## Thu Jan 2 23:10:44 2025 ## emapper-2.1.12 ## /data/home/zhuyingjie/miniforge3/envs/eggnog/bin/emapper.py -i /data/home/zhuyingjie/01_Project/01_metagenome/mangrove/mmseqs_cluster/PRJNA951480/SRR24044401/SRR24044401_p_cluster_rep_seq.fasta --output PRJNA951480_SRR24044401 --data_dir /data/software/eggnog_database -m diamond --sensmode fast --output_dir /data/home/zhuyingjie/01_Project/01_metagenome/mangrove/annotation --temp_dir /data/software/eggnog_database/temp --excel --dbmem --cpu 24 ## #query seed_ortholog evalue score eggNOG_OGs max_annot_lvl COG_category Description Preferred_name GOs EC KEGG_ko KEGG_Pathway KEGG_Module KEGG_Reaction KEGG_rclass BRITE KEGG_TC CAZy BiGG_Reaction PFAMs k59_234860_1 1165096.ARWF01000001_gene2043 3.07e-41 150.0 COG0849@1|root,COG0849@2|Bacteria,1MUSR@1224|Proteobacteria,2VGZP@28216|Betaproteobacteria,2KKH3@206350|Nitrosomonadales 206350|Nitrosomonadales D Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring ftsA - - ko:K03590 ko04112,map04112 - - - ko00000,ko00001,ko03036,ko04812 - - - FtsA,SHS2_FTSA k59_969219_1 224325.AF_1768 1.16e-55 187.0 COG0601@1|root,arCOG00751@2157|Archaea,2XTRU@28890|Euryarchaeota,246RD@183980|Archaeoglobi 183980|Archaeoglobi P ABC-type dipeptide oligopeptide nickel transport systems, permease components - - - ko:K02033 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1 k59_1590471_1 243233.MCA3046 2.44e-105 323.0 COG0021@1|root,COG0021@2|Bacteria,1MUEY@1224|Proteobacteria,1RMWP@1236|Gammaproteobacteria,1XE7N@135618|Methylococcales 135618|Methylococcales H Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate - - 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 - - - Transket_pyr,Transketolase_C,Transketolase_N k59_1421061_1 251221.35211263 2.69e-46 162.0 COG0381@1|root,COG0381@2|Bacteria,1G0BY@1117|Cyanobacteria 1117|Cyanobacteria G Belongs to the UDP-N-acetylglucosamine 2-epimerase family nfrC - 5.1.3.14 ko:K01791 ko00520,ko01100,ko05111,map00520,map01100,map05111 M00362 R00420 RC00290 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Epimerase_2 k59_1647721_1 159087.Daro_4059 2.47e-78 248.0 COG4402@1|root,COG4402@2|Bacteria,1MVMM@1224|Proteobacteria,2VZKJ@28216|Betaproteobacteria 28216|Betaproteobacteria S Uncharacterized protein conserved in bacteria (DUF2330) - - - - - - - - - - - - DUF2330 k59_1478403_1 314287.GB2207_06473 2.35e-91 281.0 COG1066@1|root,COG1066@2|Bacteria,1MUJQ@1224|Proteobacteria,1RN2E@1236|Gammaproteobacteria,1J54Q@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function radA GO:0000725,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009314,GO:0009628,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363 - ko:K04485 - - - - ko00000,ko03400 - - - AAA_25,ATPase,ChlI k59_292179_1 96561.Dole_0752 4.71e-187 527.0 COG2021@1|root,COG2021@2|Bacteria,1MVJV@1224|Proteobacteria,42N1M@68525|delta/epsilon subdivisions,2WJRJ@28221|Deltaproteobacteria,2MIEA@213118|Desulfobacterales 28221|Deltaproteobacteria E Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine metXA GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004414,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008374,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009086,GO:0009092,GO:0009987,GO:0016053,GO:0016407,GO:0016413,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.3.1.31 ko:K00641 ko00270,ko01100,ko01130,map00270,map01100,map01130 - R01776 RC00004,RC00041 ko00000,ko00001,ko01000 - - - Abhydrolase_1,Homoserine_dh,NAD_binding_3 k59_1478405_1 1121904.ARBP01000008_gene3284 2.74e-42 149.0 COG0540@1|root,COG0540@2|Bacteria,4NFIU@976|Bacteroidetes 976|Bacteroidetes F Belongs to the ATCase OTCase family - - - - - - - - - - - - OTCace,OTCace_N k59_1478405_2 1429851.X548_11660 2.34e-15 76.6 COG0367@1|root,COG0367@2|Bacteria,1MW4E@1224|Proteobacteria,1RQ7D@1236|Gammaproteobacteria,1X50J@135614|Xanthomonadales 135614|Xanthomonadales E Asparagine synthase asnB2 - 6.3.5.4 ko:K01953 ko00250,ko01100,ko01110,map00250,map01100,map01110 - R00578 RC00010 ko00000,ko00001,ko01000,ko01002 - - - Asn_synthase,GATase_7 k59_122497_1 1122137.AQXF01000007_gene3507 3.48e-69 214.0 COG5590@1|root,COG5590@2|Bacteria,1MW25@1224|Proteobacteria,2U9ST@28211|Alphaproteobacteria 28211|Alphaproteobacteria S rpsU-divergently transcribed protein cOQ9 - - ko:K18587 - - - - ko00000 - - - COQ9 k59_122497_2 1121033.AUCF01000008_gene5627 1.28e-05 47.8 COG4974@1|root,COG4974@2|Bacteria,1QU6A@1224|Proteobacteria,2TS7W@28211|Alphaproteobacteria,2JQFI@204441|Rhodospirillales 204441|Rhodospirillales D Belongs to the 'phage' integrase family. XerC subfamily xerC - - ko:K03733 - - - - ko00000,ko03036 - - - Phage_int_SAM_1,Phage_integrase k59_630378_1 396588.Tgr7_0799 4.69e-91 281.0 COG1115@1|root,COG1115@2|Bacteria,1MUI3@1224|Proteobacteria,1RMNF@1236|Gammaproteobacteria,1WXAG@135613|Chromatiales 135613|Chromatiales E PFAM sodium alanine symporter - - - ko:K03310 - - - - ko00000 2.A.25 - - Na_Ala_symp k59_404477_1 525368.HMPREF0591_2353 2.52e-100 306.0 COG0405@1|root,COG0405@2|Bacteria,2GJYW@201174|Actinobacteria,2354G@1762|Mycobacteriaceae 201174|Actinobacteria E gamma-glutamyltransferase ggtA - 2.3.2.2,3.4.19.13 ko:K00681 ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100 - R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935 RC00064,RC00090,RC00096 ko00000,ko00001,ko01000,ko01002 - - - G_glu_transpept k59_1421083_2 159087.Daro_2111 1.28e-09 62.0 COG0475@1|root,COG0475@2|Bacteria,1R9PF@1224|Proteobacteria,2VKV2@28216|Betaproteobacteria 28216|Betaproteobacteria P Sodium hydrogen exchanger - - - - - - - - - - - - Na_H_Exchanger k59_743650_1 1122137.AQXF01000001_gene3050 7.75e-81 253.0 COG4191@1|root,COG4191@2|Bacteria,1MWR3@1224|Proteobacteria,2TSS0@28211|Alphaproteobacteria 28211|Alphaproteobacteria T Histidine kinase regB - 2.7.13.3 ko:K15011 ko02020,map02020 M00523 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA k59_856942_1 1415778.JQMM01000001_gene401 1.09e-116 338.0 COG0081@1|root,COG0081@2|Bacteria,1MUE6@1224|Proteobacteria,1RMDW@1236|Gammaproteobacteria,1J4Y5@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release rplA GO:0000027,GO:0000470,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006417,GO:0006446,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015934,GO:0016043,GO:0016070,GO:0016072,GO:0017148,GO:0019222,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0034470,GO:0034622,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0045947,GO:0046483,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065003,GO:0065007,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0080090,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904,GO:2000112,GO:2000113 - ko:K02863 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L1 k59_348507_1 479437.Elen_2971 1.35e-14 83.2 COG0318@1|root,COG4948@1|root,COG0318@2|Bacteria,COG4948@2|Bacteria,2GN9C@201174|Actinobacteria,4CUU1@84998|Coriobacteriia 84998|Coriobacteriia H Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB) menC - 4.2.1.113,6.2.1.26 ko:K01911,ko:K02549 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116 R04030,R04031 RC00004,RC00014,RC01053 ko00000,ko00001,ko00002,ko01000 - - - AMP-binding,AMP-binding_C,MR_MLE_C,MR_MLE_N k59_800625_1 56110.Oscil6304_3510 2.17e-14 75.1 COG0642@1|root,COG0745@1|root,COG2202@1|root,COG2203@1|root,COG3300@1|root,COG0745@2|Bacteria,COG2202@2|Bacteria,COG2203@2|Bacteria,COG2205@2|Bacteria,COG3300@2|Bacteria,1G09B@1117|Cyanobacteria,1H71C@1150|Oscillatoriales 1117|Cyanobacteria T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - 2.7.13.3 ko:K11527 - - - - ko00000,ko01000,ko01001,ko02022 - - - GAF,HATPase_c,HisKA,MHYT,PAS,PAS_3,PAS_4,PAS_9,Response_reg k59_1138809_1 1167006.UWK_02209 3.18e-88 273.0 COG3005@1|root,COG3005@2|Bacteria,1R956@1224|Proteobacteria,42Q0X@68525|delta/epsilon subdivisions,2WMHI@28221|Deltaproteobacteria 28221|Deltaproteobacteria C NapC/NirT cytochrome c family, N-terminal region - GO:0003674,GO:0003824,GO:0005575,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0022900,GO:0031224,GO:0044237,GO:0044425,GO:0045333,GO:0055114 - - - - - - - - - - Cytochrom_NNT k59_1478435_1 1349767.GJA_765 6.26e-87 269.0 COG0001@1|root,COG0001@2|Bacteria,1MUY5@1224|Proteobacteria,2VHK9@28216|Betaproteobacteria,4730U@75682|Oxalobacteraceae 28216|Betaproteobacteria H intramolecular transferase activity, transferring amino groups hemL - 5.4.3.8 ko:K01845 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R02272 RC00677 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 k59_178471_1 481805.EcolC_2086 2.68e-34 117.0 2E08X@1|root,32VWI@2|Bacteria,1N41W@1224|Proteobacteria,1SBBU@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - ynfN - - - - - - - - - - - - k59_743667_2 530564.Psta_3322 2.63e-32 127.0 COG0526@1|root,COG3170@1|root,COG3391@1|root,COG0526@2|Bacteria,COG3170@2|Bacteria,COG3391@2|Bacteria,2IXWV@203682|Planctomycetes 203682|Planctomycetes CO PFAM NHL repeat - - - - - - - - - - - - NHL,Thioredoxin_8 k59_1647752_1 1144305.PMI02_00225 3.73e-32 126.0 COG1301@1|root,COG1301@2|Bacteria,1MU0Q@1224|Proteobacteria,2U25U@28211|Alphaproteobacteria,2K32F@204457|Sphingomonadales 204457|Sphingomonadales U Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family - - - - - - - - - - - - SDF k59_1365198_1 330214.NIDE2587 2.46e-96 305.0 COG1643@1|root,COG1643@2|Bacteria 2|Bacteria L helicase activity hrpB - 3.6.4.13 ko:K03579 - - - - ko00000,ko01000 - - - DEAD,HA2,Helicase_C,HrpB_C k59_856974_1 1158165.KB898879_gene2750 1.54e-36 143.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,1RMH0@1236|Gammaproteobacteria,1WWT2@135613|Chromatiales 135613|Chromatiales NT chemotaxis - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - HAMP,MCPsignal,dCache_3 k59_178486_1 316407.85675606 6.84e-150 430.0 COG4948@1|root,COG4948@2|Bacteria,1NAKW@1224|Proteobacteria,1RNE2@1236|Gammaproteobacteria,3XPFN@561|Escherichia 1236|Gammaproteobacteria M Catalyzes the dehydration of glucarate to 5-keto-4- deoxy-D-glucarate (5-kdGluc). Also acts on L-idarate gudD GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005975,GO:0006082,GO:0008150,GO:0008152,GO:0008872,GO:0009056,GO:0009987,GO:0016052,GO:0016054,GO:0016829,GO:0016835,GO:0016836,GO:0017144,GO:0019392,GO:0019394,GO:0019577,GO:0019579,GO:0019752,GO:0042737,GO:0042836,GO:0042838,GO:0043167,GO:0043169,GO:0043436,GO:0043648,GO:0043649,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0046872,GO:0071704,GO:1901575 4.2.1.40 ko:K01706 ko00053,ko01100,map00053,map01100 - R02752,R08056 RC00543 ko00000,ko00001,ko01000 - - iECO26_1355.ECO26_3857 MR_MLE_C,MR_MLE_N k59_913127_1 1248760.ANFZ01000004_gene2010 1.13e-17 79.0 COG2050@1|root,COG2050@2|Bacteria,1RBET@1224|Proteobacteria,2U5TM@28211|Alphaproteobacteria,2K5UC@204457|Sphingomonadales 204457|Sphingomonadales Q Thioesterase superfamily - - - - - - - - - - - - 4HBT k59_913127_2 402881.Plav_1028 4.38e-21 90.9 COG1024@1|root,COG1024@2|Bacteria,1PK10@1224|Proteobacteria,2TS4M@28211|Alphaproteobacteria 28211|Alphaproteobacteria I Belongs to the enoyl-CoA hydratase isomerase family - - - - - - - - - - - - ECH_1 k59_1703749_1 1144307.PMI04_03262 6.21e-73 229.0 COG3000@1|root,COG3000@2|Bacteria,1NXAF@1224|Proteobacteria,2U9R8@28211|Alphaproteobacteria 28211|Alphaproteobacteria I Fatty acid hydroxylase superfamily - - - - - - - - - - - - FA_hydroxylase k59_122536_1 204773.HEAR1006 5.37e-67 227.0 COG2352@1|root,COG2352@2|Bacteria,1MUD5@1224|Proteobacteria,2VI9F@28216|Betaproteobacteria,472ZX@75682|Oxalobacteraceae 28216|Betaproteobacteria H Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle ppc - 4.1.1.31 ko:K01595 ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200 M00168,M00170,M00171,M00172,M00173,M00346,M00374 R00345 RC02741 ko00000,ko00001,ko00002,ko01000 - - - PEPcase k59_1647755_1 911045.PSE_3370 4.87e-181 548.0 COG0697@1|root,COG3391@1|root,COG0697@2|Bacteria,COG3391@2|Bacteria,1QYKD@1224|Proteobacteria 1224|Proteobacteria C Cytochrome c554 and c-prime - - - - - - - - - - - - Cytochrome_C554 k59_1421133_1 1221522.B723_30995 1.35e-73 234.0 COG3547@1|root,COG3547@2|Bacteria,1PHVS@1224|Proteobacteria,1SY2B@1236|Gammaproteobacteria,1YU04@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria L Transposase (IS116 IS110 IS902 family) - - - - - - - - - - - - DEDD_Tnp_IS110 k59_1590555_1 443152.MDG893_12745 5.89e-68 216.0 COG0313@1|root,COG0313@2|Bacteria,1MU0E@1224|Proteobacteria,1RM7U@1236|Gammaproteobacteria,463Z3@72275|Alteromonadaceae 1236|Gammaproteobacteria H Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA rsmI GO:0000154,GO:0000451,GO:0000453,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070677,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.198 ko:K07056 - - - - ko00000,ko01000,ko03009 - - - TP_methylase k59_857000_1 1229276.DI53_0080 2.16e-48 165.0 COG0053@1|root,COG0053@2|Bacteria,4NEID@976|Bacteroidetes,1IQPK@117747|Sphingobacteriia 976|Bacteroidetes P Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family fieF - - - - - - - - - - - Cation_efflux,ZT_dimer k59_1082587_1 1122137.AQXF01000002_gene479 1.69e-103 310.0 COG1960@1|root,COG1960@2|Bacteria,1MVJC@1224|Proteobacteria,2TUVB@28211|Alphaproteobacteria 28211|Alphaproteobacteria I acyl-CoA dehydrogenase MA20_22780 - 1.3.8.7 ko:K00249 ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320 M00013,M00036,M00087 R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754 RC00052,RC00068,RC00076,RC00095,RC00148,RC00246 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_1082587_2 1122137.AQXF01000002_gene480 3.86e-143 421.0 COG0534@1|root,COG0534@2|Bacteria,1MVRV@1224|Proteobacteria,2U34G@28211|Alphaproteobacteria 28211|Alphaproteobacteria V Mate efflux family protein - - - - - - - - - - - - MatE k59_1308696_1 876044.IMCC3088_1272 1.11e-79 253.0 COG4146@1|root,COG4146@2|Bacteria,1MXWV@1224|Proteobacteria,1RR4S@1236|Gammaproteobacteria 1236|Gammaproteobacteria E Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family sglT - - ko:K03307 - - - - ko00000 2.A.21 - - SSF k59_404554_1 74547.PMT_1951 2.63e-13 72.8 COG0806@1|root,COG0806@2|Bacteria,1G5WP@1117|Cyanobacteria,1MPKE@1212|Prochloraceae 1117|Cyanobacteria J An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes rimM - - ko:K02860 - - - - ko00000,ko03009 - - - PRC,RimM k59_1760406_1 107636.JQNK01000009_gene3602 1.01e-14 80.9 COG2304@1|root,COG2931@1|root,COG2304@2|Bacteria,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,2TRVY@28211|Alphaproteobacteria,36ZVS@31993|Methylocystaceae 28211|Alphaproteobacteria Q Haemolysin-type calcium-binding repeat (2 copies) - - - - - - - - - - - - FG-GAP,HemolysinCabind,Integrin_beta k59_857011_1 247639.MGP2080_06007 1.22e-100 306.0 COG4146@1|root,COG4146@2|Bacteria,1MXWV@1224|Proteobacteria,1RR4S@1236|Gammaproteobacteria 1236|Gammaproteobacteria E Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family sglT - - ko:K03307 - - - - ko00000 2.A.21 - - SSF k59_1365232_1 317025.Tcr_1066 7.83e-06 47.0 COG0531@1|root,COG0531@2|Bacteria,1QXK2@1224|Proteobacteria,1S18B@1236|Gammaproteobacteria 1236|Gammaproteobacteria E amino acid - - - ko:K07076 - - - - ko00000 - - - AA_permease_2 k59_1365232_2 1128421.JAGA01000001_gene2249 3.14e-50 177.0 COG3158@1|root,COG3158@2|Bacteria,2NQH9@2323|unclassified Bacteria 2|Bacteria P K+ potassium transporter kup - - ko:K03549 - - - - ko00000,ko02000 2.A.72 - - K_trans k59_348571_1 637905.SVI_3142 1.07e-179 520.0 COG1574@1|root,COG1574@2|Bacteria,1MWP2@1224|Proteobacteria,1RNB7@1236|Gammaproteobacteria,2Q9PB@267890|Shewanellaceae 1236|Gammaproteobacteria S PFAM Amidohydrolase 3 - - - - - - - - - - - - Amidohydro_3 k59_1590577_1 349521.HCH_04238 3.08e-32 129.0 COG4251@1|root,COG4251@2|Bacteria,1NSQ1@1224|Proteobacteria,1T3CC@1236|Gammaproteobacteria,1XMVM@135619|Oceanospirillales 135619|Oceanospirillales T Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) - - - - - - - - - - - - HATPase_c,HisKA,PAS,PAS_3,Phosphonate-bd k59_1308713_1 743720.Psefu_0421 1.32e-35 139.0 COG5009@1|root,COG5009@2|Bacteria,1MU5A@1224|Proteobacteria,1RM7J@1236|Gammaproteobacteria,1YXQ8@136845|Pseudomonas putida group 1236|Gammaproteobacteria M Penicillin-binding protein 1A mrcA GO:0000270,GO:0003674,GO:0003824,GO:0004180,GO:0004185,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006022,GO:0006023,GO:0006024,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0008238,GO:0008360,GO:0008658,GO:0008955,GO:0009002,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016021,GO:0016740,GO:0016757,GO:0016758,GO:0016787,GO:0017171,GO:0019538,GO:0022603,GO:0022604,GO:0030203,GO:0031224,GO:0031226,GO:0031406,GO:0033218,GO:0033293,GO:0034645,GO:0036094,GO:0042221,GO:0042546,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044425,GO:0044459,GO:0044464,GO:0046677,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051128,GO:0065007,GO:0065008,GO:0070008,GO:0070011,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:0097159,GO:0140096,GO:1901135,GO:1901137,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901681 2.4.1.129,3.4.16.4 ko:K05366 ko00550,ko01100,ko01501,map00550,map01100,map01501 - - - ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 - PCB_OB,Transgly,Transpeptidase k59_1138861_1 1379270.AUXF01000002_gene1817 1.26e-29 116.0 COG0668@1|root,COG0668@2|Bacteria,1ZSU5@142182|Gemmatimonadetes 142182|Gemmatimonadetes M Conserved TM helix - - - - - - - - - - - - TM_helix k59_1138861_2 1286631.X805_07450 9.76e-24 95.9 COG0517@1|root,COG0517@2|Bacteria,1N0H3@1224|Proteobacteria,2VRN8@28216|Betaproteobacteria,1KM7Q@119065|unclassified Burkholderiales 28216|Betaproteobacteria S Domain in cystathionine beta-synthase and other proteins. - - - - - - - - - - - - CBS k59_9612_2 331869.BAL199_25674 9.27e-16 79.3 COG0457@1|root,COG0457@2|Bacteria,1N01S@1224|Proteobacteria,2TSR4@28211|Alphaproteobacteria,4BPJ0@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria S COG0457 FOG TPR repeat - - - - - - - - - - - - - k59_1478507_1 316407.85676497 3.17e-168 469.0 COG5571@1|root,COG5571@2|Bacteria,1N2A9@1224|Proteobacteria,1RSZ5@1236|Gammaproteobacteria,3XM2N@561|Escherichia 1236|Gammaproteobacteria N Autotransporter beta-domain yhjY - - - - - - - - - - - Autotransporter k59_1590585_2 1232430.CAVG010000108_gene993 0.000138 51.6 COG1232@1|root,COG1232@2|Bacteria,1TQ6W@1239|Firmicutes,4HAUG@91061|Bacilli,4GXIT@90964|Staphylococcaceae 91061|Bacilli H Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX hemY - 1.3.3.15,1.3.3.4 ko:K00231 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R03222,R04178 RC00885 ko00000,ko00001,ko00002,ko01000 - - iSB619.SA_RS09325 Amino_oxidase k59_404586_1 105559.Nwat_0811 1.26e-15 76.6 COG1138@1|root,COG1138@2|Bacteria,1MUQS@1224|Proteobacteria,1RMY5@1236|Gammaproteobacteria,1WWM9@135613|Chromatiales 135613|Chromatiales O Cytochrome c-type biogenesis protein - - - ko:K02198 - - - - ko00000,ko02000 9.B.14.1 - - CcmF_C,Cytochrom_C_asm k59_404586_2 76114.ebA3522 2e-42 145.0 COG0526@1|root,COG0526@2|Bacteria,1RI3N@1224|Proteobacteria,2VR8D@28216|Betaproteobacteria,2KW3E@206389|Rhodocyclales 206389|Rhodocyclales CO Periplasmic protein thiol disulfide oxidoreductase DsbE ccmG - - ko:K02199 - - - - ko00000,ko03110 - - - Redoxin k59_913177_1 1280944.HY17_05510 6.06e-14 80.1 COG0587@1|root,COG0587@2|Bacteria,1MUE4@1224|Proteobacteria,2TRUB@28211|Alphaproteobacteria,43WC1@69657|Hyphomonadaceae 28211|Alphaproteobacteria L DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase dnaE2 - 2.7.7.7 ko:K02337,ko:K14162 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon k59_1308733_1 305700.B447_18343 3.41e-181 534.0 COG0188@1|root,COG0188@2|Bacteria,1MURI@1224|Proteobacteria,2VH7P@28216|Betaproteobacteria,2KUX1@206389|Rhodocyclales 206389|Rhodocyclales L Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule parC - - ko:K02621 - - - - ko00000,ko01000,ko02048,ko03032,ko03036 - - - DNA_gyraseA_C,DNA_topoisoIV k59_1026846_1 465817.ETA_08660 1.89e-29 121.0 COG3209@1|root,COG4104@1|root,COG3209@2|Bacteria,COG4104@2|Bacteria,1MVV1@1224|Proteobacteria,1SKYM@1236|Gammaproteobacteria,3X5EE@551|Erwinia 1236|Gammaproteobacteria M silverDB - - - - - - - - - - - - PAAR_motif,RHS,RHS_repeat,Tox-HNH-EHHH k59_575117_38 1137799.GZ78_04025 1.73e-25 101.0 COG4387@1|root,COG4387@2|Bacteria,1N1K0@1224|Proteobacteria,1S9W3@1236|Gammaproteobacteria,1XM0H@135619|Oceanospirillales 135619|Oceanospirillales S Protein of unknown function (DUF1320) - - - - - - - - - - - - DUF1320 k59_575117_40 312309.VF_2640 6.7e-07 48.5 2EICU@1|root,33C46@2|Bacteria,1NGMA@1224|Proteobacteria,1SGJZ@1236|Gammaproteobacteria,1XZI9@135623|Vibrionales 135623|Vibrionales S Protein of unknown function (DUF2635) - - - - - - - - - - - - DUF2635 k59_575117_41 42565.FP66_08445 1.88e-127 387.0 COG4386@1|root,COG4386@2|Bacteria,1MXZD@1224|Proteobacteria,1RN4Q@1236|Gammaproteobacteria,1XNBI@135619|Oceanospirillales 135619|Oceanospirillales S Phage tail sheath C-terminal domain - - - - - - - - - - - - Phage_sheath_1,Phage_sheath_1C k59_575117_43 690850.Desaf_0700 4.54e-20 87.8 COG4518@1|root,COG4518@2|Bacteria,1NJ65@1224|Proteobacteria,431N7@68525|delta/epsilon subdivisions,2WWZZ@28221|Deltaproteobacteria,2MH7M@213115|Desulfovibrionales 28221|Deltaproteobacteria S Phage tail assembly chaperone proteins, E, or 41 or 14 - - - - - - - - - - - - Phage_TAC_7 k59_575117_44 1121406.JAEX01000002_gene847 5.6e-97 318.0 COG5283@1|root,COG5283@2|Bacteria,1R5KW@1224|Proteobacteria,42ZCF@68525|delta/epsilon subdivisions,2WU9W@28221|Deltaproteobacteria,2M9Q0@213115|Desulfovibrionales 28221|Deltaproteobacteria S phage tail tape measure protein - - - - - - - - - - - - - k59_575117_45 1122135.KB893169_gene2494 4.08e-43 163.0 COG4228@1|root,COG4228@2|Bacteria,1R4HU@1224|Proteobacteria,2UD79@28211|Alphaproteobacteria 28211|Alphaproteobacteria S COG4228 Mu-like prophage DNA circulation protein - - - - - - - - - - - - DNA_circ_N k59_575117_46 1278073.MYSTI_01921 1.53e-54 189.0 COG4379@1|root,COG4379@2|Bacteria,1MX68@1224|Proteobacteria,42RQV@68525|delta/epsilon subdivisions,2WNV4@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Tail protein - - - - - - - - - - - - - k59_575117_47 94624.Bpet4425 1.47e-21 94.4 COG4384@1|root,COG4384@2|Bacteria,1MZ4H@1224|Proteobacteria,2VWYQ@28216|Betaproteobacteria 28216|Betaproteobacteria S Phage baseplate assembly protein V - - - - - - - - - - - - Phage_Mu_Gp45 k59_575117_48 266265.Bxe_A3048 8.02e-21 89.7 COG4381@1|root,COG4381@2|Bacteria,1N954@1224|Proteobacteria,2VX4R@28216|Betaproteobacteria,1K9WU@119060|Burkholderiaceae 28216|Betaproteobacteria S Phage protein GP46 - - - - - - - - - - - - GP46 k59_575117_50 715226.ABI_08490 4.56e-73 237.0 COG3299@1|root,COG3299@2|Bacteria,1PYEJ@1224|Proteobacteria,2U8GE@28211|Alphaproteobacteria 28211|Alphaproteobacteria S phage Mu protein gp47 - - - - - - - - - - - - Baseplate_J k59_575117_55 580332.Slit_0250 2.07e-114 335.0 COG0338@1|root,COG0338@2|Bacteria,1P85S@1224|Proteobacteria,2VKN7@28216|Betaproteobacteria,44W4J@713636|Nitrosomonadales 28216|Betaproteobacteria L D12 class N6 adenine-specific DNA methyltransferase dam - 2.1.1.72 ko:K06223 ko03430,map03430 - - - ko00000,ko00001,ko01000,ko02048,ko03032,ko03400 - - - MethyltransfD12 k59_575117_58 399795.CtesDRAFT_PD5228 8.79e-37 137.0 COG3000@1|root,COG3000@2|Bacteria,1PDBI@1224|Proteobacteria,2VPG6@28216|Betaproteobacteria,4AGK2@80864|Comamonadaceae 28216|Betaproteobacteria I Fatty acid hydroxylase superfamily - - - - - - - - - - - - FA_hydroxylase k59_67373_1 1122137.AQXF01000002_gene141 8.36e-103 308.0 COG0750@1|root,COG0750@2|Bacteria,1MU91@1224|Proteobacteria,2TQXJ@28211|Alphaproteobacteria 28211|Alphaproteobacteria M zinc metalloprotease rseP - - ko:K11749 ko02024,ko04112,map02024,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - PDZ,PDZ_2,Peptidase_M50 k59_575134_1 222534.KB893717_gene1939 4.98e-58 189.0 COG0047@1|root,COG0047@2|Bacteria,2GMJY@201174|Actinobacteria,4ERSR@85013|Frankiales 201174|Actinobacteria F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL purQ GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044424,GO:0044464,GO:0071944 6.3.5.3 ko:K01952 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04463 RC00010,RC01160 ko00000,ko00001,ko00002,ko01000 - - - GATase_5 k59_349844_1 436308.Nmar_1008 3.67e-114 350.0 COG0458@1|root,COG0624@1|root,arCOG01107@2157|Archaea,arCOG01596@2157|Archaea 2157|Archaea EF ATP-grasp domain cxp2 - 3.4.17.11,3.5.1.18,6.3.2.4 ko:K01295,ko:K01439,ko:K01921,ko:K16181 ko00300,ko00473,ko00550,ko01100,ko01120,ko01230,ko01502,map00300,map00473,map00550,map01100,map01120,map01230,map01502 M00016 R01150,R02734,R10011 RC00064,RC00090,RC00096,RC00141 ko00000,ko00001,ko00002,ko01000,ko01002,ko01011 - - - ATP-grasp_3,CPSase_L_D2,Dala_Dala_lig_C,M20_dimer,Peptidase_M20 k59_1761680_1 555088.DealDRAFT_2304 8.06e-46 166.0 COG1022@1|root,COG1022@2|Bacteria,1V0YG@1239|Firmicutes,25E9H@186801|Clostridia 186801|Clostridia I AMP-binding enzyme - - 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding,AMP-binding_C k59_127682_1 765912.Thimo_0463 5.77e-15 76.6 COG3028@1|root,COG3028@2|Bacteria,1MZ4R@1224|Proteobacteria,1S9JJ@1236|Gammaproteobacteria,1WY21@135613|Chromatiales 135613|Chromatiales S Belongs to the UPF0307 family - - - ko:K09889 - - - - ko00000,ko03009 - - - DUF615 k59_127682_2 450851.PHZ_c0074 4.16e-68 231.0 COG2211@1|root,COG2211@2|Bacteria,1MVUM@1224|Proteobacteria,2TVI8@28211|Alphaproteobacteria,2KJSU@204458|Caulobacterales 204458|Caulobacterales G MFS/sugar transport protein - - - - - - - - - - - - MFS_2 k59_1143909_1 436308.Nmar_1064 8.64e-30 113.0 COG0444@1|root,arCOG00181@2157|Archaea,41S9V@651137|Thaumarchaeota 651137|Thaumarchaeota E Oligopeptide/dipeptide transporter, C-terminal region - - - ko:K02031 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - ABC_tran,oligo_HPY k59_1143909_2 436308.Nmar_1060 1.6e-24 95.5 arCOG10572@1|root,arCOG10572@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_1484025_1 991905.SL003B_2232 6.32e-84 261.0 COG0148@1|root,COG0148@2|Bacteria,1MU1N@1224|Proteobacteria,2TR04@28211|Alphaproteobacteria,4BPPV@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria G Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis eno - 4.2.1.11 ko:K01689 ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066 M00001,M00002,M00003,M00346,M00394 R00658 RC00349 ko00000,ko00001,ko00002,ko01000,ko03019,ko04147 - - - Enolase_C,Enolase_N k59_1708871_1 1122137.AQXF01000009_gene12 0.0 913.0 COG0086@1|root,COG0086@2|Bacteria,1MU3M@1224|Proteobacteria,2TRHV@28211|Alphaproteobacteria 28211|Alphaproteobacteria K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoC GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234 2.7.7.6 ko:K03046,ko:K13797 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5 k59_127686_1 199310.c4176 2.5e-59 197.0 COG1866@1|root,COG1866@2|Bacteria,1MWXN@1224|Proteobacteria,1RPM0@1236|Gammaproteobacteria,3XMXQ@561|Escherichia 1236|Gammaproteobacteria F Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA pckA GO:0000287,GO:0003674,GO:0003824,GO:0004611,GO:0004612,GO:0005488,GO:0005509,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006094,GO:0008150,GO:0008152,GO:0009058,GO:0016051,GO:0016829,GO:0016830,GO:0016831,GO:0019318,GO:0019319,GO:0043167,GO:0043169,GO:0044238,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046364,GO:0046872,GO:0071704,GO:1901576 4.1.1.49 ko:K01610 ko00010,ko00020,ko00620,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00710,map01100,map01110,map01120,map01130,map01200 M00003,M00170 R00341 RC00002,RC02741 ko00000,ko00001,ko00002,ko01000 - - iSF_1195.SF3422,iUTI89_1310.UTI89_C3903 PEPCK_ATP k59_1257031_1 1123054.KB907752_gene2589 8.39e-62 213.0 COG0596@1|root,COG0596@2|Bacteria,1R6KU@1224|Proteobacteria,1RNTQ@1236|Gammaproteobacteria 1236|Gammaproteobacteria I Alpha beta hydrolase - - - - - - - - - - - - Abhydrolase_1,Abhydrolase_4 k59_748373_1 13690.CP98_01848 8.57e-55 185.0 COG2015@1|root,COG2015@2|Bacteria,1MU82@1224|Proteobacteria,2U7UU@28211|Alphaproteobacteria,2K9ER@204457|Sphingomonadales 204457|Sphingomonadales Q Alkyl sulfatase dimerisation - - - - - - - - - - - - Alkyl_sulf_dimr,Lactamase_B k59_748376_1 1121930.AQXG01000001_gene1203 1.25e-67 230.0 COG0841@1|root,COG0841@2|Bacteria,4NGCI@976|Bacteroidetes 976|Bacteroidetes V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K03296 - - - - ko00000 2.A.6.2 - - ACR_tran k59_1765520_1 1123035.ARLA01000028_gene2540 2.05e-68 211.0 2DUTC@1|root,33S5P@2|Bacteria,4P1XC@976|Bacteroidetes,1I7K2@117743|Flavobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_353883_1 1144305.PMI02_02189 1.08e-71 219.0 COG0315@1|root,COG0315@2|Bacteria,1RCYZ@1224|Proteobacteria,2U747@28211|Alphaproteobacteria,2K4GG@204457|Sphingomonadales 204457|Sphingomonadales H Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP) moaC - 4.6.1.17 ko:K03637 ko00790,ko01100,ko04122,map00790,map01100,map04122 - R11372 RC03425 ko00000,ko00001,ko01000 - - - MoaC k59_353890_1 1458275.AZ34_15605 2.12e-79 245.0 COG5424@1|root,COG5424@2|Bacteria,1QVK0@1224|Proteobacteria,2VMEZ@28216|Betaproteobacteria 28216|Betaproteobacteria H Iron-containing redox enzyme - - - - - - - - - - - - Haem_oxygenas_2 k59_918168_1 362418.IW19_22365 1.67e-64 218.0 COG3119@1|root,COG3119@2|Bacteria,4NEBN@976|Bacteroidetes,1HZSK@117743|Flavobacteriia,2NUQB@237|Flavobacterium 976|Bacteroidetes P Sulfatase - - 3.1.6.1 ko:K01130 ko00140,ko00600,map00140,map00600 - R03980,R04856 RC00128,RC00231 ko00000,ko00001,ko01000 - - - Sulfatase k59_862751_1 270374.MELB17_01860 4.74e-68 223.0 COG0642@1|root,COG2770@1|root,COG2205@2|Bacteria,COG2770@2|Bacteria,1MW8M@1224|Proteobacteria,1RQPH@1236|Gammaproteobacteria,467PM@72275|Alteromonadaceae 1236|Gammaproteobacteria T Signal transduction histidine kinase - - - - - - - - - - - - HAMP,HATPase_c,HisKA k59_1426380_1 1120956.JHZK01000034_gene2050 3.67e-133 404.0 COG0129@1|root,COG0363@1|root,COG0129@2|Bacteria,COG0363@2|Bacteria,1MUTQ@1224|Proteobacteria,2TRTQ@28211|Alphaproteobacteria,1JNQ4@119043|Rhodobiaceae 28211|Alphaproteobacteria E Dehydratase family - - 4.2.1.82 ko:K22186 ko00040,map00040 - R02429 RC00543 ko00000,ko00001,ko01000 - - - ILVD_EDD k59_127698_1 1207063.P24_13378 0.000859 41.2 COG1574@1|root,COG1574@2|Bacteria,1MWP2@1224|Proteobacteria,2TXAW@28211|Alphaproteobacteria,2JRIA@204441|Rhodospirillales 204441|Rhodospirillales S Amidohydrolase family - - - - - - - - - - - - Amidohydro_3 k59_127698_2 1207063.P24_13383 1.13e-53 178.0 COG0523@1|root,COG0523@2|Bacteria,1MVZV@1224|Proteobacteria,2VGB7@28211|Alphaproteobacteria,2JYRY@204441|Rhodospirillales 204441|Rhodospirillales S Cobalamin synthesis protein cobW C-terminal domain - - - - - - - - - - - - CobW_C,cobW k59_1540020_1 1123236.KB899388_gene2107 6.42e-66 210.0 COG3264@1|root,COG3264@2|Bacteria,1MWSA@1224|Proteobacteria,1RMYY@1236|Gammaproteobacteria,465WZ@72275|Alteromonadaceae 1236|Gammaproteobacteria M Mechanosensitive ion channel - - - - - - - - - - - - MS_channel k59_1257044_1 436308.Nmar_0553 1.4e-169 476.0 COG1830@1|root,arCOG04044@2157|Archaea,41SCP@651137|Thaumarchaeota 651137|Thaumarchaeota E Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2- amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids aroA' - 2.2.1.10,4.1.2.13 ko:K16306 ko00010,ko00030,ko00051,ko00400,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00400,map00680,map01100,map01110,map01120,map01130,map01200,map01230 M00001 R01068,R01070,R02568,R08568 RC00438,RC00439,RC00721,RC02301 ko00000,ko00001,ko00002,ko01000 - - - DeoC k59_1257044_2 436308.Nmar_0552 1.49e-19 86.7 COG1465@1|root,arCOG04353@2157|Archaea,41S88@651137|Thaumarchaeota 651137|Thaumarchaeota E Catalyzes the oxidative deamination and cyclization of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3- dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis aroB' - 1.4.1.24 ko:K11646 ko00400,ko01110,ko01130,map00400,map01110,map01130 - R08569 RC02302 ko00000,ko00001,ko01000 - - - DHQS k59_1652987_1 1484460.JSWG01000007_gene3087 3.91e-133 401.0 COG4485@1|root,COG4485@2|Bacteria,4NEE5@976|Bacteroidetes,1HX3C@117743|Flavobacteriia 976|Bacteroidetes S PFAM Bacterial membrane protein YfhO - - - - - - - - - - - - YfhO k59_1143959_1 1144275.COCOR_05212 7.07e-10 62.4 COG3210@1|root,COG3210@2|Bacteria,1P4K4@1224|Proteobacteria 1224|Proteobacteria U domain, Protein - - - - - - - - - - - - - k59_297399_1 1131266.ARWQ01000004_gene1449 3.64e-10 60.5 COG0715@1|root,arCOG01803@2157|Archaea,41SG5@651137|Thaumarchaeota 651137|Thaumarchaeota P TIGRFAM ABC transporter, substrate-binding protein, aliphatic sulfonates family - - - ko:K02051 - M00188 - - ko00000,ko00002,ko02000 3.A.1.16,3.A.1.17 - - NMT1_2 k59_297399_2 436308.Nmar_1284 1.22e-91 273.0 COG1116@1|root,arCOG00193@2157|Archaea,41S6Q@651137|Thaumarchaeota 651137|Thaumarchaeota E ABC-type nitrate sulfonate bicarbonate transport system, ATPase component - - - ko:K02049 - M00188 - - ko00000,ko00002,ko02000 3.A.1.16,3.A.1.17 - - ABC_tran k59_1652989_1 1168065.DOK_07919 9.16e-104 317.0 COG0493@1|root,COG1143@1|root,COG0493@2|Bacteria,COG1143@2|Bacteria,1MU2H@1224|Proteobacteria,1RREP@1236|Gammaproteobacteria,1J5XD@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster - - - - - - - - - - - - Fer4_20,Fer4_7,NADH_4Fe-4S,Pyr_redox_2 k59_184087_2 1056820.KB900640_gene241 2.59e-05 45.4 COG3829@1|root,COG3829@2|Bacteria,1QZHD@1224|Proteobacteria,1S631@1236|Gammaproteobacteria,2PPCD@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria KT transcription factor binding - - - - - - - - - - - - - k59_579197_1 666685.R2APBS1_0511 1.28e-23 99.8 COG0642@1|root,COG0642@2|Bacteria,1MX6R@1224|Proteobacteria,1T213@1236|Gammaproteobacteria,1X4YX@135614|Xanthomonadales 135614|Xanthomonadales T Signal transduction histidine kinase - - 2.7.13.3 ko:K07637 ko01503,ko02020,map01503,map02020 M00444,M00709,M00721,M00723,M00724,M00744 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko01504,ko02022 - - - HATPase_c k59_579197_2 1122218.KB893654_gene2395 1.82e-16 76.3 COG1694@1|root,COG3956@2|Bacteria,1MVKM@1224|Proteobacteria,2TRC9@28211|Alphaproteobacteria,1JTN3@119045|Methylobacteriaceae 28211|Alphaproteobacteria S PFAM MazG nucleotide pyrophosphohydrolase mazG GO:0003674,GO:0003824,GO:0006139,GO:0006163,GO:0006195,GO:0006203,GO:0006213,GO:0006220,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0007154,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009143,GO:0009144,GO:0009146,GO:0009147,GO:0009149,GO:0009151,GO:0009155,GO:0009164,GO:0009166,GO:0009199,GO:0009200,GO:0009203,GO:0009204,GO:0009208,GO:0009210,GO:0009211,GO:0009213,GO:0009215,GO:0009217,GO:0009218,GO:0009219,GO:0009222,GO:0009223,GO:0009259,GO:0009261,GO:0009262,GO:0009264,GO:0009267,GO:0009394,GO:0009605,GO:0009987,GO:0009991,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0019693,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0042454,GO:0042594,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0046046,GO:0046047,GO:0046051,GO:0046052,GO:0046060,GO:0046061,GO:0046070,GO:0046075,GO:0046076,GO:0046080,GO:0046081,GO:0046131,GO:0046133,GO:0046135,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0050896,GO:0051716,GO:0055086,GO:0071496,GO:0071704,GO:0072521,GO:0072523,GO:0072527,GO:0072529,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1901657,GO:1901658 3.6.1.9 ko:K02499,ko:K04765 ko00230,ko00240,ko00760,ko00770,ko01100,map00230,map00240,map00760,map00770,map01100 - R00086,R00087,R00103,R00287,R00426,R00515,R00662,R00720,R03004,R03036,R11323 RC00002 ko00000,ko00001,ko01000,ko03036 - - - MazG k59_184089_1 1484460.JSWG01000009_gene592 3.01e-93 285.0 COG1257@1|root,COG1257@2|Bacteria,4NGNG@976|Bacteroidetes,1HY0M@117743|Flavobacteriia 976|Bacteroidetes I Belongs to the HMG-CoA reductase family mvaA - 1.1.1.88 ko:K00054 ko00900,ko01110,ko01130,map00900,map01110,map01130 - R02081 RC00004,RC00644 ko00000,ko00001,ko01000 - - - HMG-CoA_red k59_184089_2 1380600.AUYN01000006_gene306 4.96e-17 80.5 COG1577@1|root,COG2827@1|root,COG1577@2|Bacteria,COG2827@2|Bacteria,4NEXC@976|Bacteroidetes,1HY6C@117743|Flavobacteriia 976|Bacteroidetes I GHMP Kinase - - - - - - - - - - - - - k59_1031988_1 1121887.AUDK01000001_gene670 2.98e-66 213.0 COG1609@1|root,COG1609@2|Bacteria,4NDW6@976|Bacteroidetes,1HY65@117743|Flavobacteriia,2NYT0@237|Flavobacterium 976|Bacteroidetes K Periplasmic binding proteins and sugar binding domain of LacI family - - - ko:K02529,ko:K05499 - - - - ko00000,ko03000 - - - LacI,Peripla_BP_1,Peripla_BP_3 k59_1031988_2 1121930.AQXG01000002_gene2248 5.72e-08 56.6 COG1629@1|root,COG1629@2|Bacteria,4PKAS@976|Bacteroidetes 976|Bacteroidetes P TonB-linked outer membrane protein, SusC RagA family - - - - - - - - - - - - CarbopepD_reg_2,Plug,TonB_dep_Rec k59_522165_2 1279017.AQYJ01000026_gene57 3.25e-15 74.3 COG1360@1|root,COG2885@1|root,COG1360@2|Bacteria,COG2885@2|Bacteria,1QW22@1224|Proteobacteria,1T4AK@1236|Gammaproteobacteria,46ACU@72275|Alteromonadaceae 1236|Gammaproteobacteria M OmpA family - - - - - - - - - - - - DUF11,OmpA k59_409742_1 1112216.JH594425_gene1207 4.82e-81 252.0 COG1228@1|root,COG1228@2|Bacteria,1MVAF@1224|Proteobacteria,2TTYC@28211|Alphaproteobacteria,2K0Q2@204457|Sphingomonadales 204457|Sphingomonadales Q COG1228 Imidazolonepropionase and related amidohydrolases - - - - - - - - - - - - Amidohydro_1 k59_1426419_1 243233.MCA1802 8.89e-40 143.0 COG1670@1|root,COG1670@2|Bacteria,1RB1I@1224|Proteobacteria,1S7ZE@1236|Gammaproteobacteria,1XGDV@135618|Methylococcales 135618|Methylococcales J Domain of unknown function (DUF4202) - - - - - - - - - - - - DUF4202 k59_1426419_2 196367.JNFG01000011_gene6012 3e-70 225.0 COG1024@1|root,COG1024@2|Bacteria,1MWZC@1224|Proteobacteria,2VJVA@28216|Betaproteobacteria,1K3KP@119060|Burkholderiaceae 28216|Betaproteobacteria I Enoyl-CoA hydratase/isomerase - - 4.2.1.17 ko:K01715 ko00650,ko01200,map00650,map01200 - R03026 RC00831 ko00000,ko00001,ko01000 - - - ECH_1 k59_1765571_1 1121015.N789_07180 1.74e-48 162.0 COG1952@1|root,COG1952@2|Bacteria,1RI75@1224|Proteobacteria,1S62H@1236|Gammaproteobacteria,1X65X@135614|Xanthomonadales 135614|Xanthomonadales U One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA secB - - ko:K03071 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044,ko03110 3.A.5 - - SecB k59_71610_2 1123393.KB891317_gene2209 5.82e-29 105.0 COG0662@1|root,COG0662@2|Bacteria,1QW6S@1224|Proteobacteria 1224|Proteobacteria G Cupin domain - - - - - - - - - - - - Cupin_2 k59_1426427_1 1121877.JQKF01000001_gene1393 7.05e-44 160.0 COG3552@1|root,COG3552@2|Bacteria,2GNTS@201174|Actinobacteria,4CMU1@84992|Acidimicrobiia 84992|Acidimicrobiia S VWA domain containing CoxE-like protein - - - ko:K07161 - - - - ko00000 - - - VWA_CoxE k59_635682_1 1122137.AQXF01000002_gene54 4.07e-197 554.0 COG0215@1|root,COG0215@2|Bacteria,1MV8H@1224|Proteobacteria,2TQQ1@28211|Alphaproteobacteria 28211|Alphaproteobacteria J Belongs to the class-I aminoacyl-tRNA synthetase family cysS GO:0000166,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.1.1.16 ko:K01883 ko00970,map00970 M00359,M00360 R03650 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DALR_2,tRNA-synt_1e k59_71628_1 296591.Bpro_3193 2.29e-50 184.0 COG2909@1|root,COG2909@2|Bacteria,1PXC4@1224|Proteobacteria,2W18D@28216|Betaproteobacteria 28216|Betaproteobacteria K AAA ATPase domain - - - - - - - - - - - - AAA_16,GerE k59_1257081_1 34007.IT40_18570 1.03e-20 94.4 COG4638@1|root,COG4638@2|Bacteria,1MWXW@1224|Proteobacteria,2TSJ5@28211|Alphaproteobacteria 28211|Alphaproteobacteria P COG4638 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit - - - ko:K00479 - - - - ko00000 - - - Rieske,Ring_hydroxyl_A k59_409782_1 436308.Nmar_1771 1.29e-134 393.0 COG0174@1|root,arCOG01909@2157|Archaea,41SD6@651137|Thaumarchaeota 651137|Thaumarchaeota E TIGRFAM glutamine synthetase, type I - - 6.3.1.2 ko:K01915 ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 - R00253 RC00010,RC02798 ko00000,ko00001,ko01000,ko04147 - - - Gln-synt_C,Gln-synt_N k59_919165_1 595460.RRSWK_01802 6.92e-37 134.0 COG0040@1|root,COG0040@2|Bacteria,2IXEV@203682|Planctomycetes 203682|Planctomycetes F ATP phosphoribosyltransferase hisG GO:0000105,GO:0003674,GO:0003824,GO:0003879,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.17 ko:K00765 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R01071 RC02819,RC03200 ko00000,ko00001,ko00002,ko01000 - - - HisG,HisG_C k59_919165_2 999611.KI421504_gene2142 6.92e-12 64.3 COG0140@1|root,COG0140@2|Bacteria,1MZEE@1224|Proteobacteria,2UBU3@28211|Alphaproteobacteria,281RM@191028|Leisingera 28211|Alphaproteobacteria E Phosphoribosyl-ATP pyrophosphohydrolase hisE - 3.6.1.31 ko:K01523 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04035 RC00002 ko00000,ko00001,ko00002,ko01000 - - - PRA-PH k59_1371779_1 246200.SPO0751 3.22e-71 224.0 COG2114@1|root,COG2114@2|Bacteria,1MWHK@1224|Proteobacteria,2TR2J@28211|Alphaproteobacteria,4NDPJ@97050|Ruegeria 28211|Alphaproteobacteria T Adenylyl- / guanylyl cyclase, catalytic domain - - 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 - - - Guanylate_cyc k59_185253_1 158500.BV97_00533 6.11e-91 277.0 COG0457@1|root,COG0457@2|Bacteria,1NU2Z@1224|Proteobacteria,2UP5I@28211|Alphaproteobacteria,2K8VY@204457|Sphingomonadales 204457|Sphingomonadales S Sulfotransferase domain - - - - - - - - - - - - Sulfotransfer_3 k59_1597191_1 1229909.NSED_09725 8.99e-45 146.0 arCOG08691@1|root,arCOG08691@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_1597191_2 1229909.NSED_09730 2.69e-41 135.0 arCOG08662@1|root,arCOG08662@2157|Archaea 1229909.NSED_09730|- - - - - - - - - - - - - - - - k59_749571_1 1122599.AUGR01000004_gene2175 9.35e-115 341.0 COG0399@1|root,COG0399@2|Bacteria,1MUPN@1224|Proteobacteria,1RRVJ@1236|Gammaproteobacteria,1XNBD@135619|Oceanospirillales 135619|Oceanospirillales M DegT/DnrJ/EryC1/StrS aminotransferase family - - - - - - - - - - - - DegT_DnrJ_EryC1 k59_749571_2 1395571.TMS3_0121365 3.66e-29 118.0 COG1794@1|root,COG1794@2|Bacteria,1MV03@1224|Proteobacteria,1T08I@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Asp/Glu/Hydantoin racemase - - 5.1.1.13 ko:K01779 ko00250,ko01054,map00250,map01054 - R00491 RC00302 ko00000,ko00001,ko01000 - - - Asp_Glu_race k59_1371784_1 1229753.K7QL65_9CAUD 1.46e-63 203.0 4QCHF@10239|Viruses,4QW57@35237|dsDNA viruses no RNA stage,4QPIH@28883|Caudovirales,4QHVS@10662|Myoviridae 10662|Myoviridae S PhoH-like protein - - - - - - - - - - - - - k59_1371791_2 207954.MED92_11669 1.86e-48 161.0 COG3779@1|root,COG3779@2|Bacteria,1N69W@1224|Proteobacteria,1SNA7@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Uncharacterized protein conserved in bacteria (DUF2314) - - - - - - - - - - - - DUF2314 k59_410675_1 158500.BV97_03786 6.24e-91 275.0 COG0179@1|root,COG0179@2|Bacteria,1MUPF@1224|Proteobacteria,2TQQG@28211|Alphaproteobacteria,2K0DM@204457|Sphingomonadales 28211|Alphaproteobacteria Q 2-keto-4-pentenoate hydratase 2-oxohepta-3-ene-1,7-dioic acid hydratase - - - - - - - - - - - - DUF2437,FAA_hydrolase k59_636680_1 1265313.HRUBRA_00598 6.22e-05 45.8 COG1825@1|root,COG1825@2|Bacteria,1RDH0@1224|Proteobacteria,1S46A@1236|Gammaproteobacteria 1236|Gammaproteobacteria J This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance ctc GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02897 ko03010,map03010 M00178 - - ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L25p,Ribosomal_TL5_C k59_15506_1 1121121.KB894291_gene1507 2.7e-28 120.0 COG0300@1|root,COG2227@1|root,COG3321@1|root,COG4221@1|root,COG0300@2|Bacteria,COG2227@2|Bacteria,COG3321@2|Bacteria,COG4221@2|Bacteria 2|Bacteria IQ oxidoreductase activity pksR - 1.1.1.320 ko:K13611,ko:K13614,ko:K13615,ko:K16216 - - - - ko00000,ko01000,ko01004,ko01008 - - - ECH_1,KAsynt_C_assoc,KR,Ketoacyl-synt_C,Methyltransf_12,PP-binding,PS-DH,Thioesterase,adh_short,ketoacyl-synt k59_1597216_1 663610.JQKO01000016_gene1628 3.27e-81 250.0 COG0583@1|root,COG0583@2|Bacteria,1MUNN@1224|Proteobacteria,2VEUG@28211|Alphaproteobacteria,3NB3G@45404|Beijerinckiaceae 28211|Alphaproteobacteria K LysR substrate binding domain - - - - - - - - - - - - HTH_1,LysR_substrate k59_749585_1 83219.PM02_17630 1.52e-70 214.0 COG2963@1|root,COG2963@2|Bacteria,1RHKX@1224|Proteobacteria,2U9TV@28211|Alphaproteobacteria,3ZY1Y@60136|Sulfitobacter 28211|Alphaproteobacteria L Transposase - - - - - - - - - - - - HTH_Tnp_1 k59_749585_2 376733.IT41_17935 1.07e-92 278.0 COG2801@1|root,COG2963@1|root,COG2801@2|Bacteria,COG2963@2|Bacteria,1PBHA@1224|Proteobacteria,2TRQF@28211|Alphaproteobacteria,2PVTX@265|Paracoccus 28211|Alphaproteobacteria L Integrase core domain - - - ko:K07497 - - - - ko00000 - - - HTH_32,rve,rve_3 k59_72812_1 1122137.AQXF01000003_gene2245 4.51e-150 458.0 COG0145@1|root,COG0146@1|root,COG0145@2|Bacteria,COG0146@2|Bacteria,1MU2Y@1224|Proteobacteria,2TQZ6@28211|Alphaproteobacteria 28211|Alphaproteobacteria EQ N-methylhydantoinase A acetone carboxylase, beta subunit oplA - 3.5.2.9 ko:K01469 ko00480,map00480 - R00251 RC00553 ko00000,ko00001,ko01000 - - - Hydant_A_N,Hydantoinase_A,Hydantoinase_B k59_1654247_1 1380600.AUYN01000001_gene2545 6.59e-92 286.0 COG0471@1|root,COG0471@2|Bacteria,4NF52@976|Bacteroidetes,1HWTJ@117743|Flavobacteriia 976|Bacteroidetes P Sodium:sulfate symporter transmembrane region - - - - - - - - - - - - CitMHS,Na_sulph_symp,TrkA_C k59_15545_1 1156919.QWC_15339 9.43e-16 77.0 COG1028@1|root,COG1028@2|Bacteria,1NTGG@1224|Proteobacteria,2WF5A@28216|Betaproteobacteria,3T5GJ@506|Alcaligenaceae 28216|Betaproteobacteria IQ KR domain - - - - - - - - - - - - adh_short_C2 k59_15545_2 682795.AciX8_3507 1.92e-18 87.0 COG0657@1|root,COG0657@2|Bacteria,3Y7N2@57723|Acidobacteria 57723|Acidobacteria G alpha/beta hydrolase fold - - - - - - - - - - - - Abhydrolase_3 k59_1258052_1 555793.WSK_0301 1.32e-35 135.0 COG0457@1|root,COG0457@2|Bacteria,1R6NC@1224|Proteobacteria,2TTYU@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Tetratricopeptide repeat - - - - - - - - - - - - - k59_1484975_1 864702.OsccyDRAFT_3746 2.9e-60 203.0 COG1222@1|root,COG1222@2|Bacteria,1G1TR@1117|Cyanobacteria,1H87N@1150|Oscillatoriales 2|Bacteria O PFAM ATPase family associated with various cellular activities (AAA) - - - - - - - - - - - - AAA,ClpS k59_1484977_1 575540.Isop_3045 3.02e-42 144.0 COG0457@1|root,COG0457@2|Bacteria,2IZQ0@203682|Planctomycetes 203682|Planctomycetes S PFAM type I phosphodiesterase nucleotide pyrophosphatase - - - - - - - - - - - - Phosphodiest k59_1144877_1 875328.JDM601_3447 1.98e-71 223.0 COG2141@1|root,COG2141@2|Bacteria,2H0K9@201174|Actinobacteria,2339V@1762|Mycobacteriaceae 201174|Actinobacteria C COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - - - - - - - - - - Bac_luciferase k59_636721_2 1096930.L284_15190 9.15e-46 164.0 COG4581@1|root,COG4581@2|Bacteria,1MVD6@1224|Proteobacteria,2TR7N@28211|Alphaproteobacteria,2JZXM@204457|Sphingomonadales 204457|Sphingomonadales L helicase - - 3.6.4.13 ko:K17675 - - - - ko00000,ko01000,ko03029 - - - Helicase_C k59_919204_1 1385935.N836_21945 2.79e-41 150.0 COG1322@1|root,COG1322@2|Bacteria,1GDJN@1117|Cyanobacteria 1117|Cyanobacteria S RmuC family - - - - - - - - - - - - RmuC k59_1484994_1 76114.ebA1443 9.24e-46 160.0 COG0773@1|root,COG0773@2|Bacteria,1MV68@1224|Proteobacteria,2VIKZ@28216|Betaproteobacteria,2KVFZ@206389|Rhodocyclales 206389|Rhodocyclales M Belongs to the MurCDEF family murC - 6.3.2.8 ko:K01924 ko00471,ko00550,ko01100,map00471,map00550,map01100 - R03193 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_1484994_2 378806.STAUR_6262 4.28e-10 61.6 COG0707@1|root,COG0707@2|Bacteria,1MVIB@1224|Proteobacteria,42ME1@68525|delta/epsilon subdivisions,2WJNY@28221|Deltaproteobacteria,2YWEZ@29|Myxococcales 28221|Deltaproteobacteria M Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) murG - 2.4.1.227 ko:K02563 ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112 - R05032,R05662 RC00005,RC00049 ko00000,ko00001,ko01000,ko01011 - GT28 - Glyco_tran_28_C,Glyco_transf_28 k59_1258086_1 436308.Nmar_0832 1.11e-113 337.0 COG1253@1|root,arCOG00626@2157|Archaea,41T1G@651137|Thaumarchaeota 651137|Thaumarchaeota S Transporter associated domain - - - - - - - - - - - - CBS,CorC_HlyC,DUF21 k59_309298_2 84531.JMTZ01000022_gene4194 2.95e-116 347.0 COG0077@1|root,COG1605@1|root,COG0077@2|Bacteria,COG1605@2|Bacteria,1MU60@1224|Proteobacteria,1RNRD@1236|Gammaproteobacteria,1X4R7@135614|Xanthomonadales 135614|Xanthomonadales E Prephenate dehydratase pheA - 4.2.1.51,5.4.99.5 ko:K14170 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00024,M00025 R00691,R01373,R01715 RC00360,RC03116 ko00000,ko00001,ko00002,ko01000 - - - ACT,CM_2,PDT k59_874468_1 187272.Mlg_2874 5.23e-31 111.0 COG0636@1|root,32S3K@2|Bacteria,1N1NA@1224|Proteobacteria,1S9MD@1236|Gammaproteobacteria,1WYXA@135613|Chromatiales 135613|Chromatiales C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation atpE - - ko:K02110 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt_C k59_874468_2 1137799.GZ78_22295 2.47e-25 101.0 COG0356@1|root,COG0356@2|Bacteria,1MV87@1224|Proteobacteria,1RPHK@1236|Gammaproteobacteria,1XH68@135619|Oceanospirillales 135619|Oceanospirillales C it plays a direct role in the translocation of protons across the membrane atpB - - ko:K02108 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko03110 3.A.2.1 - - ATP-synt_A k59_1436333_1 1123279.ATUS01000003_gene414 1.08e-58 193.0 COG1684@1|root,COG1684@2|Bacteria,1NIF4@1224|Proteobacteria,1RMYW@1236|Gammaproteobacteria,1J68A@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria N Role in flagellar biosynthesis fliR - - ko:K02421 ko02040,map02040 - - - ko00000,ko00001,ko02035,ko02044 3.A.6.2 - - Bac_export_1 k59_1436333_2 566466.NOR53_12 5.83e-34 119.0 COG1987@1|root,COG1987@2|Bacteria,1N73W@1224|Proteobacteria,1SCBG@1236|Gammaproteobacteria,1J6WI@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria N Role in flagellar biosynthesis fliQ - - ko:K02420 ko02040,map02040 - - - ko00000,ko00001,ko02035,ko02044 3.A.6.2 - - Bac_export_3 k59_645659_1 500635.MITSMUL_03864 9.48e-65 207.0 COG1117@1|root,COG1117@2|Bacteria,1TP1M@1239|Firmicutes,4H2CK@909932|Negativicutes 909932|Negativicutes P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system pstB - 3.6.3.27 ko:K02036 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.7 - - ABC_tran k59_645659_2 246197.MXAN_6624 8.49e-44 152.0 COG1225@1|root,COG1225@2|Bacteria,1RD4R@1224|Proteobacteria,42RHG@68525|delta/epsilon subdivisions,2WQ59@28221|Deltaproteobacteria,2YV5F@29|Myxococcales 28221|Deltaproteobacteria O Redoxin prx-4 - 1.11.1.15 ko:K03564 - - - - ko00000,ko01000 - - - AhpC-TSA k59_531587_1 926569.ANT_15130 1.35e-26 104.0 COG1716@1|root,COG1716@2|Bacteria,2G9CS@200795|Chloroflexi 200795|Chloroflexi T PFAM Forkhead-associated protein - - - - - - - - - - - - FHA k59_1608380_1 748247.AZKH_3599 1.84e-62 215.0 COG1216@1|root,COG3119@1|root,COG1216@2|Bacteria,COG3119@2|Bacteria,1MV0B@1224|Proteobacteria,2VMN9@28216|Betaproteobacteria,2KVMN@206389|Rhodocyclales 206389|Rhodocyclales P Type I phosphodiesterase / nucleotide pyrophosphatase - - - - - - - - - - - - Glycos_transf_2,Sulfatase k59_309325_1 1229909.NSED_02175 9.46e-34 120.0 arCOG04033@1|root,arCOG04033@2157|Archaea,41SM5@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_309325_2 1229909.NSED_02170 1.98e-58 182.0 arCOG10524@1|root,arCOG10524@2157|Archaea,41SVP@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_139269_1 1122137.AQXF01000002_gene472 9.74e-111 328.0 COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,2TQQ7@28211|Alphaproteobacteria 28211|Alphaproteobacteria I Belongs to the thiolase family vraB - 2.3.1.16,2.3.1.9 ko:K00626,ko:K00632 ko00071,ko00072,ko00280,ko00281,ko00310,ko00362,ko00380,ko00592,ko00620,ko00630,ko00640,ko00642,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00281,map00310,map00362,map00380,map00592,map00620,map00630,map00640,map00642,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00087,M00088,M00095,M00113,M00373,M00374,M00375 R00238,R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095 RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N k59_420519_1 1122137.AQXF01000003_gene2277 2.54e-113 347.0 COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,2TR80@28211|Alphaproteobacteria 28211|Alphaproteobacteria P P-type ATPase' - - 3.6.3.4 ko:K01533 - - R00086 RC00002 ko00000,ko01000 3.A.3.5 - - ATPase-cat_bd,E1-E2_ATPase,HMA,Hydrolase k59_983831_1 1144275.COCOR_04260 1.5e-50 182.0 COG0642@1|root,COG0745@1|root,COG2202@1|root,COG0745@2|Bacteria,COG2202@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,42M0Y@68525|delta/epsilon subdivisions,2X791@28221|Deltaproteobacteria 28221|Deltaproteobacteria T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - GAF_2,HATPase_c,HisKA,Response_reg k59_1382580_1 1122194.AUHU01000015_gene2986 1.92e-34 132.0 COG4942@1|root,COG4942@2|Bacteria,1MY3E@1224|Proteobacteria,1RPQP@1236|Gammaproteobacteria,465VU@72275|Alteromonadaceae 1236|Gammaproteobacteria D COG4942 Membrane-bound metallopeptidase envC GO:0000920,GO:0001896,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008219,GO:0009273,GO:0009314,GO:0009628,GO:0009987,GO:0012501,GO:0016020,GO:0016787,GO:0030288,GO:0030313,GO:0031975,GO:0032153,GO:0042221,GO:0042493,GO:0042546,GO:0042597,GO:0043085,GO:0044085,GO:0044093,GO:0044464,GO:0050790,GO:0050896,GO:0051301,GO:0051336,GO:0051345,GO:0065007,GO:0065009,GO:0071554,GO:0071840,GO:0071944 - - - - - - - - - - Peptidase_M23 k59_1495940_1 158500.BV97_02337 2.57e-44 158.0 COG4993@1|root,COG4993@2|Bacteria,1MUQX@1224|Proteobacteria,2TS2Q@28211|Alphaproteobacteria,2K18E@204457|Sphingomonadales 204457|Sphingomonadales CG Dehydrogenase - - 1.1.2.8 ko:K00114 ko00010,ko00625,ko01100,ko01110,ko01120,ko01130,map00010,map00625,map01100,map01110,map01120,map01130 - R05062,R05198,R05285 RC00087,RC00088,RC01039 ko00000,ko00001,ko01000 - - - PQQ k59_590839_1 1122137.AQXF01000003_gene1934 9.24e-102 308.0 COG0014@1|root,COG0014@2|Bacteria,1MUGJ@1224|Proteobacteria,2TS83@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate proA GO:0003674,GO:0003824,GO:0004350,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0055114 1.2.1.41 ko:K00147 ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230 M00015 R03313 RC00684 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_590839_2 1122137.AQXF01000003_gene1935 3.6e-67 215.0 COG0263@1|root,COG0263@2|Bacteria,1MUBG@1224|Proteobacteria,2TRKB@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate proB - 2.7.2.11 ko:K00931 ko00330,ko00332,ko01100,ko01130,ko01230,map00330,map00332,map01100,map01130,map01230 M00015 R00239 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase,PUA k59_1323933_1 1144305.PMI02_04937 2.05e-70 219.0 COG2128@1|root,COG2128@2|Bacteria,1MVWP@1224|Proteobacteria,2VGCN@28211|Alphaproteobacteria,2K62F@204457|Sphingomonadales 204457|Sphingomonadales S Carboxymuconolactone decarboxylase family - - - - - - - - - - - - CMD k59_1268086_2 1254432.SCE1572_06500 1.57e-12 70.9 COG1418@1|root,COG1418@2|Bacteria,1RH6M@1224|Proteobacteria 1224|Proteobacteria S mRNA catabolic process - - - - - - - - - - - - - k59_140555_1 1144305.PMI02_00569 1.79e-72 226.0 COG1082@1|root,COG1082@2|Bacteria 2|Bacteria G myo-inosose-2 dehydratase activity - - - - - - - - - - - - AP_endonuc_2 k59_1722522_1 1005048.CFU_0207 3.52e-55 189.0 COG1012@1|root,COG1012@2|Bacteria,1MVGW@1224|Proteobacteria,2VI2E@28216|Betaproteobacteria,476VA@75682|Oxalobacteraceae 28216|Betaproteobacteria C Aldehyde dehydrogenase family calB - 1.2.1.3,1.2.1.68 ko:K00128,ko:K00154 ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130 M00135 R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146 RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_1664675_1 1003200.AXXA_01110 1.44e-62 214.0 COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,2VM2H@28216|Betaproteobacteria,3T57X@506|Alcaligenaceae 28216|Betaproteobacteria L Superfamily I DNA and RNA helicases pcrA - 3.6.4.12 ko:K03657 ko03420,ko03430,map03420,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - UvrD-helicase,UvrD_C k59_759341_2 1122137.AQXF01000007_gene3605 9.12e-43 159.0 COG2352@1|root,COG2352@2|Bacteria 2|Bacteria C phosphoenolpyruvate carboxylase activity - - 4.1.1.31 ko:K01595 ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200 M00168,M00170,M00171,M00172,M00173,M00346,M00374 R00345 RC02741 ko00000,ko00001,ko00002,ko01000 - - - PEPcase k59_815917_1 1123368.AUIS01000015_gene2634 6.69e-51 176.0 COG0144@1|root,COG0144@2|Bacteria,1MWPE@1224|Proteobacteria,1RN8X@1236|Gammaproteobacteria,2NC3R@225057|Acidithiobacillales 225057|Acidithiobacillales J Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA - - 2.1.1.176 ko:K03500 - - - - ko00000,ko01000,ko03009 - - - Methyltr_RsmB-F,NusB k59_1775668_1 926554.KI912633_gene3717 2.44e-107 340.0 COG3383@1|root,COG3383@2|Bacteria,1WJDD@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus C TIGRFAM formate dehydrogenase, alpha subunit, archaeal-type - - 1.17.1.9 ko:K00123 ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200 - R00519 RC02796 ko00000,ko00001,ko01000 - - - Fer2_4,Fer4,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3 k59_759347_1 1268239.PALB_16620 7.44e-141 415.0 COG0422@1|root,COG0422@2|Bacteria,1MUVV@1224|Proteobacteria,1RP1F@1236|Gammaproteobacteria,2Q0E7@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria H Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction thiC GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.99.17 ko:K03147 ko00730,ko01100,map00730,map01100 M00127 R03472 RC03251,RC03252 ko00000,ko00001,ko00002,ko01000 - - iECABU_c1320.ECABU_c45100 ThiC-associated,ThiC_Rad_SAM k59_1156155_1 1415778.JQMM01000001_gene1804 3.13e-87 271.0 COG0508@1|root,COG0508@2|Bacteria,1MUJD@1224|Proteobacteria,1RME0@1236|Gammaproteobacteria,1J4PD@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) sucB GO:0003674,GO:0003824,GO:0004149,GO:0005488,GO:0005504,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0008289,GO:0009060,GO:0009987,GO:0015980,GO:0016417,GO:0016740,GO:0016746,GO:0016747,GO:0016748,GO:0016751,GO:0016999,GO:0017144,GO:0019752,GO:0031405,GO:0031406,GO:0032991,GO:0033293,GO:0036094,GO:0043167,GO:0043168,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045239,GO:0045240,GO:0045252,GO:0045333,GO:0048037,GO:0050662,GO:0055114,GO:0071704,GO:0072350,GO:0097159,GO:0140096,GO:1901363,GO:1901681,GO:1902494,GO:1990204,GO:1990234 2.3.1.61 ko:K00658 ko00020,ko00310,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00032 R02570,R02571,R08549 RC00004,RC02727,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - iAPECO1_1312.APECO1_1352,iECED1_1282.ECED1_0696,iECOK1_1307.ECOK1_0726,iECS88_1305.ECS88_0752,iLF82_1304.LF82_2196,iNRG857_1313.NRG857_03235,iUMN146_1321.UM146_13990,iUTI89_1310.UTI89_C0722 2-oxoacid_dh,Biotin_lipoyl,E3_binding k59_477049_1 498211.CJA_2706 1.13e-77 259.0 COG1501@1|root,COG1501@2|Bacteria,1MWNJ@1224|Proteobacteria,1RMJ9@1236|Gammaproteobacteria,1FI21@10|Cellvibrio 1236|Gammaproteobacteria G Domain of unknown function (DUF5110) xylS - 3.2.1.177 ko:K01811 - - - - ko00000,ko01000 - GH31 - DUF4968,DUF5110,Glyco_hydro_31,PA14 k59_1664701_2 1123514.KB905899_gene452 2.53e-20 94.7 COG3407@1|root,COG3407@2|Bacteria,1N5EZ@1224|Proteobacteria,1S19T@1236|Gammaproteobacteria,461M8@72273|Thiotrichales 72273|Thiotrichales I GHMP kinases N terminal domain - - 4.1.1.33 ko:K01597 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00095 R01121 RC00453 ko00000,ko00001,ko00002,ko01000 - - - GHMP_kinases_N k59_195313_1 1122137.AQXF01000004_gene1851 1.85e-94 285.0 COG0216@1|root,COG0216@2|Bacteria,1MV28@1224|Proteobacteria,2TQSV@28211|Alphaproteobacteria 28211|Alphaproteobacteria J Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA prfA - - ko:K02835 - - - - ko00000,ko03012 - - - PCRF,RF-1 k59_195313_2 1122137.AQXF01000004_gene1850 2.72e-155 447.0 COG0124@1|root,COG0124@2|Bacteria,1MV2K@1224|Proteobacteria,2TSTH@28211|Alphaproteobacteria 28211|Alphaproteobacteria J histidyl-tRNA synthetase hisS - 6.1.1.21 ko:K01892 ko00970,map00970 M00359,M00360 R03655 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,tRNA-synt_His k59_1383970_1 265072.Mfla_1872 1.83e-73 233.0 COG1187@1|root,COG1187@2|Bacteria,1MUCE@1224|Proteobacteria,2VITB@28216|Betaproteobacteria,2KKN3@206350|Nitrosomonadales 206350|Nitrosomonadales J Belongs to the pseudouridine synthase RsuA family - - 5.4.99.22 ko:K06178 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2,S4 k59_28101_1 702113.PP1Y_AT21948 7.43e-83 266.0 COG0642@1|root,COG2205@2|Bacteria,1QVQF@1224|Proteobacteria,2TWX1@28211|Alphaproteobacteria,2KEEV@204457|Sphingomonadales 204457|Sphingomonadales T Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - - - - - - - - - - GAF,HATPase_c k59_1497420_1 1122137.AQXF01000004_gene1824 1.15e-105 313.0 COG4974@1|root,COG4974@2|Bacteria,1MVNF@1224|Proteobacteria,2TRAA@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Belongs to the 'phage' integrase family xerD - - ko:K04763 - - - - ko00000,ko03036 - - - Phage_int_SAM_1,Phage_integrase k59_421511_1 1232428.CAVO010000016_gene902 8.61e-05 50.4 COG0793@1|root,COG0793@2|Bacteria,1TPBI@1239|Firmicutes,4H27I@909932|Negativicutes 909932|Negativicutes M Belongs to the peptidase S41A family ctpA - 3.4.21.102 ko:K03797 - - - - ko00000,ko01000,ko01002 - - - PDZ,PDZ_2,Peptidase_S41 k59_252938_1 990285.RGCCGE502_25563 4.28e-19 78.6 COG1278@1|root,COG1278@2|Bacteria,1N6Q5@1224|Proteobacteria,2UF6W@28211|Alphaproteobacteria,4BG0X@82115|Rhizobiaceae 28211|Alphaproteobacteria K Cold shock cspA1 - - ko:K03704 - - - - ko00000,ko03000 - - - CSD k59_252938_2 314278.NB231_11954 5.75e-08 52.4 COG0824@1|root,COG0824@2|Bacteria,1MZTU@1224|Proteobacteria,1S7VY@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Thioesterase fcbC - - ko:K07107 - - - - ko00000,ko01000 - - - 4HBT,4HBT_2 k59_477076_1 1380394.JADL01000008_gene3473 4.5e-112 336.0 COG2816@1|root,COG2816@2|Bacteria,1MV1F@1224|Proteobacteria,2TTRT@28211|Alphaproteobacteria,2JQZX@204441|Rhodospirillales 204441|Rhodospirillales L COG1180 Pyruvate-formate lyase-activating enzyme - - - - - - - - - - - - - k59_1383993_1 1121374.KB891575_gene1102 3.3e-91 286.0 COG0457@1|root,COG0457@2|Bacteria,1MVMG@1224|Proteobacteria,1RU5N@1236|Gammaproteobacteria 1236|Gammaproteobacteria K COG0457 FOG TPR repeat - - - - - - - - - - - - Sulfotransfer_3,TPR_16,TPR_8 k59_1268137_1 675806.VII_001501 7.8e-91 273.0 COG3022@1|root,COG3022@2|Bacteria,1MUAF@1224|Proteobacteria,1RMTD@1236|Gammaproteobacteria,1XUFU@135623|Vibrionales 135623|Vibrionales S Belongs to the UPF0246 family yaaA GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006979,GO:0008150,GO:0033194,GO:0042221,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:1901700 - ko:K09861 - - - - ko00000 - - - H2O2_YaaD k59_1722584_1 266117.Rxyl_2464 1.66e-115 351.0 COG0439@1|root,COG0439@2|Bacteria,2I2S0@201174|Actinobacteria,4CP7I@84995|Rubrobacteria 84995|Rubrobacteria I Carbamoyl-phosphate synthase L chain, ATP-binding Carbamoyl-phosphate synthetase large chain-like biotin carboxylase-like - - 6.3.4.14,6.4.1.2,6.4.1.3 ko:K11263 ko00061,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00741 R00742,R01859,R04385 RC00040,RC00097,RC00253,RC00367,RC00609 ko00000,ko00001,ko00002,ko01000 - - - Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2 k59_85235_1 391615.ABSJ01000030_gene806 1.89e-50 172.0 COG1354@1|root,COG1354@2|Bacteria,1MVCN@1224|Proteobacteria,1RNBB@1236|Gammaproteobacteria,1J4MQ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria D Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves scpA - - ko:K05896 - - - - ko00000,ko03036 - - - SMC_ScpA k59_1664727_1 1122137.AQXF01000003_gene2450 1.05e-82 249.0 COG0207@1|root,COG0207@2|Bacteria,1MUBD@1224|Proteobacteria,2TQSB@28211|Alphaproteobacteria 28211|Alphaproteobacteria F Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis thyA - 2.1.1.45 ko:K00560 ko00240,ko00670,ko01100,ko01523,map00240,map00670,map01100,map01523 M00053 R02101 RC00219,RC00332 ko00000,ko00001,ko00002,ko01000 - - - Thymidylat_synt k59_1664727_2 1121948.AUAC01000009_gene511 3.4e-28 109.0 COG3000@1|root,COG3000@2|Bacteria,1R48K@1224|Proteobacteria,2U4WF@28211|Alphaproteobacteria,43YS7@69657|Hyphomonadaceae 28211|Alphaproteobacteria I Fatty acid hydroxylase superfamily - - - - - - - - - - - - FA_hydroxylase k59_1437401_1 358823.DF19_03585 3.9e-70 233.0 COG0366@1|root,COG0366@2|Bacteria,2GJKR@201174|Actinobacteria 201174|Actinobacteria G Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB glgE - 2.4.99.16 ko:K16147 ko00500,ko01100,map00500,map01100 - R09994 - ko00000,ko00001,ko01000 - GH13 - Alpha-amylase,DUF3416 k59_421518_1 1218352.B597_021000 1.3e-39 144.0 COG2267@1|root,COG2267@2|Bacteria,1QUZX@1224|Proteobacteria,1S4PV@1236|Gammaproteobacteria 1236|Gammaproteobacteria I Alpha beta hydrolase - - - - - - - - - - - - Abhydrolase_1,Abhydrolase_6,Hydrolase_4 k59_1156207_1 768066.HELO_1429 1.36e-30 120.0 COG0598@1|root,COG0598@2|Bacteria,1MX09@1224|Proteobacteria,1T05M@1236|Gammaproteobacteria,1XNUY@135619|Oceanospirillales 135619|Oceanospirillales P CorA-like Mg2+ transporter protein corA - - ko:K03284 - - - - ko00000,ko02000 1.A.35.1,1.A.35.3 - - CorA k59_1384006_1 565045.NOR51B_1247 7.5e-70 222.0 COG1741@1|root,COG1741@2|Bacteria,1MWIP@1224|Proteobacteria,1RS05@1236|Gammaproteobacteria,1J4JW@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Belongs to the pirin family - - - ko:K06911 - - - - ko00000 - - - Pirin,Pirin_C k59_1722592_1 1089552.KI911559_gene293 2.04e-73 239.0 COG0747@1|root,COG0747@2|Bacteria,1MU3P@1224|Proteobacteria,2TT4M@28211|Alphaproteobacteria,2JQ75@204441|Rhodospirillales 204441|Rhodospirillales E Bacterial extracellular solute-binding proteins, family 5 Middle - - - ko:K02035 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - SBP_bac_5 k59_705570_2 547042.BACCOPRO_03362 8.31e-30 123.0 COG0569@1|root,COG2985@1|root,COG0569@2|Bacteria,COG2985@2|Bacteria,4NEBW@976|Bacteroidetes,2FMDF@200643|Bacteroidia,4AKJA@815|Bacteroidaceae 976|Bacteroidetes P Psort location CytoplasmicMembrane, score 10.00 - - - ko:K07085 - - - - ko00000 2.A.81 - - Asp-Al_Ex,TrkA_C k59_1775707_1 314287.GB2207_07537 4.72e-131 395.0 COG1884@1|root,COG1884@2|Bacteria,1MUXX@1224|Proteobacteria,1RSHX@1236|Gammaproteobacteria,1J4JG@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria I COG1884 Methylmalonyl-CoA mutase, N-terminal domain subunit scpA GO:0003674,GO:0003824,GO:0004494,GO:0005488,GO:0008144,GO:0016853,GO:0016866,GO:0019842,GO:0031419,GO:0036094,GO:0046906,GO:0048037,GO:0097159,GO:1901363 5.4.99.2 ko:K01847,ko:K01848 ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200 M00373,M00375,M00376,M00741 R00833 RC00395 ko00000,ko00001,ko00002,ko01000 - - iECO111_1330.ECO111_3653,iECO26_1355.ECO26_4004 B12-binding,MM_CoA_mutase k59_1609862_1 1125863.JAFN01000001_gene3521 2.08e-21 88.6 COG5401@1|root,COG5401@2|Bacteria,1NA0G@1224|Proteobacteria,42V1V@68525|delta/epsilon subdivisions,2WRCV@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Sporulation and spore germination - - - - - - - - - - - - Germane k59_1609862_2 1125863.JAFN01000001_gene3522 1.86e-57 194.0 COG0480@1|root,COG0480@2|Bacteria,1MUCV@1224|Proteobacteria,42M4T@68525|delta/epsilon subdivisions,2WIM7@28221|Deltaproteobacteria 68525|delta/epsilon subdivisions J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome - - - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2 k59_477097_1 1049564.TevJSym_ap00750 1.16e-55 183.0 COG3118@1|root,COG3118@2|Bacteria,1MV0R@1224|Proteobacteria,1RMSQ@1236|Gammaproteobacteria,1J6GX@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O Thioredoxin ybbN GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0008150,GO:0008152,GO:0009987,GO:0015035,GO:0015036,GO:0016491,GO:0016667,GO:0044424,GO:0044444,GO:0044464,GO:0055114,GO:0061077 - ko:K05838 - - - - ko00000,ko03110 - - - TPR_19,TPR_20,Thioredoxin k59_477097_2 95619.PM1_0223445 9.4e-05 45.4 COG1574@1|root,COG1574@2|Bacteria,1MWP2@1224|Proteobacteria 1224|Proteobacteria K Metal-dependent hydrolase with the TIM-barrel fold - - - - - - - - - - - - Amidohydro_3 k59_592288_1 391600.ABRU01000010_gene3162 7.5e-42 147.0 COG1352@1|root,COG1352@2|Bacteria,1MU6W@1224|Proteobacteria,2U1VY@28211|Alphaproteobacteria,2KHT6@204458|Caulobacterales 204458|Caulobacterales H Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP - - 2.1.1.80 ko:K00575 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko01000,ko02035 - - - CheR,CheR_N k59_85268_1 1121106.JQKB01000007_gene989 3.22e-49 167.0 COG0159@1|root,COG0159@2|Bacteria,1MXJV@1224|Proteobacteria,2TQN2@28211|Alphaproteobacteria,2JPR3@204441|Rhodospirillales 204441|Rhodospirillales E The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate trpA - 4.2.1.20 ko:K01695 ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230 M00023 R00674,R02340,R02722 RC00209,RC00210,RC00700,RC00701,RC02868 ko00000,ko00001,ko00002,ko01000 - - - Trp_syntA k59_1324977_1 1392490.JHZX01000001_gene2296 2.57e-139 416.0 COG1501@1|root,COG1501@2|Bacteria,4NE1H@976|Bacteroidetes,1HXZD@117743|Flavobacteriia 976|Bacteroidetes G Belongs to the glycosyl hydrolase 31 family - - 3.2.1.20 ko:K01187 ko00052,ko00500,ko01100,map00052,map00500,map01100 - R00028,R00801,R00802,R06087,R06088 RC00028,RC00049,RC00077 ko00000,ko00001,ko01000 - GH31 - DUF4968,DUF5110,Esterase,Gal_mutarotas_2,Glyco_hydro_31 k59_1554071_1 314278.NB231_16458 6.34e-55 194.0 COG1640@1|root,COG3280@1|root,COG1640@2|Bacteria,COG3280@2|Bacteria,1QTVJ@1224|Proteobacteria,1RMJW@1236|Gammaproteobacteria,1WWBR@135613|Chromatiales 135613|Chromatiales G PFAM glycoside hydrolase, family 77 - - 2.4.1.25 ko:K00705 ko00500,ko01100,map00500,map01100 - R05196 RC00049 ko00000,ko00001,ko01000 - GH77 - Glyco_hydro_77 k59_1384032_1 448385.sce7938 9.21e-59 184.0 COG0100@1|root,COG0100@2|Bacteria,1RD0A@1224|Proteobacteria,42R43@68525|delta/epsilon subdivisions,2WPH1@28221|Deltaproteobacteria,2YVAP@29|Myxococcales 28221|Deltaproteobacteria J Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome rpsK GO:0000028,GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0016070,GO:0016072,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034622,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0048027,GO:0065003,GO:0070181,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02948 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S11 k59_1384032_2 290397.Adeh_1920 1.29e-86 261.0 COG0522@1|root,COG0522@2|Bacteria,1MW0U@1224|Proteobacteria,42M5X@68525|delta/epsilon subdivisions,2WJGN@28221|Deltaproteobacteria,2YU1D@29|Myxococcales 28221|Deltaproteobacteria J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit rpsD GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006417,GO:0006450,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0015935,GO:0019222,GO:0019843,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0032991,GO:0034248,GO:0034250,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0045727,GO:0045903,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060255,GO:0065007,GO:0065008,GO:0080090,GO:0097159,GO:1901363,GO:1990904,GO:2000112 - ko:K02986 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S4,S4 k59_1384032_3 929794.CALV01000042_gene1251 4.83e-16 77.4 COG0202@1|root,COG0202@2|Bacteria,1MU75@1224|Proteobacteria,2TSI0@28211|Alphaproteobacteria,48TT5@772|Bartonellaceae 28211|Alphaproteobacteria K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoA GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006351,GO:0006354,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576 2.7.7.6 ko:K03040 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_A_CTD,RNA_pol_A_bac,RNA_pol_L k59_984911_1 1229909.NSED_00750 1.46e-63 195.0 COG0139@1|root,arCOG02676@2157|Archaea,41SPE@651137|Thaumarchaeota 651137|Thaumarchaeota E Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP hisI - 3.5.4.19 ko:K01496 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04037 RC01055 ko00000,ko00001,ko00002,ko01000 - - - PRA-CH k59_984911_2 1229909.NSED_00745 3.63e-107 314.0 COG0107@1|root,arCOG00617@2157|Archaea,41S9A@651137|Thaumarchaeota 651137|Thaumarchaeota E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit hisF - - ko:K02500 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04558 RC00010,RC01190,RC01943 ko00000,ko00001,ko00002,ko01000 - - - His_biosynth k59_310808_2 1183377.Py04_1339 7.38e-18 81.6 COG4608@1|root,arCOG00184@2157|Archaea,2Y5BH@28890|Euryarchaeota,243NN@183968|Thermococci 183968|Thermococci E Oligopeptide/dipeptide transporter, C-terminal region - - - ko:K02032 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - ABC_tran,oligo_HPY k59_759417_1 1282876.BAOK01000002_gene300 1.07e-78 246.0 COG0240@1|root,COG0240@2|Bacteria,1MUU3@1224|Proteobacteria,2TT75@28211|Alphaproteobacteria,4BP8N@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria C PFAM NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus gpsA GO:0003674,GO:0003824,GO:0006072,GO:0006629,GO:0006644,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0047952,GO:0052646,GO:0055114,GO:0071704,GO:0090407,GO:1901135,GO:1901576 1.1.1.94 ko:K00057 ko00564,ko01110,map00564,map01110 - R00842,R00844 RC00029 ko00000,ko00001,ko01000 - - - NAD_Gly3P_dh_C,NAD_Gly3P_dh_N k59_1783124_1 1150474.JQJI01000020_gene1559 5.29e-36 130.0 COG0639@1|root,COG0639@2|Bacteria,2GCVZ@200918|Thermotogae 200918|Thermotogae T PFAM metallophosphoesterase - - 3.1.3.16 ko:K07313 - - - - ko00000,ko01000 - - - Metallophos k59_1508205_1 1380600.AUYN01000006_gene283 5.4e-20 89.4 COG0773@1|root,COG0773@2|Bacteria,4NE1V@976|Bacteroidetes,1HX68@117743|Flavobacteriia 976|Bacteroidetes M Belongs to the MurCDEF family murC - 6.3.2.8 ko:K01924 ko00471,ko00550,ko01100,map00471,map00550,map01100 - R03193 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_1508205_2 1380600.AUYN01000006_gene284 1.82e-110 328.0 COG0707@1|root,COG0707@2|Bacteria,4NE6D@976|Bacteroidetes,1HXPU@117743|Flavobacteriia 976|Bacteroidetes M Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) murG - 2.4.1.227 ko:K02563 ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112 - R05032,R05662 RC00005,RC00049 ko00000,ko00001,ko01000,ko01011 - GT28 - Glyco_tran_28_C,Glyco_transf_28 k59_1055249_1 314285.KT71_03815 4.64e-17 88.2 COG3209@1|root,COG3209@2|Bacteria,1MVV1@1224|Proteobacteria,1RP75@1236|Gammaproteobacteria,1J6H5@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M silverDB - - - - - - - - - - - - DUF11,RHS_repeat k59_886982_1 1122609.AUGT01000009_gene3342 1.44e-55 184.0 COG4638@1|root,COG4638@2|Bacteria,2GKJY@201174|Actinobacteria,4DU3K@85009|Propionibacteriales 201174|Actinobacteria P Ring hydroxylating alpha subunit (catalytic domain) - - - ko:K00479 - - - - ko00000 - - - Rieske,Ring_hydroxyl_A k59_1618652_1 330214.NIDE4355 2.73e-89 273.0 COG0436@1|root,COG0436@2|Bacteria,3J0EV@40117|Nitrospirae 2|Bacteria E Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - ko:K10907 - - - - ko00000,ko01000,ko01007 - - - Aminotran_1_2 k59_1333149_1 1279017.AQYJ01000020_gene1227 7.49e-50 168.0 COG0042@1|root,COG0042@2|Bacteria,1MV5V@1224|Proteobacteria,1RMJP@1236|Gammaproteobacteria,464KZ@72275|Alteromonadaceae 1236|Gammaproteobacteria J Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines dusB GO:0002943,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009314,GO:0009451,GO:0009628,GO:0009987,GO:0010467,GO:0016070,GO:0016491,GO:0016627,GO:0017150,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0050896,GO:0055114,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 - ko:K05540 - - - - ko00000,ko01000,ko03016 - - - Dus k59_1333149_2 1117647.M5M_15620 6.03e-18 77.8 COG2901@1|root,COG2901@2|Bacteria,1N7MJ@1224|Proteobacteria,1SD35@1236|Gammaproteobacteria,1J6UC@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria K Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters fis GO:0000018,GO:0000229,GO:0000785,GO:0000786,GO:0000787,GO:0000789,GO:0000976,GO:0000984,GO:0000985,GO:0001017,GO:0001046,GO:0001047,GO:0001067,GO:0001121,GO:0001130,GO:0001131,GO:0001140,GO:0001216,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005694,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008301,GO:0009058,GO:0009059,GO:0009314,GO:0009628,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0016032,GO:0016070,GO:0018130,GO:0019042,GO:0019045,GO:0019046,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0031421,GO:0032359,GO:0032774,GO:0032991,GO:0032993,GO:0034641,GO:0034645,GO:0034654,GO:0042802,GO:0042803,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043565,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044374,GO:0044403,GO:0044419,GO:0044422,GO:0044424,GO:0044427,GO:0044444,GO:0044446,GO:0044464,GO:0044815,GO:0045892,GO:0045893,GO:0045911,GO:0045934,GO:0045935,GO:0046483,GO:0046983,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051054,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0051704,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2001141 - ko:K03557 ko05111,map05111 - - - ko00000,ko00001,ko03000,ko03036,ko03400 - - - HTH_8 k59_1107692_1 998088.B565_2216 3.59e-78 258.0 COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,1RPCB@1236|Gammaproteobacteria,1Y3XV@135624|Aeromonadales 135624|Aeromonadales O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner lon - 3.4.21.53 ko:K01338 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - AAA,LON_substr_bdg,Lon_C k59_540443_1 36080.S2JSJ2 4.74e-31 122.0 COG0463@1|root,KOG2977@2759|Eukaryota,38DUD@33154|Opisthokonta,3NTZC@4751|Fungi,1GSGM@112252|Fungi incertae sedis 4751|Fungi M Glycosyl transferase family 2 ALG5 GO:0003674,GO:0003824,GO:0004581,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005783,GO:0005789,GO:0006464,GO:0006486,GO:0006487,GO:0006488,GO:0006490,GO:0006629,GO:0006807,GO:0008150,GO:0008152,GO:0008194,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009987,GO:0012505,GO:0016020,GO:0016021,GO:0016740,GO:0016757,GO:0016758,GO:0018193,GO:0018196,GO:0018279,GO:0019538,GO:0030176,GO:0031224,GO:0031227,GO:0031984,GO:0034645,GO:0035251,GO:0036211,GO:0042175,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044422,GO:0044424,GO:0044425,GO:0044432,GO:0044444,GO:0044446,GO:0044464,GO:0046527,GO:0070085,GO:0071704,GO:0098827,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 2.4.1.117 ko:K00729 ko00510,ko01100,map00510,map01100 M00055 R01005 RC00005 ko00000,ko00001,ko00002,ko01000,ko01003 - GT2 - Glycos_transf_2 k59_1565696_1 458817.Shal_2252 8.5e-24 98.2 COG0583@1|root,COG0583@2|Bacteria,1N663@1224|Proteobacteria,1RMFD@1236|Gammaproteobacteria,2Q9X7@267890|Shewanellaceae 1236|Gammaproteobacteria K PFAM regulatory protein, LysR - - - - - - - - - - - - HTH_1,LysR_substrate k59_1565696_2 1123279.ATUS01000001_gene2771 1.02e-08 55.8 COG2225@1|root,COG2225@2|Bacteria,1MVEV@1224|Proteobacteria,1RPVI@1236|Gammaproteobacteria,1J4QN@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA glcB GO:0000287,GO:0003674,GO:0003824,GO:0004474,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009056,GO:0009060,GO:0009436,GO:0009987,GO:0015980,GO:0016054,GO:0016740,GO:0016746,GO:0016999,GO:0017144,GO:0019752,GO:0032787,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0046185,GO:0046395,GO:0046487,GO:0046872,GO:0046912,GO:0055114,GO:0071704,GO:0072329,GO:0072350,GO:1901575 2.3.3.9 ko:K01638 ko00620,ko00630,ko01100,ko01110,ko01120,ko01200,map00620,map00630,map01100,map01110,map01120,map01200 M00012 R00472 RC00004,RC00308,RC02747 ko00000,ko00001,ko00002,ko01000 - - iECSF_1327.ECSF_2799,iECW_1372.ECW_m3242,iEKO11_1354.EKO11_0745,iJN746.PP_0356,iWFL_1372.ECW_m3242 Malate_synthase k59_603802_1 1122137.AQXF01000001_gene3354 1.99e-61 198.0 COG3118@1|root,COG3118@2|Bacteria,1MV0R@1224|Proteobacteria,2TS5X@28211|Alphaproteobacteria 28211|Alphaproteobacteria O Thioredoxin trxA2 - - ko:K03671,ko:K05838 ko04621,ko05418,map04621,map05418 - - - ko00000,ko00001,ko03110 - - - TPR_19,TPR_20,Thioredoxin k59_603802_2 1121033.AUCF01000015_gene1470 8.09e-50 165.0 COG3760@1|root,COG3760@2|Bacteria,1RDIG@1224|Proteobacteria,2U87T@28211|Alphaproteobacteria,2JSRQ@204441|Rhodospirillales 204441|Rhodospirillales S Aminoacyl-tRNA editing domain - - - ko:K19055 - - - - ko00000,ko01000,ko03016 - - - tRNA_edit k59_993352_1 743721.Psesu_2007 5.75e-07 52.8 COG1399@1|root,COG1399@2|Bacteria,1PSXM@1224|Proteobacteria,1SWVC@1236|Gammaproteobacteria,1X6K9@135614|Xanthomonadales 135614|Xanthomonadales S ACR protein - - - ko:K07040 - - - - ko00000 - - - DUF177 k59_993352_2 891974.E05_36820 5.88e-11 57.4 COG0333@1|root,COG0333@2|Bacteria,1N6RF@1224|Proteobacteria,1SC9G@1236|Gammaproteobacteria,282TS@191675|unclassified Enterobacteriaceae 1236|Gammaproteobacteria J Belongs to the bacterial ribosomal protein bL32 family rpmF GO:0000027,GO:0000302,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006950,GO:0006979,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009628,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042221,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0050896,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1901700,GO:1990904 - ko:K02911 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011,ko03029 - - - Ribosomal_L32p k59_148954_1 316407.4062690 6.47e-259 712.0 COG4591@1|root,COG4591@2|Bacteria,1MVV7@1224|Proteobacteria,1RMP9@1236|Gammaproteobacteria,3XNMR@561|Escherichia 1236|Gammaproteobacteria M system transmembrane protein lolE lolE GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008104,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0032991,GO:0033036,GO:0034613,GO:0044425,GO:0044459,GO:0044464,GO:0044872,GO:0044873,GO:0044874,GO:0051179,GO:0051641,GO:0070727,GO:0071944,GO:0072657,GO:0098796,GO:0098797 - ko:K09808 ko02010,map02010 M00255 - - ko00000,ko00001,ko00002,ko02000 3.A.1.125 - - FtsX,MacB_PCD k59_716861_1 314278.NB231_00350 1.38e-36 135.0 COG0053@1|root,COG0053@2|Bacteria,1MVH8@1224|Proteobacteria,1RQ3E@1236|Gammaproteobacteria,1WY4U@135613|Chromatiales 135613|Chromatiales P PFAM Cation efflux - - - - - - - - - - - - Cation_efflux,ZT_dimer k59_1731119_1 1415778.JQMM01000001_gene1591 5.31e-115 337.0 COG0331@1|root,COG0331@2|Bacteria,1MV6N@1224|Proteobacteria,1RNH3@1236|Gammaproteobacteria,1J5AJ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria I COG0331 (acyl-carrier-protein) S-malonyltransferase fabD GO:0003674,GO:0003824,GO:0004312,GO:0004314,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016417,GO:0016419,GO:0016420,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0072330,GO:1901576 2.3.1.39 ko:K00645 ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212 M00082 R01626,R11671 RC00004,RC00039,RC02727 ko00000,ko00001,ko00002,ko01000,ko01004 - - iEcE24377_1341.EcE24377A_1213,iJN746.PP_1913,iPC815.YPO1598 Acyl_transf_1 k59_1107700_1 1122169.AREN01000005_gene1769 0.000452 44.3 COG1748@1|root,COG1748@2|Bacteria,1MY1G@1224|Proteobacteria,1RRUZ@1236|Gammaproteobacteria,1JD4N@118969|Legionellales 118969|Legionellales E Saccharopine dehydrogenase C-terminal domain lysDH - - - - - - - - - - - Sacchrp_dh_C,Sacchrp_dh_NADP k59_1107700_3 338966.Ppro_0851 2.27e-06 48.9 COG0055@1|root,COG0055@2|Bacteria,1N6UZ@1224|Proteobacteria 1224|Proteobacteria C Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits - - 3.6.3.14 ko:K02112 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - - ATP-synt_ab,ATP-synt_ab_N k59_206534_1 313603.FB2170_09681 2.26e-52 184.0 COG1884@1|root,COG1884@2|Bacteria,4NDVE@976|Bacteroidetes,1HXB9@117743|Flavobacteriia,2PGEG@252356|Maribacter 976|Bacteroidetes I Methylmalonyl-CoA mutase mutA - 5.4.99.2 ko:K01847 ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200 M00373,M00376,M00741 R00833 RC00395 ko00000,ko00001,ko00002,ko01000 - - - MM_CoA_mutase k59_1565708_1 1415778.JQMM01000001_gene142 5.21e-29 110.0 COG3159@1|root,COG3159@2|Bacteria,1R4BP@1224|Proteobacteria,1S9SC@1236|Gammaproteobacteria,1J612@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S protein conserved in bacteria yigA - - ko:K09921 - - - - ko00000 - - - DUF484 k59_1565708_2 1415778.JQMM01000001_gene143 1.09e-11 65.5 COG4973@1|root,COG4973@2|Bacteria,1MUJJ@1224|Proteobacteria,1RMJG@1236|Gammaproteobacteria,1J4JX@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria D Belongs to the 'phage' integrase family. XerC subfamily xerC GO:0000150,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006276,GO:0006310,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008907,GO:0009009,GO:0009037,GO:0009987,GO:0015074,GO:0032991,GO:0034641,GO:0042150,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0048476,GO:0071139,GO:0071704,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363 - ko:K03733 - - - - ko00000,ko03036 - - - Phage_int_SAM_1,Phage_integrase k59_603821_2 314287.GB2207_01177 1.25e-31 119.0 COG2825@1|root,COG2825@2|Bacteria,1PSPN@1224|Proteobacteria,1SWU4@1236|Gammaproteobacteria,1J6SX@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Outer membrane protein (OmpH-like) - - - ko:K06142 - - - - ko00000 - - - OmpH k59_485496_1 392499.Swit_2399 1.53e-71 239.0 COG1410@1|root,COG1410@2|Bacteria,1MV6G@1224|Proteobacteria,2TQTG@28211|Alphaproteobacteria,2K0JK@204457|Sphingomonadales 204457|Sphingomonadales E 5-methyltetrahydrofolate--homocysteine methyltransferase metH - 2.1.1.13 ko:K00548 ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230 M00017 R00946,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 - - - B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind k59_826782_1 529818.AMSG_07273T0 2.34e-14 77.8 COG2226@1|root,KOG1540@2759|Eukaryota 2759|Eukaryota H 2-octaprenyl-6-methoxy-1,4-benzoquinone methylase activity UBIE - - - - - - - - - - - Ubie_methyltran k59_263727_1 469371.Tbis_2156 1.98e-72 242.0 COG0022@1|root,COG1071@1|root,COG0022@2|Bacteria,COG1071@2|Bacteria,2GNII@201174|Actinobacteria,4DYAF@85010|Pseudonocardiales 201174|Actinobacteria C Transketolase, pyrimidine binding domain - - 1.2.4.4 ko:K11381 ko00280,ko00640,ko01100,ko01110,ko01130,map00280,map00640,map01100,map01110,map01130 M00036 R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997 RC00027,RC00627,RC02743,RC02883,RC02949,RC02953 br01601,ko00000,ko00001,ko00002,ko01000 - - - E1_dh,Transket_pyr,Transketolase_C k59_1673014_1 391587.KAOT1_09576 1.1e-96 300.0 COG0366@1|root,COG0366@2|Bacteria,4NFMM@976|Bacteroidetes,1HZ0S@117743|Flavobacteriia 976|Bacteroidetes G Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB glgE - 2.4.99.16 ko:K16147 ko00500,ko01100,map00500,map01100 - R09994 - ko00000,ko00001,ko01000 - GH13 - Alpha-amylase,DUF3416 k59_263733_2 545264.KB898750_gene326 5.51e-41 146.0 COG2269@1|root,COG2269@2|Bacteria,1MU97@1224|Proteobacteria,1RMR9@1236|Gammaproteobacteria,1WW5X@135613|Chromatiales 135613|Chromatiales J Elongation factor P--(R)-beta-lysine ligase - - - ko:K04568 - - - - ko00000,ko01000,ko03012 - - - tRNA-synt_2 k59_429819_1 290400.Jann_1205 1.16e-13 69.3 COG3631@1|root,COG3631@2|Bacteria,1N487@1224|Proteobacteria,2UBRI@28211|Alphaproteobacteria 28211|Alphaproteobacteria S SnoaL-like domain - - - - - - - - - - - - SnoaL_2 k59_429819_2 448385.sce4627 1.97e-42 149.0 COG2378@1|root,COG2378@2|Bacteria,1MUTH@1224|Proteobacteria,43AJF@68525|delta/epsilon subdivisions,2X5ZP@28221|Deltaproteobacteria,2YZVA@29|Myxococcales 28221|Deltaproteobacteria K DeoR-like helix-turn-helix domain - - - - - - - - - - - - HTH_11,WYL k59_39081_1 1122179.KB890480_gene3086 2.76e-87 274.0 COG4145@1|root,COG4145@2|Bacteria,4PPNV@976|Bacteroidetes 976|Bacteroidetes H Sodium:solute symporter family - - - - - - - - - - - - SSF k59_603845_1 1109445.AGSX01000081_gene3034 3.95e-75 239.0 COG0161@1|root,COG0161@2|Bacteria,1MU2N@1224|Proteobacteria,1RP0C@1236|Gammaproteobacteria,1Z1BT@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria E Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family aptA - 2.6.1.18 ko:K00822 ko00280,ko00410,ko00640,ko01100,map00280,map00410,map00640,map01100 - R00907,R04187 RC00008,RC00062,RC00160 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_3 k59_263743_1 13690.CP98_04757 4.68e-96 306.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2TQT0@28211|Alphaproteobacteria,2KCZ7@204457|Sphingomonadales 204457|Sphingomonadales V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_1276263_2 136993.KB900626_gene1010 5.22e-12 71.6 COG3220@1|root,COG3220@2|Bacteria,1MURE@1224|Proteobacteria,2TRZJ@28211|Alphaproteobacteria,36ZBD@31993|Methylocystaceae 28211|Alphaproteobacteria S Protein of unknown function (DUF692) - - - ko:K09930 - - - - ko00000 - - - DUF692 k59_540475_1 1096930.L284_16710 3.72e-106 312.0 COG0483@1|root,COG0483@2|Bacteria,1MV4W@1224|Proteobacteria,2TV4R@28211|Alphaproteobacteria,2K171@204457|Sphingomonadales 204457|Sphingomonadales G Inositol monophosphatase - - 3.1.3.25 ko:K01092 ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070 M00131 R01185,R01186,R01187 RC00078 ko00000,ko00001,ko00002,ko01000 - - - Inositol_P k59_603849_2 1229909.NSED_00185 5.51e-48 163.0 COG0484@1|root,arCOG02846@2157|Archaea,41SCZ@651137|Thaumarchaeota 651137|Thaumarchaeota O DnaJ central domain - - - ko:K03686 - - - - ko00000,ko03029,ko03110 - - - DnaJ,DnaJ_C,DnaJ_CXXCXGXG k59_39089_1 485913.Krac_12226 2.55e-34 132.0 COG0438@1|root,COG0438@2|Bacteria 2|Bacteria M transferase activity, transferring glycosyl groups rfaG GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008194,GO:0008610,GO:0008653,GO:0008919,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033692,GO:0034637,GO:0034645,GO:0035251,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0046401,GO:0046527,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 - ko:K02844 ko00540,ko01100,map00540,map01100 M00080 - - ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT4 iSDY_1059.SDY_4061 Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1 k59_429834_1 314287.GB2207_02352 2.71e-79 246.0 COG0101@1|root,COG0101@2|Bacteria,1MUYI@1224|Proteobacteria,1RMK2@1236|Gammaproteobacteria,1J4NT@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs truA GO:0000049,GO:0001522,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016853,GO:0016866,GO:0031119,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363 5.4.99.12 ko:K06173 - - - - ko00000,ko01000,ko03016 - - - PseudoU_synth_1 k59_1446682_2 321327.CYA_0034 8.15e-17 79.0 COG2119@1|root,COG2119@2|Bacteria,1GGA4@1117|Cyanobacteria,1H49H@1129|Synechococcus 1117|Cyanobacteria S Uncharacterized protein family UPF0016 - - - - - - - - - - - - UPF0016 k59_39093_1 1144305.PMI02_01796 6.83e-09 55.1 COG0704@1|root,COG0704@2|Bacteria,1MUMI@1224|Proteobacteria,2TQMN@28211|Alphaproteobacteria,2K0AA@204457|Sphingomonadales 204457|Sphingomonadales P Plays a role in the regulation of phosphate uptake phoU GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009892,GO:0010563,GO:0010966,GO:0019220,GO:0019222,GO:0031323,GO:0031324,GO:0032879,GO:0034762,GO:0034763,GO:0034765,GO:0034766,GO:0042802,GO:0042803,GO:0043269,GO:0043271,GO:0044070,GO:0044424,GO:0044464,GO:0045936,GO:0046983,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051049,GO:0051051,GO:0051174,GO:0065007,GO:1903792,GO:1903795,GO:1903796,GO:1903959,GO:1903960,GO:2000185,GO:2000186 - ko:K02039 - - - - ko00000 - - - PhoU k59_39093_2 1144305.PMI02_01797 1.13e-76 234.0 COG1117@1|root,COG1117@2|Bacteria,1MU16@1224|Proteobacteria,2TQX9@28211|Alphaproteobacteria,2JZZN@204457|Sphingomonadales 204457|Sphingomonadales P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system pstB - 3.6.3.27 ko:K02036 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.7 - - ABC_tran k59_1618678_1 153948.NAL212_0619 1.06e-18 90.1 COG0823@1|root,COG0823@2|Bacteria,1MV09@1224|Proteobacteria,2VH9R@28216|Betaproteobacteria,372HA@32003|Nitrosomonadales 28216|Betaproteobacteria U Involved in the TonB-independent uptake of proteins tolB - - ko:K03641 - - - - ko00000,ko02000 2.C.1.2 - - PD40,TolB_N k59_1565750_1 1122197.ATWI01000011_gene355 0.000107 49.7 COG0790@1|root,COG0790@2|Bacteria 2|Bacteria S beta-lactamase activity - - - ko:K07126,ko:K19292 - - - - ko00000 - - - Sel1 k59_1565750_2 864051.BurJ1DRAFT_4161 2.57e-10 62.8 COG2010@1|root,COG2010@2|Bacteria,1R48P@1224|Proteobacteria,2VPF4@28216|Betaproteobacteria,1KN94@119065|unclassified Burkholderiales 28216|Betaproteobacteria C Cytochrome C oxidase, cbb3-type, subunit III - - - ko:K00406 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00156 - - ko00000,ko00001,ko00002 3.D.4.3 - - Cytochrome_CBB3 k59_993405_2 1229831.M832_01970 0.000193 43.9 COG0623@1|root,COG0623@2|Bacteria,2JFHT@204428|Chlamydiae 204428|Chlamydiae I Enoyl- acyl-carrier-protein reductase NADH fabI - 1.3.1.10,1.3.1.9 ko:K00208 ko00061,ko00333,ko00780,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01100,map01130,map01212 M00083,M00572 R01404,R04429,R04430,R04724,R04725,R04955,R04956,R04958,R04959,R04961,R04962,R04966,R04967,R04969,R04970,R07765,R10118,R10122,R11671 RC00052,RC00076,RC00120 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 k59_1167038_1 593117.TGAM_1902 1.14e-09 62.8 COG1030@1|root,arCOG01910@2157|Archaea,2XW1R@28890|Euryarchaeota,242U5@183968|Thermococci 183968|Thermococci O NfeD-like C-terminal, partner-binding - - - ko:K07403 - - - - ko00000 - - - CLP_protease,NfeD,SDH_sah k59_94687_2 1121920.AUAU01000022_gene2480 2.31e-98 305.0 COG2204@1|root,COG2204@2|Bacteria,3Y2J1@57723|Acidobacteria 57723|Acidobacteria T two component, sigma54 specific, transcriptional regulator, Fis family - - - ko:K13599 ko02020,map02020 M00498 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_603862_1 1395571.TMS3_0110025 5.05e-16 75.9 COG1051@1|root,COG1051@2|Bacteria,1REBW@1224|Proteobacteria,1S3XB@1236|Gammaproteobacteria 1236|Gammaproteobacteria F ADP-Ribose Pyrophosphatase - - - - - - - - - - - - NUDIX,Nudix_N_2 k59_603862_2 207954.MED92_07401 3.34e-41 137.0 COG3323@1|root,COG3323@2|Bacteria,1MZF5@1224|Proteobacteria,1S8WV@1236|Gammaproteobacteria,1XKGH@135619|Oceanospirillales 135619|Oceanospirillales S protein conserved in bacteria - - - - - - - - - - - - - k59_603862_3 1001530.BACE01000012_gene2553 4.26e-18 76.6 2EK1G@1|root,33DRY@2|Bacteria,1NH6C@1224|Proteobacteria,1SGMZ@1236|Gammaproteobacteria,1XYPN@135623|Vibrionales 135623|Vibrionales S Protein of unknown function (DUF3012) - - - - - - - - - - - - DUF3012 k59_655641_2 472175.EL18_00417 6.19e-12 66.2 COG0625@1|root,COG0625@2|Bacteria,1MUN3@1224|Proteobacteria,2TTVR@28211|Alphaproteobacteria 28211|Alphaproteobacteria O Belongs to the GST superfamily - - - ko:K11209 - - - - ko00000,ko01000 - - - GST_C,GST_N,GST_N_2,GST_N_3 k59_716917_1 487521.OCU_49660 2.32e-35 128.0 COG1028@1|root,COG1028@2|Bacteria,2GJ1F@201174|Actinobacteria,236AX@1762|Mycobacteriaceae 201174|Actinobacteria IQ Belongs to the short-chain dehydrogenases reductases (SDR) family - GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0018193,GO:0018205,GO:0019538,GO:0030312,GO:0032446,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0070490,GO:0070647,GO:0071704,GO:0071944,GO:1901564 - - - - - - - - - - adh_short k59_485533_1 504487.JCM19302_3434 8.07e-121 352.0 COG0621@1|root,COG0621@2|Bacteria,4NDU6@976|Bacteroidetes,1HX6T@117743|Flavobacteriia 976|Bacteroidetes J Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine miaB - 2.8.4.3 ko:K06168 - - R10645,R10646,R10647 RC00003,RC00980,RC03221,RC03222 ko00000,ko01000,ko03016 - - - Radical_SAM,TRAM,UPF0004 k59_716923_1 207954.MED92_02279 4.26e-05 44.7 COG2905@1|root,COG2905@2|Bacteria,1MZGY@1224|Proteobacteria,1S86K@1236|Gammaproteobacteria,1XJZ5@135619|Oceanospirillales 135619|Oceanospirillales T Domain in cystathionine beta-synthase and other proteins. - - - - - - - - - - - - CBS k59_716923_2 1202962.KB907156_gene3152 1.23e-54 173.0 COG0347@1|root,COG0347@2|Bacteria,1RI28@1224|Proteobacteria,1S62Z@1236|Gammaproteobacteria 1236|Gammaproteobacteria K Belongs to the P(II) protein family VV0993 - - - - - - - - - - - - k59_1276294_1 68219.JNXI01000003_gene4900 5.04e-58 183.0 2FATI@1|root,3430S@2|Bacteria,2IK0E@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - - k59_1107742_1 86106.I862_04760 3.96e-61 198.0 COG0630@1|root,COG0630@2|Bacteria,1R82Y@1224|Proteobacteria,2VGAD@28211|Alphaproteobacteria,47GSF@766|Rickettsiales 766|Rickettsiales NU Type II/IV secretion system protein virB11 - - ko:K03196 ko03070,ko05120,map03070,map05120 M00333,M00564 - - ko00000,ko00001,ko00002,ko02044 3.A.7 - - T2SSE k59_39125_1 1123399.AQVE01000008_gene1429 2.97e-81 251.0 COG1023@1|root,COG1023@2|Bacteria,1QU14@1224|Proteobacteria,1T1KM@1236|Gammaproteobacteria,463X7@72273|Thiotrichales 72273|Thiotrichales G 6-phosphogluconate dehydrogenase, C-terminal domain - - - - - - - - - - - - 6PGD,NAD_binding_2 k59_767820_1 1469557.JSWF01000032_gene3191 1.01e-64 220.0 COG1629@1|root,COG1629@2|Bacteria,4NF88@976|Bacteroidetes,1HY96@117743|Flavobacteriia 976|Bacteroidetes P receptor - - - - - - - - - - - - CarbopepD_reg_2,CarboxypepD_reg,OMP_b-brl_3 k59_1565784_1 47763.JNZA01000023_gene2827 1.22e-69 231.0 COG0205@1|root,COG3336@1|root,COG0205@2|Bacteria,COG3336@2|Bacteria,2GK6W@201174|Actinobacteria 201174|Actinobacteria G Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis pfkA GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 2.7.1.11,2.7.1.90 ko:K02351,ko:K07245,ko:K21071 ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130 - R00756,R00764,R02073,R03236,R04779 RC00002,RC00017 ko00000,ko00001,ko01000,ko02000 9.B.62.1 - - PFK k59_1673071_1 95619.PM1_0206680 1.51e-87 283.0 COG0653@1|root,COG0653@2|Bacteria,1MUJZ@1224|Proteobacteria,1RM9M@1236|Gammaproteobacteria 1236|Gammaproteobacteria U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane secA GO:0000166,GO:0002790,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006457,GO:0006605,GO:0006810,GO:0006886,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0009306,GO:0009987,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032940,GO:0032991,GO:0033036,GO:0033220,GO:0034613,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042802,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0046903,GO:0046907,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0061077,GO:0065002,GO:0070727,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680 - ko:K03070 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4 - - SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW k59_429881_1 243924.LT42_14105 1.75e-66 219.0 COG1752@1|root,COG1752@2|Bacteria,1PDQ2@1224|Proteobacteria,1RMWI@1236|Gammaproteobacteria 1236|Gammaproteobacteria S esterase of the alpha-beta hydrolase superfamily - - - ko:K07001 - - - - ko00000 - - - Patatin k59_993435_1 1278309.KB907103_gene1128 1.57e-91 280.0 COG0136@1|root,COG0136@2|Bacteria,1MUHG@1224|Proteobacteria,1RMN3@1236|Gammaproteobacteria,1XHYW@135619|Oceanospirillales 135619|Oceanospirillales E Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate asd - 1.2.1.11 ko:K00133 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00017,M00018,M00033,M00525,M00526,M00527 R02291 RC00684 ko00000,ko00001,ko00002,ko01000 - - - Semialdhyde_dh,Semialdhyde_dhC k59_1276308_2 1122137.AQXF01000005_gene1110 1.61e-89 266.0 COG0386@1|root,COG0386@2|Bacteria,1RD1R@1224|Proteobacteria,2TU17@28211|Alphaproteobacteria 28211|Alphaproteobacteria O Belongs to the glutathione peroxidase family bsaA - 1.11.1.9 ko:K00432 ko00480,ko00590,ko04918,map00480,map00590,map04918 - R00274,R07034,R07035 RC00011,RC00982 ko00000,ko00001,ko01000 - - - GSHPx k59_1276308_3 1122137.AQXF01000005_gene1111 9.4e-150 429.0 COG1902@1|root,COG1902@2|Bacteria,1MVIX@1224|Proteobacteria,2TT2F@28211|Alphaproteobacteria 28211|Alphaproteobacteria C NADH flavin oxidoreductase NADH oxidase - - 1.14.13.40 ko:K09461 ko00627,ko01120,map00627,map01120 - R03998,R03999 RC00244 ko00000,ko00001,ko01000 - - - FAD_binding_3,Oxidored_FMN k59_322338_1 290397.Adeh_1926 4.71e-118 354.0 COG0201@1|root,COG0201@2|Bacteria,1MVU7@1224|Proteobacteria,42MGM@68525|delta/epsilon subdivisions,2WIZ7@28221|Deltaproteobacteria,2YU46@29|Myxococcales 28221|Deltaproteobacteria U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently secY - - ko:K03076 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5 - - SecY k59_993444_1 176652.RIR1_IIV6 8.78e-34 135.0 4QAXQ@10239|Viruses,4QUSY@35237|dsDNA viruses no RNA stage 10239|Viruses S Ribonucleotide reductase, barrel domain - GO:0001959,GO:0001960,GO:0003674,GO:0003824,GO:0004748,GO:0005575,GO:0008150,GO:0008152,GO:0009966,GO:0009968,GO:0010646,GO:0010648,GO:0010803,GO:0010804,GO:0016491,GO:0016725,GO:0016728,GO:0018995,GO:0023051,GO:0023057,GO:0030430,GO:0033643,GO:0033646,GO:0043656,GO:0043657,GO:0044215,GO:0044216,GO:0044217,GO:0048519,GO:0048523,GO:0048583,GO:0048585,GO:0050789,GO:0050794,GO:0055114,GO:0060759,GO:0060761,GO:0061731,GO:0065007 - - - - - - - - - - - k59_39150_2 1158146.KB907126_gene1574 3.47e-15 72.8 COG0695@1|root,COG0695@2|Bacteria,1N0IY@1224|Proteobacteria,1SA4G@1236|Gammaproteobacteria,1X11H@135613|Chromatiales 135613|Chromatiales O Glutathione S-transferase, N-terminal domain - - - - - - - - - - - - GST_N_3 k59_540570_1 1182590.BN5_01897 1.34e-30 114.0 COG3088@1|root,COG3088@2|Bacteria,1MZZ5@1224|Proteobacteria,1S9DV@1236|Gammaproteobacteria,1YHK4@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria P subunit of a heme lyase ccmH GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008152,GO:0009897,GO:0009986,GO:0009987,GO:0015035,GO:0015036,GO:0016020,GO:0016043,GO:0016491,GO:0016667,GO:0017004,GO:0022607,GO:0031224,GO:0031226,GO:0031233,GO:0031237,GO:0034622,GO:0043933,GO:0044085,GO:0044425,GO:0044459,GO:0044464,GO:0055114,GO:0065003,GO:0071840,GO:0071944,GO:0098552,GO:0098567 - ko:K02200 - - - - ko00000 - - - CcmH k59_540570_2 1385517.N800_13405 7.48e-53 174.0 COG0526@1|root,COG0526@2|Bacteria,1RI3N@1224|Proteobacteria,1S5YV@1236|Gammaproteobacteria,1X5YS@135614|Xanthomonadales 135614|Xanthomonadales CO Thiol disulfide interchange protein dsbE - - ko:K02199 - - - - ko00000,ko03110 - - - Redoxin k59_1783223_2 159450.NH14_15905 1.52e-58 189.0 COG1024@1|root,COG1024@2|Bacteria,1MXHV@1224|Proteobacteria,2VHSP@28216|Betaproteobacteria,1K3GF@119060|Burkholderiaceae 28216|Betaproteobacteria I Belongs to the enoyl-CoA hydratase isomerase family abmC - - - - - - - - - - - ECH_1 k59_775913_1 316407.85676553 6.16e-119 347.0 28KGD@1|root,2ZA26@2|Bacteria,1NP1K@1224|Proteobacteria,1TGB4@1236|Gammaproteobacteria,3XQBH@561|Escherichia 1236|Gammaproteobacteria S Protein of unknown function (DUF2776) yhiM GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 - - - - - - - - - - DUF2776 k59_1682156_1 1122137.AQXF01000002_gene625 3.47e-149 432.0 COG0154@1|root,COG0154@2|Bacteria,1MUVQ@1224|Proteobacteria,2TRFY@28211|Alphaproteobacteria 28211|Alphaproteobacteria J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) gatA - 6.3.5.6,6.3.5.7 ko:K02433 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - Amidase k59_725527_1 1123257.AUFV01000005_gene1437 8.83e-154 444.0 COG0686@1|root,COG0686@2|Bacteria,1QTX1@1224|Proteobacteria,1T1JB@1236|Gammaproteobacteria,1X4JK@135614|Xanthomonadales 135614|Xanthomonadales E alanine dehydrogenase - - 1.4.1.1 ko:K00259 ko00250,ko00430,ko01100,map00250,map00430,map01100 - R00396 RC00008 ko00000,ko00001,ko01000 - - - AlaDh_PNT_C,AlaDh_PNT_N k59_725527_2 754476.Q7A_769 4.62e-33 120.0 2AGHX@1|root,316QI@2|Bacteria,1RI7I@1224|Proteobacteria,1S8W9@1236|Gammaproteobacteria,462RV@72273|Thiotrichales 72273|Thiotrichales - - - - - - - - - - - - - - - k59_1455053_1 977880.RALTA_A0763 6.45e-73 244.0 COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,2VHAN@28216|Betaproteobacteria,1KIEV@119060|Burkholderiaceae 28216|Betaproteobacteria V ABC transporter - - - ko:K06147 - - - - ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran k59_1175046_1 1415780.JPOG01000001_gene388 9.27e-39 143.0 COG2207@1|root,COG2207@2|Bacteria,1MX23@1224|Proteobacteria,1S2JB@1236|Gammaproteobacteria,1X9JC@135614|Xanthomonadales 135614|Xanthomonadales K Arabinose-binding domain of AraC transcription regulator, N-term - - - - - - - - - - - - Arabinose_bd,HTH_18 k59_1116313_1 644282.Deba_2871 5.69e-32 128.0 COG4745@1|root,COG4745@2|Bacteria 2|Bacteria O Dolichyl-phosphate-mannose-protein mannosyltransferase - - - - - - - - - - - - NHL,PMT_2 k59_330445_1 331869.BAL199_10607 1.8e-73 240.0 COG1123@1|root,COG4172@2|Bacteria,1MU09@1224|Proteobacteria,2TQP0@28211|Alphaproteobacteria,4BPA1@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria P Oligopeptide/dipeptide transporter, C-terminal region gsiA1 - - ko:K02031,ko:K02032 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - ABC_tran,oligo_HPY k59_895713_1 1323663.AROI01000051_gene3984 4.43e-113 335.0 COG1158@1|root,COG1158@2|Bacteria,1MUCF@1224|Proteobacteria,1RP95@1236|Gammaproteobacteria 1236|Gammaproteobacteria K Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template rho GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006353,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097659,GO:1901360,GO:1901362,GO:1901363,GO:1901576 - ko:K03628 ko03018,map03018 - - - ko00000,ko00001,ko03019,ko03021 - - - ATP-synt_ab,Rho_N,Rho_RNA_bind k59_214694_1 1469245.JFBG01000046_gene2238 1.93e-69 228.0 COG2414@1|root,COG2414@2|Bacteria,1MWBB@1224|Proteobacteria,1RSCT@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Aldehyde ferredoxin oxidoreductase ydhV GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016614,GO:0030151,GO:0033719,GO:0043167,GO:0043169,GO:0043546,GO:0044464,GO:0046872,GO:0046914,GO:0048037,GO:0050662,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0071944,GO:0097159,GO:1901363 1.2.7.5 ko:K03738 ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200 M00309 R08571 RC00242 ko00000,ko00001,ko00002,ko01000 - - - AFOR_C,AFOR_N k59_493819_1 56110.Oscil6304_2347 8.03e-48 177.0 COG0515@1|root,COG3899@1|root,COG4191@1|root,COG0515@2|Bacteria,COG3899@2|Bacteria,COG4191@2|Bacteria,1GBKM@1117|Cyanobacteria,1H7D9@1150|Oscillatoriales 1117|Cyanobacteria KLT Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - AAA_16,GAF,HATPase_c,HisKA,PAS_3,Pkinase k59_725547_1 1229909.NSED_07395 1.08e-108 332.0 COG0405@1|root,arCOG04053@2157|Archaea 2157|Archaea E gamma-glutamyltransferase ggt - 2.3.2.2,3.4.19.13 ko:K00681 ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100 - R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935 RC00064,RC00090,RC00096 ko00000,ko00001,ko01000,ko01002 - - - G_glu_transpept k59_103011_1 1125863.JAFN01000001_gene560 2.58e-13 69.3 COG2010@1|root,COG2010@2|Bacteria,1QYFZ@1224|Proteobacteria,43CC3@68525|delta/epsilon subdivisions,2WQTQ@28221|Deltaproteobacteria 28221|Deltaproteobacteria C Cytochrome c - - - - - - - - - - - - - k59_103011_2 1125863.JAFN01000001_gene561 2.87e-87 265.0 COG0437@1|root,COG0437@2|Bacteria,1MU1B@1224|Proteobacteria,43AKQ@68525|delta/epsilon subdivisions,2X60P@28221|Deltaproteobacteria 28221|Deltaproteobacteria C PFAM 4Fe-4S - - - ko:K00184 - - - - ko00000 5.A.3 - - Fer4_11,Fer4_4 k59_1285413_1 1248760.ANFZ01000019_gene1758 1.36e-24 108.0 COG3210@1|root,COG3210@2|Bacteria,1PZ6G@1224|Proteobacteria,2UCSJ@28211|Alphaproteobacteria,2K919@204457|Sphingomonadales 204457|Sphingomonadales U haemagglutination activity domain - - - - - - - - - - - - Haemagg_act k59_330470_1 1121448.DGI_3268 1.82e-47 166.0 COG2199@1|root,COG3706@2|Bacteria,1MXBG@1224|Proteobacteria,42NGW@68525|delta/epsilon subdivisions,2WKG6@28221|Deltaproteobacteria,2M8K8@213115|Desulfovibrionales 28221|Deltaproteobacteria T response regulator, receiver - - - - - - - - - - - - GGDEF,Response_reg k59_775952_1 1137281.D778_00209 1.35e-86 261.0 COG3000@1|root,COG3000@2|Bacteria,4NES7@976|Bacteroidetes,1HXQV@117743|Flavobacteriia 976|Bacteroidetes I Sterol desaturase - - - - - - - - - - - - FA_hydroxylase k59_1116334_2 1122137.AQXF01000004_gene1681 3.04e-64 206.0 COG0628@1|root,COG0628@2|Bacteria,1MW0B@1224|Proteobacteria,2TRD3@28211|Alphaproteobacteria 28211|Alphaproteobacteria S permease - - - ko:K03548 - - - - ko00000,ko02000 2.A.86.1 - - AI-2E_transport k59_1791686_1 572477.Alvin_0094 2.18e-18 80.1 COG0662@1|root,COG0662@2|Bacteria,1QUHG@1224|Proteobacteria,1T1Z6@1236|Gammaproteobacteria,1WZ1B@135613|Chromatiales 135613|Chromatiales G PFAM Cupin 2, conserved barrel - - - ko:K11312 - - - - ko00000 - - - Cupin_2 k59_775955_1 1207063.P24_06601 7.58e-42 140.0 COG0335@1|root,COG0335@2|Bacteria,1RH3A@1224|Proteobacteria,2U9DF@28211|Alphaproteobacteria,2JSS7@204441|Rhodospirillales 204441|Rhodospirillales J This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site rplS - - ko:K02884 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L19 k59_775955_2 1122137.AQXF01000007_gene3537 1.13e-62 197.0 COG0336@1|root,COG0336@2|Bacteria,1MUN1@1224|Proteobacteria,2TSIZ@28211|Alphaproteobacteria 28211|Alphaproteobacteria J Belongs to the RNA methyltransferase TrmD family trmD GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009019,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0016772,GO:0016779,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050518,GO:0070567,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.1.1.228 ko:K00554 - - R00597 RC00003,RC00334 ko00000,ko01000,ko03016 - - - tRNA_m1G_MT k59_47034_1 768671.ThimaDRAFT_3648 4.04e-42 150.0 COG1409@1|root,COG1409@2|Bacteria,1MUQJ@1224|Proteobacteria,1S12Q@1236|Gammaproteobacteria,1X063@135613|Chromatiales 135613|Chromatiales S Calcineurin-like phosphoesterase - - - - - - - - - - - - Metallophos k59_214719_1 582744.Msip34_2273 1.93e-15 79.7 COG3245@1|root,COG3245@2|Bacteria,1MZBZ@1224|Proteobacteria,2VMBB@28216|Betaproteobacteria,2KN03@206350|Nitrosomonadales 206350|Nitrosomonadales C PFAM Cytochrome C - - - - - - - - - - - - Cytochrome_CBB3 k59_1341682_2 911045.PSE_4389 1.61e-19 87.8 COG0546@1|root,COG0546@2|Bacteria,1N30E@1224|Proteobacteria 1224|Proteobacteria F Phosphoglycolate phosphatase - - 3.1.3.18 ko:K01091 ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130 - R01334 RC00017 ko00000,ko00001,ko01000 - - - HAD_2 k59_1341685_1 436308.Nmar_0471 2.04e-48 174.0 COG1948@1|root,arCOG02284@2157|Archaea,41T0R@651137|Thaumarchaeota 651137|Thaumarchaeota L Beta propeller domain - - - - - - - - - - - - Beta_propel k59_895737_1 1229909.NSED_00040 1.41e-97 293.0 COG0457@1|root,arCOG03032@2157|Archaea,41T0V@651137|Thaumarchaeota 651137|Thaumarchaeota S Tetratricopeptide repeat - - - - - - - - - - - - TPR_1 k59_895738_1 935567.JAES01000019_gene1043 8.94e-08 51.6 COG0450@1|root,COG0450@2|Bacteria,1MWPY@1224|Proteobacteria,1RN4S@1236|Gammaproteobacteria,1X35Z@135614|Xanthomonadales 135614|Xanthomonadales O Alkyl hydroperoxide reductase ahpC - 1.11.1.15 ko:K03386 ko04214,map04214 - - - ko00000,ko00001,ko01000,ko04147 - - - 1-cysPrx_C,AhpC-TSA k59_895738_2 99598.Cal7507_5874 3.31e-54 175.0 COG0783@1|root,COG0783@2|Bacteria,1G586@1117|Cyanobacteria,1HJQF@1161|Nostocales 1117|Cyanobacteria P Belongs to the Dps family dps - - ko:K04047 - - - - ko00000,ko03036 - - - Ferritin k59_895738_3 246196.MSMEI_0153 9.65e-05 43.9 COG0583@1|root,COG0583@2|Bacteria,2H0AE@201174|Actinobacteria,234NB@1762|Mycobacteriaceae 201174|Actinobacteria K Bacterial regulatory helix-turn-helix protein, lysR family oxyS - - - - - - - - - - - HTH_1,LysR_substrate k59_1116345_1 196490.AUEZ01000001_gene7318 4.11e-109 337.0 COG3119@1|root,COG3119@2|Bacteria,1MV92@1224|Proteobacteria,2TTXG@28211|Alphaproteobacteria,3JVJZ@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria P Sulfatase - - 3.1.6.1 ko:K01130 ko00140,ko00600,map00140,map00600 - R03980,R04856 RC00128,RC00231 ko00000,ko00001,ko01000 - - - Sulfatase k59_1002259_1 994479.GL877884_gene7621 1.26e-06 55.1 COG0741@1|root,COG0741@2|Bacteria,2I2XS@201174|Actinobacteria,4EF9Z@85010|Pseudonocardiales 201174|Actinobacteria M Transglycosylase SLT domain - - - - - - - - - - - - Peptidase_M23,SLT_2 k59_664635_1 492774.JQMB01000007_gene3952 5.18e-36 127.0 COG3791@1|root,COG3791@2|Bacteria,1N031@1224|Proteobacteria,2UC7G@28211|Alphaproteobacteria,4BFAS@82115|Rhizobiaceae 28211|Alphaproteobacteria S Glutathione-dependent formaldehyde-activating enzyme - - - - - - - - - - - - GFA k59_103058_1 159087.Daro_4059 2.23e-85 267.0 COG4402@1|root,COG4402@2|Bacteria,1MVMM@1224|Proteobacteria,2VZKJ@28216|Betaproteobacteria 28216|Betaproteobacteria S Uncharacterized protein conserved in bacteria (DUF2330) - - - - - - - - - - - - DUF2330 k59_1341697_1 436308.Nmar_0332 2.45e-118 351.0 COG0053@1|root,arCOG01474@2157|Archaea,arCOG01475@2157|Archaea,41SXN@651137|Thaumarchaeota 651137|Thaumarchaeota P cation diffusion facilitator family transporter - - - - - - - - - - - - Cation_efflux,ZT_dimer k59_1341697_2 1229909.NSED_01600 2.26e-06 50.4 arCOG08778@1|root,arCOG08778@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_1739470_1 702113.PP1Y_AT990 6.12e-82 248.0 COG1346@1|root,COG1346@2|Bacteria,1MV81@1224|Proteobacteria,2TSP3@28211|Alphaproteobacteria,2K3UZ@204457|Sphingomonadales 204457|Sphingomonadales M LrgB-like family - - - - - - - - - - - - LrgB k59_1574201_1 158500.BV97_02768 1.17e-107 314.0 COG0217@1|root,COG0217@2|Bacteria,1MW3X@1224|Proteobacteria,2TRSK@28211|Alphaproteobacteria,2K0KW@204457|Sphingomonadales 204457|Sphingomonadales K transcriptional regulatory protein - - - - - - - - - - - - Transcrip_reg k59_1574201_2 1346791.M529_13325 1.25e-23 93.2 COG1247@1|root,COG1247@2|Bacteria,1RDHN@1224|Proteobacteria,2U98I@28211|Alphaproteobacteria,2K490@204457|Sphingomonadales 204457|Sphingomonadales M Acetyltransferase (GNAT) domain - - 2.3.1.183 ko:K03823 ko00440,ko01130,map00440,map01130 - R08871,R08938 RC00004,RC00064 ko00000,ko00001,ko01000 - - - Acetyltransf_4 k59_330488_1 1122137.AQXF01000001_gene2950 4.98e-83 253.0 COG1024@1|root,COG1024@2|Bacteria,1PJ4R@1224|Proteobacteria,2TSSU@28211|Alphaproteobacteria 28211|Alphaproteobacteria I Belongs to the enoyl-CoA hydratase isomerase family - - 4.2.1.17 ko:K01692 ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212 M00032,M00087 R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093 RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 - - - ECH_1 k59_725604_1 555500.I215_02533 5.45e-07 50.8 COG0535@1|root,COG0535@2|Bacteria,4NEGK@976|Bacteroidetes,1HYIP@117743|Flavobacteriia 976|Bacteroidetes S radical SAM domain protein - - - - - - - - - - - - - k59_725604_2 1443665.JACA01000022_gene5153 1.58e-16 77.8 COG2873@1|root,COG2873@2|Bacteria,4NE27@976|Bacteroidetes,1HXJC@117743|Flavobacteriia,2YGQY@290174|Aquimarina 976|Bacteroidetes E DegT/DnrJ/EryC1/StrS aminotransferase family metY - 2.5.1.49 ko:K01740 ko00270,ko01100,map00270,map01100 - R01287,R04859 RC00020,RC02821,RC02848 ko00000,ko00001,ko01000 - - - Cys_Met_Meta_PP k59_1285468_1 36331.EPrPI00000015596 1.74e-17 88.6 COG0657@1|root,KOG1515@2759|Eukaryota 2759|Eukaryota I carboxylic ester hydrolase activity - - - - - - - - - - - - Abhydrolase_3,Peptidase_S9 k59_946548_1 583355.Caka_2268 7.86e-38 130.0 COG0848@1|root,COG0848@2|Bacteria,46VV0@74201|Verrucomicrobia 74201|Verrucomicrobia U Biopolymer transport protein ExbD/TolR - - - ko:K03559 - - - - ko00000,ko02000 1.A.30.2.1 - - ExbD k59_1063551_1 589924.Ferp_0473 2.09e-22 97.4 COG1525@1|root,arCOG03192@2157|Archaea,2XTIT@28890|Euryarchaeota,246V2@183980|Archaeoglobi 183980|Archaeoglobi L SMART nuclease (SNase domain protein) - - 3.1.31.1 ko:K01174 - - - - ko00000,ko01000 - - - SNase k59_1627034_1 269798.CHU_1967 1.83e-107 318.0 COG1116@1|root,COG1116@2|Bacteria,4PKJ3@976|Bacteroidetes,47XCV@768503|Cytophagia 976|Bacteroidetes P ATPases associated with a variety of cellular activities - - - ko:K15578 ko00910,ko02010,map00910,map02010 M00438 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.16.1 - - ABC_tran k59_47079_1 1056820.KB900696_gene3975 1.42e-109 321.0 28J4W@1|root,2Z90S@2|Bacteria,1R68N@1224|Proteobacteria,1RRQ2@1236|Gammaproteobacteria,2PMZV@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_1791731_1 933262.AXAM01000022_gene3224 1.64e-44 150.0 COG0757@1|root,COG0757@2|Bacteria,1RDDT@1224|Proteobacteria,42QU1@68525|delta/epsilon subdivisions,2WP6E@28221|Deltaproteobacteria,2MK5F@213118|Desulfobacterales 28221|Deltaproteobacteria E Catalyzes a trans-dehydration via an enolate intermediate aroQ - 4.2.1.10 ko:K03786 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R03084 RC00848 ko00000,ko00001,ko00002,ko01000 - - - DHquinase_II k59_1791731_2 926566.Terro_1739 6.32e-26 110.0 COG0006@1|root,COG0006@2|Bacteria,3Y3IN@57723|Acidobacteria,2JI8R@204432|Acidobacteriia 204432|Acidobacteriia E Creatinase/Prolidase N-terminal domain - - 3.4.11.9 ko:K01262 - - - - ko00000,ko01000,ko01002 - - - Creatinase_N,Peptidase_M24 k59_47096_2 436308.Nmar_1777 1.12e-28 109.0 COG0846@1|root,arCOG04248@2157|Archaea,41SWP@651137|Thaumarchaeota 651137|Thaumarchaeota K NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form. Deacetylates the N-terminal lysine residue of Alba, the major archaeal chromatin protein and that, in turn, increases Alba's DNA binding affinity, thereby repressing transcription cobB - - ko:K12410 - - - - ko00000,ko01000 - - - SIR2 k59_1341733_1 13690.CP98_00135 3.78e-79 256.0 COG0376@1|root,COG0376@2|Bacteria,1MUBF@1224|Proteobacteria,2TQJ7@28211|Alphaproteobacteria,2K0B7@204457|Sphingomonadales 204457|Sphingomonadales P Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity katG - 1.11.1.21 ko:K03782 ko00360,ko00380,ko00940,ko00983,ko01100,ko01110,map00360,map00380,map00940,map00983,map01100,map01110 - R00602,R00698,R02596,R02670,R03919,R04007,R07443,R11906 RC00034,RC00213,RC00767,RC02141 ko00000,ko00001,ko01000 - - - peroxidase k59_835322_1 876269.ARWA01000001_gene1486 7.85e-45 151.0 COG2080@1|root,COG2080@2|Bacteria,1RD8C@1224|Proteobacteria,2U5BM@28211|Alphaproteobacteria,3NCGW@45404|Beijerinckiaceae 28211|Alphaproteobacteria C [2Fe-2S] binding domain coxS - 1.2.5.3 ko:K03518 - - R11168 RC02800 ko00000,ko01000 - - - Fer2,Fer2_2 k59_103105_1 1157490.EL26_14255 1.58e-17 87.0 COG1233@1|root,COG1233@2|Bacteria,1UU71@1239|Firmicutes,4HA25@91061|Bacilli 91061|Bacilli Q Phytoene dehydrogenase - - 5.2.1.13 ko:K09835 ko00906,ko01100,ko01110,map00906,map01100,map01110 M00097 R07512 RC01960 ko00000,ko00001,ko00002,ko01000 - - - Amino_oxidase k59_387339_1 706587.Desti_3707 1.7e-93 288.0 COG0056@1|root,COG0056@2|Bacteria,1MUG7@1224|Proteobacteria,42MVX@68525|delta/epsilon subdivisions,2WIK7@28221|Deltaproteobacteria,2MRD2@213462|Syntrophobacterales 28221|Deltaproteobacteria F Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit atpA - 3.6.3.14 ko:K02111 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - - ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N k59_103130_1 1229909.NSED_06030 4.58e-100 297.0 COG0484@1|root,COG1141@1|root,arCOG00349@2157|Archaea,arCOG02846@2157|Archaea,41ST0@651137|Thaumarchaeota 651137|Thaumarchaeota CO DnaJ-class molecular chaperone with C-terminal Zn finger domain - - - - - - - - - - - - DnaJ,Fer4_13 k59_103130_2 436308.Nmar_1025 1.01e-56 180.0 COG0537@1|root,arCOG00419@2157|Archaea,41SNI@651137|Thaumarchaeota 651137|Thaumarchaeota F HIT domain - - - ko:K02503 - - - - ko00000,ko04147 - - - HIT k59_664700_1 1123355.JHYO01000013_gene1073 4.9e-33 128.0 COG0471@1|root,COG0471@2|Bacteria,1MU0K@1224|Proteobacteria,2TSFS@28211|Alphaproteobacteria 28211|Alphaproteobacteria P COG0471 Di- and tricarboxylate transporters - - - - - - - - - - - - CitMHS,TrkA_C k59_1002323_1 84531.JMTZ01000149_gene1651 5.63e-29 122.0 COG1361@1|root,COG1361@2|Bacteria,1QCP2@1224|Proteobacteria,1T8ES@1236|Gammaproteobacteria,1XAJ3@135614|Xanthomonadales 135614|Xanthomonadales M Conserved repeat domain - - - - - - - - - - - - - k59_272817_1 999541.bgla_2g25600 5.26e-73 246.0 COG0439@1|root,COG1984@1|root,COG2049@1|root,COG0439@2|Bacteria,COG1984@2|Bacteria,COG2049@2|Bacteria,1MU4H@1224|Proteobacteria,2WGI2@28216|Betaproteobacteria,1K3CB@119060|Burkholderiaceae 28216|Betaproteobacteria EI urea carboxylase uca - 6.3.4.6 ko:K01941 ko00220,ko00791,ko01100,map00220,map00791,map01100 - R00774 RC00378 ko00000,ko00001,ko01000 - - - Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2,CT_A_B,CT_C_D k59_438277_1 1122134.KB893651_gene1991 4.99e-56 185.0 COG2945@1|root,COG2945@2|Bacteria,1MUDY@1224|Proteobacteria,1S4MG@1236|Gammaproteobacteria,1XS83@135619|Oceanospirillales 135619|Oceanospirillales S Serine aminopeptidase, S33 - - - ko:K07018 - - - - ko00000 - - - Hydrolase_4 k59_1404364_1 1045856.EcWSU1_00431 4.91e-20 87.0 COG1172@1|root,COG1172@2|Bacteria,1MW9Z@1224|Proteobacteria,1RQ77@1236|Gammaproteobacteria,3X1DM@547|Enterobacter 1236|Gammaproteobacteria P Belongs to the binding-protein-dependent transport system permease family yjfF GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 - ko:K02057,ko:K10440,ko:K17209 ko02010,map02010 M00212,M00221,M00592 - - ko00000,ko00001,ko00002,ko02000 3.A.1.2,3.A.1.2.1,3.A.1.2.13,3.A.1.2.19,3.A.1.2.21 - iECW_1372.ECW_m4592,iEKO11_1354.EKO11_4080,iWFL_1372.ECW_m4592 BPD_transp_2 k59_1404364_2 511145.b4230 2.08e-140 403.0 COG1172@1|root,COG1172@2|Bacteria,1MUM6@1224|Proteobacteria,1RRCX@1236|Gammaproteobacteria,3XMG1@561|Escherichia 1236|Gammaproteobacteria G Belongs to the binding-protein-dependent transport system permease family ytfT GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 - ko:K02057,ko:K10440 ko02010,map02010 M00212,M00221 - - ko00000,ko00001,ko00002,ko02000 3.A.1.2,3.A.1.2.1,3.A.1.2.13,3.A.1.2.19 - iAPECO1_1312.APECO1_2162,iECH74115_1262.ECH74115_5749,iECOK1_1307.ECOK1_4745,iECSF_1327.ECSF_4119,iLF82_1304.LF82_3716,iUTI89_1310.UTI89_C4834,ic_1306.c5327 BPD_transp_2 k59_1404370_1 596151.DesfrDRAFT_1980 8.71e-15 78.6 COG1088@1|root,COG1088@2|Bacteria,1MU5E@1224|Proteobacteria,42MFN@68525|delta/epsilon subdivisions,2WIJE@28221|Deltaproteobacteria,2M8IN@213115|Desulfovibrionales 28221|Deltaproteobacteria M Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily rfbB - 4.2.1.46 ko:K01710 ko00521,ko00523,ko00525,ko01055,ko01130,map00521,map00523,map00525,map01055,map01130 M00793 R06513 RC00402 ko00000,ko00001,ko00002,ko01000 - - - GDP_Man_Dehyd k59_272824_2 324602.Caur_1802 6.47e-32 123.0 COG0520@1|root,COG0520@2|Bacteria,2G5W7@200795|Chloroflexi,375CE@32061|Chloroflexia 32061|Chloroflexia E TIGRFAM cysteine desulfurase family protein - - - - - - - - - - - - Aminotran_5 k59_47151_1 945713.IALB_2618 1.27e-71 228.0 COG3033@1|root,COG3033@2|Bacteria 2|Bacteria E tryptophanase activity tnaA - 4.1.99.1 ko:K01667 ko00380,map00380 - R00673 RC00209,RC00355 ko00000,ko00001,ko01000 - - - Beta_elim_lyase k59_1002335_1 1211112.ALJC01000073_gene3212 5.49e-73 229.0 COG1071@1|root,COG1071@2|Bacteria,1MU5R@1224|Proteobacteria,1RWHU@1236|Gammaproteobacteria 1236|Gammaproteobacteria C dehydrogenase e1 component acoA - - ko:K21416 - - - - ko00000,ko01000 - - - E1_dh k59_438287_1 1041930.Mtc_2376 8.46e-78 249.0 COG0459@1|root,arCOG01257@2157|Archaea,2XUDQ@28890|Euryarchaeota,2N9DC@224756|Methanomicrobia 224756|Methanomicrobia O PFAM chaperonin Cpn60 TCP-1 - - - ko:K22447 - - - - ko00000,ko03110 - - - Cpn60_TCP1 k59_836616_3 768671.ThimaDRAFT_4354 2.38e-26 107.0 COG0137@1|root,COG1948@1|root,COG0137@2|Bacteria,COG1948@2|Bacteria,1MV0Y@1224|Proteobacteria,1RMEC@1236|Gammaproteobacteria,1WXPT@135613|Chromatiales 135613|Chromatiales E Belongs to the argininosuccinate synthase family. Type 1 subfamily argG - 6.3.4.5 ko:K01940 ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418 M00029,M00844,M00845 R01954 RC00380,RC00629 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Arginosuc_synth k59_947903_1 702113.PP1Y_AT34950 4.74e-149 428.0 COG1752@1|root,COG1752@2|Bacteria,1MVHW@1224|Proteobacteria,2TS4V@28211|Alphaproteobacteria,2K15U@204457|Sphingomonadales 204457|Sphingomonadales S esterase of the alpha-beta hydrolase superfamily - - - ko:K07001 - - - - ko00000 - - - DUF3734,Patatin k59_1740625_1 1270193.JARP01000001_gene3041 2.69e-30 119.0 COG2972@1|root,COG2972@2|Bacteria,4NHY2@976|Bacteroidetes,1I7QM@117743|Flavobacteriia,2NUVI@237|Flavobacterium 976|Bacteroidetes T Histidine kinase - - - - - - - - - - - - His_kinase k59_836618_1 235985.BBPN01000006_gene3651 3.16e-16 86.3 COG0667@1|root,COG0667@2|Bacteria,2GMNA@201174|Actinobacteria,2NFPD@228398|Streptacidiphilus 201174|Actinobacteria C Aldo/keto reductase family - - - - - - - - - - - - Aldo_ket_red k59_1064813_1 2754.EH55_03090 6.44e-22 98.2 COG0772@1|root,COG0772@2|Bacteria,3T9VR@508458|Synergistetes 508458|Synergistetes D Belongs to the SEDS family rodA - - ko:K05837 - - - - ko00000,ko03036 - - - FTSW_RODA_SPOVE k59_1286822_1 1522072.IL54_1770 5.7e-114 340.0 COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,2TR8H@28211|Alphaproteobacteria,2JZWH@204457|Sphingomonadales 204457|Sphingomonadales C COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes - - 1.8.1.4 ko:K00382 ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00036,M00307,M00532 R00209,R01221,R01698,R03815,R07618,R08549 RC00004,RC00022,RC00583,RC02742,RC02833,RC02834 br01601,ko00000,ko00001,ko00002,ko01000,ko04147 - - - Pyr_redox_2,Pyr_redox_dim k59_215977_1 1122137.AQXF01000009_gene8 7.1e-137 390.0 COG0081@1|root,COG0081@2|Bacteria,1MUE6@1224|Proteobacteria,2TRXP@28211|Alphaproteobacteria 28211|Alphaproteobacteria J Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release rplA GO:0000470,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022625,GO:0022626,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02863 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L1 k59_215977_2 1479239.JQMU01000001_gene1010 1.09e-24 96.3 COG0080@1|root,COG0080@2|Bacteria,1RA2M@1224|Proteobacteria,2U760@28211|Alphaproteobacteria,2K3Z9@204457|Sphingomonadales 204457|Sphingomonadales J Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors rplK - - ko:K02867 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L11,Ribosomal_L11_N k59_1518058_1 305900.GV64_03470 5.91e-55 186.0 COG0810@1|root,COG0810@2|Bacteria,1MUMT@1224|Proteobacteria,1S3A6@1236|Gammaproteobacteria,1XJV0@135619|Oceanospirillales 135619|Oceanospirillales M Periplasmic protein TonB, links inner and outer membranes tonB - - ko:K03832 - - - - ko00000,ko02000 2.C.1.1 - - TonB_C k59_1518058_2 1415778.JQMM01000001_gene642 4.4e-32 119.0 COG1678@1|root,COG1678@2|Bacteria,1RCXM@1224|Proteobacteria,1S3YV@1236|Gammaproteobacteria,1J62V@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria K Belongs to the UPF0301 (AlgH) family yqgE GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - ko:K07735 - - - - ko00000,ko03000 - - - DUF179 k59_273994_1 1280949.HAD_07565 1.48e-25 103.0 COG3803@1|root,COG3803@2|Bacteria,1RHYI@1224|Proteobacteria,2U7AN@28211|Alphaproteobacteria,43XSR@69657|Hyphomonadaceae 28211|Alphaproteobacteria S Bacterial protein of unknown function (DUF924) - - - - - - - - - - - - DUF924 k59_665987_1 335283.Neut_1152 2.81e-59 196.0 COG0133@1|root,COG0133@2|Bacteria,1MUS8@1224|Proteobacteria,2VHV3@28216|Betaproteobacteria,372AR@32003|Nitrosomonadales 28216|Betaproteobacteria E The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine trpB GO:0000162,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0042802,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.2.1.20 ko:K01696 ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230 M00023 R00674,R02340,R02722 RC00209,RC00210,RC00700,RC00701,RC02868 ko00000,ko00001,ko00002,ko01000 - - - PALP k59_897135_1 1095769.CAHF01000006_gene1954 3.6e-79 249.0 COG0312@1|root,COG0312@2|Bacteria,1NSH6@1224|Proteobacteria,2VJRT@28216|Betaproteobacteria,475XU@75682|Oxalobacteraceae 28216|Betaproteobacteria S Putative modulator of DNA gyrase - - - - - - - - - - - - PmbA_TldD k59_1286846_1 314287.GB2207_01662 1.33e-72 242.0 COG0793@1|root,COG0793@2|Bacteria,1MU39@1224|Proteobacteria,1RMSR@1236|Gammaproteobacteria,1J57P@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Belongs to the peptidase S41A family prc GO:0003674,GO:0003824,GO:0004175,GO:0005575,GO:0005623,GO:0005886,GO:0006508,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0016020,GO:0016787,GO:0019538,GO:0023052,GO:0030163,GO:0030288,GO:0030313,GO:0031975,GO:0042221,GO:0042597,GO:0043170,GO:0044238,GO:0044464,GO:0046677,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901565,GO:1901575 3.4.21.102 ko:K03797 - - - - ko00000,ko01000,ko01002 - - - BAGE,DUF3340,PDZ,Peptidase_S41 k59_947937_1 555793.WSK_1370 5.93e-101 306.0 COG2148@1|root,COG2148@2|Bacteria,1MV6W@1224|Proteobacteria,2TRZA@28211|Alphaproteobacteria,2K0H7@204457|Sphingomonadales 204457|Sphingomonadales M sugar transferase - - - - - - - - - - - - Bac_transf,CoA_binding_3 k59_331698_1 439235.Dalk_4243 1.36e-16 73.6 COG0234@1|root,COG0234@2|Bacteria,1MZ2X@1224|Proteobacteria,42U7E@68525|delta/epsilon subdivisions,2WPZP@28221|Deltaproteobacteria,2MKH2@213118|Desulfobacterales 28221|Deltaproteobacteria O Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter groS GO:0003674,GO:0005488,GO:0005515,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008150,GO:0009987,GO:0010033,GO:0035966,GO:0042221,GO:0043167,GO:0043169,GO:0046872,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0061077 - ko:K04078 - - - - ko00000,ko03029,ko03110 - - - Cpn10 k59_331698_2 382464.ABSI01000006_gene754 7.57e-49 169.0 COG0459@1|root,COG0459@2|Bacteria,46S9U@74201|Verrucomicrobia,2ITQ1@203494|Verrucomicrobiae 203494|Verrucomicrobiae O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions groL - - ko:K04077 ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 - - - Cpn60_TCP1 k59_897138_1 1484460.JSWG01000001_gene2238 1.29e-96 309.0 COG0841@1|root,COG0841@2|Bacteria,4NDZG@976|Bacteroidetes,1HX2H@117743|Flavobacteriia 976|Bacteroidetes V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_165610_1 102129.Lepto7375DRAFT_2461 3.53e-67 227.0 COG1413@1|root,COG1413@2|Bacteria,1G1H5@1117|Cyanobacteria,1HGMN@1150|Oscillatoriales 1117|Cyanobacteria C Domain of unknown function (DUF4132) - - - - - - - - - - - - DUF4132 k59_954679_1 1298867.AUES01000025_gene3072 2.55e-36 131.0 COG0111@1|root,COG0111@2|Bacteria,1MW0R@1224|Proteobacteria,2TWC9@28211|Alphaproteobacteria,3JVP3@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria EH D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain - - 1.1.1.399,1.1.1.95 ko:K00058 ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230 M00020 R01513 RC00031 ko00000,ko00001,ko00002,ko01000,ko04147 - - - 2-Hacid_dh,2-Hacid_dh_C k59_954679_2 349521.HCH_01668 9.12e-09 56.6 COG1024@1|root,COG1024@2|Bacteria,1PJ4R@1224|Proteobacteria,1RPGI@1236|Gammaproteobacteria,1XJ0U@135619|Oceanospirillales 135619|Oceanospirillales I enoyl-CoA hydratase - - 4.2.1.17 ko:K01692 ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212 M00032,M00087 R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093 RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 - - - ECH_1 k59_1690389_1 436308.Nmar_1525 2.07e-152 434.0 COG0042@1|root,arCOG00604@2157|Archaea 2157|Archaea J Dihydrouridine synthase (Dus) dusA1 - - - - - - - - - - - Dus k59_1799722_1 1005048.CFU_3655 1.01e-71 238.0 COG3590@1|root,COG3590@2|Bacteria,1MVNQ@1224|Proteobacteria,2VMJF@28216|Betaproteobacteria,473TW@75682|Oxalobacteraceae 28216|Betaproteobacteria O Peptidase family M13 - - - ko:K07386 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M13,Peptidase_M13_N k59_733824_1 1121937.AUHJ01000036_gene2808 4.77e-60 193.0 2CIH3@1|root,32KXU@2|Bacteria,1RJBB@1224|Proteobacteria,1S7QK@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_1124419_1 709797.CSIRO_4158 3.03e-28 119.0 COG0457@1|root,COG3914@1|root,COG0457@2|Bacteria,COG3914@2|Bacteria,1MVMG@1224|Proteobacteria,2TRVB@28211|Alphaproteobacteria,3JR8N@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria O Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - - - - - - - - - - Glyco_transf_41,Methyltransf_23,TPR_1,TPR_11,TPR_16,TPR_2,TPR_8 k59_1690399_1 203122.Sde_0398 2e-60 206.0 COG0188@1|root,COG0188@2|Bacteria,1MURI@1224|Proteobacteria,1RMTC@1236|Gammaproteobacteria,464Q5@72275|Alteromonadaceae 1236|Gammaproteobacteria L Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule parC GO:0000819,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006265,GO:0006276,GO:0006725,GO:0006807,GO:0006996,GO:0007049,GO:0007059,GO:0007062,GO:0008150,GO:0008152,GO:0009330,GO:0009987,GO:0016020,GO:0016043,GO:0019897,GO:0019898,GO:0022402,GO:0030541,GO:0032991,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0046483,GO:0051276,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:0098813,GO:1901360,GO:1901363 - ko:K02621 - - - - ko00000,ko01000,ko02048,ko03032,ko03036 - - - DNA_gyraseA_C,DNA_topoisoIV k59_55329_1 1549858.MC45_07335 5.26e-74 243.0 COG1472@1|root,COG1472@2|Bacteria,1MVIV@1224|Proteobacteria,2TS28@28211|Alphaproteobacteria,2JZVY@204457|Sphingomonadales 204457|Sphingomonadales G Belongs to the glycosyl hydrolase 3 family - - 3.2.1.21 ko:K05349 ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110 - R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040 RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248 ko00000,ko00001,ko01000 - GH3 - Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C k59_1238975_1 983544.Lacal_2842 3.67e-95 300.0 COG0022@1|root,COG1071@1|root,COG0022@2|Bacteria,COG1071@2|Bacteria,4NE4A@976|Bacteroidetes,1HYUM@117743|Flavobacteriia 976|Bacteroidetes C Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type pdhB - 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 - - - E1_dh,Transket_pyr,Transketolase_C k59_338577_1 436229.JOEH01000002_gene3425 4.64e-34 127.0 COG1071@1|root,COG1071@2|Bacteria,2GK3W@201174|Actinobacteria,2NNCT@228398|Streptacidiphilus 201174|Actinobacteria C Dehydrogenase E1 component acoA - 1.2.4.1 ko:K00161,ko:K21416 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230 M00307 R00014,R00209,R01699,R03270 RC00004,RC00027,RC00627,RC02742,RC02744,RC02882 br01601,ko00000,ko00001,ko00002,ko01000 - - - E1_dh k59_338577_2 285514.JNWO01000001_gene4733 2.84e-119 352.0 COG0006@1|root,COG0006@2|Bacteria,2H45Q@201174|Actinobacteria 201174|Actinobacteria E Metallopeptidase family M24 - - - - - - - - - - - - Creatinase_N,Peptidase_M24 k59_1524860_1 391625.PPSIR1_31213 8.17e-130 388.0 COG1132@1|root,COG1132@2|Bacteria,1MXC2@1224|Proteobacteria,42PQK@68525|delta/epsilon subdivisions,2WJCT@28221|Deltaproteobacteria,2YUHK@29|Myxococcales 28221|Deltaproteobacteria P ABC transporter - - - ko:K06147,ko:K06148 - - - - ko00000,ko02000 3.A.1,3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran k59_903862_1 436308.Nmar_1508 6.67e-92 270.0 COG0184@1|root,arCOG04185@2157|Archaea,41SKP@651137|Thaumarchaeota 651137|Thaumarchaeota J ribosomal protein rps15 - - ko:K02956 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S13_N,Ribosomal_S15 k59_784047_1 479431.Namu_4107 8.63e-67 222.0 COG0508@1|root,COG0508@2|Bacteria,2GMUV@201174|Actinobacteria,4ERCG@85013|Frankiales 201174|Actinobacteria C TIGRFAM 2-oxoglutarate dehydrogenase, E2 component - - 2.3.1.168,2.3.1.61 ko:K00658,ko:K09699 ko00020,ko00280,ko00310,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00280,map00310,map00640,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00032,M00036 R02570,R02571,R02662,R03174,R04097,R08549,R10998 RC00004,RC02727,RC02833,RC02870 br01601,ko00000,ko00001,ko00002,ko01000 - - - 2-oxoacid_dh,Biotin_lipoyl,E3_binding k59_1071537_1 1232683.ADIMK_1818 6.82e-91 281.0 COG2223@1|root,COG2223@2|Bacteria,1MU27@1224|Proteobacteria,1RP5H@1236|Gammaproteobacteria,4651E@72275|Alteromonadaceae 1236|Gammaproteobacteria P COG2223 Nitrate nitrite transporter - - - ko:K02575 ko00910,map00910 M00615 - - ko00000,ko00001,ko00002,ko02000 2.A.1.8 - - MFS_1 k59_733851_1 1396418.BATQ01000134_gene4112 9.55e-25 107.0 COG1129@1|root,COG1129@2|Bacteria,46SG6@74201|Verrucomicrobia,2IV5X@203494|Verrucomicrobiae 203494|Verrucomicrobiae G ATPases associated with a variety of cellular activities - - - - - - - - - - - - ABC_tran k59_733851_2 476272.RUMHYD_03417 2.74e-20 98.6 COG1172@1|root,COG1172@2|Bacteria,1TP72@1239|Firmicutes,249FA@186801|Clostridia,3Y07K@572511|Blautia 186801|Clostridia P Psort location CytoplasmicMembrane, score 10.00 - - - - - - - - - - - - BPD_transp_2 k59_903869_1 485913.Krac_7501 1.64e-31 116.0 COG0316@1|root,COG0316@2|Bacteria,2G705@200795|Chloroflexi 200795|Chloroflexi S Belongs to the HesB IscA family - - - ko:K13628 - - - - ko00000,ko03016 - - - Fe-S_biosyn k59_1239006_1 686578.AFFX01000004_gene3708 7.49e-65 212.0 28H52@1|root,2Z7HQ@2|Bacteria,1MXTF@1224|Proteobacteria,1RN8H@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Protein of unknown function (DUF1329) - - - - - - - - - - - - DUF1329 k59_280915_1 95619.PM1_0225950 6.88e-47 160.0 COG0714@1|root,COG0714@2|Bacteria,1MUFN@1224|Proteobacteria,1RP45@1236|Gammaproteobacteria 1236|Gammaproteobacteria S associated with various cellular activities moxR - - ko:K03924 - - - - ko00000,ko01000 - - - AAA_3 k59_280915_2 521719.ATXQ01000001_gene628 5.96e-17 79.7 COG0312@1|root,COG0312@2|Bacteria,1MUVW@1224|Proteobacteria,1RPJF@1236|Gammaproteobacteria,1YF5X@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria S Putative modulator of DNA gyrase pmbA GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0019538,GO:0043170,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:1901564 - ko:K03592 - - - - ko00000,ko01002 - - - PmbA_TldD k59_672699_1 1499686.BN1079_00592 4.24e-23 103.0 COG0446@1|root,COG1902@1|root,COG0446@2|Bacteria,COG1902@2|Bacteria,1MVE0@1224|Proteobacteria,1RNM8@1236|Gammaproteobacteria 1236|Gammaproteobacteria C COG1902 NADH flavin oxidoreductases, Old Yellow Enzyme family - - 1.5.8.1,1.5.8.2 ko:K00317 ko00680,ko01120,ko01200,map00680,map01120,map01200 - R01588,R02511 RC00185,RC00556,RC00557,RC00732 ko00000,ko00001,ko01000 - - - Oxidored_FMN,Pyr_redox_2 k59_954715_1 1458357.BG58_36050 2.39e-24 107.0 COG2114@1|root,COG3899@1|root,COG2114@2|Bacteria,COG3899@2|Bacteria,1MUDT@1224|Proteobacteria,2VKH1@28216|Betaproteobacteria,1JZT2@119060|Burkholderiaceae 28216|Betaproteobacteria T adenylyl cyclase class-3 4 guanylyl cyclase - - - - - - - - - - - - AAA_16,BTAD,Guanylate_cyc,Pkinase,SAM_1 k59_165663_1 391603.FBALC1_02662 1.42e-106 318.0 COG2873@1|root,COG2873@2|Bacteria,4NE27@976|Bacteroidetes,1HXJC@117743|Flavobacteriia 976|Bacteroidetes E Catalyzes the formation of L-homocysteine from O- succinyl-L-homoserine (OSHS) and hydrogen sulfide metY - 2.5.1.49 ko:K01740 ko00270,ko01100,map00270,map01100 - R01287,R04859 RC00020,RC02821,RC02848 ko00000,ko00001,ko01000 - - - Cys_Met_Meta_PP k59_165681_1 1392489.JPOL01000002_gene2268 2.02e-35 140.0 COG0348@1|root,COG0348@2|Bacteria,4NHSX@976|Bacteroidetes,1HYWP@117743|Flavobacteriia,2XIT4@283735|Leeuwenhoekiella 976|Bacteroidetes C 4Fe-4S binding domain yccM_2 - - - - - - - - - - - Fer4,Fer4_5,Fer4_7,Fer4_9 k59_1635136_1 1224746.B932_1274 2.08e-99 318.0 COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,2TQK9@28211|Alphaproteobacteria,2JP8R@204441|Rhodospirillales 204441|Rhodospirillales L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate uvrA - - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - ABC_tran k59_1635136_2 880072.Desac_2139 7.87e-63 206.0 COG1995@1|root,COG1995@2|Bacteria,1MX5W@1224|Proteobacteria,42NJJ@68525|delta/epsilon subdivisions,2WJGI@28221|Deltaproteobacteria,2MQFD@213462|Syntrophobacterales 28221|Deltaproteobacteria H Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) pdxA - 1.1.1.262,1.1.1.408,1.1.1.409 ko:K00097,ko:K22024 ko00750,ko01100,map00750,map01100 M00124 R05681,R05837,R07406 RC00089,RC00675,RC01475 ko00000,ko00001,ko00002,ko01000 - - - PdxA k59_338629_1 1415778.JQMM01000001_gene86 8.29e-122 359.0 COG2262@1|root,COG2262@2|Bacteria,1MUA0@1224|Proteobacteria,1RN7V@1236|Gammaproteobacteria,1J4RK@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis hflX GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0003924,GO:0005488,GO:0005524,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006414,GO:0006417,GO:0006464,GO:0006468,GO:0006518,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006996,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010608,GO:0016043,GO:0016310,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0018105,GO:0018193,GO:0018209,GO:0019001,GO:0019222,GO:0019538,GO:0019843,GO:0022411,GO:0030554,GO:0031323,GO:0031326,GO:0032268,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032559,GO:0032561,GO:0032790,GO:0032984,GO:0032988,GO:0034248,GO:0034641,GO:0034645,GO:0035639,GO:0036094,GO:0036211,GO:0036289,GO:0043021,GO:0043022,GO:0043023,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043603,GO:0043604,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0046777,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051246,GO:0060255,GO:0065007,GO:0071704,GO:0071826,GO:0071840,GO:0072344,GO:0080090,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903008,GO:2000112 - ko:K03665 - - - - ko00000,ko03009 - - - GTP-bdg_M,GTP-bdg_N,MMR_HSR1 k59_784085_2 1500894.JQNN01000001_gene4071 8.72e-30 120.0 COG3250@1|root,COG3250@2|Bacteria,1MVBN@1224|Proteobacteria 1224|Proteobacteria G Belongs to the glycosyl hydrolase 2 family uidA - 3.2.1.31 ko:K01195 ko00040,ko00531,ko00860,ko00944,ko00983,ko01100,ko01110,ko04142,map00040,map00531,map00860,map00944,map00983,map01100,map01110,map04142 M00014,M00076,M00077,M00078,M00129 R01478,R04979,R07818,R08127,R08260,R10830 RC00055,RC00171,RC00529,RC00530,RC00714,RC01251 ko00000,ko00001,ko00002,ko01000 - - - Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N k59_1010108_1 991.IW20_18710 1.37e-37 142.0 28N0Q@1|root,2ZB72@2|Bacteria,4NH9Z@976|Bacteroidetes,1HWND@117743|Flavobacteriia,2NUIU@237|Flavobacterium 976|Bacteroidetes - - - - - - - - - - - - - - - k59_903901_1 95619.PM1_0217380 1.05e-187 538.0 COG0504@1|root,COG0504@2|Bacteria,1MUIT@1224|Proteobacteria,1RM92@1236|Gammaproteobacteria 1236|Gammaproteobacteria F Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates pyrG GO:0003674,GO:0003824,GO:0003883,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006213,GO:0006220,GO:0006221,GO:0006241,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009208,GO:0009209,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046036,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 6.3.4.2 ko:K01937 ko00240,ko01100,map00240,map01100 M00052 R00571,R00573 RC00010,RC00074 ko00000,ko00001,ko00002,ko01000 - - iECO103_1326.ECO103_3323,iPC815.YPO3377 CTP_synth_N,GATase k59_1124508_1 706587.Desti_3199 1.26e-141 433.0 COG0458@1|root,COG0458@2|Bacteria,1MUDZ@1224|Proteobacteria,42MGK@68525|delta/epsilon subdivisions,2WJQH@28221|Deltaproteobacteria 28221|Deltaproteobacteria F Belongs to the CarB family carB - 6.3.5.5 ko:K01955 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - - CPSase_L_D2,CPSase_L_D3,MGS k59_1071593_1 391612.CY0110_25486 8.93e-34 138.0 COG0642@1|root,COG2202@1|root,COG3899@1|root,COG5002@1|root,COG2202@2|Bacteria,COG2205@2|Bacteria,COG3899@2|Bacteria,COG5002@2|Bacteria,1GD97@1117|Cyanobacteria,3KHHW@43988|Cyanothece 1117|Cyanobacteria T Serine Threonine protein kinase - - - - - - - - - - - - AAA_16,GAF,HATPase_c,HisKA,PAS_9,Response_reg k59_621009_1 1380347.JNII01000005_gene2995 4.49e-111 332.0 COG0232@1|root,COG0232@2|Bacteria,2GJ8F@201174|Actinobacteria,4ES2H@85013|Frankiales 201174|Actinobacteria F SMART Metal-dependent phosphohydrolase, HD region dgt - 3.1.5.1 ko:K01129 ko00230,map00230 - R01856 RC00017 ko00000,ko00001,ko01000 - - - HD,HD_assoc k59_1183268_1 926569.ANT_10080 6.2e-51 162.0 COG0185@1|root,COG0185@2|Bacteria,2G6US@200795|Chloroflexi 200795|Chloroflexi J Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA rpsS GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015935,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042274,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904 - ko:K02965 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S19 k59_1183268_2 926569.ANT_10090 1.88e-38 131.0 COG0091@1|root,COG0091@2|Bacteria,2G6ZQ@200795|Chloroflexi 200795|Chloroflexi J The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome rplV GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - ko:K02890 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L22 k59_1293847_1 1336208.JADY01000026_gene2278 1.42e-17 80.5 COG5285@1|root,COG5285@2|Bacteria,1N31I@1224|Proteobacteria,2U12W@28211|Alphaproteobacteria,2JVKY@204441|Rhodospirillales 204441|Rhodospirillales Q Phytanoyl-CoA dioxygenase (PhyH) - - 1.14.11.46 ko:K21195 ko00440,map00440 - R10724 RC01107 ko00000,ko00001,ko01000 - - - PhyH k59_733907_1 1121936.AUHI01000007_gene2359 2.36e-14 73.9 COG0508@1|root,COG0508@2|Bacteria,1TP3C@1239|Firmicutes,4HBVM@91061|Bacilli 91061|Bacilli C The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) odhB - 2.3.1.61 ko:K00658 ko00020,ko00310,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00032 R02570,R02571,R08549 RC00004,RC02727,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - 2-oxoacid_dh,Biotin_lipoyl,E3_binding k59_733907_2 485918.Cpin_5455 4.2e-20 90.1 COG1071@1|root,COG1071@2|Bacteria,4NF2J@976|Bacteroidetes,1IPU9@117747|Sphingobacteriia 976|Bacteroidetes C The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) pdhA - 1.2.4.1 ko:K00161 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230 M00307 R00014,R00209,R01699,R03270 RC00004,RC00027,RC00627,RC02742,RC02744,RC02882 br01601,ko00000,ko00001,ko00002,ko01000 - - - E1_dh k59_557597_2 1229909.NSED_03910 9.56e-66 206.0 COG0640@1|root,arCOG01686@2157|Archaea 2157|Archaea K regulatory protein, arsR - - - - - - - - - - - - HTH_20,HTH_5 k59_55443_1 1121918.ARWE01000001_gene3122 9.89e-58 196.0 COG1752@1|root,COG1752@2|Bacteria,1Q4S1@1224|Proteobacteria,42S86@68525|delta/epsilon subdivisions,2WNJA@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Patatin-like phospholipase - - - ko:K07001 - - - - ko00000 - - - Patatin k59_954764_1 1298593.TOL_0177 1.66e-44 152.0 COG0194@1|root,COG0194@2|Bacteria,1MW92@1224|Proteobacteria,1RN09@1236|Gammaproteobacteria,1XJ5P@135619|Oceanospirillales 135619|Oceanospirillales F Essential for recycling GMP and indirectly, cGMP gmk - 2.7.4.8 ko:K00942 ko00230,ko01100,map00230,map01100 M00050 R00332,R02090 RC00002 ko00000,ko00001,ko00002,ko01000 - - - Guanylate_kin k59_446622_1 1116472.MGMO_37c00170 1.9e-64 208.0 COG4974@1|root,COG4974@2|Bacteria,1MVNF@1224|Proteobacteria,1RPI8@1236|Gammaproteobacteria,1XDWR@135618|Methylococcales 135618|Methylococcales D recombinase XerD xerD - - ko:K04763 - - - - ko00000,ko03036 - - - Phage_int_SAM_1,Phage_integrase k59_1463623_1 1121374.KB891587_gene3100 4.39e-23 92.4 COG0200@1|root,COG0200@2|Bacteria,1RDC8@1224|Proteobacteria,1S3P6@1236|Gammaproteobacteria 1236|Gammaproteobacteria J binds to the 23S rRNA rplO GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02876 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L27A k59_1463623_2 1056820.KB900629_gene1691 2.28e-62 203.0 COG0201@1|root,COG0201@2|Bacteria,1MVU7@1224|Proteobacteria,1RNJV@1236|Gammaproteobacteria,2PMHG@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria U SecY translocase secY GO:0002790,GO:0003674,GO:0005048,GO:0005215,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006605,GO:0006612,GO:0006613,GO:0006614,GO:0006616,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0016043,GO:0022857,GO:0022884,GO:0031224,GO:0031226,GO:0031522,GO:0032940,GO:0032978,GO:0032991,GO:0033036,GO:0033218,GO:0033365,GO:0034613,GO:0042277,GO:0042886,GO:0042887,GO:0043952,GO:0044425,GO:0044459,GO:0044464,GO:0045047,GO:0045184,GO:0046903,GO:0046907,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0061024,GO:0065002,GO:0070727,GO:0070972,GO:0071702,GO:0071705,GO:0071806,GO:0071840,GO:0071944,GO:0072594,GO:0072599,GO:0072657,GO:0090150,GO:1904680 - ko:K03076 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5 - - SecY k59_280984_1 1121912.AUHD01000007_gene651 1.09e-110 330.0 COG0215@1|root,COG0215@2|Bacteria,4NE3Y@976|Bacteroidetes,1HY1F@117743|Flavobacteriia 976|Bacteroidetes J Belongs to the class-I aminoacyl-tRNA synthetase family cysS GO:0000166,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.1.1.16 ko:K01883 ko00970,map00970 M00359,M00360 R03650 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DALR_2,tRNA-synt_1e k59_1692627_1 1219080.VEZ01S_16_00420 8.66e-50 167.0 COG0863@1|root,COG0863@2|Bacteria,1R7KV@1224|Proteobacteria,1RZ25@1236|Gammaproteobacteria,1XUTY@135623|Vibrionales 135623|Vibrionales L DNA methylase VP0394 - 2.1.1.72 ko:K00571 - - - - ko00000,ko01000,ko02048 - - - N6_N4_Mtase k59_1185169_1 1268622.AVS7_02815 1.25e-47 166.0 COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2VIFS@28216|Betaproteobacteria,4A9PZ@80864|Comamonadaceae 28216|Betaproteobacteria C belongs to the aldehyde dehydrogenase family - - 1.2.1.3 ko:K00128 ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130 M00135 R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146 RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_1185169_2 95619.PM1_0229755 6.92e-132 385.0 COG0179@1|root,COG0179@2|Bacteria,1MV0V@1224|Proteobacteria,1RNYV@1236|Gammaproteobacteria 1236|Gammaproteobacteria Q 2-keto-4-pentenoate hydratase 2-oxohepta-3-ene-1,7-dioic acid hydratase - - 3.7.1.2 ko:K16171 ko00350,ko00643,ko01100,ko01120,map00350,map00643,map01100,map01120 M00044 R01364 RC00326,RC00446 ko00000,ko00001,ko00002,ko01000 - - - FAA_hydrolase k59_786241_1 1123360.thalar_03423 4.72e-49 167.0 COG0451@1|root,COG0451@2|Bacteria,1MWVJ@1224|Proteobacteria,2TRDY@28211|Alphaproteobacteria 28211|Alphaproteobacteria GM COG0451 Nucleoside-diphosphate-sugar epimerases - - - - - - - - - - - - Epimerase k59_786241_2 1122137.AQXF01000001_gene3198 5.06e-13 69.3 COG0457@1|root,COG0457@2|Bacteria,1RK4Q@1224|Proteobacteria,2UBBB@28211|Alphaproteobacteria 28211|Alphaproteobacteria S COG0457 FOG TPR repeat - - - - - - - - - - - - TPR_16,TPR_19,TPR_9 k59_448566_1 935840.JAEQ01000018_gene2029 4.72e-42 150.0 COG0404@1|root,COG0404@2|Bacteria,1MWZS@1224|Proteobacteria,2TSVD@28211|Alphaproteobacteria,43JE4@69277|Phyllobacteriaceae 28211|Alphaproteobacteria E Aminomethyltransferase folate-binding domain - - - ko:K15064 ko00627,ko01120,map00627,map01120 - R09270 RC00113,RC00392 ko00000,ko00001,ko01000 - - - GCV_T,GCV_T_C k59_1185185_1 498761.HM1_0057 4.52e-72 231.0 COG0518@1|root,COG0519@1|root,COG0518@2|Bacteria,COG0519@2|Bacteria,1TPG8@1239|Firmicutes,2487F@186801|Clostridia 186801|Clostridia F Catalyzes the synthesis of GMP from XMP guaA - 6.3.5.2 ko:K01951 ko00230,ko00983,ko01100,map00230,map00983,map01100 M00050 R01230,R01231,R08244 RC00010,RC00204 ko00000,ko00001,ko00002,ko01000,ko01002 - - - GATase,GMP_synt_C,NAD_synthase,tRNA_Me_trans k59_1126709_1 207954.MED92_13246 1.16e-56 191.0 COG0111@1|root,COG0111@2|Bacteria,1N5TD@1224|Proteobacteria,1RMFW@1236|Gammaproteobacteria,1XHAR@135619|Oceanospirillales 135619|Oceanospirillales H Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate pdxB - 1.1.1.290 ko:K03473 ko00750,ko01100,map00750,map01100 M00124 R04210 RC00084 ko00000,ko00001,ko00002,ko01000 - - - 2-Hacid_dh,2-Hacid_dh_C,DUF3410 k59_1465494_1 247634.GPB2148_1638 3.58e-95 289.0 COG1804@1|root,COG1804@2|Bacteria,1MW1H@1224|Proteobacteria,1RN9B@1236|Gammaproteobacteria,1J4MI@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C acyl-CoA transferases carnitine dehydratase - - 5.1.99.4 ko:K01796 ko00120,ko01100,ko04146,map00120,map01100,map04146 M00104 R08734,R08739 RC02345 ko00000,ko00001,ko00002,ko01000 - - - CoA_transf_3 k59_1295922_1 43989.cce_0544 3.05e-55 186.0 COG0598@1|root,COG0598@2|Bacteria,1G1AG@1117|Cyanobacteria,3KH5P@43988|Cyanothece 1117|Cyanobacteria P Mediates influx of magnesium ions corA - - ko:K03284 - - - - ko00000,ko02000 1.A.35.1,1.A.35.3 - - CorA k59_674713_1 1454202.PPBDW_90291___1 2.84e-17 87.4 COG1289@1|root,COG1289@2|Bacteria,1QJE4@1224|Proteobacteria,1THDF@1236|Gammaproteobacteria,1XU9P@135623|Vibrionales 135623|Vibrionales S Aromatic acid exporter family member 1 - - - - - - - - - - - - FUSC k59_1801865_2 1298867.AUES01000030_gene2524 1.42e-65 207.0 COG1024@1|root,COG1024@2|Bacteria,1MXBB@1224|Proteobacteria,2TSPM@28211|Alphaproteobacteria,3JSMT@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria I Enoyl-CoA hydratase/isomerase - - - - - - - - - - - - ECH_1 k59_1185210_1 983920.Y88_1057 1.89e-105 318.0 COG0056@1|root,COG0056@2|Bacteria,1MUG7@1224|Proteobacteria,2TQYK@28211|Alphaproteobacteria,2K08A@204457|Sphingomonadales 204457|Sphingomonadales C Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit atpA - 3.6.3.14 ko:K02111 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - - ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N k59_1241247_1 1229909.NSED_08635 1.92e-19 81.6 arCOG10592@1|root,arCOG10594@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_1241247_2 436308.Nmar_1596 6.67e-90 266.0 COG1607@1|root,arCOG00773@2157|Archaea,41T2J@651137|Thaumarchaeota 651137|Thaumarchaeota I Thioesterase superfamily - - - - - - - - - - - - 4HBT k59_1295927_2 1247963.JPHU01000001_gene1741 4.32e-54 174.0 COG4957@1|root,COG4957@2|Bacteria,1RGUW@1224|Proteobacteria,2U99M@28211|Alphaproteobacteria 28211|Alphaproteobacteria K Transcriptional regulator - - - - - - - - - - - - ROS_MUCR k59_1295927_3 1380390.JIAT01000009_gene367 4.64e-10 58.5 COG0698@1|root,COG0698@2|Bacteria,2GKJG@201174|Actinobacteria,4CQKW@84995|Rubrobacteria 84995|Rubrobacteria G Ribose/Galactose Isomerase - - 5.3.1.6 ko:K01808 ko00030,ko00051,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00051,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01056,R09030 RC00376,RC00434 ko00000,ko00001,ko00002,ko01000 - - - LacAB_rpiB k59_956853_1 1122137.AQXF01000001_gene3097 1.32e-24 94.4 COG0762@1|root,COG0762@2|Bacteria,1N73Q@1224|Proteobacteria,2UFZR@28211|Alphaproteobacteria 28211|Alphaproteobacteria S integral membrane protein MA20_25225 - - ko:K02221 - - - - ko00000,ko02044 - - - YGGT k59_956853_2 1122137.AQXF01000001_gene3098 1.63e-36 139.0 COG1520@1|root,COG1520@2|Bacteria,1P31B@1224|Proteobacteria,2U4EC@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane - - - - - - - - - - - - - k59_846031_1 1193729.A1OE_455 1.18e-17 77.0 COG0234@1|root,COG0234@2|Bacteria,1MZ2X@1224|Proteobacteria,2U9AQ@28211|Alphaproteobacteria,2JSPE@204441|Rhodospirillales 204441|Rhodospirillales O Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter groS - - ko:K04078 - - - - ko00000,ko03029,ko03110 - - - Cpn10 k59_1801881_1 436308.Nmar_0466 1.22e-47 162.0 arCOG08732@1|root,arCOG08732@2157|Archaea,41SR6@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1801881_2 1229909.NSED_02350 7.6e-25 92.8 arCOG08742@1|root,arCOG08742@2157|Archaea,41TAD@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1801881_3 1229909.NSED_02355 1.08e-93 288.0 arCOG08733@1|root,arCOG08733@2157|Archaea,41SRN@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_167841_1 1415778.JQMM01000001_gene1560 1.28e-33 129.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1J8Q0@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T Putative diguanylate phosphodiesterase - - - - - - - - - - - - EAL,GGDEF,PAS_3,PAS_4,PAS_9 k59_167841_2 87626.PTD2_00651 8.97e-24 91.3 COG2975@1|root,COG2975@2|Bacteria,1N7C1@1224|Proteobacteria,1SC9F@1236|Gammaproteobacteria,2Q3IZ@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria S Iron-sulphur cluster assembly iscX GO:0003674,GO:0004857,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006790,GO:0008150,GO:0008152,GO:0008198,GO:0009987,GO:0016043,GO:0016226,GO:0022607,GO:0030234,GO:0031163,GO:0043086,GO:0043167,GO:0043169,GO:0044085,GO:0044092,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0050790,GO:0051186,GO:0065007,GO:0065009,GO:0071840,GO:0098772 - - - - - - - - - - Fe-S_assembly k59_1295947_1 1137799.GZ78_11990 4.56e-26 107.0 COG0323@1|root,COG0323@2|Bacteria,1MV61@1224|Proteobacteria,1RM89@1236|Gammaproteobacteria,1XHJY@135619|Oceanospirillales 135619|Oceanospirillales L This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex mutL - - ko:K03572 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - DNA_mis_repair,HATPase_c_3,MutL_C k59_1295947_2 1169143.KB911038_gene6150 1.31e-20 88.6 COG3836@1|root,COG3836@2|Bacteria,1RCR7@1224|Proteobacteria,2WF9B@28216|Betaproteobacteria,1KCUA@119060|Burkholderiaceae 28216|Betaproteobacteria G HpcH/HpaI aldolase/citrate lyase family - - - - - - - - - - - - HpcH_HpaI k59_167844_1 338963.Pcar_0385 3.31e-76 245.0 COG1450@1|root,COG1450@2|Bacteria,1MVNC@1224|Proteobacteria,43BJ2@68525|delta/epsilon subdivisions,2X75C@28221|Deltaproteobacteria,43UGU@69541|Desulfuromonadales 28221|Deltaproteobacteria NU Secretin N-terminal domain - - - ko:K02453,ko:K12282 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - Secretin,Secretin_N_2 k59_1415384_1 631362.Thi970DRAFT_03334 1.39e-91 284.0 COG0459@1|root,COG0459@2|Bacteria,1MURR@1224|Proteobacteria,1RMTB@1236|Gammaproteobacteria,1WWXH@135613|Chromatiales 135613|Chromatiales O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions groL - - ko:K04077 ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 - - - Cpn60_TCP1 k59_1584870_1 1367847.JCM7686_1555 6.95e-10 59.3 COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,2TTN3@28211|Alphaproteobacteria,2PURK@265|Paracoccus 28211|Alphaproteobacteria EP Binding-protein-dependent transport system inner membrane component oppB - - ko:K15581 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00439 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 - - BPD_transp_1 k59_1584870_2 1122604.JONR01000006_gene2654 2.31e-37 140.0 COG4166@1|root,COG4166@2|Bacteria,1P91R@1224|Proteobacteria,1RN57@1236|Gammaproteobacteria,1X48I@135614|Xanthomonadales 135614|Xanthomonadales E Bacterial extracellular solute-binding proteins, family 5 Middle - - - ko:K15580 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00439 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 - - SBP_bac_5 k59_737957_1 1090320.KB900605_gene2344 7.63e-97 297.0 COG2303@1|root,COG2303@2|Bacteria,1MV19@1224|Proteobacteria,2TQKQ@28211|Alphaproteobacteria,2K0FF@204457|Sphingomonadales 204457|Sphingomonadales E Belongs to the GMC oxidoreductase family - - 1.1.99.1 ko:K00108 ko00260,ko01100,map00260,map01100 M00555 R01025 RC00087 ko00000,ko00001,ko00002,ko01000 - - - GMC_oxred_C,GMC_oxred_N k59_116515_1 1122137.AQXF01000001_gene3187 1.28e-61 204.0 COG0728@1|root,COG0728@2|Bacteria,1MUH0@1224|Proteobacteria,2TS44@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane murJ - - ko:K03980 - - - - ko00000,ko01011,ko02000 2.A.66.4 - - MVIN k59_116515_2 1122137.AQXF01000001_gene3186 1.29e-21 93.2 COG2844@1|root,COG2844@2|Bacteria,1MV54@1224|Proteobacteria,2TSV0@28211|Alphaproteobacteria 28211|Alphaproteobacteria O Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen glnD GO:0006355,GO:0006464,GO:0006807,GO:0006808,GO:0007154,GO:0007584,GO:0008150,GO:0008152,GO:0009605,GO:0009719,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0009991,GO:0010033,GO:0010243,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0018175,GO:0018177,GO:0019219,GO:0019222,GO:0019538,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031667,GO:0031668,GO:0031669,GO:0031670,GO:0036211,GO:0042221,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051716,GO:0060255,GO:0065007,GO:0070887,GO:0071310,GO:0071417,GO:0071495,GO:0071496,GO:0071704,GO:0080090,GO:0090293,GO:1901564,GO:1901698,GO:1901699,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141 2.7.7.59 ko:K00990 ko02020,map02020 - - - ko00000,ko00001,ko01000 - - - ACT,GlnD_UR_UTase,GlnE,HD,NTP_transf_2 k59_1754413_1 1313172.YM304_10250 1.47e-63 206.0 COG0395@1|root,COG0395@2|Bacteria,2GJNN@201174|Actinobacteria 201174|Actinobacteria G PFAM binding-protein-dependent transport systems inner membrane component - - - ko:K10234 ko02010,map02010 M00201 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.32,3.A.1.1.8 - - BPD_transp_1 k59_1754413_2 58344.JOEL01000047_gene2153 0.000159 43.5 COG1175@1|root,COG1175@2|Bacteria,2GKYS@201174|Actinobacteria 201174|Actinobacteria G PFAM binding-protein-dependent transport systems inner membrane component - - - ko:K02025,ko:K10233 ko02010,map02010 M00201,M00207 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1,3.A.1.1.32,3.A.1.1.8 - - BPD_transp_1,CarboxypepD_reg k59_794294_1 1208323.B30_04537 3.25e-94 286.0 COG0500@1|root,COG2226@2|Bacteria,1MVXN@1224|Proteobacteria,2TR8A@28211|Alphaproteobacteria 28211|Alphaproteobacteria Q COG0500 SAM-dependent methyltransferases - - 2.1.1.137 ko:K07755 - - - - ko00000,ko01000 - - - Methyltransf_11,Methyltransf_31 k59_229025_1 479433.Caci_1554 1.43e-22 102.0 COG0477@1|root,COG0477@2|Bacteria,2GIUM@201174|Actinobacteria 201174|Actinobacteria EGP Major facilitator superfamily - - - - - - - - - - - - MFS_1 k59_1020423_1 1042377.AFPJ01000028_gene2161 2.05e-43 148.0 2B4XH@1|root,31XQC@2|Bacteria,1RHJF@1224|Proteobacteria,1S3S1@1236|Gammaproteobacteria,467JQ@72275|Alteromonadaceae 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_737969_1 391615.ABSJ01000036_gene976 3.14e-155 444.0 COG0050@1|root,COG0050@2|Bacteria,1MVC0@1224|Proteobacteria,1RMYX@1236|Gammaproteobacteria,1J5DE@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis tuf GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - ko:K02358 - - - - ko00000,ko03012,ko03029,ko04147 - - - GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3 k59_455139_1 452662.SJA_C1-23550 3.89e-40 149.0 COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,2TRMU@28211|Alphaproteobacteria,2K09N@204457|Sphingomonadales 204457|Sphingomonadales NU General secretion pathway protein E gspE - - ko:K02454 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - T2SSE,T2SSE_N k59_1697970_1 1123073.KB899241_gene3423 1.03e-39 146.0 COG0823@1|root,COG0823@2|Bacteria,1MV09@1224|Proteobacteria,1RMCY@1236|Gammaproteobacteria,1X3CZ@135614|Xanthomonadales 135614|Xanthomonadales U Involved in the TonB-independent uptake of proteins tolB - - ko:K03641 - - - - ko00000,ko02000 2.C.1.2 - - PD40,TolB_N k59_1641607_1 498211.CJA_2286 2.73e-65 218.0 COG0616@1|root,COG0616@2|Bacteria,1MUXE@1224|Proteobacteria,1RNYW@1236|Gammaproteobacteria,1FGS8@10|Cellvibrio 1236|Gammaproteobacteria OU Peptidase family S49 sppA GO:0003674,GO:0003824,GO:0004175,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006465,GO:0006508,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009987,GO:0010467,GO:0016020,GO:0016021,GO:0016485,GO:0016787,GO:0019538,GO:0031224,GO:0031226,GO:0034641,GO:0043170,GO:0043603,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0051604,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564 - ko:K04773 - - - - ko00000,ko01000,ko01002 - - - Peptidase_S49 k59_624576_1 1266914.ATUK01000015_gene836 5.36e-118 347.0 COG3328@1|root,COG3328@2|Bacteria,1MU4P@1224|Proteobacteria,1RNB3@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Transposase - - - - - - - - - - - - Transposase_mut k59_1302715_1 247634.GPB2148_899 5.63e-64 213.0 COG0859@1|root,COG0859@2|Bacteria,1MXA2@1224|Proteobacteria,1RMBF@1236|Gammaproteobacteria,1J4K0@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M COG0859 ADP-heptose LPS heptosyltransferase - - - ko:K02843 ko00540,ko01100,map00540,map01100 M00080 - - ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT9 - Glyco_transf_9 k59_455148_1 28229.ND2E_3607 2.77e-15 77.0 COG1737@1|root,COG1737@2|Bacteria,1MV3U@1224|Proteobacteria,1RNC4@1236|Gammaproteobacteria,2Q6F3@267889|Colwelliaceae 1236|Gammaproteobacteria K Helix-turn-helix domain, rpiR family hexR GO:0000976,GO:0001067,GO:0001130,GO:0001131,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0006950,GO:0006974,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032991,GO:0032993,GO:0033554,GO:0043565,GO:0044212,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051716,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2001141 - ko:K19337 - - - - ko00000,ko03000 - - - HTH_6,SIS k59_229036_1 1122137.AQXF01000003_gene2424 3.98e-73 226.0 COG5388@1|root,COG5388@2|Bacteria,1Q47N@1224|Proteobacteria,2UME7@28211|Alphaproteobacteria 28211|Alphaproteobacteria S PAS domain - - - - - - - - - - - - PAS_5 k59_229036_2 1122137.AQXF01000003_gene2425 5.89e-09 54.3 COG1846@1|root,COG1846@2|Bacteria,1RIX7@1224|Proteobacteria,2U94M@28211|Alphaproteobacteria 28211|Alphaproteobacteria K transcriptional regulator petP - - - - - - - - - - - MarR_2 k59_1584907_1 1042377.AFPJ01000034_gene2415 1.46e-83 256.0 COG1225@1|root,COG1225@2|Bacteria,1MWFZ@1224|Proteobacteria,1RZ28@1236|Gammaproteobacteria,46CDJ@72275|Alteromonadaceae 1236|Gammaproteobacteria O Redoxin - - - - - - - - - - - - AhpC-TSA k59_511530_1 1173023.KE650771_gene2550 4.65e-07 52.8 COG3176@1|root,COG3176@2|Bacteria,1GBXT@1117|Cyanobacteria,1JJHF@1189|Stigonemataceae 1117|Cyanobacteria S Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_5 k59_906845_1 305700.B447_20710 4.19e-47 172.0 COG1305@1|root,COG4196@1|root,COG1305@2|Bacteria,COG4196@2|Bacteria,1MVAG@1224|Proteobacteria,2VKKZ@28216|Betaproteobacteria,2KV93@206389|Rhodocyclales 206389|Rhodocyclales E Putative amidoligase enzyme (DUF2126) - - - - - - - - - - - - Bact_transglu_N,DUF2126,Transglut_core k59_624594_1 180332.JTGN01000003_gene1913 4.43e-16 82.8 arCOG05143@1|root,2Z8AM@2|Bacteria,1TSB3@1239|Firmicutes,24IYX@186801|Clostridia 186801|Clostridia S Monomethylamine methyltransferase MtmB - - 2.1.1.248 ko:K16176 ko00680,ko01120,ko01200,map00680,map01120,map01200 M00563 R09998,R10014 RC00035,RC01144,RC02985 ko00000,ko00001,ko00002,ko01000 - - - MtmB k59_794338_1 128390.XP_009461655.1 5.83e-15 81.3 COG0010@1|root,KOG2964@2759|Eukaryota,38BX2@33154|Opisthokonta,3BEYH@33208|Metazoa,3CU68@33213|Bilateria,4825I@7711|Chordata,496WN@7742|Vertebrata,4GQIR@8782|Aves 33208|Metazoa E Belongs to the arginase family AGMAT GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0006807,GO:0008150,GO:0008152,GO:0008783,GO:0009058,GO:0016787,GO:0016810,GO:0016813,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0097055,GO:1901160,GO:1901162,GO:1901564,GO:1901566,GO:1901576 3.5.3.11 ko:K01480 ko00330,ko01100,map00330,map01100 M00133 R01157 RC00024,RC00329 ko00000,ko00001,ko00002,ko01000 - - - Arginase k59_1302752_1 436308.Nmar_1389 1.04e-36 130.0 COG0543@1|root,arCOG02199@2157|Archaea,41SY5@651137|Thaumarchaeota 651137|Thaumarchaeota H Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B - - - ko:K02823 ko00240,ko01100,map00240,map01100 - - - ko00000,ko00001 - - - DHODB_Fe-S_bind,NAD_binding_1 k59_1360034_2 439375.Oant_3191 5.6e-09 61.6 COG0741@1|root,COG0741@2|Bacteria,1MZ4X@1224|Proteobacteria,2TU56@28211|Alphaproteobacteria,1J418@118882|Brucellaceae 28211|Alphaproteobacteria M Transglycosylase SLT domain - - - - - - - - - - - - SLT k59_1642623_1 983917.RGE_02200 6.24e-87 267.0 COG1975@1|root,COG1975@2|Bacteria,1MXKU@1224|Proteobacteria,2VHIK@28216|Betaproteobacteria,1KIZ4@119065|unclassified Burkholderiales 28216|Betaproteobacteria O XdhC Rossmann domain - - - ko:K07402 - - - - ko00000 - - - XdhC_C,XdhC_CoxI k59_117438_1 330214.NIDE0994 1.27e-73 236.0 COG1730@1|root,COG1730@2|Bacteria 2|Bacteria O sister chromatid segregation - - - - - - - - - - - - - k59_399653_1 504487.JCM19302_939 7.65e-71 218.0 COG0457@1|root,COG0457@2|Bacteria,4NRIH@976|Bacteroidetes,1I1SZ@117743|Flavobacteriia 976|Bacteroidetes S Protein of unknown function (DUF2911) - - - - - - - - - - - - DUF2911 k59_907963_1 570952.ATVH01000014_gene1996 1.47e-35 128.0 COG1495@1|root,COG1495@2|Bacteria,1N89I@1224|Proteobacteria,2UF49@28211|Alphaproteobacteria,2JTU4@204441|Rhodospirillales 204441|Rhodospirillales O bond formation protein, DsbB - - - - - - - - - - - - DsbB k59_907963_2 1122137.AQXF01000001_gene2839 3.11e-29 109.0 COG2941@1|root,COG2941@2|Bacteria,1RAK4@1224|Proteobacteria,2U85I@28211|Alphaproteobacteria 28211|Alphaproteobacteria H Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol coq7 - - ko:K06134 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00128 R04984,R08775 RC01254 ko00000,ko00001,ko00002,ko01000 - - - COQ7 k59_851693_1 1090320.KB900605_gene2352 2.75e-17 80.9 COG0583@1|root,COG0583@2|Bacteria,1MXDT@1224|Proteobacteria,2TRY1@28211|Alphaproteobacteria,2K9PJ@204457|Sphingomonadales 204457|Sphingomonadales K Bacterial regulatory helix-turn-helix protein, lysR family - - - - - - - - - - - - HTH_1,LysR_substrate k59_851693_2 246200.SPO0205 5.41e-97 305.0 COG2079@1|root,COG2079@2|Bacteria,1R5UM@1224|Proteobacteria,2U1F8@28211|Alphaproteobacteria,4NBWV@97050|Ruegeria 28211|Alphaproteobacteria S MmgE/PrpD family - - - - - - - - - - - - MmgE_PrpD k59_1529549_2 1229909.NSED_02695 4.99e-54 172.0 COG2004@1|root,arCOG04182@2157|Archaea,41SWI@651137|Thaumarchaeota 651137|Thaumarchaeota J Belongs to the eukaryotic ribosomal protein eS24 family - - - ko:K02974 ko03010,map03010 M00177,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - - k59_795219_1 314287.GB2207_09446 2.32e-93 300.0 COG1033@1|root,COG1033@2|Bacteria,1MUE1@1224|Proteobacteria,1RNWM@1236|Gammaproteobacteria,1J4YY@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S exporters of the RND superfamily - - - ko:K07003 - - - - ko00000 - - - MMPL k59_1303622_1 396588.Tgr7_1535 7.37e-51 177.0 COG0188@1|root,COG0188@2|Bacteria,1MUGG@1224|Proteobacteria,1RN03@1236|Gammaproteobacteria,1WXK8@135613|Chromatiales 135613|Chromatiales L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrA - 5.99.1.3 ko:K02469 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseA_C,DNA_topoisoIV k59_1303622_2 396588.Tgr7_1531 7.29e-12 65.1 COG0402@1|root,COG0402@2|Bacteria,1MVPA@1224|Proteobacteria,1RN13@1236|Gammaproteobacteria,1WWJ0@135613|Chromatiales 135613|Chromatiales F Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine mtaD - 3.5.4.28,3.5.4.31 ko:K12960 ko00270,ko01100,map00270,map01100 - R09660 RC00477 ko00000,ko00001,ko01000 - - - Amidohydro_1 k59_739022_1 383381.EH30_00805 2.57e-73 243.0 COG0758@1|root,COG0758@2|Bacteria,1R9P1@1224|Proteobacteria,2U30Q@28211|Alphaproteobacteria,2K3JF@204457|Sphingomonadales 204457|Sphingomonadales LU DNA mediated transformation - - - - - - - - - - - - - k59_1190717_1 530564.Psta_4529 2.87e-77 254.0 COG0745@1|root,COG1716@1|root,COG5002@1|root,COG0745@2|Bacteria,COG1716@2|Bacteria,COG5002@2|Bacteria,2J4Z7@203682|Planctomycetes 203682|Planctomycetes T SMART ATP-binding region ATPase domain protein - - - - - - - - - - - - HATPase_c,HisKA,Hpt,PAS_4,PAS_9,Response_reg k59_1190717_2 1121033.AUCF01000005_gene5158 8.21e-56 180.0 COG3829@1|root,COG3829@2|Bacteria,1RH32@1224|Proteobacteria,2U79H@28211|Alphaproteobacteria,2JS7C@204441|Rhodospirillales 204441|Rhodospirillales KT COG2202 FOG PAS PAC domain - - - - - - - - - - - - PAS_3 k59_60982_1 398578.Daci_1594 0.000204 48.9 COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,2VI4Q@28216|Betaproteobacteria,4A9SZ@80864|Comamonadaceae 28216|Betaproteobacteria O Belongs to the peptidase S1C family mucD - 3.4.21.107 ko:K04771 ko01503,ko02020,map01503,map02020 M00728 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 - - - PDZ_2,Trypsin_2 k59_399683_2 1042377.AFPJ01000037_gene2895 1.44e-80 251.0 COG0763@1|root,COG0763@2|Bacteria,1MVBI@1224|Proteobacteria,1RNS1@1236|Gammaproteobacteria,465R6@72275|Alteromonadaceae 1236|Gammaproteobacteria M Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell lpxB GO:0003674,GO:0003824,GO:0005488,GO:0005543,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008194,GO:0008289,GO:0008610,GO:0008654,GO:0008915,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0019637,GO:0019897,GO:0019898,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0046467,GO:0046493,GO:0071704,GO:0071944,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 2.4.1.182 ko:K00748 ko00540,ko01100,map00540,map01100 M00060 R04606 RC00005,RC00059 ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT19 iE2348C_1286.E2348C_0187,iEcolC_1368.EcolC_3478 LpxB k59_286983_1 1154860.SAG0136_03850 3.44e-31 118.0 COG0244@1|root,COG0244@2|Bacteria,1V3JJ@1239|Firmicutes,4HH0N@91061|Bacilli 91061|Bacilli J Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors rplJ GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02864 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L10 k59_286983_2 391735.Veis_2263 5.38e-12 63.5 COG0222@1|root,COG0222@2|Bacteria,1RGU4@1224|Proteobacteria,2VSG7@28216|Betaproteobacteria,4AE42@80864|Comamonadaceae 28216|Betaproteobacteria J Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation rplL - - ko:K02935 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L12,Ribosomal_L12_N k59_1303643_1 94122.Shewana3_0919 1.47e-32 123.0 28KDQ@1|root,2ZA05@2|Bacteria,1QE8C@1224|Proteobacteria,1S0JF@1236|Gammaproteobacteria,2QDSI@267890|Shewanellaceae 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_908004_1 123214.PERMA_0609 7.75e-53 183.0 COG0171@1|root,COG0388@1|root,COG0171@2|Bacteria,COG0388@2|Bacteria,2G425@200783|Aquificae 200783|Aquificae H Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source nadE GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008795,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016874,GO:0016879,GO:0016880,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.1.5,6.3.5.1 ko:K01916,ko:K01950 ko00760,ko01100,map00760,map01100 M00115 R00189,R00257 RC00010,RC00100 ko00000,ko00001,ko00002,ko01000 - - - CN_hydrolase,NAD_synthase k59_1190740_1 1380370.JIBA01000015_gene376 4.84e-76 252.0 COG0642@1|root,COG2205@2|Bacteria,2I2M2@201174|Actinobacteria,4FFYD@85021|Intrasporangiaceae 201174|Actinobacteria T GAF domain - - - - - - - - - - - - DUF3365,GAF_2,HAMP,HATPase_c,HisKA,Response_reg k59_1190740_2 1380370.JIBA01000015_gene375 3.61e-07 49.7 COG0784@1|root,COG0784@2|Bacteria,2IMYZ@201174|Actinobacteria 201174|Actinobacteria T cheY-homologous receiver domain - - - - - - - - - - - - Response_reg k59_1473075_1 330214.NIDE3435 2.06e-47 165.0 COG1131@1|root,COG1131@2|Bacteria,3J122@40117|Nitrospirae 40117|Nitrospirae V AAA domain, putative AbiEii toxin, Type IV TA system - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_1473075_2 330214.NIDE3434 2.5e-08 55.5 COG1277@1|root,COG1277@2|Bacteria 2|Bacteria - - pilI - - - - - - - - - - - ABC2_membrane_2 k59_230069_1 118168.MC7420_4981 3.16e-35 146.0 COG0642@1|root,COG2202@1|root,COG4251@1|root,COG0642@2|Bacteria,COG2202@2|Bacteria,COG2205@2|Bacteria,COG4251@2|Bacteria,1G09B@1117|Cyanobacteria,1H82F@1150|Oscillatoriales 1117|Cyanobacteria T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - CHASE4,GAF,GAF_3,HAMP,HATPase_c,HisKA,Hpt,PAS,PAS_3,PAS_4,PAS_9,Response_reg k59_230069_2 1035195.HMPREF9997_00934 1.27e-19 90.9 COG0745@1|root,COG0745@2|Bacteria,2GIZB@201174|Actinobacteria,22K1X@1653|Corynebacteriaceae 201174|Actinobacteria KT Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain mprA GO:0000160,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006355,GO:0007154,GO:0007165,GO:0008150,GO:0009268,GO:0009628,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0010446,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0016020,GO:0019219,GO:0019222,GO:0023052,GO:0030312,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0035556,GO:0043254,GO:0044087,GO:0044464,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0051716,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:0090034,GO:0097159,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:2000112,GO:2000113,GO:2001141 - ko:K07669,ko:K07672 ko02020,map02020 M00460,M00463 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Trans_reg_C k59_1699011_1 1122137.AQXF01000003_gene2324 0.000337 42.0 COG0751@1|root,COG0751@2|Bacteria,1MV2F@1224|Proteobacteria,2TQKJ@28211|Alphaproteobacteria 28211|Alphaproteobacteria J Glycyl-tRNA synthetase beta subunit glyS - 6.1.1.14 ko:K01879 ko00970,map00970 M00360 R03654 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DALR_1,tRNA_synt_2f k59_1699011_2 1122137.AQXF01000003_gene2325 5.78e-148 442.0 COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MU0R@1224|Proteobacteria,2TR3C@28211|Alphaproteobacteria 28211|Alphaproteobacteria G Pyruvate phosphate dikinase ppdK - 2.7.9.1 ko:K01006 ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200 M00169,M00171,M00172,M00173 R00206 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - PEP-utilizers,PEP-utilizers_C,PPDK_N k59_1755452_1 1268635.Loa_01188 3.88e-17 79.7 COG0739@1|root,COG0739@2|Bacteria,1MY2X@1224|Proteobacteria,1RMYN@1236|Gammaproteobacteria,1JDDH@118969|Legionellales 118969|Legionellales M Peptidase family M23 - - - - - - - - - - - - Peptidase_M23 k59_1755452_2 472759.Nhal_0659 2.24e-36 137.0 COG0119@1|root,COG0119@2|Bacteria,1MUNQ@1224|Proteobacteria,1RMWE@1236|Gammaproteobacteria,1WWU2@135613|Chromatiales 135613|Chromatiales E Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) leuA - 2.3.3.13 ko:K01649 ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230 M00432 R01213 RC00004,RC00470,RC02754 br01601,ko00000,ko00001,ko00002,ko01000 - - - HMGL-like,LeuA_dimer k59_1416346_1 521098.Aaci_0499 2.06e-20 95.5 COG2801@1|root,COG2801@2|Bacteria,1TT8V@1239|Firmicutes,4HCE5@91061|Bacilli,279CZ@186823|Alicyclobacillaceae 91061|Bacilli L PFAM Integrase catalytic region - - - - - - - - - - - - HTH_23,HTH_28,HTH_29,rve k59_569196_1 555778.Hneap_1330 1.46e-101 310.0 COG0539@1|root,COG0539@2|Bacteria,1MVAV@1224|Proteobacteria,1RMFY@1236|Gammaproteobacteria,1WVVK@135613|Chromatiales 135613|Chromatiales J thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence rpsA - - ko:K02945 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - S1 k59_1077454_1 285535.JOEY01000054_gene2962 1.56e-29 118.0 COG1028@1|root,COG1028@2|Bacteria,2IGQ3@201174|Actinobacteria 201174|Actinobacteria IQ Enoyl-(Acyl carrier protein) reductase - - - - - - - - - - - - adh_short_C2 k59_512542_1 1229909.NSED_04915 2.38e-20 83.6 COG0640@1|root,arCOG03067@2157|Archaea,41T4C@651137|Thaumarchaeota 651137|Thaumarchaeota K transcriptional regulators - - - - - - - - - - - - HTH_20 k59_512542_2 436308.Nmar_0878 6.34e-101 298.0 arCOG06353@1|root,arCOG06353@2157|Archaea,41SI1@651137|Thaumarchaeota 651137|Thaumarchaeota P Probable cobalt transporter subunit (CbtA) - - - - - - - - - - - - CbtA k59_456202_1 1125973.JNLC01000010_gene1214 1.3e-107 339.0 COG0842@1|root,COG1129@1|root,COG0842@2|Bacteria,COG1129@2|Bacteria,1QTT9@1224|Proteobacteria,2TW58@28211|Alphaproteobacteria,3JW0I@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria V ABC transporter - - - ko:K13926 - - - - ko00000 - - - ABC2_membrane_3,ABC_tran k59_1077473_1 105420.BBPO01000068_gene3894 9.4e-43 160.0 COG2890@1|root,COG2890@2|Bacteria,2GJPP@201174|Actinobacteria,2NGJQ@228398|Streptacidiphilus 201174|Actinobacteria J Ribosomal protein L11 methyltransferase (PrmA) rsmC - - - - - - - - - - - MTS k59_4306_1 159450.NH14_25070 1.09e-106 318.0 COG0183@1|root,COG0183@2|Bacteria,1MU8C@1224|Proteobacteria,2VM0D@28216|Betaproteobacteria,1K48Y@119060|Burkholderiaceae 28216|Betaproteobacteria I Belongs to the thiolase family - - 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N k59_61023_1 926569.ANT_25700 1.67e-05 52.4 COG0265@1|root,COG0642@1|root,COG2203@1|root,COG0265@2|Bacteria,COG2203@2|Bacteria,COG2205@2|Bacteria,2G7SE@200795|Chloroflexi 200795|Chloroflexi T histidine kinase A domain protein - - - - - - - - - - - - GAF_2,HATPase_c,HisKA k59_682048_1 1163408.UU9_06684 2.17e-06 50.4 COG2976@1|root,COG2976@2|Bacteria,1N117@1224|Proteobacteria,1S95P@1236|Gammaproteobacteria,1X733@135614|Xanthomonadales 135614|Xanthomonadales S protein conserved in bacteria - - - - - - - - - - - - TPR_21 k59_682048_2 1452718.JBOY01000023_gene278 9.02e-22 95.5 COG0124@1|root,COG0124@2|Bacteria,1MV2K@1224|Proteobacteria,1RPHI@1236|Gammaproteobacteria 1236|Gammaproteobacteria J histidyl-tRNA synthetase hisS GO:0003674,GO:0003824,GO:0004812,GO:0004821,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006427,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.21 ko:K01892 ko00970,map00970 M00359,M00360 R03655 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iE2348C_1286.E2348C_2797,iECNA114_1301.ECNA114_2592,iECSF_1327.ECSF_2358 HGTP_anticodon,tRNA-synt_His k59_1585918_1 1229909.NSED_03750 2.68e-159 461.0 COG0553@1|root,arCOG00883@2157|Archaea,41T0G@651137|Thaumarchaeota 651137|Thaumarchaeota K SNF2 family N-terminal domain - - - - - - - - - - - - Helicase_C,SNF2_N k59_964645_1 1122225.AULQ01000011_gene85 7e-125 385.0 COG0612@1|root,COG0612@2|Bacteria,4NFY0@976|Bacteroidetes,1HYNJ@117743|Flavobacteriia 976|Bacteroidetes S Belongs to the peptidase M16 family pqqL - - ko:K07263 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M16,Peptidase_M16_C k59_625588_1 379066.GAU_2866 4.1e-45 167.0 COG0642@1|root,COG0745@1|root,COG2198@1|root,COG2202@1|root,COG0642@2|Bacteria,COG0745@2|Bacteria,COG2198@2|Bacteria,COG2202@2|Bacteria,1ZUEC@142182|Gemmatimonadetes 142182|Gemmatimonadetes T Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) - - - - - - - - - - - - HATPase_c,HisKA,Hpt,PAS_3,Response_reg k59_1303706_1 1192034.CAP_5632 0.000513 48.5 COG0745@1|root,COG3437@1|root,COG3667@1|root,COG0745@2|Bacteria,COG3437@2|Bacteria,COG3667@2|Bacteria,1QXU5@1224|Proteobacteria,43C6N@68525|delta/epsilon subdivisions,2X7GW@28221|Deltaproteobacteria,2YUUA@29|Myxococcales 28221|Deltaproteobacteria T HD domain - - - - - - - - - - - - DUF4388,HD_5,Response_reg,T2SSE_N k59_1134165_1 1297742.A176_01323 2.77e-36 128.0 COG0662@1|root,COG0662@2|Bacteria,1NADF@1224|Proteobacteria,4383M@68525|delta/epsilon subdivisions,2X9WE@28221|Deltaproteobacteria,2YVKF@29|Myxococcales 28221|Deltaproteobacteria G Mannose-6-phosphate isomerase - - - - - - - - - - - - Cupin_2 k59_1642697_3 1502724.FF80_03359 4.32e-22 91.3 2E4R2@1|root,32ZJM@2|Bacteria,1N9RQ@1224|Proteobacteria,2UFU4@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_1190781_1 504487.JCM19302_241 4.52e-92 281.0 COG1257@1|root,COG1257@2|Bacteria,4NGNG@976|Bacteroidetes,1HY0M@117743|Flavobacteriia 976|Bacteroidetes I Belongs to the HMG-CoA reductase family mvaA - 1.1.1.88 ko:K00054 ko00900,ko01110,ko01130,map00900,map01110,map01130 - R02081 RC00004,RC00644 ko00000,ko00001,ko01000 - - - HMG-CoA_red k59_682088_1 396588.Tgr7_1490 4.92e-28 112.0 COG1721@1|root,COG1721@2|Bacteria,1R3QD@1224|Proteobacteria,1S5F7@1236|Gammaproteobacteria,1WWD0@135613|Chromatiales 135613|Chromatiales S Protein of unknown function DUF58 - - - - - - - - - - - - DUF58 k59_181628_2 522306.CAP2UW1_2689 7.42e-10 60.1 COG0224@1|root,COG0224@2|Bacteria,1RIE5@1224|Proteobacteria,2VYNF@28216|Betaproteobacteria 28216|Betaproteobacteria C ATP synthase - - - ko:K02115 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt k59_181629_2 384765.SIAM614_23942 1.62e-36 126.0 COG3492@1|root,COG3492@2|Bacteria,1MZ3I@1224|Proteobacteria,2UC11@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Protein conserved in bacteria MA20_03865 - - ko:K09948 - - - - ko00000 - - - DUF1244 k59_1198341_1 1144305.PMI02_01950 3.33e-120 360.0 COG1368@1|root,COG1368@2|Bacteria,1MXT1@1224|Proteobacteria,2U7II@28211|Alphaproteobacteria,2K3E3@204457|Sphingomonadales 204457|Sphingomonadales M Sulfatase - - - - - - - - - - - - Sulfatase k59_576963_1 313598.MED152_06555 1.05e-60 201.0 COG0750@1|root,COG0750@2|Bacteria,4NEAR@976|Bacteroidetes,1HXEV@117743|Flavobacteriia,3VW1A@52959|Polaribacter 976|Bacteroidetes M Peptidase family M50 rseP - - ko:K11749 ko02024,ko04112,map02024,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - PDZ,PDZ_2,Peptidase_M50 k59_804180_1 1121127.JAFA01000003_gene2230 3.08e-27 112.0 COG2267@1|root,COG2267@2|Bacteria,1MW9H@1224|Proteobacteria,2VMHB@28216|Betaproteobacteria,1K32Y@119060|Burkholderiaceae 28216|Betaproteobacteria I Alpha beta hydrolase - - - - - - - - - - - - Abhydrolase_1 k59_464551_1 1207063.P24_11477 1.73e-114 351.0 COG0365@1|root,COG0365@2|Bacteria,1MUX7@1224|Proteobacteria,2TRND@28211|Alphaproteobacteria,2JPUS@204441|Rhodospirillales 204441|Rhodospirillales I COG0365 Acyl-coenzyme A synthetases AMP-(fatty) acid ligases - - 6.2.1.16 ko:K01907 ko00280,ko00650,map00280,map00650 - R01357 RC00004,RC00014 ko00000,ko00001,ko01000,ko01004 - - - ACAS_N,AMP-binding,AMP-binding_C k59_464551_2 999541.bgla_1g17640 5.43e-14 70.9 COG0644@1|root,COG2440@1|root,COG0644@2|Bacteria,COG2440@2|Bacteria,1MVU6@1224|Proteobacteria,2VH37@28216|Betaproteobacteria,1K2GN@119060|Burkholderiaceae 28216|Betaproteobacteria C electron transfer flavoprotein-ubiquinone oxidoreductase etf - 1.5.5.1 ko:K00311 - - - - ko00000,ko01000 - - - ETF_QO,FAD_binding_2,NAD_binding_8 k59_408326_1 436308.Nmar_0774 2.26e-138 396.0 COG0805@1|root,arCOG01919@2157|Archaea,41S69@651137|Thaumarchaeota 651137|Thaumarchaeota U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes tatC - - ko:K03118 ko03060,ko03070,map03060,map03070 M00336 - - ko00000,ko00001,ko00002,ko02044 2.A.64 - - TatC k59_1764059_1 1229909.NSED_02555 5.97e-63 201.0 COG0113@1|root,arCOG04300@2157|Archaea,41SET@651137|Thaumarchaeota 651137|Thaumarchaeota H Delta-aminolevulinic acid dehydratase - - 4.2.1.24 ko:K01698 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R00036 RC00918,RC01781 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ALAD k59_1764059_2 436308.Nmar_0508 5.81e-30 108.0 arCOG08763@1|root,arCOG08763@2157|Archaea,41SWC@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_464566_1 1244869.H261_21656 1.37e-67 230.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2TQS3@28211|Alphaproteobacteria,2JQ4H@204441|Rhodospirillales 204441|Rhodospirillales T signal transduction protein containing a membrane domain, an EAL and a GGDEF domain - - - - - - - - - - - - CBS,EAL,GGDEF,PAS_9 k59_295870_3 411483.FAEPRAA2165_03038 1.64e-09 60.5 COG3191@1|root,COG3191@2|Bacteria,1TQHA@1239|Firmicutes,24CV6@186801|Clostridia,3WNCI@541000|Ruminococcaceae 186801|Clostridia EQ Peptidase family S58 dmpA - 3.4.11.19 ko:K01266 - - - - ko00000,ko01000,ko01002 - - - Peptidase_S58 k59_352280_1 1121937.AUHJ01000004_gene1054 1.45e-24 100.0 COG2930@1|root,COG2930@2|Bacteria,1RCYH@1224|Proteobacteria,1S41U@1236|Gammaproteobacteria,46AZS@72275|Alteromonadaceae 1236|Gammaproteobacteria S Las17-binding protein actin regulator CT2216 - - - - - - - - - - - Ysc84 k59_634097_1 44060.JODL01000019_gene4749 1.9e-20 92.0 COG0778@1|root,COG1478@1|root,COG0778@2|Bacteria,COG1478@2|Bacteria,2GMJ8@201174|Actinobacteria 201174|Actinobacteria C Catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives fbiB GO:0005575,GO:0005623,GO:0005886,GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016020,GO:0044237,GO:0044249,GO:0044464,GO:0051186,GO:0051188,GO:0071944 6.3.2.31,6.3.2.34 ko:K12234 ko00680,ko01120,map00680,map01120 M00378 R09399,R09400 RC00064,RC00090,RC00141 ko00000,ko00001,ko00002,ko01000 - - - F420_ligase,Nitroreductase k59_634097_2 1121106.JQKB01000008_gene1357 1.17e-49 167.0 COG0391@1|root,COG0391@2|Bacteria,1NK78@1224|Proteobacteria,2TUUA@28211|Alphaproteobacteria 28211|Alphaproteobacteria S LPPG Fo 2-phospho-L-lactate transferase cofD - 2.7.8.28 ko:K11212 ko00680,ko01120,map00680,map01120 M00378 R09398 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - UPF0052 k59_295881_1 436308.Nmar_1488 2.93e-81 258.0 COG0072@1|root,arCOG00412@2157|Archaea,41S8M@651137|Thaumarchaeota 651137|Thaumarchaeota J phenylalanyl-tRNA synthetase, beta subunit - - 6.1.1.20 ko:K01890 ko00970,map00970 M00359,M00360 R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - B3_4,B5 k59_916602_1 911008.GLAD_00581 6.23e-18 91.3 COG0582@1|root,COG0582@2|Bacteria,1MX7E@1224|Proteobacteria,1RNX5@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Belongs to the 'phage' integrase family - - - - - - - - - - - - Arm-DNA-bind_1,Phage_int_SAM_1,Phage_integrase k59_916602_4 1280001.BAOA01000078_gene3129 6.12e-05 48.9 COG4566@1|root,COG4566@2|Bacteria,1N6WR@1224|Proteobacteria,1S0TV@1236|Gammaproteobacteria,1XV10@135623|Vibrionales 135623|Vibrionales K helix_turn_helix, Lux Regulon - - - ko:K13041 ko02020,map02020 M00514 - - ko00000,ko00001,ko00002,ko02022 - - - GerE,Response_reg k59_916602_5 31964.pCSL0047 7.42e-72 248.0 COG0433@1|root,COG0433@2|Bacteria,2GKVW@201174|Actinobacteria,4FMH2@85023|Microbacteriaceae 201174|Actinobacteria S Domain of unknown function DUF87 - - - ko:K06915 - - - - ko00000 - - - AAA,DUF87,Zot k59_1424799_1 765913.ThidrDRAFT_2505 1.27e-47 166.0 COG0079@1|root,COG0079@2|Bacteria,1MW7I@1224|Proteobacteria,1RP4T@1236|Gammaproteobacteria,1WYBU@135613|Chromatiales 135613|Chromatiales E Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily hisC - 2.6.1.9 ko:K00817 ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230 M00026 R00694,R00734,R03243 RC00006,RC00888 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 k59_1085894_1 1244869.H261_15380 3.83e-29 120.0 COG2831@1|root,COG2831@2|Bacteria,1MWEC@1224|Proteobacteria,2U04Z@28211|Alphaproteobacteria,2JT2T@204441|Rhodospirillales 204441|Rhodospirillales U Haemolysin secretion/activation protein ShlB/FhaC/HecB - - - - - - - - - - - - POTRA_2,ShlB k59_634113_1 702113.PP1Y_AT1753 2.09e-104 324.0 COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,2TR80@28211|Alphaproteobacteria,2K0EB@204457|Sphingomonadales 204457|Sphingomonadales P P-type ATPase - - 3.6.3.4 ko:K01533 - - R00086 RC00002 ko00000,ko01000 3.A.3.5 - - E1-E2_ATPase,HMA,Hydrolase k59_238437_1 1229909.NSED_05765 9.61e-38 131.0 COG1714@1|root,arCOG03633@2157|Archaea,41T5P@651137|Thaumarchaeota 651137|Thaumarchaeota S membrane protein domain - - - - - - - - - - - - RDD k59_1030572_1 1088721.NSU_2645 5.62e-55 187.0 COG2206@1|root,COG2206@2|Bacteria,1MW7F@1224|Proteobacteria,2U4W9@28211|Alphaproteobacteria,2K9S0@204457|Sphingomonadales 204457|Sphingomonadales T Domain of unknown function (DUF3391) - - - - - - - - - - - - DUF3391,HD_5 k59_1482508_1 1122201.AUAZ01000002_gene887 6.57e-17 83.6 COG1638@1|root,COG1638@2|Bacteria,1MVHC@1224|Proteobacteria,1RUFU@1236|Gammaproteobacteria 1236|Gammaproteobacteria G TIGRFAM TRAP dicarboxylate transporter, DctP subunit - - - ko:K11688 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.56.1 - - DctP k59_746848_1 1399115.U719_09425 4.94e-10 62.0 COG1670@1|root,COG1670@2|Bacteria,1V2FI@1239|Firmicutes,4HFU6@91061|Bacilli 91061|Bacilli J COG1670 Acetyltransferases, including N-acetylases of ribosomal proteins - - 2.3.1.128 ko:K03790 - - - - ko00000,ko01000,ko03009 - - - Acetyltransf_3 k59_126080_1 1231185.BAMP01000007_gene4163 4.59e-21 94.0 COG2265@1|root,COG2265@2|Bacteria,1MV3A@1224|Proteobacteria,2TR40@28211|Alphaproteobacteria,43IA6@69277|Phyllobacteriaceae 28211|Alphaproteobacteria J Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family rumA - 2.1.1.190,2.1.1.35 ko:K00557,ko:K03215 - - - - ko00000,ko01000,ko03009,ko03016 - - - tRNA_U5-meth_tr k59_126080_2 1380394.JADL01000012_gene961 2e-17 79.7 COG1189@1|root,COG1189@2|Bacteria,1MWP5@1224|Proteobacteria,2TRW9@28211|Alphaproteobacteria,2JP9D@204441|Rhodospirillales 204441|Rhodospirillales J rRNA methylase tlyA - 2.1.1.226,2.1.1.227 ko:K06442 - - - - ko00000,ko01000,ko03009 - - - FtsJ,S4 k59_746856_1 713587.THITH_13710 5.35e-06 52.0 COG2885@1|root,COG2885@2|Bacteria,1P1AB@1224|Proteobacteria,1RMCQ@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Belongs to the ompA family oprF - - - - - - - - - - - OmpA k59_1312734_1 1122137.AQXF01000006_gene766 1.05e-178 513.0 COG0342@1|root,COG0342@2|Bacteria,1MV5U@1224|Proteobacteria,2TQYG@28211|Alphaproteobacteria 28211|Alphaproteobacteria U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA secD - - ko:K03072,ko:K12257 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 2.A.6.4,3.A.5.2,3.A.5.7 - - SecD_SecF,Sec_GG k59_1312734_2 1122137.AQXF01000006_gene767 5.43e-44 145.0 COG1862@1|root,COG1862@2|Bacteria,1MZT2@1224|Proteobacteria,2UBZ6@28211|Alphaproteobacteria 28211|Alphaproteobacteria U Preprotein translocase subunit (YajC) yajC - - ko:K03210 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2 - - YajC k59_352314_1 1229909.NSED_08400 2.08e-37 145.0 arCOG07561@1|root,arCOG07561@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - TSP_3,VWA k59_804240_1 411479.BACUNI_03970 1.5e-92 286.0 COG3119@1|root,COG3119@2|Bacteria,4NFC9@976|Bacteroidetes,2FMH6@200643|Bacteroidia,4ANFX@815|Bacteroidaceae 976|Bacteroidetes P COG COG3119 Arylsulfatase A and related enzymes - - - - - - - - - - - - DUF4994,Sulfatase k59_1030587_1 159450.NH14_13070 2.79e-91 291.0 COG0188@1|root,COG0188@2|Bacteria,1MURI@1224|Proteobacteria,2VH7P@28216|Betaproteobacteria,1K1BN@119060|Burkholderiaceae 28216|Betaproteobacteria L Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule parC - - ko:K02621 - - - - ko00000,ko01000,ko02048,ko03032,ko03036 - - - DNA_gyraseA_C,DNA_topoisoIV k59_1142481_1 118163.Ple7327_3133 6.79e-53 181.0 COG0530@1|root,COG0530@2|Bacteria,1G1Y9@1117|Cyanobacteria,3VJ8Y@52604|Pleurocapsales 1117|Cyanobacteria P Sodium/calcium exchanger protein ecm27 - - ko:K07301 - - - - ko00000,ko02000 2.A.19.5 - - Na_Ca_ex k59_1199210_1 1232410.KI421424_gene1755 8.74e-47 162.0 COG4881@1|root,COG4881@2|Bacteria,1QXMX@1224|Proteobacteria,43C41@68525|delta/epsilon subdivisions,2WKYD@28221|Deltaproteobacteria,43TBN@69541|Desulfuromonadales 28221|Deltaproteobacteria S Polysulphide reductase, NrfD cbcU - - - - - - - - - - - NrfD k59_804251_1 1122137.AQXF01000001_gene2885 1.33e-41 149.0 COG0767@1|root,COG0767@2|Bacteria,1MVPN@1224|Proteobacteria,2TSGS@28211|Alphaproteobacteria 28211|Alphaproteobacteria Q ABC-type transport system involved in resistance to organic solvents permease component MA20_08115 - - ko:K02066 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - MlaE,STAS,STAS_2 k59_1594607_1 1249627.D779_4078 3.77e-17 81.6 COG0247@1|root,COG0247@2|Bacteria,1MWTK@1224|Proteobacteria,1RPAB@1236|Gammaproteobacteria,1WWXD@135613|Chromatiales 135613|Chromatiales C 4Fe-4S ferredoxin iron-sulfur binding domain protein - - - ko:K11473 ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130 - R00475 RC00042 ko00000,ko00001 - - - CCG,Fer4_17,Fer4_7,Fer4_8 k59_1707297_1 1054213.HMPREF9946_01325 2.92e-83 256.0 COG0685@1|root,COG0685@2|Bacteria,1MUC9@1224|Proteobacteria,2TQZA@28211|Alphaproteobacteria,2JQ95@204441|Rhodospirillales 204441|Rhodospirillales E Methylenetetrahydrofolate reductase metF - 1.5.1.20 ko:K00297 ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,map00670,map00720,map01100,map01120,map01200,map01523 M00377 R01224,R07168 RC00081 ko00000,ko00001,ko00002,ko01000 - - - MTHFR k59_295941_1 1030157.AFMP01000036_gene2602 9.12e-47 162.0 2DM8I@1|root,32646@2|Bacteria,1QWES@1224|Proteobacteria,2UGIC@28211|Alphaproteobacteria,2K301@204457|Sphingomonadales 204457|Sphingomonadales - - - - - - - - - - - - - - - k59_577739_1 1122137.AQXF01000007_gene3553 6.07e-87 268.0 COG0621@1|root,COG0621@2|Bacteria,1MU7N@1224|Proteobacteria,2TQUS@28211|Alphaproteobacteria 28211|Alphaproteobacteria J Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 rimO - 2.8.4.4 ko:K14441 - - R10652 RC00003,RC03217 ko00000,ko01000,ko03009 - - - Radical_SAM,TRAM,UPF0004 k59_1538529_1 522306.CAP2UW1_3042 5.52e-10 65.1 COG1639@1|root,COG2114@1|root,COG1639@2|Bacteria,COG2114@2|Bacteria,1RASR@1224|Proteobacteria,2VR0D@28216|Betaproteobacteria 28216|Betaproteobacteria T HDOD domain - - - - - - - - - - - - HDOD k59_408379_1 1001585.MDS_1454 5.88e-54 177.0 COG4659@1|root,COG4659@2|Bacteria,1RDEP@1224|Proteobacteria,1RPAD@1236|Gammaproteobacteria,1YG63@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria C Part of a membrane complex involved in electron transport rnfG - - ko:K03612 - - - - ko00000 - - - FMN_bind k59_1764147_1 930169.B5T_02211 3.69e-186 533.0 COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,1RMBS@1236|Gammaproteobacteria,1XHWB@135619|Oceanospirillales 135619|Oceanospirillales NU Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB gspE - - ko:K02454 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - T2SSE k59_1764147_2 981223.AIED01000004_gene2935 3.72e-28 113.0 COG1459@1|root,COG1459@2|Bacteria,1MV4U@1224|Proteobacteria,1RQ86@1236|Gammaproteobacteria,3NIVU@468|Moraxellaceae 1236|Gammaproteobacteria U general secretion pathway protein gspF - - ko:K02455 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - T2SSF k59_1538538_1 1120953.AUBH01000001_gene1021 1.9e-64 205.0 COG0668@1|root,COG0668@2|Bacteria,1MZKZ@1224|Proteobacteria,1S6N8@1236|Gammaproteobacteria,466V3@72275|Alteromonadaceae 1236|Gammaproteobacteria M COG0668 Small-conductance mechanosensitive channel - - - - - - - - - - - - MS_channel k59_1424867_1 215803.DB30_2460 2.54e-13 74.3 COG1678@1|root,COG1678@2|Bacteria,1RCXM@1224|Proteobacteria,42SD7@68525|delta/epsilon subdivisions,2WPI5@28221|Deltaproteobacteria,2YVK5@29|Myxococcales 28221|Deltaproteobacteria K Belongs to the UPF0301 (AlgH) family - - - ko:K07735 - - - - ko00000,ko03000 - - - DUF179 k59_1424872_1 1229909.NSED_01255 1.38e-50 162.0 arCOG08784@1|root,arCOG08784@2157|Archaea,41SVZ@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1424872_2 1131266.ARWQ01000032_gene1006 3.05e-41 147.0 arCOG08785@1|root,arCOG08785@2157|Archaea,41SVD@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - ko:K03646 - - - - ko00000,ko02000 2.C.1.2 - - - k59_577759_1 888064.HMPREF9088_0654 1.74e-25 104.0 COG0596@1|root,COG0596@2|Bacteria,1TS4C@1239|Firmicutes,4HB6G@91061|Bacilli,4B5Z9@81852|Enterococcaceae 91061|Bacilli S Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) menH GO:0003674,GO:0003824,GO:0016787 4.2.99.20 ko:K08680 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116 R08166 RC02148,RC02475 ko00000,ko00001,ko00002,ko01000 - - - Abhydrolase_1,Abhydrolase_6 k59_577759_2 926550.CLDAP_30590 5.58e-40 146.0 COG1575@1|root,COG1575@2|Bacteria,2G5ZC@200795|Chloroflexi 200795|Chloroflexi H Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK) menA - 2.5.1.74 ko:K02548 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116 R05617,R06858,R10757 RC02935,RC02936,RC03264 ko00000,ko00001,ko00002,ko01000,ko01006 - - - UbiA k59_1651451_1 1178482.BJB45_04665 2.15e-31 124.0 COG0116@1|root,COG1092@1|root,COG0116@2|Bacteria,COG1092@2|Bacteria,1MUQM@1224|Proteobacteria,1RNMH@1236|Gammaproteobacteria,1XHEH@135619|Oceanospirillales 135619|Oceanospirillales J Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA rlmL - 2.1.1.173,2.1.1.264 ko:K12297 - - R07234 RC00003 ko00000,ko01000,ko03009 - - - Methyltrans_SAM,THUMP,UPF0020 k59_634188_2 1504672.669784304 6.31e-46 173.0 COG2982@1|root,COG2982@2|Bacteria,1MUME@1224|Proteobacteria,2VIKY@28216|Betaproteobacteria 28216|Betaproteobacteria M Domain of Unknown Function (DUF748) - - - - - - - - - - - - DUF748 k59_634191_1 506534.Rhein_1362 1.12e-61 206.0 COG0778@1|root,COG0778@2|Bacteria,1RDTR@1224|Proteobacteria,1S0PS@1236|Gammaproteobacteria,1X18Z@135613|Chromatiales 135613|Chromatiales C Nitroreductase family - - - - - - - - - - - - Nitroreductase k59_182426_1 220664.PFL_2564 1.09e-81 259.0 COG0446@1|root,COG0446@2|Bacteria,1N5MC@1224|Proteobacteria,1RQS1@1236|Gammaproteobacteria,1YM5K@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria S Pyridine nucleotide-disulfide sqrdl - 1.8.5.4 ko:K17218 ko00920,map00920 - R10152 RC03155 ko00000,ko00001,ko01000 - - - DUF442,Pyr_redox_2 k59_1651464_1 105559.Nwat_2722 6.88e-17 80.9 COG0702@1|root,COG0702@2|Bacteria,1MW54@1224|Proteobacteria,1RNS7@1236|Gammaproteobacteria,1WXE7@135613|Chromatiales 135613|Chromatiales GM NAD-dependent epimerase dehydratase - - 1.6.5.3,1.6.99.3 ko:K00329,ko:K00356 ko00190,map00190 - R11945 RC00061 ko00000,ko00001,ko01000 - - - Epimerase,NAD_binding_10 k59_1651464_2 1122164.JHWF01000015_gene1659 9.04e-49 167.0 COG0617@1|root,COG0617@2|Bacteria,1MU2X@1224|Proteobacteria,1RPFJ@1236|Gammaproteobacteria,1JDJA@118969|Legionellales 118969|Legionellales F Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. Also shows phosphatase, 2'- nucleotidase and 2',3'-cyclic phosphodiesterase activities. These phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases cca GO:0003674,GO:0003824,GO:0004652,GO:0004810,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0070566,GO:0071704,GO:0090304,GO:1901360,GO:1990817 2.7.7.72 ko:K00974 ko03013,map03013 - R09382,R09383,R09384,R09386 RC00078 ko00000,ko00001,ko01000,ko03016 - - - HD,PolyA_pol,PolyA_pol_RNAbd k59_746938_2 1122137.AQXF01000001_gene2775 1.53e-121 370.0 COG1752@1|root,COG1752@2|Bacteria,1MWH2@1224|Proteobacteria,2TU16@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Protein of unknown function (DUF3376) - - - - - - - - - - - - DUF3376,Patatin k59_1482600_1 411464.DESPIG_01864 1.2e-24 109.0 COG0507@1|root,COG0507@2|Bacteria,1MW43@1224|Proteobacteria,42M8J@68525|delta/epsilon subdivisions,2WJD6@28221|Deltaproteobacteria,2M9DU@213115|Desulfovibrionales 28221|Deltaproteobacteria L DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity recD2 - 3.1.11.5 ko:K03581 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - AAA_30,HHH_4,HHH_5,UvrD_C_2 k59_126144_1 525903.Taci_0489 1.96e-27 115.0 COG4942@1|root,COG4942@2|Bacteria,3T9S7@508458|Synergistetes 508458|Synergistetes D Peptidase, M23 - - - ko:K21471 - - - - ko00000,ko01000,ko01002,ko01011 - - - Peptidase_M23 k59_520699_1 199310.c0771 2.82e-59 187.0 COG0716@1|root,COG0716@2|Bacteria,1MX7F@1224|Proteobacteria,1RMNT@1236|Gammaproteobacteria,3XMN6@561|Escherichia 1236|Gammaproteobacteria C Low-potential electron donor to a number of redox enzymes fldA GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - ko:K03839 - - - - ko00000 - - - Flavodoxin_1 k59_520699_2 199310.c0772 1.39e-63 195.0 2DB8J@1|root,32TX0@2|Bacteria,1MZBR@1224|Proteobacteria,1S9W6@1236|Gammaproteobacteria,3XPUR@561|Escherichia 1236|Gammaproteobacteria S regulation of nucleic acid-templated transcription ybfE GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0033554,GO:0050896,GO:0051716 - - - - - - - - - - RHH_1 k59_295989_2 1211115.ALIQ01000034_gene1998 9.04e-33 118.0 COG1846@1|root,COG1846@2|Bacteria,1RJNN@1224|Proteobacteria,2U9SQ@28211|Alphaproteobacteria 28211|Alphaproteobacteria K transcriptional regulator - - - - - - - - - - - - MarR,MarR_2 k59_1312807_1 522306.CAP2UW1_3045 3.16e-67 218.0 COG1173@1|root,COG1173@2|Bacteria,1MU26@1224|Proteobacteria,2VHWM@28216|Betaproteobacteria,1KQ4K@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria U COG1173 ABC-type dipeptide oligopeptide nickel transport systems, permease components oppC - - ko:K02034 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1 k59_1424943_2 1463820.JOGW01000008_gene1306 7.97e-199 582.0 COG3459@1|root,COG3459@2|Bacteria 2|Bacteria G carbohydrate binding - - 2.4.1.20 ko:K00702 ko00500,ko01100,map00500,map01100 - R00952 RC00049 ko00000,ko00001,ko01000 - GT36 - Glyco_hydro_36,Glyco_transf_36 k59_972470_1 583355.Caka_1490 1.8e-05 45.8 COG0480@1|root,COG0480@2|Bacteria,46SFV@74201|Verrucomicrobia,3K7PT@414999|Opitutae 2|Bacteria J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome fusA GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0019538,GO:0030312,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044464,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2 k59_972470_2 1307761.L21SP2_3267 5.08e-05 47.0 COG0784@1|root,COG0784@2|Bacteria 2|Bacteria T Response regulator, receiver cheY_3 - - - - - - - - - - - 7TMR-DISM_7TM,DegV,HATPase_c,HisKA,Hpt,Reg_prop,Response_reg k59_1312814_1 1229909.NSED_04220 2.27e-38 133.0 arCOG08684@1|root,arCOG08684@2157|Archaea,41T81@651137|Thaumarchaeota 651137|Thaumarchaeota S COG4618 ABC-type protease lipase transport system, ATPase and permease components - - - - - - - - - - - - - k59_1312814_2 436308.Nmar_1523 6.88e-56 176.0 COG0347@1|root,arCOG02305@2157|Archaea,41TB5@651137|Thaumarchaeota 651137|Thaumarchaeota K Belongs to the P(II) protein family - - - ko:K04751 ko02020,map02020 - - - ko00000,ko00001 - - - P-II k59_861273_1 314285.KT71_18456 9.59e-45 160.0 COG0477@1|root,COG0477@2|Bacteria,1R66J@1224|Proteobacteria,1SKG2@1236|Gammaproteobacteria,1J9PQ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria EGP Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 k59_861273_2 1122137.AQXF01000001_gene2763 4.15e-10 60.5 COG0596@1|root,COG0596@2|Bacteria,1QIT9@1224|Proteobacteria,2U8SV@28211|Alphaproteobacteria 28211|Alphaproteobacteria S hydrolases or acyltransferases (alpha beta hydrolase superfamily) - - - - - - - - - - - - Abhydrolase_1,Abhydrolase_6 k59_302216_5 2113.MCFN_03090 2.06e-11 64.7 COG0484@1|root,COG0484@2|Bacteria,3WSX8@544448|Tenericutes 544448|Tenericutes O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins dnaJ - - ko:K03686,ko:K05516 - - - - ko00000,ko03029,ko03036,ko03110 - - - DnaJ,DnaJ_C,DnaJ_CXXCXGXG k59_1205358_1 1382356.JQMP01000001_gene1157 2.04e-96 298.0 COG1060@1|root,COG1060@2|Bacteria,2GBD4@200795|Chloroflexi,27YV4@189775|Thermomicrobia 189775|Thermomicrobia H Elongator protein 3, MiaB family, Radical SAM - - 2.5.1.77 ko:K11779 ko00680,ko01120,map00680,map01120 M00378 R09396 RC01381,RC03002,RC03007 ko00000,ko00001,ko00002,ko01000 - - - Radical_SAM k59_1600815_1 1121440.AUMA01000002_gene2277 1.73e-09 58.5 COG0607@1|root,COG0607@2|Bacteria,1RM2N@1224|Proteobacteria,43093@68525|delta/epsilon subdivisions,2WVD8@28221|Deltaproteobacteria,2M8VF@213115|Desulfovibrionales 28221|Deltaproteobacteria P Rhodanese Homology Domain - - - - - - - - - - - - Rhodanese k59_583725_1 1121374.KB891576_gene253 4.62e-32 124.0 COG0498@1|root,COG0498@2|Bacteria,1MUWQ@1224|Proteobacteria,1RQ0H@1236|Gammaproteobacteria 1236|Gammaproteobacteria E Threonine synthase thrC GO:0003674,GO:0003824,GO:0004795,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006566,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009088,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016838,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.2.3.1 ko:K01733 ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230 M00018 R01466,R05086 RC00017,RC00526 ko00000,ko00001,ko00002,ko01000 - - iLF82_1304.LF82_2261,iNRG857_1313.NRG857_00025 PALP,Thr_synth_N k59_583725_2 745411.B3C1_16817 7.29e-21 92.4 COG0608@1|root,COG0608@2|Bacteria,1MU1M@1224|Proteobacteria,1RMF4@1236|Gammaproteobacteria,1J5AY@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L COG0608 Single-stranded DNA-specific exonuclease recJ - - ko:K07462 ko03410,ko03430,ko03440,map03410,map03430,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DHH,DHHA1 k59_470835_1 555793.WSK_1257 6.8e-139 394.0 COG0176@1|root,COG0176@2|Bacteria,1MWQ8@1224|Proteobacteria,2TQJB@28211|Alphaproteobacteria,2K0F2@204457|Sphingomonadales 204457|Sphingomonadales G Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway tal - 2.2.1.2 ko:K00616 ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007 R01827 RC00439,RC00604 ko00000,ko00001,ko00002,ko01000 - - - TAL_FSA k59_696870_1 392499.Swit_3271 6.38e-85 269.0 COG0129@1|root,COG0129@2|Bacteria,1MUTQ@1224|Proteobacteria,2TRTQ@28211|Alphaproteobacteria,2K026@204457|Sphingomonadales 204457|Sphingomonadales EG Belongs to the IlvD Edd family ilvD - 4.2.1.9 ko:K01687 ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R01209,R04441,R05070 RC00468,RC01714 ko00000,ko00001,ko00002,ko01000 - - - ILVD_EDD k59_76529_1 1123518.ARWI01000001_gene1641 1.68e-55 187.0 COG2132@1|root,COG2132@2|Bacteria,1R89G@1224|Proteobacteria,1S5X0@1236|Gammaproteobacteria 1236|Gammaproteobacteria Q Multicopper oxidase - - - - - - - - - - - - Cu-oxidase,Cu-oxidase_3 k59_810482_1 13690.CP98_04835 6.76e-107 322.0 COG1271@1|root,COG1271@2|Bacteria,1MV60@1224|Proteobacteria,2TQMA@28211|Alphaproteobacteria,2K0ZR@204457|Sphingomonadales 204457|Sphingomonadales C oxidase, subunit cydA - 1.10.3.14 ko:K00425 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00153 R11325 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.4.3 - - Cyt_bd_oxida_I k59_76538_1 1168065.DOK_07639 4.31e-94 293.0 COG4770@1|root,COG4770@2|Bacteria,1P6RE@1224|Proteobacteria,1RM95@1236|Gammaproteobacteria,1J4GW@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria I COG4770 Acetyl propionyl-CoA carboxylase, alpha subunit mccA - 6.4.1.4 ko:K01968 ko00280,ko01100,map00280,map01100 M00036 R04138 RC00367,RC00942 ko00000,ko00001,ko00002,ko01000 - - - Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2 k59_1713723_1 1121090.KB894711_gene4315 1.41e-58 202.0 COG0145@1|root,COG0145@2|Bacteria,1TQVB@1239|Firmicutes,4HB8X@91061|Bacilli,1ZAQW@1386|Bacillus 91061|Bacilli EQ COG0145 N-methylhydantoinase A acetone carboxylase, beta subunit - - 3.5.2.14 ko:K01473 ko00330,ko01100,map00330,map01100 - R03187 RC00632 ko00000,ko00001,ko01000 - - - Hydant_A_N,Hydantoinase_A k59_1148594_1 1111069.TCCBUS3UF1_16190 8.44e-26 110.0 COG0312@1|root,COG0312@2|Bacteria,1WIK5@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus S modulator of DNA gyrase tldD - - ko:K03568 - - - - ko00000,ko01002 - - - PmbA_TldD k59_1488583_1 1122194.AUHU01000006_gene648 1.64e-43 153.0 COG2269@1|root,COG2269@2|Bacteria,1MU97@1224|Proteobacteria,1RMR9@1236|Gammaproteobacteria,4645R@72275|Alteromonadaceae 1236|Gammaproteobacteria J COG2269 Truncated, possibly inactive, lysyl-tRNA synthetase (class II) epmA GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006430,GO:0006464,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016746,GO:0016755,GO:0018193,GO:0018205,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0036211,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0052868,GO:0071704,GO:0071915,GO:0072580,GO:0072581,GO:0090304,GO:0140096,GO:1901360,GO:1901564,GO:1901566,GO:1901576 - ko:K04568 - - - - ko00000,ko01000,ko03012 - - - tRNA-synt_2 k59_1092256_1 994573.T472_0202715 1.67e-27 115.0 COG0474@1|root,COG0474@2|Bacteria,1TPF5@1239|Firmicutes,247JN@186801|Clostridia,36DDM@31979|Clostridiaceae 1239|Firmicutes P ATPase, P-type (transporting), HAD superfamily, subfamily IC - - 3.6.3.8 ko:K01537 - - - - ko00000,ko01000 3.A.3.2 - - Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3 k59_1658040_2 1229909.NSED_09130 1.14e-124 363.0 COG1522@1|root,arCOG01586@2157|Archaea,41T3N@651137|Thaumarchaeota 651137|Thaumarchaeota K AsnC-type helix-turn-helix domain - - - - - - - - - - - - HTH_24 k59_810504_1 1064537.AGSO01000006_gene1839 7.85e-15 80.5 COG1012@1|root,COG1012@2|Bacteria,2GIWZ@201174|Actinobacteria,4FBPN@85020|Dermabacteraceae 201174|Actinobacteria C Aldehyde dehydrogenase family gabD - 1.2.1.16,1.2.1.20,1.2.1.79 ko:K00135 ko00250,ko00310,ko00350,ko00650,ko00760,ko01100,ko01120,map00250,map00310,map00350,map00650,map00760,map01100,map01120 M00027 R00713,R00714,R02401 RC00080 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_1037060_1 1122137.AQXF01000002_gene604 3.18e-102 316.0 COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,2TQNY@28211|Alphaproteobacteria 28211|Alphaproteobacteria KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance spoT - 2.7.6.5,3.1.7.2 ko:K00951,ko:K01139 ko00230,map00230 - R00336,R00429 RC00002,RC00078 ko00000,ko00001,ko01000,ko03009 - - - ACT_4,HD_4,RelA_SpoT,TGS k59_867311_1 596323.HMPREF0554_0501 3.47e-62 207.0 COG0162@1|root,COG0162@2|Bacteria,378M9@32066|Fusobacteria 32066|Fusobacteria J Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) tyrS GO:0003674,GO:0003824,GO:0004812,GO:0004831,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016875,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564 6.1.1.1 ko:K01866 ko00970,map00970 M00359,M00360 R02918 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - S4,tRNA-synt_1b k59_1261623_1 1209072.ALBT01000029_gene2193 3.01e-62 213.0 28I5V@1|root,2Z891@2|Bacteria,1R94B@1224|Proteobacteria,1RWCK@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Cellulase N-terminal ig-like domain - - - - - - - - - - - - CelD_N,Glyco_hydro_9 k59_1205417_1 667014.Thein_0626 2.68e-17 88.2 COG0612@1|root,COG0612@2|Bacteria,2GH66@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria S Belongs to the peptidase M16 family - - - ko:K07263 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M16,Peptidase_M16_C k59_1318798_1 1144343.PMI41_02060 3.25e-85 280.0 COG0506@1|root,COG4230@1|root,COG0506@2|Bacteria,COG4230@2|Bacteria,1MV93@1224|Proteobacteria,2TQPT@28211|Alphaproteobacteria,43ITV@69277|Phyllobacteriaceae 28211|Alphaproteobacteria CE Oxidizes proline to glutamate for use as a carbon and nitrogen source putA - 1.2.1.88,1.5.5.2 ko:K13821 ko00250,ko00330,ko01100,ko01110,ko01130,map00250,map00330,map01100,map01110,map01130 - R00245,R00707,R00708,R01253,R04444,R04445,R05051 RC00080,RC00083,RC00216,RC00242,RC00255 ko00000,ko00001,ko01000,ko03000 - - - Aldedh,Pro_dh,Pro_dh-DNA_bdg k59_19243_1 1379270.AUXF01000001_gene2785 4.12e-54 191.0 COG0612@1|root,COG0612@2|Bacteria,1ZSU0@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Insulinase (Peptidase family M16) - - - ko:K07263 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M16,Peptidase_M16_C k59_810533_1 1232410.KI421421_gene3584 4.64e-52 171.0 COG1778@1|root,COG1778@2|Bacteria,1RH85@1224|Proteobacteria,42SN2@68525|delta/epsilon subdivisions,2WP0X@28221|Deltaproteobacteria,43SHS@69541|Desulfuromonadales 28221|Deltaproteobacteria S 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase kdsC - 3.1.3.45 ko:K03270 ko00540,ko01100,map00540,map01100 M00063 R03350 RC00017 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Hydrolase_3 k59_76585_2 861299.J421_3934 1.15e-54 182.0 COG1960@1|root,COG1960@2|Bacteria,1ZSVE@142182|Gemmatimonadetes 142182|Gemmatimonadetes I Acyl-CoA dehydrogenase, C-terminal domain - - 1.3.8.6 ko:K00252 ko00071,ko00310,ko00362,ko00380,ko01100,ko01120,ko01130,map00071,map00310,map00362,map00380,map01100,map01120,map01130 M00032 R02487,R02488,R10074 RC00052,RC00156 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_978515_1 436308.Nmar_1667 9.71e-158 452.0 COG2132@1|root,arCOG03914@2157|Archaea,41SZT@651137|Thaumarchaeota 651137|Thaumarchaeota Q Multicopper oxidase - - 1.7.2.1 ko:K00368 ko00910,ko01120,map00910,map01120 M00529 R00783,R00785 RC00086 ko00000,ko00001,ko00002,ko01000 - - - Cu-oxidase_3 k59_470906_1 511051.CSE_07160 6e-21 91.7 COG0074@1|root,COG0074@2|Bacteria 2|Bacteria C Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit sucD - 6.2.1.5 ko:K01902,ko:K02381 ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374,M00620 R00405,R02404 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000 - - - CoA_binding,DUF1116,Ligase_CoA k59_470906_2 1288963.ADIS_4742 5.39e-11 63.2 2B1XW@1|root,31UE7@2|Bacteria,4NY8Q@976|Bacteroidetes,47W4P@768503|Cytophagia 976|Bacteroidetes S 23S rRNA-intervening sequence protein - - - - - - - - - - - - 23S_rRNA_IVP k59_302274_1 287986.DV20_37930 4.74e-61 218.0 COG4805@1|root,COG4805@2|Bacteria,2GMUR@201174|Actinobacteria,4DZQU@85010|Pseudonocardiales 201174|Actinobacteria S Bacterial protein of unknown function (DUF885) - - - - - - - - - - - - DUF885 k59_923041_1 571166.KI421509_gene1121 3.98e-27 114.0 COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,2TQMW@28211|Alphaproteobacteria 28211|Alphaproteobacteria C COG1529 Aerobic-type carbon monoxide dehydrogenase large subunit CoxL CutL homologs coxL - 1.2.5.3 ko:K03520 - - R11168 RC02800 ko00000,ko01000 - - - Ald_Xan_dh_C,Ald_Xan_dh_C2 k59_640648_2 545694.TREPR_0214 1.83e-05 51.6 COG5340@1|root,COG5340@2|Bacteria,2J8AW@203691|Spirochaetes 203691|Spirochaetes K Transcriptional regulator, AbiEi antitoxin - - - - - - - - - - - - - k59_923047_2 1276756.AUEX01000015_gene1940 3.3e-44 150.0 COG0605@1|root,COG0605@2|Bacteria,1MVW2@1224|Proteobacteria,2VI2Y@28216|Betaproteobacteria,4AAFF@80864|Comamonadaceae 28216|Betaproteobacteria C Destroys radicals which are normally produced within the cells and which are toxic to biological systems sodB GO:0000302,GO:0000303,GO:0000305,GO:0003674,GO:0003824,GO:0004784,GO:0006801,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0010035,GO:0016209,GO:0016491,GO:0016721,GO:0019430,GO:0033554,GO:0034599,GO:0034614,GO:0042221,GO:0044237,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0071450,GO:0071451,GO:0072593,GO:0097237,GO:0098754,GO:0098869,GO:1901700,GO:1901701,GO:1990748 1.15.1.1,3.1.11.6 ko:K03601,ko:K04564 ko03430,ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map03430,map04013,map04068,map04146,map04211,map04212,map04213,map05016 - - - ko00000,ko00001,ko01000,ko03400 - - - Sod_Fe_C,Sod_Fe_N k59_1544734_1 1229203.KI301992_gene427 8.15e-15 81.3 COG0210@1|root,COG2887@1|root,COG0210@2|Bacteria,COG2887@2|Bacteria,2GM2E@201174|Actinobacteria,3UWE8@52018|unclassified Actinobacteria (class) 201174|Actinobacteria L PD-(D/E)XK nuclease superfamily uvrD2 - 3.6.4.12 ko:K03657 ko03420,ko03430,map03420,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - PDDEXK_1,UvrD-helicase,UvrD_C k59_1600892_1 1120946.AUBF01000004_gene1715 1.16e-09 61.6 COG1022@1|root,COG1022@2|Bacteria,2GIXQ@201174|Actinobacteria,4D41S@85005|Actinomycetales 201174|Actinobacteria I AMP-binding enzyme fadD3 - 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding k59_1600892_2 383372.Rcas_0396 9.61e-101 298.0 COG0346@1|root,COG0346@2|Bacteria,2G80H@200795|Chloroflexi 200795|Chloroflexi E lactoylglutathione lyase activity - - 4.2.1.96 ko:K01724 ko00790,map00790 - R04734 RC01208 ko00000,ko00001,ko01000,ko04147 - - - - k59_1544737_2 626887.J057_23155 1.09e-25 103.0 COG0451@1|root,COG0451@2|Bacteria,1MU7J@1224|Proteobacteria,1RPTA@1236|Gammaproteobacteria,464JQ@72275|Alteromonadaceae 1236|Gammaproteobacteria M COG0451 Nucleoside-diphosphate-sugar epimerases capI - 5.1.3.25,5.1.3.6 ko:K08679,ko:K17947 ko00520,ko00523,ko01100,ko01130,map00520,map00523,map01100,map01130 - R01385,R10279 RC00289 ko00000,ko00001,ko01000 - - - Epimerase,GDP_Man_Dehyd k59_244799_1 1035839.AFNK01000035_gene1154 1.47e-12 68.2 COG0628@1|root,COG0628@2|Bacteria,1MXXU@1224|Proteobacteria,1RQCM@1236|Gammaproteobacteria,1Y7SV@135625|Pasteurellales 135625|Pasteurellales S UPF0118 membrane protein tqsA GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944 - - - - - - - - - - AI-2E_transport k59_244799_2 55601.VANGNB10_cI0654c 1.2e-25 100.0 COG0517@1|root,COG0517@2|Bacteria,1N0EB@1224|Proteobacteria,1S9TG@1236|Gammaproteobacteria,1XX1F@135623|Vibrionales 135623|Vibrionales S acetoin utilization protein - - - - - - - - - - - - CBS k59_696962_1 1096930.L284_20475 1.45e-112 348.0 COG0188@1|root,COG0188@2|Bacteria,1MUGG@1224|Proteobacteria,2TSPQ@28211|Alphaproteobacteria,2K02J@204457|Sphingomonadales 204457|Sphingomonadales L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrA - 5.99.1.3 ko:K02469 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseA_C,DNA_topoisoIV k59_1037111_1 1333998.M2A_0424 1.29e-80 246.0 COG0625@1|root,COG0625@2|Bacteria,1Q05U@1224|Proteobacteria,2TTDK@28211|Alphaproteobacteria 28211|Alphaproteobacteria O Glutathione S-transferase - - - - - - - - - - - - GST_C,GST_C_2,GST_N,GST_N_3 k59_1544748_1 216594.MMAR_0552 2.5e-26 113.0 COG1073@1|root,COG1073@2|Bacteria,2GVYQ@201174|Actinobacteria,2331G@1762|Mycobacteriaceae 201174|Actinobacteria S alpha beta - - - - - - - - - - - - Abhydrolase_1,Peptidase_S9 k59_753405_1 1035308.AQYY01000001_gene3036 2.24e-23 104.0 COG2378@1|root,COG2378@2|Bacteria 2|Bacteria K regulation of single-species biofilm formation pafB - - ko:K13572 - - - - ko00000,ko03051 - - - WYL k59_1770419_1 1313172.YM304_36520 8.18e-69 220.0 COG2141@1|root,COG2141@2|Bacteria,2GJTP@201174|Actinobacteria 201174|Actinobacteria C F420-dependent oxidoreductase - - - - - - - - - - - - Bac_luciferase k59_76627_2 1500259.JQLD01000010_gene4812 7.65e-31 119.0 COG0600@1|root,COG0600@2|Bacteria,1N4HG@1224|Proteobacteria,2TSTU@28211|Alphaproteobacteria,4BBHM@82115|Rhizobiaceae 28211|Alphaproteobacteria P Binding-protein-dependent transport system inner membrane component - - - ko:K02050 - M00188 - - ko00000,ko00002,ko02000 3.A.1.16,3.A.1.17 - - BPD_transp_1 k59_867365_1 1121035.AUCH01000003_gene1236 1.17e-38 143.0 COG0773@1|root,COG0773@2|Bacteria,1MUC5@1224|Proteobacteria,2VIX5@28216|Betaproteobacteria,2KUZ4@206389|Rhodocyclales 206389|Rhodocyclales M Reutilizes the intact tripeptide L-alanyl-gamma-D- glutamyl-meso-diaminopimelate by linking it to UDP-N- acetylmuramate mpl - 6.3.2.45 ko:K02558 - - - - ko00000,ko01000 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_1488657_1 1122137.AQXF01000006_gene775 5.12e-74 228.0 COG1386@1|root,COG1386@2|Bacteria,1PUA6@1224|Proteobacteria,2TU64@28211|Alphaproteobacteria 28211|Alphaproteobacteria D Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves scpB - - ko:K06024 - - - - ko00000,ko03036 - - - SMC_ScpB k59_1488657_2 1122137.AQXF01000006_gene776 3.15e-146 417.0 COG1354@1|root,COG1354@2|Bacteria,1MVCN@1224|Proteobacteria,2TS1V@28211|Alphaproteobacteria 28211|Alphaproteobacteria D Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves scpA - - ko:K05896 - - - - ko00000,ko03036 - - - SMC_ScpA k59_1488657_3 1122137.AQXF01000006_gene777 5.41e-23 93.6 COG1994@1|root,COG1994@2|Bacteria,1NSFF@1224|Proteobacteria,2TRIF@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Peptidase M50 MA20_27160 - - - - - - - - - - - Peptidase_M50 k59_1770422_1 1249627.D779_0883 2.43e-110 332.0 COG0053@1|root,COG0053@2|Bacteria,1MUDS@1224|Proteobacteria,1RNS2@1236|Gammaproteobacteria,1WX2U@135613|Chromatiales 135613|Chromatiales P Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family - - - - - - - - - - - - Cation_efflux,ZT_dimer k59_414390_1 1229909.NSED_06960 3.62e-22 90.5 arCOG08716@1|root,arCOG08716@2157|Archaea 1229909.NSED_06960|- - - - - - - - - - - - - - - - k59_414390_2 1229909.NSED_06950 1.08e-130 376.0 COG1712@1|root,arCOG00254@2157|Archaea,41SGA@651137|Thaumarchaeota 651137|Thaumarchaeota H Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate nadX - 1.4.1.21 ko:K06989 ko00760,ko01100,map00760,map01100 - R07407,R07410 RC02566 ko00000,ko00001,ko01000 - - - DUF108,NAD_binding_3 k59_753424_1 267608.RSc2458 1.4e-25 106.0 COG0060@1|root,COG0060@2|Bacteria,1MVBQ@1224|Proteobacteria,2VIEJ@28216|Betaproteobacteria,1K19S@119060|Burkholderiaceae 28216|Betaproteobacteria J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) ileS - 6.1.1.5 ko:K01870 ko00970,map00970 M00359,M00360 R03656 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,tRNA-synt_1,zf-FPG_IleRS k59_1600937_1 1380394.JADL01000004_gene6060 1.69e-55 193.0 COG4231@1|root,COG4231@2|Bacteria,1MUKS@1224|Proteobacteria,2TSHH@28211|Alphaproteobacteria,2JSZE@204441|Rhodospirillales 204441|Rhodospirillales C Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates - - - - - - - - - - - - TPP_enzyme_C k59_19295_1 1385515.N791_04110 6.07e-34 124.0 COG3028@1|root,COG3028@2|Bacteria,1MZ4R@1224|Proteobacteria,1S9JJ@1236|Gammaproteobacteria,1X636@135614|Xanthomonadales 135614|Xanthomonadales S Belongs to the UPF0307 family - - - ko:K09889 - - - - ko00000,ko03009 - - - DUF615 k59_1544772_1 402881.Plav_2304 9.43e-58 189.0 28KEA@1|root,2ZA0J@2|Bacteria,1R5TS@1224|Proteobacteria,2U48U@28211|Alphaproteobacteria,1JPR2@119043|Rhodobiaceae 28211|Alphaproteobacteria H Sulfotransferase domain - - 2.8.2.1 ko:K01014 ko05204,map05204 - R01242 RC00007,RC00128 ko00000,ko00001,ko01000 - - - Sulfotransfer_1 k59_867397_1 436308.Nmar_0397 9.95e-94 281.0 COG0448@1|root,arCOG00912@2157|Archaea,41SEY@651137|Thaumarchaeota 651137|Thaumarchaeota E aspartate ornithine carbamoyltransferase carbamoyl-P binding domain - - 2.1.3.3 ko:K00611 ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230 M00029,M00844 R01398 RC00096 ko00000,ko00001,ko00002,ko01000 - - - OTCace,OTCace_N k59_867397_2 436308.Nmar_0396 3.13e-15 77.0 COG0552@1|root,arCOG01227@2157|Archaea,41SCC@651137|Thaumarchaeota 651137|Thaumarchaeota U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) ftsY - - ko:K03110 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2,3.A.5.7 - - SRP54,SRP54_N k59_132194_1 1229909.NSED_06105 1.47e-102 313.0 COG1793@1|root,arCOG01347@2157|Archaea,41SCK@651137|Thaumarchaeota 651137|Thaumarchaeota L DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair lig - 6.5.1.1,6.5.1.6,6.5.1.7 ko:K10747 ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430 - R00381,R00382,R10822,R10823 RC00005 ko00000,ko00001,ko01000,ko03032,ko03400 - - - DNA_ligase_A_C,DNA_ligase_A_M,DNA_ligase_A_N k59_470961_1 288000.BBta_5357 3.27e-103 316.0 COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,2TRNK@28211|Alphaproteobacteria,3JVXA@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins - - - ko:K03798 - M00742 - - ko00000,ko00002,ko01000,ko01002,ko03110 - - - AAA,FtsH_ext,Peptidase_M41 k59_470965_1 1379698.RBG1_1C00001G0499 4.22e-17 82.4 COG0810@1|root,COG0810@2|Bacteria,2NQ3G@2323|unclassified Bacteria 2|Bacteria M TonB C terminal - - - ko:K03646,ko:K03832 - - - - ko00000,ko02000 2.C.1.1,2.C.1.2 - - CarbopepD_reg_2,TonB_2,TonB_C k59_583864_1 330214.NIDE2516 4.48e-96 291.0 COG0006@1|root,COG0006@2|Bacteria,3J0R0@40117|Nitrospirae 40117|Nitrospirae E Metallopeptidase family M24 - - 3.4.11.9 ko:K01262 - - - - ko00000,ko01000,ko01002 - - - Creatinase_N,Peptidase_M24 k59_1092370_1 404589.Anae109_3014 5.67e-06 51.2 2CNUX@1|root,32SHU@2|Bacteria,1REYT@1224|Proteobacteria,42R1S@68525|delta/epsilon subdivisions,2WMRC@28221|Deltaproteobacteria,2YVEV@29|Myxococcales 28221|Deltaproteobacteria S Domain of unknown function (DUF2760) - - - - - - - - - - - - DUF2760 k59_1092370_2 338963.Pcar_2862 7.4e-14 68.2 COG3089@1|root,COG3089@2|Bacteria,1Q2IH@1224|Proteobacteria,42VSF@68525|delta/epsilon subdivisions,2WRZS@28221|Deltaproteobacteria,43SS8@69541|Desulfuromonadales 28221|Deltaproteobacteria S Uncharacterised protein family (UPF0270) - - - ko:K09898 - - - - ko00000 - - - UPF0270 k59_1092370_3 1121939.L861_08685 5.13e-14 70.5 COG0026@1|root,COG0026@2|Bacteria,1MVHP@1224|Proteobacteria,1RSAE@1236|Gammaproteobacteria,1XHME@135619|Oceanospirillales 135619|Oceanospirillales F Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) - - - - - - - - - - - - - k59_979544_1 1123503.KB908056_gene1880 1.98e-07 51.2 COG0789@1|root,COG0789@2|Bacteria,1N0AZ@1224|Proteobacteria,2UD14@28211|Alphaproteobacteria,2KK32@204458|Caulobacterales 204458|Caulobacterales K helix_turn_helix, mercury resistance - - - - - - - - - - - - - k59_979544_2 670292.JH26_05880 3.73e-41 143.0 297W1@1|root,2ZV2M@2|Bacteria,1QN4J@1224|Proteobacteria,2U80H@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Domain of unknown function (DUF4396) - - - - - - - - - - - - DUF4396 k59_1771277_1 582402.Hbal_2757 9.66e-156 442.0 COG0179@1|root,COG0179@2|Bacteria,1MUPF@1224|Proteobacteria,2TQQG@28211|Alphaproteobacteria,43XGZ@69657|Hyphomonadaceae 28211|Alphaproteobacteria Q COG0179 2-keto-4-pentenoate hydratase 2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) - - - ko:K18336 ko00051,ko01120,map00051,map01120 - R10691 RC00326,RC03236 ko00000,ko00001,ko01000 - - - FAA_hydrolase k59_1771277_2 1159870.KB907784_gene2509 4.07e-08 53.9 COG4948@1|root,COG4948@2|Bacteria,1MW5B@1224|Proteobacteria,2VK18@28216|Betaproteobacteria,3T4C7@506|Alcaligenaceae 28216|Betaproteobacteria M Belongs to the mandelate racemase muconate lactonizing enzyme family - - 5.5.1.1 ko:K01856 ko00361,ko00362,ko00364,ko00623,ko01100,ko01120,ko01220,map00361,map00362,map00364,map00623,map01100,map01120,map01220 M00568 R05300,R05390,R06989,R08116,R09229 RC00903,RC01038,RC01108,RC01321,RC01356 ko00000,ko00001,ko00002,ko01000 - - - MR_MLE_C,MR_MLE_N k59_1432123_1 1144305.PMI02_05396 3.52e-84 256.0 COG0602@1|root,COG0602@2|Bacteria,1MUJ2@1224|Proteobacteria,2TU1S@28211|Alphaproteobacteria,2K21H@204457|Sphingomonadales 204457|Sphingomonadales H Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds queE - 4.3.99.3 ko:K10026 ko00790,ko01100,map00790,map01100 - R10002 RC02989 ko00000,ko00001,ko01000,ko03016 - - - Fer4_14,Radical_SAM k59_303468_1 1157708.KB907450_gene5812 4.34e-44 154.0 2A20V@1|root,30QAU@2|Bacteria,1RDQH@1224|Proteobacteria,2VQZV@28216|Betaproteobacteria,4ADSI@80864|Comamonadaceae 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_868666_1 1278309.KB907108_gene1549 4.41e-53 191.0 COG0771@1|root,COG2931@1|root,COG0771@2|Bacteria,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,1RNK8@1236|Gammaproteobacteria 1236|Gammaproteobacteria Q COG2931 RTX toxins and related Ca2 -binding proteins - - - - - - - - - - - - DUF4347 k59_754351_1 1122137.AQXF01000003_gene1924 2.64e-94 288.0 COG0055@1|root,COG0055@2|Bacteria,1MUFU@1224|Proteobacteria,2TRGP@28211|Alphaproteobacteria 28211|Alphaproteobacteria C Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits atpD - 3.6.3.14 ko:K02112 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - - ATP-synt_ab,ATP-synt_ab_N k59_754351_2 1121033.AUCF01000008_gene5634 3.97e-11 62.0 COG0224@1|root,COG0224@2|Bacteria,1MU28@1224|Proteobacteria,2TR11@28211|Alphaproteobacteria,2JQGC@204441|Rhodospirillales 204441|Rhodospirillales C Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex atpG - - ko:K02115 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt k59_527765_1 330214.NIDE2751 2.9e-50 162.0 COG1259@1|root,COG1259@2|Bacteria,3J0RC@40117|Nitrospirae 40117|Nitrospirae S Bifunctional nuclease - - - ko:K08999 - - - - ko00000 - - - DNase-RNase k59_527765_2 330214.NIDE2750 6.47e-21 84.3 COG2924@1|root,COG2924@2|Bacteria,3J1CU@40117|Nitrospirae 40117|Nitrospirae C Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes - - - - - - - - - - - - Iron_traffic k59_360052_1 1125863.JAFN01000001_gene2409 1.54e-134 396.0 COG1008@1|root,COG1008@2|Bacteria,1MV7V@1224|Proteobacteria,42NGD@68525|delta/epsilon subdivisions,2WJDC@28221|Deltaproteobacteria 28221|Deltaproteobacteria C TIGRFAM proton-translocating NADH-quinone oxidoreductase, chain M nuoM-1 - 1.6.5.3 ko:K00342 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q5_N,Proton_antipo_M k59_585104_1 1131462.DCF50_p2770 5.56e-05 52.0 COG0784@1|root,COG2206@1|root,COG0784@2|Bacteria,COG2206@2|Bacteria,1UZN2@1239|Firmicutes,248SE@186801|Clostridia,26242@186807|Peptococcaceae 186801|Clostridia T metal-dependent phosphohydrolase, HD sub domain - - - - - - - - - - - - DUF3369,GAF,GAF_2,HAMP,HD,HD_5,PAS_9,Response_reg k59_1609135_7 1158150.KB906242_gene236 4.54e-29 115.0 COG0270@1|root,COG0270@2|Bacteria,1R6IB@1224|Proteobacteria,1SQ0T@1236|Gammaproteobacteria 1236|Gammaproteobacteria L DNA (cytosine-5-)-methyltransferase activity - - - - - - - - - - - - - k59_1609135_8 1121896.JMLU01000052_gene1260 2.48e-31 126.0 2BFD6@1|root,3296M@2|Bacteria,4NQWY@976|Bacteroidetes,1I31C@117743|Flavobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_366981_1 1000565.METUNv1_03331 2.66e-33 121.0 COG1917@1|root,COG1917@2|Bacteria,1MZF9@1224|Proteobacteria,2VSHI@28216|Betaproteobacteria 28216|Betaproteobacteria S Cupin 2, conserved barrel domain protein - - - - - - - - - - - - Cupin_1,Cupin_2,DUF4437 k59_366981_2 216142.LT40_12690 0.000115 45.4 COG1063@1|root,COG1063@2|Bacteria,1MW6Y@1224|Proteobacteria,1RRPT@1236|Gammaproteobacteria 1236|Gammaproteobacteria E COG1063 Threonine dehydrogenase and related Zn-dependent dehydrogenases ybdR - - - - - - - - - - - ADH_N,ADH_N_assoc,ADH_zinc_N k59_1098584_1 626887.J057_04996 1.99e-68 233.0 COG1752@1|root,COG4775@1|root,COG1752@2|Bacteria,COG4775@2|Bacteria,1MUM9@1224|Proteobacteria,1RRSK@1236|Gammaproteobacteria,468GY@72275|Alteromonadaceae 1236|Gammaproteobacteria M esterase of the alpha-beta hydrolase superfamily plpD - - ko:K07001 - - - - ko00000 - - - Bac_surface_Ag,POTRA,Patatin k59_1155574_1 380703.AHA_0548 4.45e-38 148.0 COG0025@1|root,COG1226@1|root,COG0025@2|Bacteria,COG1226@2|Bacteria,1QTUE@1224|Proteobacteria,1T1HJ@1236|Gammaproteobacteria,1Y6MG@135624|Aeromonadales 135624|Aeromonadales P Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family - - - - - - - - - - - - Na_H_Exchanger,TrkA_N k59_1775292_1 1128421.JAGA01000003_gene3361 1.56e-41 148.0 COG0834@1|root,COG0834@2|Bacteria,2NQ40@2323|unclassified Bacteria 2|Bacteria ET Bacterial periplasmic substrate-binding proteins - - - ko:K02030 - M00236 - - ko00000,ko00002,ko02000 3.A.1.3 - - SBP_bac_3 k59_252305_1 298654.FraEuI1c_1947 6.75e-61 208.0 COG2227@1|root,COG2227@2|Bacteria,2GNRH@201174|Actinobacteria,4ETID@85013|Frankiales 201174|Actinobacteria H PFAM methyltransferase - - - - - - - - - - - - Methyltransf_23 k59_1324458_1 1000565.METUNv1_04051 7.99e-38 134.0 COG1526@1|root,COG1526@2|Bacteria,1MY28@1224|Proteobacteria,2VK94@28216|Betaproteobacteria,2KV23@206389|Rhodocyclales 206389|Rhodocyclales C Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH fdhD - - ko:K02379 - - - - ko00000 - - - FdhD-NarQ k59_1324458_2 1348657.M622_06565 7.58e-100 300.0 COG2896@1|root,COG2896@2|Bacteria,1MW3W@1224|Proteobacteria,2VHW4@28216|Betaproteobacteria,2KURW@206389|Rhodocyclales 206389|Rhodocyclales H Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate moaA - 4.1.99.22 ko:K03639 ko00790,ko01100,ko04122,map00790,map01100,map04122 - R09394 RC03420 ko00000,ko00001,ko01000 - - - Fer4_12,Fer4_14,Mob_synth_C,Radical_SAM k59_875296_1 497321.C664_09813 3.8e-108 321.0 COG2010@1|root,COG2010@2|Bacteria,1MUCW@1224|Proteobacteria,2VHGS@28216|Betaproteobacteria,2KUZH@206389|Rhodocyclales 206389|Rhodocyclales C C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex ccoP - - ko:K00406 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00156 - - ko00000,ko00001,ko00002 3.D.4.3 - - Cytochrome_CBB3,FixP_N k59_1267678_1 1088721.NSU_4025 5.88e-45 162.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,2TQQE@28211|Alphaproteobacteria,2K2U5@204457|Sphingomonadales 204457|Sphingomonadales NT chemotaxis protein - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - MCPsignal k59_252315_2 1122939.ATUD01000003_gene3610 0.00026 42.4 COG1335@1|root,COG1488@1|root,COG1335@2|Bacteria,COG1488@2|Bacteria,2GJAT@201174|Actinobacteria,4CQTG@84995|Rubrobacteria 84995|Rubrobacteria H Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP - - 6.3.4.21 ko:K00763 ko00760,ko01100,map00760,map01100 - R01724 RC00033 ko00000,ko00001,ko01000 - - - Isochorismatase,QRPTase_C,QRPTase_N k59_875302_1 1423806.JCM15457_1360 2.53e-21 92.8 COG0022@1|root,COG0022@2|Bacteria,1TP3J@1239|Firmicutes,4HAP6@91061|Bacilli,3F96J@33958|Lactobacillaceae 91061|Bacilli C Transketolase, pyrimidine binding domain acoB - - ko:K21417 - - - - ko00000,ko01000 - - - Transket_pyr,Transketolase_C k59_875302_2 1122137.AQXF01000004_gene1440 6.59e-21 93.2 COG1071@1|root,COG1071@2|Bacteria,1MU5R@1224|Proteobacteria,2UQUA@28211|Alphaproteobacteria 28211|Alphaproteobacteria C Dehydrogenase E1 component - - - ko:K21416 - - - - ko00000,ko01000 - - - E1_dh k59_758943_1 1163617.SCD_n00511 3.3e-85 272.0 COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,2VIA1@28216|Betaproteobacteria 28216|Betaproteobacteria KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance spoT - 2.7.6.5,3.1.7.2 ko:K01139 ko00230,map00230 - R00336,R00429 RC00002,RC00078 ko00000,ko00001,ko01000,ko03009 - - - ACT_4,HD_4,RelA_SpoT,TGS k59_252316_1 1484460.JSWG01000009_gene680 1.81e-111 333.0 COG0168@1|root,COG0168@2|Bacteria,4NGMF@976|Bacteroidetes,1HXPV@117743|Flavobacteriia 976|Bacteroidetes P Trk-type K transport systems, membrane components trkH - - ko:K03498 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - - TrkH k59_1553261_1 944435.AXAJ01000002_gene4605 5.08e-14 68.9 COG1522@1|root,COG1522@2|Bacteria,1MX7R@1224|Proteobacteria,2VQ1S@28216|Betaproteobacteria,1K30H@119060|Burkholderiaceae 28216|Betaproteobacteria K PFAM regulatory protein AsnC Lrp family - GO:0001101,GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008150,GO:0009889,GO:0010033,GO:0010243,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0042221,GO:0043200,GO:0043565,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1901698,GO:1901700,GO:1903506,GO:2000112,GO:2001141 - ko:K03719 - - - - ko00000,ko03000,ko03036 - - - AsnC_trans_reg,HTH_24 k59_1553261_2 519989.ECTPHS_05586 8.08e-22 94.0 COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,1RNXA@1236|Gammaproteobacteria,1WWTQ@135613|Chromatiales 135613|Chromatiales E PFAM aminotransferase, class I - - - - - - - - - - - - Aminotran_1_2 k59_1213256_1 224914.BMEI0081 9.77e-20 89.0 COG0500@1|root,COG2226@2|Bacteria,1NA7K@1224|Proteobacteria,2TT7T@28211|Alphaproteobacteria,1J263@118882|Brucellaceae 28211|Alphaproteobacteria H Methyltransferase domain MA20_39625 - - - - - - - - - - - Methyltransf_11 k59_1213256_2 1122137.AQXF01000001_gene2878 8.54e-37 135.0 COG3243@1|root,COG3243@2|Bacteria,1Q6YK@1224|Proteobacteria,2TTVK@28211|Alphaproteobacteria 28211|Alphaproteobacteria I COG3243 Poly(3-hydroxyalkanoate) synthetase phbC - - ko:K03821 ko00650,map00650 - R04254 RC00004 ko00000,ko00001,ko01000 - - - Abhydrolase_1,Abhydrolase_6 k59_367020_1 436308.Nmar_1198 1.66e-11 64.3 COG0585@1|root,arCOG04252@2157|Archaea,41S7C@651137|Thaumarchaeota 651137|Thaumarchaeota J tRNA pseudouridine synthase - - 5.4.99.27 ko:K06176 - - - - ko00000,ko01000,ko03016 - - - TruD k59_367020_2 1229909.NSED_06830 1.83e-122 368.0 COG4257@1|root,arCOG03564@2157|Archaea,41SM7@651137|Thaumarchaeota 651137|Thaumarchaeota V antibiotic catabolic process - - - ko:K18235 - - - - ko00000,ko01000,ko01504 - - - - k59_591620_1 1123269.NX02_18980 9.74e-17 75.5 COG0662@1|root,COG0662@2|Bacteria,1R2CZ@1224|Proteobacteria,2TZHV@28211|Alphaproteobacteria,2K87N@204457|Sphingomonadales 204457|Sphingomonadales G Cupin 2, conserved barrel domain protein - - - - - - - - - - - - - k59_591620_2 1123269.NX02_18970 2.2e-47 160.0 COG3384@1|root,COG3384@2|Bacteria,1MW77@1224|Proteobacteria,2TRP1@28211|Alphaproteobacteria,2K5XQ@204457|Sphingomonadales 204457|Sphingomonadales S Catalytic LigB subunit of aromatic ring-opening dioxygenase - - 1.13.11.16 ko:K05713,ko:K15755 ko00360,ko00621,ko01100,ko01120,ko01220,map00360,map00621,map01100,map01120,map01220 M00544,M00545 R04376,R05415,R06788 RC01140,RC01306,RC01364 br01602,ko00000,ko00001,ko00002,ko01000 - - - LigB k59_367024_1 267608.RSp1080 6.24e-16 88.2 COG4655@1|root,COG4655@2|Bacteria,1R41B@1224|Proteobacteria,2VK02@28216|Betaproteobacteria,1K1HT@119060|Burkholderiaceae 28216|Betaproteobacteria S Putative Tad-like Flp pilus-assembly - - - - - - - - - - - - Tad,Tad_C k59_646269_1 1384484.AEQU_1696 8.88e-17 78.6 COG3695@1|root,COG3695@2|Bacteria,2I69R@201174|Actinobacteria,4CW36@84998|Coriobacteriia 84998|Coriobacteriia L 6-O-methylguanine DNA methyltransferase, DNA binding domain - - - ko:K07443 - - - - ko00000 - - - DNA_binding_1 k59_646269_2 497964.CfE428DRAFT_4347 4.05e-07 49.7 COG2514@1|root,COG2514@2|Bacteria,46SQP@74201|Verrucomicrobia 74201|Verrucomicrobia S PFAM Glyoxalase bleomycin resistance protein dioxygenase - - 1.13.11.2 ko:K07104 ko00361,ko00362,ko00622,ko00643,ko01100,ko01120,ko01220,map00361,map00362,map00622,map00643,map01100,map01120,map01220 M00569 R00816,R04089,R05295,R05404,R05406,R07795 RC00387,RC00643,RC01075,RC01364,RC01914 ko00000,ko00001,ko00002,ko01000 - - - Glyoxalase k59_1155625_1 1046714.AMRX01000003_gene412 3.55e-20 93.2 COG2089@1|root,COG2089@2|Bacteria,1MWG3@1224|Proteobacteria,1RPIG@1236|Gammaproteobacteria,464CM@72275|Alteromonadaceae 1236|Gammaproteobacteria M COG2089 Sialic acid synthase neuB - 2.5.1.56 ko:K01654 ko00520,ko01100,map00520,map01100 - R01804,R04435 RC00159 ko00000,ko00001,ko01000 - - - NeuB,SAF k59_1496788_1 1123274.KB899413_gene889 0.000478 39.3 2B9ZZ@1|root,323DM@2|Bacteria 2|Bacteria S COG NOG15344 non supervised orthologous group - - - - - - - - - - - - - k59_1383383_2 296591.Bpro_2222 0.000485 45.8 COG0589@1|root,COG0589@2|Bacteria,1N8EJ@1224|Proteobacteria,2VW27@28216|Betaproteobacteria,4AJNR@80864|Comamonadaceae 28216|Betaproteobacteria T Universal stress protein family - - - - - - - - - - - - Usp k59_1383383_3 1229909.NSED_03465 3.58e-54 179.0 COG0517@1|root,arCOG00600@2157|Archaea 2157|Archaea K CBS domain - - - ko:K07182 - - - - ko00000 - - - CBS k59_928734_2 391625.PPSIR1_28278 2.37e-42 150.0 COG3752@1|root,COG3752@2|Bacteria,1MXCP@1224|Proteobacteria,42R9G@68525|delta/epsilon subdivisions,2WMTN@28221|Deltaproteobacteria 28221|Deltaproteobacteria S 3-oxo-5-alpha-steroid 4-dehydrogenase - - - - - - - - - - - - DUF1295 k59_1213283_1 316407.4902956 4.74e-101 293.0 29IKC@1|root,305HJ@2|Bacteria,1QJ60@1224|Proteobacteria,1RPEI@1236|Gammaproteobacteria,3XNE1@561|Escherichia 1236|Gammaproteobacteria O Inhibitor of vertebrate lysozyme ivy GO:0003674,GO:0004857,GO:0005575,GO:0005623,GO:0006457,GO:0008150,GO:0009987,GO:0030234,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043086,GO:0044092,GO:0044464,GO:0050790,GO:0060241,GO:0061077,GO:0065007,GO:0065009,GO:0098772 - - - - - - - - - - Ivy k59_984430_1 1144305.PMI02_02168 7.29e-31 123.0 COG0457@1|root,COG0457@2|Bacteria,1Q7UR@1224|Proteobacteria,2U8BX@28211|Alphaproteobacteria,2K0N1@204457|Sphingomonadales 204457|Sphingomonadales S Tetratricopeptide repeat - - - - - - - - - - - - - k59_1098645_1 765913.ThidrDRAFT_1427 8.06e-35 128.0 COG1281@1|root,COG1281@2|Bacteria,1MUMU@1224|Proteobacteria,1RMP3@1236|Gammaproteobacteria,1WWKK@135613|Chromatiales 135613|Chromatiales O Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress hslO - - ko:K04083 - - - - ko00000,ko03110 - - - HSP33 k59_1664264_1 869210.Marky_0001 8.77e-14 75.1 COG0593@1|root,COG0593@2|Bacteria,1WIHX@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus L it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids dnaA GO:0003674,GO:0003676,GO:0003677,GO:0003688,GO:0003690,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0034641,GO:0034645,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901576,GO:1990837 - ko:K02313 ko02020,ko04112,map02020,map04112 - - - ko00000,ko00001,ko03032,ko03036 - - - Bac_DnaA,Bac_DnaA_C,DnaA_N k59_1045097_1 436308.Nmar_0072 2.9e-24 99.4 COG3276@1|root,arCOG01563@2157|Archaea,41S80@651137|Thaumarchaeota 651137|Thaumarchaeota J Initiation factor - - - ko:K03242 ko03013,map03013 - - - ko00000,ko00001,ko03012 - - - GTP_EFTU,eIF2_C k59_367055_1 1033802.SSPSH_002018 0.000165 46.6 COG0146@1|root,COG0146@2|Bacteria,1QU46@1224|Proteobacteria,1T2DW@1236|Gammaproteobacteria 1236|Gammaproteobacteria EQ COG0146 N-methylhydantoinase B acetone carboxylase, alpha subunit hyuB - 3.5.2.14 ko:K01474 ko00330,ko01100,map00330,map01100 - R03187 RC00632 ko00000,ko00001,ko01000 - - - Hydantoinase_B k59_367055_2 983920.Y88_0559 1.65e-63 197.0 COG0386@1|root,COG0386@2|Bacteria,1RD1R@1224|Proteobacteria,2U7R3@28211|Alphaproteobacteria,2K47B@204457|Sphingomonadales 204457|Sphingomonadales O Belongs to the glutathione peroxidase family gpo - 1.11.1.9 ko:K00432 ko00480,ko00590,ko04918,map00480,map00590,map04918 - R00274,R07034,R07035 RC00011,RC00982 ko00000,ko00001,ko01000 - - - GSHPx k59_1155651_1 192952.MM_1491 5.74e-31 123.0 COG0433@1|root,arCOG00284@2157|Archaea,2Y7NC@28890|Euryarchaeota,2NBKJ@224756|Methanomicrobia 224756|Methanomicrobia L AAA-like domain - - - ko:K06915 - - - - ko00000 - - - DUF87 k59_1213300_1 1232683.ADIMK_0782 2.04e-19 87.8 COG0337@1|root,COG0337@2|Bacteria,1MUBK@1224|Proteobacteria,1RN4I@1236|Gammaproteobacteria,46412@72275|Alteromonadaceae 1236|Gammaproteobacteria E Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) aroB GO:0000166,GO:0003674,GO:0003824,GO:0003856,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016838,GO:0019438,GO:0019752,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046417,GO:0046872,GO:0046914,GO:0048037,GO:0050662,GO:0051287,GO:0070403,GO:0071704,GO:0097159,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 4.2.3.4 ko:K01735 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R03083 RC00847 ko00000,ko00001,ko00002,ko01000 - - iAF1260.b3389,iBWG_1329.BWG_3080,iECDH10B_1368.ECDH10B_3564,iECDH1ME8569_1439.ECDH1ME8569_3268,iECNA114_1301.ECNA114_3486,iEcDH1_1363.EcDH1_0324,iJO1366.b3389,iJR904.b3389,iY75_1357.Y75_RS20275 DHQ_synthase k59_1213300_2 1056820.KB900639_gene366 6.07e-22 94.0 COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,1MU7B@1224|Proteobacteria,1RN2W@1236|Gammaproteobacteria,2PMMY@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria E GXGXG motif gltB GO:0003674,GO:0003824,GO:0004355,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006541,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0015930,GO:0016053,GO:0016491,GO:0016638,GO:0016639,GO:0019676,GO:0019740,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045181,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.4.1.13,1.4.1.14 ko:K00265 ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 - R00093,R00114,R00248 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - iBWG_1329.BWG_2914,iECDH10B_1368.ECDH10B_3387,iECDH1ME8569_1439.EcDH1_0495,iEcDH1_1363.EcDH1_0495,iPC815.YPO3557 GATase_2,GXGXG,Glu_syn_central,Glu_synthase k59_310167_2 95619.PM1_0201775 1.52e-44 154.0 COG3803@1|root,COG3803@2|Bacteria,1RHYI@1224|Proteobacteria,1S40A@1236|Gammaproteobacteria 1236|Gammaproteobacteria S protein conserved in bacteria - - - - - - - - - - - - DUF924 k59_1609230_1 570952.ATVH01000014_gene2068 2.56e-20 90.9 COG0697@1|root,COG0697@2|Bacteria 2|Bacteria EG spore germination - - - - - - - - - - - - EamA k59_875366_1 96561.Dole_1053 1.38e-56 183.0 COG2128@1|root,COG2128@2|Bacteria,1PSNE@1224|Proteobacteria,42XCT@68525|delta/epsilon subdivisions,2WSJD@28221|Deltaproteobacteria,2MP2A@213118|Desulfobacterales 28221|Deltaproteobacteria S Carboxymuconolactone decarboxylase family - - - - - - - - - - - - CMD k59_875366_2 935866.JAER01000015_gene1695 9.99e-11 60.1 COG0231@1|root,COG0231@2|Bacteria,2GJMS@201174|Actinobacteria,4DPJT@85009|Propionibacteriales 201174|Actinobacteria J Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase efp GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - ko:K02356 - - - - ko00000,ko03012 - - - EFP,EFP_N,Elong-fact-P_C k59_875368_2 1279009.ADICEAN_02615 2.04e-15 77.0 COG2234@1|root,COG2234@2|Bacteria,4NG2A@976|Bacteroidetes,47KMC@768503|Cytophagia 976|Bacteroidetes S PFAM Peptidase family M28 ywaD - - - - - - - - - - - Peptidase_M28 k59_194944_3 626887.J057_23685 2.42e-08 56.2 COG3170@1|root,COG3170@2|Bacteria,1QV1N@1224|Proteobacteria,1T261@1236|Gammaproteobacteria,465VJ@72275|Alteromonadaceae 1236|Gammaproteobacteria NU Protein of unknown function (DUF1631) - - - - - - - - - - - - DUF1631 k59_421122_1 290512.Paes_0859 9.89e-59 188.0 COG0302@1|root,COG0302@2|Bacteria,1FD81@1090|Chlorobi 1090|Chlorobi F PFAM GTP cyclohydrolase I folE - 3.5.4.16 ko:K01495 ko00790,ko01100,map00790,map01100 M00126,M00841,M00842,M00843 R00428,R04639,R05046,R05048 RC00263,RC00294,RC00323,RC00945,RC01188 ko00000,ko00001,ko00002,ko01000 - - - GTP_cyclohydroI k59_421122_2 1379270.AUXF01000004_gene3098 1.48e-10 60.1 COG0720@1|root,COG0720@2|Bacteria,1ZTV2@142182|Gemmatimonadetes 142182|Gemmatimonadetes H 6-pyruvoyl tetrahydropterin synthase - - 4.1.2.50,4.2.3.12 ko:K01737 ko00790,ko01100,map00790,map01100 M00842,M00843 R04286,R09959 RC01117,RC02846,RC02847 ko00000,ko00001,ko00002,ko01000,ko03016 - - - PTPS k59_1723009_2 864702.OsccyDRAFT_2137 6.45e-40 154.0 COG0823@1|root,COG1404@1|root,COG1520@1|root,COG2931@1|root,COG4655@1|root,COG0823@2|Bacteria,COG1404@2|Bacteria,COG1520@2|Bacteria,COG2931@2|Bacteria,COG4655@2|Bacteria,1G0DX@1117|Cyanobacteria,1H8AY@1150|Oscillatoriales 1117|Cyanobacteria Q COG2931 RTX toxins and related Ca2 -binding - - - - - - - - - - - - Cadherin_3,DUF11,DUF4347,HemolysinCabind,Laminin_G_3,VCBS k59_929479_1 1122137.AQXF01000006_gene968 2.64e-84 249.0 COG0197@1|root,COG0197@2|Bacteria,1RA0Z@1224|Proteobacteria,2U710@28211|Alphaproteobacteria 28211|Alphaproteobacteria J Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs rplP GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0097159,GO:1901363,GO:1990904 - ko:K02878 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L16 k59_929479_2 398580.Dshi_0293 1.84e-17 75.5 COG0255@1|root,COG0255@2|Bacteria,1N6PR@1224|Proteobacteria,2UF59@28211|Alphaproteobacteria 28211|Alphaproteobacteria J Belongs to the universal ribosomal protein uL29 family rpmC GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - ko:K02904 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L29 k59_929479_3 1120705.FG95_02568 2.56e-21 85.5 COG0186@1|root,COG0186@2|Bacteria,1MZIK@1224|Proteobacteria,2UBRF@28211|Alphaproteobacteria,2K5VH@204457|Sphingomonadales 204457|Sphingomonadales J One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA rpsQ - - ko:K02961 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S17 k59_647049_2 391615.ABSJ01000037_gene864 2.57e-65 208.0 COG2370@1|root,COG2370@2|Bacteria,1MV6Z@1224|Proteobacteria,1RNIU@1236|Gammaproteobacteria,1JA9J@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O HupE / UreJ protein - - - - - - - - - - - - HupE_UreJ_2 k59_368119_1 177437.HRM2_33300 2.53e-62 204.0 COG1638@1|root,COG1638@2|Bacteria,1PJFW@1224|Proteobacteria,42PXK@68525|delta/epsilon subdivisions,2WJFU@28221|Deltaproteobacteria,2MJCH@213118|Desulfobacterales 28221|Deltaproteobacteria G PFAM Bacterial extracellular solute-binding protein, family 7 - - - - - - - - - - - - DctP k59_253401_1 1042377.AFPJ01000025_gene626 1.1e-30 112.0 COG0567@1|root,COG0567@2|Bacteria,1MVBF@1224|Proteobacteria,1RN8K@1236|Gammaproteobacteria,465AY@72275|Alteromonadaceae 1236|Gammaproteobacteria C COG0567 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes sucA GO:0003674,GO:0003824,GO:0004591,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016491,GO:0016624,GO:0016903,GO:0016999,GO:0017144,GO:0019752,GO:0032991,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045239,GO:0045240,GO:0045252,GO:0045333,GO:0055114,GO:0071704,GO:0072350,GO:1902494,GO:1990204,GO:1990234 1.2.4.2 ko:K00164 ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00032 R00621,R01933,R01940,R03316,R08549 RC00004,RC00027,RC00627,RC02743,RC02833,RC02883 br01601,ko00000,ko00001,ko00002,ko01000 - - - 2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr k59_253407_1 580332.Slit_1690 6.5e-55 177.0 COG0425@1|root,COG0425@2|Bacteria,1PX23@1224|Proteobacteria,2WCJT@28216|Betaproteobacteria,44W8S@713636|Nitrosomonadales 28216|Betaproteobacteria O Sulfurtransferase TusA - - - - - - - - - - - - TusA k59_85710_2 1382306.JNIM01000001_gene1895 1.06e-62 204.0 COG1478@1|root,COG1478@2|Bacteria,2G5TU@200795|Chloroflexi 200795|Chloroflexi S TIGRFAM F420-dependent oxidoreductase - - 6.3.2.31,6.3.2.34 ko:K12234 ko00680,ko01120,map00680,map01120 M00378 R09399,R09400 RC00064,RC00090,RC00141 ko00000,ko00001,ko00002,ko01000 - - - F420_ligase k59_85710_3 500633.CLOHIR_00759 3.89e-39 140.0 COG0218@1|root,COG0218@2|Bacteria,1TSPW@1239|Firmicutes,24836@186801|Clostridia,25QD6@186804|Peptostreptococcaceae 186801|Clostridia D Necessary for normal cell division and for the maintenance of normal septation engB - - ko:K03978 - - - - ko00000,ko03036 - - - MMR_HSR1 k59_706019_1 1122137.AQXF01000001_gene3255 2.11e-120 362.0 COG0443@1|root,COG0443@2|Bacteria,1MVEN@1224|Proteobacteria,2TR5H@28211|Alphaproteobacteria 28211|Alphaproteobacteria O Heat shock 70 kDa protein dnaK - - ko:K04043 ko03018,ko04212,ko05152,map03018,map04212,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 1.A.33.1 - - HSP70 k59_421887_1 1415778.JQMM01000001_gene1767 5.49e-77 234.0 COG0560@1|root,COG0560@2|Bacteria,1MZPG@1224|Proteobacteria,1RRRU@1236|Gammaproteobacteria,1J5MZ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E COG0560 Phosphoserine phosphatase thrH - 2.7.1.39,3.1.3.3 ko:K02203 ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00680,map01100,map01110,map01120,map01130,map01230 M00018 R00582,R01771 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - HAD,Hydrolase k59_140992_1 1131266.ARWQ01000010_gene30 2.18e-88 268.0 COG1180@1|root,arCOG00946@2157|Archaea,41SBZ@651137|Thaumarchaeota 651137|Thaumarchaeota C Radical SAM - - 1.97.1.4 ko:K04069 - - R04710 - ko00000,ko01000 - - - Radical_SAM k59_85727_1 436308.Nmar_0871 3.68e-238 661.0 COG0017@1|root,arCOG00406@2157|Archaea,41SBT@651137|Thaumarchaeota 651137|Thaumarchaeota J Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) - - 6.1.1.23 ko:K09759 ko00970,map00970 M00360 R03647,R05577 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_2,tRNA_anti-codon k59_985241_1 658612.MD26_02120 5.07e-23 95.1 COG3571@1|root,COG3571@2|Bacteria,1RD20@1224|Proteobacteria,1S3Y4@1236|Gammaproteobacteria 1236|Gammaproteobacteria S hydrolase of the alpha beta-hydrolase fold - - - ko:K07020 - - - - ko00000 - - - Abhydrolase_6,DLH k59_985241_2 498211.CJA_2382 5.07e-19 80.9 COG3089@1|root,COG3089@2|Bacteria,1N6TM@1224|Proteobacteria,1SCDE@1236|Gammaproteobacteria,1FHR3@10|Cellvibrio 1236|Gammaproteobacteria S Uncharacterised protein family (UPF0270) yheU - - ko:K09898 - - - - ko00000 - - - UPF0270 k59_1665108_2 926559.JoomaDRAFT_3847 4.86e-33 126.0 COG3119@1|root,COG3119@2|Bacteria,4NEBN@976|Bacteroidetes,1HZSK@117743|Flavobacteriia 976|Bacteroidetes P sulfatase - - 3.1.6.1 ko:K01130 ko00140,ko00600,map00140,map00600 - R03980,R04856 RC00128,RC00231 ko00000,ko00001,ko01000 - - - Sulfatase k59_85731_1 1218108.KB908291_gene805 8.8e-13 68.9 COG2270@1|root,COG2270@2|Bacteria,4PM3J@976|Bacteroidetes,1IKI6@117743|Flavobacteriia 976|Bacteroidetes S Transmembrane secretion effector - - - ko:K08217 - - - - br01600,ko00000,ko01504,ko02000 2.A.1.21.1,2.A.1.21.22 - - MFS_1,MFS_3 k59_85731_2 1094980.Mpsy_3062 4.89e-33 122.0 COG1266@1|root,arCOG02768@2157|Archaea,2XZ3X@28890|Euryarchaeota,2NAUF@224756|Methanomicrobia 224756|Methanomicrobia S CAAX protease self-immunity - - - ko:K07052 - - - - ko00000 - - - Abi k59_1497938_1 580332.Slit_1716 5.14e-58 181.0 2BK43@1|root,32EHP@2|Bacteria,1RDAC@1224|Proteobacteria,2W3NZ@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_1497938_2 580332.Slit_1717 1.45e-36 127.0 COG1047@1|root,COG1047@2|Bacteria,1REQ1@1224|Proteobacteria,2W324@28216|Betaproteobacteria 28216|Betaproteobacteria O Peptidyl-prolyl cis-trans - - 5.2.1.8 ko:K03775 - - - - ko00000,ko01000,ko03110 - - - - k59_1560891_2 1380394.JADL01000001_gene2267 1.37e-39 136.0 COG1983@1|root,COG1983@2|Bacteria,1NECC@1224|Proteobacteria,2UEYZ@28211|Alphaproteobacteria,2JTP5@204441|Rhodospirillales 204441|Rhodospirillales KT PspC domain - - - ko:K03973 - - - - ko00000,ko02048,ko03000 - - - PspC k59_201637_2 1089453.GOSPT_114_00260 1.26e-14 77.8 COG2902@1|root,COG2902@2|Bacteria,2GK0C@201174|Actinobacteria,4GA3Z@85026|Gordoniaceae 201174|Actinobacteria E Bacterial NAD-glutamate dehydrogenase gdh GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944 1.4.1.2 ko:K15371 ko00220,ko00250,ko00430,ko00910,ko01100,map00220,map00250,map00430,map00910,map01100 - R00243 RC00006,RC02799 ko00000,ko00001,ko01000 - - - Bac_GDH k59_598821_1 269799.Gmet_3337 5.36e-36 140.0 COG1198@1|root,COG1198@2|Bacteria,1MUUZ@1224|Proteobacteria,42MNH@68525|delta/epsilon subdivisions,2WJ4G@28221|Deltaproteobacteria,43U9D@69541|Desulfuromonadales 28221|Deltaproteobacteria L Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA priA - - ko:K04066 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,Helicase_C,ResIII k59_1669514_1 330214.NIDE3734 1.92e-67 210.0 COG0356@1|root,COG0356@2|Bacteria,3J0RW@40117|Nitrospirae 40117|Nitrospirae C it plays a direct role in the translocation of protons across the membrane atpB - - ko:K02108 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko03110 3.A.2.1 - - ATP-synt_A k59_1669514_2 330214.NIDE3733 1.64e-13 65.1 COG0636@1|root,COG0636@2|Bacteria,3J198@40117|Nitrospirae 40117|Nitrospirae C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation atpE - - ko:K02110 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt_C k59_34422_1 313628.LNTAR_25210 2.6e-11 66.6 COG3119@1|root,COG3119@2|Bacteria 2|Bacteria P arylsulfatase activity - - - - - - - - - - - - Sulfatase k59_1390656_1 1229909.NSED_00105 1.06e-81 253.0 COG2073@1|root,arCOG00651@2157|Archaea,41S83@651137|Thaumarchaeota 651137|Thaumarchaeota H Cobalamin synthesis G C-terminus - - 3.7.1.12 ko:K02189 ko00860,ko01100,map00860,map01100 - R07772 RC01545,RC02097 ko00000,ko00001,ko01000 - - - CbiG_C,CbiG_N,CbiG_mid k59_1442299_1 1268240.ATFI01000008_gene2070 1.47e-35 145.0 arCOG08054@1|root,2Z8AD@2|Bacteria,4NJ65@976|Bacteroidetes,2FP4Z@200643|Bacteroidia,4ANWG@815|Bacteroidaceae 976|Bacteroidetes S Carbohydrate-binding domain-containing protein Cthe_2159 - - - - - - - - - - - - Cthe_2159 k59_1162335_1 1415778.JQMM01000001_gene795 7.39e-38 137.0 COG0112@1|root,COG0112@2|Bacteria,1MUIS@1224|Proteobacteria,1RMHQ@1236|Gammaproteobacteria,1J4EX@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism glyA GO:0001505,GO:0003674,GO:0003824,GO:0004372,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006544,GO:0006545,GO:0006546,GO:0006563,GO:0006565,GO:0006730,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008270,GO:0008652,GO:0009056,GO:0009058,GO:0009063,GO:0009069,GO:0009070,GO:0009071,GO:0009987,GO:0016053,GO:0016054,GO:0016740,GO:0016741,GO:0016742,GO:0017144,GO:0019264,GO:0019752,GO:0019842,GO:0030170,GO:0036094,GO:0042133,GO:0042135,GO:0042136,GO:0042737,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046395,GO:0046872,GO:0046914,GO:0048037,GO:0050662,GO:0065007,GO:0065008,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1901607 2.1.2.1 ko:K00600 ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523 M00140,M00141,M00346,M00532 R00945,R09099 RC00022,RC00112,RC01583,RC02958 ko00000,ko00001,ko00002,ko01000 - - iG2583_1286.G2583_3081 SHMT k59_374053_1 1499967.BAYZ01000152_gene1383 1.83e-19 96.7 COG3437@1|root,COG5002@1|root,COG3437@2|Bacteria,COG5002@2|Bacteria 2|Bacteria T protein histidine kinase activity - - 2.7.13.3 ko:K07814,ko:K11527 - - - - ko00000,ko01000,ko01001,ko02022 - - - GAF,GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg k59_1103856_1 980584.AFPB01000003_gene3413 9.48e-92 278.0 COG3385@1|root,COG3385@2|Bacteria,4NHKV@976|Bacteroidetes,1I1NC@117743|Flavobacteriia 976|Bacteroidetes L Pfam Transposase DDE domain - - - - - - - - - - - - DDE_Tnp_1,DUF4372 k59_711985_1 1042375.AFPL01000022_gene2519 5.95e-64 213.0 COG0062@1|root,COG0063@1|root,COG0062@2|Bacteria,COG0063@2|Bacteria,1MU1Q@1224|Proteobacteria,1RMPS@1236|Gammaproteobacteria,4654W@72275|Alteromonadaceae 1236|Gammaproteobacteria G Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration nnrD GO:0003674,GO:0003824,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016854,GO:0052855,GO:0052856,GO:0052857 4.2.1.136,5.1.99.6 ko:K17758,ko:K17759 - - - - ko00000,ko01000 - - - Carb_kinase,YjeF_N k59_882437_1 1122137.AQXF01000004_gene1650 1.26e-114 360.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,2TQR7@28211|Alphaproteobacteria 28211|Alphaproteobacteria T methyl-accepting chemotaxis protein - - - - - - - - - - - - MCPsignal k59_1051256_1 1231190.NA8A_23834 3.1e-48 158.0 COG3476@1|root,COG3476@2|Bacteria,1MZC1@1224|Proteobacteria,2UBYB@28211|Alphaproteobacteria,43Q7M@69277|Phyllobacteriaceae 28211|Alphaproteobacteria T TspO/MBR family tspO - - ko:K05770 ko04080,ko04214,ko04979,ko05166,map04080,map04214,map04979,map05166 - - - ko00000,ko00001,ko02000 9.A.24 - - TspO_MBR k59_90623_2 518766.Rmar_0225 4.2e-13 71.2 COG2010@1|root,COG2010@2|Bacteria,4PHUX@976|Bacteroidetes,1FJC8@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes C Cytochrome C oxidase, cbb3-type, subunit III - - - - - - - - - - - - Cytochrome_CBB3 k59_34453_1 1229909.NSED_08875 4.28e-100 311.0 COG0640@1|root,COG1328@1|root,arCOG01680@2157|Archaea,arCOG04889@2157|Archaea,41SBG@651137|Thaumarchaeota 651137|Thaumarchaeota FK Anaerobic ribonucleoside-triphosphate reductase - - 1.1.98.6 ko:K21636 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R11633,R11634,R11635,R11636 RC00613 ko00000,ko00001,ko00002,ko01000 - - - ATP-cone,HTH_20,NRDD k59_1614784_1 1229909.NSED_02115 6.09e-95 287.0 COG1503@1|root,arCOG01742@2157|Archaea 1229909.NSED_02115|- J Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA - - - ko:K03265 ko03015,map03015 - - - ko00000,ko00001,ko03012,ko03019 - - - - k59_764004_1 765913.ThidrDRAFT_1771 2.66e-117 352.0 COG2308@1|root,COG2308@2|Bacteria,1MUAD@1224|Proteobacteria,1RNAF@1236|Gammaproteobacteria,1WW4F@135613|Chromatiales 135613|Chromatiales S Circularly permuted ATP-grasp type 2 - - - - - - - - - - - - CP_ATPgrasp_2 k59_1779777_1 754476.Q7A_1014 3.19e-50 174.0 COG0771@1|root,COG0771@2|Bacteria,1MVYD@1224|Proteobacteria,1RP25@1236|Gammaproteobacteria,45ZS1@72273|Thiotrichales 72273|Thiotrichales M Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) murD - 6.3.2.9 ko:K01925 ko00471,ko00550,ko01100,map00471,map00550,map01100 - R02783 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase_C,Mur_ligase_M k59_1103872_1 641491.DND132_2668 8.55e-41 146.0 COG1296@1|root,COG1296@2|Bacteria,1P6U3@1224|Proteobacteria,42QVQ@68525|delta/epsilon subdivisions,2WMW1@28221|Deltaproteobacteria,2MCDV@213115|Desulfovibrionales 28221|Deltaproteobacteria E AzlC protein - - - - - - - - - - - - AzlC k59_259382_1 1007105.PT7_2177 1.77e-16 73.2 COG2104@1|root,COG2104@2|Bacteria,1NG8E@1224|Proteobacteria,2VVVB@28216|Betaproteobacteria,3T4V6@506|Alcaligenaceae 28216|Betaproteobacteria H Sulfur transfer protein involved in thiamine biosynthesis thiS - - ko:K03154 ko04122,map04122 - - - ko00000,ko00001 - - - ThiS k59_259382_2 1123320.KB889700_gene9193 1.2e-26 108.0 COG4175@1|root,COG4175@2|Bacteria,2GJC0@201174|Actinobacteria 201174|Actinobacteria E glycine betaine proV - 3.6.3.32 ko:K02000 ko02010,map02010 M00208 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.12 - - ABC_tran,CBS k59_1329469_3 1232683.ADIMK_3569 3.74e-08 55.8 COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,1RN2C@1236|Gammaproteobacteria,4656T@72275|Alteromonadaceae 1236|Gammaproteobacteria P COG2217 Cation transport ATPase actP - 3.6.3.54 ko:K17686,ko:K19597 ko01524,ko04016,map01524,map04016 - R00086 RC00002 ko00000,ko00001,ko01000 3.A.3.5,3.A.3.5.20 - - E1-E2_ATPase,HMA,Hydrolase k59_822072_1 1111728.ATYS01000019_gene3413 7.64e-17 82.4 COG0330@1|root,COG0330@2|Bacteria,1MUM2@1224|Proteobacteria,1RMUG@1236|Gammaproteobacteria 1236|Gammaproteobacteria O HflC and HflK could encode or regulate a protease hflK GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006508,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008233,GO:0009266,GO:0009408,GO:0009628,GO:0009897,GO:0009986,GO:0016020,GO:0016021,GO:0016787,GO:0019538,GO:0031224,GO:0031226,GO:0031233,GO:0032991,GO:0043086,GO:0043170,GO:0044092,GO:0044238,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0050790,GO:0050896,GO:0065007,GO:0065009,GO:0071575,GO:0071704,GO:0071944,GO:0098552,GO:0098796,GO:0140096,GO:1901564 - ko:K04088 - M00742 - - ko00000,ko00002,ko01000 - - - Band_7,HflK_N k59_822072_2 243233.MCA1980 2.19e-20 89.4 COG0330@1|root,COG0330@2|Bacteria,1MV7R@1224|Proteobacteria,1RM8Z@1236|Gammaproteobacteria,1XDPP@135618|Methylococcales 135618|Methylococcales O HflC and HflK could regulate a protease - - - ko:K04087 - M00742 - - ko00000,ko00002,ko01000 - - - Band_7 k59_317505_1 722419.PH505_cu00040 2.49e-21 88.6 COG4445@1|root,COG4445@2|Bacteria,1QMPR@1224|Proteobacteria,1RYZP@1236|Gammaproteobacteria,2PZYS@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria FJ COG4445 Hydroxylase for synthesis of 2-methylthio-cis-ribozeatin in tRNA - - - ko:K06169 - - - - ko00000,ko01000,ko03016 - - - MiaE k59_317505_2 744979.R2A130_0826 3.51e-52 177.0 COG3264@1|root,COG3264@2|Bacteria,1MWSA@1224|Proteobacteria,2TRKK@28211|Alphaproteobacteria 28211|Alphaproteobacteria M mechanosensitive ion channel MA20_40450 - - - - - - - - - - - MS_channel k59_1162381_2 717785.HYPMC_0591 4.08e-10 63.2 COG0573@1|root,COG0573@2|Bacteria,1MVKP@1224|Proteobacteria,2TQU1@28211|Alphaproteobacteria,3N6BZ@45401|Hyphomicrobiaceae 28211|Alphaproteobacteria P probably responsible for the translocation of the substrate across the membrane pstC - - ko:K02037 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - BPD_transp_1 k59_259402_1 1380394.JADL01000004_gene5869 9.14e-52 178.0 COG5276@1|root,COG5276@2|Bacteria,1MU72@1224|Proteobacteria,2TZVG@28211|Alphaproteobacteria,2JUDH@204441|Rhodospirillales 204441|Rhodospirillales L Secreted protein containing C-terminal beta-propeller domain distantly related to WD-40 repeats - - - - - - - - - - - - LVIVD k59_1505018_1 1279017.AQYJ01000024_gene866 1.08e-94 298.0 COG1185@1|root,COG1185@2|Bacteria,1MVB9@1224|Proteobacteria,1RNBF@1236|Gammaproteobacteria,4651T@72275|Alteromonadaceae 1236|Gammaproteobacteria J Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction pnp GO:0000166,GO:0000175,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004518,GO:0004527,GO:0004532,GO:0004540,GO:0004654,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0008408,GO:0009056,GO:0009057,GO:0009266,GO:0009408,GO:0009628,GO:0009892,GO:0009987,GO:0010468,GO:0010605,GO:0010629,GO:0016070,GO:0016071,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016796,GO:0016896,GO:0017076,GO:0019001,GO:0019222,GO:0019439,GO:0030551,GO:0032553,GO:0032555,GO:0032561,GO:0034641,GO:0034655,GO:0035438,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0050896,GO:0060255,GO:0065007,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0097159,GO:0097367,GO:0140098,GO:1901265,GO:1901360,GO:1901361,GO:1901363,GO:1901575 2.7.7.8 ko:K00962 ko00230,ko00240,ko03018,map00230,map00240,map03018 M00394 R00437,R00438,R00439,R00440 RC02795 ko00000,ko00001,ko00002,ko01000,ko03016,ko03019 - - - KH_1,PNPase,RNase_PH,RNase_PH_C,S1 k59_600214_1 1144275.COCOR_00543 1.86e-73 231.0 COG1192@1|root,COG1192@2|Bacteria,1Q4ZN@1224|Proteobacteria,43082@68525|delta/epsilon subdivisions,2WV4J@28221|Deltaproteobacteria 28221|Deltaproteobacteria D Cellulose biosynthesis protein BcsQ - - - ko:K03496 - - - - ko00000,ko03036,ko04812 - - - AAA_31 k59_652583_1 1122137.AQXF01000006_gene784 3.05e-96 286.0 COG0708@1|root,COG0708@2|Bacteria,1MVII@1224|Proteobacteria,2TR5J@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Exodeoxyribonuclease III xth - 3.1.11.2 ko:K01142 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - Exo_endo_phos k59_1220272_1 479434.Sthe_3162 1.48e-65 222.0 COG0569@1|root,COG2985@1|root,COG0569@2|Bacteria,COG2985@2|Bacteria,2G64U@200795|Chloroflexi 200795|Chloroflexi P YidE YbjL duplication domain protein - - - ko:K07085 - - - - ko00000 2.A.81 - - Asp-Al_Ex,TrkA_C k59_537688_1 1249627.D779_0366 3.63e-27 115.0 2C69V@1|root,33SX3@2|Bacteria,1NTPV@1224|Proteobacteria,1SMZB@1236|Gammaproteobacteria,1X0D2@135613|Chromatiales 135613|Chromatiales - - - - - - - - - - - - - - - k59_883786_1 666685.R2APBS1_1532 2.84e-19 92.0 COG1629@1|root,COG4771@2|Bacteria,1MWKN@1224|Proteobacteria,1RMM6@1236|Gammaproteobacteria,1X2Y6@135614|Xanthomonadales 135614|Xanthomonadales P TonB-dependent Receptor Plug Domain - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_537692_1 760192.Halhy_1749 3.18e-16 77.8 COG3000@1|root,COG3000@2|Bacteria,4NI62@976|Bacteroidetes,1IY9P@117747|Sphingobacteriia 976|Bacteroidetes I Fatty acid hydroxylase superfamily - - - - - - - - - - - - FA_hydroxylase k59_1392024_1 1133849.O3I_007980 5.31e-06 51.2 COG0300@1|root,COG0300@2|Bacteria 2|Bacteria S Belongs to the short-chain dehydrogenases reductases (SDR) family ymfI - 1.1.1.100,1.3.1.28 ko:K00059,ko:K00216,ko:K07124 ko00061,ko00333,ko00780,ko01040,ko01053,ko01100,ko01110,ko01130,ko01212,map00061,map00333,map00780,map01040,map01053,map01100,map01110,map01130,map01212 M00083,M00572 R01505,R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117,RC00534 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short,adh_short_C2 k59_1392024_3 1448389.BAVQ01000025_gene1259 1.31e-07 57.0 COG1960@1|root,COG1960@2|Bacteria,2GKVN@201174|Actinobacteria 201174|Actinobacteria I acyl-CoA dehydrogenase fadE6_1 - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_883793_1 1282360.ABAC460_15085 8.53e-19 84.0 2DMP1@1|root,32SS8@2|Bacteria,1N6W6@1224|Proteobacteria,2VGQF@28211|Alphaproteobacteria 1224|Proteobacteria S Protein of unknown function (DUF3237) - - - - - - - - - - - - DUF3237 k59_1728332_1 471852.Tcur_1859 2.05e-67 217.0 COG1804@1|root,COG1804@2|Bacteria,2GKNX@201174|Actinobacteria,4EHVM@85012|Streptosporangiales 201174|Actinobacteria C CoA-transferase family III - - 5.1.99.4 ko:K01796 ko00120,ko01100,ko04146,map00120,map01100,map04146 M00104 R08734,R08739 RC02345 ko00000,ko00001,ko00002,ko01000 - - - CoA_transf_3 k59_934978_1 1078085.HMPREF1210_00081 0.000374 46.6 COG0517@1|root,COG0517@2|Bacteria,1V0XU@1239|Firmicutes,4HD12@91061|Bacilli,26D6N@186818|Planococcaceae 91061|Bacilli S Acetoin utilization protein acuB - - ko:K04767 - - - - ko00000 - - - ACT,CBS k59_990554_1 493475.GARC_4506 4.11e-86 263.0 COG2130@1|root,COG2130@2|Bacteria,1MUC2@1224|Proteobacteria,1RNGM@1236|Gammaproteobacteria,465JP@72275|Alteromonadaceae 1236|Gammaproteobacteria S NADP-dependent - - - ko:K07119 - - - - ko00000 - - - ADH_N_2,ADH_zinc_N k59_260694_2 1096930.L284_03520 1.32e-151 434.0 COG2951@1|root,COG2951@2|Bacteria,1MUZ3@1224|Proteobacteria,2TRP0@28211|Alphaproteobacteria,2K0TV@204457|Sphingomonadales 204457|Sphingomonadales M Lytic murein transglycosylase mltB - - - - - - - - - - - SLT_2 k59_934980_1 1333856.L686_00650 2.79e-93 280.0 COG0134@1|root,COG0134@2|Bacteria,1MW5K@1224|Proteobacteria,1RNYH@1236|Gammaproteobacteria,1Z0YK@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria E Belongs to the TrpC family trpC GO:0003674,GO:0003824,GO:0004425,GO:0016829,GO:0016830,GO:0016831 4.1.1.48 ko:K01609 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R03508 RC00944 ko00000,ko00001,ko00002,ko01000 - - iJN746.PP_0422 IGPS k59_145925_1 391038.Bphy_1983 1.86e-73 236.0 COG1250@1|root,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,2VK75@28216|Betaproteobacteria,1K1T0@119060|Burkholderiaceae 28216|Betaproteobacteria I 3-hydroxyacyl-CoA dehydrogenase paaH - 1.1.1.157 ko:K00074 ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120 - R01976,R05576,R06941 RC00029,RC00117 ko00000,ko00001,ko01000 - - - 3HCDH,3HCDH_N k59_1615742_1 1122137.AQXF01000006_gene742 1.33e-150 448.0 COG4774@1|root,COG4774@2|Bacteria,1NMCN@1224|Proteobacteria,2U2UK@28211|Alphaproteobacteria 28211|Alphaproteobacteria P TonB dependent receptor - - - - - - - - - - - - Plug,TonB_dep_Rec k59_1392036_1 1353276.JADR01000007_gene1281 1.06e-80 256.0 COG3172@1|root,COG3172@2|Bacteria,4NEQF@976|Bacteroidetes,1HYEB@117743|Flavobacteriia 976|Bacteroidetes H Domain of unknown function (DUF4301) - - - - - - - - - - - - AAA_28,DUF4301 k59_1052276_1 1121033.AUCF01000033_gene3619 6.91e-22 101.0 COG0840@1|root,COG4564@1|root,COG0840@2|Bacteria,COG4564@2|Bacteria,1MU9B@1224|Proteobacteria,2TQR7@28211|Alphaproteobacteria,2JQ44@204441|Rhodospirillales 204441|Rhodospirillales T methyl-accepting chemotaxis protein - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - HAMP,MCPsignal,sCache_2 k59_764974_1 314285.KT71_02547 3.61e-41 155.0 COG0741@1|root,COG0741@2|Bacteria,1MWRW@1224|Proteobacteria,1S084@1236|Gammaproteobacteria,1J80Q@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria D Sporulation related domain - - - - - - - - - - - - SLT,SPOR k59_990566_1 1122137.AQXF01000002_gene181 3.11e-122 371.0 COG5000@1|root,COG5000@2|Bacteria,1MWKZ@1224|Proteobacteria,2TQTB@28211|Alphaproteobacteria 28211|Alphaproteobacteria T Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation ntrY GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 2.7.13.3 ko:K13598 ko02020,map02020 M00498 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,HisKA,PAS,PAS_4 k59_1392047_1 1415778.JQMM01000001_gene827 1.85e-72 226.0 COG1660@1|root,COG1660@2|Bacteria,1MVX6@1224|Proteobacteria,1RNJX@1236|Gammaproteobacteria,1J528@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Displays ATPase and GTPase activities rapZ GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005515,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0034641,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363 - ko:K06958 - - - - ko00000,ko03019 - - - ATP_bind_2 k59_537714_1 1121946.AUAX01000003_gene1597 2.86e-07 60.1 COG3209@1|root,COG3209@2|Bacteria 2|Bacteria M self proteolysis - - - - - - - - - - - - RHS_repeat,SpvB,TcdB_toxin_midN,VCBS k59_600271_1 945713.IALB_1952 4.76e-49 165.0 COG0500@1|root,COG2226@2|Bacteria 2|Bacteria Q methyltransferase arsM - 2.1.1.137 ko:K07755 - - - - ko00000,ko01000 - - - Methyltransf_11 k59_990577_1 298653.Franean1_1609 1.7e-40 144.0 COG1028@1|root,COG1028@2|Bacteria,2IBHM@201174|Actinobacteria,4EVGV@85013|Frankiales 201174|Actinobacteria IQ Enoyl-(Acyl carrier protein) reductase - - - - - - - - - - - - adh_short_C2 k59_1052294_1 472759.Nhal_1092 2.93e-85 263.0 COG0820@1|root,COG0820@2|Bacteria,1MUYK@1224|Proteobacteria,1RMUI@1236|Gammaproteobacteria,1WWD4@135613|Chromatiales 135613|Chromatiales J Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs rlmN - 2.1.1.192 ko:K06941 - - - - ko00000,ko01000,ko03009 - - - Radical_SAM k59_1392066_2 1242864.D187_006599 4.88e-34 129.0 COG4972@1|root,COG4972@2|Bacteria,1MX8P@1224|Proteobacteria,42M36@68525|delta/epsilon subdivisions,2WJFJ@28221|Deltaproteobacteria,2YUJQ@29|Myxococcales 28221|Deltaproteobacteria NU pilus assembly protein pilM - - ko:K02662 - - - - ko00000,ko02035,ko02044 - - - PilM_2 k59_883839_1 2340.JV46_22510 1.35e-41 145.0 COG0577@1|root,COG0577@2|Bacteria,1MW6D@1224|Proteobacteria,1RN49@1236|Gammaproteobacteria 1236|Gammaproteobacteria V COG0577 ABC-type antimicrobial peptide transport system permease component - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_990583_1 1096930.L284_11040 8.23e-126 379.0 COG0744@1|root,COG0744@2|Bacteria,1QTST@1224|Proteobacteria,2TQQ8@28211|Alphaproteobacteria,2K0XK@204457|Sphingomonadales 204457|Sphingomonadales M Penicillin-binding Protein - - 2.4.1.129,3.4.16.4 ko:K05366 ko00550,ko01100,ko01501,map00550,map01100,map01501 - - - ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 - Transgly,Transpeptidase k59_1505108_1 436308.Nmar_1069 1.26e-108 321.0 COG0473@1|root,arCOG01163@2157|Archaea,41SAA@651137|Thaumarchaeota 651137|Thaumarchaeota C Isocitrate isopropylmalate dehydrogenase - - 1.1.1.85 ko:K00052 ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230 M00432,M00535 R00994,R04426,R10052 RC00084,RC00417,RC03036 br01601,ko00000,ko00001,ko00002,ko01000 - - - Iso_dh k59_600301_2 1122138.AQUZ01000004_gene1004 9.01e-24 96.7 COG3740@1|root,COG3740@2|Bacteria,2IDPK@201174|Actinobacteria,4DWCW@85009|Propionibacteriales 201174|Actinobacteria S Caudovirus prohead serine protease - - - ko:K06904 - - - - ko00000 - - - Peptidase_S78 k59_145960_1 1096930.L284_05465 2.17e-74 230.0 COG1291@1|root,COG1291@2|Bacteria,1MXK3@1224|Proteobacteria,2TR5A@28211|Alphaproteobacteria,2K1GC@204457|Sphingomonadales 204457|Sphingomonadales N With MotB forms the ion channels that couple flagellar rotation to proton sodium motive force across the membrane and forms the stator elements of the rotary flagellar machine - - - ko:K02556 ko02020,ko02030,ko02040,map02020,map02030,map02040 - - - ko00000,ko00001,ko02000,ko02035 1.A.30.1 - - MotA_ExbB k59_145960_2 1096930.L284_05460 6.35e-23 92.0 2BIEC@1|root,32CKP@2|Bacteria,1Q82T@1224|Proteobacteria,2VE8J@28211|Alphaproteobacteria,2K783@204457|Sphingomonadales 204457|Sphingomonadales S STAS domain - - - - - - - - - - - - STAS_2 k59_1163718_1 436308.Nmar_1713 2.36e-61 194.0 COG1136@1|root,arCOG00922@2157|Archaea,41T2R@651137|Thaumarchaeota 651137|Thaumarchaeota E ABC-type antimicrobial peptide transport system, ATPase component - - - ko:K02003,ko:K09810 ko02010,map02010 M00255,M00258 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1,3.A.1.125 - - ABC_tran k59_260757_1 794846.AJQU01000060_gene2475 4.86e-60 203.0 COG0578@1|root,COG0578@2|Bacteria,1MUMY@1224|Proteobacteria,2TU11@28211|Alphaproteobacteria,4B6XW@82115|Rhizobiaceae 28211|Alphaproteobacteria C C-terminal domain of alpha-glycerophosphate oxidase eryB - 1.1.1.402,1.1.5.3 ko:K00111,ko:K21054 ko00564,ko01110,map00564,map01110 - R00848 RC00029 ko00000,ko00001,ko01000 - - - DAO,DAO_C k59_1562413_1 558884.JRGM01000035_gene3646 7.5e-23 100.0 COG0589@1|root,COG0589@2|Bacteria,1MVZS@1224|Proteobacteria,1RPAE@1236|Gammaproteobacteria,1Y3SH@135624|Aeromonadales 135624|Aeromonadales T Universal stress protein family - - - ko:K14055 - - - - ko00000 - - - Usp k59_1392093_2 1173264.KI913949_gene1704 1.65e-14 73.9 COG4191@1|root,COG4191@2|Bacteria,1G07W@1117|Cyanobacteria,1H7H2@1150|Oscillatoriales 1117|Cyanobacteria T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - HATPase_c,HisKA,PAS_3,PAS_4,PAS_9 k59_203085_1 436308.Nmar_1245 2.01e-71 237.0 COG0419@1|root,COG1122@1|root,arCOG00202@2157|Archaea,arCOG00368@2157|Archaea,41S9P@651137|Thaumarchaeota 651137|Thaumarchaeota LP AAA domain - - - ko:K03546 - - - - ko00000,ko03400 - - - AAA_15 k59_1786768_1 113395.AXAI01000005_gene4029 9.23e-51 190.0 COG3637@1|root,COG4206@1|root,COG3637@2|Bacteria,COG4206@2|Bacteria,1N71E@1224|Proteobacteria,2TU7B@28211|Alphaproteobacteria,3JVXG@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria H TonB dependent receptor - - - - - - - - - - - - Plug,TonB_dep_Rec k59_1111607_2 158500.BV97_00905 4.37e-43 146.0 COG0546@1|root,COG0546@2|Bacteria,1RDA7@1224|Proteobacteria,2U703@28211|Alphaproteobacteria,2K3XQ@204457|Sphingomonadales 204457|Sphingomonadales S Hydrolase - - 3.1.3.18 ko:K01091 ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130 - R01334 RC00017 ko00000,ko00001,ko01000 - - - HAD_2 k59_267557_1 314285.KT71_08279 3.69e-56 179.0 COG1764@1|root,COG1764@2|Bacteria,1RJIP@1224|Proteobacteria,1S6QM@1236|Gammaproteobacteria,1J9ZC@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O redox protein, regulator of disulfide bond formation - - - - - - - - - - - - OsmC k59_1058844_1 1268635.Loa_02507 1.27e-54 192.0 COG0045@1|root,COG1042@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,1MW98@1224|Proteobacteria,1RPXX@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Acyl-CoA synthetase (NDP forming) - - - ko:K09181 - - - - ko00000 - - - ATP-grasp_5,Acetyltransf_1,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig k59_1450261_2 1144325.PMI22_03555 1.19e-58 190.0 COG1028@1|root,COG1028@2|Bacteria,1MUBQ@1224|Proteobacteria,1RQJT@1236|Gammaproteobacteria 1236|Gammaproteobacteria IQ Belongs to the short-chain dehydrogenases reductases (SDR) family - - - - - - - - - - - - adh_short,adh_short_C2 k59_720573_1 449447.MAE_60270 1.63e-19 92.0 COG3409@1|root,COG3772@1|root,COG3409@2|Bacteria,COG3772@2|Bacteria,1G4TY@1117|Cyanobacteria 1117|Cyanobacteria G Phage lysozyme - - 3.2.1.17 ko:K01185 - - - - ko00000,ko01000 - - - PG_binding_1,Phage_lysozyme k59_1399013_1 1150474.JQJI01000017_gene587 5.2e-88 280.0 COG0021@1|root,COG0021@2|Bacteria 2|Bacteria G Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate - - 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 - - - Transket_pyr,Transketolase_N,XFP,XFP_N k59_544319_1 1333856.L686_16765 9.05e-14 72.0 COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,1RMBS@1236|Gammaproteobacteria,1Z1T7@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria NU COG2804 Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB mshE - - ko:K12276 ko05111,map05111 - - - ko00000,ko00001,ko02044 - - - T2SSE,T2SSE_N k59_544319_2 1122194.AUHU01000004_gene1519 1.92e-14 75.5 COG1459@1|root,COG1459@2|Bacteria,1MV4U@1224|Proteobacteria,1RQMI@1236|Gammaproteobacteria,464EE@72275|Alteromonadaceae 1236|Gammaproteobacteria NU Type II secretory pathway, component PulF mshG - - ko:K02505,ko:K12278 - - - - ko00000,ko02044 - - - T2SSF k59_941666_1 1131266.ARWQ01000001_gene1155 1.12e-114 337.0 COG0644@1|root,arCOG00570@2157|Archaea,41SCG@651137|Thaumarchaeota 651137|Thaumarchaeota C Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains - - - - - - - - - - - - Trp_halogenase k59_1569445_1 1247963.JPHU01000009_gene2337 2.38e-82 257.0 COG1109@1|root,COG1109@2|Bacteria,1MU24@1224|Proteobacteria,2TQWH@28211|Alphaproteobacteria 28211|Alphaproteobacteria G Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate glmM - 5.4.2.10 ko:K03431 ko00520,ko01100,ko01130,map00520,map01100,map01130 - R02060 RC00408 ko00000,ko00001,ko01000 - - - PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV k59_830327_1 316407.85675976 6.84e-116 343.0 COG2027@1|root,COG2027@2|Bacteria,1MW40@1224|Proteobacteria,1RP8V@1236|Gammaproteobacteria,3XMT9@561|Escherichia 1236|Gammaproteobacteria M D-alanyl-D-alanine carboxypeptidase dacB GO:0000003,GO:0000270,GO:0000910,GO:0003674,GO:0003824,GO:0004175,GO:0004180,GO:0004185,GO:0005488,GO:0005575,GO:0005623,GO:0006022,GO:0006026,GO:0006027,GO:0006508,GO:0006807,GO:0007049,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0008238,GO:0008360,GO:0008658,GO:0009002,GO:0009056,GO:0009057,GO:0009253,GO:0009254,GO:0009987,GO:0016043,GO:0016787,GO:0016998,GO:0017171,GO:0019538,GO:0019954,GO:0022402,GO:0022414,GO:0022603,GO:0022604,GO:0030203,GO:0030288,GO:0030313,GO:0031406,GO:0031975,GO:0032505,GO:0033218,GO:0033293,GO:0036094,GO:0042597,GO:0043093,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0044036,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044464,GO:0045229,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0051301,GO:0065007,GO:0065008,GO:0070008,GO:0070011,GO:0071554,GO:0071555,GO:0071704,GO:0071840,GO:0097159,GO:0140096,GO:1901135,GO:1901136,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901681 3.4.16.4 ko:K07259 ko00550,map00550 - - - ko00000,ko00001,ko01000,ko01002,ko01011 - - iAPECO1_1312.APECO1_3250,iECOK1_1307.ECOK1_3603,iECS88_1305.ECS88_3564,iUMN146_1321.UM146_00470,iUTI89_1310.UTI89_C3615,iYL1228.KPN_03592 Peptidase_S13 k59_544330_2 1096930.L284_23355 7.98e-21 93.6 COG4964@1|root,COG4964@2|Bacteria,1MV8G@1224|Proteobacteria,2TRNN@28211|Alphaproteobacteria,2K0ZQ@204457|Sphingomonadales 204457|Sphingomonadales U Belongs to the GSP D family cpaC - - ko:K02280 - - - - ko00000,ko02035,ko02044 - - - BON,Secretin,T2SS-T3SS_pil_N k59_941674_1 313628.LNTAR_03294 8.5e-18 78.2 COG0314@1|root,COG0314@2|Bacteria 2|Bacteria H molybdopterin synthase activity moaE GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006725,GO:0006732,GO:0006753,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009144,GO:0009150,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0016740,GO:0016782,GO:0016783,GO:0018130,GO:0019538,GO:0019637,GO:0019693,GO:0019720,GO:0030366,GO:0032324,GO:0034641,GO:0042278,GO:0043170,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046039,GO:0046128,GO:0046483,GO:0051186,GO:0051188,GO:0051189,GO:0055086,GO:0071704,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657 2.7.7.80,2.8.1.11,2.8.1.12 ko:K03635,ko:K21147 ko00790,ko01100,ko04122,map00790,map01100,map04122 - R07459,R07461,R09395 RC00043,RC02507 ko00000,ko00001,ko01000 - - - MoCF_biosynth,MoaE k59_941674_2 1276920.ADIAG_02170 6.83e-07 55.5 COG2068@1|root,COG2068@2|Bacteria,2GK5R@201174|Actinobacteria 201174|Actinobacteria NU MobA-related protein nboR - 1.1.1.328,2.7.7.76 ko:K07141,ko:K19190 ko00760,ko00790,ko01120,map00760,map00790,map01120 - R10131,R10132,R11582 RC03053 ko00000,ko00001,ko01000 - - - NTP_transf_3 k59_382274_1 1121035.AUCH01000021_gene2706 1.57e-61 196.0 COG1392@1|root,COG1392@2|Bacteria,1R4SP@1224|Proteobacteria,2VKF1@28216|Betaproteobacteria,2KW8U@206389|Rhodocyclales 206389|Rhodocyclales P Protein of unknown function DUF47 - - - ko:K07220 - - - - ko00000 - - - PhoU_div k59_433497_1 859657.RPSI07_1578 9.31e-56 192.0 COG0248@1|root,COG0248@2|Bacteria,1MV35@1224|Proteobacteria,2VI1K@28216|Betaproteobacteria,1K0ST@119060|Burkholderiaceae 28216|Betaproteobacteria FP PFAM Ppx GppA phosphatase ppx - 3.6.1.11,3.6.1.40 ko:K01524 ko00230,map00230 - R03409 RC00002 ko00000,ko00001,ko01000 - - - Ppx-GppA k59_268628_1 1123367.C666_07295 9.62e-76 236.0 COG0805@1|root,COG0805@2|Bacteria,1MVAY@1224|Proteobacteria,2VI2H@28216|Betaproteobacteria,2KUWA@206389|Rhodocyclales 206389|Rhodocyclales U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides tatC - - ko:K03118 ko03060,ko03070,map03060,map03070 M00336 - - ko00000,ko00001,ko00002,ko02044 2.A.64 - - TatC k59_1337783_1 316407.85676181 5.65e-83 263.0 COG1501@1|root,COG1501@2|Bacteria,1MWNJ@1224|Proteobacteria,1RMJ9@1236|Gammaproteobacteria,3XMXR@561|Escherichia 1236|Gammaproteobacteria G Belongs to the glycosyl hydrolase 31 family yihQ GO:0003674,GO:0003824,GO:0006066,GO:0006082,GO:0006790,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016054,GO:0016787,GO:0016798,GO:0019637,GO:0034308,GO:0042180,GO:0044237,GO:0044248,GO:0044273,GO:0044281,GO:0044282,GO:0061720,GO:0071704,GO:1901135,GO:1901136,GO:1901575,GO:1901615,GO:1902776,GO:1902777,GO:1990929 3.2.1.199 ko:K15922 - - R00802,R11543 RC00028,RC00059,RC00077,RC00451 ko00000,ko01000 - GH31 - Glyco_hydro_31 k59_490243_1 948565.AFFP02000002_gene1306 1.29e-53 178.0 COG0084@1|root,COG0084@2|Bacteria,1MUC0@1224|Proteobacteria,1RP6E@1236|Gammaproteobacteria,1Y7JW@135625|Pasteurellales 135625|Pasteurellales L Mg-dependent DNase Z012_10175 GO:0003674,GO:0003824,GO:0004518,GO:0004536,GO:0006139,GO:0006259,GO:0006308,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016787,GO:0016788,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901361,GO:1901575 - ko:K03424 - - - - ko00000,ko01000 - - - TatD_DNase k59_490243_2 1123253.AUBD01000006_gene831 3.01e-19 82.0 COG3215@1|root,COG3215@2|Bacteria,1RGWZ@1224|Proteobacteria,1S4YE@1236|Gammaproteobacteria,1X6W7@135614|Xanthomonadales 135614|Xanthomonadales NU Pilus assembly protein PilZ pilZ - - ko:K02676 - - - - ko00000,ko02035,ko02044 - - - PilZ k59_942526_1 886293.Sinac_2348 6.92e-202 577.0 COG0365@1|root,COG0365@2|Bacteria,2IX5P@203682|Planctomycetes 203682|Planctomycetes I Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA acsA - 6.2.1.1 ko:K01895 ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200 M00357 R00235,R00236,R00316,R00926,R01354 RC00004,RC00012,RC00043,RC00070,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000,ko01004 - - - ACAS_N,AMP-binding,AMP-binding_C k59_942526_2 589865.DaAHT2_1339 1.68e-73 243.0 COG0739@1|root,COG0739@2|Bacteria,1NESH@1224|Proteobacteria,42MGB@68525|delta/epsilon subdivisions,2WJ7F@28221|Deltaproteobacteria,2MI1U@213118|Desulfobacterales 28221|Deltaproteobacteria M PFAM peptidase - - - - - - - - - - - - Peptidase_M23 k59_43314_1 1123399.AQVE01000018_gene3357 2.08e-58 203.0 COG0557@1|root,COG0557@2|Bacteria,1MUS6@1224|Proteobacteria,1RMQE@1236|Gammaproteobacteria,45ZQ7@72273|Thiotrichales 72273|Thiotrichales J 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs rnr - - ko:K12573 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03016,ko03019 - - - HTH_12,OB_RNB,RNB,S1 k59_1337784_1 190650.CC_2035 1.84e-168 489.0 COG1331@1|root,COG1331@2|Bacteria,1R570@1224|Proteobacteria,2TUBQ@28211|Alphaproteobacteria,2KFKA@204458|Caulobacterales 204458|Caulobacterales O Pectic acid lyase - - - - - - - - - - - - Pec_lyase k59_1622981_1 391735.Veis_4701 1.21e-102 322.0 COG1129@1|root,COG4177@1|root,COG1129@2|Bacteria,COG4177@2|Bacteria,1R9IW@1224|Proteobacteria,2VKMT@28216|Betaproteobacteria,4AK08@80864|Comamonadaceae 28216|Betaproteobacteria P Belongs to the binding-protein-dependent transport system permease family - - - ko:K01998 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - ABC_tran,BCA_ABC_TP_C,BPD_transp_2 k59_490260_1 1415778.JQMM01000001_gene1623 9.41e-28 112.0 COG1721@1|root,COG1721@2|Bacteria,1R3QD@1224|Proteobacteria,1S5F7@1236|Gammaproteobacteria,1J60U@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S conserved protein (some members contain a von Willebrand factor type A (vWA) domain) - - - - - - - - - - - - DUF58 k59_1281265_2 1123393.KB891316_gene2013 7.98e-46 148.0 COG0025@1|root,COG0025@2|Bacteria,1QTZ5@1224|Proteobacteria,2WGIC@28216|Betaproteobacteria 28216|Betaproteobacteria P Zn-finger in ubiquitin-hydrolases and other protein - - - - - - - - - - - - zf-UBP k59_1512846_1 1227484.C471_01407 2.33e-06 50.4 COG1405@1|root,arCOG01981@2157|Archaea,2XSYE@28890|Euryarchaeota,23SMK@183963|Halobacteria 183963|Halobacteria K Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB) tfbA5 - - ko:K03124 ko03022,ko05169,ko05203,map03022,map05169,map05203 - - - ko00000,ko00001,ko03021 - - - TFIIB,TF_Zn_Ribbon k59_1512846_2 1229909.NSED_02935 1.78e-53 177.0 COG0517@1|root,arCOG00600@2157|Archaea,41TAT@651137|Thaumarchaeota 651137|Thaumarchaeota S CBS domain - - - - - - - - - - - - CBS k59_545448_1 1158292.JPOE01000002_gene1439 3.46e-192 565.0 COG0458@1|root,COG0458@2|Bacteria,1MUDZ@1224|Proteobacteria,2VI4A@28216|Betaproteobacteria,1KJ1Z@119065|unclassified Burkholderiales 28216|Betaproteobacteria F Carbamoyl-phosphate synthetase ammonia chain carB - 6.3.5.5 ko:K01955 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - - CPSase_L_D2,CPSase_L_D3,MGS k59_1227579_1 1122137.AQXF01000005_gene1306 1.37e-129 399.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2TQT0@28211|Alphaproteobacteria 28211|Alphaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_1281272_1 1454004.AW11_01126 1.7e-98 299.0 COG0056@1|root,COG0056@2|Bacteria,1MVHM@1224|Proteobacteria,2VPGJ@28216|Betaproteobacteria,1KR74@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria C ATP synthase alpha/beta chain, C terminal domain atpA2 - 3.6.3.14 ko:K02111 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - - ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N k59_545454_1 1549858.MC45_13000 7.29e-117 365.0 COG3250@1|root,COG3250@2|Bacteria,1MVBN@1224|Proteobacteria,2U222@28211|Alphaproteobacteria,2K2X5@204457|Sphingomonadales 204457|Sphingomonadales G Beta galactosidase small chain - - 3.2.1.23 ko:K01190 ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100 - R01105,R01678,R03355,R04783,R06114 RC00049,RC00452 ko00000,ko00001,ko01000 - - - Bgal_small_N,DUF4981,Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N k59_99207_1 330084.JNYZ01000043_gene1546 2.36e-29 113.0 COG1484@1|root,COG1484@2|Bacteria,2H714@201174|Actinobacteria,4E1MA@85010|Pseudonocardiales 201174|Actinobacteria L Bacterial dnaA protein - - - - - - - - - - - - IstB_IS21 k59_210996_2 1206720.BAFQ01000296_gene6644 2.17e-32 117.0 COG5637@1|root,COG5637@2|Bacteria,2GMK7@201174|Actinobacteria,4FUGY@85025|Nocardiaceae 201174|Actinobacteria S Protein involved in polyketide synthase activity and antibiotic biosynthesis - - - - - - - - - - - - Polyketide_cyc k59_326722_1 1254432.SCE1572_50505 3.01e-37 137.0 COG2197@1|root,COG2197@2|Bacteria,1R4TP@1224|Proteobacteria,42UI0@68525|delta/epsilon subdivisions,2WQIQ@28221|Deltaproteobacteria 28221|Deltaproteobacteria K Autoinducer binding domain - - - ko:K20334 ko02024,map02024 - - - ko00000,ko00001,ko03000 - - - Autoind_bind,GerE k59_490285_1 1134474.O59_001252 1.89e-09 63.2 COG2801@1|root,COG2801@2|Bacteria,1MVXQ@1224|Proteobacteria,1RR4F@1236|Gammaproteobacteria,1FHA5@10|Cellvibrio 1236|Gammaproteobacteria L hmm pf00665 - - - ko:K07497 - - - - ko00000 - - - HTH_21,rve k59_545466_1 319003.Bra1253DRAFT_03195 6.74e-104 313.0 COG0583@1|root,COG0583@2|Bacteria,1MV36@1224|Proteobacteria,2TVHU@28211|Alphaproteobacteria,3JTGW@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria K Bacterial regulatory helix-turn-helix protein, lysR family MA20_10350 - - - - - - - - - - - HTH_1,LysR_substrate k59_43348_1 402881.Plav_3077 9.22e-84 258.0 28M2T@1|root,2ZAH6@2|Bacteria,1R6GW@1224|Proteobacteria,2U25T@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_1171499_1 1229909.NSED_00400 2.88e-82 253.0 COG2132@1|root,arCOG03914@2157|Archaea,41T22@651137|Thaumarchaeota 651137|Thaumarchaeota Q Multicopper oxidase - - 1.7.2.1 ko:K00368 ko00910,ko01120,map00910,map01120 M00529 R00783,R00785 RC00086 ko00000,ko00001,ko00002,ko01000 - - - Copper-bind k59_608332_1 1088721.NSU_3981 2.29e-114 351.0 COG0642@1|root,COG0642@2|Bacteria,1QWE6@1224|Proteobacteria,2TWWP@28211|Alphaproteobacteria,2KEEF@204457|Sphingomonadales 204457|Sphingomonadales T PAS fold - - - - - - - - - - - - HATPase_c,HisKA,PAS_7 k59_1400240_1 631362.Thi970DRAFT_02509 1.5e-22 103.0 COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,1RMUR@1236|Gammaproteobacteria,1WW7H@135613|Chromatiales 135613|Chromatiales V ABC transporter transmembrane region - - - ko:K06147 - - - - ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran k59_1677931_1 1121875.KB907546_gene2365 4.21e-101 308.0 COG0624@1|root,COG0624@2|Bacteria,4NI66@976|Bacteroidetes,1HZ8W@117743|Flavobacteriia 976|Bacteroidetes E Peptidase dimerisation domain - - 3.4.17.11 ko:K01295 - - - - ko00000,ko01000,ko01002 - - - M20_dimer,Peptidase_M20,Peptidase_M28 k59_1337826_1 936572.HMPREF1148_1094 3.83e-11 68.6 COG0726@1|root,COG0726@2|Bacteria,1UYYJ@1239|Firmicutes,4H3MV@909932|Negativicutes 909932|Negativicutes G Polysaccharide deacetylase - - - - - - - - - - - - Polysacc_deac_1 k59_1512894_1 994479.GL877880_gene3989 1.29e-53 186.0 COG0187@1|root,COG0187@2|Bacteria,2GKGP@201174|Actinobacteria,4DXBM@85010|Pseudonocardiales 201174|Actinobacteria L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrB GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0003916,GO:0003918,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006265,GO:0006725,GO:0006807,GO:0006996,GO:0007059,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0009295,GO:0009987,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017076,GO:0017111,GO:0030312,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034335,GO:0034641,GO:0035639,GO:0036094,GO:0040007,GO:0042623,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0046872,GO:0051276,GO:0061505,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:0097367,GO:0140097,GO:1901265,GO:1901360,GO:1901363 5.99.1.3 ko:K02470 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim k59_1451247_1 158500.BV97_03164 2.11e-55 176.0 2FB68@1|root,343CI@2|Bacteria,1NEIW@1224|Proteobacteria,2UGH0@28211|Alphaproteobacteria,2K5XN@204457|Sphingomonadales 204457|Sphingomonadales - - - - - - - - - - - - - - - k59_211023_1 472759.Nhal_2752 6.39e-12 65.5 COG0489@1|root,COG0489@2|Bacteria,1MU7R@1224|Proteobacteria,1RMJF@1236|Gammaproteobacteria,1WX3A@135613|Chromatiales 135613|Chromatiales D Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP - - - ko:K03593 - - - - ko00000,ko03029,ko03036 - - - FeS_assembly_P,ParA k59_1512899_1 234267.Acid_3947 0.00027 48.9 COG2911@1|root,COG2911@2|Bacteria 2|Bacteria S protein secretion - - - ko:K09800 - - - - ko00000,ko02000 - - - AsmA_2,DUF748,TamB k59_490310_1 1185766.DL1_17730 6.83e-32 113.0 COG0268@1|root,COG0268@2|Bacteria,1MZ94@1224|Proteobacteria,2UC42@28211|Alphaproteobacteria,2XNPA@285107|Thioclava 28211|Alphaproteobacteria J Binds directly to 16S ribosomal RNA rpsT - - ko:K02968 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S20p k59_660976_1 85643.Tmz1t_3212 1.54e-98 291.0 COG0563@1|root,COG0563@2|Bacteria,1MXCZ@1224|Proteobacteria,2VH1C@28216|Betaproteobacteria,2KUU9@206389|Rhodocyclales 206389|Rhodocyclales F Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism adk - 2.7.4.3 ko:K00939 ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130 M00049 R00127,R01547,R11319 RC00002 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ADK,ADK_lid k59_1677947_1 1122197.ATWI01000008_gene2888 6.18e-09 56.2 COG0188@1|root,COG0188@2|Bacteria,1MURI@1224|Proteobacteria,1RMTC@1236|Gammaproteobacteria,464Q5@72275|Alteromonadaceae 1236|Gammaproteobacteria L Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule parC GO:0000819,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006265,GO:0006276,GO:0006725,GO:0006807,GO:0006996,GO:0007049,GO:0007059,GO:0007062,GO:0008150,GO:0008152,GO:0009330,GO:0009987,GO:0016020,GO:0016043,GO:0019897,GO:0019898,GO:0022402,GO:0030541,GO:0032991,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0046483,GO:0051276,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:0098813,GO:1901360,GO:1901363 - ko:K02621 - - - - ko00000,ko01000,ko02048,ko03032,ko03036 - - - DNA_gyraseA_C,DNA_topoisoIV k59_1677947_2 1121374.KB891575_gene1170 1.56e-124 373.0 COG0187@1|root,COG0187@2|Bacteria,1MVH1@1224|Proteobacteria,1RMCI@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule parE - - ko:K02622 - - - - ko00000,ko01000,ko02048,ko03032,ko03036 - - - DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim k59_1623029_1 1415778.JQMM01000001_gene262 8.47e-61 197.0 COG2981@1|root,COG2981@2|Bacteria,1MVFT@1224|Proteobacteria,1RMQT@1236|Gammaproteobacteria,1J5RJ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria U High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway cysZ GO:0000096,GO:0000097,GO:0000103,GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006082,GO:0006520,GO:0006534,GO:0006790,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0008150,GO:0008152,GO:0008271,GO:0008272,GO:0008324,GO:0008509,GO:0008512,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009675,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015103,GO:0015116,GO:0015291,GO:0015293,GO:0015294,GO:0015295,GO:0015296,GO:0015318,GO:0015672,GO:0015698,GO:0016020,GO:0016021,GO:0016053,GO:0019344,GO:0019752,GO:0022804,GO:0022857,GO:0022890,GO:0031224,GO:0031226,GO:0034220,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044425,GO:0044459,GO:0044464,GO:0046394,GO:0051179,GO:0051234,GO:0055085,GO:0071704,GO:0071944,GO:0072348,GO:0098655,GO:0098656,GO:0098660,GO:0098661,GO:0098662,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1901682,GO:1902358,GO:1902600 - ko:K06203 - - - - ko00000 - - iJR904.b2413,iYL1228.KPN_02760 EI24 k59_1281300_2 1229909.NSED_04950 2.61e-182 516.0 COG1503@1|root,arCOG01742@2157|Archaea,41SEK@651137|Thaumarchaeota 651137|Thaumarchaeota J Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA prf1 - - ko:K03265 ko03015,map03015 - - - ko00000,ko00001,ko03012,ko03019 - - - eRF1_1,eRF1_2,eRF1_3 k59_1171537_2 1380394.JADL01000001_gene3032 1.54e-35 128.0 COG0625@1|root,COG0625@2|Bacteria,1RHSK@1224|Proteobacteria,2U5GF@28211|Alphaproteobacteria,2JSRE@204441|Rhodospirillales 204441|Rhodospirillales O Glutathione S-transferase - - - - - - - - - - - - GST_C_2,GST_N_3 k59_1059776_1 583345.Mmol_1395 7.57e-32 131.0 COG2204@1|root,COG4963@1|root,COG2204@2|Bacteria,COG4963@2|Bacteria,1MWNY@1224|Proteobacteria,2VNYQ@28216|Betaproteobacteria,2KNDN@206350|Nitrosomonadales 206350|Nitrosomonadales D Cellulose biosynthesis protein BcsQ - - - ko:K02282 - - - - ko00000,ko02035,ko02044 - - - AAA_31,Response_reg k59_1059776_2 335543.Sfum_1498 3.36e-177 511.0 COG4962@1|root,COG4962@2|Bacteria,1R7EN@1224|Proteobacteria,42NAK@68525|delta/epsilon subdivisions,2WIYX@28221|Deltaproteobacteria,2MQ42@213462|Syntrophobacterales 28221|Deltaproteobacteria U PFAM Type II secretion system protein E - - - ko:K02283,ko:K03609 - - - - ko00000,ko02035,ko02044,ko03036,ko04812 - - - CbiA,FHA,T2SSE k59_1570427_1 998674.ATTE01000001_gene3700 3.1e-17 83.2 COG3245@1|root,COG3245@2|Bacteria,1MZBZ@1224|Proteobacteria,1S9Z9@1236|Gammaproteobacteria,4618P@72273|Thiotrichales 72273|Thiotrichales C Cytochrome C oxidase, cbb3-type, subunit III - - - - - - - - - - - - Cytochrome_CBB3 k59_211038_1 1163617.SCD_n02706 4.71e-75 238.0 COG1797@1|root,COG1797@2|Bacteria,1MV7Z@1224|Proteobacteria,2VI93@28216|Betaproteobacteria 28216|Betaproteobacteria H Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source cbiA - 6.3.5.11,6.3.5.9 ko:K02224 ko00860,ko01100,ko01120,map00860,map01100,map01120 - R05224,R05815 RC00010,RC01301 ko00000,ko00001,ko01000 - - - AAA_26,CbiA,GATase_3 k59_1112603_2 1415778.JQMM01000001_gene1135 2.43e-93 283.0 COG2304@1|root,COG2304@2|Bacteria,1QBPM@1224|Proteobacteria,1RQIU@1236|Gammaproteobacteria,1J4PZ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Secreted protein, containing von Willebrand factor (VWF) type - - - - - - - - - - - - - k59_721761_1 1123399.AQVE01000011_gene1231 3.73e-77 251.0 COG1529@1|root,COG1529@2|Bacteria,1QTTJ@1224|Proteobacteria,1RNCM@1236|Gammaproteobacteria,45ZUE@72273|Thiotrichales 72273|Thiotrichales C Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain - - 1.3.99.16 ko:K07303 - - - - ko00000,ko01000 - - - Ald_Xan_dh_C,Ald_Xan_dh_C2 k59_772689_1 998674.ATTE01000001_gene2520 2.2e-71 221.0 COG1347@1|root,COG1347@2|Bacteria,1MUZR@1224|Proteobacteria,1RNFE@1236|Gammaproteobacteria,4602B@72273|Thiotrichales 72273|Thiotrichales C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol nqrD - 1.6.5.8 ko:K00349 - - - - ko00000,ko01000 - - - Rnf-Nqr k59_772689_2 1397527.Q670_16480 4.06e-06 47.8 COG2869@1|root,COG2869@2|Bacteria,1MVDI@1224|Proteobacteria,1RR85@1236|Gammaproteobacteria,1XH23@135619|Oceanospirillales 135619|Oceanospirillales C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol nqrC - 1.6.5.8 ko:K00348 - - - - ko00000,ko01000 - - - FMN_bind k59_1281323_1 234267.Acid_0469 6.01e-82 265.0 COG1506@1|root,COG1506@2|Bacteria,3Y3DT@57723|Acidobacteria 57723|Acidobacteria E peptidase S9B dipeptidylpeptidase IV domain protein - - - - - - - - - - - - DPPIV_N,Peptidase_S9 k59_99260_1 436308.Nmar_1085 4.55e-76 251.0 COG0458@1|root,arCOG01594@2157|Archaea,41SBF@651137|Thaumarchaeota 651137|Thaumarchaeota E MGS-like domain - - 6.3.5.5 ko:K01955 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - - CPSase_L_D2,CPSase_L_D3,MGS k59_608378_1 643562.Daes_2758 8.26e-49 169.0 COG0601@1|root,COG0601@2|Bacteria,1NS80@1224|Proteobacteria,42N5D@68525|delta/epsilon subdivisions,2WIRR@28221|Deltaproteobacteria,2M81K@213115|Desulfovibrionales 28221|Deltaproteobacteria P PFAM binding-protein-dependent transport systems inner membrane component - - - ko:K02033 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1 k59_1623060_2 1049564.TevJSym_at00460 0.000495 42.7 COG4973@1|root,COG4973@2|Bacteria,1MUJJ@1224|Proteobacteria,1RMJG@1236|Gammaproteobacteria,1J4JX@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria D Belongs to the 'phage' integrase family. XerC subfamily xerC GO:0000150,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006276,GO:0006310,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008907,GO:0009009,GO:0009037,GO:0009987,GO:0015074,GO:0032991,GO:0034641,GO:0042150,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0048476,GO:0071139,GO:0071704,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363 - ko:K03733 - - - - ko00000,ko03036 - - - Phage_int_SAM_1,Phage_integrase k59_721788_1 648885.KB316283_gene4109 1.17e-53 184.0 COG0260@1|root,COG0260@2|Bacteria,1MUIN@1224|Proteobacteria,2TSI6@28211|Alphaproteobacteria,1JR1H@119045|Methylobacteriaceae 28211|Alphaproteobacteria E Belongs to the peptidase M17 family pepA - 3.4.11.1 ko:K01255 ko00480,ko01100,map00480,map01100 - R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 - - - Peptidase_M17 k59_268696_1 316407.1742368 3.2e-29 114.0 COG3209@1|root,COG3209@2|Bacteria,1NG5W@1224|Proteobacteria 1224|Proteobacteria M COG3209 Rhs family protein - - - - - - - - - - - - RHS k59_721791_1 1121875.KB907547_gene3097 6.82e-45 165.0 COG1629@1|root,COG4771@2|Bacteria,4P1Z5@976|Bacteroidetes,1I04A@117743|Flavobacteriia 976|Bacteroidetes P Outer membrane receptor - - - - - - - - - - - - CarbopepD_reg_2,Plug,TonB_dep_Rec k59_1112624_1 1120966.AUBU01000006_gene3357 2.13e-29 121.0 COG0591@1|root,COG5002@1|root,COG0591@2|Bacteria,COG5002@2|Bacteria,4PNA5@976|Bacteroidetes,47JPD@768503|Cytophagia 976|Bacteroidetes ET His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA k59_1112624_2 391587.KAOT1_21457 3.82e-16 72.4 COG0745@1|root,COG0745@2|Bacteria,4NP5C@976|Bacteroidetes,1I24M@117743|Flavobacteriia 976|Bacteroidetes T transcriptional regulator - - - - - - - - - - - - Response_reg k59_998710_1 59196.RICGR_0467 5.43e-57 193.0 COG0305@1|root,COG3598@1|root,COG0305@2|Bacteria,COG3598@2|Bacteria,1QVBD@1224|Proteobacteria,1SJFV@1236|Gammaproteobacteria 1236|Gammaproteobacteria L AAA domain - - - - - - - - - - - - AAA_25,DnaB k59_661024_1 472175.EL18_02467 9.35e-29 110.0 COG0622@1|root,COG0622@2|Bacteria,1RGUN@1224|Proteobacteria,2U848@28211|Alphaproteobacteria,43PZU@69277|Phyllobacteriaceae 28211|Alphaproteobacteria S Calcineurin-like phosphoesterase superfamily domain - - - ko:K07095 - - - - ko00000 - - - Metallophos_2 k59_153816_1 1122143.AUEG01000002_gene714 1.85e-12 67.8 COG4961@1|root,COG4961@2|Bacteria,1TZPI@1239|Firmicutes,4HRXM@91061|Bacilli 91061|Bacilli U TadE-like protein - - - - - - - - - - - - TadE k59_1677995_1 697282.Mettu_0388 2.1e-71 224.0 COG1796@1|root,COG1796@2|Bacteria,1QF8Z@1224|Proteobacteria,1RRQ5@1236|Gammaproteobacteria,1XH0H@135618|Methylococcales 135618|Methylococcales L Helix-hairpin-helix domain - - - - - - - - - - - - HHH_5,HHH_8 k59_334290_1 1144305.PMI02_05230 3.25e-52 171.0 COG1182@1|root,COG1182@2|Bacteria,1P59R@1224|Proteobacteria,2U8Z1@28211|Alphaproteobacteria,2K4NI@204457|Sphingomonadales 204457|Sphingomonadales I Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity azoR - - ko:K01118 - - - - ko00000,ko01000 - - - Flavodoxin_2 k59_616429_1 709797.CSIRO_4259 4.52e-09 59.7 COG0643@1|root,COG2198@1|root,COG0643@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,2TSN2@28211|Alphaproteobacteria,3JTYN@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria T Function of homologous gene experimentally demonstrated in an other organism cheA - 2.7.13.3 ko:K03407 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 - - - CheW,H-kinase_dim,HATPase_c,Hpt,Response_reg k59_616429_2 1123355.JHYO01000007_gene479 3.84e-30 114.0 COG0835@1|root,COG0835@2|Bacteria,1RAH1@1224|Proteobacteria,2U59Y@28211|Alphaproteobacteria,36YI4@31993|Methylocystaceae 28211|Alphaproteobacteria NT Two component signalling adaptor domain cheW - - ko:K03408 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - CheW k59_442327_1 469381.Dpep_1197 7.04e-32 122.0 COG1540@1|root,COG1540@2|Bacteria,3T9Q0@508458|Synergistetes 508458|Synergistetes S Belongs to the UPF0271 (lamB) family - - - ko:K07160 - - - - ko00000 - - - LamB_YcsF k59_668622_1 497964.CfE428DRAFT_1082 1.26e-65 218.0 COG1222@1|root,COG1222@2|Bacteria,46UBC@74201|Verrucomicrobia 74201|Verrucomicrobia O Proteasomal ATPase OB/ID domain - - - ko:K13527 ko03050,map03050 M00342 - - ko00000,ko00001,ko00002,ko03051 - - - AAA,Prot_ATP_ID_OB k59_1234890_1 436308.Nmar_1103 1.59e-97 298.0 COG0322@1|root,arCOG04753@2157|Archaea,41SX9@651137|Thaumarchaeota 651137|Thaumarchaeota L TIGRFAM excinuclease ABC, C subunit - - - ko:K03703 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - GIY-YIG,UVR,UvrC_HhH_N k59_497676_1 765910.MARPU_11570 2.06e-70 221.0 COG0492@1|root,COG0492@2|Bacteria,1MV15@1224|Proteobacteria,1RMEX@1236|Gammaproteobacteria,1WWPK@135613|Chromatiales 135613|Chromatiales C Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family - - 1.8.1.9 ko:K00384 ko00450,map00450 - R02016,R03596,R09372 RC00013,RC02518,RC02873 ko00000,ko00001,ko01000 - - - Pyr_redox_2 k59_1743254_2 1408813.AYMG01000039_gene2287 9.82e-35 130.0 2EC2B@1|root,3361E@2|Bacteria,4P2XW@976|Bacteroidetes 976|Bacteroidetes - - - - - - - - - - - - - - - k59_899700_1 1122137.AQXF01000006_gene678 4.61e-131 405.0 COG0457@1|root,COG0457@2|Bacteria,1N09H@1224|Proteobacteria,2TSKT@28211|Alphaproteobacteria 28211|Alphaproteobacteria K Tetratricopeptide repeat - - - - - - - - - - - - - k59_899701_1 1121374.KB891586_gene2527 1.65e-155 457.0 COG0376@1|root,COG0376@2|Bacteria,1MUBF@1224|Proteobacteria,1RNA5@1236|Gammaproteobacteria 1236|Gammaproteobacteria P Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity katG GO:0000302,GO:0003674,GO:0003824,GO:0004096,GO:0004601,GO:0005488,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009636,GO:0009987,GO:0010035,GO:0016209,GO:0016491,GO:0016684,GO:0016999,GO:0017001,GO:0017144,GO:0020037,GO:0033554,GO:0034599,GO:0034614,GO:0035690,GO:0042221,GO:0042493,GO:0042542,GO:0042737,GO:0042743,GO:0042744,GO:0044237,GO:0044248,GO:0044424,GO:0044444,GO:0044464,GO:0046677,GO:0046906,GO:0048037,GO:0050896,GO:0051186,GO:0051187,GO:0051716,GO:0055114,GO:0070301,GO:0070887,GO:0071236,GO:0072593,GO:0097159,GO:0097237,GO:0098754,GO:0098869,GO:1901363,GO:1901700,GO:1901701,GO:1990748 1.11.1.21 ko:K03782 ko00360,ko00380,ko00940,ko00983,ko01100,ko01110,map00360,map00380,map00940,map00983,map01100,map01110 - R00602,R00698,R02596,R02670,R03919,R04007,R07443,R11906 RC00034,RC00213,RC00767,RC02141 ko00000,ko00001,ko01000 - - - peroxidase k59_899704_1 1236541.BALL01000045_gene4083 8.69e-05 45.1 COG0460@1|root,COG0527@1|root,COG0460@2|Bacteria,COG0527@2|Bacteria,1MW3H@1224|Proteobacteria,1RN1G@1236|Gammaproteobacteria,2Q9VU@267890|Shewanellaceae 1236|Gammaproteobacteria E PFAM aspartate glutamate uridylate kinase metL GO:0003674,GO:0003824,GO:0004072,GO:0004412,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006553,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009070,GO:0009085,GO:0009089,GO:0009090,GO:0009092,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016491,GO:0016614,GO:0016616,GO:0016740,GO:0016772,GO:0016774,GO:0019202,GO:0019752,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.3,2.7.2.4 ko:K12524,ko:K12525 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00017,M00018,M00526,M00527 R00480,R01773,R01775 RC00002,RC00043,RC00087 ko00000,ko00001,ko00002,ko01000 - - iUMNK88_1353.UMNK88_4778,iYL1228.KPN_04234 AA_kinase,ACT_7,Homoserine_dh,NAD_binding_3 k59_899704_2 1007103.AFHW01000056_gene5445 4.12e-07 51.6 COG3191@1|root,COG3191@2|Bacteria,1TQHA@1239|Firmicutes,4HAZM@91061|Bacilli,26V0Q@186822|Paenibacillaceae 91061|Bacilli EQ Peptidase family S58 - - 3.4.11.19 ko:K01266 - - - - ko00000,ko01000,ko01002 - - - Peptidase_S58 k59_1408395_1 316407.85676121 4.34e-117 343.0 COG0626@1|root,COG0626@2|Bacteria,1MU57@1224|Proteobacteria,1RMCV@1236|Gammaproteobacteria,3XNGS@561|Escherichia 1236|Gammaproteobacteria E Catalyzes the formation of L-cystathionine from O- succinyl-L-homoserine (OSHS) and L-cysteine, via a gamma- replacement reaction. In the absence of thiol, catalyzes gamma- elimination to form 2-oxobutanoate, succinate and ammonia metB GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0003962,GO:0004123,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0016829,GO:0016846,GO:0019752,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.5.1.48 ko:K01739 ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00270,map00450,map00920,map01100,map01110,map01130,map01230 M00017 R00999,R01288,R02508,R03217,R03260,R04944,R04945,R04946 RC00020,RC00056,RC00069,RC00420,RC02848,RC02866 ko00000,ko00001,ko00002,ko01000 - - iAF1260.b3939,iBWG_1329.BWG_3608,iECDH10B_1368.ECDH10B_4128,iECDH1ME8569_1439.ECDH1ME8569_3808,iETEC_1333.ETEC_4208,iEcDH1_1363.EcDH1_4046,iEcHS_1320.EcHS_A4172,iEcolC_1368.EcolC_4076,iJO1366.b3939,iJR904.b3939,iUMNK88_1353.UMNK88_4777,iUTI89_1310.UTI89_C4524,iY75_1357.Y75_RS17365 Cys_Met_Meta_PP k59_51058_1 1122137.AQXF01000001_gene2893 1.41e-108 330.0 COG0204@1|root,COG0204@2|Bacteria,1MWDY@1224|Proteobacteria,2TTGI@28211|Alphaproteobacteria 28211|Alphaproteobacteria IQ Major facilitator Superfamily aas - 2.3.1.40,6.2.1.20 ko:K05939 ko00071,ko00564,map00071,map00564 - R01406,R04864 RC00014,RC00039,RC00041 ko00000,ko00001,ko01000 - - - AMP-binding,Acyltransferase,MFS_1 k59_1408425_1 639030.JHVA01000001_gene172 5.41e-47 170.0 COG1132@1|root,COG1132@2|Bacteria,3Y2ZR@57723|Acidobacteria,2JHJA@204432|Acidobacteriia 204432|Acidobacteriia V ABC transporter, transmembrane - - - ko:K18890 ko02010,map02010 M00707 - - ko00000,ko00001,ko00002,ko02000 3.A.1.106.13,3.A.1.106.5 - - ABC_membrane,ABC_tran k59_1578268_1 1101190.ARWB01000001_gene3506 1.6e-95 303.0 COG2609@1|root,COG2609@2|Bacteria,1MV21@1224|Proteobacteria,2TSZ9@28211|Alphaproteobacteria 28211|Alphaproteobacteria C Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) aceE - 1.2.4.1 ko:K00163 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200 M00307 R00014,R00209,R01699,R03270 RC00004,RC00027,RC00627,RC02742,RC02744,RC02882 br01601,ko00000,ko00001,ko00002,ko01000 - - - Biotin_lipoyl,Transketolase_N k59_107116_1 585425.KR52_01200 3.64e-107 324.0 COG0065@1|root,COG0065@2|Bacteria,1G1J0@1117|Cyanobacteria,1GZ9E@1129|Synechococcus 1117|Cyanobacteria H Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate leuC - 4.2.1.33,4.2.1.35 ko:K01703 ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230 M00432,M00535 R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170 RC00497,RC00976,RC00977,RC01041,RC01046,RC03072 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase k59_107116_2 203908.EGG01925 0.000488 44.3 COG0065@1|root,KOG0454@2759|Eukaryota,38DTW@33154|Opisthokonta,3NUV6@4751|Fungi,3UY8V@5204|Basidiomycota,2YC4I@29000|Pucciniomycotina 4751|Fungi E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate LEU1 GO:0003674,GO:0003824,GO:0003861,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009987,GO:0010494,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0019752,GO:0032991,GO:0035770,GO:0036464,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1990904 4.2.1.33 ko:K01702 ko00290,ko01100,ko01110,ko01210,ko01230,map00290,map01100,map01110,map01210,map01230 M00432 R03968,R04001,R10170 RC01041,RC01046,RC03072 br01601,ko00000,ko00001,ko00002,ko01000 - - iMM904.YGL009C,iND750.YGL009C Aconitase,Aconitase_C k59_276718_1 338966.Ppro_0848 5.19e-17 79.3 COG0356@1|root,COG0356@2|Bacteria,1MV87@1224|Proteobacteria,42NZS@68525|delta/epsilon subdivisions,2WINI@28221|Deltaproteobacteria 28221|Deltaproteobacteria C it plays a direct role in the translocation of protons across the membrane - - - ko:K02108 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko03110 3.A.2.1 - - ATP-synt_A k59_276718_2 297246.lpp2330 9.92e-28 103.0 2E70X@1|root,331JP@2|Bacteria,1N81S@1224|Proteobacteria,1SCI0@1236|Gammaproteobacteria,1JEP9@118969|Legionellales 118969|Legionellales S Putative F0F1-ATPase subunit Ca2+/Mg2+ transporter - - - ko:K02116 - - - - ko00000,ko00194 3.A.2.1 - - ATPase_gene1 k59_334326_1 1380394.JADL01000013_gene591 7.05e-15 73.9 COG1319@1|root,COG1319@2|Bacteria,1RCRH@1224|Proteobacteria,2TU08@28211|Alphaproteobacteria,2JR4W@204441|Rhodospirillales 204441|Rhodospirillales C CO dehydrogenase flavoprotein C-terminal domain - - - - - - - - - - - - CO_deh_flav_C,FAD_binding_5 k59_334326_2 388399.SSE37_05802 1.13e-80 242.0 COG2080@1|root,COG2080@2|Bacteria,1RB3F@1224|Proteobacteria,2VF0C@28211|Alphaproteobacteria 28211|Alphaproteobacteria C COG2080 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS CutS homologs - - 1.2.5.3 ko:K03518 - - R11168 RC02800 ko00000,ko01000 - - - Fer2,Fer2_2 k59_334326_3 247633.GP2143_17331 2.49e-21 92.8 COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,1RN40@1236|Gammaproteobacteria,1J9VK@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C COG1529 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL CutL homologs yagR GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016903,GO:0030151,GO:0033554,GO:0042597,GO:0043167,GO:0043169,GO:0044464,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0055114 1.17.1.4 ko:K11177 ko00230,ko01100,ko01120,map00230,map01100,map01120 M00546 R01768,R02103 RC00143 ko00000,ko00001,ko00002,ko01000 - - - Ald_Xan_dh_C,Ald_Xan_dh_C2 k59_161575_2 1123354.AUDR01000012_gene1646 1.07e-61 199.0 COG0745@1|root,COG0745@2|Bacteria,1N0YI@1224|Proteobacteria,2VHIS@28216|Betaproteobacteria,1KRJY@119069|Hydrogenophilales 119069|Hydrogenophilales T Transcriptional regulatory protein, C terminal - - - ko:K07666 ko02020,ko02024,map02020,map02024 M00453 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Trans_reg_C k59_553397_2 1123237.Salmuc_02631 3.12e-16 79.3 COG2010@1|root,COG2010@2|Bacteria,1QXW0@1224|Proteobacteria,2TXCX@28211|Alphaproteobacteria 2|Bacteria C COG2010 Cytochrome c, mono- and diheme variants - - - - - - - - - - - - Cytochrom_C,Cytochrome_CBB3 k59_553397_3 1382306.JNIM01000001_gene195 9.11e-21 94.4 COG0309@1|root,COG0309@2|Bacteria,2G5MV@200795|Chloroflexi 200795|Chloroflexi O hydrogenase expression formation protein HypE hypE - - ko:K04655 - - - - ko00000 - - - AIRS,AIRS_C k59_1345760_1 1288494.EBAPG3_19700 6.42e-22 94.0 COG0578@1|root,COG0578@2|Bacteria,1MUMY@1224|Proteobacteria,2VN8I@28216|Betaproteobacteria,372VF@32003|Nitrosomonadales 28216|Betaproteobacteria C PFAM FAD dependent oxidoreductase glpD - 1.1.5.3 ko:K00111 ko00564,ko01110,map00564,map01110 - R00848 RC00029 ko00000,ko00001,ko01000 - - - DAO,DAO_C k59_276725_2 1122137.AQXF01000004_gene1655 7.83e-74 239.0 COG1283@1|root,COG1283@2|Bacteria,1MUDE@1224|Proteobacteria,2TRF9@28211|Alphaproteobacteria 28211|Alphaproteobacteria P Na phosphate symporter - - - ko:K03324 - - - - ko00000,ko02000 2.A.58.2 - - Na_Pi_cotrans k59_1067449_1 1122137.AQXF01000001_gene3041 1.25e-121 367.0 COG0744@1|root,COG0744@2|Bacteria,1QTST@1224|Proteobacteria,2TQQ8@28211|Alphaproteobacteria 28211|Alphaproteobacteria M penicillin-binding protein pbpC - 2.4.1.129,3.4.16.4 ko:K05366 ko00550,ko01100,ko01501,map00550,map01100,map01501 - - - ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 - Transgly,Transpeptidase k59_442418_1 1122137.AQXF01000006_gene939 1.26e-99 297.0 COG0564@1|root,COG0564@2|Bacteria,1MVDX@1224|Proteobacteria,2TTQC@28211|Alphaproteobacteria 28211|Alphaproteobacteria J Responsible for synthesis of pseudouridine from uracil rluC GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360 5.4.99.24 ko:K06179 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2,S4 k59_1179165_1 1123393.KB891326_gene83 9.79e-98 302.0 COG1387@1|root,COG1387@2|Bacteria,1MYXV@1224|Proteobacteria,2VJIQ@28216|Betaproteobacteria,1KSJ5@119069|Hydrogenophilales 119069|Hydrogenophilales L DNA polymerase X family - - - ko:K02347 - - - - ko00000,ko03400 - - - DNA_pol_B_thumb,HHH_5,HHH_8 k59_442429_1 1122137.AQXF01000001_gene2795 8.15e-80 246.0 COG0647@1|root,COG0647@2|Bacteria,1MU9Y@1224|Proteobacteria,2TUH0@28211|Alphaproteobacteria 28211|Alphaproteobacteria G sugar phosphatases of the HAD superfamily - - - - - - - - - - - - Hydrolase_6,Hydrolase_like k59_1520708_2 298653.Franean1_4697 5.24e-53 183.0 COG1012@1|root,COG1012@2|Bacteria 2|Bacteria C belongs to the aldehyde dehydrogenase family luxC - 1.2.1.50 ko:K03400 ko02020,ko02024,map02020,map02024 - R10549 RC00004,RC00184 ko00000,ko00001,ko01000 - - - LuxC k59_553430_1 1454004.AW11_00376 1.25e-21 90.1 COG0745@1|root,COG0745@2|Bacteria,1MU3A@1224|Proteobacteria,2VJTG@28216|Betaproteobacteria 28216|Betaproteobacteria K Pfam Response regulator receiver - - - - - - - - - - - - Response_reg,Trans_reg_C k59_553430_2 1265505.ATUG01000001_gene3624 6.97e-33 126.0 COG0642@1|root,COG2205@2|Bacteria,1QUJ7@1224|Proteobacteria,43BJF@68525|delta/epsilon subdivisions,2WU4G@28221|Deltaproteobacteria,2MMQM@213118|Desulfobacterales 28221|Deltaproteobacteria T HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - - - - - - - - - - - HATPase_c,HisKA k59_161606_1 595537.Varpa_5203 5.65e-22 94.7 COG2823@1|root,COG2823@2|Bacteria,1N42J@1224|Proteobacteria,2VK5B@28216|Betaproteobacteria,4AHC6@80864|Comamonadaceae 28216|Betaproteobacteria F Cytidylate kinase-like family - - - - - - - - - - - - BON,Cytidylate_kin2 k59_1120245_2 45351.EDO38471 1.21e-06 54.3 KOG3649@1|root,KOG3649@2759|Eukaryota,39TKW@33154|Opisthokonta,3BKG3@33208|Metazoa 33208|Metazoa S Kazal-type serine protease inhibitor domain - GO:0003674,GO:0004857,GO:0004866,GO:0004867,GO:0005488,GO:0005575,GO:0005576,GO:0005615,GO:0005622,GO:0005623,GO:0005737,GO:0005783,GO:0008150,GO:0009719,GO:0009725,GO:0009892,GO:0010033,GO:0010466,GO:0010605,GO:0010951,GO:0012505,GO:0014070,GO:0019222,GO:0019863,GO:0019864,GO:0019865,GO:0030162,GO:0030234,GO:0030246,GO:0030414,GO:0031323,GO:0031324,GO:0032268,GO:0032269,GO:0032991,GO:0033993,GO:0042221,GO:0043086,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044092,GO:0044421,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0045861,GO:0048519,GO:0048523,GO:0048545,GO:0050789,GO:0050790,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0051336,GO:0051346,GO:0052547,GO:0052548,GO:0060255,GO:0061134,GO:0061135,GO:0065007,GO:0065009,GO:0080090,GO:0098772 - - - - - - - - - - Kazal_1 k59_1006174_2 1229909.NSED_08860 7.96e-102 301.0 COG1756@1|root,arCOG04122@2157|Archaea,41T2T@651137|Thaumarchaeota 651137|Thaumarchaeota J Methyltransferase involved in ribosomal biogenesis. Specifically catalyzes the N1-methylation of the pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA nep1 - 2.1.1.260 ko:K14568 ko03008,map03008 - - - ko00000,ko00001,ko01000,ko03009 - - - EMG1 k59_1179201_1 402777.KB235904_gene3680 4.01e-55 196.0 COG1020@1|root,COG1020@2|Bacteria,1G0XE@1117|Cyanobacteria,1H6ZY@1150|Oscillatoriales 1117|Cyanobacteria Q non-ribosomal peptide synthetase - - - - - - - - - - - - AMP-binding,AMP-binding_C,Condensation,Methyltransf_11,Methyltransf_12,Methyltransf_25,Methyltransf_31,PP-binding,Thioesterase k59_1067480_1 316407.85674916 4.21e-194 539.0 COG0037@1|root,COG0037@2|Bacteria,1MW5Q@1224|Proteobacteria,1RN2H@1236|Gammaproteobacteria,3XP9A@561|Escherichia 1236|Gammaproteobacteria J Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32). The sulfur atoms are provided by the cysteine cysteine desulfurase (IscS) system ttcA GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016782,GO:0016783,GO:0034227,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0071704,GO:0090304,GO:1901360 - ko:K14058 - - - - ko00000,ko03016 - - - ATP_bind_3 k59_107181_1 105559.Nwat_0275 4.37e-57 189.0 COG1420@1|root,COG1420@2|Bacteria,1MVX4@1224|Proteobacteria,1RR2F@1236|Gammaproteobacteria,1WXB7@135613|Chromatiales 135613|Chromatiales K Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons hrcA - - ko:K03705 - - - - ko00000,ko03000 - - - HrcA,HrcA_DNA-bdg k59_1067490_1 1041930.Mtc_0615 1.43e-30 124.0 COG0438@1|root,arCOG01411@2157|Archaea 2157|Archaea M PFAM Glycosyl transferases group 1 - - - - - - - - - - - - Glyco_transf_4,Glycos_transf_1 k59_391615_1 187272.Mlg_0887 6.43e-32 113.0 COG0335@1|root,COG0335@2|Bacteria,1RH3A@1224|Proteobacteria,1S5XX@1236|Gammaproteobacteria,1WYID@135613|Chromatiales 135613|Chromatiales J This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site rplS - - ko:K02884 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L19 k59_391615_2 580332.Slit_0818 4.18e-26 105.0 COG5660@1|root,2Z7TM@2|Bacteria,1PMCV@1224|Proteobacteria,2VWPY@28216|Betaproteobacteria 28216|Betaproteobacteria S TRAP transporter T-component - - - - - - - - - - - - TAtT k59_276765_2 1122137.AQXF01000004_gene1810 2.54e-50 162.0 2CCMQ@1|root,32RW3@2|Bacteria,1MZHB@1224|Proteobacteria,2UCC9@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Protein of unknown function (DUF2794) MA20_43795 - - - - - - - - - - - DUF2794 k59_276765_3 1122137.AQXF01000004_gene1811 5.84e-23 97.1 COG3595@1|root,COG3595@2|Bacteria,1N8NB@1224|Proteobacteria,2TZMI@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Putative auto-transporter adhesin, head GIN domain - - - - - - - - - - - - DUF2807 k59_1234992_1 314287.GB2207_01252 1.88e-88 273.0 COG1752@1|root,COG1752@2|Bacteria,1PDQ2@1224|Proteobacteria,1RMWI@1236|Gammaproteobacteria,1J54S@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S esterase of the alpha-beta hydrolase superfamily - - - ko:K07001 - - - - ko00000 - - - Patatin k59_442467_1 1229780.BN381_80297 1.16e-08 55.5 COG0595@1|root,COG0595@2|Bacteria,2GIW7@201174|Actinobacteria,3UW71@52018|unclassified Actinobacteria (class) 201174|Actinobacteria J An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay rnj GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004527,GO:0004532,GO:0004534,GO:0004540,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008409,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016787,GO:0016788,GO:0016796,GO:0016896,GO:0022613,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0090503,GO:0140098,GO:1901360 - ko:K12574 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - Lactamase_B,Lactamase_B_2,RMMBL k59_442467_2 180281.CPCC7001_2102 1.31e-32 124.0 COG0329@1|root,COG0329@2|Bacteria,1G0HP@1117|Cyanobacteria,22RWX@167375|Cyanobium 1117|Cyanobacteria E Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) dapA - 4.3.3.7 ko:K01714 ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R10147 RC03062,RC03063 ko00000,ko00001,ko00002,ko01000 - - - DHDPS k59_218753_1 469617.FUAG_01242 5.59e-25 100.0 COG1525@1|root,COG1525@2|Bacteria,37AR9@32066|Fusobacteria 32066|Fusobacteria L K01174 micrococcal nuclease - - 3.1.31.1 ko:K01174 - - - - ko00000,ko01000 - - - SNase k59_1743371_1 1172188.KB911824_gene3300 3.74e-19 87.0 COG3860@1|root,COG3860@2|Bacteria,2HXJ0@201174|Actinobacteria,4FH44@85021|Intrasporangiaceae 201174|Actinobacteria S Uncharacterized protein conserved in bacteria (DUF2087) - - - - - - - - - - - - DUF2087 k59_107223_1 1122194.AUHU01000004_gene1322 3.59e-121 357.0 COG0389@1|root,COG0389@2|Bacteria,1MUUH@1224|Proteobacteria,1RMFM@1236|Gammaproteobacteria,464UA@72275|Alteromonadaceae 1236|Gammaproteobacteria L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII dinB GO:0003674,GO:0003824,GO:0003887,GO:0006139,GO:0006259,GO:0006260,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:0140097,GO:1901360,GO:1901362,GO:1901576 2.7.7.7 ko:K02346 - - - - ko00000,ko01000,ko03400 - - - IMS,IMS_C,IMS_HHH k59_1289665_1 314287.GB2207_08236 1.68e-63 198.0 COG1495@1|root,COG1495@2|Bacteria,1RIJE@1224|Proteobacteria,1S6WD@1236|Gammaproteobacteria,1J6DM@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein dsbB - - ko:K03611 - - - - ko00000,ko03110 5.A.2.1 - - DsbB k59_51160_1 1134474.O59_003725 1.4e-61 200.0 COG1995@1|root,COG1995@2|Bacteria,1MX5W@1224|Proteobacteria,1RNZV@1236|Gammaproteobacteria,1FFTZ@10|Cellvibrio 1236|Gammaproteobacteria H Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) pdxA GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006081,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008614,GO:0008615,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0034641,GO:0036094,GO:0042364,GO:0042802,GO:0042816,GO:0042819,GO:0042822,GO:0042823,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046184,GO:0046483,GO:0046872,GO:0046914,GO:0048037,GO:0050570,GO:0050662,GO:0051186,GO:0051188,GO:0051287,GO:0055114,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 1.1.1.262 ko:K00097 ko00750,ko01100,map00750,map01100 M00124 R05681,R05837,R07406 RC00089,RC00675,RC01475 ko00000,ko00001,ko00002,ko01000 - - iECO111_1330.ECO111_0056 PdxA k59_1289667_1 436308.Nmar_0595 1.31e-108 325.0 COG1215@1|root,arCOG01389@2157|Archaea 2157|Archaea M PFAM Glycosyl transferase family 2 - - - ko:K07011,ko:K11936 ko02026,map02026 - - - ko00000,ko00001,ko01000,ko01003,ko02000 4.D.1.1.2,4.D.1.1.3 GT2 - Glyco_tranf_2_3,Glycos_transf_2 k59_497773_1 76869.PputGB1_0513 1.96e-54 188.0 COG0477@1|root,COG2814@2|Bacteria,1MVSH@1224|Proteobacteria,1RN70@1236|Gammaproteobacteria,1YVXJ@136845|Pseudomonas putida group 1236|Gammaproteobacteria EGP major facilitator superfamily yajR GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944 - - - - - - - - - - MFS_1,Sugar_tr k59_668772_1 1122137.AQXF01000005_gene1280 5.99e-99 311.0 COG0729@1|root,COG0729@2|Bacteria,1MUKM@1224|Proteobacteria,2TRWD@28211|Alphaproteobacteria 28211|Alphaproteobacteria M COG0729 Outer membrane protein tamA - - ko:K07278 - - - - ko00000,ko02000 1.B.33.2.4 - - Bac_surface_Ag,POTRA k59_839513_1 1307759.JOMJ01000003_gene1982 8.29e-54 184.0 COG2089@1|root,COG2089@2|Bacteria,1MWG3@1224|Proteobacteria,42ME3@68525|delta/epsilon subdivisions,2WJXH@28221|Deltaproteobacteria,2M9ME@213115|Desulfovibrionales 28221|Deltaproteobacteria M PFAM N-acetylneuraminic acid synthase pseI - 2.5.1.56,2.5.1.97 ko:K01654,ko:K15898 ko00520,ko01100,map00520,map01100 - R01804,R04435,R09841 RC00159 ko00000,ko00001,ko01000 - - - NeuB,SAF k59_334393_1 702113.PP1Y_Mpl6282 4.18e-45 152.0 COG1846@1|root,COG1846@2|Bacteria,1Q6QH@1224|Proteobacteria,2US1C@28211|Alphaproteobacteria,2KAAX@204457|Sphingomonadales 204457|Sphingomonadales K helix_turn_helix multiple antibiotic resistance protein - - - - - - - - - - - - MarR k59_334393_2 1192759.AKIB01000017_gene1783 3.15e-34 120.0 COG4922@1|root,COG4922@2|Bacteria,1RDM5@1224|Proteobacteria,2UG54@28211|Alphaproteobacteria 28211|Alphaproteobacteria S protein conserved in bacteria - - - - - - - - - - - - SnoaL_2 k59_498808_2 987059.RBXJA2T_17651 1.35e-20 93.6 COG0367@1|root,COG0367@2|Bacteria,1Q8JT@1224|Proteobacteria,2WG3X@28216|Betaproteobacteria 28216|Betaproteobacteria E Asparagine synthase - - 6.3.5.4 ko:K01953 ko00250,ko01100,ko01110,map00250,map01100,map01110 - R00578 RC00010 ko00000,ko00001,ko01000,ko01002 - - - Asn_synthase k59_1744405_1 566466.NOR53_1747 2.82e-83 250.0 COG0066@1|root,COG0066@2|Bacteria,1MVXB@1224|Proteobacteria,1RNMK@1236|Gammaproteobacteria,1J573@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate leuD - 4.2.1.33,4.2.1.35 ko:K01704 ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230 M00432,M00535 R03896,R03898,R03968,R04001,R10170 RC00976,RC00977,RC01041,RC01046,RC03072 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase_C k59_108231_1 377629.TERTU_1452 3.04e-136 404.0 COG0441@1|root,COG0441@2|Bacteria,1MUP2@1224|Proteobacteria,1RMYE@1236|Gammaproteobacteria,2PN4R@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria J Threonyl and Alanyl tRNA synthetase second additional domain thrS GO:0003674,GO:0003824,GO:0004812,GO:0004829,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006435,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.3 ko:K01868 ko00970,map00970 M00359,M00360 R03663 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,TGS,tRNA-synt_2b,tRNA_SAD k59_1007267_1 1123270.ATUR01000006_gene136 6.58e-180 519.0 COG0823@1|root,COG0823@2|Bacteria,1NU5T@1224|Proteobacteria 1224|Proteobacteria U Involved in the tonB-independent uptake of proteins - - - - - - - - - - - - - k59_1007268_1 1131266.ARWQ01000028_gene1019 0.000138 43.5 COG1730@1|root,arCOG01341@2157|Archaea,41SSP@651137|Thaumarchaeota 651137|Thaumarchaeota O Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding pfdA - - ko:K04797 - - - - ko00000,ko03110 - - - Prefoldin k59_1007268_2 436308.Nmar_0396 1.52e-94 290.0 COG0552@1|root,arCOG01227@2157|Archaea,41SCC@651137|Thaumarchaeota 651137|Thaumarchaeota U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) ftsY - - ko:K03110 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2,3.A.5.7 - - SRP54,SRP54_N k59_554604_1 391615.ABSJ01000026_gene97 6.32e-83 256.0 COG0616@1|root,COG0616@2|Bacteria,1MUXE@1224|Proteobacteria,1RNN9@1236|Gammaproteobacteria 1236|Gammaproteobacteria OU peptidase sohB GO:0005575,GO:0005623,GO:0005886,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0016020,GO:0019538,GO:0043170,GO:0044238,GO:0044464,GO:0071704,GO:0071944,GO:1901564 - ko:K04774 - - - - ko00000,ko01000,ko01002 - - - Peptidase_S49,Peptidase_S49_N k59_277915_1 557598.LHK_00699 6.04e-95 284.0 COG1028@1|root,COG1028@2|Bacteria,1N907@1224|Proteobacteria,2VJ81@28216|Betaproteobacteria,2KQEX@206351|Neisseriales 206351|Neisseriales IQ KR domain fabG2 - 1.1.1.100 ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 k59_674240_1 1415778.JQMM01000001_gene1897 1.24e-25 97.1 2CDU3@1|root,317F0@2|Bacteria,1QEHX@1224|Proteobacteria,1TB85@1236|Gammaproteobacteria,1J7AE@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Protein of unknown function (DUF2970) - - - - - - - - - - - - DUF2970 k59_1351419_3 395493.BegalDRAFT_0882 7.97e-28 112.0 COG0457@1|root,COG4995@1|root,COG0457@2|Bacteria,COG4995@2|Bacteria,1MWRF@1224|Proteobacteria,1RSJ6@1236|Gammaproteobacteria 1236|Gammaproteobacteria S CHAT domain - - - - - - - - - - - - CHAT k59_1295477_1 316407.85676514 7.46e-75 250.0 COG0457@1|root,COG3118@1|root,COG0457@2|Bacteria,COG3118@2|Bacteria,1MVB8@1224|Proteobacteria,1RPSN@1236|Gammaproteobacteria,3XMYE@561|Escherichia 1236|Gammaproteobacteria O cellulose synthase operon protein C bcsC - - ko:K20543 - - - - ko00000,ko02000 1.B.55.3 - - BCSC_C,TPR_16,TPR_19,TPR_8 k59_1073310_1 983544.Lacal_0738 3.81e-79 236.0 COG0590@1|root,COG0590@2|Bacteria,4NNJ2@976|Bacteroidetes,1I17S@117743|Flavobacteriia 976|Bacteroidetes FJ Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2) tadA - 3.5.4.33 ko:K11991 - - R10223 RC00477 ko00000,ko01000,ko03016 - - - MafB19-deam k59_1126257_1 497964.CfE428DRAFT_1645 7e-63 207.0 COG3344@1|root,COG3344@2|Bacteria,46SUD@74201|Verrucomicrobia 74201|Verrucomicrobia L Group II intron maturase-specific domain protein - - - - - - - - - - - - GIIM,RVT_1 k59_1692144_1 998088.B565_3875 5.81e-56 182.0 COG1045@1|root,COG1045@2|Bacteria,1MVFX@1224|Proteobacteria,1RNCA@1236|Gammaproteobacteria,1Y3KI@135624|Aeromonadales 135624|Aeromonadales E serine acetyltransferase cysE - 2.3.1.30 ko:K00640 ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111 M00021 R00586 RC00004,RC00041 ko00000,ko00001,ko00002,ko01000 - - - Hexapep,SATase_N k59_1692146_1 1121481.AUAS01000009_gene65 1.85e-71 233.0 COG1073@1|root,COG3250@1|root,COG1073@2|Bacteria,COG3250@2|Bacteria,4NG6A@976|Bacteroidetes,47Y4T@768503|Cytophagia 976|Bacteroidetes G beta-galactosidase activity - - - - - - - - - - - - - k59_1240751_1 1122137.AQXF01000001_gene3218 1.32e-247 706.0 COG1199@1|root,COG1199@2|Bacteria,1MVCU@1224|Proteobacteria,2TUKS@28211|Alphaproteobacteria 28211|Alphaproteobacteria KL helicase dinG - 3.6.4.12 ko:K03722 - - - - ko00000,ko01000,ko03400 - - - Helicase_C_2 k59_1126269_1 1182590.BN5_01440 1.53e-34 131.0 COG3949@1|root,COG3949@2|Bacteria,1R8UN@1224|Proteobacteria,1S54J@1236|Gammaproteobacteria,1YGSH@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria S Membrane - - - - - - - - - - - - - k59_224594_2 1205680.CAKO01000040_gene603 4.52e-52 172.0 COG0689@1|root,COG0689@2|Bacteria,1MVFZ@1224|Proteobacteria,2TRMC@28211|Alphaproteobacteria,2JQ9X@204441|Rhodospirillales 204441|Rhodospirillales J Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates rph - 2.7.7.56 ko:K00989 - - - - ko00000,ko01000,ko03016 - - - RNase_PH,RNase_PH_C k59_956384_1 1304883.KI912532_gene1035 1.25e-48 179.0 COG2203@1|root,COG3829@1|root,COG5001@1|root,COG2203@2|Bacteria,COG3829@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,2KUCK@206389|Rhodocyclales 206389|Rhodocyclales T Diguanylate cyclase - - - - - - - - - - - - CBS,CZB,EAL,GAF_2,GGDEF,PAS_4,PAS_9 k59_1636823_1 202952.BBLI01000049_gene2969 4.85e-61 206.0 COG0449@1|root,COG0449@2|Bacteria,1MW4K@1224|Proteobacteria,1RMVN@1236|Gammaproteobacteria,3NKBM@468|Moraxellaceae 1236|Gammaproteobacteria M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source glmS GO:0003674,GO:0003824,GO:0004360,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006002,GO:0006040,GO:0006047,GO:0006048,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009226,GO:0009987,GO:0016740,GO:0016769,GO:0018130,GO:0019438,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0034654,GO:0036211,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046349,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.6.1.16 ko:K00820 ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931 - R00768 RC00010,RC00163,RC02752 ko00000,ko00001,ko01000,ko01002 - - iE2348C_1286.E2348C_4039,iEC042_1314.EC042_4115,iECIAI39_1322.ECIAI39_4333,iECNA114_1301.ECNA114_3878,iECOK1_1307.ECOK1_4178,iECSF_1327.ECSF_3577,iECUMN_1333.ECUMN_4259,iEcSMS35_1347.EcSMS35_4097,iLF82_1304.LF82_0844,iNRG857_1313.NRG857_18570,iSFV_1184.SFV_3755,iSF_1195.SF3809,iSFxv_1172.SFxv_4151,iS_1188.S3959,iUMN146_1321.UM146_18835,iUTI89_1310.UTI89_C4281 GATase_6,SIS k59_956395_1 926569.ANT_25190 2.65e-51 177.0 COG0493@1|root,COG0493@2|Bacteria,2G6SR@200795|Chloroflexi 200795|Chloroflexi C PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase - - 1.18.1.2,1.19.1.1 ko:K00528 - - R10159 - ko00000,ko01000 - - - Pyr_redox_2 k59_1351466_2 1415778.JQMM01000001_gene2032 8.08e-64 215.0 COG1629@1|root,COG4771@2|Bacteria,1MUC1@1224|Proteobacteria,1RNHR@1236|Gammaproteobacteria,1J6YF@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P TonB dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_224606_1 1121923.GPUN_1693 1.27e-141 407.0 COG2070@1|root,COG2070@2|Bacteria,1MWPC@1224|Proteobacteria,1RRA4@1236|Gammaproteobacteria,469BX@72275|Alteromonadaceae 1236|Gammaproteobacteria S COG2070 Dioxygenases related to 2-nitropropane dioxygenase - - 1.13.12.16,1.3.1.9 ko:K00459,ko:K02371 ko00061,ko00910,ko01100,ko01212,map00061,map00910,map01100,map01212 M00083 R00025,R04429,R04724,R04955,R04958,R04961,R04966,R04969,R07765 RC00052,RC00076,RC02541,RC02759 ko00000,ko00001,ko00002,ko01000,ko01004 - - - NMO k59_1240778_1 1121937.AUHJ01000018_gene222 1.12e-10 61.2 COG0122@1|root,COG2169@1|root,COG0122@2|Bacteria,COG2169@2|Bacteria,1QTXM@1224|Proteobacteria,1RNQB@1236|Gammaproteobacteria,464XA@72275|Alteromonadaceae 1236|Gammaproteobacteria K COG2169 Adenosine deaminase ada - 3.2.2.21 ko:K01247,ko:K13529 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03000,ko03400 - - - Ada_Zn_binding,AlkA_N,HTH_18,HhH-GPD k59_1240778_2 1042377.AFPJ01000034_gene2404 3.53e-66 214.0 COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,1RMBQ@1236|Gammaproteobacteria,4641R@72275|Alteromonadaceae 1236|Gammaproteobacteria C belongs to the aldehyde dehydrogenase family - - 1.2.1.16,1.2.1.20,1.2.1.79 ko:K00135 ko00250,ko00310,ko00350,ko00650,ko00760,ko01100,ko01120,map00250,map00310,map00350,map00650,map00760,map01100,map01120 M00027 R00713,R00714,R02401 RC00080 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_167406_1 314287.GB2207_03247 7.28e-113 334.0 COG2871@1|root,COG2871@2|Bacteria,1QTUV@1224|Proteobacteria,1RPG5@1236|Gammaproteobacteria,1J4JK@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway nqrF GO:0000166,GO:0003674,GO:0003824,GO:0003954,GO:0005488,GO:0005575,GO:0006810,GO:0006811,GO:0006812,GO:0006814,GO:0008137,GO:0008150,GO:0008152,GO:0015672,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0030001,GO:0030964,GO:0032991,GO:0036094,GO:0043167,GO:0043168,GO:0044425,GO:0048037,GO:0050136,GO:0050660,GO:0050662,GO:0051179,GO:0051234,GO:0051536,GO:0051537,GO:0051540,GO:0055114,GO:0071949,GO:0097159,GO:0098796,GO:1901265,GO:1901363,GO:1902494 1.6.5.8 ko:K00351 - - - - ko00000,ko01000 - - - FAD_binding_6,Fer2,NAD_binding_1 k59_785827_1 1178825.ALIH01000007_gene1638 1.73e-155 460.0 COG0249@1|root,COG0249@2|Bacteria,4NEGB@976|Bacteroidetes,1HX43@117743|Flavobacteriia 976|Bacteroidetes L that it carries out the mismatch recognition step. This protein has a weak ATPase activity mutS GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - ko:K03555 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V k59_1073359_2 1122137.AQXF01000003_gene2251 2.11e-33 118.0 COG3682@1|root,COG3682@2|Bacteria,1RBWP@1224|Proteobacteria,2U5ER@28211|Alphaproteobacteria 28211|Alphaproteobacteria K transcriptional regulator - - - - - - - - - - - - Penicillinase_R k59_1749058_1 436308.Nmar_0177 3.87e-109 323.0 COG0436@1|root,arCOG01131@2157|Archaea,41S8G@651137|Thaumarchaeota 651137|Thaumarchaeota E DegT/DnrJ/EryC1/StrS aminotransferase family - - - - - - - - - - - - Aminotran_1_2 k59_845549_1 314231.FP2506_13264 3.45e-62 198.0 COG0745@1|root,COG0745@2|Bacteria,1MU3A@1224|Proteobacteria,2TR97@28211|Alphaproteobacteria,2PJ02@255475|Aurantimonadaceae 28211|Alphaproteobacteria K Transcriptional regulatory protein, C terminal mtrA - - - - - - - - - - - Response_reg,Trans_reg_C k59_845549_2 1122137.AQXF01000001_gene3273 2.22e-77 242.0 COG0807@1|root,COG0807@2|Bacteria,1MWZR@1224|Proteobacteria,2TR82@28211|Alphaproteobacteria 28211|Alphaproteobacteria H Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate ribA - 3.5.4.25,4.1.99.12 ko:K01497,ko:K14652 ko00740,ko00790,ko01100,ko01110,ko02024,map00740,map00790,map01100,map01110,map02024 M00125,M00840 R00425,R07281 RC00293,RC01792,RC01815,RC02504 ko00000,ko00001,ko00002,ko01000 - - - GTP_cyclohydro2 k59_224636_2 1041159.AZUW01000001_gene3144 1.42e-18 87.0 COG1070@1|root,COG1070@2|Bacteria,1MUHF@1224|Proteobacteria,2TZ8V@28211|Alphaproteobacteria,4B90Y@82115|Rhizobiaceae 28211|Alphaproteobacteria G Sugar (pentulose and hexulose) kinases rhaK - - - - - - - - - - - FGGY_N k59_1749080_1 1397666.RS24_00231 3.18e-49 172.0 COG0008@1|root,COG0008@2|Bacteria,1MUCR@1224|Proteobacteria,2TRSU@28211|Alphaproteobacteria,4BPCX@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) gltX - 6.1.1.17 ko:K01885 ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120 M00121,M00359,M00360 R05578 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016 - - - tRNA-synt_1c k59_1636849_1 436308.Nmar_1364 4.15e-06 47.8 arCOG11049@1|root,arCOG11049@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_1465126_1 644282.Deba_2834 9.22e-45 157.0 COG3103@1|root,COG3103@2|Bacteria,1MVX1@1224|Proteobacteria,42PXB@68525|delta/epsilon subdivisions,2WJKN@28221|Deltaproteobacteria 28221|Deltaproteobacteria T Sh3 type 3 domain protein - - - - - - - - - - - - DUF1302 k59_1749100_1 436308.Nmar_1412 1.22e-37 129.0 COG1601@1|root,arCOG01640@2157|Archaea,41STZ@651137|Thaumarchaeota 651137|Thaumarchaeota J Translation initiation factor - - - ko:K03238 ko03013,map03013 - - - ko00000,ko00001,ko01009,ko03012 - - - eIF-5_eIF-2B k59_559353_1 926551.KB900715_gene2142 5.21e-113 329.0 COG0692@1|root,COG0692@2|Bacteria,4NE2B@976|Bacteroidetes,1HY4H@117743|Flavobacteriia,1ERHD@1016|Capnocytophaga 976|Bacteroidetes L Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine ung GO:0003674,GO:0003824,GO:0004844,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006285,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097506,GO:0097510,GO:0140097,GO:1901360 3.2.2.27 ko:K03648 ko03410,ko05340,map03410,map05340 - - - ko00000,ko00001,ko01000,ko03400 - - - UDG k59_1749112_1 983917.RGE_38160 7.23e-103 308.0 2C96H@1|root,2Z7Q6@2|Bacteria,1PQG4@1224|Proteobacteria,2W1VI@28216|Betaproteobacteria 28216|Betaproteobacteria S Sulfotransferase domain - - - ko:K13472 ko04626,map04626 - - - ko00000,ko00001 - - - Sulfotransfer_3 k59_448179_1 388051.AUFE01000025_gene4493 6.27e-45 164.0 COG0557@1|root,COG0557@2|Bacteria,1NGSQ@1224|Proteobacteria,2VHMM@28216|Betaproteobacteria,1JZN8@119060|Burkholderiaceae 28216|Betaproteobacteria K ribonuclease II rnb - 3.1.13.1 ko:K01147 - - - - ko00000,ko01000,ko03016 - - - RNB k59_503400_1 316407.85676018 1.37e-150 427.0 COG0329@1|root,COG0329@2|Bacteria,1Q7AX@1224|Proteobacteria,1RRZG@1236|Gammaproteobacteria,3XP47@561|Escherichia 1236|Gammaproteobacteria H Neu5Ac) to form pyruvate and N-acetylmannosamine (ManNAc) via a Schiff base intermediate nanA GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006040,GO:0006054,GO:0006082,GO:0008150,GO:0008152,GO:0008747,GO:0009056,GO:0009987,GO:0016054,GO:0016829,GO:0016830,GO:0016833,GO:0016999,GO:0017001,GO:0017144,GO:0019262,GO:0019752,GO:0042737,GO:0042802,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046348,GO:0046395,GO:0071704,GO:1901135,GO:1901136,GO:1901575 4.1.3.3,4.3.3.7 ko:K01639,ko:K01714 ko00261,ko00300,ko00520,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map00520,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R01811,R10147 RC00159,RC00600,RC03062,RC03063 ko00000,ko00001,ko00002,ko01000 - - iAF1260.b3225,iAPECO1_1312.APECO1_3218,iB21_1397.B21_03036,iBWG_1329.BWG_2926,iE2348C_1286.E2348C_3497,iEC042_1314.EC042_3509,iEC55989_1330.EC55989_3638,iECABU_c1320.ECABU_c36330,iECBD_1354.ECBD_0522,iECB_1328.ECB_03085,iECDH10B_1368.ECDH10B_3402,iECDH1ME8569_1439.ECDH1ME8569_3113,iECD_1391.ECD_03085,iECH74115_1262.ECH74115_4542,iECIAI1_1343.ECIAI1_3367,iECNA114_1301.ECNA114_3298,iECO103_1326.ECO103_3966,iECO26_1355.ECO26_4324,iECOK1_1307.ECOK1_3639,iECP_1309.ECP_3308,iECS88_1305.ECS88_3602,iECSF_1327.ECSF_3050,iECSP_1301.ECSP_4194,iECUMN_1333.ECUMN_3699,iECs_1301.ECs4098,iETEC_1333.ETEC_3486,iEcDH1_1363.EcDH1_0481,iEcE24377_1341.EcE24377A_3707,iEcHS_1320.EcHS_A3413,iEcolC_1368.EcolC_0481,iG2583_1286.G2583_3945,iJO1366.b3225,iJR904.b3225,iSDY_1059.SDY_3400,iSFV_1184.SFV_3250,iSF_1195.SF3261,iSFxv_1172.SFxv_3573,iSSON_1240.SSON_3366,iS_1188.S3478,iSbBS512_1146.SbBS512_E3551,iUMN146_1321.UM146_00280,iUTI89_1310.UTI89_C3655,iY75_1357.Y75_RS16725,iZ_1308.Z4583 DHDPS k59_1184821_1 759362.KVU_0013 7.62e-16 82.4 COG0389@1|root,COG0389@2|Bacteria,1MU5X@1224|Proteobacteria,2TQVR@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Nucleotidyltransferase DNA polymerase involved in DNA repair - - - ko:K14161 - - - - ko00000,ko03400 - - - IMS,IMS_C k59_1749131_1 292415.Tbd_0217 1.13e-72 232.0 COG5002@1|root,COG5002@2|Bacteria,1MWF3@1224|Proteobacteria,2VIBV@28216|Betaproteobacteria,1KSVV@119069|Hydrogenophilales 119069|Hydrogenophilales T His Kinase A (phosphoacceptor) domain - - 2.7.13.3 ko:K07636 ko02020,map02020 M00434 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - DUF3329,HATPase_c,HisKA k59_448201_1 945713.IALB_1079 1.77e-107 325.0 COG1866@1|root,COG1866@2|Bacteria 2|Bacteria H phosphoenolpyruvate carboxykinase (ATP) activity pckA GO:0003674,GO:0003824,GO:0004611,GO:0004612,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006094,GO:0008150,GO:0008152,GO:0009058,GO:0016051,GO:0016829,GO:0016830,GO:0016831,GO:0019318,GO:0019319,GO:0044238,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046364,GO:0071704,GO:1901576 4.1.1.49 ko:K01610 ko00010,ko00020,ko00620,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00710,map01100,map01110,map01120,map01130,map01200 M00003,M00170 R00341 RC00002,RC02741 ko00000,ko00001,ko00002,ko01000 - - - PEPCK_ATP k59_1749141_1 1122137.AQXF01000005_gene1108 6.74e-201 567.0 COG1251@1|root,COG1251@2|Bacteria,1MW58@1224|Proteobacteria,2TW0G@28211|Alphaproteobacteria 28211|Alphaproteobacteria C PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase - - 1.18.1.3 ko:K00529 ko00071,ko00360,ko01120,ko01220,map00071,map00360,map01120,map01220 M00545 R02000,R06782,R06783 RC00098 br01602,ko00000,ko00001,ko00002,ko01000 - - - Fer2_BFD,Pyr_redox_2,Reductase_C,Rieske k59_1749141_2 1304275.C41B8_12990 1.29e-12 66.6 COG2961@1|root,COG2961@2|Bacteria,1MWGA@1224|Proteobacteria,1RNI1@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Specifically methylates the adenine in position 2030 of 23S rRNA rlmJ - 2.1.1.266 ko:K07115 - - - - ko00000,ko01000,ko03009 - - - RsmJ k59_1295587_2 279714.FuraDRAFT_1399 1.07e-40 137.0 COG0102@1|root,COG0102@2|Bacteria,1RA11@1224|Proteobacteria,2VQ07@28216|Betaproteobacteria,2KQX3@206351|Neisseriales 206351|Neisseriales J This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly rplM - - ko:K02871 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L13 k59_956487_2 1089552.KI911559_gene575 4.38e-22 97.4 COG1040@1|root,COG1040@2|Bacteria,1RHAV@1224|Proteobacteria,2TV7G@28211|Alphaproteobacteria,2JSB6@204441|Rhodospirillales 204441|Rhodospirillales S Phosphoribosyl transferase domain - - - - - - - - - - - - Pribosyltran k59_1465196_2 1033736.CAHK01000039_gene139 1.36e-23 100.0 COG5282@1|root,COG5282@2|Bacteria,2GJ8E@201174|Actinobacteria,4F959@85019|Brevibacteriaceae 201174|Actinobacteria S Zincin-like metallopeptidase - - - - - - - - - - - - Zincin_2 k59_1011908_1 767434.Fraau_1087 2.16e-49 169.0 COG0167@1|root,COG0167@2|Bacteria,1MU7C@1224|Proteobacteria,1RMCP@1236|Gammaproteobacteria,1X33F@135614|Xanthomonadales 135614|Xanthomonadales F Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor pyrD - 1.3.5.2 ko:K00254 ko00240,ko01100,map00240,map01100 M00051 R01868 RC00051 ko00000,ko00001,ko00002,ko01000 - - - DHO_dh k59_1240882_1 1137281.D778_02135 9.57e-106 330.0 COG0532@1|root,COG0532@2|Bacteria,4NGP3@976|Bacteroidetes,1HYR7@117743|Flavobacteriia 976|Bacteroidetes J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex infB - - ko:K02519 - - - - ko00000,ko03012,ko03029 - - - GTP_EFTU,GTP_EFTU_D2,IF-2,IF2_N k59_448226_1 1197477.IA57_03270 6.73e-107 334.0 COG0532@1|root,COG0532@2|Bacteria,4NGP3@976|Bacteroidetes,1HYR7@117743|Flavobacteriia 976|Bacteroidetes J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex infB - - ko:K02519 - - - - ko00000,ko03012,ko03029 - - - GTP_EFTU,GTP_EFTU_D2,IF-2,IF2_N k59_1295610_1 517722.AEUE01000008_gene75 3.33e-89 273.0 COG3004@1|root,COG3004@2|Bacteria,1MW15@1224|Proteobacteria,2TSI5@28211|Alphaproteobacteria,2K097@204457|Sphingomonadales 204457|Sphingomonadales P ) H( ) antiporter that extrudes sodium in exchange for external protons - - - ko:K03313 - - - - ko00000,ko02000 2.A.33.1 - - Na_H_antiport_1 k59_956511_1 1415756.JQMY01000001_gene3628 7.16e-131 384.0 COG0600@1|root,COG0600@2|Bacteria,1MU6Q@1224|Proteobacteria,2TQT6@28211|Alphaproteobacteria,2PDUT@252301|Oceanicola 28211|Alphaproteobacteria P Binding-protein-dependent transport system inner membrane component nasE - - ko:K02050,ko:K15577 ko00910,ko02010,map00910,map02010 M00188,M00438 - - ko00000,ko00001,ko00002,ko02000 3.A.1.16,3.A.1.16.1,3.A.1.16.2,3.A.1.17 - - BPD_transp_1 k59_559400_2 1008457.BAEX01000106_gene2150 1.15e-18 88.6 COG0466@1|root,COG0466@2|Bacteria,4NE1G@976|Bacteroidetes,1HX2R@117743|Flavobacteriia,47HQS@76831|Myroides 976|Bacteroidetes O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner lon - 3.4.21.53 ko:K01338 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - AAA,LON_substr_bdg,Lon_C k59_674374_1 1121877.JQKF01000014_gene5 2.73e-35 129.0 COG2345@1|root,COG2345@2|Bacteria,2HGTI@201174|Actinobacteria,4CNV8@84992|Acidimicrobiia 2|Bacteria K helix_turn_helix, Arsenical Resistance Operon Repressor - - - - - - - - - - - - HTH_20 k59_674374_2 1198452.Jab_2c10890 1.49e-12 73.9 COG2010@1|root,COG2132@1|root,COG2010@2|Bacteria,COG2132@2|Bacteria,1MV74@1224|Proteobacteria,2VK95@28216|Betaproteobacteria,474TT@75682|Oxalobacteraceae 28216|Betaproteobacteria C Multicopper oxidase nirK - 1.3.3.5,1.7.2.1 ko:K00368,ko:K08100 ko00860,ko00910,ko01110,ko01120,map00860,map00910,map01110,map01120 M00529 R00783,R00785,R02394 RC00086,RC01983 ko00000,ko00001,ko00002,ko01000 - - - Copper-bind,Cu-oxidase,Cu-oxidase_2,Cu-oxidase_3,Cytochrome_CBB3 k59_448253_1 666685.R2APBS1_3246 1.71e-45 168.0 COG1100@1|root,COG1100@2|Bacteria,1QXSV@1224|Proteobacteria,1S5FA@1236|Gammaproteobacteria,1X4RA@135614|Xanthomonadales 135614|Xanthomonadales S 50S ribosome-binding GTPase - - - ko:K06883 - - - - ko00000 - - - DUF697,MMR_HSR1 k59_785916_1 1307759.JOMJ01000003_gene628 2.56e-47 155.0 COG0105@1|root,COG0105@2|Bacteria,1R9ZA@1224|Proteobacteria,42RIR@68525|delta/epsilon subdivisions,2WP3R@28221|Deltaproteobacteria,2MBKB@213115|Desulfovibrionales 28221|Deltaproteobacteria F Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate ndk GO:0003674,GO:0003824,GO:0004550,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006165,GO:0006220,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009132,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0019205,GO:0019637,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0044464,GO:0046483,GO:0046939,GO:0055086,GO:0071704,GO:0072521,GO:0072527,GO:1901360,GO:1901564 2.7.4.6 ko:K00940 ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016 M00049,M00050,M00052,M00053 R00124,R00139,R00156,R00330,R00570,R00722,R01137,R01857,R02093,R02326,R02331,R03530,R11894,R11895 RC00002 ko00000,ko00001,ko00002,ko01000,ko04131 - - - NDK k59_1692279_1 1415778.JQMM01000001_gene1616 1.04e-71 223.0 COG0777@1|root,COG0777@2|Bacteria,1MW8G@1224|Proteobacteria,1RNDS@1236|Gammaproteobacteria,1J4MN@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria I Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA accD GO:0001676,GO:0003674,GO:0003676,GO:0003677,GO:0003723,GO:0003729,GO:0003824,GO:0003989,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006417,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008270,GO:0008610,GO:0009058,GO:0009317,GO:0009329,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0016053,GO:0016421,GO:0016874,GO:0016885,GO:0017148,GO:0019222,GO:0019752,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032787,GO:0032991,GO:0034248,GO:0034249,GO:0042759,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046872,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0071704,GO:0072330,GO:0080090,GO:0097159,GO:1901363,GO:1901576,GO:1902494,GO:1990234,GO:2000112,GO:2000113 2.1.3.15,6.4.1.2 ko:K01963 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04386 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 - - iPC815.YPO2768,iUTI89_1310.UTI89_C2601 Carboxyl_trans k59_1692279_2 1166948.JPZL01000004_gene382 2.57e-61 198.0 COG0159@1|root,COG0159@2|Bacteria,1MXJV@1224|Proteobacteria,1RMGN@1236|Gammaproteobacteria,1XHKU@135619|Oceanospirillales 135619|Oceanospirillales E The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate trpA - 4.2.1.20 ko:K01695 ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230 M00023 R00674,R02340,R02722 RC00209,RC00210,RC00700,RC00701,RC02868 ko00000,ko00001,ko00002,ko01000 - - - Trp_syntA k59_1011969_1 435908.IDSA_08930 6.27e-78 259.0 COG1061@1|root,COG1974@1|root,COG3886@1|root,COG1061@2|Bacteria,COG1974@2|Bacteria,COG3886@2|Bacteria,1MV9F@1224|Proteobacteria,1RNAN@1236|Gammaproteobacteria,2QGM4@267893|Idiomarinaceae 1236|Gammaproteobacteria L Type III restriction enzyme, res subunit - - - - - - - - - - - - DUF3427,Helicase_C,Methyltransf_25,PLDc_2,ResIII k59_505663_1 436308.Nmar_1713 5.26e-92 272.0 COG1136@1|root,arCOG00922@2157|Archaea,41T2R@651137|Thaumarchaeota 651137|Thaumarchaeota E ABC-type antimicrobial peptide transport system, ATPase component - - - ko:K02003,ko:K09810 ko02010,map02010 M00255,M00258 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1,3.A.1.125 - - ABC_tran k59_505663_2 436308.Nmar_1714 2.08e-209 585.0 COG4591@1|root,arCOG02313@2157|Archaea,41TBB@651137|Thaumarchaeota 651137|Thaumarchaeota M FtsX-like permease family - - - ko:K09808 ko02010,map02010 M00255 - - ko00000,ko00001,ko00002,ko02000 3.A.1.125 - - FtsX,MacB_PCD k59_1467311_1 999541.bgla_2g04360 6.92e-17 80.9 COG1622@1|root,COG1622@2|Bacteria,1MWHZ@1224|Proteobacteria,2VHBH@28216|Betaproteobacteria,1JZWX@119060|Burkholderiaceae 28216|Betaproteobacteria C ubiquinol oxidase subunit cyoA2 - 1.10.3.10 ko:K02297 ko00190,ko01100,map00190,map01100 M00417 R11335 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.4.5 - - COX2,COX_ARM k59_1467311_2 1442599.JAAN01000014_gene3612 1.11e-16 80.1 COG0477@1|root,COG0477@2|Bacteria,1MU46@1224|Proteobacteria,1RMF0@1236|Gammaproteobacteria,1X5I8@135614|Xanthomonadales 135614|Xanthomonadales EGP Sugar (and other) transporter - - - - - - - - - - - - MFS_1,Sugar_tr k59_1803781_1 1121422.AUMW01000024_gene286 1.58e-17 87.4 COG0642@1|root,COG3829@1|root,COG4191@1|root,COG5002@1|root,COG2205@2|Bacteria,COG3829@2|Bacteria,COG4191@2|Bacteria,COG5002@2|Bacteria,1TQMV@1239|Firmicutes,247SE@186801|Clostridia,264H3@186807|Peptococcaceae 186801|Clostridia T Signal transduction histidine kinase - - - - - - - - - - - - Fe_hyd_lg_C,GAF_2,HATPase_c,HisKA,PAS_9,Response_reg,dCache_3,sCache_3_3 k59_1013912_1 1123508.JH636444_gene5596 3.81e-44 159.0 COG2203@1|root,COG2208@1|root,COG2203@2|Bacteria,COG2208@2|Bacteria,2J02Z@203682|Planctomycetes 203682|Planctomycetes T COG2208 Serine phosphatase RsbU regulator of sigma subunit - - - - - - - - - - - - SpoIIE k59_958648_1 1121912.AUHD01000003_gene3153 2.34e-89 274.0 COG0165@1|root,COG0165@2|Bacteria,4NFCY@976|Bacteroidetes,1HX0C@117743|Flavobacteriia 976|Bacteroidetes E argininosuccinate lyase argH GO:0003674,GO:0003824,GO:0004056,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016829,GO:0016840,GO:0016842,GO:0019752,GO:0042450,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.3.2.1 ko:K01755 ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230 M00029,M00844,M00845 R01086 RC00445,RC00447 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Lyase_1 k59_958648_2 616991.JPOO01000001_gene3615 2.65e-18 82.0 COG1940@1|root,COG1940@2|Bacteria,4NFNR@976|Bacteroidetes,1HZGY@117743|Flavobacteriia,23H2K@178469|Arenibacter 976|Bacteroidetes GK ROK family ppgK - 2.7.1.2,2.7.1.63 ko:K00845,ko:K00886 ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200 M00001,M00549 R00299,R01600,R01786,R02187,R02189 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - ROK k59_561613_1 1122137.AQXF01000002_gene418 4.75e-81 248.0 COG1338@1|root,COG1338@2|Bacteria,1MVBU@1224|Proteobacteria,2TT93@28211|Alphaproteobacteria 28211|Alphaproteobacteria N Plays a role in the flagellum-specific transport system fliP - - ko:K02419 ko02040,map02040 - - - ko00000,ko00001,ko02035,ko02044 3.A.6.2 - - FliP k59_450416_1 555793.WSK_2248 3.59e-59 188.0 COG0396@1|root,COG0396@2|Bacteria,1MUGK@1224|Proteobacteria,2TS8T@28211|Alphaproteobacteria,2K0E3@204457|Sphingomonadales 204457|Sphingomonadales O ABC-type transport system involved in Fe-S cluster assembly, ATPase component sufC - - ko:K09013 - - - - ko00000,ko02000 - - - ABC_tran k59_450416_2 1096930.L284_09995 3.17e-97 289.0 COG0719@1|root,COG0719@2|Bacteria,1MVK0@1224|Proteobacteria,2TTK9@28211|Alphaproteobacteria,2K20T@204457|Sphingomonadales 204457|Sphingomonadales O ABC-type transport system involved in Fe-S cluster assembly, permease component sufD - - ko:K09015 - - - - ko00000 - - - UPF0051 k59_1751199_1 795666.MW7_0584 3.13e-62 199.0 COG1028@1|root,COG1028@2|Bacteria,1R3ZC@1224|Proteobacteria,2VMWV@28216|Betaproteobacteria,1K5NS@119060|Burkholderiaceae 28216|Betaproteobacteria IQ Enoyl-(Acyl carrier protein) reductase - - - - - - - - - - - - adh_short_C2 k59_505692_1 215803.DB30_4233 3.4e-89 285.0 COG1009@1|root,COG1009@2|Bacteria,1MW2M@1224|Proteobacteria,42KZE@68525|delta/epsilon subdivisions,2WIPT@28221|Deltaproteobacteria,2YTZ4@29|Myxococcales 28221|Deltaproteobacteria CP NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus - - - - - - - - - - - - Proton_antipo_M,Proton_antipo_N k59_1128593_1 153948.NAL212_0803 1.29e-09 62.0 COG1276@1|root,COG2010@1|root,COG1276@2|Bacteria,COG2010@2|Bacteria,1RG2C@1224|Proteobacteria,2WEJ9@28216|Betaproteobacteria,372HR@32003|Nitrosomonadales 28216|Betaproteobacteria C PFAM Copper resistance D - - - ko:K07245 - - - - ko00000,ko02000 9.B.62.1 - - AhpC-TSA,CopD,Cytochrome_CBB3 k59_450444_1 1227276.HMPREF9148_00329 0.00053 47.8 COG2843@1|root,COG2843@2|Bacteria,4NI9W@976|Bacteroidetes,2G384@200643|Bacteroidia 976|Bacteroidetes M Bacterial capsule synthesis protein - - - ko:K07282 - - - - ko00000 - - - PGA_cap k59_1128602_1 756499.Desde_1687 5.51e-35 133.0 COG0491@1|root,COG0491@2|Bacteria,1TX4N@1239|Firmicutes,24A0N@186801|Clostridia,263MN@186807|Peptococcaceae 186801|Clostridia S Metallo-beta-lactamase superfamily - - - - - - - - - - - - Lactamase_B k59_1751223_1 436308.Nmar_0489 2.48e-41 142.0 COG0580@1|root,arCOG04431@2157|Archaea,41SJI@651137|Thaumarchaeota 651137|Thaumarchaeota G Major Intrinsic Protein - - - ko:K06188 - - - - ko00000,ko02000 1.A.8 - - MIP k59_1078800_1 697282.Mettu_3480 4.35e-74 250.0 COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1145@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1145@2|Bacteria,1MVM0@1224|Proteobacteria,1RNNX@1236|Gammaproteobacteria,1XE3B@135618|Methylococcales 135618|Methylococcales C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin - - 1.2.7.1 ko:K03737 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00173,M00307 R01196,R10866 RC00004,RC02742 br01601,ko00000,ko00001,ko00002,ko01000 - - - EKR,Fer4_16,PFOR_II,POR,POR_N,TPP_enzyme_C k59_740299_1 935840.JAEQ01000025_gene4199 9.3e-60 199.0 COG2271@1|root,COG2271@2|Bacteria,1MVV4@1224|Proteobacteria,2TS66@28211|Alphaproteobacteria,43K0R@69277|Phyllobacteriaceae 28211|Alphaproteobacteria G Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 k59_1078804_1 1005048.CFU_3754 0.000397 42.7 COG0077@1|root,COG1605@1|root,COG0077@2|Bacteria,COG1605@2|Bacteria,1MU60@1224|Proteobacteria,2VJEV@28216|Betaproteobacteria,472K2@75682|Oxalobacteraceae 28216|Betaproteobacteria E TIGRFAM chorismate mutase domain of proteobacterial P-protein, clade 2 pheA - 4.2.1.51,4.2.1.91,5.4.99.5 ko:K01713,ko:K14170 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00024,M00025 R00691,R01373,R01715 RC00360,RC03116 ko00000,ko00001,ko00002,ko01000 - - - ACT,CM_2,PDT k59_1078804_2 1485544.JQKP01000014_gene1896 5.71e-48 165.0 COG0111@1|root,COG0111@2|Bacteria,1MU5Z@1224|Proteobacteria,2VIHG@28216|Betaproteobacteria,44V68@713636|Nitrosomonadales 28216|Betaproteobacteria C D-isomer specific 2-hydroxyacid dehydrogenase catalytic region serA - 1.1.1.399,1.1.1.95 ko:K00058 ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230 M00020 R01513 RC00031 ko00000,ko00001,ko00002,ko01000,ko04147 - - - 2-Hacid_dh,2-Hacid_dh_C k59_1192081_3 323098.Nwi_2120 1.57e-24 100.0 COG2801@1|root,COG2801@2|Bacteria,1MVXQ@1224|Proteobacteria,2TU72@28211|Alphaproteobacteria,3JYE2@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria L COG2801 Transposase and inactivated derivatives - - - - - - - - - - - - HTH_21,rve,rve_3 k59_118755_1 1077972.ARGLB_083_01420 5.77e-11 65.1 COG2071@1|root,COG2071@2|Bacteria,2HRHB@201174|Actinobacteria,1WBJX@1268|Micrococcaceae 201174|Actinobacteria S Peptidase C26 - - - ko:K07010 - - - - ko00000,ko01002 - - - Peptidase_C26 k59_118755_2 1117647.M5M_08460 4.43e-34 127.0 28IBE@1|root,2Z8DX@2|Bacteria,1NC7D@1224|Proteobacteria,1RP6N@1236|Gammaproteobacteria,1J5CJ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Putative amidoligase enzyme - - - - - - - - - - - - Amidoligase_2 k59_1756778_1 748247.AZKH_4372 1.93e-33 132.0 COG3637@1|root,COG3637@2|Bacteria,1R42W@1224|Proteobacteria,2WHYH@28216|Betaproteobacteria 28216|Betaproteobacteria M Putative outer membrane beta-barrel porin, MtrB/PioB - - - - - - - - - - - - MtrB_PioB k59_1192091_1 1280953.HOC_09804 3.52e-35 133.0 COG1960@1|root,COG1960@2|Bacteria,1MVJC@1224|Proteobacteria,2TUVB@28211|Alphaproteobacteria,43WWF@69657|Hyphomonadaceae 28211|Alphaproteobacteria I acyl-CoA dehydrogenase - - 1.3.8.7 ko:K00249 ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320 M00013,M00036,M00087 R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754 RC00052,RC00068,RC00076,RC00095,RC00148,RC00246 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_5692_1 1122197.ATWI01000009_gene2127 3.08e-31 120.0 COG4067@1|root,COG4067@2|Bacteria,1N0VV@1224|Proteobacteria,1SZUE@1236|Gammaproteobacteria,467V0@72275|Alteromonadaceae 1236|Gammaproteobacteria O protein conserved in archaea - - - - - - - - - - - - Zn_protease k59_5692_2 1415778.JQMM01000001_gene1079 1.26e-22 98.6 COG1305@1|root,COG1305@2|Bacteria,1MVV3@1224|Proteobacteria,1RRIA@1236|Gammaproteobacteria,1J593@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E K COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit IV02_00930 - - - - - - - - - - - 7TM_transglut,Transglut_i_TM k59_740309_1 1122137.AQXF01000001_gene2753 6.14e-157 454.0 COG0155@1|root,COG0155@2|Bacteria,1MVVB@1224|Proteobacteria,2TRCR@28211|Alphaproteobacteria 28211|Alphaproteobacteria C Sulfite reductase cysI - 1.8.1.2 ko:K00381 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00176 R00858 RC00065 ko00000,ko00001,ko00002,ko01000 - - - NIR_SIR,NIR_SIR_ferr k59_740309_2 1122137.AQXF01000001_gene2754 2.1e-65 204.0 COG3749@1|root,COG3749@2|Bacteria,1RJR9@1224|Proteobacteria,2UBPF@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Bacterial protein of unknown function (DUF934) - - - - - - - - - - - - DUF934 k59_740309_3 1122137.AQXF01000001_gene2755 4.77e-21 89.0 COG0175@1|root,COG0175@2|Bacteria,1MXUR@1224|Proteobacteria,2U5AP@28211|Alphaproteobacteria 28211|Alphaproteobacteria EH Reduction of activated sulfate into sulfite cysH - 1.8.4.10,1.8.4.8 ko:K00390 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00176 R02021 RC00007,RC02862 ko00000,ko00001,ko00002,ko01000 - - - PAPS_reduct k59_118775_1 1122135.KB893166_gene2857 5.25e-158 456.0 COG3278@1|root,COG3278@2|Bacteria,1MU18@1224|Proteobacteria,2TR2C@28211|Alphaproteobacteria 28211|Alphaproteobacteria C Belongs to the heme-copper respiratory oxidase family ccoN GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015672,GO:0015980,GO:0015988,GO:0015990,GO:0016020,GO:0022900,GO:0022904,GO:0034220,GO:0044237,GO:0044464,GO:0045333,GO:0051179,GO:0051234,GO:0055085,GO:0055114,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:1902600 1.9.3.1 ko:K00404 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00156 - - ko00000,ko00001,ko00002,ko01000 3.D.4.3 - - COX1 k59_1587184_1 1907.SGLAU_27635 4.78e-66 213.0 COG1526@1|root,COG1526@2|Bacteria,2GKWC@201174|Actinobacteria 201174|Actinobacteria C Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH fdhD - - ko:K02379 - - - - ko00000 - - - FdhD-NarQ k59_513812_1 398767.Glov_2538 1.96e-77 255.0 COG0525@1|root,COG0525@2|Bacteria,1MV7B@1224|Proteobacteria,42MPZ@68525|delta/epsilon subdivisions,2WIR9@28221|Deltaproteobacteria 28221|Deltaproteobacteria J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner valS GO:0003674,GO:0003824,GO:0004812,GO:0004832,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006438,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.9 ko:K01873 ko00970,map00970 M00359,M00360 R03665 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1 k59_175216_1 194867.ALBQ01000057_gene3427 3.38e-112 345.0 COG4993@1|root,COG4993@2|Bacteria,1MUQX@1224|Proteobacteria,2TQMV@28211|Alphaproteobacteria,2K0W1@204457|Sphingomonadales 204457|Sphingomonadales G Glucose dehydrogenase - - 1.1.5.2 ko:K00117 ko00030,ko01100,ko01110,ko01130,map00030,map01100,map01110,map01130 - R06620 RC00066 ko00000,ko00001,ko01000 - - - PQQ,PQQ_2 k59_457607_1 1123399.AQVE01000012_gene2958 2.33e-92 280.0 COG0685@1|root,COG0685@2|Bacteria,1MXTZ@1224|Proteobacteria,1S185@1236|Gammaproteobacteria 1236|Gammaproteobacteria E COG0685 5,10-methylenetetrahydrofolate reductase - - 1.5.1.20 ko:K00297 ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,map00670,map00720,map01100,map01120,map01200,map01523 M00377 R01224,R07168 RC00081 ko00000,ko00001,ko00002,ko01000 - - - MTHFR k59_965887_1 436308.Nmar_0295 1.1e-239 671.0 COG1245@1|root,arCOG00187@2157|Archaea,41S8K@651137|Thaumarchaeota 651137|Thaumarchaeota E RNase L inhibitor, RLI - - - ko:K06174 - - - - ko00000,ko03009 - - - ABC_tran,Fer4,RLI k59_1417737_1 1415778.JQMM01000001_gene1472 1.83e-112 337.0 COG0348@1|root,COG0348@2|Bacteria,1MVFY@1224|Proteobacteria,1RMDI@1236|Gammaproteobacteria,1J4E8@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C COG0348 Polyferredoxin ccoG - - - - - - - - - - - Fer4_18,Fer4_5,FixG_C k59_1417738_1 1122137.AQXF01000005_gene1196 2.35e-82 249.0 28JIP@1|root,2Z82C@2|Bacteria,1R5N9@1224|Proteobacteria,2U95E@28211|Alphaproteobacteria 28211|Alphaproteobacteria S S1/P1 Nuclease - - - - - - - - - - - - S1-P1_nuclease k59_118797_1 266117.Rxyl_0618 4.21e-77 255.0 COG1048@1|root,COG1048@2|Bacteria,2GJD5@201174|Actinobacteria,4CPJQ@84995|Rubrobacteria 84995|Rubrobacteria C Aconitase C-terminal domain - - 4.2.1.3 ko:K01681 ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00173,M00740 R01324,R01325,R01900 RC00497,RC00498,RC00618 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase,Aconitase_C k59_1022959_1 1144305.PMI02_00672 3.59e-62 200.0 COG3386@1|root,COG3386@2|Bacteria 2|Bacteria G gluconolactonase activity - - 3.1.1.17 ko:K01053 ko00030,ko00053,ko00930,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,map00030,map00053,map00930,map01100,map01110,map01120,map01130,map01200,map01220 M00129 R01519,R02933,R03751 RC00537,RC00983 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Esterase,SGL k59_853217_1 521719.ATXQ01000011_gene154 3.35e-47 159.0 COG1392@1|root,COG1392@2|Bacteria,1MXY9@1224|Proteobacteria,1RQHT@1236|Gammaproteobacteria,1YDJU@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria P Protein of unknown function DUF47 UF78_21250 - - ko:K07220 - - - - ko00000 - - - PhoU_div k59_175229_1 1485544.JQKP01000002_gene1422 9.11e-104 315.0 COG0654@1|root,COG0654@2|Bacteria,1MU6I@1224|Proteobacteria,2VIPS@28216|Betaproteobacteria,44V5S@713636|Nitrosomonadales 28216|Betaproteobacteria CH TIGRFAM Ubiquinone biosynthesis hydroxylase, UbiH UbiF VisC COQ6 family ubiF - - ko:K03185 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00117 R04989,R08773 RC02670 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,FAD_binding_3,SE k59_62462_1 1229909.NSED_03150 7.05e-43 147.0 COG0024@1|root,arCOG01001@2157|Archaea,41SEA@651137|Thaumarchaeota 651137|Thaumarchaeota E Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val) map - 3.4.11.18 ko:K01265 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M24 k59_1078853_1 177437.HRM2_15130 1.66e-14 77.4 COG5557@1|root,COG5557@2|Bacteria,1QURB@1224|Proteobacteria,43BT1@68525|delta/epsilon subdivisions,2X73S@28221|Deltaproteobacteria,2MMX3@213118|Desulfobacterales 28221|Deltaproteobacteria C Pfam Polysulphide reductase, NrfD actF - - - - - - - - - - - - k59_1192135_2 883.DvMF_3055 9.59e-39 137.0 COG0225@1|root,COG0225@2|Bacteria,1R33Z@1224|Proteobacteria,42RS2@68525|delta/epsilon subdivisions,2X9GK@28221|Deltaproteobacteria,2MHJN@213115|Desulfovibrionales 28221|Deltaproteobacteria O Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine msrA - 1.8.4.11 ko:K07304 - - - - ko00000,ko01000 - - - PMSR k59_853242_1 580332.Slit_2417 6.61e-46 165.0 COG4783@1|root,COG4783@2|Bacteria,1MVFV@1224|Proteobacteria,2VHAY@28216|Betaproteobacteria,44VK3@713636|Nitrosomonadales 28216|Betaproteobacteria S Peptidase family M48 yggG_1 - - - - - - - - - - - Peptidase_M48,TPR_19 k59_62476_1 1382304.JNIL01000001_gene1395 5.39e-09 58.2 COG1024@1|root,COG1024@2|Bacteria,1VUG6@1239|Firmicutes,4HVRB@91061|Bacilli 91061|Bacilli I Enoyl-CoA hydratase/isomerase - - - - - - - - - - - - ECH_1 k59_796761_1 656519.Halsa_1107 2.35e-13 75.5 COG0304@1|root,COG0304@2|Bacteria,1TPA7@1239|Firmicutes,247VF@186801|Clostridia,3WAA8@53433|Halanaerobiales 186801|Clostridia I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP fabF - 2.3.1.179 ko:K09458 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119 RC00039,RC02728,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Ketoacyl-synt_C,ketoacyl-synt k59_1192139_1 366602.Caul_5439 3.54e-35 132.0 COG3239@1|root,COG3239@2|Bacteria,1MW29@1224|Proteobacteria,2TSHW@28211|Alphaproteobacteria 28211|Alphaproteobacteria I Alkane 1-monooxygenase - - 1.14.15.3 ko:K00496 ko00071,ko00930,map00071,map00930 - R01347,R02281,R06945 RC00478 ko00000,ko00001,ko01000 - - - FA_desaturase k59_627054_1 666686.B1NLA3E_20540 1.01e-45 166.0 COG0491@1|root,COG0607@1|root,COG0491@2|Bacteria,COG0607@2|Bacteria,1TPE2@1239|Firmicutes,4H9WH@91061|Bacilli,1ZCD8@1386|Bacillus 91061|Bacilli P Rhodanese Homology Domain - - - - - - - - - - - - Lactamase_B,Rhodanese k59_740352_1 985054.JQEZ01000003_gene1514 6.58e-71 229.0 COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2TQR1@28211|Alphaproteobacteria,4NARZ@97050|Ruegeria 28211|Alphaproteobacteria C Belongs to the aldehyde dehydrogenase family gabD - 1.2.1.16,1.2.1.20,1.2.1.79 ko:K00135 ko00250,ko00310,ko00350,ko00650,ko00760,ko01100,ko01120,map00250,map00310,map00350,map00650,map00760,map01100,map01120 M00027 R00713,R00714,R02401 RC00080 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_1361567_1 498211.CJA_0440 2.94e-138 411.0 COG1185@1|root,COG1185@2|Bacteria,1MVB9@1224|Proteobacteria,1RNBF@1236|Gammaproteobacteria,1FGWI@10|Cellvibrio 1236|Gammaproteobacteria J Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction pnp GO:0000166,GO:0000175,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004518,GO:0004527,GO:0004532,GO:0004540,GO:0004654,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0008408,GO:0009056,GO:0009057,GO:0009266,GO:0009408,GO:0009628,GO:0009892,GO:0009987,GO:0010468,GO:0010605,GO:0010629,GO:0016070,GO:0016071,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016796,GO:0016896,GO:0017076,GO:0019001,GO:0019222,GO:0019439,GO:0030551,GO:0032553,GO:0032555,GO:0032561,GO:0034641,GO:0034655,GO:0035438,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0050896,GO:0060255,GO:0065007,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0097159,GO:0097367,GO:0140098,GO:1901265,GO:1901360,GO:1901361,GO:1901363,GO:1901575 2.7.7.8 ko:K00962 ko00230,ko00240,ko03018,map00230,map00240,map03018 M00394 R00437,R00438,R00439,R00440 RC02795 ko00000,ko00001,ko00002,ko01000,ko03016,ko03019 - - - KH_1,PNPase,RNase_PH,RNase_PH_C,S1 k59_909402_1 1197477.IA57_06490 3.01e-96 288.0 28IZ7@1|root,2Z8WQ@2|Bacteria,4NIAK@976|Bacteroidetes,1I09F@117743|Flavobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_288461_2 436308.Nmar_1789 3.24e-70 217.0 COG1711@1|root,arCOG00551@2157|Archaea,41SVQ@651137|Thaumarchaeota 651137|Thaumarchaeota L protein conserved in archaea - - - ko:K09723 - - - - ko00000,ko03032 - - - - k59_853267_1 290397.Adeh_2899 4.53e-36 140.0 COG0823@1|root,COG0823@2|Bacteria,1NKG5@1224|Proteobacteria 1224|Proteobacteria U Involved in the tonB-independent uptake of proteins - - - - - - - - - - - - PD40 k59_1192155_1 983545.Glaag_0438 2.08e-14 72.0 COG0194@1|root,COG0194@2|Bacteria,1MW92@1224|Proteobacteria,1RN09@1236|Gammaproteobacteria,466I4@72275|Alteromonadaceae 1236|Gammaproteobacteria F Essential for recycling GMP and indirectly, cGMP gmk GO:0003674,GO:0003824,GO:0004385,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009126,GO:0009132,GO:0009135,GO:0009150,GO:0009161,GO:0009165,GO:0009167,GO:0009179,GO:0009185,GO:0009259,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0042278,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046037,GO:0046128,GO:0046483,GO:0046710,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901576,GO:1901657 2.7.4.8 ko:K00942 ko00230,ko01100,map00230,map01100 M00050 R00332,R02090 RC00002 ko00000,ko00001,ko00002,ko01000 - - iAPECO1_1312.APECO1_2813,iPC815.YPO0040,iSBO_1134.SBO_3729,iSFV_1184.SFV_3881,iSFxv_1172.SFxv_4016,iUTI89_1310.UTI89_C4193 Guanylate_kin k59_1192155_2 1335757.SPICUR_01535 1.94e-27 103.0 COG1758@1|root,COG1758@2|Bacteria,1N6TX@1224|Proteobacteria,1SCSR@1236|Gammaproteobacteria,1WYPW@135613|Chromatiales 135613|Chromatiales K Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits rpoZ - 2.7.7.6 ko:K03060 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb6 k59_62500_1 158500.BV97_05761 3.54e-57 185.0 COG1309@1|root,COG1309@2|Bacteria,1RKKY@1224|Proteobacteria,2UBFF@28211|Alphaproteobacteria,2K6NG@204457|Sphingomonadales 204457|Sphingomonadales K Bacterial regulatory proteins, tetR family - - - - - - - - - - - - TetR_N k59_118858_1 158500.BV97_02803 1.42e-73 235.0 2DXBE@1|root,3448G@2|Bacteria,1RC34@1224|Proteobacteria,2U6HS@28211|Alphaproteobacteria,2K43Q@204457|Sphingomonadales 204457|Sphingomonadales K Bacterial regulatory proteins, tetR family - - - - - - - - - - - - TetR_N k59_231515_1 477228.YO5_06521 4.86e-17 85.5 COG2207@1|root,COG2207@2|Bacteria,1MX23@1224|Proteobacteria,1RRXM@1236|Gammaproteobacteria,1Z1AX@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria K COG2207 AraC-type DNA-binding domain-containing proteins oruR - - - - - - - - - - - Arabinose_bd,HTH_18 k59_231515_2 338969.Rfer_2680 4.18e-09 56.2 COG5652@1|root,COG5652@2|Bacteria,1N9QA@1224|Proteobacteria,2VW74@28216|Betaproteobacteria,4AFP6@80864|Comamonadaceae 28216|Betaproteobacteria S VanZ like family - - - - - - - - - - - - VanZ k59_965950_1 1479237.JMLY01000001_gene1359 2.19e-10 62.0 COG1589@1|root,COG1589@2|Bacteria,1N0T7@1224|Proteobacteria,1S9FJ@1236|Gammaproteobacteria,464U9@72275|Alteromonadaceae 1236|Gammaproteobacteria D Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly ftsQ GO:0000003,GO:0000278,GO:0000281,GO:0000910,GO:0000917,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0007049,GO:0008150,GO:0009987,GO:0016020,GO:0016021,GO:0016043,GO:0019954,GO:0022402,GO:0022414,GO:0022607,GO:0031224,GO:0031226,GO:0032153,GO:0032505,GO:0032506,GO:0042802,GO:0043093,GO:0044085,GO:0044425,GO:0044459,GO:0044464,GO:0051301,GO:0061640,GO:0071840,GO:0071944,GO:0090529,GO:1902410,GO:1903047 - ko:K03589 ko04112,map04112 - - - ko00000,ko00001,ko03036 - - - FtsQ,POTRA_1 k59_965950_2 1415778.JQMM01000001_gene871 1.23e-59 195.0 COG0849@1|root,COG0849@2|Bacteria,1MUSR@1224|Proteobacteria,1RMXY@1236|Gammaproteobacteria,1J4FB@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria D Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring ftsA GO:0000166,GO:0003674,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008144,GO:0008150,GO:0009898,GO:0009987,GO:0016020,GO:0017076,GO:0030554,GO:0032153,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0051301,GO:0071944,GO:0097159,GO:0097367,GO:0098552,GO:0098562,GO:1901265,GO:1901363 - ko:K03590 ko04112,map04112 - - - ko00000,ko00001,ko03036,ko04812 - - - FtsA,SHS2_FTSA k59_1024089_1 1117647.M5M_16005 6.18e-141 416.0 COG0427@1|root,COG1670@1|root,COG0427@2|Bacteria,COG1670@2|Bacteria,1MUGE@1224|Proteobacteria,1T9YT@1236|Gammaproteobacteria,1J51C@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C COG0427 Acetyl-CoA hydrolase - - - - - - - - - - - - AcetylCoA_hyd_C,AcetylCoA_hydro k59_6873_1 1545915.JROG01000004_gene2162 2.79e-60 203.0 COG0318@1|root,COG0318@2|Bacteria,1NTR7@1224|Proteobacteria,2UPRR@28211|Alphaproteobacteria,2K3JS@204457|Sphingomonadales 204457|Sphingomonadales IQ AMP-binding enzyme - - - ko:K00666 - - - - ko00000,ko01000,ko01004 - - - AMP-binding,AMP-binding_C k59_797897_1 1196083.SALWKB12_0493 9.1e-61 204.0 COG0508@1|root,COG0508@2|Bacteria,1MU7K@1224|Proteobacteria,2VIHA@28216|Betaproteobacteria,2KQE4@206351|Neisseriales 206351|Neisseriales C The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) aceF - 2.3.1.12 ko:K00627 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200 M00307 R00209,R02569 RC00004,RC02742,RC02857 br01601,ko00000,ko00001,ko00002,ko01000 - - - 2-oxoacid_dh,Biotin_lipoyl,E3_binding k59_684289_1 261292.Nit79A3_3425 2.41e-125 372.0 COG5433@1|root,COG5433@2|Bacteria,1MXB5@1224|Proteobacteria,2VMZ8@28216|Betaproteobacteria 28216|Betaproteobacteria L PFAM transposase, IS4 family protein - - - - - - - - - - - - DDE_Tnp_1,DDE_Tnp_1_assoc k59_175972_1 398767.Glov_3556 1.51e-67 233.0 COG4206@1|root,COG4206@2|Bacteria,1MW63@1224|Proteobacteria,43BRF@68525|delta/epsilon subdivisions,2WKAH@28221|Deltaproteobacteria,43TV7@69541|Desulfuromonadales 28221|Deltaproteobacteria P TonB dependent receptor btuB - - ko:K02014,ko:K16092 - - - - ko00000,ko02000 1.B.14,1.B.14.3 - - Plug,TonB_dep_Rec k59_458458_1 1117314.PCIT_17535 8.86e-65 208.0 COG2227@1|root,COG2227@2|Bacteria,1PGF0@1224|Proteobacteria,1SFPC@1236|Gammaproteobacteria 1236|Gammaproteobacteria H Methyltransferase domain - - - - - - - - - - - - Methyltransf_23 k59_175974_1 115417.EPrPW00000013195 1.91e-73 246.0 COG0265@1|root,KOG1421@2759|Eukaryota,1MAFU@121069|Pythiales 121069|Pythiales O Pro-apoptotic serine protease - - - - - - - - - - - - PDZ_1,PDZ_2,Trypsin_2 k59_741138_1 314278.NB231_17158 2.9e-13 72.0 COG0577@1|root,COG0577@2|Bacteria,1MX7X@1224|Proteobacteria,1RRH7@1236|Gammaproteobacteria,1WX4G@135613|Chromatiales 135613|Chromatiales V FtsX-like permease family - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_741138_2 1123073.KB899241_gene3295 3.4e-16 80.1 COG0577@1|root,COG0577@2|Bacteria,1MWBK@1224|Proteobacteria,1RPZF@1236|Gammaproteobacteria,1X3MX@135614|Xanthomonadales 135614|Xanthomonadales V ABC-type antimicrobial peptide transport system, permease component - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_1757779_1 1229909.NSED_04535 1.89e-67 213.0 COG0502@1|root,arCOG00658@2157|Archaea,41S9Y@651137|Thaumarchaeota 651137|Thaumarchaeota H Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism bioB - 2.8.1.6 ko:K01012 ko00780,ko01100,map00780,map01100 M00123,M00573,M00577 R01078 RC00441 ko00000,ko00001,ko00002,ko01000 - - - BATS,Radical_SAM k59_1757779_2 273116.14324615 7.46e-08 56.2 COG0156@1|root,arCOG00113@2157|Archaea,2XUFG@28890|Euryarchaeota 28890|Euryarchaeota E Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide bioF - 2.3.1.29,2.3.1.47 ko:K00639,ko:K00652 ko00260,ko00780,ko01100,map00260,map00780,map01100 M00123,M00573,M00577 R00371,R03210,R10124 RC00004,RC00039,RC00394,RC02725 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 k59_1249392_1 1132855.KB913035_gene245 1.98e-23 104.0 COG1198@1|root,COG1198@2|Bacteria,1MUUZ@1224|Proteobacteria,2VINT@28216|Betaproteobacteria,2KKNP@206350|Nitrosomonadales 206350|Nitrosomonadales L Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA priA - - ko:K04066 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,Helicase_C k59_1024135_1 1117315.AHCA01000002_gene3182 2.72e-15 77.0 COG1595@1|root,COG1595@2|Bacteria,1QZZ2@1224|Proteobacteria,1RSR6@1236|Gammaproteobacteria,2Q10V@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria K Sigma-70, region 4 - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 k59_1193003_1 765420.OSCT_0544 1.57e-12 74.3 COG0420@1|root,COG0420@2|Bacteria,2G60M@200795|Chloroflexi,3757S@32061|Chloroflexia 32061|Chloroflexia L SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'- 5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity sbcD - - ko:K03547 - - - - ko00000,ko03400 - - - Metallophos k59_514582_1 570967.JMLV01000021_gene2400 3.11e-72 219.0 COG1734@1|root,COG1734@2|Bacteria,1RD08@1224|Proteobacteria,2U74V@28211|Alphaproteobacteria,2JSCW@204441|Rhodospirillales 204441|Rhodospirillales T Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters dksA - - ko:K06204 ko02026,map02026 - - - ko00000,ko00001,ko03000,ko03009,ko03021 - - - zf-dskA_traR k59_514582_2 1122135.KB893169_gene2603 6.07e-05 43.5 2E5SK@1|root,330GZ@2|Bacteria 2|Bacteria N flagellar assembly fliX GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - - - - - - - - - - FliX k59_571199_1 1121035.AUCH01000002_gene1673 1.09e-72 233.0 COG0484@1|root,COG0484@2|Bacteria,1MVMS@1224|Proteobacteria,2VHEH@28216|Betaproteobacteria,2KUWF@206389|Rhodocyclales 206389|Rhodocyclales O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins dnaJ - - ko:K03686 - - - - ko00000,ko03029,ko03110 - - - DnaJ,DnaJ_C,DnaJ_CXXCXGXG k59_289609_1 243233.MCA1789 8.13e-101 314.0 COG0542@1|root,COG0542@2|Bacteria,1MV8B@1224|Proteobacteria,1RMH3@1236|Gammaproteobacteria,1XEC1@135618|Methylococcales 135618|Methylococcales O ATP-dependent Clp protease, ATP-binding subunit ClpA clpA - - ko:K03694 - - - - ko00000,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N k59_741151_1 1449353.JQMQ01000005_gene3107 5.78e-48 164.0 COG0789@1|root,COG0789@2|Bacteria,2H5GI@201174|Actinobacteria,2NHMU@228398|Streptacidiphilus 201174|Actinobacteria K TipAS antibiotic-recognition domain tipA - - ko:K21744 - - - - ko00000,ko03000 - - - MerR,MerR-DNA-bind,MerR_1,Methyltransf_11,TipAS k59_1079708_1 1158292.JPOE01000002_gene2815 1.15e-155 448.0 COG0174@1|root,COG0174@2|Bacteria,1MUGQ@1224|Proteobacteria,2VHYE@28216|Betaproteobacteria,1KJNG@119065|unclassified Burkholderiales 28216|Betaproteobacteria H glutamine synthetase glnA GO:0003674,GO:0003824,GO:0006725,GO:0008150,GO:0008152,GO:0009987,GO:0016853,GO:0016866,GO:0034022,GO:0042537,GO:0044237,GO:0050486,GO:0071704,GO:1901360 5.4.4.3,6.3.1.2 ko:K01915,ko:K20712 ko00220,ko00250,ko00627,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00627,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 - R00253,R06988,R09284 RC00010,RC01754,RC02798 ko00000,ko00001,ko01000,ko04147 - - - Gln-synt_C,Gln-synt_N k59_458477_2 936136.ARRT01000006_gene5310 8.33e-35 130.0 COG0468@1|root,COG0468@2|Bacteria,1PK58@1224|Proteobacteria,2UB77@28211|Alphaproteobacteria,4BIMA@82115|Rhizobiaceae 28211|Alphaproteobacteria L AAA domain - - - - - - - - - - - - AAA_24 k59_1475810_1 1229909.NSED_01105 1.98e-103 301.0 COG1146@1|root,arCOG04548@2157|Archaea,41SI0@651137|Thaumarchaeota 651137|Thaumarchaeota C PFAM 4Fe-4S dicluster domain - - - - - - - - - - - - Fer4 k59_741158_1 1121921.KB898707_gene878 4.19e-59 195.0 COG0729@1|root,COG0729@2|Bacteria,1PFDU@1224|Proteobacteria,1RMUN@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Outer membrane protein protective antigen OMA87 - - - - - - - - - - - - Bac_surface_Ag k59_1024150_1 1267535.KB906767_gene2492 1.75e-63 212.0 COG3517@1|root,COG3517@2|Bacteria,3Y2RM@57723|Acidobacteria,2JM5X@204432|Acidobacteriia 204432|Acidobacteriia S type VI secretion protein, EvpB VC_A0108 family - - - ko:K11900 ko02025,map02025 M00334 - - ko00000,ko00001,ko00002,ko02044 3.A.23.1 - - VipB k59_1024150_2 748280.NH8B_1114 1.83e-50 167.0 COG3516@1|root,COG3516@2|Bacteria,1R9Y7@1224|Proteobacteria,2VQ69@28216|Betaproteobacteria,2KR05@206351|Neisseriales 206351|Neisseriales S Type VI secretion system, VipA, VC_A0107 or Hcp2 - - - ko:K11901 ko02025,map02025 M00334 - - ko00000,ko00001,ko00002,ko02044 3.A.23.1 - - T6SS_VipA k59_1024150_3 1056820.KB900674_gene2504 1.23e-13 76.3 COG3515@1|root,COG3515@2|Bacteria,1MY80@1224|Proteobacteria,1T0A1@1236|Gammaproteobacteria,2PQ2X@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria S ImpA, N-terminal, type VI secretion system impA - - ko:K11902 ko02025,map02025 M00334 - - ko00000,ko00001,ko00002,ko02044 - - - ImpA_N k59_1306309_1 1168065.DOK_12286 1.06e-112 327.0 COG0684@1|root,COG0684@2|Bacteria,1MW9P@1224|Proteobacteria,1RNV3@1236|Gammaproteobacteria,1J8VD@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H COG0684 Demethylmenaquinone methyltransferase fldZ - 4.1.3.17 ko:K10218 ko00362,ko00660,ko01120,map00362,map00660,map01120 - R00008,R00350 RC00067,RC00502,RC01205 ko00000,ko00001,ko01000 - - - RraA-like k59_1306316_1 314287.GB2207_05192 8.85e-108 325.0 COG0305@1|root,COG0305@2|Bacteria,1MUG9@1224|Proteobacteria,1RPM2@1236|Gammaproteobacteria,1J4Z9@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins dnaB GO:0003674,GO:0003678,GO:0003824,GO:0004386,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006268,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009628,GO:0009987,GO:0010212,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0032392,GO:0032508,GO:0034641,GO:0034645,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051276,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360,GO:1901576 3.6.4.12 ko:K02314 ko03030,ko04112,map03030,map04112 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB,DnaB_C k59_1645317_1 1265313.HRUBRA_02301 1.85e-112 340.0 COG0204@1|root,COG0560@1|root,COG0204@2|Bacteria,COG0560@2|Bacteria,1MY51@1224|Proteobacteria,1RQYC@1236|Gammaproteobacteria,1J8AD@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria I Phosphate acyltransferases - - - - - - - - - - - - Acyltransferase,HAD k59_289632_1 555793.WSK_0875 1.34e-81 263.0 COG3808@1|root,COG3808@2|Bacteria,1MUQ3@1224|Proteobacteria,2TR9G@28211|Alphaproteobacteria,2K0XA@204457|Sphingomonadales 204457|Sphingomonadales C Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force hppA - 3.6.1.1 ko:K15987 ko00190,map00190 - - - ko00000,ko00001,ko01000 3.A.10.1 - - H_PPase k59_1198430_1 551789.ATVJ01000001_gene1072 8.31e-84 264.0 COG0481@1|root,COG0481@2|Bacteria,1MVZA@1224|Proteobacteria,2TR3H@28211|Alphaproteobacteria,43WB9@69657|Hyphomonadaceae 28211|Alphaproteobacteria M Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner lepA - - ko:K03596 ko05134,map05134 - - - ko00000,ko00001 - - - EFG_C,EFG_II,GTP_EFTU,GTP_EFTU_D2,LepA_C k59_971806_1 1415630.U771_17915 1.75e-44 153.0 COG0572@1|root,COG0572@2|Bacteria,1QY3Q@1224|Proteobacteria,1SD3A@1236|Gammaproteobacteria 1236|Gammaproteobacteria F AAA domain - - - - - - - - - - - - AAA_18 k59_971806_2 1121934.AUDX01000010_gene569 1.59e-28 112.0 COG0040@1|root,COG0040@2|Bacteria,2GNAX@201174|Actinobacteria,4FKI0@85023|Microbacteriaceae 201174|Actinobacteria E ATP phosphoribosyltransferase hisG GO:0000105,GO:0003674,GO:0003824,GO:0003879,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.17 ko:K00765,ko:K02502 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R01071 RC02819,RC03200 ko00000,ko00001,ko00002,ko01000 - - - HisG,HisG_C k59_1537781_2 504487.JCM19302_701 7.6e-115 335.0 COG0847@1|root,COG0847@2|Bacteria,4NE82@976|Bacteroidetes,1HXW3@117743|Flavobacteriia 976|Bacteroidetes L DNA polymerase III dnaQ - 2.7.7.7 ko:K02342 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - RNase_T k59_295183_1 530564.Psta_4413 5.97e-24 100.0 COG0055@1|root,COG0055@2|Bacteria,2IY7P@203682|Planctomycetes 203682|Planctomycetes C Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits atpD - 3.6.3.14 ko:K02112 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - - ATP-synt_ab,ATP-synt_ab_N k59_295183_2 886293.Sinac_6881 7.22e-19 82.8 COG0355@1|root,COG0355@2|Bacteria,2J00X@203682|Planctomycetes 203682|Planctomycetes C Produces ATP from ADP in the presence of a proton gradient across the membrane atpC GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016469,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0045259,GO:0045261,GO:0046034,GO:0046390,GO:0046483,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - ko:K02114 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt_DE_N k59_351597_1 1122137.AQXF01000005_gene1187 1.03e-150 434.0 COG0665@1|root,COG0665@2|Bacteria,1MVGP@1224|Proteobacteria,2TUMK@28211|Alphaproteobacteria 28211|Alphaproteobacteria E COG0665 Glycine D-amino acid oxidases (deaminating) ordL - - - - - - - - - - - DAO k59_1763361_1 215803.DB30_4995 5.9e-88 287.0 COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,42N8M@68525|delta/epsilon subdivisions,2WJRT@28221|Deltaproteobacteria,2YUBZ@29|Myxococcales 28221|Deltaproteobacteria F Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen nrdA1 - 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - Ribonuc_red_2_N,Ribonuc_red_lgC k59_1368572_1 555778.Hneap_1019 3.02e-63 218.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1WW0R@135613|Chromatiales 135613|Chromatiales V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K03296 - - - - ko00000 2.A.6.2 - - ACR_tran k59_1481878_1 158500.BV97_00554 4.08e-124 384.0 COG0745@1|root,COG3437@1|root,COG4251@1|root,COG0745@2|Bacteria,COG3437@2|Bacteria,COG4251@2|Bacteria,1NSQ1@1224|Proteobacteria,2TWWT@28211|Alphaproteobacteria,2KEEI@204457|Sphingomonadales 204457|Sphingomonadales T Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - - - - - - - - - - GAF_2,HATPase_c,HisKA,Response_reg k59_1198457_1 675814.VIC_004112 2.49e-80 258.0 COG0277@1|root,COG0277@2|Bacteria,1MY08@1224|Proteobacteria,1RNNT@1236|Gammaproteobacteria 1236|Gammaproteobacteria C FAD linked oxidase domain protein - - 1.17.99.1 ko:K05797 ko00623,ko01100,ko01120,map00623,map01100,map01120 - R02675,R11194 RC00769 ko00000,ko00001,ko01000 - - - FAD-oxidase_C,FAD_binding_4 k59_1593950_2 1279017.AQYJ01000027_gene1766 3.45e-24 95.9 COG0041@1|root,COG0041@2|Bacteria,1RCWJ@1224|Proteobacteria,1S3VN@1236|Gammaproteobacteria,466US@72275|Alteromonadaceae 1236|Gammaproteobacteria F Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) purE - 5.4.99.18 ko:K01588 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R07405 RC01947 ko00000,ko00001,ko00002,ko01000 - - - AIRC k59_125382_1 1122137.AQXF01000002_gene380 4.85e-201 582.0 COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,2TQK9@28211|Alphaproteobacteria 28211|Alphaproteobacteria L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate uvrA - - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - ABC_tran k59_1141873_1 391626.OAN307_c32140 5.63e-43 158.0 COG0065@1|root,COG0065@2|Bacteria,1MVYR@1224|Proteobacteria,2TT8I@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Aconitase family (aconitate hydratase) - - 4.2.1.33,4.2.1.35 ko:K01703 ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230 M00432,M00535 R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170 RC00497,RC00976,RC00977,RC01041,RC01046,RC03072 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase k59_69429_1 1027273.GZ77_11070 3.26e-16 79.7 COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,1RMM4@1236|Gammaproteobacteria,1XNEK@135619|Oceanospirillales 135619|Oceanospirillales V ATPases associated with a variety of cellular activities - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_69429_2 1026882.MAMP_01449 1.06e-20 89.0 COG1277@1|root,COG1277@2|Bacteria,1NZZ9@1224|Proteobacteria,1RP6C@1236|Gammaproteobacteria,46210@72273|Thiotrichales 72273|Thiotrichales S CcmB protein - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_2,ABC2_membrane_3 k59_1030031_1 1192124.LIG30_1791 2.34e-48 164.0 COG0604@1|root,COG0604@2|Bacteria,1R8NX@1224|Proteobacteria,2W0KY@28216|Betaproteobacteria,1K4PK@119060|Burkholderiaceae 28216|Betaproteobacteria C Alcohol dehydrogenase GroES-like domain - - 1.6.5.5 ko:K00344 - - - - ko00000,ko01000 - - - ADH_N,ADH_zinc_N_2 k59_1030031_2 649747.HMPREF0083_00287 6.54e-18 81.3 COG2318@1|root,COG2318@2|Bacteria,1V8HE@1239|Firmicutes,4HJ3X@91061|Bacilli,272R9@186822|Paenibacillaceae 91061|Bacilli S DinB family - - - - - - - - - - - - DinB,DinB_2 k59_1481901_1 765911.Thivi_3089 1.14e-104 313.0 COG0113@1|root,COG0113@2|Bacteria,1MWMW@1224|Proteobacteria,1RP6Q@1236|Gammaproteobacteria,1WW00@135613|Chromatiales 135613|Chromatiales H Belongs to the ALAD family - - 4.2.1.24 ko:K01698 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R00036 RC00918,RC01781 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ALAD k59_1255022_1 987059.RBXJA2T_08118 3.93e-27 110.0 COG0028@1|root,COG0028@2|Bacteria,1P76A@1224|Proteobacteria,2VNC6@28216|Betaproteobacteria,1KN4R@119065|unclassified Burkholderiales 28216|Betaproteobacteria EH Belongs to the TPP enzyme family - - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_1255022_2 1231185.BAMP01000002_gene4357 2.49e-21 94.0 COG3573@1|root,COG3573@2|Bacteria,1MVX8@1224|Proteobacteria,2TVKJ@28211|Alphaproteobacteria,43JC5@69277|Phyllobacteriaceae 28211|Alphaproteobacteria S FAD binding domain MA20_22130 - - ko:K07077 - - - - ko00000 - - - FAD_binding_2 k59_351630_1 1226994.AMZB01000098_gene1264 3.88e-65 214.0 COG1236@1|root,COG1236@2|Bacteria,1MUDD@1224|Proteobacteria,1RPZC@1236|Gammaproteobacteria,1YFDT@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria J Beta-Casp domain - - - ko:K07576 - - - - ko00000 - - - Beta-Casp,Lactamase_B,Lactamase_B_2,Lactamase_B_6,RMMBL k59_1481912_1 391603.FBALC1_11767 1.69e-106 332.0 COG0458@1|root,COG0458@2|Bacteria,4NEQ0@976|Bacteroidetes,1HWPA@117743|Flavobacteriia 976|Bacteroidetes EF Carbamoyl-phosphate synthase carB - 6.3.5.5 ko:K01955 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - - CPSase_L_D2,CPSase_L_D3,MGS k59_633445_1 1485545.JQLW01000005_gene925 1.35e-57 188.0 COG1773@1|root,COG1773@2|Bacteria,1MV2U@1224|Proteobacteria 1224|Proteobacteria C PFAM HupH hydrogenase expression protein hupH - - ko:K03618 - - - - ko00000 - - - HupH_C k59_1198486_2 1336208.JADY01000006_gene645 2.8e-88 274.0 COG4608@1|root,COG4608@2|Bacteria,1NU4K@1224|Proteobacteria,2TQTV@28211|Alphaproteobacteria,2JPRD@204441|Rhodospirillales 204441|Rhodospirillales E Belongs to the ABC transporter superfamily - - - ko:K10823 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00439 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 - - ABC_tran,oligo_HPY k59_578090_2 1388763.O165_020695 7.09e-18 81.3 COG0835@1|root,COG0835@2|Bacteria,1RCIR@1224|Proteobacteria,1SC4F@1236|Gammaproteobacteria,1YWEX@136845|Pseudomonas putida group 1236|Gammaproteobacteria NT PFAM CheW domain protein pilI - - ko:K02659 ko02020,ko02025,map02020,map02025 - - - ko00000,ko00001,ko02035,ko02044 - - - CheW k59_521070_1 566466.NOR53_2858 2.52e-99 295.0 COG1028@1|root,COG1028@2|Bacteria,1MXNQ@1224|Proteobacteria,1RRVQ@1236|Gammaproteobacteria,1J85B@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Belongs to the short-chain dehydrogenases reductases (SDR) family - - - - - - - - - - - - adh_short k59_690965_1 158500.BV97_02189 6.31e-109 323.0 COG1466@1|root,COG1466@2|Bacteria,1N7AB@1224|Proteobacteria,2UHPM@28211|Alphaproteobacteria,2K0ER@204457|Sphingomonadales 204457|Sphingomonadales L DNA polymerase III holA - 2.7.7.7 ko:K02340 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_delta k59_70502_1 648757.Rvan_1959 1.81e-59 187.0 2DBX8@1|root,2ZBN7@2|Bacteria,1RABM@1224|Proteobacteria,2U5PN@28211|Alphaproteobacteria,3N8F5@45401|Hyphomicrobiaceae 28211|Alphaproteobacteria S Protein of unknown function, DUF269 - - - - - - - - - - - - DUF269 k59_70502_2 743299.Acife_1641 4.88e-19 80.1 COG5420@1|root,COG5420@2|Bacteria,1N74Y@1224|Proteobacteria,1SUXK@1236|Gammaproteobacteria,2NDWX@225057|Acidithiobacillales 225057|Acidithiobacillales S Rop-like - - - - - - - - - - - - Rop-like k59_1199602_1 1123236.KB899382_gene2308 6.02e-94 281.0 COG2801@1|root,COG2801@2|Bacteria,1MVN5@1224|Proteobacteria,1RR8F@1236|Gammaproteobacteria,466E0@72275|Alteromonadaceae 1236|Gammaproteobacteria L COG2801 Transposase and inactivated derivatives - - - ko:K07497 - - - - ko00000 - - - HTH_21,rve,rve_3 k59_521089_1 1392498.JQLH01000001_gene135 5.44e-15 82.0 COG4772@1|root,COG4772@2|Bacteria,4PKRQ@976|Bacteroidetes,1HX89@117743|Flavobacteriia,2PG6K@252356|Maribacter 976|Bacteroidetes P Outer membrane protein beta-barrel family - - - - - - - - - - - - CarbopepD_reg_2,CarboxypepD_reg,OMP_b-brl_3 k59_1707674_2 290397.Adeh_1251 2.14e-23 110.0 2A7N3@1|root,30WK3@2|Bacteria,1NERD@1224|Proteobacteria,42P7M@68525|delta/epsilon subdivisions,2WJTH@28221|Deltaproteobacteria,2Z0ZJ@29|Myxococcales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_464990_1 344747.PM8797T_29283 5.43e-63 217.0 COG1251@1|root,COG2146@1|root,COG1251@2|Bacteria,COG2146@2|Bacteria,2IY23@203682|Planctomycetes 203682|Planctomycetes C nitrite reductase (NAD(P)H) large subunit - - - - - - - - - - - - Fer2_BFD,NIR_SIR,NIR_SIR_ferr,Pyr_redox_2,Rieske_2 k59_1086373_1 653733.Selin_0139 1.41e-21 97.4 COG1639@1|root,COG1639@2|Bacteria 2|Bacteria T HDOD domain - - - - - - - - - - - - HDOD k59_1142822_1 936455.KI421499_gene720 1.7e-05 52.0 COG2114@1|root,COG3899@1|root,COG2114@2|Bacteria,COG3899@2|Bacteria,1MUDT@1224|Proteobacteria,2TQVN@28211|Alphaproteobacteria,3JTQ7@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria T Adenylate and Guanylate cyclase catalytic domain - - - - - - - - - - - - AAA_16,DZR,Guanylate_cyc,SAM_1 k59_1707679_1 997346.HMPREF9374_2004 4.99e-61 199.0 COG1622@1|root,COG3474@1|root,COG1622@2|Bacteria,COG3474@2|Bacteria,1TRC3@1239|Firmicutes,4HADQ@91061|Bacilli,27BBX@186824|Thermoactinomycetaceae 91061|Bacilli C Cytochrome C oxidase subunit II, transmembrane domain - - - - - - - - - - - - COX2,COX2_TM,Cytochrom_C k59_861667_1 207954.MED92_06508 1.19e-124 378.0 COG1200@1|root,COG1200@2|Bacteria,1MWN2@1224|Proteobacteria,1RMMQ@1236|Gammaproteobacteria,1XIN2@135619|Oceanospirillales 135619|Oceanospirillales L Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) recG - 3.6.4.12 ko:K03655 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,Helicase_C,RecG_wedge k59_1199620_1 243233.MCA2852 7.33e-188 540.0 COG1217@1|root,COG1217@2|Bacteria,1MV5Q@1224|Proteobacteria,1RMJB@1236|Gammaproteobacteria,1XEI7@135618|Methylococcales 135618|Methylococcales T GTP-binding protein TypA typA - - ko:K06207 - - - - ko00000 - - - EFG_C,GTP_EFTU,GTP_EFTU_D2 k59_1199620_2 391593.RCCS2_04939 2.57e-14 72.8 COG1162@1|root,COG1162@2|Bacteria,1MUEF@1224|Proteobacteria,2TR5R@28211|Alphaproteobacteria,2P2JH@2433|Roseobacter 28211|Alphaproteobacteria S One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit rsgA - 3.1.3.100 ko:K06949 ko00730,ko01100,map00730,map01100 - R00615,R02135 RC00002,RC00017 ko00000,ko00001,ko01000,ko03009 - - - RsgA_GTPase k59_634635_1 1323663.AROI01000003_gene2269 2.69e-77 245.0 COG0541@1|root,COG0541@2|Bacteria,1MVIA@1224|Proteobacteria,1RMU9@1236|Gammaproteobacteria 1236|Gammaproteobacteria U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components ffh GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006605,GO:0006612,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0032991,GO:0033036,GO:0034613,GO:0035639,GO:0036094,GO:0042886,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0045184,GO:0046907,GO:0048500,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0070727,GO:0071702,GO:0071705,GO:0072657,GO:0090150,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1990904 3.6.5.4 ko:K03106 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko01000,ko02044 3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9 - - SRP54,SRP54_N,SRP_SPB k59_1764549_1 748247.AZKH_4303 1.59e-16 76.6 COG0603@1|root,COG0603@2|Bacteria,1MU5V@1224|Proteobacteria,2VHY3@28216|Betaproteobacteria,2KVAA@206389|Rhodocyclales 206389|Rhodocyclales F Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) queC - 6.3.4.20 ko:K06920 ko00790,ko01100,map00790,map01100 - R09978 RC00959 ko00000,ko00001,ko01000,ko03016 - - - QueC k59_1764549_2 395495.Lcho_3776 1.65e-27 110.0 COG2391@1|root,COG2391@2|Bacteria,1MXSE@1224|Proteobacteria,2VKGG@28216|Betaproteobacteria,1KNC0@119065|unclassified Burkholderiales 28216|Betaproteobacteria S Sulphur transport - - - ko:K07112 - - - - ko00000 - - - Sulf_transp k59_465015_1 1298593.TOL_2863 6.84e-23 97.1 COG0564@1|root,COG0564@2|Bacteria,1MUBN@1224|Proteobacteria,1RN7F@1236|Gammaproteobacteria,1XHHX@135619|Oceanospirillales 135619|Oceanospirillales J Responsible for synthesis of pseudouridine from uracil rluD - 5.4.99.23 ko:K06180 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2,S4 k59_465015_2 1415778.JQMM01000001_gene1235 8.74e-20 87.8 COG4105@1|root,COG4105@2|Bacteria,1MVS5@1224|Proteobacteria,1RSE6@1236|Gammaproteobacteria,1J5AA@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane bamD GO:0005575,GO:0005623,GO:0008104,GO:0008150,GO:0009279,GO:0009987,GO:0016020,GO:0016043,GO:0019867,GO:0022607,GO:0030312,GO:0030313,GO:0031224,GO:0031230,GO:0031241,GO:0031246,GO:0031975,GO:0032991,GO:0033036,GO:0034613,GO:0043163,GO:0043165,GO:0044085,GO:0044091,GO:0044425,GO:0044462,GO:0044464,GO:0045184,GO:0045229,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0061024,GO:0070727,GO:0071709,GO:0071840,GO:0071944,GO:0072657,GO:0090150,GO:0098552,GO:0098796,GO:1990063 - ko:K05807 - - - - ko00000,ko02000 1.B.33.1 - - YfiO k59_972771_1 748280.NH8B_3470 1.63e-82 262.0 COG0358@1|root,COG0358@2|Bacteria,1MUHC@1224|Proteobacteria,2VHI9@28216|Betaproteobacteria,2KQ3T@206351|Neisseriales 206351|Neisseriales L RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication dnaG - - ko:K02316 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB_bind,DnaG_DnaB_bind,Toprim_2,Toprim_4,Toprim_N,zf-CHC2 k59_1651916_1 1123368.AUIS01000018_gene704 2.31e-17 76.3 COG1539@1|root,COG1539@2|Bacteria,1MZ8Z@1224|Proteobacteria,1S9B2@1236|Gammaproteobacteria,2ND0H@225057|Acidithiobacillales 225057|Acidithiobacillales H Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin - - 1.13.11.81,4.1.2.25,5.1.99.8 ko:K01633 ko00790,ko01100,map00790,map01100 M00126,M00840 R03504,R11037,R11073 RC00721,RC00943,RC01479,RC03333,RC03334 ko00000,ko00001,ko00002,ko01000 - - - FolB k59_1651916_2 882378.RBRH_01159 1.13e-19 89.7 COG0533@1|root,COG0533@2|Bacteria,1MU6S@1224|Proteobacteria,2VHDR@28216|Betaproteobacteria,1K0V6@119060|Burkholderiaceae 28216|Betaproteobacteria J Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction tsaD - 2.3.1.234 ko:K01409 - - R10648 RC00070,RC00416 ko00000,ko01000,ko03016 - - - Peptidase_M22 k59_1199646_1 640081.Dsui_2544 1.35e-10 61.6 COG1281@1|root,COG1281@2|Bacteria,1MUMU@1224|Proteobacteria,2VI8B@28216|Betaproteobacteria,2KVFH@206389|Rhodocyclales 206389|Rhodocyclales O Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress - - - ko:K04083 - - - - ko00000,ko03110 - - - HSP33 k59_1199646_2 420662.Mpe_A3698 1.64e-32 118.0 COG2030@1|root,COG2030@2|Bacteria,1RIBV@1224|Proteobacteria,2VTGX@28216|Betaproteobacteria,1KKWK@119065|unclassified Burkholderiales 28216|Betaproteobacteria I dehydratase - - - - - - - - - - - - MaoC_dehydratas k59_1313143_1 477184.KYC_12208 1.39e-67 211.0 COG1802@1|root,COG1802@2|Bacteria,1RDCR@1224|Proteobacteria,2W242@28216|Betaproteobacteria,3T7XP@506|Alcaligenaceae 28216|Betaproteobacteria K FCD - - - - - - - - - - - - FCD,GntR k59_1256011_1 1229909.NSED_06055 3.41e-24 101.0 COG3391@1|root,arCOG02562@2157|Archaea,41T9S@651137|Thaumarchaeota 651137|Thaumarchaeota S TIGRFAM 40-residue YVTN family beta-propeller repeat - - - - - - - - - - - - Lactonase k59_1142840_2 1385935.N836_12085 3.81e-36 129.0 COG0225@1|root,COG0225@2|Bacteria,1G1QF@1117|Cyanobacteria,1H72I@1150|Oscillatoriales 1117|Cyanobacteria O Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine msrA - 1.8.4.11 ko:K07304 - - - - ko00000,ko01000 - - - PMSR k59_1313149_1 1392490.JHZX01000001_gene2471 9.02e-122 370.0 COG1472@1|root,COG1472@2|Bacteria,4NE90@976|Bacteroidetes,1HX27@117743|Flavobacteriia 976|Bacteroidetes G Belongs to the glycosyl hydrolase 3 family - - 3.2.1.21 ko:K05349 ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110 - R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040 RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248 ko00000,ko00001,ko01000 - GH3 - Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C k59_578132_1 378806.STAUR_3100 1.06e-68 224.0 COG3344@1|root,COG3344@2|Bacteria,1MVI1@1224|Proteobacteria,42Y93@68525|delta/epsilon subdivisions,2WU1Y@28221|Deltaproteobacteria,2YTTS@29|Myxococcales 28221|Deltaproteobacteria H Reverse transcriptase (RNA-dependent DNA polymerase) - - - - - - - - - - - - GIIM,RVT_1 k59_1199665_1 1121377.KB906413_gene4213 1e-17 80.1 COG5513@1|root,COG5513@2|Bacteria,1WN5E@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus S Chagasin family peptidase inhibitor I42 - - - - - - - - - - - - Inhibitor_I42 k59_1595019_1 715226.ABI_13050 3.84e-44 170.0 COG3209@1|root,COG3209@2|Bacteria,1MVV1@1224|Proteobacteria,2UBV3@28211|Alphaproteobacteria 28211|Alphaproteobacteria M COG3209 Rhs family protein - - - - - - - - - - - - LysM,RHS_repeat k59_691044_1 876044.IMCC3088_982 1.01e-95 285.0 COG0500@1|root,COG2226@2|Bacteria,1MX8I@1224|Proteobacteria,1RMAU@1236|Gammaproteobacteria,1J4ZD@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2- polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) ubiE GO:0003674,GO:0003824,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008425,GO:0008757,GO:0009058,GO:0009108,GO:0009233,GO:0009234,GO:0009987,GO:0016740,GO:0016741,GO:0030580,GO:0032259,GO:0042180,GO:0042181,GO:0043333,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901661,GO:1901663 2.1.1.163,2.1.1.201 ko:K03183 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116,M00117 R04990,R04993,R06859,R08774,R09736 RC00003,RC01253,RC01662 ko00000,ko00001,ko00002,ko01000 - - iAF1260.b3833,iBWG_1329.BWG_3511,iE2348C_1286.E2348C_4147,iEC042_1314.EC042_4213,iEC55989_1330.EC55989_4310,iECDH10B_1368.ECDH10B_4024,iECDH1ME8569_1439.ECDH1ME8569_3712,iECH74115_1262.ECH74115_5274,iECIAI1_1343.ECIAI1_4028,iECIAI39_1322.ECIAI39_3162,iECO103_1326.ECO103_4330,iECO111_1330.ECO111_4661,iECO26_1355.ECO26_4752,iECSE_1348.ECSE_4121,iECSP_1301.ECSP_4888,iECUMN_1333.ECUMN_4359,iECW_1372.ECW_m4135,iECs_1301.ECs4763,iEKO11_1354.EKO11_4524,iETEC_1333.ETEC_4110,iEcDH1_1363.EcDH1_4146,iEcE24377_1341.EcE24377A_4354,iEcHS_1320.EcHS_A4057,iEcSMS35_1347.EcSMS35_4216,iEcolC_1368.EcolC_4175,iG2583_1286.G2583_4633,iJO1366.b3833,iJR904.b3833,iSBO_1134.SBO_3847,iSDY_1059.SDY_3910,iSFV_1184.SFV_3665,iSF_1195.SF3911,iSFxv_1172.SFxv_4263,iSSON_1240.SSON_4008,iS_1188.S3843,iSbBS512_1146.SbBS512_E4305,iUMNK88_1353.UMNK88_4663,iWFL_1372.ECW_m4135,iY75_1357.Y75_RS17910,iZ_1308.Z5355 Ubie_methyltran k59_352824_2 926550.CLDAP_39200 1.35e-70 227.0 COG1249@1|root,COG1249@2|Bacteria,2G5MR@200795|Chloroflexi 200795|Chloroflexi C Pyridine nucleotide-disulphide oxidoreductase dimerisation region lpd - 1.8.1.4 ko:K00382 ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00036,M00307,M00532 R00209,R01221,R01698,R03815,R07618,R08549 RC00004,RC00022,RC00583,RC02742,RC02833,RC02834 br01601,ko00000,ko00001,ko00002,ko01000,ko04147 - - - Pyr_redox_2,Pyr_redox_dim k59_1086407_1 314230.DSM3645_02393 1.52e-86 268.0 COG0160@1|root,COG0160@2|Bacteria,2IXU3@203682|Planctomycetes 203682|Planctomycetes H Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family - - 2.6.1.76 ko:K00836 ko00260,ko01100,ko01120,ko01210,ko01230,map00260,map01100,map01120,map01210,map01230 M00033 R06977 RC00006,RC00062 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 k59_691045_1 190650.CC_0978 3.19e-70 239.0 COG3408@1|root,COG3408@2|Bacteria,1NJCP@1224|Proteobacteria,2U1JA@28211|Alphaproteobacteria,2KI0F@204458|Caulobacterales 204458|Caulobacterales G Bacterial alpha-L-rhamnosidase C-terminal domain - - 3.2.1.40 ko:K05989 - - - - ko00000,ko01000 - - - Bac_rhamnosid,Bac_rhamnosid6H,Bac_rhamnosid_C,Bac_rhamnosid_N k59_1425301_1 1415756.JQMY01000001_gene2711 1.87e-93 282.0 COG1226@1|root,COG1226@2|Bacteria,1QYC1@1224|Proteobacteria,2TXMV@28211|Alphaproteobacteria 28211|Alphaproteobacteria P COG1226 Kef-type K transport systems - - - ko:K10716 - - - - ko00000,ko02000 1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6 - - Ion_trans,Ion_trans_2 k59_1764568_1 436308.Nmar_0440 5.21e-155 439.0 COG0061@1|root,arCOG01348@2157|Archaea,41SHP@651137|Thaumarchaeota 651137|Thaumarchaeota H Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP - - 2.7.1.23 ko:K00858 ko00760,ko01100,map00760,map01100 - R00104 RC00002,RC00078 ko00000,ko00001,ko01000 - - - NAD_kinase k59_465049_1 1502852.FG94_00854 2.93e-28 111.0 COG1284@1|root,COG1284@2|Bacteria,1RDIV@1224|Proteobacteria,2VQSX@28216|Betaproteobacteria,475I1@75682|Oxalobacteraceae 28216|Betaproteobacteria S Uncharacterised 5xTM membrane BCR, YitT family COG1284 - - - - - - - - - - - - YitT_membrane k59_1483038_1 1429916.X566_16150 1.6e-45 157.0 COG2301@1|root,COG2301@2|Bacteria,1MW0A@1224|Proteobacteria,2U6H0@28211|Alphaproteobacteria,3K62H@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria G HpcH/HpaI aldolase/citrate lyase family - - 4.1.3.34 ko:K01644 ko02020,map02020 - R00362 RC00067,RC01118 ko00000,ko00001,ko01000 - - - HpcH_HpaI k59_1256046_1 1254432.SCE1572_12055 2.32e-20 95.9 COG0515@1|root,COG2203@1|root,COG3899@1|root,COG4191@1|root,COG0515@2|Bacteria,COG2203@2|Bacteria,COG3899@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,43BKN@68525|delta/epsilon subdivisions,2WJNS@28221|Deltaproteobacteria,2YXZU@29|Myxococcales 28221|Deltaproteobacteria KLT Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - - - - - - - - - - AAA_16,GAF,HATPase_c,HisKA,Pkinase k59_521176_1 526225.Gobs_1173 9.17e-06 52.4 COG3509@1|root,COG3509@2|Bacteria,2GMTA@201174|Actinobacteria,4EX4P@85013|Frankiales 201174|Actinobacteria Q TIGRFAM esterase, PHB depolymerase family phaZ1 - 3.1.1.72 ko:K05972 - - - - ko00000,ko01000 - - - CBM_2,Esterase_phd,RicinB_lectin_2,Ricin_B_lectin k59_804700_1 1121106.JQKB01000038_gene658 4.34e-05 49.7 COG2072@1|root,COG2072@2|Bacteria,1MUQH@1224|Proteobacteria,2TRG4@28211|Alphaproteobacteria 28211|Alphaproteobacteria P Flavoprotein involved in K transport MA20_14940 - 1.14.13.84 ko:K14520 ko00363,ko01100,ko01120,map00363,map01100,map01120 - R06892 RC01644 ko00000,ko00001,ko01000 - - - FMO-like,K_oxygenase,NAD_binding_8,Pyr_redox_3 k59_182941_1 1121937.AUHJ01000001_gene348 3.56e-14 71.6 COG1115@1|root,COG1115@2|Bacteria,1MUI3@1224|Proteobacteria,1RMNF@1236|Gammaproteobacteria,464Z4@72275|Alteromonadaceae 1236|Gammaproteobacteria E alanine symporter dagA - - ko:K03310 - - - - ko00000 2.A.25 - - Na_Ala_symp k59_182941_2 1265313.HRUBRA_01871 2.57e-29 117.0 COG0427@1|root,COG0427@2|Bacteria,1PJY0@1224|Proteobacteria,1RPS6@1236|Gammaproteobacteria,1J4RG@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Acetyl-CoA hydrolase - - - - - - - - - - - - AcetylCoA_hyd_C k59_126606_1 3067.XP_002947376.1 1.13e-05 48.1 COG0408@1|root,KOG1518@2759|Eukaryota,37NFJ@33090|Viridiplantae,34GSY@3041|Chlorophyta 3041|Chlorophyta H coproporphyrinogen III oxidase HEMF - 1.3.3.3 ko:K00228 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R03220 RC00884 ko00000,ko00001,ko00002,ko01000 - - - Coprogen_oxidas k59_126606_2 232721.Ajs_1899 3.34e-117 348.0 COG0151@1|root,COG0151@2|Bacteria,1MUAH@1224|Proteobacteria,2VH9J@28216|Betaproteobacteria,4A9X8@80864|Comamonadaceae 28216|Betaproteobacteria F Belongs to the GARS family purD - 6.3.4.13 ko:K01945 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04144 RC00090,RC00166 ko00000,ko00001,ko00002,ko01000 - - - GARS_A,GARS_C,GARS_N k59_70585_1 1209072.ALBT01000029_gene2239 1.5e-123 358.0 COG0548@1|root,COG0548@2|Bacteria,1MU17@1224|Proteobacteria,1RNKK@1236|Gammaproteobacteria,1FGPZ@10|Cellvibrio 1236|Gammaproteobacteria F Belongs to the acetylglutamate kinase family. ArgB subfamily argB GO:0003674,GO:0003824,GO:0003991,GO:0004042,GO:0005488,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0008080,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016407,GO:0016410,GO:0016597,GO:0016740,GO:0016746,GO:0016747,GO:0016772,GO:0016774,GO:0019752,GO:0031406,GO:0033554,GO:0034618,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0050896,GO:0051716,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.3.1.1,2.7.2.8 ko:K00930,ko:K22478 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028,M00845 R00259,R02649 RC00002,RC00004,RC00043,RC00064 ko00000,ko00001,ko00002,ko01000 - - iAPECO1_1312.APECO1_2508,iB21_1397.B21_03793,iEC55989_1330.EC55989_4441,iECB_1328.ECB_03844,iECDH10B_1368.ECDH10B_4147,iECDH1ME8569_1439.ECDH1ME8569_3827,iECD_1391.ECD_03844,iECH74115_1262.ECH74115_5419,iECIAI1_1343.ECIAI1_4167,iECO103_1326.ECO103_4715,iECOK1_1307.ECOK1_4431,iECS88_1305.ECS88_4414,iECSE_1348.ECSE_4252,iETEC_1333.ETEC_4227,iEcE24377_1341.EcE24377A_4498,iEcHS_1320.EcHS_A4193,iEcolC_1368.EcolC_4057,iSbBS512_1146.SbBS512_E4445,iUMN146_1321.UM146_20050,iUMNK88_1353.UMNK88_4797,iUTI89_1310.UTI89_C4550,iY75_1357.Y75_RS17255 AA_kinase,NAT k59_578164_1 1380387.JADM01000029_gene3680 1.31e-09 56.6 COG0244@1|root,COG0244@2|Bacteria,1RAN5@1224|Proteobacteria,1S286@1236|Gammaproteobacteria,1XJFF@135619|Oceanospirillales 135619|Oceanospirillales J Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors rplJ - - ko:K02864 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L10 k59_578164_2 568706.BN118_0013 3.36e-38 132.0 COG0222@1|root,COG0222@2|Bacteria,1RGU4@1224|Proteobacteria,2VSG7@28216|Betaproteobacteria,3T44Z@506|Alcaligenaceae 28216|Betaproteobacteria J Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation rplL - - ko:K02935 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L12,Ribosomal_L12_N k59_972819_1 509190.Cseg_1249 1.39e-08 60.8 COG1680@1|root,COG1680@2|Bacteria,1MVPR@1224|Proteobacteria,2UE6N@28211|Alphaproteobacteria,2KI5A@204458|Caulobacterales 204458|Caulobacterales V Beta-lactamase - - - - - - - - - - - - Beta-lactamase k59_1651987_1 1229909.NSED_01965 8.52e-127 367.0 COG0130@1|root,arCOG00987@2157|Archaea,41S8E@651137|Thaumarchaeota 651137|Thaumarchaeota J Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs truB - - ko:K11131 ko03008,map03008 M00425 - - ko00000,ko00001,ko00002,ko01000,ko03009,ko03032 - - - DKCLD,PUA,TruB_C_2,TruB_N k59_1262806_1 436308.Nmar_0067 6.58e-126 387.0 COG1615@1|root,arCOG06128@2157|Archaea,41SCS@651137|Thaumarchaeota 651137|Thaumarchaeota S Uncharacterised protein family (UPF0182) - - - ko:K09118 - - - - ko00000 - - - UPF0182 k59_190342_1 1096930.L284_23450 9.85e-25 102.0 COG0038@1|root,COG0517@1|root,COG0038@2|Bacteria,COG0517@2|Bacteria,1MV4K@1224|Proteobacteria,2TTBG@28211|Alphaproteobacteria,2K15J@204457|Sphingomonadales 204457|Sphingomonadales P Chloride channel - - - ko:K03281 - - - - ko00000 2.A.49 - - CBS,Voltage_CLC k59_190342_2 1144305.PMI02_01225 3.55e-83 250.0 COG0847@1|root,COG0847@2|Bacteria,1RHD8@1224|Proteobacteria,2UFQU@28211|Alphaproteobacteria,2KDDW@204457|Sphingomonadales 204457|Sphingomonadales L DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease - - - - - - - - - - - - - k59_1490209_1 1279038.KB907350_gene2860 4.88e-45 160.0 COG0174@1|root,COG0174@2|Bacteria,1MU6V@1224|Proteobacteria,2TTPD@28211|Alphaproteobacteria,2JQ42@204441|Rhodospirillales 204441|Rhodospirillales E Glutamine synthetase, catalytic domain puuA - 6.3.1.2 ko:K01915 ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 - R00253 RC00010,RC02798 ko00000,ko00001,ko01000,ko04147 - - - Gln-synt_C k59_1207124_1 887062.HGR_05439 2.03e-23 94.0 COG3040@1|root,COG3040@2|Bacteria,1RIKA@1224|Proteobacteria,2VTSY@28216|Betaproteobacteria,4AJFE@80864|Comamonadaceae 28216|Betaproteobacteria M Lipocalin-like domain - - - ko:K03098 - - - - ko00000,ko04147 - - - Lipocalin_2 k59_1207124_2 335659.S23_33160 4.71e-38 140.0 COG2907@1|root,COG2907@2|Bacteria,1MV4Z@1224|Proteobacteria,2TQUH@28211|Alphaproteobacteria,3JU95@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S Flavin containing amine oxidoreductase - - - ko:K06954 - - - - ko00000 - - - Amino_oxidase k59_527987_1 426117.M446_1651 5.97e-11 62.0 COG2987@1|root,COG2987@2|Bacteria,1MU4W@1224|Proteobacteria,2TSJR@28211|Alphaproteobacteria,1JT4U@119045|Methylobacteriaceae 28211|Alphaproteobacteria E Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate hutU - 4.2.1.49 ko:K01712 ko00340,ko01100,map00340,map01100 M00045 R02914 RC00804 ko00000,ko00001,ko00002,ko01000 - - - Urocanase,Urocanase_C,Urocanase_N k59_527987_2 596154.Alide2_1690 1.27e-78 254.0 COG2986@1|root,COG2986@2|Bacteria,1MU6K@1224|Proteobacteria,2VJB1@28216|Betaproteobacteria,4AAID@80864|Comamonadaceae 28216|Betaproteobacteria E Histidine ammonia-lyase hutH - 4.3.1.3 ko:K01745 ko00340,ko01100,map00340,map01100 M00045 R01168 RC00361 ko00000,ko00001,ko00002,ko01000 - - - Lyase_aromatic k59_20891_1 596151.DesfrDRAFT_1174 4.9e-08 61.6 COG0758@1|root,COG0758@2|Bacteria,1R9P1@1224|Proteobacteria,43DNP@68525|delta/epsilon subdivisions,2X6M7@28221|Deltaproteobacteria,2MDRZ@213115|Desulfovibrionales 28221|Deltaproteobacteria LU DNA mediated transformation - - - - - - - - - - - - - k59_1602627_1 1229909.NSED_01330 2.81e-134 393.0 COG1007@1|root,arCOG01540@2157|Archaea,41SDU@651137|Thaumarchaeota 651137|Thaumarchaeota C NADH ubiquinone oxidoreductase subunit 2 (Chain N) - - 1.5.98.3 ko:K22169 - - - - ko00000,ko01000 3.D.9.1 - - Proton_antipo_M k59_1150257_1 713587.THITH_06460 1.11e-14 78.6 COG0664@1|root,COG0664@2|Bacteria,1MVGE@1224|Proteobacteria,1RPTB@1236|Gammaproteobacteria,1WWQ7@135613|Chromatiales 135613|Chromatiales K Transcriptional regulator - - - ko:K01420 - - - - ko00000,ko03000 - - - HTH_Crp_2,cNMP_binding k59_360429_1 876044.IMCC3088_699 1.49e-197 549.0 COG0399@1|root,COG0399@2|Bacteria,1N3NC@1224|Proteobacteria,1SAHP@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Putative transposase - - - - - - - - - - - - Y2_Tnp k59_1490218_1 589873.EP13_03305 1.09e-61 203.0 2C3QV@1|root,2Z7YP@2|Bacteria,1MXAM@1224|Proteobacteria,1RNIA@1236|Gammaproteobacteria,4662K@72275|Alteromonadaceae 1236|Gammaproteobacteria S Alginate export - - - - - - - - - - - - Alginate_exp k59_698598_1 980584.AFPB01000161_gene2099 2.43e-06 48.5 COG4974@1|root,COG4974@2|Bacteria,4NE0E@976|Bacteroidetes,1HYPM@117743|Flavobacteriia,4062A@61432|unclassified Flavobacteriaceae 976|Bacteroidetes L Phage integrase, N-terminal SAM-like domain xerC - - ko:K04763 - - - - ko00000,ko03036 - - - Phage_int_SAM_1,Phage_integrase k59_698598_2 1137281.D778_01345 5.01e-61 194.0 2DRNY@1|root,32URC@2|Bacteria,4NST3@976|Bacteroidetes,1I448@117743|Flavobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - OMP_b-brl k59_979822_1 472759.Nhal_1401 2.46e-73 240.0 COG0028@1|root,COG0028@2|Bacteria,1QMA9@1224|Proteobacteria,1RRRN@1236|Gammaproteobacteria,1X05R@135613|Chromatiales 135613|Chromatiales EH Belongs to the TPP enzyme family - - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_78259_1 196162.Noca_0279 5.02e-140 413.0 COG0069@1|root,COG0069@2|Bacteria,2GME2@201174|Actinobacteria,4DPY5@85009|Propionibacteriales 201174|Actinobacteria E Conserved region in glutamate synthase gltB_1 - 1.4.7.1 ko:K00284 ko00630,ko00910,ko01120,map00630,map00910,map01120 - R00021,R10086 RC00006,RC00010 ko00000,ko00001,ko01000 - - - Glu_synthase k59_20902_1 234267.Acid_0760 1.97e-27 112.0 COG0784@1|root,COG4191@1|root,COG0784@2|Bacteria,COG4191@2|Bacteria 2|Bacteria T Histidine kinase - - - - - - - - - - - - HATPase_c,HisKA,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg,dCache_1 k59_20902_2 1499967.BAYZ01000187_gene3864 3.66e-45 150.0 COG1293@1|root,COG1293@2|Bacteria 2|Bacteria K actin binding - - - - - - - - - - - - DUF814,FbpA k59_303872_1 762903.Pedsa_3566 9.46e-26 102.0 COG3132@1|root,COG3132@2|Bacteria,4NG7X@976|Bacteroidetes,1IRRC@117747|Sphingobacteriia 976|Bacteroidetes S Belongs to the UPF0502 family - - - ko:K09915 - - - - ko00000 - - - DUF480 k59_869056_1 1122137.AQXF01000002_gene88 1.62e-216 607.0 COG0034@1|root,COG0034@2|Bacteria,1MU0V@1224|Proteobacteria,2TR8V@28211|Alphaproteobacteria 28211|Alphaproteobacteria F Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine purF GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0009507,GO:0009536,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464 2.4.2.14 ko:K00764 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048 R01072 RC00010,RC02724,RC02752 ko00000,ko00001,ko00002,ko01000,ko01002 - - - GATase_6,GATase_7,Pribosyltran k59_1602648_1 583355.Caka_1495 1.6e-57 196.0 COG5607@1|root,COG5607@2|Bacteria,46UKR@74201|Verrucomicrobia 74201|Verrucomicrobia S CHAD - - - - - - - - - - - - CHAD k59_303882_1 1121897.AUGO01000001_gene1625 2.53e-70 231.0 COG2885@1|root,COG2885@2|Bacteria,4NE6G@976|Bacteroidetes,1HXNY@117743|Flavobacteriia,2NSMW@237|Flavobacterium 976|Bacteroidetes M Belongs to the ompA family - - - - - - - - - - - - CarboxypepD_reg,OmpA,PD40 k59_1602661_1 317655.Sala_2882 1.57e-12 73.6 COG1629@1|root,COG4771@2|Bacteria,1MWKN@1224|Proteobacteria,2TTFY@28211|Alphaproteobacteria,2K075@204457|Sphingomonadales 204457|Sphingomonadales P receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_133854_1 91464.S7335_612 4.21e-94 298.0 COG0028@1|root,COG0028@2|Bacteria,1G0KQ@1117|Cyanobacteria,1GYI7@1129|Synechococcus 1117|Cyanobacteria EH Belongs to the TPP enzyme family ilvB - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_303888_1 1229909.NSED_08945 8.51e-05 51.2 COG4257@1|root,arCOG06267@1|root,arCOG03564@2157|Archaea,arCOG06267@2157|Archaea,41S5S@651137|Thaumarchaeota 651137|Thaumarchaeota V resistance protein - - - ko:K14166 - - - - ko00000,ko02000 - - - CopC,CopD k59_924368_1 1173026.Glo7428_3943 3.17e-84 281.0 COG0737@1|root,COG2931@1|root,COG3391@1|root,COG0737@2|Bacteria,COG2931@2|Bacteria,COG3391@2|Bacteria,1G0YK@1117|Cyanobacteria 1117|Cyanobacteria K phosphatase - - - - - - - - - - - - 5_nucleotid_C,CHRD,DUF4114,DUF4214,Exo_endo_phos,Phytase-like,W_rich_C k59_869075_1 158500.BV97_03974 9.32e-45 157.0 COG2256@1|root,COG2256@2|Bacteria,1MUVS@1224|Proteobacteria,2TQVF@28211|Alphaproteobacteria,2K1Z2@204457|Sphingomonadales 204457|Sphingomonadales L ATPase related to the helicase subunit of the Holliday junction resolvase - - - ko:K07478 - - - - ko00000 - - - AAA,AAA_assoc_2,MgsA_C,RuvB_N k59_869075_2 983920.Y88_0154 3.95e-22 93.6 2CF7S@1|root,32S1E@2|Bacteria,1R918@1224|Proteobacteria,2U3VN@28211|Alphaproteobacteria,2K2C5@204457|Sphingomonadales 204457|Sphingomonadales - - - - - - - - - - - - - - - k59_133865_1 745718.JADT01000003_gene2136 5.67e-14 71.2 2BWG8@1|root,2Z8GJ@2|Bacteria,4NEM1@976|Bacteroidetes,1I0BJ@117743|Flavobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_924376_1 1229909.NSED_01970 1.12e-44 149.0 arCOG07571@1|root,arCOG07571@2157|Archaea,41T4H@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_924376_2 1229909.NSED_01965 2.3e-86 263.0 COG0130@1|root,arCOG00987@2157|Archaea,41S8E@651137|Thaumarchaeota 651137|Thaumarchaeota J Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs truB - - ko:K11131 ko03008,map03008 M00425 - - ko00000,ko00001,ko00002,ko01000,ko03009,ko03032 - - - DKCLD,PUA,TruB_C_2,TruB_N k59_190391_1 247633.GP2143_04475 1.01e-24 99.0 COG1905@1|root,COG1905@2|Bacteria,1RHBU@1224|Proteobacteria,1T09A@1236|Gammaproteobacteria,1JA96@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C COG1905 NADH ubiquinone oxidoreductase 24 kD subunit - - 1.6.5.3 ko:K00127,ko:K00334 ko00190,ko00630,ko00680,ko01100,ko01120,ko01200,map00190,map00630,map00680,map01100,map01120,map01200 M00144 R00519,R11945 RC00061,RC02796 ko00000,ko00001,ko00002,ko01000 3.D.1 - - 2Fe-2S_thioredx k59_190391_2 745014.OMB55_00012650 1.8e-18 85.5 COG1894@1|root,COG1894@2|Bacteria,1MV8F@1224|Proteobacteria,1RMUD@1236|Gammaproteobacteria,1J9NX@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C NADH ubiquinone oxidoreductase, NADH-binding (51 kD) subunit fdsB - - ko:K00124 ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200 - R00519 RC02796 ko00000,ko00001 - - - Complex1_51K,NADH_4Fe-4S,SLBB k59_1490269_1 195250.CM001776_gene2956 2.17e-28 105.0 COG3118@1|root,COG3118@2|Bacteria,1G6KZ@1117|Cyanobacteria,1H0EV@1129|Synechococcus 1117|Cyanobacteria O Belongs to the thioredoxin family trxA GO:0003674,GO:0003824,GO:0004791,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0015035,GO:0015036,GO:0016209,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0016671,GO:0019725,GO:0033554,GO:0034599,GO:0042221,GO:0042592,GO:0044424,GO:0044464,GO:0045454,GO:0047134,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0055114,GO:0065007,GO:0065008,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1990748 - ko:K03671 ko04621,ko05418,map04621,map05418 - - - ko00000,ko00001,ko03110 - - - Thioredoxin k59_1490269_2 269796.Rru_A0575 1.21e-44 158.0 COG0312@1|root,COG0312@2|Bacteria,1MUVW@1224|Proteobacteria,2TSAV@28211|Alphaproteobacteria,2JQGM@204441|Rhodospirillales 204441|Rhodospirillales S Zn-dependent proteases and their inactivated homologs pmbA - - ko:K03592 - - - - ko00000,ko01002 - - - PmbA_TldD k59_190392_2 1229909.NSED_07875 6.03e-46 149.0 COG3432@1|root,arCOG01055@2157|Archaea,41SST@651137|Thaumarchaeota 651137|Thaumarchaeota K Winged helix-turn-helix - - - - - - - - - - - - HTH_45 k59_1771541_1 365044.Pnap_2983 2.15e-10 67.4 COG0530@1|root,COG0530@2|Bacteria,1PW8G@1224|Proteobacteria,2VMK4@28216|Betaproteobacteria,4AJD4@80864|Comamonadaceae 28216|Betaproteobacteria P Sodium/calcium exchanger protein - - - ko:K07301 - - - - ko00000,ko02000 2.A.19.5 - - Na_Ca_ex k59_415917_1 264732.Moth_1244 1.7e-83 261.0 COG0001@1|root,COG0001@2|Bacteria,1TPNH@1239|Firmicutes,248II@186801|Clostridia,42EMC@68295|Thermoanaerobacterales 186801|Clostridia H PFAM aminotransferase class-III hemL - 5.4.3.8 ko:K01845 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R02272 RC00677 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 k59_1093681_1 436308.Nmar_1421 2.06e-53 172.0 arCOG08772@1|root,arCOG08772@2157|Archaea,41SSX@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1093681_2 1229909.NSED_07805 9.84e-51 162.0 arCOG10584@1|root,arCOG10584@2157|Archaea,41SV6@651137|Thaumarchaeota 651137|Thaumarchaeota S Bacterial Fe(2+) trafficking - - - - - - - - - - - - Iron_traffic k59_1093681_3 436308.Nmar_0104 8.74e-36 125.0 arCOG10515@1|root,arCOG10515@2157|Archaea,41TAP@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1093681_4 1229909.NSED_07810 2.65e-17 73.9 arCOG08687@1|root,arCOG08687@2157|Archaea,41SVF@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_585503_1 1415778.JQMM01000001_gene580 1.52e-153 440.0 COG1652@1|root,COG1652@2|Bacteria,1MUBV@1224|Proteobacteria,1RPMB@1236|Gammaproteobacteria,1J4FR@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S protein containing LysM domain lysM - - - - - - - - - - - LysM k59_303925_1 565045.NOR51B_2574 7.75e-61 206.0 COG4993@1|root,COG4993@2|Bacteria,1MUQX@1224|Proteobacteria,1RN5D@1236|Gammaproteobacteria 1236|Gammaproteobacteria G Dehydrogenase - - - - - - - - - - - - PQQ,PQQ_2 k59_1150330_1 35754.JNYJ01000057_gene8708 1.28e-05 51.2 COG1317@1|root,COG1317@2|Bacteria,2IRIT@201174|Actinobacteria,4DF81@85008|Micromonosporales 201174|Actinobacteria N Flagellar assembly protein FliH fliH - - ko:K02411 ko02040,map02040 - - - ko00000,ko00001,ko02035,ko02044 3.A.6.2 - - FliH k59_78320_1 926561.KB900617_gene1867 1.17e-14 79.3 COG4775@1|root,COG4775@2|Bacteria,1UMDS@1239|Firmicutes,24F0X@186801|Clostridia,3WAA6@53433|Halanaerobiales 186801|Clostridia M PFAM Surface antigen variable number repeat - - - ko:K07277 - - - - ko00000,ko02000,ko03029 1.B.33 - - Bac_surface_Ag,POTRA k59_1602707_1 983544.Lacal_1177 2.69e-85 263.0 COG0719@1|root,COG0719@2|Bacteria,4NFPG@976|Bacteroidetes,1HXNA@117743|Flavobacteriia 976|Bacteroidetes O assembly protein, SufD sufD - - ko:K09015 - - - - ko00000 - - - UPF0051 k59_1377229_1 1453501.JELR01000001_gene3240 7.31e-24 99.8 28MBM@1|root,2ZAQ2@2|Bacteria,1R5V6@1224|Proteobacteria,1S0K0@1236|Gammaproteobacteria,4662R@72275|Alteromonadaceae 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_1377229_2 876044.IMCC3088_2049 1.12e-06 54.7 COG0457@1|root,COG0457@2|Bacteria,1R1PG@1224|Proteobacteria,1T575@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Tetratricopeptide repeat - - - - - - - - - - - - - k59_133892_1 1348657.M622_10065 1.84e-18 85.1 COG1566@1|root,COG1566@2|Bacteria,1MU7I@1224|Proteobacteria,2VHA2@28216|Betaproteobacteria,2KUUB@206389|Rhodocyclales 206389|Rhodocyclales V Biotin-lipoyl like - - - ko:K03543 - M00701 - - ko00000,ko00002,ko02000 8.A.1.1 - - HlyD_3 k59_133892_2 1415756.JQMY01000001_gene3527 1.94e-06 50.8 COG1846@1|root,COG1846@2|Bacteria,1RJPG@1224|Proteobacteria,2TUJP@28211|Alphaproteobacteria,2PEHT@252301|Oceanicola 28211|Alphaproteobacteria K helix_turn_helix multiple antibiotic resistance protein MA20_28880 - - - - - - - - - - - MarR,MarR_2 k59_1150335_1 316407.85676372 1.54e-52 179.0 COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,1RMQQ@1236|Gammaproteobacteria,3XM7M@561|Escherichia 1236|Gammaproteobacteria H acetolactate synthase ilvB GO:0003674,GO:0003824,GO:0003984,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005948,GO:0006082,GO:0006520,GO:0006549,GO:0006573,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009097,GO:0009099,GO:0009987,GO:0016053,GO:0016740,GO:0016744,GO:0019752,GO:0032991,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494,GO:1990234 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - iSDY_1059.SDY_4155 TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_1150335_2 316407.85676373 2.89e-64 196.0 COG0440@1|root,COG0440@2|Bacteria,1N065@1224|Proteobacteria,1S73I@1236|Gammaproteobacteria,3XPW8@561|Escherichia 1236|Gammaproteobacteria E acetolactate synthase ilvN GO:0003674,GO:0003824,GO:0003984,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005948,GO:0006082,GO:0006520,GO:0006549,GO:0006573,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009097,GO:0009099,GO:0009987,GO:0016053,GO:0016740,GO:0016744,GO:0019752,GO:0032991,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494,GO:1990234 2.2.1.6 ko:K01653 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - iAF1260.b3670,iAPECO1_1312.APECO1_2782,iB21_1397.B21_03496,iBWG_1329.BWG_3361,iE2348C_1286.E2348C_3985,iEC042_1314.EC042_4025,iECABU_c1320.ECABU_c41570,iECBD_1354.ECBD_0033,iECB_1328.ECB_03554,iECDH10B_1368.ECDH10B_3853,iECDH1ME8569_1439.ECDH1ME8569_3555,iECD_1391.ECD_03554,iECED1_1282.ECED1_4366,iECH74115_1262.ECH74115_5103,iECIAI1_1343.ECIAI1_3846,iECIAI39_1322.ECIAI39_4272,iECNA114_1301.ECNA114_3825,iECO111_1330.ECO111_4494,iECO26_1355.ECO26_4913,iECOK1_1307.ECOK1_4123,iECP_1309.ECP_3877,iECS88_1305.ECS88_4095,iECSE_1348.ECSE_3954,iECSF_1327.ECSF_3518,iECSP_1301.ECSP_4721,iECUMN_1333.ECUMN_4201,iECW_1372.ECW_m3968,iECs_1301.ECs4611,iEKO11_1354.EKO11_0033,iETEC_1333.ETEC_3964,iEcDH1_1363.EcDH1_0033,iEcE24377_1341.EcE24377A_4179,iEcHS_1320.EcHS_A3883,iEcSMS35_1347.EcSMS35_4037,iEcolC_1368.EcolC_0029,iG2583_1286.G2583_4464,iJO1366.b3670,iJR904.b3670,iLF82_1304.LF82_1110,iNRG857_1313.NRG857_18305,iPC815.YPO2294,iSFV_1184.SFV_3839,iSF_1195.SF3791,iSFxv_1172.SFxv_4123,iSSON_1240.SSON_3624,iS_1188.S3977,iUMN146_1321.UM146_18560,iUMNK88_1353.UMNK88_4479,iUTI89_1310.UTI89_C4226,iWFL_1372.ECW_m3968,iY75_1357.Y75_RS18770,iYL1228.KPN_04073,iZ_1308.Z5164,ic_1306.c4595 ACT,ACT_5 k59_1659484_1 143224.JQMD01000002_gene1435 2.97e-34 128.0 COG2755@1|root,COG2755@2|Bacteria,4NI37@976|Bacteroidetes,1HXM7@117743|Flavobacteriia 976|Bacteroidetes E lipolytic protein G-D-S-L family - - - - - - - - - - - - - k59_1262880_1 436308.Nmar_0503 1.17e-41 151.0 arCOG12815@1|root,arCOG12815@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_1320121_1 1044.EH31_00315 3.7e-14 76.6 COG4719@1|root,COG4719@2|Bacteria,1R87U@1224|Proteobacteria,2U4JA@28211|Alphaproteobacteria,2K3HI@204457|Sphingomonadales 204457|Sphingomonadales S TIGRFAM conserved repeat domain - - - - - - - - - - - - DUF11 k59_1150336_1 234267.Acid_1271 1.72e-17 84.3 COG2885@1|root,COG2885@2|Bacteria,3Y2WJ@57723|Acidobacteria 57723|Acidobacteria M Belongs to the ompA family - - - - - - - - - - - - OmpA k59_1602714_1 247633.GP2143_08905 4.6e-65 222.0 COG1472@1|root,COG1472@2|Bacteria,1MVIV@1224|Proteobacteria,1RMA0@1236|Gammaproteobacteria,1J9QE@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria G Fibronectin type III-like domain bglS - 3.2.1.21 ko:K05349 ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110 - R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040 RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248 ko00000,ko00001,ko01000 - GH3 - Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C k59_585516_1 702113.PP1Y_AT33485 1.14e-59 193.0 COG0330@1|root,COG0330@2|Bacteria,1MV7R@1224|Proteobacteria,2TRP4@28211|Alphaproteobacteria,2K1HR@204457|Sphingomonadales 204457|Sphingomonadales O HflC and HflK could regulate a protease hflC - - ko:K04087 - M00742 - - ko00000,ko00002,ko01000 - - - Band_7 k59_641814_1 1123023.JIAI01000001_gene7727 5.08e-63 233.0 COG4770@1|root,COG4799@1|root,COG4770@2|Bacteria,COG4799@2|Bacteria,2GIZP@201174|Actinobacteria,4DZJ9@85010|Pseudonocardiales 201174|Actinobacteria I Acetyl propionyl-CoA carboxylase, alpha subunit - - - - - - - - - - - - ACC_central,Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2,Carboxyl_trans k59_698686_1 269797.Mbar_A1660 2.15e-83 264.0 COG5476@1|root,arCOG09072@2157|Archaea,2XYJG@28890|Euryarchaeota 28890|Euryarchaeota S MlrC C-terminus - - - - - - - - - - - - DUF1485,MlrC_C k59_585519_1 1198232.CYCME_0703 1.56e-78 245.0 COG0115@1|root,COG0115@2|Bacteria,1MVAT@1224|Proteobacteria,1RPU0@1236|Gammaproteobacteria,460D3@72273|Thiotrichales 72273|Thiotrichales EH Acts on the D-isomers of alanine, leucine, aspartate, glutamate, aminobutyrate, norvaline and asparagine. The enzyme transfers an amino group from a substrate D-amino acid to the pyridoxal phosphate cofactor to form pyridoxamine and an alpha- keto acid in the first half-reaction - - 2.6.1.21 ko:K00824 ko00310,ko00330,ko00360,ko00472,ko00473,ko01100,map00310,map00330,map00360,map00472,map00473,map01100 - R01148,R01582,R02459,R02851,R02924,R05053 RC00006,RC00008,RC00025 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_4 k59_415945_1 436308.Nmar_0214 3.27e-48 166.0 COG0044@1|root,arCOG00689@2157|Archaea,41S8A@651137|Thaumarchaeota 651137|Thaumarchaeota F Amidohydrolase family - - 3.5.2.2 ko:K01464 ko00240,ko00410,ko00770,ko00983,ko01100,map00240,map00410,map00770,map00983,map01100 M00046 R02269,R03055,R08227 RC00632,RC00680 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Amidohydro_1 k59_754690_1 1174528.JH992893_gene5704 6.52e-32 129.0 COG1861@1|root,COG1861@2|Bacteria,1G3T7@1117|Cyanobacteria 1117|Cyanobacteria L Transposase DDE domain group 1 - - - - - - - - - - - - DDE_Tnp_1_4 k59_641821_1 243233.MCA3015 3.54e-78 245.0 COG2133@1|root,COG2133@2|Bacteria,1MVK5@1224|Proteobacteria,1RPE8@1236|Gammaproteobacteria,1XDW4@135618|Methylococcales 135618|Methylococcales G Glucose / Sorbosone dehydrogenase - - - - - - - - - - - - GSDH k59_1432495_1 59196.RICGR_1086 3.69e-24 96.3 COG0250@1|root,COG0250@2|Bacteria,1MU14@1224|Proteobacteria,1RMW0@1236|Gammaproteobacteria,1JCZJ@118969|Legionellales 118969|Legionellales K Participates in transcription elongation, termination and antitermination nusG - - ko:K02601 - - - - ko00000,ko03009,ko03021 - - - KOW,NusG k59_1432495_2 999541.bgla_1g02810 2.24e-51 164.0 COG0080@1|root,COG0080@2|Bacteria,1RA2M@1224|Proteobacteria,2VPZW@28216|Betaproteobacteria,1K762@119060|Burkholderiaceae 28216|Betaproteobacteria J Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors rplK - - ko:K02867 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L11,Ribosomal_L11_N k59_190426_1 316407.1736843 1.64e-59 192.0 COG4174@1|root,COG4174@2|Bacteria,1MVKE@1224|Proteobacteria,1RMH8@1236|Gammaproteobacteria,3XNSP@561|Escherichia 1236|Gammaproteobacteria P ABC transporter permease yejB GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006857,GO:0008150,GO:0015833,GO:0015893,GO:0016020,GO:0022857,GO:0035672,GO:0042221,GO:0042493,GO:0042884,GO:0042886,GO:0042891,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944 - ko:K13894 ko02010,map02010 M00349 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5.21,3.A.1.5.24 - - BPD_transp_1 k59_190426_2 316407.1736844 1.44e-51 171.0 COG4239@1|root,COG4239@2|Bacteria,1MUM5@1224|Proteobacteria,1RNUH@1236|Gammaproteobacteria,3XM4C@561|Escherichia 1236|Gammaproteobacteria P ABC transporter permease protein yejE GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006857,GO:0008150,GO:0015833,GO:0015893,GO:0016020,GO:0035672,GO:0042221,GO:0042493,GO:0042884,GO:0042886,GO:0042891,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944 - ko:K13895 ko02010,map02010 M00349 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5.21,3.A.1.5.24 - - BPD_transp_1,OppC_N k59_473056_1 1086011.HJ01_00714 3.95e-25 108.0 COG2133@1|root,COG2133@2|Bacteria,4NEZC@976|Bacteroidetes,1HXFV@117743|Flavobacteriia,2NTSA@237|Flavobacterium 976|Bacteroidetes G Glucose Sorbosone dehydrogenase gdhB - - ko:K21430 - - - - ko00000,ko01000 - - - GSDH k59_1716761_1 1545915.JROG01000008_gene3400 1.61e-29 124.0 COG1629@1|root,COG4771@2|Bacteria,1N6JG@1224|Proteobacteria,2TSK9@28211|Alphaproteobacteria,2K0T9@204457|Sphingomonadales 204457|Sphingomonadales P Carboxypeptidase regulatory-like domain - - - - - - - - - - - - CarboxypepD_reg,Plug,TonB_dep_Rec k59_1772273_1 215803.DB30_2970 6.89e-15 79.7 COG4191@1|root,COG4191@2|Bacteria,1RGDF@1224|Proteobacteria,42NRI@68525|delta/epsilon subdivisions,2X78P@28221|Deltaproteobacteria,2YXRC@29|Myxococcales 28221|Deltaproteobacteria T Histidine kinase-like ATPases - - - - - - - - - - - - HATPase_c,HisKA,Response_reg k59_310225_2 391615.ABSJ01000004_gene643 1.75e-39 140.0 COG2121@1|root,COG2121@2|Bacteria,1MZID@1224|Proteobacteria,1T7TI@1236|Gammaproteobacteria,1JB79@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Domain of unknown function (DUF374) - - - - - - - - - - - - DUF374 k59_1609296_2 1415778.JQMM01000001_gene718 2.06e-58 189.0 COG1196@1|root,COG1196@2|Bacteria,1NGHR@1224|Proteobacteria,1RQW7@1236|Gammaproteobacteria,1J51Y@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria D Protein of unknown function (DUF3450) - - - - - - - - - - - - DUF3450 k59_1267783_1 395963.Bind_0866 1.77e-61 200.0 COG0385@1|root,COG0385@2|Bacteria,1MUMM@1224|Proteobacteria,2TU7J@28211|Alphaproteobacteria,3N9Y8@45404|Beijerinckiaceae 28211|Alphaproteobacteria S SBF-like CPA transporter family (DUF4137) yfeH GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K14347 - - - - ko00000,ko02000,ko04147 2.A.93.1 - - SBF_like k59_310233_1 330214.NIDE0420 2.06e-74 233.0 COG0079@1|root,COG0079@2|Bacteria,3J0XY@40117|Nitrospirae 40117|Nitrospirae E Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily hisC - 2.6.1.9 ko:K00817 ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230 M00026 R00694,R00734,R03243 RC00006,RC00888 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 k59_310233_2 330214.NIDE0421 1.24e-49 166.0 COG2876@1|root,COG2876@2|Bacteria,3J0A5@40117|Nitrospirae 40117|Nitrospirae E NeuB family - - 2.5.1.54 ko:K03856 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R01826 RC00435 ko00000,ko00001,ko00002,ko01000 - - - DAHP_synth_1 k59_1213371_1 1122137.AQXF01000005_gene1136 9.69e-96 286.0 COG4233@1|root,COG4233@2|Bacteria,1NF38@1224|Proteobacteria,2TVYG@28211|Alphaproteobacteria 28211|Alphaproteobacteria CO to be involved in C-type cytochrome biogenesis - - - - - - - - - - - - DsbC k59_1098711_1 261292.Nit79A3_2580 6.27e-49 165.0 COG0061@1|root,COG0061@2|Bacteria,1MUBC@1224|Proteobacteria,2VIV0@28216|Betaproteobacteria,372GT@32003|Nitrosomonadales 28216|Betaproteobacteria F Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP nadK - 2.7.1.23 ko:K00858 ko00760,ko01100,map00760,map01100 - R00104 RC00002,RC00078 ko00000,ko00001,ko01000 - - - NAD_kinase k59_27582_1 880073.Calab_1817 1.74e-26 111.0 COG1108@1|root,COG1108@2|Bacteria,2NQ6F@2323|unclassified Bacteria 2|Bacteria U ABC 3 transport family znuB - - ko:K02075,ko:K09816 ko02010,map02010 M00242,M00244 - - ko00000,ko00001,ko00002,ko02000 3.A.1.15,3.A.1.15.3,3.A.1.15.5 - - ABC-3 k59_1722049_1 1121396.KB893001_gene3964 2.62e-14 79.3 COG1566@1|root,COG1566@2|Bacteria,1QU7Z@1224|Proteobacteria,43BPM@68525|delta/epsilon subdivisions,2X70W@28221|Deltaproteobacteria,2MPNH@213118|Desulfobacterales 28221|Deltaproteobacteria V Barrel-sandwich domain of CusB or HlyD membrane-fusion ybhG - - ko:K01993 - - - - ko00000 - - - Biotin_lipoyl_2,HlyD_3,HlyD_D23 k59_1775387_1 551275.KB899549_gene870 2.04e-26 104.0 COG0842@1|root,COG0842@2|Bacteria,1RAUW@1224|Proteobacteria,2UBB8@28211|Alphaproteobacteria 28211|Alphaproteobacteria V ABC-2 type transporter - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane k59_1775387_2 1163408.UU9_03338 1.98e-80 253.0 COG1131@1|root,COG1131@2|Bacteria,1RCWC@1224|Proteobacteria,1S27V@1236|Gammaproteobacteria,1X4EE@135614|Xanthomonadales 135614|Xanthomonadales V ABC-type multidrug transport system, ATPase component - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_367148_1 1206731.BAGB01000047_gene5256 0.000413 49.7 COG2909@1|root,COG2909@2|Bacteria,2GM1B@201174|Actinobacteria,4FZRD@85025|Nocardiaceae 201174|Actinobacteria K AAA ATPase domain - - - - - - - - - - - - AAA_16,GerE k59_476717_1 1392838.AWNM01000004_gene1866 7.76e-07 50.8 COG0410@1|root,COG0410@2|Bacteria,1MU4Z@1224|Proteobacteria,2VJUP@28216|Betaproteobacteria,3T6Y0@506|Alcaligenaceae 28216|Betaproteobacteria E ATPases associated with a variety of cellular activities - - - ko:K11963 ko02010,map02010 M00323 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4.4,3.A.1.4.5 - - ABC_tran k59_476717_2 545264.KB898747_gene564 3.71e-79 256.0 COG3604@1|root,COG3604@2|Bacteria,1QTT3@1224|Proteobacteria,1T1G7@1236|Gammaproteobacteria,1WX1Q@135613|Chromatiales 135613|Chromatiales KT Fis Family - - - ko:K02584 ko02020,map02020 - - - ko00000,ko00001,ko03000 - - - GAF,GAF_2,HTH_8,Sigma54_activat k59_1155731_1 1235797.C816_01838 2.47e-17 86.3 COG0322@1|root,COG0322@2|Bacteria,1TP4B@1239|Firmicutes,247TQ@186801|Clostridia,2N6GV@216572|Oscillospiraceae 186801|Clostridia L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision uvrC - - ko:K03703 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - GIY-YIG,HHH_2,HHH_5,UVR,UvrC_HhH_N k59_759052_1 1122137.AQXF01000001_gene3085 1.58e-48 158.0 COG0810@1|root,COG0810@2|Bacteria 2|Bacteria M energy transducer activity tonB - - ko:K03832 - - - - ko00000,ko02000 2.C.1.1 - - CHAT,CarbopepD_reg_2,Haemagg_act,TonB_C k59_759052_2 243277.VC_1140 1.39e-05 46.2 COG1187@1|root,COG1187@2|Bacteria,1R9VV@1224|Proteobacteria,1S1ZX@1236|Gammaproteobacteria,1XUNX@135623|Vibrionales 135623|Vibrionales J Belongs to the pseudouridine synthase RsuA family rluE GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360 5.4.99.20 ko:K06181 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2 k59_84681_1 46429.BV95_02176 5.98e-23 105.0 COG4773@1|root,COG4773@2|Bacteria,1QTXJ@1224|Proteobacteria,2U2G4@28211|Alphaproteobacteria,2KEBD@204457|Sphingomonadales 204457|Sphingomonadales P PFAM TonB-dependent Receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_532182_2 1168059.KB899087_gene1249 2.57e-48 157.0 COG0346@1|root,COG0346@2|Bacteria,1RCYX@1224|Proteobacteria,2U7A8@28211|Alphaproteobacteria,3EZ9N@335928|Xanthobacteraceae 28211|Alphaproteobacteria E Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily gloA GO:0003674,GO:0003824,GO:0004462,GO:0006518,GO:0006575,GO:0006749,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016829,GO:0016846,GO:0034641,GO:0043603,GO:0044237,GO:0051186,GO:0071704,GO:1901564 4.4.1.5 ko:K01759 ko00620,map00620 - R02530 RC00004,RC00740 ko00000,ko00001,ko01000 - - - Glyoxalase k59_1213392_1 87626.PTD2_12814 2.42e-82 254.0 COG0667@1|root,COG0667@2|Bacteria,1MV2Y@1224|Proteobacteria,1RNXH@1236|Gammaproteobacteria,2Q0RZ@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria C oxidoreductases (related to aryl-alcohol dehydrogenases) tas GO:0003674,GO:0003824,GO:0004033,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0007154,GO:0008150,GO:0008152,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0016491,GO:0016614,GO:0016616,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0034198,GO:0042594,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716,GO:0055114,GO:0071496,GO:1990928 - - - - - - - - - - Aldo_ket_red k59_875453_1 1265313.HRUBRA_01647 2.91e-84 254.0 COG0714@1|root,COG0714@2|Bacteria,1MV5I@1224|Proteobacteria,1RQ62@1236|Gammaproteobacteria,1J7IB@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S COG0714 MoxR-like ATPases HA62_21050 - - - - - - - - - - - AAA,AAA_5 k59_875453_2 1265313.HRUBRA_01646 9.01e-111 328.0 COG3825@1|root,COG3825@2|Bacteria,1MUAJ@1224|Proteobacteria,1RMRY@1236|Gammaproteobacteria,1J7JQ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S protein conserved in bacteria IV02_28405 - - ko:K09989 - - - - ko00000 - - - VWA_CoxE k59_591755_1 246197.MXAN_5105 5.08e-63 206.0 COG0548@1|root,COG0548@2|Bacteria,1MU17@1224|Proteobacteria,42N8G@68525|delta/epsilon subdivisions,2WKBC@28221|Deltaproteobacteria 28221|Deltaproteobacteria F Belongs to the acetylglutamate kinase family. ArgB subfamily argB GO:0003674,GO:0003824,GO:0003991,GO:0005488,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016597,GO:0016740,GO:0016772,GO:0016774,GO:0019752,GO:0031406,GO:0034618,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.2.8 ko:K00930 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028 R02649 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase k59_759058_1 237609.PSAKL28_06280 1.84e-74 236.0 COG0773@1|root,COG0773@2|Bacteria,1MUC5@1224|Proteobacteria,1RMMT@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Reutilizes the intact tripeptide L-alanyl-gamma-D- glutamyl-meso-diaminopimelate by linking it to UDP-N- acetylmuramate mpl - 6.3.2.45 ko:K02558 - - - - ko00000,ko01000 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_367167_1 1229909.NSED_00105 2.4e-152 436.0 COG2073@1|root,arCOG00651@2157|Archaea,41S83@651137|Thaumarchaeota 651137|Thaumarchaeota H Cobalamin synthesis G C-terminus - - 3.7.1.12 ko:K02189 ko00860,ko01100,map00860,map01100 - R07772 RC01545,RC02097 ko00000,ko00001,ko01000 - - - CbiG_C,CbiG_N,CbiG_mid k59_140230_1 138119.DSY3417 5.27e-13 74.7 COG3316@1|root,COG3316@2|Bacteria,1VZPC@1239|Firmicutes,251Y5@186801|Clostridia,26125@186807|Peptococcaceae 186801|Clostridia L PFAM transposase IS66 - - - ko:K07484 - - - - ko00000 - - - DDE_Tnp_IS66,DDE_Tnp_IS66_C,LZ_Tnp_IS66,zf-IS66 k59_1664351_1 1005999.GLGR_0045 5.92e-54 192.0 COG4953@1|root,COG4953@2|Bacteria,1MUA9@1224|Proteobacteria,1RMBV@1236|Gammaproteobacteria 1236|Gammaproteobacteria M penicillin-binding protein 1C pbpC - 2.4.1.129 ko:K05367 ko00550,map00550 - - - ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 - BiPBP_C,Transgly,Transpeptidase k59_1722079_1 263358.VAB18032_14510 2.55e-12 66.2 COG0667@1|root,COG0667@2|Bacteria,2GKEP@201174|Actinobacteria,4D972@85008|Micromonosporales 201174|Actinobacteria C aldo keto reductase - - - - - - - - - - - - Aldo_ket_red k59_310264_1 483219.LILAB_01095 9.41e-30 116.0 COG0276@1|root,COG0276@2|Bacteria,1MVR1@1224|Proteobacteria,42M0C@68525|delta/epsilon subdivisions,2WMJ2@28221|Deltaproteobacteria,2YY0V@29|Myxococcales 28221|Deltaproteobacteria H Catalyzes the ferrous insertion into protoporphyrin IX hemH GO:0003674,GO:0003824,GO:0004325,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.99.1.1,4.99.1.9 ko:K01772 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R00310,R11329 RC01012 ko00000,ko00001,ko00002,ko01000 - - - Ferrochelatase k59_310264_2 1476583.DEIPH_ctg008orf0117 1.39e-46 160.0 COG0652@1|root,COG0652@2|Bacteria,1WIFK@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus O PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides - - 5.2.1.8 ko:K01802,ko:K03768 - - - - ko00000,ko01000,ko03110 - - - Pro_isomerase k59_1324594_1 1123054.KB907708_gene2066 4.59e-19 85.9 COG0454@1|root,COG0456@2|Bacteria,1R407@1224|Proteobacteria,1RPJ2@1236|Gammaproteobacteria,1X20E@135613|Chromatiales 135613|Chromatiales K Putative thioesterase (yiiD_Cterm) - - - - - - - - - - - - YiiD_C k59_1324594_2 631362.Thi970DRAFT_04215 9.6e-67 207.0 COG3751@1|root,COG3751@2|Bacteria,1RBXB@1224|Proteobacteria,1RR8W@1236|Gammaproteobacteria,1WWUG@135613|Chromatiales 135613|Chromatiales O 2OG-Fe(II) oxygenase superfamily - - - - - - - - - - - - 2OG-FeII_Oxy_3 k59_1722088_1 194867.ALBQ01000002_gene904 6.6e-41 153.0 COG2211@1|root,COG2211@2|Bacteria,1MVUM@1224|Proteobacteria,2TVI8@28211|Alphaproteobacteria,2K092@204457|Sphingomonadales 204457|Sphingomonadales G COG2211 Na melibiose symporter and related transporters - - - - - - - - - - - - MFS_2 k59_1098747_1 1306406.ASHX01000001_gene1294 1.59e-71 228.0 COG1125@1|root,COG1125@2|Bacteria,2GJHI@201174|Actinobacteria 201174|Actinobacteria E ABC transporter opuCA - - ko:K05847 ko02010,map02010 M00209 - - ko00000,ko00001,ko00002,ko02000 3.A.1.12 - - ABC_tran k59_759070_1 1137281.D778_01665 1.76e-110 332.0 COG2755@1|root,COG2755@2|Bacteria,4NGTK@976|Bacteroidetes,1HY1A@117743|Flavobacteriia 976|Bacteroidetes E G-D-S-L family lipolytic protein - - - - - - - - - - - - Lipase_GDSL k59_476747_1 1209072.ALBT01000025_gene3715 1.21e-15 82.8 COG1025@1|root,COG1025@2|Bacteria,1QTVC@1224|Proteobacteria,1T1IG@1236|Gammaproteobacteria,1FG3K@10|Cellvibrio 1236|Gammaproteobacteria O Middle or third domain of peptidase_M16 ptrA GO:0003674,GO:0003824,GO:0004175,GO:0004222,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0008270,GO:0016787,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043167,GO:0043169,GO:0043170,GO:0044238,GO:0044424,GO:0044464,GO:0046872,GO:0046914,GO:0070011,GO:0071704,GO:0140096,GO:1901564 3.4.24.55 ko:K01407 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M16,Peptidase_M16_C,Peptidase_M16_M k59_1496950_1 1121447.JONL01000003_gene3276 2.18e-62 214.0 COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria,42MFK@68525|delta/epsilon subdivisions,2WKBU@28221|Deltaproteobacteria,2M7XJ@213115|Desulfovibrionales 28221|Deltaproteobacteria E extracellular solute-binding protein, family 5 - - - ko:K02035,ko:K13893 ko02010,ko02024,map02010,map02024 M00239,M00349 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5,3.A.1.5.21,3.A.1.5.24 - - SBP_bac_5 k59_310277_1 158500.BV97_04592 2.52e-15 81.6 COG3292@1|root,COG3292@2|Bacteria,1QMJ4@1224|Proteobacteria,2U2MF@28211|Alphaproteobacteria 28211|Alphaproteobacteria T Two component regulator propeller - - - - - - - - - - - - Tail_P2_I k59_1155767_1 1122137.AQXF01000001_gene3360 1.39e-90 282.0 COG5388@1|root,COG5388@2|Bacteria,1R74W@1224|Proteobacteria,2TUTW@28211|Alphaproteobacteria 28211|Alphaproteobacteria S PAS domain - - - - - - - - - - - - - k59_252503_1 247490.KSU1_C0273 6.62e-64 221.0 COG4447@1|root,COG4447@2|Bacteria 2|Bacteria S cellulose binding - - - - - - - - - - - - Beta_helix,Big_3_2,PSII_BNR,TIG,VCBS k59_1496956_1 153948.NAL212_0165 5.01e-90 278.0 COG0593@1|root,COG0593@2|Bacteria,1MU5H@1224|Proteobacteria,2VHH0@28216|Betaproteobacteria,372M3@32003|Nitrosomonadales 28216|Betaproteobacteria L it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids dnaA - - ko:K02313 ko02020,ko04112,map02020,map04112 - - - ko00000,ko00001,ko03032,ko03036 - - - Bac_DnaA,Bac_DnaA_C,DnaA_N k59_421201_1 314232.SKA53_12593 1.44e-90 273.0 COG0189@1|root,COG0189@2|Bacteria,1MX62@1224|Proteobacteria,2TRUH@28211|Alphaproteobacteria 28211|Alphaproteobacteria HJ Belongs to the RimK family rimK - 6.3.2.32 ko:K05844,ko:K14940 ko00680,ko01120,map00680,map01120 - R09401 RC00064,RC00090 ko00000,ko00001,ko01000,ko03009 - - - RimK,Zn_protease k59_875495_2 1147.D082_17950 3.99e-83 257.0 COG0082@1|root,COG0082@2|Bacteria,1G12S@1117|Cyanobacteria,1H4WC@1142|Synechocystis 1117|Cyanobacteria E Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system aroC GO:0000166,GO:0003674,GO:0003824,GO:0004107,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0010181,GO:0016053,GO:0016829,GO:0016835,GO:0016838,GO:0019438,GO:0019752,GO:0032553,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050662,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 4.2.3.5 ko:K01736 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R01714 RC00586 ko00000,ko00001,ko00002,ko01000 - - iJN678.aroC Chorismate_synt k59_310290_2 1229909.NSED_01620 5.53e-95 283.0 COG1691@1|root,arCOG02465@2157|Archaea,41SCY@651137|Thaumarchaeota 651137|Thaumarchaeota S AIR carboxylase - - - ko:K06898 - - - - ko00000 - - - AIRC k59_140251_1 1038866.KB902775_gene5441 1.89e-18 87.8 COG2084@1|root,COG2084@2|Bacteria,1MUGU@1224|Proteobacteria,2TUUJ@28211|Alphaproteobacteria,3JV1R@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria I NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase - - 1.1.1.60 ko:K00042 ko00630,ko01100,map00630,map01100 - R01745,R01747 RC00099 ko00000,ko00001,ko01000 - - - NAD_binding_11,NAD_binding_2 k59_646399_1 1036674.A28LD_1782 6.55e-11 67.4 COG0596@1|root,COG0596@2|Bacteria,1R6KU@1224|Proteobacteria,1RNTQ@1236|Gammaproteobacteria,2QFU6@267893|Idiomarinaceae 1236|Gammaproteobacteria I TAP-like protein - - - - - - - - - - - - Abhydrolase_1,Abhydrolase_4 k59_1383563_1 1333998.M2A_2034 4.78e-124 364.0 COG1960@1|root,COG1960@2|Bacteria,1MU2V@1224|Proteobacteria,2TSK3@28211|Alphaproteobacteria,4BPRD@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria I Acyl-CoA dehydrogenase, C-terminal domain - - 1.3.8.7 ko:K00249 ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320 M00013,M00036,M00087 R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754 RC00052,RC00068,RC00076,RC00095,RC00148,RC00246 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_252525_1 580332.Slit_0445 1.94e-72 244.0 COG1643@1|root,COG2852@1|root,COG1643@2|Bacteria,COG2852@2|Bacteria,1MUEQ@1224|Proteobacteria,2VI3R@28216|Betaproteobacteria,44VDV@713636|Nitrosomonadales 28216|Betaproteobacteria L Helicase associated domain (HA2) Add an annotation hrpA - 3.6.4.13 ko:K03578 - - - - ko00000,ko01000 - - - DEAD,DUF3418,HA2,Helicase_C,OB_NTP_bind k59_1155796_1 379066.GAU_2073 1.77e-48 164.0 COG0008@1|root,COG0008@2|Bacteria,1ZURR@142182|Gemmatimonadetes 142182|Gemmatimonadetes J tRNA synthetases class I (E and Q), catalytic domain - - - ko:K01894 - - - - ko00000,ko01000,ko01007,ko03016 - - - tRNA-synt_1c k59_591819_1 203122.Sde_1273 1.47e-84 261.0 COG1312@1|root,COG1312@2|Bacteria,1MWYD@1224|Proteobacteria,1RR0Q@1236|Gammaproteobacteria,465TP@72275|Alteromonadaceae 1236|Gammaproteobacteria G Catalyzes the dehydration of D-mannonate uxuA - 4.2.1.8 ko:K01686 ko00040,ko01100,map00040,map01100 M00061 R05606 RC00543 ko00000,ko00001,ko00002,ko01000 - - - UxuA k59_646401_1 264462.Bd0953 2.57e-23 91.3 COG0361@1|root,COG0361@2|Bacteria,1MZFU@1224|Proteobacteria,42WGE@68525|delta/epsilon subdivisions,2MUAS@213481|Bdellovibrionales,2WRF1@28221|Deltaproteobacteria 213481|Bdellovibrionales J One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex infA - - ko:K02518 - - - - ko00000,ko03012 - - - eIF-1a k59_646401_2 1382356.JQMP01000003_gene1507 1.15e-56 192.0 COG1230@1|root,COG1230@2|Bacteria,2G6FI@200795|Chloroflexi,27XHG@189775|Thermomicrobia 189775|Thermomicrobia P Cation efflux family - - - ko:K16264 - - - - ko00000,ko02000 2.A.4.1 - - Cation_efflux k59_252534_1 1131553.JIBI01000007_gene1169 5.65e-40 141.0 COG1136@1|root,COG1136@2|Bacteria,1NCFC@1224|Proteobacteria,2VIQD@28216|Betaproteobacteria,371Q9@32003|Nitrosomonadales 28216|Betaproteobacteria V ABC transporter - - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_928862_2 1117647.M5M_15840 2.95e-19 85.9 2EDDS@1|root,337A2@2|Bacteria,1NAD0@1224|Proteobacteria,1SDWE@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_1498251_1 118166.JH976537_gene1396 2.8e-85 260.0 COG1117@1|root,COG1117@2|Bacteria,1G0P6@1117|Cyanobacteria,1H8Z3@1150|Oscillatoriales 1117|Cyanobacteria P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system pstB - 3.6.3.27 ko:K02036 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.7 - - ABC_tran k59_1554884_1 7176.CPIJ040082-PA 5.23e-47 163.0 COG1005@1|root,KOG4770@2759|Eukaryota,39SC3@33154|Opisthokonta,3BGSE@33208|Metazoa,3D3H4@33213|Bilateria,421VX@6656|Arthropoda,3SP05@50557|Insecta,44XGC@7147|Diptera,45EJH@7148|Nematocera 33208|Metazoa C Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity) ND1 GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0005746,GO:0005747,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006979,GO:0006996,GO:0007005,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0010033,GO:0010257,GO:0014070,GO:0015980,GO:0016020,GO:0016043,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0019866,GO:0022607,GO:0022900,GO:0022904,GO:0030425,GO:0030964,GO:0031090,GO:0031966,GO:0031967,GO:0031975,GO:0032981,GO:0032991,GO:0033108,GO:0033194,GO:0034622,GO:0034641,GO:0036477,GO:0042221,GO:0042493,GO:0042773,GO:0042775,GO:0042995,GO:0043005,GO:0043025,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044281,GO:0044297,GO:0044422,GO:0044424,GO:0044425,GO:0044429,GO:0044444,GO:0044446,GO:0044455,GO:0044463,GO:0044464,GO:0045271,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0050896,GO:0055086,GO:0055114,GO:0065003,GO:0070469,GO:0071704,GO:0071840,GO:0072521,GO:0097447,GO:0097458,GO:0098796,GO:0098798,GO:0098800,GO:0098803,GO:0120025,GO:0120038,GO:1901135,GO:1901360,GO:1901564,GO:1901700,GO:1902494,GO:1990204 1.6.5.3 ko:K03878 ko00190,ko01100,ko04714,ko04723,ko05012,map00190,map01100,map04714,map04723,map05012 M00142 R11945 RC00061 ko00000,ko00001,ko00002,ko01000,ko03029 3.D.1.6 - - NADHdh k59_1610627_1 379066.GAU_2742 2.36e-111 346.0 COG0433@1|root,COG0433@2|Bacteria,1ZUJE@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Domain of unknown function DUF87 - - - - - - - - - - - - DUF87 k59_1610627_2 1120963.KB894500_gene18 2.03e-87 279.0 COG1297@1|root,COG1297@2|Bacteria,1N7SK@1224|Proteobacteria,1RNC8@1236|Gammaproteobacteria 1236|Gammaproteobacteria S oligopeptide transporter oliA GO:0003674,GO:0005215,GO:0005575,GO:0006810,GO:0008150,GO:0016020,GO:0022857,GO:0051179,GO:0051234,GO:0055085 - - - - - - - - - - OPT k59_1776196_1 436308.Nmar_1782 2.53e-73 235.0 COG1746@1|root,arCOG04249@2157|Archaea,41S76@651137|Thaumarchaeota 651137|Thaumarchaeota J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate cca - 2.7.7.72 ko:K07558 - - R09382,R09383,R09384,R09386 RC00078 ko00000,ko01000,ko03016 - - - NTP_transf_2,tRNA_NucTransf2 k59_1498262_1 224324.aq_1916 5e-38 131.0 COG3118@1|root,COG3118@2|Bacteria,2G453@200783|Aquificae 200783|Aquificae O Belongs to the thioredoxin family trxA - - ko:K03671 ko04621,ko05418,map04621,map05418 - - - ko00000,ko00001,ko03110 - - - Thioredoxin k59_1046497_1 927658.AJUM01000043_gene711 6.02e-79 260.0 COG3250@1|root,COG3250@2|Bacteria,4NEWN@976|Bacteroidetes,2FPM1@200643|Bacteroidia,3XKQI@558415|Marinilabiliaceae 976|Bacteroidetes G Domain of unknown function (DUF4982) - - 3.2.1.23 ko:K01190 ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100 - R01105,R01678,R03355,R04783,R06114 RC00049,RC00452 ko00000,ko00001,ko01000 - - - DUF4982,Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N k59_1384812_1 519989.ECTPHS_10281 1.68e-45 156.0 COG2897@1|root,COG2897@2|Bacteria,1MW4B@1224|Proteobacteria,1RSQ3@1236|Gammaproteobacteria,1WYU5@135613|Chromatiales 135613|Chromatiales P PFAM Rhodanese domain protein - - 2.8.1.1,2.8.1.2 ko:K01011 ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122 - R01931,R03105,R03106 RC00214 ko00000,ko00001,ko01000 - - - Rhodanese k59_477690_1 985867.AEWF01000004_gene315 9.62e-142 419.0 COG0173@1|root,COG0173@2|Bacteria,1MUXB@1224|Proteobacteria,2TR9U@28211|Alphaproteobacteria,47EWW@766|Rickettsiales 766|Rickettsiales J Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) aspS - 6.1.1.12 ko:K01876 ko00970,map00970 M00359,M00360 R05577 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - GAD,tRNA-synt_2,tRNA_anti-codon k59_1665343_1 1122621.ATZA01000028_gene2579 2.88e-08 52.0 COG1733@1|root,COG1733@2|Bacteria,4NT53@976|Bacteroidetes,1J0FB@117747|Sphingobacteriia 976|Bacteroidetes K HxlR-like helix-turn-helix - - - - - - - - - - - - HxlR k59_1665343_2 1048983.EL17_21680 1.67e-37 137.0 COG0702@1|root,COG0702@2|Bacteria,4NE40@976|Bacteroidetes,47NXI@768503|Cytophagia 976|Bacteroidetes GM NmrA family - - 1.6.5.2 ko:K19267 ko00130,ko01110,map00130,map01110 - R02964,R03643,R03816 RC00819 ko00000,ko00001,ko01000 - - - NmrA k59_1268696_1 1254432.SCE1572_09975 1.3e-66 206.0 COG1484@1|root,COG1484@2|Bacteria,1MWQX@1224|Proteobacteria,42NG2@68525|delta/epsilon subdivisions,2WK33@28221|Deltaproteobacteria,2YV8H@29|Myxococcales 28221|Deltaproteobacteria L PFAM IstB domain protein ATP-binding protein - - - - - - - - - - - - IstB_IS21 k59_422124_1 153948.NAL212_1700 4.97e-15 80.5 COG2931@1|root,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,2W21A@28216|Betaproteobacteria,3744N@32003|Nitrosomonadales 28216|Betaproteobacteria Q Domain of unknown function (DUF4214) - - - - - - - - - - - - DUF4214,HemolysinCabind k59_1498286_1 436308.Nmar_0822 1.1e-114 340.0 COG0161@1|root,arCOG00917@2157|Archaea,41S7K@651137|Thaumarchaeota 651137|Thaumarchaeota H Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family - - 2.6.1.62 ko:K00833 ko00780,ko01100,map00780,map01100 M00123,M00573,M00577 R03231 RC00006,RC00887 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 k59_1610658_1 1205680.CAKO01000029_gene5143 2.67e-91 281.0 COG1206@1|root,COG1206@2|Bacteria,1MWNQ@1224|Proteobacteria,2TR6M@28211|Alphaproteobacteria,2JQ17@204441|Rhodospirillales 204441|Rhodospirillales J Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs trmFO - 2.1.1.74 ko:K04094 - - - - ko00000,ko01000,ko03016,ko03036 - - - GIDA k59_929748_1 1288826.MSNKSG1_01993 5.63e-59 198.0 COG0260@1|root,COG0260@2|Bacteria,1MXP6@1224|Proteobacteria,1RYKJ@1236|Gammaproteobacteria 1236|Gammaproteobacteria E Belongs to the peptidase M17 family - - 3.4.11.1,3.4.11.5 ko:K01255,ko:K01259 ko00330,ko00480,ko01100,map00330,map00480,map01100 - R00135,R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 - - - Peptidase_M17 k59_1331033_1 296591.Bpro_2800 3.61e-112 338.0 COG0028@1|root,COG0028@2|Bacteria,1MXDW@1224|Proteobacteria,2VHRD@28216|Betaproteobacteria,4ABWV@80864|Comamonadaceae 28216|Betaproteobacteria EH Belongs to the TPP enzyme family oxc - 4.1.1.8 ko:K01577 ko00630,ko01100,map00630,map01100 - R01908 RC00620 ko00000,ko00001,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_824319_1 903818.KI912268_gene1067 1.02e-82 255.0 COG4974@1|root,COG4974@2|Bacteria 2|Bacteria L Belongs to the 'phage' integrase family int - - ko:K04763 - - - - ko00000,ko03036 - - - Phage_int_SAM_4,Phage_integrase k59_1781191_2 307480.IW16_17895 9.63e-19 88.2 COG3823@1|root,COG3823@2|Bacteria,4NF2M@976|Bacteroidetes,1HY29@117743|Flavobacteriia,3ZR2N@59732|Chryseobacterium 976|Bacteroidetes O Glutamine cyclotransferase - - 2.3.2.5 ko:K00683 - - - - ko00000,ko01000 - - - Glu_cyclase_2 k59_261585_1 1521187.JPIM01000066_gene2691 7.85e-28 112.0 COG0498@1|root,COG0498@2|Bacteria,2G66Y@200795|Chloroflexi,375PP@32061|Chloroflexia 32061|Chloroflexia E Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine - - 4.2.3.1 ko:K01733 ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230 M00018 R01466,R05086 RC00017,RC00526 ko00000,ko00001,ko00002,ko01000 - - - PALP k59_261585_2 330214.NIDE4114 4e-127 382.0 COG0440@1|root,COG0460@1|root,COG0440@2|Bacteria,COG0460@2|Bacteria,3J0G1@40117|Nitrospirae 40117|Nitrospirae E Homoserine dehydrogenase - - 1.1.1.3 ko:K00003 ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230 M00017,M00018 R01773,R01775 RC00087 ko00000,ko00001,ko00002,ko01000 - - - ACT,Homoserine_dh,NAD_binding_3 k59_261585_3 555779.Dthio_PD1474 1.33e-120 357.0 COG0436@1|root,COG0436@2|Bacteria,1MWS8@1224|Proteobacteria,42MEF@68525|delta/epsilon subdivisions,2WJ4D@28221|Deltaproteobacteria,2M8VQ@213115|Desulfovibrionales 28221|Deltaproteobacteria E PFAM Aminotransferase class I and II yfdZ - 2.6.1.83 ko:K10206,ko:K14261 ko00300,ko01100,ko01110,ko01130,ko01230,map00300,map01100,map01110,map01130,map01230 M00527 R07613 RC00006,RC01847 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 k59_601170_2 243365.CV_2781 4.59e-18 82.0 COG3791@1|root,COG3791@2|Bacteria,1N023@1224|Proteobacteria,2WFT4@28216|Betaproteobacteria 28216|Betaproteobacteria S Glutathione-dependent formaldehyde-activating enzyme - - - - - - - - - - - - GFA k59_1781196_1 935863.AWZR01000002_gene811 9.89e-20 85.9 COG1595@1|root,COG1595@2|Bacteria,1RINW@1224|Proteobacteria,1T0B3@1236|Gammaproteobacteria,1XCZZ@135614|Xanthomonadales 135614|Xanthomonadales K ECF sigma factor - - - - - - - - - - - - Sigma70_ECF k59_1105532_1 713587.THITH_16310 4.83e-85 279.0 COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,1MV6G@1224|Proteobacteria,1RMYD@1236|Gammaproteobacteria,1WW84@135613|Chromatiales 135613|Chromatiales E Vitamin B12 dependent methionine synthase activation metH - 2.1.1.13 ko:K00548 ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230 M00017 R00946,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 - - - B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans k59_714237_1 1151127.KB906328_gene2357 7.84e-54 183.0 COG0124@1|root,COG0124@2|Bacteria,1MV2K@1224|Proteobacteria,1RPHI@1236|Gammaproteobacteria,1YNT0@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria J Catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA hisS GO:0003674,GO:0003824,GO:0004812,GO:0004821,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006427,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.21 ko:K01892 ko00970,map00970 M00359,M00360 R03655 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iE2348C_1286.E2348C_2797,iECNA114_1301.ECNA114_2592,iECSF_1327.ECSF_2358 HGTP_anticodon,tRNA-synt_His k59_538303_1 555793.WSK_4039 9.29e-119 365.0 COG1629@1|root,COG1629@2|Bacteria,COG4771@2|Bacteria,1R581@1224|Proteobacteria,2U543@28211|Alphaproteobacteria,2K24G@204457|Sphingomonadales 204457|Sphingomonadales P Outer membrane protein beta-barrel family - - - - - - - - - - - - Plug,TonB_dep_Rec k59_884728_1 1301098.PKB_0666 3.35e-50 181.0 COG1429@1|root,COG1429@2|Bacteria,1MU5W@1224|Proteobacteria,1RQED@1236|Gammaproteobacteria 1236|Gammaproteobacteria H COG1429 Cobalamin biosynthesis protein CobN and related Mg-chelatases cobN - 6.6.1.2 ko:K02230 ko00860,ko01100,map00860,map01100 - R05227 RC02000 ko00000,ko00001,ko01000 - - - CobN-Mg_chel k59_427785_1 1137281.D778_01567 1.77e-36 141.0 COG1361@1|root,COG3291@1|root,COG1361@2|Bacteria,COG3291@2|Bacteria,4NM41@976|Bacteroidetes 976|Bacteroidetes V Fibronectin type III - - - - - - - - - - - - CHU_C,Cleaved_Adhesin,MAM,fn3 k59_601199_1 391615.ABSJ01000022_gene341 2.4e-81 263.0 COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,1RNJI@1236|Gammaproteobacteria,1J4RW@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L DNA helicase uvrD GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006289,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009628,GO:0009987,GO:0015616,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017116,GO:0022607,GO:0031297,GO:0032392,GO:0032508,GO:0033554,GO:0034641,GO:0034645,GO:0042623,GO:0042802,GO:0043142,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0045005,GO:0046483,GO:0050896,GO:0051259,GO:0051260,GO:0051276,GO:0051716,GO:0065003,GO:0070035,GO:0070581,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360,GO:1901576 3.6.4.12 ko:K03657 ko03420,ko03430,map03420,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - UvrD-helicase,UvrD_C k59_36698_1 472175.EL18_01547 1.48e-29 114.0 COG0558@1|root,COG0558@2|Bacteria,1MZ8B@1224|Proteobacteria,2U7AP@28211|Alphaproteobacteria,43JVR@69277|Phyllobacteriaceae 28211|Alphaproteobacteria I Belongs to the CDP-alcohol phosphatidyltransferase class-I family MA20_28295 - 2.7.8.41,2.7.8.5 ko:K00995,ko:K08744 ko00564,ko01100,map00564,map01100 - R01801,R02030 RC00002,RC00017,RC02795 ko00000,ko00001,ko01000 - - - CDP-OH_P_transf k59_1052978_1 1121930.AQXG01000008_gene116 2.3e-39 151.0 COG1538@1|root,COG1538@2|Bacteria 2|Bacteria MU efflux transmembrane transporter activity czcC - - ko:K15725 - - - - ko00000,ko02000 1.B.17.2.2 - - OEP k59_319854_1 316407.85676363 3.23e-119 345.0 COG2207@1|root,COG2207@2|Bacteria,1R5IW@1224|Proteobacteria,1S033@1236|Gammaproteobacteria,3XRCD@561|Escherichia 1236|Gammaproteobacteria K sequence-specific DNA binding yidL GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576 - - - - - - - - - - AraC_binding,HTH_18,HTH_AraC k59_261631_1 266265.Bxe_A3936 6.69e-53 178.0 COG0150@1|root,COG0150@2|Bacteria,1MURG@1224|Proteobacteria,2VHJT@28216|Betaproteobacteria,1K2VU@119060|Burkholderiaceae 28216|Betaproteobacteria F Phosphoribosylformylglycinamidine cyclo-ligase purM - 6.3.3.1 ko:K01933 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04208 RC01100 ko00000,ko00001,ko00002,ko01000 - - - AIRS,AIRS_C k59_1616441_1 316407.1799813 8.16e-49 157.0 COG3415@1|root,COG3415@2|Bacteria,1MYR7@1224|Proteobacteria,1S85P@1236|Gammaproteobacteria,3XPIZ@561|Escherichia 1236|Gammaproteobacteria L sequence-specific DNA binding yfeD - - - - - - - - - - - DUF1323 k59_1616441_2 199310.c2934 2.59e-80 238.0 COG3415@1|root,COG3415@2|Bacteria,1RGU5@1224|Proteobacteria,1S6VV@1236|Gammaproteobacteria,3XPQD@561|Escherichia 1236|Gammaproteobacteria L Putative transcription regulator (DUF1323) yfeC - - - - - - - - - - - DUF1323 k59_92534_1 870187.Thini_3634 3.9e-55 194.0 COG0013@1|root,COG0013@2|Bacteria,1MU9A@1224|Proteobacteria,1RMWZ@1236|Gammaproteobacteria,45ZUH@72273|Thiotrichales 72273|Thiotrichales J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain alaS - 6.1.1.7 ko:K01872 ko00970,map00970 M00359,M00360 R03038 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DHHA1,tRNA-synt_2c,tRNA_SAD k59_991230_1 1415778.JQMM01000001_gene590 1.07e-59 196.0 COG1622@1|root,COG1622@2|Bacteria,1MWHZ@1224|Proteobacteria,1RP4H@1236|Gammaproteobacteria,1J5CG@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) coxB - 1.9.3.1 ko:K02275 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.4,3.D.4.6 - - COX2,COX2_TM,Cytochrome_CBB3 k59_991230_2 1122212.AULO01000008_gene1366 3.37e-05 46.2 COG0534@1|root,COG0534@2|Bacteria,1MV6B@1224|Proteobacteria,1RPGF@1236|Gammaproteobacteria,1XI5B@135619|Oceanospirillales 135619|Oceanospirillales V MATE efflux family protein - - - ko:K03327 - - - - ko00000,ko02000 2.A.66.1 - - MatE k59_146598_1 1122611.KB903963_gene4711 1.57e-44 171.0 COG2720@1|root,COG2979@1|root,COG2720@2|Bacteria,COG2979@2|Bacteria,2GISH@201174|Actinobacteria,4EGMA@85012|Streptosporangiales 201174|Actinobacteria V VanW like protein - - - - - - - - - - - - PG_binding_4,VanW k59_36716_1 56780.SYN_00331 1.56e-11 62.0 COG2818@1|root,COG2818@2|Bacteria,1R9X5@1224|Proteobacteria,42QWV@68525|delta/epsilon subdivisions,2WMPT@28221|Deltaproteobacteria 28221|Deltaproteobacteria L PFAM Methyladenine glycosylase tag - 3.2.2.20 ko:K01246 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - Adenine_glyco k59_36716_2 318161.Sden_0646 6.64e-06 53.9 COG0697@1|root,COG0697@2|Bacteria,1MZQM@1224|Proteobacteria,1RW4D@1236|Gammaproteobacteria,2QED6@267890|Shewanellaceae 1236|Gammaproteobacteria EG EamA-like transporter family - - - - - - - - - - - - EamA k59_319861_1 580332.Slit_0815 1.25e-61 204.0 COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,2VMTA@28216|Betaproteobacteria 28216|Betaproteobacteria G Tripartite ATP-independent periplasmic transporter, DctM component - - - - - - - - - - - - DctM,DctQ k59_261636_1 36875.HQ29_02345 3.52e-70 231.0 COG0484@1|root,COG0484@2|Bacteria,4NF41@976|Bacteroidetes,2FPHH@200643|Bacteroidia,22WBJ@171551|Porphyromonadaceae 976|Bacteroidetes O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins dnaJ - - ko:K03686 - - - - ko00000,ko03029,ko03110 - - - DnaJ,DnaJ_C,DnaJ_CXXCXGXG k59_991232_1 377629.TERTU_2431 3.42e-67 214.0 COG1721@1|root,COG1721@2|Bacteria,1Q7RR@1224|Proteobacteria,1RNNP@1236|Gammaproteobacteria,2PNCU@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria S Protein of unknown function DUF58 - - - - - - - - - - - - DUF58 k59_1444093_1 864073.HFRIS_013139 9.57e-18 87.0 COG1017@1|root,COG1018@1|root,COG1017@2|Bacteria,COG1018@2|Bacteria,1MV41@1224|Proteobacteria,2VIIV@28216|Betaproteobacteria,4760R@75682|Oxalobacteraceae 28216|Betaproteobacteria C Belongs to the globin family hmp - 1.14.12.17 ko:K05916,ko:K07006,ko:K21832 ko05132,map05132 - - - ko00000,ko00001,ko01000 - - - FAD_binding_6,Fer2,Globin,NAD_binding_1 k59_1444095_1 228410.NE2391 2.16e-44 159.0 COG1477@1|root,COG2991@1|root,COG1477@2|Bacteria,COG2991@2|Bacteria,1MW6K@1224|Proteobacteria,2VPGP@28216|Betaproteobacteria,371SS@32003|Nitrosomonadales 28216|Betaproteobacteria H Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein apbE - 2.7.1.180 ko:K03734 - - - - ko00000,ko01000 - - - ApbE k59_483211_1 1415778.JQMM01000001_gene710 7.13e-39 137.0 COG1187@1|root,COG1187@2|Bacteria,1MU6M@1224|Proteobacteria,1RQA9@1236|Gammaproteobacteria,1J5U8@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Belongs to the pseudouridine synthase RsuA family rsuA GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360 5.4.99.19 ko:K06183 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2,S4 k59_483211_2 1123487.KB892837_gene3986 1.13e-10 61.2 COG0113@1|root,COG0113@2|Bacteria,1MWMW@1224|Proteobacteria,2VHC6@28216|Betaproteobacteria,2KVZB@206389|Rhodocyclales 206389|Rhodocyclales H Belongs to the ALAD family hemB - 4.2.1.24 ko:K01698 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R00036 RC00918,RC01781 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ALAD k59_1393008_2 1122137.AQXF01000001_gene3079 1.06e-28 107.0 COG0454@1|root,COG0456@2|Bacteria,1N29T@1224|Proteobacteria 1224|Proteobacteria K acetyltransferase - - - - - - - - - - - - Acetyltransf_1,Acetyltransf_10,Acetyltransf_7 k59_1563390_1 118173.KB235914_gene703 4.83e-66 224.0 COG0403@1|root,COG1003@1|root,COG0403@2|Bacteria,COG1003@2|Bacteria,1G1HW@1117|Cyanobacteria,1H6Y0@1150|Oscillatoriales 1117|Cyanobacteria E The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor gcvP - 1.4.4.2 ko:K00281 ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200 M00532 R01221,R03425 RC00022,RC00929,RC02834,RC02880 ko00000,ko00001,ko00002,ko01000 - - - GDC-P k59_1563398_1 981336.F944_02493 3.55e-11 62.0 COG4969@1|root,COG4969@2|Bacteria,1N7EQ@1224|Proteobacteria,1SCES@1236|Gammaproteobacteria 1236|Gammaproteobacteria NU Belongs to the N-Me-Phe pilin family pilA - - ko:K02650,ko:K02655 ko02020,map02020 - - - ko00000,ko00001,ko02035,ko02044 3.A.15.2 - - N_methyl,Pilin k59_538354_1 318424.EU78_16700 7.36e-31 125.0 COG1574@1|root,COG1574@2|Bacteria,2GJVW@201174|Actinobacteria,2370G@1762|Mycobacteriaceae 201174|Actinobacteria S amidohydrolase nfdA_1 - - - - - - - - - - - Amidohydro_3 k59_538354_2 1288079.AUKN01000002_gene5614 0.000211 45.8 COG1309@1|root,COG1309@2|Bacteria,2HG87@201174|Actinobacteria 201174|Actinobacteria K transcriptional regulator - - - - - - - - - - - - TetR_N k59_427830_1 1121937.AUHJ01000014_gene2604 4.23e-60 200.0 COG2239@1|root,COG2239@2|Bacteria,1MW24@1224|Proteobacteria,1RNE4@1236|Gammaproteobacteria,4641S@72275|Alteromonadaceae 1236|Gammaproteobacteria P Acts as a magnesium transporter mgtE - - ko:K06213 - - - - ko00000,ko02000 1.A.26.1 - - CBS,MgtE,MgtE_N k59_1164625_2 1211035.CD30_16660 5.67e-14 72.8 COG1012@1|root,COG1012@2|Bacteria,1TP4S@1239|Firmicutes,4HBS1@91061|Bacilli,3IWI3@400634|Lysinibacillus 91061|Bacilli C 1-pyrroline-5-carboxylate dehydrogenase - - - - - - - - - - - - Aldedh k59_1393029_1 1197477.IA57_07810 2.13e-158 454.0 COG1726@1|root,COG1726@2|Bacteria,4NEDQ@976|Bacteroidetes,1HWV3@117743|Flavobacteriia 976|Bacteroidetes C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol nqrA - 1.6.5.8 ko:K00346 - - - - ko00000,ko01000 - - - NQRA,NQRA_SLBB k59_204021_1 314278.NB231_16708 7.53e-82 263.0 COG1123@1|root,COG4172@2|Bacteria,1MU09@1224|Proteobacteria,1RMEI@1236|Gammaproteobacteria,1WWAN@135613|Chromatiales 135613|Chromatiales P Belongs to the ABC transporter superfamily - - - ko:K02031,ko:K02032 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - ABC_tran,oligo_HPY k59_1275089_1 1123400.KB904749_gene761 8.97e-40 147.0 COG3487@1|root,COG3487@2|Bacteria,1MX5H@1224|Proteobacteria,1RPWE@1236|Gammaproteobacteria 1236|Gammaproteobacteria P Iron-regulated protein icmP - - ko:K07231 - - - - ko00000 - - - Peptidase_M75 k59_602625_1 882378.RBRH_03962 1.33e-64 205.0 COG0652@1|root,COG0652@2|Bacteria,1R9ZQ@1224|Proteobacteria,2VQ6F@28216|Betaproteobacteria,1JZSW@119060|Burkholderiaceae 28216|Betaproteobacteria M PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides ppiA - 5.2.1.8 ko:K03767,ko:K03768 ko01503,ko04217,map01503,map04217 - - - ko00000,ko00001,ko01000,ko03110,ko04147 - - - Pro_isomerase k59_602625_2 391008.Smal_0816 0.000167 43.1 COG2908@1|root,COG2908@2|Bacteria,1N3U7@1224|Proteobacteria,1RP1X@1236|Gammaproteobacteria,1X5K2@135614|Xanthomonadales 135614|Xanthomonadales S Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell lpxH - 3.6.1.54 ko:K03269 ko00540,ko01100,map00540,map01100 M00060 R04549 RC00002 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Metallophos,Metallophos_2 k59_1054094_1 203122.Sde_3586 3.13e-65 202.0 COG3160@1|root,COG3160@2|Bacteria,1RHBB@1224|Proteobacteria,1S420@1236|Gammaproteobacteria,4678R@72275|Alteromonadaceae 1236|Gammaproteobacteria K Belongs to the Rsd AlgQ family rsd GO:0000988,GO:0000989,GO:0003674,GO:0008150,GO:0009889,GO:0010556,GO:0016989,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0140110,GO:1903506,GO:2001141 - ko:K07740 - - - - ko00000 - - - Rsd_AlgQ k59_205316_1 411902.CLOBOL_05972 2.46e-05 49.7 COG3090@1|root,COG3090@2|Bacteria,1UEQT@1239|Firmicutes,25JQH@186801|Clostridia,223A4@1506553|Lachnoclostridium 186801|Clostridia G Tripartite ATP-independent periplasmic transporters, DctQ component - - - - - - - - - - - - DctQ k59_205316_2 580332.Slit_0817 4.11e-15 76.6 COG1638@1|root,COG1638@2|Bacteria,1PN6J@1224|Proteobacteria,2VSNQ@28216|Betaproteobacteria 28216|Betaproteobacteria G Bacterial extracellular solute-binding protein, family 7 - - - - - - - - - - - - DctP k59_886018_1 1229909.NSED_03265 1.06e-65 208.0 COG2084@1|root,arCOG00247@2157|Archaea,41SI2@651137|Thaumarchaeota 651137|Thaumarchaeota I NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase - - 1.1.1.31 ko:K00020 ko00280,ko01100,map00280,map01100 - R05066 RC00099 ko00000,ko00001,ko01000 - - - NAD_binding_11,NAD_binding_2 k59_37960_1 436308.Nmar_0079 1.37e-107 324.0 COG1797@1|root,arCOG00106@2157|Archaea,41SBP@651137|Thaumarchaeota 651137|Thaumarchaeota H Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source cbiA - 6.3.5.11,6.3.5.9 ko:K02224 ko00860,ko01100,ko01120,map00860,map01100,map01120 - R05224,R05815 RC00010,RC01301 ko00000,ko00001,ko01000 - - - CbiA,GATase_3 k59_936842_1 1449076.JOOE01000004_gene475 8.91e-07 49.3 COG0312@1|root,COG0312@2|Bacteria,1MUVW@1224|Proteobacteria,2TSAV@28211|Alphaproteobacteria,2K048@204457|Sphingomonadales 204457|Sphingomonadales S modulator of DNA gyrase pmbA - - ko:K03592 - - - - ko00000,ko01002 - - - PmbA_TldD k59_936842_2 1122137.AQXF01000005_gene1297 6.57e-75 231.0 COG0483@1|root,COG0483@2|Bacteria,1MV4W@1224|Proteobacteria,2TV4R@28211|Alphaproteobacteria 28211|Alphaproteobacteria G Inositol monophosphatase suhB2 - 3.1.3.25 ko:K01092 ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070 M00131 R01185,R01186,R01187 RC00078 ko00000,ko00001,ko00002,ko01000 - - - Inositol_P k59_93675_1 316274.Haur_1458 2.13e-29 126.0 COG0457@1|root,COG2114@1|root,COG3899@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG3899@2|Bacteria,2G699@200795|Chloroflexi,3766E@32061|Chloroflexia 32061|Chloroflexia T Adenylyl- / guanylyl cyclase, catalytic domain - - - - - - - - - - - - AAA_16,Guanylate_cyc,TPR_12 k59_37962_1 99598.Cal7507_0996 1.23e-36 133.0 COG0745@1|root,COG0745@2|Bacteria,1G1EZ@1117|Cyanobacteria,1HJ6B@1161|Nostocales 1117|Cyanobacteria K Two component transcriptional regulator, winged helix family rpaA - - ko:K10697 ko02020,map02020 M00467 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Trans_reg_C k59_37962_2 552531.BIF_01279 2.66e-11 63.9 COG0036@1|root,COG0036@2|Bacteria,2GJZ9@201174|Actinobacteria,4CYX0@85004|Bifidobacteriales 201174|Actinobacteria G Ribulose-phosphate 3-epimerase rpe GO:0003674,GO:0003824,GO:0004750,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009052,GO:0009056,GO:0009117,GO:0009987,GO:0016052,GO:0016853,GO:0016854,GO:0016857,GO:0019321,GO:0019323,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046483,GO:0046496,GO:0046872,GO:0051156,GO:0051186,GO:0055086,GO:0071704,GO:0072524,GO:1901135,GO:1901360,GO:1901564,GO:1901575 5.1.3.1 ko:K01783 ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007 R01529 RC00540 ko00000,ko00001,ko00002,ko01000 - - - Ribul_P_3_epim k59_715641_1 1168065.DOK_12321 1.23e-80 248.0 COG0673@1|root,COG0673@2|Bacteria,1MXUP@1224|Proteobacteria,1RP9K@1236|Gammaproteobacteria,1J9Q9@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S dehydrogenases and related proteins - - 1.1.1.312 ko:K10219 ko00350,ko00362,ko00627,ko01120,ko01220,map00350,map00362,map00627,map01120,map01220 M00533 R04278,R04279,R04418,R04419 RC00251,RC00254 ko00000,ko00001,ko00002,ko01000 - - - GFO_IDH_MocA,GFO_IDH_MocA_C k59_205338_1 702113.PP1Y_AT7201 1.17e-67 223.0 COG0855@1|root,COG0855@2|Bacteria,1MUM3@1224|Proteobacteria,2TRBP@28211|Alphaproteobacteria,2K167@204457|Sphingomonadales 204457|Sphingomonadales P Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) ppk - 2.7.4.1 ko:K00937 ko00190,ko03018,map00190,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - PP_kinase,PP_kinase_C,PP_kinase_N k59_205338_2 702113.PP1Y_AT7189 2.29e-39 143.0 COG0248@1|root,COG0248@2|Bacteria,1MV35@1224|Proteobacteria,2TR1W@28211|Alphaproteobacteria,2JZYK@204457|Sphingomonadales 204457|Sphingomonadales FP exopolyphosphatase - - 3.6.1.11,3.6.1.40 ko:K01524 ko00230,map00230 - R03409 RC00002 ko00000,ko00001,ko01000 - - - Ppx-GppA k59_539291_1 1122599.AUGR01000008_gene2533 3.34e-113 337.0 COG0677@1|root,COG0677@2|Bacteria,1MUC6@1224|Proteobacteria,1RMX0@1236|Gammaproteobacteria,1XI8T@135619|Oceanospirillales 135619|Oceanospirillales M Belongs to the UDP-glucose GDP-mannose dehydrogenase family - - 1.1.1.136 ko:K02474,ko:K13015 ko00520,map00520 - R00421,R06894 RC00291 ko00000,ko00001,ko01000,ko01005 - - - UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N k59_825603_1 1122137.AQXF01000002_gene145 3.58e-147 423.0 COG0372@1|root,COG0372@2|Bacteria,1MUKX@1224|Proteobacteria,2TS63@28211|Alphaproteobacteria 28211|Alphaproteobacteria C Belongs to the citrate synthase family gltA - 2.3.3.1 ko:K01647 ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00740 R00351 RC00004,RC00067 br01601,ko00000,ko00001,ko00002,ko01000 - - - Citrate_synt k59_377528_1 305900.GV64_03150 4.16e-48 164.0 COG1385@1|root,COG1385@2|Bacteria,1MXCU@1224|Proteobacteria,1RPBN@1236|Gammaproteobacteria,1XJ89@135619|Oceanospirillales 135619|Oceanospirillales J Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit rsmE - 2.1.1.193 ko:K09761 - - - - ko00000,ko01000,ko03009 - - - Methyltrans_RNA k59_147585_1 1122137.AQXF01000003_gene1985 1.19e-98 304.0 COG0449@1|root,COG0449@2|Bacteria,1MW4K@1224|Proteobacteria,2TQPM@28211|Alphaproteobacteria 28211|Alphaproteobacteria M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source glmS GO:0003674,GO:0003824,GO:0004360,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006002,GO:0006040,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009987,GO:0016740,GO:0016769,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0036211,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576 2.6.1.16 ko:K00820 ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931 - R00768 RC00010,RC00163,RC02752 ko00000,ko00001,ko01000,ko01002 - - - GATase_6,SIS k59_1730152_1 1122137.AQXF01000002_gene132 3.12e-177 527.0 COG0587@1|root,COG0587@2|Bacteria,1MUIF@1224|Proteobacteria,2TSCN@28211|Alphaproteobacteria 28211|Alphaproteobacteria L DNA polymerase III alpha subunit dnaE GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0050896,GO:0051716,GO:0071496 2.7.7.7 ko:K02337 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon k59_886053_2 436308.Nmar_1651 5.48e-79 243.0 arCOG08794@1|root,arCOG08794@2157|Archaea,41SR7@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_886053_3 436308.Nmar_1273 4.34e-108 322.0 COG3794@1|root,arCOG02926@2157|Archaea 2157|Archaea C PFAM blue (type 1) copper domain protein - - - - - - - - - - - - Copper-bind k59_1782173_1 158500.BV97_02639 8.72e-60 208.0 COG2902@1|root,COG2902@2|Bacteria,1MXNV@1224|Proteobacteria,2TS89@28211|Alphaproteobacteria,2K0WP@204457|Sphingomonadales 204457|Sphingomonadales E glutamate dehydrogenase - - 1.4.1.2 ko:K15371 ko00220,ko00250,ko00430,ko00910,ko01100,map00220,map00250,map00430,map00910,map01100 - R00243 RC00006,RC02799 ko00000,ko00001,ko01000 - - - Bac_GDH k59_766739_1 526225.Gobs_3768 5.78e-22 98.6 COG0526@1|root,COG0526@2|Bacteria,2IET9@201174|Actinobacteria,4EVMS@85013|Frankiales 201174|Actinobacteria CO Evidence 4 Homologs of previously reported genes of - - - - - - - - - - - - - k59_766744_1 706587.Desti_3751 7.16e-56 191.0 COG1032@1|root,COG1032@2|Bacteria,1MY2Y@1224|Proteobacteria,42NG3@68525|delta/epsilon subdivisions,2WJ95@28221|Deltaproteobacteria,2MR6I@213462|Syntrophobacterales 28221|Deltaproteobacteria C Domain of unknown function (DUF4070) - - - - - - - - - - - - B12-binding,DUF4070,Radical_SAM k59_1507214_1 1131269.AQVV01000005_gene386 4.21e-27 108.0 COG0284@1|root,COG0284@2|Bacteria 2|Bacteria F orotidine-5'-phosphate decarboxylase activity pyrF GO:0003674,GO:0003824,GO:0004590,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006206,GO:0006207,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0015949,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019856,GO:0034641,GO:0034654,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046112,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.1.23 ko:K01591 ko00240,ko01100,map00240,map01100 M00051 R00965 RC00409 ko00000,ko00001,ko00002,ko01000 - - iECO103_1326.ECO103_1444,iECSF_1327.ECSF_1264,iSFV_1184.SFV_1294,iSF_1195.SF1285,iSFxv_1172.SFxv_1457,iS_1188.S1368,ic_1306.c1750 OMPdecase k59_1054172_1 1267534.KB906756_gene370 4.4e-43 156.0 COG0443@1|root,COG0443@2|Bacteria,3Y3QN@57723|Acidobacteria,2JIM6@204432|Acidobacteriia 204432|Acidobacteriia O Belongs to the heat shock protein 70 family - - - ko:K04046 - - - - ko00000,ko03110 1.A.33 - - HSP70 k59_93721_1 1122613.ATUP01000001_gene1995 2.31e-53 190.0 COG0019@1|root,COG0527@1|root,COG0019@2|Bacteria,COG0527@2|Bacteria,1MUA6@1224|Proteobacteria,2TQPB@28211|Alphaproteobacteria,43WZD@69657|Hyphomonadaceae 28211|Alphaproteobacteria E Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine lysA - 2.7.2.4,4.1.1.20 ko:K01586,ko:K12526 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00017,M00018,M00525,M00526,M00527 R00451,R00480 RC00002,RC00043,RC00299 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase,Orn_Arg_deC_N,Orn_DAP_Arg_deC k59_1672077_1 1528106.JRJE01000005_gene1311 7.96e-23 93.6 COG3088@1|root,COG3088@2|Bacteria,1MZZ5@1224|Proteobacteria,2U96P@28211|Alphaproteobacteria,2JSQ1@204441|Rhodospirillales 204441|Rhodospirillales P subunit of a heme lyase - - - ko:K02200 - - - - ko00000 - - - CcmH k59_93726_1 1502852.FG94_05013 1.24e-07 50.8 2DBSM@1|root,30K0E@2|Bacteria,1PX6A@1224|Proteobacteria,2WCP9@28216|Betaproteobacteria,477ZV@75682|Oxalobacteraceae 28216|Betaproteobacteria S KTSC domain - - - - - - - - - - - - KTSC k59_93726_2 765420.OSCT_2617 3.43e-23 100.0 COG2008@1|root,COG2008@2|Bacteria,2G5XG@200795|Chloroflexi,374UV@32061|Chloroflexia 32061|Chloroflexia E aromatic amino acid beta-eliminating lyase threonine aldolase - - 4.1.2.48 ko:K01620 ko00260,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map01100,map01110,map01120,map01130,map01230 - R00751,R06171 RC00312,RC00372 ko00000,ko00001,ko01000 - - - Beta_elim_lyase k59_1332126_1 1411685.U062_00270 5.75e-102 303.0 COG1024@1|root,COG1024@2|Bacteria,1MWF6@1224|Proteobacteria,1RZJJ@1236|Gammaproteobacteria 1236|Gammaproteobacteria I Enoyl-CoA hydratase carnithine racemase - - - - - - - - - - - - ECH_1 k59_321294_2 1122137.AQXF01000003_gene1867 5.29e-42 143.0 COG3752@1|root,COG3752@2|Bacteria,1MXCP@1224|Proteobacteria,2TTEP@28211|Alphaproteobacteria 28211|Alphaproteobacteria S membrane - - - - - - - - - - - - DUF1295 k59_1451957_2 1122137.AQXF01000002_gene43 5.47e-47 161.0 COG5265@1|root,COG5265@2|Bacteria,1MWU5@1224|Proteobacteria,2U7S8@28211|Alphaproteobacteria 28211|Alphaproteobacteria O HPr kinase - - - - - - - - - - - - - k59_773246_1 948106.AWZT01000023_gene3946 1.03e-24 107.0 COG1502@1|root,COG1502@2|Bacteria,1MUDJ@1224|Proteobacteria,2VHSI@28216|Betaproteobacteria,1K38N@119060|Burkholderiaceae 28216|Betaproteobacteria I Phospholipase D Transphosphatidylase - - - ko:K06132 ko00564,ko01100,map00564,map01100 - R11062 RC00017 ko00000,ko00001,ko01000 - - - PLDc_2 k59_661684_1 1313172.YM304_06500 1.71e-71 226.0 COG2141@1|root,COG2141@2|Bacteria,2H89R@201174|Actinobacteria 201174|Actinobacteria C Luciferase-like monooxygenase - - - - - - - - - - - - Bac_luciferase k59_269326_1 1088721.NSU_2774 4.31e-118 345.0 COG0130@1|root,COG0130@2|Bacteria,1MV0N@1224|Proteobacteria,2TSJK@28211|Alphaproteobacteria,2K00T@204457|Sphingomonadales 204457|Sphingomonadales J Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs truB - 5.4.99.25 ko:K03177 - - - - ko00000,ko01000,ko03016 - - - TruB_C_2,TruB_N k59_154468_1 159087.Daro_2500 1.21e-12 71.2 2EMVG@1|root,33FHQ@2|Bacteria,1NPM7@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_269335_1 1415754.JQMK01000010_gene1496 4.85e-31 115.0 COG2755@1|root,COG2755@2|Bacteria,1RCXZ@1224|Proteobacteria,1S3QU@1236|Gammaproteobacteria,466ZZ@72275|Alteromonadaceae 1236|Gammaproteobacteria E COG2755 Lysophospholipase L1 and related esterases tesA GO:0003674,GO:0003824,GO:0004620,GO:0004622,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0016289,GO:0016290,GO:0016298,GO:0016787,GO:0016788,GO:0016790,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0042802,GO:0043170,GO:0044238,GO:0044464,GO:0047617,GO:0052689,GO:0071704,GO:0140096,GO:1901564 3.1.1.5 ko:K10804 ko01040,map01040 - - - ko00000,ko00001,ko01000,ko01004 - - iECED1_1282.ECED1_0521,iLF82_1304.LF82_2242,iNRG857_1313.NRG857_02365 Lipase_GDSL_2 k59_269335_2 9365.XP_007531995.1 0.000956 43.1 COG1132@1|root,KOG0055@2759|Eukaryota,38E88@33154|Opisthokonta,3B958@33208|Metazoa,3CVKH@33213|Bilateria,483MS@7711|Chordata,48ZZW@7742|Vertebrata,3J9UA@40674|Mammalia 33208|Metazoa Q ATP-binding cassette, sub-family B (MDR TAP), member 4 ABCB4 GO:0000139,GO:0001101,GO:0003674,GO:0003824,GO:0004012,GO:0005215,GO:0005319,GO:0005548,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005794,GO:0005829,GO:0005856,GO:0005886,GO:0005887,GO:0005911,GO:0005912,GO:0005924,GO:0005925,GO:0006629,GO:0006810,GO:0006811,GO:0006820,GO:0006869,GO:0006996,GO:0008150,GO:0008152,GO:0008525,GO:0009410,GO:0009719,GO:0009725,GO:0009987,GO:0010033,GO:0010876,GO:0012505,GO:0014070,GO:0015399,GO:0015405,GO:0015629,GO:0015711,GO:0015718,GO:0015748,GO:0015849,GO:0015914,GO:0016020,GO:0016021,GO:0016043,GO:0016324,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019216,GO:0019222,GO:0019915,GO:0022804,GO:0022857,GO:0030054,GO:0030055,GO:0031090,GO:0031224,GO:0031226,GO:0031410,GO:0031960,GO:0031974,GO:0031981,GO:0031982,GO:0031984,GO:0032368,GO:0032370,GO:0032371,GO:0032373,GO:0032374,GO:0032376,GO:0032782,GO:0032879,GO:0033036,GO:0033993,GO:0034204,GO:0042221,GO:0042493,GO:0042592,GO:0042623,GO:0042626,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043269,GO:0043270,GO:0043492,GO:0044070,GO:0044238,GO:0044422,GO:0044424,GO:0044425,GO:0044428,GO:0044431,GO:0044433,GO:0044444,GO:0044446,GO:0044459,GO:0044464,GO:0044840,GO:0044841,GO:0045177,GO:0045332,GO:0045472,GO:0046581,GO:0046717,GO:0046903,GO:0046942,GO:0048518,GO:0048522,GO:0048545,GO:0048878,GO:0050789,GO:0050794,GO:0050896,GO:0051049,GO:0051050,GO:0051128,GO:0051130,GO:0051179,GO:0051234,GO:0051235,GO:0051384,GO:0051716,GO:0055085,GO:0055088,GO:0061024,GO:0061091,GO:0061092,GO:0065007,GO:0065008,GO:0070013,GO:0070161,GO:0070887,GO:0071229,GO:0071310,GO:0071396,GO:0071407,GO:0071702,GO:0071704,GO:0071840,GO:0071944,GO:0080090,GO:0090554,GO:0097035,GO:0097708,GO:0098588,GO:0098590,GO:0098791,GO:1901557,GO:1901654,GO:1901700,GO:1901701,GO:1903412,GO:1903413,GO:1903793,GO:1905952,GO:1905954,GO:2001138,GO:2001140 3.6.3.44 ko:K05658,ko:K05659 ko02010,ko04976,ko05206,ko05226,map02010,map04976,map05206,map05226 - - - ko00000,ko00001,ko01000,ko02000,ko04090,ko04147 3.A.1.201 - - ABC_membrane,ABC_tran k59_211615_2 194867.ALBQ01000004_gene3577 6.75e-09 56.6 COG2084@1|root,COG2084@2|Bacteria,1P0X0@1224|Proteobacteria,2U255@28211|Alphaproteobacteria,2K2X3@204457|Sphingomonadales 204457|Sphingomonadales I NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase - - 1.1.1.60 ko:K00042 ko00630,ko01100,map00630,map01100 - R01745,R01747 RC00099 ko00000,ko00001,ko01000 - - - NAD_binding_11,NAD_binding_2 k59_943374_1 316407.85676494 1.44e-133 398.0 COG0243@1|root,COG0243@2|Bacteria,1NR6J@1224|Proteobacteria,1RMVE@1236|Gammaproteobacteria,3XNDI@561|Escherichia 1236|Gammaproteobacteria C This enzyme may serve as a scavenger, allowing the cell to utilize biotin sulfoxide as a biotin source. It reduces a spontaneous oxidation product of biotin, D-biotin D-sulfoxide (BSO or BDS), back to biotin. Also exhibits methionine-(S)-sulfoxide (Met-S-SO) reductase activity, acting specifically on the (S) enantiomer in the free, but not the protein-bound form. It thus plays a role in assimilation of oxidized methionines bisC GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009060,GO:0009061,GO:0009390,GO:0009897,GO:0009986,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016661,GO:0016662,GO:0016667,GO:0016671,GO:0022900,GO:0030151,GO:0030288,GO:0030313,GO:0031224,GO:0031226,GO:0031233,GO:0031237,GO:0031975,GO:0032991,GO:0033744,GO:0033797,GO:0042597,GO:0043167,GO:0043169,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0045333,GO:0046872,GO:0046914,GO:0048037,GO:0050626,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0071944,GO:0098552,GO:0098567,GO:1902494 1.7.2.3,1.8.5.3,1.97.1.9 ko:K07306,ko:K07309,ko:K07310,ko:K07811,ko:K07812,ko:K08351 ko00450,ko00780,ko00920,ko01100,ko02020,map00450,map00780,map00920,map01100,map02020 - R07229,R09501,R10127 RC02420,RC02555,RC03056 ko00000,ko00001,ko01000,ko02000 5.A.3.3,5.A.3.4 - iE2348C_1286.E2348C_1672,iEC042_1314.EC042_1073,iECOK1_1307.ECOK1_3996,iECSE_1348.ECSE_0952,iEcHS_1320.EcHS_A3752,iEcolC_1368.EcolC_0165,iNRG857_1313.NRG857_07945,iNRG857_1313.NRG857_09385,iUTI89_1310.UTI89_C4091 Molybdopterin,Molydop_binding k59_1228187_1 330214.NIDE0584 4.79e-31 124.0 COG0642@1|root,COG0784@1|root,COG2202@1|root,COG0784@2|Bacteria,COG2202@2|Bacteria,COG2205@2|Bacteria,3J0ZF@40117|Nitrospirae 2|Bacteria T Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - - - - - - - - - - CHASE3,CHASE8,GAF,GAF_2,HAMP,HATPase_c,HisKA,Hpt,PAS,PAS_3,PAS_4,PAS_7,PAS_8,PAS_9,Response_reg k59_546409_1 1123290.AUDQ01000013_gene1251 4.47e-34 123.0 COG0346@1|root,COG0346@2|Bacteria,1V6SC@1239|Firmicutes,4HCP5@91061|Bacilli,26F1P@186818|Planococcaceae 91061|Bacilli E Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily mce - 5.1.99.1 ko:K05606 ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200 M00373,M00375,M00376,M00741 R02765,R09979 RC00780,RC02739 ko00000,ko00001,ko00002,ko01000 - - - Glyoxalase_4 k59_546409_2 1227739.Hsw_3677 1.84e-13 69.3 COG1960@1|root,COG1960@2|Bacteria,4NEHA@976|Bacteroidetes,47K4J@768503|Cytophagia 976|Bacteroidetes I acyl-CoA dehydrogenase acdA - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_384069_1 1111728.ATYS01000028_gene2659 3.18e-31 119.0 COG0725@1|root,COG0725@2|Bacteria,1PA2T@1224|Proteobacteria,1RQ5K@1236|Gammaproteobacteria 1236|Gammaproteobacteria P ABC transporter substrate-binding protein - - 5.3.3.7 ko:K02020,ko:K22003 ko00660,ko02010,map00660,map02010 M00189 R02244 RC00668 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.8 - - SBP_bac_11 k59_1451984_1 1463845.JOIG01000006_gene1011 1.7e-95 328.0 COG1020@1|root,COG1028@1|root,COG3321@1|root,COG1020@2|Bacteria,COG1028@2|Bacteria,COG3321@2|Bacteria,2GISR@201174|Actinobacteria 201174|Actinobacteria Q Non-ribosomal peptide synthetase modules and related proteins - - - ko:K15395 - - - - ko00000,ko01008 - - - AMP-binding,AMP-binding_C,Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,PS-DH,Thioesterase,ketoacyl-synt k59_99928_1 32057.KB217483_gene9876 2.49e-11 73.6 COG0286@1|root,COG0286@2|Bacteria,1GQ52@1117|Cyanobacteria 1117|Cyanobacteria V site-specific DNA-methyltransferase (adenine-specific) activity - - - - - - - - - - - - MTS k59_1338477_1 997346.HMPREF9374_0704 8.55e-10 63.2 COG0195@1|root,COG0195@2|Bacteria,1TPB3@1239|Firmicutes,4HA7F@91061|Bacilli,27B5M@186824|Thermoactinomycetaceae 91061|Bacilli K NusA-like KH domain nusA GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0043244,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:1903506,GO:2000112,GO:2001141 - ko:K02600 - - - - ko00000,ko03009,ko03021 - - - KH_5,NusA_N,S1 k59_327496_1 290397.Adeh_1905 1.86e-32 120.0 COG1403@1|root,COG1403@2|Bacteria,1MWEQ@1224|Proteobacteria,437B2@68525|delta/epsilon subdivisions,2X2FR@28221|Deltaproteobacteria,2Z0QW@29|Myxococcales 28221|Deltaproteobacteria L HNH endonuclease - - - - - - - - - - - - HNH_5 k59_435272_1 436308.Nmar_0777 8.57e-46 148.0 COG1828@1|root,arCOG04462@2157|Archaea,41STY@651137|Thaumarchaeota 651137|Thaumarchaeota F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL purS - 6.3.5.3 ko:K01952 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04463 RC00010,RC01160 ko00000,ko00001,ko00002,ko01000 - - - PurS k59_435272_2 436308.Nmar_0778 9.94e-16 72.4 COG0517@1|root,arCOG00606@2157|Archaea,41SRY@651137|Thaumarchaeota 651137|Thaumarchaeota S Domain in cystathionine beta-synthase and other proteins. - - - - - - - - - - - - CBS k59_384097_1 1249627.D779_3083 1.17e-44 155.0 COG1475@1|root,COG1475@2|Bacteria,1MW2E@1224|Proteobacteria,1RN65@1236|Gammaproteobacteria,1WWNZ@135613|Chromatiales 135613|Chromatiales K Belongs to the ParB family - - - ko:K03497 - - - - ko00000,ko03000,ko03036,ko04812 - - - ParBc k59_327507_1 686340.Metal_0843 2.14e-12 68.6 COG0405@1|root,COG0405@2|Bacteria,1MUV6@1224|Proteobacteria,1RMIT@1236|Gammaproteobacteria,1XENK@135618|Methylococcales 135618|Methylococcales M Gamma-glutamyltranspeptidase - - 2.3.2.2,3.4.19.13 ko:K00681 ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100 - R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935 RC00064,RC00090,RC00096 ko00000,ko00001,ko01000,ko01002 - - - G_glu_transpept k59_327507_2 1121924.ATWH01000014_gene3376 6.39e-73 231.0 COG0473@1|root,COG0473@2|Bacteria,2GK44@201174|Actinobacteria,4FR5I@85023|Microbacteriaceae 201174|Actinobacteria CE Isocitrate/isopropylmalate dehydrogenase - - 1.1.1.83,1.1.1.93,4.1.1.73 ko:K07246 ko00630,ko00650,map00630,map00650 - R00215,R01751,R02545,R06180 RC00084,RC00105,RC00594 ko00000,ko00001,ko01000 - - - Iso_dh k59_1338493_1 1137281.D778_01916 7.7e-154 456.0 COG5009@1|root,COG5009@2|Bacteria,4NECJ@976|Bacteroidetes,1HXWX@117743|Flavobacteriia 976|Bacteroidetes M penicillin-binding protein mrcA - 2.4.1.129,3.4.16.4 ko:K05366 ko00550,ko01100,ko01501,map00550,map01100,map01501 - - - ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 - Transgly,Transpeptidase k59_1228221_1 1089552.KI911559_gene1680 4.13e-49 169.0 COG1575@1|root,COG1575@2|Bacteria,1MXQQ@1224|Proteobacteria,2UAN7@28211|Alphaproteobacteria,2JSRK@204441|Rhodospirillales 204441|Rhodospirillales H UbiA prenyltransferase family - - 2.5.1.74 ko:K02548 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116 R05617,R06858,R10757 RC02935,RC02936,RC03264 ko00000,ko00001,ko00002,ko01000,ko01006 - - - UbiA k59_327515_2 436308.Nmar_0197 6.99e-63 194.0 arCOG08684@1|root,arCOG08684@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_1623733_1 436308.Nmar_0888 5.04e-113 337.0 COG1199@1|root,arCOG00770@2157|Archaea,41T2V@651137|Thaumarchaeota 651137|Thaumarchaeota K HELICc2 - - - - - - - - - - - - Helicase_C_2 k59_722570_1 1282356.H045_16925 4.7e-10 57.8 COG2914@1|root,COG2914@2|Bacteria,1MZCH@1224|Proteobacteria,1SCHG@1236|Gammaproteobacteria,1YQTC@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria S Belongs to the UPF0125 (RnfH) family rnfH - - ko:K09801 - - - - ko00000 - - - Ub-RnfH k59_1679674_1 305900.GV64_02040 2.11e-205 598.0 COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,1RNBG@1236|Gammaproteobacteria,1XI69@135619|Oceanospirillales 135619|Oceanospirillales L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity polA - 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1 k59_944416_1 1122137.AQXF01000002_gene528 1.31e-78 248.0 COG1233@1|root,COG1233@2|Bacteria,1MV2R@1224|Proteobacteria,2TSR0@28211|Alphaproteobacteria 28211|Alphaproteobacteria Q Phytoene dehydrogenase MA20_01895 - - - - - - - - - - - Amino_oxidase k59_944416_2 1122137.AQXF01000002_gene527 5.31e-22 87.8 COG1366@1|root,COG1366@2|Bacteria,1NGGT@1224|Proteobacteria,2UHDV@28211|Alphaproteobacteria 28211|Alphaproteobacteria T COG1366 Anti-anti-sigma regulatory factor (antagonist of anti-sigma factor) - - - ko:K20978 ko02020,ko02025,map02020,map02025 - - - ko00000,ko00001 - - - STAS,STAS_2 k59_1173062_1 1007104.SUS17_1223 1.92e-52 174.0 COG0583@1|root,COG0583@2|Bacteria,1MWVB@1224|Proteobacteria,2TTFG@28211|Alphaproteobacteria,2KCRN@204457|Sphingomonadales 204457|Sphingomonadales K LysR substrate binding domain - - - - - - - - - - - - HTH_1,LysR_substrate k59_1514650_1 717773.Thicy_1308 3.75e-40 141.0 COG0078@1|root,COG0078@2|Bacteria,1MUFM@1224|Proteobacteria,1RQ59@1236|Gammaproteobacteria,460CS@72273|Thiotrichales 72273|Thiotrichales E Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline argF - 2.1.3.3 ko:K00611 ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230 M00029,M00844 R01398 RC00096 ko00000,ko00001,ko00002,ko01000 - - - OTCace,OTCace_N k59_1624660_1 378806.STAUR_3369 5.35e-24 103.0 COG3487@1|root,COG3487@2|Bacteria,1R374@1224|Proteobacteria,42W8V@68525|delta/epsilon subdivisions,2WRMD@28221|Deltaproteobacteria,2YVIW@29|Myxococcales 28221|Deltaproteobacteria P Imelysin - - - - - - - - - - - - Peptidase_M75 k59_547279_1 557598.LHK_02930 8.43e-42 155.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2VHFI@28216|Betaproteobacteria,2KQH5@206351|Neisseriales 206351|Neisseriales V ORF located using Glimmer GeneMark Blastx COG0841 TC acrD - - ko:K03296,ko:K18138 ko01501,ko01503,map01501,map01503 M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000 2.A.6.2 - - ACR_tran k59_547279_2 698761.RTCIAT899_CH17535 2.03e-05 47.4 COG0845@1|root,COG0845@2|Bacteria,1MU78@1224|Proteobacteria,2TSW4@28211|Alphaproteobacteria,4B8T9@82115|Rhizobiaceae 28211|Alphaproteobacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family acrE - - ko:K03585 ko01501,ko01503,map01501,map01503 M00646,M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000,ko03036 2.A.6.2,8.A.1.6 - - HlyD,HlyD_D23 k59_328384_1 1096930.L284_20285 5.77e-68 209.0 COG1610@1|root,COG1610@2|Bacteria,1RGZS@1224|Proteobacteria,2U7DJ@28211|Alphaproteobacteria,2K3W5@204457|Sphingomonadales 204457|Sphingomonadales S Yqey-like protein - - - ko:K09117 - - - - ko00000 - - - YqeY k59_1283013_1 1122939.ATUD01000007_gene1923 1.9e-31 122.0 COG1703@1|root,COG1703@2|Bacteria,2GME8@201174|Actinobacteria,4CP5X@84995|Rubrobacteria 84995|Rubrobacteria E ArgK protein - - - ko:K07588 - - - - ko00000,ko01000 - - - ArgK k59_1402119_1 400682.PAC_15710332 1.14e-29 117.0 COG1132@1|root,KOG0055@2759|Eukaryota,39YRK@33154|Opisthokonta,3BN4Z@33208|Metazoa 33208|Metazoa Q atp-binding protein - - - - - - - - - - - - ABC_tran,oligo_HPY k59_1402119_2 1038859.AXAU01000026_gene2328 2.63e-37 135.0 COG0444@1|root,COG0444@2|Bacteria,1R4KB@1224|Proteobacteria,2TR0J@28211|Alphaproteobacteria,3JRF7@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria EP Oligopeptide/dipeptide transporter, C-terminal region - - - ko:K15583 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00439 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 - - ABC_tran,oligo_HPY k59_1789600_1 395495.Lcho_3398 6.17e-99 295.0 COG0031@1|root,COG0031@2|Bacteria,1MUBE@1224|Proteobacteria,2VJI3@28216|Betaproteobacteria,1KJNM@119065|unclassified Burkholderiales 28216|Betaproteobacteria E Belongs to the cysteine synthase cystathionine beta- synthase family cysK - 2.5.1.47 ko:K01738 ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230 M00021 R00897,R03601,R04859 RC00020,RC02814,RC02821 ko00000,ko00001,ko00002,ko01000 - - - PALP k59_436184_1 1122137.AQXF01000007_gene3547 3.93e-121 357.0 COG0621@1|root,COG0621@2|Bacteria,1MUCS@1224|Proteobacteria,2TRYD@28211|Alphaproteobacteria 28211|Alphaproteobacteria J MiaB-like tRNA modifying enzyme mtaB GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016782,GO:0034470,GO:0034641,GO:0034660,GO:0035596,GO:0035598,GO:0035600,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0050497,GO:0071704,GO:0090304,GO:1901360 2.8.4.5 ko:K18707 - - R10649 RC00003,RC03221 ko00000,ko01000,ko03016 - - - Radical_SAM,UPF0004 k59_610058_1 1188256.BASI01000002_gene3654 8.66e-87 270.0 COG1012@1|root,COG1012@2|Bacteria,1MUHV@1224|Proteobacteria,2TSMD@28211|Alphaproteobacteria,3FCHF@34008|Rhodovulum 28211|Alphaproteobacteria C Aldehyde dehydrogenase family mmsA GO:0003674,GO:0005488,GO:0005507,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0006950,GO:0006979,GO:0008150,GO:0043167,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0050896 1.2.1.18,1.2.1.27 ko:K00140 ko00280,ko00410,ko00562,ko00640,ko01100,ko01200,map00280,map00410,map00562,map00640,map01100,map01200 M00013 R00705,R00706,R00922,R00935 RC00004,RC02723,RC02817 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_832959_1 1095769.CAHF01000022_gene40 4.58e-58 187.0 COG5424@1|root,COG5424@2|Bacteria,1QVK0@1224|Proteobacteria 1224|Proteobacteria H Iron-containing redox enzyme - - - - - - - - - - - - Haem_oxygenas_2 k59_1173074_1 1157490.EL26_08815 8.44e-48 160.0 COG0528@1|root,COG0528@2|Bacteria,1TPXN@1239|Firmicutes,4H9UB@91061|Bacilli,278X5@186823|Alicyclobacillaceae 91061|Bacilli F Catalyzes the reversible phosphorylation of UMP to UDP - - 2.7.4.22 ko:K09903 ko00240,ko01100,map00240,map01100 - R00158 RC00002 ko00000,ko00001,ko01000 - - - AA_kinase k59_1173074_2 1123371.ATXH01000010_gene753 3.08e-11 63.2 COG1559@1|root,COG1559@2|Bacteria,2GHNN@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria S Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation mltG - - ko:K07082 - - - - ko00000 - - - YceG k59_1789604_1 511145.b0651 7.71e-90 270.0 COG1957@1|root,COG1957@2|Bacteria,1MUIW@1224|Proteobacteria,1RSCY@1236|Gammaproteobacteria,3XN0M@561|Escherichia 1236|Gammaproteobacteria F Hydrolyzes with equal efficiency cytidine or uridine to ribose and cytosine or uracil, respectively rihA GO:0003674,GO:0003824,GO:0005488,GO:0005509,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006152,GO:0006213,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008477,GO:0009056,GO:0009116,GO:0009119,GO:0009164,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019439,GO:0034641,GO:0034655,GO:0034656,GO:0042278,GO:0042454,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0045437,GO:0046131,GO:0046133,GO:0046135,GO:0046483,GO:0046700,GO:0046872,GO:0047405,GO:0050263,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:0072527,GO:0072529,GO:1901135,GO:1901136,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575,GO:1901657,GO:1901658 3.2.2.1 ko:K01239,ko:K01250 ko00230,ko00760,ko01100,map00230,map00760,map01100 - R01245,R01273,R01677,R01770,R02143 RC00033,RC00063,RC00122,RC00318,RC00485 ko00000,ko00001,ko01000 - - iEC55989_1330.EC55989_0645,iECSE_1348.ECSE_0721,iEcE24377_1341.EcE24377A_0679,iSbBS512_1146.SbBS512_E0598 IU_nuc_hydro k59_1789604_2 316407.85674731 3.26e-15 73.9 COG0443@1|root,COG0443@2|Bacteria,1MUR1@1224|Proteobacteria,1RR7P@1236|Gammaproteobacteria,3XM93@561|Escherichia 1236|Gammaproteobacteria O heat shock protein 70 hscC GO:0003674,GO:0003824,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111 - ko:K04045 - - - - ko00000,ko03110 1.A.33 - iSFV_1184.SFV_0676 HSP70,MreB_Mbl k59_1679709_2 443598.AUFA01000045_gene836 5.74e-66 203.0 COG1433@1|root,COG1433@2|Bacteria,1RD9P@1224|Proteobacteria,2U9AX@28211|Alphaproteobacteria,3JYAA@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S Dinitrogenase iron-molybdenum cofactor nifX - - ko:K02596 - - - - ko00000 - - - Nitro_FeMo-Co k59_1452875_1 1416759.AYMR01000017_gene2414 2.6e-65 226.0 COG2366@1|root,COG2366@2|Bacteria,2GISQ@201174|Actinobacteria,4FK6Q@85023|Microbacteriaceae 201174|Actinobacteria S Penicillin amidase - - 3.5.1.11 ko:K01434 ko00311,ko01130,map00311,map01130 - R02170 RC00166,RC00328 ko00000,ko00001,ko01000,ko01002 - - - Penicil_amidase k59_1789609_1 7213.XP_004528981.1 2.37e-35 134.0 KOG0253@1|root,KOG0253@2759|Eukaryota,3964S@33154|Opisthokonta,3BYNR@33208|Metazoa,3DET5@33213|Bilateria,427WE@6656|Arthropoda,3SR20@50557|Insecta 33208|Metazoa S Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 k59_1402133_1 935557.ATYB01000008_gene4944 4.84e-39 150.0 COG2202@1|root,COG2203@1|root,COG3290@1|root,COG3920@1|root,COG2202@2|Bacteria,COG2203@2|Bacteria,COG3290@2|Bacteria,COG3920@2|Bacteria,1QQZ6@1224|Proteobacteria,2U3V1@28211|Alphaproteobacteria,4BFN9@82115|Rhizobiaceae 28211|Alphaproteobacteria T HWE histidine kinase exsG - - - - - - - - - - - GAF_2,HWE_HK,PAS_3,PAS_4,PAS_9 k59_100781_1 1144305.PMI02_02239 4.18e-31 119.0 COG1589@1|root,COG1589@2|Bacteria,1MY1Q@1224|Proteobacteria,2TQPU@28211|Alphaproteobacteria,2K1JE@204457|Sphingomonadales 204457|Sphingomonadales D Cell division protein FtsQ ftsQ - - ko:K03589 ko04112,map04112 - - - ko00000,ko00001,ko03036 - - - FtsQ,POTRA_1 k59_100781_2 1088721.NSU_1144 1.67e-75 234.0 COG1181@1|root,COG1181@2|Bacteria,1MUTB@1224|Proteobacteria,2TREC@28211|Alphaproteobacteria,2K0W3@204457|Sphingomonadales 204457|Sphingomonadales M Cell wall formation ddl - 6.3.2.4 ko:K01921 ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502 - R01150 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Dala_Dala_lig_C,Dala_Dala_lig_N k59_1061474_1 436308.Nmar_0248 2.52e-48 162.0 COG0115@1|root,arCOG02297@2157|Archaea,41S5T@651137|Thaumarchaeota 651137|Thaumarchaeota E Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family - - 2.6.1.42 ko:K00826 ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00036,M00119,M00570 R01090,R01214,R02199,R10991 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_4 k59_1061474_2 436308.Nmar_0252 1.66e-97 288.0 COG1056@1|root,arCOG00972@2157|Archaea,41SHQ@651137|Thaumarchaeota 651137|Thaumarchaeota H Nicotinamide-nucleotide adenylyltransferase - - - - - - - - - - - - - k59_1061474_3 436308.Nmar_0253 1.9e-24 98.2 COG1018@1|root,arCOG02200@2157|Archaea,41S72@651137|Thaumarchaeota 651137|Thaumarchaeota C oxidoreductase FAD NAD(P)-binding - - 1.18.1.2,1.19.1.1 ko:K00528 - - R10159 - ko00000,ko01000 - - - FAD_binding_6,NAD_binding_1 k59_547313_2 1122137.AQXF01000003_gene2387 1.02e-101 315.0 COG0457@1|root,COG0457@2|Bacteria,1N0A9@1224|Proteobacteria,2TTMN@28211|Alphaproteobacteria 28211|Alphaproteobacteria S COG0457 FOG TPR repeat - - - - - - - - - - - - TPR_14,TPR_16,TPR_19,TPR_2,TPR_8 k59_270323_1 1121939.L861_10245 1.04e-48 172.0 COG2303@1|root,COG2303@2|Bacteria,1MV19@1224|Proteobacteria,1RMD2@1236|Gammaproteobacteria,1XH63@135619|Oceanospirillales 135619|Oceanospirillales E Belongs to the GMC oxidoreductase family - - 1.1.99.1 ko:K00108 ko00260,ko01100,map00260,map01100 M00555 R01025 RC00087 ko00000,ko00001,ko00002,ko01000 - - - GMC_oxred_C,GMC_oxred_N k59_1283056_1 158500.BV97_05519 7.93e-163 469.0 COG2272@1|root,COG2272@2|Bacteria,1MVQZ@1224|Proteobacteria,2TTHT@28211|Alphaproteobacteria,2K0DZ@204457|Sphingomonadales 204457|Sphingomonadales I Belongs to the type-B carboxylesterase lipase family - - - ko:K03929 - - - - ko00000,ko01000 - CE10 - COesterase k59_1283056_2 158500.BV97_05518 6.94e-59 184.0 COG0662@1|root,COG0662@2|Bacteria,1RJH8@1224|Proteobacteria,2UAMN@28211|Alphaproteobacteria,2K4NN@204457|Sphingomonadales 204457|Sphingomonadales G Cupin domain - - - - - - - - - - - - Cupin_2 k59_1624713_1 52598.EE36_08508 2.72e-105 316.0 COG4664@1|root,COG4664@2|Bacteria,1R4MZ@1224|Proteobacteria,2TQNR@28211|Alphaproteobacteria,3ZW5Y@60136|Sulfitobacter 28211|Alphaproteobacteria Q Tripartite ATP-independent periplasmic transporter, DctM component - - - - - - - - - - - - DctM k59_385080_1 652103.Rpdx1_4081 2.78e-23 101.0 COG2826@1|root,COG2826@2|Bacteria,1PP49@1224|Proteobacteria,2TRVA@28211|Alphaproteobacteria,3JZ7D@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria L Integrase core domain - - - - - - - - - - - - HTH_38,rve k59_385080_2 702459.BBPR_0083 1.86e-10 64.3 COG2826@1|root,COG2826@2|Bacteria,2GMZX@201174|Actinobacteria,4D0DN@85004|Bifidobacteriales 201174|Actinobacteria L Transposase and inactivated derivatives IS30 family - - - - - - - - - - - - HTH_38,rve k59_1114168_1 1457393.AZ09_02280 4.69e-14 72.0 COG0527@1|root,COG0527@2|Bacteria,1MW3H@1224|Proteobacteria,2TRFA@28211|Alphaproteobacteria,2JPI1@204441|Rhodospirillales 204441|Rhodospirillales E Belongs to the aspartokinase family lysC - 2.7.2.4 ko:K00928 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00017,M00018,M00033,M00525,M00526,M00527 R00480 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase,ACT,ACT_7 k59_1114168_2 1122137.AQXF01000004_gene1844 6.76e-130 374.0 COG2227@1|root,COG2227@2|Bacteria,1MU89@1224|Proteobacteria,2TRIK@28211|Alphaproteobacteria 28211|Alphaproteobacteria H O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway ubiG - 2.1.1.222,2.1.1.64 ko:K00568 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00117 R04988,R05614,R08769,R08781 RC00003,RC00392,RC01895 ko00000,ko00001,ko00002,ko01000 - - - Methyltransf_11,Methyltransf_23 k59_436220_1 472759.Nhal_2771 5.87e-17 85.5 COG0532@1|root,COG0532@2|Bacteria,1MV26@1224|Proteobacteria,1RM9X@1236|Gammaproteobacteria,1WVXH@135613|Chromatiales 135613|Chromatiales J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex infB - - ko:K02519 - - - - ko00000,ko03012,ko03029 - - - GTP_EFTU,GTP_EFTU_D2,IF-2,IF2_N,IF2_assoc k59_212459_2 13690.CP98_02539 3.81e-53 175.0 COG3000@1|root,COG3000@2|Bacteria,1NXAF@1224|Proteobacteria,2U9R8@28211|Alphaproteobacteria,2K9UD@204457|Sphingomonadales 204457|Sphingomonadales I Fatty acid hydroxylase superfamily - - - - - - - - - - - - FA_hydroxylase k59_774116_1 1121272.KB903249_gene2033 2.48e-16 79.0 COG1132@1|root,COG1132@2|Bacteria,2GJYK@201174|Actinobacteria,4DBIN@85008|Micromonosporales 201174|Actinobacteria V ABC transporter ATPase permease - - - ko:K06147 - - - - ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_tran k59_774116_2 886293.Sinac_1560 3.82e-60 202.0 COG1132@1|root,COG1132@2|Bacteria,2IYCU@203682|Planctomycetes 2|Bacteria V ABC-type multidrug transport system ATPase and permease - - - ko:K06147,ko:K06148 - - - - ko00000,ko02000 3.A.1,3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_tran k59_723453_1 1125863.JAFN01000001_gene919 7.51e-81 249.0 COG1775@1|root,COG1775@2|Bacteria,1R9M8@1224|Proteobacteria,42PIZ@68525|delta/epsilon subdivisions,2WKP0@28221|Deltaproteobacteria 28221|Deltaproteobacteria E PFAM 2-hydroxyglutaryl-CoA dehydratase, D-component - - - - - - - - - - - iAF987.Gmet_0545 HGD-D k59_893516_2 1122137.AQXF01000002_gene248 1.14e-74 231.0 COG1280@1|root,COG1280@2|Bacteria,1MXAI@1224|Proteobacteria,2TSWP@28211|Alphaproteobacteria 28211|Alphaproteobacteria E lysine exporter protein (LysE YggA) - - - - - - - - - - - - LysE k59_893520_1 378753.KRH_21950 1.99e-14 72.4 COG0454@1|root,COG0456@2|Bacteria,2II3I@201174|Actinobacteria,1W9QJ@1268|Micrococcaceae 201174|Actinobacteria K Acetyltransferase (GNAT) family - - - - - - - - - - - - Acetyltransf_1,Acetyltransf_10,Acetyltransf_7 k59_893520_2 58123.JOFJ01000023_gene3544 6.05e-41 149.0 COG0657@1|root,COG0657@2|Bacteria,2GTEV@201174|Actinobacteria,4EPWP@85012|Streptosporangiales 201174|Actinobacteria I Carboxylesterase family lipM - - - - - - - - - - - Abhydrolase_3 k59_1114187_1 105559.Nwat_1955 1.02e-78 248.0 COG1295@1|root,COG1295@2|Bacteria,1MXQA@1224|Proteobacteria,1RP8E@1236|Gammaproteobacteria,1WXC5@135613|Chromatiales 135613|Chromatiales S ribonuclease BN - - - ko:K07058 - - - - ko00000 - - - Virul_fac_BrkB k59_1114187_2 1121931.AUHG01000011_gene2381 7.76e-14 72.4 COG0661@1|root,COG0661@2|Bacteria,4NDUP@976|Bacteroidetes,1HWK0@117743|Flavobacteriia 976|Bacteroidetes S unusual protein kinase - - - ko:K03688 - - - - ko00000 - - - ABC1 k59_1283092_1 1219076.N646_0834 3.76e-59 206.0 COG1020@1|root,COG1020@2|Bacteria,1QK4F@1224|Proteobacteria,1RPAG@1236|Gammaproteobacteria,1XSKY@135623|Vibrionales 135623|Vibrionales Q COG1020 Non-ribosomal peptide synthetase modules and related proteins - - 6.3.2.14 ko:K02364 ko01053,ko01110,ko01130,map01053,map01110,map01130 - R07644 RC00162,RC03046 ko00000,ko00001,ko01000,ko01008 - - - AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase k59_1114191_1 1137799.GZ78_12405 1.14e-15 81.3 COG3071@1|root,COG3071@2|Bacteria,1MU7A@1224|Proteobacteria,1RMRG@1236|Gammaproteobacteria,1XIR3@135619|Oceanospirillales 135619|Oceanospirillales H biosynthesis protein HemY hemY - - ko:K02498 - - - - ko00000 - - - HemY_N,TPR_7 k59_163671_2 1437882.AZRU01000020_gene6137 6.86e-66 216.0 COG0318@1|root,COG0318@2|Bacteria,1MWSD@1224|Proteobacteria,1RQ1C@1236|Gammaproteobacteria,1YHFK@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria IQ AMP-binding enzyme C-terminal domain - - 6.2.1.48 ko:K02182 - - - - ko00000,ko01000 - - - AMP-binding,AMP-binding_C k59_841688_1 1229909.NSED_06270 6.66e-153 444.0 COG0028@1|root,arCOG01998@2157|Archaea,41S63@651137|Thaumarchaeota 651137|Thaumarchaeota E TIGRFAM acetolactate synthase, large subunit, biosynthetic type - - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_499806_1 985054.JQEZ01000004_gene654 4.25e-51 171.0 COG3832@1|root,COG3832@2|Bacteria,1RDMX@1224|Proteobacteria,2TSWJ@28211|Alphaproteobacteria,4ND3B@97050|Ruegeria 28211|Alphaproteobacteria S Polyketide cyclase / dehydrase and lipid transport - - - - - - - - - - - - Polyketide_cyc2 k59_1522820_1 1027371.GOALK_097_00050 1.15e-10 66.2 COG0210@1|root,COG0210@2|Bacteria,2GKRW@201174|Actinobacteria,4GBFM@85026|Gordoniaceae 201174|Actinobacteria L HRDC domain uvrD2 GO:0000287,GO:0003674,GO:0003678,GO:0003824,GO:0004386,GO:0005488,GO:0006996,GO:0008094,GO:0008150,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0040007,GO:0042623,GO:0043167,GO:0043169,GO:0046872,GO:0051276,GO:0071103,GO:0071840,GO:0140097 3.6.4.12 ko:K03657 ko03420,ko03430,map03420,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - HRDC,UvrD-helicase,UvrD_C k59_618838_1 745411.B3C1_09682 2.42e-88 282.0 COG2010@1|root,COG2010@2|Bacteria,1R58S@1224|Proteobacteria,1RZ9B@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Cytochrome c - - - - - - - - - - - - - k59_1069498_1 983545.Glaag_0612 2.26e-54 194.0 COG1629@1|root,COG4771@2|Bacteria,1N6JG@1224|Proteobacteria,1RP10@1236|Gammaproteobacteria,465FE@72275|Alteromonadaceae 1236|Gammaproteobacteria P Carboxypeptidase regulatory-like domain - - - - - - - - - - - - CarboxypepD_reg,Plug,TonB_dep_Rec k59_841706_1 1049564.TevJSym_an00540 1.49e-33 122.0 COG2010@1|root,COG2010@2|Bacteria 2|Bacteria C Cytochrome c qcrC GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0040007,GO:0044425,GO:0044459,GO:0044464,GO:0071944 - ko:K00406,ko:K03889 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00151,M00156 - - ko00000,ko00001,ko00002 3.D.4.3 - - Cytochrome_CBB3 k59_555669_1 1458427.BAWN01000044_gene2075 2.81e-58 204.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2VHFI@28216|Betaproteobacteria,4AAY8@80864|Comamonadaceae 28216|Betaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K03296 - - - - ko00000 2.A.6.2 - - ACR_tran k59_618853_1 1229909.NSED_05780 1.49e-168 479.0 COG0001@1|root,arCOG00918@2157|Archaea,41S5Y@651137|Thaumarchaeota 651137|Thaumarchaeota H Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family - - 5.4.3.8 ko:K01845 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R02272 RC00677 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 k59_1410618_1 530564.Psta_1421 1.01e-66 222.0 COG1032@1|root,COG1032@2|Bacteria 2|Bacteria C radical SAM domain protein - - - - - - - - - - - - Radical_SAM k59_1181216_1 1273538.G159_05340 3.58e-82 251.0 COG3588@1|root,COG3588@2|Bacteria,1TPUJ@1239|Firmicutes,4HCG1@91061|Bacilli,26E3G@186818|Planococcaceae 91061|Bacilli G Belongs to the class I fructose-bisphosphate aldolase family fda - 4.1.2.13 ko:K01623 ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00003,M00165,M00167 R01068,R01070,R01829,R02568 RC00438,RC00439,RC00603,RC00604 ko00000,ko00001,ko00002,ko01000,ko03036,ko04131,ko04147 - - - Glycolytic k59_163711_1 1122201.AUAZ01000002_gene1133 6.34e-107 313.0 COG1484@1|root,COG1484@2|Bacteria,1MVU2@1224|Proteobacteria,1RNUA@1236|Gammaproteobacteria,4679W@72275|Alteromonadaceae 1236|Gammaproteobacteria L PFAM IstB domain protein ATP-binding protein - - - - - - - - - - - - IstB_IS21,IstB_IS21_ATP k59_1008166_1 555793.WSK_4111 6.9e-54 182.0 COG0535@1|root,COG0535@2|Bacteria,1MWDC@1224|Proteobacteria,2TSDD@28211|Alphaproteobacteria,2K8Y3@204457|Sphingomonadales 204457|Sphingomonadales C nitrogenase cofactor biosynthesis protein - - - ko:K02585 - - - - ko00000 - - - Nitro_FeMo-Co,Radical_SAM k59_1688453_1 443144.GM21_1625 4.04e-43 161.0 COG0557@1|root,COG0557@2|Bacteria,1MUS6@1224|Proteobacteria,42NGS@68525|delta/epsilon subdivisions,2WIWF@28221|Deltaproteobacteria,43TQ3@69541|Desulfuromonadales 28221|Deltaproteobacteria J 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs rnr - - ko:K12573 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03016,ko03019 - - - OB_RNB,RNB,S1 k59_164588_1 1096756.ATKN01000004_gene136 6.01e-44 152.0 COG1028@1|root,COG1028@2|Bacteria,2GVVR@201174|Actinobacteria 201174|Actinobacteria IQ Short-chain dehydrogenase reductase sdr - - - - - - - - - - - - adh_short_C2 k59_953644_1 1280949.HAD_09385 7.85e-99 311.0 COG1391@1|root,COG1391@2|Bacteria,1MU4I@1224|Proteobacteria,2TRY7@28211|Alphaproteobacteria,43WTT@69657|Hyphomonadaceae 28211|Alphaproteobacteria H Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell glnE GO:0000820,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006521,GO:0008150,GO:0008882,GO:0010565,GO:0016740,GO:0016772,GO:0016779,GO:0019222,GO:0031323,GO:0033238,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0062012,GO:0065007,GO:0070566,GO:0080090 2.7.7.42,2.7.7.89 ko:K00982 - - - - ko00000,ko01000 - - - GlnD_UR_UTase,GlnE k59_394521_2 1122137.AQXF01000003_gene1878 1.44e-41 139.0 COG3027@1|root,COG3027@2|Bacteria 2|Bacteria D Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division zapA - - ko:K09888 - - - - ko00000,ko03036 - - - ZapA k59_1411509_2 400668.Mmwyl1_2459 3.52e-35 127.0 COG0517@1|root,COG0517@2|Bacteria,1RJTX@1224|Proteobacteria,1S6K2@1236|Gammaproteobacteria,1XJHR@135619|Oceanospirillales 135619|Oceanospirillales S CBS domain containing protein - - - - - - - - - - - - CBS k59_1634111_1 1304275.C41B8_08815 6.13e-50 167.0 COG0413@1|root,COG0413@2|Bacteria,1MU3B@1224|Proteobacteria,1RM8D@1236|Gammaproteobacteria 1236|Gammaproteobacteria H Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate panB GO:0000287,GO:0003674,GO:0003824,GO:0003864,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006573,GO:0006575,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016740,GO:0016741,GO:0016742,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0042364,GO:0042398,GO:0042802,GO:0043167,GO:0043169,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046872,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.1.2.11 ko:K00606 ko00770,ko01100,ko01110,map00770,map01100,map01110 M00119 R01226 RC00022,RC00200 ko00000,ko00001,ko00002,ko01000 - - iB21_1397.B21_00132,iE2348C_1286.E2348C_0137,iECBD_1354.ECBD_3485,iECB_1328.ECB_00133,iECD_1391.ECD_00133,iPC815.YPO3401 Pantoate_transf k59_1634111_2 555778.Hneap_0059 3.28e-18 79.3 COG1671@1|root,COG1671@2|Bacteria,1RCZA@1224|Proteobacteria,1S3QM@1236|Gammaproteobacteria,1WYBE@135613|Chromatiales 135613|Chromatiales S Belongs to the UPF0178 family - - - ko:K09768 - - - - ko00000 - - - DUF188 k59_221737_1 1122137.AQXF01000006_gene885 6e-114 334.0 COG1058@1|root,COG1058@2|Bacteria,1MVG6@1224|Proteobacteria,2TU5C@28211|Alphaproteobacteria 28211|Alphaproteobacteria S nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA cinA1 - - - - - - - - - - - MoCF_biosynth k59_842671_1 493475.GARC_1933 2.96e-94 284.0 COG0518@1|root,COG0518@2|Bacteria 2|Bacteria F GMP synthase (glutamine-hydrolyzing) activity - - 6.3.5.2 ko:K01951 ko00230,ko00983,ko01100,map00230,map00983,map01100 M00050 R01230,R01231,R08244 RC00010,RC00204 ko00000,ko00001,ko00002,ko01000,ko01002 - - - GATase k59_842671_2 342113.DM82_790 8.17e-13 70.5 COG2207@1|root,COG2207@2|Bacteria,1RH01@1224|Proteobacteria,2VQ3J@28216|Betaproteobacteria,1K3U6@119060|Burkholderiaceae 28216|Betaproteobacteria K PFAM helix-turn-helix- domain containing protein AraC type - - - - - - - - - - - - Arabinose_bd,HTH_18 k59_619828_1 240292.Ava_3596 0.000262 48.9 COG0515@1|root,COG2203@1|root,COG3899@1|root,COG4191@1|root,COG0515@2|Bacteria,COG2203@2|Bacteria,COG3899@2|Bacteria,COG4191@2|Bacteria,1GI1T@1117|Cyanobacteria,1HQGF@1161|Nostocales 1117|Cyanobacteria T AAA ATPase domain - - 2.7.1.37 ko:K00870 - - - - ko00000 - - - AAA_16,GAF,HATPase_c,Pkinase k59_1689375_1 589865.DaAHT2_1453 2.38e-51 164.0 COG0051@1|root,COG0051@2|Bacteria,1RGWF@1224|Proteobacteria,42SE4@68525|delta/epsilon subdivisions,2WP4K@28221|Deltaproteobacteria,2MK4M@213118|Desulfobacterales 28221|Deltaproteobacteria J Involved in the binding of tRNA to the ribosomes rpsJ GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02946 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S10 k59_1689375_2 1380391.JIAS01000003_gene1706 4.52e-147 422.0 COG0050@1|root,COG0050@2|Bacteria,1MVC0@1224|Proteobacteria,2TQP8@28211|Alphaproteobacteria,2JPKS@204441|Rhodospirillales 204441|Rhodospirillales J This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis tuf GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - ko:K02358 - - - - ko00000,ko03012,ko03029,ko04147 - - - GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3 k59_1581333_1 1121451.DESAM_21040 5.33e-40 139.0 COG0681@1|root,COG0681@2|Bacteria,1MXUF@1224|Proteobacteria,42NJE@68525|delta/epsilon subdivisions,2WKMA@28221|Deltaproteobacteria,2M9N8@213115|Desulfovibrionales 28221|Deltaproteobacteria U Belongs to the peptidase S26 family lepB - 3.4.21.89 ko:K03100 ko02024,ko03060,map02024,map03060 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_S24,Peptidase_S26 k59_1581333_2 713586.KB900536_gene177 1.35e-91 288.0 COG0481@1|root,COG0481@2|Bacteria,1MVZA@1224|Proteobacteria,1RPFB@1236|Gammaproteobacteria,1WW67@135613|Chromatiales 135613|Chromatiales M Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner lepA - - ko:K03596 ko05134,map05134 - - - ko00000,ko00001 - - - EFG_C,EFG_II,GTP_EFTU,GTP_EFTU_D2,LepA_C k59_1123409_1 999141.GME_16072 1.26e-51 172.0 COG1028@1|root,COG1028@2|Bacteria,1MWBC@1224|Proteobacteria,1RNNV@1236|Gammaproteobacteria,1XH47@135619|Oceanospirillales 135619|Oceanospirillales IQ reductase - - - - - - - - - - - - adh_short k59_1348738_1 1122137.AQXF01000006_gene718 3.86e-239 661.0 COG3825@1|root,COG3825@2|Bacteria,1MUAJ@1224|Proteobacteria,2TS5P@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Protein conserved in bacteria MA20_01305 - - ko:K09989 - - - - ko00000 - - - VWA_CoxE k59_1689389_1 706587.Desti_0714 5.17e-96 289.0 COG0730@1|root,COG0730@2|Bacteria,1Q05R@1224|Proteobacteria,42NT9@68525|delta/epsilon subdivisions,2WJVB@28221|Deltaproteobacteria 28221|Deltaproteobacteria S membrane transporter protein - - - ko:K07090 - - - - ko00000 - - - TauE k59_1523812_1 555793.WSK_1767 3.82e-106 322.0 COG2710@1|root,COG2710@2|Bacteria,1MWAJ@1224|Proteobacteria,2TQUV@28211|Alphaproteobacteria 28211|Alphaproteobacteria C Belongs to the NifD NifK NifE NifN family nifE - - ko:K02587 - - - - ko00000 - - - Fer2_BFD,Oxidored_nitro k59_953695_1 983544.Lacal_1601 5.23e-55 179.0 COG0739@1|root,COG0739@2|Bacteria,4NGHH@976|Bacteroidetes,1HX46@117743|Flavobacteriia 976|Bacteroidetes M Peptidase, M23 mepM_1 - - - - - - - - - - - Peptidase_M23 k59_953695_2 867900.Celly_0695 2.79e-54 171.0 COG0789@1|root,COG0789@2|Bacteria,4NSBD@976|Bacteroidetes,1I2UP@117743|Flavobacteriia,1F9F2@104264|Cellulophaga 976|Bacteroidetes K helix_turn_helix, mercury resistance ycgE - - - - - - - - - - - MerR_1 k59_842684_1 502025.Hoch_4506 8.55e-38 133.0 COG0359@1|root,COG0359@2|Bacteria,1RD0R@1224|Proteobacteria,42SCQ@68525|delta/epsilon subdivisions,2WPZQ@28221|Deltaproteobacteria,2YX0Q@29|Myxococcales 28221|Deltaproteobacteria J binds to the 23S rRNA rplI GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02939 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L9_C,Ribosomal_L9_N k59_842684_2 997346.HMPREF9374_2485 7.37e-22 97.8 COG0305@1|root,COG0305@2|Bacteria,1TPCT@1239|Firmicutes,4H9Y8@91061|Bacilli,27BA0@186824|Thermoactinomycetaceae 91061|Bacilli L DnaB-like helicase C terminal domain dnaB GO:0003674,GO:0003678,GO:0003824,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006268,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0032392,GO:0032508,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051276,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360,GO:1901576 3.6.4.12 ko:K02314 ko03030,ko04112,map03030,map04112 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB,DnaB_C k59_1237939_1 536019.Mesop_2967 8.53e-72 229.0 COG0500@1|root,COG0500@2|Bacteria,1MVD1@1224|Proteobacteria,2TUKG@28211|Alphaproteobacteria,43MUV@69277|Phyllobacteriaceae 28211|Alphaproteobacteria Q C-methyltransferase C-terminal domain - - - - - - - - - - - - Methyltransf_13,Methyltransf_14,Methyltransf_23 k59_164610_1 1453501.JELR01000006_gene18 5.99e-38 144.0 29DUJ@1|root,300SF@2|Bacteria,1RFSI@1224|Proteobacteria,1S4KD@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_1634143_1 1229909.NSED_09335 2.58e-142 417.0 arCOG08764@1|root,arCOG08764@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_1634153_1 1280953.HOC_16673 3.94e-31 126.0 COG1629@1|root,COG4771@2|Bacteria,1MUNK@1224|Proteobacteria,2TRCG@28211|Alphaproteobacteria,43WM8@69657|Hyphomonadaceae 28211|Alphaproteobacteria P COG1629 Outer membrane receptor proteins, mostly Fe transport - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_445533_1 388051.AUFE01000006_gene1273 1.57e-65 213.0 COG1533@1|root,COG1533@2|Bacteria,1MW0H@1224|Proteobacteria,2VIYE@28216|Betaproteobacteria,1K1PF@119060|Burkholderiaceae 28216|Betaproteobacteria L PFAM Radical SAM domain protein splB - - - - - - - - - - - Radical_SAM k59_842699_1 1122137.AQXF01000002_gene369 9.78e-71 223.0 COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,2TQKE@28211|Alphaproteobacteria 28211|Alphaproteobacteria I acyl-CoA dehydrogenase - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_842699_2 1122137.AQXF01000002_gene368 1.48e-29 114.0 COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,2TQQ7@28211|Alphaproteobacteria 28211|Alphaproteobacteria I Belongs to the thiolase family - - 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N k59_1798796_1 402881.Plav_0548 2.18e-73 228.0 COG1028@1|root,COG1028@2|Bacteria,1PFTU@1224|Proteobacteria,2V7R9@28211|Alphaproteobacteria,1JQ79@119043|Rhodobiaceae 402881.Plav_0548|- IQ KR domain - - - - - - - - - - - - - k59_1009039_1 744980.TRICHSKD4_2688 4.59e-86 271.0 COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,2TSTW@28211|Alphaproteobacteria 28211|Alphaproteobacteria EH Belongs to the TPP enzyme family ilvB - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_783138_1 118161.KB235922_gene2821 3.2e-05 49.3 COG1028@1|root,COG1028@2|Bacteria,1G2PQ@1117|Cyanobacteria,3VMBB@52604|Pleurocapsales 1117|Cyanobacteria IQ Enoyl-(Acyl carrier protein) reductase - - 1.1.1.100 ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 k59_164657_1 1127673.GLIP_1145 3.52e-46 164.0 COG1459@1|root,COG1459@2|Bacteria,1MV4U@1224|Proteobacteria,1RQMI@1236|Gammaproteobacteria,464EE@72275|Alteromonadaceae 1236|Gammaproteobacteria NU Type II secretory pathway, component PulF mshG - - ko:K02505,ko:K12278 - - - - ko00000,ko02044 - - - T2SSF k59_221786_1 247634.GPB2148_3364 6.68e-64 205.0 COG2365@1|root,COG2365@2|Bacteria,1R4XF@1224|Proteobacteria,1RMPM@1236|Gammaproteobacteria,1J6AE@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T COG2365 Protein tyrosine serine phosphatase - - - - - - - - - - - - Y_phosphatase3 k59_1634169_1 1121918.ARWE01000001_gene2635 4.37e-89 292.0 COG0067@1|root,COG0069@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,1MU7B@1224|Proteobacteria,42MF7@68525|delta/epsilon subdivisions,2WJBR@28221|Deltaproteobacteria,43SWP@69541|Desulfuromonadales 28221|Deltaproteobacteria E glutamate synthase, alpha subunit domain protein gltB1 - 1.4.1.13,1.4.1.14,1.4.7.1 ko:K00265,ko:K00284 ko00250,ko00630,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00630,map00910,map01100,map01110,map01120,map01130,map01230 - R00021,R00093,R00114,R00248,R10086 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - GATase_2,GXGXG,Glu_syn_central,Glu_synthase k59_1634169_2 1121918.ARWE01000001_gene2634 1.31e-61 201.0 COG0493@1|root,COG0493@2|Bacteria,1MU2H@1224|Proteobacteria,42MGY@68525|delta/epsilon subdivisions,2X1WM@28221|Deltaproteobacteria,43TUG@69541|Desulfuromonadales 28221|Deltaproteobacteria E Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster - - 1.4.1.13,1.4.1.14 ko:K00266 ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 - R00093,R00114,R00248 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - Fer4_20,Pyr_redox_2 k59_1462542_1 1121285.AUFK01000009_gene1033 8.77e-28 114.0 COG4585@1|root,COG4585@2|Bacteria,4NS8E@976|Bacteroidetes,1I84Y@117743|Flavobacteriia,3ZQM0@59732|Chryseobacterium 976|Bacteroidetes T Histidine kinase - - 2.7.13.3 ko:K07778 ko02020,map02020 M00479 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA_3 k59_1462542_2 1121889.AUDM01000002_gene450 7.63e-40 137.0 COG2197@1|root,COG2197@2|Bacteria,4NHTM@976|Bacteroidetes,1HXC7@117743|Flavobacteriia,2NT1Y@237|Flavobacterium 976|Bacteroidetes T helix_turn_helix, Lux Regulon - - - - - - - - - - - - GerE,Response_reg k59_394591_1 1123326.JFBL01000011_gene222 1.13e-14 85.1 COG1033@1|root,COG1033@2|Bacteria,1MUE1@1224|Proteobacteria,42ME2@68525|delta/epsilon subdivisions,2YM9E@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S MMPL family - - - ko:K07003 - - - - ko00000 - - - MMPL,Patched k59_394593_1 1121434.AULY01000006_gene929 7.88e-61 210.0 COG0668@1|root,COG0668@2|Bacteria,1MXD2@1224|Proteobacteria,43C4Y@68525|delta/epsilon subdivisions,2X7FA@28221|Deltaproteobacteria 28221|Deltaproteobacteria M Mechanosensitive ion channel - - - - - - - - - - - - MS_channel k59_842729_1 379066.GAU_1376 2.05e-79 245.0 COG2070@1|root,COG2070@2|Bacteria,1ZUN8@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Nitronate monooxygenase - - 1.13.12.16 ko:K00459 ko00910,map00910 - R00025 RC02541,RC02759 ko00000,ko00001,ko01000 - - - NMO k59_1182222_1 1211815.CBYP010000067_gene114 1.66e-138 409.0 COG0318@1|root,COG0318@2|Bacteria,2GJAA@201174|Actinobacteria,4EU2I@85013|Frankiales 201174|Actinobacteria IQ PFAM AMP-dependent synthetase and ligase - - 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding,AMP-binding_C k59_556606_1 1123503.KB908056_gene2060 7.87e-08 52.8 COG0484@1|root,COG0484@2|Bacteria,1MVMS@1224|Proteobacteria,2TRZ1@28211|Alphaproteobacteria,2KF8X@204458|Caulobacterales 204458|Caulobacterales O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins dnaJ - - ko:K03686 - - - - ko00000,ko03029,ko03110 - - - DnaJ,DnaJ_C,DnaJ_CXXCXGXG k59_556606_2 1122137.AQXF01000001_gene3255 5.2e-53 184.0 COG0443@1|root,COG0443@2|Bacteria,1MVEN@1224|Proteobacteria,2TR5H@28211|Alphaproteobacteria 28211|Alphaproteobacteria O Heat shock 70 kDa protein dnaK - - ko:K04043 ko03018,ko04212,ko05152,map03018,map04212,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 1.A.33.1 - - HSP70 k59_1634190_2 436229.JOEH01000004_gene55 2.01e-109 334.0 COG0442@1|root,COG0442@2|Bacteria,2GJ9G@201174|Actinobacteria,2NM7I@228398|Streptacidiphilus 201174|Actinobacteria J Aminoacyl-tRNA editing domain proS GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944 6.1.1.15 ko:K01881 ko00970,map00970 M00359,M00360 R03661 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,tRNA-synt_2b,tRNA_edit k59_337563_1 1122137.AQXF01000005_gene1091 2.06e-14 70.1 COG5336@1|root,COG5336@2|Bacteria 2|Bacteria C function for this protein is to guide the assembly of the membrane sector of the ATPase enzyme complex atpI - - ko:K02116 - - - - ko00000,ko00194 3.A.2.1 - - ATPase_gene1 k59_337563_2 1122137.AQXF01000005_gene1090 3.84e-12 64.7 COG0356@1|root,COG0356@2|Bacteria,1MV87@1224|Proteobacteria,2TRNV@28211|Alphaproteobacteria 28211|Alphaproteobacteria C it plays a direct role in the translocation of protons across the membrane atpB - - ko:K02108 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko03110 3.A.2.1 - - ATP-synt_A k59_556611_2 58344.JOEL01000016_gene5922 6.99e-61 207.0 COG0654@1|root,COG0654@2|Bacteria,2GK88@201174|Actinobacteria 201174|Actinobacteria CH PFAM monooxygenase FAD-binding mhpA - 1.14.13.219 ko:K20943 ko00362,ko01120,map00362,map01120 - R05249 RC00046 ko00000,ko00001,ko01000 - - - FAD_binding_3 k59_1523866_1 273526.SMDB11_4061 6.53e-66 216.0 COG1519@1|root,COG1519@2|Bacteria,1MU9F@1224|Proteobacteria,1RNBR@1236|Gammaproteobacteria,400EJ@613|Serratia 1236|Gammaproteobacteria M Catalyzes the transfer of 2-keto-3-deoxy-D-manno-octulosonic acid to lipid A kdtA - 2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15 ko:K02527 ko00540,ko01100,map00540,map01100 M00060,M00080 R04658,R05074,R09763 RC00009,RC00077,RC00247 ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT30 - Glycos_transf_1,Glycos_transf_N k59_1348796_1 396588.Tgr7_0241 9.4e-55 193.0 COG4772@1|root,COG4772@2|Bacteria,1MUIH@1224|Proteobacteria,1RQYX@1236|Gammaproteobacteria,1X2PP@135613|Chromatiales 135613|Chromatiales P TonB-dependent Receptor Plug - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_1746391_1 639030.JHVA01000001_gene1282 6.4e-33 125.0 COG0714@1|root,COG0714@2|Bacteria,3Y3BH@57723|Acidobacteria,2JP47@204432|Acidobacteriia 204432|Acidobacteriia S ATPase family associated with various cellular activities (AAA) - - - ko:K03924 - - - - ko00000,ko01000 - - - AAA_3 k59_1689449_1 261292.Nit79A3_2089 7.4e-107 322.0 COG0766@1|root,COG0766@2|Bacteria,1MUH7@1224|Proteobacteria,2VHZN@28216|Betaproteobacteria,371PY@32003|Nitrosomonadales 28216|Betaproteobacteria M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine murA - 2.5.1.7 ko:K00790 ko00520,ko00550,ko01100,map00520,map00550,map01100 - R00660 RC00350 ko00000,ko00001,ko01000,ko01011 - - - EPSP_synthase k59_1689449_2 1131553.JIBI01000003_gene1672 7.81e-09 52.8 COG5007@1|root,COG5007@2|Bacteria,1MZCZ@1224|Proteobacteria,2VU0K@28216|Betaproteobacteria,373HW@32003|Nitrosomonadales 28216|Betaproteobacteria K Belongs to the BolA IbaG family yrbA - - - - - - - - - - - BolA k59_1123475_1 748247.AZKH_2835 9.46e-43 147.0 COG0571@1|root,COG0571@2|Bacteria,1MUQ6@1224|Proteobacteria,2VI4M@28216|Betaproteobacteria,2KW7B@206389|Rhodocyclales 206389|Rhodocyclales J Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism rnc - 3.1.26.3 ko:K03685 ko03008,ko05205,map03008,map05205 - - - ko00000,ko00001,ko01000,ko03009,ko03019,ko03036 - - - Ribonucleas_3_3,dsrm k59_1123475_2 95619.PM1_0216770 6.7e-39 139.0 COG1159@1|root,COG1159@2|Bacteria,1MUKT@1224|Proteobacteria,1RN3A@1236|Gammaproteobacteria 1236|Gammaproteobacteria J An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism era GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009898,GO:0009987,GO:0016020,GO:0016310,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019538,GO:0019843,GO:0019897,GO:0019898,GO:0022613,GO:0031234,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0036211,GO:0042254,GO:0042274,GO:0043021,GO:0043024,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0044877,GO:0046777,GO:0070181,GO:0071704,GO:0071840,GO:0071944,GO:0097159,GO:0097367,GO:0098552,GO:0098562,GO:1901265,GO:1901363,GO:1901564 - ko:K03595 - - - - ko00000,ko03009,ko03029 - - - KH_2,MMR_HSR1 k59_1070569_2 1286093.C266_17721 6.59e-30 118.0 COG0339@1|root,COG0339@2|Bacteria,1MU1K@1224|Proteobacteria,2VHPQ@28216|Betaproteobacteria,1K0UB@119060|Burkholderiaceae 28216|Betaproteobacteria E PFAM peptidase M3A and M3B, thimet oligopeptidase F prlC - 3.4.24.70 ko:K01414 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M3 k59_1292803_1 316274.Haur_4103 5.82e-48 165.0 2DBC8@1|root,2Z8C9@2|Bacteria,2G9UH@200795|Chloroflexi,3774U@32061|Chloroflexia 32061|Chloroflexia - - - - - - - - - - - - - - - k59_337588_1 717606.PaecuDRAFT_4075 6.85e-61 200.0 COG0649@1|root,COG0649@2|Bacteria,1TQAR@1239|Firmicutes,4HA4Y@91061|Bacilli,26T7E@186822|Paenibacillaceae 91061|Bacilli C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoD GO:0003674,GO:0003824,GO:0003954,GO:0008137,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0016655,GO:0050136,GO:0055114 1.6.5.3 ko:K00333 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_49kDa k59_500692_1 1415778.JQMM01000001_gene2054 1.6e-66 207.0 COG0755@1|root,COG0755@2|Bacteria,1MU61@1224|Proteobacteria,1RP3R@1236|Gammaproteobacteria,1J54R@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria U Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes ccmC GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0008152,GO:0015886,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051181,GO:0051234,GO:0055114,GO:0071702,GO:0071705,GO:0071944,GO:1901678 - ko:K02195 ko02010,map02010 M00259 - - ko00000,ko00001,ko00002,ko02000 3.A.1.107 - iECDH1ME8569_1439.ECDH1ME8569_2134,iSFV_1184.SFV_2275,iSFxv_1172.SFxv_2517,iUTI89_1310.UTI89_C2477,ic_1306.c2736 Cytochrom_C_asm k59_500692_2 1415778.JQMM01000001_gene2055 9.44e-08 52.8 COG2386@1|root,COG2386@2|Bacteria,1NJB0@1224|Proteobacteria,1RRFJ@1236|Gammaproteobacteria,1J5R7@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria U Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes ccmB GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0031224,GO:0031226,GO:0032991,GO:0042623,GO:0043190,GO:0044425,GO:0044459,GO:0044464,GO:0071944,GO:0098533,GO:0098796,GO:0098797,GO:1902494,GO:1902495,GO:1904949,GO:1990351 - ko:K02194 ko02010,map02010 M00259 - - ko00000,ko00001,ko00002,ko02000 3.A.1.107 - iECO111_1330.ECO111_2936,iYL1228.KPN_02080 CcmB k59_1689462_1 243159.AFE_1767 3.16e-44 153.0 COG0847@1|root,COG0847@2|Bacteria,1RBBK@1224|Proteobacteria,1S6T7@1236|Gammaproteobacteria,2NC6N@225057|Acidithiobacillales 225057|Acidithiobacillales L Putative quorum-sensing-regulated virulence factor - - - ko:K10857 ko03430,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - QSregVF_b,RNase_T k59_164724_1 436308.Nmar_1490 8.52e-84 257.0 COG0180@1|root,arCOG01887@2157|Archaea,41SDK@651137|Thaumarchaeota 651137|Thaumarchaeota J Belongs to the class-I aminoacyl-tRNA synthetase family - - 6.1.1.2 ko:K01867 ko00970,map00970 M00359,M00360 R03664 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_1b k59_164724_2 1131266.ARWQ01000001_gene1125 5.65e-10 56.2 arCOG10585@1|root,arCOG10585@2157|Archaea,41SW6@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1009086_1 1379270.AUXF01000006_gene18 2.39e-11 65.5 COG2885@1|root,COG2885@2|Bacteria,1ZTSM@142182|Gemmatimonadetes 142182|Gemmatimonadetes M OmpA family - - - ko:K03640 - - - - ko00000,ko02000 2.C.1.2 - - OmpA k59_337611_2 1229909.NSED_08180 4.43e-49 156.0 COG1522@1|root,arCOG01117@2157|Archaea,41ST7@651137|Thaumarchaeota 651137|Thaumarchaeota K Lrp/AsnC ligand binding domain - - - - - - - - - - - - AsnC_trans_reg k59_337611_3 436308.Nmar_1484 4.7e-35 124.0 arCOG08639@1|root,arCOG08639@2157|Archaea,41SP8@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1634223_1 396588.Tgr7_0102 3.48e-56 189.0 COG0452@1|root,COG0452@2|Bacteria,1MVQP@1224|Proteobacteria,1RMKQ@1236|Gammaproteobacteria,1WXCF@135613|Chromatiales 135613|Chromatiales H Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine - - 4.1.1.36,6.3.2.5 ko:K13038 ko00770,ko01100,map00770,map01100 M00120 R03269,R04231 RC00064,RC00090,RC00822 ko00000,ko00001,ko00002,ko01000 - - - DFP,Flavoprotein k59_1523906_1 1193181.BN10_520065 1.95e-29 119.0 COG1316@1|root,COG1316@2|Bacteria,2GJJJ@201174|Actinobacteria,4FEU8@85021|Intrasporangiaceae 201174|Actinobacteria K transcriptional regulator lytR2 - - - - - - - - - - - LytR_cpsA_psr k59_286006_1 272568.GDI3670 1.98e-31 132.0 COG0234@1|root,COG0234@2|Bacteria,1NJKP@1224|Proteobacteria,2UM25@28211|Alphaproteobacteria 28211|Alphaproteobacteria O Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter - - - ko:K04078 - - - - ko00000,ko03029,ko03110 - - - - k59_286006_2 140626.JHWB01000016_gene2351 3.17e-07 52.8 COG0234@1|root,COG0234@2|Bacteria,1V9ZM@1239|Firmicutes,24MMM@186801|Clostridia 186801|Clostridia O Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter groS - - ko:K04078 - - - - ko00000,ko03029,ko03110 - - - Cpn10 k59_286006_6 1280944.HY17_04670 1.24e-61 203.0 2DVPY@1|root,33WQ8@2|Bacteria,1N9VQ@1224|Proteobacteria,2UIC5@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_1020586_1 436308.Nmar_0510 1.37e-30 118.0 COG0373@1|root,arCOG01036@2157|Archaea,41SDM@651137|Thaumarchaeota 651137|Thaumarchaeota H Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) - - 1.2.1.70 ko:K02492 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R04109 RC00055,RC00149 ko00000,ko00001,ko00002,ko01000 - - - GlutR_N,GlutR_dimer,Shikimate_DH k59_1020586_2 436308.Nmar_0509 1.15e-23 97.4 COG0113@1|root,arCOG04300@2157|Archaea,41SET@651137|Thaumarchaeota 651137|Thaumarchaeota H Delta-aminolevulinic acid dehydratase - - 4.2.1.24 ko:K01698 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R00036 RC00918,RC01781 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ALAD k59_342570_2 637905.SVI_4341 1.91e-53 176.0 COG0356@1|root,COG0356@2|Bacteria,1MV87@1224|Proteobacteria,1RPHK@1236|Gammaproteobacteria,2Q8ZH@267890|Shewanellaceae 1236|Gammaproteobacteria C it plays a direct role in the translocation of protons across the membrane atpB GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0005887,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016021,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0031224,GO:0031226,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0042777,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045263,GO:0045264,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - ko:K02108 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko03110 3.A.2.1 - iAPECO1_1312.APECO1_2725,iE2348C_1286.E2348C_4048,iEC042_1314.EC042_4125,iECABU_c1320.ECABU_c42230,iECED1_1282.ECED1_4428,iECIAI39_1322.ECIAI39_4342,iECNA114_1301.ECNA114_3887,iECOK1_1307.ECOK1_4187,iECP_1309.ECP_3937,iECS88_1305.ECS88_4160,iECSF_1327.ECSF_3586,iECUMN_1333.ECUMN_4268,iEcSMS35_1347.EcSMS35_4106,iLF82_1304.LF82_0192,iNRG857_1313.NRG857_18615,iUMN146_1321.UM146_18880,iUMNK88_1353.UMNK88_4550,iUTI89_1310.UTI89_C4293,ic_1306.c4666 ATP-synt_A k59_116697_1 1120934.KB894432_gene6137 6.01e-56 184.0 2C73B@1|root,330Z7@2|Bacteria,2IIMQ@201174|Actinobacteria,4E6EA@85010|Pseudonocardiales 201174|Actinobacteria - - - - - - - - - - - - - - DUF998 k59_1076467_1 1229909.NSED_02200 1.58e-73 224.0 COG0066@1|root,arCOG02230@2157|Archaea,41T1U@651137|Thaumarchaeota 651137|Thaumarchaeota E 3-isopropylmalate dehydratase, small subunit - - 4.2.1.33,4.2.1.35 ko:K01704 ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230 M00432,M00535 R03896,R03898,R03968,R04001,R10170 RC00976,RC00977,RC01041,RC01046,RC03072 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase_C k59_1528738_1 1122137.AQXF01000005_gene1207 4.16e-164 482.0 COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2TQR1@28211|Alphaproteobacteria 28211|Alphaproteobacteria C belongs to the aldehyde dehydrogenase family aldA - 1.2.1.3 ko:K00128 ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130 M00135 R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146 RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_1020599_1 1267600.JFGT01000004_gene3363 6.79e-98 305.0 COG1200@1|root,COG1200@2|Bacteria,1MWN2@1224|Proteobacteria,1RMMQ@1236|Gammaproteobacteria,3VZ34@53335|Pantoea 1236|Gammaproteobacteria L Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) recG GO:0003674,GO:0003678,GO:0003724,GO:0003824,GO:0004003,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006807,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0008186,GO:0009314,GO:0009379,GO:0009628,GO:0009987,GO:0010501,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0032991,GO:0033202,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0051276,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:0140098,GO:1901360,GO:1902494 3.6.4.12 ko:K03655 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,Helicase_C,RecG_wedge k59_681217_1 1122137.AQXF01000005_gene1072 4.03e-85 261.0 COG0646@1|root,COG0646@2|Bacteria,1NPFY@1224|Proteobacteria,2UJRS@28211|Alphaproteobacteria 28211|Alphaproteobacteria E COG0646 Methionine synthase I (cobalamin-dependent), methyltransferase domain metH - 2.1.1.13,2.1.1.5 ko:K00544,ko:K00548 ko00260,ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00260,map00270,map00450,map00670,map01100,map01110,map01230 M00017 R00946,R02821,R09365 RC00035,RC00113,RC00496,RC01241 ko00000,ko00001,ko00002,ko01000 - - - S-methyl_trans k59_681217_2 1122137.AQXF01000005_gene1071 2.2e-75 247.0 COG1410@1|root,COG1410@2|Bacteria,1MV6G@1224|Proteobacteria,2TQTG@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Methionine synthase metH GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006464,GO:0006479,GO:0006520,GO:0006555,GO:0006575,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0008213,GO:0008270,GO:0008276,GO:0008652,GO:0008705,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0019538,GO:0019752,GO:0019842,GO:0031419,GO:0032259,GO:0034641,GO:0035999,GO:0036094,GO:0036211,GO:0042084,GO:0042558,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043414,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046653,GO:0046872,GO:0046906,GO:0046914,GO:0048037,GO:0050667,GO:0051186,GO:0071704,GO:0097159,GO:0140096,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.1.1.13 ko:K00548 ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230 M00017 R00946,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 - - - B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans k59_1754603_1 315750.BPUM_1808 4.09e-09 57.4 COG4677@1|root,COG4677@2|Bacteria,1UYI6@1239|Firmicutes,4HVBT@91061|Bacilli,1ZPW4@1386|Bacillus 91061|Bacilli M Pectinesterase - - 3.1.1.11 ko:K01051 ko00040,ko01100,map00040,map01100 M00081 R02362 RC00460,RC00461 ko00000,ko00001,ko00002,ko01000 - - - Pectinesterase k59_1754603_2 1121931.AUHG01000010_gene456 1.9e-44 155.0 COG4225@1|root,COG4225@2|Bacteria,4NIET@976|Bacteroidetes,1I0HZ@117743|Flavobacteriia 976|Bacteroidetes S Domain of unknown function (DUF4861) - - - - - - - - - - - - DUF4861 k59_963686_1 768671.ThimaDRAFT_2639 2.74e-07 50.1 COG0314@1|root,COG0314@2|Bacteria,1RGUX@1224|Proteobacteria,1S5YH@1236|Gammaproteobacteria,1WYCE@135613|Chromatiales 135613|Chromatiales H PFAM molybdopterin biosynthesis MoaE - - 2.8.1.12 ko:K03635 ko00790,ko01100,ko04122,map00790,map01100,map04122 - R09395 RC02507 ko00000,ko00001,ko01000 - - - MoaE k59_963686_2 314278.NB231_13856 3.03e-41 141.0 COG0071@1|root,COG0071@2|Bacteria,1N7C7@1224|Proteobacteria,1S607@1236|Gammaproteobacteria,1WYTK@135613|Chromatiales 135613|Chromatiales O Belongs to the small heat shock protein (HSP20) family - - - ko:K13993 ko04141,map04141 - - - ko00000,ko00001,ko03110 - - - HSP20 k59_738138_1 1279017.AQYJ01000024_gene1093 2.96e-69 219.0 COG0739@1|root,COG0739@2|Bacteria,1MVTF@1224|Proteobacteria,1RMIR@1236|Gammaproteobacteria,465Y3@72275|Alteromonadaceae 1236|Gammaproteobacteria M COG0739 Membrane proteins related to metalloendopeptidases - - - - - - - - - - - - Peptidase_M23 k59_1698150_1 667632.KB890176_gene4513 1.01e-97 298.0 COG0064@1|root,COG0064@2|Bacteria,1MUKG@1224|Proteobacteria,2VI3A@28216|Betaproteobacteria,1K1TI@119060|Burkholderiaceae 28216|Betaproteobacteria J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) gatB - 6.3.5.6,6.3.5.7 ko:K02434 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - GatB_N,GatB_Yqey k59_1698150_2 1123393.KB891330_gene842 9.49e-19 85.1 COG0154@1|root,COG0154@2|Bacteria,1MUVQ@1224|Proteobacteria,2VIG3@28216|Betaproteobacteria,1KSIC@119069|Hydrogenophilales 119069|Hydrogenophilales J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) gatA - 6.3.5.6,6.3.5.7 ko:K02433 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - Amidase k59_1189743_1 313596.RB2501_00936 7.34e-56 188.0 COG1457@1|root,COG1457@2|Bacteria,4NHHC@976|Bacteroidetes,1HX92@117743|Flavobacteriia 976|Bacteroidetes F Belongs to the purine-cytosine permease (2.A.39) family - - - - - - - - - - - - - k59_511706_1 765911.Thivi_0061 3.31e-30 125.0 COG0589@1|root,COG0730@1|root,COG0589@2|Bacteria,COG0730@2|Bacteria,1NBKV@1224|Proteobacteria,1SHMY@1236|Gammaproteobacteria 1236|Gammaproteobacteria T Universal stress protein family - - - ko:K07090 - - - - ko00000 - - - TauE,Usp k59_1020610_1 574966.KB898652_gene1784 8.07e-10 65.1 COG0750@1|root,COG0750@2|Bacteria,1MU91@1224|Proteobacteria,1RMIX@1236|Gammaproteobacteria,1XH5P@135619|Oceanospirillales 135619|Oceanospirillales M zinc metalloprotease rseP - - ko:K11749 ko02024,ko04112,map02024,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - PDZ,PDZ_2,Peptidase_M50 k59_907011_1 448385.sce7660 3.3e-106 327.0 COG0018@1|root,COG0018@2|Bacteria,1MU4J@1224|Proteobacteria,42MTY@68525|delta/epsilon subdivisions,2WKII@28221|Deltaproteobacteria,2YU3K@29|Myxococcales 28221|Deltaproteobacteria J Arginyl-tRNA synthetase argS - 6.1.1.19 ko:K01887 ko00970,map00970 M00359,M00360 R03646 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d k59_1302890_1 391587.KAOT1_19437 4.29e-50 171.0 COG1032@1|root,COG1032@2|Bacteria,4NKFV@976|Bacteroidetes,1HXZP@117743|Flavobacteriia 976|Bacteroidetes C COG1032 Fe-S oxidoreductase - - - - - - - - - - - - B12-binding,Radical_SAM k59_1302890_2 1144313.PMI10_02849 8.42e-34 125.0 COG0500@1|root,COG2226@2|Bacteria,4NICK@976|Bacteroidetes,1I0JJ@117743|Flavobacteriia,2NYMB@237|Flavobacterium 976|Bacteroidetes Q Thiopurine S-methyltransferase (TPMT) - - - - - - - - - - - - Methyltransf_25 k59_1415621_1 1144307.PMI04_00182 1.19e-80 254.0 COG1541@1|root,COG1541@2|Bacteria,1NT0G@1224|Proteobacteria,2UP2C@28211|Alphaproteobacteria,2K9AS@204457|Sphingomonadales 204457|Sphingomonadales H Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA) - - - - - - - - - - - - - k59_286041_1 279238.Saro_1888 2.53e-22 98.2 COG1629@1|root,COG1629@2|Bacteria,1MWTT@1224|Proteobacteria,2TURM@28211|Alphaproteobacteria,2K1TV@204457|Sphingomonadales 204457|Sphingomonadales P COG1629 Outer membrane receptor proteins, mostly Fe transport - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - OMP_b-brl_3,Plug,TonB_dep_Rec k59_1076504_1 713586.KB900536_gene91 6.5e-77 248.0 COG0493@1|root,COG1143@1|root,COG0493@2|Bacteria,COG1143@2|Bacteria,1MU2H@1224|Proteobacteria,1RREP@1236|Gammaproteobacteria,1WWDT@135613|Chromatiales 135613|Chromatiales C PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase - - - - - - - - - - - - Fer4_20,Fer4_7,Pyr_redox_2 k59_1076504_2 648757.Rvan_0591 3.26e-10 59.7 2E6CU@1|root,3310G@2|Bacteria,1NBK1@1224|Proteobacteria,2UGBG@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_1189768_1 1279017.AQYJ01000024_gene933 2.98e-35 130.0 2E3UE@1|root,32YRS@2|Bacteria 2|Bacteria S Protein of unknown function (DUF2799) - - - - - - - - - - - - DUF2799 k59_60186_1 1260251.SPISAL_05535 2.01e-88 265.0 COG0479@1|root,COG0479@2|Bacteria,1MVHS@1224|Proteobacteria,1RNWR@1236|Gammaproteobacteria,1WWKQ@135613|Chromatiales 135613|Chromatiales C TIGRFAM succinate dehydrogenase and fumarate reductase iron-sulfur protein sdhB - 1.3.5.1,1.3.5.4 ko:K00240 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00149,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 - - - Fer2_3,Fer4_17,Fer4_8 k59_455348_1 565045.NOR51B_2189 5.51e-09 58.9 COG1262@1|root,COG1262@2|Bacteria,1NQ5K@1224|Proteobacteria,1RQVS@1236|Gammaproteobacteria,1J55S@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Sulfatase-modifying factor enzyme 1 - - - - - - - - - - - - FGE-sulfatase,PEGA k59_455348_2 1415778.JQMM01000001_gene1141 2.87e-25 105.0 COG0457@1|root,COG0457@2|Bacteria,1RC07@1224|Proteobacteria,1S36N@1236|Gammaproteobacteria,1J5XV@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Tetratricopeptide repeat - - - - - - - - - - - - TPR_8 k59_963709_2 1122137.AQXF01000007_gene3537 1.31e-81 246.0 COG0336@1|root,COG0336@2|Bacteria,1MUN1@1224|Proteobacteria,2TSIZ@28211|Alphaproteobacteria 28211|Alphaproteobacteria J Belongs to the RNA methyltransferase TrmD family trmD GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009019,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0016772,GO:0016779,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050518,GO:0070567,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.1.1.228 ko:K00554 - - R00597 RC00003,RC00334 ko00000,ko01000,ko03016 - - - tRNA_m1G_MT k59_286052_1 1088721.NSU_0172 8.64e-136 406.0 COG0642@1|root,COG2205@2|Bacteria,1QVQF@1224|Proteobacteria,2TWX1@28211|Alphaproteobacteria,2KEEV@204457|Sphingomonadales 204457|Sphingomonadales T Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - - - - - - - - - - GAF,HATPase_c k59_963711_1 1121918.ARWE01000001_gene895 1.91e-75 241.0 COG0042@1|root,COG0042@2|Bacteria,1MV5V@1224|Proteobacteria,42N3M@68525|delta/epsilon subdivisions,2WKM7@28221|Deltaproteobacteria,43U4T@69541|Desulfuromonadales 28221|Deltaproteobacteria H Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines nifR3 - - ko:K05540 - - - - ko00000,ko01000,ko03016 - - - Dus k59_963711_2 1303692.SFUL_5744 0.000894 42.4 COG3290@1|root,COG3290@2|Bacteria,2GIRZ@201174|Actinobacteria 201174|Actinobacteria T signal transduction histidine kinase regulating citrate malate metabolism - - 2.7.13.3 ko:K02476 - - - - ko00000,ko01000,ko01001,ko02022 - - - HATPase_c,PAS,SPOB_a,sCache_3_2 k59_1189781_1 1137281.D778_02138 2.12e-97 312.0 COG0243@1|root,COG0437@1|root,COG0243@2|Bacteria,COG0437@2|Bacteria,4NE5M@976|Bacteroidetes,1HWY0@117743|Flavobacteriia 976|Bacteroidetes C Quinol cytochrome c oxidoreductase nrfC - - ko:K00184 - - - - ko00000 5.A.3 - - Fer4_7,Molydop_binding k59_1359341_1 1470591.BW41_00633 4.83e-15 71.2 2FH98@1|root,30ZYW@2|Bacteria,1PMYY@1224|Proteobacteria,2V0JH@28211|Alphaproteobacteria,2KBCB@204457|Sphingomonadales 204457|Sphingomonadales - - - - - - - - - - - - - - - k59_229240_1 1382359.JIAL01000001_gene2776 3.74e-62 199.0 COG3467@1|root,COG3467@2|Bacteria,3Y4HI@57723|Acidobacteria,2JMS6@204432|Acidobacteriia 204432|Acidobacteriia S Pyridoxamine 5'-phosphate oxidase - - - ko:K07005 - - - - ko00000 - - - Pyridox_ox_2 k59_229245_1 1335757.SPICUR_01540 2.82e-77 253.0 COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,1RN3H@1236|Gammaproteobacteria,1WWZ3@135613|Chromatiales 135613|Chromatiales KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance - - 2.7.6.5,3.1.7.2 ko:K01139 ko00230,map00230 - R00336,R00429 RC00002,RC00078 ko00000,ko00001,ko01000,ko03009 - - - ACT_4,HD_4,RelA_SpoT,TGS k59_1302915_1 648757.Rvan_2054 7.62e-58 199.0 COG0419@1|root,COG0419@2|Bacteria,1R8F1@1224|Proteobacteria,2UA7D@28211|Alphaproteobacteria 28211|Alphaproteobacteria L ATPase involved in DNA repair - - - - - - - - - - - - AAA_23 k59_1133260_1 1128427.KB904821_gene1038 4.62e-19 81.6 COG0681@1|root,COG0681@2|Bacteria,1GA6F@1117|Cyanobacteria,1HD6Y@1150|Oscillatoriales 1117|Cyanobacteria U Peptidase S24-like - - - - - - - - - - - - Peptidase_S24 k59_1133260_2 1121918.ARWE01000001_gene3569 5.37e-52 166.0 293MU@1|root,2ZR3M@2|Bacteria,1REEY@1224|Proteobacteria 1224|Proteobacteria S Superoxide dismutase - - 1.15.1.1 ko:K00518 - - - - ko00000,ko01000 - - - Sod_Ni k59_229250_2 557599.MKAN_19080 5.41e-21 93.2 COG1656@1|root,COG1656@2|Bacteria,2GMQR@201174|Actinobacteria,23528@1762|Mycobacteriaceae 201174|Actinobacteria S Mut7-C ubiquitin - - - ko:K09122 - - - - ko00000 - - - Mut7-C,Ub-Mut7C k59_116761_1 655815.ZPR_1840 4.02e-58 201.0 COG2905@1|root,COG2905@2|Bacteria,4NDZ8@976|Bacteroidetes,1HWQU@117743|Flavobacteriia 976|Bacteroidetes T signal-transduction protein containing cAMP-binding and CBS - - - ko:K07182 - - - - ko00000 - - - CBS,DUF294,DUF294_C,cNMP_binding k59_1472303_1 871963.Desdi_0397 1.57e-11 65.5 COG0589@1|root,COG0589@2|Bacteria,1VEJR@1239|Firmicutes,24QQ6@186801|Clostridia,265CG@186807|Peptococcaceae 186801|Clostridia T PFAM Universal stress protein family - - - - - - - - - - - - Usp k59_1472303_2 981336.F944_01306 1.2e-11 63.2 COG0589@1|root,COG0589@2|Bacteria,1MZ3K@1224|Proteobacteria,1SFMR@1236|Gammaproteobacteria,3NNAM@468|Moraxellaceae 1236|Gammaproteobacteria T Universal stress protein family - - - - - - - - - - - - Usp k59_1585169_1 1088721.NSU_1731 2.04e-63 205.0 COG0739@1|root,COG0739@2|Bacteria,1MVTF@1224|Proteobacteria,2TQZE@28211|Alphaproteobacteria,2K148@204457|Sphingomonadales 204457|Sphingomonadales M COG0739 Membrane proteins related to metalloendopeptidases - - - - - - - - - - - - Peptidase_M23 k59_794526_1 401053.AciPR4_1562 5.56e-45 164.0 COG1858@1|root,COG1858@2|Bacteria,3Y58I@57723|Acidobacteria,2JKKG@204432|Acidobacteriia 204432|Acidobacteriia P cytochrome C peroxidase - - - - - - - - - - - - - k59_1641840_1 1122137.AQXF01000003_gene1929 1.1e-83 262.0 COG4942@1|root,COG4942@2|Bacteria,1MY3E@1224|Proteobacteria,2TUSP@28211|Alphaproteobacteria 28211|Alphaproteobacteria D COG4942 Membrane-bound metallopeptidase filA - - - - - - - - - - - Peptidase_M23 k59_398976_1 1172180.KB911797_gene8025 4.09e-22 95.9 COG1960@1|root,COG1960@2|Bacteria,2GK9C@201174|Actinobacteria 201174|Actinobacteria I acyl-CoA dehydrogenase - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_N k59_1133274_1 1229909.NSED_02095 1.93e-56 177.0 COG3439@1|root,arCOG02761@2157|Archaea 2157|Archaea S Domain of unknown function DUF302 - - - - - - - - - - - - DUF302 k59_568479_1 1148.1653946 1.65e-09 66.6 COG0428@1|root,COG0664@1|root,COG0428@2|Bacteria,COG0664@2|Bacteria,1G2YK@1117|Cyanobacteria,1H684@1142|Synechocystis 1117|Cyanobacteria PT Cyclic nucleotide-monophosphate binding domain - - - - - - - - - - - - Zip,cNMP_binding k59_173177_1 1384054.N790_00805 6.54e-08 61.6 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1X3PQ@135614|Xanthomonadales 135614|Xanthomonadales V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family mdtB - - ko:K03296 - - - - ko00000 2.A.6.2 - - ACR_tran k59_286114_1 288000.BBta_6267 5.17e-06 49.3 COG2207@1|root,COG2207@2|Bacteria,1RGAD@1224|Proteobacteria,2U8W3@28211|Alphaproteobacteria,3JZ22@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria K PFAM helix-turn-helix- domain containing protein, AraC type - - - - - - - - - - - - HTH_18,PAS_3 k59_286114_2 1448139.AI20_12715 8.92e-07 50.8 COG2318@1|root,COG2318@2|Bacteria,1RHRP@1224|Proteobacteria,1S2K9@1236|Gammaproteobacteria 1236|Gammaproteobacteria S DinB family - - - - - - - - - - - - DinB k59_624832_1 1077972.ARGLB_037_00760 4.87e-17 86.3 COG0631@1|root,COG0631@2|Bacteria,2GJ3M@201174|Actinobacteria,1W7FE@1268|Micrococcaceae 201174|Actinobacteria T phosphatase pstP GO:0000287,GO:0001932,GO:0001933,GO:0003674,GO:0003824,GO:0004647,GO:0004721,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0006464,GO:0006469,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009892,GO:0009987,GO:0010563,GO:0010605,GO:0016020,GO:0016021,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019220,GO:0019222,GO:0019538,GO:0030145,GO:0030312,GO:0031224,GO:0031226,GO:0031323,GO:0031324,GO:0031399,GO:0031400,GO:0032268,GO:0032269,GO:0033673,GO:0036211,GO:0042325,GO:0042326,GO:0042578,GO:0043085,GO:0043086,GO:0043167,GO:0043169,GO:0043170,GO:0043392,GO:0043412,GO:0043549,GO:0044092,GO:0044093,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0045859,GO:0045936,GO:0046872,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050794,GO:0051098,GO:0051100,GO:0051101,GO:0051171,GO:0051172,GO:0051174,GO:0051246,GO:0051248,GO:0051338,GO:0051348,GO:0060255,GO:0065007,GO:0065009,GO:0071704,GO:0071944,GO:0080090,GO:0140096,GO:1901564 3.1.3.16 ko:K20074 - - - - ko00000,ko01000,ko01009 - - - PP2C,PP2C_2 k59_1076578_1 935567.JAES01000005_gene533 1.03e-79 241.0 COG2096@1|root,COG2096@2|Bacteria,1RDUF@1224|Proteobacteria,1S40D@1236|Gammaproteobacteria,1X50D@135614|Xanthomonadales 135614|Xanthomonadales S adenosyltransferase - - 2.5.1.17 ko:K00798 ko00860,ko01100,map00860,map01100 M00122 R01492,R05220,R07268 RC00533 ko00000,ko00001,ko00002,ko01000 - - - Cob_adeno_trans k59_3408_2 1293047.CBMA010000046_gene2827 0.000763 50.1 COG3299@1|root,arCOG10307@2157|Archaea,2XVGJ@28890|Euryarchaeota,23U2K@183963|Halobacteria 183963|Halobacteria S Baseplate J-like protein - - - - - - - - - - - - Baseplate_J k59_568512_1 1121123.AUAO01000001_gene739 8.03e-139 405.0 COG3866@1|root,COG3866@2|Bacteria,1MUT3@1224|Proteobacteria,2U08U@28211|Alphaproteobacteria,2KI4G@204458|Caulobacterales 204458|Caulobacterales G pectate lyase - - - - - - - - - - - - - k59_399011_1 1122137.AQXF01000006_gene689 4.04e-100 298.0 COG2063@1|root,COG2063@2|Bacteria,1RDEY@1224|Proteobacteria,2TRHN@28211|Alphaproteobacteria 28211|Alphaproteobacteria N Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation flgH - - ko:K02393 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - FlgH k59_455412_1 1127673.GLIP_2700 1.39e-89 292.0 COG1629@1|root,COG1629@2|Bacteria,COG4771@2|Bacteria,1MU9K@1224|Proteobacteria,1RMTG@1236|Gammaproteobacteria 1236|Gammaproteobacteria P Receptor - - - - - - - - - - - - Plug,TonB_dep_Rec k59_116813_1 1528106.JRJE01000020_gene2311 2.39e-06 54.7 COG0642@1|root,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,2TRHH@28211|Alphaproteobacteria,2JPVE@204441|Rhodospirillales 204441|Rhodospirillales T signal transduction histidine kinase - - - - - - - - - - - - CHASE,HATPase_c,HisKA,Hpt,MASE1,Response_reg k59_343859_1 1206730.BAGA01000171_gene2190 1.92e-45 162.0 COG0028@1|root,COG0028@2|Bacteria,2GM6Y@201174|Actinobacteria,4FZBM@85025|Nocardiaceae 201174|Actinobacteria EH Thiamine pyrophosphate enzyme, central domain ilvG - 2.2.1.6,4.1.1.8 ko:K01577,ko:K01652 ko00290,ko00630,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00630,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R01908,R03050,R04672,R04673,R08648 RC00027,RC00106,RC00620,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_1473516_1 1149133.ppKF707_1875 9.83e-108 332.0 COG1032@1|root,COG1032@2|Bacteria,1MUG3@1224|Proteobacteria,1RN9V@1236|Gammaproteobacteria,1YDJE@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria C Domain of unknown function (DUF3362) ygiQ - - - - - - - - - - - DUF3362,Radical_SAM,Radical_SAM_N k59_4671_1 1163407.UU7_14710 4.48e-35 139.0 COG0643@1|root,COG0745@1|root,COG2198@1|root,COG0643@2|Bacteria,COG0745@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,1RMS6@1236|Gammaproteobacteria,1X3AY@135614|Xanthomonadales 135614|Xanthomonadales T Chemotaxis protein histidine kinase and related kinases pilL - - ko:K02487,ko:K06596 ko02020,ko02025,map02020,map02025 M00507 - - ko00000,ko00001,ko00002,ko01001,ko02022,ko02035 - - - CheW,H-kinase_dim,HATPase_c,Hpt,Response_reg k59_512948_1 338969.Rfer_2735 3.8e-05 49.7 COG2204@1|root,COG2204@2|Bacteria,1QZ6X@1224|Proteobacteria 1224|Proteobacteria T response regulator - - - - - - - - - - - - Response_reg k59_456598_1 1415778.JQMM01000001_gene921 2.42e-52 181.0 COG2925@1|root,COG2925@2|Bacteria,1MV0U@1224|Proteobacteria,1RM85@1236|Gammaproteobacteria,1J4T9@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L COG2925 Exonuclease I sbcB GO:0000175,GO:0000287,GO:0000738,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0004518,GO:0004527,GO:0004529,GO:0004532,GO:0004536,GO:0004540,GO:0005488,GO:0006139,GO:0006259,GO:0006308,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008296,GO:0008297,GO:0008310,GO:0008408,GO:0008852,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016796,GO:0016829,GO:0016835,GO:0016895,GO:0016896,GO:0019439,GO:0034641,GO:0034655,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0046872,GO:0051575,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0097159,GO:0140097,GO:0140098,GO:1901360,GO:1901361,GO:1901363,GO:1901575 3.1.11.1 ko:K01141 ko03430,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - Exonuc_X-T_C,RNase_T k59_852143_1 1268303.RHODMAR_1132 9.63e-204 598.0 COG3383@1|root,COG3383@2|Bacteria,2HC9H@201174|Actinobacteria,4G9N0@85025|Nocardiaceae 201174|Actinobacteria C Molydopterin dinucleotide binding domain - - 1.17.1.9 ko:K00123,ko:K00372 ko00630,ko00680,ko00910,ko01100,ko01120,ko01200,map00630,map00680,map00910,map01100,map01120,map01200 M00531 R00519,R00798,R01106 RC02796,RC02812 ko00000,ko00001,ko00002,ko01000 - - - Fer2_4,Fer4,Fer4_9,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3 k59_456601_1 1122137.AQXF01000002_gene35 9.27e-53 172.0 COG0704@1|root,COG0704@2|Bacteria,1MUMI@1224|Proteobacteria,2TQMN@28211|Alphaproteobacteria 28211|Alphaproteobacteria P Plays a role in the regulation of phosphate uptake phoU GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009892,GO:0010563,GO:0010966,GO:0019220,GO:0019222,GO:0031323,GO:0031324,GO:0032879,GO:0034762,GO:0034763,GO:0034765,GO:0034766,GO:0042802,GO:0042803,GO:0043269,GO:0043271,GO:0044070,GO:0044424,GO:0044464,GO:0045936,GO:0046983,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051049,GO:0051051,GO:0051174,GO:0065007,GO:1903792,GO:1903795,GO:1903796,GO:1903959,GO:1903960,GO:2000185,GO:2000186 - ko:K02039 - - - - ko00000 - - - PhoU k59_456601_2 351607.Acel_1449 0.000196 44.3 COG0745@1|root,COG0745@2|Bacteria,2GIZB@201174|Actinobacteria,4ERG0@85013|Frankiales 201174|Actinobacteria T Two component transcriptional regulator, winged helix family - - - ko:K02483 - - - - ko00000,ko02022 - - - Response_reg,Trans_reg_C k59_745680_1 1411123.JQNH01000001_gene772 1.97e-121 355.0 COG3181@1|root,COG3181@2|Bacteria,1MXEX@1224|Proteobacteria,2TT5Y@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Tripartite tricarboxylate transporter family receptor MA20_15115 - - ko:K07795 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.80.1 - - TctC k59_1649759_2 929562.Emtol_4095 6.91e-40 140.0 COG0859@1|root,COG0859@2|Bacteria,4NEPH@976|Bacteroidetes,47MA4@768503|Cytophagia 976|Bacteroidetes M PFAM glycosyl transferase family 9 - - - ko:K02843 ko00540,ko01100,map00540,map01100 M00080 - - ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT9 - Glyco_transf_9 k59_1311039_1 1229780.BN381_180020 2.63e-60 203.0 COG1061@1|root,COG1061@2|Bacteria,2GIU5@201174|Actinobacteria,3UW9B@52018|unclassified Actinobacteria (class) 201174|Actinobacteria L Type III restriction enzyme, res subunit sdrA GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - - - - - - - - - - ResIII k59_1536872_1 742743.HMPREF9453_00635 3.83e-05 45.8 COG0275@1|root,COG0275@2|Bacteria,1TNZV@1239|Firmicutes,4H2T1@909932|Negativicutes 909932|Negativicutes J Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA rsmH - 2.1.1.199 ko:K03438 - - - - ko00000,ko01000,ko03009 - - - Methyltransf_5 k59_1536872_2 305700.B447_02948 4.44e-14 68.6 COG3116@1|root,COG3116@2|Bacteria,1N6WK@1224|Proteobacteria,2VW1W@28216|Betaproteobacteria,2KWVG@206389|Rhodocyclales 206389|Rhodocyclales D Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic ftsL - - ko:K03586 - - - - ko00000,ko03036 - - - FtsL k59_1536872_3 765914.ThisiDRAFT_1099 7.08e-22 97.1 COG0768@1|root,COG0768@2|Bacteria,1MUNY@1224|Proteobacteria,1RNGW@1236|Gammaproteobacteria,1WWDS@135613|Chromatiales 135613|Chromatiales M Catalyzes cross-linking of the peptidoglycan cell wall at the division septum ftsI - 3.4.16.4 ko:K03587 ko00550,ko01501,map00550,map01501 - - - ko00000,ko00001,ko01000,ko01011,ko03036 - - - PBP_dimer,Transpeptidase k59_519454_1 326424.FRAAL5492 1.3e-48 169.0 COG0526@1|root,COG0526@2|Bacteria,2HA4Q@201174|Actinobacteria 201174|Actinobacteria CO Evidence 5 No homology to any previously reported sequences - - - - - - - - - - - - - k59_1762627_1 1122194.AUHU01000003_gene2209 2.91e-54 187.0 COG0661@1|root,COG0661@2|Bacteria,1MU1Z@1224|Proteobacteria,1RNQM@1236|Gammaproteobacteria,463Y4@72275|Alteromonadaceae 1236|Gammaproteobacteria S Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis ubiB GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016020,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:1901576,GO:1901661,GO:1901663 - ko:K03688 - - - - ko00000 - - iYL1228.KPN_04331 ABC1 k59_802678_1 1117314.PCIT_16205 1.26e-81 263.0 COG1228@1|root,COG1228@2|Bacteria,1PFA9@1224|Proteobacteria,1RXWB@1236|Gammaproteobacteria,2Q4XN@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria Q Amidohydrolase family - - - - - - - - - - - - Amidohydro_1 k59_859498_1 702113.PP1Y_AT36210 2.99e-43 157.0 COG2943@1|root,COG2943@2|Bacteria,1MVXZ@1224|Proteobacteria,2TQU8@28211|Alphaproteobacteria,2K06X@204457|Sphingomonadales 204457|Sphingomonadales M PFAM Glycosyl transferase family 2 - - - ko:K03669 - - - - ko00000,ko01000,ko01003,ko02000 4.D.3.1.1 GT2 - Glyco_trans_2_3 k59_463302_1 1219049.SP5_064_00560 7.51e-25 103.0 COG0161@1|root,COG0161@2|Bacteria,1MU2N@1224|Proteobacteria,2TQND@28211|Alphaproteobacteria,2JZX7@204457|Sphingomonadales 204457|Sphingomonadales E Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family - - - - - - - - - - - - Aminotran_3 k59_463302_2 420324.KI911992_gene7723 6.89e-100 295.0 COG1011@1|root,COG1011@2|Bacteria,1NYX7@1224|Proteobacteria,2TVNX@28211|Alphaproteobacteria,1JVQU@119045|Methylobacteriaceae 28211|Alphaproteobacteria S TIGRFAM HAD-superfamily hydrolase, subfamily IA, variant 2 (HAD-like) - - 3.8.1.2 ko:K01560,ko:K07025 ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120 - R05287 RC00697 ko00000,ko00001,ko01000 - - - HAD_2 k59_68553_1 10320.A0A0U2T279_9ALPH 1.58e-06 55.1 4QB40@10239|Viruses,4QV3M@35237|dsDNA viruses no RNA stage,4R1DR@548681|Herpesvirales 548681|Herpesvirales L 3'-5' exonuclease activity - GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004527,GO:0004540,GO:0005575,GO:0006139,GO:0006259,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008409,GO:0009058,GO:0009059,GO:0009987,GO:0016032,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0018130,GO:0018995,GO:0019058,GO:0019079,GO:0019438,GO:0033643,GO:0033646,GO:0033647,GO:0033648,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0039686,GO:0039693,GO:0042025,GO:0042221,GO:0043170,GO:0043656,GO:0043657,GO:0044215,GO:0044216,GO:0044217,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044403,GO:0044419,GO:0046483,GO:0050896,GO:0051704,GO:0071704,GO:0071897,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0090503,GO:0140097,GO:0140098,GO:1901360,GO:1901362,GO:1901576,GO:1902074 - - - - - - - - - - - k59_350838_2 675635.Psed_1889 5.1e-81 252.0 COG0451@1|root,COG0451@2|Bacteria,2I2UT@201174|Actinobacteria,4E1NM@85010|Pseudonocardiales 201174|Actinobacteria M Polysaccharide biosynthesis protein galE1 GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 4.2.1.46,5.1.3.2 ko:K01710,ko:K01784 ko00052,ko00520,ko00521,ko00523,ko00525,ko01055,ko01100,ko01130,map00052,map00520,map00521,map00523,map00525,map01055,map01100,map01130 M00361,M00362,M00632,M00793 R00291,R02984,R06513 RC00289,RC00402 ko00000,ko00001,ko00002,ko01000 - - - Epimerase,GDP_Man_Dehyd k59_802690_1 1121897.AUGO01000003_gene1831 8.91e-99 304.0 COG3104@1|root,COG3104@2|Bacteria,4NE8R@976|Bacteroidetes,1HWTF@117743|Flavobacteriia,2NV5A@237|Flavobacterium 976|Bacteroidetes E amino acid - - - ko:K03305 - - - - ko00000 2.A.17 - - PTR2 k59_1254421_1 1274524.BSONL12_18559 2.56e-20 94.0 COG1807@1|root,COG1807@2|Bacteria,1TPGI@1239|Firmicutes,4HCEY@91061|Bacilli,1ZCFV@1386|Bacillus 91061|Bacilli M COG1807 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family ykcB - - - - - - - - - - - PMT_2 k59_1311072_1 1123279.ATUS01000001_gene1423 2.11e-51 171.0 COG1305@1|root,COG1305@2|Bacteria,1MVAG@1224|Proteobacteria,1RMXM@1236|Gammaproteobacteria,1J91J@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Bacterial transglutaminase-like N-terminal region - - - - - - - - - - - - Bact_transglu_N,Transglut_core k59_294410_1 998674.ATTE01000001_gene302 2.64e-48 165.0 COG0019@1|root,COG0019@2|Bacteria,1MUA6@1224|Proteobacteria,1RMI2@1236|Gammaproteobacteria,4605P@72273|Thiotrichales 72273|Thiotrichales E Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine lysA - 4.1.1.20 ko:K01586 ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R00451 RC00299 ko00000,ko00001,ko00002,ko01000 - - - Orn_Arg_deC_N,Orn_DAP_Arg_deC k59_294410_3 1163409.UUA_13285 3.19e-10 59.3 COG0400@1|root,COG0400@2|Bacteria,1RA02@1224|Proteobacteria,1S24F@1236|Gammaproteobacteria,1X4YF@135614|Xanthomonadales 135614|Xanthomonadales S Carboxylesterase - - - ko:K06999 - - - - ko00000 - - - Abhydrolase_2 k59_68574_1 1137281.D778_00587 3.28e-90 274.0 COG1195@1|root,COG1195@2|Bacteria,4NFHN@976|Bacteroidetes,1HX8P@117743|Flavobacteriia 976|Bacteroidetes L it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP recF GO:0000731,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0018130,GO:0019438,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:1901360,GO:1901362,GO:1901576 - ko:K03629 ko03440,map03440 - - - ko00000,ko00001,ko03400 - - - AAA_15,SMC_N k59_294411_1 497321.C664_02890 1.4e-20 92.8 COG0664@1|root,COG0664@2|Bacteria,1MXID@1224|Proteobacteria,2VKF3@28216|Betaproteobacteria,2KVQ8@206389|Rhodocyclales 206389|Rhodocyclales K COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases crp - - ko:K10914 ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111 - - - ko00000,ko00001,ko03000 - - - HTH_Crp_2,cNMP_binding k59_294414_2 882086.SacxiDRAFT_4005 4.85e-17 81.3 COG1938@1|root,COG1938@2|Bacteria,2GK10@201174|Actinobacteria,4EFA9@85010|Pseudonocardiales 201174|Actinobacteria S ATP-grasp superfamily - - - - - - - - - - - - PAC2 k59_350873_1 876269.ARWA01000001_gene2920 2.62e-35 125.0 COG4319@1|root,COG4319@2|Bacteria,1RII1@1224|Proteobacteria,2UDKT@28211|Alphaproteobacteria 28211|Alphaproteobacteria S SnoaL-like domain - - - - - - - - - - - - DUF4440 k59_1649818_2 436308.Nmar_0007 1.68e-221 627.0 COG0652@1|root,arCOG04767@2157|Archaea,41T0W@651137|Thaumarchaeota 651137|Thaumarchaeota O Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD - - 5.2.1.8 ko:K03768 - - - - ko00000,ko01000,ko03110 - - - Pro_isomerase k59_576268_1 1415778.JQMM01000001_gene1456 3.5e-23 95.5 COG0078@1|root,COG0078@2|Bacteria,1MUFM@1224|Proteobacteria,1RQ59@1236|Gammaproteobacteria,1J4QF@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline argF - 2.1.3.3,2.1.3.6,2.1.3.9 ko:K00611,ko:K09065,ko:K13252 ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230 M00029,M00844,M00845 R01398,R07245 RC00096 ko00000,ko00001,ko00002,ko01000 - - - OTCace,OTCace_N k59_576268_2 1173022.Cri9333_4527 4.51e-10 65.9 COG1842@1|root,COG1842@2|Bacteria 2|Bacteria KT Phage shock protein A pspA GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - ko:K03969 - - - - ko00000 - - - DUF4139,DUF4140,LRAT,PspA_IM30 k59_1367676_2 436308.Nmar_1741 5.1e-52 176.0 arCOG08768@1|root,arCOG08768@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_1481036_1 1382306.JNIM01000001_gene1312 2.59e-21 94.7 COG5427@1|root,COG5427@2|Bacteria,2G6AA@200795|Chloroflexi 200795|Chloroflexi S Uncharacterized membrane protein (DUF2298) - - - - - - - - - - - - DUF2298 k59_1536944_1 402626.Rpic_4782 4.1e-21 95.1 COG1256@1|root,COG1256@2|Bacteria,1MV2M@1224|Proteobacteria,2VH02@28216|Betaproteobacteria,1K3R9@119060|Burkholderiaceae 28216|Betaproteobacteria N flagellar hook-associated protein flgK - - ko:K02396 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - Flg_bb_rod,Flg_bbr_C k59_1536944_2 1122197.ATWI01000009_gene1724 7.84e-26 107.0 COG1344@1|root,COG1344@2|Bacteria,1PJUJ@1224|Proteobacteria,1RPNR@1236|Gammaproteobacteria,466JS@72275|Alteromonadaceae 1236|Gammaproteobacteria N Belongs to the bacterial flagellin family flgL - - ko:K02397 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - Flagellin_C,Flagellin_N k59_68605_1 471852.Tcur_3818 5.16e-11 67.4 COG1020@1|root,COG1020@2|Bacteria,2GKGU@201174|Actinobacteria,4EGUM@85012|Streptosporangiales 201174|Actinobacteria Q Wax ester synthase-like Acyl-CoA acyltransferase domain - - - - - - - - - - - - DUF1298,WES_acyltransf k59_463338_1 436308.Nmar_0886 8.38e-171 491.0 COG0129@1|root,arCOG04045@2157|Archaea,41SD0@651137|Thaumarchaeota 651137|Thaumarchaeota E Belongs to the IlvD Edd family ilvD - 4.2.1.9 ko:K01687 ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R01209,R04441,R05070 RC00468,RC01714 ko00000,ko00001,ko00002,ko01000 - - - ILVD_EDD k59_1481044_1 395493.BegalDRAFT_2631 5.79e-23 93.2 COG0716@1|root,COG0716@2|Bacteria,1MX7F@1224|Proteobacteria,1RMNT@1236|Gammaproteobacteria,4611D@72273|Thiotrichales 72273|Thiotrichales C Low-potential electron donor to a number of redox enzymes - - - ko:K03839,ko:K03840 - - - - ko00000 - - - Flavodoxin_1 k59_1481044_2 765913.ThidrDRAFT_2076 2.96e-47 163.0 COG0247@1|root,COG0247@2|Bacteria,1QV1F@1224|Proteobacteria,1T3FB@1236|Gammaproteobacteria,1X2VQ@135613|Chromatiales 135613|Chromatiales C 4Fe-4S dicluster domain - - - - - - - - - - - - Fer4_8 k59_1367685_1 1278078.G419_25809 1.56e-50 176.0 COG2124@1|root,COG2124@2|Bacteria,2GNZS@201174|Actinobacteria,4FVYT@85025|Nocardiaceae 201174|Actinobacteria Q Cytochrome P450 - - - - - - - - - - - - p450 k59_859571_1 715226.ABI_30240 2.34e-106 324.0 COG0665@1|root,COG0665@2|Bacteria,1MU40@1224|Proteobacteria 1224|Proteobacteria E Tryptophan halogenase - - 1.14.19.9 ko:K14266 ko00404,ko01130,map00404,map01130 M00789,M00790 R09570 RC00949 ko00000,ko00001,ko00002,ko01000 - - - Trp_halogenase k59_124757_1 330214.NIDE3755 7.8e-70 235.0 COG3696@1|root,COG3696@2|Bacteria 2|Bacteria P silver ion transport - - - ko:K15726 - - - - ko00000,ko02000 2.A.6.1.2 - - ACR_tran k59_1536961_1 1229909.NSED_01805 1.87e-135 409.0 COG0013@1|root,arCOG01255@2157|Archaea,41SBJ@651137|Thaumarchaeota 651137|Thaumarchaeota J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain alaS - 6.1.1.7 ko:K01872 ko00970,map00970 M00359,M00360 R03038 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DHHA1,tRNA-synt_2c,tRNA_SAD k59_68637_1 1266925.JHVX01000005_gene1933 1.68e-53 181.0 COG0056@1|root,COG0056@2|Bacteria,1MUG7@1224|Proteobacteria,2VHQU@28216|Betaproteobacteria,371UU@32003|Nitrosomonadales 28216|Betaproteobacteria F Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit atpA - 3.6.3.14 ko:K02111 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - - ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N k59_68637_2 765914.ThisiDRAFT_2275 2.61e-15 73.2 COG0712@1|root,COG0712@2|Bacteria,1MVRH@1224|Proteobacteria,1S8X2@1236|Gammaproteobacteria,1WY1N@135613|Chromatiales 135613|Chromatiales C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation atpH - - ko:K02113 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - OSCP k59_1197855_1 1123274.KB899431_gene3256 1.59e-76 249.0 COG1080@1|root,COG1080@2|Bacteria,2J5FB@203691|Spirochaetes 203691|Spirochaetes G General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) ptsI - 2.7.3.9 ko:K08483 ko02060,map02060 - - - ko00000,ko00001,ko01000,ko02000 8.A.7 - - PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C k59_1197855_2 448385.sce7312 5.5e-50 171.0 COG0192@1|root,COG0192@2|Bacteria,1MUFQ@1224|Proteobacteria,42MFM@68525|delta/epsilon subdivisions,2WIQ3@28221|Deltaproteobacteria,2YUBT@29|Myxococcales 28221|Deltaproteobacteria H Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme metK GO:0003674,GO:0003824,GO:0004478,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016740,GO:0016765,GO:0044424,GO:0044444,GO:0044464 2.5.1.6 ko:K00789 ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230 M00034,M00035,M00368,M00609 R00177,R04771 RC00021,RC01211 ko00000,ko00001,ko00002,ko01000 - - - S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N k59_1141151_1 323261.Noc_2720 3.74e-63 219.0 COG3391@1|root,COG3391@2|Bacteria,1R66T@1224|Proteobacteria,1S06K@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Protein conserved in bacteria - - - - - - - - - - - - - k59_124775_1 1127673.GLIP_2909 5.35e-121 367.0 COG3808@1|root,COG3808@2|Bacteria,1MUQ3@1224|Proteobacteria,1RN4K@1236|Gammaproteobacteria,469CU@72275|Alteromonadaceae 1236|Gammaproteobacteria C Inorganic H+ pyrophosphatase hppA - 3.6.1.1 ko:K15987 ko00190,map00190 - - - ko00000,ko00001,ko01000 3.A.10.1 - - H_PPase k59_576312_1 199310.c0990 1.51e-115 336.0 COG1177@1|root,COG1177@2|Bacteria,1MVC5@1224|Proteobacteria,1RQB7@1236|Gammaproteobacteria,3XPAQ@561|Escherichia 1236|Gammaproteobacteria P Required for the activity of the bacterial periplasmic transport system of putrescine potI GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0015695,GO:0015696,GO:0015846,GO:0015847,GO:0016020,GO:0016021,GO:0031224,GO:0032991,GO:0043190,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944,GO:0098533,GO:0098796,GO:0098797,GO:1902494,GO:1902495,GO:1904949,GO:1990351 - ko:K11070,ko:K11074 ko02010,map02010 M00299,M00300 - - ko00000,ko00001,ko00002,ko02000 3.A.1.11.1,3.A.1.11.2 - iG2583_1286.G2583_1088,iSBO_1134.SBO_1939,ic_1306.c0990 BPD_transp_1 k59_1312337_1 269799.Gmet_2565 1.55e-52 177.0 COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,42WT2@68525|delta/epsilon subdivisions,2WR9X@28221|Deltaproteobacteria 28221|Deltaproteobacteria L transposase IS116 IS110 IS902 family protein - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_464279_1 1122137.AQXF01000002_gene29 4e-43 150.0 COG0726@1|root,COG0726@2|Bacteria,1MWMZ@1224|Proteobacteria,2TVFK@28211|Alphaproteobacteria 28211|Alphaproteobacteria G Polysaccharide deacetylase - - - - - - - - - - - - DUF3473,Polysacc_deac_1 k59_464279_2 29581.BW37_01048 6.29e-20 90.1 COG2348@1|root,COG2348@2|Bacteria,1MXFY@1224|Proteobacteria,2VNEW@28216|Betaproteobacteria,475EC@75682|Oxalobacteraceae 28216|Betaproteobacteria V Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_6 k59_1142105_2 1123508.JH636439_gene1604 1.15e-17 79.7 29XN2@1|root,30JDF@2|Bacteria,2J498@203682|Planctomycetes 203682|Planctomycetes - - - - - - - - - - - - - - - k59_1142106_1 1449076.JOOE01000002_gene763 1.28e-68 223.0 COG0620@1|root,COG0620@2|Bacteria,1MV2Z@1224|Proteobacteria,2TSRH@28211|Alphaproteobacteria,2K9SZ@204457|Sphingomonadales 204457|Sphingomonadales E Cobalamin-independent synthase, Catalytic domain - - 2.1.1.14 ko:K00549 ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230 M00017 R04405,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 - - - Meth_synt_2 k59_1198810_1 1232437.KL662002_gene4666 1.99e-54 177.0 COG0176@1|root,COG0176@2|Bacteria,1MWQ8@1224|Proteobacteria,42M39@68525|delta/epsilon subdivisions,2WJEZ@28221|Deltaproteobacteria,2MI50@213118|Desulfobacterales 28221|Deltaproteobacteria F Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway tal - 2.2.1.2 ko:K00616 ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007 R01827 RC00439,RC00604 ko00000,ko00001,ko00002,ko01000 - - - TAL_FSA k59_295498_1 1123037.AUDE01000001_gene1824 3.04e-77 258.0 COG1404@1|root,COG3227@1|root,COG3291@1|root,COG4733@1|root,COG4935@1|root,COG1404@2|Bacteria,COG3227@2|Bacteria,COG3291@2|Bacteria,COG4733@2|Bacteria,COG4935@2|Bacteria,4NF8H@976|Bacteroidetes,1IJ61@117743|Flavobacteriia 976|Bacteroidetes E Thermolysin metallopeptidase, catalytic domain - - - - - - - - - - - - DUF5011,MAM,Peptidase_M14,Peptidase_M43,Reprolysin_4,fn3 k59_1594243_1 1280944.HY17_00115 1.41e-16 75.1 COG1359@1|root,COG1359@2|Bacteria,1N8V7@1224|Proteobacteria,2UFYD@28211|Alphaproteobacteria,43YKB@69657|Hyphomonadaceae 28211|Alphaproteobacteria S Antibiotic biosynthesis monooxygenase - - - - - - - - - - - - ABM k59_1763748_1 1094466.KQS_12090 6.62e-213 590.0 COG0208@1|root,COG0208@2|Bacteria,4NG18@976|Bacteroidetes,1HXA5@117743|Flavobacteriia,2NSCG@237|Flavobacterium 976|Bacteroidetes F reductase nrdB - 1.17.4.1 ko:K00526 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - Ribonuc_red_sm k59_1482210_1 1229909.NSED_09165 1.48e-131 384.0 COG0452@1|root,arCOG01704@2157|Archaea,41SYG@651137|Thaumarchaeota 651137|Thaumarchaeota H Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine - - 4.1.1.36,6.3.2.5 ko:K13038 ko00770,ko01100,map00770,map01100 M00120 R03269,R04231 RC00064,RC00090,RC00822 ko00000,ko00001,ko00002,ko01000 - - - DFP,Flavoprotein k59_1482210_2 436308.Nmar_1720 4.16e-162 458.0 COG0413@1|root,arCOG00584@2157|Archaea,41SZX@651137|Thaumarchaeota 651137|Thaumarchaeota H Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate panB - 2.1.2.11 ko:K00606 ko00770,ko01100,ko01110,map00770,map01100,map01110 M00119 R01226 RC00022,RC00200 ko00000,ko00001,ko00002,ko01000 - - - Pantoate_transf k59_1085521_1 877455.Metbo_2230 9.25e-14 77.0 COG0172@1|root,arCOG00403@2157|Archaea,2XTGA@28890|Euryarchaeota,23NQ1@183925|Methanobacteria 183925|Methanobacteria J Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) serS - 6.1.1.11 ko:K01875 ko00970,map00970 M00359,M00360 R03662,R08218 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Seryl_tRNA_N,tRNA-synt_2b k59_1594256_1 521674.Plim_2905 7.35e-23 102.0 COG0657@1|root,COG0657@2|Bacteria,2IZ4H@203682|Planctomycetes 203682|Planctomycetes G COG0657 Esterase lipase - - 3.2.1.8 ko:K01181 - - - - ko00000,ko01000 - - - Abhydrolase_3,Peptidase_S9 k59_238088_1 1123237.Salmuc_02665 1.16e-135 410.0 COG0243@1|root,COG0243@2|Bacteria,1NR6J@1224|Proteobacteria,2TSAP@28211|Alphaproteobacteria 28211|Alphaproteobacteria C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - - - - - - - - - - - Molybdopterin,Molydop_binding k59_746494_1 316407.85674935 7.22e-144 409.0 COG2207@1|root,COG2207@2|Bacteria,1QUXX@1224|Proteobacteria,1RSPT@1236|Gammaproteobacteria 1236|Gammaproteobacteria K transcriptional regulator feaR GO:0000976,GO:0000984,GO:0000986,GO:0000987,GO:0001017,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0003824,GO:0005488,GO:0006081,GO:0006082,GO:0006089,GO:0006355,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009438,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0019172,GO:0019219,GO:0019222,GO:0019243,GO:0019249,GO:0019752,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032787,GO:0042180,GO:0042182,GO:0043436,GO:0043565,GO:0044212,GO:0044237,GO:0044248,GO:0044249,GO:0044281,GO:0044282,GO:0044283,GO:0045893,GO:0045935,GO:0046185,GO:0046394,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051596,GO:0060255,GO:0061727,GO:0065007,GO:0071704,GO:0072330,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1901575,GO:1901576,GO:1901615,GO:1901617,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2001141 - ko:K14063 - - - - ko00000,ko03000 - - - AraC_binding_2,HTH_18 k59_1763767_1 1297742.A176_07349 1.7e-82 258.0 COG0451@1|root,COG0451@2|Bacteria,1MW32@1224|Proteobacteria,42NJT@68525|delta/epsilon subdivisions,2WM7E@28221|Deltaproteobacteria,2YXN2@29|Myxococcales 28221|Deltaproteobacteria GM epimerase dehydratase dfrA - 1.1.1.219 ko:K00091 - - - - ko00000,ko01000 - - - 3Beta_HSD,Epimerase k59_633734_1 477184.KYC_09095 2.02e-110 332.0 COG1008@1|root,COG1008@2|Bacteria,1MV7V@1224|Proteobacteria,2VIAX@28216|Betaproteobacteria,3T1PC@506|Alcaligenaceae 28216|Betaproteobacteria C Catalyzes the transfer of electrons from NADH to quinone nuoM - 1.6.5.3 ko:K00342 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q5_N,Proton_antipo_M k59_1142128_1 472759.Nhal_3009 6.82e-43 145.0 COG2927@1|root,COG2927@2|Bacteria,1MZ3V@1224|Proteobacteria,1S94K@1236|Gammaproteobacteria,1WYQ1@135613|Chromatiales 135613|Chromatiales L DNA polymerase III, chi subunit - - 2.7.7.7 ko:K02339 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_chi k59_1142128_2 1122194.AUHU01000005_gene808 4.55e-11 62.4 COG0525@1|root,COG0525@2|Bacteria,1MV7B@1224|Proteobacteria,1RNEB@1236|Gammaproteobacteria,465F9@72275|Alteromonadaceae 1236|Gammaproteobacteria J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner valS GO:0000287,GO:0002161,GO:0003674,GO:0003824,GO:0004812,GO:0004832,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006417,GO:0006418,GO:0006438,GO:0006450,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0016070,GO:0016787,GO:0016788,GO:0016874,GO:0016875,GO:0019222,GO:0019538,GO:0019752,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0034248,GO:0034250,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045727,GO:0045903,GO:0046483,GO:0046872,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0052689,GO:0060255,GO:0061475,GO:0065007,GO:0065008,GO:0071704,GO:0080090,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:2000112 6.1.1.9 ko:K01873 ko00970,map00970 M00359,M00360 R03665 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iECH74115_1262.ECH74115_5779,iECNA114_1301.ECNA114_4481,iECO26_1355.ECO26_5428,iECSP_1301.ECSP_5359,iECs_1301.ECs5235,iG2583_1286.G2583_5088,iJN746.PP_0977,iSBO_1134.SBO_4182,iSSON_1240.SSON_4443,iYL1228.KPN_04663,iZ_1308.Z5870 Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1 k59_1651031_1 436308.Nmar_0551 5.04e-14 69.7 COG0169@1|root,arCOG02097@2157|Archaea,41SKU@651137|Thaumarchaeota 651137|Thaumarchaeota E Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3- dehydroshikimate aroD - 4.2.1.10 ko:K03785 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R03084 RC00848 ko00000,ko00001,ko00002,ko01000 - - - DHquinase_I k59_1651031_2 1229909.NSED_02800 2.98e-146 419.0 COG1465@1|root,arCOG04353@2157|Archaea,41S88@651137|Thaumarchaeota 651137|Thaumarchaeota E Catalyzes the oxidative deamination and cyclization of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3- dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis aroB' - 1.4.1.24 ko:K11646 ko00400,ko01110,ko01130,map00400,map01110,map01130 - R08569 RC02302 ko00000,ko00001,ko01000 - - - DHQS k59_577448_1 1202962.KB907150_gene1647 4.74e-67 221.0 COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,1RMQ4@1236|Gammaproteobacteria 1236|Gammaproteobacteria IQ COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II rpfB - 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding,AMP-binding_C k59_1604270_2 1122137.AQXF01000002_gene344 2.88e-28 108.0 COG1664@1|root,COG1664@2|Bacteria,1MZN0@1224|Proteobacteria,2U5DW@28211|Alphaproteobacteria 28211|Alphaproteobacteria M Integral membrane protein CcmA involved in cell shape determination - - - - - - - - - - - - Bactofilin k59_1604270_3 28229.ND2E_3130 6.98e-41 143.0 COG1752@1|root,COG1752@2|Bacteria,1MUM9@1224|Proteobacteria,1RRA1@1236|Gammaproteobacteria,2Q80A@267889|Colwelliaceae 1236|Gammaproteobacteria S Patatin-like phospholipase rssA GO:0003674,GO:0003824,GO:0016787 - ko:K07001 - - - - ko00000 - - - Patatin k59_1491869_1 1216007.AOPM01000114_gene282 6.82e-34 134.0 COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MU0R@1224|Proteobacteria,1RP3T@1236|Gammaproteobacteria,2Q104@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria H Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate ppsA GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006094,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008986,GO:0009058,GO:0009987,GO:0016051,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016781,GO:0019318,GO:0019319,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046364,GO:0046872,GO:0071704,GO:1901576 2.7.9.2 ko:K01007 ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200 M00173,M00374 R00199 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - iEcE24377_1341.EcE24377A_1919,iYL1228.KPN_02160 PEP-utilizers,PEP-utilizers_C,PPDK_N k59_642870_1 1229909.NSED_00380 5.21e-52 169.0 COG0406@1|root,arCOG01991@2157|Archaea,41SJM@651137|Thaumarchaeota 651137|Thaumarchaeota G Phosphoglycerate mutase family - - 5.4.2.12 ko:K15634 ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003 R01518 RC00536 ko00000,ko00001,ko00002,ko01000 - - - His_Phos_1 k59_642870_2 1131266.ARWQ01000003_gene1514 9.85e-26 100.0 COG2085@1|root,arCOG00457@2157|Archaea,41SH2@651137|Thaumarchaeota 651137|Thaumarchaeota S PFAM NADP oxidoreductase coenzyme F420-dependent - - 1.5.1.40 ko:K06988 - - - - ko00000,ko01000 - - - F420_oxidored k59_529008_1 1123228.AUIH01000001_gene1413 1.24e-37 135.0 COG0730@1|root,COG0730@2|Bacteria,1MVY3@1224|Proteobacteria,1S21M@1236|Gammaproteobacteria,1XK5F@135619|Oceanospirillales 135619|Oceanospirillales S membrane transporter protein - - - ko:K07090 - - - - ko00000 - - - TauE k59_1491873_1 1121935.AQXX01000068_gene5870 8.67e-07 51.6 COG0029@1|root,COG0029@2|Bacteria,1RBQW@1224|Proteobacteria,1RMMD@1236|Gammaproteobacteria,1XH52@135619|Oceanospirillales 135619|Oceanospirillales H Catalyzes the oxidation of L-aspartate to iminoaspartate nadB - 1.4.3.16 ko:K00278 ko00250,ko00760,ko01100,map00250,map00760,map01100 M00115 R00357,R00481 RC00006,RC02566 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,Succ_DH_flav_C k59_1491873_2 215803.DB30_6050 4.04e-22 97.4 COG1596@1|root,COG1596@2|Bacteria,1N7GP@1224|Proteobacteria,42MNP@68525|delta/epsilon subdivisions,2WMJZ@28221|Deltaproteobacteria,2YVBP@29|Myxococcales 28221|Deltaproteobacteria M polysaccharide export wza2 - - ko:K01991 ko02026,map02026 - - - ko00000,ko00001,ko02000 1.B.18 - - Poly_export,SLBB k59_586988_1 436308.Nmar_0348 1.33e-113 358.0 COG0086@1|root,arCOG04256@2157|Archaea,arCOG04257@2157|Archaea,41SB2@651137|Thaumarchaeota 651137|Thaumarchaeota K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoA2 - 2.7.7.6 ko:K03041 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00184 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021 - - - RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5 k59_870614_1 1122604.JONR01000028_gene3493 1.09e-51 170.0 COG0500@1|root,COG2226@2|Bacteria,1RANW@1224|Proteobacteria,1S1F0@1236|Gammaproteobacteria,1X5TS@135614|Xanthomonadales 135614|Xanthomonadales Q ubiE/COQ5 methyltransferase family - - - - - - - - - - - - Methyltransf_23 k59_1208643_1 1121921.KB898719_gene69 3.61e-25 103.0 COG0086@1|root,COG0086@2|Bacteria,1MU3M@1224|Proteobacteria,1RPYH@1236|Gammaproteobacteria,2PMT9@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria K RNA polymerase I subunit A N-terminus rpoC GO:0000428,GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0030880,GO:0032774,GO:0032991,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234 2.7.7.6 ko:K03046 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5 k59_1208643_2 1415778.JQMM01000001_gene398 4.37e-58 199.0 COG0085@1|root,COG0085@2|Bacteria,1MUC4@1224|Proteobacteria,1RMK0@1236|Gammaproteobacteria,1J52Z@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoB GO:0000428,GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0030880,GO:0032774,GO:0032991,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234 2.7.7.6 ko:K03043 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7 k59_247870_1 338969.Rfer_3358 8e-09 62.0 COG1075@1|root,COG1075@2|Bacteria,1NB6J@1224|Proteobacteria,2VJTN@28216|Betaproteobacteria,4ABWK@80864|Comamonadaceae 28216|Betaproteobacteria S Alpha beta hydrolase fold lip - 3.1.1.3 ko:K01046 ko00561,ko01100,map00561,map01100 M00098 R02250,R02687 RC00020,RC00037,RC00041,RC00094 ko00000,ko00001,ko00002,ko01000 - - - Abhydrolase_1 k59_79846_3 316407.85676552 9.93e-18 80.9 COG2081@1|root,COG2081@2|Bacteria,1MUGC@1224|Proteobacteria,1RNCW@1236|Gammaproteobacteria,3XMPE@561|Escherichia 1236|Gammaproteobacteria S HI0933-like protein yhiN GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - ko:K07007 - - - - ko00000 - - - HI0933_like k59_1040371_1 710687.KI912270_gene1414 8.58e-36 139.0 COG2072@1|root,COG2124@1|root,COG2072@2|Bacteria,COG2124@2|Bacteria,2GMD5@201174|Actinobacteria,232CF@1762|Mycobacteriaceae 201174|Actinobacteria P flavoprotein involved in K transport - - 1.14.13.22 ko:K03379 ko00930,ko01120,ko01220,map00930,map01120,map01220 - R02231,R06622 RC00662,RC01550 ko00000,ko00001,ko01000 - - - Pyr_redox_3 k59_1208649_1 1144307.PMI04_02175 1.68e-169 485.0 COG4638@1|root,COG4638@2|Bacteria,1MWXW@1224|Proteobacteria 1224|Proteobacteria P phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases large terminal subunit - - - - - - - - - - - - Rieske,Ring_hydroxyl_A k59_1378761_1 762376.AXYL_06716 1.96e-83 265.0 COG1053@1|root,COG1053@2|Bacteria,1MURY@1224|Proteobacteria,2VJYH@28216|Betaproteobacteria 28216|Betaproteobacteria C Fumarate reduCtase - - - - - - - - - - - - FAD_binding_2 k59_587010_1 1288484.APCS01000124_gene491 3.79e-36 132.0 COG2896@1|root,COG2896@2|Bacteria,1WIGS@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus H Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate moaA - 4.1.99.22 ko:K03639 ko00790,ko01100,ko04122,map00790,map01100,map04122 - R09394 RC03420 ko00000,ko00001,ko01000 - - - Fer4_12,Mob_synth_C,Radical_SAM k59_587010_2 1169161.KB897720_gene3817 3.92e-09 58.9 COG0846@1|root,COG0846@2|Bacteria,2GJI3@201174|Actinobacteria 201174|Actinobacteria K NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form cobB2 - - ko:K12410 - - - - ko00000,ko01000 - - - SIR2 k59_473293_1 1254432.SCE1572_48650 2.26e-20 96.3 COG3209@1|root,COG3209@2|Bacteria,1MVV1@1224|Proteobacteria,42P9N@68525|delta/epsilon subdivisions,2WJSQ@28221|Deltaproteobacteria 28221|Deltaproteobacteria M Rhs family - - - - - - - - - - - - AHH,RHS_repeat,SpvB,TcdB_toxin_midN,VCBS k59_587015_1 1282360.ABAC460_13040 9.21e-57 187.0 COG2124@1|root,COG2124@2|Bacteria,1MY5H@1224|Proteobacteria,2TR6X@28211|Alphaproteobacteria,2KK09@204458|Caulobacterales 204458|Caulobacterales C Cytochrome P450 - - - - - - - - - - - - p450 k59_587015_2 1282360.ABAC460_13055 1.41e-56 189.0 COG2843@1|root,COG2843@2|Bacteria,1P1MG@1224|Proteobacteria,2TV4X@28211|Alphaproteobacteria,2KJQJ@204458|Caulobacterales 28211|Alphaproteobacteria M Capsule synthesis protein - - - ko:K07282 - - - - ko00000 - - - PGA_cap k59_1040392_1 1187851.A33M_0090 1.46e-136 396.0 COG1638@1|root,COG1638@2|Bacteria,1PJG1@1224|Proteobacteria,2V8IQ@28211|Alphaproteobacteria,3FEKB@34008|Rhodovulum 28211|Alphaproteobacteria G Bacterial extracellular solute-binding protein, family 7 - - - - - - - - - - - - DctP k59_417527_1 203122.Sde_2882 7.91e-115 360.0 COG1629@1|root,COG4771@2|Bacteria,1MXSN@1224|Proteobacteria,1RZC0@1236|Gammaproteobacteria,469HA@72275|Alteromonadaceae 1236|Gammaproteobacteria P TonB dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_700231_1 381666.H16_B1129 2.74e-52 182.0 COG5476@1|root,COG5476@2|Bacteria,1MX4P@1224|Proteobacteria,2VJ0J@28216|Betaproteobacteria,1K48A@119060|Burkholderiaceae 28216|Betaproteobacteria E Involved in peptidolytic degradation of cyclic heptapeptide hepatotoxin microcystin (MC) - - - - - - - - - - - - DUF1485,MlrC_C k59_1548175_1 765914.ThisiDRAFT_1281 6.45e-149 437.0 COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,1RMBS@1236|Gammaproteobacteria,1WXAR@135613|Chromatiales 135613|Chromatiales NU TIGRFAM type IV-A pilus assembly ATPase PilB - - - ko:K02652 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE,T2SSE_N k59_700233_1 366602.Caul_2430 1.24e-136 409.0 COG1022@1|root,COG1022@2|Bacteria,1MU4D@1224|Proteobacteria,2U48I@28211|Alphaproteobacteria 28211|Alphaproteobacteria I AMP-dependent synthetase and ligase - - - - - - - - - - - - AMP-binding,Haem_oxygenas_2 k59_191526_1 1122612.AUBA01000015_gene888 1.38e-44 158.0 COG0277@1|root,COG0277@2|Bacteria,1MY08@1224|Proteobacteria,2U5D5@28211|Alphaproteobacteria,2K1C7@204457|Sphingomonadales 204457|Sphingomonadales C Protein involved in UDP-N-acetylmuramate dehydrogenase activity and amino sugar metabolic process - - 1.17.99.1 ko:K05797 ko00623,ko01100,ko01120,map00623,map01100,map01120 - R02675,R11194 RC00769 ko00000,ko00001,ko01000 - - - FAD-oxidase_C,FAD_binding_4 k59_1321250_1 436308.Nmar_1398 4.93e-118 356.0 COG3593@1|root,arCOG03235@2157|Archaea,41SZV@651137|Thaumarchaeota 651137|Thaumarchaeota L AAA ATPase domain - - - - - - - - - - - - AAA_15 k59_1094926_1 436308.Nmar_1231 6.15e-119 359.0 COG3808@1|root,arCOG04949@2157|Archaea,41SZG@651137|Thaumarchaeota 651137|Thaumarchaeota C Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force hppA - 3.6.1.1 ko:K15987 ko00190,map00190 - - - ko00000,ko00001,ko01000 3.A.10.1 - - H_PPase k59_700236_1 396588.Tgr7_0827 5.6e-65 211.0 COG0329@1|root,COG0329@2|Bacteria,1MUCM@1224|Proteobacteria,1RNH9@1236|Gammaproteobacteria,1WWMV@135613|Chromatiales 135613|Chromatiales E Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) dapA - 4.3.3.7 ko:K01714 ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R10147 RC03062,RC03063 ko00000,ko00001,ko00002,ko01000 - - - DHDPS k59_813495_2 1174684.EBMC1_14520 7.67e-37 138.0 COG3119@1|root,COG3119@2|Bacteria,1MV0B@1224|Proteobacteria,2TRI6@28211|Alphaproteobacteria,2KB25@204457|Sphingomonadales 204457|Sphingomonadales P Sulfatase - - - - - - - - - - - - Sulfatase k59_1434532_1 521011.Mpal_2670 9.38e-09 63.2 COG3291@1|root,arCOG03991@1|root,arCOG02508@2157|Archaea,arCOG03991@2157|Archaea 2157|Archaea S Repeats in polycystic kidney disease 1 (PKD1) and other proteins - - - - - - - - - - - - CBM_6,NosD,PKD,PQQ_3 k59_926371_1 1453501.JELR01000001_gene2922 2.9e-132 408.0 COG0587@1|root,COG0587@2|Bacteria,1MUIF@1224|Proteobacteria,1RP0K@1236|Gammaproteobacteria,464YY@72275|Alteromonadaceae 1236|Gammaproteobacteria L DNA polymerase III alpha subunit dnaE GO:0003674,GO:0003824,GO:0003887,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032991,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0042575,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044776,GO:0046483,GO:0061695,GO:0071704,GO:0071897,GO:0090304,GO:0140097,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234 2.7.7.7 ko:K02337 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon k59_474173_1 1131269.AQVV01000001_gene1419 8.72e-15 78.2 COG0437@1|root,COG0437@2|Bacteria 2|Bacteria C 4 iron, 4 sulfur cluster binding napG GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K02573 - - - - ko00000 - - - Fer4,Fer4_4,Fer4_7 k59_363446_1 1122137.AQXF01000003_gene2087 1.1e-61 204.0 COG0624@1|root,COG0624@2|Bacteria,1MWJS@1224|Proteobacteria,2TUHT@28211|Alphaproteobacteria 28211|Alphaproteobacteria E COG0624 Acetylornithine deacetylase Succinyl-diaminopimelate desuccinylase and related deacylases - - - - - - - - - - - - M20_dimer,Peptidase_M20,Peptidase_M28 k59_363446_2 1122137.AQXF01000003_gene2088 6.03e-26 105.0 COG1228@1|root,COG1228@2|Bacteria,1MVAF@1224|Proteobacteria,2U0BD@28211|Alphaproteobacteria 28211|Alphaproteobacteria Q Amidohydrolase family - - - - - - - - - - - - Amidohydro_1 k59_871921_1 1049564.TevJSym_aa00570 8.16e-115 347.0 COG0728@1|root,COG0728@2|Bacteria,1MUH0@1224|Proteobacteria,1RMXX@1236|Gammaproteobacteria,1J4CG@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria U Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane murJ GO:0000270,GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0006810,GO:0006869,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0010876,GO:0015647,GO:0015648,GO:0015835,GO:0015836,GO:0016020,GO:0016021,GO:0016043,GO:0022857,GO:0022884,GO:0030203,GO:0031224,GO:0031226,GO:0033036,GO:0034203,GO:0034204,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044425,GO:0044459,GO:0044464,GO:0046836,GO:0051179,GO:0051234,GO:0055085,GO:0061024,GO:0065007,GO:0065008,GO:0070589,GO:0071554,GO:0071702,GO:0071704,GO:0071705,GO:0071840,GO:0071944,GO:0097035,GO:1901135,GO:1901137,GO:1901264,GO:1901505,GO:1901564,GO:1901566,GO:1901576 - ko:K03980 - - - - ko00000,ko01011,ko02000 2.A.66.4 - iECO103_1326.ECO103_1114 MVIN k59_588270_1 290400.Jann_2106 6.34e-65 206.0 COG1028@1|root,COG1028@2|Bacteria,1MURZ@1224|Proteobacteria,2TQJ6@28211|Alphaproteobacteria 28211|Alphaproteobacteria IQ COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) MA20_27190 - 1.1.1.30 ko:K00019,ko:K18335 ko00051,ko00072,ko00650,ko01100,ko01120,map00051,map00072,map00650,map01100,map01120 M00088 R01361,R10690 RC00089,RC00117 ko00000,ko00001,ko00002,ko01000 - - - adh_short_C2 k59_588270_2 930166.CD58_18030 2.11e-19 87.8 COG3618@1|root,COG3618@2|Bacteria,1P5PT@1224|Proteobacteria,1S2M5@1236|Gammaproteobacteria 1236|Gammaproteobacteria S amidohydrolase - - - ko:K07046 ko00051,ko01120,map00051,map01120 - R10689 RC00537 ko00000,ko00001,ko01000 - - - Amidohydro_2 k59_1549480_1 391037.Sare_2284 1.78e-88 273.0 COG0372@1|root,COG0372@2|Bacteria,2GJ7E@201174|Actinobacteria,4DBIY@85008|Micromonosporales 201174|Actinobacteria C Belongs to the citrate synthase family gltA GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944 2.3.3.1 ko:K01647 ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00740 R00351 RC00004,RC00067 br01601,ko00000,ko00001,ko00002,ko01000 - - - Citrate_synt k59_701492_1 323848.Nmul_A1846 1.06e-91 281.0 COG0247@1|root,COG0247@2|Bacteria,1MWTK@1224|Proteobacteria,2VJ6T@28216|Betaproteobacteria,372WA@32003|Nitrosomonadales 28216|Betaproteobacteria C Cysteine-rich domain - - - - - - - - - - - - CCG,DUF3501 k59_1549482_1 396588.Tgr7_2791 1.35e-36 134.0 COG3137@1|root,COG3137@2|Bacteria,1MWI4@1224|Proteobacteria,1RN4J@1236|Gammaproteobacteria,1WZ1V@135613|Chromatiales 135613|Chromatiales M Protein of unknown function, DUF481 - - - ko:K07283 - - - - ko00000 - - - DUF481 k59_306768_1 316407.21321913 6.88e-18 80.5 COG0289@1|root,COG0289@2|Bacteria,1MUCT@1224|Proteobacteria,1RMCZ@1236|Gammaproteobacteria,3XMUX@561|Escherichia 1236|Gammaproteobacteria E Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate dapB GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008839,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0019752,GO:0019877,GO:0042802,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.17.1.8 ko:K00215 ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R04198,R04199 RC00478 ko00000,ko00001,ko00002,ko01000 - - iSbBS512_1146.SbBS512_E0035 DapB_C,DapB_N k59_306768_2 316407.21321912 8.67e-95 282.0 COG1957@1|root,COG1957@2|Bacteria,1MUIW@1224|Proteobacteria,1RQ1V@1236|Gammaproteobacteria,3XNKR@561|Escherichia 1236|Gammaproteobacteria F Hydrolyzes both purine and pyrimidine ribonucleosides with a broad-substrate specificity rihC GO:0003674,GO:0003824,GO:0005488,GO:0005509,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006152,GO:0006213,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008477,GO:0009056,GO:0009116,GO:0009119,GO:0009164,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019439,GO:0033554,GO:0034641,GO:0034655,GO:0034656,GO:0042278,GO:0042454,GO:0042802,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0045437,GO:0046131,GO:0046133,GO:0046135,GO:0046483,GO:0046700,GO:0046872,GO:0047622,GO:0047724,GO:0050263,GO:0050896,GO:0051716,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:0072527,GO:0072529,GO:1901135,GO:1901136,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575,GO:1901657,GO:1901658 3.2.2.8 ko:K10213,ko:K12700 ko00230,ko00240,ko01100,map00230,map00240,map01100 - R01245,R01677,R01770,R02137 RC00063,RC00318 ko00000,ko00001,ko01000 - - iECH74115_1262.ECH74115_3298,iECNA114_1301.ECNA114_0014,iECSP_1301.ECSP_3040,iECs_1301.ECs3054,iEcE24377_1341.EcE24377A_0030,iLF82_1304.LF82_1885,iNRG857_1313.NRG857_00145,iYL1228.KPN_00025,iZ_1308.Z3419 IU_nuc_hydro k59_1041688_1 1283300.ATXB01000001_gene2068 7.85e-19 88.2 COG1611@1|root,COG1611@2|Bacteria,1MU6N@1224|Proteobacteria,1S032@1236|Gammaproteobacteria,1XEKP@135618|Methylococcales 135618|Methylococcales S Possible lysine decarboxylase - - 3.2.2.10 ko:K06966 ko00230,ko00240,map00230,map00240 - R00182,R00510 RC00063,RC00318 ko00000,ko00001,ko01000 - - - Lysine_decarbox k59_1661596_1 246197.MXAN_3779 6.16e-55 198.0 COG0318@1|root,COG1020@1|root,COG3321@1|root,COG0318@2|Bacteria,COG1020@2|Bacteria,COG3321@2|Bacteria,1MU6G@1224|Proteobacteria 1224|Proteobacteria IQ COG0318, Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II - - - - - - - - - - - - AMP-binding,AMP-binding_C,Acyl_transf_1,Bac_luciferase,Condensation,KAsynt_C_assoc,Ketoacyl-synt_C,Methyltransf_25,PP-binding,Thioesterase,ketoacyl-synt k59_1264790_1 765911.Thivi_2864 5.35e-74 233.0 COG5008@1|root,COG5008@2|Bacteria,1QTTX@1224|Proteobacteria,1RN0B@1236|Gammaproteobacteria,1WX4M@135613|Chromatiales 135613|Chromatiales NU PFAM Type II secretion system protein E - - - ko:K02670 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE k59_474185_1 123214.PERMA_0750 1.28e-19 94.4 COG2199@1|root,COG2202@1|root,COG2202@2|Bacteria,COG3706@2|Bacteria 2|Bacteria T GGDEF domain - - - - - - - - - - - - GAF,GGDEF,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg k59_1549489_1 13689.BV96_01972 6.42e-168 477.0 COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,2TQKE@28211|Alphaproteobacteria,2K093@204457|Sphingomonadales 204457|Sphingomonadales I acyl-CoA dehydrogenase - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_1549489_2 13689.BV96_02793 2.57e-46 156.0 COG1028@1|root,COG1028@2|Bacteria,1MUBQ@1224|Proteobacteria,2TRPN@28211|Alphaproteobacteria,2K13W@204457|Sphingomonadales 204457|Sphingomonadales IQ Belongs to the short-chain dehydrogenases reductases (SDR) family - - - - - - - - - - - - adh_short k59_81134_1 1122197.ATWI01000009_gene1525 1.09e-05 49.3 COG0204@1|root,COG0204@2|Bacteria,1MUFH@1224|Proteobacteria,1RNJQ@1236|Gammaproteobacteria,465A9@72275|Alteromonadaceae 1236|Gammaproteobacteria I Phosphate acyltransferases - - - - - - - - - - - - Acyltransferase k59_1493260_1 869213.JCM21142_31012 7.43e-57 193.0 COG0542@1|root,COG0542@2|Bacteria,4NE1J@976|Bacteroidetes,47JFM@768503|Cytophagia 976|Bacteroidetes O Belongs to the ClpA ClpB family clpC - - ko:K03696 ko01100,map01100 - - - ko00000,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N,UVR k59_23843_1 436308.Nmar_0546 9.45e-105 315.0 COG0436@1|root,COG1605@1|root,arCOG01130@2157|Archaea,arCOG02098@2157|Archaea,41SBV@651137|Thaumarchaeota 651137|Thaumarchaeota E Chorismate mutase type II - - 2.6.1.1 ko:K00812 ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230 - R00355,R00694,R00734,R00896,R02433,R02619,R05052 RC00006 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_1_2,CM_2 k59_529893_1 228410.NE0375 6.31e-32 128.0 COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,2VHCZ@28216|Betaproteobacteria,371S7@32003|Nitrosomonadales 28216|Betaproteobacteria P Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K15726 - - - - ko00000,ko02000 2.A.6.1.2 - - ACR_tran k59_1322142_1 1005999.GLGR_0432 2.22e-13 68.9 COG2976@1|root,COG2976@2|Bacteria,1N117@1224|Proteobacteria,1S95P@1236|Gammaproteobacteria 1236|Gammaproteobacteria S protein conserved in bacteria yfgM GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0009897,GO:0009986,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0031233,GO:0044425,GO:0044459,GO:0044464,GO:0071575,GO:0071944,GO:0098552 - - - - - - - - - - TPR_21 k59_1322142_2 1072685.IX83_04490 7.12e-09 59.7 COG0124@1|root,COG0124@2|Bacteria,1MV2K@1224|Proteobacteria,2VIGA@28216|Betaproteobacteria,3T1JP@506|Alcaligenaceae 28216|Betaproteobacteria J histidyl-tRNA synthetase hisS - 6.1.1.21 ko:K01892 ko00970,map00970 M00359,M00360 R03655 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,tRNA-synt_His k59_1380001_1 351607.Acel_0651 1.64e-65 217.0 COG0056@1|root,COG0056@2|Bacteria,2GJRJ@201174|Actinobacteria,4ERF0@85013|Frankiales 201174|Actinobacteria C Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit atpA GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944 3.6.3.14 ko:K02111 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - - ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N k59_1380001_2 1449126.JQKL01000005_gene874 4.49e-15 74.7 COG0224@1|root,COG0224@2|Bacteria,1TPBX@1239|Firmicutes,2486Q@186801|Clostridia,268Q6@186813|unclassified Clostridiales 186801|Clostridia C Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex atpG GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K02115 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt k59_306784_1 1317124.DW2_00165 7.35e-10 58.5 COG0395@1|root,COG0395@2|Bacteria,1N4I0@1224|Proteobacteria,2TT14@28211|Alphaproteobacteria,2XKZH@285107|Thioclava 28211|Alphaproteobacteria U Binding-protein-dependent transport system inner membrane component - - - - - - - - - - - - BPD_transp_1 k59_306784_2 1317124.DW2_00170 8.39e-112 331.0 COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,2TQQJ@28211|Alphaproteobacteria,2XN2W@285107|Thioclava 28211|Alphaproteobacteria E Part of the ABC transporter complex UgpABCE involved in sn-glycerol-3-phosphate import. Responsible for energy coupling to the transport system - - - ko:K10112 ko02010,map02010 M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1 - - ABC_tran,TOBE,TOBE_2 k59_23857_1 1244869.H261_07618 7.55e-38 149.0 COG5002@1|root,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,2TWEB@28211|Alphaproteobacteria 28211|Alphaproteobacteria T Histidine kinase - - 2.7.13.3 ko:K07716 ko02020,ko04112,map02020,map04112 M00511 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA,PAS_3,PAS_4,PAS_7 k59_23857_2 1122137.AQXF01000003_gene1987 2.88e-96 291.0 COG5285@1|root,COG5285@2|Bacteria,1R54T@1224|Proteobacteria,2TUEA@28211|Alphaproteobacteria 28211|Alphaproteobacteria Q Phytanoyl-CoA dioxygenase - - - - - - - - - - - - PhyH k59_1773274_1 1397527.Q670_04585 6.25e-23 102.0 COG2304@1|root,COG3419@1|root,COG2304@2|Bacteria,COG3419@2|Bacteria,1NUAV@1224|Proteobacteria,1RPV3@1236|Gammaproteobacteria,1XI4X@135619|Oceanospirillales 135619|Oceanospirillales NU COG3419 Tfp pilus assembly protein, tip-associated adhesin PilY1 - - - ko:K02674 - - - - ko00000,ko02035,ko02044 - - - Neisseria_PilC,VWA_2 k59_23859_1 398767.Glov_1980 1.41e-54 176.0 COG0225@1|root,COG0225@2|Bacteria,1R33Z@1224|Proteobacteria,42RS2@68525|delta/epsilon subdivisions,2X9GK@28221|Deltaproteobacteria,43W2H@69541|Desulfuromonadales 28221|Deltaproteobacteria O Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine msrA - 1.8.4.11 ko:K07304 - - - - ko00000,ko01000 - - - PMSR k59_701538_2 1537994.JQFW01000015_gene1638 9.44e-22 90.5 COG2010@1|root,COG2010@2|Bacteria,1N5P8@1224|Proteobacteria,1S9K3@1236|Gammaproteobacteria,46AXG@72275|Alteromonadaceae 1236|Gammaproteobacteria C Cytochrome c - - - - - - - - - - - - Cytochrom_C k59_249107_1 1205680.CAKO01000030_gene4923 4.43e-20 90.5 COG1960@1|root,COG1960@2|Bacteria,1MU20@1224|Proteobacteria,2TQU2@28211|Alphaproteobacteria,2JV5K@204441|Rhodospirillales 204441|Rhodospirillales I Acyl-CoA dehydrogenase, C-terminal domain - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M k59_249107_2 626887.J057_09126 4.76e-18 81.6 COG0421@1|root,COG0421@2|Bacteria,1QUUH@1224|Proteobacteria,1T268@1236|Gammaproteobacteria,466KQ@72275|Alteromonadaceae 1236|Gammaproteobacteria E COG0421 Spermidine synthase - - - - - - - - - - - - - k59_1095941_1 316407.85676512 2.77e-155 456.0 COG1215@1|root,COG1215@2|Bacteria,1MWF8@1224|Proteobacteria,1RPJ6@1236|Gammaproteobacteria,3XNAD@561|Escherichia 1236|Gammaproteobacteria M Binds the cellulose synthase activator, bis-(3'-5') cyclic diguanylic acid (c-di-GMP) bcsB GO:0000271,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0005976,GO:0006073,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0016020,GO:0016051,GO:0030243,GO:0030244,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044464,GO:0051273,GO:0051274,GO:0071704,GO:0071944,GO:0090540,GO:1901576 2.4.1.12 ko:K00694,ko:K20541 ko00500,ko01100,ko02026,map00500,map01100,map02026 - R02889 RC00005 ko00000,ko00001,ko01000,ko01003,ko02000 4.D.3.1.2,4.D.3.1.5,4.D.3.1.6 GT2 - BcsB,Glyco_hydro_17,Glyco_tranf_2_3,Glycos_transf_2 k59_474219_1 697282.Mettu_3448 1.32e-73 243.0 COG2307@1|root,COG2308@1|root,COG2307@2|Bacteria,COG2308@2|Bacteria,1MX5P@1224|Proteobacteria,1RPDC@1236|Gammaproteobacteria,1XG1Q@135618|Methylococcales 135618|Methylococcales S Circularly permuted ATP-grasp type 2 - - - - - - - - - - - - Alpha-E,CP_ATPgrasp_2 k59_81190_1 396588.Tgr7_0319 7.94e-61 197.0 COG0266@1|root,COG0266@2|Bacteria,1MVM5@1224|Proteobacteria,1RP3J@1236|Gammaproteobacteria,1WX0V@135613|Chromatiales 135613|Chromatiales L Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates fpg - 3.2.2.23,4.2.99.18 ko:K10563 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - Fapy_DNA_glyco,H2TH,zf-FPG_IleRS k59_1661641_1 1121286.AUMT01000010_gene3893 7.28e-15 71.2 2EGFG@1|root,33A7G@2|Bacteria,4PFR6@976|Bacteroidetes,1I6E0@117743|Flavobacteriia,3ZS8P@59732|Chryseobacterium 976|Bacteroidetes - - - - - - - - - - - - - - - k59_249127_1 288000.BBta_1006 1.6e-21 90.9 COG1045@1|root,COG1045@2|Bacteria,1RA58@1224|Proteobacteria,2VEY1@28211|Alphaproteobacteria,3K3TQ@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria E Hexapeptide repeat of succinyl-transferase - - 2.3.1.30 ko:K00640 ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111 M00021 R00586 RC00004,RC00041 ko00000,ko00001,ko00002,ko01000 - - - Hexapep k59_1322173_1 1219045.BV98_002756 1e-67 233.0 COG1629@1|root,COG4771@2|Bacteria,1R4SS@1224|Proteobacteria 1224|Proteobacteria P TonB dependent receptor - - - - - - - - - - - - Plug,TonB_dep_Rec k59_701560_1 156578.ATW7_11080 7.07e-56 192.0 COG0457@1|root,COG0457@2|Bacteria,1Q3YA@1224|Proteobacteria,1RN2D@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Peptidase family M49 - - - - - - - - - - - - Peptidase_M49 k59_813559_1 1408419.JHYG01000001_gene1830 1.52e-88 275.0 COG4307@1|root,COG4307@2|Bacteria,1MW31@1224|Proteobacteria,2TRR9@28211|Alphaproteobacteria,2JQCY@204441|Rhodospirillales 204441|Rhodospirillales S Putative zinc-binding metallo-peptidase - - - - - - - - - - - - Peptidase_Mx,zinc-ribbon_6 k59_1264836_1 1229909.NSED_06385 2.77e-116 342.0 COG0372@1|root,arCOG04237@2157|Archaea,41SAN@651137|Thaumarchaeota 651137|Thaumarchaeota C TIGRFAM 2-methylcitrate synthase citrate synthase II - - 2.3.3.1 ko:K01647 ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00740 R00351 RC00004,RC00067 br01601,ko00000,ko00001,ko00002,ko01000 - - - Citrate_synt k59_136789_2 1090320.KB900605_gene2770 3.68e-20 96.7 COG4221@1|root,COG4221@2|Bacteria,1MUU6@1224|Proteobacteria,2TQW8@28211|Alphaproteobacteria,2K2E4@204457|Sphingomonadales 204457|Sphingomonadales S Belongs to the short-chain dehydrogenases reductases (SDR) family - - - - - - - - - - - - adh_short k59_1161531_2 1137281.D778_01687 1.84e-73 224.0 COG1057@1|root,COG1057@2|Bacteria,4NFQI@976|Bacteroidetes,1HYH0@117743|Flavobacteriia 976|Bacteroidetes H Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) nadD - 2.7.7.18 ko:K00969 ko00760,ko01100,map00760,map01100 M00115 R00137,R03005 RC00002 ko00000,ko00001,ko00002,ko01000 - - - CTP_transf_like k59_1560019_1 743718.Isova_2989 2.37e-11 67.0 COG0559@1|root,COG0559@2|Bacteria,2GKAR@201174|Actinobacteria,4F5DK@85017|Promicromonosporaceae 201174|Actinobacteria E Branched-chain amino acid transport system / permease component - - - ko:K01997 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - BPD_transp_2 k59_1161534_1 1348657.M622_01190 4.52e-82 268.0 COG3383@1|root,COG3383@2|Bacteria,1QTZB@1224|Proteobacteria,2VP2Q@28216|Betaproteobacteria,2KVNP@206389|Rhodocyclales 206389|Rhodocyclales C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - 1.17.1.9 ko:K00123 ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200 - R00519 RC02796 ko00000,ko00001,ko01000 - - - Fer2_4,Fer4_7,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3 k59_1161534_2 243233.MCA1390 3.38e-36 134.0 COG1526@1|root,COG1526@2|Bacteria,1NRU0@1224|Proteobacteria,1RNFH@1236|Gammaproteobacteria,1XDUR@135618|Methylococcales 135618|Methylococcales C Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH fdhD - - ko:K02379 - - - - ko00000 - - - FdhD-NarQ k59_1218794_1 870187.Thini_1264 6.28e-62 191.0 COG0633@1|root,COG0633@2|Bacteria,1RHDC@1224|Proteobacteria,1S5XW@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Ferredoxin, 2Fe-2S type, ISC system fdx - - ko:K04755 - - - - ko00000 - - - Fer2 k59_1218794_2 55601.VANGNB10_cI0667 9.93e-27 111.0 COG0443@1|root,COG0443@2|Bacteria,1MVQI@1224|Proteobacteria,1RN74@1236|Gammaproteobacteria,1XT9W@135623|Vibrionales 135623|Vibrionales O Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB hscA GO:0006457,GO:0008150,GO:0009987 - ko:K04044 - - - - ko00000,ko03110 1.A.33 - - HSP70 k59_1614162_2 585530.HMPREF0183_2414 3.56e-54 188.0 COG1160@1|root,COG1160@2|Bacteria,2GJ8J@201174|Actinobacteria,4F8AG@85019|Brevibacteriaceae 201174|Actinobacteria S GTPase that plays an essential role in the late steps of ribosome biogenesis der GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944 - ko:K03977 - - - - ko00000,ko03009 - - - Cytidylate_kin,KH_dom-like,MMR_HSR1 k59_821215_1 1381123.AYOD01000025_gene1518 1.01e-22 97.1 COG0657@1|root,COG0657@2|Bacteria,1N2XW@1224|Proteobacteria,2U3QT@28211|Alphaproteobacteria,43M37@69277|Phyllobacteriaceae 28211|Alphaproteobacteria I alpha/beta hydrolase fold - - - - - - - - - - - - Abhydrolase_3,COesterase,Peptidase_S9 k59_1050650_1 398525.KB900701_gene3347 3.02e-69 224.0 28KNR@1|root,2Z9F7@2|Bacteria,1NC4P@1224|Proteobacteria,2TSTI@28211|Alphaproteobacteria,3JTPT@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S Glycosyl hydrolase family 79, N-terminal domain - - - - - - - - - - - - Glyco_hydro_79n k59_1561395_1 377629.TERTU_0883 1.35e-77 258.0 COG0085@1|root,COG0085@2|Bacteria,1MUC4@1224|Proteobacteria,1RMK0@1236|Gammaproteobacteria,2PMMQ@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria K RNA polymerase beta subunit external 1 domain rpoB GO:0000428,GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0030880,GO:0032774,GO:0032991,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234 2.7.7.6 ko:K03043 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7 k59_651940_1 1249997.JHZW01000003_gene2380 1.13e-95 282.0 COG0450@1|root,COG0450@2|Bacteria,4NEDT@976|Bacteroidetes,1HWZW@117743|Flavobacteriia,2PG3Q@252356|Maribacter 976|Bacteroidetes O C-terminal domain of 1-Cys peroxiredoxin ahpC - 1.11.1.15 ko:K03386 ko04214,map04214 - - - ko00000,ko00001,ko01000,ko04147 - - - 1-cysPrx_C,AhpC-TSA k59_1504213_1 1122137.AQXF01000003_gene2066 1.99e-141 431.0 COG0458@1|root,COG0458@2|Bacteria,1MUDZ@1224|Proteobacteria,2TQZU@28211|Alphaproteobacteria 28211|Alphaproteobacteria F Belongs to the CarB family carB - 6.3.5.5 ko:K01955 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - - CPSase_L_D2,CPSase_L_D3,MGS k59_1219690_1 1117647.M5M_10800 8e-72 226.0 COG3637@1|root,COG3637@2|Bacteria,1PXDF@1224|Proteobacteria,1TC33@1236|Gammaproteobacteria,1JBGY@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety - - - - - - - - - - - - - k59_712450_1 1122137.AQXF01000002_gene198 5.72e-58 182.0 COG4319@1|root,COG4319@2|Bacteria,1RDBF@1224|Proteobacteria,2U7AM@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Domain of unknown function (DUF4440) - - - - - - - - - - - - DUF4440 k59_712450_2 629773.AORY01000002_gene1460 2.26e-119 353.0 COG2021@1|root,COG2021@2|Bacteria,1MVJV@1224|Proteobacteria,2TTTV@28211|Alphaproteobacteria,2K296@204457|Sphingomonadales 204457|Sphingomonadales E alpha/beta hydrolase fold - - 2.3.1.31 ko:K00641 ko00270,ko01100,ko01130,map00270,map01100,map01130 - R01776 RC00004,RC00041 ko00000,ko00001,ko01000 - - - Abhydrolase_1 k59_1272933_1 1178825.ALIH01000006_gene1428 2.56e-84 272.0 COG1200@1|root,COG1200@2|Bacteria,4NDZV@976|Bacteroidetes,1HX1Z@117743|Flavobacteriia 976|Bacteroidetes L Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) recG - 3.6.4.12 ko:K03655 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,Helicase_C,RecG_wedge k59_1669873_1 1366050.N234_03785 4.79e-63 207.0 COG3146@1|root,COG3146@2|Bacteria,1MU35@1224|Proteobacteria,2VH0Z@28216|Betaproteobacteria,1K1ZD@119060|Burkholderiaceae 28216|Betaproteobacteria S Peptidogalycan biosysnthesis/recognition - - - ko:K09919 - - - - ko00000 - - - FemAB_like k59_1391164_1 436308.Nmar_0512 1.19e-77 240.0 COG1522@1|root,arCOG01628@2157|Archaea,41SA2@651137|Thaumarchaeota 651137|Thaumarchaeota K COG1522 Transcriptional regulators - - - - - - - - - - - - - k59_374552_1 1088721.NSU_2191 2.13e-99 295.0 COG1354@1|root,COG1354@2|Bacteria,1MVCN@1224|Proteobacteria,2TS1V@28211|Alphaproteobacteria,2K15W@204457|Sphingomonadales 204457|Sphingomonadales D Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves scpA - - ko:K05896 - - - - ko00000,ko03036 - - - SMC_ScpA k59_537120_1 713587.THITH_16865 6.11e-53 188.0 COG2203@1|root,COG2206@1|root,COG3221@1|root,COG2203@2|Bacteria,COG2206@2|Bacteria,COG3221@2|Bacteria,1RAQS@1224|Proteobacteria,1S4K4@1236|Gammaproteobacteria,1X2BG@135613|Chromatiales 135613|Chromatiales T HD domain - - - - - - - - - - - - GAF_2,HD,PAS_4 k59_481976_1 1144307.PMI04_01050 1.87e-10 58.9 COG4319@1|root,COG4319@2|Bacteria,1R2NE@1224|Proteobacteria,2UWNA@28211|Alphaproteobacteria,2K8A2@204457|Sphingomonadales 204457|Sphingomonadales S SnoaL-like domain - - - - - - - - - - - - SnoaL_4 k59_481976_3 1144307.PMI04_04561 2.44e-06 48.5 COG1028@1|root,COG1028@2|Bacteria,1MXNQ@1224|Proteobacteria,2TS6G@28211|Alphaproteobacteria,2KCN3@204457|Sphingomonadales 204457|Sphingomonadales IQ KR domain - - - - - - - - - - - - adh_short k59_1727707_1 1090319.KE386571_gene1513 3.09e-80 262.0 COG1629@1|root,COG1629@2|Bacteria,COG4771@2|Bacteria,1MV8W@1224|Proteobacteria,2TSUV@28211|Alphaproteobacteria,2JZV0@204457|Sphingomonadales 28211|Alphaproteobacteria P receptor - - - - - - - - - - - - Plug,TonB_dep_Rec k59_1561450_1 96561.Dole_0337 3.37e-29 121.0 COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,42M5F@68525|delta/epsilon subdivisions,2WISF@28221|Deltaproteobacteria,2MI8R@213118|Desulfobacterales 28221|Deltaproteobacteria IQ PFAM AMP-dependent synthetase and ligase - - 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding,AMP-binding_C k59_259860_1 316407.85674545 2.15e-118 345.0 COG0809@1|root,COG0809@2|Bacteria,1MUH3@1224|Proteobacteria,1RMKW@1236|Gammaproteobacteria,3XNYX@561|Escherichia 1236|Gammaproteobacteria F Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) queA GO:0002097,GO:0002099,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009314,GO:0009451,GO:0009628,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016853,GO:0018130,GO:0019438,GO:0034404,GO:0034470,GO:0034641,GO:0034654,GO:0034660,GO:0042455,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046116,GO:0046483,GO:0050896,GO:0051075,GO:0055086,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.4.99.17 ko:K07568 - - - - ko00000,ko01000,ko03016 - - - Queuosine_synth k59_1442694_1 452637.Oter_1154 7.4e-21 94.0 COG3391@1|root,COG4625@1|root,COG5563@1|root,COG3391@2|Bacteria,COG4625@2|Bacteria,COG5563@2|Bacteria 2|Bacteria T pathogenesis - - 3.1.3.1,3.1.3.5,3.1.3.8,3.6.1.45 ko:K01077,ko:K01083,ko:K07004,ko:K11751 ko00230,ko00240,ko00562,ko00730,ko00760,ko00790,ko01100,ko01110,ko02020,map00230,map00240,map00562,map00730,map00760,map00790,map01100,map01110,map02020 M00126 R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02135,R02323,R02719,R03346,R03371,R04620 RC00017,RC00078 ko00000,ko00001,ko00002,ko00537,ko01000,ko04147 - - - 5_nucleotid_C,Calx-beta,Phytase-like k59_1391199_1 153948.NAL212_2928 3.88e-10 60.1 COG2805@1|root,COG2805@2|Bacteria,1MU3J@1224|Proteobacteria,2VHHW@28216|Betaproteobacteria,372KB@32003|Nitrosomonadales 28216|Betaproteobacteria NU PFAM Type II secretion system protein E pilT - - ko:K02669,ko:K12203 - - - - ko00000,ko02035,ko02044 3.A.15.2,3.A.7.10.1,3.A.7.9.1 - - T2SSE k59_1391199_2 572477.Alvin_2323 3.87e-52 177.0 COG5008@1|root,COG5008@2|Bacteria,1QTTX@1224|Proteobacteria,1RN0B@1236|Gammaproteobacteria,1WX16@135613|Chromatiales 135613|Chromatiales NU PFAM Type II secretion system protein E - - - ko:K02670 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE k59_882938_1 1229909.NSED_01820 1.51e-31 113.0 COG2058@1|root,arCOG04287@2157|Archaea,41SP0@651137|Thaumarchaeota 651137|Thaumarchaeota J Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors rpl12 - - ko:K02869 ko03010,map03010 M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_60s k59_882938_2 436308.Nmar_0373 3.98e-49 160.0 arCOG08745@1|root,arCOG08745@2157|Archaea,41SU1@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_259870_2 1163617.SCD_n01413 3.55e-15 78.2 COG3829@1|root,COG5001@1|root,COG3829@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria 28216|Betaproteobacteria T Diguanylate cyclase - - - - - - - - - - - - EAL,GGDEF,HAMP,PAS_3,PAS_9,Response_reg k59_259870_3 326424.FRAAL5820 1.28e-20 91.3 COG0766@1|root,COG0766@2|Bacteria,2GJPW@201174|Actinobacteria,4ETNF@85013|Frankiales 201174|Actinobacteria M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine - - 2.5.1.7 ko:K00790 ko00520,ko00550,ko01100,map00520,map00550,map01100 - R00660 RC00350 ko00000,ko00001,ko01000,ko01011 - - - EPSP_synthase k59_651987_1 1122137.AQXF01000003_gene2182 7.82e-50 171.0 COG0161@1|root,COG0161@2|Bacteria,1MU2N@1224|Proteobacteria,2TQND@28211|Alphaproteobacteria 2|Bacteria E Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family - - - - - - - - - - - - Aminotran_3 k59_1561467_1 1280952.HJA_03056 1.2e-07 53.1 COG2353@1|root,COG2353@2|Bacteria,1RGBV@1224|Proteobacteria,2U8TX@28211|Alphaproteobacteria,43XUR@69657|Hyphomonadaceae 28211|Alphaproteobacteria S Belongs to the UPF0312 family - - - - - - - - - - - - YceI k59_1561467_2 1122137.AQXF01000001_gene3217 1.43e-50 162.0 COG3793@1|root,COG3793@2|Bacteria,1RD1X@1224|Proteobacteria,2U788@28211|Alphaproteobacteria 28211|Alphaproteobacteria P PFAM Mo-dependent nitrogenase - - - - - - - - - - - - TerB k59_1219731_1 1996.JOFO01000001_gene3917 1.3e-43 160.0 COG2124@1|root,COG2124@2|Bacteria,2GJ8V@201174|Actinobacteria,4EFQA@85012|Streptosporangiales 201174|Actinobacteria Q Cytochrome P450 - - - - - - - - - - - - p450 k59_1329824_1 393283.XP_007829621.1 1.23e-05 52.8 COG1404@1|root,KOG1153@2759|Eukaryota,38H6S@33154|Opisthokonta,3NUCW@4751|Fungi,3QK5M@4890|Ascomycota,212T4@147550|Sordariomycetes 4751|Fungi O Belongs to the peptidase S8 family PRB1 GO:0000003,GO:0000322,GO:0000323,GO:0000324,GO:0000328,GO:0000746,GO:0000747,GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005773,GO:0005775,GO:0005783,GO:0006508,GO:0006807,GO:0006914,GO:0006950,GO:0006996,GO:0007033,GO:0007039,GO:0007154,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0009056,GO:0009057,GO:0009267,GO:0009605,GO:0009653,GO:0009987,GO:0009991,GO:0012505,GO:0016043,GO:0016787,GO:0017171,GO:0019538,GO:0019863,GO:0019865,GO:0019953,GO:0019954,GO:0022414,GO:0030154,GO:0030163,GO:0030435,GO:0030436,GO:0031667,GO:0031668,GO:0031669,GO:0031974,GO:0032502,GO:0033554,GO:0042594,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043934,GO:0043936,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044422,GO:0044424,GO:0044437,GO:0044444,GO:0044446,GO:0044464,GO:0044703,GO:0044764,GO:0044877,GO:0048646,GO:0048856,GO:0048869,GO:0050896,GO:0051704,GO:0051716,GO:0061919,GO:0070011,GO:0070013,GO:0071496,GO:0071704,GO:0071840,GO:0140096,GO:1901564,GO:1901565,GO:1901575 3.4.21.48 ko:K01336 ko04138,map04138 - - - ko00000,ko00001,ko01000,ko01002,ko03110 - - - Inhibitor_I9,Peptidase_S8 k59_822556_1 330214.NIDE3016 4.01e-79 240.0 COG1209@1|root,COG1209@2|Bacteria,3J0KX@40117|Nitrospirae 40117|Nitrospirae M Nucleotidyl transferase - - 2.7.7.24 ko:K00973 ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130 M00793 R02328 RC00002 ko00000,ko00001,ko00002,ko01000 - - - NTP_transferase k59_1561472_1 702113.PP1Y_Mpl270 5.73e-27 108.0 COG4188@1|root,COG4188@2|Bacteria,1NAS2@1224|Proteobacteria,2UH1M@28211|Alphaproteobacteria,2KEQQ@204457|Sphingomonadales 204457|Sphingomonadales S dienelactone hydrolase - - - - - - - - - - - - - k59_318058_1 222534.KB893766_gene2941 3.39e-72 239.0 COG1961@1|root,COG1961@2|Bacteria,2I8HV@201174|Actinobacteria 201174|Actinobacteria L COG1961 Site-specific recombinases, DNA invertase Pin homologs - - - - - - - - - - - - Recombinase,Resolvase,Zn_ribbon_recom k59_1504285_1 58123.JOFJ01000022_gene3593 3.9e-118 349.0 COG1960@1|root,COG1960@2|Bacteria,2GKQI@201174|Actinobacteria,4EHBS@85012|Streptosporangiales 201174|Actinobacteria I Acyl-CoA dehydrogenase, C-terminal domain - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_537149_1 745014.OMB55_00009310 3.35e-22 94.4 COG0534@1|root,COG0534@2|Bacteria,1MV6B@1224|Proteobacteria,1RPGF@1236|Gammaproteobacteria,1J4H3@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria V COG0534 Na -driven multidrug efflux pump dinF - - ko:K03327 - - - - ko00000,ko02000 2.A.66.1 - - MatE k59_537149_2 517722.AEUE01000001_gene2670 1.09e-28 116.0 COG2272@1|root,COG2272@2|Bacteria,1MVQZ@1224|Proteobacteria,2TTHT@28211|Alphaproteobacteria,2K0DZ@204457|Sphingomonadales 204457|Sphingomonadales I Belongs to the type-B carboxylesterase lipase family - - - - - - - - - - - - COesterase k59_1104259_1 1131266.ARWQ01000001_gene1205 2.82e-39 139.0 COG0533@1|root,arCOG01183@2157|Archaea,41SDX@651137|Thaumarchaeota 651137|Thaumarchaeota L Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37 kae1 - 2.3.1.234 ko:K01409 - - R10648 RC00070,RC00416 ko00000,ko01000,ko03016 - - - Peptidase_M22 k59_1104259_2 436308.Nmar_1534 1.91e-86 265.0 COG0012@1|root,arCOG00357@2157|Archaea,41S71@651137|Thaumarchaeota 651137|Thaumarchaeota J GTPase of unknown function C-terminal - - - ko:K06942 - - - - ko00000,ko03009 - - - MMR_HSR1,MMR_HSR1_C,TGS k59_1504291_1 1207063.P24_06247 3.08e-16 85.1 COG2982@1|root,COG2982@2|Bacteria,1MUNH@1224|Proteobacteria,2TT0W@28211|Alphaproteobacteria,2JR60@204441|Rhodospirillales 204441|Rhodospirillales M protein involved in outer membrane biogenesis - - - - - - - - - - - - AsmA,AsmA_2 k59_1504292_1 1395587.P364_0122565 7.18e-30 122.0 COG5297@1|root,COG5297@2|Bacteria,1V1T2@1239|Firmicutes,4HUDU@91061|Bacilli,26S1Z@186822|Paenibacillaceae 91061|Bacilli G Belongs to the glycosyl hydrolase family 6 - - 3.2.1.4 ko:K01179 ko00500,ko01100,map00500,map01100 - R06200,R11307,R11308 - ko00000,ko00001,ko01000 - GH5,GH9 - CBM_3,Glyco_hydro_9 k59_482014_2 1148.1653944 1.87e-21 93.2 COG2403@1|root,COG2403@2|Bacteria,1G1FF@1117|Cyanobacteria,1H6E6@1142|Synechocystis 1117|Cyanobacteria S cyclic 2,3-diphosphoglycerate synthetase activity - - - - - - - - - - - - cobW k59_318072_1 186497.PF1919 6.18e-36 135.0 COG0673@1|root,arCOG01622@2157|Archaea,2XVFY@28890|Euryarchaeota,243QC@183968|Thermococci 183968|Thermococci S Oxidoreductase family, NAD-binding Rossmann fold - - - - - - - - - - - - GFO_IDH_MocA,GFO_IDH_MocA_C k59_1219748_1 1229909.NSED_07405 5.95e-71 231.0 COG0598@1|root,arCOG02265@2157|Archaea 2157|Archaea P Mediates influx of magnesium ions corA - - ko:K03284 - - - - ko00000,ko02000 1.A.35.1,1.A.35.3 - - CorA k59_90979_1 1283300.ATXB01000001_gene2131 1.09e-33 129.0 COG0477@1|root,COG2814@2|Bacteria,1R43U@1224|Proteobacteria,1RMY8@1236|Gammaproteobacteria 1236|Gammaproteobacteria EGP COG0477 Permeases of the major facilitator superfamily - - - - - - - - - - - - MFS_1 k59_822586_1 744979.R2A130_2286 7.35e-26 102.0 29PQU@1|root,31QPX@2|Bacteria,1RKRW@1224|Proteobacteria,2UB5U@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Protein of unknown function (DUF1203) - - - - - - - - - - - - DUF1203 k59_822586_2 1122137.AQXF01000007_gene3510 1.51e-14 70.1 COG0784@1|root,COG0784@2|Bacteria 2|Bacteria T Response regulator, receiver - - 2.7.13.3 ko:K02487,ko:K03407,ko:K06596 ko02020,ko02025,ko02030,map02020,map02025,map02030 M00506,M00507 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 - - - CheW,HATPase_c,Hpt,Response_reg k59_1329843_1 314231.FP2506_12734 1.03e-60 194.0 COG1853@1|root,COG1853@2|Bacteria,1MUPP@1224|Proteobacteria,2TT7S@28211|Alphaproteobacteria,2PJUK@255475|Aurantimonadaceae 28211|Alphaproteobacteria S Flavin reductase like domain - - - - - - - - - - - - Flavin_Reduct k59_599435_1 1122135.KB893135_gene756 3.75e-91 280.0 COG3033@1|root,COG3033@2|Bacteria,1NG5U@1224|Proteobacteria,2TTAU@28211|Alphaproteobacteria 28211|Alphaproteobacteria E catalyzes the formation of indole and pyruvate from tryptophan - - 4.1.99.2 ko:K01668 ko00350,map00350 - R00728 RC00355,RC00364 ko00000,ko00001,ko01000 - - - Beta_elim_lyase k59_1162894_1 1397666.RS24_00337 1.88e-16 76.3 2BFHU@1|root,2Z8VP@2|Bacteria,1QR3R@1224|Proteobacteria,2UNNX@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_1162894_2 1248760.ANFZ01000009_gene1325 1.46e-53 171.0 2E4NX@1|root,32ZHQ@2|Bacteria,1N0E8@1224|Proteobacteria,2UCZP@28211|Alphaproteobacteria,2K74Q@204457|Sphingomonadales 204457|Sphingomonadales - - - - - - - - - - - - - - - k59_1391248_1 1229909.NSED_03240 2.4e-56 198.0 arCOG08752@1|root,arCOG08752@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_1162896_1 1397527.Q670_01450 2.08e-68 227.0 COG0323@1|root,COG0323@2|Bacteria,1MV61@1224|Proteobacteria,1RM89@1236|Gammaproteobacteria,1XHJY@135619|Oceanospirillales 135619|Oceanospirillales L This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex mutL - - ko:K03572 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - DNA_mis_repair,HATPase_c_3,MutL_C k59_989976_1 498211.CJA_3380 1.38e-52 181.0 COG1301@1|root,COG1301@2|Bacteria,1MU0Q@1224|Proteobacteria,1RMEN@1236|Gammaproteobacteria,1FHYQ@10|Cellvibrio 1236|Gammaproteobacteria U Sodium:dicarboxylate symporter family - - - - - - - - - - - - SDF k59_989976_2 450851.PHZ_c0848 1.41e-43 161.0 COG0739@1|root,COG0739@2|Bacteria,1MVTF@1224|Proteobacteria,2TT3Z@28211|Alphaproteobacteria,2KFZ3@204458|Caulobacterales 204458|Caulobacterales M peptidase - - - - - - - - - - - - Peptidase_M23 k59_882998_1 243231.GSU0003 5.74e-55 192.0 COG0187@1|root,COG0187@2|Bacteria,1MVKT@1224|Proteobacteria,42M7M@68525|delta/epsilon subdivisions,2WJ9X@28221|Deltaproteobacteria,43U22@69541|Desulfuromonadales 28221|Deltaproteobacteria L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrB - 5.99.1.3 ko:K02470 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim k59_1442746_1 1100720.ALKN01000035_gene980 1.09e-36 131.0 COG0235@1|root,COG0235@2|Bacteria,1MWP9@1224|Proteobacteria,2VN0U@28216|Betaproteobacteria,4AI0K@80864|Comamonadaceae 28216|Betaproteobacteria G Class II Aldolase and Adducin N-terminal domain - - - - - - - - - - - - Aldolase_II k59_1442746_2 1038859.AXAU01000006_gene5552 1.56e-21 92.8 COG2267@1|root,COG2267@2|Bacteria,1QU7K@1224|Proteobacteria,2U0H3@28211|Alphaproteobacteria,3JR1E@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria I Serine aminopeptidase, S33 - - 2.7.10.2,3.3.2.9 ko:K01253,ko:K08253 ko00980,ko04976,ko05204,map00980,map04976,map05204 - R07013,R07014,R07027,R07071,R07072,R07082,R09410,R09417,R09443 RC01447,RC01728,RC01764,RC02528 ko00000,ko00001,ko01000,ko01002 - - - Abhydrolase_1 k59_91004_1 765913.ThidrDRAFT_1626 2.61e-83 271.0 COG0653@1|root,COG0653@2|Bacteria,1MUJZ@1224|Proteobacteria,1RM9M@1236|Gammaproteobacteria,1WWZC@135613|Chromatiales 135613|Chromatiales U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane secA - - ko:K03070 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4 - - SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW k59_1329865_1 450851.PHZ_c0896 1.1e-16 80.9 COG0477@1|root,COG2814@2|Bacteria,1QYNP@1224|Proteobacteria,2U1VX@28211|Alphaproteobacteria 28211|Alphaproteobacteria EGP Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 k59_599472_1 1484460.JSWG01000009_gene384 1.48e-47 172.0 COG1752@1|root,COG4775@1|root,COG1752@2|Bacteria,COG4775@2|Bacteria,4NDXY@976|Bacteroidetes,1HWZP@117743|Flavobacteriia 976|Bacteroidetes M esterase of the alpha-beta hydrolase superfamily - - - ko:K07001 - - - - ko00000 - - - POTRA,Patatin k59_318120_1 504487.JCM19302_94 1.14e-88 288.0 COG1629@1|root,COG1629@2|Bacteria,4NDXS@976|Bacteroidetes,1HWYV@117743|Flavobacteriia 976|Bacteroidetes P TonB-dependent receptor plug - - - - - - - - - - - - CarbopepD_reg_2,Plug,TonB_dep_Rec k59_883027_1 870187.Thini_0202 7.21e-55 182.0 COG1305@1|root,COG1305@2|Bacteria,1MVAG@1224|Proteobacteria,1RMXM@1236|Gammaproteobacteria,463S1@72273|Thiotrichales 72273|Thiotrichales E Transglutaminase/protease-like homologues - - - - - - - - - - - - Bact_transglu_N,Transglut_core k59_318123_1 395494.Galf_2472 3.44e-82 257.0 COG3256@1|root,COG3256@2|Bacteria,1MVT1@1224|Proteobacteria,2VHXU@28216|Betaproteobacteria,44WAP@713636|Nitrosomonadales 28216|Betaproteobacteria C PFAM cytochrome c oxidase subunit I norB - 1.7.2.5 ko:K04561 ko00910,ko01120,map00910,map01120 M00529 R00294 RC02794 ko00000,ko00001,ko00002,ko01000 3.D.4.10 - - COX1 k59_608123_1 1238190.AMQY01000023_gene501 9.15e-13 67.8 COG3118@1|root,COG3118@2|Bacteria,1MV0R@1224|Proteobacteria,1RMSQ@1236|Gammaproteobacteria,1XJCT@135619|Oceanospirillales 135619|Oceanospirillales O Thioredoxin domain-containing protein trx-1 - - ko:K05838 - - - - ko00000,ko03110 - - - TPR_19,TPR_20,Thioredoxin k59_608123_2 243090.RB11146 2.22e-42 147.0 COG0412@1|root,COG0412@2|Bacteria 2|Bacteria Q carboxymethylenebutenolidase activity - - 3.1.1.45 ko:K01061 ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130 - R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222 RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686 ko00000,ko00001,ko01000 - - - DLH k59_268504_1 469383.Cwoe_1476 2.86e-08 61.6 COG0477@1|root,COG0477@2|Bacteria,2GIUM@201174|Actinobacteria 201174|Actinobacteria EGP Major facilitator superfamily - - - - - - - - - - - - MFS_1,Sugar_tr k59_1227376_1 1134912.AJTV01000015_gene320 2.46e-87 274.0 COG0374@1|root,COG0374@2|Bacteria,1MWFJ@1224|Proteobacteria,2TSH1@28211|Alphaproteobacteria,36X2D@31993|Methylocystaceae 28211|Alphaproteobacteria C Nickel-dependent hydrogenase hupL GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 1.12.99.6 ko:K06281 ko00633,ko01120,map00633,map01120 - R08034 RC00250 ko00000,ko00001,ko01000 - - - NiFeSe_Hases k59_153561_1 1144275.COCOR_08084 2.69e-70 236.0 COG0612@1|root,COG0612@2|Bacteria,1MVST@1224|Proteobacteria,42NYP@68525|delta/epsilon subdivisions,2WIPJ@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Belongs to the peptidase M16 family - - - ko:K07263 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M16,Peptidase_M16_C k59_942406_1 1197477.IA57_07695 3.77e-115 350.0 COG1185@1|root,COG1185@2|Bacteria,4NE4Q@976|Bacteroidetes,1HWNZ@117743|Flavobacteriia 976|Bacteroidetes J Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction pnp - 2.7.7.8 ko:K00962 ko00230,ko00240,ko03018,map00230,map00240,map03018 M00394 R00437,R00438,R00439,R00440 RC02795 ko00000,ko00001,ko00002,ko01000,ko03016,ko03019 - - - KH_1,PNPase,RNase_PH,RNase_PH_C,S1 k59_608136_1 1111728.ATYS01000014_gene4799 1.02e-84 261.0 COG0189@1|root,COG0189@2|Bacteria,1MVUA@1224|Proteobacteria,1RMU0@1236|Gammaproteobacteria 1236|Gammaproteobacteria H Belongs to the prokaryotic GSH synthase family gshB GO:0000287,GO:0003674,GO:0003824,GO:0004363,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006518,GO:0006575,GO:0006749,GO:0006750,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0019184,GO:0034641,GO:0042398,GO:0043043,GO:0043167,GO:0043169,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0051186,GO:0051188,GO:0071704,GO:1901564,GO:1901566,GO:1901576 6.3.2.3 ko:K01920 ko00270,ko00480,ko01100,map00270,map00480,map01100 M00118 R00497,R10994 RC00096,RC00141 ko00000,ko00001,ko00002,ko01000 - - iECED1_1282.ECED1_3410,iECP_1309.ECP_2941 GSH-S_ATP,GSH-S_N k59_383214_1 565045.NOR51B_599 1.84e-07 55.1 COG0477@1|root,COG2814@2|Bacteria,1QKNX@1224|Proteobacteria,1RSAI@1236|Gammaproteobacteria 1236|Gammaproteobacteria EGP Major Facilitator - - - - - - - - - - - - MFS_1 k59_383214_2 109760.SPPG_08068T0 5.51e-111 337.0 COG1012@1|root,KOG2451@2759|Eukaryota,38D8C@33154|Opisthokonta,3NVW2@4751|Fungi 4751|Fungi E Belongs to the aldehyde dehydrogenase family - - 1.2.1.16,1.2.1.20,1.2.1.79 ko:K00135 ko00250,ko00310,ko00350,ko00650,ko00760,ko01100,ko01120,map00250,map00310,map00350,map00650,map00760,map01100,map01120 M00027 R00713,R00714,R02401 RC00080 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_1451014_1 882082.SaccyDRAFT_3811 6.09e-63 211.0 COG4626@1|root,COG4626@2|Bacteria,2IB7D@201174|Actinobacteria,4E8SB@85010|Pseudonocardiales 201174|Actinobacteria S Terminase - - - - - - - - - - - - Terminase_1 k59_545244_1 1502852.FG94_04962 1.08e-25 103.0 2E6IB@1|root,3315H@2|Bacteria,1NAH0@1224|Proteobacteria,2W57Y@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_891553_1 553385.JEMF01000017_gene1146 1.13e-72 228.0 COG0225@1|root,COG0225@2|Bacteria,1R33Z@1224|Proteobacteria,1T62V@1236|Gammaproteobacteria,1XS2N@135619|Oceanospirillales 135619|Oceanospirillales O Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine - - 1.8.4.11 ko:K07304 - - - - ko00000,ko01000 - - - PMSR k59_942412_1 1150621.SMUL_1182 5.67e-61 207.0 COG0475@1|root,COG1226@1|root,COG0475@2|Bacteria,COG1226@2|Bacteria,1MV34@1224|Proteobacteria,42MEM@68525|delta/epsilon subdivisions,2YR9B@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family - - - - - - - - - - - - Na_H_Exchanger,TrkA_N k59_942412_2 1122137.AQXF01000006_gene801 4.64e-25 102.0 COG2939@1|root,COG2939@2|Bacteria,1MW05@1224|Proteobacteria,2TS7R@28211|Alphaproteobacteria 28211|Alphaproteobacteria E PFAM peptidase S10 serine carboxypeptidase - - - - - - - - - - - - Peptidase_S10 k59_1677747_1 1545915.JROG01000003_gene670 1.97e-97 288.0 COG0603@1|root,COG0603@2|Bacteria,1MU5V@1224|Proteobacteria,2TU7F@28211|Alphaproteobacteria,2K0K0@204457|Sphingomonadales 204457|Sphingomonadales F Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) queC - 6.3.4.20 ko:K06920 ko00790,ko01100,map00790,map01100 - R09978 RC00959 ko00000,ko00001,ko01000,ko03016 - - - QueC k59_1677747_2 1096930.L284_03690 2.03e-14 69.3 2AI43@1|root,318I3@2|Bacteria,1NCMB@1224|Proteobacteria,2UFPI@28211|Alphaproteobacteria,2K76K@204457|Sphingomonadales 204457|Sphingomonadales - - - - - - - - - - - - - - - k59_490133_1 436308.Nmar_0444 3.18e-110 337.0 COG1215@1|root,arCOG01389@2157|Archaea,41SDD@651137|Thaumarchaeota 651137|Thaumarchaeota M Glycosyl transferase family group 2 - - - - - - - - - - - - Glyco_tranf_2_3 k59_1735528_2 291985.CCSI01000007_gene512 6.62e-51 179.0 COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,2TRJF@28211|Alphaproteobacteria,2K1KW@204457|Sphingomonadales 204457|Sphingomonadales L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity polA - 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1 k59_434428_1 1122138.AQUZ01000004_gene888 7.14e-52 182.0 COG1053@1|root,COG1053@2|Bacteria,2GJ45@201174|Actinobacteria,4DPTE@85009|Propionibacteriales 201174|Actinobacteria C PFAM fumarate reductase succinate dehydrogenase flavoprotein domain protein frdA GO:0000104,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006091,GO:0006113,GO:0008150,GO:0008152,GO:0009055,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016627,GO:0022900,GO:0032991,GO:0044237,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0045273,GO:0045274,GO:0045283,GO:0045284,GO:0045333,GO:0055114,GO:0070469,GO:0070470,GO:0071944,GO:0098796,GO:0098797,GO:0098803 1.3.5.1,1.3.5.4,1.4.3.16 ko:K00239,ko:K00244,ko:K00278 ko00020,ko00190,ko00250,ko00620,ko00650,ko00720,ko00760,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,ko05134,map00020,map00190,map00250,map00620,map00650,map00720,map00760,map01100,map01110,map01120,map01130,map01200,map02020,map05134 M00009,M00011,M00115,M00149,M00150,M00173,M00374,M00376 R00357,R00481,R02164 RC00006,RC00045,RC02566 ko00000,ko00001,ko00002,ko01000 - - iNJ661.Rv1552 FAD_binding_2,Succ_DH_flav_C k59_1622836_1 436308.Nmar_1528 5.96e-23 102.0 arCOG07561@1|root,arCOG07561@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - TSP_3,VWA k59_1112426_1 396588.Tgr7_0332 2.92e-80 248.0 COG0702@1|root,COG0702@2|Bacteria,1MW54@1224|Proteobacteria,1RNS7@1236|Gammaproteobacteria,1WXE7@135613|Chromatiales 135613|Chromatiales GM NAD-dependent epimerase dehydratase - - 1.6.5.3,1.6.99.3 ko:K00329,ko:K00356 ko00190,map00190 - R11945 RC00061 ko00000,ko00001,ko01000 - - - Epimerase,NAD_binding_10 k59_608178_1 485918.Cpin_2993 4.46e-12 75.1 COG0265@1|root,COG0265@2|Bacteria,4P64A@976|Bacteroidetes 2|Bacteria O Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain M1-674 - 3.4.21.107 ko:K01173,ko:K04771 ko01503,ko02020,ko04210,map01503,map02020,map04210 M00728 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03029,ko03110 - - - Trypsin,Trypsin_2 k59_1787727_1 436308.Nmar_1635 8.52e-18 80.1 COG0705@1|root,arCOG01768@2157|Archaea,41SKD@651137|Thaumarchaeota 651137|Thaumarchaeota E Rhomboid family - - - - - - - - - - - - Rhomboid k59_831161_1 1313172.YM304_14720 5.68e-73 238.0 COG1770@1|root,COG1770@2|Bacteria,2GNA9@201174|Actinobacteria,4CMWJ@84992|Acidimicrobiia 84992|Acidimicrobiia E Prolyl oligopeptidase, N-terminal beta-propeller domain ptrB - 3.4.21.83 ko:K01354 ko05142,ko05143,map05142,map05143 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_S9,Peptidase_S9_N k59_1337700_1 1267005.KB911255_gene3001 2.72e-54 176.0 COG1671@1|root,COG1671@2|Bacteria,1RCZA@1224|Proteobacteria,2U997@28211|Alphaproteobacteria,3N6Z1@45401|Hyphomicrobiaceae 28211|Alphaproteobacteria S Belongs to the UPF0178 family MA20_27470 - - ko:K09768 - - - - ko00000 - - - DUF188 k59_1337700_3 247634.GPB2148_560 3.13e-33 119.0 COG3686@1|root,COG3686@2|Bacteria,1RAEH@1224|Proteobacteria,1SERR@1236|Gammaproteobacteria,1JA48@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S MAPEG family - - - - - - - - - - - - MAPEG k59_721576_1 883077.HMPREF9241_01565 3.05e-15 78.6 COG0584@1|root,COG0584@2|Bacteria,2GJ5W@201174|Actinobacteria,4D464@85005|Actinomycetales 201174|Actinobacteria C Glycerophosphodiester phosphodiesterase family protein glpQ2 - 3.1.4.46 ko:K01126 ko00564,map00564 - R01030,R01470 RC00017,RC00425 ko00000,ko00001,ko01000 - - - GDPD k59_831167_1 575788.VS_II0230 4.95e-15 78.2 COG0657@1|root,COG0657@2|Bacteria,1RD8A@1224|Proteobacteria,1S3TH@1236|Gammaproteobacteria,1XYX6@135623|Vibrionales 135623|Vibrionales I Steryl acetyl hydrolase - - 3.1.1.83 ko:K14731 ko00903,ko00930,ko01220,map00903,map00930,map01220 - R03751,R06390,R06391,R06392,R06393 RC00713,RC00983,RC01505 ko00000,ko00001,ko01000 - - - Abhydrolase_3 k59_831167_2 1502850.FG91_00623 1.14e-26 108.0 COG4948@1|root,COG4948@2|Bacteria,1MW76@1224|Proteobacteria,2TR16@28211|Alphaproteobacteria,2K34I@204457|Sphingomonadales 204457|Sphingomonadales M Mandelate racemase muconate lactonizing enzyme - - - - - - - - - - - - MR_MLE_C,MR_MLE_N k59_831168_1 436308.Nmar_0849 2.5e-17 79.7 arCOG08708@1|root,arCOG08708@2157|Archaea,41SPK@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_383254_1 251221.35212131 1.2e-43 149.0 2AVYW@1|root,31MT4@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_1227459_1 1229780.BN381_20106 2.79e-104 336.0 COG1197@1|root,COG1197@2|Bacteria,2GJ42@201174|Actinobacteria,3UW8A@52018|unclassified Actinobacteria (class) 201174|Actinobacteria L Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site mfd GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944 - ko:K03723 ko03420,map03420 - - - ko00000,ko00001,ko01000,ko03400 - - - CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF k59_383262_1 1122137.AQXF01000002_gene92 1.42e-84 256.0 COG0767@1|root,COG0767@2|Bacteria,1MVPN@1224|Proteobacteria,2TSGS@28211|Alphaproteobacteria 28211|Alphaproteobacteria Q ABC-type transport system involved in resistance to organic solvents permease component mlaE - - ko:K02066 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - MlaE k59_383262_2 1380391.JIAS01000017_gene659 2.33e-84 256.0 COG1127@1|root,COG1127@2|Bacteria,1MUSD@1224|Proteobacteria,2TR2I@28211|Alphaproteobacteria,2JQ66@204441|Rhodospirillales 204441|Rhodospirillales Q COG1127 ABC-type transport system involved in resistance to organic solvents, ATPase component mkl - - ko:K02065 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - ABC_tran k59_942463_2 436308.Nmar_0749 5.95e-28 108.0 arCOG10540@1|root,arCOG10540@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_1112452_1 1121017.AUFG01000002_gene2723 1.31e-12 74.7 COG0508@1|root,COG0508@2|Bacteria,2GM0D@201174|Actinobacteria,4FFEF@85021|Intrasporangiaceae 201174|Actinobacteria C Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex pdhC - 2.3.1.12 ko:K00627 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200 M00307 R00209,R02569 RC00004,RC02742,RC02857 br01601,ko00000,ko00001,ko00002,ko01000 - - - 2-oxoacid_dh,Biotin_lipoyl,E3_binding k59_1112452_2 1048339.KB913029_gene961 3.31e-23 100.0 COG0022@1|root,COG0022@2|Bacteria,2GKFE@201174|Actinobacteria,4ESHW@85013|Frankiales 201174|Actinobacteria C PFAM Transketolase central region acoB - 1.2.4.1,1.2.4.4 ko:K00162,ko:K11381,ko:K21417 ko00010,ko00020,ko00280,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00280,map00620,map00640,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230 M00036,M00307 R00014,R00209,R01699,R03270,R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997 RC00004,RC00027,RC00627,RC02742,RC02743,RC02744,RC02882,RC02883,RC02949,RC02953 br01601,ko00000,ko00001,ko00002,ko01000 - - - E1_dh,Transket_pyr,Transketolase_C k59_153673_1 697282.Mettu_2892 3.97e-30 115.0 COG2825@1|root,COG2825@2|Bacteria,1RD8X@1224|Proteobacteria,1RQIE@1236|Gammaproteobacteria,1XF7V@135618|Methylococcales 135618|Methylococcales M Belongs to the skp family - - - ko:K06142 - - - - ko00000 - - - OmpH k59_1677800_1 1280944.HY17_10325 3.7e-53 181.0 COG0845@1|root,COG0845@2|Bacteria,1Q10W@1224|Proteobacteria,2TSC8@28211|Alphaproteobacteria,43ZAU@69657|Hyphomonadaceae 28211|Alphaproteobacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - ko:K02005 - - - - ko00000 - - - HlyD_3 k59_153676_1 582744.Msip34_1003 1.3e-38 140.0 COG1230@1|root,COG1230@2|Bacteria,1QUZ5@1224|Proteobacteria,2WGMK@28216|Betaproteobacteria,2KMTU@206350|Nitrosomonadales 206350|Nitrosomonadales P TIGRFAM cation diffusion facilitator family transporter - - - ko:K16264 - - - - ko00000,ko02000 2.A.4.1 - - Cation_efflux k59_1622890_1 1121441.AUCX01000010_gene233 4.3e-59 194.0 COG1127@1|root,COG1127@2|Bacteria,1MUSD@1224|Proteobacteria,42NI4@68525|delta/epsilon subdivisions,2WKRT@28221|Deltaproteobacteria,2M854@213115|Desulfovibrionales 28221|Deltaproteobacteria Q PFAM ABC transporter related - - - ko:K02065 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - ABC_tran k59_1451108_1 545276.KB898725_gene803 7.41e-101 305.0 COG0137@1|root,COG0137@2|Bacteria,1MV0Y@1224|Proteobacteria,1RMEC@1236|Gammaproteobacteria,1WXPT@135613|Chromatiales 135613|Chromatiales E Belongs to the argininosuccinate synthase family. Type 1 subfamily argG - 6.3.4.5 ko:K01940 ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418 M00029,M00844,M00845 R01954 RC00380,RC00629 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Arginosuc_synth k59_1570312_1 1122137.AQXF01000001_gene3165 3.44e-114 338.0 COG0702@1|root,COG0702@2|Bacteria,1MW54@1224|Proteobacteria,2TQMD@28211|Alphaproteobacteria 28211|Alphaproteobacteria GM 3-beta hydroxysteroid dehydrogenase MA20_24380 - 1.6.5.3,1.6.99.3 ko:K00329,ko:K00356 ko00190,map00190 - R11945 RC00061 ko00000,ko00001,ko01000 - - - 3Beta_HSD,Epimerase,NAD_binding_10,RmlD_sub_bind k59_1622897_1 46429.BV95_00317 9.34e-72 227.0 COG1566@1|root,COG1566@2|Bacteria,1QU7Z@1224|Proteobacteria,2TW9Z@28211|Alphaproteobacteria,2K9Q8@204457|Sphingomonadales 204457|Sphingomonadales V Biotin-lipoyl like - - - ko:K01993 - - - - ko00000 - - - - k59_1400118_1 1333998.M2A_1599 1.74e-37 142.0 COG0477@1|root,COG2814@2|Bacteria,1RAYJ@1224|Proteobacteria,2UNRX@28211|Alphaproteobacteria 28211|Alphaproteobacteria EGP Transmembrane secretion effector - - - - - - - - - - - - MFS_1 k59_1112482_1 1121035.AUCH01000001_gene1803 1.88e-51 179.0 COG1185@1|root,COG1185@2|Bacteria,1MVB9@1224|Proteobacteria,2VI1P@28216|Betaproteobacteria,2KUVE@206389|Rhodocyclales 206389|Rhodocyclales J Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction pnp - 2.7.7.8 ko:K00962 ko00230,ko00240,ko03018,map00230,map00240,map03018 M00394 R00437,R00438,R00439,R00440 RC02795 ko00000,ko00001,ko00002,ko01000,ko03016,ko03019 - - - KH_1,PNPase,RNase_PH,RNase_PH_C,S1 k59_1112482_2 904144.AEJD01000005_gene294 3.41e-24 93.6 COG0184@1|root,COG0184@2|Bacteria,2IQA0@201174|Actinobacteria,4D10E@85004|Bifidobacteriales 201174|Actinobacteria J Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome rpsO GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0015935,GO:0016020,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071944,GO:1990904 - ko:K02956 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S15 k59_545359_2 335543.Sfum_3241 6.98e-55 177.0 arCOG05253@1|root,31CTK@2|Bacteria,1RIYS@1224|Proteobacteria,42T7T@68525|delta/epsilon subdivisions,2WP9R@28221|Deltaproteobacteria,2MQHS@213462|Syntrophobacterales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_210955_1 1131266.ARWQ01000002_gene696 2.85e-49 162.0 COG3467@1|root,arCOG00520@2157|Archaea,41SJ5@651137|Thaumarchaeota 651137|Thaumarchaeota S Pyridoxamine 5'-phosphate - - - ko:K07005 - - - - ko00000 - - - Pyridox_ox_2 k59_210955_2 436308.Nmar_1107 2.59e-09 55.5 arCOG10575@1|root,arCOG10575@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_1337751_1 702113.PP1Y_AT24898 8.7e-115 338.0 COG0505@1|root,COG0505@2|Bacteria,1MUB9@1224|Proteobacteria,2TR3W@28211|Alphaproteobacteria,2K02X@204457|Sphingomonadales 204457|Sphingomonadales F Belongs to the CarA family carA - 6.3.5.5 ko:K01956 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - - CPSase_sm_chain,GATase k59_1677830_1 1122137.AQXF01000002_gene135 9.08e-75 232.0 COG0264@1|root,COG0264@2|Bacteria,1MUS2@1224|Proteobacteria,2TQM0@28211|Alphaproteobacteria 28211|Alphaproteobacteria J Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome tsf GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - ko:K02357 - - - - ko00000,ko03012,ko03029 - - - EF_TS k59_1677830_2 759362.KVU_0597 4.92e-25 99.8 COG0528@1|root,COG0528@2|Bacteria,1MV3N@1224|Proteobacteria,2TQYN@28211|Alphaproteobacteria 28211|Alphaproteobacteria F Catalyzes the reversible phosphorylation of UMP to UDP pyrH - 2.7.4.22 ko:K09903 ko00240,ko01100,map00240,map01100 - R00158 RC00002 ko00000,ko00001,ko01000 - - - AA_kinase k59_660893_1 1144305.PMI02_05207 1.38e-12 66.2 COG1253@1|root,COG1253@2|Bacteria,1MV3P@1224|Proteobacteria,2TVFA@28211|Alphaproteobacteria,2K03F@204457|Sphingomonadales 204457|Sphingomonadales S COG1253 Hemolysins and related proteins containing CBS domains - - - - - - - - - - - - CBS,CorC_HlyC k59_660893_2 1088721.NSU_2179 5.64e-80 243.0 COG0583@1|root,COG0583@2|Bacteria,1R69A@1224|Proteobacteria,2U1WB@28211|Alphaproteobacteria,2K166@204457|Sphingomonadales 204457|Sphingomonadales K Transcriptional regulator - - - ko:K03566 ko02026,map02026 - - - ko00000,ko00001,ko03000 - - - HTH_1,LysR_substrate k59_210964_1 314230.DSM3645_24812 1.1e-62 212.0 COG2204@1|root,COG2204@2|Bacteria,2IY6A@203682|Planctomycetes 203682|Planctomycetes T Ornithine decarboxylase inhibitor-putative sigma54 transciptional regulator - - - ko:K02584 ko02020,map02020 - - - ko00000,ko00001,ko03000 - - - FHA,GAF,GAF_2,HTH_8,Sigma54_activat k59_1227527_1 159087.Daro_1317 1.65e-90 280.0 COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,2WEDQ@28216|Betaproteobacteria,2KUKA@206389|Rhodocyclales 206389|Rhodocyclales P COG0601 ABC-type dipeptide oligopeptide nickel transport systems, permease components oppB - - ko:K02033 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1 k59_1112497_1 745718.JADT01000019_gene1503 2.71e-115 355.0 COG0542@1|root,COG0542@2|Bacteria,4NE1J@976|Bacteroidetes,1HWVR@117743|Flavobacteriia 976|Bacteroidetes O Belongs to the ClpA ClpB family clpC - - ko:K03696 ko01100,map01100 - - - ko00000,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N,UVR k59_721625_1 1279017.AQYJ01000026_gene57 1.35e-41 156.0 COG1360@1|root,COG2885@1|root,COG1360@2|Bacteria,COG2885@2|Bacteria,1QW22@1224|Proteobacteria,1T4AK@1236|Gammaproteobacteria,46ACU@72275|Alteromonadaceae 1236|Gammaproteobacteria M OmpA family - - - - - - - - - - - - DUF11,OmpA k59_1227532_1 63737.Npun_R6612 1.47e-39 154.0 COG1672@1|root,COG2319@1|root,COG3064@1|root,COG1672@2|Bacteria,COG2319@2|Bacteria,COG3064@2|Bacteria,1FZVW@1117|Cyanobacteria,1HMFW@1161|Nostocales 1117|Cyanobacteria M repeat-containing protein - - - - - - - - - - - - AAA_35,WD40 k59_490223_2 1415779.JOMH01000001_gene183 2.43e-26 109.0 28MBM@1|root,2ZAQ2@2|Bacteria,1R5V6@1224|Proteobacteria,1S0K0@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_268610_1 931627.MycrhDRAFT_4012 1.59e-31 121.0 COG0518@1|root,COG0518@2|Bacteria,2GNA6@201174|Actinobacteria,234I4@1762|Mycobacteriaceae 201174|Actinobacteria F glutamine amidotransferase - - - - - - - - - - - - GATase k59_1451157_1 666685.R2APBS1_3946 1.5e-05 47.0 COG1577@1|root,COG1577@2|Bacteria,1N400@1224|Proteobacteria,1SC29@1236|Gammaproteobacteria,1XAB2@135614|Xanthomonadales 135614|Xanthomonadales I GHMP kinases N terminal domain - - 2.7.4.2 ko:K00938 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00095 R03245 RC00002 ko00000,ko00001,ko00002,ko01000 - - - GHMP_kinases_N k59_1451157_2 666685.R2APBS1_3945 7.78e-69 223.0 COG3407@1|root,COG3407@2|Bacteria,1N5EZ@1224|Proteobacteria,1S19T@1236|Gammaproteobacteria,1X9HF@135614|Xanthomonadales 135614|Xanthomonadales I GHMP kinases N terminal domain - - 4.1.1.33 ko:K01597 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00095 R01121 RC00453 ko00000,ko00001,ko00002,ko01000 - - - GHMP_kinases_N k59_490225_1 365044.Pnap_3762 6.13e-26 106.0 COG2223@1|root,COG2223@2|Bacteria,1MU27@1224|Proteobacteria,2VI5E@28216|Betaproteobacteria,4ABQV@80864|Comamonadaceae 28216|Betaproteobacteria P nitrite transporter - - - ko:K02575 ko00910,map00910 M00615 - - ko00000,ko00001,ko00002,ko02000 2.A.1.8 - - MFS_1 k59_1677859_1 316407.1651487 3.71e-78 236.0 COG0745@1|root,COG0745@2|Bacteria,1MWJG@1224|Proteobacteria,1RPU3@1236|Gammaproteobacteria,3XM4X@561|Escherichia 1236|Gammaproteobacteria K Member of the two-component regulatory system TorS TorR involved in the anaerobic utilization of trimethylamine-N-oxide (TMAO). Phosphorylated TorR activates the transcription of the torCAD operon by binding to four decameric boxes located in the torCAD promoter. Box1, 2 and 4 contain the DNA sequence 5'- CTGTTCATAT-3' and box3 contains the DNA sequence 5'-CCGTTCATCC-3'. Phosphorylated as well as unphosphorylated TorR negatively regulates its own expression by binding to box1 and 2 torR GO:0000156,GO:0000160,GO:0003674,GO:0006355,GO:0007154,GO:0007165,GO:0008150,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0023052,GO:0031323,GO:0031326,GO:0035556,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0051716,GO:0060089,GO:0060255,GO:0065007,GO:0080090,GO:1903506,GO:2000112,GO:2001141 - ko:K02483,ko:K07772 ko02020,map02020 M00455 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Trans_reg_C k59_1677859_2 316407.4062711 1.01e-39 140.0 COG1879@1|root,COG1879@2|Bacteria,1MXQN@1224|Proteobacteria,1S0HG@1236|Gammaproteobacteria,3XPG5@561|Escherichia 1236|Gammaproteobacteria G inducer it probably interacts with TorS and allows it to play a role in the induction of the torCAD operon for trimethylamine N-oxide reductase torT GO:0005575,GO:0005623,GO:0042597,GO:0044464 - ko:K11930 - - - - ko00000 - - - Peripla_BP_1 k59_1570356_1 1502770.JQMG01000001_gene570 2.96e-35 134.0 COG0826@1|root,COG0826@2|Bacteria,1MUQG@1224|Proteobacteria,2VH51@28216|Betaproteobacteria,2KNDU@206350|Nitrosomonadales 206350|Nitrosomonadales O Peptidase family U32 C-terminal domain - - - ko:K08303 ko05120,map05120 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_U32,Peptidase_U32_C k59_434542_1 316407.85676948 5.2e-139 396.0 COG3623@1|root,COG3623@2|Bacteria,1MWTD@1224|Proteobacteria,1RPT6@1236|Gammaproteobacteria,3XNDK@561|Escherichia 1236|Gammaproteobacteria G Catalyzes the isomerization of L-xylulose-5-phosphate to L-ribulose-5-phosphate. Is involved in the anaerobic L-ascorbate utilization ulaE GO:0003674,GO:0003824,GO:0005975,GO:0005996,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0008150,GO:0008152,GO:0009987,GO:0016853,GO:0016854,GO:0016857,GO:0019752,GO:0019852,GO:0034015,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0051186,GO:0071704 5.1.3.22 ko:K03079 ko00040,ko00053,ko01100,ko01120,map00040,map00053,map01100,map01120 M00550 R03244 RC00540 ko00000,ko00001,ko00002,ko01000 - - iEC55989_1330.EC55989_4754,iECSE_1348.ECSE_4495,iEcHS_1320.EcHS_A4441,iEcSMS35_1347.EcSMS35_4668,iYL1228.KPN_04590 AP_endonuc_2 k59_153731_1 316407.85675530 1.73e-106 320.0 COG3604@1|root,COG3604@2|Bacteria,1QTT3@1224|Proteobacteria,1T1G7@1236|Gammaproteobacteria,3XMM3@561|Escherichia 1236|Gammaproteobacteria K Required for the expression of anaerobic nitric oxide (NO) reductase, acts as a transcriptional activator for at least the norVW operon. Activation also requires sigma-54 norR GO:0000976,GO:0000984,GO:0001017,GO:0001067,GO:0001130,GO:0001150,GO:0001151,GO:0001158,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005506,GO:0005515,GO:0006355,GO:0008150,GO:0008198,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031334,GO:0035326,GO:0042802,GO:0043167,GO:0043169,GO:0043254,GO:0043565,GO:0044087,GO:0044089,GO:0044212,GO:0045893,GO:0045935,GO:0046872,GO:0046914,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051128,GO:0051130,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0070026,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2000142,GO:2000144,GO:2001141 - ko:K12266 ko05132,map05132 - - - ko00000,ko00001,ko03000 - - - GAF,Sigma54_activat k59_999506_2 983920.Y88_2735 1.3e-80 254.0 COG0374@1|root,COG0374@2|Bacteria,1MWFJ@1224|Proteobacteria,2TSPU@28211|Alphaproteobacteria 28211|Alphaproteobacteria C Large subunit hupV - 1.12.99.6 ko:K06281 ko00633,ko01120,map00633,map01120 - R08034 RC00250 ko00000,ko00001,ko01000 - - - NiFeSe_Hases k59_1282249_1 316407.85675935 4.3e-74 228.0 COG3715@1|root,COG3715@2|Bacteria,1R5G0@1224|Proteobacteria,1RZTN@1236|Gammaproteobacteria,3XPEE@561|Escherichia 1236|Gammaproteobacteria G PTS system N-acetylgalactosamine-specific agaC GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0008643,GO:0009401,GO:0015144,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034219,GO:0044425,GO:0044459,GO:0044464,GO:0051119,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944 - ko:K10985 ko00052,ko02060,map00052,map02060 M00287 R08367 RC00017,RC03206 ko00000,ko00001,ko00002,ko02000 4.A.6.1.5 - - EII-Sor k59_1282249_2 316407.85675934 8.97e-108 310.0 COG3444@1|root,COG3444@2|Bacteria,1R4ES@1224|Proteobacteria,1RWA2@1236|Gammaproteobacteria,3XMC9@561|Escherichia 1236|Gammaproteobacteria G IIB component agaB - - ko:K10984 ko00052,ko02060,map00052,map02060 M00287 R08367 RC00017,RC03206 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.6.1.5 - iB21_1397.B21_02956,iEC55989_1330.EC55989_3558,iECBD_1354.ECBD_0602,iECB_1328.ECB_03005,iECD_1391.ECD_03005,iECIAI1_1343.ECIAI1_3288,iECIAI39_1322.ECIAI39_3639,iECO103_1326.ECO103_3885,iECO111_1330.ECO111_3962,iECO26_1355.ECO26_4243,iECSE_1348.ECSE_3424,iECW_1372.ECW_m3408,iEKO11_1354.EKO11_0579,iEcE24377_1341.EcE24377A_3620,iEcSMS35_1347.EcSMS35_3437,iEcolC_1368.EcolC_0560,iUMNK88_1353.UMNK88_3897,iWFL_1372.ECW_m3408 PTSIIB_sorb k59_892595_1 1122137.AQXF01000002_gene249 2.8e-222 640.0 COG0188@1|root,COG0188@2|Bacteria,1MUGG@1224|Proteobacteria,2TSPQ@28211|Alphaproteobacteria 28211|Alphaproteobacteria L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrA - 5.99.1.3 ko:K02469 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseA_C,DNA_topoisoIV k59_901046_1 1437425.CSEC_1493 8.5e-26 105.0 COG3868@1|root,COG3868@2|Bacteria 2|Bacteria S Glycoside-hydrolase family GH114 - - - ko:K21006 ko02025,map02025 - - - ko00000,ko00001 - - - Glyco_hydro_114 k59_781305_1 1117647.M5M_18165 2.18e-69 216.0 28I6Z@1|root,2Z89U@2|Bacteria,1R8YM@1224|Proteobacteria,1S0GG@1236|Gammaproteobacteria 1236|Gammaproteobacteria S von Willebrand factor (vWF) type A domain - - - - - - - - - - - - - k59_617899_1 1385518.N798_05235 1.42e-17 87.8 COG2132@1|root,COG2132@2|Bacteria,2ICI4@201174|Actinobacteria,4FIU6@85021|Intrasporangiaceae 201174|Actinobacteria Q Multicopper oxidase - - - - - - - - - - - - Cu-oxidase_2 k59_1632331_1 1045856.EcWSU1_03203 1.43e-36 143.0 COG0665@1|root,COG4121@1|root,COG0665@2|Bacteria,COG4121@2|Bacteria,1MZW5@1224|Proteobacteria,1RMTE@1236|Gammaproteobacteria,3X1ZP@547|Enterobacter 1236|Gammaproteobacteria H Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 mnmC GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0003824,GO:0004808,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016491,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0055114,GO:0071704,GO:0071949,GO:0090304,GO:0097159,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363 2.1.1.61 ko:K15461 - - R00601,R08702 RC00003,RC00053,RC00060,RC01483 ko00000,ko01000,ko03016 - - - DAO,Methyltransf_30 k59_335781_1 1117647.M5M_17595 2.83e-105 317.0 COG0766@1|root,COG0766@2|Bacteria,1MUH7@1224|Proteobacteria,1RN91@1236|Gammaproteobacteria,1J56Z@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Belongs to the EPSP synthase family. MurA subfamily murA GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008760,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016740,GO:0016765,GO:0030203,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 2.5.1.7 ko:K00790 ko00520,ko00550,ko01100,map00520,map00550,map01100 - R00660 RC00350 ko00000,ko00001,ko01000,ko01011 - - - EPSP_synthase k59_781309_1 1123367.C666_05015 1.38e-20 89.4 2DBUZ@1|root,2ZB8W@2|Bacteria,1QWGF@1224|Proteobacteria,2VM8U@28216|Betaproteobacteria,2KVDM@206389|Rhodocyclales 206389|Rhodocyclales - - - - - - - - - - - - - - - k59_781309_2 1049564.TevJSym_ac00110 5.67e-44 148.0 COG2863@1|root,COG2863@2|Bacteria,1R6DK@1224|Proteobacteria 1224|Proteobacteria C Pfam cytochrome c - - - - - - - - - - - - Cytochrom_C k59_1347120_1 1121943.KB900003_gene2863 1.02e-17 85.5 COG0477@1|root,COG2814@2|Bacteria,1MVSH@1224|Proteobacteria,1RN70@1236|Gammaproteobacteria,1XHXW@135619|Oceanospirillales 135619|Oceanospirillales EGP Major facilitator superfamily - - - - - - - - - - - - MFS_1,Sugar_tr k59_1347120_2 1453501.JELR01000005_gene1754 5.84e-70 215.0 COG0629@1|root,COG0629@2|Bacteria,1RCWT@1224|Proteobacteria,1S3WP@1236|Gammaproteobacteria,466WC@72275|Alteromonadaceae 1236|Gammaproteobacteria L Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism ssb - - ko:K03111 ko03030,ko03430,ko03440,map03030,map03430,map03440 - - - ko00000,ko00001,ko03029,ko03032,ko03400 - - - SSB k59_781327_1 1283300.ATXB01000001_gene157 4.71e-54 180.0 COG0189@1|root,COG0189@2|Bacteria,1MVDU@1224|Proteobacteria,1RR7D@1236|Gammaproteobacteria,1XG64@135618|Methylococcales 135618|Methylococcales HJ Sugar-transfer associated ATP-grasp - - - - - - - - - - - - ATPgrasp_ST k59_617914_1 243090.RB12526 4.8e-37 136.0 COG0705@1|root,COG0705@2|Bacteria,2IZZY@203682|Planctomycetes 203682|Planctomycetes S PFAM Rhomboid family - - - - - - - - - - - - Rhomboid k59_1687597_1 1280950.HJO_02715 2.6e-06 49.7 COG2124@1|root,COG2124@2|Bacteria,1MY5H@1224|Proteobacteria,2TR6X@28211|Alphaproteobacteria 28211|Alphaproteobacteria Q Cytochrome P450 MA20_16575 - - - - - - - - - - - p450 k59_1687597_2 1168065.DOK_06984 9.99e-41 143.0 COG0451@1|root,COG0451@2|Bacteria,1NM1U@1224|Proteobacteria,1S0VN@1236|Gammaproteobacteria,1J5IN@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria GM NAD dependent epimerase/dehydratase family - - - - - - - - - - - - Epimerase k59_1347126_1 1380394.JADL01000001_gene2870 8.07e-07 52.0 COG3703@1|root,COG3703@2|Bacteria,1QA7D@1224|Proteobacteria,2U7C6@28211|Alphaproteobacteria,2JSNY@204441|Rhodospirillales 204441|Rhodospirillales P Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides chaC - - ko:K07232 - - - - ko00000 - - - ChaC k59_1347126_2 1540221.JQNI01000002_gene1348 2.65e-11 66.2 COG1168@1|root,COG1168@2|Bacteria,1WI5E@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus E Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities - - 4.4.1.8 ko:K14155 ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230 - R00782,R01286,R02408,R04941 RC00056,RC00069,RC00382,RC00488,RC00710,RC01245,RC02303 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_1_2 k59_108459_1 349124.Hhal_0651 2.05e-68 221.0 COG1066@1|root,COG1066@2|Bacteria,1MUJQ@1224|Proteobacteria,1RN2E@1236|Gammaproteobacteria,1WWW0@135613|Chromatiales 135613|Chromatiales O DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function radA - - ko:K04485 - - - - ko00000,ko03400 - - - AAA_25,ATPase,ChlI,Lon_C k59_554808_1 1042377.AFPJ01000024_gene710 6.25e-90 282.0 COG1154@1|root,COG1154@2|Bacteria,1MUSJ@1224|Proteobacteria,1RNQD@1236|Gammaproteobacteria,4651D@72275|Alteromonadaceae 1236|Gammaproteobacteria H Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) dxs GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006725,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008614,GO:0008615,GO:0008654,GO:0008661,GO:0009058,GO:0009108,GO:0009110,GO:0009228,GO:0009240,GO:0009987,GO:0016740,GO:0016744,GO:0017144,GO:0018130,GO:0019288,GO:0019438,GO:0019637,GO:0019682,GO:0019752,GO:0019842,GO:0030976,GO:0032787,GO:0034641,GO:0036094,GO:0042180,GO:0042181,GO:0042364,GO:0042723,GO:0042724,GO:0042816,GO:0042819,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046490,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0071704,GO:0072524,GO:0072525,GO:0072527,GO:0072528,GO:0090407,GO:0097159,GO:1901135,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617,GO:1901661,GO:1901663,GO:1901681 2.2.1.7 ko:K01662 ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130 M00096 R05636 RC00032 ko00000,ko00001,ko00002,ko01000 - - iEcSMS35_1347.EcSMS35_0456,iJN746.PP_0527 DXP_synthase_N,Transket_pyr,Transketolase_C k59_392887_1 745718.JADT01000017_gene1082 2.08e-124 385.0 COG1197@1|root,COG1197@2|Bacteria,4NEPA@976|Bacteroidetes,1HWS4@117743|Flavobacteriia 976|Bacteroidetes L Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site mfd - - ko:K03723 ko03420,map03420 - - - ko00000,ko00001,ko01000,ko03400 - - - CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF k59_1236186_1 59538.XP_005961372.1 9.82e-41 147.0 COG1012@1|root,KOG2450@2759|Eukaryota,38CDB@33154|Opisthokonta,3BCJG@33208|Metazoa,3CU6J@33213|Bilateria,48131@7711|Chordata,48WXF@7742|Vertebrata,3JC40@40674|Mammalia,4J35M@91561|Cetartiodactyla 33208|Metazoa C Aldehyde dehydrogenase - - 1.2.1.3 ko:K00128 ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130 M00135 R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146 RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_1236186_2 1207055.C100_18220 1.38e-22 94.7 COG0599@1|root,COG0599@2|Bacteria 2|Bacteria S peroxiredoxin activity rnhA - 3.1.26.4,4.1.1.44 ko:K01607,ko:K03469 ko00362,ko01100,ko01120,ko01220,ko03030,map00362,map01100,map01120,map01220,map03030 - R03470 RC00938 ko00000,ko00001,ko01000,ko03032 - - - CMD k59_781346_1 985255.APHJ01000019_gene532 2.57e-107 320.0 COG0520@1|root,COG0520@2|Bacteria,4NDUB@976|Bacteroidetes,1HWSI@117743|Flavobacteriia,2P62U@244698|Gillisia 976|Bacteroidetes E Cys/Met metabolism PLP-dependent enzyme sufS - 2.8.1.7,4.4.1.16 ko:K11717 ko00450,ko01100,map00450,map01100 - R03599,R11528 RC00961,RC01789,RC02313 ko00000,ko00001,ko01000 - - - Aminotran_5 k59_1291055_1 614083.AWQR01000028_gene3188 1.19e-44 149.0 COG0346@1|root,COG0346@2|Bacteria,1RI3Q@1224|Proteobacteria,2VSN7@28216|Betaproteobacteria,4AHZP@80864|Comamonadaceae 28216|Betaproteobacteria E glyoxalase bleomycin resistance protein dioxygenase - - - - - - - - - - - - Glyoxalase k59_1460708_1 66869.JNXG01000006_gene1780 2.02e-10 67.0 COG1020@1|root,COG1020@2|Bacteria,2GISR@201174|Actinobacteria,417CI@629295|Streptomyces griseus group 201174|Actinobacteria Q Condensation domain - - - - - - - - - - - - AMP-binding,AMP-binding_C,Condensation,PP-binding k59_669980_1 497965.Cyan7822_4182 3.92e-09 57.4 COG0745@1|root,COG0745@2|Bacteria,1G7WM@1117|Cyanobacteria,3KHZ3@43988|Cyanothece 1117|Cyanobacteria T Response regulator receiver - - - - - - - - - - - - Response_reg k59_669980_2 348824.LPU83_0760 1.34e-41 155.0 COG1807@1|root,COG3829@1|root,COG4251@1|root,COG1807@2|Bacteria,COG3829@2|Bacteria,COG4251@2|Bacteria,1NSQ1@1224|Proteobacteria,2UR9Y@28211|Alphaproteobacteria,4BNTR@82115|Rhizobiaceae 28211|Alphaproteobacteria T Histidine kinase - - - - - - - - - - - - HATPase_c,HisKA,PAS,PAS_9 k59_1291065_1 1234595.C725_0204 1.27e-56 186.0 COG1005@1|root,COG1005@2|Bacteria,1MU2R@1224|Proteobacteria,2TS09@28211|Alphaproteobacteria,4BPH0@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone nuoH GO:0003674,GO:0003824,GO:0003954,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0016655,GO:0050136,GO:0055114 1.6.5.3 ko:K00337 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - NADHdh k59_1291065_2 443598.AUFA01000003_gene2067 8.74e-07 51.6 COG1034@1|root,COG1034@2|Bacteria,1P8MN@1224|Proteobacteria,2TS97@28211|Alphaproteobacteria,3JSCC@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria C NADH-quinone oxidoreductase nuoG - 1.6.5.3 ko:K00336 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Fer2_4,Molybdopterin,NADH-G_4Fe-4S_3,NADH_dhqG_C k59_901083_1 358220.C380_02745 1.12e-32 124.0 COG3794@1|root,COG3794@2|Bacteria,1RHQU@1224|Proteobacteria,2VSJJ@28216|Betaproteobacteria,4AEGW@80864|Comamonadaceae 28216|Betaproteobacteria C PFAM blue (type 1) copper domain protein - - - - - - - - - - - - - k59_443810_1 702113.PP1Y_AT11591 5.04e-10 58.2 COG0346@1|root,COG0346@2|Bacteria,1N4DA@1224|Proteobacteria,2UEPZ@28211|Alphaproteobacteria,2K534@204457|Sphingomonadales 204457|Sphingomonadales E Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - - - - - - - - - - Glyoxalase k59_443810_2 467661.RKLH11_1596 5.48e-40 141.0 COG1028@1|root,COG1028@2|Bacteria,1RHYX@1224|Proteobacteria,2TUR9@28211|Alphaproteobacteria,3ZHF1@58840|unclassified Rhodobacteraceae 28211|Alphaproteobacteria IQ COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) csgA - - - - - - - - - - - adh_short k59_1744587_1 1122137.AQXF01000002_gene149 2.42e-28 111.0 COG0303@1|root,COG0303@2|Bacteria,1MVD5@1224|Proteobacteria,2TQRI@28211|Alphaproteobacteria 28211|Alphaproteobacteria H COG0303 Molybdopterin biosynthesis enzyme moeA - 2.10.1.1 ko:K03750 ko00790,ko01100,map00790,map01100 - R09735 RC03462 ko00000,ko00001,ko01000 - - - MoCF_biosynth,MoeA_C,MoeA_N k59_1744587_2 1122137.AQXF01000002_gene148 1.25e-50 167.0 COG1974@1|root,COG1974@2|Bacteria,1MW80@1224|Proteobacteria,2TT7W@28211|Alphaproteobacteria 28211|Alphaproteobacteria K Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair lexA GO:0000976,GO:0001067,GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0006355,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0009991,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0031668,GO:0032991,GO:0032993,GO:0033554,GO:0043565,GO:0044212,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0051716,GO:0060255,GO:0065007,GO:0071496,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2001141 3.4.21.88 ko:K01356 - M00729 - - ko00000,ko00002,ko01000,ko01002,ko03400 - - - LexA_DNA_bind,Peptidase_S24 k59_1522067_1 58123.JOFJ01000005_gene1275 4.68e-22 95.1 COG0842@1|root,COG0842@2|Bacteria,2IITR@201174|Actinobacteria,4EPFX@85012|Streptosporangiales 201174|Actinobacteria V ABC-2 type transporter - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane k59_1632405_1 103733.JNYO01000008_gene5470 3.8e-61 199.0 COG3866@1|root,COG3866@2|Bacteria,2H1QU@201174|Actinobacteria 201174|Actinobacteria G Amb_all - - - - - - - - - - - - Pec_lyase_C k59_1687625_1 1158292.JPOE01000005_gene58 9.4e-09 62.0 COG0810@1|root,COG0810@2|Bacteria,1MUMT@1224|Proteobacteria,2VKSW@28216|Betaproteobacteria,1KJAB@119065|unclassified Burkholderiales 28216|Betaproteobacteria M TonB C terminal - - - ko:K03832 - - - - ko00000,ko02000 2.C.1.1 - - TonB_2,TonB_C k59_951946_1 1120953.AUBH01000007_gene1877 3.04e-151 446.0 COG3590@1|root,COG3590@2|Bacteria,1MVNQ@1224|Proteobacteria,1RNNA@1236|Gammaproteobacteria,464DA@72275|Alteromonadaceae 1236|Gammaproteobacteria O Peptidase, M13 pepO - 3.4.24.71 ko:K01415,ko:K07386 - - - - ko00000,ko01000,ko01002,ko04147 - - - Peptidase_M13,Peptidase_M13_N k59_951946_2 765910.MARPU_02975 2.7e-28 110.0 COG0702@1|root,COG0702@2|Bacteria,1MW54@1224|Proteobacteria,1RY2H@1236|Gammaproteobacteria,1WX0H@135613|Chromatiales 135613|Chromatiales GM epimerase dehydratase - - 1.6.5.3,1.6.99.3 ko:K00329,ko:K00356 ko00190,map00190 - R11945 RC00061 ko00000,ko00001,ko01000 - - - NAD_binding_10 k59_781374_2 653045.Strvi_4203 8.71e-05 48.9 COG1028@1|root,COG1028@2|Bacteria,2H8Y7@201174|Actinobacteria 201174|Actinobacteria IQ Short-chain dehydrogenase reductase sdr - - - - - - - - - - - - adh_short_C2 k59_1291083_1 1380393.JHVP01000007_gene4301 1.24e-46 167.0 COG0312@1|root,COG0312@2|Bacteria,2GJ4E@201174|Actinobacteria,4ERBS@85013|Frankiales 201174|Actinobacteria S peptidase U62, modulator of DNA gyrase - - - ko:K03568 - - - - ko00000,ko01002 - - - PmbA_TldD k59_670028_1 391625.PPSIR1_24834 9.55e-31 126.0 2DV3U@1|root,33TXD@2|Bacteria,1NUW0@1224|Proteobacteria,439EF@68525|delta/epsilon subdivisions,2X4PK@28221|Deltaproteobacteria,2Z06V@29|Myxococcales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_1460742_1 1122216.AUHW01000022_gene1074 7.77e-07 48.5 COG1925@1|root,COG1925@2|Bacteria,1VNNY@1239|Firmicutes 1239|Firmicutes G PTS HPr component phosphorylation site ptsH - - ko:K11189 - - - - ko00000,ko02000 4.A.2.1 - - PTS-HPr k59_1460742_2 1122603.ATVI01000006_gene202 1.79e-53 191.0 COG1080@1|root,COG1080@2|Bacteria,1MUT8@1224|Proteobacteria,1RN6R@1236|Gammaproteobacteria,1X33X@135614|Xanthomonadales 135614|Xanthomonadales G General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) ptsI - 2.7.3.9 ko:K08483 ko02060,map02060 - - - ko00000,ko00001,ko01000,ko02000 8.A.7 - - PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C k59_840923_1 426114.THI_1680 1.14e-05 48.1 COG1960@1|root,COG1960@2|Bacteria,1MU20@1224|Proteobacteria,2VGZD@28216|Betaproteobacteria,1KITG@119065|unclassified Burkholderiales 28216|Betaproteobacteria C acyl-CoA dehydrogenase - - - ko:K20035 ko00920,map00920 - R11130 RC03363 ko00000,ko00001,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_C,Acyl-CoA_dh_M,Acyl-CoA_dh_N,AcylCoA_DH_N k59_278196_1 985054.JQEZ01000006_gene134 7.77e-82 256.0 COG0019@1|root,COG0019@2|Bacteria,1MUA6@1224|Proteobacteria,2TQPB@28211|Alphaproteobacteria,4NA9J@97050|Ruegeria 28211|Alphaproteobacteria E Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine lysA GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008836,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016829,GO:0016830,GO:0016831,GO:0019752,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046451,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.1.1.20 ko:K01586 ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R00451 RC00299 ko00000,ko00001,ko00002,ko01000 - - - Orn_Arg_deC_N,Orn_DAP_Arg_deC k59_1579716_1 436308.Nmar_1091 1.14e-131 384.0 COG1378@1|root,arCOG02037@2157|Archaea,41T17@651137|Thaumarchaeota 651137|Thaumarchaeota K Sugar-specific transcriptional regulator TrmB - - - - - - - - - - - - TrmB k59_1409841_1 1094508.Tsac_0966 1.72e-23 99.0 COG0209@1|root,COG1372@1|root,COG0209@2|Bacteria,COG1372@2|Bacteria,1TPFH@1239|Firmicutes,249EN@186801|Clostridia,42F6G@68295|Thermoanaerobacterales 186801|Clostridia F Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen nrdJ - 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - Intein_splicing,LAGLIDADG_3,Ribonuc_red_2_N,Ribonuc_red_lgC,Ribonuc_red_lgN,TSCPD k59_1409841_2 1304880.JAGB01000001_gene974 1.08e-31 125.0 COG0209@1|root,COG1372@1|root,COG0209@2|Bacteria,COG1372@2|Bacteria,1TPFH@1239|Firmicutes,249EN@186801|Clostridia 186801|Clostridia F Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen nrdJ - 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - Intein_splicing,LAGLIDADG_3,Ribonuc_red_2_N,Ribonuc_red_lgC,Ribonuc_red_lgN,TSCPD k59_1409844_1 436308.Nmar_0888 3.02e-93 285.0 COG1199@1|root,arCOG00770@2157|Archaea,41T2V@651137|Thaumarchaeota 651137|Thaumarchaeota K HELICc2 - - - - - - - - - - - - Helicase_C_2 k59_499110_1 876044.IMCC3088_2220 3.94e-76 244.0 COG1292@1|root,COG1292@2|Bacteria,1MV0K@1224|Proteobacteria,1RP3E@1236|Gammaproteobacteria,1J5HD@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria U Belongs to the BCCT transporter (TC 2.A.15) family - - - ko:K03451 - - - - ko00000 2.A.15 - - BCCT k59_1409850_1 247633.GP2143_13911 9.06e-20 87.4 COG2267@1|root,COG2267@2|Bacteria,1MUFB@1224|Proteobacteria,1S22A@1236|Gammaproteobacteria,1J9YM@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria I Alpha/beta hydrolase family - - - - - - - - - - - - Abhydrolase_1,Hydrolase_4 k59_1409850_2 1415778.JQMM01000001_gene1572 1.09e-29 109.0 COG3339@1|root,COG3339@2|Bacteria,1MZR5@1224|Proteobacteria,1S912@1236|Gammaproteobacteria,1J6X5@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Protein of unknown function (DUF1232) - - - - - - - - - - - - DUF1232 k59_1180492_1 511.JT27_12185 8.91e-42 147.0 COG3384@1|root,COG3384@2|Bacteria,1MW77@1224|Proteobacteria,2VTUV@28216|Betaproteobacteria,3T4UJ@506|Alcaligenaceae 28216|Betaproteobacteria S Catalytic LigB subunit of aromatic ring-opening dioxygenase - - 1.13.11.16,1.13.11.8 ko:K04101,ko:K05713 ko00360,ko00362,ko00624,ko00627,ko01120,ko01220,map00360,map00362,map00624,map00627,map01120,map01220 M00545 R01632,R03550,R04280,R04376,R06788,R09565 RC00233,RC00387,RC00535,RC01140,RC01364,RC02567,RC02694 br01602,ko00000,ko00001,ko00002,ko01000 - - - LigB k59_1522135_1 377629.TERTU_2601 8.92e-25 107.0 COG0665@1|root,COG4121@1|root,COG0665@2|Bacteria,COG4121@2|Bacteria,1MZW5@1224|Proteobacteria,1RMTE@1236|Gammaproteobacteria,2PMJ9@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria E S-adenosyl-L-methionine-dependent methyltransferase mnmC GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0003824,GO:0004808,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016491,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0055114,GO:0071704,GO:0071949,GO:0090304,GO:0097159,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363 2.1.1.61 ko:K15461 - - R00601,R08702 RC00003,RC00053,RC00060,RC01483 ko00000,ko01000,ko03016 - - - DAO,Methyltransf_30 k59_1347227_1 314285.KT71_14264 2.05e-62 209.0 COG0612@1|root,COG0612@2|Bacteria,1MVST@1224|Proteobacteria,1SMZF@1236|Gammaproteobacteria,1J7PF@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Insulinase (Peptidase family M16) - - - - - - - - - - - - Peptidase_M16,Peptidase_M16_C k59_392946_1 199310.c5283 3.22e-52 165.0 COG3414@1|root,COG3414@2|Bacteria,1RET1@1224|Proteobacteria,1S47F@1236|Gammaproteobacteria,3XPPQ@561|Escherichia 1236|Gammaproteobacteria G The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II UlaABC PTS system is involved in ascorbate transport ulaB GO:0003674,GO:0003824,GO:0005215,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008643,GO:0009401,GO:0015144,GO:0015711,GO:0015749,GO:0015849,GO:0015882,GO:0016740,GO:0016772,GO:0016773,GO:0022804,GO:0022857,GO:0034219,GO:0034220,GO:0035461,GO:0046942,GO:0051179,GO:0051180,GO:0051181,GO:0051182,GO:0051234,GO:0055085,GO:0071702,GO:0090563,GO:0090585,GO:0098656,GO:1903825,GO:1905039 2.7.1.194 ko:K02822 ko00053,ko01100,ko01120,ko02060,map00053,map01100,map01120,map02060 M00283,M00550 R07671 RC00017,RC03206 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.7.1 - iSDY_1059.SDY_4363 PTS_IIB k59_392946_2 220341.16505508 2.24e-51 174.0 COG3037@1|root,COG3037@2|Bacteria,1MWNR@1224|Proteobacteria,1RP9S@1236|Gammaproteobacteria,3ZJH9@590|Salmonella 1236|Gammaproteobacteria U PTS system sugar-specific permease component ulaA GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008643,GO:0009401,GO:0015144,GO:0015711,GO:0015749,GO:0015849,GO:0015882,GO:0016020,GO:0016740,GO:0016772,GO:0016773,GO:0022804,GO:0022857,GO:0034219,GO:0034220,GO:0035461,GO:0042802,GO:0044464,GO:0046942,GO:0051179,GO:0051180,GO:0051181,GO:0051182,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0090563,GO:0090585,GO:0098656,GO:1903825,GO:1905039 2.7.1.194 ko:K02822,ko:K03475 ko00053,ko01100,ko01120,ko02060,map00053,map01100,map01120,map02060 M00283,M00550 R07671 RC00017,RC03206 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.7.1 - iB21_1397.B21_04022,iEC55989_1330.EC55989_4750,iECBD_1354.ECBD_3841,iECB_1328.ECB_04060,iECD_1391.ECD_04060,iECIAI1_1343.ECIAI1_4426,iECO111_1330.ECO111_5021,iETEC_1333.ETEC_4539,iEcSMS35_1347.EcSMS35_4664 EIIC-GAT,PTS_IIB k59_1633640_1 1163617.SCD_n02699 4.75e-18 87.8 COG4942@1|root,COG4942@2|Bacteria,1MY3E@1224|Proteobacteria,2VIV9@28216|Betaproteobacteria 28216|Betaproteobacteria D peptidase envC - - - - - - - - - - - Peptidase_M23 k59_732385_1 768671.ThimaDRAFT_1207 1.47e-31 124.0 COG2918@1|root,COG2918@2|Bacteria,1MW9B@1224|Proteobacteria,1RPNQ@1236|Gammaproteobacteria,1WWFZ@135613|Chromatiales 135613|Chromatiales H Belongs to the glutamate--cysteine ligase type 1 family. Type 1 subfamily gshA - 6.3.2.2 ko:K01919 ko00270,ko00480,ko01100,map00270,map00480,map01100 M00118 R00894,R10993 RC00064,RC00090 ko00000,ko00001,ko00002,ko01000 - - - Glu_cys_ligase k59_953168_1 698761.RTCIAT899_CH10720 1.33e-24 105.0 COG0685@1|root,COG0685@2|Bacteria,1MXTZ@1224|Proteobacteria,2TWKE@28211|Alphaproteobacteria,4BCGP@82115|Rhizobiaceae 28211|Alphaproteobacteria E Methylenetetrahydrofolate reductase - - - - - - - - - - - - MTHFR k59_619272_1 1121875.KB907549_gene2020 8.08e-62 197.0 COG0518@1|root,COG0518@2|Bacteria,4NYBA@976|Bacteroidetes,1I8HB@117743|Flavobacteriia 976|Bacteroidetes F Glutamine amidotransferase class-I - - 6.3.5.2 ko:K01951 ko00230,ko00983,ko01100,map00230,map00983,map01100 M00050 R01230,R01231,R08244 RC00010,RC00204 ko00000,ko00001,ko00002,ko01000,ko01002 - - - GATase k59_782632_1 1123368.AUIS01000026_gene1464 7.5e-117 359.0 COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,1RN3H@1236|Gammaproteobacteria,2NBVQ@225057|Acidithiobacillales 225057|Acidithiobacillales KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance - - 2.7.6.5,3.1.7.2 ko:K00951,ko:K01139 ko00230,map00230 - R00336,R00429 RC00002,RC00078 ko00000,ko00001,ko01000,ko03009 - - - ACT_4,HD_4,RelA_SpoT,TGS k59_1688894_1 765913.ThidrDRAFT_4513 0.000176 49.7 COG0457@1|root,COG1672@1|root,COG0457@2|Bacteria,COG1672@2|Bacteria,1R3SH@1224|Proteobacteria,1S6CN@1236|Gammaproteobacteria,1WZCC@135613|Chromatiales 135613|Chromatiales S PFAM Archaeal ATPase - - - - - - - - - - - - - k59_1237467_1 861299.J421_2500 1.14e-11 69.7 COG0642@1|root,COG0642@2|Bacteria,1ZTZE@142182|Gemmatimonadetes 142182|Gemmatimonadetes T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA k59_1008530_1 1197477.IA57_06200 6.28e-91 283.0 COG0449@1|root,COG0449@2|Bacteria,4NE8Q@976|Bacteroidetes,1HX0U@117743|Flavobacteriia 976|Bacteroidetes M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source glmS - 2.6.1.16 ko:K00820 ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931 - R00768 RC00010,RC00163,RC02752 ko00000,ko00001,ko01000,ko01002 - - - GATase_6,SIS k59_1798221_1 1248760.ANFZ01000005_gene2236 1.67e-125 367.0 COG2201@1|root,COG2201@2|Bacteria,1MWCN@1224|Proteobacteria,2TSGV@28211|Alphaproteobacteria,2K085@204457|Sphingomonadales 204457|Sphingomonadales NT catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR - - 3.1.1.61,3.5.1.44 ko:K03412 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko02022,ko02035 - - - CheB_methylest,Response_reg k59_221316_1 702113.PP1Y_AT11618 1.9e-69 225.0 COG0477@1|root,COG2814@2|Bacteria,1MUDA@1224|Proteobacteria,2TS0P@28211|Alphaproteobacteria 28211|Alphaproteobacteria EGP Major facilitator superfamily hsrA GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944 - - - - - - - - - - MFS_1,TRI12 k59_842174_1 1216007.AOPM01000096_gene464 1.66e-58 196.0 COG0664@1|root,COG0664@2|Bacteria,1QU34@1224|Proteobacteria,1T2BY@1236|Gammaproteobacteria,2Q0SS@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria T COG1226 Kef-type K transport systems - - - ko:K10716 - - - - ko00000,ko02000 1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6 - - Ion_trans k59_1688915_1 926569.ANT_22310 9.1e-19 83.6 COG0816@1|root,COG0816@2|Bacteria,2G74F@200795|Chloroflexi 200795|Chloroflexi J Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA - GO:0000966,GO:0000967,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0022613,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360 - ko:K07447 - - - - ko00000,ko01000 - - - RuvX k59_671172_1 1137281.D778_01913 3.77e-39 144.0 COG0739@1|root,COG0739@2|Bacteria,4NIH1@976|Bacteroidetes,1HZT8@117743|Flavobacteriia 976|Bacteroidetes M Peptidase family M23 - - - - - - - - - - - - Peptidase_M23 k59_1745902_1 1229909.NSED_05805 3.41e-74 244.0 COG0168@1|root,COG0517@1|root,arCOG00606@2157|Archaea,arCOG04145@2157|Archaea,41SZ8@651137|Thaumarchaeota 651137|Thaumarchaeota P CBS domain - - - ko:K03498 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - - CBS,TrkH k59_279389_1 1122613.ATUP01000001_gene866 2.23e-17 84.3 COG4206@1|root,COG4206@2|Bacteria,1QUPS@1224|Proteobacteria,2TW3S@28211|Alphaproteobacteria,43WM0@69657|Hyphomonadaceae 28211|Alphaproteobacteria H TonB dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_1292297_1 1215092.PA6_003_01710 4.75e-121 357.0 COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,1RNB5@1236|Gammaproteobacteria,1YD22@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria C CoA-transferase family III coaT - - - - - - - - - - - CoA_transf_3 k59_842195_3 1122137.AQXF01000001_gene2776 8.4e-96 283.0 2BZV0@1|root,2Z7UQ@2|Bacteria,1QEAD@1224|Proteobacteria,2UQ8G@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_782692_1 1122137.AQXF01000001_gene3222 2.34e-37 136.0 COG1409@1|root,COG1409@2|Bacteria,1MV0H@1224|Proteobacteria,2TZMG@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes - - - - - - - - - - - - - k59_221353_1 511145.b3474 1.05e-125 365.0 COG0628@1|root,COG0628@2|Bacteria,1MXXU@1224|Proteobacteria,1RQCM@1236|Gammaproteobacteria,3XP7B@561|Escherichia 1236|Gammaproteobacteria S transporter activity yhhT GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0009372,GO:0009987,GO:0015562,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0044764,GO:0051179,GO:0051234,GO:0051704,GO:0055085,GO:0071944 - ko:K11744 - - - - ko00000 - - - AI-2E_transport k59_109830_1 314285.KT71_17281 1.9e-88 281.0 COG2905@1|root,COG2905@2|Bacteria,1MW8U@1224|Proteobacteria,1RPSJ@1236|Gammaproteobacteria,1J4Z1@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T containing cAMP-binding and CBS domains - - - ko:K07182 - - - - ko00000 - - - CBS,DUF294,DUF294_C,cNMP_binding k59_1070026_1 702113.PP1Y_AT30816 3.35e-109 340.0 COG0013@1|root,COG0013@2|Bacteria,1MU9A@1224|Proteobacteria,2TQV4@28211|Alphaproteobacteria,2K28K@204457|Sphingomonadales 204457|Sphingomonadales J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain alaS - 6.1.1.7 ko:K01872 ko00970,map00970 M00359,M00360 R03038 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DHHA1,tRNA-synt_2c,tRNA_SAD k59_1640004_1 279010.BL01232 1.17e-88 288.0 COG5297@1|root,COG5297@2|Bacteria,1V1T2@1239|Firmicutes,4HUDU@91061|Bacilli,1ZE8U@1386|Bacillus 91061|Bacilli G Cellulose binding domain - - 3.2.1.4 ko:K01179 ko00500,ko01100,map00500,map01100 - R06200,R11307,R11308 - ko00000,ko00001,ko01000 - GH5,GH9 - CBM_3,Glyco_hydro_9 k59_1752942_1 983544.Lacal_2000 1.08e-103 308.0 COG0741@1|root,COG0741@2|Bacteria,4NH4W@976|Bacteroidetes,1HXX8@117743|Flavobacteriia 976|Bacteroidetes M Murein transglycosylase mltD_2 - - - - - - - - - - - SLT k59_1074888_1 1278307.KB907028_gene421 0.00037 43.9 COG0287@1|root,COG1605@1|root,COG0287@2|Bacteria,COG1605@2|Bacteria,1MVUT@1224|Proteobacteria,1RQB3@1236|Gammaproteobacteria,2QH7E@267894|Psychromonadaceae 1236|Gammaproteobacteria E Chorismate mutase type II tyrA GO:0000166,GO:0003674,GO:0003824,GO:0004106,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006558,GO:0006570,GO:0006571,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008977,GO:0009058,GO:0009072,GO:0009073,GO:0009094,GO:0009095,GO:0009987,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0016853,GO:0016866,GO:0017144,GO:0019438,GO:0019752,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0070403,GO:0071704,GO:0097159,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902221,GO:1902223 1.3.1.12,5.4.99.5 ko:K04517,ko:K14187 ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230 M00024,M00025 R01715,R01728 RC00125,RC03116 ko00000,ko00001,ko00002,ko01000 - - iECUMN_1333.ECUMN_2925 ACT,CM_2,PDH k59_1074888_2 1234364.AMSF01000088_gene2730 1.65e-87 266.0 COG1062@1|root,COG1062@2|Bacteria,1MUK4@1224|Proteobacteria,1RNQ4@1236|Gammaproteobacteria,1X3UT@135614|Xanthomonadales 135614|Xanthomonadales C Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily adhC - 1.1.1.1,1.1.1.284 ko:K00121 ko00010,ko00071,ko00350,ko00625,ko00626,ko00680,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,ko05204,map00010,map00071,map00350,map00625,map00626,map00680,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01200,map01220,map05204 - R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R06983,R07105,R08281,R08306,R08310 RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01715,RC01734,RC02273 ko00000,ko00001,ko01000 - - - ADH_N,ADH_zinc_N k59_962127_1 1282361.ABAC402_15825 5.24e-60 207.0 COG3451@1|root,COG3451@2|Bacteria,1MXH0@1224|Proteobacteria,2TR1U@28211|Alphaproteobacteria,2KEYI@204458|Caulobacterales 204458|Caulobacterales U Type VI secretion protein - - - ko:K03199 ko03070,map03070 M00333 - - ko00000,ko00001,ko00002,ko02044 3.A.7 - - CagE_TrbE_VirB k59_962127_2 715226.ABI_22770 4.58e-38 128.0 COG3702@1|root,COG3702@2|Bacteria,1N1YI@1224|Proteobacteria,2UDDW@28211|Alphaproteobacteria,2KHE9@204458|Caulobacterales 204458|Caulobacterales U Type IV secretory pathway, VirB3-like protein - - - ko:K03198 ko03070,map03070 M00333 - - ko00000,ko00001,ko00002,ko02044 3.A.7 - - VirB3 k59_1188079_1 158500.BV97_01076 1.17e-46 153.0 2AFJI@1|root,315KD@2|Bacteria,1NDXS@1224|Proteobacteria,2UHQK@28211|Alphaproteobacteria,2K7NU@204457|Sphingomonadales 204457|Sphingomonadales - - - - - - - - - - - - - - OMP_b-brl k59_1752956_1 1082933.MEA186_22656 3.05e-50 175.0 COG3653@1|root,COG3653@2|Bacteria,1MWWY@1224|Proteobacteria,2TSZZ@28211|Alphaproteobacteria 28211|Alphaproteobacteria Q COG3653 N-acyl-D-aspartate D-glutamate deacylase dan - 3.5.1.81 ko:K06015 - - R02192 RC00064,RC00328 ko00000,ko01000 - - - Amidohydro_3 k59_171434_1 279238.Saro_2542 3.06e-76 244.0 COG1217@1|root,COG1217@2|Bacteria,1MV5Q@1224|Proteobacteria,2TR63@28211|Alphaproteobacteria,2K169@204457|Sphingomonadales 204457|Sphingomonadales T GTP-binding protein TypA typA - - ko:K06207 - - - - ko00000 - - - EFG_C,GTP_EFTU,GTP_EFTU_D2 k59_510131_1 1229909.NSED_00845 5.93e-96 288.0 COG0681@1|root,arCOG01739@2157|Archaea,41SQ2@651137|Thaumarchaeota 651137|Thaumarchaeota U Signal peptidase - - 3.4.21.89 ko:K13280 ko03060,map03060 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_S24 k59_510131_2 436308.Nmar_0209 8.67e-43 147.0 arCOG08023@1|root,arCOG08023@2157|Archaea,41SKK@651137|Thaumarchaeota 651137|Thaumarchaeota S Zinc finger domain - - - - - - - - - - - - zinc_ribbon_2 k59_1357632_1 1149133.ppKF707_2621 5.47e-131 389.0 COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,1RMQ4@1236|Gammaproteobacteria,1YJDT@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria IQ AMP-binding enzyme C-terminal domain - - 6.2.1.41 ko:K18687 ko00984,ko01100,ko01120,map00984,map01100,map01120 - R10769 RC00004,RC00014 ko00000,ko00001,ko01000 - - - AMP-binding,AMP-binding_C k59_1357632_2 13689.BV96_00187 2.49e-106 315.0 COG1028@1|root,COG1028@2|Bacteria,1R766@1224|Proteobacteria,2UNRG@28211|Alphaproteobacteria,2K2DA@204457|Sphingomonadales 204457|Sphingomonadales IQ KR domain - - - - - - - - - - - - adh_short_C2 k59_792812_1 622637.KE124774_gene3016 1.44e-25 100.0 COG0225@1|root,COG0225@2|Bacteria,1MVUS@1224|Proteobacteria,2TSAM@28211|Alphaproteobacteria,36Y2B@31993|Methylocystaceae 28211|Alphaproteobacteria O Peptide methionine sulfoxide reductase msrA - 1.8.4.11 ko:K07304 - - - - ko00000,ko01000 - - - PMSR k59_792815_1 1229909.NSED_09115 2.85e-96 293.0 COG1361@1|root,arCOG02080@2157|Archaea,41T6N@651137|Thaumarchaeota 651137|Thaumarchaeota M extracellular matrix structural constituent - - - - - - - - - - - - - k59_792815_2 436308.Nmar_1713 3.52e-22 91.3 COG1136@1|root,arCOG00922@2157|Archaea,41T2R@651137|Thaumarchaeota 651137|Thaumarchaeota E ABC-type antimicrobial peptide transport system, ATPase component - - - ko:K02003,ko:K09810 ko02010,map02010 M00255,M00258 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1,3.A.1.125 - - ABC_tran k59_1470693_2 1159870.KB907784_gene686 1.24e-62 195.0 COG0494@1|root,COG0494@2|Bacteria,1RDGJ@1224|Proteobacteria,2VIDX@28216|Betaproteobacteria,3T23J@506|Alcaligenaceae 28216|Betaproteobacteria L Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage nudH - - ko:K08311 ko03018,map03018 - R10816 RC00002 ko00000,ko00001,ko01000,ko03019 - - - NUDIX k59_171454_1 519989.ECTPHS_01999 6.8e-114 345.0 COG0171@1|root,COG0388@1|root,COG0171@2|Bacteria,COG0388@2|Bacteria,1MU9U@1224|Proteobacteria,1RNKA@1236|Gammaproteobacteria,1WWS1@135613|Chromatiales 135613|Chromatiales H Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source nadE - 6.3.5.1 ko:K01950 ko00760,ko01100,map00760,map01100 M00115 R00257 RC00010,RC00100 ko00000,ko00001,ko00002,ko01000 - - - CN_hydrolase,NAD_synthase k59_1708_1 1069080.KB913028_gene520 1.24e-09 59.7 COG2050@1|root,COG2050@2|Bacteria 2|Bacteria Q thiolester hydrolase activity - - 2.5.1.129 ko:K03186 ko00130,ko00627,ko00940,ko01100,ko01110,ko01120,ko01220,map00130,map00627,map00940,map01100,map01110,map01120,map01220 M00117 R01238,R02952,R03367,R04985,R04986,R11225 RC00391,RC00814,RC03392 ko00000,ko00001,ko00002,ko01000 - - - 4HBT k59_397308_1 1229909.NSED_05135 1.65e-110 334.0 COG0504@1|root,arCOG00063@2157|Archaea,41S7G@651137|Thaumarchaeota 651137|Thaumarchaeota F Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates pyrG - 6.3.4.2 ko:K01937 ko00240,ko01100,map00240,map01100 M00052 R00571,R00573 RC00010,RC00074 ko00000,ko00001,ko00002,ko01000 - - - CTP_synth_N,GATase k59_397308_2 1229909.NSED_05145 1.12e-12 66.6 COG0061@1|root,COG0640@1|root,arCOG00394@2157|Archaea,arCOG01348@2157|Archaea,41SEC@651137|Thaumarchaeota 651137|Thaumarchaeota HK Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP - - 2.7.1.23 ko:K00858 ko00760,ko01100,map00760,map01100 - R00104 RC00002,RC00078 ko00000,ko00001,ko01000 - - - NAD_kinase k59_1414088_1 1168059.KB899087_gene4381 1.92e-113 348.0 COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2TQR1@28211|Alphaproteobacteria,3EYAA@335928|Xanthobacteraceae 28211|Alphaproteobacteria C Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the reversible oxidation of betaine aldehyde to the corresponding acid betB - 1.2.1.8 ko:K00130 ko00260,ko01100,map00260,map01100 M00555 R02565,R02566 RC00080 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_1018947_1 436308.Nmar_0587 3.19e-39 133.0 COG0347@1|root,arCOG02305@2157|Archaea 2157|Archaea K Belongs to the P(II) protein family - - - ko:K04751 ko02020,map02020 - - - ko00000,ko00001 - - - DUF2226,P-II k59_1018947_2 1229909.NSED_09450 3.46e-66 208.0 COG0347@1|root,arCOG02305@2157|Archaea 2157|Archaea K Belongs to the P(II) protein family - - - ko:K04751 ko02020,map02020 - - - ko00000,ko00001 - - - P-II k59_1357668_1 686340.Metal_1551 1.6e-59 200.0 COG1570@1|root,COG1570@2|Bacteria,1MUA4@1224|Proteobacteria,1RNAZ@1236|Gammaproteobacteria,1XE33@135618|Methylococcales 135618|Methylococcales L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides xseA - 3.1.11.6 ko:K03601 ko03430,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - Exonuc_VII_L,tRNA_anti_2 k59_284517_1 314285.KT71_16746 1.43e-105 318.0 COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,1RMBQ@1236|Gammaproteobacteria,1J4DZ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Belongs to the aldehyde dehydrogenase family gabD - 1.2.1.16,1.2.1.20,1.2.1.79 ko:K00135 ko00250,ko00310,ko00350,ko00650,ko00760,ko01100,ko01120,map00250,map00310,map00350,map00650,map00760,map01100,map01120 M00027 R00713,R00714,R02401 RC00080 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_1131625_1 439235.Dalk_0906 1.09e-64 217.0 COG4623@1|root,COG4623@2|Bacteria,1MWDS@1224|Proteobacteria,42NCG@68525|delta/epsilon subdivisions,2WK7N@28221|Deltaproteobacteria,2MIZV@213118|Desulfobacterales 28221|Deltaproteobacteria M Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella - - - ko:K18691 - - - - ko00000,ko01000,ko01011 - - - SBP_bac_3,SLT k59_340884_3 880073.Calab_1470 9.73e-63 201.0 COG0270@1|root,COG0270@2|Bacteria 2|Bacteria L DNA (cytosine-5-)-methyltransferase activity dcm - 2.1.1.37 ko:K00558 ko00270,ko01100,ko05206,map00270,map01100,map05206 M00035 R04858 RC00003,RC00332 ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036 - - - DNA_methylase k59_171512_1 391624.OIHEL45_04890 2.51e-22 98.6 COG0329@1|root,COG0329@2|Bacteria,1MUCM@1224|Proteobacteria,2TR5W@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) dapA - 4.3.3.7 ko:K01714 ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R10147 RC03062,RC03063 ko00000,ko00001,ko00002,ko01000 - - - DHDPS k59_1301347_1 436308.Nmar_1627 1.87e-81 264.0 COG0209@1|root,arCOG03713@1|root,arCOG03713@2157|Archaea,arCOG04276@2157|Archaea,41SAH@651137|Thaumarchaeota 651137|Thaumarchaeota F Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen - - 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - ATP-cone,Ribonuc_red_lgC,Ribonuc_red_lgN k59_905509_1 436308.Nmar_1388 3.11e-149 434.0 COG1032@1|root,arCOG01357@2157|Archaea,41SCX@651137|Thaumarchaeota 651137|Thaumarchaeota C Radical SAM - - - - - - - - - - - - Radical_SAM k59_171517_1 408672.NBCG_00750 2.03e-48 170.0 COG1236@1|root,COG1236@2|Bacteria,2HEXB@201174|Actinobacteria,4DQ4R@85009|Propionibacteriales 201174|Actinobacteria J Beta-Casp domain - - - ko:K07576 - - - - ko00000 - - - Beta-Casp,Lactamase_B,Lactamase_B_2,RMMBL k59_736375_1 316407.85676591 4.26e-52 171.0 COG1175@1|root,COG1175@2|Bacteria,1MVAP@1224|Proteobacteria,1RNQF@1236|Gammaproteobacteria,3XM4S@561|Escherichia 1236|Gammaproteobacteria G probably responsible for the translocation of the substrate across the membrane ugpA GO:0001406,GO:0001407,GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008509,GO:0008514,GO:0015075,GO:0015169,GO:0015605,GO:0015711,GO:0015748,GO:0015794,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0032991,GO:0034220,GO:0043190,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055052,GO:0055085,GO:0071702,GO:0071944,GO:0098533,GO:0098656,GO:0098796,GO:0098797,GO:1901264,GO:1901505,GO:1902494,GO:1902495,GO:1904949,GO:1990351 - ko:K05814 ko02010,map02010 M00198 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.3 - iSFxv_1172.SFxv_3786 BPD_transp_1 k59_736375_2 316407.85676592 1.48e-51 169.0 COG0395@1|root,COG0395@2|Bacteria,1MUWS@1224|Proteobacteria,1RMKG@1236|Gammaproteobacteria,3XNKK@561|Escherichia 1236|Gammaproteobacteria G probably responsible for the translocation of the substrate across the membrane ugpE GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008509,GO:0008514,GO:0015075,GO:0015169,GO:0015605,GO:0015711,GO:0015748,GO:0015794,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0032991,GO:0034220,GO:0043190,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055052,GO:0055085,GO:0071702,GO:0071944,GO:0098533,GO:0098656,GO:0098796,GO:0098797,GO:1901264,GO:1901505,GO:1902494,GO:1902495,GO:1904949,GO:1990351 - ko:K05815 ko02010,map02010 M00198 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.3 - iLF82_1304.LF82_2362,iNRG857_1313.NRG857_17110,iYL1228.KPN_03811 BPD_transp_1 k59_566944_1 1379270.AUXF01000003_gene3822 2.7e-74 249.0 COG0243@1|root,COG0437@1|root,COG0243@2|Bacteria,COG0437@2|Bacteria,1ZSRY@142182|Gemmatimonadetes 142182|Gemmatimonadetes C 4Fe-4S dicluster domain - - - ko:K00184 - - - - ko00000 5.A.3 - - Fer4_7,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,TAT_signal k59_1743_1 589873.EP13_15060 2.13e-92 285.0 COG2211@1|root,COG2211@2|Bacteria,1MVUM@1224|Proteobacteria,1RP5J@1236|Gammaproteobacteria,464K4@72275|Alteromonadaceae 1236|Gammaproteobacteria G COG2211 Na melibiose symporter and related transporters - - - ko:K03292,ko:K16210 - - - - ko00000,ko02000 2.A.2,2.A.2.5 - - MFS_2 k59_1583520_1 797209.ZOD2009_14171 0.000153 43.5 COG4948@1|root,arCOG01168@2157|Archaea,2XUBS@28890|Euryarchaeota,23UR5@183963|Halobacteria 183963|Halobacteria M COG4948 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily - - - - - - - - - - - - MR_MLE_C,MR_MLE_N k59_624052_1 347834.RHE_CH01631 3.55e-07 52.8 COG0647@1|root,COG0647@2|Bacteria,1RFSZ@1224|Proteobacteria,2U7SF@28211|Alphaproteobacteria,4B7RB@82115|Rhizobiaceae 28211|Alphaproteobacteria G UMP catabolic process - - - - - - - - - - - - - k59_624052_3 1122137.AQXF01000006_gene911 4.43e-82 243.0 COG0745@1|root,COG0745@2|Bacteria,1RD7E@1224|Proteobacteria,2U745@28211|Alphaproteobacteria 28211|Alphaproteobacteria T Response regulator receiver divK - - ko:K11443 ko02020,ko04112,map02020,map04112 M00511 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg k59_624052_4 1122137.AQXF01000006_gene910 8.54e-13 67.0 COG0745@1|root,COG2199@1|root,COG0745@2|Bacteria,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria,2TQQM@28211|Alphaproteobacteria 28211|Alphaproteobacteria T response regulator containing a CheY-like receiver domain and a GGDEF domain pleD GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0042802,GO:0044424,GO:0044464 2.7.7.65 ko:K02488 ko02020,ko04112,map02020,map04112 M00511 R08057 - ko00000,ko00001,ko00002,ko01000,ko02022 - - - GGDEF,Response_reg k59_228491_1 1286631.X805_21830 9.83e-44 149.0 COG0424@1|root,COG0424@2|Bacteria,1RDA9@1224|Proteobacteria,2VQUQ@28216|Betaproteobacteria,1KKN2@119065|unclassified Burkholderiales 28216|Betaproteobacteria D Maf-like protein yceF - - ko:K06287 - - - - ko00000 - - - Maf k59_341820_1 1122137.AQXF01000002_gene436 4.05e-110 326.0 COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,2TREJ@28211|Alphaproteobacteria 28211|Alphaproteobacteria I Catalyzes the formation of 3-methylbut-2-enoyl CoA from 3-methylbutanoyl CoA ivd - 1.3.8.4 ko:K00253 ko00280,ko01100,map00280,map01100 M00036 R04095 RC00246 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_341820_2 1122137.AQXF01000002_gene435 0.000657 41.6 COG4770@1|root,COG4770@2|Bacteria,1P6RE@1224|Proteobacteria,2TRC2@28211|Alphaproteobacteria 28211|Alphaproteobacteria I Acetyl propionyl-CoA carboxylase alpha subunit mccA - 6.4.1.3,6.4.1.4 ko:K01965,ko:K01968 ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200 M00036,M00373,M00741 R01859,R04138 RC00097,RC00367,RC00609,RC00942 ko00000,ko00001,ko00002,ko01000 - - - Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2 k59_1245672_1 511145.b3450 3.83e-117 342.0 COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,1RM9E@1236|Gammaproteobacteria,3XPDF@561|Escherichia 1236|Gammaproteobacteria P Part of the ABC transporter complex UgpABCE involved in sn-glycerol-3-phosphate import. Responsible for energy coupling to the transport system ugpC GO:0000166,GO:0001406,GO:0001407,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006820,GO:0008144,GO:0008150,GO:0008509,GO:0008514,GO:0015075,GO:0015169,GO:0015399,GO:0015405,GO:0015430,GO:0015605,GO:0015711,GO:0015748,GO:0015794,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0030554,GO:0031224,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0034220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0043167,GO:0043168,GO:0043190,GO:0043492,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055052,GO:0055085,GO:0071702,GO:0071944,GO:0097159,GO:0097367,GO:0098533,GO:0098656,GO:0098796,GO:0098797,GO:1901264,GO:1901265,GO:1901363,GO:1901505,GO:1902494,GO:1902495,GO:1904949,GO:1990351 3.6.3.20 ko:K05816 ko02010,map02010 M00198 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.1.3 - iAF1260.b3450,iB21_1397.B21_03252,iBWG_1329.BWG_3141,iECABU_c1320.ECABU_c38800,iECB_1328.ECB_03299,iECDH10B_1368.ECDH10B_3624,iECD_1391.ECD_03299,iETEC_1333.ETEC_3696,iJO1366.b3450,iJR904.b3450,iUMNK88_1353.UMNK88_4218,iY75_1357.Y75_RS19980,ic_1306.c4239 ABC_tran,TOBE_2 k59_1245672_2 316407.85676592 4.18e-49 163.0 COG0395@1|root,COG0395@2|Bacteria,1MUWS@1224|Proteobacteria,1RMKG@1236|Gammaproteobacteria,3XNKK@561|Escherichia 1236|Gammaproteobacteria G probably responsible for the translocation of the substrate across the membrane ugpE GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008509,GO:0008514,GO:0015075,GO:0015169,GO:0015605,GO:0015711,GO:0015748,GO:0015794,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0032991,GO:0034220,GO:0043190,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055052,GO:0055085,GO:0071702,GO:0071944,GO:0098533,GO:0098656,GO:0098796,GO:0098797,GO:1901264,GO:1901505,GO:1902494,GO:1902495,GO:1904949,GO:1990351 - ko:K05815 ko02010,map02010 M00198 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.3 - iLF82_1304.LF82_2362,iNRG857_1313.NRG857_17110,iYL1228.KPN_03811 BPD_transp_1 k59_59425_1 1173028.ANKO01000021_gene3793 2.98e-09 63.5 COG0827@1|root,COG1002@1|root,COG2810@1|root,COG0827@2|Bacteria,COG1002@2|Bacteria,COG2810@2|Bacteria,1G051@1117|Cyanobacteria,1HBP5@1150|Oscillatoriales 1117|Cyanobacteria V Type II restriction enzyme - - - - - - - - - - - - Eco57I,N6_Mtase,TaqI_C k59_285336_1 391626.OAN307_c35030 4.48e-32 135.0 COG2931@1|root,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,2TRVY@28211|Alphaproteobacteria 28211|Alphaproteobacteria Q COG2931 RTX toxins and related Ca2 -binding proteins - - - - - - - - - - - - HemolysinCabind k59_172375_1 926569.ANT_04530 1.12e-91 292.0 COG0542@1|root,COG0542@2|Bacteria,2G5RA@200795|Chloroflexi 200795|Chloroflexi O ATPase AAA-2 domain protein clpC - - ko:K03696 ko01100,map01100 - - - ko00000,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N,HTH_17,UVR k59_1132503_1 1123320.KB889696_gene9133 1e-95 290.0 COG0183@1|root,COG0183@2|Bacteria,2GJ0W@201174|Actinobacteria 201174|Actinobacteria I Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation - - 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - - - k59_1019847_1 1131266.ARWQ01000001_gene1251 3.25e-11 63.5 COG0750@1|root,arCOG04064@2157|Archaea,41SW5@651137|Thaumarchaeota 651137|Thaumarchaeota M Peptidase family M50 - - - - - - - - - - - - PDZ_2,Peptidase_M50 k59_1019847_2 436308.Nmar_0108 1e-47 154.0 COG1324@1|root,arCOG04231@2157|Archaea,41SR4@651137|Thaumarchaeota 651137|Thaumarchaeota P PFAM CutA1 divalent ion tolerance protein - - - ko:K03926 - - - - ko00000 - - - CutA1 k59_1019847_3 436308.Nmar_0109 9.58e-18 81.3 COG1537@1|root,arCOG01741@2157|Archaea,41S6V@651137|Thaumarchaeota 651137|Thaumarchaeota J May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity pelA - - ko:K06965 ko03015,map03015 - - - ko00000,ko00001 - - - eRF1_1,eRF1_3 k59_398157_1 1217718.ALOU01000041_gene24 1.52e-23 99.8 COG2183@1|root,COG2183@2|Bacteria,1MUA7@1224|Proteobacteria,2VH6A@28216|Betaproteobacteria,1K0R2@119060|Burkholderiaceae 28216|Betaproteobacteria K SMART Resolvase, RNase H domain protein fold tex - - ko:K06959 - - - - ko00000 - - - HHH_3,S1,Tex_N,Tex_YqgF k59_1584357_1 1415778.JQMM01000001_gene623 6.57e-75 238.0 COG1301@1|root,COG1301@2|Bacteria,1MU0Q@1224|Proteobacteria,1RMEN@1236|Gammaproteobacteria,1J4SX@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria U Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family gltP - - ko:K03309 - - - - ko00000 2.A.23 - - SDF k59_1075755_1 419610.Mext_0045 1.43e-10 63.5 COG2207@1|root,COG2207@2|Bacteria,1MX23@1224|Proteobacteria,2U3ZY@28211|Alphaproteobacteria,1JZ61@119045|Methylobacteriaceae 28211|Alphaproteobacteria K PFAM helix-turn-helix- domain containing protein AraC type - - - - - - - - - - - - Arabinose_bd,HTH_18 k59_341846_1 1216007.AOPM01000105_gene14 2.84e-74 230.0 COG0218@1|root,COG0218@2|Bacteria,1MY3Z@1224|Proteobacteria,1RNJP@1236|Gammaproteobacteria,2Q04B@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria D Necessary for normal cell division and for the maintenance of normal septation engB GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0017076,GO:0019001,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - ko:K03978 - - - - ko00000,ko03036 - - - MMR_HSR1 k59_228516_1 316407.85676515 1.37e-109 333.0 COG2199@1|root,COG2200@1|root,COG2199@2|Bacteria,COG2200@2|Bacteria,1RGCV@1224|Proteobacteria,1S1IZ@1236|Gammaproteobacteria,3XNZ7@561|Escherichia 1236|Gammaproteobacteria T 3',5'-cyclic diguanylic acid metabolic process yhjK GO:0003674,GO:0003824,GO:0004112,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008081,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009187,GO:0009190,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016787,GO:0016788,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0042578,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044464,GO:0046390,GO:0046483,GO:0052652,GO:0052653,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 - - - - - - - - - - EAL,GAPES3,GGDEF,HAMP k59_511041_1 1122137.AQXF01000002_gene502 3.43e-129 385.0 COG1154@1|root,COG1154@2|Bacteria,1MUSJ@1224|Proteobacteria,2TRDD@28211|Alphaproteobacteria 28211|Alphaproteobacteria H Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) dxs - 2.2.1.7 ko:K01662 ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130 M00096 R05636 RC00032 ko00000,ko00001,ko00002,ko01000 - - - DXP_synthase_N,Transket_pyr,Transketolase_C k59_1471557_1 997346.HMPREF9374_0025 5.94e-25 107.0 COG1262@1|root,COG1262@2|Bacteria,1TT4R@1239|Firmicutes,4HA8D@91061|Bacilli 91061|Bacilli S Sulfatase-modifying factor enzyme 1 pkn1 - - - - - - - - - - - FGE-sulfatase k59_1753932_1 501479.ACNW01000058_gene4416 2e-48 171.0 COG0031@1|root,COG0031@2|Bacteria,1MUBE@1224|Proteobacteria,2TS33@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Cysteine synthase - - 2.5.1.47 ko:K01738 ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230 M00021 R00897,R03601,R04859 RC00020,RC02814,RC02821 ko00000,ko00001,ko00002,ko01000 - - - Glutaredoxin,PALP k59_454600_2 648757.Rvan_3041 1.63e-19 85.9 COG2954@1|root,COG2954@2|Bacteria,1RI38@1224|Proteobacteria,2UD6M@28211|Alphaproteobacteria,3N7A0@45401|Hyphomicrobiaceae 28211|Alphaproteobacteria S CYTH - - 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 - - - CYTH k59_454616_1 1296990.H845_1216 2.74e-66 214.0 COG0160@1|root,COG0160@2|Bacteria,1MWY6@1224|Proteobacteria,2TUDG@28211|Alphaproteobacteria,2JQQB@204441|Rhodospirillales 204441|Rhodospirillales E Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family - - 2.6.1.19,2.6.1.22 ko:K07250 ko00250,ko00280,ko00410,ko00640,ko00650,ko01100,ko01120,map00250,map00280,map00410,map00640,map00650,map01100,map01120 M00027 R00908,R01648,R04188 RC00006,RC00062,RC00160 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 k59_1471580_1 713586.KB900536_gene1937 2.32e-65 215.0 COG0154@1|root,COG0154@2|Bacteria,1MUVQ@1224|Proteobacteria,1RP7E@1236|Gammaproteobacteria,1WWC9@135613|Chromatiales 135613|Chromatiales J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) - - - - - - - - - - - - Amidase k59_511073_1 225849.swp_2116 1.19e-62 217.0 COG2843@1|root,COG2843@2|Bacteria,1P1MG@1224|Proteobacteria,1RSI9@1236|Gammaproteobacteria,2QDEB@267890|Shewanellaceae 1236|Gammaproteobacteria M Bacterial capsule synthesis protein PGA_cap - - - ko:K07282 - - - - ko00000 - - - PGA_cap k59_511073_2 1333507.AUTQ01000176_gene1414 1.83e-07 51.6 COG0583@1|root,COG0583@2|Bacteria,1MX2A@1224|Proteobacteria,1RQ5Y@1236|Gammaproteobacteria,2Q1XE@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria K LysR substrate binding domain nocR - - - - - - - - - - - HTH_1,LysR_substrate k59_1697509_1 1144307.PMI04_00182 1.99e-134 396.0 COG1541@1|root,COG1541@2|Bacteria,1NT0G@1224|Proteobacteria,2UP2C@28211|Alphaproteobacteria,2K9AS@204457|Sphingomonadales 204457|Sphingomonadales H Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA) - - - - - - - - - - - - - k59_1471592_1 1267005.KB911256_gene1726 3.72e-13 66.6 2E6IZ@1|root,33162@2|Bacteria,1N85B@1224|Proteobacteria,2UH5M@28211|Alphaproteobacteria,3N9BX@45401|Hyphomicrobiaceae 28211|Alphaproteobacteria S Domain of unknown function (DUF4326) - - - - - - - - - - - - DUF4326 k59_2627_1 595593.JREV01000045_gene686 2.7e-12 71.6 COG0477@1|root,COG2814@2|Bacteria,2H0CW@201174|Actinobacteria,1W8M8@1268|Micrococcaceae 201174|Actinobacteria EGP Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 k59_172451_1 1229909.NSED_01300 6.18e-97 293.0 COG1005@1|root,arCOG01546@2157|Archaea,41SAT@651137|Thaumarchaeota 651137|Thaumarchaeota C NADH dehydrogenase - - 1.6.5.3 ko:K00337 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - NADHdh k59_1302235_1 1123504.JQKD01000003_gene567 8.68e-93 294.0 COG0366@1|root,COG0366@2|Bacteria,1MWBZ@1224|Proteobacteria,2VK9R@28216|Betaproteobacteria,4AD7Y@80864|Comamonadaceae 28216|Betaproteobacteria G Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB glgE - 2.4.99.16 ko:K16147 ko00500,ko01100,map00500,map01100 - R09994 - ko00000,ko00001,ko01000 - GH13 - Alpha-amylase,DUF3416 k59_116020_1 1528106.JRJE01000003_gene887 5.97e-14 72.0 COG0679@1|root,COG0679@2|Bacteria,1P2SH@1224|Proteobacteria,2TSPG@28211|Alphaproteobacteria,2JRPX@204441|Rhodospirillales 204441|Rhodospirillales S Membrane transport protein - - - ko:K07088 - - - - ko00000 - - - Mem_trans k59_116020_2 1415779.JOMH01000001_gene2885 1.46e-21 95.9 COG1115@1|root,COG1115@2|Bacteria,1MUI3@1224|Proteobacteria,1RMNF@1236|Gammaproteobacteria,1X57M@135614|Xanthomonadales 135614|Xanthomonadales E Sodium alanine symporter - - - ko:K03310 - - - - ko00000 2.A.25 - - Na_Ala_symp k59_511086_1 1195246.AGRI_01430 1.55e-86 286.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,464X3@72275|Alteromonadaceae 1236|Gammaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran,DUF805 k59_1414959_1 1122137.AQXF01000001_gene3101 3.17e-142 429.0 COG1629@1|root,COG4774@1|root,COG1629@2|Bacteria,COG4774@2|Bacteria,1NMCN@1224|Proteobacteria,2TW2G@28211|Alphaproteobacteria 28211|Alphaproteobacteria P receptor - - - - - - - - - - - - Plug,TonB_dep_Rec k59_863198_2 977880.RALTA_A2256 7.09e-52 174.0 COG0235@1|root,COG0235@2|Bacteria,1MWP9@1224|Proteobacteria,2VKWQ@28216|Betaproteobacteria,1JZNW@119060|Burkholderiaceae 28216|Betaproteobacteria G Class II aldolase adducin family protein - - - - - - - - - - - - Aldolase_II k59_579577_1 904293.HMPREF9176_0543 2.36e-43 156.0 COG1131@1|root,COG1131@2|Bacteria,1TP4J@1239|Firmicutes,4HBGH@91061|Bacilli 91061|Bacilli V abc transporter atp-binding protein bcrA - - ko:K20459 ko02010,map02010 M00813 - - ko00000,ko00001,ko00002,ko02000 3.A.1.124.3,3.A.1.124.4,3.A.1.124.5 - - ABC_tran k59_15071_1 1165096.ARWF01000001_gene2241 2.33e-126 369.0 COG5008@1|root,COG5008@2|Bacteria,1QTTX@1224|Proteobacteria,2VIWS@28216|Betaproteobacteria,2KKV0@206350|Nitrosomonadales 206350|Nitrosomonadales NU PFAM type II secretion system protein E - - - ko:K02670 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE k59_1484456_2 1122137.AQXF01000003_gene2349 1.57e-18 84.7 COG0564@1|root,COG0564@2|Bacteria,1MUBN@1224|Proteobacteria,2TSBK@28211|Alphaproteobacteria 28211|Alphaproteobacteria J Responsible for synthesis of pseudouridine from uracil rluD GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360 5.4.99.23 ko:K06180 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2,S4 k59_636100_2 1184609.KILIM_042_00240 2.38e-20 89.7 COG1595@1|root,COG1595@2|Bacteria,2IRNG@201174|Actinobacteria 201174|Actinobacteria K belongs to the sigma-70 factor family, ECF subfamily - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 k59_863205_1 1382356.JQMP01000001_gene835 1.03e-27 114.0 COG1239@1|root,COG1239@2|Bacteria,2GB7G@200795|Chloroflexi,27XRK@189775|Thermomicrobia 189775|Thermomicrobia H Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX - - 6.6.1.1 ko:K03405 ko00860,ko01100,ko01110,map00860,map01100,map01110 - R03877 RC01012 ko00000,ko00001,ko01000 - - - - k59_354410_1 316407.85674802 6.45e-94 274.0 COG1832@1|root,COG1832@2|Bacteria,1N03D@1224|Proteobacteria,1S3T2@1236|Gammaproteobacteria,3XPIE@561|Escherichia 1236|Gammaproteobacteria S cofactor binding yccU GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - ko:K06929 - - - - ko00000 - - - CoA_binding_2 k59_1484458_2 1229909.NSED_09705 2.69e-176 496.0 COG1405@1|root,arCOG01981@2157|Archaea 2157|Archaea K Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB) tfb - - ko:K03124 ko03022,ko05169,ko05203,map03022,map05169,map05203 - - - ko00000,ko00001,ko03021 - - - TFIIB,TF_Zn_Ribbon k59_354415_1 266265.Bxe_A4189 2.47e-34 130.0 COG0004@1|root,COG0004@2|Bacteria,1NR9F@1224|Proteobacteria,2VJ8B@28216|Betaproteobacteria,1K0BN@119060|Burkholderiaceae 28216|Betaproteobacteria P Ammonium transporter amt - - ko:K03320 - - - - ko00000,ko02000 1.A.11 - - Ammonium_transp k59_354415_2 1207063.P24_03286 2.02e-58 182.0 COG0347@1|root,COG0347@2|Bacteria,1RGWK@1224|Proteobacteria,2U952@28211|Alphaproteobacteria,2JSPI@204441|Rhodospirillales 204441|Rhodospirillales K Belongs to the P(II) protein family - - - ko:K04752 - - - - ko00000 - - - P-II k59_1257457_1 387631.Asulf_02173 2.04e-10 67.0 COG0582@1|root,arCOG01241@2157|Archaea,2XUBA@28890|Euryarchaeota 28890|Euryarchaeota L integrase family - - - ko:K04763 - - - - ko00000,ko03036 - - - Phage_int_SAM_4,Phage_integrase k59_1485398_1 1122137.AQXF01000005_gene1311 1.21e-08 64.3 COG2931@1|root,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,2TRVY@28211|Alphaproteobacteria 28211|Alphaproteobacteria Q COG2931 RTX toxins and related Ca2 -binding proteins - - - - - - - - - - - - HemolysinCabind k59_73182_1 1229909.NSED_09430 4.79e-108 331.0 arCOG02322@1|root,arCOG07810@1|root,arCOG02322@2157|Archaea,arCOG07810@2157|Archaea,41T0S@651137|Thaumarchaeota 651137|Thaumarchaeota N Adenylate guanylate cyclase with integral membrane sensor - - - - - - - - - - - - Guanylate_cyc,HAMP k59_919587_1 335659.S23_06530 4.58e-20 92.0 COG1622@1|root,COG1622@2|Bacteria,1MWHZ@1224|Proteobacteria,2U0IR@28211|Alphaproteobacteria,3JUA6@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria C COX Aromatic Rich Motif cyoA - 1.10.3.10 ko:K02297 ko00190,ko01100,map00190,map01100 M00417 R11335 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.4.5 - - COX2,COX_ARM k59_919587_2 1123270.ATUR01000002_gene2321 9.84e-15 73.9 COG0843@1|root,COG0843@2|Bacteria,1MU7S@1224|Proteobacteria,2TQP1@28211|Alphaproteobacteria,2K0Q3@204457|Sphingomonadales 204457|Sphingomonadales C Belongs to the heme-copper respiratory oxidase family cyoB - 1.10.3.10 ko:K02298 ko00190,ko01100,map00190,map01100 M00417 R11335 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.4.5 - - COX1 k59_1145336_1 883078.HMPREF9695_01751 1.37e-07 50.4 COG0346@1|root,COG0346@2|Bacteria,1RCYX@1224|Proteobacteria,2U7A8@28211|Alphaproteobacteria,3JVYC@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria E Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily gloA GO:0003674,GO:0003824,GO:0004462,GO:0006518,GO:0006575,GO:0006749,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016829,GO:0016846,GO:0034641,GO:0043603,GO:0044237,GO:0051186,GO:0071704,GO:1901564 4.4.1.5 ko:K01759 ko00620,map00620 - R02530 RC00004,RC00740 ko00000,ko00001,ko01000 - - - Glyoxalase k59_1145336_2 859657.RPSI07_mp1755 1.66e-28 114.0 COG2199@1|root,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria,2VMMZ@28216|Betaproteobacteria,1JZWZ@119060|Burkholderiaceae 28216|Betaproteobacteria T response regulator - - 2.7.7.65 ko:K11444 ko02020,ko02025,map02020,map02025 M00509 - - ko00000,ko00001,ko00002,ko01000,ko02022 - - - GGDEF,Response_reg k59_299022_1 886377.Murru_2743 1.1e-11 63.9 COG2197@1|root,COG2197@2|Bacteria,4NMX5@976|Bacteroidetes,1I1G5@117743|Flavobacteriia 976|Bacteroidetes T COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain - - - - - - - - - - - - GerE,Response_reg k59_299022_2 436229.JOEH01000021_gene7767 7.8e-09 60.1 COG4585@1|root,COG4585@2|Bacteria,2GQQ8@201174|Actinobacteria,2NFTT@228398|Streptacidiphilus 201174|Actinobacteria T Histidine kinase - - - - - - - - - - - - HisKA_3 k59_1485402_1 1214065.BAGV01000029_gene632 1.57e-66 216.0 COG0008@1|root,COG0008@2|Bacteria,1MUN7@1224|Proteobacteria,1RMYQ@1236|Gammaproteobacteria 1236|Gammaproteobacteria J Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon gluQ GO:0000166,GO:0002097,GO:0003674,GO:0005488,GO:0005524,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008144,GO:0008150,GO:0008152,GO:0008270,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034470,GO:0034641,GO:0034660,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901363 - ko:K01894 - - - - ko00000,ko01000,ko01007,ko03016 - - - tRNA-synt_1c k59_1145341_1 316407.1799614 7.11e-137 397.0 COG0318@1|root,COG0318@2|Bacteria,1MW0Y@1224|Proteobacteria,1RN35@1236|Gammaproteobacteria,3XNGV@561|Escherichia 1236|Gammaproteobacteria H Belongs to the ATP-dependent AMP-binding enzyme family. MenE subfamily menE GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006732,GO:0008150,GO:0008152,GO:0008756,GO:0009058,GO:0009108,GO:0009233,GO:0009234,GO:0009987,GO:0016043,GO:0016405,GO:0016874,GO:0016877,GO:0016878,GO:0022607,GO:0042180,GO:0042181,GO:0042802,GO:0043933,GO:0044085,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0051186,GO:0051188,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0065003,GO:0071704,GO:0071840,GO:1901576,GO:1901661,GO:1901663 6.2.1.26 ko:K00666,ko:K01911 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116 R04030 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004 - - iECNA114_1301.ECNA114_2354,iECSF_1327.ECSF_2141,iEcE24377_1341.EcE24377A_2556,iEcHS_1320.EcHS_A2406,iLF82_1304.LF82_1314,iNRG857_1313.NRG857_11465 AMP-binding,AMP-binding_C k59_1145341_2 316407.85675330 1.94e-19 85.1 COG1441@1|root,COG1441@2|Bacteria,1MV33@1224|Proteobacteria,1RRC0@1236|Gammaproteobacteria,3XNDA@561|Escherichia 1236|Gammaproteobacteria H Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB) menC GO:0003674,GO:0003824,GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009233,GO:0009234,GO:0009987,GO:0016829,GO:0016835,GO:0016836,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901661,GO:1901663 4.2.1.113 ko:K02549 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116 R04031 RC01053 ko00000,ko00001,ko00002,ko01000 - - iE2348C_1286.E2348C_2406,iSbBS512_1146.SbBS512_E2640 MR_MLE_C k59_523623_1 1453501.JELR01000005_gene1704 9.21e-56 187.0 COG0340@1|root,COG1654@1|root,COG0340@2|Bacteria,COG1654@2|Bacteria,1MWCC@1224|Proteobacteria,1RNGC@1236|Gammaproteobacteria,465FU@72275|Alteromonadaceae 1236|Gammaproteobacteria K Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon birA GO:0000166,GO:0000976,GO:0000984,GO:0001017,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003824,GO:0004077,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0006082,GO:0006464,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009305,GO:0009374,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0017053,GO:0017076,GO:0017144,GO:0018130,GO:0018271,GO:0019538,GO:0019752,GO:0019842,GO:0030554,GO:0031406,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0032991,GO:0033218,GO:0033293,GO:0034641,GO:0035639,GO:0036094,GO:0036211,GO:0042364,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043565,GO:0043603,GO:0043604,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0046983,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901681,GO:1990837 6.3.4.15 ko:K03524 ko00780,ko01100,map00780,map01100 - R01074,R05145 RC00043,RC00070,RC00096,RC02896 ko00000,ko00001,ko01000,ko03000 - - - BPL_C,BPL_LplA_LipB,HTH_11 k59_1033666_1 1380391.JIAS01000011_gene4731 1.94e-89 277.0 COG2816@1|root,COG2816@2|Bacteria,1MV1F@1224|Proteobacteria,2TTRT@28211|Alphaproteobacteria,2JQZX@204441|Rhodospirillales 204441|Rhodospirillales L COG1180 Pyruvate-formate lyase-activating enzyme - - - - - - - - - - - - - k59_241624_1 469383.Cwoe_1042 1.6e-55 196.0 COG0508@1|root,COG0567@1|root,COG0508@2|Bacteria,COG0567@2|Bacteria,2GIU6@201174|Actinobacteria,4CPG1@84995|Rubrobacteria 84995|Rubrobacteria C 2-oxoglutarate dehydrogenase C-terminal - - 1.2.4.2 ko:K00164 ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00032 R00621,R01933,R01940,R03316,R08549 RC00004,RC00027,RC00627,RC02743,RC02833,RC02883 br01601,ko00000,ko00001,ko00002,ko01000 - - - 2-oxoacid_dh,2-oxogl_dehyd_N,Biotin_lipoyl,E1_dh,E3_binding,OxoGdeHyase_C,Transket_pyr k59_1145363_1 1128421.JAGA01000002_gene1140 5.11e-90 279.0 COG4799@1|root,COG4799@2|Bacteria,2NQBT@2323|unclassified Bacteria 2|Bacteria I Carboxyl transferase domain mccB - 2.1.3.15,6.4.1.3,6.4.1.4 ko:K01969,ko:K15052 ko00280,ko00720,ko01100,ko01200,map00280,map00720,map01100,map01200 M00036,M00376 R01859,R04138 RC00097,RC00367,RC00609,RC00942 ko00000,ko00001,ko00002,ko01000 - - - Carboxyl_trans k59_919599_1 237727.NAP1_11298 7.67e-10 61.6 2C2VU@1|root,34305@2|Bacteria,1N3B4@1224|Proteobacteria,2UCFR@28211|Alphaproteobacteria,2K4VX@204457|Sphingomonadales 204457|Sphingomonadales - - - - - - - - - - - - - - DUF4136 k59_919599_2 1088721.NSU_0623 8.91e-35 128.0 COG2866@1|root,COG2866@2|Bacteria,1MUMN@1224|Proteobacteria,2TREN@28211|Alphaproteobacteria,2K01Q@204457|Sphingomonadales 204457|Sphingomonadales E Carboxypeptidase - - - - - - - - - - - - Peptidase_M14 k59_16049_1 1144305.PMI02_03801 9.31e-91 284.0 COG3975@1|root,COG3975@2|Bacteria,1MUHZ@1224|Proteobacteria,2TRZF@28211|Alphaproteobacteria,2K0CU@204457|Sphingomonadales 204457|Sphingomonadales S protease with the C-terminal PDZ - - - - - - - - - - - - Peptidase_M61 k59_1145375_1 296591.Bpro_4758 4.8e-06 49.7 COG3177@1|root,COG3177@2|Bacteria,1MV69@1224|Proteobacteria,2VKBI@28216|Betaproteobacteria,4A9KH@80864|Comamonadaceae 28216|Betaproteobacteria S filamentation induced by cAMP protein Fic - - - - - - - - - - - - DUF4172,Fic k59_1089142_1 1379698.RBG1_1C00001G0777 2.2e-109 345.0 COG2864@1|root,COG2864@2|Bacteria,2NQFM@2323|unclassified Bacteria 2|Bacteria P Prokaryotic cytochrome b561 cbcY - - - - - - - - - - - Cytochrom_c3_2,Cytochrome_C7,Ni_hydr_CYTB,Paired_CXXCH_1,Rhodanese k59_241637_1 1229909.NSED_08645 1.03e-96 293.0 COG0043@1|root,arCOG01671@2157|Archaea,41SEQ@651137|Thaumarchaeota 651137|Thaumarchaeota H UbiD family decarboxylase - - - - - - - - - - - - UbiD k59_750069_1 493475.GARC_2623 9.83e-94 288.0 COG0738@1|root,COG0738@2|Bacteria,1MXDC@1224|Proteobacteria,1RQX9@1236|Gammaproteobacteria,4659F@72275|Alteromonadaceae 1236|Gammaproteobacteria G Major Facilitator Superfamily fucP - - ko:K02429 - - - - ko00000,ko02000 2.A.1.7 - - MFS_1 k59_1315520_2 670292.JH26_14430 7.27e-27 106.0 2C2XN@1|root,32GT6@2|Bacteria,1REZE@1224|Proteobacteria,2U8HW@28211|Alphaproteobacteria,1JVMF@119045|Methylobacteriaceae 28211|Alphaproteobacteria S ERF superfamily - - - - - - - - - - - - ERF k59_1597662_1 1273125.Rrhod_2644 2.83e-55 184.0 COG0052@1|root,COG0052@2|Bacteria,2GMYC@201174|Actinobacteria,4FTWY@85025|Nocardiaceae 201174|Actinobacteria J Belongs to the universal ribosomal protein uS2 family rpsB GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0019538,GO:0022626,GO:0022627,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02967 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S2 k59_467506_1 1205680.CAKO01000027_gene4693 1.91e-05 45.8 COG1932@1|root,COG1932@2|Bacteria,1MUB5@1224|Proteobacteria,2TSHT@28211|Alphaproteobacteria,2JPS4@204441|Rhodospirillales 204441|Rhodospirillales EH Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine serC - 2.6.1.52 ko:K00831 ko00260,ko00680,ko00750,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map00750,map01100,map01120,map01130,map01200,map01230 M00020,M00124 R04173,R05085 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_5 k59_467506_2 1415778.JQMM01000001_gene610 7.19e-153 439.0 COG0111@1|root,COG0111@2|Bacteria,1MU5Z@1224|Proteobacteria,1RPEY@1236|Gammaproteobacteria,1J5JA@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family serA - 1.1.1.399,1.1.1.95 ko:K00058 ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230 M00020 R01513 RC00031 ko00000,ko00001,ko00002,ko01000,ko04147 - - - 2-Hacid_dh,2-Hacid_dh_C,ACT k59_1089152_1 1229780.BN381_310061 2.5e-86 266.0 COG0489@1|root,COG0489@2|Bacteria,2GJUZ@201174|Actinobacteria,3UWC1@52018|unclassified Actinobacteria (class) 201174|Actinobacteria D Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP mrp GO:0008150,GO:0040007 - ko:K03593 - - - - ko00000,ko03029,ko03036 - - - FeS_assembly_P,ParA k59_241652_1 1123270.ATUR01000006_gene166 4.01e-38 133.0 COG2128@1|root,COG2128@2|Bacteria,1PNA5@1224|Proteobacteria,2U80C@28211|Alphaproteobacteria,2KE30@204457|Sphingomonadales 204457|Sphingomonadales S Carboxymuconolactone decarboxylase family - - - - - - - - - - - - CMD k59_241652_2 1123270.ATUR01000006_gene167 7.05e-44 155.0 COG0477@1|root,COG2814@2|Bacteria,1NU31@1224|Proteobacteria,2U5M0@28211|Alphaproteobacteria 28211|Alphaproteobacteria EGP Major facilitator Superfamily - - - - - - - - - - - - MFS_1 k59_299064_1 1088721.NSU_4232 5.21e-50 159.0 COG0695@1|root,COG0695@2|Bacteria,1N72P@1224|Proteobacteria,2UFM1@28211|Alphaproteobacteria,2K5VT@204457|Sphingomonadales 204457|Sphingomonadales O Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins grxC - - ko:K03676 - - - - ko00000,ko03110 - - - Glutaredoxin k59_299064_2 1088721.NSU_4231 6e-91 268.0 COG0071@1|root,COG0071@2|Bacteria,1RH2X@1224|Proteobacteria,2U96D@28211|Alphaproteobacteria,2K4JU@204457|Sphingomonadales 204457|Sphingomonadales O Belongs to the small heat shock protein (HSP20) family ibpA - - ko:K04080 - - - - ko00000,ko03110 - - - HSP20 k59_1710659_1 1229909.NSED_09180 5.13e-178 502.0 COG0006@1|root,arCOG01000@2157|Archaea,41T14@651137|Thaumarchaeota 651137|Thaumarchaeota E Belongs to the peptidase M24B family - - 3.4.11.9,3.4.13.9 ko:K01262,ko:K01271 - - - - ko00000,ko01000,ko01002 - - - Creatinase_N,Peptidase_M24 k59_1315538_1 1408418.JNJH01000004_gene1993 3.07e-112 339.0 COG2252@1|root,COG2252@2|Bacteria,1QVW3@1224|Proteobacteria,2TWKP@28211|Alphaproteobacteria 28211|Alphaproteobacteria S PERMEase - - - ko:K06901 - - - - ko00000,ko02000 2.A.1.40 - - - k59_355670_1 103733.JNYO01000027_gene2413 7.6e-39 143.0 COG2355@1|root,COG2355@2|Bacteria,2GN82@201174|Actinobacteria,4DX4Y@85010|Pseudonocardiales 201174|Actinobacteria E Membrane dipeptidase (Peptidase family M19) Dpep - 3.4.13.19 ko:K01273 - - - - ko00000,ko00537,ko01000,ko01002,ko04147 - - - Peptidase_M19 k59_1767175_1 1096930.L284_05465 0.000648 41.2 COG1291@1|root,COG1291@2|Bacteria,1MXK3@1224|Proteobacteria,2TR5A@28211|Alphaproteobacteria,2K1GC@204457|Sphingomonadales 204457|Sphingomonadales N With MotB forms the ion channels that couple flagellar rotation to proton sodium motive force across the membrane and forms the stator elements of the rotary flagellar machine - - - ko:K02556 ko02020,ko02030,ko02040,map02020,map02030,map02040 - - - ko00000,ko00001,ko02000,ko02035 1.A.30.1 - - MotA_ExbB k59_1767175_2 1096930.L284_05470 3.53e-50 162.0 COG5442@1|root,COG5442@2|Bacteria,1N3N6@1224|Proteobacteria,2UC0Z@28211|Alphaproteobacteria,2K62X@204457|Sphingomonadales 204457|Sphingomonadales N Flagellar protein FlaF - - - ko:K06602 - - - - ko00000,ko02035 - - - FlaF k59_1485450_1 1229909.NSED_00100 1.1e-62 198.0 COG2138@1|root,arCOG02246@2157|Archaea,41SH6@651137|Thaumarchaeota 651137|Thaumarchaeota P Cobalt chelatase (CbiK) - - 5.4.99.60,5.4.99.61 ko:K06042 ko00860,ko01100,map00860,map01100 - R05177,R05814 RC01292,RC01980 ko00000,ko00001,ko01000 - - - CbiX k59_16074_1 203908.EGG11542 3.36e-53 183.0 COG0649@1|root,KOG2870@2759|Eukaryota,38E8K@33154|Opisthokonta,3NVGU@4751|Fungi,3UYFE@5204|Basidiomycota,2YCAW@29000|Pucciniomycotina 4751|Fungi C Respiratory-chain NADH dehydrogenase, 49 Kd subunit NdufS2 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0016020,GO:0019866,GO:0031090,GO:0031966,GO:0031967,GO:0031975,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464 1.6.5.3,1.6.99.3 ko:K03935 ko00190,ko01100,ko04714,ko04723,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map04714,map04723,map04932,map05010,map05012,map05016 M00143 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1.6 - - Complex1_49kDa k59_1202469_1 713586.KB900536_gene1379 1.48e-55 191.0 COG0768@1|root,COG0768@2|Bacteria,1MUNY@1224|Proteobacteria,1RNGW@1236|Gammaproteobacteria,1WWDS@135613|Chromatiales 135613|Chromatiales M Catalyzes cross-linking of the peptidoglycan cell wall at the division septum ftsI - 3.4.16.4 ko:K03587 ko00550,ko01501,map00550,map01501 - - - ko00000,ko00001,ko01000,ko01011,ko03036 - - - PBP_dimer,Transpeptidase k59_1485467_1 1150469.RSPPHO_02585 1.37e-57 190.0 28IJT@1|root,2Z8KN@2|Bacteria,1R6VB@1224|Proteobacteria,2TUCS@28211|Alphaproteobacteria,2JPQ9@204441|Rhodospirillales 204441|Rhodospirillales H Dinitrogenase reductase ADP-ribosyltransferase (DRAT) - - 2.4.2.37 ko:K05951 - - - - ko00000,ko01000 - - - DRAT k59_807204_2 1121935.AQXX01000138_gene3164 2.7e-53 174.0 28W7P@1|root,2ZI89@2|Bacteria,1N2SJ@1224|Proteobacteria,1SA34@1236|Gammaproteobacteria,1XQ8Q@135619|Oceanospirillales 135619|Oceanospirillales - - - - - - - - - - - - - - - k59_185829_1 338966.Ppro_1116 2.9e-10 57.8 COG3905@1|root,COG3905@2|Bacteria,1NHN3@1224|Proteobacteria,43237@68525|delta/epsilon subdivisions,2WW8W@28221|Deltaproteobacteria 28221|Deltaproteobacteria K PFAM CopG domain protein DNA-binding domain protein - - - - - - - - - - - - RHH_1 k59_185829_2 1121921.KB898715_gene42 4.6e-43 142.0 COG3668@1|root,COG3668@2|Bacteria 2|Bacteria D Plasmid stabilization system spsF - - ko:K19092 - - - - ko00000,ko02048 - - - ParE_toxin k59_693749_1 1500301.JQMF01000015_gene4851 1.04e-37 142.0 COG1807@1|root,COG1807@2|Bacteria,1PKMY@1224|Proteobacteria,2VC27@28211|Alphaproteobacteria,4BI00@82115|Rhizobiaceae 28211|Alphaproteobacteria M Dolichyl-phosphate-mannose-protein mannosyltransferase - - - - - - - - - - - - PMT_2 k59_129298_1 1242864.D187_000364 2.79e-89 287.0 COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,42M2R@68525|delta/epsilon subdivisions,2WJ4J@28221|Deltaproteobacteria,2YTUI@29|Myxococcales 28221|Deltaproteobacteria P copper-translocating P-type ATPase copF - 3.6.3.54 ko:K17686 ko01524,ko04016,map01524,map04016 - R00086 RC00002 ko00000,ko00001,ko01000 3.A.3.5 - - E1-E2_ATPase,HMA,Hydrolase,YHS k59_185841_1 463191.SSEG_02882 4e-21 94.7 COG0705@1|root,COG0705@2|Bacteria,2GNPK@201174|Actinobacteria 201174|Actinobacteria S PFAM Rhomboid family protein - - - - - - - - - - - - Rhomboid k59_1258608_1 1265503.KB905175_gene3956 1.05e-104 315.0 COG2355@1|root,COG2355@2|Bacteria,1MWEW@1224|Proteobacteria,1RQGU@1236|Gammaproteobacteria,2Q7FM@267889|Colwelliaceae 1236|Gammaproteobacteria E Membrane dipeptidase (Peptidase family M19) acdP - 3.4.13.19 ko:K01273 - - - - ko00000,ko00537,ko01000,ko01002,ko04147 - - - Peptidase_M19 k59_807225_1 396588.Tgr7_2124 6.09e-62 216.0 COG1074@1|root,COG1074@2|Bacteria,1MUTF@1224|Proteobacteria,1RPC6@1236|Gammaproteobacteria,1WWH2@135613|Chromatiales 135613|Chromatiales L A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit contributes ATPase, 3'-5' helicase, exonuclease activity and loads RecA onto ssDNA recB - 3.1.11.5,3.6.4.12 ko:K03582,ko:K16898 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - PDDEXK_1,UvrD-helicase,UvrD_C k59_1372376_1 1123037.AUDE01000033_gene3468 5.81e-87 270.0 COG0696@1|root,COG0696@2|Bacteria,4NEQT@976|Bacteroidetes,1HWJU@117743|Flavobacteriia 976|Bacteroidetes G Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate gpmI - 5.4.2.12 ko:K15633 ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003 R01518 RC00536 ko00000,ko00001,ko00002,ko01000 - - - Metalloenzyme,Phosphodiest,iPGM_N k59_693780_1 1163617.SCD_n02125 0.000134 43.1 COG4966@1|root,COG4966@2|Bacteria,1RH2G@1224|Proteobacteria,2VT5C@28216|Betaproteobacteria 28216|Betaproteobacteria NU Type IV Pilus-assembly protein W - - - ko:K02672 - - - - ko00000,ko02035,ko02044 - - - N_methyl,PilW k59_693780_2 640081.Dsui_3491 3.04e-25 103.0 COG4726@1|root,COG4726@2|Bacteria,1N9CE@1224|Proteobacteria,2VWPP@28216|Betaproteobacteria,2KXMR@206389|Rhodocyclales 206389|Rhodocyclales NU Pilus assembly protein PilX - - - - - - - - - - - - - k59_580791_1 1121861.KB899941_gene3848 2.73e-26 104.0 COG5553@1|root,COG5553@2|Bacteria,1RBE3@1224|Proteobacteria,2VG78@28211|Alphaproteobacteria,2JX4K@204441|Rhodospirillales 204441|Rhodospirillales S Cysteine dioxygenase type I - - - - - - - - - - - - - k59_580791_2 38833.XP_003059330.1 0.000245 46.6 COG2126@1|root,KOG1545@2759|Eukaryota 2759|Eukaryota J voltage-gated potassium channel activity - - - - - - - - - - - - Ion_trans k59_1767228_1 1122137.AQXF01000003_gene2366 7.04e-131 387.0 COG0644@1|root,COG2440@1|root,COG0644@2|Bacteria,COG2440@2|Bacteria,1MVU6@1224|Proteobacteria,2TS0R@28211|Alphaproteobacteria 28211|Alphaproteobacteria C electron transfer flavoprotein-ubiquinone oxidoreductase etf - 1.5.5.1 ko:K00311 - - - - ko00000,ko01000 - - - ETF_QO,FAD_binding_2,NAD_binding_8 k59_467576_1 266117.Rxyl_0998 5.32e-33 129.0 COG0150@1|root,COG0150@2|Bacteria,2GJNY@201174|Actinobacteria,4CP9S@84995|Rubrobacteria 84995|Rubrobacteria F AIR synthase related protein, C-terminal domain purM - 6.3.3.1 ko:K01933 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04208 RC01100 ko00000,ko00001,ko00002,ko01000 - - - AIRS,AIRS_C k59_411258_1 493475.GARC_2863 9.01e-85 265.0 COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,1RM93@1236|Gammaproteobacteria,464E8@72275|Alteromonadaceae 1236|Gammaproteobacteria I Belongs to the thiolase family atoB - 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N k59_73278_1 1122137.AQXF01000006_gene677 3.75e-32 114.0 COG5572@1|root,COG5572@2|Bacteria,1MZ6Q@1224|Proteobacteria,2UJ9X@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Predicted integral membrane protein (DUF2282) - - - - - - - - - - - - DUF2282 k59_73278_2 1122137.AQXF01000006_gene676 1.61e-49 167.0 COG3220@1|root,COG3220@2|Bacteria,1MURE@1224|Proteobacteria,2TRZJ@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Belongs to the UPF0276 family - - - ko:K09930 - - - - ko00000 - - - DUF692 k59_467578_1 930171.Asphe3_34630 2.21e-15 80.1 COG1454@1|root,COG1454@2|Bacteria,2I2FD@201174|Actinobacteria 201174|Actinobacteria C alcohol dehydrogenase - - 1.1.1.1 ko:K00001 ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220 - R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310 RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273 ko00000,ko00001,ko01000 - - - Fe-ADH k59_467578_2 1122137.AQXF01000006_gene703 1.01e-118 345.0 COG1028@1|root,COG1028@2|Bacteria,1MUEV@1224|Proteobacteria,2TRCF@28211|Alphaproteobacteria 28211|Alphaproteobacteria IQ Acetoacetyl-CoA reductase - - 1.1.1.100 ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 k59_693800_1 1348635.BBJY01000011_gene1245 4.06e-27 115.0 COG5297@1|root,COG5297@2|Bacteria,1NDMY@1224|Proteobacteria,1RN6M@1236|Gammaproteobacteria,1XVBU@135623|Vibrionales 135623|Vibrionales G Carbohydrate binding domain - - - - - - - - - - - - CBM_4_9,CelD_N,Glyco_hydro_9 k59_73301_1 246197.MXAN_0712 9.46e-10 61.2 COG0745@1|root,COG0784@1|root,COG0840@1|root,COG2199@1|root,COG2770@1|root,COG5002@1|root,COG0745@2|Bacteria,COG0784@2|Bacteria,COG0840@2|Bacteria,COG2770@2|Bacteria,COG3706@2|Bacteria,COG5002@2|Bacteria,1NC9X@1224|Proteobacteria,43BZ2@68525|delta/epsilon subdivisions,2X79T@28221|Deltaproteobacteria,2YU1H@29|Myxococcales 28221|Deltaproteobacteria T HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - - - - - - - - - - - GAF_2,HATPase_c,HisKA,Response_reg k59_1381652_1 710696.Intca_0327 2.57e-07 57.8 COG1520@1|root,COG1520@2|Bacteria,2IAZ2@201174|Actinobacteria,4FIAP@85021|Intrasporangiaceae 201174|Actinobacteria S PQQ-like domain - - 1.1.2.6,2.7.11.1 ko:K05889,ko:K12132 - - R03136 - ko00000,ko01000,ko01001 - - - PQQ,PQQ_2,PQQ_3,Pkinase k59_589901_1 1121937.AUHJ01000014_gene2628 3.33e-07 52.4 COG1290@1|root,COG2857@1|root,COG1290@2|Bacteria,COG2857@2|Bacteria,1MV97@1224|Proteobacteria,1RNCP@1236|Gammaproteobacteria,465NG@72275|Alteromonadaceae 1236|Gammaproteobacteria C Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis petB - - ko:K00412 ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016 M00151,M00152 - - ko00000,ko00001,ko00002,ko03029 - - - Cytochrom_B_C,Cytochrom_C1,Cytochrome_B k59_589901_2 1121015.N789_02885 1.27e-32 122.0 COG2857@1|root,COG2857@2|Bacteria,1QFU2@1224|Proteobacteria,1RN4Y@1236|Gammaproteobacteria,1X4Q1@135614|Xanthomonadales 135614|Xanthomonadales C cytochrome petC - - ko:K00413 ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016 M00151,M00152 - - ko00000,ko00001,ko00002 - - - Cytochrom_C1 k59_814508_1 864069.MicloDRAFT_00005150 1.09e-112 335.0 COG2826@1|root,COG2826@2|Bacteria,1PP49@1224|Proteobacteria,2TRVA@28211|Alphaproteobacteria,1JVDJ@119045|Methylobacteriaceae 28211|Alphaproteobacteria L PFAM Integrase catalytic region - - - - - - - - - - - - HTH_38,rve k59_814508_2 553217.ENHAE0001_1701 5.31e-13 68.6 COG2801@1|root,COG2801@2|Bacteria,1MVXQ@1224|Proteobacteria,1RR4F@1236|Gammaproteobacteria,3NM1D@468|Moraxellaceae 1236|Gammaproteobacteria L HTH-like domain - - - ko:K07497 - - - - ko00000 - - - HTH_21,rve k59_1211632_1 1121104.AQXH01000001_gene1639 2.03e-76 244.0 COG1574@1|root,COG1574@2|Bacteria,4NFMV@976|Bacteroidetes,1IPIC@117747|Sphingobacteriia 976|Bacteroidetes S Amidohydrolase family - - - - - - - - - - - - Amidohydro_3 k59_1551354_1 931627.MycrhDRAFT_3695 6.15e-39 146.0 COG2303@1|root,COG2303@2|Bacteria,2GJAU@201174|Actinobacteria,233HY@1762|Mycobacteriaceae 201174|Actinobacteria E Belongs to the GMC oxidoreductase family - - - - - - - - - - - - GMC_oxred_C,GMC_oxred_N k59_530980_1 700015.Corgl_0238 7.36e-24 102.0 COG1105@1|root,COG1105@2|Bacteria,2GK7E@201174|Actinobacteria,4CVRS@84998|Coriobacteriia 84998|Coriobacteriia H Belongs to the carbohydrate kinase PfkB family - - 2.7.1.56 ko:K00882 ko00051,map00051 - R02071 RC00002,RC00017 ko00000,ko00001,ko01000 - - - PfkB k59_873584_1 28229.ND2E_2330 7.19e-33 130.0 COG1404@1|root,COG1404@2|Bacteria,1MVJE@1224|Proteobacteria,1RQ2M@1236|Gammaproteobacteria,2Q6SR@267889|Colwelliaceae 1236|Gammaproteobacteria O Belongs to the peptidase S8 family - - - - - - - - - - - - Inhibitor_I9,PA,Peptidase_S8 k59_1607432_1 797304.Natgr_3598 3.5e-05 50.4 COG0558@1|root,arCOG00670@2157|Archaea,2XWJ0@28890|Euryarchaeota,23V82@183963|Halobacteria 183963|Halobacteria I Belongs to the CDP-alcohol phosphatidyltransferase class-I family pgsA - 2.7.8.39 ko:K17884 - - R10464 RC00002,RC00078 ko00000,ko01000 - - - CDP-OH_P_transf k59_1720158_1 641524.ADICYQ_4751 2.54e-39 145.0 COG3866@1|root,COG3866@2|Bacteria,4P09P@976|Bacteroidetes,47MVU@768503|Cytophagia 976|Bacteroidetes G Pectate lyase - - - - - - - - - - - - - k59_25597_1 1173024.KI912153_gene183 2.56e-06 51.2 COG3119@1|root,COG3119@2|Bacteria,1G3QV@1117|Cyanobacteria 1117|Cyanobacteria P COG3119 Arylsulfatase A and related enzymes - - 3.1.6.1 ko:K01130 ko00140,ko00600,map00140,map00600 - R03980,R04856 RC00128,RC00231 ko00000,ko00001,ko01000 - - - Sulfatase k59_1435717_1 215803.DB30_8172 7.37e-51 181.0 COG2518@1|root,COG2518@2|Bacteria,1QX9V@1224|Proteobacteria,42Z9X@68525|delta/epsilon subdivisions,2WUEX@28221|Deltaproteobacteria,2YX7N@29|Myxococcales 28221|Deltaproteobacteria O Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins - - - - - - - - - - - - - k59_138362_1 1254432.SCE1572_32715 2.82e-131 390.0 COG0129@1|root,COG0129@2|Bacteria,1MUTQ@1224|Proteobacteria,42N3P@68525|delta/epsilon subdivisions,2WJB7@28221|Deltaproteobacteria,2YWT1@29|Myxococcales 28221|Deltaproteobacteria H Belongs to the IlvD Edd family ilvD - 4.2.1.9 ko:K01687 ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R01209,R04441,R05070 RC00468,RC01714 ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_1259 ILVD_EDD k59_983140_1 1122137.AQXF01000002_gene39 1.78e-153 439.0 COG0226@1|root,COG0226@2|Bacteria,1MUH9@1224|Proteobacteria,2TR1C@28211|Alphaproteobacteria 28211|Alphaproteobacteria P COG0226 ABC-type phosphate transport system, periplasmic component pstS - - ko:K02040 ko02010,ko02020,ko05152,map02010,map02020,map05152 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - PBP_like_2 k59_25613_1 394221.Mmar10_0351 3.91e-104 319.0 COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,1NBSJ@1224|Proteobacteria,2TU21@28211|Alphaproteobacteria,43Z43@69657|Hyphomonadaceae 28211|Alphaproteobacteria C pyruvate flavodoxin ferredoxin oxidoreductase MA20_01045 - 1.2.7.11,1.2.7.3 ko:K00174 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - PFOR_II,POR,POR_N k59_1607450_1 509190.Cseg_0855 1.05e-46 161.0 COG1171@1|root,COG1171@2|Bacteria,1MVWJ@1224|Proteobacteria,2TQN9@28211|Alphaproteobacteria,2KF7B@204458|Caulobacterales 204458|Caulobacterales E PFAM Pyridoxal-5'-phosphate-dependent protein beta subunit - - 4.3.1.19 ko:K01754 ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230 M00570 R00220,R00996 RC00418,RC02600 ko00000,ko00001,ko00002,ko01000 - - - PALP k59_1607450_2 998674.ATTE01000001_gene4417 6.38e-08 50.8 COG2154@1|root,COG2154@2|Bacteria,1RH99@1224|Proteobacteria,1S5YX@1236|Gammaproteobacteria,4614C@72273|Thiotrichales 72273|Thiotrichales H Pterin 4 alpha carbinolamine dehydratase - - 4.2.1.96 ko:K01724 ko00790,map00790 - R04734 RC01208 ko00000,ko00001,ko01000,ko04147 - - - Pterin_4a k59_1381687_1 288000.BBta_0640 1.92e-37 135.0 COG3751@1|root,COG3751@2|Bacteria,1RJST@1224|Proteobacteria,2UAC0@28211|Alphaproteobacteria,3K0EZ@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria O 2OG-Fe(II) oxygenase superfamily - - - - - - - - - - - - 2OG-FeII_Oxy_3 k59_645025_1 1122137.AQXF01000001_gene3163 1.25e-30 114.0 COG1968@1|root,COG1968@2|Bacteria,1MX02@1224|Proteobacteria,2TSUR@28211|Alphaproteobacteria 28211|Alphaproteobacteria V Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin uppP GO:0008150,GO:0042221,GO:0046677,GO:0050896 3.6.1.27 ko:K06153 ko00550,map00550 - R05627 RC00002 ko00000,ko00001,ko01000,ko01011 - - - BacA k59_645025_2 1122137.AQXF01000001_gene3162 7.68e-84 260.0 COG0493@1|root,COG0493@2|Bacteria,1MU2H@1224|Proteobacteria,2TSE2@28211|Alphaproteobacteria 28211|Alphaproteobacteria E glutamate synthase gltD - 1.4.1.13,1.4.1.14 ko:K00266 ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 - R00093,R00114,R00248 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - Fer4_20,Pyr_redox_2 k59_250689_2 1120956.JHZK01000004_gene1423 3.28e-125 375.0 COG0581@1|root,COG0581@2|Bacteria,1MUWB@1224|Proteobacteria,2TQYQ@28211|Alphaproteobacteria,1JNFA@119043|Rhodobiaceae 28211|Alphaproteobacteria P Domain of unknown function (DUF3333) pstA - - ko:K02038 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - BPD_transp_1,DUF3333 k59_419920_2 935548.KI912159_gene3804 8.22e-14 72.8 COG0031@1|root,COG0517@1|root,COG0031@2|Bacteria,COG0517@2|Bacteria,1MUBE@1224|Proteobacteria,2TT3E@28211|Alphaproteobacteria,43NW9@69277|Phyllobacteriaceae 28211|Alphaproteobacteria E Pyridoxal-phosphate dependent enzyme - - 4.2.1.22 ko:K01697 ko00260,ko00270,ko01100,ko01130,ko01230,map00260,map00270,map01100,map01130,map01230 M00035,M00338 R00891,R01290,R04942 RC00056,RC00069,RC00256,RC00489,RC01246 ko00000,ko00001,ko00002,ko01000 - - - CBS,PALP k59_1435732_1 713587.THITH_05065 4.94e-29 112.0 COG3222@1|root,COG3222@2|Bacteria,1RB1V@1224|Proteobacteria,1S971@1236|Gammaproteobacteria,1WYN8@135613|Chromatiales 135613|Chromatiales S Uncharacterized protein conserved in bacteria (DUF2064) - - - ko:K09931 - - - - ko00000 - - - DUF2064 k59_1435732_2 1166948.JPZL01000001_gene2849 1.49e-15 74.3 COG1215@1|root,COG1215@2|Bacteria,1RA75@1224|Proteobacteria,1S3RM@1236|Gammaproteobacteria,1XJSW@135619|Oceanospirillales 135619|Oceanospirillales M Glycosyl transferase family 2 - - - - - - - - - - - - Glycos_transf_2 k59_1043381_1 640081.Dsui_2703 5.19e-79 261.0 COG1196@1|root,COG1196@2|Bacteria,1MUAQ@1224|Proteobacteria,2VJMF@28216|Betaproteobacteria,2KV3S@206389|Rhodocyclales 206389|Rhodocyclales D Required for chromosome condensation and partitioning smc - - ko:K03529 - - - - ko00000,ko03036 - - - SMC_N,SMC_hinge k59_1607463_1 596154.Alide2_0477 7.72e-37 144.0 COG0457@1|root,COG3914@1|root,COG0457@2|Bacteria,COG3914@2|Bacteria,1MVMG@1224|Proteobacteria,2VH3M@28216|Betaproteobacteria,4ABFW@80864|Comamonadaceae 28216|Betaproteobacteria O SMART Tetratricopeptide - - - - - - - - - - - - Glyco_transf_41,TPR_1,TPR_11,TPR_16,TPR_19,TPR_2,TPR_8 k59_308434_1 316407.85674360 1.41e-172 488.0 COG0001@1|root,COG0001@2|Bacteria,1MUY5@1224|Proteobacteria,1RM7N@1236|Gammaproteobacteria,3XNJF@561|Escherichia 1236|Gammaproteobacteria H glutamate-1-semialdehyde 2,1-aminomutase activity hemL GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006725,GO:0006778,GO:0006779,GO:0006782,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016853,GO:0016866,GO:0016869,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042286,GO:0042440,GO:0042802,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046483,GO:0046501,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 5.4.3.8 ko:K01845 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R02272 RC00677 ko00000,ko00001,ko00002,ko01000,ko01007 - - iUMNK88_1353.UMNK88_158 Aminotran_3 k59_1662924_1 158500.BV97_00932 1.54e-87 273.0 COG4964@1|root,COG4964@2|Bacteria,1MV8G@1224|Proteobacteria,2TRNN@28211|Alphaproteobacteria,2K0ZQ@204457|Sphingomonadales 204457|Sphingomonadales U Belongs to the GSP D family cpaC - - ko:K02280 - - - - ko00000,ko02035,ko02044 - - - BON,Secretin,T2SS-T3SS_pil_N k59_1662924_2 702113.PP1Y_AT19175 1.44e-24 98.6 COG5461@1|root,COG5461@2|Bacteria,1REYP@1224|Proteobacteria,2U8J3@28211|Alphaproteobacteria,2K5AY@204457|Sphingomonadales 204457|Sphingomonadales N Pilus assembly protein CpaD cpaD - - ko:K02281 - - - - ko00000,ko02035,ko02044 - - - Pilus_CpaD k59_25633_1 1463856.JOHY01000007_gene770 4.63e-40 142.0 2F1HE@1|root,33UHX@2|Bacteria,2IH41@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - - k59_419927_1 314345.SPV1_03128 3.34e-69 234.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria 1224|Proteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family mdtC - - - - - - - - - - - ACR_tran k59_1211683_1 316407.85675878 1.21e-149 432.0 COG0531@1|root,COG0531@2|Bacteria,1MWXV@1224|Proteobacteria,1RPPM@1236|Gammaproteobacteria,3XQFH@561|Escherichia 1236|Gammaproteobacteria E transmembrane transporter activity ygjI GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - - - - - - - - - - AA_permease_2 k59_703231_2 926550.CLDAP_40800 1.72e-37 136.0 2CI52@1|root,2ZC5H@2|Bacteria,2G6K9@200795|Chloroflexi 200795|Chloroflexi - - - - - - - - - - - - - - - k59_1435736_1 756499.Desde_3218 3.52e-24 105.0 COG0606@1|root,COG1961@1|root,COG0606@2|Bacteria,COG1961@2|Bacteria,1TPUG@1239|Firmicutes,25B03@186801|Clostridia,261DM@186807|Peptococcaceae 186801|Clostridia L Resolvase, N terminal domain - - - ko:K06400 - - - - ko00000 - - - Recombinase,Resolvase,Zn_ribbon_recom k59_1435736_2 1167006.UWK_01630 1.99e-38 144.0 COG0758@1|root,COG0758@2|Bacteria,1MVF6@1224|Proteobacteria,42N10@68525|delta/epsilon subdivisions,2WJI9@28221|Deltaproteobacteria,2MHSD@213118|Desulfobacterales 28221|Deltaproteobacteria LU TIGRFAM DNA protecting protein DprA dprA - - ko:K04096 - - - - ko00000 - - - DNA_processg_A,HHH_5 k59_250706_1 318167.Sfri_3964 3.26e-62 209.0 COG4805@1|root,COG4805@2|Bacteria,1MUBX@1224|Proteobacteria,1RMT7@1236|Gammaproteobacteria,2Q919@267890|Shewanellaceae 1236|Gammaproteobacteria S Bacterial protein of unknown function (DUF885) - - - - - - - - - - - - DUF885 k59_757810_1 436308.Nmar_1128 7.43e-34 125.0 COG0803@1|root,arCOG01005@2157|Archaea,41T29@651137|Thaumarchaeota 651137|Thaumarchaeota P Periplasmic solute binding protein - - - ko:K09815 ko02010,map02010 M00242 - - ko00000,ko00001,ko00002,ko02000 3.A.1.15.3,3.A.1.15.5 - - ZnuA k59_82857_1 290397.Adeh_3398 8.92e-36 132.0 COG0545@1|root,COG0545@2|Bacteria,1RDA1@1224|Proteobacteria,42QU4@68525|delta/epsilon subdivisions,2WMRQ@28221|Deltaproteobacteria 28221|Deltaproteobacteria M peptidylprolyl isomerase, FKBP-type - - 5.2.1.8 ko:K01802,ko:K03772 - - - - ko00000,ko01000,ko03110 - - - FKBP_C,FKBP_N k59_419936_1 1122194.AUHU01000004_gene1507 1.37e-61 209.0 COG0665@1|root,COG4121@1|root,COG0665@2|Bacteria,COG4121@2|Bacteria,1MZW5@1224|Proteobacteria,1RMTE@1236|Gammaproteobacteria,464VK@72275|Alteromonadaceae 1236|Gammaproteobacteria H Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 mnmC GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0003824,GO:0004808,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016491,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0055114,GO:0071704,GO:0071949,GO:0090304,GO:0097159,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363 2.1.1.61 ko:K15461 - - R00601,R08702 RC00003,RC00053,RC00060,RC01483 ko00000,ko01000,ko03016 - - - DAO,Methyltransf_30 k59_1154363_1 61647.LG71_17430 2.18e-20 95.5 COG4772@1|root,COG4772@2|Bacteria,1MUIH@1224|Proteobacteria,1RQYX@1236|Gammaproteobacteria 1236|Gammaproteobacteria P receptor yncD - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_1097321_1 1096930.L284_05910 3.17e-17 78.2 COG0811@1|root,COG0811@2|Bacteria,1NCWW@1224|Proteobacteria,2TQXQ@28211|Alphaproteobacteria,2K039@204457|Sphingomonadales 204457|Sphingomonadales U MotA TolQ ExbB proton channel tolQ - - ko:K03562 ko01120,map01120 - - - ko00000,ko02000 1.A.30.2.2 - - MotA_ExbB k59_1097321_2 555793.WSK_2451 2.04e-57 182.0 COG0848@1|root,COG0848@2|Bacteria,1MZ6M@1224|Proteobacteria,2UA46@28211|Alphaproteobacteria,2K53V@204457|Sphingomonadales 204457|Sphingomonadales U Biopolymer transport protein tolR - - ko:K03560 - - - - ko00000,ko02000 1.A.30.2.2 - - ExbD k59_1043411_2 1335757.SPICUR_05065 4.64e-63 205.0 COG1420@1|root,COG1420@2|Bacteria,1MVX4@1224|Proteobacteria,1RR2F@1236|Gammaproteobacteria,1WXB7@135613|Chromatiales 135613|Chromatiales K Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons hrcA - - ko:K03705 - - - - ko00000,ko03000 - - - HrcA,HrcA_DNA-bdg k59_1774289_1 627192.SLG_16470 2.02e-56 186.0 2919Q@1|root,32TZW@2|Bacteria,1R3DM@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_82877_1 1122137.AQXF01000007_gene3622 1.29e-137 410.0 COG0376@1|root,COG0376@2|Bacteria,1MUBF@1224|Proteobacteria,2TQJ7@28211|Alphaproteobacteria 28211|Alphaproteobacteria P Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity katG - 1.11.1.21 ko:K03782 ko00360,ko00380,ko00940,ko00983,ko01100,ko01110,map00360,map00380,map00940,map00983,map01100,map01110 - R00602,R00698,R02596,R02670,R03919,R04007,R07443,R11906 RC00034,RC00213,RC00767,RC02141 ko00000,ko00001,ko01000 - - - peroxidase k59_365279_1 402881.Plav_2237 5.93e-38 140.0 COG0617@1|root,COG0617@2|Bacteria,1MVCS@1224|Proteobacteria,2TRPZ@28211|Alphaproteobacteria,1JNDK@119043|Rhodobiaceae 28211|Alphaproteobacteria J Probable RNA and SrmB- binding site of polymerase A pcnB - 2.7.7.19,2.7.7.72 ko:K00970,ko:K00974 ko03013,ko03018,map03013,map03018 - R09382,R09383,R09384,R09386 RC00078 ko00000,ko00001,ko01000,ko03016,ko03019 - - - PolyA_pol,PolyA_pol_RNAbd k59_1435762_1 232721.Ajs_2370 6.78e-06 48.9 COG0581@1|root,COG0581@2|Bacteria,1MUWB@1224|Proteobacteria,2VH6Y@28216|Betaproteobacteria,4ABXP@80864|Comamonadaceae 28216|Betaproteobacteria P TIGRFAM phosphate ABC transporter, inner membrane subunit PstA pstA - - ko:K02038 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - BPD_transp_1 k59_1097332_1 1121405.dsmv_3439 3.47e-25 106.0 COG1089@1|root,COG1089@2|Bacteria,1MUX0@1224|Proteobacteria,42KZY@68525|delta/epsilon subdivisions,2WJ4B@28221|Deltaproteobacteria,2MJ21@213118|Desulfobacterales 28221|Deltaproteobacteria M Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose gmd - 4.2.1.47 ko:K01711 ko00051,ko00520,ko01100,map00051,map00520,map01100 - R00888 RC00402 ko00000,ko00001,ko01000 - - - GDP_Man_Dehyd k59_1211723_1 197221.22295879 3.31e-54 182.0 COG0117@1|root,COG1985@1|root,COG0117@2|Bacteria,COG1985@2|Bacteria,1G0NF@1117|Cyanobacteria 1117|Cyanobacteria H Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate ribD GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0016070,GO:0034641,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360 1.1.1.193,3.5.4.26 ko:K11752 ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024 M00125 R03458,R03459 RC00204,RC00933 ko00000,ko00001,ko00002,ko01000 - - - RibD_C,dCMP_cyt_deam_1 k59_589994_1 765914.ThisiDRAFT_2349 8.65e-40 140.0 COG0704@1|root,COG0704@2|Bacteria,1MUMI@1224|Proteobacteria,1RMW5@1236|Gammaproteobacteria,1WXKZ@135613|Chromatiales 135613|Chromatiales P Plays a role in the regulation of phosphate uptake - - - ko:K02039 - - - - ko00000 - - - PhoU k59_1435768_1 1229909.NSED_03350 1.27e-74 230.0 COG0388@1|root,arCOG00062@2157|Archaea 2157|Archaea H Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase - - 3.5.1.3 ko:K13566 ko00250,map00250 - R00269,R00348 RC00010 ko00000,ko00001,ko01000 - - - CN_hydrolase k59_531051_1 1121912.AUHD01000008_gene189 8.58e-58 195.0 COG0008@1|root,COG0008@2|Bacteria,4NFCC@976|Bacteroidetes,1HXAH@117743|Flavobacteriia 976|Bacteroidetes J Catalyzes a two-step reaction, first charging a glutamine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA glnS - 6.1.1.18 ko:K01886 ko00970,ko01100,map00970,map01100 M00359,M00360 R03652 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_1c,tRNA-synt_1c_C k59_531051_2 313598.MED152_10355 4.96e-38 128.0 COG3478@1|root,COG3478@2|Bacteria,4NWGJ@976|Bacteroidetes,1I51N@117743|Flavobacteriia,3VWSS@52959|Polaribacter 976|Bacteroidetes S Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082) - - - ko:K07069 - - - - ko00000 - - - zinc_ribbon_13 k59_1774301_1 1122137.AQXF01000002_gene180 5.61e-132 387.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2TQPG@28211|Alphaproteobacteria 28211|Alphaproteobacteria T COG2204 Response regulator containing CheY-like receiver AAA-type ATPase and DNA-binding domains ntrC - - ko:K07712 ko02020,map02020 M00497 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activ_2,Sigma54_activat k59_814580_2 158500.BV97_02118 5.73e-28 108.0 COG1475@1|root,COG1475@2|Bacteria,1MW2E@1224|Proteobacteria,2TSTN@28211|Alphaproteobacteria,2K0RQ@204457|Sphingomonadales 204457|Sphingomonadales K Belongs to the ParB family parB - - ko:K03497 - - - - ko00000,ko03000,ko03036,ko04812 - - - ParBc k59_1097353_1 471852.Tcur_1518 4.76e-66 227.0 COG0145@1|root,COG0146@1|root,COG0145@2|Bacteria,COG0146@2|Bacteria,2GIYE@201174|Actinobacteria,4EMF2@85012|Streptosporangiales 201174|Actinobacteria EQ Hydantoinase B/oxoprolinase oplA - 3.5.2.9 ko:K01469 ko00480,map00480 - R00251 RC00553 ko00000,ko00001,ko01000 - - iNJ661.Rv0266c Hydant_A_N,Hydantoinase_A,Hydantoinase_B k59_365314_1 1122137.AQXF01000007_gene3562 1.23e-161 478.0 COG0058@1|root,COG0058@2|Bacteria,1MW4J@1224|Proteobacteria,2TRER@28211|Alphaproteobacteria 28211|Alphaproteobacteria G Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties glgP GO:0000272,GO:0003674,GO:0003824,GO:0004645,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0005976,GO:0005977,GO:0005980,GO:0006073,GO:0006091,GO:0006112,GO:0008144,GO:0008150,GO:0008152,GO:0008184,GO:0009056,GO:0009057,GO:0009251,GO:0009987,GO:0015980,GO:0016052,GO:0016740,GO:0016757,GO:0016758,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044247,GO:0044248,GO:0044260,GO:0044262,GO:0044264,GO:0044275,GO:0044424,GO:0044464,GO:0048037,GO:0050662,GO:0055114,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901575 2.4.1.1 ko:K00688 ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931 - R02111 - ko00000,ko00001,ko01000 - GT35 - Phosphorylase k59_1551501_1 2340.JV46_07180 2.59e-19 82.8 COG0200@1|root,COG0200@2|Bacteria,1RDC8@1224|Proteobacteria,1S3P6@1236|Gammaproteobacteria,1J6F0@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J binds to the 23S rRNA rplO GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02876 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L27A k59_1551501_2 90813.JQMT01000001_gene232 3.05e-26 97.4 COG1841@1|root,COG1841@2|Bacteria,1N6ZE@1224|Proteobacteria,1SC8N@1236|Gammaproteobacteria,4617P@72273|Thiotrichales 72273|Thiotrichales J Ribosomal protein L30 rpmD - - ko:K02907 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L30 k59_1551501_3 1033802.SSPSH_003087 3.19e-30 111.0 COG0098@1|root,COG0098@2|Bacteria,1MUS4@1224|Proteobacteria,1RNEV@1236|Gammaproteobacteria 1236|Gammaproteobacteria J Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body rpsE GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990145,GO:1990904 - ko:K02988 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S5,Ribosomal_S5_C k59_419982_1 1537715.JQFJ01000002_gene1249 1.84e-08 60.8 COG4782@1|root,COG4782@2|Bacteria,1MVAD@1224|Proteobacteria,2TTCR@28211|Alphaproteobacteria,2K84S@204457|Sphingomonadales 204457|Sphingomonadales S Alpha/beta hydrolase of unknown function (DUF900) - - - - - - - - - - - - DUF900 k59_1154410_1 393595.ABO_1273 1.44e-92 285.0 COG0015@1|root,COG0015@2|Bacteria,1MV4B@1224|Proteobacteria,1RN93@1236|Gammaproteobacteria,1XHPF@135619|Oceanospirillales 135619|Oceanospirillales F Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily purB - 4.3.2.2 ko:K01756 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048,M00049 R01083,R04559 RC00379,RC00444,RC00445 ko00000,ko00001,ko00002,ko01000 - - - ASL_C,Lyase_1 k59_1266150_1 1144305.PMI02_01075 8.07e-49 167.0 COG1414@1|root,COG1414@2|Bacteria 2|Bacteria K Transcriptional regulator - - - ko:K07075,ko:K10439 ko02010,ko02030,map02010,map02030 M00212 - - ko00000,ko00001,ko00002,ko02000 3.A.1.2.1,3.A.1.2.13,3.A.1.2.19 - - Flavin_Reduct,HTH_IclR,IclR,NB-ARC,TIR_2,TPR_12 k59_25734_1 1123279.ATUS01000001_gene952 5e-165 474.0 COG0065@1|root,COG0065@2|Bacteria,1MVYR@1224|Proteobacteria,1RMF6@1236|Gammaproteobacteria,1J51D@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate leuC - 4.2.1.33,4.2.1.35 ko:K01703 ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230 M00432,M00535 R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170 RC00497,RC00976,RC00977,RC01041,RC01046,RC03072 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase k59_1324308_2 1144319.PMI16_05039 3.67e-05 48.5 COG1167@1|root,COG1167@2|Bacteria,1MVGT@1224|Proteobacteria,2VHEY@28216|Betaproteobacteria,472NY@75682|Oxalobacteraceae 28216|Betaproteobacteria K helix_turn_helix gluconate operon transcriptional repressor - - - ko:K00375 - - - - ko00000,ko03000 - - - Aminotran_1_2,GntR k59_1553018_1 330214.NIDE2119 2.35e-57 198.0 COG2172@1|root,COG2199@1|root,COG2208@1|root,COG2172@2|Bacteria,COG2208@2|Bacteria,COG3706@2|Bacteria 2|Bacteria T GGDEF domain rsbU - 3.1.3.3,4.6.1.1 ko:K01768,ko:K07315,ko:K20977 ko00230,ko02020,ko02025,ko04113,ko04213,map00230,map02020,map02025,map04113,map04213 M00695,M00820 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000,ko02022,ko03021 - - - HATPase_c_2,PAS_9,Response_reg,SpoIIE k59_139833_1 436308.Nmar_1203 9.43e-78 241.0 arCOG10580@1|root,arCOG10580@2157|Archaea 436308.Nmar_1203|- - - - - - - - - - - - - - - - k59_1436745_1 1122137.AQXF01000003_gene2252 6.86e-84 264.0 COG2199@1|root,COG3706@2|Bacteria,1MZV7@1224|Proteobacteria,2TRAF@28211|Alphaproteobacteria 28211|Alphaproteobacteria T GGDEF domain MA20_36965 - - - - - - - - - - - GGDEF k59_591391_1 1121875.KB907550_gene636 6.37e-103 315.0 COG2015@1|root,COG2015@2|Bacteria,4NJE2@976|Bacteroidetes 976|Bacteroidetes Q Alkyl sulfatase dimerisation - - - - - - - - - - - - Alkyl_sulf_C,Alkyl_sulf_dimr,Lactamase_B k59_139840_1 237368.SCABRO_02452 0.000223 46.2 COG0589@1|root,COG0589@2|Bacteria,2J0XB@203682|Planctomycetes 203682|Planctomycetes T Universal stress protein - - - - - - - - - - - - Usp k59_27198_1 1234593.ANBY01000030_gene1211 4.26e-10 63.5 COG3942@1|root,COG3942@2|Bacteria,1V9RV@1239|Firmicutes,4HJW5@91061|Bacilli,4GZDF@90964|Staphylococcaceae 91061|Bacilli S CHAP domain - - - - - - - - - - - - CHAP k59_991972_2 926550.CLDAP_15240 2.65e-65 212.0 COG0448@1|root,COG0448@2|Bacteria,2G7W8@200795|Chloroflexi 200795|Chloroflexi H PFAM transferase hexapeptide repeat containing protein - - 2.7.7.27 ko:K00975 ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026 M00565 R00948 RC00002 ko00000,ko00001,ko00002,ko01000 - - - Hexapep,NTP_transferase k59_1781902_1 717785.HYPMC_0850 7.14e-93 281.0 COG1858@1|root,COG1858@2|Bacteria,1MV70@1224|Proteobacteria,2TRTJ@28211|Alphaproteobacteria,3N7Y0@45401|Hyphomicrobiaceae 28211|Alphaproteobacteria C Di-haem cytochrome c peroxidase ccpA - 1.11.1.5 ko:K00428 - - - - ko00000,ko01000 - - - CCP_MauG,Cytochrom_C k59_483982_1 1123279.ATUS01000004_gene3036 3.99e-11 69.3 COG0747@1|root,COG0747@2|Bacteria,1P1HT@1224|Proteobacteria,1RPYQ@1236|Gammaproteobacteria,1JBY2@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Bacterial extracellular solute-binding proteins, family 5 Middle - - - ko:K02035 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - SBP_bac_5 k59_715265_2 1173028.ANKO01000170_gene3354 3.84e-33 133.0 COG0642@1|root,COG0784@1|root,COG2202@1|root,COG0784@2|Bacteria,COG2202@2|Bacteria,COG2205@2|Bacteria,1G09B@1117|Cyanobacteria,1H8C9@1150|Oscillatoriales 1117|Cyanobacteria T Signal transduction histidine kinase, subgroup 1, dimerisation phosphoacceptor domain - - - - - - - - - - - - GAF,GAF_2,HATPase_c,HisKA,PAS,PAS_4,Response_reg k59_991973_1 290397.Adeh_1279 1.45e-50 181.0 COG0322@1|root,COG0322@2|Bacteria,1MV38@1224|Proteobacteria,42MB1@68525|delta/epsilon subdivisions,2WJ76@28221|Deltaproteobacteria,2YUHH@29|Myxococcales 28221|Deltaproteobacteria L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision uvrC GO:0005575,GO:0005622,GO:0005623,GO:0006950,GO:0006974,GO:0008150,GO:0009380,GO:0009987,GO:0032991,GO:0033554,GO:0044424,GO:0044464,GO:0050896,GO:0051716,GO:1902494,GO:1905347,GO:1905348,GO:1990391 - ko:K03703 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - GIY-YIG,HHH_2,HHH_5,UVR,UvrC_HhH_N k59_377208_1 316407.85676514 5.15e-104 329.0 COG0457@1|root,COG3118@1|root,COG0457@2|Bacteria,COG3118@2|Bacteria,1MVB8@1224|Proteobacteria,1RPSN@1236|Gammaproteobacteria,3XMYE@561|Escherichia 1236|Gammaproteobacteria O cellulose synthase operon protein C bcsC - - ko:K20543 - - - - ko00000,ko02000 1.B.55.3 - - BCSC_C,TPR_16,TPR_19,TPR_8 k59_602297_1 252305.OB2597_09014 2.68e-14 76.3 COG1737@1|root,COG1737@2|Bacteria,1N3YS@1224|Proteobacteria,2TTJD@28211|Alphaproteobacteria,2PE25@252301|Oceanicola 28211|Alphaproteobacteria K Helix-turn-helix domain, rpiR family - - - - - - - - - - - - HTH_6,SIS k59_204995_1 1382303.JPOM01000001_gene1948 7.83e-95 283.0 COG0745@1|root,COG0745@2|Bacteria,1MU67@1224|Proteobacteria,2TRTZ@28211|Alphaproteobacteria,2KHTD@204458|Caulobacterales 204458|Caulobacterales T Transcriptional regulatory protein, C terminal - - - - - - - - - - - - Response_reg,Trans_reg_C k59_37735_1 1122137.AQXF01000001_gene3185 6.38e-107 335.0 COG0249@1|root,COG0249@2|Bacteria,1MUGX@1224|Proteobacteria,2TQRR@28211|Alphaproteobacteria 28211|Alphaproteobacteria L that it carries out the mismatch recognition step. This protein has a weak ATPase activity mutS GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - ko:K03555 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V k59_1053772_1 1229909.NSED_02660 4.31e-102 300.0 arCOG08739@1|root,arCOG08739@2157|Archaea,41SN6@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1053772_2 436308.Nmar_0529 2.93e-34 119.0 COG0231@1|root,arCOG04277@2157|Archaea,41SNP@651137|Thaumarchaeota 651137|Thaumarchaeota J Functions by promoting the formation of the first peptide bond eif5a - - ko:K03263 - - - - ko00000,ko03012 - - - eIF-5a k59_1781916_1 1415778.JQMM01000001_gene2014 7.06e-91 283.0 COG0539@1|root,COG0539@2|Bacteria,1MVAV@1224|Proteobacteria,1RMFY@1236|Gammaproteobacteria,1J51F@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence rpsA GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006417,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015935,GO:0016043,GO:0017148,GO:0019222,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065003,GO:0065007,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0080090,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904,GO:2000112,GO:2000113,GO:2000765,GO:2000766 - ko:K02945 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - S1 k59_766452_1 234267.Acid_7660 5.51e-38 138.0 COG0167@1|root,COG1149@1|root,COG0167@2|Bacteria,COG1149@2|Bacteria,3Y3D8@57723|Acidobacteria 57723|Acidobacteria C TIGRFAM Dihydroorotate dehydrogenase - - 1.3.1.1 ko:K17723 ko00240,ko00410,ko00770,ko01100,map00240,map00410,map00770,map01100 M00046 R00977,R01414,R11026 RC00072,RC00123 ko00000,ko00001,ko00002,ko01000 - - - DHO_dh,Fer4_21 k59_766452_2 215803.DB30_5626 6.39e-23 100.0 COG0493@1|root,COG0493@2|Bacteria,1MU2H@1224|Proteobacteria,42MGY@68525|delta/epsilon subdivisions,2WJHC@28221|Deltaproteobacteria,2YUCU@29|Myxococcales 28221|Deltaproteobacteria E Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster - - 1.3.1.1 ko:K17722 ko00240,ko00410,ko00770,ko01100,map00240,map00410,map00770,map01100 M00046 R00977,R01414,R11026 RC00072,RC00123 ko00000,ko00001,ko00002,ko01000 - - - Fer4_20,Pyr_redox_2 k59_1506926_1 511145.b3746 9.3e-166 474.0 COG0714@1|root,COG0714@2|Bacteria,1PC08@1224|Proteobacteria,1RQ5U@1236|Gammaproteobacteria,3XMMQ@561|Escherichia 1236|Gammaproteobacteria S Functions as an ATPase. May play a role in metal insertion (metal-chelatase) or as a chaperone ravA GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0042802,GO:0044424,GO:0044444,GO:0044464 - ko:K03924 - - - - ko00000,ko01000 - - - AAA_5,DUF3763 k59_539080_1 644107.SL1157_2652 1.46e-24 105.0 COG1028@1|root,COG1028@2|Bacteria,1MWJI@1224|Proteobacteria,2TRNJ@28211|Alphaproteobacteria,4NATX@97050|Ruegeria 28211|Alphaproteobacteria IQ dehydrogenase reductase MA20_19195 - 1.1.1.100 ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 k59_428584_1 1221522.B723_29835 1.61e-15 77.8 COG3038@1|root,COG3038@2|Bacteria,1MZ7X@1224|Proteobacteria,1S3RF@1236|Gammaproteobacteria,1YPC4@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria C Cytochrome B561 yceJ GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K12262 - - - - ko00000 - - - Ni_hydr_CYTB k59_428584_2 1118054.CAGW01000060_gene2575 5e-11 62.0 COG0778@1|root,COG0778@2|Bacteria,1V6YR@1239|Firmicutes,4HIM7@91061|Bacilli,27696@186822|Paenibacillaceae 91061|Bacilli C Nitroreductase family - - - - - - - - - - - - Nitroreductase k59_93387_1 357808.RoseRS_0905 2.12e-20 98.2 COG0419@1|root,COG0419@2|Bacteria,2G682@200795|Chloroflexi,375BN@32061|Chloroflexia 32061|Chloroflexia L PFAM SMC domain protein - - - ko:K03546 - - - - ko00000,ko03400 - - - AAA_23,Rad50_zn_hook,SbcCD_C k59_766472_2 1122194.AUHU01000003_gene2183 4.84e-65 211.0 COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,1RNAM@1236|Gammaproteobacteria,4658T@72275|Alteromonadaceae 1236|Gammaproteobacteria G COG1593 TRAP-type C4-dicarboxylate transport system, large permease component - - - - - - - - - - - - DctM k59_320914_1 998674.ATTE01000001_gene473 7.09e-72 226.0 COG0472@1|root,COG0472@2|Bacteria,1MUTK@1224|Proteobacteria,1RNIG@1236|Gammaproteobacteria,4604R@72273|Thiotrichales 72273|Thiotrichales M First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan mraY - 2.7.8.13 ko:K01000 ko00550,ko01100,ko01502,map00550,map01100,map01502 - R05629,R05630 RC00002,RC02753 ko00000,ko00001,ko01000,ko01011 9.B.146 - - Glycos_transf_4,MraY_sig1 k59_320914_2 765914.ThisiDRAFT_2385 1e-55 191.0 COG0771@1|root,COG0771@2|Bacteria,1MVYD@1224|Proteobacteria,1RP25@1236|Gammaproteobacteria,1WWI1@135613|Chromatiales 135613|Chromatiales M Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) murD - 6.3.2.9 ko:K01925 ko00471,ko00550,ko01100,map00471,map00550,map01100 - R02783 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase_C,Mur_ligase_M k59_539084_1 1229909.NSED_02485 2.5e-113 337.0 COG0719@1|root,arCOG01715@2157|Archaea,41S7W@651137|Thaumarchaeota 651137|Thaumarchaeota O FeS assembly protein SufD - - - ko:K09014,ko:K09015 - - - - ko00000 - - - UPF0051 k59_428589_1 498761.HM1_1380 1.08e-17 78.2 COG0089@1|root,COG0089@2|Bacteria,1VA4W@1239|Firmicutes,24MN8@186801|Clostridia 186801|Clostridia J One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome rplW - - ko:K02892 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L23 k59_428589_2 278957.ABEA03000071_gene3042 3.53e-30 114.0 COG0090@1|root,COG0090@2|Bacteria,46S71@74201|Verrucomicrobia,3K7DN@414999|Opitutae 414999|Opitutae J One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity rplB - - ko:K02886 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L2,Ribosomal_L2_C k59_766478_1 1121937.AUHJ01000003_gene3186 1.05e-63 219.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,464FM@72275|Alteromonadaceae 1236|Gammaproteobacteria T Putative diguanylate phosphodiesterase dosP - - - - - - - - - - - EAL,GAF_2,GGDEF,PAS_3,PAS_4,PAS_9,Phosphonate-bd k59_1781946_1 1096546.WYO_0164 6.67e-26 110.0 COG0749@1|root,COG0749@2|Bacteria,1MWX7@1224|Proteobacteria 1224|Proteobacteria L COG0749 DNA polymerase I - 3'-5' exonuclease and polymerase domains - - 2.7.7.7 ko:K02334 - - - - ko00000,ko01000 - - - DNA_pol_A,DNA_pol_A_exo1 k59_320921_1 944481.JAFP01000001_gene99 1.09e-10 62.0 COG0156@1|root,COG0156@2|Bacteria,1MVVH@1224|Proteobacteria,42MM1@68525|delta/epsilon subdivisions,2WIU7@28221|Deltaproteobacteria,2M6TU@213113|Desulfurellales 28221|Deltaproteobacteria E Cys/Met metabolism PLP-dependent enzyme bioF1 - 2.3.1.29 ko:K00639 ko00260,map00260 - R00371 RC00004,RC00394 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_1_2 k59_320921_2 44060.JODL01000012_gene3576 1.72e-41 149.0 COG0454@1|root,COG0456@2|Bacteria,2GNAV@201174|Actinobacteria 201174|Actinobacteria K acetyltransferase - - - - - - - - - - - - Acetyltransf_1 k59_1729896_1 1110502.TMO_3109 1.67e-67 215.0 COG0491@1|root,COG0491@2|Bacteria,1MVC3@1224|Proteobacteria,2TUAZ@28211|Alphaproteobacteria,2JWCT@204441|Rhodospirillales 204441|Rhodospirillales S Metallo-beta-lactamase superfamily - - - - - - - - - - - - Lactamase_B k59_1617326_1 502025.Hoch_6208 1.81e-05 53.5 COG0515@1|root,COG0642@1|root,COG0784@1|root,COG2203@1|root,COG3899@1|root,COG0515@2|Bacteria,COG0784@2|Bacteria,COG2203@2|Bacteria,COG2205@2|Bacteria,COG3899@2|Bacteria,1NRP8@1224|Proteobacteria,42M0Y@68525|delta/epsilon subdivisions,2X7MY@28221|Deltaproteobacteria,2YXD9@29|Myxococcales 28221|Deltaproteobacteria T Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - - - - - - - - - - AAA_16,GAF,GAF_2,HAMP,HATPase_c,HisKA,Pkinase,Response_reg k59_1053821_1 1122137.AQXF01000001_gene2540 1.64e-104 315.0 COG3756@1|root,COG3756@2|Bacteria,1NGB2@1224|Proteobacteria,2VGAH@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Protein of unknown function (DUF1376) - - - - - - - - - - - - DUF1376 k59_484045_1 1123279.ATUS01000001_gene805 5.37e-16 84.3 COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,1S1M2@1236|Gammaproteobacteria,1J5J5@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Acyl-CoA dehydrogenase, C-terminal domain - - 1.3.8.12 ko:K14448 ko00630,ko01120,ko01200,map00630,map01120,map01200 M00373 R09293 RC02483 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_1564332_2 1116472.MGMO_103c00050 2.16e-47 155.0 COG0454@1|root,COG0456@2|Bacteria,1RK3S@1224|Proteobacteria 1224|Proteobacteria K Acetyltransferase (GNAT) domain phnO - - - - - - - - - - - Acetyltransf_1 k59_1444905_1 316407.1742760 1.01e-115 358.0 COG0247@1|root,COG0277@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,1RQX2@1236|Gammaproteobacteria,3XM9Z@561|Escherichia 1236|Gammaproteobacteria C flavin adenine dinucleotide binding ydiJ GO:0000166,GO:0003674,GO:0005488,GO:0036094,GO:0043167,GO:0043168,GO:0048037,GO:0050660,GO:0050662,GO:0051536,GO:0051539,GO:0051540,GO:0097159,GO:1901265,GO:1901363 - - - - - - - - - - FAD-oxidase_C,FAD_binding_4,Fer4_8 k59_377269_1 391625.PPSIR1_40460 9.13e-114 330.0 COG0225@1|root,COG0225@2|Bacteria,1MVUS@1224|Proteobacteria,43BC6@68525|delta/epsilon subdivisions,2X255@28221|Deltaproteobacteria,2YY92@29|Myxococcales 28221|Deltaproteobacteria C Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine - - 1.8.4.11 ko:K07304 - - - - ko00000,ko01000 - - - PMSR k59_377269_2 595460.RRSWK_03194 9.49e-21 91.3 COG2239@1|root,COG2239@2|Bacteria,2IYCZ@203682|Planctomycetes 203682|Planctomycetes P Acts as a magnesium transporter - - - ko:K06213 - - - - ko00000,ko02000 1.A.26.1 - - CBS,MgtE,MgtE_N k59_1617333_1 436308.Nmar_1191 2.12e-102 315.0 COG1331@1|root,arCOG02007@2157|Archaea,41SHZ@651137|Thaumarchaeota 651137|Thaumarchaeota O Protein of unknown function, DUF255 - - - ko:K06888 - - - - ko00000 - - - Thioredox_DsbH k59_37763_1 1229909.NSED_03335 6.17e-62 197.0 COG1938@1|root,arCOG00347@2157|Archaea,41T2Y@651137|Thaumarchaeota 651137|Thaumarchaeota S PAC2 family - - - ko:K06869 - - - - ko00000 - - - PAC2 k59_37769_1 557599.MKAN_07990 1.04e-76 243.0 COG2072@1|root,COG2072@2|Bacteria,2GJEA@201174|Actinobacteria,23361@1762|Mycobacteriaceae 201174|Actinobacteria P flavoprotein involved in K transport - GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 - - - - - - - - - - FMO-like,K_oxygenase,Pyr_redox_3 k59_654215_1 555793.WSK_0821 4.64e-107 316.0 COG0726@1|root,COG0726@2|Bacteria,1MV3V@1224|Proteobacteria,2U6JZ@28211|Alphaproteobacteria,2K15F@204457|Sphingomonadales 204457|Sphingomonadales G Polysaccharide deacetylase - - - - - - - - - - - - Polysacc_deac_1 k59_654215_2 1357272.AVEO02000199_gene156 5.36e-25 102.0 COG0604@1|root,COG0604@2|Bacteria,1R5T6@1224|Proteobacteria,1SKZ0@1236|Gammaproteobacteria,1Z9RJ@136849|Pseudomonas syringae group 1236|Gammaproteobacteria C Zinc-binding dehydrogenase - - - - - - - - - - - - ADH_N,ADH_zinc_N k59_602397_1 999541.bgla_2g03040 5.7e-162 473.0 COG1071@1|root,COG1071@2|Bacteria,1MU5R@1224|Proteobacteria,2VNZH@28216|Betaproteobacteria,1K12G@119060|Burkholderiaceae 28216|Betaproteobacteria C e1 component (alpha subunit) bkdA1 - 1.2.4.4 ko:K00166 ko00280,ko00640,ko01100,ko01110,ko01130,map00280,map00640,map01100,map01110,map01130 M00036 R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997 RC00027,RC00627,RC02743,RC02883,RC02949,RC02953 br01601,ko00000,ko00001,ko00002,ko01000 - - - E1_dh,OxoDH_E1alpha_N k59_484071_1 1122137.AQXF01000002_gene506 3.42e-173 498.0 COG1960@1|root,COG1960@2|Bacteria,1MU20@1224|Proteobacteria,2TQJS@28211|Alphaproteobacteria 28211|Alphaproteobacteria I acyl-CoA dehydrogenase mmgC GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016627,GO:0036094,GO:0043167,GO:0043168,GO:0048037,GO:0050660,GO:0050662,GO:0052890,GO:0055114,GO:0097159,GO:1901265,GO:1901363 1.3.8.1,1.3.8.7 ko:K00248,ko:K00249,ko:K20035 ko00071,ko00280,ko00410,ko00640,ko00650,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map00650,map00920,map01100,map01110,map01120,map01130,map01200,map01212,map03320 M00013,M00036,M00087 R00924,R01175,R01178,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754,R11130 RC00052,RC00068,RC00076,RC00095,RC00120,RC00148,RC00246,RC03363 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_C,Acyl-CoA_dh_M,Acyl-CoA_dh_N,AcylCoA_DH_N k59_1729932_1 1003200.AXXA_13329 2.86e-24 106.0 COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,2VISZ@28216|Betaproteobacteria,3T2WZ@506|Alcaligenaceae 28216|Betaproteobacteria MU COG1538 Outer membrane protein oprM_1 - - - - - - - - - - - OEP k59_205094_1 279238.Saro_1730 1.48e-171 493.0 COG2272@1|root,COG2272@2|Bacteria,1MVQZ@1224|Proteobacteria,2TUA9@28211|Alphaproteobacteria,2K1A5@204457|Sphingomonadales 204457|Sphingomonadales I Belongs to the type-B carboxylesterase lipase family - - - ko:K03929 - - - - ko00000,ko01000 - CE10 - COesterase k59_539121_1 452637.Oter_4173 1.92e-78 244.0 COG2020@1|root,COG2020@2|Bacteria 2|Bacteria O methyltransferase activity - - 2.1.1.334 ko:K21310 ko00920,map00920 - R11546 RC02653 ko00000,ko00001,ko01000 - - - NnrU,PEMT k59_715398_1 29540.C481_13859 0.00032 48.5 COG0642@1|root,COG3413@1|root,arCOG02348@1|root,arCOG02278@2157|Archaea,arCOG02348@2157|Archaea,arCOG02358@2157|Archaea,2Y7KZ@28890|Euryarchaeota,240U3@183963|Halobacteria 183963|Halobacteria T GAF domain - - - - - - - - - - - - GAF_2,HATPase_c,HisKA k59_1671890_1 682795.AciX8_1195 9.61e-78 248.0 COG0606@1|root,COG0606@2|Bacteria,3Y3JA@57723|Acidobacteria,2JI3F@204432|Acidobacteriia 204432|Acidobacteriia O PFAM Magnesium chelatase, ChlI subunit - - - ko:K07391 - - - - ko00000 - - - ChlI,Mg_chelatase,Mg_chelatase_C k59_715405_1 1007105.PT7_3003 7.67e-60 196.0 COG4266@1|root,COG4266@2|Bacteria,1MXJK@1224|Proteobacteria,2VKRI@28216|Betaproteobacteria,3T765@506|Alcaligenaceae 28216|Betaproteobacteria F Allantoicase repeat alc - 3.5.3.4 ko:K01477 ko00230,ko01100,ko01120,map00230,map01100,map01120 M00546 R02422 RC00379,RC00712 ko00000,ko00001,ko00002,ko01000 - - - Allantoicase k59_1331905_2 1248916.ANFY01000007_gene2332 2.39e-48 165.0 COG1024@1|root,COG1024@2|Bacteria,1MVQN@1224|Proteobacteria,2U31Y@28211|Alphaproteobacteria,2K5DX@204457|Sphingomonadales 204457|Sphingomonadales I Enoyl-CoA hydratase/isomerase - - 5.3.3.18 ko:K15866 ko00360,ko01120,map00360,map01120 - R09837,R09839 RC00004,RC00326,RC02689,RC03003 ko00000,ko00001,ko01000 - - - ECH_1 k59_1221836_1 1498011.A0A096XUY1_9CAUD 1.74e-17 82.8 4QHBE@10239|Viruses,4QT2W@28883|Caudovirales 28883|Caudovirales - - - - - - - - - - - - - - - k59_484123_1 158500.BV97_02196 3.1e-85 257.0 COG0692@1|root,COG0692@2|Bacteria,1MV80@1224|Proteobacteria,2U1VI@28211|Alphaproteobacteria,2K0CQ@204457|Sphingomonadales 204457|Sphingomonadales L Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine ung - 3.2.2.27 ko:K03648 ko03410,ko05340,map03410,map05340 - - - ko00000,ko00001,ko01000,ko03400 - - - UDG k59_1106396_2 552531.BIF_01199 7.81e-07 55.5 COG4770@1|root,COG4770@2|Bacteria,2GIZP@201174|Actinobacteria,4CYU4@85004|Bifidobacteriales 201174|Actinobacteria I Carbamoyl-phosphate synthase L chain, ATP binding domain protein accC - 6.3.4.14,6.4.1.2,6.4.1.3 ko:K11263 ko00061,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00741 R00742,R01859,R04385 RC00040,RC00097,RC00253,RC00367,RC00609 ko00000,ko00001,ko00002,ko01000 - - - Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2 k59_1782992_1 661478.OP10G_1361 1.09e-36 135.0 COG1011@1|root,COG1011@2|Bacteria 2|Bacteria S phosphatase activity MA20_37750 - 3.1.3.10 ko:K07025,ko:K20866 ko00010,ko01120,map00010,map01120 - R00947 RC00078 ko00000,ko00001,ko01000 - - - HAD_2 k59_993192_1 421531.IX38_22565 3.07e-07 55.5 COG1028@1|root,COG1028@2|Bacteria,4NGQY@976|Bacteroidetes,1HZ7N@117743|Flavobacteriia,3ZPXU@59732|Chryseobacterium 976|Bacteroidetes IQ Enoyl-(Acyl carrier protein) reductase - - 1.1.1.401 ko:K21883 ko00051,ko01120,map00051,map01120 - R11339 RC00089 ko00000,ko00001,ko01000 - - - adh_short_C2 k59_767602_1 391603.FBALC1_07093 3.38e-92 292.0 COG2120@1|root,COG2120@2|Bacteria,4NE9K@976|Bacteroidetes,1HX7T@117743|Flavobacteriia 976|Bacteroidetes G LmbE family - - - - - - - - - - - - PIG-L k59_94542_1 935840.JAEQ01000015_gene3784 2.92e-47 166.0 COG0044@1|root,COG0044@2|Bacteria,1MVXY@1224|Proteobacteria,2TSTM@28211|Alphaproteobacteria,43GYU@69277|Phyllobacteriaceae 28211|Alphaproteobacteria F Catalyzes the reversible hydrolysis of the amide bond within dihydroorotate. This metabolic intermediate is required for the biosynthesis of pyrimidine nucleotides pyrC - 3.5.2.3 ko:K01465 ko00240,ko01100,map00240,map01100 M00051 R01993 RC00632 ko00000,ko00001,ko00002,ko01000 - - - Amidohydro_1 k59_94555_1 75379.Tint_3136 7.38e-06 47.8 2EP1T@1|root,33GNN@2|Bacteria,1NJTG@1224|Proteobacteria,2VYI0@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_94555_2 1331060.RLDS_01755 9.73e-40 136.0 COG3686@1|root,COG3686@2|Bacteria,1RAEH@1224|Proteobacteria,2U5JJ@28211|Alphaproteobacteria 28211|Alphaproteobacteria S MAPEG family MA20_30600 - - - - - - - - - - - MAPEG k59_94555_3 1177154.Y5S_03013 3.36e-18 79.0 COG3070@1|root,COG3070@2|Bacteria,1NAYG@1224|Proteobacteria,1SDXZ@1236|Gammaproteobacteria 1236|Gammaproteobacteria K TfoX N-terminal domain - - - - - - - - - - - - TfoX_N k59_485317_1 1122137.AQXF01000003_gene1898 5.9e-206 585.0 COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,2TQMR@28211|Alphaproteobacteria 28211|Alphaproteobacteria V ABC-type multidrug transport system ATPase and permease msbA2 - - ko:K06147 - - - - ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran k59_1672877_1 1415778.JQMM01000001_gene861 1.74e-69 228.0 COG0768@1|root,COG0768@2|Bacteria,1MUNY@1224|Proteobacteria,1RNGW@1236|Gammaproteobacteria,1J4BW@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Catalyzes cross-linking of the peptidoglycan cell wall at the division septum ftsI GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008144,GO:0008150,GO:0008658,GO:0008955,GO:0009987,GO:0016020,GO:0016021,GO:0016740,GO:0016757,GO:0016758,GO:0031224,GO:0031226,GO:0031406,GO:0032153,GO:0033218,GO:0033293,GO:0036094,GO:0042221,GO:0042493,GO:0043167,GO:0043168,GO:0043177,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051301,GO:0071944,GO:0097159,GO:1901363,GO:1901681 3.4.16.4 ko:K03587 ko00550,ko01501,map00550,map01501 - - - ko00000,ko00001,ko01000,ko01011,ko03036 - - iSSON_1240.SSON_0092 PBP_dimer,Transpeptidase k59_655450_1 1215114.BBIU01000011_gene1611 5.66e-55 180.0 COG0031@1|root,COG0031@2|Bacteria,1MUBE@1224|Proteobacteria,1RN6J@1236|Gammaproteobacteria 1236|Gammaproteobacteria E Belongs to the cysteine synthase cystathionine beta- synthase family cysM GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004124,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0016829,GO:0016846,GO:0019344,GO:0019752,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0080146,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.5.1.47 ko:K12339 ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230 M00021 R00897,R03132,R03601,R04859 RC00020,RC02814,RC02821,RC02876 ko00000,ko00001,ko00002,ko01000 - - iECP_1309.ECP_2444 PALP k59_993218_1 316407.85675342 2.53e-114 328.0 COG1143@1|root,COG1143@2|Bacteria,1MV90@1224|Proteobacteria,1RN32@1236|Gammaproteobacteria,3XMP4@561|Escherichia 1236|Gammaproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoI GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0030964,GO:0032991,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0045333,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0070469,GO:0070470,GO:0071944,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1990204 1.6.5.3 ko:K00338 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - e_coli_core.b2281,iAF1260.b2281,iAPECO1_1312.APECO1_4284,iB21_1397.B21_02166,iBWG_1329.BWG_2055,iE2348C_1286.E2348C_2421,iEC042_1314.EC042_2522,iEC55989_1330.EC55989_2525,iECABU_c1320.ECABU_c26130,iECBD_1354.ECBD_1380,iECB_1328.ECB_02206,iECDH10B_1368.ECDH10B_2443,iECDH1ME8569_1439.ECDH1ME8569_2218,iECD_1391.ECD_02206,iECED1_1282.ECED1_2745,iECH74115_1262.ECH74115_3420,iECIAI1_1343.ECIAI1_2355,iECIAI39_1322.ECIAI39_2428,iECNA114_1301.ECNA114_2371,iECO103_1326.ECO103_2745,iECO111_1330.ECO111_3029,iECO26_1355.ECO26_3269,iECOK1_1307.ECOK1_2514,iECP_1309.ECP_2320,iECS88_1305.ECS88_2428,iECSE_1348.ECSE_2538,iECSF_1327.ECSF_2158,iECSP_1301.ECSP_3155,iECUMN_1333.ECUMN_2620,iECW_1372.ECW_m2469,iECs_1301.ECs3165,iEKO11_1354.EKO11_1486,iETEC_1333.ETEC_2416,iEcDH1_1363.EcDH1_1376,iEcE24377_1341.EcE24377A_2574,iEcHS_1320.EcHS_A2430,iEcSMS35_1347.EcSMS35_2435,iEcolC_1368.EcolC_1371,iG2583_1286.G2583_2818,iJO1366.b2281,iJR904.b2281,iLF82_1304.LF82_1546,iNRG857_1313.NRG857_11550,iPC815.YPO2548,iSBO_1134.SBO_2314,iSFV_1184.SFV_2348,iSF_1195.SF2357,iSFxv_1172.SFxv_2601,iS_1188.S2492,iSbBS512_1146.SbBS512_E2657,iUMN146_1321.UM146_05410,iUMNK88_1353.UMNK88_2831,iUTI89_1310.UTI89_C2561,iWFL_1372.ECW_m2469,iY75_1357.Y75_RS11960,iZ_1308.Z3540,ic_1306.c2822 Fer4 k59_993218_2 316407.1799640 1.52e-34 122.0 COG0839@1|root,COG0839@2|Bacteria,1MWJV@1224|Proteobacteria,1S65T@1236|Gammaproteobacteria,3XMGS@561|Escherichia 1236|Gammaproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoJ GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008137,GO:0008150,GO:0008152,GO:0016020,GO:0016021,GO:0016491,GO:0016651,GO:0016655,GO:0030964,GO:0031224,GO:0031226,GO:0032991,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0050136,GO:0055114,GO:0070469,GO:0070470,GO:0071944,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1990204 1.6.5.3 ko:K00339 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - e_coli_core.b2280,iAF1260.b2280,iAPECO1_1312.APECO1_4285,iB21_1397.B21_02165,iBWG_1329.BWG_2054,iE2348C_1286.E2348C_2420,iEC042_1314.EC042_2521,iEC55989_1330.EC55989_2524,iECABU_c1320.ECABU_c26120,iECBD_1354.ECBD_1381,iECB_1328.ECB_02205,iECDH10B_1368.ECDH10B_2442,iECDH1ME8569_1439.ECDH1ME8569_2217,iECD_1391.ECD_02205,iECED1_1282.ECED1_2744,iECH74115_1262.ECH74115_3419,iECIAI1_1343.ECIAI1_2354,iECIAI39_1322.ECIAI39_2427,iECNA114_1301.ECNA114_2370,iECO103_1326.ECO103_2744,iECO111_1330.ECO111_3028,iECO26_1355.ECO26_3268,iECOK1_1307.ECOK1_2513,iECP_1309.ECP_2319,iECS88_1305.ECS88_2427,iECSE_1348.ECSE_2537,iECSF_1327.ECSF_2157,iECSP_1301.ECSP_3154,iECUMN_1333.ECUMN_2619,iECW_1372.ECW_m2468,iECs_1301.ECs3164,iEKO11_1354.EKO11_1487,iETEC_1333.ETEC_2415,iEcDH1_1363.EcDH1_1377,iEcE24377_1341.EcE24377A_2573,iEcHS_1320.EcHS_A2429,iEcSMS35_1347.EcSMS35_2434,iEcolC_1368.EcolC_1372,iJO1366.b2280,iJR904.b2280,iLF82_1304.LF82_1547,iNRG857_1313.NRG857_11545,iSBO_1134.SBO_2313,iSDY_1059.SDY_2476,iSFV_1184.SFV_2347,iSF_1195.SF2356,iSFxv_1172.SFxv_2600,iSSON_1240.SSON_2337,iS_1188.S2491,iSbBS512_1146.SbBS512_E2656,iUMN146_1321.UM146_05415,iUMNK88_1353.UMNK88_2830,iUTI89_1310.UTI89_C2560,iWFL_1372.ECW_m2468,iY75_1357.Y75_RS11955,iZ_1308.Z3539,ic_1306.c2821 Oxidored_q3 k59_1055115_1 1122137.AQXF01000003_gene2018 9.42e-30 110.0 COG1825@1|root,COG1825@2|Bacteria,1RDH0@1224|Proteobacteria,2U5P0@28211|Alphaproteobacteria 28211|Alphaproteobacteria J This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance ctc GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02897 ko03010,map03010 M00178 - - ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L25p,Ribosomal_TL5_C k59_1395200_1 408672.NBCG_04969 1.75e-76 233.0 COG0454@1|root,COG0454@2|Bacteria,2I66Q@201174|Actinobacteria 201174|Actinobacteria K Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_1 k59_826638_1 590998.Celf_0775 1.31e-10 67.0 COG0500@1|root,COG2226@2|Bacteria,2H9G5@201174|Actinobacteria 201174|Actinobacteria Q Methyltransferase type 11 pmtA - - - - - - - - - - - Methyltransf_11 k59_1223047_1 446470.Snas_4333 0.000595 46.6 COG1670@1|root,COG1670@2|Bacteria,2IT98@201174|Actinobacteria 201174|Actinobacteria J Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_3 k59_38958_1 1122137.AQXF01000003_gene2144 3.67e-138 415.0 COG1529@1|root,COG1529@2|Bacteria,1QTTJ@1224|Proteobacteria,2TQVK@28211|Alphaproteobacteria 28211|Alphaproteobacteria C COG1529 Aerobic-type carbon monoxide dehydrogenase large subunit CoxL CutL homologs MA20_34355 - 1.3.99.16 ko:K07303 - - - - ko00000,ko01000 - - - Ald_Xan_dh_C,Ald_Xan_dh_C2 k59_1783030_2 459495.SPLC1_S040970 0.000145 50.1 COG2197@1|root,COG2197@2|Bacteria,1G1P0@1117|Cyanobacteria,1H83W@1150|Oscillatoriales 1117|Cyanobacteria K COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain - - - - - - - - - - - - GerE,Response_reg k59_1115090_1 762376.AXYL_03381 2.11e-25 105.0 COG0559@1|root,COG0559@2|Bacteria,1N5XH@1224|Proteobacteria,2VHAJ@28216|Betaproteobacteria,3T6P6@506|Alcaligenaceae 28216|Betaproteobacteria U Belongs to the binding-protein-dependent transport system permease family - - - ko:K01997 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - BPD_transp_2 k59_1738094_1 575540.Isop_0401 5.11e-20 91.3 COG1032@1|root,COG1032@2|Bacteria,2IY6B@203682|Planctomycetes 203682|Planctomycetes C UPF0313 protein - - - - - - - - - - - - DUF3362,Radical_SAM,Radical_SAM_N k59_1738094_2 1146883.BLASA_2249 2.82e-16 78.2 COG2153@1|root,COG2153@2|Bacteria,2HU11@201174|Actinobacteria,4EW7E@85013|Frankiales 201174|Actinobacteria K Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - - - - - - - - - - Acetyltransf_10 k59_1062223_2 1122137.AQXF01000002_gene349 1.93e-47 168.0 COG1530@1|root,COG1530@2|Bacteria,1MV65@1224|Proteobacteria,2TRX2@28211|Alphaproteobacteria 28211|Alphaproteobacteria J Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs rne - 3.1.26.12 ko:K08300 ko03018,map03018 M00394 - - ko00000,ko00001,ko00002,ko01000,ko03009,ko03019 - - - RNase_E_G,S1 k59_1284122_1 316407.85674936 1.35e-162 466.0 COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,1RMBQ@1236|Gammaproteobacteria 1236|Gammaproteobacteria C belongs to the aldehyde dehydrogenase family feaB GO:0003674,GO:0003824,GO:0004029,GO:0006139,GO:0006576,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006805,GO:0006807,GO:0008150,GO:0008152,GO:0008957,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009308,GO:0009310,GO:0009410,GO:0009435,GO:0009987,GO:0016043,GO:0016491,GO:0016620,GO:0016903,GO:0018130,GO:0018958,GO:0018960,GO:0019336,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019607,GO:0019637,GO:0019674,GO:0022607,GO:0034641,GO:0034654,GO:0042178,GO:0042221,GO:0042402,GO:0042443,GO:0043933,GO:0044085,GO:0044106,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044271,GO:0044281,GO:0046196,GO:0046483,GO:0046496,GO:0047106,GO:0050896,GO:0051186,GO:0051188,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0051716,GO:0055086,GO:0055114,GO:0065003,GO:0070887,GO:0071466,GO:0071704,GO:0071840,GO:0072524,GO:0072525,GO:0090407,GO:0097164,GO:1901160,GO:1901161,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901615,GO:1901616 1.2.1.39 ko:K00146 ko00360,ko00643,ko01100,ko01120,map00360,map00643,map01100,map01120 - R02536 RC00080 ko00000,ko00001,ko01000 - - iYL1228.KPN_01455 Aldedh k59_45814_1 1117647.M5M_04675 2.06e-68 223.0 COG1160@1|root,COG1160@2|Bacteria,1MU9S@1224|Proteobacteria,1RMSF@1236|Gammaproteobacteria,1J4NG@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S GTPase that plays an essential role in the late steps of ribosome biogenesis der GO:0000027,GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005515,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006996,GO:0008150,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0022607,GO:0022613,GO:0022618,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0032794,GO:0034622,GO:0035639,GO:0036094,GO:0042254,GO:0042255,GO:0042273,GO:0043021,GO:0043022,GO:0043023,GO:0043167,GO:0043168,GO:0043933,GO:0044085,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:0097159,GO:0097216,GO:0097367,GO:1901265,GO:1901363 - ko:K03977 - - - - ko00000,ko03009 - - - KH_dom-like,MMR_HSR1 k59_1173925_2 1288494.EBAPG3_22130 4.73e-21 92.4 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2VHSB@28216|Betaproteobacteria,372E7@32003|Nitrosomonadales 28216|Betaproteobacteria T Sigma-54 interaction domain yfhA - - ko:K07715 ko02020,ko02024,map02020,map02024 M00502 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_271405_1 1121456.ATVA01000001_gene3074 2.39e-19 87.0 COG2204@1|root,COG2204@2|Bacteria,1N33V@1224|Proteobacteria,42U3U@68525|delta/epsilon subdivisions,2WQ8H@28221|Deltaproteobacteria,2MBNT@213115|Desulfovibrionales 28221|Deltaproteobacteria T response regulator, receiver - - - - - - - - - - - - Response_reg k59_1515501_1 946077.W5A_02085 5.08e-45 151.0 COG0745@1|root,COG0745@2|Bacteria,4NG7D@976|Bacteroidetes,1HWZ6@117743|Flavobacteriia 976|Bacteroidetes T Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain phoP - - ko:K07658 ko02020,map02020 M00434 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Trans_reg_C k59_1572942_1 118163.Ple7327_1106 0.000654 48.9 COG1520@1|root,COG2931@1|root,COG5384@1|root,COG1520@2|Bacteria,COG2931@2|Bacteria,COG5384@2|Bacteria 2|Bacteria J extracellular matrix structural constituent aprA GO:0003674,GO:0003824,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009405,GO:0010467,GO:0016485,GO:0016787,GO:0019538,GO:0031638,GO:0043170,GO:0044238,GO:0044419,GO:0051604,GO:0051704,GO:0071704,GO:0140096,GO:1901564 3.4.24.40 ko:K01406 ko01503,map01503 - - - ko00000,ko00001,ko01000,ko01002 - - - HemolysinCabind,Peptidase_M10,Peptidase_M10_C,Reprolysin_4 k59_945303_1 550540.Fbal_3797 1.61e-71 234.0 COG0445@1|root,COG0445@2|Bacteria,1MU6F@1224|Proteobacteria,1RMM1@1236|Gammaproteobacteria 1236|Gammaproteobacteria D NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 gidA GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009314,GO:0009411,GO:0009416,GO:0009451,GO:0009628,GO:0009987,GO:0010467,GO:0016070,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0050896,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901363 - ko:K03495 - - R08701 RC00053,RC00209,RC00870 ko00000,ko03016,ko03036 - - - GIDA,GIDA_assoc k59_1790573_1 493475.GARC_0289 9.09e-12 63.9 COG2307@1|root,COG2307@2|Bacteria,1MVZK@1224|Proteobacteria,1RN2Y@1236|Gammaproteobacteria,466CP@72275|Alteromonadaceae 1236|Gammaproteobacteria S A predicted alpha-helical domain with a conserved ER motif. - - - - - - - - - - - - Alpha-E k59_1790573_2 435908.IDSA_10095 8.25e-88 271.0 COG2308@1|root,COG2308@2|Bacteria,1MUAD@1224|Proteobacteria,1RNAF@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Circularly permuted ATP-grasp type 2 - - - - - - - - - - - - CP_ATPgrasp_2 k59_663358_1 377629.TERTU_3792 1.1e-40 134.0 COG1278@1|root,COG1278@2|Bacteria,1N6Q5@1224|Proteobacteria,1SCA7@1236|Gammaproteobacteria,2PNYZ@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria K Cold shock protein domain cspG - - ko:K03704 - - - - ko00000,ko03000 - - - CSD k59_894585_1 1123073.KB899241_gene2071 7.78e-127 383.0 COG0365@1|root,COG0365@2|Bacteria,1MUX7@1224|Proteobacteria,1RPGT@1236|Gammaproteobacteria,1X5HI@135614|Xanthomonadales 135614|Xanthomonadales I Acetyl-coenzyme A synthetase N-terminus - - - - - - - - - - - - ACAS_N,AMP-binding k59_1625762_1 1191523.MROS_0476 2.06e-59 201.0 COG0388@1|root,COG0454@1|root,COG0388@2|Bacteria,COG0456@2|Bacteria 2|Bacteria K acetyltransferase yhcX - - ko:K11206 - - - - ko00000,ko01000 - - - Acetyltransf_1,CN_hydrolase k59_1115134_1 203124.Tery_2843 1.69e-44 161.0 COG0028@1|root,COG0028@2|Bacteria,1G17K@1117|Cyanobacteria,1H7E4@1150|Oscillatoriales 1117|Cyanobacteria H TIGRFAM acetolactate synthase, large subunit, biosynthetic type ilvB - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N,zinc_ribbon_2 k59_894591_1 1121468.AUBR01000073_gene1014 5.72e-59 192.0 COG3328@1|root,COG3328@2|Bacteria,1V116@1239|Firmicutes,24D8K@186801|Clostridia 186801|Clostridia L Transposase, Mutator family - - - - - - - - - - - - Transposase_mut k59_213461_1 997346.HMPREF9374_1229 8.2e-76 244.0 COG0301@1|root,COG0301@2|Bacteria,1TPNW@1239|Firmicutes,4HAV9@91061|Bacilli,27AYE@186824|Thermoactinomycetaceae 91061|Bacilli H THUMP thiI - 2.8.1.4 ko:K03151 ko00730,ko01100,ko04122,map00730,map01100,map04122 - R07461 - ko00000,ko00001,ko01000,ko03016 - - - THUMP,ThiI k59_156259_1 291985.CCSI01000003_gene352 2.23e-20 92.4 COG0624@1|root,COG0624@2|Bacteria,1MWJS@1224|Proteobacteria,2TUHT@28211|Alphaproteobacteria,2K1MW@204457|Sphingomonadales 204457|Sphingomonadales E Acetylornithine deacetylase Succinyl-diaminopimelate - - - - - - - - - - - - M20_dimer,Peptidase_M20,Peptidase_M28 k59_1062251_1 1203611.KB894542_gene670 2.18e-23 99.8 COG0499@1|root,COG0499@2|Bacteria,4NEKE@976|Bacteroidetes,2FPWZ@200643|Bacteroidia,22UQ1@171550|Rikenellaceae 976|Bacteroidetes H May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine ahcY GO:0000096,GO:0003674,GO:0003824,GO:0004013,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006534,GO:0006555,GO:0006575,GO:0006725,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009066,GO:0009069,GO:0009116,GO:0009119,GO:0009987,GO:0016787,GO:0016801,GO:0016802,GO:0017144,GO:0019752,GO:0033353,GO:0034641,GO:0042278,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046128,GO:0046439,GO:0046483,GO:0046498,GO:0046500,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564,GO:1901605,GO:1901657 3.3.1.1 ko:K01251 ko00270,ko01100,map00270,map01100 M00035 R00192,R04936 RC00056,RC00069,RC01161,RC01243 ko00000,ko00001,ko00002,ko01000,ko01009,ko04147 - - - AdoHcyase,AdoHcyase_NAD k59_437003_2 1537715.JQFJ01000002_gene1884 1.39e-22 101.0 COG2271@1|root,COG2271@2|Bacteria,1P3P1@1224|Proteobacteria,2TVM7@28211|Alphaproteobacteria,2K00U@204457|Sphingomonadales 204457|Sphingomonadales G Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 k59_1062253_2 935863.AWZR01000012_gene2544 1.39e-27 107.0 COG2863@1|root,COG2863@2|Bacteria,1MZU1@1224|Proteobacteria,1SBJR@1236|Gammaproteobacteria,1X7P5@135614|Xanthomonadales 135614|Xanthomonadales C cytochrome - - - - - - - - - - - - Cytochrom_C k59_1625774_1 1123288.SOV_1c09840 7.65e-19 84.7 COG1832@1|root,COG1832@2|Bacteria,1V7C7@1239|Firmicutes,4H4R5@909932|Negativicutes 909932|Negativicutes S domain protein - - - ko:K06929 - - - - ko00000 - - - CoA_binding_2 k59_213475_1 929703.KE386491_gene3993 1.04e-23 106.0 COG1404@1|root,COG1404@2|Bacteria,4NF1M@976|Bacteroidetes,47NC9@768503|Cytophagia 976|Bacteroidetes O Subtilase family - - - - - - - - - - - - PKD,Peptidase_S8 k59_1115157_1 1210884.HG799469_gene14098 2.88e-32 125.0 COG1003@1|root,COG1003@2|Bacteria,2IYB9@203682|Planctomycetes 203682|Planctomycetes E The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor gcvPB - 1.4.4.2 ko:K00281,ko:K00283 ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200 M00532 R01221,R03425 RC00022,RC00929,RC02834,RC02880 ko00000,ko00001,ko00002,ko01000 - - - Aminotran_5,GDC-P k59_1115157_2 910964.GEAM_2571 1.4e-05 48.9 COG4783@1|root,COG4783@2|Bacteria,1MVFV@1224|Proteobacteria,1RP5S@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Functions as both a chaperone and a metalloprotease. Maintains the integrity of the outer membrane by promoting either the assembly or the elimination of outer membrane proteins, depending on their folding state bepA GO:0003674,GO:0003756,GO:0003824,GO:0004175,GO:0004222,GO:0005488,GO:0005575,GO:0005623,GO:0006457,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009056,GO:0009057,GO:0009987,GO:0016020,GO:0016043,GO:0016787,GO:0016853,GO:0016860,GO:0016864,GO:0019538,GO:0022607,GO:0030163,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043163,GO:0043165,GO:0043167,GO:0043169,GO:0043170,GO:0044085,GO:0044091,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044464,GO:0045229,GO:0046872,GO:0051603,GO:0061024,GO:0061077,GO:0070011,GO:0071704,GO:0071709,GO:0071840,GO:0140096,GO:1901564,GO:1901565,GO:1901575 - - - - - - - - - - Peptidase_M48,TPR_19 k59_774932_1 1182590.BN5_00462 6.4e-84 255.0 COG0225@1|root,COG0225@2|Bacteria,1MVUS@1224|Proteobacteria,1RNWU@1236|Gammaproteobacteria,1YENU@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria O Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine msrA GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006807,GO:0006950,GO:0006979,GO:0008113,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016667,GO:0016671,GO:0019538,GO:0030091,GO:0033744,GO:0036456,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0055114,GO:0071704,GO:1901564 1.8.4.11 ko:K07304 - - - - ko00000,ko01000 - - iECSE_1348.ECSE_4525 PMSR k59_663392_1 1122599.AUGR01000009_gene2459 4.99e-119 362.0 COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,1RQUR@1236|Gammaproteobacteria,1XIN6@135619|Oceanospirillales 135619|Oceanospirillales F Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen - - 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - LAGLIDADG_3,Ribonuc_red_lgC,Ribonuc_red_lgN k59_437020_1 1282362.AEAC466_10300 3.48e-81 264.0 COG3451@1|root,COG3451@2|Bacteria,1MXH0@1224|Proteobacteria,2TR1U@28211|Alphaproteobacteria,2KEYI@204458|Caulobacterales 204458|Caulobacterales U Type VI secretion protein - - - ko:K03199 ko03070,map03070 M00333 - - ko00000,ko00001,ko00002,ko02044 3.A.7 - - CagE_TrbE_VirB k59_724480_1 1318628.MARLIPOL_17283 5.18e-21 108.0 COG3419@1|root,COG3419@2|Bacteria,1NUAV@1224|Proteobacteria,1RPV3@1236|Gammaproteobacteria,46578@72275|Alteromonadaceae 1236|Gammaproteobacteria NU Tfp pilus assembly protein tip-associated adhesin pilY1 - - ko:K02674 - - - - ko00000,ko02035,ko02044 - - - Neisseria_PilC,VWA_2 k59_1403130_1 381666.PHG101 4.03e-199 562.0 COG3464@1|root,COG3464@2|Bacteria,1MV5J@1224|Proteobacteria,2VKAK@28216|Betaproteobacteria,1K5RX@119060|Burkholderiaceae 28216|Betaproteobacteria L Transposase - - - - - - - - - - - - DDE_Tnp_ISL3,HTH_Tnp_ISL3 k59_1115177_1 1123236.KB899389_gene2184 7.51e-17 84.3 COG0287@1|root,COG1605@1|root,COG0287@2|Bacteria,COG1605@2|Bacteria,1MVUT@1224|Proteobacteria,1RQB3@1236|Gammaproteobacteria,465BQ@72275|Alteromonadaceae 1236|Gammaproteobacteria E chorismate mutase tyrA GO:0000166,GO:0003674,GO:0003824,GO:0004106,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006558,GO:0006570,GO:0006571,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008977,GO:0009058,GO:0009072,GO:0009073,GO:0009094,GO:0009095,GO:0009987,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0016853,GO:0016866,GO:0017144,GO:0019438,GO:0019752,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0070403,GO:0071704,GO:0097159,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902221,GO:1902223 1.3.1.12,5.4.99.5 ko:K04517,ko:K14187 ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230 M00024,M00025 R01715,R01728 RC00125,RC03116 ko00000,ko00001,ko00002,ko01000 - - iECUMN_1333.ECUMN_2925 ACT,CM_2,PDH k59_1572990_1 1121918.ARWE01000001_gene1046 2.45e-71 235.0 COG0760@1|root,COG0760@2|Bacteria,1MWV0@1224|Proteobacteria,42MPK@68525|delta/epsilon subdivisions,2WJM1@28221|Deltaproteobacteria,43RYI@69541|Desulfuromonadales 28221|Deltaproteobacteria O SurA N-terminal domain nifM - 5.2.1.8 ko:K03770 - - - - ko00000,ko01000,ko03110 - - - Rotamase,Rotamase_2,Rotamase_3,SurA_N_3 k59_101811_1 1283300.ATXB01000002_gene2891 3.35e-08 55.8 COG2271@1|root,COG2271@2|Bacteria,1MVV4@1224|Proteobacteria,1T3JH@1236|Gammaproteobacteria 1236|Gammaproteobacteria G Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 k59_101811_2 1122137.AQXF01000001_gene3401 1.24e-78 244.0 COG0451@1|root,COG0451@2|Bacteria,1MW32@1224|Proteobacteria,2TTTU@28211|Alphaproteobacteria 28211|Alphaproteobacteria GM Nad-dependent epimerase dehydratase - - 1.1.1.219 ko:K00091 - - - - ko00000,ko01000 - - - Epimerase k59_1002002_1 1229909.NSED_09845 7.28e-06 48.5 COG0300@1|root,arCOG01263@2157|Archaea,41SXQ@651137|Thaumarchaeota 651137|Thaumarchaeota S Belongs to the short-chain dehydrogenases reductases (SDR) family - - - ko:K07124 - - - - ko00000 - - - adh_short k59_612116_1 1120963.KB894492_gene1743 1.88e-67 217.0 COG0240@1|root,COG0240@2|Bacteria,1MUU3@1224|Proteobacteria,1RPQ7@1236|Gammaproteobacteria,2Q0WT@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria I Glycerol-3-phosphate dehydrogenase gpsA GO:0003674,GO:0003824,GO:0004367,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006072,GO:0006629,GO:0006644,GO:0006650,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0045017,GO:0046474,GO:0046486,GO:0047952,GO:0052646,GO:0055114,GO:0071704,GO:0090407,GO:1901135,GO:1901576 1.1.1.94 ko:K00057 ko00564,ko01110,map00564,map01110 - R00842,R00844 RC00029 ko00000,ko00001,ko01000 - - iJN746.PP_4169,iSFV_1184.SFV_3923 NAD_Gly3P_dh_C,NAD_Gly3P_dh_N k59_1230843_1 436308.Nmar_0031 3.26e-13 69.7 arCOG10512@1|root,arCOG10512@2157|Archaea,41T3J@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1285169_1 1220534.B655_2377 3.07e-14 76.3 COG1396@1|root,arCOG01865@2157|Archaea,2XWHC@28890|Euryarchaeota,23PJF@183925|Methanobacteria 183925|Methanobacteria K Cro/C1-type HTH DNA-binding domain - - - - - - - - - - - - Cupin_2,HTH_3 k59_775721_1 318996.AXAZ01000073_gene3366 1.03e-45 160.0 COG3547@1|root,COG3547@2|Bacteria,1MW0N@1224|Proteobacteria,2TUGE@28211|Alphaproteobacteria,3JX5I@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria L PFAM transposase IS116 IS110 IS902 family - - - ko:K07486 - - - - ko00000 - - - DEDD_Tnp_IS110,Transposase_20 k59_1681964_1 153948.NAL212_1474 1.02e-54 187.0 COG0477@1|root,COG0477@2|Bacteria,1MXZ3@1224|Proteobacteria,2VTVG@28216|Betaproteobacteria,3723C@32003|Nitrosomonadales 28216|Betaproteobacteria EGP Transmembrane secretion effector - - - ko:K08225 - - - - ko00000,ko02000 2.A.1.38 - - MFS_3 k59_549192_1 646529.Desaci_4653 5.41e-100 309.0 COG0504@1|root,COG0504@2|Bacteria,1TP34@1239|Firmicutes,2482E@186801|Clostridia,260W1@186807|Peptococcaceae 186801|Clostridia F Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates pyrG - 6.3.4.2 ko:K01937 ko00240,ko01100,map00240,map01100 M00052 R00571,R00573 RC00010,RC00074 ko00000,ko00001,ko00002,ko01000 - - iHN637.CLJU_RS01075 CTP_synth_N,GATase k59_157246_1 1120972.AUMH01000026_gene2828 1.75e-88 274.0 COG0078@1|root,COG0078@2|Bacteria,1TPF2@1239|Firmicutes,4H9X8@91061|Bacilli,2783Z@186823|Alicyclobacillaceae 91061|Bacilli E Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline argF GO:0000050,GO:0003674,GO:0003824,GO:0004585,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0016743,GO:0019627,GO:0019752,GO:0034641,GO:0042450,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.1.3.3 ko:K00611 ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230 M00029,M00844 R01398 RC00096 ko00000,ko00001,ko00002,ko01000 - - - OTCace,OTCace_N k59_157246_2 637389.Acaty_c0050 2.65e-06 53.5 COG0484@1|root,COG0484@2|Bacteria,1MUZ4@1224|Proteobacteria,1RP09@1236|Gammaproteobacteria,2NCG9@225057|Acidithiobacillales 225057|Acidithiobacillales O DnaJ C terminal domain - - - ko:K05516 - - - - ko00000,ko03036,ko03110 - - - DnaJ,DnaJ_C k59_493608_1 1187848.AJYQ01000003_gene410 7.33e-127 377.0 COG3653@1|root,COG3653@2|Bacteria,1MWWY@1224|Proteobacteria,1TFGA@1236|Gammaproteobacteria,1XXNF@135623|Vibrionales 135623|Vibrionales Q Amidohydrolase family - - - - - - - - - - - - Amidohydro_3 k59_437976_1 1144275.COCOR_04260 4.29e-42 166.0 COG0642@1|root,COG0745@1|root,COG2202@1|root,COG0745@2|Bacteria,COG2202@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,42M0Y@68525|delta/epsilon subdivisions,2X791@28221|Deltaproteobacteria 28221|Deltaproteobacteria T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - GAF_2,HATPase_c,HisKA,Response_reg k59_612156_1 686340.Metal_1832 1.79e-83 277.0 COG1201@1|root,COG1201@2|Bacteria,1MUSW@1224|Proteobacteria,1RSNV@1236|Gammaproteobacteria,1XDT8@135618|Methylococcales 135618|Methylococcales L DEAD DEAH box - - - ko:K03724 - - - - ko00000,ko01000,ko03400 - - - DEAD,DEAD_assoc,Helicase_C k59_1341436_1 207954.MED92_14598 2.61e-08 51.6 2EFSX@1|root,339IW@2|Bacteria,1NG97@1224|Proteobacteria,1TINA@1236|Gammaproteobacteria,1XMSG@135619|Oceanospirillales 135619|Oceanospirillales S Protein of unknown function (DUF2986) - - - - - - - - - - - - DUF2986 k59_1341436_2 1230343.CANP01000048_gene3700 2.75e-27 111.0 COG2303@1|root,COG4757@1|root,COG2303@2|Bacteria,COG4757@2|Bacteria,1NV3A@1224|Proteobacteria,1RNQ5@1236|Gammaproteobacteria 1236|Gammaproteobacteria E COG2303 Choline dehydrogenase and related flavoproteins - - 1.1.3.6 ko:K03333 ko00984,ko01120,map00984,map01120 - R01459 RC00146 ko00000,ko00001,ko01000 - - - GMC_oxred_C,GMC_oxred_N,NAD_binding_8 k59_46836_1 1238190.AMQY01000021_gene1593 4.87e-32 128.0 COG0749@1|root,COG0749@2|Bacteria,1MWX7@1224|Proteobacteria,1S0Q1@1236|Gammaproteobacteria 1236|Gammaproteobacteria L ORF located using Glimmer RBSfinder - - 2.7.7.7 ko:K02334 - - - - ko00000,ko01000 - - - DNA_pol_A,DNA_pol_A_exo1 k59_664415_1 391038.Bphy_1367 9.58e-36 137.0 COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,2VH16@28216|Betaproteobacteria,1K1IY@119060|Burkholderiaceae 28216|Betaproteobacteria L Belongs to the DEAD box helicase family rhlE1 GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008026,GO:0008104,GO:0008150,GO:0008186,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032991,GO:0033036,GO:0035770,GO:0036464,GO:0042623,GO:0043186,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044424,GO:0044444,GO:0044464,GO:0045495,GO:0051179,GO:0060293,GO:0070035,GO:0140098,GO:1990904 - - - - - - - - - - DEAD,Helicase_C k59_664415_2 1227349.C170_18662 1.41e-13 70.9 COG0513@1|root,COG0513@2|Bacteria,1TPAP@1239|Firmicutes,4HBVK@91061|Bacilli,26QF5@186822|Paenibacillaceae 91061|Bacilli L helicase deaD3 - 3.6.4.13 ko:K05592 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03009,ko03019 - - - DEAD,Helicase_C k59_102846_1 436308.Nmar_1613 1.03e-46 160.0 COG0402@1|root,arCOG00692@2157|Archaea,41S61@651137|Thaumarchaeota 651137|Thaumarchaeota F Amidohydrolase family - - - - - - - - - - - - Amidohydro_1 k59_102846_2 1229909.NSED_08725 2e-40 139.0 COG1985@1|root,arCOG01484@2157|Archaea,41SK2@651137|Thaumarchaeota 651137|Thaumarchaeota H RibD C-terminal domain - - 1.1.1.302 ko:K14654 ko00740,ko01100,map00740,map01100 - R09375,R09376 RC00933 ko00000,ko00001,ko01000 - - - RibD_C k59_895555_1 1254432.SCE1572_51635 4.61e-25 106.0 COG3250@1|root,COG3250@2|Bacteria,1R5U9@1224|Proteobacteria 1224|Proteobacteria G Vitamin K-dependent gamma-carboxylase - - - - - - - - - - - - VKG_Carbox k59_946278_1 555793.WSK_2979 1.27e-95 288.0 COG0654@1|root,COG0654@2|Bacteria,1MV8T@1224|Proteobacteria,2TRB8@28211|Alphaproteobacteria,2K1NN@204457|Sphingomonadales 204457|Sphingomonadales CH Catalyzes the formation of protocatechuate from 4-hydroxybenzoate - - 1.14.13.2 ko:K00481 ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220 - R01298 RC00046 ko00000,ko00001,ko01000 - - - FAD_binding_3 k59_946278_2 1088721.NSU_3637 7.6e-70 221.0 COG0662@1|root,COG2207@1|root,COG0662@2|Bacteria,COG2207@2|Bacteria,1MXDJ@1224|Proteobacteria,2VFB5@28211|Alphaproteobacteria,2KDW3@204457|Sphingomonadales 204457|Sphingomonadales K helix_turn_helix, arabinose operon control protein - - - ko:K18954 - - - - ko00000,ko03000 - - - AraC_binding,HTH_18 k59_157288_1 748247.AZKH_1022 2.19e-74 235.0 COG0722@1|root,COG0722@2|Bacteria,1MU5Q@1224|Proteobacteria,2VH4W@28216|Betaproteobacteria,2KU9M@206389|Rhodocyclales 206389|Rhodocyclales E Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) aroG - 2.5.1.54 ko:K01626 ko00400,ko01100,ko01110,ko01130,ko01230,ko02024,map00400,map01100,map01110,map01130,map01230,map02024 M00022 R01826 RC00435 ko00000,ko00001,ko00002,ko01000 - - - DAHP_synth_1 k59_1682029_1 435590.BVU_2317 6.44e-20 84.3 COG0698@1|root,COG0698@2|Bacteria,4NNSU@976|Bacteroidetes,2FT1X@200643|Bacteroidia,4ANC4@815|Bacteroidaceae 976|Bacteroidetes G Ribose 5-phosphate isomerase rpiB - 5.3.1.6 ko:K01808 ko00030,ko00051,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00051,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01056,R09030 RC00376,RC00434 ko00000,ko00001,ko00002,ko01000 - - - LacAB_rpiB k59_1682029_2 937777.Deipe_3442 3.69e-49 168.0 COG0112@1|root,COG0112@2|Bacteria,1WINZ@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus E Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism glyA - 2.1.2.1 ko:K00600 ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523 M00140,M00141,M00346,M00532 R00945,R09099 RC00022,RC00112,RC01583,RC02958 ko00000,ko00001,ko00002,ko01000 - - - SHMT k59_725402_1 1122137.AQXF01000002_gene97 2.92e-82 261.0 COG0187@1|root,COG0187@2|Bacteria,1MVH1@1224|Proteobacteria,2TQZV@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule parE - - ko:K02622 - - - - ko00000,ko01000,ko02048,ko03032,ko03036 - - - DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim k59_725402_2 1411123.JQNH01000001_gene2014 3.53e-19 85.1 COG2267@1|root,COG2267@2|Bacteria,1QUZX@1224|Proteobacteria,2TWE4@28211|Alphaproteobacteria 28211|Alphaproteobacteria I Alpha beta hydrolase - - - - - - - - - - - - Abhydrolase_1,Abhydrolase_6 k59_214559_1 1267535.KB906767_gene4469 5.8e-21 92.0 COG0085@1|root,COG0085@2|Bacteria,3Y36G@57723|Acidobacteria,2JIQM@204432|Acidobacteriia 204432|Acidobacteriia K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoB - 2.7.7.6 ko:K03043 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7 k59_612220_1 316407.1742730 6.05e-107 318.0 COG0477@1|root,COG2814@2|Bacteria,1MU9G@1224|Proteobacteria,1RM9G@1236|Gammaproteobacteria,3XM7H@561|Escherichia 1236|Gammaproteobacteria EGP transmembrane transport ydhP GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K18567,ko:K19577 - - - - ko00000,ko02000 2.A.1.2.25,2.A.1.2.65 - - MFS_1 k59_1791510_1 1353276.JADR01000009_gene1899 1.66e-08 63.5 2DI2U@1|root,301UZ@2|Bacteria,4NJKE@976|Bacteroidetes,1HWZY@117743|Flavobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_157305_1 391625.PPSIR1_17450 3.14e-25 105.0 COG1396@1|root,COG1396@2|Bacteria,1MWUC@1224|Proteobacteria,430XD@68525|delta/epsilon subdivisions,2WW2B@28221|Deltaproteobacteria,2YVFP@29|Myxococcales 28221|Deltaproteobacteria K Helix-turn-helix XRE-family like proteins - - - - - - - - - - - - HTH_31 k59_214561_1 1196835.A458_19890 1.71e-17 86.3 COG2172@1|root,COG2172@2|Bacteria,1RD6C@1224|Proteobacteria,1S4BM@1236|Gammaproteobacteria,1Z057@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria T Anti-sigma regulatory factor (Ser Thr protein kinase) - - - - - - - - - - - - HATPase_c_2,SpoIIE k59_214561_2 1463900.JOIX01000001_gene6308 8.08e-28 106.0 COG2172@1|root,COG2172@2|Bacteria,2IKM9@201174|Actinobacteria 201174|Actinobacteria T anti-sigma regulatory factor rsbT - 2.7.11.1 ko:K17752 - - - - ko00000,ko01000,ko01001,ko03021 - - - HATPase_c,HATPase_c_2,Sigma70_r2 k59_835039_1 519989.ECTPHS_03642 6.64e-46 165.0 COG0608@1|root,COG0608@2|Bacteria,1MU1M@1224|Proteobacteria,1RMF4@1236|Gammaproteobacteria,1WW9D@135613|Chromatiales 135613|Chromatiales L single-stranded-DNA-specific exonuclease RecJ - - - ko:K07462 ko03410,ko03430,ko03440,map03410,map03430,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DHH,DHHA1 k59_1174939_1 1121875.KB907549_gene1851 3.03e-09 57.4 COG0702@1|root,COG0702@2|Bacteria,4NQ3G@976|Bacteroidetes,1I2U6@117743|Flavobacteriia 976|Bacteroidetes GM Complex I intermediate-associated protein 30 - - - - - - - - - - - - CIA30 k59_1574002_1 1288826.MSNKSG1_00556 1.92e-107 322.0 COG0055@1|root,COG0055@2|Bacteria,1N6UZ@1224|Proteobacteria,1RNQW@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits - - 3.6.3.14 ko:K02112 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - - ATP-synt_ab,ATP-synt_ab_N k59_1341483_1 391603.FBALC1_15282 4.41e-101 316.0 COG3250@1|root,COG3250@2|Bacteria,4NE7H@976|Bacteroidetes,1HX95@117743|Flavobacteriia 976|Bacteroidetes G Belongs to the glycosyl hydrolase 2 family - - 3.2.1.25 ko:K01192 ko00511,ko04142,map00511,map04142 - - - ko00000,ko00001,ko01000 - - - Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N k59_102874_1 1120948.KB903225_gene5523 2.52e-125 380.0 COG1894@1|root,COG1894@2|Bacteria,2GMMC@201174|Actinobacteria,4E076@85010|Pseudonocardiales 201174|Actinobacteria C NADH-ubiquinone oxidoreductase-F iron-sulfur binding region - - 1.17.1.9,1.6.5.3 ko:K00122,ko:K00335 ko00190,ko00630,ko00680,ko01100,ko01120,ko01200,map00190,map00630,map00680,map01100,map01120,map01200 M00144 R00519,R11945 RC00061,RC02796 ko00000,ko00001,ko00002,ko01000 3.D.1 - - 2Fe-2S_thioredx,Complex1_51K,NADH_4Fe-4S,SLBB k59_1239965_1 1123037.AUDE01000013_gene516 2.36e-51 170.0 COG0811@1|root,COG0811@2|Bacteria,4NEA2@976|Bacteroidetes,1HXZK@117743|Flavobacteriia 976|Bacteroidetes U Mota tolq exbb proton channel exbB - - ko:K03561 - - - - ko00000,ko02000 1.A.30.2.1 - - MotA_ExbB k59_1239965_2 983544.Lacal_0709 1.09e-61 199.0 COG0252@1|root,COG0252@2|Bacteria,4NE2Z@976|Bacteroidetes,1HWMJ@117743|Flavobacteriia 976|Bacteroidetes EJ GlutRNAGln amidotransferase subunit D ansA - 3.5.1.1 ko:K01424 ko00250,ko00460,ko01100,ko01110,map00250,map00460,map01100,map01110 - R00485 RC00010,RC02798 ko00000,ko00001,ko01000 - - - Asparaginase k59_1239967_1 1121013.P873_01050 5.45e-54 181.0 COG0002@1|root,COG0002@2|Bacteria,1MVJ6@1224|Proteobacteria,1RNMX@1236|Gammaproteobacteria,1X32E@135614|Xanthomonadales 135614|Xanthomonadales E Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde argC - 1.2.1.38 ko:K00145 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028,M00845 R03443 RC00684 ko00000,ko00001,ko00002,ko01000 - - - Semialdhyde_dh,Semialdhyde_dhC k59_785071_1 1122137.AQXF01000006_gene895 8.34e-89 265.0 COG1489@1|root,COG1489@2|Bacteria,1MUC3@1224|Proteobacteria,2U10V@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Belongs to the SfsA family sfsA - - ko:K06206 - - - - ko00000 - - - SfsA k59_1464417_1 1268237.G114_06857 1.25e-16 85.5 2DBW6@1|root,2ZBEP@2|Bacteria,1QUH5@1224|Proteobacteria,1RY0G@1236|Gammaproteobacteria 1236|Gammaproteobacteria C TIGRFAM decaheme c-type cytochrome, OmcA MtrC family - - - - - - - - - - - - Cytochrome_C7 k59_785079_1 991905.SL003B_3096 6.69e-23 102.0 COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,2TRZD@28211|Alphaproteobacteria,4BR82@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria P Cation transporter/ATPase, N-terminus - - 3.6.3.8 ko:K01537 - - - - ko00000,ko01000 3.A.3.2 - - Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3 k59_1239975_2 1123230.ARQJ01000020_gene2239 7.96e-08 56.2 COG0745@1|root,COG0745@2|Bacteria,1TS8Z@1239|Firmicutes,4HC86@91061|Bacilli 91061|Bacilli KT COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain - - - - - - - - - - - - Response_reg,Trans_reg_C k59_56379_1 436308.Nmar_1525 5.47e-06 47.4 COG0042@1|root,arCOG00604@2157|Archaea 2157|Archaea J Dihydrouridine synthase (Dus) dusA1 - - - - - - - - - - - Dus k59_447444_1 1122134.KB893651_gene1908 1.65e-26 101.0 COG3791@1|root,COG3791@2|Bacteria,1N031@1224|Proteobacteria,1S8W1@1236|Gammaproteobacteria,1XKBY@135619|Oceanospirillales 135619|Oceanospirillales S Glutathione-dependent formaldehyde-activating enzyme - - - - - - - - - - - - GFA k59_1011075_1 1198232.CYCME_0104 1.87e-65 221.0 COG1033@1|root,COG1033@2|Bacteria,1MUE1@1224|Proteobacteria,1RPIP@1236|Gammaproteobacteria,46225@72273|Thiotrichales 72273|Thiotrichales S MMPL family - - - ko:K07003 - - - - ko00000 - - - MMPL k59_785097_1 1268635.Loa_02781 3.9e-91 283.0 COG1875@1|root,COG1875@2|Bacteria,1MUX1@1224|Proteobacteria,1RMQN@1236|Gammaproteobacteria,1JD3G@118969|Legionellales 118969|Legionellales T Large family of predicted nucleotide-binding domains phoH - - ko:K07175 - - - - ko00000 - - - PIN_4,PhoH k59_1125444_1 1125863.JAFN01000001_gene34 1.1e-109 334.0 COG0112@1|root,COG0112@2|Bacteria,1MUIS@1224|Proteobacteria,42M0T@68525|delta/epsilon subdivisions,2WJ3C@28221|Deltaproteobacteria 28221|Deltaproteobacteria E Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism glyA - 2.1.2.1 ko:K00600 ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523 M00140,M00141,M00346,M00532 R00945,R09099 RC00022,RC00112,RC01583,RC02958 ko00000,ko00001,ko00002,ko01000 - - - SHMT k59_1125446_1 203122.Sde_0065 1.4e-92 284.0 COG1055@1|root,COG1055@2|Bacteria,1MUH8@1224|Proteobacteria,1RPSM@1236|Gammaproteobacteria,46541@72275|Alteromonadaceae 1236|Gammaproteobacteria P COG1055 Na H antiporter NhaD and related arsenite permeases nhaD - - - - - - - - - - - CitMHS k59_844737_1 1122194.AUHU01000011_gene1649 2.91e-80 244.0 COG0220@1|root,COG0220@2|Bacteria,1MUWJ@1224|Proteobacteria,1RMFG@1236|Gammaproteobacteria,464N4@72275|Alteromonadaceae 1236|Gammaproteobacteria J Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA trmB GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008176,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0034708,GO:0036265,GO:0043170,GO:0043412,GO:0043414,GO:0043527,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0106004,GO:0140098,GO:0140101,GO:1901360,GO:1902494,GO:1990234 2.1.1.33 ko:K03439 - - - - ko00000,ko01000,ko03016 - - - Methyltransf_4 k59_166659_1 1121935.AQXX01000127_gene1210 6.65e-125 367.0 COG0174@1|root,COG0174@2|Bacteria,1MU6V@1224|Proteobacteria,1RPNZ@1236|Gammaproteobacteria,1XHHJ@135619|Oceanospirillales 1224|Proteobacteria E Belongs to the glutamine synthetase family glnA1 - 6.3.1.2 ko:K01915 ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 - R00253 RC00010,RC02798 ko00000,ko00001,ko01000,ko04147 - - - Gln-synt_C k59_955614_1 378806.STAUR_5808 1.35e-76 259.0 COG1858@1|root,COG2706@1|root,COG3391@1|root,COG1858@2|Bacteria,COG2706@2|Bacteria,COG3391@2|Bacteria,1R66T@1224|Proteobacteria 1224|Proteobacteria C amine dehydrogenase activity - - - - - - - - - - - - Lactonase k59_56395_2 436308.Nmar_1338 5.99e-46 163.0 COG4742@1|root,arCOG04362@2157|Archaea,41SGE@651137|Thaumarchaeota 651137|Thaumarchaeota K Transcriptional regulator - - - - - - - - - - - - HTH_20,HTH_5 k59_168191_3 933262.AXAM01000053_gene2713 1.58e-48 170.0 COG4770@1|root,COG5016@1|root,COG4770@2|Bacteria,COG5016@2|Bacteria,1P6RE@1224|Proteobacteria,43BQE@68525|delta/epsilon subdivisions,2X71H@28221|Deltaproteobacteria,2MHKV@213118|Desulfobacterales 28221|Deltaproteobacteria CI Conserved carboxylase domain - - 4.1.1.3,6.4.1.1 ko:K01571,ko:K01960 ko00020,ko00620,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00720,map01100,map01120,map01200,map01230 M00173,M00620 R00217,R00344 RC00040,RC00367 ko00000,ko00001,ko00002,ko01000,ko02000 3.B.1.1.1 - - Biotin_lipoyl,HMGL-like,PYC_OADA k59_1296317_1 1250005.PHEL85_2846 2.17e-116 365.0 COG1038@1|root,COG1038@2|Bacteria,4NFHU@976|Bacteroidetes,1HYR4@117743|Flavobacteriia,3VW8D@52959|Polaribacter 976|Bacteroidetes C Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second cfiB - 6.4.1.1 ko:K01958 ko00020,ko00620,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00720,map01100,map01120,map01200,map01230 M00173 R00344 RC00040,RC00367 ko00000,ko00001,ko00002,ko01000 - - - Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2,HMGL-like,PYC_OADA k59_168212_2 1027273.GZ77_10270 8.51e-16 76.6 COG0615@1|root,COG0615@2|Bacteria 2|Bacteria H ADP-L-glycero-beta-D-manno-heptose biosynthetic process - - 2.7.7.39 ko:K00980 ko00564,map00564 - R00856 RC00002 ko00000,ko00001,ko01000 - - - CTP_transf_like k59_1465967_1 436308.Nmar_0201 2.42e-37 133.0 COG1032@1|root,arCOG01363@2157|Archaea,41S6P@651137|Thaumarchaeota 651137|Thaumarchaeota C Radical SAM - - - - - - - - - - - - Radical_SAM k59_449006_1 1129374.AJE_05246 1.16e-92 280.0 COG0123@1|root,COG0123@2|Bacteria,1MU7P@1224|Proteobacteria,1RN8W@1236|Gammaproteobacteria,464TQ@72275|Alteromonadaceae 1236|Gammaproteobacteria BQ COG0123 Deacetylases, including yeast histone deacetylase and acetoin utilization protein - - - - - - - - - - - - Hist_deacetyl k59_1241656_1 1285586.H131_00290 1.45e-16 85.9 COG1694@1|root,COG3956@2|Bacteria,1TPK1@1239|Firmicutes,4HA0A@91061|Bacilli,3IVQG@400634|Lysinibacillus 91061|Bacilli S MazG nucleotide pyrophosphohydrolase domain yabN GO:0003674,GO:0003824,GO:0006139,GO:0006163,GO:0006195,GO:0006203,GO:0006213,GO:0006220,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009143,GO:0009144,GO:0009146,GO:0009147,GO:0009149,GO:0009151,GO:0009155,GO:0009164,GO:0009166,GO:0009199,GO:0009200,GO:0009203,GO:0009204,GO:0009208,GO:0009210,GO:0009211,GO:0009213,GO:0009215,GO:0009217,GO:0009218,GO:0009219,GO:0009222,GO:0009223,GO:0009259,GO:0009261,GO:0009262,GO:0009264,GO:0009394,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0042454,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0046046,GO:0046047,GO:0046051,GO:0046052,GO:0046060,GO:0046061,GO:0046070,GO:0046075,GO:0046076,GO:0046080,GO:0046081,GO:0046131,GO:0046133,GO:0046135,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:0072527,GO:0072529,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1901657,GO:1901658 3.6.1.66 ko:K02428,ko:K02499 ko00230,map00230 - R00426,R00720,R01855,R02100,R02720,R03531 RC00002 ko00000,ko00001,ko01000,ko03036 - - - MazG,TP_methylase k59_225506_1 1197477.IA57_03545 2.32e-93 301.0 COG0841@1|root,COG0841@2|Bacteria,4NDZG@976|Bacteroidetes,1HX2H@117743|Flavobacteriia 976|Bacteroidetes V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_1637762_1 1125863.JAFN01000001_gene94 5.11e-116 340.0 COG0473@1|root,COG0473@2|Bacteria,1MUH4@1224|Proteobacteria,42M8G@68525|delta/epsilon subdivisions,2WIYB@28221|Deltaproteobacteria 28221|Deltaproteobacteria C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate - - 1.1.1.85 ko:K00052 ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230 M00432,M00535 R00994,R04426,R10052 RC00084,RC00417,RC03036 br01601,ko00000,ko00001,ko00002,ko01000 - - - Iso_dh k59_560205_1 1121939.L861_10420 9.37e-54 182.0 COG2017@1|root,COG2017@2|Bacteria,1MVMN@1224|Proteobacteria,1RNZN@1236|Gammaproteobacteria,1XJKW@135619|Oceanospirillales 135619|Oceanospirillales G Converts alpha-aldose to the beta-anomer galM - 5.1.3.3 ko:K01785 ko00010,ko00052,ko01100,ko01110,ko01120,ko01130,map00010,map00052,map01100,map01110,map01120,map01130 M00632 R01602,R10619 RC00563 ko00000,ko00001,ko00002,ko01000 - - - Aldose_epim k59_560205_2 743719.PaelaDRAFT_4451 4.6e-46 158.0 COG0673@1|root,COG0673@2|Bacteria,1TPT5@1239|Firmicutes,4HAPJ@91061|Bacilli,26TSR@186822|Paenibacillaceae 91061|Bacilli S Dehydrogenase ddhD - - - - - - - - - - - GFO_IDH_MocA,GFO_IDH_MocA_C k59_1802370_1 1051632.TPY_3156 2.14e-32 126.0 COG3328@1|root,COG3328@2|Bacteria,1V116@1239|Firmicutes,24D8K@186801|Clostridia 186801|Clostridia L Transposase, Mutator family - - - - - - - - - - - - Transposase_mut k59_846441_1 371731.Rsw2DRAFT_2884 6.27e-27 113.0 COG3664@1|root,COG3664@2|Bacteria 2|Bacteria G PFAM glycoside hydrolase family 39 - - - - - - - - - - - - CBM9_1,Glyco_hydro_39 k59_846444_1 232721.Ajs_4005 1.13e-87 278.0 COG0342@1|root,COG0342@2|Bacteria,1MV5U@1224|Proteobacteria,2VHKD@28216|Betaproteobacteria,4A9UJ@80864|Comamonadaceae 28216|Betaproteobacteria U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA secD - - ko:K03072 ko03060,ko03070,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 2.A.6.4,3.A.5.2,3.A.5.7 - - SecD-TM1,SecD_SecF,Sec_GG k59_846444_2 1132855.KB913035_gene700 2.31e-19 80.9 COG1862@1|root,COG1862@2|Bacteria,1MZT2@1224|Proteobacteria,2VU6T@28216|Betaproteobacteria,2KN55@206350|Nitrosomonadales 206350|Nitrosomonadales U TIGRFAM preprotein translocase, YajC subunit - - - ko:K03210 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2 - - YajC k59_1693236_1 446470.Snas_3511 3.03e-19 88.6 COG2377@1|root,COG2377@2|Bacteria,2GNAM@201174|Actinobacteria 201174|Actinobacteria O Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling anmK - 2.7.1.170 ko:K09001 - - - - ko00000,ko01000 - - - AnmK k59_846455_1 316407.85676967 1.62e-33 119.0 COG3054@1|root,COG3054@2|Bacteria,1REC3@1224|Proteobacteria,1S3X5@1236|Gammaproteobacteria,3XP2K@561|Escherichia 1236|Gammaproteobacteria S Bacterial protein of unknown function (YtfJ_HI0045) ytfJ - - ko:K07109 - - - - ko00000 - - - YtfJ_HI0045 k59_846455_2 199310.c5314 1.78e-44 148.0 COG3054@1|root,COG3054@2|Bacteria,1REC3@1224|Proteobacteria,1S3X5@1236|Gammaproteobacteria,3XP2K@561|Escherichia 1236|Gammaproteobacteria S Bacterial protein of unknown function (YtfJ_HI0045) ytfJ - - ko:K07109 - - - - ko00000 - - - YtfJ_HI0045 k59_846455_3 199310.c5315 4.73e-41 135.0 2CTIP@1|root,32STK@2|Bacteria,1MZ8V@1224|Proteobacteria,1S908@1236|Gammaproteobacteria,3XQ29@561|Escherichia 1236|Gammaproteobacteria S Protein of unknown function (DUF1107) ytfK - - - - - - - - - - - DUF1107 k59_846455_4 316407.85676969 3.49e-13 68.2 COG1253@1|root,COG1253@2|Bacteria,1MV3P@1224|Proteobacteria,1T1MS@1236|Gammaproteobacteria,3XNSD@561|Escherichia 1236|Gammaproteobacteria P inner membrane protein YtfL ytfL GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - - - - - - - - - - CBS,CorC_HlyC,DUF21 k59_846459_2 493475.GARC_0741 7.98e-08 54.7 COG1752@1|root,COG1752@2|Bacteria,1N5SK@1224|Proteobacteria,1RSDG@1236|Gammaproteobacteria,463Z8@72275|Alteromonadaceae 1236|Gammaproteobacteria S esterase of the alpha-beta hydrolase superfamily - - - ko:K07001 - - - - ko00000 - - - DUF3336,Patatin k59_846469_1 557599.MKAN_00165 2.37e-09 60.1 COG2124@1|root,COG2124@2|Bacteria,2HSPE@201174|Actinobacteria,232YX@1762|Mycobacteriaceae 201174|Actinobacteria C cytochrome P-450 cyp143 - - - - - - - - - - - p450 k59_846469_2 1282876.BAOK01000001_gene1017 1.08e-30 118.0 COG2267@1|root,COG2267@2|Bacteria,1R9GQ@1224|Proteobacteria,2U3YF@28211|Alphaproteobacteria 28211|Alphaproteobacteria I Alpha beta hydrolase - - - - - - - - - - - - Abhydrolase_6 k59_1127232_1 1379270.AUXF01000003_gene3738 1.94e-40 156.0 COG3127@1|root,COG3127@2|Bacteria,1ZT3A@142182|Gemmatimonadetes 142182|Gemmatimonadetes Q FtsX-like permease family - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_675252_1 870187.Thini_1187 1.2e-92 292.0 COG4548@1|root,COG4548@2|Bacteria,1MVBZ@1224|Proteobacteria,1RNN3@1236|Gammaproteobacteria,4608U@72273|Thiotrichales 72273|Thiotrichales P PFAM von Willebrand factor type A - - - - - - - - - - - - VWA k59_846489_1 1120948.KB903243_gene2512 9.13e-23 99.8 COG2378@1|root,COG2378@2|Bacteria,2GIZC@201174|Actinobacteria,4E1PX@85010|Pseudonocardiales 201174|Actinobacteria K transcriptional regulator - - - - - - - - - - - - HTH_11,WYL k59_957350_1 1121859.KB890739_gene2147 1.82e-36 138.0 COG2838@1|root,COG2838@2|Bacteria,4NFV1@976|Bacteroidetes,47K8A@768503|Cytophagia 976|Bacteroidetes C Monomeric isocitrate dehydrogenase icd - 1.1.1.42 ko:K00031 ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146 M00009,M00010,M00173,M00740 R00267,R00268,R01899 RC00001,RC00084,RC00114,RC00626,RC02801 br01601,ko00000,ko00001,ko00002,ko01000 - - - IDH k59_957350_2 338969.Rfer_4072 2.85e-72 222.0 COG4635@1|root,COG4635@2|Bacteria,1RAH2@1224|Proteobacteria,2VSTC@28216|Betaproteobacteria,4AHVS@80864|Comamonadaceae 28216|Betaproteobacteria CH Flavodoxin domain - - 1.3.5.3 ko:K00230 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R09489 RC00885 ko00000,ko00001,ko00002,ko01000 - - - Flavodoxin_5 k59_1127272_1 251221.35214780 2.42e-08 57.8 COG0616@1|root,COG0616@2|Bacteria,1G1AY@1117|Cyanobacteria 1117|Cyanobacteria OU signal peptide peptidase SppA, 36K type sppA - - ko:K04773 - - - - ko00000,ko01000,ko01002 - - - Peptidase_S49 k59_1012785_1 765912.Thimo_1441 4.39e-64 207.0 COG2267@1|root,COG2267@2|Bacteria 2|Bacteria I carboxylic ester hydrolase activity - - 3.4.11.5 ko:K01259 ko00330,map00330 - R00135 - ko00000,ko00001,ko01000,ko01002 - - - Abhydrolase_1,Abhydrolase_6,Hydrolase_4 k59_957354_1 1122137.AQXF01000002_gene179 6.5e-74 233.0 COG3852@1|root,COG3852@2|Bacteria,1MVN6@1224|Proteobacteria,2TQS1@28211|Alphaproteobacteria 28211|Alphaproteobacteria T Signal transduction histidine kinase, nitrogen specific ntrB - 2.7.13.3 ko:K07708 ko02020,map02020 M00497 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA,PAS,PAS_4 k59_168307_1 436308.Nmar_1367 4.76e-51 175.0 arCOG08650@1|root,arCOG08650@2157|Archaea,41SZ5@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1296402_1 1158292.JPOE01000005_gene1315 6.19e-79 239.0 COG0450@1|root,COG0450@2|Bacteria,1MX2B@1224|Proteobacteria,2VK8F@28216|Betaproteobacteria 28216|Betaproteobacteria O PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen - - 1.11.1.15 ko:K03386 ko04214,map04214 - - - ko00000,ko00001,ko01000,ko04147 - - - 1-cysPrx_C,AhpC-TSA k59_1296407_1 1095769.CAHF01000011_gene2128 2.1e-79 256.0 COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,2VH0Y@28216|Betaproteobacteria,473M2@75682|Oxalobacteraceae 28216|Betaproteobacteria I 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain fadB2 - 1.1.1.35,4.2.1.17,5.1.2.3 ko:K01782 ko00071,ko00280,ko00281,ko00310,ko00362,ko00380,ko00410,ko00640,ko00650,ko00903,ko00930,ko01040,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00362,map00380,map00410,map00640,map00650,map00903,map00930,map01040,map01100,map01110,map01120,map01130,map01200,map01212 M00032,M00087 R01975,R03026,R03045,R03276,R04137,R04170,R04203,R04204,R04224,R04737,R04738,R04739,R04740,R04741,R04744,R04745,R04746,R04748,R04749,R05066,R05305,R06411,R06412,R06941,R06942,R07935,R07951,R08093,R08094 RC00029,RC00099,RC00117,RC00241,RC00525,RC00831,RC00834,RC00896,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 - - - 3HCDH,3HCDH_N,ECH_1 k59_1466045_1 643473.KB235931_gene4778 1.04e-34 132.0 COG1104@1|root,COG1104@2|Bacteria,1G0D5@1117|Cyanobacteria,1HK2K@1161|Nostocales 1117|Cyanobacteria E Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine nifS - 2.8.1.7 ko:K04487 ko00730,ko01100,ko04122,map00730,map01100,map04122 - R07460,R11528,R11529 RC01789,RC02313 ko00000,ko00001,ko01000,ko02048,ko03016,ko03029 - - - Aminotran_5 k59_1466045_2 316057.RPD_1070 4.52e-31 110.0 COG5554@1|root,COG5554@2|Bacteria,1N7DQ@1224|Proteobacteria,2UF73@28211|Alphaproteobacteria,3K06X@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria Q NifT/FixU protein fixU - - ko:K02593 - - - - ko00000 - - - NifT k59_957366_2 1144275.COCOR_07086 3.59e-06 52.4 COG0810@1|root,COG0810@2|Bacteria,1NFMG@1224|Proteobacteria,42UAW@68525|delta/epsilon subdivisions,2WTBZ@28221|Deltaproteobacteria,2Z1UD@29|Myxococcales 28221|Deltaproteobacteria M Ferric siderophore transporter, periplasmic energy transduction protein TonB - - - ko:K03832 - - - - ko00000,ko02000 2.C.1.1 - - TonB_C k59_560278_1 1121921.KB898711_gene1919 1.92e-102 333.0 COG1197@1|root,COG1197@2|Bacteria,1MUXG@1224|Proteobacteria,1RNCU@1236|Gammaproteobacteria,2PMXA@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria L TRCF mfd GO:0000715,GO:0000716,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006283,GO:0006289,GO:0006355,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008094,GO:0008150,GO:0008152,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0015616,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019219,GO:0019222,GO:0019899,GO:0031323,GO:0031326,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0043175,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0051276,GO:0051716,GO:0060255,GO:0065007,GO:0070063,GO:0071704,GO:0071840,GO:0080090,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1903506,GO:2000112,GO:2001141 - ko:K03723 ko03420,map03420 - - - ko00000,ko00001,ko01000,ko03400 - - - CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF k59_1750065_1 436308.Nmar_0632 2.94e-29 105.0 arCOG08753@1|root,arCOG08753@2157|Archaea,41T9W@651137|Thaumarchaeota 651137|Thaumarchaeota C 4 iron, 4 sulfur cluster binding - - - - - - - - - - - - - k59_1750067_1 1280946.HY29_04005 1.04e-18 90.9 COG1629@1|root,COG1629@2|Bacteria,COG4771@2|Bacteria,1MU9K@1224|Proteobacteria,2TTUW@28211|Alphaproteobacteria,43WD3@69657|Hyphomonadaceae 28211|Alphaproteobacteria P COG1629 Outer membrane receptor proteins, mostly Fe transport - - - - - - - - - - - - Plug,TonB_dep_Rec k59_846523_1 330214.NIDE3182 9.19e-68 220.0 COG0205@1|root,COG0205@2|Bacteria,3J0Y1@40117|Nitrospirae 40117|Nitrospirae H Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions - - 2.7.1.11,2.7.1.90 ko:K21071 ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130 - R00756,R00764,R02073,R03236,R04779 RC00002,RC00017 ko00000,ko00001,ko01000 - - - PFK k59_1185681_1 1229909.NSED_07860 1.99e-198 563.0 arCOG06613@1|root,arCOG06613@2157|Archaea,41T0Z@651137|Thaumarchaeota 651137|Thaumarchaeota V AIPR protein - - - - - - - - - - - - AIPR k59_225593_1 1123070.KB899247_gene1632 9.06e-96 291.0 COG2805@1|root,COG2805@2|Bacteria,46SY2@74201|Verrucomicrobia,2ITP5@203494|Verrucomicrobiae 203494|Verrucomicrobiae NU Type II/IV secretion system protein - - - ko:K02669 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE k59_846525_1 344747.PM8797T_31985 1.45e-69 238.0 COG0553@1|root,COG0553@2|Bacteria,2IXFX@203682|Planctomycetes 203682|Planctomycetes L COG0553 Superfamily II DNA RNA - - - - - - - - - - - - Helicase_C,SNF2_N,SWIM k59_504386_2 1211114.ALIP01000052_gene40 5.33e-156 469.0 COG0458@1|root,COG0458@2|Bacteria,1MUDZ@1224|Proteobacteria,1RPIU@1236|Gammaproteobacteria,1X3MZ@135614|Xanthomonadales 135614|Xanthomonadales F Four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate carB GO:0000050,GO:0003674,GO:0003824,GO:0004087,GO:0004088,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016884,GO:0019627,GO:0019752,GO:0034641,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 6.3.5.5 ko:K01955 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - - CPSase_L_D2,CPSase_L_D3,MGS k59_1802461_1 1279017.AQYJ01000026_gene55 1.49e-147 441.0 COG1049@1|root,COG1049@2|Bacteria,1MVCR@1224|Proteobacteria,1RNMC@1236|Gammaproteobacteria,46445@72275|Alteromonadaceae 1236|Gammaproteobacteria C Belongs to the aconitase IPM isomerase family acnB - 4.2.1.3,4.2.1.99 ko:K01682 ko00020,ko00630,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00173 R01324,R01325,R01900,R04425 RC00497,RC00498,RC00618,RC01153 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase,Aconitase_2_N,Aconitase_B_N k59_1750078_1 107635.AZUO01000001_gene1608 1.73e-35 124.0 COG2146@1|root,COG2146@2|Bacteria,1RJ31@1224|Proteobacteria,2UA0N@28211|Alphaproteobacteria,3709W@31993|Methylocystaceae 28211|Alphaproteobacteria P Rieske [2Fe-2S] domain - - - ko:K15762 ko00623,ko00920,ko01100,ko01120,ko01220,map00623,map00920,map01100,map01120,map01220 M00538 R02550,R03562,R05666,R09513 RC00269,RC00490,RC02556 ko00000,ko00001,ko00002 - - - Rieske k59_846535_1 436308.Nmar_0881 1.59e-50 165.0 COG1651@1|root,arCOG02868@2157|Archaea,41T2W@651137|Thaumarchaeota 651137|Thaumarchaeota O DSBA-like thioredoxin domain - - - - - - - - - - - - Thioredoxin_4 k59_846535_2 436308.Nmar_0882 1.57e-65 211.0 COG1503@1|root,arCOG01742@2157|Archaea,41SEK@651137|Thaumarchaeota 651137|Thaumarchaeota J Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA prf1 - - ko:K03265 ko03015,map03015 - - - ko00000,ko00001,ko03012,ko03019 - - - eRF1_1,eRF1_2,eRF1_3 k59_168360_1 349521.HCH_01753 3.77e-23 103.0 COG0427@1|root,COG0427@2|Bacteria,1PJY0@1224|Proteobacteria,1RPS6@1236|Gammaproteobacteria,1XKCF@135619|Oceanospirillales 135619|Oceanospirillales C Acetyl-CoA hydrolase - - - - - - - - - - - - AcetylCoA_hyd_C,AcetylCoA_hydro k59_1637874_1 745411.B3C1_12824 9.33e-46 170.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria 1236|Gammaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K03296 - - - - ko00000 2.A.6.2 - - ACR_tran k59_1637876_1 382245.ASA_3146 3.98e-52 171.0 COG0164@1|root,COG0164@2|Bacteria,1RA65@1224|Proteobacteria,1RQ4B@1236|Gammaproteobacteria,1Y48S@135624|Aeromonadales 135624|Aeromonadales L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids rnhB - 3.1.26.4 ko:K03470 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - RNase_HII k59_846544_1 1545915.JROG01000004_gene2187 2.15e-55 185.0 COG1804@1|root,COG1804@2|Bacteria,1NSWZ@1224|Proteobacteria,2U2UE@28211|Alphaproteobacteria,2K9MU@204457|Sphingomonadales 204457|Sphingomonadales C CoA-transferase family III - - - - - - - - - - - - CoA_transf_3 k59_957404_1 631454.N177_3726 1.25e-55 194.0 COG0296@1|root,COG0296@2|Bacteria,1QTVN@1224|Proteobacteria,2TR5K@28211|Alphaproteobacteria,1JN9I@119043|Rhodobiaceae 28211|Alphaproteobacteria G Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position glgB - 2.4.1.18 ko:K00700 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R02110 - ko00000,ko00001,ko00002,ko01000,ko04147 - CBM48,GH13 - Alpha-amylase,Alpha-amylase_C,CBM_48 k59_846545_2 1415778.JQMM01000001_gene1831 9.93e-13 65.9 COG3767@1|root,COG3767@2|Bacteria,1N9HK@1224|Proteobacteria,1SD4Q@1236|Gammaproteobacteria,1J6WQ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_1637885_1 1122137.AQXF01000002_gene409 4.58e-143 427.0 COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TQQ9@28211|Alphaproteobacteria 28211|Alphaproteobacteria T Histidine kinase cckA - 2.7.13.3 ko:K13587 ko02020,ko04112,map02020,map04112 M00512 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA,PAS,PAS_4,PAS_8,PAS_9,Response_reg k59_1466110_1 436308.Nmar_0911 9.69e-40 143.0 COG0147@1|root,arCOG02014@2157|Archaea,41S8W@651137|Thaumarchaeota 651137|Thaumarchaeota E component I - - 4.1.3.27 ko:K01657 ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025 M00023 R00985,R00986 RC00010,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 - - - Anth_synt_I_N,Chorismate_bind k59_1702371_1 565045.NOR51B_1645 1.67e-100 309.0 COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,1NBSJ@1224|Proteobacteria,1S0WV@1236|Gammaproteobacteria,1J5KF@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Pyruvate ferredoxin oxidoreductase and related 2-oxoacid ferredoxin oxidoreductases korA - 1.2.7.11,1.2.7.3 ko:K00174 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - PFOR_II,POR,POR_N k59_459761_1 1122137.AQXF01000003_gene2366 2.3e-200 566.0 COG0644@1|root,COG2440@1|root,COG0644@2|Bacteria,COG2440@2|Bacteria,1MVU6@1224|Proteobacteria,2TS0R@28211|Alphaproteobacteria 28211|Alphaproteobacteria C electron transfer flavoprotein-ubiquinone oxidoreductase etf - 1.5.5.1 ko:K00311 - - - - ko00000,ko01000 - - - ETF_QO,FAD_binding_2,NAD_binding_8 k59_1025479_1 314287.GB2207_11003 4.46e-23 102.0 COG0810@1|root,COG0810@2|Bacteria,1PEER@1224|Proteobacteria,1RPPU@1236|Gammaproteobacteria,1J7A9@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M COG0810 Periplasmic protein TonB, links inner and outer membranes - - - ko:K03832 - - - - ko00000,ko02000 2.C.1.1 - - Chalcone_3,TonB_2,TonB_C k59_121171_1 1122137.AQXF01000006_gene944 1.67e-108 324.0 COG2256@1|root,COG2256@2|Bacteria,1MUVS@1224|Proteobacteria,2TQVF@28211|Alphaproteobacteria 28211|Alphaproteobacteria L COG2256 ATPase related to the helicase subunit of the Holliday junction resolvase - - - ko:K07478 - - - - ko00000 - - - AAA,AAA_assoc_2,MgsA_C,RuvB_N k59_515795_2 545694.TREPR_2255 7.5e-77 261.0 COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,2J5JP@203691|Spirochaetes 203691|Spirochaetes G Belongs to the PEP-utilizing enzyme family ppdK - 2.7.9.1 ko:K01006 ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200 M00169,M00171,M00172,M00173 R00206 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - PEP-utilizers,PEP-utilizers_C,PPDK_N k59_8220_1 279714.FuraDRAFT_3745 2.68e-13 75.9 COG3899@1|root,COG5001@1|root,COG3899@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria 1224|Proteobacteria T Diguanylate cyclase - - - - - - - - - - - - AAA_16,CHASE8,EAL,GAF,GGDEF,PAS_9,Pkinase k59_121172_1 1096930.L284_07405 2.86e-136 389.0 COG1136@1|root,COG1136@2|Bacteria,1MVSQ@1224|Proteobacteria,2TSBE@28211|Alphaproteobacteria,2K04P@204457|Sphingomonadales 204457|Sphingomonadales V Part of the ABC transporter complex LolCDE involved in the translocation of lipoproteins, in an ATP-dependent manner lolD - - ko:K09810 ko02010,map02010 M00255 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.125 - - ABC_tran k59_121172_2 1219045.BV98_003530 2.9e-34 127.0 COG4591@1|root,COG4591@2|Bacteria,1MVV7@1224|Proteobacteria,2TRBX@28211|Alphaproteobacteria,2K03V@204457|Sphingomonadales 204457|Sphingomonadales M ABC-type transport system, involved in lipoprotein release, permease component - - - ko:K09808 ko02010,map02010 M00255 - - ko00000,ko00001,ko00002,ko02000 3.A.1.125 - - FtsX,MacB_PCD k59_1533385_1 1123367.C666_10860 5.99e-17 72.8 COG2835@1|root,COG2835@2|Bacteria,1N6Y2@1224|Proteobacteria,2VW58@28216|Betaproteobacteria,2KXCI@206389|Rhodocyclales 206389|Rhodocyclales S Belongs to the UPF0434 family - - - ko:K09791 - - - - ko00000 - - - Trm112p k59_1533385_2 1123279.ATUS01000004_gene2920 1.48e-29 116.0 COG1663@1|root,COG1663@2|Bacteria,1MU8G@1224|Proteobacteria,1RMMW@1236|Gammaproteobacteria,1J5MP@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria F Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) lpxK GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0005976,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0008654,GO:0009029,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019637,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044464,GO:0046401,GO:0046467,GO:0046493,GO:0071704,GO:0071944,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 2.7.1.130 ko:K00912 ko00540,ko01100,map00540,map01100 M00060 R04657 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000,ko01005 - - iBWG_1329.BWG_0767,iECDH10B_1368.ECDH10B_0985,iPC815.YPO1396 LpxK k59_911949_1 1415778.JQMM01000001_gene1955 2.17e-57 189.0 COG0705@1|root,COG0705@2|Bacteria,1MYPM@1224|Proteobacteria,1RN1K@1236|Gammaproteobacteria,1J6AI@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S membrane protein (homolog of Drosophila rhomboid) glpG GO:0000976,GO:0000984,GO:0000986,GO:0000987,GO:0001017,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003824,GO:0004175,GO:0004252,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006355,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016020,GO:0016021,GO:0016787,GO:0017171,GO:0019219,GO:0019222,GO:0019538,GO:0031224,GO:0031226,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0042802,GO:0043170,GO:0043565,GO:0044212,GO:0044238,GO:0044425,GO:0044459,GO:0044464,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0070011,GO:0071704,GO:0071944,GO:0080090,GO:0097159,GO:0140096,GO:1901363,GO:1901564,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2001141 - ko:K02441 - - - - ko00000 - - - NRho,Rhomboid,Rhomboid_N k59_1589379_1 1218074.BAXZ01000020_gene3945 5.62e-104 309.0 COG0540@1|root,COG0540@2|Bacteria,1MWAB@1224|Proteobacteria,2VHG9@28216|Betaproteobacteria,1JZN1@119060|Burkholderiaceae 28216|Betaproteobacteria F Belongs to the ATCase OTCase family pyrB - 2.1.3.2 ko:K00609 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R01397 RC00064,RC02850 ko00000,ko00001,ko00002,ko01000 - - - OTCace,OTCace_N k59_1081228_1 1278073.MYSTI_01350 5.3e-20 89.7 2ARAZ@1|root,31GKZ@2|Bacteria,1NPW3@1224|Proteobacteria,43320@68525|delta/epsilon subdivisions,2WY42@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Domain of unknown function (DUF3332) - - - - - - - - - - - - DUF3332 k59_911966_1 1396418.BATQ01000170_gene2643 1.74e-27 110.0 COG1226@1|root,COG1226@2|Bacteria,46Z52@74201|Verrucomicrobia,2IUBN@203494|Verrucomicrobiae 203494|Verrucomicrobiae P Ion transport protein - - - - - - - - - - - - Ion_trans k59_911966_2 748247.AZKH_2871 1.67e-50 165.0 COG1633@1|root,COG1633@2|Bacteria,1RJFW@1224|Proteobacteria,2VT5X@28216|Betaproteobacteria,2KWJT@206389|Rhodocyclales 206389|Rhodocyclales S Rubrerythrin - - - - - - - - - - - - Rubrerythrin k59_1419897_1 316407.4062541 8.36e-134 399.0 COG0489@1|root,COG3206@1|root,COG0489@2|Bacteria,COG3206@2|Bacteria,1MVI9@1224|Proteobacteria,1RNB0@1236|Gammaproteobacteria,3XN7H@561|Escherichia 1236|Gammaproteobacteria DM Tyrosine-protein kinase wzc GO:0000271,GO:0003674,GO:0003824,GO:0004672,GO:0004713,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0005975,GO:0005976,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009242,GO:0009987,GO:0016020,GO:0016021,GO:0016051,GO:0016301,GO:0016310,GO:0016462,GO:0016740,GO:0016772,GO:0016773,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0018108,GO:0018193,GO:0018212,GO:0019538,GO:0031224,GO:0031226,GO:0033692,GO:0034637,GO:0034645,GO:0036211,GO:0038083,GO:0042802,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0046377,GO:0046777,GO:0071704,GO:0071944,GO:0140096,GO:1901135,GO:1901137,GO:1901564,GO:1901576 - ko:K16692 - - - - ko00000,ko01000,ko01001 - - - AAA_31,GNVR,Wzz k59_742433_1 88036.EFJ36990 7.59e-73 233.0 COG0626@1|root,KOG0053@2759|Eukaryota,37RGY@33090|Viridiplantae,3GB43@35493|Streptophyta 35493|Streptophyta E methionine MGL GO:0000096,GO:0000097,GO:0000098,GO:0001101,GO:0003674,GO:0003824,GO:0003962,GO:0004123,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006534,GO:0006555,GO:0006790,GO:0006807,GO:0006950,GO:0007154,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009056,GO:0009058,GO:0009063,GO:0009066,GO:0009067,GO:0009068,GO:0009069,GO:0009070,GO:0009086,GO:0009087,GO:0009092,GO:0009267,GO:0009414,GO:0009415,GO:0009605,GO:0009628,GO:0009970,GO:0009987,GO:0009991,GO:0010035,GO:0016043,GO:0016053,GO:0016054,GO:0016740,GO:0016765,GO:0016829,GO:0016846,GO:0017144,GO:0018826,GO:0019343,GO:0019344,GO:0019346,GO:0019458,GO:0019752,GO:0019842,GO:0022607,GO:0030170,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0036094,GO:0042221,GO:0042594,GO:0042631,GO:0043167,GO:0043168,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044272,GO:0044273,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046395,GO:0048037,GO:0050662,GO:0050667,GO:0050896,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0051716,GO:0065003,GO:0070279,GO:0070887,GO:0071214,GO:0071229,GO:0071265,GO:0071266,GO:0071462,GO:0071496,GO:0071704,GO:0071840,GO:0097159,GO:0104004,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1901607,GO:1901700,GO:1901701 4.4.1.11 ko:K01761 ko00270,ko00450,map00270,map00450 - R00654,R04770 RC00196,RC00348,RC01209,RC01210 ko00000,ko00001,ko01000 - - - Cys_Met_Meta_PP k59_65001_2 1117318.PRUB_13796 1.56e-53 172.0 COG4067@1|root,COG4067@2|Bacteria,1RGX8@1224|Proteobacteria,1S5YR@1236|Gammaproteobacteria,2Q2GU@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria O protein conserved in archaea - - - - - - - - - - - - Zn_protease k59_65002_1 316407.1799622 7.59e-130 378.0 COG1169@1|root,COG1169@2|Bacteria,1MVB7@1224|Proteobacteria,1RNSR@1236|Gammaproteobacteria,3XPGQ@561|Escherichia 1236|Gammaproteobacteria H Catalyzes the conversion of chorismate to isochorismate menF GO:0000162,GO:0000287,GO:0003674,GO:0003824,GO:0004049,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005950,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006732,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008909,GO:0009058,GO:0009072,GO:0009073,GO:0009108,GO:0009233,GO:0009234,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016829,GO:0016830,GO:0016833,GO:0016853,GO:0016866,GO:0018130,GO:0019438,GO:0019752,GO:0032991,GO:0034641,GO:0042180,GO:0042181,GO:0042401,GO:0042430,GO:0042435,GO:0043167,GO:0043169,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0046872,GO:0050486,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1901661,GO:1901663,GO:1902494 5.4.4.2 ko:K01851,ko:K02361,ko:K02552 ko00130,ko01053,ko01100,ko01110,ko01130,map00130,map01053,map01100,map01110,map01130 M00116 R01717 RC00588 ko00000,ko00001,ko00002,ko01000 - - iECABU_c1320.ECABU_c26010,iECIAI39_1322.ECIAI39_2413,iSF_1195.SF2344,iS_1188.S2478,ic_1306.c2809 Chorismate_bind k59_177230_1 377629.TERTU_3437 3.57e-33 122.0 arCOG03638@1|root,2Z7NN@2|Bacteria,1R3Y6@1224|Proteobacteria,1RTWY@1236|Gammaproteobacteria,2PPR1@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria S Protein of unknown function (DUF1538) - - - - - - - - - - - - DUF1538 k59_1477112_1 1122137.AQXF01000005_gene1083 7.6e-16 72.8 COG0386@1|root,COG0386@2|Bacteria,1RD1R@1224|Proteobacteria,2U7R3@28211|Alphaproteobacteria 28211|Alphaproteobacteria O Belongs to the glutathione peroxidase family MA20_01100 - 1.11.1.9 ko:K00432 ko00480,ko00590,ko04918,map00480,map00590,map04918 - R00274,R07034,R07035 RC00011,RC00982 ko00000,ko00001,ko01000 - - - GSHPx k59_1477112_2 565045.NOR51B_2835 4.57e-37 140.0 COG1231@1|root,COG1231@2|Bacteria,1QXX6@1224|Proteobacteria,1T3IZ@1236|Gammaproteobacteria 1236|Gammaproteobacteria E K COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit - - 1.5.99.6 ko:K00316 ko00330,ko00410,ko01100,map00330,map00410,map01100 - R01914,R01915 RC00053,RC00225 ko00000,ko00001,ko01000 - - - NAD_binding_8 k59_121220_1 1206729.BAFZ01000061_gene3850 0.00025 49.7 COG0574@1|root,COG3848@1|root,COG0574@2|Bacteria,COG3848@2|Bacteria,2GK73@201174|Actinobacteria,4FVX8@85025|Nocardiaceae 201174|Actinobacteria G PEP-utilising enzyme, mobile domain - - 2.7.9.1 ko:K01006 ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200 M00169,M00171,M00172,M00173 R00206 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - PEP-utilizers,PPDK_N k59_799480_1 1219035.NT2_04_02900 1.76e-28 111.0 COG2972@1|root,COG2972@2|Bacteria,1MXVQ@1224|Proteobacteria,2U16F@28211|Alphaproteobacteria,2JZWJ@204457|Sphingomonadales 204457|Sphingomonadales T Histidine kinase - - - - - - - - - - - - HATPase_c,His_kinase k59_799480_2 981384.AEYW01000001_gene1524 6.99e-18 82.4 COG1651@1|root,COG1651@2|Bacteria,1MY3H@1224|Proteobacteria,2TTXR@28211|Alphaproteobacteria,4NCZS@97050|Ruegeria 28211|Alphaproteobacteria O Thioredoxin bdbD_2 - - - - - - - - - - - DSBA,Thioredoxin_4 k59_572579_1 203122.Sde_0953 1.18e-116 349.0 COG5434@1|root,COG5434@2|Bacteria,1MXP8@1224|Proteobacteria,1RRJZ@1236|Gammaproteobacteria,4644J@72275|Alteromonadaceae 1236|Gammaproteobacteria G Belongs to the glycosyl hydrolase 28 family - - - - - - - - - - - - Glyco_hydro_28,Pectate_lyase_3 k59_459799_1 1122236.KB905142_gene402 9.53e-32 124.0 COG1251@1|root,COG1251@2|Bacteria,1MW58@1224|Proteobacteria,2VN2R@28216|Betaproteobacteria,2KP5I@206350|Nitrosomonadales 206350|Nitrosomonadales C Nitrite and sulphite reductase 4Fe-4S domain - - 1.7.1.15 ko:K00362 ko00910,ko01120,map00910,map01120 M00530 R00787 RC00176 ko00000,ko00001,ko00002,ko01000 - - - Fer2_BFD,NIR_SIR,NIR_SIR_ferr,Pyr_redox_2 k59_459799_2 1437824.BN940_18211 7.49e-13 67.0 COG2146@1|root,COG2146@2|Bacteria,1MZBY@1224|Proteobacteria,2VSF0@28216|Betaproteobacteria,3T4UI@506|Alcaligenaceae 28216|Betaproteobacteria P COG2146 Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases nirD - 1.7.1.15 ko:K00363 ko00910,ko01120,map00910,map01120 M00530 R00787 RC00176 ko00000,ko00001,ko00002,ko01000 - - - Rieske_2 k59_1533439_1 335659.S23_46020 1.15e-37 134.0 COG1348@1|root,COG1348@2|Bacteria,1MVTE@1224|Proteobacteria,2TSKC@28211|Alphaproteobacteria,3JQXH@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria P The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components the iron protein and the molybdenum-iron protein nifH - 1.18.6.1 ko:K02588 ko00625,ko00910,ko01100,ko01120,map00625,map00910,map01100,map01120 M00175 R05185,R05496 RC00002,RC01395,RC02891 ko00000,ko00001,ko00002,ko01000 - - - Fer4_NifH k59_1533439_2 622637.KE124774_gene3639 1.57e-19 87.4 COG2710@1|root,COG2710@2|Bacteria,1MVY2@1224|Proteobacteria,2TU8M@28211|Alphaproteobacteria,36ZIG@31993|Methylocystaceae 28211|Alphaproteobacteria C Nitrogenase component 1 type Oxidoreductase nifD - 1.18.6.1 ko:K02586 ko00625,ko00910,ko01100,ko01120,map00625,map00910,map01100,map01120 M00175 R05185,R05496 RC00002,RC01395,RC02891 ko00000,ko00001,ko00002,ko01000 - - - Oxidored_nitro k59_177258_1 1114964.L485_21320 4.43e-20 96.3 COG2211@1|root,COG2211@2|Bacteria,1MVUM@1224|Proteobacteria,2U1DI@28211|Alphaproteobacteria,2K2D8@204457|Sphingomonadales 204457|Sphingomonadales G MFS/sugar transport protein - - - - - - - - - - - - MFS_2 k59_1137624_1 436308.Nmar_0559 1.25e-05 50.4 arCOG08027@1|root,arCOG08027@2157|Archaea,41T8U@651137|Thaumarchaeota 651137|Thaumarchaeota D Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity - - - - - - - - - - - - - k59_1137624_2 1229909.NSED_02830 5.96e-38 130.0 COG1225@1|root,arCOG00310@2157|Archaea,41SN5@651137|Thaumarchaeota 651137|Thaumarchaeota O AhpC/TSA antioxidant enzyme - - 1.11.1.15 ko:K03564 - - - - ko00000,ko01000 - - - AhpC-TSA k59_65009_1 1229909.NSED_02750 2.11e-169 483.0 COG0422@1|root,arCOG02741@2157|Archaea,41S5Z@651137|Thaumarchaeota 651137|Thaumarchaeota H Thiamine biosynthesis protein ThiC - - 4.1.99.17 ko:K03147 ko00730,ko01100,map00730,map01100 M00127 R03472 RC03251,RC03252 ko00000,ko00001,ko00002,ko01000 - - - ThiC_Rad_SAM k59_1759129_1 396588.Tgr7_0025 2.78e-92 279.0 COG0543@1|root,COG0633@1|root,COG0543@2|Bacteria,COG0633@2|Bacteria,1MV72@1224|Proteobacteria,1RPH5@1236|Gammaproteobacteria,1WXHI@135613|Chromatiales 135613|Chromatiales C Oxidoreductase FAD-binding domain - - 1.17.1.1 ko:K00523 ko00520,map00520 - R03391,R03392 RC00230 ko00000,ko00001,ko01000 - - - FAD_binding_6,Fer2,NAD_binding_1 k59_65012_1 1035191.HMPREF0185_02396 3.09e-07 56.6 COG4249@1|root,COG4249@2|Bacteria 2|Bacteria S B-1 B cell differentiation - - - - - - - - - - - - Peptidase_C13 k59_1250835_1 702113.PP1Y_AT20259 2.33e-36 133.0 COG1835@1|root,COG1835@2|Bacteria,1R4CU@1224|Proteobacteria,2U2AF@28211|Alphaproteobacteria,2K116@204457|Sphingomonadales 204457|Sphingomonadales I Acyltransferase family - - - - - - - - - - - - Acyl_transf_3 k59_912014_1 1227352.C173_04251 2.31e-09 60.1 COG0322@1|root,COG0322@2|Bacteria,1VY8I@1239|Firmicutes,4HXHJ@91061|Bacilli,26UV1@186822|Paenibacillaceae 91061|Bacilli L GIY-YIG type nucleases (URI domain) - - - ko:K03703 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - GIY-YIG,UVR k59_912014_2 586413.CCDL010000001_gene1647 7.9e-08 56.6 COG0556@1|root,COG0556@2|Bacteria,1TPKB@1239|Firmicutes,4HB81@91061|Bacilli,23IJ4@182709|Oceanobacillus 91061|Bacilli L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage uvrB - - ko:K03702 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - Helicase_C,ResIII,UVR,UvrB k59_855821_1 1248917.ANFX01000037_gene2024 5.87e-19 84.3 COG0040@1|root,COG0040@2|Bacteria,1MUCY@1224|Proteobacteria,2TT0H@28211|Alphaproteobacteria,2K1K3@204457|Sphingomonadales 204457|Sphingomonadales E Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity hisG - 2.4.2.17 ko:K00765 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R01071 RC02819,RC03200 ko00000,ko00001,ko00002,ko01000 - - - HisG k59_855821_2 1044.EH31_07360 2.78e-23 99.0 COG4427@1|root,COG4427@2|Bacteria,1R4EV@1224|Proteobacteria,2TRVP@28211|Alphaproteobacteria,2K05T@204457|Sphingomonadales 204457|Sphingomonadales S Uncharacterized protein conserved in bacteria (DUF2332) - - - - - - - - - - - - DUF2332 k59_912016_1 1123269.NX02_18890 2.84e-71 236.0 COG4772@1|root,COG4772@2|Bacteria,1QVGF@1224|Proteobacteria,2TZ3E@28211|Alphaproteobacteria,2KEQR@204457|Sphingomonadales 204457|Sphingomonadales P TonB dependent receptor - - - - - - - - - - - - TonB_dep_Rec k59_290845_1 1235794.C811_01007 5.12e-79 244.0 COG0090@1|root,COG0090@2|Bacteria,2GK7R@201174|Actinobacteria,4CUAA@84998|Coriobacteriia 84998|Coriobacteriia J One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity rplB - - ko:K02886 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L2,Ribosomal_L2_C k59_290845_2 1385521.N803_03485 2.41e-24 94.7 COG0089@1|root,COG0089@2|Bacteria,2IQ7V@201174|Actinobacteria,4FGWM@85021|Intrasporangiaceae 201174|Actinobacteria J One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome rplW GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02892 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L23 k59_1702455_1 1163409.UUA_13380 3.61e-69 240.0 COG3209@1|root,COG4733@1|root,COG3209@2|Bacteria,COG4733@2|Bacteria,1MVV1@1224|Proteobacteria,1RP75@1236|Gammaproteobacteria,1X54E@135614|Xanthomonadales 135614|Xanthomonadales M rhs family - - - - - - - - - - - - RHS_repeat k59_65021_1 1280950.HJO_13881 3.01e-17 80.5 COG1957@1|root,COG1957@2|Bacteria,1MUIW@1224|Proteobacteria,2TSXQ@28211|Alphaproteobacteria,43XGJ@69657|Hyphomonadaceae 28211|Alphaproteobacteria F COG1957 Inosine-uridine nucleoside N-ribohydrolase - - 3.2.2.1 ko:K01239,ko:K01250 ko00230,ko00760,ko01100,map00230,map00760,map01100 - R01245,R01273,R01677,R01770,R02143 RC00033,RC00063,RC00122,RC00318,RC00485 ko00000,ko00001,ko01000 - - - IU_nuc_hydro k59_65021_2 757424.Hsero_2297 5.03e-19 89.4 COG0524@1|root,COG0524@2|Bacteria,1MV5B@1224|Proteobacteria,2VR36@28216|Betaproteobacteria,4731Y@75682|Oxalobacteraceae 28216|Betaproteobacteria G Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway rbsK - 2.7.1.15 ko:K00852 ko00030,map00030 - R01051,R02750 RC00002,RC00017 ko00000,ko00001,ko01000 - - - PfkB k59_65026_1 1207055.C100_10850 3.99e-50 170.0 COG0583@1|root,COG0583@2|Bacteria,1MWY0@1224|Proteobacteria,2TSD9@28211|Alphaproteobacteria,2K2ZE@204457|Sphingomonadales 204457|Sphingomonadales K LysR family - - - - - - - - - - - - HTH_1,LysR_substrate k59_8339_1 198628.Dda3937_02283 1.35e-29 117.0 COG2357@1|root,COG2357@2|Bacteria,1RBSQ@1224|Proteobacteria,1RR52@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Region found in RelA / SpoT proteins - - - - - - - - - - - - RelA_SpoT k59_1533475_1 279238.Saro_1727 3.68e-78 263.0 COG3250@1|root,COG3250@2|Bacteria,1P9KJ@1224|Proteobacteria,2TV5M@28211|Alphaproteobacteria,2K34U@204457|Sphingomonadales 204457|Sphingomonadales G alpha-L-rhamnosidase - - - - - - - - - - - - Glyco_hydro_106 k59_855861_1 929712.KI912613_gene4198 9.1e-69 219.0 COG0552@1|root,COG0552@2|Bacteria,2GJQH@201174|Actinobacteria,4CPF9@84995|Rubrobacteria 84995|Rubrobacteria U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) ftsY - - ko:K03110 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2,3.A.5.7 - - SRP54,SRP54_N k59_855861_2 984962.XP_009548897.1 2.21e-21 90.5 COG0295@1|root,KOG0833@2759|Eukaryota,3A5YV@33154|Opisthokonta,3P5BF@4751|Fungi,3V1PH@5204|Basidiomycota,229D2@155619|Agaricomycetes,3H57J@355688|Agaricomycetes incertae sedis 4751|Fungi F This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis - GO:0003674,GO:0003824,GO:0004126,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005829,GO:0006139,GO:0006206,GO:0006213,GO:0006216,GO:0006217,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008655,GO:0009056,GO:0009058,GO:0009112,GO:0009116,GO:0009119,GO:0009120,GO:0009164,GO:0009972,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0018130,GO:0019239,GO:0019438,GO:0019439,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0042454,GO:0043094,GO:0043167,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046087,GO:0046092,GO:0046121,GO:0046125,GO:0046127,GO:0046131,GO:0046133,GO:0046135,GO:0046483,GO:0046700,GO:0046872,GO:0046914,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0072529,GO:1901135,GO:1901136,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901657,GO:1901658 3.5.4.5 ko:K01489 ko00240,ko00983,ko01100,map00240,map00983,map01100 - R01878,R02485,R08221 RC00074,RC00514 ko00000,ko00001,ko01000 - - - dCMP_cyt_deam_1 k59_968108_1 485913.Krac_5706 3.28e-26 107.0 COG0596@1|root,COG0596@2|Bacteria,2G8UW@200795|Chloroflexi 200795|Chloroflexi S PFAM alpha beta hydrolase fold - - - - - - - - - - - - Abhydrolase_6 k59_968112_1 317025.Tcr_0416 7.52e-39 140.0 COG1477@1|root,COG1477@2|Bacteria,1QTMG@1224|Proteobacteria,1S9F9@1236|Gammaproteobacteria 1236|Gammaproteobacteria H Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein - - 2.7.1.180 ko:K03734 - - - - ko00000,ko01000 - - - ApbE k59_65057_1 646529.Desaci_4567 7.88e-21 97.1 COG0863@1|root,COG0863@2|Bacteria 2|Bacteria L N-4 methylation of cytosine - - 2.1.1.113 ko:K00590 - - - - ko00000,ko01000,ko02048 - - - N6_N4_Mtase k59_742523_1 1522072.IL54_3790 5.51e-26 103.0 COG0664@1|root,COG0664@2|Bacteria,1RC68@1224|Proteobacteria,2U5S4@28211|Alphaproteobacteria,2K4AN@204457|Sphingomonadales 204457|Sphingomonadales K Crp-like helix-turn-helix domain - - - - - - - - - - - - HTH_Crp_2,cNMP_binding k59_742523_2 1112214.AHIS01000091_gene959 2.65e-71 230.0 COG1626@1|root,COG1626@2|Bacteria,1MWSM@1224|Proteobacteria,2TUAI@28211|Alphaproteobacteria,2K362@204457|Sphingomonadales 204457|Sphingomonadales G Trehalase treF - 3.2.1.28 ko:K01194 ko00500,ko01100,map00500,map01100 - R00010 RC00049 ko00000,ko00001,ko00537,ko01000 - GH37 - Trehalase k59_1533498_1 1454004.AW11_03628 1.91e-64 212.0 COG1858@1|root,COG1858@2|Bacteria,1QVCJ@1224|Proteobacteria,2VIIC@28216|Betaproteobacteria 28216|Betaproteobacteria P cytochrome C peroxidase - - - - - - - - - - - - - k59_1194345_1 443152.MDG893_12620 5.48e-82 262.0 COG1154@1|root,COG1154@2|Bacteria,1MUSJ@1224|Proteobacteria,1RNQD@1236|Gammaproteobacteria,4651D@72275|Alteromonadaceae 1236|Gammaproteobacteria H Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) dxs GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006725,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008614,GO:0008615,GO:0008654,GO:0008661,GO:0009058,GO:0009108,GO:0009110,GO:0009228,GO:0009240,GO:0009987,GO:0016740,GO:0016744,GO:0017144,GO:0018130,GO:0019288,GO:0019438,GO:0019637,GO:0019682,GO:0019752,GO:0019842,GO:0030976,GO:0032787,GO:0034641,GO:0036094,GO:0042180,GO:0042181,GO:0042364,GO:0042723,GO:0042724,GO:0042816,GO:0042819,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046490,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0071704,GO:0072524,GO:0072525,GO:0072527,GO:0072528,GO:0090407,GO:0097159,GO:1901135,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617,GO:1901661,GO:1901663,GO:1901681 2.2.1.7 ko:K01662 ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130 M00096 R05636 RC00032 ko00000,ko00001,ko00002,ko01000 - - iEcSMS35_1347.EcSMS35_0456,iJN746.PP_0527 DXP_synthase_N,Transket_pyr,Transketolase_C k59_1364049_3 469383.Cwoe_4622 3.2e-05 50.8 COG0711@1|root,COG0711@2|Bacteria,2HR5V@201174|Actinobacteria,4CT1D@84995|Rubrobacteria 84995|Rubrobacteria C ATP synthase B/B' CF(0) - - - ko:K02109 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt_B k59_1364049_4 999141.GME_10361 1.15e-17 83.6 COG0712@1|root,COG0712@2|Bacteria,1MVRH@1224|Proteobacteria,1S8X2@1236|Gammaproteobacteria,1XK2G@135619|Oceanospirillales 135619|Oceanospirillales C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation atpH - - ko:K02113 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - OSCP k59_8390_1 331678.Cphamn1_1585 1.39e-95 283.0 COG2993@1|root,COG2993@2|Bacteria 2|Bacteria C Cytochrome C oxidase, mono-heme subunit/FixO ccoO - 1.9.3.1 ko:K00405,ko:K15862 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00156 - - ko00000,ko00001,ko00002,ko01000 3.D.4.3 - iIT341.HP0145 COX1,FixO k59_573630_1 396588.Tgr7_2765 3.2e-30 112.0 COG3079@1|root,COG3079@2|Bacteria 2|Bacteria S Belongs to the UPF0149 family ygfB GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - ko:K09895 - - - - ko00000 - - - UPF0149 k59_573630_2 472759.Nhal_3716 6.14e-51 173.0 COG0006@1|root,COG0006@2|Bacteria,1MUZS@1224|Proteobacteria,1RN0W@1236|Gammaproteobacteria,1WWJH@135613|Chromatiales 135613|Chromatiales E peptidase M24B, X-Pro dipeptidase aminopeptidase - - 3.4.11.9 ko:K01262 - - - - ko00000,ko01000,ko01002 - - - AMP_N,Peptidase_M24 k59_1760161_1 1229909.NSED_03235 1.09e-72 223.0 arCOG01781@1|root,arCOG01781@2157|Archaea,41T0U@651137|Thaumarchaeota 651137|Thaumarchaeota Q Protein of unknown function (DUF1698) - - - - - - - - - - - - Methyltransf_11 k59_1760161_2 1229909.NSED_03230 6.89e-41 147.0 arCOG08742@1|root,arCOG08742@2157|Archaea,41SS8@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1026549_1 1150399.AQYK01000002_gene2600 3.59e-55 187.0 COG3214@1|root,COG3214@2|Bacteria,2GJM7@201174|Actinobacteria,4FKAJ@85023|Microbacteriaceae 201174|Actinobacteria S Winged helix DNA-binding domain - - - ko:K09927 - - - - ko00000 - - - HTH_42 k59_1534472_2 1121937.AUHJ01000006_gene2459 9.32e-54 179.0 COG2141@1|root,COG2141@2|Bacteria,1MWI8@1224|Proteobacteria,1S10Y@1236|Gammaproteobacteria,468VQ@72275|Alteromonadaceae 1236|Gammaproteobacteria C Luciferase-like monooxygenase - - - - - - - - - - - - Bac_luciferase k59_1308456_1 207559.Dde_0590 7.3e-67 219.0 COG1502@1|root,COG1502@2|Bacteria,1MWUW@1224|Proteobacteria,42PV9@68525|delta/epsilon subdivisions,2WJ1M@28221|Deltaproteobacteria,2MG4I@213115|Desulfovibrionales 28221|Deltaproteobacteria I Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol cls-2 - - ko:K06131 ko00564,ko01100,map00564,map01100 - R07390 RC00017 ko00000,ko00001,ko01000 - - - PLDc_2,PLDc_N k59_1195204_1 1463936.JOJI01000070_gene6520 2.72e-68 223.0 COG0154@1|root,COG0154@2|Bacteria,2GKPZ@201174|Actinobacteria 201174|Actinobacteria J Belongs to the amidase family - - 3.5.1.4 ko:K01426 ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120 - R02540,R03096,R03180,R03909,R05551,R05590 RC00010,RC00100,RC00950,RC01025 ko00000,ko00001,ko01000 - - - Amidase k59_805030_1 347834.RHE_CH03638 9.58e-108 320.0 COG1054@1|root,COG1054@2|Bacteria,1MUFV@1224|Proteobacteria,2TUB5@28211|Alphaproteobacteria,4B8DH@82115|Rhizobiaceae 28211|Alphaproteobacteria S Belongs to the UPF0176 family yceA - - ko:K07146 - - - - ko00000 - - - Rhodanese k59_805030_2 1397666.RS24_01593 3.34e-11 60.5 COG2193@1|root,COG2193@2|Bacteria,1RCW7@1224|Proteobacteria,2U70I@28211|Alphaproteobacteria,4BS4M@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria P Iron-storage protein, whose ferroxidase center binds Fe(2 ) ions, oxidizes them by dioxygen to Fe(3 ), and participates in the subsequent Fe(3 ) oxide mineral core formation within the central cavity of the protein complex bfr - 1.16.3.1 ko:K03594 ko00860,map00860 - R00078 RC02758 ko00000,ko00001,ko01000 - - - Ferritin k59_465444_1 1541065.JRFE01000028_gene3443 5.17e-51 190.0 COG2199@1|root,COG2203@1|root,COG5002@1|root,COG2203@2|Bacteria,COG3706@2|Bacteria,COG5002@2|Bacteria,1GPXH@1117|Cyanobacteria 1117|Cyanobacteria T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - GAF,HATPase_c,HisKA,PAS,PHY,Response_reg k59_1652325_1 316407.1799656 3.14e-12 62.8 COG0838@1|root,COG0838@2|Bacteria,1RGUT@1224|Proteobacteria,1S644@1236|Gammaproteobacteria,3XPK3@561|Escherichia 1236|Gammaproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoA GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008137,GO:0008150,GO:0008152,GO:0016020,GO:0016021,GO:0016491,GO:0016651,GO:0016655,GO:0030964,GO:0031224,GO:0031226,GO:0032991,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0050136,GO:0055114,GO:0070469,GO:0070470,GO:0071944,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1990204 1.6.5.3 ko:K00330 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - e_coli_core.b2288,iAF1260.b2288,iAPECO1_1312.APECO1_4277,iB21_1397.B21_02173,iBWG_1329.BWG_2062,iE2348C_1286.E2348C_2428,iEC042_1314.EC042_2529,iEC55989_1330.EC55989_2532,iECABU_c1320.ECABU_c26200,iECBD_1354.ECBD_1373,iECB_1328.ECB_02213,iECDH10B_1368.ECDH10B_2450,iECDH1ME8569_1439.ECDH1ME8569_2225,iECD_1391.ECD_02213,iECED1_1282.ECED1_2752,iECH74115_1262.ECH74115_3427,iECIAI1_1343.ECIAI1_2362,iECIAI39_1322.ECIAI39_2435,iECO103_1326.ECO103_2752,iECO26_1355.ECO26_3276,iECOK1_1307.ECOK1_2521,iECP_1309.ECP_2327,iECS88_1305.ECS88_2435,iECSE_1348.ECSE_2545,iECSP_1301.ECSP_3162,iECUMN_1333.ECUMN_2627,iECW_1372.ECW_m2476,iECs_1301.ECs3172,iEKO11_1354.EKO11_1479,iETEC_1333.ETEC_2423,iEcDH1_1363.EcDH1_1369,iEcE24377_1341.EcE24377A_2581,iEcHS_1320.EcHS_A2437,iEcSMS35_1347.EcSMS35_2442,iEcolC_1368.EcolC_1364,iG2583_1286.G2583_2825,iJN746.PP_4119,iJO1366.b2288,iJR904.b2288,iLF82_1304.LF82_1539,iNRG857_1313.NRG857_11585,iSBO_1134.SBO_2321,iSDY_1059.SDY_2484,iSFV_1184.SFV_2355,iSF_1195.SF2364,iSFxv_1172.SFxv_2608,iSSON_1240.SSON_2345,iS_1188.S2499,iSbBS512_1146.SbBS512_E2664,iUMN146_1321.UM146_05375,iUTI89_1310.UTI89_C2568,iWFL_1372.ECW_m2476,iY75_1357.Y75_RS11995,ic_1306.c2829 Oxidored_q4 k59_1652325_2 316407.85675345 3.12e-134 381.0 COG0377@1|root,COG0377@2|Bacteria,1MUI2@1224|Proteobacteria,1RP4R@1236|Gammaproteobacteria,3XMPW@561|Escherichia 1236|Gammaproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoB GO:0003674,GO:0003824,GO:0003954,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006810,GO:0006811,GO:0006812,GO:0008137,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015672,GO:0015980,GO:0015988,GO:0015990,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0030964,GO:0032991,GO:0034220,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0045333,GO:0048037,GO:0050136,GO:0051179,GO:0051234,GO:0051536,GO:0051539,GO:0051540,GO:0055085,GO:0055114,GO:0070469,GO:0070470,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1902600,GO:1990204 1.6.5.3 ko:K00331 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - iYL1228.KPN_02677 Oxidored_q6 k59_353194_19 398527.Bphyt_4987 6.55e-27 123.0 COG0553@1|root,COG4715@1|root,COG0553@2|Bacteria,COG4715@2|Bacteria,1MV6M@1224|Proteobacteria,2VIEC@28216|Betaproteobacteria,1K27X@119060|Burkholderiaceae 28216|Betaproteobacteria L helicase - - - - - - - - - - - - Helicase_C,SNF2_N,SWIM k59_353194_26 1499967.BAYZ01000197_gene3023 2.14e-84 258.0 COG1192@1|root,COG1192@2|Bacteria 2|Bacteria D plasmid maintenance yqeC - - ko:K03496 - - - - ko00000,ko03036,ko04812 - - - AAA_31 k59_239270_2 999541.bgla_1g04640 3.56e-83 256.0 COG0012@1|root,COG0012@2|Bacteria,1MVM4@1224|Proteobacteria,2VJ1W@28216|Betaproteobacteria,1K3VB@119060|Burkholderiaceae 28216|Betaproteobacteria J ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner ychF - - ko:K06942 - - - - ko00000,ko03009 - - - MMR_HSR1,YchF-GTPase_C k59_1143252_1 1235797.C816_01304 4.47e-11 68.2 COG1344@1|root,COG1344@2|Bacteria,1TP1K@1239|Firmicutes,247JQ@186801|Clostridia,2N6DT@216572|Oscillospiraceae 186801|Clostridia N Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella hag - - ko:K02406 ko02020,ko02040,ko04621,ko04626,ko05132,ko05134,map02020,map02040,map04621,map04626,map05132,map05134 - - - ko00000,ko00001,ko02035 - - - Flagellin_C,Flagellin_N k59_409060_1 1229909.NSED_00940 2.16e-79 242.0 COG0788@1|root,arCOG02826@2157|Archaea,41S78@651137|Thaumarchaeota 651137|Thaumarchaeota F Formyl transferase - - 3.5.1.10 ko:K01433 ko00630,ko00670,map00630,map00670 - R00944 RC00026,RC00111 ko00000,ko00001,ko01000 - - - ACT_6,Formyl_trans_N k59_409060_2 1229909.NSED_00935 3.48e-120 349.0 COG1402@1|root,arCOG04536@2157|Archaea,41SNC@651137|Thaumarchaeota 651137|Thaumarchaeota H Creatinine amidohydrolase - - 3.5.2.10 ko:K01470 ko00330,map00330 - R01884 RC00615 ko00000,ko00001,ko01000 - - - Creatininase k59_1764913_1 555793.WSK_2671 2.49e-132 400.0 COG0542@1|root,COG0542@2|Bacteria,1MURH@1224|Proteobacteria,2TRKI@28211|Alphaproteobacteria,2K00X@204457|Sphingomonadales 204457|Sphingomonadales O Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE clpB - - ko:K03695 ko04213,map04213 - - - ko00000,ko00001,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N k59_296747_1 1459636.NTE_03245 4.39e-90 277.0 arCOG14727@1|root,arCOG14727@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_1143276_1 555793.WSK_0812 7.48e-138 404.0 COG0277@1|root,COG0277@2|Bacteria,1N22A@1224|Proteobacteria 1224|Proteobacteria C FAD linked - - 1.1.3.15 ko:K00104 ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130 - R00475 RC00042 ko00000,ko00001,ko01000 - - - FAD_binding_4 k59_747732_1 1415778.JQMM01000001_gene897 7.8e-08 60.1 COG4223@1|root,COG4223@2|Bacteria,1N10X@1224|Proteobacteria,1RYCQ@1236|Gammaproteobacteria,1J4ZA@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T Protein of unknown function (DUF1631) - - - - - - - - - - - - DUF1631 k59_296755_1 748247.AZKH_2715 1.28e-64 214.0 COG0364@1|root,COG0364@2|Bacteria,1MUN0@1224|Proteobacteria,2VHS1@28216|Betaproteobacteria,2KVPT@206389|Rhodocyclales 206389|Rhodocyclales G Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone - - 1.1.1.363,1.1.1.49 ko:K00036 ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230 M00004,M00006,M00008 R00835,R02736,R10907 RC00001,RC00066 ko00000,ko00001,ko00002,ko01000,ko04147 - - - G6PD_C,G6PD_N k59_70942_1 391037.Sare_3819 1.5e-80 260.0 COG1960@1|root,COG1960@2|Bacteria,2GKK9@201174|Actinobacteria,4DB5R@85008|Micromonosporales 201174|Actinobacteria I Acyl-CoA dehydrogenase, middle domain fadE10 GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944 - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N,DUF1974 k59_1764924_2 1144310.PMI07_005994 1.7e-29 114.0 COG2084@1|root,COG2084@2|Bacteria,1MV48@1224|Proteobacteria,2U0FZ@28211|Alphaproteobacteria,4BBM4@82115|Rhizobiaceae 28211|Alphaproteobacteria I NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase - - 1.1.1.31 ko:K00020 ko00280,ko01100,map00280,map01100 - R05066 RC00099 ko00000,ko00001,ko01000 - - - NAD_binding_11,NAD_binding_2 k59_1425747_1 685035.ADAE01000018_gene498 1.43e-115 353.0 COG1629@1|root,COG4771@2|Bacteria,1MWKN@1224|Proteobacteria,2U10R@28211|Alphaproteobacteria,2K0G1@204457|Sphingomonadales 204457|Sphingomonadales P receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_1143278_1 627192.SLG_36780 4.11e-132 409.0 COG0145@1|root,COG0146@1|root,COG0145@2|Bacteria,COG0146@2|Bacteria,1MU2Y@1224|Proteobacteria,2TQZ6@28211|Alphaproteobacteria,2K2G6@204457|Sphingomonadales 204457|Sphingomonadales EQ COG0145 N-methylhydantoinase A acetone carboxylase, beta subunit - - 3.5.2.9 ko:K01469 ko00480,map00480 - R00251 RC00553 ko00000,ko00001,ko01000 - - - Hydant_A_N,Hydantoinase_A,Hydantoinase_B k59_1143278_2 158500.BV97_03547 2.35e-93 288.0 COG4799@1|root,COG4799@2|Bacteria,1MVAX@1224|Proteobacteria,2TRA0@28211|Alphaproteobacteria,2K0B0@204457|Sphingomonadales 204457|Sphingomonadales I acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) - - 6.4.1.4 ko:K01969 ko00280,ko01100,map00280,map01100 M00036 R04138 RC00367,RC00942 ko00000,ko00001,ko00002,ko01000 - - - Carboxyl_trans k59_862089_1 378806.STAUR_7722 6.09e-105 324.0 COG3344@1|root,COG3344@2|Bacteria,1MVI1@1224|Proteobacteria,42Y93@68525|delta/epsilon subdivisions,2WU1Y@28221|Deltaproteobacteria,2YWK2@29|Myxococcales 28221|Deltaproteobacteria L Reverse transcriptase (RNA-dependent DNA polymerase) - - - - - - - - - - - - RVT_1 k59_1313604_1 266265.Bxe_C0822 3.74e-50 168.0 COG4974@1|root,COG4974@2|Bacteria,1MVAN@1224|Proteobacteria,2VNSH@28216|Betaproteobacteria,1KGQD@119060|Burkholderiaceae 28216|Betaproteobacteria L Phage integrase, N-terminal SAM-like domain - - - ko:K04763 - - - - ko00000,ko03036 - - - Phage_int_SAM_4,Phage_integrase k59_521581_2 1266925.JHVX01000002_gene1081 1.11e-09 59.3 COG3073@1|root,COG3073@2|Bacteria,1QANZ@1224|Proteobacteria,2VVPR@28216|Betaproteobacteria,373CP@32003|Nitrosomonadales 28216|Betaproteobacteria T Anti sigma-E protein RseA, N-terminal domain rseA - - ko:K03597 - - - - ko00000,ko03021 - - - RseA_N k59_635037_2 1122236.KB905143_gene7 1.2e-41 144.0 COG0327@1|root,COG0327@2|Bacteria,1MVUN@1224|Proteobacteria,2VIX1@28216|Betaproteobacteria,2KKRS@206350|Nitrosomonadales 206350|Nitrosomonadales S NIF3 (NGG1p interacting factor 3) - - - - - - - - - - - - NIF3 k59_805081_1 1041142.ATTP01000013_gene625 5.28e-05 45.4 COG2847@1|root,COG4549@1|root,COG2847@2|Bacteria,COG4549@2|Bacteria,1MZ3M@1224|Proteobacteria,2UBUR@28211|Alphaproteobacteria,4B8MI@82115|Rhizobiaceae 28211|Alphaproteobacteria S protein conserved in bacteria - - - ko:K09796 - - - - ko00000,ko03110 - - - DUF1775,PCuAC k59_805081_2 1122137.AQXF01000001_gene2890 3.75e-186 523.0 COG0276@1|root,COG0276@2|Bacteria,1MVR1@1224|Proteobacteria,2TSMS@28211|Alphaproteobacteria 28211|Alphaproteobacteria H Catalyzes the ferrous insertion into protoporphyrin IX hemH GO:0003674,GO:0003824,GO:0004325,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.99.1.1,4.99.1.9 ko:K01772 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R00310,R11329 RC01012 ko00000,ko00001,ko00002,ko01000 - - - Ferrochelatase k59_1143300_1 1042375.AFPL01000054_gene2155 3.27e-53 180.0 COG1377@1|root,COG1377@2|Bacteria,1MUWI@1224|Proteobacteria,1RMHA@1236|Gammaproteobacteria,464JE@72275|Alteromonadaceae 1236|Gammaproteobacteria N Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin flhB - - ko:K02401 ko02040,map02040 - - - ko00000,ko00001,ko02035,ko02044 3.A.6.2 - - Bac_export_2 k59_1595421_1 555793.WSK_0388 9.18e-92 275.0 COG2084@1|root,COG2084@2|Bacteria,1MUGU@1224|Proteobacteria,2TT50@28211|Alphaproteobacteria,2K0B1@204457|Sphingomonadales 204457|Sphingomonadales I COG2084 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases - - 1.1.1.31 ko:K00020 ko00280,ko01100,map00280,map01100 - R05066 RC00099 ko00000,ko00001,ko01000 - - - NAD_binding_11,NAD_binding_2 k59_1595421_2 555793.WSK_0387 7.21e-10 60.1 COG1574@1|root,COG1574@2|Bacteria,1MWP2@1224|Proteobacteria,2TTRU@28211|Alphaproteobacteria,2K1UV@204457|Sphingomonadales 204457|Sphingomonadales S Metal-dependent hydrolase - - - - - - - - - - - - Amidohydro_3 k59_1595423_1 1114964.L485_24025 7.21e-30 114.0 COG2267@1|root,COG2267@2|Bacteria,1MUFB@1224|Proteobacteria,2U36E@28211|Alphaproteobacteria,2K1FJ@204457|Sphingomonadales 204457|Sphingomonadales I Serine aminopeptidase, S33 - - - - - - - - - - - - Abhydrolase_1,Abhydrolase_6,Hydrolase_4 k59_1595423_2 702113.PP1Y_Mpl7082 1.56e-06 48.9 COG2406@1|root,COG2406@2|Bacteria,1QWVU@1224|Proteobacteria 1224|Proteobacteria S Ferritin-like domain - - 1.16.3.1 ko:K03594 ko00860,map00860 - R00078 RC02758 ko00000,ko00001,ko01000 - - - Ferritin k59_409100_1 1042377.AFPJ01000025_gene612 1.08e-57 189.0 COG2755@1|root,COG2755@2|Bacteria,1RCXZ@1224|Proteobacteria,1S3QU@1236|Gammaproteobacteria,466ZZ@72275|Alteromonadaceae 1236|Gammaproteobacteria E COG2755 Lysophospholipase L1 and related esterases tesA GO:0003674,GO:0003824,GO:0004620,GO:0004622,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0016289,GO:0016290,GO:0016298,GO:0016787,GO:0016788,GO:0016790,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0042802,GO:0043170,GO:0044238,GO:0044464,GO:0047617,GO:0052689,GO:0071704,GO:0140096,GO:1901564 3.1.1.5 ko:K10804 ko01040,map01040 - - - ko00000,ko00001,ko01000,ko01004 - - iECED1_1282.ECED1_0521,iLF82_1304.LF82_2242,iNRG857_1313.NRG857_02365 Lipase_GDSL_2 k59_1143309_1 869210.Marky_0959 2.69e-13 69.3 COG0119@1|root,COG0119@2|Bacteria,1WI4S@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus E Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) leuA - 2.3.3.13 ko:K01649 ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230 M00432 R01213 RC00004,RC00470,RC02754 br01601,ko00000,ko00001,ko00002,ko01000 - - - HMGL-like,LeuA_dimer k59_1143309_2 290397.Adeh_1976 3.06e-93 283.0 COG0059@1|root,COG0059@2|Bacteria,1MV7M@1224|Proteobacteria,42MRS@68525|delta/epsilon subdivisions,2WJW8@28221|Deltaproteobacteria,2YU99@29|Myxococcales 28221|Deltaproteobacteria H Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate ilvC - 1.1.1.86 ko:K00053 ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R03051,R04439,R04440,R05068,R05069,R05071 RC00726,RC00836,RC00837,RC01726 ko00000,ko00001,ko00002,ko01000 - - - IlvC,IlvN k59_1031350_2 1411685.U062_01222 1.04e-97 330.0 COG1033@1|root,COG1033@2|Bacteria,1MUE1@1224|Proteobacteria,1RN01@1236|Gammaproteobacteria,1J5BG@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S MMPL family - - - ko:K07003 - - - - ko00000 - - - MMPL k59_635686_1 420324.KI912031_gene2900 6.06e-65 207.0 COG0561@1|root,COG0561@2|Bacteria,1R4WX@1224|Proteobacteria,2TSDR@28211|Alphaproteobacteria 28211|Alphaproteobacteria S hydrolases of the HAD superfamily - - - - - - - - - - - - Hydrolase_3 k59_862832_1 316407.85675587 6.57e-119 349.0 COG0644@1|root,COG0644@2|Bacteria,1MVU6@1224|Proteobacteria,1RNY5@1236|Gammaproteobacteria,3XMS4@561|Escherichia 1236|Gammaproteobacteria C electron transfer flavoprotein-quinone oxidoreductase YgcN ygcN GO:0006575,GO:0006577,GO:0006807,GO:0008150,GO:0008152,GO:0009437,GO:0009987,GO:0034641,GO:0044237,GO:0071704,GO:0097164,GO:1901564 - ko:K00313 - - - - ko00000,ko01000 - - - DAO,FAD_binding_2,FAD_binding_3 k59_1032026_1 1131266.ARWQ01000002_gene513 5.72e-63 205.0 COG2025@1|root,arCOG00448@2157|Archaea,41SZJ@651137|Thaumarchaeota 651137|Thaumarchaeota C Electron transfer flavoprotein domain - - - ko:K03522 - - - - ko00000,ko04147 - - - ETF,ETF_alpha k59_1032026_2 1131266.ARWQ01000002_gene512 2.66e-54 186.0 COG0644@1|root,COG2440@1|root,arCOG00570@2157|Archaea,arCOG01984@2157|Archaea,41SXJ@651137|Thaumarchaeota 651137|Thaumarchaeota C Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains - - - ko:K00313 - - - - ko00000,ko01000 - - - - k59_692206_1 1415778.JQMM01000001_gene1018 1.36e-94 285.0 COG0130@1|root,COG0130@2|Bacteria,1MV0N@1224|Proteobacteria,1RMKP@1236|Gammaproteobacteria,1J4X5@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs truB GO:0000049,GO:0001522,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016556,GO:0016853,GO:0016866,GO:0031119,GO:0034337,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990481 5.4.99.25 ko:K03177 - - - - ko00000,ko01000,ko03016 - - - TruB-C_2,TruB_C_2,TruB_N k59_1708985_1 316407.85676228 7.55e-106 307.0 COG1280@1|root,COG1280@2|Bacteria,1MX0K@1224|Proteobacteria,1RP43@1236|Gammaproteobacteria,3XP86@561|Escherichia 1236|Gammaproteobacteria E Threonine efflux protein rhtC GO:0003333,GO:0003674,GO:0005215,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006820,GO:0006865,GO:0008150,GO:0008509,GO:0008514,GO:0015075,GO:0015171,GO:0015175,GO:0015179,GO:0015318,GO:0015711,GO:0015804,GO:0015807,GO:0015849,GO:0016020,GO:0022857,GO:0034220,GO:0042968,GO:0042970,GO:0044464,GO:0046942,GO:0046943,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0098656,GO:1902475,GO:1903825,GO:1905039 - ko:K05835 - - - - ko00000,ko02000 2.A.76.1.2 - - LysE k59_1540089_1 1117647.M5M_08390 7.76e-08 59.3 COG0810@1|root,COG0810@2|Bacteria,1PEER@1224|Proteobacteria,1RPPU@1236|Gammaproteobacteria,1J7A9@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M COG0810 Periplasmic protein TonB, links inner and outer membranes - - - ko:K03832 - - - - ko00000,ko02000 2.C.1.1 - - Chalcone_3,TonB_2,TonB_C k59_635714_2 925775.XVE_2956 3.34e-11 62.4 2EK02@1|root,33DQM@2|Bacteria,1NKQA@1224|Proteobacteria,1SJBA@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_1765623_1 566466.NOR53_3099 1.59e-158 450.0 COG2805@1|root,COG2805@2|Bacteria,1MU3J@1224|Proteobacteria,1RN8G@1236|Gammaproteobacteria,1J4KJ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria NU Tfp pilus assembly protein, pilus retraction ATPase PilT pilT GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - ko:K02669 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE k59_409795_1 452637.Oter_2989 2.36e-95 308.0 COG1197@1|root,COG1197@2|Bacteria,46S6Y@74201|Verrucomicrobia,3K7Q7@414999|Opitutae 414999|Opitutae L Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site mfd - - ko:K03723 ko03420,map03420 - - - ko00000,ko00001,ko01000,ko03400 - - - CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF k59_1370771_2 292415.Tbd_2397 7.95e-53 185.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2VI3F@28216|Betaproteobacteria,1KSFJ@119069|Hydrogenophilales 119069|Hydrogenophilales V AcrB/AcrD/AcrF family - - - - - - - - - - - - ACR_tran k59_1765628_1 290397.Adeh_0602 1.42e-39 140.0 COG0835@1|root,COG0835@2|Bacteria,1RAH1@1224|Proteobacteria,42S69@68525|delta/epsilon subdivisions,2X5EQ@28221|Deltaproteobacteria,2Z35B@29|Myxococcales 28221|Deltaproteobacteria NT Two component signalling adaptor domain - - - ko:K03408 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - CheW k59_973888_1 314287.GB2207_11038 1.48e-33 119.0 COG2921@1|root,COG2921@2|Bacteria,1RGV5@1224|Proteobacteria,1S61Y@1236|Gammaproteobacteria,1J700@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Belongs to the UPF0250 family ybeD GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - ko:K09158 - - - - ko00000 - - - DUF493 k59_973888_2 1415778.JQMM01000001_gene1027 5.06e-50 164.0 COG0321@1|root,COG0321@2|Bacteria,1MU6A@1224|Proteobacteria,1RMXQ@1236|Gammaproteobacteria,1J5SC@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate lipB GO:0003674,GO:0003824,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009106,GO:0009107,GO:0009108,GO:0009249,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010605,GO:0010629,GO:0016053,GO:0016415,GO:0016740,GO:0016746,GO:0016747,GO:0016772,GO:0016779,GO:0016874,GO:0016879,GO:0016979,GO:0018065,GO:0018130,GO:0018193,GO:0018205,GO:0019222,GO:0019538,GO:0019752,GO:0032787,GO:0033819,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0048519,GO:0050789,GO:0051186,GO:0051188,GO:0051604,GO:0060255,GO:0065007,GO:0071704,GO:0072330,GO:0140096,GO:1901360,GO:1901362,GO:1901564,GO:1901576 2.3.1.181 ko:K03801 ko00785,ko01100,map00785,map01100 - R07766,R07769 RC00039,RC00992,RC02867 ko00000,ko00001,ko01000 - - iECSF_1327.ECSF_0569,iSFV_1184.SFV_0696,iSFxv_1172.SFxv_0718 BPL_LplA_LipB k59_1653058_1 227086.JGI_V11_33711 4.69e-68 215.0 2BBKE@1|root,2S0Y6@2759|Eukaryota 2759|Eukaryota - - - - - - - - - - - - - - - k59_297489_1 1155718.KB891854_gene3145 1.23e-05 48.9 COG0183@1|root,COG0183@2|Bacteria,2GJAC@201174|Actinobacteria 201174|Actinobacteria I Belongs to the thiolase family - - 2.3.1.16,2.3.1.9 ko:K00626,ko:K00632 ko00071,ko00072,ko00280,ko00281,ko00310,ko00362,ko00380,ko00592,ko00620,ko00630,ko00640,ko00642,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00281,map00310,map00362,map00380,map00592,map00620,map00630,map00640,map00642,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00087,M00088,M00095,M00113,M00373,M00374,M00375 R00238,R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095 RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N k59_918220_1 1286093.C266_20180 5.92e-68 215.0 COG0356@1|root,COG0356@2|Bacteria,1MV87@1224|Proteobacteria,2VHR5@28216|Betaproteobacteria,1K3JW@119060|Burkholderiaceae 28216|Betaproteobacteria C it plays a direct role in the translocation of protons across the membrane atpB - - ko:K02108 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko03110 3.A.2.1 - - ATP-synt_A k59_642612_2 1384056.N787_02335 1.1e-11 62.4 COG2938@1|root,COG2938@2|Bacteria,1N7P4@1224|Proteobacteria,1SCKB@1236|Gammaproteobacteria,1X883@135614|Xanthomonadales 135614|Xanthomonadales S Flavinator of succinate dehydrogenase - - - ko:K09159 - - - - ko00000,ko02048 - - - Sdh5 k59_247507_2 1386969.AWTB01000102_gene3715 4.49e-34 134.0 COG0474@1|root,COG0474@2|Bacteria,2GJJC@201174|Actinobacteria,4GD54@85026|Gordoniaceae 201174|Actinobacteria P E1-E2 ATPase ctpE GO:0003674,GO:0003824,GO:0005215,GO:0005388,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006816,GO:0008150,GO:0008324,GO:0015075,GO:0015085,GO:0015318,GO:0015399,GO:0015405,GO:0015662,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030001,GO:0031224,GO:0031226,GO:0034220,GO:0042623,GO:0042625,GO:0042626,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043492,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0070588,GO:0070838,GO:0071944,GO:0072511,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0099131,GO:0099132 - ko:K12952 - - - - ko00000,ko01000 3.A.3.23 - - E1-E2_ATPase,Hydrolase k59_980712_1 392499.Swit_0914 5.44e-11 68.2 COG1629@1|root,COG4771@2|Bacteria,1MVFB@1224|Proteobacteria,2U0N7@28211|Alphaproteobacteria,2KEFU@204457|Sphingomonadales 204457|Sphingomonadales P TonB-dependent receptor plug - - - - - - - - - - - - Plug,TonB_dep_Rec k59_1039995_1 1249975.JQLP01000005_gene2732 1.46e-74 225.0 2ECVM@1|root,336SY@2|Bacteria,4P7DC@976|Bacteroidetes 976|Bacteroidetes - - - - - - - - - - - - - - - k59_1039995_2 1249975.JQLP01000005_gene2731 4.66e-48 157.0 28W1J@1|root,2ZI2J@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_1151416_1 1144305.PMI02_00141 2.84e-84 260.0 COG5361@1|root,COG5361@2|Bacteria,1R8Y7@1224|Proteobacteria,2UPHX@28211|Alphaproteobacteria,2K48D@204457|Sphingomonadales 204457|Sphingomonadales S Conserved Protein - - - - - - - - - - - - DUF1214 k59_1151416_2 1144305.PMI02_00142 0.00084 40.8 COG1028@1|root,COG1028@2|Bacteria,1RCCT@1224|Proteobacteria,2U5VU@28211|Alphaproteobacteria,2K66H@204457|Sphingomonadales 204457|Sphingomonadales IQ KR domain - - - - - - - - - - - - adh_short_C2 k59_1660334_1 1122599.AUGR01000015_gene2651 9.73e-55 181.0 COG0341@1|root,COG0341@2|Bacteria,1MU74@1224|Proteobacteria,1RNTY@1236|Gammaproteobacteria,1XIA9@135619|Oceanospirillales 135619|Oceanospirillales U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA secF - - ko:K03074 ko03060,ko03070,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 2.A.6.4,3.A.5.2,3.A.5.7 - - SecD_SecF,Sec_GG k59_1433293_2 29850.GGTG_02550T0 0.000536 50.4 COG0666@1|root,KOG0504@2759|Eukaryota,3AFQA@33154|Opisthokonta,3PAQV@4751|Fungi,3QNMA@4890|Ascomycota,217AZ@147550|Sordariomycetes 4751|Fungi S ankyrin repeat protein - - - - - - - - - - - - Ank,Ank_2,Ank_3,Ank_4 k59_1320964_1 1131553.JIBI01000002_gene1756 1.9e-49 178.0 COG0025@1|root,COG0025@2|Bacteria,1QTUE@1224|Proteobacteria,2WHHS@28216|Betaproteobacteria,373VS@32003|Nitrosomonadales 28216|Betaproteobacteria P Sodium/hydrogen exchanger family - - - - - - - - - - - - Na_H_Exchanger,TrkA_N k59_755468_1 292459.STH2616 1.89e-57 201.0 COG2217@1|root,COG2217@2|Bacteria,1TP5S@1239|Firmicutes,247MW@186801|Clostridia 186801|Clostridia P ATPase, P-type (transporting), HAD superfamily, subfamily IC - - 3.6.3.4,3.6.3.54 ko:K01533,ko:K17686 ko01524,ko04016,map01524,map04016 - R00086 RC00002 ko00000,ko00001,ko01000 3.A.3.5 - - E1-E2_ATPase,HMA,Hydrolase k59_642621_1 1537715.JQFJ01000004_gene2588 2.9e-65 208.0 COG0264@1|root,COG0264@2|Bacteria,1MUS2@1224|Proteobacteria,2TQM0@28211|Alphaproteobacteria,2JZY1@204457|Sphingomonadales 204457|Sphingomonadales J Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome tsf - - ko:K02357 - - - - ko00000,ko03012,ko03029 - - - EF_TS k59_1716695_1 1122137.AQXF01000003_gene2475 9.97e-146 422.0 COG1473@1|root,COG1473@2|Bacteria,1MUIV@1224|Proteobacteria,2TR5B@28211|Alphaproteobacteria 28211|Alphaproteobacteria S amidohydrolase - - - - - - - - - - - - M20_dimer,Peptidase_M20 k59_247523_1 1122137.AQXF01000004_gene1791 4.07e-133 389.0 COG0141@1|root,COG0141@2|Bacteria,1MUUF@1224|Proteobacteria,2TSBN@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine hisD GO:0000105,GO:0003674,GO:0003824,GO:0004399,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0052803,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.23 ko:K00013 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R01158,R01163,R03012 RC00099,RC00242,RC00463 ko00000,ko00001,ko00002,ko01000 - - - Histidinol_dh k59_642623_1 338966.Ppro_1841 3.26e-72 226.0 COG2801@1|root,COG2801@2|Bacteria,1PBHA@1224|Proteobacteria 1224|Proteobacteria L Transposase and inactivated derivatives - - 2.7.7.49 ko:K00986,ko:K07497 - - - - ko00000,ko01000 - - - HTH_32,rve,rve_3 k59_79486_1 1453501.JELR01000001_gene3011 6.7e-99 300.0 COG1160@1|root,COG1160@2|Bacteria,1MU9S@1224|Proteobacteria,1RMSF@1236|Gammaproteobacteria,464AT@72275|Alteromonadaceae 1236|Gammaproteobacteria S GTPase that plays an essential role in the late steps of ribosome biogenesis der GO:0000027,GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005515,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006996,GO:0008150,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0022607,GO:0022613,GO:0022618,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0032794,GO:0034622,GO:0035639,GO:0036094,GO:0042254,GO:0042255,GO:0042273,GO:0043021,GO:0043022,GO:0043023,GO:0043167,GO:0043168,GO:0043933,GO:0044085,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:0097159,GO:0097216,GO:0097367,GO:1901265,GO:1901363 - ko:K03977 - - - - ko00000,ko03009 - - - KH_dom-like,MMR_HSR1 k59_191220_1 702113.PP1Y_AT5454 2.93e-60 192.0 COG0805@1|root,COG0805@2|Bacteria,1MVAY@1224|Proteobacteria,2TTIX@28211|Alphaproteobacteria,2K1PD@204457|Sphingomonadales 204457|Sphingomonadales U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides tatC - - ko:K03118 ko03060,ko03070,map03060,map03070 M00336 - - ko00000,ko00001,ko00002,ko02044 2.A.64 - - TatC k59_191220_2 702113.PP1Y_AT5449 4.99e-36 128.0 COG1826@1|root,COG1826@2|Bacteria,1N73F@1224|Proteobacteria,2UF4Z@28211|Alphaproteobacteria,2K60Q@204457|Sphingomonadales 204457|Sphingomonadales U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation tatB - - ko:K03117 ko03060,ko03070,map03060,map03070 M00336 - - ko00000,ko00001,ko00002,ko02044 2.A.64 - - MttA_Hcf106 k59_1320975_2 1229909.NSED_09260 1.01e-94 278.0 COG0652@1|root,arCOG04767@2157|Archaea,41T32@651137|Thaumarchaeota 651137|Thaumarchaeota O peptidyl-prolyl cis-trans isomerase - - 5.2.1.8 ko:K03768 - - - - ko00000,ko01000,ko03110 - - - Pro_isomerase k59_980733_1 1121405.dsmv_2145 2.19e-67 222.0 COG2239@1|root,COG2239@2|Bacteria,1MW24@1224|Proteobacteria,42MA7@68525|delta/epsilon subdivisions,2WIPC@28221|Deltaproteobacteria,2MI8B@213118|Desulfobacterales 28221|Deltaproteobacteria P Acts as a magnesium transporter - - - ko:K06213 - - - - ko00000,ko02000 1.A.26.1 - - CBS,MgtE,MgtE_N k59_980733_2 1283299.AUKG01000002_gene5294 1.34e-21 96.7 COG1381@1|root,COG1381@2|Bacteria,2GK81@201174|Actinobacteria,4CQNS@84995|Rubrobacteria 84995|Rubrobacteria L Involved in DNA repair and RecF pathway recombination recO - - ko:K03584 ko03440,map03440 - - - ko00000,ko00001,ko03400 - - - RecO_C,RecO_N k59_1772250_1 1121374.KB891589_gene127 9.26e-96 295.0 COG0511@1|root,COG5016@1|root,COG0511@2|Bacteria,COG5016@2|Bacteria,1QTTG@1224|Proteobacteria,1RNG6@1236|Gammaproteobacteria 1236|Gammaproteobacteria CI Oxaloacetate oadA - 4.1.1.3 ko:K01571 ko00620,ko01100,map00620,map01100 - R00217 RC00040 ko00000,ko00001,ko01000,ko02000 3.B.1.1.1 - - Biotin_lipoyl,HMGL-like,PYC_OADA k59_1491515_1 44056.XP_009037550.1 1.01e-87 278.0 COG4992@1|root,KOG1401@2759|Eukaryota 2759|Eukaryota E N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity - - - - - - - - - - - - Aminotran_3,PRK k59_755487_1 1121861.KB899914_gene1961 8.06e-59 193.0 COG0448@1|root,COG0448@2|Bacteria,1MVTC@1224|Proteobacteria,2TR6D@28211|Alphaproteobacteria,2JQNH@204441|Rhodospirillales 204441|Rhodospirillales H Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans glgC - 2.7.7.27 ko:K00975 ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026 M00565 R00948 RC00002 ko00000,ko00001,ko00002,ko01000 - - - NTP_transferase k59_755487_2 1122137.AQXF01000007_gene3564 1.43e-33 128.0 COG0297@1|root,COG0297@2|Bacteria,1MUGM@1224|Proteobacteria,2TT73@28211|Alphaproteobacteria 28211|Alphaproteobacteria G Synthesizes alpha-1,4-glucan chains using ADP-glucose glgA - 2.4.1.21 ko:K00703 ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026 M00565 R02421 RC00005 ko00000,ko00001,ko00002,ko01000,ko01003 - GT5 - Glyco_transf_5,Glycos_transf_1 k59_755502_1 1381123.AYOD01000001_gene1111 2.07e-06 52.4 COG0834@1|root,COG0834@2|Bacteria,1MXME@1224|Proteobacteria,2TT4J@28211|Alphaproteobacteria,43HV1@69277|Phyllobacteriaceae 28211|Alphaproteobacteria ET Ligated ion channel L-glutamate- and glycine-binding site fliY - - ko:K02030 - M00236 - - ko00000,ko00002,ko02000 3.A.1.3 - - SBP_bac_3 k59_755502_2 998088.B565_1514 5.88e-37 132.0 COG4215@1|root,COG4215@2|Bacteria,1MY2N@1224|Proteobacteria,1RNYD@1236|Gammaproteobacteria,1Y47J@135624|Aeromonadales 135624|Aeromonadales P ABC transporter - - - ko:K10024 ko02010,map02010 M00235 - - ko00000,ko00001,ko00002,ko02000 3.A.1.3.11 - - BPD_transp_1 k59_1040059_1 1122137.AQXF01000001_gene3384 3.02e-125 371.0 COG0138@1|root,COG0138@2|Bacteria,1MUDQ@1224|Proteobacteria,2TRMY@28211|Alphaproteobacteria 28211|Alphaproteobacteria F bifunctional purine biosynthesis protein PurH purH - 2.1.2.3,3.5.4.10 ko:K00602 ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523 M00048 R01127,R04560 RC00026,RC00263,RC00456 ko00000,ko00001,ko00002,ko01000,ko04147 - - - AICARFT_IMPCHas,MGS k59_1433334_1 1549858.MC45_04555 7.42e-24 102.0 COG1595@1|root,COG1595@2|Bacteria,1RM2Q@1224|Proteobacteria,2UP4Y@28211|Alphaproteobacteria,2K4ZU@204457|Sphingomonadales 204457|Sphingomonadales K Belongs to the sigma-70 factor family. ECF subfamily - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 k59_1040060_1 1453501.JELR01000001_gene3244 1.19e-71 223.0 COG0811@1|root,COG0811@2|Bacteria,1NXZ9@1224|Proteobacteria,1S154@1236|Gammaproteobacteria,465XD@72275|Alteromonadaceae 1236|Gammaproteobacteria U MotA/TolQ/ExbB proton channel family - - - - - - - - - - - - MotA_ExbB k59_586684_1 555793.WSK_1683 4.9e-70 224.0 COG0460@1|root,COG0460@2|Bacteria,1MUDC@1224|Proteobacteria,2TQWS@28211|Alphaproteobacteria,2K2BW@204457|Sphingomonadales 204457|Sphingomonadales E homoserine dehydrogenase thrA - 1.1.1.3 ko:K00003 ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230 M00017,M00018 R01773,R01775 RC00087 ko00000,ko00001,ko00002,ko01000 - - - ACT,Homoserine_dh,NAD_binding_3 k59_22188_1 452637.Oter_0143 3.61e-11 68.9 COG1629@1|root,COG4771@2|Bacteria 2|Bacteria P TonB-dependent receptor - - - - - - - - - - - - CarboxypepD_reg,Plug,TonB_dep_Rec k59_1321714_1 316407.1736850 2.57e-112 322.0 COG4574@1|root,COG4574@2|Bacteria,1MZEN@1224|Proteobacteria,1S6Y9@1236|Gammaproteobacteria,3XP1A@561|Escherichia 1236|Gammaproteobacteria M General inhibitor of pancreatic serine proteases inhibits chymotrypsin, trypsin, elastases, factor X, kallikrein as well as a variety of other proteases eco GO:0003674,GO:0004857,GO:0004866,GO:0004867,GO:0005575,GO:0005623,GO:0008150,GO:0009892,GO:0010466,GO:0010605,GO:0010951,GO:0019222,GO:0030162,GO:0030234,GO:0030288,GO:0030313,GO:0030414,GO:0031323,GO:0031324,GO:0031975,GO:0032268,GO:0032269,GO:0042597,GO:0043086,GO:0044092,GO:0044464,GO:0045861,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0051336,GO:0051346,GO:0052547,GO:0052548,GO:0060255,GO:0061134,GO:0061135,GO:0065007,GO:0065009,GO:0080090,GO:0098772 - ko:K08276 - - - - ko00000 - - - Ecotin k59_1041090_1 1353528.DT23_02060 1.96e-05 52.8 28K40@1|root,2Z9T4@2|Bacteria,1R3V0@1224|Proteobacteria,2U1QP@28211|Alphaproteobacteria,2XNU4@285107|Thioclava 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_80561_1 1417296.U879_08050 1.37e-93 283.0 COG1856@1|root,COG1856@2|Bacteria,1R6PW@1224|Proteobacteria,2U1YU@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Radical SAM - - - ko:K09711 - - - - ko00000 - - - Radical_SAM k59_362855_1 1124983.PFLCHA0_c30270 1.1e-17 83.2 COG1538@1|root,COG1538@2|Bacteria,1MWCJ@1224|Proteobacteria,1RQQV@1236|Gammaproteobacteria,1YPHW@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria MU Type I secretion outer membrane protein tolC - - ko:K12340 ko01501,ko01503,ko02020,ko03070,ko04626,ko05133,map01501,map01503,map02020,map03070,map04626,map05133 M00325,M00326,M00339,M00571,M00575,M00646,M00647,M00696,M00697,M00709,M00720,M00821 - - ko00000,ko00001,ko00002,ko01504,ko02000,ko02044 1.B.17,2.A.6.2 - - OEP k59_362855_2 502347.ESCAB7627_1501 2.53e-22 97.8 COG1560@1|root,COG1560@2|Bacteria,1MVNI@1224|Proteobacteria,1RMZ5@1236|Gammaproteobacteria,3XMPR@561|Escherichia 1236|Gammaproteobacteria M Catalyzes the transfer of palmitoleate from palmitoleoyl-acyl carrier protein (ACP) to Kdo(2)-lipid IV(A) to form Kdo(2)-(palmitoleoyl)-lipid IV(A) lpxL GO:0003674,GO:0003824,GO:0005975,GO:0006082,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0006950,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0008951,GO:0009058,GO:0009247,GO:0009266,GO:0009311,GO:0009312,GO:0009409,GO:0009628,GO:0009987,GO:0016051,GO:0016053,GO:0016740,GO:0016746,GO:0016747,GO:0019637,GO:0019752,GO:0036103,GO:0036104,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0046467,GO:0050896,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 2.3.1.241,2.3.1.242 ko:K02517,ko:K12974 ko00540,ko01100,map00540,map01100 M00060 R05146,R10906 RC00037,RC00039 ko00000,ko00001,ko00002,ko01000,ko01005 - - iEC042_1314.EC042_2597 Lip_A_acyltrans k59_23230_1 472759.Nhal_2214 5.15e-78 247.0 COG0297@1|root,COG0297@2|Bacteria,1MUGM@1224|Proteobacteria,1RNMP@1236|Gammaproteobacteria,1WWCY@135613|Chromatiales 135613|Chromatiales G Synthesizes alpha-1,4-glucan chains using ADP-glucose glgA - 2.4.1.21 ko:K00703 ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026 M00565 R02421 RC00005 ko00000,ko00001,ko00002,ko01000,ko01003 - GT5 - Glyco_transf_5,Glycos_transf_1 k59_925982_1 1499967.BAYZ01000069_gene1846 4.59e-41 146.0 COG0714@1|root,COG0714@2|Bacteria,2NNMQ@2323|unclassified Bacteria 2|Bacteria S ATPase associated with various cellular moxR - - ko:K03924 - - - - ko00000,ko01000 - - - AAA_3 k59_192019_1 1122137.AQXF01000006_gene931 2.23e-100 296.0 COG0321@1|root,COG0321@2|Bacteria,1MU6A@1224|Proteobacteria,2TRXJ@28211|Alphaproteobacteria 28211|Alphaproteobacteria H Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate lipB GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009249,GO:0009987,GO:0010467,GO:0018065,GO:0018193,GO:0018205,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0051604,GO:0071704,GO:1901564 2.3.1.181 ko:K03801 ko00785,ko01100,map00785,map01100 - R07766,R07769 RC00039,RC00992,RC02867 ko00000,ko00001,ko01000 - - - BPL_LplA_LipB k59_643408_1 517417.Cpar_1700 2.58e-122 362.0 COG3004@1|root,COG3004@2|Bacteria,1FDWE@1090|Chlorobi 1090|Chlorobi P ) H( ) antiporter that extrudes sodium in exchange for external protons nhaA - - ko:K03313 - - - - ko00000,ko02000 2.A.33.1 - - Na_H_antiport_1 k59_1095472_2 717785.HYPMC_3093 9.1e-38 143.0 2BF9B@1|root,32SMX@2|Bacteria 2|Bacteria C Cytochrome c554 and c-prime - - - - - - - - - - - - Cytochrome_C554 k59_23243_1 521045.Kole_0003 2.37e-05 49.3 COG0220@1|root,COG0220@2|Bacteria,2GCR3@200918|Thermotogae 200918|Thermotogae J Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA trmB GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008176,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0034708,GO:0036265,GO:0043170,GO:0043412,GO:0043414,GO:0043527,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0106004,GO:0140098,GO:0140101,GO:1901360,GO:1902494,GO:1990234 2.1.1.33 ko:K03439 - - - - ko00000,ko01000,ko03016 - - - Methyltransf_4 k59_23243_2 1144275.COCOR_05601 4.44e-36 144.0 COG0616@1|root,COG0616@2|Bacteria,1MUXE@1224|Proteobacteria,42QUN@68525|delta/epsilon subdivisions,2WN6Q@28221|Deltaproteobacteria,2YU60@29|Myxococcales 28221|Deltaproteobacteria OU signal peptide peptidase SppA, 36K type sppA2 - - ko:K04773 - - - - ko00000,ko01000,ko01002 - - - Peptidase_S49 k59_248544_1 1133850.SHJG_1246 3.38e-65 229.0 COG0439@1|root,COG1984@1|root,COG2049@1|root,COG4770@1|root,COG0439@2|Bacteria,COG1984@2|Bacteria,COG2049@2|Bacteria,COG4770@2|Bacteria,2GIZP@201174|Actinobacteria 201174|Actinobacteria I carboxylase uca - 6.3.4.6 ko:K01941 ko00220,ko00791,ko01100,map00220,map00791,map01100 - R00774 RC00378 ko00000,ko00001,ko01000 - - - Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2,CT_A_B,CT_C_D k59_1717866_1 1123392.AQWL01000002_gene1766 2.95e-77 246.0 COG2010@1|root,COG3391@1|root,COG2010@2|Bacteria,COG3391@2|Bacteria,1PYK3@1224|Proteobacteria,2VIU7@28216|Betaproteobacteria,1KSV4@119069|Hydrogenophilales 119069|Hydrogenophilales C Cytochrome D1 heme domain - - - - - - - - - - - - Cytochrom_D1,Cytochrome_CBB3 k59_529505_1 323261.Noc_0173 2.39e-108 325.0 COG0111@1|root,COG0111@2|Bacteria,1MU5Z@1224|Proteobacteria,1RPEY@1236|Gammaproteobacteria,1WWZH@135613|Chromatiales 135613|Chromatiales EH D-isomer specific 2-hydroxyacid dehydrogenase - - 1.1.1.399,1.1.1.95 ko:K00058 ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230 M00020 R01513 RC00031 ko00000,ko00001,ko00002,ko01000,ko04147 - - - 2-Hacid_dh,2-Hacid_dh_C k59_925993_1 1088721.NSU_1740 2.86e-131 379.0 COG2025@1|root,COG2025@2|Bacteria,1MUFI@1224|Proteobacteria,2TR10@28211|Alphaproteobacteria,2K1AU@204457|Sphingomonadales 204457|Sphingomonadales C Electron transfer flavoprotein etfA - - ko:K03522 - - - - ko00000,ko04147 - - - ETF,ETF_alpha k59_587721_1 1144319.PMI16_03366 1.17e-24 107.0 COG5002@1|root,COG5002@2|Bacteria,1MWF3@1224|Proteobacteria,2VIBV@28216|Betaproteobacteria,473QD@75682|Oxalobacteraceae 28216|Betaproteobacteria T Domain of unknown function (DUF3329) phoR - 2.7.13.3 ko:K07636 ko02020,map02020 M00434 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - DUF3329,HATPase_c,HisKA,PAS,PAS_8 k59_23254_1 159087.Daro_3203 1.32e-50 179.0 COG3808@1|root,COG3808@2|Bacteria,1MUQ3@1224|Proteobacteria,2VI3K@28216|Betaproteobacteria,2KV9E@206389|Rhodocyclales 206389|Rhodocyclales C Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force hppA - 3.6.1.1 ko:K15987 ko00190,map00190 - - - ko00000,ko00001,ko01000 3.A.10.1 - - H_PPase k59_1717890_1 1342302.JASC01000014_gene745 1.9e-77 244.0 COG0577@1|root,COG0577@2|Bacteria,1MVN1@1224|Proteobacteria,2TTEF@28211|Alphaproteobacteria,3ZV5I@60136|Sulfitobacter 28211|Alphaproteobacteria V MacB-like periplasmic core domain - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_1661181_1 517418.Ctha_1209 2.35e-60 209.0 COG0841@1|root,COG0841@2|Bacteria,1FDQI@1090|Chlorobi 1090|Chlorobi V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K03296 - - - - ko00000 2.A.6.2 - - ACR_tran k59_1152526_1 436308.Nmar_0847 2.44e-106 310.0 COG0041@1|root,arCOG02464@2157|Archaea,41SN4@651137|Thaumarchaeota 651137|Thaumarchaeota F Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) purE - 5.4.99.18 ko:K01588 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R07405 RC01947 ko00000,ko00001,ko00002,ko01000 - - - AIRC k59_473803_1 1229909.NSED_07590 5.79e-98 286.0 COG0503@1|root,arCOG00030@2157|Archaea,41SMR@651137|Thaumarchaeota 651137|Thaumarchaeota F Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis apt - 2.4.2.7 ko:K00759 ko00230,ko01100,map00230,map01100 - R00190,R01229,R04378 RC00063 ko00000,ko00001,ko01000,ko04147 - - - Pribosyltran k59_1379463_1 926550.CLDAP_22200 1.81e-17 83.6 COG0111@1|root,COG0111@2|Bacteria,2G67B@200795|Chloroflexi 200795|Chloroflexi C D-isomer specific 2-hydroxyacid dehydrogenase serA - 1.1.1.310,1.1.1.399,1.1.1.95 ko:K00058,ko:K16843 ko00260,ko00270,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00270,map00680,map01100,map01120,map01130,map01200,map01230 M00020 R01513,R05693 RC00031 ko00000,ko00001,ko00002,ko01000,ko04147 - - - 2-Hacid_dh,2-Hacid_dh_C,ACT k59_1379463_2 1166018.FAES_2129 4.76e-09 56.6 COG0251@1|root,COG0251@2|Bacteria,4NQAR@976|Bacteroidetes,47SC4@768503|Cytophagia 976|Bacteroidetes J Endoribonuclease L-PSP - - - - - - - - - - - - Ribonuc_L-PSP k59_23271_2 1499967.BAYZ01000184_gene4587 3.24e-44 157.0 COG4122@1|root,COG4122@2|Bacteria,2NQFB@2323|unclassified Bacteria 2|Bacteria S Pup-ligase protein dop GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0006464,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0010498,GO:0016787,GO:0016810,GO:0016811,GO:0017076,GO:0018193,GO:0018205,GO:0019538,GO:0019941,GO:0030163,GO:0030554,GO:0032446,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0036211,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0051603,GO:0070490,GO:0070647,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575 3.5.1.119 ko:K20814 - - - - ko00000,ko01000,ko03051 - - - Pup_ligase k59_1717900_1 640081.Dsui_2265 3.02e-24 101.0 COG0587@1|root,COG0587@2|Bacteria,1MUE4@1224|Proteobacteria,2VHCS@28216|Betaproteobacteria,2KUNR@206389|Rhodocyclales 206389|Rhodocyclales L DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase dnaE2 - 2.7.7.7 ko:K14162 - - - - ko00000,ko01000,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP k59_1717900_2 95619.PM1_0213410 6.36e-20 90.9 COG0389@1|root,COG0389@2|Bacteria,1MU5X@1224|Proteobacteria,1S28B@1236|Gammaproteobacteria 1236|Gammaproteobacteria L nucleotidyltransferase DNA polymerase involved in DNA repair imuB - - ko:K14161 - - - - ko00000,ko03400 - - - IMS k59_1152538_1 472759.Nhal_3413 2.06e-104 308.0 COG1611@1|root,COG1611@2|Bacteria,1MU6N@1224|Proteobacteria,1S032@1236|Gammaproteobacteria,1X250@135613|Chromatiales 135613|Chromatiales S Possible lysine decarboxylase - - 3.2.2.10 ko:K06966 ko00230,ko00240,map00230,map00240 - R00182,R00510 RC00063,RC00318 ko00000,ko00001,ko01000 - - - Lysine_decarbox k59_306255_2 1384056.N787_06945 1.41e-37 135.0 COG3175@1|root,COG3175@2|Bacteria,1RDTU@1224|Proteobacteria,1S5XA@1236|Gammaproteobacteria,1X5Z6@135614|Xanthomonadales 135614|Xanthomonadales O cytochrome c oxidase assembly protein cox11 - - ko:K02258 ko00190,ko01100,ko04714,map00190,map01100,map04714 M00154 - - ko00000,ko00001,ko00002,ko03029 3.D.4.8 - - CtaG_Cox11 k59_306255_3 322710.Avin_01010 4.14e-09 56.6 COG0843@1|root,COG0843@2|Bacteria,1MU7S@1224|Proteobacteria,1RPC3@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B ctaD - 1.9.3.1 ko:K02274,ko:K15408 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6 - iJN746.PP_0104 COX1 k59_248588_2 414684.RC1_2614 2.62e-38 141.0 COG2992@1|root,COG2992@2|Bacteria,1RD3U@1224|Proteobacteria,2U71B@28211|Alphaproteobacteria,2JS9D@204441|Rhodospirillales 204441|Rhodospirillales S FlgJ-related protein - - - ko:K03796 - - - - ko00000 - GH73 - Glucosaminidase k59_813188_1 1292373.H640_05505 1e-43 155.0 COG1181@1|root,COG1181@2|Bacteria,2GITC@201174|Actinobacteria,4DT59@85009|Propionibacteriales 201174|Actinobacteria M Belongs to the D-alanine--D-alanine ligase family ddl GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008716,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016874,GO:0016879,GO:0016881,GO:0030203,GO:0034645,GO:0040007,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044464,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 6.3.2.4 ko:K01921 ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502 - R01150 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Dala_Dala_lig_C,Dala_Dala_lig_N k59_23298_2 870187.Thini_2375 3.72e-50 160.0 COG3411@1|root,COG3411@2|Bacteria,1MZR4@1224|Proteobacteria,1S8U3@1236|Gammaproteobacteria,461G4@72273|Thiotrichales 72273|Thiotrichales C Ferredoxin - - - - - - - - - - - - 2Fe-2S_thioredx k59_306267_1 314345.SPV1_11756 5.19e-81 268.0 COG0479@1|root,COG0674@1|root,COG1013@1|root,COG1014@1|root,COG0479@2|Bacteria,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,1MVM0@1224|Proteobacteria 1224|Proteobacteria C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin nifJ - 1.2.7.1 ko:K03737 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00173,M00307 R01196,R10866 RC00004,RC02742 br01601,ko00000,ko00001,ko00002,ko01000 - - - EKR,Fer4,Fer4_16,Fer4_7,PFOR_II,POR,POR_N,TPP_enzyme_C k59_362937_1 911008.GLAD_00859 4.25e-73 247.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria 1236|Gammaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family mdtB GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 - ko:K07788 ko02020,map02020 M00648 - - ko00000,ko00001,ko00002,ko02000 2.A.6.2 - - ACR_tran k59_1492708_1 1123508.JH636447_gene7857 4.57e-21 106.0 COG2931@1|root,COG3291@1|root,COG2931@2|Bacteria,COG3291@2|Bacteria,2IZ0P@203682|Planctomycetes 203682|Planctomycetes Q Haemolysin-type calcium-binding repeat (2 copies) - - - - - - - - - - - - HemolysinCabind,Laminin_G_3 k59_643457_1 1245471.PCA10_p0040 1.02e-51 176.0 COG3039@1|root,COG3039@2|Bacteria,1MVDK@1224|Proteobacteria,1RR0T@1236|Gammaproteobacteria,1YD6I@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria L Transposase domain (DUF772) - - - ko:K07481 - - - - ko00000 - - - DDE_Tnp_1,DUF772 k59_362940_2 1453501.JELR01000001_gene3244 6.19e-60 193.0 COG0811@1|root,COG0811@2|Bacteria,1NXZ9@1224|Proteobacteria,1S154@1236|Gammaproteobacteria,465XD@72275|Alteromonadaceae 1236|Gammaproteobacteria U MotA/TolQ/ExbB proton channel family - - - - - - - - - - - - MotA_ExbB k59_1095525_1 1122137.AQXF01000007_gene3542 1.76e-201 576.0 COG4805@1|root,COG4805@2|Bacteria,1MUBX@1224|Proteobacteria,2TSUQ@28211|Alphaproteobacteria 1224|Proteobacteria O Protein conserved in bacteria - - - - - - - - - - - - DUF885 k59_80642_2 392499.Swit_3426 9.53e-05 45.4 COG1595@1|root,COG1595@2|Bacteria,1MX7T@1224|Proteobacteria,2U182@28211|Alphaproteobacteria,2KD1K@204457|Sphingomonadales 204457|Sphingomonadales K ECF sigma factor - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 k59_1605172_1 1122137.AQXF01000002_gene169 7.45e-106 318.0 COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,2TR8H@28211|Alphaproteobacteria 28211|Alphaproteobacteria C COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes lpd GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 1.8.1.4 ko:K00382 ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00036,M00307,M00532 R00209,R01221,R01698,R03815,R07618,R08549 RC00004,RC00022,RC00583,RC02742,RC02833,RC02834 br01601,ko00000,ko00001,ko00002,ko01000,ko04147 - - - Pyr_redox_2,Pyr_redox_dim k59_1095533_1 2340.JV46_16110 3.04e-85 280.0 COG0086@1|root,COG0086@2|Bacteria,1MU3M@1224|Proteobacteria,1RPYH@1236|Gammaproteobacteria,1J4ZQ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoC GO:0000428,GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0030880,GO:0032774,GO:0032991,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234 2.7.7.6 ko:K03046 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5 k59_306293_1 345073.VC395_0647 1.03e-19 90.1 COG0739@1|root,COG0739@2|Bacteria,1MVTF@1224|Proteobacteria,1RM7S@1236|Gammaproteobacteria,1XUZ4@135623|Vibrionales 135623|Vibrionales M COG0739 Membrane proteins related to metalloendopeptidases yebA - - - - - - - - - - - OapA,OapA_N,Peptidase_M23 k59_306293_2 582744.Msip34_0065 0.000595 43.9 COG2377@1|root,COG2377@2|Bacteria,1MV4E@1224|Proteobacteria,2VHCE@28216|Betaproteobacteria,2KMHH@206350|Nitrosomonadales 206350|Nitrosomonadales O Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling anmK - 2.7.1.170 ko:K09001 - - - - ko00000,ko01000 - - - AnmK k59_1152582_1 550540.Fbal_3739 6.14e-104 328.0 COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,1RNBG@1236|Gammaproteobacteria 1236|Gammaproteobacteria L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity polA GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008408,GO:0008409,GO:0009058,GO:0009059,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901362,GO:1901363,GO:1901576 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1 k59_587807_1 1391646.AVSU01000049_gene1622 4.84e-35 136.0 COG0633@1|root,COG3894@1|root,COG0633@2|Bacteria,COG3894@2|Bacteria,1TP0H@1239|Firmicutes,247S0@186801|Clostridia,25R30@186804|Peptostreptococcaceae 186801|Clostridia C Domain of unknown function (DUF4445) - - - - - - - - - - - - DUF4445,Fer2 k59_1440395_2 247633.GP2143_01460 1.35e-49 158.0 COG0186@1|root,COG0186@2|Bacteria,1MZIK@1224|Proteobacteria,1S8SS@1236|Gammaproteobacteria,1J6GF@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA rpsQ GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042221,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046677,GO:0050896,GO:0065003,GO:0070181,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02961 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S17 k59_1440395_3 1122194.AUHU01000017_gene1819 2.63e-09 53.1 COG0255@1|root,COG0255@2|Bacteria,1N6PR@1224|Proteobacteria,1SCBN@1236|Gammaproteobacteria,468D6@72275|Alteromonadaceae 1236|Gammaproteobacteria J Belongs to the universal ribosomal protein uL29 family rpmC GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02904 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L29 k59_932094_1 1279017.AQYJ01000027_gene1780 5.31e-151 431.0 COG0752@1|root,COG0752@2|Bacteria,1MVCJ@1224|Proteobacteria,1RMYI@1236|Gammaproteobacteria,4640E@72275|Alteromonadaceae 1236|Gammaproteobacteria J glycyl-tRNA synthetase alpha subunit glyQ GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 6.1.1.14 ko:K01878 ko00970,map00970 M00360 R03654 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iAF1260.b3560,iJO1366.b3560,iPC815.YPO4072,iY75_1357.Y75_RS19360 tRNA-synt_2e k59_1667691_1 1026882.MAMP_02029 2.21e-18 92.0 COG3249@1|root,COG3249@2|Bacteria,1N0PD@1224|Proteobacteria,1S9C4@1236|Gammaproteobacteria,461HX@72273|Thiotrichales 72273|Thiotrichales S protein conserved in bacteria - - - ko:K09938 - - - - ko00000 - - - DUF2066 k59_314897_1 1235457.C404_20220 1.47e-07 51.2 COG0607@1|root,COG0607@2|Bacteria,1MZ83@1224|Proteobacteria,2VU3D@28216|Betaproteobacteria,1K7Q4@119060|Burkholderiaceae 28216|Betaproteobacteria P PFAM Rhodanese domain protein glpE - 2.8.1.1,2.8.1.2 ko:K01011 ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122 - R01931,R03105,R03106 RC00214 ko00000,ko00001,ko01000 - - - Rhodanese k59_314897_2 1123354.AUDR01000014_gene964 3.76e-32 114.0 COG0695@1|root,COG0695@2|Bacteria,1N72P@1224|Proteobacteria,2VU2J@28216|Betaproteobacteria,1KRU8@119069|Hydrogenophilales 119069|Hydrogenophilales O Glutaredoxin - - - ko:K03676 - - - - ko00000,ko03110 - - - Glutaredoxin k59_424355_1 876044.IMCC3088_873 7.39e-103 318.0 COG2303@1|root,COG2303@2|Bacteria,1MU3F@1224|Proteobacteria,1RPBQ@1236|Gammaproteobacteria 1236|Gammaproteobacteria E COG2303 Choline dehydrogenase and related flavoproteins neoG - - - - - - - - - - - FAD_binding_2,GMC_oxred_C,GMC_oxred_N,NAD_binding_8 k59_1049142_1 1453501.JELR01000002_gene346 9.28e-71 221.0 COG0811@1|root,COG0811@2|Bacteria,1PKF8@1224|Proteobacteria,1RRWP@1236|Gammaproteobacteria,465RQ@72275|Alteromonadaceae 1236|Gammaproteobacteria U COG0811 Biopolymer transport proteins - - - - - - - - - - - - MotA_ExbB k59_650534_1 2340.JV46_27550 1.03e-68 216.0 arCOG03638@1|root,2Z8W3@2|Bacteria,1N2PH@1224|Proteobacteria,1RMI8@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Protein of unknown function (DUF1538) - - - - - - - - - - - - DUF1538 k59_762977_2 1265313.HRUBRA_01636 4.85e-30 116.0 COG4307@1|root,COG4307@2|Bacteria,1MW31@1224|Proteobacteria,1RRA7@1236|Gammaproteobacteria,1JA5V@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Putative zinc-binding metallo-peptidase - - - - - - - - - - - - Peptidase_Mx,zinc-ribbon_6 k59_372679_1 930169.B5T_01333 1.99e-62 218.0 COG4993@1|root,COG4993@2|Bacteria,1MUQX@1224|Proteobacteria,1RN5D@1236|Gammaproteobacteria,1XP1Y@135619|Oceanospirillales 135619|Oceanospirillales G beta-propeller repeat - - 1.1.5.8 ko:K05358 ko00400,ko01100,ko01110,ko01130,map00400,map01100,map01110,map01130 - R01873,R02415 RC00154,RC00206 ko00000,ko00001,ko01000 - - - PQQ k59_257973_1 13689.BV96_00392 1.52e-88 266.0 COG1010@1|root,COG1010@2|Bacteria,1MU79@1224|Proteobacteria,2TQJQ@28211|Alphaproteobacteria,2K0IF@204457|Sphingomonadales 204457|Sphingomonadales H Tetrapyrrole (Corrin/Porphyrin) Methylases cobJ - 2.1.1.131 ko:K05934 ko00860,ko01100,map00860,map01100 - R05180,R05809 RC00003,RC01293,RC03471 ko00000,ko00001,ko01000 - - - TP_methylase k59_1778906_1 938709.AUSH02000017_gene1055 1.08e-82 253.0 COG0714@1|root,COG0714@2|Bacteria,4NDVZ@976|Bacteroidetes 976|Bacteroidetes S ATPase family associated with various cellular activities (AAA) moxR - - ko:K03924 - - - - ko00000,ko01000 - - - AAA_3 k59_1778906_2 1137281.D778_01724 5.03e-43 149.0 2DKFZ@1|root,309D6@2|Bacteria,4NEGR@976|Bacteroidetes,1HZN8@117743|Flavobacteriia 976|Bacteroidetes S Domain of unknown function (DUF4382) - - - - - - - - - - - - CarboxypepD_reg,DUF4382 k59_820681_1 436308.Nmar_1768 3.01e-80 239.0 COG0589@1|root,arCOG02053@2157|Archaea,41T7V@651137|Thaumarchaeota 651137|Thaumarchaeota T Universal stress protein - - - - - - - - - - - - Usp k59_988658_1 316407.85674919 1.21e-155 460.0 COG0847@1|root,COG0847@2|Bacteria,1QWC0@1224|Proteobacteria,1T2TC@1236|Gammaproteobacteria,3XPTI@561|Escherichia 1236|Gammaproteobacteria L Is involved in the RecE pathway of recombination. Catalyzes the degradation of double-stranded DNA. Acts progressively in a 5' to 3' direction, releasing 5'- phosphomononucleotides. Has a strong preference for linear duplex substrate DNA and appears to be unable to initiate degradation from single-stranded breaks in DNA recE GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0005488,GO:0005515,GO:0006139,GO:0006259,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008309,GO:0008409,GO:0009987,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0034641,GO:0035312,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0051908,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360 - ko:K10906 - - - - ko00000,ko01000,ko03400 - - - DUF3799,Exonuc_VIII k59_710609_1 203122.Sde_0124 7.83e-64 202.0 COG1028@1|root,COG1028@2|Bacteria,1RHYX@1224|Proteobacteria,1S0GN@1236|Gammaproteobacteria,46D27@72275|Alteromonadaceae 1236|Gammaproteobacteria IQ COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - - - - - - - - - - - adh_short k59_650554_1 1121937.AUHJ01000008_gene2030 4.96e-108 318.0 COG0109@1|root,COG0109@2|Bacteria,1MW3S@1224|Proteobacteria,1RNHC@1236|Gammaproteobacteria,465UQ@72275|Alteromonadaceae 1236|Gammaproteobacteria O Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group cyoE GO:0003674,GO:0003824,GO:0004311,GO:0004659,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0015980,GO:0016020,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044464,GO:0045333,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.141 ko:K02257 ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714 M00154 R07411 RC01786 ko00000,ko00001,ko00002,ko01000,ko01006,ko03029 - - iJN746.PP_0110 UbiA k59_597436_1 1112214.AHIS01000101_gene1664 1.31e-32 129.0 COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2TR2W@28211|Alphaproteobacteria,2JZZB@204457|Sphingomonadales 204457|Sphingomonadales IQ COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II - - - - - - - - - - - - AMP-binding,AMP-binding_C k59_1441269_1 983920.Y88_1057 9.75e-104 313.0 COG0056@1|root,COG0056@2|Bacteria,1MUG7@1224|Proteobacteria,2TQYK@28211|Alphaproteobacteria,2K08A@204457|Sphingomonadales 204457|Sphingomonadales C Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit atpA - 3.6.3.14 ko:K02111 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - - ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N k59_1559459_2 1379270.AUXF01000007_gene865 6.22e-07 52.0 COG0115@1|root,COG0115@2|Bacteria,1ZTH5@142182|Gemmatimonadetes 142182|Gemmatimonadetes E Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family ilvE - 2.6.1.42 ko:K00826 ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00036,M00119,M00570 R01090,R01214,R02199,R10991 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_4 k59_932949_1 1238190.AMQY01000001_gene667 3.77e-16 74.3 arCOG10116@1|root,315E2@2|Bacteria,1MYJ7@1224|Proteobacteria,1SQ4Z@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_932949_2 1122137.AQXF01000004_gene1726 2.07e-123 365.0 COG1228@1|root,COG1228@2|Bacteria,1MVAF@1224|Proteobacteria,2TTYC@28211|Alphaproteobacteria 28211|Alphaproteobacteria Q COG1228 Imidazolonepropionase and related amidohydrolases - - - - - - - - - - - - Amidohydro_1 k59_33114_1 1121937.AUHJ01000017_gene3041 2.95e-97 300.0 COG0323@1|root,COG0323@2|Bacteria,1MV61@1224|Proteobacteria,1RM89@1236|Gammaproteobacteria,464TH@72275|Alteromonadaceae 1236|Gammaproteobacteria L This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex mutL GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - ko:K03572 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - DNA_mis_repair,HATPase_c_3,MutL_C k59_881080_1 1437882.AZRU01000020_gene6143 3.58e-124 375.0 COG0318@1|root,COG0318@2|Bacteria,1MWSD@1224|Proteobacteria,1RQ1C@1236|Gammaproteobacteria,1YIN3@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria IQ AMP-binding enzyme C-terminal domain - - 6.2.1.48 ko:K02182 - - - - ko00000,ko01000 - - - AMP-binding,AMP-binding_C k59_1441283_1 1216976.AX27061_0107 1.82e-124 365.0 COG1960@1|root,COG1960@2|Bacteria,1MU2V@1224|Proteobacteria,2VHBI@28216|Betaproteobacteria,3T36A@506|Alcaligenaceae 28216|Betaproteobacteria C Acyl-CoA dehydrogenase, C-terminal domain - - 1.3.8.7 ko:K00249 ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320 M00013,M00036,M00087 R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754 RC00052,RC00068,RC00076,RC00095,RC00148,RC00246 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_881090_1 316407.4062800 2.39e-180 535.0 COG5013@1|root,COG5013@2|Bacteria,1MW9S@1224|Proteobacteria,1RQ27@1236|Gammaproteobacteria,3XPE4@561|Escherichia 1236|Gammaproteobacteria C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family narG GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006082,GO:0006091,GO:0006807,GO:0008150,GO:0008152,GO:0008940,GO:0009055,GO:0009061,GO:0009325,GO:0009898,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0016661,GO:0019645,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0031235,GO:0032991,GO:0042126,GO:0043436,GO:0043546,GO:0044237,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0044799,GO:0045333,GO:0048037,GO:0050662,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0070469,GO:0070470,GO:0071704,GO:0071944,GO:0097159,GO:0098552,GO:0098562,GO:0098796,GO:0098797,GO:0098803,GO:1901363,GO:1902494,GO:1990204,GO:2001057 1.7.5.1 ko:K00370 ko00910,ko01120,ko02020,map00910,map01120,map02020 M00529,M00530,M00804 R00798,R01106,R09497 RC02812 ko00000,ko00001,ko00002,ko01000 5.A.3.1 - iSBO_1134.SBO_1842,iUMN146_1321.UM146_09685 Molybdopterin,Molydop_binding,Nitr_red_alph_N k59_372744_1 1429916.X566_01945 3.86e-14 75.5 COG0145@1|root,COG0145@2|Bacteria,1MU2Y@1224|Proteobacteria,2TQZ6@28211|Alphaproteobacteria,3JSA9@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria EQ Hydantoinase/oxoprolinase - - 3.5.2.14 ko:K01473 ko00330,ko01100,map00330,map01100 - R03187 RC00632 ko00000,ko00001,ko01000 - - - Hydant_A_N,Hydantoinase_A k59_710654_1 283942.IL2118 1.17e-75 242.0 COG0811@1|root,COG0811@2|Bacteria,1MX5J@1224|Proteobacteria,1RMSA@1236|Gammaproteobacteria,2QFST@267893|Idiomarinaceae 1236|Gammaproteobacteria U MotA/TolQ/ExbB proton channel family - - - ko:K03561 - - - - ko00000,ko02000 1.A.30.2.1 - - MotA_ExbB k59_1778944_1 314287.GB2207_09326 1.43e-61 196.0 COG0810@1|root,COG0810@2|Bacteria,1PEDH@1224|Proteobacteria,1RRNT@1236|Gammaproteobacteria,1J5VC@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria U Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins - - - ko:K03832 - - - - ko00000,ko02000 2.C.1.1 - - TonB_C k59_650581_1 614083.AWQR01000009_gene576 3.54e-26 103.0 COG0300@1|root,COG0300@2|Bacteria,1NGXF@1224|Proteobacteria,2VPF9@28216|Betaproteobacteria 28216|Betaproteobacteria S Short-chain dehydrogenase reductase (SDR) - - - - - - - - - - - - adh_short k59_650581_2 666681.M301_1239 7.76e-34 125.0 COG0702@1|root,COG0702@2|Bacteria,1PM6M@1224|Proteobacteria,2VMCW@28216|Betaproteobacteria 28216|Betaproteobacteria GM Nad-dependent epimerase dehydratase - - - - - - - - - - - - Epimerase k59_1389334_1 1122137.AQXF01000005_gene1356 2.04e-124 376.0 COG1450@1|root,COG1450@2|Bacteria,1MUUA@1224|Proteobacteria,2TT8A@28211|Alphaproteobacteria 28211|Alphaproteobacteria NU general secretion pathway protein D gspD - - ko:K02453 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - Secretin,Secretin_N k59_881101_2 933262.AXAM01000047_gene2343 1.28e-75 245.0 COG2252@1|root,COG2252@2|Bacteria,1MUV0@1224|Proteobacteria,42MAE@68525|delta/epsilon subdivisions,2WKFF@28221|Deltaproteobacteria,2MKCJ@213118|Desulfobacterales 28221|Deltaproteobacteria S Permease family pbuG - - ko:K06901 - - - - ko00000,ko02000 2.A.1.40 - - Xan_ur_permease k59_1161091_1 1229909.NSED_06760 1.37e-69 216.0 arCOG08689@1|root,arCOG08689@2157|Archaea,41T5U@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_33146_1 1122225.AULQ01000011_gene131 1.56e-06 50.8 COG1361@1|root,COG2152@1|root,COG1361@2|Bacteria,COG2152@2|Bacteria,4NMB8@976|Bacteroidetes,1HYNW@117743|Flavobacteriia 976|Bacteroidetes M C-terminal domain of CHU protein family - - - - - - - - - - - - CHU_C,DUF11,He_PIG,SdrD_B,SprB k59_33146_2 1197477.IA57_06600 1.78e-72 226.0 COG3064@1|root,COG3064@2|Bacteria,4NEVD@976|Bacteroidetes,1HXMP@117743|Flavobacteriia 976|Bacteroidetes M membrane - - - - - - - - - - - - PorP_SprF k59_881108_1 1122137.AQXF01000005_gene1302 2.44e-116 344.0 COG0151@1|root,COG0151@2|Bacteria,1MUAH@1224|Proteobacteria,2TQR5@28211|Alphaproteobacteria 28211|Alphaproteobacteria F Belongs to the GARS family purD - 6.3.4.13 ko:K01945 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04144 RC00090,RC00166 ko00000,ko00001,ko00002,ko01000 - - - GARS_A,GARS_C,GARS_N k59_1441308_1 330214.NIDE0781 9.84e-118 343.0 COG0462@1|root,COG0462@2|Bacteria,3J0D0@40117|Nitrospirae 40117|Nitrospirae F Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) prs - 2.7.6.1 ko:K00948 ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230 M00005 R01049 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - Pribosyl_synth,Pribosyltran_N k59_820743_1 686340.Metal_0996 6.32e-84 256.0 COG0152@1|root,COG0152@2|Bacteria,1MUR9@1224|Proteobacteria,1RNNY@1236|Gammaproteobacteria,1XDSQ@135618|Methylococcales 135618|Methylococcales F SAICAR synthetase purC - 6.3.2.6 ko:K01923 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04591 RC00064,RC00162 ko00000,ko00001,ko00002,ko01000 - - - SAICAR_synt k59_932981_2 6326.BUX.s00351.30 2.75e-07 57.4 COG0300@1|root,KOG1014@2759|Eukaryota,3AG87@33154|Opisthokonta,3BZ6Y@33208|Metazoa,3DEDD@33213|Bilateria,40FHW@6231|Nematoda,1KYQR@119089|Chromadorea 33208|Metazoa Q Enoyl-(Acyl carrier protein) reductase - - - - - - - - - - - - adh_short k59_1161106_1 867845.KI911784_gene2897 4.46e-18 89.4 COG0421@1|root,COG0421@2|Bacteria,2G80S@200795|Chloroflexi,37634@32061|Chloroflexia 32061|Chloroflexia E Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine - - - - - - - - - - - - - k59_597504_1 1197477.IA57_00820 2.13e-90 280.0 COG0760@1|root,COG0760@2|Bacteria,4NEW0@976|Bacteroidetes,1HXTE@117743|Flavobacteriia 976|Bacteroidetes O peptidyl-prolyl isomerase surA - 5.2.1.8 ko:K03771 - - - - ko00000,ko01000,ko03110 - - - Rotamase,SurA_N_3 k59_1328517_1 977880.RALTA_A2058 1.95e-61 197.0 COG0681@1|root,COG0681@2|Bacteria,1MXUF@1224|Proteobacteria,2VJ9D@28216|Betaproteobacteria,1K263@119060|Burkholderiaceae 28216|Betaproteobacteria U Belongs to the peptidase S26 family lepB - 3.4.21.89 ko:K03100 ko02024,ko03060,map02024,map03060 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_S24,Peptidase_S26 k59_1328517_2 653733.Selin_2225 4.26e-10 59.7 COG0481@1|root,COG0481@2|Bacteria 2|Bacteria M GTPase activity lepA GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0003824,GO:0003924,GO:0005488,GO:0005515,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0006950,GO:0006970,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009266,GO:0009268,GO:0009409,GO:0009628,GO:0009651,GO:0009987,GO:0010467,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019538,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034641,GO:0034645,GO:0035639,GO:0036094,GO:0042802,GO:0043021,GO:0043023,GO:0043024,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0050896,GO:0071704,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - ko:K03596 ko05134,map05134 - - - ko00000,ko00001 - - - EFG_C,GTP_EFTU,GTP_EFTU_D2,LepA_C k59_597507_1 640081.Dsui_1899 2.93e-18 82.8 COG0566@1|root,COG0566@2|Bacteria,1MWCM@1224|Proteobacteria,2VHF4@28216|Betaproteobacteria,2KV2Q@206389|Rhodocyclales 206389|Rhodocyclales J Specifically methylates the ribose of guanosine 2251 in 23S rRNA rlmB - 2.1.1.185 ko:K03218 - - - - ko00000,ko01000,ko03009 - - - SpoU_methylase,SpoU_sub_bind k59_597507_2 1121035.AUCH01000007_gene450 2.85e-61 208.0 COG0557@1|root,COG0557@2|Bacteria,1MUS6@1224|Proteobacteria,2VHBJ@28216|Betaproteobacteria,2KUXR@206389|Rhodocyclales 206389|Rhodocyclales J 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs rnr - - ko:K12573 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03016,ko03019 - - - OB_RNB,RNB,S1 k59_1668583_1 1288826.MSNKSG1_03086 1.77e-20 87.0 COG0233@1|root,COG0233@2|Bacteria,1N66T@1224|Proteobacteria,1RN75@1236|Gammaproteobacteria,466FX@72275|Alteromonadaceae 1236|Gammaproteobacteria J Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another frr GO:0002181,GO:0002184,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0022411,GO:0032984,GO:0034641,GO:0034645,GO:0043021,GO:0043023,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576 - ko:K02838 - - - - ko00000,ko03012 - - - RRF k59_1668583_2 1007105.PT7_1030 1.54e-27 106.0 COG0020@1|root,COG0020@2|Bacteria,1MVP1@1224|Proteobacteria,2VH2E@28216|Betaproteobacteria,3T293@506|Alcaligenaceae 28216|Betaproteobacteria H Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids uppS - 2.5.1.31 ko:K00806 ko00900,ko01110,map00900,map01110 - R06447 RC00279,RC02839 ko00000,ko00001,ko01000,ko01006 - - - Prenyltransf k59_1613856_1 1408433.JHXV01000020_gene3535 1.09e-20 98.2 COG1572@1|root,COG3266@1|root,COG1572@2|Bacteria,COG3266@2|Bacteria,4NQBS@976|Bacteroidetes,1I3X2@117743|Flavobacteriia 976|Bacteroidetes S FG-GAP repeat - - - - - - - - - - - - FG-GAP_2 k59_200421_1 886293.Sinac_7183 2.65e-66 211.0 COG1028@1|root,COG1028@2|Bacteria,2IYVF@203682|Planctomycetes 203682|Planctomycetes IQ COG1028 Dehydrogenases with different specificities (related - - 1.1.1.100 ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short,adh_short_C2 k59_1726458_1 469371.Tbis_1905 4.63e-111 337.0 COG0318@1|root,COG0318@2|Bacteria,2GJAA@201174|Actinobacteria,4DZE9@85010|Pseudonocardiales 201174|Actinobacteria IQ AMP-binding enzyme C-terminal domain - - - ko:K00666 - - - - ko00000,ko01000,ko01004 - - - AMP-binding,AMP-binding_C k59_820780_1 1123073.KB899241_gene2368 3.36e-40 153.0 COG1529@1|root,COG1529@2|Bacteria,1QTTJ@1224|Proteobacteria,1RNCM@1236|Gammaproteobacteria,1X5E5@135614|Xanthomonadales 135614|Xanthomonadales C Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL - - 1.3.99.16 ko:K07303 - - - - ko00000,ko01000 - - - Ald_Xan_dh_C,Ald_Xan_dh_C2 k59_597533_1 998674.ATTE01000001_gene4383 2.44e-34 130.0 COG1028@1|root,COG3347@1|root,COG1028@2|Bacteria,COG3347@2|Bacteria,1MWSB@1224|Proteobacteria,1RNTD@1236|Gammaproteobacteria 1236|Gammaproteobacteria IQ Class II Aldolase and Adducin N-terminal domain - - - - - - - - - - - - Aldolase_II,adh_short_C2 k59_597533_2 420324.KI912045_gene4483 2.17e-36 135.0 COG4952@1|root,COG4952@2|Bacteria,1PSSV@1224|Proteobacteria,2TSCI@28211|Alphaproteobacteria,1JXAW@119045|Methylobacteriaceae 28211|Alphaproteobacteria M isomerase rhaI - 5.3.1.14 ko:K01820 ko00040,ko00051,ko01120,map00040,map00051,map01120 - R01906,R02437,R06589 RC00376,RC00434,RC00516 ko00000,ko00001,ko01000 - - - AP_endonuc_2 k59_1271779_1 382464.ABSI01000006_gene852 5.44e-39 148.0 COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1144@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1144@2|Bacteria 2|Bacteria C oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor preT - 1.2.7.1 ko:K00171,ko:K03737 ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200 M00173,M00307,M00374,M00620 R01196,R01199,R08034,R10866 RC00004,RC00250,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - Fer4,Fer4_20,Fer4_6,PFOR_II,POR,POR_N,Pyr_redox_2,Pyr_redox_3,TPP_enzyme_C k59_1668604_1 595460.RRSWK_00987 8.19e-28 124.0 COG0642@1|root,COG1352@1|root,COG2201@1|root,COG2202@1|root,COG0642@2|Bacteria,COG1352@2|Bacteria,COG2201@2|Bacteria,COG2202@2|Bacteria,2IWSR@203682|Planctomycetes 203682|Planctomycetes NT catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR - - 2.1.1.80,3.1.1.61 ko:K13924 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko02022,ko02035 - - - CheB_methylest,CheR,CheR_N,HATPase_c,HisKA,PAS_10,PAS_4,PAS_9,Response_reg k59_1778986_1 485913.Krac_1649 7.99e-91 282.0 COG3385@1|root,COG3385@2|Bacteria 2|Bacteria L transposase activity - - - - - - - - - - - - DDE_5,DDE_Tnp_1_4 k59_258116_1 1038869.AXAN01000002_gene141 2e-26 110.0 COG0606@1|root,COG0606@2|Bacteria,1MU4R@1224|Proteobacteria,2VHRV@28216|Betaproteobacteria,1K45G@119060|Burkholderiaceae 28216|Betaproteobacteria O magnesium chelatase comM - - ko:K07391 - - - - ko00000 - - - ChlI,Mg_chelatase,Mg_chelatase_C k59_89850_2 1169143.KB911049_gene5652 0.000186 43.1 COG1024@1|root,COG1024@2|Bacteria,1Q51H@1224|Proteobacteria,2W0G8@28216|Betaproteobacteria,1KD1G@119060|Burkholderiaceae 28216|Betaproteobacteria I Enoyl-CoA hydratase/isomerase - - - - - - - - - - - - ECH_1 k59_536028_1 926569.ANT_19420 2.03e-69 238.0 COG2010@1|root,COG2010@2|Bacteria,2G741@200795|Chloroflexi 200795|Chloroflexi C Cytochrome c - - - - - - - - - - - - CarboxypepD_reg,Cytochrome_CBB3 k59_1389439_1 511062.GU3_02150 1.01e-26 110.0 COG3156@1|root,COG3156@2|Bacteria,1RJRE@1224|Proteobacteria,1S6CB@1236|Gammaproteobacteria 1236|Gammaproteobacteria U Type II secretion system protein K xpsK - - ko:K02460 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - T2SSK k59_1050353_1 1131269.AQVV01000003_gene762 2.14e-34 125.0 COG2077@1|root,COG2077@2|Bacteria 2|Bacteria O thioredoxin peroxidase activity tpx - 1.11.1.15 ko:K11065 - - - - ko00000,ko01000 - - - AhpC-TSA,Redoxin k59_1161181_1 1123059.KB823013_gene408 1.81e-14 71.6 COG1305@1|root,COG1305@2|Bacteria,1MVMI@1224|Proteobacteria,2TTZY@28211|Alphaproteobacteria,43W5B@69657|Hyphomonadaceae 28211|Alphaproteobacteria E COG1305 Transglutaminase-like enzymes MA20_32430 - - - - - - - - - - - Bact_transglu_N,Transglut_core k59_1161181_2 1144343.PMI41_01517 1.09e-106 313.0 COG3484@1|root,COG3484@2|Bacteria,1N057@1224|Proteobacteria,2U09K@28211|Alphaproteobacteria,43HIK@69277|Phyllobacteriaceae 28211|Alphaproteobacteria O Proteasome subunit MA20_32445 - - ko:K07395 - - - - ko00000 - - - Proteasome k59_1271812_1 1170562.Cal6303_0025 7.65e-85 266.0 COG5433@1|root,COG5433@2|Bacteria,1G2IT@1117|Cyanobacteria,1HREI@1161|Nostocales 1117|Cyanobacteria L transposase activity - - - - - - - - - - - - DDE_Tnp_1 k59_881212_2 398511.BpOF4_11115 2.02e-40 140.0 COG0500@1|root,COG2226@2|Bacteria 2|Bacteria Q methyltransferase - - - - - - - - - - - - Methyltransf_11,Methyltransf_25 k59_1218531_1 640081.Dsui_2462 8.14e-13 66.6 COG1381@1|root,COG1381@2|Bacteria,1RHIC@1224|Proteobacteria,2VJUC@28216|Betaproteobacteria,2KW9J@206389|Rhodocyclales 206389|Rhodocyclales L Involved in DNA repair and RecF pathway recombination recO - - ko:K03584 ko03440,map03440 - - - ko00000,ko00001,ko03400 - - - RecO_C,RecO_N k59_1218531_2 754477.Q7C_417 1.39e-56 187.0 COG1159@1|root,COG1159@2|Bacteria,1MUKT@1224|Proteobacteria,1RN3A@1236|Gammaproteobacteria,45ZSI@72273|Thiotrichales 72273|Thiotrichales S An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism era - - ko:K03595 - - - - ko00000,ko03009,ko03029 - - - KH_2,MMR_HSR1 k59_316217_2 765914.ThisiDRAFT_1057 4.14e-36 127.0 COG0386@1|root,COG0386@2|Bacteria,1RD1R@1224|Proteobacteria,1S425@1236|Gammaproteobacteria,1X0W3@135613|Chromatiales 135613|Chromatiales O Belongs to the glutathione peroxidase family - - - - - - - - - - - - GSHPx k59_425280_1 395495.Lcho_1404 7.98e-23 97.4 COG0535@1|root,COG0535@2|Bacteria,1MWDC@1224|Proteobacteria,2VJBQ@28216|Betaproteobacteria,1KK9D@119065|unclassified Burkholderiales 28216|Betaproteobacteria C Nitrogenase cofactor biosynthesis protein NifB nifB - - ko:K02585 - - - - ko00000 - - - Nitro_FeMo-Co,Radical_SAM k59_425280_2 187303.BN69_2618 2.38e-44 144.0 COG1145@1|root,COG1145@2|Bacteria,1MZ6H@1224|Proteobacteria,2UD9N@28211|Alphaproteobacteria,370C2@31993|Methylocystaceae 28211|Alphaproteobacteria C 4Fe-4S binding domain fdxN - - - - - - - - - - - Fer4 k59_1779024_1 1229909.NSED_03625 1.98e-45 157.0 arCOG04054@1|root,arCOG04054@2157|Archaea,41SIQ@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_33254_1 1385517.N800_07945 9.99e-58 196.0 COG2234@1|root,COG2234@2|Bacteria,1MWQ0@1224|Proteobacteria,1S1UU@1236|Gammaproteobacteria,1X439@135614|Xanthomonadales 135614|Xanthomonadales S peptidase - - - - - - - - - - - - Peptidase_M28 k59_33254_2 1380394.JADL01000002_gene1232 0.000436 46.2 COG0477@1|root,COG2814@2|Bacteria,1MW19@1224|Proteobacteria,2TRQD@28211|Alphaproteobacteria,2JZMC@204441|Rhodospirillales 204441|Rhodospirillales EGP Sugar (and other) transporter - - - ko:K07552 - - - - ko00000,ko02000 2.A.1.2 - - MFS_1 k59_933049_1 518766.Rmar_0228 1.63e-74 233.0 COG1999@1|root,COG1999@2|Bacteria,4NU1J@976|Bacteroidetes,1FJ7I@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes S signal sequence binding - - - ko:K07152 - - - - ko00000,ko03029 - - - SCO1-SenC k59_889961_2 1122137.AQXF01000006_gene858 5.58e-168 478.0 COG0795@1|root,COG0795@2|Bacteria,1MUF2@1224|Proteobacteria,2U55Q@28211|Alphaproteobacteria 28211|Alphaproteobacteria S YjgP YjgQ family - - - ko:K07091 ko02010,map02010 M00320 - - ko00000,ko00001,ko00002,ko02000 1.B.42.1 - - YjgP_YjgQ k59_1511034_2 436308.Nmar_0199 2.61e-30 108.0 arCOG10519@1|root,arCOG10519@2157|Archaea,41T6D@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1058243_1 1229909.NSED_09760 6.99e-100 295.0 COG0483@1|root,arCOG01349@2157|Archaea,41T8P@651137|Thaumarchaeota 651137|Thaumarchaeota G Inositol monophosphatase - - 3.1.3.25,3.1.3.7 ko:K01082,ko:K01092 ko00521,ko00562,ko00920,ko01100,ko01120,ko01130,ko04070,map00521,map00562,map00920,map01100,map01120,map01130,map04070 M00131 R00188,R00508,R01185,R01186,R01187 RC00078 ko00000,ko00001,ko00002,ko01000,ko03016 - - - Inositol_P k59_1058243_2 1229909.NSED_09755 2.41e-21 87.4 COG0529@1|root,arCOG01040@2157|Archaea 2157|Archaea F Catalyzes the synthesis of activated sulfate cysC - 2.7.1.25 ko:K00860,ko:K07028 ko00230,ko00920,ko01100,ko01120,map00230,map00920,map01100,map01120 M00176 R00509,R04928 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - AAA_33,APS_kinase k59_488436_1 103733.JNYO01000019_gene2044 1.78e-32 125.0 COG1191@1|root,COG1191@2|Bacteria,2GKBK@201174|Actinobacteria,4DZK1@85010|Pseudonocardiales 201174|Actinobacteria K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released whiG - - ko:K02405 ko02020,ko02025,ko02026,ko02040,ko05111,map02020,map02025,map02026,map02040,map05111 - - - ko00000,ko00001,ko02035,ko03021 - - - Sigma70_r2,Sigma70_r3,Sigma70_r4 k59_1449594_1 436308.Nmar_1242 5.68e-78 239.0 COG1630@1|root,arCOG00367@2157|Archaea,41SJX@651137|Thaumarchaeota 651137|Thaumarchaeota L NurA - - - - - - - - - - - - NurA k59_1621502_2 316057.RPD_4348 5.15e-28 108.0 COG1678@1|root,COG1678@2|Bacteria,1RCXM@1224|Proteobacteria,2TTX4@28211|Alphaproteobacteria,3JV81@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria K Belongs to the UPF0301 (AlgH) family MA20_18155 - - ko:K07735 - - - - ko00000,ko03000 - - - DUF179 k59_1398172_1 690850.Desaf_2629 1.16e-07 55.5 29MQ2@1|root,308MT@2|Bacteria,1NG1Y@1224|Proteobacteria,4365R@68525|delta/epsilon subdivisions,2X0PX@28221|Deltaproteobacteria,2MD1E@213115|Desulfovibrionales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_1786045_1 1122176.KB903554_gene3961 6.75e-69 231.0 COG1472@1|root,COG1472@2|Bacteria,4NE90@976|Bacteroidetes,1IR7S@117747|Sphingobacteriia 976|Bacteroidetes G Fibronectin type III-like domain bglB - 3.2.1.21 ko:K05349 ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110 - R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040 RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248 ko00000,ko00001,ko01000 - GH3 - Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C k59_1279534_1 861299.J421_2166 4.21e-38 146.0 COG1529@1|root,COG1529@2|Bacteria,1ZSUN@142182|Gemmatimonadetes 142182|Gemmatimonadetes C Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain - - 1.3.99.16 ko:K07303 - - - - ko00000,ko01000 - - - Ald_Xan_dh_C2 k59_1058264_1 1265313.HRUBRA_00220 1.18e-62 211.0 COG0477@1|root,COG2814@2|Bacteria,1MW59@1224|Proteobacteria,1RNUU@1236|Gammaproteobacteria 1236|Gammaproteobacteria EGP COG0477 Permeases of the major facilitator superfamily - - - - - - - - - - - - MFS_1 k59_1058264_2 402881.Plav_0954 5.49e-21 93.6 COG0665@1|root,COG0665@2|Bacteria,1MVGP@1224|Proteobacteria,2TT3Y@28211|Alphaproteobacteria,1JPUT@119043|Rhodobiaceae 28211|Alphaproteobacteria E FAD dependent oxidoreductase ordL - - - - - - - - - - - DAO k59_941069_1 1229909.NSED_02630 5.23e-102 304.0 COG1064@1|root,arCOG01455@2157|Archaea,41SA9@651137|Thaumarchaeota 651137|Thaumarchaeota C PFAM Alcohol dehydrogenase GroES-like domain - - 1.1.1.1 ko:K13953 ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220 - R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310 RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273 ko00000,ko00001,ko01000 - - - ADH_N,ADH_zinc_N k59_97544_1 319224.Sputcn32_3122 3.15e-40 144.0 COG0429@1|root,COG0429@2|Bacteria,1MWV1@1224|Proteobacteria,1RN39@1236|Gammaproteobacteria,2QAZU@267890|Shewanellaceae 1236|Gammaproteobacteria S PFAM alpha beta hydrolase fold yheT GO:0003674,GO:0003824,GO:0006629,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016788,GO:0044237,GO:0044238,GO:0044255,GO:0050526,GO:0052689,GO:0071704 - ko:K07019 - - - - ko00000 - - - Abhydrolase_1 k59_97544_2 765912.Thimo_0707 3.59e-83 267.0 COG1185@1|root,COG1185@2|Bacteria,1MVB9@1224|Proteobacteria,1RNBF@1236|Gammaproteobacteria,1WW27@135613|Chromatiales 135613|Chromatiales J Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction pnp - 2.7.7.8 ko:K00962 ko00230,ko00240,ko03018,map00230,map00240,map03018 M00394 R00437,R00438,R00439,R00440 RC02795 ko00000,ko00001,ko00002,ko01000,ko03016,ko03019 - - - KH_1,PNPase,RNase_PH,RNase_PH_C,S1 k59_606762_1 1026882.MAMP_00798 2.22e-14 77.8 COG0642@1|root,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,1T3XA@1236|Gammaproteobacteria,461JT@72273|Thiotrichales 72273|Thiotrichales T PAS fold - - - - - - - - - - - - HATPase_c,HisKA,PAS_9,Response_reg k59_381553_1 506534.Rhein_0997 3.11e-41 151.0 COG0021@1|root,COG0021@2|Bacteria,1MUEY@1224|Proteobacteria,1RMWP@1236|Gammaproteobacteria,1WVWH@135613|Chromatiales 135613|Chromatiales G Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate - - 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 - - - Transket_pyr,Transketolase_C,Transketolase_N k59_381553_2 1123253.AUBD01000005_gene176 6.16e-90 273.0 COG0057@1|root,COG0057@2|Bacteria,1MU93@1224|Proteobacteria,1RMBM@1236|Gammaproteobacteria,1X34S@135614|Xanthomonadales 135614|Xanthomonadales G Belongs to the glyceraldehyde-3-phosphate dehydrogenase family gapA - 1.2.1.12 ko:K00134 ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01061 RC00149 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - Gp_dh_C,Gp_dh_N k59_1279551_1 1265490.JHVY01000003_gene3073 8.09e-23 103.0 COG0863@1|root,COG0863@2|Bacteria 2|Bacteria L N-4 methylation of cytosine - - 2.1.1.72 ko:K00571 - - - - ko00000,ko01000,ko02048 - - - N6_N4_Mtase k59_1170075_1 5297.GMQ_11199T0 1.18e-33 130.0 COG0722@1|root,2QPSU@2759|Eukaryota,38CAA@33154|Opisthokonta,3NVDJ@4751|Fungi,3UZ8D@5204|Basidiomycota,2YC04@29000|Pucciniomycotina 4751|Fungi E Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) - - 2.5.1.54 ko:K01626 ko00400,ko01100,ko01110,ko01130,ko01230,ko02024,map00400,map01100,map01110,map01130,map01230,map02024 M00022 R01826 RC00435 ko00000,ko00001,ko00002,ko01000 - - - DAHP_synth_1 k59_1170075_2 1123034.JMKP01000031_gene1223 7.54e-44 157.0 COG0805@1|root,COG0805@2|Bacteria,1MVAY@1224|Proteobacteria,1RPRN@1236|Gammaproteobacteria,3NIT5@468|Moraxellaceae 1236|Gammaproteobacteria U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides tatC GO:0003674,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009314,GO:0009628,GO:0009977,GO:0015031,GO:0015291,GO:0015399,GO:0015405,GO:0015450,GO:0015833,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0022884,GO:0031224,GO:0031226,GO:0032991,GO:0033036,GO:0033281,GO:0034613,GO:0042802,GO:0042886,GO:0042887,GO:0043953,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0046907,GO:0050896,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0065002,GO:0070727,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0098796,GO:0098797,GO:1904680 - ko:K03118 ko03060,ko03070,map03060,map03070 M00336 - - ko00000,ko00001,ko00002,ko02044 2.A.64 - - TatC k59_432612_1 91604.ID47_06385 0.000808 46.6 COG0340@1|root,COG0340@2|Bacteria,1MWCC@1224|Proteobacteria,2TS82@28211|Alphaproteobacteria,47FFK@766|Rickettsiales 766|Rickettsiales H Biotin/lipoate A/B protein ligase family birA - 6.3.4.15 ko:K03524 ko00780,ko01100,map00780,map01100 - R01074,R05145 RC00043,RC00070,RC00096,RC02896 ko00000,ko00001,ko01000,ko03000 - - - BPL_C,BPL_LplA_LipB,BPL_LplA_LipB_2 k59_1621533_2 316274.Haur_3626 3.73e-08 60.8 COG1132@1|root,COG1132@2|Bacteria,2G5QH@200795|Chloroflexi,377YK@32061|Chloroflexia 32061|Chloroflexia P PFAM ABC transporter transmembrane region - - - ko:K06147 - - - - ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran k59_1336100_1 448385.sce0202 2.06e-79 263.0 COG1858@1|root,COG3391@1|root,COG1858@2|Bacteria,COG3391@2|Bacteria,1R66T@1224|Proteobacteria 1224|Proteobacteria C amine dehydrogenase activity - - - - - - - - - - - - - k59_996541_1 1396141.BATP01000030_gene3706 5.09e-51 182.0 COG0642@1|root,COG4251@1|root,COG2205@2|Bacteria,COG4251@2|Bacteria,46UHX@74201|Verrucomicrobia,2IVRU@203494|Verrucomicrobiae 203494|Verrucomicrobiae T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c k59_996543_1 247633.GP2143_01950 2.36e-32 119.0 2EZXX@1|root,33T24@2|Bacteria,1NQQH@1224|Proteobacteria 1224|Proteobacteria S Tellurite resistance protein TerB - - - - - - - - - - - - TerB k59_432639_1 795666.MW7_3332 1.08e-66 213.0 COG0391@1|root,COG0391@2|Bacteria,1NK78@1224|Proteobacteria,2VMUY@28216|Betaproteobacteria,1K5SP@119060|Burkholderiaceae 28216|Betaproteobacteria S Uncharacterised protein family UPF0052 - - 2.7.8.28 ko:K11212 ko00680,ko01120,map00680,map01120 M00378 R09398 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - UPF0052 k59_606805_2 344747.PM8797T_09624 6.71e-43 144.0 COG0139@1|root,COG0139@2|Bacteria,2J07K@203682|Planctomycetes 203682|Planctomycetes E Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP hisI - 3.5.4.19 ko:K01496 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04037 RC01055 ko00000,ko00001,ko00002,ko01000 - - - PRA-CH k59_41774_1 1385511.N783_16700 1.43e-18 89.0 COG0477@1|root,COG2814@2|Bacteria,1V1FR@1239|Firmicutes,4HGHP@91061|Bacilli 91061|Bacilli EGP MFS_1 like family - - - - - - - - - - - - MFS_1 k59_1676057_5 1499967.BAYZ01000197_gene3053 2.38e-156 464.0 COG4383@1|root,COG4383@2|Bacteria 2|Bacteria L Mu-like prophage protein gp29 - - - - - - - - - - - - DUF935 k59_1676057_6 1499967.BAYZ01000197_gene3052 9.23e-195 556.0 COG1783@1|root,COG1783@2|Bacteria 2|Bacteria S DNA packaging - - - - - - - - - - - - Terminase_6,Terminase_6C k59_941121_1 1265503.KB905177_gene3892 2.08e-95 294.0 COG4799@1|root,COG4799@2|Bacteria,1MVAX@1224|Proteobacteria,1RNV5@1236|Gammaproteobacteria,2Q64Y@267889|Colwelliaceae 1236|Gammaproteobacteria I Carboxyl transferase domain liuB - 6.4.1.4 ko:K01969 ko00280,ko01100,map00280,map01100 M00036 R04138 RC00367,RC00942 ko00000,ko00001,ko00002,ko01000 - - - Carboxyl_trans k59_1734154_2 633131.TR2A62_3489 2.34e-15 73.2 2C7KN@1|root,315J1@2|Bacteria,1PVP7@1224|Proteobacteria,2UIZD@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_381627_1 1242864.D187_008092 0.000606 47.8 COG1388@1|root,COG1388@2|Bacteria,1RIPY@1224|Proteobacteria,42TD8@68525|delta/epsilon subdivisions,2WPY2@28221|Deltaproteobacteria,2Z2U1@29|Myxococcales 28221|Deltaproteobacteria M Lysin motif - - - - - - - - - - - - LysM k59_996582_1 1096930.L284_02175 1.88e-76 242.0 COG0179@1|root,COG0179@2|Bacteria,1MW82@1224|Proteobacteria,2TRKH@28211|Alphaproteobacteria,2K0SS@204457|Sphingomonadales 204457|Sphingomonadales Q Fumarylacetoacetase - - 3.7.1.2 ko:K01555 ko00350,ko00643,ko01100,ko01120,map00350,map00643,map01100,map01120 M00044 R01364 RC00326,RC00446 ko00000,ko00001,ko00002,ko01000,ko04147 - - - FAA_hydrolase,FAA_hydrolase_N k59_1734164_1 96561.Dole_2484 2.58e-34 132.0 COG0739@1|root,COG0739@2|Bacteria,1MVTF@1224|Proteobacteria,42P5W@68525|delta/epsilon subdivisions,2WMA6@28221|Deltaproteobacteria,2MHP7@213118|Desulfobacterales 28221|Deltaproteobacteria M PFAM peptidase - - - - - - - - - - - - Peptidase_M23 k59_1110995_2 316067.Geob_3015 3.96e-56 183.0 COG1354@1|root,COG1354@2|Bacteria,1MVCN@1224|Proteobacteria,42RG5@68525|delta/epsilon subdivisions,2WNRE@28221|Deltaproteobacteria,43SVJ@69541|Desulfuromonadales 28221|Deltaproteobacteria D Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves scpA - - ko:K05896 - - - - ko00000,ko03036 - - - SMC_ScpA k59_1170126_1 1101195.Meth11DRAFT_0337 2.37e-69 215.0 COG0118@1|root,COG0118@2|Bacteria,1MU4X@1224|Proteobacteria,2VJPI@28216|Betaproteobacteria,2KKPZ@206350|Nitrosomonadales 206350|Nitrosomonadales E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR hisH - - ko:K02501 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04558 RC00010,RC01190,RC01943 ko00000,ko00001,ko00002,ko01000 - - - GATase k59_606851_1 543913.D521_1444 1.02e-45 149.0 COG1146@1|root,COG1146@2|Bacteria,1RH5I@1224|Proteobacteria,2VSJ0@28216|Betaproteobacteria,1KQ1A@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria C Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions fdxA - - ko:K05524 - - - - ko00000 - - - DUF3470,Fer4,Fer4_4 k59_606851_2 1392491.JIAE01000001_gene563 7.38e-11 58.5 COG3118@1|root,COG3118@2|Bacteria,1VA3Y@1239|Firmicutes,24MM5@186801|Clostridia,3WJVA@541000|Ruminococcaceae 186801|Clostridia O Belongs to the thioredoxin family - - - ko:K03671 ko04621,ko05418,map04621,map05418 - - - ko00000,ko00001,ko03110 - - - Thioredoxin k59_1279631_1 1232683.ADIMK_1447 0.000637 47.4 COG0617@1|root,COG0617@2|Bacteria,1MU2X@1224|Proteobacteria,1RPFJ@1236|Gammaproteobacteria,4641Q@72275|Alteromonadaceae 1236|Gammaproteobacteria J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate cca GO:0001680,GO:0003674,GO:0003824,GO:0004652,GO:0004810,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016437,GO:0016740,GO:0016772,GO:0016779,GO:0031123,GO:0034470,GO:0034641,GO:0034660,GO:0042245,GO:0042780,GO:0043170,GO:0043628,GO:0044237,GO:0044238,GO:0046483,GO:0070566,GO:0070567,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1990817 2.7.7.72 ko:K00974 ko03013,map03013 - R09382,R09383,R09384,R09386 RC00078 ko00000,ko00001,ko01000,ko03016 - - - HD,PolyA_pol,PolyA_pol_RNAbd k59_432707_2 1122137.AQXF01000003_gene2403 1.53e-85 258.0 COG0494@1|root,COG0494@2|Bacteria,1RD2C@1224|Proteobacteria,2TV3Q@28211|Alphaproteobacteria 28211|Alphaproteobacteria L COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes MA20_44635 - - - - - - - - - - - NUDIX k59_432707_3 1333998.M2A_2429 2.16e-33 123.0 COG3816@1|root,COG3816@2|Bacteria,1RD5Q@1224|Proteobacteria,2U7DA@28211|Alphaproteobacteria,4BQN8@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria S Protein of unknown function (DUF1285) MA20_44640 - - ko:K09986 - - - - ko00000 - - - DUF1285 k59_996604_1 863365.XHC_3467 2.43e-11 71.2 COG2909@1|root,COG2909@2|Bacteria,1MVZZ@1224|Proteobacteria,1RN29@1236|Gammaproteobacteria,1X3EM@135614|Xanthomonadales 135614|Xanthomonadales K transcriptional regulator acoK - - ko:K03556 - - - - ko00000,ko03000 - - - AAA_25,GerE,TPR_12 k59_1111004_1 436308.Nmar_0979 1.18e-81 251.0 COG1405@1|root,arCOG01981@2157|Archaea,41SXZ@651137|Thaumarchaeota 651137|Thaumarchaeota K Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB) - - - ko:K03124 ko03022,ko05169,ko05203,map03022,map05169,map05203 - - - ko00000,ko00001,ko03021 - - - TFIIB k59_432715_1 1123401.JHYQ01000022_gene1098 1.1e-106 322.0 COG1190@1|root,COG1190@2|Bacteria,1MX1V@1224|Proteobacteria,1RMJN@1236|Gammaproteobacteria,4608H@72273|Thiotrichales 72273|Thiotrichales J Belongs to the class-II aminoacyl-tRNA synthetase family lysS - 6.1.1.6 ko:K04567 ko00970,map00970 M00359,M00360 R03658 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_2,tRNA_anti-codon k59_1226087_2 266117.Rxyl_0632 1.09e-07 51.2 2DFSU@1|root,2ZT0P@2|Bacteria 2|Bacteria S Probable cobalt transporter subunit (CbtB) - - - - - - - - - - - - CbtB k59_1111010_1 1046625.AFQY01000002_gene1421 1.81e-14 71.6 COG0500@1|root,COG2226@2|Bacteria,1MX8I@1224|Proteobacteria,1RMAU@1236|Gammaproteobacteria,3NJ9G@468|Moraxellaceae 1236|Gammaproteobacteria H Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2- polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) ubiE GO:0003674,GO:0003824,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008425,GO:0008757,GO:0009058,GO:0009108,GO:0009233,GO:0009234,GO:0009987,GO:0016740,GO:0016741,GO:0030580,GO:0032259,GO:0042180,GO:0042181,GO:0043333,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901661,GO:1901663 2.1.1.163,2.1.1.201 ko:K03183 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116,M00117 R04990,R04993,R06859,R08774,R09736 RC00003,RC01253,RC01662 ko00000,ko00001,ko00002,ko01000 - - iAF1260.b3833,iBWG_1329.BWG_3511,iE2348C_1286.E2348C_4147,iEC042_1314.EC042_4213,iEC55989_1330.EC55989_4310,iECDH10B_1368.ECDH10B_4024,iECDH1ME8569_1439.ECDH1ME8569_3712,iECH74115_1262.ECH74115_5274,iECIAI1_1343.ECIAI1_4028,iECIAI39_1322.ECIAI39_3162,iECO103_1326.ECO103_4330,iECO111_1330.ECO111_4661,iECO26_1355.ECO26_4752,iECSE_1348.ECSE_4121,iECSP_1301.ECSP_4888,iECUMN_1333.ECUMN_4359,iECW_1372.ECW_m4135,iECs_1301.ECs4763,iEKO11_1354.EKO11_4524,iETEC_1333.ETEC_4110,iEcDH1_1363.EcDH1_4146,iEcE24377_1341.EcE24377A_4354,iEcHS_1320.EcHS_A4057,iEcSMS35_1347.EcSMS35_4216,iEcolC_1368.EcolC_4175,iG2583_1286.G2583_4633,iJO1366.b3833,iJR904.b3833,iSBO_1134.SBO_3847,iSDY_1059.SDY_3910,iSFV_1184.SFV_3665,iSF_1195.SF3911,iSFxv_1172.SFxv_4263,iSSON_1240.SSON_4008,iS_1188.S3843,iSbBS512_1146.SbBS512_E4305,iUMNK88_1353.UMNK88_4663,iWFL_1372.ECW_m4135,iY75_1357.Y75_RS17910,iZ_1308.Z5355 Ubie_methyltran k59_1111010_2 765912.Thimo_0056 4.04e-38 138.0 COG3165@1|root,COG3165@2|Bacteria,1R1CM@1224|Proteobacteria,1S1SM@1236|Gammaproteobacteria,1WWJP@135613|Chromatiales 135613|Chromatiales S Sterol-binding domain protein - - - ko:K03690 - - - - ko00000 - - - SCP2 k59_1058361_2 436308.Nmar_0953 2.81e-12 62.8 COG0346@1|root,arCOG02706@2157|Archaea,41SQS@651137|Thaumarchaeota 651137|Thaumarchaeota E Glyoxalase bleomycin resistance protein dioxygenase - - 5.1.99.1 ko:K05606 ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200 M00373,M00375,M00376,M00741 R02765,R09979 RC00780,RC02739 ko00000,ko00001,ko00002,ko01000 - - - Glyoxalase_4 k59_325051_1 1122137.AQXF01000002_gene293 5.33e-99 293.0 COG0413@1|root,COG0413@2|Bacteria,1MU3B@1224|Proteobacteria,2TQT1@28211|Alphaproteobacteria 28211|Alphaproteobacteria H Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate panB - 2.1.2.11 ko:K00606 ko00770,ko01100,ko01110,map00770,map01100,map01110 M00119 R01226 RC00022,RC00200 ko00000,ko00001,ko00002,ko01000 - - - Pantoate_transf k59_996625_2 1122225.AULQ01000007_gene2308 2.9e-70 224.0 COG0534@1|root,COG0534@2|Bacteria,4NEBB@976|Bacteroidetes,1HXAF@117743|Flavobacteriia 976|Bacteroidetes V Mate efflux family protein norM - - ko:K03327 - - - - ko00000,ko02000 2.A.66.1 - - MatE k59_1511173_1 582402.Hbal_2477 2.66e-13 77.0 COG4773@1|root,COG4773@2|Bacteria,1QTXJ@1224|Proteobacteria,2U0KK@28211|Alphaproteobacteria,43Z3W@69657|Hyphomonadaceae 28211|Alphaproteobacteria P TonB dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_1226803_2 1082933.MEA186_19802 5.71e-35 129.0 COG1409@1|root,COG1409@2|Bacteria,1MXD6@1224|Proteobacteria,2TSJ4@28211|Alphaproteobacteria,43ICX@69277|Phyllobacteriaceae 28211|Alphaproteobacteria S Calcineurin-like phosphoesterase superfamily domain - - - - - - - - - - - - Metallophos k59_941812_1 1282356.H045_16330 2.25e-16 82.0 COG3230@1|root,COG3230@2|Bacteria,1N9VG@1224|Proteobacteria,1S6DJ@1236|Gammaproteobacteria,1YQ6N@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria P Heme oxygenase bphO - - - - - - - - - - - Heme_oxygenase k59_941812_2 313612.L8106_21634 9.03e-07 49.7 COG4251@1|root,COG4251@2|Bacteria,1GHC4@1117|Cyanobacteria,1H8KS@1150|Oscillatoriales 1117|Cyanobacteria T Bacteriophytochrome (Light-regulated signal transduction histidine kinase) - - - - - - - - - - - - DUF3365,GAF,HATPase_c,HisKA,Hpt,PAS_2,PAS_3,PAS_9,PHY,Response_reg k59_1786995_1 436308.Nmar_0053 6.99e-123 360.0 COG1679@1|root,arCOG04278@2157|Archaea,41SBC@651137|Thaumarchaeota 651137|Thaumarchaeota S Protein of unknown function (DUF521) - - - ko:K09123 - - - - ko00000 - - - DUF521 k59_1786995_2 1229909.NSED_09900 9.34e-18 77.4 COG1786@1|root,arCOG04279@2157|Archaea,41SPA@651137|Thaumarchaeota 651137|Thaumarchaeota C Protein of unknown function DUF126 - - - ko:K09128 - - - - ko00000 - - - DUF126 k59_1450418_1 1122137.AQXF01000002_gene477 3.49e-26 107.0 COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2TR2W@28211|Alphaproteobacteria 28211|Alphaproteobacteria IQ COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II - - - - - - - - - - - - AMP-binding,AMP-binding_C k59_1450418_2 1122137.AQXF01000002_gene478 3.32e-63 203.0 COG1960@1|root,COG1960@2|Bacteria,1MUBH@1224|Proteobacteria,2TVBB@28211|Alphaproteobacteria 28211|Alphaproteobacteria I acyl-CoA dehydrogenase MA20_22775 - 1.3.8.7 ko:K00249 ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320 M00013,M00036,M00087 R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754 RC00052,RC00068,RC00076,RC00095,RC00148,RC00246 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_152683_1 377629.TERTU_1483 1.67e-12 72.8 COG3866@1|root,COG3866@2|Bacteria,1QPFF@1224|Proteobacteria,1RQEM@1236|Gammaproteobacteria,2PMMI@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria G Amb_all - - - - - - - - - - - - CBM_35,CBM_5_12_2,CBM_6,Pec_lyase_C,RicinB_lectin_2 k59_433723_1 1457393.AZ09_07475 1e-64 214.0 COG2317@1|root,COG2317@2|Bacteria,1MW7T@1224|Proteobacteria,2TSMY@28211|Alphaproteobacteria,2JP9Q@204441|Rhodospirillales 204441|Rhodospirillales E Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues - - 3.4.17.19 ko:K01299 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M32 k59_98439_2 641491.DND132_0696 1.16e-35 130.0 COG0560@1|root,COG0560@2|Bacteria,1MW38@1224|Proteobacteria,42PHG@68525|delta/epsilon subdivisions,2WPGN@28221|Deltaproteobacteria,2M8Y2@213115|Desulfovibrionales 28221|Deltaproteobacteria E haloacid dehalogenase-like hydrolase - - - - - - - - - - - - HAD k59_489429_1 1122137.AQXF01000003_gene2175 5.39e-59 183.0 COG2199@1|root,COG3706@2|Bacteria,1RH2K@1224|Proteobacteria,2U9EP@28211|Alphaproteobacteria 28211|Alphaproteobacteria T Response regulator receiver cheY - - ko:K03413 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko02022,ko02035 - - - Response_reg k59_489429_2 1122137.AQXF01000003_gene2174 3.93e-82 246.0 COG0835@1|root,COG0835@2|Bacteria,1RAH1@1224|Proteobacteria,2U59Y@28211|Alphaproteobacteria 28211|Alphaproteobacteria NT chemotaxis protein cheW - - ko:K03408 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - CheW k59_489429_3 1122137.AQXF01000003_gene2173 1.26e-61 210.0 COG0643@1|root,COG0643@2|Bacteria,1MUAG@1224|Proteobacteria,2TSN2@28211|Alphaproteobacteria 28211|Alphaproteobacteria T Histidine kinase cheA - 2.7.13.3 ko:K03407 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 - - - CheW,H-kinase_dim,HATPase_c,Hpt,Response_reg k59_217161_1 1415778.JQMM01000001_gene2018 1.56e-188 531.0 COG0077@1|root,COG1605@1|root,COG0077@2|Bacteria,COG1605@2|Bacteria,1MU60@1224|Proteobacteria,1RNRD@1236|Gammaproteobacteria,1J4I4@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E chorismate mutase pheA - 4.2.1.51,5.4.99.5 ko:K14170 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00024,M00025 R00691,R01373,R01715 RC00360,RC03116 ko00000,ko00001,ko00002,ko01000 - - - ACT,CM_2,PDT k59_1344233_1 436308.Nmar_1399 8.91e-87 277.0 arCOG08705@1|root,arCOG08705@2157|Archaea,41SXV@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1576658_1 1333507.AUTQ01000081_gene967 3.05e-11 70.1 COG3419@1|root,COG3419@2|Bacteria,1NUAV@1224|Proteobacteria,1RPV3@1236|Gammaproteobacteria,2PZUN@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria NU COG3419 Tfp pilus assembly protein, tip-associated adhesin PilY1 comC - - ko:K02674 - - - - ko00000,ko02035,ko02044 - - - Neisseria_PilC,VWA_2 k59_440873_1 1122137.AQXF01000001_gene3041 3.03e-139 414.0 COG0744@1|root,COG0744@2|Bacteria,1QTST@1224|Proteobacteria,2TQQ8@28211|Alphaproteobacteria 28211|Alphaproteobacteria M penicillin-binding protein pbpC - 2.4.1.129,3.4.16.4 ko:K05366 ko00550,ko01100,ko01501,map00550,map01100,map01501 - - - ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 - Transgly,Transpeptidase k59_1406817_1 317025.Tcr_0338 1.19e-95 291.0 COG1680@1|root,COG1680@2|Bacteria,1P3SQ@1224|Proteobacteria,1RRMI@1236|Gammaproteobacteria,462ZC@72273|Thiotrichales 72273|Thiotrichales V Beta-lactamase - - - - - - - - - - - - Beta-lactamase k59_105532_1 575540.Isop_3638 3.22e-104 315.0 COG1262@1|root,COG1262@2|Bacteria,2IXQ0@203682|Planctomycetes 203682|Planctomycetes S PFAM Formylglycine-generating sulfatase enzyme - - - - - - - - - - - - DZR,FGE-sulfatase,TPR_11 k59_667215_1 1229909.NSED_03085 7.87e-17 78.6 COG0530@1|root,arCOG02881@2157|Archaea,41T1S@651137|Thaumarchaeota 651137|Thaumarchaeota P Sodium/calcium exchanger protein - - - ko:K07301 - - - - ko00000,ko02000 2.A.19.5 - - Na_Ca_ex k59_667215_2 1229909.NSED_03080 3.67e-32 114.0 arCOG10530@1|root,arCOG10530@2157|Archaea,41T2M@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1344265_1 1379270.AUXF01000004_gene3301 5.53e-06 54.3 COG0457@1|root,COG4995@1|root,COG0457@2|Bacteria,COG4995@2|Bacteria 2|Bacteria S CHAT domain - - - - - - - - - - - - CHAT k59_551925_1 589873.EP13_17725 2.72e-74 245.0 COG1472@1|root,COG1472@2|Bacteria,1MVIV@1224|Proteobacteria,1RMA0@1236|Gammaproteobacteria,465BV@72275|Alteromonadaceae 1236|Gammaproteobacteria G Family 3 - - 3.2.1.21 ko:K05349 ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110 - R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040 RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248 ko00000,ko00001,ko01000 - GH3 - Glyco_hydro_3,Glyco_hydro_3_C k59_1004722_1 1045009.AFXQ01000014_gene526 3.63e-56 202.0 COG0474@1|root,COG0474@2|Bacteria,2GJJC@201174|Actinobacteria,1W8BP@1268|Micrococcaceae 201174|Actinobacteria P ATPase, P-type (transporting), HAD superfamily, subfamily IC ctpF GO:0003674,GO:0003824,GO:0005215,GO:0005388,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006816,GO:0008150,GO:0008324,GO:0015075,GO:0015085,GO:0015318,GO:0015399,GO:0015405,GO:0015662,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030001,GO:0030312,GO:0031224,GO:0031226,GO:0034220,GO:0042623,GO:0042625,GO:0042626,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043492,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0070588,GO:0070838,GO:0071944,GO:0072511,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0099131,GO:0099132 3.6.3.8 ko:K01537,ko:K12953 - - - - ko00000,ko01000 3.A.3,3.A.3.2 - - Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3 k59_1004722_2 925409.KI911562_gene2850 1.79e-29 111.0 COG2151@1|root,COG2151@2|Bacteria,4NSA9@976|Bacteroidetes,1ITW8@117747|Sphingobacteriia 976|Bacteroidetes S FeS assembly SUF system protein yitW - - - - - - - - - - - FeS_assembly_P k59_1004722_3 948106.AWZT01000053_gene1581 6.4e-52 169.0 COG0822@1|root,COG0822@2|Bacteria,1RD5K@1224|Proteobacteria,2VQ3A@28216|Betaproteobacteria,1K7JP@119060|Burkholderiaceae 28216|Betaproteobacteria C NifU-like N terminal domain - - - ko:K04488 - - - - ko00000 - - - NifU_N k59_1004722_4 948106.AWZT01000053_gene1580 2.48e-113 338.0 COG0520@1|root,COG0520@2|Bacteria,1MUPD@1224|Proteobacteria,2VIQW@28216|Betaproteobacteria,1K09J@119060|Burkholderiaceae 28216|Betaproteobacteria E Cysteine desulfurase sufS - 2.8.1.7,4.4.1.16 ko:K11717 ko00450,ko01100,map00450,map01100 - R03599,R11528 RC00961,RC01789,RC02313 ko00000,ko00001,ko01000 - - - Aminotran_5 k59_1344276_1 1229909.NSED_00210 1.22e-30 119.0 COG0252@1|root,arCOG01924@2157|Archaea,41SD7@651137|Thaumarchaeota 651137|Thaumarchaeota J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate gatD - 6.3.5.7 ko:K09482 ko00970,ko01100,map00970,map01100 - R03905 RC00010 ko00000,ko00001,ko01000 - - - Asparaginase k59_1344276_2 436308.Nmar_0101 6.38e-28 111.0 COG0464@1|root,arCOG01308@2157|Archaea,41SB6@651137|Thaumarchaeota 651137|Thaumarchaeota O Cell division protein 48 (CDC48), domain 2 - - - ko:K13525 ko04141,ko05134,map04141,map05134 M00400,M00403 - - ko00000,ko00001,ko00002,ko03019,ko04131,ko04147 3.A.16.1 - - AAA,CDC48_2,CDC48_N k59_1118802_1 1121033.AUCF01000005_gene5319 4.83e-27 117.0 COG0709@1|root,COG1252@1|root,COG0709@2|Bacteria,COG1252@2|Bacteria,1MWFG@1224|Proteobacteria,2TR91@28211|Alphaproteobacteria,2JV91@204441|Rhodospirillales 204441|Rhodospirillales CE AIR synthase related protein, C-terminal domain - - - - - - - - - - - - AIRS,AIRS_C,Pyr_redox_2 k59_1118809_1 477184.KYC_08800 2.28e-75 236.0 COG1960@1|root,COG1960@2|Bacteria,1MX17@1224|Proteobacteria,2VM2C@28216|Betaproteobacteria,3T6AI@506|Alcaligenaceae 28216|Betaproteobacteria C Acyl-CoA dehydrogenase, C-terminal domain - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_1118809_2 1123072.AUDH01000007_gene1132 2.71e-20 93.2 COG1042@1|root,COG1042@2|Bacteria,1MW98@1224|Proteobacteria,2TR24@28211|Alphaproteobacteria 28211|Alphaproteobacteria C COG1042 Acyl-CoA synthetase (NDP forming) - - - - - - - - - - - - ATP-grasp_5,CoA_binding_2,Succ_CoA_lig k59_667238_1 1429916.X566_16140 1.54e-78 245.0 COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,2TSA0@28211|Alphaproteobacteria,3JQM2@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria I Belongs to the thiolase family MA20_06750 - 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N k59_275205_1 1380600.AUYN01000001_gene2513 3.11e-107 317.0 COG0117@1|root,COG1985@1|root,COG0117@2|Bacteria,COG1985@2|Bacteria,4NFJE@976|Bacteroidetes,1HX8D@117743|Flavobacteriia 976|Bacteroidetes H Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate ribD - 1.1.1.193,3.5.4.26 ko:K11752 ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024 M00125 R03458,R03459 RC00204,RC00933 ko00000,ko00001,ko00002,ko01000 - - - RibD_C,dCMP_cyt_deam_1 k59_1233532_1 440512.C211_11402 2.97e-78 257.0 COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,1RSC1@1236|Gammaproteobacteria 1236|Gammaproteobacteria IQ COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II - - - - - - - - - - - - AMP-binding,AMP-binding_C k59_1519213_1 1122137.AQXF01000004_gene1845 2.2e-99 299.0 COG0527@1|root,COG0527@2|Bacteria,1MW3H@1224|Proteobacteria,2TRFA@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Belongs to the aspartokinase family lysC GO:0003674,GO:0003824,GO:0004072,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006553,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0019202,GO:0019752,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046451,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.2.4 ko:K00928 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00017,M00018,M00033,M00525,M00526,M00527 R00480 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase,ACT,ACT_7 k59_728326_1 1265505.ATUG01000001_gene3625 1.86e-52 172.0 COG0745@1|root,COG0745@2|Bacteria,1MU3A@1224|Proteobacteria,42S73@68525|delta/epsilon subdivisions,2WNPE@28221|Deltaproteobacteria,2MPTJ@213118|Desulfobacterales 28221|Deltaproteobacteria T Transcriptional regulatory protein, C terminal - - - - - - - - - - - - Response_reg,Trans_reg_C k59_49692_1 1415780.JPOG01000001_gene3097 3.51e-05 48.5 COG5395@1|root,COG5395@2|Bacteria,1N0CF@1224|Proteobacteria,1SB8K@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Predicted membrane protein (DUF2306) - - - - - - - - - - - - DUF2306 k59_160040_1 1122137.AQXF01000004_gene1758 1.71e-148 430.0 COG0019@1|root,COG0019@2|Bacteria,1MZ7Y@1224|Proteobacteria,2TSKB@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Belongs to the Orn Lys Arg decarboxylase class-II family ldc - 4.1.1.17 ko:K01581 ko00330,ko00480,ko01100,ko01110,ko01130,map00330,map00480,map01100,map01110,map01130 M00134 R00670 RC00299 ko00000,ko00001,ko00002,ko01000 - - - Orn_Arg_deC_N,Orn_DAP_Arg_deC k59_898355_1 1121904.ARBP01000036_gene2106 1.37e-06 55.5 COG1524@1|root,COG4099@1|root,COG4733@1|root,COG1524@2|Bacteria,COG4099@2|Bacteria,COG4733@2|Bacteria,4NK2V@976|Bacteroidetes 976|Bacteroidetes O Fibronectin type III domain protein - - - - - - - - - - - - Laminin_G_3,PA14,fn3 k59_667262_1 326297.Sama_2300 7.22e-16 81.6 COG5000@1|root,COG5000@2|Bacteria,1QUG9@1224|Proteobacteria,1T1Y1@1236|Gammaproteobacteria,2Q92R@267890|Shewanellaceae 1236|Gammaproteobacteria T PAS PAC sensor signal transduction histidine kinase flrB - 2.7.13.3 ko:K10942 ko02020,ko05111,map02020,map05111 M00515 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA,PAS,PAS_8 k59_898367_1 1122137.AQXF01000001_gene2756 3.79e-25 100.0 COG0583@1|root,COG0583@2|Bacteria,1MWY0@1224|Proteobacteria,2TSD9@28211|Alphaproteobacteria 28211|Alphaproteobacteria K Transcriptional regulator - GO:0001130,GO:0001131,GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009411,GO:0009416,GO:0009628,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031326,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1903506,GO:2000112,GO:2001141 - ko:K03566 ko02026,map02026 - - - ko00000,ko00001,ko03000 - - - HTH_1,LysR_substrate k59_898367_2 1122137.AQXF01000001_gene2755 5.74e-61 193.0 COG0175@1|root,COG0175@2|Bacteria,1MXUR@1224|Proteobacteria,2U5AP@28211|Alphaproteobacteria 28211|Alphaproteobacteria EH Reduction of activated sulfate into sulfite cysH - 1.8.4.10,1.8.4.8 ko:K00390 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00176 R02021 RC00007,RC02862 ko00000,ko00001,ko00002,ko01000 - - - PAPS_reduct k59_1233554_1 1229909.NSED_09590 1.79e-22 89.4 arCOG08808@1|root,arCOG08808@2157|Archaea,41T95@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1233554_2 1229909.NSED_09595 9.09e-32 123.0 COG0459@1|root,arCOG01257@2157|Archaea,41SDG@651137|Thaumarchaeota 651137|Thaumarchaeota O PFAM TCP-1 cpn60 chaperonin family - - - ko:K22447 - - - - ko00000,ko03110 - - - Cpn60_TCP1 k59_778545_1 936455.KI421499_gene4168 9.75e-29 122.0 COG2203@1|root,COG4191@1|root,COG2203@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TTJ0@28211|Alphaproteobacteria,3JS5D@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria T Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - - - - - - - - - - GAF,GAF_2,HAMP,HATPase_c,HisKA,PAS_7,dCache_1 k59_49707_1 391625.PPSIR1_35797 2.25e-55 192.0 COG1752@1|root,COG1752@2|Bacteria,1PEH4@1224|Proteobacteria,42XKH@68525|delta/epsilon subdivisions,2WTA6@28221|Deltaproteobacteria,2YWD2@29|Myxococcales 28221|Deltaproteobacteria S Patatin-like phospholipase - - - ko:K07001 - - - - ko00000 - - - Patatin k59_496375_1 1229909.NSED_03085 5.23e-52 172.0 COG0530@1|root,arCOG02881@2157|Archaea,41T1S@651137|Thaumarchaeota 651137|Thaumarchaeota P Sodium/calcium exchanger protein - - - ko:K07301 - - - - ko00000,ko02000 2.A.19.5 - - Na_Ca_ex k59_1794288_1 926569.ANT_06590 6.21e-82 251.0 COG2199@1|root,COG3706@2|Bacteria,2G85T@200795|Chloroflexi 200795|Chloroflexi T Response regulator receiver - - - - - - - - - - - - GGDEF,Response_reg k59_949182_1 1163617.SCD_n01709 2.41e-72 219.0 COG1734@1|root,COG1734@2|Bacteria,1RD08@1224|Proteobacteria,2VRPJ@28216|Betaproteobacteria 28216|Betaproteobacteria T Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters dksA - - ko:K06204 ko02026,map02026 - - - ko00000,ko00001,ko03000,ko03009,ko03021 - - - zf-dskA_traR k59_160085_1 1122137.AQXF01000002_gene407 1.57e-181 529.0 COG0013@1|root,COG0013@2|Bacteria,1MU9A@1224|Proteobacteria,2TQV4@28211|Alphaproteobacteria 28211|Alphaproteobacteria J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain alaS GO:0003674,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016597,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.7 ko:K01872 ko00970,map00970 M00359,M00360 R03038 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DHHA1,tRNA-synt_2c,tRNA_SAD k59_160085_2 402881.Plav_2578 2.13e-141 408.0 COG0468@1|root,COG0468@2|Bacteria,1MU3C@1224|Proteobacteria,2TRPR@28211|Alphaproteobacteria,1JNJM@119043|Rhodobiaceae 28211|Alphaproteobacteria L Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage recA GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716,GO:0071496 - ko:K03553 ko03440,map03440 M00729 - - ko00000,ko00001,ko00002,ko03400 - - - RecA k59_1066033_1 697282.Mettu_0093 2.62e-43 152.0 COG0136@1|root,COG0136@2|Bacteria,1MUHG@1224|Proteobacteria,1RNB6@1236|Gammaproteobacteria,1XDRT@135618|Methylococcales 135618|Methylococcales E Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate asd - 1.2.1.11 ko:K00133 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00017,M00018,M00033,M00525,M00526,M00527 R02291 RC00684 ko00000,ko00001,ko00002,ko01000 - - - Semialdhyde_dh,Semialdhyde_dhC k59_1684779_1 1484460.JSWG01000009_gene704 4.7e-07 49.3 COG0666@1|root,COG0666@2|Bacteria,4NSDC@976|Bacteroidetes,1I46H@117743|Flavobacteriia 976|Bacteroidetes S Ankyrin repeat - - - - - - - - - - - - Ank_2,Ank_3,Ank_4,Ank_5 k59_1684779_2 745718.JADT01000014_gene152 1.34e-49 163.0 COG3340@1|root,COG3340@2|Bacteria,4NEXW@976|Bacteroidetes,1HXTK@117743|Flavobacteriia 976|Bacteroidetes E Belongs to the peptidase S51 family pepE - 3.4.13.21 ko:K05995 - - - - ko00000,ko01000,ko01002 - - - Peptidase_S51 k59_949720_1 1123393.KB891316_gene1837 2.65e-62 207.0 COG0007@1|root,COG1648@1|root,COG0007@2|Bacteria,COG1648@2|Bacteria,1MUI0@1224|Proteobacteria,2VICS@28216|Betaproteobacteria,1KSAQ@119069|Hydrogenophilales 119069|Hydrogenophilales H Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme cysG - 1.3.1.76,2.1.1.107,4.99.1.4 ko:K02302 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R02864,R03194,R03947 RC00003,RC00871,RC01012,RC01034 ko00000,ko00001,ko00002,ko01000 - - - CysG_dimeriser,NAD_binding_7,Sirohm_synth_M,TP_methylase k59_390672_1 394221.Mmar10_2175 3.34e-13 67.4 COG0625@1|root,COG0625@2|Bacteria,1RA4M@1224|Proteobacteria,2TV0I@28211|Alphaproteobacteria 28211|Alphaproteobacteria O Glutathione S-transferase - - 2.5.1.18 ko:K00799 ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418 - R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905 RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944 ko00000,ko00001,ko01000,ko02000 1.A.12.2.2,1.A.12.3.2 - - GST_C,GST_C_2,GST_N,GST_N_3 k59_390672_2 563192.HMPREF0179_05251 2.87e-06 48.1 COG1476@1|root,COG1476@2|Bacteria 2|Bacteria K sequence-specific DNA binding - - - - - - - - - - - - HTH_3 k59_160664_1 886293.Sinac_5749 1.72e-16 79.7 COG0243@1|root,COG0243@2|Bacteria,2IXW2@203682|Planctomycetes 203682|Planctomycetes C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - 1.7.7.2 ko:K00367,ko:K00372 ko00910,ko01120,map00910,map01120 M00531 R00791,R00798,R01106 RC02812 ko00000,ko00001,ko00002,ko01000 - - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding k59_898909_1 512565.AMIS_31020 4.1e-72 236.0 COG0659@1|root,COG0659@2|Bacteria,2GJCB@201174|Actinobacteria 201174|Actinobacteria P Sulfate transporter - - - ko:K03321 - - - - ko00000,ko02000 2.A.53.3 - - STAS,Sulfate_transp k59_898914_1 1499967.BAYZ01000057_gene4735 1.88e-30 122.0 COG0420@1|root,COG0420@2|Bacteria,2NQ16@2323|unclassified Bacteria 2|Bacteria L SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'- 5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity sbcD - - ko:K03546,ko:K03547 - - - - ko00000,ko03400 - - - Metallophos k59_217842_1 641526.ADIWIN_0210 7.52e-108 331.0 COG1472@1|root,COG1472@2|Bacteria,4NE90@976|Bacteroidetes,1HX27@117743|Flavobacteriia 976|Bacteroidetes G Belongs to the glycosyl hydrolase 3 family bglX - 3.2.1.21 ko:K05349 ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110 - R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040 RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248 ko00000,ko00001,ko01000 - GH3 - Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C k59_1066631_1 366602.Caul_4457 4.02e-53 170.0 COG3324@1|root,COG3324@2|Bacteria,1NH40@1224|Proteobacteria,2UNJU@28211|Alphaproteobacteria 28211|Alphaproteobacteria E translation initiation factor activity - - - ko:K06996 - - - - ko00000 - - - - k59_333521_2 373903.Hore_18160 5.33e-47 161.0 COG0664@1|root,COG0664@2|Bacteria,1VD7I@1239|Firmicutes,25MZK@186801|Clostridia,3WBXH@53433|Halanaerobiales 186801|Clostridia K PFAM Bacterial regulatory proteins, crp family - - - ko:K10914 ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111 - - - ko00000,ko00001,ko03000 - - - HTH_Crp_2,cNMP_binding k59_333521_3 1038860.AXAP01000038_gene3724 7.59e-48 167.0 COG1004@1|root,COG1004@2|Bacteria,1MW5U@1224|Proteobacteria,2TREV@28211|Alphaproteobacteria,3JTIE@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria M Belongs to the UDP-glucose GDP-mannose dehydrogenase family rkpK GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 1.1.1.22 ko:K00012 ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100 M00014,M00129,M00361,M00362 R00286 RC00291 ko00000,ko00001,ko00002,ko01000 - - - UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N k59_1630159_1 1117647.M5M_10945 4.38e-13 67.0 COG2859@1|root,COG2859@2|Bacteria,1QU0K@1224|Proteobacteria,1RR22@1236|Gammaproteobacteria,1J6ZJ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Protein of unknown function (DUF541) - - - ko:K09797 - - - - ko00000 - - - SIMPL k59_1630159_2 1042377.AFPJ01000054_gene1715 3.94e-83 265.0 COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,1MUJ3@1224|Proteobacteria,1RRN4@1236|Gammaproteobacteria,4674P@72275|Alteromonadaceae 1236|Gammaproteobacteria EU Prolyl oligopeptidase, N-terminal beta-propeller domain - - - - - - - - - - - - PD40,Peptidase_S9,Peptidase_S9_N k59_50280_1 1122137.AQXF01000002_gene82 1.33e-112 329.0 COG0730@1|root,COG0730@2|Bacteria,1R3V4@1224|Proteobacteria,2TRYX@28211|Alphaproteobacteria 28211|Alphaproteobacteria S membrane transporter protein MA20_43555 - - ko:K07090 - - - - ko00000 - - - TauE k59_949749_1 1265503.KB905162_gene3579 1.69e-14 78.6 COG0642@1|root,COG0642@2|Bacteria,1MX6R@1224|Proteobacteria,1T213@1236|Gammaproteobacteria,2Q600@267889|Colwelliaceae 1236|Gammaproteobacteria T GHKL domain - - 2.7.13.3 ko:K07637 ko01503,ko02020,map01503,map02020 M00444,M00709,M00721,M00723,M00724,M00744 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko01504,ko02022 - - - HATPase_c k59_496941_1 1121004.ATVC01000010_gene1049 7.39e-25 97.4 COG0233@1|root,COG0233@2|Bacteria,1N66T@1224|Proteobacteria,2VIUA@28216|Betaproteobacteria,2KQ85@206351|Neisseriales 206351|Neisseriales J Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another frr - - ko:K02838 - - - - ko00000,ko03012 - - - RRF k59_496941_2 666681.M301_1314 2.57e-66 207.0 COG0528@1|root,COG0528@2|Bacteria,1MV3N@1224|Proteobacteria,2VH8A@28216|Betaproteobacteria,2KKZ6@206350|Nitrosomonadales 206350|Nitrosomonadales F Catalyzes the reversible phosphorylation of UMP to UDP pyrH - 2.7.4.22 ko:K09903 ko00240,ko01100,map00240,map01100 - R00158 RC00002 ko00000,ko00001,ko01000 - - - AA_kinase k59_1685414_1 87626.PTD2_18715 1.12e-18 84.7 COG1609@1|root,COG1609@2|Bacteria,1MW7E@1224|Proteobacteria,1RNKJ@1236|Gammaproteobacteria,2Q08A@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria K COG1609 Transcriptional regulators - - - ko:K02529 - - - - ko00000,ko03000 - - - LacI,Peripla_BP_3 k59_1685414_2 1300345.LF41_1067 1.1e-76 245.0 COG2211@1|root,COG2211@2|Bacteria,1MX4Z@1224|Proteobacteria,1RRNW@1236|Gammaproteobacteria,1X5B8@135614|Xanthomonadales 135614|Xanthomonadales G Major facilitator superfamily - - - ko:K16211 - - - - ko00000,ko02000 2.A.2.6 - - MFS_1 k59_1794855_2 436308.Nmar_0924 1.13e-33 121.0 COG0558@1|root,arCOG00670@2157|Archaea,41SJ7@651137|Thaumarchaeota 651137|Thaumarchaeota I Belongs to the CDP-alcohol phosphatidyltransferase class-I family - - 2.7.8.39 ko:K17884 - - R10464 RC00002,RC00078 ko00000,ko01000 - - - CDP-OH_P_transf k59_1742471_1 1121948.AUAC01000002_gene1706 4.09e-71 227.0 COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,2TQQ7@28211|Alphaproteobacteria,43W8U@69657|Hyphomonadaceae 28211|Alphaproteobacteria I Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation - - 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N k59_1742471_3 1122137.AQXF01000002_gene366 8.94e-43 148.0 COG3000@1|root,COG3000@2|Bacteria,1NR7X@1224|Proteobacteria,2TT68@28211|Alphaproteobacteria 28211|Alphaproteobacteria I COG3000 Sterol desaturase - - - - - - - - - - - - FA_hydroxylase k59_949753_1 1250005.PHEL85_0475 3.8e-57 182.0 COG0071@1|root,COG0071@2|Bacteria,4NQXY@976|Bacteroidetes,1I382@117743|Flavobacteriia 976|Bacteroidetes O Belongs to the small heat shock protein (HSP20) family - - - ko:K13993 ko04141,map04141 - - - ko00000,ko00001,ko03110 - - - HSP20 k59_1178362_1 316407.1800048 8.37e-71 224.0 COG0160@1|root,COG0160@2|Bacteria,1MWY6@1224|Proteobacteria,1RMP0@1236|Gammaproteobacteria,3XNUA@561|Escherichia 1236|Gammaproteobacteria E Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family gabT GO:0001505,GO:0003674,GO:0003824,GO:0003867,GO:0003992,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006576,GO:0006591,GO:0006595,GO:0006598,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009056,GO:0009058,GO:0009063,GO:0009064,GO:0009084,GO:0009308,GO:0009310,GO:0009445,GO:0009447,GO:0009448,GO:0009450,GO:0009987,GO:0016053,GO:0016054,GO:0016740,GO:0016769,GO:0019752,GO:0019842,GO:0030170,GO:0032787,GO:0034641,GO:0036094,GO:0042133,GO:0042135,GO:0042402,GO:0042450,GO:0043167,GO:0043168,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046395,GO:0048037,GO:0050662,GO:0065007,GO:0065008,GO:0070279,GO:0071704,GO:0072329,GO:0097159,GO:0097164,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901607 2.6.1.19,2.6.1.22,2.6.1.48 ko:K00823,ko:K07250,ko:K14268 ko00250,ko00280,ko00310,ko00410,ko00640,ko00650,ko01100,ko01120,map00250,map00280,map00310,map00410,map00640,map00650,map01100,map01120 M00027 R00908,R01648,R02274,R04188 RC00006,RC00062,RC00160 ko00000,ko00001,ko00002,ko01000,ko01007 - - iEC55989_1330.EC55989_2930,iECIAI1_1343.ECIAI1_2758,iECO111_1330.ECO111_3386,iECO26_1355.ECO26_3731,iSFxv_1172.SFxv_1480,iS_1188.S1389 Aminotran_3 k59_779120_1 396588.Tgr7_0843 1.79e-15 79.7 COG4137@1|root,COG4137@2|Bacteria,1R3YD@1224|Proteobacteria,1RPUQ@1236|Gammaproteobacteria,1WX1P@135613|Chromatiales 135613|Chromatiales S Cytochrome c assembly protein - - - - - - - - - - - - Cytochrom_C_asm k59_779120_2 314287.GB2207_10803 1.75e-62 205.0 COG0541@1|root,COG0541@2|Bacteria,1MVIA@1224|Proteobacteria,1RMU9@1236|Gammaproteobacteria,1J4KT@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components ffh GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006605,GO:0006612,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0032991,GO:0033036,GO:0034613,GO:0035639,GO:0036094,GO:0042886,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0045184,GO:0046907,GO:0048500,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0070727,GO:0071702,GO:0071705,GO:0072657,GO:0090150,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1990904 3.6.5.4 ko:K03106 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko01000,ko02044 3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9 - - SRP54,SRP54_N,SRP_SPB k59_1577425_1 59538.XP_005978265.1 3.08e-86 260.0 COG0588@1|root,KOG0235@2759|Eukaryota,38GF6@33154|Opisthokonta,3BA4I@33208|Metazoa,3CVWK@33213|Bilateria,485KR@7711|Chordata,49041@7742|Vertebrata,3J3S8@40674|Mammalia,4J696@91561|Cetartiodactyla 33208|Metazoa G phosphoglycerate mutase - - 5.4.2.11 ko:K01834 ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko05230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map05230 M00001,M00002,M00003 R01518 RC00536 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - His_Phos_1 k59_217869_1 452637.Oter_4049 1.36e-119 363.0 COG0661@1|root,COG0661@2|Bacteria,46UJV@74201|Verrucomicrobia,3K7NS@414999|Opitutae 414999|Opitutae S ABC1 family - - - ko:K03688 - - - - ko00000 - - - ABC1 k59_1577436_1 1305737.JAFX01000001_gene2927 6.56e-79 251.0 COG4147@1|root,COG4147@2|Bacteria,4NHPT@976|Bacteroidetes,47JSK@768503|Cytophagia 976|Bacteroidetes S Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family actP - - ko:K14393 - - - - ko00000,ko02000 2.A.21.7 - - SSF k59_1577436_2 237727.NAP1_15758 3.54e-35 122.0 COG4327@1|root,COG4327@2|Bacteria 2|Bacteria S Domain of unknown function (DUF4212) - - - - - - - - - - - - DUF4212 k59_949769_1 983920.Y88_3535 1.36e-108 337.0 COG0495@1|root,COG0495@2|Bacteria,1MV47@1224|Proteobacteria,2TQPK@28211|Alphaproteobacteria,2K0Q0@204457|Sphingomonadales 204457|Sphingomonadales J Belongs to the class-I aminoacyl-tRNA synthetase family leuS - 6.1.1.4 ko:K01869 ko00970,map00970 M00359,M00360 R03657 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - Anticodon_1,tRNA-synt_1,tRNA-synt_1_2 k59_1005444_1 1303518.CCALI_02718 4.44e-35 135.0 COG1331@1|root,COG1331@2|Bacteria 2|Bacteria O Highly conserved protein containing a thioredoxin domain yyaL - - ko:K06888 - - - - ko00000 - - - GlcNAc_2-epim,Thioredox_DsbH k59_615708_1 857087.Metme_2909 3.31e-55 179.0 COG2078@1|root,COG2078@2|Bacteria,1RJP4@1224|Proteobacteria,1S6FG@1236|Gammaproteobacteria,1XF04@135618|Methylococcales 135618|Methylococcales S pfam ammecr1 - - - - - - - - - - - - AMMECR1 k59_57876_1 1116472.MGMO_122c00240 4.74e-62 194.0 COG0041@1|root,COG0041@2|Bacteria,1RCWJ@1224|Proteobacteria,1S3VN@1236|Gammaproteobacteria,1XF1U@135618|Methylococcales 135618|Methylococcales F Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) purE - 5.4.99.18 ko:K01588 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R07405 RC01947 ko00000,ko00001,ko00002,ko01000 - - - AIRC k59_57876_2 744872.Spica_2463 5.07e-10 59.3 COG0026@1|root,COG0026@2|Bacteria,2JA8G@203691|Spirochaetes 203691|Spirochaetes F Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) purK - 6.3.4.18 ko:K01589 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R07404 RC01927 ko00000,ko00001,ko00002,ko01000 - - - ATP-grasp k59_1244125_1 314278.NB231_09828 1.15e-49 176.0 COG5421@1|root,COG5421@2|Bacteria,1R3NX@1224|Proteobacteria,1RQBI@1236|Gammaproteobacteria 1236|Gammaproteobacteria L PFAM Transposase - - - - - - - - - - - - DDE_Tnp_1 k59_283939_1 983920.Y88_0018 2.96e-60 186.0 COG0278@1|root,COG0278@2|Bacteria,1MZ4V@1224|Proteobacteria,2U9QB@28211|Alphaproteobacteria,2K55Y@204457|Sphingomonadales 204457|Sphingomonadales O Belongs to the glutaredoxin family. Monothiol subfamily - - - - - - - - - - - - Glutaredoxin k59_283939_2 555793.WSK_1777 1.01e-18 77.8 COG0271@1|root,COG0271@2|Bacteria 2|Bacteria T Belongs to the BolA IbaG family colA - - - - - - - - - - - BolA k59_227200_1 436308.Nmar_0714 2.76e-55 186.0 arCOG00373@1|root,arCOG00373@2157|Archaea,41ST8@651137|Thaumarchaeota 651137|Thaumarchaeota L ATPase involved in DNA repair - - - - - - - - - - - - - k59_453047_1 1120963.KB894502_gene1361 7.76e-52 177.0 COG3004@1|root,COG3004@2|Bacteria,1MW15@1224|Proteobacteria,1RNDE@1236|Gammaproteobacteria,2Q26G@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria P ) H( ) antiporter that extrudes sodium in exchange for external protons nhaA - - ko:K03313 - - - - ko00000,ko02000 2.A.33.1 - - Na_H_antiport_1 k59_453047_2 326424.FRAAL5646 9.15e-06 47.8 COG0609@1|root,COG0609@2|Bacteria,2GK8Z@201174|Actinobacteria,4EVCR@85013|Frankiales 201174|Actinobacteria P Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily fecD - - ko:K02015 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko02000 3.A.1.14 - - FecCD k59_114275_1 1229909.NSED_00425 7.41e-50 177.0 COG0642@1|root,arCOG02358@2157|Archaea 2157|Archaea T Histidine kinase - - - - - - - - - - - - HATPase_c,HisKA k59_1752515_1 323261.Noc_0373 1.55e-49 176.0 COG0751@1|root,COG0751@2|Bacteria,1MV2F@1224|Proteobacteria,1RNR3@1236|Gammaproteobacteria,1WWSJ@135613|Chromatiales 135613|Chromatiales J Glycyl-tRNA synthetase beta subunit glyS - 6.1.1.14 ko:K01879 ko00970,map00970 M00360 R03654 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DALR_1,tRNA_synt_2f k59_170840_2 1279017.AQYJ01000029_gene3711 5.95e-58 200.0 COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,1MV6G@1224|Proteobacteria,1RMYD@1236|Gammaproteobacteria,4643G@72275|Alteromonadaceae 1236|Gammaproteobacteria E Methionine synthase metH GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006464,GO:0006479,GO:0006520,GO:0006555,GO:0006575,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0008213,GO:0008270,GO:0008276,GO:0008652,GO:0008705,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0019538,GO:0019752,GO:0019842,GO:0031419,GO:0032259,GO:0034641,GO:0035999,GO:0036094,GO:0036211,GO:0042084,GO:0042558,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043414,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046653,GO:0046872,GO:0046906,GO:0046914,GO:0048037,GO:0050667,GO:0051186,GO:0071704,GO:0097159,GO:0140096,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.1.1.13 ko:K00548 ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230 M00017 R00946,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 - - iECO103_1326.ECO103_4764,iECUMN_1333.ECUMN_4545 B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans k59_566330_1 584708.Apau_2360 4e-54 192.0 COG1866@1|root,COG1866@2|Bacteria,3TA0Q@508458|Synergistetes 508458|Synergistetes H Belongs to the phosphoenolpyruvate carboxykinase (ATP) family - - 4.1.1.49 ko:K01610 ko00010,ko00020,ko00620,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00710,map01100,map01110,map01120,map01130,map01200 M00003,M00170 R00341 RC00002,RC02741 ko00000,ko00001,ko00002,ko01000 - - - PEPCK_ATP k59_792339_1 1229909.NSED_00145 2.38e-133 391.0 COG1599@1|root,arCOG01510@2157|Archaea,41S9M@651137|Thaumarchaeota 651137|Thaumarchaeota L COG1599 Single-stranded DNA-binding replication protein A (RPA), large (70 kD) subunit and related ssDNA-binding proteins - - - ko:K07466 ko03030,ko03420,ko03430,ko03440,ko03460,map03030,map03420,map03430,map03440,map03460 M00288 - - ko00000,ko00001,ko00002,ko03000,ko03032,ko03400 - - - - k59_396720_1 95619.PM1_0221860 9.1e-23 95.9 COG2834@1|root,COG2834@2|Bacteria,1PXDV@1224|Proteobacteria,1S9FW@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) lolA GO:0002790,GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0006810,GO:0008104,GO:0008150,GO:0008565,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0030288,GO:0030313,GO:0031975,GO:0032940,GO:0033036,GO:0034613,GO:0042597,GO:0042886,GO:0042953,GO:0042954,GO:0044464,GO:0044872,GO:0044873,GO:0044874,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0051641,GO:0070727,GO:0071702,GO:0071705,GO:0072321,GO:0072322,GO:0072323,GO:0072657 - ko:K03634 - - - - ko00000 - - - LolA k59_396720_2 1134474.O59_002289 9.02e-83 266.0 COG1674@1|root,COG1674@2|Bacteria,1MVPI@1224|Proteobacteria,1RM9A@1236|Gammaproteobacteria,1FGW9@10|Cellvibrio 1236|Gammaproteobacteria D Ftsk_gamma ftsK GO:0000920,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006355,GO:0006950,GO:0006970,GO:0007059,GO:0008094,GO:0008150,GO:0009628,GO:0009651,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0015616,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019219,GO:0019222,GO:0031224,GO:0031226,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0033676,GO:0042221,GO:0042623,GO:0042802,GO:0043085,GO:0043565,GO:0044093,GO:0044425,GO:0044459,GO:0044464,GO:0045893,GO:0045935,GO:0046677,GO:0048518,GO:0048522,GO:0050789,GO:0050790,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051301,GO:0051716,GO:0060255,GO:0065007,GO:0065009,GO:0070887,GO:0071236,GO:0071944,GO:0080090,GO:0097159,GO:0140097,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141 - ko:K03466 - - - - ko00000,ko03036 3.A.12 - - FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma k59_792344_1 987059.RBXJA2T_09257 2.15e-18 85.1 COG0543@1|root,COG1018@1|root,COG0543@2|Bacteria,COG1018@2|Bacteria,1MV72@1224|Proteobacteria,2VI9K@28216|Betaproteobacteria,1KK9J@119065|unclassified Burkholderiales 28216|Betaproteobacteria C Oxidoreductase FAD-binding domain ascD - 1.17.1.1 ko:K00523 ko00520,map00520 - R03391,R03392 RC00230 ko00000,ko00001,ko01000 - - - FAD_binding_6,Fer2,NAD_binding_1 k59_1413602_1 1411685.U062_00937 3.77e-09 57.0 COG0625@1|root,COG0625@2|Bacteria,1MWUG@1224|Proteobacteria 1224|Proteobacteria O Glutathione S-transferase gst - 2.5.1.18 ko:K00799 ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418 - R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905 RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944 ko00000,ko00001,ko01000,ko02000 1.A.12.2.2,1.A.12.3.2 - - GST_C,GST_C_3,GST_N,GST_N_3 k59_1413602_2 1207055.C100_16790 9.49e-53 175.0 COG0179@1|root,COG0179@2|Bacteria,1MV0V@1224|Proteobacteria,2TQYU@28211|Alphaproteobacteria,2K2VH@204457|Sphingomonadales 204457|Sphingomonadales Q COG0179 2-keto-4-pentenoate hydratase 2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) - - 3.7.1.2 ko:K16171 ko00350,ko00643,ko01100,ko01120,map00350,map00643,map01100,map01120 M00044 R01364 RC00326,RC00446 ko00000,ko00001,ko00002,ko01000 - - - FAA_hydrolase k59_848726_1 748247.AZKH_p0385 3.58e-50 165.0 COG1853@1|root,COG1853@2|Bacteria,1MUPP@1224|Proteobacteria,2W9SW@28216|Betaproteobacteria,2KZ7W@206389|Rhodocyclales 206389|Rhodocyclales S Flavin reductase like domain - - - - - - - - - - - - Flavin_Reduct k59_792348_1 1430440.MGMSRv2_0110 4.9e-51 182.0 COG0439@1|root,COG1984@1|root,COG2049@1|root,COG4770@1|root,COG0439@2|Bacteria,COG1984@2|Bacteria,COG2049@2|Bacteria,COG4770@2|Bacteria,1MU4H@1224|Proteobacteria,2TRU5@28211|Alphaproteobacteria,2JUXR@204441|Rhodospirillales 204441|Rhodospirillales EI Allophanate hydrolase subunit 1 - - 6.3.4.6 ko:K01941 ko00220,ko00791,ko01100,map00220,map00791,map01100 - R00774 RC00378 ko00000,ko00001,ko01000 - - - Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2,CT_A_B,CT_C_D k59_1639575_1 1229909.NSED_08160 1.63e-17 77.8 arCOG08637@1|root,arCOG08637@2157|Archaea,41SV0@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1639575_2 436308.Nmar_1479 9.98e-71 221.0 COG0214@1|root,arCOG04075@2157|Archaea,41SEJ@651137|Thaumarchaeota 651137|Thaumarchaeota H Belongs to the PdxS SNZ family - - 4.3.3.6 ko:K06215 ko00750,map00750 - R07456 RC00010,RC01783,RC03043 ko00000,ko00001,ko01000 - - - SOR_SNZ k59_622613_1 1254432.SCE1572_49275 3.55e-194 563.0 COG0243@1|root,COG0243@2|Bacteria,1NS3T@1224|Proteobacteria,42M9Q@68525|delta/epsilon subdivisions 1224|Proteobacteria C nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC narB - - ko:K00372 ko00910,ko01120,map00910,map01120 M00531 R00798,R01106 RC02812 ko00000,ko00001,ko00002,ko01000 - - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding k59_1357181_1 511145.b1688 1.75e-56 185.0 COG0628@1|root,COG0628@2|Bacteria,1MVX7@1224|Proteobacteria,1RNN1@1236|Gammaproteobacteria,3XM9X@561|Escherichia 1236|Gammaproteobacteria S transporter activity ydiK GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944 - - - - - - - - - - AI-2E_transport k59_283988_2 1280948.HY36_16065 1.1e-32 123.0 COG4795@1|root,COG4795@2|Bacteria,1N942@1224|Proteobacteria,2UHZB@28211|Alphaproteobacteria,43YIR@69657|Hyphomonadaceae 28211|Alphaproteobacteria U Type II secretion system (T2SS), protein J - - - ko:K02459 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - N_methyl,T2SSJ k59_283988_3 1524467.IV04_24070 4.1e-37 142.0 COG3156@1|root,COG3156@2|Bacteria,1RAQM@1224|Proteobacteria,1S2N8@1236|Gammaproteobacteria,401AT@613|Serratia 1236|Gammaproteobacteria U Type II secretion system protein K gspK GO:0002790,GO:0006810,GO:0008104,GO:0008150,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0032940,GO:0033036,GO:0042886,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0071702,GO:0071705 - ko:K02460 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - T2SSK k59_1696068_1 645991.Sgly_0878 3.87e-05 53.5 COG5263@1|root,COG5263@2|Bacteria,1UYJ9@1239|Firmicutes,25KQ1@186801|Clostridia,26562@186807|Peptococcaceae 186801|Clostridia N domain protein - - - - - - - - - - - - SLH k59_396746_1 1117314.PCIT_09649 1.04e-10 68.6 COG0474@1|root,COG0474@2|Bacteria,1QWMC@1224|Proteobacteria,1T25Y@1236|Gammaproteobacteria 1236|Gammaproteobacteria P Domain of unknown function (DUF4153) - - - - - - - - - - - - DUF4153,DUF4173 k59_567638_1 426117.M446_5648 2.21e-64 216.0 COG0145@1|root,COG0145@2|Bacteria,1MU2Y@1224|Proteobacteria,2TQZ6@28211|Alphaproteobacteria,1JUGP@119045|Methylobacteriaceae 28211|Alphaproteobacteria EQ PFAM Hydantoinase oxoprolinase - - 3.5.2.14 ko:K01473 ko00330,ko01100,map00330,map01100 - R03187 RC00632 ko00000,ko00001,ko01000 - - - Hydant_A_N,Hydantoinase_A k59_1188831_1 227377.CBU_0500 7.71e-08 53.5 COG0470@1|root,COG0470@2|Bacteria,1MY1W@1224|Proteobacteria,1RNYA@1236|Gammaproteobacteria,1JCXJ@118969|Legionellales 118969|Legionellales L DNA polymerase III, delta subunit holB - 2.7.7.7 ko:K02341 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_delta2,DNApol3-delta_C k59_1188831_2 314285.KT71_15429 1.64e-48 162.0 COG0125@1|root,COG0125@2|Bacteria,1MV9C@1224|Proteobacteria,1S26C@1236|Gammaproteobacteria,1J7UM@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria F Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis tmk GO:0003674,GO:0003824,GO:0004798,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006220,GO:0006221,GO:0006227,GO:0006233,GO:0006235,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009165,GO:0009186,GO:0009189,GO:0009196,GO:0009197,GO:0009200,GO:0009202,GO:0009211,GO:0009212,GO:0009219,GO:0009221,GO:0009262,GO:0009263,GO:0009265,GO:0009394,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019692,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046072,GO:0046075,GO:0046077,GO:0046385,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.4.9 ko:K00943 ko00240,ko01100,map00240,map01100 M00053 R02094,R02098 RC00002 ko00000,ko00001,ko00002,ko01000 - - iECABU_c1320.ECABU_c13120,ic_1306.c1370 Thymidylate_kin k59_510813_1 1279009.ADICEAN_02355 0.000328 48.1 2EHX5@1|root,33BNR@2|Bacteria,4NXNQ@976|Bacteroidetes 976|Bacteroidetes - - - - - - - - - - - - - - - k59_285186_1 1177179.A11A3_04955 1.49e-81 254.0 COG2227@1|root,COG2227@2|Bacteria,1NN3B@1224|Proteobacteria,1T1TQ@1236|Gammaproteobacteria,1XHUZ@135619|Oceanospirillales 135619|Oceanospirillales J Catalyzes carboxymethyl transfer from carboxy-S- adenosyl-L-methionine (Cx-SAM) to 5-hydroxyuridine (ho5U) to form 5-carboxymethoxyuridine (cmo5U) at position 34 in tRNAs cmoB - - ko:K15257 - - - - ko00000,ko01000,ko03016 - - - Methyltransf_9 k59_341634_1 519989.ECTPHS_11010 9.92e-62 203.0 COG1160@1|root,COG1160@2|Bacteria,1MU9S@1224|Proteobacteria,1RMSF@1236|Gammaproteobacteria,1WVW6@135613|Chromatiales 135613|Chromatiales S GTPase that plays an essential role in the late steps of ribosome biogenesis der - - ko:K03977 - - - - ko00000,ko03009 - - - KH_dom-like,MMR_HSR1 k59_341634_2 391615.ABSJ01000029_gene1936 1.86e-07 52.4 COG2981@1|root,COG2981@2|Bacteria,1MVFT@1224|Proteobacteria,1RMQT@1236|Gammaproteobacteria,1J5RJ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria U High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway cysZ GO:0000096,GO:0000097,GO:0000103,GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006082,GO:0006520,GO:0006534,GO:0006790,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0008150,GO:0008152,GO:0008271,GO:0008272,GO:0008324,GO:0008509,GO:0008512,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009675,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015103,GO:0015116,GO:0015291,GO:0015293,GO:0015294,GO:0015295,GO:0015296,GO:0015318,GO:0015672,GO:0015698,GO:0016020,GO:0016021,GO:0016053,GO:0019344,GO:0019752,GO:0022804,GO:0022857,GO:0022890,GO:0031224,GO:0031226,GO:0034220,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044425,GO:0044459,GO:0044464,GO:0046394,GO:0051179,GO:0051234,GO:0055085,GO:0071704,GO:0071944,GO:0072348,GO:0098655,GO:0098656,GO:0098660,GO:0098661,GO:0098662,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1901682,GO:1902358,GO:1902600 - ko:K06203 - - - - ko00000 - - iJR904.b2413,iYL1228.KPN_02760 EI24 k59_849919_1 1380355.JNIJ01000011_gene848 1.35e-59 206.0 COG1529@1|root,COG1529@2|Bacteria,1QTTJ@1224|Proteobacteria,2TQVK@28211|Alphaproteobacteria,3JRND@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria C Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain - - - - - - - - - - - - Ald_Xan_dh_C2 k59_1584191_1 1273125.Rrhod_4294 7.21e-20 95.9 COG1529@1|root,COG1529@2|Bacteria,2GIVI@201174|Actinobacteria,4FV5G@85025|Nocardiaceae 201174|Actinobacteria C Dehydrogenase - - - - - - - - - - - - Ald_Xan_dh_C,Ald_Xan_dh_C2 k59_1640946_1 702113.PP1Y_AT6612 4.46e-57 200.0 COG0823@1|root,COG1228@1|root,COG0823@2|Bacteria,COG1228@2|Bacteria,1MX3A@1224|Proteobacteria,2TUU6@28211|Alphaproteobacteria,2K0I3@204457|Sphingomonadales 204457|Sphingomonadales QU Periplasmic component of the Tol biopolymer transport system - - - - - - - - - - - - Amidohydro_1,PD40 k59_1302059_2 1236501.BAJU01000003_gene603 7.51e-39 138.0 COG0697@1|root,COG0697@2|Bacteria,1MVHN@1224|Proteobacteria,2TRCU@28211|Alphaproteobacteria,2JT6H@204441|Rhodospirillales 204441|Rhodospirillales EG EamA-like transporter family - - - - - - - - - - - - EamA k59_1697325_1 436308.Nmar_0594 7.37e-82 253.0 COG0265@1|root,arCOG02833@2157|Archaea,41S9W@651137|Thaumarchaeota 651137|Thaumarchaeota O Trypsin-like serine protease with C-terminal PDZ domain - - - - - - - - - - - - PDZ_2,Trypsin_2 k59_2441_2 1121033.AUCF01000033_gene3612 1.27e-99 305.0 COG2987@1|root,COG2987@2|Bacteria,1MU4W@1224|Proteobacteria,2TSJR@28211|Alphaproteobacteria,2JQAS@204441|Rhodospirillales 204441|Rhodospirillales E Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate hutU - 4.2.1.49 ko:K01712 ko00340,ko01100,map00340,map01100 M00045 R02914 RC00804 ko00000,ko00001,ko00002,ko01000 - - - Urocanase,Urocanase_C,Urocanase_N k59_567668_2 981369.JQMJ01000004_gene448 2.77e-34 132.0 COG4221@1|root,COG4221@2|Bacteria,2GRRV@201174|Actinobacteria,2NNF9@228398|Streptacidiphilus 201174|Actinobacteria S NAD dependent epimerase/dehydratase family - - - - - - - - - - - - adh_short k59_793596_1 926550.CLDAP_01390 9.61e-50 169.0 COG1024@1|root,COG1024@2|Bacteria,2G6G6@200795|Chloroflexi 200795|Chloroflexi I PFAM Enoyl-CoA hydratase isomerase - - 5.3.3.18 ko:K15866 ko00360,ko01120,map00360,map01120 - R09837,R09839 RC00004,RC00326,RC02689,RC03003 ko00000,ko00001,ko01000 - - - ECH_1 k59_793596_2 1382304.JNIL01000001_gene3291 3.2e-16 78.2 COG1703@1|root,COG1884@1|root,COG2185@1|root,COG1703@2|Bacteria,COG1884@2|Bacteria,COG2185@2|Bacteria,1TQAD@1239|Firmicutes,4HCMS@91061|Bacilli,27812@186823|Alicyclobacillaceae 91061|Bacilli EI Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly icmF GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005515,GO:0005525,GO:0006139,GO:0006163,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009117,GO:0009150,GO:0009259,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016866,GO:0017076,GO:0017111,GO:0019001,GO:0019637,GO:0019693,GO:0019842,GO:0031419,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0033865,GO:0033875,GO:0034032,GO:0034641,GO:0034784,GO:0035383,GO:0035639,GO:0036094,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043603,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0046906,GO:0046983,GO:0047727,GO:0048037,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:0097159,GO:0097367,GO:1901135,GO:1901265,GO:1901360,GO:1901363,GO:1901564 5.4.99.13 ko:K11942 - - - - ko00000,ko01000 - - - ArgK,B12-binding,MM_CoA_mutase k59_228376_1 95619.PM1_0225960 2.25e-33 133.0 COG1305@1|root,COG1305@2|Bacteria,1MWCE@1224|Proteobacteria,1RPH9@1236|Gammaproteobacteria 1236|Gammaproteobacteria E COG1305 Transglutaminase-like enzymes tgpA - 2.3.2.13 ko:K22452 - - - - ko00000,ko01000 - - - DUF3488,DUF4129,Transglut_core k59_2454_1 47763.JNZA01000067_gene6925 2e-05 49.3 COG1595@1|root,COG1595@2|Bacteria,2GP9D@201174|Actinobacteria 201174|Actinobacteria K Belongs to the sigma-70 factor family. ECF subfamily - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4,Sigma70_r4_2 k59_1075615_1 1283300.ATXB01000001_gene1002 3.13e-89 279.0 COG0481@1|root,COG0481@2|Bacteria,1MVZA@1224|Proteobacteria,1RPFB@1236|Gammaproteobacteria,1XE1C@135618|Methylococcales 135618|Methylococcales J Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner lepA - - ko:K03596 ko05134,map05134 - - - ko00000,ko00001 - - - EFG_C,EFG_II,GTP_EFTU,GTP_EFTU_D2,LepA_C k59_962892_1 519989.ECTPHS_06482 1.45e-35 139.0 COG4796@1|root,COG4796@2|Bacteria,1QTT6@1224|Proteobacteria,1RN3Z@1236|Gammaproteobacteria,1WWYN@135613|Chromatiales 135613|Chromatiales U type IV pilus secretin PilQ - - - ko:K02666 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - AMIN,STN,Secretin,Secretin_N k59_1132364_1 999541.bgla_1g34550 3.68e-45 158.0 COG0657@1|root,COG0657@2|Bacteria,1RD8A@1224|Proteobacteria,2VSDG@28216|Betaproteobacteria,1KGMN@119060|Burkholderiaceae 28216|Betaproteobacteria I Alpha beta hydrolase - - 3.1.1.83 ko:K14731 ko00903,ko00930,ko01220,map00903,map00930,map01220 - R03751,R06390,R06391,R06392,R06393 RC00713,RC00983,RC01505 ko00000,ko00001,ko01000 - - - Abhydrolase_3 k59_1132364_2 1123269.NX02_00435 3.26e-12 65.9 COG1051@1|root,COG1051@2|Bacteria,1QTT4@1224|Proteobacteria,2TWST@28211|Alphaproteobacteria,2K3G3@204457|Sphingomonadales 204457|Sphingomonadales F NUDIX domain - - 3.6.1.55 ko:K03574 - - - - ko00000,ko01000,ko03400 - - - NUDIX k59_2477_1 237727.NAP1_06485 6.29e-116 348.0 COG0481@1|root,COG0481@2|Bacteria,1MVZA@1224|Proteobacteria,2TR3H@28211|Alphaproteobacteria,2K17X@204457|Sphingomonadales 204457|Sphingomonadales M Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner lepA - - ko:K03596 ko05134,map05134 - - - ko00000,ko00001 - - - EFG_C,EFG_II,GTP_EFTU,GTP_EFTU_D2,LepA_C k59_793629_1 649831.L083_0358 2.96e-32 125.0 2C9AC@1|root,2Z7TR@2|Bacteria,2I07F@201174|Actinobacteria,4DFXX@85008|Micromonosporales 201174|Actinobacteria S Phage portal protein, SPP1 Gp6-like - - - - - - - - - - - - Phage_prot_Gp6 k59_793629_2 247156.NFA_15230 2.14e-18 83.2 COG4626@1|root,COG4626@2|Bacteria,2GNSB@201174|Actinobacteria,4G3SJ@85025|Nocardiaceae 201174|Actinobacteria S Terminase - - - - - - - - - - - - - k59_567676_2 436308.Nmar_0849 5.86e-98 293.0 arCOG08708@1|root,arCOG08708@2157|Archaea,41SPK@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_793639_1 1178825.ALIH01000002_gene1033 1.65e-115 333.0 COG0302@1|root,COG0302@2|Bacteria,4NFC2@976|Bacteroidetes,1HX6R@117743|Flavobacteriia 976|Bacteroidetes H GTP cyclohydrolase I folE GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003933,GO:0003934,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006066,GO:0006725,GO:0006729,GO:0006732,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009108,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019238,GO:0019438,GO:0019751,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034311,GO:0034312,GO:0034641,GO:0035639,GO:0036094,GO:0042558,GO:0042559,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046146,GO:0046165,GO:0046173,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 3.5.4.16 ko:K01495 ko00790,ko01100,map00790,map01100 M00126,M00841,M00842,M00843 R00428,R04639,R05046,R05048 RC00263,RC00294,RC00323,RC00945,RC01188 ko00000,ko00001,ko00002,ko01000 - - - GTP_cyclohydroI k59_1697357_1 379731.PST_2880 1.23e-06 51.6 COG1091@1|root,COG1091@2|Bacteria,1MUXM@1224|Proteobacteria,1RSNR@1236|Gammaproteobacteria,1Z0N8@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria M Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose rfbD - 1.1.1.133 ko:K00067 ko00521,ko00523,ko01130,map00521,map00523,map01130 M00793 R02777 RC00182 ko00000,ko00001,ko00002,ko01000 - - - RmlD_sub_bind k59_1697357_2 1270196.JCKI01000005_gene3184 7.63e-66 210.0 COG0451@1|root,COG0451@2|Bacteria,4NEZX@976|Bacteroidetes,1IPW2@117747|Sphingobacteriia 976|Bacteroidetes GM NAD dependent epimerase dehydratase family - - 4.2.1.46 ko:K01710 ko00521,ko00523,ko00525,ko01055,ko01130,map00521,map00523,map00525,map01055,map01130 M00793 R06513 RC00402 ko00000,ko00001,ko00002,ko01000 - - - GDP_Man_Dehyd k59_962932_1 1122137.AQXF01000004_gene1847 2.02e-139 417.0 COG3605@1|root,COG3605@2|Bacteria,1QTTV@1224|Proteobacteria,2TR3Z@28211|Alphaproteobacteria 28211|Alphaproteobacteria T Belongs to the PEP-utilizing enzyme family ptsP - 2.7.3.9 ko:K08484 ko02060,map02060 - - - ko00000,ko00001,ko01000,ko02000 - - - GAF,GAF_2,PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C k59_398068_1 555793.WSK_3283 5.7e-65 222.0 COG3119@1|root,COG3119@2|Bacteria,1MV92@1224|Proteobacteria,2TTXG@28211|Alphaproteobacteria 28211|Alphaproteobacteria P Arylsulfatase - - 3.1.6.1 ko:K01130 ko00140,ko00600,map00140,map00600 - R03980,R04856 RC00128,RC00231 ko00000,ko00001,ko01000 - - - Sulfatase k59_962935_1 1144305.PMI02_03421 6.21e-114 345.0 COG1574@1|root,COG1574@2|Bacteria,1R7BE@1224|Proteobacteria,2U47I@28211|Alphaproteobacteria,2K2IJ@204457|Sphingomonadales 204457|Sphingomonadales S Amidohydrolase family - - - - - - - - - - - - Amidohydro_3 k59_510917_1 1354303.M917_2382 3.78e-57 184.0 COG0590@1|root,COG0590@2|Bacteria,1RGU0@1224|Proteobacteria,1S60Z@1236|Gammaproteobacteria,3NN6N@468|Moraxellaceae 1236|Gammaproteobacteria FJ Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2) tadA GO:0002097,GO:0002100,GO:0003674,GO:0003824,GO:0004000,GO:0005488,GO:0006139,GO:0006382,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008251,GO:0008270,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016553,GO:0016787,GO:0016810,GO:0016814,GO:0019239,GO:0034470,GO:0034641,GO:0034660,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0046872,GO:0046914,GO:0052717,GO:0071704,GO:0090304,GO:1901360 3.5.4.33 ko:K11991 - - R10223 RC00477 ko00000,ko01000,ko03016 - - - MafB19-deam,dCMP_cyt_deam_1 k59_510917_2 1121447.JONL01000001_gene1076 5e-15 77.4 COG0834@1|root,COG2199@1|root,COG0834@2|Bacteria,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria,42MCD@68525|delta/epsilon subdivisions,2X5DF@28221|Deltaproteobacteria,2MG1M@213115|Desulfovibrionales 28221|Deltaproteobacteria ET Bacterial periplasmic substrate-binding proteins - - - - - - - - - - - - GGDEF,NMT1,SBP_bac_3 k59_1414845_1 1123242.JH636434_gene3175 5.4e-96 304.0 COG0188@1|root,COG0188@2|Bacteria,2IY0U@203682|Planctomycetes 203682|Planctomycetes L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrA - 5.99.1.3 ko:K02469 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseA_C,DNA_topoisoIV k59_1302113_1 1385935.N836_15945 8.27e-48 162.0 2DMFF@1|root,32R5F@2|Bacteria,1GAQC@1117|Cyanobacteria,1HGKT@1150|Oscillatoriales 1117|Cyanobacteria S IMG reference gene - - - - - - - - - - - - - k59_567707_1 1278307.KB907040_gene1962 6.71e-30 109.0 COG1550@1|root,COG1550@2|Bacteria,1NGDU@1224|Proteobacteria 1224|Proteobacteria S Protein of unknown function (DUF503) - - - ko:K09764 - - - - ko00000 - - - DUF503 k59_1188907_1 1123270.ATUR01000009_gene2026 2.89e-57 191.0 COG2855@1|root,COG2855@2|Bacteria,1MVIP@1224|Proteobacteria,2TVK9@28211|Alphaproteobacteria,2K1K1@204457|Sphingomonadales 204457|Sphingomonadales S Conserved hypothetical protein 698 - - - - - - - - - - - - Cons_hypoth698 k59_2506_1 207954.MED92_09606 5.23e-45 162.0 COG2304@1|root,COG2304@2|Bacteria,1MW8K@1224|Proteobacteria,1RNU3@1236|Gammaproteobacteria,1XI15@135619|Oceanospirillales 135619|Oceanospirillales S protein containing a von Willebrand factor type A (vWA) domain - - - ko:K07114 - - - - ko00000,ko02000 1.A.13.2.2,1.A.13.2.3 - - VIT,VWA_3 k59_1753832_1 326424.FRAAL1549 6.54e-17 83.2 COG1028@1|root,COG2070@1|root,COG3321@1|root,COG1028@2|Bacteria,COG2070@2|Bacteria,COG3321@2|Bacteria,2H477@201174|Actinobacteria,4EU82@85013|Frankiales 201174|Actinobacteria Q Beta-ketoacyl synthase - - - - - - - - - - - - Acyl_transf_1,KAsynt_C_assoc,KR,Ketoacyl-synt_C,NMO,PP-binding,PS-DH,ketoacyl-synt k59_1358529_1 519989.ECTPHS_02169 6.53e-116 341.0 COG2255@1|root,COG2255@2|Bacteria,1MU38@1224|Proteobacteria,1RNWY@1236|Gammaproteobacteria,1WWB3@135613|Chromatiales 135613|Chromatiales L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing ruvB - 3.6.4.12 ko:K03551 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - RuvB_C,RuvB_N k59_680416_1 748247.AZKH_p0309 1.62e-06 55.5 COG0642@1|root,COG0784@1|root,COG4192@1|root,COG0784@2|Bacteria,COG2205@2|Bacteria,COG4192@2|Bacteria,1NRP8@1224|Proteobacteria,2VGZQ@28216|Betaproteobacteria 28216|Betaproteobacteria T Histidine kinase - - - - - - - - - - - - CHASE,HATPase_c,HisKA,Hpt,PAS_3,PAS_4,PAS_9,Response_reg k59_737382_1 644282.Deba_1967 2.2e-77 243.0 COG0126@1|root,COG0126@2|Bacteria,1MUNU@1224|Proteobacteria,42N4P@68525|delta/epsilon subdivisions,2WJ0B@28221|Deltaproteobacteria 28221|Deltaproteobacteria F Belongs to the phosphoglycerate kinase family pgk - 2.7.2.3 ko:K00927 ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01512 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000,ko04147 - - - PGK k59_1302123_1 1005048.CFU_1429 4.81e-21 96.7 COG3131@1|root,COG3131@2|Bacteria,1MUNX@1224|Proteobacteria,2VJBC@28216|Betaproteobacteria,473ZQ@75682|Oxalobacteraceae 28216|Betaproteobacteria P Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) mdoG - - ko:K03670 - - - - ko00000 - - - MdoG k59_1302123_2 1085623.GNIT_3493 3.88e-96 303.0 COG2943@1|root,COG2943@2|Bacteria,1MVXZ@1224|Proteobacteria,1RMGX@1236|Gammaproteobacteria,465E9@72275|Alteromonadaceae 1236|Gammaproteobacteria M COG2943 Membrane glycosyltransferase mdoH GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0005975,GO:0005976,GO:0006073,GO:0006950,GO:0006970,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009250,GO:0009628,GO:0009987,GO:0016020,GO:0016021,GO:0016051,GO:0016740,GO:0016757,GO:0031224,GO:0031226,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051273,GO:0051274,GO:0071704,GO:0071944,GO:1901576 - ko:K03669 - - - - ko00000,ko01000,ko01003,ko02000 4.D.3.1.1 GT2 - Glyco_trans_2_3,Glycos_transf_2 k59_1245632_1 1121374.KB891576_gene248 2.72e-12 68.9 COG2304@1|root,COG2304@2|Bacteria,1MW8K@1224|Proteobacteria,1RNU3@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Von willebrand factor, type a - - - ko:K07114 - - - - ko00000,ko02000 1.A.13.2.2,1.A.13.2.3 - - VIT,VWA_3 k59_1245632_2 203122.Sde_1016 5.16e-17 79.3 COG0745@1|root,COG0745@2|Bacteria,1MVCB@1224|Proteobacteria,1RM87@1236|Gammaproteobacteria,465DT@72275|Alteromonadaceae 1236|Gammaproteobacteria T COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain chvI GO:0000976,GO:0000984,GO:0000986,GO:0000987,GO:0001017,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0005488,GO:0005515,GO:0006355,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0042802,GO:0043565,GO:0044212,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2001141 - ko:K02483,ko:K07663 ko02020,map02020 M00449 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Trans_reg_C k59_850059_1 1288484.APCS01000005_gene1182 6.27e-21 96.7 COG0060@1|root,COG0060@2|Bacteria,1WI61@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) ileS GO:0003674,GO:0003824,GO:0004812,GO:0004822,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006428,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.5 ko:K01870 ko00970,map00970 M00359,M00360 R03656 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,tRNA-synt_1 k59_462641_2 234267.Acid_2554 1.25e-109 331.0 COG3344@1|root,COG3344@2|Bacteria 2|Bacteria L reverse transcriptase - - 2.7.7.49 ko:K00986 - - - - ko00000,ko01000 - - - GIIM,RVT_1 k59_1422688_1 1239962.C943_00085 5.24e-96 297.0 COG4656@1|root,COG4656@2|Bacteria,4NIS7@976|Bacteroidetes 976|Bacteroidetes C Part of a membrane complex involved in electron transport rnfC - - ko:K03615 - - - - ko00000 - - - Complex1_51K,Fer4_10,Fer4_17,Fer4_7,RnfC_N,SLBB k59_1649024_1 439496.RBY4I_308 1.07e-10 62.8 COG0730@1|root,COG0730@2|Bacteria,1MVY3@1224|Proteobacteria,2TU6M@28211|Alphaproteobacteria 28211|Alphaproteobacteria S membrane transporter protein - - - ko:K07090 - - - - ko00000 - - - TauE k59_1649024_2 404589.Anae109_2149 1.61e-80 252.0 COG0583@1|root,COG0583@2|Bacteria,1MVA1@1224|Proteobacteria,42VVS@68525|delta/epsilon subdivisions,2X5WR@28221|Deltaproteobacteria,2YVAQ@29|Myxococcales 28221|Deltaproteobacteria K Bacterial regulatory helix-turn-helix protein, lysR family - - - ko:K04761 ko02026,map02026 - - - ko00000,ko00001,ko03000 - - - HTH_1,LysR_substrate k59_576312_2 90371.CY43_04705 6.11e-40 139.0 COG1176@1|root,COG1176@2|Bacteria,1MVGM@1224|Proteobacteria,1RNNZ@1236|Gammaproteobacteria,3ZKIV@590|Salmonella 1236|Gammaproteobacteria P Binding-protein-dependent transport system inner membrane component potH GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0015695,GO:0015696,GO:0015846,GO:0015847,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0032991,GO:0043190,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944,GO:0098533,GO:0098796,GO:0098797,GO:1902494,GO:1902495,GO:1904949,GO:1990351 - ko:K11075 ko02010,map02010 M00300 - - ko00000,ko00001,ko00002,ko02000 3.A.1.11.2 - iAF1260.b0856,iBWG_1329.BWG_0709,iE2348C_1286.E2348C_0853,iECDH10B_1368.ECDH10B_0926,iECDH1ME8569_1439.ECDH1ME8569_0808,iEcDH1_1363.EcDH1_2786,iJO1366.b0856,iJR904.b0856,iY75_1357.Y75_RS04455 BPD_transp_1 k59_68642_1 1395571.TMS3_0103545 1.6e-18 86.7 COG1253@1|root,COG1253@2|Bacteria,1MV3P@1224|Proteobacteria,1RZYP@1236|Gammaproteobacteria 1236|Gammaproteobacteria P Hemolysins and related proteins containing CBS domains tlyC_1 - - - - - - - - - - - CBS,CorC_HlyC,DUF21 k59_1367721_1 436308.Nmar_1109 6.81e-137 394.0 COG2141@1|root,arCOG02410@2157|Archaea,41SBM@651137|Thaumarchaeota 651137|Thaumarchaeota C Luciferase-like monooxygenase - - - ko:K14728 - - - - ko00000,ko01000 - - - Bac_luciferase k59_406954_1 1229909.NSED_02420 1.75e-96 289.0 COG0306@1|root,arCOG02267@2157|Archaea,41SD8@651137|Thaumarchaeota 651137|Thaumarchaeota P Phosphate transporter family - - - ko:K03306 - - - - ko00000 2.A.20 - - PHO4 k59_1141158_1 926569.ANT_29800 7.72e-67 216.0 COG0621@1|root,COG0621@2|Bacteria,2G5QK@200795|Chloroflexi 200795|Chloroflexi J Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine miaB - 2.8.4.3 ko:K06168 - - R10645,R10646,R10647 RC00003,RC00980,RC03221,RC03222 ko00000,ko01000,ko03016 - - - Radical_SAM,TRAM,UPF0004 k59_406955_1 46234.ANA_C10776 2.28e-31 127.0 COG2931@1|root,COG3211@1|root,COG2931@2|Bacteria,COG3211@2|Bacteria 2|Bacteria O Phosphatase - - 3.1.3.8,3.1.4.46 ko:K01083,ko:K01126,ko:K07093 ko00562,ko00564,map00562,map00564 - R01030,R01470,R03371 RC00017,RC00078,RC00425 ko00000,ko00001,ko01000 - - - Cadherin,DUF4114,DUF839,Exo_endo_phos,GDPD,HemolysinCabind,PA14,Phytase,Phytase-like k59_1649875_1 1229909.NSED_00615 1.18e-104 319.0 COG1001@1|root,arCOG00693@2157|Archaea,41SZH@651137|Thaumarchaeota 651137|Thaumarchaeota F Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family ade - 3.5.4.2 ko:K01486 ko00230,ko01100,map00230,map01100 - R01244 RC00477 ko00000,ko00001,ko01000 - - - Adenine_deam_C,Amidohydro_1 k59_350942_1 748247.AZKH_2167 1.88e-52 174.0 COG2816@1|root,COG2816@2|Bacteria,1QGCX@1224|Proteobacteria,2VQIR@28216|Betaproteobacteria,2KW28@206389|Rhodocyclales 206389|Rhodocyclales L NADH pyrophosphatase-like rudimentary NUDIX domain - - 3.6.1.22 ko:K03426 ko00760,ko01100,ko04146,map00760,map01100,map04146 - R00103,R03004,R11104 RC00002 ko00000,ko00001,ko01000 - - - NUDIX,NUDIX-like,zf-NADH-PPase k59_1762711_1 153948.NAL212_2947 1.51e-20 87.4 COG2885@1|root,COG2885@2|Bacteria,1MYBP@1224|Proteobacteria,2VR0Y@28216|Betaproteobacteria,372ED@32003|Nitrosomonadales 28216|Betaproteobacteria M Belongs to the ompA family yiaD_1 - - ko:K03286 - - - - ko00000,ko02000 1.B.6 - - Gly-zipper_Omp,Gly-zipper_YMGG,OmpA k59_971259_3 436308.Nmar_1704 6.57e-44 145.0 arCOG08775@1|root,arCOG08775@2157|Archaea,41T9K@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1537002_1 1088721.NSU_3458 4.04e-31 115.0 COG5517@1|root,COG5517@2|Bacteria,1MZ9K@1224|Proteobacteria 1224|Proteobacteria Q Ring hydroxylating beta subunit bphE - 1.14.12.12,1.14.12.23,1.14.12.24 ko:K14580 ko00624,ko00626,ko00627,ko00633,ko00642,ko01100,ko01120,ko01220,map00624,map00626,map00627,map00633,map00642,map01100,map01120,map01220 M00534 R02968,R05422,R05423,R05424,R05425,R05426,R05427,R06909,R06930,R06937,R07704,R07706,R09159,R09233 RC00091,RC00098,RC00157,RC00274,RC00275,RC01376,RC01377,RC01801 br01602,ko00000,ko00001,ko00002,ko01000 - - - Ring_hydroxyl_B k59_1537002_2 497321.C664_02380 0.000165 44.7 COG1802@1|root,COG1802@2|Bacteria,1Q85H@1224|Proteobacteria,2VIB4@28216|Betaproteobacteria,2KV86@206389|Rhodocyclales 206389|Rhodocyclales K transcriptional - - - - - - - - - - - - FCD,GntR k59_463370_1 1123279.ATUS01000006_gene3464 3.36e-22 98.2 COG0837@1|root,COG0837@2|Bacteria,1MVFI@1224|Proteobacteria,1RNUY@1236|Gammaproteobacteria,1J62Y@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Belongs to the bacterial glucokinase family glk - 2.7.1.2 ko:K00845 ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200 M00001,M00549 R00299,R01600,R01786 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - Glucokinase k59_1197874_1 1056820.KB900700_gene1132 2.63e-93 293.0 COG0445@1|root,COG0445@2|Bacteria,1MU6F@1224|Proteobacteria,1RMM1@1236|Gammaproteobacteria,2PN4D@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria D GidA associated domain 3 gidA GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009314,GO:0009411,GO:0009416,GO:0009451,GO:0009628,GO:0009987,GO:0010467,GO:0016070,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0050896,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901363 - ko:K03495 - - R08701 RC00053,RC00209,RC00870 ko00000,ko03016,ko03036 - - - GIDA,GIDA_assoc k59_463372_1 1442599.JAAN01000030_gene2086 3.15e-39 147.0 COG3866@1|root,COG3866@2|Bacteria,1QPFF@1224|Proteobacteria,1RY07@1236|Gammaproteobacteria,1XBF9@135614|Xanthomonadales 135614|Xanthomonadales G Pectate lyase pelB - 4.2.2.2 ko:K01728 ko00040,ko02024,map00040,map02024 - R02361,R06240 RC00049,RC00705 ko00000,ko00001,ko01000 - - - Pec_lyase_C k59_1197877_1 452863.Achl_2644 3.33e-06 51.6 COG4961@1|root,COG4961@2|Bacteria,2IS3K@201174|Actinobacteria 201174|Actinobacteria U TadE-like protein - - - - - - - - - - - - TadE k59_1537023_1 43151.ADAC008472-PA 9.18e-06 49.7 COG0667@1|root,KOG1576@2759|Eukaryota,39S2A@33154|Opisthokonta,3BIKY@33208|Metazoa,3D446@33213|Bilateria,41V2W@6656|Arthropoda,3SHUJ@50557|Insecta,44XSH@7147|Diptera,45FV4@7148|Nematocera 33208|Metazoa C Aldo/keto reductase family - GO:0003008,GO:0007600,GO:0007610,GO:0007638,GO:0008150,GO:0009581,GO:0009582,GO:0009605,GO:0009612,GO:0009628,GO:0031644,GO:0031646,GO:0032101,GO:0032103,GO:0032501,GO:0044057,GO:0048518,GO:0048520,GO:0048583,GO:0048584,GO:0050789,GO:0050795,GO:0050877,GO:0050896,GO:0050906,GO:0050954,GO:0050974,GO:0050975,GO:0050976,GO:0050982,GO:0051239,GO:0051240,GO:0051606,GO:0051931,GO:0065007,GO:1905787,GO:1905789,GO:1905790,GO:1905792 - - - - - - - - - - Aldo_ket_red k59_1311175_1 1123392.AQWL01000009_gene1115 4.37e-76 239.0 COG2046@1|root,COG2046@2|Bacteria,1MUQB@1224|Proteobacteria,2VR2T@28216|Betaproteobacteria 28216|Betaproteobacteria H PUA-like domain sat - 2.7.7.4 ko:K00958 ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130 M00176,M00596 R00529,R04929 RC02809,RC02889 ko00000,ko00001,ko00002,ko01000 - - - ATP-sulfurylase,PK,PUA_2 k59_576349_2 1384054.N790_11830 1.7e-52 176.0 COG3279@1|root,COG3279@2|Bacteria,1MUE8@1224|Proteobacteria,1RMJJ@1236|Gammaproteobacteria,1X5A5@135614|Xanthomonadales 135614|Xanthomonadales KT LytTr DNA-binding domain - - - ko:K02477 - - - - ko00000,ko02022 - - - LytTR,Response_reg k59_1084698_1 933262.AXAM01000021_gene459 2.41e-28 120.0 COG2114@1|root,COG4252@1|root,COG2114@2|Bacteria,COG4252@2|Bacteria,1MV1V@1224|Proteobacteria,42N5S@68525|delta/epsilon subdivisions,2WIUS@28221|Deltaproteobacteria,2MJZH@213118|Desulfobacterales 28221|Deltaproteobacteria T CHASE2 - - 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 - - - CHASE2,Guanylate_cyc k59_689337_1 1056820.KB900641_gene654 2.62e-87 272.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,2PN64@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria T Sigma-54 interaction domain cbrB - - - - - - - - - - - Response_reg,Sigma54_activat k59_463381_1 1279015.KB908457_gene2243 2.71e-11 68.9 COG0477@1|root,COG2814@2|Bacteria,1MVUF@1224|Proteobacteria,1RP39@1236|Gammaproteobacteria,1Y5QI@135624|Aeromonadales 135624|Aeromonadales EGP Transmembrane secretion effector - - - - - - - - - - - - MFS_1 k59_1593261_1 187272.Mlg_0941 3.08e-89 279.0 COG1217@1|root,COG1217@2|Bacteria,1MV5Q@1224|Proteobacteria,1RMJB@1236|Gammaproteobacteria,1WW7K@135613|Chromatiales 135613|Chromatiales T GTP-binding protein TypA - - - ko:K06207 - - - - ko00000 - - - EFG_C,GTP_EFTU,GTP_EFTU_D2 k59_181068_1 1500257.JQNM01000001_gene3868 1.76e-37 140.0 COG0621@1|root,COG0621@2|Bacteria,1MURS@1224|Proteobacteria,2TQN6@28211|Alphaproteobacteria,4BANY@82115|Rhizobiaceae 28211|Alphaproteobacteria J Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine miaB - 2.8.4.3 ko:K06168 - - R10645,R10646,R10647 RC00003,RC00980,RC03221,RC03222 ko00000,ko01000,ko03016 - - - Radical_SAM,TRAM,UPF0004 k59_11842_11 298654.FraEuI1c_3362 4.24e-33 126.0 2DUN5@1|root,33RC4@2|Bacteria,2IF1C@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - PG_binding_1 k59_11842_17 1340713.S5Y2Y9_9CAUD 6.39e-09 58.9 4QDM7@10239|Viruses,4R03F@35237|dsDNA viruses no RNA stage,4QPZC@28883|Caudovirales 28883|Caudovirales - - - - - - - - - - - - - - - k59_11842_21 68219.JNXI01000031_gene5502 1.95e-50 196.0 COG0749@1|root,COG0749@2|Bacteria,2IG0A@201174|Actinobacteria 201174|Actinobacteria L DNA polymerase - - 2.7.7.7 ko:K02334 - - - - ko00000,ko01000 - - - DNA_pol_A k59_576385_1 314278.NB231_16878 1.15e-65 211.0 COG1086@1|root,COG1086@2|Bacteria,1MWKY@1224|Proteobacteria,1RNQ2@1236|Gammaproteobacteria,1WXX0@135613|Chromatiales 135613|Chromatiales M Polysaccharide biosynthesis protein - - - - - - - - - - - - Polysacc_syn_2C,Polysacc_synt_2 k59_1537068_1 330214.NIDE2054 1.37e-133 387.0 COG1186@1|root,COG1186@2|Bacteria,3J0EX@40117|Nitrospirae 40117|Nitrospirae J Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA prfB - - ko:K02836 - - - - ko00000,ko03012 - - - PCRF,RF-1 k59_1762761_1 1442599.JAAN01000010_gene308 1.74e-19 92.4 COG4232@1|root,COG4232@2|Bacteria,1MU8W@1224|Proteobacteria,1RPF7@1236|Gammaproteobacteria,1X43V@135614|Xanthomonadales 135614|Xanthomonadales CO Thiol disulfide Interchange Protein dsbD - 1.8.1.8 ko:K04084 - - - - ko00000,ko01000,ko03110 5.A.1.1 - - DsbC,DsbD,Thioredoxin_7 k59_745801_1 1131269.AQVV01000025_gene2328 2.05e-26 110.0 COG0095@1|root,COG0095@2|Bacteria 2|Bacteria H Lipoate-protein ligase lipM GO:0003674,GO:0003824,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009106,GO:0009107,GO:0009108,GO:0009249,GO:0009987,GO:0010467,GO:0016053,GO:0016415,GO:0016740,GO:0016746,GO:0016747,GO:0018065,GO:0018130,GO:0018193,GO:0018205,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0051604,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901576 6.3.1.20 ko:K03800 ko00785,ko01100,map00785,map01100 - R07770,R07771,R11143 RC00043,RC00070,RC00090,RC00992,RC02896 ko00000,ko00001,ko01000 - - - BPL_LplA_LipB k59_1649960_1 593907.Celgi_2447 1.18e-19 87.8 COG2723@1|root,COG2723@2|Bacteria,2GJAF@201174|Actinobacteria,4F1UA@85016|Cellulomonadaceae 201174|Actinobacteria G PFAM glycoside hydrolase family 1 bglA - 3.2.1.21 ko:K05350 ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110 - R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040 RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248 ko00000,ko00001,ko01000 - - - Glyco_hydro_1 k59_1649960_2 67356.KL575631_gene7306 4.78e-49 160.0 COG2185@1|root,COG2185@2|Bacteria,2IK19@201174|Actinobacteria 201174|Actinobacteria I B12 binding domain - - - - - - - - - - - - B12-binding k59_859710_1 316407.85675309 1.87e-153 429.0 COG3005@1|root,COG3005@2|Bacteria,1MWV2@1224|Proteobacteria,1RQ9A@1236|Gammaproteobacteria,3XNSB@561|Escherichia 1236|Gammaproteobacteria C Mediates electron flow from quinones to the NapAB complex napC GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0022900,GO:0031224,GO:0044237,GO:0044425,GO:0044464,GO:0045333,GO:0055114,GO:0071944 - ko:K02569 - - - - ko00000 - - iEcolC_1368.EcolC_1448 Cytochrom_NNT k59_859710_2 199310.c2741 3.76e-24 94.0 COG3043@1|root,COG3043@2|Bacteria,1RHGD@1224|Proteobacteria,1S84V@1236|Gammaproteobacteria,3XPIR@561|Escherichia 1236|Gammaproteobacteria C Electron transfer subunit of the periplasmic nitrate reductase complex NapAB napB GO:0006091,GO:0008150,GO:0008152,GO:0009061,GO:0009987,GO:0015980,GO:0044237,GO:0045333,GO:0055114 - ko:K02568 ko00910,ko01120,map00910,map01120 M00529,M00530 R00798 RC02812 ko00000,ko00001,ko00002 - - iAF1260.b2203,iBWG_1329.BWG_1976,iE2348C_1286.E2348C_2347,iECDH10B_1368.ECDH10B_2360,iECDH1ME8569_1439.ECDH1ME8569_2138,iECED1_1282.ECED1_2668,iECH74115_1262.ECH74115_3340,iECIAI39_1322.ECIAI39_2341,iECNA114_1301.ECNA114_2295,iECOK1_1307.ECOK1_2437,iECP_1309.ECP_2244,iECS88_1305.ECS88_2350,iECSF_1327.ECSF_2084,iECSP_1301.ECSP_3082,iECUMN_1333.ECUMN_2538,iETEC_1333.ETEC_2337,iEcDH1_1363.EcDH1_1456,iEcolC_1368.EcolC_1447,iG2583_1286.G2583_2744,iJO1366.b2203,iLF82_1304.LF82_1453,iNRG857_1313.NRG857_11180,iSFV_1184.SFV_2279,iSF_1195.SF2287,iSFxv_1172.SFxv_2521,iS_1188.S2417,iUMN146_1321.UM146_05790,iY75_1357.Y75_RS11525 NapB k59_463421_1 1127673.GLIP_2499 8.34e-05 48.1 COG3086@1|root,COG3086@2|Bacteria,1N6QS@1224|Proteobacteria,1SCTM@1236|Gammaproteobacteria,4685E@72275|Alteromonadaceae 1236|Gammaproteobacteria T COG3086 Positive regulator of sigma E activity rseC GO:0005575,GO:0005623,GO:0005886,GO:0006950,GO:0006979,GO:0008150,GO:0016020,GO:0044464,GO:0050896,GO:0071944 - ko:K03803 - - - - ko00000,ko03021 - - - RseC_MucC k59_11869_1 1229909.NSED_01430 1.8e-89 278.0 COG0260@1|root,arCOG04322@2157|Archaea,41SYD@651137|Thaumarchaeota 651137|Thaumarchaeota E Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides pepA - 3.4.11.1 ko:K01255 ko00480,ko01100,map00480,map01100 - R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 - - - Peptidase_M17,Peptidase_M17_N k59_294594_2 215803.DB30_4136 8.56e-40 150.0 COG0187@1|root,COG0187@2|Bacteria,1MVKT@1224|Proteobacteria,42M7M@68525|delta/epsilon subdivisions,2WJ9X@28221|Deltaproteobacteria,2YU54@29|Myxococcales 28221|Deltaproteobacteria L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrB - 5.99.1.3 ko:K02470 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim k59_68756_1 1192759.AKIB01000065_gene3394 1.88e-67 218.0 COG0477@1|root,COG2814@2|Bacteria,1MW19@1224|Proteobacteria,2TRJ1@28211|Alphaproteobacteria,2K0JH@204457|Sphingomonadales 204457|Sphingomonadales EGP Major facilitator superfamily - - - ko:K07552 - - - - ko00000,ko02000 2.A.1.2 - - MFS_1 k59_181106_1 390989.JOEG01000017_gene6167 8.08e-28 110.0 COG2197@1|root,COG2197@2|Bacteria,2ICVI@201174|Actinobacteria 201174|Actinobacteria T helix_turn_helix, Lux Regulon - - - - - - - - - - - - GerE,Response_reg k59_1537105_1 1007103.AFHW01000020_gene78 1.32e-13 77.0 COG0840@1|root,COG0840@2|Bacteria,1TP5A@1239|Firmicutes,4H9RZ@91061|Bacilli,26QU5@186822|Paenibacillaceae 91061|Bacilli NT chemotaxis protein cheW9 - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - HAMP,MCPsignal,dCache_1 k59_1423563_1 1122137.AQXF01000001_gene3229 7.51e-13 70.9 COG3107@1|root,COG3107@2|Bacteria,1MUHR@1224|Proteobacteria,2TW21@28211|Alphaproteobacteria 28211|Alphaproteobacteria M COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component - - - - - - - - - - - - Peripla_BP_6 k59_1423563_2 5762.XP_002681610.1 0.000232 43.5 COG0313@1|root,2QQ7V@2759|Eukaryota 2759|Eukaryota H Tetrapyrrole (Corrin/Porphyrin) Methylases - - 2.1.1.198 ko:K07056 - - - - ko00000,ko01000,ko03009 - - - TP_methylase k59_859724_1 1266914.ATUK01000012_gene301 3.17e-56 189.0 COG0772@1|root,COG0772@2|Bacteria,1MUK3@1224|Proteobacteria,1RMEJ@1236|Gammaproteobacteria,1WWAV@135613|Chromatiales 135613|Chromatiales M Peptidoglycan polymerase that is essential for cell wall elongation mrdB - - ko:K05837 - - - - ko00000,ko03036 - - - FTSW_RODA_SPOVE k59_753974_1 6669.EFX79557 4.56e-09 58.5 COG1960@1|root,KOG0139@2759|Eukaryota,38H6J@33154|Opisthokonta,3BC6X@33208|Metazoa,3CVK7@33213|Bilateria,41VCW@6656|Arthropoda 33208|Metazoa E flavin adenine dinucleotide binding. It is involved in the biological process described with oxidation-reduction process ACADS GO:0000062,GO:0000166,GO:0003674,GO:0003824,GO:0003995,GO:0004085,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005740,GO:0005759,GO:0006082,GO:0006139,GO:0006351,GO:0006352,GO:0006366,GO:0006367,GO:0006629,GO:0006631,GO:0006635,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009059,GO:0009062,GO:0009605,GO:0009719,GO:0009725,GO:0009987,GO:0009991,GO:0010033,GO:0010467,GO:0014070,GO:0016020,GO:0016042,GO:0016043,GO:0016054,GO:0016070,GO:0016491,GO:0016592,GO:0016627,GO:0017076,GO:0018130,GO:0019395,GO:0019438,GO:0019605,GO:0019626,GO:0019752,GO:0022607,GO:0030258,GO:0030554,GO:0031090,GO:0031667,GO:0031960,GO:0031966,GO:0031967,GO:0031974,GO:0031975,GO:0031981,GO:0032553,GO:0032555,GO:0032559,GO:0032774,GO:0032787,GO:0032991,GO:0033218,GO:0033539,GO:0033993,GO:0034440,GO:0034641,GO:0034645,GO:0034654,GO:0036094,GO:0042221,GO:0042594,GO:0043167,GO:0043168,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044249,GO:0044255,GO:0044260,GO:0044271,GO:0044281,GO:0044282,GO:0044422,GO:0044424,GO:0044428,GO:0044429,GO:0044444,GO:0044446,GO:0044451,GO:0044464,GO:0046359,GO:0046395,GO:0046459,GO:0046483,GO:0048037,GO:0048545,GO:0050660,GO:0050662,GO:0050896,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0051384,GO:0052890,GO:0055114,GO:0065003,GO:0070013,GO:0071704,GO:0071840,GO:0072329,GO:0090304,GO:0097159,GO:0097367,GO:0097659,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901567,GO:1901575,GO:1901576,GO:1901681 1.3.8.1 ko:K00248 ko00071,ko00280,ko00650,ko01100,ko01110,ko01120,ko01200,ko01212,map00071,map00280,map00650,map01100,map01110,map01120,map01200,map01212 - R01175,R01178,R02661,R03172,R04751 RC00052,RC00068,RC00076,RC00120,RC00148 ko00000,ko00001,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_753974_2 1005048.CFU_0805 1.71e-05 48.1 COG0639@1|root,COG0639@2|Bacteria,1MV10@1224|Proteobacteria,2VHV6@28216|Betaproteobacteria,472UW@75682|Oxalobacteraceae 28216|Betaproteobacteria T Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP apaH - 3.6.1.41 ko:K01525 ko00230,map00230 - R00125 RC00002 ko00000,ko00001,ko01000 - - - Metallophos k59_923690_1 1278073.MYSTI_07874 4.33e-74 254.0 COG3391@1|root,COG3391@2|Bacteria,1R66T@1224|Proteobacteria,439FZ@68525|delta/epsilon subdivisions,2X4RS@28221|Deltaproteobacteria,2YZGC@29|Myxococcales 28221|Deltaproteobacteria G 6-phosphogluconolactonase activity - - - - - - - - - - - - - k59_697705_2 1229909.NSED_03290 3.97e-107 314.0 COG1651@1|root,arCOG02868@2157|Archaea,41T1M@651137|Thaumarchaeota 651137|Thaumarchaeota O DSBA oxidoreductase - - - - - - - - - - - - Thioredoxin_4 k59_414958_1 2074.JNYD01000002_gene5781 3.75e-67 222.0 COG2759@1|root,COG2759@2|Bacteria,2GT0X@201174|Actinobacteria,4DXJB@85010|Pseudonocardiales 201174|Actinobacteria F Belongs to the formate--tetrahydrofolate ligase family fhs - 6.3.4.3 ko:K01938 ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200 M00140,M00377 R00943 RC00026,RC00111 ko00000,ko00001,ko00002,ko01000 - - - FTHFS k59_414958_2 700508.D174_19245 6.59e-15 75.1 COG0746@1|root,COG0746@2|Bacteria,2IACX@201174|Actinobacteria,234SA@1762|Mycobacteriaceae 201174|Actinobacteria H Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor mobA GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 2.7.7.77 ko:K03752 ko00790,ko01100,map00790,map01100 - R11581 - ko00000,ko00001,ko01000 - - - NTP_transf_3 k59_1206272_1 1286106.MPL1_06959 2.01e-06 49.7 COG0495@1|root,COG0495@2|Bacteria,1MV47@1224|Proteobacteria,1RP14@1236|Gammaproteobacteria,4609P@72273|Thiotrichales 72273|Thiotrichales J Belongs to the class-I aminoacyl-tRNA synthetase family leuS - 6.1.1.4 ko:K01869 ko00970,map00970 M00359,M00360 R03657 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - Anticodon_1,tRNA-synt_1,tRNA-synt_1_2 k59_1206272_2 519989.ECTPHS_03031 1.41e-20 90.1 COG2980@1|root,COG2980@2|Bacteria,1NGPX@1224|Proteobacteria,1SGKQ@1236|Gammaproteobacteria,1WY80@135613|Chromatiales 135613|Chromatiales M Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane lptE - - ko:K03643 - - - - ko00000,ko02000 1.B.42.1 - - LptE k59_923699_1 1129794.C427_5517 4.52e-63 214.0 COG2272@1|root,COG2272@2|Bacteria,1MVQZ@1224|Proteobacteria,1RPFW@1236|Gammaproteobacteria,465DX@72275|Alteromonadaceae 1236|Gammaproteobacteria I Carboxylesterase family - - - ko:K03929 - - - - ko00000,ko01000 - CE10 - COesterase k59_20035_1 570967.JMLV01000014_gene2058 7.35e-32 119.0 COG1678@1|root,COG1678@2|Bacteria,1RCXM@1224|Proteobacteria,2TTX4@28211|Alphaproteobacteria,2JSB3@204441|Rhodospirillales 204441|Rhodospirillales K Belongs to the UPF0301 (AlgH) family - - - ko:K07735 - - - - ko00000,ko03000 - - - DUF179 k59_302990_1 377629.TERTU_1384 8.92e-68 226.0 COG0128@1|root,COG0287@1|root,COG0128@2|Bacteria,COG0287@2|Bacteria,1MWMK@1224|Proteobacteria,1RQ8U@1236|Gammaproteobacteria,2PMVM@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria E EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase) aroA - 1.3.1.12,1.3.1.43,2.5.1.19 ko:K00210,ko:K00220,ko:K00800 ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230 M00022,M00025,M00040 R00732,R01728,R03460 RC00125,RC00350 ko00000,ko00001,ko00002,ko01000 - - - EPSP_synthase,PDH k59_1714519_1 94624.Bpet2800 3.35e-109 326.0 COG0624@1|root,COG0624@2|Bacteria,1MW6G@1224|Proteobacteria,2VHRF@28216|Betaproteobacteria,3T1MH@506|Alcaligenaceae 28216|Betaproteobacteria E Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls dapE - 3.5.1.18 ko:K01439 ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230 M00016 R02734 RC00064,RC00090 ko00000,ko00001,ko00002,ko01000 - - - M20_dimer,Peptidase_M20 k59_1771006_1 94624.Bpet2015 1.07e-06 50.4 COG0525@1|root,COG0525@2|Bacteria,1MV7B@1224|Proteobacteria,2VH5Z@28216|Betaproteobacteria,3T1CD@506|Alcaligenaceae 28216|Betaproteobacteria J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner valS - 6.1.1.9 ko:K01873 ko00970,map00970 M00359,M00360 R03665 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1 k59_1771006_2 1140.Synpcc7942_1879 4.54e-34 126.0 COG0714@1|root,COG0714@2|Bacteria,1G1CG@1117|Cyanobacteria,1GZ7G@1129|Synechococcus 1117|Cyanobacteria S ATPase family associated with various cellular activities (AAA) moxR - - ko:K03924 - - - - ko00000,ko01000 - - - AAA_3 k59_1262244_1 243231.GSU2187 6.28e-37 142.0 COG0577@1|root,COG0577@2|Bacteria,1MVCT@1224|Proteobacteria,42MX2@68525|delta/epsilon subdivisions,2WIUV@28221|Deltaproteobacteria 28221|Deltaproteobacteria V FtsX-like permease family - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_302998_2 640081.Dsui_0348 1.12e-54 172.0 COG0198@1|root,COG0198@2|Bacteria,1MZQD@1224|Proteobacteria,2VUC6@28216|Betaproteobacteria,2KWPF@206389|Rhodocyclales 206389|Rhodocyclales J One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit rplX - - ko:K02895 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - KOW,ribosomal_L24 k59_302998_3 90813.JQMT01000001_gene226 3.45e-17 78.6 COG0094@1|root,COG0094@2|Bacteria,1MUU9@1224|Proteobacteria,1RPE1@1236|Gammaproteobacteria,460DF@72273|Thiotrichales 72273|Thiotrichales J This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits rplE - - ko:K02931 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L5,Ribosomal_L5_C k59_868190_1 717785.HYPMC_0288 7.05e-20 90.9 COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,2U0IK@28211|Alphaproteobacteria,3N7R1@45401|Hyphomicrobiaceae 28211|Alphaproteobacteria O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner MA20_45155 - 3.4.21.53 ko:K01338 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - AAA,LON_substr_bdg,Lon_C k59_868190_2 395965.Msil_3173 3.81e-09 56.2 COG0071@1|root,COG0071@2|Bacteria,1N7C7@1224|Proteobacteria,2UFRX@28211|Alphaproteobacteria,3NBMX@45404|Beijerinckiaceae 28211|Alphaproteobacteria O Hsp20/alpha crystallin family hspC2 - - ko:K13993 ko04141,map04141 - - - ko00000,ko00001,ko03110 - - - HSP20 k59_132964_1 1499499.EV06_0388 3.71e-45 161.0 COG0769@1|root,COG0769@2|Bacteria,1G0HH@1117|Cyanobacteria,1MM0Z@1212|Prochloraceae 1117|Cyanobacteria M Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan murE - 6.3.2.13 ko:K01928 ko00300,ko00550,map00300,map00550 - R02788 RC00064,RC00090 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_132964_2 859657.RPSI07_0659 5e-16 79.7 COG0770@1|root,COG0770@2|Bacteria,1QTSF@1224|Proteobacteria,2VH2H@28216|Betaproteobacteria,1K0FD@119060|Burkholderiaceae 28216|Betaproteobacteria M Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein murF - 6.3.2.10,6.3.2.13 ko:K01929,ko:K15792 ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502 - R02788,R04573,R04617 RC00064,RC00090,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_527451_1 1229909.NSED_08275 4.44e-17 74.7 arCOG08674@1|root,arCOG08674@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_527451_2 1229909.NSED_08280 2.25e-87 260.0 arCOG08673@1|root,arCOG08673@2157|Archaea,41SVK@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_527451_3 436308.Nmar_1506 1.67e-62 191.0 arCOG08672@1|root,arCOG08672@2157|Archaea,41SU2@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_527451_4 436308.Nmar_1507 1.22e-50 162.0 arCOG10587@1|root,arCOG10587@2157|Archaea,41SVM@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_584632_1 983544.Lacal_2643 1.22e-52 176.0 29SSC@1|root,30DYA@2|Bacteria,4NM51@976|Bacteroidetes,1I24J@117743|Flavobacteriia 976|Bacteroidetes S Protein of unknown function (DUF3822) - - - - - - - - - - - - DUF3822 k59_414992_1 187272.Mlg_1890 2.11e-80 261.0 COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MU0R@1224|Proteobacteria,1RP3T@1236|Gammaproteobacteria,1WXGJ@135613|Chromatiales 135613|Chromatiales G Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate - - 2.7.9.2 ko:K01007 ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200 M00173,M00374 R00199 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - PEP-utilizers,PEP-utilizers_C,PPDK_N k59_1714545_1 1122194.AUHU01000010_gene3140 3.13e-76 250.0 COG1874@1|root,COG1874@2|Bacteria,1NDQP@1224|Proteobacteria,1SDV3@1236|Gammaproteobacteria 1236|Gammaproteobacteria G beta-galactosidase bga2 - 3.2.1.23 ko:K12308 ko00052,map00052 - R01105 RC00452 ko00000,ko00001,ko01000 - - - BetaGal_dom4_5,Glyco_hydro_35 k59_527458_1 1123392.AQWL01000003_gene150 4.99e-10 60.8 COG0068@1|root,COG0068@2|Bacteria,1MVP8@1224|Proteobacteria,2VHS4@28216|Betaproteobacteria,1KSM8@119069|Hydrogenophilales 119069|Hydrogenophilales O HypF finger - - - - - - - - - - - - Acylphosphatase,Sua5_yciO_yrdC,zf-HYPF k59_527458_2 1049564.TevJSym_al00340 1.02e-85 262.0 COG0309@1|root,COG0309@2|Bacteria,1MVCC@1224|Proteobacteria,1RQBE@1236|Gammaproteobacteria,1JA5R@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O AIR synthase related protein, N-terminal domain hypE GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0018193,GO:0018198,GO:0018249,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0046892,GO:0051604,GO:0071704,GO:1901564 - ko:K04655 - - - - ko00000 - - - AIRS,AIRS_C k59_245580_1 1415778.JQMM01000001_gene829 6.39e-39 131.0 COG1544@1|root,COG1544@2|Bacteria,1MZHW@1224|Proteobacteria,1S8U1@1236|Gammaproteobacteria,1J6HN@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J COG1544 Ribosome-associated protein Y (PSrp-1) yhbH GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006417,GO:0006448,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015935,GO:0017148,GO:0019222,GO:0022626,GO:0022627,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0043021,GO:0043022,GO:0043024,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0044877,GO:0045900,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0080090,GO:1990904,GO:2000112,GO:2000113 - ko:K05808 - - - - ko00000,ko03009 - - - Ribosomal_S30AE k59_245580_2 314287.GB2207_10526 9.36e-41 139.0 COG1762@1|root,COG1762@2|Bacteria,1RD0E@1224|Proteobacteria,1S668@1236|Gammaproteobacteria,1J6GA@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria G COG1762 Phosphotransferase system mannitol fructose-specific IIA domain (Ntr-type) ptsN GO:0001932,GO:0001934,GO:0003674,GO:0003824,GO:0004857,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006810,GO:0008047,GO:0008150,GO:0008643,GO:0009401,GO:0009893,GO:0010033,GO:0010243,GO:0010562,GO:0010604,GO:0015144,GO:0016020,GO:0016740,GO:0016772,GO:0016773,GO:0019207,GO:0019209,GO:0019220,GO:0019222,GO:0019887,GO:0022804,GO:0022857,GO:0022898,GO:0030234,GO:0030295,GO:0031323,GO:0031325,GO:0031399,GO:0031401,GO:0032147,GO:0032268,GO:0032270,GO:0032409,GO:0032412,GO:0032879,GO:0033674,GO:0034219,GO:0034762,GO:0034765,GO:0042221,GO:0042325,GO:0042327,GO:0043085,GO:0043086,GO:0043269,GO:0043549,GO:0044092,GO:0044093,GO:0044424,GO:0044444,GO:0044464,GO:0045859,GO:0045860,GO:0045937,GO:0048518,GO:0048522,GO:0050789,GO:0050790,GO:0050794,GO:0050896,GO:0051049,GO:0051171,GO:0051173,GO:0051174,GO:0051179,GO:0051234,GO:0051246,GO:0051247,GO:0051338,GO:0051347,GO:0055085,GO:0060255,GO:0065007,GO:0065009,GO:0071702,GO:0071944,GO:0080090,GO:0090563,GO:0098772,GO:1901698 - ko:K02806 ko02060,map02060 - - - ko00000,ko00001,ko01000,ko02000 - - - PTS_EIIA_2 k59_697762_1 316407.4062408 3.85e-26 103.0 COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,1RNJ1@1236|Gammaproteobacteria,3XMKP@561|Escherichia 1236|Gammaproteobacteria EP Part of the ABC transporter complex GsiABCD involved in glutathione import. Probably responsible for the translocation of the substrate across the membrane gsiC GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 - ko:K13890 ko02010,map02010 M00348 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5.11 - ic_1306.c0916 BPD_transp_1 k59_697762_2 316407.4062409 4.12e-140 400.0 COG1173@1|root,COG1173@2|Bacteria,1MWMX@1224|Proteobacteria,1RNBC@1236|Gammaproteobacteria,3XMH1@561|Escherichia 1236|Gammaproteobacteria EP Part of the ABC transporter complex GsiABCD involved in glutathione import. Probably responsible for the translocation of the substrate across the membrane gsiD GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 - ko:K13891 ko02010,map02010 M00348 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5.11 - iECABU_c1320.ECABU_c08730,iECP_1309.ECP_0846,ic_1306.c0917 BPD_transp_1,OppC_N k59_868212_1 1131266.ARWQ01000009_gene956 3.41e-105 311.0 COG1492@1|root,arCOG00105@2157|Archaea,41SG6@651137|Thaumarchaeota 651137|Thaumarchaeota H Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation cobQ - 6.3.5.10 ko:K02232 ko00860,ko01100,map00860,map01100 M00122 R05225 RC00010,RC01302 ko00000,ko00001,ko00002,ko01000 - - - CbiA k59_923730_1 1415778.JQMM01000001_gene1611 1.41e-45 167.0 COG3170@1|root,COG3170@2|Bacteria,1MXV7@1224|Proteobacteria,1RMM5@1236|Gammaproteobacteria,1J4F9@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria NU COG3170 Tfp pilus assembly protein FimV fimV - - ko:K08086 - - - - ko00000 - - - LysM,TPR_19 k59_1319473_1 1229909.NSED_01760 2.05e-132 378.0 COG2013@1|root,arCOG01907@2157|Archaea,41T1Q@651137|Thaumarchaeota 651137|Thaumarchaeota S Mitochondrial biogenesis AIM24 - - - - - - - - - - - - AIM24 k59_245593_1 1120956.JHZK01000001_gene3242 2.35e-42 147.0 COG1344@1|root,COG1344@2|Bacteria,1MV1N@1224|Proteobacteria,2TUQQ@28211|Alphaproteobacteria 28211|Alphaproteobacteria N Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella flaA GO:0005575,GO:0005576,GO:0005623,GO:0009288,GO:0042995,GO:0043226,GO:0043228,GO:0044464 - ko:K02406 ko02020,ko02040,ko04621,ko04626,ko05132,ko05134,map02020,map02040,map04621,map04626,map05132,map05134 - - - ko00000,ko00001,ko02035 - - - Flagellin_C,Flagellin_N k59_415015_1 1509405.GV67_00330 5.89e-24 105.0 COG2801@1|root,COG2801@2|Bacteria,1MWVQ@1224|Proteobacteria,2TQPC@28211|Alphaproteobacteria,4B700@82115|Rhizobiaceae 28211|Alphaproteobacteria L Winged helix-turn helix - - - - - - - - - - - - HTH_28,HTH_29,HTH_32,rve k59_471589_1 1250005.PHEL85_3387 2.93e-87 261.0 2EYWX@1|root,33S3R@2|Bacteria,4P1TB@976|Bacteroidetes,1I89E@117743|Flavobacteriia,3VXA7@52959|Polaribacter 976|Bacteroidetes - - - - - - - - - - - - - - - k59_697792_1 525246.HMPREF0058_1348 1.89e-47 160.0 COG1175@1|root,COG1175@2|Bacteria,2IF2V@201174|Actinobacteria,4D5YJ@85005|Actinomycetales 201174|Actinobacteria P Binding-protein-dependent transport system inner membrane component - - - ko:K10118 ko02010,map02010 M00196 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.28 - - BPD_transp_1 k59_697792_2 525246.HMPREF0058_1349 1.86e-18 84.0 COG0395@1|root,COG0395@2|Bacteria,2HGCU@201174|Actinobacteria,4D634@85005|Actinomycetales 201174|Actinobacteria P Binding-protein-dependent transport system inner membrane component - - - - - - - - - - - - BPD_transp_1 k59_584671_1 1219035.NT2_07_00230 1.17e-62 204.0 COG1960@1|root,COG1960@2|Bacteria,1MUBH@1224|Proteobacteria,2TSKH@28211|Alphaproteobacteria,2K3NM@204457|Sphingomonadales 204457|Sphingomonadales I Acyl-CoA dehydrogenase, N-terminal domain - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_584671_2 1219035.NT2_07_00220 6.04e-40 138.0 COG3828@1|root,COG3828@2|Bacteria,1QWCA@1224|Proteobacteria,2U1GQ@28211|Alphaproteobacteria,2K19I@204457|Sphingomonadales 204457|Sphingomonadales S Trehalose utilisation - - - ko:K09992 - - - - ko00000 - - - ThuA k59_77482_1 290512.Paes_1871 1.33e-92 290.0 COG1115@1|root,COG1115@2|Bacteria,1FDTJ@1090|Chlorobi 1090|Chlorobi E TIGRFAM amino acid carrier protein - - - ko:K03310 - - - - ko00000 2.A.25 - - Na_Ala_symp k59_1545647_2 717231.Flexsi_0576 3.77e-09 58.5 COG2204@1|root,COG2204@2|Bacteria,2GF35@200930|Deferribacteres 200930|Deferribacteres T PFAM sigma-54 factor interaction domain-containing protein - - - - - - - - - - - - HTH_8,Response_reg,Sigma54_activat k59_584680_1 396588.Tgr7_1220 7.27e-50 170.0 COG1749@1|root,COG1749@2|Bacteria,1MU5J@1224|Proteobacteria,1RMWX@1236|Gammaproteobacteria,1WW6Q@135613|Chromatiales 135613|Chromatiales N basal body rod protein - - - ko:K02390 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - FlaE,Flg_bb_rod,Flg_bbr_C k59_584680_2 477228.YO5_12017 2.11e-28 110.0 COG4787@1|root,COG4787@2|Bacteria,1NZWQ@1224|Proteobacteria,1RNVX@1236|Gammaproteobacteria,1Z0E8@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria N Belongs to the flagella basal body rod proteins family flgF - - ko:K02391 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - Flg_bb_rod,Flg_bbr_C k59_811221_1 105559.Nwat_0284 5.72e-105 311.0 COG0191@1|root,COG0191@2|Bacteria,1MURX@1224|Proteobacteria,1RQUC@1236|Gammaproteobacteria,1WWRH@135613|Chromatiales 135613|Chromatiales G Fructose-bisphosphate aldolase, class II, Calvin cycle subtype - - 4.1.2.13 ko:K01624 ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00003,M00165,M00167,M00344,M00345 R01068,R01070,R01829,R02568 RC00438,RC00439,RC00603,RC00604 ko00000,ko00001,ko00002,ko01000 - - - F_bP_aldolase k59_133031_1 1458427.BAWN01000015_gene990 2.24e-117 340.0 COG1451@1|root,COG1451@2|Bacteria,1MXZU@1224|Proteobacteria,2VNC5@28216|Betaproteobacteria,4AI1Z@80864|Comamonadaceae 28216|Betaproteobacteria S Protein of unknown function DUF45 - - - ko:K07043 - - - - ko00000 - - - DUF45 k59_20123_1 1172188.KB911834_gene4138 2.65e-36 140.0 COG2114@1|root,COG3903@1|root,COG2114@2|Bacteria,COG3903@2|Bacteria,2GIZ1@201174|Actinobacteria,4FE8Z@85021|Intrasporangiaceae 201174|Actinobacteria K Transcriptional regulator - - - - - - - - - - - - Guanylate_cyc,TPR_12 k59_471606_1 436308.Nmar_0491 3.5e-86 262.0 COG0181@1|root,arCOG04299@2157|Archaea,41S6Z@651137|Thaumarchaeota 651137|Thaumarchaeota H Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps hemC - 2.5.1.61 ko:K01749 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R00084 RC02317 ko00000,ko00001,ko00002,ko01000 - - - Porphobil_deam,Porphobil_deamC k59_1658847_1 195105.CN97_19695 3.39e-06 49.3 COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,2TQQJ@28211|Alphaproteobacteria 28211|Alphaproteobacteria P Belongs to the ABC transporter superfamily - - - ko:K10112 ko02010,map02010 M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1 - - ABC_tran,TOBE_2 k59_1658847_2 1266998.ATUJ01000005_gene1067 3.13e-07 56.2 COG1934@1|root,COG1934@2|Bacteria,1MXGA@1224|Proteobacteria,2UCAR@28211|Alphaproteobacteria,2PX3D@265|Paracoccus 28211|Alphaproteobacteria S Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane lptA - - ko:K09774 - - - - ko00000,ko02000 1.B.42.1 - - OstA k59_1093027_1 1122137.AQXF01000004_gene1682 1.09e-40 141.0 COG1028@1|root,COG1028@2|Bacteria,1R413@1224|Proteobacteria,2TW0W@28211|Alphaproteobacteria 28211|Alphaproteobacteria IQ short-chain dehydrogenase - - - - - - - - - - - - adh_short_C2 k59_1093027_2 1122137.AQXF01000004_gene1683 1.43e-65 212.0 COG0428@1|root,COG0428@2|Bacteria,1QZBY@1224|Proteobacteria 1224|Proteobacteria P Predicted permease - - - - - - - - - - - - ArsP_1 k59_303080_1 1229909.NSED_00030 6.9e-93 297.0 COG1615@1|root,arCOG06128@2157|Archaea,41SCS@651137|Thaumarchaeota 651137|Thaumarchaeota S Uncharacterised protein family (UPF0182) - - - ko:K09118 - - - - ko00000 - - - UPF0182 k59_303080_2 436308.Nmar_0066 5.8e-29 112.0 COG1467@1|root,arCOG04110@2157|Archaea,41SCB@651137|Thaumarchaeota 651137|Thaumarchaeota L Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair priS - - ko:K02683 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - DNA_primase_S k59_1601841_1 416348.Hlac_2824 0.000189 51.6 COG3291@1|root,arCOG02508@2157|Archaea,2XUY6@28890|Euryarchaeota 28890|Euryarchaeota P PFAM PKD domain containing protein - - - - - - - - - - - - Beta_helix,PKD,Pilin_N,SdrD_B k59_77502_1 391603.FBALC1_02707 1.42e-27 114.0 COG1472@1|root,COG1472@2|Bacteria,4NE90@976|Bacteroidetes,1HX27@117743|Flavobacteriia 976|Bacteroidetes G Belongs to the glycosyl hydrolase 3 family - - 3.2.1.21 ko:K05349 ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110 - R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040 RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248 ko00000,ko00001,ko01000 - GH3 - Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C k59_811228_1 479433.Caci_3916 1.74e-53 186.0 COG0028@1|root,COG0028@2|Bacteria,2GKGX@201174|Actinobacteria 201174|Actinobacteria EH Belongs to the TPP enzyme family - - - - - - - - - - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_584695_1 246200.SPO2707 6.11e-84 256.0 COG2141@1|root,COG2141@2|Bacteria,1MX64@1224|Proteobacteria,2TV8M@28211|Alphaproteobacteria,4NA6V@97050|Ruegeria 28211|Alphaproteobacteria C Luciferase-like monooxygenase limB - - - - - - - - - - - Bac_luciferase k59_245648_1 1201293.AKXQ01000002_gene1640 3.29e-35 125.0 2C3ZQ@1|root,32SCF@2|Bacteria,1N27R@1224|Proteobacteria,1S4HC@1236|Gammaproteobacteria 1236|Gammaproteobacteria S MEKHLA domain protein - - - - - - - - - - - - MEKHLA k59_245648_2 626887.J057_10916 3.4e-44 150.0 COG0500@1|root,COG2226@2|Bacteria,1MX8I@1224|Proteobacteria,1RMAU@1236|Gammaproteobacteria,464M8@72275|Alteromonadaceae 1236|Gammaproteobacteria H Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2- polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) ubiE GO:0003674,GO:0003824,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008425,GO:0008757,GO:0009058,GO:0009108,GO:0009233,GO:0009234,GO:0009987,GO:0016740,GO:0016741,GO:0030580,GO:0032259,GO:0042180,GO:0042181,GO:0043333,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901661,GO:1901663 2.1.1.163,2.1.1.201 ko:K03183 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116,M00117 R04990,R04993,R06859,R08774,R09736 RC00003,RC01253,RC01662 ko00000,ko00001,ko00002,ko01000 - - iAF1260.b3833,iBWG_1329.BWG_3511,iE2348C_1286.E2348C_4147,iEC042_1314.EC042_4213,iEC55989_1330.EC55989_4310,iECDH10B_1368.ECDH10B_4024,iECDH1ME8569_1439.ECDH1ME8569_3712,iECH74115_1262.ECH74115_5274,iECIAI1_1343.ECIAI1_4028,iECIAI39_1322.ECIAI39_3162,iECO103_1326.ECO103_4330,iECO111_1330.ECO111_4661,iECO26_1355.ECO26_4752,iECSE_1348.ECSE_4121,iECSP_1301.ECSP_4888,iECUMN_1333.ECUMN_4359,iECW_1372.ECW_m4135,iECs_1301.ECs4763,iEKO11_1354.EKO11_4524,iETEC_1333.ETEC_4110,iEcDH1_1363.EcDH1_4146,iEcE24377_1341.EcE24377A_4354,iEcHS_1320.EcHS_A4057,iEcSMS35_1347.EcSMS35_4216,iEcolC_1368.EcolC_4175,iG2583_1286.G2583_4633,iJO1366.b3833,iJR904.b3833,iSBO_1134.SBO_3847,iSDY_1059.SDY_3910,iSFV_1184.SFV_3665,iSF_1195.SF3911,iSFxv_1172.SFxv_4263,iSSON_1240.SSON_4008,iS_1188.S3843,iSbBS512_1146.SbBS512_E4305,iUMNK88_1353.UMNK88_4663,iWFL_1372.ECW_m4135,iY75_1357.Y75_RS17910,iZ_1308.Z5355 Ubie_methyltran k59_1149535_1 1397527.Q670_03335 2.48e-49 172.0 COG1207@1|root,COG1207@2|Bacteria,1MUPH@1224|Proteobacteria,1RNKE@1236|Gammaproteobacteria,1XHJE@135619|Oceanospirillales 135619|Oceanospirillales M Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain glmU - 2.3.1.157,2.7.7.23 ko:K04042 ko00520,ko01100,ko01130,map00520,map01100,map01130 M00362 R00416,R05332 RC00002,RC00004,RC00166 ko00000,ko00001,ko00002,ko01000 - - - Hexapep,NTP_transf_3 k59_584710_1 1336233.JAEH01000040_gene4265 1.87e-60 212.0 COG0834@1|root,COG1301@1|root,COG0834@2|Bacteria,COG1301@2|Bacteria,1P22C@1224|Proteobacteria,1RSGY@1236|Gammaproteobacteria,2QBG7@267890|Shewanellaceae 1236|Gammaproteobacteria P Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family - - - ko:K02030 - M00236 - - ko00000,ko00002,ko02000 3.A.1.3 - - SBP_bac_3,SDF k59_189853_1 314287.GB2207_02352 8.87e-68 214.0 COG0101@1|root,COG0101@2|Bacteria,1MUYI@1224|Proteobacteria,1RMK2@1236|Gammaproteobacteria,1J4NT@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs truA GO:0000049,GO:0001522,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016853,GO:0016866,GO:0031119,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363 5.4.99.12 ko:K06173 - - - - ko00000,ko01000,ko03016 - - - PseudoU_synth_1 k59_1149553_1 580332.Slit_0534 2.69e-85 258.0 COG1234@1|root,COG1234@2|Bacteria,1QU4B@1224|Proteobacteria,2VH0D@28216|Betaproteobacteria,44W4T@713636|Nitrosomonadales 28216|Betaproteobacteria S SMART beta-lactamase domain protein - - 3.1.4.17 ko:K01120 ko00230,map00230 - R00191,R01234 RC00296 ko00000,ko00001,ko01000 - - - Lactamase_B_2 k59_697862_1 1384054.N790_05500 6.02e-99 299.0 COG3191@1|root,COG3191@2|Bacteria,1MWDP@1224|Proteobacteria,1RYNM@1236|Gammaproteobacteria,1X5T4@135614|Xanthomonadales 135614|Xanthomonadales EQ Peptidase family S58 - - - - - - - - - - - - Peptidase_S58 k59_641270_1 765913.ThidrDRAFT_1282 2.19e-103 334.0 COG0587@1|root,COG0587@2|Bacteria,1MUIF@1224|Proteobacteria,1RP0K@1236|Gammaproteobacteria,1WVZ3@135613|Chromatiales 135613|Chromatiales L DNA polymerase III alpha subunit - - 2.7.7.7 ko:K02337 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_alpha,HHH_6,Intein_splicing,LAGLIDADG_3,PHP,tRNA_anti-codon k59_1377601_1 460265.Mnod_6273 9.37e-59 190.0 COG0286@1|root,COG0286@2|Bacteria,1RF3V@1224|Proteobacteria,2U786@28211|Alphaproteobacteria,1JW49@119045|Methylobacteriaceae 28211|Alphaproteobacteria V site-specific DNA-methyltransferase (adenine-specific) activity - - - - - - - - - - - - - k59_869498_1 247633.GP2143_05015 4.04e-100 309.0 COG1022@1|root,COG1022@2|Bacteria,1MU4D@1224|Proteobacteria,1RPNE@1236|Gammaproteobacteria,1J4V9@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria I COG1022 Long-chain acyl-CoA synthetases (AMP-forming) - - - - - - - - - - - - AMP-binding,Haem_oxygenas_2 k59_1432744_1 1122221.JHVI01000011_gene1034 3.28e-34 125.0 COG3415@1|root,COG3415@2|Bacteria,1WNBN@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus L Transposase - - - - - - - - - - - - HTH_23,TniQ k59_304344_1 436308.Nmar_0209 5.37e-68 214.0 arCOG08023@1|root,arCOG08023@2157|Archaea,41SKK@651137|Thaumarchaeota 651137|Thaumarchaeota S Zinc finger domain - - - - - - - - - - - - zinc_ribbon_2 k59_1377612_1 1229909.NSED_04855 3.64e-104 314.0 COG0154@1|root,arCOG01717@2157|Archaea,41SCW@651137|Thaumarchaeota 651137|Thaumarchaeota J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) gatA - 6.3.5.6,6.3.5.7 ko:K02433 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - Amidase k59_134283_1 640081.Dsui_0571 7.52e-18 79.7 COG3411@1|root,COG3411@2|Bacteria,1N0XK@1224|Proteobacteria,2VUIX@28216|Betaproteobacteria,2KX48@206389|Rhodocyclales 206389|Rhodocyclales C Ferredoxin - - - - - - - - - - - - - k59_1432760_1 1122214.AQWH01000005_gene1213 1.33e-18 85.9 COG0179@1|root,COG0179@2|Bacteria,1MUPF@1224|Proteobacteria,2TQQG@28211|Alphaproteobacteria,2PJHD@255475|Aurantimonadaceae 28211|Alphaproteobacteria Q Fumarylacetoacetate (FAA) hydrolase family - - - - - - - - - - - - DUF2437,FAA_hydrolase k59_1432760_2 1267005.KB911258_gene425 1.32e-05 47.4 COG0441@1|root,COG0441@2|Bacteria,1MUP2@1224|Proteobacteria,2TQWI@28211|Alphaproteobacteria,3N646@45401|Hyphomicrobiaceae 28211|Alphaproteobacteria J Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) thrS - 6.1.1.3 ko:K01868 ko00970,map00970 M00359,M00360 R03663 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,TGS,tRNA-synt_2b,tRNA_SAD k59_1207591_2 497321.C664_14424 2.81e-19 90.1 COG3071@1|root,COG3071@2|Bacteria,1MU7A@1224|Proteobacteria,2VK6P@28216|Betaproteobacteria,2KVAI@206389|Rhodocyclales 206389|Rhodocyclales H enzyme of heme biosynthesis hemY - - ko:K02498 - - - - ko00000 - - - HemY_N k59_360958_1 194867.ALBQ01000027_gene2708 1.12e-129 400.0 COG1629@1|root,COG1629@2|Bacteria,COG4771@2|Bacteria,1MV8W@1224|Proteobacteria,2TSUV@28211|Alphaproteobacteria,2JZV0@204457|Sphingomonadales 204457|Sphingomonadales P receptor - - - - - - - - - - - - Plug,TonB_dep_Rec k59_1603114_1 1033802.SSPSH_002133 2.07e-54 179.0 COG0704@1|root,COG0704@2|Bacteria,1MUMI@1224|Proteobacteria,1RMW5@1236|Gammaproteobacteria 1236|Gammaproteobacteria P Plays a role in the regulation of phosphate uptake phoU GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009892,GO:0010563,GO:0010966,GO:0019220,GO:0019222,GO:0031323,GO:0031324,GO:0032879,GO:0034762,GO:0034763,GO:0034765,GO:0034766,GO:0042802,GO:0042803,GO:0043269,GO:0043271,GO:0044070,GO:0044424,GO:0044464,GO:0045936,GO:0046983,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051049,GO:0051051,GO:0051174,GO:0065007,GO:1903792,GO:1903795,GO:1903796,GO:1903959,GO:1903960,GO:2000185,GO:2000186 - ko:K02039 - - - - ko00000 - - - PhoU k59_1150730_1 290397.Adeh_3892 8.82e-45 164.0 COG2366@1|root,COG2366@2|Bacteria,1MVMH@1224|Proteobacteria,42M9A@68525|delta/epsilon subdivisions,2WJ3Y@28221|Deltaproteobacteria,2YUEP@29|Myxococcales 28221|Deltaproteobacteria S Penicillin amidase - - 3.5.1.11 ko:K01434 ko00311,ko01130,map00311,map01130 - R02170 RC00166,RC00328 ko00000,ko00001,ko01000,ko01002 - - - Penicil_amidase k59_699089_1 1144342.PMI40_00507 7.17e-66 215.0 COG1207@1|root,COG1207@2|Bacteria,1MUPH@1224|Proteobacteria,2VH54@28216|Betaproteobacteria,472BG@75682|Oxalobacteraceae 28216|Betaproteobacteria M Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain glmU - 2.3.1.157,2.7.7.23 ko:K04042 ko00520,ko01100,ko01130,map00520,map01100,map01130 M00362 R00416,R05332 RC00002,RC00004,RC00166 ko00000,ko00001,ko00002,ko01000 - - - Hexapep,Hexapep_2,NTP_transf_3 k59_980167_2 1229909.NSED_03370 5.93e-101 305.0 COG1262@1|root,arCOG03517@2157|Archaea,41T1B@651137|Thaumarchaeota 651137|Thaumarchaeota S DinB superfamily - - - - - - - - - - - - DinB_2,FGE-sulfatase k59_1094022_1 1009370.ALO_13759 2.14e-65 220.0 COG1253@1|root,COG1253@2|Bacteria,1TPN0@1239|Firmicutes,4H2XJ@909932|Negativicutes 909932|Negativicutes S CBS domain - - - - - - - - - - - - CBS,CorC_HlyC,DUF21 k59_416354_1 1229909.NSED_00400 2.25e-123 361.0 COG2132@1|root,arCOG03914@2157|Archaea,41T22@651137|Thaumarchaeota 651137|Thaumarchaeota Q Multicopper oxidase - - 1.7.2.1 ko:K00368 ko00910,ko01120,map00910,map01120 M00529 R00783,R00785 RC00086 ko00000,ko00001,ko00002,ko01000 - - - Copper-bind k59_704367_2 754476.Q7A_61 3.27e-16 75.9 COG3167@1|root,COG3167@2|Bacteria,1RBGW@1224|Proteobacteria,1S3XQ@1236|Gammaproteobacteria,460V4@72273|Thiotrichales 72273|Thiotrichales NU Pilus assembly protein, PilO - - - ko:K02664 - - - - ko00000,ko02035,ko02044 - - - PilO k59_26874_1 582402.Hbal_1995 2.72e-67 216.0 COG3146@1|root,COG3146@2|Bacteria,1MU35@1224|Proteobacteria,2TS5I@28211|Alphaproteobacteria,43W5K@69657|Hyphomonadaceae 28211|Alphaproteobacteria S protein conserved in bacteria MA20_36195 - - ko:K09919 - - - - ko00000 - - - FemAB_like k59_26874_2 1463841.JOIR01000035_gene7264 1.5e-07 53.9 COG4247@1|root,COG4247@2|Bacteria,2GJDY@201174|Actinobacteria 201174|Actinobacteria I Phytase - - 3.1.3.8 ko:K01083 ko00562,map00562 - R03371 RC00078 ko00000,ko00001,ko01000 - - - Phytase k59_251807_1 1198114.AciX9_0407 3.01e-50 174.0 COG1220@1|root,COG1220@2|Bacteria,3Y2K2@57723|Acidobacteria,2JIS7@204432|Acidobacteriia 204432|Acidobacteriia O this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis hslU - - ko:K03667 - - - - ko00000,ko03110 - - - AAA_2,ClpB_D2-small k59_251807_2 867903.ThesuDRAFT_00282 3.36e-73 225.0 COG5405@1|root,COG5405@2|Bacteria,1TPXK@1239|Firmicutes,24FS4@186801|Clostridia,3WD7C@538999|Clostridiales incertae sedis 186801|Clostridia O Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery hslV - 3.4.25.2 ko:K01419 - - - - ko00000,ko01000,ko01002 - - - Proteasome k59_251807_3 398513.BBNG_00526 3.42e-37 140.0 COG4974@1|root,COG4974@2|Bacteria,2GNDP@201174|Actinobacteria,4CZCX@85004|Bifidobacteriales 201174|Actinobacteria D Belongs to the 'phage' integrase family. XerC subfamily xerC GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K03733,ko:K04763 - - - - ko00000,ko03036 - - - Phage_int_SAM_1,Phage_integrase k59_531771_1 1122137.AQXF01000002_gene536 9.46e-69 213.0 COG0152@1|root,COG0152@2|Bacteria,1MUR9@1224|Proteobacteria,2TR8D@28211|Alphaproteobacteria 28211|Alphaproteobacteria F Belongs to the SAICAR synthetase family purC - 6.3.2.6 ko:K01923 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04591 RC00064,RC00162 ko00000,ko00001,ko00002,ko01000 - - - SAICAR_synt k59_531771_2 1040987.AZUY01000012_gene5241 2.12e-24 93.6 COG1828@1|root,COG1828@2|Bacteria,1N83G@1224|Proteobacteria,2UF7S@28211|Alphaproteobacteria,43KV4@69277|Phyllobacteriaceae 28211|Alphaproteobacteria F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL purS - 6.3.5.3 ko:K01952 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04463 RC00010,RC01160 ko00000,ko00001,ko00002,ko01000 - - - PurS k59_309602_1 1122137.AQXF01000002_gene315 3.6e-36 133.0 COG0260@1|root,COG0260@2|Bacteria,1MUF9@1224|Proteobacteria,2TQU9@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides pepA GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 3.4.11.1 ko:K01255 ko00480,ko01100,map00480,map01100 - R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 - - - Peptidase_M17,Peptidase_M17_N k59_309602_2 1122137.AQXF01000002_gene314 1.14e-41 140.0 COG2927@1|root,COG2927@2|Bacteria,1RGVC@1224|Proteobacteria,2U94V@28211|Alphaproteobacteria 28211|Alphaproteobacteria L DNA polymerase III, chi subunit holC - 2.7.7.7 ko:K02339 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_chi k59_1496227_1 1144305.PMI02_01724 1.85e-32 119.0 COG1451@1|root,COG1451@2|Bacteria,1MXZU@1224|Proteobacteria,2U1JG@28211|Alphaproteobacteria,2K287@204457|Sphingomonadales 204457|Sphingomonadales S Metal-dependent hydrolase - - - ko:K07043 - - - - ko00000 - - - DUF45 k59_1496227_2 1479239.JQMU01000001_gene1865 1.96e-23 94.4 COG2983@1|root,COG2983@2|Bacteria,1RHMX@1224|Proteobacteria,2U99S@28211|Alphaproteobacteria,2K4JE@204457|Sphingomonadales 204457|Sphingomonadales S Belongs to the UPF0260 family - - - ko:K09160 - - - - ko00000 - - - CxxCxxCC k59_1496231_1 1121921.KB898706_gene2452 6.93e-75 251.0 COG1629@1|root,COG1629@2|Bacteria,COG4771@2|Bacteria,1MV8W@1224|Proteobacteria,1RSN6@1236|Gammaproteobacteria,2PMH6@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria P TonB-dependent Receptor Plug Domain - - - - - - - - - - - - Plug,TonB_dep_Rec k59_928387_2 1178482.BJB45_17290 7.91e-79 261.0 COG1538@1|root,COG2885@1|root,COG1538@2|Bacteria,COG2885@2|Bacteria,1MYX2@1224|Proteobacteria,1RNX1@1236|Gammaproteobacteria,1XIGH@135619|Oceanospirillales 135619|Oceanospirillales MU type I secretion outer membrane protein, TolC - - - ko:K12543 - M00330 - - ko00000,ko00002,ko02000,ko02044 1.B.17,3.A.1.109.4 - - OEP,OmpA,SPOR k59_704391_1 199310.c4612 3.19e-125 366.0 COG2271@1|root,COG2271@2|Bacteria,1MVPS@1224|Proteobacteria,1RNMV@1236|Gammaproteobacteria,3XMSP@561|Escherichia 1236|Gammaproteobacteria P Intake of galactonate into the cell dgoT GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0015711,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0044425,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944 - ko:K03535,ko:K08194,ko:K12299 - - - - ko00000,ko02000 2.A.1.14.1,2.A.1.14.14,2.A.1.14.7 - iECO103_1326.ECO103_4467,iSF_1195.SF3164,iSFxv_1172.SFxv_3474,iSSON_1240.SSON_2946,iS_1188.S3379 MFS_1 k59_704394_1 1048339.KB913029_gene2594 6.22e-10 60.1 COG1168@1|root,COG1168@2|Bacteria,2GJFQ@201174|Actinobacteria,4ESK6@85013|Frankiales 201174|Actinobacteria E PFAM Aminotransferase class I and II aecD GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 4.4.1.8 ko:K00842,ko:K14155 ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230 - R00782,R01286,R02408,R04941 RC00056,RC00069,RC00382,RC00488,RC00710,RC01245,RC02303 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_1_2 k59_1663828_2 1242864.D187_008336 2.34e-36 134.0 COG2038@1|root,COG2038@2|Bacteria,1MVAM@1224|Proteobacteria,42M3Z@68525|delta/epsilon subdivisions,2WJIR@28221|Deltaproteobacteria,2YWFB@29|Myxococcales 28221|Deltaproteobacteria F Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) cobT GO:0003674,GO:0003824,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008939,GO:0009058,GO:0009110,GO:0009235,GO:0009236,GO:0009987,GO:0016740,GO:0016757,GO:0016763,GO:0017144,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042364,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.4.2.21 ko:K00768 ko00860,ko01100,map00860,map01100 M00122 R04148 RC00033,RC00063 ko00000,ko00001,ko00002,ko01000 - - - DBI_PRT k59_1721377_1 518766.Rmar_1948 2.18e-172 493.0 COG3033@1|root,COG3033@2|Bacteria,4NEP4@976|Bacteroidetes,1FJ19@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes E Beta-eliminating lyase tnaA - 4.1.99.1 ko:K01667 ko00380,map00380 - R00673 RC00209,RC00355 ko00000,ko00001,ko01000 - - - Beta_elim_lyase k59_928392_1 1116472.MGMO_134c00040 2.92e-16 77.0 COG0179@1|root,COG0179@2|Bacteria,1MUPF@1224|Proteobacteria,1RPYA@1236|Gammaproteobacteria,1XDVA@135618|Methylococcales 135618|Methylococcales Q Fumarylacetoacetate (FAA) hydrolase family - - - - - - - - - - - - FAA_hydrolase k59_928392_2 366602.Caul_4458 4.18e-57 189.0 COG2207@1|root,COG2207@2|Bacteria,1P1FH@1224|Proteobacteria,2TRGB@28211|Alphaproteobacteria,2KHDI@204458|Caulobacterales 204458|Caulobacterales K AraC-like ligand binding domain - - - - - - - - - - - - AraC_binding,HTH_18 k59_476258_1 234267.Acid_6436 7.63e-67 228.0 COG0457@1|root,COG0457@2|Bacteria,3Y6C4@57723|Acidobacteria 57723|Acidobacteria E Tetratricopeptide repeats - - - - - - - - - - - - TPR_16,TPR_8 k59_366525_1 1437425.CSEC_0326 7.52e-39 139.0 COG3000@1|root,COG3000@2|Bacteria 2|Bacteria I iron ion binding - - - - - - - - - - - - FA_hydroxylase k59_366525_3 999541.bgla_1g36990 8.19e-09 57.4 COG0137@1|root,COG0137@2|Bacteria,1MV0Y@1224|Proteobacteria,2VJ7Z@28216|Betaproteobacteria,1K0VF@119060|Burkholderiaceae 28216|Betaproteobacteria E Belongs to the argininosuccinate synthase family. Type argG GO:0000050,GO:0000053,GO:0003674,GO:0003824,GO:0004055,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006575,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0019627,GO:0019752,GO:0034641,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:0072350,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 6.3.4.5 ko:K01940 ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418 M00029,M00844,M00845 R01954 RC00380,RC00629 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Arginosuc_synth k59_420732_1 1122197.ATWI01000009_gene1447 1.08e-61 199.0 COG0491@1|root,COG0491@2|Bacteria,1MU8Q@1224|Proteobacteria,1S22I@1236|Gammaproteobacteria,466DR@72275|Alteromonadaceae 1236|Gammaproteobacteria S Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid gloB GO:0003674,GO:0003824,GO:0004416,GO:0006518,GO:0006575,GO:0006749,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016788,GO:0016790,GO:0034641,GO:0043603,GO:0044237,GO:0051186,GO:0071704,GO:1901564 3.1.2.6 ko:K01069 ko00620,map00620 - R01736 RC00004,RC00137 ko00000,ko00001,ko01000 - - - HAGH_C,Lactamase_B k59_591149_1 743720.Psefu_1927 2.55e-12 66.6 COG1366@1|root,COG1366@2|Bacteria,1MZ5N@1224|Proteobacteria,1S9QR@1236|Gammaproteobacteria,1YZ4K@136845|Pseudomonas putida group 1236|Gammaproteobacteria T STAS domain rsbV - - ko:K20978 ko02020,ko02025,map02020,map02025 - - - ko00000,ko00001 - - - STAS_2 k59_476270_1 83406.HDN1F_17340 8.52e-46 154.0 COG1569@1|root,COG1569@2|Bacteria,1RCZE@1224|Proteobacteria,1S52X@1236|Gammaproteobacteria 1236|Gammaproteobacteria S PIN domain - - - - - - - - - - - - PIN_3 k59_758621_2 1229909.NSED_09395 1.38e-29 108.0 COG2453@1|root,arCOG03413@2157|Archaea,41SK5@651137|Thaumarchaeota 651137|Thaumarchaeota T Dual specificity phosphatase, catalytic domain - - 3.1.3.16,3.1.3.48 ko:K14165 - - - - ko00000,ko01000,ko01009 - - - DSPc k59_1496278_1 1191523.MROS_0952 8.62e-13 67.8 COG0029@1|root,COG0029@2|Bacteria 2|Bacteria H Catalyzes the oxidation of L-aspartate to iminoaspartate nadB - 1.3.5.1,1.3.5.4,1.4.3.16 ko:K00239,ko:K00244,ko:K00278 ko00020,ko00190,ko00250,ko00620,ko00650,ko00720,ko00760,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,ko05134,map00020,map00190,map00250,map00620,map00650,map00720,map00760,map01100,map01110,map01120,map01130,map01200,map02020,map05134 M00009,M00011,M00115,M00149,M00150,M00173,M00374,M00376 R00357,R00481,R02164 RC00006,RC00045,RC02566 ko00000,ko00001,ko00002,ko01000 - - iJN678.nadB,iSbBS512_1146.nadB FAD_binding_2,Succ_DH_flav_C k59_1382900_2 1158146.KB907121_gene857 8.13e-20 82.0 COG3461@1|root,COG3461@2|Bacteria,1RISX@1224|Proteobacteria,1T0SD@1236|Gammaproteobacteria,1WYKY@135613|Chromatiales 135613|Chromatiales S Evidence 4 Homologs of previously reported genes of - - - ko:K09700 - - - - ko00000 - - - - k59_84052_1 1500890.JQNL01000001_gene3899 6.16e-06 49.3 COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,1RP53@1236|Gammaproteobacteria,1X55J@135614|Xanthomonadales 135614|Xanthomonadales T Histidine kinase fixL - - - - - - - - - - - HATPase_c,HisKA,PAS_4,PAS_9,Response_reg k59_84052_2 321332.CYB_2420 1.17e-33 124.0 COG1899@1|root,COG1899@2|Bacteria,1GCEV@1117|Cyanobacteria,1H3XV@1129|Synechococcus 1117|Cyanobacteria O Hypusine is a modified amino acid found in eukarya and archaea, but as yet - - 2.5.1.46 ko:K00809 - - - - ko00000,ko01000 - - - DS k59_476278_1 1411123.JQNH01000001_gene807 8.07e-49 159.0 COG2764@1|root,COG2764@2|Bacteria,1N0S4@1224|Proteobacteria,2U5A4@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Protein conserved in bacteria - - - ko:K04750 - - - - ko00000 - - - 3-dmu-9_3-mt k59_476278_2 1273538.G159_06460 1.76e-08 53.5 COG3865@1|root,COG3865@2|Bacteria,1TP7B@1239|Firmicutes,4HDPM@91061|Bacilli,26G4V@186818|Planococcaceae 91061|Bacilli S 3-demethylubiquinone-9 3-methyltransferase - - - - - - - - - - - - 3-dmu-9_3-mt k59_420743_2 391603.FBALC1_12962 1.33e-25 96.7 COG2067@1|root,COG2067@2|Bacteria 2|Bacteria I long-chain fatty acid transporting porin activity - - - - - - - - - - - - Toluene_X k59_366551_1 234267.Acid_7087 6.87e-93 291.0 COG1680@1|root,COG1680@2|Bacteria,3Y6F4@57723|Acidobacteria 57723|Acidobacteria V PFAM Beta-lactamase - - 3.4.16.4 ko:K18988 - - - - ko00000,ko01000,ko01002,ko01011 - - - Beta-lactamase,DUF3471 k59_531812_1 1276756.AUEX01000014_gene2934 2.59e-57 200.0 COG0642@1|root,COG0745@1|root,COG0745@2|Bacteria,COG2205@2|Bacteria,1MUY7@1224|Proteobacteria,2VIXT@28216|Betaproteobacteria,4ADJN@80864|Comamonadaceae 28216|Betaproteobacteria T histidine kinase A domain protein - - - - - - - - - - - - HATPase_c,HisKA,Response_reg k59_591173_1 1163409.UUA_14459 3.58e-31 118.0 COG2802@1|root,COG2802@2|Bacteria,1N54S@1224|Proteobacteria,1T15D@1236|Gammaproteobacteria,1XD34@135614|Xanthomonadales 135614|Xanthomonadales S to the N-terminal domain of Lon protease - - - - - - - - - - - - LON_substr_bdg k59_704453_1 1049564.TevJSym_au00010 4.39e-34 135.0 COG4105@1|root,COG4105@2|Bacteria,1QVQ9@1224|Proteobacteria,1RSIG@1236|Gammaproteobacteria,1J8QI@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Tetratricopeptide repeat - - - - - - - - - - - - TPR_16,TPR_6 k59_251890_1 216595.PFLU_2420 3.74e-11 67.4 COG3156@1|root,COG3156@2|Bacteria,1RE52@1224|Proteobacteria,1SQYX@1236|Gammaproteobacteria 1236|Gammaproteobacteria U Type II secretion system protein K gspK - - ko:K02460 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - T2SSK k59_1663878_1 876044.IMCC3088_1255 1.88e-64 206.0 COG1082@1|root,COG1082@2|Bacteria,1Q3WR@1224|Proteobacteria,1S04R@1236|Gammaproteobacteria,1JAIA@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria G Xylose isomerase - - - - - - - - - - - - AP_endonuc_2 k59_1554291_1 1313172.YM304_24260 4.79e-173 496.0 COG0423@1|root,COG0423@2|Bacteria,2GIT3@201174|Actinobacteria,4CMWI@84992|Acidimicrobiia 84992|Acidimicrobiia J Catalyzes the attachment of glycine to tRNA(Gly) glyQS - 6.1.1.14 ko:K01880 ko00970,map00970 M00359,M00360 R03654 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - HGTP_anticodon,tRNA-synt_2b k59_195575_1 644076.SCH4B_0056 7.49e-56 179.0 COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,2TSGZ@28211|Alphaproteobacteria,4NCKA@97050|Ruegeria 28211|Alphaproteobacteria L Transposase IS116/IS110/IS902 family - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_1214103_1 1116369.KB890024_gene1219 6.89e-73 244.0 COG0651@1|root,COG0651@2|Bacteria,1MURB@1224|Proteobacteria,2TRQ2@28211|Alphaproteobacteria,43KPP@69277|Phyllobacteriaceae 28211|Alphaproteobacteria CP Proton-conducting membrane transporter - - - - - - - - - - - - Proton_antipo_M k59_1722830_1 1177928.TH2_06003 3.79e-43 161.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,2TQQE@28211|Alphaproteobacteria,2JQ18@204441|Rhodospirillales 204441|Rhodospirillales NT Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - MCPsignal k59_1554295_1 1112217.PPL19_04645 1.6e-36 127.0 COG1393@1|root,COG1393@2|Bacteria,1MZ4Z@1224|Proteobacteria,1S8XH@1236|Gammaproteobacteria 1236|Gammaproteobacteria P arsenate reductase arsC GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 1.20.4.1 ko:K00537 - - - - ko00000,ko01000 - - - ArsC k59_1554295_2 487521.OCU_49990 1.03e-41 144.0 COG2030@1|root,COG2030@2|Bacteria,2IHRG@201174|Actinobacteria,232WZ@1762|Mycobacteriaceae 201174|Actinobacteria I dehydratase - GO:0003674,GO:0003824,GO:0004300,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0018812,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:0072330,GO:1901576 - - - - - - - - - - MaoC_dehydratas k59_876252_1 1088721.NSU_1200 2.3e-44 158.0 COG0129@1|root,COG0129@2|Bacteria,1MU3T@1224|Proteobacteria,2TQNS@28211|Alphaproteobacteria,2K1X3@204457|Sphingomonadales 204457|Sphingomonadales EG Belongs to the IlvD Edd family - - 4.2.1.12 ko:K01690 ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200 M00008 R02036 RC00543 ko00000,ko00001,ko00002,ko01000 - - - ILVD_EDD k59_876252_2 983920.Y88_0630 2.17e-22 94.7 COG0837@1|root,COG0837@2|Bacteria,1MVFI@1224|Proteobacteria,2U0CA@28211|Alphaproteobacteria,2K0NK@204457|Sphingomonadales 204457|Sphingomonadales G Belongs to the bacterial glucokinase family glk - 2.7.1.2 ko:K00845 ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200 M00001,M00549 R00299,R01600,R01786 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - Glucokinase k59_1554298_1 935863.AWZR01000006_gene1382 1.16e-77 248.0 COG1070@1|root,COG1070@2|Bacteria,1MW4A@1224|Proteobacteria,1RR7X@1236|Gammaproteobacteria,1X4TN@135614|Xanthomonadales 135614|Xanthomonadales G Xylulose kinase xylB - 2.7.1.17 ko:K00854 ko00040,ko01100,map00040,map01100 M00014 R01639 RC00002,RC00538 ko00000,ko00001,ko00002,ko01000 - - - FGGY_C,FGGY_N k59_195580_1 1192034.CAP_2176 8.47e-37 139.0 COG1071@1|root,COG1071@2|Bacteria,1MU5R@1224|Proteobacteria,42NW8@68525|delta/epsilon subdivisions,2WJY1@28221|Deltaproteobacteria,2YY6R@29|Myxococcales 28221|Deltaproteobacteria C Dehydrogenase E1 component bkdA - 1.2.4.1,1.2.4.4 ko:K00161,ko:K00166 ko00010,ko00020,ko00280,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00280,map00620,map00640,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230 M00036,M00307 R00014,R00209,R01699,R03270,R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997 RC00004,RC00027,RC00627,RC02742,RC02743,RC02744,RC02882,RC02883,RC02949,RC02953 br01601,ko00000,ko00001,ko00002,ko01000 - - - E1_dh k59_195580_2 314285.KT71_08279 3.79e-41 141.0 COG1764@1|root,COG1764@2|Bacteria,1RJIP@1224|Proteobacteria,1S6QM@1236|Gammaproteobacteria,1J9ZC@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O redox protein, regulator of disulfide bond formation - - - - - - - - - - - - OsmC k59_195580_3 1437425.CSEC_2010 1.51e-05 52.4 COG2319@1|root,COG2319@2|Bacteria 2|Bacteria S anaphase-promoting complex binding - - - - - - - - - - - - DnaJ,F-box,F-box-like,TPR_1,TPR_11,TPR_2,WD40 k59_929372_1 1089550.ATTH01000001_gene1831 1.23e-29 121.0 COG0515@1|root,COG0515@2|Bacteria,4NPN9@976|Bacteroidetes,1FJI6@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes KLT Protein tyrosine kinase - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - NERD,Pkinase,TPR_12,TPR_8 k59_1214127_1 85643.Tmz1t_3934 2.08e-108 318.0 COG4674@1|root,COG4674@2|Bacteria,1MUBR@1224|Proteobacteria,2VIX4@28216|Betaproteobacteria,2KUB2@206389|Rhodocyclales 206389|Rhodocyclales S Urea ABC transporter ATP-binding protein urtd urtD - - ko:K11962 ko02010,map02010 M00323 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4.4,3.A.1.4.5 - - ABC_tran,BCA_ABC_TP_C k59_646930_1 573.JG24_04110 1.25e-63 209.0 COG0611@1|root,COG0611@2|Bacteria,1MU9X@1224|Proteobacteria,1RNHU@1236|Gammaproteobacteria 1236|Gammaproteobacteria H Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 thiL GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009030,GO:0009058,GO:0009108,GO:0009110,GO:0009228,GO:0009229,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0017076,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0035639,GO:0036094,GO:0042357,GO:0042364,GO:0042723,GO:0042724,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046483,GO:0046872,GO:0051186,GO:0051188,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.7.4.16 ko:K00946 ko00730,ko01100,map00730,map01100 M00127 R00617 RC00002 ko00000,ko00001,ko00002,ko01000 - - iSFV_1184.SFV_0382 AIRS,AIRS_C k59_1664946_1 243231.GSU0234 4.01e-30 114.0 COG2116@1|root,COG2116@2|Bacteria,1MU0W@1224|Proteobacteria,42Q34@68525|delta/epsilon subdivisions,2WN9I@28221|Deltaproteobacteria,43V2M@69541|Desulfuromonadales 28221|Deltaproteobacteria P Formate/nitrite transporter fdhC - - ko:K06212,ko:K21993 - - - - ko00000,ko02000 1.A.16.1.1,1.A.16.1.3,1.A.16.2 - - Form_Nir_trans,Response_reg k59_140835_1 6412.HelroP154313 6.41e-46 160.0 COG1678@1|root,KOG1567@2759|Eukaryota,38B80@33154|Opisthokonta,3B9U0@33208|Metazoa,3CT3A@33213|Bilateria 33208|Metazoa F ribonucleoside-diphosphate reductase activity RRM2B GO:0000002,GO:0000082,GO:0000083,GO:0000278,GO:0001655,GO:0001822,GO:0003008,GO:0003014,GO:0003674,GO:0003824,GO:0004748,GO:0005488,GO:0005506,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005635,GO:0005654,GO:0005737,GO:0005739,GO:0005829,GO:0005971,GO:0006139,GO:0006206,GO:0006259,GO:0006260,GO:0006261,GO:0006264,GO:0006281,GO:0006355,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006919,GO:0006950,GO:0006974,GO:0006979,GO:0006996,GO:0007005,GO:0007049,GO:0007275,GO:0008150,GO:0008152,GO:0008199,GO:0008284,GO:0009058,GO:0009059,GO:0009112,GO:0009117,GO:0009141,GO:0009165,GO:0009200,GO:0009262,GO:0009263,GO:0009790,GO:0009792,GO:0009889,GO:0009893,GO:0009966,GO:0009968,GO:0009987,GO:0010468,GO:0010556,GO:0010564,GO:0010604,GO:0010646,GO:0010648,GO:0010941,GO:0010942,GO:0010948,GO:0010950,GO:0010952,GO:0012505,GO:0016043,GO:0016491,GO:0016725,GO:0016728,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0019637,GO:0022402,GO:0022607,GO:0023051,GO:0023057,GO:0030162,GO:0031323,GO:0031325,GO:0031326,GO:0031967,GO:0031974,GO:0031975,GO:0031981,GO:0032042,GO:0032268,GO:0032270,GO:0032501,GO:0032502,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0042127,GO:0042802,GO:0042803,GO:0042981,GO:0043065,GO:0043066,GO:0043067,GO:0043068,GO:0043069,GO:0043085,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043280,GO:0043281,GO:0043933,GO:0044085,GO:0044093,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044281,GO:0044422,GO:0044424,GO:0044428,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0044770,GO:0044772,GO:0044843,GO:0045786,GO:0045862,GO:0046483,GO:0046872,GO:0046914,GO:0046983,GO:0048513,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048583,GO:0048585,GO:0048731,GO:0048856,GO:0050789,GO:0050790,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0051252,GO:0051259,GO:0051262,GO:0051290,GO:0051291,GO:0051336,GO:0051345,GO:0051716,GO:0051726,GO:0052547,GO:0052548,GO:0055086,GO:0055114,GO:0060255,GO:0060548,GO:0061731,GO:0065003,GO:0065007,GO:0065009,GO:0070013,GO:0070316,GO:0070317,GO:0071704,GO:0071840,GO:0072001,GO:0072527,GO:0080090,GO:0090304,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901576,GO:1901796,GO:1901797,GO:1902253,GO:1902254,GO:1902494,GO:1902531,GO:1902532,GO:1903047,GO:1903506,GO:1990204,GO:2000112,GO:2000116,GO:2001056,GO:2001141,GO:2001233,GO:2001234,GO:2001242,GO:2001243 1.17.4.1 ko:K10808 ko00230,ko00240,ko00480,ko00983,ko01100,ko04115,map00230,map00240,map00480,map00983,map01100,map04115 M00053 R02017,R02019,R02024,R08363,R08364,R11893 RC00613,RC01003 ko00000,ko00001,ko00002,ko01000,ko03400 - - - Ribonuc_red_sm k59_876268_1 67593.Physo109219 1.4e-130 379.0 COG1063@1|root,KOG0024@2759|Eukaryota,3QAUW@4776|Peronosporales 4776|Peronosporales Q Alcohol dehydrogenase GroES-like domain - - - - - - - - - - - - ADH_N,ADH_zinc_N k59_1775881_1 1415778.JQMM01000001_gene589 1.43e-66 217.0 COG0534@1|root,COG0534@2|Bacteria,1MV6B@1224|Proteobacteria,1RPGF@1236|Gammaproteobacteria,1J4H3@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria V COG0534 Na -driven multidrug efflux pump dinF - - ko:K03327 - - - - ko00000,ko02000 2.A.66.1 - - MatE k59_367960_1 1121087.AUCK01000009_gene2135 9.21e-33 124.0 COG1344@1|root,COG1344@2|Bacteria,1TP1K@1239|Firmicutes,4H9UA@91061|Bacilli,1ZAQJ@1386|Bacillus 91061|Bacilli N Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella flaA GO:0005575,GO:0005576,GO:0005623,GO:0009288,GO:0042995,GO:0043226,GO:0043228,GO:0044464 - ko:K02406 ko02020,ko02040,ko04621,ko04626,ko05132,ko05134,map02020,map02040,map04621,map04626,map05132,map05134 - - - ko00000,ko00001,ko02035 - - - Flagellin_C,Flagellin_N k59_816151_2 1217715.F994_00740 3.79e-22 91.3 COG2314@1|root,COG2314@2|Bacteria,1RJJN@1224|Proteobacteria,1S6WP@1236|Gammaproteobacteria,3NQ4Z@468|Moraxellaceae 1236|Gammaproteobacteria S TM2 domain - - - - - - - - - - - - Pilin,TM2 k59_1722874_1 1096930.L284_15300 1.23e-137 393.0 COG1806@1|root,COG1806@2|Bacteria,1MUHU@1224|Proteobacteria,2TT66@28211|Alphaproteobacteria,2K0GA@204457|Sphingomonadales 204457|Sphingomonadales S Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation - - 2.7.11.33,2.7.4.28 ko:K09773 - - - - ko00000,ko01000 - - - Kinase-PPPase k59_1156481_1 999141.GME_13550 6.26e-146 422.0 COG0304@1|root,COG0304@2|Bacteria,1MU1X@1224|Proteobacteria,1RMDE@1236|Gammaproteobacteria,1XHMY@135619|Oceanospirillales 135619|Oceanospirillales IQ catalyzes a condensation reaction in fatty acid biosynthesis addition of an acyl acceptor of two carbons from malonyl-ACP fabB - 2.3.1.41 ko:K00647 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119 RC00039,RC02728,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Ketoacyl-synt_C,ketoacyl-synt k59_1156481_2 1286106.MPL1_01483 2.81e-16 74.3 COG0764@1|root,COG0764@2|Bacteria,1MWV8@1224|Proteobacteria,1RP6W@1236|Gammaproteobacteria,460E0@72273|Thiotrichales 72273|Thiotrichales I Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length fabA - 4.2.1.59,5.3.3.14 ko:K01716 ko00061,ko01100,ko01212,map00061,map01100,map01212 M00083 R04428,R04535,R04537,R04544,R04568,R04954,R04965,R07639 RC00831,RC01078,RC01095 ko00000,ko00001,ko00002,ko01000,ko01004 - - - FabA k59_1554343_1 335543.Sfum_3755 3.7e-49 172.0 COG5421@1|root,COG5421@2|Bacteria,1Q09R@1224|Proteobacteria,437PJ@68525|delta/epsilon subdivisions,2WYMZ@28221|Deltaproteobacteria,2MRCG@213462|Syntrophobacterales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_477295_1 384765.SIAM614_12383 7.57e-23 102.0 COG3562@1|root,COG3562@2|Bacteria,1MUZT@1224|Proteobacteria,2TQM3@28211|Alphaproteobacteria 28211|Alphaproteobacteria M Capsule polysaccharide rkpJ - - ko:K07265 - - - - ko00000 - - - Capsule_synth k59_253254_1 670307.HYPDE_33273 5.76e-08 59.3 COG2304@1|root,COG4733@1|root,COG2304@2|Bacteria,COG4733@2|Bacteria,1REJW@1224|Proteobacteria,2UT75@28211|Alphaproteobacteria 28211|Alphaproteobacteria S von Willebrand factor type A domain - - - - - - - - - - - - - k59_1268356_1 1205680.CAKO01000038_gene1692 8.19e-44 154.0 COG0526@1|root,COG0526@2|Bacteria,1P3KS@1224|Proteobacteria 1224|Proteobacteria CO COG0526, thiol-disulfide isomerase and thioredoxins - - - - - - - - - - - - - k59_477304_1 1408418.JNJH01000054_gene406 2.69e-67 213.0 COG0235@1|root,COG0235@2|Bacteria,1MWP9@1224|Proteobacteria,2TRMV@28211|Alphaproteobacteria,2JRJV@204441|Rhodospirillales 204441|Rhodospirillales G COG0235 Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases - - - - - - - - - - - - Aldolase_II k59_759614_1 316407.85675783 4.5e-126 378.0 COG2225@1|root,COG2225@2|Bacteria,1MVEV@1224|Proteobacteria,1RPVI@1236|Gammaproteobacteria,3XP66@561|Escherichia 1236|Gammaproteobacteria C Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA glcB GO:0000287,GO:0003674,GO:0003824,GO:0004474,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006082,GO:0008150,GO:0008152,GO:0009056,GO:0009436,GO:0009987,GO:0016054,GO:0016740,GO:0016746,GO:0019752,GO:0032787,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046185,GO:0046395,GO:0046487,GO:0046872,GO:0046912,GO:0071704,GO:0072329,GO:1901575 2.3.3.9 ko:K01638 ko00620,ko00630,ko01100,ko01110,ko01120,ko01200,map00620,map00630,map01100,map01110,map01120,map01200 M00012 R00472 RC00004,RC00308,RC02747 ko00000,ko00001,ko00002,ko01000 - - iECSF_1327.ECSF_2799,iECW_1372.ECW_m3242,iEKO11_1354.EKO11_0745,iWFL_1372.ECW_m3242 Malate_synthase k59_1046012_1 639283.Snov_0368 4.64e-62 212.0 COG0045@1|root,COG1042@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,1MW98@1224|Proteobacteria,2TR24@28211|Alphaproteobacteria,3F0K6@335928|Xanthobacteraceae 28211|Alphaproteobacteria CK CoA-binding domain protein - - - ko:K09181 - - - - ko00000 - - - ATP-grasp_5,Acetyltransf_1,CoA_binding_2,Succ_CoA_lig k59_1384315_1 1485544.JQKP01000002_gene1516 1.24e-151 439.0 COG0439@1|root,COG0439@2|Bacteria,1MU4H@1224|Proteobacteria,2VISB@28216|Betaproteobacteria,44VMS@713636|Nitrosomonadales 28216|Betaproteobacteria I PFAM Carbamoyl-phosphate synthase L chain ATP-binding accC GO:0003674,GO:0003824,GO:0004075,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0016053,GO:0016874,GO:0016879,GO:0019216,GO:0019217,GO:0019222,GO:0019752,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032787,GO:0042304,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046394,GO:0046890,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051055,GO:0062012,GO:0062014,GO:0065007,GO:0071704,GO:0072330,GO:0080090,GO:1901576 6.3.4.14,6.4.1.2 ko:K01961 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04385 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 - - - Biotin_carb_C,Biotin_carb_N,CPSase_L_D2 k59_1775904_1 1192759.AKIB01000069_gene3860 3.37e-142 414.0 COG0277@1|root,COG0277@2|Bacteria,1MY08@1224|Proteobacteria 1224|Proteobacteria C PFAM FAD linked oxidase domain protein - - 1.1.3.15,1.17.99.1 ko:K00104,ko:K05797 ko00623,ko00630,ko01100,ko01110,ko01120,ko01130,map00623,map00630,map01100,map01110,map01120,map01130 - R00475,R02675,R11194 RC00042,RC00769 ko00000,ko00001,ko01000 - - - FAD-oxidase_C,FAD_binding_4 k59_876305_2 309807.SRU_1818 1.33e-21 87.8 COG0229@1|root,COG0229@2|Bacteria,4NQEY@976|Bacteroidetes,1FK4M@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes C SelR domain msrB - 1.8.4.12 ko:K07305 - - - - ko00000,ko01000 - - - SelR k59_881897_2 1266908.AQPB01000060_gene264 2.43e-35 134.0 COG0665@1|root,COG0665@2|Bacteria,1MVIZ@1224|Proteobacteria,1RQ50@1236|Gammaproteobacteria,1WXU5@135613|Chromatiales 135613|Chromatiales E D-amino acid dadA - 1.4.5.1 ko:K00285 ko00360,map00360 - R01374,R09493 RC00006,RC00025 ko00000,ko00001,ko01000 - - - DAO k59_90293_1 1440053.JOEI01000011_gene4667 3.53e-26 108.0 COG1117@1|root,COG1117@2|Bacteria,2GJQ3@201174|Actinobacteria 201174|Actinobacteria P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system pstB - 3.6.3.27 ko:K02036 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.7 - - ABC_tran k59_933565_1 1088721.NSU_0214 6.23e-51 177.0 COG0477@1|root,COG2814@2|Bacteria,1MU1I@1224|Proteobacteria,2TVXT@28211|Alphaproteobacteria,2JZYF@204457|Sphingomonadales 204457|Sphingomonadales EGP Major facilitator superfamily - - - ko:K03446 - M00701 - - ko00000,ko00002,ko02000 2.A.1.3 - - MFS_1 k59_201193_1 1229909.NSED_07310 1.72e-216 620.0 COG1205@1|root,arCOG08693@1|root,arCOG00555@2157|Archaea,arCOG08693@2157|Archaea,41SZS@651137|Thaumarchaeota 651137|Thaumarchaeota L DEAD DEAH box helicase - - - ko:K06877 - - - - ko00000 - - - DEAD,DUF1998,Helicase_C k59_258862_1 926569.ANT_04530 2.38e-90 288.0 COG0542@1|root,COG0542@2|Bacteria,2G5RA@200795|Chloroflexi 200795|Chloroflexi O ATPase AAA-2 domain protein clpC - - ko:K03696 ko01100,map01100 - - - ko00000,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N,HTH_17,UVR k59_989260_1 472759.Nhal_3848 1.44e-71 228.0 COG1459@1|root,COG1459@2|Bacteria,1MV4U@1224|Proteobacteria,1RNV0@1236|Gammaproteobacteria,1WWAB@135613|Chromatiales 135613|Chromatiales U Type II secretion system - - - ko:K02653 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSF k59_258870_1 998088.B565_1386 2.01e-34 126.0 COG0217@1|root,COG0217@2|Bacteria,1MW3X@1224|Proteobacteria,1RP5N@1236|Gammaproteobacteria,1Y3EC@135624|Aeromonadales 135624|Aeromonadales K Transcriptional regulatory protein - - - - - - - - - - - - Transcrip_reg k59_258870_2 999141.GME_16122 1.49e-08 55.1 COG0817@1|root,COG0817@2|Bacteria,1MUJI@1224|Proteobacteria,1RQPJ@1236|Gammaproteobacteria,1XJW7@135619|Oceanospirillales 135619|Oceanospirillales L Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group ruvC - 3.1.22.4 ko:K01159 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - RuvC k59_881933_1 648757.Rvan_0957 4.2e-05 46.2 COG0632@1|root,COG0632@2|Bacteria,1MWJR@1224|Proteobacteria,2TSKM@28211|Alphaproteobacteria,3N6TD@45401|Hyphomicrobiaceae 28211|Alphaproteobacteria L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB ruvA GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0050896,GO:0051716,GO:0071496 3.6.4.12 ko:K03550 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - HHH_5,RuvA_C,RuvA_N k59_881933_2 1123257.AUFV01000002_gene2628 6.7e-18 82.0 COG0817@1|root,COG0817@2|Bacteria,1MUJI@1224|Proteobacteria,1RQPJ@1236|Gammaproteobacteria,1X685@135614|Xanthomonadales 135614|Xanthomonadales L Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group ruvC GO:0000725,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008821,GO:0009058,GO:0009059,GO:0009987,GO:0016787,GO:0016788,GO:0016889,GO:0016894,GO:0031297,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0045005,GO:0046483,GO:0048476,GO:0050896,GO:0051716,GO:0071704,GO:0071932,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901576 3.1.22.4 ko:K01159 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - RuvC k59_1161864_1 1232683.ADIMK_2048 3.99e-92 296.0 COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,1SP6I@1236|Gammaproteobacteria,464J4@72275|Alteromonadaceae 1236|Gammaproteobacteria P Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family cusA - - ko:K07787 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.6.1.4 - - ACR_tran k59_933576_1 83406.HDN1F_02580 1.82e-151 449.0 COG1053@1|root,COG1053@2|Bacteria,1MURY@1224|Proteobacteria,1RNYN@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Succinate dehydrogenase fumarate reductase, flavoprotein subunit - - 1.3.99.4 ko:K05898 ko00984,ko01100,ko01120,map00984,map01100,map01120 - R09884 RC00991 ko00000,ko00001,ko01000 - - - FAD_binding_2 k59_933576_2 1127673.GLIP_1357 3.88e-39 143.0 COG4638@1|root,COG4638@2|Bacteria,1MWU3@1224|Proteobacteria,1RRQS@1236|Gammaproteobacteria,469Y0@72275|Alteromonadaceae 1236|Gammaproteobacteria P Rieske [2Fe-2S] domain - - 1.14.13.142 ko:K15982 ko00984,ko01100,ko01120,map00984,map01100,map01120 - R09860 RC02691 ko00000,ko00001,ko01000 - - - Rieske k59_821566_1 1410638.JHXJ01000010_gene169 6.25e-06 53.5 COG2730@1|root,COG2730@2|Bacteria,1TSJQ@1239|Firmicutes,247IR@186801|Clostridia,3WHCE@541000|Ruminococcaceae 186801|Clostridia G Belongs to the glycosyl hydrolase 5 (cellulase A) family - - 3.2.1.4 ko:K01179 ko00500,ko01100,map00500,map01100 - R06200,R11307,R11308 - ko00000,ko00001,ko01000 - GH5,GH9 - Cellulase k59_1050889_1 857087.Metme_2588 2.91e-115 352.0 COG0323@1|root,COG0323@2|Bacteria,1MV61@1224|Proteobacteria,1RM89@1236|Gammaproteobacteria,1XDJ5@135618|Methylococcales 135618|Methylococcales L This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex mutL - - ko:K03572 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - DNA_mis_repair,HATPase_c_3,MutL_C k59_1050889_2 754477.Q7C_1668 2.22e-43 156.0 COG0860@1|root,COG0860@2|Bacteria,1MUQK@1224|Proteobacteria,1RMP1@1236|Gammaproteobacteria,460CG@72273|Thiotrichales 72273|Thiotrichales M N-acetylmuramoyl-L-alanine amidase - - 3.5.1.28 ko:K01448 ko01503,map01503 M00727 R04112 RC00064,RC00141 ko00000,ko00001,ko00002,ko01000,ko01011,ko03036 - - - AMIN,Amidase_3,LysM k59_1560410_1 1173027.Mic7113_2390 6.41e-108 333.0 COG1505@1|root,COG1505@2|Bacteria,1G1B7@1117|Cyanobacteria,1H87F@1150|Oscillatoriales 1117|Cyanobacteria E PFAM Prolyl oligopeptidase, N-terminal beta-propeller domain - - 3.4.21.26 ko:K01322 ko04614,map04614 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_S9,Peptidase_S9_N k59_989276_1 43354.JOIJ01000002_gene4436 2.14e-53 179.0 COG1024@1|root,COG1024@2|Bacteria,2GJ7Z@201174|Actinobacteria,4DY55@85010|Pseudonocardiales 201174|Actinobacteria I Enoyl-CoA hydratase/isomerase - - 5.3.3.18 ko:K15866 ko00360,ko01120,map00360,map01120 - R09837,R09839 RC00004,RC00326,RC02689,RC03003 ko00000,ko00001,ko01000 - - - ECH_1 k59_1390180_1 1115512.EH105704_01_00260 4.95e-92 273.0 COG0605@1|root,COG0605@2|Bacteria,1MVW2@1224|Proteobacteria,1RP7X@1236|Gammaproteobacteria,3XN20@561|Escherichia 1236|Gammaproteobacteria C radicals which are normally produced within the cells and which are toxic to biological systems sodB GO:0000302,GO:0000303,GO:0000305,GO:0003674,GO:0003824,GO:0004784,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006801,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0010035,GO:0016209,GO:0016491,GO:0016721,GO:0019430,GO:0033554,GO:0034599,GO:0034614,GO:0042221,GO:0043167,GO:0043169,GO:0044237,GO:0044424,GO:0044464,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0071450,GO:0071451,GO:0072593,GO:0097237,GO:0098754,GO:0098869,GO:1901700,GO:1901701,GO:1990748 1.15.1.1 ko:K04564 ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016 - - - ko00000,ko00001,ko01000 - - iAF1260.b1656,iAPECO1_1312.APECO1_736,iB21_1397.B21_01616,iBWG_1329.BWG_1471,iE2348C_1286.E2348C_1742,iEC042_1314.EC042_1825,iEC55989_1330.EC55989_1824,iECABU_c1320.ECABU_c19090,iECBD_1354.ECBD_1987,iECB_1328.ECB_01626,iECDH10B_1368.ECDH10B_1790,iECDH1ME8569_1439.ECDH1ME8569_1601,iECD_1391.ECD_01626,iECED1_1282.ECED1_1855,iECH74115_1262.ECH74115_2368,iECIAI1_1343.ECIAI1_1708,iECO103_1326.ECO103_1797,iECO111_1330.ECO111_2126,iECO26_1355.ECO26_2385,iECOK1_1307.ECOK1_1775,iECP_1309.ECP_1601,iECS88_1305.ECS88_1705,iECSE_1348.ECSE_1780,iECSP_1301.ECSP_2222,iECUMN_1333.ECUMN_1946,iECW_1372.ECW_m1823,iECs_1301.ECs2365,iEKO11_1354.EKO11_2118,iETEC_1333.ETEC_1691,iEcDH1_1363.EcDH1_1984,iEcE24377_1341.EcE24377A_1869,iEcHS_1320.EcHS_A1735,iEcSMS35_1347.EcSMS35_1542,iEcolC_1368.EcolC_1973,iG2583_1286.G2583_2051,iJO1366.b1656,iJR904.b1656,iLF82_1304.LF82_2148,iNRG857_1313.NRG857_08300,iSBO_1134.SBO_1475,iSDY_1059.SDY_1882,iSFV_1184.SFV_1678,iSF_1195.SF1684,iSFxv_1172.SFxv_1892,iSSON_1240.SSON_1500,iS_1188.S1816,iSbBS512_1146.SbBS512_E1853,iUMN146_1321.UM146_08870,iUMNK88_1353.UMNK88_2117,iUTI89_1310.UTI89_C1847,iWFL_1372.ECW_m1823,iY75_1357.Y75_RS08680,iZ_1308.Z2678,ic_1306.c2050 Sod_Fe_C,Sod_Fe_N k59_1560425_1 999541.bgla_1g03190 1.75e-44 147.0 COG0256@1|root,COG0256@2|Bacteria,1RGY7@1224|Proteobacteria,2VSH0@28216|Betaproteobacteria,1K7WM@119060|Burkholderiaceae 28216|Betaproteobacteria J This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance rplR - - ko:K02881 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L18p k59_1560425_2 1288494.EBAPG3_29970 2.95e-13 66.6 COG0098@1|root,COG0098@2|Bacteria,1MUS4@1224|Proteobacteria,2VQ80@28216|Betaproteobacteria,3723A@32003|Nitrosomonadales 28216|Betaproteobacteria J Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body rpsE - - ko:K02988 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S5,Ribosomal_S5_C k59_1219055_1 1423747.BAMJ01000002_gene248 2.12e-24 99.8 COG0276@1|root,COG0276@2|Bacteria,1TPKF@1239|Firmicutes,4HAYG@91061|Bacilli,3F4VU@33958|Lactobacillaceae 91061|Bacilli H Catalyzes the ferrous insertion into protoporphyrin IX hemH - 4.99.1.1,4.99.1.9 ko:K01772 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R00310,R11329 RC01012 ko00000,ko00001,ko00002,ko01000 - - - Ferrochelatase k59_1669204_1 95619.PM1_0211090 1.05e-48 175.0 COG1574@1|root,COG1574@2|Bacteria,1MWP2@1224|Proteobacteria,1RNB7@1236|Gammaproteobacteria 1236|Gammaproteobacteria S metal-dependent hydrolase with the TIM-barrel fold - - - - - - - - - - - - Amidohydro_3 k59_711544_1 757424.Hsero_2164 3.51e-06 54.3 COG0840@1|root,COG4564@1|root,COG0840@2|Bacteria,COG4564@2|Bacteria,1MU9B@1224|Proteobacteria,2VGZ8@28216|Betaproteobacteria,475YA@75682|Oxalobacteraceae 28216|Betaproteobacteria NT methyl-accepting chemotaxis - - - ko:K03406,ko:K03776,ko:K05874 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - 4HB_MCP_1,HAMP,MCPsignal,sCache_2 k59_1560433_1 360910.BAV1541 6.68e-30 124.0 COG0658@1|root,COG2333@1|root,COG0658@2|Bacteria,COG2333@2|Bacteria,1MUKF@1224|Proteobacteria,2VHKP@28216|Betaproteobacteria,3T2JS@506|Alcaligenaceae 28216|Betaproteobacteria S Competence protein comA - - ko:K02238 - M00429 - - ko00000,ko00002,ko02044 3.A.11.1,3.A.11.2 - - Competence,DUF4131,Lactamase_B k59_881972_1 1042377.AFPJ01000029_gene552 9.12e-15 78.2 COG0642@1|root,COG2205@2|Bacteria,1N17V@1224|Proteobacteria,1RNFK@1236|Gammaproteobacteria,4647A@72275|Alteromonadaceae 1236|Gammaproteobacteria T COG0642 Signal transduction histidine kinase - - 2.7.13.3 ko:K07641 ko02020,map02020 M00449 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA k59_881972_2 1056820.KB900629_gene1654 3.38e-74 228.0 COG0745@1|root,COG0745@2|Bacteria,1MVCB@1224|Proteobacteria,1RM87@1236|Gammaproteobacteria,2PMM9@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria T Transcriptional regulatory protein, C terminal chvI GO:0000976,GO:0000984,GO:0000986,GO:0000987,GO:0001017,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0005488,GO:0005515,GO:0006355,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0042802,GO:0043565,GO:0044212,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2001141 - ko:K02483,ko:K07663 ko02020,map02020 M00449 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Trans_reg_C k59_1560436_1 1120963.KB894495_gene3278 3.02e-06 53.5 28JNG@1|root,2Z9ES@2|Bacteria,1N32V@1224|Proteobacteria,1S9AH@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - pgsW - - - - - - - - - - - - k59_425820_1 1384054.N790_11315 1.3e-71 229.0 COG0148@1|root,COG0148@2|Bacteria,1MU1N@1224|Proteobacteria,1RNQA@1236|Gammaproteobacteria,1X2YM@135614|Xanthomonadales 135614|Xanthomonadales G Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis eno - 4.2.1.11 ko:K01689 ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066 M00001,M00002,M00003,M00346,M00394 R00658 RC00349 ko00000,ko00001,ko00002,ko01000,ko03019,ko04147 - - - Enolase_C,Enolase_N k59_258929_1 765913.ThidrDRAFT_4551 2.58e-79 247.0 COG0842@1|root,COG0842@2|Bacteria,1MW5R@1224|Proteobacteria,1RPB4@1236|Gammaproteobacteria,1WXQP@135613|Chromatiales 135613|Chromatiales U PFAM ABC-2 type transporter - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_3 k59_598416_1 1280949.HAD_15627 9.82e-63 205.0 COG3004@1|root,COG3004@2|Bacteria,1MW15@1224|Proteobacteria,2TSI5@28211|Alphaproteobacteria,43XAX@69657|Hyphomonadaceae 28211|Alphaproteobacteria P Na( ) H( ) antiporter that extrudes sodium in exchange for external protons nhaA - - ko:K03313 - - - - ko00000,ko02000 2.A.33.1 - - Na_H_antiport_1 k59_1560457_1 1144305.PMI02_00858 1.12e-95 288.0 KOG1110@1|root,2Z8YY@2|Bacteria,1QTHN@1224|Proteobacteria,2U6MZ@28211|Alphaproteobacteria,2K90P@204457|Sphingomonadales 204457|Sphingomonadales S Protein of unknown function (DUF1838) - - - - - - - - - - - - DUF1838 k59_1329151_1 555793.WSK_0163 2.87e-107 328.0 COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,2TS19@28211|Alphaproteobacteria,2K0F8@204457|Sphingomonadales 204457|Sphingomonadales F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides nrdA - 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - Ribonuc_red_lgC,Ribonuc_red_lgN k59_90352_1 1528106.JRJE01000006_gene1001 1.61e-06 53.1 COG2211@1|root,COG2211@2|Bacteria,1MVUM@1224|Proteobacteria,2U1DI@28211|Alphaproteobacteria,2JPI7@204441|Rhodospirillales 204441|Rhodospirillales G Major facilitator superfamily - - - - - - - - - - - - MFS_2 k59_1219919_1 1089552.KI911559_gene1361 7.19e-35 123.0 COG2080@1|root,COG2080@2|Bacteria,1RD8C@1224|Proteobacteria,2U6Z6@28211|Alphaproteobacteria,2JSHT@204441|Rhodospirillales 204441|Rhodospirillales C [2Fe-2S] binding domain - - - - - - - - - - - - Fer2,Fer2_2 k59_1219919_2 1894.JOER01000001_gene5187 7.07e-17 89.7 COG0477@1|root,COG2814@2|Bacteria,2I2IS@201174|Actinobacteria 201174|Actinobacteria EGP Major facilitator superfamily - - - - - - - - - - - - MFS_1,MFS_3 k59_318337_1 1229909.NSED_08130 1.09e-117 353.0 COG1012@1|root,arCOG01252@2157|Archaea,41T12@651137|Thaumarchaeota 651137|Thaumarchaeota C Aldehyde dehydrogenase family - - 1.2.1.88 ko:K00294 ko00250,ko00330,ko01100,map00250,map00330,map01100 - R00245,R00707,R00708,R04444,R04445,R05051 RC00080,RC00216,RC00242,RC00255 ko00000,ko00001,ko01000 - - - Aldedh k59_1504544_1 1151116.Q7S_08680 9.16e-18 82.8 COG0582@1|root,COG0582@2|Bacteria,1MX7E@1224|Proteobacteria,1RNX5@1236|Gammaproteobacteria,3FI3D@34037|Rahnella 1236|Gammaproteobacteria L Belongs to the 'phage' integrase family intE - - - - - - - - - - - Arm-DNA-bind_1,Phage_integrase k59_1504544_3 743299.Acife_1993 1.54e-65 207.0 COG1475@1|root,COG1475@2|Bacteria,1R5VN@1224|Proteobacteria,1RZ7C@1236|Gammaproteobacteria 1236|Gammaproteobacteria K ParB-like nuclease domain ybdM - - - - - - - - - - - ParBc k59_1504544_4 1298593.TOL_0508 1.66e-08 61.6 2BJAB@1|root,32DK6@2|Bacteria,1NI0E@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_712810_1 448385.sce2560 3.06e-09 62.8 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,2YU4Y@29|Myxococcales 28221|Deltaproteobacteria T Two component, sigma54 specific, transcriptional regulator, Fis family - - - ko:K07712 ko02020,map02020 M00497 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_35259_1 391625.PPSIR1_24364 1.69e-101 308.0 COG0714@1|root,COG0714@2|Bacteria,1MUFN@1224|Proteobacteria,42NCX@68525|delta/epsilon subdivisions,2WIYY@28221|Deltaproteobacteria,2YWP3@29|Myxococcales 28221|Deltaproteobacteria S ATPase family associated with various cellular activities (AAA) - - - ko:K03924 - - - - ko00000,ko01000 - - - AAA_3 k59_202498_1 876044.IMCC3088_1281 8.09e-51 179.0 COG0058@1|root,COG0058@2|Bacteria,1MW4J@1224|Proteobacteria,1RN8P@1236|Gammaproteobacteria 1236|Gammaproteobacteria G Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties glgP - 2.4.1.1 ko:K00688 ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931 - R02111 - ko00000,ko00001,ko01000 - GT35 - Phosphorylase k59_202498_2 999541.bgla_2g26330 1.58e-80 265.0 COG1523@1|root,COG1523@2|Bacteria,1MU19@1224|Proteobacteria,2VH8E@28216|Betaproteobacteria,1K1A3@119060|Burkholderiaceae 28216|Betaproteobacteria G Belongs to the glycosyl hydrolase 13 family glgX - 3.2.1.68 ko:K01214 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R09995,R11261 - ko00000,ko00001,ko00002,ko01000 - CBM48,GH13 - Alpha-amylase,CBM_48 k59_934605_2 1242864.D187_006069 2.05e-58 205.0 COG2960@1|root,COG2960@2|Bacteria,1RGT9@1224|Proteobacteria,438RG@68525|delta/epsilon subdivisions,2X3YF@28221|Deltaproteobacteria,2YXKH@29|Myxococcales 28221|Deltaproteobacteria S Protein of unknown function (DUF1552) - - - - - - - - - - - - HXXSHH k59_260179_1 485913.Krac_2717 1.99e-06 60.5 COG3629@1|root,COG3899@1|root,COG3629@2|Bacteria,COG3899@2|Bacteria,2G871@200795|Chloroflexi 200795|Chloroflexi K Transcriptional activator domain - - - - - - - - - - - - AAA_16,BTAD,Trans_reg_C k59_260179_2 335541.Swol_1544 1.67e-13 73.2 arCOG09742@1|root,2ZBGR@2|Bacteria,1V0RW@1239|Firmicutes,24AYH@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - k59_1163167_1 926550.CLDAP_13930 1.02e-45 162.0 COG1062@1|root,COG1062@2|Bacteria,2G7KZ@200795|Chloroflexi 200795|Chloroflexi C Zinc-binding dehydrogenase - - 1.1.1.1,1.1.1.284 ko:K00121 ko00010,ko00071,ko00350,ko00625,ko00626,ko00680,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,ko05204,map00010,map00071,map00350,map00625,map00626,map00680,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01200,map01220,map05204 - R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R06983,R07105,R08281,R08306,R08310 RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01715,RC01734,RC02273 ko00000,ko00001,ko01000 - - - ADH_N,ADH_zinc_N k59_1670142_1 985665.HPL003_13040 2.5e-58 192.0 COG0549@1|root,COG0549@2|Bacteria,1TP9H@1239|Firmicutes,4H9QD@91061|Bacilli,26TXN@186822|Paenibacillaceae 91061|Bacilli E Belongs to the carbamate kinase family cpkA - 2.7.2.2 ko:K00926 ko00220,ko00230,ko00910,ko01100,ko01120,ko01200,map00220,map00230,map00910,map01100,map01120,map01200 - R00150,R01395 RC00002,RC00043,RC02803,RC02804 ko00000,ko00001,ko01000 - - - AA_kinase k59_1104476_1 452637.Oter_3717 1.93e-66 225.0 COG1554@1|root,COG1554@2|Bacteria,46U1D@74201|Verrucomicrobia 74201|Verrucomicrobia G hydrolase, family 65, central catalytic - - - - - - - - - - - - - k59_202511_1 1229909.NSED_08250 8.11e-98 291.0 COG0338@1|root,arCOG03416@2157|Archaea,41SHH@651137|Thaumarchaeota 651137|Thaumarchaeota L PFAM D12 class N6 adenine-specific DNA methyltransferase - - 2.1.1.72 ko:K06223 ko03430,map03430 - - - ko00000,ko00001,ko01000,ko02048,ko03032,ko03400 - - - MethyltransfD12 k59_1442956_1 1168065.DOK_15669 1.51e-65 227.0 COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,1RMQ4@1236|Gammaproteobacteria,1J54P@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria IQ COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II - - 6.2.1.3 ko:K01897,ko:K18661 ko00061,ko00071,ko00280,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map00280,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280,R03383 RC00004,RC00014,RC00137 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding,AMP-binding_C,Acyltransferase,PP-binding,Thioesterase k59_883288_1 1229909.NSED_03765 1.53e-27 110.0 arCOG08764@1|root,arCOG08798@2157|Archaea,41SZ3@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_202513_2 1242864.D187_004592 5.55e-29 112.0 COG2021@1|root,COG2021@2|Bacteria,1QIH6@1224|Proteobacteria 1224|Proteobacteria E Alpha beta hydrolase - - - - - - - - - - - - Abhydrolase_1 k59_1670154_1 1121939.L861_22045 2.08e-62 204.0 COG2201@1|root,COG2201@2|Bacteria,1MWCN@1224|Proteobacteria,1RN67@1236|Gammaproteobacteria,1XI3D@135619|Oceanospirillales 135619|Oceanospirillales NT catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR - - 3.1.1.61,3.5.1.44 ko:K03412 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko02022,ko02035 - - - CheB_methylest,Response_reg k59_1504574_1 631362.Thi970DRAFT_04688 5.85e-72 228.0 COG0407@1|root,COG0407@2|Bacteria,1MUG1@1224|Proteobacteria,1RMDH@1236|Gammaproteobacteria,1WWT0@135613|Chromatiales 135613|Chromatiales H Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III hemE - 4.1.1.37 ko:K01599 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R03197,R04972 RC00872 ko00000,ko00001,ko00002,ko01000 - - - URO-D k59_1615392_1 1344012.ATMI01000056_gene1767 1.71e-07 51.6 COG2890@1|root,COG2890@2|Bacteria,1MX8Q@1224|Proteobacteria,1RPHQ@1236|Gammaproteobacteria,4BTX9@82986|Tatumella 1236|Gammaproteobacteria J Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue prmB GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006304,GO:0006305,GO:0006306,GO:0006464,GO:0006479,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008213,GO:0008276,GO:0008757,GO:0009007,GO:0009008,GO:0009987,GO:0016740,GO:0016741,GO:0018364,GO:0019538,GO:0032259,GO:0032775,GO:0034641,GO:0036009,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0044728,GO:0046483,GO:0071704,GO:0090304,GO:0140096,GO:0140097,GO:1901360,GO:1901564 2.1.1.298 ko:K07320 - - R10806 RC00003,RC03279 ko00000,ko01000,ko03009 - - - MTS k59_1615392_2 232346.JHQL01000001_gene2788 7.34e-71 223.0 COG0082@1|root,COG0082@2|Bacteria,1MU98@1224|Proteobacteria,1RMQS@1236|Gammaproteobacteria,1XHJ7@135619|Oceanospirillales 135619|Oceanospirillales E Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system aroC - 4.2.3.5 ko:K01736 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R01714 RC00586 ko00000,ko00001,ko00002,ko01000 - - - Chorismate_synt k59_482231_1 1454004.AW11_02021 1.8e-58 192.0 COG0668@1|root,COG0668@2|Bacteria,1MY0I@1224|Proteobacteria,2VKTC@28216|Betaproteobacteria 28216|Betaproteobacteria M mechanosensitive ion channel - - - ko:K22044 - - - - ko00000,ko02000 1.A.23.3 - - MS_channel k59_537380_1 1380600.AUYN01000007_gene3256 3.9e-150 439.0 COG3088@1|root,COG3088@2|Bacteria,4NGHU@976|Bacteroidetes,1HY3G@117743|Flavobacteriia 976|Bacteroidetes O Psort location CytoplasmicMembrane, score - - - - - - - - - - - - - k59_91264_1 977880.RALTA_A2349 4.08e-60 194.0 COG1968@1|root,COG1968@2|Bacteria,1MX02@1224|Proteobacteria,2VHSA@28216|Betaproteobacteria,1K33P@119060|Burkholderiaceae 28216|Betaproteobacteria V Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin uppP - 3.6.1.27 ko:K06153 ko00550,map00550 - R05627 RC00002 ko00000,ko00001,ko01000,ko01011 - - - BacA k59_1330074_1 1089553.Tph_c10820 4.73e-26 112.0 COG1766@1|root,COG1766@2|Bacteria,1TRK0@1239|Firmicutes,2498Q@186801|Clostridia,42FQM@68295|Thermoanaerobacterales 186801|Clostridia N The M ring may be actively involved in energy transduction fliF - - ko:K02409 ko02040,map02040 - - - ko00000,ko00001,ko02035,ko02044 3.A.6.2,3.A.6.3 - - YscJ_FliF,YscJ_FliF_C k59_990223_1 323848.Nmul_A2683 3.49e-41 154.0 COG4232@1|root,COG4232@2|Bacteria,1MU8W@1224|Proteobacteria,2VI8I@28216|Betaproteobacteria,371ZZ@32003|Nitrosomonadales 28216|Betaproteobacteria CO Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps dsbD - 1.8.1.8 ko:K04084 - - - - ko00000,ko01000,ko03110 5.A.1.1 - - DsbC,DsbD,Thioredoxin_2,Thioredoxin_7 k59_599770_1 865938.Weevi_1655 7.68e-32 120.0 COG0861@1|root,COG0861@2|Bacteria,4NFFD@976|Bacteroidetes,1HXRT@117743|Flavobacteriia 976|Bacteroidetes P membrane protein TerC terC - - - - - - - - - - - TerC k59_202549_1 1004785.AMBLS11_11620 2.72e-20 87.8 COG1024@1|root,COG1024@2|Bacteria,1PJ4R@1224|Proteobacteria,1RPGI@1236|Gammaproteobacteria,465M2@72275|Alteromonadaceae 1236|Gammaproteobacteria I enoyl-CoA hydratase isomerase - - 4.2.1.17 ko:K01692 ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212 M00032,M00087 R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093 RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 - - - ECH_1 k59_202549_2 953739.SVEN_2995 2.63e-28 117.0 COG1680@1|root,COG1680@2|Bacteria,2GJJB@201174|Actinobacteria 201174|Actinobacteria V COG1680 Beta-lactamase class C and other penicillin binding proteins - - - - - - - - - - - - Beta-lactamase k59_1670180_1 1229909.NSED_08685 1.14e-79 246.0 COG0704@1|root,arCOG00318@2157|Archaea,41SC5@651137|Thaumarchaeota 651137|Thaumarchaeota K Phosphate uptake regulator - - - - - - - - - - - - MazE_antitoxin,PhoU k59_1561858_1 1122194.AUHU01000003_gene2327 1.53e-48 177.0 COG1629@1|root,COG1629@2|Bacteria,COG4771@2|Bacteria,1MV8W@1224|Proteobacteria,1RMQA@1236|Gammaproteobacteria,46619@72275|Alteromonadaceae 1236|Gammaproteobacteria P COG1629 Outer membrane receptor proteins, mostly Fe transport - - - - - - - - - - - - Plug,TonB_dep_Rec k59_712885_1 1122137.AQXF01000001_gene3087 1.8e-283 783.0 COG0029@1|root,COG0029@2|Bacteria,1RBQW@1224|Proteobacteria,2TS0E@28211|Alphaproteobacteria 28211|Alphaproteobacteria H Catalyzes the oxidation of L-aspartate to iminoaspartate nadB - 1.4.3.16 ko:K00278 ko00250,ko00760,ko01100,map00250,map00760,map01100 M00115 R00357,R00481 RC00006,RC02566 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,Succ_DH_flav_C k59_712885_2 1122137.AQXF01000001_gene3088 4.21e-176 498.0 COG1131@1|root,COG1131@2|Bacteria,1MUW7@1224|Proteobacteria,2TR2Q@28211|Alphaproteobacteria 28211|Alphaproteobacteria V ABC transporter yadG - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_145623_1 1197477.IA57_00410 1.25e-32 132.0 COG0739@1|root,COG4733@1|root,COG0739@2|Bacteria,COG4733@2|Bacteria,4PPTH@976|Bacteroidetes,1IKT6@117743|Flavobacteriia 976|Bacteroidetes M heme binding - - - - - - - - - - - - - k59_1780365_1 1163409.UUA_05757 7.07e-69 228.0 COG1200@1|root,COG1200@2|Bacteria,1MWN2@1224|Proteobacteria,1RMMQ@1236|Gammaproteobacteria,1X42Y@135614|Xanthomonadales 135614|Xanthomonadales L Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) recG - 3.6.4.12 ko:K03655 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,HHH_5,Helicase_C,RecG_wedge k59_1227917_1 1122137.AQXF01000002_gene100 3.09e-125 369.0 COG0174@1|root,COG0174@2|Bacteria,1MUGQ@1224|Proteobacteria,2TSCR@28211|Alphaproteobacteria 28211|Alphaproteobacteria E glutamine synthetase glnA - 6.3.1.2 ko:K01915 ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 - R00253 RC00010,RC02798 ko00000,ko00001,ko01000,ko04147 - - - Gln-synt_C,Gln-synt_N k59_1172026_1 203122.Sde_0950 3.37e-85 258.0 COG3717@1|root,COG3717@2|Bacteria,1MU9D@1224|Proteobacteria,1RPDB@1236|Gammaproteobacteria,465F3@72275|Alteromonadaceae 1236|Gammaproteobacteria G Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate kduI - 5.3.1.17 ko:K01815 ko00040,map00040 - R04383 RC00541 ko00000,ko00001,ko01000 - - - KduI k59_1112992_1 1278309.KB907106_gene1355 1.38e-66 216.0 COG0536@1|root,COG0536@2|Bacteria,1MUGZ@1224|Proteobacteria,1RMFQ@1236|Gammaproteobacteria,1XI2X@135619|Oceanospirillales 135619|Oceanospirillales S An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control obgE - - ko:K03979 - - - - ko00000,ko01000,ko03009 - - - GTP1_OBG,MMR_HSR1 k59_1281701_1 1122137.AQXF01000003_gene1943 1.28e-113 340.0 COG3250@1|root,COG3250@2|Bacteria,1R5U9@1224|Proteobacteria,2U3BA@28211|Alphaproteobacteria 28211|Alphaproteobacteria G Vitamin K-dependent gamma-carboxylase - - - - - - - - - - - - VKG_Carbox k59_1172030_1 1379701.JPJC01000014_gene207 1.18e-77 248.0 COG3203@1|root,COG3203@2|Bacteria,1MX4Q@1224|Proteobacteria,2TUSU@28211|Alphaproteobacteria,2K1P5@204457|Sphingomonadales 204457|Sphingomonadales M Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane - - - - - - - - - - - - Porin_2 k59_1172030_2 702113.PP1Y_AT25799 3.36e-92 285.0 COG0477@1|root,COG0477@2|Bacteria,1MU46@1224|Proteobacteria,2TRAP@28211|Alphaproteobacteria,2K0IY@204457|Sphingomonadales 204457|Sphingomonadales EGP Major Facilitator - - - - - - - - - - - - Sugar_tr k59_1570847_1 1242864.D187_010367 3.5e-56 193.0 COG3349@1|root,COG3349@2|Bacteria,1RAVN@1224|Proteobacteria,433WH@68525|delta/epsilon subdivisions,2X3VQ@28221|Deltaproteobacteria,2YX9K@29|Myxococcales 28221|Deltaproteobacteria Q FAD dependent oxidoreductase - - - ko:K09879 ko00906,map00906 - R07541,R07560,R07857,R07858 RC01901,RC01965 ko00000,ko00001 - - - Amino_oxidase k59_1172033_1 1122137.AQXF01000002_gene270 1.1e-47 165.0 COG2234@1|root,COG2234@2|Bacteria,1MWBX@1224|Proteobacteria,2U2RE@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Peptidase M28 - - - - - - - - - - - - Peptidase_M28 k59_1338217_1 634497.HAH_4444 8.15e-29 119.0 COG0474@1|root,arCOG01578@2157|Archaea,2XT4B@28890|Euryarchaeota,23SFC@183963|Halobacteria 183963|Halobacteria P Cation transporting ATPase, C-terminus - - - - - - - - - - - - Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase k59_43730_1 436308.Nmar_0713 1.3e-79 239.0 arCOG10536@1|root,arCOG10536@2157|Archaea 2157|Archaea S Polyketide cyclase / dehydrase and lipid transport - - - - - - - - - - - - Polyketide_cyc2 k59_99671_1 675635.Psed_0385 4.13e-82 263.0 COG1032@1|root,COG1032@2|Bacteria 2|Bacteria C radical SAM domain protein - - - - - - - - - - - - B12-binding,Radical_SAM k59_1400767_2 1459636.NTE_00352 3.16e-15 82.8 COG0464@1|root,arCOG01308@2157|Archaea,41SX8@651137|Thaumarchaeota 651137|Thaumarchaeota O Cell division protein 48 (CDC48), domain 2 - - - ko:K13525 ko04141,ko05134,map04141,map05134 M00400,M00403 - - ko00000,ko00001,ko00002,ko03019,ko04131,ko04147 3.A.16.1 - - AAA,CDC48_2,CDC48_N k59_608804_1 1347342.BN863_17330 3.43e-81 259.0 COG3975@1|root,COG3975@2|Bacteria,4NE4D@976|Bacteroidetes,1HXD0@117743|Flavobacteriia 976|Bacteroidetes S Peptidase, M61 - - - - - - - - - - - - PDZ_2,Peptidase_M61 k59_1623427_2 1122137.AQXF01000002_gene234 3.8e-104 309.0 COG3577@1|root,COG3577@2|Bacteria,1MZCI@1224|Proteobacteria,2U9K2@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Aspartyl protease - - - ko:K06985 ko04112,map04112 - - - ko00000,ko00001 - - - gag-asp_proteas k59_1623427_3 1122137.AQXF01000002_gene235 2.12e-17 79.0 COG1235@1|root,COG1235@2|Bacteria,1MVJH@1224|Proteobacteria,2TQQN@28211|Alphaproteobacteria 28211|Alphaproteobacteria S COG1235 Metal-dependent hydrolases of the beta-lactamase superfamily I phnP - 3.1.4.55 ko:K06167 ko00440,map00440 - R10205 RC00296 ko00000,ko00001,ko01000 - - - Lactamase_B_2 k59_1514464_1 671143.DAMO_1653 3.47e-77 268.0 COG4775@1|root,COG4775@2|Bacteria,2NNNW@2323|unclassified Bacteria 2|Bacteria M Surface antigen bamA GO:0005575,GO:0005623,GO:0008104,GO:0008150,GO:0009279,GO:0009987,GO:0016020,GO:0016043,GO:0019867,GO:0022607,GO:0030312,GO:0030313,GO:0031224,GO:0031230,GO:0031241,GO:0031246,GO:0031975,GO:0032991,GO:0033036,GO:0034613,GO:0043163,GO:0043165,GO:0044085,GO:0044091,GO:0044425,GO:0044462,GO:0044464,GO:0045184,GO:0045229,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0061024,GO:0070727,GO:0071709,GO:0071840,GO:0071944,GO:0072657,GO:0090150,GO:0098552,GO:0098796,GO:1990063 - ko:K07277 - - - - ko00000,ko02000,ko03029 1.B.33 - - Bac_surface_Ag,POTRA k59_893279_1 1122137.AQXF01000002_gene424 4.78e-58 187.0 COG1309@1|root,COG1309@2|Bacteria,1R6X5@1224|Proteobacteria,2U7EK@28211|Alphaproteobacteria 28211|Alphaproteobacteria K transcriptional regulator - - - - - - - - - - - - TetR_N k59_723272_1 1392490.JHZX01000001_gene1131 1.71e-96 295.0 COG2304@1|root,COG2304@2|Bacteria,4NFNQ@976|Bacteroidetes,1I0RD@117743|Flavobacteriia 976|Bacteroidetes S Von Willebrand factor A - - - - - - - - - - - - M64_N,Peptidase_M64 k59_1228821_1 671143.DAMO_1720 1.91e-21 99.0 COG0745@1|root,COG5000@1|root,COG0745@2|Bacteria,COG5000@2|Bacteria 2|Bacteria T phosphorelay sensor kinase activity - - - - - - - - - - - - HAMP,HATPase_c,HisKA,MASE4,PAS,PAS_3,PAS_4,PAS_9,Response_reg,dCache_1,dCache_2 k59_1679530_1 1229909.NSED_06130 3.46e-104 318.0 COG1028@1|root,arCOG01259@2157|Archaea,41S7V@651137|Thaumarchaeota 651137|Thaumarchaeota I Enoyl-(Acyl carrier protein) reductase - - - - - - - - - - - - adh_short k59_1679530_2 1229909.NSED_06125 1.32e-26 98.6 arCOG08727@1|root,arCOG08727@2157|Archaea,41T57@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1624488_1 642492.Clole_2130 3.06e-22 96.3 COG0484@1|root,COG0484@2|Bacteria,1TP00@1239|Firmicutes,248EM@186801|Clostridia 186801|Clostridia O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins dnaJ - - ko:K03686 - - - - ko00000,ko03029,ko03110 - - - DnaJ,DnaJ_C,DnaJ_CXXCXGXG k59_44709_1 443143.GM18_2057 3.13e-17 85.1 COG0683@1|root,COG0683@2|Bacteria,1MXR4@1224|Proteobacteria,42MXX@68525|delta/epsilon subdivisions,2WKJM@28221|Deltaproteobacteria 28221|Deltaproteobacteria E PFAM Extracellular ligand-binding receptor livK-1 - - ko:K01999 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - iAF987.Gmet_1823 Peripla_BP_6 k59_1061291_2 1396418.BATQ01000175_gene2790 7.34e-08 57.0 COG0354@1|root,COG0354@2|Bacteria,46T24@74201|Verrucomicrobia,2IUNG@203494|Verrucomicrobiae 203494|Verrucomicrobiae S Glycine cleavage T-protein C-terminal barrel domain - - - - - - - - - - - - GCV_T,GCV_T_C k59_944263_1 1137799.GZ78_02265 1.51e-100 300.0 COG0479@1|root,COG0479@2|Bacteria,1MVHS@1224|Proteobacteria,1RNWR@1236|Gammaproteobacteria,1XI5Y@135619|Oceanospirillales 135619|Oceanospirillales C Part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration - - 1.3.5.4 ko:K00245 ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020 M00009,M00011,M00150,M00173 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 - - - Fer2_3,Fer4_8 k59_1514503_1 384765.SIAM614_02596 1.14e-75 243.0 COG3653@1|root,COG3653@2|Bacteria,1MWWY@1224|Proteobacteria,2TT5E@28211|Alphaproteobacteria 28211|Alphaproteobacteria Q COG3653 N-acyl-D-aspartate D-glutamate deacylase - - - - - - - - - - - - Amidohydro_3 k59_1282878_1 1415755.JQLV01000001_gene1786 3.64e-61 206.0 COG2918@1|root,COG2918@2|Bacteria,1MW9B@1224|Proteobacteria,1RPNQ@1236|Gammaproteobacteria,1XI43@135619|Oceanospirillales 135619|Oceanospirillales H Belongs to the glutamate--cysteine ligase type 1 family. Type 1 subfamily gshA - 6.3.2.2 ko:K01919 ko00270,ko00480,ko01100,map00270,map00480,map01100 M00118 R00894,R10993 RC00064,RC00090 ko00000,ko00001,ko00002,ko01000 - - - Glu_cys_ligase k59_1061311_1 395493.BegalDRAFT_1808 1.09e-29 122.0 COG0642@1|root,COG5002@1|root,COG0642@2|Bacteria,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,1RQ6G@1236|Gammaproteobacteria 1236|Gammaproteobacteria T Histidine kinase - - - - - - - - - - - - CHASE3,HATPase_c,HisKA,PAS,PAS_9,Response_reg k59_1571842_1 95619.PM1_0204780 1.39e-86 266.0 COG1162@1|root,COG1162@2|Bacteria,1MUEF@1224|Proteobacteria,1RMMB@1236|Gammaproteobacteria 1236|Gammaproteobacteria S One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit rsgA GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019003,GO:0022613,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0036094,GO:0042254,GO:0042274,GO:0043167,GO:0043168,GO:0044085,GO:0044424,GO:0044444,GO:0044464,GO:0071840,GO:0097159,GO:0097367,GO:1901265,GO:1901363 3.1.3.100 ko:K06949 ko00730,ko01100,map00730,map01100 - R00615,R02135 RC00002,RC00017 ko00000,ko00001,ko01000,ko03009 - - iAF1260.b4161,iBWG_1329.BWG_3876,iECDH10B_1368.ECDH10B_4356,iECDH1ME8569_1439.ECDH1ME8569_4021,iEKO11_1354.EKO11_4148,iEcDH1_1363.EcDH1_3829,iEcolC_1368.EcolC_3849,iJO1366.b4161,iUMNK88_1353.UMNK88_5099,iY75_1357.Y75_RS21675 RsgA_GTPase k59_1282885_1 1122137.AQXF01000003_gene2378 6.48e-52 171.0 COG1182@1|root,COG1182@2|Bacteria,1P59R@1224|Proteobacteria,2U63R@28211|Alphaproteobacteria 28211|Alphaproteobacteria I Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity azoR - - ko:K01118 - - - - ko00000,ko01000 - - - Flavodoxin_2 k59_436046_1 565045.NOR51B_2632 1.18e-143 422.0 COG0591@1|root,COG0591@2|Bacteria,1R4VK@1224|Proteobacteria,1RQFS@1236|Gammaproteobacteria,1JBZB@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family nanT - - ko:K03307 - - - - ko00000 2.A.21 - - SSF k59_270166_1 316407.85676598 1.6e-122 348.0 COG1662@1|root,COG1662@2|Bacteria,1RF0C@1224|Proteobacteria,1S5S1@1236|Gammaproteobacteria,3XQAS@561|Escherichia 1236|Gammaproteobacteria L hmm pf03400 - - - ko:K07480 - - - - ko00000 - - - DDE_Tnp_IS1 k59_1789497_1 864069.MicloDRAFT_00005470 8e-150 430.0 COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,2TQTP@28211|Alphaproteobacteria,1JT7T@119045|Methylobacteriaceae 28211|Alphaproteobacteria L transposase IS116 IS110 IS902 family - - - ko:K07486 - - - - ko00000 - - - DEDD_Tnp_IS110,Transposase_20 k59_436055_1 1255043.TVNIR_0417 4.85e-68 211.0 COG0242@1|root,COG0242@2|Bacteria,1RA2P@1224|Proteobacteria,1S247@1236|Gammaproteobacteria,1WXF4@135613|Chromatiales 135613|Chromatiales J Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions def - 3.5.1.88 ko:K01462 - - - - ko00000,ko01000 - - - Pep_deformylase k59_609978_1 935866.JAER01000006_gene3405 3.77e-39 135.0 2AT35@1|root,31IJ7@2|Bacteria,2GQSD@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - - k59_436058_1 349124.Hhal_1056 3.28e-17 81.3 COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,1MU7B@1224|Proteobacteria,1RN2W@1236|Gammaproteobacteria,1WWAR@135613|Chromatiales 135613|Chromatiales E glutamate synthase - - 1.4.1.13,1.4.1.14 ko:K00265 ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 - R00093,R00114,R00248 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - GATase_2,GXGXG,Glu_syn_central,Glu_synthase k59_436058_2 314278.NB231_12294 8.46e-85 263.0 COG0493@1|root,COG0493@2|Bacteria,1MU2H@1224|Proteobacteria,1RMY7@1236|Gammaproteobacteria,1WXP7@135613|Chromatiales 135613|Chromatiales C Pyridine nucleotide-disulphide oxidoreductase - - 1.4.1.13,1.4.1.14 ko:K00266 ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 - R00093,R00114,R00248 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - Fer4_20,Pyr_redox_2 k59_1061329_2 1306406.ASHX01000001_gene1697 0.000584 43.5 COG2268@1|root,COG2268@2|Bacteria,2GKB2@201174|Actinobacteria 201174|Actinobacteria S Band 7 protein - - - - - - - - - - - - Band_7 k59_1789502_1 1122137.AQXF01000006_gene961 1.17e-75 229.0 COG0097@1|root,COG0097@2|Bacteria,1R9YZ@1224|Proteobacteria,2TV09@28211|Alphaproteobacteria 28211|Alphaproteobacteria J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center rplF GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02933 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L6 k59_1789502_2 1122137.AQXF01000006_gene962 4.25e-83 246.0 COG0096@1|root,COG0096@2|Bacteria,1RDG3@1224|Proteobacteria,2U6ZH@28211|Alphaproteobacteria 28211|Alphaproteobacteria J One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit rpsH GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - ko:K02994 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S8 k59_1624538_1 1313421.JHBV01000009_gene4132 2.4e-40 148.0 2DBBI@1|root,2Z888@2|Bacteria,4NQB6@976|Bacteroidetes 976|Bacteroidetes S YHYH protein - - - - - - - - - - - - YHYH k59_832857_1 626887.J057_08786 1.44e-81 274.0 COG0643@1|root,COG0784@1|root,COG2198@1|root,COG0643@2|Bacteria,COG0784@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,1RMS6@1236|Gammaproteobacteria,4650G@72275|Alteromonadaceae 1236|Gammaproteobacteria T COG0643 Chemotaxis protein histidine kinase and related kinases chpA - - ko:K02487,ko:K06596 ko02020,ko02025,map02020,map02025 M00507 - - ko00000,ko00001,ko00002,ko01001,ko02022,ko02035 - - - CheW,H-kinase_dim,HATPase_c,Hpt,Response_reg k59_1571859_2 713587.THITH_09190 2.4e-33 120.0 COG0071@1|root,COG0071@2|Bacteria,1N7C7@1224|Proteobacteria,1S9S6@1236|Gammaproteobacteria,1WY94@135613|Chromatiales 135613|Chromatiales O Belongs to the small heat shock protein (HSP20) family - - - ko:K13993 ko04141,map04141 - - - ko00000,ko00001,ko03110 - - - HSP20 k59_832865_1 713586.KB900536_gene979 1.85e-106 321.0 COG1921@1|root,COG1921@2|Bacteria,1MWXI@1224|Proteobacteria,1RN73@1236|Gammaproteobacteria 1236|Gammaproteobacteria J Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis selA GO:0003674,GO:0003824,GO:0004125,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009059,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016070,GO:0016259,GO:0016260,GO:0016740,GO:0016785,GO:0018130,GO:0019438,GO:0019752,GO:0019842,GO:0030170,GO:0032774,GO:0034641,GO:0034654,GO:0034660,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0090304,GO:0097056,GO:0097159,GO:0140098,GO:0140101,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.9.1.1 ko:K01042 ko00450,ko00970,map00450,map00970 - R08219 RC01246 ko00000,ko00001,ko01000 - - iECP_1309.ECP_3693,iSbBS512_1146.SbBS512_E4006 Se-cys_synth_N,SelA k59_662353_1 69042.WH5701_09920 1.57e-97 293.0 COG3335@1|root,COG3335@2|Bacteria,1G60T@1117|Cyanobacteria,1H3RV@1129|Synechococcus 1117|Cyanobacteria L COG3335 Transposase and inactivated derivatives - - - - - - - - - - - - DDE_3,HTH_23 k59_609985_2 693986.MOC_4956 6.83e-28 112.0 COG2304@1|root,COG2304@2|Bacteria,1MXQ7@1224|Proteobacteria,2TUPX@28211|Alphaproteobacteria,1JSJV@119045|Methylobacteriaceae 28211|Alphaproteobacteria S PFAM von Willebrand factor type A - - - ko:K07114 - - - - ko00000,ko02000 1.A.13.2.2,1.A.13.2.3 - - VWA k59_609986_1 443218.AS9A_4167 1.19e-40 153.0 COG0714@1|root,COG0714@2|Bacteria,2GNQ8@201174|Actinobacteria 201174|Actinobacteria K ATPase involved in DNA repair - - - - - - - - - - - - AAA,AAA_5,DUF3686 k59_1452772_1 685035.ADAE01000018_gene587 6.08e-26 105.0 COG3618@1|root,COG3618@2|Bacteria,1MVG0@1224|Proteobacteria,2TRU9@28211|Alphaproteobacteria,2KD7H@204457|Sphingomonadales 204457|Sphingomonadales S amidohydrolase - - - - - - - - - - - - Amidohydro_2 k59_1452772_2 999550.KI421507_gene422 6.51e-28 115.0 COG1574@1|root,COG1574@2|Bacteria,1MWP2@1224|Proteobacteria,2TXAW@28211|Alphaproteobacteria 28211|Alphaproteobacteria S metal-dependent hydrolase with the TIM-barrel fold - - - - - - - - - - - - Amidohydro_3 k59_1679611_1 1131266.ARWQ01000012_gene1623 2.78e-47 163.0 COG0036@1|root,COG3959@1|root,arCOG01053@2157|Archaea,arCOG05046@2157|Archaea,41SBE@651137|Thaumarchaeota 651137|Thaumarchaeota G Transketolase, thiamine diphosphate binding domain - - 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 - - - Ribul_P_3_epim,Transketolase_N k59_1114065_1 305900.GV64_19065 6.75e-134 385.0 COG0037@1|root,COG0037@2|Bacteria,1MW5Q@1224|Proteobacteria,1RN2H@1236|Gammaproteobacteria,1XIBX@135619|Oceanospirillales 135619|Oceanospirillales J Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32). The sulfur atoms are provided by the cysteine cysteine desulfurase (IscS) system ttcA - - ko:K14058 - - - - ko00000,ko03016 - - - ATP_bind_3 k59_270210_1 436308.Nmar_1718 1.44e-33 124.0 COG1829@1|root,arCOG04263@2157|Archaea,41T1V@651137|Thaumarchaeota 651137|Thaumarchaeota S kinase, sugar kinase superfamily - - 2.7.1.169 ko:K06982 ko00770,ko01100,map00770,map01100 - R09378 RC00002,RC00017 ko00000,ko00001,ko01000 - - - GHMP_kinases_N k59_270210_2 436308.Nmar_1717 4.4e-85 259.0 COG0704@1|root,arCOG00318@2157|Archaea,41T1H@651137|Thaumarchaeota 651137|Thaumarchaeota P Phosphate uptake regulator - - - - - - - - - - - - PhoU k59_1173020_2 314345.SPV1_03033 8.02e-98 293.0 COG1432@1|root,COG1432@2|Bacteria,1MX5C@1224|Proteobacteria 1224|Proteobacteria T OST-HTH/LOTUS domain - - - - - - - - - - - - NYN,OST-HTH k59_491825_1 446468.Ndas_1071 8.5e-105 324.0 COG4264@1|root,COG4264@2|Bacteria,2GMS0@201174|Actinobacteria,4EHC6@85012|Streptosporangiales 201174|Actinobacteria Q IucA / IucC family alcC - - - - - - - - - - - Acetyltransf_8,FhuF,IucA_IucC k59_155328_1 1122137.AQXF01000004_gene1786 2.82e-35 134.0 COG1530@1|root,COG1530@2|Bacteria,1MWBR@1224|Proteobacteria,2TU44@28211|Alphaproteobacteria 28211|Alphaproteobacteria J COG1530 Ribonucleases G and E rng - 3.1.26.12 ko:K08300,ko:K08301 ko03018,map03018 M00394 - - ko00000,ko00001,ko00002,ko01000,ko03009,ko03019 - - - RNase_E_G k59_155328_2 634452.APA01_19930 1.67e-15 70.5 COG3024@1|root,COG3024@2|Bacteria,1NGJ8@1224|Proteobacteria,2UJJF@28211|Alphaproteobacteria,2JUGE@204441|Rhodospirillales 204441|Rhodospirillales S Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase yacG - - ko:K09862 - - - - ko00000 - - - YacG k59_1282969_2 391625.PPSIR1_30539 5e-20 90.1 COG0312@1|root,COG0312@2|Bacteria,1Q3C0@1224|Proteobacteria,4393A@68525|delta/epsilon subdivisions,2X495@28221|Deltaproteobacteria,2YYIX@29|Myxococcales 28221|Deltaproteobacteria S peptidase U62 modulator of DNA gyrase - - - - - - - - - - - - PmbA_TldD k59_270243_1 702113.PP1Y_AT30563 6.9e-117 352.0 COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,1NBSJ@1224|Proteobacteria,2TU21@28211|Alphaproteobacteria,2K2JW@204457|Sphingomonadales 204457|Sphingomonadales C COG1014 Pyruvate ferredoxin oxidoreductase and related 2-oxoacid ferredoxin oxidoreductases, gamma subunit - - 1.2.7.11,1.2.7.3 ko:K00174 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - PFOR_II,POR,POR_N k59_328345_1 298386.PBPRA2525 1.8e-37 141.0 COG0243@1|root,COG1251@1|root,COG0243@2|Bacteria,COG1251@2|Bacteria,1NS3T@1224|Proteobacteria,1RMWN@1236|Gammaproteobacteria,1XUIC@135623|Vibrionales 135623|Vibrionales C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family nasA - - ko:K00372 ko00910,ko01120,map00910,map01120 M00531 R00798,R01106 RC02812 ko00000,ko00001,ko00002,ko01000 - - - Fer2_BFD,Molybdop_Fe4S4,Molybdopterin,Molydop_binding k59_328345_2 566466.NOR53_3021 5.09e-22 93.6 COG2896@1|root,COG2896@2|Bacteria,1MW3W@1224|Proteobacteria,1RR68@1236|Gammaproteobacteria,1J4WP@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate moaA - 4.1.99.22 ko:K03639 ko00790,ko01100,ko04122,map00790,map01100,map04122 - R09394 RC03420 ko00000,ko00001,ko01000 - - - Fer4_12,Mob_synth_C,Radical_SAM k59_1689228_1 592015.HMPREF1705_00172 2.51e-94 303.0 COG0366@1|root,COG3281@1|root,COG0366@2|Bacteria,COG3281@2|Bacteria 2|Bacteria G trehalose biosynthetic process treS GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0005984,GO:0005991,GO:0005992,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009058,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016310,GO:0034637,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044262,GO:0044424,GO:0044444,GO:0044464,GO:0046351,GO:0046835,GO:0071704,GO:0071944,GO:1901576 2.4.1.18,2.7.1.175,3.2.1.1,5.4.99.16 ko:K00700,ko:K05343,ko:K16146 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R01557,R02108,R02110,R02112,R09945,R11262 RC00002,RC00078,RC01816 ko00000,ko00001,ko00002,ko01000,ko04147 - CBM48,GH13 - APH,Alpha-amylase,Malt_amylase_C k59_445391_1 291985.CCSI01000003_gene78 3.38e-64 225.0 COG1629@1|root,COG1629@2|Bacteria,COG4771@2|Bacteria,1MU9K@1224|Proteobacteria,2TS4W@28211|Alphaproteobacteria,2KEEP@204457|Sphingomonadales 204457|Sphingomonadales P COG1629 Outer membrane receptor proteins, mostly Fe transport - - - - - - - - - - - - Plug,TonB_dep_Rec k59_1411386_1 1163617.SCD_n01037 5.84e-82 255.0 COG2956@1|root,COG2956@2|Bacteria,1MVDP@1224|Proteobacteria,2VH49@28216|Betaproteobacteria 28216|Betaproteobacteria G Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane lapB - - ko:K19804 - - - - ko00000 - - - TPR_16,TPR_7 k59_54119_1 1197477.IA57_03120 3.16e-82 272.0 COG1747@1|root,COG1747@2|Bacteria,4NEB8@976|Bacteroidetes,1HXVQ@117743|Flavobacteriia 976|Bacteroidetes S SprA protein sprA - - - - - - - - - - - SprA_N k59_1070350_1 1232683.ADIMK_1279 0.000104 49.3 COG0790@1|root,COG0790@2|Bacteria,1MWPA@1224|Proteobacteria,1RPI3@1236|Gammaproteobacteria,4676I@72275|Alteromonadaceae 1236|Gammaproteobacteria KLT Sel1-like repeats. ybeQ - - ko:K07126 - - - - ko00000 - - - Sel1 k59_902653_1 1248917.ANFX01000012_gene1790 4.43e-25 108.0 COG3827@1|root,COG3827@2|Bacteria,1QQR0@1224|Proteobacteria,2U38X@28211|Alphaproteobacteria,2K2AW@204457|Sphingomonadales 204457|Sphingomonadales - - - - - - - - - - - - - - - k59_902654_1 1121459.AQXE01000006_gene124 6.01e-18 88.2 COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,43AVT@68525|delta/epsilon subdivisions,2X69W@28221|Deltaproteobacteria,2MH0D@213115|Desulfovibrionales 28221|Deltaproteobacteria T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HAMP,HATPase_c,HisKA k59_500506_1 1122137.AQXF01000007_gene3582 9.93e-128 377.0 COG0415@1|root,COG0415@2|Bacteria,1MV9Y@1224|Proteobacteria,2TSDP@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Belongs to the DNA photolyase family phrB GO:0000003,GO:0000166,GO:0000719,GO:0001101,GO:0002252,GO:0002376,GO:0003006,GO:0003674,GO:0003824,GO:0003904,GO:0003913,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005773,GO:0006139,GO:0006259,GO:0006281,GO:0006290,GO:0006325,GO:0006338,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006873,GO:0006874,GO:0006875,GO:0006950,GO:0006952,GO:0006974,GO:0006996,GO:0007154,GO:0007165,GO:0007275,GO:0007623,GO:0008144,GO:0008150,GO:0008152,GO:0009117,GO:0009314,GO:0009414,GO:0009415,GO:0009416,GO:0009605,GO:0009606,GO:0009607,GO:0009615,GO:0009628,GO:0009637,GO:0009638,GO:0009642,GO:0009645,GO:0009646,GO:0009648,GO:0009719,GO:0009725,GO:0009785,GO:0009791,GO:0009881,GO:0009882,GO:0009888,GO:0009893,GO:0009909,GO:0009911,GO:0009987,GO:0010033,GO:0010035,GO:0010073,GO:0010075,GO:0010118,GO:0010228,GO:0010244,GO:0010617,GO:0014070,GO:0016043,GO:0016604,GO:0016829,GO:0016830,GO:0017076,GO:0019222,GO:0019637,GO:0019725,GO:0022414,GO:0022603,GO:0023052,GO:0030003,GO:0030522,GO:0030554,GO:0031323,GO:0031325,GO:0031974,GO:0031981,GO:0032501,GO:0032502,GO:0032553,GO:0032555,GO:0032559,GO:0033554,GO:0033993,GO:0034641,GO:0035639,GO:0036094,GO:0038023,GO:0040008,GO:0042221,GO:0042592,GO:0042726,GO:0042752,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0043207,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0044237,GO:0044238,GO:0044260,GO:0044281,GO:0044422,GO:0044424,GO:0044428,GO:0044444,GO:0044446,GO:0044451,GO:0044464,GO:0046483,GO:0048037,GO:0048507,GO:0048509,GO:0048511,GO:0048518,GO:0048522,GO:0048571,GO:0048573,GO:0048574,GO:0048580,GO:0048582,GO:0048583,GO:0048608,GO:0048638,GO:0048731,GO:0048831,GO:0048856,GO:0048878,GO:0050660,GO:0050662,GO:0050789,GO:0050793,GO:0050794,GO:0050801,GO:0050896,GO:0051094,GO:0051186,GO:0051239,GO:0051240,GO:0051276,GO:0051480,GO:0051607,GO:0051704,GO:0051707,GO:0051716,GO:0055065,GO:0055074,GO:0055080,GO:0055082,GO:0055086,GO:0060089,GO:0061458,GO:0065007,GO:0065008,GO:0070013,GO:0071214,GO:0071478,GO:0071482,GO:0071483,GO:0071704,GO:0071840,GO:0071949,GO:0072387,GO:0072503,GO:0072507,GO:0090304,GO:0097159,GO:0097367,GO:0098542,GO:0098771,GO:0104004,GO:0140097,GO:1900618,GO:1901265,GO:1901360,GO:1901363,GO:1901371,GO:1901564,GO:1901700,GO:1902347,GO:1905421,GO:2000024,GO:2000026,GO:2000028,GO:2000241,GO:2000243,GO:2000377,GO:2000379 4.1.99.3 ko:K01669 - - - - ko00000,ko01000,ko03400 - - - DNA_photolyase,FAD_binding_7 k59_1237796_1 1122614.JHZF01000013_gene3296 7.07e-05 45.1 COG0169@1|root,COG0169@2|Bacteria,1MVH4@1224|Proteobacteria,2TS99@28211|Alphaproteobacteria,2PCZU@252301|Oceanicola 28211|Alphaproteobacteria E Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) aroE - 1.1.1.25 ko:K00014 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02413 RC00206 ko00000,ko00001,ko00002,ko01000 - - - Shikimate_DH,Shikimate_dh_N k59_1237796_2 1205910.B005_2141 4.75e-30 115.0 COG2818@1|root,COG2818@2|Bacteria,2IFH0@201174|Actinobacteria,4EIHG@85012|Streptosporangiales 201174|Actinobacteria L Methyladenine glycosylase - - 3.2.2.20 ko:K01246 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - Adenine_glyco k59_54125_1 640081.Dsui_2537 1.16e-88 279.0 COG3243@1|root,COG3243@2|Bacteria,1MU68@1224|Proteobacteria,2VH50@28216|Betaproteobacteria,2KUWX@206389|Rhodocyclales 206389|Rhodocyclales I Poly(R)-hydroxyalkanoic acid synthase, class I - - - ko:K03821 ko00650,map00650 - R04254 RC00004 ko00000,ko00001,ko01000 - - - PhaC_N k59_953517_1 1535422.ND16A_2985 1.46e-45 158.0 29W19@1|root,30HJP@2|Bacteria,1R60N@1224|Proteobacteria,1S21W@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_1008853_1 29581.BW37_02928 1.07e-48 180.0 COG1014@1|root,COG4231@1|root,COG1014@2|Bacteria,COG4231@2|Bacteria,1MUKS@1224|Proteobacteria,2VJGC@28216|Betaproteobacteria,472TT@75682|Oxalobacteraceae 28216|Betaproteobacteria C Pyruvate ferredoxin/flavodoxin oxidoreductase - - 1.2.7.8 ko:K04090 - - - - br01601,ko00000,ko01000 - - - POR,TPP_enzyme_C k59_1634003_1 215803.DB30_8372 3.99e-28 113.0 COG0845@1|root,COG0845@2|Bacteria,1R50D@1224|Proteobacteria,438S0@68525|delta/epsilon subdivisions,2X3YT@28221|Deltaproteobacteria,2YXMR@29|Myxococcales 28221|Deltaproteobacteria M Biotin-lipoyl like - - - - - - - - - - - - Biotin_lipoyl_2,HlyD_3 k59_953521_1 1280954.HPO_11359 3.45e-70 222.0 COG2175@1|root,COG2175@2|Bacteria,1MV5K@1224|Proteobacteria,2TQTZ@28211|Alphaproteobacteria 28211|Alphaproteobacteria Q taurine catabolism dioxygenase - - 1.14.11.17 ko:K03119 ko00430,ko00920,map00430,map00920 - R05320 RC01331 ko00000,ko00001,ko01000 - - - TauD k59_953521_2 59538.XP_005968778.1 6.39e-51 173.0 COG1062@1|root,KOG0022@2759|Eukaryota,397PJ@33154|Opisthokonta,3BIQH@33208|Metazoa,3CYWE@33213|Bilateria,4871P@7711|Chordata,491PB@7742|Vertebrata,3J1Y5@40674|Mammalia 2759|Eukaryota Q alcohol dehydrogenase (NAD) activity ADH1 GO:0000302,GO:0001101,GO:0001666,GO:0003674,GO:0003824,GO:0004022,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006950,GO:0006970,GO:0006979,GO:0008150,GO:0008152,GO:0009266,GO:0009409,GO:0009410,GO:0009413,GO:0009414,GO:0009415,GO:0009628,GO:0009636,GO:0009651,GO:0009719,GO:0009725,GO:0009737,GO:0009743,GO:0009744,GO:0010033,GO:0010035,GO:0010038,GO:0010243,GO:0014070,GO:0014074,GO:0016020,GO:0016491,GO:0016614,GO:0016616,GO:0031000,GO:0032355,GO:0033993,GO:0034285,GO:0036270,GO:0036293,GO:0042221,GO:0042493,GO:0042542,GO:0042802,GO:0042803,GO:0043279,GO:0044424,GO:0044444,GO:0044464,GO:0046677,GO:0046686,GO:0046983,GO:0048518,GO:0048522,GO:0048583,GO:0048584,GO:0050789,GO:0050794,GO:0050896,GO:0055114,GO:0065007,GO:0070482,GO:0071944,GO:0080134,GO:0080135,GO:0097305,GO:1900037,GO:1900039,GO:1901698,GO:1901700 1.1.1.1,1.1.1.284 ko:K00001,ko:K00121,ko:K02267,ko:K13980,ko:K18857 ko00010,ko00071,ko00190,ko00350,ko00592,ko00625,ko00626,ko00680,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,ko05204,map00010,map00071,map00190,map00350,map00592,map00625,map00626,map00680,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01200,map01220,map04260,map04714,map04932,map05010,map05012,map05016,map05204 M00154 R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R06983,R07105,R08281,R08306,R08310,R10783 RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01715,RC01734,RC02273 ko00000,ko00001,ko00002,ko01000 3.D.4.11,3.D.4.8 - - ADH_N,ADH_zinc_N k59_1689266_1 1248916.ANFY01000008_gene2083 1.8e-09 55.5 COG5481@1|root,COG5481@2|Bacteria,1NG9U@1224|Proteobacteria,2UFXJ@28211|Alphaproteobacteria,2K6XC@204457|Sphingomonadales 204457|Sphingomonadales S Protein of unknown function (DUF465) - - - - - - - - - - - - DUF465 k59_1689266_2 580332.Slit_2248 1.56e-21 89.0 COG1495@1|root,COG1495@2|Bacteria,1RIJE@1224|Proteobacteria,2VREE@28216|Betaproteobacteria,44VV0@713636|Nitrosomonadales 28216|Betaproteobacteria C Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein dsbB - - ko:K03611 - - - - ko00000,ko03110 5.A.2.1 - - DsbB k59_902667_2 387093.SUN_1730 2.33e-29 115.0 2APHP@1|root,31EKP@2|Bacteria,1RKUB@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_902667_3 526222.Desal_2457 1.23e-07 58.9 COG0834@1|root,COG0834@2|Bacteria,1N1QD@1224|Proteobacteria,42V76@68525|delta/epsilon subdivisions,2WRPM@28221|Deltaproteobacteria,2MDZB@213115|Desulfovibrionales 28221|Deltaproteobacteria ET PFAM Extracellular solute-binding protein, family 3 - - - ko:K02030 - M00236 - - ko00000,ko00002,ko02000 3.A.1.3 - - SBP_bac_3 k59_556448_1 768671.ThimaDRAFT_3635 3.79e-33 119.0 2C3ZQ@1|root,32SCF@2|Bacteria,1N27R@1224|Proteobacteria,1S4HC@1236|Gammaproteobacteria,1X16N@135613|Chromatiales 135613|Chromatiales S MEKHLA domain - - - - - - - - - - - - MEKHLA k59_671582_1 279238.Saro_3427 4.81e-88 268.0 COG2514@1|root,COG2514@2|Bacteria,1QURE@1224|Proteobacteria,2TW59@28211|Alphaproteobacteria,2K2KW@204457|Sphingomonadales 204457|Sphingomonadales S Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - - - - - - - - - - Glyoxalase k59_671582_2 1114970.PSF113_0823 2.01e-83 259.0 COG0654@1|root,COG0654@2|Bacteria,1MWWT@1224|Proteobacteria,1RYXJ@1236|Gammaproteobacteria 1236|Gammaproteobacteria CH 2-polyprenyl-6-methoxyphenol hydroxylase - - 1.14.13.182 ko:K17940 ko00405,ko01130,ko02024,ko02025,map00405,map01130,map02024,map02025 - R10467 RC00236 ko00000,ko00001,ko01000 - - - FAD_binding_3 k59_1689268_1 82995.CR62_23465 1.61e-05 50.4 COG0472@1|root,COG0472@2|Bacteria,1MWYW@1224|Proteobacteria,1RNAP@1236|Gammaproteobacteria,4021R@613|Serratia 1236|Gammaproteobacteria M Catalyzes the transfer of the GlcNAc-1-phosphate moiety from UDP-GlcNAc onto the carrier lipid undecaprenyl phosphate (C55-P), yielding GlcNAc-pyrophosphoryl-undecaprenyl (GlcNAc-PP- C55) wecA - 2.7.8.33,2.7.8.35 ko:K02851 - - R08856 RC00002 ko00000,ko01000,ko01003,ko01005 - - - Glycos_transf_4 k59_1070375_1 700598.Niako_6291 3.15e-57 201.0 COG3087@1|root,COG3087@2|Bacteria,4PNV5@976|Bacteroidetes 976|Bacteroidetes D Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides - - - - - - - - - - - - - k59_445428_2 998674.ATTE01000001_gene514 1.98e-07 55.8 COG2165@1|root,COG2165@2|Bacteria 2|Bacteria NU general secretion pathway protein gspH - - ko:K02457,ko:K02650 ko02020,ko03070,ko05111,map02020,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02035,ko02044 3.A.15,3.A.15.2 - - GspH,N_methyl k59_445428_3 1122137.AQXF01000005_gene1353 2.93e-26 100.0 COG2165@1|root,COG2165@2|Bacteria,1RDX2@1224|Proteobacteria,2U8VA@28211|Alphaproteobacteria 28211|Alphaproteobacteria NU general secretion pathway protein G gspG - - ko:K02456 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - N_methyl,T2SSG k59_1798634_1 1122137.AQXF01000003_gene1935 1.28e-92 282.0 COG0263@1|root,COG0263@2|Bacteria,1MUBG@1224|Proteobacteria,2TRKB@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate proB - 2.7.2.11 ko:K00931 ko00330,ko00332,ko01100,ko01130,ko01230,map00330,map00332,map01100,map01130,map01230 M00015 R00239 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase,PUA k59_1008863_1 63737.Npun_R4400 3.93e-25 103.0 COG0475@1|root,COG0475@2|Bacteria,1GC7W@1117|Cyanobacteria,1HIBD@1161|Nostocales 1117|Cyanobacteria P PFAM sodium hydrogen exchanger - - - - - - - - - - - - Na_H_Exchanger k59_1008863_2 1121033.AUCF01000016_gene5551 6.54e-12 65.9 COG0642@1|root,COG0642@2|Bacteria,1MX6R@1224|Proteobacteria,2TS9N@28211|Alphaproteobacteria,2JPH2@204441|Rhodospirillales 204441|Rhodospirillales T Histidine kinase-like ATPases - - - - - - - - - - - - HATPase_c k59_279724_1 690585.JNNU01000004_gene4368 2.15e-12 71.2 COG0679@1|root,COG0679@2|Bacteria,1MY23@1224|Proteobacteria,2TR4M@28211|Alphaproteobacteria,4B7BX@82115|Rhizobiaceae 28211|Alphaproteobacteria S Membrane transport protein - - - ko:K07088 - - - - ko00000 - - - Mem_trans k59_279724_2 109760.SPPG_00553T0 1.9e-19 86.7 2D4HJ@1|root,2SV6U@2759|Eukaryota,39MXR@33154|Opisthokonta 33154|Opisthokonta O Glutathione S-transferase, N-terminal domain - - - - - - - - - - - - GST_N_3 k59_1523708_1 436308.Nmar_1283 5.94e-17 78.6 COG0600@1|root,arCOG00169@2157|Archaea,41SIT@651137|Thaumarchaeota 651137|Thaumarchaeota P ABC-type nitrate sulfonate bicarbonate transport system, permease component - - - ko:K02050 - M00188 - - ko00000,ko00002,ko02000 3.A.1.16,3.A.1.17 - - BPD_transp_1 k59_1523708_2 436308.Nmar_1284 9.29e-75 230.0 COG1116@1|root,arCOG00193@2157|Archaea,41S6Q@651137|Thaumarchaeota 651137|Thaumarchaeota E ABC-type nitrate sulfonate bicarbonate transport system, ATPase component - - - ko:K02049 - M00188 - - ko00000,ko00002,ko02000 3.A.1.16,3.A.1.17 - - ABC_tran k59_1798636_1 330214.NIDE2536 8.25e-115 347.0 COG0021@1|root,COG0021@2|Bacteria,3J0MM@40117|Nitrospirae 40117|Nitrospirae G Transketolase, pyrimidine binding domain - - 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 - - - Transket_pyr,Transketolase_C,Transketolase_N k59_279726_1 436308.Nmar_0097 1.11e-51 174.0 COG0484@1|root,arCOG02846@2157|Archaea,41SCZ@651137|Thaumarchaeota 651137|Thaumarchaeota O DnaJ central domain - - - ko:K03686 - - - - ko00000,ko03029,ko03110 - - - DnaJ,DnaJ_C,DnaJ_CXXCXGXG k59_1634020_1 1235457.C404_19325 2.55e-80 266.0 COG1703@1|root,COG1884@1|root,COG2185@1|root,COG1703@2|Bacteria,COG1884@2|Bacteria,COG2185@2|Bacteria,1MUXX@1224|Proteobacteria,2VH05@28216|Betaproteobacteria,1K4Q5@119060|Burkholderiaceae 28216|Betaproteobacteria EI Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly icmF GO:0000166,GO:0000287,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0006139,GO:0006163,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009117,GO:0009150,GO:0009259,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016866,GO:0017076,GO:0017111,GO:0019001,GO:0019637,GO:0019693,GO:0019842,GO:0031419,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0033865,GO:0033875,GO:0034032,GO:0034641,GO:0034784,GO:0035383,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043603,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0046872,GO:0046906,GO:0047727,GO:0048037,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:0097159,GO:0097367,GO:1901135,GO:1901265,GO:1901360,GO:1901363,GO:1901564 5.4.99.13 ko:K11942 - - - - ko00000,ko01000 - - - ArgK,B12-binding,MM_CoA_mutase k59_1746231_1 1177181.T9A_01587 6.3e-42 142.0 COG2954@1|root,COG2954@2|Bacteria,1RI38@1224|Proteobacteria,1S77V@1236|Gammaproteobacteria,1XMAC@135619|Oceanospirillales 135619|Oceanospirillales S protein conserved in bacteria - - 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 - - - CYTH k59_1746231_2 1237149.C900_01071 8.02e-92 287.0 COG4799@1|root,COG4799@2|Bacteria,4NEMJ@976|Bacteroidetes,47K3E@768503|Cytophagia 976|Bacteroidetes I Acetyl-CoA carboxylase carboxyltransferase component (subunits alpha and beta) pccB - 2.1.3.15,6.4.1.3 ko:K01966 ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200 M00373,M00741 R01859 RC00097,RC00609 ko00000,ko00001,ko00002,ko01000 - - - Carboxyl_trans k59_671621_1 314285.KT71_18426 2.62e-95 293.0 28I8B@1|root,2Z8B5@2|Bacteria,1MUNM@1224|Proteobacteria,1RQ1H@1236|Gammaproteobacteria,1J4H2@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Cytochrome c bacterial - - - - - - - - - - - - Cytochrome_C554,Cytochrome_cB k59_953543_1 1122137.AQXF01000003_gene2156 1.3e-54 176.0 COG0632@1|root,COG0632@2|Bacteria,1MWJR@1224|Proteobacteria,2TSKM@28211|Alphaproteobacteria 28211|Alphaproteobacteria L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB ruvA GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0050896,GO:0051716,GO:0071496 3.6.4.12 ko:K03550 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - HHH_5,RuvA_C,RuvA_N k59_953543_2 1122137.AQXF01000003_gene2155 2.57e-87 259.0 COG0817@1|root,COG0817@2|Bacteria,1MUJI@1224|Proteobacteria,2U70Z@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group ruvC GO:0000725,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0008821,GO:0009058,GO:0009059,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0016787,GO:0016788,GO:0016889,GO:0016894,GO:0031297,GO:0031668,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0045005,GO:0046483,GO:0048476,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0071932,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901576 3.1.22.4 ko:K01159 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - RuvC k59_221668_2 983920.Y88_0640 2e-09 55.1 COG3847@1|root,COG3847@2|Bacteria 2|Bacteria U Flp Fap pilin component - - - ko:K02651 ko04112,map04112 - - - ko00000,ko00001,ko02035,ko02044 - - - Flp_Fap k59_902693_1 1123400.KB904769_gene2806 3.7e-19 90.1 COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,1RME8@1236|Gammaproteobacteria,45ZVM@72273|Thiotrichales 72273|Thiotrichales O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins ftsH - - ko:K03798 - M00742 - - ko00000,ko00002,ko01000,ko01002,ko03110 - - - AAA,FtsH_ext,Peptidase_M41 k59_1292674_1 717772.THIAE_00915 2.97e-134 394.0 COG0715@1|root,COG0715@2|Bacteria,1MWDN@1224|Proteobacteria,1RPUP@1236|Gammaproteobacteria,45ZQ1@72273|Thiotrichales 1236|Gammaproteobacteria P NMT1-like family nrtA - - ko:K15576 ko00910,ko02010,map00910,map02010 M00438 - - ko00000,ko00001,ko00002,ko02000 3.A.1.16.1,3.A.1.16.2 - - NMT1_2 k59_1008891_1 1229909.NSED_00970 1.7e-158 461.0 COG0532@1|root,arCOG01560@2157|Archaea,41SBY@651137|Thaumarchaeota 651137|Thaumarchaeota J Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2 infB - - ko:K03243 ko03013,map03013 - - - ko00000,ko00001,ko03012 - - - GTP_EFTU,GTP_EFTU_D4,IF-2 k59_164533_1 1122137.AQXF01000006_gene780 2.66e-109 330.0 COG0018@1|root,COG0018@2|Bacteria,1MU4J@1224|Proteobacteria,2TS3Y@28211|Alphaproteobacteria 28211|Alphaproteobacteria J Arginyl-tRNA synthetase argS - 6.1.1.19 ko:K01887 ko00970,map00970 M00359,M00360 R03646 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d k59_1746249_1 1415778.JQMM01000001_gene694 2.48e-34 129.0 COG0042@1|root,COG0042@2|Bacteria,1MV5V@1224|Proteobacteria,1RMJP@1236|Gammaproteobacteria,1J4ZK@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines dusB GO:0002943,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009314,GO:0009451,GO:0009628,GO:0009987,GO:0010467,GO:0016070,GO:0016491,GO:0016627,GO:0017150,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0050896,GO:0055114,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 - ko:K05540 - - - - ko00000,ko01000,ko03016 - - - Dus k59_394448_1 931277.C448_06675 2.36e-17 85.9 COG4948@1|root,arCOG01168@2157|Archaea,2XU6X@28890|Euryarchaeota,23SAR@183963|Halobacteria 183963|Halobacteria H Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB) menC - - - - - - - - - - - MR_MLE_C,MR_MLE_N k59_221677_2 880071.Fleli_1691 3.73e-08 61.2 COG0587@1|root,COG0847@1|root,COG1372@1|root,COG0587@2|Bacteria,COG0847@2|Bacteria,COG1372@2|Bacteria,4NFA0@976|Bacteroidetes,47K9H@768503|Cytophagia 976|Bacteroidetes L DNA-directed DNA polymerase dnaE - 2.7.7.7 ko:K02337 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP,RNase_T,tRNA_anti-codon k59_953572_1 105559.Nwat_1142 2.36e-90 290.0 COG2609@1|root,COG2609@2|Bacteria,1MV21@1224|Proteobacteria,1RN6K@1236|Gammaproteobacteria,1WWE0@135613|Chromatiales 135613|Chromatiales C Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) aceE - 1.2.4.1 ko:K00163 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200 M00307 R00014,R00209,R01699,R03270 RC00004,RC00027,RC00627,RC02742,RC02744,RC02882 br01601,ko00000,ko00001,ko00002,ko01000 - - - Transketolase_N k59_445459_1 926549.KI421517_gene16 1.52e-110 340.0 COG2838@1|root,COG2838@2|Bacteria,4NFV1@976|Bacteroidetes,47K8A@768503|Cytophagia 976|Bacteroidetes C Monomeric isocitrate dehydrogenase icd - 1.1.1.42 ko:K00031 ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146 M00009,M00010,M00173,M00740 R00267,R00268,R01899 RC00001,RC00084,RC00114,RC00626,RC02801 br01601,ko00000,ko00001,ko00002,ko01000 - - - IDH k59_1411440_1 561231.Pecwa_3183 2.59e-25 98.2 COG1393@1|root,COG1393@2|Bacteria,1MZ4Z@1224|Proteobacteria,1S8XH@1236|Gammaproteobacteria,1MSP7@122277|Pectobacterium 1236|Gammaproteobacteria C arsenate reductase arsC GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 1.20.4.1 ko:K00537 - - - - ko00000,ko01000 - - - ArsC k59_1292698_1 436308.Nmar_1511 1.28e-141 409.0 COG0172@1|root,arCOG00403@2157|Archaea,41SC9@651137|Thaumarchaeota 651137|Thaumarchaeota J Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) serS - 6.1.1.11 ko:K01875 ko00970,map00970 M00359,M00360 R03662,R08218 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Seryl_tRNA_N,tRNA-synt_2b k59_110199_1 997346.HMPREF9374_2979 5.39e-34 122.0 COG0521@1|root,COG0521@2|Bacteria,1V3XM@1239|Firmicutes,4IBW3@91061|Bacilli,27CY3@186824|Thermoactinomycetaceae 91061|Bacilli H Probable molybdopterin binding domain - - - - - - - - - - - - MoCF_biosynth k59_110199_2 498761.HM1_0062 3.73e-46 154.0 COG2258@1|root,COG2258@2|Bacteria,1V6DS@1239|Firmicutes,24HBA@186801|Clostridia 186801|Clostridia H MOSC domain - - - - - - - - - - - - MOSC,MoCF_biosynth k59_1746269_1 1121127.JAFA01000002_gene1600 6.29e-28 119.0 COG0515@1|root,COG2203@1|root,COG3899@1|root,COG4191@1|root,COG0515@2|Bacteria,COG2203@2|Bacteria,COG3899@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2VICN@28216|Betaproteobacteria,1K3Q3@119060|Burkholderiaceae 28216|Betaproteobacteria T ATP-binding region ATPase domain protein - - - - - - - - - - - - AAA_16,GAF,HATPase_c,HisKA,PAS_9,Pkinase k59_902706_1 1347342.BN863_3380 1.95e-83 252.0 COG0345@1|root,COG0345@2|Bacteria,4NE6F@976|Bacteroidetes,1HX1Q@117743|Flavobacteriia 976|Bacteroidetes E Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline proC - 1.5.1.2 ko:K00286 ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230 M00015 R01248,R01251,R03291,R03293 RC00054,RC00083 ko00000,ko00001,ko00002,ko01000 - - - F420_oxidored,P5CR_dimer k59_902706_2 1121912.AUHD01000003_gene3149 4.66e-80 248.0 COG4992@1|root,COG4992@2|Bacteria,4NE0Z@976|Bacteroidetes,1HXQB@117743|Flavobacteriia 976|Bacteroidetes E Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family argD - 2.6.1.11,2.6.1.17 ko:K00821 ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00028,M00845 R02283,R04475 RC00006,RC00062 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 k59_902712_1 580332.Slit_0725 1.7e-68 214.0 COG0115@1|root,COG0115@2|Bacteria,1MVAT@1224|Proteobacteria,2VIVK@28216|Betaproteobacteria,44WCS@713636|Nitrosomonadales 28216|Betaproteobacteria H PFAM aminotransferase class IV dat - 2.6.1.21 ko:K00824 ko00310,ko00330,ko00360,ko00472,ko00473,ko01100,map00310,map00330,map00360,map00472,map00473,map01100 - R01148,R01582,R02459,R02851,R02924,R05053 RC00006,RC00008,RC00025 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_4 k59_902712_2 580332.Slit_0724 3.36e-07 48.9 COG2921@1|root,COG2921@2|Bacteria,1RGV5@1224|Proteobacteria,2VTY5@28216|Betaproteobacteria,44W1W@713636|Nitrosomonadales 28216|Betaproteobacteria S Protein of unknown function (DUF493) ybeD - - ko:K09158 - - - - ko00000 - - - DUF493 k59_1070422_2 382464.ABSI01000012_gene2217 1.15e-45 166.0 COG2374@1|root,COG2374@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - Big_3_5,LTD k59_337475_1 748658.KB907315_gene2645 0.0 901.0 COG1048@1|root,COG1048@2|Bacteria,1MU9T@1224|Proteobacteria,1RN5I@1236|Gammaproteobacteria,1WW6D@135613|Chromatiales 135613|Chromatiales C Catalyzes the isomerization of citrate to isocitrate via cis-aconitate - - 4.2.1.3 ko:K01681 ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00173,M00740 R01324,R01325,R01900 RC00497,RC00498,RC00618 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase,Aconitase_C k59_337475_2 395495.Lcho_1839 1.62e-08 53.9 COG0271@1|root,COG0271@2|Bacteria,1MZG5@1224|Proteobacteria,2VVNP@28216|Betaproteobacteria,1KMJC@119065|unclassified Burkholderiales 28216|Betaproteobacteria T Belongs to the BolA IbaG family bolA - - ko:K05527 - - - - ko00000,ko03000 - - - BolA k59_556490_1 1453501.JELR01000001_gene2854 5.88e-33 129.0 COG2207@1|root,COG2207@2|Bacteria,1R8G9@1224|Proteobacteria,1RZ2D@1236|Gammaproteobacteria,465XS@72275|Alteromonadaceae 1236|Gammaproteobacteria K helix_turn_helix, arabinose operon control protein - - - - - - - - - - - - HTH_18 k59_164570_2 1245471.PCA10_28240 2.54e-49 167.0 COG4221@1|root,COG4221@2|Bacteria,1MUF8@1224|Proteobacteria,1S79Y@1236|Gammaproteobacteria 1236|Gammaproteobacteria S KR domain - - - - - - - - - - - - adh_short k59_394479_1 1144305.PMI02_04764 1.59e-46 162.0 COG1289@1|root,COG1289@2|Bacteria,1PMRM@1224|Proteobacteria,2U2PT@28211|Alphaproteobacteria,2K31B@204457|Sphingomonadales 204457|Sphingomonadales S Fusaric acid resistance protein family - - - - - - - - - - - - FUSC_2 k59_1123338_1 379731.PST_2465 2.89e-13 74.7 COG1752@1|root,COG4775@1|root,COG1752@2|Bacteria,COG4775@2|Bacteria,1MUM9@1224|Proteobacteria,1RRSK@1236|Gammaproteobacteria,1Z109@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria M esterase of the alpha-beta hydrolase superfamily plpD - - ko:K07001 - - - - ko00000 - - - Bac_surface_Ag,POTRA,Patatin k59_619786_1 1112212.JH584235_gene2946 8.08e-36 135.0 COG2948@1|root,COG2948@2|Bacteria,1MU7U@1224|Proteobacteria,2VEQH@28211|Alphaproteobacteria,2KDT7@204457|Sphingomonadales 204457|Sphingomonadales U Bacterial conjugation TrbI-like protein - - - ko:K20533 ko02024,map02024 - - - ko00000,ko00001,ko02044 3.A.7.4 - - TrbI k59_445477_1 392500.Swoo_0198 5.81e-12 72.0 COG3209@1|root,COG4733@1|root,COG3209@2|Bacteria,COG4733@2|Bacteria,1MVV1@1224|Proteobacteria,1RMPT@1236|Gammaproteobacteria,2QAGA@267890|Shewanellaceae 1236|Gammaproteobacteria M COG3209 Rhs family protein - - - - - - - - - - - - RHS_repeat,SpvB,TcdB_toxin_midN,VCBS k59_164582_1 1415778.JQMM01000001_gene173 1.32e-72 241.0 COG1033@1|root,COG1033@2|Bacteria,1MUE1@1224|Proteobacteria,1RNWM@1236|Gammaproteobacteria,1J4YY@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S exporters of the RND superfamily - - - ko:K07003 - - - - ko00000 - - - MMPL k59_1411496_1 1229909.NSED_02380 1.05e-41 143.0 COG0640@1|root,arCOG01686@2157|Archaea 2157|Archaea K regulatory protein, arsR - - - - - - - - - - - - HTH_20 k59_732816_1 1379270.AUXF01000004_gene3035 4.66e-79 246.0 COG0050@1|root,COG0050@2|Bacteria,1ZSZD@142182|Gemmatimonadetes 142182|Gemmatimonadetes J This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis tuf - - ko:K02358 - - - - ko00000,ko03012,ko03029,ko04147 - - - GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3 k59_1349480_1 247639.MGP2080_12628 8e-06 53.1 COG4774@1|root,COG4774@2|Bacteria,1R6E9@1224|Proteobacteria,1RSF6@1236|Gammaproteobacteria 1236|Gammaproteobacteria P COG1629 Outer membrane receptor proteins, mostly Fe transport - - - - - - - - - - - - Plug,TonB_dep_Rec k59_1799536_1 1197477.IA57_05375 4.28e-100 312.0 COG1629@1|root,COG4771@2|Bacteria,4NF4B@976|Bacteroidetes,1HXF4@117743|Flavobacteriia 976|Bacteroidetes P TonB-dependent receptor - - - - - - - - - - - - CarbopepD_reg_2,Plug,TonB_dep_Rec k59_1799536_2 1380600.AUYN01000007_gene3121 2.13e-21 91.7 28PKM@1|root,2ZCA0@2|Bacteria,4NHEG@976|Bacteroidetes,1I1K5@117743|Flavobacteriia 976|Bacteroidetes S Domain of unknown function (DUF4249) - - - - - - - - - - - - DUF4249 k59_1527789_2 765910.MARPU_12710 6.77e-49 163.0 COG4665@1|root,COG4665@2|Bacteria,1RHBW@1224|Proteobacteria,1S5Y0@1236|Gammaproteobacteria,1WXYX@135613|Chromatiales 135613|Chromatiales Q TRAP-type mannitol chloroaromatic compound transport system, small permease component - - - - - - - - - - - - DctQ k59_1527789_3 1123519.PSJM300_12255 1.83e-06 48.5 COG0168@1|root,COG0168@2|Bacteria,1MUIJ@1224|Proteobacteria,1RMN6@1236|Gammaproteobacteria,1Z0XI@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria P Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA trkH - - ko:K03498 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - - TrkH k59_172119_1 1502850.FG91_00925 3.95e-56 190.0 COG0492@1|root,COG1145@1|root,COG0492@2|Bacteria,COG1145@2|Bacteria,1PR9I@1224|Proteobacteria,2U1SM@28211|Alphaproteobacteria,2K253@204457|Sphingomonadales 204457|Sphingomonadales C 4Fe-4S binding domain - - - - - - - - - - - - Fer4,Fer4_4,Pyr_redox_3 k59_793526_2 983920.Y88_2744 8.11e-54 171.0 COG0375@1|root,COG0375@2|Bacteria,1MZJH@1224|Proteobacteria,2UBR0@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Probably plays a role in a hydrogenase nickel cofactor insertion step hypA - - ko:K04651 - - - - ko00000,ko03110 - - - HypA k59_567600_1 1504672.669786105 1.42e-56 191.0 COG0812@1|root,COG0812@2|Bacteria,1MXDH@1224|Proteobacteria,2VI7I@28216|Betaproteobacteria,4AA6J@80864|Comamonadaceae 28216|Betaproteobacteria M Cell wall formation murB - 1.3.1.98 ko:K00075 ko00520,ko00550,ko01100,map00520,map00550,map01100 - R03191,R03192 RC02639 ko00000,ko00001,ko01000,ko01011 - - - FAD_binding_4,MurB_C k59_115752_1 1123059.KB823012_gene2126 5.3e-81 255.0 COG1972@1|root,COG1972@2|Bacteria,1MXXX@1224|Proteobacteria,2TU8A@28211|Alphaproteobacteria,43WJ9@69657|Hyphomonadaceae 28211|Alphaproteobacteria F nucleoside transporter - - - ko:K03317 - - - - ko00000 2.A.41 - - Gate,Nucleos_tra2_C,Nucleos_tra2_N k59_1640854_1 1499967.BAYZ01000048_gene2702 6.13e-74 229.0 COG3752@1|root,COG3752@2|Bacteria,2NR3R@2323|unclassified Bacteria 2|Bacteria S 3-oxo-5-alpha-steroid 4-dehydrogenase yfhH - 1.3.1.22 ko:K12343 ko00140,map00140 - R02208,R02497,R08954,R10242 RC00145 ko00000,ko00001,ko01000 - - - DUF1295 k59_849881_1 1121430.JMLG01000001_gene2367 9.31e-42 154.0 COG0006@1|root,COG0006@2|Bacteria,1TSXE@1239|Firmicutes,248AF@186801|Clostridia,2604W@186807|Peptococcaceae 186801|Clostridia E PFAM peptidase M24 - - - - - - - - - - - - Creatinase_N,Peptidase_M24 k59_737178_1 1122137.AQXF01000002_gene526 8.55e-49 174.0 COG2172@1|root,COG2199@1|root,COG2208@1|root,COG2172@2|Bacteria,COG2208@2|Bacteria,COG3706@2|Bacteria,1N4K5@1224|Proteobacteria,2TS77@28211|Alphaproteobacteria 28211|Alphaproteobacteria T response regulator - - 3.1.3.3 ko:K07315 - - - - ko00000,ko01000,ko03021 - - - Response_reg,SpoIIE k59_1245476_1 1335757.SPICUR_08245 3.63e-15 70.1 COG0255@1|root,COG0255@2|Bacteria,1N6PR@1224|Proteobacteria,1SCBN@1236|Gammaproteobacteria,1WZ6K@135613|Chromatiales 135613|Chromatiales J Belongs to the universal ribosomal protein uL29 family rpmC - - ko:K02904 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L29 k59_1245476_2 1195246.AGRI_12117 2.56e-33 117.0 COG0186@1|root,COG0186@2|Bacteria,1MZIK@1224|Proteobacteria,1S8SS@1236|Gammaproteobacteria,467RN@72275|Alteromonadaceae 1236|Gammaproteobacteria J One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA rpsQ GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042221,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046677,GO:0050896,GO:0065003,GO:0070181,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02961 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S17 k59_285162_1 160492.XF_0621 1.6e-39 143.0 COG0351@1|root,COG0351@2|Bacteria,1MU9J@1224|Proteobacteria,1RNFP@1236|Gammaproteobacteria,1X38P@135614|Xanthomonadales 135614|Xanthomonadales H Phosphomethylpyrimidine kinase thiD - 2.7.1.49,2.7.4.7 ko:K00941 ko00730,ko01100,map00730,map01100 M00127 R03471,R04509 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - Phos_pyr_kin k59_962839_1 1121434.AULY01000006_gene929 9.08e-39 148.0 COG0668@1|root,COG0668@2|Bacteria,1MXD2@1224|Proteobacteria,43C4Y@68525|delta/epsilon subdivisions,2X7FA@28221|Deltaproteobacteria 28221|Deltaproteobacteria M Mechanosensitive ion channel - - - - - - - - - - - - MS_channel k59_341619_1 316407.85675990 5.53e-115 336.0 COG0530@1|root,COG0530@2|Bacteria,1MU3R@1224|Proteobacteria,1RMRD@1236|Gammaproteobacteria,3XMSD@561|Escherichia 1236|Gammaproteobacteria P calcium:cation antiporter activity yrbG GO:0003674,GO:0005215,GO:0005216,GO:0005261,GO:0005262,GO:0005488,GO:0005509,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0006814,GO:0006816,GO:0006873,GO:0006874,GO:0006875,GO:0008150,GO:0008273,GO:0008324,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015081,GO:0015085,GO:0015267,GO:0015291,GO:0015297,GO:0015298,GO:0015318,GO:0015368,GO:0015491,GO:0015672,GO:0016020,GO:0016021,GO:0019725,GO:0022803,GO:0022804,GO:0022821,GO:0022838,GO:0022857,GO:0022890,GO:0030001,GO:0030003,GO:0030955,GO:0031224,GO:0031226,GO:0031402,GO:0031420,GO:0034220,GO:0035725,GO:0042592,GO:0043167,GO:0043169,GO:0044425,GO:0044459,GO:0044464,GO:0046872,GO:0046873,GO:0048878,GO:0050801,GO:0051179,GO:0051234,GO:0055065,GO:0055074,GO:0055080,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0070588,GO:0070838,GO:0071804,GO:0071805,GO:0071944,GO:0072503,GO:0072507,GO:0072511,GO:0098655,GO:0098660,GO:0098662,GO:0098771,GO:0099516 - ko:K07301 - - - - ko00000,ko02000 2.A.19.5 - iAPECO1_1312.APECO1_3239,iECABU_c1320.ECABU_c36110,iECNA114_1301.ECNA114_3275,iECOK1_1307.ECOK1_3617,iECS88_1305.ECS88_3578,iECSF_1327.ECSF_3028,iUMN146_1321.UM146_00400,iUTI89_1310.UTI89_C3632,ic_1306.c3956 Na_Ca_ex k59_398000_1 498211.CJA_2748 9.23e-67 215.0 COG0151@1|root,COG0151@2|Bacteria,1MUAH@1224|Proteobacteria,1RNS4@1236|Gammaproteobacteria,1FGDA@10|Cellvibrio 1236|Gammaproteobacteria F Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain purD GO:0000166,GO:0003674,GO:0003824,GO:0004637,GO:0005488,GO:0005524,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016874,GO:0016879,GO:0016887,GO:0017076,GO:0017111,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0033554,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0050896,GO:0051716,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.3.2.6,6.3.4.13 ko:K01945,ko:K13713 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04144,R04591 RC00064,RC00090,RC00162,RC00166 ko00000,ko00001,ko00002,ko01000 - - iECNA114_1301.ECNA114_3417,iECSF_1327.ECSF_3859,iJN746.PP_4823,iPC815.YPO3729 GARS_A,GARS_C,GARS_N k59_737194_1 399739.Pmen_2153 2.32e-82 260.0 COG0665@1|root,COG0665@2|Bacteria,1Q38Q@1224|Proteobacteria,1RRYT@1236|Gammaproteobacteria,1YF7U@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria E Thi4 family - - - - - - - - - - - - DAO k59_115782_2 338963.Pcar_1708 2.44e-20 90.9 COG1074@1|root,COG1074@2|Bacteria,1MUTF@1224|Proteobacteria,42NKH@68525|delta/epsilon subdivisions,2WJTY@28221|Deltaproteobacteria,43S3Q@69541|Desulfuromonadales 28221|Deltaproteobacteria L PD-(D/E)XK nuclease superfamily - - - - - - - - - - - - PDDEXK_1,UvrD-helicase,UvrD_C k59_228337_1 314254.OA2633_06489 4.95e-86 263.0 COG0022@1|root,COG0022@2|Bacteria,1R8KB@1224|Proteobacteria,2TRFK@28211|Alphaproteobacteria,43WRP@69657|Hyphomonadaceae 28211|Alphaproteobacteria C Transketolase, pyrimidine binding domain bkdA2 - 1.2.4.4 ko:K00167 ko00280,ko00640,ko01100,ko01110,ko01130,map00280,map00640,map01100,map01110,map01130 M00036 R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997 RC00027,RC00627,RC02743,RC02883,RC02949,RC02953 br01601,ko00000,ko00001,ko00002,ko01000 - - - Transket_pyr,Transketolase_C k59_962843_1 1122137.AQXF01000002_gene442 5.31e-06 47.0 COG0334@1|root,COG0334@2|Bacteria,1MUXS@1224|Proteobacteria,2VGKD@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Belongs to the Glu Leu Phe Val dehydrogenases family - - 1.4.1.9 ko:K00263 ko00280,ko00290,ko01100,ko01110,ko01130,map00280,map00290,map01100,map01110,map01130 - R01088,R01434,R02196 RC00006,RC00036 ko00000,ko00001,ko01000 - - - ELFV_dehydrog,ELFV_dehydrog_N k59_962843_2 1207063.P24_16300 4.66e-89 295.0 COG1014@1|root,COG4231@1|root,COG1014@2|Bacteria,COG4231@2|Bacteria,1MUKS@1224|Proteobacteria,2TSHH@28211|Alphaproteobacteria,2JQ67@204441|Rhodospirillales 204441|Rhodospirillales C COG4231 Indolepyruvate ferredoxin oxidoreductase, alpha and beta subunits - - 1.2.7.8 ko:K04090 - - - - br01601,ko00000,ko01000 - - - POR,TPP_enzyme_C k59_286338_1 398511.BpOF4_02550 9.03e-30 114.0 COG3639@1|root,COG3639@2|Bacteria,1TR1S@1239|Firmicutes,4HBT8@91061|Bacilli,1ZB5I@1386|Bacillus 91061|Bacilli P ABC transporter - - - ko:K02042 ko02010,map02010 M00223 - - ko00000,ko00001,ko00002,ko02000 3.A.1.9 - - BPD_transp_1 k59_455568_1 350058.Mvan_3965 6.62e-44 163.0 COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,2GKXV@201174|Actinobacteria,235IC@1762|Mycobacteriaceae 201174|Actinobacteria C ferredoxin oxidoreductase korA GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0030312,GO:0044464,GO:0050896,GO:0055114,GO:0071944 1.2.7.11,1.2.7.3 ko:K00174 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - PFOR_II,POR,POR_N k59_1076749_1 13690.CP98_03807 3.75e-92 285.0 COG2274@1|root,COG2274@2|Bacteria,1MXTI@1224|Proteobacteria,2TUN0@28211|Alphaproteobacteria,2K1TC@204457|Sphingomonadales 204457|Sphingomonadales V ABC transporter, ATP-binding protein - - - ko:K02021 - - - - ko00000,ko02000 3.A.1.106,3.A.1.110,3.A.1.112,3.A.1.113,3.A.1.117,3.A.1.21 - - ABC_membrane,ABC_tran k59_1189981_1 379066.GAU_0391 4.07e-30 123.0 COG2120@1|root,COG2120@2|Bacteria,1ZT6U@142182|Gemmatimonadetes 142182|Gemmatimonadetes S GlcNAc-PI de-N-acetylase - - - - - - - - - - - - PIG-L k59_794727_1 378806.STAUR_8292 3.79e-69 232.0 COG1501@1|root,COG1501@2|Bacteria,1MWNJ@1224|Proteobacteria 1224|Proteobacteria G Belongs to the glycosyl hydrolase 31 family - - 3.2.1.20 ko:K01187 ko00052,ko00500,ko01100,map00052,map00500,map01100 - R00028,R00801,R00802,R06087,R06088 RC00028,RC00049,RC00077 ko00000,ko00001,ko01000 - GH31 - DUF4968,DUF5110,Gal_mutarotas_2,Glyco_hydro_31 k59_964007_1 1196323.ALKF01000196_gene2103 6.71e-10 65.1 COG5002@1|root,COG5002@2|Bacteria,1TQ1H@1239|Firmicutes,4HA52@91061|Bacilli,26RDT@186822|Paenibacillaceae 91061|Bacilli T Histidine kinase vicK - 2.7.13.3 ko:K07652 ko02020,map02020 M00459 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,HisKA,PAS,PAS_9 k59_1303162_1 1229909.NSED_08535 1.22e-32 122.0 arCOG07810@1|root,arCOG07810@2157|Archaea,41T4X@651137|Thaumarchaeota 651137|Thaumarchaeota T COG2114 Adenylate cyclase, family 3 (some proteins contain HAMP domain) - - 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 - - - Guanylate_cyc k59_3692_1 1112274.KI911560_gene1213 1.31e-99 302.0 COG0788@1|root,COG0788@2|Bacteria,1MVCF@1224|Proteobacteria,2VIXE@28216|Betaproteobacteria,2KM5N@206350|Nitrosomonadales 206350|Nitrosomonadales F Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4) purU - 3.5.1.10 ko:K01433 ko00630,ko00670,map00630,map00670 - R00944 RC00026,RC00111 ko00000,ko00001,ko01000 - - - ACT,Formyl_trans_N k59_1529010_1 745014.OMB55_00011950 7.73e-08 52.4 COG3114@1|root,COG3114@2|Bacteria,1NGBM@1224|Proteobacteria,1SGGH@1236|Gammaproteobacteria 1236|Gammaproteobacteria U Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes ccmD GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0009898,GO:0015886,GO:0016020,GO:0031224,GO:0031226,GO:0031235,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051181,GO:0051234,GO:0071702,GO:0071705,GO:0071944,GO:0098552,GO:0098562,GO:1901678 - ko:K02196 ko02010,map02010 - - - ko00000,ko00001,ko02000 3.A.1.107 - iB21_1397.B21_02084,iBWG_1329.BWG_1971,iE2348C_1286.E2348C_2342,iEC042_1314.EC042_2439,iEC55989_1330.EC55989_2451,iECABU_c1320.ECABU_c25320,iECBD_1354.ECBD_1462,iECB_1328.ECB_02125,iECDH10B_1368.ECDH10B_2355,iECDH1ME8569_1439.ECDH1ME8569_2133,iECD_1391.ECD_02125,iECED1_1282.ECED1_2663,iECH74115_1262.ECH74115_3335,iECIAI1_1343.ECIAI1_2280,iECIAI39_1322.ECIAI39_2336,iECNA114_1301.ECNA114_2290,iECO103_1326.ECO103_2673,iECO111_1330.ECO111_2934,iECO26_1355.ECO26_3124,iECOK1_1307.ECOK1_2432,iECP_1309.ECP_2238,iECS88_1305.ECS88_2345,iECSE_1348.ECSE_2466,iECSF_1327.ECSF_2079,iECSP_1301.ECSP_3077,iECUMN_1333.ECUMN_2533,iECs_1301.ECs3087,iEKO11_1354.EKO11_1558,iETEC_1333.ETEC_2332,iEcDH1_1363.EcDH1_1461,iEcE24377_1341.EcE24377A_2497,iEcHS_1320.EcHS_A2336,iEcSMS35_1347.EcSMS35_2346,iEcolC_1368.EcolC_1452,iJO1366.b2198,iLF82_1304.LF82_0276,iNRG857_1313.NRG857_11155,iSDY_1059.SDY_0880,iSFV_1184.SFV_2274,iSF_1195.SF2282,iSSON_1240.SSON_2256,iS_1188.S2412,iUMN146_1321.UM146_05815,iUMNK88_1353.UMNK88_2745,iUTI89_1310.UTI89_C2476,iY75_1357.Y75_RS11500,iZ_1308.Z3455,ic_1306.c2735 CcmD k59_1529010_2 1209072.ALBT01000011_gene3138 4.78e-43 145.0 COG2332@1|root,COG2332@2|Bacteria,1RHN5@1224|Proteobacteria,1S5VA@1236|Gammaproteobacteria,1FH75@10|Cellvibrio 1236|Gammaproteobacteria O Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH ccmE GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006807,GO:0006810,GO:0008150,GO:0008152,GO:0009897,GO:0009986,GO:0009987,GO:0015886,GO:0016020,GO:0016043,GO:0017003,GO:0017004,GO:0017006,GO:0018063,GO:0019538,GO:0020037,GO:0022607,GO:0031224,GO:0031226,GO:0031233,GO:0031237,GO:0034622,GO:0036211,GO:0043170,GO:0043412,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0046906,GO:0048037,GO:0051179,GO:0051181,GO:0051234,GO:0065003,GO:0071702,GO:0071704,GO:0071705,GO:0071840,GO:0071944,GO:0097159,GO:0098552,GO:0098567,GO:1901363,GO:1901564,GO:1901678 - ko:K02197 - - - - ko00000 - - iSSON_1240.SSON_2255 CcmE k59_1415857_1 377629.TERTU_4503 2.49e-86 271.0 COG0591@1|root,COG0591@2|Bacteria,1R4VK@1224|Proteobacteria,1RQFS@1236|Gammaproteobacteria,2PPQW@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria E Sodium:solute symporter family nanT - - ko:K03307 - - - - ko00000 2.A.21 - - SSF k59_738388_1 158500.BV97_01530 9.22e-67 206.0 2DT17@1|root,33I8E@2|Bacteria 2|Bacteria S SnoaL-like domain - - - - - - - - - - - - SnoaL_4 k59_738388_2 685035.ADAE01000018_gene991 1.25e-37 134.0 COG4221@1|root,COG4221@2|Bacteria,1RAAB@1224|Proteobacteria,2U69E@28211|Alphaproteobacteria,2K0MR@204457|Sphingomonadales 204457|Sphingomonadales S Enoyl-(Acyl carrier protein) reductase - - - - - - - - - - - - adh_short_C2 k59_794753_1 436308.Nmar_0651 3.49e-39 149.0 COG1196@1|root,arCOG00371@2157|Archaea,41SDS@651137|Thaumarchaeota 651137|Thaumarchaeota D SMC proteins Flexible Hinge Domain - - - ko:K03529 - - - - ko00000,ko03036 - - - SMC_N,SMC_hinge k59_1189989_1 338963.Pcar_1459 1.58e-28 114.0 COG0132@1|root,COG0132@2|Bacteria,1RDRK@1224|Proteobacteria,42SQE@68525|delta/epsilon subdivisions,2WPQK@28221|Deltaproteobacteria,43U6M@69541|Desulfuromonadales 28221|Deltaproteobacteria H Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring bioD - 6.3.3.3 ko:K01935 ko00780,ko01100,map00780,map01100 M00123,M00573,M00577 R03182 RC00868 ko00000,ko00001,ko00002,ko01000 - - - AAA_26 k59_1189989_2 562970.Btus_2598 7.27e-33 127.0 COG0161@1|root,COG0161@2|Bacteria,1TP9N@1239|Firmicutes,4H9QK@91061|Bacilli,2784C@186823|Alicyclobacillaceae 91061|Bacilli H Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor bioA - 2.6.1.105,2.6.1.62 ko:K00833,ko:K19563 ko00780,ko01100,map00780,map01100 M00123,M00573,M00577 R03231,R10699 RC00006,RC00062,RC00887 ko00000,ko00001,ko00002,ko01000,ko01007 - - iSB619.SA_RS12705 Aminotran_3 k59_794756_1 403833.Pmob_1727 7.31e-17 80.1 COG0031@1|root,COG0031@2|Bacteria,2GC3M@200918|Thermotogae 200918|Thermotogae E Pyridoxal-phosphate dependent enzyme - - - - - - - - - - - - PALP k59_794756_2 1121439.dsat_2228 1.65e-101 310.0 COG0498@1|root,COG0498@2|Bacteria,1MUWQ@1224|Proteobacteria,42M1W@68525|delta/epsilon subdivisions,2WPYW@28221|Deltaproteobacteria,2MC7X@213115|Desulfovibrionales 28221|Deltaproteobacteria E PFAM Pyridoxal-5'-phosphate-dependent protein beta subunit - - 4.2.3.1 ko:K01733 ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230 M00018 R01466,R05086 RC00017,RC00526 ko00000,ko00001,ko00002,ko01000 - - - PALP k59_1076764_2 436308.Nmar_1000 1.23e-63 211.0 arCOG11734@1|root,arCOG11734@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_738396_1 1245471.PCA10_12880 1.63e-18 85.9 COG1560@1|root,COG1560@2|Bacteria,1MVNI@1224|Proteobacteria,1RMZ5@1236|Gammaproteobacteria,1YEWC@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria M Catalyzes the transfer of laurate from lauroyl-acyl carrier protein (ACP) to Kdo(2)-lipid IV(A) to form Kdo(2)- (lauroyl)-lipid IV(A) lpxL GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0006082,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0006950,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0008951,GO:0009058,GO:0009245,GO:0009247,GO:0009266,GO:0009311,GO:0009312,GO:0009409,GO:0009628,GO:0009987,GO:0016020,GO:0016051,GO:0016053,GO:0016740,GO:0016746,GO:0016747,GO:0019637,GO:0019752,GO:0036103,GO:0036104,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046467,GO:0046493,GO:0050896,GO:0071704,GO:0071944,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 2.3.1.241,2.3.1.242 ko:K02517,ko:K12974 ko00540,ko01100,map00540,map01100 M00060 R05146,R10906 RC00037,RC00039 ko00000,ko00001,ko00002,ko01000,ko01005 - - iEC042_1314.EC042_2597,iSF_1195.SF1061,iS_1188.S1138,iYL1228.KPN_01068 Lip_A_acyltrans k59_738396_2 1336233.JAEH01000005_gene1869 8.65e-05 45.1 COG1519@1|root,COG1519@2|Bacteria,1MU9F@1224|Proteobacteria,1RNBR@1236|Gammaproteobacteria,2Q9SW@267890|Shewanellaceae 1236|Gammaproteobacteria M PFAM Three-deoxy-D-manno-octulosonic-acid transferase domain protein waaA GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016740,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044464,GO:0046467,GO:0046493,GO:0071704,GO:0071944,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15 ko:K02527 ko00540,ko01100,map00540,map01100 M00060,M00080 R04658,R05074,R09763 RC00009,RC00077,RC00247 ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT30 iECNA114_1301.ECNA114_3778,iUMNK88_1353.UMNK88_4417 Glycos_transf_1,Glycos_transf_N k59_229495_1 1121346.KB899820_gene2794 1.96e-13 74.3 COG2936@1|root,COG2936@2|Bacteria,1TT0H@1239|Firmicutes,4HC37@91061|Bacilli,26TMF@186822|Paenibacillaceae 91061|Bacilli S X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain - - - ko:K06978 - - - - ko00000 - - - PepX_C,Peptidase_S15 k59_738402_1 1288826.MSNKSG1_14177 6.68e-55 186.0 COG0598@1|root,COG0598@2|Bacteria,1MW8W@1224|Proteobacteria,1RRTZ@1236|Gammaproteobacteria,464S0@72275|Alteromonadaceae 1236|Gammaproteobacteria P CorA-like Mg2+ transporter protein zntB GO:0000041,GO:0003674,GO:0005215,GO:0005385,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006829,GO:0008150,GO:0008324,GO:0015075,GO:0015318,GO:0015562,GO:0016020,GO:0016021,GO:0022857,GO:0022883,GO:0022890,GO:0030001,GO:0031224,GO:0031226,GO:0034220,GO:0044425,GO:0044459,GO:0044464,GO:0046583,GO:0046873,GO:0046915,GO:0051179,GO:0051234,GO:0055085,GO:0070838,GO:0071577,GO:0071944,GO:0072509,GO:0072511,GO:0098655,GO:0098660,GO:0098662 - ko:K16074 - - - - ko00000,ko02000 1.A.35.4 - - CorA k59_964043_1 1265313.HRUBRA_00544 1.77e-61 206.0 COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,1RQUR@1236|Gammaproteobacteria,1J54K@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria F Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen nrdZ - 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - Intein_splicing,LAGLIDADG_3,Ribonuc_red_lgC,Ribonuc_red_lgN k59_964043_2 1255043.TVNIR_3567 5.92e-100 297.0 COG0209@1|root,COG0209@2|Bacteria,1P4EH@1224|Proteobacteria,1RP1A@1236|Gammaproteobacteria 1236|Gammaproteobacteria F COG0209 Ribonucleotide reductase, alpha subunit nrdJb - - - - - - - - - - - - k59_964043_3 1379701.JPJC01000249_gene809 5.17e-09 55.5 2DM9Y@1|root,32AJ6@2|Bacteria,1N98N@1224|Proteobacteria,2UFUN@28211|Alphaproteobacteria,2K7UM@204457|Sphingomonadales 204457|Sphingomonadales - - - - - - - - - - - - - - - k59_342925_1 545276.KB898724_gene1817 4.17e-117 359.0 COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,1RPCB@1236|Gammaproteobacteria,1WWYF@135613|Chromatiales 135613|Chromatiales O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner lon - 3.4.21.53 ko:K01338 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - AAA,LON_substr_bdg,Lon_C k59_399203_1 436308.Nmar_0037 4.14e-131 376.0 COG0602@1|root,arCOG02173@2157|Archaea,41SGM@651137|Thaumarchaeota 651137|Thaumarchaeota O Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds queE - 4.3.99.3 ko:K10026 ko00790,ko01100,map00790,map01100 - R10002 RC02989 ko00000,ko00001,ko01000,ko03016 - - - Fer4_12,Radical_SAM k59_116980_1 203122.Sde_0507 2.08e-157 450.0 COG2152@1|root,COG2152@2|Bacteria,1MX8M@1224|Proteobacteria,1RYFR@1236|Gammaproteobacteria,464HT@72275|Alteromonadaceae 1236|Gammaproteobacteria G Converts 4-O-beta-D-mannopyranosyl-D-glucopyranose (Man- Glc) to mannose 1-phosphate (Man1P) and glucose - - 2.4.1.281 ko:K16212 - - R09943 RC00049 ko00000,ko01000 - - - Glyco_hydro_130 k59_342934_1 298653.Franean1_5142 4.23e-58 206.0 COG0342@1|root,COG0342@2|Bacteria,2GJTT@201174|Actinobacteria,4ERTD@85013|Frankiales 201174|Actinobacteria U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA secD GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944 - ko:K03072 ko03060,ko03070,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 2.A.6.4,3.A.5.2,3.A.5.7 - - SecD_SecF,Sec_GG k59_60465_1 411459.RUMOBE_00718 1.09e-35 140.0 2FFDF@1|root,347B2@2|Bacteria,1VYJJ@1239|Firmicutes,256XH@186801|Clostridia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - - k59_1189999_1 983920.Y88_1253 7.8e-19 84.3 COG0538@1|root,COG0538@2|Bacteria,1MUIB@1224|Proteobacteria,2TQWD@28211|Alphaproteobacteria,2K05F@204457|Sphingomonadales 204457|Sphingomonadales C Belongs to the isocitrate and isopropylmalate dehydrogenases family icd - 1.1.1.42 ko:K00031 ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146 M00009,M00010,M00173,M00740 R00267,R00268,R01899 RC00001,RC00084,RC00114,RC00626,RC02801 br01601,ko00000,ko00001,ko00002,ko01000 - - - Iso_dh k59_1189999_2 1122137.AQXF01000002_gene404 8.48e-83 250.0 COG1611@1|root,COG1611@2|Bacteria,1RD59@1224|Proteobacteria,2U5DP@28211|Alphaproteobacteria 28211|Alphaproteobacteria K Belongs to the LOG family yvdD - 3.2.2.10 ko:K06966 ko00230,ko00240,map00230,map00240 - R00182,R00510 RC00063,RC00318 ko00000,ko00001,ko01000 - - - Lysine_decarbox k59_1472518_1 1488328.JMCL01000057_gene1142 7.28e-80 253.0 COG3385@1|root,COG3385@2|Bacteria 2|Bacteria L transposase activity - - - - - - - - - - - - DDE_Tnp_1,Nterm_IS4 k59_1754893_1 998088.B565_3883 3.31e-59 189.0 COG1974@1|root,COG1974@2|Bacteria,1MW80@1224|Proteobacteria,1RMXF@1236|Gammaproteobacteria,1Y45U@135624|Aeromonadales 135624|Aeromonadales K Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair lexA - 3.4.21.88 ko:K01356 - M00729 - - ko00000,ko00002,ko01000,ko01002,ko03400 - - - LexA_DNA_bind,Peptidase_S24 k59_1133513_1 690585.JNNU01000017_gene283 2.98e-84 263.0 COG0014@1|root,COG0014@2|Bacteria,1MUGJ@1224|Proteobacteria,2TS83@28211|Alphaproteobacteria,4B70Z@82115|Rhizobiaceae 28211|Alphaproteobacteria E Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate proA GO:0003674,GO:0003824,GO:0004350,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0055114 1.2.1.41 ko:K00147 ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230 M00015 R03313 RC00684 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_399224_1 555793.WSK_2722 6.64e-122 360.0 COG3000@1|root,COG3000@2|Bacteria,1R646@1224|Proteobacteria,2U1PJ@28211|Alphaproteobacteria,2K0N0@204457|Sphingomonadales 204457|Sphingomonadales I Fatty acid hydroxylase superfamily - - - - - - - - - - - - FA_hydroxylase k59_851268_2 1122137.AQXF01000004_gene1822 7.54e-18 75.1 2BRAS@1|root,32K9A@2|Bacteria,1Q2QN@1224|Proteobacteria,2UJR1@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_851268_3 1122137.AQXF01000004_gene1821 8.28e-62 194.0 COG0703@1|root,COG0703@2|Bacteria,1MUFJ@1224|Proteobacteria,2U76C@28211|Alphaproteobacteria 28211|Alphaproteobacteria F Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate aroK GO:0000287,GO:0003674,GO:0003824,GO:0004765,GO:0005488,GO:0006082,GO:0006520,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019438,GO:0019632,GO:0019752,GO:0032787,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046872,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615 2.7.1.71 ko:K00891 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02412 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - SKI k59_1020974_1 497964.CfE428DRAFT_0662 1.08e-38 134.0 2EAUB@1|root,334VZ@2|Bacteria,46VV5@74201|Verrucomicrobia 74201|Verrucomicrobia - - - - - - - - - - - - - - - k59_1076814_1 1144307.PMI04_00622 2.11e-36 133.0 COG2030@1|root,COG2030@2|Bacteria,1NTV7@1224|Proteobacteria,2UQFU@28211|Alphaproteobacteria,2K8I3@204457|Sphingomonadales 204457|Sphingomonadales I N-terminal half of MaoC dehydratase - - - - - - - - - - - - MaoC_dehydrat_N k59_1190033_1 1487956.DR71_1270 3.33e-17 85.9 COG1009@1|root,COG1009@2|Bacteria,2GIT4@201174|Actinobacteria,22JKT@1653|Corynebacteriaceae 201174|Actinobacteria CP NADH ubiquinone oxidoreductase subunit 5 (Chain L) Multisubunit Na H antiporter, MnhA subunit mnhB - - ko:K05565,ko:K14086 - - - - ko00000,ko02000 2.A.63.1,2.A.63.2 - - DUF4040,MnhB,NADHdh,Proton_antipo_M,Proton_antipo_N k59_1415916_1 436308.Nmar_0063 3.55e-132 387.0 COG0423@1|root,arCOG00405@2157|Archaea,41S8S@651137|Thaumarchaeota 651137|Thaumarchaeota J synthetase (class II) - - 6.1.1.14 ko:K01880 ko00970,map00970 M00359,M00360 R03654 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - HGTP_anticodon,tRNA-synt_2b k59_1303214_1 32057.KB217483_gene9237 3.32e-43 155.0 COG0659@1|root,COG0659@2|Bacteria 2|Bacteria P secondary active sulfate transmembrane transporter activity ychM - - - - - - - - - - - STAS_2,Sulfate_transp k59_1698460_1 466038.KI421440_gene1280 3.61e-123 369.0 COG0441@1|root,COG0441@2|Bacteria,1MUP2@1224|Proteobacteria,2TQWI@28211|Alphaproteobacteria,4BPFD@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria J Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) thrS - 6.1.1.3 ko:K01868 ko00970,map00970 M00359,M00360 R03663 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,TGS,tRNA-synt_2b,tRNA_SAD k59_286427_1 1097668.BYI23_A025610 4.06e-09 58.5 COG0617@1|root,COG0617@2|Bacteria,1MU2X@1224|Proteobacteria,2VIN5@28216|Betaproteobacteria,1K1SK@119060|Burkholderiaceae 28216|Betaproteobacteria J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. Also shows phosphatase, 2'- nucleotidase and 2',3'-cyclic phosphodiesterase activities. These phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases cca - 2.7.7.72 ko:K00974 ko03013,map03013 - R09382,R09383,R09384,R09386 RC00078 ko00000,ko00001,ko01000,ko03016 - - - HD,PolyA_pol,PolyA_pol_RNAbd k59_286427_2 930169.B5T_01909 1.41e-39 141.0 COG1968@1|root,COG1968@2|Bacteria,1MX02@1224|Proteobacteria,1RQQT@1236|Gammaproteobacteria,1XH3U@135619|Oceanospirillales 135619|Oceanospirillales V Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin uppP - 3.6.1.27 ko:K06153 ko00550,map00550 - R05627 RC00002 ko00000,ko00001,ko01000,ko01011 - - - BacA k59_173455_1 160488.PP_0008 4.55e-16 75.1 COG0594@1|root,COG0594@2|Bacteria,1MZQE@1224|Proteobacteria,1S90M@1236|Gammaproteobacteria,1YYRZ@136845|Pseudomonas putida group 1236|Gammaproteobacteria J RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme rnpA GO:0000966,GO:0001682,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004526,GO:0004540,GO:0004549,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005655,GO:0005730,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0030677,GO:0030681,GO:0031974,GO:0031981,GO:0032991,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0044237,GO:0044238,GO:0044422,GO:0044424,GO:0044428,GO:0044446,GO:0044452,GO:0044464,GO:0046483,GO:0070013,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0099116,GO:0140098,GO:0140101,GO:1901360,GO:1902494,GO:1902555,GO:1905348,GO:1990904 3.1.26.5 ko:K03536 - - - - ko00000,ko01000,ko03016 - - - Ribonuclease_P k59_512056_1 1380390.JIAT01000009_gene559 1.26e-94 317.0 COG1014@1|root,COG4231@1|root,COG1014@2|Bacteria,COG4231@2|Bacteria,2GKBW@201174|Actinobacteria,4CPFA@84995|Rubrobacteria 84995|Rubrobacteria C Pyruvate ferredoxin/flavodoxin oxidoreductase - - 1.2.7.8 ko:K04090 - - - - br01601,ko00000,ko01000 - - - POR,TPP_enzyme_C k59_907495_1 1249634.D781_4192 6.25e-32 117.0 COG1974@1|root,COG1974@2|Bacteria,1MW80@1224|Proteobacteria,1RMXF@1236|Gammaproteobacteria,400DF@613|Serratia 1236|Gammaproteobacteria K Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. Binds to the 16 bp palindromic sequence 5'-CTGTATATATATACAG-3'. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair lexA GO:0000976,GO:0001067,GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006282,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009432,GO:0009605,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0009991,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031668,GO:0032774,GO:0032991,GO:0032993,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0042802,GO:0043170,GO:0043565,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045934,GO:0046483,GO:0048519,GO:0048523,GO:0048583,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051716,GO:0060255,GO:0065007,GO:0071496,GO:0071704,GO:0080090,GO:0080134,GO:0080135,GO:0090304,GO:0097159,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2001020,GO:2001141 3.4.21.88 ko:K01356 - M00729 - - ko00000,ko00002,ko01000,ko01002,ko03400 - - - LexA_DNA_bind,Peptidase_S24 k59_907495_2 1260251.SPISAL_05925 1.53e-07 54.7 COG4544@1|root,COG4544@2|Bacteria,1MZQU@1224|Proteobacteria,1S9RP@1236|Gammaproteobacteria,1WZQP@135613|Chromatiales 135613|Chromatiales D Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division - - - ko:K14160 - - - - ko00000,ko03400 - - - SulA k59_1642145_1 1122137.AQXF01000001_gene3185 1.71e-75 249.0 COG0249@1|root,COG0249@2|Bacteria,1MUGX@1224|Proteobacteria,2TQRR@28211|Alphaproteobacteria 28211|Alphaproteobacteria L that it carries out the mismatch recognition step. This protein has a weak ATPase activity mutS GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - ko:K03555 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V k59_1076841_1 1122137.AQXF01000006_gene727 9.67e-64 199.0 COG4665@1|root,COG4665@2|Bacteria,1RK2F@1224|Proteobacteria,2UAK5@28211|Alphaproteobacteria 28211|Alphaproteobacteria Q COG4665 TRAP-type mannitol chloroaromatic compound transport system, small permease component - - - - - - - - - - - - DctQ k59_1076841_2 1122137.AQXF01000006_gene726 1.22e-44 155.0 COG4663@1|root,COG4663@2|Bacteria,1MVMD@1224|Proteobacteria,2TS4J@28211|Alphaproteobacteria 28211|Alphaproteobacteria Q Part of the tripartite ATP-independent periplasmic (TRAP) transport system - - - - - - - - - - - - DctP k59_907503_1 558169.AGAV01000018_gene3569 2.21e-78 251.0 COG0155@1|root,COG0155@2|Bacteria,1TS58@1239|Firmicutes,4HBEX@91061|Bacilli 91061|Bacilli P Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate cysI GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0006790,GO:0008150,GO:0008152,GO:0009337,GO:0009987,GO:0016002,GO:0016491,GO:0016667,GO:0016673,GO:0019419,GO:0032991,GO:0044237,GO:0044424,GO:0044464,GO:0050311,GO:0055114 1.8.1.2,1.8.7.1 ko:K00381,ko:K00392 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00176 R00858,R00859,R03600 RC00065 ko00000,ko00001,ko00002,ko01000 - - - NIR_SIR,NIR_SIR_ferr k59_738517_1 436308.Nmar_1785 5.37e-152 437.0 COG0446@1|root,arCOG01064@2157|Archaea,41SZR@651137|Thaumarchaeota 651137|Thaumarchaeota S Pyridine nucleotide-disulphide oxidoreductase - - 1.8.5.4 ko:K17218 ko00920,map00920 - R10152 RC03155 ko00000,ko00001,ko01000 - - - Pyr_redox_2 k59_738517_2 436308.Nmar_1784 3.56e-25 95.1 arCOG08810@1|root,arCOG08810@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_964139_1 643562.Daes_1404 2.63e-28 113.0 COG3494@1|root,COG3494@2|Bacteria,1MWTH@1224|Proteobacteria,42P40@68525|delta/epsilon subdivisions,2WK7K@28221|Deltaproteobacteria,2M8IK@213115|Desulfovibrionales 28221|Deltaproteobacteria S Protein of unknown function (DUF1009) - - - ko:K09949 - - - - ko00000 - - - DUF1009 k59_1642153_1 43989.cce_4658 3.2e-153 446.0 COG2046@1|root,COG2046@2|Bacteria,1G0E8@1117|Cyanobacteria,3KGNQ@43988|Cyanothece 1117|Cyanobacteria H Belongs to the sulfate adenylyltransferase family sat - 2.7.7.4 ko:K00958 ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130 M00176,M00596 R00529,R04929 RC02809,RC02889 ko00000,ko00001,ko00002,ko01000 - - - ATP-sulfurylase,PUA_2 k59_907514_1 983920.Y88_0800 4.11e-92 283.0 COG0008@1|root,COG0008@2|Bacteria,1MUCR@1224|Proteobacteria,2TRSU@28211|Alphaproteobacteria,2K09A@204457|Sphingomonadales 204457|Sphingomonadales J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) gltX1 - 6.1.1.17 ko:K01885 ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120 M00121,M00359,M00360 R05578 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016 - - - tRNA-synt_1c k59_625095_1 381764.Fnod_0450 1.99e-78 253.0 COG1653@1|root,COG1653@2|Bacteria,2GC1I@200918|Thermotogae 200918|Thermotogae G PFAM extracellular solute-binding protein family 1 - - - ko:K02027,ko:K10236 ko02010,map02010 M00204,M00207 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1,3.A.1.1.17 - - SBP_bac_1,SBP_bac_8 k59_1312160_1 1120953.AUBH01000003_gene1901 2.01e-37 135.0 COG0714@1|root,COG0714@2|Bacteria,1MUFN@1224|Proteobacteria,1RN5G@1236|Gammaproteobacteria,464XH@72275|Alteromonadaceae 1236|Gammaproteobacteria S COG0714 MoxR-like ATPases - - - ko:K03924 - - - - ko00000,ko01000 - - - AAA_3 k59_1312160_2 1249627.D779_1447 5.87e-24 100.0 COG1721@1|root,COG1721@2|Bacteria,1Q7RR@1224|Proteobacteria,1RNNP@1236|Gammaproteobacteria,1WWS2@135613|Chromatiales 135613|Chromatiales S Protein of unknown function DUF58 - - - - - - - - - - - - DUF58 k59_1650861_1 1532557.JL37_04845 6.44e-40 150.0 COG4231@1|root,COG4231@2|Bacteria,1MUKS@1224|Proteobacteria,2VK1K@28216|Betaproteobacteria,3T1XW@506|Alcaligenaceae 28216|Betaproteobacteria C Thiamine pyrophosphate enzyme, C-terminal TPP binding - - 1.2.7.8 ko:K00179 - - - - br01601,ko00000,ko01000 - - - TPP_enzyme_C k59_803788_1 1089551.KE386572_gene1791 2.16e-57 192.0 COG0774@1|root,COG0774@2|Bacteria,1MV6T@1224|Proteobacteria,2TUHH@28211|Alphaproteobacteria,4BQ38@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria M Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis lpxC - 3.5.1.108 ko:K02535 ko00540,ko01100,map00540,map01100 M00060 R04587 RC00166,RC00300 ko00000,ko00001,ko00002,ko01000,ko01005 - - - LpxC k59_690126_1 42256.RradSPS_0172 6.57e-29 112.0 COG1216@1|root,COG1216@2|Bacteria,2IIII@201174|Actinobacteria 201174|Actinobacteria S Glycosyl transferase, family 2 - - - - - - - - - - - - - k59_1538014_1 1163408.UU9_09337 6.49e-48 168.0 COG1070@1|root,COG1070@2|Bacteria,1MW4A@1224|Proteobacteria,1RR7X@1236|Gammaproteobacteria,1X4TN@135614|Xanthomonadales 135614|Xanthomonadales G Xylulose kinase xylB - 2.7.1.17 ko:K00854 ko00040,ko01100,map00040,map01100 M00014 R01639 RC00002,RC00538 ko00000,ko00001,ko00002,ko01000 - - - FGGY_C,FGGY_N k59_1538014_2 498211.CJA_3063 3.91e-17 80.5 COG1051@1|root,COG1051@2|Bacteria,1QTT4@1224|Proteobacteria,1RQ35@1236|Gammaproteobacteria,1FGE6@10|Cellvibrio 1236|Gammaproteobacteria F NUDIX domain nuhA - - - - - - - - - - - NUDIX k59_1198670_1 95619.PM1_0226240 9.74e-76 243.0 COG4452@1|root,COG4452@2|Bacteria,1MVVR@1224|Proteobacteria,1RQRZ@1236|Gammaproteobacteria 1236|Gammaproteobacteria V Inner membrane protein involved in colicin E2 resistance creD GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K06143 - - - - ko00000 - - - CreD k59_1650869_1 1144307.PMI04_00161 2.62e-112 330.0 COG2301@1|root,COG2301@2|Bacteria,1MW0A@1224|Proteobacteria,2TTC0@28211|Alphaproteobacteria,2K2E1@204457|Sphingomonadales 204457|Sphingomonadales G Belongs to the HpcH HpaI aldolase family - - 4.1.3.34 ko:K01644 ko02020,map02020 - R00362 RC00067,RC01118 ko00000,ko00001,ko01000 - - - HpcH_HpaI k59_690139_1 946362.XP_004996879.1 2.35e-31 116.0 COG0317@1|root,KOG1157@2759|Eukaryota,39Y6C@33154|Opisthokonta 33154|Opisthokonta T HD domain containing 3 HDDC3 GO:0003674,GO:0003824,GO:0006139,GO:0006152,GO:0006163,GO:0006195,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008893,GO:0009056,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009150,GO:0009154,GO:0009164,GO:0009166,GO:0009259,GO:0009261,GO:0009605,GO:0009987,GO:0009991,GO:0015969,GO:0015971,GO:0016787,GO:0016788,GO:0016794,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0031667,GO:0033865,GO:0033869,GO:0033875,GO:0034031,GO:0034032,GO:0034034,GO:0034035,GO:0034037,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0042278,GO:0042454,GO:0042578,GO:0042594,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0046128,GO:0046130,GO:0046434,GO:0046483,GO:0046700,GO:0050896,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:1901068,GO:1901069,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1901657,GO:1901658 3.1.7.2 ko:K21138 ko00230,map00230 - R00336 RC00078 ko00000,ko00001,ko01000 - - - HD_4 k59_690139_2 237368.SCABRO_00086 3.21e-18 83.6 COG2887@1|root,COG2887@2|Bacteria 2|Bacteria L Belongs to the helicase family. UvrD subfamily - - 3.6.4.12 ko:K10742 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - AAA_24,PDDEXK_1 k59_295383_1 1122137.AQXF01000006_gene945 4.13e-227 637.0 COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,2TS6B@28211|Alphaproteobacteria 28211|Alphaproteobacteria M Belongs to the peptidase S1C family htrA2 GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006457,GO:0006508,GO:0006515,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0009056,GO:0009057,GO:0009266,GO:0009408,GO:0009628,GO:0009897,GO:0009986,GO:0009987,GO:0016020,GO:0016021,GO:0016787,GO:0017171,GO:0019538,GO:0030163,GO:0030288,GO:0030313,GO:0031224,GO:0031226,GO:0031233,GO:0031975,GO:0042597,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051603,GO:0061077,GO:0070011,GO:0071575,GO:0071704,GO:0071944,GO:0098552,GO:0140096,GO:1901564,GO:1901565,GO:1901575 3.4.21.107 ko:K04771 ko01503,ko02020,map01503,map02020 M00728 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 - - - PDZ_2,Trypsin_2 k59_181928_1 1537715.JQFJ01000002_gene2137 1.65e-100 305.0 COG0246@1|root,COG0246@2|Bacteria,1MVZ7@1224|Proteobacteria,2TRBE@28211|Alphaproteobacteria,2JZW9@204457|Sphingomonadales 204457|Sphingomonadales G PFAM Mannitol dehydrogenase - - 1.1.1.57,1.1.1.67 ko:K00040,ko:K00045 ko00040,ko00051,ko01100,map00040,map00051,map01100 M00061 R00868,R02454 RC00085 ko00000,ko00001,ko00002,ko01000 - - - Mannitol_dh,Mannitol_dh_C k59_295384_1 1538295.JY96_09185 1.33e-13 73.2 COG1595@1|root,COG1595@2|Bacteria,1N00E@1224|Proteobacteria,2VQNP@28216|Betaproteobacteria,1KMJJ@119065|unclassified Burkholderiales 28216|Betaproteobacteria K Belongs to the sigma-70 factor family. ECF subfamily rpoE1 - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4,Sigma70_r4_2 k59_690146_1 1484460.JSWG01000009_gene3 6.48e-90 285.0 COG4953@1|root,COG4953@2|Bacteria,4NEG5@976|Bacteroidetes,1HWRT@117743|Flavobacteriia 976|Bacteroidetes M penicillin-binding protein pbpC - 2.4.1.129 ko:K05367 ko00550,map00550 - - - ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 - BiPBP_C,Transgly,Transpeptidase k59_1594122_1 998674.ATTE01000001_gene581 6.63e-96 301.0 COG2225@1|root,COG2225@2|Bacteria,1MVEV@1224|Proteobacteria,1RPVI@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA glcB - 2.3.3.9 ko:K01638 ko00620,ko00630,ko01100,ko01110,ko01120,ko01200,map00620,map00630,map01100,map01110,map01120,map01200 M00012 R00472 RC00004,RC00308,RC02747 ko00000,ko00001,ko00002,ko01000 - - - Malate_synthase k59_1763613_2 223283.PSPTO_4319 8.84e-27 112.0 28IAG@1|root,2Z8D2@2|Bacteria,1P5EH@1224|Proteobacteria,1RYCA@1236|Gammaproteobacteria,1Z6K7@136849|Pseudomonas syringae group 1236|Gammaproteobacteria S Domain of unknown function (DUF4129) - - - - - - - - - - - - DUF4129 k59_1312196_1 742159.HMPREF0004_5475 9.52e-107 316.0 COG2159@1|root,COG2159@2|Bacteria,1R5PG@1224|Proteobacteria,2VPKM@28216|Betaproteobacteria,3T38J@506|Alcaligenaceae 28216|Betaproteobacteria S Amidohydrolase - - 4.1.1.45 ko:K03392 ko00380,ko01100,map00380,map01100 M00038 R04323 RC00779 ko00000,ko00001,ko00002,ko01000 - - - Amidohydro_2 k59_1594126_1 1318628.MARLIPOL_09189 1.89e-25 109.0 COG3391@1|root,COG3391@2|Bacteria,1R9D3@1224|Proteobacteria,1RP57@1236|Gammaproteobacteria 1236|Gammaproteobacteria S amine dehydrogenase activity - - - - - - - - - - - - - k59_1538036_1 1439940.BAY1663_01811 2.64e-63 220.0 COG0004@1|root,COG5001@1|root,COG0004@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria 1236|Gammaproteobacteria T Diguanylate cyclase - - 2.1.1.80,3.1.1.61 ko:K03320,ko:K13924 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko02000,ko02022,ko02035 1.A.11 - - Ammonium_transp,EAL,GGDEF,PAS,PAS_3,PAS_4,PAS_9 k59_1198694_2 391603.FBALC1_08108 0.000671 45.1 COG2939@1|root,COG2939@2|Bacteria,4NF48@976|Bacteroidetes,1HXGY@117743|Flavobacteriia 976|Bacteroidetes E COG2939 Carboxypeptidase C (cathepsin A) - - - - - - - - - - - - Peptidase_S10 k59_577296_1 1121015.N789_10480 1.5e-05 52.4 COG0666@1|root,COG0666@2|Bacteria,1R2FT@1224|Proteobacteria,1SJ5W@1236|Gammaproteobacteria,1X8QR@135614|Xanthomonadales 135614|Xanthomonadales S response to abiotic stimulus - - - - - - - - - - - - - k59_633583_1 436308.Nmar_0332 6.71e-118 350.0 COG0053@1|root,arCOG01474@2157|Archaea,arCOG01475@2157|Archaea,41SXN@651137|Thaumarchaeota 651137|Thaumarchaeota P cation diffusion facilitator family transporter - - - - - - - - - - - - Cation_efflux,ZT_dimer k59_633583_2 1229909.NSED_01590 2.98e-61 201.0 COG0428@1|root,arCOG00576@2157|Archaea,41S6R@651137|Thaumarchaeota 651137|Thaumarchaeota P divalent heavy-metal cations transporter - - - - - - - - - - - - - k59_1650892_1 1088721.NSU_0701 3.64e-99 312.0 COG4773@1|root,COG4773@2|Bacteria,1QUTS@1224|Proteobacteria,2TSII@28211|Alphaproteobacteria,2K0JB@204457|Sphingomonadales 204457|Sphingomonadales P COG1629 Outer membrane receptor proteins, mostly Fe transport - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_1255176_1 1266908.AQPB01000032_gene1762 1.05e-51 169.0 COG0247@1|root,COG0247@2|Bacteria,1RF02@1224|Proteobacteria,1S302@1236|Gammaproteobacteria,1WX78@135613|Chromatiales 135613|Chromatiales C Protein of unknown function (DUF3501) - - - - - - - - - - - - DUF3501 k59_577301_1 679926.Mpet_2249 8.22e-46 152.0 COG1513@1|root,arCOG01488@2157|Archaea,2XXG9@28890|Euryarchaeota,2N9M3@224756|Methanomicrobia 224756|Methanomicrobia F MafB19-like deaminase codA - 3.5.4.1 ko:K01485 ko00240,ko00330,ko01100,map00240,map00330,map01100 - R00974,R01411,R02922 RC00074,RC00514,RC00809 ko00000,ko00001,ko01000 - - - dCMP_cyt_deam_1 k59_1706843_1 158500.BV97_03275 3.3e-112 341.0 COG0145@1|root,COG0145@2|Bacteria,1MU2Y@1224|Proteobacteria,2TQZ6@28211|Alphaproteobacteria,2K20D@204457|Sphingomonadales 204457|Sphingomonadales EQ PFAM Hydantoinase oxoprolinase - - 3.5.2.14 ko:K01473 ko00330,ko01100,map00330,map01100 - R03187 RC00632 ko00000,ko00001,ko01000 - - - Hydant_A_N,Hydantoinase_A k59_1594138_1 1357272.AVEO02000131_gene4842 4.15e-18 90.9 COG0642@1|root,COG0784@1|root,COG5002@1|root,COG0784@2|Bacteria,COG2205@2|Bacteria,COG5002@2|Bacteria,1NRP8@1224|Proteobacteria,1SKTW@1236|Gammaproteobacteria,1Z54F@136849|Pseudomonas syringae group 1236|Gammaproteobacteria T Histidine kinase barA GO:0000155,GO:0000160,GO:0000302,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006979,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009636,GO:0009927,GO:0009987,GO:0010033,GO:0010035,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0023014,GO:0023052,GO:0035556,GO:0036211,GO:0042221,GO:0042493,GO:0042542,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0046677,GO:0046777,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0060089,GO:0065007,GO:0070887,GO:0071310,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901700 2.7.13.3 ko:K07678 ko02020,ko02025,ko02026,ko05111,map02020,map02025,map02026,map05111 M00475 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - DUF2222,HAMP,HATPase_c,HisKA,Hpt,Response_reg k59_1424319_1 42256.RradSPS_0557 5.24e-31 120.0 COG1960@1|root,COG1960@2|Bacteria,2GKQI@201174|Actinobacteria,4CPEP@84995|Rubrobacteria 84995|Rubrobacteria I Acyl-CoA dehydrogenase, C-terminal domain - - 1.3.8.7 ko:K00249 ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320 M00013,M00036,M00087 R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754 RC00052,RC00068,RC00076,RC00095,RC00148,RC00246 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_1424319_2 1469613.JT55_07905 8.52e-36 130.0 COG1024@1|root,COG1024@2|Bacteria,1Q51H@1224|Proteobacteria,2TUPH@28211|Alphaproteobacteria 28211|Alphaproteobacteria I enoyl-CoA hydratase isomerase - - 4.2.1.17 ko:K01692 ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212 M00032,M00087 R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093 RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 - - - ECH_1 k59_125626_1 1177154.Y5S_01511 3.23e-30 124.0 COG1185@1|root,COG1185@2|Bacteria,1MVB9@1224|Proteobacteria,1RNBF@1236|Gammaproteobacteria,1XHJZ@135619|Oceanospirillales 135619|Oceanospirillales J Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction pnp - 2.7.7.8 ko:K00962 ko00230,ko00240,ko03018,map00230,map00240,map03018 M00394 R00437,R00438,R00439,R00440 RC02795 ko00000,ko00001,ko00002,ko01000,ko03016,ko03019 - - - KH_1,PNPase,RNase_PH,RNase_PH_C,S1 k59_1538053_1 869210.Marky_0739 1.65e-98 296.0 COG0451@1|root,COG0451@2|Bacteria,1WMCY@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus M PFAM NAD dependent epimerase dehydratase family - - - - - - - - - - - - Epimerase k59_1594142_2 983545.Glaag_1279 4.76e-51 177.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,4647X@72275|Alteromonadaceae 1236|Gammaproteobacteria T COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains fleR - - ko:K10943 ko02020,ko05111,map02020,map05111 M00515 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_972021_2 279714.FuraDRAFT_2777 1.34e-44 155.0 COG4266@1|root,COG4266@2|Bacteria,1MXJK@1224|Proteobacteria,2VKRI@28216|Betaproteobacteria,2KSTV@206351|Neisseriales 206351|Neisseriales F Allantoicase repeat alc - 3.5.3.4 ko:K01477 ko00230,ko01100,ko01120,map00230,map01100,map01120 M00546 R02422 RC00379,RC00712 ko00000,ko00001,ko00002,ko01000 - - - Allantoicase k59_1198713_2 419665.Maeo_0252 9.61e-08 54.7 COG0589@1|root,arCOG02053@2157|Archaea,2XX8Y@28890|Euryarchaeota,23QW3@183939|Methanococci 183939|Methanococci T PFAM UspA domain protein - - - - - - - - - - - - Usp k59_12678_2 1033730.CAHG01000005_gene952 9.88e-45 159.0 COG1623@1|root,COG1623@2|Bacteria,2GJ41@201174|Actinobacteria,4DNMZ@85009|Propionibacteriales 201174|Actinobacteria L Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP likely acts as a signaling molecule that may couple DNA integrity with a cellular process disA - 2.7.7.85 ko:K07067 - - - - ko00000,ko01000 - - - DisA-linker,DisA_N,HHH,HHH_2 k59_916164_1 525368.HMPREF0591_4529 4.17e-69 223.0 COG4638@1|root,COG4638@2|Bacteria,2GKJY@201174|Actinobacteria,236RV@1762|Mycobacteriaceae 201174|Actinobacteria P Rieske 2Fe-2S - - - - - - - - - - - - Rieske,Ring_hydroxyl_A k59_351883_2 397288.C806_01808 1.22e-19 84.3 COG3436@1|root,COG3436@2|Bacteria,1V7U9@1239|Firmicutes,24K4W@186801|Clostridia,27P7R@186928|unclassified Lachnospiraceae 186801|Clostridia L IS66 Orf2 like protein - - - ko:K07484 - - - - ko00000 - - - TnpB_IS66 k59_633595_1 1122137.AQXF01000001_gene2910 6.53e-181 524.0 COG2812@1|root,COG2812@2|Bacteria,1MVCK@1224|Proteobacteria,2TRPB@28211|Alphaproteobacteria 28211|Alphaproteobacteria L DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity dnaX - 2.7.7.7 ko:K02343 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_delta2,DNA_pol3_gamma3,DUF3646 k59_633595_2 1122137.AQXF01000001_gene2909 2.12e-29 107.0 COG0718@1|root,COG0718@2|Bacteria,1RGZD@1224|Proteobacteria,2UBQB@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection ybaB - - ko:K09747 - - - - ko00000 - - - YbaB_DNA_bd k59_1255189_2 240302.BN982_00499 3.07e-30 131.0 COG1193@1|root,COG1193@2|Bacteria,1TP5W@1239|Firmicutes,4H9NZ@91061|Bacilli,3ND8B@45667|Halobacillus 91061|Bacilli L Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity mutS2 GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - ko:K07456 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - MutS_V,Smr k59_916176_1 1123023.JIAI01000020_gene2136 2.72e-14 73.9 COG1028@1|root,COG1028@2|Bacteria,2GJU1@201174|Actinobacteria,4E4PW@85010|Pseudonocardiales 201174|Actinobacteria IQ Enoyl-(Acyl carrier protein) reductase butA - 1.1.1.100,1.1.1.304,1.1.1.76 ko:K00059,ko:K03366 ko00061,ko00333,ko00650,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00650,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R02855,R02946,R03707,R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R09078,R10116,R10120,R10505,R11671 RC00029,RC00117,RC00205,RC00525 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short,adh_short_C2 k59_860724_1 247634.GPB2148_738 5.85e-80 254.0 COG0696@1|root,COG0696@2|Bacteria,1MUQ1@1224|Proteobacteria,1RMJE@1236|Gammaproteobacteria,1J4GC@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria G Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate gpmI GO:0003674,GO:0003824,GO:0004619,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016866,GO:0016868,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0030145,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046537,GO:0046700,GO:0046872,GO:0046914,GO:0046939,GO:0050896,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576 5.4.2.12 ko:K15633 ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003 R01518 RC00536 ko00000,ko00001,ko00002,ko01000 - - iECSE_1348.ECSE_3895,iJN746.PP_5056 Metalloenzyme,Phosphodiest,iPGM_N k59_520292_1 1397527.Q670_15690 8.19e-29 108.0 COG1490@1|root,COG1490@2|Bacteria,1RGTV@1224|Proteobacteria,1S61I@1236|Gammaproteobacteria,1XK1V@135619|Oceanospirillales 135619|Oceanospirillales J rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality dtd - - ko:K07560 - - - - ko00000,ko01000,ko03016 - - - Tyr_Deacylase k59_520292_2 979556.MTES_1485 3.87e-11 65.1 COG2035@1|root,COG2035@2|Bacteria,2I8HU@201174|Actinobacteria,4FN4C@85023|Microbacteriaceae 201174|Actinobacteria S Domain of unknown function (DUF368) - - - ko:K08974 - - - - ko00000 - - - DUF368 k59_1085444_1 1123400.KB904752_gene853 7.17e-105 322.0 COG1032@1|root,COG1032@2|Bacteria,1QE05@1224|Proteobacteria,1RYZT@1236|Gammaproteobacteria,461MU@72273|Thiotrichales 72273|Thiotrichales C Elongator protein 3, MiaB family, Radical SAM - - - - - - - - - - - - Radical_SAM k59_125648_1 215803.DB30_8752 1.15e-30 126.0 COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,4346X@68525|delta/epsilon subdivisions,2XA3R@28221|Deltaproteobacteria,2YXWE@29|Myxococcales 28221|Deltaproteobacteria KLT Protein kinase domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase k59_1198736_1 247639.MGP2080_15654 1.04e-102 300.0 COG0723@1|root,COG0723@2|Bacteria,1RAA2@1224|Proteobacteria,1RP9H@1236|Gammaproteobacteria,1J50E@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis petA - 1.10.2.2 ko:K00411 ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016 M00151,M00152 - - ko00000,ko00001,ko00002,ko01000 - - - Rieske,UCR_Fe-S_N k59_1198736_2 876044.IMCC3088_1364 8.74e-14 69.7 COG1290@1|root,COG2857@1|root,COG1290@2|Bacteria,COG2857@2|Bacteria,1MV97@1224|Proteobacteria,1RNCP@1236|Gammaproteobacteria,1J5A4@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis petB - - ko:K00412 ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016 M00151,M00152 - - ko00000,ko00001,ko00002,ko03029 - - - Cytochrom_B_C,Cytochrom_C1,Cytochrome_B k59_238017_1 521393.JH806633_gene1237 3.44e-08 60.5 COG0515@1|root,COG0515@2|Bacteria,2GM6E@201174|Actinobacteria,4D33C@85005|Actinomycetales 201174|Actinobacteria KLT Kinase domain protein - - 2.7.11.1 ko:K08884,ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase k59_1650931_1 477974.Daud_0615 2.34e-07 52.0 COG0743@1|root,COG0743@2|Bacteria,1TP1C@1239|Firmicutes,2483M@186801|Clostridia,260S5@186807|Peptococcaceae 186801|Clostridia I Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) dxr - 1.1.1.267 ko:K00099 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05688 RC01452 ko00000,ko00001,ko00002,ko01000 - - iHN637.CLJU_RS06420 DXPR_C,DXP_redisom_C,DXP_reductoisom k59_1650931_2 991.IW20_13180 5.92e-26 108.0 COG4589@1|root,COG4589@2|Bacteria,4NIPM@976|Bacteroidetes,1HXPT@117743|Flavobacteriia,2NS7C@237|Flavobacterium 976|Bacteroidetes S Phosphatidate cytidylyltransferase cdsA - 2.7.7.41 ko:K00981 ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070 M00093 R01799 RC00002 ko00000,ko00001,ko00002,ko01000 - - - CTP_transf_1 k59_1482157_1 926566.Terro_0705 2.81e-52 192.0 COG0323@1|root,COG0323@2|Bacteria,3Y2T3@57723|Acidobacteria,2JI29@204432|Acidobacteriia 204432|Acidobacteriia L This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex mutL - - ko:K03572 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - DNA_mis_repair,HATPase_c_3,MutL_C k59_1030233_1 1123261.AXDW01000008_gene935 8.04e-41 150.0 COG1020@1|root,COG1020@2|Bacteria,1N7HY@1224|Proteobacteria,1RQJX@1236|Gammaproteobacteria,1X5I7@135614|Xanthomonadales 135614|Xanthomonadales Q Protein of unknown function (DUF1298) - - - - - - - - - - - - DUF1298,WES_acyltransf k59_746427_1 1122137.AQXF01000003_gene1880 1.07e-173 503.0 COG0021@1|root,COG0021@2|Bacteria,1MUEY@1224|Proteobacteria,2TQUX@28211|Alphaproteobacteria 28211|Alphaproteobacteria G Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate cbbT - 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 - - - Transket_pyr,Transketolase_C,Transketolase_N k59_1255213_1 1123037.AUDE01000004_gene35 1.9e-71 224.0 COG1682@1|root,COG1682@2|Bacteria,4NF36@976|Bacteroidetes,1HYJI@117743|Flavobacteriia 976|Bacteroidetes GM Transport permease protein - - - ko:K09690 ko02010,map02010 M00250 - - ko00000,ko00001,ko00002,ko02000 3.A.1.103 - - ABC2_membrane k59_633623_1 323848.Nmul_A0670 5.61e-91 291.0 COG0249@1|root,COG0249@2|Bacteria,1MUGX@1224|Proteobacteria,2VI3Z@28216|Betaproteobacteria,3729D@32003|Nitrosomonadales 28216|Betaproteobacteria L that it carries out the mismatch recognition step. This protein has a weak ATPase activity mutS - - ko:K03555 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V k59_351928_1 1123508.JH636446_gene6149 0.000183 50.1 COG5283@1|root,COG5283@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - PhageMin_Tail k59_1650945_1 436308.Nmar_0726 3.68e-189 538.0 COG0553@1|root,arCOG00883@2157|Archaea,41T0G@651137|Thaumarchaeota 651137|Thaumarchaeota K SNF2 family N-terminal domain - - - - - - - - - - - - Helicase_C,SNF2_N k59_1424401_1 309801.trd_A0363 1.26e-07 58.2 COG0477@1|root,COG2814@2|Bacteria,2G6D7@200795|Chloroflexi,27YUW@189775|Thermomicrobia 189775|Thermomicrobia EGP Major facilitator superfamily MFS_1 - - - - - - - - - - - - MFS_3 k59_1424401_2 575540.Isop_3662 1.01e-09 63.2 COG1102@1|root,COG1102@2|Bacteria,2J0M2@203682|Planctomycetes 203682|Planctomycetes F Cytidylate kinase-like family - - 2.7.4.25 ko:K00945 ko00240,ko01100,map00240,map01100 M00052 R00158,R00512,R01665 RC00002 ko00000,ko00001,ko00002,ko01000 - - - Cytidylate_kin2 k59_125686_1 1122137.AQXF01000005_gene1358 1.72e-172 511.0 COG1629@1|root,COG1629@2|Bacteria,1MX4K@1224|Proteobacteria,2TV3K@28211|Alphaproteobacteria 28211|Alphaproteobacteria P COG1629 Outer membrane receptor proteins, mostly Fe transport - - - - - - - - - - - - Plug,TonB_dep_Rec k59_916237_1 1122137.AQXF01000005_gene1113 1.7e-86 265.0 COG1533@1|root,COG1533@2|Bacteria,1MW0H@1224|Proteobacteria,2TQQB@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Radical SAM MA20_42330 - - - - - - - - - - - Radical_SAM k59_1030263_1 439375.Oant_3441 3.94e-25 109.0 COG0438@1|root,COG1216@1|root,COG0438@2|Bacteria,COG1216@2|Bacteria,1R7EX@1224|Proteobacteria,2U30Z@28211|Alphaproteobacteria,1J3Y9@118882|Brucellaceae 28211|Alphaproteobacteria M Glycosyltransferase Family 4 wgaB - - - - - - - - - - - Glyco_tranf_2_3,Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1,Glycos_transf_2 k59_577389_2 395493.BegalDRAFT_3538 2.68e-43 154.0 COG0162@1|root,COG0162@2|Bacteria,1MVUQ@1224|Proteobacteria,1RPKC@1236|Gammaproteobacteria,45ZVT@72273|Thiotrichales 72273|Thiotrichales J Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) tyrS - 6.1.1.1 ko:K01866 ko00970,map00970 M00359,M00360 R02918 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - S4,tRNA-synt_1b k59_972087_1 1304883.KI912532_gene35 1.12e-19 85.1 COG2913@1|root,COG2913@2|Bacteria,1N6YW@1224|Proteobacteria,2VRC6@28216|Betaproteobacteria,2KX54@206389|Rhodocyclales 206389|Rhodocyclales M Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane bamE - - ko:K06186 - - - - ko00000,ko02000 1.B.33.1 - - SmpA_OmlA k59_972087_2 395493.BegalDRAFT_3511 2.18e-09 56.6 COG0735@1|root,COG0735@2|Bacteria,1RDWJ@1224|Proteobacteria,1S4H7@1236|Gammaproteobacteria,460PC@72273|Thiotrichales 72273|Thiotrichales K Belongs to the Fur family fur - - ko:K03711 - - - - ko00000,ko03000 - - - FUR k59_1198775_1 1123354.AUDR01000015_gene261 1.07e-44 154.0 COG4105@1|root,COG4105@2|Bacteria,1MVS5@1224|Proteobacteria,2VH6I@28216|Betaproteobacteria,1KREX@119069|Hydrogenophilales 119069|Hydrogenophilales M Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane bamD - - ko:K05807 - - - - ko00000,ko02000 1.B.33.1 - - YfiO k59_295478_1 745718.JADT01000001_gene1627 5.91e-64 212.0 28JC9@1|root,2Z96Z@2|Bacteria,4NH48@976|Bacteroidetes,1HYRM@117743|Flavobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_295484_1 1221522.B723_09955 1.91e-10 66.6 COG4773@1|root,COG4773@2|Bacteria,1MW5E@1224|Proteobacteria,1RMBD@1236|Gammaproteobacteria 1236|Gammaproteobacteria P receptor - - - ko:K16088 - - - - ko00000,ko02000 1.B.14.1.10,1.B.14.1.3,1.B.14.1.8 - - Plug,STN,TonB_dep_Rec k59_126900_2 1229909.NSED_00035 7.8e-59 187.0 COG0518@1|root,arCOG00087@2157|Archaea,41SQR@651137|Thaumarchaeota 651137|Thaumarchaeota F glutamine amidotransferase - - 6.3.5.2 ko:K01951 ko00230,ko00983,ko01100,map00230,map00983,map01100 M00050 R01230,R01231,R08244 RC00010,RC00204 ko00000,ko00001,ko00002,ko01000,ko01002 - - - GATase k59_408928_1 1122137.AQXF01000002_gene588 3.03e-94 303.0 COG2366@1|root,COG2366@2|Bacteria,1MVMH@1224|Proteobacteria,2TS4D@28211|Alphaproteobacteria 28211|Alphaproteobacteria E COG2366 Protein related to penicillin acylase quiP - 3.5.1.11 ko:K01434 ko00311,ko01130,map00311,map01130 - R02170 RC00166,RC00328 ko00000,ko00001,ko01000,ko01002 - - - Penicil_amidase k59_408928_2 1122137.AQXF01000002_gene589 5.18e-59 191.0 COG1360@1|root,COG1360@2|Bacteria,1MW1Y@1224|Proteobacteria,2TTW2@28211|Alphaproteobacteria 28211|Alphaproteobacteria N flagellar motor protein motB - - ko:K02557 ko02030,ko02040,map02030,map02040 - - - ko00000,ko00001,ko02000,ko02035 1.A.30.1 - - MotB_plug,OmpA k59_1425553_1 1453501.JELR01000001_gene2392 1.93e-66 222.0 COG3291@1|root,COG3291@2|Bacteria,1QU15@1224|Proteobacteria,1T1KN@1236|Gammaproteobacteria,46D2W@72275|Alteromonadaceae 1236|Gammaproteobacteria S Pkd domain containing protein - - - - - - - - - - - - - k59_1425553_2 87626.PTD2_01826 2.25e-40 152.0 COG1629@1|root,COG1629@2|Bacteria,1MX4K@1224|Proteobacteria,1RP6B@1236|Gammaproteobacteria,2PZEF@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria P COG1629 Outer membrane receptor proteins, mostly Fe transport - - - - - - - - - - - - Plug,TonB_dep_Rec k59_756020_3 1122137.AQXF01000002_gene151 3.76e-137 394.0 COG0134@1|root,COG0134@2|Bacteria,1MW5K@1224|Proteobacteria,2TSZE@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Belongs to the TrpC family trpC GO:0003674,GO:0003824,GO:0004425,GO:0016829,GO:0016830,GO:0016831 4.1.1.48,5.3.1.24 ko:K01609,ko:K13498 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R03508,R03509 RC00944,RC00945 ko00000,ko00001,ko00002,ko01000 - - - IGPS k59_756020_4 861208.AGROH133_06571 1.5e-09 59.7 COG0547@1|root,COG0547@2|Bacteria,1MUPV@1224|Proteobacteria,2TR8S@28211|Alphaproteobacteria,4B71E@82115|Rhizobiaceae 28211|Alphaproteobacteria F Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) trpD GO:0000162,GO:0003674,GO:0003824,GO:0004048,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.18,4.1.3.27 ko:K00766,ko:K13497 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R00985,R00986,R01073 RC00010,RC00440,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 - - - Glycos_trans_3N,Glycos_transf_3 k59_1433871_1 1379281.AVAG01000035_gene1779 4.54e-77 237.0 COG0479@1|root,COG0479@2|Bacteria,1MVHS@1224|Proteobacteria,42M2J@68525|delta/epsilon subdivisions,2WJMH@28221|Deltaproteobacteria,2M84J@213115|Desulfovibrionales 28221|Deltaproteobacteria C TIGRFAM succinate dehydrogenase and fumarate reductase iron-sulfur protein sdhB - 1.3.5.1,1.3.5.4 ko:K00240,ko:K00245 ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020 M00009,M00011,M00149,M00150,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 - - - Fer2_3,Fer4_10,Fer4_8 k59_756030_1 479434.Sthe_1560 8.83e-23 93.6 COG0816@1|root,COG0816@2|Bacteria,2G74F@200795|Chloroflexi,27YI8@189775|Thermomicrobia 189775|Thermomicrobia L Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA - - - ko:K07447 - - - - ko00000,ko01000 - - - RuvX k59_305917_1 436308.Nmar_1021 3.58e-28 106.0 arCOG08738@1|root,arCOG08738@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - SHOCT k59_305917_2 436308.Nmar_1022 5.76e-35 123.0 COG1917@1|root,arCOG03444@2157|Archaea,41SV4@651137|Thaumarchaeota 651137|Thaumarchaeota S Cupin - - - - - - - - - - - - Cupin_2 k59_135861_1 1229909.NSED_06965 1.03e-35 130.0 arCOG08777@1|root,arCOG10350@1|root,arCOG08777@2157|Archaea,arCOG10350@2157|Archaea 2157|Archaea C sister chromatid segregation - - - - - - - - - - - - - k59_135861_2 436308.Nmar_1242 1.52e-15 74.3 COG1630@1|root,arCOG00367@2157|Archaea,41SJX@651137|Thaumarchaeota 651137|Thaumarchaeota L NurA - - - - - - - - - - - - NurA k59_1209076_1 1229909.NSED_01325 6.71e-125 375.0 COG1009@1|root,arCOG01539@2157|Archaea,41SC4@651137|Thaumarchaeota 651137|Thaumarchaeota C TIGRFAM proton-translocating NADH-quinone oxidoreductase, chain L - - 1.6.5.3 ko:K00341 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Proton_antipo_M,Proton_antipo_N k59_1209076_2 1229909.NSED_01330 1.85e-74 237.0 COG1007@1|root,arCOG01540@2157|Archaea,41SDU@651137|Thaumarchaeota 651137|Thaumarchaeota C NADH ubiquinone oxidoreductase subunit 2 (Chain N) - - 1.5.98.3 ko:K22169 - - - - ko00000,ko01000 3.D.9.1 - - Proton_antipo_M k59_1433887_1 1122214.AQWH01000008_gene1566 3.51e-30 124.0 COG1879@1|root,COG1879@2|Bacteria,1N1FF@1224|Proteobacteria,2UDI7@28211|Alphaproteobacteria 28211|Alphaproteobacteria G Periplasmic binding protein domain - - - ko:K10439 ko02010,ko02030,map02010,map02030 M00212 - - ko00000,ko00001,ko00002,ko02000 3.A.1.2.1,3.A.1.2.13,3.A.1.2.19 - - Peripla_BP_4 k59_1433887_2 1122939.ATUD01000001_gene696 0.000793 44.7 COG1172@1|root,COG1172@2|Bacteria,2GQDN@201174|Actinobacteria,4CS2M@84995|Rubrobacteria 84995|Rubrobacteria G Branched-chain amino acid transport system / permease component - - - ko:K10440 ko02010,map02010 M00212 - - ko00000,ko00001,ko00002,ko02000 3.A.1.2.1,3.A.1.2.13,3.A.1.2.19 - - BPD_transp_2 k59_1379171_1 903818.KI912268_gene2075 2.64e-17 80.9 COG0008@1|root,COG0008@2|Bacteria,3Y7DS@57723|Acidobacteria 57723|Acidobacteria J tRNA synthetases class I (E and Q), anti-codon binding domain - - 6.1.1.18 ko:K01886 ko00970,ko01100,map00970,map01100 M00359,M00360 R03652 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_1c,tRNA-synt_1c_C k59_135875_2 1313301.AUGC01000011_gene1150 1.88e-29 113.0 COG4276@1|root,COG4276@2|Bacteria,4NQJG@976|Bacteroidetes 976|Bacteroidetes S SRPBCC domain-containing protein - - - - - - - - - - - - Polyketide_cyc k59_1492367_1 555793.WSK_0969 5.54e-39 131.0 2AMM4@1|root,31CH4@2|Bacteria,1NASQ@1224|Proteobacteria,2UI4C@28211|Alphaproteobacteria,2K7B5@204457|Sphingomonadales 204457|Sphingomonadales - - - - - - - - - - - - - - - k59_1492367_2 1144305.PMI02_01535 4.38e-24 99.0 COG1171@1|root,COG1171@2|Bacteria,1MVWJ@1224|Proteobacteria,2TQN9@28211|Alphaproteobacteria,2K27R@204457|Sphingomonadales 204457|Sphingomonadales E Threonine dehydratase - - 4.3.1.19 ko:K01754 ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230 M00570 R00220,R00996 RC00418,RC02600 ko00000,ko00001,ko00002,ko01000 - - - PALP k59_700657_1 314285.KT71_12975 3.29e-33 125.0 COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,1RNAM@1236|Gammaproteobacteria,1J5GJ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria G Permease - - - - - - - - - - - - DctM k59_700657_2 1304275.C41B8_00975 2.34e-07 53.1 COG0451@1|root,COG0451@2|Bacteria,1MWVE@1224|Proteobacteria,1RR9D@1236|Gammaproteobacteria 1236|Gammaproteobacteria GM Dehydratase udh - 1.1.1.203 ko:K18981 ko00053,map00053 - R10841 RC00066 ko00000,ko00001,ko01000 - - - Epimerase k59_80329_1 1449351.RISW2_09820 2.63e-38 138.0 COG0725@1|root,COG0725@2|Bacteria,1NY9R@1224|Proteobacteria,2U095@28211|Alphaproteobacteria 28211|Alphaproteobacteria P Bacterial extracellular solute-binding protein - - - ko:K02020 ko02010,map02010 M00189 - - ko00000,ko00001,ko00002,ko02000 3.A.1.8 - - SBP_bac_11 k59_135882_1 1047013.AQSP01000130_gene1851 3.48e-22 101.0 COG1453@1|root,COG1453@2|Bacteria,2NNZZ@2323|unclassified Bacteria 2|Bacteria S Aldo/keto reductase family - - - ko:K07079 - - - - ko00000 - - - Aldo_ket_red,Fer4_17 k59_1492372_1 1122613.ATUP01000001_gene1427 3.7e-06 52.8 2EKD9@1|root,33E3J@2|Bacteria,1RIMW@1224|Proteobacteria,2UUAS@28211|Alphaproteobacteria,43YKC@69657|Hyphomonadaceae 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_1492372_2 57918.XP_004296708.1 5.31e-64 211.0 COG1741@1|root,2QQ5A@2759|Eukaryota,37REZ@33090|Viridiplantae,3G8XY@35493|Streptophyta,4JI8S@91835|fabids 35493|Streptophyta S Belongs to the pirin family - GO:0001101,GO:0003674,GO:0004857,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005829,GO:0005886,GO:0006950,GO:0006952,GO:0007154,GO:0007165,GO:0008150,GO:0009314,GO:0009416,GO:0009605,GO:0009607,GO:0009617,GO:0009628,GO:0009637,GO:0009719,GO:0009725,GO:0009737,GO:0009738,GO:0009755,GO:0009785,GO:0009892,GO:0009987,GO:0010033,GO:0010466,GO:0010605,GO:0016020,GO:0019222,GO:0023052,GO:0030162,GO:0030234,GO:0030414,GO:0030522,GO:0031323,GO:0031324,GO:0032268,GO:0032269,GO:0032870,GO:0033993,GO:0042221,GO:0042742,GO:0043086,GO:0043207,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044092,GO:0044424,GO:0044444,GO:0044464,GO:0045861,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0051336,GO:0051346,GO:0051704,GO:0051707,GO:0051716,GO:0052547,GO:0060255,GO:0061134,GO:0065007,GO:0065009,GO:0070887,GO:0071214,GO:0071215,GO:0071229,GO:0071310,GO:0071396,GO:0071478,GO:0071482,GO:0071483,GO:0071495,GO:0071944,GO:0080090,GO:0097305,GO:0097306,GO:0098542,GO:0098772,GO:0104004,GO:1901700,GO:1901701 - ko:K06911 - - - - ko00000 - - - Pirin,Pirin_C k59_1379189_1 4538.ORGLA04G0266200.1 6.89e-23 97.4 COG0494@1|root,2QSDR@2759|Eukaryota,389DA@33090|Viridiplantae,3GYFT@35493|Streptophyta,3M9C6@4447|Liliopsida,3IUBF@38820|Poales 35493|Streptophyta G NUDIX domain - - - - - - - - - - - - NUDIX k59_1379189_2 1121374.KB891587_gene2982 2.48e-44 155.0 COG5505@1|root,COG5505@2|Bacteria,1RAF4@1224|Proteobacteria,1S8PC@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Protein of unknown function (DUF819) - - - - - - - - - - - - DUF819 k59_248310_3 1157490.EL26_22655 6.71e-18 84.7 COG0640@1|root,COG0640@2|Bacteria,1TSRQ@1239|Firmicutes,4HBXM@91061|Bacilli,27A54@186823|Alicyclobacillaceae 91061|Bacilli K helix_turn_helix, Arsenical Resistance Operon Repressor - - - - - - - - - - - - HTH_20,HTH_5 k59_1095273_1 1229203.KI301992_gene1382 1.02e-07 55.1 COG1028@1|root,COG1028@2|Bacteria,2GIYQ@201174|Actinobacteria,3UXB4@52018|unclassified Actinobacteria (class) 201174|Actinobacteria IQ KR domain - - - - - - - - - - - - adh_short k59_1095273_2 1385520.N802_04425 1.17e-25 108.0 COG2907@1|root,COG2907@2|Bacteria,2GJMW@201174|Actinobacteria,4FEFE@85021|Intrasporangiaceae 201174|Actinobacteria S amine oxidase - - - - - - - - - - - - Amino_oxidase k59_925802_1 795666.MW7_2122 1.74e-46 166.0 COG0403@1|root,COG1003@1|root,COG0403@2|Bacteria,COG1003@2|Bacteria,1MUDP@1224|Proteobacteria,2VHQ6@28216|Betaproteobacteria,1K105@119060|Burkholderiaceae 28216|Betaproteobacteria E The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor gcvP - 1.4.4.2 ko:K00281 ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200 M00532 R01221,R03425 RC00022,RC00929,RC02834,RC02880 ko00000,ko00001,ko00002,ko01000 - - - GDC-P k59_925802_2 1121921.KB898707_gene875 2.01e-76 237.0 COG0012@1|root,COG0012@2|Bacteria,1MVM4@1224|Proteobacteria,1RMBI@1236|Gammaproteobacteria,2PN73@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria J Protein of unknown function (DUF933) ychF GO:0003674,GO:0003824,GO:0004857,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006950,GO:0006979,GO:0008150,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030234,GO:0043021,GO:0043022,GO:0043023,GO:0043086,GO:0044092,GO:0044424,GO:0044464,GO:0044877,GO:0050790,GO:0050896,GO:0065007,GO:0065009,GO:0098772 - ko:K06942 - - - - ko00000,ko03009 - - - MMR_HSR1,YchF-GTPase_C k59_981342_2 395493.BegalDRAFT_3319 1.7e-34 123.0 COG2922@1|root,COG2922@2|Bacteria,1RD5F@1224|Proteobacteria,1S43X@1236|Gammaproteobacteria,4612G@72273|Thiotrichales 72273|Thiotrichales S Belongs to the Smg family smg - - ko:K03747 - - - - ko00000 - - - DUF494 k59_1321554_1 37919.EP51_04240 4.18e-43 159.0 COG0513@1|root,COG0513@2|Bacteria,2GIUR@201174|Actinobacteria,4FUHN@85025|Nocardiaceae 201174|Actinobacteria L COG0513 Superfamily II DNA and RNA helicases - - - - - - - - - - - - DEAD,Helicase_C k59_1492389_2 2002.JOEQ01000021_gene6740 2.38e-33 129.0 COG1233@1|root,COG1233@2|Bacteria,2GMUC@201174|Actinobacteria,4EJI6@85012|Streptosporangiales 201174|Actinobacteria Q Flavin containing amine oxidoreductase - - - - - - - - - - - - Amino_oxidase,NAD_binding_8 k59_305972_1 1121033.AUCF01000027_gene2795 9.38e-26 104.0 COG0504@1|root,COG0504@2|Bacteria,1MUIT@1224|Proteobacteria,2TS4Y@28211|Alphaproteobacteria,2JPWM@204441|Rhodospirillales 204441|Rhodospirillales F Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates pyrG - 6.3.4.2 ko:K01937 ko00240,ko01100,map00240,map01100 M00052 R00571,R00573 RC00010,RC00074 ko00000,ko00001,ko00002,ko01000 - - - CTP_synth_N,GATase k59_1152277_1 316407.1736517 1.57e-91 274.0 COG0500@1|root,COG0500@2|Bacteria,1MVSK@1224|Proteobacteria,1RMQY@1236|Gammaproteobacteria,3XNSV@561|Escherichia 1236|Gammaproteobacteria J Catalyzes carboxymethyl transfer from carboxy-S- adenosyl-L-methionine (Cx-SAM) to 5-hydroxyuridine (ho5U) to form 5-carboxymethoxyuridine (cmo5U) at position 34 in tRNAs cmoB GO:0002097,GO:0002098,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016740,GO:0016741,GO:0016765,GO:0022607,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042802,GO:0043170,GO:0043412,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0065003,GO:0071704,GO:0071840,GO:0090304,GO:1901360 - ko:K15257 - - - - ko00000,ko01000,ko03016 - - - Methyltransf_9 k59_1152277_2 316407.1736516 8.9e-23 92.8 COG0500@1|root,COG2226@2|Bacteria,1MV4M@1224|Proteobacteria,1RMWY@1236|Gammaproteobacteria,3XPCC@561|Escherichia 1236|Gammaproteobacteria J Catalyzes the conversion of S-adenosyl-L-methionine (SAM) to carboxy-S-adenosyl-L-methionine (Cx-SAM) cmoA GO:0002097,GO:0002098,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360 - ko:K15256 - - - - ko00000,ko01000,ko03016 - - - Methyltransf_25 k59_1321559_1 314282.PCNPT3_06195 7.25e-56 192.0 COG0405@1|root,COG0405@2|Bacteria,1MUV6@1224|Proteobacteria,1RMIT@1236|Gammaproteobacteria,2QHVW@267894|Psychromonadaceae 1236|Gammaproteobacteria M Gamma-glutamyltranspeptidase ggt GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0006082,GO:0006508,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0008242,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016787,GO:0019538,GO:0019752,GO:0030288,GO:0030313,GO:0031975,GO:0034722,GO:0036374,GO:0042597,GO:0043094,GO:0043102,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0070011,GO:0071704,GO:0097264,GO:0140096,GO:1901564,GO:1901566,GO:1901576 2.3.2.2,3.4.19.13 ko:K00681 ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100 - R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935 RC00064,RC00090,RC00096 ko00000,ko00001,ko01000,ko01002 - - iAPECO1_1312.APECO1_3012,iECOK1_1307.ECOK1_3869,iECS88_1305.ECS88_3844,iECW_1372.ECW_m3706,iEKO11_1354.EKO11_0296,iETEC_1333.ETEC_3693,iUMN146_1321.UM146_17325,iUTI89_1310.UTI89_C3954,iWFL_1372.ECW_m3706 G_glu_transpept k59_1772773_1 68260.JOAY01000001_gene3898 6.46e-09 58.9 COG0654@1|root,COG0654@2|Bacteria,2GJG5@201174|Actinobacteria 201174|Actinobacteria CH monooxygenase, FAD-binding - - - - - - - - - - - - FAD_binding_3 k59_1772773_2 399795.CtesDRAFT_PD3475 2.94e-64 208.0 COG1028@1|root,COG1028@2|Bacteria,1MWGC@1224|Proteobacteria,2VNVP@28216|Betaproteobacteria,4AEK5@80864|Comamonadaceae 28216|Betaproteobacteria IQ KR domain - - - - - - - - - - - - adh_short_C2 k59_1772773_3 1207076.ALAT01000181_gene2223 2.32e-20 87.4 COG4122@1|root,COG4122@2|Bacteria,1N57D@1224|Proteobacteria,1S6JT@1236|Gammaproteobacteria 1236|Gammaproteobacteria S O-Methyltransferase - - - - - - - - - - - - Methyltransf_3 k59_981344_1 1229780.BN381_100196 3.23e-105 320.0 COG0766@1|root,COG0766@2|Bacteria,2GJPW@201174|Actinobacteria,3UWJ8@52018|unclassified Actinobacteria (class) 201174|Actinobacteria M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine murA - 2.5.1.7 ko:K00790 ko00520,ko00550,ko01100,map00520,map00550,map01100 - R00660 RC00350 ko00000,ko00001,ko01000,ko01011 - - - EPSP_synthase k59_248332_1 1037409.BJ6T_16260 1.59e-20 94.7 COG2984@1|root,COG2984@2|Bacteria,1MW5D@1224|Proteobacteria,2TSG1@28211|Alphaproteobacteria,3JUJ0@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S ABC transporter substrate binding protein - - - ko:K01989 - M00247 - - ko00000,ko00002,ko02000 - - - ABC_sub_bind k59_1492411_1 395493.BegalDRAFT_3140 1.5e-90 277.0 COG2873@1|root,COG2873@2|Bacteria,1NQME@1224|Proteobacteria,1T1GA@1236|Gammaproteobacteria,4602W@72273|Thiotrichales 72273|Thiotrichales E Cys/Met metabolism PLP-dependent enzyme - - 2.5.1.49 ko:K01740 ko00270,ko01100,map00270,map01100 - R01287,R04859 RC00020,RC02821,RC02848 ko00000,ko00001,ko01000 - - - Cys_Met_Meta_PP k59_305984_2 1122137.AQXF01000006_gene694 4.86e-202 567.0 COG1706@1|root,COG1706@2|Bacteria,1MVKW@1224|Proteobacteria,2TQNX@28211|Alphaproteobacteria 28211|Alphaproteobacteria N Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation flgI GO:0005575,GO:0005623,GO:0009288,GO:0009425,GO:0042597,GO:0042995,GO:0043226,GO:0043228,GO:0044422,GO:0044461,GO:0044463,GO:0044464 - ko:K02394 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - FlgI k59_1717619_1 869213.JCM21142_31000 1.4e-07 52.0 COG0205@1|root,COG0205@2|Bacteria,4NFPT@976|Bacteroidetes 976|Bacteroidetes G Phosphofructokinase - - 2.7.1.11,2.7.1.90 ko:K21071 ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130 - R00756,R00764,R02073,R03236,R04779 RC00002,RC00017 ko00000,ko00001,ko01000 - - - PFK k59_1042315_1 331869.BAL199_19798 2.03e-100 311.0 COG0659@1|root,COG0659@2|Bacteria,1MVWV@1224|Proteobacteria,2TUH6@28211|Alphaproteobacteria,4BPPB@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria P Sulfate permease family sulP - - ko:K03321 - - - - ko00000,ko02000 2.A.53.3 - - STAS,Sulfate_transp k59_1042315_2 1122137.AQXF01000006_gene900 5.03e-200 561.0 COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,2TQKE@28211|Alphaproteobacteria 28211|Alphaproteobacteria I acyl-CoA dehydrogenase - - - ko:K06446 ko00930,ko01100,ko01120,map00930,map01100,map01120 - R06943 RC00052 ko00000,ko00001,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_249672_1 1075090.GOAMR_59_00440 4.98e-41 155.0 COG0474@1|root,COG0474@2|Bacteria,2GJJC@201174|Actinobacteria,4GCPV@85026|Gordoniaceae 201174|Actinobacteria P Cation transporter/ATPase, N-terminus - - 3.6.3.8 ko:K01537 - - - - ko00000,ko01000 3.A.3.2 - - Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3 k59_307368_1 460265.Mnod_2637 3e-91 278.0 2DT9W@1|root,32UUT@2|Bacteria,1NV5H@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_1380625_1 86106.I862_01930 1.47e-65 209.0 COG2801@1|root,COG2801@2|Bacteria,1MVN5@1224|Proteobacteria,2TQK0@28211|Alphaproteobacteria,47FYM@766|Rickettsiales 28211|Alphaproteobacteria L HTH-like domain - - - - - - - - - - - - HTH_21,rve_3 k59_1380625_2 1198114.AciX9_2245 7.4e-11 60.8 COG2963@1|root,COG2963@2|Bacteria,3Y86J@57723|Acidobacteria,2JN6K@204432|Acidobacteriia 204432|Acidobacteriia L Transposase - - - - - - - - - - - - HTH_Tnp_1 k59_1096428_1 1122137.AQXF01000002_gene19 2.87e-85 271.0 COG5373@1|root,COG5373@2|Bacteria 2|Bacteria KLT membrane - - 2.7.7.7,3.4.21.10 ko:K01317,ko:K02343,ko:K02666 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko01002,ko02035,ko02044,ko03032,ko03400,ko04131 3.A.15.2 - - FecR,LptC,NLPC_P60,Pkinase,SH3_3 k59_1042325_1 326298.Suden_1006 0.000178 48.9 COG1629@1|root,COG4771@2|Bacteria,1MUC1@1224|Proteobacteria,42NGM@68525|delta/epsilon subdivisions,2YN51@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P receptor - - - ko:K02014,ko:K16089 - - - - ko00000,ko02000 1.B.14,1.B.14.1,1.B.14.10 - - Plug,TonB_dep_Rec k59_1210581_1 983545.Glaag_3751 1.11e-66 228.0 COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,1MU7B@1224|Proteobacteria,1RN2W@1236|Gammaproteobacteria,465BS@72275|Alteromonadaceae 1236|Gammaproteobacteria E COG0067 Glutamate synthase domain 1 gltB GO:0003674,GO:0003824,GO:0004355,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006541,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0015930,GO:0016053,GO:0016491,GO:0016638,GO:0016639,GO:0019676,GO:0019740,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045181,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.4.1.13,1.4.1.14 ko:K00265 ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 - R00093,R00114,R00248 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - iBWG_1329.BWG_2914,iECDH10B_1368.ECDH10B_3387,iECDH1ME8569_1439.EcDH1_0495,iEcDH1_1363.EcDH1_0495,iPC815.YPO3557 GATase_2,GXGXG,Glu_syn_central,Glu_synthase k59_1153516_1 335659.S23_11060 5.47e-13 68.6 COG3616@1|root,COG3616@2|Bacteria,1MVQE@1224|Proteobacteria,2TSQ3@28211|Alphaproteobacteria,3JSXI@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria E Putative serine dehydratase domain dhaa - 4.1.3.41 ko:K18425 - - - - ko00000,ko01000 - - - Ala_racemase_N,D-ser_dehydrat k59_1153516_2 375286.mma_0820 2.48e-48 157.0 COG1917@1|root,COG1917@2|Bacteria,1MYMN@1224|Proteobacteria 1224|Proteobacteria S AraC-like ligand binding domain - - - - - - - - - - - - Cupin_2 k59_1265233_1 391587.KAOT1_08759 2.1e-135 395.0 COG0621@1|root,COG0621@2|Bacteria,4NE0R@976|Bacteroidetes,1HWYI@117743|Flavobacteriia 976|Bacteroidetes J 2-methylthioadenine synthetase yqeV - 2.8.4.5 ko:K18707 - - R10649 RC00003,RC03221 ko00000,ko01000,ko03016 - - - Radical_SAM,UPF0004 k59_1322559_1 478741.JAFS01000002_gene969 2.85e-10 61.6 COG3748@1|root,COG3748@2|Bacteria,46VDW@74201|Verrucomicrobia,37H8Y@326457|unclassified Verrucomicrobia 74201|Verrucomicrobia S Urate oxidase N-terminal - - - - - - - - - - - - Urate_ox_N k59_1322559_2 1121033.AUCF01000008_gene5710 8.15e-173 487.0 COG0726@1|root,COG0726@2|Bacteria,1MV3V@1224|Proteobacteria,2TR0I@28211|Alphaproteobacteria,2JQCA@204441|Rhodospirillales 204441|Rhodospirillales G Polysaccharide deacetylase - - 3.5.1.41 ko:K01452 ko00520,ko01100,map00520,map01100 - R02333 RC00166,RC00300 ko00000,ko00001,ko01000 - - - Polysacc_deac_1 k59_1322559_3 1121033.AUCF01000038_gene616 1.57e-41 143.0 COG3195@1|root,COG3195@2|Bacteria,1RH9S@1224|Proteobacteria,2U9Y5@28211|Alphaproteobacteria,2JZBN@204441|Rhodospirillales 204441|Rhodospirillales S OHCU decarboxylase - - - - - - - - - - - - OHCU_decarbox k59_1322559_4 314231.FP2506_17769 1.45e-29 114.0 COG4266@1|root,COG4266@2|Bacteria,1MXJK@1224|Proteobacteria,2TSZB@28211|Alphaproteobacteria,2PKAI@255475|Aurantimonadaceae 28211|Alphaproteobacteria F Allantoicase repeat alc - 3.5.3.4 ko:K01477 ko00230,ko01100,ko01120,map00230,map01100,map01120 M00546 R02422 RC00379,RC00712 ko00000,ko00001,ko00002,ko01000 - - - Allantoicase k59_872598_1 471854.Dfer_5639 2.36e-110 322.0 COG1131@1|root,COG1131@2|Bacteria,4NFW9@976|Bacteroidetes,47MY4@768503|Cytophagia 976|Bacteroidetes V AAA domain, putative AbiEii toxin, Type IV TA system - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_1042338_1 1049564.TevJSym_an00080 1.14e-78 252.0 COG0471@1|root,COG0490@1|root,COG0471@2|Bacteria,COG0490@2|Bacteria,1MU0K@1224|Proteobacteria,1RMI1@1236|Gammaproteobacteria,1J4XJ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P COG0471 Di- and tricarboxylate transporters - - - - - - - - - - - - CitMHS,TrkA_C k59_192899_1 314285.KT71_13350 1.8e-50 175.0 COG3004@1|root,COG3004@2|Bacteria,1MW15@1224|Proteobacteria,1RNDE@1236|Gammaproteobacteria,1J5GM@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P Na( ) H( ) antiporter that extrudes sodium in exchange for external protons nhaA - - ko:K03313 - - - - ko00000,ko02000 2.A.33.1 - - Na_H_antiport_1,Thioredoxin_4 k59_81792_1 1040983.AXAE01000008_gene370 8.25e-147 423.0 COG3328@1|root,COG3328@2|Bacteria,1MU4P@1224|Proteobacteria,2TTAW@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Transposase - - - - - - - - - - - - Transposase_mut k59_1773645_1 1056820.KB900652_gene3248 2.02e-26 104.0 COG1416@1|root,COG1416@2|Bacteria,1NAV2@1224|Proteobacteria,1SXJ3@1236|Gammaproteobacteria,2PPIR@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_1773645_2 1415778.JQMM01000001_gene417 1.04e-39 133.0 COG0316@1|root,COG0316@2|Bacteria,1RHCW@1224|Proteobacteria,1S675@1236|Gammaproteobacteria,1J65U@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Iron-sulfur cluster insertion protein ErpA erpA GO:0003674,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006091,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009060,GO:0009061,GO:0009987,GO:0010467,GO:0015980,GO:0016043,GO:0016226,GO:0019538,GO:0022607,GO:0031163,GO:0043167,GO:0043169,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0046872,GO:0046914,GO:0048037,GO:0051186,GO:0051536,GO:0051537,GO:0051539,GO:0051540,GO:0051604,GO:0055114,GO:0071704,GO:0071840,GO:1901564 - ko:K15724 - - - - ko00000 - - - Fe-S_biosyn k59_364144_1 203122.Sde_3374 2.39e-70 236.0 COG0591@1|root,COG4191@1|root,COG0591@2|Bacteria,COG4191@2|Bacteria,1QTSW@1224|Proteobacteria,1T1G2@1236|Gammaproteobacteria,4643M@72275|Alteromonadaceae 1236|Gammaproteobacteria T COG0591 Na proline symporter cbrA - - - - - - - - - - - HATPase_c,HisKA,PAS k59_702182_1 1088721.NSU_4206 8.02e-97 297.0 COG0595@1|root,COG0595@2|Bacteria,1MUGV@1224|Proteobacteria,2TQTR@28211|Alphaproteobacteria,2K04C@204457|Sphingomonadales 204457|Sphingomonadales S metallo-beta-lactamase - - - ko:K12574 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - Lactamase_B,Lactamase_B_2,RMMBL k59_307425_1 519989.ECTPHS_07586 4.22e-81 263.0 COG0187@1|root,COG0187@2|Bacteria,1MVKT@1224|Proteobacteria,1RNB2@1236|Gammaproteobacteria,1WVZ4@135613|Chromatiales 135613|Chromatiales L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrB - 5.99.1.3 ko:K02470 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim k59_1380679_1 436308.Nmar_0275 7.62e-84 249.0 COG1225@1|root,arCOG00310@2157|Archaea,41SKG@651137|Thaumarchaeota 651137|Thaumarchaeota O Redoxin - - 1.11.1.15 ko:K03564 - - - - ko00000,ko01000 - - - AhpC-TSA k59_982448_1 1415778.JQMM01000001_gene1169 3.49e-38 128.0 COG0828@1|root,COG0828@2|Bacteria,1MZCC@1224|Proteobacteria,1S8QZ@1236|Gammaproteobacteria,1J6RF@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Belongs to the bacterial ribosomal protein bS21 family rpsU GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02970 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S21 k59_137405_2 1137281.D778_02667 4.09e-57 188.0 COG0457@1|root,COG2819@1|root,COG0457@2|Bacteria,COG2819@2|Bacteria,4NN8M@976|Bacteroidetes,1I1EI@117743|Flavobacteriia 976|Bacteroidetes NU hydrolase of the alpha beta superfamily - - - ko:K07017 - - - - ko00000 - - - Esterase k59_1158876_1 1292034.OR37_03538 1.71e-50 187.0 COG1506@1|root,COG1506@2|Bacteria,1MUJ3@1224|Proteobacteria,2TUZZ@28211|Alphaproteobacteria,2KFCI@204458|Caulobacterales 204458|Caulobacterales E Prolyl oligopeptidase - - - - - - - - - - - - Peptidase_S9 k59_255762_1 314607.KB13_1008 1.76e-08 54.3 2C1YJ@1|root,32ZXK@2|Bacteria,1N98H@1224|Proteobacteria,2VVT5@28216|Betaproteobacteria,1KR5E@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria S Protein of unknown function (DUF2782) - - - - - - - - - - - - DUF2782 k59_255762_2 1485544.JQKP01000002_gene1448 4.43e-31 117.0 COG2334@1|root,COG2334@2|Bacteria,1MUKJ@1224|Proteobacteria,2VH2I@28216|Betaproteobacteria,44V2D@713636|Nitrosomonadales 28216|Betaproteobacteria H Belongs to the pseudomonas-type ThrB family thrB - 2.7.1.39 ko:K02204 ko00260,ko01100,ko01110,ko01120,ko01230,map00260,map01100,map01110,map01120,map01230 M00018 R01771 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - APH k59_987009_1 247634.GPB2148_1148 5.72e-98 310.0 COG3383@1|root,COG3383@2|Bacteria,1QTZB@1224|Proteobacteria,1T1JA@1236|Gammaproteobacteria,1J9HS@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C NADH-ubiquinone oxidoreductase-G iron-sulfur binding region fdhF GO:0003674,GO:0003824,GO:0003954,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0008150,GO:0008152,GO:0009987,GO:0015942,GO:0015944,GO:0016491,GO:0016651,GO:0016999,GO:0017144,GO:0019752,GO:0030151,GO:0032787,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0071704 1.17.1.9,1.17.99.7 ko:K00123,ko:K22015 ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200 - R00519 RC02796 ko00000,ko00001,ko01000 - - iECBD_1354.ECBD_3953 Fer2_4,Fer4,Fer4_7,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3 k59_1216706_2 1120956.JHZK01000002_gene1019 8.49e-52 168.0 COG1917@1|root,COG1917@2|Bacteria,1MYMN@1224|Proteobacteria,2UR93@28211|Alphaproteobacteria 28211|Alphaproteobacteria S AraC-like ligand binding domain - - - - - - - - - - - - Cupin_2 k59_1216706_3 1120956.JHZK01000002_gene994 4.23e-95 291.0 COG1228@1|root,COG1228@2|Bacteria,1MVAF@1224|Proteobacteria,2TTYC@28211|Alphaproteobacteria,1JP94@119043|Rhodobiaceae 28211|Alphaproteobacteria Q Amidohydrolase family - - - - - - - - - - - - Amidohydro_1 k59_931226_1 1112216.JH594425_gene1179 4.97e-108 341.0 COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,2TRWM@28211|Alphaproteobacteria,2K1QB@204457|Sphingomonadales 204457|Sphingomonadales P AcrB/AcrD/AcrF family - - - ko:K15726 - - - - ko00000,ko02000 2.A.6.1.2 - - ACR_tran k59_1500189_1 1120970.AUBZ01000018_gene3334 6.52e-96 292.0 COG0161@1|root,COG0161@2|Bacteria,1MU2N@1224|Proteobacteria,1RNW9@1236|Gammaproteobacteria,469XH@72275|Alteromonadaceae 1236|Gammaproteobacteria E Aminotransferase class-III - - 2.6.1.77 ko:K03851 ko00430,ko01100,map00430,map01100 - R05652 RC00008,RC00062 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_3 k59_423565_1 1123073.KB899242_gene1157 3.19e-52 186.0 COG0457@1|root,COG0457@2|Bacteria,1N0A9@1224|Proteobacteria,1RZSZ@1236|Gammaproteobacteria,1X572@135614|Xanthomonadales 135614|Xanthomonadales S COG0457 FOG TPR repeat - - - - - - - - - - - - - k59_255768_2 1118054.CAGW01000085_gene4651 0.000132 48.1 COG1595@1|root,COG1595@2|Bacteria,1VAEY@1239|Firmicutes,4HMVP@91061|Bacilli,26Y52@186822|Paenibacillaceae 91061|Bacilli K Sigma-70, region 4 xpf - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r4_2 k59_1386967_1 467661.RKLH11_3570 1.04e-82 265.0 COG2274@1|root,COG2274@2|Bacteria,1R2T0@1224|Proteobacteria,2USBQ@28211|Alphaproteobacteria 28211|Alphaproteobacteria V COG2274 ABC-type bacteriocin lantibiotic exporters, contain an N-terminal double-glycine peptidase domain hlyB - - ko:K06147,ko:K11004 ko02010,ko03070,ko05133,map02010,map03070,map05133 M00325,M00575 - - ko00000,ko00001,ko00002,ko02000,ko02044 3.A.1.106,3.A.1.109,3.A.1.109.1,3.A.1.109.2,3.A.1.21 - - ABC_membrane,ABC_tran,Peptidase_C39 k59_88105_1 1123270.ATUR01000008_gene313 1.32e-13 70.1 COG1115@1|root,COG1115@2|Bacteria,1MUI3@1224|Proteobacteria,2TQVA@28211|Alphaproteobacteria,2K1FH@204457|Sphingomonadales 204457|Sphingomonadales U alanine symporter - - - ko:K03310 - - - - ko00000 2.A.25 - - Na_Ala_symp k59_708359_1 1122137.AQXF01000002_gene339 1.21e-130 412.0 COG3164@1|root,COG3164@2|Bacteria,1MVDY@1224|Proteobacteria,2TSGG@28211|Alphaproteobacteria 28211|Alphaproteobacteria M Protein of unknown function MA20_30770 - - - - - - - - - - - AsmA_2,DUF3971 k59_648882_1 1205753.A989_18025 6.37e-10 65.5 COG0643@1|root,COG0784@1|root,COG2198@1|root,COG0643@2|Bacteria,COG0784@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,1RMS6@1236|Gammaproteobacteria,1X3AY@135614|Xanthomonadales 135614|Xanthomonadales T Chemotaxis protein histidine kinase and related kinases pilL - - ko:K02487,ko:K06596 ko02020,ko02025,map02020,map02025 M00507 - - ko00000,ko00001,ko00002,ko01001,ko02022,ko02035 - - - CheW,H-kinase_dim,HATPase_c,Hpt,Response_reg k59_313729_1 1122137.AQXF01000006_gene854 3.02e-156 447.0 COG0156@1|root,COG0156@2|Bacteria,1MVVH@1224|Proteobacteria,2TQYP@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA bioF - 2.3.1.29,2.3.1.47,2.3.1.50 ko:K00639,ko:K00652,ko:K00654 ko00260,ko00600,ko00780,ko01100,ko04071,ko04138,map00260,map00600,map00780,map01100,map04071,map04138 M00094,M00099,M00123,M00573,M00577 R00371,R01281,R03210,R10124 RC00004,RC00039,RC00394,RC02725,RC02849 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 k59_1500204_1 246197.MXAN_1676 1e-91 290.0 COG0277@1|root,COG0277@2|Bacteria,1MXTV@1224|Proteobacteria,42RXR@68525|delta/epsilon subdivisions,2WNHV@28221|Deltaproteobacteria 28221|Deltaproteobacteria C PFAM FAD linked oxidase domain protein - - 2.5.1.26 ko:K00803 ko00565,ko01100,ko04146,map00565,map01100,map04146 - R04311 RC00020,RC02886 ko00000,ko00001,ko01000 - - - FAD-oxidase_C,FAD_binding_4 k59_1666838_2 1907.SGLAU_29085 0.000422 46.6 COG1404@1|root,COG1404@2|Bacteria,2GK3D@201174|Actinobacteria 201174|Actinobacteria O Belongs to the peptidase S8 family - - - - - - - - - - - - Inhibitor_I9,PA,PPC,Peptidase_S8 k59_313733_1 865937.Gilli_2988 6.6e-10 64.3 COG0500@1|root,COG2226@2|Bacteria,4NM32@976|Bacteroidetes,1I6PD@117743|Flavobacteriia,2P5DV@244698|Gillisia 976|Bacteroidetes Q Putative S-adenosyl-L-methionine-dependent methyltransferase - - - - - - - - - - - - Methyltransf_11,Methyltransf_31 k59_1326944_1 926569.ANT_00270 1.33e-102 311.0 COG0044@1|root,COG0044@2|Bacteria,2G5N4@200795|Chloroflexi 200795|Chloroflexi F Amidohydrolase family - - 3.5.2.2,3.5.2.5 ko:K01464,ko:K01466 ko00230,ko00240,ko00410,ko00770,ko00983,ko01100,ko01120,map00230,map00240,map00410,map00770,map00983,map01100,map01120 M00046,M00546 R02269,R02425,R03055,R08227 RC00632,RC00680 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Amidohydro_1 k59_818488_2 436308.Nmar_0225 1.02e-79 237.0 COG1358@1|root,arCOG01751@2157|Archaea,41SMS@651137|Thaumarchaeota 651137|Thaumarchaeota J Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H ACA, box C D and box C' D' sRNAs rpl7ae - - ko:K02936 ko03010,map03010 M00177,M00179 - - br01610,ko00000,ko00001,ko00002,ko03009,ko03011 - - - Ribosomal_L7Ae k59_1158908_1 1122194.AUHU01000001_gene3 7.49e-62 198.0 COG1349@1|root,COG1349@2|Bacteria,1QM4U@1224|Proteobacteria,1RNN2@1236|Gammaproteobacteria,465D2@72275|Alteromonadaceae 1236|Gammaproteobacteria K DeoR C terminal sensor domain ulaR GO:0003674,GO:0005488,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0019842,GO:0030246,GO:0031406,GO:0031418,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0048029,GO:0048037,GO:0050662,GO:0071704,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576 - ko:K03477 - - - - ko00000,ko03000 - - - DeoRC,HTH_DeoR k59_761450_1 207954.MED92_00665 7.78e-71 217.0 COG0219@1|root,COG0219@2|Bacteria,1RCY4@1224|Proteobacteria,1S3PI@1236|Gammaproteobacteria,1XJKM@135619|Oceanospirillales 135619|Oceanospirillales J Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide trmL - 2.1.1.207 ko:K03216 - - - - ko00000,ko01000,ko03016 - - - SpoU_methylase k59_761450_2 1415778.JQMM01000001_gene2144 6.4e-13 67.4 COG1814@1|root,COG1814@2|Bacteria,1MUZE@1224|Proteobacteria,1S2G7@1236|Gammaproteobacteria,1J61C@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S VIT family - - - - - - - - - - - - VIT1 k59_423581_1 1120705.FG95_00286 5.06e-07 57.4 COG0790@1|root,COG0790@2|Bacteria,1RJ71@1224|Proteobacteria,2U15P@28211|Alphaproteobacteria,2K032@204457|Sphingomonadales 204457|Sphingomonadales S FOG TPR repeat, SEL1 subfamily - - - ko:K07126 - - - - ko00000 - - - SPOR,Sel1 k59_423581_2 1415780.JPOG01000001_gene2435 5.84e-19 85.5 COG2836@1|root,COG2836@2|Bacteria,1RIGJ@1224|Proteobacteria,1S5V1@1236|Gammaproteobacteria,1X66I@135614|Xanthomonadales 135614|Xanthomonadales S Cytochrome C biogenesis protein transmembrane region - - - ko:K09792 - - - - ko00000 - - - DsbD_2 k59_30982_1 1096930.L284_04190 5.86e-109 329.0 COG4251@1|root,COG4251@2|Bacteria,1NSQ1@1224|Proteobacteria,2TSPY@28211|Alphaproteobacteria,2K9I0@204457|Sphingomonadales 204457|Sphingomonadales T PAS domain - - - - - - - - - - - - HATPase_c,HisKA,PAS,PAS_8,PAS_9 k59_479158_1 1484460.JSWG01000001_gene2213 5.52e-59 194.0 COG0477@1|root,COG2814@2|Bacteria,4NEUU@976|Bacteroidetes,1HX12@117743|Flavobacteriia 976|Bacteroidetes EGP major facilitator - - - - - - - - - - - - MFS_1,MFS_3 k59_479158_2 1046627.BZARG_2388 5.78e-05 44.7 COG3358@1|root,COG3358@2|Bacteria,4NNWJ@976|Bacteroidetes,1I20T@117743|Flavobacteriia 976|Bacteroidetes S Protein of unknown function (DUF1684) - - - ko:K09164 - - - - ko00000 - - - DUF1684 k59_595176_1 765420.OSCT_0344 5.61e-115 347.0 COG1274@1|root,COG1274@2|Bacteria,2G7VM@200795|Chloroflexi,374XU@32061|Chloroflexia 32061|Chloroflexia H Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle pckG - 4.1.1.32 ko:K01596 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko03320,ko04068,ko04151,ko04152,ko04910,ko04920,ko04922,ko04931,ko04964,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map03320,map04068,map04151,map04152,map04910,map04920,map04922,map04931,map04964 M00003 R00431,R00726 RC00002,RC02741 ko00000,ko00001,ko00002,ko01000 - - - PEPCK_C,PEPCK_N k59_1557100_1 1033991.RLEG12_20870 1.58e-12 65.1 COG2945@1|root,COG2945@2|Bacteria,1MUDY@1224|Proteobacteria,2TRMI@28211|Alphaproteobacteria,4B9KE@82115|Rhizobiaceae 28211|Alphaproteobacteria S hydrolase of the alpha beta superfamily QU41_16170 - - ko:K07018 - - - - ko00000 - - - Hydrolase_4,Peptidase_S15 k59_1557100_2 246437.XP_006152041.1 9.39e-15 77.0 COG1104@1|root,KOG1549@2759|Eukaryota,38ZIY@33154|Opisthokonta,3BH4M@33208|Metazoa,3CW5A@33213|Bilateria,47ZR3@7711|Chordata,492SR@7742|Vertebrata,3JF8H@40674|Mammalia,35HWY@314146|Euarchontoglires 33208|Metazoa E Selenocysteine lyase SCLY GO:0001887,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006629,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009000,GO:0009056,GO:0009063,GO:0009069,GO:0009071,GO:0009719,GO:0009725,GO:0009987,GO:0010033,GO:0010243,GO:0016054,GO:0016259,GO:0016261,GO:0016597,GO:0016829,GO:0016846,GO:0019752,GO:0019842,GO:0031406,GO:0032868,GO:0032991,GO:0036094,GO:0042221,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043177,GO:0043434,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0046983,GO:0048519,GO:0048523,GO:0048583,GO:0048585,GO:0050789,GO:0050794,GO:0050896,GO:0065007,GO:0070279,GO:0071704,GO:0080134,GO:0080135,GO:0097159,GO:1900407,GO:1900408,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606,GO:1901652,GO:1901698,GO:1901700,GO:1902494,GO:1902882,GO:1902883 4.4.1.16 ko:K01763 ko00450,ko01100,map00450,map01100 - R03599 RC00961 ko00000,ko00001,ko01000 - - - Aminotran_5 k59_1612222_1 436308.Nmar_0672 5.84e-95 285.0 COG0492@1|root,arCOG01296@2157|Archaea,41S97@651137|Thaumarchaeota 651137|Thaumarchaeota O Pyridine nucleotide-disulphide oxidoreductase - - 1.8.1.9 ko:K00384 ko00450,map00450 - R02016,R03596,R09372 RC00013,RC02518,RC02873 ko00000,ko00001,ko01000 - - - Pyr_redox_2 k59_1158930_1 395493.BegalDRAFT_2790 5.54e-115 343.0 COG0247@1|root,COG0247@2|Bacteria,1MWTK@1224|Proteobacteria,1RQ9M@1236|Gammaproteobacteria,4620M@72273|Thiotrichales 72273|Thiotrichales C Cysteine-rich domain - - - - - - - - - - - - CCG k59_1387014_1 698761.RTCIAT899_CH06280 2.64e-17 75.5 COG1977@1|root,COG1977@2|Bacteria,1N0IE@1224|Proteobacteria,2UF4F@28211|Alphaproteobacteria,4BG4H@82115|Rhizobiaceae 28211|Alphaproteobacteria H Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin moaD - - ko:K03636 ko04122,map04122 - - - ko00000,ko00001 - - - ThiS k59_1387014_2 1122137.AQXF01000003_gene2300 3.02e-93 275.0 COG0558@1|root,COG0558@2|Bacteria,1RCZ7@1224|Proteobacteria,2TUI7@28211|Alphaproteobacteria 28211|Alphaproteobacteria I Belongs to the CDP-alcohol phosphatidyltransferase class-I family pgsA - 2.7.8.41,2.7.8.5 ko:K00995,ko:K08744 ko00564,ko01100,map00564,map01100 - R01801,R02030 RC00002,RC00017,RC02795 ko00000,ko00001,ko01000 - - - CDP-OH_P_transf k59_1387014_3 1122137.AQXF01000003_gene2301 1.58e-206 587.0 COG0322@1|root,COG0322@2|Bacteria,1MV38@1224|Proteobacteria,2TT32@28211|Alphaproteobacteria 28211|Alphaproteobacteria L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision uvrC GO:0005575,GO:0005622,GO:0005623,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009380,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0032991,GO:0033554,GO:0044424,GO:0044464,GO:0050896,GO:0051716,GO:0071496,GO:1902494,GO:1905347,GO:1905348,GO:1990391 - ko:K03703 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - GIY-YIG,HHH_2,HHH_5,UVR,UvrC_HhH_N k59_31006_1 1537715.JQFJ01000002_gene1204 2.74e-107 328.0 COG0441@1|root,COG0441@2|Bacteria,1MUP2@1224|Proteobacteria,2TQWI@28211|Alphaproteobacteria,2K14B@204457|Sphingomonadales 204457|Sphingomonadales J Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) thrS - 6.1.1.3 ko:K01868 ko00970,map00970 M00359,M00360 R03663 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,TGS,tRNA-synt_2b,tRNA_SAD k59_1612230_1 469383.Cwoe_1001 1.04e-21 96.7 COG0300@1|root,COG0300@2|Bacteria,2IIVW@201174|Actinobacteria,4CT0F@84995|Rubrobacteria 84995|Rubrobacteria S Fungal family of unknown function (DUF1776) - - - - - - - - - - - - adh_short k59_818523_1 1122137.AQXF01000004_gene1397 1.44e-103 313.0 COG0128@1|root,COG0128@2|Bacteria,1MWMK@1224|Proteobacteria,2TR6W@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate aroA GO:0003674,GO:0003824,GO:0003866,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046417,GO:0071704,GO:1901576 2.5.1.19 ko:K00800 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R03460 RC00350 ko00000,ko00001,ko00002,ko01000 - - - EPSP_synthase k59_987061_2 1229909.NSED_04295 1.48e-29 111.0 arCOG08713@1|root,arCOG08713@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_1216780_1 713587.THITH_13710 2.6e-14 75.5 COG2885@1|root,COG2885@2|Bacteria,1P1AB@1224|Proteobacteria,1RMCQ@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Belongs to the ompA family oprF - - - - - - - - - - - OmpA k59_1158940_1 1122604.JONR01000033_gene45 1.38e-90 298.0 COG2114@1|root,COG3899@1|root,COG2114@2|Bacteria,COG3899@2|Bacteria,1MUDT@1224|Proteobacteria,1S0DF@1236|Gammaproteobacteria 1236|Gammaproteobacteria K AAA ATPase domain - - - - - - - - - - - - AAA_16,BTAD,Guanylate_cyc k59_1270194_1 158500.BV97_02611 3.55e-54 186.0 COG2182@1|root,COG2182@2|Bacteria,1MU3H@1224|Proteobacteria,2U0ZI@28211|Alphaproteobacteria,2K10P@204457|Sphingomonadales 204457|Sphingomonadales G Extracellular solute-binding protein - - - - - - - - - - - - - k59_257112_2 1453501.JELR01000002_gene639 1.02e-68 218.0 COG0384@1|root,COG0384@2|Bacteria,1MUAS@1224|Proteobacteria,1RPWM@1236|Gammaproteobacteria,467X3@72275|Alteromonadaceae 1236|Gammaproteobacteria S Phenazine biosynthesis-like protein - - 5.3.3.17 ko:K06998 ko00405,ko01130,ko02024,map00405,map01130,map02024 M00835 - - ko00000,ko00001,ko00002,ko01000 - - - PhzC-PhzF k59_1049366_1 1415778.JQMM01000001_gene866 6.16e-89 273.0 COG0772@1|root,COG0772@2|Bacteria,1MVDB@1224|Proteobacteria,1RMIV@1236|Gammaproteobacteria,1J5FI@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Peptidoglycan polymerase that is essential for cell division ftsW GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0008360,GO:0009987,GO:0015647,GO:0015648,GO:0015835,GO:0015836,GO:0016020,GO:0016021,GO:0022603,GO:0022604,GO:0022857,GO:0022884,GO:0031224,GO:0031226,GO:0032153,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0051179,GO:0051234,GO:0051301,GO:0055085,GO:0065007,GO:0065008,GO:0071702,GO:0071705,GO:0071944,GO:1901264,GO:1901505 - ko:K03588 ko04112,map04112 - - - ko00000,ko00001,ko02000,ko03036 2.A.103.1 - - FTSW_RODA_SPOVE k59_1440572_1 1334046.AYTB01000012_gene151 6.49e-27 105.0 COG1545@1|root,COG1545@2|Bacteria,1V56G@1239|Firmicutes,4HHYB@91061|Bacilli,26FGY@186818|Planococcaceae 91061|Bacilli S Rubredoxin-like zinc ribbon domain (DUF35_N) - - - ko:K07068 - - - - ko00000 - - - DUF35_N,OB_aCoA_assoc k59_1558503_1 1086011.HJ01_02020 4.06e-15 69.7 COG2841@1|root,COG2841@2|Bacteria,4PCQ8@976|Bacteroidetes,1ID92@117743|Flavobacteriia,2NXRK@237|Flavobacterium 976|Bacteroidetes S Protein of unknown function (DUF465) - - - ko:K09794 - - - - ko00000 - - - DUF465 k59_1558503_2 1123279.ATUS01000007_gene3080 1.65e-122 369.0 COG0480@1|root,COG0480@2|Bacteria,1MUCV@1224|Proteobacteria,1RNSZ@1236|Gammaproteobacteria,1J4UF@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome fusA GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2 k59_987998_1 1232410.KI421415_gene3060 1.46e-97 296.0 COG0826@1|root,COG0826@2|Bacteria,1QMCE@1224|Proteobacteria,42PSK@68525|delta/epsilon subdivisions,2WKMU@28221|Deltaproteobacteria,43UGW@69541|Desulfuromonadales 28221|Deltaproteobacteria O Peptidase family U32 - - - - - - - - - - - - Peptidase_U32 k59_1102147_1 1122137.AQXF01000001_gene3018 1.23e-175 499.0 COG2070@1|root,COG2070@2|Bacteria,1N52W@1224|Proteobacteria,2TV8B@28211|Alphaproteobacteria 28211|Alphaproteobacteria S 2-Nitropropane dioxygenase - - 1.13.12.16 ko:K00459 ko00910,map00910 - R00025 RC02541,RC02759 ko00000,ko00001,ko01000 - - - NMO k59_32251_1 1267005.KB911257_gene1150 1.73e-36 137.0 COG2271@1|root,COG2271@2|Bacteria,1QXP5@1224|Proteobacteria,2TXP1@28211|Alphaproteobacteria 28211|Alphaproteobacteria G Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 k59_424510_1 378753.KRH_18590 1.12e-16 82.4 COG0300@1|root,COG0300@2|Bacteria,2GKJE@201174|Actinobacteria,1W8W2@1268|Micrococcaceae 201174|Actinobacteria S Belongs to the short-chain dehydrogenases reductases (SDR) family - - - ko:K07124 - - - - ko00000 - - - adh_short k59_1667867_1 316407.85674556 1.39e-29 107.0 COG0781@1|root,COG0781@2|Bacteria,1RHFZ@1224|Proteobacteria,1S6AJ@1236|Gammaproteobacteria,3XPIS@561|Escherichia 1236|Gammaproteobacteria K Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons nusB GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006353,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576 - ko:K03625 - - - - ko00000,ko03009,ko03021 - - - NusB k59_1667867_2 316407.85674557 1.15e-75 233.0 COG0611@1|root,COG0611@2|Bacteria,1MU9X@1224|Proteobacteria,1RNHU@1236|Gammaproteobacteria,3XMHS@561|Escherichia 1236|Gammaproteobacteria F Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 thiL GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009030,GO:0009058,GO:0009108,GO:0009110,GO:0009228,GO:0009229,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0017076,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0035639,GO:0036094,GO:0042357,GO:0042364,GO:0042723,GO:0042724,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046483,GO:0046872,GO:0051186,GO:0051188,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.7.4.16 ko:K00946 ko00730,ko01100,map00730,map01100 M00127 R00617 RC00002 ko00000,ko00001,ko00002,ko01000 - - iSFV_1184.SFV_0382 AIRS,AIRS_C k59_143551_1 1122137.AQXF01000001_gene3361 0.0 1646.0 COG2902@1|root,COG2902@2|Bacteria,1MXNV@1224|Proteobacteria,2TS89@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Dehydrogenase gdhB GO:0003674,GO:0003824,GO:0004352,GO:0004353,GO:0008150,GO:0008152,GO:0016491,GO:0016638,GO:0016639,GO:0055114 1.4.1.2 ko:K15371 ko00220,ko00250,ko00430,ko00910,ko01100,map00220,map00250,map00430,map00910,map01100 - R00243 RC00006,RC02799 ko00000,ko00001,ko01000 - - - Bac_GDH k59_649897_1 273371.XP_003869437.1 3.12e-36 139.0 COG0209@1|root,KOG1112@2759|Eukaryota,38B81@33154|Opisthokonta,3NWE4@4751|Fungi,3QKVZ@4890|Ascomycota,3RS41@4891|Saccharomycetes,47ASA@766764|Debaryomycetaceae 4751|Fungi F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides - - 1.17.4.1 ko:K10807 ko00230,ko00240,ko00480,ko00983,ko01100,map00230,map00240,map00480,map00983,map01100 M00053 R02017,R02019,R02024,R08363,R08364,R11893 RC00613,RC01003 ko00000,ko00001,ko00002,ko01000,ko03400 - - - ATP-cone,Ribonuc_red_lgC,Ribonuc_red_lgN k59_315127_1 1122622.ATWJ01000009_gene3390 5.26e-10 60.5 COG0053@1|root,COG0053@2|Bacteria,2GQJJ@201174|Actinobacteria,4FFVU@85021|Intrasporangiaceae 201174|Actinobacteria P integral membrane protein - - - - - - - - - - - - Cation_efflux k59_315127_2 1210884.HG799462_gene8307 1.54e-143 416.0 COG0798@1|root,COG0798@2|Bacteria,2IY8H@203682|Planctomycetes 203682|Planctomycetes P COG0798 Arsenite efflux pump ACR3 and related - - - ko:K03325 - - - - ko00000,ko02000 2.A.59 - - SBF k59_596552_1 519989.ECTPHS_05325 2.17e-147 424.0 COG0180@1|root,COG0180@2|Bacteria,1MV4T@1224|Proteobacteria,1RNDC@1236|Gammaproteobacteria,1WW43@135613|Chromatiales 135613|Chromatiales J TIGRFAM Tryptophanyl-tRNA synthetase trpS - 6.1.1.2 ko:K01867 ko00970,map00970 M00359,M00360 R03664 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_1b k59_199466_1 572477.Alvin_1296 8.71e-31 118.0 COG0628@1|root,COG0628@2|Bacteria,1MVX7@1224|Proteobacteria,1RNN1@1236|Gammaproteobacteria,1WXTE@135613|Chromatiales 135613|Chromatiales S Pfam:UPF0118 - - - - - - - - - - - - AI-2E_transport k59_199466_2 999550.KI421507_gene3661 9.73e-06 48.9 COG0664@1|root,COG1132@1|root,COG4988@1|root,COG0664@2|Bacteria,COG1132@2|Bacteria,COG4988@2|Bacteria,1MWTY@1224|Proteobacteria,2TRSY@28211|Alphaproteobacteria 28211|Alphaproteobacteria V ABC-type multidrug transport system ATPase and permease - - - ko:K02021 - - - - ko00000,ko02000 3.A.1.106,3.A.1.110,3.A.1.112,3.A.1.113,3.A.1.117,3.A.1.21 - - ABC_membrane,ABC_tran,cNMP_binding k59_315135_1 95619.PM1_0206255 6.72e-95 290.0 COG0064@1|root,COG0064@2|Bacteria,1MUKG@1224|Proteobacteria,1RP7U@1236|Gammaproteobacteria 1236|Gammaproteobacteria J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) gatB GO:0003674,GO:0003824,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564 6.3.5.6,6.3.5.7 ko:K02434 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - GatB_N,GatB_Yqey k59_480088_1 436308.Nmar_0471 3.25e-94 296.0 COG1948@1|root,arCOG02284@2157|Archaea,41T0R@651137|Thaumarchaeota 651137|Thaumarchaeota L Beta propeller domain - - - - - - - - - - - - Beta_propel k59_371860_1 1415778.JQMM01000001_gene1015 6.76e-117 348.0 COG0195@1|root,COG0195@2|Bacteria,1MWT7@1224|Proteobacteria,1RNQS@1236|Gammaproteobacteria,1J4C0@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria K Participates in both transcription termination and antitermination nusA GO:0001000,GO:0001121,GO:0001125,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006353,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0019899,GO:0019904,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043175,GO:0043244,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0070063,GO:0071704,GO:0080090,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576,GO:1903506,GO:2000112,GO:2001141 - ko:K02600 - - - - ko00000,ko03009,ko03021 - - - HHH_5,KH_5,NusA_N,S1 k59_1160206_1 3988.XP_002528747.1 9.17e-19 83.2 COG0454@1|root,KOG3396@2759|Eukaryota,37U5I@33090|Viridiplantae,3GI5M@35493|Streptophyta,4JP31@91835|fabids 35493|Streptophyta M Glucosamine 6-phosphate - GO:0003674,GO:0003824,GO:0004343,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005783,GO:0006040,GO:0006044,GO:0006047,GO:0006048,GO:0006139,GO:0006725,GO:0006793,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0009058,GO:0009225,GO:0009226,GO:0009987,GO:0012505,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0018130,GO:0019438,GO:0034641,GO:0034654,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046349,GO:0046483,GO:0055086,GO:0071704,GO:1901071,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901576 2.3.1.4 ko:K00621 ko00520,map00520 - R02058 RC00004,RC00166 ko00000,ko00001,ko01000 - - - Acetyltransf_1 k59_1160206_2 436308.Nmar_0541 8.99e-25 99.0 COG1208@1|root,arCOG00666@2157|Archaea 2157|Archaea JM COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits (eIF-2Bgamma eIF-2Bepsilon) - - 2.7.7.13 ko:K00966 ko00051,ko00520,ko01100,ko01110,map00051,map00520,map01100,map01110 M00114,M00361,M00362 R00885 RC00002 ko00000,ko00001,ko00002,ko01000 - - - Hexapep,NTP_transferase k59_315141_1 398767.Glov_1245 9.38e-83 254.0 COG0217@1|root,COG0217@2|Bacteria,1MW3X@1224|Proteobacteria,42N7Q@68525|delta/epsilon subdivisions,2WJ1I@28221|Deltaproteobacteria 28221|Deltaproteobacteria K transcriptional regulatory protein yebC GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - - - - - - - - - - Transcrip_reg k59_1102166_1 114615.BRADO6334 5.86e-27 109.0 COG0760@1|root,COG0760@2|Bacteria,1R4ZR@1224|Proteobacteria,2U874@28211|Alphaproteobacteria,3JRK1@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria O PPIC-type PPIASE domain - - 5.2.1.8 ko:K03769 - - - - ko00000,ko01000,ko03110 - - - Rotamase_2 k59_257148_1 1122599.AUGR01000006_gene3782 1.5e-24 102.0 28I6N@1|root,2Z89J@2|Bacteria,1MUVT@1224|Proteobacteria,1RQUY@1236|Gammaproteobacteria,1XHY9@135619|Oceanospirillales 135619|Oceanospirillales - - - - - - - - - - - - - - - k59_1160213_1 316407.1805566 3.29e-130 390.0 COG2200@1|root,COG2200@2|Bacteria,1N299@1224|Proteobacteria,1RN30@1236|Gammaproteobacteria,3XMW8@561|Escherichia 1236|Gammaproteobacteria T Truncated proteins consisting of the GGDEF EAL domains (residues 319-747) or of the EAL domain alone (481-747) have c-di- GMP phosphodiesterase activity. They do not have diguanylate cyclase activity. Cyclic-di-GMP is a second messenger which controls cell surface-associated traits in bacteria yfgF GO:0000302,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006950,GO:0006979,GO:0008081,GO:0008150,GO:0009628,GO:0009636,GO:0009987,GO:0010035,GO:0016020,GO:0016021,GO:0016787,GO:0016788,GO:0031224,GO:0033554,GO:0034059,GO:0034599,GO:0034614,GO:0035690,GO:0036293,GO:0036294,GO:0042221,GO:0042493,GO:0042542,GO:0042578,GO:0043900,GO:0044425,GO:0044464,GO:0046677,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0070301,GO:0070482,GO:0070887,GO:0071111,GO:0071236,GO:0071453,GO:0071454,GO:0071944,GO:0097237,GO:1900190,GO:1901700,GO:1901701 - - - - - - - - - - EAL,MASE1 k59_1725801_1 1207055.C100_16840 2.42e-21 94.0 COG3119@1|root,COG3119@2|Bacteria,1MUJH@1224|Proteobacteria,2TSB8@28211|Alphaproteobacteria,2K9FA@204457|Sphingomonadales 204457|Sphingomonadales P Sulfatase - - - - - - - - - - - - Sulfatase k59_1725801_2 83219.PM02_18660 8.65e-13 68.9 COG1609@1|root,COG1609@2|Bacteria,1MVUR@1224|Proteobacteria,2TTHH@28211|Alphaproteobacteria 28211|Alphaproteobacteria K LacI family - - - ko:K02529 - - - - ko00000,ko03000 - - - LacI,Peripla_BP_3 k59_880199_1 1172179.AUKV01000011_gene3809 1.13e-20 92.8 COG0614@1|root,COG0614@2|Bacteria,2GYJE@201174|Actinobacteria 201174|Actinobacteria P ABC-type Fe3 -hydroxamate transport system, periplasmic component - - - - - - - - - - - - Peripla_BP_2 k59_880199_2 644282.Deba_1409 4.56e-70 231.0 COG0327@1|root,COG0327@2|Bacteria,1R34P@1224|Proteobacteria,42MAY@68525|delta/epsilon subdivisions,2X5HJ@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Belongs to the GTP cyclohydrolase I type 2 NIF3 family - - - - - - - - - - - - NIF3 k59_1049424_1 1232410.KI421425_gene1552 3.06e-78 263.0 COG2885@1|root,COG2885@2|Bacteria,1QW22@1224|Proteobacteria,42TDV@68525|delta/epsilon subdivisions,2WP7K@28221|Deltaproteobacteria,43UHJ@69541|Desulfuromonadales 28221|Deltaproteobacteria M OmpA family - - - - - - - - - - - - OmpA k59_1501588_2 102125.Xen7305DRAFT_00010720 7.62e-37 139.0 COG0457@1|root,COG0859@1|root,COG1216@1|root,COG4122@1|root,COG0457@2|Bacteria,COG0859@2|Bacteria,COG1216@2|Bacteria,COG4122@2|Bacteria,1GIUH@1117|Cyanobacteria,3VN7M@52604|Pleurocapsales 1117|Cyanobacteria M Tetratricopeptide repeat - - - - - - - - - - - - TPR_1,TPR_8 k59_1049438_1 1178825.ALIH01000008_gene718 3.17e-118 348.0 COG0327@1|root,COG0327@2|Bacteria,4NF51@976|Bacteroidetes,1HXRQ@117743|Flavobacteriia 976|Bacteroidetes S Belongs to the GTP cyclohydrolase I type 2 NIF3 family yqfO - - - - - - - - - - - NIF3 k59_1102189_1 234826.AM1312 6.65e-34 135.0 COG3505@1|root,COG3505@2|Bacteria,1MV1G@1224|Proteobacteria,2TR6N@28211|Alphaproteobacteria,47EW8@766|Rickettsiales 766|Rickettsiales U Type IV secretion system protein VirD4 virD4 - - ko:K03205 ko03070,map03070 M00333 - - ko00000,ko00001,ko00002,ko02044 3.A.7 - - T4SS-DNA_transf k59_371904_1 702113.PP1Y_AT5689 5.74e-66 212.0 COG3287@1|root,COG3287@2|Bacteria,1MVUZ@1224|Proteobacteria,2TRRI@28211|Alphaproteobacteria,2K356@204457|Sphingomonadales 204457|Sphingomonadales S FIST_C - - - - - - - - - - - - FIST,FIST_C k59_535398_1 1122137.AQXF01000006_gene898 1.42e-91 288.0 COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,2TS8E@28211|Alphaproteobacteria 28211|Alphaproteobacteria I enoyl-CoA hydratase - - 1.1.1.35 ko:K07516 ko00071,ko00362,ko00650,ko01100,ko01120,ko01200,ko01212,map00071,map00362,map00650,map01100,map01120,map01200,map01212 M00087 R01975,R04737,R04739,R04741,R04743,R04745,R04748,R05305 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000 - - - 3HCDH,3HCDH_N,ECH_1 k59_431762_1 1189612.A33Q_4456 0.000203 47.0 COG2010@1|root,COG2010@2|Bacteria,4NKQI@976|Bacteroidetes,47PEX@768503|Cytophagia 976|Bacteroidetes C PFAM Cytochrome C actE - - - - - - - - - - - Cytochrome_CBB3 k59_324029_1 1121033.AUCF01000026_gene2980 4.61e-77 240.0 COG2828@1|root,COG2828@2|Bacteria,1MXVV@1224|Proteobacteria,2TQMC@28211|Alphaproteobacteria,2JQ10@204441|Rhodospirillales 204441|Rhodospirillales S PrpF protein - - - - - - - - - - - - PrpF k59_718953_1 1122137.AQXF01000003_gene1897 8.03e-101 303.0 COG1680@1|root,COG1680@2|Bacteria,1NHIY@1224|Proteobacteria,2U0A3@28211|Alphaproteobacteria 28211|Alphaproteobacteria V Beta-lactamase class C and other penicillin binding proteins - - - - - - - - - - - - Beta-lactamase k59_487520_1 458817.Shal_4291 1.15e-12 67.0 COG1136@1|root,COG1136@2|Bacteria,1MU45@1224|Proteobacteria,1SYJN@1236|Gammaproteobacteria,2QB96@267890|Shewanellaceae 1236|Gammaproteobacteria V ATPases associated with a variety of cellular activities - - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_487520_2 1267535.KB906767_gene3303 4.78e-26 114.0 COG0577@1|root,COG0577@2|Bacteria,3Y6XU@57723|Acidobacteria 57723|Acidobacteria V MacB-like periplasmic core domain - - - - - - - - - - - - FtsX,MacB_PCD k59_889072_1 1122137.AQXF01000001_gene2924 3.78e-135 409.0 COG3127@1|root,COG3127@2|Bacteria,1MU9R@1224|Proteobacteria,2TS8V@28211|Alphaproteobacteria 28211|Alphaproteobacteria Q ABC-type transport system involved in lysophospholipase L1 biosynthesis permease component MA20_43810 - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_1057178_1 1525715.IX54_05180 3.74e-96 290.0 COG3328@1|root,COG3328@2|Bacteria,1MU4P@1224|Proteobacteria,2TUQT@28211|Alphaproteobacteria,2PV9X@265|Paracoccus 28211|Alphaproteobacteria L Transposase, Mutator family - - - - - - - - - - - - Transposase_mut k59_380518_1 768671.ThimaDRAFT_3757 2.16e-56 191.0 COG0421@1|root,COG0421@2|Bacteria,1QZ2Z@1224|Proteobacteria 1224|Proteobacteria E Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine - - - - - - - - - - - - - k59_1278485_1 187272.Mlg_1798 3.25e-84 263.0 COG0517@1|root,COG0517@2|Bacteria,1MXI6@1224|Proteobacteria,1RYPY@1236|Gammaproteobacteria 1236|Gammaproteobacteria S PFAM Transposase, IS801 IS1294 - - - - - - - - - - - - Y2_Tnp,Zn_Tnp_IS91 k59_769859_1 1089550.ATTH01000001_gene1819 3.78e-82 257.0 COG0015@1|root,COG0015@2|Bacteria,4NFY8@976|Bacteroidetes,1FJ4B@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes F Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily purB - 4.3.2.2 ko:K01756 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048,M00049 R01083,R04559 RC00379,RC00444,RC00445 ko00000,ko00001,ko00002,ko01000 - - - ADSL_C,ASL_C,Lyase_1 k59_657671_1 1500301.JQMF01000018_gene3123 7.52e-40 146.0 COG0477@1|root,COG2814@2|Bacteria,1MVVW@1224|Proteobacteria,2TVQU@28211|Alphaproteobacteria,4B81V@82115|Rhizobiaceae 28211|Alphaproteobacteria EGP Major facilitator superfamily MA20_07145 - - - - - - - - - - - MFS_1 k59_657671_2 1122137.AQXF01000001_gene2841 1.42e-69 213.0 COG1403@1|root,COG1403@2|Bacteria,1MWEQ@1224|Proteobacteria,2TR3M@28211|Alphaproteobacteria 28211|Alphaproteobacteria L HNH endonuclease MA20_20605 - - - - - - - - - - - HNH,HNH_5 k59_96646_1 1122137.AQXF01000003_gene2261 6.59e-217 634.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2TQT0@28211|Alphaproteobacteria 28211|Alphaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_1109774_1 287986.DV20_12570 2.13e-27 111.0 COG0491@1|root,COG0491@2|Bacteria,2GMSA@201174|Actinobacteria,4E8AV@85010|Pseudonocardiales 201174|Actinobacteria S Metallo-beta-lactamase superfamily - - - - - - - - - - - - Lactamase_B k59_1620674_1 1250278.JQNQ01000001_gene1982 2.24e-84 257.0 COG2207@1|root,COG2207@2|Bacteria,4NEEQ@976|Bacteroidetes,1HXZM@117743|Flavobacteriia 976|Bacteroidetes K AraC family - - - - - - - - - - - - HTH_18 k59_324098_1 1280948.HY36_09940 4.46e-48 158.0 COG3324@1|root,COG3324@2|Bacteria,1RBHJ@1224|Proteobacteria,2U6F9@28211|Alphaproteobacteria,43ZUZ@69657|Hyphomonadaceae 28211|Alphaproteobacteria S glyoxalase bleomycin resistance protein dioxygenase - - - - - - - - - - - - - k59_718988_1 997346.HMPREF9374_1022 1.22e-50 174.0 COG0812@1|root,COG0812@2|Bacteria,1TP3W@1239|Firmicutes,4HAD8@91061|Bacilli,27AU8@186824|Thermoactinomycetaceae 91061|Bacilli M UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain murB - 1.3.1.98 ko:K00075 ko00520,ko00550,ko01100,map00520,map00550,map01100 - R03191,R03192 RC02639 ko00000,ko00001,ko01000,ko01011 - - iYO844.BSU15230 FAD_binding_4,MurB_C k59_718988_3 765911.Thivi_2314 1.49e-37 137.0 COG0849@1|root,COG0849@2|Bacteria,1MUSR@1224|Proteobacteria,1RMXY@1236|Gammaproteobacteria,1WVUV@135613|Chromatiales 135613|Chromatiales D Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring ftsA - - ko:K03590 ko04112,map04112 - - - ko00000,ko00001,ko03036,ko04812 - - - FtsA,SHS2_FTSA k59_1225146_1 1030157.AFMP01000033_gene2783 2.11e-28 123.0 2CH5T@1|root,31C81@2|Bacteria,1Q887@1224|Proteobacteria,2V77E@28211|Alphaproteobacteria,2K97Z@204457|Sphingomonadales 204457|Sphingomonadales - - - - - - - - - - - - - - - k59_487574_1 648757.Rvan_0605 1.45e-80 243.0 COG2210@1|root,COG2210@2|Bacteria,1RDUG@1224|Proteobacteria,2U6FZ@28211|Alphaproteobacteria 28211|Alphaproteobacteria S DsrE/DsrF/DrsH-like family - - - - - - - - - - - - DrsE_2 k59_40984_1 1101189.AQUO01000001_gene2099 5.99e-19 85.5 COG0559@1|root,COG0559@2|Bacteria,1N54M@1224|Proteobacteria,2TTF5@28211|Alphaproteobacteria,2PVIR@265|Paracoccus 28211|Alphaproteobacteria E Branched-chain amino acid transport system / permease component livH3 - - ko:K01997 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - BPD_transp_2 k59_40984_2 991905.SL003B_0832 2.82e-52 171.0 COG0411@1|root,COG0411@2|Bacteria,1MUTY@1224|Proteobacteria,2TQK1@28211|Alphaproteobacteria,4BRCY@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria E Branched-chain amino acid ATP-binding cassette transporter cysA - - ko:K01995,ko:K01998 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - ABC_tran,BCA_ABC_TP_C k59_324106_1 1121396.KB892950_gene2992 8.8e-17 79.3 COG2199@1|root,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria,43BSG@68525|delta/epsilon subdivisions,2WMXZ@28221|Deltaproteobacteria,2MJS0@213118|Desulfobacterales 28221|Deltaproteobacteria T diguanylate cyclase - - - - - - - - - - - - GGDEF,Response_reg k59_1057217_1 118173.KB235914_gene2358 4.3e-22 90.9 COG3657@1|root,COG3657@2|Bacteria,1G6YT@1117|Cyanobacteria,1HCJV@1150|Oscillatoriales 1117|Cyanobacteria S Phage derived protein Gp49-like (DUF891) - - - - - - - - - - - - Gp49 k59_1398281_1 1121374.KB891585_gene2202 2.28e-34 125.0 COG1225@1|root,COG1225@2|Bacteria,1MWFZ@1224|Proteobacteria,1RZ28@1236|Gammaproteobacteria 1236|Gammaproteobacteria O COG1225 Peroxiredoxin - - - - - - - - - - - - AhpC-TSA k59_1398281_2 483219.LILAB_06115 3.81e-129 382.0 COG0624@1|root,COG0624@2|Bacteria,1MW20@1224|Proteobacteria,437V8@68525|delta/epsilon subdivisions,2X34Q@28221|Deltaproteobacteria,2YU9A@29|Myxococcales 28221|Deltaproteobacteria E Peptidase dimerisation domain dapE1 - - - - - - - - - - - M20_dimer,Peptidase_M20 k59_719975_1 1415778.JQMM01000001_gene713 1.24e-279 789.0 COG3605@1|root,COG3605@2|Bacteria,1QTTV@1224|Proteobacteria,1T1H2@1236|Gammaproteobacteria,1J4VF@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T Belongs to the PEP-utilizing enzyme family ptsP GO:0003674,GO:0003824,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008965,GO:0009987,GO:0010033,GO:0010243,GO:0016310,GO:0016740,GO:0016772,GO:0016775,GO:0019538,GO:0036211,GO:0042221,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0050896,GO:0071704,GO:1901564,GO:1901698 2.7.3.9 ko:K08484 ko02060,map02060 - - - ko00000,ko00001,ko01000,ko02000 - - - GAF,GAF_2,PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C k59_543631_1 702113.PP1Y_Mpl8095 3.52e-43 161.0 COG1472@1|root,COG1472@2|Bacteria,1MVIV@1224|Proteobacteria,2TS28@28211|Alphaproteobacteria,2JZVY@204457|Sphingomonadales 204457|Sphingomonadales G Belongs to the glycosyl hydrolase 3 family - - 3.2.1.21 ko:K05349 ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110 - R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040 RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248 ko00000,ko00001,ko01000 - GH3 - Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C k59_266949_1 526222.Desal_2437 7.52e-97 291.0 COG0115@1|root,COG0115@2|Bacteria,1MVB0@1224|Proteobacteria,42MKX@68525|delta/epsilon subdivisions,2WKXU@28221|Deltaproteobacteria,2M80I@213115|Desulfovibrionales 28221|Deltaproteobacteria E Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family ilvE - 2.6.1.42 ko:K00826 ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00036,M00119,M00570 R01090,R01214,R02199,R10991 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_4 k59_97686_1 511145.b2901 1.01e-63 206.0 COG2723@1|root,COG2723@2|Bacteria,1MWG6@1224|Proteobacteria,1RMM2@1236|Gammaproteobacteria,3XM82@561|Escherichia 1236|Gammaproteobacteria G Belongs to the glycosyl hydrolase 1 family bglA GO:0003674,GO:0003824,GO:0004553,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005984,GO:0008150,GO:0008152,GO:0008422,GO:0008706,GO:0009056,GO:0009311,GO:0009313,GO:0009987,GO:0015926,GO:0016052,GO:0016787,GO:0016798,GO:0044237,GO:0044238,GO:0044248,GO:0044262,GO:0044275,GO:0044424,GO:0044444,GO:0044464,GO:0046352,GO:0071704,GO:1901135,GO:1901575,GO:1901657,GO:2000891,GO:2000892 3.2.1.21,3.2.1.86 ko:K01223,ko:K05350 ko00010,ko00460,ko00500,ko00940,ko01100,ko01110,map00010,map00460,map00500,map00940,map01100,map01110 - R00026,R00839,R02558,R02887,R02985,R03527,R04949,R04998,R05133,R05134,R10035,R10039,R10040 RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248 ko00000,ko00001,ko01000 - GT1 iEC55989_1330.EC55989_3188,iSSON_1240.SSON_3054 Glyco_hydro_1 k59_97686_2 316407.85675712 5.98e-42 138.0 COG3097@1|root,COG3097@2|Bacteria,1N1TE@1224|Proteobacteria,1SB7Z@1236|Gammaproteobacteria,3XPR9@561|Escherichia 1236|Gammaproteobacteria S Belongs to the UPF0267 family yqfB GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - ko:K09900 - - - - ko00000 - - - ASCH k59_829685_1 269796.Rru_A3279 2.6e-10 60.1 COG2960@1|root,COG2960@2|Bacteria,1N725@1224|Proteobacteria,2UFEP@28211|Alphaproteobacteria,2JU3E@204441|Rhodospirillales 204441|Rhodospirillales S Membrane fusogenic activity - - - ko:K09806 - - - - ko00000 - - - BMFP k59_829685_2 1122137.AQXF01000003_gene2024 3.96e-65 206.0 COG0682@1|root,COG0682@2|Bacteria,1MVE3@1224|Proteobacteria,2TTNS@28211|Alphaproteobacteria 28211|Alphaproteobacteria M Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins lgt - - ko:K13292 - - - - ko00000,ko01000 - - - LGT k59_941175_1 1229909.NSED_05295 1.45e-79 246.0 COG2064@1|root,arCOG01808@2157|Archaea 2157|Archaea NU Type II secretion system - - - ko:K07333 - - - - ko00000,ko02035,ko02044 - - - T2SSF k59_996643_1 1123517.JOMR01000001_gene953 5.6e-61 203.0 COG0286@1|root,COG0286@2|Bacteria,1MW3A@1224|Proteobacteria,1RMRA@1236|Gammaproteobacteria,4602M@72273|Thiotrichales 72273|Thiotrichales V TIGRFAM type I restriction system adenine methylase (hsdM) - - 2.1.1.72 ko:K03427 - - - - ko00000,ko01000,ko02048 - - - HsdM_N,N6_Mtase k59_97701_1 196162.Noca_4479 4.65e-56 188.0 COG1609@1|root,COG1609@2|Bacteria,2GNVD@201174|Actinobacteria,4DQZJ@85009|Propionibacteriales 201174|Actinobacteria K helix_turn _helix lactose operon repressor - - - ko:K02529 - - - - ko00000,ko03000 - - - LacI,Peripla_BP_3 k59_941181_1 1122137.AQXF01000004_gene1794 5.52e-94 286.0 COG0766@1|root,COG0766@2|Bacteria,1MUH7@1224|Proteobacteria,2TRPH@28211|Alphaproteobacteria 28211|Alphaproteobacteria M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine murA - 2.5.1.7 ko:K00790 ko00520,ko00550,ko01100,map00520,map00550,map01100 - R00660 RC00350 ko00000,ko00001,ko01000,ko01011 - - - EPSP_synthase k59_941181_2 743722.Sph21_2720 1.28e-09 57.0 COG3576@1|root,COG3576@2|Bacteria,4NRA3@976|Bacteroidetes,1IYNT@117747|Sphingobacteriia 976|Bacteroidetes S Pfam:Pyridox_oxidase - - - ko:K07006 - - - - ko00000 - - - Putative_PNPOx k59_658914_1 46429.BV95_01203 4.39e-33 131.0 COG4774@1|root,COG4774@2|Bacteria,1NT9E@1224|Proteobacteria,2UQ4P@28211|Alphaproteobacteria,2KCYG@204457|Sphingomonadales 204457|Sphingomonadales P TonB dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_325067_1 1112217.PPL19_06576 5.18e-99 295.0 COG0059@1|root,COG0059@2|Bacteria,1MV7M@1224|Proteobacteria,1RNA8@1236|Gammaproteobacteria 1236|Gammaproteobacteria EH Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate ilvC GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004455,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006549,GO:0006573,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009097,GO:0009099,GO:0009987,GO:0016043,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0022607,GO:0036094,GO:0042802,GO:0043167,GO:0043169,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046872,GO:0048037,GO:0050661,GO:0050662,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:0097159,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.86 ko:K00053 ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R03051,R04439,R04440,R05068,R05069,R05071 RC00726,RC00836,RC00837,RC01726 ko00000,ko00001,ko00002,ko01000 - - iEC042_1314.EC042_4152,iECABU_c1320.ECABU_c42560,iECED1_1282.ECED1_4460,iECO103_1326.ECO103_4390,iECO111_1330.ECO111_4600,iECO26_1355.ECO26_4812,iECP_1309.ECP_3967,iECSE_1348.ECSE_4057,iECUMN_1333.ECUMN_4300,iEcE24377_1341.EcE24377A_4285,iEcSMS35_1347.EcSMS35_4140,iJN746.PP_4678,iLF82_1304.LF82_1103 IlvC,IlvN k59_1676131_1 344747.PM8797T_11074 4.37e-69 243.0 COG0004@1|root,COG5002@1|root,COG0004@2|Bacteria,COG5002@2|Bacteria,2IYBN@203682|Planctomycetes 203682|Planctomycetes P Ammonium Transporter Family - - - ko:K03320 - - - - ko00000,ko02000 1.A.11 - - Ammonium_transp,HATPase_c,HisKA k59_1734201_1 314287.GB2207_08661 1.69e-76 238.0 COG0204@1|root,COG0204@2|Bacteria,1MY51@1224|Proteobacteria,1RQYC@1236|Gammaproteobacteria,1J5YI@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria I Acyltransferase hdtS - 2.3.1.51 ko:K00655 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R02241,R09381 RC00004,RC00037,RC00039 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Acyltransferase k59_996686_1 1229909.NSED_01405 6.3e-56 185.0 COG0750@1|root,arCOG00609@2157|Archaea,41S8V@651137|Thaumarchaeota 651137|Thaumarchaeota M Peptidase family M50 - - - - - - - - - - - - Peptidase_M50 k59_1734223_1 627192.SLG_20440 4.89e-29 119.0 COG1629@1|root,COG4771@2|Bacteria,1MWKN@1224|Proteobacteria,2TTFY@28211|Alphaproteobacteria,2K075@204457|Sphingomonadales 204457|Sphingomonadales P receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_1786220_2 391603.FBALC1_01432 1.24e-57 197.0 COG1629@1|root,COG4771@2|Bacteria,4NEHN@976|Bacteroidetes,1IJ7E@117743|Flavobacteriia 976|Bacteroidetes P TonB-dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - CarbopepD_reg_2,Plug,TonB_dep_Rec k59_606954_1 479432.Sros_8254 1.57e-14 76.6 COG1062@1|root,COG1062@2|Bacteria,2GM8C@201174|Actinobacteria,4EG7Z@85012|Streptosporangiales 201174|Actinobacteria C Alcohol dehydrogenase GroES-like domain - - 1.1.1.1,1.1.1.284 ko:K00121 ko00010,ko00071,ko00350,ko00625,ko00626,ko00680,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,ko05204,map00010,map00071,map00350,map00625,map00626,map00680,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01200,map01220,map05204 - R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R06983,R07105,R08281,R08306,R08310 RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01715,RC01734,RC02273 ko00000,ko00001,ko01000 - - - ADH_N,ADH_zinc_N k59_770946_2 396588.Tgr7_1687 1.03e-05 50.4 2BHUM@1|root,32BYB@2|Bacteria,1NHRH@1224|Proteobacteria,1SVAX@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Putative bacterial sensory transduction regulator - - - - - - - - - - - - YbjN k59_543702_1 1121878.AUGL01000021_gene2815 1.88e-71 234.0 28HMZ@1|root,2Z7WD@2|Bacteria,1MU3Q@1224|Proteobacteria,1RRUM@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Protein of unknown function (DUF3604) - - - - - - - - - - - - DUF3604 k59_606998_1 436308.Nmar_1701 4.65e-86 258.0 COG1468@1|root,arCOG00790@2157|Archaea,41T4T@651137|Thaumarchaeota 651137|Thaumarchaeota V CRISPR-associated protein Cas4 - - 3.1.12.1 ko:K07464 - - - - ko00000,ko01000,ko02048 - - - - k59_267052_1 278957.ABEA03000071_gene3035 3.31e-05 45.4 COG0048@1|root,COG0048@2|Bacteria,46SQR@74201|Verrucomicrobia,3K7YQ@414999|Opitutae 414999|Opitutae J Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit rpsL - - ko:K02950 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosom_S12_S23 k59_267052_2 926569.ANT_09980 2.83e-55 192.0 COG0085@1|root,COG0085@2|Bacteria,2G5VH@200795|Chloroflexi 200795|Chloroflexi K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoB GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234 2.7.7.6 ko:K03043 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7 k59_1568860_1 1320556.AVBP01000012_gene3522 1.97e-88 269.0 COG0190@1|root,COG0190@2|Bacteria,1MWU4@1224|Proteobacteria,2TRZZ@28211|Alphaproteobacteria,43I3N@69277|Phyllobacteriaceae 28211|Alphaproteobacteria H Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate folD GO:0003674,GO:0003824,GO:0004477,GO:0004488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006730,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016645,GO:0016646,GO:0016787,GO:0016810,GO:0016814,GO:0019238,GO:0044237,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0055114 1.5.1.5,3.5.4.9 ko:K01491 ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200 M00140,M00377 R01220,R01655 RC00202,RC00578 ko00000,ko00001,ko00002,ko01000 - - - THF_DHG_CYH,THF_DHG_CYH_C k59_209636_1 91464.S7335_721 1.27e-56 186.0 COG3385@1|root,COG3385@2|Bacteria,1G3TU@1117|Cyanobacteria,1H2E0@1129|Synechococcus 1117|Cyanobacteria L PFAM Transposase DDE domain - - - ko:K07495 - - - - ko00000 - - - DDE_5,DDE_Tnp_1 k59_543712_2 1122137.AQXF01000001_gene3264 7.81e-83 257.0 COG0265@1|root,COG0265@2|Bacteria,1P55H@1224|Proteobacteria,2U4M5@28211|Alphaproteobacteria 28211|Alphaproteobacteria O COG0265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain - - - - - - - - - - - - Trypsin_2 k59_543712_3 1122137.AQXF01000001_gene3263 4.72e-55 176.0 COG3766@1|root,COG3766@2|Bacteria,1N14W@1224|Proteobacteria,2U5NC@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Domain of Unknown Function (DUF350) - - - ko:K08989 - - - - ko00000 - - - DUF350 k59_543712_4 1122137.AQXF01000001_gene3262 3.52e-113 333.0 COG0289@1|root,COG0289@2|Bacteria,1MUCT@1224|Proteobacteria,2TSFJ@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate dapB GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008839,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0019752,GO:0019877,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576 1.17.1.8 ko:K00215 ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R04198,R04199 RC00478 ko00000,ko00001,ko00002,ko01000 - - - DapB_C,DapB_N k59_543712_5 1122137.AQXF01000001_gene3261 2.09e-174 513.0 COG1629@1|root,COG1629@2|Bacteria,COG4771@2|Bacteria,1MWKN@1224|Proteobacteria,2VFCK@28211|Alphaproteobacteria 28211|Alphaproteobacteria P TonB dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_1111127_1 1096930.L284_08265 2.44e-115 338.0 COG2070@1|root,COG2070@2|Bacteria,1MWPC@1224|Proteobacteria,2TQRT@28211|Alphaproteobacteria,2K0DQ@204457|Sphingomonadales 204457|Sphingomonadales S 2-nitropropane dioxygenase - - 1.3.1.9 ko:K02371 ko00061,ko01100,ko01212,map00061,map01100,map01212 M00083 R04429,R04724,R04955,R04958,R04961,R04966,R04969,R07765 RC00052,RC00076 ko00000,ko00001,ko00002,ko01000,ko01004 - - - NMO,ThiG k59_720051_1 1131553.JIBI01000071_gene2158 3.88e-94 291.0 COG0569@1|root,COG0569@2|Bacteria,1MW8R@1224|Proteobacteria,2VIH1@28216|Betaproteobacteria,3720Q@32003|Nitrosomonadales 28216|Betaproteobacteria C TrkA-N domain protein trkA - - ko:K03499 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - - TrkA_C,TrkA_N k59_607013_1 1219065.VPR01S_06_00480 3.91e-14 68.2 COG2050@1|root,COG2050@2|Bacteria,1RBPE@1224|Proteobacteria,1SCN1@1236|Gammaproteobacteria,1XXCQ@135623|Vibrionales 135623|Vibrionales Q Thioesterase superfamily - - - - - - - - - - - - 4HBT k59_607013_2 1122201.AUAZ01000015_gene757 3.32e-47 157.0 COG3647@1|root,COG3647@2|Bacteria,1N7NB@1224|Proteobacteria,1RS4F@1236|Gammaproteobacteria,46CGS@72275|Alteromonadaceae 1236|Gammaproteobacteria S Predicted membrane protein (DUF2238) yjdF GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K08984 - - - - ko00000 - - - DUF2238 k59_996762_1 925775.XVE_4914 1.24e-20 95.9 COG1064@1|root,COG1064@2|Bacteria,1MUTT@1224|Proteobacteria,1RPQC@1236|Gammaproteobacteria,1X4TA@135614|Xanthomonadales 135614|Xanthomonadales S alcohol dehydrogenase - - 1.1.1.1 ko:K13953 ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220 - R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310 RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273 ko00000,ko00001,ko01000 - - - ADH_N,ADH_zinc_N k59_381740_1 1232410.KI421421_gene3683 2.02e-114 337.0 COG1181@1|root,COG1181@2|Bacteria,1N4F5@1224|Proteobacteria,42NYM@68525|delta/epsilon subdivisions,2WKTX@28221|Deltaproteobacteria,43U6N@69541|Desulfuromonadales 28221|Deltaproteobacteria M ATP-grasp domain - - 6.3.2.4 ko:K01921 ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502 - R01150 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Dala_Dala_lig_C k59_1449781_1 570967.JMLV01000003_gene2285 6.06e-27 115.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,2TQR7@28211|Alphaproteobacteria,2JPFH@204441|Rhodospirillales 204441|Rhodospirillales NT methyl-accepting chemotaxis protein - - - - - - - - - - - - HAMP,MCPsignal k59_1336300_1 1385517.N800_13180 1.53e-27 116.0 COG2373@1|root,COG4932@1|root,COG2373@2|Bacteria,COG4932@2|Bacteria,1QZFW@1224|Proteobacteria 1224|Proteobacteria M domain protein - - - - - - - - - - - - DUF11,SdrD_B k59_1170225_2 1340493.JNIF01000003_gene3940 7.33e-18 84.3 COG1816@1|root,COG1816@2|Bacteria,3Y2R0@57723|Acidobacteria 57723|Acidobacteria F PFAM Adenosine AMP deaminase - - 3.5.4.4,3.5.4.40 ko:K01488,ko:K18286 ko00130,ko00230,ko01100,ko01110,ko05340,map00130,map00230,map01100,map01110,map05340 - R01560,R02556,R10695 RC00477 ko00000,ko00001,ko01000 - - - A_deaminase k59_1449784_1 491952.Mar181_2522 5.75e-107 322.0 COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,1RMBQ@1236|Gammaproteobacteria,1XHIY@135619|Oceanospirillales 135619|Oceanospirillales C Belongs to the aldehyde dehydrogenase family - - 1.2.1.39,1.2.1.99 ko:K00146,ko:K09472 ko00330,ko00360,ko00643,ko01100,ko01120,map00330,map00360,map00643,map01100,map01120 M00136 R02536,R07417,R07418 RC00080 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_1111147_1 998674.ATTE01000001_gene2266 8.94e-83 249.0 COG0233@1|root,COG0233@2|Bacteria,1N66T@1224|Proteobacteria,1RN75@1236|Gammaproteobacteria,460EK@72273|Thiotrichales 72273|Thiotrichales J Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another frr - - ko:K02838 - - - - ko00000,ko03012 - - - RRF k59_890146_2 436308.Nmar_0597 3.16e-45 149.0 COG0073@1|root,arCOG01136@2157|Archaea,41SSY@651137|Thaumarchaeota 651137|Thaumarchaeota J Putative tRNA binding domain - - - ko:K06878 - - - - ko00000 - - - tRNA_bind k59_267082_1 247634.GPB2148_3881 7.52e-49 173.0 COG0272@1|root,COG0272@2|Bacteria,1MV3R@1224|Proteobacteria,1RPAV@1236|Gammaproteobacteria,1J4U2@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA ligA GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003909,GO:0003911,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016874,GO:0016886,GO:0033554,GO:0034641,GO:0034645,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050662,GO:0050896,GO:0051103,GO:0051287,GO:0051716,GO:0070403,GO:0071704,GO:0090304,GO:0097159,GO:0140097,GO:1901265,GO:1901360,GO:1901363,GO:1901576 6.5.1.2 ko:K01972 ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430 - R00382 RC00005 ko00000,ko00001,ko01000,ko03032,ko03400 - - iEC55989_1330.EC55989_2701,iECABU_c1320.ECABU_c27320,iECIAI1_1343.ECIAI1_2469,iECO103_1326.ECO103_2930,iECO111_1330.ECO111_3141,iECO26_1355.ECO26_3464,iECSE_1348.ECSE_2702,iECW_1372.ECW_m2640,iEKO11_1354.EKO11_1317,iEcE24377_1341.EcE24377A_2698,iEcSMS35_1347.EcSMS35_2566,iWFL_1372.ECW_m2640,iYL1228.KPN_02758,ic_1306.c2945 BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5 k59_267082_2 1121374.KB891585_gene1834 0.000167 43.9 COG4764@1|root,COG4764@2|Bacteria,1MVRK@1224|Proteobacteria,1RQ79@1236|Gammaproteobacteria 1236|Gammaproteobacteria S protein conserved in bacteria - - - - - - - - - - - - SLT k59_727816_1 338963.Pcar_1709 2.86e-40 155.0 COG3857@1|root,COG3857@2|Bacteria,1Q1TF@1224|Proteobacteria,43EZ0@68525|delta/epsilon subdivisions,2X1XI@28221|Deltaproteobacteria,43S26@69541|Desulfuromonadales 28221|Deltaproteobacteria L PD-(D/E)XK nuclease superfamily - - - - - - - - - - - - PDDEXK_1 k59_1287667_1 1217720.ALOX01000038_gene2863 2.67e-107 322.0 COG0654@1|root,COG0654@2|Bacteria,1MV8T@1224|Proteobacteria,2TRB8@28211|Alphaproteobacteria,2JQ4E@204441|Rhodospirillales 204441|Rhodospirillales CH FAD binding domain - - 1.14.13.2 ko:K00481 ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220 - R01298 RC00046 ko00000,ko00001,ko01000 - - - FAD_binding_3 k59_1793812_1 207954.MED92_00025 6.78e-87 272.0 COG0008@1|root,COG0008@2|Bacteria,1MUC8@1224|Proteobacteria,1RQ7G@1236|Gammaproteobacteria,1XHK2@135619|Oceanospirillales 135619|Oceanospirillales J Catalyzes a two-step reaction, first charging a glutamine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA glnS - 6.1.1.18 ko:K01886 ko00970,ko01100,map00970,map01100 M00359,M00360 R03652 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_1c,tRNA-synt_1c_C k59_1793813_1 316407.85674384 2.29e-61 200.0 COG0741@1|root,COG1388@1|root,COG0741@2|Bacteria,COG1388@2|Bacteria,1MWKE@1224|Proteobacteria,1RMFZ@1236|Gammaproteobacteria,3XMF8@561|Escherichia 1236|Gammaproteobacteria M Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division (By similarity) mltD GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0008150,GO:0008932,GO:0008933,GO:0009893,GO:0016020,GO:0016740,GO:0016757,GO:0019222,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043085,GO:0044093,GO:0044464,GO:0048518,GO:0050789,GO:0050790,GO:0051341,GO:0051353,GO:0061783,GO:0065007,GO:0065009 - ko:K08307 - - - - ko00000,ko01000,ko01011 - - - LysM,SLT k59_1793813_2 316407.4902947 1.17e-46 154.0 COG0500@1|root,COG2226@2|Bacteria,1PN45@1224|Proteobacteria,1RP4K@1236|Gammaproteobacteria,3XNY0@561|Escherichia 1236|Gammaproteobacteria Q S-adenosylmethionine-dependent methyltransferase activity yafE GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0008168,GO:0008757,GO:0016740,GO:0016741,GO:0032259,GO:0044424,GO:0044464 - - - - - - - - - - Methyltransf_11,Methyltransf_25 k59_614637_1 702113.PP1Y_AT36222 1.26e-158 461.0 COG3131@1|root,COG3131@2|Bacteria,1MUNX@1224|Proteobacteria,2TRU1@28211|Alphaproteobacteria,2K0G2@204457|Sphingomonadales 204457|Sphingomonadales P Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) - - - ko:K03670 - - - - ko00000 - - - MdoG k59_1518813_1 1229909.NSED_00185 3.48e-80 248.0 COG0484@1|root,arCOG02846@2157|Archaea,41SCZ@651137|Thaumarchaeota 651137|Thaumarchaeota O DnaJ central domain - - - ko:K03686 - - - - ko00000,ko03029,ko03110 - - - DnaJ,DnaJ_C,DnaJ_CXXCXGXG k59_274824_1 1056820.KB900636_gene899 3.96e-77 255.0 COG1472@1|root,COG1472@2|Bacteria,1MVIV@1224|Proteobacteria,1RMA0@1236|Gammaproteobacteria,2PMR7@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria G Glycosyl hydrolase family 3 C-terminal domain - - 3.2.1.21 ko:K05349 ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110 - R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040 RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248 ko00000,ko00001,ko01000 - GH3 - Glyco_hydro_3,Glyco_hydro_3_C k59_551542_1 1236494.BAJN01000006_gene1073 6.26e-18 87.8 COG1216@1|root,COG1216@2|Bacteria,4NFW5@976|Bacteroidetes,2FQ14@200643|Bacteroidia 976|Bacteroidetes S Glycosyltransferase, group 2 family protein wbbL - - ko:K07011 - - - - ko00000 - - - Glyco_tranf_2_3,Glyco_trans_2_3,Glycos_transf_2 k59_1742757_1 436308.Nmar_0709 9.58e-78 237.0 COG0778@1|root,arCOG00288@2157|Archaea,41T1J@651137|Thaumarchaeota 651137|Thaumarchaeota C PFAM Nitroreductase - - - - - - - - - - - - Nitroreductase k59_668137_1 395963.Bind_0797 1.25e-59 195.0 COG0265@1|root,COG0265@2|Bacteria,1MURF@1224|Proteobacteria,2TUVW@28211|Alphaproteobacteria,3NC01@45404|Beijerinckiaceae 28211|Alphaproteobacteria O Domain present in PSD-95, Dlg, and ZO-1/2. MA20_20705 - - - - - - - - - - - PDZ_2,Trypsin_2 k59_50557_1 436308.Nmar_1645 2.04e-64 199.0 COG3398@1|root,arCOG02611@2157|Archaea,41T7Q@651137|Thaumarchaeota 651137|Thaumarchaeota K Winged helix-turn-helix DNA-binding - - - - - - - - - - - - HTH_24 k59_50557_2 436308.Nmar_1646 1.87e-53 171.0 arCOG07573@1|root,arCOG07573@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_50557_3 1229909.NSED_08915 7.98e-20 90.1 arCOG08793@1|root,arCOG08812@1|root,arCOG08793@2157|Archaea,arCOG08812@2157|Archaea,41T0K@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_950016_1 357244.OTBS_1787 1.82e-06 50.4 COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,1P76X@1224|Proteobacteria,2U16U@28211|Alphaproteobacteria,47FJ1@766|Rickettsiales 766|Rickettsiales L DDE superfamily endonuclease - - - ko:K07494 - - - - ko00000 - - - DDE_3,HTH_Tnp_IS630 k59_899240_1 998674.ATTE01000001_gene1949 2.23e-108 321.0 COG0057@1|root,COG0057@2|Bacteria,1MU93@1224|Proteobacteria,1RMBM@1236|Gammaproteobacteria,4601Z@72273|Thiotrichales 72273|Thiotrichales G Belongs to the glyceraldehyde-3-phosphate dehydrogenase family - - 1.2.1.12 ko:K00134 ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01061 RC00149 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - Gp_dh_C,Gp_dh_N k59_106600_1 1123037.AUDE01000001_gene1859 5.13e-26 109.0 COG0308@1|root,COG0308@2|Bacteria,4NG5Q@976|Bacteroidetes,1HYK9@117743|Flavobacteriia 976|Bacteroidetes E peptidase M1 pepN1 - 3.4.11.2 ko:K01256 ko00480,ko01100,map00480,map01100 - R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 - - - Peptidase_M1 k59_497292_1 1125863.JAFN01000001_gene3487 2.95e-80 244.0 COG0410@1|root,COG0410@2|Bacteria,1R9AG@1224|Proteobacteria,42KZN@68525|delta/epsilon subdivisions,2WJWX@28221|Deltaproteobacteria 28221|Deltaproteobacteria E ABC-type branched-chain amino acid transport systems ATPase component - - - ko:K01996 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - ABC_tran k59_1742774_1 1122137.AQXF01000005_gene1284 1.25e-114 342.0 COG1473@1|root,COG1473@2|Bacteria,1MUIV@1224|Proteobacteria,2TR5B@28211|Alphaproteobacteria 28211|Alphaproteobacteria S amidohydrolase - - - - - - - - - - - - M20_dimer,Peptidase_M20 k59_441944_1 1121937.AUHJ01000007_gene1835 3.4e-85 256.0 COG1309@1|root,COG1309@2|Bacteria,1R52P@1224|Proteobacteria,1S4A4@1236|Gammaproteobacteria,468EM@72275|Alteromonadaceae 1236|Gammaproteobacteria K COG1309 Transcriptional regulator - - - - - - - - - - - - TetR,TetR_N k59_1407930_1 194867.ALBQ01000023_gene3222 3.67e-104 316.0 COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,2TS7G@28211|Alphaproteobacteria,2K0YK@204457|Sphingomonadales 204457|Sphingomonadales S ABC transporter - - - - - - - - - - - - ABC_tran,ABC_tran_Xtn k59_1577779_1 1122212.AULO01000008_gene1369 1.51e-25 106.0 COG1530@1|root,COG1530@2|Bacteria,1MV65@1224|Proteobacteria,1RMIW@1236|Gammaproteobacteria,1XI2S@135619|Oceanospirillales 135619|Oceanospirillales J Involved in the processing of the 5'end of 16S rRNA - - - ko:K08301 - - - - ko00000,ko01000,ko03009,ko03019 - - - RNase_E_G,S1 k59_1577779_2 1415778.JQMM01000001_gene191 5.08e-13 73.2 COG3164@1|root,COG3164@2|Bacteria,1MXWF@1224|Proteobacteria,1RNUK@1236|Gammaproteobacteria,1J4SY@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Protein of unknown function yhdP GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0030288,GO:0030313,GO:0031224,GO:0031226,GO:0031975,GO:0042597,GO:0044425,GO:0044459,GO:0044464,GO:0071944 - - - - - - - - - - AsmA_2,DUF3971 k59_391057_1 1122194.AUHU01000010_gene3068 1.1e-106 337.0 COG0458@1|root,COG0458@2|Bacteria,1MUDZ@1224|Proteobacteria,1RPIU@1236|Gammaproteobacteria,46439@72275|Alteromonadaceae 1236|Gammaproteobacteria F COG0458 Carbamoylphosphate synthase large subunit (split gene in MJ) carB GO:0000050,GO:0000166,GO:0003674,GO:0003824,GO:0004087,GO:0004088,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005951,GO:0006082,GO:0006139,GO:0006206,GO:0006220,GO:0006221,GO:0006520,GO:0006525,GO:0006526,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016053,GO:0016597,GO:0016874,GO:0016879,GO:0016884,GO:0017076,GO:0018130,GO:0019438,GO:0019627,GO:0019637,GO:0019693,GO:0019752,GO:0019856,GO:0030554,GO:0031406,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046112,GO:0046390,GO:0046394,GO:0046483,GO:0046872,GO:0055086,GO:0071704,GO:0071941,GO:0072527,GO:0072528,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494 6.3.5.5 ko:K01955 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - iAF1260.b0033,iBWG_1329.BWG_0031,iECDH10B_1368.ECDH10B_0034,iECDH1ME8569_1439.ECDH1ME8569_0031,iECUMN_1333.ECUMN_0034,iEcDH1_1363.EcDH1_3566,iJN746.PP_4723,iJO1366.b0033,iJR904.b0033,iPC815.YPO0482,iY75_1357.Y75_RS00170,iYL1228.KPN_00041 CPSase_L_D2,CPSase_L_D3,MGS k59_50591_1 1122137.AQXF01000002_gene160 2.75e-105 319.0 COG0504@1|root,COG0504@2|Bacteria,1MUIT@1224|Proteobacteria,2TS4Y@28211|Alphaproteobacteria 28211|Alphaproteobacteria F Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates pyrG - 6.3.4.2 ko:K01937 ko00240,ko01100,map00240,map01100 M00052 R00571,R00573 RC00010,RC00074 ko00000,ko00001,ko00002,ko01000 - - - CTP_synth_N,GATase k59_1685764_1 1499967.BAYZ01000048_gene2700 3.16e-52 191.0 COG2211@1|root,COG2211@2|Bacteria 2|Bacteria G Major facilitator Superfamily - - - ko:K03292 - - - - ko00000 2.A.2 - - MFS_2,MFS_3 k59_1005720_1 941449.dsx2_2923 8.89e-28 116.0 COG5002@1|root,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,43CS7@68525|delta/epsilon subdivisions,2X7ZW@28221|Deltaproteobacteria,2MHC1@213115|Desulfovibrionales 28221|Deltaproteobacteria T histidine kinase HAMP region domain protein - - - - - - - - - - - - HAMP,HATPase_c,HisKA,PAS,PAS_9,Response_reg,SBP_bac_3,sCache_3_2 k59_899264_1 1150469.RSPPHO_02648 8.38e-110 322.0 COG0074@1|root,COG0074@2|Bacteria,1MUGA@1224|Proteobacteria,2TQKB@28211|Alphaproteobacteria,2JPJ9@204441|Rhodospirillales 204441|Rhodospirillales C Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit sucD - 6.2.1.5 ko:K01902 ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374,M00620 R00405,R02404 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000 - - - CoA_binding,Ligase_CoA k59_1742794_1 1229909.NSED_02705 6.17e-90 275.0 COG3635@1|root,arCOG01696@2157|Archaea,41S6M@651137|Thaumarchaeota 651137|Thaumarchaeota G phosphoglycerate mutase - - 5.4.2.12 ko:K15635 ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003 R01518 RC00536 ko00000,ko00001,ko00002,ko01000 - - - Metalloenzyme,PhosphMutase k59_1742794_2 436308.Nmar_0536 6.08e-93 275.0 COG1547@1|root,arCOG03705@2157|Archaea,41SQ0@651137|Thaumarchaeota 651137|Thaumarchaeota S Domain of unknown function (DUF309) - - - ko:K09763 - - - - ko00000 - - - DUF309 k59_106642_1 595460.RRSWK_03256 6.52e-92 289.0 COG0518@1|root,COG0519@1|root,COG0518@2|Bacteria,COG0519@2|Bacteria,2IX19@203682|Planctomycetes 203682|Planctomycetes F Catalyzes the synthesis of GMP from XMP guaA GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046037,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 6.3.5.2 ko:K01951 ko00230,ko00983,ko01100,map00230,map00983,map01100 M00050 R01230,R01231,R08244 RC00010,RC00204 ko00000,ko00001,ko00002,ko01000,ko01002 - - - GATase,GMP_synt_C,NAD_synthase k59_106642_2 889378.Spiaf_1610 1.46e-05 46.2 COG0516@1|root,COG0516@2|Bacteria,2J5K7@203691|Spirochaetes 203691|Spirochaetes F Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides guaB - 1.1.1.205 ko:K00088 ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 M00050 R01130,R08240 RC00143,RC02207 ko00000,ko00001,ko00002,ko01000,ko04147 - - - CBS,IMPDH k59_497314_1 1122137.AQXF01000004_gene1679 6.26e-18 80.9 COG0031@1|root,COG0031@2|Bacteria,1MUBE@1224|Proteobacteria,2TS33@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Cysteine synthase cysK - 2.5.1.47 ko:K01738 ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230 M00021 R00897,R03601,R04859 RC00020,RC02814,RC02821 ko00000,ko00001,ko00002,ko01000 - - - PALP k59_497314_2 1122137.AQXF01000004_gene1678 7.8e-131 378.0 COG1045@1|root,COG1045@2|Bacteria,1MVFX@1224|Proteobacteria,2TTNU@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Bacterial transferase hexapeptide (six repeats) srpH - 2.3.1.30 ko:K00640 ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111 M00021 R00586 RC00004,RC00041 ko00000,ko00001,ko00002,ko01000 - - - Hexapep,SATase_N k59_838983_1 234267.Acid_2611 3.61e-12 72.4 COG0577@1|root,COG0577@2|Bacteria 2|Bacteria V efflux transmembrane transporter activity - - - - - - - - - - - - FtsX,MacB_PCD k59_1067041_2 656024.FsymDg_0476 4.61e-78 249.0 COG1408@1|root,COG1408@2|Bacteria,2I2EP@201174|Actinobacteria 201174|Actinobacteria S metallophosphoesterase - - - - - - - - - - - - Metallophos k59_1005736_1 565045.NOR51B_2044 1.47e-123 366.0 COG1008@1|root,COG1008@2|Bacteria,1MV7V@1224|Proteobacteria,1RNI4@1236|Gammaproteobacteria,1J5MF@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C NADH ubiquinone oxidoreductase subunit nuoM GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015672,GO:0015980,GO:0015988,GO:0015990,GO:0016020,GO:0016021,GO:0030964,GO:0031224,GO:0031226,GO:0032991,GO:0034220,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0045333,GO:0048037,GO:0048038,GO:0048039,GO:0051179,GO:0051234,GO:0055085,GO:0055114,GO:0070469,GO:0070470,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1902600,GO:1990204 1.6.5.3 ko:K00342 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - iSDY_1059.SDY_2473 Proton_antipo_M k59_106652_1 765911.Thivi_2083 1.49e-213 603.0 COG0804@1|root,COG0804@2|Bacteria,1MU5P@1224|Proteobacteria,1RN78@1236|Gammaproteobacteria,1WWPQ@135613|Chromatiales 135613|Chromatiales E Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family ureC - 3.5.1.5 ko:K01428 ko00220,ko00230,ko00791,ko01100,ko01120,ko05120,map00220,map00230,map00791,map01100,map01120,map05120 - R00131 RC02798,RC02806 ko00000,ko00001,ko01000 - - - Amidohydro_1,Urease_alpha k59_899273_1 1229909.NSED_07605 8.71e-79 236.0 arCOG08703@1|root,arCOG08703@2157|Archaea,41SS0@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_50619_1 1122137.AQXF01000005_gene1192 1.86e-66 216.0 COG2271@1|root,COG2271@2|Bacteria,1MWYR@1224|Proteobacteria,2TSXW@28211|Alphaproteobacteria 28211|Alphaproteobacteria G Major facilitator Superfamily - - - - - - - - - - - - MFS_1 k59_1119801_1 1448139.AI20_11700 1.74e-84 277.0 COG0479@1|root,COG0674@1|root,COG1013@1|root,COG1014@1|root,COG0479@2|Bacteria,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,1MVM0@1224|Proteobacteria,1RNNX@1236|Gammaproteobacteria,1Y4PX@135624|Aeromonadales 135624|Aeromonadales C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin - - 1.2.7.1 ko:K03737 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00173,M00307 R01196,R10866 RC00004,RC02742 br01601,ko00000,ko00001,ko00002,ko01000 - - - EKR,Fer4,PFOR_II,POR,POR_N,TPP_enzyme_C k59_1520260_1 1415778.JQMM01000001_gene2132 2.85e-115 341.0 COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,1RN5B@1236|Gammaproteobacteria,1J5DQ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E COG0436 Aspartate tyrosine aromatic aminotransferase alaA GO:0003674,GO:0003824,GO:0004021,GO:0005488,GO:0006082,GO:0006090,GO:0006520,GO:0006522,GO:0006523,GO:0006807,GO:0006950,GO:0006974,GO:0008144,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009058,GO:0009078,GO:0009079,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0019272,GO:0019752,GO:0019842,GO:0030170,GO:0030632,GO:0032787,GO:0033554,GO:0036094,GO:0042221,GO:0042851,GO:0042852,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046144,GO:0046145,GO:0046394,GO:0046416,GO:0046436,GO:0046437,GO:0046677,GO:0047635,GO:0048037,GO:0050662,GO:0050896,GO:0051716,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.6.1.2,2.6.1.66 ko:K14260 ko00220,ko00250,ko00290,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00290,map01100,map01110,map01130,map01210,map01230 - R00258,R01215 RC00006,RC00008,RC00036 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_1_2 k59_552972_1 1124780.ANNU01000072_gene1069 1.24e-56 178.0 COG2865@1|root,COG2865@2|Bacteria,4NTCY@976|Bacteroidetes,47Y9B@768503|Cytophagia 976|Bacteroidetes K Domain of unknown function (DUF4062) - - - - - - - - - - - - DUF4062 k59_333844_1 1123008.KB905711_gene816 3.21e-12 70.1 COG0842@1|root,COG0842@2|Bacteria,4NDU0@976|Bacteroidetes,2FMJ3@200643|Bacteroidia,22WTM@171551|Porphyromonadaceae 976|Bacteroidetes V Transport permease protein ybhS - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_3 k59_333844_2 1304275.C41B8_10615 1.94e-64 213.0 COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,1RMM4@1236|Gammaproteobacteria 1236|Gammaproteobacteria V (ABC) transporter ybhF GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006855,GO:0008150,GO:0015562,GO:0015893,GO:0016020,GO:0022857,GO:0042221,GO:0042493,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071944 - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_552973_1 1286631.X805_17540 1.28e-26 108.0 COG0543@1|root,COG0633@1|root,COG0543@2|Bacteria,COG0633@2|Bacteria,1MXPX@1224|Proteobacteria,2VI2P@28216|Betaproteobacteria,1KMYH@119065|unclassified Burkholderiales 28216|Betaproteobacteria C Oxidoreductase FAD-binding domain - - 1.18.1.3 ko:K15765 ko00623,ko00920,ko01100,ko01120,ko01220,map00623,map00920,map01100,map01120,map01220 M00538 R02550,R03562,R05666,R09513 RC00269,RC00490,RC02556 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_6,Fer2,NAD_binding_1 k59_1234498_1 1079460.ATTQ01000070_gene4791 7.49e-37 139.0 COG1502@1|root,COG1502@2|Bacteria,1R4EZ@1224|Proteobacteria,2U0UJ@28211|Alphaproteobacteria,4BDC0@82115|Rhizobiaceae 28211|Alphaproteobacteria I PLD-like domain - - - - - - - - - - - - PLDc_2 k59_106667_1 472759.Nhal_0856 1.33e-62 200.0 COG2386@1|root,COG2386@2|Bacteria,1NJB0@1224|Proteobacteria,1RRFJ@1236|Gammaproteobacteria,1WWPG@135613|Chromatiales 135613|Chromatiales U Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes - - - ko:K02194 ko02010,map02010 M00259 - - ko00000,ko00001,ko00002,ko02000 3.A.1.107 - - CcmB k59_950098_1 604354.TSIB_1393 2.11e-39 149.0 COG0464@1|root,arCOG01308@2157|Archaea,2XSYR@28890|Euryarchaeota,243CC@183968|Thermococci 183968|Thermococci D Cell division protein 48 (CDC48) N-terminal domain - - - ko:K13525 ko04141,ko05134,map04141,map05134 M00400,M00403 - - ko00000,ko00001,ko00002,ko03019,ko04131,ko04147 3.A.16.1 - - AAA,CDC48_2,CDC48_N,Vps4_C k59_1520264_1 1548905.A0A0A1IWZ4_9CAUD 1.93e-16 85.1 4QAKM@10239|Viruses,4QPEF@28883|Caudovirales,4QKNE@10699|Siphoviridae 10699|Siphoviridae S DNA polymerase family A - GO:0003674,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0006139,GO:0006259,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008408,GO:0009058,GO:0009059,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0071704,GO:0071897,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901362,GO:1901576 - - - - - - - - - - - k59_899275_1 247634.GPB2148_813 0.000159 43.5 COG1231@1|root,COG1231@2|Bacteria,1QXX6@1224|Proteobacteria,1T3IZ@1236|Gammaproteobacteria,1J5KT@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E K COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit - - 1.5.99.6 ko:K00316 ko00330,ko00410,ko01100,map00330,map00410,map01100 - R01914,R01915 RC00053,RC00225 ko00000,ko00001,ko01000 - - - NAD_binding_8 k59_899275_2 247634.GPB2148_880 4.52e-50 164.0 COG3450@1|root,COG3450@2|Bacteria,1N21T@1224|Proteobacteria,1SBKQ@1236|Gammaproteobacteria,1JA60@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S enzyme of the cupin superfamily - - - ko:K06995 - - - - ko00000 - - - Cupin_3 k59_899275_3 983920.Y88_1308 0.000999 43.9 COG1574@1|root,COG1574@2|Bacteria,1MWP2@1224|Proteobacteria,2TTRU@28211|Alphaproteobacteria,2K03D@204457|Sphingomonadales 204457|Sphingomonadales S PFAM amidohydrolase - - - - - - - - - - - - Amidohydro_3 k59_668211_1 216595.PFLU_1865 1.99e-31 125.0 COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,1RPM5@1236|Gammaproteobacteria,1YM7G@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria I dehydrogenase fadE - - ko:K06445 ko00071,ko01100,ko01212,map00071,map01100,map01212 M00087 R01175,R01279,R03777,R03857,R03990,R04751,R04754 RC00052,RC00076 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N,DUF1974 k59_729381_1 945543.VIBR0546_16728 9.31e-63 206.0 COG0579@1|root,COG0579@2|Bacteria,1N0QB@1224|Proteobacteria,1RN24@1236|Gammaproteobacteria,1XTAP@135623|Vibrionales 135623|Vibrionales S Hydroxyglutarate oxidase - - - ko:K15736 - - - - ko00000,ko01000 - - - DAO k59_1520285_1 1366050.N234_33750 1.02e-12 72.8 COG1960@1|root,COG1960@2|Bacteria,1MX17@1224|Proteobacteria,2VM2C@28216|Betaproteobacteria,1K3BN@119060|Burkholderiaceae 28216|Betaproteobacteria I acyl-CoA dehydrogenase - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_1795202_1 186497.PF1421 2.25e-61 204.0 COG0160@1|root,arCOG00915@2157|Archaea,2Y83J@28890|Euryarchaeota,2431R@183968|Thermococci 183968|Thermococci E Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family - - 2.6.1.19 ko:K00823 ko00250,ko00410,ko00640,ko00650,ko01100,ko01120,map00250,map00410,map00640,map00650,map01100,map01120 M00027 R00908,R01648 RC00006,RC00062 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 k59_333857_2 1226322.HMPREF1545_02166 2.18e-15 77.4 COG3836@1|root,COG3836@2|Bacteria,1UZZG@1239|Firmicutes,24DTX@186801|Clostridia 186801|Clostridia G Belongs to the HpcH HpaI aldolase family - - 4.1.2.52 ko:K02510 ko00350,ko01120,map00350,map01120 - R01645,R01647 RC00307,RC00572,RC00574,RC03057 ko00000,ko00001,ko01000 - - - HpcH_HpaI k59_1795203_2 436308.Nmar_0973 6.56e-12 64.7 arCOG08728@1|root,arCOG08728@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_668229_1 1046724.KB889851_gene2238 6.85e-29 116.0 COG2304@1|root,COG2304@2|Bacteria,1MXQ7@1224|Proteobacteria,1RMDX@1236|Gammaproteobacteria,464NT@72275|Alteromonadaceae 1236|Gammaproteobacteria S protein containing a von Willebrand factor type A (vWA) domain - - - ko:K07114 - - - - ko00000,ko02000 1.A.13.2.2,1.A.13.2.3 - - VWA k59_899307_1 1454202.PPBDW_110068___1 1.53e-33 122.0 COG2969@1|root,COG2969@2|Bacteria,1MZ2Q@1224|Proteobacteria,1S8WT@1236|Gammaproteobacteria,1XWV9@135623|Vibrionales 135623|Vibrionales S stringent starvation protein b sspB - - ko:K03600 - - - - ko00000,ko03021 - - - SspB k59_1119825_1 1122137.AQXF01000005_gene1324 8.76e-48 165.0 COG0614@1|root,COG0614@2|Bacteria,1RDZS@1224|Proteobacteria,2U6ZU@28211|Alphaproteobacteria 28211|Alphaproteobacteria P abc-type fe3 -hydroxamate transport system, periplasmic component - - - ko:K02016 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko02000 3.A.1.14 - - Peripla_BP_2 k59_1630565_1 251221.35210715 3.03e-70 222.0 COG3039@1|root,COG3039@2|Bacteria,1G1EK@1117|Cyanobacteria 1117|Cyanobacteria L PFAM Transposase DDE domain - - - - - - - - - - - - DDE_Tnp_1_3 k59_1520318_1 1121921.KB898706_gene2752 2.13e-23 98.6 COG2854@1|root,COG2854@2|Bacteria,1PC5P@1224|Proteobacteria,1SWZX@1236|Gammaproteobacteria,2PNY2@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria Q MlaC protein - - - ko:K07323 ko02010,map02010 M00210 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27.3 - - MlaC k59_218286_1 525909.Afer_0951 3.9e-44 160.0 COG0013@1|root,COG0013@2|Bacteria,2GIUG@201174|Actinobacteria,4CMTK@84992|Acidimicrobiia 84992|Acidimicrobiia J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain alaS - 6.1.1.7 ko:K01872 ko00970,map00970 M00359,M00360 R03038 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DHHA1,tRNA-synt_2c,tRNA_SAD k59_1005795_1 452637.Oter_1728 2.17e-46 166.0 COG0642@1|root,COG2205@2|Bacteria,46TKR@74201|Verrucomicrobia,3K7YS@414999|Opitutae 452637.Oter_1728|- T histidine kinase HAMP region domain protein - - - - - - - - - - - - - k59_50660_1 323848.Nmul_A1150 8.14e-85 278.0 COG0493@1|root,COG0543@1|root,COG0493@2|Bacteria,COG0543@2|Bacteria,1PV5D@1224|Proteobacteria,2WB3J@28216|Betaproteobacteria,37281@32003|Nitrosomonadales 28216|Betaproteobacteria CEH PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase - - - - - - - - - - - - Pyr_redox_2 k59_1345371_1 1121924.ATWH01000014_gene3365 2.21e-05 45.8 COG1804@1|root,COG1804@2|Bacteria,2GIU7@201174|Actinobacteria,4FM14@85023|Microbacteriaceae 201174|Actinobacteria C CoA-transferase family III - - - - - - - - - - - - CoA_transf_3 k59_1345371_2 1419583.V466_30235 3.17e-46 153.0 COG0346@1|root,COG0346@2|Bacteria,1RH3J@1224|Proteobacteria,1S60C@1236|Gammaproteobacteria,1YTNJ@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria E Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - - - - - - - - - - Glyoxalase k59_1067078_1 398525.KB900701_gene6821 1.03e-56 186.0 COG1013@1|root,COG1013@2|Bacteria,1R5BF@1224|Proteobacteria,2TR4R@28211|Alphaproteobacteria,3JTAE@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria C Thiamine pyrophosphate enzyme, C-terminal TPP binding domain MA20_01040 - 1.2.7.11,1.2.7.3 ko:K00175 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - PFO_beta_C,TPP_enzyme_C k59_1067078_2 1121904.ARBP01000004_gene791 1.84e-17 82.4 COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,4NEP3@976|Bacteroidetes,47KM5@768503|Cytophagia 976|Bacteroidetes C Pyruvate ferredoxin/flavodoxin oxidoreductase - - 1.2.7.11,1.2.7.3 ko:K00174 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - POR,POR_N k59_1005804_1 1125863.JAFN01000001_gene308 1.04e-85 278.0 COG0046@1|root,COG0046@2|Bacteria,1MYN4@1224|Proteobacteria,42M08@68525|delta/epsilon subdivisions,2WITS@28221|Deltaproteobacteria 28221|Deltaproteobacteria F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL purL - 6.3.5.3 ko:K01952 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04463 RC00010,RC01160 ko00000,ko00001,ko00002,ko01000 - - - AIRS,AIRS_C,PurS k59_553021_1 323261.Noc_0118 1.31e-57 196.0 COG1253@1|root,COG1253@2|Bacteria,1MV3P@1224|Proteobacteria,1T1MS@1236|Gammaproteobacteria,1WX38@135613|Chromatiales 135613|Chromatiales P CBS domain - - - ko:K03699 - - - - ko00000,ko02042 - - - CBS,CorC_HlyC,DUF21 k59_50671_1 1122137.AQXF01000001_gene2647 2.36e-33 120.0 COG2346@1|root,COG2346@2|Bacteria,1N005@1224|Proteobacteria,2U8PT@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Bacterial-like globin - - - ko:K06886 - - - - ko00000 - - - Bac_globin k59_50671_2 314260.PB2503_01897 1.89e-19 86.3 28JGK@1|root,2Z9AA@2|Bacteria,1MWFY@1224|Proteobacteria,2U3RX@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Protein of unknown function (DUF3034) - - - - - - - - - - - - DUF3034 k59_779510_1 316407.85675408 6.39e-134 388.0 COG3192@1|root,COG3192@2|Bacteria,1NPK6@1224|Proteobacteria,1S0MH@1236|Gammaproteobacteria 1236|Gammaproteobacteria E ethanolamine utilization protein eutH GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K04023 - - - - ko00000 - - - EutH k59_1234572_1 1122137.AQXF01000004_gene1783 4.04e-61 198.0 COG0834@1|root,COG0834@2|Bacteria 2|Bacteria ET amino acid transport - - - ko:K02030 - M00236 - - ko00000,ko00002,ko02000 3.A.1.3 - - SBP_bac_3 k59_50683_1 1123257.AUFV01000003_gene1059 3.02e-66 207.0 COG0703@1|root,COG0703@2|Bacteria,1MUFJ@1224|Proteobacteria,1RPF6@1236|Gammaproteobacteria,1X6GJ@135614|Xanthomonadales 135614|Xanthomonadales F Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate aroK GO:0000287,GO:0003674,GO:0003824,GO:0004765,GO:0005488,GO:0006082,GO:0006520,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019438,GO:0019632,GO:0019752,GO:0032787,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046872,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615 2.7.1.71 ko:K00891 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02412 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - SKI k59_1130323_1 1056512.D515_04314 3.42e-21 95.1 COG1271@1|root,COG1271@2|Bacteria,1MV60@1224|Proteobacteria,1RN2U@1236|Gammaproteobacteria,1XUQZ@135623|Vibrionales 135623|Vibrionales C Cytochrome bd terminal oxidase subunit I - - 1.10.3.14 ko:K00425 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00153 R11325 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.4.3 - - Cyt_bd_oxida_I k59_1130323_2 365046.Rta_25150 1.09e-30 117.0 COG1294@1|root,COG1294@2|Bacteria,1MURP@1224|Proteobacteria,2VHSQ@28216|Betaproteobacteria,4AD1I@80864|Comamonadaceae 28216|Betaproteobacteria C cytochrome d ubiquinol oxidase, subunit II cydB - 1.10.3.14 ko:K00426 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00153 R11325 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.4.3 - - Cyt_bd_oxida_II k59_226271_1 686578.AFFX01000001_gene1272 8.75e-42 146.0 COG0546@1|root,COG0546@2|Bacteria,1RCXJ@1224|Proteobacteria,1S3VU@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Phosphoglycolate phosphatase gph GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006022,GO:0006040,GO:0006082,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008967,GO:0009254,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019752,GO:0030203,GO:0033554,GO:0034641,GO:0042578,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044260,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097172,GO:1901135,GO:1901360,GO:1901564 3.1.3.105,3.1.3.18 ko:K01091,ko:K22292 ko00520,ko00630,ko01100,ko01110,ko01130,map00520,map00630,map01100,map01110,map01130 - R01334,R11785 RC00017 ko00000,ko00001,ko01000 - - - HAD_2 k59_395763_1 68219.JNXI01000007_gene1834 4.13e-07 57.0 COG3214@1|root,COG3214@2|Bacteria,2GK0T@201174|Actinobacteria 201174|Actinobacteria S Winged helix DNA-binding domain - - - - - - - - - - - - HTH_42 k59_1356247_1 13690.CP98_01372 1.02e-92 290.0 COG3182@1|root,COG3182@2|Bacteria,1MVET@1224|Proteobacteria,2TVHW@28211|Alphaproteobacteria,2K0UQ@204457|Sphingomonadales 204457|Sphingomonadales S PepSY-associated TM region - - - - - - - - - - - - PepSY_TM k59_395764_1 335543.Sfum_0548 4.7e-10 62.0 COG1619@1|root,COG1619@2|Bacteria,1MWIY@1224|Proteobacteria,42Q52@68525|delta/epsilon subdivisions,2WJ3S@28221|Deltaproteobacteria,2MRUW@213462|Syntrophobacterales 28221|Deltaproteobacteria V LD-carboxypeptidase - - 3.4.17.13 ko:K01297 - - - - ko00000,ko01000,ko01002,ko01011 - - - Peptidase_S66 k59_395764_2 565045.NOR51B_489 5.57e-25 103.0 COG0305@1|root,COG0305@2|Bacteria,1MUG9@1224|Proteobacteria,1RPM2@1236|Gammaproteobacteria,1J4Z9@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins dnaB GO:0003674,GO:0003678,GO:0003824,GO:0004386,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006268,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009628,GO:0009987,GO:0010212,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0032392,GO:0032508,GO:0034641,GO:0034645,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051276,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360,GO:1901576 3.6.4.12 ko:K02314 ko03030,ko04112,map03030,map04112 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB,DnaB_C k59_1469291_1 439235.Dalk_1965 3.26e-22 103.0 COG4191@1|root,COG4191@2|Bacteria,1QUMH@1224|Proteobacteria,42MM2@68525|delta/epsilon subdivisions,2WJBF@28221|Deltaproteobacteria,2MHM2@213118|Desulfobacterales 28221|Deltaproteobacteria T PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - HATPase_c,HisKA k59_734869_1 1049564.TevJSym_cz00010 4.47e-167 474.0 COG3177@1|root,COG3177@2|Bacteria,1MV69@1224|Proteobacteria,1RM9J@1236|Gammaproteobacteria,1J5EA@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Domain of unknown function (DUF4172) - - - - - - - - - - - - DUF4172,Fic k59_1638737_1 99598.Cal7507_5114 2.19e-18 79.3 COG0236@1|root,COG0236@2|Bacteria,1G9GC@1117|Cyanobacteria,1HP8R@1161|Nostocales 1117|Cyanobacteria IQ Carrier of the growing fatty acid chain in fatty acid biosynthesis acpP GO:0000035,GO:0000036,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016053,GO:0019637,GO:0019752,GO:0019842,GO:0031177,GO:0032787,GO:0033218,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0044620,GO:0046394,GO:0046467,GO:0046493,GO:0048037,GO:0051192,GO:0071704,GO:0072330,GO:0072341,GO:0090407,GO:0140104,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 - ko:K02078 - - - - ko00000,ko00001 - - - PP-binding k59_847794_1 999141.GME_02059 3.01e-49 159.0 COG0360@1|root,COG0360@2|Bacteria,1RH82@1224|Proteobacteria,1S5VU@1236|Gammaproteobacteria,1XK6B@135619|Oceanospirillales 135619|Oceanospirillales J Binds together with S18 to 16S ribosomal RNA rpsF - - ko:K02990 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011,ko03029 - - - Ribosomal_S6 k59_847794_2 398578.Daci_4032 0.000109 43.9 COG0566@1|root,COG0566@2|Bacteria,1MWCM@1224|Proteobacteria,2VHF4@28216|Betaproteobacteria,4AAVB@80864|Comamonadaceae 28216|Betaproteobacteria J Specifically methylates the ribose of guanosine 2251 in 23S rRNA rlmB - 2.1.1.185 ko:K03218 - - - - ko00000,ko01000,ko03009 - - - SpoU_methylase,SpoU_sub_bind k59_113361_1 1121033.AUCF01000005_gene5222 6.19e-57 194.0 COG2068@1|root,COG2068@2|Bacteria,1MW0X@1224|Proteobacteria,2TR5D@28211|Alphaproteobacteria,2JPR6@204441|Rhodospirillales 204441|Rhodospirillales H Probable molybdopterin binding domain - - 2.7.7.76 ko:K07141 ko00790,map00790 - R11582 - ko00000,ko00001,ko01000 - - - NTP_transf_3 k59_791360_1 1411685.U062_02115 2.44e-102 332.0 COG0642@1|root,COG5001@1|root,COG2205@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1J56I@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T (GGDEF) domain - - - - - - - - - - - - DUF2222,EAL,GGDEF,HAMP,HATPase_c,HisKA,Hpt,PAS_4,Response_reg k59_395773_1 1122137.AQXF01000003_gene1869 1.94e-14 69.7 2EQ70@1|root,33HT9@2|Bacteria,1NIHT@1224|Proteobacteria,2UK3J@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_395773_2 1122137.AQXF01000003_gene1870 5.6e-38 142.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2TQT0@28211|Alphaproteobacteria 28211|Alphaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K03296 - - - - ko00000 2.A.6.2 - - ACR_tran k59_1243280_2 1120950.KB892708_gene4256 1.34e-89 285.0 COG0441@1|root,COG0441@2|Bacteria,2GKTC@201174|Actinobacteria,4DN38@85009|Propionibacteriales 201174|Actinobacteria J Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) thrS GO:0003674,GO:0003824,GO:0004812,GO:0004829,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006435,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.3 ko:K01868 ko00970,map00970 M00359,M00360 R03663 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,tRNA-synt_2b,tRNA_SAD k59_678286_1 1509405.GV67_00100 1.05e-55 189.0 2C4CB@1|root,2Z7XX@2|Bacteria,1R5NB@1224|Proteobacteria,2TVGN@28211|Alphaproteobacteria,4BJGY@82115|Rhizobiaceae 28211|Alphaproteobacteria L EcoRII C terminal - - - - - - - - - - - - EcoRII-C,EcoRII-N k59_678286_2 349966.DJ58_541 7.12e-29 108.0 COG3727@1|root,COG3727@2|Bacteria,1RH1C@1224|Proteobacteria,1S2V3@1236|Gammaproteobacteria,41HNT@629|Yersinia 1236|Gammaproteobacteria L DNA mismatch endonuclease Vsr vsr GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016788,GO:0033554,GO:0034641,GO:0043170,GO:0043765,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901363 - ko:K07458 - - - - ko00000,ko01000,ko03400 - - iB21_1397.ECBD_1686,iECD_1391.ECBD_1686 Vsr k59_335_1 1120971.AUCA01000006_gene2064 1.12e-35 135.0 COG0577@1|root,COG0577@2|Bacteria,1TPUU@1239|Firmicutes,4HATE@91061|Bacilli 91061|Bacilli V ABC-type antimicrobial peptide transport system, permease component macB1 - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_226300_1 1123508.JH636439_gene332 5.14e-07 56.6 COG2373@1|root,COG2931@1|root,COG3209@1|root,COG2373@2|Bacteria,COG2931@2|Bacteria,COG3209@2|Bacteria,2J3BU@203682|Planctomycetes 203682|Planctomycetes Q amine dehydrogenase activity - - - - - - - - - - - - - k59_904279_2 985255.APHJ01000025_gene1007 1.18e-05 53.9 COG0668@1|root,COG0668@2|Bacteria,4NJ1Q@976|Bacteroidetes,1HZHG@117743|Flavobacteriia 976|Bacteroidetes M Conserved TM helix - - - - - - - - - - - - TM_helix k59_1299875_2 502025.Hoch_3784 6.48e-38 144.0 COG1032@1|root,COG5011@1|root,COG1032@2|Bacteria,COG5011@2|Bacteria,1MV5G@1224|Proteobacteria,42MPT@68525|delta/epsilon subdivisions,2WJG9@28221|Deltaproteobacteria,2YUJ4@29|Myxococcales 28221|Deltaproteobacteria C SMART Elongator protein 3 MiaB NifB - - - - - - - - - - - - DUF2344,Radical_SAM k59_565435_1 1229909.NSED_04530 2.73e-101 305.0 COG0156@1|root,arCOG00113@2157|Archaea,41SAP@651137|Thaumarchaeota 651137|Thaumarchaeota E 8-amino-7-oxononanoate synthase - - 2.3.1.29 ko:K00639 ko00260,map00260 - R00371 RC00004,RC00394 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_1_2 k59_621799_1 1504672.669785010 3.2e-12 72.0 COG3266@1|root,COG3391@1|root,COG5297@1|root,COG3266@2|Bacteria,COG3391@2|Bacteria,COG5297@2|Bacteria,1QWRQ@1224|Proteobacteria 1224|Proteobacteria M 6-phosphogluconolactonase activity - - - - - - - - - - - - ASH,Abhydrolase_3,Cadherin-like,Cadherin_3,TIG,VCBS k59_565436_2 1234364.AMSF01000086_gene2826 5.72e-50 169.0 COG1595@1|root,COG1595@2|Bacteria,1R9WC@1224|Proteobacteria,1SA30@1236|Gammaproteobacteria,1X3FW@135614|Xanthomonadales 135614|Xanthomonadales K Belongs to the sigma-70 factor family. ECF subfamily - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 k59_395800_1 269799.Gmet_2759 1.1e-37 140.0 COG1683@1|root,COG3272@1|root,COG1683@2|Bacteria,COG3272@2|Bacteria,1MXYZ@1224|Proteobacteria,42M4E@68525|delta/epsilon subdivisions,2WKFT@28221|Deltaproteobacteria,43TH1@69541|Desulfuromonadales 28221|Deltaproteobacteria S Protein of unknown function (DUF1722) - - - - - - - - - - - - DUF1722,DUF523 k59_1243312_1 626887.J057_21275 1.14e-120 359.0 COG3119@1|root,COG3119@2|Bacteria,1MUJH@1224|Proteobacteria,1RN2V@1236|Gammaproteobacteria,465NQ@72275|Alteromonadaceae 1236|Gammaproteobacteria P Sulfatase - - 3.1.6.1 ko:K01130 ko00140,ko00600,map00140,map00600 - R03980,R04856 RC00128,RC00231 ko00000,ko00001,ko01000 - - - Sulfatase,Sulfatase_C k59_960822_1 330214.NIDE0998 6.19e-40 136.0 COG0440@1|root,COG0440@2|Bacteria,3J0K8@40117|Nitrospirae 40117|Nitrospirae E ACT domain - - 2.2.1.6 ko:K01653 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - ACT,ACT_5,ALS_ss_C k59_960822_2 330214.NIDE0999 6.42e-49 164.0 COG0059@1|root,COG0059@2|Bacteria,3J0DW@40117|Nitrospirae 40117|Nitrospirae H Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate ilvC - 1.1.1.86 ko:K00053 ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R03051,R04439,R04440,R05068,R05069,R05071 RC00726,RC00836,RC00837,RC01726 ko00000,ko00001,ko00002,ko01000 - - - IlvC,IlvN k59_565457_1 1288494.EBAPG3_30060 7.43e-86 262.0 COG0202@1|root,COG0202@2|Bacteria,1MU75@1224|Proteobacteria,2VHG6@28216|Betaproteobacteria,372HG@32003|Nitrosomonadales 28216|Betaproteobacteria K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoA GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006351,GO:0006354,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576 2.7.7.6 ko:K03040 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_A_CTD,RNA_pol_A_bac,RNA_pol_L k59_565457_2 292415.Tbd_0429 1.32e-37 131.0 COG0522@1|root,COG0522@2|Bacteria,1MW0U@1224|Proteobacteria,2VGZH@28216|Betaproteobacteria,1KS57@119069|Hydrogenophilales 119069|Hydrogenophilales J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit rpsD - - ko:K02986 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S4,S4 k59_1130413_1 1270193.JARP01000008_gene1291 7.21e-17 81.3 COG1446@1|root,COG1446@2|Bacteria,4NF1U@976|Bacteroidetes,1HXC4@117743|Flavobacteriia,2P02Z@237|Flavobacterium 976|Bacteroidetes E Asparaginase ybiK - 3.4.19.5,3.5.1.1 ko:K01424,ko:K13051 ko00250,ko00460,ko01100,ko01110,map00250,map00460,map01100,map01110 - R00485 RC00010,RC02798 ko00000,ko00001,ko01000,ko01002 - - - Asparaginase_2 k59_1130413_2 762376.AXYL_05224 5.35e-38 139.0 COG1028@1|root,COG1028@2|Bacteria,1MXWI@1224|Proteobacteria,2VJIU@28216|Betaproteobacteria,3T2XE@506|Alcaligenaceae 28216|Betaproteobacteria IQ KR domain - - - - - - - - - - - - adh_short_C2 k59_1638788_1 68570.DC74_1896 2.25e-53 181.0 COG0117@1|root,COG1985@1|root,COG0117@2|Bacteria,COG1985@2|Bacteria,2GKAX@201174|Actinobacteria 201174|Actinobacteria H Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate ribD - 1.1.1.193,3.5.4.26 ko:K11752 ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024 M00125 R03458,R03459 RC00204,RC00933 ko00000,ko00001,ko00002,ko01000 - - - RibD_C,dCMP_cyt_deam_1 k59_1695261_2 1504672.669786121 2.98e-14 74.7 COG1595@1|root,COG1595@2|Bacteria,1N00E@1224|Proteobacteria,2VQNP@28216|Betaproteobacteria,4ADI8@80864|Comamonadaceae 28216|Betaproteobacteria K Belongs to the sigma-70 factor family. ECF subfamily rpoE1 - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4,Sigma70_r4_2 k59_226344_1 1122137.AQXF01000002_gene588 7.39e-103 321.0 COG2366@1|root,COG2366@2|Bacteria,1MVMH@1224|Proteobacteria,2TS4D@28211|Alphaproteobacteria 28211|Alphaproteobacteria E COG2366 Protein related to penicillin acylase quiP - 3.5.1.11 ko:K01434 ko00311,ko01130,map00311,map01130 - R02170 RC00166,RC00328 ko00000,ko00001,ko01000,ko01002 - - - Penicil_amidase k59_452279_1 1122137.AQXF01000001_gene3019 1.55e-89 283.0 COG1185@1|root,COG1185@2|Bacteria,1MVB9@1224|Proteobacteria,2TRH3@28211|Alphaproteobacteria 28211|Alphaproteobacteria J Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction pnp GO:0000175,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004518,GO:0004527,GO:0004532,GO:0004540,GO:0004654,GO:0005488,GO:0006139,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008408,GO:0009056,GO:0009057,GO:0009892,GO:0009987,GO:0010468,GO:0010605,GO:0010629,GO:0016070,GO:0016071,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016796,GO:0016896,GO:0019222,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0060255,GO:0065007,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0097159,GO:0140098,GO:1901360,GO:1901361,GO:1901363,GO:1901575 2.7.7.8 ko:K00962 ko00230,ko00240,ko03018,map00230,map00240,map03018 M00394 R00437,R00438,R00439,R00440 RC02795 ko00000,ko00001,ko00002,ko01000,ko03016,ko03019 - - - KH_1,PNPase,RNase_PH,RNase_PH_C,S1 k59_1299916_1 876044.IMCC3088_2214 4.09e-06 50.4 COG4773@1|root,COG4773@2|Bacteria,1MWUQ@1224|Proteobacteria,1SJYF@1236|Gammaproteobacteria 1236|Gammaproteobacteria P COG1629 Outer membrane receptor proteins, mostly Fe transport - - - - - - - - - - - - Plug,TonB_dep_Rec k59_1299916_2 1042377.AFPJ01000008_gene1998 1.74e-32 119.0 COG3473@1|root,COG3473@2|Bacteria 2|Bacteria Q Maleate cis-trans isomerase - - 5.2.1.1 ko:K01799 ko00650,ko00760,ko01120,map00650,map00760,map01120 M00622 R01087 RC00448 ko00000,ko00001,ko00002,ko01000 - - - Asp_Glu_race k59_339456_1 439235.Dalk_1163 3.19e-42 152.0 COG0183@1|root,COG0183@2|Bacteria,1MUZV@1224|Proteobacteria,42ZT9@68525|delta/epsilon subdivisions,2WUUI@28221|Deltaproteobacteria,2MNC0@213118|Desulfobacterales 28221|Deltaproteobacteria H acetyl-coa acetyltransferase - - 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C k59_226354_1 330214.NIDE3282 1.08e-33 129.0 COG2319@1|root,COG2319@2|Bacteria 2|Bacteria S anaphase-promoting complex binding - - - - - - - - - - - - WD40 k59_904318_1 1469245.JFBG01000037_gene1851 6.58e-88 261.0 COG2030@1|root,COG2030@2|Bacteria,1MW4N@1224|Proteobacteria,1S43F@1236|Gammaproteobacteria 1236|Gammaproteobacteria I dehydratase - - 4.2.1.56 ko:K18290 ko00660,map00660 - R02491 RC00730 ko00000,ko00001,ko01000 - - - MaoC_dehydratas k59_1299931_1 1459636.NTE_01710 8.13e-37 125.0 arCOG10521@1|root,arCOG10521@2157|Archaea,41T8A@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1299931_2 1229909.NSED_02820 6.24e-86 253.0 arCOG08652@1|root,arCOG08652@2157|Archaea,41SMZ@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1695274_1 1122603.ATVI01000005_gene3304 1e-53 202.0 COG1629@1|root,COG4771@2|Bacteria,1MUWN@1224|Proteobacteria,1RN1E@1236|Gammaproteobacteria,1X417@135614|Xanthomonadales 135614|Xanthomonadales P receptor - - - - - - - - - - - - CarbopepD_reg_2,CarboxypepD_reg,Plug,TonB_dep_Rec k59_791459_1 880072.Desac_0098 6.79e-58 196.0 COG1208@1|root,COG1208@2|Bacteria,1MUYJ@1224|Proteobacteria,42MX5@68525|delta/epsilon subdivisions,2X5IB@28221|Deltaproteobacteria 28221|Deltaproteobacteria GJM COGs COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B gamma epsilon subunits (eIF-2Bgamma eIF-2Bepsilon) - - 2.7.7.13,5.4.2.8 ko:K16881 ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130 M00114,M00362 R00885,R01818 RC00002,RC00408 ko00000,ko00001,ko00002,ko01000 - - - Hexapep,NTP_transferase,PGM_PMM_I,PGM_PMM_II k59_1186854_1 1382356.JQMP01000001_gene892 7.35e-30 122.0 COG1165@1|root,COG1165@2|Bacteria,2G6JR@200795|Chloroflexi,27XZC@189775|Thermomicrobia 189775|Thermomicrobia H Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) menD - 2.2.1.9 ko:K02551 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116 R08165 RC02186 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M_2,TPP_enzyme_N k59_339474_1 316407.1742893 4.32e-156 443.0 COG1063@1|root,COG1063@2|Bacteria,1MV9A@1224|Proteobacteria,1RMNY@1236|Gammaproteobacteria,3XPEF@561|Escherichia 1236|Gammaproteobacteria E Catalyzes the NAD( )-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate ydjJ - 1.1.1.14,1.1.1.303,1.1.1.4,1.1.1.9 ko:K00004,ko:K00008,ko:K05351 ko00040,ko00051,ko00650,ko01100,map00040,map00051,map00650,map01100 M00014 R00875,R01896,R02855,R02946,R10504 RC00085,RC00102,RC00205,RC00525 ko00000,ko00001,ko00002,ko01000 - - - ADH_N,ADH_zinc_N k59_847870_1 643648.Slip_1857 1.32e-62 206.0 COG1660@1|root,COG1660@2|Bacteria,1TPS4@1239|Firmicutes,248KQ@186801|Clostridia,42JR5@68298|Syntrophomonadaceae 186801|Clostridia S Displays ATPase and GTPase activities yvcJ - - ko:K06958 - - - - ko00000,ko03019 - - - ATP_bind_2 k59_847870_2 1248760.ANFZ01000006_gene2843 1.88e-13 67.4 COG2893@1|root,COG2893@2|Bacteria,1RHH7@1224|Proteobacteria,2U9E5@28211|Alphaproteobacteria,2K4MZ@204457|Sphingomonadales 204457|Sphingomonadales G PTS fructose transporter subunit IIA - - 2.7.1.191 ko:K02793 ko00051,ko00520,ko01100,ko02060,map00051,map00520,map01100,map02060 M00276 R02630 RC00017,RC03206 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.6.1 - - EIIA-man k59_904330_1 1144275.COCOR_02357 1.77e-48 175.0 COG1020@1|root,COG1020@2|Bacteria,1QK4F@1224|Proteobacteria,42NH4@68525|delta/epsilon subdivisions,2WN7A@28221|Deltaproteobacteria,2YTZA@29|Myxococcales 28221|Deltaproteobacteria Q non-ribosomal peptide synthetase - - - ko:K16416 ko01052,map01052 - - - ko00000,ko00001,ko01008 - - - AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase k59_169929_1 991905.SL003B_2068 4.39e-63 197.0 COG0377@1|root,COG0377@2|Bacteria,1MUI2@1224|Proteobacteria,2TQK3@28211|Alphaproteobacteria,4BQ22@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoB GO:0003674,GO:0003824,GO:0003954,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0016655,GO:0050136,GO:0055114 1.6.5.3 ko:K00331 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q6 k59_169929_2 1122137.AQXF01000002_gene109 2.77e-76 228.0 COG0838@1|root,COG0838@2|Bacteria,1RGUT@1224|Proteobacteria,2U72Q@28211|Alphaproteobacteria 28211|Alphaproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoA GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 1.6.5.3 ko:K00330 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q4 k59_1073790_1 164757.Mjls_4777 1.19e-74 240.0 COG0028@1|root,COG0028@2|Bacteria,2GM6Y@201174|Actinobacteria,234PM@1762|Mycobacteriaceae 201174|Actinobacteria EH Belongs to the TPP enzyme family - - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_904331_1 337075.U4L3E9 9.69e-06 56.2 COG0642@1|root,KOG0519@2759|Eukaryota,391YN@33154|Opisthokonta,3NV7C@4751|Fungi,3QPHU@4890|Ascomycota 4751|Fungi T Histidine kinase CHK1 GO:0000155,GO:0000160,GO:0001932,GO:0001934,GO:0002831,GO:0002833,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006979,GO:0007154,GO:0007162,GO:0007165,GO:0008150,GO:0008152,GO:0009272,GO:0009365,GO:0009405,GO:0009607,GO:0009893,GO:0009966,GO:0009967,GO:0009987,GO:0010033,GO:0010562,GO:0010570,GO:0010604,GO:0010646,GO:0010647,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0018106,GO:0018193,GO:0018202,GO:0019220,GO:0019222,GO:0019538,GO:0022407,GO:0022408,GO:0023014,GO:0023051,GO:0023052,GO:0023056,GO:0030100,GO:0030155,GO:0030447,GO:0031323,GO:0031325,GO:0031399,GO:0031401,GO:0032268,GO:0032270,GO:0032872,GO:0032874,GO:0032879,GO:0032991,GO:0033554,GO:0033993,GO:0034599,GO:0035556,GO:0036180,GO:0036211,GO:0040007,GO:0040008,GO:0042221,GO:0042325,GO:0042327,GO:0042546,GO:0042710,GO:0043170,GO:0043408,GO:0043410,GO:0043412,GO:0043900,GO:0044010,GO:0044011,GO:0044085,GO:0044182,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044419,GO:0044424,GO:0044464,GO:0044764,GO:0045806,GO:0045927,GO:0045937,GO:0046677,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048583,GO:0048584,GO:0050764,GO:0050765,GO:0050789,GO:0050794,GO:0050896,GO:0051040,GO:0051042,GO:0051049,GO:0051051,GO:0051128,GO:0051129,GO:0051171,GO:0051173,GO:0051174,GO:0051246,GO:0051247,GO:0051703,GO:0051704,GO:0051716,GO:0060255,GO:0060627,GO:0061695,GO:0065007,GO:0070302,GO:0070304,GO:0070887,GO:0070994,GO:0071236,GO:0071310,GO:0071396,GO:0071554,GO:0071704,GO:0071840,GO:0071852,GO:0080090,GO:0080134,GO:0080135,GO:0090033,GO:0090605,GO:0090609,GO:0097305,GO:0097306,GO:0097307,GO:0097308,GO:0140096,GO:1900190,GO:1900231,GO:1900428,GO:1900430,GO:1900443,GO:1900445,GO:1901564,GO:1901700,GO:1901701,GO:1902494,GO:1902531,GO:1902533,GO:1902911,GO:1990234 2.7.13.3 ko:K19690 ko02020,map02020 M00516 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - AAA_16,GAF,GAF_2,HATPase_c,HisKA,Pkinase,Response_reg k59_1695287_1 1072685.IX83_08675 6.47e-68 211.0 COG0244@1|root,COG0244@2|Bacteria,1RAN5@1224|Proteobacteria,2VQ7A@28216|Betaproteobacteria,3T224@506|Alcaligenaceae 28216|Betaproteobacteria J Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors rplJ - - ko:K02864 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L10 k59_395847_1 253839.SSNG_07338 1.8e-34 130.0 COG1028@1|root,COG1028@2|Bacteria,2H0SM@201174|Actinobacteria 201174|Actinobacteria IQ Belongs to the short-chain dehydrogenases reductases (SDR) family - - - ko:K12420 ko00253,ko01056,ko01130,map00253,map01056,map01130 M00778 R06642,R09262,R09263,R09264 RC00029,RC00144 ko00000,ko00001,ko00002,ko01000,ko01004,ko01008 - - - adh_short k59_395847_2 1248760.ANFZ01000018_gene712 1.57e-06 53.5 COG0745@1|root,COG2199@1|root,COG5002@1|root,COG5278@1|root,COG0745@2|Bacteria,COG3706@2|Bacteria,COG5002@2|Bacteria,COG5278@2|Bacteria,1R7HC@1224|Proteobacteria,2TX5S@28211|Alphaproteobacteria,2KEH3@204457|Sphingomonadales 204457|Sphingomonadales T GAF domain - - - - - - - - - - - - CHASE3,GAF_2,HATPase_c,HisKA,Response_reg k59_57014_1 1112217.PPL19_06425 5.56e-14 67.0 COG2921@1|root,COG2921@2|Bacteria 2|Bacteria S Belongs to the UPF0250 family ybeD GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - ko:K09158 - - - - ko00000 - - - DUF493 k59_57014_2 7213.XP_004528281.1 4.53e-86 261.0 COG0321@1|root,KOG0325@2759|Eukaryota,396EP@33154|Opisthokonta,3CAT7@33208|Metazoa,3DS0T@33213|Bilateria,4285S@6656|Arthropoda,3SRK6@50557|Insecta 33208|Metazoa CH Biotin/lipoate A/B protein ligase family - - - - - - - - - - - - BPL_LplA_LipB k59_1469427_1 399795.CtesDRAFT_PD5133 3.76e-25 105.0 COG2801@1|root,COG2801@2|Bacteria,1R6QN@1224|Proteobacteria,2VKTM@28216|Betaproteobacteria,4ACM9@80864|Comamonadaceae 28216|Betaproteobacteria L Integrase, catalytic region - - - ko:K07497 - - - - ko00000 - - - rve,rve_3 k59_57016_1 436308.Nmar_0219 1.18e-71 225.0 arCOG08635@1|root,arCOG08635@2157|Archaea,41T54@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_226387_1 1249997.JHZW01000003_gene2199 3.36e-61 201.0 COG0318@1|root,COG0318@2|Bacteria,4NEXK@976|Bacteroidetes,1HX5P@117743|Flavobacteriia,2PGZY@252356|Maribacter 976|Bacteroidetes IQ AMP-binding enzyme menE - 6.2.1.26 ko:K01911 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116 R04030 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000 - - - AMP-binding,AMP-binding_C k59_226387_2 1121912.AUHD01000007_gene574 1.62e-19 89.4 COG4206@1|root,COG4206@2|Bacteria,4NZWU@976|Bacteroidetes,1I86Y@117743|Flavobacteriia 976|Bacteroidetes H TonB-linked outer membrane protein, SusC RagA family - - - - - - - - - - - - CarbopepD_reg_2,Plug,TonB_dep_Rec k59_113462_1 756067.MicvaDRAFT_2526 7.39e-17 79.7 COG0145@1|root,COG0146@1|root,COG0145@2|Bacteria,COG0146@2|Bacteria,1G02W@1117|Cyanobacteria,1H8RM@1150|Oscillatoriales 1117|Cyanobacteria EQ N-methylhydantoinase B acetone carboxylase alpha subunit oplaH - 3.5.2.9 ko:K01469 ko00480,map00480 - R00251 RC00553 ko00000,ko00001,ko01000 - - - Hydant_A_N,Hydantoinase_A,Hydantoinase_B k59_113462_2 944435.AXAJ01000012_gene2868 1.64e-20 93.2 COG0480@1|root,COG0480@2|Bacteria,1MUCV@1224|Proteobacteria,2VJD5@28216|Betaproteobacteria,1K214@119060|Burkholderiaceae 28216|Betaproteobacteria J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome fusA2 - - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2 k59_395851_1 158500.BV97_02692 1.78e-122 358.0 COG0454@1|root,COG0456@2|Bacteria,1PMA3@1224|Proteobacteria,2TUU2@28211|Alphaproteobacteria,2K0BS@204457|Sphingomonadales 204457|Sphingomonadales K acetyltransferase - - - - - - - - - - - - - k59_1525880_1 1386089.N865_08750 7.75e-17 80.9 COG0454@1|root,COG0456@2|Bacteria,2IHG4@201174|Actinobacteria,4FGF4@85021|Intrasporangiaceae 201174|Actinobacteria K N-acetyltransferase GCN5 - - - - - - - - - - - - Acetyltransf_1 k59_1638845_2 765912.Thimo_2538 9.45e-38 137.0 COG1420@1|root,COG1420@2|Bacteria,1MVX4@1224|Proteobacteria,1RR2F@1236|Gammaproteobacteria,1WXB7@135613|Chromatiales 135613|Chromatiales K Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons hrcA - - ko:K03705 - - - - ko00000,ko03000 - - - HrcA,HrcA_DNA-bdg k59_508908_1 1121101.HMPREF1532_03736 5.61e-18 87.4 COG4886@1|root,COG4886@2|Bacteria,4NPMD@976|Bacteroidetes,2FS2K@200643|Bacteroidia 976|Bacteroidetes S Leucine-rich repeat (LRR) protein - - - - - - - - - - - - - k59_791512_1 861299.J421_0476 1.83e-72 246.0 COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,1ZTK4@142182|Gemmatimonadetes 142182|Gemmatimonadetes KLT Tetratricopeptide repeat - - 2.7.11.1 ko:K08884,ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase,TPR_12 k59_565569_1 1144305.PMI02_00672 3.95e-63 202.0 COG3386@1|root,COG3386@2|Bacteria 2|Bacteria G gluconolactonase activity - - 3.1.1.17 ko:K01053 ko00030,ko00053,ko00930,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,map00030,map00053,map00930,map01100,map01110,map01120,map01130,map01200,map01220 M00129 R01519,R02933,R03751 RC00537,RC00983 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Esterase,SGL k59_283093_1 1123279.ATUS01000001_gene916 1.31e-31 121.0 COG3807@1|root,COG3807@2|Bacteria,1QWZW@1224|Proteobacteria,1T31J@1236|Gammaproteobacteria,1JC1Y@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S COG3103 SH3 domain protein ygiM - - ko:K07184 - - - - ko00000 - - - SH3_3 k59_792599_1 1216007.AOPM01000060_gene1770 5.57e-10 59.7 COG4968@1|root,COG4968@2|Bacteria,1N6QE@1224|Proteobacteria,1SCBS@1236|Gammaproteobacteria,2Q2IQ@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria NU COG4968 Tfp pilus assembly protein PilE pilE - - ko:K02655 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - ComP_DUS,N_methyl k59_858425_1 69395.JQLZ01000004_gene793 2.72e-43 160.0 COG4232@1|root,COG4233@1|root,COG4232@2|Bacteria,COG4233@2|Bacteria,1MU8W@1224|Proteobacteria,2TTUM@28211|Alphaproteobacteria,2KF2F@204458|Caulobacterales 204458|Caulobacterales CO cytochrome c biogenesis protein - - 1.8.1.8 ko:K04084 - - - - ko00000,ko01000,ko03110 5.A.1.1 - - DsbC,DsbD,Thioredoxin_7 k59_1705058_1 436308.Nmar_0560 1.78e-34 121.0 COG1225@1|root,arCOG00310@2157|Archaea,41SN5@651137|Thaumarchaeota 651137|Thaumarchaeota O AhpC/TSA antioxidant enzyme - - 1.11.1.15 ko:K03564 - - - - ko00000,ko01000 - - - AhpC-TSA k59_1705058_2 1229909.NSED_02835 1.57e-49 163.0 COG0580@1|root,arCOG04431@2157|Archaea,41S5R@651137|Thaumarchaeota 651137|Thaumarchaeota G Major Intrinsic Protein - - - ko:K06188,ko:K09866 ko04962,ko04976,map04962,map04976 - - - ko00000,ko00001,ko02000 1.A.8 - - MIP k59_1083740_1 1463854.JOHT01000007_gene3416 7.62e-31 130.0 COG0665@1|root,COG0665@2|Bacteria,2GPX6@201174|Actinobacteria 201174|Actinobacteria E FAD dependent oxidoreductase - - - - - - - - - - - - DAO k59_179803_1 1415778.JQMM01000001_gene1461 5.23e-146 436.0 COG0280@1|root,COG0281@1|root,COG0280@2|Bacteria,COG0281@2|Bacteria,1MU0A@1224|Proteobacteria,1RN5F@1236|Gammaproteobacteria,1J4Q5@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C malic enzyme maeB - 1.1.1.38,1.1.1.40 ko:K00027,ko:K00029 ko00620,ko00710,ko01100,ko01120,ko01200,ko02020,map00620,map00710,map01100,map01120,map01200,map02020 M00169,M00172 R00214,R00216 RC00105 ko00000,ko00001,ko00002,ko01000 - - - Malic_M,PTA_PTB,malic k59_1705065_1 626887.J057_10796 3.7e-85 265.0 COG0439@1|root,COG0439@2|Bacteria,1MU4H@1224|Proteobacteria,1T1GN@1236|Gammaproteobacteria 1236|Gammaproteobacteria EI Biotin carboxylase pycA - 6.4.1.1 ko:K01959 ko00020,ko00620,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00720,map01100,map01120,map01200,map01230 M00173,M00620 R00344 RC00040,RC00367 ko00000,ko00001,ko00002,ko01000 - - - Biotin_carb_C,Biotin_carb_N,CPSase_L_D2 k59_970257_1 998088.B565_3975 1.07e-67 224.0 COG0339@1|root,COG0339@2|Bacteria,1MU1K@1224|Proteobacteria,1RMAH@1236|Gammaproteobacteria,1Y3G7@135624|Aeromonadales 135624|Aeromonadales E Peptidase family M3 prlC - 3.4.24.70 ko:K01414 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M3 k59_970257_2 1395571.TMS3_0102570 1.9e-05 44.3 COG3529@1|root,COG3529@2|Bacteria,1NC40@1224|Proteobacteria,1SEJF@1236|Gammaproteobacteria 1236|Gammaproteobacteria S nucleic-acid-binding protein containing a Zn-ribbon domain - - - ko:K07070 - - - - ko00000 - - - DUF2387 k59_1591892_1 627192.SLG_25380 1.25e-32 127.0 COG0438@1|root,COG0438@2|Bacteria,1MVIM@1224|Proteobacteria,2TR88@28211|Alphaproteobacteria,2K0WY@204457|Sphingomonadales 204457|Sphingomonadales M Glycosyl transferase - - - - - - - - - - - - Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4 k59_462366_1 864069.MicloDRAFT_00003090 6.85e-08 52.0 COG2207@1|root,COG2207@2|Bacteria,1NHAP@1224|Proteobacteria 1224|Proteobacteria K helix_turn_helix, arabinose operon control protein - - - - - - - - - - - - HTH_18 k59_1366488_1 502025.Hoch_6864 1.62e-73 239.0 COG1164@1|root,COG1164@2|Bacteria,1MXAC@1224|Proteobacteria,42NAD@68525|delta/epsilon subdivisions,2WKEY@28221|Deltaproteobacteria,2Z1IJ@29|Myxococcales 28221|Deltaproteobacteria E PFAM peptidase M3A and M3B thimet oligopeptidase F pepF - - ko:K08602 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M3,Peptidase_M3_N k59_1028150_1 55529.EKX39174 1.29e-39 153.0 COG0642@1|root,KOG0519@2759|Eukaryota 2759|Eukaryota T phosphorelay sensor kinase activity - GO:0000155,GO:0000160,GO:0000166,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0004888,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008144,GO:0008150,GO:0008152,GO:0009653,GO:0009784,GO:0009897,GO:0009898,GO:0009986,GO:0009987,GO:0016020,GO:0016021,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0017076,GO:0018106,GO:0018193,GO:0018202,GO:0019199,GO:0019538,GO:0019932,GO:0019933,GO:0019935,GO:0023014,GO:0023052,GO:0030154,GO:0030435,GO:0030554,GO:0030587,GO:0031150,GO:0031154,GO:0031224,GO:0031226,GO:0031288,GO:0032502,GO:0032553,GO:0032555,GO:0032559,GO:0035556,GO:0035639,GO:0036094,GO:0036211,GO:0038023,GO:0043086,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043934,GO:0044092,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0046777,GO:0048646,GO:0048856,GO:0048869,GO:0050789,GO:0050790,GO:0050794,GO:0050896,GO:0051336,GO:0051342,GO:0051344,GO:0051346,GO:0051703,GO:0051704,GO:0051716,GO:0060089,GO:0065007,GO:0065009,GO:0071704,GO:0071944,GO:0090702,GO:0097159,GO:0097367,GO:0098552,GO:0098562,GO:0099120,GO:0140096,GO:1901265,GO:1901363,GO:1901564 - - - - - - - - - - CHASE,HATPase_c,HisKA,PAS,PAS_3,Response_reg k59_1366490_1 351348.Maqu_0927 1.06e-13 70.5 COG2518@1|root,COG2518@2|Bacteria,1MXQC@1224|Proteobacteria,1RMHZ@1236|Gammaproteobacteria,465SD@72275|Alteromonadaceae 1236|Gammaproteobacteria J Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins pcm GO:0003674,GO:0003824,GO:0004719,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006479,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0010340,GO:0016740,GO:0016741,GO:0019538,GO:0030091,GO:0032259,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0051998,GO:0071704,GO:0140096,GO:1901564 2.1.1.77 ko:K00573 - - - - ko00000,ko01000 - - - PCMT k59_1366490_2 436308.Nmar_0312 2.21e-61 197.0 COG0142@1|root,arCOG01726@2157|Archaea,41SEV@651137|Thaumarchaeota 651137|Thaumarchaeota H Belongs to the FPP GGPP synthase family - - 2.5.1.1,2.5.1.10,2.5.1.29 ko:K13787 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00364,M00365 R01658,R02003,R02061 RC00279 ko00000,ko00001,ko00002,ko01000,ko01006 - - - polyprenyl_synt k59_631717_1 1162668.LFE_1671 7.26e-95 294.0 COG2804@1|root,COG2804@2|Bacteria,3J0XR@40117|Nitrospirae 40117|Nitrospirae NU Type II/IV secretion system protein - - - ko:K02454,ko:K02652 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02035,ko02044 3.A.15,3.A.15.2 - - T2SSE,T2SSE_N k59_631718_1 882378.RBRH_03749 6.37e-43 155.0 COG2812@1|root,COG2812@2|Bacteria,1MVCK@1224|Proteobacteria,2VIE0@28216|Betaproteobacteria,1K1R7@119060|Burkholderiaceae 28216|Betaproteobacteria L DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity dnaX - 2.7.7.7 ko:K02343 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_delta2,DNA_pol3_gamma3,DNA_pol3_tau_5 k59_1422511_1 519989.ECTPHS_13073 3.22e-98 293.0 COG0090@1|root,COG0090@2|Bacteria,1MVTD@1224|Proteobacteria,1RMGR@1236|Gammaproteobacteria,1WWAW@135613|Chromatiales 135613|Chromatiales J One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity rplB - - ko:K02886 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L2,Ribosomal_L2_C k59_1253552_1 1121918.ARWE01000001_gene242 8.61e-91 295.0 COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1144@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1144@2|Bacteria,1MVM0@1224|Proteobacteria,42MZ0@68525|delta/epsilon subdivisions,2WJ96@28221|Deltaproteobacteria,43T1Q@69541|Desulfuromonadales 28221|Deltaproteobacteria C Domain of unknown function - - 1.2.7.1 ko:K03737 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00173,M00307 R01196,R10866 RC00004,RC02742 br01601,ko00000,ko00001,ko00002,ko01000 - - - EKR,PFOR_II,POR,POR_N,TPP_enzyme_C k59_236090_1 316067.Geob_3174 2.22e-06 50.4 COG0455@1|root,COG0455@2|Bacteria,1R8IW@1224|Proteobacteria,42R3H@68525|delta/epsilon subdivisions,2WMNY@28221|Deltaproteobacteria,43T10@69541|Desulfuromonadales 28221|Deltaproteobacteria D NUBPL iron-transfer P-loop NTPase - - - ko:K04562 - - - - ko00000,ko02035 - - - AAA_31,CbiA,HTH_25,ParA k59_914282_1 398767.Glov_2878 1.64e-41 150.0 COG1477@1|root,COG1477@2|Bacteria,1MW6K@1224|Proteobacteria,42MZQ@68525|delta/epsilon subdivisions,2WJNE@28221|Deltaproteobacteria,43S4W@69541|Desulfuromonadales 28221|Deltaproteobacteria M Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein apbE - 2.7.1.180 ko:K03734 - - - - ko00000,ko01000 - - - ApbE k59_1140171_1 314278.NB231_10969 5.71e-47 166.0 COG3852@1|root,COG3852@2|Bacteria,1MVN6@1224|Proteobacteria,1RN15@1236|Gammaproteobacteria,1WWFQ@135613|Chromatiales 135613|Chromatiales T signal transduction histidine kinase - - 2.7.13.3 ko:K07708 ko02020,map02020 M00497 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA,PAS,PAS_4 k59_236091_1 935948.KE386495_gene1490 4.06e-34 124.0 COG0024@1|root,COG0024@2|Bacteria,1TQC1@1239|Firmicutes,248I8@186801|Clostridia,42F6V@68295|Thermoanaerobacterales 186801|Clostridia J TIGRFAM methionine aminopeptidase, type I map - 3.4.11.18 ko:K01265 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M24 k59_236091_2 877424.ATWC01000002_gene2777 5.86e-28 102.0 COG0361@1|root,COG0361@2|Bacteria,1V9ZK@1239|Firmicutes,24MQE@186801|Clostridia,27NSG@186928|unclassified Lachnospiraceae 186801|Clostridia J One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex infA - - ko:K02518 - - - - ko00000,ko03012 - - - eIF-1a k59_688319_1 983544.Lacal_0061 8.33e-16 74.3 COG0664@1|root,COG0664@2|Bacteria,4NKW5@976|Bacteroidetes,1HYCG@117743|Flavobacteriia 976|Bacteroidetes K - catabolite gene activator and regulatory subunit of cAMP-dependent protein - - - ko:K10914 ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111 - - - ko00000,ko00001,ko03000 - - - HTH_Crp_2,cNMP_binding k59_1083794_1 566466.NOR53_2853 2.88e-48 161.0 COG3316@1|root,COG3316@2|Bacteria,1MWZ2@1224|Proteobacteria,1RRC2@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Transposase and inactivated derivatives - - - ko:K07498 - - - - ko00000 - - - DDE_Tnp_IS240 k59_1253595_1 1121937.AUHJ01000001_gene361 2.34e-43 148.0 COG1853@1|root,COG1853@2|Bacteria,1RGYM@1224|Proteobacteria,1S97V@1236|Gammaproteobacteria,468UV@72275|Alteromonadaceae 1236|Gammaproteobacteria S Flavin reductase like domain - - - - - - - - - - - - Flavin_Reduct k59_1083804_1 1144275.COCOR_03152 1.31e-35 137.0 COG3391@1|root,COG3391@2|Bacteria,1R66T@1224|Proteobacteria,439FZ@68525|delta/epsilon subdivisions,2X4RS@28221|Deltaproteobacteria,2YZGC@29|Myxococcales 28221|Deltaproteobacteria G 6-phosphogluconolactonase activity - - - - - - - - - - - - - k59_1083818_1 1500301.JQMF01000025_gene6093 4.66e-16 84.0 COG0515@1|root,COG2203@1|root,COG3899@1|root,COG4191@1|root,COG0515@2|Bacteria,COG2203@2|Bacteria,COG3899@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TQX3@28211|Alphaproteobacteria,4BI7H@82115|Rhizobiaceae 28211|Alphaproteobacteria T Protein tyrosine kinase - - - - - - - - - - - - AAA_16,GAF,GAF_2,HATPase_c,HisKA,Pkinase k59_1310062_1 1382305.AZUC01000043_gene207 2.31e-12 72.8 COG0591@1|root,COG0591@2|Bacteria,1TQCK@1239|Firmicutes,4HB5K@91061|Bacilli,26G88@186818|Planococcaceae 91061|Bacilli E Sodium:solute symporter family - - - ko:K03307 - - - - ko00000 2.A.21 - - SSF k59_236114_1 1122225.AULQ01000001_gene1577 2.07e-10 62.0 COG0454@1|root,COG0456@2|Bacteria,4NNG9@976|Bacteroidetes,1I23X@117743|Flavobacteriia 976|Bacteroidetes K acetyltransferase yjgM - - ko:K03828 - - - - ko00000,ko01000 - - - Acetyltransf_1 k59_970333_1 867845.KI911784_gene770 1.09e-130 401.0 COG1472@1|root,COG1472@2|Bacteria,2G639@200795|Chloroflexi,374XN@32061|Chloroflexia 32061|Chloroflexia G Belongs to the glycosyl hydrolase 3 family - - 3.2.1.21 ko:K05349 ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110 - R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040 RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248 ko00000,ko00001,ko01000 - GH3 - Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C,PA14 k59_236117_1 1131553.JIBI01000005_gene2227 7.57e-88 278.0 COG0568@1|root,COG0568@2|Bacteria,1MVNJ@1224|Proteobacteria,2VH74@28216|Betaproteobacteria,371SD@32003|Nitrosomonadales 28216|Betaproteobacteria K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth rpoD - - ko:K03086 - - - - ko00000,ko03021 - - - Sigma70_ner,Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4 k59_1648811_1 330214.NIDE4034 8.68e-68 206.0 COG0526@1|root,COG0526@2|Bacteria 2|Bacteria CO cell redox homeostasis bta - 1.8.1.8 ko:K03671,ko:K03672 ko04621,ko05418,map04621,map05418 - - - ko00000,ko00001,ko01000,ko03110 - - - Thioredoxin,TraF k59_1648813_1 948106.AWZT01000007_gene3593 4.46e-69 225.0 COG1190@1|root,COG1190@2|Bacteria,1MX1V@1224|Proteobacteria,2VH1A@28216|Betaproteobacteria,1K1TR@119060|Burkholderiaceae 28216|Betaproteobacteria J Belongs to the class-II aminoacyl-tRNA synthetase family lysS - 6.1.1.6 ko:K04567 ko00970,map00970 M00359,M00360 R03658 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_2,tRNA_anti-codon k59_801794_1 1415778.JQMM01000001_gene415 3.24e-83 261.0 COG0739@1|root,COG0739@2|Bacteria,1MVTF@1224|Proteobacteria,1RM7S@1236|Gammaproteobacteria,1J4JE@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M COG0739 Membrane proteins related to metalloendopeptidases yebA - - - - - - - - - - - OapA,OapA_N,Peptidase_M23 k59_1479935_1 316407.85676354 1.02e-141 405.0 COG0644@1|root,COG0644@2|Bacteria,1MXQY@1224|Proteobacteria,1RZ79@1236|Gammaproteobacteria,3XM79@561|Escherichia 1236|Gammaproteobacteria C bacteriocin immunity cbrA GO:0000166,GO:0003674,GO:0005488,GO:0008150,GO:0008152,GO:0009404,GO:0009987,GO:0019748,GO:0030153,GO:0036094,GO:0043167,GO:0043168,GO:0044237,GO:0048037,GO:0050660,GO:0050662,GO:0097159,GO:1901265,GO:1901363 1.3.1.111,1.3.1.83 ko:K10960 ko00860,ko00900,ko01100,ko01110,map00860,map00900,map01100,map01110 - R02063,R08754,R08755,R08756,R11226,R11518 RC00212,RC00522,RC01823 ko00000,ko00001,ko01000 - - - FAD_binding_3 k59_1196948_1 1122137.AQXF01000002_gene493 3.26e-49 166.0 COG1295@1|root,COG1295@2|Bacteria,1MXQA@1224|Proteobacteria,2TTN5@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Ribonuclease, BN rbn - - ko:K07058 - - - - ko00000 - - - Virul_fac_BrkB k59_1196948_2 1510531.JQJJ01000008_gene3708 3.3e-34 127.0 COG0484@1|root,COG0484@2|Bacteria,1MUZ4@1224|Proteobacteria,2TR01@28211|Alphaproteobacteria,3JU9R@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria O DnaJ C terminal domain cbpA - - - - - - - - - - - DnaJ,DnaJ_C k59_914354_1 1122137.AQXF01000005_gene1139 5.11e-108 325.0 COG0612@1|root,COG0612@2|Bacteria,1MVST@1224|Proteobacteria,2TR39@28211|Alphaproteobacteria 28211|Alphaproteobacteria C Belongs to the peptidase M16 family mpp - - - - - - - - - - - Peptidase_M16,Peptidase_M16_C k59_123700_1 702113.PP1Y_AT27853 6.55e-113 337.0 COG0056@1|root,COG0056@2|Bacteria,1MUG7@1224|Proteobacteria,2TQYK@28211|Alphaproteobacteria,2K08A@204457|Sphingomonadales 204457|Sphingomonadales C Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit atpA - 3.6.3.14 ko:K02111 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - - ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N k59_1705136_1 1121937.AUHJ01000022_gene1376 1.45e-108 324.0 COG3525@1|root,COG3525@2|Bacteria,1QR2G@1224|Proteobacteria,1RZNM@1236|Gammaproteobacteria,466IG@72275|Alteromonadaceae 1236|Gammaproteobacteria G beta-N-acetylglucosaminidase - - 3.2.1.35 ko:K01197 ko00531,ko01100,map00531,map01100 M00076,M00077 R07824,R07825,R10905 - ko00000,ko00001,ko00002,ko00536,ko00537,ko01000,ko02042 - - - Glyco_hydro_20b,NAGidase k59_1310118_1 1535422.ND16A_0740 1.32e-28 113.0 COG3119@1|root,COG3119@2|Bacteria,1MUJH@1224|Proteobacteria,1RN2V@1236|Gammaproteobacteria,2Q7EB@267889|Colwelliaceae 1236|Gammaproteobacteria P PFAM sulfatase - - 3.1.6.1 ko:K01130 ko00140,ko00600,map00140,map00600 - R03980,R04856 RC00128,RC00231 ko00000,ko00001,ko01000 - - - Sulfatase k59_1310118_2 985054.JQEZ01000004_gene806 2.33e-59 199.0 28HMZ@1|root,2Z7WD@2|Bacteria,1MU3Q@1224|Proteobacteria,2TSGX@28211|Alphaproteobacteria,4ND0W@97050|Ruegeria 28211|Alphaproteobacteria S Protein of unknown function (DUF3604) - - - - - - - - - - - - DUF3604 k59_123706_1 666685.R2APBS1_3172 1.26e-81 265.0 COG0612@1|root,COG0612@2|Bacteria,1MVST@1224|Proteobacteria,1RTWB@1236|Gammaproteobacteria,1X4M8@135614|Xanthomonadales 135614|Xanthomonadales S Insulinase (Peptidase family M16) - - - ko:K07263 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M16,Peptidase_M16_C k59_1196974_1 1131553.JIBI01000037_gene2075 8.52e-31 112.0 COG1714@1|root,COG1714@2|Bacteria,1REEC@1224|Proteobacteria,2VRE0@28216|Betaproteobacteria,3738E@32003|Nitrosomonadales 28216|Betaproteobacteria S RDD family - - - - - - - - - - - - RDD k59_1196974_2 1095769.CAHF01000011_gene2663 6.63e-31 119.0 COG0795@1|root,COG0795@2|Bacteria,1MVW3@1224|Proteobacteria,2VHA1@28216|Betaproteobacteria,472IT@75682|Oxalobacteraceae 28216|Betaproteobacteria S Predicted permease YjgP/YjgQ family lptG - - ko:K11720 ko02010,map02010 M00320 - - ko00000,ko00001,ko00002,ko02000 1.B.42.1 - - YjgP_YjgQ k59_1253635_1 1122599.AUGR01000006_gene3894 2e-17 77.4 COG0239@1|root,COG0239@2|Bacteria,1MZNH@1224|Proteobacteria,1S8RQ@1236|Gammaproteobacteria,1XKZ9@135619|Oceanospirillales 135619|Oceanospirillales D Important for reducing fluoride concentration in the cell, thus reducing its toxicity crcB - - ko:K06199 - - - - ko00000,ko02000 1.A.43.1,1.A.43.2,1.A.43.3 - - CRCB k59_1253635_2 314287.GB2207_01707 3.3e-37 139.0 COG0172@1|root,COG0172@2|Bacteria,1MUJF@1224|Proteobacteria,1RNAQ@1236|Gammaproteobacteria,1J4R1@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) serS GO:0000287,GO:0003674,GO:0003824,GO:0004812,GO:0004828,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006434,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009059,GO:0009069,GO:0009070,GO:0009987,GO:0010467,GO:0016053,GO:0016070,GO:0016259,GO:0016260,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0042802,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046872,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 6.1.1.11 ko:K01875 ko00970,map00970 M00359,M00360 R03662,R08218 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iSDY_1059.SDY_2368 Seryl_tRNA_N,tRNA-synt_2b k59_1648860_1 1415778.JQMM01000001_gene335 4.99e-110 328.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,1J4KR@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains prsR - - ko:K02481 - - - - ko00000,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_123710_1 1121918.ARWE01000001_gene3534 2.57e-52 187.0 COG5009@1|root,COG5009@2|Bacteria,1MU5A@1224|Proteobacteria,42MJB@68525|delta/epsilon subdivisions,2WIXF@28221|Deltaproteobacteria,43S7U@69541|Desulfuromonadales 28221|Deltaproteobacteria M Transglycosylase mrcA - 2.4.1.129,3.4.16.4 ko:K05366 ko00550,ko01100,ko01501,map00550,map01100,map01501 - - - ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 iAF987.Gmet_0354 PCB_OB,Transgly,Transpeptidase k59_10772_1 267747.PPA1669 5.41e-41 152.0 COG1073@1|root,COG1073@2|Bacteria,2IA0Y@201174|Actinobacteria 201174|Actinobacteria S alpha beta - - - - - - - - - - - - Abhydrolase_6,Hydrolase_4,Peptidase_S15,Peptidase_S9 k59_575259_1 1249627.D779_1318 3.14e-71 232.0 COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,1RMWA@1236|Gammaproteobacteria,1WWMG@135613|Chromatiales 135613|Chromatiales L DEAD-box RNA helicase involved in RNA degradation. Has RNA-dependent ATPase activity and unwinds double-stranded RNA rhlB - 3.6.4.13 ko:K03732 ko03018,map03018 M00394 - - ko00000,ko00001,ko00002,ko01000,ko03019 - - - DEAD,Helicase_C k59_801815_1 436308.Nmar_1425 1.94e-120 347.0 arCOG08771@1|root,arCOG08771@2157|Archaea,41SNZ@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_801815_2 436308.Nmar_1426 8.71e-52 164.0 COG3432@1|root,arCOG01055@2157|Archaea,41SUJ@651137|Thaumarchaeota 651137|Thaumarchaeota K Winged helix-turn-helix - - - - - - - - - - - - HTH_45 k59_801815_3 700598.Niako_6516 3.65e-11 62.4 COG0009@1|root,COG0009@2|Bacteria,4NDZR@976|Bacteroidetes,1IQWM@117747|Sphingobacteriia 976|Bacteroidetes J Belongs to the SUA5 family yciO - - - - - - - - - - - Sua5_yciO_yrdC k59_1253640_1 1266925.JHVX01000004_gene1236 1.26e-55 187.0 COG0477@1|root,COG2814@2|Bacteria,1NE49@1224|Proteobacteria,2VNGV@28216|Betaproteobacteria,3742G@32003|Nitrosomonadales 28216|Betaproteobacteria EGP Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 k59_1028253_1 997884.HMPREF1068_02869 1.42e-31 128.0 COG0178@1|root,COG0178@2|Bacteria,4NFQU@976|Bacteroidetes,2FNMG@200643|Bacteroidia,4AN5R@815|Bacteroidaceae 976|Bacteroidetes L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate uvrA2 - - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - ABC_tran k59_744849_1 1123368.AUIS01000018_gene729 3e-66 217.0 COG0477@1|root,COG2814@2|Bacteria,1MU1I@1224|Proteobacteria,1RNTG@1236|Gammaproteobacteria,2NC1Z@225057|Acidithiobacillales 225057|Acidithiobacillales P major facilitator superfamily - - - ko:K03446 - M00701 - - ko00000,ko00002,ko02000 2.A.1.3 - - MFS_1 k59_236167_1 1123073.KB899241_gene3057 1.93e-103 311.0 COG2115@1|root,COG2115@2|Bacteria,1MXS2@1224|Proteobacteria,1RN5Y@1236|Gammaproteobacteria,1X4B9@135614|Xanthomonadales 135614|Xanthomonadales G Belongs to the xylose isomerase family xylA GO:0003674,GO:0003824,GO:0005975,GO:0005996,GO:0008150,GO:0008152,GO:0009045,GO:0009056,GO:0016052,GO:0016853,GO:0016860,GO:0016861,GO:0019321,GO:0019323,GO:0042732,GO:0042843,GO:0044238,GO:0044281,GO:0044282,GO:0046365,GO:0071704,GO:1901575 5.3.1.5 ko:K01805 ko00040,ko00051,ko01100,map00040,map00051,map01100 - R00878,R01432 RC00376,RC00516 ko00000,ko00001,ko01000 - - - - k59_689522_1 1068980.ARVW01000001_gene2860 2.04e-70 230.0 COG0318@1|root,COG0318@2|Bacteria,2GKDF@201174|Actinobacteria,4DYWP@85010|Pseudonocardiales 201174|Actinobacteria IQ Acyl-CoA synthetase (AMP-forming) AMP-acid ligase II - - - ko:K00666 - - - - ko00000,ko01000,ko01004 - - - AMP-binding,AMP-binding_C,Polyketide_cyc2 k59_463607_1 1187848.AJYQ01000008_gene535 1.14e-90 279.0 COG2355@1|root,COG2355@2|Bacteria,1MWEW@1224|Proteobacteria,1RQ31@1236|Gammaproteobacteria,1XV2J@135623|Vibrionales 135623|Vibrionales E COG2355 Zn-dependent dipeptidase, microsomal dipeptidase homolog - - 3.4.13.19 ko:K01273 - - - - ko00000,ko00537,ko01000,ko01002,ko04147 - - - Peptidase_M19 k59_633058_1 1500257.JQNM01000006_gene2115 1.34e-64 216.0 COG0457@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2TRUI@28211|Alphaproteobacteria,4B9BA@82115|Rhizobiaceae 28211|Alphaproteobacteria T Adenylate cyclase - - - - - - - - - - - - Guanylate_cyc,TPR_16,TPR_19,TPR_8,Trans_reg_C k59_803110_1 1254432.SCE1572_14660 4.27e-57 191.0 COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,42NF6@68525|delta/epsilon subdivisions,2WKVH@28221|Deltaproteobacteria 28221|Deltaproteobacteria V ABC transporter - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_803110_2 935948.KE386495_gene1732 7.04e-24 103.0 COG1277@1|root,COG1277@2|Bacteria,1UZXS@1239|Firmicutes,248ME@186801|Clostridia,42FRK@68295|Thermoanaerobacterales 186801|Clostridia S PFAM ABC-2 type transporter - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane,ABC2_membrane_2,ABC2_membrane_3,ABC2_membrane_5 k59_68972_1 383381.EH30_14350 7.91e-81 260.0 COG3104@1|root,COG3104@2|Bacteria,1MW6W@1224|Proteobacteria,2U15C@28211|Alphaproteobacteria,2K05X@204457|Sphingomonadales 204457|Sphingomonadales E amino acid peptide transporter - - - ko:K03305 - - - - ko00000 2.A.17 - - PTR2 k59_181327_1 436308.Nmar_0977 1.5e-105 318.0 COG0702@1|root,arCOG03015@2157|Archaea 2157|Archaea GM NAD-dependent epimerase dehydratase - - 4.2.1.46 ko:K01710 ko00521,ko00523,ko00525,ko01055,ko01130,map00521,map00523,map00525,map01055,map01130 M00793 R06513 RC00402 ko00000,ko00001,ko00002,ko01000 - - - NAD_binding_10 k59_971459_1 1502852.FG94_00974 1.06e-29 117.0 COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,2VHGH@28216|Betaproteobacteria,472MA@75682|Oxalobacteraceae 28216|Betaproteobacteria S ABC transporter yheS - - ko:K06158 - - - - ko00000,ko03012 - - - ABC_tran,ABC_tran_CTD,ABC_tran_Xtn k59_1650208_1 504474.cu0999 9.83e-77 254.0 COG0021@1|root,COG0021@2|Bacteria,2GJ1K@201174|Actinobacteria,22JPY@1653|Corynebacteriaceae 201174|Actinobacteria G Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate tkt - 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 - - - Transket_pyr,Transketolase_C,Transketolase_N k59_407257_2 641112.ACOK01000088_gene1313 1.88e-37 140.0 COG2262@1|root,COG2262@2|Bacteria,1TNZB@1239|Firmicutes,248IU@186801|Clostridia,3WH00@541000|Ruminococcaceae 186801|Clostridia S GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis hflX - - ko:K03665 - - - - ko00000,ko03009 - - - GTP-bdg_M,GTP-bdg_N,MMR_HSR1 k59_803124_1 203122.Sde_1609 1.63e-98 297.0 COG1219@1|root,COG1219@2|Bacteria,1MVQK@1224|Proteobacteria,1RN9N@1236|Gammaproteobacteria,464XT@72275|Alteromonadaceae 1236|Gammaproteobacteria O ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP clpX GO:0000166,GO:0000502,GO:0002020,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009376,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0019899,GO:0019904,GO:0030163,GO:0030164,GO:0030554,GO:0031597,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0035639,GO:0036094,GO:0042623,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0043335,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0051301,GO:0051704,GO:0070011,GO:0071704,GO:0097159,GO:0097367,GO:0097718,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1904949,GO:1905368,GO:1905369 - ko:K03544 ko04112,map04112 - - - ko00000,ko00001,ko03110 - - - AAA_2,ClpB_D2-small,zf-C4_ClpX k59_689540_1 452662.SJA_C1-02590 1.45e-58 196.0 COG4221@1|root,COG4221@2|Bacteria,1MVYG@1224|Proteobacteria,2TWIJ@28211|Alphaproteobacteria,2KCNT@204457|Sphingomonadales 204457|Sphingomonadales S Belongs to the short-chain dehydrogenases reductases (SDR) family - - - - - - - - - - - - adh_short k59_576654_1 1499683.CCFF01000016_gene605 6.96e-20 95.9 COG0544@1|root,COG0544@2|Bacteria,1TQQ8@1239|Firmicutes,248C3@186801|Clostridia,36DYI@31979|Clostridiaceae 186801|Clostridia D Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase tig GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - ko:K03545 - - - - ko00000 - - - FKBP_C,Trigger_C,Trigger_N k59_633081_1 1144307.PMI04_01242 4.15e-74 234.0 COG2124@1|root,COG2124@2|Bacteria,1MY5H@1224|Proteobacteria,2TR6X@28211|Alphaproteobacteria,2K2P8@204457|Sphingomonadales 204457|Sphingomonadales Q Cytochrome P450 - - - - - - - - - - - - p450 k59_1593580_1 1469245.JFBG01000051_gene2137 3.97e-10 63.2 COG0144@1|root,COG0144@2|Bacteria,1MWPE@1224|Proteobacteria,1RN8X@1236|Gammaproteobacteria,1WVWG@135613|Chromatiales 135613|Chromatiales J Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA - - 2.1.1.176 ko:K03500 - - - - ko00000,ko01000,ko03009 - - - Methyltr_RsmB-F,Methyltr_RsmF_N,NusB k59_1593580_2 358681.BBR47_37290 4.97e-09 58.5 COG0223@1|root,COG0223@2|Bacteria,1TQ32@1239|Firmicutes,4HART@91061|Bacilli,26RTF@186822|Paenibacillaceae 91061|Bacilli J Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus fmt GO:0003674,GO:0003824,GO:0004479,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006413,GO:0006464,GO:0006518,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016741,GO:0016742,GO:0019538,GO:0019988,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036211,GO:0043043,GO:0043170,GO:0043412,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0046483,GO:0071704,GO:0071951,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 2.1.2.9 ko:K00604 ko00670,ko00970,map00670,map00970 - R03940 RC00026,RC00165 ko00000,ko00001,ko01000 - - iSB619.SA_RS06010 Formyl_trans_C,Formyl_trans_N k59_915485_1 56110.Oscil6304_2446 6.69e-29 126.0 COG0515@1|root,COG0642@1|root,COG0784@1|root,COG3899@1|root,COG0515@2|Bacteria,COG0784@2|Bacteria,COG2205@2|Bacteria,COG3899@2|Bacteria,1GBKM@1117|Cyanobacteria,1H7D9@1150|Oscillatoriales 1117|Cyanobacteria KLT Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - AAA_16,GAF,GAF_2,HATPase_c,HisKA,Pkinase,Response_reg k59_915485_2 251229.Chro_0066 9.26e-07 51.2 COG0642@1|root,COG2203@1|root,COG2203@2|Bacteria,COG2205@2|Bacteria,1FZZD@1117|Cyanobacteria,3VJ28@52604|Pleurocapsales 1117|Cyanobacteria T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - GAF,GAF_3,HATPase_c,HisKA k59_1254718_1 1317122.ATO12_18130 2.35e-15 84.3 COG3011@1|root,COG3011@2|Bacteria,4P1RW@976|Bacteroidetes,1I83X@117743|Flavobacteriia,2YK8R@290174|Aquimarina 976|Bacteroidetes S Protein conserved in bacteria - - - - - - - - - - - - DUF393,VKG_Carbox k59_407281_1 1144305.PMI02_03411 3.23e-82 265.0 COG4774@1|root,COG4774@2|Bacteria,1QURD@1224|Proteobacteria,2TWX2@28211|Alphaproteobacteria,2K975@204457|Sphingomonadales 204457|Sphingomonadales P TonB dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_294872_1 158500.BV97_01516 2.26e-187 541.0 COG0188@1|root,COG0188@2|Bacteria,1MURI@1224|Proteobacteria,2TQRQ@28211|Alphaproteobacteria,2K0IA@204457|Sphingomonadales 204457|Sphingomonadales L Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule parC - - ko:K02621 - - - - ko00000,ko01000,ko02048,ko03032,ko03036 - - - DNA_gyraseA_C,DNA_topoisoIV k59_190975_1 1122137.AQXF01000001_gene3232 5.02e-109 323.0 COG0189@1|root,COG0189@2|Bacteria,1MVUA@1224|Proteobacteria,2TQNE@28211|Alphaproteobacteria 28211|Alphaproteobacteria H Belongs to the prokaryotic GSH synthase family gshB GO:0003674,GO:0003824,GO:0004363,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006518,GO:0006575,GO:0006749,GO:0006750,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0019184,GO:0034641,GO:0042398,GO:0043043,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044424,GO:0044464,GO:0051186,GO:0051188,GO:0071704,GO:1901564,GO:1901566,GO:1901576 6.3.2.3 ko:K01920 ko00270,ko00480,ko01100,map00270,map00480,map01100 M00118 R00497,R10994 RC00096,RC00141 ko00000,ko00001,ko00002,ko01000 - - - GSH-S_ATP,GSH-S_N k59_1716323_1 379066.GAU_1887 6.93e-51 168.0 COG0669@1|root,COG0669@2|Bacteria,1ZTTQ@142182|Gemmatimonadetes 142182|Gemmatimonadetes H Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate coaD - 2.7.7.3 ko:K00954 ko00770,ko01100,map00770,map01100 M00120 R03035 RC00002 ko00000,ko00001,ko00002,ko01000 - - - CTP_transf_like k59_1716323_2 203119.Cthe_1277 8.94e-16 79.0 COG0742@1|root,COG0742@2|Bacteria,1V3JF@1239|Firmicutes,24JHR@186801|Clostridia,3WJC4@541000|Ruminococcaceae 186801|Clostridia L RNA methyltransferase, RsmD family rsmD - 2.1.1.171 ko:K08316 - - R07234 RC00003 ko00000,ko01000,ko03009 - - - Cons_hypoth95 k59_134672_1 1229909.NSED_03295 1.47e-20 85.5 arCOG08653@1|root,arCOG08653@2157|Archaea,41T9H@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_134672_2 1229909.NSED_05625 6.5e-114 336.0 COG0614@1|root,arCOG04233@2157|Archaea,41SXD@651137|Thaumarchaeota 651137|Thaumarchaeota P Periplasmic binding protein - - - ko:K02016 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko02000 3.A.1.14 - - Peripla_BP_2 k59_1207956_1 396014.BF93_10005 4.78e-48 165.0 COG0384@1|root,COG0384@2|Bacteria,2GM1W@201174|Actinobacteria 201174|Actinobacteria J Phenazine biosynthesis protein PhzF - - - - - - - - - - - - PhzC-PhzF k59_924981_1 1042375.AFPL01000046_gene1815 1.44e-287 819.0 COG2307@1|root,COG2308@1|root,COG2307@2|Bacteria,COG2308@2|Bacteria,1MX5P@1224|Proteobacteria,1RPDC@1236|Gammaproteobacteria,465B2@72275|Alteromonadaceae 1236|Gammaproteobacteria S Circularly permuted ATP-grasp type 2 - - - - - - - - - - - - Alpha-E,CP_ATPgrasp_2 k59_190980_1 349521.HCH_01808 8.57e-30 114.0 COG1694@1|root,COG3956@2|Bacteria,1MVKM@1224|Proteobacteria,1RNVU@1236|Gammaproteobacteria,1XI3P@135619|Oceanospirillales 135619|Oceanospirillales S pyrophosphohydrolase mazG - 3.6.1.9 ko:K04765 ko00230,ko00240,ko00760,ko00770,ko01100,map00230,map00240,map00760,map00770,map01100 - R00086,R00087,R00103,R00287,R00426,R00515,R00662,R00720,R03004,R03036,R11323 RC00002 ko00000,ko00001,ko01000 - - - MazG k59_190980_2 498211.CJA_2575 3.16e-45 162.0 COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,1RN3H@1236|Gammaproteobacteria,1FG0M@10|Cellvibrio 1236|Gammaproteobacteria KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance relA GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008728,GO:0008893,GO:0009116,GO:0009117,GO:0009119,GO:0009150,GO:0009259,GO:0009605,GO:0009987,GO:0009991,GO:0015949,GO:0015969,GO:0016020,GO:0016740,GO:0016772,GO:0016778,GO:0016787,GO:0016788,GO:0016794,GO:0019637,GO:0019693,GO:0030312,GO:0031667,GO:0033865,GO:0033875,GO:0034032,GO:0034035,GO:0034641,GO:0042278,GO:0042578,GO:0042594,GO:0044237,GO:0044238,GO:0044281,GO:0044464,GO:0046128,GO:0046483,GO:0050896,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:1901068,GO:1901135,GO:1901360,GO:1901564,GO:1901657 2.7.6.5 ko:K00951 ko00230,map00230 - R00429 RC00002,RC00078 ko00000,ko00001,ko01000 - - iSFV_1184.SFV_2673 ACT_4,HD_4,RelA_SpoT,TGS k59_1207957_1 1123366.TH3_14759 2.31e-106 333.0 COG2114@1|root,COG4252@1|root,COG2114@2|Bacteria,COG4252@2|Bacteria,1MV1V@1224|Proteobacteria,2TRTY@28211|Alphaproteobacteria,2JQU2@204441|Rhodospirillales 204441|Rhodospirillales T CHASE2 - - 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 - - - CHASE2,Guanylate_cyc k59_869913_1 177437.HRM2_19330 4.48e-46 155.0 COG1432@1|root,COG1432@2|Bacteria,1REF0@1224|Proteobacteria,42RN2@68525|delta/epsilon subdivisions,2WNV8@28221|Deltaproteobacteria 28221|Deltaproteobacteria V HNH endonuclease - - - - - - - - - - - - - k59_1547399_1 1121861.KB899912_gene974 5.51e-40 143.0 COG0765@1|root,COG0765@2|Bacteria,1MV3I@1224|Proteobacteria,2TR9C@28211|Alphaproteobacteria,2JPI5@204441|Rhodospirillales 204441|Rhodospirillales E COG0765 ABC-type amino acid transport system, permease component - - - ko:K09971 ko02010,map02010 M00232 - - ko00000,ko00001,ko00002,ko02000 3.A.1.3.18,3.A.1.3.7,3.A.1.3.8 - - BPD_transp_1 k59_1547399_2 472175.EL18_01512 2.76e-42 145.0 COG1126@1|root,COG1126@2|Bacteria,1MU9Q@1224|Proteobacteria,2TQX2@28211|Alphaproteobacteria,43IT0@69277|Phyllobacteriaceae 28211|Alphaproteobacteria E ABC-type polar amino acid transport system ATPase component glnQ - 3.6.3.21 ko:K02028,ko:K09972 ko02010,map02010 M00232,M00236 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.3,3.A.1.3.17,3.A.1.3.18,3.A.1.3.7,3.A.1.3.8 - - ABC_tran k59_869917_1 1122137.AQXF01000001_gene2693 6.33e-54 173.0 2EGX5@1|root,33APA@2|Bacteria,1NHMF@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - GGACT k59_304758_1 439292.Bsel_1731 7.58e-36 130.0 COG0074@1|root,COG0074@2|Bacteria,1TPIT@1239|Firmicutes,4HA2J@91061|Bacilli,26NA5@186821|Sporolactobacillaceae 91061|Bacilli C Succinyl-CoA ligase like flavodoxin domain sucD - 6.2.1.5 ko:K01902 ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374,M00620 R00405,R02404 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000 - - - CoA_binding,Ligase_CoA k59_304758_2 398767.Glov_3606 1.01e-27 109.0 COG0524@1|root,COG0524@2|Bacteria,1Q8Y3@1224|Proteobacteria,42NSV@68525|delta/epsilon subdivisions,2WJWD@28221|Deltaproteobacteria 28221|Deltaproteobacteria G PFAM PfkB domain protein - - - - - - - - - - - iAF987.Gmet_2683 PfkB k59_1433063_1 436308.Nmar_1529 1.1e-143 411.0 COG0731@1|root,arCOG04174@2157|Archaea,41SBS@651137|Thaumarchaeota 651137|Thaumarchaeota C Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe) taw1 - 4.1.3.44 ko:K15449 - - - - ko00000,ko01000,ko03016 - - - Radical_SAM,Wyosine_form k59_869925_1 883081.HMPREF9698_00048 3.94e-39 141.0 COG0237@1|root,COG0237@2|Bacteria,1V6FS@1239|Firmicutes,4HII3@91061|Bacilli,27GGT@186828|Carnobacteriaceae 91061|Bacilli H Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A coaE GO:0003674,GO:0003824,GO:0004140,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.1.24 ko:K00859 ko00770,ko01100,map00770,map01100 M00120 R00130 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - iSB619.SA_RS08510 CoaE k59_869935_1 525309.HMPREF0494_1821 1.11e-15 73.9 COG0228@1|root,COG0228@2|Bacteria,1VA0X@1239|Firmicutes,4HKNN@91061|Bacilli,3F6VV@33958|Lactobacillaceae 91061|Bacilli J Belongs to the bacterial ribosomal protein bS16 family rpsP GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02959 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011,ko03029 - - - Ribosomal_S16 k59_869935_2 391625.PPSIR1_33923 4.33e-14 68.2 COG1837@1|root,COG1837@2|Bacteria,1N7IX@1224|Proteobacteria,42TXI@68525|delta/epsilon subdivisions,2WQBS@28221|Deltaproteobacteria,2YW73@29|Myxococcales 28221|Deltaproteobacteria S Belongs to the UPF0109 family - - - ko:K06960 - - - - ko00000 - - - KH_4 k59_642401_1 316407.1799976 4.19e-128 372.0 COG1017@1|root,COG1018@1|root,COG1017@2|Bacteria,COG1018@2|Bacteria,1MV41@1224|Proteobacteria,1RMPJ@1236|Gammaproteobacteria,3XPAT@561|Escherichia 1236|Gammaproteobacteria C Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress hmp GO:0000166,GO:0001505,GO:0003674,GO:0003824,GO:0004155,GO:0005488,GO:0005504,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006807,GO:0006873,GO:0006875,GO:0006879,GO:0006950,GO:0008150,GO:0008152,GO:0008289,GO:0008941,GO:0009056,GO:0009987,GO:0016491,GO:0016645,GO:0016646,GO:0016667,GO:0016671,GO:0016705,GO:0016708,GO:0017144,GO:0019725,GO:0020037,GO:0030003,GO:0031406,GO:0032843,GO:0033293,GO:0033554,GO:0034641,GO:0036094,GO:0042133,GO:0042135,GO:0042592,GO:0042737,GO:0043167,GO:0043168,GO:0043177,GO:0044237,GO:0044248,GO:0044270,GO:0044424,GO:0044464,GO:0046209,GO:0046210,GO:0046906,GO:0046916,GO:0048037,GO:0048878,GO:0050660,GO:0050662,GO:0050801,GO:0050896,GO:0051213,GO:0051409,GO:0051716,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0055114,GO:0065007,GO:0065008,GO:0071500,GO:0071949,GO:0072593,GO:0097159,GO:0098771,GO:1901265,GO:1901363,GO:2001057 1.14.12.17 ko:K05916 ko05132,map05132 - - - ko00000,ko00001,ko01000 - - iECP_1309.ECP_2554 FAD_binding_6,Globin,NAD_binding_1 k59_925004_2 1123322.KB904735_gene1570 8.12e-28 109.0 COG3185@1|root,COG3185@2|Bacteria,2ID0M@201174|Actinobacteria 201174|Actinobacteria E Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - - - - - - - - - - Glyoxalase k59_304794_1 323097.Nham_3895 1.38e-87 268.0 COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,1MW7X@1224|Proteobacteria,2TTH8@28211|Alphaproteobacteria,3JWD8@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria L DDE superfamily endonuclease - - - - - - - - - - - - DDE_3,HTH_23,HTH_29,HTH_32 k59_416789_1 208439.AJAP_06205 4.4e-29 114.0 COG1280@1|root,COG1280@2|Bacteria,2IG0G@201174|Actinobacteria,4E2V2@85010|Pseudonocardiales 201174|Actinobacteria E LysE type translocator - - - - - - - - - - - - LysE k59_925009_1 522306.CAP2UW1_3923 1.59e-110 325.0 COG4105@1|root,COG4105@2|Bacteria,1MVS5@1224|Proteobacteria,2VH6I@28216|Betaproteobacteria,1KQ3X@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria M Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane bamD - - ko:K05807 - - - - ko00000,ko02000 1.B.33.1 - - YfiO k59_134737_1 1123247.AUIJ01000002_gene2326 1.56e-106 320.0 COG0439@1|root,COG0439@2|Bacteria,1MU4H@1224|Proteobacteria,2U25Z@28211|Alphaproteobacteria 28211|Alphaproteobacteria I An AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism accC GO:0003674,GO:0003824,GO:0004075,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0016053,GO:0016874,GO:0016879,GO:0019216,GO:0019217,GO:0019222,GO:0019752,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032787,GO:0042304,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046394,GO:0046890,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051055,GO:0062012,GO:0062014,GO:0065007,GO:0071704,GO:0072330,GO:0080090,GO:1901576 6.3.4.14,6.4.1.2 ko:K01961 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04385 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 - - - Biotin_carb_C,Biotin_carb_N,CPSase_L_D2 k59_1039715_2 1229909.NSED_07430 1.75e-42 149.0 arCOG08764@1|root,arCOG08764@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_1094346_1 1127673.GLIP_3499 1.99e-22 97.8 2C3X5@1|root,32RCX@2|Bacteria,1RKW4@1224|Proteobacteria,1S73W@1236|Gammaproteobacteria,467FK@72275|Alteromonadaceae 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_134738_1 247634.GPB2148_686 7.97e-87 275.0 COG0021@1|root,COG0021@2|Bacteria,1MUEY@1224|Proteobacteria,1RMWP@1236|Gammaproteobacteria,1J4RR@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria G Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate tkt - 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 - - - Transket_pyr,Transketolase_C,Transketolase_N k59_1716401_1 46429.BV95_03086 5.71e-59 191.0 COG1024@1|root,COG1024@2|Bacteria,1MVPQ@1224|Proteobacteria,2TTJ4@28211|Alphaproteobacteria,2K20K@204457|Sphingomonadales 204457|Sphingomonadales I enoyl-CoA hydratase - - - - - - - - - - - - ECH_1 k59_925021_1 365044.Pnap_0441 1.52e-14 78.6 COG0583@1|root,COG0583@2|Bacteria,1MX2A@1224|Proteobacteria,2VZBD@28216|Betaproteobacteria,4AGH8@80864|Comamonadaceae 28216|Betaproteobacteria K LysR substrate binding domain - - - - - - - - - - - - HTH_1,LysR_substrate k59_869974_1 1232410.KI421426_gene1485 7.02e-49 169.0 COG0282@1|root,COG0282@2|Bacteria,1MW61@1224|Proteobacteria,42MJA@68525|delta/epsilon subdivisions,2WJBJ@28221|Deltaproteobacteria,43T2K@69541|Desulfuromonadales 28221|Deltaproteobacteria F Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction ackA - 2.7.2.1 ko:K00925 ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200 M00357,M00579 R00315,R01353 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - Acetate_kinase k59_1660149_1 243231.GSU0306 1.4e-53 193.0 COG0068@1|root,COG0068@2|Bacteria,1MVP8@1224|Proteobacteria,42M3G@68525|delta/epsilon subdivisions,2WJ51@28221|Deltaproteobacteria,43S2B@69541|Desulfuromonadales 28221|Deltaproteobacteria O Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide hypF - - ko:K04656 - - - - ko00000 - - iAF987.Gmet_0119 Acylphosphatase,Sua5_yciO_yrdC,zf-HYPF k59_1717619_2 565045.NOR51B_2106 2.07e-50 172.0 COG0075@1|root,COG0075@2|Bacteria,1MWHJ@1224|Proteobacteria,1RMNR@1236|Gammaproteobacteria 1236|Gammaproteobacteria E Serine-pyruvate aminotransferase archaeal aspartate aminotransferase pucG - 2.6.1.44,2.6.1.45,2.6.1.51 ko:K00830 ko00250,ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko04146,map00250,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200,map04146 M00346,M00532 R00369,R00372,R00585,R00588 RC00006,RC00008,RC00018 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_5 k59_1040888_1 1229909.NSED_03530 5.59e-22 90.1 arCOG08684@1|root,arCOG08684@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_981352_1 1123355.JHYO01000005_gene871 1.83e-25 100.0 COG0745@1|root,COG0745@2|Bacteria,1MZAS@1224|Proteobacteria,2UBY6@28211|Alphaproteobacteria,370M6@31993|Methylocystaceae 28211|Alphaproteobacteria KT cheY-homologous receiver domain - - - - - - - - - - - - Response_reg k59_981352_2 1122221.JHVI01000017_gene2020 6.52e-09 62.4 COG0745@1|root,COG0745@2|Bacteria,1WJ10@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus T Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain - - - ko:K07666 ko02020,ko02024,map02020,map02024 M00453 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Trans_reg_C k59_362653_1 1144319.PMI16_03235 1.56e-16 83.2 COG1633@1|root,COG1633@2|Bacteria,1R5XX@1224|Proteobacteria,2WGRU@28216|Betaproteobacteria,476HM@75682|Oxalobacteraceae 28216|Betaproteobacteria S Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - - - - - - - - - - FA_desaturase_2 k59_1264260_1 1380394.JADL01000011_gene3929 3.78e-73 239.0 COG3882@1|root,COG3882@2|Bacteria,1PNPC@1224|Proteobacteria,2TUY2@28211|Alphaproteobacteria,2JVN8@204441|Rhodospirillales 204441|Rhodospirillales Q HAD-superfamily phosphatase subfamily IIIC - - - - - - - - - - - - - k59_813030_1 1128912.GMES_1305 3.16e-56 203.0 COG1629@1|root,COG4774@1|root,COG1629@2|Bacteria,COG4774@2|Bacteria,1NMCN@1224|Proteobacteria,1T1GZ@1236|Gammaproteobacteria,46D8R@72275|Alteromonadaceae 1236|Gammaproteobacteria P TonB dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_1152315_1 1042377.AFPJ01000020_gene2062 2.31e-73 236.0 COG3119@1|root,COG3119@2|Bacteria,1MUJH@1224|Proteobacteria,1RN2V@1236|Gammaproteobacteria 1236|Gammaproteobacteria P COG3119 Arylsulfatase A and related enzymes - - 3.1.6.1 ko:K01130 ko00140,ko00600,map00140,map00600 - R03980,R04856 RC00128,RC00231 ko00000,ko00001,ko01000 - - - Sulfatase,Sulfatase_C k59_587538_1 1121889.AUDM01000013_gene1885 3.57e-39 140.0 COG0318@1|root,COG0318@2|Bacteria,4NEXK@976|Bacteroidetes,1HX5P@117743|Flavobacteriia,2NT95@237|Flavobacterium 976|Bacteroidetes IQ O-succinylbenzoic acid--CoA ligase menE - 6.2.1.26 ko:K01911 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116 R04030 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000 - - - AMP-binding,AMP-binding_C k59_587538_2 1046627.BZARG_314 1.71e-54 181.0 COG1266@1|root,COG1266@2|Bacteria,4NFKV@976|Bacteroidetes,1HY21@117743|Flavobacteriia 976|Bacteroidetes S CAAX amino terminal protease family yyaK - - ko:K07052 - - - - ko00000 - - - Abi k59_925853_1 270374.MELB17_23600 6.88e-19 92.0 COG2199@1|root,COG2200@1|root,COG2199@2|Bacteria,COG2200@2|Bacteria,1RGCV@1224|Proteobacteria,1SJP8@1236|Gammaproteobacteria,46D4Y@72275|Alteromonadaceae 1236|Gammaproteobacteria T signal transduction protein containing a membrane domain, an EAL and a GGDEF domain - - - - - - - - - - - - 7TMR-DISMED2,EAL,GGDEF,PAS,PAS_9,Response_reg,dCache_1,dCache_3 k59_418064_1 586413.CCDL010000004_gene3554 3.3e-12 72.4 COG0840@1|root,COG0840@2|Bacteria,1V47Q@1239|Firmicutes,4HHFA@91061|Bacilli,23MU7@182709|Oceanobacillus 91061|Bacilli NT Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). - - - - - - - - - - - - MCPsignal k59_1379258_1 323848.Nmul_A2361 5.73e-15 75.5 COG3745@1|root,COG3745@2|Bacteria,1MW75@1224|Proteobacteria,2VMT6@28216|Betaproteobacteria,373YU@32003|Nitrosomonadales 28216|Betaproteobacteria U Flp pilus assembly protein RcpC/CpaB cpaB - - ko:K02279 - - - - ko00000,ko02035,ko02044 - - - RcpC,SAF k59_1379258_2 1232683.ADIMK_0486 3.51e-07 57.0 COG4964@1|root,COG4964@2|Bacteria,1MV8G@1224|Proteobacteria,1RQ4U@1236|Gammaproteobacteria,4683Q@72275|Alteromonadaceae 1236|Gammaproteobacteria U Belongs to the GSP D family cpaC - - ko:K02280 - - - - ko00000,ko02035,ko02044 - - - BON,Secretin,T2SS-T3SS_pil_N k59_1209177_1 1354722.JQLS01000005_gene3850 2.83e-57 192.0 COG2271@1|root,COG2271@2|Bacteria,1QVY6@1224|Proteobacteria,2TVPK@28211|Alphaproteobacteria 28211|Alphaproteobacteria G Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 k59_1548704_2 1131266.ARWQ01000009_gene916 1.56e-29 112.0 COG2301@1|root,arCOG00760@2157|Archaea,41S6F@651137|Thaumarchaeota 651137|Thaumarchaeota G HpcH/HpaI aldolase/citrate lyase family - - 4.1.3.34 ko:K01644 ko02020,map02020 - R00362 RC00067,RC01118 ko00000,ko00001,ko01000 - - - HpcH_HpaI k59_1040916_1 1121405.dsmv_3286 1.84e-15 72.4 COG2827@1|root,COG2827@2|Bacteria,1Q604@1224|Proteobacteria,42VTY@68525|delta/epsilon subdivisions,2WRN4@28221|Deltaproteobacteria,2MM3M@213118|Desulfobacterales 28221|Deltaproteobacteria L GIY-YIG catalytic domain - - - ko:K07461 - - - - ko00000 - - - GIY-YIG k59_248380_1 416591.Tlet_1159 1.24e-32 130.0 COG0405@1|root,COG0405@2|Bacteria,2GCYN@200918|Thermotogae 200918|Thermotogae M PFAM Gamma-glutamyltranspeptidase - - 2.3.2.2,3.4.19.13 ko:K00681 ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100 - R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935 RC00064,RC00090,RC00096 ko00000,ko00001,ko01000,ko01002 - - - G_glu_transpept k59_473660_1 1149133.ppKF707_5765 6.4e-52 177.0 COG1300@1|root,COG1300@2|Bacteria,1Q1GN@1224|Proteobacteria,1RR61@1236|Gammaproteobacteria,1YD1J@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria S Stage II sporulation protein M - - - - - - - - - - - - SpoIIM k59_473660_2 1437882.AZRU01000004_gene1864 1.98e-19 87.4 COG1714@1|root,COG1714@2|Bacteria,1RIE9@1224|Proteobacteria,1S566@1236|Gammaproteobacteria,1YDQ0@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria S RDD family - - - - - - - - - - - - RDD k59_191907_1 715451.ambt_13580 6.02e-47 176.0 COG2373@1|root,COG2911@1|root,COG3210@1|root,COG4932@1|root,COG2373@2|Bacteria,COG2911@2|Bacteria,COG3210@2|Bacteria,COG4932@2|Bacteria,1P8N9@1224|Proteobacteria,1T1IH@1236|Gammaproteobacteria,465B9@72275|Alteromonadaceae 1236|Gammaproteobacteria M Bacterial Ig-like domain (group 3) - - - ko:K20276 ko02024,map02024 - - - ko00000,ko00001 - - - Big_3_2,Big_3_3 k59_1095341_1 755731.Clo1100_4015 3.2e-11 63.5 COG0021@1|root,COG0021@2|Bacteria,1TPIB@1239|Firmicutes,25E6C@186801|Clostridia,36UJ4@31979|Clostridiaceae 186801|Clostridia G Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate tkt - 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 - - - Transket_pyr,Transketolase_C,Transketolase_N k59_587566_1 1122137.AQXF01000002_gene106 2.96e-29 115.0 COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,2TR4E@28211|Alphaproteobacteria 28211|Alphaproteobacteria O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner lon - 3.4.21.53 ko:K01338 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - AAA,LON_substr_bdg,Lon_C k59_587566_2 1122137.AQXF01000002_gene105 1.2e-84 259.0 COG1219@1|root,COG1219@2|Bacteria,1MVQK@1224|Proteobacteria,2TS3R@28211|Alphaproteobacteria 28211|Alphaproteobacteria O ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP clpX GO:0000166,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005524,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030163,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0044238,GO:0051301,GO:0070011,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575 - ko:K03544 ko04112,map04112 - - - ko00000,ko00001,ko03110 - - - AAA_2,ClpB_D2-small,zf-C4_ClpX k59_80428_1 1049564.TevJSym_ak00730 4.45e-56 193.0 COG2239@1|root,COG2239@2|Bacteria,1MW24@1224|Proteobacteria,1RNE4@1236|Gammaproteobacteria,1J4XQ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P Acts as a magnesium transporter mgtE - - ko:K06213 - - - - ko00000,ko02000 1.A.26.1 - - CBS,MgtE,MgtE_N k59_248403_1 1415778.JQMM01000001_gene1804 2.19e-88 274.0 COG0508@1|root,COG0508@2|Bacteria,1MUJD@1224|Proteobacteria,1RME0@1236|Gammaproteobacteria,1J4PD@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) sucB GO:0003674,GO:0003824,GO:0004149,GO:0005488,GO:0005504,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0008289,GO:0009060,GO:0009987,GO:0015980,GO:0016417,GO:0016740,GO:0016746,GO:0016747,GO:0016748,GO:0016751,GO:0016999,GO:0017144,GO:0019752,GO:0031405,GO:0031406,GO:0032991,GO:0033293,GO:0036094,GO:0043167,GO:0043168,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045239,GO:0045240,GO:0045252,GO:0045333,GO:0048037,GO:0050662,GO:0055114,GO:0071704,GO:0072350,GO:0097159,GO:0140096,GO:1901363,GO:1901681,GO:1902494,GO:1990204,GO:1990234 2.3.1.61 ko:K00658 ko00020,ko00310,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00032 R02570,R02571,R08549 RC00004,RC02727,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - iAPECO1_1312.APECO1_1352,iECED1_1282.ECED1_0696,iECOK1_1307.ECOK1_0726,iECS88_1305.ECS88_0752,iLF82_1304.LF82_2196,iNRG857_1313.NRG857_03235,iUMN146_1321.UM146_13990,iUTI89_1310.UTI89_C0722 2-oxoacid_dh,Biotin_lipoyl,E3_binding k59_871205_1 411901.BACCAC_01664 8.44e-10 61.6 2A8DZ@1|root,30XFT@2|Bacteria,4PAWR@976|Bacteroidetes,2FXXX@200643|Bacteroidia,4AU0D@815|Bacteroidaceae 976|Bacteroidetes - - - - - - - - - - - - - - - k59_1379290_1 452637.Oter_2641 1.83e-67 218.0 COG0206@1|root,COG0206@2|Bacteria,46UAJ@74201|Verrucomicrobia,3K7KG@414999|Opitutae 414999|Opitutae D Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity ftsZ - - ko:K03531 ko04112,map04112 - - - ko00000,ko00001,ko02048,ko03036,ko04812 - - - FtsZ_C,Tubulin k59_529411_1 1122613.ATUP01000001_gene394 1.18e-159 470.0 COG1680@1|root,COG1680@2|Bacteria,1MVPR@1224|Proteobacteria,2TRFP@28211|Alphaproteobacteria 28211|Alphaproteobacteria V Hydrolyzes N-terminal residues in D-amino acid- containing peptides dap - 3.4.11.19 ko:K01266 - - - - ko00000,ko01000,ko01002 - - - Beta-lactamase,DAP_B k59_1152364_1 1117647.M5M_10790 9.03e-109 328.0 COG0624@1|root,COG0624@2|Bacteria,1MWJS@1224|Proteobacteria,1RZXV@1236|Gammaproteobacteria,1J4HK@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E COG0624 Acetylornithine deacetylase Succinyl-diaminopimelate desuccinylase and related deacylases - - - ko:K13049 - - - - ko00000,ko01000,ko01002 - - - M20_dimer,Peptidase_M20,Peptidase_M28 k59_643310_1 1122921.KB898199_gene2888 9.31e-40 142.0 COG0223@1|root,COG0223@2|Bacteria,1TQ32@1239|Firmicutes,4HART@91061|Bacilli,26RTF@186822|Paenibacillaceae 91061|Bacilli J Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus fmt GO:0003674,GO:0003824,GO:0004479,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006413,GO:0006464,GO:0006518,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016741,GO:0016742,GO:0019538,GO:0019988,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036211,GO:0043043,GO:0043170,GO:0043412,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0046483,GO:0071704,GO:0071951,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 2.1.2.9 ko:K00604 ko00670,ko00970,map00670,map00970 - R03940 RC00026,RC00165 ko00000,ko00001,ko01000 - - iSB619.SA_RS06010 Formyl_trans_C,Formyl_trans_N k59_643310_2 1120948.KB903240_gene3927 3.38e-08 54.3 COG0242@1|root,COG0242@2|Bacteria,2GJ87@201174|Actinobacteria,4DZRR@85010|Pseudonocardiales 201174|Actinobacteria J Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions def - 3.5.1.88 ko:K01462 - - - - ko00000,ko01000 - - - Pep_deformylase k59_981403_1 686340.Metal_2490 7.75e-19 88.6 COG1075@1|root,COG1075@2|Bacteria,1N2W0@1224|Proteobacteria,1S2JW@1236|Gammaproteobacteria,1XG9F@135618|Methylococcales 135618|Methylococcales S Alpha/beta hydrolase family - - - - - - - - - - - - - k59_248422_1 436308.Nmar_0256 2.04e-136 390.0 COG2513@1|root,arCOG00581@2157|Archaea,41SEN@651137|Thaumarchaeota 651137|Thaumarchaeota G Phosphoenolpyruvate phosphomutase - - - - - - - - - - - - PEP_mutase k59_981410_2 314282.PCNPT3_01400 4.11e-31 124.0 COG3307@1|root,COG3307@2|Bacteria,1QR23@1224|Proteobacteria,1SMCP@1236|Gammaproteobacteria,2QHRI@267894|Psychromonadaceae 1236|Gammaproteobacteria M O-Antigen ligase - - - - - - - - - - - - Wzy_C k59_306085_1 42565.FP66_03580 3e-37 140.0 2C593@1|root,2Z84R@2|Bacteria,1Q8PC@1224|Proteobacteria,1RP26@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_306085_2 290398.Csal_1457 2.94e-18 82.8 COG0026@1|root,COG0026@2|Bacteria,1MVHP@1224|Proteobacteria,1RSAE@1236|Gammaproteobacteria,1XHME@135619|Oceanospirillales 135619|Oceanospirillales F Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) - - - - - - - - - - - - - k59_80457_2 392499.Swit_0062 1e-15 76.3 COG1310@1|root,COG1310@2|Bacteria,1NC23@1224|Proteobacteria,2UGM4@28211|Alphaproteobacteria,2K62I@204457|Sphingomonadales 204457|Sphingomonadales L metal-dependent protease of the PAD1 JAB1 superfamily - - - - - - - - - - - - Prok-JAB k59_1434045_1 1120934.KB894411_gene6659 7.46e-20 90.5 COG0587@1|root,COG0587@2|Bacteria,2GJ1P@201174|Actinobacteria,4DYKC@85010|Pseudonocardiales 201174|Actinobacteria L DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase dnaE2 GO:0000731,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006301,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0016020,GO:0018130,GO:0019438,GO:0019985,GO:0030312,GO:0031668,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0042221,GO:0042276,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044464,GO:0046483,GO:0046677,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0071897,GO:0071944,GO:0090304,GO:1901360,GO:1901362,GO:1901576 2.7.7.7 ko:K14162 - - - - ko00000,ko01000,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon k59_1434045_2 522306.CAP2UW1_2122 5.13e-17 82.0 COG0389@1|root,COG0389@2|Bacteria,1MU5X@1224|Proteobacteria,2VIKH@28216|Betaproteobacteria 28216|Betaproteobacteria L Nucleotidyltransferase DNA polymerase involved in DNA repair imuB - - ko:K14161 - - - - ko00000,ko03400 - - - IMS k59_1209237_1 697282.Mettu_3446 3.05e-58 203.0 COG1305@1|root,COG4196@1|root,COG1305@2|Bacteria,COG4196@2|Bacteria,1MVAG@1224|Proteobacteria,1RMX2@1236|Gammaproteobacteria,1XEK9@135618|Methylococcales 135618|Methylococcales E Bacterial transglutaminase-like N-terminal - - - - - - - - - - - - Bact_transglu_N,DUF2126,Transglut_core k59_1661073_1 351348.Maqu_3440 1.08e-53 181.0 COG5345@1|root,COG5345@2|Bacteria,1MWVH@1224|Proteobacteria,1RP5X@1236|Gammaproteobacteria,46486@72275|Alteromonadaceae 1236|Gammaproteobacteria S protein conserved in bacteria - - - - - - - - - - - - DUF2333 k59_587606_1 1131266.ARWQ01000012_gene1614 8.15e-69 215.0 COG1650@1|root,arCOG01616@2157|Archaea,41SM3@651137|Thaumarchaeota 651137|Thaumarchaeota J D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo dtdA - 3.1.1.96 ko:K09716 - - - - ko00000,ko01000,ko03016 - - - tRNA_deacylase k59_587606_2 436308.Nmar_0388 3.6e-55 173.0 COG0350@1|root,arCOG02724@2157|Archaea,41SR8@651137|Thaumarchaeota 651137|Thaumarchaeota L 6-O-methylguanine DNA methyltransferase, DNA binding domain - - 2.1.1.63 ko:K00567 - - - - ko00000,ko01000,ko03400 - - - DNA_binding_1 k59_587606_3 1229909.NSED_01880 1.45e-75 229.0 COG2147@1|root,arCOG04089@2157|Archaea,41SVC@651137|Thaumarchaeota 651137|Thaumarchaeota J Binds to the 23S rRNA rpl19e - - ko:K02885 ko03010,map03010 M00177,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L19e k59_306096_1 84531.JMTZ01000038_gene3596 6.1e-131 413.0 COG2902@1|root,COG2902@2|Bacteria,1MXNV@1224|Proteobacteria,1RQVZ@1236|Gammaproteobacteria,1X46R@135614|Xanthomonadales 135614|Xanthomonadales E glutamate dehydrogenase - - 1.4.1.2 ko:K15371 ko00220,ko00250,ko00430,ko00910,ko01100,map00220,map00250,map00430,map00910,map01100 - R00243 RC00006,RC02799 ko00000,ko00001,ko01000 - - - Bac_GDH,GDH_N k59_1435342_1 94624.Bpet0576 9.55e-05 45.4 COG2264@1|root,COG2264@2|Bacteria,1MUPC@1224|Proteobacteria,2VH76@28216|Betaproteobacteria,3T1NF@506|Alcaligenaceae 28216|Betaproteobacteria J Ribosomal protein L11 methyltransferase prmA - - ko:K02687 - - - - ko00000,ko01000,ko03009 - - - PrmA k59_1435342_2 626887.J057_10736 3e-08 58.2 COG1273@1|root,COG1273@2|Bacteria,1MWCU@1224|Proteobacteria,1RYQ0@1236|Gammaproteobacteria,46705@72275|Alteromonadaceae 1236|Gammaproteobacteria S Protein of unknown function (DUF3426) - - - - - - - - - - - - DUF3426,zinc_ribbon_4,zinc_ribbon_5 k59_419568_2 1215114.BBIU01000016_gene2383 2.63e-45 155.0 COG1057@1|root,COG1057@2|Bacteria,1RD0J@1224|Proteobacteria,1RP00@1236|Gammaproteobacteria 1236|Gammaproteobacteria H Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) nadD GO:0000309,GO:0003674,GO:0003824,GO:0004515,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019365,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0034355,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0043094,GO:0043173,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0070566,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.7.7.18,3.5.4.4 ko:K00969,ko:K01488 ko00230,ko00760,ko01100,ko05340,map00230,map00760,map01100,map05340 M00115 R00137,R01560,R02556,R03005 RC00002,RC00477 ko00000,ko00001,ko00002,ko01000 - - iECUMN_1333.ECUMN_0733,iJN746.PP_4810,iPC815.YPO2607,iSbBS512_1146.SbBS512_E0612 CTP_transf_like k59_25042_1 935839.JAGJ01000008_gene1814 1.17e-23 102.0 COG0358@1|root,COG0358@2|Bacteria,2GJFX@201174|Actinobacteria,4F44X@85017|Promicromonosporaceae 201174|Actinobacteria L RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication dnaG GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 - ko:K02316 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB_bind,DnaG_DnaB_bind,Toprim_4,Toprim_N,zf-CHC2 k59_419570_1 1437824.BN940_14476 1.87e-86 263.0 COG0115@1|root,COG0115@2|Bacteria,1MVB0@1224|Proteobacteria,2VHR7@28216|Betaproteobacteria,3T8SY@506|Alcaligenaceae 28216|Betaproteobacteria E Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family ilvE - 2.6.1.42 ko:K00826 ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00036,M00119,M00570 R01090,R01214,R02199,R10991 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_4 k59_1153889_1 1182590.BN5_03588 4.65e-20 86.3 COG0054@1|root,COG0054@2|Bacteria,1RD9J@1224|Proteobacteria,1S3WD@1236|Gammaproteobacteria,1YEXT@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria H Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin ribH GO:0000906,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.78 ko:K00794 ko00740,ko01100,ko01110,map00740,map01100,map01110 M00125 R04457 RC00960 ko00000,ko00001,ko00002,ko01000 - - iSFV_1184.SFV_0380 DMRL_synthase k59_1153889_2 314285.KT71_01390 2.49e-70 215.0 COG0781@1|root,COG0781@2|Bacteria,1RHFZ@1224|Proteobacteria,1S6AJ@1236|Gammaproteobacteria,1J7VA@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria K Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons nusB GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006353,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576 - ko:K03625 - - - - ko00000,ko03009,ko03021 - - - NusB k59_1153889_3 1121937.AUHJ01000018_gene241 8.55e-13 67.0 COG0611@1|root,COG0611@2|Bacteria,1MU9X@1224|Proteobacteria,1RNHU@1236|Gammaproteobacteria,466CJ@72275|Alteromonadaceae 1236|Gammaproteobacteria H Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 thiL GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009030,GO:0009058,GO:0009108,GO:0009110,GO:0009228,GO:0009229,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0017076,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0035639,GO:0036094,GO:0042357,GO:0042364,GO:0042723,GO:0042724,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046483,GO:0046872,GO:0051186,GO:0051188,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.7.4.16 ko:K00946 ko00730,ko01100,map00730,map01100 M00127 R00617 RC00002 ko00000,ko00001,ko00002,ko01000 - - iSFV_1184.SFV_0382 AIRS,AIRS_C k59_1606923_1 1408813.AYMG01000039_gene2285 8.66e-69 223.0 COG0464@1|root,COG0464@2|Bacteria,4NFWG@976|Bacteroidetes,1IR7U@117747|Sphingobacteriia 976|Bacteroidetes O AAA ATPase central domain protein - - - - - - - - - - - - AAA k59_702675_1 391596.PBAL39_01477 5.16e-17 80.5 COG0382@1|root,COG0382@2|Bacteria,4NIRK@976|Bacteroidetes,1ISIW@117747|Sphingobacteriia 976|Bacteroidetes H UbiA prenyltransferase family - - - - - - - - - - - - UbiA k59_702675_2 391625.PPSIR1_10520 5.37e-46 155.0 COG0300@1|root,COG0300@2|Bacteria,1NGXF@1224|Proteobacteria,42Q5Q@68525|delta/epsilon subdivisions,2WNMS@28221|Deltaproteobacteria,2YV1C@29|Myxococcales 28221|Deltaproteobacteria S COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - - - - - - - - - - - Radical_SAM,adh_short k59_1381157_1 1238182.C882_0004 3.13e-127 374.0 COG2170@1|root,COG2170@2|Bacteria,1MX4N@1224|Proteobacteria,2TR20@28211|Alphaproteobacteria,2JPF7@204441|Rhodospirillales 204441|Rhodospirillales H ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity - - - ko:K06048 - - - - ko00000,ko01000 - - - GCS2 k59_1606930_1 1217718.ALOU01000071_gene5047 4.81e-55 177.0 COG0521@1|root,COG0521@2|Bacteria,1R9W2@1224|Proteobacteria,2VH28@28216|Betaproteobacteria,1K1WX@119060|Burkholderiaceae 28216|Betaproteobacteria H Molybdenum cofactor synthesis domain protein mogA - 2.7.7.75 ko:K03831 ko00790,ko01100,ko04122,map00790,map01100,map04122 - R09726 RC00002 ko00000,ko00001,ko01000 - - - MoCF_biosynth k59_1606930_2 85643.Tmz1t_0478 6.16e-25 97.1 COG1633@1|root,COG1633@2|Bacteria,1RJFW@1224|Proteobacteria,2VT5X@28216|Betaproteobacteria,2KWJT@206389|Rhodocyclales 206389|Rhodocyclales S Rubrerythrin - - - - - - - - - - - - Rubrerythrin k59_25058_1 1122137.AQXF01000003_gene2172 4.25e-67 210.0 COG5385@1|root,COG5385@2|Bacteria,1MVEY@1224|Proteobacteria,2TSE6@28211|Alphaproteobacteria 28211|Alphaproteobacteria S signal transduction histidine kinase MA20_46320 - - ko:K13588 ko02020,ko04112,map02020,map04112 - - - ko00000,ko00001 - - - HPTransfase k59_25058_2 1122137.AQXF01000003_gene2171 8.04e-88 265.0 COG1218@1|root,COG1218@2|Bacteria,1N0GY@1224|Proteobacteria,2TT7B@28211|Alphaproteobacteria 28211|Alphaproteobacteria P 3'(2'),5'-bisphosphate nucleotidase cysQ - 3.1.3.7 ko:K01082 ko00920,ko01100,ko01120,ko01130,map00920,map01100,map01120,map01130 - R00188,R00508 RC00078 ko00000,ko00001,ko01000,ko03016 - - - Inositol_P k59_250193_2 1122137.AQXF01000003_gene2471 1.95e-81 248.0 COG1792@1|root,COG1792@2|Bacteria,1N8ZS@1224|Proteobacteria,2U1FY@28211|Alphaproteobacteria 28211|Alphaproteobacteria M shape-determining protein MreC mreC - - ko:K03570 - - - - ko00000,ko03036 9.B.157.1 - - MreC k59_82289_2 489825.LYNGBM3L_01970 1.44e-27 112.0 COG0659@1|root,COG0659@2|Bacteria,1G1F1@1117|Cyanobacteria,1H92U@1150|Oscillatoriales 1117|Cyanobacteria P Sulfate transporter - - - ko:K03321 - - - - ko00000,ko02000 2.A.53.3 - - STAS,Sulfate_transp k59_982796_1 717774.Marme_0709 3.9e-87 279.0 COG3605@1|root,COG3605@2|Bacteria,1QTTV@1224|Proteobacteria,1T1H2@1236|Gammaproteobacteria,1XHCB@135619|Oceanospirillales 135619|Oceanospirillales T Belongs to the PEP-utilizing enzyme family ptsP - 2.7.3.9 ko:K08484 ko02060,map02060 - - - ko00000,ko00001,ko01000,ko02000 - - - GAF,GAF_2,PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C k59_1042854_1 1484460.JSWG01000009_gene200 1.68e-92 283.0 COG1541@1|root,COG1541@2|Bacteria,4NFFT@976|Bacteroidetes,1HZKR@117743|Flavobacteriia 976|Bacteroidetes H COG1541 Coenzyme F390 synthetase capK - 6.2.1.30 ko:K01912 ko00360,ko01120,ko05111,map00360,map01120,map05111 - R02539 RC00004,RC00014 ko00000,ko00001,ko01000 - - - AMP-binding k59_1381166_1 1007103.AFHW01000005_gene4594 4.72e-23 100.0 COG0707@1|root,COG0707@2|Bacteria,1TQFT@1239|Firmicutes,4HBAQ@91061|Bacilli,26QGD@186822|Paenibacillaceae 91061|Bacilli M Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) murG - 2.4.1.227 ko:K02563 ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112 - R05032,R05662 RC00005,RC00049 ko00000,ko00001,ko01000,ko01011 - GT28 - Glyco_tran_28_C,Glyco_transf_28 k59_530657_1 1088721.NSU_1187 1.24e-124 363.0 COG0438@1|root,COG0438@2|Bacteria,1MUB7@1224|Proteobacteria,2TQQ0@28211|Alphaproteobacteria,2K08Y@204457|Sphingomonadales 204457|Sphingomonadales M glycosyl transferase group 1 - - - - - - - - - - - - Glyco_trans_1_4,Glyco_transf_4 k59_25066_1 2903.EOD35509 2.49e-13 69.7 COG2084@1|root,KOG0409@2759|Eukaryota 2759|Eukaryota I 3hydroxyisobutyrate dehydrogenase - - - - - - - - - - - - NAD_binding_11,NAD_binding_2 k59_25066_2 1454004.AW11_02279 1.44e-16 74.3 COG0662@1|root,COG0662@2|Bacteria,1N1XN@1224|Proteobacteria,2VTSM@28216|Betaproteobacteria 28216|Betaproteobacteria G Cupin domain - - - - - - - - - - - - Cupin_2 k59_1606945_1 84531.JMTZ01000003_gene2364 2.92e-39 150.0 COG1020@1|root,COG1020@2|Bacteria,1QK4F@1224|Proteobacteria,1RPAG@1236|Gammaproteobacteria,1X3AB@135614|Xanthomonadales 135614|Xanthomonadales Q non-ribosomal peptide synthetase - - - - - - - - - - - - AMP-binding,AMP-binding_C,Condensation,PP-binding k59_814235_1 266264.Rmet_2758 1.78e-72 231.0 COG2864@1|root,COG2864@2|Bacteria,1MXFQ@1224|Proteobacteria,2VKTA@28216|Betaproteobacteria,1K1V2@119060|Burkholderiaceae 28216|Betaproteobacteria C formate dehydrogenase fdhC - - ko:K00127 ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200 - R00519 RC02796 ko00000,ko00001 - - - Ni_hydr_CYTB k59_1773974_1 504472.Slin_0947 5.11e-07 53.5 COG0577@1|root,COG0577@2|Bacteria,4NDUK@976|Bacteroidetes,47NWV@768503|Cytophagia 976|Bacteroidetes V MacB-like periplasmic core domain - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_1719661_1 1088721.NSU_1286 1.21e-87 268.0 COG1846@1|root,COG1846@2|Bacteria,1N2Q4@1224|Proteobacteria,2UC5A@28211|Alphaproteobacteria,2K54U@204457|Sphingomonadales 204457|Sphingomonadales K Transcriptional regulator - - - - - - - - - - - - HTH_27,MarR k59_475017_1 1088721.NSU_2185 1.26e-28 112.0 COG0621@1|root,COG0621@2|Bacteria,1MURS@1224|Proteobacteria,2TQN6@28211|Alphaproteobacteria,2K1NH@204457|Sphingomonadales 204457|Sphingomonadales J Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine miaB - 2.8.4.3 ko:K06168 - - R10645,R10646,R10647 RC00003,RC00980,RC03221,RC03222 ko00000,ko01000,ko03016 - - - Radical_SAM,TRAM,UPF0004 k59_475017_2 555793.WSK_2427 4.77e-50 166.0 COG2021@1|root,COG2021@2|Bacteria,1RDEH@1224|Proteobacteria,2U267@28211|Alphaproteobacteria,2K3DI@204457|Sphingomonadales 204457|Sphingomonadales E Alpha/beta hydrolase family - - - - - - - - - - - - Abhydrolase_1,Abhydrolase_6 k59_757458_1 1336208.JADY01000001_gene954 9.96e-15 83.6 COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TQQ9@28211|Alphaproteobacteria 28211|Alphaproteobacteria T Histidine kinase - - - - - - - - - - - - GAF_2,HATPase_c,HisKA,PAS_3,PAS_4,Response_reg k59_982820_1 1274.HX89_03070 9.19e-62 205.0 COG0484@1|root,COG0484@2|Bacteria,2GJKK@201174|Actinobacteria,1ZVET@145357|Dermacoccaceae 201174|Actinobacteria O DnaJ molecular chaperone homology domain dnaJ GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0010468,GO:0016020,GO:0019222,GO:0030312,GO:0040007,GO:0043388,GO:0044093,GO:0044464,GO:0050789,GO:0051098,GO:0051099,GO:0051101,GO:0060255,GO:0065007,GO:0065009,GO:0071944,GO:2000677,GO:2000679 - ko:K03686,ko:K05516 - - - - ko00000,ko03029,ko03036,ko03110 - - - DnaJ,DnaJ_C,DnaJ_CXXCXGXG k59_307926_1 1122214.AQWH01000008_gene1550 7.74e-44 158.0 COG0402@1|root,COG0402@2|Bacteria,1MVPA@1224|Proteobacteria,2TU9F@28211|Alphaproteobacteria 28211|Alphaproteobacteria F Cytosine deaminase and related metal-dependent hydrolases - - - - - - - - - - - - Amidohydro_1 k59_1381210_1 1008459.TASI_0874 4.23e-33 128.0 COG3239@1|root,COG3239@2|Bacteria,1MY4I@1224|Proteobacteria,2VKQE@28216|Betaproteobacteria,3T1K7@506|Alcaligenaceae 28216|Betaproteobacteria I Fatty acid desaturase - - 1.14.19.23,1.14.19.45 ko:K10255 ko02020,map02020 - - - ko00000,ko00001,ko01000,ko01004 - - - FA_desaturase k59_982832_1 1415778.JQMM01000001_gene552 1.18e-115 344.0 COG0706@1|root,COG0706@2|Bacteria,1MV5M@1224|Proteobacteria,1RMH1@1236|Gammaproteobacteria,1J5M7@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins yidC GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006457,GO:0006810,GO:0008104,GO:0008150,GO:0008565,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0016043,GO:0022607,GO:0031224,GO:0031226,GO:0032977,GO:0033036,GO:0034613,GO:0042886,GO:0043933,GO:0044085,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051205,GO:0051234,GO:0051259,GO:0051260,GO:0051641,GO:0061024,GO:0065003,GO:0070727,GO:0071702,GO:0071705,GO:0071840,GO:0071944,GO:0072657,GO:0090150 - ko:K03217 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044,ko03029 2.A.9 - - 60KD_IMP,YidC_periplas k59_873151_1 864069.MicloDRAFT_00048520 1.37e-51 171.0 COG0563@1|root,COG0563@2|Bacteria,1MXCZ@1224|Proteobacteria,2TT6A@28211|Alphaproteobacteria,1JR6T@119045|Methylobacteriaceae 28211|Alphaproteobacteria F Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism adk - 2.7.4.3 ko:K00939 ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130 M00049 R00127,R01547,R11319 RC00002 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ADK,ADK_lid k59_873151_2 926561.KB900619_gene2568 3.69e-92 279.0 COG0024@1|root,COG0024@2|Bacteria,1TQC1@1239|Firmicutes,248I8@186801|Clostridia,3WA6N@53433|Halanaerobiales 186801|Clostridia J TIGRFAM methionine aminopeptidase, type I map - 3.4.11.18 ko:K01265 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M24 k59_873151_3 1229780.BN381_450074 5.14e-47 154.0 COG0099@1|root,COG0099@2|Bacteria,2IHPN@201174|Actinobacteria,3UWMD@52018|unclassified Actinobacteria (class) 201174|Actinobacteria J Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits rpsM GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0019538,GO:0022613,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02952 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S13 k59_137924_1 670487.Ocepr_0952 3.58e-12 65.5 COG0114@1|root,COG0114@2|Bacteria,1WJ9Q@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus C Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate fumC GO:0003674,GO:0003824,GO:0004333,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006106,GO:0006108,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017144,GO:0019752,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0055114,GO:0071704,GO:0072350 4.2.1.2 ko:K01679 ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04934,ko05200,ko05211,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200,map04934,map05200,map05211 M00009,M00011,M00173,M00376 R01082 RC00443 ko00000,ko00001,ko00002,ko01000 - - - FumaraseC_C,Lyase_1 k59_1494494_1 1144310.PMI07_005952 1.2e-46 163.0 COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2TQWK@28211|Alphaproteobacteria,4BACM@82115|Rhizobiaceae 28211|Alphaproteobacteria S protein conserved in bacteria - - - - - - - - - - - - TctC k59_814257_2 1122137.AQXF01000005_gene986 8.4e-24 92.4 COG1725@1|root,COG1725@2|Bacteria,1MZG9@1224|Proteobacteria,2UBQ4@28211|Alphaproteobacteria 28211|Alphaproteobacteria K Transcriptional regulator - - - ko:K07979 - - - - ko00000,ko03000 - - - GntR k59_757476_1 398720.MED217_16960 3.12e-72 236.0 COG4585@1|root,COG4585@2|Bacteria,4NI1V@976|Bacteroidetes,1HWSH@117743|Flavobacteriia,2XJR8@283735|Leeuwenhoekiella 976|Bacteroidetes T Histidine kinase - - - ko:K20971 ko02025,map02025 - - - ko00000,ko00001,ko01001,ko02022 - - - 7TMR-DISMED2,7TMR-DISM_7TM,HATPase_c,HisKA_3,TPR_12 k59_1211198_1 158500.BV97_00615 2.31e-198 568.0 COG1009@1|root,COG1009@2|Bacteria,1MW2M@1224|Proteobacteria,2TQSS@28211|Alphaproteobacteria,2K1DM@204457|Sphingomonadales 204457|Sphingomonadales CP NADH ubiquinone oxidoreductase subunit nuoL - 1.6.5.3 ko:K00341 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - NADH5_C,Proton_antipo_M,Proton_antipo_N k59_927249_1 1157708.KB907450_gene6018 7.56e-31 119.0 COG0624@1|root,COG0624@2|Bacteria,1MW6G@1224|Proteobacteria,2VHRF@28216|Betaproteobacteria,4AB8Q@80864|Comamonadaceae 28216|Betaproteobacteria E Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls dapE - 3.5.1.18 ko:K01439 ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230 M00016 R02734 RC00064,RC00090 ko00000,ko00001,ko00002,ko01000 - - - M20_dimer,Peptidase_M20 k59_927249_2 1121935.AQXX01000144_gene4531 1.59e-47 158.0 COG1495@1|root,COG1495@2|Bacteria,1RIJE@1224|Proteobacteria,1S6WD@1236|Gammaproteobacteria,1XKI8@135619|Oceanospirillales 135619|Oceanospirillales O Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein dsbB - - ko:K03611 - - - - ko00000,ko03110 5.A.2.1 - - DsbB k59_927249_3 1122604.JONR01000078_gene1353 5.81e-20 86.3 COG0704@1|root,COG0704@2|Bacteria,1MUMI@1224|Proteobacteria,1RMW5@1236|Gammaproteobacteria,1X3W0@135614|Xanthomonadales 135614|Xanthomonadales P Plays a role in the regulation of phosphate uptake phoU GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009892,GO:0010563,GO:0010966,GO:0019220,GO:0019222,GO:0031323,GO:0031324,GO:0032879,GO:0034762,GO:0034763,GO:0034765,GO:0034766,GO:0042802,GO:0042803,GO:0043269,GO:0043271,GO:0044070,GO:0044424,GO:0044464,GO:0045936,GO:0046983,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051049,GO:0051051,GO:0051174,GO:0065007,GO:1903792,GO:1903795,GO:1903796,GO:1903959,GO:1903960,GO:2000185,GO:2000186 - ko:K02039 - - - - ko00000 - - - PhoU k59_364749_1 702113.PP1Y_AT25112 3.78e-115 350.0 COG0768@1|root,COG0768@2|Bacteria,1MV8C@1224|Proteobacteria,2TRXN@28211|Alphaproteobacteria,2JZYI@204457|Sphingomonadales 204457|Sphingomonadales M Penicillin-binding Protein mrdA - 3.4.16.4 ko:K05515 ko00550,ko01501,map00550,map01501 - - - ko00000,ko00001,ko01000,ko01011 - - - PBP_dimer,Transpeptidase k59_982842_1 1144275.COCOR_04512 9.63e-30 120.0 COG4948@1|root,COG4948@2|Bacteria,1MU8R@1224|Proteobacteria,42WKH@68525|delta/epsilon subdivisions,2WSGE@28221|Deltaproteobacteria 28221|Deltaproteobacteria H Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB) menC - 4.2.1.113 ko:K02549 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116 R04031 RC01053 ko00000,ko00001,ko00002,ko01000 - - - MR_MLE_C,MR_MLE_N k59_1042927_1 525146.Ddes_1531 8.97e-46 165.0 COG1053@1|root,COG1053@2|Bacteria,1MU5M@1224|Proteobacteria,42M81@68525|delta/epsilon subdivisions,2WJXY@28221|Deltaproteobacteria,2M826@213115|Desulfovibrionales 28221|Deltaproteobacteria C TIGRFAM succinate dehydrogenase or fumarate reductase, flavoprotein subunit sdhA - 1.3.5.1,1.3.5.4 ko:K00239,ko:K00244 ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,ko05134,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020,map05134 M00009,M00011,M00149,M00150,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,Succ_DH_flav_C k59_1435409_1 379066.GAU_2323 1.34e-22 102.0 COG1524@1|root,COG1524@2|Bacteria,1ZUAG@142182|Gemmatimonadetes 142182|Gemmatimonadetes S type I phosphodiesterase nucleotide pyrophosphatase - - - - - - - - - - - - - k59_1153960_1 529709.PYCH_04440 9.4e-53 182.0 COG2403@1|root,arCOG01229@2157|Archaea,2XVYH@28890|Euryarchaeota,24343@183968|Thermococci 183968|Thermococci S CobW/HypB/UreG, nucleotide-binding domain - - - - - - - - - - - - cobW k59_1265642_1 1051632.TPY_0330 0.000717 40.8 COG0197@1|root,COG0197@2|Bacteria,1V1AY@1239|Firmicutes,24FQX@186801|Clostridia,3WCGY@538999|Clostridiales incertae sedis 186801|Clostridia J Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs rplP - - ko:K02878 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L16 k59_1265642_2 933262.AXAM01000052_gene1998 6.89e-06 46.2 COG0255@1|root,COG0255@2|Bacteria,1Q1R3@1224|Proteobacteria,42WYX@68525|delta/epsilon subdivisions,2WSTS@28221|Deltaproteobacteria,2MM8K@213118|Desulfobacterales 28221|Deltaproteobacteria J Belongs to the universal ribosomal protein uL29 family rpmC GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - ko:K02904 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L29 k59_1265642_3 1313421.JHBV01000021_gene4791 5.2e-30 108.0 COG0186@1|root,COG0186@2|Bacteria,4NSB2@976|Bacteroidetes,1IT9T@117747|Sphingobacteriia 976|Bacteroidetes J One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA rpsQ GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02961 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S17 k59_1265642_4 207559.Dde_2247 1.18e-25 97.8 COG0093@1|root,COG0093@2|Bacteria,1RCWZ@1224|Proteobacteria,42RHR@68525|delta/epsilon subdivisions,2WNEK@28221|Deltaproteobacteria,2MBG6@213115|Desulfovibrionales 28221|Deltaproteobacteria J Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome rplN GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070180,GO:0097159,GO:1901363,GO:1990904 - ko:K02874 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L14 k59_1550892_1 349521.HCH_06013 1.4e-58 211.0 COG2202@1|root,COG2203@1|root,COG5001@1|root,COG2202@2|Bacteria,COG2203@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1XHGD@135619|Oceanospirillales 135619|Oceanospirillales T signal transduction protein containing a membrane domain, an EAL and a GGDEF domain - - - - - - - - - - - - EAL,GAF_2,GGDEF,PAS_8,PAS_9,Response_reg k59_1322985_1 1121937.AUHJ01000009_gene1521 2.42e-19 88.2 COG0438@1|root,COG0438@2|Bacteria,1MVIM@1224|Proteobacteria,1RPB8@1236|Gammaproteobacteria,465HY@72275|Alteromonadaceae 1236|Gammaproteobacteria M Glycosyl transferases group 1 - - - - - - - - - - - - Glyco_trans_1_4,Glyco_trans_4_4 k59_1322985_2 685778.AORL01000021_gene783 3.66e-40 143.0 COG2348@1|root,COG2348@2|Bacteria,1MXFY@1224|Proteobacteria,2TTYM@28211|Alphaproteobacteria,2K1U6@204457|Sphingomonadales 204457|Sphingomonadales V Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_6 k59_982845_1 1117318.PRUB_20239 1.58e-05 48.1 2FJ8J@1|root,34AYM@2|Bacteria,1P2ZZ@1224|Proteobacteria,1SSI3@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_1042941_1 713587.THITH_08610 1.41e-114 348.0 COG0556@1|root,COG0556@2|Bacteria,1MUFK@1224|Proteobacteria,1RN6Z@1236|Gammaproteobacteria,1WW4U@135613|Chromatiales 135613|Chromatiales L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage uvrB - - ko:K03702 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - Helicase_C,ResIII,UVR,UvrB k59_927260_1 1415778.JQMM01000001_gene2030 6.36e-77 259.0 COG0642@1|root,COG5001@1|root,COG2205@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1J56I@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T (GGDEF) domain - - - - - - - - - - - - DUF2222,EAL,GGDEF,HAMP,HATPase_c,HisKA,Hpt,PAS_4,Response_reg k59_1607025_1 1288826.MSNKSG1_15846 1.29e-47 160.0 COG0627@1|root,COG0627@2|Bacteria,1MUID@1224|Proteobacteria,1RMR3@1236|Gammaproteobacteria,46528@72275|Alteromonadaceae 1236|Gammaproteobacteria S Serine hydrolase involved in the detoxification of formaldehyde fghA - 3.1.2.12 ko:K01070 ko00680,ko01120,ko01200,map00680,map01120,map01200 - R00527 RC00167,RC00320 ko00000,ko00001,ko01000 - CE1 - Esterase k59_1435420_2 1500257.JQNM01000002_gene4824 3.68e-07 57.8 COG0438@1|root,COG0438@2|Bacteria,1MVKK@1224|Proteobacteria,2TUFG@28211|Alphaproteobacteria,4B91E@82115|Rhizobiaceae 28211|Alphaproteobacteria M Glycosyl transferases group 1 redB - - - - - - - - - - - Glycos_transf_1 k59_137961_1 1500894.JQNN01000001_gene2015 8.32e-63 209.0 COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,2VHGH@28216|Betaproteobacteria,472MA@75682|Oxalobacteraceae 28216|Betaproteobacteria S ABC transporter yheS - - ko:K06158 - - - - ko00000,ko03012 - - - ABC_tran,ABC_tran_CTD,ABC_tran_Xtn k59_1153978_1 314278.NB231_01389 5.87e-08 51.2 COG2919@1|root,COG2919@2|Bacteria,1N7AA@1224|Proteobacteria,1SD8H@1236|Gammaproteobacteria,1WZ9J@135613|Chromatiales 135613|Chromatiales D Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic ftsB - - ko:K05589 - - - - ko00000,ko03036 - - - DivIC k59_1153978_2 565045.NOR51B_2685 1.3e-46 160.0 COG0585@1|root,COG0585@2|Bacteria,1MXHD@1224|Proteobacteria,1RPRF@1236|Gammaproteobacteria 1236|Gammaproteobacteria J Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs truD GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0016070,GO:0016853,GO:0016866,GO:0034641,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360 5.4.99.27 ko:K06176 - - - - ko00000,ko01000,ko03016 - - - TruD k59_644733_1 1122137.AQXF01000002_gene484 2.33e-175 494.0 COG3173@1|root,COG3173@2|Bacteria,1MWAK@1224|Proteobacteria,2TT2N@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Aminoglycoside phosphotransferase - - - - - - - - - - - - APH k59_644733_2 1122137.AQXF01000002_gene485 2.2e-59 189.0 COG1028@1|root,COG1028@2|Bacteria,1MWGC@1224|Proteobacteria,2TSNX@28211|Alphaproteobacteria 28211|Alphaproteobacteria IQ short-chain dehydrogenase - - - - - - - - - - - - adh_short,adh_short_C2 k59_1153979_1 479435.Kfla_5345 3.13e-63 211.0 COG4264@1|root,COG4264@2|Bacteria,2GMS0@201174|Actinobacteria,4DMYI@85009|Propionibacteriales 201174|Actinobacteria Q IucA / IucC family alcC - - - - - - - - - - - Acetyltransf_8,FhuF,IucA_IucC k59_419658_1 1288494.EBAPG3_3880 1.96e-93 278.0 COG0120@1|root,COG0120@2|Bacteria,1MVGR@1224|Proteobacteria,2VH27@28216|Betaproteobacteria,371V1@32003|Nitrosomonadales 28216|Betaproteobacteria G Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate rpiA - 5.3.1.6 ko:K01807 ko00030,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167,M00580 R01056 RC00434 ko00000,ko00001,ko00002,ko01000 - - - Rib_5-P_isom_A,Sugar-bind k59_419658_2 1236959.BAMT01000006_gene314 6.36e-07 50.1 COG0704@1|root,COG0704@2|Bacteria,1MUMI@1224|Proteobacteria,2VI2C@28216|Betaproteobacteria,2KM7N@206350|Nitrosomonadales 206350|Nitrosomonadales P Plays a role in the regulation of phosphate uptake - - - ko:K02039 - - - - ko00000 - - - PhoU k59_1550915_1 682795.AciX8_2200 5.25e-35 137.0 COG0515@1|root,COG0515@2|Bacteria,3Y3NW@57723|Acidobacteria,2JIVS@204432|Acidobacteriia 204432|Acidobacteriia T Protein kinase domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase k59_1720786_1 1479237.JMLY01000001_gene1046 3.07e-15 80.9 COG1752@1|root,COG4775@1|root,COG1752@2|Bacteria,COG4775@2|Bacteria,1MUM9@1224|Proteobacteria,1RRSK@1236|Gammaproteobacteria,468GY@72275|Alteromonadaceae 1236|Gammaproteobacteria M esterase of the alpha-beta hydrolase superfamily plpD - - ko:K07001 - - - - ko00000 - - - Bac_surface_Ag,POTRA,Patatin k59_138970_1 1096930.L284_14285 9.4e-81 261.0 COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TR8X@28211|Alphaproteobacteria,2K1BB@204457|Sphingomonadales 204457|Sphingomonadales T His Kinase A (phosphoacceptor) domain - - 2.7.13.3 ko:K10125 ko02020,map02020 M00504 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA k59_1436150_1 1144305.PMI02_00671 1.87e-98 300.0 COG2124@1|root,COG2124@2|Bacteria,1R599@1224|Proteobacteria,2U0QG@28211|Alphaproteobacteria 28211|Alphaproteobacteria Q cytochrome P-450 CYP112A - - ko:K21116 - - - - ko00000,ko00199 - - - p450 k59_309038_1 1470593.BW43_04429 9.89e-25 106.0 2C7MP@1|root,2Z7Q4@2|Bacteria,1NHK1@1224|Proteobacteria,1RQ17@1236|Gammaproteobacteria 1236|Gammaproteobacteria S COG0500 SAM-dependent methyltransferases PP0279 - - - - - - - - - - - Methyltransf_32 k59_1608088_1 1123400.KB904746_gene1328 3.48e-06 54.7 COG4269@1|root,COG4269@2|Bacteria,1MW5P@1224|Proteobacteria,1RY3G@1236|Gammaproteobacteria,462FN@72273|Thiotrichales 72273|Thiotrichales S Bacterial protein of unknown function (DUF898) - - - - - - - - - - - - DUF898 k59_703815_1 425104.Ssed_0544 1.53e-17 85.9 COG1450@1|root,COG1450@2|Bacteria,1MVNC@1224|Proteobacteria,1RQGJ@1236|Gammaproteobacteria,2Q9FP@267890|Shewanellaceae 1236|Gammaproteobacteria NU Type II and III secretion system protein mshL - - ko:K12282 - - - - ko00000,ko02044 - - - STN,Secretin,Secretin_N_2 k59_590552_1 436308.Nmar_0636 1.22e-66 204.0 arCOG08654@1|root,arCOG08654@2157|Archaea,41SRM@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1436156_1 298655.KI912266_gene5604 4.97e-89 279.0 COG0208@1|root,COG0208@2|Bacteria,2GJKZ@201174|Actinobacteria,4ETJ1@85013|Frankiales 201174|Actinobacteria F P-aminobenzoate N-oxygenase AurF - - - - - - - - - - - - AurF k59_1266646_1 1255043.TVNIR_1873 2.41e-64 212.0 COG0168@1|root,COG0168@2|Bacteria,1MUIJ@1224|Proteobacteria,1RMN6@1236|Gammaproteobacteria,1WWUJ@135613|Chromatiales 135613|Chromatiales P Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA - - - ko:K03498 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - - TrkH k59_1720804_1 1121007.AUML01000019_gene781 4.62e-91 278.0 COG0304@1|root,COG0304@2|Bacteria,4NFBN@976|Bacteroidetes,1HXQ3@117743|Flavobacteriia,2YIV0@290174|Aquimarina 976|Bacteroidetes IQ Beta-ketoacyl synthase, C-terminal domain fabB - 2.3.1.41 ko:K00647 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119 RC00039,RC02728,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Ketoacyl-synt_C,ketoacyl-synt k59_814903_1 1198452.Jab_2c09520 1.41e-47 174.0 COG0642@1|root,COG5001@1|root,COG2205@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,475M1@75682|Oxalobacteraceae 28216|Betaproteobacteria T Putative diguanylate phosphodiesterase - - - - - - - - - - - - EAL,GGDEF,MASE2,PAS_4,PAS_9 k59_1774644_1 1229909.NSED_06400 3.1e-13 70.1 COG3794@1|root,arCOG08764@1|root,arCOG02926@2157|Archaea,arCOG08764@2157|Archaea 2157|Archaea C PFAM blue (type 1) copper domain protein - - - - - - - - - - - - Copper-bind k59_1495629_1 1333998.M2A_1495 4.9e-74 236.0 COG0312@1|root,COG0312@2|Bacteria,1MUVW@1224|Proteobacteria,2TSAV@28211|Alphaproteobacteria,4BPF0@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria S Putative modulator of DNA gyrase pmbA GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0019538,GO:0043170,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:1901564 - ko:K03592 - - - - ko00000,ko01002 - - - PmbA_TldD k59_365871_1 795666.MW7_1348 2.3e-111 337.0 COG0183@1|root,COG0183@2|Bacteria,1MUZV@1224|Proteobacteria,2VMGK@28216|Betaproteobacteria,1KI0E@119060|Burkholderiaceae 28216|Betaproteobacteria I acetyl-coa acetyltransferase - - - - - - - - - - - - Thiolase_C k59_1726828_1 1037409.BJ6T_29010 5.56e-08 59.3 COG1028@1|root,COG1028@2|Bacteria,1N4J7@1224|Proteobacteria,2TSDX@28211|Alphaproteobacteria,3JTR8@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria IQ Enoyl-(Acyl carrier protein) reductase - - - - - - - - - - - - adh_short_C2 k59_1779297_1 439235.Dalk_1565 4.87e-40 148.0 COG2267@1|root,COG2267@2|Bacteria,1MX0N@1224|Proteobacteria,42P9B@68525|delta/epsilon subdivisions,2WMCP@28221|Deltaproteobacteria,2MMBX@213118|Desulfobacterales 28221|Deltaproteobacteria I Alpha/beta hydrolase family - - - - - - - - - - - - Abhydrolase_1,Abhydrolase_4 k59_1668988_1 118005.AWNK01000005_gene1540 7.8e-36 133.0 COG0785@1|root,COG0785@2|Bacteria 2|Bacteria O Cytochrome C biogenesis protein ccdA - 1.8.4.11,1.8.4.12 ko:K06196,ko:K12267 - - - - ko00000,ko01000,ko02000 5.A.1.2 - - AhpC-TSA,DsbD k59_1503001_1 1229909.NSED_01960 8.41e-83 248.0 COG1102@1|root,arCOG01037@2157|Archaea,41SKS@651137|Thaumarchaeota 651137|Thaumarchaeota F Belongs to the cytidylate kinase family. Type 2 subfamily cmk - 2.7.4.25 ko:K00945 ko00240,ko01100,map00240,map01100 M00052 R00158,R00512,R01665 RC00002 ko00000,ko00001,ko00002,ko01000 - - - Cytidylate_kin2 k59_316715_1 485915.Dret_0823 1.45e-33 132.0 COG1067@1|root,COG1340@1|root,COG1067@2|Bacteria,COG1340@2|Bacteria,1MWGB@1224|Proteobacteria,42NJD@68525|delta/epsilon subdivisions,2WJFK@28221|Deltaproteobacteria,2M7U6@213115|Desulfovibrionales 28221|Deltaproteobacteria O Belongs to the peptidase S16 family - - 3.4.21.53 ko:K04076,ko:K04770 - - - - ko00000,ko01000,ko01002 - - - AAA_32,Lon_C,Mg_chelatase k59_90157_1 190650.CC_3412 3.26e-55 178.0 COG3818@1|root,COG3818@2|Bacteria,1RG7T@1224|Proteobacteria,2U8S8@28211|Alphaproteobacteria,2KIY2@204458|Caulobacterales 204458|Caulobacterales S Acetyltransferase (GNAT) domain - - - ko:K06977 - - - - ko00000 - - - Acetyltransf_1 k59_90157_2 1122137.AQXF01000005_gene1167 3.4e-129 372.0 COG1385@1|root,COG1385@2|Bacteria,1MXCU@1224|Proteobacteria,2TS0N@28211|Alphaproteobacteria 28211|Alphaproteobacteria J Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit rsmE - 2.1.1.193 ko:K09761 - - - - ko00000,ko01000,ko03009 - - - Methyltrans_RNA k59_711271_1 1123320.KB889684_gene2291 1.39e-32 122.0 COG3467@1|root,COG3467@2|Bacteria,2GJ76@201174|Actinobacteria 201174|Actinobacteria J Flavin-nucleotide-binding protein - - - ko:K07005 - - - - ko00000 - - - Acetyltransf_3,Pyridox_ox_2 k59_373329_1 436308.Nmar_0848 1.34e-115 342.0 COG1171@1|root,arCOG01431@2157|Archaea,41SCU@651137|Thaumarchaeota 651137|Thaumarchaeota E Pyridoxal-phosphate dependent enzyme - - 4.3.1.19 ko:K01754 ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230 M00570 R00220,R00996 RC00418,RC02600 ko00000,ko00001,ko00002,ko01000 - - - PALP k59_821315_1 1123518.ARWI01000001_gene1639 1.66e-42 158.0 COG2132@1|root,COG2132@2|Bacteria,1PM6Q@1224|Proteobacteria,1RRZJ@1236|Gammaproteobacteria 1236|Gammaproteobacteria Q Parallel beta-helix repeats - - - - - - - - - - - - Cu-oxidase_3 k59_1050725_1 926692.AZYG01000082_gene549 3.7e-37 141.0 COG0296@1|root,COG0296@2|Bacteria,1TP4M@1239|Firmicutes,247WH@186801|Clostridia,3WACD@53433|Halanaerobiales 186801|Clostridia G Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position glgB - 2.4.1.18 ko:K00700 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R02110 - ko00000,ko00001,ko00002,ko01000,ko04147 - CBM48,GH13 - Alpha-amylase,Alpha-amylase_C,CBM_48 k59_651041_2 589865.DaAHT2_0892 1.71e-15 77.8 COG1109@1|root,COG1109@2|Bacteria,1QUGD@1224|Proteobacteria,43BUU@68525|delta/epsilon subdivisions,2WKYP@28221|Deltaproteobacteria,2MPVX@213118|Desulfobacterales 28221|Deltaproteobacteria G Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III - - 5.4.2.2,5.4.2.8 ko:K01835,ko:K01840 ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130 M00114,M00549 R00959,R01057,R01818,R08639 RC00408 ko00000,ko00001,ko00002,ko01000 - - - PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV k59_881704_1 983545.Glaag_2961 1.05e-56 179.0 COG0346@1|root,COG0346@2|Bacteria,1RH8Z@1224|Proteobacteria,1SAVZ@1236|Gammaproteobacteria,467S8@72275|Alteromonadaceae 1236|Gammaproteobacteria E Glyoxalase-like domain - - - - - - - - - - - - Glyoxalase k59_373333_2 314285.KT71_05437 1.14e-20 95.1 COG0457@1|root,COG0457@2|Bacteria,1MVCA@1224|Proteobacteria,1RS02@1236|Gammaproteobacteria,1J82X@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Tetratricopeptide repeat - - - - - - - - - - - - ANAPC3,TPR_16,TPR_8 k59_1779315_1 1353276.JADR01000003_gene2731 2.06e-60 212.0 COG2866@1|root,COG4935@1|root,COG2866@2|Bacteria,COG4935@2|Bacteria,4NEN7@976|Bacteroidetes,1HWMS@117743|Flavobacteriia 976|Bacteroidetes O Metallo-peptidase family M12B Reprolysin-like fpp1 - - - - - - - - - - - CUB,MAM,P_proprotein,Reprolysin_4,fn3 k59_1669007_1 1298593.TOL_2416 9.8e-86 259.0 COG3665@1|root,COG3665@2|Bacteria,1N2KR@1224|Proteobacteria,1RN5H@1236|Gammaproteobacteria,1XIHT@135619|Oceanospirillales 135619|Oceanospirillales S Domain of unknown function (DUF1989) - - - ko:K09967 - - - - ko00000 - - - DUF1989 k59_200983_1 1437882.AZRU01000020_gene6164 2.29e-21 96.3 COG1960@1|root,COG1960@2|Bacteria,1MVJC@1224|Proteobacteria,1RPZ9@1236|Gammaproteobacteria,1YHT6@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria I Acyl-CoA dehydrogenase, C-terminal domain - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_200983_2 1123261.AXDW01000001_gene1146 3.68e-23 98.2 COG2159@1|root,COG2159@2|Bacteria,1RK9M@1224|Proteobacteria,1S78V@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Amidohydrolase - - - - - - - - - - - - Amidohydro_2 k59_1218881_1 550540.Fbal_1831 6.54e-10 61.2 COG1595@1|root,COG1595@2|Bacteria,1RH1M@1224|Proteobacteria,1T0B4@1236|Gammaproteobacteria 1236|Gammaproteobacteria K ECF sigma factor - - - - - - - - - - - - Sigma70_ECF k59_598127_1 565045.NOR51B_103 7.03e-39 149.0 COG4773@1|root,COG4773@2|Bacteria,1QTXJ@1224|Proteobacteria,1T2BS@1236|Gammaproteobacteria,1J9KJ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P COG1629 Outer membrane receptor proteins, mostly Fe transport - - - - - - - - - - - - Plug,TonB_dep_Rec k59_989118_1 1415778.JQMM01000001_gene1522 2.32e-15 76.3 COG2844@1|root,COG2844@2|Bacteria,1MV54@1224|Proteobacteria,1RN5T@1236|Gammaproteobacteria,1J51H@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen glnD GO:0003674,GO:0003824,GO:0006082,GO:0006464,GO:0006520,GO:0006541,GO:0006542,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008773,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016740,GO:0016772,GO:0016779,GO:0019538,GO:0019752,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044283,GO:0046394,GO:0070569,GO:0071704,GO:0140096,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.7.59 ko:K00990 ko02020,map02020 - - - ko00000,ko00001,ko01000 - - - ACT,GlnD_UR_UTase,HD,NTP_transf_2 k59_989118_2 314287.GB2207_01127 4.64e-94 280.0 COG0024@1|root,COG0024@2|Bacteria,1MU99@1224|Proteobacteria,1RMHN@1236|Gammaproteobacteria,1J4C7@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Methionine aminopeptidase map - 3.4.11.18 ko:K01265 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M24 k59_989119_1 1209072.ALBT01000023_gene4048 3.15e-35 124.0 COG1539@1|root,COG1539@2|Bacteria,1MZ8Z@1224|Proteobacteria,1S9B2@1236|Gammaproteobacteria,1FHDQ@10|Cellvibrio 1236|Gammaproteobacteria H Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin folB GO:0003674,GO:0003824,GO:0004150,GO:0005488,GO:0005515,GO:0016829,GO:0016830,GO:0016832,GO:0042802 1.13.11.81,4.1.2.25,5.1.99.8 ko:K01633 ko00790,ko01100,map00790,map01100 M00126,M00840 R03504,R11037,R11073 RC00721,RC00943,RC01479,RC03333,RC03334 ko00000,ko00001,ko00002,ko01000 - - iECDH1ME8569_1439.ECDH1ME8569_2955,iECSE_1348.ECSE_3338,iPC815.YPO0648,iSBO_1134.SBO_2914,iSDY_1059.SDY_3241,iSFxv_1172.SFxv_3403,iUTI89_1310.UTI89_C3494,iYL1228.KPN_03462,ic_1306.c3808 FolB k59_316754_1 317013.NY99_14515 2.13e-15 74.3 COG0745@1|root,COG0745@2|Bacteria,1MY3D@1224|Proteobacteria,1RPKN@1236|Gammaproteobacteria,1X6FY@135614|Xanthomonadales 135614|Xanthomonadales T Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain ompR - - ko:K02483 - - - - ko00000,ko02022 - - - Response_reg,Trans_reg_C k59_536371_1 1229909.NSED_05045 2.9e-23 92.8 arCOG08730@1|root,arCOG08730@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_536371_2 436308.Nmar_1018 5.57e-31 113.0 arCOG10569@1|root,arCOG10569@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_1560188_1 1123290.AUDQ01000026_gene3155 4.41e-66 217.0 COG0281@1|root,COG0281@2|Bacteria,1UYHB@1239|Firmicutes,4HDRG@91061|Bacilli,26EGN@186818|Planococcaceae 91061|Bacilli C Malic enzyme, N-terminal domain mleA - 1.1.1.38 ko:K00027 ko00620,ko01200,ko02020,map00620,map01200,map02020 - R00214 RC00105 ko00000,ko00001,ko01000 - - - 2-Hacid_dh_C,ACT_4,Malic_M,THF_DHG_CYH_C,malic k59_1389963_1 414684.RC1_0412 2.9e-38 145.0 COG4770@1|root,COG4770@2|Bacteria,1P6RE@1224|Proteobacteria,2TRC2@28211|Alphaproteobacteria,2JPYX@204441|Rhodospirillales 204441|Rhodospirillales I COG4770 Acetyl propionyl-CoA carboxylase, alpha subunit - - 6.4.1.3 ko:K01965 ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200 M00373,M00741 R01859 RC00097,RC00609 ko00000,ko00001,ko00002,ko01000 - - - Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2 k59_33768_1 1158318.ATXC01000001_gene36 1.02e-05 53.1 COG0247@1|root,COG0277@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria 2|Bacteria C FAD linked oxidase domain protein - - - - - - - - - - - - FAD_binding_4 k59_1161694_1 1304878.AUGD01000022_gene3734 8.62e-103 315.0 COG0520@1|root,COG0520@2|Bacteria,1MX5B@1224|Proteobacteria,2TVGK@28211|Alphaproteobacteria,3JTGG@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria E Aminotransferase class-V - - - - - - - - - - - - Aminotran_5 k59_33772_1 1123023.JIAI01000011_gene8760 4.41e-51 171.0 COG2344@1|root,COG2344@2|Bacteria,2GMV2@201174|Actinobacteria,4DY6U@85010|Pseudonocardiales 201174|Actinobacteria K Modulates transcription in response to changes in cellular NADH NAD( ) redox state rex GO:0003674,GO:0005488,GO:0005515,GO:0042802 - ko:K01926 - - - - ko00000,ko03000 - - - CoA_binding,Put_DNA-bind_N k59_821376_1 114615.BRADO3881 2.64e-63 216.0 COG0525@1|root,COG0525@2|Bacteria,1MV7B@1224|Proteobacteria,2TS9E@28211|Alphaproteobacteria,3JTU7@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner valS GO:0003674,GO:0003824,GO:0004812,GO:0004832,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006438,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.9 ko:K01873 ko00970,map00970 M00359,M00360 R03665 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1 k59_425656_2 1121896.JMLU01000018_gene2872 3.87e-16 74.7 COG2827@1|root,COG2827@2|Bacteria,4NTI8@976|Bacteroidetes,1I4YS@117743|Flavobacteriia,2NXAC@237|Flavobacterium 976|Bacteroidetes L GIY-YIG catalytic domain - - - ko:K07461 - - - - ko00000 - - - GIY-YIG k59_651096_1 247633.GP2143_09790 4.59e-55 195.0 COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,1RMUR@1236|Gammaproteobacteria 1236|Gammaproteobacteria V Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation - - - ko:K06147 - - - - ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran k59_316796_1 1122135.KB893141_gene83 3.81e-69 230.0 COG0471@1|root,COG0471@2|Bacteria,1MU0K@1224|Proteobacteria,2TSFS@28211|Alphaproteobacteria 28211|Alphaproteobacteria P COG0471 Di- and tricarboxylate transporters - - - - - - - - - - - - CitMHS,Na_sulph_symp,TrkA_C k59_1161717_1 1268239.PALB_29840 2.52e-101 325.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,2Q0X3@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria V COG0841 Cation multidrug efflux pump - - - ko:K03296,ko:K18138 ko01501,ko01503,map01501,map01503 M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000 2.A.6.2 - - ACR_tran k59_1389999_1 1088721.NSU_4189 1.17e-27 105.0 COG0852@1|root,COG0852@2|Bacteria,1MX4B@1224|Proteobacteria,2TSMT@28211|Alphaproteobacteria,2K0IR@204457|Sphingomonadales 204457|Sphingomonadales C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoC - 1.6.5.3 ko:K00332 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_30kDa k59_1389999_2 1248917.ANFX01000031_gene2563 3.64e-103 300.0 COG0377@1|root,COG0377@2|Bacteria,1MUI2@1224|Proteobacteria,2TQK3@28211|Alphaproteobacteria,2K0KE@204457|Sphingomonadales 204457|Sphingomonadales C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoB - 1.6.5.3 ko:K00331 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q6 k59_711361_1 1229909.NSED_08195 9.1e-182 517.0 COG0016@1|root,arCOG00410@2157|Archaea,41S9U@651137|Thaumarchaeota 651137|Thaumarchaeota J Phenylalanyl-tRNA synthetase alpha subunit - - 6.1.1.20 ko:K01889 ko00970,map00970 M00359,M00360 R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_2d k59_1050785_2 400668.Mmwyl1_3730 5.65e-07 53.1 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,1S3PJ@1236|Gammaproteobacteria 1236|Gammaproteobacteria NT Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). - - - - - - - - - - - - MCPsignal k59_316812_2 1131266.ARWQ01000014_gene90 2.57e-101 300.0 COG1575@1|root,arCOG00480@2157|Archaea,41SNA@651137|Thaumarchaeota 651137|Thaumarchaeota H Belongs to the MenA family. Type 1 subfamily - - - - - - - - - - - - - k59_316812_3 1131266.ARWQ01000014_gene92 3.13e-32 115.0 COG0662@1|root,arCOG03003@2157|Archaea,41TAC@651137|Thaumarchaeota 651137|Thaumarchaeota G PFAM Cupin 2, conserved barrel domain protein - - - - - - - - - - - - - k59_711365_1 28072.Nos7524_5048 1.37e-28 121.0 COG0642@1|root,COG0745@1|root,COG2202@1|root,COG2203@1|root,COG2905@1|root,COG0745@2|Bacteria,COG2202@2|Bacteria,COG2203@2|Bacteria,COG2205@2|Bacteria,COG2905@2|Bacteria,1G09B@1117|Cyanobacteria,1HKS3@1161|Nostocales 1117|Cyanobacteria T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - CBS,GAF,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg k59_1161733_1 864051.BurJ1DRAFT_1709 2.26e-18 84.0 COG0705@1|root,COG0705@2|Bacteria,1MYFP@1224|Proteobacteria,2VQB1@28216|Betaproteobacteria,1KKR5@119065|unclassified Burkholderiales 28216|Betaproteobacteria S Eukaryotic integral membrane protein (DUF1751) - - - - - - - - - - - - Rhomboid k59_1443057_1 1463901.JOIY01000001_gene4956 3.94e-45 168.0 COG0542@1|root,COG0542@2|Bacteria,2GJ73@201174|Actinobacteria 201174|Actinobacteria O Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE clpB - - ko:K03695,ko:K03696 ko01100,ko04213,map01100,map04213 - - - ko00000,ko00001,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N k59_1163308_1 316407.1651309 6.78e-197 583.0 COG3209@1|root,COG3209@2|Bacteria,1MVV1@1224|Proteobacteria,1SKYM@1236|Gammaproteobacteria,3XQSX@561|Escherichia 1236|Gammaproteobacteria M Rhs elements have a nonessential function. They may play an important role in the natural ecology of the cell rhsC GO:0006950,GO:0007154,GO:0008150,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0010438,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0042594,GO:0050896,GO:0051716,GO:0071496 - - - - - - - - - - DUF4329,RHS,RHS_repeat k59_990287_2 1146883.BLASA_0006 2.74e-05 47.4 COG5512@1|root,COG5512@2|Bacteria,2GNQ4@201174|Actinobacteria,4ET6F@85013|Frankiales 201174|Actinobacteria S Protein of unknown function (DUF721) - - - - - - - - - - - - DUF721 k59_990287_3 944479.JQLX01000010_gene553 4.29e-09 59.3 COG4198@1|root,COG4198@2|Bacteria,1NPPY@1224|Proteobacteria,42NTB@68525|delta/epsilon subdivisions,2WKNX@28221|Deltaproteobacteria,2M6CZ@213113|Desulfurellales 28221|Deltaproteobacteria S Protein of unknown function (DUF1015) - - - - - - - - - - - - DUF1015 k59_599875_1 1123368.AUIS01000003_gene1577 1.67e-11 63.2 COG1364@1|root,COG1364@2|Bacteria,1MU0T@1224|Proteobacteria,1RNVF@1236|Gammaproteobacteria,2NC14@225057|Acidithiobacillales 225057|Acidithiobacillales E Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate argJ - 2.3.1.1,2.3.1.35 ko:K00620 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028 R00259,R02282 RC00004,RC00064 ko00000,ko00001,ko00002,ko01000 - - - ArgJ k59_599875_2 323850.Shew_3441 1.31e-23 97.4 COG0237@1|root,COG0237@2|Bacteria,1RCXT@1224|Proteobacteria,1S3NR@1236|Gammaproteobacteria,2Q9KS@267890|Shewanellaceae 1236|Gammaproteobacteria H Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A coaE GO:0003674,GO:0003824,GO:0004140,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.1.24 ko:K00859 ko00770,ko01100,map00770,map01100 M00120 R00130 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - iECP_1309.ECP_0104 CoaE k59_1330143_1 913325.N799_09560 4.27e-78 260.0 COG0506@1|root,COG4230@1|root,COG0506@2|Bacteria,COG4230@2|Bacteria,1MV93@1224|Proteobacteria,1RN48@1236|Gammaproteobacteria,1X36U@135614|Xanthomonadales 135614|Xanthomonadales CE Oxidizes proline to glutamate for use as a carbon and nitrogen source putA - 1.2.1.88,1.5.5.2 ko:K13821 ko00250,ko00330,ko01100,ko01110,ko01130,map00250,map00330,map01100,map01110,map01130 - R00245,R00707,R00708,R01253,R04444,R04445,R05051 RC00080,RC00083,RC00216,RC00242,RC00255 ko00000,ko00001,ko01000,ko03000 - - - Aldedh,Pro_dh,Pro_dh-DNA_bdg k59_990288_1 568703.LGG_00096 1.81e-05 50.4 COG1940@1|root,COG1940@2|Bacteria,1UZ80@1239|Firmicutes,4HD5J@91061|Bacilli,3F5ZR@33958|Lactobacillaceae 91061|Bacilli GK ROK family bglK_1 - - - - - - - - - - - ROK k59_1391687_1 391587.KAOT1_09976 2e-133 399.0 COG0457@1|root,COG0457@2|Bacteria,4NFIY@976|Bacteroidetes,1HYA6@117743|Flavobacteriia 976|Bacteroidetes S PFAM Peptidase family M49 - - 3.4.14.4 ko:K01277 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M49 k59_1052016_1 1282360.ABAC460_13055 2.4e-119 352.0 COG2843@1|root,COG2843@2|Bacteria,1P1MG@1224|Proteobacteria,2TV4X@28211|Alphaproteobacteria,2KJQJ@204458|Caulobacterales 28211|Alphaproteobacteria M Capsule synthesis protein - - - ko:K07282 - - - - ko00000 - - - PGA_cap k59_599894_1 1437600.JDUI01000017_gene1592 1.55e-61 204.0 COG0104@1|root,COG0104@2|Bacteria,2GMP4@201174|Actinobacteria,4CZ0U@85004|Bifidobacteriales 201174|Actinobacteria F Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP purA GO:0003674,GO:0003824,GO:0004019,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0040007,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046033,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.4.4 ko:K01939 ko00230,ko00250,ko01100,map00230,map00250,map01100 M00049 R01135 RC00458,RC00459 ko00000,ko00001,ko00002,ko01000 - - - Adenylsucc_synt k59_1330155_1 266264.Rmet_1100 8.54e-22 94.4 COG0215@1|root,COG0215@2|Bacteria,1MV8H@1224|Proteobacteria,2VMQA@28216|Betaproteobacteria,1KBMC@119060|Burkholderiaceae 28216|Betaproteobacteria J DALR_2 - - 6.1.1.16 ko:K01883 ko00970,map00970 M00359,M00360 R03650 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DALR_2,tRNA-synt_1e k59_1330155_2 373994.Riv7116_2277 8.18e-55 175.0 COG0139@1|root,COG0139@2|Bacteria,1G55P@1117|Cyanobacteria,1HQFQ@1161|Nostocales 1117|Cyanobacteria E Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP - - 3.5.4.19 ko:K01496 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04037 RC01055 ko00000,ko00001,ko00002,ko01000 - - - PRA-CH k59_375084_1 393595.ABO_0593 1.23e-35 137.0 COG0769@1|root,COG0769@2|Bacteria,1MU6P@1224|Proteobacteria,1RMD6@1236|Gammaproteobacteria,1XHNY@135619|Oceanospirillales 135619|Oceanospirillales M Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan murE - 6.3.2.13 ko:K01928 ko00300,ko00550,map00300,map00550 - R02788 RC00064,RC00090 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_1220056_1 1121035.AUCH01000014_gene2421 4.51e-11 68.6 COG3170@1|root,COG3170@2|Bacteria,1MXV7@1224|Proteobacteria,2VHX1@28216|Betaproteobacteria,2KUPN@206389|Rhodocyclales 206389|Rhodocyclales NU COG3170 Tfp pilus assembly protein FimV - - - ko:K08086 - - - - ko00000 - - - LysM k59_712987_1 1122194.AUHU01000002_gene2657 6.44e-50 180.0 COG2902@1|root,COG2902@2|Bacteria,1MXNV@1224|Proteobacteria,1RQVZ@1236|Gammaproteobacteria,464UW@72275|Alteromonadaceae 1236|Gammaproteobacteria E COG2902 NAD-specific glutamate dehydrogenase gdhB - 1.4.1.2 ko:K15371 ko00220,ko00250,ko00430,ko00910,ko01100,map00220,map00250,map00430,map00910,map01100 - R00243 RC00006,RC02799 ko00000,ko00001,ko01000 - - - Bac_GDH,GDH_N k59_482328_1 198214.SF3490 1.01e-14 70.5 28J7P@1|root,2Z932@2|Bacteria,1MVXI@1224|Proteobacteria,1RSF1@1236|Gammaproteobacteria 1236|Gammaproteobacteria S dcrb protein dcrB GO:0005575,GO:0005623,GO:0042597,GO:0044464 - - - - - - - - - - DcrB k59_482328_2 316407.85676572 7.51e-134 380.0 COG1738@1|root,COG1738@2|Bacteria,1MVQU@1224|Proteobacteria,1RNX0@1236|Gammaproteobacteria,3XN77@561|Escherichia 1236|Gammaproteobacteria U Involved in the import of queuosine (Q) precursors, required for Q precursor salvage yhhQ GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006725,GO:0006807,GO:0006810,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0016020,GO:0018130,GO:0019438,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0043094,GO:0043174,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046116,GO:0046483,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071702,GO:0071704,GO:0071705,GO:0071944,GO:0072531,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659,GO:1990397 - ko:K09125 - - - - ko00000 - - - Vut_1 k59_1670268_1 497964.CfE428DRAFT_5636 4.04e-68 221.0 COG2308@1|root,COG2308@2|Bacteria,46TR2@74201|Verrucomicrobia 74201|Verrucomicrobia S Circularly permuted ATP-grasp type 2 - - - - - - - - - - - - CP_ATPgrasp_2 k59_537487_1 749414.SBI_02860 1.38e-10 65.9 COG0823@1|root,COG1228@1|root,COG0823@2|Bacteria,COG1228@2|Bacteria,2GMNT@201174|Actinobacteria 201174|Actinobacteria U Periplasmic component of the Tol biopolymer transport system - - - - - - - - - - - - Amidohydro_1,PD40 k59_1104614_1 1122137.AQXF01000001_gene3387 3.28e-126 373.0 COG0144@1|root,COG0144@2|Bacteria,1MWPE@1224|Proteobacteria,2TSIA@28211|Alphaproteobacteria 28211|Alphaproteobacteria J Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB NOP family rsmB - 2.1.1.176 ko:K03500 - - - - ko00000,ko01000,ko03009 - - - Methyltr_RsmB-F,NusB k59_1728104_1 983920.Y88_0466 3.18e-29 121.0 COG4206@1|root,COG4206@2|Bacteria,1R1JF@1224|Proteobacteria,2TZ3C@28211|Alphaproteobacteria,2KEQP@204457|Sphingomonadales 204457|Sphingomonadales H TonB dependent receptor - - - - - - - - - - - - Plug,TonB_dep_Rec k59_1273293_1 748658.KB907320_gene861 5.15e-136 398.0 COG0247@1|root,COG0247@2|Bacteria,1MWTK@1224|Proteobacteria,1RQ9M@1236|Gammaproteobacteria,1WX1I@135613|Chromatiales 135613|Chromatiales C Cysteine-rich domain - - - - - - - - - - - - CCG k59_823086_1 864051.BurJ1DRAFT_0791 1.32e-104 322.0 COG2864@1|root,COG2864@2|Bacteria,1NJEJ@1224|Proteobacteria,2VKG8@28216|Betaproteobacteria 28216|Betaproteobacteria P Cytochrome c554 and c-prime - - - - - - - - - - - - - k59_375100_1 857087.Metme_1702 9.3e-64 205.0 COG1683@1|root,COG3272@1|root,COG1683@2|Bacteria,COG3272@2|Bacteria,1MXYZ@1224|Proteobacteria,1RNMF@1236|Gammaproteobacteria,1XEGF@135618|Methylococcales 135618|Methylococcales S Protein of unknown function (DUF1722) - - - - - - - - - - - - DUF1722,DUF523 k59_537494_1 472759.Nhal_0372 2.31e-93 284.0 COG1260@1|root,COG1260@2|Bacteria,1N0D9@1224|Proteobacteria,1RZ5M@1236|Gammaproteobacteria 1236|Gammaproteobacteria I Myo-inositol-1-phosphate synthase - - 5.5.1.4 ko:K01858 ko00521,ko00562,ko01100,ko01130,map00521,map00562,map01100,map01130 - R07324 RC01804 ko00000,ko00001,ko01000 - - - Inos-1-P_synth k59_1728110_1 748280.NH8B_1415 3.02e-17 76.3 COG2010@1|root,COG2010@2|Bacteria,1RDSI@1224|Proteobacteria,2VQ50@28216|Betaproteobacteria 28216|Betaproteobacteria C cytochrome C norC - - ko:K02305 ko00910,ko01120,map00910,map01120 M00529 R00294 RC02794 ko00000,ko00001,ko00002 3.D.4.10 - - Cytochrom_C k59_1785335_1 1469613.JT55_01265 4.6e-47 161.0 COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,2TS1R@28211|Alphaproteobacteria 28211|Alphaproteobacteria I Belongs to the thiolase family - - 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N k59_1785335_2 1522072.IL54_2653 1.67e-15 77.8 COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,2TS8E@28211|Alphaproteobacteria,2K2HG@204457|Sphingomonadales 204457|Sphingomonadales I 3-hydroxyacyl-CoA dehydrogenase - - 1.1.1.35,4.2.1.17,5.1.2.3 ko:K01782 ko00071,ko00280,ko00281,ko00310,ko00362,ko00380,ko00410,ko00640,ko00650,ko00903,ko00930,ko01040,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00362,map00380,map00410,map00640,map00650,map00903,map00930,map01040,map01100,map01110,map01120,map01130,map01200,map01212 M00032,M00087 R01975,R03026,R03045,R03276,R04137,R04170,R04203,R04204,R04224,R04737,R04738,R04739,R04740,R04741,R04744,R04745,R04746,R04748,R04749,R05066,R05305,R06411,R06412,R06941,R06942,R07935,R07951,R08093,R08094 RC00029,RC00099,RC00117,RC00241,RC00525,RC00831,RC00834,RC00896,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 - - - 3HCDH,3HCDH_N,ECH_1 k59_266127_2 1229909.NSED_00810 5.72e-57 177.0 COG0640@1|root,arCOG00731@2157|Archaea,41T40@651137|Thaumarchaeota 651137|Thaumarchaeota K Bacterial regulatory protein, arsR family - - - - - - - - - - - - HTH_5 k59_380773_1 1122137.AQXF01000004_gene1648 4.53e-110 340.0 COG0489@1|root,COG3206@1|root,COG0489@2|Bacteria,COG3206@2|Bacteria,1MVI9@1224|Proteobacteria,2TT1Y@28211|Alphaproteobacteria 28211|Alphaproteobacteria D protein involved in exopolysaccharide biosynthesis - - - ko:K16554 ko05111,map05111 - - - ko00000,ko00001,ko02000 8.A.3.1 - - AAA_31,GNVR,Wzz k59_432005_2 1411123.JQNH01000001_gene3240 7.19e-53 177.0 COG2513@1|root,COG2513@2|Bacteria,1N4VT@1224|Proteobacteria,2TTP8@28211|Alphaproteobacteria 28211|Alphaproteobacteria G Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate bcpA - - - - - - - - - - - PEP_mutase k59_1169404_1 880073.Calab_3403 7.89e-71 234.0 COG0280@1|root,COG0281@1|root,COG0280@2|Bacteria,COG0281@2|Bacteria,2NNV3@2323|unclassified Bacteria 2|Bacteria C Malic enzyme, NAD binding domain maeB GO:0003674,GO:0003824,GO:0004470,GO:0004473,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016614,GO:0016615,GO:0016616,GO:0030145,GO:0043167,GO:0043169,GO:0046872,GO:0046914,GO:0055114 1.1.1.38,1.1.1.40,2.3.1.8 ko:K00027,ko:K00029,ko:K00625,ko:K04020,ko:K13788 ko00430,ko00620,ko00640,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,ko02020,map00430,map00620,map00640,map00680,map00710,map00720,map01100,map01120,map01200,map02020 M00169,M00172,M00357,M00579 R00214,R00216,R00230,R00921 RC00004,RC00105,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_1637 Malic_M,PTA_PTB,malic k59_1675382_1 1415778.JQMM01000001_gene2035 1.17e-102 316.0 COG0028@1|root,COG0028@2|Bacteria,1QMA9@1224|Proteobacteria,1RRRN@1236|Gammaproteobacteria,1J9TV@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria EH Thiamine pyrophosphate enzyme, central domain - - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_432010_1 1123277.KB893175_gene1423 6.4e-44 161.0 COG4993@1|root,COG4993@2|Bacteria,4NFK0@976|Bacteroidetes 976|Bacteroidetes G Pyrrolo-quinoline quinone - - - - - - - - - - - - PQQ,PQQ_2 k59_324330_1 444861.E3SPM1_9CAUD 4.2e-21 97.1 4QAYA@10239|Viruses,4QYZ1@35237|dsDNA viruses no RNA stage,4QRZE@28883|Caudovirales 28883|Caudovirales - - - - - - - - - - - - - - - k59_151257_1 596152.DesU5LDRAFT_1457 3.88e-45 162.0 COG5362@1|root,COG5362@2|Bacteria,1PYY9@1224|Proteobacteria,435M3@68525|delta/epsilon subdivisions,2WZZT@28221|Deltaproteobacteria,2M981@213115|Desulfovibrionales 28221|Deltaproteobacteria S TIGRFAM Phage - - - - - - - - - - - - - k59_1448898_1 1123355.JHYO01000004_gene2456 1.61e-71 229.0 COG2816@1|root,COG2816@2|Bacteria,1QGCX@1224|Proteobacteria,2TVMG@28211|Alphaproteobacteria,36Y6N@31993|Methylocystaceae 28211|Alphaproteobacteria L NADH pyrophosphatase-like rudimentary NUDIX domain nudC - 3.6.1.22 ko:K03426 ko00760,ko01100,ko04146,map00760,map01100,map04146 - R00103,R03004,R11104 RC00002 ko00000,ko00001,ko01000 - - - NUDIX,NUDIX-like,zf-NADH-PPase k59_41172_2 1229909.NSED_09195 9.72e-61 203.0 COG1782@1|root,arCOG00543@2157|Archaea,41T05@651137|Thaumarchaeota 651137|Thaumarchaeota S RNA-metabolising metallo-beta-lactamase - - - ko:K07041 - - - - ko00000 - - - Beta-Casp,KH_7,Lactamase_B_6,RMMBL k59_1675401_1 1096930.L284_04215 3.78e-82 255.0 COG0438@1|root,COG0438@2|Bacteria,1PDV1@1224|Proteobacteria,2U5AE@28211|Alphaproteobacteria,2K3N1@204457|Sphingomonadales 204457|Sphingomonadales M Glycosyl transferases group 1 - - - - - - - - - - - - Glyco_trans_1_4,Glycos_transf_1 k59_487861_1 399739.Pmen_2625 9.39e-17 77.4 COG1028@1|root,COG1028@2|Bacteria,1MWJQ@1224|Proteobacteria,1RS2P@1236|Gammaproteobacteria,1YDPF@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria IQ Enoyl-(Acyl carrier protein) reductase - - - - - - - - - - - - adh_short k59_487861_2 876044.IMCC3088_258 8.03e-50 164.0 COG3917@1|root,COG3917@2|Bacteria,1MWB9@1224|Proteobacteria,1S4K8@1236|Gammaproteobacteria,1J6A3@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria Q DSBA-like thioredoxin domain - - 5.99.1.4 ko:K14584 ko00626,ko01100,ko01120,ko01220,map00626,map01100,map01120,map01220 M00534 R05137 RC03084 br01602,ko00000,ko00001,ko00002,ko01000 - - - DSBA k59_96891_2 1411685.U062_02067 3.44e-96 288.0 COG0189@1|root,COG0189@2|Bacteria,1MX62@1224|Proteobacteria,1RM8B@1236|Gammaproteobacteria,1J55C@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria F COG0189 Glutathione synthase Ribosomal protein S6 modification enzyme (glutaminyl transferase) rimK GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0016874,GO:0016879,GO:0016881,GO:0018169,GO:0018410,GO:0019538,GO:0031668,GO:0033554,GO:0036211,GO:0042802,GO:0043170,GO:0043412,GO:0043687,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0050896,GO:0051716,GO:0070739,GO:0071496,GO:0071704,GO:0140096,GO:1901564 - ko:K05844 - - - - ko00000,ko01000,ko03009 - - - RimK k59_487863_1 316407.85675781 2.06e-125 393.0 COG3064@1|root,COG3064@2|Bacteria,1N5U6@1224|Proteobacteria,1RYM4@1236|Gammaproteobacteria,3XN17@561|Escherichia 1236|Gammaproteobacteria M N-terminal domain of M60-like peptidases acfD - - ko:K10939 ko05111,map05111 - - - ko00000,ko00001 - - - DUF4092,M60-like_N,Peptidase_M60 k59_1057515_1 330214.NIDE3363 5.33e-38 135.0 COG0811@1|root,COG0811@2|Bacteria,3J0PX@40117|Nitrospirae 40117|Nitrospirae U MotA/TolQ/ExbB proton channel family - - - ko:K03562 ko01120,map01120 - - - ko00000,ko02000 1.A.30.2.2 - - MotA_ExbB k59_1675413_1 436308.Nmar_0843 4.18e-20 85.5 COG1208@1|root,arCOG00663@2157|Archaea,41SIU@651137|Thaumarchaeota 651137|Thaumarchaeota M Nucleotidyl transferase - - - - - - - - - - - - NTP_transferase k59_1785376_1 926550.CLDAP_03790 1.27e-36 128.0 COG0103@1|root,COG0103@2|Bacteria,2G6UZ@200795|Chloroflexi 200795|Chloroflexi J Belongs to the universal ribosomal protein uS9 family rpsI - - ko:K02996 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S9 k59_1785376_2 28042.GU90_05155 1.12e-10 58.9 COG0102@1|root,COG0102@2|Bacteria,2IFG1@201174|Actinobacteria,4E2WQ@85010|Pseudonocardiales 201174|Actinobacteria J This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly rplM GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0019538,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02871 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L13 k59_487873_1 215803.DB30_7204 1.31e-77 253.0 COG0404@1|root,COG0665@1|root,COG0404@2|Bacteria,COG0665@2|Bacteria,1MUXJ@1224|Proteobacteria,42YZ6@68525|delta/epsilon subdivisions,2WU2X@28221|Deltaproteobacteria,2YXQD@29|Myxococcales 28221|Deltaproteobacteria E FAD dependent oxidoreductase central domain - - - - - - - - - - - - DAO,FAO_M,GCV_T,GCV_T_C k59_380814_1 1227739.Hsw_2885 4.67e-50 174.0 COG1262@1|root,COG1262@2|Bacteria,4NF01@976|Bacteroidetes,47JJI@768503|Cytophagia 976|Bacteroidetes S Sulfatase-modifying factor enzyme 1 egtB - - - - - - - - - - - DinB_2,FGE-sulfatase k59_1169446_1 926569.ANT_25720 1.15e-51 171.0 COG4555@1|root,COG4555@2|Bacteria 2|Bacteria CP ABC transporter natA - 3.6.3.7 ko:K09697 ko02010,ko02020,map02010,map02020 M00253 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.115 - iYO844.BSU02750 ABC_tran k59_1169446_2 1384056.N787_11455 6.56e-39 144.0 COG1668@1|root,COG1668@2|Bacteria,1R3RG@1224|Proteobacteria,1RQT1@1236|Gammaproteobacteria,1X3GM@135614|Xanthomonadales 135614|Xanthomonadales CP permease natB - - ko:K09696 ko02010,ko02020,map02010,map02020 M00253 - - ko00000,ko00001,ko00002,ko02000 3.A.1.115 - - ABC2_membrane_2,ABC2_membrane_3 k59_1225454_1 702113.PP1Y_AT12240 2.65e-08 50.1 2DPM9@1|root,332MQ@2|Bacteria,1NAPW@1224|Proteobacteria,2UWJH@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_1568017_1 1229909.NSED_09905 1.08e-97 303.0 COG1293@1|root,arCOG01695@2157|Archaea,41SB0@651137|Thaumarchaeota 651137|Thaumarchaeota K Fibronectin-binding protein A N-terminus (FbpA) - - - - - - - - - - - - DUF814,FbpA k59_1568017_2 1397528.Q671_02410 2.14e-10 63.9 COG1656@1|root,COG1656@2|Bacteria,1R442@1224|Proteobacteria,1S4UH@1236|Gammaproteobacteria 1236|Gammaproteobacteria H Mut7-C RNAse domain - - - ko:K09122 - - - - ko00000 - - - Mut7-C,Ub-Mut7C k59_1397535_1 1547437.LL06_26180 2.2e-104 305.0 COG3335@1|root,COG3335@2|Bacteria,1P76X@1224|Proteobacteria,2VBH8@28211|Alphaproteobacteria,43P72@69277|Phyllobacteriaceae 28211|Alphaproteobacteria L DDE superfamily endonuclease - - - - - - - - - - - - DDE_3 k59_487891_1 436308.Nmar_1684 1.52e-91 281.0 arCOG08795@1|root,arCOG08795@2157|Archaea 2157|Archaea C copper ion binding - - - - - - - - - - - - - k59_995776_1 1469245.JFBG01000019_gene1106 6.33e-70 229.0 COG0441@1|root,COG0441@2|Bacteria,1MUP2@1224|Proteobacteria,1RMYE@1236|Gammaproteobacteria,1WVYK@135613|Chromatiales 135613|Chromatiales J Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) thrS - 6.1.1.3 ko:K01868 ko00970,map00970 M00359,M00360 R03663 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,TGS,tRNA-synt_2b,tRNA_SAD k59_97869_1 1122137.AQXF01000003_gene2355 3.31e-41 142.0 COG2135@1|root,COG2135@2|Bacteria,1RER4@1224|Proteobacteria,2U0W2@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Belongs to the SOS response-associated peptidase family MA20_42060 - - - - - - - - - - - SRAP k59_97869_2 1128421.JAGA01000002_gene1160 2.28e-39 137.0 COG1051@1|root,COG1051@2|Bacteria,2NQ7Y@2323|unclassified Bacteria 2|Bacteria F NUDIX domain - - 3.6.1.55 ko:K03574 - - - - ko00000,ko01000,ko03400 - - - NUDIX k59_97869_3 1248760.ANFZ01000009_gene979 0.000457 41.6 28WVU@1|root,2ZIV5@2|Bacteria,1NGX2@1224|Proteobacteria,2UJJ9@28211|Alphaproteobacteria,2K6RU@204457|Sphingomonadales 204457|Sphingomonadales S Protein of unknown function (DUF2842) - - - - - - - - - - - - DUF2842 k59_1676274_1 1121937.AUHJ01000003_gene3189 2.73e-94 303.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,464AK@72275|Alteromonadaceae 1236|Gammaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_488700_2 1122137.AQXF01000003_gene2434 5.95e-194 562.0 COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,2TS2B@28211|Alphaproteobacteria 28211|Alphaproteobacteria L DNA helicase uvrD - 3.6.4.12 ko:K03657 ko03420,ko03430,map03420,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - UvrD-helicase,UvrD_C k59_1058522_1 1122137.AQXF01000002_gene150 1.45e-39 137.0 COG0315@1|root,COG0315@2|Bacteria,1RCYZ@1224|Proteobacteria,2U747@28211|Alphaproteobacteria 28211|Alphaproteobacteria H Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP) moaC - 4.6.1.17 ko:K03637 ko00790,ko01100,ko04122,map00790,map01100,map04122 - R11372 RC03425 ko00000,ko00001,ko01000 - - - MoaC k59_1336352_1 1120936.KB907222_gene2359 2.39e-10 68.6 COG4585@1|root,COG4585@2|Bacteria,2GMAB@201174|Actinobacteria,4ENFP@85012|Streptosporangiales 201174|Actinobacteria T Histidine kinase - - - - - - - - - - - - HATPase_c,HisKA_3 k59_267156_1 330214.NIDE2235 7.28e-27 114.0 COG3299@1|root,COG3299@2|Bacteria 2|Bacteria S Baseplate J-like protein yqbT1 - - - - - - - - - - - Baseplate_J k59_543826_1 1121013.P873_08670 7.4e-13 66.6 COG3453@1|root,COG3453@2|Bacteria,1N0WC@1224|Proteobacteria,1S8TP@1236|Gammaproteobacteria,1X7C3@135614|Xanthomonadales 135614|Xanthomonadales S Putative phosphatase (DUF442) - - - - - - - - - - - - DUF442 k59_543826_2 83406.HDN1F_05790 2.8e-41 148.0 COG2961@1|root,COG2961@2|Bacteria,1MWGA@1224|Proteobacteria,1RNI1@1236|Gammaproteobacteria,1J5SQ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Specifically methylates the adenine in position 2030 of 23S rRNA rlmJ - 2.1.1.266 ko:K07115 - - - - ko00000,ko01000,ko03009 - - - RsmJ k59_209680_1 653733.Selin_0285 2.81e-38 139.0 COG1215@1|root,COG1215@2|Bacteria 2|Bacteria M transferase activity, transferring glycosyl groups gt2F - 2.4.1.175,2.4.1.226 ko:K13500 ko00532,ko01100,map00532,map01100 - R04603,R05931,R05932,R05933,R05934,R07336 RC00005,RC00049 ko00000,ko00001,ko01000,ko01003 - GT2 - Glyco_transf_7C,Glycos_transf_2 k59_1226234_1 1229909.NSED_06285 2.87e-93 281.0 COG1063@1|root,arCOG01459@2157|Archaea,41S98@651137|Thaumarchaeota 651137|Thaumarchaeota C Glucose dehydrogenase C-terminus - - 1.1.1.14 ko:K00008 ko00040,ko00051,ko01100,map00040,map00051,map01100 M00014 R00875,R01896 RC00085,RC00102 ko00000,ko00001,ko00002,ko01000 - - - ADH_N,ADH_zinc_N k59_1449842_1 1157708.KB907456_gene2319 3.52e-41 151.0 COG0624@1|root,COG0624@2|Bacteria,1MWJS@1224|Proteobacteria,2VHVT@28216|Betaproteobacteria 28216|Betaproteobacteria E Peptidase family M28 - - - - - - - - - - - - M20_dimer,Peptidase_M20,Peptidase_M28 k59_1279792_2 502025.Hoch_4411 2.72e-107 332.0 COG0659@1|root,COG0659@2|Bacteria,1MX8F@1224|Proteobacteria,43AHM@68525|delta/epsilon subdivisions,2X5XU@28221|Deltaproteobacteria,2YU25@29|Myxococcales 28221|Deltaproteobacteria U Sulfate transporter - - - - - - - - - - - - Sulfate_transp k59_1621733_1 216595.PFLU_2321 6.18e-46 160.0 COG0788@1|root,COG0788@2|Bacteria,1MVCF@1224|Proteobacteria,1RN6Q@1236|Gammaproteobacteria,1YM56@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria F Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4) purU - 3.5.1.10 ko:K01433 ko00630,ko00670,map00630,map00670 - R00944 RC00026,RC00111 ko00000,ko00001,ko01000 - - - ACT,Formyl_trans_N k59_890224_1 1198232.CYCME_2010 2.88e-111 339.0 COG3410@1|root,COG3410@2|Bacteria,1PRQ3@1224|Proteobacteria,1RR13@1236|Gammaproteobacteria,46271@72273|Thiotrichales 72273|Thiotrichales S Uncharacterized conserved protein (DUF2075) - - - - - - - - - - - - DUF2075 k59_720147_1 1123237.Salmuc_05264 3.13e-56 186.0 COG3039@1|root,COG3039@2|Bacteria,1MVDK@1224|Proteobacteria,2U0EE@28211|Alphaproteobacteria 28211|Alphaproteobacteria L DDE superfamily endonuclease - - - - - - - - - - - - DDE_Tnp_1,DUF772 k59_1511375_1 1054213.HMPREF9946_02877 1.41e-06 50.8 COG2172@1|root,COG2172@2|Bacteria,1N9RD@1224|Proteobacteria,2UCGB@28211|Alphaproteobacteria,2JTM5@204441|Rhodospirillales 204441|Rhodospirillales T Histidine kinase-like ATPase domain - - - - - - - - - - - - HATPase_c_2 k59_209704_1 565045.NOR51B_2739 1.06e-60 214.0 COG1014@1|root,COG4231@1|root,COG1014@2|Bacteria,COG4231@2|Bacteria,1MUKS@1224|Proteobacteria,1RSEQ@1236|Gammaproteobacteria 1236|Gammaproteobacteria C indolepyruvate ferredoxin oxidoreductase - - 1.2.7.8 ko:K04090 - - - - br01601,ko00000,ko01000 - - - POR,TPP_enzyme_C k59_1449861_1 1117647.M5M_12000 2.66e-39 139.0 COG3264@1|root,COG3264@2|Bacteria,1QUBW@1224|Proteobacteria,1RPXU@1236|Gammaproteobacteria,1J5NH@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M COG0668 Small-conductance mechanosensitive channel - - - ko:K03442 - - - - ko00000,ko02000 1.A.23.2 - - MS_channel,TM_helix k59_1111268_1 342610.Patl_3455 4.01e-36 137.0 COG0477@1|root,COG2814@2|Bacteria,1MU9G@1224|Proteobacteria,1RM9G@1236|Gammaproteobacteria,2Q1A3@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria EGP Uncharacterised MFS-type transporter YbfB ydhP GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K08156,ko:K08159,ko:K18567,ko:K19577 - - - - ko00000,ko02000 2.A.1.2.14,2.A.1.2.15,2.A.1.2.18,2.A.1.2.25,2.A.1.2.65 - - MFS_1,Sugar_tr k59_1336383_1 1408418.JNJH01000060_gene1186 5.61e-61 191.0 COG3385@1|root,COG3385@2|Bacteria,1PMXF@1224|Proteobacteria 1224|Proteobacteria L PFAM transposase, IS4 family protein - - - - - - - - - - - - DDE_Tnp_1,DUF4372 k59_1786354_1 1112274.KI911560_gene1214 1.25e-46 162.0 COG0019@1|root,COG0019@2|Bacteria,1MUA6@1224|Proteobacteria,2VI3M@28216|Betaproteobacteria,2KKUY@206350|Nitrosomonadales 206350|Nitrosomonadales E Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine lysA - 4.1.1.20 ko:K01586 ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R00451 RC00299 ko00000,ko00001,ko00002,ko01000 - - - Orn_Arg_deC_N,Orn_DAP_Arg_deC k59_1111275_2 90813.JQMT01000001_gene237 9.43e-50 164.0 COG0522@1|root,COG0522@2|Bacteria,1MW0U@1224|Proteobacteria,1RQ38@1236|Gammaproteobacteria,4601G@72273|Thiotrichales 72273|Thiotrichales J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit rpsD - - ko:K02986 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S4,S4 k59_1398535_1 396588.Tgr7_3259 6.49e-112 335.0 COG0174@1|root,COG0174@2|Bacteria,1MUGQ@1224|Proteobacteria,1RMD1@1236|Gammaproteobacteria,1WVZ2@135613|Chromatiales 135613|Chromatiales E TIGRFAM glutamine synthetase, type I glnA - 6.3.1.2 ko:K01915 ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 - R00253 RC00010,RC02798 ko00000,ko00001,ko01000,ko04147 - - - Gln-synt_C,Gln-synt_N k59_890270_1 1120956.JHZK01000014_gene1778 2.47e-20 95.5 COG0028@1|root,COG0028@2|Bacteria,1MXDW@1224|Proteobacteria,2TT9X@28211|Alphaproteobacteria 28211|Alphaproteobacteria EH Belongs to the TPP enzyme family - - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_1170332_2 1049564.TevJSym_aw00120 1.18e-53 184.0 COG0493@1|root,COG1143@1|root,COG0493@2|Bacteria,COG1143@2|Bacteria,1MU2H@1224|Proteobacteria,1RREP@1236|Gammaproteobacteria,1J5XD@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster dsrL - - - - - - - - - - - Fer4,Fer4_20,Fer4_7,Fer4_9,NADH_4Fe-4S,Pyr_redox_2 k59_543886_1 1443665.JACA01000005_gene391 1.71e-103 308.0 COG2519@1|root,COG2519@2|Bacteria 2|Bacteria J Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA - - - ko:K20444 - - - - ko00000,ko01000,ko01005,ko02000 4.D.1.3 GT2,GT4 - Glyco_tranf_2_3,Glyco_trans_1_2,Glycos_transf_2,Methyltransf_23,Methyltransf_25,RgpF k59_1398551_1 313598.MED152_09255 5.65e-19 87.8 COG3279@1|root,COG3279@2|Bacteria,4NHUZ@976|Bacteroidetes,1HY5V@117743|Flavobacteriia,3VV95@52959|Polaribacter 976|Bacteroidetes KT LytTr DNA-binding domain - - - - - - - - - - - - LytTR,Response_reg k59_1569035_1 316407.1800064 1.21e-193 539.0 COG0208@1|root,COG0208@2|Bacteria,1MWUS@1224|Proteobacteria,1RN2N@1236|Gammaproteobacteria,3XNJX@561|Escherichia 1236|Gammaproteobacteria F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides nrdF GO:0003674,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005971,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009262,GO:0009263,GO:0009987,GO:0018130,GO:0019438,GO:0019637,GO:0030145,GO:0032991,GO:0034641,GO:0034654,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0055086,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990204 1.17.4.1 ko:K00526 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - iECNA114_1301.ECNA114_2708,iECSF_1327.ECSF_2473,iSFV_1184.SFV_2827,iSF_1195.SF2704,iSFxv_1172.SFxv_2966,iS_1188.S2890 Ribonuc_red_sm k59_433043_1 1380391.JIAS01000012_gene4480 1.42e-15 81.6 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2TQS3@28211|Alphaproteobacteria,2JQ2Z@204441|Rhodospirillales 204441|Rhodospirillales T Putative diguanylate phosphodiesterase - - - - - - - - - - - - EAL,GGDEF,MHYT k59_209733_1 1005048.CFU_3310 6.89e-46 164.0 COG3240@1|root,COG3240@2|Bacteria,1R3US@1224|Proteobacteria,2WEQC@28216|Betaproteobacteria 28216|Betaproteobacteria I GDSL-like Lipase/Acylhydrolase family - - - ko:K11018 - - - - ko00000,ko02042 - - - Lipase_GDSL k59_325250_2 291985.CCSI01000008_gene1071 1.06e-23 100.0 COG2304@1|root,COG2304@2|Bacteria,1MUTS@1224|Proteobacteria,2TSQU@28211|Alphaproteobacteria,2K35S@204457|Sphingomonadales 204457|Sphingomonadales S Domain of unknown function (DUF3520) - - - ko:K07114 - - - - ko00000,ko02000 1.A.13.2.2,1.A.13.2.3 - - DUF3520,VWA,vWF_A k59_1170341_1 1088721.NSU_2471 3.06e-86 274.0 COG4206@1|root,COG4206@2|Bacteria,1R1WX@1224|Proteobacteria,2U0GK@28211|Alphaproteobacteria,2K1DC@204457|Sphingomonadales 204457|Sphingomonadales H receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_607122_1 1088721.NSU_1642 2.84e-46 153.0 COG0454@1|root,COG0456@2|Bacteria,1RH71@1224|Proteobacteria,2UB0M@28211|Alphaproteobacteria 28211|Alphaproteobacteria K Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_1 k59_949295_1 1517416.IDAT_10965 4.62e-10 63.5 COG0454@1|root,COG0456@2|Bacteria,1RH71@1224|Proteobacteria,1S5XH@1236|Gammaproteobacteria,2QFZ8@267893|Idiomarinaceae 1236|Gammaproteobacteria K acetyltransferase - - - - - - - - - - - - Acetyltransf_1 k59_949295_2 1280947.HY30_00410 1.83e-12 66.6 COG3153@1|root,COG3153@2|Bacteria,1RA42@1224|Proteobacteria,2UDUB@28211|Alphaproteobacteria,43YPJ@69657|Hyphomonadaceae 28211|Alphaproteobacteria S Acetyltransferase (GNAT) domain - - - ko:K03824 - - - - ko00000,ko01000 - - - Acetyltransf_1,Acetyltransf_9 k59_441066_1 400668.Mmwyl1_2457 1.02e-93 288.0 COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,1RMBQ@1236|Gammaproteobacteria,1XHTH@135619|Oceanospirillales 135619|Oceanospirillales C Aldehyde dehydrogenase family - - 1.2.1.16,1.2.1.20,1.2.1.79 ko:K00135 ko00250,ko00310,ko00350,ko00650,ko00760,ko01100,ko01120,map00250,map00310,map00350,map00650,map00760,map01100,map01120 M00027 R00713,R00714,R02401 RC00080 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_552076_1 1121374.KB891576_gene765 2.49e-31 115.0 COG4445@1|root,COG4445@2|Bacteria,1QMPR@1224|Proteobacteria,1RYZP@1236|Gammaproteobacteria 1236|Gammaproteobacteria FJ COG4445 Hydroxylase for synthesis of 2-methylthio-cis-ribozeatin in tRNA - - - ko:K06169 - - - - ko00000,ko01000,ko03016 - - - MiaE k59_1741981_1 1528106.JRJE01000006_gene1058 8.06e-37 137.0 COG0845@1|root,COG0845@2|Bacteria,1MW65@1224|Proteobacteria,2VET4@28211|Alphaproteobacteria,2JYMG@204441|Rhodospirillales 204441|Rhodospirillales M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - - - - - - - - - - HlyD_D23 k59_728477_1 883077.HMPREF9241_00335 4.53e-14 74.3 COG0673@1|root,COG0673@2|Bacteria,2GKW0@201174|Actinobacteria,4D7WT@85005|Actinomycetales 201174|Actinobacteria S Oxidoreductase family, NAD-binding Rossmann fold - - - - - - - - - - - - GFO_IDH_MocA k59_728477_2 377629.TERTU_4345 1.27e-39 145.0 28I5V@1|root,2Z891@2|Bacteria,1R94B@1224|Proteobacteria,1RWCK@1236|Gammaproteobacteria,2PMXD@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria M Cellulase N-terminal ig-like domain - - - - - - - - - - - - CelD_N,Glyco_hydro_9 k59_898503_1 243231.GSU1003 3.38e-68 224.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,43U5W@69541|Desulfuromonadales 28221|Deltaproteobacteria T response regulator gnfM - - ko:K07712 ko02020,map02020 M00497 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_1629673_1 1232410.KI421420_gene3133 2.89e-50 173.0 COG0303@1|root,COG0303@2|Bacteria,1MVD5@1224|Proteobacteria,42MZZ@68525|delta/epsilon subdivisions,2WIQI@28221|Deltaproteobacteria,43THW@69541|Desulfuromonadales 28221|Deltaproteobacteria H MoeA domain protein domain I and II moeA-1 - 2.10.1.1 ko:K03750 ko00790,ko01100,map00790,map01100 - R09735 RC03462 ko00000,ko00001,ko01000 - - - MoCF_biosynth,MoeA_C,MoeA_N k59_496488_1 765914.ThisiDRAFT_2285 2.38e-89 275.0 COG0174@1|root,COG0174@2|Bacteria,1MUGQ@1224|Proteobacteria,1RMD1@1236|Gammaproteobacteria,1WVZ2@135613|Chromatiales 135613|Chromatiales E TIGRFAM glutamine synthetase, type I glnA - 6.3.1.2 ko:K01915 ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 - R00253 RC00010,RC02798 ko00000,ko00001,ko01000,ko04147 - - - Gln-synt_C,Gln-synt_N k59_949315_1 84751.XP_007881770.1 3.88e-63 213.0 COG0133@1|root,COG0159@1|root,KOG1395@2759|Eukaryota,KOG4175@2759|Eukaryota,38GS5@33154|Opisthokonta,3NUJ5@4751|Fungi,3UYAJ@5204|Basidiomycota,3N37F@452284|Ustilaginomycotina 4751|Fungi E Tryptophan synthase alpha chain - - 4.2.1.20 ko:K01694,ko:K10882 ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,ko03440,ko03460,map00260,map00400,map01100,map01110,map01130,map01230,map03440,map03460 M00023 R02722 RC00210,RC00700,RC02868 ko00000,ko00001,ko00002,ko01000,ko03400 - - - PALP,Trp_syntA k59_1177832_1 1033737.CAEV01000047_gene1290 4.94e-53 187.0 COG0210@1|root,COG0210@2|Bacteria,1TPSU@1239|Firmicutes,247RM@186801|Clostridia,36DGD@31979|Clostridiaceae 186801|Clostridia L ATP-dependent DNA helicase pcrA - 3.6.4.12 ko:K03657 ko03420,ko03430,map03420,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - UvrD-helicase,UvrD_C k59_1066174_1 926559.JoomaDRAFT_1165 3.06e-86 270.0 COG0657@1|root,COG2755@1|root,COG0657@2|Bacteria,COG2755@2|Bacteria,4NKE5@976|Bacteroidetes,1HZ6S@117743|Flavobacteriia 976|Bacteroidetes E GDSL family lipase rhgT_1 - - - - - - - - - - - Lipase_GDSL_2,Polysacc_deac_1 k59_275404_1 877418.ATWV01000005_gene2623 6.63e-96 301.0 COG0480@1|root,COG0480@2|Bacteria,2J5M8@203691|Spirochaetes 203691|Spirochaetes J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome fusA - - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2 k59_898525_1 1304275.C41B8_08790 4.98e-28 114.0 COG0795@1|root,COG0795@2|Bacteria,1MVW3@1224|Proteobacteria,1RM8H@1236|Gammaproteobacteria 1236|Gammaproteobacteria S permease lptG - - ko:K11720 ko02010,map02010 M00320 - - ko00000,ko00001,ko00002,ko02000 1.B.42.1 - - YjgP_YjgQ k59_898525_2 1089439.KB902240_gene750 2.58e-07 52.8 COG0795@1|root,COG0795@2|Bacteria,1MUF2@1224|Proteobacteria,1RMN5@1236|Gammaproteobacteria,460RT@72273|Thiotrichales 72273|Thiotrichales S Permease YjgP YjgQ - - - ko:K07091 ko02010,map02010 M00320 - - ko00000,ko00001,ko00002,ko02000 1.B.42.1 - - YjgP_YjgQ k59_275407_1 398580.Dshi_2295 4.95e-75 243.0 COG1228@1|root,COG1228@2|Bacteria,1MVAF@1224|Proteobacteria,2TTYC@28211|Alphaproteobacteria 28211|Alphaproteobacteria Q COG1228 Imidazolonepropionase and related amidohydrolases - - - - - - - - - - - - Amidohydro_1 k59_160208_1 1045856.EcWSU1_03719 4.32e-31 120.0 COG0021@1|root,COG0021@2|Bacteria,1MUEY@1224|Proteobacteria,1RMWP@1236|Gammaproteobacteria,3X1Z1@547|Enterobacter 1236|Gammaproteobacteria H Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate tktA GO:0000302,GO:0003674,GO:0003824,GO:0004802,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006098,GO:0006139,GO:0006355,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009052,GO:0009117,GO:0009635,GO:0009636,GO:0009719,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010033,GO:0010035,GO:0010243,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016740,GO:0016744,GO:0019219,GO:0019222,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0019842,GO:0030145,GO:0030976,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032991,GO:0033554,GO:0034599,GO:0034614,GO:0034641,GO:0035690,GO:0036094,GO:0036245,GO:0042221,GO:0042493,GO:0042542,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045893,GO:0045935,GO:0046483,GO:0046496,GO:0046677,GO:0046872,GO:0046914,GO:0048037,GO:0048518,GO:0048522,GO:0050662,GO:0050789,GO:0050794,GO:0050896,GO:0051156,GO:0051171,GO:0051173,GO:0051186,GO:0051252,GO:0051254,GO:0051716,GO:0055086,GO:0060255,GO:0065007,GO:0070301,GO:0070887,GO:0071236,GO:0071310,GO:0071417,GO:0071495,GO:0071704,GO:0072524,GO:0072747,GO:0072756,GO:0080090,GO:0097159,GO:0097237,GO:1901135,GO:1901322,GO:1901360,GO:1901363,GO:1901562,GO:1901564,GO:1901654,GO:1901655,GO:1901681,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 - - iSDY_1059.SDY_3141,iYL1228.KPN_01127 Transket_pyr,Transketolase_C,Transketolase_N k59_441099_1 1136163.M565_ctg1P0383 0.000101 42.4 COG0347@1|root,COG0347@2|Bacteria,1RI28@1224|Proteobacteria,1S62Z@1236|Gammaproteobacteria,1XXA8@135623|Vibrionales 135623|Vibrionales K Belongs to the P(II) protein family VV0993 - - - - - - - - - - - - k59_441099_2 697282.Mettu_1569 2.38e-50 164.0 COG2905@1|root,COG2905@2|Bacteria,1MZGY@1224|Proteobacteria,1S86K@1236|Gammaproteobacteria,1XF65@135618|Methylococcales 135618|Methylococcales T Domain in cystathionine beta-synthase and other proteins. - - - - - - - - - - - - CBS k59_390245_1 448385.sce9075 2.58e-25 110.0 COG1668@1|root,COG1668@2|Bacteria,1R62N@1224|Proteobacteria 1224|Proteobacteria CP COG1668 ABC-type Na efflux pump, permease component - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_3 k59_552100_1 1236541.BALL01000005_gene955 7.99e-21 95.1 COG0457@1|root,COG0457@2|Bacteria,1MXK4@1224|Proteobacteria,1RNFM@1236|Gammaproteobacteria,2Q93B@267890|Shewanellaceae 1236|Gammaproteobacteria S Oxygen tolerance batD - - - - - - - - - - - BatD k59_839210_1 1415780.JPOG01000001_gene64 7.74e-27 107.0 COG2258@1|root,COG2258@2|Bacteria,1RE2Q@1224|Proteobacteria,1SEFF@1236|Gammaproteobacteria 1236|Gammaproteobacteria S MOSC domain - - - - - - - - - - - - - k59_1005953_1 391603.FBALC1_13912 7.45e-112 326.0 COG0811@1|root,COG0811@2|Bacteria,4NFIX@976|Bacteroidetes,1HXWI@117743|Flavobacteriia 976|Bacteroidetes U Mota tolq exbb proton channel exbB - - ko:K03561 - - - - ko00000,ko02000 1.A.30.2.1 - - MotA_ExbB k59_1578054_1 1221522.B723_21945 1.08e-73 230.0 COG2853@1|root,COG2853@2|Bacteria,1MVX0@1224|Proteobacteria,1S3F1@1236|Gammaproteobacteria,1YPBK@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria M VacJ family lipoprotein - - - ko:K04754 - - - - ko00000 - - - MlaA k59_899552_1 1121396.KB893097_gene4347 4.43e-09 56.6 COG2197@1|root,COG2197@2|Bacteria,1R9GN@1224|Proteobacteria,42ZGR@68525|delta/epsilon subdivisions,2WV0D@28221|Deltaproteobacteria,2MNAJ@213118|Desulfobacterales 28221|Deltaproteobacteria KT helix_turn_helix, Lux Regulon - - - - - - - - - - - - GerE,Response_reg k59_899552_2 216591.BCAM0218 8.83e-12 69.7 COG0642@1|root,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,2VGZQ@28216|Betaproteobacteria,1K1KS@119060|Burkholderiaceae 28216|Betaproteobacteria T Histidine kinase - - 2.7.13.3 ko:K07677 ko02020,ko02026,map02020,map02026 M00474 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA,Hpt,Response_reg k59_1005959_1 485913.Krac_3320 5.4e-05 43.9 COG1733@1|root,COG1733@2|Bacteria 2|Bacteria K regulation of RNA biosynthetic process - - - - - - - - - - - - HxlR k59_1005959_2 43151.ADAC004262-PA 8.28e-12 66.6 2B1WH@1|root,2S0BD@2759|Eukaryota,3A1YK@33154|Opisthokonta,3BPKE@33208|Metazoa,3DA7S@33213|Bilateria,420UJ@6656|Arthropoda,3SN92@50557|Insecta,453FQ@7147|Diptera,45IJZ@7148|Nematocera 33208|Metazoa I Microsomal glutathione MGST1 GO:0000003,GO:0000323,GO:0001775,GO:0002237,GO:0002252,GO:0002263,GO:0002274,GO:0002275,GO:0002283,GO:0002366,GO:0002376,GO:0002443,GO:0002444,GO:0002446,GO:0003006,GO:0003674,GO:0003824,GO:0004364,GO:0004601,GO:0004602,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005739,GO:0005740,GO:0005741,GO:0005764,GO:0005765,GO:0005766,GO:0005773,GO:0005774,GO:0005777,GO:0005778,GO:0005783,GO:0005789,GO:0005886,GO:0006518,GO:0006575,GO:0006749,GO:0006790,GO:0006805,GO:0006807,GO:0006810,GO:0006887,GO:0006950,GO:0006955,GO:0006979,GO:0006982,GO:0007275,GO:0007548,GO:0008150,GO:0008152,GO:0008406,GO:0008584,GO:0009058,GO:0009410,GO:0009605,GO:0009607,GO:0009617,GO:0009636,GO:0009987,GO:0010033,GO:0010243,GO:0012505,GO:0012506,GO:0016020,GO:0016021,GO:0016043,GO:0016192,GO:0016209,GO:0016491,GO:0016684,GO:0016740,GO:0016765,GO:0019867,GO:0022414,GO:0022607,GO:0030141,GO:0030154,GO:0030659,GO:0030667,GO:0031090,GO:0031224,GO:0031410,GO:0031903,GO:0031966,GO:0031967,GO:0031968,GO:0031975,GO:0031982,GO:0031984,GO:0032496,GO:0032501,GO:0032502,GO:0032940,GO:0033194,GO:0033218,GO:0033327,GO:0033554,GO:0033993,GO:0034599,GO:0034641,GO:0035577,GO:0036230,GO:0042119,GO:0042175,GO:0042221,GO:0042277,GO:0042493,GO:0042579,GO:0042582,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043207,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043295,GO:0043299,GO:0043312,GO:0043603,GO:0043933,GO:0044085,GO:0044237,GO:0044249,GO:0044272,GO:0044422,GO:0044424,GO:0044425,GO:0044429,GO:0044432,GO:0044433,GO:0044437,GO:0044438,GO:0044439,GO:0044444,GO:0044446,GO:0044464,GO:0045055,GO:0045137,GO:0045177,GO:0045321,GO:0046546,GO:0046661,GO:0046903,GO:0046983,GO:0048037,GO:0048513,GO:0048608,GO:0048731,GO:0048856,GO:0048869,GO:0050896,GO:0051179,GO:0051186,GO:0051234,GO:0051259,GO:0051260,GO:0051704,GO:0051707,GO:0051716,GO:0055114,GO:0061458,GO:0065003,GO:0070206,GO:0070207,GO:0070887,GO:0071447,GO:0071449,GO:0071466,GO:0071704,GO:0071840,GO:0071944,GO:0072341,GO:0097237,GO:0097708,GO:0098588,GO:0098754,GO:0098805,GO:0098827,GO:0098852,GO:0098869,GO:0099503,GO:1900750,GO:1901564,GO:1901566,GO:1901576,GO:1901681,GO:1901685,GO:1901687,GO:1901698,GO:1901700,GO:1901701,GO:1990748 2.5.1.18 ko:K00799 ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418 - R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905 RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944 ko00000,ko00001,ko01000,ko02000 1.A.12.2.2,1.A.12.3.2 - - MAPEG k59_1795433_1 1209072.ALBT01000033_gene1558 5.25e-05 43.9 2CHAX@1|root,32ZC9@2|Bacteria,1N6X2@1224|Proteobacteria,1SCXD@1236|Gammaproteobacteria,1FHM8@10|Cellvibrio 1236|Gammaproteobacteria S Protein of unknown function (DUF3301) - - - - - - - - - - - - DUF3301 k59_839223_1 1120970.AUBZ01000029_gene1055 4.4e-62 214.0 COG1251@1|root,COG1251@2|Bacteria,1MW58@1224|Proteobacteria,1RNGY@1236|Gammaproteobacteria,465T8@72275|Alteromonadaceae 1236|Gammaproteobacteria C Pyridine nucleotide-disulphide oxidoreductase - - 1.7.1.15 ko:K00362 ko00910,ko01120,map00910,map01120 M00530 R00787 RC00176 ko00000,ko00001,ko00002,ko01000 - - - Fer2_BFD,Pyr_redox_2 k59_1743050_1 1288494.EBAPG3_8050 3.72e-43 150.0 COG1475@1|root,COG1475@2|Bacteria,1MW2E@1224|Proteobacteria,2VIG0@28216|Betaproteobacteria,3726M@32003|Nitrosomonadales 28216|Betaproteobacteria K Belongs to the ParB family parB - - ko:K03497 - - - - ko00000,ko03000,ko03036,ko04812 - - - ParBc k59_1743050_2 1177179.A11A3_14572 1.42e-13 69.7 COG1192@1|root,COG1192@2|Bacteria,1MV43@1224|Proteobacteria,1RNJK@1236|Gammaproteobacteria,1XHC3@135619|Oceanospirillales 135619|Oceanospirillales D Chromosome partitioning parA - - ko:K03496 - - - - ko00000,ko03036,ko04812 - - - AAA_31 k59_950294_1 1485544.JQKP01000002_gene1376 1.55e-43 162.0 COG3419@1|root,COG3419@2|Bacteria,1NUAV@1224|Proteobacteria,2VHY8@28216|Betaproteobacteria,44V4V@713636|Nitrosomonadales 28216|Betaproteobacteria NU Neisseria PilC beta-propeller domain pilY1 - - ko:K02674 - - - - ko00000,ko02035,ko02044 - - - Neisseria_PilC k59_950302_1 1415778.JQMM01000001_gene1759 5.76e-34 130.0 COG0405@1|root,COG0405@2|Bacteria,1MUV6@1224|Proteobacteria,1RMIT@1236|Gammaproteobacteria,1J5I7@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M COG0405 Gamma-glutamyltransferase ggt GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0006082,GO:0006508,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0008242,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016787,GO:0019538,GO:0019752,GO:0030288,GO:0030313,GO:0031975,GO:0034722,GO:0036374,GO:0042597,GO:0043094,GO:0043102,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0070011,GO:0071704,GO:0097264,GO:0140096,GO:1901564,GO:1901566,GO:1901576 2.3.2.2,3.4.19.13 ko:K00681 ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100 - R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935 RC00064,RC00090,RC00096 ko00000,ko00001,ko01000,ko01002 - - iAPECO1_1312.APECO1_3012,iECOK1_1307.ECOK1_3869,iECS88_1305.ECS88_3844,iECW_1372.ECW_m3706,iEKO11_1354.EKO11_0296,iETEC_1333.ETEC_3693,iUMN146_1321.UM146_17325,iUTI89_1310.UTI89_C3954,iWFL_1372.ECW_m3706 G_glu_transpept k59_950302_2 688269.Theth_1508 0.000179 45.1 COG1168@1|root,COG2153@1|root,COG1168@2|Bacteria,COG2153@2|Bacteria,2GCM9@200918|Thermotogae 200918|Thermotogae E aminotransferase class I and II - - 4.4.1.8 ko:K14155 ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230 - R00782,R01286,R02408,R04941 RC00056,RC00069,RC00382,RC00488,RC00710,RC01245,RC02303 ko00000,ko00001,ko01000,ko01007 - - - Acetyltransf_10,Aminotran_1_2 k59_391372_1 1144307.PMI04_00182 1.08e-35 132.0 COG1541@1|root,COG1541@2|Bacteria,1NT0G@1224|Proteobacteria,2UP2C@28211|Alphaproteobacteria,2K9AS@204457|Sphingomonadales 204457|Sphingomonadales H Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA) - - - - - - - - - - - - - k59_616335_1 935863.AWZR01000004_gene415 1.1e-14 78.6 COG4773@1|root,COG4773@2|Bacteria,1QTXJ@1224|Proteobacteria,1T2I5@1236|Gammaproteobacteria,1X59N@135614|Xanthomonadales 135614|Xanthomonadales P TonB dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_276546_2 1196083.SALWKB12_0611 0.000816 42.4 COG0544@1|root,COG0544@2|Bacteria,1MUJP@1224|Proteobacteria,2VING@28216|Betaproteobacteria,2KPE2@206351|Neisseriales 206351|Neisseriales D Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase tig GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - ko:K03545 - - - - ko00000 - - - FKBP_C,Trigger_C,Trigger_N k59_899567_2 887062.HGR_09945 1.97e-40 144.0 COG0834@1|root,COG0834@2|Bacteria,1R493@1224|Proteobacteria,2WEVU@28216|Betaproteobacteria,4AGSG@80864|Comamonadaceae 28216|Betaproteobacteria ET Bacterial periplasmic substrate-binding proteins - - - - - - - - - - - - SBP_bac_3 k59_1120031_1 1122137.AQXF01000003_gene2309 8.25e-94 281.0 COG0157@1|root,COG0157@2|Bacteria,1MW0C@1224|Proteobacteria,2TS7C@28211|Alphaproteobacteria 28211|Alphaproteobacteria H Belongs to the NadC ModD family nadC - 2.4.2.19 ko:K00767 ko00760,ko01100,map00760,map01100 M00115 R03348 RC02877 ko00000,ko00001,ko00002,ko01000 - - - QRPTase_C,QRPTase_N k59_1289438_1 1123037.AUDE01000017_gene2499 1.54e-99 308.0 COG1053@1|root,COG1053@2|Bacteria,4NFDU@976|Bacteroidetes,1HWUS@117743|Flavobacteriia 976|Bacteroidetes C SdhA B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC D which are the membrane components and form cytochrome b556 sdhA - 1.3.5.1,1.3.5.4 ko:K00239 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134 M00009,M00011,M00149,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,Succ_DH_flav_C k59_1289438_2 391587.KAOT1_14017 3.49e-17 78.2 COG0479@1|root,COG0479@2|Bacteria,4NFR3@976|Bacteroidetes,1HYVV@117743|Flavobacteriia 976|Bacteroidetes C Succinate dehydrogenase fumarate reductase Fe-S protein subunit frdB - 1.3.5.1,1.3.5.4 ko:K00240 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00149,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 - - - Fer2_3,Fer4_7,Fer4_8 k59_1630781_1 1122137.AQXF01000001_gene2920 1.86e-47 157.0 COG1514@1|root,COG1514@2|Bacteria,1RDB2@1224|Proteobacteria,2U7FV@28211|Alphaproteobacteria 28211|Alphaproteobacteria J Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester ligT - 3.1.4.58 ko:K01975 - - - - ko00000,ko01000,ko03016 - - - LigT_PEase k59_1630781_2 1122137.AQXF01000001_gene2922 6.97e-43 145.0 COG2755@1|root,COG2755@2|Bacteria,1RCXZ@1224|Proteobacteria,2U74E@28211|Alphaproteobacteria 28211|Alphaproteobacteria E COG2755 Lysophospholipase L1 and related esterases tesA - 3.1.1.5 ko:K10804 ko01040,map01040 - - - ko00000,ko00001,ko01000,ko01004 - - - Lipase_GDSL_2 k59_729583_1 1122137.AQXF01000005_gene1284 1.71e-78 247.0 COG1473@1|root,COG1473@2|Bacteria,1MUIV@1224|Proteobacteria,2TR5B@28211|Alphaproteobacteria 28211|Alphaproteobacteria S amidohydrolase - - - - - - - - - - - - M20_dimer,Peptidase_M20 k59_950318_1 323261.Noc_0531 2.92e-76 233.0 COG4094@1|root,COG4094@2|Bacteria,1RDHB@1224|Proteobacteria,1S78U@1236|Gammaproteobacteria,1WVZ8@135613|Chromatiales 135613|Chromatiales S PFAM NnrU protein - - - - - - - - - - - - NnrU k59_1289443_1 1229909.NSED_07115 1.4e-139 427.0 COG2132@1|root,COG3391@1|root,COG3794@1|root,arCOG02562@2157|Archaea,arCOG02926@2157|Archaea,arCOG03914@2157|Archaea 2157|Archaea Q Multicopper - - - - - - - - - - - - Lactonase k59_1686109_1 1121861.KB899928_gene1512 3.81e-38 135.0 COG0454@1|root,COG0454@2|Bacteria,1RDBA@1224|Proteobacteria,2TTF2@28211|Alphaproteobacteria,2JSK2@204441|Rhodospirillales 204441|Rhodospirillales K COG0454 Histone acetyltransferase HPA2 and related acetyltransferases - - - - - - - - - - - - Acetyltransf_1 k59_1686109_2 630626.EBL_c11060 5.39e-26 97.4 COG3530@1|root,COG3530@2|Bacteria,1N7GT@1224|Proteobacteria,1SCBX@1236|Gammaproteobacteria 1236|Gammaproteobacteria S protein conserved in bacteria ypeB - - ko:K09954 - - - - ko00000 - - - QSregVF_b k59_1520505_1 983544.Lacal_0477 2e-81 270.0 COG3291@1|root,COG4886@1|root,COG3291@2|Bacteria,COG4886@2|Bacteria,4NI4A@976|Bacteroidetes,1I0P7@117743|Flavobacteriia 976|Bacteroidetes O Fibronectin, type III domain - - - - - - - - - - - - Cleaved_Adhesin,MAM,PKD,fn3 k59_1178970_1 713587.THITH_09180 1.57e-93 288.0 COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,1RPWS@1236|Gammaproteobacteria,1WWTW@135613|Chromatiales 135613|Chromatiales S ABC transporter - - - - - - - - - - - - ABC_tran,ABC_tran_Xtn k59_779713_1 305900.GV64_03270 9.29e-76 232.0 COG0500@1|root,COG2226@2|Bacteria,1MVSY@1224|Proteobacteria,1S24V@1236|Gammaproteobacteria,1XJBT@135619|Oceanospirillales 135619|Oceanospirillales Q Methionine biosynthesis protein MetW metW - - - - - - - - - - - MetW k59_1795459_1 999550.KI421507_gene1809 4.46e-49 174.0 COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,2TR3X@28211|Alphaproteobacteria 28211|Alphaproteobacteria S COG0488 ATPase components of ABC transporters with duplicated ATPase domains uup GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0008150,GO:0009314,GO:0009628,GO:0010528,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019219,GO:0019222,GO:0031323,GO:0044424,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051171,GO:0060255,GO:0065007,GO:0070894,GO:0071944,GO:0080090,GO:0097159,GO:1901363 - ko:K15738 - - - - ko00000,ko02000 3.A.1.120.6 - - ABC_tran,ABC_tran_CTD k59_161402_1 316407.85674543 2.48e-127 377.0 COG0366@1|root,COG0366@2|Bacteria,1MVKX@1224|Proteobacteria,1RQHM@1236|Gammaproteobacteria,3XMY7@561|Escherichia 1236|Gammaproteobacteria G May play a role in regulating the intracellular level of maltotriose. Cleaves glucose from the reducing end of maltotriose and longer maltodextrins with a chain length of up to 7 glucose units malZ GO:0000272,GO:0003674,GO:0003824,GO:0004553,GO:0004558,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0005976,GO:0006073,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009251,GO:0009311,GO:0009313,GO:0009987,GO:0015926,GO:0016052,GO:0016787,GO:0016798,GO:0030978,GO:0030980,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044247,GO:0044248,GO:0044260,GO:0044262,GO:0044264,GO:0044275,GO:0044424,GO:0044464,GO:0051691,GO:0051692,GO:0071704,GO:0090599,GO:1901575 3.2.1.135,3.2.1.20 ko:K01187,ko:K21575 ko00052,ko00500,ko01100,map00052,map00500,map01100 - R00028,R00801,R00802,R06087,R06088 RC00028,RC00049,RC00077 ko00000,ko00001,ko01000 - GH13,GH31 iECH74115_1262.ECH74115_0480,iEcSMS35_1347.EcSMS35_0434,iSFV_1184.SFV_0368,iYL1228.KPN_00344 Alpha-amylase,Alpha-amylase_N,Malt_amylase_C k59_1345626_1 1121121.KB894307_gene2049 2.26e-12 68.2 COG5379@1|root,COG5379@2|Bacteria,1V1UP@1239|Firmicutes,4HX2Z@91061|Bacilli 91061|Bacilli I Protein of unknown function (DUF3419) - - - ko:K13622 ko00564,map00564 - R09072 RC00021,RC01091 ko00000,ko00001 - - - DUF3419 k59_1345626_2 1173028.ANKO01000112_gene4787 1.21e-26 108.0 COG0574@1|root,COG3848@1|root,COG0574@2|Bacteria,COG3848@2|Bacteria,1GBMT@1117|Cyanobacteria,1HE9H@1150|Oscillatoriales 1117|Cyanobacteria GT Pyruvate phosphate dikinase, PEP/pyruvate binding domain - - 2.7.9.2 ko:K01007 ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200 M00173,M00374 R00199 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - PEP-utilizers,PPDK_N k59_1408275_1 314262.MED193_13842 3.53e-21 87.0 COG2832@1|root,COG2832@2|Bacteria,1N7BI@1224|Proteobacteria,2UFAC@28211|Alphaproteobacteria,2P4WU@2433|Roseobacter 28211|Alphaproteobacteria S protein conserved in bacteria ybaN - - ko:K09790 - - - - ko00000 - - - DUF454 k59_1408276_1 1266908.AQPB01000016_gene126 1.52e-62 200.0 COG0384@1|root,COG0384@2|Bacteria,1R9X4@1224|Proteobacteria,1RZ0R@1236|Gammaproteobacteria,1X0QK@135613|Chromatiales 135613|Chromatiales S Phenazine biosynthesis-like protein - - - - - - - - - - - - PhzC-PhzF k59_1408276_2 566466.NOR53_1812 1.06e-18 81.6 COG2109@1|root,COG2109@2|Bacteria,1MUN6@1224|Proteobacteria,1RMH9@1236|Gammaproteobacteria,1J7K9@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids cobO - 2.5.1.17 ko:K19221 ko00860,ko01100,map00860,map01100 M00122 R01492,R05220,R07268 RC00533 ko00000,ko00001,ko00002,ko01000 - - - Co_AT_N,CobA_CobO_BtuR k59_334153_1 371731.Rsw2DRAFT_0559 1.06e-18 84.3 COG0454@1|root,COG0456@2|Bacteria,1RIE6@1224|Proteobacteria,2UF5C@28211|Alphaproteobacteria,1FBZP@1060|Rhodobacter 28211|Alphaproteobacteria K This enzyme acetylates the N-terminal alanine of ribosomal protein S18 rimI - 2.3.1.128 ko:K03789 - - - - ko00000,ko01000,ko03009 - - - Acetyltransf_1,Acetyltransf_10 k59_1630830_1 517722.AEUE01000001_gene2423 2.34e-103 304.0 COG2086@1|root,COG2086@2|Bacteria,1MVH6@1224|Proteobacteria,2TR4J@28211|Alphaproteobacteria,2K0GH@204457|Sphingomonadales 204457|Sphingomonadales C Electron transfer flavoprotein - - - ko:K03521 - - - - ko00000 - - - ETF k59_50921_1 688245.CtCNB1_2582 3.22e-106 322.0 COG4584@1|root,COG4584@2|Bacteria,1MWIV@1224|Proteobacteria,2VH6U@28216|Betaproteobacteria,4ABAZ@80864|Comamonadaceae 28216|Betaproteobacteria L PFAM Integrase catalytic - - - - - - - - - - - - HTH_23,HTH_24,rve k59_276624_1 1004785.AMBLS11_17585 2.47e-32 121.0 COG0730@1|root,COG0730@2|Bacteria,1RAG9@1224|Proteobacteria,1S2RX@1236|Gammaproteobacteria,466JN@72275|Alteromonadaceae 1236|Gammaproteobacteria S membrane transporter protein - - - - - - - - - - - - TauE k59_276624_2 1215092.PA6_044_00100 1.01e-10 62.0 COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,1RV50@1236|Gammaproteobacteria,1YD82@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria I Belongs to the thiolase family fadA - 2.3.1.16,2.3.1.9 ko:K00626,ko:K00632 ko00071,ko00072,ko00280,ko00281,ko00310,ko00362,ko00380,ko00592,ko00620,ko00630,ko00640,ko00642,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00281,map00310,map00362,map00380,map00592,map00620,map00630,map00640,map00642,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00087,M00088,M00095,M00113,M00373,M00374,M00375 R00238,R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095 RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N k59_1120105_1 1168065.DOK_03528 1.6e-19 89.0 COG1752@1|root,COG1752@2|Bacteria,1N5SK@1224|Proteobacteria,1RSDG@1236|Gammaproteobacteria,1J8T7@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S esterase of the alpha-beta hydrolase superfamily - - - - - - - - - - - - DUF3336,Patatin k59_50929_1 1112209.AHVZ01000017_gene743 1e-53 175.0 COG1949@1|root,COG1949@2|Bacteria,1R9WX@1224|Proteobacteria,1S217@1236|Gammaproteobacteria,3NIIC@468|Moraxellaceae 1236|Gammaproteobacteria A 3'-to-5' exoribonuclease specific for small oligoribonucleotides orn GO:0000175,GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004529,GO:0004532,GO:0004536,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008296,GO:0008297,GO:0008310,GO:0008408,GO:0008946,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0016896,GO:0019439,GO:0034611,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0140097,GO:0140098,GO:1901360,GO:1901361,GO:1901575 - ko:K13288 ko03008,map03008 - - - ko00000,ko00001,ko01000,ko03009,ko03019 - - - RNase_T k59_50929_2 1163617.SCD_n02414 2.15e-48 162.0 COG0500@1|root,COG0500@2|Bacteria,1RDHE@1224|Proteobacteria,2VQIP@28216|Betaproteobacteria 28216|Betaproteobacteria Q Protein of unknown function (DUF938) - - - - - - - - - - - - DUF938 k59_1578173_1 1173024.KI912148_gene3523 6.06e-98 298.0 COG2403@1|root,COG2403@2|Bacteria,1G1FF@1117|Cyanobacteria 1117|Cyanobacteria S cyclic 2,3-diphosphoglycerate synthetase activity - - - - - - - - - - - - cobW k59_1459112_1 102129.Lepto7375DRAFT_0929 3.3e-114 338.0 COG3039@1|root,COG3039@2|Bacteria,1G5XM@1117|Cyanobacteria 1117|Cyanobacteria L Transposase - - - - - - - - - - - - - k59_107004_1 1088721.NSU_1531 3.76e-126 379.0 COG3975@1|root,COG3975@2|Bacteria,1MUHZ@1224|Proteobacteria,2TRZF@28211|Alphaproteobacteria,2K0CU@204457|Sphingomonadales 204457|Sphingomonadales S protease with the C-terminal PDZ - - - - - - - - - - - - Peptidase_M61 k59_107005_1 220341.16505508 3.86e-134 391.0 COG3037@1|root,COG3037@2|Bacteria,1MWNR@1224|Proteobacteria,1RP9S@1236|Gammaproteobacteria,3ZJH9@590|Salmonella 1236|Gammaproteobacteria U PTS system sugar-specific permease component ulaA GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008643,GO:0009401,GO:0015144,GO:0015711,GO:0015749,GO:0015849,GO:0015882,GO:0016020,GO:0016740,GO:0016772,GO:0016773,GO:0022804,GO:0022857,GO:0034219,GO:0034220,GO:0035461,GO:0042802,GO:0044464,GO:0046942,GO:0051179,GO:0051180,GO:0051181,GO:0051182,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0090563,GO:0090585,GO:0098656,GO:1903825,GO:1905039 2.7.1.194 ko:K02822,ko:K03475 ko00053,ko01100,ko01120,ko02060,map00053,map01100,map01120,map02060 M00283,M00550 R07671 RC00017,RC03206 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.7.1 - iB21_1397.B21_04022,iEC55989_1330.EC55989_4750,iECBD_1354.ECBD_3841,iECB_1328.ECB_04060,iECD_1391.ECD_04060,iECIAI1_1343.ECIAI1_4426,iECO111_1330.ECO111_5021,iETEC_1333.ETEC_4539,iEcSMS35_1347.EcSMS35_4664 EIIC-GAT,PTS_IIB k59_1630867_1 930166.CD58_10740 9.52e-52 164.0 COG0776@1|root,COG0776@2|Bacteria,1RH5Z@1224|Proteobacteria,1S61Z@1236|Gammaproteobacteria 1236|Gammaproteobacteria K This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control himA GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0032774,GO:0032991,GO:0032993,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043565,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0046483,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2001141 - ko:K04764 - - - - ko00000,ko03032,ko03036,ko03400 - - - Bac_DNA_binding k59_1630867_2 1026882.MAMP_02692 7.03e-15 68.9 COG0789@1|root,COG0789@2|Bacteria,1RGYB@1224|Proteobacteria,1S6Y1@1236|Gammaproteobacteria,460TM@72273|Thiotrichales 72273|Thiotrichales K PFAM MerR family regulatory protein - - - - - - - - - - - - MerR_1 k59_553302_1 1229909.NSED_04040 5.15e-127 369.0 COG1060@1|root,arCOG00656@2157|Archaea,41SEG@651137|Thaumarchaeota 651137|Thaumarchaeota H Radical SAM - - 2.5.1.120 ko:K18285 ko00130,ko01110,map00130,map01110 - R10667 RC00021,RC03234 ko00000,ko00001,ko01000 - - - Radical_SAM k59_1743206_1 1142394.PSMK_03130 9.96e-64 209.0 COG0304@1|root,COG0304@2|Bacteria,2IY1N@203682|Planctomycetes 203682|Planctomycetes IQ Belongs to the beta-ketoacyl-ACP synthases family - - 2.3.1.179 ko:K09458 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119 RC00039,RC02728,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Ketoacyl-synt_C,ketoacyl-synt k59_950416_1 580332.Slit_1269 1.15e-47 165.0 COG2114@1|root,COG2114@2|Bacteria,1RD0X@1224|Proteobacteria,2VS0D@28216|Betaproteobacteria,44VWF@713636|Nitrosomonadales 28216|Betaproteobacteria T adenylyl cyclase class-3 4 guanylyl cyclase - - - - - - - - - - - - Guanylate_cyc,PEGA k59_950416_2 580332.Slit_2544 1.81e-07 51.6 COG0073@1|root,COG0143@1|root,COG0073@2|Bacteria,COG0143@2|Bacteria,1MUBY@1224|Proteobacteria,2VH19@28216|Betaproteobacteria,44VP7@713636|Nitrosomonadales 28216|Betaproteobacteria J Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation metG - 6.1.1.10 ko:K01874 ko00450,ko00970,map00450,map00970 M00359,M00360 R03659,R04773 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,tRNA-synt_1g,tRNA_bind k59_334252_1 1121013.P873_00390 2.76e-77 238.0 COG1842@1|root,COG1842@2|Bacteria,1NNUD@1224|Proteobacteria 1224|Proteobacteria KT PspA/IM30 family - - - ko:K03969 - - - - ko00000 - - - PspA_IM30 k59_1241186_1 1278307.KB907057_gene2644 2.22e-44 157.0 COG3547@1|root,COG3547@2|Bacteria,1NGR7@1224|Proteobacteria,1RMF9@1236|Gammaproteobacteria,2QJ5B@267894|Psychromonadaceae 1236|Gammaproteobacteria L COG3547 Transposase and inactivated derivatives - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_787599_1 1177181.T9A_01712 0.000104 50.8 COG0607@1|root,COG0664@1|root,COG0607@2|Bacteria,COG0664@2|Bacteria,1R9Q1@1224|Proteobacteria,1RSKD@1236|Gammaproteobacteria,1XQZT@135619|Oceanospirillales 135619|Oceanospirillales PT COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases - - - - - - - - - - - - Rhodanese,cNMP_binding k59_847293_1 631454.N177_2475 1.44e-50 174.0 COG0477@1|root,COG2814@2|Bacteria 2|Bacteria EGP Major facilitator Superfamily - - - - - - - - - - - - MFS_1 k59_1694152_1 1122137.AQXF01000001_gene2965 1.69e-220 613.0 COG0192@1|root,COG0192@2|Bacteria,1MUFQ@1224|Proteobacteria,2TR4P@28211|Alphaproteobacteria 28211|Alphaproteobacteria H Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme metK - 2.5.1.6 ko:K00789 ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230 M00034,M00035,M00368,M00609 R00177,R04771 RC00021,RC01211 ko00000,ko00001,ko00002,ko01000 - - - S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N k59_1694152_2 1122137.AQXF01000001_gene2963 1.02e-40 151.0 COG0642@1|root,COG2205@2|Bacteria,1MVY8@1224|Proteobacteria,2TS5B@28211|Alphaproteobacteria 28211|Alphaproteobacteria T Histidine kinase divL GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - - - - - - - - - - HATPase_c,HisKA,PAS_7,PAS_8 k59_450124_1 1122137.AQXF01000004_gene1829 1.77e-187 525.0 COG0208@1|root,COG0208@2|Bacteria,1MWUS@1224|Proteobacteria,2TS3X@28211|Alphaproteobacteria 28211|Alphaproteobacteria F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides nrdF - 1.17.4.1 ko:K00526 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - Ribonuc_red_sm k59_450128_1 1219035.NT2_05_02220 4.71e-14 74.3 COG4774@1|root,COG4774@2|Bacteria,1NMCN@1224|Proteobacteria,2VFNP@28211|Alphaproteobacteria,2KDY2@204457|Sphingomonadales 204457|Sphingomonadales P TonB dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_561219_1 1122137.AQXF01000001_gene3209 3.4e-71 219.0 COG1595@1|root,COG1595@2|Bacteria,1MX7T@1224|Proteobacteria,2U5A1@28211|Alphaproteobacteria 28211|Alphaproteobacteria K Belongs to the sigma-70 factor family. ECF subfamily sigW - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 k59_1694167_1 288000.BBta_7802 7.08e-43 157.0 COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,2TRNK@28211|Alphaproteobacteria,3JVXA@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins - - - ko:K03798 - M00742 - - ko00000,ko00002,ko01000,ko01002,ko03110 - - - AAA,FtsH_ext,Peptidase_M41 k59_1128246_1 498211.CJA_3550 6.34e-51 174.0 COG2861@1|root,COG2861@2|Bacteria,1N3JP@1224|Proteobacteria,1RNKH@1236|Gammaproteobacteria,1FGW6@10|Cellvibrio 1236|Gammaproteobacteria S Divergent polysaccharide deacetylase yibQ - - ko:K09798 - - - - ko00000 - - - Polysacc_deac_2 k59_1128246_2 8932.XP_005511046.1 5.11e-05 45.8 KOG3649@1|root,KOG3649@2759|Eukaryota,3ACKQ@33154|Opisthokonta,3BVR9@33208|Metazoa,3DC5I@33213|Bilateria,48G6R@7711|Chordata,49D68@7742|Vertebrata,4GVRB@8782|Aves 33208|Metazoa S Serine protease inhibitor Kazal-type 2 SPINK2 GO:0001669,GO:0003674,GO:0004857,GO:0004866,GO:0004867,GO:0005575,GO:0005576,GO:0005615,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009892,GO:0010466,GO:0010605,GO:0010951,GO:0012505,GO:0019222,GO:0030141,GO:0030162,GO:0030234,GO:0030414,GO:0031323,GO:0031324,GO:0031410,GO:0031982,GO:0032268,GO:0032269,GO:0043086,GO:0043226,GO:0043227,GO:0043229,GO:0043900,GO:0044092,GO:0044421,GO:0044424,GO:0044444,GO:0044464,GO:0045861,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0051336,GO:0051346,GO:0052547,GO:0052548,GO:0060046,GO:0060255,GO:0061134,GO:0061135,GO:0065007,GO:0065009,GO:0080090,GO:0080154,GO:0097223,GO:0097708,GO:0098772,GO:0099503,GO:1900003,GO:1900004,GO:1902571,GO:1902572,GO:2000241 - - - - - - - - - - Kazal_1 k59_1694180_1 1229909.NSED_08915 2.13e-98 303.0 arCOG08793@1|root,arCOG08812@1|root,arCOG08793@2157|Archaea,arCOG08812@2157|Archaea,41T0K@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_847341_1 935848.JAEN01000011_gene1910 8.75e-74 231.0 COG0117@1|root,COG1985@1|root,COG0117@2|Bacteria,COG1985@2|Bacteria,1MUWT@1224|Proteobacteria,2TR70@28211|Alphaproteobacteria,2PUI8@265|Paracoccus 28211|Alphaproteobacteria H Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate ribD - 1.1.1.193,3.5.4.26 ko:K11752 ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024 M00125 R03458,R03459 RC00204,RC00933 ko00000,ko00001,ko00002,ko01000 - - - RibD_C,dCMP_cyt_deam_1 k59_847341_2 1122137.AQXF01000002_gene64 3.29e-44 145.0 COG1327@1|root,COG1327@2|Bacteria,1RE7V@1224|Proteobacteria,2U75W@28211|Alphaproteobacteria 28211|Alphaproteobacteria K Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes nrdR - - ko:K07738 - - - - ko00000,ko03000 - - - ATP-cone k59_1013667_1 443143.GM18_0341 1.81e-67 226.0 COG2133@1|root,COG2133@2|Bacteria,1NRFC@1224|Proteobacteria,42YAV@68525|delta/epsilon subdivisions,2WTUF@28221|Deltaproteobacteria 28221|Deltaproteobacteria G Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses - - - - - - - - - - - - - k59_1803462_1 436308.Nmar_0912 2.39e-106 309.0 COG0512@1|root,arCOG00086@2157|Archaea,41SGV@651137|Thaumarchaeota 651137|Thaumarchaeota E Glutamine amidotransferase of anthranilate synthase - - 4.1.3.27 ko:K01658 ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025 M00023 R00985,R00986 RC00010,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 - - - GATase k59_1297353_2 1122137.AQXF01000002_gene366 1.99e-131 379.0 COG3000@1|root,COG3000@2|Bacteria,1NR7X@1224|Proteobacteria,2TT68@28211|Alphaproteobacteria 28211|Alphaproteobacteria I COG3000 Sterol desaturase - - - - - - - - - - - - FA_hydroxylase k59_847346_1 1144275.COCOR_05114 1.77e-53 178.0 COG2230@1|root,COG2230@2|Bacteria,1MX3U@1224|Proteobacteria,42PB7@68525|delta/epsilon subdivisions,2WJX5@28221|Deltaproteobacteria,2Z1H2@29|Myxococcales 28221|Deltaproteobacteria M Mycolic acid cyclopropane synthetase cfa1 - 2.1.1.317,2.1.1.79 ko:K00574,ko:K20238 - - - - ko00000,ko01000 - - iAF987.Gmet_2187 CMAS k59_450182_1 1463895.JODA01000034_gene3232 6.1e-24 99.8 COG2353@1|root,COG2353@2|Bacteria,2GJUB@201174|Actinobacteria 201174|Actinobacteria S Belongs to the UPF0312 family yceI - - - - - - - - - - - YceI k59_561259_1 266117.Rxyl_0156 3.91e-29 120.0 COG3845@1|root,COG3845@2|Bacteria,2H7KJ@201174|Actinobacteria,4CPFE@84995|Rubrobacteria 84995|Rubrobacteria S PFAM ABC transporter related - - 3.6.3.17 ko:K02056 - M00221 - - ko00000,ko00002,ko01000,ko02000 3.A.1.2 - - ABC_tran k59_169182_1 1469245.JFBG01000072_gene72 2.28e-42 148.0 COG0278@1|root,COG0316@1|root,COG0607@1|root,COG0278@2|Bacteria,COG0316@2|Bacteria,COG0607@2|Bacteria,1MZ4V@1224|Proteobacteria,1SKDF@1236|Gammaproteobacteria 1236|Gammaproteobacteria OP Glutaredoxin - - - ko:K07390 - - - - ko00000,ko03029,ko03110 - - - Glutaredoxin,Rhodanese k59_169182_2 502025.Hoch_4835 1.7e-17 85.5 COG1199@1|root,COG1199@2|Bacteria,1MVRJ@1224|Proteobacteria,42NV8@68525|delta/epsilon subdivisions,2WJIW@28221|Deltaproteobacteria 28221|Deltaproteobacteria L DEAD_2 - - 3.6.4.12 ko:K10844 ko03022,ko03420,map03022,map03420 M00290 - - ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - DEAD,DEAD_2,Helicase_C_2 k59_505367_2 598659.NAMH_0320 1.71e-121 368.0 COG0056@1|root,COG0056@2|Bacteria,1MUG7@1224|Proteobacteria,42MVX@68525|delta/epsilon subdivisions,2YMSF@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit atpA - 3.6.3.14 ko:K02111 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - iIT341.HP1134 ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N k59_505370_1 436308.Nmar_1313 3.64e-31 112.0 COG0640@1|root,arCOG00731@2157|Archaea 2157|Archaea K regulatory protein, arsR - - - - - - - - - - - - HTH_5 k59_505370_2 1229909.NSED_07270 1.12e-48 166.0 COG0334@1|root,arCOG01352@2157|Archaea,41S7T@651137|Thaumarchaeota 651137|Thaumarchaeota E Belongs to the Glu Leu Phe Val dehydrogenases family - - 1.4.1.3 ko:K00261 ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964 M00740 R00243,R00248 RC00006,RC02799 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ELFV_dehydrog,ELFV_dehydrog_N k59_1353477_1 1521187.JPIM01000030_gene1503 1.09e-10 68.6 COG2203@1|root,COG5002@1|root,COG2203@2|Bacteria,COG5002@2|Bacteria,2G7NF@200795|Chloroflexi,374TJ@32061|Chloroflexia 32061|Chloroflexia T histidine kinase A domain protein - - - - - - - - - - - - GAF,GAF_2,HATPase_c,HisKA,PAS k59_1750959_1 1229909.NSED_03230 6.95e-126 371.0 arCOG08742@1|root,arCOG08742@2157|Archaea,41SS8@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_847367_1 717785.HYPMC_1471 3.5e-65 214.0 COG0119@1|root,COG0119@2|Bacteria,1MUNQ@1224|Proteobacteria,2TSCJ@28211|Alphaproteobacteria,3N660@45401|Hyphomicrobiaceae 28211|Alphaproteobacteria E Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) leuA - 2.3.3.13 ko:K01649 ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230 M00432 R01213 RC00004,RC00470,RC02754 br01601,ko00000,ko00001,ko00002,ko01000 - - - HMGL-like,LeuA_dimer k59_1128276_1 368407.Memar_1510 1.78e-131 387.0 COG2133@1|root,arCOG02796@2157|Archaea 2157|Archaea G COG2133 Glucose sorbosone dehydrogenases - - - - - - - - - - - - GSDH k59_1803503_1 47839.CCAU010000001_gene3051 3.68e-51 177.0 COG2015@1|root,COG2015@2|Bacteria,2H3T3@201174|Actinobacteria,235UZ@1762|Mycobacteriaceae 201174|Actinobacteria Q Metallo-beta-lactamase superfamily - - - - - - - - - - - - Alkyl_sulf_dimr,Lactamase_B k59_1803503_2 398579.Spea_1607 5.58e-19 80.1 COG3631@1|root,COG3631@2|Bacteria,1RJ29@1224|Proteobacteria,1S6S3@1236|Gammaproteobacteria,2QC9V@267890|Shewanellaceae 1236|Gammaproteobacteria S SnoaL-like domain - - - - - - - - - - - - SnoaL_2 k59_958387_1 1131813.AQVT01000001_gene2423 3.74e-13 75.1 COG0643@1|root,COG0745@1|root,COG0643@2|Bacteria,COG0745@2|Bacteria,1MUAG@1224|Proteobacteria,2TSN2@28211|Alphaproteobacteria,1JT0D@119045|Methylobacteriaceae 28211|Alphaproteobacteria T ATP-binding region ATPase domain protein - - 2.7.13.3 ko:K03407,ko:K13490 ko02020,ko02025,ko02030,map02020,map02025,map02030 M00506,M00509 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 - - - CheW,HATPase_c,Hpt,Response_reg k59_505381_1 266779.Meso_0340 2.07e-146 441.0 COG0642@1|root,COG0784@1|root,COG4192@1|root,COG0784@2|Bacteria,COG2205@2|Bacteria,COG4192@2|Bacteria,1MUY7@1224|Proteobacteria,2TR1M@28211|Alphaproteobacteria 28211|Alphaproteobacteria T Histidine kinase - - - - - - - - - - - - HATPase_c,HisKA,PAS_4,PAS_7,Response_reg,dCache_1 k59_1128288_1 1268068.PG5_49130 6.85e-14 70.9 COG0625@1|root,COG0625@2|Bacteria,1RA4M@1224|Proteobacteria,1S2K3@1236|Gammaproteobacteria 1236|Gammaproteobacteria O Glutathione S-Transferase yliJ GO:0003674,GO:0003824,GO:0004364,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0016491,GO:0016740,GO:0016765,GO:0030611,GO:0042802,GO:0044424,GO:0044444,GO:0044464,GO:0055114 2.5.1.18 ko:K00799 ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418 - R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905 RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944 ko00000,ko00001,ko01000,ko02000 1.A.12.2.2,1.A.12.3.2 - - GST_C,GST_C_2,GST_N,GST_N_3 k59_169223_1 1254432.SCE1572_31580 4.49e-21 95.9 COG2706@1|root,COG2706@2|Bacteria,1MWTE@1224|Proteobacteria 1224|Proteobacteria G 6-phosphogluconolactonase activity - - - - - - - - - - - - Lactonase k59_561311_1 402881.Plav_1622 4.11e-61 200.0 COG0208@1|root,COG0208@2|Bacteria,1R4T3@1224|Proteobacteria,2U55H@28211|Alphaproteobacteria 28211|Alphaproteobacteria F P-aminobenzoate N-oxygenase AurF - - - - - - - - - - - - AurF k59_505413_1 744980.TRICHSKD4_1069 6.78e-49 166.0 COG0582@1|root,COG0582@2|Bacteria,1NH8M@1224|Proteobacteria,2TUHG@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Belongs to the 'phage' integrase family int - - - - - - - - - - - Phage_integrase k59_1128315_1 1173264.KI913949_gene1409 1.69e-11 63.5 COG0330@1|root,COG0330@2|Bacteria 2|Bacteria O stress-induced mitochondrial fusion cnpD - - - - - - - - - - - Band_7 k59_1128315_2 443143.GM18_3859 1.38e-72 228.0 COG0061@1|root,COG0061@2|Bacteria,1NBI3@1224|Proteobacteria,42ZTT@68525|delta/epsilon subdivisions,2WV8A@28221|Deltaproteobacteria 28221|Deltaproteobacteria G Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP - - - - - - - - - - - - - k59_1242944_1 518766.Rmar_2590 1.64e-128 379.0 COG3259@1|root,COG3259@2|Bacteria 2|Bacteria C Nickel-dependent hydrogenase hoxH - 1.12.1.2 ko:K00436 - - R00700 - ko00000,ko01000 - - - NiFeSe_Hases k59_1353579_1 290317.Cpha266_1211 8.72e-05 45.4 COG4453@1|root,COG4453@2|Bacteria 2|Bacteria K Protein conserved in bacteria VY92_07520 - - - - - - - - - - - DUF1778 k59_1353579_2 113355.CM001775_gene1412 1.98e-27 107.0 COG3153@1|root,COG3153@2|Bacteria,1GHM5@1117|Cyanobacteria 1117|Cyanobacteria S Acetyltransferase (GNAT) family - - - - - - - - - - - - Acetyltransf_1,Acetyltransf_7 k59_1353579_3 314254.OA2633_03791 3.88e-09 62.0 COG3209@1|root,COG3209@2|Bacteria,1MVV1@1224|Proteobacteria,2U4RY@28211|Alphaproteobacteria,43YWV@69657|Hyphomonadaceae 28211|Alphaproteobacteria M TIGRFAM RHS repeat-associated core domain-containing protein, YD repeat protein - - - - - - - - - - - - RHS_repeat,SpvB,TcdB_toxin_midN k59_787788_1 2342.SOPEG_3120 8.51e-09 55.8 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria 1236|Gammaproteobacteria T COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains yfhA GO:0000156,GO:0000160,GO:0000976,GO:0000984,GO:0001017,GO:0001067,GO:0001130,GO:0001150,GO:0001151,GO:0001158,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0023052,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0035326,GO:0035556,GO:0043170,GO:0043565,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0045893,GO:0045935,GO:0046483,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051716,GO:0060089,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2001141 - ko:K07715 ko02020,ko02024,map02020,map02024 M00502 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_787788_2 498211.CJA_3399 3.71e-52 179.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,1FFRG@10|Cellvibrio 1236|Gammaproteobacteria T Bacterial regulatory protein, Fis family prsR - - ko:K02481 - - - - ko00000,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_1297534_1 1122137.AQXF01000003_gene2401 7.05e-71 220.0 COG3153@1|root,COG3153@2|Bacteria,1RD0C@1224|Proteobacteria,2U7AS@28211|Alphaproteobacteria 28211|Alphaproteobacteria S -acetyltransferase - - - - - - - - - - - - Acetyltransf_1,Acetyltransf_9 k59_958515_1 985665.HPL003_17955 3.42e-19 87.0 COG1028@1|root,COG1028@2|Bacteria,1TP76@1239|Firmicutes,4HAA6@91061|Bacilli,26QK6@186822|Paenibacillaceae 91061|Bacilli IQ reductase fabG GO:0000166,GO:0003674,GO:0003824,GO:0004312,GO:0004316,GO:0005488,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0030497,GO:0032787,GO:0036094,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0072330,GO:0097159,GO:1901265,GO:1901363,GO:1901576 1.1.1.100 ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - iYO844.BSU15910 adh_short_C2 k59_1013806_1 1122137.AQXF01000003_gene1995 4.84e-123 379.0 COG0612@1|root,COG0612@2|Bacteria,1MVST@1224|Proteobacteria,2TRFB@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Belongs to the peptidase M16 family - - - ko:K07263 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M16,Peptidase_M16_C k59_676463_1 391603.FBALC1_15292 1.13e-91 290.0 COG3525@1|root,COG3525@2|Bacteria,4NE08@976|Bacteroidetes,1HXU1@117743|Flavobacteriia 976|Bacteroidetes G Glycosyl hydrolase family 20, catalytic domain - - 3.2.1.52 ko:K12373 ko00511,ko00513,ko00520,ko00531,ko00603,ko00604,ko01100,ko04142,map00511,map00513,map00520,map00531,map00603,map00604,map01100,map04142 M00079 R00022,R06004,R11316 RC00049 ko00000,ko00001,ko00002,ko01000,ko03110 - GH20 - CHB_HEX_C_1,F5_F8_type_C,Fn3_assoc,Glyco_hydro_20,Glyco_hydro_20b k59_676463_2 319236.JCM19294_928 2.93e-05 45.1 COG3142@1|root,COG3142@2|Bacteria,4NINY@976|Bacteroidetes,1I1FE@117743|Flavobacteriia,3HK65@363408|Nonlabens 976|Bacteroidetes P Participates in the control of copper homeostasis cutC - - ko:K06201 - - - - ko00000 - - - CutC k59_1694344_1 1005048.CFU_3531 2.24e-77 244.0 COG2079@1|root,COG2079@2|Bacteria,1MUIG@1224|Proteobacteria,2VH7T@28216|Betaproteobacteria,4738R@75682|Oxalobacteraceae 28216|Betaproteobacteria S MmgE/PrpD family prpD - 4.2.1.79 ko:K01720 ko00640,map00640 - R04424 RC01152 ko00000,ko00001,ko01000 - - - MmgE_PrpD k59_1694344_2 305700.B447_02066 3.12e-09 54.7 2EPEP@1|root,3333Z@2|Bacteria,1NCEZ@1224|Proteobacteria,2VXCQ@28216|Betaproteobacteria,2KXP9@206389|Rhodocyclales 206389|Rhodocyclales S Protein of unknown function (DUF3460) - - - - - - - - - - - - DUF3460 k59_1694344_3 1415779.JOMH01000001_gene628 3.76e-16 76.6 COG0372@1|root,COG0372@2|Bacteria,1MUKX@1224|Proteobacteria,1RNT1@1236|Gammaproteobacteria,1X397@135614|Xanthomonadales 135614|Xanthomonadales C also catalyzes the condensation of oxaloacetate with acetyl-CoA but with a lower specificity prpC - 2.3.3.5 ko:K01659 ko00640,map00640 - R00931 RC00004,RC00406,RC02827 ko00000,ko00001,ko01000 - - - Citrate_synt k59_676477_1 702113.PP1Y_AT28954 7.01e-59 204.0 COG3264@1|root,COG3264@2|Bacteria,1MWSA@1224|Proteobacteria,2TRKK@28211|Alphaproteobacteria,2K0A6@204457|Sphingomonadales 204457|Sphingomonadales M mechanosensitive ion channel - - - ko:K05802 - - - - ko00000,ko02000 1.A.23.1.1 - - MS_channel k59_1751082_1 203122.Sde_2809 1.22e-113 349.0 COG3507@1|root,COG3507@2|Bacteria,1R4H2@1224|Proteobacteria,1SXV5@1236|Gammaproteobacteria,469KM@72275|Alteromonadaceae 1236|Gammaproteobacteria G Ricin-type beta-trefoil - - 3.2.1.99 ko:K06113 - - - - ko00000,ko01000 - GH43 - RicinB_lectin_2 k59_450332_2 383381.EH30_00855 3.32e-08 57.0 COG0153@1|root,COG0153@2|Bacteria,1MVQD@1224|Proteobacteria,2U2RP@28211|Alphaproteobacteria,2K8ZB@204457|Sphingomonadales 204457|Sphingomonadales G Belongs to the GHMP kinase family. GalK subfamily - - 2.7.1.6 ko:K00849 ko00052,ko00520,ko01100,map00052,map00520,map01100 M00554,M00632 R01092 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000,ko04147 - - - GHMP_kinases_C,GHMP_kinases_N,GalKase_gal_bdg k59_1013845_1 342610.Patl_1723 4.84e-84 275.0 COG1629@1|root,COG1629@2|Bacteria,COG4771@2|Bacteria,1MUNK@1224|Proteobacteria,1RN9S@1236|Gammaproteobacteria,2Q0D4@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria P COG1629 Outer membrane receptor proteins, mostly Fe transport - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_1694373_2 1411685.U062_00300 3.02e-46 160.0 COG3146@1|root,COG3146@2|Bacteria,1MU35@1224|Proteobacteria,1RNWI@1236|Gammaproteobacteria,1J4M8@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S protein conserved in bacteria - - - ko:K09919 - - - - ko00000 - - - FemAB_like k59_561520_1 1396141.BATP01000035_gene4106 1.03e-67 229.0 COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,46UAE@74201|Verrucomicrobia,2IV44@203494|Verrucomicrobiae 203494|Verrucomicrobiae KLT Protein tyrosine kinase - - - - - - - - - - - - Pkinase,TPR_12,WD40 k59_561528_1 1096930.L284_10395 5.99e-80 238.0 COG0652@1|root,COG0652@2|Bacteria,1R9ZQ@1224|Proteobacteria,2U591@28211|Alphaproteobacteria,2K3YQ@204457|Sphingomonadales 204457|Sphingomonadales O PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides - - 5.2.1.8 ko:K01802 - - - - ko00000,ko01000 - - - Pro_isomerase k59_1751120_1 335283.Neut_1794 2.39e-12 72.0 COG0086@1|root,COG0086@2|Bacteria,1MU3M@1224|Proteobacteria,2VIF3@28216|Betaproteobacteria,371R1@32003|Nitrosomonadales 28216|Betaproteobacteria K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoC - 2.7.7.6 ko:K03046 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5 k59_1128505_1 1042375.AFPL01000052_gene382 1.03e-36 140.0 COG0617@1|root,COG0617@2|Bacteria,1MVCS@1224|Proteobacteria,1RMBG@1236|Gammaproteobacteria,464KY@72275|Alteromonadaceae 1236|Gammaproteobacteria H Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control pcnB GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0004652,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006276,GO:0006378,GO:0006396,GO:0006397,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016740,GO:0016772,GO:0016779,GO:0031123,GO:0031124,GO:0034641,GO:0043170,GO:0043412,GO:0043631,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070566,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363 2.7.7.19 ko:K00970 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - PolyA_pol,PolyA_pol_RNAbd,PolyA_pol_arg_C k59_1297648_1 867900.Celly_1204 1.3e-98 290.0 COG0288@1|root,COG0288@2|Bacteria,4NH0X@976|Bacteroidetes,1HXY7@117743|Flavobacteriia,1F838@104264|Cellulophaga 976|Bacteroidetes P Reversible hydration of carbon dioxide - - 4.2.1.1 ko:K01673 ko00910,map00910 - R00132,R10092 RC02807 ko00000,ko00001,ko01000 - - - Pro_CA k59_676533_1 747365.Thena_1023 4.19e-14 73.9 COG1297@1|root,COG1297@2|Bacteria,1TQJP@1239|Firmicutes,247JY@186801|Clostridia,42F20@68295|Thermoanaerobacterales 186801|Clostridia S oligopeptide transporter, OPT family - - - - - - - - - - - - OPT k59_676533_2 99598.Cal7507_0046 2.97e-17 81.3 COG0442@1|root,COG0442@2|Bacteria,1G238@1117|Cyanobacteria,1HIIX@1161|Nostocales 1117|Cyanobacteria J Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS proS - 6.1.1.15 ko:K01881 ko00970,map00970 M00359,M00360 R03661 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iJN678.proS HGTP_anticodon,tRNA-synt_2b,tRNA_edit k59_1694407_1 1254432.SCE1572_04370 3.67e-76 246.0 COG0480@1|root,COG0480@2|Bacteria,1MUCV@1224|Proteobacteria,42NDG@68525|delta/epsilon subdivisions,2WKYU@28221|Deltaproteobacteria,2YTWT@29|Myxococcales 28221|Deltaproteobacteria J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome fusA1 - - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2 k59_450363_1 751994.AGIG01000028_gene1918 6.45e-100 300.0 COG0224@1|root,COG0224@2|Bacteria,1MU28@1224|Proteobacteria,1RNWJ@1236|Gammaproteobacteria,1J4Q3@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex atpG GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0036442,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045261,GO:0045262,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0046961,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - ko:K02115 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - iSSON_1240.SSON_3886,iYL1228.KPN_04138 ATP-synt k59_450363_2 999141.GME_10356 3.63e-78 248.0 COG0056@1|root,COG0056@2|Bacteria,1MUG7@1224|Proteobacteria,1RP4V@1236|Gammaproteobacteria,1XHRG@135619|Oceanospirillales 135619|Oceanospirillales C Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit atpA - 3.6.3.14 ko:K02111 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - - ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N k59_1694414_1 1236959.BAMT01000001_gene1272 2.2e-32 119.0 COG3040@1|root,COG3040@2|Bacteria,1RDAI@1224|Proteobacteria,2VRSU@28216|Betaproteobacteria,2KMSV@206350|Nitrosomonadales 206350|Nitrosomonadales M Lipocalin / cytosolic fatty-acid binding protein family - - - ko:K03098 - - - - ko00000,ko04147 - - - Lipocalin_2 k59_1297663_2 1288826.MSNKSG1_08598 9.07e-13 64.7 COG1666@1|root,COG1666@2|Bacteria,1RDTF@1224|Proteobacteria,1S3RU@1236|Gammaproteobacteria,466ZE@72275|Alteromonadaceae 1236|Gammaproteobacteria S Belongs to the UPF0234 family yajQ GO:0000049,GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005524,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006974,GO:0008144,GO:0008150,GO:0009987,GO:0017076,GO:0019001,GO:0030554,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032559,GO:0032561,GO:0033554,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - ko:K09767 - - - - ko00000 - - - DUF520 k59_1013897_1 1231241.Mc24_04645 4.02e-31 124.0 COG2342@1|root,COG2342@2|Bacteria,2GCU9@200918|Thermotogae 200918|Thermotogae G Cysteinyl-tRNA synthetase - - 6.1.1.16 ko:K01884 ko00970,map00970 M00360 R03650 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iLJ478.TM1410 Glyco_hydro_114 k59_561589_1 1095769.CAHF01000013_gene3344 2.69e-08 54.3 COG0413@1|root,COG0413@2|Bacteria,1MU3B@1224|Proteobacteria,2VHZ0@28216|Betaproteobacteria,4731T@75682|Oxalobacteraceae 28216|Betaproteobacteria H Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate panB - 2.1.2.11 ko:K00606 ko00770,ko01100,ko01110,map00770,map01100,map01110 M00119 R01226 RC00022,RC00200 ko00000,ko00001,ko00002,ko01000 - - - Pantoate_transf k59_561589_2 1123073.KB899241_gene1857 5.28e-58 190.0 COG0414@1|root,COG0414@2|Bacteria,1MV1S@1224|Proteobacteria,1RMEG@1236|Gammaproteobacteria,1X3FN@135614|Xanthomonadales 135614|Xanthomonadales H Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate panC GO:0003674,GO:0003824,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006573,GO:0006575,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016874,GO:0016879,GO:0016881,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901564,GO:1901566,GO:1901576,GO:1901605 6.3.2.1 ko:K01918 ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110 M00119 R02473 RC00096,RC00141 ko00000,ko00001,ko00002,ko01000 - - - Pantoate_ligase k59_1751160_1 1380356.JNIK01000016_gene3542 1.95e-72 238.0 COG0578@1|root,COG0578@2|Bacteria,2GJKN@201174|Actinobacteria,4ES07@85013|Frankiales 201174|Actinobacteria C Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family - - 1.1.5.3 ko:K00111 ko00564,ko01110,map00564,map01110 - R00848 RC00029 ko00000,ko00001,ko01000 - - - DAO,DAO_C k59_798415_1 1123023.JIAI01000007_gene1886 8.86e-145 424.0 COG1960@1|root,COG1960@2|Bacteria,2HEKC@201174|Actinobacteria,4DZQY@85010|Pseudonocardiales 201174|Actinobacteria I acyl-CoA dehydrogenase - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_798415_2 1283283.ATXA01000014_gene3561 4.02e-51 179.0 COG1960@1|root,COG1960@2|Bacteria,2GKVN@201174|Actinobacteria 201174|Actinobacteria I acyl-CoA dehydrogenase - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_N k59_684727_1 1088721.NSU_1425 6.44e-127 375.0 COG1508@1|root,COG1508@2|Bacteria,1MW4V@1224|Proteobacteria,2TS41@28211|Alphaproteobacteria,2K182@204457|Sphingomonadales 204457|Sphingomonadales K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released rpoN - - ko:K03092 ko02020,ko05111,map02020,map05111 - - - ko00000,ko00001,ko03021 - - - Sigma54_AID,Sigma54_CBD,Sigma54_DBD k59_1701639_1 2340.JV46_03690 2.41e-62 206.0 COG1109@1|root,COG1109@2|Bacteria,1MU24@1224|Proteobacteria,1RMR2@1236|Gammaproteobacteria,1J55X@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria G Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate glmM GO:0003674,GO:0003824,GO:0004614,GO:0004615,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006040,GO:0006047,GO:0006048,GO:0006139,GO:0006464,GO:0006468,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008966,GO:0009058,GO:0009225,GO:0009226,GO:0009987,GO:0016310,GO:0016853,GO:0016866,GO:0016868,GO:0018130,GO:0019438,GO:0019538,GO:0034641,GO:0034654,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046349,GO:0046483,GO:0046777,GO:0055086,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901576 5.4.2.10 ko:K03431 ko00520,ko01100,ko01130,map00520,map01100,map01130 - R02060 RC00408 ko00000,ko00001,ko01000 - - iSBO_1134.SBO_3206 PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV k59_1532628_1 1499967.BAYZ01000197_gene3021 9.3e-253 723.0 2DSKR@1|root,33GIU@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - RepB_primase k59_1532628_2 1472418.BBJC01000005_gene2187 1.58e-81 251.0 COG0603@1|root,COG0603@2|Bacteria,1MU5V@1224|Proteobacteria,2TU7F@28211|Alphaproteobacteria 28211|Alphaproteobacteria F Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) queC - 6.3.4.20 ko:K06920 ko00790,ko01100,map00790,map01100 - R09978 RC00959 ko00000,ko00001,ko01000,ko03016 - - - QueC k59_1532628_3 1070319.CAGGBEG34_300026 1.05e-27 107.0 COG0720@1|root,COG0720@2|Bacteria,1RETG@1224|Proteobacteria,2VRBN@28216|Betaproteobacteria,1K4ID@119060|Burkholderiaceae 28216|Betaproteobacteria H synthase queD - 4.1.2.50,4.2.3.12 ko:K01737 ko00790,ko01100,map00790,map01100 M00842,M00843 R04286,R09959 RC01117,RC02846,RC02847 ko00000,ko00001,ko00002,ko01000,ko03016 - - - PTPS k59_1532628_4 272562.CA_C3625 1.46e-24 104.0 COG0602@1|root,COG0602@2|Bacteria,1TQ58@1239|Firmicutes,2499R@186801|Clostridia,36HKB@31979|Clostridiaceae 186801|Clostridia H Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds queE - 4.3.99.3 ko:K10026 ko00790,ko01100,map00790,map01100 - R10002 RC02989 ko00000,ko00001,ko01000,ko03016 - - - Fer4_12,Fer4_14,Radical_SAM k59_1532628_6 1278078.G419_00770 8.47e-35 129.0 COG0302@1|root,COG0302@2|Bacteria,2GP2P@201174|Actinobacteria,4FX8Q@85025|Nocardiaceae 201174|Actinobacteria H GTP cyclohydrolase folE GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003933,GO:0003934,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006066,GO:0006725,GO:0006729,GO:0006732,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009108,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019238,GO:0019438,GO:0019751,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034311,GO:0034312,GO:0034641,GO:0035639,GO:0036094,GO:0040007,GO:0042558,GO:0042559,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046146,GO:0046165,GO:0046173,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 3.5.4.16 ko:K01495 ko00790,ko01100,map00790,map01100 M00126,M00841,M00842,M00843 R00428,R04639,R05046,R05048 RC00263,RC00294,RC00323,RC00945,RC01188 ko00000,ko00001,ko00002,ko01000 - - iNJ661.Rv3609c GTP_cyclohydroI k59_1532628_7 999630.TUZN_0848 9.46e-11 62.0 COG1694@1|root,arCOG01084@2157|Archaea 2157|Archaea S PFAM MazG nucleotide pyrophosphohydrolase - - - - - - - - - - - - MazG,MazG-like k59_1532628_10 1499967.BAYZ01000197_gene3019 5.84e-198 585.0 COG0749@1|root,COG0749@2|Bacteria,2NNKA@2323|unclassified Bacteria 2|Bacteria L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity - - - - - - - - - - - - DNA_pol_A,DNA_pol_A_exo1 k59_1419160_1 314285.KT71_17626 6.18e-101 302.0 COG1741@1|root,COG1741@2|Bacteria,1MWIP@1224|Proteobacteria,1RNVM@1236|Gammaproteobacteria,1J55F@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Belongs to the pirin family - - - ko:K06911 - - - - ko00000 - - - Pirin,Pirin_C k59_628294_2 648757.Rvan_0803 1.23e-16 74.3 COG0745@1|root,COG0745@2|Bacteria,1RHDD@1224|Proteobacteria,2U9G2@28211|Alphaproteobacteria,3N751@45401|Hyphomicrobiaceae 28211|Alphaproteobacteria T cheY-homologous receiver domain cheY3 - - ko:K03413 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko02022,ko02035 - - - Response_reg k59_684739_1 1122137.AQXF01000002_gene398 4.74e-42 147.0 COG3147@1|root,COG3147@2|Bacteria,1QZWI@1224|Proteobacteria,2UKVR@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Sporulation related domain - - - - - - - - - - - - SPOR k59_1419162_1 1122137.AQXF01000003_gene2430 7.66e-196 565.0 COG0272@1|root,COG0272@2|Bacteria,1MV3R@1224|Proteobacteria,2TRHK@28211|Alphaproteobacteria 28211|Alphaproteobacteria L DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA ligA GO:0003674,GO:0003824,GO:0003909,GO:0003911,GO:0006139,GO:0006259,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016874,GO:0016886,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360 6.5.1.2 ko:K01972 ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430 - R00382 RC00005 ko00000,ko00001,ko01000,ko03032,ko03400 - - - BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2 k59_232670_1 1205680.CAKO01000038_gene1710 7.76e-56 186.0 COG1702@1|root,COG1702@2|Bacteria,1MVDV@1224|Proteobacteria,2TRV3@28211|Alphaproteobacteria,2JPRI@204441|Rhodospirillales 204441|Rhodospirillales T COG1702 Phosphate starvation-inducible protein PhoH ybeZ - - ko:K06217 - - - - ko00000 - - - PhoH k59_1645712_1 382464.ABSI01000002_gene4324 8.03e-47 158.0 COG0811@1|root,COG0811@2|Bacteria,46VPT@74201|Verrucomicrobia,2IWJ2@203494|Verrucomicrobiae 203494|Verrucomicrobiae U MotA/TolQ/ExbB proton channel family - - - - - - - - - - - - MotA_ExbB k59_854866_1 1038869.AXAN01000264_gene587 4.15e-33 126.0 COG3547@1|root,COG3547@2|Bacteria,1MW0N@1224|Proteobacteria,2VWYN@28216|Betaproteobacteria,1K8UX@119060|Burkholderiaceae 28216|Betaproteobacteria L Transposase IS116/IS110/IS902 family - - - ko:K07486 - - - - ko00000 - - - Transposase_20 k59_1193421_1 1137281.D778_01999 5.96e-22 92.0 2E0H2@1|root,32W2Y@2|Bacteria,4NT2B@976|Bacteroidetes 976|Bacteroidetes - - - - - - - - - - - - - - - k59_1193421_2 1501391.LG35_08625 8.82e-09 55.5 COG0451@1|root,COG0451@2|Bacteria,4NE3U@976|Bacteroidetes,2FNS7@200643|Bacteroidia,22U36@171550|Rikenellaceae 976|Bacteroidetes GM NAD dependent epimerase dehydratase family ltd - - - - - - - - - - - Epimerase k59_1758276_1 1537994.JQFW01000006_gene3050 2e-68 231.0 COG1629@1|root,COG1629@2|Bacteria,1MWTT@1224|Proteobacteria,1RRQ9@1236|Gammaproteobacteria,464SZ@72275|Alteromonadaceae 1236|Gammaproteobacteria P COG1629 Outer membrane receptor proteins, mostly Fe transport - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - OMP_b-brl_3,Plug,TonB_dep_Rec k59_514968_1 595460.RRSWK_04967 2.49e-59 200.0 COG1012@1|root,COG1012@2|Bacteria,2IYRE@203682|Planctomycetes 203682|Planctomycetes C ketoglutarate semialdehyde dehydrogenase - - 1.2.1.26 ko:K13877 ko00040,ko00053,map00040,map00053 - R00264 RC00080 ko00000,ko00001,ko01000 - - - Aldedh k59_402410_1 713587.THITH_00945 8.44e-55 187.0 COG0728@1|root,COG0728@2|Bacteria,1MUH0@1224|Proteobacteria,1RMXX@1236|Gammaproteobacteria,1WWAE@135613|Chromatiales 135613|Chromatiales S Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane murJ - - ko:K03980 - - - - ko00000,ko01011,ko02000 2.A.66.4 - - MVIN k59_458930_1 258594.RPA1401 1.74e-45 162.0 COG0174@1|root,COG0174@2|Bacteria,1MU6V@1224|Proteobacteria,2VG5K@28211|Alphaproteobacteria,3JTG6@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria E Belongs to the glutamine synthetase family - - 6.3.1.2 ko:K01915 ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 - R00253 RC00010,RC02798 ko00000,ko00001,ko01000,ko04147 - - - Gln-synt_C k59_1588501_1 1283284.AZUK01000001_gene1443 6.99e-15 75.5 COG3219@1|root,COG3219@2|Bacteria,1QAP4@1224|Proteobacteria,1S59S@1236|Gammaproteobacteria,1Y6F3@135624|Aeromonadales 135624|Aeromonadales S Putative DNA-binding domain - - - - - - - - - - - - DUF2063 k59_1588501_2 351016.RAZWK3B_12127 2.3e-50 170.0 COG3220@1|root,COG3220@2|Bacteria,1MURE@1224|Proteobacteria,2TRZJ@28211|Alphaproteobacteria,2P1A2@2433|Roseobacter 28211|Alphaproteobacteria S protein conserved in bacteria - - - ko:K09930 - - - - ko00000 - - - DUF692 k59_1193424_2 1036674.A28LD_0136 5.08e-22 95.9 COG0621@1|root,COG0621@2|Bacteria,1MURS@1224|Proteobacteria,1RMD8@1236|Gammaproteobacteria,2QFGJ@267893|Idiomarinaceae 1236|Gammaproteobacteria J Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine miaB GO:0001510,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016782,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0035596,GO:0035597,GO:0035600,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050497,GO:0051536,GO:0051539,GO:0051540,GO:0071704,GO:0090304,GO:1901360 2.8.4.3 ko:K06168 - - R10645,R10646,R10647 RC00003,RC00980,RC03221,RC03222 ko00000,ko01000,ko03016 - - - Radical_SAM,TRAM,UPF0004 k59_1758284_1 1236902.ANAS01000009_gene2575 1.75e-68 222.0 COG3507@1|root,COG3507@2|Bacteria,2GIYA@201174|Actinobacteria,4EFK0@85012|Streptosporangiales 201174|Actinobacteria G Glycosyl hydrolases family 43 - - 3.2.1.99 ko:K06113 - - - - ko00000,ko01000 - GH43 - Glyco_hydro_43,RicinB_lectin_2 k59_346528_1 1123366.TH3_14749 1.63e-38 150.0 COG0457@1|root,COG0457@2|Bacteria,1N1I4@1224|Proteobacteria,2V9ES@28211|Alphaproteobacteria,2JTPA@204441|Rhodospirillales 204441|Rhodospirillales S COG0457 FOG TPR repeat - - - - - - - - - - - - DUF560,TPR_19 k59_458942_1 765914.ThisiDRAFT_1744 1.08e-73 248.0 COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,1MV6G@1224|Proteobacteria,1RMYD@1236|Gammaproteobacteria,1WW84@135613|Chromatiales 135613|Chromatiales E Vitamin B12 dependent methionine synthase activation metH - 2.1.1.13 ko:K00548 ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230 M00017 R00946,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 - - - B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans k59_1193428_1 1265502.KB905933_gene1996 1.83e-33 132.0 COG0471@1|root,COG0471@2|Bacteria,1MU0K@1224|Proteobacteria,2VP0G@28216|Betaproteobacteria 28216|Betaproteobacteria P COG0471 Di- and tricarboxylate transporters sdcS - - - - - - - - - - - CitMHS,Na_sulph_symp,TrkA_C k59_402426_1 344747.PM8797T_11409 4.38e-30 115.0 COG1225@1|root,COG1225@2|Bacteria,2IZ7G@203682|Planctomycetes 203682|Planctomycetes O PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen - - - - - - - - - - - - AhpC-TSA,Redoxin k59_458945_1 1123073.KB899243_gene803 5.67e-35 132.0 COG1003@1|root,COG1003@2|Bacteria,1MUDP@1224|Proteobacteria,1RND3@1236|Gammaproteobacteria,1X35C@135614|Xanthomonadales 135614|Xanthomonadales E The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor gcvP - 1.4.4.2 ko:K00281,ko:K00283 ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200 M00532 R01221,R03425 RC00022,RC00929,RC02834,RC02880 ko00000,ko00001,ko00002,ko01000 - - - GDC-P k59_458945_2 153948.NAL212_1912 7.05e-11 62.8 COG0403@1|root,COG0403@2|Bacteria,1MVC1@1224|Proteobacteria,2VKQB@28216|Betaproteobacteria,3720Y@32003|Nitrosomonadales 28216|Betaproteobacteria E The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor gcvPA - 1.4.4.2 ko:K00282 ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200 - R01221,R03425 RC00022,RC00929,RC02834,RC02880 ko00000,ko00001,ko01000 - - - GDC-P k59_232711_1 631362.Thi970DRAFT_00892 1.13e-55 184.0 COG4973@1|root,COG4973@2|Bacteria,1MUJJ@1224|Proteobacteria,1RMJG@1236|Gammaproteobacteria,1WW4W@135613|Chromatiales 135613|Chromatiales L Belongs to the 'phage' integrase family. XerC subfamily xerC - - ko:K03733 - - - - ko00000,ko03036 - - - Phage_int_SAM_1,Phage_integrase k59_1532650_2 436308.Nmar_0442 2.92e-59 184.0 arCOG08760@1|root,arCOG08760@2157|Archaea,41T7P@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_7372_1 1089550.ATTH01000001_gene1196 2.87e-61 206.0 COG2225@1|root,COG2225@2|Bacteria,4NF5H@976|Bacteroidetes,1FJVN@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes C Malate synthase aceB - 2.3.3.9 ko:K01638 ko00620,ko00630,ko01100,ko01110,ko01120,ko01200,map00620,map00630,map01100,map01110,map01120,map01200 M00012 R00472 RC00004,RC00308,RC02747 ko00000,ko00001,ko00002,ko01000 - - - Malate_synthase k59_1024600_1 56780.SYN_00588 8.59e-30 115.0 COG0356@1|root,COG0356@2|Bacteria,1MV87@1224|Proteobacteria,42NR9@68525|delta/epsilon subdivisions,2WKX1@28221|Deltaproteobacteria,2MQSN@213462|Syntrophobacterales 28221|Deltaproteobacteria C it plays a direct role in the translocation of protons across the membrane atpB - - ko:K02108 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko03110 3.A.2.1 - - ATP-synt_A k59_1701672_1 1549858.MC45_16735 8.63e-26 106.0 COG0657@1|root,COG0657@2|Bacteria,1N2XW@1224|Proteobacteria,2U3QT@28211|Alphaproteobacteria,2K2SB@204457|Sphingomonadales 204457|Sphingomonadales I Carboxylesterase family - - - - - - - - - - - - Abhydrolase_3 k59_1701672_2 118005.AWNK01000006_gene1372 1.39e-76 242.0 COG1611@1|root,COG1611@2|Bacteria 2|Bacteria S cytokinin biosynthetic process fas6 - 3.2.2.10 ko:K06966 ko00230,ko00240,map00230,map00240 - R00182,R00510 RC00063,RC00318 ko00000,ko00001,ko01000 - - - Lysine_decarbox k59_1249877_1 1123355.JHYO01000028_gene2715 1.9e-22 100.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,2TQR7@28211|Alphaproteobacteria,36Y67@31993|Methylocystaceae 28211|Alphaproteobacteria NT Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - HAMP,MCPsignal,Protoglobin k59_1249877_2 880070.Cycma_4545 4.87e-14 71.6 COG0462@1|root,COG0462@2|Bacteria,4NFX7@976|Bacteroidetes,47TI4@768503|Cytophagia 976|Bacteroidetes F COGs COG0462 Phosphoribosylpyrophosphate synthetase - - 2.7.6.1 ko:K00948 ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230 M00005 R01049 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - Pribosyltran,Pribosyltran_N k59_1080295_1 166318.Syn8016DRAFT_2329 4e-60 188.0 COG0229@1|root,COG0229@2|Bacteria,1G5S6@1117|Cyanobacteria,1H0VR@1129|Synechococcus 1117|Cyanobacteria C Belongs to the MsrB Met sulfoxide reductase family msrB - 1.8.4.12 ko:K07305 - - - - ko00000,ko01000 - - - SelR k59_514986_1 316407.85675061 1.52e-92 279.0 COG1902@1|root,COG1902@2|Bacteria,1MVIX@1224|Proteobacteria,1RMFI@1236|Gammaproteobacteria,3XMN8@561|Escherichia 1236|Gammaproteobacteria C N-ethylmaleimide reductase activity nemA GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006805,GO:0006807,GO:0008150,GO:0008152,GO:0008748,GO:0009056,GO:0009410,GO:0009987,GO:0010181,GO:0016491,GO:0016627,GO:0016628,GO:0016661,GO:0017144,GO:0018937,GO:0018973,GO:0018974,GO:0019326,GO:0019439,GO:0032553,GO:0034567,GO:0036094,GO:0042221,GO:0042537,GO:0043167,GO:0043168,GO:0044237,GO:0044248,GO:0044424,GO:0044444,GO:0044464,GO:0046256,GO:0046260,GO:0046263,GO:0046857,GO:0048037,GO:0050662,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0071466,GO:0071704,GO:0072490,GO:0072491,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901361,GO:1901363,GO:1901575 - ko:K10680 ko00633,ko01120,map00633,map01120 - R08014,R08017,R08042 RC00250 ko00000,ko00001,ko01000 - - - Oxidored_FMN k59_290028_1 745411.B3C1_09687 5.85e-95 297.0 COG2303@1|root,COG2303@2|Bacteria,1MV19@1224|Proteobacteria,1RMD2@1236|Gammaproteobacteria,1J4PV@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Belongs to the GMC oxidoreductase family - - 1.1.99.1 ko:K00108 ko00260,ko01100,map00260,map01100 M00555 R01025 RC00087 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,GMC_oxred_C,GMC_oxred_N k59_290028_2 172088.AUGA01000001_gene6237 9.5e-16 80.5 COG1752@1|root,COG1752@2|Bacteria,1Q82E@1224|Proteobacteria,2TU9N@28211|Alphaproteobacteria,3JTC1@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S Esterase of the alpha-beta hydrolase superfamily - - - - - - - - - - - - Patatin k59_402459_1 1234364.AMSF01000037_gene208 3.75e-70 218.0 COG0778@1|root,COG0778@2|Bacteria,1MY39@1224|Proteobacteria,1RS8B@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Nitroreductase - - - - - - - - - - - - Nitroreductase k59_1363034_1 1168059.KB899087_gene1539 1.57e-12 67.0 COG0061@1|root,COG0061@2|Bacteria,1MUBC@1224|Proteobacteria,2TSKN@28211|Alphaproteobacteria,3EXWM@335928|Xanthobacteraceae 28211|Alphaproteobacteria G Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP nadK - 2.7.1.23 ko:K00858 ko00760,ko01100,map00760,map01100 - R00104 RC00002,RC00078 ko00000,ko00001,ko01000 - - - NAD_kinase k59_458971_1 398720.MED217_17835 9e-110 324.0 COG0798@1|root,COG0798@2|Bacteria,4NFG7@976|Bacteroidetes,1HWT1@117743|Flavobacteriia,2XK4N@283735|Leeuwenhoekiella 976|Bacteroidetes P Sodium Bile acid symporter family acr3 - - ko:K03325 - - - - ko00000,ko02000 2.A.59 - - SBF k59_458971_2 1250232.JQNJ01000001_gene105 5.73e-11 60.8 COG0394@1|root,COG0394@2|Bacteria,4NE8C@976|Bacteroidetes,1HYIW@117743|Flavobacteriia 976|Bacteroidetes T Protein tyrosine phosphatase - - 1.20.4.1 ko:K03741 - - - - ko00000,ko01000 - - - - k59_1758321_1 745718.JADT01000001_gene1670 7.6e-84 267.0 COG2304@1|root,COG2304@2|Bacteria,4NFX3@976|Bacteroidetes,1HY6K@117743|Flavobacteriia 976|Bacteroidetes M von Willebrand factor, type A yfbK - - ko:K07114 - - - - ko00000,ko02000 1.A.13.2.2,1.A.13.2.3 - - CarbopepD_reg_2,DUF3520,Plug,TSP_3,VWA,vWF_A k59_7406_1 1089550.ATTH01000001_gene1175 2.09e-17 87.4 COG0243@1|root,COG0437@1|root,COG0243@2|Bacteria,COG0437@2|Bacteria,4NE5M@976|Bacteroidetes,1FJ0U@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes C 4Fe-4S dicluster domain nrfC - - ko:K00184 - - - - ko00000 5.A.3 - - Fer4_7,Molydop_binding k59_1363058_1 880073.Calab_2363 5.92e-63 204.0 COG0472@1|root,COG0472@2|Bacteria,2NNQW@2323|unclassified Bacteria 2|Bacteria M First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan mraY GO:0000270,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008963,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016780,GO:0030203,GO:0034645,GO:0040007,GO:0042546,GO:0042802,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044464,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 2.7.8.13 ko:K01000 ko00550,ko01100,ko01502,map00550,map01100,map01502 - R05629,R05630 RC00002,RC02753 ko00000,ko00001,ko01000,ko01011 9.B.146 - iAF987.Gmet_0409,iEC042_1314.EC042_0088,iECABU_c1320.ECABU_c00920,iECED1_1282.ECED1_0088,iECH74115_1262.ECH74115_0095,iECSP_1301.ECSP_0090,iECs_1301.ECs0091,iG2583_1286.G2583_0091,iSDY_1059.SDY_0117,iZ_1308.Z0097,ic_1306.c0105 Glycos_transf_4,MraY_sig1 k59_1476247_1 1144305.PMI02_04949 2.16e-122 358.0 COG0414@1|root,COG0414@2|Bacteria,1MV1S@1224|Proteobacteria,2TS2D@28211|Alphaproteobacteria,2K0S2@204457|Sphingomonadales 204457|Sphingomonadales H Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate panC - 6.3.2.1 ko:K01918 ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110 M00119 R02473 RC00096,RC00141 ko00000,ko00001,ko00002,ko01000 - - - Pantoate_ligase k59_515019_1 1192759.AKIB01000069_gene3854 1.88e-80 253.0 COG2303@1|root,COG2303@2|Bacteria,1MV19@1224|Proteobacteria,2TQKQ@28211|Alphaproteobacteria,2K0FF@204457|Sphingomonadales 204457|Sphingomonadales E Belongs to the GMC oxidoreductase family - - 1.1.99.1 ko:K00108 ko00260,ko01100,map00260,map01100 M00555 R01025 RC00087 ko00000,ko00001,ko00002,ko01000 - - - GMC_oxred_C,GMC_oxred_N k59_7414_1 357808.RoseRS_0444 1.58e-82 259.0 COG3385@1|root,COG3385@2|Bacteria,2G9A6@200795|Chloroflexi 200795|Chloroflexi L PFAM transposase, IS4 family protein - - - - - - - - - - - - DDE_Tnp_1 k59_571737_2 1111729.ATYV01000001_gene2196 1.21e-56 183.0 COG0563@1|root,COG0563@2|Bacteria,2IGX9@201174|Actinobacteria,22PAE@1653|Corynebacteriaceae 201174|Actinobacteria F adenylate kinase activity - - - - - - - - - - - - AAA,AAA_33,SKI k59_967244_1 1232683.ADIMK_0855 4.2e-09 57.0 2F71N@1|root,33ZH9@2|Bacteria,1NXSR@1224|Proteobacteria,1SPX7@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_967244_2 443143.GM18_0106 2.41e-39 148.0 COG1629@1|root,COG4771@2|Bacteria,1MUC1@1224|Proteobacteria,42R8H@68525|delta/epsilon subdivisions,2WMWF@28221|Deltaproteobacteria,43T80@69541|Desulfuromonadales 28221|Deltaproteobacteria P TonB dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - PEGA,Plug,TonB_dep_Rec k59_1193484_1 1120999.JONM01000035_gene4196 1.74e-21 99.0 COG1020@1|root,COG1020@2|Bacteria,1QK4F@1224|Proteobacteria,2VHRU@28216|Betaproteobacteria,2KQ86@206351|Neisseriales 206351|Neisseriales Q Condensation domain - - - - - - - - - - - - AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase k59_911121_2 1323663.AROI01000004_gene2153 2.82e-49 168.0 COG0438@1|root,COG0438@2|Bacteria,1NE3V@1224|Proteobacteria,1RQE3@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Catalyzes the addition of the first glucose residue to the LPS core rfaG GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008194,GO:0008610,GO:0008653,GO:0008919,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033692,GO:0034637,GO:0034645,GO:0035251,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0046401,GO:0046527,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 - ko:K02844 ko00540,ko01100,map00540,map01100 M00080 - - ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT4 iSDY_1059.SDY_4061 Glyco_transf_4,Glycos_transf_1 k59_854993_1 1392490.JHZX01000001_gene2028 5.3e-116 367.0 COG4677@1|root,COG4677@2|Bacteria,4PNFN@976|Bacteroidetes,1I0J5@117743|Flavobacteriia 976|Bacteroidetes G repeat protein - - - - - - - - - - - - Pectinesterase,TSP_3 k59_1136848_1 1280944.HY17_17695 2.88e-99 301.0 COG3182@1|root,COG3182@2|Bacteria,1MVET@1224|Proteobacteria,2U200@28211|Alphaproteobacteria,43WK3@69657|Hyphomonadaceae 28211|Alphaproteobacteria S PepSY-associated TM region - - - - - - - - - - - - PepSY_TM k59_685734_1 269799.Gmet_1774 5.04e-96 308.0 COG0458@1|root,COG0458@2|Bacteria,1MUDZ@1224|Proteobacteria,42MGK@68525|delta/epsilon subdivisions,2WJQH@28221|Deltaproteobacteria,43TR2@69541|Desulfuromonadales 28221|Deltaproteobacteria F PFAM Carbamoyl-phosphate synthase L chain ATP-binding carB - 6.3.5.5 ko:K01955 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - - CPSase_L_D2,CPSase_L_D3,MGS k59_1477418_1 555079.Toce_2279 3.53e-27 111.0 COG0445@1|root,COG0445@2|Bacteria,1TQ4B@1239|Firmicutes,247U2@186801|Clostridia,42F32@68295|Thermoanaerobacterales 186801|Clostridia D NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 gidA - - ko:K03495 - - R08701 RC00053,RC00209,RC00870 ko00000,ko03016,ko03036 - - - GIDA,GIDA_assoc k59_1477418_2 871963.Desdi_3529 4.25e-13 68.6 COG0357@1|root,COG0357@2|Bacteria,1TPBT@1239|Firmicutes,247WM@186801|Clostridia,261UV@186807|Peptococcaceae 186801|Clostridia J Specifically methylates the N7 position of a guanine in 16S rRNA rsmG - 2.1.1.170 ko:K03501 - - - - ko00000,ko01000,ko03009,ko03036 - - - GidB k59_1477420_1 1406840.Q763_01785 6.67e-80 249.0 COG0621@1|root,COG0621@2|Bacteria,4NE0R@976|Bacteroidetes,1HWYI@117743|Flavobacteriia,2NT12@237|Flavobacterium 976|Bacteroidetes J 2-methylthioadenine synthetase yqeV - 2.8.4.5 ko:K18707 - - R10649 RC00003,RC03221 ko00000,ko01000,ko03016 - - - Radical_SAM,UPF0004 k59_856007_1 391615.ABSJ01000039_gene1793 1.34e-87 267.0 COG0752@1|root,COG0752@2|Bacteria,1MVCJ@1224|Proteobacteria,1RMYI@1236|Gammaproteobacteria,1J50F@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J glycyl-tRNA synthetase, alpha subunit glyQ GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 6.1.1.14 ko:K01878 ko00970,map00970 M00360 R03654 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iAF1260.b3560,iJO1366.b3560,iPC815.YPO4072,iY75_1357.Y75_RS19360 tRNA-synt_2e k59_65209_1 1440774.Y900_030265 6.81e-52 175.0 COG0175@1|root,COG0175@2|Bacteria,2IBEQ@201174|Actinobacteria,23D38@1762|Mycobacteriaceae 201174|Actinobacteria EH Phosphoadenosine phosphosulfate reductase family - - - - - - - - - - - - PAPS_reduct k59_1364254_1 331869.BAL199_24389 3.98e-29 125.0 COG1629@1|root,COG4771@2|Bacteria,1MUC1@1224|Proteobacteria,2U16R@28211|Alphaproteobacteria 28211|Alphaproteobacteria P TonB-dependent Receptor Plug Domain - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_856009_1 1304284.L21TH_1525 6.64e-60 199.0 COG1173@1|root,COG1173@2|Bacteria,1TP4R@1239|Firmicutes,2489T@186801|Clostridia,36E1E@31979|Clostridiaceae 186801|Clostridia EP PFAM binding-protein-dependent transport systems inner membrane component - - - ko:K02034 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1,OppC_N,RCC1_2 k59_1081546_1 322710.Avin_09050 3.06e-27 103.0 COG0319@1|root,COG0319@2|Bacteria,1MZ67@1224|Proteobacteria,1S6BS@1236|Gammaproteobacteria 1236|Gammaproteobacteria J Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA ybeY GO:0000469,GO:0000478,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0005488,GO:0006139,GO:0006355,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0016072,GO:0016151,GO:0016787,GO:0016788,GO:0016892,GO:0016894,GO:0019219,GO:0019222,GO:0019538,GO:0022613,GO:0030490,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042274,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043244,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0046483,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0071840,GO:0080090,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1903506,GO:2000112,GO:2001141 - ko:K07042 - - - - ko00000,ko03009 - - - UPF0054 k59_1081546_2 396014.BF93_06185 1.44e-10 64.7 COG1253@1|root,COG1253@2|Bacteria,2GIWR@201174|Actinobacteria,4FCDS@85020|Dermabacteraceae 201174|Actinobacteria S Transporter associated domain corC GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - - - - - - - - - - CBS,CorC_HlyC,DUF21 k59_1307702_1 243365.CV_2233 1.09e-57 203.0 COG1020@1|root,COG3319@1|root,COG1020@2|Bacteria,COG3319@2|Bacteria,1QK4F@1224|Proteobacteria,2VHRU@28216|Betaproteobacteria,2KSHA@206351|Neisseriales 206351|Neisseriales Q Condensation domain - - - - - - - - - - - - AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase k59_572876_1 471852.Tcur_4385 1.87e-10 60.8 COG1005@1|root,COG1005@2|Bacteria,2GN3R@201174|Actinobacteria,4EHPA@85012|Streptosporangiales 201174|Actinobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone nuoH2 - 1.6.5.3 ko:K00337 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - NADHdh k59_572876_2 1440053.JOEI01000008_gene6270 9.8e-68 210.0 COG1143@1|root,COG1143@2|Bacteria,2GPSS@201174|Actinobacteria 201174|Actinobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoI2 - 1.6.5.3 ko:K00338 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Fer4 k59_1764981_1 316407.85675596 1.46e-166 464.0 COG0602@1|root,COG0602@2|Bacteria,1MUJ2@1224|Proteobacteria,1RNQZ@1236|Gammaproteobacteria,3XMSU@561|Escherichia 1236|Gammaproteobacteria F Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds queE GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 4.3.99.3 ko:K10026 ko00790,ko01100,map00790,map01100 - R10002 RC02989 ko00000,ko00001,ko01000,ko03016 - - - Fer4_14,Radical_SAM k59_1764982_1 1122137.AQXF01000001_gene2938 9.23e-64 196.0 COG4323@1|root,COG4323@2|Bacteria,1N16T@1224|Proteobacteria,2U9EX@28211|Alphaproteobacteria 28211|Alphaproteobacteria S membrane - - - - - - - - - - - - DUF962 k59_1764982_2 1220535.IMCC14465_06230 7.88e-14 70.1 COG0730@1|root,COG0730@2|Bacteria,1MWX2@1224|Proteobacteria,2TRIC@28211|Alphaproteobacteria,4BPDR@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria S membrane transporter protein MA20_19835 - - ko:K07090 - - - - ko00000 - - - TauE k59_635103_1 436308.Nmar_0382 3.59e-100 295.0 COG0081@1|root,arCOG04289@2157|Archaea,41SHF@651137|Thaumarchaeota 651137|Thaumarchaeota J Binds directly to 23S rRNA. Probably involved in E site tRNA release rpl1 - - ko:K02863 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L1 k59_14149_1 1229909.NSED_05350 2.23e-34 122.0 COG0784@1|root,arCOG02391@2157|Archaea 2157|Archaea T response regulator, receiver - - - ko:K03413,ko:K07662,ko:K07667 ko01503,ko02020,ko02024,ko02030,map01503,map02020,map02024,map02030 M00447,M00454,M00506,M00727,M00728 - - ko00000,ko00001,ko00002,ko02022,ko02035 - - - CHASE4,HATPase_c,HisKA,Hpt,PAS_4,PAS_9,Response_reg k59_917617_1 888050.HMPREF9004_1073 6.31e-11 63.5 COG4770@1|root,COG4770@2|Bacteria,2GIZP@201174|Actinobacteria,4D38Q@85005|Actinomycetales 201174|Actinobacteria I Psort location Cytoplasmic, score accC - 6.3.4.14,6.4.1.2,6.4.1.3 ko:K11263 ko00061,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00741 R00742,R01859,R04385 RC00040,RC00097,RC00253,RC00367,RC00609 ko00000,ko00001,ko00002,ko01000 - - - Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2 k59_917617_2 319224.Sputcn32_1031 1.33e-43 152.0 COG1883@1|root,COG1883@2|Bacteria,1MV0G@1224|Proteobacteria,1RP3W@1236|Gammaproteobacteria,2Q8YR@267890|Shewanellaceae 1236|Gammaproteobacteria C PFAM Na transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit oadB - 4.1.1.3 ko:K01572 ko00620,ko01100,map00620,map01100 - R00217 RC00040 ko00000,ko00001,ko01000,ko02000 3.B.1.1.1 - - OAD_beta k59_521639_1 1313421.JHBV01000020_gene5288 2.76e-05 52.4 COG0747@1|root,COG0747@2|Bacteria 2|Bacteria E dipeptide transport oppA_5 - - ko:K02035,ko:K13893 ko02010,ko02024,map02010,map02024 M00239,M00349 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5,3.A.1.5.21,3.A.1.5.24 - - SBP_bac_5 k59_1200244_1 313606.M23134_07634 1.31e-45 159.0 COG1266@1|root,COG1266@2|Bacteria,4NJAV@976|Bacteroidetes 2|Bacteria S CAAX protease self-immunity - - - ko:K07052 - - - - ko00000 - - - Abi k59_1652418_1 1198114.AciX9_1671 4.72e-88 265.0 COG1136@1|root,COG1136@2|Bacteria,3Y2J0@57723|Acidobacteria,2JIKD@204432|Acidobacteriia 204432|Acidobacteriia V ABC transporter - - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_1652420_1 1489678.RDMS_11430 7.49e-20 95.5 COG2272@1|root,COG2272@2|Bacteria,1WI3P@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus I Belongs to the type-B carboxylesterase lipase family - - - ko:K03929 - - - - ko00000,ko01000 - CE10 - COesterase k59_917622_1 1122621.ATZA01000007_gene842 3.06e-21 98.2 COG2204@1|root,COG2204@2|Bacteria,4NE89@976|Bacteroidetes,1INN4@117747|Sphingobacteriia 976|Bacteroidetes T COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains zraR - - ko:K07713 ko02020,map02020 M00499 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_71018_1 1484460.JSWG01000012_gene1424 2.46e-155 449.0 COG0138@1|root,COG0138@2|Bacteria,4NEZD@976|Bacteroidetes,1HXDR@117743|Flavobacteriia 976|Bacteroidetes F Bifunctional purine biosynthesis protein PurH purH - 2.1.2.3,3.5.4.10 ko:K00602 ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523 M00048 R01127,R04560 RC00026,RC00263,RC00456 ko00000,ko00001,ko00002,ko01000,ko04147 - - - AICARFT_IMPCHas,MGS k59_635125_2 640081.Dsui_1989 7.41e-65 200.0 COG0360@1|root,COG0360@2|Bacteria,1RH82@1224|Proteobacteria,2VR79@28216|Betaproteobacteria,2KWGN@206389|Rhodocyclales 206389|Rhodocyclales J Binds together with S18 to 16S ribosomal RNA rpsF - - ko:K02990 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011,ko03029 - - - Ribosomal_S6 k59_805172_1 160488.PP_0305 1.46e-61 204.0 COG4977@1|root,COG4977@2|Bacteria,1MUDK@1224|Proteobacteria,1SMIT@1236|Gammaproteobacteria,1YVA2@136845|Pseudomonas putida group 1236|Gammaproteobacteria K Transcriptional regulator cdhR - - ko:K17736 - - - - ko00000,ko03000 - - - DJ-1_PfpI,HTH_18 k59_1313708_1 316407.4062212 1.22e-124 375.0 COG1629@1|root,COG4771@2|Bacteria,1MUC1@1224|Proteobacteria,1RNHR@1236|Gammaproteobacteria,3XNAQ@561|Escherichia 1236|Gammaproteobacteria P This protein is involved in the initial step of iron uptake by binding ferrienterobactin (Fe-ENT), an iron chelatin siderophore that allows E.coli to extract iron from the environment. FepA also acts as a receptor for colicins B and D fepA GO:0000041,GO:0003674,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006826,GO:0006855,GO:0006873,GO:0006875,GO:0006879,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009279,GO:0009987,GO:0015031,GO:0015238,GO:0015267,GO:0015343,GO:0015399,GO:0015405,GO:0015450,GO:0015620,GO:0015682,GO:0015685,GO:0015688,GO:0015711,GO:0015833,GO:0015850,GO:0015891,GO:0015893,GO:0016020,GO:0016021,GO:0019725,GO:0019867,GO:0019904,GO:0022803,GO:0022804,GO:0022834,GO:0022836,GO:0022857,GO:0022884,GO:0022885,GO:0030001,GO:0030003,GO:0030312,GO:0030313,GO:0031224,GO:0031230,GO:0031975,GO:0033036,GO:0033212,GO:0033214,GO:0042221,GO:0042493,GO:0042592,GO:0042886,GO:0042887,GO:0042891,GO:0042895,GO:0042912,GO:0042914,GO:0042930,GO:0043213,GO:0044425,GO:0044462,GO:0044464,GO:0044718,GO:0045184,GO:0045203,GO:0046916,GO:0048878,GO:0050801,GO:0050896,GO:0051179,GO:0051181,GO:0051184,GO:0051234,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0072512,GO:0098771,GO:1901678,GO:1904680 - ko:K16089,ko:K19611 ko02020,map02020 - - - ko00000,ko00001,ko02000 1.B.14.1,1.B.14.1.22,1.B.14.1.3,1.B.14.1.5,1.B.14.10 - iECABU_c1320.ECABU_c06330,iECO103_1326.ECO103_2630,iECP_1309.ECP_0615,iLF82_1304.LF82_0640,iNRG857_1313.NRG857_02640,iSDY_1059.SDY_0512 Plug,TonB_dep_Rec k59_747824_1 715226.ABI_07410 1.71e-33 121.0 COG3824@1|root,COG3824@2|Bacteria,1N18M@1224|Proteobacteria,2UBUK@28211|Alphaproteobacteria,2KGNW@204458|Caulobacterales 204458|Caulobacterales S Zincin-like metallopeptidase - - - - - - - - - - - - Zincin_1 k59_296828_1 1123270.ATUR01000006_gene209 3.04e-42 149.0 COG3804@1|root,COG3804@2|Bacteria,1R6QX@1224|Proteobacteria,2UFD5@28211|Alphaproteobacteria,2K1DW@204457|Sphingomonadales 204457|Sphingomonadales S dihydrodipicolinate reductase - - 1.4.1.12,1.4.1.26 ko:K21672 ko00310,ko00330,ko00472,map00310,map00330,map00472 - R02825,R04200,R04201,R04687,R04688 RC00249,RC00790 ko00000,ko00001,ko01000 - - - DapB_N k59_1200267_1 1121949.AQXT01000002_gene2668 2.73e-22 94.7 COG5394@1|root,COG5394@2|Bacteria,1RHRC@1224|Proteobacteria,2TQWQ@28211|Alphaproteobacteria,43XPT@69657|Hyphomonadaceae 28211|Alphaproteobacteria S Polyhydroxyalkanoate synthesis repressor PhaR phaR - - - - - - - - - - - PHB_acc,PHB_acc_N k59_1200267_2 1122137.AQXF01000001_gene2881 1.76e-51 174.0 COG0477@1|root,COG2814@2|Bacteria,1MVSH@1224|Proteobacteria,2TUEW@28211|Alphaproteobacteria 28211|Alphaproteobacteria EGP Major facilitator Superfamily - - - - - - - - - - - - MFS_1,MFS_1_like,MFS_2,Sugar_tr k59_917655_2 1229909.NSED_09345 2.64e-56 181.0 COG0592@1|root,arCOG00488@2157|Archaea,41S6E@651137|Thaumarchaeota 651137|Thaumarchaeota L Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication pcn - - ko:K04802 ko03030,ko03410,ko03420,ko03430,ko04110,ko04530,ko05161,ko05166,map03030,map03410,map03420,map03430,map04110,map04530,map05161,map05166 M00295 - - ko00000,ko00001,ko00002,ko03032,ko03400 - - - PCNA_C,PCNA_N k59_1483568_1 298655.KI912266_gene4439 3.88e-25 97.8 COG2030@1|root,COG2030@2|Bacteria 2|Bacteria I dehydratase - - - - - - - - - - - - MaoC_dehydratas k59_1483568_2 70448.A0A090M6V7 3.99e-20 92.8 COG0471@1|root,2QPZM@2759|Eukaryota,37TNA@33090|Viridiplantae,34JAH@3041|Chlorophyta 3041|Chlorophyta P divalent anion Na symporter - GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008272,GO:0008509,GO:0015075,GO:0015103,GO:0015116,GO:0015318,GO:0015698,GO:0016020,GO:0022857,GO:0034220,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0072348,GO:0098656,GO:0098660,GO:0098661,GO:1901682,GO:1902358 - - - - - - - - - iRC1080.CRv4_Au5_s10_g542_t1 CitMHS,TrkA_C k59_465574_2 463191.SSEG_05504 2.17e-36 135.0 COG2045@1|root,COG2045@2|Bacteria,2GXP6@201174|Actinobacteria 201174|Actinobacteria H 2-phosphosulpholactate phosphatase comB GO:0003674,GO:0003824,GO:0016829,GO:0016830,GO:0016831,GO:0050545 3.1.3.71 ko:K05979 ko00680,ko01120,map00680,map01120 M00358 R05789 RC00428 ko00000,ko00001,ko00002,ko01000 - - - 2-ph_phosp k59_1031433_1 999141.GME_11132 4.43e-57 187.0 COG0583@1|root,COG0583@2|Bacteria,1NSNV@1224|Proteobacteria,1RPNG@1236|Gammaproteobacteria,1XHP1@135619|Oceanospirillales 135619|Oceanospirillales K transcriptional regulator - - - - - - - - - - - - HTH_1,LysR_substrate k59_1031433_2 257310.BB2130 7.24e-31 119.0 COG0065@1|root,COG0065@2|Bacteria,1MVYR@1224|Proteobacteria,2VHSH@28216|Betaproteobacteria,3T303@506|Alcaligenaceae 28216|Betaproteobacteria E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate leuC - 4.2.1.33,4.2.1.35 ko:K01703 ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230 M00432,M00535 R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170 RC00497,RC00976,RC00977,RC01041,RC01046,RC03072 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase k59_409155_1 436308.Nmar_1589 0.000822 39.3 arCOG10591@1|root,arCOG10591@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_409155_2 436308.Nmar_1588 4e-191 534.0 COG0109@1|root,arCOG00479@2157|Archaea,41SFH@651137|Thaumarchaeota 651137|Thaumarchaeota H Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group - - 2.5.1.141 ko:K02257 ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714 M00154 R07411 RC01786 ko00000,ko00001,ko00002,ko01000,ko01006,ko03029 - - - UbiA k59_1370248_1 765914.ThisiDRAFT_1120 1.36e-50 176.0 COG0062@1|root,COG0063@1|root,COG0062@2|Bacteria,COG0063@2|Bacteria,1MU1Q@1224|Proteobacteria,1RMPS@1236|Gammaproteobacteria,1WW1V@135613|Chromatiales 135613|Chromatiales G Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration nnrD - 4.2.1.136,5.1.99.6 ko:K17758,ko:K17759 - - - - ko00000,ko01000 - - - Carb_kinase,YjeF_N k59_239434_1 391625.PPSIR1_31793 1.19e-14 78.6 COG1994@1|root,COG1994@2|Bacteria,1Q2IJ@1224|Proteobacteria,433TS@68525|delta/epsilon subdivisions,2X3F7@28221|Deltaproteobacteria,2YVTY@29|Myxococcales 28221|Deltaproteobacteria S Peptidase family M50 - - - - - - - - - - - - Peptidase_M50 k59_578692_1 1396858.Q666_07380 7.9e-16 76.6 COG0644@1|root,COG0644@2|Bacteria,1MXQY@1224|Proteobacteria,1SEJ8@1236|Gammaproteobacteria 1236|Gammaproteobacteria C geranylgeranyl reductase - - - - - - - - - - - - FAD_binding_3 k59_578692_2 909663.KI867149_gene3211 5.04e-35 133.0 COG2230@1|root,COG2230@2|Bacteria,1MX3U@1224|Proteobacteria,42PB7@68525|delta/epsilon subdivisions,2WJX5@28221|Deltaproteobacteria,2MQHE@213462|Syntrophobacterales 28221|Deltaproteobacteria M PFAM Cyclopropane-fatty-acyl-phospholipid synthase - - 2.1.1.79 ko:K00574 - - - - ko00000,ko01000 - - - CMAS k59_127181_1 926550.CLDAP_24820 6.84e-25 103.0 COG0235@1|root,COG0235@2|Bacteria 2|Bacteria G Class ii aldolase - - 2.2.1.8,4.1.2.17,5.1.3.4 ko:K01628,ko:K03077,ko:K18847 ko00040,ko00051,ko00053,ko01100,ko01120,map00040,map00051,map00053,map01100,map01120 M00550 R02262,R05850 RC00603,RC00604,RC01479 ko00000,ko00001,ko00002,ko01000 - - - Aldolase_II k59_1483596_1 1297569.MESS2_p100001 5.05e-36 137.0 COG1181@1|root,COG1181@2|Bacteria,1R4RC@1224|Proteobacteria,2U0HF@28211|Alphaproteobacteria 28211|Alphaproteobacteria M ATP-grasp domain - - - - - - - - - - - - ATP-grasp_4 k59_1313756_1 309807.SRU_0188 1.48e-06 56.6 COG3547@1|root,COG3547@2|Bacteria,4NF2F@976|Bacteroidetes 976|Bacteroidetes L Transposase is116 is110 is902 family - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_71069_1 158500.BV97_00574 3.5e-97 290.0 COG0492@1|root,COG0492@2|Bacteria,1MV15@1224|Proteobacteria,2TRBW@28211|Alphaproteobacteria,2K0I2@204457|Sphingomonadales 204457|Sphingomonadales C Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family trxB - 1.8.1.9 ko:K00384 ko00450,map00450 - R02016,R03596,R09372 RC00013,RC02518,RC02873 ko00000,ko00001,ko01000 - - - Pyr_redox_2 k59_521701_1 296591.Bpro_2199 1.99e-79 248.0 COG0654@1|root,COG0654@2|Bacteria,1MXEW@1224|Proteobacteria,2VIVN@28216|Betaproteobacteria,4AC5F@80864|Comamonadaceae 28216|Betaproteobacteria C PFAM monooxygenase FAD-binding - - 1.14.13.218 ko:K20940 ko00405,ko01130,map00405,map01130 M00835 - - ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_3 k59_1425879_1 1298608.JCM18900_11279 1.45e-07 55.8 COG1075@1|root,COG1075@2|Bacteria,1NYAK@1224|Proteobacteria,1RZ8D@1236|Gammaproteobacteria,3NIGP@468|Moraxellaceae 1236|Gammaproteobacteria S Alpha beta hydrolase - - - - - - - - - - - - Abhydrolase_6,DUF676,PGAP1 k59_1425879_2 204669.Acid345_2074 3.37e-43 154.0 28HK0@1|root,2Z7V0@2|Bacteria,3Y7ZW@57723|Acidobacteria 57723|Acidobacteria S Domain of unknown function (DUF4105) - - - - - - - - - - - - DUF4105 k59_1765065_1 1379270.AUXF01000002_gene1345 1.37e-32 132.0 COG0412@1|root,COG0515@1|root,COG1262@1|root,COG0412@2|Bacteria,COG0515@2|Bacteria,COG1262@2|Bacteria,1ZUNU@142182|Gemmatimonadetes 142182|Gemmatimonadetes KLT Serine/Threonine protein kinases, catalytic domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase k59_353357_1 203122.Sde_2353 3.44e-281 785.0 COG3383@1|root,COG3383@2|Bacteria,1QX06@1224|Proteobacteria 1224|Proteobacteria C Molybdopterin oxidoreductase Fe4S4 domain - - - - - - - - - - - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding k59_1425881_1 264198.Reut_A2790 1.42e-100 306.0 COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,2VH8M@28216|Betaproteobacteria,1K0Q5@119060|Burkholderiaceae 28216|Betaproteobacteria C PFAM FAD linked oxidase domain protein glcD - 1.1.2.4,1.1.3.15,1.1.5.12 ko:K00102,ko:K00104,ko:K03777 ko00620,ko00630,ko01100,ko01110,ko01120,ko01130,map00620,map00630,map01100,map01110,map01120,map01130 - R00197,R00475,R00704,R11591 RC00042,RC00044 ko00000,ko00001,ko01000 - - - FAD-oxidase_C,FAD_binding_4 k59_1256629_1 1229909.NSED_05715 2e-216 600.0 COG3243@1|root,arCOG06344@2157|Archaea,41SEX@651137|Thaumarchaeota 651137|Thaumarchaeota I TIGRFAM poly(R)-hydroxyalkanoic acid synthase, class III, PhaC subunit - - - ko:K03821 ko00650,map00650 - R04254 RC00004 ko00000,ko00001,ko01000 - - - Abhydrolase_1 k59_1256629_2 436308.Nmar_0992 7.22e-73 221.0 arCOG08754@1|root,arCOG08754@2157|Archaea,41SUV@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1256629_3 436308.Nmar_0993 6.71e-73 221.0 arCOG03937@1|root,arCOG03937@2157|Archaea,41SWM@651137|Thaumarchaeota 651137|Thaumarchaeota K COG2002 Regulators of stationary sporulation gene expression - - - - - - - - - - - - - k59_1144120_1 70601.3256535 1.13e-09 64.3 COG2074@1|root,arCOG01967@2157|Archaea,2XVZC@28890|Euryarchaeota,242Y8@183968|Thermococci 183968|Thermococci F 2-phosphoglycerate kinase pgk2 - - ko:K05715 - - R02664 RC00002,RC00017 ko00000,ko01000 - - - ATP-cone k59_974038_1 983917.RGE_30930 2.25e-24 102.0 COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2VHK8@28216|Betaproteobacteria,1KN4H@119065|unclassified Burkholderiales 28216|Betaproteobacteria S Tripartite tricarboxylate transporter family receptor - - - - - - - - - - - - TctC k59_1484243_1 400682.PAC_15721659 8.55e-122 384.0 COG0060@1|root,KOG0434@2759|Eukaryota,38CIS@33154|Opisthokonta,3BA51@33208|Metazoa 33208|Metazoa J isoleucyl-tRNA aminoacylation IARS GO:0003674,GO:0003824,GO:0004812,GO:0004822,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006428,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017101,GO:0019538,GO:0019752,GO:0019899,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051020,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.5 ko:K01870 ko00970,map00970 M00359,M00360 R03656 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,tRNA-synt_1 k59_127921_1 536227.CcarbDRAFT_0621 2.07e-22 90.5 COG5010@1|root,COG5010@2|Bacteria,1VB7U@1239|Firmicutes,24BDJ@186801|Clostridia 186801|Clostridia U COG0457 FOG TPR repeat - - - - - - - - - - - - SMI1_KNR4 k59_1709148_1 1038859.AXAU01000009_gene1574 1.14e-26 112.0 28KKP@1|root,2ZA5F@2|Bacteria,1PCB9@1224|Proteobacteria,2U1AW@28211|Alphaproteobacteria,3JX5Y@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_1370898_1 88036.EFJ15233 5.33e-43 151.0 28NCX@1|root,2QUYC@2759|Eukaryota,37HJB@33090|Viridiplantae,3GD8N@35493|Streptophyta 35493|Streptophyta S Glutathione S-transferase, N-terminal domain - - - - - - - - - - - - GST_N_3 k59_918391_2 269799.Gmet_0035 8.71e-09 58.5 COG1639@1|root,COG1639@2|Bacteria,1RCW6@1224|Proteobacteria,43AIV@68525|delta/epsilon subdivisions,2X5Z4@28221|Deltaproteobacteria 28221|Deltaproteobacteria T Metal-dependent phosphohydrolase, HDOD domain-containing - - - - - - - - - - - - HDOD k59_862996_1 247634.GPB2148_15 4.13e-87 275.0 COG2303@1|root,COG2303@2|Bacteria,1MU3F@1224|Proteobacteria,1RPBQ@1236|Gammaproteobacteria,1J5ZV@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E COG2303 Choline dehydrogenase and related flavoproteins neoG - - - - - - - - - - - FAD_binding_2,GMC_oxred_C,GMC_oxred_N,NAD_binding_8 k59_522385_1 795666.MW7_2309 1.02e-46 153.0 COG1765@1|root,COG1765@2|Bacteria,1RCZW@1224|Proteobacteria,2VR62@28216|Betaproteobacteria,1K70K@119060|Burkholderiaceae 28216|Betaproteobacteria O PFAM OsmC family protein yhfA - - ko:K07397 - - - - ko00000 - - - OsmC k59_1032188_1 580332.Slit_0433 1.69e-121 358.0 COG1493@1|root,COG1493@2|Bacteria,1NNN5@1224|Proteobacteria,2VJCH@28216|Betaproteobacteria,44V87@713636|Nitrosomonadales 28216|Betaproteobacteria H Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr) hprK - - ko:K06023 - - - - ko00000,ko01000 - - - Hpr_kinase_C,Hpr_kinase_N k59_1709173_1 1229909.NSED_05590 1.2e-13 70.1 arCOG03622@1|root,arCOG03622@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_1653222_1 1415780.JPOG01000001_gene2382 5.95e-67 228.0 COG3827@1|root,COG3827@2|Bacteria,1QQR0@1224|Proteobacteria,1S068@1236|Gammaproteobacteria,1X3QQ@135614|Xanthomonadales 135614|Xanthomonadales - - - - - - - - - - - - - - - k59_863006_1 1287116.X734_11145 2.91e-44 155.0 COG0697@1|root,COG0697@2|Bacteria,1MV7Y@1224|Proteobacteria,2TUVM@28211|Alphaproteobacteria,43JJG@69277|Phyllobacteriaceae 28211|Alphaproteobacteria EG EamA-like transporter family - - - - - - - - - - - - EamA k59_71841_1 555793.WSK_2967 3.39e-31 121.0 COG0845@1|root,COG0845@2|Bacteria,1MU8D@1224|Proteobacteria,2TV4H@28211|Alphaproteobacteria,2K9M4@204457|Sphingomonadales 204457|Sphingomonadales M Biotin-lipoyl like - - - ko:K13888 - M00709 - - ko00000,ko00002,ko02000 8.A.1 - - HlyD_D23 k59_71841_2 522373.Smlt1538 1.3e-51 180.0 COG0577@1|root,COG1136@1|root,COG0577@2|Bacteria,COG1136@2|Bacteria,1MU45@1224|Proteobacteria,1RNUJ@1236|Gammaproteobacteria,1XD96@135614|Xanthomonadales 135614|Xanthomonadales V Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides macB - - ko:K05685 ko02010,map02010 M00709 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.122.1,3.A.1.122.12 - - ABC_tran,FtsX,MacB_PCD k59_1257259_1 404589.Anae109_1263 3.84e-66 223.0 COG0008@1|root,COG0064@1|root,COG0008@2|Bacteria,COG0064@2|Bacteria,1MUC8@1224|Proteobacteria,42MAX@68525|delta/epsilon subdivisions,2WJ5B@28221|Deltaproteobacteria,2YUA8@29|Myxococcales 28221|Deltaproteobacteria J glutaminyl-tRNA glnS - 6.1.1.18 ko:K01886 ko00970,ko01100,map00970,map01100 M00359,M00360 R03652 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - GatB_Yqey,tRNA-synt_1c,tRNA-synt_1c_C k59_748642_1 314278.NB231_11524 1.76e-42 152.0 COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,1RMFF@1236|Gammaproteobacteria,1X0AC@135613|Chromatiales 135613|Chromatiales C dihydrolipoamide dehydrogenase - - 1.8.1.4 ko:K00382 ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00036,M00307,M00532 R00209,R01221,R01698,R03815,R07618,R08549 RC00004,RC00022,RC00583,RC02742,RC02833,RC02834 br01601,ko00000,ko00001,ko00002,ko01000,ko04147 - - - Pyr_redox_2,Pyr_redox_dim k59_748642_2 1034943.BN1094_00145 1.31e-07 52.8 COG0045@1|root,COG0045@2|Bacteria,1MVCE@1224|Proteobacteria,1RMSU@1236|Gammaproteobacteria,1JCPV@118969|Legionellales 118969|Legionellales F Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit sucC - 6.2.1.5 ko:K01903 ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374,M00620 R00405,R02404 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000 - - - ATP-grasp_2,Ligase_CoA k59_635896_1 316407.85676317 2.91e-119 352.0 COG2723@1|root,COG2723@2|Bacteria,1MWG6@1224|Proteobacteria,1RMM2@1236|Gammaproteobacteria,3XNCY@561|Escherichia 1236|Gammaproteobacteria G Catalyzes the hydrolysis of phosphorylated beta- glucosides into glucose-6-phosphate (G-6-P) and aglycone. It has a high affinity for phosphorylated aromatic beta-glucosides (p- nitrophenyl-beta-glucoside, phenyl beta-glucoside, arbutin and phosphorylated salicin), and a low affinity for phosphorylated beta-methyl-glucoside bglB GO:0003674,GO:0003824,GO:0004553,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005984,GO:0008150,GO:0008152,GO:0008422,GO:0008706,GO:0009056,GO:0009311,GO:0009313,GO:0009987,GO:0015926,GO:0016052,GO:0016787,GO:0016798,GO:0044237,GO:0044238,GO:0044248,GO:0044262,GO:0044275,GO:0044424,GO:0044444,GO:0044464,GO:0046352,GO:0071704,GO:1901135,GO:1901575,GO:1901657,GO:2000891,GO:2000892 3.2.1.21,3.2.1.86 ko:K01223,ko:K05350 ko00010,ko00460,ko00500,ko00940,ko01100,ko01110,map00010,map00460,map00500,map00940,map01100,map01110 - R00026,R00839,R02558,R02887,R02985,R03527,R04949,R04998,R05133,R05134,R10035,R10039,R10040 RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248 ko00000,ko00001,ko01000 - GT1 iSSON_1240.SSON_3054 Glyco_hydro_1 k59_184301_1 1137799.GZ78_20200 7.75e-23 98.6 COG0130@1|root,COG0130@2|Bacteria,1MV0N@1224|Proteobacteria,1RMKP@1236|Gammaproteobacteria,1XH40@135619|Oceanospirillales 135619|Oceanospirillales J Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs truB - 5.4.99.25 ko:K03177 - - - - ko00000,ko01000,ko03016 - - - TruB-C_2,TruB_C_2,TruB_N k59_1087797_1 1532557.JL37_17925 1.9e-29 114.0 COG4974@1|root,COG4974@2|Bacteria,1MVNF@1224|Proteobacteria,2VIHD@28216|Betaproteobacteria,3T1RX@506|Alcaligenaceae 28216|Betaproteobacteria D recombinase XerD xerD - - ko:K04763 - - - - ko00000,ko03036 - - - Phage_int_SAM_1,Phage_integrase k59_748651_2 555793.WSK_3891 3.52e-65 204.0 COG0491@1|root,COG0491@2|Bacteria,1MU8Q@1224|Proteobacteria,2TSVS@28211|Alphaproteobacteria,2K0DY@204457|Sphingomonadales 204457|Sphingomonadales S Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid gloB - 3.1.2.6 ko:K01069 ko00620,map00620 - R01736 RC00004,RC00137 ko00000,ko00001,ko01000 - - - HAGH_C,Lactamase_B k59_1314465_1 1121479.AUBS01000037_gene2963 7.4e-59 196.0 COG0161@1|root,COG0161@2|Bacteria,1MU2N@1224|Proteobacteria,2TQND@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family - - - - - - - - - - - - Aminotran_3 k59_1314465_2 1282876.BAOK01000001_gene1378 1.05e-39 140.0 COG0824@1|root,COG0824@2|Bacteria,1MZB3@1224|Proteobacteria,2U7CU@28211|Alphaproteobacteria,4BS6R@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria S Thioesterase-like superfamily - - - ko:K07107 - - - - ko00000,ko01000 - - - 4HBT_2 k59_1032228_1 1079986.JH164869_gene3495 4.82e-26 99.8 COG2050@1|root,COG2050@2|Bacteria,2IQXX@201174|Actinobacteria 201174|Actinobacteria Q Thioesterase superfamily - - - - - - - - - - - - 4HBT k59_748661_1 436308.Nmar_0685 3.39e-87 262.0 COG0561@1|root,arCOG01213@2157|Archaea,41SIV@651137|Thaumarchaeota 651137|Thaumarchaeota S Phosphoglycolate phosphatase - - 3.1.3.18 ko:K22223 ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130 - R01334 RC00017 ko00000,ko00001,ko01000 - - - Hydrolase_3 k59_869243_1 1190606.AJYG01000192_gene2863 6.68e-48 170.0 COG3608@1|root,COG3608@2|Bacteria,1R784@1224|Proteobacteria,1RRY6@1236|Gammaproteobacteria,1Y0D5@135623|Vibrionales 135623|Vibrionales S Succinylglutamate desuccinylase / Aspartoacylase family - - - - - - - - - - - - AstE_AspA k59_360651_1 1206729.BAFZ01000159_gene6411 5.67e-77 239.0 COG1028@1|root,COG1028@2|Bacteria,2HAYI@201174|Actinobacteria,4FYAT@85025|Nocardiaceae 201174|Actinobacteria IQ Enoyl-(Acyl carrier protein) reductase - - - - - - - - - - - - adh_short_C2 k59_979968_1 1123368.AUIS01000005_gene471 2.9e-30 107.0 COG0254@1|root,COG0254@2|Bacteria,1MZ69@1224|Proteobacteria,1SCMH@1236|Gammaproteobacteria,2ND6J@225057|Acidithiobacillales 225057|Acidithiobacillales J Binds the 23S rRNA rpmE - - ko:K02909 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L31 k59_979968_2 1094563.MCQ_00423 2.72e-24 100.0 COG0372@1|root,COG0372@2|Bacteria,1MUKX@1224|Proteobacteria,2TS63@28211|Alphaproteobacteria,48TNR@772|Bartonellaceae 28211|Alphaproteobacteria C citrate (Si)-synthase activity gltA - 2.3.3.1 ko:K01647 ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00740 R00351 RC00004,RC00067 br01601,ko00000,ko00001,ko00002,ko01000 - - - Citrate_synt k59_1490434_1 391624.OIHEL45_18161 2.51e-54 185.0 COG3673@1|root,COG3673@2|Bacteria,1P8C1@1224|Proteobacteria,2U2EK@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Uncharacterized alpha/beta hydrolase domain (DUF2235) - - - - - - - - - - - - DUF2235 k59_21111_2 1122179.KB890480_gene3084 4.48e-60 203.0 COG0318@1|root,COG0318@2|Bacteria,4NFPF@976|Bacteroidetes 976|Bacteroidetes IQ Acyl-CoA synthetase (AMP-forming) AMP-acid ligase II - - - ko:K00666 - - - - ko00000,ko01000,ko01004 - - - AMP-binding,AMP-binding_C k59_585635_1 1192759.AKIB01000003_gene715 2.75e-38 138.0 COG1802@1|root,COG1802@2|Bacteria,1Q85H@1224|Proteobacteria,2VEVM@28211|Alphaproteobacteria,2K659@204457|Sphingomonadales 204457|Sphingomonadales K FCD - - - - - - - - - - - - FCD,GntR k59_78454_2 1122137.AQXF01000001_gene2873 3.18e-111 323.0 COG0500@1|root,COG2226@2|Bacteria,1MVSY@1224|Proteobacteria,2TTNQ@28211|Alphaproteobacteria 28211|Alphaproteobacteria Q methionine biosynthesis protein (MetW) metW - - - - - - - - - - - MetW k59_78454_3 1122137.AQXF01000001_gene2872 3.17e-44 153.0 COG2021@1|root,COG2021@2|Bacteria,1MVJV@1224|Proteobacteria,2TQYA@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine metXA GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004414,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008374,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009086,GO:0009092,GO:0009987,GO:0016053,GO:0016407,GO:0016413,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.3.1.31 ko:K00641 ko00270,ko01100,ko01130,map00270,map01100,map01130 - R01776 RC00004,RC00041 ko00000,ko00001,ko01000 - - - Abhydrolase_1 k59_1038954_1 713586.KB900536_gene365 3.78e-96 298.0 COG0608@1|root,COG0608@2|Bacteria,1MU1M@1224|Proteobacteria,1RMF4@1236|Gammaproteobacteria,1WW9D@135613|Chromatiales 135613|Chromatiales L single-stranded-DNA-specific exonuclease RecJ - - - ko:K07462 ko03410,ko03430,ko03440,map03410,map03430,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DHH,DHHA1 k59_1093796_1 1197477.IA57_10055 2.32e-42 147.0 COG3209@1|root,COG3209@2|Bacteria,4NNQE@976|Bacteroidetes,1I2G4@117743|Flavobacteriia 976|Bacteroidetes M COG3209 Rhs family protein - - - - - - - - - - - - - k59_416068_1 187303.BN69_2702 1.61e-33 129.0 COG2271@1|root,COG2271@2|Bacteria,1MXUC@1224|Proteobacteria 1224|Proteobacteria G Major facilitator Superfamily - - - - - - - - - - - - MFS_1 k59_78459_1 330214.NIDE4318 6.32e-66 225.0 COG1197@1|root,COG1197@2|Bacteria,3J0BA@40117|Nitrospirae 40117|Nitrospirae L Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site mfd - - ko:K03723 ko03420,map03420 - - - ko00000,ko00001,ko01000,ko03400 - - - CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF k59_21120_1 1096930.L284_08490 2.55e-51 171.0 COG0438@1|root,COG0438@2|Bacteria,1MUB7@1224|Proteobacteria,2TQQ0@28211|Alphaproteobacteria,2K08Y@204457|Sphingomonadales 204457|Sphingomonadales M glycosyl transferase group 1 - - - - - - - - - - - - Glyco_trans_1_4,Glyco_transf_4 k59_21120_2 158500.BV97_03415 2.13e-50 168.0 COG2908@1|root,COG2908@2|Bacteria,1MVKD@1224|Proteobacteria,2TSEB@28211|Alphaproteobacteria,2K0Q8@204457|Sphingomonadales 204457|Sphingomonadales S protein conserved in bacteria - - - - - - - - - - - - Metallophos,Metallophos_2 k59_1432581_1 1056820.KB900685_gene2828 1.28e-121 367.0 COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,1RNJI@1236|Gammaproteobacteria,2PMP7@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria L UvrD-like helicase C-terminal domain rep GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006268,GO:0006725,GO:0006807,GO:0006996,GO:0007049,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009628,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022402,GO:0032392,GO:0032508,GO:0034641,GO:0034645,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044786,GO:0044787,GO:0046483,GO:0050896,GO:0051276,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360,GO:1901576 3.6.4.12 ko:K03656,ko:K03657 ko03420,ko03430,map03420,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - UvrD-helicase,UvrD_C k59_1150469_1 1123367.C666_14890 7.26e-88 271.0 COG0124@1|root,COG0124@2|Bacteria,1MV2K@1224|Proteobacteria,2VIGA@28216|Betaproteobacteria,2KUKY@206389|Rhodocyclales 206389|Rhodocyclales J histidyl-tRNA synthetase hisS - 6.1.1.21 ko:K01892 ko00970,map00970 M00359,M00360 R03655 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,tRNA-synt_His k59_1093807_1 1292034.OR37_01874 2.8e-48 175.0 COG1629@1|root,COG1629@2|Bacteria,COG4771@2|Bacteria,1MUWN@1224|Proteobacteria,2TUIR@28211|Alphaproteobacteria 28211|Alphaproteobacteria P COG1629 Outer membrane receptor proteins, mostly Fe transport - - - - - - - - - - - - Plug,TonB_dep_Rec k59_246568_1 298655.KI912266_gene4438 2.57e-43 149.0 COG2030@1|root,COG2030@2|Bacteria,2GR2Y@201174|Actinobacteria 201174|Actinobacteria I N-terminal half of MaoC dehydratase - - - - - - - - - - - - MaoC_dehydrat_N k59_246568_2 686340.Metal_1980 1.81e-93 293.0 COG2304@1|root,COG2304@2|Bacteria,1N2UU@1224|Proteobacteria,1RXGJ@1236|Gammaproteobacteria,1XG8M@135618|Methylococcales 135618|Methylococcales S von Willebrand factor (vWF) type A domain - - - - - - - - - - - - VWA_2 k59_1320242_1 999541.bgla_1g28910 1.24e-92 280.0 COG0667@1|root,COG0667@2|Bacteria,1MU1S@1224|Proteobacteria,2VMYU@28216|Betaproteobacteria,1K2AM@119060|Burkholderiaceae 28216|Betaproteobacteria C aldo keto reductase - - - ko:K19265 - - - - ko00000,ko01000 - - - Aldo_ket_red k59_585660_1 377629.TERTU_3852 1.58e-44 150.0 COG1825@1|root,COG1825@2|Bacteria,1RDH0@1224|Proteobacteria,1S46A@1236|Gammaproteobacteria,2PN57@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria J Ribosomal L25p family ctc GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02897 ko03010,map03010 M00178 - - ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L25p,Ribosomal_TL5_C k59_585660_2 1415778.JQMM01000001_gene274 2.72e-14 71.6 COG0462@1|root,COG0462@2|Bacteria,1MW21@1224|Proteobacteria,1RMUC@1236|Gammaproteobacteria,1J4D2@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria F Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) prs GO:0000287,GO:0003674,GO:0003824,GO:0004749,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006015,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016772,GO:0016778,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0042301,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046391,GO:0046483,GO:0046872,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.6.1 ko:K00948 ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230 M00005 R01049 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - iAF1260.b1207,iAPECO1_1312.APECO1_323,iB21_1397.B21_01192,iBWG_1329.BWG_1032,iE2348C_1286.E2348C_1330,iEC042_1314.EC042_1264,iEC55989_1330.EC55989_1303,iECABU_c1320.ECABU_c14780,iECBD_1354.ECBD_2414,iECB_1328.ECB_01182,iECDH10B_1368.ECDH10B_1260,iECDH1ME8569_1439.ECDH1ME8569_1146,iECD_1391.ECD_01182,iECED1_1282.ECED1_1355,iECH74115_1262.ECH74115_1688,iECIAI1_1343.ECIAI1_1228,iECIAI39_1322.ECIAI39_1543,iECNA114_1301.ECNA114_1372,iECO103_1326.ECO103_1309,iECO111_1330.ECO111_1536,iECO26_1355.ECO26_1720,iECOK1_1307.ECOK1_1360,iECP_1309.ECP_1255,iECS88_1305.ECS88_1275,iECSE_1348.ECSE_1257,iECSF_1327.ECSF_1183,iECSP_1301.ECSP_1597,iECUMN_1333.ECUMN_1504,iECW_1372.ECW_m1293,iECs_1301.ECs1712,iEKO11_1354.EKO11_2647,iETEC_1333.ETEC_1311,iEcDH1_1363.EcDH1_2440,iEcE24377_1341.EcE24377A_1355,iEcHS_1320.EcHS_A1312,iEcSMS35_1347.EcSMS35_1935,iEcolC_1368.EcolC_2419,iG2583_1286.G2583_1478,iJO1366.b1207,iJR904.b1207,iLF82_1304.LF82_1744,iNRG857_1313.NRG857_06180,iSBO_1134.SBO_1860,iSDY_1059.SDY_1256,iSSON_1240.SSON_1971,iUMN146_1321.UM146_11025,iUMNK88_1353.UMNK88_1523,iUTI89_1310.UTI89_C1401,iWFL_1372.ECW_m1293,iY75_1357.Y75_RS06300,ic_1306.c1665 Pribosyl_synth,Pribosyltran_N k59_1490467_1 1392490.JHZX01000001_gene2394 2.63e-84 260.0 COG0472@1|root,COG0472@2|Bacteria,4NE0T@976|Bacteroidetes,1HWY5@117743|Flavobacteriia 976|Bacteroidetes M First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan mraY - 2.7.8.13 ko:K01000 ko00550,ko01100,ko01502,map00550,map01100,map01502 - R05629,R05630 RC00002,RC02753 ko00000,ko00001,ko01000,ko01011 9.B.146 - - Glycos_transf_4,MraY_sig1 k59_1490467_2 745718.JADT01000002_gene2404 4.75e-11 62.0 COG0769@1|root,COG0769@2|Bacteria,4NE9W@976|Bacteroidetes,1HXA8@117743|Flavobacteriia 976|Bacteroidetes M Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan murE - 6.3.2.13 ko:K01928 ko00300,ko00550,map00300,map00550 - R02788 RC00064,RC00090 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_1207369_1 861299.J421_3981 3.49e-77 243.0 COG4972@1|root,COG4972@2|Bacteria,1ZSYA@142182|Gemmatimonadetes 142182|Gemmatimonadetes NU Type IV pilus assembly protein PilM; - - - ko:K02662 - - - - ko00000,ko02035,ko02044 - - - PilM_2 k59_1490479_2 314285.KT71_10157 8.43e-42 145.0 COG1077@1|root,COG1077@2|Bacteria,1MUMW@1224|Proteobacteria,1RN82@1236|Gammaproteobacteria,1J52U@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria D COG1077 Actin-like ATPase involved in cell morphogenesis mreB GO:0000003,GO:0000910,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005856,GO:0005886,GO:0007049,GO:0008150,GO:0008360,GO:0009987,GO:0016020,GO:0019954,GO:0022402,GO:0022414,GO:0022603,GO:0022604,GO:0031224,GO:0031226,GO:0032505,GO:0042802,GO:0043093,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0048519,GO:0048523,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0051301,GO:0051302,GO:0051782,GO:0051983,GO:0065007,GO:0065008,GO:0071944 - ko:K03569 - - - - ko00000,ko02048,ko03036,ko04812 1.A.33.1,9.B.157.1 - - MreB_Mbl k59_528150_1 1114959.SZMC14600_12575 2.44e-41 153.0 COG0787@1|root,COG0787@2|Bacteria,2GM2Y@201174|Actinobacteria,4E8GN@85010|Pseudonocardiales 201174|Actinobacteria M Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids alr - 5.1.1.1 ko:K01775 ko00473,ko01100,ko01502,map00473,map01100,map01502 - R00401 RC00285 ko00000,ko00001,ko01000,ko01011 - - - Ala_racemase_C,Ala_racemase_N k59_134075_1 1217718.ALOU01000048_gene3865 1.52e-10 65.5 COG1752@1|root,COG1752@2|Bacteria,1PIHH@1224|Proteobacteria,2VHKX@28216|Betaproteobacteria,1K1GW@119060|Burkholderiaceae 28216|Betaproteobacteria S Patatin-like phospholipase - - - ko:K07001 - - - - ko00000 - - - Patatin k59_1602867_1 319224.Sputcn32_0895 1.44e-102 313.0 COG3634@1|root,COG3634@2|Bacteria,1MUKD@1224|Proteobacteria,1RNC7@1236|Gammaproteobacteria,2QAD3@267890|Shewanellaceae 1236|Gammaproteobacteria C PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase ahpF GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0008785,GO:0009321,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0032991,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0050660,GO:0050662,GO:0055114,GO:0071949,GO:0097159,GO:1901265,GO:1901363,GO:1902494,GO:1990204 - ko:K03387 - - - - ko00000,ko01000 - - - Pyr_redox_2,Thioredoxin_3 k59_1659605_1 7955.ENSDARP00000087881 3.26e-44 155.0 COG1290@1|root,KOG4663@2759|Eukaryota,38FBZ@33154|Opisthokonta,3BCGI@33208|Metazoa,3CZ4H@33213|Bilateria,481QH@7711|Chordata,495PH@7742|Vertebrata,49W2E@7898|Actinopterygii 33208|Metazoa C Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis CYTB GO:0000003,GO:0001666,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0005746,GO:0005750,GO:0006091,GO:0006119,GO:0006122,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0006950,GO:0006970,GO:0006972,GO:0006979,GO:0007275,GO:0007276,GO:0007283,GO:0007584,GO:0008121,GO:0008150,GO:0008152,GO:0009055,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009266,GO:0009408,GO:0009605,GO:0009628,GO:0009636,GO:0009651,GO:0009719,GO:0009725,GO:0009987,GO:0009991,GO:0010033,GO:0010035,GO:0010038,GO:0010243,GO:0014070,GO:0015672,GO:0015980,GO:0015988,GO:0015990,GO:0016020,GO:0016021,GO:0016310,GO:0016491,GO:0016679,GO:0016681,GO:0017144,GO:0019637,GO:0019693,GO:0019866,GO:0019953,GO:0020037,GO:0022414,GO:0022900,GO:0022904,GO:0031090,GO:0031099,GO:0031100,GO:0031224,GO:0031300,GO:0031301,GO:0031304,GO:0031305,GO:0031667,GO:0031966,GO:0031967,GO:0031975,GO:0032501,GO:0032502,GO:0032504,GO:0032592,GO:0032991,GO:0033273,GO:0033590,GO:0033762,GO:0034220,GO:0034641,GO:0036293,GO:0036296,GO:0042221,GO:0042493,GO:0042538,GO:0042773,GO:0042775,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043434,GO:0044237,GO:0044238,GO:0044281,GO:0044422,GO:0044424,GO:0044425,GO:0044429,GO:0044444,GO:0044446,GO:0044455,GO:0044464,GO:0044703,GO:0044877,GO:0045275,GO:0045333,GO:0045471,GO:0046034,GO:0046483,GO:0046677,GO:0046686,GO:0046688,GO:0046689,GO:0046906,GO:0048037,GO:0048038,GO:0048039,GO:0048232,GO:0048513,GO:0048609,GO:0048731,GO:0048856,GO:0050896,GO:0051179,GO:0051234,GO:0051592,GO:0051704,GO:0055085,GO:0055086,GO:0055093,GO:0055114,GO:0070069,GO:0070469,GO:0070482,GO:0071704,GO:0072521,GO:0097159,GO:0097305,GO:0098573,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098798,GO:0098800,GO:0098803,GO:1901135,GO:1901360,GO:1901363,GO:1901564,GO:1901652,GO:1901698,GO:1901700,GO:1902494,GO:1902600,GO:1990204 - ko:K00412 ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016 M00151,M00152 - - ko00000,ko00001,ko00002,ko03029 - - - Cytochrom_B_C,Cytochrome_B k59_1659605_2 10090.ENSMUSP00000081003 6.18e-67 215.0 COG1290@1|root,KOG4663@2759|Eukaryota,38FBZ@33154|Opisthokonta,3BCGI@33208|Metazoa,3CZ4H@33213|Bilateria,481QH@7711|Chordata,495PH@7742|Vertebrata,3J77S@40674|Mammalia,35PAU@314146|Euarchontoglires,4Q87A@9989|Rodentia 33208|Metazoa C electron transport coupled proton transport CYTB GO:0000003,GO:0001666,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0005746,GO:0005750,GO:0006091,GO:0006119,GO:0006122,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0006950,GO:0006970,GO:0006972,GO:0006979,GO:0007275,GO:0007276,GO:0007283,GO:0007584,GO:0008121,GO:0008150,GO:0008152,GO:0009055,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009266,GO:0009408,GO:0009605,GO:0009628,GO:0009636,GO:0009651,GO:0009719,GO:0009725,GO:0009987,GO:0009991,GO:0010033,GO:0010035,GO:0010038,GO:0010243,GO:0014070,GO:0015672,GO:0015980,GO:0015988,GO:0015990,GO:0016020,GO:0016021,GO:0016310,GO:0016491,GO:0016679,GO:0016681,GO:0017144,GO:0019637,GO:0019693,GO:0019866,GO:0019953,GO:0020037,GO:0022414,GO:0022900,GO:0022904,GO:0031090,GO:0031099,GO:0031100,GO:0031224,GO:0031300,GO:0031301,GO:0031304,GO:0031305,GO:0031667,GO:0031966,GO:0031967,GO:0031975,GO:0032501,GO:0032502,GO:0032504,GO:0032592,GO:0032991,GO:0033273,GO:0033590,GO:0033762,GO:0034220,GO:0034641,GO:0036293,GO:0036296,GO:0042221,GO:0042493,GO:0042538,GO:0042773,GO:0042775,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043434,GO:0044237,GO:0044238,GO:0044281,GO:0044422,GO:0044424,GO:0044425,GO:0044429,GO:0044444,GO:0044446,GO:0044455,GO:0044464,GO:0044703,GO:0044877,GO:0045275,GO:0045333,GO:0045471,GO:0046034,GO:0046483,GO:0046677,GO:0046686,GO:0046688,GO:0046689,GO:0046906,GO:0048037,GO:0048038,GO:0048039,GO:0048232,GO:0048513,GO:0048609,GO:0048731,GO:0048856,GO:0050896,GO:0051179,GO:0051234,GO:0051592,GO:0051704,GO:0055085,GO:0055086,GO:0055093,GO:0055114,GO:0070069,GO:0070469,GO:0070482,GO:0071704,GO:0072521,GO:0097159,GO:0097305,GO:0098573,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098798,GO:0098800,GO:0098803,GO:1901135,GO:1901360,GO:1901363,GO:1901564,GO:1901652,GO:1901698,GO:1901700,GO:1902494,GO:1902600,GO:1990204 - ko:K00412 ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016 M00151,M00152 - - ko00000,ko00001,ko00002,ko03029 - - - Cytochrom_B_C,Cytochrome_B k59_1207379_1 1131553.JIBI01000002_gene1804 3.17e-77 246.0 COG2211@1|root,COG2211@2|Bacteria,1MWSH@1224|Proteobacteria,2VJEQ@28216|Betaproteobacteria,372MX@32003|Nitrosomonadales 28216|Betaproteobacteria G BT1 family - - - - - - - - - - - - BT1 k59_1602871_1 1167006.UWK_01911 2.81e-67 218.0 COG0699@1|root,COG0699@2|Bacteria,1MV59@1224|Proteobacteria,42MBS@68525|delta/epsilon subdivisions,2WJVE@28221|Deltaproteobacteria,2MJ8T@213118|Desulfobacterales 28221|Deltaproteobacteria S PFAM Dynamin family - - - - - - - - - - - - Dynamin_N k59_528156_1 392499.Swit_1856 1.31e-51 179.0 COG1545@1|root,COG3425@1|root,COG1545@2|Bacteria,COG3425@2|Bacteria,1QV6D@1224|Proteobacteria,2TTB1@28211|Alphaproteobacteria,2K2KH@204457|Sphingomonadales 204457|Sphingomonadales I DUF35 OB-fold domain, acyl-CoA-associated - - - - - - - - - - - - ACP_syn_III_C,OB_aCoA_assoc k59_1602882_1 1123228.AUIH01000006_gene2161 2.77e-56 190.0 COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,1RQTU@1236|Gammaproteobacteria,1XHNV@135619|Oceanospirillales 135619|Oceanospirillales C Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family - - - - - - - - - - - - Pyr_redox_2,Pyr_redox_dim,SNARE_assoc k59_1150510_1 404589.Anae109_0599 3.1e-36 130.0 COG0363@1|root,COG0363@2|Bacteria,1R5K6@1224|Proteobacteria 1224|Proteobacteria G 6-phosphogluconolactonase pgl - 2.7.1.12,3.1.1.31 ko:K00851,ko:K01057 ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200 M00004,M00006,M00008 R01737,R02035 RC00002,RC00017,RC00537 ko00000,ko00001,ko00002,ko01000 - - - Glucosamine_iso k59_755630_2 1122137.AQXF01000001_gene3140 1.08e-90 284.0 COG0154@1|root,COG0154@2|Bacteria,1MWRI@1224|Proteobacteria,2TTJU@28211|Alphaproteobacteria 28211|Alphaproteobacteria J COG0154 Asp-tRNAAsn Glu-tRNAGln amidotransferase A subunit and related amidases - - 3.5.1.4,6.3.5.6,6.3.5.7 ko:K01426,ko:K02433 ko00330,ko00360,ko00380,ko00627,ko00643,ko00970,ko01100,ko01120,map00330,map00360,map00380,map00627,map00643,map00970,map01100,map01120 - R02540,R03096,R03180,R03905,R03909,R04212,R05551,R05590 RC00010,RC00100,RC00950,RC01025 ko00000,ko00001,ko01000,ko03029 - - - Amidase k59_755631_1 1348583.ATLH01000013_gene3119 4.97e-47 172.0 COG0489@1|root,COG3206@1|root,COG0489@2|Bacteria,COG3206@2|Bacteria,4NEXU@976|Bacteroidetes,1HXKJ@117743|Flavobacteriia,1F833@104264|Cellulophaga 976|Bacteroidetes DM CobQ CobB MinD ParA nucleotide binding domain - - - - - - - - - - - - AAA_31,CbiA,GNVR,Wzz k59_361978_1 983917.RGE_22530 3.23e-06 50.8 COG1387@1|root,COG1387@2|Bacteria,1R4SE@1224|Proteobacteria,2WI8C@28216|Betaproteobacteria,1KN4S@119065|unclassified Burkholderiales 28216|Betaproteobacteria E Histidinol phosphatase and related hydrolases of the PHP family - - - - - - - - - - - - - k59_361978_2 1038862.KB893829_gene5061 8.09e-20 86.3 COG3751@1|root,COG3751@2|Bacteria,1PPKJ@1224|Proteobacteria,2V229@28211|Alphaproteobacteria,3JU8T@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria O Putative 2OG-Fe(II) oxygenase - - - - - - - - - - - - 2OG-FeII_Oxy_5 k59_1094791_1 1121930.AQXG01000001_gene1203 1.07e-40 153.0 COG0841@1|root,COG0841@2|Bacteria,4NGCI@976|Bacteroidetes 976|Bacteroidetes V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K03296 - - - - ko00000 2.A.6.2 - - ACR_tran k59_305371_1 1122137.AQXF01000009_gene11 2.63e-154 470.0 COG0085@1|root,COG0085@2|Bacteria,1MUC4@1224|Proteobacteria,2TS7S@28211|Alphaproteobacteria 28211|Alphaproteobacteria K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoB GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234 2.7.7.6 ko:K03043 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7 k59_247771_1 105425.BBPL01000038_gene2878 7.91e-07 60.1 COG2114@1|root,COG3899@1|root,COG2114@2|Bacteria,COG3899@2|Bacteria,2GJRI@201174|Actinobacteria,2NG13@228398|Streptacidiphilus 201174|Actinobacteria T Adenylyl- / guanylyl cyclase, catalytic domain - - - - - - - - - - - - AAA_16,DZR,Guanylate_cyc,TPR_12 k59_1263828_1 1049564.TevJSym_bc00300 1.47e-52 176.0 COG0409@1|root,COG0409@2|Bacteria,1MU1F@1224|Proteobacteria,1RRTQ@1236|Gammaproteobacteria,1J9VF@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O Hydrogenase formation hypA family hypD GO:0003674,GO:0005488,GO:0005506,GO:0006464,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0019538,GO:0036211,GO:0042165,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0046872,GO:0046914,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0051604,GO:0070025,GO:0071704,GO:1901564 - ko:K04654 - - - - ko00000 - - - HypD k59_1263828_2 396588.Tgr7_1274 7.44e-55 179.0 COG0378@1|root,COG0378@2|Bacteria,1MVBD@1224|Proteobacteria,1RN9Y@1236|Gammaproteobacteria,1WWGI@135613|Chromatiales 135613|Chromatiales KO TIGRFAM Hydrogenase accessory protein HypB - - - ko:K04652 - - - - ko00000,ko03110 - - - cobW k59_1321147_1 324057.Pjdr2_3966 2.96e-68 219.0 COG4586@1|root,COG4586@2|Bacteria,1TP1N@1239|Firmicutes,4H9NR@91061|Bacilli,26R39@186822|Paenibacillaceae 91061|Bacilli S ABC transporter, ATP-binding protein - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran,DUF4162 k59_1716974_1 1088721.NSU_1449 3.3e-39 139.0 COG0548@1|root,COG0548@2|Bacteria,1MU17@1224|Proteobacteria,2TQQS@28211|Alphaproteobacteria,2K107@204457|Sphingomonadales 204457|Sphingomonadales E Belongs to the acetylglutamate kinase family. ArgB subfamily argB - 2.7.2.8 ko:K00930 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028 R02649 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase k59_1716974_2 1122137.AQXF01000001_gene2894 9.72e-67 213.0 COG3714@1|root,COG3714@2|Bacteria 2|Bacteria S YhhN family - - - - - - - - - - - - YhhN k59_361995_1 344747.PM8797T_13987 7.77e-36 140.0 COG0457@1|root,COG2304@1|root,COG0457@2|Bacteria,COG2304@2|Bacteria,2IYZ1@203682|Planctomycetes 203682|Planctomycetes A von Willebrand factor, type A - - - ko:K07114 - - - - ko00000,ko02000 1.A.13.2.2,1.A.13.2.3 - - VWA,VWA_2 k59_1716980_1 547163.BN979_02929 6.63e-71 230.0 COG2159@1|root,COG2159@2|Bacteria,2GKAB@201174|Actinobacteria,233WT@1762|Mycobacteriaceae 201174|Actinobacteria S amidohydrolase - - - - - - - - - - - - Amidohydro_2 k59_812647_1 269800.Tfu_1372 2.3e-48 176.0 COG1316@1|root,COG1316@2|Bacteria,2GM55@201174|Actinobacteria,4EGQ2@85012|Streptosporangiales 201174|Actinobacteria K Cell envelope-related transcriptional attenuator domain - - - - - - - - - - - - LytR_cpsA_psr k59_305383_1 1122137.AQXF01000008_gene3444 2.59e-62 209.0 COG0845@1|root,COG0845@2|Bacteria,1MUI8@1224|Proteobacteria,2TSP0@28211|Alphaproteobacteria 28211|Alphaproteobacteria M Type I secretion membrane fusion protein, HlyD - - - - - - - - - - - - Biotin_lipoyl_2,HlyD_3 k59_22413_1 436308.Nmar_0347 1.41e-122 379.0 COG0085@1|root,arCOG01762@2157|Archaea,41SF5@651137|Thaumarchaeota 651137|Thaumarchaeota K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates - - 2.7.7.6 ko:K13798 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00184 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021 - - - RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_4,RNA_pol_Rpb2_5,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7 k59_1094809_1 713586.KB900536_gene618 9.93e-10 65.5 COG0398@1|root,COG0607@1|root,COG0398@2|Bacteria,COG0607@2|Bacteria,1MVF3@1224|Proteobacteria,1RSK1@1236|Gammaproteobacteria 1236|Gammaproteobacteria P SNARE associated Golgi protein ydjX GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - - - - - - - - - - Rhodanese,SNARE_assoc k59_1491795_1 404589.Anae109_2424 2.98e-64 223.0 COG0249@1|root,COG0249@2|Bacteria,1N9K4@1224|Proteobacteria,42ZN5@68525|delta/epsilon subdivisions,2WUW7@28221|Deltaproteobacteria,2YTSE@29|Myxococcales 28221|Deltaproteobacteria L ATPase domain of DNA mismatch repair MUTS family - - - - - - - - - - - - MutS_III,MutS_V k59_1040276_1 1192759.AKIB01000065_gene3394 6.61e-06 47.4 COG0477@1|root,COG2814@2|Bacteria,1MW19@1224|Proteobacteria,2TRJ1@28211|Alphaproteobacteria,2K0JH@204457|Sphingomonadales 204457|Sphingomonadales EGP Major facilitator superfamily - - - ko:K07552 - - - - ko00000,ko02000 2.A.1.2 - - MFS_1 k59_1040276_2 1331060.RLDS_25760 8.39e-30 112.0 COG3293@1|root,COG3293@2|Bacteria,1PVIT@1224|Proteobacteria,2U1DA@28211|Alphaproteobacteria,2K9D2@204457|Sphingomonadales 204457|Sphingomonadales L Putative transposase of IS4/5 family (DUF4096) - - - - - - - - - - - - DDE_Tnp_1,DUF4096 k59_362013_2 94122.Shewana3_2413 7.67e-81 265.0 COG0642@1|root,COG2205@2|Bacteria,1N17V@1224|Proteobacteria,1RNFK@1236|Gammaproteobacteria,2QABE@267890|Shewanellaceae 1236|Gammaproteobacteria T histidine kinase HAMP region domain protein - - 2.7.13.3 ko:K07641 ko02020,map02020 M00449 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA k59_305397_1 395493.BegalDRAFT_3365 1.68e-15 77.0 COG0232@1|root,COG0232@2|Bacteria,1MVQ2@1224|Proteobacteria,1RPVJ@1236|Gammaproteobacteria,460J2@72273|Thiotrichales 72273|Thiotrichales F Belongs to the dGTPase family. Type 2 subfamily dgt - 3.1.5.1 ko:K01129 ko00230,map00230 - R01856 RC00017 ko00000,ko00001,ko01000 - - - HD,HD_assoc k59_1208583_1 1279038.KB907337_gene519 9.9e-56 179.0 COG2818@1|root,COG2818@2|Bacteria,1R9X5@1224|Proteobacteria,2TUP5@28211|Alphaproteobacteria,2JQMB@204441|Rhodospirillales 204441|Rhodospirillales L COG2818 3-methyladenine DNA glycosylase - - 3.2.2.20 ko:K01246 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - Adenine_glyco k59_1094833_1 1449343.JQLQ01000002_gene907 1.73e-28 116.0 COG2133@1|root,COG2133@2|Bacteria,1TR38@1239|Firmicutes,4HBME@91061|Bacilli,27GU9@186828|Carnobacteriaceae 91061|Bacilli G Glucose / Sorbosone dehydrogenase - - - - - - - - - - - - CBM_6,GSDH,PKD,ThuA k59_362032_1 679197.HMPREF9336_00560 2.07e-49 174.0 COG0624@1|root,COG0624@2|Bacteria,2IDWD@201174|Actinobacteria 201174|Actinobacteria E Dipeptidase - - 3.5.1.18 ko:K01439 ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230 M00016 R02734 RC00064,RC00090 ko00000,ko00001,ko00002,ko01000 - - - Peptidase_M20 k59_473241_1 502025.Hoch_3514 3.32e-106 327.0 COG1022@1|root,COG1022@2|Bacteria,1MU4D@1224|Proteobacteria,42N2G@68525|delta/epsilon subdivisions,2WIXB@28221|Deltaproteobacteria,2YZ4W@29|Myxococcales 28221|Deltaproteobacteria I AMP-binding enzyme - - 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding k59_1717022_1 395494.Galf_1865 1.78e-63 220.0 COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,2VKIW@28216|Betaproteobacteria,44VAG@713636|Nitrosomonadales 28216|Betaproteobacteria I Acyl-CoA dehydrogenase, N-terminal domain fadE - - ko:K06445 ko00071,ko01100,ko01212,map00071,map01100,map01212 M00087 R01175,R01279,R03777,R03857,R03990,R04751,R04754 RC00052,RC00076 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N,DUF1974 k59_700144_1 2340.JV46_15600 6.46e-44 157.0 COG1565@1|root,COG1565@2|Bacteria,1N3CJ@1224|Proteobacteria,1RYCJ@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Putative S-adenosyl-L-methionine-dependent methyltransferase - - - - - - - - - - - - Methyltransf_28 k59_247822_1 1094184.KWO_0114705 5.31e-44 156.0 COG0121@1|root,COG0121@2|Bacteria,1Q80V@1224|Proteobacteria,1SN0H@1236|Gammaproteobacteria,1X58F@135614|Xanthomonadales 135614|Xanthomonadales S Phosphoinositide phospholipase C, Ca2+-dependent - - - - - - - - - - - - PI-PLC-C1 k59_473244_1 333138.LQ50_09340 3.74e-34 131.0 COG0657@1|root,COG0657@2|Bacteria,1TQHX@1239|Firmicutes,4HB91@91061|Bacilli,1ZB27@1386|Bacillus 91061|Bacilli I COG0657 Esterase lipase - - - ko:K01066 - - - - ko00000,ko01000 - - - Abhydrolase_3 k59_1208606_1 436308.Nmar_1509 9.58e-05 43.9 COG0608@1|root,arCOG00427@2157|Archaea,41SZF@651137|Thaumarchaeota 651137|Thaumarchaeota L DHHA1 domain - - - ko:K07463 - - - - ko00000 - - - DHHA1 k59_1208606_2 436308.Nmar_1510 1.27e-35 122.0 arCOG01354@1|root,arCOG01354@2157|Archaea,41T7T@651137|Thaumarchaeota 651137|Thaumarchaeota S Transcription factor Pcc1 - - - - - - - - - - - - Pcc1 k59_1208606_3 436308.Nmar_1511 2.2e-108 325.0 COG0172@1|root,arCOG00403@2157|Archaea,41SC9@651137|Thaumarchaeota 651137|Thaumarchaeota J Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) serS - 6.1.1.11 ko:K01875 ko00970,map00970 M00359,M00360 R03662,R08218 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Seryl_tRNA_N,tRNA-synt_2b k59_1717052_1 314287.GB2207_10633 3.02e-71 228.0 COG1109@1|root,COG1109@2|Bacteria,1MU24@1224|Proteobacteria,1RMR2@1236|Gammaproteobacteria,1J55X@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria G Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate glmM - 5.4.2.10 ko:K03431 ko00520,ko01100,ko01130,map00520,map01100,map01130 - R02060 RC00408 ko00000,ko00001,ko01000 - - - PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV k59_1717052_2 398527.Bphyt_2861 1.16e-09 58.9 COG0294@1|root,COG0294@2|Bacteria,1MUIR@1224|Proteobacteria,2VH2Q@28216|Betaproteobacteria,1K2R5@119060|Burkholderiaceae 28216|Betaproteobacteria H Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives folP - 2.5.1.15 ko:K00796 ko00790,ko01100,map00790,map01100 M00126,M00841 R03066,R03067 RC00121,RC00842 ko00000,ko00001,ko00002,ko01000 - - - Pterin_bind k59_1604270_1 1122137.AQXF01000002_gene343 8.11e-07 50.1 COG0739@1|root,COG0739@2|Bacteria,1MVTF@1224|Proteobacteria,2TQZE@28211|Alphaproteobacteria 28211|Alphaproteobacteria M COG0739 Membrane proteins related to metalloendopeptidases MA20_30780 - - - - - - - - - - - Peptidase_M23 k59_30696_1 1122137.AQXF01000002_gene424 1.14e-109 319.0 COG1309@1|root,COG1309@2|Bacteria,1R6X5@1224|Proteobacteria,2U7EK@28211|Alphaproteobacteria 28211|Alphaproteobacteria K transcriptional regulator - - - - - - - - - - - - TetR_N k59_423397_1 1121380.JNIW01000015_gene2664 6.85e-59 195.0 COG1960@1|root,COG1960@2|Bacteria 2|Bacteria I acyl-CoA dehydrogenase activity - - - ko:K06446 ko00930,ko01100,ko01120,map00930,map01100,map01120 - R06943 RC00052 ko00000,ko00001,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_1556795_1 1122137.AQXF01000003_gene2458 4.45e-86 263.0 COG0560@1|root,COG0560@2|Bacteria,1MWA3@1224|Proteobacteria,2TSEU@28211|Alphaproteobacteria 28211|Alphaproteobacteria E phosphoserine phosphatase serB - 3.1.3.3 ko:K01079 ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230 M00020 R00582 RC00017 ko00000,ko00001,ko00002,ko01000,ko01009 - - - HAD k59_1158646_1 1430440.MGMSRv2_0379 1.29e-71 223.0 COG0424@1|root,COG0424@2|Bacteria,1RH6H@1224|Proteobacteria,2TSS5@28211|Alphaproteobacteria,2JRPN@204441|Rhodospirillales 204441|Rhodospirillales D Maf-like protein maf - - ko:K06287 - - - - ko00000 - - - Maf k59_1158646_2 1122137.AQXF01000004_gene1786 2.02e-123 369.0 COG1530@1|root,COG1530@2|Bacteria,1MWBR@1224|Proteobacteria,2TU44@28211|Alphaproteobacteria 28211|Alphaproteobacteria J COG1530 Ribonucleases G and E rng - 3.1.26.12 ko:K08300,ko:K08301 ko03018,map03018 M00394 - - ko00000,ko00001,ko00002,ko01000,ko03009,ko03019 - - - RNase_E_G k59_761250_1 871585.BDGL_002954 2.9e-38 137.0 COG1651@1|root,COG1651@2|Bacteria,1RGWH@1224|Proteobacteria,1S5WA@1236|Gammaproteobacteria,3NJ0Z@468|Moraxellaceae 1236|Gammaproteobacteria O Thiol disulfide interchange protein dsbA - - ko:K03673 ko01503,map01503 M00728 - - ko00000,ko00001,ko00002,ko03110 - - - DSBA k59_1612002_1 1095769.CAHF01000014_gene3044 3e-06 48.5 COG0607@1|root,COG0607@2|Bacteria,1MZ83@1224|Proteobacteria,2VU3D@28216|Betaproteobacteria,474II@75682|Oxalobacteraceae 28216|Betaproteobacteria P Rhodanese Homology Domain glpE - 2.8.1.1,2.8.1.2 ko:K01011 ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122 - R01931,R03105,R03106 RC00214 ko00000,ko00001,ko01000 - - - Rhodanese k59_1612002_2 1396858.Q666_11355 1.32e-30 113.0 COG1952@1|root,COG1952@2|Bacteria,1RI75@1224|Proteobacteria,1S62H@1236|Gammaproteobacteria,4679N@72275|Alteromonadaceae 1236|Gammaproteobacteria U One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA secB GO:0002790,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006605,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0032940,GO:0033036,GO:0034613,GO:0042886,GO:0043952,GO:0044424,GO:0044444,GO:0044464,GO:0045184,GO:0046903,GO:0046907,GO:0051082,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0070727,GO:0071702,GO:0071705,GO:0071806,GO:0072321 - ko:K03071 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044,ko03110 3.A.5 - - SecB k59_878556_1 1123020.AUIE01000002_gene1649 8.57e-13 70.9 COG3346@1|root,COG3346@2|Bacteria,1MZUH@1224|Proteobacteria,1S8S0@1236|Gammaproteobacteria,1YFZU@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria S SURF1 family surf1 - - ko:K14998 - - - - ko00000,ko03029 3.D.4.8 - - SURF1 k59_423411_1 382464.ABSI01000021_gene423 4.1e-52 167.0 COG0440@1|root,COG0440@2|Bacteria,46SUP@74201|Verrucomicrobia,2IU7V@203494|Verrucomicrobiae 203494|Verrucomicrobiae E ACT domain - - 2.2.1.6 ko:K01653 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - ACT,ACT_5,ALS_ss_C k59_818228_2 1828.JOKB01000029_gene3772 5.7e-09 57.0 COG0366@1|root,COG0366@2|Bacteria,2GKS4@201174|Actinobacteria,4FUMW@85025|Nocardiaceae 201174|Actinobacteria G Alpha-amylase domain aglA - 3.2.1.20 ko:K01187 ko00052,ko00500,ko01100,map00052,map00500,map01100 - R00028,R00801,R00802,R06087,R06088 RC00028,RC00049,RC00077 ko00000,ko00001,ko01000 - GH31 - Alpha-amylase,DUF3459 k59_708126_1 1444711.CCJF01000005_gene372 4.48e-17 84.3 COG1266@1|root,COG1266@2|Bacteria 2|Bacteria V CAAX protease self-immunity - - - ko:K07052 - - - - ko00000 - - - Abi k59_370265_1 1122137.AQXF01000001_gene2698 1.06e-113 333.0 COG0483@1|root,COG0483@2|Bacteria,1PPJ0@1224|Proteobacteria,2TQTX@28211|Alphaproteobacteria 28211|Alphaproteobacteria G inositol mono-phosphatase hisN - 3.1.3.15,3.1.3.25,3.1.3.93 ko:K01092,ko:K18649 ko00053,ko00340,ko00521,ko00562,ko01100,ko01110,ko01230,ko04070,map00053,map00340,map00521,map00562,map01100,map01110,map01230,map04070 M00026,M00114,M00131 R01185,R01186,R01187,R03013,R07674 RC00017,RC00078 ko00000,ko00001,ko00002,ko01000 - - - Inositol_P k59_370265_2 1122137.AQXF01000001_gene2697 7.84e-80 249.0 COG0665@1|root,COG0665@2|Bacteria,1MY0G@1224|Proteobacteria,2TRM2@28211|Alphaproteobacteria 28211|Alphaproteobacteria E COG0665 Glycine D-amino acid oxidases (deaminating) - - 1.4.99.6 ko:K19746 ko00472,ko01100,map00472,map01100 - R11018 RC00006 ko00000,ko00001,ko01000 - - - DAO k59_1439356_1 290397.Adeh_1373 2.7e-55 187.0 COG2201@1|root,COG2201@2|Bacteria,1MWCN@1224|Proteobacteria,42M27@68525|delta/epsilon subdivisions,2WJ2S@28221|Deltaproteobacteria 28221|Deltaproteobacteria NT catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR cheB1 - 3.1.1.61,3.5.1.44 ko:K03412 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko02022,ko02035 - - - CheB_methylest,Response_reg k59_1666658_1 1265313.HRUBRA_00544 2.1e-05 45.8 COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,1RQUR@1236|Gammaproteobacteria,1J54K@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria F Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen nrdZ - 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - Intein_splicing,LAGLIDADG_3,Ribonuc_red_lgC,Ribonuc_red_lgN k59_1666658_2 1385935.N836_09965 7.56e-16 77.8 COG2909@1|root,COG2909@2|Bacteria,1G3UH@1117|Cyanobacteria,1HDU6@1150|Oscillatoriales 1117|Cyanobacteria K transcriptional regulator - - - ko:K03556 - - - - ko00000,ko03000 - - - GerE k59_1158675_1 1123401.JHYQ01000030_gene3064 9.55e-66 225.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,45ZPF@72273|Thiotrichales 72273|Thiotrichales V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_1499982_1 1229909.NSED_09020 2.96e-66 211.0 arCOG10599@1|root,arCOG10599@2157|Archaea 2157|Archaea C copper ion binding - - - - - - - - - - - - - k59_1049145_1 1144305.PMI02_03668 7.74e-30 114.0 COG2207@1|root,COG2207@2|Bacteria,1NJXT@1224|Proteobacteria,2UJAH@28211|Alphaproteobacteria,2K9C2@204457|Sphingomonadales 204457|Sphingomonadales K helix_turn_helix, arabinose operon control protein - - - - - - - - - - - - HTH_18 k59_479925_1 702113.PP1Y_Mpl8203 4.59e-20 92.8 COG4774@1|root,COG4774@2|Bacteria 2|Bacteria P siderophore transport - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_371645_1 1458427.BAWN01000015_gene998 1.33e-31 115.0 COG0732@1|root,COG0732@2|Bacteria,1RKBT@1224|Proteobacteria,2VTQE@28216|Betaproteobacteria 28216|Betaproteobacteria V type I restriction modification DNA specificity domain - - - - - - - - - - - - Methylase_S k59_1725649_1 319236.JCM19294_1288 1.51e-58 197.0 COG4147@1|root,COG4147@2|Bacteria,4NHPT@976|Bacteroidetes,1HXQN@117743|Flavobacteriia,3HJPB@363408|Nonlabens 976|Bacteroidetes S Sodium:solute symporter family actP - - ko:K14393 - - - - ko00000,ko02000 2.A.21.7 - - SSF k59_1725649_2 765914.ThisiDRAFT_0967 3.81e-34 120.0 COG4327@1|root,COG4327@2|Bacteria,1N0TK@1224|Proteobacteria,1S8V9@1236|Gammaproteobacteria,1WZ1D@135613|Chromatiales 135613|Chromatiales S solute sodium symporter, small subunit - - - - - - - - - - - - DUF4212 k59_709510_1 1254432.SCE1572_03720 6.6e-37 144.0 COG1858@1|root,COG3391@1|root,COG1858@2|Bacteria,COG3391@2|Bacteria,1R66T@1224|Proteobacteria 1224|Proteobacteria C amine dehydrogenase activity - - - - - - - - - - - - - k59_932124_1 994479.GL877878_gene412 7.05e-10 59.7 COG1191@1|root,COG1191@2|Bacteria,2GKBK@201174|Actinobacteria,4DZK1@85010|Pseudonocardiales 201174|Actinobacteria K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released whiG - - ko:K02405 ko02020,ko02025,ko02026,ko02040,ko05111,map02020,map02025,map02026,map02040,map05111 - - - ko00000,ko00001,ko02035,ko03021 - - - Sigma70_r2,Sigma70_r3,Sigma70_r4 k59_932124_2 981383.AEWH01000004_gene3413 1.9e-31 120.0 COG4974@1|root,COG4974@2|Bacteria,1TPQB@1239|Firmicutes,4HARA@91061|Bacilli 91061|Bacilli D Belongs to the 'phage' integrase family. XerC subfamily xerC - - ko:K03733,ko:K04763 - - - - ko00000,ko03036 - - - Phage_int_SAM_1,Phage_integrase k59_987876_1 1229909.NSED_06090 4.89e-155 444.0 COG5256@1|root,arCOG01561@2157|Archaea,41SD2@651137|Thaumarchaeota 651137|Thaumarchaeota J This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis tuf - - ko:K03231 ko03013,ko05134,map03013,map05134 - - - ko00000,ko00001,ko03012,ko03016,ko03019,ko04131,ko04147 - - - GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3 k59_987876_2 436308.Nmar_1033 9.7e-46 148.0 COG0051@1|root,arCOG01758@2157|Archaea,41SQB@651137|Thaumarchaeota 651137|Thaumarchaeota J Involved in the binding of tRNA to the ribosomes rps10 - - ko:K02946 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S10 k59_256950_1 631362.Thi970DRAFT_04509 3.42e-17 79.0 COG0457@1|root,COG0457@2|Bacteria,1R714@1224|Proteobacteria,1SA9Y@1236|Gammaproteobacteria,1WY64@135613|Chromatiales 135613|Chromatiales S Tetratricopeptide repeat - - - - - - - - - - - - - k59_256950_2 322710.Avin_01650 1.79e-23 96.7 COG1045@1|root,COG1045@2|Bacteria,1MVFX@1224|Proteobacteria,1RNCA@1236|Gammaproteobacteria 1236|Gammaproteobacteria E serine acetyltransferase cysE - 2.3.1.30 ko:K00640 ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111 M00021 R00586 RC00004,RC00041 ko00000,ko00001,ko00002,ko01000 - - - Hexapep,SATase_N k59_879995_1 1385935.N836_19800 2.21e-35 137.0 COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1145@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1145@2|Bacteria,1G2E2@1117|Cyanobacteria,1H7QT@1150|Oscillatoriales 1117|Cyanobacteria C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin nifJ GO:0003674,GO:0003824,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0016491,GO:0050896,GO:0055114 1.2.7.1 ko:K03737 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00173,M00307 R01196,R10866 RC00004,RC02742 br01601,ko00000,ko00001,ko00002,ko01000 - - iJN678.nifJ EKR,Fer4_16,PFOR_II,POR,POR_N,TPP_enzyme_C k59_424388_1 1313172.YM304_04000 8.89e-31 114.0 COG1143@1|root,COG1143@2|Bacteria,2H4NQ@201174|Actinobacteria 201174|Actinobacteria C 4Fe-4S dicluster domain - - - - - - - - - - - - Fer4,Fer4_10 k59_1667728_1 391625.PPSIR1_13430 1.23e-62 205.0 COG5587@1|root,COG5587@2|Bacteria,1R8B4@1224|Proteobacteria,42RKE@68525|delta/epsilon subdivisions,2WS0D@28221|Deltaproteobacteria 28221|Deltaproteobacteria S PFAM conserved - - - - - - - - - - - - DUF2461 k59_879998_1 1407650.BAUB01000003_gene965 3.61e-65 215.0 COG2304@1|root,COG2304@2|Bacteria,1G3PE@1117|Cyanobacteria,1H2SF@1129|Synechococcus 1117|Cyanobacteria S Domain of unknown function (DUF3520) - - - ko:K07114 - - - - ko00000,ko02000 1.A.13.2.2,1.A.13.2.3 - - DUF3520,VWA,vWF_A k59_1049197_1 551275.KB899547_gene539 1.39e-107 344.0 COG0457@1|root,COG0457@2|Bacteria,1N09H@1224|Proteobacteria,2TSKT@28211|Alphaproteobacteria,43X9V@69657|Hyphomonadaceae 28211|Alphaproteobacteria S Tetratricopeptide repeat - - - - - - - - - - - - - k59_256964_1 1379270.AUXF01000002_gene1290 8.67e-33 131.0 COG0515@1|root,COG0515@2|Bacteria,1ZUFG@142182|Gemmatimonadetes 142182|Gemmatimonadetes KLT Protein kinase domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase k59_1160029_1 3055.EDO99697 2.76e-16 80.9 COG1171@1|root,KOG1251@2759|Eukaryota,37NUI@33090|Viridiplantae,34JDG@3041|Chlorophyta 3041|Chlorophyta ET serine threonine dehydratase - - 5.1.1.18 ko:K12235 ko00260,ko01100,map00260,map01100 - R00589 RC00302 ko00000,ko00001,ko01000 - - - PALP k59_819643_1 316407.1651490 5.81e-120 343.0 COG3381@1|root,COG3381@2|Bacteria,1RJ3Z@1224|Proteobacteria,1S31G@1236|Gammaproteobacteria,3XNXG@561|Escherichia 1236|Gammaproteobacteria O Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor torD GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006807,GO:0008150,GO:0008152,GO:0010467,GO:0019538,GO:0033218,GO:0042277,GO:0042802,GO:0043170,GO:0043546,GO:0044238,GO:0044424,GO:0044464,GO:0048037,GO:0050662,GO:0051604,GO:0071704,GO:0097159,GO:1901363,GO:1901564 - ko:K03533 ko02020,map02020 - - - ko00000,ko00001,ko02000 5.A.3.4 - - Nitrate_red_del k59_32106_1 493475.GARC_4664 4.67e-86 277.0 COG1472@1|root,COG1472@2|Bacteria,1MVIV@1224|Proteobacteria,1RMA0@1236|Gammaproteobacteria,465BV@72275|Alteromonadaceae 1236|Gammaproteobacteria G Family 3 celD - 3.2.1.21 ko:K05349 ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110 - R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040 RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248 ko00000,ko00001,ko01000 - GH3 - Glyco_hydro_3,Glyco_hydro_3_C k59_424398_1 1005048.CFU_0519 8.86e-22 90.9 COG0106@1|root,COG0106@2|Bacteria,1MW6S@1224|Proteobacteria,2VI38@28216|Betaproteobacteria,472IS@75682|Oxalobacteraceae 28216|Betaproteobacteria E 1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase hisA GO:0000105,GO:0000162,GO:0003674,GO:0003824,GO:0003949,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.3.1.16 ko:K01814 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04640 RC00945 ko00000,ko00001,ko00002,ko01000 - - - His_biosynth k59_424398_2 1247726.MIM_c04870 1.36e-37 132.0 COG0118@1|root,COG0118@2|Bacteria,1MU4X@1224|Proteobacteria,2VJPI@28216|Betaproteobacteria,3T247@506|Alcaligenaceae 28216|Betaproteobacteria E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR hisH - - ko:K02501 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04558 RC00010,RC01190,RC01943 ko00000,ko00001,ko00002,ko01000 - - - GATase k59_1388221_1 1336208.JADY01000009_gene2521 1.09e-31 127.0 COG0668@1|root,COG0668@2|Bacteria,1MY0I@1224|Proteobacteria,2TSIN@28211|Alphaproteobacteria,2JPY4@204441|Rhodospirillales 204441|Rhodospirillales M Mechanosensitive ion channel - - - ko:K22044 - - - - ko00000,ko02000 1.A.23.3 - - MS_channel k59_535263_2 743719.PaelaDRAFT_5133 5.3e-33 124.0 COG2227@1|root,COG2227@2|Bacteria 2|Bacteria H 3-demethylubiquinone-9 3-O-methyltransferase activity - - - ko:K06219 - - - - ko00000 - - - Glycos_transf_1,Glycos_transf_2,MethyTransf_Reg,Methyltransf_11,Methyltransf_23,Methyltransf_25,Methyltransf_31,TPR_2 k59_1102048_1 1122137.AQXF01000004_gene1699 1.57e-111 334.0 COG0642@1|root,COG0642@2|Bacteria,1QYPP@1224|Proteobacteria,2TXUU@28211|Alphaproteobacteria 28211|Alphaproteobacteria T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c k59_1558366_1 1392490.JHZX01000001_gene3348 4.59e-46 158.0 COG1181@1|root,COG1181@2|Bacteria,4NGM6@976|Bacteroidetes,1I09J@117743|Flavobacteriia 976|Bacteroidetes M Belongs to the D-alanine--D-alanine ligase family - - - - - - - - - - - - ATP-grasp_4 k59_1558366_2 1492738.FEM21_30470 5.34e-30 117.0 COG0260@1|root,COG0260@2|Bacteria,4NDWT@976|Bacteroidetes,1HZZ2@117743|Flavobacteriia,2NTWI@237|Flavobacterium 976|Bacteroidetes E Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides pepA - 3.4.11.1 ko:K01255 ko00480,ko01100,map00480,map01100 - R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 - - - Peptidase_M17,Peptidase_M17_N k59_649795_1 1122604.JONR01000027_gene3049 3.14e-69 229.0 COG3180@1|root,COG3180@2|Bacteria,1MUFS@1224|Proteobacteria,1RPMJ@1236|Gammaproteobacteria,1X6NH@135614|Xanthomonadales 135614|Xanthomonadales S Transition state regulatory protein AbrB - - - ko:K07120 - - - - ko00000 - - - AbrB k59_1725687_1 1265505.ATUG01000003_gene673 4.58e-40 149.0 COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria,42MFK@68525|delta/epsilon subdivisions,2WKBU@28221|Deltaproteobacteria 28221|Deltaproteobacteria E extracellular solute-binding protein, family 5 - - - ko:K02035,ko:K13893 ko02010,ko02024,map02010,map02024 M00239,M00349 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5,3.A.1.5.21,3.A.1.5.24 - - SBP_bac_5 k59_199316_1 1524467.IV04_19695 6.34e-93 296.0 COG4231@1|root,COG4231@2|Bacteria,1MUKS@1224|Proteobacteria,1RSEQ@1236|Gammaproteobacteria 1236|Gammaproteobacteria C indolepyruvate ferredoxin oxidoreductase - - 1.2.7.8 ko:K00179 - - - - br01601,ko00000,ko01000 - - - Fer4,Fer4_10,POR_N,TPP_enzyme_C k59_1558370_1 1150600.ADIARSV_1362 3.23e-21 98.2 COG3291@1|root,COG3291@2|Bacteria,4NHAX@976|Bacteroidetes,1IRW7@117747|Sphingobacteriia 976|Bacteroidetes S Pkd domain containing protein - - - - - - - - - - - - CBM_4_9 k59_199320_1 1122604.JONR01000025_gene4555 2.93e-10 66.6 COG3170@1|root,COG3170@2|Bacteria,1MXV7@1224|Proteobacteria,1RMM5@1236|Gammaproteobacteria,1X4MQ@135614|Xanthomonadales 135614|Xanthomonadales NU Tfp pilus assembly protein FimV fimV - - ko:K08086 - - - - ko00000 - - - TPR_19 k59_257008_1 575540.Isop_0044 4.08e-83 273.0 COG0567@1|root,COG0567@2|Bacteria,2IWRF@203682|Planctomycetes 203682|Planctomycetes C Dehydrogenase E1 component sucA - 1.2.4.2 ko:K00164 ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00032 R00621,R01933,R01940,R03316,R08549 RC00004,RC00027,RC00627,RC02743,RC02833,RC02883 br01601,ko00000,ko00001,ko00002,ko01000 - - - 2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr k59_880050_1 4081.Solyc01g007640.2.1 9.99e-67 231.0 2CMQD@1|root,2QRDV@2759|Eukaryota,37QIN@33090|Viridiplantae,3GEA1@35493|Streptophyta,44PKI@71274|asterids 35493|Streptophyta C Plant protein of unknown function (DUF825) - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0009507,GO:0009509,GO:0009532,GO:0009536,GO:0009570,GO:0009575,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464 - - - - - - - - - - AAA,DUF825 k59_709585_1 1096930.L284_11315 3.85e-54 176.0 2B20I@1|root,31UH7@2|Bacteria,1NA6V@1224|Proteobacteria,2UIZX@28211|Alphaproteobacteria,2K771@204457|Sphingomonadales 204457|Sphingomonadales - - - - - - - - - - - - - - - k59_709585_2 1144305.PMI02_01726 1.57e-15 74.7 COG0117@1|root,COG1985@1|root,COG0117@2|Bacteria,COG1985@2|Bacteria,1MUWT@1224|Proteobacteria,2TR70@28211|Alphaproteobacteria,2K10R@204457|Sphingomonadales 204457|Sphingomonadales H Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate ribD - 1.1.1.193,3.5.4.26 ko:K11752 ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024 M00125 R03458,R03459 RC00204,RC00933 ko00000,ko00001,ko00002,ko01000 - - - RibD_C,dCMP_cyt_deam_1 k59_932177_1 1229909.NSED_00415 1.71e-123 353.0 COG4276@1|root,arCOG04604@2157|Archaea,41SI9@651137|Thaumarchaeota 651137|Thaumarchaeota S Activator of Hsp90 ATPase homolog 1-like protein - - - - - - - - - - - - Polyketide_cyc2 k59_596423_1 436308.Nmar_1455 4.94e-25 103.0 COG0015@1|root,arCOG01747@2157|Archaea,41SD1@651137|Thaumarchaeota 651137|Thaumarchaeota F adenylosuccinate lyase - - 4.3.2.2 ko:K01756 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048,M00049 R01083,R04559 RC00379,RC00444,RC00445 ko00000,ko00001,ko00002,ko01000 - - - ADSL_C,Lyase_1 k59_596423_2 56110.Oscil6304_3012 2.05e-39 140.0 COG0546@1|root,COG0546@2|Bacteria,1G52P@1117|Cyanobacteria,1HB0I@1150|Oscillatoriales 1117|Cyanobacteria S PFAM Haloacid dehalogenase-like hydrolase cbbZp - 3.1.3.18 ko:K01091 ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130 - R01334 RC00017 ko00000,ko00001,ko01000 - - - HAD_2 k59_32154_1 1229909.NSED_08165 1.18e-104 323.0 COG1048@1|root,arCOG01697@2157|Archaea,41SE6@651137|Thaumarchaeota 651137|Thaumarchaeota C aconitate hydratase - - 4.2.1.3 ko:K01681 ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00173,M00740 R01324,R01325,R01900 RC00497,RC00498,RC00618 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase,Aconitase_C k59_1388285_1 1415778.JQMM01000001_gene2024 4.67e-18 90.1 COG1835@1|root,COG1835@2|Bacteria,1RFAU@1224|Proteobacteria,1RZVV@1236|Gammaproteobacteria,1JA75@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria I Acyltransferase family - - - - - - - - - - - - Acyl_transf_3 k59_480012_1 316407.85675587 6.75e-113 333.0 COG0644@1|root,COG0644@2|Bacteria,1MVU6@1224|Proteobacteria,1RNY5@1236|Gammaproteobacteria,3XMS4@561|Escherichia 1236|Gammaproteobacteria C electron transfer flavoprotein-quinone oxidoreductase YgcN ygcN GO:0006575,GO:0006577,GO:0006807,GO:0008150,GO:0008152,GO:0009437,GO:0009987,GO:0034641,GO:0044237,GO:0071704,GO:0097164,GO:1901564 - ko:K00313 - - - - ko00000,ko01000 - - - DAO,FAD_binding_2,FAD_binding_3 k59_535302_1 1123368.AUIS01000015_gene2619 1.36e-14 75.9 COG3182@1|root,COG3182@2|Bacteria,1QVX4@1224|Proteobacteria,1T2MJ@1236|Gammaproteobacteria 1236|Gammaproteobacteria S PepSY-associated TM region - - - - - - - - - - - - PepSY_TM k59_535302_2 1565129.JSFF01000002_gene3447 4.96e-06 47.8 COG4659@1|root,COG4659@2|Bacteria,1MZVX@1224|Proteobacteria,1S9KJ@1236|Gammaproteobacteria,2QBRU@267890|Shewanellaceae 1236|Gammaproteobacteria C FMN-binding domain protein - - - - - - - - - - - - FMN_bind k59_199360_1 247639.MGP2080_00090 9.43e-08 50.1 COG0268@1|root,COG0268@2|Bacteria,1MZ94@1224|Proteobacteria,1S9AI@1236|Gammaproteobacteria 1236|Gammaproteobacteria J Binds directly to 16S ribosomal RNA rpsT GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0004857,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008073,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030234,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0042979,GO:0043043,GO:0043086,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044092,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0050790,GO:0065003,GO:0065007,GO:0065009,GO:0070181,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:0098772,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02968 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S20p k59_199360_2 637905.SVI_4299 1.09e-10 64.7 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,1RMH0@1236|Gammaproteobacteria,2QAI3@267890|Shewanellaceae 1236|Gammaproteobacteria NT PFAM histidine kinase, HAMP region domain protein - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - HAMP,MCPsignal,dCache_3 k59_762325_1 640081.Dsui_2889 4.33e-58 189.0 COG0760@1|root,COG0760@2|Bacteria,1MZDK@1224|Proteobacteria,2VJZP@28216|Betaproteobacteria,2KVE7@206389|Rhodocyclales 206389|Rhodocyclales M peptidylprolyl isomerase - - 5.2.1.8 ko:K03769 - - - - ko00000,ko01000,ko03110 - - - Rotamase_3 k59_649834_1 1229909.NSED_09735 4.11e-23 91.7 arCOG08804@1|root,arCOG08804@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_199376_1 215803.DB30_6876 1.13e-22 102.0 COG1858@1|root,COG2706@1|root,COG3391@1|root,COG1858@2|Bacteria,COG2706@2|Bacteria,COG3391@2|Bacteria,1R66T@1224|Proteobacteria,439FZ@68525|delta/epsilon subdivisions,2X4RS@28221|Deltaproteobacteria,2YZGC@29|Myxococcales 28221|Deltaproteobacteria G 6-phosphogluconolactonase activity - - - - - - - - - - - - Lactonase k59_1049308_1 1232410.KI421425_gene1549 7.81e-85 280.0 COG4105@1|root,COG4105@2|Bacteria,1QVQ9@1224|Proteobacteria,43CT2@68525|delta/epsilon subdivisions,2X80K@28221|Deltaproteobacteria,43TUA@69541|Desulfuromonadales 28221|Deltaproteobacteria S Tetratricopeptide repeat - - - - - - - - - - - - TPR_16,TPR_6 k59_1160129_1 1249997.JHZW01000003_gene2150 7.72e-11 67.8 COG2133@1|root,COG3291@1|root,COG2133@2|Bacteria,COG3291@2|Bacteria,4PI47@976|Bacteroidetes,1IM97@117743|Flavobacteriia,2PI57@252356|Maribacter 976|Bacteroidetes G Glucose / Sorbosone dehydrogenase - - - - - - - - - - - - GSDH,PKD k59_1558448_2 1396858.Q666_11890 2.17e-42 144.0 COG3245@1|root,COG3245@2|Bacteria,1MZBZ@1224|Proteobacteria,1S9Z9@1236|Gammaproteobacteria,467R4@72275|Alteromonadaceae 1236|Gammaproteobacteria C COG3245 Cytochrome c5 cyc - 1.9.3.1 ko:K02277 ko00190,ko01100,map00190,map01100 M00155 - - ko00000,ko00001,ko00002,ko01000 3.D.4.4 - - Cytochrome_CBB3 k59_424465_2 1207055.C100_18225 1.19e-06 50.1 COG1028@1|root,COG1028@2|Bacteria,1RGP0@1224|Proteobacteria,2U8CZ@28211|Alphaproteobacteria 28211|Alphaproteobacteria IQ KR domain - - - - - - - - - - - - adh_short,adh_short_C2 k59_819738_1 518766.Rmar_0728 8e-12 64.3 COG2885@1|root,COG2885@2|Bacteria,4NEGF@976|Bacteroidetes,1FJ6B@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes M Glycine zipper - - - - - - - - - - - - Gly-zipper_Omp,OmpA,PD40 k59_819738_2 290398.Csal_2522 4.94e-11 64.3 COG2832@1|root,COG2832@2|Bacteria,1N7BI@1224|Proteobacteria,1SCJZ@1236|Gammaproteobacteria,1XKZT@135619|Oceanospirillales 135619|Oceanospirillales S membrane - - - ko:K09790 - - - - ko00000 - - - DUF454 k59_762339_1 1122214.AQWH01000030_gene4911 1.97e-72 234.0 COG0174@1|root,COG0174@2|Bacteria,1MU6V@1224|Proteobacteria,2TRCP@28211|Alphaproteobacteria,2PJDZ@255475|Aurantimonadaceae 28211|Alphaproteobacteria E Glutamine synthetase, catalytic domain - - 6.3.1.2 ko:K01915 ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 - R00253 RC00010,RC02798 ko00000,ko00001,ko01000,ko04147 - - - Gln-synt_C k59_762339_2 1244869.H261_08538 8.57e-34 127.0 COG2071@1|root,COG2071@2|Bacteria,1MV8E@1224|Proteobacteria,2TSU3@28211|Alphaproteobacteria,2JPIW@204441|Rhodospirillales 204441|Rhodospirillales S Peptidase C26 - - - ko:K07010 - - - - ko00000,ko01002 - - - Peptidase_C26 k59_1613114_1 161528.ED21_23671 1.67e-44 157.0 COG3504@1|root,COG3504@2|Bacteria,1MVEF@1224|Proteobacteria,2TR8Y@28211|Alphaproteobacteria,2K1EQ@204457|Sphingomonadales 204457|Sphingomonadales U transfer protein TrbG trbG - - ko:K20532 ko02024,map02024 - - - ko00000,ko00001,ko02044 3.A.7.4 - - CagX k59_1558463_1 436308.Nmar_0240 1.64e-93 281.0 COG0470@1|root,arCOG00469@2157|Archaea,41SFJ@651137|Thaumarchaeota 651137|Thaumarchaeota L Replication factor C - - - ko:K04801 ko03030,map03030 - - - ko00000,ko00001,ko03032 - - - DNA_pol3_delta2,Rep_fac_C,RuvB_N k59_148758_1 323850.Shew_3271 5.51e-57 192.0 COG0153@1|root,COG0153@2|Bacteria,1MVQD@1224|Proteobacteria,1RQ0C@1236|Gammaproteobacteria,2Q9HT@267890|Shewanellaceae 1236|Gammaproteobacteria H Belongs to the GHMP kinase family. GalK subfamily galK - 2.7.1.6 ko:K00849 ko00052,ko00520,ko01100,map00052,map00520,map01100 M00554,M00632 R01092 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000,ko04147 - - - GHMP_kinases_C,GHMP_kinases_N,GalKase_gal_bdg k59_1395155_1 926569.ANT_30510 2.51e-32 123.0 COG3118@1|root,COG3118@2|Bacteria,2G90Y@200795|Chloroflexi 200795|Chloroflexi O PFAM Thioredoxin domain - - - ko:K05838 - - - - ko00000,ko03110 - - - TPR_19,TPR_20,Thioredoxin k59_655432_1 1121939.L861_17185 6.14e-57 194.0 COG1502@1|root,COG1502@2|Bacteria,1MXA6@1224|Proteobacteria,1RZZ7@1236|Gammaproteobacteria,1XMX6@135619|Oceanospirillales 135619|Oceanospirillales I PLD-like domain - - - - - - - - - - - - PLDc_2 k59_485279_1 383372.Rcas_1888 1.5e-38 141.0 COG1960@1|root,COG1960@2|Bacteria,2G6E5@200795|Chloroflexi,3763W@32061|Chloroflexia 32061|Chloroflexia C PFAM acyl-CoA dehydrogenase domain protein - - 1.3.8.7 ko:K00249 ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320 M00013,M00036,M00087 R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754 RC00052,RC00068,RC00076,RC00095,RC00148,RC00246 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_38913_1 1267533.KB906739_gene2602 2.18e-05 53.1 COG0624@1|root,COG0624@2|Bacteria,3Y6ST@57723|Acidobacteria,2JM9Q@204432|Acidobacteriia 204432|Acidobacteriia E Peptidase dimerisation domain - - 3.4.17.11 ko:K01295 - - - - ko00000,ko01000,ko01002 - - - M20_dimer,Peptidase_M20 k59_767598_1 225937.HP15_936 1.49e-43 152.0 COG0583@1|root,COG0583@2|Bacteria,1MW16@1224|Proteobacteria,1RPNX@1236|Gammaproteobacteria,4670G@72275|Alteromonadaceae 1236|Gammaproteobacteria K COG0583 Transcriptional regulator - - - - - - - - - - - - HTH_1,LysR_substrate k59_1673919_1 436308.Nmar_1004 2.67e-24 102.0 COG0405@1|root,arCOG04053@2157|Archaea 2157|Archaea E gamma-glutamyltransferase ggt - 2.3.2.2,3.4.19.13 ko:K00681 ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100 - R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935 RC00064,RC00090,RC00096 ko00000,ko00001,ko01000,ko01002 - - - G_glu_transpept k59_1673919_2 436308.Nmar_1003 1.38e-136 392.0 COG3741@1|root,arCOG08266@2157|Archaea 2157|Archaea E N-formylglutamate amidohydrolase - - 3.5.3.8 ko:K01479 ko00340,ko01100,map00340,map01100 M00045 R02285 RC00221,RC00681 ko00000,ko00001,ko00002,ko01000 - - - FGase k59_1673920_1 634177.GLX_24920 1.13e-10 64.3 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2TQW2@28211|Alphaproteobacteria,2JQX5@204441|Rhodospirillales 204441|Rhodospirillales T COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains ntrX - - ko:K13599 ko02020,map02020 M00498 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_1673920_2 391937.NA2_00630 1.05e-46 156.0 COG0262@1|root,COG0262@2|Bacteria,1RH0P@1224|Proteobacteria,2U9GC@28211|Alphaproteobacteria,43JSB@69277|Phyllobacteriaceae 28211|Alphaproteobacteria H Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis folA - 1.5.1.3 ko:K00287 ko00670,ko00790,ko01100,ko01523,map00670,map00790,map01100,map01523 M00126,M00840 R00936,R00937,R00939,R00940,R02235,R02236,R11765 RC00109,RC00110,RC00158 ko00000,ko00001,ko00002,ko01000 - - - DHFR_1 k59_1619603_1 748658.KB907312_gene1887 2.22e-22 101.0 COG2199@1|root,COG2208@1|root,COG2208@2|Bacteria,COG3706@2|Bacteria,1N4K5@1224|Proteobacteria,1RNYP@1236|Gammaproteobacteria,1WXFR@135613|Chromatiales 135613|Chromatiales T response regulator receiver - - - ko:K20977 ko02020,ko02025,map02020,map02025 M00820 - - ko00000,ko00001,ko00002,ko02022 - - - HATPase_c_2,Response_reg,SpoIIE k59_1566686_1 1121012.AUKX01000098_gene2633 5.55e-90 279.0 COG5421@1|root,COG5421@2|Bacteria,4PAGJ@976|Bacteroidetes,1IAIH@117743|Flavobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - DDE_Tnp_1 k59_604794_1 506534.Rhein_3939 1.82e-19 84.7 COG1253@1|root,COG1253@2|Bacteria,1R0P6@1224|Proteobacteria,1T4MB@1236|Gammaproteobacteria,1X2SB@135613|Chromatiales 135613|Chromatiales S CBS domain - - - - - - - - - - - - CBS k59_1732105_1 709797.CSIRO_0007 9.61e-91 280.0 COG0526@1|root,COG0526@2|Bacteria,1RC8N@1224|Proteobacteria,2U7IW@28211|Alphaproteobacteria,3K48V@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria CO COG0526, thiol-disulfide isomerase and thioredoxins - - - - - - - - - - - - AhpC-TSA k59_604795_1 1254432.SCE1572_15655 6.89e-148 457.0 COG1858@1|root,COG3391@1|root,COG1858@2|Bacteria,COG3391@2|Bacteria,1R66T@1224|Proteobacteria,439FZ@68525|delta/epsilon subdivisions,2X4RS@28221|Deltaproteobacteria,2YZGC@29|Myxococcales 28221|Deltaproteobacteria G 6-phosphogluconolactonase activity - - - - - - - - - - - - - k59_1784057_3 1254432.SCE1572_42335 2.84e-26 110.0 COG1530@1|root,COG1530@2|Bacteria,1MV65@1224|Proteobacteria,42M5E@68525|delta/epsilon subdivisions,2WIV6@28221|Deltaproteobacteria,2YTXT@29|Myxococcales 28221|Deltaproteobacteria J Ribonuclease E/G family cafA - - ko:K08301 - - - - ko00000,ko01000,ko03009,ko03019 - - - RNase_E_G,S1 k59_1277314_1 583355.Caka_1487 5.09e-45 164.0 COG1629@1|root,COG4771@2|Bacteria 2|Bacteria P TonB-dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - CarbopepD_reg_2,Plug,TonB_dep_Rec k59_1334131_1 436308.Nmar_1727 2.74e-125 374.0 COG1782@1|root,arCOG00543@2157|Archaea,41T05@651137|Thaumarchaeota 651137|Thaumarchaeota S RNA-metabolising metallo-beta-lactamase - - - ko:K07041 - - - - ko00000 - - - Beta-Casp,KH_7,Lactamase_B_6,RMMBL k59_39970_1 1038859.AXAU01000026_gene2331 1.97e-112 331.0 COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,2TRS8@28211|Alphaproteobacteria,3JS1M@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria EP Binding-protein-dependent transport system inner membrane component nikB - - ko:K02033,ko:K15585 ko02010,ko02024,map02010,map02024 M00239,M00440 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1 k59_1277321_2 1283284.AZUK01000001_gene1526 0.000403 47.8 COG0706@1|root,COG0706@2|Bacteria,1MV5M@1224|Proteobacteria,1RMH1@1236|Gammaproteobacteria,1Y3NC@135624|Aeromonadales 135624|Aeromonadales U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins yidC - - ko:K03217 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044,ko03029 2.A.9 - - 60KD_IMP,YidC_periplas k59_541600_1 385682.AFSL01000008_gene2633 1.66e-51 182.0 COG0477@1|root,COG2814@2|Bacteria,4NG5F@976|Bacteroidetes,2FPA7@200643|Bacteroidia,3XISH@558415|Marinilabiliaceae 976|Bacteroidetes EGP BT1 family ampG - - ko:K08218 ko01501,map01501 M00628 - - ko00000,ko00001,ko00002,ko02000 2.A.1.25 - - BT1,MFS_1 k59_95651_1 1380355.JNIJ01000022_gene3553 1.03e-24 107.0 COG0633@1|root,COG2114@1|root,COG0633@2|Bacteria,COG2114@2|Bacteria,1N5XC@1224|Proteobacteria,2TRGX@28211|Alphaproteobacteria,3JQU2@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria CT Adenylyl- / guanylyl cyclase, catalytic domain cyaA - 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 - - - Fer2,Guanylate_cyc k59_1396176_1 1229909.NSED_00530 9.15e-33 123.0 COG4742@1|root,arCOG04362@2157|Archaea,41SGE@651137|Thaumarchaeota 651137|Thaumarchaeota K Transcriptional regulator - - - - - - - - - - - - HTH_20,HTH_5 k59_1396176_2 1459636.NTE_03296 3.35e-35 135.0 COG0467@1|root,arCOG01171@2157|Archaea 2157|Archaea T Circadian clock protein KaiC - - - ko:K06945 - - - - ko00000 - - - ATPase,Arf,Robl_LC7,zf-FCS k59_768913_1 391165.GbCGDNIH1_0105 1.98e-66 212.0 COG1091@1|root,COG1091@2|Bacteria,1MUXM@1224|Proteobacteria,2TSP6@28211|Alphaproteobacteria,2JPW5@204441|Rhodospirillales 204441|Rhodospirillales M Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose rfbD - 1.1.1.133 ko:K00067 ko00521,ko00523,ko01130,map00521,map00523,map01130 M00793 R02777 RC00182 ko00000,ko00001,ko00002,ko01000 - - - RmlD_sub_bind k59_768913_2 1122137.AQXF01000005_gene1387 6.97e-160 453.0 COG1209@1|root,COG1209@2|Bacteria,1MU0X@1224|Proteobacteria,2TQPI@28211|Alphaproteobacteria 28211|Alphaproteobacteria M Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis rfbA - 2.7.7.24 ko:K00973 ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130 M00793 R02328 RC00002 ko00000,ko00001,ko00002,ko01000 - - - NTP_transferase k59_430777_1 746697.Aeqsu_0738 6.89e-107 320.0 COG0270@1|root,COG0270@2|Bacteria,4NG9A@976|Bacteroidetes,1HZAK@117743|Flavobacteriia 976|Bacteroidetes H cytosine-specific methyltransferase hpaIIM - 2.1.1.37 ko:K00558 ko00270,ko01100,ko05206,map00270,map01100,map05206 M00035 R04858 RC00003,RC00332 ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036 - - - DNA_methylase k59_1396179_1 1122137.AQXF01000005_gene1249 1.18e-278 787.0 COG3383@1|root,COG3383@2|Bacteria,1QTZB@1224|Proteobacteria,2TVZI@28211|Alphaproteobacteria 28211|Alphaproteobacteria C Formate dehydrogenase, alpha subunit - - 1.17.1.9 ko:K00123 ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200 - R00519 RC02796 ko00000,ko00001,ko01000 - - - Fer2_4,Fer4,Fer4_6,Fer4_7,Fer4_9,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3 k59_1673964_1 247633.GP2143_06903 1.25e-101 306.0 COG1878@1|root,COG1878@2|Bacteria,1MVWU@1224|Proteobacteria,1RQSC@1236|Gammaproteobacteria,1JB4N@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Putative cyclase - - - - - - - - - - - - Cyclase k59_1619632_1 1208583.COMX_03830 1e-14 73.6 COG0169@1|root,COG0169@2|Bacteria,1MVH4@1224|Proteobacteria,2TS99@28211|Alphaproteobacteria,2JPBD@204441|Rhodospirillales 204441|Rhodospirillales E Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) aroE - 1.1.1.25 ko:K00014 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02413 RC00206 ko00000,ko00001,ko00002,ko01000 - - - Shikimate_DH,Shikimate_dh_N k59_1619632_2 1122137.AQXF01000001_gene3251 6.83e-95 281.0 COG0237@1|root,COG0237@2|Bacteria,1RCXT@1224|Proteobacteria,2U765@28211|Alphaproteobacteria 28211|Alphaproteobacteria H Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A coaE GO:0003674,GO:0003824,GO:0004140,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.1.24 ko:K00859 ko00770,ko01100,map00770,map01100 M00120 R00130 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - CoaE k59_1619632_3 1122137.AQXF01000001_gene3252 1.26e-05 45.8 COG0847@1|root,COG0847@2|Bacteria,1MV8Z@1224|Proteobacteria,2TTFF@28211|Alphaproteobacteria 28211|Alphaproteobacteria L DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease dnaQ GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008408,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0016787,GO:0016788,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0042575,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0044776,GO:0045004,GO:0045005,GO:0046483,GO:0050896,GO:0051716,GO:0061695,GO:0071704,GO:0090304,GO:0090305,GO:1901360,GO:1901576,GO:1902494,GO:1990234 2.7.7.7 ko:K02342 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - RNase_T k59_1334148_1 555500.I215_07791 1.63e-43 156.0 COG0246@1|root,COG0246@2|Bacteria,4NEMT@976|Bacteroidetes,1I085@117743|Flavobacteriia 976|Bacteroidetes G PFAM Mannitol dehydrogenase C-terminal domain uxaB GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006063,GO:0006082,GO:0008150,GO:0008152,GO:0009026,GO:0009056,GO:0009987,GO:0016052,GO:0016054,GO:0016491,GO:0016614,GO:0016616,GO:0019586,GO:0019698,GO:0019752,GO:0032787,GO:0036094,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046395,GO:0046396,GO:0046397,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0071704,GO:0072329,GO:0097159,GO:1901265,GO:1901363,GO:1901575 1.1.1.17,1.1.1.58 ko:K00009,ko:K00041 ko00040,ko00051,ko01100,map00040,map00051,map01100 M00631 R02555,R02703 RC00085 ko00000,ko00001,ko00002,ko01000 - - - Mannitol_dh,Mannitol_dh_C k59_1334148_2 991.IW20_24160 2.13e-07 52.0 COG2721@1|root,COG2721@2|Bacteria,4NFVQ@976|Bacteroidetes,1HXWR@117743|Flavobacteriia,2NSCU@237|Flavobacterium 976|Bacteroidetes G Altronate hydrolase uxaA - 4.2.1.7 ko:K01685 ko00040,ko01100,map00040,map01100 M00631 R01540 RC00543 ko00000,ko00001,ko00002,ko01000 - - - GD_AH_C,SAF k59_827774_1 570952.ATVH01000013_gene2944 4.13e-05 45.4 COG0237@1|root,COG0237@2|Bacteria,1RCXT@1224|Proteobacteria,2U765@28211|Alphaproteobacteria,2JSB5@204441|Rhodospirillales 204441|Rhodospirillales H Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A coaE - 2.7.1.24 ko:K00859 ko00770,ko01100,map00770,map01100 M00120 R00130 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - CoaE k59_827774_2 1123501.KB902314_gene3195 3.07e-83 252.0 COG0847@1|root,COG0847@2|Bacteria,1MV8Z@1224|Proteobacteria,2TTFF@28211|Alphaproteobacteria 28211|Alphaproteobacteria L DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease dnaQ - 2.7.7.7 ko:K02342 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - RNase_T k59_1447699_1 316407.85675947 1.63e-120 350.0 COG0701@1|root,COG0701@2|Bacteria,1MUN8@1224|Proteobacteria,1RR9N@1236|Gammaproteobacteria,3XMSV@561|Escherichia 1236|Gammaproteobacteria S Predicted permease yraQ GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K07089 - - - - ko00000 - - - ArsP_1 k59_1056233_1 29908.U7PPC4 2.11e-15 75.5 COG1085@1|root,KOG2958@2759|Eukaryota,38ED2@33154|Opisthokonta,3NU1J@4751|Fungi,3QK2X@4890|Ascomycota,211AR@147550|Sordariomycetes,3UQZ2@5151|Ophiostomatales 4751|Fungi H Galactose-1-phosphate uridyl transferase, C-terminal domain GAL7 GO:0003674,GO:0003824,GO:0004335,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006012,GO:0006139,GO:0006464,GO:0006486,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008108,GO:0008150,GO:0008152,GO:0008198,GO:0008270,GO:0009056,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009226,GO:0009987,GO:0016052,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016779,GO:0018130,GO:0019200,GO:0019318,GO:0019320,GO:0019388,GO:0019438,GO:0019538,GO:0033499,GO:0034641,GO:0034645,GO:0034654,GO:0036211,GO:0042125,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044267,GO:0044271,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046483,GO:0046835,GO:0046872,GO:0046914,GO:0052573,GO:0052574,GO:0055086,GO:0070085,GO:0070569,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576 2.7.7.12 ko:K00965 ko00052,ko00520,ko01100,ko04917,map00052,map00520,map01100,map04917 M00362,M00554,M00632 R00955 RC00002 ko00000,ko00001,ko00002,ko01000 - - - GalP_UDP_tr_C,GalP_UDP_transf k59_1056233_2 1250006.JHZZ01000001_gene536 2.65e-38 139.0 COG0153@1|root,COG0153@2|Bacteria,4NE0C@976|Bacteroidetes,1HWZC@117743|Flavobacteriia,3VW7H@52959|Polaribacter 976|Bacteroidetes G Galactokinase galactose-binding signature galK - 2.7.1.6 ko:K00849 ko00052,ko00520,ko01100,map00052,map00520,map01100 M00554,M00632 R01092 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000,ko04147 - - - GHMP_kinases_C,GHMP_kinases_N,GalKase_gal_bdg k59_1108749_1 1177928.TH2_11574 2.49e-15 74.7 COG0590@1|root,COG0590@2|Bacteria,1R7ZH@1224|Proteobacteria,2VGAS@28211|Alphaproteobacteria 28211|Alphaproteobacteria FJ deaminase - - - - - - - - - - - - MafB19-deam,dCMP_cyt_deam_1 k59_1108749_2 1075090.GOAMR_33_00710 4.6e-111 331.0 COG1960@1|root,COG1960@2|Bacteria,2GIX8@201174|Actinobacteria,4GC5F@85026|Gordoniaceae 201174|Actinobacteria I Acyl-CoA dehydrogenase, C-terminal domain - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_888064_1 511145.b2405 4.76e-156 441.0 COG0583@1|root,COG0583@2|Bacteria,1MV0Z@1224|Proteobacteria,1SYPN@1236|Gammaproteobacteria,3XN83@561|Escherichia 1236|Gammaproteobacteria K Positive regulator required for the expression of xapA and xapB. Binds to the inducer xanthosine xapR GO:0003674,GO:0003700,GO:0006355,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0140110,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141 - ko:K21757 - - - - ko00000,ko03000 - - - HTH_1,LysR_substrate k59_1224163_2 713587.THITH_14345 8.23e-82 244.0 COG0080@1|root,COG0080@2|Bacteria,1RA2M@1224|Proteobacteria,1S22R@1236|Gammaproteobacteria,1WXZD@135613|Chromatiales 135613|Chromatiales J Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors rplK - - ko:K02867 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L11,Ribosomal_L11_N k59_150051_1 316407.85677025 3.23e-46 149.0 COG2963@1|root,COG2963@2|Bacteria,1N10J@1224|Proteobacteria,1S994@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Transposase IS3 IS911 family protein - - - ko:K07483 - - - - ko00000 - - - HTH_Tnp_1 k59_150051_2 469008.B21_04108 3.41e-38 128.0 COG2271@1|root,COG2271@2|Bacteria,1MVPS@1224|Proteobacteria,1S0GA@1236|Gammaproteobacteria 1236|Gammaproteobacteria G Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 k59_1224166_1 1122137.AQXF01000005_gene1209 3.33e-107 325.0 COG0659@1|root,COG0659@2|Bacteria,1MXA7@1224|Proteobacteria,2TV6Y@28211|Alphaproteobacteria 28211|Alphaproteobacteria P secondary active sulfate transmembrane transporter activity MA20_17540 - - ko:K06901 - - - - ko00000,ko02000 2.A.1.40 - - - k59_1334164_1 204669.Acid345_2966 2.03e-83 261.0 COG2079@1|root,COG2079@2|Bacteria,3Y5N1@57723|Acidobacteria,2JK64@204432|Acidobacteriia 204432|Acidobacteriia S MmgE/PrpD family - - 4.2.1.79 ko:K01720 ko00640,map00640 - R04424 RC01152 ko00000,ko00001,ko01000 - - - MmgE_PrpD k59_150053_1 1096930.L284_01725 2.45e-72 227.0 COG0385@1|root,COG0385@2|Bacteria,1MUMM@1224|Proteobacteria,2TU7J@28211|Alphaproteobacteria,2K0HH@204457|Sphingomonadales 204457|Sphingomonadales S Bile acid sodium symporter - - - ko:K14347 - - - - ko00000,ko02000,ko04147 2.A.93.1 - - SBF_like k59_1277377_1 330214.NIDE3256 1.11e-224 623.0 COG1140@1|root,COG1140@2|Bacteria,3J1FU@40117|Nitrospirae 2|Bacteria C Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology ddhB GO:0005575,GO:0005623,GO:0042597,GO:0044464 1.7.5.1 ko:K00371,ko:K16965,ko:K17048,ko:K17051 ko00642,ko00910,ko00920,ko01100,ko01120,ko01220,ko02020,map00642,map00910,map00920,map01100,map01120,map01220,map02020 M00529,M00530,M00804 R00798,R01106,R05745,R09497,R09500 RC00275,RC02555,RC02812 ko00000,ko00001,ko00002,ko01000,ko02000 5.A.3.1,5.A.3.8,5.A.3.9 - - Fer4_11 k59_323302_1 316407.85676126 1.27e-46 158.0 COG1609@1|root,COG1609@2|Bacteria,1MVUR@1224|Proteobacteria,1RN8T@1236|Gammaproteobacteria,3XNJP@561|Escherichia 1236|Gammaproteobacteria K This protein negatively controls the transcription initiation of genes such as deoCABD, udp, and cdd encoding catabolizing enzymes and nupC, nupG, and tsx encoding transporting and pore-forming proteins. Binds cytidine and adenosine as effectors cytR GO:0000976,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0043565,GO:0044212,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2001141 - ko:K05499 - - - - ko00000,ko03000 - - - LacI,Peripla_BP_3 k59_323302_2 199310.c4888 3.32e-40 146.0 COG1198@1|root,COG1198@2|Bacteria,1MUUZ@1224|Proteobacteria,1RPZ7@1236|Gammaproteobacteria,3XNVC@561|Escherichia 1236|Gammaproteobacteria L Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA priA GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006268,GO:0006270,GO:0006276,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009628,GO:0009987,GO:0010212,GO:0010332,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0033554,GO:0034641,GO:0034645,GO:0042221,GO:0042623,GO:0043138,GO:0043140,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0046483,GO:0046677,GO:0050896,GO:0051276,GO:0051716,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360,GO:1901576 - ko:K04066 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,Helicase_C,ResIII k59_150056_1 42256.RradSPS_1297 4.93e-31 115.0 COG0590@1|root,COG0590@2|Bacteria,2I9KR@201174|Actinobacteria 201174|Actinobacteria FJ CMP dCMP deaminase, zinc-binding - - - - - - - - - - - - dCMP_cyt_deam_1 k59_150056_2 290317.Cpha266_1912 3.71e-33 129.0 COG0598@1|root,COG0598@2|Bacteria,1FEBZ@1090|Chlorobi 1090|Chlorobi P Mediates influx of magnesium ions corA - - ko:K03284,ko:K16074 - - - - ko00000,ko02000 1.A.35.1,1.A.35.3,1.A.35.4 - - CorA k59_95718_1 1229909.NSED_01215 7.34e-183 520.0 COG0165@1|root,arCOG01748@2157|Archaea,41S6A@651137|Thaumarchaeota 651137|Thaumarchaeota E argininosuccinate lyase argH - 4.3.2.1 ko:K01755 ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230 M00029,M00844,M00845 R01086 RC00445,RC00447 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ASL_C2,Lyase_1 k59_1447723_1 573061.Clocel_2482 6.53e-51 184.0 COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,36EG3@31979|Clostridiaceae 186801|Clostridia Q TIGRFAM amino acid adenylation domain - - - - - - - - - - - - AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase k59_264890_1 1122137.AQXF01000001_gene3376 7.93e-156 454.0 COG0441@1|root,COG0441@2|Bacteria,1MUP2@1224|Proteobacteria,2TQWI@28211|Alphaproteobacteria 28211|Alphaproteobacteria J Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) thrS - 6.1.1.3 ko:K01868 ko00970,map00970 M00359,M00360 R03663 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,TGS,tRNA-synt_2b,tRNA_SAD k59_1509321_1 1283299.AUKG01000001_gene1980 1.74e-90 280.0 COG0031@1|root,COG0031@2|Bacteria,2GIXE@201174|Actinobacteria,4CRTD@84995|Rubrobacteria 84995|Rubrobacteria E Pyridoxal-phosphate dependent enzyme - - 4.2.1.22 ko:K01697 ko00260,ko00270,ko01100,ko01130,ko01230,map00260,map00270,map01100,map01130,map01230 M00035,M00338 R00891,R01290,R04942 RC00056,RC00069,RC00256,RC00489,RC01246 ko00000,ko00001,ko00002,ko01000 - - - CBS,PALP k59_604849_1 1260251.SPISAL_08165 4.51e-15 70.1 2C0ET@1|root,33A9M@2|Bacteria,1NGE5@1224|Proteobacteria,1SX58@1236|Gammaproteobacteria,1WZBH@135613|Chromatiales 135613|Chromatiales S TIGRFAM TIGR02449 family protein - - - ko:K09892 - - - - ko00000,ko03036 - - - - k59_604849_2 314278.NB231_13186 5.59e-22 89.7 COG3027@1|root,COG3027@2|Bacteria,1N6YN@1224|Proteobacteria,1SCBI@1236|Gammaproteobacteria,1WZ69@135613|Chromatiales 135613|Chromatiales D Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division - - - ko:K09888 - - - - ko00000,ko03036 - - - ZapA k59_717920_1 158500.BV97_01429 8.27e-27 106.0 COG1960@1|root,COG1960@2|Bacteria,1MVJC@1224|Proteobacteria,2TTRD@28211|Alphaproteobacteria,2K02R@204457|Sphingomonadales 204457|Sphingomonadales I PFAM Acyl-CoA dehydrogenase, C-terminal domain, Acyl-CoA dehydrogenase, middle domain, Acyl-CoA dehydrogenase, N-terminal domain - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_717920_2 1123270.ATUR01000006_gene160 4.78e-53 177.0 COG1960@1|root,COG1960@2|Bacteria,1NUZC@1224|Proteobacteria,2URRT@28211|Alphaproteobacteria,2K4NX@204457|Sphingomonadales 204457|Sphingomonadales I Acyl-CoA dehydrogenase, C-terminal domain - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_N k59_604865_1 702113.PP1Y_AT18579 2.23e-118 342.0 COG1192@1|root,COG1192@2|Bacteria,1MWH3@1224|Proteobacteria,2U100@28211|Alphaproteobacteria,2K0JR@204457|Sphingomonadales 204457|Sphingomonadales D involved in chromosome partitioning - - - ko:K03496 - - - - ko00000,ko03036,ko04812 - - - AAA_31 k59_939148_1 760154.Sulba_1903 9.84e-33 126.0 COG0438@1|root,COG0438@2|Bacteria,1MU9C@1224|Proteobacteria,42T55@68525|delta/epsilon subdivisions,2YQJT@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Glycosyl transferase 4-like - - - ko:K00754 - - - - ko00000,ko01000 - GT4 - Glyco_trans_4_2,Glyco_transf_4,Glycos_transf_1 k59_656646_1 469378.Ccur_09540 2.9e-36 140.0 COG0769@1|root,COG0769@2|Bacteria,2GIS2@201174|Actinobacteria,4CUCK@84998|Coriobacteriia 84998|Coriobacteriia M Belongs to the MurCDEF family. MurE subfamily murE - 6.3.2.13 ko:K01928 ko00300,ko00550,map00300,map00550 - R02788 RC00064,RC00090 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_95751_1 1122137.AQXF01000002_gene244 1.94e-160 456.0 COG0343@1|root,COG0343@2|Bacteria,1MUCA@1224|Proteobacteria,2TR87@28211|Alphaproteobacteria 28211|Alphaproteobacteria J Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) tgt - 2.4.2.29 ko:K00773 - - R03789,R10209 RC00063 ko00000,ko01000,ko03016 - - - TGT k59_1619723_1 656519.Halsa_1260 1.04e-25 109.0 COG0038@1|root,COG5002@1|root,COG0038@2|Bacteria,COG5002@2|Bacteria,1TPX0@1239|Firmicutes,247R4@186801|Clostridia 186801|Clostridia P Chloride transporter, ClC family - - - ko:K03281 - - - - ko00000 2.A.49 - - CBS,Voltage_CLC k59_1784130_1 143224.JQMD01000002_gene1657 5.12e-30 122.0 COG1629@1|root,COG1629@2|Bacteria,4NDXS@976|Bacteroidetes,1HWYV@117743|Flavobacteriia 976|Bacteroidetes P TonB-dependent receptor plug - - - - - - - - - - - - CarbopepD_reg_2,Plug,TonB_dep_Rec k59_1784130_2 555500.I215_07806 4.45e-55 182.0 COG1609@1|root,COG1609@2|Bacteria,4NDW6@976|Bacteroidetes,1HY65@117743|Flavobacteriia 976|Bacteroidetes K lacI family - - - ko:K02529 - - - - ko00000,ko03000 - - - LacI,Peripla_BP_1,Peripla_BP_3 k59_1396240_1 1122137.AQXF01000004_gene1846 1.92e-66 211.0 COG2070@1|root,COG2070@2|Bacteria,1MWPC@1224|Proteobacteria,2TQRT@28211|Alphaproteobacteria 28211|Alphaproteobacteria I 2-nitropropane dioxygenase fabK - 1.3.1.9 ko:K02371 ko00061,ko01100,ko01212,map00061,map01100,map01212 M00083 R04429,R04724,R04955,R04958,R04961,R04966,R04969,R07765 RC00052,RC00076 ko00000,ko00001,ko00002,ko01000,ko01004 - - - NMO,ThiG k59_1396240_2 1122137.AQXF01000004_gene1847 5.62e-82 263.0 COG3605@1|root,COG3605@2|Bacteria,1QTTV@1224|Proteobacteria,2TR3Z@28211|Alphaproteobacteria 28211|Alphaproteobacteria T Belongs to the PEP-utilizing enzyme family ptsP - 2.7.3.9 ko:K08484 ko02060,map02060 - - - ko00000,ko00001,ko01000,ko02000 - - - GAF,GAF_2,PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C k59_1056301_1 1223523.H340_23448 5.29e-15 74.7 COG1024@1|root,COG1024@2|Bacteria,2GJDK@201174|Actinobacteria 201174|Actinobacteria I Enoyl-CoA hydratase chcB - 5.3.3.18 ko:K15866 ko00360,ko01120,map00360,map01120 - R09837,R09839 RC00004,RC00326,RC02689,RC03003 ko00000,ko00001,ko01000 - - - ECH_1 k59_1056301_2 1380390.JIAT01000013_gene276 6.73e-61 210.0 COG1703@1|root,COG1884@1|root,COG2185@1|root,COG1703@2|Bacteria,COG1884@2|Bacteria,COG2185@2|Bacteria,2GM65@201174|Actinobacteria,4CS56@84995|Rubrobacteria 84995|Rubrobacteria EI ArgK protein - - 5.4.99.13 ko:K11942 - - - - ko00000,ko01000 - - - ArgK,B12-binding,MM_CoA_mutase k59_264913_1 439235.Dalk_3439 1.24e-18 89.4 COG0373@1|root,COG0373@2|Bacteria,1MU41@1224|Proteobacteria,42MUG@68525|delta/epsilon subdivisions,2WISB@28221|Deltaproteobacteria,2MIIU@213118|Desulfobacterales 28221|Deltaproteobacteria H Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) hemA - 1.2.1.70 ko:K02492 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R04109 RC00055,RC00149 ko00000,ko00001,ko00002,ko01000 - - - GlutR_N,GlutR_dimer,Shikimate_DH k59_264913_2 1209989.TepiRe1_0508 1.86e-63 206.0 COG0181@1|root,COG0181@2|Bacteria,1TPFQ@1239|Firmicutes,2494Z@186801|Clostridia,42G48@68295|Thermoanaerobacterales 186801|Clostridia H Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps hemC - 2.5.1.61 ko:K01749 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R00084 RC02317 ko00000,ko00001,ko00002,ko01000 - - iHN637.CLJU_RS15760 Porphobil_deam,Porphobil_deamC k59_1277428_1 1122137.AQXF01000006_gene781 1.27e-50 171.0 COG0232@1|root,COG0232@2|Bacteria,1MVQ2@1224|Proteobacteria,2TRCD@28211|Alphaproteobacteria 28211|Alphaproteobacteria F Belongs to the dGTPase family. Type 2 subfamily dgt GO:0003674,GO:0003824,GO:0006139,GO:0006163,GO:0006195,GO:0006203,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008832,GO:0009056,GO:0009058,GO:0009117,GO:0009141,GO:0009143,GO:0009144,GO:0009146,GO:0009151,GO:0009155,GO:0009166,GO:0009200,GO:0009204,GO:0009215,GO:0009217,GO:0009262,GO:0009264,GO:0009394,GO:0009987,GO:0016787,GO:0016788,GO:0016793,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042578,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046070,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576 3.1.5.1 ko:K01129 ko00230,map00230 - R01856 RC00017 ko00000,ko00001,ko01000 - - - HD,HD_assoc k59_1277428_2 1122137.AQXF01000006_gene780 5.83e-43 154.0 COG0018@1|root,COG0018@2|Bacteria,1MU4J@1224|Proteobacteria,2TS3Y@28211|Alphaproteobacteria 28211|Alphaproteobacteria J Arginyl-tRNA synthetase argS - 6.1.1.19 ko:K01887 ko00970,map00970 M00359,M00360 R03646 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d k59_541667_1 436308.Nmar_0055 1.19e-113 345.0 COG1293@1|root,arCOG01695@2157|Archaea,41SB0@651137|Thaumarchaeota 651137|Thaumarchaeota K Fibronectin-binding protein A N-terminus (FbpA) - - - - - - - - - - - - DUF814,FbpA k59_614427_1 1122137.AQXF01000003_gene2421 9.45e-101 296.0 COG0288@1|root,COG0288@2|Bacteria,1NGFN@1224|Proteobacteria,2TRPD@28211|Alphaproteobacteria 28211|Alphaproteobacteria P Reversible hydration of carbon dioxide cynT - 4.2.1.1 ko:K01673 ko00910,map00910 - R00132,R10092 RC02807 ko00000,ko00001,ko01000 - - - Pro_CA k59_614427_2 1122137.AQXF01000003_gene2417 1.92e-50 177.0 COG2234@1|root,COG2234@2|Bacteria,1NVWC@1224|Proteobacteria 1224|Proteobacteria S Peptidase family M28 - - - - - - - - - - - - Peptidase_M28 k59_777850_1 1088721.NSU_1240 6.28e-112 356.0 COG5276@1|root,COG5276@2|Bacteria,1R66X@1224|Proteobacteria,2U4DF@28211|Alphaproteobacteria,2K18I@204457|Sphingomonadales 204457|Sphingomonadales S LVIVD repeat - - - - - - - - - - - - LVIVD k59_1004114_1 1303518.CCALI_00669 4.28e-24 107.0 COG3119@1|root,COG3119@2|Bacteria 2|Bacteria P arylsulfatase activity - - - - - - - - - - - - DUF4976,Glyco_tranf_2_3,Glycos_transf_2,Sulfatase k59_1684070_1 1121933.AUHH01000039_gene1593 6.19e-37 141.0 COG1007@1|root,COG1007@2|Bacteria,2GMGX@201174|Actinobacteria,4DNIM@85009|Propionibacteriales 201174|Actinobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoN GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 1.6.5.3 ko:K00343 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Proton_antipo_M k59_1518604_1 316407.85676247 5.19e-34 122.0 COG1587@1|root,COG1587@2|Bacteria,1MWZD@1224|Proteobacteria,1RM9K@1236|Gammaproteobacteria,3XNU7@561|Escherichia 1236|Gammaproteobacteria H synthase hemD GO:0003674,GO:0003824,GO:0004852,GO:0006725,GO:0006778,GO:0006779,GO:0006782,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046483,GO:0046501,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.2.1.75 ko:K01719 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R03165 RC01861 ko00000,ko00001,ko00002,ko01000 - - iJN746.PP_0187,iSBO_1134.SBO_3815 HEM4 k59_1518604_2 199310.c4722 7.51e-43 151.0 COG2959@1|root,COG2959@2|Bacteria,1MY3A@1224|Proteobacteria,1RNJY@1236|Gammaproteobacteria,3XMMF@561|Escherichia 1236|Gammaproteobacteria H HemX, putative uroporphyrinogen-III C-methyltransferase hemX - 2.1.1.107,4.2.1.75 ko:K02496,ko:K13543 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R03165,R03194 RC00003,RC00871,RC01861 ko00000,ko00001,ko00002,ko01000 - - iAF1260.b3803,iBWG_1329.BWG_3482,iECDH1ME8569_1439.ECDH1ME8569_3682,iECUMN_1333.ECUMN_4327,iECs_1301.ECs4733,iEcDH1_1363.EcDH1_4176,iJO1366.b3803,iJR904.b3803,iUMN146_1321.UM146_19140,iY75_1357.Y75_RS18060,iZ_1308.Z5317 HEM4,HemX k59_159381_1 316407.1651557 2.95e-27 108.0 COG0642@1|root,COG2205@2|Bacteria,1QTVU@1224|Proteobacteria,1RPFY@1236|Gammaproteobacteria,3XMJ7@561|Escherichia 1236|Gammaproteobacteria T adaptation to low Mg(2 ) environments and the control of acid resistance genes. In low periplasmic Mg(2 ), PhoQ functions as a membrane-associated protein kinase that undergoes autophosphorylation and subsequently transfers the phosphate to PhoP, resulting in the expression of PhoP-activated genes (PAG) and repression of PhoP-repressed genes (PRG). In high periplasmic Mg(2 ), acts as a protein phosphatase that dephosphorylates phospho-PhoP phoQ GO:0000155,GO:0000160,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0004721,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006464,GO:0006468,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0010350,GO:0016020,GO:0016021,GO:0016301,GO:0016310,GO:0016311,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0016787,GO:0016788,GO:0016791,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0023014,GO:0023052,GO:0031224,GO:0031226,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0035556,GO:0036211,GO:0042578,GO:0042594,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0046777,GO:0046872,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0071496,GO:0071704,GO:0071944,GO:0140096,GO:1901564 2.7.13.3 ko:K07637 ko01503,ko02020,map01503,map02020 M00444,M00709,M00721,M00723,M00724,M00744 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko01504,ko02022 - - - HATPase_c,HisKA,PhoQ_Sensor k59_159381_2 199310.c1480 1.77e-124 361.0 COG2850@1|root,COG2850@2|Bacteria,1MW30@1224|Proteobacteria,1RN2Q@1236|Gammaproteobacteria,3XN3B@561|Escherichia 1236|Gammaproteobacteria S peptidyl-arginine hydroxylation ycfD GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0008198,GO:0009987,GO:0016491,GO:0016705,GO:0016706,GO:0018193,GO:0018195,GO:0019538,GO:0030961,GO:0036211,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043687,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0046872,GO:0046914,GO:0051213,GO:0055114,GO:0071704,GO:1901564 1.14.11.47 ko:K18850 - - - - ko00000,ko01000,ko03009 - - - Cupin_4 k59_948487_1 1209072.ALBT01000030_gene2276 7.54e-20 81.6 COG2835@1|root,COG2835@2|Bacteria,1N6Y2@1224|Proteobacteria,1SCFF@1236|Gammaproteobacteria,1FIEC@10|Cellvibrio 1236|Gammaproteobacteria S Trm112p-like protein ycaR GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - ko:K09791 - - - - ko00000 - - - Trm112p k59_948487_2 1415778.JQMM01000001_gene2207 1.41e-53 170.0 COG0537@1|root,COG0537@2|Bacteria,1RDCJ@1224|Proteobacteria,1S3QE@1236|Gammaproteobacteria,1J6KQ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria FG Scavenger mRNA decapping enzyme C-term binding - - - ko:K02503 - - - - ko00000,ko04147 - - - HIT k59_389365_1 661478.OP10G_3225 6.6e-06 53.1 COG1063@1|root,COG1063@2|Bacteria 2|Bacteria E alcohol dehydrogenase adh - 1.1.1.14 ko:K00008 ko00040,ko00051,ko01100,map00040,map00051,map01100 M00014 R00875,R01896 RC00085,RC00102 ko00000,ko00001,ko00002,ko01000 - - - ADH_N,ADH_zinc_N k59_216606_1 199310.c1668 1.4e-26 106.0 COG0373@1|root,COG0373@2|Bacteria,1MU41@1224|Proteobacteria,1RNQ8@1236|Gammaproteobacteria,3XMMM@561|Escherichia 1236|Gammaproteobacteria H Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) hemA GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006082,GO:0006520,GO:0006536,GO:0006725,GO:0006778,GO:0006779,GO:0006782,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0008883,GO:0009058,GO:0009064,GO:0009987,GO:0016491,GO:0016620,GO:0016903,GO:0018130,GO:0019353,GO:0019438,GO:0019752,GO:0033013,GO:0033014,GO:0033526,GO:0034641,GO:0042168,GO:0042440,GO:0042802,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046148,GO:0046483,GO:0046501,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0140098,GO:0140101,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 1.2.1.70 ko:K02492 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R04109 RC00055,RC00149 ko00000,ko00001,ko00002,ko01000 - - iECNA114_1301.ECNA114_1375,iECSF_1327.ECSF_1186,iUTI89_1310.UTI89_C1404 GlutR_N,GlutR_dimer,Shikimate_DH k59_216606_2 316407.1651599 3.83e-24 95.5 COG3017@1|root,COG3017@2|Bacteria,1N02T@1224|Proteobacteria,1S91E@1236|Gammaproteobacteria,3XNXQ@561|Escherichia 1236|Gammaproteobacteria M Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein lolB GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0006807,GO:0008104,GO:0008150,GO:0008152,GO:0008289,GO:0009279,GO:0010876,GO:0016020,GO:0019538,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0033036,GO:0033218,GO:0034613,GO:0042157,GO:0042277,GO:0043170,GO:0044238,GO:0044462,GO:0044464,GO:0044872,GO:0044873,GO:0044874,GO:0051179,GO:0051641,GO:0051668,GO:0070727,GO:0071704,GO:0071723,GO:0071944,GO:0072657,GO:1901564 - ko:K02494 - - - - ko00000 - - - LolB k59_1065448_2 1122137.AQXF01000004_gene1622 4.64e-33 116.0 COG0633@1|root,COG0633@2|Bacteria,1N261@1224|Proteobacteria,2UC7B@28211|Alphaproteobacteria 28211|Alphaproteobacteria C ferredoxin - - - - - - - - - - - - Fer2 k59_1177011_1 330214.NIDE1635 4.15e-61 199.0 COG0117@1|root,COG1985@1|root,COG0117@2|Bacteria,COG1985@2|Bacteria,3J0H2@40117|Nitrospirae 40117|Nitrospirae H Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate ribD - 1.1.1.193,3.5.4.26 ko:K11752 ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024 M00125 R03458,R03459 RC00204,RC00933 ko00000,ko00001,ko00002,ko01000 - - - RibD_C,dCMP_cyt_deam_1 k59_1177011_2 330214.NIDE1634 7.65e-63 214.0 COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,3J101@40117|Nitrospirae 40117|Nitrospirae G Belongs to the PEP-utilizing enzyme family ppdK - 2.7.9.1 ko:K01006 ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200 M00169,M00171,M00172,M00173 R00206 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - PEP-utilizers,PEP-utilizers_C,PPDK_N k59_1576054_1 350054.Mflv_1096 2.34e-87 272.0 COG2807@1|root,COG2807@2|Bacteria,2HPRT@201174|Actinobacteria,23B02@1762|Mycobacteriaceae 201174|Actinobacteria P Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 k59_440294_1 46429.BV95_03390 5.83e-48 165.0 COG2267@1|root,COG2267@2|Bacteria,1QU7K@1224|Proteobacteria,2TW27@28211|Alphaproteobacteria,2K8PJ@204457|Sphingomonadales 204457|Sphingomonadales I Serine aminopeptidase, S33 - - - - - - - - - - - - Abhydrolase_1 k59_440294_2 1122137.AQXF01000005_gene1082 1.79e-06 48.9 COG1231@1|root,COG1231@2|Bacteria,1QXX6@1224|Proteobacteria 1224|Proteobacteria E K COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit - - 1.5.99.6 ko:K00316 ko00330,ko00410,ko01100,map00330,map00410,map01100 - R01914,R01915 RC00053,RC00225 ko00000,ko00001,ko01000 - - - NAD_binding_8 k59_614451_1 1207076.ALAT01000036_gene4158 9.46e-75 237.0 COG0516@1|root,COG0517@1|root,COG0516@2|Bacteria,COG0517@2|Bacteria,1MUJM@1224|Proteobacteria,1RMT8@1236|Gammaproteobacteria,1Z1NZ@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria F Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth guaB GO:0003674,GO:0003824,GO:0003938,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006183,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009314,GO:0009411,GO:0009416,GO:0009628,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046039,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0050896,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 1.1.1.205 ko:K00088 ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 M00050 R01130,R08240 RC00143,RC02207 ko00000,ko00001,ko00002,ko01000,ko04147 - - iAPECO1_1312.APECO1_4018,iECABU_c1320.ECABU_c28100,iECP_1309.ECP_2510,iECSF_1327.ECSF_2349,iUTI89_1310.UTI89_C2826,ic_1306.c3027 CBS,IMPDH,NMO k59_159407_1 565045.NOR51B_2144 5.42e-30 120.0 COG0668@1|root,COG0668@2|Bacteria,1N596@1224|Proteobacteria,1RQZP@1236|Gammaproteobacteria,1J7VP@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M COG0668 Small-conductance mechanosensitive channel VP2168 - - ko:K03442 - - - - ko00000,ko02000 1.A.23.2 - - MS_channel k59_1177027_1 688270.Celal_0104 7.24e-108 332.0 COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,4NF9D@976|Bacteroidetes,1HY3C@117743|Flavobacteriia,1F7WM@104264|Cellulophaga 976|Bacteroidetes I 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain fadN - 1.1.1.35 ko:K07516 ko00071,ko00362,ko00650,ko01100,ko01120,ko01200,ko01212,map00071,map00362,map00650,map01100,map01120,map01200,map01212 M00087 R01975,R04737,R04739,R04741,R04743,R04745,R04748,R05305 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000 - - - 3HCDH,3HCDH_N,ECH_1 k59_1576076_1 999550.KI421507_gene2421 1.43e-45 155.0 COG1235@1|root,COG1235@2|Bacteria,1MVJH@1224|Proteobacteria,2TQQN@28211|Alphaproteobacteria 28211|Alphaproteobacteria S COG1235 Metal-dependent hydrolases of the beta-lactamase superfamily I phnP - 3.1.4.55 ko:K06167 ko00440,map00440 - R10205 RC00296 ko00000,ko00001,ko01000 - - - Lactamase_B_2 k59_1576076_2 279714.FuraDRAFT_1314 0.000142 44.3 COG0084@1|root,COG0084@2|Bacteria,1MUC0@1224|Proteobacteria,2VHCT@28216|Betaproteobacteria,2KPUH@206351|Neisseriales 206351|Neisseriales L hydrolase, TatD family ycfH - - ko:K03424 - - - - ko00000,ko01000 - - - TatD_DNase k59_727654_1 398767.Glov_0002 1.32e-66 219.0 COG0592@1|root,COG0592@2|Bacteria,1MVD9@1224|Proteobacteria,42NQW@68525|delta/epsilon subdivisions,2WJZM@28221|Deltaproteobacteria,43T1D@69541|Desulfuromonadales 28221|Deltaproteobacteria L Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria dnaN - 2.7.7.7 ko:K02338 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_beta,DNA_pol3_beta_2,DNA_pol3_beta_3 k59_1232992_1 204773.HEAR3112 1.17e-30 125.0 COG2304@1|root,COG3419@1|root,COG2304@2|Bacteria,COG3419@2|Bacteria,1NUAV@1224|Proteobacteria,2VHY8@28216|Betaproteobacteria,472QP@75682|Oxalobacteraceae 28216|Betaproteobacteria NU Neisseria PilC beta-propeller domain pilY1 - - ko:K02674 - - - - ko00000,ko02035,ko02044 - - - Neisseria_PilC k59_666667_1 1131814.JAFO01000001_gene1976 1.35e-47 157.0 COG3427@1|root,COG3427@2|Bacteria,1RHUC@1224|Proteobacteria,2U9HD@28211|Alphaproteobacteria,3F1IG@335928|Xanthobacteraceae 28211|Alphaproteobacteria S Carbon monoxide dehydrogenase subunit G (CoxG) - - - ko:K09386 - - - - ko00000 - - - COXG k59_837337_1 1415754.JQMK01000013_gene202 8.91e-63 201.0 COG2003@1|root,COG2003@2|Bacteria,1MXZ5@1224|Proteobacteria,1RP86@1236|Gammaproteobacteria,466E7@72275|Alteromonadaceae 1236|Gammaproteobacteria E Belongs to the UPF0758 family radC GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360 - ko:K03630 - - - - ko00000 - - - RadC k59_777902_1 1121918.ARWE01000001_gene1837 3.71e-67 224.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,43UCF@69541|Desulfuromonadales 28221|Deltaproteobacteria T response regulator pilR - - ko:K02667 ko02020,map02020 M00501 - - ko00000,ko00001,ko00002,ko02022,ko02035 - - - HTH_8,Response_reg,Sigma54_activat k59_1457213_1 377629.TERTU_0102 1.62e-95 296.0 COG1164@1|root,COG1164@2|Bacteria,1MXAC@1224|Proteobacteria,1RPMX@1236|Gammaproteobacteria,2PPGS@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria E Oligopeptidase F pepF - - ko:K08602 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M3,Peptidase_M3_N k59_440307_1 383381.EH30_11420 8.88e-22 93.2 COG4395@1|root,COG4395@2|Bacteria,1NCIX@1224|Proteobacteria,2TTDQ@28211|Alphaproteobacteria,2K0UG@204457|Sphingomonadales 204457|Sphingomonadales S import inner membrane translocase, subunit Tim44 - - - - - - - - - - - - Tim44 k59_440307_2 754476.Q7A_20 5.76e-18 83.2 COG3030@1|root,COG3030@2|Bacteria,1MZJJ@1224|Proteobacteria,1S8XU@1236|Gammaproteobacteria,460ZE@72273|Thiotrichales 72273|Thiotrichales S FxsA cytoplasmic membrane protein - - - ko:K07113 - - - - ko00000 - - - FxsA k59_440307_3 1122137.AQXF01000001_gene3285 4.97e-95 281.0 COG1952@1|root,COG1952@2|Bacteria,1RI75@1224|Proteobacteria,2UBTB@28211|Alphaproteobacteria 28211|Alphaproteobacteria U One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA secB GO:0002790,GO:0006457,GO:0006810,GO:0008104,GO:0008150,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0032940,GO:0033036,GO:0042886,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0071702,GO:0071705 - ko:K03071 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044,ko03110 3.A.5 - - SecB k59_1457214_1 1122137.AQXF01000001_gene2742 3.66e-125 358.0 COG0302@1|root,COG0302@2|Bacteria,1MY3N@1224|Proteobacteria,2TSZI@28211|Alphaproteobacteria 28211|Alphaproteobacteria H GTP cyclohydrolase folE - 3.5.4.16 ko:K01495 ko00790,ko01100,map00790,map01100 M00126,M00841,M00842,M00843 R00428,R04639,R05046,R05048 RC00263,RC00294,RC00323,RC00945,RC01188 ko00000,ko00001,ko00002,ko01000 - - - GTP_cyclohydroI k59_49085_1 1280953.HOC_10009 1.98e-34 128.0 COG0104@1|root,COG0104@2|Bacteria,1MU5B@1224|Proteobacteria,2TRKY@28211|Alphaproteobacteria,43WXW@69657|Hyphomonadaceae 28211|Alphaproteobacteria F Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP purA GO:0003674,GO:0003824,GO:0004019,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046033,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.4.4 ko:K01939 ko00230,ko00250,ko01100,map00230,map00250,map01100 M00049 R01135 RC00458,RC00459 ko00000,ko00001,ko00002,ko01000 - - - Adenylsucc_synt k59_1065490_1 1112217.PPL19_11047 4.17e-50 174.0 COG1721@1|root,COG1721@2|Bacteria,1R3QD@1224|Proteobacteria,1S5F7@1236|Gammaproteobacteria 1236|Gammaproteobacteria S conserved protein (some members contain a von Willebrand factor type A (vWA) domain) - - - - - - - - - - - - DUF58 k59_389403_1 1192034.CAP_1628 7.97e-76 240.0 COG0205@1|root,COG0205@2|Bacteria,1R560@1224|Proteobacteria,42P6N@68525|delta/epsilon subdivisions,2WINA@28221|Deltaproteobacteria,2YVFG@29|Myxococcales 28221|Deltaproteobacteria H Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions pfp - 2.7.1.11,2.7.1.90 ko:K00895,ko:K21071 ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130 - R00756,R00764,R02073,R03236,R04779 RC00002,RC00017 ko00000,ko00001,ko01000 - - - PFK k59_1518658_1 1229909.NSED_04350 1e-43 156.0 COG0642@1|root,arCOG02358@2157|Archaea,41T5G@651137|Thaumarchaeota 651137|Thaumarchaeota T PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - HATPase_c,HisKA,dCache_1 k59_216642_1 436308.Nmar_0648 1.92e-37 133.0 COG1899@1|root,arCOG04142@2157|Archaea,41SDB@651137|Thaumarchaeota 651137|Thaumarchaeota O Deoxyhypusine synthase - - 2.5.1.46 ko:K00809 - - - - ko00000,ko01000 - - - DS k59_551376_1 1229909.NSED_02755 1.24e-48 157.0 COG1184@1|root,arCOG01127@2157|Archaea,41T2Z@651137|Thaumarchaeota 651137|Thaumarchaeota L NUDIX domain - - - - - - - - - - - - NUDIX k59_551376_2 1229909.NSED_02760 9.81e-133 384.0 COG0722@1|root,arCOG00245@2157|Archaea,41SM0@651137|Thaumarchaeota 651137|Thaumarchaeota E Prephenate dehydrogenase - - 1.3.1.12 ko:K04517 ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230 M00025 R01728 RC00125 ko00000,ko00001,ko00002,ko01000 - - - PDH k59_551376_3 1229909.NSED_02765 1.06e-75 239.0 COG0436@1|root,COG1605@1|root,arCOG01130@2157|Archaea,arCOG02098@2157|Archaea,41SBV@651137|Thaumarchaeota 651137|Thaumarchaeota E Chorismate mutase type II - - 2.6.1.1 ko:K00812 ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230 - R00355,R00694,R00734,R00896,R02433,R02619,R05052 RC00006 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_1_2,CM_2 k59_1576121_1 485915.Dret_0646 8.51e-60 197.0 COG3464@1|root,COG3464@2|Bacteria,1R4DH@1224|Proteobacteria,43AQ4@68525|delta/epsilon subdivisions,2X63W@28221|Deltaproteobacteria,2MGXP@213115|Desulfovibrionales 28221|Deltaproteobacteria L PFAM transposase IS204 IS1001 IS1096 IS1165 family protein - - - - - - - - - - - - DDE_Tnp_ISL3,zf-ISL3 k59_105032_1 1131462.DCF50_p326 1.31e-96 319.0 COG1197@1|root,COG1197@2|Bacteria,1TPF1@1239|Firmicutes,248D8@186801|Clostridia,2600Y@186807|Peptococcaceae 186801|Clostridia L Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site mfd - - ko:K03723 ko03420,map03420 - - - ko00000,ko00001,ko01000,ko03400 - - - CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF k59_216665_1 883126.HMPREF9710_04567 1.96e-54 183.0 COG4952@1|root,COG4952@2|Bacteria,1PSSV@1224|Proteobacteria,2VNT0@28216|Betaproteobacteria,472DW@75682|Oxalobacteraceae 28216|Betaproteobacteria G Xylose isomerase-like TIM barrel - - 5.3.1.14 ko:K01820 ko00040,ko00051,ko01120,map00040,map00051,map01120 - R01906,R02437,R06589 RC00376,RC00434,RC00516 ko00000,ko00001,ko01000 - - - AP_endonuc_2 k59_216665_2 1121028.ARQE01000006_gene4396 1.55e-20 90.5 COG1028@1|root,COG3347@1|root,COG1028@2|Bacteria,COG3347@2|Bacteria,1MWSB@1224|Proteobacteria,2TSSM@28211|Alphaproteobacteria,2PJ60@255475|Aurantimonadaceae 28211|Alphaproteobacteria IQ Class II Aldolase and Adducin N-terminal domain rhaD - - - - - - - - - - - Aldolase_II,adh_short_C2 k59_1741341_1 1122194.AUHU01000008_gene3398 6.62e-83 274.0 COG1629@1|root,COG1629@2|Bacteria,COG4771@2|Bacteria,1MUWN@1224|Proteobacteria,1RRR7@1236|Gammaproteobacteria,464TZ@72275|Alteromonadaceae 1236|Gammaproteobacteria P TonB dependent receptor - - - - - - - - - - - - Plug,TonB_dep_Rec k59_727687_1 498211.CJA_3194 1.42e-170 501.0 COG0542@1|root,COG0542@2|Bacteria,1MURH@1224|Proteobacteria,1RN55@1236|Gammaproteobacteria,1FGCP@10|Cellvibrio 1236|Gammaproteobacteria O Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE clpB GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0006950,GO:0006986,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009266,GO:0009408,GO:0009628,GO:0010033,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030554,GO:0031249,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0035966,GO:0036094,GO:0042221,GO:0042623,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564 - ko:K03695 ko04213,map04213 - - - ko00000,ko00001,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N k59_495804_1 886377.Murru_0599 5.36e-109 329.0 COG1069@1|root,COG1069@2|Bacteria,4NEFQ@976|Bacteroidetes,1HZHT@117743|Flavobacteriia 976|Bacteroidetes G Belongs to the ribulokinase family araB - 2.7.1.16 ko:K00853 ko00040,ko01100,map00040,map01100 - R01526,R02439 RC00002,RC00538 ko00000,ko00001,ko01000 - - - FGGY_C,FGGY_N k59_1287507_2 1459636.NTE_03247 1.21e-66 219.0 COG3608@1|root,arCOG02889@2157|Archaea 2157|Archaea S Succinylglutamate desuccinylase aspartoacylase - - - ko:K06987 - - - - ko00000 - - - AstE_AspA,Peptidase_M14 k59_389437_1 379066.GAU_1623 7.18e-39 140.0 COG2877@1|root,COG2877@2|Bacteria,1ZUCD@142182|Gemmatimonadetes 142182|Gemmatimonadetes M DAHP synthetase I family - - 2.5.1.55 ko:K01627 ko00540,ko01100,map00540,map01100 M00063 R03254 RC00435 ko00000,ko00001,ko00002,ko01000,ko01005 - - - DAHP_synth_1 k59_1118290_2 395493.BegalDRAFT_1677 1.4e-54 191.0 COG0542@1|root,COG0542@2|Bacteria,1MV8B@1224|Proteobacteria,1RMH3@1236|Gammaproteobacteria,45ZV1@72273|Thiotrichales 72273|Thiotrichales O ATP-dependent Clp protease ATP-binding subunit ClpA - - - ko:K03694 - - - - ko00000,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N k59_1457263_1 1234595.C725_2043 2.51e-12 66.2 COG0022@1|root,COG0022@2|Bacteria,1R8KB@1224|Proteobacteria,2TRMR@28211|Alphaproteobacteria,4BPHD@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria C The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) pdhB - 1.2.4.1 ko:K00162 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230 M00307 R00014,R00209,R01699,R03270 RC00004,RC00027,RC00627,RC02742,RC02744,RC02882 br01601,ko00000,ko00001,ko00002,ko01000 - - - Biotin_lipoyl,Transket_pyr,Transketolase_C k59_1457263_2 1122137.AQXF01000002_gene167 3.96e-43 154.0 COG0508@1|root,COG0508@2|Bacteria,1MUGY@1224|Proteobacteria,2TRXM@28211|Alphaproteobacteria 28211|Alphaproteobacteria C The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) pdhC - 1.2.4.1,2.3.1.12 ko:K00162,ko:K00627 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230 M00307 R00014,R00209,R01699,R02569,R03270 RC00004,RC00027,RC00627,RC02742,RC02744,RC02857,RC02882 br01601,ko00000,ko00001,ko00002,ko01000 - - - 2-oxoacid_dh,Biotin_lipoyl,E3_binding k59_777965_1 469383.Cwoe_4215 1.08e-83 256.0 COG0074@1|root,COG0074@2|Bacteria,2GK00@201174|Actinobacteria 201174|Actinobacteria C Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit sucD GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944 6.2.1.5 ko:K01902 ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374,M00620 R00405,R02404 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000 - - - CoA_binding,Ligase_CoA k59_1287520_1 203122.Sde_1256 3.8e-70 234.0 COG0249@1|root,COG0249@2|Bacteria,1MUGX@1224|Proteobacteria,1RNW3@1236|Gammaproteobacteria,464F1@72275|Alteromonadaceae 1236|Gammaproteobacteria L that it carries out the mismatch recognition step. This protein has a weak ATPase activity mutS GO:0000018,GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0008301,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019219,GO:0019222,GO:0030554,GO:0030983,GO:0031323,GO:0032136,GO:0032300,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033554,GO:0034641,GO:0035639,GO:0036094,GO:0042623,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0043531,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051171,GO:0051716,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901363,GO:1990391 - ko:K03555 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - iECW_1372.ECW_m2935,iWFL_1372.ECW_m2935 MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V k59_440360_2 52598.EE36_13848 2.1e-17 80.1 COG0351@1|root,COG0351@2|Bacteria,1MU9J@1224|Proteobacteria,2TUKR@28211|Alphaproteobacteria,3ZX0Y@60136|Sulfitobacter 28211|Alphaproteobacteria H Phosphomethylpyrimidine kinase thiD - 2.7.1.49,2.7.4.7 ko:K00941 ko00730,ko01100,map00730,map01100 M00127 R03471,R04509 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - Phos_pyr_kin k59_49119_1 1396418.BATQ01000189_gene762 2.77e-55 188.0 COG3344@1|root,COG3344@2|Bacteria,46TQ6@74201|Verrucomicrobia 74201|Verrucomicrobia L PFAM RNA-directed DNA polymerase (Reverse transcriptase) - - - - - - - - - - - - GIIM,RVT_1 k59_666715_2 95619.PM1_0204215 3.17e-72 228.0 COG0042@1|root,COG0042@2|Bacteria,1MV5V@1224|Proteobacteria,1RMJP@1236|Gammaproteobacteria 1236|Gammaproteobacteria J Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines dusB GO:0002943,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009314,GO:0009451,GO:0009628,GO:0009987,GO:0010467,GO:0016070,GO:0016491,GO:0016627,GO:0017150,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0050896,GO:0055114,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 - ko:K05540 - - - - ko00000,ko01000,ko03016 - - - Dus k59_727704_1 317655.Sala_1550 1.27e-61 194.0 COG1051@1|root,COG1051@2|Bacteria,1QU0T@1224|Proteobacteria,2TW25@28211|Alphaproteobacteria,2K4S3@204457|Sphingomonadales 204457|Sphingomonadales F Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage nudH - - ko:K08311 ko03018,map03018 - R10816 RC00002 ko00000,ko00001,ko01000,ko03019 - - - NUDIX k59_1684180_1 314260.PB2503_13039 1.52e-44 164.0 COG5426@1|root,COG5426@2|Bacteria,1MVWA@1224|Proteobacteria,2TQNQ@28211|Alphaproteobacteria 28211|Alphaproteobacteria S membrane MA20_44660 - - - - - - - - - - - GATase1_like k59_1233043_1 685778.AORL01000021_gene314 6.95e-25 103.0 COG5621@1|root,COG5621@2|Bacteria,1MUVF@1224|Proteobacteria,2TSVN@28211|Alphaproteobacteria,2K200@204457|Sphingomonadales 204457|Sphingomonadales S Lipocalin-like domain - - - - - - - - - - - - CrtC,Lipocalin_9 k59_1233043_2 1249627.D779_2093 7.41e-19 85.9 COG0577@1|root,COG4591@1|root,COG0577@2|Bacteria,COG4591@2|Bacteria,1MVCT@1224|Proteobacteria,1RNP1@1236|Gammaproteobacteria,1WWFF@135613|Chromatiales 135613|Chromatiales V ABC-type transport system, involved in lipoprotein release, permease component - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_1177093_1 66875.JODY01000003_gene3732 7.29e-06 55.1 COG0642@1|root,COG2205@2|Bacteria,2GK1J@201174|Actinobacteria 201174|Actinobacteria T Histidine kinase - - 2.7.13.3 ko:K07654 ko02020,map02020 M00461 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,HisKA k59_332379_1 1121374.KB891586_gene2862 1.48e-79 245.0 COG3958@1|root,COG3958@2|Bacteria,1N6QF@1224|Proteobacteria,1RYXD@1236|Gammaproteobacteria 1236|Gammaproteobacteria G Transketolase - - 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 - - - Transket_pyr,Transketolase_C k59_332379_2 1122137.AQXF01000006_gene705 5.28e-69 216.0 COG3959@1|root,COG3959@2|Bacteria,1MWRX@1224|Proteobacteria,2TRA2@28211|Alphaproteobacteria 28211|Alphaproteobacteria G Transketolase tktB - 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 - - - Transketolase_N k59_552405_2 316407.85675548 1.71e-99 294.0 COG0378@1|root,COG0378@2|Bacteria,1MVBD@1224|Proteobacteria,1RN9Y@1236|Gammaproteobacteria,3XNGB@561|Escherichia 1236|Gammaproteobacteria KO Required for the maturation of the three NiFe hydrogenases. Exhibits a low intrinsic GTPase activity. The GTP hydrolysis catalyzed by HypB is an integral process in the incorporation of nickel into hydrogenases hypB GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009987,GO:0010467,GO:0016151,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0019538,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0051604,GO:0071704,GO:1901564 - ko:K04652 - - - - ko00000,ko03110 - - - cobW k59_667692_1 877421.AUJT01000031_gene3594 0.00054 49.3 COG3250@1|root,COG3250@2|Bacteria,1TS9P@1239|Firmicutes,24C3W@186801|Clostridia,27IEG@186928|unclassified Lachnospiraceae 186801|Clostridia G beta-galactosidase activity - - - - - - - - - - - - Glyco_hydro_106,Glyco_hydro_2_N k59_667692_2 1048983.EL17_22070 4.15e-21 91.7 2BZ6M@1|root,2Z7HW@2|Bacteria,4NDZE@976|Bacteroidetes,47M8V@768503|Cytophagia 976|Bacteroidetes S Domain of Unknown Function (DUF1080) - - - - - - - - - - - - DUF1080 k59_898770_1 551789.ATVJ01000001_gene988 4.11e-25 106.0 COG0508@1|root,COG0508@2|Bacteria,1MUJD@1224|Proteobacteria,2TS5N@28211|Alphaproteobacteria,43WUZ@69657|Hyphomonadaceae 28211|Alphaproteobacteria C The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) sucB - 2.3.1.61 ko:K00658 ko00020,ko00310,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00032 R02570,R02571,R08549 RC00004,RC02727,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - 2-oxoacid_dh,Biotin_lipoyl,E3_binding k59_898770_2 1122137.AQXF01000007_gene3515 3.89e-71 237.0 COG0567@1|root,COG0567@2|Bacteria,1MVBF@1224|Proteobacteria,2TRBQ@28211|Alphaproteobacteria 28211|Alphaproteobacteria C COG0567 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes sucA - 1.2.4.2 ko:K00164 ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00032 R00621,R01933,R01940,R03316,R08549 RC00004,RC00027,RC00627,RC02743,RC02833,RC02883 br01601,ko00000,ko00001,ko00002,ko01000 - - - 2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr k59_898773_1 1122137.AQXF01000002_gene22 1.71e-47 176.0 COG0457@1|root,COG0457@2|Bacteria,1PDUB@1224|Proteobacteria,2TTYN@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Tetratricopeptide repeat - - - - - - - - - - - - TPR_16,TPR_19,TPR_21 k59_1458233_1 420662.Mpe_A1223 5.59e-64 201.0 2B4XH@1|root,31XQC@2|Bacteria,1RHJF@1224|Proteobacteria,2W1BJ@28216|Betaproteobacteria,1KNAC@119065|unclassified Burkholderiales 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_1344786_1 118173.KB235910_gene4402 0.000104 50.1 COG3774@1|root,COG3774@2|Bacteria,1GFKE@1117|Cyanobacteria 1117|Cyanobacteria M Capsular polysaccharide synthesis protein - - - - - - - - - - - - Caps_synth k59_1178187_1 1408442.JADE01000005_gene1353 5.63e-20 84.7 2E0TJ@1|root,32WB7@2|Bacteria,1N6XI@1224|Proteobacteria,42XT2@68525|delta/epsilon subdivisions,2YQYU@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria - - - - - - - - - - - - - - - k59_1178187_2 395494.Galf_2501 4.83e-28 113.0 COG0591@1|root,COG0591@2|Bacteria,1MUBI@1224|Proteobacteria,2VHA8@28216|Betaproteobacteria,44V0T@713636|Nitrosomonadales 28216|Betaproteobacteria E Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family putP - - ko:K14392 - - - - ko00000,ko02000 2.A.21.1 - - SSF k59_1458236_1 998674.ATTE01000001_gene1696 6.61e-93 283.0 COG0538@1|root,COG0538@2|Bacteria,1MW3J@1224|Proteobacteria,1RNMD@1236|Gammaproteobacteria,4623N@72273|Thiotrichales 72273|Thiotrichales C Isocitrate/isopropylmalate dehydrogenase - - 1.1.1.42 ko:K00031 ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146 M00009,M00010,M00173,M00740 R00267,R00268,R01899 RC00001,RC00084,RC00114,RC00626,RC02801 br01601,ko00000,ko00001,ko00002,ko01000 - - - Iso_dh k59_1685246_1 1096930.L284_23400 4.66e-22 90.9 2B5IK@1|root,31YDD@2|Bacteria,1RAZF@1224|Proteobacteria,2U6F0@28211|Alphaproteobacteria,2K43H@204457|Sphingomonadales 204457|Sphingomonadales - - - - - - - - - - - - - - - k59_1685246_2 1088721.NSU_0641 4.83e-100 297.0 COG0761@1|root,COG0761@2|Bacteria,1MU7G@1224|Proteobacteria,2TRNR@28211|Alphaproteobacteria,2K1ES@204457|Sphingomonadales 204457|Sphingomonadales IM Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis ispH - 1.17.7.4 ko:K03527 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05884,R08210 RC01137,RC01487 ko00000,ko00001,ko00002,ko01000 - - - LYTB k59_560424_1 626939.HMPREF9443_00374 4.98e-30 122.0 COG4942@1|root,COG4942@2|Bacteria,1TQ5I@1239|Firmicutes,4H1XM@909932|Negativicutes 909932|Negativicutes D Peptidase M23 envC_1 - - ko:K21471 - - - - ko00000,ko01000,ko01002,ko01011 - - - Peptidase_M23 k59_504539_1 1122137.AQXF01000007_gene3483 1.39e-52 181.0 COG2373@1|root,COG2373@2|Bacteria,1QV7E@1224|Proteobacteria 1224|Proteobacteria V TIGRFAM Outer membrane protein - - - ko:K13735,ko:K20276 ko02024,ko05100,map02024,map05100 - - - ko00000,ko00001 - - - Calx-beta,SWM_repeat,SdrD_B k59_1296590_2 267608.RSc2804 3.9e-116 342.0 COG0208@1|root,COG0208@2|Bacteria,1MWUS@1224|Proteobacteria,2VI7U@28216|Betaproteobacteria,1K06J@119060|Burkholderiaceae 28216|Betaproteobacteria F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides nrdB - 1.17.4.1 ko:K00526 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - Ribonuc_red_sm k59_1296594_1 436308.Nmar_1691 2.55e-136 400.0 COG1155@1|root,arCOG00868@2157|Archaea,41SZU@651137|Thaumarchaeota 651137|Thaumarchaeota F Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit atpA - 3.6.3.14,3.6.3.15 ko:K02117 ko00190,ko01100,map00190,map01100 M00159 - - ko00000,ko00001,ko00002,ko01000 3.A.2.2,3.A.2.3 - - ATP-synt_ab,ATP-synt_ab_N,ATP-synt_ab_Xtn k59_1296601_1 330214.NIDE0782 1.73e-44 153.0 COG1825@1|root,COG1825@2|Bacteria,3J0NK@40117|Nitrospirae 40117|Nitrospirae J This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance ctc GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02897 ko03010,map03010 M00178 - - ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L25p,Ribosomal_TL5_C k59_168495_1 237368.SCABRO_00745 1.81e-60 201.0 COG0477@1|root,COG2814@2|Bacteria 2|Bacteria EGP Major facilitator Superfamily ycaD - - - - - - - - - - - MFS_1,Sugar_tr k59_675501_1 593750.Metfor_1167 1.06e-27 117.0 COG0119@1|root,arCOG02092@2157|Archaea,2XSZJ@28890|Euryarchaeota,2N9FJ@224756|Methanomicrobia 224756|Methanomicrobia E Belongs to the alpha-IPM synthase homocitrate synthase family leuA - 2.3.3.13 ko:K01649 ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230 M00432 R01213 RC00004,RC00470,RC02754 br01601,ko00000,ko00001,ko00002,ko01000 - - - HMGL-like,LeuA_dimer k59_168504_1 247639.MGP2080_10983 1.29e-84 270.0 COG0326@1|root,COG0326@2|Bacteria,1MUUE@1224|Proteobacteria,1RNWD@1236|Gammaproteobacteria,1J4YG@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O Molecular chaperone. Has ATPase activity htpG GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006950,GO:0006974,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0033554,GO:0042623,GO:0042802,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716 - ko:K04079 ko04141,ko04151,ko04217,ko04612,ko04621,ko04626,ko04657,ko04659,ko04914,ko04915,ko05200,ko05215,ko05418,map04141,map04151,map04217,map04612,map04621,map04626,map04657,map04659,map04914,map04915,map05200,map05215,map05418 - - - ko00000,ko00001,ko01009,ko03029,ko03051,ko03110,ko04131,ko04147 - - - HATPase_c,HATPase_c_3,HSP90 k59_560465_1 316407.85675854 2.53e-147 440.0 COG1391@1|root,COG1391@2|Bacteria,1MU4I@1224|Proteobacteria,1RP9N@1236|Gammaproteobacteria,3XP8M@561|Escherichia 1236|Gammaproteobacteria H Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell glnE GO:0000166,GO:0000287,GO:0000820,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006521,GO:0006541,GO:0006542,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0008882,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0010565,GO:0016053,GO:0016740,GO:0016772,GO:0016779,GO:0017076,GO:0019222,GO:0019752,GO:0030554,GO:0031323,GO:0032553,GO:0032555,GO:0032559,GO:0033238,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046872,GO:0050789,GO:0050794,GO:0051171,GO:0062012,GO:0065007,GO:0070566,GO:0071704,GO:0080090,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.7.42,2.7.7.89 ko:K00982 - - - - ko00000,ko01000 - - - GlnD_UR_UTase,GlnE k59_1012990_1 316407.85677085 2.19e-124 360.0 COG4268@1|root,COG4268@2|Bacteria,1R1FP@1224|Proteobacteria,1RZIR@1236|Gammaproteobacteria 1236|Gammaproteobacteria V DNA restriction-modification system mcrC - - ko:K19147 - - - - ko00000,ko02048 - - - McrBC k59_168519_1 1089552.KI911559_gene390 8.67e-63 219.0 COG4581@1|root,COG4581@2|Bacteria,1MVD6@1224|Proteobacteria,2TR7N@28211|Alphaproteobacteria,2JQAB@204441|Rhodospirillales 204441|Rhodospirillales L COG0513 Superfamily II DNA and RNA helicases - - 3.6.4.13 ko:K17675 - - - - ko00000,ko01000,ko03029 - - - Helicase_C k59_675545_1 1122194.AUHU01000008_gene3286 5e-100 301.0 COG0019@1|root,COG0019@2|Bacteria,1MUA6@1224|Proteobacteria,1RMI2@1236|Gammaproteobacteria,4641G@72275|Alteromonadaceae 1236|Gammaproteobacteria E Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine lysA GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008836,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016829,GO:0016830,GO:0016831,GO:0019752,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046451,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.1.1.20 ko:K01586 ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R00451 RC00299 ko00000,ko00001,ko00002,ko01000 - - - Orn_Arg_deC_N,Orn_DAP_Arg_deC k59_1185904_1 1229909.NSED_05185 2.86e-97 292.0 COG1899@1|root,arCOG04142@2157|Archaea,41SWS@651137|Thaumarchaeota 651137|Thaumarchaeota O Deoxyhypusine synthase - - 2.5.1.46 ko:K00809 - - - - ko00000,ko01000 - - - DS k59_560490_1 744872.Spica_0968 3.49e-05 50.1 COG2204@1|root,COG2204@2|Bacteria,2J9VS@203691|Spirochaetes 203691|Spirochaetes T Bacterial regulatory protein, Fis family - - - - - - - - - - - - HTH_8,Response_reg,Sigma54_activat k59_1127537_1 1267533.KB906734_gene4005 0.000856 47.4 COG3710@1|root,COG5616@1|root,COG3710@2|Bacteria,COG5616@2|Bacteria 2|Bacteria S cAMP biosynthetic process - - - - - - - - - - - - TPR_11,TPR_16,TPR_19,TPR_8,Trans_reg_C k59_786964_1 485913.Krac_11896 8.95e-51 175.0 COG3872@1|root,COG3872@2|Bacteria,2G5XQ@200795|Chloroflexi 200795|Chloroflexi S Protein of unknown function (DUF1385) - - - ko:K09153 - - - - ko00000 - - - DUF1385 k59_1296655_2 1229909.NSED_08785 3.43e-39 132.0 COG2118@1|root,arCOG04179@2157|Archaea,41SR0@651137|Thaumarchaeota 651137|Thaumarchaeota S Belongs to the PDCD5 family - - - ko:K06875 - - - - ko00000 - - - dsDNA_bind k59_1242021_1 1123240.ATVO01000007_gene2176 1.41e-157 477.0 COG1014@1|root,COG4231@1|root,COG1014@2|Bacteria,COG4231@2|Bacteria,1MUKS@1224|Proteobacteria,2TSHH@28211|Alphaproteobacteria,2K2DM@204457|Sphingomonadales 204457|Sphingomonadales C PFAM pyruvate ferredoxin flavodoxin oxidoreductase - - 1.2.7.8 ko:K04090 - - - - br01601,ko00000,ko01000 - - - POR,TPP_enzyme_C k59_1242024_1 1449049.JONW01000007_gene4040 4.75e-17 85.9 COG1629@1|root,COG4771@2|Bacteria,1MUWN@1224|Proteobacteria,2TUIR@28211|Alphaproteobacteria 28211|Alphaproteobacteria P COG1629 Outer membrane receptor proteins, mostly Fe transport - - - - - - - - - - - - Plug,TonB_dep_Rec k59_786974_1 1207063.P24_08094 3.34e-28 111.0 COG2021@1|root,COG2021@2|Bacteria,1RDEH@1224|Proteobacteria,2U267@28211|Alphaproteobacteria,2JS8S@204441|Rhodospirillales 204441|Rhodospirillales E Alpha/beta hydrolase family - - - - - - - - - - - - Abhydrolase_1,Abhydrolase_6 k59_786974_2 1122137.AQXF01000002_gene94 1.09e-39 142.0 COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,2TR6Q@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Belongs to the DEAD box helicase family rhlE - 3.6.4.13 ko:K03732,ko:K11927 ko03018,map03018 M00394 - - ko00000,ko00001,ko00002,ko01000,ko03019 - - - DEAD,Helicase_C k59_1693516_1 946483.Cenrod_2547 2.32e-72 228.0 COG2801@1|root,COG2801@2|Bacteria,1MVC8@1224|Proteobacteria,2VMCK@28216|Betaproteobacteria 28216|Betaproteobacteria L HTH-like domain - - - ko:K07497 - - - - ko00000 - - - HTH_21,rve k59_675573_1 765914.ThisiDRAFT_1633 2.59e-56 186.0 COG0767@1|root,COG0767@2|Bacteria,1MVPN@1224|Proteobacteria,1RM9H@1236|Gammaproteobacteria,1WWID@135613|Chromatiales 135613|Chromatiales Q Permease MlaE - - - ko:K02066 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - MlaE k59_675573_2 243924.LT42_16120 1.74e-09 57.8 COG1127@1|root,COG1127@2|Bacteria,1MUSD@1224|Proteobacteria,1RMCJ@1236|Gammaproteobacteria 1236|Gammaproteobacteria Q (ABC) transporter mlaF GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0008144,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - ko:K02065 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - ABC_tran k59_957623_1 436308.Nmar_1798 3.72e-24 91.3 arCOG00818@1|root,arCOG00818@2157|Archaea 2157|Archaea S AbrB family - - - - - - - - - - - - MazE_antitoxin k59_957623_2 436308.Nmar_1799 3.09e-70 213.0 arCOG04038@1|root,arCOG04038@2157|Archaea,41SQU@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1802644_1 706587.Desti_0005 1.22e-31 119.0 COG0705@1|root,COG0705@2|Bacteria,1MYFP@1224|Proteobacteria,42P0V@68525|delta/epsilon subdivisions,2WJGR@28221|Deltaproteobacteria,2MRXV@213462|Syntrophobacterales 28221|Deltaproteobacteria S Rhomboid family - - - ko:K07059 - - - - ko00000 - - - DnaJ_C,Rhomboid k59_225818_1 1197477.IA57_12260 2.25e-111 358.0 COG2911@1|root,COG2911@2|Bacteria,4NF7F@976|Bacteroidetes,1HWKQ@117743|Flavobacteriia 976|Bacteroidetes S PFAM Family of - - - - - - - - - - - - TamB k59_1802646_1 926569.ANT_26970 4.11e-67 217.0 COG2010@1|root,COG2864@1|root,COG2010@2|Bacteria,COG2864@2|Bacteria 2|Bacteria C formate dehydrogenase - - - - - - - - - - - - Cytochrom_c3_2,Ni_hydr_CYTB,PSCyt1 k59_225821_1 1122137.AQXF01000002_gene520 4.1e-95 286.0 COG0119@1|root,COG0119@2|Bacteria,1MUMX@1224|Proteobacteria,2TT1R@28211|Alphaproteobacteria 28211|Alphaproteobacteria E hydroxy-methylglutaryl-CoA lyase - - 4.1.3.4 ko:K01640 ko00072,ko00280,ko00281,ko00650,ko01100,ko04146,map00072,map00280,map00281,map00650,map01100,map04146 M00036,M00088 R01360,R08090 RC00502,RC00503,RC01118,RC01946 ko00000,ko00001,ko00002,ko01000 - - - HMGL-like k59_1802648_1 555088.DealDRAFT_0085 5.61e-12 66.2 COG1725@1|root,COG1725@2|Bacteria,1V9ZC@1239|Firmicutes,24NTW@186801|Clostridia,42KP5@68298|Syntrophomonadaceae 186801|Clostridia K helix_turn_helix gluconate operon transcriptional repressor - - - ko:K07979 - - - - ko00000,ko03000 - - - GntR k59_675594_1 1088721.NSU_0249 4.49e-95 300.0 COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,2TR4E@28211|Alphaproteobacteria,2K15B@204457|Sphingomonadales 204457|Sphingomonadales O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner lon - 3.4.21.53 ko:K01338 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - AAA,LON_substr_bdg,Lon_C k59_1466332_1 269798.CHU_1557 5.62e-10 66.2 COG2152@1|root,COG3291@1|root,COG2152@2|Bacteria,COG3291@2|Bacteria,4PHTS@976|Bacteroidetes,47Q40@768503|Cytophagia 976|Bacteroidetes DZ regulator of chromosome condensation, RCC1 - - - - - - - - - - - - CHU_C k59_846727_1 237368.SCABRO_01641 2.69e-17 81.6 COG0500@1|root,COG1181@1|root,COG1181@2|Bacteria,COG2226@2|Bacteria,2IYQF@203682|Planctomycetes 203682|Planctomycetes M Belongs to the D-alanine--D-alanine ligase family - - 6.3.2.4 ko:K01921 ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502 - R01150 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Dala_Dala_lig_C k59_846727_2 1415754.JQMK01000005_gene1594 9.81e-08 53.5 293ZC@1|root,2ZREC@2|Bacteria,1RDYU@1224|Proteobacteria,1S4U7@1236|Gammaproteobacteria,467DI@72275|Alteromonadaceae 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_1185939_1 1088721.NSU_2415 2.32e-42 152.0 COG4372@1|root,COG4372@2|Bacteria,1MUCX@1224|Proteobacteria,2TR59@28211|Alphaproteobacteria,2KEBT@204457|Sphingomonadales 204457|Sphingomonadales L zinc-finger binding domain of transposase IS66 - - - - - - - - - - - - DDE_Tnp_IS66,DDE_Tnp_IS66_C,LZ_Tnp_IS66,zf-IS66 k59_1185939_2 1234595.C725_3051 1.12e-75 226.0 COG3436@1|root,COG3436@2|Bacteria,1RHDW@1224|Proteobacteria,2U7TH@28211|Alphaproteobacteria 28211|Alphaproteobacteria L IS66 Orf2 family protein - - - ko:K07484 - - - - ko00000 - - - TnpB_IS66 k59_957648_1 288000.BBta_4801 3.49e-15 80.5 COG0318@1|root,COG1020@1|root,COG0318@2|Bacteria,COG1020@2|Bacteria,1MU6G@1224|Proteobacteria,2TW3C@28211|Alphaproteobacteria,3K6MI@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria IQ Phosphopantetheine attachment site - - - - - - - - - - - - AMP-binding,AMP-binding_C,Condensation,PP-binding k59_1750318_1 383372.Rcas_1218 9.19e-42 153.0 COG1109@1|root,COG1109@2|Bacteria,2G5YP@200795|Chloroflexi,3756A@32061|Chloroflexia 32061|Chloroflexia G phosphoglucomutase phosphomannomutase alpha beta alpha domain I - - 5.4.2.8 ko:K01840 ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130 M00114 R01818 RC00408 ko00000,ko00001,ko00002,ko01000 - - - PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV k59_1296755_1 908338.HMPREF9286_0985 0.000976 43.5 COG1226@1|root,COG3273@1|root,COG1226@2|Bacteria,COG3273@2|Bacteria,1V2CY@1239|Firmicutes,24DT6@186801|Clostridia,22FZT@1570339|Peptoniphilaceae 186801|Clostridia P TrkA N-terminal domain protein - - - ko:K10716 - - - - ko00000,ko02000 1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6 - - Ion_trans_2,TrkA_C,TrkA_N k59_1296755_2 643867.Ftrac_3401 1.27e-10 62.4 COG1259@1|root,COG3880@1|root,COG1259@2|Bacteria,COG3880@2|Bacteria,4NGSW@976|Bacteroidetes,47KJI@768503|Cytophagia 976|Bacteroidetes L PFAM Uncharacterised ACR, COG1259 - - - ko:K08999 - - - - ko00000 - - - DNase-RNase,UVR k59_1242123_1 215803.DB30_7493 1.05e-24 102.0 COG0352@1|root,COG0352@2|Bacteria,1RDSU@1224|Proteobacteria,42R5Z@68525|delta/epsilon subdivisions,2WMPN@28221|Deltaproteobacteria,2YVXC@29|Myxococcales 28221|Deltaproteobacteria H Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) thiE - 2.5.1.3 ko:K00788 ko00730,ko01100,map00730,map01100 M00127 R03223,R10712 RC00224,RC03255,RC03397 ko00000,ko00001,ko00002,ko01000 - - - TMP-TENI k59_1242123_2 1122135.KB893167_gene2333 2.59e-53 186.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2TQPG@28211|Alphaproteobacteria 28211|Alphaproteobacteria T COG2204 Response regulator containing CheY-like receiver AAA-type ATPase and DNA-binding domains ntrC - - ko:K07712 ko02020,map02020 M00497 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activ_2,Sigma54_activat k59_449480_1 391603.FBALC1_10497 1.82e-25 99.8 COG0664@1|root,COG0664@2|Bacteria,4NKW5@976|Bacteroidetes,1HYCG@117743|Flavobacteriia 976|Bacteroidetes K - catabolite gene activator and regulatory subunit of cAMP-dependent protein - - - ko:K10914 ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111 - - - ko00000,ko00001,ko03000 - - - HTH_Crp_2,cNMP_binding k59_449480_2 313606.M23134_04455 3.76e-43 155.0 COG1048@1|root,COG1048@2|Bacteria,4NDZT@976|Bacteroidetes,47KF9@768503|Cytophagia 976|Bacteroidetes C aconitate hydratase acnA - 4.2.1.3 ko:K01681 ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00173,M00740 R01324,R01325,R01900 RC00497,RC00498,RC00618 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase,Aconitase_C k59_1352856_2 555793.WSK_0795 1.2e-36 134.0 COG0500@1|root,COG2226@2|Bacteria,1R41W@1224|Proteobacteria,2U1RV@28211|Alphaproteobacteria,2K4TJ@204457|Sphingomonadales 204457|Sphingomonadales Q Methyltransferase domain - - - - - - - - - - - - Methyltransf_25 k59_1127607_1 1229909.NSED_00270 1.13e-154 437.0 COG1378@1|root,arCOG02038@2157|Archaea,41SFR@651137|Thaumarchaeota 651137|Thaumarchaeota K Archaeal transcriptional regulator TrmB - - - - - - - - - - - - Regulator_TrmB,TrmB k59_1127607_2 436308.Nmar_0113 1.68e-27 103.0 COG1321@1|root,arCOG02100@2157|Archaea,41SIJ@651137|Thaumarchaeota 651137|Thaumarchaeota K Helix-turn-helix diphteria tox regulatory element - - - ko:K03709 - - - - ko00000,ko03000 - - - Fe_dep_repr_C,Fe_dep_repress k59_787093_1 1134474.O59_004162 2.23e-62 218.0 COG1629@1|root,COG1629@2|Bacteria,COG4771@2|Bacteria,1MV8W@1224|Proteobacteria,1RMQA@1236|Gammaproteobacteria,1FH60@10|Cellvibrio 1236|Gammaproteobacteria P TonB dependent receptor - - - - - - - - - - - - Plug,TonB_dep_Rec k59_1805121_1 1229909.NSED_04615 4.68e-92 273.0 COG1591@1|root,arCOG00919@2157|Archaea,41SQP@651137|Thaumarchaeota 651137|Thaumarchaeota L A structure-specific endonuclease that resolves Holliday junction (HJ) intermediates during genetic recombination. Cleaves 4-way DNA junctions introducing paired nicks in opposing strands, leaving a 5'-terminal phosphate and a 3'-terminal hydroxyl group that are ligated to produce recombinant products - - - - - - - - - - - - Hjc k59_563189_1 983544.Lacal_0700 1.05e-36 138.0 COG1033@1|root,COG1033@2|Bacteria,4NE0M@976|Bacteroidetes,1HYND@117743|Flavobacteriia 976|Bacteroidetes S of the RND superfamily - - - ko:K07003 - - - - ko00000 - - - MMPL k59_563189_2 1121912.AUHD01000002_gene3267 1.97e-37 137.0 COG4775@1|root,COG4775@2|Bacteria,4NFFZ@976|Bacteroidetes,1HXUZ@117743|Flavobacteriia 976|Bacteroidetes M Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane - - - - - - - - - - - - CarbopepD_reg_2 k59_1129947_2 323848.Nmul_A2653 9.5e-60 194.0 COG0196@1|root,COG0196@2|Bacteria,1MV9I@1224|Proteobacteria,2VHIP@28216|Betaproteobacteria,371XT@32003|Nitrosomonadales 28216|Betaproteobacteria H Belongs to the ribF family ribF - 2.7.1.26,2.7.7.2 ko:K11753 ko00740,ko01100,ko01110,map00740,map01100,map01110 M00125 R00161,R00549 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - FAD_syn,Flavokinase k59_1468870_1 1121333.JMLH01000083_gene2248 8.99e-31 126.0 COG0515@1|root,COG0515@2|Bacteria,1TP3F@1239|Firmicutes,3VP78@526524|Erysipelotrichia 526524|Erysipelotrichia KLT Psort location CytoplasmicMembrane, score prkC - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - PASTA,Pkinase k59_1299100_1 485913.Krac_9291 3.68e-48 171.0 COG3464@1|root,COG3464@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - UPF0236 k59_960113_2 1297617.JPJD01000012_gene814 4.35e-24 102.0 COG1024@1|root,COG1024@2|Bacteria,1TQ89@1239|Firmicutes,247RK@186801|Clostridia,267WS@186813|unclassified Clostridiales 186801|Clostridia I Enoyl-CoA hydratase/isomerase - - 4.2.1.17 ko:K01692,ko:K01715 ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01200,map01212 M00032,M00087 R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093 RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 - - - ECH_1 k59_1805145_1 1122225.AULQ01000003_gene848 1.27e-20 85.5 COG2146@1|root,COG2146@2|Bacteria,4NP7U@976|Bacteroidetes,1I3AW@117743|Flavobacteriia 976|Bacteroidetes P nitrite reductase [NAD(P)H] activity - - - - - - - - - - - - - k59_1805145_2 1121912.AUHD01000002_gene3231 5.2e-37 138.0 COG1629@1|root,COG1629@2|Bacteria,COG4771@2|Bacteria,4NEHN@976|Bacteroidetes,1IJ7E@117743|Flavobacteriia 976|Bacteroidetes P TonB-dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - CarbopepD_reg_2,Plug,TonB_dep_Rec k59_1805151_1 1341646.CBMO010000066_gene1445 6.75e-110 325.0 COG1028@1|root,COG1028@2|Bacteria,2GKI2@201174|Actinobacteria,235H3@1762|Mycobacteriaceae 201174|Actinobacteria IQ COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - - - - - - - - - - - adh_short,adh_short_C2 k59_1468910_1 1280954.HPO_05537 1.27e-74 238.0 COG0591@1|root,COG0591@2|Bacteria,1MUBI@1224|Proteobacteria,2UG5N@28211|Alphaproteobacteria,440PY@69657|Hyphomonadaceae 28211|Alphaproteobacteria E Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family - - - ko:K03307 - - - - ko00000 2.A.21 - - SSF k59_1299141_1 1122137.AQXF01000002_gene350 3.23e-12 66.6 COG4783@1|root,COG4783@2|Bacteria,1MVFV@1224|Proteobacteria,2TTV2@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Peptidase M48 MA20_29180 - - - - - - - - - - - Peptidase_M48,TPR_16,TPR_19 k59_1299141_2 1238182.C882_0486 2.93e-22 95.1 COG1651@1|root,COG1651@2|Bacteria,1MY3H@1224|Proteobacteria,2TTXR@28211|Alphaproteobacteria,2JS48@204441|Rhodospirillales 204441|Rhodospirillales O Thioredoxin - - - - - - - - - - - - DSBA,Thioredoxin_4 k59_507189_1 414684.RC1_0795 2.05e-43 159.0 COG1766@1|root,COG1766@2|Bacteria,1MUQR@1224|Proteobacteria,2TR6J@28211|Alphaproteobacteria,2JQ4P@204441|Rhodospirillales 204441|Rhodospirillales N The M ring may be actively involved in energy transduction fliF - - ko:K02409 ko02040,map02040 - - - ko00000,ko00001,ko02035,ko02044 3.A.6.2,3.A.6.3 - - YscJ_FliF,YscJ_FliF_C k59_960199_1 1479237.JMLY01000001_gene827 7.65e-33 132.0 COG0697@1|root,COG2199@1|root,COG0697@2|Bacteria,COG3706@2|Bacteria,1NECV@1224|Proteobacteria,1S1ZR@1236|Gammaproteobacteria,46766@72275|Alteromonadaceae 1236|Gammaproteobacteria T COG2199 FOG GGDEF domain - - - - - - - - - - - - CHASE3,GAF_2,GGDEF k59_960199_2 1223544.GSI01S_03_01230 2.03e-20 92.0 COG2047@1|root,COG2047@2|Bacteria,2I2H9@201174|Actinobacteria,4GBAX@85026|Gordoniaceae 201174|Actinobacteria S PAC2 family - - - - - - - - - - - - PAC2 k59_960205_1 1122137.AQXF01000006_gene721 3.15e-86 256.0 COG0745@1|root,COG0745@2|Bacteria,1QYPQ@1224|Proteobacteria,2TXUW@28211|Alphaproteobacteria 28211|Alphaproteobacteria T Response regulator receiver cheYIII - - - - - - - - - - - Response_reg k59_960205_2 1122137.AQXF01000006_gene722 1.39e-116 334.0 COG0745@1|root,COG0745@2|Bacteria,1QYPQ@1224|Proteobacteria,2TXUW@28211|Alphaproteobacteria 28211|Alphaproteobacteria T Response regulator receiver - - - - - - - - - - - - Response_reg k59_960208_1 314287.GB2207_01172 2.13e-104 326.0 COG4775@1|root,COG4775@2|Bacteria,1MU0D@1224|Proteobacteria,1RMAP@1236|Gammaproteobacteria,1J4CD@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane bamA GO:0005575,GO:0005623,GO:0008104,GO:0008150,GO:0009279,GO:0009987,GO:0016020,GO:0016043,GO:0019867,GO:0022607,GO:0030312,GO:0030313,GO:0031224,GO:0031230,GO:0031241,GO:0031246,GO:0031975,GO:0032991,GO:0033036,GO:0034613,GO:0043163,GO:0043165,GO:0044085,GO:0044091,GO:0044425,GO:0044462,GO:0044464,GO:0045184,GO:0045229,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0061024,GO:0070727,GO:0071709,GO:0071840,GO:0071944,GO:0072657,GO:0090150,GO:0098552,GO:0098796,GO:1990063 - ko:K07277 - - - - ko00000,ko02000,ko03029 1.B.33 - - Bac_surface_Ag,POTRA k59_789343_1 1137281.D778_00911 7.26e-65 206.0 COG0737@1|root,COG0737@2|Bacteria,4NESM@976|Bacteroidetes,1HZAE@117743|Flavobacteriia 976|Bacteroidetes F Belongs to the 5'-nucleotidase family - - 3.1.3.5 ko:K01081 ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110 - R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346 RC00017 ko00000,ko00001,ko01000 - - - Metallophos k59_789343_2 1121007.AUML01000047_gene4046 1.88e-50 162.0 2C87P@1|root,32H7J@2|Bacteria,4NS7S@976|Bacteroidetes,1I3A8@117743|Flavobacteriia,2YJKN@290174|Aquimarina 976|Bacteroidetes S DoxX-like family - - - - - - - - - - - - DoxX_2 k59_1299215_1 199310.c4176 3.21e-122 362.0 COG1866@1|root,COG1866@2|Bacteria,1MWXN@1224|Proteobacteria,1RPM0@1236|Gammaproteobacteria,3XMXQ@561|Escherichia 1236|Gammaproteobacteria F Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA pckA GO:0000287,GO:0003674,GO:0003824,GO:0004611,GO:0004612,GO:0005488,GO:0005509,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006094,GO:0008150,GO:0008152,GO:0009058,GO:0016051,GO:0016829,GO:0016830,GO:0016831,GO:0019318,GO:0019319,GO:0043167,GO:0043169,GO:0044238,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046364,GO:0046872,GO:0071704,GO:1901576 4.1.1.49 ko:K01610 ko00010,ko00020,ko00620,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00710,map01100,map01110,map01120,map01130,map01200 M00003,M00170 R00341 RC00002,RC02741 ko00000,ko00001,ko00002,ko01000 - - iSF_1195.SF3422,iUTI89_1310.UTI89_C3903 PEPCK_ATP k59_677986_1 1122137.AQXF01000006_gene859 4.68e-84 259.0 COG0795@1|root,COG0795@2|Bacteria,1MVW3@1224|Proteobacteria,2TR76@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Permease, YjgP YjgQ family - - - ko:K11720 ko02010,map02010 M00320 - - ko00000,ko00001,ko00002,ko02000 1.B.42.1 - - YjgP_YjgQ k59_451846_2 1123073.KB899242_gene926 9.11e-14 72.0 COG3320@1|root,COG4221@1|root,COG3320@2|Bacteria,COG4221@2|Bacteria,1QSHC@1224|Proteobacteria,1RQP8@1236|Gammaproteobacteria,1X3FH@135614|Xanthomonadales 135614|Xanthomonadales Q Male sterility protein - - - - - - - - - - - - NAD_binding_4,adh_short k59_451858_2 398527.Bphyt_6658 3.55e-126 371.0 COG0517@1|root,COG0517@2|Bacteria,1MXI6@1224|Proteobacteria,2VJ2W@28216|Betaproteobacteria,1K2WR@119060|Burkholderiaceae 28216|Betaproteobacteria S transposase - - - - - - - - - - - - Y2_Tnp,Zn_Tnp_IS91 k59_789386_1 1122137.AQXF01000003_gene2476 5.08e-66 203.0 COG0735@1|root,COG0735@2|Bacteria,1MZIW@1224|Proteobacteria,2U9G4@28211|Alphaproteobacteria 28211|Alphaproteobacteria P Belongs to the Fur family - - - ko:K09823 ko02024,map02024 - - - ko00000,ko00001,ko03000 - - - FUR k59_563394_1 1207063.P24_04325 2.45e-170 489.0 COG0659@1|root,COG0659@2|Bacteria,1MVWV@1224|Proteobacteria,2TUH6@28211|Alphaproteobacteria,2JQTZ@204441|Rhodospirillales 204441|Rhodospirillales P COG0659 Sulfate permease and related transporters (MFS superfamily) - - - ko:K03321 - - - - ko00000,ko02000 2.A.53.3 - - STAS,Sulfate_transp k59_507317_1 278957.ABEA03000117_gene1116 1.17e-53 178.0 COG0111@1|root,COG0111@2|Bacteria 2|Bacteria EH 4-phosphoerythronate dehydrogenase activity - - 1.1.1.399,1.1.1.95 ko:K00058 ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230 M00020 R01513 RC00031 ko00000,ko00001,ko00002,ko01000,ko04147 - - - 2-Hacid_dh,2-Hacid_dh_C k59_1805278_1 1423816.BACQ01000031_gene1318 3.63e-21 97.8 COG0765@1|root,COG0834@1|root,COG0765@2|Bacteria,COG0834@2|Bacteria,1TPM3@1239|Firmicutes,4HAS2@91061|Bacilli,3F48Y@33958|Lactobacillaceae 91061|Bacilli P ABC transporter permease arpJ - - ko:K02029,ko:K02030 - M00236 - - ko00000,ko00002,ko02000 3.A.1.3 - iSB619.SA_RS09465 BPD_transp_1,SBP_bac_3 k59_1805278_2 247634.GPB2148_2591 3.12e-38 139.0 COG3764@1|root,COG3764@2|Bacteria,1N05G@1224|Proteobacteria,1SB22@1236|Gammaproteobacteria 1236|Gammaproteobacteria M COG3764 Sortase (surface protein transpeptidase) - - - - - - - - - - - - Sortase k59_1589276_1 1078020.KEK_15248 1e-71 219.0 COG3871@1|root,COG3871@2|Bacteria,2IFC3@201174|Actinobacteria,238T2@1762|Mycobacteriaceae 201174|Actinobacteria S stress protein (general stress protein 26) - - - - - - - - - - - - Putative_PNPOx k59_1758988_1 436308.Nmar_1573 7.35e-23 96.3 COG0519@1|root,arCOG00085@2157|Archaea,41SDI@651137|Thaumarchaeota 651137|Thaumarchaeota F Catalyzes the synthesis of GMP from XMP guaA - 6.3.5.2 ko:K01951 ko00230,ko00983,ko01100,map00230,map00983,map01100 M00050 R01230,R01231,R08244 RC00010,RC00204 ko00000,ko00001,ko00002,ko01000,ko01002 - - - GATase,GMP_synt_C,NAD_synthase k59_1758988_2 436308.Nmar_1572 1.12e-60 191.0 arCOG05463@1|root,arCOG05463@2157|Archaea,41SR3@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_347267_1 397278.JOJN01000007_gene3329 4.97e-82 263.0 COG2838@1|root,COG2838@2|Bacteria,2GJ1C@201174|Actinobacteria,4DPVX@85009|Propionibacteriales 201174|Actinobacteria C Isocitrate dehydrogenase icd - 1.1.1.42 ko:K00031 ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146 M00009,M00010,M00173,M00740 R00267,R00268,R01899 RC00001,RC00084,RC00114,RC00626,RC02801 br01601,ko00000,ko00001,ko00002,ko01000 - - - IDH k59_64926_1 1280953.HOC_18119 1.14e-77 249.0 COG0493@1|root,COG1143@1|root,COG0493@2|Bacteria,COG1143@2|Bacteria,1MU2H@1224|Proteobacteria,2TQK5@28211|Alphaproteobacteria 28211|Alphaproteobacteria C COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductases MA20_01050 - 1.17.1.10 ko:K15022 ko00680,ko00720,ko01120,ko01200,map00680,map00720,map01120,map01200 M00377 R00134 RC02796 ko00000,ko00001,ko00002,ko01000 - - - Fer4_20,Fer4_7,NADH_4Fe-4S,Pyr_redox_2,Pyr_redox_3 k59_290717_1 1348657.M622_13805 1.38e-09 64.3 COG0438@1|root,COG0438@2|Bacteria,1MU9C@1224|Proteobacteria,2VJVY@28216|Betaproteobacteria,2KY04@206389|Rhodocyclales 206389|Rhodocyclales M Glycosyltransferase Family 4 - - 2.4.1.346 ko:K13668 - - R11703,R11704 - ko00000,ko01000,ko01003 - GT4 - Glyco_transf_4,Glycos_transf_1 k59_459716_1 1328313.DS2_19021 2.99e-111 354.0 COG1429@1|root,COG1429@2|Bacteria,1MU5W@1224|Proteobacteria,1RQED@1236|Gammaproteobacteria,46629@72275|Alteromonadaceae 1236|Gammaproteobacteria H COG1429 Cobalamin biosynthesis protein CobN and related Mg-chelatases cobN - 6.6.1.2 ko:K02230 ko00860,ko01100,map00860,map01100 - R05227 RC02000 ko00000,ko00001,ko01000 - - - CobN-Mg_chel k59_1025430_1 436308.Nmar_1627 3.77e-92 293.0 COG0209@1|root,arCOG03713@1|root,arCOG03713@2157|Archaea,arCOG04276@2157|Archaea,41SAH@651137|Thaumarchaeota 651137|Thaumarchaeota F Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen - - 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - ATP-cone,Ribonuc_red_lgC,Ribonuc_red_lgN k59_911861_2 1229909.NSED_09010 5e-88 264.0 COG1390@1|root,arCOG00869@2157|Archaea,41T4W@651137|Thaumarchaeota 651137|Thaumarchaeota C Produces ATP from ADP in the presence of a proton gradient across the membrane atpE - - ko:K02121 ko00190,ko01100,map00190,map01100 M00159 - - ko00000,ko00001,ko00002 3.A.2.2,3.A.2.3 - - vATP-synt_E k59_685429_2 1415778.JQMM01000001_gene762 1.24e-36 125.0 COG2261@1|root,COG2261@2|Bacteria,1N72W@1224|Proteobacteria,1S8YP@1236|Gammaproteobacteria,1J72G@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Transglycosylase associated protein yeaQ - - - - - - - - - - - Transgly_assoc k59_685430_1 1229909.NSED_02490 1.6e-30 109.0 COG2146@1|root,arCOG02852@2157|Archaea,41T71@651137|Thaumarchaeota 651137|Thaumarchaeota P of nitrite reductase and ring-hydroxylating - - - ko:K05710 ko00360,ko01120,ko01220,map00360,map01120,map01220 M00545 R06782,R06783 RC00098 br01602,ko00000,ko00001,ko00002 - - - Rieske k59_685430_2 436308.Nmar_0497 1.68e-66 213.0 COG0520@1|root,arCOG00065@2157|Archaea,41SCV@651137|Thaumarchaeota 651137|Thaumarchaeota E Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine - - 2.8.1.7,4.4.1.16 ko:K11717 ko00450,ko01100,map00450,map01100 - R03599,R11528 RC00961,RC01789,RC02313 ko00000,ko00001,ko01000 - - - Aminotran_5 k59_855620_1 1144305.PMI02_05424 2.04e-73 226.0 COG2128@1|root,COG2128@2|Bacteria,1MVWP@1224|Proteobacteria,2VGCN@28211|Alphaproteobacteria,2K62F@204457|Sphingomonadales 204457|Sphingomonadales S Carboxymuconolactone decarboxylase family - - - - - - - - - - - - CMD k59_1589294_1 383381.EH30_01930 1.37e-29 114.0 COG0670@1|root,COG0670@2|Bacteria,1MU69@1224|Proteobacteria,2TRSF@28211|Alphaproteobacteria,2K14K@204457|Sphingomonadales 204457|Sphingomonadales S Belongs to the BI1 family - - - ko:K06890 - - - - ko00000 - - - Bax1-I k59_1081156_1 481805.EcolC_1458 1.92e-123 375.0 COG3468@1|root,COG3468@2|Bacteria,1R9A8@1224|Proteobacteria,1RS0C@1236|Gammaproteobacteria,3XQGW@561|Escherichia 1236|Gammaproteobacteria MU Pertactin yejO - - - - - - - - - - - AIDA,Autotransporter,Pertactin k59_1194191_1 1500893.JQNB01000001_gene1119 1.39e-28 120.0 COG3240@1|root,COG5571@1|root,COG3240@2|Bacteria,COG5571@2|Bacteria,1MWDI@1224|Proteobacteria,1S2RQ@1236|Gammaproteobacteria,1X3QI@135614|Xanthomonadales 135614|Xanthomonadales IN esterase estA - - ko:K12686 - - - - ko00000,ko02000,ko02044 1.B.12.8 - - Autotransporter,Lipase_GDSL k59_459731_1 1229909.NSED_00175 8.15e-06 46.6 COG0576@1|root,arCOG04772@2157|Archaea,41SSU@651137|Thaumarchaeota 651137|Thaumarchaeota O Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ - - - ko:K03687 - - - - ko00000,ko03029,ko03110 - - - GrpE k59_459731_2 436308.Nmar_0096 2.02e-216 612.0 COG0443@1|root,arCOG03060@2157|Archaea,41SCM@651137|Thaumarchaeota 651137|Thaumarchaeota O Heat shock 70 kDa protein dnaK - - ko:K04043 ko03018,ko04212,ko05152,map03018,map04212,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 1.A.33.1 - - HSP70 k59_1137546_1 436308.Nmar_1578 2.1e-29 115.0 COG1001@1|root,arCOG00693@2157|Archaea,41SZH@651137|Thaumarchaeota 651137|Thaumarchaeota F Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family ade - 3.5.4.2 ko:K01486 ko00230,ko01100,map00230,map01100 - R01244 RC00477 ko00000,ko00001,ko01000 - - - Adenine_deam_C,Amidohydro_1 k59_1137546_2 1229909.NSED_00610 3.45e-57 177.0 COG1631@1|root,arCOG04109@2157|Archaea,41SQZ@651137|Thaumarchaeota 651137|Thaumarchaeota J Binds to the 23S rRNA rpl44e - - ko:K02929 ko03010,map03010 M00177,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L44 k59_1137546_3 1229909.NSED_00605 7.46e-35 119.0 COG2051@1|root,arCOG04108@2157|Archaea,41SUD@651137|Thaumarchaeota 651137|Thaumarchaeota J ribosomal protein rps27e - - ko:K02978 ko03010,map03010 M00177,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S27e k59_1194194_1 1229909.NSED_06130 2.43e-243 682.0 COG1028@1|root,arCOG01259@2157|Archaea,41S7V@651137|Thaumarchaeota 651137|Thaumarchaeota I Enoyl-(Acyl carrier protein) reductase - - - - - - - - - - - - adh_short k59_1194194_2 1229909.NSED_06135 1.04e-78 236.0 arCOG10570@1|root,arCOG10570@2157|Archaea,41T75@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_855641_1 987059.RBXJA2T_03561 3.05e-37 150.0 COG1629@1|root,COG1629@2|Bacteria,COG4771@2|Bacteria,1MUWN@1224|Proteobacteria,2VUCY@28216|Betaproteobacteria 28216|Betaproteobacteria P Outer membrane protein beta-barrel family - - - - - - - - - - - - Plug,TonB_dep_Rec k59_572482_1 35754.JNYJ01000017_gene6280 6.06e-82 252.0 COG0566@1|root,COG0566@2|Bacteria,2GP9S@201174|Actinobacteria,4DIFT@85008|Micromonosporales 201174|Actinobacteria J SpoU rRNA Methylase family - - - ko:K03437 - - - - ko00000,ko03016 - - - SpoU_methylase k59_1081173_2 1121875.KB907546_gene2674 1.5e-40 145.0 COG0437@1|root,COG0437@2|Bacteria,4NI8R@976|Bacteroidetes,1I01K@117743|Flavobacteriia 976|Bacteroidetes C 4Fe-4S dicluster domain - - - ko:K00184 - - - - ko00000 5.A.3 - - Fer4_11 k59_1364784_1 1388763.O165_014915 1.77e-65 225.0 COG4783@1|root,COG4783@2|Bacteria,1QTUQ@1224|Proteobacteria,1T1HY@1236|Gammaproteobacteria,1YXYE@136845|Pseudomonas putida group 1236|Gammaproteobacteria S Oxygen tolerance batD - - - - - - - - - - - BatD k59_1138336_2 330214.NIDE1018 3.81e-75 239.0 COG1530@1|root,COG1530@2|Bacteria,3J0DK@40117|Nitrospirae 40117|Nitrospirae J Ribonuclease E/G family - - - ko:K08301 - - - - ko00000,ko01000,ko03009,ko03019 - - - RNase_E_G k59_9101_1 1158345.JNLL01000001_gene1787 9.26e-64 206.0 COG0216@1|root,COG0216@2|Bacteria,2G3PA@200783|Aquificae 200783|Aquificae J Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA prfA - - ko:K02835 - - - - ko00000,ko03012 - - - PCRF,RF-1 k59_1759866_1 216596.RL0160 7.73e-34 134.0 COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,2TRJF@28211|Alphaproteobacteria,4B86G@82115|Rhizobiaceae 28211|Alphaproteobacteria L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity polA GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008408,GO:0008409,GO:0009058,GO:0009059,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901362,GO:1901363,GO:1901576 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1 k59_968785_1 595460.RRSWK_05276 1.61e-32 129.0 COG0584@1|root,COG0584@2|Bacteria,2J0S0@203682|Planctomycetes 203682|Planctomycetes C Glycerophosphoryl diester phosphodiesterase family - - 3.1.4.46 ko:K01126 ko00564,map00564 - R01030,R01470 RC00017,RC00425 ko00000,ko00001,ko01000 - - - GDPD,GPDPase_memb,HEAT_2 k59_516739_1 68223.JNZY01000005_gene3990 1.54e-45 160.0 COG0477@1|root,COG2814@2|Bacteria,2I4XI@201174|Actinobacteria 201174|Actinobacteria EGP Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 k59_1082105_1 240292.Ava_4484 3.46e-66 223.0 COG0339@1|root,COG0339@2|Bacteria,1G05V@1117|Cyanobacteria,1HJC4@1161|Nostocales 1117|Cyanobacteria E PFAM Peptidase family M3 prlC - 3.4.24.70 ko:K01414 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M3 k59_1138352_1 289376.THEYE_A1448 3.31e-87 267.0 COG0050@1|root,COG0050@2|Bacteria,3J0DG@40117|Nitrospirae 40117|Nitrospirae J This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis - - - ko:K02358 - - - - ko00000,ko03012,ko03029,ko04147 - - - GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3 k59_968790_1 591158.SSMG_08048 2.72e-11 66.6 COG2378@1|root,COG2378@2|Bacteria,2GIZC@201174|Actinobacteria 201174|Actinobacteria K transcriptional regulator - - - - - - - - - - - - HTH_11,WYL k59_968790_3 1159870.KB907784_gene731 6e-40 145.0 COG3039@1|root,COG3039@2|Bacteria,1MVDK@1224|Proteobacteria,2VI1H@28216|Betaproteobacteria 28216|Betaproteobacteria L PFAM transposase, IS4 family protein - - - ko:K07481 - - - - ko00000 - - - DDE_Tnp_1,DUF772 k59_1759874_2 396588.Tgr7_2959 4.14e-28 111.0 COG1561@1|root,COG1561@2|Bacteria,1MWRA@1224|Proteobacteria,1RMAB@1236|Gammaproteobacteria,1WX83@135613|Chromatiales 135613|Chromatiales S PFAM YicC-like - - - - - - - - - - - - DUF1732,YicC_N k59_686406_1 880072.Desac_0849 3.26e-28 112.0 COG1847@1|root,COG1847@2|Bacteria,1RB1P@1224|Proteobacteria,42QPK@68525|delta/epsilon subdivisions,2WN58@28221|Deltaproteobacteria,2MRTE@213462|Syntrophobacterales 28221|Deltaproteobacteria S Jag_N - - - ko:K06346 - - - - ko00000 - - - Jag_N,KH_4,R3H k59_1308167_1 1123035.ARLA01000028_gene2530 4.29e-06 53.9 COG3188@1|root,COG3188@2|Bacteria,4NHVA@976|Bacteroidetes,1I7AS@117743|Flavobacteriia 976|Bacteroidetes NU usher protein - - - - - - - - - - - - - k59_348124_1 67352.JODS01000039_gene6747 1.21e-72 239.0 COG1387@1|root,COG1796@1|root,COG1387@2|Bacteria,COG1796@2|Bacteria,2GMFH@201174|Actinobacteria 201174|Actinobacteria E PHP domain - - - ko:K02347 - - - - ko00000,ko03400 - - - DNA_pol_B_thumb,HHH_5,HHH_8,PHP k59_9109_1 1122137.AQXF01000004_gene1646 4.84e-47 164.0 COG5338@1|root,COG5338@2|Bacteria,1PFWT@1224|Proteobacteria,2U090@28211|Alphaproteobacteria 28211|Alphaproteobacteria M Protein conserved in bacteria - - - - - - - - - - - - BBP2_2 k59_9109_2 745310.G432_03275 3.27e-38 140.0 COG0639@1|root,COG0639@2|Bacteria,1RD8M@1224|Proteobacteria,2U7N2@28211|Alphaproteobacteria,2K1WW@204457|Sphingomonadales 204457|Sphingomonadales T COG0639 Diadenosine tetraphosphatase and related serine threonine protein phosphatases - - 3.1.3.16 ko:K07313 - - - - ko00000,ko01000 - - - Metallophos k59_912715_2 589924.Ferp_2485 2.89e-05 47.0 COG0065@1|root,arCOG01698@2157|Archaea,2XTWH@28890|Euryarchaeota,245PP@183980|Archaeoglobi 183980|Archaeoglobi E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate - - 4.2.1.33,4.2.1.35 ko:K01703 ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230 M00432,M00535 R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170 RC00497,RC00976,RC00977,RC01041,RC01046,RC03072 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase k59_1194936_1 436308.Nmar_0066 3.55e-32 121.0 COG1467@1|root,arCOG04110@2157|Archaea,41SCB@651137|Thaumarchaeota 651137|Thaumarchaeota L Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair priS - - ko:K02683 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - DNA_primase_S k59_404018_1 342113.DM82_1006 7.46e-60 206.0 COG0072@1|root,COG0073@1|root,COG0072@2|Bacteria,COG0073@2|Bacteria,1MWKS@1224|Proteobacteria,2VHR1@28216|Betaproteobacteria,1K1SA@119060|Burkholderiaceae 28216|Betaproteobacteria J Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily pheT - 6.1.1.20 ko:K01890 ko00970,map00970 M00359,M00360 R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - B3_4,B5,FDX-ACB,tRNA_bind k59_1308177_1 436308.Nmar_0310 1.04e-144 412.0 COG0179@1|root,arCOG00235@2157|Archaea,41S5K@651137|Thaumarchaeota 651137|Thaumarchaeota Q 2-keto-4-pentenoate hydratase 2-oxohepta-3-ene-1,7-dioic acid hydratase - - - - - - - - - - - - FAA_hydrolase k59_629990_1 1545915.JROG01000004_gene2190 3.64e-75 236.0 COG1228@1|root,COG1228@2|Bacteria,1MVAF@1224|Proteobacteria,2TSAB@28211|Alphaproteobacteria,2K2NQ@204457|Sphingomonadales 204457|Sphingomonadales Q Amidohydrolase family - - - - - - - - - - - - Amidohydro_1 k59_1478027_1 391603.FBALC1_04252 2.15e-61 196.0 COG0284@1|root,COG0284@2|Bacteria,4NE12@976|Bacteroidetes,1HX31@117743|Flavobacteriia 976|Bacteroidetes F Belongs to the OMP decarboxylase family. Type 2 subfamily pyrF GO:0003674,GO:0003824,GO:0004590,GO:0006139,GO:0006206,GO:0006207,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019856,GO:0034641,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046112,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.1.23 ko:K01591 ko00240,ko01100,map00240,map01100 M00051 R00965 RC00409 ko00000,ko00001,ko00002,ko01000 - - - OMPdecase k59_1478027_2 1380600.AUYN01000009_gene1699 1.28e-22 88.2 2EN44@1|root,33FS7@2|Bacteria,4NY0X@976|Bacteroidetes,1I5NI@117743|Flavobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_1194955_2 158500.BV97_01777 3.96e-133 394.0 COG2303@1|root,COG2303@2|Bacteria,1MU3F@1224|Proteobacteria,2TT3C@28211|Alphaproteobacteria,2K0QC@204457|Sphingomonadales 204457|Sphingomonadales E Oxidoreductase - - 1.1.5.9 ko:K19813 ko00030,ko01100,ko01110,ko01130,map00030,map01100,map01110,map01130 - R00305 RC00066 ko00000,ko00001,ko01000 - - - FAD_binding_2,GMC_oxred_C,GMC_oxred_N,NAD_binding_8 k59_178038_1 1117647.M5M_06505 2.46e-05 51.6 COG1629@1|root,COG4771@2|Bacteria,1MUNK@1224|Proteobacteria,1RN9S@1236|Gammaproteobacteria,1J59B@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P COG1629 Outer membrane receptor proteins, mostly Fe transport - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_65856_1 1247963.JPHU01000005_gene449 6.06e-117 348.0 COG3039@1|root,COG3039@2|Bacteria,1MUVI@1224|Proteobacteria,2TSA7@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Transposase - - - - - - - - - - - - DDE_Tnp_1,DDE_Tnp_1_6,DUF772 k59_9114_2 945713.IALB_1760 7.42e-84 258.0 COG0524@1|root,COG0524@2|Bacteria 2|Bacteria G Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway adoK GO:0000166,GO:0000287,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0004001,GO:0005488,GO:0005524,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0005975,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019200,GO:0019205,GO:0019206,GO:0019438,GO:0019637,GO:0019693,GO:0030554,GO:0032549,GO:0032550,GO:0032552,GO:0032553,GO:0032554,GO:0032555,GO:0032559,GO:0032560,GO:0032561,GO:0032567,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044262,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046033,GO:0046390,GO:0046483,GO:0046835,GO:0046872,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.7.1.15,2.7.1.20 ko:K00852,ko:K00856 ko00030,ko00230,ko01100,map00030,map00230,map01100 - R00185,R01051,R02750 RC00002,RC00017 ko00000,ko00001,ko01000 - - iAF987.Gmet_2683 PfkB k59_516749_1 1254432.SCE1572_01175 1.44e-09 62.8 COG2003@1|root,COG2003@2|Bacteria 2|Bacteria L Belongs to the UPF0758 family radC - - ko:K03630 - - - - ko00000 - - - RadC k59_743215_1 290400.Jann_2637 1.36e-16 85.1 COG0405@1|root,COG0405@2|Bacteria,1MUV6@1224|Proteobacteria,2TR49@28211|Alphaproteobacteria 28211|Alphaproteobacteria E gamma-glutamyltransferase ggt - 2.3.2.2,3.4.19.13 ko:K00681 ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100 - R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935 RC00064,RC00090,RC00096 ko00000,ko00001,ko01000,ko01002 - - - G_glu_transpept k59_1251693_1 1122137.AQXF01000001_gene2936 1.52e-48 163.0 2AFUA@1|root,315WQ@2|Bacteria,1NHGB@1224|Proteobacteria,2TQWW@28211|Alphaproteobacteria 28211|Alphaproteobacteria S transmembrane protein (Alph_Pro_TM) MA20_19830 - - - - - - - - - - - Alph_Pro_TM k59_1308187_1 349102.Rsph17025_2960 1.93e-42 148.0 COG0309@1|root,COG3293@1|root,COG0309@2|Bacteria,COG3293@2|Bacteria,1NNGG@1224|Proteobacteria,2UKBN@28211|Alphaproteobacteria,1FD5E@1060|Rhodobacter 28211|Alphaproteobacteria O PFAM transposase, IS4 family protein - - - - - - - - - - - - DDE_Tnp_1_2 k59_1308187_2 1121022.ABENE_08015 1.31e-50 163.0 COG3293@1|root,COG3293@2|Bacteria,1RDDI@1224|Proteobacteria,2U7E3@28211|Alphaproteobacteria,2KJ0H@204458|Caulobacterales 204458|Caulobacterales L Putative transposase of IS4/5 family (DUF4096) - - - - - - - - - - - - DUF4096 k59_800237_1 1385517.N800_10545 2.55e-55 187.0 COG4191@1|root,COG4191@2|Bacteria,1MWR3@1224|Proteobacteria,1RMH4@1236|Gammaproteobacteria,1X43M@135614|Xanthomonadales 135614|Xanthomonadales T Histidine kinase regS - 2.7.13.3 ko:K15011 ko02020,map02020 M00523 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA k59_234412_1 1286106.MPL1_09200 8.85e-44 156.0 COG1611@1|root,COG1611@2|Bacteria,1MVQJ@1224|Proteobacteria,1RQHX@1236|Gammaproteobacteria,4606N@72273|Thiotrichales 72273|Thiotrichales S Domain of unknown function (DUF4478) - - 3.2.2.10 ko:K06966 ko00230,ko00240,map00230,map00240 - R00182,R00510 RC00063,RC00318 ko00000,ko00001,ko01000 - - - DUF3412,DUF4478,Lysine_decarbox k59_291741_1 419947.MRA_1846 1.58e-35 137.0 COG2936@1|root,COG2936@2|Bacteria,2GK8B@201174|Actinobacteria,235H0@1762|Mycobacteriaceae 201174|Actinobacteria S peptidase S15 - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K06978 - - - - ko00000 - - - PepX_C,Peptidase_S15 k59_800250_1 1318628.MARLIPOL_04530 2.92e-49 178.0 COG0810@1|root,COG0810@2|Bacteria 2|Bacteria M energy transducer activity - - - ko:K02283 - - - - ko00000,ko02035,ko02044 - - - DUF4488,TonB_C k59_1478051_1 395964.KE386496_gene1656 9.26e-48 169.0 COG3914@1|root,COG3914@2|Bacteria,1QU3U@1224|Proteobacteria,2TVYA@28211|Alphaproteobacteria,3N9KD@45404|Beijerinckiaceae 28211|Alphaproteobacteria O Glycosyl transferase family 41 - - - - - - - - - - - - Glyco_transf_41 k59_856566_1 436308.Nmar_1388 8.53e-127 375.0 COG1032@1|root,arCOG01357@2157|Archaea,41SCX@651137|Thaumarchaeota 651137|Thaumarchaeota C Radical SAM - - - - - - - - - - - - Radical_SAM k59_1647351_1 525897.Dbac_1945 4.76e-29 121.0 COG0471@1|root,COG0490@1|root,COG0471@2|Bacteria,COG0490@2|Bacteria,1MU0K@1224|Proteobacteria,42MR7@68525|delta/epsilon subdivisions,2WIKA@28221|Deltaproteobacteria,2M9JU@213115|Desulfovibrionales 28221|Deltaproteobacteria P PFAM Citrate transporter - - - - - - - - - - - - CitMHS,Na_sulph_symp,TrkA_C k59_800258_1 28444.JODQ01000006_gene355 2.15e-20 92.4 COG4191@1|root,COG4191@2|Bacteria,2I3H5@201174|Actinobacteria,4EM2V@85012|Streptosporangiales 201174|Actinobacteria T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HAMP,HATPase_c,HisKA k59_800258_2 446466.Cfla_3657 4.95e-23 91.3 COG0640@1|root,COG0640@2|Bacteria,2IQDH@201174|Actinobacteria,4F1FW@85016|Cellulomonadaceae 201174|Actinobacteria K helix_turn_helix, Arsenical Resistance Operon Repressor - - - ko:K03892 - - - - ko00000,ko03000 - - - HTH_5 k59_348167_1 589865.DaAHT2_1753 7.65e-44 160.0 COG0367@1|root,COG0367@2|Bacteria,1MW4E@1224|Proteobacteria,42MEI@68525|delta/epsilon subdivisions,2WJEG@28221|Deltaproteobacteria,2MN6X@213118|Desulfobacterales 28221|Deltaproteobacteria E Asparagine synthase asnB - 6.3.5.4 ko:K01953 ko00250,ko01100,ko01110,map00250,map01100,map01110 - R00578 RC00010 ko00000,ko00001,ko01000,ko01002 - - - Asn_synthase,GATase_7 k59_1026308_1 1131814.JAFO01000001_gene2837 7.97e-26 97.8 2BKDJ@1|root,32EU8@2|Bacteria,1RKF1@1224|Proteobacteria,2UBM3@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_1026308_2 78245.Xaut_0146 1e-59 204.0 COG0778@1|root,COG0778@2|Bacteria,1Q0G9@1224|Proteobacteria,2U1WC@28211|Alphaproteobacteria,3F0T2@335928|Xanthobacteraceae 28211|Alphaproteobacteria C Nitroreductase family - - - - - - - - - - - - Nitroreductase,Rhodanese k59_65898_1 511145.b4170 3.02e-125 373.0 COG0323@1|root,COG0323@2|Bacteria,1MV61@1224|Proteobacteria,1RM89@1236|Gammaproteobacteria,3XN0H@561|Escherichia 1236|Gammaproteobacteria L This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of mutL GO:0000018,GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008144,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019219,GO:0019222,GO:0030554,GO:0031323,GO:0032300,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033554,GO:0034641,GO:0035639,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051171,GO:0051716,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901363,GO:1990391 - ko:K03572 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - DNA_mis_repair,HATPase_c_3,MutL_C k59_291763_1 421052.F945_02003 2.06e-15 74.7 COG0372@1|root,COG0372@2|Bacteria,1MUKX@1224|Proteobacteria,1RNT1@1236|Gammaproteobacteria,3NKGX@468|Moraxellaceae 1236|Gammaproteobacteria C Belongs to the citrate synthase family prpC GO:0003674,GO:0003824,GO:0004108,GO:0006082,GO:0006091,GO:0006113,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0009987,GO:0015980,GO:0016740,GO:0016746,GO:0016829,GO:0016830,GO:0016833,GO:0016999,GO:0017144,GO:0019541,GO:0019679,GO:0019752,GO:0032787,GO:0036440,GO:0043436,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0046459,GO:0046912,GO:0050440,GO:0055114,GO:0071704 2.3.3.5 ko:K01659 ko00640,map00640 - R00931 RC00004,RC00406,RC02827 ko00000,ko00001,ko01000 - - iECED1_1282.ECED1_0365,iECIAI1_1343.ECIAI1_0334,iECIAI39_1322.ECIAI39_0347,iECP_1309.ECP_0408,iECSF_1327.ECSF_0308,iEcE24377_1341.EcE24377A_0357,iJN746.PP_2335,iLF82_1304.LF82_1740,iNRG857_1313.NRG857_01630 Citrate_synt k59_291763_2 1265313.HRUBRA_02537 4.81e-99 298.0 COG0627@1|root,COG0627@2|Bacteria,1MUID@1224|Proteobacteria,1RMR3@1236|Gammaproteobacteria,1J4UA@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Serine hydrolase involved in the detoxification of formaldehyde fghA - 3.1.2.12 ko:K01070 ko00680,ko01120,ko01200,map00680,map01120,map01200 - R00527 RC00167,RC00320 ko00000,ko00001,ko01000 - CE1 - Esterase k59_1534210_1 1229909.NSED_09785 1.45e-05 50.1 arCOG10512@1|root,arCOG10512@2157|Archaea,41T3J@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1478068_1 565045.NOR51B_2248 1.47e-177 511.0 COG3746@1|root,COG3746@2|Bacteria,1RAJS@1224|Proteobacteria,1S3ID@1236|Gammaproteobacteria 1236|Gammaproteobacteria P Phosphate-selective porin O and P - - - - - - - - - - - - Porin_O_P k59_234442_1 83332.Rv1350 2.48e-25 105.0 COG1028@1|root,COG1028@2|Bacteria,2GIX2@201174|Actinobacteria,23414@1762|Mycobacteriaceae 201174|Actinobacteria IQ reductase fabG_1 GO:0008150,GO:0040007 1.1.1.100 ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 k59_1759923_2 715451.ambt_19690 9.46e-45 160.0 COG3590@1|root,COG3590@2|Bacteria,1MVNQ@1224|Proteobacteria,1RNNA@1236|Gammaproteobacteria,464DA@72275|Alteromonadaceae 1236|Gammaproteobacteria O Peptidase, M13 pepO - 3.4.24.71 ko:K01415,ko:K07386 - - - - ko00000,ko01000,ko01002,ko04147 - - - Peptidase_M13,Peptidase_M13_N k59_1478077_1 118166.JH976538_gene5065 1.31e-43 161.0 COG2202@1|root,COG2203@1|root,COG4585@1|root,COG2202@2|Bacteria,COG2203@2|Bacteria,COG4585@2|Bacteria 2|Bacteria T Histidine kinase - - 2.7.13.3 ko:K07683 ko02020,map02020 M00483 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - GAF_2,HATPase_c,HisKA_3,PAS_3,PAS_4,PAS_9,Response_reg k59_1592989_1 740709.A10D4_11781 4.58e-14 72.8 COG2304@1|root,COG2304@2|Bacteria,1QXYA@1224|Proteobacteria,1T3K9@1236|Gammaproteobacteria,2QFMJ@267893|Idiomarinaceae 1236|Gammaproteobacteria S von Willebrand factor (vWF) type A domain - - - - - - - - - - - - VWA_2 k59_406758_2 404589.Anae109_1964 4.91e-10 63.2 COG1166@1|root,COG1166@2|Bacteria,1MU80@1224|Proteobacteria,42M2B@68525|delta/epsilon subdivisions,2WJDZ@28221|Deltaproteobacteria,2YTWQ@29|Myxococcales 28221|Deltaproteobacteria H Catalyzes the biosynthesis of agmatine from arginine speA - 4.1.1.19 ko:K01585 ko00330,ko01100,map00330,map01100 M00133 R00566 RC00299 ko00000,ko00001,ko00002,ko01000 - - - Orn_Arg_deC_N k59_1592996_2 1429851.X548_18860 7.24e-11 66.2 COG4969@1|root,COG4969@2|Bacteria,1NDVH@1224|Proteobacteria,1T4AE@1236|Gammaproteobacteria 1236|Gammaproteobacteria NU Protein of unknown function (DUF2628) - - - - - - - - - - - - DUF2628 k59_1141021_1 436308.Nmar_1795 3.2e-113 329.0 COG1646@1|root,arCOG01085@2157|Archaea,41SH4@651137|Thaumarchaeota 651137|Thaumarchaeota H Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids - - 2.5.1.41 ko:K17104 ko00564,map00564 - R04158 RC01091 ko00000,ko00001,ko01000 - - - PcrB k59_1141021_2 436308.Nmar_1794 1.06e-93 301.0 COG1933@1|root,arCOG04447@2157|Archaea,41SYW@651137|Thaumarchaeota 651137|Thaumarchaeota L Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase polC - 2.7.7.7 ko:K02322 ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030 M00264 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032 - - - PolC_DP2 k59_1762561_1 1122137.AQXF01000001_gene3006 2.76e-07 55.1 COG3710@1|root,COG3710@2|Bacteria,1N2RT@1224|Proteobacteria 1224|Proteobacteria K Transcriptional regulatory protein, C terminal - - - - - - - - - - - - TPR_16,TPR_2,TPR_8,Trans_reg_C k59_1762561_2 1122137.AQXF01000001_gene3084 2.03e-22 109.0 COG2931@1|root,COG3210@1|root,COG2931@2|Bacteria,COG3210@2|Bacteria,1MU7T@1224|Proteobacteria,2TRVY@28211|Alphaproteobacteria 28211|Alphaproteobacteria Q COG2931 RTX toxins and related Ca2 -binding proteins - - - ko:K07004 - - - - ko00000 - - - Calx-beta,DUF4347,HemolysinCabind,P_proprotein,Peptidase_M10,Peptidase_M10_C,Peptidase_S8 k59_1029159_1 661478.OP10G_0302 1.01e-20 85.1 2DPZQ@1|root,3344M@2|Bacteria 2|Bacteria S Putative zinc ribbon domain - - - - - - - - - - - - Zn_ribbon_2 k59_406773_1 316407.85677096 1.2e-114 339.0 COG2271@1|root,COG2271@2|Bacteria,1MVPS@1224|Proteobacteria,1RPRB@1236|Gammaproteobacteria,3XP6M@561|Escherichia 1236|Gammaproteobacteria P Probably responsible for the transport of L-galactonate from the periplasm across the inner membrane. Is essential for growth on L-galactonate as the sole carbon source yjjL GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008643,GO:0015711,GO:0015718,GO:0015849,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0034219,GO:0034220,GO:0042873,GO:0044425,GO:0044464,GO:0046942,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0098656,GO:1903825,GO:1905039 - - - - - - - - - iEC55989_1330.EC55989_4444,iEcE24377_1341.EcE24377A_4501 MFS_1 k59_1029162_1 1122137.AQXF01000002_gene446 1.45e-88 267.0 COG3186@1|root,COG3186@2|Bacteria,1MU29@1224|Proteobacteria,2TU1E@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Phenylalanine-4-hydroxylase phhA GO:0003674,GO:0003824,GO:0004497,GO:0004505,GO:0006082,GO:0006520,GO:0006558,GO:0006559,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009072,GO:0009074,GO:0009987,GO:0016054,GO:0016491,GO:0016705,GO:0016714,GO:0017144,GO:0019439,GO:0019752,GO:0042737,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0055114,GO:0071704,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606,GO:1902221,GO:1902222 1.14.16.1 ko:K00500 ko00360,ko00400,ko00790,ko01100,ko01230,map00360,map00400,map00790,map01100,map01230 - R01795,R07211 RC00490 ko00000,ko00001,ko01000 - - - Biopterin_H k59_1029162_2 1122137.AQXF01000002_gene444 4.87e-45 151.0 COG4319@1|root,COG4319@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - DUF4440,SnoaL_4 k59_1029162_3 1122137.AQXF01000002_gene442 6.92e-78 243.0 COG0334@1|root,COG0334@2|Bacteria,1MUXS@1224|Proteobacteria,2VGKD@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Belongs to the Glu Leu Phe Val dehydrogenases family - - 1.4.1.9 ko:K00263 ko00280,ko00290,ko01100,ko01110,ko01130,map00280,map00290,map01100,map01110,map01130 - R01088,R01434,R02196 RC00006,RC00036 ko00000,ko00001,ko01000 - - - ELFV_dehydrog,ELFV_dehydrog_N k59_915111_1 1453501.JELR01000002_gene1108 1.06e-39 151.0 COG1404@1|root,COG1404@2|Bacteria,1MVJE@1224|Proteobacteria,1RQ2M@1236|Gammaproteobacteria,4683H@72275|Alteromonadaceae 1236|Gammaproteobacteria O Peptidase inhibitor I9 - - - - - - - - - - - - Inhibitor_I9,PA,Peptidase_S8 k59_1423357_1 675812.VHA_000807 2.57e-29 113.0 COG2857@1|root,COG2857@2|Bacteria,1QFU2@1224|Proteobacteria,1RN4Y@1236|Gammaproteobacteria,1XSUK@135623|Vibrionales 135623|Vibrionales P cytochrome c1 petC - - ko:K00413 ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016 M00151,M00152 - - ko00000,ko00001,ko00002 - - - Cytochrom_C1 k59_1423357_2 314282.PCNPT3_09680 2.31e-09 57.0 COG0625@1|root,COG0625@2|Bacteria,1MXJD@1224|Proteobacteria,1RP12@1236|Gammaproteobacteria,2QHN8@267894|Psychromonadaceae 1236|Gammaproteobacteria O Glutathione S-transferase, N-terminal domain sspA GO:0001000,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0006950,GO:0008150,GO:0009605,GO:0009889,GO:0009891,GO:0009893,GO:0009991,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0019899,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031667,GO:0042594,GO:0043175,GO:0044424,GO:0044444,GO:0044464,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0070063,GO:0080090,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141 - ko:K03599 - - - - ko00000,ko02000,ko03021 1.A.12.3.1 - - GST_C,GST_N,GST_N_3 k59_294321_1 314287.GB2207_03284 5.98e-125 389.0 COG1197@1|root,COG1197@2|Bacteria,1MUXG@1224|Proteobacteria,1RNCU@1236|Gammaproteobacteria,1J4G0@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site mfd GO:0000715,GO:0000716,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006283,GO:0006289,GO:0006355,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008094,GO:0008150,GO:0008152,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0015616,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019219,GO:0019222,GO:0019899,GO:0031323,GO:0031326,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0043175,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0051276,GO:0051716,GO:0060255,GO:0065007,GO:0070063,GO:0071704,GO:0071840,GO:0080090,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1903506,GO:2000112,GO:2001141 - ko:K03723 ko03420,map03420 - - - ko00000,ko00001,ko01000,ko03400 - - - CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF k59_1536827_2 13690.CP98_00602 1.33e-20 88.6 COG2186@1|root,COG2186@2|Bacteria,1NVKQ@1224|Proteobacteria,2USDC@28211|Alphaproteobacteria,2KAER@204457|Sphingomonadales 204457|Sphingomonadales K Transcriptional regulator - - - - - - - - - - - - FCD,GntR k59_12506_1 1244869.H261_13900 5.46e-40 144.0 COG2089@1|root,COG2089@2|Bacteria,1MWG3@1224|Proteobacteria,2TRA6@28211|Alphaproteobacteria,2JRJX@204441|Rhodospirillales 204441|Rhodospirillales M COG2089 Sialic acid synthase - - - - - - - - - - - - NeuB,SAF k59_12506_2 93059.P9211_12511 1.19e-51 173.0 COG0223@1|root,COG0223@2|Bacteria 2|Bacteria J Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus - GO:0003674,GO:0003824,GO:0004479,GO:0005488,GO:0005515,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006413,GO:0006464,GO:0006518,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009405,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016741,GO:0016742,GO:0019538,GO:0019988,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036211,GO:0042802,GO:0042803,GO:0043043,GO:0043170,GO:0043412,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044419,GO:0046483,GO:0046983,GO:0051704,GO:0071704,GO:0071951,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 2.1.2.2,2.1.2.9 ko:K00604,ko:K11175 ko00230,ko00670,ko00970,ko01100,ko01110,ko01130,map00230,map00670,map00970,map01100,map01110,map01130 M00048 R03940,R04325,R04326 RC00026,RC00165,RC00197,RC01128 ko00000,ko00001,ko00002,ko01000 - - - Formyl_trans_N k59_803616_2 436308.Nmar_0778 3.51e-16 73.6 COG0517@1|root,arCOG00606@2157|Archaea,41SRY@651137|Thaumarchaeota 651137|Thaumarchaeota S Domain in cystathionine beta-synthase and other proteins. - - - - - - - - - - - - CBS k59_577090_1 383407.XOC_4606 2.16e-57 193.0 COG1485@1|root,COG1485@2|Bacteria,1MUUW@1224|Proteobacteria,1RMTJ@1236|Gammaproteobacteria,1X4VN@135614|Xanthomonadales 135614|Xanthomonadales D Reduces the stability of FtsZ polymers in the presence of ATP zapE - - ko:K06916 - - - - ko00000,ko03036 - - - AFG1_ATPase k59_1085280_1 278963.ATWD01000002_gene445 2.9e-25 105.0 COG4225@1|root,COG4225@2|Bacteria,3Y3V1@57723|Acidobacteria,2JIHU@204432|Acidobacteriia 204432|Acidobacteriia S Glycosyl Hydrolase Family 88 - - - - - - - - - - - - Glyco_hydro_88 k59_1085280_2 491205.JARQ01000010_gene3686 5.8e-19 84.7 COG2755@1|root,COG2755@2|Bacteria,4NKE5@976|Bacteroidetes,1HXIM@117743|Flavobacteriia,3ZQBS@59732|Chryseobacterium 976|Bacteroidetes E GDSL-like Lipase/Acylhydrolase family - - - - - - - - - - - - Lipase_GDSL_2,Pec_lyase k59_860487_1 1279017.AQYJ01000020_gene1318 8.5e-103 312.0 COG4799@1|root,COG4799@2|Bacteria,1MVAX@1224|Proteobacteria,1RNV5@1236|Gammaproteobacteria,464FJ@72275|Alteromonadaceae 1236|Gammaproteobacteria I Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) liuB - 6.4.1.4 ko:K01969 ko00280,ko01100,map00280,map01100 M00036 R04138 RC00367,RC00942 ko00000,ko00001,ko00002,ko01000 - - - Carboxyl_trans k59_1030058_1 998674.ATTE01000001_gene4399 3.56e-53 177.0 COG1253@1|root,COG1253@2|Bacteria,1MWT3@1224|Proteobacteria,1RQBC@1236|Gammaproteobacteria,46284@72273|Thiotrichales 72273|Thiotrichales S Domain of unknown function DUF21 - - - - - - - - - - - - CBS,DUF21 k59_407747_1 1415778.JQMM01000001_gene1740 5.44e-76 242.0 COG0007@1|root,COG1648@1|root,COG0007@2|Bacteria,COG1648@2|Bacteria,1MUI0@1224|Proteobacteria,1RM9V@1236|Gammaproteobacteria,1J4IM@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme cysG - 1.3.1.76,2.1.1.107,4.99.1.4 ko:K02302,ko:K02303 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R02864,R03194,R03947 RC00003,RC00871,RC01012,RC01034 ko00000,ko00001,ko00002,ko01000 - - iJN746.PP_3999 CysG_dimeriser,NAD_binding_7,Sirohm_synth_M,TP_methylase k59_520172_1 667632.KB890196_gene3451 6.89e-88 288.0 COG0086@1|root,COG0086@2|Bacteria,1MU3M@1224|Proteobacteria,2VIF3@28216|Betaproteobacteria,1K0RX@119060|Burkholderiaceae 28216|Betaproteobacteria K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoC - 2.7.7.6 ko:K03046 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5 k59_1085287_1 222534.KB893705_gene5926 1.69e-24 107.0 COG2909@1|root,COG3899@1|root,COG2909@2|Bacteria,COG3899@2|Bacteria,2GM1B@201174|Actinobacteria,4EWC9@85013|Frankiales 201174|Actinobacteria K AAA ATPase domain - - - - - - - - - - - - AAA_16,GerE k59_1537845_1 1096930.L284_06080 7.2e-140 406.0 COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,2TRN7@28211|Alphaproteobacteria,2K1EA@204457|Sphingomonadales 204457|Sphingomonadales C COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes - - 1.8.1.4 ko:K00382 ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00036,M00307,M00532 R00209,R01221,R01698,R03815,R07618,R08549 RC00004,RC00022,RC00583,RC02742,RC02833,RC02834 br01601,ko00000,ko00001,ko00002,ko01000,ko04147 - - - Pyr_redox_2,Pyr_redox_dim k59_689961_1 305900.GV64_07400 5.68e-54 191.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1XHXU@135619|Oceanospirillales 135619|Oceanospirillales V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_295250_1 1123251.ATWM01000001_gene553 2.51e-13 70.9 COG3091@1|root,COG3091@2|Bacteria,2IJ4Z@201174|Actinobacteria,4FGNV@85021|Intrasporangiaceae 201174|Actinobacteria S SprT homologues. - - - - - - - - - - - - SprT-like k59_1198521_1 1122137.AQXF01000002_gene539 8.95e-11 62.0 COG0046@1|root,COG0046@2|Bacteria,1MYN4@1224|Proteobacteria,2TRGM@28211|Alphaproteobacteria 28211|Alphaproteobacteria F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL purL - 6.3.5.3 ko:K01952 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04463 RC00010,RC01160 ko00000,ko00001,ko00002,ko01000 - - - AIRS,AIRS_C k59_1198521_2 1323663.AROI01000001_gene1014 4.74e-42 153.0 COG2114@1|root,COG2114@2|Bacteria,1R312@1224|Proteobacteria,1SHQJ@1236|Gammaproteobacteria 1236|Gammaproteobacteria T Pfam Adenylate and Guanylate cyclase catalytic domain - - - - - - - - - - - - - k59_125465_1 1229909.NSED_09475 6.54e-189 533.0 COG0531@1|root,arCOG00009@2157|Archaea,41SXX@651137|Thaumarchaeota 651137|Thaumarchaeota E amino acid - - - ko:K03294 - - - - ko00000 2.A.3.2 - - AA_permease_2 k59_1255064_1 1122194.AUHU01000003_gene2357 8.02e-93 299.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,464X3@72275|Alteromonadaceae 1236|Gammaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_860528_2 436308.Nmar_0047 2.46e-42 149.0 COG1819@1|root,arCOG01393@2157|Archaea,41SZK@651137|Thaumarchaeota 651137|Thaumarchaeota G Glycosyl transferase family 1 - - - - - - - - - - - - - k59_464067_1 402881.Plav_2680 1.72e-51 179.0 COG3653@1|root,COG3653@2|Bacteria,1MWWY@1224|Proteobacteria,2TSZZ@28211|Alphaproteobacteria 28211|Alphaproteobacteria Q COG3653 N-acyl-D-aspartate D-glutamate deacylase - - - - - - - - - - - - Amidohydro_1,Amidohydro_3 k59_464067_2 1254432.SCE1572_13755 1.03e-19 91.3 COG2175@1|root,COG2175@2|Bacteria,1Q0C7@1224|Proteobacteria,433XH@68525|delta/epsilon subdivisions,2X2FU@28221|Deltaproteobacteria,2YXR6@29|Myxococcales 28221|Deltaproteobacteria Q Taurine catabolism dioxygenase TauD, TfdA family - - - - - - - - - - - - TauD k59_1141936_1 402881.Plav_3132 3.02e-79 251.0 COG0245@1|root,COG1211@1|root,COG0245@2|Bacteria,COG1211@2|Bacteria,1MVHA@1224|Proteobacteria,2TRQC@28211|Alphaproteobacteria,1JN5U@119043|Rhodobiaceae 28211|Alphaproteobacteria I Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl- D-erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2- phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4- cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF) ispDF - 2.7.7.60,4.6.1.12 ko:K01770,ko:K12506 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05633,R05637 RC00002,RC01440 ko00000,ko00001,ko00002,ko01000 - - - IspD,YgbB k59_1141936_2 579138.Zymop_0169 1.95e-08 54.7 COG0042@1|root,COG0042@2|Bacteria,1MV5V@1224|Proteobacteria,2TRC8@28211|Alphaproteobacteria,2K0QH@204457|Sphingomonadales 204457|Sphingomonadales J Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines - - - ko:K05540 - - - - ko00000,ko01000,ko03016 - - - Dus k59_351707_1 1117647.M5M_02135 3.79e-108 327.0 COG0155@1|root,COG0155@2|Bacteria,1MVVB@1224|Proteobacteria,1RMFH@1236|Gammaproteobacteria,1J4DA@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C COG0155 Sulfite reductase, beta subunit (hemoprotein) cysI - 1.8.1.2 ko:K00381 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00176 R00858 RC00065 ko00000,ko00001,ko00002,ko01000 - - - NIR_SIR,NIR_SIR_ferr k59_1312057_1 693986.MOC_3610 6.4e-47 186.0 COG4643@1|root,COG5545@1|root,COG4643@2|Bacteria,COG5545@2|Bacteria,1QZ04@1224|Proteobacteria,2TY2W@28211|Alphaproteobacteria 28211|Alphaproteobacteria L DNA primase activity - - - - - - - - - - - - - k59_860544_1 1121937.AUHJ01000004_gene1065 1.85e-36 134.0 COG0189@1|root,COG0189@2|Bacteria,1MVDU@1224|Proteobacteria,1RR7D@1236|Gammaproteobacteria,464QG@72275|Alteromonadaceae 1236|Gammaproteobacteria HJ COG0189 Glutathione synthase Ribosomal protein S6 modification enzyme (glutaminyl transferase) PA1766 - - - - - - - - - - - ATPgrasp_ST k59_860544_2 1027273.GZ77_04815 3.66e-11 63.2 COG1305@1|root,COG1305@2|Bacteria,1MVV3@1224|Proteobacteria,1RRIA@1236|Gammaproteobacteria,1XI8H@135619|Oceanospirillales 135619|Oceanospirillales E 7 transmembrane helices usually fused to an inactive transglutaminase - - - - - - - - - - - - 7TM_transglut,Transglut_i_TM k59_1481986_1 1120949.KB903298_gene5824 0.000135 48.9 COG5001@1|root,COG5001@2|Bacteria,2GIZF@201174|Actinobacteria,4DH3D@85008|Micromonosporales 201174|Actinobacteria T Signal transduction protein containing a membrane domain an EAL and a GGDEF domain - - - - - - - - - - - - EAL,GGDEF k59_237883_1 690850.Desaf_1798 2.61e-12 72.8 COG3677@1|root,COG3677@2|Bacteria,1RFKN@1224|Proteobacteria,42RGK@68525|delta/epsilon subdivisions,2WNW7@28221|Deltaproteobacteria,2M7QY@213115|Desulfovibrionales 28221|Deltaproteobacteria L Transposase zinc-ribbon domain - - - ko:K07488 - - - - ko00000 - - - DDE_Tnp_IS1595,Zn_Tnp_IS1595 k59_125487_1 426117.M446_5885 8.63e-10 70.5 COG2114@1|root,COG3899@1|root,COG3903@1|root,COG2114@2|Bacteria,COG3899@2|Bacteria,COG3903@2|Bacteria,1MUDT@1224|Proteobacteria,2TQVN@28211|Alphaproteobacteria,1JR57@119045|Methylobacteriaceae 28211|Alphaproteobacteria T Adenylate and Guanylate cyclase catalytic domain - - - - - - - - - - - - AAA_16,DZR,Guanylate_cyc,SAM_1,SAM_2 k59_125487_2 103733.JNYO01000021_gene6767 1.66e-48 168.0 COG3866@1|root,COG3866@2|Bacteria,2GNKW@201174|Actinobacteria,4E1TN@85010|Pseudonocardiales 201174|Actinobacteria G Amb_all - - 4.2.2.2 ko:K01728 ko00040,ko02024,map00040,map02024 - R02361,R06240 RC00049,RC00705 ko00000,ko00001,ko01000 - - - DUF1080,Pec_lyase_C k59_1706702_2 314285.KT71_02492 1.78e-62 197.0 COG3917@1|root,COG3917@2|Bacteria,1RA6I@1224|Proteobacteria,1SN4M@1236|Gammaproteobacteria,1J7NT@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria Q DSBA-like thioredoxin domain - - - - - - - - - - - - DSBA k59_351721_1 224911.27350979 9.93e-49 175.0 COG1014@1|root,COG4231@1|root,COG1014@2|Bacteria,COG4231@2|Bacteria,1MUKS@1224|Proteobacteria,2TSHH@28211|Alphaproteobacteria,3JSRZ@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria C Pyruvate ferredoxin/flavodoxin oxidoreductase MA20_17555 - 1.2.7.8 ko:K04090 - - - - br01601,ko00000,ko01000 - - - POR,TPP_enzyme_C k59_351721_2 1120949.KB903313_gene494 3.98e-54 175.0 COG0251@1|root,COG0251@2|Bacteria,2GQ40@201174|Actinobacteria 201174|Actinobacteria J YjgF/chorismate_mutase-like, putative endoribonuclease - - - - - - - - - - - - YjgF_endoribonc k59_351721_3 666509.RCA23_c06770 6.78e-43 155.0 COG0665@1|root,COG0665@2|Bacteria,1MVIZ@1224|Proteobacteria,2TRT9@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Oxidative deamination of D-amino acids dadA GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006082,GO:0006520,GO:0006522,GO:0006524,GO:0006807,GO:0008150,GO:0008152,GO:0008718,GO:0009056,GO:0009063,GO:0009078,GO:0009080,GO:0009987,GO:0016020,GO:0016054,GO:0016491,GO:0016638,GO:0019478,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044464,GO:0046144,GO:0046395,GO:0046416,GO:0046436,GO:0055114,GO:0055130,GO:0071704,GO:0071944,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 1.4.5.1 ko:K00285 ko00360,map00360 - R01374,R09493 RC00006,RC00025 ko00000,ko00001,ko01000 - - - DAO k59_520216_1 158500.BV97_02602 3.35e-89 279.0 COG0248@1|root,COG0248@2|Bacteria,1MV35@1224|Proteobacteria,2TR1W@28211|Alphaproteobacteria,2JZYK@204457|Sphingomonadales 204457|Sphingomonadales FP exopolyphosphatase - - 3.6.1.11,3.6.1.40 ko:K01524 ko00230,map00230 - R03409 RC00002 ko00000,ko00001,ko01000 - - - Ppx-GppA k59_1706708_1 1454004.AW11_02857 1.33e-95 295.0 COG0651@1|root,COG0651@2|Bacteria,1MV6V@1224|Proteobacteria 1224|Proteobacteria CP formate hydrogenlyase subunit 3 multisubunit Na H antiporter, MnhD subunit nuoL3 - - ko:K05568,ko:K12137 - - - - ko00000,ko01000,ko02000 2.A.63.1,2.A.63.2 - - Proton_antipo_M k59_125493_1 1229909.NSED_07280 4.64e-115 333.0 COG0638@1|root,arCOG00971@2157|Archaea,41SYA@651137|Thaumarchaeota 651137|Thaumarchaeota O Proteasome endopeptidase complex - - 3.4.25.1 ko:K03432 ko03050,map03050 M00342,M00343 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03051 - - - Proteasome,Proteasome_A_N k59_1537915_2 1229909.NSED_02115 3.52e-21 91.7 COG1503@1|root,arCOG01742@2157|Archaea 1229909.NSED_02115|- J Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA - - - ko:K03265 ko03015,map03015 - - - ko00000,ko00001,ko03012,ko03019 - - - - k59_1312079_1 1122137.AQXF01000001_gene3053 1.62e-58 186.0 COG3672@1|root,COG3672@2|Bacteria,1RDQS@1224|Proteobacteria,2TTZT@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Bacterial transglutaminase-like cysteine proteinase BTLCP - - - - - - - - - - - - Peptidase_C93 k59_1312079_2 1122137.AQXF01000001_gene3052 2.93e-43 153.0 COG2200@1|root,COG2200@2|Bacteria,1R5R6@1224|Proteobacteria,2TU0I@28211|Alphaproteobacteria 28211|Alphaproteobacteria T EAL domain - - - - - - - - - - - - EAL k59_1482001_1 1121937.AUHJ01000001_gene580 1.3e-122 364.0 COG1362@1|root,COG1362@2|Bacteria,1NT1D@1224|Proteobacteria,1RPHR@1236|Gammaproteobacteria,46614@72275|Alteromonadaceae 1236|Gammaproteobacteria E M18 family aminopeptidase apeB GO:0003674,GO:0003824,GO:0004177,GO:0005488,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0008270,GO:0016787,GO:0019538,GO:0043167,GO:0043169,GO:0043170,GO:0044238,GO:0046872,GO:0046914,GO:0070011,GO:0071704,GO:0140096,GO:1901564 3.4.11.21 ko:K01267 - - - - ko00000,ko01000,ko01002,ko04131 - - - Peptidase_M18 k59_520217_1 1122137.AQXF01000003_gene1889 3.31e-130 374.0 COG0483@1|root,COG0483@2|Bacteria,1MUQT@1224|Proteobacteria,2TR06@28211|Alphaproteobacteria 28211|Alphaproteobacteria G Inositol monophosphatase suhB - 3.1.3.25 ko:K01092 ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070 M00131 R01185,R01186,R01187 RC00078 ko00000,ko00001,ko00002,ko01000 - - - Inositol_P k59_520217_2 1333998.M2A_3079 4.86e-12 63.5 COG0231@1|root,COG0231@2|Bacteria,1MW2J@1224|Proteobacteria,2TUWE@28211|Alphaproteobacteria,4BQD3@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria J Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase efp - - ko:K02356 - - - - ko00000,ko03012 - - - EFP,EFP_N,Elong-fact-P_C k59_125494_1 1125863.JAFN01000001_gene2937 9.64e-92 281.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions 1224|Proteobacteria T two component, sigma54 specific, transcriptional regulator, Fis family - - - - - - - - - - - - HTH_8,Response_reg,Sigma54_activat k59_1141955_1 404589.Anae109_2583 5.88e-12 70.9 COG0613@1|root,COG0613@2|Bacteria,1Q692@1224|Proteobacteria,432NB@68525|delta/epsilon subdivisions,2WXVS@28221|Deltaproteobacteria 28221|Deltaproteobacteria S PHP domain protein - - - - - - - - - - - - - k59_1141955_2 204773.HEAR0049 4.77e-28 114.0 COG2194@1|root,COG2194@2|Bacteria,1MWS7@1224|Proteobacteria,2VJHS@28216|Betaproteobacteria,473BJ@75682|Oxalobacteraceae 28216|Betaproteobacteria S Domain of unknown function (DUF1705) - - 2.7.8.43 ko:K03760 ko01503,map01503 M00722 R11555,R11556,R11557 RC00002 ko00000,ko00001,ko00002,ko01000,ko01005 - - - DUF1705,PAP2,Sulfatase k59_1706712_1 1336235.JAEG01000001_gene2463 1.76e-103 332.0 COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,1MV6G@1224|Proteobacteria,2TQTG@28211|Alphaproteobacteria,4B8M0@82115|Rhizobiaceae 28211|Alphaproteobacteria E Methionine synthase metH GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006464,GO:0006479,GO:0006520,GO:0006555,GO:0006575,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0008213,GO:0008270,GO:0008276,GO:0008652,GO:0008705,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0019538,GO:0019752,GO:0019842,GO:0031419,GO:0032259,GO:0034641,GO:0035999,GO:0036094,GO:0036211,GO:0042084,GO:0042558,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043414,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046653,GO:0046872,GO:0046906,GO:0046914,GO:0048037,GO:0050667,GO:0051186,GO:0071704,GO:0097159,GO:0140096,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.1.1.13 ko:K00548 ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230 M00017 R00946,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 - - - B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans k59_1482003_1 1288826.MSNKSG1_00526 3.43e-78 248.0 COG0056@1|root,COG0056@2|Bacteria,1MVHM@1224|Proteobacteria,1RMVT@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit atpA1 - 3.6.3.14 ko:K02111 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - - ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N k59_803725_2 580332.Slit_2492 1.48e-71 222.0 COG0745@1|root,COG0745@2|Bacteria,1MY5Y@1224|Proteobacteria,2VI0W@28216|Betaproteobacteria,44WD1@713636|Nitrosomonadales 28216|Betaproteobacteria K Two component transcriptional regulator, winged helix family basR_3 - - ko:K02483,ko:K07666,ko:K07774 ko02020,ko02024,map02020,map02024 M00453,M00457 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Trans_reg_C k59_577197_1 1121897.AUGO01000006_gene730 3.03e-114 338.0 COG1609@1|root,COG1609@2|Bacteria,4NDW6@976|Bacteroidetes,1HY65@117743|Flavobacteriia,2NUUI@237|Flavobacterium 976|Bacteroidetes K helix_turn _helix lactose operon repressor - - - ko:K02529 - - - - ko00000,ko03000 - - - LacI,Peripla_BP_1,Peripla_BP_3 k59_1594043_1 448385.sce2589 7.01e-213 603.0 COG4799@1|root,COG4799@2|Bacteria,1MVAX@1224|Proteobacteria,42N6D@68525|delta/epsilon subdivisions,2X5IJ@28221|Deltaproteobacteria,2YWT3@29|Myxococcales 28221|Deltaproteobacteria I Carboxyl transferase domain - - - - - - - - - - - - Carboxyl_trans k59_1537945_1 1183377.Py04_0316 0.000449 47.8 COG1011@1|root,arCOG02291@2157|Archaea,2Y2YA@28890|Euryarchaeota,245CW@183968|Thermococci 183968|Thermococci S Haloacid dehalogenase-like hydrolase - - - ko:K07025 - - - - ko00000 - - - HAD_2 k59_1030129_1 1131266.ARWQ01000006_gene233 6.83e-58 184.0 arCOG05400@1|root,arCOG05400@2157|Archaea,41SQH@651137|Thaumarchaeota 651137|Thaumarchaeota S PFAM Polyketide cyclase dehydrase and lipid transport - - - - - - - - - - - - Polyketide_cyc2 k59_1706748_1 199310.c3710 4.3e-124 357.0 COG2186@1|root,COG2186@2|Bacteria,1R8M2@1224|Proteobacteria,1RZIJ@1236|Gammaproteobacteria,3XPCH@561|Escherichia 1236|Gammaproteobacteria K Activator for the glycolate oxidation locus glcC GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2000112,GO:2001141 - ko:K05799,ko:K11474 - - - - ko00000,ko03000 - - - FCD,GntR k59_1706748_2 754331.AEME01000001_gene2543 5.27e-15 73.2 COG0454@1|root,COG0456@2|Bacteria,1PMA3@1224|Proteobacteria,1RS1U@1236|Gammaproteobacteria,3XPHS@561|Escherichia 1236|Gammaproteobacteria K acetyltransferase yghO GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031326,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1903506,GO:2000112,GO:2001141 - - - - - - - - - - - k59_1198625_1 1192868.CAIU01000019_gene2653 8.12e-77 248.0 COG1233@1|root,COG1233@2|Bacteria,1MV2R@1224|Proteobacteria,2TSR0@28211|Alphaproteobacteria,43GY1@69277|Phyllobacteriaceae 28211|Alphaproteobacteria Q Flavin containing amine oxidoreductase - - - - - - - - - - - - Amino_oxidase,NAD_binding_8 k59_860609_1 436308.Nmar_1684 2.08e-10 61.2 arCOG08795@1|root,arCOG08795@2157|Archaea 2157|Archaea C copper ion binding - - - - - - - - - - - - - k59_1491929_1 1231391.AMZF01000013_gene2598 8.19e-126 372.0 COG0165@1|root,COG0165@2|Bacteria,1MUTU@1224|Proteobacteria,2VH47@28216|Betaproteobacteria,3T2HS@506|Alcaligenaceae 28216|Betaproteobacteria E Catalyzes the formation of arginine from (N-L-arginino)succinate argH - 4.3.2.1 ko:K01755 ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230 M00029,M00844,M00845 R01086 RC00445,RC00447 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ASL_C2,Lyase_1 k59_642922_1 1122135.KB893134_gene3124 9.81e-65 205.0 COG1177@1|root,COG1177@2|Bacteria,1MVC5@1224|Proteobacteria,2TRRJ@28211|Alphaproteobacteria 28211|Alphaproteobacteria E ABC-type spermidine putrescine transport system, permease component II potI - - ko:K11074 ko02010,map02010 M00300 - - ko00000,ko00001,ko00002,ko02000 3.A.1.11.2 - - BPD_transp_1 k59_642922_2 565045.NOR51B_122 3.68e-65 209.0 COG4638@1|root,COG4638@2|Bacteria,1MWXW@1224|Proteobacteria,1RQ0P@1236|Gammaproteobacteria,1JA4R@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P COG4638 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit - - - - - - - - - - - - Rieske,Ring_hydroxyl_A k59_473323_2 396588.Tgr7_0954 3.83e-16 77.0 COG0500@1|root,COG2226@2|Bacteria,1QTWC@1224|Proteobacteria,1RS4G@1236|Gammaproteobacteria,1WXQH@135613|Chromatiales 135613|Chromatiales Q PFAM methyltransferase - - - - - - - - - - - - Methyltransf_11 k59_362177_1 1049564.TevJSym_bb00010 2.05e-70 220.0 COG2878@1|root,COG2878@2|Bacteria,1NZIR@1224|Proteobacteria,1RPC4@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Fe-S cluster - - - ko:K03616 - - - - ko00000 - - - FeS,Fer4 k59_362177_2 1049564.TevJSym_bb00030 6.8e-30 118.0 COG1013@1|root,COG1013@2|Bacteria,1R28U@1224|Proteobacteria 1224|Proteobacteria C 4fe-4S ferredoxin, iron-sulfur binding domain protein - - - - - - - - - - - - TPP_enzyme_C k59_1378821_1 1382356.JQMP01000004_gene486 9.99e-157 473.0 COG0366@1|root,COG3281@1|root,COG0366@2|Bacteria,COG3281@2|Bacteria,2G86T@200795|Chloroflexi,27XQK@189775|Thermomicrobia 189775|Thermomicrobia G Alpha-amylase domain - - 3.2.1.1,5.4.99.16 ko:K05343 ko00500,ko01100,map00500,map01100 - R01557,R02108,R02112,R11262 RC01816 ko00000,ko00001,ko01000 - GH13 - APH,Alpha-amylase,Malt_amylase_C k59_925532_2 436308.Nmar_0807 7.21e-50 159.0 COG0089@1|root,arCOG04072@2157|Archaea,41SS4@651137|Thaumarchaeota 651137|Thaumarchaeota J Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome rpl23 - - ko:K02892 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L23 k59_925532_3 436308.Nmar_0808 1.14e-31 117.0 COG0469@1|root,arCOG04071@2157|Archaea,41SHB@651137|Thaumarchaeota 651137|Thaumarchaeota J Ribosomal protein L4 - - - ko:K02930 ko03010,map03010 M00177,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L4 k59_1548219_1 876269.ARWA01000001_gene1098 3.73e-24 102.0 COG0243@1|root,COG0243@2|Bacteria,1NS3T@1224|Proteobacteria,2TQYD@28211|Alphaproteobacteria,3NADM@45404|Beijerinckiaceae 28211|Alphaproteobacteria C Molydopterin dinucleotide binding domain nasA - - ko:K00372 ko00910,ko01120,map00910,map01120 M00531 R00798,R01106 RC02812 ko00000,ko00001,ko00002,ko01000 - - - Fer2_BFD,Molybdop_Fe4S4,Molybdopterin,Molydop_binding k59_1548219_2 627192.SLG_27710 3.6e-41 139.0 COG2146@1|root,COG2146@2|Bacteria,1N03R@1224|Proteobacteria,2UC33@28211|Alphaproteobacteria,2K5EE@204457|Sphingomonadales 204457|Sphingomonadales P Nitrite reductase nirD - 1.7.1.15 ko:K00363 ko00910,ko01120,map00910,map01120 M00530 R00787 RC00176 ko00000,ko00001,ko00002,ko01000 - - - Rieske,Rieske_2 k59_1548219_3 1158146.KB907125_gene2325 2.73e-10 60.8 COG1251@1|root,COG1251@2|Bacteria,1MW58@1224|Proteobacteria,1RNGY@1236|Gammaproteobacteria,1WWFC@135613|Chromatiales 135613|Chromatiales C Pyridine nucleotide-disulphide oxidoreductase - - 1.18.1.1,1.7.1.15 ko:K00362,ko:K05297 ko00071,ko00910,ko01120,map00071,map00910,map01120 M00530 R00787,R02000 RC00176 ko00000,ko00001,ko00002,ko01000 - - - Fer2_BFD,NIR_SIR,NIR_SIR_ferr,Pyr_redox_2 k59_700279_1 1046627.BZARG_897 1.41e-88 291.0 COG2373@1|root,COG2373@2|Bacteria,4NED2@976|Bacteroidetes,1HWJJ@117743|Flavobacteriia 976|Bacteroidetes P Large extracellular alpha-helical protein - - - - - - - - - - - - A2M,A2M_N,A2M_N_2,CarbopepD_reg_2 k59_700283_1 555793.WSK_0384 6.06e-56 180.0 COG1386@1|root,COG1386@2|Bacteria,1PUA6@1224|Proteobacteria,2TU64@28211|Alphaproteobacteria,2K231@204457|Sphingomonadales 204457|Sphingomonadales D Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves scpB - - ko:K06024 - - - - ko00000,ko03036 - - - SMC_ScpB k59_700283_2 702113.PP1Y_AT5446 6.7e-26 97.4 COG1826@1|root,COG1826@2|Bacteria,1NGDP@1224|Proteobacteria,2UFBN@28211|Alphaproteobacteria,2K6TA@204457|Sphingomonadales 204457|Sphingomonadales U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system tatA - - ko:K03116 ko03060,ko03070,map03060,map03070 M00336 - - ko00000,ko00001,ko00002,ko02044 2.A.64 - - MttA_Hcf106 k59_1660676_3 399795.CtesDRAFT_PD3391 6.59e-204 590.0 COG0270@1|root,COG0270@2|Bacteria,1P5BJ@1224|Proteobacteria,2VK6K@28216|Betaproteobacteria,4AJD0@80864|Comamonadaceae 28216|Betaproteobacteria L C-5 cytosine-specific DNA methylase - - - - - - - - - - - - DNA_methylase k59_1660676_4 640511.BC1002_7203 1.03e-40 151.0 COG0420@1|root,COG0420@2|Bacteria,1R4BI@1224|Proteobacteria,2VMUR@28216|Betaproteobacteria,1JZQ4@119060|Burkholderiaceae 28216|Betaproteobacteria L 3'-5' exonuclease activity - - - ko:K03547 - - - - ko00000,ko03400 - - - Metallophos_2 k59_305564_1 335283.Neut_1519 1.43e-09 55.8 COG0425@1|root,COG0425@2|Bacteria,1MZA5@1224|Proteobacteria,2VVW5@28216|Betaproteobacteria,373FP@32003|Nitrosomonadales 28216|Betaproteobacteria O Belongs to the sulfur carrier protein TusA family - - - ko:K04085 ko04122,map04122 - - - ko00000,ko00001,ko01000,ko03016 - - - TusA k59_305564_2 1122137.AQXF01000001_gene2934 7.15e-149 423.0 COG2771@1|root,COG2771@2|Bacteria 2|Bacteria K luxR family rcsA - - ko:K07781 ko02020,ko02024,ko02026,map02020,map02024,map02026 - - - ko00000,ko00001,ko03000 - - - GerE k59_305564_4 1122137.AQXF01000001_gene2932 1.47e-41 143.0 COG0132@1|root,COG0132@2|Bacteria,1RDRK@1224|Proteobacteria,2U5AJ@28211|Alphaproteobacteria 28211|Alphaproteobacteria H Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring bioD GO:0003674,GO:0003824,GO:0004141,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016882,GO:0017144,GO:0018130,GO:0019752,GO:0032787,GO:0034641,GO:0042364,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.1.197,6.3.3.3 ko:K01935,ko:K02169 ko00780,ko01100,map00780,map01100 M00123,M00572,M00573,M00577 R03182,R09543 RC00003,RC00460,RC00868 ko00000,ko00001,ko00002,ko01000 - - - AAA_26 k59_812767_1 316407.85675896 6.09e-25 95.5 2E956@1|root,333DY@2|Bacteria,1RFWN@1224|Proteobacteria,1S4DF@1236|Gammaproteobacteria,3XPRQ@561|Escherichia 1236|Gammaproteobacteria S Modulates the activity of the EnvZ OmpR two-component regulatory system, probably by directly modulating EnvZ enzymatic activity and increasing stability of phosphorylated OmpR mzrA GO:0001932,GO:0008150,GO:0019220,GO:0019222,GO:0031323,GO:0031399,GO:0032268,GO:0042325,GO:0043549,GO:0045859,GO:0050789,GO:0050790,GO:0050794,GO:0051171,GO:0051174,GO:0051246,GO:0051338,GO:0060255,GO:0065007,GO:0065009,GO:0080090 - - - - - - - - - - SecD-TM1 k59_812767_2 316407.85675895 4.77e-93 275.0 COG0586@1|root,COG0586@2|Bacteria,1MU30@1224|Proteobacteria,1RNS5@1236|Gammaproteobacteria,3XPA0@561|Escherichia 1236|Gammaproteobacteria S Inner membrane protein YqjA yqjA GO:0000003,GO:0000910,GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0007049,GO:0008150,GO:0009987,GO:0016020,GO:0019954,GO:0022402,GO:0022414,GO:0022857,GO:0032505,GO:0043093,GO:0044464,GO:0051179,GO:0051234,GO:0051301,GO:0055085,GO:0071944 - - - - - - - - - - SNARE_assoc k59_191562_1 1502850.FG91_00575 1.32e-65 230.0 COG1629@1|root,COG4773@1|root,COG1629@2|Bacteria,COG4773@2|Bacteria,1R479@1224|Proteobacteria,2TV3V@28211|Alphaproteobacteria,2K147@204457|Sphingomonadales 28211|Alphaproteobacteria P COG1629 Outer membrane receptor proteins, mostly Fe transport - - - - - - - - - - - - Plug,TonB_dep_Rec k59_22608_1 1380384.JADN01000008_gene1074 3.07e-05 43.5 COG0316@1|root,COG0316@2|Bacteria,4NQC8@976|Bacteroidetes,1I2SJ@117743|Flavobacteriia 976|Bacteroidetes S Belongs to the HesB IscA family sufA - - ko:K13628 - - - - ko00000,ko03016 - - - Fe-S_biosyn k59_22608_2 411901.BACCAC_01037 3.66e-11 65.9 2E5XB@1|root,330M9@2|Bacteria,4NW0P@976|Bacteroidetes,2FS56@200643|Bacteroidia,4AR5Q@815|Bacteroidaceae 976|Bacteroidetes S COG NOG30135 non supervised orthologous group - - - - - - - - - - - - DUF4251 k59_22608_3 1041826.FCOL_09265 1.35e-13 70.1 COG0611@1|root,COG0611@2|Bacteria,4NDUT@976|Bacteroidetes,1HWNB@117743|Flavobacteriia,2NUPR@237|Flavobacterium 976|Bacteroidetes H Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 thiL - 2.7.4.16 ko:K00946 ko00730,ko01100,map00730,map01100 M00127 R00617 RC00002 ko00000,ko00001,ko00002,ko01000 - - - AIRS,AIRS_C k59_1208743_1 1484460.JSWG01000015_gene1144 9.6e-80 248.0 COG0179@1|root,COG0179@2|Bacteria,4NGI0@976|Bacteroidetes,1HXN9@117743|Flavobacteriia 976|Bacteroidetes Q Fumarylacetoacetase fahA - 3.7.1.2 ko:K01555 ko00350,ko00643,ko01100,ko01120,map00350,map00643,map01100,map01120 M00044 R01364 RC00326,RC00446 ko00000,ko00001,ko00002,ko01000,ko04147 - - - FAA_hydrolase,FAA_hydrolase_N k59_1208743_2 946077.W5A_11414 5.01e-111 330.0 COG0112@1|root,COG0112@2|Bacteria,4NE30@976|Bacteroidetes,1HXUW@117743|Flavobacteriia 976|Bacteroidetes E Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism glyA - 2.1.2.1 ko:K00600 ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523 M00140,M00141,M00346,M00532 R00945,R09099 RC00022,RC00112,RC01583,RC02958 ko00000,ko00001,ko00002,ko01000 - - - SHMT k59_1548238_1 1211819.CALK01000009_gene2859 5.03e-12 65.1 COG0396@1|root,COG0396@2|Bacteria,1TQ98@1239|Firmicutes,3VP09@526524|Erysipelotrichia 526524|Erysipelotrichia O FeS assembly ATPase SufC sufC - - ko:K09013 - - - - ko00000,ko02000 - - - ABC_tran k59_1548238_2 671143.DAMO_2383 1.05e-233 652.0 COG0719@1|root,COG0719@2|Bacteria,2NNKT@2323|unclassified Bacteria 2|Bacteria O FeS assembly protein SufB sufB GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006790,GO:0008150,GO:0008152,GO:0009536,GO:0009842,GO:0009987,GO:0016043,GO:0016226,GO:0022607,GO:0031163,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044085,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0051186,GO:0051536,GO:0051537,GO:0051539,GO:0051540,GO:0071840 - ko:K07033,ko:K09014 - - - - ko00000 - - iAPECO1_1312.APECO1_760,iECH74115_1262.ECH74115_2397,iECSF_1327.ECSF_1543,iECSP_1301.ECSP_2250,iUTI89_1310.UTI89_C1875,ic_1306.c2078 UPF0051 k59_362215_2 589865.DaAHT2_0222 6.38e-23 100.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,42PTS@68525|delta/epsilon subdivisions,2WTHY@28221|Deltaproteobacteria,2MMXZ@213118|Desulfobacterales 28221|Deltaproteobacteria T GGDEF domain containing protein - - - - - - - - - - - - EAL,GGDEF k59_135525_1 1229205.BUPH_03910 6.11e-42 155.0 COG2609@1|root,COG2609@2|Bacteria,1MV21@1224|Proteobacteria,2VHP1@28216|Betaproteobacteria,1K4GC@119060|Burkholderiaceae 28216|Betaproteobacteria C Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) aceE1 GO:0000287,GO:0003674,GO:0003824,GO:0004738,GO:0005488,GO:0005515,GO:0008150,GO:0008152,GO:0016491,GO:0016903,GO:0019842,GO:0030976,GO:0036094,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043169,GO:0046872,GO:0046983,GO:0048037,GO:0050662,GO:0055114,GO:0097159,GO:1901363,GO:1901681 1.2.4.1 ko:K00163 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200 M00307 R00014,R00209,R01699,R03270 RC00004,RC00027,RC00627,RC02742,RC02744,RC02882 br01601,ko00000,ko00001,ko00002,ko01000 - - - Transketolase_C,Transketolase_N k59_1094971_1 504487.JCM19302_1220 4.29e-171 498.0 COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,4NFBK@976|Bacteroidetes,1HY8A@117743|Flavobacteriia 976|Bacteroidetes EU peptidase S9 - - - - - - - - - - - - Peptidase_S9 k59_1151900_1 220664.PFL_0831 1.1e-123 382.0 COG0458@1|root,COG0458@2|Bacteria,1MUDZ@1224|Proteobacteria,1RPIU@1236|Gammaproteobacteria,1YP5N@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria F Carbamoyl-phosphate synthetase ammonia chain carB GO:0000050,GO:0000166,GO:0003674,GO:0003824,GO:0004087,GO:0004088,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005951,GO:0006082,GO:0006139,GO:0006206,GO:0006220,GO:0006221,GO:0006520,GO:0006525,GO:0006526,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016053,GO:0016597,GO:0016874,GO:0016879,GO:0016884,GO:0017076,GO:0018130,GO:0019438,GO:0019627,GO:0019637,GO:0019693,GO:0019752,GO:0019856,GO:0030554,GO:0031406,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046112,GO:0046390,GO:0046394,GO:0046483,GO:0046872,GO:0055086,GO:0071704,GO:0071941,GO:0072527,GO:0072528,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494 6.3.5.5 ko:K01955 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - iAF1260.b0033,iBWG_1329.BWG_0031,iECDH10B_1368.ECDH10B_0034,iECDH1ME8569_1439.ECDH1ME8569_0031,iECUMN_1333.ECUMN_0034,iEcDH1_1363.EcDH1_3566,iJN746.PP_4723,iJO1366.b0033,iJR904.b0033,iPC815.YPO0482,iY75_1357.Y75_RS00170,iYL1228.KPN_00041 CPSase_L_D2,CPSase_L_D3,MGS k59_1263980_1 1410650.JHWL01000036_gene656 3.64e-15 80.1 COG2812@1|root,COG2812@2|Bacteria,1VCQC@1239|Firmicutes,248U4@186801|Clostridia,4BWC6@830|Butyrivibrio 186801|Clostridia L DNA polymerase III, delta subunit holB - 2.7.7.7 ko:K02341 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_delta2,DNApol3-delta_C k59_1151906_1 330214.NIDE0866 2.11e-42 147.0 COG2854@1|root,COG2854@2|Bacteria,3J13Z@40117|Nitrospirae 40117|Nitrospirae Q Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - ko:K07323 ko02010,map02010 M00210 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27.3 - - MlaC k59_1433648_1 272943.RSP_3007 1.05e-68 212.0 COG2801@1|root,COG2801@2|Bacteria,1MZ45@1224|Proteobacteria,2TTG7@28211|Alphaproteobacteria 28211|Alphaproteobacteria L InterPro IPR001584 COGs COG2801 - - - - - - - - - - - - HTH_32,rve k59_529099_1 59538.XP_005976537.1 9.64e-32 123.0 COG0621@1|root,KOG2492@2759|Eukaryota,3AA8B@33154|Opisthokonta,3BVCM@33208|Metazoa,3DB6Y@33213|Bilateria 33208|Metazoa J Uncharacterized protein family UPF0054 - - - - - - - - - - - - PhoH,UPF0054 k59_1208764_1 671065.MetMK1DRAFT_00006630 1.39e-63 204.0 COG0175@1|root,arCOG00124@2157|Archaea,2XSNR@28889|Crenarchaeota 28889|Crenarchaeota E Phosphoadenosine phosphosulfate reductase family cysH - 1.8.4.10,1.8.4.8 ko:K00390 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00176 R02021 RC00007,RC02862 ko00000,ko00001,ko00002,ko01000 - - - PAPS_reduct k59_22642_1 382245.ASA_0038 2.73e-11 65.1 COG1718@1|root,COG1718@2|Bacteria,1QV96@1224|Proteobacteria,1T2AM@1236|Gammaproteobacteria,1Y48X@135624|Aeromonadales 135624|Aeromonadales H Catalyzes the ATP-dependent phosphorylation of the 3- deoxy-D-manno-octulosonic acid (Kdo) residue in Kdo-lipid IV(A) at the 4-OH position kdkA - 2.7.1.166 ko:K11211 ko00540,map00540 - R09767 RC00002,RC00078 ko00000,ko00001,ko01000 - - - Kdo k59_22642_2 1123073.KB899241_gene3025 3.19e-26 98.2 COG4391@1|root,COG4391@2|Bacteria,1N7QM@1224|Proteobacteria,1SHHF@1236|Gammaproteobacteria,1X821@135614|Xanthomonadales 135614|Xanthomonadales S protein conserved in bacteria VL23_05015 - - - - - - - - - - - zf-CHCC k59_1717227_1 1333998.M2A_1693 1.67e-162 469.0 COG1960@1|root,COG1960@2|Bacteria,1MVJC@1224|Proteobacteria,2TTRD@28211|Alphaproteobacteria,4BT82@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria I Acyl-CoA dehydrogenase, N-terminal domain - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_587124_1 1229909.NSED_03420 5.8e-33 127.0 COG0457@1|root,arCOG03032@2157|Archaea,41SBD@651137|Thaumarchaeota 651137|Thaumarchaeota S TPR repeat - - - - - - - - - - - - TPR_1,TPR_2,TPR_8 k59_755820_1 158500.BV97_00118 2.97e-83 255.0 COG1816@1|root,COG1816@2|Bacteria,1MWBV@1224|Proteobacteria,2TSBX@28211|Alphaproteobacteria,2K1AI@204457|Sphingomonadales 204457|Sphingomonadales F Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism - - 3.5.4.2 ko:K21053 ko00230,ko01100,map00230,map01100 - R01244 RC00477 ko00000,ko00001,ko01000 - - - A_deaminase k59_305615_1 232346.JHQL01000006_gene3090 4.78e-69 224.0 COG0635@1|root,COG0635@2|Bacteria,1MV1I@1224|Proteobacteria,1RN1Y@1236|Gammaproteobacteria,1XHZ4@135619|Oceanospirillales 135619|Oceanospirillales H Belongs to the anaerobic coproporphyrinogen-III oxidase family hemN - - - - - - - - - - - HemN_C,Radical_SAM k59_1378881_1 675814.VIC_001648 1.27e-122 366.0 COG0028@1|root,COG0028@2|Bacteria,1MWUB@1224|Proteobacteria,1S0VC@1236|Gammaproteobacteria,1XUYJ@135623|Vibrionales 135623|Vibrionales EH Belongs to the TPP enzyme family xsc - 2.3.3.15 ko:K03852 ko00430,map00430 - R05651 RC02903,RC02909 ko00000,ko00001,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_1151935_1 1382230.ASAP_2923 9.91e-36 132.0 COG2896@1|root,COG2896@2|Bacteria,1MW3W@1224|Proteobacteria,2TQQP@28211|Alphaproteobacteria,2JPSN@204441|Rhodospirillales 204441|Rhodospirillales H Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate moaA - 4.1.99.22 ko:K03639 ko00790,ko01100,ko04122,map00790,map01100,map04122 - R09394 RC03420 ko00000,ko00001,ko01000 - - - Fer4_12,Mob_synth_C,Radical_SAM k59_1717242_1 1121405.dsmv_1239 6.79e-65 215.0 COG1283@1|root,COG1283@2|Bacteria,1MUDE@1224|Proteobacteria,42PW9@68525|delta/epsilon subdivisions,2WJTI@28221|Deltaproteobacteria,2MJ12@213118|Desulfobacterales 28221|Deltaproteobacteria P PFAM Na Pi-cotransporter - - - ko:K03324 - - - - ko00000,ko02000 2.A.58.2 - - Na_Pi_cotrans k59_417662_1 330214.NIDE0800 9.1e-05 44.3 COG0571@1|root,COG0571@2|Bacteria,3J119@40117|Nitrospirae 40117|Nitrospirae J Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism - - 3.1.26.3 ko:K03685 ko03008,ko05205,map03008,map05205 - - - ko00000,ko00001,ko01000,ko03009,ko03019,ko03036 - - - Ribonucleas_3_3,dsrm k59_417662_2 330214.NIDE0801 1.14e-76 236.0 COG0652@1|root,COG0652@2|Bacteria,3J18H@40117|Nitrospirae 40117|Nitrospirae O PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides - - 5.2.1.8 ko:K03767,ko:K03768 ko01503,ko04217,map01503,map04217 - - - ko00000,ko00001,ko01000,ko03110,ko04147 - - - Pro_isomerase k59_1548285_1 247634.GPB2148_3480 1.04e-19 86.3 28IGK@1|root,2Z8I1@2|Bacteria,1RAH7@1224|Proteobacteria,1RPTY@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_1548285_2 247634.GPB2148_3830 1.1e-109 319.0 COG4508@1|root,COG4508@2|Bacteria,1RAX1@1224|Proteobacteria,1RYFG@1236|Gammaproteobacteria,1J5W3@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S dUTPase dut - - - - - - - - - - - dUTPase_2 k59_1548285_3 1121937.AUHJ01000009_gene1479 9.74e-15 73.6 COG0527@1|root,COG0527@2|Bacteria,1MW3H@1224|Proteobacteria,1RN1G@1236|Gammaproteobacteria,465C7@72275|Alteromonadaceae 1236|Gammaproteobacteria E Belongs to the aspartokinase family thrA GO:0003674,GO:0003824,GO:0004072,GO:0004412,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006553,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009070,GO:0009085,GO:0009089,GO:0009090,GO:0009092,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016491,GO:0016614,GO:0016616,GO:0016740,GO:0016772,GO:0016774,GO:0019202,GO:0019752,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.3,2.7.2.4 ko:K12524,ko:K12525 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00017,M00018,M00526,M00527 R00480,R01773,R01775 RC00002,RC00043,RC00087 ko00000,ko00001,ko00002,ko01000 - - iECDH1ME8569_1439.ECDH1ME8569_0002,iEcDH1_1363.EcDH1_3594,iSFV_1184.SFV_0001,iUMNK88_1353.UMNK88_4778,iYL1228.KPN_04234 AA_kinase,ACT,ACT_7,Homoserine_dh,NAD_binding_3 k59_22658_1 997346.HMPREF9374_0322 5.49e-86 266.0 COG1071@1|root,COG1071@2|Bacteria,1TQDG@1239|Firmicutes,4HBEQ@91061|Bacilli,27BD0@186824|Thermoactinomycetaceae 91061|Bacilli C Dehydrogenase E1 component bfmBAA - 1.2.4.4 ko:K00166 ko00280,ko00640,ko01100,ko01110,ko01130,map00280,map00640,map01100,map01110,map01130 M00036 R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997 RC00027,RC00627,RC02743,RC02883,RC02949,RC02953 br01601,ko00000,ko00001,ko00002,ko01000 - - iSB619.SA_RS07640 E1_dh k59_22658_2 749414.SBI_05732 5.64e-26 107.0 COG0334@1|root,COG0334@2|Bacteria,2GKXG@201174|Actinobacteria 201174|Actinobacteria E Belongs to the Glu Leu Phe Val dehydrogenases family vdh GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 1.4.1.23 ko:K00271 ko00280,ko01100,ko01110,ko01130,map00280,map01100,map01110,map01130 - R01212,R01434 RC00036 ko00000,ko00001,ko01000 - - - ELFV_dehydrog,ELFV_dehydrog_N k59_700346_1 1485544.JQKP01000002_gene1412 3.02e-89 269.0 2C8XG@1|root,2Z7PK@2|Bacteria,1RA5I@1224|Proteobacteria,2VQGY@28216|Betaproteobacteria,44VSN@713636|Nitrosomonadales 28216|Betaproteobacteria S Protein of unknown function (DUF4197) - - - - - - - - - - - - DUF4197 k59_1040522_1 1210884.HG799463_gene9705 8.83e-77 242.0 COG0714@1|root,COG0714@2|Bacteria,2IX8Y@203682|Planctomycetes 203682|Planctomycetes S ATPase family associated with various cellular activities (AAA) - - - ko:K03924 - - - - ko00000,ko01000 - - - AAA_3 k59_1264015_1 85643.Tmz1t_2951 1.33e-85 263.0 COG1775@1|root,COG1775@2|Bacteria,1NNW9@1224|Proteobacteria,2VV78@28216|Betaproteobacteria,2KXPH@206389|Rhodocyclales 206389|Rhodocyclales E 2-hydroxyglutaryl-CoA dehydratase, D-component - - 1.3.7.8 ko:K04112 ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220 M00541 R02451 RC00002,RC01839 ko00000,ko00001,ko00002,ko01000 - - - HGD-D k59_135591_1 1163617.SCD_n02088 2.87e-93 298.0 COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,2VJIV@28216|Betaproteobacteria 28216|Betaproteobacteria F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides nrdA GO:0000166,GO:0003674,GO:0003824,GO:0004748,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005971,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009262,GO:0009263,GO:0009987,GO:0016491,GO:0016725,GO:0016728,GO:0018130,GO:0019438,GO:0019637,GO:0032991,GO:0034641,GO:0034654,GO:0036094,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046483,GO:0055086,GO:0055114,GO:0061731,GO:0071704,GO:0090407,GO:0097159,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902494,GO:1990204 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - ATP-cone,Ribonuc_red_lgC,Ribonuc_red_lgN k59_1264017_1 247634.GPB2148_1184 1.35e-102 311.0 28H52@1|root,2Z7HQ@2|Bacteria,1MXTF@1224|Proteobacteria,1RN8H@1236|Gammaproteobacteria,1J8US@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Protein of unknown function (DUF1329) - - - - - - - - - - - - DUF1329 k59_925605_1 1124780.ANNU01000032_gene1224 3.11e-69 233.0 COG0841@1|root,COG0841@2|Bacteria,4NDZG@976|Bacteroidetes,47NPA@768503|Cytophagia 976|Bacteroidetes V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_643006_2 1121090.KB894685_gene3885 0.000101 50.8 COG1914@1|root,COG1914@2|Bacteria,1V04N@1239|Firmicutes,4HBF6@91061|Bacilli,1ZF5E@1386|Bacillus 91061|Bacilli P Natural resistance-associated macrophage protein - - - - - - - - - - - - Nramp k59_80029_1 879212.DespoDRAFT_02707 6.65e-15 73.9 COG0459@1|root,COG0459@2|Bacteria,1MURR@1224|Proteobacteria,42M52@68525|delta/epsilon subdivisions,2WIRK@28221|Deltaproteobacteria,2MHPV@213118|Desulfobacterales 28221|Deltaproteobacteria O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions groL - - ko:K04077 ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 - - - Cpn60_TCP1 k59_80029_2 227377.CBU_1719 8.55e-36 124.0 COG0234@1|root,COG0234@2|Bacteria,1MZ2X@1224|Proteobacteria,1S8YR@1236|Gammaproteobacteria,1JEPU@118969|Legionellales 118969|Legionellales O Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter groS GO:0003674,GO:0005488,GO:0005515,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008150,GO:0009987,GO:0010033,GO:0035966,GO:0042221,GO:0043167,GO:0043169,GO:0046872,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0061077 - ko:K04078 - - - - ko00000,ko03029,ko03110 - - - Cpn10 k59_362282_1 368408.Tpen_0093 1.04e-105 327.0 COG0213@1|root,arCOG02013@2157|Archaea,2XPZT@28889|Crenarchaeota 28889|Crenarchaeota F Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO - - 2.4.2.57 ko:K18931 - - R10836,R10837,R10838 RC00063 ko00000,ko01000 - - - CDC48_N,Glycos_trans_3N,Glycos_transf_3,PYNP_C k59_362282_2 436308.Nmar_0674 5.37e-09 56.2 COG0589@1|root,arCOG02053@2157|Archaea,41TB2@651137|Thaumarchaeota 651137|Thaumarchaeota T COG0589 Universal stress protein UspA and related nucleotide-binding proteins - - - - - - - - - - - - Usp k59_587164_1 1123499.KB908026_gene1660 2.19e-67 219.0 COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,2VI01@28216|Betaproteobacteria,2KQ9I@206351|Neisseriales 206351|Neisseriales E Aminotransferase class I and II - - - - - - - - - - - - Aminotran_1_2 k59_925616_1 1249627.D779_2336 5.38e-32 124.0 COG3063@1|root,COG3063@2|Bacteria,1MXPC@1224|Proteobacteria,1RY78@1236|Gammaproteobacteria,1WWUQ@135613|Chromatiales 135613|Chromatiales NU TIGRFAM type IV pilus biogenesis stability protein PilW - - - ko:K02656 - - - - ko00000,ko02035,ko02044 - - - LysM,TPR_10,TPR_14,TPR_16,TPR_17,TPR_19,TPR_2,TPR_6,TPR_7,TPR_8 k59_1433700_1 1250278.JQNQ01000001_gene1184 1.43e-36 141.0 COG3186@1|root,COG3186@2|Bacteria,4NEX5@976|Bacteroidetes,1HX7H@117743|Flavobacteriia 976|Bacteroidetes E Pfam Biopterin-dependent aromatic amino acid hydroxylase phhA - 1.14.16.1 ko:K00500 ko00360,ko00400,ko00790,ko01100,ko01230,map00360,map00400,map00790,map01100,map01230 - R01795,R07211 RC00490 ko00000,ko00001,ko01000 - - - Biopterin_H k59_1321355_1 1504672.669785867 9.01e-100 295.0 COG0491@1|root,COG0491@2|Bacteria,1MU8Q@1224|Proteobacteria,2VGZG@28216|Betaproteobacteria,4A9S4@80864|Comamonadaceae 28216|Betaproteobacteria S Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid gloB - 3.1.2.6 ko:K01069 ko00620,map00620 - R01736 RC00004,RC00137 ko00000,ko00001,ko01000 - - - HAGH_C,Lactamase_B k59_22695_1 686578.AFFX01000005_gene4032 2.13e-42 158.0 COG0439@1|root,COG1038@1|root,COG4799@1|root,COG0439@2|Bacteria,COG1038@2|Bacteria,COG4799@2|Bacteria,1MU4H@1224|Proteobacteria,1RQ9Q@1236|Gammaproteobacteria 1236|Gammaproteobacteria I Biotin carboxylase pyc - - - - - - - - - - - Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2,Carboxyl_trans k59_1208829_1 713586.KB900536_gene1489 1.63e-16 82.0 COG3725@1|root,COG3725@2|Bacteria,1MYFA@1224|Proteobacteria,1SE2J@1236|Gammaproteobacteria,1WZMR@135613|Chromatiales 135613|Chromatiales V Membrane protein required for beta-lactamase induction - - - ko:K03807 - - - - ko00000 - - - AmpE,CobD_Cbib k59_1208829_2 399739.Pmen_0780 2.85e-14 69.7 COG3023@1|root,COG3023@2|Bacteria,1RDHU@1224|Proteobacteria,1S3PG@1236|Gammaproteobacteria,1YEB7@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria V Ami_2 ampD GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006022,GO:0006026,GO:0006027,GO:0006807,GO:0008150,GO:0008152,GO:0008745,GO:0009056,GO:0009057,GO:0009253,GO:0009254,GO:0009392,GO:0016020,GO:0016787,GO:0016810,GO:0016811,GO:0019867,GO:0030203,GO:0043170,GO:0044424,GO:0044464,GO:0061783,GO:0071704,GO:1901135,GO:1901136,GO:1901564,GO:1901565,GO:1901575 3.5.1.28 ko:K01447,ko:K03806 - - R04112 RC00064,RC00141 ko00000,ko01000,ko01011 - - iAF1260.b0110,iB21_1397.B21_00108,iBWG_1329.BWG_0103,iEC55989_1330.EC55989_0103,iECBD_1354.ECBD_3509,iECB_1328.ECB_00109,iECDH10B_1368.ECDH10B_0090,iECDH1ME8569_1439.ECDH1ME8569_0104,iECD_1391.ECD_00109,iECIAI1_1343.ECIAI1_0107,iECO103_1326.ECO103_0110,iECO111_1330.ECO111_0111,iECO26_1355.ECO26_0112,iECSE_1348.ECSE_0110,iECW_1372.ECW_m0107,iEKO11_1354.EKO11_3806,iETEC_1333.ETEC_0106,iEcDH1_1363.EcDH1_3492,iEcE24377_1341.EcE24377A_0112,iEcHS_1320.EcHS_A0114,iEcolC_1368.EcolC_3549,iJO1366.b0110,iSFV_1184.SFV_0101,iSF_1195.SF0107,iSFxv_1172.SFxv_0113,iS_1188.S0109,iUMNK88_1353.UMNK88_108,iWFL_1372.ECW_m0107,iY75_1357.Y75_RS00560 Amidase_2 k59_1493558_1 179408.Osc7112_4342 7.3e-49 168.0 COG0745@1|root,COG2114@1|root,COG0745@2|Bacteria,COG2114@2|Bacteria,1FZXP@1117|Cyanobacteria,1H9FJ@1150|Oscillatoriales 1117|Cyanobacteria T Belongs to the adenylyl cyclase class-4 guanylyl cyclase family - - - - - - - - - - - - Guanylate_cyc,Response_reg k59_1606021_1 743299.Acife_2075 6.35e-17 86.3 2C3QV@1|root,2Z7YP@2|Bacteria,1MXAM@1224|Proteobacteria,1RNIA@1236|Gammaproteobacteria,2NDMH@225057|Acidithiobacillales 225057|Acidithiobacillales S Alginate export - - - - - - - - - - - - Alginate_exp k59_419033_1 199310.c4791 9.39e-136 386.0 COG0543@1|root,COG0543@2|Bacteria,1MV72@1224|Proteobacteria,1RPH5@1236|Gammaproteobacteria,3XPH0@561|Escherichia 1236|Gammaproteobacteria C Catalyzes the reduction of soluble flavins by reduced pyridine nucleotides. Seems to reduce the complexed Fe(3 ) iron of siderophores to Fe(2 ), thus releasing it from the chelator fre GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006807,GO:0006950,GO:0006979,GO:0008047,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016645,GO:0016646,GO:0019538,GO:0030091,GO:0030234,GO:0042602,GO:0043085,GO:0043170,GO:0044093,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0050790,GO:0050896,GO:0052875,GO:0055114,GO:0065007,GO:0065009,GO:0071704,GO:0098772,GO:1901564 1.16.1.3,1.17.1.1,1.5.1.41 ko:K00523,ko:K05368,ko:K20256 ko00520,ko00740,ko00860,ko01100,ko02024,map00520,map00740,map00860,map01100,map02024 - R00097,R03391,R03392,R05705 RC00126,RC00220,RC00230 ko00000,ko00001,ko01000 - - iSF_1195.SF3920,iSFxv_1172.SFxv_4273,iS_1188.S3832 FAD_binding_6,Fer2,NAD_binding_1 k59_1502653_1 292415.Tbd_0437 4.16e-48 169.0 COG0477@1|root,COG2814@2|Bacteria,1MVSH@1224|Proteobacteria,2VITN@28216|Betaproteobacteria,1KRDC@119069|Hydrogenophilales 119069|Hydrogenophilales EGP Sugar (and other) transporter - - - - - - - - - - - - MFS_1,Sugar_tr k59_536085_1 1038859.AXAU01000015_gene935 2.48e-86 263.0 COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2UR9F@28211|Alphaproteobacteria 28211|Alphaproteobacteria S protein conserved in bacteria - - - - - - - - - - - - TctC k59_480838_1 994479.GL877878_gene295 3.7e-76 244.0 COG0154@1|root,COG0154@2|Bacteria,2GJK5@201174|Actinobacteria,4DXTM@85010|Pseudonocardiales 201174|Actinobacteria J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) gatA GO:0008150,GO:0040007 6.3.5.6,6.3.5.7 ko:K02433 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - Amidase k59_1389525_1 702113.PP1Y_AT4826 4.92e-11 59.3 2AMFW@1|root,31CBD@2|Bacteria,1NPT4@1224|Proteobacteria,2UMCJ@28211|Alphaproteobacteria,2K7Z7@204457|Sphingomonadales 204457|Sphingomonadales - - - - - - - - - - - - - - - k59_1389525_2 1096930.L284_10600 4.29e-68 207.0 COG1539@1|root,COG1539@2|Bacteria,1RKNS@1224|Proteobacteria,2UAD6@28211|Alphaproteobacteria,2K58X@204457|Sphingomonadales 204457|Sphingomonadales H dihydroneopterin aldolase - - 1.13.11.81,4.1.2.25,5.1.99.8 ko:K01633 ko00790,ko01100,map00790,map01100 M00126,M00840 R03504,R11037,R11073 RC00721,RC00943,RC01479,RC03333,RC03334 ko00000,ko00001,ko00002,ko01000 - - - FolB k59_1389525_3 983920.Y88_1828 1.53e-10 58.5 COG0219@1|root,COG0219@2|Bacteria,1RCY4@1224|Proteobacteria,2U78W@28211|Alphaproteobacteria,2K57A@204457|Sphingomonadales 204457|Sphingomonadales J Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide trmL - 2.1.1.207 ko:K03216 - - - - ko00000,ko01000,ko03016 - - - SpoU_methylase k59_1441446_1 1415778.JQMM01000001_gene1132 1.34e-106 326.0 COG4784@1|root,COG4784@2|Bacteria,1QTT7@1224|Proteobacteria,1RSQ1@1236|Gammaproteobacteria,1J4X0@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Zn-dependent protease - - - - - - - - - - - - Peptidase_M48 k59_1441446_2 1415778.JQMM01000001_gene1174 2.43e-14 68.9 COG0071@1|root,COG0071@2|Bacteria,1N7C7@1224|Proteobacteria,1S607@1236|Gammaproteobacteria,1J70E@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O Belongs to the small heat shock protein (HSP20) family - - - ko:K13993 ko04141,map04141 - - - ko00000,ko00001,ko03110 - - - HSP20 k59_1502664_1 1229909.NSED_09760 4.59e-77 237.0 COG0483@1|root,arCOG01349@2157|Archaea,41T8P@651137|Thaumarchaeota 651137|Thaumarchaeota G Inositol monophosphatase - - 3.1.3.25,3.1.3.7 ko:K01082,ko:K01092 ko00521,ko00562,ko00920,ko01100,ko01120,ko01130,ko04070,map00521,map00562,map00920,map01100,map01120,map01130,map04070 M00131 R00188,R00508,R01185,R01186,R01187 RC00078 ko00000,ko00001,ko00002,ko01000,ko03016 - - - Inositol_P k59_1502664_2 1229909.NSED_09765 1.36e-34 119.0 arCOG08813@1|root,arCOG08813@2157|Archaea,41T88@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_425340_1 436308.Nmar_0473 8.6e-11 58.5 arCOG07802@1|root,arCOG07802@2157|Archaea,41T6C@651137|Thaumarchaeota 651137|Thaumarchaeota S Pfam:DUF385 - - - - - - - - - - - - F420H2_quin_red k59_425340_2 1229909.NSED_02370 2.43e-123 355.0 arCOG08734@1|root,arCOG08734@2157|Archaea,41SP9@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_425340_3 436308.Nmar_0469 1.52e-52 169.0 arCOG10527@1|root,arCOG10527@2157|Archaea,41SPB@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_89927_1 1120983.KB894573_gene370 2.94e-17 81.6 COG1643@1|root,COG1643@2|Bacteria,1MUEQ@1224|Proteobacteria,2TRMJ@28211|Alphaproteobacteria,1JNPM@119043|Rhodobiaceae 28211|Alphaproteobacteria L Helicase associated domain (HA2) Add an annotation hrpB - 3.6.4.13 ko:K03579 - - - - ko00000,ko01000 - - - DEAD,HA2,Helicase_C,HrpB_C k59_372953_2 1122603.ATVI01000006_gene369 8.78e-79 262.0 COG0784@1|root,COG5000@1|root,COG5002@1|root,COG0784@2|Bacteria,COG5000@2|Bacteria,COG5002@2|Bacteria,1NC9X@1224|Proteobacteria,1T3U3@1236|Gammaproteobacteria,1XDBR@135614|Xanthomonadales 135614|Xanthomonadales T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA,Response_reg k59_597710_1 1051632.TPY_0530 5.64e-44 159.0 COG3328@1|root,COG3328@2|Bacteria,1TP4C@1239|Firmicutes,248UI@186801|Clostridia 186801|Clostridia L PFAM transposase, mutator - - - ko:K07493 - - - - ko00000 - - - Transposase_mut k59_1779080_2 1411685.U062_00900 7.07e-76 239.0 COG0707@1|root,COG0707@2|Bacteria,1MVIB@1224|Proteobacteria,1RMQ3@1236|Gammaproteobacteria,1J4FG@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) murG GO:0000270,GO:0003674,GO:0003824,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008194,GO:0008375,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016740,GO:0016757,GO:0016758,GO:0030203,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0050511,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 2.4.1.227 ko:K02563 ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112 - R05032,R05662 RC00005,RC00049 ko00000,ko00001,ko01000,ko01011 - GT28 iSFV_1184.SFV_0083,iSF_1195.SF0087,iSFxv_1172.SFxv_0091,iS_1188.S0089 Glyco_tran_28_C,Glyco_transf_28 k59_881333_1 1120999.JONM01000006_gene2384 2.54e-20 89.0 COG0192@1|root,COG0192@2|Bacteria,1MUFQ@1224|Proteobacteria,2VH7U@28216|Betaproteobacteria,2KPT2@206351|Neisseriales 206351|Neisseriales H Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme metK - 2.5.1.6 ko:K00789 ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230 M00034,M00035,M00368,M00609 R00177,R04771 RC00021,RC01211 ko00000,ko00001,ko00002,ko01000 - - - S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N k59_881333_2 404589.Anae109_0161 8e-77 243.0 COG0499@1|root,COG0499@2|Bacteria,1MUQ2@1224|Proteobacteria,42M83@68525|delta/epsilon subdivisions,2WIZE@28221|Deltaproteobacteria,2YXH5@29|Myxococcales 28221|Deltaproteobacteria H May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine ahcY GO:0000096,GO:0003674,GO:0003824,GO:0004013,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006534,GO:0006555,GO:0006575,GO:0006725,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009066,GO:0009069,GO:0009116,GO:0009119,GO:0009987,GO:0016787,GO:0016801,GO:0016802,GO:0017144,GO:0019752,GO:0033353,GO:0034641,GO:0042278,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046128,GO:0046439,GO:0046483,GO:0046498,GO:0046500,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564,GO:1901605,GO:1901657 3.3.1.1 ko:K01251 ko00270,ko01100,map00270,map01100 M00035 R00192,R04936 RC00056,RC00069,RC01161,RC01243 ko00000,ko00001,ko00002,ko01000,ko01009,ko04147 - - - AdoHcyase,AdoHcyase_NAD k59_763198_1 436308.Nmar_1416 1.78e-104 307.0 COG0020@1|root,arCOG01532@2157|Archaea,41S8J@651137|Thaumarchaeota 651137|Thaumarchaeota H Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids uppS - 2.5.1.89 ko:K15888 ko00900,map00900 - R09730 RC00279,RC02839 ko00000,ko00001,ko01000 - - - Prenyltransf k59_1668724_1 985054.JQEZ01000003_gene1013 8.65e-92 278.0 COG1622@1|root,COG1622@2|Bacteria,1MWHZ@1224|Proteobacteria,2U0IR@28211|Alphaproteobacteria,4NAIA@97050|Ruegeria 28211|Alphaproteobacteria C ubiquinol oxidase subunit cyoA - 1.10.3.10 ko:K02297 ko00190,ko01100,map00190,map01100 M00417 R11335 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.4.5 - - COX2,COX_ARM k59_480867_1 243159.AFE_0872 1.24e-39 150.0 COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,1S0BH@1236|Gammaproteobacteria,2NDH6@225057|Acidithiobacillales 225057|Acidithiobacillales O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner - - 3.4.21.53 ko:K01338 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - AAA,LON_substr_bdg,Lon_C k59_1726590_1 1122201.AUAZ01000042_gene1259 3.92e-18 81.6 COG1414@1|root,COG1414@2|Bacteria,1MXRJ@1224|Proteobacteria,1S3BI@1236|Gammaproteobacteria,46CQQ@72275|Alteromonadaceae 1236|Gammaproteobacteria K Bacterial transcriptional regulator - - - - - - - - - - - - HTH_IclR,IclR k59_1726590_2 626418.bglu_1g31960 3.09e-26 105.0 COG1960@1|root,COG1960@2|Bacteria,1MUBH@1224|Proteobacteria,2VHX0@28216|Betaproteobacteria,1K0SX@119060|Burkholderiaceae 28216|Betaproteobacteria C acyl-CoA dehydrogenase - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_1328685_1 1121022.ABENE_20270 3.1e-90 281.0 COG0446@1|root,COG0446@2|Bacteria,1Q0P8@1224|Proteobacteria,2U4CV@28211|Alphaproteobacteria 28211|Alphaproteobacteria C Tryptophan halogenase - - 1.14.19.9 ko:K14266 ko00404,ko01130,map00404,map01130 M00789,M00790 R09570 RC00949 ko00000,ko00001,ko00002,ko01000 - - - Trp_halogenase k59_1779089_1 1415778.JQMM01000001_gene605 9.94e-122 375.0 COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,1RNBG@1236|Gammaproteobacteria,1J4YE@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity polA GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008408,GO:0008409,GO:0009058,GO:0009059,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901362,GO:1901363,GO:1901576 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1 k59_144329_1 946077.W5A_05768 5.14e-38 137.0 COG1914@1|root,COG1914@2|Bacteria,4NEG8@976|Bacteroidetes,1HYMN@117743|Flavobacteriia 976|Bacteroidetes P Mn2 and Fe2 transporters of the NRAMP family - - - - - - - - - - - - Nramp k59_144329_2 1121912.AUHD01000001_gene2367 6.2e-72 220.0 COG1595@1|root,COG1595@2|Bacteria,4NIRG@976|Bacteroidetes,1I19Q@117743|Flavobacteriia 976|Bacteroidetes K Belongs to the sigma-70 factor family. ECF subfamily - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 k59_710929_1 247634.GPB2148_153 5.25e-15 72.8 COG3767@1|root,COG3767@2|Bacteria,1N9HK@1224|Proteobacteria,1SD4Q@1236|Gammaproteobacteria,1J6WQ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_710929_2 1279019.ARQK01000061_gene1805 7.78e-13 67.4 COG3220@1|root,COG3220@2|Bacteria,1MURE@1224|Proteobacteria,1RQ9H@1236|Gammaproteobacteria,1WWJ1@135613|Chromatiales 135613|Chromatiales S Belongs to the UPF0276 family - - - ko:K09930 - - - - ko00000 - - - DUF692 k59_1389584_1 765952.PUV_12860 5.69e-63 207.0 COG2230@1|root,COG2230@2|Bacteria 2|Bacteria M cyclopropane-fatty-acyl-phospholipid synthase cfa - 2.1.1.317,2.1.1.79 ko:K00574,ko:K20238 - - - - ko00000,ko01000 - - - CMAS k59_881365_1 1121035.AUCH01000008_gene1001 8.77e-69 222.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2VKD8@28216|Betaproteobacteria,2KV57@206389|Rhodocyclales 206389|Rhodocyclales T COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains - - - - - - - - - - - - HTH_8,Response_reg,Sigma54_activ_2 k59_1502717_1 1122137.AQXF01000006_gene672 8.61e-70 234.0 COG0308@1|root,COG0308@2|Bacteria,1MUCI@1224|Proteobacteria,2TRUM@28211|Alphaproteobacteria 28211|Alphaproteobacteria E aminopeptidase N pepN GO:0003674,GO:0003824,GO:0004177,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008235,GO:0008237,GO:0008238,GO:0008270,GO:0016020,GO:0016787,GO:0019538,GO:0033218,GO:0042277,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0044238,GO:0044424,GO:0044464,GO:0046872,GO:0046914,GO:0070006,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564 3.4.11.2 ko:K01256 ko00480,ko01100,map00480,map01100 - R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 - - - DUF3458,DUF3458_C,Peptidase_M1 k59_1726609_1 314287.GB2207_09656 1.06e-48 177.0 COG1629@1|root,COG1629@2|Bacteria,1MX4K@1224|Proteobacteria,1RP6B@1236|Gammaproteobacteria,1J4RA@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P COG1629 Outer membrane receptor proteins, mostly Fe transport - - - - - - - - - - - - Plug,TonB_dep_Rec k59_1502720_1 861299.J421_2612 1e-71 227.0 COG1063@1|root,COG1063@2|Bacteria,1ZSWB@142182|Gemmatimonadetes 142182|Gemmatimonadetes C Zinc-binding dehydrogenase - - 1.1.1.103 ko:K00060 ko00260,map00260 - R01465 RC00525 ko00000,ko00001,ko01000 - - - ADH_N,ADH_zinc_N k59_1161341_1 1229909.NSED_02160 4.91e-86 254.0 arCOG08664@1|root,arCOG08664@2157|Archaea,41SKM@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1726617_1 981223.AIED01000019_gene603 1.61e-41 153.0 COG1463@1|root,COG3008@1|root,COG1463@2|Bacteria,COG3008@2|Bacteria,1MU1T@1224|Proteobacteria,1RN89@1236|Gammaproteobacteria,3NKNI@468|Moraxellaceae 1236|Gammaproteobacteria Q MlaD protein pqiB - - ko:K06192 - - - - ko00000 - - - MlaD k59_1614027_1 1117647.M5M_12057 2.33e-21 100.0 COG1729@1|root,COG1729@2|Bacteria,1MX82@1224|Proteobacteria,1T32S@1236|Gammaproteobacteria 1236|Gammaproteobacteria O protein conserved in bacteria - - - - - - - - - - - - TPR_16,TPR_6,TPR_8 k59_597770_1 377629.TERTU_0557 1.15e-89 282.0 COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,1RMNZ@1236|Gammaproteobacteria,2PMPW@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria I Acetyl-coenzyme A synthetase N-terminus acsA - 6.2.1.1 ko:K01895 ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200 M00357 R00235,R00236,R00316,R00926,R01354 RC00004,RC00012,RC00043,RC00070,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000,ko01004 - - - ACAS_N,AMP-binding,AMP-binding_C k59_1103072_1 1123269.NX02_17600 1.23e-110 331.0 COG2124@1|root,COG2124@2|Bacteria,1MY5H@1224|Proteobacteria,2TR6X@28211|Alphaproteobacteria,2K3RN@204457|Sphingomonadales 204457|Sphingomonadales C cytochrome P450 - - - - - - - - - - - - p450 k59_1103072_2 279238.Saro_3831 1.12e-39 141.0 COG1609@1|root,COG1609@2|Bacteria,1MUEP@1224|Proteobacteria,2U7WF@28211|Alphaproteobacteria,2K2KB@204457|Sphingomonadales 204457|Sphingomonadales K helix_turn _helix lactose operon repressor - - - ko:K06145 - - - - ko00000,ko03000 - - - LacI,Peripla_BP_3 k59_536146_1 1122612.AUBA01000002_gene1696 1.67e-102 301.0 2ED7G@1|root,31A10@2|Bacteria,1NV3Q@1224|Proteobacteria,2URPA@28211|Alphaproteobacteria,2KA1R@204457|Sphingomonadales 204457|Sphingomonadales S SnoaL-like domain - - - - - - - - - - - - SnoaL_4 k59_480904_1 1192759.AKIB01000026_gene2165 1.22e-57 187.0 COG0625@1|root,COG0625@2|Bacteria,1NR5A@1224|Proteobacteria,2UQVF@28211|Alphaproteobacteria,2K9J6@204457|Sphingomonadales 204457|Sphingomonadales O Glutathione S-transferase, C-terminal domain - - - - - - - - - - - - GST_C k59_1328724_1 331869.BAL199_20400 9.84e-55 189.0 COG1960@1|root,COG1960@2|Bacteria,1MU20@1224|Proteobacteria,2TQJS@28211|Alphaproteobacteria,4BP9N@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria I Acetyl-CoA dehydrogenase C-terminal like - - - ko:K20035 ko00920,map00920 - R11130 RC03363 ko00000,ko00001,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_C,Acyl-CoA_dh_M,Acyl-CoA_dh_N,AcylCoA_DH_N k59_536154_2 1095769.CAHF01000011_gene2298 2.89e-12 68.9 COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,2VJ9G@28216|Betaproteobacteria,472ZS@75682|Oxalobacteraceae 28216|Betaproteobacteria O Belongs to the peptidase S1C family - - - - - - - - - - - - PDZ_2,Trypsin_2 k59_425416_1 1137799.GZ78_09065 2.89e-26 110.0 COG0750@1|root,COG0750@2|Bacteria,1MU91@1224|Proteobacteria,1RMIX@1236|Gammaproteobacteria,1XH5P@135619|Oceanospirillales 135619|Oceanospirillales M zinc metalloprotease rseP - - ko:K11749 ko02024,ko04112,map02024,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - PDZ,PDZ_2,Peptidase_M50 k59_710985_1 309798.COPRO5265_1250 2.25e-12 67.8 COG2256@1|root,COG2256@2|Bacteria,1TPVV@1239|Firmicutes,247X2@186801|Clostridia,42FF6@68295|Thermoanaerobacterales 186801|Clostridia L AAA ATPase, central domain protein rarA - - ko:K07478 - - - - ko00000 - - - AAA,AAA_assoc_2,MgsA_C,RuvB_N k59_710985_2 314278.NB231_10058 7.57e-24 98.6 COG0788@1|root,COG0788@2|Bacteria,1MVCF@1224|Proteobacteria,1RN6Q@1236|Gammaproteobacteria,1WXFH@135613|Chromatiales 135613|Chromatiales F Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4) purU - 3.5.1.10 ko:K01433 ko00630,ko00670,map00630,map00670 - R00944 RC00026,RC00111 ko00000,ko00001,ko01000 - - - ACT,Formyl_trans_N k59_1502766_1 1394178.AWOO02000072_gene443 1.53e-39 140.0 COG1024@1|root,COG1024@2|Bacteria,2GKC4@201174|Actinobacteria 201174|Actinobacteria I Belongs to the enoyl-CoA hydratase isomerase family - - - - - - - - - - - - ECH_1 k59_1161389_1 1000565.METUNv1_00653 3.46e-39 142.0 COG1597@1|root,COG1597@2|Bacteria,1MY37@1224|Proteobacteria,2VM11@28216|Betaproteobacteria,2KW2P@206389|Rhodocyclales 206389|Rhodocyclales I Diacylglycerol kinase catalytic domain - - - - - - - - - - - - DAGK_cat k59_988909_1 1120948.KB903229_gene5361 1.11e-09 60.1 COG1136@1|root,COG1136@2|Bacteria,2GK3I@201174|Actinobacteria,4DXK6@85010|Pseudonocardiales 201174|Actinobacteria V ATPases associated with a variety of cellular activities - - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_988909_2 1303518.CCALI_01460 2.53e-05 49.3 COG0845@1|root,COG0845@2|Bacteria 2|Bacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - ko:K02005,ko:K13888 - M00709 - - ko00000,ko00002,ko02000 8.A.1 - - Biotin_lipoyl_2,HlyD_D23 k59_1161391_1 498761.HM1_2439 1.65e-40 147.0 COG2264@1|root,COG2264@2|Bacteria,1TPKI@1239|Firmicutes,247VY@186801|Clostridia 186801|Clostridia J Ribosomal protein L11 methyltransferase prmA - - ko:K02687 - - - - ko00000,ko01000,ko03009 - - - PrmA k59_1389648_3 395494.Galf_1617 1.15e-71 246.0 COG0492@1|root,COG0664@1|root,COG1142@1|root,COG0492@2|Bacteria,COG0664@2|Bacteria,COG1142@2|Bacteria,1PPH1@1224|Proteobacteria,2W9GU@28216|Betaproteobacteria,44WKA@713636|Nitrosomonadales 28216|Betaproteobacteria C FAD-dependent pyridine nucleotide-disulphide oxidoreductase - - - - - - - - - - - - Pyr_redox_3 k59_821065_1 158500.BV97_02446 1.41e-80 249.0 COG0240@1|root,COG0240@2|Bacteria,1MUU3@1224|Proteobacteria,2TT75@28211|Alphaproteobacteria,2K0GB@204457|Sphingomonadales 204457|Sphingomonadales I Glycerol-3-phosphate dehydrogenase gpsA - 1.1.1.94 ko:K00057 ko00564,ko01110,map00564,map01110 - R00842,R00844 RC00029 ko00000,ko00001,ko01000 - - - NAD_Gly3P_dh_C,NAD_Gly3P_dh_N k59_90011_1 1125863.JAFN01000001_gene3206 8.06e-37 140.0 COG2159@1|root,COG2159@2|Bacteria,1QZ3W@1224|Proteobacteria,42PKB@68525|delta/epsilon subdivisions,2WM59@28221|Deltaproteobacteria 28221|Deltaproteobacteria L PFAM transposase, IS4 family protein - - - - - - - - - - - - DDE_Tnp_1_4 k59_33453_1 2850.Phatr43450 4.37e-15 79.3 2CZK8@1|root,2SARX@2759|Eukaryota 2759|Eukaryota - - - - - - - - - - - - - - DUF4886 k59_33453_2 40571.JOEA01000022_gene6985 0.000291 49.3 COG0596@1|root,COG0596@2|Bacteria,2I38Y@201174|Actinobacteria,4EFDC@85010|Pseudonocardiales 201174|Actinobacteria S Serine aminopeptidase, S33 - - - - - - - - - - - - Abhydrolase_1,Abhydrolase_6 k59_763275_1 493475.GARC_0486 4.08e-25 105.0 COG4805@1|root,COG4805@2|Bacteria,1MZDR@1224|Proteobacteria,1RZK8@1236|Gammaproteobacteria,465YN@72275|Alteromonadaceae 1236|Gammaproteobacteria S Protein conserved in bacteria - - - - - - - - - - - - - k59_881461_1 643867.Ftrac_0807 1.59e-47 173.0 COG0466@1|root,COG0466@2|Bacteria,4NE1G@976|Bacteroidetes,47M84@768503|Cytophagia 976|Bacteroidetes O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner lon - 3.4.21.53 ko:K01338 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - AAA,LON_substr_bdg,Lon_C k59_258389_1 649831.L083_5308 9.42e-66 207.0 COG0388@1|root,COG0388@2|Bacteria,2GKRJ@201174|Actinobacteria,4D96X@85008|Micromonosporales 201174|Actinobacteria S Carbon-nitrogen hydrolase - - 3.5.1.6 ko:K01431 ko00240,ko00410,ko00770,ko00983,ko01100,map00240,map00410,map00770,map00983,map01100 M00046 R00905,R04666,R08228 RC00096 ko00000,ko00001,ko00002,ko01000 - - - CN_hydrolase k59_1614082_1 883126.HMPREF9710_00782 1.54e-56 187.0 COG3039@1|root,COG3039@2|Bacteria,1MVDK@1224|Proteobacteria,2VI1H@28216|Betaproteobacteria 28216|Betaproteobacteria L PFAM transposase, IS4 family protein - - - ko:K07481 - - - - ko00000 - - - DDE_Tnp_1,DUF772 k59_712239_2 318167.Sfri_0030 1.49e-126 367.0 COG0408@1|root,COG0408@2|Bacteria,1MWMF@1224|Proteobacteria,1RMM8@1236|Gammaproteobacteria,2QA4X@267890|Shewanellaceae 1236|Gammaproteobacteria H Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX hemF GO:0003674,GO:0003824,GO:0004109,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016491,GO:0016627,GO:0016634,GO:0018130,GO:0019438,GO:0030145,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0046872,GO:0046906,GO:0046914,GO:0046983,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 1.3.3.3 ko:K00228 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R03220 RC00884 ko00000,ko00001,ko00002,ko01000 - - iAF1260.b2436,iBWG_1329.BWG_2198,iECDH10B_1368.ECDH10B_2601,iECDH1ME8569_1439.ECDH1ME8569_2370,iETEC_1333.ETEC_2549,iEcDH1_1363.EcDH1_1225,iEcHS_1320.EcHS_A2573,iEcolC_1368.EcolC_1243,iJO1366.b2436,iJR904.b2436,iY75_1357.Y75_RS12760 Coprogen_oxidas k59_1503995_1 1111728.ATYS01000031_gene103 1.26e-92 288.0 COG0477@1|root,COG2814@2|Bacteria,1MUZ8@1224|Proteobacteria,1T1NH@1236|Gammaproteobacteria 1236|Gammaproteobacteria EGP Major facilitator superfamily ampG GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008324,GO:0015075,GO:0015077,GO:0015078,GO:0015291,GO:0015293,GO:0015294,GO:0015295,GO:0015318,GO:0015672,GO:0015835,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0022890,GO:0031224,GO:0031226,GO:0034220,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:1901264,GO:1902600 - ko:K08218 ko01501,map01501 M00628 - - ko00000,ko00001,ko00002,ko02000 2.A.1.25 - - MFS_1 k59_882672_2 1112209.AHVZ01000011_gene136 1.17e-06 57.4 COG2267@1|root,COG2267@2|Bacteria,1REM6@1224|Proteobacteria,1S1F7@1236|Gammaproteobacteria,3NIFG@468|Moraxellaceae 1236|Gammaproteobacteria I Serine aminopeptidase, S33 - - - - - - - - - - - - Abhydrolase_1 k59_882672_3 1265505.ATUG01000002_gene2404 8.88e-111 325.0 COG2013@1|root,COG2013@2|Bacteria,1NBBE@1224|Proteobacteria,42N2E@68525|delta/epsilon subdivisions,2WJFV@28221|Deltaproteobacteria,2MIP6@213118|Desulfobacterales 28221|Deltaproteobacteria S Mitochondrial biogenesis AIM24 - - - - - - - - - - - - AIM24,DUF4339 k59_1272799_1 1539298.JO41_03670 1.07e-08 62.8 COG1033@1|root,COG1033@2|Bacteria,2J636@203691|Spirochaetes 203691|Spirochaetes S COGs COG1033 exporter of the RND superfamily protein - - - ko:K07003 - - - - ko00000 - - - MMPL k59_1727539_1 1089551.KE386572_gene3257 1.73e-10 60.1 COG3909@1|root,COG3909@2|Bacteria,1N6Z5@1224|Proteobacteria,2UFS6@28211|Alphaproteobacteria 28211|Alphaproteobacteria C Cytochrome C556 cycF - - - - - - - - - - - Cytochrom_C_2 k59_1727539_2 1179778.PMM47T1_08501 2.94e-38 140.0 COG2010@1|root,COG2010@2|Bacteria,1MV6D@1224|Proteobacteria,1RMYF@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Cytochrome c - - - - - - - - - - - - Cytochrom_C,Cytochrome_CBB3 k59_882681_1 1415778.JQMM01000001_gene1814 3.27e-144 419.0 COG0008@1|root,COG0008@2|Bacteria,1MUCR@1224|Proteobacteria,1RN3R@1236|Gammaproteobacteria,1J547@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) gltX GO:0003674,GO:0003824,GO:0004812,GO:0004818,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006424,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.17 ko:K01885 ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120 M00121,M00359,M00360 R05578 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016 - - iEC042_1314.EC042_2616 tRNA-synt_1c k59_1051447_1 1122137.AQXF01000003_gene1963 2.05e-156 463.0 COG4772@1|root,COG4772@2|Bacteria,1NTC4@1224|Proteobacteria,2U3CZ@28211|Alphaproteobacteria 28211|Alphaproteobacteria P TonB dependent receptor - - - - - - - - - - - - Plug,TonB_dep_Rec k59_989784_1 1454004.AW11_03085 2.25e-57 197.0 28HMZ@1|root,2Z7WD@2|Bacteria,1MU3Q@1224|Proteobacteria 1224|Proteobacteria S Protein of unknown function (DUF3604) - - - - - - - - - - - - DUF3604 k59_599136_1 765910.MARPU_05390 2.99e-21 92.4 COG4191@1|root,COG4191@2|Bacteria,1MU55@1224|Proteobacteria,1RQ5N@1236|Gammaproteobacteria,1WWAJ@135613|Chromatiales 135613|Chromatiales T Histidine kinase - - - - - - - - - - - - GAF_2,HATPase_c k59_1561220_1 321846.PS417_04105 6.87e-16 80.1 COG4178@1|root,COG4178@2|Bacteria,1MW09@1224|Proteobacteria,1RPQA@1236|Gammaproteobacteria 1236|Gammaproteobacteria S (ABC) transporter yddA - - ko:K02471 ko02010,map02010 - - - ko00000,ko00001,ko02000 3.A.1.203.11,3.A.1.203.4 - - ABC_membrane_2,ABC_tran k59_599144_1 626887.J057_04736 2.09e-51 166.0 COG0251@1|root,COG0251@2|Bacteria,1MZ3J@1224|Proteobacteria,1S5XS@1236|Gammaproteobacteria,4679E@72275|Alteromonadaceae 1236|Gammaproteobacteria J translation initiation inhibitor, yjgF family tdcF - - - - - - - - - - - Ribonuc_L-PSP k59_1329656_1 1415778.JQMM01000001_gene1210 7.23e-91 276.0 COG0142@1|root,COG0142@2|Bacteria,1MUK6@1224|Proteobacteria,1RPR7@1236|Gammaproteobacteria,1J4PY@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Belongs to the FPP GGPP synthase family ispB GO:0003674,GO:0003824,GO:0004659,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006066,GO:0006629,GO:0006720,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009108,GO:0009987,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0042180,GO:0042181,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901615,GO:1901617,GO:1901661,GO:1901663 2.5.1.90 ko:K02523 ko00900,ko01110,map00900,map01110 - R09248 RC00279 ko00000,ko00001,ko01000,ko01006 - - iYL1228.KPN_03597,ic_1306.c3945 polyprenyl_synt k59_882698_1 1121374.KB891576_gene656 1.35e-82 272.0 COG5276@1|root,COG5276@2|Bacteria,1R66X@1224|Proteobacteria,1S05Q@1236|Gammaproteobacteria 1236|Gammaproteobacteria S LVIVD repeat - - - - - - - - - - - - LVIVD k59_1561229_1 1279017.AQYJ01000025_gene449 1.07e-34 122.0 COG1225@1|root,COG1225@2|Bacteria 2|Bacteria O peroxiredoxin activity - - - - - - - - - - - - DUF4369,Redoxin,Thioredoxin_8,UnbV_ASPIC,VCBS k59_1785192_1 498211.CJA_0461 1.02e-77 244.0 COG0263@1|root,COG0263@2|Bacteria,1MUBG@1224|Proteobacteria,1RM7X@1236|Gammaproteobacteria,1FGZA@10|Cellvibrio 1236|Gammaproteobacteria E Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate proB GO:0000287,GO:0003674,GO:0003824,GO:0004349,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016597,GO:0016740,GO:0016772,GO:0016774,GO:0017144,GO:0018130,GO:0019202,GO:0019752,GO:0031406,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046872,GO:0055129,GO:0071704,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1901973 2.7.2.11 ko:K00931 ko00330,ko00332,ko01100,ko01130,ko01230,map00330,map00332,map01100,map01130,map01230 M00015 R00239 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase,PUA k59_324162_1 290512.Paes_0437 4.84e-76 238.0 COG0543@1|root,COG0543@2|Bacteria,1FDJ4@1090|Chlorobi 1090|Chlorobi C PFAM oxidoreductase FAD NAD(P)-binding domain protein - - 1.18.1.2,1.19.1.1 ko:K00528 - - R10159 - ko00000,ko01000 - - - DHODB_Fe-S_bind,NAD_binding_1 k59_1733335_1 1121904.ARBP01000008_gene3227 1.43e-39 153.0 COG2885@1|root,COG2885@2|Bacteria,4P236@976|Bacteroidetes 976|Bacteroidetes M OmpA family - - - - - - - - - - - - OmpA k59_41037_1 272568.GDI3670 3.39e-49 182.0 COG0234@1|root,COG0234@2|Bacteria,1NJKP@1224|Proteobacteria,2UM25@28211|Alphaproteobacteria 28211|Alphaproteobacteria O Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter - - - ko:K04078 - - - - ko00000,ko03029,ko03110 - - - - k59_41037_3 157783.LK03_15020 1.94e-36 139.0 COG4626@1|root,COG4626@2|Bacteria,1R2FH@1224|Proteobacteria,1RN1F@1236|Gammaproteobacteria 1236|Gammaproteobacteria F Terminase - - - - - - - - - - - - - k59_487657_1 1283300.ATXB01000001_gene480 2.18e-99 311.0 COG0438@1|root,COG0438@2|Bacteria,1MWVX@1224|Proteobacteria,1RSR5@1236|Gammaproteobacteria,1XDS7@135618|Methylococcales 1224|Proteobacteria M Sucrose phosphate synthase, sucrose phosphatase-like mfpsA GO:0003674,GO:0003824,GO:0005975,GO:0005984,GO:0008150,GO:0008152,GO:0009058,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0034637,GO:0044237,GO:0044238,GO:0044249,GO:0044262,GO:0046351,GO:0071704,GO:1901576 2.4.1.246 ko:K13058 - - R08947 RC00005,RC00028 ko00000,ko01000 - - - Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1 k59_1785197_1 1229909.NSED_01405 1.69e-120 354.0 COG0750@1|root,arCOG00609@2157|Archaea,41S8V@651137|Thaumarchaeota 651137|Thaumarchaeota M Peptidase family M50 - - - - - - - - - - - - Peptidase_M50 k59_605867_1 234267.Acid_6116 2.47e-50 175.0 COG0154@1|root,COG0154@2|Bacteria 2|Bacteria J amidase activity gatA - 3.5.1.4,3.5.1.84,6.3.5.6,6.3.5.7 ko:K01426,ko:K02433,ko:K19837 ko00330,ko00360,ko00380,ko00627,ko00643,ko00791,ko00970,ko01100,ko01120,map00330,map00360,map00380,map00627,map00643,map00791,map00970,map01100,map01120 - R02540,R03096,R03180,R03905,R03909,R04212,R05551,R05563,R05590 RC00010,RC00100,RC00950,RC01025,RC01287 ko00000,ko00001,ko01000,ko03029 - - - Amidase k59_1169211_1 190650.CC_2218 5.06e-11 62.8 COG1434@1|root,COG1434@2|Bacteria,1RHMV@1224|Proteobacteria,2U957@28211|Alphaproteobacteria,2KGI6@204458|Caulobacterales 204458|Caulobacterales S DUF218 domain - - - - - - - - - - - - DUF218 k59_1448695_1 1286093.C266_23983 2.38e-29 117.0 COG2267@1|root,COG2267@2|Bacteria,1P7JV@1224|Proteobacteria,2VR0X@28216|Betaproteobacteria,1K7Z4@119060|Burkholderiaceae 28216|Betaproteobacteria I Serine aminopeptidase, S33 - - - - - - - - - - - - Abhydrolase_1,Abhydrolase_4,Abhydrolase_6 k59_1448695_2 367336.OM2255_07105 8.62e-75 233.0 COG1028@1|root,COG1028@2|Bacteria,1RBGC@1224|Proteobacteria,2U6FD@28211|Alphaproteobacteria 28211|Alphaproteobacteria IQ Enoyl-(Acyl carrier protein) reductase - - - - - - - - - - - - adh_short_C2 k59_657773_1 1394178.AWOO02000034_gene8341 1e-64 214.0 COG2141@1|root,COG3255@1|root,COG2141@2|Bacteria,COG3255@2|Bacteria,2GKP1@201174|Actinobacteria,4EHH5@85012|Streptosporangiales 201174|Actinobacteria C Luciferase-like monooxygenase - - - - - - - - - - - - Bac_luciferase,SCP2 k59_1109899_1 1037409.BJ6T_16580 1.54e-105 317.0 COG4948@1|root,COG4948@2|Bacteria,1MYZE@1224|Proteobacteria,2TU3A@28211|Alphaproteobacteria,3JW29@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria M Mandelate racemase / muconate lactonizing enzyme, C-terminal domain MA20_06335 - 4.2.1.156,4.2.1.42,5.1.2.2 ko:K01781,ko:K20023 ko00053,ko00627,ko01120,map00053,map00627,map01120 - R03791,R04161,R05608 RC00543,RC00998 ko00000,ko00001,ko01000 - - - MR_MLE_C,MR_MLE_N k59_1225225_1 1120970.AUBZ01000019_gene3563 1.13e-68 223.0 COG0715@1|root,COG0715@2|Bacteria,1MWDN@1224|Proteobacteria,1RPUP@1236|Gammaproteobacteria,465AR@72275|Alteromonadaceae 1236|Gammaproteobacteria P COG0715 ABC-type nitrate sulfonate bicarbonate transport systems, periplasmic components nrtC - - ko:K15576 ko00910,ko02010,map00910,map02010 M00438 - - ko00000,ko00001,ko00002,ko02000 3.A.1.16.1,3.A.1.16.2 - - NMT1_2 k59_1448698_1 1229909.NSED_08995 2.98e-118 341.0 COG1394@1|root,arCOG04101@2157|Archaea,41T0N@651137|Thaumarchaeota 651137|Thaumarchaeota C Produces ATP from ADP in the presence of a proton gradient across the membrane atpD - - ko:K02120 ko00190,ko01100,map00190,map01100 M00159 - - ko00000,ko00001,ko00002 3.A.2.2,3.A.2.3 - - ATP-synt_D k59_889198_2 1229909.NSED_06005 7.95e-24 104.0 arCOG03042@1|root,arCOG03042@2157|Archaea 2157|Archaea KLT PFAM Tetratricopeptide repeat - - - - - - - - - - - - TPR_1,TPR_16,TPR_2,TPR_8 k59_1109904_1 1089552.KI911559_gene1700 2.01e-32 121.0 COG4977@1|root,COG4977@2|Bacteria,1MUDK@1224|Proteobacteria,2TS7I@28211|Alphaproteobacteria,2JPZ7@204441|Rhodospirillales 204441|Rhodospirillales K helix_turn_helix, arabinose operon control protein - - - - - - - - - - - - DJ-1_PfpI,HTH_18 k59_1109904_2 1121935.AQXX01000108_gene430 3.24e-53 179.0 COG0665@1|root,COG0665@2|Bacteria,1MVIZ@1224|Proteobacteria,1RQ50@1236|Gammaproteobacteria,1XIS7@135619|Oceanospirillales 135619|Oceanospirillales E D-amino acid dehydrogenase dadA - 1.4.5.1 ko:K00285 ko00360,map00360 - R01374,R09493 RC00006,RC00025 ko00000,ko00001,ko01000 - - - DAO k59_324184_1 313595.P700755_003811 3.85e-28 117.0 COG1538@1|root,COG2984@1|root,COG1538@2|Bacteria,COG2984@2|Bacteria,4NHGK@976|Bacteroidetes,1HX6D@117743|Flavobacteriia 976|Bacteroidetes MU Outer membrane efflux protein - - - - - - - - - - - - ABC_sub_bind,OEP k59_1169242_1 330214.NIDE1309 4.11e-118 348.0 COG0050@1|root,COG0050@2|Bacteria,3J0DG@40117|Nitrospirae 40117|Nitrospirae J This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis - - - ko:K02358 - - - - ko00000,ko03012,ko03029,ko04147 - - - GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3 k59_1225251_1 690850.Desaf_1814 1.33e-44 157.0 COG0491@1|root,COG0607@1|root,COG0491@2|Bacteria,COG0607@2|Bacteria,1MUDN@1224|Proteobacteria,42N3H@68525|delta/epsilon subdivisions,2WJSC@28221|Deltaproteobacteria,2MA27@213115|Desulfovibrionales 28221|Deltaproteobacteria P Rhodanese domain protein - - - - - - - - - - - - Lactamase_B,Rhodanese k59_889223_1 377629.TERTU_3939 3.62e-27 100.0 2AIDE@1|root,318UT@2|Bacteria,1QJ80@1224|Proteobacteria,1TH62@1236|Gammaproteobacteria,2PP13@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria S Domain of unknown function (DUF4266) - - - - - - - - - - - - DUF4266 k59_889223_2 225937.HP15_2144 2.16e-31 115.0 COG0526@1|root,COG0526@2|Bacteria,1MZ36@1224|Proteobacteria,1S8UU@1236|Gammaproteobacteria,4677J@72275|Alteromonadaceae 1236|Gammaproteobacteria CO Thioredoxin-like resA - - - - - - - - - - - AhpC-TSA,Redoxin k59_1785229_1 748247.AZKH_3810 1.44e-15 74.7 COG2022@1|root,COG2022@2|Bacteria,1N0N5@1224|Proteobacteria,2VJ8T@28216|Betaproteobacteria,2KURE@206389|Rhodocyclales 206389|Rhodocyclales H Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S - - 2.8.1.10 ko:K03149 ko00730,ko01100,map00730,map01100 - R10247 RC03096,RC03097,RC03461 ko00000,ko00001,ko01000 - - - ThiG k59_1785229_2 1485544.JQKP01000002_gene1605 1.74e-25 95.9 COG2104@1|root,COG2104@2|Bacteria,1NG8E@1224|Proteobacteria,2WARD@28216|Betaproteobacteria,44W4B@713636|Nitrosomonadales 28216|Betaproteobacteria H ThiS family - - - ko:K03154 ko04122,map04122 - - - ko00000,ko00001 - - - ThiS k59_657813_1 1122137.AQXF01000006_gene689 5.81e-32 117.0 COG2063@1|root,COG2063@2|Bacteria,1RDEY@1224|Proteobacteria,2TRHN@28211|Alphaproteobacteria 28211|Alphaproteobacteria N Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation flgH - - ko:K02393 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - FlgH k59_657813_2 555793.WSK_3152 1.33e-39 134.0 COG1734@1|root,COG1734@2|Bacteria,1RD08@1224|Proteobacteria,2U74V@28211|Alphaproteobacteria,2K4GE@204457|Sphingomonadales 204457|Sphingomonadales T Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters dksA - - ko:K06204 ko02026,map02026 - - - ko00000,ko00001,ko03000,ko03009,ko03021 - - - zf-dskA_traR k59_1225262_1 702113.PP1Y_AT6250 7.73e-108 335.0 COG3127@1|root,COG3127@2|Bacteria,1MU9R@1224|Proteobacteria,2TS8V@28211|Alphaproteobacteria,2K03T@204457|Sphingomonadales 204457|Sphingomonadales Q ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_1733382_1 377629.TERTU_0029 1.91e-39 149.0 COG5617@1|root,COG5617@2|Bacteria,1RJY5@1224|Proteobacteria,1SE0V@1236|Gammaproteobacteria,2PPHT@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria S 6-pyruvoyl-tetrahydropterin synthase related domain; membrane protein - - - - - - - - - - - - PTPS_related k59_1335344_1 1485544.JQKP01000001_gene906 2.45e-53 179.0 COG0232@1|root,COG0232@2|Bacteria,1MVQ2@1224|Proteobacteria,2VI7B@28216|Betaproteobacteria,44UZZ@713636|Nitrosomonadales 28216|Betaproteobacteria F Belongs to the dGTPase family. Type 2 subfamily dgt - 3.1.5.1 ko:K01129 ko00230,map00230 - R01856 RC00017 ko00000,ko00001,ko01000 - - - HD,HD_assoc k59_1225270_2 234267.Acid_7102 8.53e-40 157.0 COG1073@1|root,COG1073@2|Bacteria,3Y6D7@57723|Acidobacteria 57723|Acidobacteria S Acetyl xylan esterase (AXE1) - - - - - - - - - - - - AXE1 k59_151154_2 1410620.SHLA_4c002110 1.98e-43 151.0 COG0237@1|root,COG0237@2|Bacteria,1NEFS@1224|Proteobacteria,2UIWS@28211|Alphaproteobacteria,4BKKU@82115|Rhizobiaceae 28211|Alphaproteobacteria H dephospho-CoA kinase activity - - - - - - - - - - - - - k59_605938_1 1117647.M5M_13630 2.85e-92 287.0 COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,1RMBS@1236|Gammaproteobacteria,1J4CS@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria NU COG2804 Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB gspE - - ko:K02454 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - T2SSE,T2SSE_N k59_1733384_1 316407.85676426 5.95e-139 398.0 COG1063@1|root,COG1063@2|Bacteria,1MV9A@1224|Proteobacteria,1RMNY@1236|Gammaproteobacteria,3XPEF@561|Escherichia 1236|Gammaproteobacteria E Catalyzes the NAD( )-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate tdh GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006563,GO:0006564,GO:0006566,GO:0006567,GO:0006807,GO:0008150,GO:0008152,GO:0008198,GO:0008270,GO:0008652,GO:0008743,GO:0009056,GO:0009058,GO:0009063,GO:0009066,GO:0009068,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016054,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0030145,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046395,GO:0046870,GO:0046872,GO:0046914,GO:0055114,GO:0071704,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1901607 1.1.1.103 ko:K00060 ko00260,map00260 - R01465 RC00525 ko00000,ko00001,ko01000 - - iEC042_1314.EC042_3926,iECUMN_1333.ECUMN_4133,iPC815.YPO0060 ADH_N,ADH_zinc_N k59_324216_1 1033802.SSPSH_002593 9.68e-65 217.0 COG3158@1|root,COG3158@2|Bacteria,1MUVH@1224|Proteobacteria,1RPM6@1236|Gammaproteobacteria 1236|Gammaproteobacteria P transport of potassium into the cell kup GO:0003674,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015318,GO:0015672,GO:0016020,GO:0022857,GO:0022890,GO:0030001,GO:0034220,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0071804,GO:0071805,GO:0098655,GO:0098660,GO:0098662 - ko:K03549 - - - - ko00000,ko02000 2.A.72 - - K_trans k59_1397404_1 1415778.JQMM01000001_gene1918 7.14e-93 285.0 COG1726@1|root,COG1726@2|Bacteria,1MU36@1224|Proteobacteria,1RPU1@1236|Gammaproteobacteria,1J4N5@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol nqrA GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0006810,GO:0006811,GO:0006812,GO:0006814,GO:0008137,GO:0008150,GO:0008152,GO:0015672,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0030001,GO:0030964,GO:0032991,GO:0044425,GO:0050136,GO:0051179,GO:0051234,GO:0055114,GO:0098796,GO:1902494 1.6.5.8 ko:K00346 - - - - ko00000,ko01000 - - - NQRA,NQRA_SLBB k59_1397404_2 565045.NOR51B_1703 5.35e-42 147.0 COG4658@1|root,COG4658@2|Bacteria,1MVY6@1224|Proteobacteria,1T20Y@1236|Gammaproteobacteria,1JC0A@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol nqrB - 1.6.5.8 ko:K00347,ko:K03614 - - - - ko00000,ko01000 - - - NQR2_RnfD_RnfE k59_431930_1 926549.KI421517_gene1458 9.67e-18 85.1 COG2010@1|root,COG2010@2|Bacteria,4NHQV@976|Bacteroidetes,47PEN@768503|Cytophagia 976|Bacteroidetes C Cytochrome c - - - - - - - - - - - - Cytochrom_C,Cytochrome_CBB3 k59_431930_2 1485545.JQLW01000007_gene733 1.92e-13 71.2 COG1055@1|root,COG1055@2|Bacteria,1MUX4@1224|Proteobacteria 1224|Proteobacteria P Involved in arsenical resistance. Thought to form the channel of an arsenite pump - - - - - - - - - - - - CitMHS k59_770006_1 395495.Lcho_0412 5.11e-92 296.0 COG0021@1|root,COG0176@1|root,COG0021@2|Bacteria,COG0176@2|Bacteria,1MUEY@1224|Proteobacteria,2VHNX@28216|Betaproteobacteria,1KKID@119065|unclassified Burkholderiales 28216|Betaproteobacteria H Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway tkt - 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 - - - Transket_pyr,Transketolase_C,Transketolase_N k59_1169289_1 56780.SYN_02063 1.18e-33 128.0 COG3528@1|root,COG3528@2|Bacteria,1R601@1224|Proteobacteria,42Q98@68525|delta/epsilon subdivisions,2WM5S@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Uncharacterized protein conserved in bacteria (DUF2219) - - - - - - - - - - - - DUF2219 k59_1675268_1 1122222.AXWR01000003_gene1420 9.95e-45 160.0 COG3118@1|root,COG3118@2|Bacteria 2|Bacteria O belongs to the thioredoxin family - - - ko:K20543 - - - - ko00000,ko02000 1.B.55.3 - - Arylsulfotran_2,UnbV_ASPIC,VCBS k59_487733_1 1229276.DI53_1451 6.69e-25 100.0 COG4731@1|root,COG4731@2|Bacteria,4NQCK@976|Bacteroidetes,1ITGD@117747|Sphingobacteriia 976|Bacteroidetes S protein conserved in bacteria - - - - - - - - - - - - DUF2147 k59_719123_1 857087.Metme_2701 3.55e-29 130.0 COG1858@1|root,COG1858@2|Bacteria,1RC4D@1224|Proteobacteria,1SJKT@1236|Gammaproteobacteria,1XFYK@135618|Methylococcales 135618|Methylococcales C cytochrome C peroxidase - - - - - - - - - - - - - k59_1399031_2 1403819.BATR01000112_gene3748 5.71e-22 104.0 COG0500@1|root,COG0742@1|root,COG4122@1|root,COG0742@2|Bacteria,COG2226@2|Bacteria,COG4122@2|Bacteria 2|Bacteria E O-methyltransferase activity ubiE1 - - ko:K15257,ko:K20444 - - - - ko00000,ko01000,ko01005,ko02000,ko03016 4.D.1.3 GT2,GT4 - Cons_hypoth95,Methyltransf_11,SAM_MT k59_433499_1 880073.Calab_3554 1.32e-96 307.0 COG0532@1|root,COG0532@2|Bacteria,2NNRG@2323|unclassified Bacteria 2|Bacteria J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex infB GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - ko:K02519 - - - - ko00000,ko03012,ko03029 - - - GTP_EFTU,GTP_EFTU_D2,IF-2,IF2_N k59_890639_1 62928.azo2353 4.56e-65 200.0 COG0394@1|root,COG0394@2|Bacteria,1REU2@1224|Proteobacteria,2VS5B@28216|Betaproteobacteria 28216|Betaproteobacteria T Low molecular weight phosphatase family - - 1.20.4.1 ko:K03741 - - - - ko00000,ko01000 - - - LMWPc k59_890639_2 204773.HEAR1107 8.25e-44 152.0 COG0226@1|root,COG0226@2|Bacteria,1MUAZ@1224|Proteobacteria,2VIJV@28216|Betaproteobacteria,472HC@75682|Oxalobacteraceae 28216|Betaproteobacteria P Part of the ABC transporter complex PstSACB involved in phosphate import pstS - - ko:K02040 ko02010,ko02020,ko05152,map02010,map02020,map05152 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - PBP_like_2 k59_489260_1 1380763.BG53_00700 8.91e-64 216.0 COG0210@1|root,COG0210@2|Bacteria,1TPSU@1239|Firmicutes,4HB12@91061|Bacilli,26QTI@186822|Paenibacillaceae 91061|Bacilli L ATP-dependent DNA helicase pcrA - 3.6.4.12 ko:K03657 ko03420,ko03430,map03420,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - UvrD-helicase,UvrD_C k59_997415_1 1229909.NSED_06505 2.21e-107 318.0 COG0045@1|root,arCOG01337@2157|Archaea,41S5M@651137|Thaumarchaeota 651137|Thaumarchaeota C ATP-grasp domain - - 6.2.1.5 ko:K01903 ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374,M00620 R00405,R02404 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000 - - - ATP-grasp_2,Ligase_CoA k59_941708_1 1381123.AYOD01000068_gene209 0.000934 46.6 COG1194@1|root,COG1194@2|Bacteria,1MUD4@1224|Proteobacteria,2TQVX@28211|Alphaproteobacteria,43HPK@69277|Phyllobacteriaceae 28211|Alphaproteobacteria L TIGRFAM A G-specific adenine glycosylase mutY GO:0003674,GO:0003824,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360 - ko:K03575 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - EndIII_4Fe-2S,HhH-GPD,NUDIX_4 k59_941708_2 587753.EY04_19325 2.06e-05 46.6 COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,1RSDZ@1236|Gammaproteobacteria 1236|Gammaproteobacteria T Histidine kinase - - 2.7.13.3 ko:K02482 - - - - ko00000,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA,Response_reg k59_890655_1 1041522.MCOL_V214249 6.42e-26 103.0 COG2175@1|root,COG2175@2|Bacteria,2I8RZ@201174|Actinobacteria,2363N@1762|Mycobacteriaceae 201174|Actinobacteria Q taurine catabolism dioxygenase - - - - - - - - - - - - TauD k59_1734802_2 596152.DesU5LDRAFT_3947 6.58e-37 133.0 COG0501@1|root,COG0501@2|Bacteria,1MUV4@1224|Proteobacteria,42MEE@68525|delta/epsilon subdivisions,2WJYV@28221|Deltaproteobacteria,2M824@213115|Desulfovibrionales 28221|Deltaproteobacteria O Belongs to the peptidase M48B family htpX - - ko:K03799 - M00743 - - ko00000,ko00002,ko01000,ko01002 - - - Peptidase_M48 k59_771563_1 635013.TherJR_1377 6.26e-55 192.0 COG0532@1|root,COG0532@2|Bacteria,1TPAI@1239|Firmicutes,248SJ@186801|Clostridia,260ER@186807|Peptococcaceae 186801|Clostridia J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex infB - - ko:K02519 - - - - ko00000,ko03012,ko03029 - - - GTP_EFTU,IF-2,IF2_N k59_771563_2 1463857.JOFZ01000013_gene1367 2.9e-08 52.4 COG1550@1|root,COG1550@2|Bacteria,2IQW4@201174|Actinobacteria 201174|Actinobacteria S protein conserved in bacteria - - - ko:K09764 - - - - ko00000 - - - DUF503 k59_1111656_1 2002.JOEQ01000003_gene2490 4.13e-78 244.0 COG0031@1|root,COG0031@2|Bacteria,2GIXE@201174|Actinobacteria,4EI60@85012|Streptosporangiales 201174|Actinobacteria EK Pyridoxal-phosphate dependent enzyme - - 2.5.1.47 ko:K01738 ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230 M00021 R00897,R03601,R04859 RC00020,RC02814,RC02821 ko00000,ko00001,ko00002,ko01000 - - - PALP k59_890656_1 566466.NOR53_1079 7.48e-64 204.0 COG0774@1|root,COG0774@2|Bacteria,1MV6T@1224|Proteobacteria,1RQ72@1236|Gammaproteobacteria,1J54C@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis lpxC GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008270,GO:0008610,GO:0008654,GO:0008759,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016787,GO:0016810,GO:0016811,GO:0019213,GO:0019637,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044464,GO:0046467,GO:0046493,GO:0046872,GO:0046914,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 3.5.1.108 ko:K02535 ko00540,ko01100,map00540,map01100 M00060 R04587 RC00166,RC00300 ko00000,ko00001,ko00002,ko01000,ko01005 - - iECS88_1305.ECS88_0100 LpxC k59_152523_1 644282.Deba_2429 3.47e-11 66.2 COG2885@1|root,COG2885@2|Bacteria,1MZTV@1224|Proteobacteria,42R5H@68525|delta/epsilon subdivisions,2WNZS@28221|Deltaproteobacteria 28221|Deltaproteobacteria M Belongs to the ompA family pal - - ko:K03640 - - - - ko00000,ko02000 2.C.1.2 - - OmpA k59_1226714_1 314607.KB13_294 4.56e-13 71.6 COG1999@1|root,COG1999@2|Bacteria,1N6R6@1224|Proteobacteria 1224|Proteobacteria S signal sequence binding VVA1110 - - - - - - - - - - - - k59_433560_1 926550.CLDAP_17820 5.57e-98 305.0 COG0370@1|root,COG0370@2|Bacteria,2G5RW@200795|Chloroflexi 200795|Chloroflexi P transporter of a GTP-driven Fe(2 ) uptake system - - - ko:K04759 - - - - ko00000,ko02000 9.A.8.1 - - FeoB_C,Gate k59_325671_1 1244869.H261_04842 5.44e-94 293.0 COG0318@1|root,COG0318@2|Bacteria,1MUQZ@1224|Proteobacteria,2TRV7@28211|Alphaproteobacteria,2JPYI@204441|Rhodospirillales 204441|Rhodospirillales IQ AMP-binding enzyme - - 6.2.1.34 ko:K12508 - - - - ko00000,ko01000 - - - AMP-binding k59_890664_1 1122164.JHWF01000021_gene1207 1.53e-43 161.0 COG1331@1|root,COG1331@2|Bacteria,1MUUT@1224|Proteobacteria,1RSQQ@1236|Gammaproteobacteria,1JFQP@118969|Legionellales 118969|Legionellales O Protein of unknown function, DUF255 - - - - - - - - - - - - Thioredox_DsbH k59_210174_1 472759.Nhal_1348 3.82e-22 100.0 COG1858@1|root,COG1858@2|Bacteria,1RC4D@1224|Proteobacteria,1SJKT@1236|Gammaproteobacteria 1236|Gammaproteobacteria C cytochrome C peroxidase - - - - - - - - - - - - - k59_720657_1 436308.Nmar_1186 3.69e-73 228.0 arCOG08642@1|root,arCOG08642@2157|Archaea,41T1T@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_830408_1 1120953.AUBH01000011_gene449 3.65e-59 205.0 COG0577@1|root,COG0577@2|Bacteria,1MW6D@1224|Proteobacteria,1RN49@1236|Gammaproteobacteria,465XQ@72275|Alteromonadaceae 1236|Gammaproteobacteria V FtsX-like permease family - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_489311_1 882.DVU_1272 1.26e-96 302.0 COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,42M51@68525|delta/epsilon subdivisions,2WIPP@28221|Deltaproteobacteria,2M915@213115|Desulfovibrionales 28221|Deltaproteobacteria NU PFAM Type II secretion system protein E - - - ko:K02652 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE,T2SSE_N k59_50775_1 247634.GPB2148_2723 2.04e-139 426.0 COG0612@1|root,COG0612@2|Bacteria,1MVST@1224|Proteobacteria,1RN05@1236|Gammaproteobacteria,1J4IJ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Zn-dependent peptidases pqqL - - ko:K07263 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M16,Peptidase_M16_C k59_50779_1 1121434.AULY01000006_gene929 2.06e-85 274.0 COG0668@1|root,COG0668@2|Bacteria,1MXD2@1224|Proteobacteria,43C4Y@68525|delta/epsilon subdivisions,2X7FA@28221|Deltaproteobacteria 28221|Deltaproteobacteria M Mechanosensitive ion channel - - - - - - - - - - - - MS_channel k59_1408167_1 1229909.NSED_00370 5.58e-29 104.0 arCOG08823@1|root,arCOG08823@2157|Archaea,41SW2@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1408167_2 436308.Nmar_0180 5.89e-66 205.0 COG2085@1|root,arCOG00457@2157|Archaea,41SH2@651137|Thaumarchaeota 651137|Thaumarchaeota S PFAM NADP oxidoreductase coenzyme F420-dependent - - 1.5.1.40 ko:K06988 - - - - ko00000,ko01000 - - - F420_oxidored k59_106811_1 395493.BegalDRAFT_3005 1.75e-09 60.8 COG2802@1|root,COG2802@2|Bacteria,1RFYH@1224|Proteobacteria,1S54H@1236|Gammaproteobacteria,462T3@72273|Thiotrichales 72273|Thiotrichales S ATP-dependent protease La (LON) substrate-binding domain - - - ko:K07157 - - - - ko00000 - - - LON_substr_bdg k59_1234704_1 948106.AWZT01000007_gene3482 1.58e-42 157.0 COG1066@1|root,COG1066@2|Bacteria,1MUJQ@1224|Proteobacteria,2VH93@28216|Betaproteobacteria,1K1ZE@119060|Burkholderiaceae 28216|Betaproteobacteria O DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function radA - - ko:K04485 - - - - ko00000,ko03400 - - - AAA_25,ATPase,ChlI,Lon_C k59_1234704_2 1283287.KB822593_gene1299 2.51e-13 68.2 COG1309@1|root,COG1309@2|Bacteria,2IQGF@201174|Actinobacteria,4DRWJ@85009|Propionibacteriales 201174|Actinobacteria K Bacterial regulatory proteins, tetR family - - - - - - - - - - - - TetR_N k59_1234705_1 269796.Rru_A1008 2.38e-101 305.0 COG1397@1|root,COG1397@2|Bacteria,1NTUR@1224|Proteobacteria,2U0DV@28211|Alphaproteobacteria,2JRFV@204441|Rhodospirillales 204441|Rhodospirillales O ADP-ribosylglycohydrolase draG - 3.2.2.24 ko:K05521 - - - - ko00000,ko01000 - - - ADP_ribosyl_GH k59_50803_1 1041146.ATZB01000051_gene1045 6.73e-28 117.0 COG2199@1|root,COG4192@1|root,COG5002@1|root,COG3706@2|Bacteria,COG4192@2|Bacteria,COG5002@2|Bacteria,1R7HC@1224|Proteobacteria,2TZD4@28211|Alphaproteobacteria,4BP1D@82115|Rhizobiaceae 28211|Alphaproteobacteria T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - CHASE3,GAF_2,HAMP,HATPase_c,HisKA,PAS_7,Response_reg k59_276477_1 314256.OG2516_17266 1.15e-90 277.0 COG0668@1|root,COG0668@2|Bacteria,1MW7V@1224|Proteobacteria,2TT0A@28211|Alphaproteobacteria 28211|Alphaproteobacteria M mechanosensitive ion channel - - - - - - - - - - - - MS_channel k59_1067216_1 1424334.W822_08830 1.15e-76 244.0 COG0065@1|root,COG0065@2|Bacteria,1MVYR@1224|Proteobacteria,2VHVF@28216|Betaproteobacteria 28216|Betaproteobacteria H Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate - - 4.2.1.33,4.2.1.35 ko:K01703 ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230 M00432,M00535 R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170 RC00497,RC00976,RC00977,RC01041,RC01046,RC03072 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase k59_616275_1 1122137.AQXF01000007_gene3622 1.84e-104 322.0 COG0376@1|root,COG0376@2|Bacteria,1MUBF@1224|Proteobacteria,2TQJ7@28211|Alphaproteobacteria 28211|Alphaproteobacteria P Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity katG - 1.11.1.21 ko:K03782 ko00360,ko00380,ko00940,ko00983,ko01100,ko01110,map00360,map00380,map00940,map00983,map01100,map01110 - R00602,R00698,R02596,R02670,R03919,R04007,R07443,R11906 RC00034,RC00213,RC00767,RC02141 ko00000,ko00001,ko01000 - - - peroxidase k59_729538_2 1265313.HRUBRA_01862 2.15e-45 152.0 COG0315@1|root,COG0315@2|Bacteria,1RCYZ@1224|Proteobacteria,1S3ST@1236|Gammaproteobacteria,1J5Z2@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP) moaC GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006732,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016043,GO:0016829,GO:0016849,GO:0018130,GO:0019538,GO:0019637,GO:0019720,GO:0022607,GO:0034214,GO:0042802,GO:0043170,GO:0043545,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0046483,GO:0051186,GO:0051188,GO:0051189,GO:0051259,GO:0061799,GO:0065003,GO:0071704,GO:0071840,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.6.1.17 ko:K03637 ko00790,ko01100,ko04122,map00790,map01100,map04122 - R11372 RC03425 ko00000,ko00001,ko01000 - - - MoCF_biosynth,MoaC k59_779627_1 1198232.CYCME_1719 2.88e-53 188.0 COG0013@1|root,COG0013@2|Bacteria,1MU9A@1224|Proteobacteria,1RMWZ@1236|Gammaproteobacteria,45ZUH@72273|Thiotrichales 72273|Thiotrichales J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain alaS - 6.1.1.7 ko:K01872 ko00970,map00970 M00359,M00360 R03038 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DHHA1,tRNA-synt_2c,tRNA_SAD k59_276488_1 1207055.C100_13875 1.44e-38 138.0 COG1260@1|root,COG1260@2|Bacteria,1N0D9@1224|Proteobacteria,2TSH8@28211|Alphaproteobacteria,2K1V4@204457|Sphingomonadales 204457|Sphingomonadales I Inositol-3-phosphate synthase - - 5.5.1.4 ko:K01858 ko00521,ko00562,ko01100,ko01130,map00521,map00562,map01100,map01130 - R07324 RC01804 ko00000,ko00001,ko01000 - - - Inos-1-P_synth k59_276488_2 472759.Nhal_0372 6.05e-27 107.0 COG1260@1|root,COG1260@2|Bacteria,1N0D9@1224|Proteobacteria,1RZ5M@1236|Gammaproteobacteria 1236|Gammaproteobacteria I Myo-inositol-1-phosphate synthase - - 5.5.1.4 ko:K01858 ko00521,ko00562,ko01100,ko01130,map00521,map00562,map01100,map01130 - R07324 RC01804 ko00000,ko00001,ko01000 - - - Inos-1-P_synth k59_276488_3 479434.Sthe_1778 2.3e-58 191.0 COG0705@1|root,COG0705@2|Bacteria,2G6J5@200795|Chloroflexi,27Y4W@189775|Thermomicrobia 189775|Thermomicrobia S Rhomboid family - - - - - - - - - - - - Rhomboid k59_1234721_1 1121022.ABENE_23565 1.28e-74 234.0 COG3335@1|root,COG3335@2|Bacteria,1MW7X@1224|Proteobacteria,2TTH8@28211|Alphaproteobacteria,2KHTR@204458|Caulobacterales 204458|Caulobacterales L Winged helix-turn helix - - - - - - - - - - - - DDE_3 k59_1408208_1 99598.Cal7507_5198 1.96e-15 72.0 COG0117@1|root,COG0117@2|Bacteria,1GI07@1117|Cyanobacteria,1HS74@1161|Nostocales 1117|Cyanobacteria H PFAM CMP dCMP deaminase, zinc-binding - - - - - - - - - - - - dCMP_cyt_deam_1 k59_729551_1 339670.Bamb_3587 2.05e-44 158.0 COG0845@1|root,COG0845@2|Bacteria,1MUI8@1224|Proteobacteria,2VIAA@28216|Betaproteobacteria,1K8Z6@119060|Burkholderiaceae 28216|Betaproteobacteria M type I secretion membrane fusion - - - ko:K02022,ko:K12537 - M00328 - - ko00000,ko00002,ko02000,ko02044 8.A.1 - - HlyD,HlyD_3 k59_1119995_1 523791.Kkor_2556 0.000267 49.3 COG2834@1|root,COG2834@2|Bacteria,1MXW0@1224|Proteobacteria,1RS0K@1236|Gammaproteobacteria,1XHXM@135619|Oceanospirillales 135619|Oceanospirillales M Outer membrane lipoprotein-sorting protein - - - - - - - - - - - - LolA_like k59_780815_2 1088721.NSU_2921 2.57e-116 346.0 COG0477@1|root,COG2814@2|Bacteria,1QTWR@1224|Proteobacteria,2TW1S@28211|Alphaproteobacteria,2K09D@204457|Sphingomonadales 204457|Sphingomonadales EGP Major facilitator superfamily - - - - - - - - - - - - MFS_1 k59_554329_1 436308.Nmar_1745 4.53e-70 218.0 COG0524@1|root,arCOG00014@2157|Archaea,41SX4@651137|Thaumarchaeota 651137|Thaumarchaeota G pfkB family carbohydrate kinase - - - - - - - - - - - - PfkB k59_554329_2 1229909.NSED_09295 1.85e-28 104.0 arCOG08766@1|root,arCOG08766@2157|Archaea,41T41@651137|Thaumarchaeota 651137|Thaumarchaeota G dUTPase - - - - - - - - - - - - dUTPase_2 k59_900603_1 326297.Sama_0235 4.74e-55 174.0 COG0099@1|root,COG0099@2|Bacteria,1RD1G@1224|Proteobacteria,1S3NX@1236|Gammaproteobacteria,2QBVP@267890|Shewanellaceae 1236|Gammaproteobacteria J Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits rpsM GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022613,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02952 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S13 k59_900603_2 987059.RBXJA2T_02240 1.09e-08 53.5 COG0100@1|root,COG0100@2|Bacteria,1RD0A@1224|Proteobacteria,2VR8I@28216|Betaproteobacteria,1KKRV@119065|unclassified Burkholderiales 28216|Betaproteobacteria J Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome rpsK - - ko:K02948 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S11 k59_219568_1 1136138.JH604622_gene557 8.27e-32 127.0 COG0768@1|root,COG0769@1|root,COG0768@2|Bacteria,COG0769@2|Bacteria,1MUNY@1224|Proteobacteria,1RNGW@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Catalyzes cross-linking of the peptidoglycan cell wall at the division septum ftsI GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008144,GO:0008150,GO:0008658,GO:0008955,GO:0009987,GO:0016020,GO:0016021,GO:0016740,GO:0016757,GO:0016758,GO:0031224,GO:0031226,GO:0031406,GO:0032153,GO:0033218,GO:0033293,GO:0036094,GO:0042221,GO:0042493,GO:0043167,GO:0043168,GO:0043177,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051301,GO:0071944,GO:0097159,GO:1901363,GO:1901681 3.4.16.4 ko:K03587 ko00550,ko01501,map00550,map01501 - - - ko00000,ko00001,ko01000,ko01011,ko03036 - - iSSON_1240.SSON_0092 PBP_dimer,Transpeptidase k59_1631891_2 756275.H2BCT8_9CAUD 4.01e-09 62.8 4QMPJ@10699|Siphoviridae 10699|Siphoviridae - - - - - - - - - - - - - - - k59_1007033_1 404589.Anae109_4161 3.39e-61 210.0 COG3005@1|root,COG3005@2|Bacteria,1NT6I@1224|Proteobacteria,42YAG@68525|delta/epsilon subdivisions,2WTY3@28221|Deltaproteobacteria 28221|Deltaproteobacteria C denitrification pathway - - - - - - - - - - - - - k59_162432_1 1140002.I570_00715 7.39e-08 53.5 COG2207@1|root,COG4936@1|root,COG2207@2|Bacteria,COG4936@2|Bacteria,1UZ4I@1239|Firmicutes,4ISI4@91061|Bacilli,4B453@81852|Enterococcaceae 91061|Bacilli K helix_turn_helix, arabinose operon control protein - - - - - - - - - - - - AraC_binding,HTH_18,HTH_AraC k59_1796459_1 225849.swp_1561 5.38e-79 244.0 COG1216@1|root,COG1216@2|Bacteria,1N1TF@1224|Proteobacteria,1RPQU@1236|Gammaproteobacteria,2QCVZ@267890|Shewanellaceae 1236|Gammaproteobacteria S Glycosyltransferase like family 2 - - - ko:K12992 ko02025,map02025 - - - ko00000,ko00001,ko01000,ko01003,ko01005 - GT2 - Glycos_transf_2 k59_900638_1 697282.Mettu_3625 3.27e-107 321.0 COG2801@1|root,COG2801@2|Bacteria,1MXKK@1224|Proteobacteria,1RSMZ@1236|Gammaproteobacteria 1236|Gammaproteobacteria L PFAM Integrase - - - - - - - - - - - - - k59_52018_1 357808.RoseRS_4002 8.72e-79 240.0 COG1126@1|root,COG1126@2|Bacteria,2G5UB@200795|Chloroflexi,376F8@32061|Chloroflexia 32061|Chloroflexia E PFAM ABC transporter related - - - ko:K09972 ko02010,map02010 M00232 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.3.17,3.A.1.3.18,3.A.1.3.7,3.A.1.3.8 - - ABC_tran k59_107986_1 1229909.NSED_09780 2.93e-98 291.0 COG5491@1|root,arCOG00452@2157|Archaea,41SYC@651137|Thaumarchaeota 651137|Thaumarchaeota D conserved protein implicated in secretion - - - - - - - - - - - - - k59_951466_4 1449126.JQKL01000051_gene3168 8.18e-23 98.2 2CK39@1|root,32SBG@2|Bacteria,1V8KG@1239|Firmicutes,249UQ@186801|Clostridia 186801|Clostridia S Phage gp6-like head-tail connector protein - - - - - - - - - - - - Phage_connect_1 k59_219588_1 875328.JDM601_2354 5.79e-06 46.6 COG2050@1|root,COG2050@2|Bacteria,2IQXX@201174|Actinobacteria,23BW8@1762|Mycobacteriaceae 201174|Actinobacteria Q Thioesterase superfamily - - - - - - - - - - - - 4HBT k59_52028_1 1528106.JRJE01000032_gene2919 2.8e-83 263.0 COG1508@1|root,COG1508@2|Bacteria,1MW4V@1224|Proteobacteria,2TS41@28211|Alphaproteobacteria,2JPA9@204441|Rhodospirillales 204441|Rhodospirillales K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released rpoN - - ko:K03092 ko02020,ko05111,map02020,map05111 - - - ko00000,ko00001,ko03021 - - - Sigma54_AID,Sigma54_CBD,Sigma54_DBD k59_107998_1 247634.GPB2148_2978 7.81e-24 103.0 COG0022@1|root,COG0022@2|Bacteria,1R8KB@1224|Proteobacteria,1RP3G@1236|Gammaproteobacteria,1J8DU@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C COG0022 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit acoB - - ko:K21417 - - - - ko00000,ko01000 - - - Transket_pyr,Transketolase_C k59_1631930_1 700598.Niako_2356 1.57e-16 84.3 COG5549@1|root,COG5549@2|Bacteria,4NEA0@976|Bacteroidetes,1IQA8@117747|Sphingobacteriia 976|Bacteroidetes O Domain of unknown function (DUF5118) - - - - - - - - - - - - DUF4953,DUF5117,DUF5118 k59_1068348_1 1415778.JQMM01000001_gene1832 1.95e-76 256.0 COG1643@1|root,COG1643@2|Bacteria,1MUEQ@1224|Proteobacteria,1RMU1@1236|Gammaproteobacteria,1J5AR@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L COG1643 HrpA-like helicases hrpA GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0006139,GO:0006396,GO:0006397,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0034641,GO:0042623,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0070035,GO:0071704,GO:0090304,GO:0140098,GO:1901360 3.6.4.13 ko:K03578 - - - - ko00000,ko01000 - - - DEAD,DUF3418,HA2,Helicase_C,OB_NTP_bind k59_1687223_1 443143.GM18_2447 1.96e-36 140.0 COG1269@1|root,COG1269@2|Bacteria,1QGFB@1224|Proteobacteria,42UWC@68525|delta/epsilon subdivisions,2X5C3@28221|Deltaproteobacteria 28221|Deltaproteobacteria C PFAM V-type ATPase 116 kDa - - - ko:K02123 ko00190,ko01100,map00190,map01100 M00159 - - ko00000,ko00001,ko00002 3.A.2.2,3.A.2.3 - - - k59_900653_1 436308.Nmar_1322 1.77e-43 156.0 COG3569@1|root,arCOG08649@2157|Archaea,41SDH@651137|Thaumarchaeota 651137|Thaumarchaeota L DNA Topoisomerase I (eukaryota) - - 5.99.1.2 ko:K03163 - - - - ko00000,ko01000,ko03032 - - - Topo_C_assoc,Topoisom_I,Topoisom_I_N k59_1007068_1 1379270.AUXF01000004_gene3238 7.65e-84 261.0 COG0162@1|root,COG0162@2|Bacteria,1ZT43@142182|Gemmatimonadetes 142182|Gemmatimonadetes J Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) tyrS - 6.1.1.1 ko:K01866 ko00970,map00970 M00359,M00360 R02918 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - S4,tRNA-synt_1b k59_1068355_1 1229909.NSED_03070 6.69e-82 253.0 COG1253@1|root,arCOG00626@2157|Archaea 2157|Archaea S COG1253 Hemolysins and related proteins containing CBS domains cbs9 - - ko:K03699 - - - - ko00000,ko02042 - - - CBS,CorC_HlyC,DUF21 k59_108020_1 472759.Nhal_3812 1.97e-16 77.8 COG0550@1|root,COG1754@1|root,COG0550@2|Bacteria,COG1754@2|Bacteria,1MUFZ@1224|Proteobacteria,1RNZ2@1236|Gammaproteobacteria,1WWWP@135613|Chromatiales 135613|Chromatiales L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone topA - 5.99.1.2 ko:K03168 - - - - ko00000,ko01000,ko03032,ko03400 - - - Topo_Zn_Ribbon,Topoisom_bac,Toprim,Toprim_C_rpt,zf-C4_Topoisom k59_108020_2 765912.Thimo_1250 1.23e-31 117.0 COG2922@1|root,COG2922@2|Bacteria,1RD5F@1224|Proteobacteria,1S43X@1236|Gammaproteobacteria,1WYZ6@135613|Chromatiales 135613|Chromatiales S Belongs to the Smg family smg - - ko:K03747 - - - - ko00000 - - - DUF494 k59_1744173_1 339670.Bamb_0173 4.52e-52 174.0 COG1871@1|root,COG1871@2|Bacteria,1RDDB@1224|Proteobacteria,2VJ1T@28216|Betaproteobacteria,1KH3B@119060|Burkholderiaceae 28216|Betaproteobacteria NT Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis cheD - 3.5.1.44 ko:K03411 ko02030,map02030 - - - ko00000,ko00001,ko01000,ko02035 - - - CheD k59_1744173_2 1500890.JQNL01000001_gene3135 3.43e-46 159.0 COG2201@1|root,COG2201@2|Bacteria,1MWCN@1224|Proteobacteria,1RN67@1236|Gammaproteobacteria,1X3IE@135614|Xanthomonadales 135614|Xanthomonadales NT catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR cheB - 3.1.1.61,3.5.1.44 ko:K03412 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko02022,ko02035 - - - CheB_methylest,Response_reg k59_780881_1 314254.OA2633_03791 1.57e-37 152.0 COG3209@1|root,COG3209@2|Bacteria,1MVV1@1224|Proteobacteria,2U4RY@28211|Alphaproteobacteria,43YWV@69657|Hyphomonadaceae 28211|Alphaproteobacteria M TIGRFAM RHS repeat-associated core domain-containing protein, YD repeat protein - - - - - - - - - - - - RHS_repeat,SpvB,TcdB_toxin_midN k59_1521596_1 90675.XP_010478024.1 1.93e-20 93.6 COG1028@1|root,KOG1200@2759|Eukaryota,37J83@33090|Viridiplantae,3GAYA@35493|Streptophyta,3HUG3@3699|Brassicales 35493|Streptophyta Q reductase - GO:0003674,GO:0003824,GO:0004312,GO:0004316,GO:0005488,GO:0005507,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0009507,GO:0009526,GO:0009532,GO:0009536,GO:0009570,GO:0009941,GO:0016491,GO:0016614,GO:0016616,GO:0016740,GO:0016746,GO:0016747,GO:0031967,GO:0031975,GO:0043167,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0046872,GO:0046914,GO:0055114 1.1.1.100 ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short,adh_short_C2 k59_108028_1 1122137.AQXF01000002_gene269 1.05e-72 243.0 COG4232@1|root,COG4233@1|root,COG4232@2|Bacteria,COG4233@2|Bacteria,1MU8W@1224|Proteobacteria,2TTUM@28211|Alphaproteobacteria 28211|Alphaproteobacteria CO to be involved in C-type cytochrome biogenesis dsbD - 1.8.1.8 ko:K04084 - - - - ko00000,ko01000,ko03110 5.A.1.1 - - DsbC,DsbD,Thioredoxin_7 k59_108028_2 751945.Theos_1806 6.04e-27 112.0 COG2379@1|root,COG2379@2|Bacteria,1WI14@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus G Hydroxypyruvate reductase - - 2.7.1.165 ko:K11529 ko00030,ko00260,ko00561,ko00630,ko00680,ko01100,ko01120,ko01130,ko01200,map00030,map00260,map00561,map00630,map00680,map01100,map01120,map01130,map01200 M00346 R08572 RC00002,RC00428 ko00000,ko00001,ko00002,ko01000 - - - DUF4147,MOFRL k59_1007085_1 626887.J057_10951 4.25e-16 76.6 COG2197@1|root,COG2197@2|Bacteria,1PXTY@1224|Proteobacteria,1RMPW@1236|Gammaproteobacteria,466JI@72275|Alteromonadaceae 1236|Gammaproteobacteria K COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain agmR - - ko:K07684 ko02020,map02020 M00471 - - ko00000,ko00001,ko00002,ko02022 - - - GerE,Response_reg k59_1007085_2 95619.PM1_0222560 1.6e-33 123.0 COG0842@1|root,COG0842@2|Bacteria,1MVUG@1224|Proteobacteria,1RNF7@1236|Gammaproteobacteria 1236|Gammaproteobacteria V Transport Permease Protein pedC - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane k59_554380_1 754476.Q7A_1355 4.26e-40 142.0 COG4105@1|root,COG4105@2|Bacteria,1MVS5@1224|Proteobacteria,1RSE6@1236|Gammaproteobacteria,460GM@72273|Thiotrichales 72273|Thiotrichales M Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane bamD - - ko:K05807 - - - - ko00000,ko02000 1.B.33.1 - - YfiO k59_669628_1 702113.PP1Y_AT34181 3.54e-87 269.0 291EX@1|root,2ZP1S@2|Bacteria,1RF3T@1224|Proteobacteria,2U83Z@28211|Alphaproteobacteria,2K4S8@204457|Sphingomonadales 204457|Sphingomonadales - - - - - - - - - - - - - - Mitofilin k59_730732_1 1122137.AQXF01000001_gene3177 1.63e-131 377.0 COG0101@1|root,COG0101@2|Bacteria,1MUYI@1224|Proteobacteria,2TR57@28211|Alphaproteobacteria 28211|Alphaproteobacteria J Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs truA GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016853,GO:0016866,GO:0031119,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360 5.4.99.12 ko:K06173 - - - - ko00000,ko01000,ko03016 - - - PseudoU_synth_1 k59_730732_2 1122137.AQXF01000001_gene3176 5.89e-52 167.0 COG1762@1|root,COG1762@2|Bacteria,1RD0E@1224|Proteobacteria,2U7B0@28211|Alphaproteobacteria 28211|Alphaproteobacteria G PTS IIA-like nitrogen-regulatory protein PtsN ptsN2 - - ko:K02806 ko02060,map02060 - - - ko00000,ko00001,ko01000,ko02000 - - - PTS_EIIA_2 k59_1121184_1 1122137.AQXF01000006_gene708 3.06e-113 352.0 COG1861@1|root,COG3980@1|root,COG1861@2|Bacteria,COG3980@2|Bacteria,1RG42@1224|Proteobacteria,2UABZ@28211|Alphaproteobacteria 28211|Alphaproteobacteria M PFAM acylneuraminate cytidylyltransferase - - - ko:K07257 - - - - ko00000 - - - CTP_transf_3 k59_617557_1 196367.JNFG01000009_gene6338 8.77e-50 174.0 COG5421@1|root,COG5421@2|Bacteria,1R3NX@1224|Proteobacteria,2VNNI@28216|Betaproteobacteria,1K3QF@119060|Burkholderiaceae 28216|Betaproteobacteria L Transposase DDE domain - - - - - - - - - - - - DDE_Tnp_1 k59_1796548_1 981085.XP_010089090.1 2.1e-22 97.4 COG1028@1|root,KOG1208@2759|Eukaryota,37Q3T@33090|Viridiplantae,3GBAM@35493|Streptophyta,4JE47@91835|fabids 35493|Streptophyta Q Short-chain dehydrogenase - GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0008150,GO:0008152,GO:0009507,GO:0009526,GO:0009528,GO:0009536,GO:0009706,GO:0009941,GO:0016020,GO:0016491,GO:0019866,GO:0031090,GO:0031967,GO:0031969,GO:0031975,GO:0042170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0055114,GO:0071944 1.1.1.300 ko:K11153,ko:K19329 ko00830,ko01100,map00830,map01100 - R08379,R08383 RC00649 ko00000,ko00001,ko01000 - - - adh_short k59_1796548_2 1108045.GORHZ_141_00050 4.59e-45 156.0 COG1028@1|root,COG1028@2|Bacteria,2I9FM@201174|Actinobacteria,4GATU@85026|Gordoniaceae 201174|Actinobacteria IQ Enoyl-(Acyl carrier protein) reductase fabG3_1 - - - - - - - - - - - adh_short_C2 k59_1007100_1 595494.Tola_0853 7.81e-94 288.0 COG0019@1|root,COG0019@2|Bacteria,1MZ7Y@1224|Proteobacteria,1RQJ4@1236|Gammaproteobacteria,1Y3PQ@135624|Aeromonadales 135624|Aeromonadales E Belongs to the Orn Lys Arg decarboxylase class-II family - - 4.1.1.17 ko:K01581 ko00330,ko00480,ko01100,ko01110,ko01130,map00330,map00480,map01100,map01110,map01130 M00134 R00670 RC00299 ko00000,ko00001,ko00002,ko01000 - - - Orn_Arg_deC_N,Orn_DAP_Arg_deC k59_951524_1 1081640.AGFU01000007_gene953 3.86e-10 67.0 COG3297@1|root,COG3297@2|Bacteria,1N91X@1224|Proteobacteria,2UIMU@28211|Alphaproteobacteria 28211|Alphaproteobacteria U Type II secretion system (T2SS), protein L - - - ko:K02461 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - T2SSL k59_1687269_1 1484460.JSWG01000006_gene2776 2.06e-115 348.0 COG0365@1|root,COG0365@2|Bacteria,4NEAD@976|Bacteroidetes,1HYA0@117743|Flavobacteriia 976|Bacteroidetes I Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA acsA - 6.2.1.1 ko:K01895 ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200 M00357 R00235,R00236,R00316,R00926,R01354 RC00004,RC00012,RC00043,RC00070,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000,ko01004 - - - ACAS_N,AMP-binding,AMP-binding_C k59_1068399_1 187303.BN69_2748 7.19e-28 118.0 COG2202@1|root,COG2208@1|root,COG3829@1|root,COG2202@2|Bacteria,COG2208@2|Bacteria,COG3829@2|Bacteria,1NWNJ@1224|Proteobacteria,2UBI3@28211|Alphaproteobacteria,370DM@31993|Methylocystaceae 28211|Alphaproteobacteria KT Sigma factor PP2C-like phosphatases - - - - - - - - - - - - PAS_9,SpoIIE k59_904524_2 1122137.AQXF01000002_gene330 4.06e-60 199.0 COG0305@1|root,COG0305@2|Bacteria,1MUG9@1224|Proteobacteria,2TSF9@28211|Alphaproteobacteria 28211|Alphaproteobacteria L it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins dnaB - 3.6.4.12 ko:K02314 ko03030,ko04112,map03030,map04112 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB,DnaB_C k59_1243578_1 521719.ATXQ01000009_gene885 1.71e-41 146.0 COG0583@1|root,COG0583@2|Bacteria,1MVA1@1224|Proteobacteria,1RPAJ@1236|Gammaproteobacteria,1YDNX@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria K LysR substrate binding domain oxyR - - ko:K04761 ko02026,map02026 - - - ko00000,ko00001,ko03000 - - - HTH_1,LysR_substrate k59_339735_2 1229909.NSED_09465 9.96e-92 275.0 COG0517@1|root,arCOG00600@2157|Archaea,41TAT@651137|Thaumarchaeota 651137|Thaumarchaeota S CBS domain - - - - - - - - - - - - CBS k59_1187087_3 1379270.AUXF01000007_gene990 3.27e-64 200.0 COG5470@1|root,COG5470@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - DUF1330 k59_396017_1 999541.bgla_1g24430 1.29e-37 136.0 COG1028@1|root,COG1028@2|Bacteria,1P9R4@1224|Proteobacteria,2VPSA@28216|Betaproteobacteria,1K4V6@119060|Burkholderiaceae 28216|Betaproteobacteria IQ Enoyl-(Acyl carrier protein) reductase - - - - - - - - - - - - adh_short k59_1073980_1 748224.HMPREF9436_00866 1.29e-16 80.9 COG1052@1|root,COG1052@2|Bacteria,1TPCX@1239|Firmicutes,248UR@186801|Clostridia,3WG9C@541000|Ruminococcaceae 186801|Clostridia CH D-isomer specific 2-hydroxyacid dehydrogenase - - 1.1.1.29,1.1.1.399,1.1.1.95 ko:K00018,ko:K00058 ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200,map01230 M00020,M00346 R00717,R01388,R01513 RC00031,RC00042 ko00000,ko00001,ko00002,ko01000,ko04147 - - - 2-Hacid_dh,2-Hacid_dh_C k59_1073980_2 1396858.Q666_01205 1.16e-54 175.0 COG2983@1|root,COG2983@2|Bacteria,1RHMX@1224|Proteobacteria,1S5XU@1236|Gammaproteobacteria,46785@72275|Alteromonadaceae 1236|Gammaproteobacteria S Belongs to the UPF0260 family ycgN - - ko:K09160 - - - - ko00000 - - - CxxCxxCC k59_1073980_3 420324.KI911965_gene734 6.47e-75 231.0 COG0778@1|root,COG0778@2|Bacteria,1MY39@1224|Proteobacteria,2TTZC@28211|Alphaproteobacteria 28211|Alphaproteobacteria C COG0778 Nitroreductase - - - - - - - - - - - - Nitroreductase k59_1583520_2 460265.Mnod_1459 1.89e-40 142.0 COG2513@1|root,COG2513@2|Bacteria,1N4VT@1224|Proteobacteria,2TTP8@28211|Alphaproteobacteria,1JVBX@119045|Methylobacteriaceae 28211|Alphaproteobacteria G Isocitrate lyase family - - - - - - - - - - - - PEP_mutase k59_1527182_2 215803.DB30_8791 6.78e-36 136.0 COG2267@1|root,COG2303@1|root,COG2908@1|root,COG2267@2|Bacteria,COG2303@2|Bacteria,COG2908@2|Bacteria,1QQ8F@1224|Proteobacteria,42PWF@68525|delta/epsilon subdivisions,2WKVA@28221|Deltaproteobacteria,2YYIQ@29|Myxococcales 28221|Deltaproteobacteria E GMC oxidoreductase choD - 1.1.3.6 ko:K03333 ko00984,ko01120,map00984,map01120 - R01459 RC00146 ko00000,ko00001,ko01000 - - - GMC_oxred_C,GMC_oxred_N k59_849221_1 436308.Nmar_1597 2.03e-118 349.0 COG0043@1|root,arCOG01671@2157|Archaea,41SEQ@651137|Thaumarchaeota 651137|Thaumarchaeota H UbiD family decarboxylase - - - - - - - - - - - - UbiD k59_1696609_1 7029.ACYPI065480-PA 2.26e-66 208.0 2E6PU@1|root,2SDCQ@2759|Eukaryota,3ABW1@33154|Opisthokonta,3BVKN@33208|Metazoa,3DJX5@33213|Bilateria,4239J@6656|Arthropoda 33208|Metazoa - - - - - - - - - - - - - - - k59_114967_2 1454010.JEOE01000032_gene2889 1.12e-22 94.0 COG0748@1|root,COG0748@2|Bacteria,2IFYD@201174|Actinobacteria 201174|Actinobacteria P F420H(2)-dependent quinone reductase - - - - - - - - - - - - F420H2_quin_red k59_1640134_2 1451261.AS96_04925 4.82e-05 47.4 COG0697@1|root,COG0697@2|Bacteria,2GK49@201174|Actinobacteria,4FP0C@85023|Microbacteriaceae 201174|Actinobacteria EG EamA-like transporter family cyeA - - - - - - - - - - - EamA k59_1470758_1 1250232.JQNJ01000001_gene1882 6.55e-92 281.0 COG0738@1|root,COG0738@2|Bacteria,4NEYR@976|Bacteroidetes,1HY8N@117743|Flavobacteriia 976|Bacteroidetes G Transporter fucP - - ko:K02429 - - - - ko00000,ko02000 2.A.1.7 - - MFS_1 k59_397378_2 987059.RBXJA2T_15922 1.08e-23 97.8 COG1704@1|root,COG1704@2|Bacteria,1REQE@1224|Proteobacteria 1224|Proteobacteria S LemA Family - - - ko:K03744 - - - - ko00000 - - - LemA k59_1753034_1 1392490.JHZX01000001_gene1727 4.14e-121 352.0 COG0589@1|root,COG0589@2|Bacteria,4NIWH@976|Bacteroidetes,1HXPX@117743|Flavobacteriia 976|Bacteroidetes T Universal stress protein - - - - - - - - - - - - Usp k59_114973_1 667014.Thein_0694 1.04e-111 333.0 COG1186@1|root,COG1186@2|Bacteria,2GGX5@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria J Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA prfB - - ko:K02836 - - - - ko00000,ko03012 - - - PCRF,RF-1 k59_905535_1 396588.Tgr7_2764 8.72e-75 238.0 COG0006@1|root,COG0006@2|Bacteria,1MUZS@1224|Proteobacteria,1RN0W@1236|Gammaproteobacteria,1WWJH@135613|Chromatiales 135613|Chromatiales E peptidase M24B, X-Pro dipeptidase aminopeptidase - - 3.4.11.9 ko:K01262 - - - - ko00000,ko01000,ko01002 - - - AMP_N,Peptidase_M24 k59_340938_1 717606.PaecuDRAFT_4732 6.79e-32 127.0 COG1409@1|root,COG1409@2|Bacteria,1VTEB@1239|Firmicutes 1239|Firmicutes S Calcineurin-like phosphoesterase - - - - - - - - - - - - Metallophos k59_1131686_1 1353276.JADR01000003_gene2675 4.7e-26 104.0 COG3508@1|root,COG3508@2|Bacteria,4NEYZ@976|Bacteroidetes,1HYHK@117743|Flavobacteriia 976|Bacteroidetes Q homogentisate 12-dioxygenase hmgA - 1.13.11.5 ko:K00451 ko00350,ko00643,ko01100,ko01120,map00350,map00643,map01100,map01120 M00044 R02519 RC00737 ko00000,ko00001,ko00002,ko01000 - - - HgmA k59_1131686_2 504487.JCM19302_3874 7.53e-41 137.0 2B6Y4@1|root,31ZY6@2|Bacteria,4NQUG@976|Bacteroidetes,1I3FK@117743|Flavobacteriia 976|Bacteroidetes J 23S rRNA-intervening sequence protein - - - - - - - - - - - - 23S_rRNA_IVP k59_1131686_3 1122226.AUHX01000007_gene2740 2.65e-139 401.0 COG3185@1|root,COG3185@2|Bacteria,4NFI7@976|Bacteroidetes,1HWZ3@117743|Flavobacteriia 976|Bacteroidetes E 4-hydroxyphenylpyruvate dioxygenase hppD - 1.13.11.27 ko:K00457 ko00130,ko00350,ko00360,ko01100,map00130,map00350,map00360,map01100 M00044 R01372,R02521 RC00505,RC00738 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Glyoxalase,Glyoxalase_5 k59_1414178_1 83406.HDN1F_21210 8.42e-12 65.9 COG1051@1|root,COG1051@2|Bacteria,1QUPQ@1224|Proteobacteria,1S69K@1236|Gammaproteobacteria,1J76I@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria F COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes - - - - - - - - - - - - NUDIX k59_1414178_2 1206739.BAGJ01000273_gene4050 4.13e-148 435.0 COG0318@1|root,COG0318@2|Bacteria,2GIUC@201174|Actinobacteria,4FU5M@85025|Nocardiaceae 201174|Actinobacteria IQ synthetase - - - - - - - - - - - - AMP-binding,AMP-binding_C k59_962233_1 323261.Noc_2527 1.86e-53 190.0 COG0209@1|root,COG1372@1|root,COG0209@2|Bacteria,COG1372@2|Bacteria,1MUJ8@1224|Proteobacteria,1RMPV@1236|Gammaproteobacteria,1WW6H@135613|Chromatiales 135613|Chromatiales F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides - - 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - ATP-cone,LAGLIDADG_3,Ribonuc_red_lgC,Ribonuc_red_lgN k59_1761_1 1521187.JPIM01000003_gene3021 4.88e-65 221.0 COG1472@1|root,COG1472@2|Bacteria,2G639@200795|Chloroflexi,374XN@32061|Chloroflexia 32061|Chloroflexia G Belongs to the glycosyl hydrolase 3 family - - 3.2.1.21 ko:K05349 ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110 - R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040 RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248 ko00000,ko00001,ko01000 - GH3 - Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C,PA14 k59_340951_1 555079.Toce_0906 3.67e-31 120.0 COG1420@1|root,COG1420@2|Bacteria,1TQP7@1239|Firmicutes,247K2@186801|Clostridia,42F85@68295|Thermoanaerobacterales 186801|Clostridia K Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons hrcA - - ko:K03705 - - - - ko00000,ko03000 - - - HrcA,HrcA_DNA-bdg k59_1131693_1 436308.Nmar_1653 1.48e-131 378.0 COG1108@1|root,arCOG01006@2157|Archaea,41SG2@651137|Thaumarchaeota 651137|Thaumarchaeota P ABC 3 transport family - - - ko:K09816 ko02010,map02010 M00242 - - ko00000,ko00001,ko00002,ko02000 3.A.1.15.3,3.A.1.15.5 - - ABC-3 k59_227713_2 877424.ATWC01000022_gene2507 6.15e-12 72.0 COG4641@1|root,COG4641@2|Bacteria,1TS28@1239|Firmicutes,24E2J@186801|Clostridia,27T93@186928|unclassified Lachnospiraceae 186801|Clostridia S DUF based on E. rectale Gene description (DUF3880) - - - ko:K06320 - - - - ko00000 - - - DUF3880,Glyco_trans_1_2 k59_1019029_2 1221522.B723_12110 7.85e-23 98.6 COG0406@1|root,COG0406@2|Bacteria,1N677@1224|Proteobacteria,1S77A@1236|Gammaproteobacteria,1YQCT@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria G Phosphoglycerate mutase family - - - - - - - - - - - - His_Phos_1 k59_1640166_1 550540.Fbal_1463 2.84e-108 334.0 COG0376@1|root,COG0376@2|Bacteria,1MUBF@1224|Proteobacteria,1RNA5@1236|Gammaproteobacteria 1236|Gammaproteobacteria P Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity katG GO:0000302,GO:0003674,GO:0003824,GO:0004096,GO:0004601,GO:0005488,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009636,GO:0009987,GO:0010035,GO:0016209,GO:0016491,GO:0016684,GO:0016999,GO:0017001,GO:0017144,GO:0020037,GO:0033554,GO:0034599,GO:0034614,GO:0035690,GO:0042221,GO:0042493,GO:0042542,GO:0042737,GO:0042743,GO:0042744,GO:0044237,GO:0044248,GO:0044424,GO:0044444,GO:0044464,GO:0046677,GO:0046906,GO:0048037,GO:0050896,GO:0051186,GO:0051187,GO:0051716,GO:0055114,GO:0070301,GO:0070887,GO:0071236,GO:0072593,GO:0097159,GO:0097237,GO:0098754,GO:0098869,GO:1901363,GO:1901700,GO:1901701,GO:1990748 1.11.1.21 ko:K03782 ko00360,ko00380,ko00940,ko00983,ko01100,ko01110,map00360,map00380,map00940,map00983,map01100,map01110 - R00602,R00698,R02596,R02670,R03919,R04007,R07443,R11906 RC00034,RC00213,RC00767,RC02141 ko00000,ko00001,ko01000 - - - peroxidase k59_227721_1 323261.Noc_2788 1.59e-109 326.0 COG0517@1|root,COG0794@1|root,COG0517@2|Bacteria,COG0794@2|Bacteria,1MUXD@1224|Proteobacteria,1RMT9@1236|Gammaproteobacteria,1WWFJ@135613|Chromatiales 135613|Chromatiales M Arabinose 5-phosphate isomerase - - 5.3.1.13 ko:K06041 ko00540,ko01100,map00540,map01100 M00063 R01530 RC00541 ko00000,ko00001,ko00002,ko01000,ko01005 - - - CBS,SIS k59_227721_2 1121035.AUCH01000003_gene1206 5.74e-08 53.1 COG1778@1|root,COG1778@2|Bacteria,1RH85@1224|Proteobacteria,2VRQX@28216|Betaproteobacteria,2KWGX@206389|Rhodocyclales 206389|Rhodocyclales S 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase, YrbI family - - 3.1.3.45 ko:K03270 ko00540,ko01100,map00540,map01100 M00063 R03350 RC00017 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Hydrolase_3 k59_171579_1 1229909.NSED_02715 7.17e-46 153.0 arCOG08683@1|root,arCOG08683@2157|Archaea,41SUM@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1527212_1 926567.TheveDRAFT_0050 8.67e-34 128.0 COG1083@1|root,COG1083@2|Bacteria,3TC5U@508458|Synergistetes 508458|Synergistetes M Cytidylyltransferase - - - - - - - - - - - - CTP_transf_3 k59_1301398_1 754476.Q7A_2762 6.53e-62 194.0 COG1272@1|root,COG1272@2|Bacteria,1PGRH@1224|Proteobacteria,1RR4R@1236|Gammaproteobacteria,4610P@72273|Thiotrichales 72273|Thiotrichales S Haemolysin-III related - - - ko:K11068 - - - - ko00000,ko02042 - - - HlyIII k59_1244849_1 1122137.AQXF01000001_gene2642 1.49e-146 422.0 COG1960@1|root,COG1960@2|Bacteria,1MVJC@1224|Proteobacteria,2TQRA@28211|Alphaproteobacteria 28211|Alphaproteobacteria I acyl-CoA dehydrogenase - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_1019041_1 745718.JADT01000017_gene1097 5.09e-56 188.0 COG5000@1|root,COG5000@2|Bacteria,4PKJN@976|Bacteroidetes,1IJB1@117743|Flavobacteriia 976|Bacteroidetes T Signal Transduction Histidine Kinase - - - - - - - - - - - - HATPase_c,HisKA k59_1075007_1 765910.MARPU_00135 3.17e-05 45.4 COG0448@1|root,COG0448@2|Bacteria,1MVTC@1224|Proteobacteria,1RP04@1236|Gammaproteobacteria,1WW77@135613|Chromatiales 135613|Chromatiales H Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans glgC - 2.7.7.27 ko:K00975 ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026 M00565 R00948 RC00002 ko00000,ko00001,ko00002,ko01000 - - - Hexapep,NTP_transferase k59_1075007_2 1265313.HRUBRA_02888 3.7e-23 100.0 COG0297@1|root,COG0297@2|Bacteria,1MUGM@1224|Proteobacteria,1RNMP@1236|Gammaproteobacteria,1J895@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria G Starch synthase catalytic domain glgA GO:0000271,GO:0003674,GO:0003824,GO:0004373,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0006073,GO:0006091,GO:0006112,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008194,GO:0009011,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0015980,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033554,GO:0033692,GO:0034637,GO:0034645,GO:0035251,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0046527,GO:0050896,GO:0051716,GO:0055114,GO:0071704,GO:1901576 2.4.1.21 ko:K00703 ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026 M00565 R02421 RC00005 ko00000,ko00001,ko00002,ko01000,ko01003 - GT5 iSFV_1184.SFV_3438 Glyco_transf_5,Glycos_transf_1 k59_1357783_1 267608.RSc1889 1.43e-64 219.0 COG1529@1|root,COG1529@2|Bacteria,1QTTJ@1224|Proteobacteria,2VHB9@28216|Betaproteobacteria,1JZMH@119060|Burkholderiaceae 28216|Betaproteobacteria C PFAM aldehyde oxidase and xanthine dehydrogenase molybdopterin binding iorB2 - 1.3.99.16 ko:K07303 - - - - ko00000,ko01000 - - - Ald_Xan_dh_C2 k59_1244863_1 1144305.PMI02_00158 7.19e-80 244.0 COG1024@1|root,COG1024@2|Bacteria,1Q51H@1224|Proteobacteria,2TUPH@28211|Alphaproteobacteria,2K2FJ@204457|Sphingomonadales 204457|Sphingomonadales I Enoyl-CoA hydratase isomerase - - 4.2.1.17 ko:K01692 ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212 M00032,M00087 R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093 RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 - - - ECH_1 k59_1301402_1 1380355.JNIJ01000006_gene3041 1.21e-59 196.0 COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,2TQTP@28211|Alphaproteobacteria,3JR1M@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria L PFAM transposase IS116 IS110 IS902 family - - - ko:K07486 - - - - ko00000 - - - DEDD_Tnp_IS110,Transposase_20 k59_1188250_2 694427.Palpr_0341 6e-13 70.1 COG1472@1|root,COG1472@2|Bacteria,4NE90@976|Bacteroidetes,2FMV4@200643|Bacteroidia,22XDH@171551|Porphyromonadaceae 976|Bacteroidetes G Fibronectin type III-like domain - - 3.2.1.21 ko:K05349 ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110 - R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040 RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248 ko00000,ko00001,ko01000 - GH3 - Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C,PA14 k59_1357795_1 1279017.AQYJ01000028_gene2502 4.88e-58 189.0 COG0576@1|root,COG0576@2|Bacteria,1RH8T@1224|Proteobacteria,1S5W5@1236|Gammaproteobacteria,467BX@72275|Alteromonadaceae 1236|Gammaproteobacteria O Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ grpE GO:0000166,GO:0000774,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006950,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0016043,GO:0017076,GO:0019904,GO:0022607,GO:0030234,GO:0030554,GO:0032991,GO:0036094,GO:0042802,GO:0042803,GO:0043933,GO:0044085,GO:0044424,GO:0044444,GO:0044464,GO:0046983,GO:0050790,GO:0050896,GO:0051082,GO:0060589,GO:0060590,GO:0065003,GO:0065007,GO:0065009,GO:0071840,GO:0097159,GO:0098772,GO:1901265,GO:1901363 - ko:K03687 - - - - ko00000,ko03029,ko03110 - - - GrpE k59_1696666_1 702113.PP1Y_AT18847 1.76e-92 285.0 COG0433@1|root,COG0433@2|Bacteria,1MUSH@1224|Proteobacteria,2TUN9@28211|Alphaproteobacteria,2K091@204457|Sphingomonadales 204457|Sphingomonadales S Domain of unknown function DUF87 - - - ko:K06915 - - - - ko00000 - - - DUF853,DUF87 k59_1696668_1 203122.Sde_2381 1.14e-20 95.9 COG1199@1|root,COG1199@2|Bacteria,1MVCU@1224|Proteobacteria,1RMNX@1236|Gammaproteobacteria,465XA@72275|Alteromonadaceae 1236|Gammaproteobacteria KL COG1199 Rad3-related DNA helicases dinG - 3.6.4.12 ko:K03722 - - - - ko00000,ko01000,ko03400 - - - DEAD,DEAD_2,Helicase_C_2,ResIII k59_1527231_1 378806.STAUR_6532 4.04e-41 139.0 COG0346@1|root,COG0346@2|Bacteria,1N3K0@1224|Proteobacteria,43CC1@68525|delta/epsilon subdivisions,2X7MW@28221|Deltaproteobacteria,2Z0EM@29|Myxococcales 28221|Deltaproteobacteria E Glyoxalase-like domain - - - - - - - - - - - - - k59_1527231_2 1415778.JQMM01000001_gene55 1.59e-50 179.0 COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,1RPCU@1236|Gammaproteobacteria,1J4ET@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S COG0488 ATPase components of ABC transporters with duplicated ATPase domains uup GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0008150,GO:0009314,GO:0009628,GO:0010528,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019219,GO:0019222,GO:0031323,GO:0044424,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051171,GO:0060255,GO:0065007,GO:0070894,GO:0071944,GO:0080090,GO:0097159,GO:1901363 - ko:K15738 - - - - ko00000,ko02000 3.A.1.120.6 - - ABC_tran,ABC_tran_CTD,ABC_tran_Xtn k59_1244890_1 1122137.AQXF01000001_gene2790 6.69e-94 280.0 COG0861@1|root,COG0861@2|Bacteria,1MWC9@1224|Proteobacteria,2TTT6@28211|Alphaproteobacteria 28211|Alphaproteobacteria P membrane protein TerC terC - - - - - - - - - - - TerC k59_1244890_2 1122137.AQXF01000001_gene2789 1.05e-67 211.0 COG0745@1|root,COG0745@2|Bacteria,1NSPI@1224|Proteobacteria,2TYPT@28211|Alphaproteobacteria 28211|Alphaproteobacteria T cheY-homologous receiver domain - - - - - - - - - - - - Response_reg k59_1244890_3 1122137.AQXF01000001_gene2788 2.33e-20 89.0 COG0060@1|root,COG0060@2|Bacteria,1MVBQ@1224|Proteobacteria,2TR3N@28211|Alphaproteobacteria 28211|Alphaproteobacteria J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) ileS - 6.1.1.5 ko:K01870 ko00970,map00970 M00359,M00360 R03656 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,tRNA-synt_1,zf-FPG_IleRS k59_1188270_1 1120949.KB903358_gene5276 1.69e-41 146.0 COG1028@1|root,COG1028@2|Bacteria,2GIYQ@201174|Actinobacteria,4DBTB@85008|Micromonosporales 201174|Actinobacteria IQ Belongs to the short-chain dehydrogenases reductases (SDR) family - - - - - - - - - - - - adh_short k59_510264_1 1122137.AQXF01000002_gene160 6.07e-117 349.0 COG0504@1|root,COG0504@2|Bacteria,1MUIT@1224|Proteobacteria,2TS4Y@28211|Alphaproteobacteria 28211|Alphaproteobacteria F Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates pyrG - 6.3.4.2 ko:K01937 ko00240,ko01100,map00240,map01100 M00052 R00571,R00573 RC00010,RC00074 ko00000,ko00001,ko00002,ko01000 - - - CTP_synth_N,GATase k59_115083_1 1097668.BYI23_C012310 1.33e-150 436.0 COG3119@1|root,COG3119@2|Bacteria,1MUJH@1224|Proteobacteria,2VNDQ@28216|Betaproteobacteria,1K60X@119060|Burkholderiaceae 28216|Betaproteobacteria P Sulfatase - - 3.1.6.1,3.1.6.6 ko:K01130,ko:K01133 ko00140,ko00600,map00140,map00600 - R03980,R04856 RC00128,RC00231 ko00000,ko00001,ko01000 - - - Sulfatase,Sulfatase_C k59_58574_1 436308.Nmar_0701 8.35e-94 291.0 COG0365@1|root,arCOG04201@2157|Archaea 2157|Archaea I COG0365 Acyl-coenzyme A synthetases AMP-(fatty) acid ligases acsA - 6.2.1.1 ko:K01895 ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200 M00357 R00235,R00236,R00316,R00926,R01354 RC00004,RC00012,RC00043,RC00070,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000,ko01004 - - - ACAS_N,AMP-binding,AMP-binding_C k59_1583613_1 555793.WSK_0730 1.45e-132 389.0 COG0195@1|root,COG0195@2|Bacteria,1MWT7@1224|Proteobacteria,2TRQN@28211|Alphaproteobacteria,2K1KF@204457|Sphingomonadales 204457|Sphingomonadales K Participates in both transcription termination and antitermination nusA - - ko:K02600 - - - - ko00000,ko03009,ko03021 - - - HHH_5,KH_5,NusA_N,S1 k59_1753131_1 396588.Tgr7_0009 2.65e-05 45.4 COG1192@1|root,COG1192@2|Bacteria,1QBJX@1224|Proteobacteria,1S27K@1236|Gammaproteobacteria 1236|Gammaproteobacteria D VirC1 protein - - - ko:K03496 - - - - ko00000,ko03036,ko04812 - - - AAA_31,CbiA,MipZ k59_1753131_2 519989.ECTPHS_07511 6.49e-31 124.0 COG3071@1|root,COG3071@2|Bacteria,1MU7A@1224|Proteobacteria,1RMRG@1236|Gammaproteobacteria,1X0CU@135613|Chromatiales 135613|Chromatiales H HemY domain protein - - - ko:K02498 - - - - ko00000 - - - HemY_N k59_341043_1 360104.CCC13826_0071 1.63e-52 183.0 COG0342@1|root,COG0342@2|Bacteria,1MV5U@1224|Proteobacteria,42M6V@68525|delta/epsilon subdivisions,2YM9I@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA secD - - ko:K03072 ko03060,ko03070,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 2.A.6.4,3.A.5.2,3.A.5.7 - - SecD_SecF,Sec_GG k59_1244902_1 244582.JQAK01000001_gene1511 4.98e-29 115.0 COG2211@1|root,COG2211@2|Bacteria,1QTSE@1224|Proteobacteria,2TWGV@28211|Alphaproteobacteria,47GTJ@766|Rickettsiales 766|Rickettsiales G COG0477 Permeases of the major facilitator superfamily ampG4 - - ko:K08218 ko01501,map01501 M00628 - - ko00000,ko00001,ko00002,ko02000 2.A.1.25 - - MFS_1 k59_1640243_1 1265313.HRUBRA_02474 9.03e-87 259.0 COG0094@1|root,COG0094@2|Bacteria,1MUU9@1224|Proteobacteria,1RPE1@1236|Gammaproteobacteria,1J50H@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits rplE GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02931 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L5,Ribosomal_L5_C k59_1640243_2 887898.HMPREF0551_1896 9.97e-40 134.0 COG0198@1|root,COG0198@2|Bacteria,1MZQD@1224|Proteobacteria,2VUC6@28216|Betaproteobacteria,1K8C0@119060|Burkholderiaceae 28216|Betaproteobacteria J One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit rplX - - ko:K02895 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - KOW,ribosomal_L24 k59_1414248_2 637905.SVI_0871 8.43e-47 167.0 COG3291@1|root,COG5297@1|root,COG3291@2|Bacteria,COG5297@2|Bacteria,1R47A@1224|Proteobacteria,1RREU@1236|Gammaproteobacteria 1236|Gammaproteobacteria G Belongs to the glycosyl hydrolase family 6 cel6A - 3.2.1.91 ko:K19668 ko00500,ko01100,ko02020,map00500,map01100,map02020 - R02886,R11308 RC00799 ko00000,ko00001,ko01000 - GH6 - CBM_10,CBM_2,Glyco_hydro_6,PKD k59_1357830_1 926569.ANT_06600 1.8e-44 165.0 COG2203@1|root,COG5002@1|root,COG2203@2|Bacteria,COG5002@2|Bacteria,2G7NF@200795|Chloroflexi 200795|Chloroflexi T histidine kinase A domain protein - - - - - - - - - - - - GAF_2,HATPase_c,HisKA k59_453755_1 880070.Cycma_4553 8.37e-58 194.0 COG0493@1|root,COG1144@1|root,COG0493@2|Bacteria,COG1144@2|Bacteria,4NM18@976|Bacteroidetes,47XKA@768503|Cytophagia 976|Bacteroidetes C Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster - - - - - - - - - - - - Fer4_20,Pyr_redox_2 k59_1696686_1 247633.GP2143_10672 1.55e-39 143.0 2CIBN@1|root,2Z8JT@2|Bacteria,1R902@1224|Proteobacteria,1RXPM@1236|Gammaproteobacteria,1J8X1@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Metal dependent phosphohydrolases with conserved 'HD' motif. - - - - - - - - - - - - - k59_1836_1 457398.HMPREF0326_01802 1.66e-62 202.0 COG3177@1|root,COG3177@2|Bacteria,1MWAU@1224|Proteobacteria,42PWW@68525|delta/epsilon subdivisions,2WJM6@28221|Deltaproteobacteria 28221|Deltaproteobacteria S PFAM filamentation induced by cAMP protein Fic - - - - - - - - - - - - Fic k59_1301452_2 522373.Smlt1130 1.12e-13 72.0 COG1208@1|root,COG1208@2|Bacteria,1R9ZD@1224|Proteobacteria,1S23A@1236|Gammaproteobacteria,1X37W@135614|Xanthomonadales 135614|Xanthomonadales JM Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits (eIF-2Bgamma eIF-2Bepsilon) - - 2.7.7.99 ko:K00992 ko00520,ko01100,map00520,map01100 - R11025 RC00002 ko00000,ko00001,ko01000 - - - NTP_transferase k59_962345_1 702113.PP1Y_Mpl2082 1.17e-51 177.0 COG0668@1|root,COG0668@2|Bacteria,1QATN@1224|Proteobacteria,2UUYU@28211|Alphaproteobacteria 28211|Alphaproteobacteria M Mechanosensitive ion channel - - - - - - - - - - - - MS_channel k59_962345_2 1121438.JNJA01000031_gene1910 5.35e-144 428.0 COG3968@1|root,COG3968@2|Bacteria,1QUKF@1224|Proteobacteria,42PBH@68525|delta/epsilon subdivisions,2WJZG@28221|Deltaproteobacteria,2M9AA@213115|Desulfovibrionales 28221|Deltaproteobacteria S Glutamine synthetase, catalytic region glnN - 6.3.1.2 ko:K01915 ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 - R00253 RC00010,RC02798 ko00000,ko00001,ko01000,ko04147 - - - GSIII_N,Gln-synt_C k59_1188297_1 1288494.EBAPG3_26480 1.21e-118 344.0 COG0036@1|root,COG0036@2|Bacteria,1MUZM@1224|Proteobacteria,2VIGU@28216|Betaproteobacteria,371Y4@32003|Nitrosomonadales 28216|Betaproteobacteria G Belongs to the ribulose-phosphate 3-epimerase family rpe - 5.1.3.1 ko:K01783 ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007 R01529 RC00540 ko00000,ko00001,ko00002,ko01000 - - - Ribul_P_3_epim k59_171650_1 1248760.ANFZ01000005_gene2234 4.71e-62 195.0 COG0835@1|root,COG0835@2|Bacteria,1RETU@1224|Proteobacteria,2U87V@28211|Alphaproteobacteria,2K4XN@204457|Sphingomonadales 204457|Sphingomonadales NT Two component signalling adaptor domain - - - ko:K03408 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - CheW k59_510314_1 96561.Dole_1132 4.47e-76 241.0 COG0001@1|root,COG0001@2|Bacteria,1MUY5@1224|Proteobacteria,42Y9H@68525|delta/epsilon subdivisions,2WUPN@28221|Deltaproteobacteria,2MN1Q@213118|Desulfobacterales 28221|Deltaproteobacteria H Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family - - 5.4.3.8 ko:K01845 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R02272 RC00677 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 k59_1026552_1 97139.C824_04499 8.03e-63 199.0 COG0231@1|root,COG0231@2|Bacteria,1TR8P@1239|Firmicutes,249DV@186801|Clostridia,36DS4@31979|Clostridiaceae 186801|Clostridia J Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase efp - - ko:K02356 - - - - ko00000,ko03012 - - - EFP,EFP_N,Elong-fact-P_C k59_348362_1 926569.ANT_07480 2.26e-62 202.0 COG0715@1|root,COG0715@2|Bacteria,2G6E9@200795|Chloroflexi 200795|Chloroflexi P PFAM NMT1 THI5 like domain protein - - - ko:K02051 - M00188 - - ko00000,ko00002,ko02000 3.A.1.16,3.A.1.17 - - NMT1 k59_969089_1 1122137.AQXF01000001_gene2607 1.45e-136 407.0 COG1629@1|root,COG4771@2|Bacteria,1MVFB@1224|Proteobacteria,2U2KS@28211|Alphaproteobacteria 28211|Alphaproteobacteria P TonB-dependent receptor plug - - - - - - - - - - - - Plug,TonB_dep_Rec k59_1082364_2 1415778.JQMM01000001_gene1551 5.44e-63 198.0 COG2518@1|root,COG2518@2|Bacteria,1MXQC@1224|Proteobacteria,1RMHZ@1236|Gammaproteobacteria,1J5GV@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins pcm GO:0003674,GO:0003824,GO:0004719,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006479,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0010340,GO:0016740,GO:0016741,GO:0019538,GO:0030091,GO:0032259,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0051998,GO:0071704,GO:0140096,GO:1901564 2.1.1.77 ko:K00573 - - - - ko00000,ko01000 - - - PCMT k59_743494_1 1476583.DEIPH_ctg050orf0028 2.53e-35 126.0 COG1490@1|root,COG1490@2|Bacteria,1WJUX@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus J rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality dtd GO:0002161,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006399,GO:0006450,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0034641,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0051499,GO:0051500,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360 - ko:K07560 - - - - ko00000,ko01000,ko03016 - - - Tyr_Deacylase k59_743494_2 1380387.JADM01000002_gene2189 7.74e-29 108.0 COG0131@1|root,COG0131@2|Bacteria,1MWBS@1224|Proteobacteria,1RPA9@1236|Gammaproteobacteria,1XIRE@135619|Oceanospirillales 135619|Oceanospirillales E Imidazoleglycerol-phosphate dehydratase hisB - 4.2.1.19 ko:K01693 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R03457 RC00932 ko00000,ko00001,ko00002,ko01000 - - - IGPD k59_1760179_1 1096930.L284_05555 3.89e-105 312.0 COG1868@1|root,COG1868@2|Bacteria,1MX01@1224|Proteobacteria,2TR4F@28211|Alphaproteobacteria,2K0TZ@204457|Sphingomonadales 204457|Sphingomonadales N FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation fliM - - ko:K02416 ko02030,ko02040,map02030,map02040 - - - ko00000,ko00001,ko02035 - - - FliM,FliMN_C k59_122367_1 1144305.PMI02_04990 8.2e-203 602.0 COG0085@1|root,COG0085@2|Bacteria,1MUC4@1224|Proteobacteria,2TS7S@28211|Alphaproteobacteria,2JZWE@204457|Sphingomonadales 204457|Sphingomonadales K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoB - 2.7.7.6 ko:K03043 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7 k59_969103_1 400668.Mmwyl1_3925 6.81e-24 101.0 COG0511@1|root,COG5016@1|root,COG0511@2|Bacteria,COG5016@2|Bacteria,1QTTG@1224|Proteobacteria,1RNG6@1236|Gammaproteobacteria,1XH46@135619|Oceanospirillales 135619|Oceanospirillales CI Catalyzes the formation of oxaloacetate from pyruvate - - 6.4.1.1 ko:K01960 ko00020,ko00620,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00720,map01100,map01120,map01200,map01230 M00173,M00620 R00344 RC00040,RC00367 ko00000,ko00001,ko00002,ko01000 - - - Biotin_lipoyl,HMGL-like,PYC_OADA k59_969103_2 1121374.KB891575_gene1361 1.59e-16 75.9 COG0288@1|root,COG0288@2|Bacteria,1MV1U@1224|Proteobacteria,1SYDI@1236|Gammaproteobacteria 1236|Gammaproteobacteria P Reversible hydration of carbon dioxide cynT GO:0003674,GO:0003824,GO:0004089,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009056,GO:0009439,GO:0009440,GO:0009987,GO:0016829,GO:0016835,GO:0016836,GO:0034641,GO:0042802,GO:0043167,GO:0043169,GO:0044237,GO:0044248,GO:0044270,GO:0044281,GO:0044424,GO:0044464,GO:0046872,GO:0046914,GO:0071704,GO:1901564,GO:1901565,GO:1901575 4.2.1.1 ko:K01673 ko00910,map00910 - R00132,R10092 RC02807 ko00000,ko00001,ko01000 - - iJN746.PP_0100 Pro_CA k59_743511_1 1144305.PMI02_01702 4.01e-49 165.0 COG1028@1|root,COG1028@2|Bacteria,1MWSK@1224|Proteobacteria,2U7J0@28211|Alphaproteobacteria,2K4Z5@204457|Sphingomonadales 204457|Sphingomonadales IQ overlaps another CDS with the same product name - - - - - - - - - - - - adh_short_C2 k59_1308483_2 1469245.JFBG01000023_gene1276 2.04e-85 263.0 COG0644@1|root,COG0644@2|Bacteria,1MXQY@1224|Proteobacteria,1SEJ8@1236|Gammaproteobacteria 1236|Gammaproteobacteria C geranylgeranyl reductase - - - - - - - - - - - - FAD_binding_3 k59_292058_1 1122137.AQXF01000001_gene2865 7.82e-110 319.0 COG2884@1|root,COG2884@2|Bacteria,1MVQ4@1224|Proteobacteria,2TS9Y@28211|Alphaproteobacteria 28211|Alphaproteobacteria D cell division ATP-binding protein FtsE ftsE - - ko:K09812 ko02010,map02010 M00256 - - ko00000,ko00001,ko00002,ko02000,ko03036 3.A.1.140 - - ABC_tran k59_1760195_2 1120705.FG95_00714 1.18e-92 296.0 COG4774@1|root,COG4774@2|Bacteria,1NMCN@1224|Proteobacteria,2U0J1@28211|Alphaproteobacteria,2K2U9@204457|Sphingomonadales 204457|Sphingomonadales P TonB dependent receptor - - - - - - - - - - - - Plug,TonB_dep_Rec k59_856808_1 1346791.M529_19605 1.88e-83 265.0 COG0457@1|root,COG0457@2|Bacteria,1QUU4@1224|Proteobacteria,2TW7Q@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Tetratricopeptide repeat - - - - - - - - - - - - DUF4071 k59_1534494_1 1122164.JHWF01000007_gene1094 6.05e-24 105.0 COG0210@1|root,COG2887@1|root,COG0210@2|Bacteria,COG2887@2|Bacteria,1QVX1@1224|Proteobacteria,1RP9I@1236|Gammaproteobacteria,1JD1Q@118969|Legionellales 118969|Legionellales L PD-(D/E)XK nuclease superfamily lidB - - - - - - - - - - - PDDEXK_1 k59_1478304_1 760117.JN27_02260 5.62e-73 230.0 COG0451@1|root,COG0451@2|Bacteria,1MWVJ@1224|Proteobacteria,2VJ3T@28216|Betaproteobacteria,473J1@75682|Oxalobacteraceae 28216|Betaproteobacteria GM RmlD substrate binding domain yeeZ - - - - - - - - - - - Epimerase,NAD_binding_10,RmlD_sub_bind,TrkA_N k59_1703553_1 161156.JQKW01000001_gene1454 4.61e-26 100.0 COG0636@1|root,COG0636@2|Bacteria,2GHXH@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria P F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation atpE - - ko:K02110 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt_C k59_1703553_2 1121405.dsmv_0363 4.63e-13 67.0 COG0356@1|root,COG0356@2|Bacteria,1MV87@1224|Proteobacteria,42NR9@68525|delta/epsilon subdivisions,2WKX1@28221|Deltaproteobacteria,2MHZU@213118|Desulfobacterales 28221|Deltaproteobacteria C it plays a direct role in the translocation of protons across the membrane atpB - - ko:K02108 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko03110 3.A.2.1 - - ATP-synt_A k59_178329_1 911045.PSE_0300 9.39e-86 275.0 COG0445@1|root,COG0445@2|Bacteria,1MU6F@1224|Proteobacteria,2TRJS@28211|Alphaproteobacteria 28211|Alphaproteobacteria D NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 gidA GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901363 - ko:K03495 - - R08701 RC00053,RC00209,RC00870 ko00000,ko03016,ko03036 - - - GIDA,GIDA_assoc k59_178329_2 536233.CLO_0103 4.48e-08 57.0 COG0357@1|root,COG0357@2|Bacteria,1TPBT@1239|Firmicutes,247WM@186801|Clostridia,36EMZ@31979|Clostridiaceae 186801|Clostridia J Specifically methylates the N7 position of a guanine in 16S rRNA rsmG - 2.1.1.170 ko:K03501 - - - - ko00000,ko01000,ko03009,ko03036 - - - GidB k59_743520_1 436308.Nmar_0063 1.56e-149 432.0 COG0423@1|root,arCOG00405@2157|Archaea,41S8S@651137|Thaumarchaeota 651137|Thaumarchaeota J synthetase (class II) - - 6.1.1.14 ko:K01880 ko00970,map00970 M00359,M00360 R03654 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - HGTP_anticodon,tRNA-synt_2b k59_743520_2 436308.Nmar_0062 1e-203 572.0 COG0463@1|root,arCOG00894@2157|Archaea,41SAS@651137|Thaumarchaeota 651137|Thaumarchaeota M glycosyl transferase family 2 - - 2.4.1.83 ko:K00721 ko00510,ko01100,map00510,map01100 - R01009 RC00005 ko00000,ko00001,ko01000,ko01003 - GT2 - Glycos_transf_2,GtrA k59_743520_3 1229909.NSED_09935 7.56e-51 166.0 COG5491@1|root,arCOG00452@2157|Archaea,41SJ3@651137|Thaumarchaeota 651137|Thaumarchaeota D conserved protein implicated in secretion - - - - - - - - - - - - - k59_856815_2 1094508.Tsac_0555 2.17e-19 91.3 COG1195@1|root,COG1195@2|Bacteria,1TP9U@1239|Firmicutes,247KY@186801|Clostridia,42FFR@68295|Thermoanaerobacterales 186801|Clostridia L it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP recF - - ko:K03629 ko03440,map03440 - - - ko00000,ko00001,ko03400 - - - SMC_N k59_686700_1 1380391.JIAS01000006_gene2535 9.52e-18 78.6 COG1254@1|root,COG1254@2|Bacteria,1PU46@1224|Proteobacteria,2UF7Z@28211|Alphaproteobacteria,2JTTR@204441|Rhodospirillales 204441|Rhodospirillales C Belongs to the acylphosphatase family acyP - 3.6.1.7 ko:K01512 ko00620,ko00627,ko01120,map00620,map00627,map01120 - R00317,R01421,R01515 RC00043 ko00000,ko00001,ko01000 - - - Acylphosphatase k59_460899_1 1044.EH31_00500 4.78e-89 276.0 COG2270@1|root,COG2270@2|Bacteria,1QUNG@1224|Proteobacteria,2TTIE@28211|Alphaproteobacteria 28211|Alphaproteobacteria S COG0477 Permeases of the major facilitator superfamily - - - - - - - - - - - - MFS_1 k59_573694_1 992406.RIA_1469 3.89e-49 166.0 COG0468@1|root,COG0468@2|Bacteria,4NEXT@976|Bacteroidetes,1HY3S@117743|Flavobacteriia 976|Bacteroidetes L Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage recA - - ko:K03553 ko03440,map03440 M00729 - - ko00000,ko00001,ko00002,ko03400 - - - RecA k59_573694_2 1380600.AUYN01000007_gene3043 1.71e-06 48.1 2E32X@1|root,32Y35@2|Bacteria,4NUUU@976|Bacteroidetes,1I54Q@117743|Flavobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_1478314_1 436308.Nmar_0694 6.76e-97 284.0 COG0638@1|root,arCOG00970@2157|Archaea,41SGS@651137|Thaumarchaeota 651137|Thaumarchaeota O Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation - - 3.4.25.1 ko:K03433 ko03050,map03050 M00342,M00343 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03051 - - - Proteasome k59_1478314_2 436308.Nmar_0692 9.66e-42 148.0 COG0624@1|root,arCOG01110@2157|Archaea,41SAE@651137|Thaumarchaeota 651137|Thaumarchaeota E Peptidase dimerisation domain - - - - - - - - - - - - M20_dimer,Peptidase_M20 k59_1195239_1 511.JT27_19730 8.58e-30 122.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2VHFI@28216|Betaproteobacteria,3T1NA@506|Alcaligenaceae 28216|Betaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family bepE_2 - - ko:K18138 ko01501,ko01503,map01501,map01503 M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000 2.A.6.2 - - ACR_tran k59_234733_1 880071.Fleli_2470 1.12e-171 499.0 COG4772@1|root,COG4772@2|Bacteria,4NEUH@976|Bacteroidetes,47N13@768503|Cytophagia 976|Bacteroidetes P PFAM TonB-dependent Receptor Plug - - - - - - - - - - - - CarbopepD_reg_2,Plug,TonB_dep_Rec k59_1138697_1 999141.GME_12544 6.76e-85 277.0 COG0458@1|root,COG0458@2|Bacteria,1MUDZ@1224|Proteobacteria,1RPIU@1236|Gammaproteobacteria,1XHKH@135619|Oceanospirillales 135619|Oceanospirillales F Carbamoyl-phosphate synthetase ammonia chain carB - 6.3.5.5 ko:K01955 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - - CPSase_L_D2,CPSase_L_D3,MGS k59_1703578_1 1207063.P24_02476 5.61e-80 253.0 COG0189@1|root,COG0189@2|Bacteria,1MVUA@1224|Proteobacteria,2TQNE@28211|Alphaproteobacteria,2JPV4@204441|Rhodospirillales 204441|Rhodospirillales H Belongs to the prokaryotic GSH synthase family gshB - 6.3.2.3 ko:K01920 ko00270,ko00480,ko01100,map00270,map00480,map01100 M00118 R00497,R10994 RC00096,RC00141 ko00000,ko00001,ko00002,ko01000 - - - GSH-S_ATP,GSH-S_N k59_1703578_2 502025.Hoch_3843 7.57e-73 230.0 COG0152@1|root,COG0152@2|Bacteria,1MUR9@1224|Proteobacteria,42M8A@68525|delta/epsilon subdivisions,2WJY0@28221|Deltaproteobacteria,2YUIU@29|Myxococcales 28221|Deltaproteobacteria F Belongs to the SAICAR synthetase family purC GO:0003674,GO:0003824,GO:0004639,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006188,GO:0006189,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.2.6 ko:K01923 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04591 RC00064,RC00162 ko00000,ko00001,ko00002,ko01000 - - - SAICAR_synt k59_9450_1 595537.Varpa_1070 2.61e-15 76.6 COG2334@1|root,COG2334@2|Bacteria,1MXTW@1224|Proteobacteria,2VUCA@28216|Betaproteobacteria 28216|Betaproteobacteria S Aminoglycoside phosphotransferase - - - - - - - - - - - - APH k59_9450_2 247634.GPB2148_750 3e-19 87.8 COG0531@1|root,COG0531@2|Bacteria,1MUP1@1224|Proteobacteria,1RR0V@1236|Gammaproteobacteria 1236|Gammaproteobacteria E amino acid - - - ko:K20265 ko02024,map02024 - - - ko00000,ko00001,ko02000 2.A.3.7.1,2.A.3.7.3 - - AA_permease_2 k59_1365058_1 1122137.AQXF01000003_gene2449 2.67e-76 234.0 2DND2@1|root,32WV0@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_1365058_2 864051.BurJ1DRAFT_3820 2.29e-08 61.6 COG0583@1|root,COG0583@2|Bacteria,1N663@1224|Proteobacteria,2VH4K@28216|Betaproteobacteria,1KN6Q@119065|unclassified Burkholderiales 28216|Betaproteobacteria K LysR substrate binding domain - - - - - - - - - - - - HTH_1,LysR_substrate k59_1251967_1 926550.CLDAP_39790 2.62e-100 308.0 COG1164@1|root,COG1164@2|Bacteria,2G5JB@200795|Chloroflexi 200795|Chloroflexi E PFAM peptidase M3A and M3B, thimet oligopeptidase F - - - ko:K08602 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M3,Peptidase_M3_N k59_1082445_4 1144275.COCOR_07053 8.66e-08 52.4 2DTSQ@1|root,33MH7@2|Bacteria,1NGXY@1224|Proteobacteria,42XSM@68525|delta/epsilon subdivisions,2WSY2@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Putative zinc-finger - - - - - - - - - - - - zf-HC2 k59_1082445_5 1131269.AQVV01000031_gene283 2.54e-25 104.0 COG1595@1|root,COG1595@2|Bacteria 2|Bacteria K DNA-templated transcription, initiation - - - ko:K03088,ko:K07263 - - - - ko00000,ko01000,ko01002,ko03021 - - - Sigma70_r2,Sigma70_r4_2 k59_1251968_1 1229909.NSED_08865 5.14e-42 148.0 arCOG08791@1|root,arCOG08791@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_1420969_1 1209072.ALBT01000033_gene1729 6.46e-54 186.0 COG0171@1|root,COG0388@1|root,COG0171@2|Bacteria,COG0388@2|Bacteria,1MU9U@1224|Proteobacteria,1RNKA@1236|Gammaproteobacteria,1FGTG@10|Cellvibrio 1236|Gammaproteobacteria H Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source nadE - 6.3.1.5,6.3.5.1 ko:K01916,ko:K01950 ko00760,ko01100,map00760,map01100 M00115 R00189,R00257 RC00010,RC00100 ko00000,ko00001,ko00002,ko01000 - - - CN_hydrolase,NAD_synthase k59_348418_1 1410613.JNKF01000011_gene1141 2.74e-231 651.0 COG0366@1|root,COG0366@2|Bacteria,4NFE4@976|Bacteroidetes,2FQHN@200643|Bacteroidia 976|Bacteroidetes G Alpha amylase, catalytic domain malL - 3.2.1.1,3.2.1.10,3.2.1.20,5.4.99.16 ko:K01182,ko:K01187,ko:K05343 ko00052,ko00500,ko01100,map00052,map00500,map01100 - R00028,R00801,R00802,R01557,R01718,R01791,R02108,R02112,R06087,R06088,R06199,R11262 RC00028,RC00049,RC00059,RC00077,RC00451,RC01816 ko00000,ko00001,ko01000 - GH13,GH31 - Alpha-amylase,DUF3459,Malt_amylase_C k59_178373_1 1122137.AQXF01000002_gene114 9.41e-207 577.0 COG1894@1|root,COG1894@2|Bacteria,1MV8F@1224|Proteobacteria,2TRAH@28211|Alphaproteobacteria 28211|Alphaproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain nuoF GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 1.6.5.3 ko:K00335 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_51K,NADH_4Fe-4S,SLBB k59_178373_2 1122137.AQXF01000002_gene113 3.13e-118 340.0 COG1905@1|root,COG1905@2|Bacteria,1MWS2@1224|Proteobacteria,2TSEJ@28211|Alphaproteobacteria 28211|Alphaproteobacteria C COG1905 NADH ubiquinone oxidoreductase 24 kD subunit nuoE - 1.6.5.3,1.6.99.3 ko:K00334,ko:K03943 ko00190,ko01100,ko04714,ko04723,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map04714,map04723,map04932,map05010,map05012,map05016 M00143,M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1,3.D.1.6 - - 2Fe-2S_thioredx k59_234795_1 1415778.JQMM01000001_gene1049 3.98e-162 474.0 COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,1RQUR@1236|Gammaproteobacteria,1J54K@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria F Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen nrdZ - 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - Intein_splicing,LAGLIDADG_3,Ribonuc_red_lgC,Ribonuc_red_lgN k59_1365083_1 768671.ThimaDRAFT_0239 4.3e-163 490.0 COG1305@1|root,COG4196@1|root,COG1305@2|Bacteria,COG4196@2|Bacteria,1MVAG@1224|Proteobacteria,1RMX2@1236|Gammaproteobacteria,1WW9S@135613|Chromatiales 135613|Chromatiales E Bacterial transglutaminase-like N-terminal - - - - - - - - - - - - Bact_transglu_N,DUF2126,Transglut_core k59_292126_1 195250.CM001776_gene3424 2.59e-44 154.0 COG1189@1|root,COG1189@2|Bacteria,1G001@1117|Cyanobacteria,1GZPP@1129|Synechococcus 1117|Cyanobacteria J FtsJ-like methyltransferase tly - 2.1.1.226,2.1.1.227 ko:K06442 - - - - ko00000,ko01000,ko03009 - - - FtsJ,S4 k59_292126_2 420662.Mpe_A2631 1.47e-14 74.7 COG1154@1|root,COG1154@2|Bacteria,1MUSJ@1224|Proteobacteria,2VHXG@28216|Betaproteobacteria,1KJ7W@119065|unclassified Burkholderiales 28216|Betaproteobacteria H Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) dxs - 2.2.1.7 ko:K01662 ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130 M00096 R05636 RC00032 ko00000,ko00001,ko00002,ko01000 - - - DXP_synthase_N,Transket_pyr,Transketolase_C k59_1082472_2 314285.KT71_08440 6.77e-65 215.0 COG1053@1|root,COG1053@2|Bacteria,1MU5M@1224|Proteobacteria,1RYVY@1236|Gammaproteobacteria,1J84E@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Fumarate reductase flavoprotein C-term - - 1.3.5.4 ko:K00244 ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020 M00009,M00011,M00150,M00173 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,Succ_DH_flav_C k59_9486_1 525904.Tter_2199 9.96e-61 194.0 COG2227@1|root,COG2227@2|Bacteria,2NRF7@2323|unclassified Bacteria 2|Bacteria H Methyltransferase domain - - - - - - - - - - - - Methyltransf_11,Methyltransf_12,Methyltransf_25 k59_913020_1 326442.PSHAa2217 2.79e-44 149.0 COG2346@1|root,COG2346@2|Bacteria,1RH21@1224|Proteobacteria,1S4I5@1236|Gammaproteobacteria 1236|Gammaproteobacteria S COG2346 Truncated hemoglobins - - - ko:K06886 - - - - ko00000 - - - Bac_globin k59_460935_1 1209072.ALBT01000007_gene2793 8.91e-26 112.0 COG1020@1|root,COG1020@2|Bacteria,1QK4F@1224|Proteobacteria,1RPAG@1236|Gammaproteobacteria,1FHSS@10|Cellvibrio 1236|Gammaproteobacteria Q Condensation domain - - - - - - - - - - - - AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase k59_743572_1 1415778.JQMM01000001_gene1614 3.86e-177 500.0 COG0133@1|root,COG0133@2|Bacteria,1MUS8@1224|Proteobacteria,1RP4D@1236|Gammaproteobacteria,1J5D5@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine trpB GO:0000162,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.2.1.20 ko:K01696 ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230 M00023 R00674,R02340,R02722 RC00209,RC00210,RC00700,RC00701,RC02868 ko00000,ko00001,ko00002,ko01000 - - - PALP k59_1195289_1 1366050.N234_37755 5.02e-15 77.4 COG2271@1|root,COG2271@2|Bacteria,1P24P@1224|Proteobacteria,2VIKS@28216|Betaproteobacteria,1K0X4@119060|Burkholderiaceae 28216|Betaproteobacteria G Major facilitator superfamily MFS_1 - - - ko:K08195 - - - - ko00000,ko02000 2.A.1.15 - - MFS_1,MFS_4,Sugar_tr k59_1195289_2 627192.SLG_27940 1.55e-82 251.0 2EVK9@1|root,33P0C@2|Bacteria,1NDYB@1224|Proteobacteria,2UQHZ@28211|Alphaproteobacteria,2K9N4@204457|Sphingomonadales 204457|Sphingomonadales - - - - - - - - - - - - - - - k59_743578_2 1131266.ARWQ01000010_gene28 1.08e-18 83.6 COG1355@1|root,arCOG01728@2157|Archaea,41S9D@651137|Thaumarchaeota 651137|Thaumarchaeota S Belongs to the MEMO1 family - - - ko:K06990 - - - - ko00000,ko04812 - - - Memo k59_348429_2 1121015.N789_05050 3.76e-28 108.0 COG1234@1|root,COG1234@2|Bacteria,1R8CF@1224|Proteobacteria,1S5Z5@1236|Gammaproteobacteria,1X3V5@135614|Xanthomonadales 135614|Xanthomonadales S Metal-dependent hydrolases of the beta-lactamase superfamily III - - - - - - - - - - - - Lactamase_B_2 k59_1026667_1 991905.SL003B_3035 5.1e-101 302.0 COG3039@1|root,COG3039@2|Bacteria,1MVDK@1224|Proteobacteria,2TS7B@28211|Alphaproteobacteria,4BRM2@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria L COG3039 Transposase and inactivated derivatives, IS5 family - - - - - - - - - - - - DDE_Tnp_1,DUF772 k59_122439_1 1122214.AQWH01000026_gene4847 1.02e-55 191.0 COG2303@1|root,COG2303@2|Bacteria,1MU3F@1224|Proteobacteria,2TT3C@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Oxidoreductase - - - - - - - - - - - - FAD_binding_2,GMC_oxred_C,GMC_oxred_N,NAD_binding_8 k59_1703643_1 436308.Nmar_0517 8.36e-64 203.0 COG1405@1|root,arCOG01981@2157|Archaea,41S8Y@651137|Thaumarchaeota 651137|Thaumarchaeota K factor TFIIB - - - ko:K03124 ko03022,ko05169,ko05203,map03022,map05169,map05203 - - - ko00000,ko00001,ko03021 - - - TFIIB,TF_Zn_Ribbon k59_348437_1 377629.TERTU_0889 3.54e-201 562.0 COG0050@1|root,COG0050@2|Bacteria,1MVC0@1224|Proteobacteria,1RMYX@1236|Gammaproteobacteria,2PMSJ@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria J Elongation factor Tu GTP binding domain tuf GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - ko:K02358 - - - - ko00000,ko03012,ko03029,ko04147 - - - GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3 k59_969195_1 155864.EDL933_1947 4.88e-98 299.0 COG4166@1|root,COG4166@2|Bacteria,1P91R@1224|Proteobacteria,1RN57@1236|Gammaproteobacteria,3XMGQ@561|Escherichia 1236|Gammaproteobacteria E periplasmic oligopeptide-binding protein oppA GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0006457,GO:0006810,GO:0006857,GO:0006950,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0015833,GO:0030288,GO:0030313,GO:0031975,GO:0033218,GO:0042277,GO:0042597,GO:0042886,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0061077,GO:0071702,GO:0071705,GO:1900750 - ko:K15580 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00439 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 - iECABU_c1320.ECABU_c15240,iECNA114_1301.ECNA114_1414,iECSF_1327.ECSF_1224,iNRG857_1313.NRG857_06385,iUMNK88_1353.UMNK88_1667 SBP_bac_5 k59_292841_2 713586.KB900536_gene2836 3.04e-96 293.0 COG0668@1|root,COG0668@2|Bacteria,1MXD2@1224|Proteobacteria,1RNUB@1236|Gammaproteobacteria,1WYRP@135613|Chromatiales 135613|Chromatiales M Mechanosensitive ion channel - - - ko:K16052 - - - - ko00000,ko02000 1.A.23.4 - - MS_channel k59_969849_1 99158.XP_008885255.1 1.18e-49 175.0 COG0039@1|root,KOG1495@2759|Eukaryota,3Y9XZ@5794|Apicomplexa,3YMKY@5796|Coccidia,3YS4Q@5809|Sarcocystidae 5794|Apicomplexa C Malate dehydrogenase MDH - - - - - - - - - - - Ldh_1_C,Ldh_1_N k59_1309614_1 1123399.AQVE01000004_gene2526 4.08e-65 213.0 COG0075@1|root,COG0075@2|Bacteria,1MWHJ@1224|Proteobacteria,1RMNR@1236|Gammaproteobacteria,4609K@72273|Thiotrichales 72273|Thiotrichales E Aminotransferase class-V - - 2.6.1.44,2.6.1.45,2.6.1.51 ko:K00830 ko00250,ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko04146,map00250,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200,map04146 M00346,M00532 R00369,R00372,R00585,R00588 RC00006,RC00008,RC00018 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_5 k59_1083290_2 436308.Nmar_0773 3.83e-27 100.0 COG1826@1|root,arCOG02694@2157|Archaea,41T8C@651137|Thaumarchaeota 651137|Thaumarchaeota U mttA/Hcf106 family - - - ko:K03116 ko03060,ko03070,map03060,map03070 M00336 - - ko00000,ko00001,ko00002,ko02044 2.A.64 - - MttA_Hcf106 k59_1083290_3 1131266.ARWQ01000002_gene594 7.09e-15 72.4 COG0805@1|root,arCOG01919@2157|Archaea,41S69@651137|Thaumarchaeota 651137|Thaumarchaeota U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes tatC - - ko:K03118 ko03060,ko03070,map03060,map03070 M00336 - - ko00000,ko00001,ko00002,ko02044 2.A.64 - - TatC k59_518102_1 1122137.AQXF01000003_gene2223 1.9e-27 108.0 COG1752@1|root,COG1752@2|Bacteria,1PUT1@1224|Proteobacteria,2U6DW@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Patatin-like phospholipase - - - ko:K07001 - - - - ko00000 - - - Patatin k59_349458_1 1196323.ALKF01000199_gene2643 3.89e-84 261.0 COG0444@1|root,COG0444@2|Bacteria,1TP6E@1239|Firmicutes,4HC95@91061|Bacilli,26UIV@186822|Paenibacillaceae 91061|Bacilli P Belongs to the ABC transporter superfamily - - - ko:K02031 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - ABC_tran,oligo_HPY k59_235665_1 1265503.KB905163_gene2273 1.22e-29 114.0 COG0424@1|root,COG0424@2|Bacteria,1RH6H@1224|Proteobacteria,1S41D@1236|Gammaproteobacteria,2Q728@267889|Colwelliaceae 1236|Gammaproteobacteria D Maf-like protein yhdE GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0030145,GO:0036218,GO:0036221,GO:0042802,GO:0043167,GO:0043169,GO:0046872,GO:0046914,GO:0047429 - ko:K06287 - - - - ko00000 - - - Maf k59_235665_2 1049564.TevJSym_ao00730 7.08e-06 50.4 COG2891@1|root,COG2891@2|Bacteria,1RER7@1224|Proteobacteria,1S8VI@1236|Gammaproteobacteria,1J73I@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins mreD GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0008360,GO:0016020,GO:0016021,GO:0022603,GO:0022604,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0065007,GO:0065008,GO:0071944 - ko:K03571 - - - - ko00000,ko03036 9.B.157.1 - - MreD k59_973893_1 1192868.CAIU01000008_gene938 1.03e-30 120.0 COG0553@1|root,COG0553@2|Bacteria,1R7CK@1224|Proteobacteria,2U228@28211|Alphaproteobacteria,43I7K@69277|Phyllobacteriaceae 28211|Alphaproteobacteria KL DEAD-like helicases superfamily - - - - - - - - - - - - Helicase_C,N6_N4_Mtase k59_973893_2 753085.F4YCV3_9CAUD 1.63e-11 64.7 4QB5I@10239|Viruses,4QUT2@35237|dsDNA viruses no RNA stage,4QPQ9@28883|Caudovirales,4QKRP@10699|Siphoviridae 10699|Siphoviridae S helicase activity - - - - - - - - - - - - - k59_1484126_1 1114964.L485_17360 2.98e-78 246.0 COG2159@1|root,COG2159@2|Bacteria,1R4UN@1224|Proteobacteria,2U2QQ@28211|Alphaproteobacteria,2KDHR@204457|Sphingomonadales 204457|Sphingomonadales S Amidohydrolase - - - - - - - - - - - - Amidohydro_2 k59_1426462_1 391616.OA238_c44620 2.48e-110 323.0 COG3293@1|root,COG3293@2|Bacteria,1PVIT@1224|Proteobacteria,2TURP@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Transposase - - - ko:K07492 - - - - ko00000 - - - DDE_Tnp_1,DDE_Tnp_1_2,DUF4096 k59_1370789_1 402626.Rpic_4820 6.01e-45 160.0 COG1680@1|root,COG1680@2|Bacteria,1MVPR@1224|Proteobacteria,2VKAP@28216|Betaproteobacteria,1K3EK@119060|Burkholderiaceae 28216|Betaproteobacteria V beta-lactamase - - - - - - - - - - - - Beta-lactamase k59_466139_1 298655.KI912266_gene4727 9.55e-76 243.0 COG1541@1|root,COG1541@2|Bacteria,2IANT@201174|Actinobacteria 201174|Actinobacteria H Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA) - - - - - - - - - - - - - k59_1370790_1 1122201.AUAZ01000006_gene3888 1.99e-45 156.0 COG1011@1|root,COG1011@2|Bacteria,1NH15@1224|Proteobacteria,1RP27@1236|Gammaproteobacteria,466G1@72275|Alteromonadaceae 1236|Gammaproteobacteria S Haloacid dehalogenase-like hydrolase yrfG GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008252,GO:0008253,GO:0008477,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0016798,GO:0016799,GO:0030145,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0046872,GO:0046914,GO:0050483,GO:0050484 3.1.3.5 ko:K20881 ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110 - R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346 RC00017 ko00000,ko00001,ko01000 - - - HAD_2,Hydrolase k59_1653077_2 1126627.BAWE01000004_gene1998 7.23e-16 80.5 COG0642@1|root,COG2205@2|Bacteria,1NFY3@1224|Proteobacteria,2TSQR@28211|Alphaproteobacteria,3JTDH@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria T HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain MA20_06300 - - - - - - - - - - - HAMP,HATPase_c,HisKA k59_1144014_1 1049564.TevJSym_ae00640 2.39e-78 239.0 COG0607@1|root,COG0640@1|root,COG0607@2|Bacteria,COG0640@2|Bacteria,1R71B@1224|Proteobacteria,1S2D9@1236|Gammaproteobacteria 1236|Gammaproteobacteria K transcriptional regulator, ArsR family - - - - - - - - - - - - HTH_20,HTH_5,Rhodanese k59_127800_1 1458275.AZ34_04075 5.68e-97 295.0 COG1282@1|root,COG1282@2|Bacteria,1MUP4@1224|Proteobacteria,2VIDR@28216|Betaproteobacteria,4AAKQ@80864|Comamonadaceae 28216|Betaproteobacteria C The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane pntB - 1.6.1.2 ko:K00325 ko00760,ko01100,map00760,map01100 - R00112 RC00001 ko00000,ko00001,ko01000 - - - PNTB k59_1144017_1 1185766.DL1_19040 3.27e-16 79.3 COG1079@1|root,COG1079@2|Bacteria,1MVDQ@1224|Proteobacteria,2TSGJ@28211|Alphaproteobacteria,2XMVM@285107|Thioclava 28211|Alphaproteobacteria U Belongs to the binding-protein-dependent transport system permease family MA20_34825 - - ko:K02057 - M00221 - - ko00000,ko00002,ko02000 3.A.1.2 - - BPD_transp_2 k59_1144017_2 1517681.HW45_12230 2.9e-11 65.1 COG0069@1|root,COG3369@1|root,COG0069@2|Bacteria,COG3369@2|Bacteria,1MU7B@1224|Proteobacteria,1RP1C@1236|Gammaproteobacteria,1XSHA@135623|Vibrionales 135623|Vibrionales E Belongs to the glutamate synthase family - - - - - - - - - - - - Glu_synthase,zf-CDGSH k59_1144018_1 316407.85675308 1.95e-88 262.0 COG4133@1|root,COG4133@2|Bacteria,1MZPC@1224|Proteobacteria,1S3R2@1236|Gammaproteobacteria,3XPCV@561|Escherichia 1236|Gammaproteobacteria O once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system ccmA GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0009898,GO:0015232,GO:0015886,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019897,GO:0019898,GO:0022857,GO:0031224,GO:0031234,GO:0032991,GO:0042623,GO:0043190,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051181,GO:0051184,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0098533,GO:0098552,GO:0098562,GO:0098796,GO:0098797,GO:1901678,GO:1902494,GO:1902495,GO:1904949,GO:1990351 3.6.3.41 ko:K02193 ko02010,map02010 M00259 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.107 - iAPECO1_1312.APECO1_4358,iECED1_1282.ECED1_2666,iECS88_1305.ECS88_2348,iECUMN_1333.ECUMN_2536,iLF82_1304.LF82_0273,iNRG857_1313.NRG857_11170,iUMN146_1321.UM146_05800,iUTI89_1310.UTI89_C2479 ABC_tran k59_1144018_2 316407.85675307 6.87e-16 73.9 COG2386@1|root,COG2386@2|Bacteria,1NJB0@1224|Proteobacteria,1RRFJ@1236|Gammaproteobacteria,3XMNW@561|Escherichia 1236|Gammaproteobacteria O Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes ccmB GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0031224,GO:0031226,GO:0032991,GO:0042623,GO:0043190,GO:0044425,GO:0044459,GO:0044464,GO:0071944,GO:0098533,GO:0098796,GO:0098797,GO:1902494,GO:1902495,GO:1904949,GO:1990351 - ko:K02194 ko02010,map02010 M00259 - - ko00000,ko00001,ko00002,ko02000 3.A.1.107 - iECO111_1330.ECO111_2936 CcmB k59_635731_1 1117647.M5M_19220 1.84e-07 53.1 COG1975@1|root,COG1975@2|Bacteria,1MXKU@1224|Proteobacteria,1RQRT@1236|Gammaproteobacteria,1J9YN@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O COG1975 Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family - - - ko:K07402 - - - - ko00000 - - - XdhC_C,XdhC_CoxI k59_635731_2 1123355.JHYO01000019_gene1697 4.96e-29 113.0 COG2068@1|root,COG2068@2|Bacteria,1MW0X@1224|Proteobacteria,2TR5D@28211|Alphaproteobacteria,36YIM@31993|Methylocystaceae 28211|Alphaproteobacteria S MobA-like NTP transferase domain - - 2.7.7.76 ko:K07141 ko00790,map00790 - R11582 - ko00000,ko00001,ko01000 - - - NTP_transf_3 k59_748507_1 118161.KB235922_gene1370 1.46e-44 158.0 COG2227@1|root,COG2227@2|Bacteria,1G1XD@1117|Cyanobacteria,3VI2X@52604|Pleurocapsales 1117|Cyanobacteria H C-methyltransferase C-terminal domain - - - - - - - - - - - - Methyltransf_14,Methyltransf_23 k59_1144019_1 1123279.ATUS01000001_gene2408 5.76e-46 162.0 COG1301@1|root,COG1301@2|Bacteria,1MU0Q@1224|Proteobacteria,1RMEN@1236|Gammaproteobacteria,1J4SX@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria U Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family gltP - - ko:K03309 - - - - ko00000 2.A.23 - - SDF k59_1370801_1 1245469.S58_48080 2.71e-43 149.0 COG1943@1|root,COG1943@2|Bacteria,1P19I@1224|Proteobacteria,2TR9D@28211|Alphaproteobacteria,3JTU4@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria L Transposase IS200 like - - - ko:K07491 - - - - ko00000 - - - Y1_Tnp k59_71682_1 215803.DB30_6467 1.28e-43 165.0 COG3973@1|root,COG3973@2|Bacteria,1MZQF@1224|Proteobacteria,42UXS@68525|delta/epsilon subdivisions,2WQJ8@28221|Deltaproteobacteria,2YYYK@29|Myxococcales 28221|Deltaproteobacteria L UvrD-like helicase C-terminal domain - - - - - - - - - - - - AAA_19,UvrD-helicase,UvrD_C_2 k59_71682_2 1238450.VIBNISOn1_1530056 1.74e-34 135.0 COG2274@1|root,COG2274@2|Bacteria,1R2T0@1224|Proteobacteria,1SBE1@1236|Gammaproteobacteria,1XTY1@135623|Vibrionales 135623|Vibrionales V COG2274 ABC-type bacteriocin lantibiotic exporters, contain an N-terminal double-glycine peptidase domain lapB - - ko:K12541 ko02010,map02010 M00330 - - ko00000,ko00001,ko00002,ko02000,ko02044 3.A.1.109.3,3.A.1.109.4 - - ABC_membrane,ABC_tran,Peptidase_C39 k59_466157_1 1234364.AMSF01000015_gene3109 1.3e-50 177.0 COG0314@1|root,COG0476@1|root,COG0314@2|Bacteria,COG0476@2|Bacteria,1MW7H@1224|Proteobacteria,1RPJ3@1236|Gammaproteobacteria,1X3YQ@135614|Xanthomonadales 135614|Xanthomonadales H ATP-dependent adenylate transferase, transfers adenyl moiety to the MoeD subunit of molybdopterin synthase moeB - - - - - - - - - - - Rhodanese,ThiF k59_1087681_1 1445613.JALM01000075_gene200 7.21e-30 119.0 296TN@1|root,31VNE@2|Bacteria,2I4U0@201174|Actinobacteria,4E672@85010|Pseudonocardiales 201174|Actinobacteria S Sulfotransferase family - - - - - - - - - - - - Sulfotransfer_3 k59_862878_1 1042375.AFPL01000029_gene3487 6.54e-16 77.0 COG0793@1|root,COG0793@2|Bacteria,1MU39@1224|Proteobacteria,1RMSR@1236|Gammaproteobacteria,4646K@72275|Alteromonadaceae 1236|Gammaproteobacteria M Belongs to the peptidase S41A family prc GO:0003674,GO:0003824,GO:0004175,GO:0005575,GO:0005623,GO:0005886,GO:0006508,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0016020,GO:0016787,GO:0019538,GO:0023052,GO:0030163,GO:0030288,GO:0030313,GO:0031975,GO:0042221,GO:0042597,GO:0043170,GO:0044238,GO:0044464,GO:0046677,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901565,GO:1901575 3.4.21.102 ko:K03797 - - - - ko00000,ko01000,ko01002 - - - BAGE,DUF3340,PDZ,Peptidase_S41 k59_862878_2 1122194.AUHU01000002_gene2468 2.38e-56 196.0 COG0793@1|root,COG0793@2|Bacteria,1MU39@1224|Proteobacteria,1RMSR@1236|Gammaproteobacteria,4646K@72275|Alteromonadaceae 1236|Gammaproteobacteria M Belongs to the peptidase S41A family prc GO:0003674,GO:0003824,GO:0004175,GO:0005575,GO:0005623,GO:0005886,GO:0006508,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0016020,GO:0016787,GO:0019538,GO:0023052,GO:0030163,GO:0030288,GO:0030313,GO:0031975,GO:0042221,GO:0042597,GO:0043170,GO:0044238,GO:0044464,GO:0046677,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901565,GO:1901575 3.4.21.102 ko:K03797 - - - - ko00000,ko01000,ko01002 - - - BAGE,DUF3340,PDZ,Peptidase_S41 k59_579275_1 304371.MCP_1286 7.63e-21 97.8 COG2202@1|root,arCOG02348@1|root,arCOG02348@2157|Archaea,arCOG06918@2157|Archaea,2Y7T3@28890|Euryarchaeota,2NBM9@224756|Methanomicrobia 2157|Archaea T Contains one ATP-binding region, ATPase-like domain (IPR003594) - - 2.7.7.65 ko:K02488 ko02020,ko04112,map02020,map04112 M00511 R08057 - ko00000,ko00001,ko00002,ko01000,ko02022 - - - GAF,GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg k59_1087683_1 1229909.NSED_08945 4.3e-90 290.0 COG4257@1|root,arCOG06267@1|root,arCOG03564@2157|Archaea,arCOG06267@2157|Archaea,41S5S@651137|Thaumarchaeota 651137|Thaumarchaeota V resistance protein - - - ko:K14166 - - - - ko00000,ko02000 - - - CopC,CopD k59_1032094_1 998088.B565_1950 4.17e-35 125.0 COG2993@1|root,COG2993@2|Bacteria,1MXEY@1224|Proteobacteria,1RPU6@1236|Gammaproteobacteria,1Y4ZK@135624|Aeromonadales 135624|Aeromonadales C Cytochrome C oxidase, mono-heme subunit/FixO ccoO - - ko:K00405 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00156 - - ko00000,ko00001,ko00002 3.D.4.3 - - FixO k59_1032094_2 1123367.C666_05995 5.82e-09 53.9 COG4736@1|root,COG4736@2|Bacteria,1PUF6@1224|Proteobacteria,2VXME@28216|Betaproteobacteria,2KXN0@206389|Rhodocyclales 206389|Rhodocyclales O Cbb3-type cytochrome oxidase ccoQ - - ko:K00407 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00156 - - ko00000,ko00001,ko00002 3.D.4.3 - - FixQ k59_354015_1 926556.Echvi_3114 2.12e-08 60.8 COG1629@1|root,COG4771@2|Bacteria,4NG4Z@976|Bacteroidetes 976|Bacteroidetes P Outer membrane receptor for ferrienterochelin and colicins - - - ko:K16089,ko:K16092 - - - - ko00000,ko02000 1.B.14.1,1.B.14.10,1.B.14.3 - - Plug,TonB_dep_Rec k59_748512_1 1489678.RDMS_04595 5.98e-22 103.0 COG3829@1|root,COG4251@1|root,COG3829@2|Bacteria,COG4251@2|Bacteria,1WMF2@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus T Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) - - - - - - - - - - - - HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_8,PAS_9 k59_692257_2 314278.NB231_15003 2.87e-29 115.0 COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,1RNAM@1236|Gammaproteobacteria,1WWRM@135613|Chromatiales 135613|Chromatiales G PFAM TRAP C4-dicarboxylate transport system permease DctM subunit - - - - - - - - - - - - DctM k59_635745_1 765914.ThisiDRAFT_1553 8.29e-25 107.0 COG0834@1|root,COG4623@1|root,COG0834@2|Bacteria,COG4623@2|Bacteria,1MWDS@1224|Proteobacteria,1RM8W@1236|Gammaproteobacteria,1WXYV@135613|Chromatiales 135613|Chromatiales M Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella - - - ko:K18691 - - - - ko00000,ko01000,ko01011 - - - SBP_bac_3,SLT k59_1484159_1 1122137.AQXF01000002_gene400 1.6e-113 332.0 COG1183@1|root,COG1183@2|Bacteria,1MWD9@1224|Proteobacteria,2TUF7@28211|Alphaproteobacteria 28211|Alphaproteobacteria I Belongs to the CDP-alcohol phosphatidyltransferase class-I family pssA GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 2.7.8.8 ko:K17103 ko00260,ko00564,ko01100,ko01110,map00260,map00564,map01100,map01110 M00093 R01800 RC00002,RC00017,RC02795 ko00000,ko00001,ko00002,ko01000 - - - CDP-OH_P_tran_2,CDP-OH_P_transf k59_1484159_2 1122137.AQXF01000002_gene401 4.75e-16 74.7 COG0688@1|root,COG0688@2|Bacteria,1MW45@1224|Proteobacteria,2TRMG@28211|Alphaproteobacteria 28211|Alphaproteobacteria I Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer) psd - 4.1.1.65 ko:K01613 ko00564,ko01100,ko01110,map00564,map01100,map01110 M00093 R02055 RC00299 ko00000,ko00001,ko00002,ko01000 - - - PS_Dcarbxylase k59_466175_1 1408433.JHXV01000008_gene153 5.03e-63 220.0 COG3291@1|root,COG4188@1|root,COG3291@2|Bacteria,COG4188@2|Bacteria,4NKC2@976|Bacteroidetes,1HZ4A@117743|Flavobacteriia 976|Bacteroidetes S Pkd domain containing protein - - - - - - - - - - - - Chlorophyllase2 k59_14834_1 762376.AXYL_00471 9.07e-40 142.0 COG0111@1|root,COG0111@2|Bacteria,1MU5Z@1224|Proteobacteria,2VJ2T@28216|Betaproteobacteria,3T34R@506|Alcaligenaceae 28216|Betaproteobacteria EH Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family serA2 - 1.1.1.310,1.1.1.399,1.1.1.95 ko:K00058,ko:K16843 ko00260,ko00270,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00270,map00680,map01100,map01120,map01130,map01200,map01230 M00020 R01513,R05693 RC00031 ko00000,ko00001,ko00002,ko01000,ko04147 - - - 2-Hacid_dh,2-Hacid_dh_C k59_14834_2 344747.PM8797T_03454 1.36e-91 280.0 COG0498@1|root,COG0498@2|Bacteria,2IXK6@203682|Planctomycetes 203682|Planctomycetes E Pyridoxal-phosphate dependent enzyme - - 4.2.3.1 ko:K01733 ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230 M00018 R01466,R05086 RC00017,RC00526 ko00000,ko00001,ko00002,ko01000 - - - PALP k59_1144079_1 1265503.KB905161_gene3339 3.16e-36 128.0 COG0563@1|root,COG0563@2|Bacteria,1REQW@1224|Proteobacteria,1S67T@1236|Gammaproteobacteria,2Q6YN@267889|Colwelliaceae 1236|Gammaproteobacteria F COG0563 Adenylate kinase and related kinases - - - - - - - - - - - - AAA_18 k59_14838_1 983545.Glaag_1454 3.34e-65 224.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,464D1@72275|Alteromonadaceae 1236|Gammaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family czcA - - ko:K18138 ko01501,ko01503,map01501,map01503 M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000 2.A.6.2 - - ACR_tran k59_1484190_1 436308.Nmar_1751 4.12e-193 540.0 COG0162@1|root,arCOG01886@2157|Archaea,41S8C@651137|Thaumarchaeota 651137|Thaumarchaeota J Tyrosine--tRNA ligase - - 6.1.1.1 ko:K01866 ko00970,map00970 M00359,M00360 R02918 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - tRNA-synt_1b k59_1540174_1 87626.PTD2_09978 1.29e-57 196.0 2C8CD@1|root,2Z9AD@2|Bacteria,1N17D@1224|Proteobacteria,1RRIP@1236|Gammaproteobacteria,2PZK5@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_14841_1 1282876.BAOK01000002_gene212 4.63e-42 152.0 COG0174@1|root,COG0174@2|Bacteria,1MU6V@1224|Proteobacteria,2TRCP@28211|Alphaproteobacteria,4BPJ4@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria E Glutamine synthetase, catalytic domain glnA1 - 6.3.1.2 ko:K01915 ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 - R00253 RC00010,RC02798 ko00000,ko00001,ko01000,ko04147 - - - Gln-synt_C k59_1144085_1 382464.ABSI01000008_gene4017 7.41e-87 276.0 COG1328@1|root,COG1328@2|Bacteria,46TE5@74201|Verrucomicrobia,2IV27@203494|Verrucomicrobiae 203494|Verrucomicrobiae F Anaerobic ribonucleoside-triphosphate reductase - - 1.1.98.6 ko:K21636 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R11633,R11634,R11635,R11636 RC00613 ko00000,ko00001,ko00002,ko01000 - - - NRDD k59_71749_3 999141.GME_18363 1.08e-12 67.4 COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,1RNBG@1236|Gammaproteobacteria,1XI69@135619|Oceanospirillales 135619|Oceanospirillales L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity polA - 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1 k59_1200953_1 391165.GbCGDNIH1_0167 7.38e-41 144.0 COG0596@1|root,COG0596@2|Bacteria,1MWW8@1224|Proteobacteria,2TS53@28211|Alphaproteobacteria,2JYWX@204441|Rhodospirillales 204441|Rhodospirillales E Belongs to the peptidase S33 family - - 3.4.11.5 ko:K01259 ko00330,map00330 - R00135 - ko00000,ko00001,ko01000,ko01002 - - - Abhydrolase_1 k59_1200953_2 1121423.JONT01000010_gene1754 7.52e-13 68.9 COG1131@1|root,COG1131@2|Bacteria,1TQD5@1239|Firmicutes,25B5R@186801|Clostridia,2600I@186807|Peptococcaceae 186801|Clostridia V ABC-type multidrug transport system ATPase - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_1765720_1 1122604.JONR01000019_gene1165 8.69e-37 131.0 COG0811@1|root,COG0811@2|Bacteria,1PKF8@1224|Proteobacteria,1RRWP@1236|Gammaproteobacteria,1X605@135614|Xanthomonadales 135614|Xanthomonadales U MotA/TolQ/ExbB proton channel family - - - - - - - - - - - - MotA_ExbB k59_127879_1 62928.azo3334 5.16e-23 93.2 2BZNP@1|root,30717@2|Bacteria,1REWN@1224|Proteobacteria,2VRZH@28216|Betaproteobacteria,2KWHQ@206389|Rhodocyclales 206389|Rhodocyclales S Protein of unknown function (DUF2889) - - - - - - - - - - - - DUF2889 k59_127879_2 1005048.CFU_3801 2.4e-57 188.0 COG0045@1|root,COG0045@2|Bacteria,1MVCE@1224|Proteobacteria,2VHBG@28216|Betaproteobacteria,472FC@75682|Oxalobacteraceae 28216|Betaproteobacteria F Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit sucC - 6.2.1.5 ko:K01903 ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374,M00620 R00405,R02404 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000 - - - ATP-grasp_2,Ligase_CoA k59_409889_1 1120934.KB894432_gene6144 1.05e-57 191.0 COG2201@1|root,COG2201@2|Bacteria,2GMBC@201174|Actinobacteria,4E602@85010|Pseudonocardiales 201174|Actinobacteria NT CheB methylesterase cheB - 3.1.1.61,3.5.1.44 ko:K03412 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko02022,ko02035 - - - CheB_methylest,Response_reg k59_297597_1 1088721.NSU_2667 1.3e-81 243.0 COG1513@1|root,COG1513@2|Bacteria,1R9X0@1224|Proteobacteria,2TQYR@28211|Alphaproteobacteria 28211|Alphaproteobacteria P Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide cynS - 4.2.1.104 ko:K01725 ko00910,map00910 - R03546,R10079 RC00952 ko00000,ko00001,ko01000 - - - Cyanate_lyase k59_1087746_1 1415778.JQMM01000001_gene454 1.57e-104 316.0 COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,1RQX2@1236|Gammaproteobacteria,1J5ND@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C COG0277 FAD FMN-containing dehydrogenases IV02_25675 - 1.1.3.15 ko:K00104 ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130 - R00475 RC00042 ko00000,ko00001,ko01000 - - - FAD-oxidase_C,FAD_binding_4 k59_1144103_1 1177179.A11A3_07153 2.88e-27 109.0 COG4221@1|root,COG4221@2|Bacteria,1PWXN@1224|Proteobacteria,1S226@1236|Gammaproteobacteria,1XP3M@135619|Oceanospirillales 135619|Oceanospirillales S Domain of unknown function (DUF4336) - - - - - - - - - - - - DUF4336 k59_127897_1 627192.SLG_12400 2.51e-69 237.0 COG1629@1|root,COG4771@2|Bacteria,1R8R0@1224|Proteobacteria,2TTH0@28211|Alphaproteobacteria,2K0E8@204457|Sphingomonadales 204457|Sphingomonadales P TonB dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_127899_2 1229520.ADIAL_2223 9e-17 82.0 COG0124@1|root,COG0124@2|Bacteria,1TP3D@1239|Firmicutes,4HAM2@91061|Bacilli,27FYQ@186828|Carnobacteriaceae 91061|Bacilli J Histidyl-tRNA synthetase hisS - 6.1.1.21 ko:K01892 ko00970,map00970 M00359,M00360 R03655 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,tRNA-synt_His k59_523236_1 1122137.AQXF01000008_gene3446 2.99e-33 130.0 COG1215@1|root,COG1215@2|Bacteria,1QV36@1224|Proteobacteria,2TW9W@28211|Alphaproteobacteria 28211|Alphaproteobacteria M Glycosyltransferase like family 2 - - - - - - - - - - - - Glycos_transf_2 k59_919260_1 999141.GME_13345 3.09e-63 200.0 COG0088@1|root,COG0088@2|Bacteria,1MXPF@1224|Proteobacteria,1RNNK@1236|Gammaproteobacteria,1XH61@135619|Oceanospirillales 135619|Oceanospirillales J Forms part of the polypeptide exit tunnel rplD - - ko:K02926 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L4 k59_1654355_1 1238182.C882_1634 1.07e-40 144.0 COG3741@1|root,COG3741@2|Bacteria,1MY4D@1224|Proteobacteria,2TSC3@28211|Alphaproteobacteria,2JQCJ@204441|Rhodospirillales 204441|Rhodospirillales E N-formylglutamate amidohydrolase - - 3.5.1.68 ko:K01458 ko00340,ko00630,map00340,map00630 - R00525 RC00165,RC00323 ko00000,ko00001,ko01000 - - - FGase k59_1371919_1 1122137.AQXF01000007_gene3548 2.79e-76 242.0 COG0552@1|root,COG0552@2|Bacteria,1MUDU@1224|Proteobacteria,2TS0M@28211|Alphaproteobacteria 28211|Alphaproteobacteria U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components ftsY - - ko:K03110 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2,3.A.5.7 - - SRP54,SRP54_N k59_523247_1 946483.Cenrod_0355 3.89e-102 311.0 COG1215@1|root,COG1215@2|Bacteria,1MXG7@1224|Proteobacteria,2VK83@28216|Betaproteobacteria,4AEXG@80864|Comamonadaceae 28216|Betaproteobacteria M PFAM Glycosyl transferase, family 2 - - - ko:K11936 ko02026,map02026 - - - ko00000,ko00001,ko01000,ko01003,ko02000 4.D.1.1.2,4.D.1.1.3 GT2 - Cellulose_synt,Glyco_tranf_2_3,Glycos_transf_2 k59_355251_1 1229909.NSED_03740 6.39e-118 341.0 arCOG05906@1|root,arCOG05906@2157|Archaea,41T21@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_580344_1 745718.JADT01000009_gene2954 9.07e-175 504.0 COG0022@1|root,COG1071@1|root,COG0022@2|Bacteria,COG1071@2|Bacteria,4NE71@976|Bacteroidetes,1HXMC@117743|Flavobacteriia 976|Bacteroidetes C Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type bfmBA - 1.2.4.4 ko:K11381 ko00280,ko00640,ko01100,ko01110,ko01130,map00280,map00640,map01100,map01110,map01130 M00036 R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997 RC00027,RC00627,RC02743,RC02883,RC02949,RC02953 br01601,ko00000,ko00001,ko00002,ko01000 - - - E1_dh,Transket_pyr,Transketolase_C k59_636814_2 561231.Pecwa_1219 3.59e-63 207.0 COG2103@1|root,COG2103@2|Bacteria,1MVDR@1224|Proteobacteria,1RN3P@1236|Gammaproteobacteria,1MRGA@122277|Pectobacterium 1236|Gammaproteobacteria S Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate. Together with AnmK, is also required for the utilization of anhydro-N-acetylmuramic acid (anhMurNAc) either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling murQ - 4.2.1.126 ko:K07106 ko00520,ko01100,map00520,map01100 - R08555 RC00397,RC00746 ko00000,ko00001,ko01000 - - - SIS,SIS_2 k59_1485113_1 316407.85676676 9.17e-75 234.0 COG0738@1|root,COG0738@2|Bacteria,1NTMP@1224|Proteobacteria,1RSCQ@1236|Gammaproteobacteria,3XMC1@561|Escherichia 1236|Gammaproteobacteria G response to selenite ion tsgA GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0010035,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0042221,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0071944,GO:0072714 - ko:K06141 - - - - ko00000,ko02000 2.A.1 - - MFS_1 k59_636826_2 1121923.GPUN_1694 9.94e-124 359.0 COG1028@1|root,COG1028@2|Bacteria,1MUBQ@1224|Proteobacteria,1RQJT@1236|Gammaproteobacteria,465Z6@72275|Alteromonadaceae 1236|Gammaproteobacteria IQ COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - - - - - - - - - - - adh_short,adh_short_C2 k59_636826_3 314256.OG2516_13561 0.000279 43.5 COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,2TS8E@28211|Alphaproteobacteria,2PDNA@252301|Oceanicola 28211|Alphaproteobacteria I 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain fadJ - 1.1.1.35,4.2.1.17,5.1.2.3 ko:K01782 ko00071,ko00280,ko00281,ko00310,ko00362,ko00380,ko00410,ko00640,ko00650,ko00903,ko00930,ko01040,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00362,map00380,map00410,map00640,map00650,map00903,map00930,map01040,map01100,map01110,map01120,map01130,map01200,map01212 M00032,M00087 R01975,R03026,R03045,R03276,R04137,R04170,R04203,R04204,R04224,R04737,R04738,R04739,R04740,R04741,R04744,R04745,R04746,R04748,R04749,R05066,R05305,R06411,R06412,R06941,R06942,R07935,R07951,R08093,R08094 RC00029,RC00099,RC00117,RC00241,RC00525,RC00831,RC00834,RC00896,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 - - - 3HCDH,3HCDH_N,ECH_1 k59_749747_1 411473.RUMCAL_03312 2.85e-16 75.9 COG4496@1|root,COG4496@2|Bacteria,1VA04@1239|Firmicutes,24MX9@186801|Clostridia,3WKB9@541000|Ruminococcaceae 186801|Clostridia S protein, YerC YecD - - - - - - - - - - - - Trp_repressor k59_128895_1 1484460.JSWG01000004_gene2482 5.01e-09 58.5 COG0457@1|root,COG0457@2|Bacteria,4NH2K@976|Bacteroidetes,1I1JW@117743|Flavobacteriia 976|Bacteroidetes H tetratricopeptide repeat batC - - - - - - - - - - - TPR_1,TPR_11,TPR_16,TPR_17,TPR_2,TPR_8 k59_128895_2 1347342.BN863_33840 4.86e-73 229.0 COG2304@1|root,COG2304@2|Bacteria,4NF7Y@976|Bacteroidetes,1HYES@117743|Flavobacteriia 976|Bacteroidetes S von Willebrand factor, type A batB - - ko:K07114 - - - - ko00000,ko02000 1.A.13.2.2,1.A.13.2.3 - - BatA,VWA,VWA_2 k59_636837_1 436308.Nmar_1733 1.04e-90 277.0 COG0430@1|root,arCOG04125@2157|Archaea,41T1K@651137|Thaumarchaeota 651137|Thaumarchaeota J Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps (A) adenylation of the enzyme by ATP rtcA - 6.5.1.4 ko:K01974 - - - - ko00000,ko01000 - - - RTC k59_636837_2 1229909.NSED_09230 2.52e-47 156.0 COG5615@1|root,arCOG05392@2157|Archaea,41T4B@651137|Thaumarchaeota 651137|Thaumarchaeota S Copper resistance protein D - - - - - - - - - - - - CopD k59_1485138_1 1267535.KB906767_gene2335 1.92e-34 135.0 COG0577@1|root,COG0577@2|Bacteria,3Y41Z@57723|Acidobacteria,2JI5N@204432|Acidobacteriia 204432|Acidobacteriia V MacB-like periplasmic core domain - - - - - - - - - - - - FtsX,MacB_PCD k59_636841_2 1229909.NSED_09470 2.6e-71 219.0 COG1814@1|root,arCOG01096@2157|Archaea,41T0M@651137|Thaumarchaeota 651137|Thaumarchaeota S VIT family - - - - - - - - - - - - VIT1 k59_863874_1 267608.RSp0096 4.9e-52 187.0 COG3209@1|root,COG3209@2|Bacteria,1MVV1@1224|Proteobacteria,2VM13@28216|Betaproteobacteria,1KH58@119060|Burkholderiaceae 28216|Betaproteobacteria M homology - - - - - - - - - - - - RHS_repeat k59_1541228_1 1144305.PMI02_04687 4.05e-75 233.0 COG3637@1|root,COG3637@2|Bacteria,1N7AR@1224|Proteobacteria 1224|Proteobacteria M Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety - - - - - - - - - - - - DUF481,OMP_b-brl k59_636847_1 1122194.AUHU01000025_gene3466 1.19e-19 93.2 COG3866@1|root,COG3867@1|root,COG3866@2|Bacteria,COG3867@2|Bacteria,1R33X@1224|Proteobacteria,1RYK6@1236|Gammaproteobacteria,46AKC@72275|Alteromonadaceae 1236|Gammaproteobacteria G Glycosyl hydrolase family 53 ganB - 3.2.1.89 ko:K01224 - - - - ko00000,ko01000 - - - Glyco_hydro_53 k59_580428_1 316407.1742687 7.41e-122 348.0 COG2878@1|root,COG2878@2|Bacteria,1MUWU@1224|Proteobacteria,1RNSJ@1236|Gammaproteobacteria,3XPHR@561|Escherichia 1236|Gammaproteobacteria C Part of a membrane complex involved in electron transport. Required to maintain the reduced state of SoxR rnfB GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0055114 - ko:K03616 - - - - ko00000 - - - FeS,Fer4_21 k59_580435_1 1088721.NSU_0160 1.76e-18 83.2 COG2272@1|root,COG2272@2|Bacteria,1P0SV@1224|Proteobacteria,2UUWE@28211|Alphaproteobacteria,2K72M@204457|Sphingomonadales 204457|Sphingomonadales I Belongs to the type-B carboxylesterase lipase family - - - - - - - - - - - - - k59_698487_2 944481.JAFP01000001_gene1071 2.14e-35 134.0 COG1884@1|root,COG2185@1|root,COG1884@2|Bacteria,COG2185@2|Bacteria,1MUXX@1224|Proteobacteria,42P03@68525|delta/epsilon subdivisions,2WIPY@28221|Deltaproteobacteria,2M6M5@213113|Desulfurellales 28221|Deltaproteobacteria I Methylmalonyl-CoA mutase mutB - 5.4.99.2 ko:K01847,ko:K01848 ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200 M00373,M00375,M00376,M00741 R00833 RC00395 ko00000,ko00001,ko00002,ko01000 - - - B12-binding,MM_CoA_mutase k59_303752_1 1088721.NSU_pLA2060 4.8e-35 127.0 COG0629@1|root,COG0629@2|Bacteria,1RDCZ@1224|Proteobacteria,2UERA@28211|Alphaproteobacteria,2K53F@204457|Sphingomonadales 204457|Sphingomonadales L Single-strand binding protein family - - - ko:K03111 ko03030,ko03430,ko03440,map03030,map03430,map03440 - - - ko00000,ko00001,ko03029,ko03032,ko03400 - - - SSB k59_868942_2 1121920.AUAU01000008_gene1613 1.28e-38 142.0 COG5557@1|root,COG5557@2|Bacteria,3Y3NS@57723|Acidobacteria 57723|Acidobacteria C PFAM Polysulphide reductase, NrfD - - - - - - - - - - - - NrfD k59_1546369_1 1089551.KE386572_gene2049 8.22e-26 110.0 COG0845@1|root,COG0845@2|Bacteria,1MUI8@1224|Proteobacteria,2TSP0@28211|Alphaproteobacteria,4BQ6Y@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria M HlyD family secretion protein - - - ko:K02022,ko:K12542 - M00330 - - ko00000,ko00002,ko02000,ko02044 3.A.1.109.4,8.A.1 - - Biotin_lipoyl_2,HlyD,HlyD_3 k59_1715312_1 1049564.TevJSym_ae00550 2.25e-110 352.0 COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,1SP6I@1236|Gammaproteobacteria,1J50T@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family czcA - - ko:K15726 - - - - ko00000,ko02000 2.A.6.1.2 - - ACR_tran k59_585345_2 114615.BRADO0007 1.24e-39 138.0 COG3000@1|root,COG3000@2|Bacteria,1MW5G@1224|Proteobacteria,2TU63@28211|Alphaproteobacteria,3JVEM@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria I Fatty acid hydroxylase superfamily - - - - - - - - - - - - FA_hydroxylase k59_78194_1 925775.XVE_3044 8.62e-70 226.0 COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,1RMBQ@1236|Gammaproteobacteria,1X5H3@135614|Xanthomonadales 135614|Xanthomonadales C Belongs to the aldehyde dehydrogenase family xylC - 1.2.1.28,1.2.1.3 ko:K00128,ko:K00141 ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00622,ko00623,ko00625,ko00627,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00622,map00623,map00625,map00627,map00903,map00981,map01100,map01110,map01120,map01130,map01220 M00135,M00537,M00538 R00264,R00631,R00710,R00904,R01293,R01419,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R05289,R05663,R05664,R06366,R07667,R08146 RC00047,RC00071,RC00075,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_246271_1 1121937.AUHJ01000012_gene2720 9.25e-55 184.0 COG1960@1|root,COG1960@2|Bacteria,1MUBH@1224|Proteobacteria,1RPNI@1236|Gammaproteobacteria,46AES@72275|Alteromonadaceae 1236|Gammaproteobacteria I COG1960 Acyl-CoA dehydrogenases - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_1262778_1 13690.CP98_03777 4.97e-19 85.5 COG2030@1|root,COG2030@2|Bacteria,1NTV7@1224|Proteobacteria,2UQFU@28211|Alphaproteobacteria,2K8I3@204457|Sphingomonadales 204457|Sphingomonadales I N-terminal half of MaoC dehydratase - - - - - - - - - - - - MaoC_dehydrat_N k59_1262778_2 13690.CP98_03777 7.58e-40 142.0 COG2030@1|root,COG2030@2|Bacteria,1NTV7@1224|Proteobacteria,2UQFU@28211|Alphaproteobacteria,2K8I3@204457|Sphingomonadales 204457|Sphingomonadales I N-terminal half of MaoC dehydratase - - - - - - - - - - - - MaoC_dehydrat_N k59_1150197_1 702113.PP1Y_AT855 6.2e-93 277.0 COG5375@1|root,COG5375@2|Bacteria,1NMV8@1224|Proteobacteria,2VCS4@28211|Alphaproteobacteria,2K34V@204457|Sphingomonadales 204457|Sphingomonadales S Protein conserved in bacteria - - - ko:K11719 - - - - ko00000,ko02000 1.B.42.1 - - LptC k59_1150197_2 702113.PP1Y_AT851 1.59e-55 178.0 COG1934@1|root,COG1934@2|Bacteria,1MXGA@1224|Proteobacteria,2U6DD@28211|Alphaproteobacteria,2K3YP@204457|Sphingomonadales 204457|Sphingomonadales S protein conserved in bacteria - - - ko:K09774 - - - - ko00000,ko02000 1.B.42.1 - - OstA k59_1150206_1 1049564.TevJSym_ak00080 3.31e-32 126.0 COG3071@1|root,COG3071@2|Bacteria,1MU7A@1224|Proteobacteria,1RMRG@1236|Gammaproteobacteria,1J5RD@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H enzyme of heme biosynthesis hemY GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K02498 - - - - ko00000 - - - HemY_N,TPR_2 k59_1150208_1 1246995.AFR_28480 1.96e-09 64.3 COG0515@1|root,COG2199@1|root,COG3899@1|root,COG0515@2|Bacteria,COG3706@2|Bacteria,COG3899@2|Bacteria,2IBPU@201174|Actinobacteria,4DAU6@85008|Micromonosporales 201174|Actinobacteria T Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - - - - - - - - - - AAA_16,GAF,GAF_3,GGDEF,Guanylate_cyc,Pkinase k59_1602568_1 641526.ADIWIN_2132 4.32e-72 229.0 COG4531@1|root,COG4531@2|Bacteria,4NF0R@976|Bacteroidetes,1HY1X@117743|Flavobacteriia 976|Bacteroidetes P Quinol cytochrome c oxidoreductase actF - - - - - - - - - - - - k59_1602568_2 641526.ADIWIN_2131 9.41e-46 157.0 COG1622@1|root,COG1622@2|Bacteria,4NFNF@976|Bacteroidetes,1HWR6@117743|Flavobacteriia 976|Bacteroidetes C Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) ctaC - 1.9.3.1 ko:K02275 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.4,3.D.4.6 - - COX2,COX2_TM k59_924298_1 224308.BSU36370 2.07e-36 129.0 COG0764@1|root,COG0764@2|Bacteria,1V6EX@1239|Firmicutes,4HGX1@91061|Bacilli,1ZFJ9@1386|Bacillus 91061|Bacilli I Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs fabZ - 4.2.1.59 ko:K02372 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04428,R04535,R04537,R04544,R04568,R04954,R04965,R07764,R10117,R10121 RC00831,RC01095 ko00000,ko00001,ko00002,ko01000,ko01004 - - - FabA k59_1093582_1 1121937.AUHJ01000007_gene1784 1.03e-139 405.0 COG0004@1|root,COG0004@2|Bacteria,1NR9F@1224|Proteobacteria,1RNKF@1236|Gammaproteobacteria,4652P@72275|Alteromonadaceae 1236|Gammaproteobacteria P Ammonium transporter amtB - - ko:K03320 - - - - ko00000,ko02000 1.A.11 - - Ammonium_transp k59_1093582_2 998674.ATTE01000001_gene325 5.57e-31 112.0 COG0347@1|root,COG0347@2|Bacteria,1RGWK@1224|Proteobacteria,1S67I@1236|Gammaproteobacteria,460Q2@72273|Thiotrichales 1236|Gammaproteobacteria K nitrogen regulatory protein P-II glnK - - ko:K04751,ko:K04752 ko02020,map02020 - - - ko00000,ko00001 - - - P-II k59_1715352_1 199310.c1697 1.95e-29 107.0 COG3012@1|root,COG3012@2|Bacteria,1MZZK@1224|Proteobacteria,1S9FV@1236|Gammaproteobacteria,3XPSS@561|Escherichia 1236|Gammaproteobacteria S Belongs to the UPF0225 family ychJ - - ko:K09858 - - - - ko00000 - - - SEC-C k59_1715352_2 316407.4062803 5.81e-59 189.0 COG1752@1|root,COG1752@2|Bacteria,1MUM9@1224|Proteobacteria,1RRA1@1236|Gammaproteobacteria,3XQ8D@561|Escherichia 1236|Gammaproteobacteria S phosphatidylcholine metabolic process rssA GO:0003674,GO:0003824,GO:0016787 - ko:K07001 - - - - ko00000 - - - Patatin k59_641724_1 314278.NB231_11114 1.47e-12 70.1 COG4257@1|root,COG4257@2|Bacteria,1QR8W@1224|Proteobacteria,1RQM4@1236|Gammaproteobacteria,1X0DH@135613|Chromatiales 135613|Chromatiales V Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2-amino-butenoic acid - - - ko:K18235 - - - - ko00000,ko01000,ko01504 - - - - k59_190324_1 1201288.M900_1631 1.52e-09 63.2 COG0181@1|root,COG0181@2|Bacteria,1MU56@1224|Proteobacteria,42M84@68525|delta/epsilon subdivisions,2MSZP@213481|Bdellovibrionales,2WJ5V@28221|Deltaproteobacteria 213481|Bdellovibrionales H Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps hemC GO:0003674,GO:0003824,GO:0004418,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.61 ko:K01749 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R00084 RC02317 ko00000,ko00001,ko00002,ko01000 - - - Porphobil_deam,Porphobil_deamC k59_1150224_1 583345.Mmol_0398 2.04e-32 116.0 COG4654@1|root,COG4654@2|Bacteria,1N6UN@1224|Proteobacteria,2VW1Y@28216|Betaproteobacteria,2KMZ0@206350|Nitrosomonadales 206350|Nitrosomonadales C PFAM cytochrome c, class I - - - ko:K08738 ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416 M00595 R10151 RC03151,RC03152 ko00000,ko00001,ko00002 3.D.4.6 - - Cytochrom_C,Cytochrome_CBB3 k59_1262802_1 357808.RoseRS_0321 4.73e-28 116.0 COG0037@1|root,COG0634@1|root,COG0037@2|Bacteria,COG0634@2|Bacteria,2G6AD@200795|Chloroflexi,374VQ@32061|Chloroflexia 32061|Chloroflexia D Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine tilS - 2.4.2.8,6.3.4.19 ko:K00760,ko:K04075 ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 - R00190,R01132,R01229,R02142,R08237,R08238,R08245,R09597 RC00063,RC00122,RC02633,RC02634 ko00000,ko00001,ko01000,ko03016 - - - ATP_bind_3,Pribosyltran,TilS,TilS_C k59_472922_2 187272.Mlg_2853 1.67e-49 165.0 COG2863@1|root,COG2863@2|Bacteria,1N2NB@1224|Proteobacteria,1RZFP@1236|Gammaproteobacteria,1WYDI@135613|Chromatiales 135613|Chromatiales C PFAM Cytochrome c, class I - - - - - - - - - - - - Cytochrom_C k59_1660256_1 1123269.NX02_19090 2.09e-25 106.0 COG1228@1|root,COG1228@2|Bacteria,1MVAF@1224|Proteobacteria,2TTYC@28211|Alphaproteobacteria,2K0Q2@204457|Sphingomonadales 204457|Sphingomonadales Q COG1228 Imidazolonepropionase and related amidohydrolases - - - - - - - - - - - - Amidohydro_1 k59_528690_1 929712.KI912613_gene4472 1.05e-76 243.0 COG1804@1|root,COG1804@2|Bacteria,2GKNX@201174|Actinobacteria,4CS36@84995|Rubrobacteria 201174|Actinobacteria C CoA-transferase family III - - 5.1.99.4 ko:K01796 ko00120,ko01100,ko04146,map00120,map01100,map04146 M00104 R08734,R08739 RC02345 ko00000,ko00001,ko00002,ko01000 - - - CoA_transf_3 k59_304985_1 1088721.NSU_1245 2.37e-36 134.0 COG4235@1|root,COG4235@2|Bacteria,1MY4J@1224|Proteobacteria,2TSI7@28211|Alphaproteobacteria,2K1X1@204457|Sphingomonadales 204457|Sphingomonadales O cytochrome c biogenesis - - - ko:K02200 - - - - ko00000 - - - TPR_11,TPR_14,TPR_16,TPR_2 k59_304985_2 46429.BV95_04136 2.42e-09 57.4 COG0492@1|root,COG0664@1|root,COG1142@1|root,COG0492@2|Bacteria,COG0664@2|Bacteria,COG1142@2|Bacteria,1QUPD@1224|Proteobacteria,2TW3N@28211|Alphaproteobacteria,2K28S@204457|Sphingomonadales 204457|Sphingomonadales C 4Fe-4S dicluster domain - - - - - - - - - - - - Fer4_7,Pyr_redox_2,Pyr_redox_3,cNMP_binding k59_361593_1 983920.Y88_1713 2.37e-16 74.7 COG1522@1|root,COG1522@2|Bacteria,1MXVU@1224|Proteobacteria,2TTCK@28211|Alphaproteobacteria,2K44J@204457|Sphingomonadales 204457|Sphingomonadales K transcriptional - - - - - - - - - - - - AsnC_trans_reg,HTH_24 k59_586531_1 1415778.JQMM01000001_gene85 1.59e-104 314.0 COG0330@1|root,COG0330@2|Bacteria,1MUM2@1224|Proteobacteria,1RMUG@1236|Gammaproteobacteria,1J4H5@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O HflC and HflK could encode or regulate a protease hflK GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006508,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008233,GO:0009266,GO:0009408,GO:0009628,GO:0009897,GO:0009986,GO:0016020,GO:0016021,GO:0016787,GO:0019538,GO:0031224,GO:0031226,GO:0031233,GO:0032991,GO:0043086,GO:0043170,GO:0044092,GO:0044238,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0050790,GO:0050896,GO:0065007,GO:0065009,GO:0071575,GO:0071704,GO:0071944,GO:0098552,GO:0098796,GO:0140096,GO:1901564 - ko:K04088 - M00742 - - ko00000,ko00002,ko01000 - - - Band_7,HflK_N k59_1491395_1 640081.Dsui_2696 2.85e-53 189.0 COG2844@1|root,COG2844@2|Bacteria,1MV54@1224|Proteobacteria,2VI2G@28216|Betaproteobacteria,2KV4M@206389|Rhodocyclales 206389|Rhodocyclales O Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen glnD - 2.7.7.59 ko:K00990 ko02020,map02020 - - - ko00000,ko00001,ko01000 - - - ACT,GlnD_UR_UTase,HD,NTP_transf_2 k59_1660263_1 1229909.NSED_00120 8.16e-95 286.0 COG0192@1|root,arCOG07444@2157|Archaea,41S5P@651137|Thaumarchaeota 651137|Thaumarchaeota H S-adenosylmethionine synthetase - - 2.5.1.6 ko:K00789 ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230 M00034,M00035,M00368,M00609 R00177,R04771 RC00021,RC01211 ko00000,ko00001,ko00002,ko01000 - - - S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N k59_1660263_3 1229909.NSED_00130 2.39e-93 278.0 COG0468@1|root,arCOG00417@2157|Archaea,41SQC@651137|Thaumarchaeota 651137|Thaumarchaeota T RecA RadA - - - ko:K04482,ko:K04483 ko03440,ko03460,ko05200,ko05212,map03440,map03460,map05200,map05212 - - - ko00000,ko00001,ko03400,ko04121,ko04131 - - - Rad51 k59_812407_1 1502770.JQMG01000001_gene2070 1.05e-50 182.0 COG0492@1|root,COG0664@1|root,COG1142@1|root,COG0492@2|Bacteria,COG0664@2|Bacteria,COG1142@2|Bacteria 2|Bacteria C 4 iron, 4 sulfur cluster binding trxB_2 - 1.18.1.2,1.19.1.1,1.8.1.9,2.7.2.1 ko:K00384,ko:K00925,ko:K21567 ko00430,ko00450,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00450,map00620,map00640,map00680,map00720,map01100,map01120,map01200 M00357,M00579 R00315,R01353,R02016,R03596,R09372 RC00002,RC00013,RC00043,RC02518,RC02873 ko00000,ko00001,ko00002,ko01000 - - - Fer4_7,Pyr_redox_2,Pyr_redox_3,cNMP_binding k59_1263570_1 34506.g2227 2.14e-43 161.0 COG0524@1|root,COG0642@1|root,KOG0519@2759|Eukaryota,KOG2855@2759|Eukaryota 2759|Eukaryota G carbohydrate kinase activity - - - - - - - - - - - - HATPase_c,HisKA,PAS,PfkB,Response_reg k59_699720_1 717606.PaecuDRAFT_0257 7.66e-20 92.0 COG2264@1|root,COG2264@2|Bacteria,1TPKI@1239|Firmicutes,4HAMF@91061|Bacilli,26RIX@186822|Paenibacillaceae 91061|Bacilli J Methylates ribosomal protein L11 prmA - - ko:K02687 - - - - ko00000,ko01000,ko03009 - - - PrmA k59_870158_1 1229780.BN381_80376 1.52e-43 158.0 COG2132@1|root,COG3794@1|root,COG2132@2|Bacteria,COG3794@2|Bacteria,2HZAX@201174|Actinobacteria,3UXS1@52018|unclassified Actinobacteria (class) 201174|Actinobacteria C Copper binding proteins, plastocyanin/azurin family - - - - - - - - - - - - Copper-bind k59_642566_1 314285.KT71_01160 1.87e-61 191.0 COG0049@1|root,COG0049@2|Bacteria,1MXC8@1224|Proteobacteria,1RN77@1236|Gammaproteobacteria,1J9TM@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA rpsG GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006417,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015935,GO:0016043,GO:0017148,GO:0019222,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065003,GO:0065007,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0080090,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904,GO:2000112,GO:2000113 - ko:K02992 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S7 k59_980664_1 247639.MGP2080_05677 6.78e-44 162.0 COG1262@1|root,COG1262@2|Bacteria,1NQ5K@1224|Proteobacteria,1RQVS@1236|Gammaproteobacteria,1J55S@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Sulfatase-modifying factor enzyme 1 - - - - - - - - - - - - FGE-sulfatase,PEGA k59_22057_1 493475.GARC_1745 7.09e-49 174.0 COG4773@1|root,COG4773@2|Bacteria,1QTXJ@1224|Proteobacteria,1T2BS@1236|Gammaproteobacteria,46D8F@72275|Alteromonadaceae 1236|Gammaproteobacteria P TonB dependent receptor - - - - - - - - - - - - Plug,TonB_dep_Rec k59_1378290_1 395494.Galf_0552 1.21e-94 307.0 COG0086@1|root,COG0086@2|Bacteria,1MU3M@1224|Proteobacteria,2VIF3@28216|Betaproteobacteria,44VNH@713636|Nitrosomonadales 28216|Betaproteobacteria K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoC - 2.7.7.6 ko:K03046 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5 k59_1491415_2 436308.Nmar_1712 5.6e-197 560.0 COG1361@1|root,arCOG02080@2157|Archaea,41T6N@651137|Thaumarchaeota 651137|Thaumarchaeota M extracellular matrix structural constituent - - - - - - - - - - - - - k59_472957_1 1163407.UU7_03612 2.97e-41 157.0 2C8CD@1|root,2Z9AD@2|Bacteria,1N17D@1224|Proteobacteria,1RRIP@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_755419_1 1122137.AQXF01000004_gene1724 2.95e-29 111.0 arCOG10116@1|root,315E2@2|Bacteria,1MYJ7@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_586564_1 1306174.JODP01000001_gene5101 5.82e-29 113.0 2DHEM@1|root,32U94@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - Peptidase_M15_4 k59_586565_1 153948.NAL212_1384 2.99e-30 127.0 COG2887@1|root,COG3893@1|root,COG2887@2|Bacteria,COG3893@2|Bacteria,1QU90@1224|Proteobacteria,2VHNR@28216|Betaproteobacteria,37212@32003|Nitrosomonadales 28216|Betaproteobacteria L PD-(D/E)XK nuclease superfamily - - 3.1.11.5 ko:K01144 - - - - ko00000,ko01000 - - - PDDEXK_1 k59_528725_1 768671.ThimaDRAFT_4550 3.3e-37 135.0 2BX2I@1|root,2Z9KR@2|Bacteria,1MXKC@1224|Proteobacteria,1RRV2@1236|Gammaproteobacteria,1WXVA@135613|Chromatiales 135613|Chromatiales - - - - - - - - - - - - - - - k59_870192_1 1122185.N792_00050 4.01e-71 231.0 COG0706@1|root,COG0706@2|Bacteria,1MV5M@1224|Proteobacteria,1RMH1@1236|Gammaproteobacteria,1X497@135614|Xanthomonadales 135614|Xanthomonadales U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins yidC - - ko:K03217 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044,ko03029 2.A.9 - - 60KD_IMP,YidC_periplas k59_417037_1 1167006.UWK_02676 1.35e-24 104.0 COG0405@1|root,COG0405@2|Bacteria,1MUV6@1224|Proteobacteria,42NY8@68525|delta/epsilon subdivisions,2WJNT@28221|Deltaproteobacteria 28221|Deltaproteobacteria E gamma-glutamyltransferase - - 2.3.2.2,3.4.19.13 ko:K00681 ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100 - R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935 RC00064,RC00090,RC00096 ko00000,ko00001,ko01000,ko01002 - - - G_glu_transpept k59_79427_1 187272.Mlg_0289 5.54e-70 224.0 COG1004@1|root,COG1004@2|Bacteria,1MW5U@1224|Proteobacteria,1RMVW@1236|Gammaproteobacteria,1WX6X@135613|Chromatiales 135613|Chromatiales C Belongs to the UDP-glucose GDP-mannose dehydrogenase family - - 1.1.1.22 ko:K00012 ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100 M00014,M00129,M00361,M00362 R00286 RC00291 ko00000,ko00001,ko00002,ko01000 - - - UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N k59_1094541_1 177437.HRM2_47440 1.61e-72 244.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MQ0@68525|delta/epsilon subdivisions,2WISW@28221|Deltaproteobacteria,2MIUG@213118|Desulfobacterales 28221|Deltaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_1320939_1 1229909.NSED_09750 5.8e-95 280.0 COG3945@1|root,arCOG01471@2157|Archaea,41T45@651137|Thaumarchaeota 651137|Thaumarchaeota S Hemerythrin HHE cation binding domain - - - - - - - - - - - - Hemerythrin k59_1320939_2 436308.Nmar_0021 7.9e-21 91.7 COG3263@1|root,arCOG01962@2157|Archaea,41SV3@651137|Thaumarchaeota 651137|Thaumarchaeota P Sodium hydrogen exchanger - - - ko:K11105 - - - - ko00000,ko02000 2.A.36.6 - - Na_H_Exchanger k59_1491453_1 555793.WSK_1870 9.56e-129 377.0 COG0055@1|root,COG0055@2|Bacteria,1MUFU@1224|Proteobacteria,2TRGP@28211|Alphaproteobacteria,2K03H@204457|Sphingomonadales 204457|Sphingomonadales C Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits atpD - 3.6.3.14 ko:K02112 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - - ATP-synt_ab,ATP-synt_ab_N k59_417050_1 243231.GSU2055 3.3e-47 164.0 COG1638@1|root,COG1638@2|Bacteria,1MVHI@1224|Proteobacteria,42M8Y@68525|delta/epsilon subdivisions,2WIZG@28221|Deltaproteobacteria,43T0G@69541|Desulfuromonadales 28221|Deltaproteobacteria G Bacterial extracellular solute-binding protein, family 7 - - - - - - - - - - - - DctP k59_755442_1 5011.R4XEP1 0.00026 48.5 COG0571@1|root,KOG1817@2759|Eukaryota,38CJ5@33154|Opisthokonta,3NYH2@4751|Fungi,3QV6D@4890|Ascomycota,3MCPQ@451866|Taphrinomycotina 4751|Fungi J Double-strand-specific ribonuclease Pac1 - GO:0000294,GO:0000469,GO:0000478,GO:0000956,GO:0003674,GO:0003676,GO:0003723,GO:0003725,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004525,GO:0004540,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005730,GO:0006139,GO:0006325,GO:0006351,GO:0006353,GO:0006364,GO:0006366,GO:0006369,GO:0006396,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009303,GO:0009892,GO:0009987,GO:0010033,GO:0010467,GO:0010468,GO:0010605,GO:0010608,GO:0010629,GO:0014070,GO:0016043,GO:0016070,GO:0016071,GO:0016072,GO:0016073,GO:0016074,GO:0016180,GO:0016246,GO:0016441,GO:0016458,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0018130,GO:0019222,GO:0019438,GO:0019439,GO:0022613,GO:0030422,GO:0030847,GO:0031047,GO:0031050,GO:0031053,GO:0031054,GO:0031123,GO:0031974,GO:0031981,GO:0032296,GO:0032774,GO:0033967,GO:0033979,GO:0034470,GO:0034472,GO:0034473,GO:0034474,GO:0034475,GO:0034476,GO:0034641,GO:0034645,GO:0034654,GO:0034655,GO:0034660,GO:0034963,GO:0034964,GO:0035194,GO:0035195,GO:0035196,GO:0035613,GO:0040029,GO:0042221,GO:0042254,GO:0043144,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043331,GO:0043628,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044271,GO:0044422,GO:0044424,GO:0044428,GO:0044446,GO:0044464,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051276,GO:0051716,GO:0060237,GO:0060255,GO:0065007,GO:0070013,GO:0070887,GO:0070918,GO:0071310,GO:0071359,GO:0071407,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0097659,GO:0098781,GO:0140098,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901575,GO:1901576,GO:1901698,GO:1901699,GO:1903338 3.1.26.3 ko:K03685 ko03008,ko05205,map03008,map05205 - - - ko00000,ko00001,ko01000,ko03009,ko03019,ko03036 - - - Ribonucleas_3_3,Ribonuclease_3,dsrm k59_1491454_2 585543.HMPREF0969_03170 8.55e-49 176.0 COG1501@1|root,COG1501@2|Bacteria,4NE1H@976|Bacteroidetes,2FQU9@200643|Bacteroidia,4AKKF@815|Bacteroidaceae 976|Bacteroidetes G Belongs to the glycosyl hydrolase 31 family - - 3.2.1.20 ko:K01187 ko00052,ko00500,ko01100,map00052,map00500,map01100 - R00028,R00801,R00802,R06087,R06088 RC00028,RC00049,RC00077 ko00000,ko00001,ko01000 - GH31 - DUF4968,DUF5110,Gal_mutarotas_2,Glyco_hydro_31 k59_1208243_1 1088721.NSU_0835 1.37e-176 513.0 COG0643@1|root,COG0643@2|Bacteria,1MUAG@1224|Proteobacteria,2TSN2@28211|Alphaproteobacteria,2K08K@204457|Sphingomonadales 204457|Sphingomonadales NT CheA signal transduction histidine kinase - - 2.7.13.3 ko:K03407 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 - - - CheW,H-kinase_dim,HATPase_c,Hpt k59_1320944_1 1122225.AULQ01000001_gene1726 5.17e-25 101.0 2E4TE@1|root,32ZMS@2|Bacteria,4NX6G@976|Bacteroidetes,1I5N3@117743|Flavobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_22106_1 436308.Nmar_0295 7.52e-111 335.0 COG1245@1|root,arCOG00187@2157|Archaea,41S8K@651137|Thaumarchaeota 651137|Thaumarchaeota E RNase L inhibitor, RLI - - - ko:K06174 - - - - ko00000,ko03009 - - - ABC_tran,Fer4,RLI k59_1320952_1 1042377.AFPJ01000036_gene1207 1.22e-15 77.8 COG1070@1|root,COG1070@2|Bacteria,1MUHF@1224|Proteobacteria,1RRPS@1236|Gammaproteobacteria,464W1@72275|Alteromonadaceae 1236|Gammaproteobacteria G FGGY family of carbohydrate kinases, N-terminal domain - - - - - - - - - - - - FGGY_N k59_1320952_2 1178482.BJB45_20390 3.05e-07 51.6 COG0534@1|root,COG0534@2|Bacteria,1MVRV@1224|Proteobacteria,1RRDQ@1236|Gammaproteobacteria,1XNC1@135619|Oceanospirillales 135619|Oceanospirillales V MatE - - - - - - - - - - - - MatE k59_305080_1 1125863.JAFN01000001_gene769 1.69e-167 495.0 COG0542@1|root,COG0542@2|Bacteria,1MURH@1224|Proteobacteria,42M9S@68525|delta/epsilon subdivisions,2WJSZ@28221|Deltaproteobacteria 28221|Deltaproteobacteria O Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE clpB - - ko:K03695 ko04213,map04213 - - - ko00000,ko00001,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N k59_422612_2 1411685.U062_00856 7.54e-99 293.0 COG0259@1|root,COG0259@2|Bacteria,1NZUU@1224|Proteobacteria,1RMQ2@1236|Gammaproteobacteria,1J5RI@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) pdxH GO:0000166,GO:0003674,GO:0003824,GO:0004733,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008614,GO:0008615,GO:0009058,GO:0009108,GO:0009110,GO:0009443,GO:0009987,GO:0010181,GO:0016491,GO:0016638,GO:0016641,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019842,GO:0032553,GO:0032991,GO:0034641,GO:0036094,GO:0042301,GO:0042364,GO:0042802,GO:0042803,GO:0042816,GO:0042819,GO:0042822,GO:0042823,GO:0043094,GO:0043167,GO:0043168,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046184,GO:0046483,GO:0046983,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617,GO:1902444 1.4.3.5 ko:K00275 ko00750,ko01100,ko01120,map00750,map01100,map01120 M00124 R00277,R00278,R01710,R01711 RC00048,RC00116 ko00000,ko00001,ko00002,ko01000 - - - PNP_phzG_C,Putative_PNPOx k59_422612_3 118797.XP_007471766.1 8.94e-08 52.8 29J1X@1|root,2RS9Y@2759|Eukaryota,3AG7Y@33154|Opisthokonta,3BY7J@33208|Metazoa,3DDMG@33213|Bilateria 33208|Metazoa S Rho termination factor, RNA-binding domain - - - - - - - - - - - - ATP-synt_ab,Rho_N,Rho_RNA_bind k59_707016_1 925409.KI911562_gene276 1.13e-14 75.5 COG5549@1|root,COG5549@2|Bacteria,4NEA0@976|Bacteroidetes 976|Bacteroidetes O Domain of unknown function (DUF5117) - - - - - - - - - - - - DUF4953,DUF5117,DUF5118 k59_141753_1 1122137.AQXF01000002_gene526 4.09e-135 401.0 COG2172@1|root,COG2199@1|root,COG2208@1|root,COG2172@2|Bacteria,COG2208@2|Bacteria,COG3706@2|Bacteria,1N4K5@1224|Proteobacteria,2TS77@28211|Alphaproteobacteria 28211|Alphaproteobacteria T response regulator - - 3.1.3.3 ko:K07315 - - - - ko00000,ko01000,ko03021 - - - Response_reg,SpoIIE k59_1498959_1 314282.PCNPT3_02145 4.62e-87 268.0 COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,1RMWA@1236|Gammaproteobacteria,2QH3F@267894|Psychromonadaceae 1236|Gammaproteobacteria L helicase superfamily c-terminal domain rhlE - 3.6.4.13 ko:K11927 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - DEAD,Helicase_C k59_86805_1 519989.ECTPHS_05145 1.17e-40 153.0 COG5373@1|root,COG5373@2|Bacteria,1N08V@1224|Proteobacteria 1224|Proteobacteria M membrane - - - - - - - - - - - - DUF2339 k59_817147_1 1121939.L861_22710 7.45e-116 347.0 COG0031@1|root,COG0031@2|Bacteria,1MUBE@1224|Proteobacteria,1RN6J@1236|Gammaproteobacteria,1XI2N@135619|Oceanospirillales 135619|Oceanospirillales E Belongs to the cysteine synthase cystathionine beta- synthase family - - 2.5.1.47 ko:K01738 ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230 M00021 R00897,R03601,R04859 RC00020,RC02814,RC02821 ko00000,ko00001,ko00002,ko01000 - - - PALP k59_1385577_1 313628.LNTAR_16753 9.08e-49 168.0 COG2234@1|root,COG2234@2|Bacteria 2|Bacteria DZ aminopeptidase activity yfbL - - - - - - - - - - - Peptidase_M28 k59_1385577_2 768671.ThimaDRAFT_2537 5.08e-128 376.0 COG0372@1|root,COG0372@2|Bacteria,1MUKX@1224|Proteobacteria,1RNDK@1236|Gammaproteobacteria,1WWHU@135613|Chromatiales 135613|Chromatiales C Belongs to the citrate synthase family gltA - 2.3.3.1 ko:K01647 ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00740 R00351 RC00004,RC00067 br01601,ko00000,ko00001,ko00002,ko01000 - - - Citrate_synt k59_1438532_1 316407.85676293 5.15e-137 399.0 COG2425@1|root,COG2425@2|Bacteria,1N1RQ@1224|Proteobacteria,1RPQT@1236|Gammaproteobacteria,3XNVH@561|Escherichia 1236|Gammaproteobacteria S VWA domain protein interacting with AAA ATPase viaA GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0016020,GO:0032781,GO:0043085,GO:0043462,GO:0044093,GO:0044424,GO:0044444,GO:0044464,GO:0050790,GO:0051336,GO:0051345,GO:0065007,GO:0065009 - - - - - - - - - - VWA_CoxE k59_312361_1 926550.CLDAP_05850 3.39e-93 281.0 COG1089@1|root,COG1089@2|Bacteria,2G5P2@200795|Chloroflexi 200795|Chloroflexi M Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose gmd - 4.2.1.47 ko:K01711 ko00051,ko00520,ko01100,map00051,map00520,map01100 - R00888 RC00402 ko00000,ko00001,ko01000 - - - GDP_Man_Dehyd k59_312361_2 1125863.JAFN01000001_gene469 3.32e-09 57.8 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42Y98@68525|delta/epsilon subdivisions,2WTXU@28221|Deltaproteobacteria 1224|Proteobacteria T Bacterial regulatory protein, Fis family actB - - - - - - - - - - - HTH_8,Response_reg,Sigma54_activat k59_86815_1 1415778.JQMM01000001_gene848 1.09e-78 254.0 COG1290@1|root,COG2857@1|root,COG1290@2|Bacteria,COG2857@2|Bacteria,1MV97@1224|Proteobacteria,1RNCP@1236|Gammaproteobacteria,1J5A4@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis petB - - ko:K00412 ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016 M00151,M00152 - - ko00000,ko00001,ko00002,ko03029 - - - Cytochrom_B_C,Cytochrom_C1,Cytochrome_B k59_1216493_1 350058.Mvan_0950 6.18e-18 84.0 2EZUT@1|root,33SZA@2|Bacteria,2GNU4@201174|Actinobacteria,23665@1762|Mycobacteriaceae 201174|Actinobacteria - - - - - - - - - - - - - - - k59_197894_2 13690.CP98_02712 2.07e-65 224.0 COG3250@1|root,COG3250@2|Bacteria,1P9KJ@1224|Proteobacteria,2TV5M@28211|Alphaproteobacteria,2K34U@204457|Sphingomonadales 204457|Sphingomonadales G alpha-L-rhamnosidase - - - - - - - - - - - - Glyco_hydro_106 k59_1499988_1 886377.Murru_1359 3.89e-70 214.0 COG3205@1|root,COG3205@2|Bacteria,4NV6E@976|Bacteroidetes,1I208@117743|Flavobacteriia 976|Bacteroidetes S membrane - - - - - - - - - - - - DUF2061 k59_534325_1 316407.85675700 8.35e-117 346.0 COG2233@1|root,COG2233@2|Bacteria,1MUN9@1224|Proteobacteria,1RMGW@1236|Gammaproteobacteria,3XM66@561|Escherichia 1236|Gammaproteobacteria F Proton-dependent high-capacity transporter for uric acid. Shows also a low capacity for transport of xanthine at 37 degrees Celsius but not at 25 degrees Celsius ygfU GO:0003674,GO:0005215,GO:0005345,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006863,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0015075,GO:0015143,GO:0015205,GO:0015711,GO:0015747,GO:0015851,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0042906,GO:0042907,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0072530,GO:0098655,GO:0098656,GO:1901702,GO:1904823 - ko:K03458 - - - - ko00000 2.A.40 - - Xan_ur_permease k59_878576_1 702113.PP1Y_AT26069 2.34e-102 300.0 COG1923@1|root,COG1923@2|Bacteria,1MZM1@1224|Proteobacteria,2UBTW@28211|Alphaproteobacteria,2K2YT@204457|Sphingomonadales 204457|Sphingomonadales J RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs hfq - - ko:K03666 ko02024,ko03018,ko05111,map02024,map03018,map05111 - - - ko00000,ko00001,ko03019,ko03036 - - - Hfq k59_878576_2 1144305.PMI02_02920 7.07e-30 116.0 COG2262@1|root,COG2262@2|Bacteria,1MUA0@1224|Proteobacteria,2TUXJ@28211|Alphaproteobacteria,2K0SI@204457|Sphingomonadales 204457|Sphingomonadales S GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis hflX - - ko:K03665 - - - - ko00000,ko03009 - - - GTP-bdg_M,GTP-bdg_N,MMR_HSR1 k59_423426_1 1117647.M5M_13155 3.52e-54 179.0 2BKN5@1|root,32F3J@2|Bacteria,1RIMC@1224|Proteobacteria,1S6Q3@1236|Gammaproteobacteria,1J7D1@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Bacterial protein of unknown function (Gcw_chp) - - - - - - - - - - - - Gcw_chp k59_761280_1 172088.AUGA01000267_gene1399 3.05e-99 298.0 COG4372@1|root,COG4372@2|Bacteria,1MUCX@1224|Proteobacteria,2TR59@28211|Alphaproteobacteria,3JT7K@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria L Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - - - - - - - - - - DDE_Tnp_IS66,DDE_Tnp_IS66_C,LZ_Tnp_IS66,zf-IS66 k59_1777339_1 1122137.AQXF01000005_gene1046 2.84e-149 441.0 COG0366@1|root,COG0366@2|Bacteria,1MU90@1224|Proteobacteria,2U0DP@28211|Alphaproteobacteria 28211|Alphaproteobacteria G Alpha amylase catalytic - - - - - - - - - - - - Alpha-amylase k59_708148_1 391603.FBALC1_03307 1.63e-72 237.0 29X8I@1|root,30IXV@2|Bacteria,4P0MB@976|Bacteroidetes 976|Bacteroidetes - - - - - - - - - - - - - - - k59_313499_1 1484460.JSWG01000007_gene3105 3.36e-104 324.0 COG3291@1|root,COG3291@2|Bacteria,4NDZQ@976|Bacteroidetes,1HX5A@117743|Flavobacteriia 976|Bacteroidetes M C-terminal domain of CHU protein family - - - - - - - - - - - - CHU_C,HYR,SprB k59_986864_1 335283.Neut_2466 1.89e-35 137.0 COG0204@1|root,COG0318@1|root,COG0204@2|Bacteria,COG0318@2|Bacteria,1MWDY@1224|Proteobacteria,2VJ4I@28216|Betaproteobacteria,373W6@32003|Nitrosomonadales 28216|Betaproteobacteria I Transmembrane secretion effector aas - 2.3.1.40,6.2.1.20 ko:K05939 ko00071,ko00564,map00071,map00564 - R01406,R04864 RC00014,RC00039,RC00041 ko00000,ko00001,ko01000 - - - Acyltransferase,MFS_1 k59_986864_2 1385515.N791_06100 1.84e-70 225.0 COG1972@1|root,COG1972@2|Bacteria,1MXXX@1224|Proteobacteria,1RMBX@1236|Gammaproteobacteria,1X3AE@135614|Xanthomonadales 135614|Xanthomonadales F Na dependent nucleoside transporter yeiM - - ko:K03317 - - - - ko00000 2.A.41 - - Gate,Nucleos_tra2_C,Nucleos_tra2_N k59_761293_2 1392498.JQLH01000001_gene171 9.4e-12 67.8 COG2866@1|root,COG2866@2|Bacteria,4PE64@976|Bacteroidetes,1IEQP@117743|Flavobacteriia,2PIM0@252356|Maribacter 976|Bacteroidetes E Zinc carboxypeptidase - - - - - - - - - - - - Peptidase_M14 k59_534342_2 1163408.UU9_02963 4.73e-14 68.6 COG3116@1|root,COG3116@2|Bacteria,1NI3C@1224|Proteobacteria,1SGSB@1236|Gammaproteobacteria,1XD1E@135614|Xanthomonadales 135614|Xanthomonadales D Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic ftsL - - ko:K03586 - - - - ko00000,ko03036 - - - FtsL k59_370307_1 1046714.AMRX01000006_gene2655 6.05e-14 81.6 COG3267@1|root,COG3409@1|root,COG3267@2|Bacteria,COG3409@2|Bacteria,1MU3G@1224|Proteobacteria,1RMI0@1236|Gammaproteobacteria,4658U@72275|Alteromonadaceae 1236|Gammaproteobacteria U COG3267 Type II secretory pathway, component ExeA gspA GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944 - ko:K02450 - M00331 - - ko00000,ko00002,ko02044 9.B.42 - - AAA_22,PG_binding_1 k59_1386762_1 13690.CP98_04504 1.55e-74 247.0 COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,2TRFN@28211|Alphaproteobacteria,2K06M@204457|Sphingomonadales 204457|Sphingomonadales C Xanthine dehydrogenase - - 1.2.5.3 ko:K03520 - - R11168 RC02800 ko00000,ko01000 - - - Ald_Xan_dh_C,Ald_Xan_dh_C2 k59_818278_1 95619.PM1_0221115 2.56e-30 119.0 COG4638@1|root,COG4638@2|Bacteria,1MWXW@1224|Proteobacteria,1RYN7@1236|Gammaproteobacteria 1236|Gammaproteobacteria P COG4638 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit yeaW GO:0003674,GO:0005488,GO:0005515,GO:0008150,GO:0009987,GO:0016043,GO:0022607,GO:0042802,GO:0043933,GO:0044085,GO:0048037,GO:0051259,GO:0051260,GO:0051536,GO:0051537,GO:0051540,GO:0065003,GO:0070206,GO:0070207,GO:0071840 1.14.13.239,1.14.15.7 ko:K00499,ko:K22443 ko00260,map00260 - R07409 RC00087 ko00000,ko00001,ko01000 - - - Rieske,Ring_hydroxyl_A k59_1386764_1 928724.SacglDRAFT_02531 4.16e-26 103.0 COG0789@1|root,COG0789@2|Bacteria,2HBV6@201174|Actinobacteria,4DY01@85010|Pseudonocardiales 201174|Actinobacteria K PFAM MerR family regulatory protein merR1 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0040007,GO:0044424,GO:0044444,GO:0044464 - - - - - - - - - - MerR,MerR_1 k59_1386764_2 1003195.SCAT_1997 7.35e-08 55.8 COG1674@1|root,COG1716@1|root,COG1674@2|Bacteria,COG1716@2|Bacteria,2GKQG@201174|Actinobacteria 201174|Actinobacteria DT Forkhead associated domain - - - ko:K03466 - - - - ko00000,ko03036 3.A.12 - - FHA,FtsK_SpoIIIE,Yop-YscD_cpl k59_1270003_1 1123393.KB891316_gene1129 3.27e-44 149.0 COG0693@1|root,COG0693@2|Bacteria,1N7T2@1224|Proteobacteria,2VS5Q@28216|Betaproteobacteria,1KSPI@119069|Hydrogenophilales 119069|Hydrogenophilales S DJ-1/PfpI family - - - - - - - - - - - - DJ-1_PfpI k59_1270003_2 1323663.AROI01000051_gene4005 3.21e-07 53.9 COG2861@1|root,COG2861@2|Bacteria,1N3JP@1224|Proteobacteria,1RNKH@1236|Gammaproteobacteria 1236|Gammaproteobacteria S protein conserved in bacteria yibQ - - ko:K09798 - - - - ko00000 - - - Polysacc_deac_2 k59_30776_1 1440774.Y900_014705 3.54e-18 88.6 COG1020@1|root,COG1020@2|Bacteria,2I5H8@201174|Actinobacteria,232A1@1762|Mycobacteriaceae 201174|Actinobacteria I Belongs to the long-chain O-acyltransferase family - GO:0000302,GO:0001666,GO:0003674,GO:0003824,GO:0004144,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006629,GO:0006638,GO:0006639,GO:0006641,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008374,GO:0008610,GO:0009058,GO:0009628,GO:0009987,GO:0010035,GO:0016020,GO:0016411,GO:0016740,GO:0016746,GO:0016747,GO:0019432,GO:0030312,GO:0036293,GO:0040007,GO:0042221,GO:0042493,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044403,GO:0044419,GO:0044464,GO:0045017,GO:0046460,GO:0046463,GO:0046486,GO:0047196,GO:0050896,GO:0051704,GO:0070482,GO:0071704,GO:0071731,GO:0071944,GO:0097366,GO:1901576,GO:1901698,GO:1901700 2.3.1.20 ko:K00635 ko00561,ko01100,map00561,map01100 M00089 R02251 RC00004,RC00041 ko00000,ko00001,ko00002,ko01000 - - - DUF1298,WES_acyltransf k59_370318_1 1229909.NSED_03740 1.29e-93 277.0 arCOG05906@1|root,arCOG05906@2157|Archaea,41T21@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1386780_1 926569.ANT_13760 2.07e-14 71.2 COG0632@1|root,COG0632@2|Bacteria,2G6V7@200795|Chloroflexi 200795|Chloroflexi L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB ruvA - 3.6.4.12 ko:K03550 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - HHH_5,RuvA_C,RuvA_N k59_1386780_2 515635.Dtur_1304 9.87e-07 52.4 COG0345@1|root,COG0345@2|Bacteria 2|Bacteria E pyrroline-5-carboxylate reductase activity proC GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 1.5.1.2 ko:K00286 ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230 M00015 R01248,R01251,R03291,R03293 RC00054,RC00083 ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_0899,iIT341.HP1158 F420_oxidored,P5CR_dimer k59_878625_1 580332.Slit_1033 7.12e-95 282.0 COG0175@1|root,COG0175@2|Bacteria,1MXUR@1224|Proteobacteria,2VIR0@28216|Betaproteobacteria,44V6T@713636|Nitrosomonadales 28216|Betaproteobacteria C Reduction of activated sulfate into sulfite cysH - 1.8.4.10,1.8.4.8 ko:K00390 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00176 R02021 RC00007,RC02862 ko00000,ko00001,ko00002,ko01000 - - - PAPS_reduct k59_423461_1 1144305.PMI02_00448 5.67e-51 184.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2TQS3@28211|Alphaproteobacteria,2K0SK@204457|Sphingomonadales 204457|Sphingomonadales T Putative diguanylate phosphodiesterase - - - - - - - - - - - - EAL,GGDEF,MHYT,PAS,PAS_4,PAS_7,PAS_9 k59_1666705_1 1267535.KB906767_gene3709 9.26e-10 63.5 COG1538@1|root,COG1538@2|Bacteria,3Y73J@57723|Acidobacteria,2JM9N@204432|Acidobacteriia 204432|Acidobacteriia MU Outer membrane efflux protein - - - - - - - - - - - - OEP k59_479022_1 279238.Saro_3143 1.28e-35 125.0 COG3453@1|root,COG3453@2|Bacteria,1N9AF@1224|Proteobacteria,2UD2M@28211|Alphaproteobacteria,2K56H@204457|Sphingomonadales 204457|Sphingomonadales S protein conserved in bacteria - - - - - - - - - - - - DUF442 k59_479022_2 1088721.NSU_1938 1.86e-13 69.3 2BFZT@1|root,329VR@2|Bacteria,1QEZ5@1224|Proteobacteria,2V5V1@28211|Alphaproteobacteria,2KA3Z@204457|Sphingomonadales 204457|Sphingomonadales - - - - - - - - - - - - - - - k59_370326_1 436308.Nmar_1391 3.28e-148 429.0 COG1498@1|root,arCOG01923@2157|Archaea,41SY9@651137|Thaumarchaeota 651137|Thaumarchaeota J NOSIC (NUC001) domain - - - ko:K14564 ko03008,map03008 - - - ko00000,ko00001,ko03009 - - - Nop k59_986891_1 575788.VS_0002 5.49e-54 184.0 COG0486@1|root,COG0486@2|Bacteria,1MUCQ@1224|Proteobacteria,1RN5S@1236|Gammaproteobacteria,1XTKD@135623|Vibrionales 135623|Vibrionales J Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 mnmE GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009636,GO:0009987,GO:0010467,GO:0016070,GO:0034470,GO:0034641,GO:0034660,GO:0042221,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0050896,GO:0071704,GO:0090304,GO:1901360 - ko:K03650 - - R08701 RC00053,RC00209,RC00870 ko00000,ko01000,ko03016 - - - MMR_HSR1,MnmE_helical,TrmE_N k59_761317_1 382464.ABSI01000011_gene2477 4.85e-60 199.0 COG0707@1|root,COG0707@2|Bacteria,46Z1V@74201|Verrucomicrobia,2IVJ9@203494|Verrucomicrobiae 203494|Verrucomicrobiae M Glycosyltransferase Family 4 - - - - - - - - - - - - - k59_1158740_1 702113.PP1Y_AT35098 1.17e-92 282.0 COG2989@1|root,COG2989@2|Bacteria,1MV14@1224|Proteobacteria,2TRJ9@28211|Alphaproteobacteria,2K0KA@204457|Sphingomonadales 204457|Sphingomonadales S protein conserved in bacteria - - - ko:K21470 - - - - ko00000,ko01002,ko01011 - - - YkuD k59_986895_1 1150399.AQYK01000001_gene443 5.03e-43 162.0 COG1770@1|root,COG1770@2|Bacteria,2GNA9@201174|Actinobacteria,4FMUI@85023|Microbacteriaceae 201174|Actinobacteria E Prolyl oligopeptidase, N-terminal beta-propeller domain ptrB - 3.4.21.83 ko:K01354 ko05142,ko05143,map05142,map05143 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_S9,Peptidase_S9_N k59_1216559_1 1123367.C666_13945 2.08e-65 218.0 COG4232@1|root,COG4232@2|Bacteria,1MU8W@1224|Proteobacteria,2VI8I@28216|Betaproteobacteria,2KV4F@206389|Rhodocyclales 206389|Rhodocyclales CO Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps dsbD - 1.8.1.8 ko:K04084 - - - - ko00000,ko01000,ko03110 5.A.1.1 - - DsbC,DsbD,Thioredoxin_7 k59_931109_1 1088721.NSU_2854 7.29e-79 253.0 COG0471@1|root,COG0490@1|root,COG0471@2|Bacteria,COG0490@2|Bacteria,1MU0K@1224|Proteobacteria,2TSFS@28211|Alphaproteobacteria,2K1E7@204457|Sphingomonadales 204457|Sphingomonadales P Citrate transporter - - - - - - - - - - - - CitMHS,Na_sulph_symp,TrkA_C k59_1101044_1 722419.PH505_ad00140 2.52e-37 146.0 COG1629@1|root,COG4771@2|Bacteria,1MU9K@1224|Proteobacteria,1RMTG@1236|Gammaproteobacteria,2PZDP@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria P COG1629 Outer membrane receptor proteins, mostly Fe transport - - - - - - - - - - - - Plug,TonB_dep_Rec k59_1556922_2 748247.AZKH_0998 1.57e-38 134.0 COG3807@1|root,COG3807@2|Bacteria,1MZIA@1224|Proteobacteria,2VUTD@28216|Betaproteobacteria,2KWXG@206389|Rhodocyclales 206389|Rhodocyclales S Bacterial SH3 domain - - - - - - - - - - - - SH3_4 k59_1326842_1 396588.Tgr7_1602 9.88e-50 169.0 COG2358@1|root,COG2358@2|Bacteria,1NRSC@1224|Proteobacteria 1224|Proteobacteria S TRAP transporter, solute receptor (TAXI family - - - - - - - - - - - - NMT1_3 k59_479036_1 1229909.NSED_01600 3.58e-74 249.0 arCOG08778@1|root,arCOG08778@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_1500059_1 1122137.AQXF01000005_gene1226 8.88e-179 514.0 COG4147@1|root,COG4147@2|Bacteria,1MVJ8@1224|Proteobacteria,2TTA4@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family - - - ko:K14393 - - - - ko00000,ko02000 2.A.21.7 - - SSF k59_761336_1 1120919.AUBI01000003_gene1652 1.78e-30 120.0 COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,2TRYI@28211|Alphaproteobacteria,2JPKJ@204441|Rhodospirillales 204441|Rhodospirillales C COG0277 FAD FMN-containing dehydrogenases - - - - - - - - - - - - FAD-oxidase_C,FAD_binding_4 k59_761336_2 1122137.AQXF01000002_gene509 2.18e-25 98.6 COG0204@1|root,COG0204@2|Bacteria,1RJMS@1224|Proteobacteria,2U5TA@28211|Alphaproteobacteria 28211|Alphaproteobacteria I COG0204 1-acyl-sn-glycerol-3-phosphate acyltransferase - - - - - - - - - - - - Acyltransferase k59_595014_1 1537715.JQFJ01000002_gene1230 7.58e-82 263.0 COG2124@1|root,COG2124@2|Bacteria,1MV75@1224|Proteobacteria,2TSV7@28211|Alphaproteobacteria,2K088@204457|Sphingomonadales 204457|Sphingomonadales Q Cytochrome p450 - - - - - - - - - - - - p450 k59_595016_1 1279009.ADICEAN_04188 4.24e-32 120.0 COG0463@1|root,COG0463@2|Bacteria,4PKIQ@976|Bacteroidetes,47YFC@768503|Cytophagia 976|Bacteroidetes M Glycosyl transferase family 2 - - - - - - - - - - - - Glycos_transf_2 k59_534381_1 760568.Desku_1520 7.18e-84 269.0 COG0007@1|root,COG1587@1|root,COG0007@2|Bacteria,COG1587@2|Bacteria,1TQNH@1239|Firmicutes,2487I@186801|Clostridia,2602S@186807|Peptococcaceae 186801|Clostridia H Belongs to the precorrin methyltransferase family cobA - 1.3.1.76,2.1.1.107,4.2.1.75,4.99.1.4 ko:K02302,ko:K02303,ko:K13542 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R02864,R03165,R03194,R03947 RC00003,RC00871,RC01012,RC01034,RC01861 ko00000,ko00001,ko00002,ko01000 - - iHN637.CLJU_RS15755 HEM4,Porphobil_deam,Porphobil_deamC,TP_methylase k59_534381_2 314225.ELI_09155 2.58e-06 50.8 COG0181@1|root,COG0181@2|Bacteria,1MU56@1224|Proteobacteria,2TS3D@28211|Alphaproteobacteria,2K19Y@204457|Sphingomonadales 204457|Sphingomonadales H Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps hemC - 2.5.1.61 ko:K01749 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R00084 RC02317 ko00000,ko00001,ko00002,ko01000 - - - Porphobil_deam,Porphobil_deamC k59_1556933_1 1415778.JQMM01000001_gene1133 3.26e-33 122.0 29B18@1|root,2ZY02@2|Bacteria,1REMG@1224|Proteobacteria,1S4B1@1236|Gammaproteobacteria,1JA2W@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_818336_1 85643.Tmz1t_0010 1.94e-74 240.0 COG4584@1|root,COG4584@2|Bacteria,1MWIV@1224|Proteobacteria,2VHIG@28216|Betaproteobacteria 28216|Betaproteobacteria L PFAM Integrase catalytic - - - - - - - - - - - - rve k59_818336_2 107636.JQNK01000001_gene48 1.02e-48 163.0 COG1484@1|root,COG1484@2|Bacteria,1MWQX@1224|Proteobacteria,2TRGY@28211|Alphaproteobacteria,36ZYD@31993|Methylocystaceae 28211|Alphaproteobacteria L IstB-like ATP binding protein - - - - - - - - - - - - IstB_IS21 k59_30836_1 1122134.KB893651_gene2359 4.69e-83 253.0 COG0189@1|root,COG0189@2|Bacteria,1MX62@1224|Proteobacteria,1RM8B@1236|Gammaproteobacteria,1XHPG@135619|Oceanospirillales 135619|Oceanospirillales F Belongs to the RimK family - - - ko:K05844 - - - - ko00000,ko01000,ko03009 - - - RimK k59_878669_1 234267.Acid_1765 2.03e-26 116.0 COG0577@1|root,COG0577@2|Bacteria 234267.Acid_1765|- V efflux transmembrane transporter activity - - - - - - - - - - - - - k59_708239_1 998088.B565_3978 1.83e-10 61.2 COG0113@1|root,COG0113@2|Bacteria,1MWMW@1224|Proteobacteria,1RP6Q@1236|Gammaproteobacteria,1Y464@135624|Aeromonadales 135624|Aeromonadales H Belongs to the ALAD family hemB - 4.2.1.24 ko:K01698 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R00036 RC00918,RC01781 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ALAD k59_708239_2 314287.GB2207_07846 7.56e-51 173.0 COG0001@1|root,COG0001@2|Bacteria,1MUY5@1224|Proteobacteria,1RM7N@1236|Gammaproteobacteria,1J53B@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Aminotransferase hemL GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006725,GO:0006778,GO:0006779,GO:0006782,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016853,GO:0016866,GO:0016869,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042286,GO:0042440,GO:0042802,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046483,GO:0046501,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 5.4.3.8 ko:K01845 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R02272 RC00677 ko00000,ko00001,ko00002,ko01000,ko01007 - - iUMNK88_1353.UMNK88_158 Aminotran_3 k59_1556939_1 1123487.KB892865_gene1372 2.34e-51 173.0 2ECIJ@1|root,336GQ@2|Bacteria,1NFBI@1224|Proteobacteria,2VYFZ@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_1216601_1 1122137.AQXF01000002_gene337 7.92e-164 468.0 COG2377@1|root,COG2377@2|Bacteria,1MV4E@1224|Proteobacteria,2TS4G@28211|Alphaproteobacteria 28211|Alphaproteobacteria O Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling anmK - 2.7.1.170 ko:K09001 - - - - ko00000,ko01000 - - - AnmK k59_534395_1 1255043.TVNIR_3064 2.95e-54 181.0 COG2234@1|root,COG2234@2|Bacteria,1MXZS@1224|Proteobacteria,1S0QR@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Peptidase family M28 yfbL - - - - - - - - - - - Peptidase_M28 k59_708247_1 1088721.NSU_0266 7.19e-119 348.0 COG0341@1|root,COG0341@2|Bacteria,1MU74@1224|Proteobacteria,2TSFW@28211|Alphaproteobacteria,2K18K@204457|Sphingomonadales 204457|Sphingomonadales U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA secF - - ko:K03074 ko03060,ko03070,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 2.A.6.4,3.A.5.2,3.A.5.7 - - SecD_SecF,Sec_GG k59_198005_1 443255.SCLAV_4635 8.07e-44 160.0 COG0595@1|root,COG0595@2|Bacteria,2GIW7@201174|Actinobacteria 201174|Actinobacteria S An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay rnj - - ko:K12574 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - Lactamase_B,Lactamase_B_2,RMMBL k59_878687_1 1121035.AUCH01000006_gene680 3.31e-13 67.8 COG1057@1|root,COG1057@2|Bacteria,1RD0J@1224|Proteobacteria,2VSQ7@28216|Betaproteobacteria,2KW3W@206389|Rhodocyclales 206389|Rhodocyclales H Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) nadD - 2.7.7.18 ko:K00969 ko00760,ko01100,map00760,map01100 M00115 R00137,R03005 RC00002 ko00000,ko00001,ko00002,ko01000 - - - CTP_transf_like k59_878687_2 323848.Nmul_A0361 4.82e-43 145.0 COG0799@1|root,COG0799@2|Bacteria,1MZEF@1224|Proteobacteria,2VRRV@28216|Betaproteobacteria,373F4@32003|Nitrosomonadales 28216|Betaproteobacteria J Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation rsfS - - ko:K09710 - - - - ko00000,ko03009 - - - RsfS k59_142649_1 247634.GPB2148_1185 1.34e-85 258.0 COG1028@1|root,COG1028@2|Bacteria,1R413@1224|Proteobacteria,1S3TR@1236|Gammaproteobacteria,1J5M3@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria IQ KR domain - - - - - - - - - - - - adh_short_C2 k59_198012_1 768704.Desmer_3618 4.54e-73 231.0 COG1079@1|root,COG1079@2|Bacteria,1TP8Y@1239|Firmicutes,2486N@186801|Clostridia,26193@186807|Peptococcaceae 186801|Clostridia U Belongs to the binding-protein-dependent transport system permease family - - - ko:K02057 - M00221 - - ko00000,ko00002,ko02000 3.A.1.2 - - BPD_transp_2 k59_1507792_1 1415778.JQMM01000001_gene818 2.72e-244 677.0 COG0174@1|root,COG0174@2|Bacteria,1MUGQ@1224|Proteobacteria,1RMD1@1236|Gammaproteobacteria,1J4KI@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E glutamine synthetase glnA - 6.3.1.2 ko:K01915 ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 - R00253 RC00010,RC02798 ko00000,ko00001,ko01000,ko04147 - - iJN746.PP_5046 Gln-synt_C,Gln-synt_N k59_378075_1 1122137.AQXF01000006_gene915 1.39e-12 65.9 COG2199@1|root,COG3706@2|Bacteria,1QZ3H@1224|Proteobacteria,2TY4B@28211|Alphaproteobacteria 28211|Alphaproteobacteria T diguanylate cyclase - - - - - - - - - - - - GGDEF k59_378075_2 1122137.AQXF01000006_gene914 5.98e-165 474.0 COG0389@1|root,COG0389@2|Bacteria,1MUUH@1224|Proteobacteria,2TSJN@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII dinB GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0050896,GO:0051716,GO:0071496 2.7.7.7 ko:K02346 - - - - ko00000,ko01000,ko03400 - - - IMS,IMS_C k59_1054714_1 1128912.GMES_3616 5.55e-62 206.0 COG2262@1|root,COG2262@2|Bacteria,1MUA0@1224|Proteobacteria,1RN7V@1236|Gammaproteobacteria,464MZ@72275|Alteromonadaceae 1236|Gammaproteobacteria S GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis hflX GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0003924,GO:0005488,GO:0005524,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006414,GO:0006417,GO:0006464,GO:0006468,GO:0006518,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006996,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010608,GO:0016043,GO:0016310,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0018105,GO:0018193,GO:0018209,GO:0019001,GO:0019222,GO:0019538,GO:0019843,GO:0022411,GO:0030554,GO:0031323,GO:0031326,GO:0032268,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032559,GO:0032561,GO:0032790,GO:0032984,GO:0032988,GO:0034248,GO:0034641,GO:0034645,GO:0035639,GO:0036094,GO:0036211,GO:0036289,GO:0043021,GO:0043022,GO:0043023,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043603,GO:0043604,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0046777,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051246,GO:0060255,GO:0065007,GO:0071704,GO:0071826,GO:0071840,GO:0072344,GO:0080090,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903008,GO:2000112 - ko:K03665 - - - - ko00000,ko03009 - - - GTP-bdg_M,GTP-bdg_N,MMR_HSR1 k59_1166530_1 56110.Oscil6304_5443 1.17e-29 122.0 COG0515@1|root,COG0642@1|root,COG0745@1|root,COG2114@1|root,COG3899@1|root,COG0515@2|Bacteria,COG0745@2|Bacteria,COG2114@2|Bacteria,COG2205@2|Bacteria,COG3899@2|Bacteria,1GBKM@1117|Cyanobacteria,1H7D9@1150|Oscillatoriales 1117|Cyanobacteria KLT Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - AAA_16,GAF,HATPase_c,HisKA,Hpt,Pkinase,Response_reg k59_38567_1 1235279.C772_00581 1.03e-11 66.6 COG0631@1|root,COG0631@2|Bacteria,1V6K5@1239|Firmicutes,4HCDR@91061|Bacilli,26EG7@186818|Planococcaceae 91061|Bacilli T Serine threonine protein phosphatase stp - 3.1.3.16 ko:K20074 - - - - ko00000,ko01000,ko01009 - - - PP2C,PP2C_2 k59_38567_2 877424.ATWC01000016_gene129 2.22e-07 54.7 COG1716@1|root,COG1716@2|Bacteria,1V550@1239|Firmicutes,24BVK@186801|Clostridia,27P0N@186928|unclassified Lachnospiraceae 186801|Clostridia T Inner membrane component of T3SS, cytoplasmic domain - - - - - - - - - - - - FHA k59_767259_1 436308.Nmar_1652 6.29e-78 257.0 COG4257@1|root,arCOG06267@1|root,arCOG03564@2157|Archaea,arCOG06267@2157|Archaea,41S5S@651137|Thaumarchaeota 651137|Thaumarchaeota V resistance protein - - - ko:K14166 - - - - ko00000,ko02000 - - - CopC,CopD k59_1782683_1 1190606.AJYG01000179_gene1526 7.27e-13 63.5 2EG1K@1|root,339TK@2|Bacteria,1NGIP@1224|Proteobacteria,1SGRY@1236|Gammaproteobacteria,1Y1TD@135623|Vibrionales 135623|Vibrionales - - - - - - - - - - - - - - - k59_38571_1 926569.ANT_23030 2.01e-51 178.0 COG0739@1|root,COG0739@2|Bacteria 2|Bacteria M heme binding - - - - - - - - - - - - APH,Aminotran_3,Peptidase_M23 k59_1565207_1 1168065.DOK_07929 3.62e-67 213.0 COG1013@1|root,COG1013@2|Bacteria,1R5BF@1224|Proteobacteria,1RZ7Y@1236|Gammaproteobacteria,1J5GQ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C COG1013 Pyruvate ferredoxin oxidoreductase and related 2-oxoacid ferredoxin oxidoreductases, beta subunit - - 1.2.7.11,1.2.7.3 ko:K00175 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C k59_1565207_2 247633.GP2143_07474 1.47e-16 80.1 COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,1NBSJ@1224|Proteobacteria,1S0WV@1236|Gammaproteobacteria,1J5KF@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Pyruvate ferredoxin oxidoreductase and related 2-oxoacid ferredoxin oxidoreductases korA - 1.2.7.11,1.2.7.3 ko:K00174 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - PFOR_II,POR,POR_N k59_1507807_1 158500.BV97_02566 2.79e-31 118.0 COG0345@1|root,COG0345@2|Bacteria,1R5J1@1224|Proteobacteria,2TTY7@28211|Alphaproteobacteria,2K353@204457|Sphingomonadales 204457|Sphingomonadales E Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline proC - 1.5.1.2 ko:K00286 ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230 M00015 R01248,R01251,R03291,R03293 RC00054,RC00083 ko00000,ko00001,ko00002,ko01000 - - - F420_oxidored,P5CR_dimer k59_94232_1 203122.Sde_1057 1.95e-67 206.0 COG0360@1|root,COG0360@2|Bacteria,1RH82@1224|Proteobacteria,1S5VU@1236|Gammaproteobacteria,4677Q@72275|Alteromonadaceae 1236|Gammaproteobacteria J Binds together with S18 to 16S ribosomal RNA rpsF GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0019843,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0048027,GO:0070181,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02990 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011,ko03029 - - - Ribosomal_S6 k59_539943_1 1122194.AUHU01000002_gene2487 2.56e-182 511.0 COG0492@1|root,COG0492@2|Bacteria,1MV15@1224|Proteobacteria,1RMEX@1236|Gammaproteobacteria,465FC@72275|Alteromonadaceae 1236|Gammaproteobacteria C Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family trxB GO:0000166,GO:0003674,GO:0003824,GO:0004791,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0015036,GO:0016209,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0036094,GO:0042221,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0050660,GO:0050662,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0097159,GO:0097237,GO:0098754,GO:0098869,GO:1901265,GO:1901363,GO:1990748 1.8.1.9 ko:K00384 ko00450,map00450 - R02016,R03596,R09372 RC00013,RC02518,RC02873 ko00000,ko00001,ko01000 - - iPC815.YPO1374 Pyr_redox_2 k59_655160_1 1415778.JQMM01000001_gene1415 1.43e-124 361.0 COG0501@1|root,COG0501@2|Bacteria,1MUV4@1224|Proteobacteria,1RMN0@1236|Gammaproteobacteria,1J4K1@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O Belongs to the peptidase M48B family htpX GO:0003674,GO:0003824,GO:0004175,GO:0004222,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006508,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0008270,GO:0009266,GO:0009408,GO:0009628,GO:0016020,GO:0016021,GO:0016787,GO:0019538,GO:0031224,GO:0043167,GO:0043169,GO:0043170,GO:0044238,GO:0044425,GO:0044464,GO:0046872,GO:0046914,GO:0050896,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564 - ko:K03799 - M00743 - - ko00000,ko00002,ko01000,ko01002 - - - Peptidase_M48 k59_1107182_1 1096930.L284_20085 1.43e-55 191.0 COG2234@1|root,COG2234@2|Bacteria,1R56X@1224|Proteobacteria,2U2G7@28211|Alphaproteobacteria,2K2WC@204457|Sphingomonadales 204457|Sphingomonadales S Peptidase family M28 - - - - - - - - - - - - Peptidase_M28 k59_148412_1 1121468.AUBR01000052_gene1613 8.24e-19 86.7 COG1484@1|root,COG1484@2|Bacteria,1TPPI@1239|Firmicutes,24DKZ@186801|Clostridia,42FBN@68295|Thermoanaerobacterales 186801|Clostridia L IstB domain protein ATP-binding protein - - - - - - - - - - - - IstB_IS21 k59_539960_1 316407.1651595 1.3e-119 356.0 COG1626@1|root,COG1626@2|Bacteria,1MWSM@1224|Proteobacteria,1RMFP@1236|Gammaproteobacteria,3XMWX@561|Escherichia 1236|Gammaproteobacteria G Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system treA GO:0003674,GO:0003824,GO:0004553,GO:0004555,GO:0005575,GO:0005623,GO:0005975,GO:0005984,GO:0005991,GO:0005993,GO:0006950,GO:0006970,GO:0006972,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009311,GO:0009313,GO:0009628,GO:0009987,GO:0015927,GO:0016052,GO:0016787,GO:0016798,GO:0030288,GO:0030313,GO:0031975,GO:0033554,GO:0042597,GO:0044237,GO:0044238,GO:0044248,GO:0044262,GO:0044275,GO:0044464,GO:0046352,GO:0050896,GO:0051716,GO:0071214,GO:0071470,GO:0071474,GO:0071704,GO:0104004,GO:1901575 3.2.1.28 ko:K01194 ko00500,ko01100,map00500,map01100 - R00010 RC00049 ko00000,ko00001,ko00537,ko01000 - GH37 iAF1260.b1197,iB21_1397.B21_01182,iBWG_1329.BWG_1022,iECBD_1354.ECBD_2425,iECB_1328.ECB_01172,iECDH10B_1368.ECDH10B_1250,iECDH1ME8569_1439.ECDH1ME8569_1136,iECD_1391.ECD_01172,iECUMN_1333.ECUMN_1493,iETEC_1333.ETEC_1301,iEcDH1_1363.EcDH1_2451,iEcHS_1320.EcHS_A1301,iEcolC_1368.EcolC_2429,iJO1366.b1197,iJR904.b1197,iSBO_1134.SBO_3518,iY75_1357.Y75_RS06245 Trehalase k59_1394842_1 634177.GLX_07680 1.02e-101 312.0 COG1887@1|root,COG1887@2|Bacteria,1R4MQ@1224|Proteobacteria,2U1UT@28211|Alphaproteobacteria 28211|Alphaproteobacteria M Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC - - - - - - - - - - - - - k59_655178_1 1229909.NSED_06260 5.21e-133 390.0 COG0119@1|root,arCOG02092@2157|Archaea,41SBX@651137|Thaumarchaeota 651137|Thaumarchaeota E Belongs to the alpha-IPM synthase homocitrate synthase family - - 2.3.3.13 ko:K01649 ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230 M00432 R01213 RC00004,RC00470,RC02754 br01601,ko00000,ko00001,ko00002,ko01000 - - - HMGL-like,LeuA_dimer k59_378142_1 482537.XP_008567766.1 5.12e-12 64.7 COG0516@1|root,KOG2550@2759|Eukaryota,38BP6@33154|Opisthokonta,3BAD2@33208|Metazoa,3CRAZ@33213|Bilateria,487ZH@7711|Chordata,48WCU@7742|Vertebrata,3JDI4@40674|Mammalia,35BHS@314146|Euarchontoglires 33208|Metazoa F oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor GMPR GO:0003674,GO:0003824,GO:0003920,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009058,GO:0009266,GO:0009409,GO:0009628,GO:0009987,GO:0016491,GO:0016651,GO:0016657,GO:0018130,GO:0019438,GO:0034641,GO:0034654,GO:0043094,GO:0043101,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0055114,GO:0071704,GO:0072521,GO:0072522,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 1.7.1.7 ko:K00364 ko00230,map00230 - R01134 RC00457 ko00000,ko00001,ko01000 - - - IMPDH k59_1445972_1 1348908.KI518584_gene1795 2.3e-11 63.2 COG0347@1|root,COG0347@2|Bacteria,1V9Z5@1239|Firmicutes,4HJ6Z@91061|Bacilli,1ZHQA@1386|Bacillus 91061|Bacilli K Nitrogen regulatory protein P-II glnB - - ko:K04751 ko02020,map02020 - - - ko00000,ko00001 - - - P-II k59_1445972_2 1229909.NSED_09430 1.43e-99 312.0 arCOG02322@1|root,arCOG07810@1|root,arCOG02322@2157|Archaea,arCOG07810@2157|Archaea,41T0S@651137|Thaumarchaeota 651137|Thaumarchaeota N Adenylate guanylate cyclase with integral membrane sensor - - - - - - - - - - - - Guanylate_cyc,HAMP k59_1166571_1 879212.DespoDRAFT_00110 2.06e-33 127.0 COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,42MK5@68525|delta/epsilon subdivisions,2WJ3Z@28221|Deltaproteobacteria,2MI0N@213118|Desulfobacterales 28221|Deltaproteobacteria C PFAM Acyl-CoA dehydrogenase - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_1166571_2 1168065.DOK_12446 1.71e-13 68.6 COG1028@1|root,COG1028@2|Bacteria,1MUBQ@1224|Proteobacteria,1RQJT@1236|Gammaproteobacteria,1J8VW@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria IQ Belongs to the short-chain dehydrogenases reductases (SDR) family hadH2 - - - - - - - - - - - adh_short,adh_short_C2 k59_321837_1 1122137.AQXF01000003_gene2325 1.91e-123 377.0 COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MU0R@1224|Proteobacteria,2TR3C@28211|Alphaproteobacteria 28211|Alphaproteobacteria G Pyruvate phosphate dikinase ppdK - 2.7.9.1 ko:K01006 ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200 M00169,M00171,M00172,M00173 R00206 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - PEP-utilizers,PEP-utilizers_C,PPDK_N k59_716304_1 380394.Lferr_1056 1.28e-21 90.9 COG1941@1|root,COG1941@2|Bacteria,1NS0E@1224|Proteobacteria,1RW0G@1236|Gammaproteobacteria,2NCVE@225057|Acidithiobacillales 225057|Acidithiobacillales C NADH ubiquinone oxidoreductase, 20 Kd subunit - - - - - - - - - - - - Oxidored_q6 k59_716304_2 1122201.AUAZ01000024_gene803 6.75e-46 156.0 COG0543@1|root,COG0543@2|Bacteria,1R6QZ@1224|Proteobacteria,1RNK9@1236|Gammaproteobacteria,466U0@72275|Alteromonadaceae 1236|Gammaproteobacteria C Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B asrB - - ko:K16951 ko00920,ko01120,map00920,map01120 - R00858,R10146 RC00065 ko00000,ko00001 - - - DHODB_Fe-S_bind,FAD_binding_6,NAD_binding_1 k59_1565289_1 266834.SM_b20772 4.66e-38 140.0 COG1995@1|root,COG1995@2|Bacteria,1MXGJ@1224|Proteobacteria,2TUEU@28211|Alphaproteobacteria,4BCWC@82115|Rhizobiaceae 28211|Alphaproteobacteria H Pyridoxal phosphate biosynthetic protein PdxA pdxA_2 - 1.1.1.262 ko:K00097 ko00750,ko01100,map00750,map01100 M00124 R05681,R05837,R07406 RC00089,RC00675,RC01475 ko00000,ko00001,ko00002,ko01000 - - - PdxA k59_1222723_1 1385517.N800_05080 2.68e-86 273.0 COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,1RMNZ@1236|Gammaproteobacteria,1X34U@135614|Xanthomonadales 135614|Xanthomonadales I Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA acsA - 6.2.1.1 ko:K01895 ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200 M00357 R00235,R00236,R00316,R00926,R01354 RC00004,RC00012,RC00043,RC00070,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000,ko01004 - - - ACAS_N,AMP-binding,AMP-binding_C k59_429413_1 392500.Swoo_4272 3.02e-47 162.0 COG4714@1|root,COG4714@2|Bacteria,1N40I@1224|Proteobacteria,1S1R3@1236|Gammaproteobacteria 1236|Gammaproteobacteria S membrane-anchored protein conserved in bacteria - - - - - - - - - - - - DUF2167 k59_263301_1 1178825.ALIH01000005_gene204 1.28e-40 143.0 COG0589@1|root,COG0589@2|Bacteria,4NHBB@976|Bacteroidetes,1HYAY@117743|Flavobacteriia 976|Bacteroidetes T Universal stress protein - - - - - - - - - - - - Usp k59_1618294_1 1122137.AQXF01000003_gene2171 2.05e-43 148.0 COG1218@1|root,COG1218@2|Bacteria,1N0GY@1224|Proteobacteria,2TT7B@28211|Alphaproteobacteria 28211|Alphaproteobacteria P 3'(2'),5'-bisphosphate nucleotidase cysQ - 3.1.3.7 ko:K01082 ko00920,ko01100,ko01120,ko01130,map00920,map01100,map01120,map01130 - R00188,R00508 RC00078 ko00000,ko00001,ko01000,ko03016 - - - Inositol_P k59_1618294_2 1056820.KB900700_gene1133 1.52e-27 107.0 COG4094@1|root,COG4094@2|Bacteria,1RDHB@1224|Proteobacteria,1S78U@1236|Gammaproteobacteria,2PPQC@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria S NnrU protein nnrU - - - - - - - - - - - NnrU k59_1275766_1 1231190.NA8A_20507 1.15e-08 63.2 COG2902@1|root,COG2902@2|Bacteria,1MXNV@1224|Proteobacteria,2TS89@28211|Alphaproteobacteria,43HQR@69277|Phyllobacteriaceae 28211|Alphaproteobacteria E Dehydrogenase gdhB GO:0003674,GO:0003824,GO:0004352,GO:0004353,GO:0008150,GO:0008152,GO:0016491,GO:0016638,GO:0016639,GO:0055114 1.4.1.2 ko:K15371 ko00220,ko00250,ko00430,ko00910,ko01100,map00220,map00250,map00430,map00910,map01100 - R00243 RC00006,RC02799 ko00000,ko00001,ko01000 - - - Bac_GDH k59_655235_1 1401328.P856_638 3.53e-75 240.0 COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,2TRYI@28211|Alphaproteobacteria,2JPKJ@204441|Rhodospirillales 204441|Rhodospirillales C COG0277 FAD FMN-containing dehydrogenases - - 1.1.2.4 ko:K00102 ko00620,map00620 - R00197 RC00044 ko00000,ko00001,ko01000 - - - FAD-oxidase_C,FAD_binding_4 k59_1446027_1 500635.MITSMUL_04171 4.89e-45 159.0 COG4965@1|root,COG4965@2|Bacteria,1UZ3V@1239|Firmicutes,4H3YR@909932|Negativicutes 909932|Negativicutes U Type II secretion system - - - ko:K12510 - - - - ko00000,ko02044 - - - T2SSF k59_1446027_2 685727.REQ_18430 8.64e-48 169.0 COG2064@1|root,COG2064@2|Bacteria,2GK7B@201174|Actinobacteria 201174|Actinobacteria NU Type ii secretion system - - - ko:K12511 - - - - ko00000,ko02044 - - - T2SSF k59_1394893_1 1046627.BZARG_329 2.4e-83 254.0 COG2227@1|root,COG2227@2|Bacteria,4NK5C@976|Bacteroidetes,1HZ6H@117743|Flavobacteriia 976|Bacteroidetes H Methyltransferase domain - - - - - - - - - - - - Methyltransf_23 k59_94283_1 517418.Ctha_1616 1.28e-116 352.0 COG1858@1|root,COG1858@2|Bacteria,1FDVA@1090|Chlorobi 1090|Chlorobi C PFAM Di-haem cytochrome c peroxidase - - 1.11.1.5 ko:K00428 - - - - ko00000,ko01000 - - - CCP_MauG,Cytochrom_C k59_1166610_2 1250232.JQNJ01000001_gene2074 1.81e-07 55.1 COG3279@1|root,COG3279@2|Bacteria,4NIXU@976|Bacteroidetes,1I2CK@117743|Flavobacteriia 976|Bacteroidetes KT Chemotaxis protein CheY - - - - - - - - - - - - LytTR,Response_reg k59_886649_1 83406.HDN1F_01170 2.34e-40 145.0 COG1216@1|root,COG1216@2|Bacteria,1RBVM@1224|Proteobacteria,1S2YU@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Glycosyl transferase family 2 - - - - - - - - - - - - Glycos_transf_2 k59_38661_1 977880.RALTA_A2531 1.42e-96 292.0 COG0538@1|root,COG0538@2|Bacteria,1MW3J@1224|Proteobacteria,2VHVD@28216|Betaproteobacteria,1K0EF@119060|Burkholderiaceae 28216|Betaproteobacteria C Isocitrate dehydrogenase icd GO:0003674,GO:0003824,GO:0003862,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.42 ko:K00031 ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146 M00009,M00010,M00173,M00740 R00267,R00268,R01899 RC00001,RC00084,RC00114,RC00626,RC02801 br01601,ko00000,ko00001,ko00002,ko01000 - - - Iso_dh k59_716338_1 1348657.M622_02715 2.12e-22 94.7 COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,2VNEF@28216|Betaproteobacteria 28216|Betaproteobacteria I acyl-CoA dehydrogenase - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_716338_2 309801.trd_1211 1.07e-30 111.0 COG1975@1|root,COG1975@2|Bacteria,2G6Z8@200795|Chloroflexi,27YDJ@189775|Thermomicrobia 189775|Thermomicrobia O XdhC and CoxI family - - - - - - - - - - - - XdhC_CoxI k59_429445_1 1541065.JRFE01000047_gene3308 2.93e-58 191.0 2B3HK@1|root,31W6K@2|Bacteria,1GDJP@1117|Cyanobacteria 1117|Cyanobacteria - - - - - - - - - - - - - - - k59_429445_2 1541065.JRFE01000047_gene3307 4.72e-24 98.2 2DBRK@1|root,2ZAME@2|Bacteria,1GAT0@1117|Cyanobacteria 1117|Cyanobacteria - - - - - - - - - - - - - - - k59_321873_1 570952.ATVH01000017_gene1762 5.54e-47 158.0 COG1765@1|root,COG1765@2|Bacteria,1MWPR@1224|Proteobacteria,2U1VW@28211|Alphaproteobacteria,2JUAQ@204441|Rhodospirillales 204441|Rhodospirillales O OsmC-like protein - - - - - - - - - - - - OsmC k59_540042_1 1229909.NSED_04715 3.28e-05 45.1 28HMW@1|root,2N5MZ@2157|Archaea,41T97@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_540042_2 228410.NE0095 0.000477 43.9 COG0516@1|root,COG0517@1|root,COG0516@2|Bacteria,COG0517@2|Bacteria,1MUJM@1224|Proteobacteria,2VH9X@28216|Betaproteobacteria,371UD@32003|Nitrosomonadales 28216|Betaproteobacteria F Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth guaB - 1.1.1.205 ko:K00088 ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 M00050 R01130,R08240 RC00143,RC02207 ko00000,ko00001,ko00002,ko01000,ko04147 - - - CBS,IMPDH,NMO k59_716365_1 1122137.AQXF01000001_gene3230 5.62e-80 246.0 COG0313@1|root,COG0313@2|Bacteria,1MU0E@1224|Proteobacteria,2TR14@28211|Alphaproteobacteria 28211|Alphaproteobacteria H Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA rsmI - 2.1.1.198 ko:K07056 - - - - ko00000,ko01000,ko03009 - - - TP_methylase k59_1222759_1 1469245.JFBG01000072_gene78 1.11e-89 288.0 COG0653@1|root,COG0653@2|Bacteria,1MUJZ@1224|Proteobacteria,1RM9M@1236|Gammaproteobacteria,1WWZC@135613|Chromatiales 135613|Chromatiales U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane secA - - ko:K03070 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4 - - SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW k59_1618318_1 742723.HMPREF9477_00236 2.87e-06 53.9 COG0745@1|root,COG0745@2|Bacteria,1TPQG@1239|Firmicutes,248Z4@186801|Clostridia,27IU2@186928|unclassified Lachnospiraceae 186801|Clostridia T Transcriptional regulatory protein, C terminal - - - - - - - - - - - - Response_reg,Trans_reg_C k59_1507893_1 571166.KI421509_gene3405 5.75e-82 244.0 2BDUH@1|root,302AN@2|Bacteria,1RF2Q@1224|Proteobacteria,2U8FX@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Glutathione-dependent formaldehyde-activating enzyme - - - - - - - - - - - - GFA k59_1565331_1 1163408.UU9_08063 1.89e-77 239.0 COG0152@1|root,COG0152@2|Bacteria,1MUR9@1224|Proteobacteria,1RNNY@1236|Gammaproteobacteria,1X3PE@135614|Xanthomonadales 135614|Xanthomonadales F Belongs to the SAICAR synthetase family purC GO:0003674,GO:0003824,GO:0004639,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006188,GO:0006189,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.2.6 ko:K01923 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04591 RC00064,RC00162 ko00000,ko00001,ko00002,ko01000 - - - SAICAR_synt k59_716370_1 1172188.KB911820_gene2633 1.37e-87 278.0 COG2132@1|root,COG2132@2|Bacteria,2GMJ4@201174|Actinobacteria,4FG4H@85021|Intrasporangiaceae 201174|Actinobacteria Q Multicopper oxidase - - 1.3.3.5 ko:K08100 ko00860,ko01110,map00860,map01110 - R02394 RC01983 ko00000,ko00001,ko01000 - - - Cu-oxidase,Cu-oxidase_2,Cu-oxidase_3 k59_826425_1 1122137.AQXF01000006_gene802 3.68e-94 287.0 COG1301@1|root,COG1301@2|Bacteria,1MU0Q@1224|Proteobacteria,2TRET@28211|Alphaproteobacteria 28211|Alphaproteobacteria C Responsible for the transport of dicarboxylates such as succinate, fumarate, and malate - - - - - - - - - - - - SDF k59_1565346_1 86106.I862_02820 2.62e-54 193.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2TQT0@28211|Alphaproteobacteria,47EX4@766|Rickettsiales 766|Rickettsiales V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family acrD - - ko:K18138,ko:K18989 ko01501,ko01503,map01501,map01503 M00647,M00699,M00718,M00720 - - ko00000,ko00001,ko00002,ko01504,ko02000 2.A.6.2,2.A.6.2.30 - - ACR_tran k59_38701_1 1144305.PMI02_00541 7.27e-75 230.0 COG0491@1|root,COG0491@2|Bacteria,1MU8Q@1224|Proteobacteria,2TSVS@28211|Alphaproteobacteria,2K0DY@204457|Sphingomonadales 204457|Sphingomonadales S Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid gloB - 3.1.2.6 ko:K01069 ko00620,map00620 - R01736 RC00004,RC00137 ko00000,ko00001,ko01000 - - - HAGH_C,Lactamase_B k59_148579_1 1088721.NSU_1157 4.27e-32 122.0 COG0275@1|root,COG0275@2|Bacteria,1MUT4@1224|Proteobacteria,2TRQA@28211|Alphaproteobacteria,2K178@204457|Sphingomonadales 204457|Sphingomonadales J Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA rsmH - 2.1.1.199 ko:K03438 - - - - ko00000,ko01000,ko03009 - - - Methyltransf_5 k59_148579_2 1088721.NSU_1155 5.55e-22 90.1 2AK00@1|root,32PGE@2|Bacteria,1NEPB@1224|Proteobacteria,2UFQJ@28211|Alphaproteobacteria,2K6PN@204457|Sphingomonadales 204457|Sphingomonadales - - - - - - - - - - - - - - - k59_603443_1 436308.Nmar_1285 7.74e-11 62.4 COG0715@1|root,arCOG01803@2157|Archaea,41SG5@651137|Thaumarchaeota 651137|Thaumarchaeota P TIGRFAM ABC transporter, substrate-binding protein, aliphatic sulfonates family - - - ko:K02051 - M00188 - - ko00000,ko00002,ko02000 3.A.1.16,3.A.1.17 - - NMT1_2 k59_603443_2 436308.Nmar_1286 1.11e-50 171.0 COG0137@1|root,arCOG00112@2157|Archaea,41S6K@651137|Thaumarchaeota 651137|Thaumarchaeota E Belongs to the argininosuccinate synthase family. Type 1 subfamily argG - 6.3.4.5 ko:K01940 ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418 M00029,M00844,M00845 R01954 RC00380,RC00629 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Arginosuc_synth k59_1166653_1 485913.Krac_9327 1.14e-95 300.0 COG3547@1|root,COG3547@2|Bacteria 2|Bacteria L Transposase (IS116 IS110 IS902 family) - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_1275833_1 335283.Neut_0201 3.25e-118 362.0 COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,2VIAU@28216|Betaproteobacteria,3727H@32003|Nitrosomonadales 28216|Betaproteobacteria O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner lon - 3.4.21.53 ko:K01338 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - AAA,LON_substr_bdg,Lon_C k59_321914_2 1380394.JADL01000014_gene190 3.06e-12 63.5 COG3791@1|root,COG3791@2|Bacteria,1N6S5@1224|Proteobacteria,2UG0P@28211|Alphaproteobacteria,2JT7N@204441|Rhodospirillales 204441|Rhodospirillales S Glutathione-dependent formaldehyde-activating enzyme - - - - - - - - - - - - GFA k59_1782818_1 436308.Nmar_0046 2.67e-50 161.0 arCOG08817@1|root,arCOG08817@2157|Archaea,41SV5@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_263363_1 930166.CD58_29230 4.89e-97 298.0 COG3288@1|root,COG3288@2|Bacteria,1MVXU@1224|Proteobacteria,1RN23@1236|Gammaproteobacteria 1236|Gammaproteobacteria C The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane pntAA - 1.6.1.2 ko:K00324 ko00760,ko01100,map00760,map01100 - R00112 RC00001 ko00000,ko00001,ko01000 - - - AlaDh_PNT_C,AlaDh_PNT_N k59_1166663_1 350058.Mvan_3415 3.93e-15 80.1 COG2267@1|root,COG3710@1|root,COG2267@2|Bacteria,COG3710@2|Bacteria,2I419@201174|Actinobacteria,234R8@1762|Mycobacteriaceae 201174|Actinobacteria IK Alpha beta hydrolase - - - - - - - - - - - - Abhydrolase_1,Trans_reg_C k59_38713_1 1148.1653166 1.66e-44 156.0 COG1305@1|root,COG1305@2|Bacteria,1G2WU@1117|Cyanobacteria,1H6FT@1142|Synechocystis 1117|Cyanobacteria E Bacterial transglutaminase-like N-terminal region - - - - - - - - - - - - Bact_transglu_N,Transglut_core k59_655288_1 1121935.AQXX01000144_gene4415 3.66e-84 268.0 COG0161@1|root,COG0161@2|Bacteria,1MU2N@1224|Proteobacteria,1RNW9@1236|Gammaproteobacteria,1XH5I@135619|Oceanospirillales 135619|Oceanospirillales H Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family - - - - - - - - - - - - Aminotran_3 k59_485111_1 452662.SJA_C1-21120 1.49e-39 155.0 COG1629@1|root,COG4774@1|root,COG1629@2|Bacteria,COG4774@2|Bacteria,1NMCN@1224|Proteobacteria 1224|Proteobacteria P COG1629 Outer membrane receptor proteins, mostly Fe transport - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_1446140_1 232346.JHQL01000003_gene254 3.72e-13 69.7 COG0154@1|root,COG0154@2|Bacteria,1MUVQ@1224|Proteobacteria,1RP7E@1236|Gammaproteobacteria,1XHA4@135619|Oceanospirillales 135619|Oceanospirillales J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) gatA - 6.3.5.6,6.3.5.7 ko:K02433 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - Amidase k59_1446140_2 1288826.MSNKSG1_09088 2.84e-36 126.0 COG0721@1|root,COG0721@2|Bacteria,1MZQP@1224|Proteobacteria,1S8VY@1236|Gammaproteobacteria,467YW@72275|Alteromonadaceae 1236|Gammaproteobacteria J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) gatC - 6.3.5.6,6.3.5.7 ko:K02435 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - Glu-tRNAGln k59_206211_1 330214.NIDE3237 1.58e-172 513.0 COG0243@1|root,COG0243@2|Bacteria 2|Bacteria C molybdopterin cofactor binding ddhA GO:0005575,GO:0005623,GO:0042597,GO:0044464 1.17.99.2,1.7.5.1,1.8.2.4 ko:K00370,ko:K10700,ko:K16964,ko:K17050 ko00642,ko00910,ko00920,ko01100,ko01120,ko01220,ko02020,map00642,map00910,map00920,map01100,map01120,map01220,map02020 M00529,M00530,M00804 R00798,R01106,R05745,R09497,R09500 RC00275,RC02555,RC02812 ko00000,ko00001,ko00002,ko01000,ko02000 5.A.3.1,5.A.3.8,5.A.3.9 - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding,TAT_signal k59_886721_1 436308.Nmar_0048 3.26e-101 306.0 COG0301@1|root,arCOG00038@2157|Archaea,41ST5@651137|Thaumarchaeota 651137|Thaumarchaeota H Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS - - - - - - - - - - - - - k59_886721_2 436308.Nmar_0047 1.04e-69 222.0 COG1819@1|root,arCOG01393@2157|Archaea,41SZK@651137|Thaumarchaeota 651137|Thaumarchaeota G Glycosyl transferase family 1 - - - - - - - - - - - - - k59_1332845_1 207559.Dde_2849 6.04e-88 274.0 COG3039@1|root,COG3039@2|Bacteria,1MVTU@1224|Proteobacteria,42Q03@68525|delta/epsilon subdivisions,2WMFQ@28221|Deltaproteobacteria,2MBAU@213115|Desulfovibrionales 28221|Deltaproteobacteria L Transposase domain (DUF772) - - - ko:K07481 - - - - ko00000 - - - DDE_Tnp_1,DDE_Tnp_1_6,DUF772 k59_716442_1 401526.TcarDRAFT_0338 2.17e-92 281.0 COG0330@1|root,COG0330@2|Bacteria,1W712@1239|Firmicutes,4H8TU@909932|Negativicutes 909932|Negativicutes O prohibitin homologues - - - - - - - - - - - - Band_7 k59_321954_1 1414719.CBYN010000001_gene907 2.02e-19 90.1 COG1842@1|root,COG1842@2|Bacteria,2GJGD@201174|Actinobacteria,22KB8@1653|Corynebacteriaceae 201174|Actinobacteria KT Phage shock protein A (IM30), suppresses sigma54-dependent transcription pspA GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044464,GO:0071944 - ko:K03969 - - - - ko00000 - - - PspA_IM30 k59_826488_1 1122194.AUHU01000002_gene2647 5.64e-91 276.0 COG0631@1|root,COG0631@2|Bacteria,1R7UF@1224|Proteobacteria,1RQUV@1236|Gammaproteobacteria,46746@72275|Alteromonadaceae 1236|Gammaproteobacteria T Serine/threonine phosphatases, family 2C, catalytic domain - - 3.1.3.16 ko:K20074 - - - - ko00000,ko01000,ko01009 - - - PP2C,PP2C_2 k59_1447349_3 314260.PB2503_10259 6.43e-34 128.0 COG0477@1|root,COG2814@2|Bacteria,1QUD1@1224|Proteobacteria,2TWB1@28211|Alphaproteobacteria 28211|Alphaproteobacteria EGP COG0477 Permeases of the major facilitator superfamily - - - - - - - - - - - - MFS_1 k59_1395941_1 349124.Hhal_0479 2.13e-32 129.0 COG1419@1|root,COG1419@2|Bacteria,1MUQW@1224|Proteobacteria,1RMUU@1236|Gammaproteobacteria,1WXF1@135613|Chromatiales 135613|Chromatiales N PFAM GTP-binding signal recognition particle SRP54 G- domain - - - ko:K02404 - - - - ko00000,ko02035 - - - SRP54 k59_1619336_2 177439.DP1112 7.24e-40 138.0 COG0250@1|root,COG0250@2|Bacteria,1MU14@1224|Proteobacteria,42MPQ@68525|delta/epsilon subdivisions,2WMP6@28221|Deltaproteobacteria,2MHS4@213118|Desulfobacterales 28221|Deltaproteobacteria K Participates in transcription elongation, termination and antitermination nusG - - ko:K02601 - - - - ko00000,ko03009,ko03021 - - - KOW,NusG k59_938794_1 1122137.AQXF01000004_gene1409 5.02e-202 582.0 COG0072@1|root,COG0072@2|Bacteria,1MWKS@1224|Proteobacteria,2TQV8@28211|Alphaproteobacteria 28211|Alphaproteobacteria J Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily pheT GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016070,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494 6.1.1.20 ko:K01890 ko00970,map00970 M00359,M00360 R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - B3_4,B5,FDX-ACB,tRNA_bind k59_1570614_2 653733.Selin_1132 8.31e-24 91.7 COG0607@1|root,32YCZ@2|Bacteria 2|Bacteria P Sulfurtransferase ygaP - - - - - - - - - - - DUF2892 k59_1570614_3 1282876.BAOK01000001_gene2772 1.26e-13 71.6 COG1033@1|root,COG1033@2|Bacteria,1MUE1@1224|Proteobacteria,2TRI9@28211|Alphaproteobacteria,4BRV4@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria S MMPL family MA20_16090 - - ko:K07003 - - - - ko00000 - - - MMPL k59_661174_1 243160.BMA1850 3.73e-40 141.0 COG1595@1|root,COG1595@2|Bacteria,1R9WC@1224|Proteobacteria,2VQ28@28216|Betaproteobacteria,1K3KU@119060|Burkholderiaceae 28216|Betaproteobacteria K RNA polymerase sigE - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 k59_1112790_1 565045.NOR51B_1645 3.56e-101 311.0 COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,1NBSJ@1224|Proteobacteria,1S0WV@1236|Gammaproteobacteria,1J5KF@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Pyruvate ferredoxin oxidoreductase and related 2-oxoacid ferredoxin oxidoreductases korA - 1.2.7.11,1.2.7.3 ko:K00174 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - PFOR_II,POR,POR_N k59_153980_1 1218084.BBJK01000019_gene2042 1.66e-07 52.8 COG0625@1|root,COG0625@2|Bacteria,1RA4Y@1224|Proteobacteria,2VKEU@28216|Betaproteobacteria,1K2Y6@119060|Burkholderiaceae 28216|Betaproteobacteria G maleylacetoacetate isomerase maiA - 5.2.1.2,5.2.1.4 ko:K01800,ko:K01801 ko00350,ko00643,ko01100,ko01120,map00350,map00643,map01100,map01120 M00044 R03181,R03868 RC00867 ko00000,ko00001,ko00002,ko01000 - - - GST_C,GST_C_2,GST_C_3,GST_N,GST_N_3 k59_153980_2 1461694.ATO9_19335 1.01e-68 218.0 COG1073@1|root,COG1073@2|Bacteria,1MXJ3@1224|Proteobacteria,2TVHP@28211|Alphaproteobacteria 28211|Alphaproteobacteria E hydrolases or acyltransferases, alpha beta hydrolase superfamily - - - - - - - - - - - - Abhydrolase_6,DUF1100,Peptidase_S9 k59_831529_1 1208321.D104_08275 1.92e-41 153.0 COG2021@1|root,COG5517@1|root,COG2021@2|Bacteria,COG5517@2|Bacteria,1RDEH@1224|Proteobacteria,1T1N9@1236|Gammaproteobacteria,1XKDH@135619|Oceanospirillales 135619|Oceanospirillales E Serine aminopeptidase, S33 - - - - - - - - - - - - Abhydrolase_6 k59_831529_2 1122137.AQXF01000004_gene1798 1.89e-13 72.0 COG2911@1|root,COG2931@1|root,COG2911@2|Bacteria,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,2TRVY@28211|Alphaproteobacteria 28211|Alphaproteobacteria Q COG2931 RTX toxins and related Ca2 -binding proteins - - - ko:K07004 - - - - ko00000 - - - Calx-beta,DUF4347,HemolysinCabind,P_proprotein,Peptidase_M10,Peptidase_M10_C,Peptidase_S8 k59_268852_1 373903.Hore_11920 1.97e-40 147.0 COG1058@1|root,COG1546@1|root,COG1058@2|Bacteria,COG1546@2|Bacteria,1TQ1N@1239|Firmicutes,249WC@186801|Clostridia,3WAKZ@53433|Halanaerobiales 186801|Clostridia S TIGRFAM competence damage-inducible protein CinA cinA - 3.5.1.42 ko:K03742,ko:K03743 ko00760,map00760 - R02322 RC00100 ko00000,ko00001,ko01000 - - - CinA,MoCF_biosynth k59_1513122_2 1229909.NSED_07470 6.95e-74 225.0 arCOG11327@1|root,arCOG11327@2157|Archaea,41T5V@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1788118_1 926569.ANT_06600 1.34e-30 124.0 COG2203@1|root,COG5002@1|root,COG2203@2|Bacteria,COG5002@2|Bacteria,2G7NF@200795|Chloroflexi 200795|Chloroflexi T histidine kinase A domain protein - - - - - - - - - - - - GAF_2,HATPase_c,HisKA k59_1788119_1 158500.BV97_00441 8.38e-105 305.0 COG0302@1|root,COG0302@2|Bacteria,1MY3N@1224|Proteobacteria,2TSZI@28211|Alphaproteobacteria,2K0QV@204457|Sphingomonadales 204457|Sphingomonadales H GTP cyclohydrolase folE - 3.5.4.16 ko:K01495 ko00790,ko01100,map00790,map01100 M00126,M00841,M00842,M00843 R00428,R04639,R05046,R05048 RC00263,RC00294,RC00323,RC00945,RC01188 ko00000,ko00001,ko00002,ko01000 - - - GTP_cyclohydroI k59_1788119_2 702113.PP1Y_AT29521 7.23e-15 73.9 COG1502@1|root,COG1502@2|Bacteria,1MV8I@1224|Proteobacteria,2TTM4@28211|Alphaproteobacteria,2K0U2@204457|Sphingomonadales 204457|Sphingomonadales I COG1502 Phosphatidylserine phosphatidylglycerophosphate cardiolipi n synthases and related enzymes - - - - - - - - - - - - PLDc,PLDc_2 k59_661188_1 1168065.DOK_00430 7.71e-40 157.0 COG1629@1|root,COG4771@2|Bacteria 2|Bacteria P TonB-dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_490553_1 398525.KB900701_gene2922 1.09e-124 360.0 COG1348@1|root,COG1348@2|Bacteria,1MVTE@1224|Proteobacteria,2TSKC@28211|Alphaproteobacteria,3JQXH@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria P The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components the iron protein and the molybdenum-iron protein nifH - 1.18.6.1 ko:K02588 ko00625,ko00910,ko01100,ko01120,map00625,map00910,map01100,map01120 M00175 R05185,R05496 RC00002,RC01395,RC02891 ko00000,ko00001,ko00002,ko01000 - - - Fer4_NifH k59_1623241_1 1056820.KB900663_gene3857 6.38e-41 145.0 COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,1RMWA@1236|Gammaproteobacteria,2PN7C@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria L helicase superfamily c-terminal domain rhlB GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009056,GO:0009057,GO:0009987,GO:0010501,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019439,GO:0019904,GO:0034641,GO:0034655,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0070035,GO:0071704,GO:0090304,GO:0097718,GO:0140098,GO:1901360,GO:1901361,GO:1901575 3.6.4.13 ko:K03732 ko03018,map03018 M00394 - - ko00000,ko00001,ko00002,ko01000,ko03019 - - - DEAD,Helicase_C,RhlB k59_1623241_2 1415778.JQMM01000001_gene262 3.04e-29 112.0 COG2981@1|root,COG2981@2|Bacteria,1MVFT@1224|Proteobacteria,1RMQT@1236|Gammaproteobacteria,1J5RJ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria U High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway cysZ GO:0000096,GO:0000097,GO:0000103,GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006082,GO:0006520,GO:0006534,GO:0006790,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0008150,GO:0008152,GO:0008271,GO:0008272,GO:0008324,GO:0008509,GO:0008512,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009675,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015103,GO:0015116,GO:0015291,GO:0015293,GO:0015294,GO:0015295,GO:0015296,GO:0015318,GO:0015672,GO:0015698,GO:0016020,GO:0016021,GO:0016053,GO:0019344,GO:0019752,GO:0022804,GO:0022857,GO:0022890,GO:0031224,GO:0031226,GO:0034220,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044425,GO:0044459,GO:0044464,GO:0046394,GO:0051179,GO:0051234,GO:0055085,GO:0071704,GO:0071944,GO:0072348,GO:0098655,GO:0098656,GO:0098660,GO:0098661,GO:0098662,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1901682,GO:1902358,GO:1902600 - ko:K06203 - - - - ko00000 - - iJR904.b2413,iYL1228.KPN_02760 EI24 k59_383624_1 1288494.EBAPG3_21040 3.69e-67 234.0 COG1074@1|root,COG1074@2|Bacteria,1MUTF@1224|Proteobacteria,2VHNB@28216|Betaproteobacteria,371VU@32003|Nitrosomonadales 28216|Betaproteobacteria L Belongs to the helicase family. UvrD subfamily addA - 3.1.11.5 ko:K03582 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - PDDEXK_1,UvrD-helicase,UvrD_C k59_383625_1 1122139.KB907865_gene1478 1.92e-34 134.0 COG0477@1|root,COG0477@2|Bacteria,1MWUR@1224|Proteobacteria,1T1TP@1236|Gammaproteobacteria,1XK1J@135619|Oceanospirillales 135619|Oceanospirillales EGP Major Facilitator Superfamily - - - ko:K08169 - - - - ko00000,ko02000 2.A.1.3.17 - - MFS_1 k59_1281517_1 199310.c4336 2.79e-22 91.7 COG2200@1|root,COG2200@2|Bacteria,1N1RI@1224|Proteobacteria,1RQ03@1236|Gammaproteobacteria,3XMQ2@561|Escherichia 1236|Gammaproteobacteria T A bis-(3'-5') cyclic diguanylic acid (c-di-GMP) phosphodiesterase involved in regulating the levels of c-di-GMP that control cell motility (the flagella) and adhesion (adhesive curli fimbriae). The YhjH effect on flagella is controlled via the c-di-GMP-binding flagellar brake protein YcgR, however curli expression is not regulated via YcgR. Forms a network with different diguanylate cyclases (DosC, YeaJ, YedQ, YegE have been identified) to regulate c-di-GMP levels. Flagellar activity is high at low c-di-GMP levels whereas curli fimbria are induced at high c-di-GMP levels. Cyclic-di-GMP is a second messenger which controls cell surface-associated traits in bacteria yhjH GO:0003674,GO:0003824,GO:0008081,GO:0008150,GO:0016787,GO:0016788,GO:0032879,GO:0040012,GO:0042578,GO:0050789,GO:0050794,GO:0051270,GO:0065007,GO:0071111,GO:1902021,GO:2000145 3.1.4.52 ko:K21086 ko02026,map02026 - - - ko00000,ko00001,ko01000 - - - EAL k59_1281517_2 511145.b3526 3.47e-99 294.0 COG0524@1|root,COG0524@2|Bacteria,1MVG2@1224|Proteobacteria,1RNH5@1236|Gammaproteobacteria,3XMJV@561|Escherichia 1236|Gammaproteobacteria G 2-dehydro-3-deoxygluconokinase activity kdgK GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006063,GO:0006064,GO:0006082,GO:0006793,GO:0006796,GO:0006950,GO:0006974,GO:0008144,GO:0008150,GO:0008152,GO:0008673,GO:0009056,GO:0009987,GO:0016052,GO:0016054,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017076,GO:0019200,GO:0019585,GO:0019586,GO:0019698,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0033554,GO:0035639,GO:0036094,GO:0042839,GO:0042840,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044262,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046395,GO:0046396,GO:0046397,GO:0046835,GO:0050896,GO:0051716,GO:0071704,GO:0072329,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901575 2.7.1.45 ko:K00874 ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200 M00061,M00308,M00631 R01541 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - iAPECO1_1312.APECO1_2922,iPC815.YPO3990,iUTI89_1310.UTI89_C4058 PfkB k59_1623244_1 1469607.KK073768_gene2118 3.93e-08 61.6 COG3210@1|root,COG3210@2|Bacteria,1G0EK@1117|Cyanobacteria,1HQID@1161|Nostocales 1117|Cyanobacteria U TIGRFAM filamentous hemagglutinin family N-terminal domain - - - - - - - - - - - - Haemagg_act k59_1112809_1 1123400.KB904759_gene2083 9.11e-10 58.5 COG0655@1|root,COG0655@2|Bacteria,1RAP5@1224|Proteobacteria,1S3B1@1236|Gammaproteobacteria,462P9@72273|Thiotrichales 72273|Thiotrichales S COG0655 Multimeric flavodoxin WrbA - - - - - - - - - - - - - k59_99466_1 1336803.PHEL49_0557 5.81e-12 66.6 2DB82@1|root,2Z7PX@2|Bacteria,4NEW5@976|Bacteroidetes,1HXZZ@117743|Flavobacteriia,3VW8Q@52959|Polaribacter 976|Bacteroidetes - - - - - - - - - - - - - - Beta_helix k59_99466_2 991.IW20_08950 1.23e-32 124.0 COG0112@1|root,COG0112@2|Bacteria,4NE30@976|Bacteroidetes,1HXUW@117743|Flavobacteriia,2NSQJ@237|Flavobacterium 976|Bacteroidetes E Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism glyA - 2.1.2.1 ko:K00600 ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523 M00140,M00141,M00346,M00532 R00945,R09099 RC00022,RC00112,RC01583,RC02958 ko00000,ko00001,ko00002,ko01000 - - - SHMT k59_661206_1 1229909.NSED_09410 1.69e-113 335.0 COG0520@1|root,arCOG00065@2157|Archaea,41SYH@651137|Thaumarchaeota 651137|Thaumarchaeota E Aminotransferase class-V - - 2.8.1.7,4.4.1.16 ko:K11717 ko00450,ko01100,map00450,map01100 - R03599,R11528 RC00961,RC01789,RC02313 ko00000,ko00001,ko01000 - - - Aminotran_5 k59_268867_1 1122137.AQXF01000002_gene137 6.75e-102 298.0 COG0233@1|root,COG0233@2|Bacteria,1N66T@1224|Proteobacteria,2U5B2@28211|Alphaproteobacteria 28211|Alphaproteobacteria J Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another frr GO:0002181,GO:0002184,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0022411,GO:0032984,GO:0034641,GO:0034645,GO:0043021,GO:0043023,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044464,GO:0044877,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576 - ko:K02838 - - - - ko00000,ko03012 - - - RRF k59_891901_2 1415778.JQMM01000001_gene820 1.47e-25 105.0 COG0471@1|root,COG0569@1|root,COG0471@2|Bacteria,COG0569@2|Bacteria,1MU0K@1224|Proteobacteria,1RMI1@1236|Gammaproteobacteria,1J4XJ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P COG0471 Di- and tricarboxylate transporters - - - - - - - - - - - - CitMHS,TrkA_C k59_1400609_1 1248760.ANFZ01000006_gene2289 1.17e-16 84.3 COG1629@1|root,COG4774@1|root,COG1629@2|Bacteria,COG4774@2|Bacteria,1R5EH@1224|Proteobacteria,2U45J@28211|Alphaproteobacteria,2KEKX@204457|Sphingomonadales 204457|Sphingomonadales P TonB dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_383658_2 1038862.KB893806_gene3182 2.28e-42 150.0 COG2203@1|root,COG2203@2|Bacteria,1QWV5@1224|Proteobacteria,2TX6E@28211|Alphaproteobacteria,3JXPX@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria T Gaf domain - - - - - - - - - - - - - k59_661232_2 1046724.KB889875_gene1714 2.41e-23 98.6 COG0583@1|root,COG0583@2|Bacteria,1MZTA@1224|Proteobacteria,1RN7R@1236|Gammaproteobacteria,466EN@72275|Alteromonadaceae 1236|Gammaproteobacteria K Transcriptional regulator yhaJ GO:0001130,GO:0001216,GO:0003674,GO:0003700,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031334,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043254,GO:0044087,GO:0044089,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0045893,GO:0045935,GO:0046483,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051128,GO:0051130,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901576,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2000142,GO:2000144,GO:2001141 - - - - - - - - - - HTH_1,LysR_substrate k59_1678184_1 436308.Nmar_1687 1.09e-11 61.6 COG1781@1|root,arCOG04229@2157|Archaea,41SJT@651137|Thaumarchaeota 651137|Thaumarchaeota F Involved in allosteric regulation of aspartate carbamoyltransferase pyrI - - ko:K00610 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R01397 RC00064,RC02850 ko00000,ko00001,ko00002 - - - PyrI,PyrI_C k59_1678184_2 1229909.NSED_08980 1.97e-75 233.0 COG0540@1|root,arCOG00911@2157|Archaea,41S6H@651137|Thaumarchaeota 651137|Thaumarchaeota F aspartate carbamoyltransferase pyrB - 2.1.3.2 ko:K00609 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R01397 RC00064,RC02850 ko00000,ko00001,ko00002,ko01000 - - - OTCace,OTCace_N k59_722025_1 631362.Thi970DRAFT_00910 9.37e-159 463.0 COG0443@1|root,COG0443@2|Bacteria,1MVEN@1224|Proteobacteria,1RMDD@1236|Gammaproteobacteria,1WVW2@135613|Chromatiales 135613|Chromatiales O Heat shock 70 kDa protein dnaK - - ko:K04043 ko03018,ko04212,ko05152,map03018,map04212,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 1.A.33.1 - - HSP70 k59_545860_1 1121396.KB893065_gene1609 6.48e-60 208.0 COG4249@1|root,COG4249@2|Bacteria,1MXS7@1224|Proteobacteria,43AXK@68525|delta/epsilon subdivisions,2X6BU@28221|Deltaproteobacteria,2MN2G@213118|Desulfobacterales 28221|Deltaproteobacteria S Caspase domain - - - - - - - - - - - - Peptidase_C14 k59_1171837_1 670307.HYPDE_34873 6.33e-20 90.9 COG2010@1|root,COG2993@1|root,COG2010@2|Bacteria,COG2993@2|Bacteria,1MXEY@1224|Proteobacteria,2VFE3@28211|Alphaproteobacteria 28211|Alphaproteobacteria C Cytochrome C oxidase, mono-heme subunit/FixO - - - ko:K00405 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00156 - - ko00000,ko00001,ko00002 3.D.4.3 - - Cytochrom_C,FixO k59_43580_1 596152.DesU5LDRAFT_2640 3.49e-09 57.4 COG1319@1|root,COG1319@2|Bacteria,1MVJS@1224|Proteobacteria,42RX4@68525|delta/epsilon subdivisions,2WNBJ@28221|Deltaproteobacteria,2M9BS@213115|Desulfovibrionales 28221|Deltaproteobacteria C PFAM Molybdopterin dehydrogenase, FAD-binding - - 1.17.1.4 ko:K11178 ko00230,ko01100,ko01120,map00230,map01100,map01120 M00546 R01768,R02103 RC00143 ko00000,ko00001,ko00002,ko01000 - - - CO_deh_flav_C,FAD_binding_5 k59_43580_2 1957.JODX01000006_gene3870 1.42e-10 66.6 COG1529@1|root,COG1529@2|Bacteria,2GIVI@201174|Actinobacteria 201174|Actinobacteria C aldehyde oxidase and xanthine dehydrogenase, a b hammerhead - - 1.17.1.4 ko:K11177 ko00230,ko01100,ko01120,map00230,map01100,map01120 M00546 R01768,R02103 RC00143 ko00000,ko00001,ko00002,ko01000 - - - Ald_Xan_dh_C,Ald_Xan_dh_C2 k59_942844_1 1128421.JAGA01000003_gene3461 9.78e-69 222.0 COG0372@1|root,COG0372@2|Bacteria,2NP9P@2323|unclassified Bacteria 2|Bacteria C Belongs to the citrate synthase family citA GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 2.3.3.1 ko:K01647 ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00740 R00351 RC00004,RC00067 br01601,ko00000,ko00001,ko00002,ko01000 - - - Citrate_synt k59_490595_1 398527.Bphyt_4251 1.53e-34 132.0 COG1060@1|root,COG1060@2|Bacteria,1MX50@1224|Proteobacteria,2VZW4@28216|Betaproteobacteria,1K2DF@119060|Burkholderiaceae 28216|Betaproteobacteria H PFAM Radical SAM - - 2.5.1.77 ko:K11779 ko00680,ko01120,map00680,map01120 M00378 R09396 RC01381,RC03002,RC03007 ko00000,ko00001,ko00002,ko01000 - - - Radical_SAM k59_545872_1 1515746.HR45_02290 8.22e-60 206.0 COG0296@1|root,COG0296@2|Bacteria,1QTVN@1224|Proteobacteria,1RQSK@1236|Gammaproteobacteria,2Q9CX@267890|Shewanellaceae 1236|Gammaproteobacteria G Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position glgB GO:0000271,GO:0003674,GO:0003824,GO:0003844,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0006073,GO:0006091,GO:0006112,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0015980,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033554,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716,GO:0055114,GO:0071704,GO:1901576 2.4.1.18 ko:K00700 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R02110 - ko00000,ko00001,ko00002,ko01000,ko04147 - CBM48,GH13 iAPECO1_1312.APECO1_3025,iECNA114_1301.ECNA114_3542,iECOK1_1307.ECOK1_3857,iECS88_1305.ECS88_3830,iECSF_1327.ECSF_3253,iLF82_1304.LF82_0837,iNRG857_1313.NRG857_17030,iUTI89_1310.UTI89_C3941 Alpha-amylase,Alpha-amylase_C,CBM_48 k59_383671_1 1168065.DOK_13289 1.31e-37 140.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,1J4V4@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains cbrB - - - - - - - - - - - Response_reg,Sigma54_activat k59_608625_1 1178825.ALIH01000002_gene1023 1.27e-56 189.0 COG0534@1|root,COG0534@2|Bacteria,4NEBB@976|Bacteroidetes,1HXAF@117743|Flavobacteriia 976|Bacteroidetes V Mate efflux family protein norM - - ko:K03327 - - - - ko00000,ko02000 2.A.66.1 - - MatE k59_608625_2 946077.W5A_05943 3.48e-31 110.0 2CTUX@1|root,32SU5@2|Bacteria,4NSSU@976|Bacteroidetes,1I51I@117743|Flavobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_154048_1 1249627.D779_0429 3.97e-70 219.0 28KEQ@1|root,2ZA0Y@2|Bacteria,1RBS9@1224|Proteobacteria,1RZ6X@1236|Gammaproteobacteria,1WXTH@135613|Chromatiales 135613|Chromatiales S Short C-terminal domain - - - - - - - - - - - - SHOCT k59_211245_1 1353276.JADR01000005_gene2609 1.05e-32 125.0 COG0545@1|root,COG0545@2|Bacteria,4NJPK@976|Bacteroidetes,1HY2J@117743|Flavobacteriia 976|Bacteroidetes O peptidyl-prolyl - - - - - - - - - - - - FKBP_C k59_490610_1 283699.D172_3909 5.9e-33 124.0 COG1215@1|root,COG1215@2|Bacteria,1MWH9@1224|Proteobacteria,1RPTN@1236|Gammaproteobacteria,2Q11F@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria M COG0463 Glycosyltransferases involved in cell wall biogenesis - - 2.4.1.266 ko:K13693 - - - - ko00000,ko01000,ko01003 - GT81 - - k59_490610_2 1121943.KB899990_gene3588 1.85e-17 83.2 COG3769@1|root,COG3769@2|Bacteria,1NFV5@1224|Proteobacteria,1RR9R@1236|Gammaproteobacteria,1XJXF@135619|Oceanospirillales 135619|Oceanospirillales S Mannosyl-3-phosphoglycerate phosphatase - - 3.1.3.70 ko:K07026 ko00051,map00051 - R05790 RC00017 ko00000,ko00001,ko01000 - - - Hydrolase_3,S6PP k59_942862_1 983545.Glaag_4153 2.04e-42 161.0 COG1629@1|root,COG4206@1|root,COG1629@2|Bacteria,COG4206@2|Bacteria,1QTVF@1224|Proteobacteria,1T40W@1236|Gammaproteobacteria,46D7U@72275|Alteromonadaceae 1236|Gammaproteobacteria P TonB dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_772923_1 95619.PM1_0228995 9.37e-45 157.0 COG0592@1|root,COG0592@2|Bacteria,1MVD9@1224|Proteobacteria,1RMNP@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria dnaN GO:0003674,GO:0003824,GO:0003887,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0022616,GO:0032991,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0042575,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0061695,GO:0071704,GO:0071897,GO:0090304,GO:0140097,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234 2.7.7.7 ko:K02338 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_beta,DNA_pol3_beta_2,DNA_pol3_beta_3 k59_661276_1 1188252.AJYK01000098_gene2832 7.73e-63 204.0 COG0842@1|root,COG0842@2|Bacteria,1MW5R@1224|Proteobacteria,1RPB4@1236|Gammaproteobacteria,1XT9F@135623|Vibrionales 135623|Vibrionales V Transport permease protein - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_3 k59_1338093_1 187303.BN69_2617 7.65e-142 414.0 COG0535@1|root,COG0535@2|Bacteria,1MWDC@1224|Proteobacteria,2TSDD@28211|Alphaproteobacteria,36XQS@31993|Methylocystaceae 28211|Alphaproteobacteria C Dinitrogenase iron-molybdenum cofactor nifB - - ko:K02585 - - - - ko00000 - - - Nitro_FeMo-Co,Radical_SAM k59_1281575_1 199310.c3532 1.36e-161 453.0 COG1385@1|root,COG1385@2|Bacteria,1MXCU@1224|Proteobacteria,1RPBN@1236|Gammaproteobacteria,3XN95@561|Escherichia 1236|Gammaproteobacteria J Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit rsmE GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016436,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070042,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.193 ko:K09761 - - - - ko00000,ko01000,ko03009 - - - Methyltrans_RNA k59_1281575_2 1005994.GTGU_02855 1.05e-05 46.2 COG0189@1|root,COG0189@2|Bacteria,1MVUA@1224|Proteobacteria,1RMU0@1236|Gammaproteobacteria 1236|Gammaproteobacteria H Belongs to the prokaryotic GSH synthase family gshB GO:0000287,GO:0003674,GO:0003824,GO:0004363,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006518,GO:0006575,GO:0006749,GO:0006750,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0019184,GO:0034641,GO:0042398,GO:0043043,GO:0043167,GO:0043169,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0051186,GO:0051188,GO:0071704,GO:1901564,GO:1901566,GO:1901576 6.3.2.3 ko:K01920 ko00270,ko00480,ko01100,map00270,map00480,map01100 M00118 R00497,R10994 RC00096,RC00141 ko00000,ko00001,ko00002,ko01000 - - iECED1_1282.ECED1_3410,iECP_1309.ECP_2941 GSH-S_ATP,GSH-S_N k59_1570669_1 1122137.AQXF01000003_gene1996 5.55e-147 422.0 COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,2TQKE@28211|Alphaproteobacteria 28211|Alphaproteobacteria I acyl-CoA dehydrogenase MA20_27425 - 1.3.8.7 ko:K00249 ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320 M00013,M00036,M00087 R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754 RC00052,RC00068,RC00076,RC00095,RC00148,RC00246 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_1570669_2 1122137.AQXF01000003_gene1997 3.01e-26 105.0 COG1024@1|root,COG1024@2|Bacteria,1MU0B@1224|Proteobacteria,2TQW3@28211|Alphaproteobacteria 28211|Alphaproteobacteria I enoyl-CoA hydratase hibch - 3.1.2.4,4.2.1.17 ko:K01692,ko:K05605 ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01200,map01212 M00013,M00032,M00087 R03026,R03045,R03158,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05064,R05595,R06411,R06412,R06942,R08093 RC00004,RC00014,RC00137,RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 - - - ECH_2 k59_722043_1 118173.KB235914_gene269 5.12e-15 78.6 COG0500@1|root,COG2226@2|Bacteria,1G0IS@1117|Cyanobacteria,1H7VF@1150|Oscillatoriales 1117|Cyanobacteria Q Belongs to the class I-like SAM-binding methyltransferase superfamily. gTMT family - - 2.1.1.95 ko:K05928 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00112 R07236,R07504,R10491,R10492 RC00003,RC01662 ko00000,ko00001,ko00002,ko01000 - - - Methyltransf_11 k59_1788186_1 1415778.JQMM01000001_gene126 1.73e-84 264.0 COG1866@1|root,COG1866@2|Bacteria,1MWXN@1224|Proteobacteria,1RPM0@1236|Gammaproteobacteria,1J53G@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA pckA GO:0003674,GO:0003824,GO:0004611,GO:0004612,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006094,GO:0008150,GO:0008152,GO:0009058,GO:0016051,GO:0016829,GO:0016830,GO:0016831,GO:0019318,GO:0019319,GO:0044238,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046364,GO:0071704,GO:1901576 4.1.1.49 ko:K01610 ko00010,ko00020,ko00620,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00710,map01100,map01110,map01120,map01130,map01200 M00003,M00170 R00341 RC00002,RC02741 ko00000,ko00001,ko00002,ko01000 - - - PEPCK_ATP k59_268945_1 316407.85674359 4.15e-99 305.0 COG0609@1|root,COG0609@2|Bacteria,1MVA3@1224|Proteobacteria,1RN0J@1236|Gammaproteobacteria,3XMUG@561|Escherichia 1236|Gammaproteobacteria P Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily fhuB GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0032991,GO:0043190,GO:0044425,GO:0044459,GO:0044464,GO:0071944,GO:0098533,GO:0098796,GO:0098797,GO:1902494,GO:1902495,GO:1904949,GO:1990351 - ko:K02015 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko02000 3.A.1.14 - iECP_1309.ECP_0163 FecCD k59_1678211_1 1219031.BBJR01000048_gene1744 5.26e-41 139.0 COG3536@1|root,COG3536@2|Bacteria,1MZ5M@1224|Proteobacteria,2VR9K@28216|Betaproteobacteria,4ADW0@80864|Comamonadaceae 28216|Betaproteobacteria S Protein of unknown function (DUF971) - - - - - - - - - - - - DUF971 k59_1678211_2 1209072.ALBT01000026_gene3662 5.91e-118 349.0 COG1220@1|root,COG1220@2|Bacteria,1MVK9@1224|Proteobacteria,1RMYV@1236|Gammaproteobacteria,1FGKV@10|Cellvibrio 1236|Gammaproteobacteria O this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis hslU GO:0000166,GO:0000287,GO:0000502,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009266,GO:0009376,GO:0009408,GO:0009628,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0019904,GO:0022607,GO:0030554,GO:0031597,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0034214,GO:0035639,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043335,GO:0043933,GO:0044085,GO:0044238,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046872,GO:0050896,GO:0051259,GO:0065003,GO:0071704,GO:0071840,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1902494,GO:1904949,GO:1905368,GO:1905369 - ko:K03667 - - - - ko00000,ko03110 - - - AAA_2,ClpB_D2-small k59_772934_1 316407.85676768 3.96e-134 394.0 COG4579@1|root,COG4579@2|Bacteria,1MVRB@1224|Proteobacteria,1RMC2@1236|Gammaproteobacteria,3XM4V@561|Escherichia 1236|Gammaproteobacteria F Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation aceK GO:0000166,GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0004721,GO:0004722,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0006081,GO:0006082,GO:0006091,GO:0006097,GO:0006099,GO:0006101,GO:0006464,GO:0006468,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008772,GO:0009060,GO:0009987,GO:0015980,GO:0016208,GO:0016301,GO:0016310,GO:0016311,GO:0016740,GO:0016772,GO:0016773,GO:0016787,GO:0016788,GO:0016791,GO:0016999,GO:0017076,GO:0017144,GO:0018105,GO:0018193,GO:0018209,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0035639,GO:0036094,GO:0036211,GO:0042578,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044260,GO:0044262,GO:0044267,GO:0044281,GO:0044424,GO:0044464,GO:0045333,GO:0046487,GO:0050790,GO:0055114,GO:0065007,GO:0065009,GO:0070262,GO:0071704,GO:0072350,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564 2.7.11.5 ko:K00906 - - - - ko00000,ko01000 - - - AceK k59_943887_1 1121434.AULY01000006_gene929 2.02e-54 193.0 COG0668@1|root,COG0668@2|Bacteria,1MXD2@1224|Proteobacteria,43C4Y@68525|delta/epsilon subdivisions,2X7FA@28221|Deltaproteobacteria 28221|Deltaproteobacteria M Mechanosensitive ion channel - - - - - - - - - - - - MS_channel k59_1401613_1 330214.NIDE0902 4.2e-66 205.0 COG2010@1|root,COG2010@2|Bacteria 2|Bacteria C Cytochrome c soxD - - ko:K08738 ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416 M00595 R10151 RC03151,RC03152 ko00000,ko00001,ko00002 3.D.4.6 - - Cytochrom_C,Cytochrome_CBB3 k59_1401613_2 330214.NIDE0901 1.12e-24 102.0 COG1271@1|root,COG1271@2|Bacteria 2|Bacteria C aerobic electron transport chain - - 1.10.3.14 ko:K00425,ko:K08738 ko00190,ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00190,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416 M00153,M00595 R10151,R11325 RC00061,RC03151,RC03152 ko00000,ko00001,ko00002,ko01000 3.D.4.3,3.D.4.6 - - Cyt_bd_oxida_I,Cytochrome_CBB3 k59_832498_1 572477.Alvin_0252 1.71e-48 171.0 COG0438@1|root,COG0561@1|root,COG0438@2|Bacteria,COG0561@2|Bacteria,1MWVX@1224|Proteobacteria,1RSR5@1236|Gammaproteobacteria,1WWRD@135613|Chromatiales 135613|Chromatiales M HAD-superfamily hydrolase, subfamily IIB - - 2.4.1.14 ko:K00696 ko00500,ko01100,map00500,map01100 - R00766 RC00005,RC00028,RC02748 ko00000,ko00001,ko01000 - GT4 - Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1,S6PP,Sucrose_synth k59_832498_2 1123253.AUBD01000005_gene171 1.03e-44 155.0 COG3588@1|root,COG3588@2|Bacteria,1MVFK@1224|Proteobacteria,1RQ57@1236|Gammaproteobacteria,1X34A@135614|Xanthomonadales 135614|Xanthomonadales G Belongs to the class I fructose-bisphosphate aldolase family - - 4.1.2.13 ko:K01623 ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00003,M00165,M00167 R01068,R01070,R01829,R02568 RC00438,RC00439,RC00603,RC00604 ko00000,ko00001,ko00002,ko01000,ko03036,ko04131,ko04147 - - - Glycolytic k59_44425_1 391612.CY0110_25486 1.21e-22 102.0 COG0642@1|root,COG2202@1|root,COG3899@1|root,COG5002@1|root,COG2202@2|Bacteria,COG2205@2|Bacteria,COG3899@2|Bacteria,COG5002@2|Bacteria,1GD97@1117|Cyanobacteria,3KHHW@43988|Cyanothece 1117|Cyanobacteria T Serine Threonine protein kinase - - - - - - - - - - - - AAA_16,GAF,HATPase_c,HisKA,PAS_9,Response_reg k59_773693_1 1007103.AFHW01000076_gene5647 7.93e-21 97.1 COG0454@1|root,COG0456@2|Bacteria,1TQQA@1239|Firmicutes,4HBXN@91061|Bacilli,26RQ4@186822|Paenibacillaceae 91061|Bacilli K Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_1,Acetyltransf_10 k59_327904_1 1429916.X566_00775 3.5e-35 128.0 28Z3J@1|root,2ZKW1@2|Bacteria,1P95B@1224|Proteobacteria,2UYJR@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_384588_1 349102.Rsph17025_0709 5.86e-53 180.0 COG0646@1|root,COG0646@2|Bacteria,1NPFY@1224|Proteobacteria,2UJRS@28211|Alphaproteobacteria,1FBF2@1060|Rhodobacter 28211|Alphaproteobacteria H PFAM homocysteine S-methyltransferase yitJ - 2.1.1.13,2.1.1.5 ko:K00544,ko:K00548 ko00260,ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00260,map00270,map00450,map00670,map01100,map01110,map01230 M00017 R00946,R02821,R09365 RC00035,RC00113,RC00496,RC01241 ko00000,ko00001,ko00002,ko01000 - - - S-methyl_trans k59_943908_1 1229909.NSED_04990 2.55e-81 254.0 COG1199@1|root,arCOG00770@2157|Archaea,41T2V@651137|Thaumarchaeota 651137|Thaumarchaeota K HELICc2 - - - - - - - - - - - - Helicase_C_2 k59_943908_2 929562.Emtol_2658 5.79e-10 63.2 COG2204@1|root,COG2204@2|Bacteria,4NE89@976|Bacteroidetes,47JKI@768503|Cytophagia 976|Bacteroidetes T CheY-like receiver AAA-type ATPase and DNA-binding domains ntrX - - - - - - - - - - - HTH_8,Response_reg,Sigma54_activat k59_1514104_1 565045.NOR51B_1765 3.48e-08 54.7 COG0526@1|root,COG0526@2|Bacteria,1R3WA@1224|Proteobacteria 1224|Proteobacteria CO methylamine dehydrogenase accessory protein MauD - - - - - - - - - - - - AhpC-TSA,Redoxin k59_1514104_2 1219045.BV98_002169 1.8e-65 205.0 28V8Y@1|root,2ZHBX@2|Bacteria,1RD5G@1224|Proteobacteria,2U7RU@28211|Alphaproteobacteria,2K4YJ@204457|Sphingomonadales 204457|Sphingomonadales C PFAM methylamine dehydrogenase light chain, C terminal domain protein - - 1.4.9.1 ko:K15228 ko00680,ko01120,map00680,map01120 - R00606 RC00189 ko00000,ko00001,ko01000 - - - Me-amine-dh_L k59_1679154_1 398525.KB900701_gene3719 1.32e-29 120.0 COG0587@1|root,COG0587@2|Bacteria,1MUE4@1224|Proteobacteria,2TRUB@28211|Alphaproteobacteria,3JUU5@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria L DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase dnaE2 GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0050896,GO:0051716,GO:0071496 2.7.7.7 ko:K02337,ko:K14162 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon k59_1228589_1 985054.JQEZ01000005_gene287 1.09e-43 169.0 COG0658@1|root,COG0658@2|Bacteria,1MUKF@1224|Proteobacteria,2TRD5@28211|Alphaproteobacteria,4NBUB@97050|Ruegeria 28211|Alphaproteobacteria S Domain of unknown function (DUF4131) - - - ko:K02238 - M00429 - - ko00000,ko00002,ko02044 3.A.11.1,3.A.11.2 - - Competence,DUF4131 k59_212089_1 1452718.JBOY01000057_gene1815 7.01e-24 104.0 COG3547@1|root,COG3547@2|Bacteria,1MXKJ@1224|Proteobacteria,1RSCP@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Transposase - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_773704_1 267377.MMP0833 4.31e-18 85.9 COG0523@1|root,arCOG01232@2157|Archaea,2Y8HY@28890|Euryarchaeota,23RHT@183939|Methanococci 183939|Methanococci S Cobalamin synthesis protein cobW C-terminal domain - - - - - - - - - - - - CobW_C,cobW k59_832521_1 1459636.NTE_00763 1.05e-88 273.0 COG0596@1|root,arCOG07416@1|root,arCOG01648@2157|Archaea,arCOG07416@2157|Archaea,41SFU@651137|Thaumarchaeota 2157|Archaea S Alpha beta hydrolase - - - - - - - - - - - - Abhydrolase_1,Abhydrolase_4,Abhydrolase_6 k59_1346243_2 1123279.ATUS01000004_gene2915 1.13e-29 110.0 COG3216@1|root,COG3216@2|Bacteria,1RGV6@1224|Proteobacteria,1S682@1236|Gammaproteobacteria,1J6CA@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S protein conserved in bacteria TLL0138 - - ko:K09928 - - - - ko00000 - - - DUF2062 k59_219170_1 1303692.SFUL_2890 8.08e-59 204.0 COG1073@1|root,COG1073@2|Bacteria,2GMK3@201174|Actinobacteria 201174|Actinobacteria S alpha beta - - - ko:K06889 - - - - ko00000 - - - Abhydrolase_1,Abhydrolase_4,Hydrolase_4,Peptidase_S9 k59_219170_2 450851.PHZ_c0425 4.06e-60 195.0 COG0119@1|root,COG0119@2|Bacteria,1MUMX@1224|Proteobacteria,2TT1R@28211|Alphaproteobacteria,2KFEX@204458|Caulobacterales 204458|Caulobacterales E Hydroxymethylglutaryl-CoA lyase - - 4.1.3.4 ko:K01640 ko00072,ko00280,ko00281,ko00650,ko01100,ko04146,map00072,map00280,map00281,map00650,map01100,map04146 M00036,M00088 R01360,R08090 RC00502,RC00503,RC01118,RC01946 ko00000,ko00001,ko00002,ko01000 - - - HMGL-like k59_51587_1 1121918.ARWE01000001_gene2495 1.47e-23 93.2 2BIZB@1|root,32D7T@2|Bacteria,1Q9TV@1224|Proteobacteria,431GP@68525|delta/epsilon subdivisions,2WWKI@28221|Deltaproteobacteria,43VCZ@69541|Desulfuromonadales 28221|Deltaproteobacteria S Putative prokaryotic signal transducing protein - - - - - - - - - - - - DUF2007 k59_51587_2 519989.ECTPHS_02411 6.89e-32 119.0 COG1432@1|root,COG1432@2|Bacteria,1MZIU@1224|Proteobacteria 1224|Proteobacteria S NYN domain - - - - - - - - - - - - NYN k59_1459752_1 1144305.PMI02_05307 6.47e-73 244.0 COG0457@1|root,COG5010@1|root,COG0457@2|Bacteria,COG5010@2|Bacteria,1MVB8@1224|Proteobacteria,2U28P@28211|Alphaproteobacteria,2K2RP@204457|Sphingomonadales 204457|Sphingomonadales U PFAM Cellulose synthase operon - - - ko:K20543 - - - - ko00000,ko02000 1.B.55.3 - - BCSC_C,TPR_16,TPR_19 k59_617050_1 1123355.JHYO01000008_gene2616 2.58e-20 86.7 COG3023@1|root,COG3023@2|Bacteria,1RDHU@1224|Proteobacteria,2TSW3@28211|Alphaproteobacteria,36Y15@31993|Methylocystaceae 28211|Alphaproteobacteria V Ami_2 ampD - 2.5.1.3,3.5.1.28 ko:K00788,ko:K01447,ko:K03806,ko:K11066 ko00730,ko01100,map00730,map01100 M00127 R03223,R04112,R10712 RC00064,RC00141,RC00224,RC03255,RC03397 ko00000,ko00001,ko00002,ko01000,ko01011 - - - Amidase_2,PG_binding_1 k59_617050_2 1122137.AQXF01000003_gene2258 1.33e-36 132.0 COG0697@1|root,COG0697@2|Bacteria,1MVKG@1224|Proteobacteria,2U30N@28211|Alphaproteobacteria 28211|Alphaproteobacteria EG COG0697 Permeases of the drug metabolite transporter (DMT) superfamily - - - ko:K15268 - - - - ko00000,ko02000 2.A.7.3.2 - - EamA k59_839974_1 1122137.AQXF01000001_gene3104 1e-184 521.0 COG0137@1|root,COG0137@2|Bacteria,1MV0Y@1224|Proteobacteria,2TTGS@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Belongs to the argininosuccinate synthase family. Type 1 subfamily argG GO:0000050,GO:0000053,GO:0003674,GO:0003824,GO:0004055,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006575,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0019627,GO:0019752,GO:0034641,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:0072350,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 6.3.4.5 ko:K01940 ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418 M00029,M00844,M00845 R01954 RC00380,RC00629 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Arginosuc_synth k59_839974_2 1122137.AQXF01000001_gene3103 2.52e-22 93.6 COG0679@1|root,COG0679@2|Bacteria,1MY23@1224|Proteobacteria,2TR4M@28211|Alphaproteobacteria 28211|Alphaproteobacteria S auxin efflux carrier - - - ko:K07088 - - - - ko00000 - - - Mem_trans k59_1459773_1 702113.PP1Y_AT18880 2.84e-107 334.0 COG0525@1|root,COG0525@2|Bacteria,1MV7B@1224|Proteobacteria,2TS9E@28211|Alphaproteobacteria,2K0N3@204457|Sphingomonadales 204457|Sphingomonadales J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner valS - 6.1.1.9 ko:K01873 ko00970,map00970 M00359,M00360 R03665 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1 k59_277251_1 324925.Ppha_0864 3.69e-18 89.7 COG0768@1|root,COG0768@2|Bacteria,1FD7D@1090|Chlorobi 1090|Chlorobi M PFAM penicillin-binding protein transpeptidase - - 3.4.16.4 ko:K05515 ko00550,ko01501,map00550,map01501 - - - ko00000,ko00001,ko01000,ko01011 - - - PBP_dimer,Transpeptidase k59_498166_1 1273538.G159_19495 1.96e-28 107.0 COG0745@1|root,COG0745@2|Bacteria,1VAYR@1239|Firmicutes,4HKT2@91061|Bacilli,26FRF@186818|Planococcaceae 91061|Bacilli T cheY-homologous receiver domain - - - - - - - - - - - - Response_reg k59_1408914_1 1453501.JELR01000002_gene784 3.13e-92 286.0 COG0760@1|root,COG0760@2|Bacteria,1MVB3@1224|Proteobacteria,1RMWU@1236|Gammaproteobacteria,4658B@72275|Alteromonadaceae 1236|Gammaproteobacteria M Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation surA GO:0000413,GO:0003674,GO:0003755,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006457,GO:0006458,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0016853,GO:0016859,GO:0018193,GO:0018208,GO:0019538,GO:0022607,GO:0030288,GO:0030313,GO:0031647,GO:0031975,GO:0033218,GO:0036211,GO:0042277,GO:0042597,GO:0043163,GO:0043165,GO:0043170,GO:0043412,GO:0044085,GO:0044091,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0044764,GO:0045229,GO:0050821,GO:0051082,GO:0051084,GO:0051085,GO:0051704,GO:0060274,GO:0061024,GO:0061077,GO:0065007,GO:0065008,GO:0071704,GO:0071709,GO:0071840,GO:0140096,GO:1901564 5.2.1.8 ko:K03771 - - - - ko00000,ko01000,ko03110 - - - Rotamase,Rotamase_3,SurA_N k59_1686806_1 998674.ATTE01000001_gene2777 2.98e-41 154.0 COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,1RN2C@1236|Gammaproteobacteria,45ZPW@72273|Thiotrichales 72273|Thiotrichales P heavy metal translocating P-type ATPase - - 3.6.3.4 ko:K01533 - - R00086 RC00002 ko00000,ko01000 3.A.3.5 - - ATPase-cat_bd,E1-E2_ATPase,HMA,Hydrolase k59_1686806_2 322710.Avin_19940 5.43e-11 58.5 COG3197@1|root,COG3197@2|Bacteria,1NG90@1224|Proteobacteria,1SGQG@1236|Gammaproteobacteria 1236|Gammaproteobacteria P Cytochrome oxidase maturation protein ccoS - - - - - - - - - - - FixS k59_334857_1 436308.Nmar_1621 2.82e-112 329.0 COG2301@1|root,arCOG00760@2157|Archaea,41S6F@651137|Thaumarchaeota 651137|Thaumarchaeota G HpcH/HpaI aldolase/citrate lyase family - - 4.1.3.34 ko:K01644 ko02020,map02020 - R00362 RC00067,RC01118 ko00000,ko00001,ko01000 - - - HpcH_HpaI k59_839981_1 1121374.KB891576_gene548 1.5e-68 236.0 COG1629@1|root,COG4771@2|Bacteria,1QWIP@1224|Proteobacteria,1RZ72@1236|Gammaproteobacteria 1236|Gammaproteobacteria P Outer membrane protein beta-barrel family - - - ko:K16089 - - - - ko00000,ko02000 1.B.14.1,1.B.14.10 - - OMP_b-brl_3,Plug,TonB_dep_Rec k59_951027_1 1137281.D778_02000 1.57e-93 294.0 COG3590@1|root,COG3590@2|Bacteria,4NEYB@976|Bacteroidetes,1HX3E@117743|Flavobacteriia 976|Bacteroidetes O peptidase family M13 pepO - 3.4.24.71 ko:K01415,ko:K07386 - - - - ko00000,ko01000,ko01002,ko04147 - - - Peptidase_M13,Peptidase_M13_N k59_780446_1 1198452.Jab_2c01520 9.68e-79 256.0 COG2114@1|root,COG2203@1|root,COG2114@2|Bacteria,COG2203@2|Bacteria,1MV1V@1224|Proteobacteria,2VJ72@28216|Betaproteobacteria,4736W@75682|Oxalobacteraceae 28216|Betaproteobacteria T Adenylyl- / guanylyl cyclase, catalytic domain - - 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 - - - Guanylate_cyc,HAMP k59_51606_1 504487.JCM19302_1403 6.34e-126 364.0 COG0331@1|root,COG0331@2|Bacteria,4NE1D@976|Bacteroidetes,1HWU7@117743|Flavobacteriia 976|Bacteroidetes I malonyl coa-acyl carrier protein transacylase fabD - 2.3.1.39 ko:K00645 ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212 M00082 R01626,R11671 RC00004,RC00039,RC02727 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Acyl_transf_1 k59_162096_1 879243.Poras_0046 2.07e-05 53.1 COG0612@1|root,COG0612@2|Bacteria,4NFY0@976|Bacteroidetes,2FMCE@200643|Bacteroidia,22WW4@171551|Porphyromonadaceae 976|Bacteroidetes S Belongs to the peptidase M16 family - - - ko:K07263 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M16,Peptidase_M16_C k59_219207_1 1122137.AQXF01000005_gene1092 5.27e-148 451.0 COG1196@1|root,COG1196@2|Bacteria,1MUAQ@1224|Proteobacteria,2TRQG@28211|Alphaproteobacteria 28211|Alphaproteobacteria D Required for chromosome condensation and partitioning smc - - ko:K03529 - - - - ko00000,ko03036 - - - SMC_N k59_219207_2 1443111.JASG01000004_gene3506 1.6e-35 132.0 COG1651@1|root,COG1651@2|Bacteria,1RFF4@1224|Proteobacteria,2U5BN@28211|Alphaproteobacteria,3ZVHG@60136|Sulfitobacter 28211|Alphaproteobacteria O Thioredoxin MA20_42440 - - - - - - - - - - - Thioredoxin_4 k59_219207_3 412597.AEPN01000050_gene3772 7.84e-24 101.0 COG1651@1|root,COG1651@2|Bacteria,1RFF4@1224|Proteobacteria,2U5BN@28211|Alphaproteobacteria,2PUWE@265|Paracoccus 28211|Alphaproteobacteria O Thioredoxin MA20_42440 - - - - - - - - - - - Thioredoxin_4 k59_219207_4 1122137.AQXF01000005_gene1095 3.29e-05 45.4 COG5389@1|root,COG5389@2|Bacteria 2|Bacteria S Protein of unknown function (DUF721) MA20_42435 - - - - - - - - - - - DUF721 k59_1796148_1 1123251.ATWM01000003_gene1261 2.43e-62 198.0 COG1272@1|root,COG1272@2|Bacteria,2GJGQ@201174|Actinobacteria,4FEMN@85021|Intrasporangiaceae 201174|Actinobacteria S DNA-binding protein hlyIII - - ko:K11068 - - - - ko00000,ko02042 - - - HlyIII k59_669199_1 1101191.KI912577_gene3119 1.59e-39 147.0 COG5323@1|root,COG5323@2|Bacteria,1MW8S@1224|Proteobacteria,2TREI@28211|Alphaproteobacteria,1JUBX@119045|Methylobacteriaceae 28211|Alphaproteobacteria S Terminase RNaseH-like domain - - - - - - - - - - - - Terminase_3,Terminase_6,Terminase_6C k59_1459825_1 1274524.BSONL12_02042 0.000277 47.4 COG0739@1|root,COG1388@1|root,COG0739@2|Bacteria,COG1388@2|Bacteria,1V3ZU@1239|Firmicutes,4I27X@91061|Bacilli,1ZGNS@1386|Bacillus 91061|Bacilli M COG0739 Membrane proteins related to metalloendopeptidases - - - - - - - - - - - - LysM,Peptidase_M23 k59_900276_1 1089455.MOPEL_096_01160 1.1e-83 275.0 COG0178@1|root,COG0178@2|Bacteria,2GJUV@201174|Actinobacteria,4F6BT@85018|Dermatophilaceae 201174|Actinobacteria L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate uvrA GO:0000018,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006950,GO:0006974,GO:0008150,GO:0009892,GO:0009987,GO:0010605,GO:0016020,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031324,GO:0033554,GO:0044424,GO:0044444,GO:0044464,GO:0045910,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051053,GO:0051171,GO:0051172,GO:0051716,GO:0060255,GO:0060542,GO:0060543,GO:0065007,GO:0071944,GO:0080090 - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - ABC_tran k59_1120776_1 96561.Dole_2848 4.06e-46 175.0 COG4191@1|root,COG4191@2|Bacteria,1QU7R@1224|Proteobacteria,43BS1@68525|delta/epsilon subdivisions,2X72V@28221|Deltaproteobacteria,2MPJD@213118|Desulfobacterales 28221|Deltaproteobacteria T PFAM ATP-binding region ATPase domain protein - - 2.7.13.3 ko:K02668 ko02020,map02020 M00501 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 - - - HATPase_c,HisKA k59_780472_1 627192.SLG_18950 2.14e-41 158.0 COG1629@1|root,COG4771@2|Bacteria,1MWKN@1224|Proteobacteria,2U3VD@28211|Alphaproteobacteria,2K0FN@204457|Sphingomonadales 204457|Sphingomonadales P Protein involved in receptor activity and transport - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_162110_1 45157.CMQ255CT 1.72e-57 201.0 COG0458@1|root,KOG0370@2759|Eukaryota 2759|Eukaryota EF carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity URA2 GO:0000050,GO:0003674,GO:0003824,GO:0003922,GO:0004070,GO:0004087,GO:0004088,GO:0004151,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0006082,GO:0006139,GO:0006142,GO:0006206,GO:0006207,GO:0006520,GO:0006525,GO:0006526,GO:0006541,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009112,GO:0009892,GO:0009987,GO:0016020,GO:0016021,GO:0016053,GO:0016740,GO:0016741,GO:0016743,GO:0016787,GO:0016810,GO:0016812,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019219,GO:0019222,GO:0019627,GO:0019752,GO:0019856,GO:0031224,GO:0031323,GO:0031324,GO:0034641,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044425,GO:0044444,GO:0044464,GO:0045934,GO:0045984,GO:0046112,GO:0046394,GO:0046483,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0055086,GO:0062012,GO:0062014,GO:0065007,GO:0071704,GO:0071941,GO:0072527,GO:0072528,GO:0080090,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.1.3.2,3.5.2.3,6.3.5.5 ko:K01954,ko:K01955,ko:K11540,ko:K11541 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R01397,R01993,R10948,R10949 RC00002,RC00010,RC00043,RC00064,RC00632,RC02750,RC02798,RC02850,RC03314 ko00000,ko00001,ko00002,ko01000,ko01002 - - - CPSase_L_D2,CPSase_L_D3,CPSase_sm_chain,GATase,MGS,OTCace,OTCace_N k59_1631575_2 1101195.Meth11DRAFT_1780 4.21e-33 125.0 COG0340@1|root,COG1654@1|root,COG0340@2|Bacteria,COG1654@2|Bacteria,1MWCC@1224|Proteobacteria,2VNXD@28216|Betaproteobacteria,2KMHI@206350|Nitrosomonadales 206350|Nitrosomonadales HK Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a repressor birA - 6.3.4.15 ko:K03524 ko00780,ko01100,map00780,map01100 - R01074,R05145 RC00043,RC00070,RC00096,RC02896 ko00000,ko00001,ko01000,ko03000 - - - BPL_C,BPL_LplA_LipB,HTH_11 k59_1290185_2 1122137.AQXF01000005_gene1078 1.29e-84 257.0 COG0625@1|root,COG0625@2|Bacteria,1NFA1@1224|Proteobacteria 1224|Proteobacteria O Glutathione S-transferase, C-terminal domain - - - - - - - - - - - - GST_C_2,GST_N_3 k59_1290185_3 1122137.AQXF01000005_gene1077 2e-44 147.0 COG3791@1|root,COG3791@2|Bacteria,1N6S5@1224|Proteobacteria,2UG0P@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Glutathione-dependent formaldehyde-activating - - - - - - - - - - - - GFA k59_1632610_1 391603.FBALC1_01447 6.76e-08 51.6 COG0537@1|root,COG0537@2|Bacteria,4NQ4X@976|Bacteroidetes,1I1YY@117743|Flavobacteriia 976|Bacteroidetes FG HIT family hinT - - ko:K02503 - - - - ko00000,ko04147 - - - HIT k59_1632610_2 1197477.IA57_06755 7.4e-42 140.0 2E6VJ@1|root,331F5@2|Bacteria,4NUPN@976|Bacteroidetes,1I5JT@117743|Flavobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_1632610_3 1137281.D778_01552 4.42e-65 209.0 COG5000@1|root,COG5000@2|Bacteria,4PKJN@976|Bacteroidetes,1IJB1@117743|Flavobacteriia 976|Bacteroidetes T Signal Transduction Histidine Kinase - - - - - - - - - - - - HATPase_c,HisKA k59_901287_1 1197719.A464_3592 6.2e-56 186.0 COG2610@1|root,COG2610@2|Bacteria,1MUFG@1224|Proteobacteria,1RNGE@1236|Gammaproteobacteria,3ZJYT@590|Salmonella 1236|Gammaproteobacteria EG Na+/H+ antiporter family gntT GO:0003674,GO:0005215,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0008028,GO:0008150,GO:0008509,GO:0008514,GO:0008643,GO:0015075,GO:0015128,GO:0015144,GO:0015318,GO:0015711,GO:0015718,GO:0015849,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034219,GO:0034220,GO:0035429,GO:0042873,GO:0042879,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0046943,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0098656,GO:1903825,GO:1905039 - ko:K06155,ko:K06157 - - - - ko00000,ko02000 2.A.8.1.2,2.A.8.1.4 - iSSON_1240.SSON_3547 GntP_permease k59_1744769_1 436308.Nmar_1794 3.86e-175 521.0 COG1933@1|root,arCOG04447@2157|Archaea,41SYW@651137|Thaumarchaeota 651137|Thaumarchaeota L Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase polC - 2.7.7.7 ko:K02322 ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030 M00264 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032 - - - PolC_DP2 k59_336011_1 436308.Nmar_1604 5.53e-105 311.0 COG0704@1|root,arCOG00318@2157|Archaea,41SC5@651137|Thaumarchaeota 651137|Thaumarchaeota K Phosphate uptake regulator - - - - - - - - - - - - MazE_antitoxin,PhoU k59_731362_1 1183438.GKIL_0152 2.49e-18 87.0 COG0827@1|root,COG0827@2|Bacteria,1G1QA@1117|Cyanobacteria 1117|Cyanobacteria L Eco57I restriction endonuclease - - 2.1.1.72 ko:K07317 - - - - ko00000,ko01000,ko02048 - - - Eco57I,N6_Mtase k59_1632617_1 1122137.AQXF01000002_gene188 4.12e-23 97.4 COG0671@1|root,COG0671@2|Bacteria,1RDK3@1224|Proteobacteria,2U7BJ@28211|Alphaproteobacteria 28211|Alphaproteobacteria I PFAM phosphoesterase, PA-phosphatase related - - 3.6.1.27 ko:K19302 ko00550,map00550 - R05627 RC00002 ko00000,ko00001,ko01000,ko01011 - - - PAP2 k59_952144_1 883078.HMPREF9695_00769 1.97e-135 409.0 COG1060@1|root,COG1060@2|Bacteria,1MX50@1224|Proteobacteria,2TRX7@28211|Alphaproteobacteria,3JW8K@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria H Radical SAM superfamily fbiC - 2.5.1.77 ko:K11779 ko00680,ko01120,map00680,map01120 M00378 R09396 RC01381,RC03002,RC03007 ko00000,ko00001,ko00002,ko01000 - - - Radical_SAM k59_618197_1 314285.KT71_12715 7.07e-59 191.0 COG0363@1|root,COG0363@2|Bacteria,1R5K6@1224|Proteobacteria,1S11C@1236|Gammaproteobacteria,1J6AG@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria G Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase pgl - 3.1.1.31 ko:K01057 ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200 M00004,M00006,M00008 R02035 RC00537 ko00000,ko00001,ko00002,ko01000 - - - Glucosamine_iso k59_1687843_1 519989.ECTPHS_01884 2.79e-45 156.0 COG0812@1|root,COG0812@2|Bacteria,1MXDH@1224|Proteobacteria,1RNXK@1236|Gammaproteobacteria,1WW8T@135613|Chromatiales 135613|Chromatiales M Cell wall formation murB - 1.3.1.98 ko:K00075 ko00520,ko00550,ko01100,map00520,map00550,map01100 - R03191,R03192 RC02639 ko00000,ko00001,ko01000,ko01011 - - - FAD_binding_4,MurB_C k59_1687843_2 105559.Nwat_0228 5.01e-06 49.3 COG0773@1|root,COG0773@2|Bacteria,1MV68@1224|Proteobacteria,1RN88@1236|Gammaproteobacteria,1WW6B@135613|Chromatiales 135613|Chromatiales M Belongs to the MurCDEF family murC - 6.3.2.8 ko:K01924 ko00471,ko00550,ko01100,map00471,map00550,map01100 - R03193 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_1347340_1 199310.c1722 5.34e-144 407.0 COG3047@1|root,COG3047@2|Bacteria,1NUZJ@1224|Proteobacteria,1RRRC@1236|Gammaproteobacteria,3XNF5@561|Escherichia 1236|Gammaproteobacteria M Outer membrane protein W ompW GO:0005575,GO:0005623,GO:0009279,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0044462,GO:0044464,GO:0071944 - ko:K07275 - - - - ko00000 - - - OmpW k59_1347340_2 316407.1742044 1.13e-149 424.0 28JC8@1|root,2Z96Y@2|Bacteria,1PYD0@1224|Proteobacteria,1RQC3@1236|Gammaproteobacteria,3XM32@561|Escherichia 1236|Gammaproteobacteria S Uncharacterised protein family (UPF0259) yciC GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - - - - - - - - - - UPF0259 k59_336030_1 436308.Nmar_0273 2.07e-63 207.0 COG0439@1|root,arCOG01590@2157|Archaea,41SXC@651137|Thaumarchaeota 651137|Thaumarchaeota I Carbamoyl-phosphate synthase L chain - - 6.4.1.2,6.4.1.3 ko:K18603 ko00720,ko01120,map00720,map01120 - R00742,R01859 RC00040,RC00097,RC00367,RC00609 ko00000,ko00001,ko01000 - - - Biotin_carb_C,Biotin_carb_N,CPSase_L_D2 k59_336030_2 1229909.NSED_01260 0.0 960.0 COG4799@1|root,arCOG02705@2157|Archaea,41SEH@651137|Thaumarchaeota 651137|Thaumarchaeota I Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) - - 2.1.3.15,6.4.1.2,6.4.1.3 ko:K18604 ko00720,ko01120,map00720,map01120 - R00742,R01859 RC00040,RC00097,RC00367,RC00609 ko00000,ko00001,ko01000 - - - Carboxyl_trans k59_336030_3 1229909.NSED_01235 9.73e-136 391.0 COG1018@1|root,arCOG02200@2157|Archaea,41S72@651137|Thaumarchaeota 651137|Thaumarchaeota C oxidoreductase FAD NAD(P)-binding - - 1.18.1.2,1.19.1.1 ko:K00528 - - R10159 - ko00000,ko01000 - - - FAD_binding_6,NAD_binding_1 k59_336030_4 1229909.NSED_01230 8.95e-25 93.6 COG5466@1|root,arCOG05278@2157|Archaea,41T8X@651137|Thaumarchaeota 651137|Thaumarchaeota S Protein of unknown function (DUF1059) - - - - - - - - - - - - DUF1059 k59_1744785_1 566466.NOR53_3482 6.69e-22 95.5 COG0189@1|root,COG4067@1|root,COG0189@2|Bacteria,COG4067@2|Bacteria,1MX62@1224|Proteobacteria,1RM8B@1236|Gammaproteobacteria,1J862@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria HJO Putative ATP-dependant zinc protease rimK - - ko:K05844 - - - - ko00000,ko01000,ko03009 - - - RimK,Zn_protease k59_1744785_2 247633.GP2143_06883 1.06e-78 242.0 COG0189@1|root,COG0189@2|Bacteria,1MX62@1224|Proteobacteria,1RM8B@1236|Gammaproteobacteria,1J55C@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria F COG0189 Glutathione synthase Ribosomal protein S6 modification enzyme (glutaminyl transferase) rimK GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0016874,GO:0016879,GO:0016881,GO:0018169,GO:0018410,GO:0019538,GO:0031668,GO:0033554,GO:0036211,GO:0042802,GO:0043170,GO:0043412,GO:0043687,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0050896,GO:0051716,GO:0070739,GO:0071496,GO:0071704,GO:0140096,GO:1901564 - ko:K05844 - - - - ko00000,ko01000,ko03009 - - - RimK k59_443992_1 1121090.KB894691_gene2572 1.06e-10 63.5 COG0665@1|root,COG0665@2|Bacteria,1TQTF@1239|Firmicutes,4HA0F@91061|Bacilli,1ZBU6@1386|Bacillus 91061|Bacilli E COG0665 Glycine D-amino acid oxidases (deaminating) yurR GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0016491,GO:0044424,GO:0044464,GO:0055114 1.4.5.1 ko:K00285 ko00360,map00360 - R01374,R09493 RC00006,RC00025 ko00000,ko00001,ko01000 - - - DAO k59_443992_2 1121085.AUCI01000029_gene2476 2.12e-08 60.8 COG0498@1|root,COG0498@2|Bacteria,1TP25@1239|Firmicutes,4HCEB@91061|Bacilli,1ZRBJ@1386|Bacillus 91061|Bacilli E Pyridoxal-phosphate dependent enzyme thrC_1 - 4.2.3.1 ko:K01733 ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230 M00018 R01466,R05086 RC00017,RC00526 ko00000,ko00001,ko00002,ko01000 - - - PALP k59_1007665_1 671143.DAMO_0969 9.65e-59 200.0 COG0058@1|root,COG3350@1|root,COG0058@2|Bacteria,COG3350@2|Bacteria,2NNZS@2323|unclassified Bacteria 2|Bacteria G Carbohydrate phosphorylase - - 2.4.1.1 ko:K00688 ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931 - R02111 - ko00000,ko00001,ko01000 - GT35 - Phosphorylase,YHS k59_52718_1 981369.JQMJ01000004_gene4366 3.98e-51 184.0 COG4581@1|root,COG4581@2|Bacteria,2GJEX@201174|Actinobacteria,2NFZN@228398|Streptacidiphilus 201174|Actinobacteria L DSHCT helY GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009056,GO:0009057,GO:0009987,GO:0016020,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019439,GO:0030312,GO:0034641,GO:0034655,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0070035,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:1901360,GO:1901361,GO:1901575 - ko:K03727 - - - - ko00000,ko01000 - - - DEAD,DSHCT,Helicase_C,rRNA_proc-arch k59_1068956_1 344747.PM8797T_31048 5.13e-33 133.0 COG0642@1|root,COG5012@1|root,COG2205@2|Bacteria,COG5012@2|Bacteria,2IX8Z@203682|Planctomycetes 203682|Planctomycetes T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - GAF_2,HATPase_c,HisKA,PAS_4,PAS_9,Response_reg k59_901320_2 1229909.NSED_04955 3.15e-68 209.0 COG0537@1|root,arCOG00419@2157|Archaea,41SNV@651137|Thaumarchaeota 651137|Thaumarchaeota F HIT domain - - - ko:K02503 - - - - ko00000,ko04147 - - - HIT k59_1410071_1 509635.N824_13325 5.6e-50 168.0 COG3751@1|root,COG3751@2|Bacteria,4NI8F@976|Bacteroidetes,1IYHN@117747|Sphingobacteriia 976|Bacteroidetes O Prolyl 4-hydroxylase alpha subunit homologues. - - - - - - - - - - - - 2OG-FeII_Oxy_3 k59_1410071_2 1211115.ALIQ01000237_gene2497 1.24e-12 72.8 COG3307@1|root,COG3307@2|Bacteria,1N225@1224|Proteobacteria,2U0RV@28211|Alphaproteobacteria,3NCPK@45404|Beijerinckiaceae 28211|Alphaproteobacteria M O-Antigen ligase - - - - - - - - - - - - Wzy_C k59_1522309_1 187272.Mlg_2632 1.05e-83 272.0 COG0550@1|root,COG1754@1|root,COG0550@2|Bacteria,COG1754@2|Bacteria,1MUFZ@1224|Proteobacteria,1RNZ2@1236|Gammaproteobacteria,1WWWP@135613|Chromatiales 135613|Chromatiales L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone topA - 5.99.1.2 ko:K03168 - - - - ko00000,ko01000,ko03032,ko03400 - - - Topo_Zn_Ribbon,Topoisom_bac,Toprim,Toprim_C_rpt,zf-C4_Topoisom k59_841120_1 1218075.BAYA01000001_gene373 3.78e-51 194.0 COG3321@1|root,COG3321@2|Bacteria,1R89Z@1224|Proteobacteria,2VP69@28216|Betaproteobacteria,1KG3G@119060|Burkholderiaceae 28216|Betaproteobacteria Q Beta-ketoacyl synthase wcbR - - - - - - - - - - - ADH_zinc_N,Acyl_transf_1,KAsynt_C_assoc,KR,Ketoacyl-synt_C,Methyltransf_23,PP-binding,PS-DH,ketoacyl-synt k59_1180683_1 666685.R2APBS1_2795 1.43e-72 237.0 COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,1RN5K@1236|Gammaproteobacteria,1X4G6@135614|Xanthomonadales 135614|Xanthomonadales MU Outer membrane efflux protein - - - - - - - - - - - - OEP k59_1180683_2 1169143.KB911039_gene4467 4.47e-23 96.7 COG0583@1|root,COG0583@2|Bacteria,1MW16@1224|Proteobacteria,2VK4X@28216|Betaproteobacteria,1K4Z0@119060|Burkholderiaceae 28216|Betaproteobacteria K LysR family - - - - - - - - - - - - HTH_1,LysR_substrate k59_52738_1 1122137.AQXF01000004_gene1819 3.16e-226 633.0 COG4536@1|root,COG4536@2|Bacteria,1NZ99@1224|Proteobacteria,2TVZH@28211|Alphaproteobacteria 28211|Alphaproteobacteria P Mg2 and Co2 transporter CorB corB GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K03699 - - - - ko00000,ko02042 - - - CBS,CorC_HlyC,DUF21 k59_670269_1 861299.J421_3811 6.67e-28 116.0 COG1640@1|root,COG1640@2|Bacteria,1ZU23@142182|Gemmatimonadetes 142182|Gemmatimonadetes G 4-alpha-glucanotransferase - - 2.4.1.25 ko:K00705 ko00500,ko01100,map00500,map01100 - R05196 RC00049 ko00000,ko00001,ko01000 - GH77 - Glyco_hydro_77 k59_1007686_1 314287.GB2207_10818 3.52e-85 258.0 COG0336@1|root,COG0336@2|Bacteria,1MUN1@1224|Proteobacteria,1RMWC@1236|Gammaproteobacteria,1J4M2@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Belongs to the RNA methyltransferase TrmD family trmD GO:0000287,GO:0001510,GO:0002939,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009019,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0016772,GO:0016779,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0050518,GO:0052906,GO:0070567,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.1.1.228 ko:K00554 - - R00597 RC00003,RC00334 ko00000,ko01000,ko03016 - - - tRNA_m1G_MT k59_220341_1 1081640.AGFU01000059_gene266 1.41e-63 213.0 COG1629@1|root,COG1629@2|Bacteria,1MV8W@1224|Proteobacteria,2TURS@28211|Alphaproteobacteria,2JZWC@204457|Sphingomonadales 204457|Sphingomonadales P TonB-dependent Receptor Plug Domain - - - - - - - - - - - - Plug,TonB_dep_Rec k59_1632662_1 1229909.NSED_06330 2.04e-88 268.0 COG0505@1|root,arCOG00064@2157|Archaea,41SF0@651137|Thaumarchaeota 651137|Thaumarchaeota E carbamoyl-phosphate synthase, small subunit carA - 6.3.5.5 ko:K01956 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - - CPSase_sm_chain,GATase k59_444010_1 1122137.AQXF01000007_gene3583 2.26e-93 286.0 COG0591@1|root,COG0591@2|Bacteria,1MUBI@1224|Proteobacteria,2VF3C@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family - - - ko:K11928 - - - - ko00000,ko02000 2.A.21.2 - - SSF k59_163196_1 395961.Cyan7425_3096 2e-49 169.0 COG3328@1|root,COG3328@2|Bacteria,1G3YG@1117|Cyanobacteria 1117|Cyanobacteria L PFAM transposase mutator type - - - - - - - - - - - - Transposase_mut k59_790100_2 187272.Mlg_0402 9.73e-10 59.3 COG1466@1|root,COG1466@2|Bacteria,1MWYT@1224|Proteobacteria,1RQRE@1236|Gammaproteobacteria,1WWRB@135613|Chromatiales 135613|Chromatiales L DNA polymerase III, delta subunit - - 2.7.7.7 ko:K02340 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_delt_C,DNA_pol3_delta k59_1016459_1 1122137.AQXF01000001_gene3288 2.76e-51 174.0 COG2821@1|root,COG2821@2|Bacteria,1MXD4@1224|Proteobacteria,2TS5S@28211|Alphaproteobacteria 28211|Alphaproteobacteria M membrane-bound lytic murein transglycosylase mltA - - ko:K08304 - - - - ko00000,ko01000,ko01011 - GH102 - 3D,MltA k59_1016459_2 1122137.AQXF01000001_gene3289 7.52e-85 256.0 COG2840@1|root,COG2840@2|Bacteria,1RH34@1224|Proteobacteria,2UCM1@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Smr protein MutS2 smrA - - - - - - - - - - - Smr k59_508132_1 1461694.ATO9_10430 4.48e-30 109.0 COG2388@1|root,COG2388@2|Bacteria,1N6YS@1224|Proteobacteria,2VCN5@28211|Alphaproteobacteria,2PERH@252301|Oceanicola 28211|Alphaproteobacteria S GCN5-related N-acetyl-transferase - - - - - - - - - - - - Acetyltransf_CG k59_790209_1 247639.MGP2080_01861 8.53e-59 212.0 COG4206@1|root,COG4206@2|Bacteria,1MUZG@1224|Proteobacteria,1RP7I@1236|Gammaproteobacteria,1J4FA@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H COG1629 Outer membrane receptor proteins, mostly Fe transport - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_790237_1 376686.Fjoh_3243 3.46e-59 195.0 COG3384@1|root,COG3384@2|Bacteria,4NFGT@976|Bacteroidetes,1HX1P@117743|Flavobacteriia,2NS8H@237|Flavobacterium 976|Bacteroidetes S in asymptomatic bacteriuria E. coli strains 83972 and VR50, the ygiD gene is upregulated during biofilm formation in urine - - - ko:K15777 ko00965,map00965 - R08836 RC00387 ko00000,ko00001,ko01000 - - - LigB k59_1016564_1 1207058.L53_09205 5.17e-123 374.0 COG0004@1|root,COG1496@1|root,COG0004@2|Bacteria,COG1496@2|Bacteria,1NR9F@1224|Proteobacteria,2TT2J@28211|Alphaproteobacteria,43WQ0@69657|Hyphomonadaceae 28211|Alphaproteobacteria P ammonium transporter amtB - - ko:K03320 - - - - ko00000,ko02000 1.A.11 - - Ammonium_transp k59_1016564_2 1479238.JQMZ01000001_gene2483 2.29e-26 107.0 COG0556@1|root,COG0556@2|Bacteria,1MUFK@1224|Proteobacteria,2TQSP@28211|Alphaproteobacteria,43WPF@69657|Hyphomonadaceae 28211|Alphaproteobacteria L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage uvrB - - ko:K03702 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - Helicase_C,ResIII,UVR,UvrB k59_564294_1 1122137.AQXF01000002_gene555 2.63e-100 309.0 COG0477@1|root,COG2814@2|Bacteria,1R44K@1224|Proteobacteria 1224|Proteobacteria EGP Transmembrane secretion effector - - - - - - - - - - - - MFS_1 k59_564294_2 1535422.ND16A_2265 2.93e-49 169.0 COG4798@1|root,COG4798@2|Bacteria,1RHGZ@1224|Proteobacteria,1S2WK@1236|Gammaproteobacteria,2Q6UK@267889|Colwelliaceae 1236|Gammaproteobacteria S Methyl-transferase - - - - - - - - - - - - Methyltransf_11,PCMT,Ubie_methyltran k59_1355753_1 1453503.AU05_04065 1.73e-32 122.0 COG3675@1|root,COG3675@2|Bacteria,1NICA@1224|Proteobacteria,1SHG9@1236|Gammaproteobacteria,1YDR8@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria I Lipase (class 3) - - 3.1.1.3 ko:K01046 ko00561,ko01100,map00561,map01100 M00098 R02250,R02687 RC00020,RC00037,RC00041,RC00094 ko00000,ko00001,ko00002,ko01000 - - - Lipase_3 k59_564306_1 745411.B3C1_17262 2.48e-07 53.9 COG2234@1|root,COG2234@2|Bacteria,1NE83@1224|Proteobacteria,1RN9P@1236|Gammaproteobacteria,1J5NE@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S peptidase - - - - - - - - - - - - PA,Peptidase_M28 k59_564306_2 1122194.AUHU01000014_gene1147 2.01e-23 97.8 COG0500@1|root,COG2226@2|Bacteria,1QY1T@1224|Proteobacteria 1224|Proteobacteria Q methyltransferase - - - - - - - - - - - - - k59_508231_1 391735.Veis_4614 6.92e-24 104.0 COG0583@1|root,COG0583@2|Bacteria,1MW16@1224|Proteobacteria,2VIE3@28216|Betaproteobacteria,4AC9Y@80864|Comamonadaceae 28216|Betaproteobacteria K Transcriptional regulator, LysR family - - - - - - - - - - - - HTH_1,LysR_substrate k59_564336_1 136993.KB900626_gene1745 1.49e-51 184.0 COG1075@1|root,COG1075@2|Bacteria,1RCB9@1224|Proteobacteria,2U60Z@28211|Alphaproteobacteria,36Z4X@31993|Methylocystaceae 28211|Alphaproteobacteria S acetyltransferases and hydrolases with the alpha beta hydrolase fold - - 3.1.1.3 ko:K01046 ko00561,ko01100,map00561,map01100 M00098 R02250,R02687 RC00020,RC00037,RC00041,RC00094 ko00000,ko00001,ko00002,ko01000 - - - - k59_564336_2 1122138.AQUZ01000028_gene706 8.05e-50 170.0 COG0500@1|root,COG2226@2|Bacteria,2HF00@201174|Actinobacteria,4DVYR@85009|Propionibacteriales 201174|Actinobacteria Q Pfam:Methyltransf_26 - - - - - - - - - - - - Methyltransf_25 k59_1806015_1 1229909.NSED_06225 1.16e-46 160.0 COG0017@1|root,arCOG00406@2157|Archaea,41S93@651137|Thaumarchaeota 651137|Thaumarchaeota J Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp) - - - - - - - - - - - - tRNA-synt_2,tRNA_anti-codon k59_1806015_2 1229909.NSED_06230 8.15e-42 138.0 arCOG08788@1|root,arCOG08788@2157|Archaea,41T6K@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_508296_1 1120970.AUBZ01000009_gene2076 7.95e-134 405.0 COG3459@1|root,COG3459@2|Bacteria,1MVNX@1224|Proteobacteria,1RMW9@1236|Gammaproteobacteria,465S2@72275|Alteromonadaceae 1236|Gammaproteobacteria G Cellobiose phosphorylase ndvB - 2.4.1.20 ko:K00702,ko:K13688 ko00500,ko01100,map00500,map01100 - R00952 RC00049 ko00000,ko00001,ko01000,ko01003 - GH94,GT36,GT84 - Glyco_hydro_36,Glyco_transf_36,Glycoamylase k59_1016674_1 395964.KE386496_gene1356 3.15e-19 87.8 COG0727@1|root,COG0727@2|Bacteria,1RCAS@1224|Proteobacteria,2U68A@28211|Alphaproteobacteria,3NB05@45404|Beijerinckiaceae 28211|Alphaproteobacteria S Putative zinc- or iron-chelating domain - - - - - - - - - - - - CxxCxxCC k59_508347_1 1278078.G419_05357 1.61e-71 243.0 COG2937@1|root,COG2937@2|Bacteria,2GMQF@201174|Actinobacteria,4FWRE@85025|Nocardiaceae 201174|Actinobacteria I Belongs to the GPAT DAPAT family plsB GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 2.3.1.15 ko:K00631 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R00851,R09380 RC00004,RC00039,RC00041 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Acyltransferase k59_1355863_1 279238.Saro_3436 1.29e-47 167.0 COG3119@1|root,COG3119@2|Bacteria,1MUJH@1224|Proteobacteria,2TSB8@28211|Alphaproteobacteria,2K9FA@204457|Sphingomonadales 204457|Sphingomonadales P Sulfatase - - - - - - - - - - - - Sulfatase k59_508349_1 745310.G432_18105 3.65e-56 198.0 COG1629@1|root,COG1629@2|Bacteria,COG4771@2|Bacteria,1MU9K@1224|Proteobacteria,2TS4W@28211|Alphaproteobacteria,2KEEP@204457|Sphingomonadales 204457|Sphingomonadales P COG1629 Outer membrane receptor proteins, mostly Fe transport - - - - - - - - - - - - Plug,TonB_dep_Rec k59_508388_1 1123237.Salmuc_02723 1.69e-59 206.0 COG0419@1|root,COG0419@2|Bacteria,1QWEJ@1224|Proteobacteria,2U2ID@28211|Alphaproteobacteria 28211|Alphaproteobacteria L ATPase involved in DNA repair - - - - - - - - - - - - AAA_23 k59_1016759_1 1265313.HRUBRA_02318 2.43e-22 100.0 COG2937@1|root,COG2937@2|Bacteria,1MWZ6@1224|Proteobacteria,1RM7K@1236|Gammaproteobacteria,1J527@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria I Belongs to the GPAT DAPAT family plsB - 2.3.1.15 ko:K00631 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R00851,R09380 RC00004,RC00039,RC00041 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Acyltransferase k59_1074350_1 1123073.KB899241_gene1855 2.13e-38 139.0 COG1600@1|root,COG1600@2|Bacteria,1MV1H@1224|Proteobacteria,1RMD9@1236|Gammaproteobacteria,1X3CD@135614|Xanthomonadales 135614|Xanthomonadales C Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) queG GO:0003674,GO:0003824,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0016491,GO:0018130,GO:0019438,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0052693,GO:0055086,GO:0055114,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 1.17.99.6 ko:K18979 - - - - ko00000,ko01000,ko03016 - - - DUF1730,Fer4_16 k59_1244010_1 373903.Hore_14550 1.35e-14 78.2 COG1653@1|root,COG1653@2|Bacteria,1UY8X@1239|Firmicutes 1239|Firmicutes G ABC transporter, substratebinding protein - - - ko:K10232 ko02010,map02010 M00201 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.32,3.A.1.1.8 - - SBP_bac_1 k59_114171_1 305700.B447_06707 9.9e-69 227.0 COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,2VHGH@28216|Betaproteobacteria,2KUY0@206389|Rhodocyclales 206389|Rhodocyclales S COG0488 ATPase components of ABC transporters with duplicated ATPase domains yheS - - ko:K06158 - - - - ko00000,ko03012 - - - ABC_tran,ABC_tran_CTD,ABC_tran_Xtn k59_170693_1 47839.CCAU010000002_gene2724 1.81e-32 122.0 COG1804@1|root,COG1804@2|Bacteria,2GRB0@201174|Actinobacteria,235AT@1762|Mycobacteriaceae 201174|Actinobacteria C PFAM CoA-transferase family III - - - - - - - - - - - - CoA_transf_3 k59_170693_2 1206735.BAGG01000061_gene2656 2.43e-32 123.0 COG1024@1|root,COG1024@2|Bacteria,2HSJH@201174|Actinobacteria,4FXUB@85025|Nocardiaceae 201174|Actinobacteria I Enoyl-CoA hydratase/isomerase - - - - - - - - - - - - ECH_1 k59_735711_1 1229909.NSED_00110 2.85e-201 564.0 COG1903@1|root,arCOG04383@2157|Archaea,41S70@651137|Thaumarchaeota 651137|Thaumarchaeota H Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A cbiD - 2.1.1.195 ko:K02188 ko00860,ko01100,map00860,map01100 - R07773 RC00003,RC02051 ko00000,ko00001,ko01000 - - - CbiD k59_735711_2 436308.Nmar_0084 1.11e-18 83.6 COG0702@1|root,arCOG03015@2157|Archaea,41T19@651137|Thaumarchaeota 651137|Thaumarchaeota M NAD(P)H-binding - - 1.6.5.3,1.6.99.3 ko:K00329,ko:K00356 ko00190,map00190 - R11945 RC00061 ko00000,ko00001,ko01000 - - - NAD_binding_10 k59_1100_1 1094184.KWO_0102550 9.5e-10 59.3 COG4675@1|root,COG4675@2|Bacteria,1MZY9@1224|Proteobacteria,1S64Y@1236|Gammaproteobacteria,1X6ER@135614|Xanthomonadales 135614|Xanthomonadales S Phage Tail Collar Domain - - - - - - - - - - - - Collar k59_1100_2 211586.SO_0185 1.29e-33 125.0 COG4675@1|root,COG4675@2|Bacteria,1MZY9@1224|Proteobacteria,1S64Y@1236|Gammaproteobacteria,2QCM9@267890|Shewanellaceae 1236|Gammaproteobacteria S Phage Tail Collar Domain - - - - - - - - - - - - Collar k59_1526482_1 926559.JoomaDRAFT_0387 3.55e-90 276.0 COG4225@1|root,COG4225@2|Bacteria,4NHM1@976|Bacteroidetes,1HY88@117743|Flavobacteriia 976|Bacteroidetes S BNR repeat-containing family member - - - - - - - - - - - - BNR_4 k59_848583_1 519989.ECTPHS_13183 2.75e-93 282.0 COG0202@1|root,COG0202@2|Bacteria,1MU75@1224|Proteobacteria,1RMU3@1236|Gammaproteobacteria,1WWB2@135613|Chromatiales 135613|Chromatiales K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoA - 2.7.7.6 ko:K03040 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_A_CTD,RNA_pol_A_bac,RNA_pol_L k59_227107_2 105422.BBPM01000058_gene4563 3.79e-88 286.0 COG0243@1|root,COG0243@2|Bacteria,2GNYQ@201174|Actinobacteria,2NEZM@228398|Streptacidiphilus 201174|Actinobacteria C Molybdopterin oxidoreductase Fe4S4 domain - - - - - - - - - - - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding k59_57781_1 1238182.C882_0771 4.75e-110 325.0 COG2189@1|root,COG2189@2|Bacteria,1MX9M@1224|Proteobacteria,2TSW9@28211|Alphaproteobacteria,2JPYW@204441|Rhodospirillales 204441|Rhodospirillales L Belongs to the N(4) N(6)-methyltransferase family ccrM - 2.1.1.72 ko:K13581 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko02048 - - - N6_N4_Mtase k59_114187_1 1459636.NTE_00007 1.88e-129 394.0 COG0417@1|root,arCOG00329@2157|Archaea 2157|Archaea L DNA polymerase elongation subunit (Family B) polB2 - 2.7.7.7 ko:K02319 ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032 - - - DNA_pol_B k59_904954_1 1122137.AQXF01000001_gene2788 3e-44 161.0 COG0060@1|root,COG0060@2|Bacteria,1MVBQ@1224|Proteobacteria,2TR3N@28211|Alphaproteobacteria 28211|Alphaproteobacteria J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) ileS - 6.1.1.5 ko:K01870 ko00970,map00970 M00359,M00360 R03656 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,tRNA-synt_1,zf-FPG_IleRS k59_904954_2 1408418.JNJH01000031_gene3381 1.05e-09 57.8 COG0597@1|root,COG0597@2|Bacteria,1RGV9@1224|Proteobacteria,2UBUC@28211|Alphaproteobacteria,2JTBQ@204441|Rhodospirillales 204441|Rhodospirillales MU This protein specifically catalyzes the removal of signal peptides from prolipoproteins lspA - 3.4.23.36 ko:K03101 ko03060,map03060 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_A8 k59_679073_1 105559.Nwat_0242 6.11e-228 636.0 COG0205@1|root,COG0205@2|Bacteria,1MVN3@1224|Proteobacteria,1RMVY@1236|Gammaproteobacteria,1WWG7@135613|Chromatiales 135613|Chromatiales G Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions pfp - 2.7.1.11,2.7.1.90 ko:K21071 ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130 - R00756,R00764,R02073,R03236,R04779 RC00002,RC00017 ko00000,ko00001,ko01000 - - - PFK k59_679073_2 998674.ATTE01000001_gene1029 7.01e-41 141.0 COG0563@1|root,COG0563@2|Bacteria,1MXCZ@1224|Proteobacteria,1RMT6@1236|Gammaproteobacteria,460EA@72273|Thiotrichales 72273|Thiotrichales F Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism adk - 2.7.4.3 ko:K00939 ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130 M00049 R00127,R01547,R11319 RC00002 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ADK,ADK_lid k59_1131135_1 227377.CBU_1129 1.89e-43 155.0 COG1104@1|root,COG1104@2|Bacteria,1MU1C@1224|Proteobacteria,1RNCD@1236|Gammaproteobacteria,1JCQ8@118969|Legionellales 118969|Legionellales H Aminotransferase class-V iscS - 2.8.1.7 ko:K04487 ko00730,ko01100,ko04122,map00730,map01100,map04122 - R07460,R11528,R11529 RC01789,RC02313 ko00000,ko00001,ko01000,ko02048,ko03016,ko03029 - - - Aminotran_5 k59_452976_1 68223.JNZY01000013_gene520 6.33e-08 61.2 COG0515@1|root,COG0515@2|Bacteria,2GJTV@201174|Actinobacteria 201174|Actinobacteria KLT Serine threonine protein kinase pkaE - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase,TPR_19 k59_792255_1 1535422.ND16A_2119 3.09e-16 73.9 COG2827@1|root,COG2827@2|Bacteria,1N6PA@1224|Proteobacteria,1SCBH@1236|Gammaproteobacteria,2Q7CU@267889|Colwelliaceae 1236|Gammaproteobacteria L GIY-YIG catalytic domain yhbQ GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004527,GO:0004529,GO:0004536,GO:0006139,GO:0006259,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008296,GO:0008408,GO:0009987,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360 - ko:K07461 - - - - ko00000 - - - GIY-YIG k59_792255_2 1415778.JQMM01000001_gene1041 4.45e-35 124.0 2CJPW@1|root,32SAH@2|Bacteria,1NAJ3@1224|Proteobacteria,1SAPE@1236|Gammaproteobacteria,1JAHP@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_1413511_1 1192034.CAP_6254 5.04e-48 167.0 COG1376@1|root,COG1376@2|Bacteria 2|Bacteria D ErfK ybiS ycfS ynhG family protein enhA_1 - - - - - - - - - - - PG_binding_4,YkuD k59_904962_1 1122207.MUS1_03780 1.17e-56 197.0 COG0249@1|root,COG0249@2|Bacteria,1MUGX@1224|Proteobacteria,1RNW3@1236|Gammaproteobacteria,1XI9K@135619|Oceanospirillales 135619|Oceanospirillales L that it carries out the mismatch recognition step. This protein has a weak ATPase activity mutS - - ko:K03555 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V k59_1244051_1 1042377.AFPJ01000014_gene1669 5.21e-159 456.0 COG0621@1|root,COG0621@2|Bacteria,1MURS@1224|Proteobacteria,1RMD8@1236|Gammaproteobacteria,4643J@72275|Alteromonadaceae 1236|Gammaproteobacteria J Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine miaB GO:0001510,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016782,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0035596,GO:0035597,GO:0035600,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050497,GO:0051536,GO:0051539,GO:0051540,GO:0071704,GO:0090304,GO:1901360 2.8.4.3 ko:K06168 - - R10645,R10646,R10647 RC00003,RC00980,RC03221,RC03222 ko00000,ko01000,ko03016 - - - Radical_SAM,TRAM,UPF0004 k59_1300753_1 436308.Nmar_0746 1.88e-38 135.0 COG2107@1|root,arCOG00654@2157|Archaea,41SB8@651137|Thaumarchaeota 651137|Thaumarchaeota H Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2) mqnD - - ko:K11785 ko00130,ko01110,map00130,map01110 - R08589 RC02330 ko00000,ko00001,ko01000 - - - VitK2_biosynth k59_1300753_2 436308.Nmar_0745 8e-53 167.0 arCOG10539@1|root,arCOG10539@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_57804_1 1229909.NSED_00710 3.3e-50 167.0 COG0040@1|root,arCOG02208@2157|Archaea,41SCJ@651137|Thaumarchaeota 651137|Thaumarchaeota E ATP phosphoribosyltransferase - - 2.4.2.17 ko:K00765 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R01071 RC02819,RC03200 ko00000,ko00001,ko00002,ko01000 - - - HisG,HisG_C k59_57804_2 1229909.NSED_00715 9.35e-34 128.0 COG0141@1|root,arCOG04352@2157|Archaea,41S6J@651137|Thaumarchaeota 651137|Thaumarchaeota E Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine hisD - 1.1.1.23 ko:K00013 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R01158,R01163,R03012 RC00099,RC00242,RC00463 ko00000,ko00001,ko00002,ko01000 - - - Histidinol_dh k59_340244_1 998674.ATTE01000001_gene2504 2.44e-57 186.0 COG0861@1|root,COG0861@2|Bacteria,1MWC9@1224|Proteobacteria,1T1GE@1236|Gammaproteobacteria,460Y0@72273|Thiotrichales 72273|Thiotrichales P Integral membrane protein TerC family - - - - - - - - - - - - TerC k59_170742_1 2340.JV46_16340 3.06e-78 257.0 COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,1RNBG@1236|Gammaproteobacteria,1J4YE@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity polA GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008408,GO:0008409,GO:0009058,GO:0009059,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901362,GO:1901363,GO:1901576 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1 k59_904971_1 396595.TK90_0766 1.05e-48 165.0 COG0558@1|root,COG0558@2|Bacteria,1N1AE@1224|Proteobacteria,1SBCI@1236|Gammaproteobacteria 1236|Gammaproteobacteria I Belongs to the CDP-alcohol phosphatidyltransferase class-I family - - - - - - - - - - - - CDP-OH_P_transf k59_452994_1 1280949.HAD_05020 1.49e-29 122.0 COG2366@1|root,COG2366@2|Bacteria,1MVMH@1224|Proteobacteria,2TS4D@28211|Alphaproteobacteria,43ZK1@69657|Hyphomonadaceae 28211|Alphaproteobacteria S COG2366 Protein related to penicillin acylase - - 3.5.1.11,3.5.1.97 ko:K01434,ko:K07116 ko00311,ko01130,map00311,map01130 - R02170 RC00166,RC00328 ko00000,ko00001,ko01000,ko01002 - - - Penicil_amidase k59_57819_1 398579.Spea_3233 3.01e-17 86.3 2C3QV@1|root,2Z7YP@2|Bacteria,1MXAM@1224|Proteobacteria,1RNIA@1236|Gammaproteobacteria,2Q9Z9@267890|Shewanellaceae 1236|Gammaproteobacteria S Alginate export - - - - - - - - - - - - Alginate_exp k59_1300771_1 314265.R2601_01563 7.16e-29 119.0 COG1172@1|root,COG1172@2|Bacteria,1MX1K@1224|Proteobacteria,2TUYJ@28211|Alphaproteobacteria 28211|Alphaproteobacteria G Belongs to the binding-protein-dependent transport system permease family - - - ko:K10440 ko02010,map02010 M00212 - - ko00000,ko00001,ko00002,ko02000 3.A.1.2.1,3.A.1.2.13,3.A.1.2.19 - - BPD_transp_2 k59_1300771_2 105422.BBPM01000017_gene2346 1.23e-18 90.1 COG0402@1|root,COG0402@2|Bacteria,2GNUN@201174|Actinobacteria,2NMHQ@228398|Streptacidiphilus 201174|Actinobacteria F Amidohydrolase family - - - - - - - - - - - - Amidohydro_1 k59_283875_1 1347342.BN863_32640 7.74e-72 238.0 COG0457@1|root,COG0457@2|Bacteria,4NGS0@976|Bacteroidetes,1HZ2N@117743|Flavobacteriia 976|Bacteroidetes K Tetratricopeptide repeat - - - - - - - - - - - - GerE,TPR_12,TPR_7,TPR_8 k59_1139_1 930169.B5T_01630 6.26e-31 122.0 COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,1RMBQ@1236|Gammaproteobacteria,1XHTV@135619|Oceanospirillales 135619|Oceanospirillales C belongs to the aldehyde dehydrogenase family aldh1 - 1.2.1.3 ko:K00128 ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130 M00135 R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146 RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_792282_1 697282.Mettu_3669 7.09e-24 97.8 COG2084@1|root,COG2084@2|Bacteria,1NS71@1224|Proteobacteria,1S043@1236|Gammaproteobacteria,1XEIU@135618|Methylococcales 135618|Methylococcales C 6-phosphogluconate dehydrogenase - - 1.1.1.31 ko:K00020 ko00280,ko01100,map00280,map01100 - R05066 RC00099 ko00000,ko00001,ko01000 - - - NAD_binding_11,NAD_binding_2 k59_792282_2 525904.Tter_0196 7.88e-28 113.0 COG0129@1|root,COG0129@2|Bacteria,2NNSM@2323|unclassified Bacteria 2|Bacteria EG Belongs to the IlvD Edd family ilvD GO:0003674,GO:0003824,GO:0004160,GO:0016829,GO:0016835,GO:0016836 4.2.1.9 ko:K01687 ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R01209,R04441,R05070 RC00468,RC01714 ko00000,ko00001,ko00002,ko01000 - - - ILVD_EDD k59_1074407_1 983920.Y88_1953 8.95e-130 392.0 COG0187@1|root,COG0187@2|Bacteria,1MVKT@1224|Proteobacteria,2TRBK@28211|Alphaproteobacteria,2K0E4@204457|Sphingomonadales 204457|Sphingomonadales L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrB - 5.99.1.3 ko:K02470 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim k59_679118_1 237368.SCABRO_01998 7.31e-116 351.0 COG1008@1|root,COG1008@2|Bacteria,2IX79@203682|Planctomycetes 203682|Planctomycetes C proton-translocating NADH-quinone oxidoreductase, chain M - - 1.6.5.3 ko:K00342 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q5_N,Proton_antipo_M k59_1639526_1 227377.CBU_0353 5.94e-30 118.0 COG0616@1|root,COG0616@2|Bacteria,1MUXE@1224|Proteobacteria,1RNN9@1236|Gammaproteobacteria,1JD28@118969|Legionellales 118969|Legionellales OU Peptidase family S49 N-terminal sohB - - ko:K04774 - - - - ko00000,ko01000,ko01002 - - - Peptidase_S49,Peptidase_S49_N k59_1695975_1 158500.BV97_01461 3.78e-107 339.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2TQT0@28211|Alphaproteobacteria,2K02H@204457|Sphingomonadales 204457|Sphingomonadales V Efflux pump membrane transporter - - - ko:K18138 ko01501,ko01503,map01501,map01503 M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000 2.A.6.2 - - ACR_tran k59_1074414_1 1049564.TevJSym_cz00010 1.27e-98 297.0 COG3177@1|root,COG3177@2|Bacteria,1MV69@1224|Proteobacteria,1RM9J@1236|Gammaproteobacteria,1J5EA@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Domain of unknown function (DUF4172) - - - - - - - - - - - - DUF4172,Fic k59_1244106_1 477974.Daud_1872 1.56e-44 158.0 COG0263@1|root,COG0263@2|Bacteria,1TPG6@1239|Firmicutes,2486P@186801|Clostridia,260P5@186807|Peptococcaceae 186801|Clostridia E Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate proB - 2.7.2.11 ko:K00931 ko00330,ko00332,ko01100,ko01130,ko01230,map00330,map00332,map01100,map01130,map01230 M00015 R00239 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase,PUA k59_848672_1 640081.Dsui_0888 5.59e-192 537.0 COG1077@1|root,COG1077@2|Bacteria,1MUMW@1224|Proteobacteria,2VIR9@28216|Betaproteobacteria,2KUHG@206389|Rhodocyclales 206389|Rhodocyclales D Rod shape-determining protein MreB mreB - - ko:K03569 - - - - ko00000,ko02048,ko03036,ko04812 1.A.33.1,9.B.157.1 - - MreB_Mbl k59_848672_2 1562701.BBOF01000061_gene1725 6.37e-16 79.3 COG1792@1|root,COG1792@2|Bacteria,1N8ZS@1224|Proteobacteria,2VK0Y@28216|Betaproteobacteria,1K372@119060|Burkholderiaceae 28216|Betaproteobacteria M shape-determining protein MreC mreC - - ko:K03570 - - - - ko00000,ko03036 9.B.157.1 - - MreC k59_961516_1 420324.KI911970_gene1445 1.02e-23 101.0 COG0258@1|root,COG0258@2|Bacteria,1MYSI@1224|Proteobacteria,2U60N@28211|Alphaproteobacteria 28211|Alphaproteobacteria L 5'-3' exonuclease, N-terminal resolvase-like domain - - 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc_N k59_396690_1 1121921.KB898711_gene1919 1.59e-47 172.0 COG1197@1|root,COG1197@2|Bacteria,1MUXG@1224|Proteobacteria,1RNCU@1236|Gammaproteobacteria,2PMXA@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria L TRCF mfd GO:0000715,GO:0000716,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006283,GO:0006289,GO:0006355,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008094,GO:0008150,GO:0008152,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0015616,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019219,GO:0019222,GO:0019899,GO:0031323,GO:0031326,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0043175,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0051276,GO:0051716,GO:0060255,GO:0065007,GO:0070063,GO:0071704,GO:0071840,GO:0080090,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1903506,GO:2000112,GO:2001141 - ko:K03723 ko03420,map03420 - - - ko00000,ko00001,ko01000,ko03400 - - - CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF k59_1168_1 338963.Pcar_3052 4.12e-68 225.0 COG3666@1|root,COG3666@2|Bacteria,1N3QR@1224|Proteobacteria,42N7X@68525|delta/epsilon subdivisions,2WMM9@28221|Deltaproteobacteria 28221|Deltaproteobacteria L Transposase DDE domain - - - - - - - - - - - - DDE_Tnp_1,DDE_Tnp_1_6,DUF772 k59_1192558_1 1121007.AUML01000002_gene1713 7.34e-71 238.0 COG0584@1|root,COG4222@1|root,COG0584@2|Bacteria,COG4222@2|Bacteria,4NGI1@976|Bacteroidetes,1I0PI@117743|Flavobacteriia,2YGYQ@290174|Aquimarina 976|Bacteroidetes C Esterase-like activity of phytase glpQ - 3.1.4.46 ko:K01126 ko00564,map00564 - R01030,R01470 RC00017,RC00425 ko00000,ko00001,ko01000 - - - GDPD k59_401521_1 375451.RD1_3335 5.06e-20 88.2 COG0824@1|root,COG0824@2|Bacteria,1MZB3@1224|Proteobacteria,2U7CU@28211|Alphaproteobacteria,2P39Q@2433|Roseobacter 28211|Alphaproteobacteria S Thioesterase-like superfamily - - - ko:K07107 - - - - ko00000,ko01000 - - - 4HBT_2 k59_401521_2 272560.BPSL1425 8.99e-65 203.0 COG1335@1|root,COG1335@2|Bacteria,1MUGW@1224|Proteobacteria,2VIMK@28216|Betaproteobacteria,1JZX0@119060|Burkholderiaceae 28216|Betaproteobacteria Q Nicotinamidase pncA - 3.5.1.19 ko:K08281 ko00760,ko01100,map00760,map01100 - R01268 RC00100 ko00000,ko00001,ko01000 - - - Isochorismatase k59_1023507_1 1088721.NSU_1162 4.45e-09 56.2 COG0122@1|root,COG0122@2|Bacteria,1MX9C@1224|Proteobacteria,2TVJ7@28211|Alphaproteobacteria,2K0I0@204457|Sphingomonadales 204457|Sphingomonadales L COG0122 3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase - - 3.2.2.21 ko:K01247 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - HhH-GPD k59_1023507_2 702113.PP1Y_AT7331 1.08e-61 190.0 COG0633@1|root,COG0633@2|Bacteria,1N261@1224|Proteobacteria,2UC7B@28211|Alphaproteobacteria,2K5DE@204457|Sphingomonadales 204457|Sphingomonadales C ferredoxin - - - ko:K04755 - - - - ko00000 - - - Fer2 k59_1362008_1 1123501.KB902294_gene3529 1.45e-77 251.0 COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,2TVI3@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Protein conserved in bacteria - - - - - - - - - - - - TctA k59_1248899_1 1229909.NSED_09770 4.31e-103 304.0 COG1028@1|root,arCOG01259@2157|Archaea,41SXY@651137|Thaumarchaeota 651137|Thaumarchaeota I Short-chain dehydrogenase reductase SDR - - 1.1.1.100 ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 k59_1644700_1 436308.Nmar_1679 1.37e-13 68.9 arCOG08818@1|root,arCOG08818@2157|Archaea,41SVV@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1644700_2 1229909.NSED_09875 3.85e-161 457.0 COG2046@1|root,arCOG04191@2157|Archaea,41SER@651137|Thaumarchaeota 651137|Thaumarchaeota P Belongs to the sulfate adenylyltransferase family sat - 2.7.7.4 ko:K00958 ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130 M00176,M00596 R00529,R04929 RC02809,RC02889 ko00000,ko00001,ko00002,ko01000 - - - ATP-sulfurylase,PUA_2 k59_853839_1 1122225.AULQ01000001_gene1464 5.03e-88 270.0 COG1207@1|root,COG1207@2|Bacteria,4NDZP@976|Bacteroidetes,1HWW0@117743|Flavobacteriia 976|Bacteroidetes M glucose-1-phosphate thymidylyltransferase glmU - - - - - - - - - - - NTP_transf_4 k59_1475200_1 323261.Noc_0785 8.06e-96 293.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,1WW4B@135613|Chromatiales 135613|Chromatiales T response regulator - - - ko:K07715 ko02020,ko02024,map02020,map02024 M00502 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Sigma54_activat k59_1135865_1 511145.b2873 1.05e-126 370.0 COG0044@1|root,COG0044@2|Bacteria,1MW10@1224|Proteobacteria,1RMQC@1236|Gammaproteobacteria,3XMJE@561|Escherichia 1236|Gammaproteobacteria F Catalyzes the stereospecific hydrolysis of the cyclic amide bond of D-hydantoin derivatives with an aromatic side chains at the 5'-position. Has no activity on dihydropyrimidines. The physiological function is hyuA GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0016787,GO:0016810,GO:0016812,GO:0042802 3.5.2.2 ko:K01464 ko00240,ko00410,ko00770,ko00983,ko01100,map00240,map00410,map00770,map00983,map01100 M00046 R02269,R03055,R08227 RC00632,RC00680 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Amidohydro_1 k59_346592_1 1082705.JIBP01000020_gene1816 1.79e-07 58.2 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,1RMH0@1236|Gammaproteobacteria 1236|Gammaproteobacteria NT chemotaxis, protein aer - - ko:K03406,ko:K03776 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - 4HB_MCP_1,CZB,HAMP,MCPsignal,PAS,PAS_3,PAS_9,TarH k59_1701728_1 1163407.UU7_04362 2.98e-69 221.0 COG0150@1|root,COG0150@2|Bacteria,1MURG@1224|Proteobacteria,1RNZZ@1236|Gammaproteobacteria,1X33C@135614|Xanthomonadales 135614|Xanthomonadales F Phosphoribosylformylglycinamidine cyclo-ligase purM - 6.3.3.1 ko:K01933 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04208 RC01100 ko00000,ko00001,ko00002,ko01000 - - - AIRS,AIRS_C k59_176481_1 59538.XP_005960400.1 2.55e-70 227.0 COG0318@1|root,KOG1176@2759|Eukaryota,38GCS@33154|Opisthokonta,3BD3H@33208|Metazoa,3CS1H@33213|Bilateria,4898P@7711|Chordata,497K4@7742|Vertebrata,3J9E1@40674|Mammalia 33208|Metazoa I acyl-CoA synthetase family member 3 - - 6.2.1.8 ko:K18661,ko:K22133 ko00280,ko00630,ko01100,map00280,map00630,map01100 - R01558,R03383 RC00004,RC00137,RC00179 ko00000,ko00001,ko01000 - - - AMP-binding,AMP-binding_C k59_120503_1 674977.VMC_29220 1.84e-31 122.0 COG1968@1|root,COG1968@2|Bacteria,1MX02@1224|Proteobacteria,1RQQT@1236|Gammaproteobacteria,1XSIU@135623|Vibrionales 135623|Vibrionales V Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin uppP - 3.6.1.27 ko:K06153 ko00550,map00550 - R05627 RC00002 ko00000,ko00001,ko01000,ko01011 - - - BacA k59_1701740_1 436308.Nmar_0537 8.66e-122 359.0 COG3635@1|root,arCOG01696@2157|Archaea,41S6M@651137|Thaumarchaeota 651137|Thaumarchaeota G phosphoglycerate mutase - - 5.4.2.12 ko:K15635 ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003 R01518 RC00536 ko00000,ko00001,ko00002,ko01000 - - - Metalloenzyme,PhosphMutase k59_1419246_1 1122137.AQXF01000006_gene910 5.23e-97 295.0 COG0745@1|root,COG2199@1|root,COG0745@2|Bacteria,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria,2TQQM@28211|Alphaproteobacteria 28211|Alphaproteobacteria T response regulator containing a CheY-like receiver domain and a GGDEF domain pleD GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0042802,GO:0044424,GO:0044464 2.7.7.65 ko:K02488 ko02020,ko04112,map02020,map04112 M00511 R08057 - ko00000,ko00001,ko00002,ko01000,ko02022 - - - GGDEF,Response_reg k59_120506_1 1415778.JQMM01000001_gene6 4.78e-33 120.0 COG0603@1|root,COG0603@2|Bacteria,1MU5V@1224|Proteobacteria,1RMG9@1236|Gammaproteobacteria,1J4T0@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria F Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) queC - 6.3.4.20 ko:K06920 ko00790,ko01100,map00790,map01100 - R09978 RC00959 ko00000,ko00001,ko01000,ko03016 - - - QueC k59_120506_2 1121937.AUHJ01000007_gene1912 1.62e-97 289.0 COG0602@1|root,COG0602@2|Bacteria,1MUJ2@1224|Proteobacteria,1RNQZ@1236|Gammaproteobacteria,464EB@72275|Alteromonadaceae 1236|Gammaproteobacteria H Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds queE - 4.3.99.3 ko:K10026 ko00790,ko01100,map00790,map01100 - R10002 RC02989 ko00000,ko00001,ko01000,ko03016 - - - Fer4_14,Radical_SAM k59_1306844_1 743721.Psesu_2469 1.83e-17 82.4 COG0179@1|root,COG0179@2|Bacteria,1MV0V@1224|Proteobacteria,1RNYV@1236|Gammaproteobacteria,1X4ZT@135614|Xanthomonadales 135614|Xanthomonadales Q 2-keto-4-pentenoate hydratase uptA - 3.7.1.2 ko:K16171 ko00350,ko00643,ko01100,ko01120,map00350,map00643,map01100,map01120 M00044 R01364 RC00326,RC00446 ko00000,ko00001,ko00002,ko01000 - - - FAA_hydrolase k59_1306844_2 1207055.C100_16805 1.1e-145 421.0 COG2514@1|root,COG2514@2|Bacteria,1QURE@1224|Proteobacteria,2TW59@28211|Alphaproteobacteria,2K2KW@204457|Sphingomonadales 204457|Sphingomonadales S Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - - - - - - - - - - Glyoxalase k59_176492_1 1123518.ARWI01000001_gene1889 2.19e-26 107.0 COG3219@1|root,COG3219@2|Bacteria,1R8C9@1224|Proteobacteria,1S23S@1236|Gammaproteobacteria,46103@72273|Thiotrichales 72273|Thiotrichales S protein conserved in bacteria - - - ko:K09929 - - - - ko00000 - - - DUF2063 k59_911154_1 436308.Nmar_0625 6.96e-16 74.7 COG1920@1|root,arCOG04472@2157|Archaea,41SPV@651137|Thaumarchaeota 651137|Thaumarchaeota H Guanylyl transferase CofC like - - 2.7.7.68 ko:K14941 ko00680,ko01120,map00680,map01120 M00378 R09397 RC00002 ko00000,ko00001,ko00002,ko01000 - - - CofC k59_911154_2 1229909.NSED_03215 8.74e-88 264.0 COG1405@1|root,arCOG01981@2157|Archaea,41SXZ@651137|Thaumarchaeota 651137|Thaumarchaeota K Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB) - - - ko:K03124 ko03022,ko05169,ko05203,map03022,map05169,map05203 - - - ko00000,ko00001,ko03021 - - - TFIIB,TF_Zn_Ribbon k59_346624_1 1415778.JQMM01000001_gene1820 3.8e-75 246.0 COG2274@1|root,COG2274@2|Bacteria,1R2T0@1224|Proteobacteria,1SBE1@1236|Gammaproteobacteria,1J5FP@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria V COG2274 ABC-type bacteriocin lantibiotic exporters, contain an N-terminal double-glycine peptidase domain lapB - - ko:K12541 ko02010,map02010 M00330 - - ko00000,ko00001,ko00002,ko02000,ko02044 3.A.1.109.3,3.A.1.109.4 - - ABC_membrane,ABC_tran,Peptidase_C39 k59_1645827_1 64471.sync_0372 1.75e-70 226.0 COG0436@1|root,COG0436@2|Bacteria,1G0NC@1117|Cyanobacteria,1GYP3@1129|Synechococcus 1117|Cyanobacteria H Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate dapL - 2.6.1.83 ko:K10206 ko00300,ko01100,ko01110,ko01130,ko01230,map00300,map01100,map01110,map01130,map01230 M00527 R07613 RC00006,RC01847 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 k59_1645827_2 1125863.JAFN01000001_gene2363 3.96e-05 47.0 COG2082@1|root,COG2138@1|root,COG2082@2|Bacteria,COG2138@2|Bacteria,1MX1E@1224|Proteobacteria,42RIY@68525|delta/epsilon subdivisions,2WN0J@28221|Deltaproteobacteria 28221|Deltaproteobacteria H PFAM Precorrin-8X methylmutase CbiC CobH cbiC - 5.4.99.60,5.4.99.61 ko:K06042 ko00860,ko01100,map00860,map01100 - R05177,R05814 RC01292,RC01980 ko00000,ko00001,ko01000 - - - CbiC k59_7464_1 1122137.AQXF01000004_gene1841 1.31e-35 125.0 COG5319@1|root,COG5319@2|Bacteria,1MZN2@1224|Proteobacteria,2UBTA@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Protein conserved in bacteria MA20_39715 - - - - - - - - - - - DUF1178 k59_7464_2 1122137.AQXF01000004_gene1842 9.83e-42 147.0 COG2207@1|root,COG2207@2|Bacteria,1RJPK@1224|Proteobacteria,2TWT6@28211|Alphaproteobacteria 28211|Alphaproteobacteria K helix_turn_helix, arabinose operon control protein - - - ko:K07506 - - - - ko00000,ko03000 - - - HTH_18 k59_684865_2 1382306.JNIM01000001_gene3478 2.3e-69 229.0 COG0028@1|root,COG0028@2|Bacteria,2G7NZ@200795|Chloroflexi 200795|Chloroflexi EH Belongs to the TPP enzyme family - - - - - - - - - - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N,adh_short k59_459053_1 445972.ANACOL_00429 7.35e-10 60.8 COG0215@1|root,COG0215@2|Bacteria,1TP9D@1239|Firmicutes,247KS@186801|Clostridia,3WHD2@541000|Ruminococcaceae 186801|Clostridia J Belongs to the class-I aminoacyl-tRNA synthetase family cysS - 6.1.1.16 ko:K01883 ko00970,map00970 M00359,M00360 R03650 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DALR_2,tRNA-synt_1e,tRNA-synt_1g k59_459053_2 670307.HYPDE_35973 1.59e-39 146.0 COG0556@1|root,COG0556@2|Bacteria,1MUFK@1224|Proteobacteria,2TQSP@28211|Alphaproteobacteria,3N6CN@45401|Hyphomicrobiaceae 28211|Alphaproteobacteria L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage uvrB - - ko:K03702 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - Helicase_C,ResIII,UVR,UvrB k59_1476294_1 243233.MCA0098 2.02e-148 433.0 COG0154@1|root,COG0154@2|Bacteria,1MUVQ@1224|Proteobacteria,1RP7E@1236|Gammaproteobacteria,1XDYT@135618|Methylococcales 135618|Methylococcales J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) gatA - 6.3.5.6,6.3.5.7 ko:K02433 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - Amidase k59_1476294_2 1469245.JFBG01000040_gene1722 5.59e-51 174.0 COG0064@1|root,COG0064@2|Bacteria,1MUKG@1224|Proteobacteria,1RP7U@1236|Gammaproteobacteria,1WX4J@135613|Chromatiales 135613|Chromatiales J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) gatB - 6.3.5.6,6.3.5.7 ko:K02434 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - GatB_N,GatB_Yqey k59_346632_1 517722.AEUE01000004_gene919 8.04e-128 395.0 COG1629@1|root,COG1629@2|Bacteria,COG4771@2|Bacteria,1MWKN@1224|Proteobacteria,2TTI2@28211|Alphaproteobacteria,2K0SD@204457|Sphingomonadales 204457|Sphingomonadales P COG1629 Outer membrane receptor proteins, mostly Fe transport - - - - - - - - - - - - Plug,TonB_dep_Rec k59_346632_2 744980.TRICHSKD4_6193 8.34e-119 342.0 COG2057@1|root,COG2057@2|Bacteria,1RA4V@1224|Proteobacteria,2TQS5@28211|Alphaproteobacteria 28211|Alphaproteobacteria I COG2057 Acyl CoA acetate 3-ketoacid CoA transferase, beta subunit scoB - 2.8.3.5 ko:K01029 ko00072,ko00280,ko00650,map00072,map00280,map00650 - R00410 RC00014 ko00000,ko00001,ko01000 - - - CoA_trans k59_798584_1 1121918.ARWE01000001_gene1228 2.95e-29 126.0 COG3857@1|root,COG3857@2|Bacteria,1Q1TF@1224|Proteobacteria,43EZ0@68525|delta/epsilon subdivisions,2X1XI@28221|Deltaproteobacteria,43S26@69541|Desulfuromonadales 28221|Deltaproteobacteria L PD-(D/E)XK nuclease superfamily - - - - - - - - - - - - PDDEXK_1 k59_1758390_1 1121921.KB898709_gene234 6.44e-108 335.0 COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,1RMZ8@1236|Gammaproteobacteria,2PMTX@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria I 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain yfcX - 1.1.1.35,4.2.1.17,5.1.2.3 ko:K01782 ko00071,ko00280,ko00281,ko00310,ko00362,ko00380,ko00410,ko00640,ko00650,ko00903,ko00930,ko01040,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00362,map00380,map00410,map00640,map00650,map00903,map00930,map01040,map01100,map01110,map01120,map01130,map01200,map01212 M00032,M00087 R01975,R03026,R03045,R03276,R04137,R04170,R04203,R04204,R04224,R04737,R04738,R04739,R04740,R04741,R04744,R04745,R04746,R04748,R04749,R05066,R05305,R06411,R06412,R06941,R06942,R07935,R07951,R08093,R08094 RC00029,RC00099,RC00117,RC00241,RC00525,RC00831,RC00834,RC00896,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 - - - 3HCDH,3HCDH_N,ECH_1 k59_1588631_1 469610.HMPREF0189_01443 3.06e-07 57.0 COG1560@1|root,COG1560@2|Bacteria,1MVNI@1224|Proteobacteria,2VICZ@28216|Betaproteobacteria,1KIUQ@119065|unclassified Burkholderiales 28216|Betaproteobacteria M Lipid A biosynthesis acyltransferase htrB1 - 2.3.1.241 ko:K02517 ko00540,ko01100,map00540,map01100 M00060 R05146 RC00037,RC00039 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Lip_A_acyltrans k59_798589_1 1122137.AQXF01000006_gene686 1.08e-72 224.0 COG4786@1|root,COG4786@2|Bacteria,1PZ24@1224|Proteobacteria,2U06G@28211|Alphaproteobacteria 28211|Alphaproteobacteria N Belongs to the flagella basal body rod proteins family flgF - - ko:K02391,ko:K02392 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - Flg_bb_rod,Flg_bbr_C k59_798589_2 1187851.A33M_1052 5.17e-11 61.6 COG4786@1|root,COG4786@2|Bacteria,1MVMA@1224|Proteobacteria,2TRR4@28211|Alphaproteobacteria,3FCX9@34008|Rhodovulum 28211|Alphaproteobacteria N Flagella basal body rod protein flgG - - ko:K02392 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - Flg_bb_rod,Flg_bbr_C k59_1701786_1 1121920.AUAU01000021_gene2509 3.76e-113 337.0 COG0674@1|root,COG0674@2|Bacteria,3Y3NB@57723|Acidobacteria 57723|Acidobacteria C Pyruvate:ferredoxin oxidoreductase core domain II - - 1.2.7.7 ko:K00186 ko00280,ko01100,map00280,map01100 - R07160,R08566,R08567 RC00004,RC02833,RC02856 br01601,ko00000,ko00001,ko01000 - - - PFOR_II,POR_N k59_402557_1 1144275.COCOR_01571 2.72e-23 103.0 COG0477@1|root,COG2814@2|Bacteria,1PSYA@1224|Proteobacteria,42P2S@68525|delta/epsilon subdivisions,2WM90@28221|Deltaproteobacteria,2YUIC@29|Myxococcales 28221|Deltaproteobacteria EGP Major facilitator - - - ko:K08218 ko01501,map01501 M00628 - - ko00000,ko00001,ko00002,ko02000 2.A.1.25 - - Acatn,MFS_1 k59_402557_2 1122139.KB907864_gene2120 1.57e-15 77.0 COG1192@1|root,COG1192@2|Bacteria,1R62T@1224|Proteobacteria,1S58J@1236|Gammaproteobacteria,1XK8C@135619|Oceanospirillales 135619|Oceanospirillales D COG1192 ATPases involved in chromosome partitioning - - - - - - - - - - - - AAA_31 k59_684898_3 1347368.HG964405_gene5618 2.77e-06 51.2 COG1396@1|root,COG1917@1|root,COG1396@2|Bacteria,COG1917@2|Bacteria,1V22T@1239|Firmicutes,4HFPB@91061|Bacilli,1ZRJV@1386|Bacillus 91061|Bacilli K Cupin domain - - - - - - - - - - - - Cupin_2,HTH_3 k59_515101_1 1226994.AMZB01000124_gene3019 8.2e-70 234.0 COG1391@1|root,COG1391@2|Bacteria,1MU4I@1224|Proteobacteria,1RP9N@1236|Gammaproteobacteria,1YEJW@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria H Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell glnE GO:0000166,GO:0000287,GO:0000820,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006521,GO:0006541,GO:0006542,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0008882,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0010565,GO:0016053,GO:0016740,GO:0016772,GO:0016779,GO:0017076,GO:0019222,GO:0019752,GO:0030554,GO:0031323,GO:0032553,GO:0032555,GO:0032559,GO:0033238,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046872,GO:0050789,GO:0050794,GO:0051171,GO:0062012,GO:0065007,GO:0070566,GO:0071704,GO:0080090,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.7.42,2.7.7.89 ko:K00982 - - - - ko00000,ko01000 - - - GlnD_UR_UTase,GlnE k59_1136883_1 207954.MED92_03068 4.71e-14 72.4 COG3528@1|root,COG3528@2|Bacteria,1R601@1224|Proteobacteria,1S150@1236|Gammaproteobacteria,1XJ22@135619|Oceanospirillales 135619|Oceanospirillales S Uncharacterized protein conserved in bacteria (DUF2219) - - - - - - - - - - - - DUF2219 k59_1758409_1 502025.Hoch_2050 5.29e-89 276.0 COG2308@1|root,COG2308@2|Bacteria,1MUAD@1224|Proteobacteria,42MA8@68525|delta/epsilon subdivisions,2WIXR@28221|Deltaproteobacteria,2YUA9@29|Myxococcales 28221|Deltaproteobacteria S Circularly permuted ATP-grasp type 2 - - - - - - - - - - - - CP_ATPgrasp_2 k59_1758409_2 502025.Hoch_2049 2.38e-05 45.4 COG2307@1|root,COG2307@2|Bacteria,1MVZK@1224|Proteobacteria,42PS4@68525|delta/epsilon subdivisions,2WM4V@28221|Deltaproteobacteria,2YUI4@29|Myxococcales 28221|Deltaproteobacteria S A predicted alpha-helical domain with a conserved ER motif. - - - - - - - - - - - - Alpha-E k59_64239_1 1033837.WANG_0449 2.82e-06 51.2 COG0484@1|root,COG0484@2|Bacteria,1TP00@1239|Firmicutes,4H9KA@91061|Bacilli,3F490@33958|Lactobacillaceae 91061|Bacilli O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins dnaJ - - ko:K03686 - - - - ko00000,ko03029,ko03110 - - - DnaJ,DnaJ_C,DnaJ_CXXCXGXG k59_1250028_1 398767.Glov_0469 1.22e-81 258.0 COG1530@1|root,COG1530@2|Bacteria,1MV65@1224|Proteobacteria,42M5E@68525|delta/epsilon subdivisions,2WIV6@28221|Deltaproteobacteria 28221|Deltaproteobacteria J ribonuclease Rne Rng family cafA - 3.1.26.12 ko:K08300,ko:K08301 ko03018,map03018 M00394 - - ko00000,ko00001,ko00002,ko01000,ko03009,ko03019 - - - RNase_E_G,S1 k59_1250031_1 1123487.KB892834_gene2755 3.1e-23 94.4 COG3749@1|root,COG3749@2|Bacteria,1RJR9@1224|Proteobacteria,2VSQB@28216|Betaproteobacteria,2KWPT@206389|Rhodocyclales 206389|Rhodocyclales S Bacterial protein of unknown function (DUF934) - - - - - - - - - - - - DUF934 k59_290171_1 886293.Sinac_5856 2.8e-22 101.0 COG0366@1|root,COG3281@1|root,COG0366@2|Bacteria,COG3281@2|Bacteria,2IXJN@203682|Planctomycetes 203682|Planctomycetes G alpha amylase catalytic - - 3.2.1.1,3.2.1.10,5.4.99.16 ko:K01182,ko:K05343 ko00052,ko00500,ko01100,map00052,map00500,map01100 - R00801,R01557,R01718,R01791,R02108,R02112,R06199,R11262 RC00028,RC00059,RC00077,RC00451,RC01816 ko00000,ko00001,ko01000 - GH13 - Alpha-amylase,DUF3459,Malt_amylase_C k59_402611_1 1122137.AQXF01000003_gene2245 5.41e-56 194.0 COG0145@1|root,COG0146@1|root,COG0145@2|Bacteria,COG0146@2|Bacteria,1MU2Y@1224|Proteobacteria,2TQZ6@28211|Alphaproteobacteria 28211|Alphaproteobacteria EQ N-methylhydantoinase A acetone carboxylase, beta subunit oplA - 3.5.2.9 ko:K01469 ko00480,map00480 - R00251 RC00553 ko00000,ko00001,ko01000 - - - Hydant_A_N,Hydantoinase_A,Hydantoinase_B k59_911214_1 436308.Nmar_0690 5.55e-135 387.0 COG2519@1|root,arCOG00978@2157|Archaea,41SEF@651137|Thaumarchaeota 651137|Thaumarchaeota Q tRNA methyltransferase complex GCD14 subunit - - 2.1.1.219,2.1.1.220 ko:K07442 - - - - ko00000,ko01000,ko03016 - - - GCD14 k59_515128_1 1031711.RSPO_c00965 9.86e-85 263.0 COG0538@1|root,COG0538@2|Bacteria,1MW3J@1224|Proteobacteria,2VHVD@28216|Betaproteobacteria,1K0EF@119060|Burkholderiaceae 28216|Betaproteobacteria C Isocitrate dehydrogenase icd GO:0003674,GO:0003824,GO:0003862,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.42 ko:K00031 ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146 M00009,M00010,M00173,M00740 R00267,R00268,R01899 RC00001,RC00084,RC00114,RC00626,RC02801 br01601,ko00000,ko00001,ko00002,ko01000 - - - Iso_dh k59_1136913_3 314275.MADE_000001022515 4.17e-07 52.0 COG0749@1|root,COG0749@2|Bacteria,1MWX7@1224|Proteobacteria,1S0Q1@1236|Gammaproteobacteria 1236|Gammaproteobacteria L ORF located using Glimmer RBSfinder - - 2.7.7.7 ko:K02334 - - - - ko00000,ko01000 - - - DNA_pol_A,DNA_pol_A_exo1 k59_1758440_1 498211.CJA_2933 4.37e-62 207.0 COG0770@1|root,COG0770@2|Bacteria,1QTSF@1224|Proteobacteria,1RMGD@1236|Gammaproteobacteria,1FG8E@10|Cellvibrio 1236|Gammaproteobacteria M Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein murF GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008766,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0030203,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0047480,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 6.3.2.10 ko:K01929 ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502 - R04573,R04617 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - iB21_1397.B21_00086,iEC042_1314.EC042_0087,iEC55989_1330.EC55989_0082,iECBD_1354.ECBD_3531,iECB_1328.ECB_00087,iECD_1391.ECD_00087,iECIAI1_1343.ECIAI1_0085,iECO103_1326.ECO103_0088,iECO111_1330.ECO111_0089,iECO26_1355.ECO26_0089,iECSE_1348.ECSE_0088,iECW_1372.ECW_m0085,iEKO11_1354.EKO11_3828,iEcE24377_1341.EcE24377A_0088,iEcHS_1320.EcHS_A0092,iEcolC_1368.EcolC_3571,iSBO_1134.SBO_0074,iSSON_1240.SSON_0094,iSbBS512_1146.SbBS512_E0079,iUMNK88_1353.UMNK88_86,iWFL_1372.ECW_m0085,iYL1228.KPN_00090 Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_346690_1 1122137.AQXF01000002_gene283 3.94e-75 233.0 COG2130@1|root,COG2130@2|Bacteria,1MUC2@1224|Proteobacteria,2TQYM@28211|Alphaproteobacteria 28211|Alphaproteobacteria L NADP-dependent oxidoreductase - - - ko:K07119 - - - - ko00000 - - - ADH_N_2,ADH_zinc_N k59_346690_2 1122137.AQXF01000002_gene282 3.31e-101 293.0 COG0102@1|root,COG0102@2|Bacteria,1RA11@1224|Proteobacteria,2U5FM@28211|Alphaproteobacteria 28211|Alphaproteobacteria J This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly rplM GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02871 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L13 k59_346690_3 1122137.AQXF01000002_gene281 6.8e-95 278.0 COG0103@1|root,COG0103@2|Bacteria,1RD4A@1224|Proteobacteria,2U5B5@28211|Alphaproteobacteria 28211|Alphaproteobacteria J Belongs to the universal ribosomal protein uS9 family rpsI GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02996 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S9 k59_1136917_1 570967.JMLV01000014_gene2071 1.12e-108 324.0 COG1653@1|root,COG1653@2|Bacteria,1P20V@1224|Proteobacteria,2TVPW@28211|Alphaproteobacteria 28211|Alphaproteobacteria G ABC transporter - - - - - - - - - - - - SBP_bac_8 k59_741779_1 1163617.SCD_n00802 2.75e-85 261.0 COG1856@1|root,COG1856@2|Bacteria,1R6PW@1224|Proteobacteria 1224|Proteobacteria S SMART Elongator protein 3 MiaB NifB - - - ko:K09711 - - - - ko00000 - - - Radical_SAM k59_1306904_1 1122194.AUHU01000007_gene223 2.42e-40 140.0 COG2854@1|root,COG2854@2|Bacteria,1NKFA@1224|Proteobacteria,1SABB@1236|Gammaproteobacteria,467R8@72275|Alteromonadaceae 1236|Gammaproteobacteria Q COG2854 ABC-type transport system involved in resistance to organic solvents, auxiliary component ttg2D - - ko:K07323 ko02010,map02010 M00210 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27.3 - - MlaC k59_1306904_2 1121921.KB898706_gene2753 2.56e-18 78.6 COG5007@1|root,COG5007@2|Bacteria,1MZCZ@1224|Proteobacteria,1SWYQ@1236|Gammaproteobacteria,2PNX5@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria K BolA-like protein - - - - - - - - - - - - BolA k59_290189_1 204669.Acid345_2658 1.16e-84 269.0 COG2303@1|root,COG2303@2|Bacteria,3Y41Y@57723|Acidobacteria,2JIXF@204432|Acidobacteriia 204432|Acidobacteriia E GMC oxidoreductase - - - - - - - - - - - - GMC_oxred_C,GMC_oxred_N k59_1532766_2 391600.ABRU01000040_gene1777 5.26e-69 212.0 COG3108@1|root,COG3108@2|Bacteria,1RICX@1224|Proteobacteria,2UDAG@28211|Alphaproteobacteria,2KJH3@204458|Caulobacterales 204458|Caulobacterales S D-alanyl-D-alanine carboxypeptidase - - - - - - - - - - - - Peptidase_M15_4 k59_1532766_5 218851.Aquca_066_00014.1 3.93e-15 87.8 COG0141@1|root,KOG1002@2759|Eukaryota,37QET@33090|Viridiplantae,3G89C@35493|Streptophyta 35493|Streptophyta L SNF2 domain-containing protein helicase domain-containing protein RING finger domain-containing protein - GO:0000109,GO:0000166,GO:0000720,GO:0003674,GO:0003676,GO:0003677,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0004842,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0006139,GO:0006259,GO:0006281,GO:0006289,GO:0006290,GO:0006464,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0008270,GO:0009987,GO:0016043,GO:0016462,GO:0016567,GO:0016740,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0019787,GO:0030554,GO:0032392,GO:0032446,GO:0032508,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033554,GO:0034641,GO:0035639,GO:0036094,GO:0036211,GO:0042623,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044422,GO:0044424,GO:0044428,GO:0044446,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0050896,GO:0051276,GO:0051716,GO:0061630,GO:0061659,GO:0070035,GO:0070647,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0097367,GO:0140096,GO:0140097,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1990391 - ko:K08066,ko:K15083 ko04612,ko05152,map04612,map05152 - - - ko00000,ko00001,ko03000,ko03400 - - - Helicase_C,SNF2_N,zf-C3HC4,zf-C3HC4_2,zf-C3HC4_3,zf-RING_UBOX k59_1532766_12 1548905.A0A0A1IUL8_9CAUD 3.39e-71 233.0 4QBA2@10239|Viruses,4QPPI@28883|Caudovirales,4QM0B@10699|Siphoviridae 10699|Siphoviridae S Thymidylate synthase - GO:0003674,GO:0003824,GO:0004799,GO:0008150,GO:0008152,GO:0008168,GO:0016740,GO:0016741,GO:0032259,GO:0042083 - - - - - - - - - - - k59_182612_2 1096930.L284_23160 2.57e-22 86.7 2FC5G@1|root,31H26@2|Bacteria,1NK4H@1224|Proteobacteria,2UM33@28211|Alphaproteobacteria,2KDQK@204457|Sphingomonadales 204457|Sphingomonadales - - - - - - - - - - - - - - - k59_1031763_2 314285.KT71_11159 3.26e-49 172.0 COG0556@1|root,COG0556@2|Bacteria,1MUFK@1224|Proteobacteria,1RN6Z@1236|Gammaproteobacteria,1J517@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage uvrB GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009314,GO:0009380,GO:0009628,GO:0032991,GO:0042802,GO:0044424,GO:0044464,GO:0050896,GO:1902494,GO:1905347,GO:1905348,GO:1990391 - ko:K03702 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - Helicase_C,ResIII,UVR,UvrB k59_1708666_1 1229909.NSED_03485 2.8e-107 316.0 COG0492@1|root,arCOG01296@2157|Archaea,41S97@651137|Thaumarchaeota 651137|Thaumarchaeota O Pyridine nucleotide-disulphide oxidoreductase - - 1.8.1.9 ko:K00384 ko00450,map00450 - R02016,R03596,R09372 RC00013,RC02518,RC02873 ko00000,ko00001,ko01000 - - - Pyr_redox_2 k59_748140_1 1278309.KB907103_gene1128 5.2e-25 102.0 COG0136@1|root,COG0136@2|Bacteria,1MUHG@1224|Proteobacteria,1RMN3@1236|Gammaproteobacteria,1XHYW@135619|Oceanospirillales 135619|Oceanospirillales E Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate asd - 1.2.1.11 ko:K00133 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00017,M00018,M00033,M00525,M00526,M00527 R02291 RC00684 ko00000,ko00001,ko00002,ko01000 - - - Semialdhyde_dh,Semialdhyde_dhC k59_748140_2 526225.Gobs_0470 1.69e-24 100.0 COG1011@1|root,COG1011@2|Bacteria,2IN1K@201174|Actinobacteria,4EWCK@85013|Frankiales 201174|Actinobacteria S Haloacid dehalogenase-like hydrolase - - - ko:K07025 - - - - ko00000 - - - HAD_2,Hydrolase k59_183833_1 159087.Daro_1752 4.08e-14 74.3 COG1044@1|root,COG1044@2|Bacteria,1MUX6@1224|Proteobacteria,2VHJR@28216|Betaproteobacteria,2KVNR@206389|Rhodocyclales 206389|Rhodocyclales M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell lpxD - 2.3.1.191 ko:K02536 ko00540,ko01100,map00540,map01100 M00060 R04550 RC00039,RC00166 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Hexapep,Hexapep_2,LpxD k59_183833_2 859657.RPSI07_1949 3.5e-26 103.0 COG2825@1|root,COG2825@2|Bacteria,1RD8X@1224|Proteobacteria,2VRZI@28216|Betaproteobacteria,1K13G@119060|Burkholderiaceae 28216|Betaproteobacteria M Belongs to the skp family ompH - - ko:K06142 - - - - ko00000 - - - OmpH k59_521966_1 498761.HM1_1897 7.91e-52 176.0 COG1187@1|root,COG1187@2|Bacteria,1TP68@1239|Firmicutes,248UG@186801|Clostridia 186801|Clostridia J Belongs to the pseudouridine synthase RsuA family rluB - 5.4.99.19,5.4.99.22 ko:K06178,ko:K06183 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2,S4 k59_127506_1 1122137.AQXF01000002_gene625 1.27e-15 75.9 COG0154@1|root,COG0154@2|Bacteria,1MUVQ@1224|Proteobacteria,2TRFY@28211|Alphaproteobacteria 28211|Alphaproteobacteria J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) gatA - 6.3.5.6,6.3.5.7 ko:K02433 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - Amidase k59_127506_2 439375.Oant_3662 3.1e-27 102.0 COG0721@1|root,COG0721@2|Bacteria,1MZQP@1224|Proteobacteria,2UBSZ@28211|Alphaproteobacteria,1J35F@118882|Brucellaceae 28211|Alphaproteobacteria J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) gatC - 6.3.5.6,6.3.5.7 ko:K02435 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - Glu-tRNAGln k59_127506_3 1122137.AQXF01000002_gene628 7.91e-41 142.0 COG0454@1|root,COG0456@2|Bacteria,1R100@1224|Proteobacteria,2UMME@28211|Alphaproteobacteria 28211|Alphaproteobacteria K Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_1 k59_239752_1 330214.NIDE1418 3.85e-16 78.6 COG1386@1|root,COG1386@2|Bacteria,3J15Z@40117|Nitrospirae 40117|Nitrospirae D Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves scpB - - ko:K06024 - - - - ko00000,ko03036 - - - SMC_ScpB k59_1314017_1 446470.Snas_0537 1.96e-33 132.0 COG3055@1|root,COG3055@2|Bacteria 2|Bacteria G Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses - - - - - - - - - - - - Big_2,Kelch_1,Kelch_3,Kelch_6 k59_1370547_2 1122137.AQXF01000009_gene12 1.02e-144 445.0 COG0086@1|root,COG0086@2|Bacteria,1MU3M@1224|Proteobacteria,2TRHV@28211|Alphaproteobacteria 28211|Alphaproteobacteria K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoC GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234 2.7.7.6 ko:K03046,ko:K13797 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5 k59_465884_1 1123037.AUDE01000021_gene2201 2.23e-57 201.0 COG1629@1|root,COG1629@2|Bacteria,4PKRK@976|Bacteroidetes,1IJDQ@117743|Flavobacteriia 976|Bacteroidetes P receptor - - - - - - - - - - - - CarbopepD_reg_2,CarboxypepD_reg,Plug,TonB_dep_Rec k59_353661_1 1229909.NSED_01175 3.08e-30 111.0 COG1581@1|root,arCOG01753@2157|Archaea,41SQ4@651137|Thaumarchaeota 651137|Thaumarchaeota K Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes - - - ko:K03622 - - - - ko00000 - - - Alba k59_692006_1 1108849.XP_002559268.1 7.46e-50 163.0 COG0757@1|root,2S1A9@2759|Eukaryota,3A2KS@33154|Opisthokonta,3P36E@4751|Fungi,3QV0F@4890|Ascomycota,20IA1@147545|Eurotiomycetes,3SASU@5042|Eurotiales 4751|Fungi H Is involved in the catabolism of quinate. Allows the utilization of quinate as carbon source via the beta-ketoadipate pathway qutE GO:0003674,GO:0003824,GO:0003855,GO:0006082,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016054,GO:0016829,GO:0016835,GO:0016836,GO:0019630,GO:0019631,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0071704,GO:0072329,GO:1901360,GO:1901361,GO:1901575,GO:1901615,GO:1901616 4.2.1.10 ko:K03786 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R03084 RC00848 ko00000,ko00001,ko00002,ko01000 - - - DHquinase_II k59_409540_1 1123269.NX02_07430 3.3e-40 146.0 COG1940@1|root,COG1940@2|Bacteria,1MVGQ@1224|Proteobacteria,2TRFX@28211|Alphaproteobacteria,2K0K3@204457|Sphingomonadales 204457|Sphingomonadales GK ROK family - - - - - - - - - - - - HTH_24,ROK k59_1031814_1 1232410.KI421415_gene3058 1.08e-80 251.0 COG3424@1|root,COG3424@2|Bacteria,1MUDX@1224|Proteobacteria,42UCQ@68525|delta/epsilon subdivisions,2WQ17@28221|Deltaproteobacteria,43V66@69541|Desulfuromonadales 28221|Deltaproteobacteria Q Chalcone and stilbene synthases, C-terminal domain - - - - - - - - - - - - Chal_sti_synt_C,Chal_sti_synt_N,FAE1_CUT1_RppA k59_1314047_1 179408.Osc7112_2732 1.93e-76 246.0 COG1249@1|root,COG1249@2|Bacteria,1G198@1117|Cyanobacteria,1H7PH@1150|Oscillatoriales 1117|Cyanobacteria C Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase merA - - - - - - - - - - - Pyr_redox_2,Pyr_redox_dim,SNARE_assoc k59_353672_1 1229909.NSED_06400 5.52e-112 334.0 COG3794@1|root,arCOG08764@1|root,arCOG02926@2157|Archaea,arCOG08764@2157|Archaea 2157|Archaea C PFAM blue (type 1) copper domain protein - - - - - - - - - - - - Copper-bind k59_635502_2 388051.AUFE01000030_gene5130 1.5e-09 65.1 COG2010@1|root,COG2010@2|Bacteria,1MV6D@1224|Proteobacteria,2VMKN@28216|Betaproteobacteria,1KGP2@119060|Burkholderiaceae 28216|Betaproteobacteria C Cytochrome c - - - - - - - - - - - - Cytochrom_C,Cytochrome_CBB3 k59_239801_1 511.JT27_08260 1.32e-15 80.5 COG0352@1|root,COG0494@1|root,COG0352@2|Bacteria,COG0494@2|Bacteria,1RCZM@1224|Proteobacteria,2VHTP@28216|Betaproteobacteria,3T2CP@506|Alcaligenaceae 28216|Betaproteobacteria HL Belongs to the Nudix hydrolase family mutT - 3.6.1.55 ko:K03574 - - - - ko00000,ko01000,ko03400 - - - NUDIX,TMP-TENI k59_692020_1 1234595.C725_1201 2.25e-72 233.0 COG3182@1|root,COG3182@2|Bacteria,1MVET@1224|Proteobacteria,2TVHW@28211|Alphaproteobacteria 28211|Alphaproteobacteria IQ iron-regulated membrane protein - - - - - - - - - - - - PepSY_TM k59_578996_1 411154.GFO_2840 7.78e-60 185.0 COG0051@1|root,COG0051@2|Bacteria,4NQ65@976|Bacteroidetes,1I2VK@117743|Flavobacteriia 976|Bacteroidetes J Involved in the binding of tRNA to the ribosomes rpsJ GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02946 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S10 k59_1652811_1 525373.HMPREF0766_11620 1.21e-160 473.0 COG2993@1|root,COG3278@1|root,COG2993@2|Bacteria,COG3278@2|Bacteria,4NEGM@976|Bacteroidetes,1IP6D@117747|Sphingobacteriia 976|Bacteroidetes C Belongs to the heme-copper respiratory oxidase family ccoN - 1.9.3.1 ko:K15862 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00156 - - ko00000,ko00001,ko00002,ko01000 3.D.4.3 - - COX1,FixO k59_127548_1 886377.Murru_0194 9.34e-30 115.0 COG3055@1|root,COG3055@2|Bacteria,4NG50@976|Bacteroidetes,1HY2Q@117743|Flavobacteriia 976|Bacteroidetes DZ Pfam Kelch nanM - - - - - - - - - - - Kelch_1,Kelch_3,Kelch_4,Kelch_6 k59_353688_2 1229909.NSED_04950 5.73e-79 246.0 COG1503@1|root,arCOG01742@2157|Archaea,41SEK@651137|Thaumarchaeota 651137|Thaumarchaeota J Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA prf1 - - ko:K03265 ko03015,map03015 - - - ko00000,ko00001,ko03012,ko03019 - - - eRF1_1,eRF1_2,eRF1_3 k59_1031862_2 1122137.AQXF01000006_gene894 5.41e-40 137.0 COG0024@1|root,COG0024@2|Bacteria,1MU99@1224|Proteobacteria,2TQTH@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Methionine aminopeptidase map - 3.4.11.18 ko:K01265 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M24 k59_465906_1 396588.Tgr7_1360 7.29e-56 182.0 COG0664@1|root,COG0664@2|Bacteria,1R6BV@1224|Proteobacteria,1S69P@1236|Gammaproteobacteria,1WX67@135613|Chromatiales 135613|Chromatiales K cyclic nucleotide-binding - - - ko:K01420 - - - - ko00000,ko03000 - - - HTH_Crp_2,cNMP_binding k59_1765377_1 1123013.AUIC01000004_gene1910 9e-08 54.7 COG0356@1|root,COG0356@2|Bacteria,2H3PR@201174|Actinobacteria,4FM5U@85023|Microbacteriaceae 201174|Actinobacteria C it plays a direct role in the translocation of protons across the membrane atpB - - ko:K02108 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko03110 3.A.2.1 - - ATP-synt_A k59_1765377_2 1313172.YM304_10600 4.6e-22 88.2 COG0636@1|root,COG0636@2|Bacteria,2GQI6@201174|Actinobacteria,4CNBJ@84992|Acidimicrobiia 84992|Acidimicrobiia C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation atpE - - ko:K02110 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt_C k59_1765377_3 1283287.KB822580_gene1701 1.34e-06 53.1 COG0711@1|root,COG0711@2|Bacteria,2GJS4@201174|Actinobacteria,4DUHE@85009|Propionibacteriales 201174|Actinobacteria C ATP synthase B/B' CF(0) atpF - - ko:K02109 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt_B k59_14558_1 1040989.AWZU01000028_gene3006 7.97e-15 73.6 COG3573@1|root,COG3573@2|Bacteria,1MVX8@1224|Proteobacteria,2TVKJ@28211|Alphaproteobacteria,3JSJV@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S FAD binding domain MA20_22130 - - ko:K07077 - - - - ko00000 - - - FAD_binding_2 k59_14558_2 944435.AXAJ01000005_gene3489 2.51e-81 250.0 COG1028@1|root,COG1028@2|Bacteria,1MVYJ@1224|Proteobacteria,2VH22@28216|Betaproteobacteria,1K4AS@119060|Burkholderiaceae 28216|Betaproteobacteria IQ Involved in the nonphosphorylative, ketogenic oxidation of glucose and oxidizes gluconate to 5-ketogluconate gno1 - 1.1.1.69 ko:K00046 - - - - ko00000,ko01000 - - - adh_short,adh_short_C2 k59_918023_1 1317118.ATO8_20409 4.4e-50 169.0 COG1295@1|root,COG1295@2|Bacteria,1MXQA@1224|Proteobacteria,2TSFP@28211|Alphaproteobacteria,4KK7N@93682|Roseivivax 28211|Alphaproteobacteria S Ribonuclease BN - - - ko:K07058 - - - - ko00000 - - - Virul_fac_BrkB k59_918023_3 323848.Nmul_A1923 6.19e-33 119.0 COG1873@1|root,COG1873@2|Bacteria,1QTWZ@1224|Proteobacteria,2VT3J@28216|Betaproteobacteria,3730X@32003|Nitrosomonadales 28216|Betaproteobacteria S PRC-barrel domain - - - - - - - - - - - - PRC k59_297240_1 1415780.JPOG01000001_gene751 7.82e-12 65.5 COG2834@1|root,COG2834@2|Bacteria,1MXW0@1224|Proteobacteria,1RS0K@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Outer membrane lipoprotein-sorting protein VPA0557 - - - - - - - - - - - LolA_like k59_183912_1 998088.B565_0080 4.92e-70 232.0 COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,1RNJI@1236|Gammaproteobacteria,1Y43B@135624|Aeromonadales 135624|Aeromonadales L DNA helicase uvrD - 3.6.4.12 ko:K03657 ko03420,ko03430,map03420,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - UvrD-helicase,UvrD_C k59_127574_1 1411123.JQNH01000001_gene2713 8.63e-90 284.0 COG4666@1|root,COG4666@2|Bacteria,1MUNB@1224|Proteobacteria,2TQY9@28211|Alphaproteobacteria 28211|Alphaproteobacteria S transport system fused permease components - - - - - - - - - - - - DUF3394,DctM k59_409576_1 1122137.AQXF01000001_gene3098 5.33e-212 622.0 COG1520@1|root,COG1520@2|Bacteria,1P31B@1224|Proteobacteria,2U4EC@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane - - - - - - - - - - - - - k59_1370602_2 1157490.EL26_11700 1.18e-60 203.0 COG1207@1|root,COG1207@2|Bacteria,1TP88@1239|Firmicutes,4H9V5@91061|Bacilli,278XE@186823|Alicyclobacillaceae 91061|Bacilli M Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain glmU - 2.3.1.157,2.7.7.23 ko:K04042 ko00520,ko01100,ko01130,map00520,map01100,map01130 M00362 R00416,R05332 RC00002,RC00004,RC00166 ko00000,ko00001,ko00002,ko01000 - - - Hexapep,Hexapep_2,NTP_transf_3,NTP_transferase k59_239866_1 1206720.BAFQ01000272_gene5717 5.54e-18 85.5 COG1733@1|root,COG1733@2|Bacteria,2GMK5@201174|Actinobacteria,4FYMD@85025|Nocardiaceae 201174|Actinobacteria K HxlR-like helix-turn-helix - - - - - - - - - - - - HxlR k59_1143806_1 1266909.AUAG01000008_gene1967 2.17e-32 127.0 COG0860@1|root,COG0860@2|Bacteria,1MUQK@1224|Proteobacteria,1RMP1@1236|Gammaproteobacteria,1WX8Q@135613|Chromatiales 135613|Chromatiales M Cell wall hydrolase autolysin - - 3.5.1.28 ko:K01448 ko01503,map01503 M00727 R04112 RC00064,RC00141 ko00000,ko00001,ko00002,ko01000,ko01011,ko03036 - - - AMIN,Amidase_3,LysM k59_1256918_1 477184.KYC_10643 3.52e-05 45.8 COG0180@1|root,COG0180@2|Bacteria,1MV4T@1224|Proteobacteria,2VIEY@28216|Betaproteobacteria,3T1CX@506|Alcaligenaceae 28216|Betaproteobacteria J Catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA trpS GO:0003674,GO:0003824,GO:0004812,GO:0004830,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006436,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.2 ko:K01867 ko00970,map00970 M00359,M00360 R03664 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DUF1508,tRNA-synt_1b k59_1256918_2 396588.Tgr7_2571 9.06e-09 57.8 2EPXK@1|root,316W1@2|Bacteria,1NIJ5@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_1256918_3 1328313.DS2_16034 1.02e-39 134.0 COG2119@1|root,COG2119@2|Bacteria,1N85A@1224|Proteobacteria,1SAAX@1236|Gammaproteobacteria,4690H@72275|Alteromonadaceae 1236|Gammaproteobacteria S Uncharacterized protein family UPF0016 - - - - - - - - - - - - UPF0016 k59_297256_1 1026882.MAMP_00529 1.02e-91 275.0 COG2199@1|root,COG2199@2|Bacteria,1RJGY@1224|Proteobacteria,1SBRV@1236|Gammaproteobacteria 1236|Gammaproteobacteria T PAS fold - - - - - - - - - - - - PAS,PAS_3 k59_635561_1 1123057.P872_09010 8.22e-41 145.0 COG2801@1|root,COG2801@2|Bacteria,4NF3Q@976|Bacteroidetes,47NB8@768503|Cytophagia 976|Bacteroidetes L Integrase core domain - - - ko:K07497 - - - - ko00000 - - - HTH_21,HTH_Tnp_1,rve,rve_3 k59_409602_2 498211.CJA_3426 1.66e-31 123.0 COG0677@1|root,COG0677@2|Bacteria,1MUC6@1224|Proteobacteria,1RMX0@1236|Gammaproteobacteria,1FGVH@10|Cellvibrio 1236|Gammaproteobacteria M UDP binding domain wecC - - ko:K02474 ko00520,map00520 - R06894 RC00291 ko00000,ko00001,ko01000,ko01005 - - - UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N k59_297257_1 414684.RC1_0905 9.34e-170 483.0 COG3825@1|root,COG3825@2|Bacteria,1MUAJ@1224|Proteobacteria,2TS5P@28211|Alphaproteobacteria,2JQTH@204441|Rhodospirillales 204441|Rhodospirillales S protein conserved in bacteria - - - ko:K09989 - - - - ko00000 - - - VWA_CoxE k59_1595907_1 1242864.D187_003418 1.43e-15 75.5 COG1219@1|root,COG1219@2|Bacteria,1MVQK@1224|Proteobacteria,42MWJ@68525|delta/epsilon subdivisions,2WJ8Q@28221|Deltaproteobacteria,2YUHC@29|Myxococcales 28221|Deltaproteobacteria O ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP clpX GO:0000166,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005524,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030163,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0044238,GO:0051301,GO:0070011,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575 - ko:K03544 ko04112,map04112 - - - ko00000,ko00001,ko03110 - - - AAA_2,ClpB_D2-small,zf-C4_ClpX k59_1595907_2 696747.NIES39_D02590 7.09e-90 269.0 COG0740@1|root,COG0740@2|Bacteria,1G1TB@1117|Cyanobacteria,1H7BZ@1150|Oscillatoriales 1117|Cyanobacteria OU Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins clpP1 - 3.4.21.92 ko:K01358 ko04112,ko04212,map04112,map04212 - - - ko00000,ko00001,ko01000,ko01002 - - - CLP_protease k59_1031912_2 555088.DealDRAFT_1137 2.57e-05 47.0 COG0507@1|root,COG0507@2|Bacteria,1TPZH@1239|Firmicutes,247R7@186801|Clostridia,42KG3@68298|Syntrophomonadaceae 186801|Clostridia L DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity recD2 - 3.1.11.5 ko:K03581 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - AAA_30,HHH_4,HHH_5,UvrD_C_2 k59_1256925_1 1415778.JQMM01000001_gene671 1.32e-94 291.0 COG0147@1|root,COG0147@2|Bacteria,1MVBJ@1224|Proteobacteria,1RMSE@1236|Gammaproteobacteria,1J5AP@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia trpE - 4.1.3.27 ko:K01657 ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025 M00023 R00985,R00986 RC00010,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 - - iJN746.PP_0417 Anth_synt_I_N,Chorismate_bind k59_1256925_2 1415778.JQMM01000001_gene670 1.69e-128 368.0 COG0036@1|root,COG0036@2|Bacteria,1MUZM@1224|Proteobacteria,1RN3K@1236|Gammaproteobacteria,1J4M6@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria G Belongs to the ribulose-phosphate 3-epimerase family rpe GO:0003674,GO:0003824,GO:0004750,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008198,GO:0009052,GO:0009056,GO:0009117,GO:0009987,GO:0016052,GO:0016853,GO:0016854,GO:0016857,GO:0019321,GO:0019323,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046483,GO:0046496,GO:0046872,GO:0046914,GO:0051156,GO:0051186,GO:0055086,GO:0071704,GO:0072524,GO:1901135,GO:1901360,GO:1901564,GO:1901575 5.1.3.1 ko:K01783 ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007 R01529 RC00540 ko00000,ko00001,ko00002,ko01000 - - iPC815.YPO0155,iYL1228.KPN_03757 Ribul_P_3_epim k59_127602_1 1122137.AQXF01000002_gene519 1.41e-05 52.8 COG0480@1|root,COG0480@2|Bacteria,1MU2W@1224|Proteobacteria,2TYVK@28211|Alphaproteobacteria 28211|Alphaproteobacteria J elongation factor G MA20_05220 - - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2 k59_239906_1 1219035.NT2_01_04390 1.71e-26 102.0 COG5349@1|root,COG5349@2|Bacteria,1N0WU@1224|Proteobacteria,2UCE7@28211|Alphaproteobacteria,2K61Z@204457|Sphingomonadales 204457|Sphingomonadales S Protein of unknown function (DUF983) - - - - - - - - - - - - DUF983 k59_1031915_1 1265502.KB905933_gene2053 1.27e-106 326.0 COG1154@1|root,COG1154@2|Bacteria,1MUSJ@1224|Proteobacteria,2VHXG@28216|Betaproteobacteria,4A9JK@80864|Comamonadaceae 28216|Betaproteobacteria H Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) dxs - 2.2.1.7 ko:K01662 ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130 M00096 R05636 RC00032 ko00000,ko00001,ko00002,ko01000 - - - DXP_synthase_N,Transket_pyr,Transketolase_C k59_1031918_2 1131266.ARWQ01000008_gene338 3.59e-64 198.0 COG0838@1|root,arCOG01557@2157|Archaea,41SMI@651137|Thaumarchaeota 651137|Thaumarchaeota C PFAM NADH-ubiquinone plastoquinone oxidoreductase chain 3 - - 1.6.5.3 ko:K00330 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q4 k59_1370624_1 509190.Cseg_2177 9.59e-29 106.0 COG3761@1|root,COG3761@2|Bacteria,1RHS3@1224|Proteobacteria,2U95G@28211|Alphaproteobacteria,2KGNZ@204458|Caulobacterales 204458|Caulobacterales C NADH ubiquinone oxidoreductase 17.2 kD subunit - - - - - - - - - - - - NDUFA12 k59_1370624_2 1122137.AQXF01000002_gene358 2.23e-65 203.0 COG1463@1|root,COG1463@2|Bacteria,1NCUG@1224|Proteobacteria,2UCHU@28211|Alphaproteobacteria 28211|Alphaproteobacteria Q COG1463 ABC-type transport system involved in resistance to organic solvents periplasmic component mlaD - - ko:K02067 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - MlaD k59_1370624_3 1122137.AQXF01000002_gene357 7.47e-59 186.0 COG4765@1|root,COG4765@2|Bacteria,1RHI7@1224|Proteobacteria,2UBR9@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Protein conserved in bacteria - - - - - - - - - - - - DUF2155 k59_1370624_4 1122613.ATUP01000001_gene238 3.28e-29 110.0 COG2360@1|root,COG2360@2|Bacteria,1R9W8@1224|Proteobacteria,2U59K@28211|Alphaproteobacteria,43XES@69657|Hyphomonadaceae 28211|Alphaproteobacteria O Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine aat GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008914,GO:0016740,GO:0016746,GO:0016755,GO:0044424,GO:0044464,GO:0140096 2.3.2.6 ko:K00684 - - R03813,R11443,R11444 RC00055,RC00064 ko00000,ko01000 - - - Leu_Phe_trans k59_1200681_2 1082933.MEA186_27400 1.62e-32 137.0 COG2124@1|root,COG2837@1|root,COG2124@2|Bacteria,COG2837@2|Bacteria,1MXKF@1224|Proteobacteria,2TTJE@28211|Alphaproteobacteria 28211|Alphaproteobacteria P peroxidase - - - ko:K07223 - - - - ko00000 - - - Dyp_perox,p450 k59_862659_1 382464.ABSI01000010_gene3211 3.26e-61 201.0 COG3250@1|root,COG3250@2|Bacteria,46UEM@74201|Verrucomicrobia 74201|Verrucomicrobia G Beta-galactosidase jelly roll domain - - - - - - - - - - - - BetaGal_dom4_5 k59_297264_1 236097.ADG881_699 8.17e-120 358.0 COG0573@1|root,COG0573@2|Bacteria,1MVKP@1224|Proteobacteria,1RQXJ@1236|Gammaproteobacteria,1XIWP@135619|Oceanospirillales 135619|Oceanospirillales P probably responsible for the translocation of the substrate across the membrane pstC - - ko:K02037 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - BPD_transp_1,DUF3708 k59_918084_1 1278073.MYSTI_03875 2.57e-28 120.0 COG0515@1|root,COG3899@1|root,COG4191@1|root,COG0515@2|Bacteria,COG3899@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,43BKN@68525|delta/epsilon subdivisions,2WJNS@28221|Deltaproteobacteria 28221|Deltaproteobacteria KLT AAA ATPase domain - - - - - - - - - - - - AAA_16,GAF,HATPase_c,HisKA,Pkinase k59_14610_1 1380391.JIAS01000018_gene1079 6.5e-59 190.0 COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,2TQTP@28211|Alphaproteobacteria,2JS2T@204441|Rhodospirillales 204441|Rhodospirillales L Transposase IS116/IS110/IS902 family - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_918088_1 926569.ANT_26910 1.55e-44 169.0 COG0596@1|root,COG0596@2|Bacteria,2G6Y2@200795|Chloroflexi 200795|Chloroflexi I PFAM alpha beta hydrolase fold - - - - - - - - - - - - Abhydrolase_1,Abhydrolase_4 k59_579967_1 247634.GPB2148_3503 2.55e-17 79.0 COG2378@1|root,COG2378@2|Bacteria,1Q19K@1224|Proteobacteria,1RZ1N@1236|Gammaproteobacteria 1236|Gammaproteobacteria K transcriptional regulator - - - - - - - - - - - - WYL k59_579967_2 479434.Sthe_1720 4.99e-37 136.0 COG0427@1|root,COG0427@2|Bacteria,2G60V@200795|Chloroflexi 200795|Chloroflexi C PFAM Acetyl-CoA hydrolase transferase - - 3.1.2.1 ko:K01067 ko00620,map00620 - R00227 RC00004,RC00012 ko00000,ko00001,ko01000 - - - AcetylCoA_hyd_C,AcetylCoA_hydro k59_416355_2 1415778.JQMM01000001_gene1395 7.02e-80 250.0 COG3303@1|root,COG3303@2|Bacteria,1R5JF@1224|Proteobacteria,1S13K@1236|Gammaproteobacteria,1J8YW@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Cytochrome c3 - - - - - - - - - - - - Cytochrom_C552,Cytochrom_c3_2 k59_134319_1 589865.DaAHT2_1540 7.26e-82 253.0 COG0616@1|root,COG0616@2|Bacteria,1MUXE@1224|Proteobacteria,42MNA@68525|delta/epsilon subdivisions,2WK7Z@28221|Deltaproteobacteria,2MIPV@213118|Desulfobacterales 28221|Deltaproteobacteria OU signal peptide peptidase SppA sppA - - ko:K04773 - - - - ko00000,ko01000,ko01002 - - - Peptidase_S49 k59_416370_1 589865.DaAHT2_1100 4.83e-05 45.4 COG0859@1|root,COG0859@2|Bacteria,1MYZA@1224|Proteobacteria,42S0J@68525|delta/epsilon subdivisions,2X5EN@28221|Deltaproteobacteria 28221|Deltaproteobacteria M Glycosyltransferase family 9 (heptosyltransferase) - - - ko:K12982 - - - - ko00000,ko01000,ko01003,ko01005 - GT9 - Glyco_transf_9 k59_416370_2 1121939.L861_12940 1.07e-38 139.0 COG0859@1|root,COG0859@2|Bacteria,1MXA2@1224|Proteobacteria,1RMBF@1236|Gammaproteobacteria,1XHQ9@135619|Oceanospirillales 135619|Oceanospirillales M heptosyltransferase waaF - - ko:K02843 ko00540,ko01100,map00540,map01100 M00080 - - ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT9 - Glyco_transf_9 k59_78775_1 996306.SSUR61_1999 4.4e-05 48.1 COG0845@1|root,COG0845@2|Bacteria,1V5DX@1239|Firmicutes,4HMQM@91061|Bacilli,1WTB4@1307|Streptococcus suis 91061|Bacilli M Barrel-sandwich domain of CusB or HlyD membrane-fusion acrA - - ko:K02005,ko:K13888 - M00709 - - ko00000,ko00002,ko02000 8.A.1 - - Biotin_lipoyl_2,HlyD_3,HlyD_D23 k59_78775_2 283942.IL2304 4.11e-90 295.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,2QEXG@267893|Idiomarinaceae 1236|Gammaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family acrF - - ko:K18138 ko01501,ko01503,map01501,map01503 M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000 2.A.6.2 - - ACR_tran k59_1094038_2 1121373.KB903665_gene3122 1.14e-36 132.0 COG3677@1|root,COG3677@2|Bacteria,4NJC5@976|Bacteroidetes 976|Bacteroidetes L ISXO2-like transposase domain - - - - - - - - - - - - DDE_Tnp_IS1595,Zn_Tnp_IS1595 k59_1547029_1 340177.Cag_0488 1.93e-19 87.4 COG0242@1|root,COG0242@2|Bacteria,1FE2I@1090|Chlorobi 1090|Chlorobi J Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions def - 3.5.1.88 ko:K01462 - - - - ko00000,ko01000 - - - Pep_deformylase k59_1547029_2 768671.ThimaDRAFT_2367 1.02e-45 161.0 COG0223@1|root,COG0223@2|Bacteria,1MU4Q@1224|Proteobacteria,1RP1T@1236|Gammaproteobacteria,1WWQE@135613|Chromatiales 135613|Chromatiales J Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus fmt - 2.1.2.9 ko:K00604 ko00670,ko00970,map00670,map00970 - R03940 RC00026,RC00165 ko00000,ko00001,ko01000 - - - Formyl_trans_C,Formyl_trans_N k59_1603149_1 436308.Nmar_0616 3.2e-82 272.0 arCOG08231@1|root,arCOG08231@2157|Archaea,41T6Q@651137|Thaumarchaeota 651137|Thaumarchaeota L Lamin Tail Domain - - - - - - - - - - - - LTD k59_21434_1 765952.PUV_08500 7.19e-05 47.8 COG1109@1|root,COG1109@2|Bacteria,2JFUP@204428|Chlamydiae 204428|Chlamydiae G Phosphoglucomutase phosphomannomutase pgcA - 5.4.2.8 ko:K01840 ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130 M00114 R01818 RC00408 ko00000,ko00001,ko00002,ko01000 - - - PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV k59_1715978_2 1123367.C666_11415 6.09e-15 77.0 COG4638@1|root,COG4638@2|Bacteria,1MWXW@1224|Proteobacteria,2VJT8@28216|Betaproteobacteria 28216|Betaproteobacteria P Rieske 2Fe-2S - - - - - - - - - - - - Rieske,Ring_hydroxyl_A k59_528331_2 211586.SO_1777 2.09e-37 136.0 COG3005@1|root,COG3005@2|Bacteria,1R4UP@1224|Proteobacteria,1RZUI@1236|Gammaproteobacteria,2QAN2@267890|Shewanellaceae 1236|Gammaproteobacteria C TIGRFAM cytochrome C family protein - - - - - - - - - - - - Cytochrome_C554,Paired_CXXCH_1 k59_190745_1 886377.Murru_3006 1.94e-148 427.0 COG2801@1|root,COG2963@1|root,COG2801@2|Bacteria,COG2963@2|Bacteria,4NJ32@976|Bacteroidetes,1HZH2@117743|Flavobacteriia 976|Bacteroidetes L Pfam Integrase core domain - - - - - - - - - - - - HTH_32,rve,rve_3 k59_190745_2 864069.MicloDRAFT_00051360 1.69e-39 137.0 COG2963@1|root,COG2963@2|Bacteria,1RHKX@1224|Proteobacteria,2U9TV@28211|Alphaproteobacteria,1JVFR@119045|Methylobacteriaceae 28211|Alphaproteobacteria L Transposase - - - ko:K07483 - - - - ko00000 - - - HTH_Tnp_1 k59_416389_1 1448139.AI20_12990 2.76e-69 220.0 COG1960@1|root,COG1960@2|Bacteria,1MUK0@1224|Proteobacteria,1RNBX@1236|Gammaproteobacteria 1236|Gammaproteobacteria I acyl-CoA dehydrogenase gcdH - 1.3.8.6 ko:K00252 ko00071,ko00310,ko00362,ko00380,ko01100,ko01120,ko01130,map00071,map00310,map00362,map00380,map01100,map01120,map01130 M00032 R02487,R02488,R10074 RC00052,RC00156 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_472528_1 396588.Tgr7_0032 7.65e-29 116.0 COG2972@1|root,COG2972@2|Bacteria,1MXVQ@1224|Proteobacteria,1RQDA@1236|Gammaproteobacteria,1WYMY@135613|Chromatiales 135613|Chromatiales T Histidine kinase - - 2.7.13.3 ko:K08082 ko02020,map02020 M00493 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - His_kinase k59_1207643_1 1049564.TevJSym_ac00880 5.84e-20 93.2 2BFY8@1|root,329TX@2|Bacteria,1R582@1224|Proteobacteria,1RY97@1236|Gammaproteobacteria,1JBX1@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S membrane - - - - - - - - - - - - DUF2232 k59_642142_1 1122137.AQXF01000004_gene1789 3.91e-68 209.0 COG0394@1|root,COG0394@2|Bacteria,1RANV@1224|Proteobacteria,2U5EE@28211|Alphaproteobacteria 28211|Alphaproteobacteria T Belongs to the low molecular weight phosphotyrosine protein phosphatase family MA20_21085 - 1.20.4.1,3.1.3.48 ko:K01104,ko:K03741 - - - - ko00000,ko01000 - - - LMWPc k59_642142_2 1122137.AQXF01000004_gene1790 3.29e-96 282.0 COG5328@1|root,COG5328@2|Bacteria,1RA93@1224|Proteobacteria,2U741@28211|Alphaproteobacteria 28211|Alphaproteobacteria T Belongs to the UPF0262 family MA20_21090 - - - - - - - - - - - UPF0262 k59_642142_3 1122137.AQXF01000004_gene1791 4.34e-09 56.6 COG0141@1|root,COG0141@2|Bacteria,1MUUF@1224|Proteobacteria,2TSBN@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine hisD GO:0000105,GO:0003674,GO:0003824,GO:0004399,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0052803,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.23 ko:K00013 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R01158,R01163,R03012 RC00099,RC00242,RC00463 ko00000,ko00001,ko00002,ko01000 - - - Histidinol_dh k59_78790_1 998088.B565_0546 3.7e-65 212.0 COG0111@1|root,COG0111@2|Bacteria,1MW1U@1224|Proteobacteria,1RRQE@1236|Gammaproteobacteria,1Y4JE@135624|Aeromonadales 135624|Aeromonadales EH D-isomer specific 2-hydroxyacid dehydrogenase - - 1.1.1.79,1.1.1.81 ko:K12972 ko00260,ko00620,ko00630,ko01100,ko01110,ko01120,map00260,map00620,map00630,map01100,map01110,map01120 - R00465,R01388,R01392,R02527 RC00031,RC00042,RC00670 ko00000,ko00001,ko01000 - - - 2-Hacid_dh_C k59_361003_1 34506.g2136 8.65e-22 94.4 COG3004@1|root,2RXDF@2759|Eukaryota,3AG09@33154|Opisthokonta,3BZKK@33208|Metazoa,3DDJ9@33213|Bilateria 33208|Metazoa P Na+/H+ antiporter 1 - - - - - - - - - - - - Na_H_antiport_1 k59_585978_1 1163617.SCD_n00896 1.51e-54 185.0 COG3034@1|root,COG3034@2|Bacteria,1N2B6@1224|Proteobacteria,2VJXB@28216|Betaproteobacteria 28216|Betaproteobacteria S ErfK YbiS YcfS YnhG family protein - - - - - - - - - - - - YkuD k59_304425_1 1415778.JQMM01000001_gene531 1.17e-08 55.5 COG0288@1|root,COG0288@2|Bacteria,1NGFN@1224|Proteobacteria,1RSY6@1236|Gammaproteobacteria,1J5S3@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P Reversible hydration of carbon dioxide can GO:0003674,GO:0003824,GO:0004089,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008270,GO:0015976,GO:0016829,GO:0016835,GO:0016836,GO:0043167,GO:0043169,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914 4.2.1.1 ko:K01673 ko00910,map00910 - R00132,R10092 RC02807 ko00000,ko00001,ko01000 - - iSBO_1134.SBO_0115,iSbBS512_1146.SbBS512_E0119 Pro_CA k59_304425_2 583345.Mmol_0577 1.66e-21 99.4 COG4783@1|root,COG4783@2|Bacteria,1MVFV@1224|Proteobacteria,2VJK2@28216|Betaproteobacteria,2KKQ0@206350|Nitrosomonadales 206350|Nitrosomonadales S Peptidase family M48 - - - - - - - - - - - - Peptidase_M48,TPR_16,TPR_8 k59_1263201_1 519989.ECTPHS_03879 5.98e-53 176.0 COG0189@1|root,COG0189@2|Bacteria,1MVUA@1224|Proteobacteria,1RMU0@1236|Gammaproteobacteria,1WVY1@135613|Chromatiales 135613|Chromatiales HJ Belongs to the prokaryotic GSH synthase family gshB - 6.3.2.3 ko:K01920 ko00270,ko00480,ko01100,map00270,map00480,map01100 M00118 R00497,R10994 RC00096,RC00141 ko00000,ko00001,ko00002,ko01000 - - - GSH-S_ATP,GSH-S_N k59_416408_1 34506.g5746 3.46e-35 139.0 2D230@1|root,2SK8Y@2759|Eukaryota,3AIMH@33154|Opisthokonta,3BYUR@33208|Metazoa,3DF2B@33213|Bilateria 33208|Metazoa T His Kinase A (phospho-acceptor) domain - - - - - - - - - - - - HATPase_c,HisKA k59_699149_1 555793.WSK_0325 2.92e-112 332.0 COG1392@1|root,COG1392@2|Bacteria,1QV5N@1224|Proteobacteria,2TWA9@28211|Alphaproteobacteria,2K1CT@204457|Sphingomonadales 204457|Sphingomonadales P Phosphate transport regulator - - - ko:K07220 - - - - ko00000 - - - NUDIX,PhoU_div k59_1771844_1 436308.Nmar_0229 5.87e-93 288.0 COG0532@1|root,arCOG01560@2157|Archaea,41SBY@651137|Thaumarchaeota 651137|Thaumarchaeota J Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2 infB - - ko:K03243 ko03013,map03013 - - - ko00000,ko00001,ko03012 - - - GTP_EFTU,GTP_EFTU_D4,IF-2 k59_1716018_1 666681.M301_1474 4.68e-37 134.0 COG1398@1|root,COG1398@2|Bacteria,1N2MA@1224|Proteobacteria,2VMFC@28216|Betaproteobacteria,2KKMK@206350|Nitrosomonadales 206350|Nitrosomonadales I Fatty acid desaturase - - 1.14.19.1 ko:K00507 ko01040,ko01212,ko03320,ko04152,ko04212,map01040,map01212,map03320,map04152,map04212 - R02222 RC00917 ko00000,ko00001,ko01000,ko01004 - - - FA_desaturase k59_586004_1 1120973.AQXL01000129_gene2453 4.76e-93 286.0 COG0161@1|root,COG0161@2|Bacteria,1TP9N@1239|Firmicutes,4H9QK@91061|Bacilli,2784C@186823|Alicyclobacillaceae 91061|Bacilli H Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor bioA - 2.6.1.105,2.6.1.62 ko:K00833,ko:K19563 ko00780,ko01100,map00780,map01100 M00123,M00573,M00577 R03231,R10699 RC00006,RC00062,RC00887 ko00000,ko00001,ko00002,ko01000,ko01007 - - iSB619.SA_RS12705 Aminotran_3 k59_361042_1 1415778.JQMM01000001_gene473 2.02e-38 147.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1J4MB@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_472559_1 876044.IMCC3088_2220 7.88e-23 99.0 COG1292@1|root,COG1292@2|Bacteria,1MV0K@1224|Proteobacteria,1RP3E@1236|Gammaproteobacteria,1J5HD@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria U Belongs to the BCCT transporter (TC 2.A.15) family - - - ko:K03451 - - - - ko00000 2.A.15 - - BCCT k59_472559_2 1122612.AUBA01000023_gene3192 6.55e-48 159.0 2DMP1@1|root,32SS8@2|Bacteria,1NC27@1224|Proteobacteria,2VGQE@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Protein of unknown function (DUF3237) - - - - - - - - - - - - DUF3237 k59_1716029_1 1121875.KB907550_gene638 5.23e-54 185.0 COG5361@1|root,COG5361@2|Bacteria,4NKSK@976|Bacteroidetes,1IARY@117743|Flavobacteriia 976|Bacteroidetes S Protein of unknown function (DUF1254) - - - - - - - - - - - - DUF1214,DUF1254 k59_1150819_1 517417.Cpar_1153 2.11e-52 179.0 COG1092@1|root,COG1092@2|Bacteria,1FDS5@1090|Chlorobi 1090|Chlorobi J SMART PUA domain containing protein - - 2.1.1.191 ko:K06969 - - - - ko00000,ko01000,ko03009 - - - Methyltrans_SAM k59_1320486_1 1088721.NSU_3439 7.74e-96 298.0 COG3119@1|root,COG3119@2|Bacteria,1MV0B@1224|Proteobacteria,2TRI6@28211|Alphaproteobacteria,2KCQN@204457|Sphingomonadales 204457|Sphingomonadales P Domain of unknown function (DUF4976) - - - - - - - - - - - - DUF4976,Sulfatase k59_134399_1 1122137.AQXF01000003_gene2193 9.82e-72 233.0 COG1766@1|root,COG1766@2|Bacteria,1MUQR@1224|Proteobacteria,2TR6J@28211|Alphaproteobacteria 28211|Alphaproteobacteria N The M ring may be actively involved in energy transduction fliF - - ko:K02409 ko02040,map02040 - - - ko00000,ko00001,ko02035,ko02044 3.A.6.2,3.A.6.3 - - YscJ_FliF,YscJ_FliF_C k59_304474_1 1317124.DW2_03019 8.76e-94 282.0 COG0725@1|root,COG0725@2|Bacteria,1NACV@1224|Proteobacteria,2U20P@28211|Alphaproteobacteria 28211|Alphaproteobacteria P Bacterial extracellular solute-binding protein - - - ko:K02020 ko02010,map02010 M00189 - - ko00000,ko00001,ko00002,ko02000 3.A.1.8 - - SBP_bac_11 k59_1263230_2 1125863.JAFN01000001_gene647 8.02e-82 247.0 COG0811@1|root,COG0811@2|Bacteria,1PKF8@1224|Proteobacteria,42TN7@68525|delta/epsilon subdivisions,2WQK7@28221|Deltaproteobacteria 28221|Deltaproteobacteria U PFAM MotA TolQ ExbB proton channel - - - ko:K03561 - - - - ko00000,ko02000 1.A.30.2.1 - - MotA_ExbB k59_528375_1 243277.VC_0473 1.84e-75 246.0 COG0021@1|root,COG0021@2|Bacteria,1MUEY@1224|Proteobacteria,1RMWP@1236|Gammaproteobacteria,1XSX1@135623|Vibrionales 135623|Vibrionales G Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate tkt GO:0003674,GO:0003824,GO:0004802,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009987,GO:0016740,GO:0016744,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0046496,GO:0051156,GO:0051186,GO:0055086,GO:0071704,GO:0072524,GO:1901135,GO:1901360,GO:1901564 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 - - - Transket_pyr,Transketolase_C,Transketolase_N k59_134411_1 1122137.AQXF01000003_gene1986 2.52e-162 470.0 COG1207@1|root,COG1207@2|Bacteria,1MUPH@1224|Proteobacteria,2TQPS@28211|Alphaproteobacteria 28211|Alphaproteobacteria M Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain glmU - 2.3.1.157,2.7.7.23 ko:K04042,ko:K11528 ko00520,ko01100,ko01130,map00520,map01100,map01130 M00362 R00416,R05332 RC00002,RC00004,RC00166 ko00000,ko00001,ko00002,ko01000 - - - Hexapep,NTP_transf_3 k59_1377770_1 1163617.SCD_n00732 1.09e-55 192.0 COG1807@1|root,COG1807@2|Bacteria,1PUE3@1224|Proteobacteria,2VHPU@28216|Betaproteobacteria 28216|Betaproteobacteria M 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family - - - - - - - - - - - - PMT_2 k59_1432865_1 555779.Dthio_PD0837 4.9e-14 78.6 COG0642@1|root,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,42M0Y@68525|delta/epsilon subdivisions,2WIR4@28221|Deltaproteobacteria,2M7T3@213115|Desulfovibrionales 28221|Deltaproteobacteria T histidine kinase A domain protein - - - - - - - - - - - - HAMP,HATPase_c,HisKA,PAS_3,PAS_4,PAS_9,Response_reg k59_1263238_1 1121918.ARWE01000001_gene737 3.55e-36 142.0 COG1450@1|root,COG1450@2|Bacteria,1MUUA@1224|Proteobacteria,42M9I@68525|delta/epsilon subdivisions,2WK1H@28221|Deltaproteobacteria,43UC5@69541|Desulfuromonadales 28221|Deltaproteobacteria NU Bacterial type II/III secretion system short domain gspD - - ko:K02453 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - Secretin,Secretin_N k59_1604517_1 436308.Nmar_0341 2.01e-32 122.0 COG1104@1|root,arCOG00066@2157|Archaea,41SB1@651137|Thaumarchaeota 651137|Thaumarchaeota E Cysteine desulfurase - - 2.8.1.7 ko:K04487 ko00730,ko01100,ko04122,map00730,map01100,map04122 - R07460,R11528,R11529 RC01789,RC02313 ko00000,ko00001,ko01000,ko02048,ko03016,ko03029 - - - Aminotran_5 k59_1604517_2 1229909.NSED_01645 6.16e-20 88.2 arCOG08033@1|root,arCOG08643@1|root,arCOG08033@2157|Archaea,arCOG08643@2157|Archaea,41T3A@651137|Thaumarchaeota 651137|Thaumarchaeota S peptidyl-tyrosine sulfation - - - - - - - - - - - - - k59_643027_1 95619.PM1_0218070 3.38e-50 178.0 COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,1RN3H@1236|Gammaproteobacteria 1236|Gammaproteobacteria KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance relA GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008728,GO:0008893,GO:0009116,GO:0009117,GO:0009119,GO:0009150,GO:0009259,GO:0009605,GO:0009987,GO:0009991,GO:0015949,GO:0015969,GO:0016020,GO:0016740,GO:0016772,GO:0016778,GO:0016787,GO:0016788,GO:0016794,GO:0019637,GO:0019693,GO:0030312,GO:0031667,GO:0033865,GO:0033875,GO:0034032,GO:0034035,GO:0034641,GO:0042278,GO:0042578,GO:0042594,GO:0044237,GO:0044238,GO:0044281,GO:0044464,GO:0046128,GO:0046483,GO:0050896,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:1901068,GO:1901135,GO:1901360,GO:1901564,GO:1901657 2.7.6.5 ko:K00951 ko00230,map00230 - R00429 RC00002,RC00078 ko00000,ko00001,ko01000 - - iSFV_1184.SFV_2673 ACT_4,HD_4,RelA_SpoT,TGS k59_1772595_1 1232683.ADIMK_1392 1.32e-49 167.0 COG1119@1|root,COG1119@2|Bacteria,1MVVM@1224|Proteobacteria,1RMXK@1236|Gammaproteobacteria,464GQ@72275|Alteromonadaceae 1236|Gammaproteobacteria P ABC-type molybdenum transport system, ATPase component photorepair protein PhrA modF GO:0000166,GO:0003674,GO:0005488,GO:0005524,GO:0008144,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0097159,GO:0097367,GO:1901265,GO:1901363 3.6.3.34 ko:K02013,ko:K05776 ko02010,map02010 M00189,M00240 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.14 - - ABC_tran k59_1660765_1 272630.MexAM1_META1p3978 4.27e-47 163.0 COG4643@1|root,COG4643@2|Bacteria,1MW9E@1224|Proteobacteria,2TS3B@28211|Alphaproteobacteria,1JWRA@119045|Methylobacteriaceae 28211|Alphaproteobacteria S Toprim domain - - - ko:K06919 - - - - ko00000 - - - Toprim_3,zf-CHC2 k59_248064_1 1122137.AQXF01000001_gene3376 4.32e-147 432.0 COG0441@1|root,COG0441@2|Bacteria,1MUP2@1224|Proteobacteria,2TQWI@28211|Alphaproteobacteria 28211|Alphaproteobacteria J Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) thrS - 6.1.1.3 ko:K01868 ko00970,map00970 M00359,M00360 R03663 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,TGS,tRNA-synt_2b,tRNA_SAD k59_248064_2 1122137.AQXF01000001_gene3377 3.51e-11 62.0 COG1073@1|root,COG1073@2|Bacteria,1MX88@1224|Proteobacteria,2TSRE@28211|Alphaproteobacteria 28211|Alphaproteobacteria S hydrolases or acyltransferases (alpha beta hydrolase superfamily) MA20_24420 - - ko:K06889 - - - - ko00000 - - - Abhydrolase_6,Hydrolase_4 k59_870856_1 1469245.JFBG01000002_gene447 1.19e-15 77.0 COG0810@1|root,COG0810@2|Bacteria 2|Bacteria M energy transducer activity tolA - - ko:K03646,ko:K03832 - - - - ko00000,ko02000 2.C.1.1,2.C.1.2 - - TonB_2 k59_870856_2 1117318.PRUB_00365 7.51e-18 83.6 COG0823@1|root,COG0823@2|Bacteria,1MV09@1224|Proteobacteria,1RMCY@1236|Gammaproteobacteria,2Q1NJ@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria U Involved in the TonB-independent uptake of proteins tolB GO:0003674,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006810,GO:0008104,GO:0008150,GO:0009719,GO:0009987,GO:0010033,GO:0010243,GO:0015031,GO:0015833,GO:0015893,GO:0017038,GO:0019904,GO:0030288,GO:0030313,GO:0031975,GO:0032153,GO:0032991,GO:0033036,GO:0042221,GO:0042493,GO:0042597,GO:0042886,GO:0042891,GO:0043213,GO:0044464,GO:0044877,GO:0045184,GO:0046677,GO:0046678,GO:0050896,GO:0051179,GO:0051234,GO:0051716,GO:0070887,GO:0071236,GO:0071237,GO:0071310,GO:0071417,GO:0071495,GO:0071702,GO:0071705,GO:1901652,GO:1901653,GO:1901698,GO:1901699,GO:1901700,GO:1901701 - ko:K03641 - - - - ko00000,ko02000 2.C.1.2 - - PD40,TolB_N k59_1717317_1 1121937.AUHJ01000001_gene680 6.05e-32 119.0 COG0583@1|root,COG0583@2|Bacteria,1MWVU@1224|Proteobacteria,1RPT8@1236|Gammaproteobacteria,465VQ@72275|Alteromonadaceae 1236|Gammaproteobacteria K Transcriptional regulator finR - - - - - - - - - - - HTH_1,LysR_substrate k59_1717317_2 693986.MOC_2203 1.04e-28 109.0 COG1018@1|root,COG1018@2|Bacteria,1MW37@1224|Proteobacteria,2TVXU@28211|Alphaproteobacteria,1JRTI@119045|Methylobacteriaceae 28211|Alphaproteobacteria C PFAM oxidoreductase FAD NAD(P)-binding domain protein fpr - 1.18.1.2,1.19.1.1 ko:K00528 - - R10159 - ko00000,ko01000 - - - FAD_binding_6,NAD_binding_1 k59_1321378_1 455632.SGR_2971 1.19e-23 104.0 COG1007@1|root,COG1007@2|Bacteria,2GMGX@201174|Actinobacteria,418GV@629295|Streptomyces griseus group 201174|Actinobacteria C Proton-conducting membrane transporter nuoN GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 1.6.5.3 ko:K00343 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Proton_antipo_M k59_1264057_1 1088721.NSU_0267 2.68e-113 340.0 COG0342@1|root,COG0342@2|Bacteria,1MV5U@1224|Proteobacteria,2TQYG@28211|Alphaproteobacteria,2K1DA@204457|Sphingomonadales 204457|Sphingomonadales U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA secD - - ko:K03072 ko03060,ko03070,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 2.A.6.4,3.A.5.2,3.A.5.7 - - SecD_SecF,Sec_GG k59_1604547_1 1122137.AQXF01000001_gene2963 9.66e-33 127.0 COG0642@1|root,COG2205@2|Bacteria,1MVY8@1224|Proteobacteria,2TS5B@28211|Alphaproteobacteria 28211|Alphaproteobacteria T Histidine kinase divL GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - - - - - - - - - - HATPase_c,HisKA,PAS_7,PAS_8 k59_1604547_2 1122137.AQXF01000001_gene2962 4.34e-64 201.0 COG0802@1|root,COG0802@2|Bacteria,1RGYU@1224|Proteobacteria,2UBQ9@28211|Alphaproteobacteria 28211|Alphaproteobacteria S ATPase or kinase - - 2.7.1.221 ko:K06925,ko:K07102 ko00520,ko01100,map00520,map01100 - R08968,R11024 RC00002,RC00078 ko00000,ko00001,ko01000,ko03016 - - - TsaE k59_1604547_3 1156937.MFUM_130008 0.000168 44.3 COG1209@1|root,COG1209@2|Bacteria,46T9Q@74201|Verrucomicrobia,37GNV@326457|unclassified Verrucomicrobia 74201|Verrucomicrobia M Nucleotidyl transferase - - 2.3.1.157,2.7.7.23 ko:K04042 ko00520,ko01100,ko01130,map00520,map01100,map01130 M00362 R00416,R05332 RC00002,RC00004,RC00166 ko00000,ko00001,ko00002,ko01000 - - - NTP_transferase k59_22732_1 309801.trd_1336 2.46e-38 145.0 COG1316@1|root,COG1316@2|Bacteria 2|Bacteria K TRANSCRIPTIONal - - - - - - - - - - - - LytR_cpsA_psr k59_1040597_1 1236541.BALL01000016_gene2244 4e-12 70.5 COG4942@1|root,COG4942@2|Bacteria,1MY3E@1224|Proteobacteria,1RPQP@1236|Gammaproteobacteria,2QAS9@267890|Shewanellaceae 1236|Gammaproteobacteria D Peptidase M23B envC GO:0000920,GO:0001896,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008219,GO:0009273,GO:0009314,GO:0009628,GO:0009987,GO:0012501,GO:0016020,GO:0016787,GO:0030288,GO:0030313,GO:0031975,GO:0032153,GO:0042221,GO:0042493,GO:0042546,GO:0042597,GO:0043085,GO:0044085,GO:0044093,GO:0044464,GO:0050790,GO:0050896,GO:0051301,GO:0051336,GO:0051345,GO:0065007,GO:0065009,GO:0071554,GO:0071840,GO:0071944 - - - - - - - - - - Peptidase_M23 k59_362352_1 395494.Galf_2662 7.45e-31 116.0 COG0042@1|root,COG0042@2|Bacteria,1MV5V@1224|Proteobacteria,2VHBP@28216|Betaproteobacteria,44UYZ@713636|Nitrosomonadales 28216|Betaproteobacteria H Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines dusB - - ko:K05540 - - - - ko00000,ko01000,ko03016 - - - Dus k59_141823_2 439235.Dalk_2188 5.45e-31 120.0 COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,42MK4@68525|delta/epsilon subdivisions,2WJJ8@28221|Deltaproteobacteria,2MI9P@213118|Desulfobacterales 28221|Deltaproteobacteria G PFAM TRAP C4-dicarboxylate transport system permease DctM subunit - - - - - - - - - - - - DctM,DctQ k59_29769_1 1122137.AQXF01000002_gene301 1.22e-158 454.0 COG0349@1|root,COG0349@2|Bacteria,1MURV@1224|Proteobacteria,2TSQM@28211|Alphaproteobacteria 28211|Alphaproteobacteria J Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides rnd - 3.1.13.5 ko:K03684 - - - - ko00000,ko01000,ko03016 - - - DNA_pol_A_exo1,HRDC k59_707132_1 324057.Pjdr2_2412 3.48e-18 79.0 COG0105@1|root,COG0105@2|Bacteria,1V44G@1239|Firmicutes,4HH8C@91061|Bacilli,26XG6@186822|Paenibacillaceae 91061|Bacilli F Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate ndk GO:0003674,GO:0003824,GO:0004550,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006165,GO:0006220,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009132,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0019205,GO:0019637,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0044464,GO:0046483,GO:0046939,GO:0055086,GO:0071704,GO:0072521,GO:0072527,GO:1901360,GO:1901564 2.7.4.6 ko:K00940 ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016 M00049,M00050,M00052,M00053 R00124,R00139,R00156,R00330,R00570,R00722,R01137,R01857,R02093,R02326,R02331,R03530,R11894,R11895 RC00002 ko00000,ko00001,ko00002,ko01000,ko04131 - - - NDK k59_196898_1 870187.Thini_3697 1.81e-74 236.0 COG0628@1|root,COG0628@2|Bacteria,1MW0B@1224|Proteobacteria,1RPVP@1236|Gammaproteobacteria,45ZYG@72273|Thiotrichales 72273|Thiotrichales S AI-2E family transporter - - - - - - - - - - - - AI-2E_transport k59_1100262_1 316407.1736760 9.03e-83 246.0 COG0110@1|root,COG0110@2|Bacteria,1R6A3@1224|Proteobacteria,1RQXV@1236|Gammaproteobacteria,3XN6J@561|Escherichia 1236|Gammaproteobacteria S slime layer organization wcaF GO:0003674,GO:0003824,GO:0008374,GO:0016740,GO:0016746,GO:0016747 - ko:K03818 - - - - ko00000,ko01000 - - - Hexapep k59_1100262_2 316407.1736759 1.87e-43 150.0 COG1089@1|root,COG1089@2|Bacteria,1MUX0@1224|Proteobacteria,1RMIY@1236|Gammaproteobacteria,3XMI8@561|Escherichia 1236|Gammaproteobacteria F Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose gmd GO:0003674,GO:0003824,GO:0008446,GO:0016829,GO:0016835,GO:0016836 4.2.1.47 ko:K01711 ko00051,ko00520,ko01100,map00051,map00520,map01100 - R00888 RC00402 ko00000,ko00001,ko01000 - - - GDP_Man_Dehyd k59_1555799_1 158500.BV97_00544 1.23e-58 189.0 COG3063@1|root,COG3063@2|Bacteria,1P78I@1224|Proteobacteria,2UX2I@28211|Alphaproteobacteria 28211|Alphaproteobacteria NU Tetratricopeptide repeat - - - - - - - - - - - - TPR_8 k59_1385680_1 1260251.SPISAL_06875 1.55e-56 179.0 COG2001@1|root,COG2001@2|Bacteria,1RHCG@1224|Proteobacteria,1S63F@1236|Gammaproteobacteria,1WYVR@135613|Chromatiales 135613|Chromatiales K Belongs to the MraZ family mraZ - - ko:K03925 - - - - ko00000 - - - MraZ k59_1385680_2 1123053.AUDG01000021_gene492 2.14e-11 63.2 COG0275@1|root,COG0275@2|Bacteria,1MUT4@1224|Proteobacteria,1RM7M@1236|Gammaproteobacteria,1WX5B@135613|Chromatiales 135613|Chromatiales J Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA rsmH - 2.1.1.199 ko:K03438 - - - - ko00000,ko01000,ko03009 - - - Methyltransf_5 k59_86891_1 1122137.AQXF01000005_gene1259 2.21e-97 298.0 COG4799@1|root,COG4799@2|Bacteria,1MVAX@1224|Proteobacteria,2TRV6@28211|Alphaproteobacteria 28211|Alphaproteobacteria I acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) MA20_22955 - 6.4.1.5 ko:K13778 ko00281,map00281 - R03494 RC00367,RC00942 ko00000,ko00001,ko01000 - - - Carboxyl_trans k59_86891_2 1122137.AQXF01000005_gene1260 5.81e-239 661.0 COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,2TR15@28211|Alphaproteobacteria 28211|Alphaproteobacteria I acyl-CoA dehydrogenase MA20_22975 - - ko:K11731 ko00281,map00281 - R08089 RC01893 ko00000,ko00001,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_86891_3 1122137.AQXF01000005_gene1261 8.35e-68 214.0 COG1024@1|root,COG1024@2|Bacteria,1MVEC@1224|Proteobacteria,2TRPS@28211|Alphaproteobacteria 28211|Alphaproteobacteria I Enoyl-CoA hydratase - - 4.1.2.41,4.2.1.101,4.2.1.57 ko:K13779,ko:K18383 ko00281,ko00360,ko01100,ko01110,map00281,map00360,map01100,map01110 - R03493,R05772,R05773 RC00307,RC00941,RC01468,RC01828 ko00000,ko00001,ko01000 - - - ECH_1 k59_422702_1 762550.LEGAS_0867 1.15e-11 67.0 COG0681@1|root,COG0681@2|Bacteria,1V7H9@1239|Firmicutes,4HMGQ@91061|Bacilli,4AXMM@81850|Leuconostocaceae 91061|Bacilli U Belongs to the peptidase S26 family lepB - 3.4.21.89 ko:K03100 ko02024,ko03060,map02024,map03060 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_S24,Peptidase_S26 k59_1215491_1 498211.CJA_1010 3.04e-18 78.6 COG3296@1|root,COG3296@2|Bacteria,1RET3@1224|Proteobacteria,1S4H0@1236|Gammaproteobacteria,1FHSF@10|Cellvibrio 1236|Gammaproteobacteria S Domain of unknown function (DUF4870) - - - ko:K09940 - - - - ko00000 - - - DUF4870 k59_1776727_1 626887.J057_23615 1.56e-51 174.0 COG0527@1|root,COG0527@2|Bacteria,1MW3H@1224|Proteobacteria,1RN1G@1236|Gammaproteobacteria,465C7@72275|Alteromonadaceae 1236|Gammaproteobacteria E Belongs to the aspartokinase family lysC GO:0003674,GO:0003824,GO:0004072,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0019202,GO:0044237 2.7.2.4 ko:K00928 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00017,M00018,M00033,M00525,M00526,M00527 R00480 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase,ACT,ACT_7 k59_196920_1 396588.Tgr7_2119 8.62e-27 109.0 COG0188@1|root,COG0188@2|Bacteria,1MURI@1224|Proteobacteria,1RMTC@1236|Gammaproteobacteria,1WWE3@135613|Chromatiales 135613|Chromatiales L Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule parC - - ko:K02621 - - - - ko00000,ko01000,ko02048,ko03032,ko03036 - - - DNA_gyraseA_C,DNA_topoisoIV k59_1269284_1 1537994.JQFW01000031_gene965 1.64e-79 253.0 COG0593@1|root,COG0593@2|Bacteria,1MU5H@1224|Proteobacteria,1RNHP@1236|Gammaproteobacteria,46444@72275|Alteromonadaceae 1236|Gammaproteobacteria L it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids dnaA GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003688,GO:0003690,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006275,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010556,GO:0016020,GO:0017076,GO:0019219,GO:0019222,GO:0030554,GO:0031323,GO:0031326,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0035639,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0051052,GO:0051171,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0090304,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901363,GO:1901576,GO:1990837,GO:2000112 - ko:K02313 ko02020,ko04112,map02020,map04112 - - - ko00000,ko00001,ko03032,ko03036 - - - Bac_DnaA,Bac_DnaA_C,DnaA_N k59_141847_1 436308.Nmar_0667 9.61e-79 241.0 COG1478@1|root,arCOG02714@2157|Archaea,41T27@651137|Thaumarchaeota 651137|Thaumarchaeota H F420-0:Gamma-glutamyl ligase - - 6.3.2.31,6.3.2.34 ko:K12234 ko00680,ko01120,map00680,map01120 M00378 R09399,R09400 RC00064,RC00090,RC00141 ko00000,ko00001,ko00002,ko01000 - - - F420_ligase k59_141847_2 1229909.NSED_03385 2.04e-124 357.0 COG0560@1|root,arCOG01158@2157|Archaea,41SHX@651137|Thaumarchaeota 651137|Thaumarchaeota E phosphoserine phosphatase - - 3.1.3.3 ko:K01079 ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230 M00020 R00582 RC00017 ko00000,ko00001,ko00002,ko01000,ko01009 - - - HAD k59_1157763_2 158500.BV97_04527 2.17e-99 299.0 COG2141@1|root,COG2141@2|Bacteria,1MUVN@1224|Proteobacteria,2TR26@28211|Alphaproteobacteria,2K2K6@204457|Sphingomonadales 204457|Sphingomonadales C monooxygenase - - - - - - - - - - - - Bac_luciferase k59_1100284_1 1211114.ALIP01000029_gene2570 2.92e-110 330.0 COG2115@1|root,COG2115@2|Bacteria,1MXS2@1224|Proteobacteria,1RN5Y@1236|Gammaproteobacteria,1X4B9@135614|Xanthomonadales 135614|Xanthomonadales G Belongs to the xylose isomerase family xylA GO:0003674,GO:0003824,GO:0005975,GO:0005996,GO:0008150,GO:0008152,GO:0009045,GO:0009056,GO:0016052,GO:0016853,GO:0016860,GO:0016861,GO:0019321,GO:0019323,GO:0042732,GO:0042843,GO:0044238,GO:0044281,GO:0044282,GO:0046365,GO:0071704,GO:1901575 5.3.1.5 ko:K01805 ko00040,ko00051,ko01100,map00040,map00051,map01100 - R00878,R01432 RC00376,RC00516 ko00000,ko00001,ko01000 - - - - k59_1665954_1 311402.Avi_5350 2.58e-93 284.0 COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,2TQKK@28211|Alphaproteobacteria,4BBR1@82115|Rhizobiaceae 28211|Alphaproteobacteria EP ABC-type dipeptide oligopeptide nickel transport systems, permease components dppB GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K02033,ko:K12369 ko02010,ko02024,map02010,map02024 M00239,M00324 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1 k59_1499089_1 366649.XFF4834R_chr41530 1.44e-55 189.0 COG0266@1|root,COG0266@2|Bacteria,1MVM5@1224|Proteobacteria,1RP3J@1236|Gammaproteobacteria,1X3ZV@135614|Xanthomonadales 135614|Xanthomonadales L Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates fpg - 3.2.2.23,4.2.99.18 ko:K10563 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - Fapy_DNA_glyco,H2TH,zf-FPG_IleRS k59_1776738_2 1120949.KB903357_gene4924 6.59e-24 101.0 COG1272@1|root,COG1272@2|Bacteria,2GJGQ@201174|Actinobacteria,4D99Y@85008|Micromonosporales 201174|Actinobacteria S protein, hemolysin III - - - ko:K11068 - - - - ko00000,ko02042 - - - HlyIII k59_1385711_1 1307834.BARL01000001_gene181 1.8e-60 206.0 COG2303@1|root,COG2303@2|Bacteria,1MU3F@1224|Proteobacteria,2TT3C@28211|Alphaproteobacteria,2JRMB@204441|Rhodospirillales 204441|Rhodospirillales E GMC oxidoreductase - - - - - - - - - - - - FAD_binding_2,GMC_oxred_C,GMC_oxred_N k59_29817_1 948565.AFFP02000027_gene177 9.62e-22 93.2 COG0712@1|root,COG0712@2|Bacteria,1MVRH@1224|Proteobacteria,1S8X2@1236|Gammaproteobacteria,1Y7GZ@135625|Pasteurellales 135625|Pasteurellales C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation atpH - - ko:K02113 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - OSCP k59_1555833_1 1173024.KI912149_gene5690 1.24e-17 87.8 COG0642@1|root,COG0745@1|root,COG0784@1|root,COG2202@1|root,COG2203@1|root,COG0745@2|Bacteria,COG0784@2|Bacteria,COG2202@2|Bacteria,COG2203@2|Bacteria,COG2205@2|Bacteria,1G09B@1117|Cyanobacteria,1JK6C@1189|Stigonemataceae 1117|Cyanobacteria T Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) - - - - - - - - - - - - GAF_2,HATPase_c,HisKA,PAS_3,PAS_4,PAS_9,Response_reg k59_1100287_1 1317118.ATO8_13137 2.42e-35 137.0 COG1042@1|root,COG1042@2|Bacteria,1MW98@1224|Proteobacteria,2TR24@28211|Alphaproteobacteria,4KM7X@93682|Roseivivax 28211|Alphaproteobacteria C CoA binding domain - - - - - - - - - - - - ATP-grasp_5,CoA_binding_2,Succ_CoA_lig k59_1555834_1 1122225.AULQ01000002_gene530 7.82e-26 104.0 COG0719@1|root,COG0719@2|Bacteria,4NFPG@976|Bacteroidetes,1HXNA@117743|Flavobacteriia 976|Bacteroidetes O assembly protein, SufD sufD - - ko:K09015 - - - - ko00000 - - - UPF0051 k59_1555834_2 983544.Lacal_1178 6.21e-55 177.0 COG0396@1|root,COG0396@2|Bacteria,4NEMY@976|Bacteroidetes,1HWTU@117743|Flavobacteriia 976|Bacteroidetes O Part of SUF system involved in inserting iron-sulfur clusters into proteins sufC - - ko:K09013 - - - - ko00000,ko02000 - - - ABC_tran k59_533667_1 566466.NOR53_3690 2.81e-88 286.0 COG2866@1|root,COG2866@2|Bacteria,1N9W9@1224|Proteobacteria,1RPC7@1236|Gammaproteobacteria,1J7Z8@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Zinc carboxypeptidase - - - - - - - - - - - - Peptidase_M14 k59_1326134_1 1088721.NSU_4036 5.37e-141 416.0 COG0021@1|root,COG0021@2|Bacteria,1MUEY@1224|Proteobacteria,2TQUX@28211|Alphaproteobacteria,2K0UZ@204457|Sphingomonadales 204457|Sphingomonadales G Belongs to the transketolase family tktA - 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 - - - Transket_pyr,Transketolase_C,Transketolase_N k59_986171_1 316407.21321902 1.04e-72 235.0 COG0443@1|root,COG0443@2|Bacteria,1MVEN@1224|Proteobacteria,1RMDD@1236|Gammaproteobacteria,3XM30@561|Escherichia 1236|Gammaproteobacteria O Heat shock 70 kDa protein dnaK GO:0000166,GO:0000988,GO:0000989,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008144,GO:0008150,GO:0008270,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010033,GO:0010556,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0016989,GO:0017076,GO:0017111,GO:0019219,GO:0019222,GO:0022607,GO:0030554,GO:0031323,GO:0031326,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033554,GO:0034620,GO:0035639,GO:0035966,GO:0035967,GO:0036094,GO:0042221,GO:0043167,GO:0043168,GO:0043169,GO:0043531,GO:0043933,GO:0044085,GO:0044183,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0051171,GO:0051252,GO:0051716,GO:0060255,GO:0061077,GO:0065003,GO:0065007,GO:0070887,GO:0071310,GO:0071840,GO:0071944,GO:0080090,GO:0097159,GO:0097367,GO:0140110,GO:1901265,GO:1901363,GO:1903506,GO:2001141 - ko:K04043 ko03018,ko04212,ko05152,map03018,map04212,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 1.A.33.1 - - HSP70 k59_986171_2 1229485.AMYV01000114_gene3306 1.63e-12 66.2 COG0484@1|root,COG0484@2|Bacteria,1MVMS@1224|Proteobacteria,1RNHY@1236|Gammaproteobacteria,1J4DE@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins dnaJ GO:0000988,GO:0000989,GO:0003674,GO:0003756,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006457,GO:0006458,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010556,GO:0015035,GO:0015036,GO:0016020,GO:0016032,GO:0016043,GO:0016491,GO:0016667,GO:0016853,GO:0016860,GO:0016864,GO:0016989,GO:0019219,GO:0019222,GO:0022607,GO:0031323,GO:0031326,GO:0032991,GO:0034641,GO:0034645,GO:0042026,GO:0043167,GO:0043169,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044403,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0051171,GO:0051252,GO:0051704,GO:0055114,GO:0060255,GO:0061077,GO:0065003,GO:0065007,GO:0071704,GO:0071840,GO:0080090,GO:0090304,GO:0140096,GO:0140110,GO:1901360,GO:1901576,GO:1903506,GO:2001141 - ko:K03686 - - - - ko00000,ko03029,ko03110 - - - DnaJ,DnaJ_C,DnaJ_CXXCXGXG k59_1215548_1 859657.RPSI07_2107 5.27e-103 311.0 COG0174@1|root,COG0174@2|Bacteria,1MUGQ@1224|Proteobacteria,2VHYE@28216|Betaproteobacteria,1K39W@119060|Burkholderiaceae 28216|Betaproteobacteria E glutamine synthetase glnA GO:0003674,GO:0003824,GO:0006725,GO:0008150,GO:0008152,GO:0009987,GO:0016853,GO:0016866,GO:0034022,GO:0042537,GO:0044237,GO:0050486,GO:0071704,GO:1901360 5.4.4.3,6.3.1.2 ko:K01915,ko:K20712 ko00220,ko00250,ko00627,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00627,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 - R00253,R06988,R09284 RC00010,RC01754,RC02798 ko00000,ko00001,ko01000,ko04147 - - - Gln-synt_C,Gln-synt_N k59_987063_1 113355.CM001775_gene1895 1.29e-19 91.3 COG0642@1|root,COG0745@1|root,COG2202@1|root,COG2203@1|root,COG2905@1|root,COG5002@1|root,COG0745@2|Bacteria,COG2202@2|Bacteria,COG2203@2|Bacteria,COG2205@2|Bacteria,COG2905@2|Bacteria,COG5002@2|Bacteria,1G09B@1117|Cyanobacteria 1117|Cyanobacteria T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - CBS,GAF,GAF_2,HATPase_c,HisKA,PAS_3,PAS_9,Response_reg k59_987063_2 1242864.D187_002461 9.87e-09 59.7 COG2203@1|root,COG2203@2|Bacteria,1P3F7@1224|Proteobacteria,4318K@68525|delta/epsilon subdivisions,2WWQB@28221|Deltaproteobacteria,2Z23F@29|Myxococcales 28221|Deltaproteobacteria T Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - - - - - - - - - - GAF_2 k59_1777524_1 1229909.NSED_01510 8.59e-24 96.7 COG1443@1|root,arCOG01081@2157|Archaea,41T09@651137|Thaumarchaeota 651137|Thaumarchaeota I NUDIX domain - - 5.3.3.2 ko:K01823 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00095,M00096,M00364,M00365,M00366,M00367 R01123 RC00455 ko00000,ko00001,ko00002,ko01000 - - - NUDIX k59_1777524_2 1229909.NSED_01505 8.64e-171 483.0 COG0142@1|root,arCOG01726@2157|Archaea,41SEV@651137|Thaumarchaeota 651137|Thaumarchaeota H Belongs to the FPP GGPP synthase family - - 2.5.1.1,2.5.1.10,2.5.1.29 ko:K13787 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00364,M00365 R01658,R02003,R02061 RC00279 ko00000,ko00001,ko00002,ko01000,ko01006 - - - polyprenyl_synt k59_198184_1 204773.HEAR2517 1.18e-53 183.0 COG0475@1|root,COG0475@2|Bacteria,1R9PF@1224|Proteobacteria,2VKV2@28216|Betaproteobacteria,4748Y@75682|Oxalobacteraceae 28216|Betaproteobacteria P Sodium/hydrogen exchanger family - - - - - - - - - - - - Na_H_Exchanger k59_1612249_1 377629.TERTU_4262 2.95e-167 474.0 COG2421@1|root,COG2421@2|Bacteria,1MVRT@1224|Proteobacteria,1RQDU@1236|Gammaproteobacteria,2PNA8@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria C Acetamidase/Formamidase family fmdA - 3.5.1.49 ko:K01455 ko00460,ko00630,ko00910,ko01200,map00460,map00630,map00910,map01200 - R00524 RC02432,RC02810 ko00000,ko00001,ko01000 - - - FmdA_AmdA k59_818541_1 314287.GB2207_09281 3.37e-92 293.0 COG3605@1|root,COG3605@2|Bacteria,1QTTV@1224|Proteobacteria,1T1H2@1236|Gammaproteobacteria,1J4VF@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T Belongs to the PEP-utilizing enzyme family ptsP GO:0003674,GO:0003824,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008965,GO:0009987,GO:0010033,GO:0010243,GO:0016310,GO:0016740,GO:0016772,GO:0016775,GO:0019538,GO:0036211,GO:0042221,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0050896,GO:0071704,GO:1901564,GO:1901698 2.7.3.9 ko:K08484 ko02060,map02060 - - - ko00000,ko00001,ko01000,ko02000 - - - GAF,GAF_2,PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C k59_1557157_1 452637.Oter_3919 2.62e-55 187.0 COG0277@1|root,COG0277@2|Bacteria,46UHB@74201|Verrucomicrobia,3K7CZ@414999|Opitutae 414999|Opitutae C PFAM FAD linked oxidase domain protein - - 1.1.3.15 ko:K00104 ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130 - R00475 RC00042 ko00000,ko00001,ko01000 - - - FAD-oxidase_C,FAD_binding_4 k59_648944_1 95619.PM1_0225755 1.3e-53 170.0 COG3215@1|root,COG3215@2|Bacteria,1RGWZ@1224|Proteobacteria,1S4YE@1236|Gammaproteobacteria 1236|Gammaproteobacteria NU pilus assembly protein, PilZ pilZ - - ko:K02676 - - - - ko00000,ko02035,ko02044 - - - PilZ k59_88180_2 326297.Sama_3542 1.34e-63 197.0 COG0346@1|root,COG0346@2|Bacteria,1RH79@1224|Proteobacteria,1TARI@1236|Gammaproteobacteria,2QD5Q@267890|Shewanellaceae 1236|Gammaproteobacteria E glyoxalase bleomycin resistance protein dioxygenase - - - - - - - - - - - - Glyoxalase k59_88180_4 471853.Bcav_1139 8.16e-35 125.0 COG0454@1|root,COG0454@2|Bacteria,2I32C@201174|Actinobacteria 201174|Actinobacteria K Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_10 k59_88180_5 1234664.AMRO01000003_gene684 1.62e-29 111.0 COG0454@1|root,COG0456@2|Bacteria,1VC1N@1239|Firmicutes,4HJT0@91061|Bacilli,1WGJE@129337|Geobacillus 91061|Bacilli K Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_1,Acetyltransf_10,Acetyltransf_7 k59_1557161_1 580332.Slit_1867 2.83e-27 114.0 COG2230@1|root,COG2230@2|Bacteria,1MX3U@1224|Proteobacteria,2VIPR@28216|Betaproteobacteria 28216|Betaproteobacteria M cyclopropane-fatty-acyl-phospholipid synthase - - 2.1.1.79 ko:K00574 - - - - ko00000,ko01000 - - - CMAS k59_423634_1 1278073.MYSTI_06097 1.04e-66 228.0 COG2937@1|root,COG3320@1|root,COG3774@1|root,COG2937@2|Bacteria,COG3320@2|Bacteria,COG3774@2|Bacteria 2|Bacteria M pathogenesis plsB - 2.3.1.15,6.2.1.3 ko:K00631,ko:K01897 ko00061,ko00071,ko00561,ko00564,ko01100,ko01110,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map00561,map00564,map01100,map01110,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086,M00089 R00851,R01280,R09380 RC00004,RC00014,RC00039,RC00041 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - Acyltransferase,NAD_binding_4,PS_pyruv_trans k59_878899_1 886293.Sinac_7330 4.73e-20 90.5 COG0742@1|root,COG0742@2|Bacteria,2J0PG@203682|Planctomycetes 203682|Planctomycetes L TIGRFAM RNA methyltransferase, RsmD family - - 2.1.1.171 ko:K08316 - - R07234 RC00003 ko00000,ko01000,ko03009 - - - Cons_hypoth95 k59_313829_1 247633.GP2143_13771 1.1e-47 162.0 COG1253@1|root,COG1253@2|Bacteria,1MWT3@1224|Proteobacteria,1RQBC@1236|Gammaproteobacteria,1J8SC@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Domain of unknown function DUF21 - - - - - - - - - - - - CBS,DUF21 k59_1612263_1 1219035.NT2_04_04110 6.83e-17 79.0 COG2885@1|root,COG2885@2|Bacteria,1MYBP@1224|Proteobacteria,2U787@28211|Alphaproteobacteria,2K074@204457|Sphingomonadales 204457|Sphingomonadales M Belongs to the ompA family - - - - - - - - - - - - Gly-zipper_Omp,OmpA k59_1612263_2 158500.BV97_02144 3.91e-23 97.4 COG1253@1|root,COG1253@2|Bacteria,1MV3P@1224|Proteobacteria,2TS80@28211|Alphaproteobacteria,2K087@204457|Sphingomonadales 204457|Sphingomonadales S COG1253 Hemolysins and related proteins containing CBS domains - - - ko:K03699 - - - - ko00000,ko02042 - - - CBS,CorC_HlyC,DUF21 k59_708460_1 1229909.NSED_02140 2.5e-109 322.0 COG1052@1|root,arCOG01755@2157|Archaea,41T1D@651137|Thaumarchaeota 651137|Thaumarchaeota C D-isomer specific 2-hydroxyacid dehydrogenase - - 1.1.1.26 ko:K00015 ko00630,ko01100,ko01110,ko01120,map00630,map01100,map01110,map01120 - R00717,R01388 RC00031,RC00042 ko00000,ko00001,ko01000 - - - 2-Hacid_dh,2-Hacid_dh_C k59_1557176_1 290397.Adeh_0721 1.65e-70 236.0 COG0568@1|root,COG1196@1|root,COG0568@2|Bacteria,COG1196@2|Bacteria,1MVNJ@1224|Proteobacteria,42N2S@68525|delta/epsilon subdivisions,2WJ0E@28221|Deltaproteobacteria,2YUHI@29|Myxococcales 28221|Deltaproteobacteria K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth rpoD - - ko:K03086 - - - - ko00000,ko03021 - - - Sigma70_ner,Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4 k59_255891_1 1121918.ARWE01000001_gene3628 7.76e-34 125.0 COG1893@1|root,COG1893@2|Bacteria,1MX5M@1224|Proteobacteria,42UE5@68525|delta/epsilon subdivisions,2WQDA@28221|Deltaproteobacteria,43W2V@69541|Desulfuromonadales 28221|Deltaproteobacteria H Ketopantoate reductase PanE/ApbA C terminal - - 1.1.1.169 ko:K00077 ko00770,ko01100,ko01110,map00770,map01100,map01110 M00119 R02472 RC00726 ko00000,ko00001,ko00002,ko01000 - - - ApbA,ApbA_C k59_31072_1 1280941.HY2_08810 6.77e-73 226.0 COG1028@1|root,COG1028@2|Bacteria,1MUBQ@1224|Proteobacteria,2TRPN@28211|Alphaproteobacteria,43W99@69657|Hyphomonadaceae 28211|Alphaproteobacteria IQ Belongs to the short-chain dehydrogenases reductases (SDR) family - - - - - - - - - - - - adh_short,adh_short_C2 k59_534550_1 640081.Dsui_0385 9.78e-19 84.3 COG1418@1|root,COG1418@2|Bacteria,1RH6M@1224|Proteobacteria,2VRKW@28216|Betaproteobacteria,2KZQG@206389|Rhodocyclales 206389|Rhodocyclales S mRNA catabolic process - - - - - - - - - - - - - k59_534550_2 314278.NB231_06131 3.46e-30 120.0 COG5009@1|root,COG5009@2|Bacteria,1MU5A@1224|Proteobacteria,1RM7J@1236|Gammaproteobacteria,1WWH1@135613|Chromatiales 135613|Chromatiales M TIGRFAM penicillin-binding protein, 1A - - 2.4.1.129,3.4.16.4 ko:K05366 ko00550,ko01100,ko01501,map00550,map01100,map01501 - - - ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 - PCB_OB,Transgly,Transpeptidase k59_423653_1 1454004.AW11_00689 1.26e-58 200.0 COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,2VH0Y@28216|Betaproteobacteria,1KQS0@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria I 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain fadJ - 1.1.1.157,1.1.1.35,4.2.1.17,5.1.2.3 ko:K00074,ko:K01782 ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00640,ko00650,ko00903,ko00930,ko01040,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00640,map00650,map00903,map00930,map01040,map01100,map01110,map01120,map01130,map01200,map01212 M00032,M00087 R01975,R01976,R03026,R03045,R03276,R04137,R04170,R04203,R04204,R04224,R04737,R04738,R04739,R04740,R04741,R04744,R04745,R04746,R04748,R04749,R05066,R05305,R05576,R06411,R06412,R06941,R06942,R07935,R07951,R08093,R08094 RC00029,RC00099,RC00117,RC00241,RC00525,RC00831,RC00834,RC00896,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 - - - 3HCDH,3HCDH_N,ECH_1 k59_1500330_1 655812.HMPREF0061_0505 2.08e-29 115.0 COG1028@1|root,COG1028@2|Bacteria,1TRQC@1239|Firmicutes,4HD7P@91061|Bacilli 91061|Bacilli IQ Acetoin reductase butA - 1.1.1.304,1.1.1.76 ko:K03366 ko00650,map00650 - R02855,R02946,R03707,R09078,R10505 RC00205,RC00525 ko00000,ko00001,ko01000 - - - adh_short,adh_short_C2 k59_370630_1 999550.KI421507_gene3145 2e-49 168.0 COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,2TQQ7@28211|Alphaproteobacteria 28211|Alphaproteobacteria I Belongs to the thiolase family atoB - 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N k59_370630_2 9601.ENSPPYP00000023949 5.61e-16 78.2 KOG1199@1|root,KOG1199@2759|Eukaryota,38CCA@33154|Opisthokonta,3BD0V@33208|Metazoa,3CY8V@33213|Bilateria,489QM@7711|Chordata,48V3P@7742|Vertebrata,3J98X@40674|Mammalia,35J99@314146|Euarchontoglires,4M88V@9443|Primates,4MSTI@9604|Hominidae 33208|Metazoa Q KR domain HSD17B10 GO:0000003,GO:0000049,GO:0000166,GO:0000959,GO:0000963,GO:0000964,GO:0000965,GO:0000966,GO:0001510,GO:0001540,GO:0002165,GO:0003006,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0003857,GO:0004303,GO:0005102,GO:0005488,GO:0005496,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0005783,GO:0005829,GO:0005886,GO:0006066,GO:0006082,GO:0006139,GO:0006163,GO:0006396,GO:0006399,GO:0006400,GO:0006520,GO:0006629,GO:0006631,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0006996,GO:0007005,GO:0007275,GO:0007548,GO:0007568,GO:0007569,GO:0008033,GO:0008134,GO:0008150,GO:0008152,GO:0008202,GO:0008205,GO:0008209,GO:0008210,GO:0008289,GO:0008406,GO:0008584,GO:0008709,GO:0009056,GO:0009063,GO:0009081,GO:0009083,GO:0009117,GO:0009150,GO:0009259,GO:0009295,GO:0009451,GO:0009791,GO:0009987,GO:0010467,GO:0010817,GO:0012505,GO:0016020,GO:0016043,GO:0016054,GO:0016070,GO:0016125,GO:0016229,GO:0016491,GO:0016614,GO:0016616,GO:0018454,GO:0019637,GO:0019693,GO:0019752,GO:0022414,GO:0022607,GO:0030154,GO:0030283,GO:0030331,GO:0030488,GO:0030677,GO:0030678,GO:0031123,GO:0031974,GO:0032259,GO:0032501,GO:0032502,GO:0032787,GO:0032991,GO:0033218,GO:0033327,GO:0033764,GO:0033865,GO:0033875,GO:0034032,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0034754,GO:0035257,GO:0035258,GO:0035383,GO:0036094,GO:0042180,GO:0042277,GO:0042445,GO:0042645,GO:0042780,GO:0042802,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043412,GO:0043414,GO:0043436,GO:0043603,GO:0043628,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044255,GO:0044260,GO:0044281,GO:0044282,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0045137,GO:0045455,GO:0046395,GO:0046483,GO:0046546,GO:0046661,GO:0047022,GO:0047035,GO:0048037,GO:0048513,GO:0048608,GO:0048731,GO:0048856,GO:0048869,GO:0050662,GO:0051186,GO:0051259,GO:0051260,GO:0051262,GO:0051287,GO:0051289,GO:0051427,GO:0055086,GO:0055114,GO:0061458,GO:0065003,GO:0065007,GO:0065008,GO:0070013,GO:0070525,GO:0070900,GO:0070901,GO:0071704,GO:0071840,GO:0071944,GO:0072521,GO:0090304,GO:0090646,GO:0097159,GO:0097745,GO:0098798,GO:0099116,GO:0140053,GO:1900864,GO:1901135,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901615,GO:1902494,GO:1902555,GO:1902652,GO:1905348,GO:1990180,GO:1990904 1.1.1.178,1.1.1.35 ko:K08683 ko00280,ko01100,ko01110,ko01130,ko05010,map00280,map01100,map01110,map01130,map05010 - R04203 RC00525 ko00000,ko00001,ko01000,ko03029,ko04147 - - - adh_short k59_31086_1 1390370.O203_21160 2.37e-67 238.0 COG2366@1|root,COG2366@2|Bacteria,1MVMH@1224|Proteobacteria,1RPRP@1236|Gammaproteobacteria,1YHTI@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria S Penicillin amidase - - 3.5.1.11 ko:K01434 ko00311,ko01130,map00311,map01130 - R02170 RC00166,RC00328 ko00000,ko00001,ko01000,ko01002 - - - Penicil_amidase k59_142797_1 1392490.JHZX01000001_gene1128 4.76e-57 189.0 COG0457@1|root,COG0457@2|Bacteria,4NG9G@976|Bacteroidetes,1HYXF@117743|Flavobacteriia 976|Bacteroidetes S COG0457 FOG TPR repeat - - - - - - - - - - - - TPR_16,TPR_6,TPR_8 k59_1439662_1 172045.KS04_13300 3.87e-06 50.1 COG3108@1|root,COG3108@2|Bacteria,4NSZA@976|Bacteroidetes,1I46U@117743|Flavobacteriia 976|Bacteroidetes S Peptidase M15 - - - - - - - - - - - - Peptidase_M15_3 k59_1439662_2 266117.Rxyl_1094 1.32e-06 48.9 COG2331@1|root,COG2331@2|Bacteria,2HGE7@201174|Actinobacteria,4CQV7@84995|Rubrobacteria 84995|Rubrobacteria S Regulatory protein, FmdB - - - - - - - - - - - - Zn-ribbon_8 k59_1612295_1 1046714.AMRX01000006_gene2787 1.44e-72 229.0 COG3547@1|root,COG3547@2|Bacteria,1MXKJ@1224|Proteobacteria,1RSCP@1236|Gammaproteobacteria,465IU@72275|Alteromonadaceae 1236|Gammaproteobacteria L Transposase IS116/IS110/IS902 family - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_379114_1 1122137.AQXF01000006_gene778 1.97e-23 97.4 COG1472@1|root,COG1472@2|Bacteria,1MVAJ@1224|Proteobacteria,2TRJK@28211|Alphaproteobacteria 28211|Alphaproteobacteria G beta-N-acetylhexosaminidase nagZ - 3.2.1.21,3.2.1.52 ko:K01207,ko:K05349 ko00460,ko00500,ko00520,ko00531,ko00940,ko01100,ko01110,ko01501,map00460,map00500,map00520,map00531,map00940,map01100,map01110,map01501 M00628 R00022,R00026,R02558,R02887,R02985,R03527,R04949,R04998,R05963,R07809,R07810,R10035,R10039,R10040,R10831 RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248 ko00000,ko00001,ko00002,ko01000 - GH3 - Glyco_hydro_3 k59_379114_2 1122137.AQXF01000006_gene777 7.46e-73 224.0 COG1994@1|root,COG1994@2|Bacteria,1NSFF@1224|Proteobacteria,2TRIF@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Peptidase M50 MA20_27160 - - - - - - - - - - - Peptidase_M50 k59_993841_2 591157.SSLG_05774 1.38e-06 52.4 COG1874@1|root,COG1874@2|Bacteria,2GIUX@201174|Actinobacteria 201174|Actinobacteria G Belongs to the glycosyl hydrolase 35 family - - 3.2.1.23 ko:K12308 ko00052,map00052 - R01105 RC00452 ko00000,ko00001,ko01000 - - - Glyco_hydro_35 k59_1276730_1 316407.85674642 3.97e-124 358.0 COG0583@1|root,COG0583@2|Bacteria,1P293@1224|Proteobacteria,1RNA3@1236|Gammaproteobacteria 1236|Gammaproteobacteria K Transcriptional regulator allS GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0043565,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141 - ko:K10972 - - - - ko00000,ko03000 - - - HTH_1,LysR_substrate k59_1673453_1 1229909.NSED_08475 3.38e-73 223.0 COG3794@1|root,arCOG02926@2157|Archaea,41SPG@651137|Thaumarchaeota 651137|Thaumarchaeota C PFAM Copper binding proteins, plastocyanin azurin family - - - - - - - - - - - - Copper-bind k59_95175_2 765910.MARPU_07330 1.48e-57 184.0 COG0806@1|root,COG0806@2|Bacteria,1MWQR@1224|Proteobacteria,1RNJ2@1236|Gammaproteobacteria,1WY0M@135613|Chromatiales 135613|Chromatiales J An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes rimM - - ko:K02860 - - - - ko00000,ko03009 - - - PRC,RimM k59_768415_1 1408224.SAMCCGM7_c5346 1.66e-50 176.0 COG0402@1|root,COG0402@2|Bacteria,1MUFE@1224|Proteobacteria,2TR3A@28211|Alphaproteobacteria,4BA8M@82115|Rhizobiaceae 28211|Alphaproteobacteria F Cytosine deaminase and related metal-dependent hydrolases hutF - 3.5.3.13 ko:K05603 ko00340,map00340 - R02286 RC00682 ko00000,ko00001,ko01000 - - - Amidohydro_1 k59_1395818_1 1168065.DOK_06010 8.84e-31 119.0 COG1521@1|root,COG1521@2|Bacteria,1MUYA@1224|Proteobacteria,1S99V@1236|Gammaproteobacteria,1J72T@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis coaX - 2.7.1.33 ko:K03525 ko00770,ko01100,map00770,map01100 M00120 R02971,R03018,R04391 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - Pan_kinase k59_1333675_2 1136177.KCA1_2545 0.00022 47.0 COG0110@1|root,COG0110@2|Bacteria,1TSQQ@1239|Firmicutes,4HJJ7@91061|Bacilli,3F73Z@33958|Lactobacillaceae 91061|Bacilli S transferase hexapeptide repeat - - 2.3.1.79 ko:K00661 - - - - ko00000,ko01000 - - - Hexapep,Hexapep_2 k59_993850_1 1278073.MYSTI_01664 2.37e-66 213.0 COG0276@1|root,COG0276@2|Bacteria,1MVR1@1224|Proteobacteria,42M0C@68525|delta/epsilon subdivisions,2WMJ2@28221|Deltaproteobacteria,2YY0V@29|Myxococcales 28221|Deltaproteobacteria H Catalyzes the ferrous insertion into protoporphyrin IX hemH GO:0003674,GO:0003824,GO:0004325,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.99.1.1,4.99.1.9 ko:K01772 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R00310,R11329 RC01012 ko00000,ko00001,ko00002,ko01000 - - - Ferrochelatase k59_1508663_1 391619.PGA1_c01810 4.57e-21 94.7 COG1167@1|root,COG1167@2|Bacteria,1MUJE@1224|Proteobacteria,2TQZZ@28211|Alphaproteobacteria,34FHY@302485|Phaeobacter 28211|Alphaproteobacteria K helix_turn_helix gluconate operon transcriptional repressor - - - - - - - - - - - - Aminotran_1_2,GntR k59_1333677_2 436308.Nmar_0726 6.37e-108 327.0 COG0553@1|root,arCOG00883@2157|Archaea,41T0G@651137|Thaumarchaeota 651137|Thaumarchaeota K SNF2 family N-terminal domain - - - - - - - - - - - - Helicase_C,SNF2_N k59_485925_2 366649.XFF4834R_chr20170 0.000299 45.8 COG0642@1|root,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,1SKTW@1236|Gammaproteobacteria,1X3RD@135614|Xanthomonadales 135614|Xanthomonadales T Histidine kinase rpfC - 2.7.13.3 ko:K10715 ko02020,ko02024,map02020,map02024 M00517 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA,Hpt,Response_reg k59_1619152_1 1117315.AHCA01000001_gene2085 8.07e-35 137.0 COG3866@1|root,COG4677@1|root,COG5276@1|root,COG3866@2|Bacteria,COG4677@2|Bacteria,COG5276@2|Bacteria,1QPFF@1224|Proteobacteria,1RY07@1236|Gammaproteobacteria,2Q456@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria G Amb_all pelB - 4.2.2.2 ko:K01728 ko00040,ko02024,map00040,map02024 - R02361,R06240 RC00049,RC00705 ko00000,ko00001,ko01000 - - - Pec_lyase_C,Pectinesterase k59_149522_1 443152.MDG893_12595 2.12e-88 267.0 COG0682@1|root,COG0682@2|Bacteria,1MVE3@1224|Proteobacteria,1RMVK@1236|Gammaproteobacteria,4655B@72275|Alteromonadaceae 1236|Gammaproteobacteria M Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins lgt GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0008961,GO:0009058,GO:0009059,GO:0009898,GO:0009987,GO:0016020,GO:0016021,GO:0016740,GO:0016757,GO:0019538,GO:0031224,GO:0031226,GO:0034645,GO:0036211,GO:0042157,GO:0042158,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0071704,GO:0071944,GO:0098552,GO:0098562,GO:0140096,GO:1901564,GO:1901566,GO:1901576 - ko:K13292 - - - - ko00000,ko01000 - - - LGT k59_827280_1 760117.JN27_07425 3.65e-13 70.1 COG0589@1|root,COG0589@2|Bacteria,1MZ3K@1224|Proteobacteria,2VU27@28216|Betaproteobacteria,474Q6@75682|Oxalobacteraceae 28216|Betaproteobacteria T Universal stress protein uspA - - - - - - - - - - - Usp k59_604308_1 1283300.ATXB01000001_gene1162 2.93e-80 268.0 COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1145@1|root,COG1146@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1145@2|Bacteria,COG1146@2|Bacteria,1MVM0@1224|Proteobacteria,1RNNX@1236|Gammaproteobacteria,1XE3B@135618|Methylococcales 135618|Methylococcales C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin - - 1.2.7.1 ko:K03737 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00173,M00307 R01196,R10866 RC00004,RC02742 br01601,ko00000,ko00001,ko00002,ko01000 - - - EKR,Fer4_16,PFOR_II,POR,POR_N,TPP_enzyme_C k59_1447212_1 983545.Glaag_3394 1.62e-46 158.0 COG0202@1|root,COG0202@2|Bacteria,1MU75@1224|Proteobacteria,1RMU3@1236|Gammaproteobacteria,464HA@72275|Alteromonadaceae 1236|Gammaproteobacteria K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoA GO:0003674,GO:0003824,GO:0003899,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006354,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576 2.7.7.6 ko:K03040 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_A_CTD,RNA_pol_A_bac,RNA_pol_L k59_1447212_2 34506.g5327 9.5e-18 82.4 COG0097@1|root,COG0098@1|root,COG0099@1|root,COG0100@1|root,COG0200@1|root,COG0522@1|root,KOG0408@2759|Eukaryota,KOG0846@2759|Eukaryota,KOG0877@2759|Eukaryota,KOG3254@2759|Eukaryota,KOG3301@2759|Eukaryota,KOG3311@2759|Eukaryota,3A0A4@33154|Opisthokonta,3BPCP@33208|Metazoa,3D14Y@33213|Bilateria,40D5S@6231|Nematoda,1KVYK@119089|Chromadorea,40TQD@6236|Rhabditida 33208|Metazoa J Ribosomal protein S11 MRPS11 GO:0000028,GO:0000313,GO:0000314,GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0005759,GO:0005761,GO:0005763,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006414,GO:0006415,GO:0006518,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0016070,GO:0016072,GO:0019538,GO:0019843,GO:0019866,GO:0022411,GO:0022607,GO:0022613,GO:0022618,GO:0030490,GO:0031090,GO:0031966,GO:0031967,GO:0031974,GO:0031975,GO:0032543,GO:0032984,GO:0032991,GO:0033554,GO:0034470,GO:0034622,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042255,GO:0042274,GO:0042769,GO:0043043,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046483,GO:0048027,GO:0050896,GO:0051606,GO:0051716,GO:0065003,GO:0070013,GO:0070125,GO:0070126,GO:0070181,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0097159,GO:0098798,GO:0140053,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02948 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S11 k59_1276754_1 1479237.JMLY01000001_gene2037 2.55e-68 223.0 COG0079@1|root,COG0079@2|Bacteria,1MW7I@1224|Proteobacteria,1RP4T@1236|Gammaproteobacteria,464J1@72275|Alteromonadaceae 1236|Gammaproteobacteria E Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily hisC - 2.6.1.9 ko:K00817 ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230 M00026 R00694,R00734,R03243 RC00006,RC00888 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 k59_1108171_1 1117647.M5M_09540 3.72e-61 200.0 COG0439@1|root,COG0439@2|Bacteria,1MU4H@1224|Proteobacteria,1RMNB@1236|Gammaproteobacteria,1J50W@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria I Biotin carboxylase accC GO:0003674,GO:0003824,GO:0004075,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0016053,GO:0016874,GO:0016879,GO:0019216,GO:0019217,GO:0019222,GO:0019752,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032787,GO:0042304,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046394,GO:0046890,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051055,GO:0062012,GO:0062014,GO:0065007,GO:0071704,GO:0072330,GO:0080090,GO:1901576 6.3.4.14,6.4.1.2 ko:K01961 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04385 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 - - iSF_1195.SF3294 Biotin_carb_C,Biotin_carb_N,CPSase_L_D2 k59_1108171_2 1121928.AUHE01000004_gene2558 0.000126 44.7 COG5514@1|root,COG5514@2|Bacteria,2IS68@201174|Actinobacteria,4GFZX@85026|Gordoniaceae 201174|Actinobacteria S Domain of unknown function (DUF1794) - - - - - - - - - - - - DUF1794 k59_541028_1 121225.PHUM304130-PA 8.5e-26 110.0 COG0567@1|root,KOG0450@2759|Eukaryota,38FJ2@33154|Opisthokonta,3BATW@33208|Metazoa,3CU2N@33213|Bilateria,41TXU@6656|Arthropoda,3SHQN@50557|Insecta,3E8A2@33342|Paraneoptera 33208|Metazoa C 2-oxoglutarate dehydrogenase C-terminal OGDHL GO:0003674,GO:0003824,GO:0004591,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005739,GO:0005740,GO:0005759,GO:0005947,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006103,GO:0006104,GO:0006139,GO:0006163,GO:0006464,GO:0006637,GO:0006725,GO:0006732,GO:0006733,GO:0006734,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0006928,GO:0007275,GO:0007399,GO:0007417,GO:0007420,GO:0008150,GO:0008152,GO:0009060,GO:0009117,GO:0009150,GO:0009259,GO:0009353,GO:0009987,GO:0015980,GO:0016020,GO:0016477,GO:0016491,GO:0016620,GO:0016624,GO:0016903,GO:0016999,GO:0017144,GO:0018335,GO:0019362,GO:0019538,GO:0019637,GO:0019674,GO:0019693,GO:0019752,GO:0019842,GO:0021536,GO:0021537,GO:0021543,GO:0021544,GO:0021549,GO:0021695,GO:0021756,GO:0021761,GO:0021766,GO:0021772,GO:0021794,GO:0021859,GO:0021860,GO:0021872,GO:0021879,GO:0021884,GO:0021885,GO:0021953,GO:0021954,GO:0021988,GO:0022008,GO:0022028,GO:0022029,GO:0022037,GO:0030062,GO:0030154,GO:0030182,GO:0030900,GO:0030902,GO:0030976,GO:0031072,GO:0031090,GO:0031966,GO:0031967,GO:0031974,GO:0031975,GO:0032501,GO:0032502,GO:0032991,GO:0033865,GO:0033875,GO:0034032,GO:0034602,GO:0034641,GO:0035383,GO:0036094,GO:0036211,GO:0040011,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043412,GO:0043436,GO:0043543,GO:0043603,GO:0043648,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044281,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0045239,GO:0045240,GO:0045252,GO:0045333,GO:0046483,GO:0046496,GO:0048037,GO:0048468,GO:0048513,GO:0048666,GO:0048699,GO:0048731,GO:0048856,GO:0048869,GO:0048870,GO:0050662,GO:0051087,GO:0051179,GO:0051186,GO:0051674,GO:0055086,GO:0055114,GO:0060322,GO:0061034,GO:0070013,GO:0071704,GO:0072350,GO:0072521,GO:0072524,GO:0097159,GO:0098798,GO:0106077,GO:1901135,GO:1901360,GO:1901363,GO:1901564,GO:1901681,GO:1902494,GO:1990204,GO:1990234 1.2.4.2 ko:K00164 ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00032 R00621,R01933,R01940,R03316,R08549 RC00004,RC00027,RC00627,RC02743,RC02833,RC02883 br01601,ko00000,ko00001,ko00002,ko01000 - - - 2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr k59_1619179_1 930169.B5T_00903 1.66e-48 164.0 COG0720@1|root,COG0720@2|Bacteria,1MXVT@1224|Proteobacteria,1RN6H@1236|Gammaproteobacteria,1XIXT@135619|Oceanospirillales 135619|Oceanospirillales H COG0720 6-pyruvoyl-tetrahydropterin synthase - - - - - - - - - - - - PTPS k59_1619179_2 349521.HCH_05053 3.34e-23 99.8 COG0553@1|root,COG0553@2|Bacteria,1MX6H@1224|Proteobacteria,1RNRZ@1236|Gammaproteobacteria,1XHNQ@135619|Oceanospirillales 135619|Oceanospirillales K Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair rapA - - ko:K03580 - - - - ko00000,ko01000,ko03021 - - - Helicase_C,RapA_C,ResIII,SNF2_N k59_1732815_1 89187.ISM_11630 9e-19 86.3 2BACU@1|root,323T9@2|Bacteria,1R49S@1224|Proteobacteria,2TSC0@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_265397_1 561175.KB894099_gene4997 6.17e-11 67.8 COG4221@1|root,COG4221@2|Bacteria,2GMGQ@201174|Actinobacteria,4EHFC@85012|Streptosporangiales 201174|Actinobacteria S Enoyl-(Acyl carrier protein) reductase sdh GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - - - - - - - - - - adh_short k59_657124_1 861299.J421_0507 8.44e-51 177.0 COG0667@1|root,COG0667@2|Bacteria 2|Bacteria C Aldo Keto reductase - - - ko:K06888 - - - - ko00000 - - - Aldo_ket_red k59_939693_1 1408444.JHYC01000001_gene1210 1.56e-33 134.0 COG1450@1|root,COG1450@2|Bacteria,1MUUA@1224|Proteobacteria,1RPJS@1236|Gammaproteobacteria,1JD7V@118969|Legionellales 118969|Legionellales NU Bacterial type II and III secretion system protein lspD - - ko:K02453 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - SPOR,Secretin,Secretin_N k59_605363_1 436308.Nmar_0672 6.82e-15 72.8 COG0492@1|root,arCOG01296@2157|Archaea,41S97@651137|Thaumarchaeota 651137|Thaumarchaeota O Pyridine nucleotide-disulphide oxidoreductase - - 1.8.1.9 ko:K00384 ko00450,map00450 - R02016,R03596,R09372 RC00013,RC02518,RC02873 ko00000,ko00001,ko01000 - - - Pyr_redox_2 k59_605363_2 436308.Nmar_0671 3.56e-31 115.0 arCOG10533@1|root,arCOG10533@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_1784743_1 83406.HDN1F_19300 1.08e-35 130.0 COG3332@1|root,COG3332@2|Bacteria,1RDBS@1224|Proteobacteria,1S43Y@1236|Gammaproteobacteria,1J6C9@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Transport and Golgi organisation 2 - - - - - - - - - - - - TANGO2 k59_40533_1 316407.85674618 5.56e-112 331.0 COG2223@1|root,COG2223@2|Bacteria,1MXAA@1224|Proteobacteria,1RMZZ@1236|Gammaproteobacteria,3XP1S@561|Escherichia 1236|Gammaproteobacteria P Fosmidomycin resistance protein fsr GO:0005575,GO:0005623,GO:0005886,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0016020,GO:0033554,GO:0042221,GO:0044464,GO:0046677,GO:0050896,GO:0051716,GO:0071944 - ko:K08223 - - - - ko00000,ko02000 2.A.1.35 - - MFS_1 k59_718440_1 436308.Nmar_0672 1.09e-124 362.0 COG0492@1|root,arCOG01296@2157|Archaea,41S97@651137|Thaumarchaeota 651137|Thaumarchaeota O Pyridine nucleotide-disulphide oxidoreductase - - 1.8.1.9 ko:K00384 ko00450,map00450 - R02016,R03596,R09372 RC00013,RC02518,RC02873 ko00000,ko00001,ko01000 - - - Pyr_redox_2 k59_1732844_1 1484460.JSWG01000012_gene1505 1.45e-109 335.0 COG0358@1|root,COG0358@2|Bacteria,4NENT@976|Bacteroidetes,1HWVC@117743|Flavobacteriia 976|Bacteroidetes L RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication dnaG - - ko:K02316 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB_bind,Toprim_2,Toprim_4,Toprim_N,zf-CHC2 k59_1056813_1 95619.PM1_0216575 2.37e-66 209.0 COG0336@1|root,COG0336@2|Bacteria,1MUN1@1224|Proteobacteria,1RMWC@1236|Gammaproteobacteria 1236|Gammaproteobacteria J Belongs to the RNA methyltransferase TrmD family trmD GO:0000287,GO:0001510,GO:0002939,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009019,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0016772,GO:0016779,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0050518,GO:0052906,GO:0070567,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.1.1.228 ko:K00554 - - R00597 RC00003,RC00334 ko00000,ko01000,ko03016 - - - tRNA_m1G_MT k59_1784764_1 1229909.NSED_07280 1.41e-68 213.0 COG0638@1|root,arCOG00971@2157|Archaea,41SYA@651137|Thaumarchaeota 651137|Thaumarchaeota O Proteasome endopeptidase complex - - 3.4.25.1 ko:K03432 ko03050,map03050 M00342,M00343 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03051 - - - Proteasome,Proteasome_A_N k59_1509849_1 1045855.DSC_02675 3.45e-75 252.0 COG0046@1|root,COG0047@1|root,COG0046@2|Bacteria,COG0047@2|Bacteria,1MYN4@1224|Proteobacteria,1RMRN@1236|Gammaproteobacteria,1X32J@135614|Xanthomonadales 135614|Xanthomonadales F Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate purL GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 6.3.5.3 ko:K01952 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04463 RC00010,RC01160 ko00000,ko00001,ko00002,ko01000 - - - AIRS_C,GATase_5 k59_1674562_2 1123322.KB904692_gene4472 2.07e-16 76.3 COG0748@1|root,COG0748@2|Bacteria,2I31I@201174|Actinobacteria 201174|Actinobacteria P Pyridoxamine 5'-phosphate oxidase - - - - - - - - - - - - Putative_PNPOx k59_40554_1 1229909.NSED_00120 5.8e-164 466.0 COG0192@1|root,arCOG07444@2157|Archaea,41S5P@651137|Thaumarchaeota 651137|Thaumarchaeota H S-adenosylmethionine synthetase - - 2.5.1.6 ko:K00789 ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230 M00034,M00035,M00368,M00609 R00177,R04771 RC00021,RC01211 ko00000,ko00001,ko00002,ko01000 - - - S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N k59_605382_1 1123253.AUBD01000001_gene1873 4.75e-87 268.0 COG1294@1|root,COG1294@2|Bacteria,1MURP@1224|Proteobacteria,1RN0N@1236|Gammaproteobacteria,1X35A@135614|Xanthomonadales 135614|Xanthomonadales C oxidase, subunit II - - - - - - - - - - - - Cyt_bd_oxida_II k59_1567343_1 313598.MED152_08150 2.38e-44 151.0 COG0328@1|root,COG3341@1|root,COG0328@2|Bacteria,COG3341@2|Bacteria,4NI01@976|Bacteroidetes,1HXD6@117743|Flavobacteriia,3VVH3@52959|Polaribacter 976|Bacteroidetes L RNase H rnhA - 3.1.26.4 ko:K03469 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - Cauli_VI,RNase_H k59_769495_1 1088721.NSU_0459 1.13e-18 90.1 COG0477@1|root,COG2814@2|Bacteria,1NU31@1224|Proteobacteria,2U65J@28211|Alphaproteobacteria,2K9A1@204457|Sphingomonadales 204457|Sphingomonadales EGP Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 k59_1334788_1 316407.4062469 2.17e-118 349.0 COG2256@1|root,COG2256@2|Bacteria,1MUVS@1224|Proteobacteria,1RPBY@1236|Gammaproteobacteria,3XM8Q@561|Escherichia 1236|Gammaproteobacteria L DNA-dependent ATPase that plays important roles in cellular responses to stalled DNA replication processes rarA GO:0005575,GO:0005622,GO:0005623,GO:0005657,GO:0005694,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006310,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0030894,GO:0032991,GO:0032993,GO:0034641,GO:0034645,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044422,GO:0044424,GO:0044427,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901576 - ko:K07478 - - - - ko00000 - - - AAA,AAA_assoc_2,MgsA_C,RuvB_N k59_96304_1 28444.JODQ01000003_gene5042 3.5e-33 125.0 COG3508@1|root,COG3508@2|Bacteria,2GKZV@201174|Actinobacteria,4EHDH@85012|Streptosporangiales 201174|Actinobacteria Q homogentisate 1,2-dioxygenase - - 1.13.11.5 ko:K00451 ko00350,ko00643,ko01100,ko01120,map00350,map00643,map01100,map01120 M00044 R02519 RC00737 ko00000,ko00001,ko00002,ko01000 - - - HgmA k59_96304_2 195250.CM001776_gene898 8.45e-14 76.3 COG0124@1|root,COG0124@2|Bacteria,1G218@1117|Cyanobacteria 1117|Cyanobacteria J histidyl-tRNA synthetase - - - - - - - - - - - - - k59_1056833_1 1370125.AUWT01000020_gene4656 3.36e-35 129.0 2D663@1|root,32TKM@2|Bacteria,2I9AK@201174|Actinobacteria,23536@1762|Mycobacteriaceae 201174|Actinobacteria - - - - - - - - - - - - - - - k59_1056837_1 1123355.JHYO01000014_gene1039 1.14e-05 50.8 COG3243@1|root,COG3243@2|Bacteria,1MU68@1224|Proteobacteria,2TR7S@28211|Alphaproteobacteria,36XN8@31993|Methylocystaceae 28211|Alphaproteobacteria I Poly-beta-hydroxybutyrate polymerase N terminal phbC - - ko:K03821 ko00650,map00650 - R04254 RC00004 ko00000,ko00001,ko01000 - - - PHBC_N,PhaC_N k59_1784805_1 702113.PP1Y_AT7076 1.33e-46 155.0 COG0745@1|root,COG0745@2|Bacteria,1NR4N@1224|Proteobacteria,2UPPS@28211|Alphaproteobacteria,2K4BM@204457|Sphingomonadales 204457|Sphingomonadales T Regulator - - - ko:K07657 ko02020,map02020 M00434 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Trans_reg_C k59_323760_1 1144305.PMI02_03727 7.02e-26 112.0 COG1629@1|root,COG4771@2|Bacteria,1MVFB@1224|Proteobacteria,2U2UJ@28211|Alphaproteobacteria,2KEDN@204457|Sphingomonadales 204457|Sphingomonadales P TonB-dependent receptor plug - - - - - - - - - - - - Plug,TonB_dep_Rec k59_995033_1 338963.Pcar_1619 4.1e-25 104.0 COG1022@1|root,COG1022@2|Bacteria,1MU4D@1224|Proteobacteria,42N2G@68525|delta/epsilon subdivisions,2WIXB@28221|Deltaproteobacteria,43TKN@69541|Desulfuromonadales 28221|Deltaproteobacteria I AMP-binding enzyme - - 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding,AMP-binding_C k59_995033_2 1121097.JCM15093_1198 0.000598 43.1 COG2768@1|root,COG2768@2|Bacteria 2|Bacteria - - - - 1.12.7.2 ko:K00533,ko:K03616 - - R00019 - ko00000,ko01000 - - - FeS,Fe_hyd_SSU,Fe_hyd_lg_C,Fer4,Fer4_9,MCPsignal,Nitroreductase k59_1334811_1 1121459.AQXE01000014_gene397 7.54e-29 111.0 COG0241@1|root,COG0241@2|Bacteria,1RDGR@1224|Proteobacteria,42SCB@68525|delta/epsilon subdivisions,2WPEA@28221|Deltaproteobacteria,2MBDI@213115|Desulfovibrionales 28221|Deltaproteobacteria E hydrolase, HAD-superfamily, subfamily IIIA gmhB - 3.1.3.82,3.1.3.83 ko:K03273 ko00540,ko01100,map00540,map01100 M00064 R05647,R09771 RC00017 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Hydrolase_like k59_1334811_2 269799.Gmet_1915 3.2e-10 66.2 COG0658@1|root,COG2333@1|root,COG0658@2|Bacteria,COG2333@2|Bacteria,1MUKF@1224|Proteobacteria,42N3S@68525|delta/epsilon subdivisions,2WJ5P@28221|Deltaproteobacteria,43TMI@69541|Desulfuromonadales 28221|Deltaproteobacteria S TIGRFAM DNA internalization-related competence protein ComEC Rec2 - - - ko:K02238 - M00429 - - ko00000,ko00002,ko02044 3.A.11.1,3.A.11.2 - - Competence,DUF4131,Lactamase_B k59_888706_1 314278.NB231_01154 6.36e-15 73.9 COG1381@1|root,COG1381@2|Bacteria,1RHIC@1224|Proteobacteria,1RN8Y@1236|Gammaproteobacteria,1WY02@135613|Chromatiales 135613|Chromatiales L Involved in DNA repair and RecF pathway recombination recO - - ko:K03584 ko03440,map03440 - - - ko00000,ko00001,ko03400 - - - RecO_C,RecO_N k59_888706_2 868595.Desca_1867 7.71e-22 94.0 COG1159@1|root,COG1159@2|Bacteria,1TP3R@1239|Firmicutes,24876@186801|Clostridia,2609D@186807|Peptococcaceae 186801|Clostridia S An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism era - - ko:K03595 - - - - ko00000,ko03009,ko03029 - - - KH_2,MMR_HSR1 k59_1396804_1 2754.EH55_02430 2.28e-08 58.2 COG0297@1|root,COG0297@2|Bacteria,3TAAG@508458|Synergistetes 508458|Synergistetes G Synthesizes alpha-1,4-glucan chains using ADP-glucose glgA - 2.4.1.21 ko:K00703 ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026 M00565 R02421 RC00005 ko00000,ko00001,ko00002,ko01000,ko01003 - GT5 - Glyco_transf_5,Glycos_transf_1 k59_1396804_2 1266925.JHVX01000003_gene414 4.63e-15 76.3 COG0058@1|root,COG0058@2|Bacteria,1MW4J@1224|Proteobacteria,2VM4W@28216|Betaproteobacteria,372UR@32003|Nitrosomonadales 28216|Betaproteobacteria G PFAM glycosyl transferase, family 35 - - 2.4.1.1 ko:K00688 ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931 - R02111 - ko00000,ko00001,ko01000 - GT35 - DUF3417,Phosphorylase k59_718490_1 1144305.PMI02_01712 3.69e-56 191.0 COG2939@1|root,COG2939@2|Bacteria,1MW05@1224|Proteobacteria,2TS7R@28211|Alphaproteobacteria,2K0U5@204457|Sphingomonadales 204457|Sphingomonadales E peptidase S10 serine carboxypeptidase - - - - - - - - - - - - Peptidase_S10 k59_96323_1 1123242.JH636435_gene2912 7.44e-27 110.0 29NDR@1|root,309BM@2|Bacteria,2IZC5@203682|Planctomycetes 203682|Planctomycetes - - - - - - - - - - - - - - - k59_40608_1 1057002.KB905370_gene3672 2.99e-37 145.0 COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,2TRWM@28211|Alphaproteobacteria,4BB6Z@82115|Rhizobiaceae 28211|Alphaproteobacteria P cation efflux system protein (Heavy metal efflux pump) - - - - - - - - - - - - ACR_tran k59_605439_1 398767.Glov_1062 1.29e-29 121.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,42M0W@68525|delta/epsilon subdivisions,2WIK8@28221|Deltaproteobacteria,43TNR@69541|Desulfuromonadales 28221|Deltaproteobacteria T GGDEF domain containing protein - - - - - - - - - - - - CHASE4,EAL,GAF_2,GGDEF,PAS,PAS_3,PAS_4,PAS_9,Response_reg,dCache_1 k59_1056871_1 243924.LT42_19885 7.15e-10 62.4 COG3079@1|root,COG3079@2|Bacteria 2|Bacteria S Belongs to the UPF0149 family ygfB GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - ko:K09895 - - - - ko00000 - - - UPF0149 k59_1509912_1 671143.DAMO_1178 2.03e-05 47.0 COG3677@1|root,COG3677@2|Bacteria 2|Bacteria L transposition, DNA-mediated - - - - - - - - - - - - DDE_Tnp_IS1595,Zn_Tnp_IS1595 k59_1509912_2 1408224.SAMCCGM7_c6671 5.42e-12 67.0 COG3677@1|root,COG3677@2|Bacteria,1MXYX@1224|Proteobacteria,2TQR3@28211|Alphaproteobacteria,4BFF2@82115|Rhizobiaceae 28211|Alphaproteobacteria L ISXO2-like transposase domain - - - - - - - - - - - - DDE_Tnp_IS1595,Zn_Tnp_IS1595 k59_323778_1 436308.Nmar_0783 1.43e-40 137.0 arCOG10549@1|root,arCOG10549@2157|Archaea,41STE@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_323778_2 436308.Nmar_0782 5.79e-59 183.0 COG2343@1|root,arCOG06569@2157|Archaea 2157|Archaea S Domain of unknown function (DUF427) - - - - - - - - - - - - NTP_transf_9 k59_323778_3 1229909.NSED_06365 2.3e-58 192.0 arCOG08038@1|root,arCOG08643@1|root,arCOG08038@2157|Archaea,arCOG08643@2157|Archaea 2157|Archaea S peptidyl-tyrosine sulfation - - - - - - - - - - - - - k59_888734_1 1166948.JPZL01000001_gene2360 4.88e-34 130.0 COG1199@1|root,COG1199@2|Bacteria,1MVCU@1224|Proteobacteria,1RMNX@1236|Gammaproteobacteria,1XIVR@135619|Oceanospirillales 135619|Oceanospirillales KL helicase dinG - 3.6.4.12 ko:K03722 - - - - ko00000,ko01000,ko03400 - - - DEAD,DEAD_2,Helicase_C_2,ResIII k59_265496_1 555079.Toce_1665 2.25e-39 144.0 COG3547@1|root,COG3547@2|Bacteria,1TQP6@1239|Firmicutes,248VD@186801|Clostridia,42FT8@68295|Thermoanaerobacterales 186801|Clostridia L Transposase IS116 IS110 IS902 family protein - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_1056891_1 436308.Nmar_0101 1.7e-128 385.0 COG0464@1|root,arCOG01308@2157|Archaea,41SB6@651137|Thaumarchaeota 651137|Thaumarchaeota O Cell division protein 48 (CDC48), domain 2 - - - ko:K13525 ko04141,ko05134,map04141,map05134 M00400,M00403 - - ko00000,ko00001,ko00002,ko03019,ko04131,ko04147 3.A.16.1 - - AAA,CDC48_2,CDC48_N k59_891014_2 199310.c4346 1.28e-89 267.0 COG1192@1|root,COG1192@2|Bacteria,1MXFI@1224|Proteobacteria,1RYAG@1236|Gammaproteobacteria,3XMY2@561|Escherichia 1236|Gammaproteobacteria D Cellulose biosynthesis protein BcsQ yhjQ - - - - - - - - - - - CBP_BcsQ k59_1337089_1 13690.CP98_03720 7.03e-20 87.0 COG0207@1|root,COG0207@2|Bacteria,1MUBD@1224|Proteobacteria,2TQSB@28211|Alphaproteobacteria,2K0PF@204457|Sphingomonadales 204457|Sphingomonadales F Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis thyA - 2.1.1.45 ko:K00560 ko00240,ko00670,ko01100,ko01523,map00240,map00670,map01100,map01523 M00053 R02101 RC00219,RC00332 ko00000,ko00001,ko00002,ko01000 - - - Thymidylat_synt k59_1337089_2 648885.KB316283_gene3815 2.34e-53 173.0 COG0262@1|root,COG0262@2|Bacteria,1RH0P@1224|Proteobacteria,2U9GC@28211|Alphaproteobacteria,1JSUP@119045|Methylobacteriaceae 28211|Alphaproteobacteria H Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis folA - 1.5.1.3 ko:K00287 ko00670,ko00790,ko01100,ko01523,map00670,map00790,map01100,map01523 M00126,M00840 R00936,R00937,R00939,R00940,R02235,R02236,R11765 RC00109,RC00110,RC00158 ko00000,ko00001,ko00002,ko01000 - - - DHFR_1 k59_268007_1 199310.c4336 9.83e-32 116.0 COG2200@1|root,COG2200@2|Bacteria,1N1RI@1224|Proteobacteria,1RQ03@1236|Gammaproteobacteria,3XMQ2@561|Escherichia 1236|Gammaproteobacteria T A bis-(3'-5') cyclic diguanylic acid (c-di-GMP) phosphodiesterase involved in regulating the levels of c-di-GMP that control cell motility (the flagella) and adhesion (adhesive curli fimbriae). The YhjH effect on flagella is controlled via the c-di-GMP-binding flagellar brake protein YcgR, however curli expression is not regulated via YcgR. Forms a network with different diguanylate cyclases (DosC, YeaJ, YedQ, YegE have been identified) to regulate c-di-GMP levels. Flagellar activity is high at low c-di-GMP levels whereas curli fimbria are induced at high c-di-GMP levels. Cyclic-di-GMP is a second messenger which controls cell surface-associated traits in bacteria yhjH GO:0003674,GO:0003824,GO:0008081,GO:0008150,GO:0016787,GO:0016788,GO:0032879,GO:0040012,GO:0042578,GO:0050789,GO:0050794,GO:0051270,GO:0065007,GO:0071111,GO:1902021,GO:2000145 3.1.4.52 ko:K21086 ko02026,map02026 - - - ko00000,ko00001,ko01000 - - - EAL k59_268007_2 316407.85676520 2.27e-91 285.0 COG2982@1|root,COG2982@2|Bacteria,1MUAN@1224|Proteobacteria,1RNZM@1236|Gammaproteobacteria,3XN25@561|Escherichia 1236|Gammaproteobacteria M regulation of protein targeting yhjG GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0032386,GO:0032879,GO:0032880,GO:0033157,GO:0044464,GO:0050789,GO:0051049,GO:0051223,GO:0060341,GO:0065007,GO:0070201,GO:0071944,GO:0090087,GO:0090313,GO:1903533,GO:1903827,GO:1905475 - ko:K07290 - - - - ko00000 9.B.121 - - AsmA k59_489666_1 717772.THIAE_10465 6.23e-57 199.0 COG0187@1|root,COG0187@2|Bacteria,1MVKT@1224|Proteobacteria,1RNB2@1236|Gammaproteobacteria,45ZT1@72273|Thiotrichales 72273|Thiotrichales L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrB - 5.99.1.3 ko:K02470 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim k59_891017_1 436308.Nmar_1288 1.41e-46 157.0 COG0189@1|root,arCOG01589@2157|Archaea,41SCQ@651137|Thaumarchaeota 651137|Thaumarchaeota H Lysine biosynthesis - - 6.3.2.43 ko:K05827 ko00300,ko01100,ko01210,ko01230,map00300,map01100,map01210,map01230 M00031 R09775 RC00064,RC00090 ko00000,ko00001,ko00002,ko01000 - - - RimK k59_891017_2 436308.Nmar_1287 1.43e-30 107.0 arCOG01588@1|root,arCOG01588@2157|Archaea,41SVX@651137|Thaumarchaeota 651137|Thaumarchaeota E lysine biosynthesis protein LysW - - - ko:K05826 - M00031,M00763 - - ko00000,ko00001,ko00002 - - - - k59_891017_3 436308.Nmar_1286 1.29e-19 86.7 COG0137@1|root,arCOG00112@2157|Archaea,41S6K@651137|Thaumarchaeota 651137|Thaumarchaeota E Belongs to the argininosuccinate synthase family. Type 1 subfamily argG - 6.3.4.5 ko:K01940 ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418 M00029,M00844,M00845 R01954 RC00380,RC00629 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Arginosuc_synth k59_152989_1 522306.CAP2UW1_4182 1.43e-91 278.0 COG0232@1|root,COG0232@2|Bacteria,1MVQ2@1224|Proteobacteria,2VI7B@28216|Betaproteobacteria,1KPTA@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria F Belongs to the dGTPase family. Type 2 subfamily dgt - 3.1.5.1 ko:K01129 ko00230,map00230 - R01856 RC00017 ko00000,ko00001,ko01000 - - - HD,HD_assoc k59_42814_1 76114.ebA2728 5.27e-11 64.3 COG0484@1|root,COG0484@2|Bacteria,1MUZ4@1224|Proteobacteria,2VHMU@28216|Betaproteobacteria,2KVDG@206389|Rhodocyclales 206389|Rhodocyclales O DnaJ molecular chaperone homology domain - - - ko:K05516 - - - - ko00000,ko03036,ko03110 - - - DnaJ,DnaJ_C k59_42814_3 1380390.JIAT01000009_gene1007 3.6e-33 123.0 COG3001@1|root,COG3001@2|Bacteria,2GW7W@201174|Actinobacteria,4CQEA@84995|Rubrobacteria 84995|Rubrobacteria G Fructosamine kinase - - - - - - - - - - - - Fructosamin_kin k59_544801_1 1192034.CAP_2100 1.11e-08 55.5 COG0531@1|root,COG0531@2|Bacteria,1MUA2@1224|Proteobacteria,42T8N@68525|delta/epsilon subdivisions,2WZ91@28221|Deltaproteobacteria,2Z1M2@29|Myxococcales 28221|Deltaproteobacteria E Amino acid permease - - - - - - - - - - - - AA_permease_2 k59_544801_2 1215114.BBIU01000011_gene1764 1.02e-78 251.0 COG3930@1|root,COG3930@2|Bacteria,1PYFH@1224|Proteobacteria,1RP1J@1236|Gammaproteobacteria 1236|Gammaproteobacteria S protein conserved in bacteria IV02_27630 - - - - - - - - - - - DUF1704 k59_326113_1 1122137.AQXF01000002_gene166 9.29e-157 449.0 COG0022@1|root,COG0022@2|Bacteria,1R8KB@1224|Proteobacteria,2TRMR@28211|Alphaproteobacteria 28211|Alphaproteobacteria C The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) pdhB - 1.2.4.1 ko:K00162 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230 M00307 R00014,R00209,R01699,R03270 RC00004,RC00027,RC00627,RC02742,RC02744,RC02882 br01601,ko00000,ko00001,ko00002,ko01000 - - - Biotin_lipoyl,Transket_pyr,Transketolase_C k59_382744_1 395965.Msil_3633 2.76e-47 156.0 COG2197@1|root,COG2197@2|Bacteria,1RCCE@1224|Proteobacteria,2U6U1@28211|Alphaproteobacteria,3NB1N@45404|Beijerinckiaceae 28211|Alphaproteobacteria T cheY-homologous receiver domain - - - - - - - - - - - - Response_reg k59_1170979_2 316407.85675088 3.92e-36 124.0 COG0292@1|root,COG0292@2|Bacteria,1RGU2@1224|Proteobacteria,1S3P3@1236|Gammaproteobacteria,3XPR3@561|Escherichia 1236|Gammaproteobacteria J Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit rplT GO:0000027,GO:0000900,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006355,GO:0006412,GO:0006417,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015934,GO:0016043,GO:0017148,GO:0019219,GO:0019222,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030371,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0045182,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0051252,GO:0060255,GO:0065003,GO:0065007,GO:0070180,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0080090,GO:0090079,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903506,GO:1990904,GO:2000112,GO:2000113,GO:2001141 - ko:K02887 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L20 k59_1280567_1 349124.Hhal_2121 6.54e-65 209.0 COG0517@1|root,COG0794@1|root,COG0517@2|Bacteria,COG0794@2|Bacteria,1MUXD@1224|Proteobacteria,1RMT9@1236|Gammaproteobacteria,1WWFJ@135613|Chromatiales 135613|Chromatiales M Arabinose 5-phosphate isomerase - - 5.3.1.13 ko:K06041 ko00540,ko01100,map00540,map01100 M00063 R01530 RC00541 ko00000,ko00001,ko00002,ko01000,ko01005 - - - CBS,SIS k59_210463_1 391616.OA238_c43530 2.12e-31 127.0 COG1404@1|root,COG1404@2|Bacteria,1RCVP@1224|Proteobacteria,2UK1F@28211|Alphaproteobacteria 28211|Alphaproteobacteria MO outer membrane autotransporter barrel domain protein - - - - - - - - - - - - - k59_1227006_1 876044.IMCC3088_33 3e-90 276.0 COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,1RV50@1236|Gammaproteobacteria,1J92K@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria I Beta-ketoacyl synthase, N-terminal domain fadA - 2.3.1.16,2.3.1.9 ko:K00626,ko:K00632 ko00071,ko00072,ko00280,ko00281,ko00310,ko00362,ko00380,ko00592,ko00620,ko00630,ko00640,ko00642,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00281,map00310,map00362,map00380,map00592,map00620,map00630,map00640,map00642,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00087,M00088,M00095,M00113,M00373,M00374,M00375 R00238,R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095 RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N k59_1787271_1 926569.ANT_01950 4.08e-73 236.0 COG0154@1|root,COG0154@2|Bacteria,2G5T0@200795|Chloroflexi 2|Bacteria J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) gatA - 6.3.5.6,6.3.5.7 ko:K02433 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - Amidase k59_1677252_1 1122225.AULQ01000005_gene2410 1.26e-48 177.0 COG3291@1|root,COG3291@2|Bacteria,4NDZQ@976|Bacteroidetes,1HX5A@117743|Flavobacteriia 976|Bacteroidetes M C-terminal domain of CHU protein family - - - - - - - - - - - - CHU_C,CUB,HYR,PKD,P_proprotein,SprB k59_607715_1 1230476.C207_05513 9.69e-48 166.0 COG3239@1|root,COG3239@2|Bacteria,1MUHK@1224|Proteobacteria,2TSTR@28211|Alphaproteobacteria,3JTTJ@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria I Fatty acid desaturase MA20_28095 - - - - - - - - - - - FA_desaturase k59_42832_1 236097.ADG881_1577 2.76e-29 116.0 COG0845@1|root,COG0845@2|Bacteria,1MU78@1224|Proteobacteria,1RPI1@1236|Gammaproteobacteria,1XHAQ@135619|Oceanospirillales 135619|Oceanospirillales M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - ko:K03585 ko01501,ko01503,map01501,map01503 M00646,M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000,ko03036 2.A.6.2,8.A.1.6 - - HlyD_D23 k59_1171885_1 1134474.O59_001099 3.76e-57 182.0 COG1047@1|root,COG1047@2|Bacteria,1RHD1@1224|Proteobacteria,1S5YP@1236|Gammaproteobacteria,1FGEX@10|Cellvibrio 1236|Gammaproteobacteria O FKBP-type peptidyl-prolyl cis-trans isomerase fkpB GO:0000413,GO:0003674,GO:0003755,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016853,GO:0016859,GO:0018193,GO:0018208,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0061077,GO:0071704,GO:0140096,GO:1901564 5.2.1.8 ko:K03774 - - - - ko00000,ko01000,ko03110 - - - FKBP_C k59_1171885_2 1217718.ALOU01000046_gene4048 2.25e-55 179.0 COG0597@1|root,COG0597@2|Bacteria,1RGV9@1224|Proteobacteria,2VSEP@28216|Betaproteobacteria,1K1IQ@119060|Burkholderiaceae 28216|Betaproteobacteria MU This protein specifically catalyzes the removal of signal peptides from prolipoproteins lspA - 3.4.23.36 ko:K03101 ko03060,map03060 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_A8 k59_268952_1 1521187.JPIM01000028_gene1610 5.9e-63 205.0 COG4608@1|root,COG4608@2|Bacteria,2G5R5@200795|Chloroflexi,3750H@32061|Chloroflexia 32061|Chloroflexia P Belongs to the ABC transporter superfamily - - - ko:K02032,ko:K10823 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00239,M00439 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 - - ABC_tran,oligo_HPY k59_1112883_2 1122137.AQXF01000001_gene2608 6.31e-134 382.0 COG1802@1|root,COG1802@2|Bacteria,1RFKQ@1224|Proteobacteria 1224|Proteobacteria K FCD domain - - - - - - - - - - - - FCD,GntR k59_661310_2 1278309.KB907107_gene1737 2.54e-20 90.5 COG1344@1|root,COG1344@2|Bacteria,1MV1N@1224|Proteobacteria,1RN0Y@1236|Gammaproteobacteria,1XHU8@135619|Oceanospirillales 135619|Oceanospirillales N Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella - - - ko:K02406 ko02020,ko02040,ko04621,ko04626,ko05132,ko05134,map02020,map02040,map04621,map04626,map05132,map05134 - - - ko00000,ko00001,ko02035 - - - Flagellin_C,Flagellin_N k59_1171903_1 926550.CLDAP_10860 5.25e-55 181.0 COG0627@1|root,COG0627@2|Bacteria,2G76X@200795|Chloroflexi 200795|Chloroflexi S Putative esterase - - - - - - - - - - - - Esterase k59_891991_1 1123399.AQVE01000011_gene1257 4.92e-31 123.0 COG2957@1|root,COG2957@2|Bacteria,1MX65@1224|Proteobacteria,1RMF1@1236|Gammaproteobacteria,461WP@72273|Thiotrichales 72273|Thiotrichales E Porphyromonas-type peptidyl-arginine deiminase - - - - - - - - - - - - PAD_porph k59_1112895_2 998674.ATTE01000001_gene600 1.76e-86 260.0 COG0207@1|root,COG0207@2|Bacteria,1MUBD@1224|Proteobacteria,1RPYV@1236|Gammaproteobacteria,45ZPG@72273|Thiotrichales 72273|Thiotrichales F Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis thyA - 2.1.1.45 ko:K00560 ko00240,ko00670,ko01100,ko01523,map00240,map00670,map01100,map01523 M00053 R02101 RC00219,RC00332 ko00000,ko00001,ko00002,ko01000 - - - Thymidylat_synt k59_608678_1 1123487.KB892865_gene1375 1.53e-97 294.0 28MVD@1|root,2ZB2Y@2|Bacteria,1R8NK@1224|Proteobacteria,2VPRP@28216|Betaproteobacteria,2KZJK@206389|Rhodocyclales 206389|Rhodocyclales S Protein of unknown function (DUF4043) - - - - - - - - - - - - DUF4043 k59_1060083_1 522306.CAP2UW1_2148 1.94e-69 221.0 COG2378@1|root,COG2378@2|Bacteria,1P2ZE@1224|Proteobacteria,2VMDI@28216|Betaproteobacteria,1KQ7Z@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria K WYL domain - - - - - - - - - - - - HTH_11,WYL k59_211308_1 552811.Dehly_1092 3.58e-29 108.0 COG0091@1|root,COG0091@2|Bacteria,2G6ZQ@200795|Chloroflexi,34DE4@301297|Dehalococcoidia 301297|Dehalococcoidia J The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome rplV - - ko:K02890 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L22 k59_211308_2 1220589.CD32_05025 7.55e-10 57.8 COG0092@1|root,COG0092@2|Bacteria,1TPCP@1239|Firmicutes,4HAUR@91061|Bacilli,3IWEF@400634|Lysinibacillus 91061|Bacilli J Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation rpsC GO:0002181,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02982 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - KH_2,Ribosomal_S3_C k59_154091_1 211165.AJLN01000149_gene6689 4.56e-21 100.0 COG1520@1|root,COG3209@1|root,COG3291@1|root,COG1520@2|Bacteria,COG3209@2|Bacteria,COG3291@2|Bacteria,1GR04@1117|Cyanobacteria,1JKRU@1189|Stigonemataceae 1117|Cyanobacteria M Bacterial pre-peptidase C-terminal domain - - - - - - - - - - - - PPC k59_490634_1 247633.GP2143_13281 4.55e-14 71.2 COG2267@1|root,COG2267@2|Bacteria,1QTAP@1224|Proteobacteria,1SEI7@1236|Gammaproteobacteria,1J802@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria I Alpha/beta hydrolase family - - - - - - - - - - - - Abhydrolase_1 k59_490634_2 1229204.AMYY01000009_gene1891 1.22e-61 214.0 COG1228@1|root,COG1228@2|Bacteria,1MXQX@1224|Proteobacteria,2U1V8@28211|Alphaproteobacteria 28211|Alphaproteobacteria Q overlaps another CDS with the same product name - - - - - - - - - - - - Amidohydro_1,Amidohydro_3 k59_942927_1 436308.Nmar_0697 3.41e-69 210.0 COG0229@1|root,arCOG02815@2157|Archaea,41SMK@651137|Thaumarchaeota 651137|Thaumarchaeota O Belongs to the MsrB Met sulfoxide reductase family msrB - 1.8.4.12 ko:K07305 - - - - ko00000,ko01000 - - - SelR k59_942927_2 1229909.NSED_03605 1.25e-15 74.7 COG0460@1|root,arCOG01351@2157|Archaea,41SAC@651137|Thaumarchaeota 651137|Thaumarchaeota E homoserine dehydrogenase - - 1.1.1.3 ko:K00003 ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230 M00017,M00018 R01773,R01775 RC00087 ko00000,ko00001,ko00002,ko01000 - - - Homoserine_dh,NAD_binding_3 k59_1227849_1 180281.CPCC7001_790 2.64e-12 70.1 COG1376@1|root,COG1376@2|Bacteria,1GDS1@1117|Cyanobacteria,22SPY@167375|Cyanobium 1117|Cyanobacteria S L,D-transpeptidase catalytic domain - - - - - - - - - - - - YkuD k59_831668_1 1229909.NSED_04515 3.46e-46 155.0 COG5491@1|root,arCOG00452@2157|Archaea,41T30@651137|Thaumarchaeota 651137|Thaumarchaeota D conserved protein implicated in secretion - - - - - - - - - - - - - k59_831668_2 436308.Nmar_0813 3.32e-20 82.8 arCOG08722@1|root,arCOG08722@2157|Archaea,41SSI@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_490638_1 1112214.AHIS01000012_gene25 2.42e-34 137.0 COG1629@1|root,COG4771@2|Bacteria,1MU9K@1224|Proteobacteria,2TTN6@28211|Alphaproteobacteria,2K1BR@204457|Sphingomonadales 204457|Sphingomonadales P TonB dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_998998_1 1279017.AQYJ01000025_gene732 9.05e-115 343.0 COG0057@1|root,COG0057@2|Bacteria,1MZE4@1224|Proteobacteria,1RMSI@1236|Gammaproteobacteria,465BD@72275|Alteromonadaceae 1236|Gammaproteobacteria G Belongs to the glyceraldehyde-3-phosphate dehydrogenase family gap - 1.2.1.12 ko:K00134 ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01061 RC00149 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - Gp_dh_C,Gp_dh_N k59_434936_1 1088721.NSU_0966 5.76e-51 176.0 COG2199@1|root,COG3706@2|Bacteria,1NC00@1224|Proteobacteria,2TU9T@28211|Alphaproteobacteria,2K2K4@204457|Sphingomonadales 204457|Sphingomonadales T Diguanylate cyclase - - 2.7.7.65 ko:K13590 ko04112,map04112 - - - ko00000,ko00001,ko01000 - - - GGDEF k59_490644_1 272556.CF65_01291 2.37e-148 449.0 COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,1RMS9@1236|Gammaproteobacteria,1Y6SS@135625|Pasteurellales 135625|Pasteurellales L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate uvrA - - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - ABC_tran k59_545960_1 95619.PM1_0220190 3.5e-31 111.0 COG0776@1|root,COG0776@2|Bacteria,1RH5Z@1224|Proteobacteria,1S61Z@1236|Gammaproteobacteria 1236|Gammaproteobacteria K This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control himA GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0032774,GO:0032991,GO:0032993,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043565,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0046483,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2001141 - ko:K04764 - - - - ko00000,ko03032,ko03036,ko03400 - - - Bac_DNA_binding k59_545960_2 1121374.KB891576_gene306 5.48e-30 119.0 COG0072@1|root,COG0072@2|Bacteria,1MWKS@1224|Proteobacteria,1RMIH@1236|Gammaproteobacteria 1236|Gammaproteobacteria J Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily pheT GO:0003674,GO:0003824,GO:0004812,GO:0004826,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0042802,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494 6.1.1.20 ko:K01890 ko00970,map00970 M00359,M00360 R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iG2583_1286.G2583_2160,iPC815.YPO2428 B3_4,B5,FDX-ACB,tRNA_bind k59_1281652_1 999141.GME_14795 7.48e-90 273.0 COG0190@1|root,COG0190@2|Bacteria,1MWU4@1224|Proteobacteria,1RNSW@1236|Gammaproteobacteria,1XHW1@135619|Oceanospirillales 135619|Oceanospirillales F Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate - - 1.5.1.5,3.5.4.9 ko:K01491 ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200 M00140,M00377 R01220,R01655 RC00202,RC00578 ko00000,ko00001,ko00002,ko01000 - - - THF_DHG_CYH,THF_DHG_CYH_C k59_1281652_2 1123400.KB904802_gene3183 4.85e-22 92.0 COG0788@1|root,COG0788@2|Bacteria,1MVCF@1224|Proteobacteria,1RN6Q@1236|Gammaproteobacteria,460DH@72273|Thiotrichales 72273|Thiotrichales F Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4) purU - 3.5.1.10 ko:K01433 ko00630,ko00670,map00630,map00670 - R00944 RC00026,RC00111 ko00000,ko00001,ko01000 - - - ACT,Formyl_trans_N k59_1451600_1 1122137.AQXF01000006_gene711 5.29e-76 228.0 COG5443@1|root,COG5443@2|Bacteria,1RD3V@1224|Proteobacteria,2U7PK@28211|Alphaproteobacteria 28211|Alphaproteobacteria N Flagellar biosynthesis repressor FlbT flbT - - ko:K06601 - - - - ko00000,ko02035 - - - FlbT k59_43678_1 247633.GP2143_02130 3.27e-92 277.0 COG0583@1|root,COG0583@2|Bacteria,1MZX1@1224|Proteobacteria,1RNFR@1236|Gammaproteobacteria,1J5AW@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria K transcriptional regulator ilvY GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - ko:K02521 - - - - ko00000,ko03000 - - - HTH_1,LysR_substrate k59_831700_1 1122137.AQXF01000001_gene2886 1.18e-96 296.0 COG2079@1|root,COG2079@2|Bacteria,1NECN@1224|Proteobacteria,2UQ0A@28211|Alphaproteobacteria 28211|Alphaproteobacteria S MmgE PrpD family protein - - - - - - - - - - - - MmgE_PrpD k59_831700_2 1122137.AQXF01000001_gene2887 1.3e-39 139.0 COG2266@1|root,COG2266@2|Bacteria,1RFQ8@1224|Proteobacteria,2U7WE@28211|Alphaproteobacteria 28211|Alphaproteobacteria H MobA-like NTP transferase domain - - - - - - - - - - - - NTP_transf_3 k59_1171989_1 479432.Sros_0773 1.18e-14 80.5 COG0457@1|root,COG2197@1|root,COG3899@1|root,COG0457@2|Bacteria,COG2197@2|Bacteria,COG3899@2|Bacteria,2I2U4@201174|Actinobacteria,4ER32@85012|Streptosporangiales 201174|Actinobacteria K AAA ATPase domain - - - - - - - - - - - - AAA_16,BTAD,GerE,Trans_reg_C k59_892047_1 1117647.M5M_00195 2.8e-66 206.0 COG0479@1|root,COG0479@2|Bacteria,1MVHS@1224|Proteobacteria,1RNWR@1236|Gammaproteobacteria,1J4VZ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C COG0479 Succinate dehydrogenase fumarate reductase, Fe-S protein subunit sdhB GO:0000104,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009055,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016627,GO:0016999,GO:0017144,GO:0019752,GO:0022900,GO:0022904,GO:0032991,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0045273,GO:0045274,GO:0045281,GO:0045282,GO:0045333,GO:0048037,GO:0051536,GO:0051537,GO:0051538,GO:0051539,GO:0051540,GO:0055114,GO:0070469,GO:0070470,GO:0071704,GO:0071944,GO:0072350,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1990204 1.3.5.1,1.3.5.4 ko:K00240 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00149,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 - - e_coli_core.b0724,iAF1260.b0724,iBWG_1329.BWG_0583,iEC042_1314.EC042_0742,iECDH10B_1368.ECDH10B_0791,iECDH1ME8569_1439.ECDH1ME8569_0683,iECUMN_1333.ECUMN_0802,iEcDH1_1363.EcDH1_2911,iJO1366.b0724,iJR904.b0724,iY75_1357.Y75_RS03765 Fer2_3,Fer4_17,Fer4_8 k59_892047_2 1117647.M5M_00200 9.18e-40 145.0 COG1053@1|root,COG1053@2|Bacteria,1MU5M@1224|Proteobacteria,1RMU2@1236|Gammaproteobacteria,1J4I0@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Belongs to the FAD-dependent oxidoreductase 2 family. FRD SDH subfamily sdhA GO:0000104,GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009055,GO:0009060,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016627,GO:0016999,GO:0017144,GO:0019752,GO:0022900,GO:0032991,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0045273,GO:0045274,GO:0045281,GO:0045282,GO:0045333,GO:0048037,GO:0050660,GO:0050662,GO:0055114,GO:0070469,GO:0070470,GO:0071704,GO:0071944,GO:0072350,GO:0097159,GO:0098796,GO:0098797,GO:0098803,GO:1901265,GO:1901363,GO:1902494,GO:1990204 1.3.5.1,1.3.5.4 ko:K00239 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134 M00009,M00011,M00149,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 - - iE2348C_1286.E2348C_0603,iJN746.PP_4191,iPC815.YPO1111 FAD_binding_2,Succ_DH_flav_C k59_327173_1 477228.YO5_11570 1.13e-21 92.4 COG1104@1|root,COG1104@2|Bacteria,1MU1C@1224|Proteobacteria,1RNCD@1236|Gammaproteobacteria,1Z0HB@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria E Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins iscS GO:0001522,GO:0003674,GO:0003824,GO:0004123,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006790,GO:0006807,GO:0008033,GO:0008144,GO:0008150,GO:0008152,GO:0008483,GO:0009000,GO:0009058,GO:0009451,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016226,GO:0016740,GO:0016769,GO:0016782,GO:0016783,GO:0016829,GO:0016846,GO:0018130,GO:0018131,GO:0019842,GO:0022607,GO:0030170,GO:0031071,GO:0031119,GO:0031163,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046484,GO:0048037,GO:0050662,GO:0051186,GO:0070279,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0097163,GO:0140104,GO:1901360,GO:1901363 2.8.1.7 ko:K04487 ko00730,ko01100,ko04122,map00730,map01100,map04122 - R07460,R11528,R11529 RC01789,RC02313 ko00000,ko00001,ko01000,ko02048,ko03016,ko03029 - - iPC815.YPO2896,iYL1228.KPN_02862 Aminotran_5 k59_327173_2 1121937.AUHJ01000002_gene3462 5.52e-51 169.0 COG0565@1|root,COG0565@2|Bacteria,1N47Y@1224|Proteobacteria,1RPD3@1236|Gammaproteobacteria,465US@72275|Alteromonadaceae 1236|Gammaproteobacteria J Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA trmJ - 2.1.1.200 ko:K02533,ko:K15396 - - - - ko00000,ko01000,ko03016 - - - SpoU_methylase k59_1400719_7 1274524.BSONL12_22865 2.31e-43 152.0 COG5113@1|root,COG3236@2|Bacteria,1V7IA@1239|Firmicutes 1239|Firmicutes O Protein conserved in bacteria ybiA - - ko:K09935 - - - - ko00000 - - - DUF1768 k59_1570807_1 926692.AZYG01000040_gene1540 7.54e-40 143.0 COG1212@1|root,COG1212@2|Bacteria,1TQU3@1239|Firmicutes,24H2B@186801|Clostridia,3WAKF@53433|Halanaerobiales 186801|Clostridia M Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria kdsB - 2.7.7.38 ko:K00979 ko00540,ko01100,map00540,map01100 M00063 R03351,R11396 RC00152,RC00910 ko00000,ko00001,ko00002,ko01000,ko01005 - - - CTP_transf_3 k59_1172003_1 1163617.SCD_n02443 5.03e-42 157.0 COG3850@1|root,COG5001@1|root,COG3850@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria 28216|Betaproteobacteria T Diguanylate cyclase - - - - - - - - - - - - CHASE,EAL,GGDEF,PAS,PAS_3 k59_1570811_1 1380394.JADL01000013_gene588 2e-102 307.0 COG1494@1|root,COG1494@2|Bacteria,1MUB1@1224|Proteobacteria,2TSPE@28211|Alphaproteobacteria,2JP9S@204441|Rhodospirillales 204441|Rhodospirillales G COG1494 Fructose-1,6-bisphosphatase sedoheptulose 1,7-bisphosphatase and related proteins glpX - 3.1.3.11,3.1.3.37 ko:K11532 ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200 M00003,M00165,M00167 R00762,R01845,R04780 RC00017 ko00000,ko00001,ko00002,ko01000 - - - FBPase_glpX k59_1570811_2 237368.SCABRO_01577 1.42e-159 461.0 COG0498@1|root,COG0498@2|Bacteria,2IXKE@203682|Planctomycetes 203682|Planctomycetes E Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine - - 4.2.3.1 ko:K01733 ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230 M00018 R01466,R05086 RC00017,RC00526 ko00000,ko00001,ko00002,ko01000 - - - PALP k59_1451621_1 1286632.P278_24200 2.18e-06 56.6 COG4219@1|root,COG4219@2|Bacteria,4NHAY@976|Bacteroidetes,1HXH6@117743|Flavobacteriia 976|Bacteroidetes KT Antirepressor regulating drug resistance - - - - - - - - - - - - Peptidase_M56,TonB_C k59_773012_1 1211815.CBYP010000036_gene2256 9.8e-56 191.0 COG0172@1|root,COG0172@2|Bacteria,2GIWP@201174|Actinobacteria,4EREN@85013|Frankiales 201174|Actinobacteria J Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) serS GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 6.1.1.11 ko:K01875 ko00970,map00970 M00359,M00360 R03662,R08218 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Seryl_tRNA_N,tRNA-synt_2b k59_773015_2 159087.Daro_3321 9.95e-36 123.0 COG4654@1|root,COG4654@2|Bacteria,1N6UN@1224|Proteobacteria,2VW1Y@28216|Betaproteobacteria,2KZ32@206389|Rhodocyclales 206389|Rhodocyclales C Cytochrome c - - - ko:K08738 ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416 M00595 R10151 RC03151,RC03152 ko00000,ko00001,ko00002 3.D.4.6 - - Cytochrom_C k59_269048_1 1206101.AZXC01000009_gene515 2.85e-51 182.0 COG0477@1|root,COG0477@2|Bacteria,2GITS@201174|Actinobacteria 201174|Actinobacteria EGP Major facilitator Superfamily - - - - - - - - - - - - MFS_1 k59_1623398_1 555079.Toce_1359 3.4e-50 172.0 COG0124@1|root,COG0124@2|Bacteria,1TP3D@1239|Firmicutes,24852@186801|Clostridia,42FQT@68295|Thermoanaerobacterales 186801|Clostridia J PFAM tRNA synthetase, class II (G, H, P and S) hisS - 6.1.1.21 ko:K01892 ko00970,map00970 M00359,M00360 R03655 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,tRNA-synt_His k59_1407688_1 1408422.JHYF01000014_gene147 9.7e-63 205.0 COG0108@1|root,COG0807@1|root,COG0108@2|Bacteria,COG0807@2|Bacteria,1TPH9@1239|Firmicutes,248B0@186801|Clostridia,36E7D@31979|Clostridiaceae 186801|Clostridia H Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate ribBA - 3.5.4.25,4.1.99.12 ko:K14652 ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110 M00125,M00840 R00425,R07281 RC00293,RC01792,RC01815,RC02504 ko00000,ko00001,ko00002,ko01000 - - iHN637.CLJU_RS10830 DHBP_synthase,GTP_cyclohydro2 k59_1458594_1 1297569.MESS2_1220034 8.88e-34 125.0 COG1442@1|root,COG1442@2|Bacteria,1QH4S@1224|Proteobacteria,2U9KQ@28211|Alphaproteobacteria,43JIY@69277|Phyllobacteriaceae 28211|Alphaproteobacteria M glycosyl transferase family 8 - - - - - - - - - - - - - k59_106444_1 1122137.AQXF01000003_gene1941 2.82e-101 303.0 COG2355@1|root,COG2355@2|Bacteria,1MWEW@1224|Proteobacteria,2TR5C@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Zn-dependent dipeptidase, microsomal dipeptidase - - 3.4.13.19 ko:K01273 - - - - ko00000,ko00537,ko01000,ko01002,ko04147 - - - Peptidase_M19 k59_949880_2 1538804.A0A0A1CM43_9CAUD 1.64e-14 74.7 4QB5I@10239|Viruses,4QPQ9@28883|Caudovirales,4QKRP@10699|Siphoviridae 10699|Siphoviridae S helicase activity - - - - - - - - - - - - - k59_333651_1 1185652.USDA257_c02220 5.26e-06 47.4 COG1522@1|root,COG1522@2|Bacteria,1RA2G@1224|Proteobacteria,2TTD9@28211|Alphaproteobacteria,4B95S@82115|Rhizobiaceae 28211|Alphaproteobacteria K Lrp/AsnC ligand binding domain - - - - - - - - - - - - AsnC_trans_reg,HTH_24 k59_333651_2 384765.SIAM614_18959 8.91e-68 217.0 COG0686@1|root,COG0686@2|Bacteria,1QTX1@1224|Proteobacteria,2TQQC@28211|Alphaproteobacteria 28211|Alphaproteobacteria C Belongs to the AlaDH PNT family ald - 1.4.1.1 ko:K00259 ko00250,ko00430,ko01100,map00250,map00430,map01100 - R00396 RC00008 ko00000,ko00001,ko01000 - - - AlaDh_PNT_C,AlaDh_PNT_N k59_899087_1 1313172.YM304_35460 1.27e-178 517.0 COG0365@1|root,COG0365@2|Bacteria,2GJCG@201174|Actinobacteria,4CMRX@84992|Acidimicrobiia 84992|Acidimicrobiia I AMP-binding enzyme C-terminal domain - - 6.2.1.1 ko:K01895 ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200 M00357 R00235,R00236,R00316,R00926,R01354 RC00004,RC00012,RC00043,RC00070,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000,ko01004 - - - ACAS_N,AMP-binding,AMP-binding_C k59_1288927_1 702113.PP1Y_AT21806 8.52e-78 254.0 COG5009@1|root,COG5009@2|Bacteria,1MU5A@1224|Proteobacteria,2USBB@28211|Alphaproteobacteria,2K0P9@204457|Sphingomonadales 204457|Sphingomonadales M Penicillin-binding Protein - - 2.4.1.129,3.4.16.4 ko:K05366 ko00550,ko01100,ko01501,map00550,map01100,map01501 - - - ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 - PCB_OB,Transgly,Transpeptidase k59_1066814_1 1242864.D187_000509 1.22e-31 122.0 COG0657@1|root,COG0657@2|Bacteria,1NEXK@1224|Proteobacteria,42T4X@68525|delta/epsilon subdivisions,2WPCA@28221|Deltaproteobacteria 28221|Deltaproteobacteria I alpha/beta hydrolase fold - - - ko:K01066 - - - - ko00000,ko01000 - - - Abhydrolase_3 k59_1685588_1 1347342.BN863_2510 1.34e-95 290.0 COG0577@1|root,COG0577@2|Bacteria,4NFUG@976|Bacteroidetes,1HZ09@117743|Flavobacteriia 976|Bacteroidetes V ABC-type antimicrobial peptide transport system, permease component - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_1520026_1 1122604.JONR01000009_gene2309 2.41e-85 261.0 COG1235@1|root,COG1235@2|Bacteria,1NW4Z@1224|Proteobacteria,1RPS3@1236|Gammaproteobacteria 1236|Gammaproteobacteria S COG1235 Metal-dependent hydrolases of the beta-lactamase superfamily I - - - - - - - - - - - - Lactamase_B_2 k59_106479_1 443143.GM18_2836 2.55e-44 151.0 COG0569@1|root,COG0569@2|Bacteria,1MW8R@1224|Proteobacteria,42NWZ@68525|delta/epsilon subdivisions,2WJU7@28221|Deltaproteobacteria,43VXP@69541|Desulfuromonadales 28221|Deltaproteobacteria C TrkA-N domain trkA - - ko:K03499 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - - TrkA_C,TrkA_N k59_160876_1 1499684.CCNP01000026_gene3792 8.42e-07 51.6 COG2197@1|root,COG2197@2|Bacteria,1VB97@1239|Firmicutes,24IHJ@186801|Clostridia,36RM8@31979|Clostridiaceae 186801|Clostridia T helix_turn_helix, Lux Regulon - - - - - - - - - - - - GerE,Response_reg k59_1288953_1 595460.RRSWK_00890 1.07e-52 186.0 COG0514@1|root,COG0514@2|Bacteria,2IX4R@203682|Planctomycetes 203682|Planctomycetes L DEAD DEAH box helicase - - 3.6.4.12 ko:K03654 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,HRDC,Helicase_C,RQC,RecQ_Zn_bind k59_1119643_1 1298598.JCM21714_4770 9.98e-51 176.0 COG3385@1|root,COG3385@2|Bacteria,1TSH6@1239|Firmicutes,4HEX8@91061|Bacilli 91061|Bacilli L PFAM transposase IS4 family protein - - - - - - - - - - - - DDE_5,DDE_Tnp_1 k59_218048_1 991905.SL003B_3272 1.23e-119 353.0 COG0078@1|root,COG0078@2|Bacteria,1MUFM@1224|Proteobacteria,2TR81@28211|Alphaproteobacteria,4BP6R@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria E Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline argF GO:0000050,GO:0003674,GO:0003824,GO:0004585,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0016743,GO:0019627,GO:0019752,GO:0034641,GO:0042450,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.1.3.3 ko:K00611 ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230 M00029,M00844 R01398 RC00096 ko00000,ko00001,ko00002,ko01000 - - - OTCace,OTCace_N k59_218048_2 1122137.AQXF01000004_gene1447 3.92e-211 590.0 COG4992@1|root,COG4992@2|Bacteria,1MV3C@1224|Proteobacteria,2TSGT@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Acetylornithine aminotransferase argD GO:0003674,GO:0005488,GO:0005515,GO:0008144,GO:0019842,GO:0030170,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0048037,GO:0050662,GO:0070279,GO:0097159,GO:1901363 2.6.1.11,2.6.1.17 ko:K00821 ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00028,M00845 R02283,R04475 RC00006,RC00062 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 k59_276109_1 330214.NIDE1815 2.52e-67 210.0 COG1310@1|root,COG1310@2|Bacteria,3J0U8@40117|Nitrospirae 40117|Nitrospirae S JAB/MPN domain - - 3.13.1.6 ko:K21140 ko04122,map04122 - R11524 RC00064,RC00090 ko00000,ko00001,ko01000 - - - Prok-JAB k59_1345139_1 35754.JNYJ01000046_gene3102 5.14e-102 319.0 COG1520@1|root,COG1520@2|Bacteria,2I9S4@201174|Actinobacteria,4D97G@85008|Micromonosporales 201174|Actinobacteria S beta-propeller repeat - - - - - - - - - - - - PQQ_2,PQQ_3 k59_1066829_1 1449353.JQMQ01000005_gene1103 6.1e-26 108.0 COG1109@1|root,COG1109@2|Bacteria,2GJQA@201174|Actinobacteria,2NGNK@228398|Streptacidiphilus 201174|Actinobacteria G Phosphoglucomutase/phosphomannomutase, C-terminal domain manB - 5.4.2.8 ko:K01840 ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130 M00114 R01818 RC00408 ko00000,ko00001,ko00002,ko01000 - - - PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV k59_390899_1 565045.NOR51B_2163 1.03e-67 226.0 COG2271@1|root,COG2271@2|Bacteria,1MWYR@1224|Proteobacteria,1RNBI@1236|Gammaproteobacteria 1236|Gammaproteobacteria G Major facilitator superfamily - - - - - - - - - - - - MFS_1,Sugar_tr k59_441808_1 4538.ORGLA03G0264200.1 1.76e-09 61.2 COG1670@1|root,2SC5M@2759|Eukaryota,37ZPT@33090|Viridiplantae,3GPMD@35493|Streptophyta,3KZBC@4447|Liliopsida,3IH5P@38820|Poales 35493|Streptophyta J Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_3 k59_441808_2 1336241.JAEB01000012_gene1775 1.08e-42 151.0 COG0631@1|root,COG0631@2|Bacteria,1V6K5@1239|Firmicutes,24JD4@186801|Clostridia,25W72@186806|Eubacteriaceae 186801|Clostridia T phosphatase stp - 3.1.3.16 ko:K20074 - - - - ko00000,ko01000,ko01009 - - - PP2C,PP2C_2 k59_441808_3 1231190.NA8A_20992 1.49e-23 99.0 COG0634@1|root,COG0634@2|Bacteria,1NRT8@1224|Proteobacteria,2TTN7@28211|Alphaproteobacteria,43IJQ@69277|Phyllobacteriaceae 28211|Alphaproteobacteria F Belongs to the purine pyrimidine phosphoribosyltransferase family hpt GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.4.2.8 ko:K00760 ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 - R00190,R01132,R01229,R02142,R08237,R08238,R08245 RC00063,RC00122 ko00000,ko00001,ko01000 - - - Pribosyltran k59_50473_1 1122137.AQXF01000003_gene2085 7.6e-79 257.0 COG4774@1|root,COG4774@2|Bacteria,1R6E9@1224|Proteobacteria,2UR6V@28211|Alphaproteobacteria 28211|Alphaproteobacteria P TonB dependent receptor - - - - - - - - - - - - Plug,TonB_dep_Rec k59_218057_1 518766.Rmar_1108 4.72e-77 257.0 COG0085@1|root,COG0085@2|Bacteria,4NF8D@976|Bacteroidetes,1FJ48@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoB GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234 2.7.7.6 ko:K03043 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7 k59_1288998_1 391165.GbCGDNIH1_0387 6.09e-15 75.1 COG0454@1|root,COG0456@2|Bacteria,1RIE6@1224|Proteobacteria,2UF5C@28211|Alphaproteobacteria,2JTU6@204441|Rhodospirillales 204441|Rhodospirillales K FR47-like protein rimI - 2.3.1.128 ko:K03789 - - - - ko00000,ko01000,ko03009 - - - Acetyltransf_1 k59_1178510_1 1415778.JQMM01000001_gene1238 3.35e-114 353.0 COG0542@1|root,COG0542@2|Bacteria,1MURH@1224|Proteobacteria,1RN55@1236|Gammaproteobacteria,1J534@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE clpB GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0006950,GO:0006986,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009266,GO:0009408,GO:0009628,GO:0010033,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030554,GO:0031249,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0035966,GO:0036094,GO:0042221,GO:0042623,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564 - ko:K03695 ko04213,map04213 - - - ko00000,ko00001,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N k59_1795014_1 1122201.AUAZ01000015_gene734 1.52e-76 236.0 COG0842@1|root,COG0842@2|Bacteria,1MUH1@1224|Proteobacteria,1RP0Z@1236|Gammaproteobacteria,46426@72275|Alteromonadaceae 1236|Gammaproteobacteria V Transport permease protein yadH GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane k59_160915_1 231434.JQJH01000006_gene43 9.13e-37 132.0 COG2346@1|root,COG2346@2|Bacteria,1RH21@1224|Proteobacteria,2U6GH@28211|Alphaproteobacteria,3NB96@45404|Beijerinckiaceae 28211|Alphaproteobacteria S Bacterial-like globin - - - ko:K06886 - - - - ko00000 - - - Bac_globin k59_1234358_1 489825.LYNGBM3L_28080 3.83e-25 110.0 COG0642@1|root,COG2199@1|root,COG2205@2|Bacteria,COG3706@2|Bacteria,1G09B@1117|Cyanobacteria,1H7M4@1150|Oscillatoriales 1117|Cyanobacteria T Signal transduction histidine kinase, subgroup 1, dimerisation phosphoacceptor domain - - - ko:K03320 - - - - ko00000,ko02000 1.A.11 - - HAMP,HATPase_c,HisKA,PAS_9,Response_reg,dCache_1 k59_1345166_1 359.CN09_33740 3.45e-32 135.0 COG0507@1|root,COG0507@2|Bacteria,1MUTR@1224|Proteobacteria,2TSQQ@28211|Alphaproteobacteria,4B77T@82115|Rhizobiaceae 28211|Alphaproteobacteria L conjugal transfer protein traA - - - - - - - - - - - - AAA_30,MobA_MobL,Relaxase,Viral_helicase1 k59_441836_1 1244869.H261_15060 4.91e-09 58.5 COG0472@1|root,COG0472@2|Bacteria,1MWYW@1224|Proteobacteria,2TTW6@28211|Alphaproteobacteria,2JRH3@204441|Rhodospirillales 204441|Rhodospirillales M COG0472 UDP-N-acetylmuramyl pentapeptide phosphotransferase UDP-N-acetylglucosamine-1-phosphate transferase wbpL - 2.7.8.33,2.7.8.35 ko:K02851,ko:K13007 - - R08856 RC00002 ko00000,ko01000,ko01003,ko01005 - - - Glycos_transf_4 k59_615850_1 1122599.AUGR01000015_gene2608 6.85e-41 153.0 COG1629@1|root,COG4771@2|Bacteria,1MUC1@1224|Proteobacteria,1RRFS@1236|Gammaproteobacteria,1XJ3N@135619|Oceanospirillales 135619|Oceanospirillales P receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_615853_1 448385.sce6695 7.8e-50 179.0 COG0654@1|root,COG0654@2|Bacteria,1MUN4@1224|Proteobacteria 1224|Proteobacteria CH COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases - - - - - - - - - - - - FAD_binding_3 k59_1178521_1 1096930.L284_15890 1.03e-17 82.4 COG0852@1|root,COG0852@2|Bacteria,1MX4B@1224|Proteobacteria,2TSMT@28211|Alphaproteobacteria,2K0IR@204457|Sphingomonadales 204457|Sphingomonadales C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoC - 1.6.5.3 ko:K00332 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_30kDa k59_1742677_1 1278073.MYSTI_03750 4.31e-47 166.0 COG0577@1|root,COG0577@2|Bacteria,1PBKH@1224|Proteobacteria,42MAR@68525|delta/epsilon subdivisions,2WJEU@28221|Deltaproteobacteria,2YWSR@29|Myxococcales 28221|Deltaproteobacteria V MacB-like periplasmic core domain - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_1119689_1 187272.Mlg_1887 5.17e-35 125.0 COG1959@1|root,COG1959@2|Bacteria,1RDA4@1224|Proteobacteria,1S3RW@1236|Gammaproteobacteria,1WY2N@135613|Chromatiales 135613|Chromatiales K Transcriptional regulator - - - ko:K13643 - - - - ko00000,ko03000 - - - Rrf2 k59_1577663_1 639030.JHVA01000001_gene743 1.81e-05 45.4 COG1664@1|root,COG1664@2|Bacteria,3Y5MK@57723|Acidobacteria,2JJXQ@204432|Acidobacteriia 204432|Acidobacteriia M Polymer-forming cytoskeletal - - - - - - - - - - - - Bactofilin k59_276152_1 557598.LHK_00267 2.79e-37 127.0 COG0096@1|root,COG0096@2|Bacteria,1RDG3@1224|Proteobacteria,2VRBD@28216|Betaproteobacteria,2KR19@206351|Neisseriales 206351|Neisseriales J One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit rpsH - - ko:K02994 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S8 k59_276152_2 306281.AJLK01000117_gene4144 4.69e-23 94.4 COG0097@1|root,COG0097@2|Bacteria,1G4ZT@1117|Cyanobacteria,1JHYC@1189|Stigonemataceae 1117|Cyanobacteria J Ribosomal protein L6 rpl6 GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02933 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L6 k59_497183_1 1173028.ANKO01000008_gene2104 2.78e-72 254.0 COG0642@1|root,COG3829@1|root,COG4251@1|root,COG0642@2|Bacteria,COG3829@2|Bacteria,COG4251@2|Bacteria,1GHC4@1117|Cyanobacteria 1117|Cyanobacteria T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - GAF,HATPase_c,HisKA,Hpt,PAS_2,PAS_3,PAS_9,PHY,Response_reg k59_390951_1 178901.AmDm5_2716 1.64e-39 144.0 COG0015@1|root,COG0015@2|Bacteria,1MV4B@1224|Proteobacteria,2TQUE@28211|Alphaproteobacteria,2JP8Z@204441|Rhodospirillales 204441|Rhodospirillales F Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily purB - 4.3.2.2 ko:K01756 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048,M00049 R01083,R04559 RC00379,RC00444,RC00445 ko00000,ko00001,ko00002,ko01000 - - - ADSL_C,Lyase_1 k59_390951_2 631362.Thi970DRAFT_03550 3.9e-26 111.0 COG4589@1|root,COG4589@2|Bacteria,1R34Q@1224|Proteobacteria,1T63B@1236|Gammaproteobacteria,1WWNK@135613|Chromatiales 135613|Chromatiales S Belongs to the CDS family - - 2.7.7.41 ko:K00981 ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070 M00093 R01799 RC00002 ko00000,ko00001,ko00002,ko01000 - - - CTP_transf_1 k59_218123_1 1117647.M5M_01580 1.95e-29 117.0 COG5429@1|root,COG5429@2|Bacteria,1MW6R@1224|Proteobacteria,1S834@1236|Gammaproteobacteria,1JAI4@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Protein of unknown function (DUF1223) - - - - - - - - - - - - DUF1223 k59_899192_1 398767.Glov_2292 9.47e-27 114.0 COG3303@1|root,COG3303@2|Bacteria,1R8WP@1224|Proteobacteria,42VEM@68525|delta/epsilon subdivisions,2WRGV@28221|Deltaproteobacteria 28221|Deltaproteobacteria C Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process - - - - - - - - - - - - - k59_552878_1 1144313.PMI10_02845 2.08e-40 150.0 COG0823@1|root,COG0823@2|Bacteria,4PHEF@976|Bacteroidetes,1I8WH@117743|Flavobacteriia,2NZ9X@237|Flavobacterium 976|Bacteroidetes U Involved in the tonB-independent uptake of proteins - - - - - - - - - - - - - k59_899193_2 1120956.JHZK01000025_gene1990 2.13e-06 49.7 COG3212@1|root,COG3212@2|Bacteria,1NHDB@1224|Proteobacteria,2UJN5@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Peptidase propeptide and YPEB domain - - - - - - - - - - - - PepSY,PepSY_2 k59_899193_3 1122137.AQXF01000003_gene2235 1.42e-57 184.0 COG0745@1|root,COG0745@2|Bacteria,1N0YI@1224|Proteobacteria,2TSV8@28211|Alphaproteobacteria 28211|Alphaproteobacteria T Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain feuP - - ko:K02483 - - - - ko00000,ko02022 - - - Response_reg,Trans_reg_C k59_949974_1 1415779.JOMH01000001_gene2493 1.29e-60 211.0 COG0525@1|root,COG0525@2|Bacteria,1MV7B@1224|Proteobacteria,1RNEB@1236|Gammaproteobacteria,1X2YZ@135614|Xanthomonadales 135614|Xanthomonadales J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner valS GO:0003674,GO:0003824,GO:0004812,GO:0004832,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006438,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.9 ko:K01873 ko00970,map00970 M00359,M00360 R03665 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1 k59_1345212_2 1380394.JADL01000010_gene4101 4.23e-43 143.0 COG0662@1|root,COG0662@2|Bacteria,1N71F@1224|Proteobacteria,2UFSH@28211|Alphaproteobacteria,2JUW5@204441|Rhodospirillales 204441|Rhodospirillales G AraC-like ligand binding domain - - - - - - - - - - - - Cupin_2 k59_1345212_3 1485544.JQKP01000007_gene2030 1.53e-58 185.0 COG1225@1|root,COG1225@2|Bacteria,1R9YF@1224|Proteobacteria,2VN9B@28216|Betaproteobacteria,44VDM@713636|Nitrosomonadales 28216|Betaproteobacteria O PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen - - - - - - - - - - - - AhpC-TSA k59_1178584_1 504487.JCM19302_1843 6.79e-62 194.0 COG1595@1|root,COG1595@2|Bacteria,4NHNI@976|Bacteroidetes,1HY4K@117743|Flavobacteriia 976|Bacteroidetes K Belongs to the sigma-70 factor family. ECF subfamily - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 k59_1178584_2 391587.KAOT1_21172 1.21e-21 86.3 2DP5F@1|root,330KU@2|Bacteria,4NV42@976|Bacteroidetes,1I5KT@117743|Flavobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_1520138_1 1229909.NSED_03615 8.14e-92 284.0 COG1351@1|root,arCOG01884@2157|Archaea,41SF6@651137|Thaumarchaeota 651137|Thaumarchaeota F Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant - - - - - - - - - - - - Thy1 k59_390977_1 1123371.ATXH01000014_gene1600 2.16e-06 50.1 COG0739@1|root,COG0739@2|Bacteria,2GI5Z@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria M Peptidase family M23 - - - - - - - - - - - - Peptidase_M23 k59_390977_2 1423743.JCM14108_396 2.31e-55 183.0 COG1194@1|root,COG1194@2|Bacteria,1TPUT@1239|Firmicutes,4H9UM@91061|Bacilli,3FCD0@33958|Lactobacillaceae 91061|Bacilli L A G-specific adenine glycosylase mutY - - ko:K03575 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - EndIII_4Fe-2S,HhH-GPD,NUDIX_4 k59_1234408_1 1304880.JAGB01000001_gene596 2.21e-53 180.0 COG2120@1|root,COG2120@2|Bacteria,1UYGC@1239|Firmicutes,25D0S@186801|Clostridia 186801|Clostridia S GlcNAc-PI de-N-acetylase - - - - - - - - - - - - PIG-L k59_1234408_2 316056.RPC_0827 5.3e-106 330.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2TQPG@28211|Alphaproteobacteria,3JTTQ@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria T Sigma-54 interaction domain - - - ko:K02481,ko:K07714 ko02020,map02020 M00500 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_615922_1 1229909.NSED_05460 6.34e-214 602.0 COG1884@1|root,arCOG04232@2157|Archaea,41SBW@651137|Thaumarchaeota 651137|Thaumarchaeota I Methylmalonyl-CoA mutase - - 5.4.99.2 ko:K01848 ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200 M00375,M00376,M00741 R00833 RC00395 ko00000,ko00001,ko00002,ko01000 - - - MM_CoA_mutase k59_1289078_1 1279017.AQYJ01000028_gene2033 3.73e-101 308.0 COG0301@1|root,COG0607@1|root,COG0301@2|Bacteria,COG0607@2|Bacteria,1MWD3@1224|Proteobacteria,1RNZT@1236|Gammaproteobacteria,4664X@72275|Alteromonadaceae 1236|Gammaproteobacteria H Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS thiI GO:0000049,GO:0002937,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0017144,GO:0018130,GO:0019438,GO:0034227,GO:0034470,GO:0034641,GO:0034660,GO:0042364,GO:0042723,GO:0042724,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:0090304,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.8.1.4 ko:K03151 ko00730,ko01100,ko04122,map00730,map01100,map04122 - R07461 - ko00000,ko00001,ko01000,ko03016 - - iECNA114_1301.ECNA114_0400,iECO26_1355.ECO26_0455,iECSF_1327.ECSF_0383,iSDY_1059.SDY_0307 THUMP,ThiI k59_1742729_1 1123240.ATVO01000009_gene747 4.38e-12 68.9 COG3653@1|root,COG3653@2|Bacteria,1MWWY@1224|Proteobacteria,2TSZZ@28211|Alphaproteobacteria,2K1RR@204457|Sphingomonadales 204457|Sphingomonadales Q Amidohydrolase family - - 3.5.1.81 ko:K06015 - - R02192 RC00064,RC00328 ko00000,ko01000 - - - Amidohydro_3 k59_1742729_2 153948.NAL212_1539 0.000564 41.6 COG0517@1|root,COG0517@2|Bacteria,1QTXQ@1224|Proteobacteria,2VWDB@28216|Betaproteobacteria,3734T@32003|Nitrosomonadales 28216|Betaproteobacteria S Domain in cystathionine beta-synthase and other proteins. - - - - - - - - - - - - CBS k59_729233_1 1121374.KB891576_gene146 2.35e-87 276.0 COG1292@1|root,COG1292@2|Bacteria,1MV0K@1224|Proteobacteria,1RP3E@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Belongs to the BCCT transporter (TC 2.A.15) family - - - ko:K03451 - - - - ko00000 2.A.15 - - BCCT k59_50530_1 1535422.ND16A_2509 3.74e-99 308.0 COG3808@1|root,COG3808@2|Bacteria,1MUQ3@1224|Proteobacteria,1RN4K@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force hppA - 3.6.1.1 ko:K15987 ko00190,map00190 - - - ko00000,ko00001,ko01000 3.A.10.1 - - H_PPase k59_668108_1 1120705.FG95_02810 3.78e-46 158.0 COG3185@1|root,COG3185@2|Bacteria,1MUVZ@1224|Proteobacteria,2TRCC@28211|Alphaproteobacteria,2K0BD@204457|Sphingomonadales 204457|Sphingomonadales E 4-hydroxyphenylpyruvate dioxygenase hppD - 1.13.11.27 ko:K00457 ko00130,ko00350,ko00360,ko01100,map00130,map00350,map00360,map01100 M00044 R01372,R02521 RC00505,RC00738 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Glyoxalase,Glyoxalase_5 k59_668108_2 1042377.AFPJ01000009_gene293 5.05e-14 69.3 COG1846@1|root,COG1846@2|Bacteria,1N1CJ@1224|Proteobacteria,1SCUJ@1236|Gammaproteobacteria,467UJ@72275|Alteromonadaceae 1236|Gammaproteobacteria K helix_turn_helix multiple antibiotic resistance protein - - - - - - - - - - - - MarR,MarR_2 k59_1066960_1 1085623.GNIT_1068 7.84e-49 180.0 COG2304@1|root,COG3419@1|root,COG2304@2|Bacteria,COG3419@2|Bacteria,1NUAV@1224|Proteobacteria,1RPV3@1236|Gammaproteobacteria,46578@72275|Alteromonadaceae 1236|Gammaproteobacteria NU Tfp pilus assembly protein tip-associated adhesin pilY1 - - ko:K02674 - - - - ko00000,ko02035,ko02044 - - - Neisseria_PilC,VWA_2 k59_50535_1 349124.Hhal_1852 1.05e-63 212.0 COG4949@1|root,COG4949@2|Bacteria,1MVI2@1224|Proteobacteria,1RR20@1236|Gammaproteobacteria,1WW7X@135613|Chromatiales 135613|Chromatiales S Protein of unknown function (DUF3422) - - - - - - - - - - - - DUF3422 k59_1407859_1 13690.CP98_03350 5.98e-16 73.2 COG1610@1|root,COG1610@2|Bacteria,1RGZS@1224|Proteobacteria,2U7DJ@28211|Alphaproteobacteria,2K3W5@204457|Sphingomonadales 204457|Sphingomonadales S Yqey-like protein - - - ko:K09117 - - - - ko00000 - - - YqeY k59_1407859_2 555793.WSK_1168 2.14e-42 148.0 COG0505@1|root,COG0505@2|Bacteria,1MUB9@1224|Proteobacteria,2TR3W@28211|Alphaproteobacteria,2K02X@204457|Sphingomonadales 204457|Sphingomonadales F Belongs to the CarA family carA - 6.3.5.5 ko:K01956 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - - CPSase_sm_chain,GATase k59_1407871_1 555500.I215_05405 7.09e-107 320.0 COG0612@1|root,COG0612@2|Bacteria,4NE0K@976|Bacteroidetes,1HZQH@117743|Flavobacteriia 976|Bacteroidetes S Insulinase (Peptidase family M16) - - - - - - - - - - - - Peptidase_M16,Peptidase_M16_C k59_790766_1 398579.Spea_2653 2.77e-69 233.0 COG1629@1|root,COG4206@1|root,COG4206@2|Bacteria,COG4771@2|Bacteria,1MU9K@1224|Proteobacteria,1RMTG@1236|Gammaproteobacteria,2QDJY@267890|Shewanellaceae 1236|Gammaproteobacteria M TonB dependent receptor - - - - - - - - - - - - Plug,TonB_dep_Rec k59_564849_1 1479238.JQMZ01000001_gene414 0.000643 40.8 COG3727@1|root,COG3727@2|Bacteria,1RH1C@1224|Proteobacteria,2UA6G@28211|Alphaproteobacteria,43XW3@69657|Hyphomonadaceae 28211|Alphaproteobacteria L May nick specific sequences that contain T G mispairs resulting from m5C-deamination vsr - - ko:K07458 - - - - ko00000,ko01000,ko03400 - - - Vsr k59_564849_2 314262.MED193_18659 2.79e-49 169.0 COG0270@1|root,COG0270@2|Bacteria,1MV9H@1224|Proteobacteria,2TTZG@28211|Alphaproteobacteria,2P3W1@2433|Roseobacter 28211|Alphaproteobacteria H C-5 cytosine-specific DNA methylase dcm - 2.1.1.37 ko:K00558 ko00270,ko01100,ko05206,map00270,map01100,map05206 M00035 R04858 RC00003,RC00332 ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036 - - - DNA_methylase,HTH_3,HTH_31 k59_790831_1 1229780.BN381_10199 4.22e-30 124.0 COG5617@1|root,COG5617@2|Bacteria,2H32H@201174|Actinobacteria 201174|Actinobacteria S Psort location CytoplasmicMembrane, score - - - - - - - - - - - - - k59_564865_1 1167006.UWK_00729 7.17e-66 237.0 COG0642@1|root,COG0745@1|root,COG0784@1|root,COG0745@2|Bacteria,COG0784@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,42M0Y@68525|delta/epsilon subdivisions,2WJCX@28221|Deltaproteobacteria,2MHXT@213118|Desulfobacterales 28221|Deltaproteobacteria T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - CHASE8,HAMP,HATPase_c,HisKA,Hpt,PAS_9,Response_reg,dCache_1 k59_564865_2 471223.GWCH70_0657 5.97e-12 71.6 COG2984@1|root,COG2984@2|Bacteria,1TPB0@1239|Firmicutes,4HESK@91061|Bacilli,1WEYZ@129337|Geobacillus 91061|Bacilli S ABC transporter substrate binding protein - - - ko:K01989 - M00247 - - ko00000,ko00002,ko02000 - - - ABC_sub_bind k59_790866_2 32057.KB217478_gene6478 3.85e-34 136.0 COG2831@1|root,COG2831@2|Bacteria,1G03B@1117|Cyanobacteria 1117|Cyanobacteria U Hemolysin activation secretion protein - - - - - - - - - - - - POTRA_2,ShlB k59_790880_1 935557.ATYB01000009_gene1090 1.56e-24 99.0 COG2993@1|root,COG2993@2|Bacteria,1MXEY@1224|Proteobacteria,2TRGW@28211|Alphaproteobacteria,4BASB@82115|Rhizobiaceae 28211|Alphaproteobacteria C cytochrome C oxidase mono-heme subunit FixO ccoO - - ko:K00405 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00156 - - ko00000,ko00001,ko00002 3.D.4.3 - - FixO k59_790880_2 1279038.KB907342_gene2645 4.87e-09 53.9 COG4736@1|root,COG4736@2|Bacteria,1NKCP@1224|Proteobacteria,2VB11@28211|Alphaproteobacteria,2JUH5@204441|Rhodospirillales 204441|Rhodospirillales O Cbb3-type cytochrome oxidase component FixQ - - - ko:K00407 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00156 - - ko00000,ko00001,ko00002 3.D.4.3 - - FixQ k59_790898_1 1123503.KB908056_gene2195 8.44e-08 53.1 COG1028@1|root,COG1028@2|Bacteria,1MU3W@1224|Proteobacteria,2TT5X@28211|Alphaproteobacteria,2KGMQ@204458|Caulobacterales 204458|Caulobacterales IQ KR domain - - - - - - - - - - - - adh_short_C2 k59_564941_1 404589.Anae109_0645 3.62e-09 57.8 COG1352@1|root,COG1352@2|Bacteria,1MU6W@1224|Proteobacteria,42MR2@68525|delta/epsilon subdivisions,2WKKH@28221|Deltaproteobacteria,2YX13@29|Myxococcales 28221|Deltaproteobacteria H Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP cheR2 - 2.1.1.80 ko:K00575 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko01000,ko02035 - - - CheR,CheR_N,Response_reg k59_564941_2 1307759.JOMJ01000003_gene774 3.36e-29 118.0 COG2201@1|root,COG2201@2|Bacteria,1MWCN@1224|Proteobacteria,42M27@68525|delta/epsilon subdivisions,2WJ2S@28221|Deltaproteobacteria,2M8VE@213115|Desulfovibrionales 28221|Deltaproteobacteria NT catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR cheB34H - 3.1.1.61,3.5.1.44 ko:K03412 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko02022,ko02035 - - - CheB_methylest,Response_reg k59_790948_1 553385.JEMF01000124_gene3345 8.07e-78 246.0 COG1611@1|root,COG1611@2|Bacteria,1MVQJ@1224|Proteobacteria,1RQHX@1236|Gammaproteobacteria,1XHP4@135619|Oceanospirillales 135619|Oceanospirillales S Rossmann fold nucleotide-binding protein - - 3.2.2.10 ko:K06966 ko00230,ko00240,map00230,map00240 - R00182,R00510 RC00063,RC00318 ko00000,ko00001,ko01000 - - - DUF3412,DUF4478,Lysine_decarbox k59_1806521_1 1229909.NSED_06890 4.74e-40 136.0 COG4088@1|root,arCOG01041@2157|Archaea 2157|Archaea F PFAM Chromatin associated protein KTI12 pstK - 2.7.1.164,2.7.1.25 ko:K00860,ko:K10837 ko00230,ko00450,ko00920,ko00970,ko01100,ko01120,map00230,map00450,map00920,map00970,map01100,map01120 M00176 R00509,R04928,R08223 RC00002,RC00017,RC00078 ko00000,ko00001,ko00002,ko01000 - - - AAA_33,KTI12 k59_790965_1 436308.Nmar_0289 1.47e-65 204.0 COG0461@1|root,arCOG00029@2157|Archaea,41SJU@651137|Thaumarchaeota 651137|Thaumarchaeota F Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) pyrE - 2.4.2.10 ko:K00762 ko00240,ko01100,map00240,map01100 M00051 R01870 RC00611 ko00000,ko00001,ko00002,ko01000 - - - Pribosyltran k59_1806571_1 344747.PM8797T_20388 1.13e-139 407.0 COG1593@1|root,COG1593@2|Bacteria,2J2ZT@203682|Planctomycetes 203682|Planctomycetes G Tripartite ATP-independent periplasmic transporter, DctM component - - - - - - - - - - - - DctM k59_1806602_2 1116472.MGMO_218c00040 4.36e-204 565.0 COG2367@1|root,COG2367@2|Bacteria,1NMW4@1224|Proteobacteria,1RWGW@1236|Gammaproteobacteria 1236|Gammaproteobacteria V Beta-lactamase bla - 3.5.2.6 ko:K17836,ko:K18698,ko:K18795,ko:K19217 ko00311,ko01130,ko01501,map00311,map01130,map01501 M00627,M00628 R06363 RC01499 br01600,ko00000,ko00001,ko00002,ko01000,ko01504 - - - Beta-lactamase2 k59_1806602_3 171101.spr0975 8.4e-169 489.0 COG2984@1|root,COG2984@2|Bacteria,1TPB0@1239|Firmicutes,4HESK@91061|Bacilli,1WUNF@1313|Streptococcus pneumoniae 91061|Bacilli S ABC transporter substrate binding protein ABC-SBP - - ko:K01989 - M00247 - - ko00000,ko00002,ko02000 - - - ABC_sub_bind k59_1806602_4 45351.EDO49451 1.01e-32 124.0 2EV3P@1|root,2SX5F@2759|Eukaryota,3ARW5@33154|Opisthokonta 33154|Opisthokonta S Green fluorescent protein - - - - - - - - - - - - GFP k59_1806749_1 1298867.AUES01000051_gene4511 3.33e-62 217.0 COG0771@1|root,COG2931@1|root,COG4625@1|root,COG0771@2|Bacteria,COG2931@2|Bacteria,COG4625@2|Bacteria,1MU7T@1224|Proteobacteria,2TRVY@28211|Alphaproteobacteria,3K2H3@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria Q Haemolysin-type calcium-binding repeat (2 copies) - - - - - - - - - - - - FG-GAP,HemolysinCabind k59_1582525_1 519989.ECTPHS_07062 2.19e-93 284.0 COG1894@1|root,COG1894@2|Bacteria,1MV8F@1224|Proteobacteria,1RMUD@1236|Gammaproteobacteria,1WWH3@135613|Chromatiales 135613|Chromatiales C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain nuoF - 1.6.5.3 ko:K00335 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_51K,NADH_4Fe-4S,SLBB k59_452508_2 1437425.CSEC_2141 0.000634 41.2 COG0058@1|root,COG0058@2|Bacteria,2JFEH@204428|Chlamydiae 204428|Chlamydiae G Carbohydrate phosphorylase glgP - 2.4.1.1 ko:K00688 ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931 - R02111 - ko00000,ko00001,ko01000 - GT35 - Phosphorylase k59_57300_1 1380600.AUYN01000007_gene3273 1.21e-63 199.0 COG1286@1|root,COG1286@2|Bacteria,4NRG9@976|Bacteroidetes,1I2B6@117743|Flavobacteriia 976|Bacteroidetes S Colicin V production protein cvpA - - ko:K03558 - - - - ko00000 - - - Colicin_V k59_1582528_1 338969.Rfer_1223 2.75e-19 89.7 COG1463@1|root,COG1463@2|Bacteria,1R565@1224|Proteobacteria,2VK63@28216|Betaproteobacteria,4AA5X@80864|Comamonadaceae 28216|Betaproteobacteria Q Mammalian cell entry related domain protein - - - ko:K02067 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - MlaD k59_1526103_1 1211817.CCAT010000083_gene1714 7.64e-06 53.1 COG5002@1|root,COG5002@2|Bacteria,1UJFB@1239|Firmicutes,25G6U@186801|Clostridia,36V53@31979|Clostridiaceae 186801|Clostridia T Signal transduction histidine kinase - - - - - - - - - - - - HAMP,HATPase_c,HisKA k59_57305_1 1150864.MILUP08_41570 2.72e-41 152.0 COG0612@1|root,COG0612@2|Bacteria,2GJZ3@201174|Actinobacteria,4D8I3@85008|Micromonosporales 201174|Actinobacteria S Belongs to the peptidase M16 family pepR GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - - - - - - - - - - Peptidase_M16,Peptidase_M16_C k59_904554_1 857087.Metme_2235 2.86e-12 69.3 COG1639@1|root,COG2204@1|root,COG1639@2|Bacteria,COG2204@2|Bacteria,1R6YN@1224|Proteobacteria,1S0UQ@1236|Gammaproteobacteria 1236|Gammaproteobacteria T response regulator - - - - - - - - - - - - HDOD,Response_reg k59_700_2 208444.JNYY01000006_gene7323 2.19e-10 57.4 2DCTW@1|root,2ZFB7@2|Bacteria,2HNZM@201174|Actinobacteria,4E7H5@85010|Pseudonocardiales 201174|Actinobacteria - - - - - - - - - - - - - - - k59_57336_1 1121912.AUHD01000010_gene3573 3.43e-55 193.0 COG0489@1|root,COG3206@1|root,COG0489@2|Bacteria,COG3206@2|Bacteria,4NEXU@976|Bacteroidetes,1HXKJ@117743|Flavobacteriia 976|Bacteroidetes DM protein involved in exopolysaccharide biosynthesis wzc - - - - - - - - - - - AAA_31,GNVR,Wzz k59_622090_1 1187851.A33M_3361 4.43e-29 117.0 COG0330@1|root,COG0330@2|Bacteria,1MV7R@1224|Proteobacteria,2TRP4@28211|Alphaproteobacteria,3FD2U@34008|Rhodovulum 28211|Alphaproteobacteria O HflC and HflK could regulate a protease hflC - - ko:K04087 - M00742 - - ko00000,ko00002,ko01000 - - - Band_7 k59_170231_3 436308.Nmar_1313 1.06e-74 224.0 COG0640@1|root,arCOG00731@2157|Archaea 2157|Archaea K regulatory protein, arsR - - - - - - - - - - - - HTH_5 k59_904555_1 768671.ThimaDRAFT_0499 3.05e-103 317.0 COG0286@1|root,COG0286@2|Bacteria,1MW3A@1224|Proteobacteria,1RRVF@1236|Gammaproteobacteria,1WXG6@135613|Chromatiales 135613|Chromatiales V PFAM N-6 DNA methylase - - 2.1.1.72 ko:K03427 - - - - ko00000,ko01000,ko02048 - - - HsdM_N,N6_Mtase k59_1356590_1 767434.Fraau_2209 0.000118 44.3 COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,1RPCB@1236|Gammaproteobacteria,1X489@135614|Xanthomonadales 135614|Xanthomonadales O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner lon - 3.4.21.53 ko:K01338 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - AAA,LON_substr_bdg,Lon_C k59_1356590_2 187272.Mlg_2287 5.32e-33 125.0 COG1219@1|root,COG1219@2|Bacteria,1MVQK@1224|Proteobacteria,1RN9N@1236|Gammaproteobacteria,1WX82@135613|Chromatiales 135613|Chromatiales O ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP clpX - - ko:K03544 ko04112,map04112 - - - ko00000,ko00001,ko03110 - - - AAA_2,ClpB_D2-small,zf-C4_ClpX k59_791814_1 1121937.AUHJ01000003_gene3317 1.18e-75 229.0 COG0720@1|root,COG0720@2|Bacteria,1N10D@1224|Proteobacteria,1SBJZ@1236|Gammaproteobacteria 1236|Gammaproteobacteria H synthase - - 4.1.2.50,4.2.3.12 ko:K01737 ko00790,ko01100,map00790,map01100 M00842,M00843 R04286,R09959 RC01117,RC02846,RC02847 ko00000,ko00001,ko00002,ko01000,ko03016 - - - PTPS k59_961090_1 1101191.KI912577_gene1450 6.42e-23 102.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,2TQR7@28211|Alphaproteobacteria,1JRPX@119045|Methylobacteriaceae 28211|Alphaproteobacteria NT Four helix bundle sensory module for signal transduction - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - 4HB_MCP_1,HAMP,MCPsignal k59_732_1 2340.JV46_05690 2.99e-168 479.0 COG2826@1|root,COG2826@2|Bacteria,1PP49@1224|Proteobacteria,1RN7B@1236|Gammaproteobacteria,1JBRQ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L L COG2826 Transposase and inactivated derivatives, IS30 family insI GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003824,GO:0004803,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006310,GO:0006313,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0030983,GO:0032135,GO:0032196,GO:0032991,GO:0032993,GO:0034641,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363 - ko:K07482 - - - - ko00000 - - - HTH_38,rve k59_565833_1 1121035.AUCH01000017_gene2280 4.79e-42 144.0 COG2078@1|root,COG2078@2|Bacteria,1RJP4@1224|Proteobacteria,2VRE4@28216|Betaproteobacteria,2KWM9@206389|Rhodocyclales 206389|Rhodocyclales S AMMECR1 - - - - - - - - - - - - AMMECR1 k59_1752099_1 215803.DB30_6131 6.29e-67 208.0 COG1428@1|root,COG1428@2|Bacteria,1RC50@1224|Proteobacteria,42ZS6@68525|delta/epsilon subdivisions,2WUZM@28221|Deltaproteobacteria,2YYRA@29|Myxococcales 28221|Deltaproteobacteria F Deoxynucleoside kinase - - - - - - - - - - - - dNK k59_1752099_2 1280692.AUJL01000032_gene466 1.94e-14 71.2 COG0634@1|root,COG0634@2|Bacteria,1V1C9@1239|Firmicutes,24FR4@186801|Clostridia,36HYM@31979|Clostridiaceae 186801|Clostridia F Belongs to the purine pyrimidine phosphoribosyltransferase family hpt - 2.4.2.8 ko:K00760 ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 - R00190,R01132,R01229,R02142,R08237,R08238,R08245 RC00063,RC00122 ko00000,ko00001,ko01000 - - - Pribosyltran k59_283407_1 102129.Lepto7375DRAFT_1521 5.14e-110 331.0 COG2008@1|root,COG2008@2|Bacteria,1G4PN@1117|Cyanobacteria 1117|Cyanobacteria E Threonine aldolase - - 4.1.2.48 ko:K01620 ko00260,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map01100,map01110,map01120,map01130,map01230 - R00751,R06171 RC00312,RC00372 ko00000,ko00001,ko01000 - - - Beta_elim_lyase k59_283407_2 1382306.JNIM01000001_gene1067 1.38e-06 56.6 COG0613@1|root,COG0613@2|Bacteria 2|Bacteria Q PHP domain protein - - - - - - - - - - - - Glyco_trans_1_4,Glyco_transf_4,PHP,PHP_C k59_678639_1 305700.B447_06827 6.59e-38 146.0 COG4585@1|root,COG4585@2|Bacteria,1RGET@1224|Proteobacteria,2VPRS@28216|Betaproteobacteria,2KZ4H@206389|Rhodocyclales 206389|Rhodocyclales T Histidine kinase - - - - - - - - - - - - HATPase_c,HisKA_3 k59_678639_2 1218075.BAYA01000047_gene6713 1.35e-16 80.1 COG2823@1|root,COG2823@2|Bacteria,1RA8T@1224|Proteobacteria,2VRH6@28216|Betaproteobacteria,1K1XG@119060|Burkholderiaceae 28216|Betaproteobacteria S SMART Transport-associated and nodulation region - - - - - - - - - - - - BON k59_1243649_1 1121933.AUHH01000029_gene2016 2.7e-32 128.0 COG0631@1|root,COG0631@2|Bacteria,2GJ3M@201174|Actinobacteria,4DNAN@85009|Propionibacteriales 201174|Actinobacteria T Serine/threonine phosphatases, family 2C, catalytic domain pstP GO:0000287,GO:0001932,GO:0001933,GO:0003674,GO:0003824,GO:0004647,GO:0004721,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0006464,GO:0006469,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009892,GO:0009987,GO:0010563,GO:0010605,GO:0016020,GO:0016021,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019220,GO:0019222,GO:0019538,GO:0030145,GO:0030312,GO:0031224,GO:0031226,GO:0031323,GO:0031324,GO:0031399,GO:0031400,GO:0032268,GO:0032269,GO:0033673,GO:0036211,GO:0042325,GO:0042326,GO:0042578,GO:0043085,GO:0043086,GO:0043167,GO:0043169,GO:0043170,GO:0043392,GO:0043412,GO:0043549,GO:0044092,GO:0044093,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0045859,GO:0045936,GO:0046872,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050794,GO:0051098,GO:0051100,GO:0051101,GO:0051171,GO:0051172,GO:0051174,GO:0051246,GO:0051248,GO:0051338,GO:0051348,GO:0060255,GO:0065007,GO:0065009,GO:0071704,GO:0071944,GO:0080090,GO:0140096,GO:1901564 3.1.3.16 ko:K20074 - - - - ko00000,ko01000,ko01009 - - - PP2C,PP2C_2 k59_452571_1 1120965.AUBV01000007_gene2587 7.49e-30 112.0 COG4731@1|root,COG4731@2|Bacteria,4NQCK@976|Bacteroidetes,47R93@768503|Cytophagia 976|Bacteroidetes S Uncharacterized protein conserved in bacteria (DUF2147) - - - - - - - - - - - - DUF2147 k59_738_1 583355.Caka_2625 5.78e-24 103.0 COG1409@1|root,COG1409@2|Bacteria 2|Bacteria S acid phosphatase activity - - - - - - - - - - - - Metallophos,PA14 k59_452577_1 1117647.M5M_01575 1.85e-100 311.0 COG2905@1|root,COG2905@2|Bacteria,1MW8U@1224|Proteobacteria,1RPSJ@1236|Gammaproteobacteria,1J4Z1@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T containing cAMP-binding and CBS domains - - - ko:K07182 - - - - ko00000 - - - CBS,DUF294,DUF294_C,cNMP_binding k59_1074049_1 316407.85676396 6.75e-139 406.0 COG0272@1|root,COG0272@2|Bacteria,1MUZ1@1224|Proteobacteria,1RN3F@1236|Gammaproteobacteria,3XMXN@561|Escherichia 1236|Gammaproteobacteria L catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction ligB GO:0003674,GO:0003824,GO:0003909,GO:0003911,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016874,GO:0016886,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360,GO:1901576 6.5.1.2 ko:K01972 ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430 - R00382 RC00005 ko00000,ko00001,ko01000,ko03032,ko03400 - - - DNA_ligase_OB,DNA_ligase_aden,HHH_5 k59_791850_1 158500.BV97_05244 1.16e-22 95.9 COG0477@1|root,COG2814@2|Bacteria,1MVQQ@1224|Proteobacteria,2TRBF@28211|Alphaproteobacteria,2K8W9@204457|Sphingomonadales 204457|Sphingomonadales EGP Uncharacterised MFS-type transporter YbfB - - - - - - - - - - - - MFS_1,MFS_4 k59_791850_2 1112204.GPOL_c35180 6.13e-15 75.5 COG0169@1|root,COG0169@2|Bacteria,2GPXV@201174|Actinobacteria,4GD1G@85026|Gordoniaceae 201174|Actinobacteria E Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) aroE GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019632,GO:0019752,GO:0030266,GO:0032787,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046417,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0070403,GO:0071704,GO:0097159,GO:1901265,GO:1901363,GO:1901576,GO:1901615 1.1.1.25 ko:K00014 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02413 RC00206 ko00000,ko00001,ko00002,ko01000 - - - SKI,Shikimate_DH,Shikimate_dh_N,ThiF k59_1356640_1 566466.NOR53_2871 2.03e-74 234.0 COG2133@1|root,COG2133@2|Bacteria,1MV2E@1224|Proteobacteria,1RNGN@1236|Gammaproteobacteria,1J8IM@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria G Glucose / Sorbosone dehydrogenase yliI - - ko:K21430 - - - - ko00000,ko01000 - - - GSDH k59_1469763_1 1121127.JAFA01000006_gene5482 8.28e-90 280.0 COG1053@1|root,COG1053@2|Bacteria,1MU5M@1224|Proteobacteria,2VI6D@28216|Betaproteobacteria,1K5TM@119060|Burkholderiaceae 28216|Betaproteobacteria C Fumarate reductase flavoprotein C-term - - 1.3.5.1,1.3.5.4 ko:K00239,ko:K00244 ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,ko05134,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020,map05134 M00009,M00011,M00149,M00150,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,Succ_DH_flav_C k59_1469765_2 1096930.L284_13810 9.22e-28 101.0 2AG9X@1|root,316FF@2|Bacteria,1NC5A@1224|Proteobacteria,2UIGH@28211|Alphaproteobacteria,2K6YZ@204457|Sphingomonadales 204457|Sphingomonadales - - - - - - - - - - - - - - - k59_1469765_3 1096930.L284_13805 2.3e-53 173.0 2AKT6@1|root,2ZJDT@2|Bacteria,1P2JX@1224|Proteobacteria,2UU8J@28211|Alphaproteobacteria,2K5GD@204457|Sphingomonadales 204457|Sphingomonadales - - - - - - - - - - - - - - - k59_1752117_1 702113.PP1Y_AT26999 6.9e-32 117.0 COG5319@1|root,COG5319@2|Bacteria,1MZN2@1224|Proteobacteria,2UBTA@28211|Alphaproteobacteria,2K54Q@204457|Sphingomonadales 204457|Sphingomonadales S protein conserved in bacteria - - - - - - - - - - - - DUF1178 k59_1356645_1 1453501.JELR01000001_gene1901 4.49e-73 235.0 COG2114@1|root,COG2114@2|Bacteria,1MV1V@1224|Proteobacteria,1SZ0N@1236|Gammaproteobacteria,46CIY@72275|Alteromonadaceae 1236|Gammaproteobacteria T Adenylyl- / guanylyl cyclase, catalytic domain - - 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 - - - Guanylate_cyc,HAMP k59_170307_2 864702.OsccyDRAFT_1184 5.95e-28 114.0 COG0841@1|root,COG0841@2|Bacteria,1G0C2@1117|Cyanobacteria,1H7C3@1150|Oscillatoriales 1117|Cyanobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K18138 ko01501,ko01503,map01501,map01503 M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000 2.A.6.2 - - ACR_tran k59_622140_2 1229909.NSED_09820 2.87e-27 101.0 arCOG08816@1|root,arCOG08816@2157|Archaea,41TAW@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_622140_3 436308.Nmar_0040 5.21e-59 187.0 COG0603@1|root,arCOG00039@2157|Archaea,41SGR@651137|Thaumarchaeota 651137|Thaumarchaeota H Queuosine biosynthesis protein QueC - - 6.3.4.20 ko:K06920 ko00790,ko01100,map00790,map01100 - R09978 RC00959 ko00000,ko00001,ko01000,ko03016 - - - QueC k59_509206_1 1173026.Glo7428_3456 5.05e-24 105.0 COG0702@1|root,COG0702@2|Bacteria,1FZZN@1117|Cyanobacteria 1117|Cyanobacteria GM complex i intermediate-associated protein 30 - - - - - - - - - - - - CIA30,NAD_binding_10 k59_961140_1 929704.Myrod_0161 1.62e-19 91.3 COG3489@1|root,COG3489@2|Bacteria,4NHKU@976|Bacteroidetes,1IKX5@117743|Flavobacteriia,47IQV@76831|Myroides 976|Bacteroidetes S Imelysin - - - - - - - - - - - - Peptidase_M75 k59_565872_1 452662.SJA_C1-18900 1.55e-66 223.0 COG4206@1|root,COG4206@2|Bacteria,1MUZG@1224|Proteobacteria,2TUNP@28211|Alphaproteobacteria,2K1AW@204457|Sphingomonadales 204457|Sphingomonadales H receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_622146_1 1123023.JIAI01000009_gene1184 3.33e-17 83.2 COG1884@1|root,COG1884@2|Bacteria,2GNBQ@201174|Actinobacteria,4DYG1@85010|Pseudonocardiales 201174|Actinobacteria I Methylmalonyl-CoA mutase mutA GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016999,GO:0017144,GO:0019541,GO:0019678,GO:0019752,GO:0030312,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046459,GO:0071704,GO:0071944 5.4.99.2 ko:K01847 ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200 M00373,M00376,M00741 R00833 RC00395 ko00000,ko00001,ko00002,ko01000 - - - MM_CoA_mutase k59_622146_2 426355.Mrad2831_1736 1.4e-52 182.0 COG2185@1|root,COG2185@2|Bacteria,1QU3N@1224|Proteobacteria,2TVY1@28211|Alphaproteobacteria,1JS9Z@119045|Methylobacteriaceae 28211|Alphaproteobacteria I Methylmalonyl-CoA mutase - - 5.4.99.2 ko:K01847 ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200 M00373,M00376,M00741 R00833 RC00395 ko00000,ko00001,ko00002,ko01000 - - - B12-binding,MM_CoA_mutase k59_904646_1 246194.CHY_0277 0.000286 45.1 COG0110@1|root,COG0110@2|Bacteria,1V1SM@1239|Firmicutes,25B93@186801|Clostridia,42GXQ@68295|Thermoanaerobacterales 186801|Clostridia S Hexapeptide repeat of succinyl-transferase - - - - - - - - - - - - Hexapep,Hexapep_2 k59_1074072_1 85643.Tmz1t_1774 3.3e-96 298.0 COG1154@1|root,COG1154@2|Bacteria,1MUSJ@1224|Proteobacteria,2VHXG@28216|Betaproteobacteria,2KUSZ@206389|Rhodocyclales 206389|Rhodocyclales H Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) dxs - 2.2.1.7 ko:K01662 ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130 M00096 R05636 RC00032 ko00000,ko00001,ko00002,ko01000 - - - DXP_synthase_N,Transket_pyr,Transketolase_C k59_1305864_1 1096930.L284_05130 3.5e-92 282.0 COG0635@1|root,COG0635@2|Bacteria,1MV1I@1224|Proteobacteria,2TRKT@28211|Alphaproteobacteria,2K1GX@204457|Sphingomonadales 204457|Sphingomonadales H Belongs to the anaerobic coproporphyrinogen-III oxidase family hemN - - - - - - - - - - - Radical_SAM k59_797466_1 436114.SYO3AOP1_0211 3.42e-112 336.0 COG0499@1|root,COG0499@2|Bacteria,2G3TI@200783|Aquificae 200783|Aquificae H May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine ahcY GO:0000096,GO:0003674,GO:0003824,GO:0004013,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006534,GO:0006555,GO:0006575,GO:0006725,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009066,GO:0009069,GO:0009116,GO:0009119,GO:0009987,GO:0016787,GO:0016801,GO:0016802,GO:0017144,GO:0019752,GO:0033353,GO:0034641,GO:0042278,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046128,GO:0046439,GO:0046483,GO:0046498,GO:0046500,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564,GO:1901605,GO:1901657 3.3.1.1 ko:K01251 ko00270,ko01100,map00270,map01100 M00035 R00192,R04936 RC00056,RC00069,RC01161,RC01243 ko00000,ko00001,ko00002,ko01000,ko01009,ko04147 - - - AdoHcyase,AdoHcyase_NAD k59_1305865_2 1538295.JY96_13835 4.19e-36 134.0 COG0492@1|root,COG1145@1|root,COG0492@2|Bacteria,COG1145@2|Bacteria,1PD5J@1224|Proteobacteria,2W9PK@28216|Betaproteobacteria,1KMZ3@119065|unclassified Burkholderiales 28216|Betaproteobacteria C L-lysine 6-monooxygenase (NADPH-requiring) - - - - - - - - - - - - Pyr_redox_3 k59_910122_1 1229909.NSED_09045 8.95e-09 55.5 arCOG08770@1|root,arCOG08770@2157|Archaea,41T2S@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_910122_2 436308.Nmar_1700 1.17e-96 290.0 COG1527@1|root,arCOG02459@2157|Archaea,41T18@651137|Thaumarchaeota 651137|Thaumarchaeota C ATP synthase (C/AC39) subunit - - - ko:K02119 ko00190,ko01100,map00190,map01100 M00159 - - ko00000,ko00001,ko00002 3.A.2.2,3.A.2.3 - - vATP-synt_AC39 k59_289182_1 1461580.CCAS010000025_gene2537 1.11e-14 77.8 COG1388@1|root,COG3858@1|root,COG4932@1|root,COG1388@2|Bacteria,COG3858@2|Bacteria,COG4932@2|Bacteria,1TQK2@1239|Firmicutes,4HCVX@91061|Bacilli,1ZDSG@1386|Bacillus 91061|Bacilli M Glycosyl hydrolases family 18 - - - - - - - - - - - - Glyco_hydro_18,LysM k59_175723_1 1267534.KB906759_gene1678 1.05e-31 127.0 COG0855@1|root,COG0855@2|Bacteria,3Y2YI@57723|Acidobacteria,2JIKB@204432|Acidobacteriia 204432|Acidobacteriia P Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) ppk - 2.7.4.1 ko:K00937 ko00190,ko03018,map00190,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - PP_kinase,PP_kinase_C,PP_kinase_N k59_797487_1 155864.EDL933_4333 2.28e-85 263.0 COG1760@1|root,COG1760@2|Bacteria,1MUZN@1224|Proteobacteria,1RMJZ@1236|Gammaproteobacteria,3XNG8@561|Escherichia 1236|Gammaproteobacteria E L-serine ammonia-lyase activity tdcG GO:0003674,GO:0003824,GO:0003941,GO:0006082,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009987,GO:0016054,GO:0016829,GO:0016840,GO:0016841,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0071704,GO:1901564,GO:1901565,GO:1901575 4.3.1.17 ko:K01752 ko00260,ko00270,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00270,map01100,map01110,map01130,map01200,map01230 - R00220,R00590 RC00331,RC02600 ko00000,ko00001,ko01000 - - iECSP_1301.ECSP_4084,iECUMN_1333.ECUMN_2106 SDH_alpha,SDH_beta k59_1758483_1 408672.NBCG_03353 8.98e-24 100.0 COG5395@1|root,COG5395@2|Bacteria,2IITX@201174|Actinobacteria,4DWW8@85009|Propionibacteriales 201174|Actinobacteria S Predicted membrane protein (DUF2306) - - - - - - - - - - - - DUF2306 k59_1758483_2 1384054.N790_04225 5.67e-33 120.0 COG0625@1|root,COG0625@2|Bacteria,1MXHH@1224|Proteobacteria,1RNWZ@1236|Gammaproteobacteria,1X4GA@135614|Xanthomonadales 135614|Xanthomonadales O Belongs to the GST superfamily gst6 - 2.5.1.18 ko:K00799 ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418 - R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905 RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944 ko00000,ko00001,ko01000,ko02000 1.A.12.2.2,1.A.12.3.2 - - GST_C,GST_C_3,GST_N,GST_N_3 k59_1136955_1 563192.HMPREF0179_05325 3.95e-31 128.0 COG2931@1|root,COG3210@1|root,COG2931@2|Bacteria,COG3210@2|Bacteria,1MU7T@1224|Proteobacteria,42PPF@68525|delta/epsilon subdivisions,2WM3K@28221|Deltaproteobacteria,2MG5Z@213115|Desulfovibrionales 28221|Deltaproteobacteria Q COG2931, RTX toxins and related Ca2 -binding proteins - - - - - - - - - - - - - k59_1024799_1 1123256.KB907948_gene2697 9.76e-11 61.6 COG1506@1|root,COG1506@2|Bacteria,1P6E1@1224|Proteobacteria,1RPRK@1236|Gammaproteobacteria,1X2XM@135614|Xanthomonadales 135614|Xanthomonadales E peptidase - - 3.4.14.5 ko:K01278 ko04974,map04974 - - - ko00000,ko00001,ko01000,ko01002,ko04090,ko04147 - - - DPPIV_N,PD40,Peptidase_S9 k59_402664_1 1038867.AXAY01000034_gene31 5.66e-93 285.0 COG0446@1|root,COG0446@2|Bacteria,1QSG6@1224|Proteobacteria,2TUP1@28211|Alphaproteobacteria,3JSU5@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S Pyridine nucleotide-disulphide oxidoreductase sqr - 1.8.5.4 ko:K17218 ko00920,map00920 - R10152 RC03155 ko00000,ko00001,ko01000 - - - Pyr_redox_2 k59_571916_1 1170562.Cal6303_5688 4.01e-52 192.0 COG0515@1|root,COG1672@1|root,COG2203@1|root,COG3899@1|root,COG0515@2|Bacteria,COG1672@2|Bacteria,COG2203@2|Bacteria,COG3899@2|Bacteria,1GIES@1117|Cyanobacteria,1HJBM@1161|Nostocales 1117|Cyanobacteria KLT PFAM Protein kinase domain - - - - - - - - - - - - AAA_16,AAA_35,GAF,Pkinase k59_232967_1 309807.SRU_1363 4.5e-72 238.0 COG0449@1|root,COG0449@2|Bacteria,4NE8Q@976|Bacteroidetes,1FIV2@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source glmS GO:0003674,GO:0003824,GO:0004360,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006002,GO:0006040,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009987,GO:0016740,GO:0016769,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0036211,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576 2.6.1.16 ko:K00820 ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931 - R00768 RC00010,RC00163,RC02752 ko00000,ko00001,ko01000,ko01002 - - - GATase_6,SIS k59_290231_1 1254432.SCE1572_39610 1.5e-46 166.0 COG5520@1|root,COG5520@2|Bacteria,1N9T9@1224|Proteobacteria,43836@68525|delta/epsilon subdivisions,2X3D4@28221|Deltaproteobacteria,2YVHE@29|Myxococcales 28221|Deltaproteobacteria G Belongs to the glycosyl hydrolase 30 family srfJ - 3.2.1.45 ko:K01201 ko00511,ko00600,ko01100,ko04142,map00511,map00600,map01100,map04142 - R01498 RC00059,RC00451 ko00000,ko00001,ko01000 - GH30 - Glyco_hydro_30,Glyco_hydro_30C,RicinB_lectin_2 k59_515203_1 1000565.METUNv1_01303 2.82e-45 167.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,2KV5K@206389|Rhodocyclales 206389|Rhodocyclales T Putative diguanylate phosphodiesterase - - - - - - - - - - - - EAL,GGDEF,PAS_9 k59_1532799_1 1122137.AQXF01000006_gene915 8.86e-86 259.0 COG2199@1|root,COG3706@2|Bacteria,1QZ3H@1224|Proteobacteria,2TY4B@28211|Alphaproteobacteria 28211|Alphaproteobacteria T diguanylate cyclase - - - - - - - - - - - - GGDEF k59_64347_1 1415778.JQMM01000001_gene1803 8.67e-131 383.0 COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,1RMFF@1236|Gammaproteobacteria,1J50Z@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes lpdG GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 1.8.1.4 ko:K00382 ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00036,M00307,M00532 R00209,R01221,R01698,R03815,R07618,R08549 RC00004,RC00022,RC00583,RC02742,RC02833,RC02834 br01601,ko00000,ko00001,ko00002,ko01000,ko04147 - - iE2348C_1286.E2348C_4372,iJN746.PP_4187 Pyr_redox_2,Pyr_redox_dim k59_1645938_2 3055.EDO97376 2.22e-51 172.0 COG0177@1|root,KOG1921@2759|Eukaryota,37PW5@33090|Viridiplantae,34JQG@3041|Chlorophyta 3041|Chlorophyta L Bifunctional DNA N-glycosylase with associated apurinic apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N- glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines NTH1 - 4.2.99.18 ko:K10773 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - HhH-GPD k59_1532803_1 1219077.VAZ01S_053_00390 1.3e-40 141.0 2DDDN@1|root,32U19@2|Bacteria,1N1UD@1224|Proteobacteria,1SAT8@1236|Gammaproteobacteria,1XUWT@135623|Vibrionales 135623|Vibrionales - - - - - - - - - - - - - - - k59_1080539_1 1286171.EAL2_c06130 2.28e-112 340.0 COG3328@1|root,COG3328@2|Bacteria,1TP4C@1239|Firmicutes,248UI@186801|Clostridia,25VGM@186806|Eubacteriaceae 186801|Clostridia L Transposase, Mutator family - - - ko:K07493 - - - - ko00000 - - - Transposase_mut k59_1701879_1 42565.FP66_10020 1.1e-93 285.0 COG0156@1|root,COG0156@2|Bacteria,1MVVH@1224|Proteobacteria,1RNS6@1236|Gammaproteobacteria,1XHUW@135619|Oceanospirillales 135619|Oceanospirillales H Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA kbl - 2.3.1.29 ko:K00639 ko00260,map00260 - R00371 RC00004,RC00394 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_1_2 k59_1363248_1 366602.Caul_3942 3.52e-115 351.0 COG0457@1|root,COG0457@2|Bacteria,1MVMG@1224|Proteobacteria,2TSGE@28211|Alphaproteobacteria,2KFVS@204458|Caulobacterales 204458|Caulobacterales S Sulfotransferase - - - - - - - - - - - - Sulfotransfer_3,TPR_14,TPR_16,TPR_19,TPR_8 k59_1532809_1 1131266.ARWQ01000015_gene752 4.63e-20 85.9 COG0461@1|root,arCOG00029@2157|Archaea,41SJU@651137|Thaumarchaeota 651137|Thaumarchaeota F Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) pyrE - 2.4.2.10 ko:K00762 ko00240,ko01100,map00240,map01100 M00051 R01870 RC00611 ko00000,ko00001,ko00002,ko01000 - - - Pribosyltran k59_1532809_2 436308.Nmar_0290 1.72e-78 243.0 COG3875@1|root,arCOG02046@2157|Archaea,41SK4@651137|Thaumarchaeota 651137|Thaumarchaeota S Domain of unknown function (DUF2088) - - - - - - - - - - - - - k59_855158_1 511.JT27_16990 4.75e-19 85.9 COG0784@1|root,COG0784@2|Bacteria,1RGD3@1224|Proteobacteria,2VUMK@28216|Betaproteobacteria 28216|Betaproteobacteria T Response regulator receiver - - - - - - - - - - - - HTH_17,Response_reg k59_741858_1 160492.XF_0973 2.18e-23 103.0 COG0642@1|root,COG0784@1|root,COG0784@2|Bacteria,COG2205@2|Bacteria,1MUY7@1224|Proteobacteria,1RP2U@1236|Gammaproteobacteria,1X43U@135614|Xanthomonadales 135614|Xanthomonadales T Histidine kinase - - 2.7.13.3 ko:K10819 - - - - ko00000,ko01000 - - - HATPase_c,HisKA,PAS_7,Response_reg,dCache_1 k59_402692_2 870187.Thini_0611 1.57e-20 92.8 COG2211@1|root,COG2211@2|Bacteria,1MVUM@1224|Proteobacteria,1RP5J@1236|Gammaproteobacteria,45ZNH@72273|Thiotrichales 72273|Thiotrichales G MFS/sugar transport protein - - - - - - - - - - - - MFS_2 k59_1701890_1 330214.NIDE2567 1.33e-43 152.0 COG0436@1|root,COG0436@2|Bacteria,3J0EV@40117|Nitrospirae 40117|Nitrospirae E Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - 2.6.1.1 ko:K00812 ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230 - R00355,R00694,R00734,R00896,R02433,R02619,R05052 RC00006 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_1_2 k59_1701890_2 330214.NIDE2566 2.8e-54 173.0 COG0669@1|root,COG0669@2|Bacteria,3J0MF@40117|Nitrospirae 40117|Nitrospirae F Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate coaD - 2.7.7.3 ko:K00954 ko00770,ko01100,map00770,map01100 M00120 R03035 RC00002 ko00000,ko00001,ko00002,ko01000 - - - CTP_transf_like k59_1476468_1 349521.HCH_04416 3.84e-125 373.0 COG2010@1|root,COG2010@2|Bacteria,1N3PN@1224|Proteobacteria,1RNS0@1236|Gammaproteobacteria,1XICD@135619|Oceanospirillales 135619|Oceanospirillales C Cytochrome D1 heme domain - - 1.7.2.1,1.7.99.1 ko:K15864 ko00910,ko01120,map00910,map01120 M00529 R00143,R00783,R00785 RC00086,RC02797 ko00000,ko00001,ko00002,ko01000 - - - Cytochrom_D1,Cytochrome_CBB3 k59_459224_1 999541.bgla_1g06860 3.52e-18 84.3 COG0324@1|root,COG0324@2|Bacteria,1MUB2@1224|Proteobacteria,2VHEP@28216|Betaproteobacteria,1K1TT@119060|Burkholderiaceae 28216|Betaproteobacteria J Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) miaA - 2.5.1.75 ko:K00791 ko00908,ko01100,ko01110,map00908,map01100,map01110 - R01122 RC02820 ko00000,ko00001,ko01000,ko01006,ko03016 - - - IPPT k59_459224_2 1121918.ARWE01000001_gene1198 5.82e-25 105.0 COG0323@1|root,COG0323@2|Bacteria,1MV61@1224|Proteobacteria,42MFX@68525|delta/epsilon subdivisions,2WJ91@28221|Deltaproteobacteria,43T6C@69541|Desulfuromonadales 28221|Deltaproteobacteria L This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex mutL GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - ko:K03572 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - DNA_mis_repair,HATPase_c_3,MutL_C k59_1645959_1 502025.Hoch_5252 2.21e-163 513.0 COG0745@1|root,COG1340@1|root,COG1352@1|root,COG2201@1|root,COG2203@1|root,COG5002@1|root,COG0745@2|Bacteria,COG1340@2|Bacteria,COG1352@2|Bacteria,COG2201@2|Bacteria,COG2203@2|Bacteria,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,42NK9@68525|delta/epsilon subdivisions,2WMCQ@28221|Deltaproteobacteria 28221|Deltaproteobacteria T Response regulator receiver - - 2.1.1.80,3.1.1.61 ko:K13924 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko02022,ko02035 - - - CheB_methylest,CheR,CheR_N,GAF_2,HATPase_c,HisKA,PAS_10,PAS_3,PAS_4,PAS_9,Response_reg k59_1306971_1 85643.Tmz1t_1180 9.88e-61 196.0 COG1058@1|root,COG1058@2|Bacteria,1MVG6@1224|Proteobacteria,2VHTD@28216|Betaproteobacteria,2KUEQ@206389|Rhodocyclales 206389|Rhodocyclales S Molybdopterin binding - - - - - - - - - - - - MoCF_biosynth k59_571956_1 316407.85676110 1.28e-210 600.0 COG1882@1|root,COG1882@2|Bacteria,1MWBF@1224|Proteobacteria,1RMEK@1236|Gammaproteobacteria,3XNTU@561|Escherichia 1236|Gammaproteobacteria C formate C-acetyltransferase activity pflD - 2.3.1.54 ko:K00656 ko00620,ko00640,ko00650,ko01100,ko01120,map00620,map00640,map00650,map01100,map01120 - R00212,R06987 RC00004,RC01181,RC02742,RC02833 ko00000,ko00001,ko01000 - - iECH74115_1262.ECH74115_5411,iECSP_1301.ECSP_5020,iECs_1301.ECs4880,iZ_1308.Z5507 Gly_radical,PFL-like k59_7596_1 457415.HMPREF1006_01449 1.45e-28 119.0 COG5421@1|root,COG5421@2|Bacteria,3TAD9@508458|Synergistetes 508458|Synergistetes L Transposase DDE domain - - - - - - - - - - - - DDE_Tnp_1 k59_515262_1 222534.KB893671_gene3315 6.24e-33 125.0 COG0134@1|root,COG0134@2|Bacteria,2GIVV@201174|Actinobacteria,4ERMN@85013|Frankiales 201174|Actinobacteria E Belongs to the TrpC family trpC GO:0000162,GO:0000287,GO:0003674,GO:0003824,GO:0004425,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016020,GO:0016053,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019752,GO:0030312,GO:0034641,GO:0040007,GO:0042401,GO:0042430,GO:0042435,GO:0043167,GO:0043169,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046219,GO:0046391,GO:0046394,GO:0046483,GO:0046872,GO:0071704,GO:0071944,GO:1901135,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.1.1.48 ko:K01609 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R03508 RC00944 ko00000,ko00001,ko00002,ko01000 - - - IGPS k59_515262_2 1353529.M899_0429 4.6e-13 70.9 COG0745@1|root,COG0745@2|Bacteria,1MY2Z@1224|Proteobacteria,42MP1@68525|delta/epsilon subdivisions,2MTYK@213481|Bdellovibrionales,2WJPD@28221|Deltaproteobacteria 213481|Bdellovibrionales K PFAM response regulator receiver - - - ko:K07657 ko02020,map02020 M00434 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Trans_reg_C k59_1363290_1 870187.Thini_4131 8.56e-26 103.0 COG1183@1|root,COG1183@2|Bacteria,1MWD9@1224|Proteobacteria,1RPBB@1236|Gammaproteobacteria,4603D@72273|Thiotrichales 72273|Thiotrichales I Belongs to the CDP-alcohol phosphatidyltransferase class-I family - - 2.7.8.8 ko:K17103 ko00260,ko00564,ko01100,ko01110,map00260,map00564,map01100,map01110 M00093 R01800 RC00002,RC00017,RC02795 ko00000,ko00001,ko00002,ko01000 - - - CDP-OH_P_transf k59_1363290_2 1245471.PCA10_48610 5.07e-48 162.0 COG0059@1|root,COG0059@2|Bacteria,1MV7M@1224|Proteobacteria,1RNA8@1236|Gammaproteobacteria,1YERV@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria EH Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate ilvC GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004455,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006549,GO:0006573,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009097,GO:0009099,GO:0009987,GO:0016043,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0022607,GO:0036094,GO:0042802,GO:0043167,GO:0043169,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046872,GO:0048037,GO:0050661,GO:0050662,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:0097159,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.86 ko:K00053 ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R03051,R04439,R04440,R05068,R05069,R05071 RC00726,RC00836,RC00837,RC01726 ko00000,ko00001,ko00002,ko01000 - - iEC042_1314.EC042_4152,iECABU_c1320.ECABU_c42560,iECED1_1282.ECED1_4460,iECO103_1326.ECO103_4390,iECO111_1330.ECO111_4600,iECO26_1355.ECO26_4812,iECP_1309.ECP_3967,iECSE_1348.ECSE_4057,iECUMN_1333.ECUMN_4300,iEcE24377_1341.EcE24377A_4285,iEcSMS35_1347.EcSMS35_4140,iJN746.PP_4678,iLF82_1304.LF82_1103 IlvC,IlvN k59_1645968_1 1122137.AQXF01000001_gene2940 3.17e-296 819.0 COG1960@1|root,COG1960@2|Bacteria,1MU20@1224|Proteobacteria,2TQJS@28211|Alphaproteobacteria 28211|Alphaproteobacteria I acyl-CoA dehydrogenase MA20_19860 - 1.3.8.7 ko:K00249 ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320 M00013,M00036,M00087 R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754 RC00052,RC00068,RC00076,RC00095,RC00148,RC00246 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_C,Acyl-CoA_dh_M,Acyl-CoA_dh_N,AcylCoA_DH_N k59_402708_2 648757.Rvan_0446 1.26e-40 137.0 COG0633@1|root,COG0633@2|Bacteria,1RHDC@1224|Proteobacteria,2U97J@28211|Alphaproteobacteria,3N745@45401|Hyphomicrobiaceae 28211|Alphaproteobacteria C ferredoxin fdx - - ko:K04755 - - - - ko00000 - - - Fer2 k59_459249_2 1432056.X781_21330 2.55e-51 170.0 COG3005@1|root,COG3005@2|Bacteria,1MWV2@1224|Proteobacteria,1RQ9A@1236|Gammaproteobacteria,1Y70Y@135625|Pasteurellales 135625|Pasteurellales C Cytochrome c-type protein napC GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0022900,GO:0031224,GO:0044237,GO:0044425,GO:0044464,GO:0045333,GO:0055114,GO:0071944 - ko:K02569 - - - - ko00000 - - - Cytochrom_NNT k59_1363299_1 1117647.M5M_13023 2.2e-54 192.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1J5F8@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria V AcrB/AcrD/AcrF family - - - - - - - - - - - - ACR_tran k59_290290_1 83219.PM02_05800 2.56e-157 448.0 COG3396@1|root,COG3396@2|Bacteria,1MVQ7@1224|Proteobacteria,2TTC4@28211|Alphaproteobacteria,3ZVKH@60136|Sulfitobacter 28211|Alphaproteobacteria S Phenylacetic acid catabolic protein paaA - 1.14.13.149 ko:K02609 ko00360,ko01120,map00360,map01120 - R09838 RC02690 ko00000,ko00001,ko01000 - - - PaaA_PaaC k59_7618_1 717605.Theco_3637 1.76e-33 126.0 COG1305@1|root,COG1305@2|Bacteria,1V4HE@1239|Firmicutes,4HF4E@91061|Bacilli,26UF4@186822|Paenibacillaceae 91061|Bacilli E transglutaminase - - - - - - - - - - - - Bact_transglu_N,Transglut_core k59_176678_1 395963.Bind_2265 3e-70 217.0 COG3837@1|root,COG3837@2|Bacteria,1N15Q@1224|Proteobacteria,2UDER@28211|Alphaproteobacteria 28211|Alphaproteobacteria S PFAM Cupin 2 conserved barrel domain protein manC - - - - - - - - - - - Cupin_2 k59_346790_1 1229909.NSED_07745 3.38e-23 95.1 COG1718@1|root,arCOG01180@2157|Archaea,41T2X@651137|Thaumarchaeota 651137|Thaumarchaeota T Serine threonine protein kinase involved in cell cycle control - - 2.7.11.1 ko:K07178 ko03008,map03008 - - - ko00000,ko00001,ko01000,ko01001,ko03009 - - - RIO1 k59_346790_2 436308.Nmar_1411 2.75e-41 139.0 COG2412@1|root,arCOG04051@2157|Archaea,41SS6@651137|Thaumarchaeota 651137|Thaumarchaeota S Protein of unknown function (DUF424) - - - ko:K09148 - - - - ko00000 - - - DUF424 k59_1419426_1 511145.b3517 2.19e-147 424.0 COG0076@1|root,COG0076@2|Bacteria,1MX25@1224|Proteobacteria,1RNSQ@1236|Gammaproteobacteria,3XMMA@561|Escherichia 1236|Gammaproteobacteria E Converts glutamate to gamma-aminobutyrate (GABA), consuming one intracellular proton in the reaction. The gad system helps to maintain a near-neutral intracellular pH when cells are exposed to extremely acidic conditions. The ability to survive transit through the acidic conditions of the stomach is essential for successful colonization of the mammalian host by commensal and pathogenic bacteria gadA GO:0003674,GO:0003824,GO:0004351,GO:0006873,GO:0006885,GO:0008150,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0019725,GO:0030003,GO:0030004,GO:0030641,GO:0042592,GO:0045852,GO:0048878,GO:0050801,GO:0051453,GO:0051454,GO:0055067,GO:0055080,GO:0055082,GO:0065007,GO:0065008,GO:0098771 4.1.1.15 ko:K01580 ko00250,ko00410,ko00430,ko00650,ko01100,ko01110,ko01120,ko02024,ko04727,ko04940,map00250,map00410,map00430,map00650,map01100,map01110,map01120,map02024,map04727,map04940 M00027 R00261,R00489,R01682,R02466 RC00299 ko00000,ko00001,ko00002,ko01000 - - iAF1260.b3517,iE2348C_1286.E2348C_3759,iECDH1ME8569_1439.ECDH1ME8569_3396,iECUMN_1333.ECUMN_1747,iEcDH1_1363.EcDH1_0196,iEcolC_1368.EcolC_0200,iJO1366.b3517,iJR904.b3517 Pyridoxal_deC k59_1363304_1 243275.TDE_1049 6.15e-76 248.0 COG0480@1|root,COG0480@2|Bacteria,2J5M8@203691|Spirochaetes 203691|Spirochaetes J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome fusA - - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2 k59_459260_2 1229909.NSED_09800 1.81e-12 70.1 arCOG10414@1|root,arCOG10414@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_855195_1 999611.KI421504_gene1313 7.02e-111 350.0 COG1014@1|root,COG4231@1|root,COG1014@2|Bacteria,COG4231@2|Bacteria,1MUKS@1224|Proteobacteria,2TSHH@28211|Alphaproteobacteria,27ZIY@191028|Leisingera 28211|Alphaproteobacteria C Pyruvate ferredoxin/flavodoxin oxidoreductase MA20_06130 - 1.2.7.8 ko:K04090 - - - - br01601,ko00000,ko01000 - - - POR,TPP_enzyme_C k59_233062_1 1385515.N791_02635 2.58e-57 201.0 COG2937@1|root,COG2937@2|Bacteria,1MWZ6@1224|Proteobacteria,1RM7K@1236|Gammaproteobacteria,1X4M7@135614|Xanthomonadales 135614|Xanthomonadales I Belongs to the GPAT DAPAT family plsB - 2.3.1.15 ko:K00631 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R00851,R09380 RC00004,RC00039,RC00041 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Acyltransferase k59_1419432_1 395493.BegalDRAFT_2934 1.53e-77 256.0 COG0045@1|root,COG0454@1|root,COG1042@1|root,COG0045@2|Bacteria,COG0456@2|Bacteria,COG1042@2|Bacteria,1MW98@1224|Proteobacteria,1RPXX@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Acyl-CoA synthetase (NDP forming) - - - ko:K09181 - - - - ko00000 - - - ATP-grasp_5,Acetyltransf_1,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig k59_741907_1 1122137.AQXF01000003_gene2173 4.15e-112 351.0 COG0643@1|root,COG0643@2|Bacteria,1MUAG@1224|Proteobacteria,2TSN2@28211|Alphaproteobacteria 28211|Alphaproteobacteria T Histidine kinase cheA - 2.7.13.3 ko:K03407 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 - - - CheW,H-kinase_dim,HATPase_c,Hpt,Response_reg k59_1080627_1 1458357.BG58_36465 1.42e-49 174.0 COG2985@1|root,COG2985@2|Bacteria,1MUVM@1224|Proteobacteria,2VKQA@28216|Betaproteobacteria,1K03M@119060|Burkholderiaceae 28216|Betaproteobacteria S Aspartate alanine antiporter aspT - - - - - - - - - - - Asp-Al_Ex,TrkA_C k59_233072_1 1195246.AGRI_08710 2.44e-22 100.0 COG0477@1|root,COG2814@2|Bacteria,1QUD1@1224|Proteobacteria,1RQ0V@1236|Gammaproteobacteria,463Z1@72275|Alteromonadaceae 1236|Gammaproteobacteria EGP Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 k59_1419437_1 1415778.JQMM01000001_gene569 8.38e-15 74.7 COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,1RNJI@1236|Gammaproteobacteria,1J4RW@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L DNA helicase uvrD GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006289,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009628,GO:0009987,GO:0015616,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017116,GO:0022607,GO:0031297,GO:0032392,GO:0032508,GO:0033554,GO:0034641,GO:0034645,GO:0042623,GO:0042802,GO:0043142,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0045005,GO:0046483,GO:0050896,GO:0051259,GO:0051260,GO:0051276,GO:0051716,GO:0065003,GO:0070035,GO:0070581,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360,GO:1901576 3.6.4.12 ko:K03657 ko03420,ko03430,map03420,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - UvrD-helicase,UvrD_C k59_1419437_2 519989.ECTPHS_01184 3.35e-71 229.0 COG0569@1|root,COG0569@2|Bacteria,1MW8R@1224|Proteobacteria,1RNVQ@1236|Gammaproteobacteria,1WVX7@135613|Chromatiales 135613|Chromatiales P PFAM TrkA-N domain trkA - - ko:K03499 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - - TrkA_C,TrkA_N k59_1701923_1 436229.JOEH01000048_gene6873 1.86e-26 110.0 28HRJ@1|root,2Z7YZ@2|Bacteria,2GKNT@201174|Actinobacteria,2NH5K@228398|Streptacidiphilus 201174|Actinobacteria - - - - - - - - - - - - - - - k59_855207_1 1122604.JONR01000001_gene1738 6.48e-69 223.0 COG0114@1|root,COG0114@2|Bacteria,1MUQI@1224|Proteobacteria,1RNUS@1236|Gammaproteobacteria,1X3ED@135614|Xanthomonadales 135614|Xanthomonadales C Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate fumC - 4.2.1.2 ko:K01679 ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04934,ko05200,ko05211,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200,map04934,map05200,map05211 M00009,M00011,M00173,M00376 R01082 RC00443 ko00000,ko00001,ko00002,ko01000 - - - FumaraseC_C,Lyase_1 k59_1758594_2 395494.Galf_2514 3.82e-33 126.0 COG0119@1|root,COG0119@2|Bacteria,1MUNQ@1224|Proteobacteria,2VI4G@28216|Betaproteobacteria,44V3P@713636|Nitrosomonadales 28216|Betaproteobacteria H Belongs to the alpha-IPM synthase homocitrate synthase family leuA - 2.3.3.13 ko:K01649 ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230 M00432 R01213 RC00004,RC00470,RC02754 br01601,ko00000,ko00001,ko00002,ko01000 - - - HMGL-like,LeuA_dimer k59_290308_1 1280950.HJO_16040 3.18e-22 97.8 COG0726@1|root,COG0726@2|Bacteria,1MV3V@1224|Proteobacteria,2TR0I@28211|Alphaproteobacteria 28211|Alphaproteobacteria G Polysaccharide deacetylase - - - - - - - - - - - - - k59_64478_1 1448139.AI20_19375 1.91e-46 164.0 COG1195@1|root,COG1195@2|Bacteria,1MX8N@1224|Proteobacteria,1RN5P@1236|Gammaproteobacteria,1Y3VY@135624|Aeromonadales 135624|Aeromonadales L it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP recF - - ko:K03629 ko03440,map03440 - - - ko00000,ko00001,ko03400 - - - SMC_N k59_685062_1 402881.Plav_0264 5.48e-75 235.0 COG0796@1|root,COG0796@2|Bacteria,1NAI2@1224|Proteobacteria,2TSR7@28211|Alphaproteobacteria,1JNSR@119043|Rhodobiaceae 28211|Alphaproteobacteria M Provides the (R)-glutamate required for cell wall biosynthesis murI - 5.1.1.3 ko:K01776 ko00471,ko01100,map00471,map01100 - R00260 RC00302 ko00000,ko00001,ko01000,ko01011 - - - Asp_Glu_race k59_1419462_1 436308.Nmar_1310 2.99e-20 86.7 COG0518@1|root,arCOG00090@2157|Archaea,41T3Z@651137|Thaumarchaeota 651137|Thaumarchaeota F glutamine amidotransferase - - - - - - - - - - - - GATase k59_1419462_2 192952.MM_3077 7.81e-05 44.7 COG0589@1|root,arCOG02053@2157|Archaea,2XX8Y@28890|Euryarchaeota,2N9XS@224756|Methanomicrobia 224756|Methanomicrobia T Universal stress protein family - - - - - - - - - - - - Usp k59_120732_1 765911.Thivi_2219 2.7e-119 357.0 COG1502@1|root,COG1502@2|Bacteria,1MWUW@1224|Proteobacteria,1RPQG@1236|Gammaproteobacteria,1WXED@135613|Chromatiales 135613|Chromatiales I Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol - - - ko:K06131 ko00564,ko01100,map00564,map01100 - R07390 RC00017 ko00000,ko00001,ko01000 - - - PLDc_2,PLDc_N k59_521364_2 1168065.DOK_18330 8.13e-42 150.0 COG3346@1|root,COG3346@2|Bacteria,1MZUH@1224|Proteobacteria,1S8S0@1236|Gammaproteobacteria,1J6FD@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S SURF1-like protein surf1 - - ko:K14998 - - - - ko00000,ko03029 3.D.4.8 - - SURF1 k59_521364_3 1117647.M5M_12290 3.33e-21 85.5 2DQ1B@1|root,334B6@2|Bacteria,1NCBI@1224|Proteobacteria,1SCWY@1236|Gammaproteobacteria,1J7CK@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Protein of unknown function (DUF2909) - - - - - - - - - - - - DUF2909 k59_578407_2 317936.Nos7107_0284 1.17e-37 137.0 COG1801@1|root,COG1801@2|Bacteria,1G2CT@1117|Cyanobacteria,1HM1M@1161|Nostocales 1117|Cyanobacteria S Protein of unknown function DUF72 - - - - - - - - - - - - DUF72 k59_1143136_1 458817.Shal_1713 8.46e-121 357.0 COG0015@1|root,COG0015@2|Bacteria,1MV4B@1224|Proteobacteria,1RN93@1236|Gammaproteobacteria,2Q8QB@267890|Shewanellaceae 1236|Gammaproteobacteria F Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily purB - 4.3.2.2 ko:K01756 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048,M00049 R01083,R04559 RC00379,RC00444,RC00445 ko00000,ko00001,ko00002,ko01000 - - - ASL_C,Lyase_1 k59_804912_1 1279009.ADICEAN_00451 7.56e-61 209.0 COG2993@1|root,COG3278@1|root,COG2993@2|Bacteria,COG3278@2|Bacteria,4NEGM@976|Bacteroidetes,47MI5@768503|Cytophagia 976|Bacteroidetes C Belongs to the heme-copper respiratory oxidase family ccoN - 1.9.3.1 ko:K15862 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00156 - - ko00000,ko00001,ko00002,ko01000 3.D.4.3 - - COX1,FixO k59_1031214_1 1121035.AUCH01000017_gene2261 5.41e-34 122.0 COG2259@1|root,COG2259@2|Bacteria,1RDRZ@1224|Proteobacteria,2VS2G@28216|Betaproteobacteria,2KYXS@206389|Rhodocyclales 206389|Rhodocyclales S DoxX - - - ko:K15977 - - - - ko00000 - - - DoxX k59_804915_1 1283284.AZUK01000001_gene1666 4.51e-49 158.0 COG0099@1|root,COG0099@2|Bacteria,1RD1G@1224|Proteobacteria,1S3NX@1236|Gammaproteobacteria,1Y4C5@135624|Aeromonadales 135624|Aeromonadales J Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits rpsM - - ko:K02952 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S13 k59_296578_1 398578.Daci_0333 9.15e-90 277.0 COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2VHQD@28216|Betaproteobacteria,4AAXG@80864|Comamonadaceae 28216|Betaproteobacteria C PFAM Aldehyde dehydrogenase - - 1.2.1.3,1.2.1.8 ko:K00128,ko:K00130 ko00010,ko00053,ko00071,ko00260,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00260,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130 M00135,M00555 R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02565,R02566,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146 RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_239127_1 748658.KB907321_gene848 5.45e-37 130.0 COG1510@1|root,COG1510@2|Bacteria,1RA49@1224|Proteobacteria,1RRGB@1236|Gammaproteobacteria,1X08N@135613|Chromatiales 135613|Chromatiales K Bacterial regulatory protein, arsR family - - - - - - - - - - - - MarR_2 k59_1708025_1 1229909.NSED_00030 7.63e-151 451.0 COG1615@1|root,arCOG06128@2157|Archaea,41SCS@651137|Thaumarchaeota 651137|Thaumarchaeota S Uncharacterised protein family (UPF0182) - - - ko:K09118 - - - - ko00000 - - - UPF0182 k59_1031222_1 436308.Nmar_1455 4.34e-125 367.0 COG0015@1|root,arCOG01747@2157|Archaea,41SD1@651137|Thaumarchaeota 651137|Thaumarchaeota F adenylosuccinate lyase - - 4.3.2.2 ko:K01756 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048,M00049 R01083,R04559 RC00379,RC00444,RC00445 ko00000,ko00001,ko00002,ko01000 - - - ADSL_C,Lyase_1 k59_917362_1 1122137.AQXF01000003_gene2474 1.41e-92 281.0 COG0772@1|root,COG0772@2|Bacteria,1MUK3@1224|Proteobacteria,2TSM0@28211|Alphaproteobacteria 28211|Alphaproteobacteria M Peptidoglycan polymerase that is essential for cell wall elongation mrdB - - ko:K05837 - - - - ko00000,ko03036 - - - FTSW_RODA_SPOVE k59_1086744_1 395495.Lcho_2235 2.28e-05 52.8 COG0419@1|root,COG0419@2|Bacteria,1PFR7@1224|Proteobacteria,2WA2A@28216|Betaproteobacteria,1KMYD@119065|unclassified Burkholderiales 28216|Betaproteobacteria L Lambda phage tail tape-measure protein (Tape_meas_lam_C) - - - - - - - - - - - - Tape_meas_lam_C k59_1425587_1 760011.Spico_0269 6.97e-93 281.0 COG3842@1|root,COG3842@2|Bacteria,2J5T3@203691|Spirochaetes 203691|Spirochaetes P Belongs to the ABC transporter superfamily - - - ko:K10112 ko02010,map02010 M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1 - - ABC_tran,TOBE,TOBE_2 k59_408953_1 690850.Desaf_1595 1.13e-37 132.0 COG3238@1|root,COG3238@2|Bacteria,1N6ZC@1224|Proteobacteria,42TS3@68525|delta/epsilon subdivisions,2WQN1@28221|Deltaproteobacteria,2MCJM@213115|Desulfovibrionales 28221|Deltaproteobacteria S Putative inner membrane exporter, YdcZ - - - ko:K09936 ko02024,map02024 - - - ko00000,ko00001,ko02000 2.A.7.21 - - DMT_YdcZ k59_408953_2 1101195.Meth11DRAFT_0818 8.86e-42 152.0 COG3193@1|root,COG3193@2|Bacteria,1R215@1224|Proteobacteria,2W84F@28216|Betaproteobacteria,2KNX5@206350|Nitrosomonadales 206350|Nitrosomonadales S Haem-degrading - - - - - - - - - - - - Haem_degrading k59_1200038_1 1469557.JSWF01000046_gene222 3.23e-109 345.0 COG0060@1|root,COG0060@2|Bacteria,4NEYT@976|Bacteroidetes,1HX3Y@117743|Flavobacteriia 976|Bacteroidetes J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) ileS GO:0003674,GO:0003824,GO:0004812,GO:0004822,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006428,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.5 ko:K01870 ko00970,map00970 M00359,M00360 R03656 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,tRNA-synt_1 k59_1764808_1 517417.Cpar_1277 4.16e-25 102.0 COG1064@1|root,COG1064@2|Bacteria,1FERU@1090|Chlorobi 1090|Chlorobi C alcohol dehydrogenase - - 1.1.1.1 ko:K13953 ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220 - R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310 RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273 ko00000,ko00001,ko01000 - - - ADH_N k59_1764808_2 251221.35211153 5.76e-25 106.0 COG4805@1|root,COG4805@2|Bacteria,1GC38@1117|Cyanobacteria 1117|Cyanobacteria S Bacterial protein of unknown function (DUF885) - - - - - - - - - - - - DUF885 k59_1256343_1 1005395.CSV86_23719 1.52e-31 127.0 COG1752@1|root,COG4775@1|root,COG1752@2|Bacteria,COG4775@2|Bacteria,1MUM9@1224|Proteobacteria,1RRSK@1236|Gammaproteobacteria,1YV2D@136845|Pseudomonas putida group 1236|Gammaproteobacteria M Surface antigen variable number plpD - - ko:K07001 - - - - ko00000 - - - Bac_surface_Ag,POTRA,Patatin k59_578448_2 593105.S7A_20174 1.59e-17 82.8 COG1028@1|root,COG1028@2|Bacteria,1MVQW@1224|Proteobacteria,1RNY1@1236|Gammaproteobacteria,3VZX6@53335|Pantoea 1236|Gammaproteobacteria IQ Belongs to the short-chain dehydrogenases reductases (SDR) family budC - 1.1.1.304,1.1.1.76 ko:K03366 ko00650,map00650 - R02855,R02946,R03707,R09078,R10505 RC00205,RC00525 ko00000,ko00001,ko01000 - - - adh_short,adh_short_C2 k59_634915_1 1216976.AX27061_0508 1.07e-18 83.6 COG1633@1|root,COG1633@2|Bacteria,1MXX8@1224|Proteobacteria,2VI3H@28216|Betaproteobacteria,3T1DD@506|Alcaligenaceae 28216|Betaproteobacteria S Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME) - - - - - - - - - - - - - k59_634915_2 1000565.METUNv1_00290 4.42e-25 103.0 COG0789@1|root,COG5012@1|root,COG0789@2|Bacteria,COG5012@2|Bacteria,1R2NF@1224|Proteobacteria,2VJDG@28216|Betaproteobacteria,2KW35@206389|Rhodocyclales 206389|Rhodocyclales K B12 binding domain - - - ko:K22491 - - - - ko00000,ko03000 - - - B12-binding,B12-binding_2,MerR_1 k59_861989_2 1123279.ATUS01000001_gene2605 2.19e-20 99.8 COG4188@1|root,COG4188@2|Bacteria,1R6B7@1224|Proteobacteria,1RZ88@1236|Gammaproteobacteria,1J86U@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Platelet-activating factor acetylhydrolase, isoform II - - - - - - - - - - - - PAF-AH_p_II k59_1595294_1 207954.MED92_10544 5.1e-32 119.0 COG3216@1|root,COG3216@2|Bacteria,1RGV6@1224|Proteobacteria,1S682@1236|Gammaproteobacteria,1XJZU@135619|Oceanospirillales 135619|Oceanospirillales S protein conserved in bacteria - - - ko:K09928 - - - - ko00000 - - - DUF2062 k59_1369978_1 565045.NOR51B_2789 7.34e-87 268.0 COG0372@1|root,COG0372@2|Bacteria,1MUKX@1224|Proteobacteria,1RNDK@1236|Gammaproteobacteria,1J4ZB@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Belongs to the citrate synthase family gltA GO:0003674,GO:0003824,GO:0004108,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016740,GO:0016746,GO:0016999,GO:0017144,GO:0019752,GO:0036440,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0046912,GO:0055114,GO:0071704,GO:0072350 2.3.3.1 ko:K01647 ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00740 R00351 RC00004,RC00067 br01601,ko00000,ko00001,ko00002,ko01000 - - iYL1228.KPN_00727 Citrate_synt k59_861995_1 402626.Rpic_4407 2.68e-22 100.0 COG1306@1|root,COG1306@2|Bacteria,1MWBY@1224|Proteobacteria,2VPH9@28216|Betaproteobacteria,1K3VS@119060|Burkholderiaceae 28216|Betaproteobacteria S Putative glycosyl hydrolase domain - - - - - - - - - - - - DUF4015 k59_1539276_1 745014.OMB55_00006780 1.15e-55 181.0 COG1028@1|root,COG1028@2|Bacteria,1QDWF@1224|Proteobacteria,1RR7J@1236|Gammaproteobacteria 1236|Gammaproteobacteria IQ KR domain - - - - - - - - - - - - adh_short_C2 k59_465378_1 436308.Nmar_1709 1.03e-193 549.0 COG0661@1|root,arCOG01189@2157|Archaea,41SYQ@651137|Thaumarchaeota 651137|Thaumarchaeota S ABC1 family - - - - - - - - - - - - ABC1 k59_1200065_1 1122137.AQXF01000001_gene2925 7.91e-100 296.0 COG0670@1|root,COG0670@2|Bacteria,1MU69@1224|Proteobacteria,2TRSF@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Belongs to the BI1 family - - - ko:K06890 - - - - ko00000 - - - Bax1-I k59_1483346_1 1229909.NSED_01490 8.85e-57 186.0 COG0454@1|root,arCOG00845@2157|Archaea,41T5Q@651137|Thaumarchaeota 651137|Thaumarchaeota K Acetyltransferase (GNAT) family - - - - - - - - - - - - Acetyltransf_1 k59_239187_1 215803.DB30_6876 1.25e-45 179.0 COG1858@1|root,COG2706@1|root,COG3391@1|root,COG1858@2|Bacteria,COG2706@2|Bacteria,COG3391@2|Bacteria,1R66T@1224|Proteobacteria,439FZ@68525|delta/epsilon subdivisions,2X4RS@28221|Deltaproteobacteria,2YZGC@29|Myxococcales 28221|Deltaproteobacteria G 6-phosphogluconolactonase activity - - - - - - - - - - - - Lactonase k59_1483357_1 1415778.JQMM01000001_gene1950 7.9e-30 122.0 COG4783@1|root,COG4783@2|Bacteria,1QTUQ@1224|Proteobacteria,1T1HY@1236|Gammaproteobacteria,1JC1V@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Oxygen tolerance batD - - - - - - - - - - - BatD k59_1425636_1 436308.Nmar_1665 2.64e-24 97.4 COG3794@1|root,arCOG02926@2157|Archaea 2157|Archaea C PFAM blue (type 1) copper domain protein - - - - - - - - - - - - Copper-bind,Cupredoxin_1 k59_1595316_1 1229909.NSED_09775 4.13e-48 158.0 arCOG08814@1|root,arCOG08814@2157|Archaea,41T9Z@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1764831_1 247490.KSU1_C1392 1.58e-23 107.0 COG1032@1|root,COG1032@2|Bacteria,2IYYP@203682|Planctomycetes 203682|Planctomycetes C B12 binding domain - - - - - - - - - - - - B12-binding,DUF4070,Radical_SAM k59_1256368_1 1000565.METUNv1_01808 2.23e-47 170.0 COG0659@1|root,COG0659@2|Bacteria,1MWDF@1224|Proteobacteria,2VHKJ@28216|Betaproteobacteria,2KXV8@206389|Rhodocyclales 206389|Rhodocyclales U Sulfate permease family - - - - - - - - - - - - Sulfate_transp k59_1086812_1 1121439.dsat_0193 6.87e-83 266.0 COG0145@1|root,COG0145@2|Bacteria,1MU2Y@1224|Proteobacteria,42NFP@68525|delta/epsilon subdivisions,2WK64@28221|Deltaproteobacteria,2M9T7@213115|Desulfovibrionales 28221|Deltaproteobacteria EQ PFAM Hydantoinase oxoprolinase hyuA - 3.5.2.14 ko:K01473 ko00330,ko01100,map00330,map01100 - R03187 RC00632 ko00000,ko00001,ko01000 - - - Hydant_A_N,Hydantoinase_A k59_1539285_2 379066.GAU_2550 4.76e-62 204.0 COG0491@1|root,COG0607@1|root,COG0491@2|Bacteria,COG0607@2|Bacteria,1ZT0Y@142182|Gemmatimonadetes 142182|Gemmatimonadetes P Rhodanese Homology Domain - - 3.1.2.6 ko:K01069 ko00620,map00620 - R01736 RC00004,RC00137 ko00000,ko00001,ko01000 - - - Lactamase_B,Rhodanese k59_1086824_1 1239962.C943_04277 1.78e-60 195.0 COG1028@1|root,COG1028@2|Bacteria,4NGQY@976|Bacteroidetes 976|Bacteroidetes IQ Short-chain dehydrogenase reductase sdr - - 1.1.1.53 ko:K00038 ko00140,ko01100,map00140,map01100 - R04831,R04834,R04844,R04847 RC00139,RC01219,RC01220 ko00000,ko00001,ko01000 - - - adh_short_C2 k59_239198_1 1268303.RHODMAR_0516 0.000119 49.3 COG0204@1|root,COG0560@1|root,COG0204@2|Bacteria,COG0560@2|Bacteria,2GJVX@201174|Actinobacteria,4FUIH@85025|Nocardiaceae 201174|Actinobacteria EI Phosphate acyltransferases plsC - 2.3.1.51,3.1.3.3 ko:K00655,ko:K15781 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R02241,R09381 RC00004,RC00037,RC00039 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Acyltransferase,HAD k59_1708113_1 1123276.KB893272_gene2436 6.76e-57 192.0 COG3385@1|root,COG3385@2|Bacteria,4P02Y@976|Bacteroidetes,47TUA@768503|Cytophagia 976|Bacteroidetes L Transposase DDE domain - - - - - - - - - - - - DDE_Tnp_1 k59_70858_1 1121937.AUHJ01000006_gene2541 2.81e-28 111.0 COG3748@1|root,COG3748@2|Bacteria,1RFIZ@1224|Proteobacteria,1S8F8@1236|Gammaproteobacteria,46AQ1@72275|Alteromonadaceae 1236|Gammaproteobacteria S Urate oxidase N-terminal - - - - - - - - - - - - Urate_ox_N k59_1200081_1 1121861.KB899934_gene490 1.44e-102 303.0 COG0410@1|root,COG0410@2|Bacteria,1MVVC@1224|Proteobacteria,2TSCA@28211|Alphaproteobacteria,2JVBF@204441|Rhodospirillales 204441|Rhodospirillales E ATPases associated with a variety of cellular activities - - - ko:K01996 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - ABC_tran k59_1086835_1 391615.ABSJ01000026_gene91 4.39e-46 162.0 COG4399@1|root,COG4399@2|Bacteria,1R42C@1224|Proteobacteria,1RPWG@1236|Gammaproteobacteria 1236|Gammaproteobacteria S protein conserved in bacteria - - - - - - - - - - - - DUF445 k59_1652241_1 84531.JMTZ01000041_gene668 4.03e-21 98.2 COG1529@1|root,COG1529@2|Bacteria,1QTTJ@1224|Proteobacteria,1RNCM@1236|Gammaproteobacteria,1X5E5@135614|Xanthomonadales 135614|Xanthomonadales C Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL - - 1.3.99.16 ko:K07303 - - - - ko00000,ko01000 - - - Ald_Xan_dh_C2,TAT_signal k59_578485_1 1175306.GWL_29750 3.39e-67 227.0 COG0013@1|root,COG0013@2|Bacteria,1MU9A@1224|Proteobacteria,2VH6Z@28216|Betaproteobacteria,47292@75682|Oxalobacteraceae 28216|Betaproteobacteria J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain alaS - 6.1.1.7 ko:K01872 ko00970,map00970 M00359,M00360 R03038 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DHHA1,tRNA-synt_2c,tRNA_SAD k59_747653_1 338963.Pcar_0024 1.39e-123 364.0 COG0451@1|root,COG0451@2|Bacteria,1MVE4@1224|Proteobacteria,42MC1@68525|delta/epsilon subdivisions,2WJ24@28221|Deltaproteobacteria,43UKS@69541|Desulfuromonadales 28221|Deltaproteobacteria F Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose hldD - 5.1.3.20 ko:K03274 ko00540,ko01100,map00540,map01100 M00064 R05176 RC01291 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Epimerase k59_521457_1 177439.DP1118 4.6e-114 362.0 COG0086@1|root,COG0086@2|Bacteria,1MU3M@1224|Proteobacteria,42NAW@68525|delta/epsilon subdivisions,2WISU@28221|Deltaproteobacteria,2MIYJ@213118|Desulfobacterales 28221|Deltaproteobacteria K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoC - 2.7.7.6 ko:K03046 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5 k59_70866_1 1185652.USDA257_c28430 3.91e-05 48.5 COG0790@1|root,COG4249@1|root,COG0790@2|Bacteria,COG4249@2|Bacteria,1MXFD@1224|Proteobacteria,2TRW5@28211|Alphaproteobacteria,4BARN@82115|Rhizobiaceae 28211|Alphaproteobacteria S Caspase domain - - - ko:K07126 - - - - ko00000 - - - PG_binding_1,Peptidase_C14,Sel1 k59_691489_1 1232683.ADIMK_0655 1.8e-45 162.0 COG4536@1|root,COG4536@2|Bacteria,1NZ99@1224|Proteobacteria,1RNCE@1236|Gammaproteobacteria,464AQ@72275|Alteromonadaceae 1236|Gammaproteobacteria P Mg2 and Co2 transporter CorB yfjD GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - - - - - - - - - - CBS,CorC_HlyC,DUF21 k59_578490_2 1229909.NSED_01305 8.58e-117 334.0 COG1143@1|root,arCOG01543@2157|Archaea,41SGW@651137|Thaumarchaeota 651137|Thaumarchaeota C 4Fe-4S binding domain - - 1.6.5.3 ko:K00338 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Fer4,Fer4_4 k59_578490_3 436308.Nmar_0282 4.65e-26 100.0 COG0839@1|root,arCOG04654@2157|Archaea,41SM8@651137|Thaumarchaeota 651137|Thaumarchaeota C PFAM NADH-ubiquinone plastoquinone oxidoreductase chain 6 - - 1.6.5.3 ko:K00339 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q3 k59_521463_1 472759.Nhal_2383 1.95e-107 319.0 COG0050@1|root,COG0050@2|Bacteria,1MVC0@1224|Proteobacteria,1RMYX@1236|Gammaproteobacteria,1WWIK@135613|Chromatiales 135613|Chromatiales J This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis tuf - - ko:K02358 - - - - ko00000,ko03012,ko03029,ko04147 - - - GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3 k59_1539310_1 1265503.KB905164_gene1780 3.46e-32 124.0 COG0760@1|root,COG0760@2|Bacteria,1NUDI@1224|Proteobacteria,1SNJZ@1236|Gammaproteobacteria 1236|Gammaproteobacteria O PPIC-type PPIASE domain - - - - - - - - - - - - Rotamase_2 k59_353173_2 700508.D174_09390 1.03e-11 65.9 COG2141@1|root,COG2141@2|Bacteria,2GNE9@201174|Actinobacteria,234QW@1762|Mycobacteriaceae 201174|Actinobacteria C F420-dependent oxidoreductase - - - - - - - - - - - - Bac_luciferase k59_747666_1 702113.PP1Y_Mpl10285 0.00028 44.3 COG1234@1|root,COG1234@2|Bacteria,1R8R4@1224|Proteobacteria,2TVHT@28211|Alphaproteobacteria,2K1U2@204457|Sphingomonadales 204457|Sphingomonadales S Beta-lactamase superfamily domain - - - - - - - - - - - - Lactamase_B_2 k59_747666_2 1123073.KB899243_gene474 1.05e-84 252.0 COG3558@1|root,COG3558@2|Bacteria,1RA64@1224|Proteobacteria,1S252@1236|Gammaproteobacteria,1X6BN@135614|Xanthomonadales 135614|Xanthomonadales S Protein of unknown function (DUF1348) - - - ko:K09958 - - - - ko00000 - - - DUF1348 k59_973075_2 706587.Desti_1616 4.68e-16 79.3 COG1595@1|root,COG1595@2|Bacteria,1MX7T@1224|Proteobacteria,42V72@68525|delta/epsilon subdivisions,2WRHE@28221|Deltaproteobacteria,2MSA6@213462|Syntrophobacterales 28221|Deltaproteobacteria K Belongs to the sigma-70 factor family. ECF subfamily - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 k59_1313510_1 1122137.AQXF01000002_gene486 1.05e-115 338.0 COG4221@1|root,COG4221@2|Bacteria,1MW86@1224|Proteobacteria,2TSEM@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Belongs to the short-chain dehydrogenases reductases (SDR) family MA20_04540 - - - - - - - - - - - adh_short k59_1313510_2 1122137.AQXF01000002_gene485 4.22e-53 173.0 COG1028@1|root,COG1028@2|Bacteria,1MWGC@1224|Proteobacteria,2TSNX@28211|Alphaproteobacteria 28211|Alphaproteobacteria IQ short-chain dehydrogenase - - - - - - - - - - - - adh_short,adh_short_C2 k59_70886_1 1121378.KB899700_gene1938 4.33e-44 155.0 COG1088@1|root,COG1088@2|Bacteria,1WJHN@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus M Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily - - 4.2.1.46 ko:K01710 ko00521,ko00523,ko00525,ko01055,ko01130,map00521,map00523,map00525,map01055,map01130 M00793 R06513 RC00402 ko00000,ko00001,ko00002,ko01000 - - - GDP_Man_Dehyd k59_70886_2 1123502.AQXD01000001_gene620 3.72e-11 65.1 COG0593@1|root,COG0593@2|Bacteria,1MU5H@1224|Proteobacteria,1RNHP@1236|Gammaproteobacteria,1X424@135614|Xanthomonadales 135614|Xanthomonadales L it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids dnaA GO:0003674,GO:0003676,GO:0003677,GO:0003688,GO:0003690,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0034641,GO:0034645,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901576,GO:1990837 - ko:K02313 ko02020,ko04112,map02020,map04112 - - - ko00000,ko00001,ko03032,ko03036 - - - Bac_DnaA,Bac_DnaA_C,DnaA_N k59_465416_1 1442599.JAAN01000043_gene482 1.92e-47 164.0 COG2115@1|root,COG2115@2|Bacteria,1MXS2@1224|Proteobacteria,1RN5Y@1236|Gammaproteobacteria,1X4B9@135614|Xanthomonadales 135614|Xanthomonadales G Belongs to the xylose isomerase family xylA GO:0003674,GO:0003824,GO:0005975,GO:0005996,GO:0008150,GO:0008152,GO:0009045,GO:0009056,GO:0016052,GO:0016853,GO:0016860,GO:0016861,GO:0019321,GO:0019323,GO:0042732,GO:0042843,GO:0044238,GO:0044281,GO:0044282,GO:0046365,GO:0071704,GO:1901575 5.3.1.5 ko:K01805 ko00040,ko00051,ko01100,map00040,map00051,map01100 - R00878,R01432 RC00376,RC00516 ko00000,ko00001,ko01000 - - - - k59_465416_2 1211114.ALIP01000029_gene2571 1.53e-23 100.0 COG1070@1|root,COG1070@2|Bacteria,1MW4A@1224|Proteobacteria,1RR7X@1236|Gammaproteobacteria,1X4TN@135614|Xanthomonadales 135614|Xanthomonadales G Xylulose kinase xylB - 2.7.1.17 ko:K00854 ko00040,ko01100,map00040,map01100 M00014 R01639 RC00002,RC00538 ko00000,ko00001,ko00002,ko01000 - - - FGGY_C,FGGY_N k59_1370049_2 1231392.OCGS_2807 2.11e-92 281.0 COG0182@1|root,COG0182@2|Bacteria,1MUPM@1224|Proteobacteria,2TSPP@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P) mtnA - 5.3.1.23 ko:K08963 ko00270,ko01100,map00270,map01100 M00034 R04420 RC01151 ko00000,ko00001,ko00002,ko01000 - - - IF-2B k59_127027_1 326427.Cagg_2559 7.32e-22 92.8 COG2135@1|root,COG2135@2|Bacteria,2G74X@200795|Chloroflexi,377BN@32061|Chloroflexia 32061|Chloroflexia S Belongs to the SOS response-associated peptidase family - - - - - - - - - - - - SRAP k59_636117_1 1229780.BN381_130019 6.06e-199 578.0 COG0046@1|root,COG0046@2|Bacteria,2GKG6@201174|Actinobacteria,3UWF7@52018|unclassified Actinobacteria (class) 201174|Actinobacteria F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL purL GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009987,GO:0018130,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.5.3 ko:K01952 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04463 RC00010,RC01160 ko00000,ko00001,ko00002,ko01000 - - - AIRS,AIRS_C k59_1314632_1 167548.EU98_1805 1.6e-35 144.0 28JA7@1|root,2Z951@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - CotH k59_806118_1 1229909.NSED_03770 3.68e-13 67.4 arCOG08757@1|root,arCOG08757@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_748902_1 679926.Mpet_0506 1.2e-13 73.6 COG0213@1|root,arCOG02013@2157|Archaea,2XT19@28890|Euryarchaeota,2N9C6@224756|Methanomicrobia 224756|Methanomicrobia F Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO deoA - 2.4.2.57 ko:K18931 - - R10836,R10837,R10838 RC00063 ko00000,ko01000 - - - Glycos_trans_3N,Glycos_transf_3,Molydop_binding,PYNP_C k59_748902_2 1131266.ARWQ01000001_gene1349 2.68e-32 122.0 COG0462@1|root,arCOG00067@2157|Archaea,41SH1@651137|Thaumarchaeota 651137|Thaumarchaeota F Ribose-phosphate pyrophosphokinase - - 2.7.6.1 ko:K00948 ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230 M00005 R01049 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - Pribosyl_synth,Pribosyltran,Pribosyltran_N k59_128195_1 56110.Oscil6304_3538 7.49e-26 111.0 COG5421@1|root,COG5421@2|Bacteria,1G4EU@1117|Cyanobacteria,1H9I9@1150|Oscillatoriales 1117|Cyanobacteria L IMG reference gene - - - - - - - - - - - - DDE_Tnp_1 k59_869691_1 91464.S7335_5495 3.97e-10 65.9 COG1957@1|root,COG1957@2|Bacteria,1G231@1117|Cyanobacteria,1GZ4T@1129|Synechococcus 1117|Cyanobacteria F Inosine-uridine preferring nucleoside hydrolase family protein - - 3.2.2.1 ko:K01239,ko:K01250 ko00230,ko00760,ko01100,map00230,map00760,map01100 - R01245,R01273,R01677,R01770,R02143 RC00033,RC00063,RC00122,RC00318,RC00485 ko00000,ko00001,ko01000 - - - IU_nuc_hydro k59_869691_2 313606.M23134_05675 3.82e-87 275.0 COG4770@1|root,COG4770@2|Bacteria,4NM1W@976|Bacteroidetes,47M7U@768503|Cytophagia 976|Bacteroidetes I PFAM Carbamoyl-phosphate synthase L chain, ATP binding - - 6.3.4.14,6.4.1.2,6.4.1.3 ko:K01961,ko:K01965 ko00061,ko00280,ko00620,ko00630,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00280,map00620,map00630,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00373,M00376,M00741 R00742,R01859,R04385 RC00040,RC00097,RC00253,RC00367,RC00609 ko00000,ko00001,ko00002,ko01000 - - - Biotin_carb_C,Biotin_carb_N,CPSase_L_D2 k59_1377815_1 555793.WSK_3695 8.52e-103 303.0 COG1250@1|root,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,2TR8E@28211|Alphaproteobacteria,2K0X2@204457|Sphingomonadales 204457|Sphingomonadales I Dehydrogenase paaH - 1.1.1.157 ko:K00074 ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120 - R01976,R05576,R06941 RC00029,RC00117 ko00000,ko00001,ko01000 - - - 3HCDH,3HCDH_N k59_586091_2 582402.Hbal_1417 7.76e-117 364.0 COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,2TQK9@28211|Alphaproteobacteria,43WY6@69657|Hyphomonadaceae 28211|Alphaproteobacteria L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate uvrA - - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - ABC_tran k59_1547178_1 693986.MOC_0603 1.87e-41 151.0 COG3202@1|root,COG3202@2|Bacteria,1MVP5@1224|Proteobacteria,2U1N0@28211|Alphaproteobacteria,1JRBF@119045|Methylobacteriaceae 28211|Alphaproteobacteria C ATP ADP translocase - - - ko:K03301 - - - - ko00000 2.A.12 - - MFS_1,TLC k59_1547178_2 1100720.ALKN01000052_gene507 7.8e-33 124.0 COG2271@1|root,COG2271@2|Bacteria,1QTW2@1224|Proteobacteria 1224|Proteobacteria G Major facilitator Superfamily MA20_02120 - - - - - - - - - - - MFS_1 k59_1547187_1 765910.MARPU_07330 3.21e-12 64.3 COG0806@1|root,COG0806@2|Bacteria,1MWQR@1224|Proteobacteria,1RNJ2@1236|Gammaproteobacteria,1WY0M@135613|Chromatiales 135613|Chromatiales J An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes rimM - - ko:K02860 - - - - ko00000,ko03009 - - - PRC,RimM k59_1547187_2 1120970.AUBZ01000003_gene33 6.38e-36 123.0 COG0228@1|root,COG0228@2|Bacteria,1MZCT@1224|Proteobacteria,1S8RT@1236|Gammaproteobacteria,467U2@72275|Alteromonadaceae 1236|Gammaproteobacteria J Belongs to the bacterial ribosomal protein bS16 family rpsP GO:0000028,GO:0000217,GO:0000400,GO:0003674,GO:0003676,GO:0003677,GO:0003735,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006259,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0016787,GO:0016788,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02959 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011,ko03029 - - - Ribosomal_S16 k59_304558_2 1246995.AFR_08775 1.55e-40 144.0 COG1277@1|root,COG1277@2|Bacteria,2ID14@201174|Actinobacteria,4DCGZ@85008|Micromonosporales 201174|Actinobacteria S ABC-2 family transporter protein - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_2 k59_586107_1 1122137.AQXF01000003_gene2187 2.01e-111 340.0 COG1298@1|root,COG1298@2|Bacteria,1MUF3@1224|Proteobacteria,2TQUR@28211|Alphaproteobacteria 28211|Alphaproteobacteria N Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin flhA - - ko:K02400 ko02040,map02040 - - - ko00000,ko00001,ko02035,ko02044 3.A.6.2,3.A.6.3 - - FHIPEP k59_586107_2 1122137.AQXF01000003_gene2186 8.17e-08 53.1 COG1419@1|root,COG1419@2|Bacteria,1MUQW@1224|Proteobacteria,2U06N@28211|Alphaproteobacteria 28211|Alphaproteobacteria N COG1419 Flagellar GTP-binding protein flhF - - ko:K02404 - - - - ko00000,ko02035 - - - SRP54 k59_1432917_1 1298863.AUEP01000014_gene1712 9.04e-69 232.0 COG1048@1|root,COG1048@2|Bacteria,2GJD5@201174|Actinobacteria,4DPP4@85009|Propionibacteriales 201174|Actinobacteria C Catalyzes the isomerization of citrate to isocitrate via cis-aconitate acnA GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003730,GO:0003824,GO:0003994,GO:0005488,GO:0005506,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005829,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0008198,GO:0009060,GO:0009987,GO:0010035,GO:0010038,GO:0010039,GO:0015980,GO:0016020,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017144,GO:0019541,GO:0019679,GO:0019752,GO:0030312,GO:0030350,GO:0032787,GO:0040007,GO:0042221,GO:0043167,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0046459,GO:0046872,GO:0046914,GO:0047456,GO:0048037,GO:0050896,GO:0051536,GO:0051538,GO:0051539,GO:0051540,GO:0055114,GO:0071704,GO:0071944,GO:0072350,GO:0097159,GO:1901363 4.2.1.3 ko:K01681 ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00173,M00740 R01324,R01325,R01900 RC00497,RC00498,RC00618 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase,Aconitase_C k59_1603315_1 383381.EH30_14390 3.23e-54 177.0 COG0225@1|root,COG0225@2|Bacteria,1NC84@1224|Proteobacteria,2TTDD@28211|Alphaproteobacteria,2K3XP@204457|Sphingomonadales 204457|Sphingomonadales O Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine msrA_1 - 1.8.4.11 ko:K07304 - - - - ko00000,ko01000 - - - PMSR k59_134496_1 1229909.NSED_05425 5.24e-61 191.0 COG3620@1|root,arCOG00608@2157|Archaea,41SJR@651137|Thaumarchaeota 651137|Thaumarchaeota K Helix-turn-helix XRE-family like proteins - - - - - - - - - - - - CBS,HTH_3 k59_134496_2 436308.Nmar_0951 3.57e-12 65.5 COG0574@1|root,arCOG01111@2157|Archaea,41SYV@651137|Thaumarchaeota 651137|Thaumarchaeota G Pyruvate phosphate dikinase - - 2.7.9.1 ko:K01006 ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200 M00169,M00171,M00172,M00173 R00206 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - PEP-utilizers,PEP-utilizers_C,PPDK_N k59_1094169_1 309807.SRU_1123 1.37e-29 122.0 COG0031@1|root,COG3620@1|root,COG0031@2|Bacteria,COG3620@2|Bacteria,4NDZ9@976|Bacteroidetes,1FK12@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes E Pyridoxal-phosphate dependent enzyme - - 4.2.1.22 ko:K01697 ko00260,ko00270,ko01100,ko01130,ko01230,map00260,map00270,map01100,map01130,map01230 M00035,M00338 R00891,R01290,R04942 RC00056,RC00069,RC00256,RC00489,RC01246 ko00000,ko00001,ko00002,ko01000 - - - CBS,PALP k59_1094169_2 414684.RC1_0561 1.89e-10 58.9 COG0425@1|root,COG0425@2|Bacteria,1MZA5@1224|Proteobacteria,2UF3C@28211|Alphaproteobacteria,2JU9S@204441|Rhodospirillales 204441|Rhodospirillales O Belongs to the sulfur carrier protein TusA family - - - ko:K04085 ko04122,map04122 - - - ko00000,ko00001,ko01000,ko03016 - - - TusA k59_1094169_3 547144.HydHO_1079 9.49e-28 107.0 COG2210@1|root,COG2210@2|Bacteria,2G565@200783|Aquificae 200783|Aquificae S DsrE/DsrF/DrsH-like family - - - - - - - - - - - - DrsE_2 k59_1263281_2 338963.Pcar_0394 7.06e-22 95.5 COG2165@1|root,COG2165@2|Bacteria,1RK34@1224|Proteobacteria,42Y1S@68525|delta/epsilon subdivisions,2WTH8@28221|Deltaproteobacteria,43U7J@69541|Desulfuromonadales 28221|Deltaproteobacteria NU Prokaryotic N-terminal methylation motif - - - ko:K12285 - - - - ko00000,ko02044 - - - N_methyl k59_755113_1 640132.Srot_2152 5.81e-77 244.0 COG0213@1|root,COG0213@2|Bacteria,2GJH5@201174|Actinobacteria 201174|Actinobacteria F phosphorylase deoA GO:0003674,GO:0003824,GO:0004645,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0009032,GO:0016740,GO:0016757,GO:0016758,GO:0016763,GO:0044424,GO:0044444,GO:0044464 2.4.2.2,2.4.2.4 ko:K00756,ko:K00758 ko00240,ko00983,ko01100,ko05219,map00240,map00983,map01100,map05219 - R01570,R01876,R02296,R02484,R08222,R08230 RC00063 ko00000,ko00001,ko01000 - - - Glycos_trans_3N,Glycos_transf_3,PYNP_C k59_190856_2 983920.Y88_2864 1.39e-88 270.0 COG1957@1|root,COG1957@2|Bacteria,1MUIW@1224|Proteobacteria,2TSXQ@28211|Alphaproteobacteria,2KBDZ@204457|Sphingomonadales 204457|Sphingomonadales F Inosine-uridine preferring nucleoside hydrolase - - - - - - - - - - - - IU_nuc_hydro k59_642259_1 83406.HDN1F_03210 2.2e-72 229.0 COG0263@1|root,COG0263@2|Bacteria,1MUBG@1224|Proteobacteria,1RM7X@1236|Gammaproteobacteria,1J4MT@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate proB GO:0000287,GO:0003674,GO:0003824,GO:0004349,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016597,GO:0016740,GO:0016772,GO:0016774,GO:0017144,GO:0018130,GO:0019202,GO:0019752,GO:0031406,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046872,GO:0055129,GO:0071704,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1901973 2.7.2.11 ko:K00931 ko00330,ko00332,ko01100,ko01130,ko01230,map00330,map00332,map01100,map01130,map01230 M00015 R00239 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase,PUA k59_1377857_1 221288.JH992901_gene2720 3.53e-83 260.0 COG1012@1|root,COG1012@2|Bacteria,1G09W@1117|Cyanobacteria,1JHZW@1189|Stigonemataceae 1117|Cyanobacteria C Aldehyde dehydrogenase family - - 1.2.1.18,1.2.1.27 ko:K00140 ko00280,ko00410,ko00562,ko00640,ko01100,ko01200,map00280,map00410,map00562,map00640,map01100,map01200 M00013 R00705,R00706,R00922,R00935 RC00004,RC02723,RC02817 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_1377857_2 696369.KI912183_gene2506 0.000213 43.9 COG2414@1|root,COG2414@2|Bacteria,1TPT9@1239|Firmicutes,2481Q@186801|Clostridia,260VN@186807|Peptococcaceae 186801|Clostridia C Aldehyde ferredoxin - - 1.2.7.5 ko:K03738 ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200 M00309 R08571 RC00242 ko00000,ko00001,ko00002,ko01000 - - - AFOR_C,AFOR_N k59_586139_1 710686.Mycsm_05377 2.33e-62 204.0 COG1804@1|root,COG1804@2|Bacteria,2GIU7@201174|Actinobacteria,233ZH@1762|Mycobacteriaceae 201174|Actinobacteria C L-carnitine dehydratase bile acid-inducible protein F - - - - - - - - - - - - CoA_transf_3 k59_134527_1 649831.L083_7865 1.63e-07 57.8 COG1732@1|root,COG1732@2|Bacteria,2GJWY@201174|Actinobacteria,4D8WV@85008|Micromonosporales 201174|Actinobacteria M Substrate-binding region of ABC-type glycine betaine transport system - - - ko:K05845 ko02010,map02010 M00209 - - ko00000,ko00001,ko00002,ko02000 3.A.1.12 - - OpuAC k59_78991_1 1280953.HOC_20693 1.8e-35 132.0 COG2801@1|root,COG2801@2|Bacteria,1MWNX@1224|Proteobacteria,2TZ7M@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Integrase core domain - - - - - - - - - - - - LZ_Tnp_IS481,rve,rve_3 k59_1716195_1 105559.Nwat_2060 5.98e-23 99.8 COG2982@1|root,COG2982@2|Bacteria,1N0N6@1224|Proteobacteria,1SF4A@1236|Gammaproteobacteria,1X1M1@135613|Chromatiales 135613|Chromatiales M Protein involved in outer membrane biogenesis - - - - - - - - - - - - - k59_1771935_1 1122137.AQXF01000003_gene2197 1.35e-46 174.0 COG3144@1|root,COG3144@2|Bacteria 2|Bacteria N bacterial-type flagellum assembly fliK - - ko:K02414,ko:K10565 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - Flg_hook k59_642286_1 1033734.CAET01000025_gene1103 6.21e-14 71.6 COG2309@1|root,COG2309@2|Bacteria,1TP65@1239|Firmicutes,4H9W8@91061|Bacilli,1ZCU3@1386|Bacillus 91061|Bacilli E COG2309 Leucyl aminopeptidase (aminopeptidase T) ampS - - ko:K19689 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M29 k59_642286_2 1530186.JQEY01000014_gene214 1.73e-20 92.8 COG0346@1|root,COG0346@2|Bacteria,1RD81@1224|Proteobacteria,2U7VR@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Glyoxalase-like domain - - - - - - - - - - - - Glyoxalase_3 k59_755138_2 436308.Nmar_0428 2.23e-48 159.0 COG0202@1|root,arCOG04241@2157|Archaea,41SK0@651137|Thaumarchaeota 651137|Thaumarchaeota K DNA-directed RNA polymerase, alpha subunit 40 kD subunit - - 2.7.7.6 ko:K03047 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00184 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021 - - - RNA_pol_A_bac,RNA_pol_L k59_190885_1 1280950.HJO_15953 2.82e-59 198.0 COG1680@1|root,COG1680@2|Bacteria,1MVPR@1224|Proteobacteria,2TRWZ@28211|Alphaproteobacteria,43WQS@69657|Hyphomonadaceae 28211|Alphaproteobacteria V COG1680 Beta-lactamase class C and other penicillin binding proteins - - - - - - - - - - - - Beta-lactamase k59_869783_1 110319.CF8_1098 2.2e-11 66.2 COG2891@1|root,COG2891@2|Bacteria,2GN0I@201174|Actinobacteria,4DRR5@85009|Propionibacteriales 201174|Actinobacteria M rod shape-determining protein (MreD) mreD - - ko:K03571 - - - - ko00000,ko03036 9.B.157.1 - - MreD k59_1547257_1 637905.SVI_1520 2.06e-41 157.0 COG1629@1|root,COG1629@2|Bacteria,1MV8W@1224|Proteobacteria,1RQEQ@1236|Gammaproteobacteria,2QEKH@267890|Shewanellaceae 1236|Gammaproteobacteria P TonB-dependent receptor plug - - - - - - - - - - - - Plug,TonB_dep_Rec k59_1432963_1 436308.Nmar_0475 2.49e-35 129.0 COG1131@1|root,arCOG00194@2157|Archaea,41TB9@651137|Thaumarchaeota 651137|Thaumarchaeota V Domain of unknown function (DUF4162) - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran,DUF4162 k59_755140_2 1411123.JQNH01000001_gene3164 2.17e-19 87.8 COG3181@1|root,COG3181@2|Bacteria,1NBGQ@1224|Proteobacteria,2U3YX@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Tripartite tricarboxylate transporter family receptor - - - - - - - - - - - - TctC k59_528465_1 362663.ECP_0810 3.56e-75 229.0 COG1309@1|root,COG1309@2|Bacteria,1NDME@1224|Proteobacteria,1RQQB@1236|Gammaproteobacteria,3XNKM@561|Escherichia 1236|Gammaproteobacteria K Transcriptional regulator ybiH GO:0003674,GO:0003700,GO:0005488,GO:0005515,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0031333,GO:0031334,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0042802,GO:0043170,GO:0043254,GO:0044087,GO:0044089,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0046483,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051129,GO:0051130,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901576,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:2000112,GO:2000113,GO:2000142,GO:2000143,GO:2000144,GO:2001141 - - - - - - - - - - DUF1956,TetR_N k59_1150972_1 497321.C664_15668 2.01e-61 201.0 COG3384@1|root,COG3384@2|Bacteria,1MW77@1224|Proteobacteria,2VI4U@28216|Betaproteobacteria 28216|Betaproteobacteria S PFAM Extradiol ring-cleavage dioxygenase class III protein subunit B ligB - 1.13.11.57 ko:K04099 ko00627,ko01120,map00627,map01120 - R03550,R04280,R09565 RC00233,RC00535,RC02567,RC02694 ko00000,ko00001,ko01000 - - - LigA,LigB k59_1150972_2 627192.SLG_16870 1.42e-22 99.8 COG2207@1|root,COG2207@2|Bacteria,1MXDJ@1224|Proteobacteria,2TSY6@28211|Alphaproteobacteria,2K1BN@204457|Sphingomonadales 204457|Sphingomonadales K helix_turn_helix, arabinose operon control protein pobR - - ko:K18954 - - - - ko00000,ko03000 - - - AraC_binding,HTH_18 k59_247070_1 1144307.PMI04_01395 3.99e-30 124.0 COG0845@1|root,COG0845@2|Bacteria,1QMYR@1224|Proteobacteria,2U69D@28211|Alphaproteobacteria,2K0FV@204457|Sphingomonadales 204457|Sphingomonadales M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - - - - - - - - - - HlyD_D23 k59_1716211_1 1210884.HG799470_gene14491 2.69e-77 258.0 COG1198@1|root,COG1198@2|Bacteria,2IY1F@203682|Planctomycetes 203682|Planctomycetes L Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA priA - - ko:K04066 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,Helicase_C,ResIII k59_1377909_1 1121875.KB907549_gene1804 8.86e-39 135.0 COG0742@1|root,COG0742@2|Bacteria,4NM7J@976|Bacteroidetes,1I185@117743|Flavobacteriia 976|Bacteroidetes L Methyltransferase rsmD - 2.1.1.171 ko:K08316 - - R07234 RC00003 ko00000,ko01000,ko03009 - - - Cons_hypoth95 k59_1771949_1 316407.85676008 5.99e-57 182.0 COG3539@1|root,COG3539@2|Bacteria,1RIGE@1224|Proteobacteria,1S4HY@1236|Gammaproteobacteria 1236|Gammaproteobacteria NU Protein of unknown function (DUF1120) - GO:0005575,GO:0005623,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0030288,GO:0030313,GO:0031975,GO:0033554,GO:0042597,GO:0044464,GO:0050896,GO:0051716 - - - - - - - - - - DUF1120 k59_304638_1 1121912.AUHD01000006_gene1358 3.45e-29 117.0 COG2982@1|root,COG2982@2|Bacteria,4NEJQ@976|Bacteroidetes,1HXHN@117743|Flavobacteriia 976|Bacteroidetes M membrane - - - - - - - - - - - - AsmA,AsmA_2 k59_21671_1 247634.GPB2148_291 5.45e-19 85.5 COG3071@1|root,COG3071@2|Bacteria,1MU7A@1224|Proteobacteria,1RMRG@1236|Gammaproteobacteria 1236|Gammaproteobacteria H enzyme of heme biosynthesis hemY GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K02498 - - - - ko00000 - - - HemY_N,TPR_2 k59_21671_2 566466.NOR53_3718 1.59e-37 138.0 COG2959@1|root,COG2959@2|Bacteria,1MY3A@1224|Proteobacteria,1RNJY@1236|Gammaproteobacteria,1J8ZX@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H HemX, putative uroporphyrinogen-III C-methyltransferase hemX - 2.1.1.107,4.2.1.75 ko:K02496,ko:K13543 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R03165,R03194 RC00003,RC00871,RC01861 ko00000,ko00001,ko00002,ko01000 - - iAF1260.b3803,iBWG_1329.BWG_3482,iECDH1ME8569_1439.ECDH1ME8569_3682,iECUMN_1333.ECUMN_4327,iECs_1301.ECs4733,iEcDH1_1363.EcDH1_4176,iJO1366.b3803,iJR904.b3803,iPC815.YPO3851,iUMN146_1321.UM146_19140,iY75_1357.Y75_RS18060,iZ_1308.Z5317 HemX k59_22863_1 436308.Nmar_1516 2.3e-113 340.0 COG2304@1|root,arCOG02900@2157|Archaea,41SDY@651137|Thaumarchaeota 651137|Thaumarchaeota S von Willebrand factor (vWF) type A domain - - - - - - - - - - - - - k59_1433825_1 1458427.BAWN01000015_gene993 1.21e-99 302.0 2DBKD@1|root,2Z9SP@2|Bacteria,1PCCH@1224|Proteobacteria,2W3DS@28216|Betaproteobacteria 28216|Betaproteobacteria S Domain of unknown function (DUF4263) - - - - - - - - - - - - DUF4263 k59_700562_1 1248916.ANFY01000010_gene425 1.01e-114 352.0 COG0138@1|root,COG0138@2|Bacteria,1MUDQ@1224|Proteobacteria,2TRMY@28211|Alphaproteobacteria,2K0R5@204457|Sphingomonadales 204457|Sphingomonadales F Bifunctional purine biosynthesis protein PurH purH - 2.1.2.3,3.5.4.10 ko:K00602 ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523 M00048 R01127,R04560 RC00026,RC00263,RC00456 ko00000,ko00001,ko00002,ko01000,ko04147 - - - AICARFT_IMPCHas,MGS k59_417889_1 857087.Metme_2492 2.27e-55 186.0 COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,1RMAQ@1236|Gammaproteobacteria,1XG8U@135618|Methylococcales 135618|Methylococcales L Transposase - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_1209009_1 1096930.L284_04235 4.72e-90 278.0 COG0438@1|root,COG0438@2|Bacteria,1RBPW@1224|Proteobacteria,2U6IH@28211|Alphaproteobacteria,2K4BB@204457|Sphingomonadales 204457|Sphingomonadales M Glycosyltransferase Family 4 - - - - - - - - - - - - Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1 k59_305847_1 882083.SacmaDRAFT_4868 3.36e-14 77.4 COG2423@1|root,COG2423@2|Bacteria,2H4D8@201174|Actinobacteria 201174|Actinobacteria E ornithine cyclodeaminase ocd - 1.5.1.51,4.3.1.12 ko:K01750,ko:K21721 ko00330,ko01110,ko01130,ko01230,map00330,map01110,map01130,map01230 - R00671 RC00354 ko00000,ko00001,ko01000 - - - OCD_Mu_crystall k59_1152167_1 338963.Pcar_2581 1.8e-89 274.0 COG0536@1|root,COG0536@2|Bacteria,1MUGZ@1224|Proteobacteria,42M40@68525|delta/epsilon subdivisions,2WIM4@28221|Deltaproteobacteria,43S7S@69541|Desulfuromonadales 28221|Deltaproteobacteria S GTP1/OBG obg - - ko:K03979 - - - - ko00000,ko01000,ko03009 - - - GTP1_OBG,MMR_HSR1 k59_1152167_2 381764.Fnod_0436 3.45e-05 43.5 COG0211@1|root,COG0211@2|Bacteria,2GDCN@200918|Thermotogae 200918|Thermotogae J ribosomal protein L27 rpmA - - ko:K02899 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L27 k59_871008_1 795666.MW7_1975 2.11e-68 227.0 COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,2VH0Y@28216|Betaproteobacteria,1JZX3@119060|Burkholderiaceae 28216|Betaproteobacteria I 3-hydroxyacyl-coa dehydrogenase fadB - 1.1.1.35 ko:K07516 ko00071,ko00362,ko00650,ko01100,ko01120,ko01200,ko01212,map00071,map00362,map00650,map01100,map01120,map01200,map01212 M00087 R01975,R04737,R04739,R04741,R04743,R04745,R04748,R05305 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000 - - - 3HCDH,3HCDH_N,ECH_1 k59_1264167_1 1229909.NSED_02310 3.66e-117 348.0 COG0475@1|root,arCOG01955@2157|Archaea,41SG1@651137|Thaumarchaeota 651137|Thaumarchaeota P Sodium hydrogen exchanger - - - ko:K03455 - - - - ko00000 2.A.37 - - Na_H_Exchanger k59_22879_2 436308.Nmar_0268 8.5e-158 446.0 COG0483@1|root,arCOG01349@2157|Archaea,41SIF@651137|Thaumarchaeota 651137|Thaumarchaeota G Inositol monophosphatase - - 3.1.3.25 ko:K01092 ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070 M00131 R01185,R01186,R01187 RC00078 ko00000,ko00001,ko00002,ko01000 - - - Inositol_P k59_22879_3 1229909.NSED_01600 1.49e-06 56.6 arCOG08778@1|root,arCOG08778@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_1379122_1 45130.XP_007696461.1 6.33e-09 63.2 COG0644@1|root,2QW6Y@2759|Eukaryota,39W49@33154|Opisthokonta,3NXM9@4751|Fungi,3QPMV@4890|Ascomycota 4751|Fungi C monooxygenase activity - - - - - - - - - - - - Trp_halogenase k59_1604717_2 85643.Tmz1t_1331 5.56e-42 147.0 COG1131@1|root,COG1131@2|Bacteria,1MUW7@1224|Proteobacteria,2VM20@28216|Betaproteobacteria,2KYH2@206389|Rhodocyclales 206389|Rhodocyclales V AAA domain, putative AbiEii toxin, Type IV TA system - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_925759_1 272626.lin0273 6.22e-15 78.2 COG0566@1|root,COG0566@2|Bacteria,1TP9G@1239|Firmicutes,4HBBI@91061|Bacilli,26J72@186820|Listeriaceae 91061|Bacilli H Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family trmH GO:0000154,GO:0000451,GO:0000453,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070039,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.185 ko:K03218 - - - - ko00000,ko01000,ko03009 - - - SpoU_methylase,SpoU_sub_bind k59_587387_1 1122135.KB893135_gene770 1.05e-83 276.0 COG0642@1|root,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria 1224|Proteobacteria T Histidine kinase - - 2.7.13.3 ko:K20974 ko02020,ko02025,map02020,map02025 M00820 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - CHASE,HATPase_c,HisKA,Hpt,PAS_3,Response_reg k59_587387_2 1116369.KB890024_gene838 3.77e-05 45.1 COG1281@1|root,COG1281@2|Bacteria,1MUMU@1224|Proteobacteria,2TTUR@28211|Alphaproteobacteria,43IXI@69277|Phyllobacteriaceae 28211|Alphaproteobacteria O Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress hslO - - ko:K04083 - - - - ko00000,ko03110 - - - HSP33 k59_248245_1 247634.GPB2148_1878 9.41e-111 326.0 COG1159@1|root,COG1159@2|Bacteria,1MUKT@1224|Proteobacteria,1RN3A@1236|Gammaproteobacteria,1J4EI@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism era GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009898,GO:0009987,GO:0016020,GO:0016310,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019538,GO:0019843,GO:0019897,GO:0019898,GO:0022613,GO:0031234,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0036211,GO:0042254,GO:0042274,GO:0043021,GO:0043024,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0044877,GO:0046777,GO:0070181,GO:0071704,GO:0071840,GO:0071944,GO:0097159,GO:0097367,GO:0098552,GO:0098562,GO:1901265,GO:1901363,GO:1901564 - ko:K03595 - - - - ko00000,ko03009,ko03029 - - - KH_2,MMR_HSR1 k59_248245_2 1121937.AUHJ01000001_gene592 1.45e-21 90.5 COG0571@1|root,COG0571@2|Bacteria,1MUQ6@1224|Proteobacteria,1RN0C@1236|Gammaproteobacteria,466PY@72275|Alteromonadaceae 1236|Gammaproteobacteria J Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism rnc GO:0000287,GO:0003674,GO:0003676,GO:0003723,GO:0003725,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004525,GO:0004540,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006397,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016072,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019899,GO:0022613,GO:0032296,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043167,GO:0043169,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:1901360,GO:1901363 3.1.26.3 ko:K03685 ko03008,ko05205,map03008,map05205 - - - ko00000,ko00001,ko01000,ko03009,ko03019,ko03036 - - - Ribonucleas_3_3,dsrm k59_756016_1 1229909.NSED_05840 9.7e-141 418.0 COG0145@1|root,arCOG01511@2157|Archaea,41SZ7@651137|Thaumarchaeota 651137|Thaumarchaeota E N-methylhydantoinase A acetone carboxylase, beta subunit - - - - - - - - - - - - Hydant_A_N,Hydantoinase_A k59_925762_1 1219045.BV98_003466 1.14e-71 247.0 COG0587@1|root,COG0587@2|Bacteria,1MUE4@1224|Proteobacteria,2TRUB@28211|Alphaproteobacteria,2JZWI@204457|Sphingomonadales 204457|Sphingomonadales L DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase - - 2.7.7.7 ko:K14162 - - - - ko00000,ko01000,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP k59_981293_1 997346.HMPREF9374_0709 1.21e-71 229.0 COG0743@1|root,COG0743@2|Bacteria,1TP1C@1239|Firmicutes,4HBAV@91061|Bacilli,27B62@186824|Thermoactinomycetaceae 91061|Bacilli I 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal dxr - 1.1.1.267 ko:K00099 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05688 RC01452 ko00000,ko00001,ko00002,ko01000 - - - DXPR_C,DXP_redisom_C,DXP_reductoisom k59_1152200_1 588581.Cpap_2587 6.12e-41 148.0 COG0436@1|root,COG0436@2|Bacteria,1TQP0@1239|Firmicutes,2488K@186801|Clostridia,3WI7Q@541000|Ruminococcaceae 186801|Clostridia E PFAM Aminotransferase class I and II - - - - - - - - - - - - Aminotran_1_2 k59_1772728_1 1168065.DOK_18630 6.54e-46 167.0 COG2010@1|root,COG4993@1|root,COG2010@2|Bacteria,COG4993@2|Bacteria,1MUQX@1224|Proteobacteria,1RN5D@1236|Gammaproteobacteria,1J8FD@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C PQQ-like domain - - 1.1.2.8,1.1.9.1 ko:K00114,ko:K17760 ko00010,ko00625,ko01100,ko01110,ko01120,ko01130,map00010,map00625,map01100,map01110,map01120,map01130 - R05062,R05198,R05285 RC00087,RC00088,RC01039 ko00000,ko00001,ko01000 - - - Cytochrome_CBB3,PQQ,PQQ_2 k59_756020_1 1122137.AQXF01000002_gene149 3.36e-17 80.5 COG0303@1|root,COG0303@2|Bacteria,1MVD5@1224|Proteobacteria,2TQRI@28211|Alphaproteobacteria 28211|Alphaproteobacteria H COG0303 Molybdopterin biosynthesis enzyme moeA - 2.10.1.1 ko:K03750 ko00790,ko01100,map00790,map01100 - R09735 RC03462 ko00000,ko00001,ko01000 - - - MoCF_biosynth,MoeA_C,MoeA_N k59_756020_2 1336249.JADW01000001_gene2052 2.88e-64 201.0 COG0315@1|root,COG0315@2|Bacteria,1RCYZ@1224|Proteobacteria,2U747@28211|Alphaproteobacteria,4B71S@82115|Rhizobiaceae 28211|Alphaproteobacteria H Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP) moaC - 4.6.1.17 ko:K03637 ko00790,ko01100,ko04122,map00790,map01100,map04122 - R11372 RC03425 ko00000,ko00001,ko01000 - - - MoaC k59_592061_1 1123279.ATUS01000001_gene2525 4.82e-74 231.0 COG0266@1|root,COG0266@2|Bacteria,1MVM5@1224|Proteobacteria,1RP3J@1236|Gammaproteobacteria,1J5A0@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates fpg GO:0000702,GO:0000703,GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003824,GO:0003906,GO:0004518,GO:0004519,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006285,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008270,GO:0008534,GO:0009987,GO:0016787,GO:0016788,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034641,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901363 3.2.2.23,4.2.99.18 ko:K10563 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - Fapy_DNA_glyco,H2TH,zf-FPG_IleRS k59_875767_1 1122137.AQXF01000001_gene2883 1.14e-84 261.0 COG1463@1|root,COG1463@2|Bacteria,1MU4B@1224|Proteobacteria,2U1JN@28211|Alphaproteobacteria 28211|Alphaproteobacteria Q ABC-type transport system involved in resistance to organic solvents periplasmic component - - - ko:K02067,ko:K06192 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - MlaD k59_1775591_1 1229909.NSED_08675 1.08e-60 188.0 COG1308@1|root,arCOG04061@2157|Archaea,41SNN@651137|Thaumarchaeota 651137|Thaumarchaeota K Contacts the emerging nascent chain on the ribosome nac - - ko:K03626 - - - - ko00000 - - - NAC k59_367480_1 631454.N177_0269 1.41e-36 139.0 COG2309@1|root,COG2309@2|Bacteria,1MW2Y@1224|Proteobacteria,2TSGB@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Leucyl aminopeptidase (Aminopeptidase T) ampS - - ko:K19689 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M29 k59_1609646_1 1229909.NSED_05135 2.85e-136 400.0 COG0504@1|root,arCOG00063@2157|Archaea,41S7G@651137|Thaumarchaeota 651137|Thaumarchaeota F Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates pyrG - 6.3.4.2 ko:K01937 ko00240,ko01100,map00240,map01100 M00052 R00571,R00573 RC00010,RC00074 ko00000,ko00001,ko00002,ko01000 - - - CTP_synth_N,GATase k59_646580_1 1215114.BBIU01000002_gene62 3.7e-23 104.0 COG1629@1|root,COG4771@2|Bacteria,1MWKN@1224|Proteobacteria,1RZM0@1236|Gammaproteobacteria 1236|Gammaproteobacteria P Receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_85031_1 1121937.AUHJ01000001_gene675 4.39e-122 357.0 COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,1SXEW@1236|Gammaproteobacteria,46ADD@72275|Alteromonadaceae 1236|Gammaproteobacteria I Acyl-CoA dehydrogenase, C-terminal domain - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_27951_1 1498011.A0A096XUX6_9CAUD 1.47e-66 225.0 4QCZC@10239|Viruses,4QRH3@28883|Caudovirales 28883|Caudovirales S Bacterial DNA polymerase III alpha subunit - - - - - - - - - - - - - k59_646587_1 1229909.NSED_01125 4.29e-169 492.0 COG1204@1|root,arCOG00553@2157|Archaea,41SAK@651137|Thaumarchaeota 651137|Thaumarchaeota L DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks hel308 - - ko:K03726 - - - - ko00000,ko01000 - - - DEAD,HHH_5,Helicase_C k59_195190_1 981085.XP_010099759.1 1.94e-05 53.5 COG0517@1|root,2QVK2@2759|Eukaryota,37N4N@33090|Viridiplantae,3G8UD@35493|Streptophyta,4JEMT@91835|fabids 35493|Streptophyta S CBS domain-containing protein - - - - - - - - - - - - CBS,PB1 k59_367495_1 452637.Oter_1387 4.36e-96 296.0 COG4146@1|root,COG4146@2|Bacteria 2|Bacteria S symporter activity - - - ko:K03307 - - - - ko00000 2.A.21 - - SSF k59_815851_1 546274.EIKCOROL_01209 1.11e-47 160.0 COG0500@1|root,COG2226@2|Bacteria,1PWNI@1224|Proteobacteria,2WC6R@28216|Betaproteobacteria,2KSH4@206351|Neisseriales 206351|Neisseriales Q Nodulation protein S (NodS) - - - - - - - - - - - - - k59_1383833_1 326427.Cagg_1684 2.45e-22 95.1 COG1668@1|root,COG1668@2|Bacteria,2G9RA@200795|Chloroflexi 200795|Chloroflexi CP ABC-2 family transporter protein - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_2 k59_1383833_2 251229.Chro_4060 0.000353 43.9 COG1131@1|root,COG1131@2|Bacteria,1G11U@1117|Cyanobacteria,3VI2H@52604|Pleurocapsales 1117|Cyanobacteria V ABC-type multidrug transport system ATPase component - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_1213721_1 247634.GPB2148_1491 1.41e-80 252.0 COG1028@1|root,COG1028@2|Bacteria,1REA0@1224|Proteobacteria,1SMHH@1236|Gammaproteobacteria 1236|Gammaproteobacteria IQ COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - - - - - - - - - - - adh_short k59_85053_1 1255043.TVNIR_1115 1.01e-113 347.0 COG1523@1|root,COG1523@2|Bacteria,1MU19@1224|Proteobacteria,1RP6F@1236|Gammaproteobacteria,1WX62@135613|Chromatiales 135613|Chromatiales G Belongs to the glycosyl hydrolase 13 family - - 3.2.1.68 ko:K01214 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R09995,R11261 - ko00000,ko00001,ko00002,ko01000 - CBM48,GH13 - Alpha-amylase,CBM_48 k59_140487_1 158500.BV97_02295 2.69e-117 349.0 COG0138@1|root,COG0138@2|Bacteria,1MUDQ@1224|Proteobacteria,2TRMY@28211|Alphaproteobacteria,2K0R5@204457|Sphingomonadales 204457|Sphingomonadales F Bifunctional purine biosynthesis protein PurH purH - 2.1.2.3,3.5.4.10 ko:K00602 ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523 M00048 R01127,R04560 RC00026,RC00263,RC00456 ko00000,ko00001,ko00002,ko01000,ko04147 - - - AICARFT_IMPCHas,MGS k59_875798_1 629773.AORY01000001_gene2159 6.3e-62 213.0 COG4773@1|root,COG4773@2|Bacteria,1QTXJ@1224|Proteobacteria,2TWA4@28211|Alphaproteobacteria,2KEDC@204457|Sphingomonadales 204457|Sphingomonadales P TonB dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_705396_1 1000565.METUNv1_02487 5.81e-27 105.0 COG0284@1|root,COG0284@2|Bacteria,1MW2C@1224|Proteobacteria,2VJRD@28216|Betaproteobacteria 28216|Betaproteobacteria F Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) pyrF - 4.1.1.23 ko:K01591 ko00240,ko01100,map00240,map01100 M00051 R00965 RC00409 ko00000,ko00001,ko00002,ko01000 - - - OMPdecase k59_705396_2 740709.A10D4_05667 1.43e-62 201.0 COG0407@1|root,COG0407@2|Bacteria,1MUG1@1224|Proteobacteria,1RMDH@1236|Gammaproteobacteria,2QF55@267893|Idiomarinaceae 1236|Gammaproteobacteria H Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III hemE GO:0003674,GO:0003824,GO:0004853,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006536,GO:0006725,GO:0006778,GO:0006779,GO:0006780,GO:0006782,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009064,GO:0009987,GO:0016053,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019353,GO:0019438,GO:0019752,GO:0033013,GO:0033014,GO:0033526,GO:0034641,GO:0042168,GO:0042440,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046394,GO:0046483,GO:0046501,GO:0046502,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 4.1.1.37 ko:K01599 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R03197,R04972 RC00872 ko00000,ko00001,ko00002,ko01000 - - iPC815.YPO3734,iSBO_1134.SBO_4018 URO-D k59_646601_1 1144305.PMI02_02655 2.62e-55 185.0 COG1216@1|root,COG1216@2|Bacteria,1RDAK@1224|Proteobacteria,2UBKE@28211|Alphaproteobacteria,2K0ZU@204457|Sphingomonadales 204457|Sphingomonadales S Glycosyltransferase like family 2 - - - - - - - - - - - - Glycos_transf_2 k59_195209_1 1121022.ABENE_17135 1.36e-18 86.7 COG0530@1|root,COG0530@2|Bacteria,1MU3R@1224|Proteobacteria,2TST5@28211|Alphaproteobacteria,2KGMB@204458|Caulobacterales 204458|Caulobacterales P Sodium/calcium exchanger protein - - - ko:K07301 - - - - ko00000,ko02000 2.A.19.5 - - Na_Ca_ex k59_195209_2 1282876.BAOK01000001_gene1240 1.84e-61 197.0 COG1028@1|root,COG1028@2|Bacteria,1MUUV@1224|Proteobacteria,2TR0A@28211|Alphaproteobacteria,4BQ4Q@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria IQ Enoyl-(Acyl carrier protein) reductase ptr1 - - - - - - - - - - - adh_short,adh_short_C2 k59_1156067_1 1122137.AQXF01000002_gene477 1.54e-96 298.0 COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2TR2W@28211|Alphaproteobacteria 28211|Alphaproteobacteria IQ COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II - - - - - - - - - - - - AMP-binding,AMP-binding_C k59_1609691_1 1502852.FG94_02705 7.89e-30 122.0 COG0784@1|root,COG5002@1|root,COG0784@2|Bacteria,COG5002@2|Bacteria,1NC9X@1224|Proteobacteria,2WHDJ@28216|Betaproteobacteria,4794V@75682|Oxalobacteraceae 28216|Betaproteobacteria T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA,MEDS,PAS_4,PAS_9,Response_reg k59_929077_1 1122137.AQXF01000004_gene1547 3.75e-80 246.0 COG0796@1|root,COG0796@2|Bacteria,1NAI2@1224|Proteobacteria,2TSR7@28211|Alphaproteobacteria 28211|Alphaproteobacteria M Provides the (R)-glutamate required for cell wall biosynthesis murI - 5.1.1.3 ko:K01776 ko00471,ko01100,map00471,map01100 - R00260 RC00302 ko00000,ko00001,ko01000,ko01011 - - - Asp_Glu_race k59_1775617_1 56110.Oscil6304_3386 3.02e-29 122.0 COG0515@1|root,COG0642@1|root,COG2199@1|root,COG2203@1|root,COG3899@1|root,COG0515@2|Bacteria,COG2203@2|Bacteria,COG2205@2|Bacteria,COG3706@2|Bacteria,COG3899@2|Bacteria,1GBKM@1117|Cyanobacteria,1H7D9@1150|Oscillatoriales 2|Bacteria KLT Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase hstK - - - - - - - - - - - AAA_16,GAF,GAF_2,GGDEF,Guanylate_cyc,HATPase_c,HisKA,PAS_9,Pkinase,Response_reg,SpoIIE k59_1383859_1 1380600.AUYN01000012_gene3006 2.96e-56 181.0 2E5XB@1|root,32TRA@2|Bacteria,4NSFZ@976|Bacteroidetes,1I41W@117743|Flavobacteriia 976|Bacteroidetes S Domain of unknown function (DUF4251) - - - - - - - - - - - - DUF4251 k59_1156076_1 876044.IMCC3088_2538 4.28e-104 319.0 COG3653@1|root,COG3653@2|Bacteria,1MWWY@1224|Proteobacteria,1RYI9@1236|Gammaproteobacteria 1236|Gammaproteobacteria Q COG3653 N-acyl-D-aspartate D-glutamate deacylase - - - - - - - - - - - - Amidohydro_3 k59_815873_1 1384056.N787_01205 7.13e-120 369.0 COG1048@1|root,COG1048@2|Bacteria,1MU9T@1224|Proteobacteria,1RN5I@1236|Gammaproteobacteria,1X3SP@135614|Xanthomonadales 135614|Xanthomonadales C Catalyzes the isomerization of citrate to isocitrate via cis-aconitate acnA - 4.2.1.3 ko:K01681 ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00173,M00740 R01324,R01325,R01900 RC00497,RC00498,RC00618 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase,Aconitase_C k59_815874_1 1232410.KI421425_gene1549 3.67e-100 320.0 COG4105@1|root,COG4105@2|Bacteria,1QVQ9@1224|Proteobacteria,43CT2@68525|delta/epsilon subdivisions,2X80K@28221|Deltaproteobacteria,43TUA@69541|Desulfuromonadales 28221|Deltaproteobacteria S Tetratricopeptide repeat - - - - - - - - - - - - TPR_16,TPR_6 k59_476990_2 981369.JQMJ01000003_gene7667 2.23e-07 51.6 COG2026@1|root,COG2026@2|Bacteria,2IN19@201174|Actinobacteria,2NMRA@228398|Streptacidiphilus 201174|Actinobacteria DJ ParE toxin of type II toxin-antitoxin system, parDE - - - ko:K06218 - - - - ko00000,ko02048 - - - ParE_toxin k59_1045558_1 926569.ANT_28310 8.53e-57 187.0 COG0167@1|root,COG0167@2|Bacteria,2G5T6@200795|Chloroflexi 200795|Chloroflexi F Catalyzes the conversion of dihydroorotate to orotate - - 1.3.98.1 ko:K00226 ko00240,ko01100,map00240,map01100 M00051 R01867 RC00051 ko00000,ko00001,ko00002,ko01000 - - - DHO_dh k59_1383875_1 1296416.JACB01000006_gene273 2.41e-72 229.0 2DBKE@1|root,2Z9SW@2|Bacteria,4NRWN@976|Bacteroidetes,1I012@117743|Flavobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - Asp_protease_2 k59_1213759_1 1331060.RLDS_23495 4.57e-124 361.0 COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,2TQTP@28211|Alphaproteobacteria,2K2SD@204457|Sphingomonadales 204457|Sphingomonadales L Transposase - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_759309_1 436308.Nmar_1320 1.15e-153 455.0 COG1205@1|root,arCOG00555@2157|Archaea,41SZS@651137|Thaumarchaeota 651137|Thaumarchaeota L DEAD DEAH box helicase - - - ko:K06877 - - - - ko00000 - - - DEAD,DUF1998,Helicase_C k59_28013_1 261292.Nit79A3_0953 4.36e-46 167.0 COG3039@1|root,COG3039@2|Bacteria,1R6NB@1224|Proteobacteria,2W14S@28216|Betaproteobacteria 28216|Betaproteobacteria L Transposase - - - - - - - - - - - - - k59_477003_1 1137799.GZ78_05235 5.41e-130 384.0 COG0306@1|root,COG0306@2|Bacteria,1MVXK@1224|Proteobacteria,1RP0Q@1236|Gammaproteobacteria,1XIG9@135619|Oceanospirillales 135619|Oceanospirillales P phosphate transporter - - - ko:K03306 - - - - ko00000 2.A.20 - - PHO4 k59_1099055_1 998674.ATTE01000001_gene3642 1.77e-23 100.0 COG0751@1|root,COG0751@2|Bacteria,1MV2F@1224|Proteobacteria,1RNR3@1236|Gammaproteobacteria,45ZWF@72273|Thiotrichales 72273|Thiotrichales J Glycyl-tRNA synthetase beta subunit glyS - 6.1.1.14 ko:K01879 ko00970,map00970 M00360 R03654 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DALR_1,tRNA_synt_2f k59_1099055_2 396588.Tgr7_3256 4.64e-52 173.0 COG0752@1|root,COG0752@2|Bacteria,1MVCJ@1224|Proteobacteria,1RMYI@1236|Gammaproteobacteria,1WWUE@135613|Chromatiales 135613|Chromatiales J glycyl-tRNA synthetase alpha subunit glyQ - 6.1.1.14 ko:K01878 ko00970,map00970 M00360 R03654 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_2e k59_1213777_1 1459636.NTE_02664 1.48e-23 105.0 COG1409@1|root,arCOG06534@1|root,arCOG07781@1|root,arCOG09729@1|root,arCOG06534@2157|Archaea,arCOG07781@2157|Archaea,arCOG09729@2157|Archaea,arCOG11020@2157|Archaea 2157|Archaea S cell adhesion involved in biofilm formation - - - - - - - - - - - - Big_1,CHB_HEX_C_1,He_PIG,PKD,Polysacc_deac_1 k59_1609732_1 391615.ABSJ01000016_gene1741 1.7e-121 360.0 COG0860@1|root,COG0860@2|Bacteria,1MUQK@1224|Proteobacteria,1RMP1@1236|Gammaproteobacteria 1236|Gammaproteobacteria M N-acetylmuramoyl-L-alanine amidase amiC GO:0000003,GO:0000910,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0007049,GO:0008150,GO:0008745,GO:0009987,GO:0016787,GO:0016810,GO:0016811,GO:0019954,GO:0022402,GO:0022414,GO:0030288,GO:0030313,GO:0031975,GO:0032505,GO:0042597,GO:0043093,GO:0044464,GO:0051301,GO:0061783 3.5.1.28 ko:K01448 ko01503,map01503 M00727 R04112 RC00064,RC00141 ko00000,ko00001,ko00002,ko01000,ko01011,ko03036 - - iPC815.YPO1023,iSDY_1059.SDY_3034,iYL1228.KPN_03225 AMIN,Amidase_3,LysM k59_1664653_1 479434.Sthe_0412 5.78e-16 71.6 COG4481@1|root,COG4481@2|Bacteria,2G9W8@200795|Chloroflexi,27YMV@189775|Thermomicrobia 189775|Thermomicrobia S Bacterial protein of unknown function (DUF951) - - - - - - - - - - - - DUF951 k59_1664653_2 511051.CSE_14850 4.12e-21 94.4 COG0312@1|root,COG0312@2|Bacteria 2|Bacteria S metallopeptidase activity tldE2 - - - - - - - - - - - PmbA_TldD k59_195256_1 436308.Nmar_0099 2.8e-87 276.0 COG2511@1|root,arCOG01719@2157|Archaea,41S8Q@651137|Thaumarchaeota 651137|Thaumarchaeota J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate gatE - 6.3.5.7 ko:K03330 ko00970,ko01100,map00970,map01100 - R03905 RC00010 ko00000,ko00001,ko01000 - - - GAD,GatB_N,GatB_Yqey k59_1099067_1 316407.85675804 1.5e-151 429.0 COG0437@1|root,COG0437@2|Bacteria,1MU1B@1224|Proteobacteria,1RPF5@1236|Gammaproteobacteria,3XNNR@561|Escherichia 1236|Gammaproteobacteria C Participates in the periplasmic electron-transferring activity of hydrogenase 2 during its catalytic turnover hybA GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0005975,GO:0006066,GO:0006071,GO:0006091,GO:0006113,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016052,GO:0019400,GO:0019405,GO:0019563,GO:0019588,GO:0019662,GO:0019751,GO:0031224,GO:0031226,GO:0042597,GO:0044237,GO:0044238,GO:0044248,GO:0044262,GO:0044275,GO:0044281,GO:0044282,GO:0044425,GO:0044459,GO:0044464,GO:0046164,GO:0046174,GO:0055114,GO:0071704,GO:0071944,GO:1901575,GO:1901615,GO:1901616 - - - - - - - - - - Fer4_11,Fer4_7 k59_1553928_1 322710.Avin_51000 1.08e-69 226.0 COG3604@1|root,COG3604@2|Bacteria,1QTT3@1224|Proteobacteria,1T1G7@1236|Gammaproteobacteria 1236|Gammaproteobacteria KT transcriptional regulator nifA - - ko:K02584 ko02020,map02020 - - - ko00000,ko00001,ko03000 - - - GAF,GAF_2,HTH_8,Sigma54_activat k59_1268083_1 1453501.JELR01000002_gene163 7.19e-25 105.0 COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,1RMWA@1236|Gammaproteobacteria,464SM@72275|Alteromonadaceae 1236|Gammaproteobacteria JKL DEAD-box RNA helicase involved in RNA degradation. Has RNA-dependent ATPase activity and unwinds double-stranded RNA rhlB GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009056,GO:0009057,GO:0009987,GO:0010501,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019439,GO:0019904,GO:0034641,GO:0034655,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0070035,GO:0071704,GO:0090304,GO:0097718,GO:0140098,GO:1901360,GO:1901361,GO:1901575 3.6.4.13 ko:K03732 ko03018,map03018 M00394 - - ko00000,ko00001,ko00002,ko01000,ko03019 - - - DEAD,Helicase_C,RhlB k59_85140_1 448385.sce0791 2.3e-39 144.0 COG1944@1|root,COG1944@2|Bacteria,1N5NV@1224|Proteobacteria,42VNR@68525|delta/epsilon subdivisions,2WSCG@28221|Deltaproteobacteria,2YXER@29|Myxococcales 28221|Deltaproteobacteria S YcaO cyclodehydratase, ATP-ad Mg2+-binding - - - ko:K09136 - - - - ko00000,ko03009 - - - YcaO k59_1268086_1 399795.CtesDRAFT_PD0496 5.47e-08 53.1 COG0773@1|root,COG0773@2|Bacteria,1MUC5@1224|Proteobacteria,2VIX5@28216|Betaproteobacteria,4A9UY@80864|Comamonadaceae 28216|Betaproteobacteria M Reutilizes the intact tripeptide L-alanyl-gamma-D- glutamyl-meso-diaminopimelate by linking it to UDP-N- acetylmuramate mpl - 6.3.2.45 ko:K02558 - - - - ko00000,ko01000 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_1776411_1 1121422.AUMW01000007_gene3150 3.94e-51 180.0 COG0544@1|root,COG0544@2|Bacteria,1TQQ8@1239|Firmicutes,248C3@186801|Clostridia,260PB@186807|Peptococcaceae 186801|Clostridia D Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase tig GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - ko:K03545 - - - - ko00000 - - - FKBP_C,Trigger_C,Trigger_N k59_422357_1 279714.FuraDRAFT_1434 1.02e-100 302.0 COG0226@1|root,COG0226@2|Bacteria,1MUAZ@1224|Proteobacteria,2VIJV@28216|Betaproteobacteria,2KPQ9@206351|Neisseriales 206351|Neisseriales P Part of the ABC transporter complex PstSACB involved in phosphate import pstS - - ko:K02040 ko02010,ko02020,ko05152,map02010,map02020,map05152 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - PBP_like_2 k59_1438238_1 479434.Sthe_1649 2.39e-59 199.0 COG0064@1|root,COG0064@2|Bacteria,2G62Q@200795|Chloroflexi,27Y3E@189775|Thermomicrobia 189775|Thermomicrobia J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) gatB - 6.3.5.6,6.3.5.7 ko:K02434 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - GatB_N,GatB_Yqey k59_1498606_1 700508.D174_04800 5.72e-13 71.2 COG0665@1|root,COG0665@2|Bacteria,2GJVR@201174|Actinobacteria,232EH@1762|Mycobacteriaceae 201174|Actinobacteria E Glycine oxidase thiO - 1.4.3.19 ko:K03153 ko00730,ko01100,map00730,map01100 - R07463 RC01788 ko00000,ko00001,ko01000 - - - DAO k59_1610933_1 1004785.AMBLS11_06410 4.91e-34 131.0 COG5265@1|root,COG5265@2|Bacteria,1NSKS@1224|Proteobacteria,1T1W9@1236|Gammaproteobacteria,463YF@72275|Alteromonadaceae 1236|Gammaproteobacteria V COG5265 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components atmA - - ko:K06147 - - - - ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran k59_1438239_1 316275.VSAL_II0247 6.97e-09 57.4 COG2223@1|root,COG2223@2|Bacteria,1MU27@1224|Proteobacteria,1RP5H@1236|Gammaproteobacteria,1XUSE@135623|Vibrionales 135623|Vibrionales P Major Facilitator Superfamily - - - ko:K02575 ko00910,map00910 M00615 - - ko00000,ko00001,ko00002,ko02000 2.A.1.8 - - MFS_1 k59_141493_1 189753.AXAS01000016_gene1505 1.93e-07 62.0 COG0457@1|root,COG3710@1|root,COG5616@1|root,COG0457@2|Bacteria,COG3710@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2UPWB@28211|Alphaproteobacteria,3K3C4@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria K Transcriptional regulatory protein, C terminal - - - - - - - - - - - - TPR_8,Trans_reg_C k59_985747_1 316407.85676837 1.61e-107 317.0 COG1940@1|root,COG1940@2|Bacteria,1R5PJ@1224|Proteobacteria,1RZZI@1236|Gammaproteobacteria,3XQUS@561|Escherichia 1236|Gammaproteobacteria F Catalyzes the phosphorylation of D-allose to D-allose 6- phosphate alsK GO:0003674,GO:0003824,GO:0004340,GO:0004396,GO:0005975,GO:0005996,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008787,GO:0009056,GO:0009987,GO:0016052,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019200,GO:0019313,GO:0019314,GO:0019316,GO:0019318,GO:0019320,GO:0019637,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0046365,GO:0046367,GO:0046835,GO:0051156,GO:0071704,GO:1901135,GO:1901575 2.7.1.55 ko:K00881 ko00051,ko01120,map00051,map01120 - R03576 RC00002,RC00017 ko00000,ko00001,ko01000 - - iECSF_1327.ECSF_3965,iLF82_1304.LF82_0079,iNRG857_1313.NRG857_20490,iY75_1357.Y75_RS21265 ROK k59_985747_2 199310.c5091 1.59e-12 65.1 COG0036@1|root,COG0036@2|Bacteria,1MX3K@1224|Proteobacteria,1RSAB@1236|Gammaproteobacteria,3XQCQ@561|Escherichia 1236|Gammaproteobacteria G Catalyzes the reversible epimerization of D-allulose 6- phosphate to D-fructose 6-phosphate. Can also catalyze with lower efficiency the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate alsE GO:0003674,GO:0003824,GO:0004750,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009052,GO:0009056,GO:0009117,GO:0009987,GO:0016052,GO:0016853,GO:0016854,GO:0016857,GO:0019313,GO:0019314,GO:0019316,GO:0019318,GO:0019320,GO:0019321,GO:0019323,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0034700,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046367,GO:0046483,GO:0046496,GO:0046872,GO:0051156,GO:0051186,GO:0055086,GO:0071704,GO:0072524,GO:1901135,GO:1901360,GO:1901564,GO:1901575 - ko:K17195 ko00051,ko01120,map00051,map01120 - R09031 RC03111 ko00000,ko00001,ko01000 - - iEcSMS35_1347.EcSMS35_4551 Ribul_P_3_epim k59_477949_1 234267.Acid_2294 2.27e-40 158.0 COG0745@1|root,COG2202@1|root,COG4191@1|root,COG0745@2|Bacteria,COG2202@2|Bacteria,COG4191@2|Bacteria 2|Bacteria T Histidine kinase - - - - - - - - - - - - GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg,SBP_bac_3 k59_1723611_1 498211.CJA_3015 3.4e-104 316.0 COG2160@1|root,COG2160@2|Bacteria,1MW0J@1224|Proteobacteria,1RQEF@1236|Gammaproteobacteria,1FH1S@10|Cellvibrio 1236|Gammaproteobacteria G Catalyzes the conversion of L-arabinose to L-ribulose araA GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008733,GO:0009056,GO:0009058,GO:0009987,GO:0016052,GO:0016853,GO:0016860,GO:0016861,GO:0019321,GO:0019323,GO:0019566,GO:0019568,GO:0019569,GO:0019572,GO:0019637,GO:0044237,GO:0044238,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046373,GO:0051167,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901159,GO:1901575,GO:1901576 5.3.1.4 ko:K01804 ko00040,ko01100,map00040,map01100 - R01761 RC00516 ko00000,ko00001,ko01000 - - iAPECO1_1312.APECO1_1922,iB21_1397.B21_00063,iBWG_1329.BWG_0058,iE2348C_1286.E2348C_0063,iECBD_1354.ECBD_3555,iECD_1391.ECD_00064,iECED1_1282.ECED1_0061,iECIAI1_1343.ECIAI1_0062,iECNA114_1301.ECNA114_0050,iECO103_1326.ECO103_0063,iECO26_1355.ECO26_0064,iECOK1_1307.ECOK1_0061,iECP_1309.ECP_0063,iECS88_1305.ECS88_0065,iECSE_1348.ECSE_0062,iECW_1372.ECW_m0060,iEKO11_1354.EKO11_3852,iEcE24377_1341.EcE24377A_0064,iEcHS_1320.EcHS_A0066,iEcSMS35_1347.EcSMS35_0064,iEcolC_1368.EcolC_3595,iLF82_1304.LF82_0105,iNRG857_1313.NRG857_00320,iSBO_1134.SBO_0049,iSSON_1240.SSON_0068,iUMN146_1321.UM146_23095,iUTI89_1310.UTI89_C0067,iWFL_1372.ECW_m0060 Arabinose_Iso_C,Arabinose_Isome k59_1385202_1 1122137.AQXF01000002_gene304 2.18e-28 107.0 COG0593@1|root,COG0593@2|Bacteria,1N4PG@1224|Proteobacteria,2U96K@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Belongs to the DnaA family hda - - - - - - - - - - - Bac_DnaA k59_1385202_2 1122137.AQXF01000002_gene305 2.51e-69 223.0 COG0628@1|root,COG0628@2|Bacteria,1MW0B@1224|Proteobacteria,2TRD3@28211|Alphaproteobacteria 28211|Alphaproteobacteria S permease perM - - ko:K03548 - - - - ko00000,ko02000 2.A.86.1 - - AI-2E_transport k59_877147_1 1123401.JHYQ01000019_gene1496 7.55e-85 268.0 COG0445@1|root,COG0445@2|Bacteria,1MU6F@1224|Proteobacteria,1RMM1@1236|Gammaproteobacteria,4604K@72273|Thiotrichales 72273|Thiotrichales D NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 gidA - - ko:K03495 - - R08701 RC00053,RC00209,RC00870 ko00000,ko03016,ko03036 - - - GIDA,GIDA_assoc k59_1215024_1 290317.Cpha266_2522 1.26e-14 77.8 COG0668@1|root,COG0668@2|Bacteria 2|Bacteria M transmembrane transport - - - ko:K03442,ko:K22044 - - - - ko00000,ko02000 1.A.23.2,1.A.23.3 - - LysM,MS_channel,Mu-transpos_C,rve k59_311976_1 394221.Mmar10_1457 1.85e-43 164.0 COG5616@1|root,COG5616@2|Bacteria,1NSKC@1224|Proteobacteria,2TWZ1@28211|Alphaproteobacteria,44159@69657|Hyphomonadaceae 28211|Alphaproteobacteria K cAMP biosynthetic process - - - - - - - - - - - - Guanylate_cyc,Trans_reg_C k59_1046812_1 765912.Thimo_2518 4.44e-44 151.0 COG2834@1|root,COG2834@2|Bacteria,1MXW0@1224|Proteobacteria,1RS0K@1236|Gammaproteobacteria,1WY05@135613|Chromatiales 135613|Chromatiales M Outer membrane lipoprotein-sorting protein - - - - - - - - - - - - LolA_like k59_1046812_2 765912.Thimo_2519 1.71e-25 103.0 COG4591@1|root,COG4591@2|Bacteria,1R4Q2@1224|Proteobacteria,1RQW0@1236|Gammaproteobacteria,1X1HR@135613|Chromatiales 135613|Chromatiales M ABC-type transport system, involved in lipoprotein release, permease component - - - - - - - - - - - - FtsX,MacB_PCD k59_1555316_1 384765.SIAM614_05426 6.49e-94 300.0 COG0247@1|root,COG0277@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,2TSN5@28211|Alphaproteobacteria 28211|Alphaproteobacteria C FAD linked oxidase domain protein MA20_43170 - - - - - - - - - - - CCG,FAD-oxidase_C,FAD_binding_4,Fer4_8 k59_311978_2 1123488.ATUF01000002_gene352 1.72e-24 101.0 COG0009@1|root,COG0009@2|Bacteria,2GK2X@201174|Actinobacteria,4D3PC@85005|Actinomycetales 201174|Actinobacteria J Belongs to the SUA5 family - - 2.7.7.87 ko:K07566 - - R10463 RC00745 ko00000,ko01000,ko03009,ko03016 - - - Sua5_yciO_yrdC k59_1610947_1 1121939.L861_22545 1.04e-165 506.0 COG1201@1|root,COG1201@2|Bacteria,1MUSW@1224|Proteobacteria,1RSNV@1236|Gammaproteobacteria,1XNJ7@135619|Oceanospirillales 135619|Oceanospirillales L DEAD/H associated - - - ko:K03724 - - - - ko00000,ko01000,ko03400 - - - DEAD,DEAD_assoc,Helicase_C k59_985761_1 1068980.ARVW01000001_gene1509 1.21e-74 249.0 28IUR@1|root,2Z8TE@2|Bacteria,2I9P5@201174|Actinobacteria,4E2HC@85010|Pseudonocardiales 201174|Actinobacteria - - - - - - - - - - - - - - - k59_1215029_1 702113.PP1Y_AT30762 1.3e-97 300.0 COG0497@1|root,COG0497@2|Bacteria,1MUNP@1224|Proteobacteria,2TREW@28211|Alphaproteobacteria,2K043@204457|Sphingomonadales 204457|Sphingomonadales L May be involved in recombinational repair of damaged DNA recN - - ko:K03631 - - - - ko00000,ko03400 - - - SMC_N k59_86478_1 886293.Sinac_1559 9.35e-156 457.0 COG1132@1|root,COG1132@2|Bacteria,2IYCU@203682|Planctomycetes 2|Bacteria V ABC-type multidrug transport system ATPase and permease - - - ko:K06147 - - - - ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_tran k59_1555330_1 279238.Saro_2610 2.57e-39 144.0 COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2TQR1@28211|Alphaproteobacteria,2JZVD@204457|Sphingomonadales 204457|Sphingomonadales C belongs to the aldehyde dehydrogenase family - - 1.2.1.60,1.2.1.8 ko:K00130,ko:K00151 ko00260,ko00350,ko01100,ko01120,ko01220,map00260,map00350,map01100,map01120,map01220 M00533,M00555 R02565,R02566,R04418 RC00080,RC00254 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_1555330_2 279238.Saro_2609 7.45e-17 81.6 COG0174@1|root,COG0174@2|Bacteria,1MU6V@1224|Proteobacteria,2U0Z2@28211|Alphaproteobacteria,2KCZZ@204457|Sphingomonadales 204457|Sphingomonadales E Glutamine synthetase, catalytic domain - - 6.3.1.2 ko:K01915 ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 - R00253 RC00010,RC02798 ko00000,ko00001,ko01000,ko04147 - - - Gln-synt_C k59_1157323_2 1122137.AQXF01000004_gene1723 9.61e-83 260.0 COG1297@1|root,COG1297@2|Bacteria,1N7SK@1224|Proteobacteria,2TRCZ@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Oligopeptide transporter OPT - - - - - - - - - - - - OPT k59_1438274_1 331869.BAL199_16368 3.89e-24 99.0 COG3384@1|root,COG3384@2|Bacteria,1MXJZ@1224|Proteobacteria,2TRJT@28211|Alphaproteobacteria,4BS10@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria C Catalytic LigB subunit of aromatic ring-opening dioxygenase - - - ko:K15777 ko00965,map00965 - R08836 RC00387 ko00000,ko00001,ko01000 - - - LigB k59_1438274_2 998674.ATTE01000001_gene901 6.32e-49 160.0 COG2259@1|root,COG2259@2|Bacteria,1N06A@1224|Proteobacteria,1S92U@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Membrane - - - ko:K15977 - - - - ko00000 - - - DoxX k59_985773_1 1120960.ATXG01000003_gene2159 9.63e-34 126.0 COG1718@1|root,COG1718@2|Bacteria,2GM3J@201174|Actinobacteria,4FN3V@85023|Microbacteriaceae 201174|Actinobacteria DT RIO1 family - - 2.7.11.1 ko:K07178 ko03008,map03008 - - - ko00000,ko00001,ko01000,ko01001,ko03009 - - - RIO1 k59_533340_1 765420.OSCT_2101 2.35e-75 243.0 COG2303@1|root,COG2303@2|Bacteria,2G7EB@200795|Chloroflexi 200795|Chloroflexi E GMC oxidoreductase - - - - - - - - - - - - GMC_oxred_C,GMC_oxred_N k59_141536_1 675635.Psed_4248 8.84e-51 181.0 COG0654@1|root,COG1902@1|root,COG0654@2|Bacteria,COG1902@2|Bacteria,2GK8E@201174|Actinobacteria,4DXEE@85010|Pseudonocardiales 201174|Actinobacteria CH NADH:flavin oxidoreductase / NADH oxidase family - - 1.14.13.40 ko:K09461 ko00627,ko01120,map00627,map01120 - R03998,R03999 RC00244 ko00000,ko00001,ko01000 - - - FAD_binding_3,NAD_binding_8,Oxidored_FMN k59_653736_1 94122.Shewana3_0462 3.24e-34 130.0 COG2321@1|root,COG2321@2|Bacteria,1MU4U@1224|Proteobacteria,1RMF8@1236|Gammaproteobacteria,2QBKJ@267890|Shewanellaceae 1236|Gammaproteobacteria S Putative neutral zinc metallopeptidase - - - ko:K07054 - - - - ko00000 - - - Zn_peptidase k59_1221340_1 1120971.AUCA01000027_gene726 3.26e-70 221.0 COG3666@1|root,COG3666@2|Bacteria,1TQQ9@1239|Firmicutes,4HQUX@91061|Bacilli 91061|Bacilli L Transposase domain (DUF772) - - - - - - - - - - - - DUF772 k59_1053369_1 1123037.AUDE01000017_gene2549 6.81e-86 261.0 COG0136@1|root,COG0136@2|Bacteria,4NE4V@976|Bacteroidetes,1HYS3@117743|Flavobacteriia 976|Bacteroidetes E Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate asd - 1.2.1.11 ko:K00133 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00017,M00018,M00033,M00525,M00526,M00527 R02291 RC00684 ko00000,ko00001,ko00002,ko01000 - - - Semialdhyde_dh,Semialdhyde_dhC k59_320395_1 765913.ThidrDRAFT_4025 3.4e-59 197.0 COG1009@1|root,COG1009@2|Bacteria,1MW2M@1224|Proteobacteria,1RNKN@1236|Gammaproteobacteria,1WWIH@135613|Chromatiales 135613|Chromatiales CP PFAM NADH Ubiquinone plastoquinone - - - ko:K05568 - - - - ko00000,ko02000 2.A.63.1,2.A.63.2 - - Proton_antipo_M,Proton_antipo_N k59_538708_1 1096930.L284_10280 7.51e-104 323.0 COG0187@1|root,COG0187@2|Bacteria,1MVKT@1224|Proteobacteria,2TRBK@28211|Alphaproteobacteria,2K0E4@204457|Sphingomonadales 204457|Sphingomonadales L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrB - 5.99.1.3 ko:K02470 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim k59_1444488_1 1117319.PSPO_05521 3.91e-19 92.0 COG2327@1|root,COG2327@2|Bacteria,1RBZ1@1224|Proteobacteria,1S2CC@1236|Gammaproteobacteria,2Q4AZ@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria S Polysaccharide pyruvyl transferase - - - ko:K16710 - - - - ko00000 - - - PS_pyruv_trans k59_320398_1 428125.CLOLEP_03914 2.7e-11 70.1 COG1215@1|root,COG1216@1|root,COG2227@1|root,COG1215@2|Bacteria,COG1216@2|Bacteria,COG2227@2|Bacteria,1TQU0@1239|Firmicutes,248HP@186801|Clostridia,3WHZS@541000|Ruminococcaceae 186801|Clostridia M Glycosyltransferase, group 2 family protein - - - ko:K20444 - - - - ko00000,ko01000,ko01005,ko02000 4.D.1.3 GT2,GT4 - Glycos_transf_2 k59_714813_1 702113.PP1Y_AT1737 5.68e-99 301.0 COG0348@1|root,COG0348@2|Bacteria,1MVFY@1224|Proteobacteria,2TRYB@28211|Alphaproteobacteria,2K0BY@204457|Sphingomonadales 204457|Sphingomonadales C Nitrogen fixation protein fixG ccoG - - - - - - - - - - - Fer4_18,Fer4_5,FixG_C k59_376887_1 1123242.JH636435_gene1695 1.07e-52 177.0 COG0714@1|root,COG0714@2|Bacteria,2IX1F@203682|Planctomycetes 203682|Planctomycetes S ATPase associated with - - - ko:K03924 - - - - ko00000,ko01000 - - - AAA_3 k59_93016_1 1123053.AUDG01000052_gene1905 2.49e-112 331.0 COG2801@1|root,COG2801@2|Bacteria,1MVXQ@1224|Proteobacteria,1RR4F@1236|Gammaproteobacteria,1WXZW@135613|Chromatiales 135613|Chromatiales L PFAM integrase - - - ko:K07497 - - - - ko00000 - - - HTH_21,rve,rve_2 k59_93016_2 1123053.AUDG01000052_gene1904 3.11e-31 114.0 COG2963@1|root,COG2963@2|Bacteria,1N1CG@1224|Proteobacteria,1SAIC@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Transposase - - - ko:K07483 - - - - ko00000 - - - HTH_Tnp_1 k59_1444496_1 266117.Rxyl_1986 9.21e-19 92.8 COG5282@1|root,COG5282@2|Bacteria,2GJ8E@201174|Actinobacteria,4CT3X@84995|Rubrobacteria 84995|Rubrobacteria S Zincin-like metallopeptidase - - - - - - - - - - - - Zincin_2 k59_1444496_2 1240349.ANGC01000008_gene1087 2.35e-36 129.0 COG1225@1|root,COG1225@2|Bacteria,2GKME@201174|Actinobacteria,4FUKE@85025|Nocardiaceae 201174|Actinobacteria O Redoxin ahpE GO:0003674,GO:0003824,GO:0004601,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0008150,GO:0008152,GO:0009605,GO:0009607,GO:0009636,GO:0009987,GO:0016209,GO:0016491,GO:0016684,GO:0020012,GO:0030682,GO:0042221,GO:0043207,GO:0044403,GO:0044413,GO:0044415,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051409,GO:0051701,GO:0051704,GO:0051707,GO:0051716,GO:0051805,GO:0051807,GO:0051832,GO:0051834,GO:0051920,GO:0052060,GO:0052173,GO:0052200,GO:0052376,GO:0052551,GO:0052564,GO:0052565,GO:0052572,GO:0055114,GO:0070887,GO:0075136,GO:0097237,GO:0098754,GO:0098869,GO:1990748 1.11.1.15 ko:K03386 ko04214,map04214 - - - ko00000,ko00001,ko01000,ko04147 - - - AhpC-TSA k59_714821_1 414684.RC1_0744 1.96e-17 86.3 COG2244@1|root,COG2244@2|Bacteria,1RDQG@1224|Proteobacteria,2U27A@28211|Alphaproteobacteria,2JVP9@204441|Rhodospirillales 204441|Rhodospirillales S PFAM polysaccharide biosynthesis protein - - - - - - - - - - - - Polysacc_synt,Polysacc_synt_3 k59_262121_1 1458357.BG58_23425 2.07e-34 134.0 COG3387@1|root,COG3387@2|Bacteria,1MV08@1224|Proteobacteria,2VHBN@28216|Betaproteobacteria,1K0YU@119060|Burkholderiaceae 28216|Betaproteobacteria G PFAM glycoside hydrolase 15-related - - - - - - - - - - - - Glyco_hydro_15 k59_824931_1 331869.BAL199_15543 2.5e-51 177.0 COG2816@1|root,COG2816@2|Bacteria,1QGCX@1224|Proteobacteria,2TVMG@28211|Alphaproteobacteria,4BQFR@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria L NADH pyrophosphatase-like rudimentary NUDIX domain nudC - 3.6.1.22 ko:K03426 ko00760,ko01100,ko04146,map00760,map01100,map04146 - R00103,R03004,R11104 RC00002 ko00000,ko00001,ko01000 - - - NUDIX,NUDIX-like,zf-NADH-PPase k59_320423_1 156889.Mmc1_1588 9.22e-55 176.0 COG3043@1|root,COG3043@2|Bacteria,1RHGD@1224|Proteobacteria,2U6Q2@28211|Alphaproteobacteria 28211|Alphaproteobacteria C Electron transfer subunit of the periplasmic nitrate reductase complex NapAB napB - - ko:K02568 ko00910,ko01120,map00910,map01120 M00529,M00530 R00798 RC02812 ko00000,ko00001,ko00002 - - - NapB k59_1221376_2 1122137.AQXF01000007_gene3519 8.91e-81 246.0 COG3751@1|root,COG3751@2|Bacteria,1N3MA@1224|Proteobacteria,2VGIM@28211|Alphaproteobacteria 28211|Alphaproteobacteria O 2OG-Fe(II) oxygenase superfamily - - - - - - - - - - - - 2OG-FeII_Oxy_4 k59_885319_1 1229909.NSED_02230 3.54e-07 53.5 arCOG08684@1|root,arCOG08684@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_1671482_1 550540.Fbal_2781 1.8e-70 238.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria 1236|Gammaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family bepG - - ko:K03296 - - - - ko00000 2.A.6.2 - - ACR_tran k59_320433_1 690850.Desaf_2953 1.46e-48 172.0 COG0373@1|root,COG0373@2|Bacteria,1MU41@1224|Proteobacteria,42MUG@68525|delta/epsilon subdivisions,2WISB@28221|Deltaproteobacteria,2M7UJ@213115|Desulfovibrionales 28221|Deltaproteobacteria H Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) hemA - 1.2.1.70 ko:K02492 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R04109 RC00055,RC00149 ko00000,ko00001,ko00002,ko01000 - - - GlutR_N,GlutR_dimer,Shikimate_DH k59_204529_1 1333507.AUTQ01000261_gene3825 3.68e-88 273.0 COG1282@1|root,COG1282@2|Bacteria,1MUP4@1224|Proteobacteria,1RMR4@1236|Gammaproteobacteria 1236|Gammaproteobacteria C The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane pntB - 1.6.1.2 ko:K00325 ko00760,ko01100,map00760,map01100 - R00112 RC00001 ko00000,ko00001,ko01000 - - - PNTB k59_1221384_1 224911.27353510 1.02e-55 187.0 COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,2TS6B@28211|Alphaproteobacteria,3JUYU@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria O Trypsin degP - 3.4.21.107 ko:K04771,ko:K04772 ko01503,ko02020,map01503,map02020 M00728 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 - - - PDZ,PDZ_2,Trypsin_2 k59_538738_1 78245.Xaut_2572 2.38e-13 67.0 COG3795@1|root,COG3795@2|Bacteria,1RCZT@1224|Proteobacteria,2U735@28211|Alphaproteobacteria,3F1E4@335928|Xanthobacteraceae 28211|Alphaproteobacteria S YCII-related domain - - - - - - - - - - - - YCII k59_1393574_1 1101195.Meth11DRAFT_0535 3.27e-47 167.0 COG4963@1|root,COG4963@2|Bacteria,1R5SM@1224|Proteobacteria,2VKGQ@28216|Betaproteobacteria,2KKTW@206350|Nitrosomonadales 206350|Nitrosomonadales U Pilus assembly protein TadZ N-terminal - - - ko:K02282 - - - - ko00000,ko02035,ko02044 - - - TadZ_N k59_992659_1 1122137.AQXF01000006_gene715 9.37e-133 383.0 COG1344@1|root,COG1344@2|Bacteria,1MV1N@1224|Proteobacteria,2TUQQ@28211|Alphaproteobacteria 28211|Alphaproteobacteria N Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella flaA GO:0005575,GO:0005576,GO:0005623,GO:0009288,GO:0042995,GO:0043226,GO:0043228,GO:0044464 - ko:K02406 ko02020,ko02040,ko04621,ko04626,ko05132,ko05134,map02020,map02040,map04621,map04626,map05132,map05134 - - - ko00000,ko00001,ko02035 - - - Flagellin_C,Flagellin_N k59_767096_1 316407.85676044 1.28e-154 450.0 COG2199@1|root,COG2200@1|root,COG2199@2|Bacteria,COG2200@2|Bacteria,1MUQV@1224|Proteobacteria,1RN0Q@1236|Gammaproteobacteria,3XMX0@561|Escherichia 1236|Gammaproteobacteria T Serves as a specificity factor required for RNase E- mediated decay of the small global regulatory RNAs CsrB and CsrC, it is probably not a nuclease. Nor does its activity involve c-di- GMP, despite its domain composition. Positively modulates motility gene expression, is also required for curli expression csrD GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016020,GO:0016043,GO:0016070,GO:0019219,GO:0019222,GO:0019439,GO:0022607,GO:0031323,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044464,GO:0046483,GO:0046700,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0060255,GO:0065003,GO:0065007,GO:0071704,GO:0071840,GO:0071944,GO:0080090,GO:0090304,GO:1901360,GO:1901361,GO:1901575 - ko:K18765 - - - - ko00000,ko03019 - - - EAL,GAPES4,GGDEF k59_38406_1 987059.RBXJA2T_15348 2.7e-13 69.3 COG1014@1|root,COG4231@1|root,COG1014@2|Bacteria,COG4231@2|Bacteria,1MUKS@1224|Proteobacteria,2VJGC@28216|Betaproteobacteria,1KJ79@119065|unclassified Burkholderiales 28216|Betaproteobacteria C oxidoreductase - - 1.2.7.8 ko:K04090 - - - - br01601,ko00000,ko01000 - - - POR,TPP_enzyme_C k59_38406_2 522306.CAP2UW1_4335 5.59e-41 144.0 COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,2VHD3@28216|Betaproteobacteria,1KQJH@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria C Acyl-CoA dehydrogenase, C-terminal domain ivd - 1.3.8.4 ko:K00253 ko00280,ko01100,map00280,map01100 M00036 R04095 RC00246 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_603136_1 573413.Spirs_2249 1.28e-38 154.0 COG1593@1|root,COG3090@1|root,COG1593@2|Bacteria,COG3090@2|Bacteria,2J5NW@203691|Spirochaetes 203691|Spirochaetes G transporter, DctM subunit - - - - - - - - - - - - DctM,DctQ k59_826024_1 452662.SJA_C1-32580 5.84e-41 138.0 COG2127@1|root,COG2127@2|Bacteria,1MZU8@1224|Proteobacteria,2U982@28211|Alphaproteobacteria,2K5BT@204457|Sphingomonadales 204457|Sphingomonadales S Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation clpS - - ko:K06891 - - - - ko00000 - - - ClpS k59_826024_2 1265503.KB905164_gene1788 1.76e-42 145.0 COG4922@1|root,COG4922@2|Bacteria,1RDM5@1224|Proteobacteria,1TD7W@1236|Gammaproteobacteria,2Q86I@267889|Colwelliaceae 1236|Gammaproteobacteria S SnoaL-like polyketide cyclase - - - - - - - - - - - - SnoaL_2 k59_1782526_1 565045.NOR51B_2335 7.65e-106 314.0 COG1062@1|root,COG1062@2|Bacteria,1MUK4@1224|Proteobacteria,1RNQ4@1236|Gammaproteobacteria,1J4MG@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily adhC GO:0003674,GO:0003824,GO:0004022,GO:0004024,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0008150,GO:0008152,GO:0008270,GO:0009056,GO:0009636,GO:0009987,GO:0010033,GO:0016491,GO:0016614,GO:0016616,GO:0016999,GO:0017001,GO:0017144,GO:0042221,GO:0042802,GO:0043167,GO:0043169,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046185,GO:0046292,GO:0046294,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0051903,GO:0055114,GO:0070887,GO:0071704,GO:0097237,GO:0098754,GO:0110095,GO:0110096,GO:1901575,GO:1901700,GO:1901701,GO:1990748 1.1.1.1,1.1.1.284 ko:K00121 ko00010,ko00071,ko00350,ko00625,ko00626,ko00680,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,ko05204,map00010,map00071,map00350,map00625,map00626,map00680,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01200,map01220,map05204 - R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R06983,R07105,R08281,R08306,R08310 RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01715,RC01734,RC02273 ko00000,ko00001,ko01000 - - iEC042_1314.EC042_0393,iEC55989_1330.EC55989_0365,iECH74115_1262.ECH74115_0431,iECIAI1_1343.ECIAI1_0357,iECIAI39_1322.ECIAI39_0322,iECO103_1326.ECO103_0338,iECO111_1330.ECO111_0392,iECO26_1355.ECO26_0392,iECSE_1348.ECSE_0381,iECSP_1301.ECSP_0420,iECUMN_1333.ECUMN_0399,iECW_1372.ECW_m0434,iECs_1301.ECs0411,iEKO11_1354.EKO11_3486,iETEC_1333.ETEC_0412,iEcE24377_1341.EcE24377A_0381,iEcHS_1320.EcHS_A0421,iEcolC_1368.EcolC_3269,iG2583_1286.G2583_0469,iSSON_1240.SSON_0335,iSbBS512_1146.SbBS512_E0271,iUMNK88_1353.UMNK88_407,iWFL_1372.ECW_m0434,iZ_1308.Z0456 ADH_N,ADH_zinc_N k59_94129_1 743718.Isova_0651 4.01e-109 350.0 COG0086@1|root,COG0086@2|Bacteria,2GKWF@201174|Actinobacteria,4F38B@85017|Promicromonosporaceae 201174|Actinobacteria K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoC GO:0000428,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0030880,GO:0032991,GO:0040007,GO:0044424,GO:0044464,GO:0061695,GO:0071944,GO:1902494,GO:1990234 2.7.7.6 ko:K03046 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5 k59_1394675_1 436308.Nmar_1309 3.1e-73 240.0 COG1042@1|root,arCOG01338@2157|Archaea,arCOG01340@2157|Archaea,41S7I@651137|Thaumarchaeota 651137|Thaumarchaeota C Succinyl-CoA ligase like flavodoxin domain - - - ko:K18594 ko00720,ko01120,map00720,map01120 - R03157 RC00004,RC00014 ko00000,ko00001,ko01000 - - - ATP-grasp_5,CoA_binding_2,Succ_CoA_lig k59_148150_1 1268237.G114_06852 4.21e-34 129.0 COG3005@1|root,COG3005@2|Bacteria,1R4UP@1224|Proteobacteria,1RZUI@1236|Gammaproteobacteria 1236|Gammaproteobacteria C cytochrome C family protein - - - - - - - - - - - - Cytochrome_C554,Paired_CXXCH_1 k59_148150_2 349124.Hhal_2379 6.09e-10 67.8 2DT83@1|root,33J44@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_1275522_1 1054213.HMPREF9946_00675 1.88e-60 202.0 COG4589@1|root,COG4589@2|Bacteria,1MX58@1224|Proteobacteria,2TT9I@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Phosphatidate cytidylyltransferase cdsA2 - 2.7.7.41 ko:K00981 ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070 M00093 R01799 RC00002 ko00000,ko00001,ko00002,ko01000 - - - CTP_transf_1 k59_321638_1 1229909.NSED_05010 1.08e-47 160.0 arCOG10561@1|root,arCOG10561@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_148154_1 349124.Hhal_1466 2.27e-81 253.0 COG0052@1|root,COG0052@2|Bacteria,1MU33@1224|Proteobacteria,1RN0Z@1236|Gammaproteobacteria,1WW47@135613|Chromatiales 135613|Chromatiales J Belongs to the universal ribosomal protein uS2 family rpsB - - ko:K02967 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S2 k59_886435_1 553177.CAPSP0001_2206 9.83e-07 56.6 2E4EE@1|root,30UR1@2|Bacteria,4PFPE@976|Bacteroidetes,1IFEF@117743|Flavobacteriia,1ESVZ@1016|Capnocytophaga 976|Bacteroidetes - - - - - - - - - - - - - - - k59_886435_2 1392490.JHZX01000001_gene837 2.22e-44 159.0 COG4166@1|root,COG4166@2|Bacteria,4NFT5@976|Bacteroidetes,1HWV6@117743|Flavobacteriia 976|Bacteroidetes E ABC-type dipeptide transport system periplasmic component - - - ko:K02035 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - SBP_bac_5 k59_1565007_1 717605.Theco_2180 6.96e-19 94.4 COG0515@1|root,COG2815@1|root,COG0515@2|Bacteria,COG2815@2|Bacteria,1TP3F@1239|Firmicutes,4H9KD@91061|Bacilli,26TP2@186822|Paenibacillaceae 91061|Bacilli KLT serine threonine protein kinase prkC GO:0002237,GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005488,GO:0005539,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009605,GO:0009607,GO:0009617,GO:0009719,GO:0009847,GO:0009987,GO:0010033,GO:0010243,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019538,GO:0023052,GO:0032494,GO:0032502,GO:0036211,GO:0042221,GO:0042834,GO:0043170,GO:0043207,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051704,GO:0051707,GO:0051716,GO:0065007,GO:0070887,GO:0071216,GO:0071219,GO:0071224,GO:0071310,GO:0071417,GO:0071495,GO:0071704,GO:0071944,GO:0097367,GO:0140096,GO:1901564,GO:1901698,GO:1901699,GO:1901700,GO:1901701 2.7.11.1 ko:K08884,ko:K12132 - - - - ko00000,ko01000,ko01001 - - - PASTA,Pkinase k59_716104_1 84531.JMTZ01000138_gene4257 1.32e-69 221.0 COG0842@1|root,COG0842@2|Bacteria,1MW5R@1224|Proteobacteria,1RPB4@1236|Gammaproteobacteria,1X3TB@135614|Xanthomonadales 135614|Xanthomonadales V Transport permease protein - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_3 k59_377946_2 930169.B5T_00361 3.25e-73 236.0 COG0834@1|root,COG0834@2|Bacteria,1NN6F@1224|Proteobacteria,1RZ35@1236|Gammaproteobacteria,1XPVT@135619|Oceanospirillales 135619|Oceanospirillales ET COG0834 ABC-type amino acid transport signal transduction systems, periplasmic component domain - - - - - - - - - - - - Lig_chan,SBP_bac_3 k59_716109_1 436308.Nmar_1792 7.58e-154 446.0 COG0459@1|root,arCOG01257@2157|Archaea,41SDG@651137|Thaumarchaeota 651137|Thaumarchaeota O PFAM TCP-1 cpn60 chaperonin family - - - ko:K22447 - - - - ko00000,ko03110 - - - Cpn60_TCP1 k59_1107035_1 443144.GM21_4047 3.44e-106 318.0 COG3547@1|root,COG3547@2|Bacteria,1MXKJ@1224|Proteobacteria,42RYH@68525|delta/epsilon subdivisions,2WNT0@28221|Deltaproteobacteria 28221|Deltaproteobacteria L PFAM transposase IS116 IS110 IS902 family - - - ko:K07486 - - - - ko00000 - - - DEDD_Tnp_IS110,Transposase_20 k59_94145_1 1408419.JHYG01000005_gene556 8.12e-40 144.0 COG0161@1|root,COG0161@2|Bacteria,1MU2N@1224|Proteobacteria,2TQND@28211|Alphaproteobacteria,2JPWS@204441|Rhodospirillales 204441|Rhodospirillales E Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family bioA - 2.6.1.62 ko:K00833 ko00780,ko01100,map00780,map01100 M00123,M00573,M00577 R03231 RC00006,RC00887 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 k59_94145_2 1279038.KB907341_gene1793 2.17e-08 55.5 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,2U2KJ@28211|Alphaproteobacteria,2JQZ0@204441|Rhodospirillales 204441|Rhodospirillales NT Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - CZB,MCPsignal,Protoglobin k59_321673_1 246194.CHY_0233 6.66e-38 145.0 28I8B@1|root,2Z8B5@2|Bacteria 2|Bacteria C PFAM Cytochrome c, bacterial - - - - - - - - - - - - Cu-binding_MopE,Cytochrome_C554,Cytochrome_cB k59_321673_2 1141663.OOC_16279 1.53e-19 85.9 COG3005@1|root,COG3005@2|Bacteria,1MWV2@1224|Proteobacteria,1RQ9A@1236|Gammaproteobacteria,3Z860@586|Providencia 1236|Gammaproteobacteria C Cytochrome c-type protein napC GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0022900,GO:0031224,GO:0044237,GO:0044425,GO:0044464,GO:0045333,GO:0055114,GO:0071944 - ko:K02569 - - - - ko00000 - - iEcolC_1368.EcolC_1448 Cytochrom_NNT k59_1445750_1 1453501.JELR01000001_gene2693 2.11e-55 184.0 COG0845@1|root,COG0845@2|Bacteria,1MW65@1224|Proteobacteria,1RRHG@1236|Gammaproteobacteria,465HC@72275|Alteromonadaceae 1236|Gammaproteobacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - - - - - - - - - - Biotin_lipoyl_2,HlyD_D23 k59_1445750_2 1122194.AUHU01000005_gene812 1.5e-59 206.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,4648N@72275|Alteromonadaceae 1236|Gammaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K18138 ko01501,ko01503,map01501,map01503 M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000 2.A.6.2 - - ACR_tran k59_1445755_1 1144305.PMI02_05167 1.6e-80 243.0 COG5517@1|root,COG5517@2|Bacteria,1NEIT@1224|Proteobacteria,2UHF5@28211|Alphaproteobacteria,2KDHE@204457|Sphingomonadales 204457|Sphingomonadales Q SnoaL-like domain - - - - - - - - - - - - SnoaL_4 k59_321685_1 1041146.ATZB01000032_gene445 6.04e-10 62.0 COG1309@1|root,COG1309@2|Bacteria,1N6WG@1224|Proteobacteria,2UG93@28211|Alphaproteobacteria,4BBX6@82115|Rhizobiaceae 28211|Alphaproteobacteria K Bacterial regulatory proteins, tetR family - - - ko:K16137 - - - - ko00000,ko03000 - - - TetR_C_13,TetR_N k59_992734_1 90814.KL370891_gene747 1.15e-33 119.0 2BZMS@1|root,32Z9B@2|Bacteria,1NCFD@1224|Proteobacteria,1SPFN@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Protein of unknown function (DUF3467) - - - - - - - - - - - - DUF3467 k59_992734_2 1077974.GOEFS_045_00210 4.84e-06 48.5 COG1024@1|root,COG1024@2|Bacteria,2GJDK@201174|Actinobacteria,4GCW2@85026|Gordoniaceae 201174|Actinobacteria I Enoyl-CoA hydratase/isomerase - - - - - - - - - - - - ECH_1 k59_937369_2 436308.Nmar_0195 1.23e-15 72.4 arCOG08822@1|root,arCOG08822@2157|Archaea 436308.Nmar_0195|- - - - - - - - - - - - - - - - k59_1730627_1 338966.Ppro_3410 2.21e-09 63.5 COG0515@1|root,COG2202@1|root,COG2203@1|root,COG3899@1|root,COG4191@1|root,COG0515@2|Bacteria,COG2202@2|Bacteria,COG2203@2|Bacteria,COG3899@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,43BKN@68525|delta/epsilon subdivisions,2WJNS@28221|Deltaproteobacteria 28221|Deltaproteobacteria KLT AAA ATPase domain - - - - - - - - - - - - AAA_16,GAF,HATPase_c,Pkinase k59_539789_1 203122.Sde_1802 6.41e-122 357.0 COG2871@1|root,COG2871@2|Bacteria,1QTUV@1224|Proteobacteria,1RPG5@1236|Gammaproteobacteria,4648D@72275|Alteromonadaceae 1236|Gammaproteobacteria C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway nqrF GO:0000166,GO:0003674,GO:0003824,GO:0003954,GO:0005488,GO:0005575,GO:0006810,GO:0006811,GO:0006812,GO:0006814,GO:0008137,GO:0008150,GO:0008152,GO:0015672,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0030001,GO:0030964,GO:0032991,GO:0036094,GO:0043167,GO:0043168,GO:0044425,GO:0048037,GO:0050136,GO:0050660,GO:0050662,GO:0051179,GO:0051234,GO:0051536,GO:0051537,GO:0051540,GO:0055114,GO:0071949,GO:0097159,GO:0098796,GO:1901265,GO:1901363,GO:1902494 1.6.5.8 ko:K00351 - - - - ko00000,ko01000 - - - FAD_binding_6,Fer2,NAD_binding_1 k59_716140_1 243924.LT42_07400 1.1e-05 50.8 COG1670@1|root,COG1670@2|Bacteria,1NH44@1224|Proteobacteria,1S1ZW@1236|Gammaproteobacteria 1236|Gammaproteobacteria J Acetyltransferase ykkB - - - - - - - - - - - Acetyltransf_3 k59_767176_2 1255043.TVNIR_1377 1.95e-58 186.0 COG1573@1|root,COG1573@2|Bacteria,1MW91@1224|Proteobacteria,1S2B6@1236|Gammaproteobacteria,1X0E4@135613|Chromatiales 135613|Chromatiales L Uracil DNA glycosylase superfamily - - 3.2.2.27 ko:K21929 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - UDG k59_1507744_2 743720.Psefu_0291 5.52e-24 93.6 COG1758@1|root,COG1758@2|Bacteria,1N6TX@1224|Proteobacteria,1SCSR@1236|Gammaproteobacteria,1YZ2J@136845|Pseudomonas putida group 1236|Gammaproteobacteria K Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits rpoZ GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0030880,GO:0032774,GO:0032991,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234 2.7.7.6 ko:K03060 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb6 k59_38496_1 279238.Saro_1727 3.07e-74 248.0 COG3250@1|root,COG3250@2|Bacteria,1P9KJ@1224|Proteobacteria,2TV5M@28211|Alphaproteobacteria,2K34U@204457|Sphingomonadales 204457|Sphingomonadales G alpha-L-rhamnosidase - - - - - - - - - - - - Glyco_hydro_106 k59_826146_2 531844.FIC_01487 2.18e-34 123.0 COG0454@1|root,COG0456@2|Bacteria,4NNJS@976|Bacteroidetes,1I258@117743|Flavobacteriia,406M1@61432|unclassified Flavobacteriaceae 976|Bacteroidetes K Acetyltransferase (GNAT) domain - - 2.3.1.57 ko:K00657 ko00330,ko01100,ko04216,map00330,map01100,map04216 M00135 R01154 RC00004,RC00096 ko00000,ko00001,ko00002,ko01000 - - - Acetyltransf_1 k59_1445799_1 1229909.NSED_04285 1.25e-184 518.0 COG1759@1|root,arCOG04346@2157|Archaea,41S79@651137|Thaumarchaeota 651137|Thaumarchaeota F Domain of unknown function (DUF1297) - - 6.3.4.23 ko:K06863 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R06975 RC00263,RC00323 ko00000,ko00001,ko00002,ko01000 - - - DUF1246,DUF1297 k59_826155_1 1122137.AQXF01000002_gene477 9.51e-80 254.0 COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2TR2W@28211|Alphaproteobacteria 28211|Alphaproteobacteria IQ COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II - - - - - - - - - - - - AMP-binding,AMP-binding_C k59_1782612_1 1318628.MARLIPOL_15177 6.37e-66 212.0 COG0019@1|root,COG0019@2|Bacteria,1MUA6@1224|Proteobacteria,1RMI2@1236|Gammaproteobacteria,4641G@72275|Alteromonadaceae 1236|Gammaproteobacteria E Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine lysA GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008836,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016829,GO:0016830,GO:0016831,GO:0019752,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046451,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.1.1.20 ko:K01586 ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R00451 RC00299 ko00000,ko00001,ko00002,ko01000 - - - Orn_Arg_deC_N,Orn_DAP_Arg_deC k59_492567_1 1168065.DOK_13294 2.74e-26 114.0 COG0591@1|root,COG4191@1|root,COG0591@2|Bacteria,COG4191@2|Bacteria,1QTSW@1224|Proteobacteria,1T1G2@1236|Gammaproteobacteria,1J4PP@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T COG0591 Na proline symporter cbrA - - - - - - - - - - - HATPase_c,HisKA,PAS k59_213298_1 247639.MGP2080_12708 1.19e-78 249.0 COG1902@1|root,COG1902@2|Bacteria,1MVE0@1224|Proteobacteria,1RNM8@1236|Gammaproteobacteria 1236|Gammaproteobacteria C COG1902 NADH flavin oxidoreductases, Old Yellow Enzyme family - - 1.3.1.34 ko:K00219 - - - - ko00000,ko01000 - - - Oxidored_FMN k59_1572833_1 1449049.JONW01000012_gene146 1.01e-17 87.8 COG0642@1|root,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria 1224|Proteobacteria T Histidine kinase torS GO:0000155,GO:0000160,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0004721,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006464,GO:0006468,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009061,GO:0009987,GO:0010033,GO:0015980,GO:0016020,GO:0016301,GO:0016310,GO:0016311,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0016787,GO:0016788,GO:0016791,GO:0016853,GO:0016866,GO:0016868,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0023014,GO:0023052,GO:0035556,GO:0036211,GO:0042221,GO:0042578,GO:0042802,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0045333,GO:0046777,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0055114,GO:0065007,GO:0070887,GO:0071310,GO:0071704,GO:0071944,GO:0140096,GO:1901564 2.7.13.3 ko:K07647,ko:K20974 ko02020,ko02025,map02020,map02025 M00455,M00820 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - DUF2222,HAMP,HATPase_c,HisKA,Hpt,Response_reg k59_663177_1 887898.HMPREF0551_1098 6.28e-14 76.6 COG3170@1|root,COG3170@2|Bacteria,1MXV7@1224|Proteobacteria,2VHX1@28216|Betaproteobacteria,1K1CC@119060|Burkholderiaceae 28216|Betaproteobacteria NU pilus assembly protein FimV fimV - - ko:K08086 - - - - ko00000 - - - LysM k59_1284023_1 391587.KAOT1_21442 4.32e-108 327.0 COG4147@1|root,COG4147@2|Bacteria,4NHPT@976|Bacteroidetes,1HXQN@117743|Flavobacteriia 976|Bacteroidetes S Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family actP - - ko:K14393 - - - - ko00000,ko02000 2.A.21.7 - - SSF k59_1284023_2 984262.SGRA_3443 2.18e-05 43.9 COG4327@1|root,COG4327@2|Bacteria,4NSV7@976|Bacteroidetes 976|Bacteroidetes S solute sodium symporter, small subunit - - - - - - - - - - - - DUF4212 k59_1737972_1 1265505.ATUG01000001_gene4659 8.87e-29 114.0 COG1638@1|root,COG1638@2|Bacteria,1PJFW@1224|Proteobacteria,42PXK@68525|delta/epsilon subdivisions,2WJFU@28221|Deltaproteobacteria,2MJCH@213118|Desulfobacterales 28221|Deltaproteobacteria G PFAM Bacterial extracellular solute-binding protein, family 7 - - - - - - - - - - - - DctP k59_833712_1 1144305.PMI02_00199 1.44e-47 169.0 COG3243@1|root,COG3243@2|Bacteria,1MU68@1224|Proteobacteria,2TR7S@28211|Alphaproteobacteria,2K0U9@204457|Sphingomonadales 204457|Sphingomonadales I poly(R)-hydroxyalkanoic acid synthase phaC - - ko:K03821 ko00650,map00650 - R04254 RC00004 ko00000,ko00001,ko01000 - - - Abhydrolase_1,PhaC_N k59_833712_2 1088721.NSU_2455 5.59e-56 185.0 COG0436@1|root,COG0436@2|Bacteria,1MWS8@1224|Proteobacteria,2TRE3@28211|Alphaproteobacteria,2K0GY@204457|Sphingomonadales 204457|Sphingomonadales E Aminotransferase - - - ko:K14261 - - - - ko00000,ko01000,ko01007 - - - Aminotran_1_2 k59_1062158_1 159450.NH14_27745 2.44e-45 162.0 COG1858@1|root,COG1858@2|Bacteria,1MV70@1224|Proteobacteria,2VI1Z@28216|Betaproteobacteria,1K385@119060|Burkholderiaceae 28216|Betaproteobacteria C Di-haem cytochrome c peroxidase ccp GO:0005575,GO:0005623,GO:0042597,GO:0044464 1.11.1.5 ko:K00428 - - - - ko00000,ko01000 - - - CCP_MauG,Cytochrom_C k59_436899_1 1040986.ATYO01000006_gene457 2.48e-40 142.0 COG0231@1|root,COG0231@2|Bacteria,1MW2J@1224|Proteobacteria,2TUWE@28211|Alphaproteobacteria,43IN7@69277|Phyllobacteriaceae 28211|Alphaproteobacteria J Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase efp - - ko:K02356 - - - - ko00000,ko03012 - - - EFP,EFP_N,Elong-fact-P_C k59_385897_1 1056820.KB900655_gene3651 3.03e-114 329.0 COG0231@1|root,COG0231@2|Bacteria,1MW2J@1224|Proteobacteria,1RPW7@1236|Gammaproteobacteria,2PN5W@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria J Elongation factor P, C-terminal efp GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006414,GO:0006417,GO:0006448,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0017148,GO:0019222,GO:0019538,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0034248,GO:0034249,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0045900,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0071704,GO:0072344,GO:0080090,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:2000112,GO:2000113,GO:2001124,GO:2001125 - ko:K02356 - - - - ko00000,ko03012 - - - EFP,EFP_N,Elong-fact-P_C k59_774811_1 1121921.KB898711_gene1917 1.57e-85 263.0 COG1805@1|root,COG1805@2|Bacteria,1QTUU@1224|Proteobacteria,1RMGH@1236|Gammaproteobacteria,2PMI2@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria C NQR2, RnfD, RnfE family nqrB GO:0000166,GO:0003674,GO:0003824,GO:0003954,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006814,GO:0008137,GO:0008144,GO:0008150,GO:0008152,GO:0010181,GO:0015672,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0019842,GO:0030001,GO:0030964,GO:0032553,GO:0032991,GO:0036094,GO:0043167,GO:0043168,GO:0044425,GO:0044464,GO:0048037,GO:0050136,GO:0050662,GO:0051179,GO:0051234,GO:0055114,GO:0071944,GO:0097159,GO:0097367,GO:0098796,GO:1901265,GO:1901363,GO:1902444,GO:1902494 1.6.5.8 ko:K00347 - - - - ko00000,ko01000 - - - NQR2_RnfD_RnfE k59_1284038_1 411154.GFO_0493 7.68e-84 261.0 COG0004@1|root,COG0004@2|Bacteria,4NDV2@976|Bacteroidetes,1HYDV@117743|Flavobacteriia 976|Bacteroidetes P Ammonium Transporter - - - ko:K03320 - - - - ko00000,ko02000 1.A.11 - - Ammonium_transp k59_272294_1 395493.BegalDRAFT_1364 8.05e-23 102.0 COG1305@1|root,COG1305@2|Bacteria,1MWCE@1224|Proteobacteria,1RPH9@1236|Gammaproteobacteria,45ZZC@72273|Thiotrichales 72273|Thiotrichales E PFAM Transglutaminase-like superfamily - - 2.3.2.13 ko:K22452 - - - - ko00000,ko01000 - - - DUF3488,DUF4129,Transglut_core k59_664194_1 637905.SVI_3610 1.05e-77 246.0 COG3203@1|root,COG3203@2|Bacteria,1R5I5@1224|Proteobacteria,1RM86@1236|Gammaproteobacteria,2Q904@267890|Shewanellaceae 1236|Gammaproteobacteria M PFAM phosphate-selective porin O and P - - - - - - - - - - - - Porin_4,Porin_O_P k59_102574_1 981384.AEYW01000003_gene1995 1.63e-37 140.0 COG1574@1|root,COG1574@2|Bacteria,1R53N@1224|Proteobacteria,2VF84@28211|Alphaproteobacteria,4NBCU@97050|Ruegeria 28211|Alphaproteobacteria S Amidohydrolase family - - - - - - - - - - - - Amidohydro_3 k59_1516338_1 43989.cce_1451 2.75e-69 228.0 COG2303@1|root,COG2303@2|Bacteria,1G58P@1117|Cyanobacteria 1117|Cyanobacteria E GMC oxidoreductase - - - - - - - - - - - - DUF1080,GMC_oxred_C k59_1001842_1 269797.Mbar_A1663 9.4e-97 293.0 COG1228@1|root,arCOG00696@2157|Archaea,2XWAY@28890|Euryarchaeota 28890|Euryarchaeota Q COG1228 Imidazolonepropionase and related amidohydrolases - - - - - - - - - - - - Amidohydro_1 k59_493436_1 1232410.KI421421_gene3688 2.12e-72 231.0 COG1030@1|root,COG1030@2|Bacteria,1MUJN@1224|Proteobacteria,42MWM@68525|delta/epsilon subdivisions,2WK3H@28221|Deltaproteobacteria,43SBZ@69541|Desulfuromonadales 28221|Deltaproteobacteria O NfeD-like C-terminal, partner-binding nfeD - - ko:K07403 - - - - ko00000 - - - CLP_protease,NfeD,SDH_sah k59_1791305_1 360911.EAT1b_0510 1.72e-53 181.0 COG0334@1|root,COG0334@2|Bacteria,1TQU2@1239|Firmicutes,4HAB2@91061|Bacilli,3WFE6@539002|Bacillales incertae sedis 91061|Bacilli E Belongs to the Glu Leu Phe Val dehydrogenases family ldh - 1.4.1.9 ko:K00263 ko00280,ko00290,ko01100,ko01110,ko01130,map00280,map00290,map01100,map01110,map01130 - R01088,R01434,R02196 RC00006,RC00036 ko00000,ko00001,ko01000 - - - ELFV_dehydrog,ELFV_dehydrog_N k59_272307_1 760192.Halhy_4898 2.53e-67 229.0 COG3250@1|root,COG3867@1|root,COG3250@2|Bacteria,COG3867@2|Bacteria,4NEWN@976|Bacteroidetes,1IRAX@117747|Sphingobacteriia 976|Bacteroidetes G Glycosyl hydrolases family 2, TIM barrel domain - - 3.2.1.23 ko:K01190 ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100 - R01105,R01678,R03355,R04783,R06114 RC00049,RC00452 ko00000,ko00001,ko01000 - - - BetaGal_dom4_5,DUF4982,Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N k59_386912_1 436308.Nmar_0474 3e-52 167.0 arCOG08735@1|root,arCOG08735@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_1230690_1 436308.Nmar_1774 2.65e-27 107.0 COG0462@1|root,arCOG00067@2157|Archaea,41SH1@651137|Thaumarchaeota 651137|Thaumarchaeota F Ribose-phosphate pyrophosphokinase - - 2.7.6.1 ko:K00948 ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230 M00005 R01049 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - Pribosyl_synth,Pribosyltran,Pribosyltran_N k59_1230690_2 436308.Nmar_1773 1.52e-46 163.0 COG0668@1|root,arCOG01568@2157|Archaea,41SYX@651137|Thaumarchaeota 651137|Thaumarchaeota M Mechanosensitive ion channel - - - ko:K05802 - - - - ko00000,ko02000 1.A.23.1.1 - - MS_channel k59_946057_1 1123279.ATUS01000001_gene932 7.87e-07 55.5 COG1309@1|root,COG1309@2|Bacteria,1MZ9E@1224|Proteobacteria,1S8XT@1236|Gammaproteobacteria,1J6GQ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria K Bacterial regulatory proteins, tetR family - - - ko:K18301 - M00642 - - ko00000,ko00002,ko01504,ko03000 - - - TetR_C_7,TetR_N k59_1681840_1 1266909.AUAG01000003_gene890 2.15e-09 57.8 COG0115@1|root,COG0115@2|Bacteria,1MVAT@1224|Proteobacteria,1RPU0@1236|Gammaproteobacteria,1WX40@135613|Chromatiales 135613|Chromatiales EH PFAM Aminotransferase, class IV - - 2.6.1.21 ko:K00824 ko00310,ko00330,ko00360,ko00472,ko00473,ko01100,map00310,map00330,map00360,map00472,map00473,map01100 - R01148,R01582,R02459,R02851,R02924,R05053 RC00006,RC00008,RC00025 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_4 k59_1681840_2 1283300.ATXB01000002_gene2825 4.07e-19 81.3 COG2921@1|root,COG2921@2|Bacteria,1PJDX@1224|Proteobacteria,1THTC@1236|Gammaproteobacteria,1XFN8@135618|Methylococcales 135618|Methylococcales S Belongs to the UPF0250 family - - - ko:K09158 - - - - ko00000 - - - DUF493 k59_1681840_3 935863.AWZR01000002_gene1006 1.05e-41 144.0 COG0321@1|root,COG0321@2|Bacteria,1MU6A@1224|Proteobacteria,1RMXQ@1236|Gammaproteobacteria,1X4H1@135614|Xanthomonadales 135614|Xanthomonadales H Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate lipB GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009249,GO:0009987,GO:0010467,GO:0018065,GO:0018193,GO:0018205,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0051604,GO:0071704,GO:1901564 2.3.1.181 ko:K03801 ko00785,ko01100,map00785,map01100 - R07766,R07769 RC00039,RC00992,RC02867 ko00000,ko00001,ko01000 - - - BPL_LplA_LipB k59_1626588_1 394221.Mmar10_0785 1.27e-39 142.0 COG0627@1|root,COG0627@2|Bacteria,1QIRQ@1224|Proteobacteria,2TUU5@28211|Alphaproteobacteria,43Z22@69657|Hyphomonadaceae 28211|Alphaproteobacteria S Putative esterase - - - - - - - - - - - - Esterase k59_1341274_1 225937.HP15_277 3.65e-87 275.0 COG0606@1|root,COG0606@2|Bacteria,1MU4R@1224|Proteobacteria,1RMB9@1236|Gammaproteobacteria,464ZX@72275|Alteromonadaceae 1236|Gammaproteobacteria O ATPase with chaperone activity comM - - ko:K07391 - - - - ko00000 - - - ChlI,Mg_chelatase,Mg_chelatase_C k59_214366_1 292.DM42_4462 3.03e-90 291.0 COG0657@1|root,COG2072@1|root,COG0657@2|Bacteria,COG2072@2|Bacteria,1MUQH@1224|Proteobacteria,2VHFH@28216|Betaproteobacteria,1KGMP@119060|Burkholderiaceae 28216|Betaproteobacteria IP Pfam:DUF2424 - - 1.14.13.160,1.14.13.22,1.14.13.226 ko:K03379,ko:K18371,ko:K21730 ko00640,ko00930,ko01120,ko01220,map00640,map00930,map01120,map01220 - R02231,R06622,R10704 RC00662,RC01550,RC03250 ko00000,ko00001,ko01000 - - - Abhydrolase_3,FMO-like,Pyr_redox_3 k59_46662_1 926559.JoomaDRAFT_3628 9.06e-78 239.0 COG1360@1|root,COG1360@2|Bacteria,4NHDJ@976|Bacteroidetes,1HWS7@117743|Flavobacteriia 976|Bacteroidetes N flagellar motor protein - - - ko:K02557 ko02030,ko02040,map02030,map02040 - - - ko00000,ko00001,ko02000,ko02035 1.A.30.1 - - OmpA k59_1791327_1 715451.ambt_19790 6.5e-88 263.0 COG0625@1|root,COG0625@2|Bacteria,1MUN3@1224|Proteobacteria,1RMF7@1236|Gammaproteobacteria,465TK@72275|Alteromonadaceae 1236|Gammaproteobacteria O Belongs to the GST superfamily yfcG - - ko:K11209 - - - - ko00000,ko01000 - - - GST_C,GST_N,GST_N_3 k59_1791327_2 706191.PANA_0104 2.9e-18 87.4 COG0625@1|root,COG0625@2|Bacteria,1RHSK@1224|Proteobacteria,1RR26@1236|Gammaproteobacteria,3VXXE@53335|Pantoea 1236|Gammaproteobacteria O Glutathione S-Transferase yibF GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 2.5.1.18 ko:K00799 ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418 - R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905 RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944 ko00000,ko00001,ko01000,ko02000 1.A.12.2.2,1.A.12.3.2 - - GST_C,GST_C_2,GST_N_3 k59_1174750_1 1122137.AQXF01000002_gene522 8.79e-124 360.0 COG0583@1|root,COG0583@2|Bacteria,1MWVB@1224|Proteobacteria,2TQXV@28211|Alphaproteobacteria 28211|Alphaproteobacteria K transcriptional regulator - - - - - - - - - - - - HTH_1,LysR_substrate k59_1001868_1 1268072.PSAB_07645 5.9e-45 161.0 COG0491@1|root,COG0491@2|Bacteria,1V8JE@1239|Firmicutes,4HIYW@91061|Bacilli,26VD8@186822|Paenibacillaceae 91061|Bacilli S Metallo-beta-lactamase superfamily - - - - - - - - - - - - Lactamase_B k59_437862_1 103690.17131772 1.37e-54 210.0 COG0500@1|root,COG0604@1|root,COG3321@1|root,COG0604@2|Bacteria,COG2226@2|Bacteria,COG3321@2|Bacteria,1FZXE@1117|Cyanobacteria,1HIGN@1161|Nostocales 1117|Cyanobacteria CQ acyl transferase domain - - - - - - - - - - - - ADH_N,ADH_zinc_N,ADH_zinc_N_2,AMP-binding,Acyl_transf_1,KAsynt_C_assoc,KR,Ketoacyl-synt_C,Methyltransf_12,PP-binding,PS-DH,ketoacyl-synt k59_1516362_1 436308.Nmar_1563 5.06e-59 191.0 COG1736@1|root,arCOG04112@2157|Archaea,41SE0@651137|Thaumarchaeota 651137|Thaumarchaeota J Diphthamide biosynthesis - - 2.5.1.108 ko:K07561 - - R10455 RC00021,RC03180 ko00000,ko01000,ko03012 - - - Diphthamide_syn k59_1681859_1 999141.GME_02630 1.41e-31 120.0 COG2148@1|root,COG2148@2|Bacteria,1MV6W@1224|Proteobacteria,1RMMN@1236|Gammaproteobacteria,1XHA3@135619|Oceanospirillales 135619|Oceanospirillales M COG2148 Sugar transferases involved in lipopolysaccharide synthesis wcaJ - 2.7.8.40 ko:K03606,ko:K21303 ko05111,map05111 - - - ko00000,ko00001,ko01000,ko01003,ko01005 - - - Bac_transf,CoA_binding_3 k59_1681859_2 1123368.AUIS01000005_gene435 6.09e-17 79.0 COG5652@1|root,COG5652@2|Bacteria,1NGE7@1224|Proteobacteria,1SGEP@1236|Gammaproteobacteria 1236|Gammaproteobacteria S PFAM VanZ - - - - - - - - - - - - VanZ k59_493468_1 396588.Tgr7_1538 4.23e-36 132.0 COG0077@1|root,COG1605@1|root,COG0077@2|Bacteria,COG1605@2|Bacteria,1MU60@1224|Proteobacteria,1RNRD@1236|Gammaproteobacteria,1WWFA@135613|Chromatiales 135613|Chromatiales E PFAM Prephenate dehydratase - - 4.2.1.51,5.4.99.5 ko:K14170 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00024,M00025 R00691,R01373,R01715 RC00360,RC03116 ko00000,ko00001,ko00002,ko01000 - - - ACT,CM_2,PDT k59_493468_2 1121374.KB891585_gene2395 4.72e-36 137.0 COG0188@1|root,COG0188@2|Bacteria,1MUGG@1224|Proteobacteria,1RN03@1236|Gammaproteobacteria 1236|Gammaproteobacteria L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrA GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003916,GO:0003918,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006265,GO:0006351,GO:0006725,GO:0006807,GO:0006996,GO:0008094,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017111,GO:0018130,GO:0019438,GO:0032774,GO:0034335,GO:0034641,GO:0034645,GO:0034654,GO:0042221,GO:0042493,GO:0042623,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051276,GO:0061505,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0097659,GO:0140097,GO:1901360,GO:1901362,GO:1901363,GO:1901576 5.99.1.3 ko:K02469 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseA_C,DNA_topoisoIV k59_1230729_1 583355.Caka_1495 1.14e-20 95.9 COG5607@1|root,COG5607@2|Bacteria,46UKR@74201|Verrucomicrobia 74201|Verrucomicrobia S CHAD - - - - - - - - - - - - CHAD k59_664240_1 1434929.X946_2858 7.51e-108 325.0 COG0043@1|root,COG0043@2|Bacteria,1MU62@1224|Proteobacteria,2VH09@28216|Betaproteobacteria,1JZXF@119060|Burkholderiaceae 28216|Betaproteobacteria H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol, an intermediate step in ubiquinone biosynthesis ubiD - 4.1.1.98 ko:K03182 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00117 R04985,R04986 RC00391 ko00000,ko00001,ko00002,ko01000 - - - UbiD k59_1063201_1 498211.CJA_1149 4.28e-81 259.0 COG0659@1|root,COG0659@2|Bacteria,1MVWV@1224|Proteobacteria,1RMCN@1236|Gammaproteobacteria,1FG68@10|Cellvibrio 1236|Gammaproteobacteria P Sulfate permease family ychM GO:0003333,GO:0003674,GO:0005215,GO:0005310,GO:0005326,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0006835,GO:0006836,GO:0006855,GO:0006865,GO:0008150,GO:0008272,GO:0008509,GO:0008514,GO:0015075,GO:0015103,GO:0015116,GO:0015138,GO:0015141,GO:0015171,GO:0015172,GO:0015179,GO:0015183,GO:0015238,GO:0015318,GO:0015556,GO:0015698,GO:0015711,GO:0015740,GO:0015741,GO:0015744,GO:0015800,GO:0015807,GO:0015810,GO:0015849,GO:0015893,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0042221,GO:0042493,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0070778,GO:0071422,GO:0071702,GO:0071705,GO:0071944,GO:0072348,GO:0098656,GO:0098660,GO:0098661,GO:1901682,GO:1902358,GO:1902475,GO:1903825,GO:1905039 - ko:K03321 - - - - ko00000,ko02000 2.A.53.3 - iSbBS512_1146.SbBS512_E1370 STAS,Sulfate_transp k59_1681877_1 930169.B5T_02623 3.53e-34 135.0 COG1305@1|root,COG1305@2|Bacteria,1MWCE@1224|Proteobacteria,1RPH9@1236|Gammaproteobacteria,1XHU5@135619|Oceanospirillales 135619|Oceanospirillales E COG1305 Transglutaminase-like enzymes - - 2.3.2.13 ko:K22452 - - - - ko00000,ko01000 - - - DUF3488,DUF4129,Transglut_core k59_1115969_2 1242864.D187_008792 1.53e-32 125.0 COG0568@1|root,COG0568@2|Bacteria,1MVNJ@1224|Proteobacteria,42N2S@68525|delta/epsilon subdivisions,2WJ0E@28221|Deltaproteobacteria,2YUHI@29|Myxococcales 28221|Deltaproteobacteria K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth rpoD - - ko:K03086 - - - - ko00000,ko03021 - - - Sigma70_ner,Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4 k59_1626637_1 1178825.ALIH01000019_gene1239 2.99e-110 319.0 28HFG@1|root,2Z7RJ@2|Bacteria,4NFNY@976|Bacteroidetes,1HWSC@117743|Flavobacteriia 976|Bacteroidetes S Domain of Unknown Function (DUF1599) - - - - - - - - - - - - DUF1599 k59_214412_1 472759.Nhal_3177 5.26e-146 452.0 COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,1MU7B@1224|Proteobacteria,1RN2W@1236|Gammaproteobacteria,1WWAR@135613|Chromatiales 135613|Chromatiales E glutamate synthase - - 1.4.1.13,1.4.1.14 ko:K00265 ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 - R00093,R00114,R00248 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - GATase_2,GXGXG,Glu_syn_central,Glu_synthase k59_1001925_1 396588.Tgr7_2192 1.38e-112 337.0 COG0247@1|root,COG0247@2|Bacteria,1NZIG@1224|Proteobacteria,1RYPW@1236|Gammaproteobacteria,1WXQI@135613|Chromatiales 135613|Chromatiales C 4Fe-4S dicluster domain - - - - - - - - - - - - CCG,Fer4_17,Fer4_8 k59_1115984_1 1122137.AQXF01000002_gene111 5.5e-132 375.0 COG0852@1|root,COG0852@2|Bacteria,1MX4B@1224|Proteobacteria,2TSMT@28211|Alphaproteobacteria 28211|Alphaproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoC GO:0003674,GO:0003824,GO:0003954,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0016655,GO:0050136,GO:0055114 1.6.5.3 ko:K00332 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_30kDa k59_437905_1 1223544.GSI01S_16_00560 5.13e-08 55.8 COG4875@1|root,COG4875@2|Bacteria,2I3P2@201174|Actinobacteria,4GEBB@85026|Gordoniaceae 201174|Actinobacteria S SnoaL-like domain - - 5.3.3.1 ko:K01822 ko00140,ko00984,ko01100,ko01120,map00140,map00984,map01100,map01120 M00107,M00110 R01837,R02216,R02499,R02840,R03327,R04163,R04678,R04849,R09955 RC00146,RC00762 ko00000,ko00001,ko00002,ko01000 - - - SnoaL_2 k59_437905_2 247634.GPB2148_2848 5.21e-46 154.0 COG1522@1|root,COG1522@2|Bacteria,1REZW@1224|Proteobacteria,1S552@1236|Gammaproteobacteria,1J5XG@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria K helix_turn_helix ASNC type - - - - - - - - - - - - AsnC_trans_reg,HTH_AsnC-type k59_437905_3 383381.EH30_10405 5.04e-46 154.0 COG1522@1|root,COG1522@2|Bacteria,1N5P1@1224|Proteobacteria,2UDBV@28211|Alphaproteobacteria,2K5TW@204457|Sphingomonadales 204457|Sphingomonadales K AsnC family transcriptional regulator - - - - - - - - - - - - AsnC_trans_reg,HTH_24,HTH_AsnC-type k59_437905_4 349520.PPE_03008 7.23e-16 79.0 COG4221@1|root,COG4221@2|Bacteria,1UIB4@1239|Firmicutes,4ITBS@91061|Bacilli,274QS@186822|Paenibacillaceae 91061|Bacilli S KR domain pksE - - - - - - - - - - - adh_short k59_1403941_1 545264.KB898751_gene2508 3.27e-16 77.4 COG0439@1|root,COG0439@2|Bacteria,1MU4H@1224|Proteobacteria,1T1GN@1236|Gammaproteobacteria,1WVX4@135613|Chromatiales 135613|Chromatiales I TIGRFAM acetyl-CoA carboxylase, biotin carboxylase - - 6.4.1.1 ko:K01959 ko00020,ko00620,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00720,map01100,map01120,map01200,map01230 M00173,M00620 R00344 RC00040,RC00367 ko00000,ko00001,ko00002,ko01000 - - - Biotin_carb_C,Biotin_carb_N,CPSase_L_D2 k59_272368_2 317013.NY99_06610 1e-33 133.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,1RMH0@1236|Gammaproteobacteria 1236|Gammaproteobacteria NT chemotaxis, protein - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - 4HB_MCP_1,HAMP,MCPsignal,PAS_4,sCache_2 k59_493500_1 1411685.U062_00376 8.47e-15 76.3 COG4206@1|root,COG4206@2|Bacteria,1QUGQ@1224|Proteobacteria,1T241@1236|Gammaproteobacteria,1J4Z0@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H COG1629 Outer membrane receptor proteins, mostly Fe transport - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_272369_1 1205680.CAKO01000040_gene955 5e-53 180.0 COG2141@1|root,COG2141@2|Bacteria,1MX64@1224|Proteobacteria,2TV8M@28211|Alphaproteobacteria,2JXBR@204441|Rhodospirillales 204441|Rhodospirillales C Luciferase-like monooxygenase - - - - - - - - - - - - Bac_luciferase k59_834872_1 436308.Nmar_0023 1.35e-111 322.0 COG0529@1|root,arCOG01040@2157|Archaea 2157|Archaea F Catalyzes the synthesis of activated sulfate cysC - 2.7.1.25 ko:K00860,ko:K07028 ko00230,ko00920,ko01100,ko01120,map00230,map00920,map01100,map01120 M00176 R00509,R04928 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - AAA_33,APS_kinase k59_272372_1 1122137.AQXF01000003_gene1923 1.05e-99 296.0 COG0224@1|root,COG0224@2|Bacteria,1MU28@1224|Proteobacteria,2TR11@28211|Alphaproteobacteria 28211|Alphaproteobacteria C Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex atpG - - ko:K02115 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt k59_549123_1 566466.NOR53_1757 1.79e-66 215.0 COG0624@1|root,COG0624@2|Bacteria,1MUSU@1224|Proteobacteria,1RNIW@1236|Gammaproteobacteria,1J5FR@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E COG0624 Acetylornithine deacetylase Succinyl-diaminopimelate desuccinylase and related deacylases cpg2_2 - 3.4.17.11 ko:K01295 - - - - ko00000,ko01000,ko01002 - - - M20_dimer,Peptidase_M20,Peptidase_M28 k59_834881_1 685778.AORL01000023_gene2111 2.48e-138 410.0 COG0308@1|root,COG0308@2|Bacteria,1MUV3@1224|Proteobacteria,2TVKQ@28211|Alphaproteobacteria,2K1RS@204457|Sphingomonadales 204457|Sphingomonadales E Peptidase family M1 domain - - - - - - - - - - - - Peptidase_M1 k59_330176_1 316407.4062476 4.45e-54 182.0 COG0583@1|root,COG0583@2|Bacteria,1MU2E@1224|Proteobacteria,1RYV3@1236|Gammaproteobacteria,3XQZP@561|Escherichia 1236|Gammaproteobacteria K sequence-specific DNA binding ycaN GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0005488,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031326,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1903506,GO:2000112,GO:2001141 - - - - - - - - - - HTH_1,LysR_substrate k59_214434_1 1248232.BANQ01000092_gene3089 1.21e-27 115.0 COG1208@1|root,COG1208@2|Bacteria,1P2A8@1224|Proteobacteria,1S213@1236|Gammaproteobacteria,1XWGK@135623|Vibrionales 135623|Vibrionales JM COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon - - - - - - - - - - - - - k59_1626665_1 76114.ebA2824 2.55e-52 180.0 COG0168@1|root,COG0168@2|Bacteria,1MUIJ@1224|Proteobacteria,2VH82@28216|Betaproteobacteria,2KUF7@206389|Rhodocyclales 206389|Rhodocyclales P Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA - - - ko:K03498 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - - TrkH k59_157199_1 637389.Acaty_c1974 4.47e-12 67.4 COG1192@1|root,COG1192@2|Bacteria,1QBJX@1224|Proteobacteria,1S739@1236|Gammaproteobacteria,2NCCZ@225057|Acidithiobacillales 225057|Acidithiobacillales D AAA domain - - - ko:K03496 - - - - ko00000,ko03036,ko04812 - - - CbiA k59_157199_2 290315.Clim_2014 1.12e-22 92.8 COG5652@1|root,COG5652@2|Bacteria,1FFNH@1090|Chlorobi 1090|Chlorobi S VanZ like family - - - - - - - - - - - - VanZ k59_1285122_1 335543.Sfum_1836 3.87e-17 81.6 COG2515@1|root,COG2515@2|Bacteria,1MVYF@1224|Proteobacteria,42PWI@68525|delta/epsilon subdivisions,2WKFE@28221|Deltaproteobacteria 28221|Deltaproteobacteria E TIGRFAM pyridoxal phosphate-dependent enzymes, D-cysteine desulfhydrase family - - 4.4.1.15 ko:K05396 ko00270,map00270 - R01874 RC00382 ko00000,ko00001,ko01000 - - - PALP k59_664319_1 870187.Thini_3964 1.89e-67 215.0 COG0264@1|root,COG0264@2|Bacteria,1MUS2@1224|Proteobacteria,1RPBJ@1236|Gammaproteobacteria,45ZY5@72273|Thiotrichales 72273|Thiotrichales J Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome tsf - - ko:K02357 - - - - ko00000,ko03012,ko03029 - - - EF_TS k59_50683_2 1500894.JQNN01000001_gene3985 7.54e-95 296.0 COG0337@1|root,COG0703@1|root,COG0337@2|Bacteria,COG0703@2|Bacteria,1MUBK@1224|Proteobacteria,2VHXR@28216|Betaproteobacteria,4725Y@75682|Oxalobacteraceae 28216|Betaproteobacteria E Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) aroB - 2.7.1.71,4.2.3.4 ko:K01735,ko:K13829 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02412,R03083 RC00002,RC00078,RC00847 ko00000,ko00001,ko00002,ko01000 - - - DHQ_synthase,SKI k59_1408048_1 84531.JMTZ01000075_gene2047 4.73e-08 61.2 COG3209@1|root,COG3209@2|Bacteria,1MVV1@1224|Proteobacteria,1RP75@1236|Gammaproteobacteria,1X4CP@135614|Xanthomonadales 135614|Xanthomonadales M RHS Repeat - - - - - - - - - - - - DUF4329,RHS_repeat k59_1742870_1 314287.GB2207_11798 2.08e-47 153.0 COG0234@1|root,COG0234@2|Bacteria,1MZ2X@1224|Proteobacteria,1S8YR@1236|Gammaproteobacteria,1J6G0@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter groS GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0010033,GO:0016032,GO:0016465,GO:0019058,GO:0019068,GO:0032991,GO:0035966,GO:0042221,GO:0042802,GO:0043167,GO:0043169,GO:0044403,GO:0044419,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046872,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0051704,GO:0061077,GO:0101031,GO:1990220 - ko:K04078 - - - - ko00000,ko03029,ko03110 - - - Cpn10 k59_1742870_2 1300350.DSW25_01620 9.3e-10 58.9 COG3030@1|root,COG3030@2|Bacteria,1MZJJ@1224|Proteobacteria,2UF72@28211|Alphaproteobacteria,3ZXDZ@60136|Sulfitobacter 28211|Alphaproteobacteria S FxsA cytoplasmic membrane protein fxsA - - ko:K07113 - - - - ko00000 - - - FxsA k59_899375_1 861299.J421_3771 8.54e-96 301.0 COG0280@1|root,COG0281@1|root,COG0280@2|Bacteria,COG0281@2|Bacteria,1ZT01@142182|Gemmatimonadetes 2|Bacteria C Phosphate acetyl/butaryl transferase maeB GO:0003674,GO:0003824,GO:0004470,GO:0004473,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016614,GO:0016615,GO:0016616,GO:0030145,GO:0043167,GO:0043169,GO:0046872,GO:0046914,GO:0055114 1.1.1.38,1.1.1.40,2.3.1.8 ko:K00027,ko:K00029,ko:K00625,ko:K13788 ko00430,ko00620,ko00640,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,ko02020,map00430,map00620,map00640,map00680,map00710,map00720,map01100,map01120,map01200,map02020 M00169,M00172,M00357,M00579 R00214,R00216,R00230,R00921 RC00004,RC00105,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_1637 Malic_M,PTA_PTB,malic k59_1345421_1 203122.Sde_0778 9.24e-115 353.0 COG3533@1|root,COG3533@2|Bacteria,1MWEN@1224|Proteobacteria,1RSMM@1236|Gammaproteobacteria,4646J@72275|Alteromonadaceae 1236|Gammaproteobacteria S Domain of unknown function - - - ko:K09955 - - - - ko00000 - - - DUF4986,Glyco_hydro_127 k59_219360_1 557599.MKAN_26415 1.47e-55 195.0 COG0013@1|root,COG0013@2|Bacteria,2GIUG@201174|Actinobacteria,233PU@1762|Mycobacteriaceae 201174|Actinobacteria J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain alaS GO:0003674,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016597,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0030312,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.7 ko:K01872 ko00970,map00970 M00359,M00360 R03038 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DHHA1,tRNA-synt_2c,tRNA_SAD k59_392293_1 1046724.KB889948_gene2191 9.8e-20 91.3 29USZ@1|root,30G58@2|Bacteria,1RGM2@1224|Proteobacteria,1S3U2@1236|Gammaproteobacteria,468SK@72275|Alteromonadaceae 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_1068168_2 765914.ThisiDRAFT_0885 3.6e-34 125.0 COG2413@1|root,COG2413@2|Bacteria,1QXNS@1224|Proteobacteria,1T4CP@1236|Gammaproteobacteria,1X2R4@135613|Chromatiales 135613|Chromatiales - - - - - - - - - - - - - - - k59_1235598_1 743721.Psesu_1325 3.55e-54 183.0 COG1609@1|root,COG1609@2|Bacteria,1MVUR@1224|Proteobacteria,1RN2K@1236|Gammaproteobacteria,1X3V1@135614|Xanthomonadales 135614|Xanthomonadales K transcriptional - - - ko:K02529 - - - - ko00000,ko03000 - - - LacI,Peripla_BP_3 k59_951226_1 1396141.BATP01000047_gene3950 1.1e-19 85.5 COG0776@1|root,COG0776@2|Bacteria,46XH3@74201|Verrucomicrobia,2IVWK@203494|Verrucomicrobiae 203494|Verrucomicrobiae L Bacterial DNA-binding protein - - - - - - - - - - - - Bac_DNA_binding k59_51824_1 1121923.GPUN_1367 5.43e-07 56.2 COG1391@1|root,COG1391@2|Bacteria,1MU4I@1224|Proteobacteria,1RP9N@1236|Gammaproteobacteria,464DC@72275|Alteromonadaceae 1236|Gammaproteobacteria H Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell glnE GO:0000166,GO:0000287,GO:0000820,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006521,GO:0006541,GO:0006542,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0008882,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0010565,GO:0016053,GO:0016740,GO:0016772,GO:0016779,GO:0017076,GO:0019222,GO:0019752,GO:0030554,GO:0031323,GO:0032553,GO:0032555,GO:0032559,GO:0033238,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046872,GO:0050789,GO:0050794,GO:0051171,GO:0062012,GO:0065007,GO:0070566,GO:0071704,GO:0080090,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.7.42,2.7.7.89 ko:K00982 - - - - ko00000,ko01000 - - - GlnD_UR_UTase,GlnE k59_554184_1 1232410.KI421427_gene1305 5.05e-105 315.0 COG1894@1|root,COG1894@2|Bacteria,1MV8F@1224|Proteobacteria,42N6N@68525|delta/epsilon subdivisions,2WJ1W@28221|Deltaproteobacteria,43SBB@69541|Desulfuromonadales 28221|Deltaproteobacteria C NADH-ubiquinone oxidoreductase-F iron-sulfur binding region nuoF-2 - 1.6.5.3 ko:K00334,ko:K00335 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - 2Fe-2S_thioredx,Complex1_51K,NADH_4Fe-4S,SLBB k59_392313_1 452637.Oter_1629 7.96e-20 88.6 COG0266@1|root,COG0266@2|Bacteria 2|Bacteria L class I DNA-(apurinic or apyrimidinic site) endonuclease activity fpg - 3.2.2.23,4.2.99.18 ko:K10563 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - Fapy_DNA_glyco,H2TH,zf-FPG_IleRS k59_730525_1 1545915.JROG01000001_gene593 7.67e-102 309.0 COG3409@1|root,COG4322@1|root,COG3409@2|Bacteria,COG4322@2|Bacteria,1N1X8@1224|Proteobacteria 1224|Proteobacteria M Uncharacterized protein conserved in bacteria (DUF2272) - - - - - - - - - - - - DUF1906,DUF2272 k59_554188_1 998674.ATTE01000001_gene2196 1.53e-99 303.0 COG0519@1|root,COG0519@2|Bacteria,1MU2A@1224|Proteobacteria,1RP81@1236|Gammaproteobacteria,45ZX7@72273|Thiotrichales 72273|Thiotrichales F Catalyzes the synthesis of GMP from XMP guaA - 6.3.5.2 ko:K01951 ko00230,ko00983,ko01100,map00230,map00983,map01100 M00050 R01230,R01231,R08244 RC00010,RC00204 ko00000,ko00001,ko00002,ko01000,ko01002 - - - GATase,GMP_synt_C,NAD_synthase k59_900491_1 1229909.NSED_02910 7.71e-16 71.6 arCOG14076@1|root,arCOG14076@2157|Archaea 1229909.NSED_02910|- - - - - - - - - - - - - - - - k59_900491_2 269797.Mbar_A0825 4.87e-05 46.6 COG0589@1|root,arCOG02053@2157|Archaea,2XX8Y@28890|Euryarchaeota,2N9XS@224756|Methanomicrobia 224756|Methanomicrobia T Universal stress protein family - - - - - - - - - - - - Usp k59_51839_1 1112214.AHIS01000063_gene2734 3.17e-76 253.0 COG1629@1|root,COG4771@2|Bacteria,1MUNK@1224|Proteobacteria,2TRCG@28211|Alphaproteobacteria,2K0ND@204457|Sphingomonadales 204457|Sphingomonadales P receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_1006897_2 1030157.AFMP01000043_gene1680 1.5e-42 156.0 COG0312@1|root,COG0312@2|Bacteria,1MUVW@1224|Proteobacteria,2TSAV@28211|Alphaproteobacteria,2K048@204457|Sphingomonadales 204457|Sphingomonadales S modulator of DNA gyrase pmbA - - ko:K03592 - - - - ko00000,ko01002 - - - PmbA_TldD k59_900496_2 1423775.BAMN01000003_gene1758 6.18e-06 49.3 COG1396@1|root,COG5294@1|root,COG1396@2|Bacteria,COG5294@2|Bacteria,1W1Q8@1239|Firmicutes,4I0U9@91061|Bacilli,3F7V4@33958|Lactobacillaceae 91061|Bacilli K Helix-turn-helix domain - - - - - - - - - - - - HTH_3 k59_1460061_1 1123519.PSJM300_15850 3.15e-48 168.0 COG2244@1|root,COG2244@2|Bacteria,1MUN5@1224|Proteobacteria,1RRAJ@1236|Gammaproteobacteria,1Z2K6@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria S COG2244 Membrane protein involved in the export of O-antigen and teichoic acid wzx - - - - - - - - - - - Polysacc_synt,Polysacc_synt_3,Polysacc_synt_C k59_1460061_2 1499686.BN1079_02319 1.69e-17 83.6 COG2327@1|root,COG2327@2|Bacteria,1RBZ1@1224|Proteobacteria,1S2CC@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Polysaccharide pyruvyl transferase - - - ko:K16710 - - - - ko00000 - - - PS_pyruv_trans k59_1179908_1 1197477.IA57_06880 8.59e-91 278.0 COG1748@1|root,COG1748@2|Bacteria,4NFM8@976|Bacteroidetes,1HXRS@117743|Flavobacteriia 976|Bacteroidetes E Saccharopine dehydrogenase - - 1.5.1.10,1.5.1.7 ko:K00290,ko:K00293 ko00300,ko00310,ko01100,ko01110,ko01130,ko01230,map00300,map00310,map01100,map01110,map01130,map01230 M00030,M00032 R00715,R02315 RC00215,RC00217,RC00225,RC01532 ko00000,ko00001,ko00002,ko01000 - - - Sacchrp_dh_C,Sacchrp_dh_NADP k59_1521439_2 1121937.AUHJ01000007_gene1846 7.54e-90 273.0 COG2207@1|root,COG2207@2|Bacteria,1RH01@1224|Proteobacteria,1S57M@1236|Gammaproteobacteria,46CNC@72275|Alteromonadaceae 1236|Gammaproteobacteria K Arabinose-binding domain of AraC transcription regulator, N-term oruR - - - - - - - - - - - Arabinose_bd,HTH_18 k59_554220_1 290397.Adeh_3807 1.52e-36 144.0 COG2027@1|root,COG2027@2|Bacteria,1MW40@1224|Proteobacteria,42R96@68525|delta/epsilon subdivisions,2WMVV@28221|Deltaproteobacteria,2YXAR@29|Myxococcales 28221|Deltaproteobacteria M D-alanyl-D-alanine carboxypeptidase dacB - 3.4.16.4 ko:K07259 ko00550,map00550 - - - ko00000,ko00001,ko01000,ko01002,ko01011 - - - Peptidase_S13 k59_1346543_1 1161401.ASJA01000012_gene877 4.87e-17 82.0 COG3182@1|root,COG3182@2|Bacteria,1MVET@1224|Proteobacteria,2U200@28211|Alphaproteobacteria,43WK3@69657|Hyphomonadaceae 28211|Alphaproteobacteria S PepSY-associated TM region - - - - - - - - - - - - PepSY_TM k59_617362_1 404589.Anae109_1359 2.28e-48 163.0 COG1830@1|root,COG1830@2|Bacteria,1MW9N@1224|Proteobacteria,42PEB@68525|delta/epsilon subdivisions,2WM0Y@28221|Deltaproteobacteria,2Z349@29|Myxococcales 28221|Deltaproteobacteria G DeoC/LacD family aldolase fbaB - 4.1.2.13 ko:K11645 ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00003 R01068,R01070,R01829,R02568 RC00438,RC00439,RC00603,RC00604 ko00000,ko00001,ko00002,ko01000 - - - DeoC k59_617362_2 1128111.HMPREF0870_00548 4.94e-42 144.0 COG0698@1|root,COG0698@2|Bacteria,1V3HE@1239|Firmicutes,4H4IP@909932|Negativicutes 909932|Negativicutes G isomerase B rpiB - 5.3.1.6 ko:K01808 ko00030,ko00051,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00051,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01056,R09030 RC00376,RC00434 ko00000,ko00001,ko00002,ko01000 - - - LacAB_rpiB k59_1290431_1 1122137.AQXF01000002_gene360 3.73e-150 456.0 COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,2TS2I@28211|Alphaproteobacteria 28211|Alphaproteobacteria F Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen nrdJ - 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - Ribonuc_red_2_N,Ribonuc_red_lgC k59_780704_1 1007105.PT7_0974 7.56e-20 100.0 COG2114@1|root,COG3629@1|root,COG3899@1|root,COG2114@2|Bacteria,COG3629@2|Bacteria,COG3899@2|Bacteria,1MUDT@1224|Proteobacteria,2VKH1@28216|Betaproteobacteria,3T9M2@506|Alcaligenaceae 28216|Betaproteobacteria K Adenylyl- / guanylyl cyclase, catalytic domain - - - - - - - - - - - - AAA_16,BTAD,Guanylate_cyc,Pkinase,SAM_1 k59_840298_1 323848.Nmul_A1227 1.26e-89 278.0 COG0504@1|root,COG0504@2|Bacteria,1MUIT@1224|Proteobacteria,2VHVA@28216|Betaproteobacteria,372BT@32003|Nitrosomonadales 28216|Betaproteobacteria F Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates pyrG GO:0001775,GO:0002376,GO:0003674,GO:0003824,GO:0003883,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006213,GO:0006220,GO:0006221,GO:0006241,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008283,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009208,GO:0009209,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0015949,GO:0016874,GO:0016879,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0032943,GO:0034404,GO:0034641,GO:0034654,GO:0042098,GO:0042100,GO:0042110,GO:0042113,GO:0042221,GO:0042455,GO:0042493,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045321,GO:0046036,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0046649,GO:0046651,GO:0050896,GO:0055086,GO:0070661,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 6.3.4.2 ko:K01937 ko00240,ko01100,map00240,map01100 M00052 R00571,R00573 RC00010,RC00074 ko00000,ko00001,ko00002,ko01000 - - - CTP_synth_N,GATase k59_219457_1 199310.c4710 2.57e-17 77.8 COG0454@1|root,COG0456@2|Bacteria,1PHCJ@1224|Proteobacteria,1RYNF@1236|Gammaproteobacteria,3XNBF@561|Escherichia 1236|Gammaproteobacteria K Catalyzes the acetylation of dTDP-fucosamine (dTDP-4- amino-4,6-dideoxy-D-galactose) to dTDP-Fuc4NAc, which is utilized in the biosynthesis of the enterobacterial common antigen (ECA) wecD GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0005976,GO:0008080,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009246,GO:0009987,GO:0016051,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044464,GO:0046378,GO:0071704,GO:1901135,GO:1901137,GO:1901576 2.3.1.210 ko:K16704 - - - - ko00000,ko01000 - - iAF1260.b3790,iBWG_1329.BWG_3472,iECBD_1354.ECBD_4249,iECDH10B_1368.ECDH10B_3979,iECDH1ME8569_1439.ECDH1ME8569_3672,iECIAI39_1322.ECIAI39_2997,iECNA114_1301.ECNA114_3928,iEcDH1_1363.EcDH1_4186,iEcolC_1368.EcolC_4213,iJO1366.b3790,iJR904.b3790,iSFV_1184.SFV_3714,iY75_1357.Y75_RS18130 Acetyltransf_1 k59_219457_2 316407.85676259 2.71e-153 433.0 COG1209@1|root,COG1209@2|Bacteria,1MU0X@1224|Proteobacteria,1RMTR@1236|Gammaproteobacteria,3XMX5@561|Escherichia 1236|Gammaproteobacteria M Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis rffH GO:0000271,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0008150,GO:0008152,GO:0008879,GO:0009058,GO:0009059,GO:0009987,GO:0016051,GO:0016740,GO:0016772,GO:0016779,GO:0033692,GO:0034637,GO:0034645,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0045226,GO:0046379,GO:0046872,GO:0071704,GO:1901576 2.7.7.24 ko:K00973 ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130 M00793 R02328 RC00002 ko00000,ko00001,ko00002,ko01000 - - iUMNK88_1353.UMNK88_4598,iYL1228.KPN_04289 NTP_transferase k59_1068241_1 864069.MicloDRAFT_00069730 8.33e-102 308.0 COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,2TSGZ@28211|Alphaproteobacteria,1JUJU@119045|Methylobacteriaceae 28211|Alphaproteobacteria L PFAM transposase IS116 IS110 IS902 family - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_554239_2 1121935.AQXX01000093_gene3417 7.67e-129 374.0 COG0022@1|root,COG0022@2|Bacteria,1R8KB@1224|Proteobacteria,1RP3G@1236|Gammaproteobacteria,1XHJM@135619|Oceanospirillales 135619|Oceanospirillales C Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit bkdA2 - 1.2.4.4 ko:K00167 ko00280,ko00640,ko01100,ko01110,ko01130,map00280,map00640,map01100,map01110,map01130 M00036 R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997 RC00027,RC00627,RC02743,RC02883,RC02949,RC02953 br01601,ko00000,ko00001,ko00002,ko01000 - - - Transket_pyr,Transketolase_C k59_335133_1 66373.JOFQ01000009_gene595 8.32e-05 43.9 COG4319@1|root,COG4319@2|Bacteria,2IIFR@201174|Actinobacteria 201174|Actinobacteria S SnoaL-like domain - - - - - - - - - - - - SnoaL_2 k59_1290446_1 1229909.NSED_02325 1.66e-86 257.0 COG0197@1|root,arCOG04113@2157|Archaea,41SKN@651137|Thaumarchaeota 651137|Thaumarchaeota J ribosomal protein - - - ko:K02866 ko03010,map03010 M00177,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L16 k59_669517_1 575540.Isop_0337 4.01e-49 166.0 COG0299@1|root,COG0299@2|Bacteria,2IZ96@203682|Planctomycetes 203682|Planctomycetes F Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate purN - 2.1.2.2 ko:K11175 ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130 M00048 R04325,R04326 RC00026,RC00197,RC01128 ko00000,ko00001,ko00002,ko01000 - - - Formyl_trans_N k59_1687094_1 627192.SLG_26390 4.92e-45 166.0 COG1629@1|root,COG4206@1|root,COG1629@2|Bacteria,COG4206@2|Bacteria,1QU0Y@1224|Proteobacteria,2TW5W@28211|Alphaproteobacteria,2KEBP@204457|Sphingomonadales 204457|Sphingomonadales HP TonB dependent receptor - - - - - - - - - - - - Plug,TonB_dep_Rec k59_1460110_1 323261.Noc_2786 3.45e-49 167.0 COG1127@1|root,COG1127@2|Bacteria,1MUSD@1224|Proteobacteria,1RMCJ@1236|Gammaproteobacteria,1WW98@135613|Chromatiales 135613|Chromatiales Q PFAM ABC transporter - - - ko:K02065 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - ABC_tran k59_1121071_1 641526.ADIWIN_0337 4.53e-22 95.1 COG0457@1|root,COG0457@2|Bacteria,4NDVW@976|Bacteroidetes,1HXBF@117743|Flavobacteriia 976|Bacteroidetes S Cytochrome C biosynthesis protein - - - - - - - - - - - - TPR_16,TPR_19,TPR_2,TPR_6,TPR_8 k59_1121071_2 504487.JCM19302_4039 6.33e-146 419.0 COG1208@1|root,COG1208@2|Bacteria,4NE97@976|Bacteroidetes,1HYFQ@117743|Flavobacteriia 976|Bacteroidetes JM dTDP-glucose pyrophosphorylase rffH - 2.7.7.24 ko:K00973 ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130 M00793 R02328 RC00002 ko00000,ko00001,ko00002,ko01000 - - - Hexapep,NTP_transferase k59_219468_1 1122137.AQXF01000004_gene1730 5.97e-111 337.0 COG3104@1|root,COG3104@2|Bacteria,1P6K2@1224|Proteobacteria 1224|Proteobacteria E PFAM major facilitator superfamily MFS_1 - - - - - - - - - - - - MFS_1 k59_443217_1 247634.GPB2148_734 3.04e-17 77.8 COG0762@1|root,COG0762@2|Bacteria,1RCZV@1224|Proteobacteria,1S6DW@1236|Gammaproteobacteria,1J6HX@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S integral membrane protein yggT GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K02221 - - - - ko00000,ko02044 - - - YGGT k59_443217_2 76869.PputGB1_5145 5.53e-63 203.0 COG0345@1|root,COG0345@2|Bacteria,1R5J1@1224|Proteobacteria,1RNQK@1236|Gammaproteobacteria,1YUVP@136845|Pseudomonas putida group 1236|Gammaproteobacteria E Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline proC GO:0003674,GO:0003824,GO:0004735,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016491,GO:0016645,GO:0016646,GO:0017144,GO:0018130,GO:0019752,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0055114,GO:0055129,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.5.1.2 ko:K00286 ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230 M00015 R01248,R01251,R03291,R03293 RC00054,RC00083 ko00000,ko00001,ko00002,ko01000 - - iSBO_1134.SBO_0282,ic_1306.c0493 F420_oxidored,P5CR_dimer k59_840312_1 292415.Tbd_0077 5.63e-114 343.0 COG2010@1|root,COG2010@2|Bacteria,1N3PN@1224|Proteobacteria,2VHSF@28216|Betaproteobacteria,1KS6X@119069|Hydrogenophilales 119069|Hydrogenophilales C Cytochrome D1 heme domain - - 1.7.2.1,1.7.99.1 ko:K15864 ko00910,ko01120,map00910,map01120 M00529 R00143,R00783,R00785 RC00086,RC02797 ko00000,ko00001,ko00002,ko01000 - - - Cytochrom_D1,Cytochrome_CBB3 k59_498506_1 1194972.MVAC_19306 3.02e-16 74.7 COG2146@1|root,COG2146@2|Bacteria,2IR4W@201174|Actinobacteria,23ADS@1762|Mycobacteriaceae 201174|Actinobacteria P PFAM Rieske 2Fe-2S nasE - 1.7.1.15 ko:K00363 ko00910,ko01120,map00910,map01120 M00530 R00787 RC00176 ko00000,ko00001,ko00002,ko01000 - - - Rieske,Rieske_2 k59_498506_2 700508.D174_19490 7.9e-38 139.0 COG1680@1|root,COG1680@2|Bacteria,2GJJB@201174|Actinobacteria,232ZY@1762|Mycobacteriaceae 201174|Actinobacteria V beta-lactamase lipP - - - - - - - - - - - Beta-lactamase k59_443230_1 158500.BV97_01240 2.99e-87 270.0 COG0738@1|root,COG0738@2|Bacteria,1MXDC@1224|Proteobacteria,2TSVP@28211|Alphaproteobacteria,2K028@204457|Sphingomonadales 204457|Sphingomonadales G Transporter gluP - - ko:K02429 - - - - ko00000,ko02000 2.A.1.7 - - MFS_1 k59_1796398_1 1134474.O59_002827 7.21e-70 216.0 COG0163@1|root,COG0163@2|Bacteria,1RA0P@1224|Proteobacteria,1RPN1@1236|Gammaproteobacteria,1FFSH@10|Cellvibrio 1236|Gammaproteobacteria H Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN ubiX GO:0003674,GO:0003824,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0008694,GO:0009058,GO:0009108,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901661,GO:1901663 2.5.1.129 ko:K03186 ko00130,ko00627,ko00940,ko01100,ko01110,ko01120,ko01220,map00130,map00627,map00940,map01100,map01110,map01120,map01220 M00117 R01238,R02952,R03367,R04985,R04986,R11225 RC00391,RC00814,RC03392 ko00000,ko00001,ko00002,ko01000 - - - Flavoprotein k59_1409246_2 1122194.AUHU01000007_gene264 2.4e-24 93.2 2E7SV@1|root,33280@2|Bacteria,1NB8Y@1224|Proteobacteria,1SG1J@1236|Gammaproteobacteria,46C6J@72275|Alteromonadaceae 1236|Gammaproteobacteria S PilZ domain - - - - - - - - - - - - PilZ k59_554298_1 935567.JAES01000013_gene811 2.09e-19 90.9 COG0657@1|root,COG0657@2|Bacteria,1R79Q@1224|Proteobacteria,1S1MN@1236|Gammaproteobacteria,1X6G0@135614|Xanthomonadales 135614|Xanthomonadales I alpha/beta hydrolase fold - - - - - - - - - - - - Abhydrolase_3 k59_1235699_1 247634.GPB2148_1837 2.02e-65 226.0 COG4773@1|root,COG4773@2|Bacteria,1NRKQ@1224|Proteobacteria,1SJXP@1236|Gammaproteobacteria 1236|Gammaproteobacteria P TonB dependent receptor - - - - - - - - - - - - Plug,TonB_dep_Rec k59_900570_1 665942.HMPREF1022_01235 5.02e-43 151.0 COG0546@1|root,COG0546@2|Bacteria,1RDDY@1224|Proteobacteria,42USC@68525|delta/epsilon subdivisions,2X5NQ@28221|Deltaproteobacteria,2MGTH@213115|Desulfovibrionales 28221|Deltaproteobacteria S haloacid dehalogenase-like hydrolase - - 3.1.3.18 ko:K01091 ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130 - R01334 RC00017 ko00000,ko00001,ko01000 - - - HAD_2 k59_1744082_1 1122614.JHZF01000011_gene1516 2.34e-52 175.0 COG4974@1|root,COG4974@2|Bacteria,1MVNF@1224|Proteobacteria,2TRAA@28211|Alphaproteobacteria,2PCNY@252301|Oceanicola 28211|Alphaproteobacteria L Phage integrase, N-terminal SAM-like domain xerD - - ko:K04763 - - - - ko00000,ko03036 - - - Phage_int_SAM_1,Phage_integrase k59_1521493_1 436308.Nmar_1358 6.34e-55 189.0 COG0491@1|root,arCOG00507@2157|Archaea 2157|Archaea S Metallo-beta-lactamase superfamily - - - - - - - - - - - - Lactamase_B k59_1521494_1 203122.Sde_0930 2.82e-117 355.0 COG0480@1|root,COG0480@2|Bacteria,1MUCV@1224|Proteobacteria,1RNNJ@1236|Gammaproteobacteria,464WS@72275|Alteromonadaceae 1236|Gammaproteobacteria J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome fusA2 GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2 k59_669546_1 1150469.RSPPHO_02649 2.52e-84 260.0 COG0045@1|root,COG0045@2|Bacteria,1MVCE@1224|Proteobacteria,2TRXK@28211|Alphaproteobacteria,2JPG4@204441|Rhodospirillales 204441|Rhodospirillales C Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit sucC - 6.2.1.5 ko:K01903 ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374,M00620 R00405,R02404 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000 - - - ATP-grasp_2,Ligase_CoA k59_669546_2 269796.Rru_A1212 1.29e-56 183.0 COG0074@1|root,COG0074@2|Bacteria,1MUGA@1224|Proteobacteria,2TQKB@28211|Alphaproteobacteria,2JPJ9@204441|Rhodospirillales 204441|Rhodospirillales C Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit sucD - 6.2.1.5 ko:K01902 ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374,M00620 R00405,R02404 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000 - - - CoA_binding,Ligase_CoA k59_277577_1 1379270.AUXF01000002_gene1717 3.11e-13 75.1 COG5001@1|root,COG5001@2|Bacteria,1ZT12@142182|Gemmatimonadetes 142182|Gemmatimonadetes T Putative diguanylate phosphodiesterase - - - - - - - - - - - - EAL,GGDEF,PAS k59_1579170_1 298386.PBPRA1560 2.47e-23 100.0 COG1566@1|root,COG1566@2|Bacteria,1MWG0@1224|Proteobacteria,1SKG5@1236|Gammaproteobacteria,1XU0T@135623|Vibrionales 135623|Vibrionales V Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - - - - - - - - - - Biotin_lipoyl_2,HlyD_3,HlyD_D23 k59_219527_1 1089552.KI911559_gene1280 1.49e-46 158.0 COG1077@1|root,COG1077@2|Bacteria,1MUMW@1224|Proteobacteria,2TTQ2@28211|Alphaproteobacteria,2JPHS@204441|Rhodospirillales 204441|Rhodospirillales D Rod shape-determining protein MreB mreB - - ko:K03569 - - - - ko00000,ko02048,ko03036,ko04812 1.A.33.1,9.B.157.1 - - MreB_Mbl k59_219527_2 1089552.KI911559_gene1282 1.3e-13 70.5 COG1792@1|root,COG1792@2|Bacteria,1N8ZS@1224|Proteobacteria,2U1FY@28211|Alphaproteobacteria,2JQZK@204441|Rhodospirillales 204441|Rhodospirillales M Involved in formation and maintenance of cell shape mreC - - ko:K03570 - - - - ko00000,ko03036 9.B.157.1 - - MreC k59_1687163_1 46429.BV95_03782 4.34e-12 71.2 COG1629@1|root,COG4771@2|Bacteria,1MWKN@1224|Proteobacteria,2U6BM@28211|Alphaproteobacteria,2KCYH@204457|Sphingomonadales 204457|Sphingomonadales P TonB dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_1235709_1 469383.Cwoe_3223 8.56e-20 84.7 COG0858@1|root,COG0858@2|Bacteria,2HPFC@201174|Actinobacteria,4CQTS@84995|Rubrobacteria 84995|Rubrobacteria J One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA rbfA - - ko:K02834 - - - - ko00000,ko03009 - - - RBFA k59_1235709_2 1122182.KB903839_gene1087 1.03e-42 154.0 COG0618@1|root,COG0618@2|Bacteria,2GN9Z@201174|Actinobacteria,4D9W4@85008|Micromonosporales 201174|Actinobacteria S phosphoesterase RecJ domain protein nrnA GO:0008150,GO:0040007 3.1.13.3,3.1.3.7 ko:K06881 ko00920,ko01100,ko01120,map00920,map01100,map01120 - R00188,R00508 RC00078 ko00000,ko00001,ko01000,ko03400 - - - DHH,DHHA1 k59_162397_1 1121104.AQXH01000001_gene1194 1.81e-113 340.0 COG1012@1|root,COG1012@2|Bacteria,4NEB7@976|Bacteroidetes,1INYZ@117747|Sphingobacteriia 976|Bacteroidetes C Belongs to the aldehyde dehydrogenase family aldB - 1.2.1.3 ko:K00128,ko:K00138 ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130 M00135 R00264,R00631,R00710,R00711,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146 RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_392419_1 903818.KI912268_gene3152 1.18e-61 203.0 COG1459@1|root,COG1459@2|Bacteria,3Y48Z@57723|Acidobacteria 57723|Acidobacteria NU Type II secretion system (T2SS), protein F - - - ko:K02455 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - T2SSF k59_1346628_1 1168034.FH5T_18310 5.74e-44 154.0 COG0508@1|root,COG0508@2|Bacteria,4NKFG@976|Bacteroidetes 976|Bacteroidetes C COGs COG0508 Pyruvate 2-oxoglutarate dehydrogenase complex dihydrolipoamide acyltransferase (E2) protein - - 2.3.1.12 ko:K00627 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200 M00307 R00209,R02569 RC00004,RC02742,RC02857 br01601,ko00000,ko00001,ko00002,ko01000 - - - 2-oxoacid_dh k59_1068289_1 316407.85674876 1.69e-121 373.0 COG3468@1|root,COG3468@2|Bacteria,1R3VW@1224|Proteobacteria,1RSKC@1236|Gammaproteobacteria 1236|Gammaproteobacteria MU cell adhesion involved in biofilm formation ycgV GO:0007155,GO:0008150,GO:0009987,GO:0022610,GO:0031589,GO:0042710,GO:0043708,GO:0044764,GO:0051704,GO:0090605 - - - - - - - - - - Autotransporter,Pertactin k59_277594_1 1121921.KB898707_gene1181 2.65e-101 317.0 COG0542@1|root,COG0542@2|Bacteria,1MV8B@1224|Proteobacteria,1RMH3@1236|Gammaproteobacteria,2PN35@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria O AAA ATPase domain clpA GO:0000166,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0043335,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0070011,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564 - ko:K03694 - - - - ko00000,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N k59_1290497_1 1266925.JHVX01000001_gene2576 7.02e-17 85.9 COG0642@1|root,COG2205@2|Bacteria,1N17V@1224|Proteobacteria,2WEJE@28216|Betaproteobacteria,372ZN@32003|Nitrosomonadales 28216|Betaproteobacteria T HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain cpxA - 2.7.13.3 ko:K02484,ko:K07640,ko:K07642 ko01503,ko02020,map01503,map02020 M00447,M00450,M00645,M00646,M00648,M00727,M00728 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,HisKA k59_626502_1 134676.ACPL_5090 1.61e-16 77.0 28VK2@1|root,2ZHNE@2|Bacteria,2IBCS@201174|Actinobacteria 201174|Actinobacteria S F420H(2)-dependent quinone reductase - - - - - - - - - - - - F420H2_quin_red k59_344428_1 1163617.SCD_n01834 5.69e-19 85.1 2EIBB@1|root,32XEP@2|Bacteria,1MZDG@1224|Proteobacteria,2VUEA@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_908902_1 323848.Nmul_A0085 4.18e-38 134.0 COG1137@1|root,COG1137@2|Bacteria,1MU8M@1224|Proteobacteria,2VH29@28216|Betaproteobacteria,372DG@32003|Nitrosomonadales 28216|Betaproteobacteria S Branched-chain amino acid ATP-binding cassette transporter lptB - - ko:K06861 ko02010,map02010 M00320 - - ko00000,ko00001,ko00002,ko01000,ko02000 1.B.42.1 - - ABC_tran,BCA_ABC_TP_C k59_908902_2 305700.B447_10977 7.96e-16 79.3 COG1508@1|root,COG1508@2|Bacteria,1MW4V@1224|Proteobacteria,2VIEV@28216|Betaproteobacteria,2KV3Q@206389|Rhodocyclales 206389|Rhodocyclales K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released rpoN1 - - ko:K03092 ko02020,ko05111,map02020,map05111 - - - ko00000,ko00001,ko03021 - - - Sigma54_AID,Sigma54_CBD,Sigma54_DBD k59_1248091_1 1215114.BBIU01000029_gene3443 1e-74 234.0 COG0564@1|root,COG0564@2|Bacteria,1MUBN@1224|Proteobacteria,1RN7F@1236|Gammaproteobacteria 1236|Gammaproteobacteria J Responsible for synthesis of pseudouridine from uracil rluD GO:0000027,GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022607,GO:0022613,GO:0022618,GO:0031118,GO:0034470,GO:0034622,GO:0034641,GO:0034660,GO:0042254,GO:0042255,GO:0042273,GO:0043170,GO:0043412,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:1901360 5.4.99.23 ko:K06180 - - - - ko00000,ko01000,ko03009 - - iE2348C_1286.E2348C_2868,iECED1_1282.ECED1_3035,iECSF_1327.ECSF_2432 PseudoU_synth_2,S4 k59_118315_1 526222.Desal_2833 3.52e-64 201.0 COG2818@1|root,COG2818@2|Bacteria,1R9X5@1224|Proteobacteria,42QWV@68525|delta/epsilon subdivisions,2WMPT@28221|Deltaproteobacteria,2MB6B@213115|Desulfovibrionales 28221|Deltaproteobacteria L PFAM Methyladenine glycosylase tag - 3.2.2.20 ko:K01246 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - Adenine_glyco k59_965522_1 1400525.JNIU01000001_gene1129 4.3e-30 121.0 COG3046@1|root,COG3046@2|Bacteria,1MUHX@1224|Proteobacteria,2TQP6@28211|Alphaproteobacteria,4BP8J@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria S PFAM FAD binding domain of DNA photolyase phrB GO:0000166,GO:0000719,GO:0003674,GO:0003824,GO:0003913,GO:0003914,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006290,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016829,GO:0016830,GO:0033554,GO:0034641,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0050896,GO:0051536,GO:0051539,GO:0051540,GO:0051716,GO:0071704,GO:0071949,GO:0090304,GO:0097159,GO:0140097,GO:1901265,GO:1901360,GO:1901363 - ko:K06876 - - - - ko00000 - - - DPRP,FAD_binding_7 k59_908908_1 1415778.JQMM01000001_gene1702 7.61e-31 121.0 COG0354@1|root,COG0354@2|Bacteria,1N852@1224|Proteobacteria,1RPWB@1236|Gammaproteobacteria,1J62T@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S aminomethyltransferase related to GcvT ygfZ GO:0003674,GO:0005488,GO:0005542,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006790,GO:0008144,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0016226,GO:0019842,GO:0022607,GO:0031163,GO:0031406,GO:0033218,GO:0036094,GO:0043167,GO:0043168,GO:0043177,GO:0044085,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0051186,GO:0071840,GO:0072341,GO:0097159,GO:1901363 - ko:K06980 - - - - ko00000,ko03016 - - - GCV_T,GCV_T_C k59_5259_1 590998.Celf_1553 0.00095 47.4 COG0697@1|root,COG0697@2|Bacteria,2GK49@201174|Actinobacteria 201174|Actinobacteria EG of the drug metabolite transporter (DMT) superfamily cyeA - - - - - - - - - - - EamA k59_570118_1 425104.Ssed_4047 3.97e-29 121.0 COG0243@1|root,COG0243@2|Bacteria,1P01N@1224|Proteobacteria,1SYHR@1236|Gammaproteobacteria,2Q985@267890|Shewanellaceae 1236|Gammaproteobacteria C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family phsA - 1.8.5.5 ko:K08352 ko00920,ko01120,map00920,map01120 - R10149 RC02823 ko00000,ko00001,ko01000,ko02000 5.A.3.5 - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding,TAT_signal k59_1361115_1 258594.RPA2515 9.23e-105 315.0 COG1509@1|root,COG1509@2|Bacteria,1MUPJ@1224|Proteobacteria,2TT31@28211|Alphaproteobacteria,3JQS7@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria E Lysine-2,3-aminomutase kamA - 5.4.3.2 ko:K01843 ko00310,map00310 - R00461 RC00303 ko00000,ko00001,ko01000 - - - Fer4_12,Fer4_14,LAM_C,Radical_SAM k59_1022550_1 1500890.JQNL01000001_gene2973 9.19e-71 219.0 COG0655@1|root,COG0655@2|Bacteria,1MW7N@1224|Proteobacteria,1S23B@1236|Gammaproteobacteria,1X4PZ@135614|Xanthomonadales 135614|Xanthomonadales S Belongs to the WrbA family wrbA - 1.6.5.2 ko:K03809 ko00130,ko01110,map00130,map01110 - R02964,R03643,R03816 RC00819 ko00000,ko00001,ko01000 - - - FMN_red k59_400697_1 1122137.AQXF01000002_gene291 1.91e-75 238.0 COG1520@1|root,COG1520@2|Bacteria,1MXIJ@1224|Proteobacteria,2TUAD@28211|Alphaproteobacteria 28211|Alphaproteobacteria S COG1520 FOG WD40-like repeat bamB - - ko:K17713 - - - - ko00000,ko02000 1.B.33.1 - - PQQ_2,PQQ_3 k59_400697_2 1122137.AQXF01000002_gene290 1.12e-86 269.0 COG1160@1|root,COG1160@2|Bacteria,1MU9S@1224|Proteobacteria,2TT38@28211|Alphaproteobacteria 28211|Alphaproteobacteria S GTPase that plays an essential role in the late steps of ribosome biogenesis der - - ko:K03977 - - - - ko00000,ko03009 - - - KH_dom-like,MMR_HSR1 k59_1699993_1 1229909.NSED_03110 3.25e-107 321.0 arCOG01390@1|root,arCOG01390@2157|Archaea,41S7Q@651137|Thaumarchaeota 651137|Thaumarchaeota M Glycosyl transferase family 21 - - - - - - - - - - - - Glycos_transf_2 k59_513509_1 1232683.ADIMK_0084 1.22e-101 316.0 COG0471@1|root,COG0471@2|Bacteria,1MU0K@1224|Proteobacteria,1RMI1@1236|Gammaproteobacteria,464A6@72275|Alteromonadaceae 1236|Gammaproteobacteria P COG0471 Di- and tricarboxylate transporters - - - - - - - - - - - - CitMHS,TrkA_C k59_513509_2 642492.Clole_2034 1.24e-06 52.8 COG0659@1|root,COG0659@2|Bacteria,1TPI4@1239|Firmicutes,24978@186801|Clostridia 186801|Clostridia P Sulfate transporter - - - ko:K03321 - - - - ko00000,ko02000 2.A.53.3 - - STAS,Sulfate_transp k59_626530_1 1552758.NC00_06165 0.000237 47.0 COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,1RN9T@1236|Gammaproteobacteria,1X4A0@135614|Xanthomonadales 135614|Xanthomonadales M Belongs to the peptidase S1C family mucD - 3.4.21.107 ko:K04771 ko01503,ko02020,map01503,map02020 M00728 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 - - - PDZ_2,Trypsin_2 k59_1135057_1 215803.DB30_0296 3.58e-06 48.5 COG0649@1|root,COG0649@2|Bacteria,1MVIN@1224|Proteobacteria,42M9G@68525|delta/epsilon subdivisions,2WIS7@28221|Deltaproteobacteria,2YU4Q@29|Myxococcales 28221|Deltaproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoD GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0016020,GO:0044424,GO:0044464,GO:0071944 1.6.5.3 ko:K00333,ko:K13378 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_30kDa,Complex1_49kDa k59_1304620_1 1343740.M271_50545 6.04e-08 58.5 COG1309@1|root,COG1309@2|Bacteria,2GMNZ@201174|Actinobacteria 201174|Actinobacteria K transcriptional regulator - - - - - - - - - - - - TetR_N k59_1304620_3 1254432.SCE1572_09995 3.15e-78 275.0 COG0515@1|root,COG0642@1|root,COG2203@1|root,COG3899@1|root,COG0515@2|Bacteria,COG2203@2|Bacteria,COG2205@2|Bacteria,COG3899@2|Bacteria,1RAUK@1224|Proteobacteria,43AZ0@68525|delta/epsilon subdivisions,2X6D9@28221|Deltaproteobacteria,2Z3AH@29|Myxococcales 1224|Proteobacteria KLT GAF domain - - - - - - - - - - - - AAA_16,GAF,GAF_3,HATPase_c,HisKA,PAS_4,Pkinase k59_683017_1 522306.CAP2UW1_1371 1.87e-74 232.0 COG0123@1|root,COG0123@2|Bacteria,1MU7P@1224|Proteobacteria,2VIK8@28216|Betaproteobacteria,1KPT8@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria BQ Chromatin structure and dynamics Secondary metabolites biosynthesis, transport, and catabolism hdaH - - - - - - - - - - - Hist_deacetyl k59_1304640_1 1459636.NTE_02626 8.98e-51 172.0 COG2141@1|root,arCOG02410@2157|Archaea 2157|Archaea C COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - - - - - - - - - - Bac_luciferase k59_231162_1 1122137.AQXF01000004_gene1651 2.57e-95 289.0 COG2081@1|root,COG2081@2|Bacteria,1MUGC@1224|Proteobacteria,2TTXA@28211|Alphaproteobacteria 28211|Alphaproteobacteria S flavoproteins yhiN GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - ko:K07007 - - - - ko00000 - - - HI0933_like k59_1530531_1 946077.W5A_11349 4.4e-115 340.0 COG0766@1|root,COG0766@2|Bacteria,4NDV8@976|Bacteroidetes,1HWNU@117743|Flavobacteriia 976|Bacteroidetes M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine murA - 2.5.1.7 ko:K00790 ko00520,ko00550,ko01100,map00520,map00550,map01100 - R00660 RC00350 ko00000,ko00001,ko01000,ko01011 - - - EPSP_synthase k59_1586858_2 1379698.RBG1_1C00001G1008 3.86e-150 433.0 COG0205@1|root,COG0205@2|Bacteria,2NNY2@2323|unclassified Bacteria 2|Bacteria G Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis pfkA - 2.7.1.11,2.7.1.90 ko:K00850,ko:K21071 ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230 M00001,M00345 R00756,R00764,R02073,R03236,R03237,R03238,R03239,R04779 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000,ko01009,ko03019 - - - PFK k59_1022577_1 378806.STAUR_8390 2.34e-44 164.0 COG0612@1|root,COG0612@2|Bacteria,1MVST@1224|Proteobacteria,42NYP@68525|delta/epsilon subdivisions,2WIPJ@28221|Deltaproteobacteria,2YWH3@29|Myxococcales 28221|Deltaproteobacteria S Insulinase (Peptidase family M16) - - - ko:K07263 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M16,Peptidase_M16_C k59_740028_1 693272.E3T587_CROVB 4.93e-16 83.6 4QB5I@10239|Viruses,4QUT2@35237|dsDNA viruses no RNA stage 10239|Viruses S N-methyltransferase activity - - - - - - - - - - - - - k59_231170_1 1123514.KB905899_gene1780 3.54e-39 143.0 COG3111@1|root,COG3111@2|Bacteria,1MU8B@1224|Proteobacteria,1S1UJ@1236|Gammaproteobacteria,460U6@72273|Thiotrichales 72273|Thiotrichales S short chain amide porin - - - - - - - - - - - - - k59_1586859_1 1197477.IA57_05680 9.51e-54 173.0 COG1435@1|root,COG1435@2|Bacteria,4NE5R@976|Bacteroidetes,1HY1G@117743|Flavobacteriia 976|Bacteroidetes F thymidine kinase tdk GO:0003674,GO:0003824,GO:0004797,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006213,GO:0006259,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009120,GO:0009123,GO:0009124,GO:0009157,GO:0009162,GO:0009165,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0018130,GO:0019136,GO:0019205,GO:0019206,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046104,GO:0046125,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0090304,GO:0090407,GO:1901135,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901576,GO:1901657 2.7.1.21 ko:K00857 ko00240,ko00983,ko01100,map00240,map00983,map01100 - R01567,R02099,R08233 RC00002,RC00017 ko00000,ko00001,ko01000 - - - TK k59_1586859_2 886377.Murru_1249 1.01e-66 214.0 COG0787@1|root,COG0787@2|Bacteria,4NEXM@976|Bacteroidetes,1HWKS@117743|Flavobacteriia 976|Bacteroidetes M Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids alr - 5.1.1.1,6.3.2.10 ko:K01775,ko:K01929 ko00300,ko00473,ko00550,ko01100,ko01502,map00300,map00473,map00550,map01100,map01502 - R00401,R04573,R04617 RC00064,RC00141,RC00285 ko00000,ko00001,ko01000,ko01011 - - - Ala_racemase_C,Ala_racemase_N,Mur_ligase,Mur_ligase_M k59_62049_1 1097668.BYI23_A000030 8.09e-167 490.0 COG0187@1|root,COG0187@2|Bacteria,1MVKT@1224|Proteobacteria,2VI8N@28216|Betaproteobacteria,1K194@119060|Burkholderiaceae 28216|Betaproteobacteria L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrB - 5.99.1.3 ko:K02470 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim k59_1700039_1 436308.Nmar_0650 7.11e-27 105.0 COG0388@1|root,arCOG00062@2157|Archaea 2157|Archaea H Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase - - 3.5.1.3 ko:K13566 ko00250,map00250 - R00269,R00348 RC00010 ko00000,ko00001,ko01000 - - - CN_hydrolase k59_1700039_2 1229909.NSED_07005 1.37e-45 151.0 arCOG08684@1|root,arCOG08684@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_1700039_3 1229909.NSED_03355 7.53e-86 280.0 COG1196@1|root,arCOG00371@2157|Archaea,41SDS@651137|Thaumarchaeota 651137|Thaumarchaeota D SMC proteins Flexible Hinge Domain - - - ko:K03529 - - - - ko00000,ko03036 - - - SMC_N,SMC_hinge k59_288010_1 1096930.L284_15190 3.09e-108 335.0 COG4581@1|root,COG4581@2|Bacteria,1MVD6@1224|Proteobacteria,2TR7N@28211|Alphaproteobacteria,2JZXM@204457|Sphingomonadales 204457|Sphingomonadales L helicase - - 3.6.4.13 ko:K17675 - - - - ko00000,ko01000,ko03029 - - - Helicase_C k59_1191773_1 1049564.TevJSym_bu00010 9.65e-147 431.0 COG0480@1|root,COG0480@2|Bacteria,1MUCV@1224|Proteobacteria,1RNSZ@1236|Gammaproteobacteria,1J4UF@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome fusA - - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2 k59_1643728_1 439235.Dalk_0752 1.12e-34 127.0 COG2834@1|root,COG2834@2|Bacteria,1MXW0@1224|Proteobacteria,42QPE@68525|delta/epsilon subdivisions,2WN39@28221|Deltaproteobacteria,2MJHS@213118|Desulfobacterales 28221|Deltaproteobacteria M Protein of unknown function (DUF1329) - - - - - - - - - - - - LolA_like k59_1643728_2 414684.RC1_2375 3.03e-30 110.0 COG2967@1|root,COG2967@2|Bacteria,1MZ2Z@1224|Proteobacteria,2U9JM@28211|Alphaproteobacteria,2JSX8@204441|Rhodospirillales 204441|Rhodospirillales P protein affecting Mg2 Co2 transport apaG - - ko:K06195 - - - - ko00000 - - - DUF525 k59_1191775_1 29908.U7PRB7 1.95e-06 54.7 COG3119@1|root,KOG3867@2759|Eukaryota,38I60@33154|Opisthokonta,3P0W3@4751|Fungi,3QP3Z@4890|Ascomycota,2162V@147550|Sordariomycetes,3URRZ@5151|Ophiostomatales 4751|Fungi P Sulfatase - - 3.10.1.1 ko:K01565 ko00531,ko01100,ko04142,map00531,map01100,map04142 M00078 R07814 - ko00000,ko00001,ko00002,ko01000 - - - DUF4976,Sulfatase k59_344495_1 1229909.NSED_02880 2.53e-93 281.0 arCOG14332@1|root,arCOG14332@2157|Archaea 1229909.NSED_02880|- - - - - - - - - - - - - - - - k59_513563_1 3702.AT1G62750.1 6.93e-50 179.0 COG0480@1|root,KOG0465@2759|Eukaryota,37K55@33090|Viridiplantae,3G82M@35493|Streptophyta,3HPD8@3699|Brassicales 35493|Streptophyta J Chloroplast-localized elongation factor EF-G involved in protein synthesis in plastids. Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A- site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome - GO:0000166,GO:0003674,GO:0005488,GO:0005524,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0006996,GO:0007275,GO:0008144,GO:0008150,GO:0009507,GO:0009526,GO:0009532,GO:0009536,GO:0009570,GO:0009657,GO:0009658,GO:0009791,GO:0009845,GO:0009941,GO:0009987,GO:0016043,GO:0017076,GO:0030554,GO:0031967,GO:0031975,GO:0032501,GO:0032502,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0048046,GO:0048856,GO:0071840,GO:0090351,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2 k59_5319_1 1349785.BAUG01000023_gene1500 5.81e-110 333.0 COG2759@1|root,COG2759@2|Bacteria,4NG3E@976|Bacteroidetes,1HXR5@117743|Flavobacteriia 976|Bacteroidetes H Belongs to the formate--tetrahydrofolate ligase family fhs GO:0003674,GO:0003824,GO:0004329,GO:0004477,GO:0004488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006144,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009112,GO:0009113,GO:0009256,GO:0009257,GO:0009396,GO:0009987,GO:0016053,GO:0016491,GO:0016645,GO:0016646,GO:0016787,GO:0016810,GO:0016814,GO:0016874,GO:0016879,GO:0018130,GO:0019238,GO:0019438,GO:0019752,GO:0034641,GO:0042398,GO:0042440,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046112,GO:0046148,GO:0046394,GO:0046483,GO:0046653,GO:0046654,GO:0051186,GO:0051188,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:0072522,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.4.3 ko:K01938 ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200 M00140,M00377 R00943 RC00026,RC00111 ko00000,ko00001,ko00002,ko01000 - - - FTHFS k59_400756_1 1134474.O59_003786 2.32e-109 335.0 COG0062@1|root,COG0063@1|root,COG0062@2|Bacteria,COG0063@2|Bacteria,1MU1Q@1224|Proteobacteria,1RMPS@1236|Gammaproteobacteria,1FGMP@10|Cellvibrio 1236|Gammaproteobacteria G Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration nnrD GO:0003674,GO:0003824,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016854,GO:0052855,GO:0052856,GO:0052857 4.2.1.136,5.1.99.6 ko:K17758,ko:K17759 - - - - ko00000,ko01000 - - - Carb_kinase,YjeF_N k59_1304704_1 666685.R2APBS1_1532 6.07e-20 93.2 COG1629@1|root,COG4771@2|Bacteria,1MWKN@1224|Proteobacteria,1RMM6@1236|Gammaproteobacteria,1X2Y6@135614|Xanthomonadales 135614|Xanthomonadales P TonB-dependent Receptor Plug Domain - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_5322_1 1415778.JQMM01000001_gene89 2.82e-55 184.0 COG2269@1|root,COG2269@2|Bacteria,1MU97@1224|Proteobacteria,1RMR9@1236|Gammaproteobacteria,1J5W0@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Elongation factor P--(R)-beta-lysine ligase epmA GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006430,GO:0006464,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016746,GO:0016755,GO:0018193,GO:0018205,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0036211,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0052868,GO:0071704,GO:0071915,GO:0072580,GO:0072581,GO:0090304,GO:0140096,GO:1901360,GO:1901564,GO:1901566,GO:1901576 - ko:K04568 - - - - ko00000,ko01000,ko03012 - - - tRNA-synt_2 k59_570192_1 1168065.DOK_07754 2.4e-98 309.0 COG1060@1|root,COG1060@2|Bacteria,1MX50@1224|Proteobacteria,1RSCG@1236|Gammaproteobacteria,1J4W0@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Elongator protein 3, MiaB family, Radical SAM - - 2.5.1.77 ko:K11779 ko00680,ko01120,map00680,map01120 M00378 R09396 RC01381,RC03002,RC03007 ko00000,ko00001,ko00002,ko01000 - - - CofC,Radical_SAM k59_288037_2 909663.KI867150_gene1155 3.84e-41 148.0 COG1092@1|root,COG1092@2|Bacteria,1MUGB@1224|Proteobacteria,42M7K@68525|delta/epsilon subdivisions,2WKKM@28221|Deltaproteobacteria,2MRBF@213462|Syntrophobacterales 28221|Deltaproteobacteria J S-adenosylmethionine-dependent methyltransferase - - 2.1.1.191 ko:K06969 - - - - ko00000,ko01000,ko03009 - - - Cons_hypoth95,Methyltrans_SAM,Methyltransf_25 k59_683091_2 1279038.KB907341_gene1895 3.19e-90 277.0 COG1683@1|root,COG3272@1|root,COG1683@2|Bacteria,COG3272@2|Bacteria,1MXYZ@1224|Proteobacteria,2UAJA@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Protein of unknown function (DUF1722) - - - - - - - - - - - - DUF1722,DUF523 k59_5337_1 316407.4062589 2.03e-269 754.0 COG0457@1|root,COG0457@2|Bacteria,1RA3P@1224|Proteobacteria,1RY13@1236|Gammaproteobacteria,3XNBM@561|Escherichia 1236|Gammaproteobacteria S Exports the biofilm adhesin polysaccharide poly-beta- 1,6-N-acetyl-D-glucosamine (PGA) across the outer membrane. The PGA transported seems to be partially N-deacetylated since N- deacetylation of PGA by PgaB is needed for PGA export through the PgaA porin pgaA - - ko:K11935 ko02026,map02026 - - - ko00000,ko00001 - - - TPR_16,TPR_19 k59_513581_1 1096930.L284_06165 7.12e-112 340.0 COG0741@1|root,COG0741@2|Bacteria,1MV3F@1224|Proteobacteria,2TRDB@28211|Alphaproteobacteria,2K0PK@204457|Sphingomonadales 204457|Sphingomonadales M COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains) - - - ko:K08309 - - - - ko00000,ko01000,ko01011 - GH23 - SLT k59_1078586_1 296591.Bpro_4849 6.23e-14 77.0 COG2203@1|root,COG3829@1|root,COG2203@2|Bacteria,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria,2WGSI@28216|Betaproteobacteria 28216|Betaproteobacteria K Sigma-54 interaction domain - - - ko:K02584 ko02020,map02020 - - - ko00000,ko00001,ko03000 - - - HTH_8,Sigma54_activat k59_1361221_1 702113.PP1Y_AT19014 1.26e-37 129.0 2E6S2@1|root,331C5@2|Bacteria,1RH06@1224|Proteobacteria,2U98E@28211|Alphaproteobacteria,2K6C3@204457|Sphingomonadales 204457|Sphingomonadales S Signal peptide protein - - - - - - - - - - - - - k59_1361221_2 1096930.L284_14470 2.39e-34 132.0 COG0612@1|root,COG0612@2|Bacteria,1MVST@1224|Proteobacteria,2TRFB@28211|Alphaproteobacteria,2K05M@204457|Sphingomonadales 204457|Sphingomonadales S Peptidase, M16 - - - - - - - - - - - - Peptidase_M16,Peptidase_M16_C k59_457346_1 287986.DV20_00900 7.37e-43 151.0 COG0697@1|root,COG0697@2|Bacteria,2GMPB@201174|Actinobacteria,4DYA1@85010|Pseudonocardiales 201174|Actinobacteria EG EamA-like transporter family - - - ko:K15269 - - - - ko00000,ko02000 2.A.7.3.3 - - EamA k59_1304739_2 1209072.ALBT01000032_gene2044 9.16e-08 51.6 COG2900@1|root,COG2900@2|Bacteria,1NGFM@1224|Proteobacteria,1SGAM@1236|Gammaproteobacteria,1FHP4@10|Cellvibrio 1236|Gammaproteobacteria S SlyX slyX - - ko:K03745 - - - - ko00000 - - - SlyX k59_1304739_3 28229.ND2E_2388 7.01e-114 328.0 COG0450@1|root,COG0450@2|Bacteria,1MWPY@1224|Proteobacteria,1RN4S@1236|Gammaproteobacteria,2Q6F4@267889|Colwelliaceae 1236|Gammaproteobacteria O C-terminal domain of 1-Cys peroxiredoxin tsaA - 1.11.1.15 ko:K03386 ko04214,map04214 - - - ko00000,ko00001,ko01000,ko04147 - - - 1-cysPrx_C,AhpC-TSA k59_570205_1 1122137.AQXF01000004_gene1610 7.38e-167 476.0 COG0452@1|root,COG0452@2|Bacteria,1MVQP@1224|Proteobacteria,2TRN1@28211|Alphaproteobacteria 28211|Alphaproteobacteria H Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine coaBC - 4.1.1.36,6.3.2.5 ko:K13038,ko:K21977 ko00770,ko01100,map00770,map01100 M00120 R03269,R04231 RC00064,RC00090,RC00822 ko00000,ko00001,ko00002,ko01000 - - - DFP,Flavoprotein k59_514655_1 981336.F944_03014 6.94e-36 124.0 COG0292@1|root,COG0292@2|Bacteria,1RGU2@1224|Proteobacteria,1S3P3@1236|Gammaproteobacteria,3NNG8@468|Moraxellaceae 1236|Gammaproteobacteria J Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit rplT GO:0000027,GO:0000900,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006355,GO:0006412,GO:0006417,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015934,GO:0016043,GO:0017148,GO:0019219,GO:0019222,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030371,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0045182,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0051252,GO:0060255,GO:0065003,GO:0065007,GO:0070180,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0080090,GO:0090079,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903506,GO:1990904,GO:2000112,GO:2000113,GO:2001141 - ko:K02887 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L20 k59_514655_2 1122603.ATVI01000005_gene3293 1.95e-13 66.2 COG0291@1|root,COG0291@2|Bacteria,1N6V4@1224|Proteobacteria,1SCHI@1236|Gammaproteobacteria,1X7SV@135614|Xanthomonadales 135614|Xanthomonadales J Belongs to the bacterial ribosomal protein bL35 family rpmI GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - ko:K02916 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L35p k59_910741_1 1528106.JRJE01000004_gene730 6.45e-91 284.0 COG0529@1|root,COG2895@1|root,COG0529@2|Bacteria,COG2895@2|Bacteria,1MUD9@1224|Proteobacteria,2TQNJ@28211|Alphaproteobacteria,2JPGB@204441|Rhodospirillales 204441|Rhodospirillales P Catalyzes the synthesis of activated sulfate cysC - 2.7.1.25,2.7.7.4 ko:K00955 ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130 M00176 R00509,R00529,R04928,R04929 RC00002,RC00078,RC02809,RC02889 ko00000,ko00001,ko00002,ko01000 - - - APS_kinase,GTP_EFTU,GTP_EFTU_D2 k59_910741_2 1122137.AQXF01000001_gene2505 7.08e-197 548.0 COG0175@1|root,COG0175@2|Bacteria,1MUCZ@1224|Proteobacteria,2TT2D@28211|Alphaproteobacteria 28211|Alphaproteobacteria EH sulfate adenylyltransferase subunit 2 cysD - 2.7.7.4 ko:K00957 ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130 M00176,M00596 R00529,R04929 RC02809,RC02889 ko00000,ko00001,ko00002,ko01000 - - - PAPS_reduct k59_1362606_1 313628.LNTAR_00270 2.16e-50 175.0 COG2907@1|root,COG2907@2|Bacteria 2|Bacteria S Flavin containing amine oxidoreductase - - - ko:K06954 - - - - ko00000 - - - Amino_oxidase,NAD_binding_8 k59_1532381_1 1453501.JELR01000002_gene1530 1.22e-105 317.0 COG0001@1|root,COG0001@2|Bacteria,1MUY5@1224|Proteobacteria,1RM7N@1236|Gammaproteobacteria,463YV@72275|Alteromonadaceae 1236|Gammaproteobacteria H Glutamate-1-semialdehyde aminotransferase hemL GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006725,GO:0006778,GO:0006779,GO:0006782,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016853,GO:0016866,GO:0016869,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042286,GO:0042440,GO:0042802,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046483,GO:0046501,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 5.4.3.8 ko:K01845 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R02272 RC00677 ko00000,ko00001,ko00002,ko01000,ko01007 - - iUMNK88_1353.UMNK88_158 Aminotran_3 k59_571365_1 710696.Intca_0709 4.12e-100 313.0 COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,2GKXV@201174|Actinobacteria,4FEQG@85021|Intrasporangiaceae 201174|Actinobacteria C ferredoxin oxidoreductase korA GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0030312,GO:0044464,GO:0050896,GO:0055114,GO:0071944 1.2.7.11,1.2.7.3 ko:K00174 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - PFOR_II,POR,POR_N k59_458615_1 1229909.NSED_00705 3.4e-106 318.0 COG1257@1|root,arCOG04260@2157|Archaea,41SAU@651137|Thaumarchaeota 651137|Thaumarchaeota I Belongs to the HMG-CoA reductase family - - 1.1.1.88 ko:K00054 ko00900,ko01110,ko01130,map00900,map01110,map01130 - R02081 RC00004,RC00644 ko00000,ko00001,ko01000 - - - HMG-CoA_red k59_1024286_1 1122137.AQXF01000002_gene67 7.62e-114 336.0 COG0108@1|root,COG0108@2|Bacteria,1MU8P@1224|Proteobacteria,2TSMA@28211|Alphaproteobacteria 28211|Alphaproteobacteria H Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate ribB - 3.5.4.25,4.1.99.12 ko:K02858,ko:K14652 ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110 M00125,M00840 R00425,R07281 RC00293,RC01792,RC01815,RC02504 ko00000,ko00001,ko00002,ko01000 - - - DHBP_synthase,GTP_cyclohydro2 k59_514676_1 1121918.ARWE01000001_gene2773 4.33e-57 199.0 COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,42MKU@68525|delta/epsilon subdivisions,2WJR3@28221|Deltaproteobacteria,43SBM@69541|Desulfuromonadales 28221|Deltaproteobacteria L UvrD-like helicase C-terminal domain pcrA - 3.6.4.12 ko:K03657 ko03420,ko03430,map03420,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - UvrD-helicase,UvrD_C k59_1079889_1 402881.Plav_1540 3.08e-80 249.0 COG0179@1|root,COG0179@2|Bacteria,1MUPF@1224|Proteobacteria,2TQQG@28211|Alphaproteobacteria,1JNV6@119043|Rhodobiaceae 28211|Alphaproteobacteria Q Fumarylacetoacetate (FAA) hydrolase family - - - - - - - - - - - - DUF2437,FAA_hydrolase k59_1311506_1 247634.GPB2148_2427 9.45e-145 420.0 COG2262@1|root,COG2262@2|Bacteria,1MUA0@1224|Proteobacteria,1RN7V@1236|Gammaproteobacteria,1J4RK@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis hflX GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0003924,GO:0005488,GO:0005524,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006414,GO:0006417,GO:0006464,GO:0006468,GO:0006518,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006996,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010608,GO:0016043,GO:0016310,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0018105,GO:0018193,GO:0018209,GO:0019001,GO:0019222,GO:0019538,GO:0019843,GO:0022411,GO:0030554,GO:0031323,GO:0031326,GO:0032268,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032559,GO:0032561,GO:0032790,GO:0032984,GO:0032988,GO:0034248,GO:0034641,GO:0034645,GO:0035639,GO:0036094,GO:0036211,GO:0036289,GO:0043021,GO:0043022,GO:0043023,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043603,GO:0043604,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0046777,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051246,GO:0060255,GO:0065007,GO:0071704,GO:0071826,GO:0071840,GO:0072344,GO:0080090,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903008,GO:2000112 - ko:K03665 - - - - ko00000,ko03009 - - - GTP-bdg_M,GTP-bdg_N,MMR_HSR1 k59_294877_1 1333507.AUTQ01000152_gene4207 2.78e-153 452.0 COG0296@1|root,COG0296@2|Bacteria,1MVM7@1224|Proteobacteria,1SYH1@1236|Gammaproteobacteria,2Q5EZ@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria G Alpha amylase, C-terminal all-beta domain glgB - 2.4.1.18 ko:K00700 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R02110 - ko00000,ko00001,ko00002,ko01000,ko04147 - CBM48,GH13 - Alpha-amylase,Alpha-amylase_C,CBM_48 k59_689559_1 1125863.JAFN01000001_gene2419 2.12e-67 206.0 COG0852@1|root,COG0852@2|Bacteria,1MX4B@1224|Proteobacteria,42NAR@68525|delta/epsilon subdivisions,2WQB1@28221|Deltaproteobacteria 28221|Deltaproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoC GO:0003674,GO:0003824,GO:0003954,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564 1.6.5.3 ko:K00332 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - iAF987.Gmet_3353 Complex1_30kDa k59_689559_2 1125863.JAFN01000001_gene2418 1.1e-34 127.0 COG0649@1|root,COG0649@2|Bacteria,1MVIN@1224|Proteobacteria,42M9G@68525|delta/epsilon subdivisions,2WIS7@28221|Deltaproteobacteria 28221|Deltaproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoD GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016020,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044464,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0071944,GO:0072521,GO:1901135,GO:1901360,GO:1901564 1.6.5.3 ko:K00333,ko:K13378 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_30kDa,Complex1_49kDa,NiFeSe_Hases k59_1423743_2 1265313.HRUBRA_01329 7.01e-23 97.1 COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,1RQX2@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Fad linked oxidase IV02_25675 - 1.1.3.15 ko:K00104 ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130 - R00475 RC00042 ko00000,ko00001,ko01000 - - - FAD-oxidase_C,FAD_binding_4 k59_407293_1 436308.Nmar_0620 7.75e-74 239.0 COG3356@1|root,arCOG04351@2157|Archaea,41S7S@651137|Thaumarchaeota 651137|Thaumarchaeota S Predicted membrane protein (DUF2070) - - - ko:K08979 - - - - ko00000 - - - DUF2070 k59_1537378_1 794903.OPIT5_05755 1.7e-65 221.0 COG0488@1|root,COG0488@2|Bacteria,46TFE@74201|Verrucomicrobia,3K7RJ@414999|Opitutae 414999|Opitutae S ABC transporter - - - ko:K15738 - - - - ko00000,ko02000 3.A.1.120.6 - - ABC_tran,ABC_tran_CTD,ABC_tran_Xtn k59_1706221_2 305700.B447_06667 2e-56 194.0 COG0154@1|root,COG0154@2|Bacteria,1MUVQ@1224|Proteobacteria,2VK3H@28216|Betaproteobacteria,2KXRD@206389|Rhodocyclales 206389|Rhodocyclales J Amidase - - 3.5.1.54 ko:K01457 ko00220,ko00791,ko01100,ko01120,map00220,map00791,map01100,map01120 - R00005 RC02756 ko00000,ko00001,ko01000 - - - Amidase k59_1762994_1 243231.GSU3460 2.3e-49 169.0 COG1215@1|root,COG2344@1|root,COG1215@2|Bacteria,COG2344@2|Bacteria,1R988@1224|Proteobacteria,42QKI@68525|delta/epsilon subdivisions,2WM6J@28221|Deltaproteobacteria,43S6T@69541|Desulfuromonadales 28221|Deltaproteobacteria M PFAM glycosyl transferase family 2 - - - - - - - - - - - - Glycos_transf_2 k59_1481466_1 1279038.KB907338_gene867 2.59e-26 107.0 COG0704@1|root,COG0704@2|Bacteria,1MUMI@1224|Proteobacteria,2TQMN@28211|Alphaproteobacteria,2JPN3@204441|Rhodospirillales 204441|Rhodospirillales P Plays a role in the regulation of phosphate uptake phoU - - ko:K02039 - - - - ko00000 - - - PhoU k59_633124_1 880071.Fleli_3397 3.38e-32 115.0 COG4327@1|root,COG4327@2|Bacteria,4NSV7@976|Bacteroidetes,47RH4@768503|Cytophagia 976|Bacteroidetes S Domain of unknown function (DUF4212) - - - - - - - - - - - - DUF4212 k59_181400_1 377629.TERTU_1165 1.79e-107 322.0 COG0498@1|root,COG0498@2|Bacteria,1MUWQ@1224|Proteobacteria,1RQ0H@1236|Gammaproteobacteria,2PN9D@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria E Threonine synthase N terminus thrC GO:0003674,GO:0003824,GO:0004795,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006566,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009088,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016838,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.2.3.1 ko:K01733 ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230 M00018 R01466,R05086 RC00017,RC00526 ko00000,ko00001,ko00002,ko01000 - - iLF82_1304.LF82_2261,iNRG857_1313.NRG857_00025 PALP,Thr_synth_N k59_859988_2 436308.Nmar_0299 6.45e-92 283.0 COG0036@1|root,COG3959@1|root,arCOG01053@2157|Archaea,arCOG05046@2157|Archaea,41SBE@651137|Thaumarchaeota 651137|Thaumarchaeota G Transketolase, thiamine diphosphate binding domain - - 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 - - - Ribul_P_3_epim,Transketolase_N k59_1141454_1 1122137.AQXF01000003_gene2271 2.57e-62 204.0 COG3278@1|root,COG3278@2|Bacteria,1MU18@1224|Proteobacteria,2TR2C@28211|Alphaproteobacteria 28211|Alphaproteobacteria C Belongs to the heme-copper respiratory oxidase family ccoN - 1.9.3.1 ko:K00404 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00156 - - ko00000,ko00001,ko00002,ko01000 3.D.4.3 - - COX1 k59_1141454_2 1122137.AQXF01000003_gene2272 4.18e-24 97.1 COG2993@1|root,COG2993@2|Bacteria,1MXEY@1224|Proteobacteria,2TRGW@28211|Alphaproteobacteria 28211|Alphaproteobacteria C COG2993 Cbb3-type cytochrome oxidase, cytochrome c subunit ccoO - - ko:K00405 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00156 - - ko00000,ko00001,ko00002 3.D.4.3 - - FixO k59_351325_1 1134474.O59_001824 1.16e-92 274.0 COG0302@1|root,COG0302@2|Bacteria,1MY3N@1224|Proteobacteria,1RMQM@1236|Gammaproteobacteria,1FG9Z@10|Cellvibrio 1236|Gammaproteobacteria F GTP cyclohydrolase I folE GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003933,GO:0003934,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006066,GO:0006725,GO:0006729,GO:0006732,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009108,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019238,GO:0019438,GO:0019751,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034311,GO:0034312,GO:0034641,GO:0035639,GO:0036094,GO:0042558,GO:0042559,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046146,GO:0046165,GO:0046173,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 3.5.4.16 ko:K01495 ko00790,ko01100,map00790,map01100 M00126,M00841,M00842,M00843 R00428,R04639,R05046,R05048 RC00263,RC00294,RC00323,RC00945,RC01188 ko00000,ko00001,ko00002,ko01000 - - - GTP_cyclohydroI k59_1368158_1 118163.Ple7327_0958 9.44e-16 80.1 COG1136@1|root,COG1136@2|Bacteria,1G1SM@1117|Cyanobacteria 1117|Cyanobacteria V TIGRFAM ABC exporter ATP-binding subunit, DevA family - - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_1593614_1 158500.BV97_02154 1.53e-89 290.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2TQT0@28211|Alphaproteobacteria,2K0BI@204457|Sphingomonadales 204457|Sphingomonadales V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_463712_1 247634.GPB2148_1834 1.1e-85 279.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1J4V8@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K18138 ko01501,ko01503,map01501,map01503 M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000 2.A.6.2 - - ACR_tran k59_1537433_1 1105031.HMPREF1141_2636 1.16e-14 76.3 COG1028@1|root,COG1028@2|Bacteria,1TZY6@1239|Firmicutes,248QZ@186801|Clostridia,36EZZ@31979|Clostridiaceae 186801|Clostridia IQ Dehydrogenase fabG1 - 1.1.1.100 ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short,adh_short_C2 k59_860020_1 1379270.AUXF01000003_gene3772 8.59e-12 70.1 COG1228@1|root,COG1228@2|Bacteria,1ZV1H@142182|Gemmatimonadetes 142182|Gemmatimonadetes Q Amidohydrolase family - - - - - - - - - - - - Amidohydro_1 k59_294915_1 1229909.NSED_00680 2.76e-98 295.0 COG0604@1|root,arCOG01458@2157|Archaea,41SX7@651137|Thaumarchaeota 651137|Thaumarchaeota C Zinc-binding dehydrogenase - - - - - - - - - - - - ADH_N,ADH_zinc_N k59_237422_1 1229909.NSED_00440 2.72e-06 45.4 arCOG11526@1|root,arCOG11526@2157|Archaea,41T9E@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_237422_2 436308.Nmar_0192 2.12e-201 559.0 COG0115@1|root,arCOG02297@2157|Archaea,41SD5@651137|Thaumarchaeota 651137|Thaumarchaeota E Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family - - 2.6.1.42 ko:K00826 ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00036,M00119,M00570 R01090,R01214,R02199,R10991 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_4 k59_576734_1 880072.Desac_1083 2.06e-36 128.0 COG0517@1|root,COG0517@2|Bacteria,1N0EB@1224|Proteobacteria,42W96@68525|delta/epsilon subdivisions,2WRIB@28221|Deltaproteobacteria 28221|Deltaproteobacteria S CBS domain - - - ko:K04767,ko:K07168,ko:K07182 - - - - ko00000 - - - CBS k59_1537438_1 204773.HEAR0358 5.73e-123 380.0 COG3383@1|root,COG3383@2|Bacteria,1QTZB@1224|Proteobacteria,2VP2Q@28216|Betaproteobacteria,472B9@75682|Oxalobacteraceae 28216|Betaproteobacteria C Molybdopterin oxidoreductase Fe4S4 domain fdhA1 - 1.17.1.9,1.17.99.7 ko:K00123,ko:K22015 ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200 - R00519 RC02796 ko00000,ko00001,ko01000 - - - Fer2_4,Fer4,Fer4_9,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3 k59_633166_1 655815.ZPR_3638 3.72e-47 179.0 COG0697@1|root,COG1305@1|root,COG0697@2|Bacteria,COG1305@2|Bacteria,4NF37@976|Bacteroidetes,1IIST@117743|Flavobacteriia 976|Bacteroidetes E Protein of unknown function (DUF2569) - - - - - - - - - - - - DUF2569,DUF3857,Transglut_core k59_125094_1 1229909.NSED_07310 2.1e-81 263.0 COG1205@1|root,arCOG08693@1|root,arCOG00555@2157|Archaea,arCOG08693@2157|Archaea,41SZS@651137|Thaumarchaeota 651137|Thaumarchaeota L DEAD DEAH box helicase - - - ko:K06877 - - - - ko00000 - - - DEAD,DUF1998,Helicase_C k59_463722_1 1094466.KQS_08025 4.48e-15 77.4 COG3279@1|root,COG3279@2|Bacteria,4NFPV@976|Bacteroidetes,1HXX5@117743|Flavobacteriia,2NS90@237|Flavobacterium 976|Bacteroidetes T Two-component system response regulatory protein, LytTR family - - - ko:K02477 - - - - ko00000,ko02022 - - - LytTR,Response_reg k59_407355_1 1122236.KB905141_gene1480 1.86e-45 168.0 COG0658@1|root,COG2333@1|root,COG0658@2|Bacteria,COG2333@2|Bacteria,1MUKF@1224|Proteobacteria,2VHKP@28216|Betaproteobacteria,2KMAI@206350|Nitrosomonadales 206350|Nitrosomonadales S DNA internalization-related competence protein ComEC Rec2 - - - ko:K02238 - M00429 - - ko00000,ko00002,ko02044 3.A.11.1,3.A.11.2 - - Competence,DUF4131,Lactamase_B k59_351363_1 1122137.AQXF01000002_gene183 8.81e-99 300.0 COG0569@1|root,COG0569@2|Bacteria,1MW8R@1224|Proteobacteria,2TRP9@28211|Alphaproteobacteria 28211|Alphaproteobacteria P COG0569 K transport systems, NAD-binding component trkA - - ko:K03499 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - - TrkA_C,TrkA_N k59_803226_1 1144305.PMI02_02833 3.2e-104 331.0 COG1197@1|root,COG1197@2|Bacteria,1MUXG@1224|Proteobacteria,2TR2H@28211|Alphaproteobacteria,2K07V@204457|Sphingomonadales 204457|Sphingomonadales L Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site mfd - - ko:K03723 ko03420,map03420 - - - ko00000,ko00001,ko01000,ko03400 - - - CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF k59_1084972_1 1399115.U719_09600 1.71e-10 62.0 COG4301@1|root,COG4301@2|Bacteria,1V0D3@1239|Firmicutes,4HFAG@91061|Bacilli 91061|Bacilli S Histidine-specific methyltransferase, SAM-dependent - - - - - - - - - - - - Methyltransf_33 k59_1141503_1 1122137.AQXF01000004_gene1854 2.98e-123 376.0 COG0542@1|root,COG0542@2|Bacteria,1MURH@1224|Proteobacteria,2TRKI@28211|Alphaproteobacteria 28211|Alphaproteobacteria O Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE clpB - - ko:K03695 ko04213,map04213 - - - ko00000,ko00001,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N k59_1423796_1 1227349.C170_20765 1.81e-66 221.0 COG0402@1|root,COG0402@2|Bacteria,1VTFK@1239|Firmicutes,4HTWB@91061|Bacilli,26V47@186822|Paenibacillaceae 91061|Bacilli F Amidohydrolase family - - - - - - - - - - - - Amidohydro_1 k59_803239_1 316067.Geob_0107 2.04e-97 286.0 COG2080@1|root,COG2080@2|Bacteria,1MWA6@1224|Proteobacteria,42SKH@68525|delta/epsilon subdivisions,2X60F@28221|Deltaproteobacteria,43UA2@69541|Desulfuromonadales 28221|Deltaproteobacteria C [2Fe-2S] binding domain pcmS - 1.2.5.3 ko:K03518 - - R11168 RC02800 ko00000,ko01000 - - - Fer2,Fer2_2 k59_125109_1 1121912.AUHD01000004_gene2044 1e-102 308.0 COG4124@1|root,COG4124@2|Bacteria,4NEZG@976|Bacteroidetes,1HYFM@117743|Flavobacteriia 976|Bacteroidetes G Belongs to the glycosyl hydrolase 26 family - - 3.2.1.78 ko:K01218,ko:K19355 ko00051,ko02024,map00051,map02024 - R01332 RC00467 ko00000,ko00001,ko01000 - GH26 - Glyco_hydro_26 k59_1423806_1 1380600.AUYN01000002_gene3 3.55e-91 303.0 COG3291@1|root,COG4935@1|root,COG3291@2|Bacteria,COG4935@2|Bacteria,4NDZQ@976|Bacteroidetes,1HX5A@117743|Flavobacteriia 976|Bacteroidetes M C-terminal domain of CHU protein family - - - - - - - - - - - - CHU_C,HYR,SprB k59_803252_1 686340.Metal_3362 0.000104 50.4 COG0760@1|root,COG0760@2|Bacteria,1MWV0@1224|Proteobacteria,1RMT5@1236|Gammaproteobacteria,1XEG5@135618|Methylococcales 135618|Methylococcales O SurA N-terminal domain ppiD - 5.2.1.8 ko:K03770 - - - - ko00000,ko01000,ko03110 - - - Rotamase_2,SurA_N_3 k59_1198209_1 1191523.MROS_0662 9.78e-45 157.0 COG0423@1|root,COG0423@2|Bacteria 2|Bacteria J glycyl-tRNA aminoacylation glyQS GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004812,GO:0004820,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006426,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009345,GO:0009987,GO:0010467,GO:0016070,GO:0016594,GO:0016597,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0031406,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0042165,GO:0042802,GO:0042803,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043177,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046983,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1902494 6.1.1.14 ko:K01880 ko00970,map00970 M00359,M00360 R03654 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - iSB619.SA_RS07880 HGTP_anticodon,tRNA-synt_2b k59_1198209_2 765420.OSCT_1463 8.9e-34 126.0 COG0626@1|root,COG0626@2|Bacteria,2G7Q6@200795|Chloroflexi,3770M@32061|Chloroflexia 32061|Chloroflexia H PFAM Cys Met metabolism pyridoxal-phosphate-dependent - - 4.4.1.11 ko:K01761 ko00270,ko00450,map00270,map00450 - R00654,R04770 RC00196,RC00348,RC01209,RC01210 ko00000,ko00001,ko01000 - - - Cys_Met_Meta_PP k59_1763058_1 330214.NIDE0427 1.9e-64 205.0 COG0616@1|root,COG0616@2|Bacteria,3J0J0@40117|Nitrospirae 40117|Nitrospirae OU Peptidase family S49 - - - ko:K04773 - - - - ko00000,ko01000,ko01002 - - - Peptidase_S49 k59_1763058_2 330214.NIDE0428 3.64e-09 53.5 COG0776@1|root,COG0776@2|Bacteria,3J19J@40117|Nitrospirae 40117|Nitrospirae L bacterial (prokaryotic) histone like domain - - - ko:K05788 - - - - ko00000,ko03032,ko03036,ko03400 - - - Bac_DNA_binding k59_1141539_1 702113.PP1Y_AT9467 2.57e-80 256.0 COG0367@1|root,COG0367@2|Bacteria,1MW4E@1224|Proteobacteria,2TSCY@28211|Alphaproteobacteria,2JZZC@204457|Sphingomonadales 204457|Sphingomonadales E Asparagine synthase - - 6.3.5.4 ko:K01953 ko00250,ko01100,ko01110,map00250,map01100,map01110 - R00578 RC00010 ko00000,ko00001,ko01000,ko01002 - - - Asn_synthase,GATase_7 k59_1141539_2 1088721.NSU_2622 6.72e-07 50.1 COG0540@1|root,COG0540@2|Bacteria,1R3Q5@1224|Proteobacteria,2UE9Y@28211|Alphaproteobacteria 28211|Alphaproteobacteria F Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain - - 2.1.3.2 ko:K00609 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R01397 RC00064,RC02850 ko00000,ko00001,ko00002,ko01000 - - - OTCace,OTCace_N k59_69126_1 1415778.JQMM01000001_gene1825 3.78e-59 196.0 COG2204@1|root,COG2208@1|root,COG2204@2|Bacteria,COG2208@2|Bacteria,1QU7V@1224|Proteobacteria,1T1QA@1236|Gammaproteobacteria,1J52K@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria KT Sigma factor PP2C-like phosphatases - - 3.1.3.3 ko:K07315 - - - - ko00000,ko01000,ko03021 - - - Response_reg,SpoIIE k59_1311618_1 1255043.TVNIR_2802 2.38e-93 280.0 COG0524@1|root,COG0524@2|Bacteria,1QTMS@1224|Proteobacteria,1RQQY@1236|Gammaproteobacteria,1WZWK@135613|Chromatiales 135613|Chromatiales G pfkB family carbohydrate kinase - - 2.7.1.20 ko:K00856 ko00230,ko01100,map00230,map01100 - R00185 RC00002,RC00017 ko00000,ko00001,ko01000 - - - PfkB k59_1425126_1 1122137.AQXF01000006_gene878 1.01e-130 389.0 COG0642@1|root,COG0642@2|Bacteria,1NXDJ@1224|Proteobacteria 1224|Proteobacteria T Histidine kinase - - 2.7.13.3 ko:K07716,ko:K20974 ko02020,ko02025,ko04112,map02020,map02025,map04112 M00511,M00820 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - CHASE,CHASE3,HATPase_c,HisKA,PAS_7,Response_reg k59_1538815_1 555793.WSK_0301 1.47e-12 67.4 COG0457@1|root,COG0457@2|Bacteria,1R6NC@1224|Proteobacteria,2TTYU@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Tetratricopeptide repeat - - - - - - - - - - - - - k59_1538815_2 1122612.AUBA01000020_gene2530 1.33e-33 130.0 COG2244@1|root,COG2244@2|Bacteria,1R9I0@1224|Proteobacteria,2TTBK@28211|Alphaproteobacteria,2KD91@204457|Sphingomonadales 204457|Sphingomonadales S Polysaccharide biosynthesis protein - - - - - - - - - - - - Polysacc_synt_3 k59_1651700_2 1120917.AQXM01000057_gene858 2.12e-69 234.0 COG1875@1|root,COG1875@2|Bacteria,2GK8U@201174|Actinobacteria,1W81D@1268|Micrococcaceae 201174|Actinobacteria T Large family of predicted nucleotide-binding domains phoH2 - - ko:K07175 - - - - ko00000 - - - PIN_4,PhoH k59_747112_1 1229909.NSED_03430 6.15e-134 395.0 COG0155@1|root,arCOG02055@2157|Archaea,41S5Q@651137|Thaumarchaeota 651137|Thaumarchaeota C Sulfite reductase - - 1.8.7.1 ko:K00392 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00176 R00859,R03600 RC00065 ko00000,ko00001,ko00002,ko01000 - - - NIR_SIR,NIR_SIR_ferr k59_1707542_1 1122137.AQXF01000001_gene3279 5.2e-269 757.0 COG0495@1|root,COG0495@2|Bacteria,1MV47@1224|Proteobacteria,2TQPK@28211|Alphaproteobacteria 28211|Alphaproteobacteria J Belongs to the class-I aminoacyl-tRNA synthetase family leuS GO:0003674,GO:0003824,GO:0004812,GO:0004823,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006429,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.4 ko:K01869 ko00970,map00970 M00359,M00360 R03657 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - Anticodon_1,tRNA-synt_1,tRNA-synt_1_2 k59_916934_1 880072.Desac_0098 4.12e-67 219.0 COG1208@1|root,COG1208@2|Bacteria,1MUYJ@1224|Proteobacteria,42MX5@68525|delta/epsilon subdivisions,2X5IB@28221|Deltaproteobacteria 28221|Deltaproteobacteria GJM COGs COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B gamma epsilon subunits (eIF-2Bgamma eIF-2Bepsilon) - - 2.7.7.13,5.4.2.8 ko:K16881 ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130 M00114,M00362 R00885,R01818 RC00002,RC00408 ko00000,ko00001,ko00002,ko01000 - - - Hexapep,NTP_transferase,PGM_PMM_I,PGM_PMM_II k59_70393_1 1121904.ARBP01000039_gene2507 2.7e-100 297.0 COG4221@1|root,COG4221@2|Bacteria,4NGKR@976|Bacteroidetes,47N54@768503|Cytophagia 976|Bacteroidetes S KR domain - - - - - - - - - - - - adh_short k59_238722_1 349124.Hhal_1009 3.25e-78 244.0 COG0772@1|root,COG0772@2|Bacteria,1MUK3@1224|Proteobacteria,1RMEJ@1236|Gammaproteobacteria,1WWAV@135613|Chromatiales 135613|Chromatiales M Peptidoglycan polymerase that is essential for cell wall elongation mrdB - - ko:K05837 - - - - ko00000,ko03036 - - - FTSW_RODA_SPOVE k59_1255854_2 1205680.CAKO01000013_gene86 1.05e-18 84.3 COG0179@1|root,COG0179@2|Bacteria,1R7SI@1224|Proteobacteria,2VFC0@28211|Alphaproteobacteria,2JVWG@204441|Rhodospirillales 204441|Rhodospirillales Q Fumarylacetoacetate (FAA) hydrolase family - - - - - - - - - - - - FAA_hydrolase k59_916939_1 1247726.MIM_c34890 5.56e-06 49.3 COG1028@1|root,COG1028@2|Bacteria,1MWZE@1224|Proteobacteria,2VJFB@28216|Betaproteobacteria,3T3SB@506|Alcaligenaceae 28216|Betaproteobacteria IQ KR domain - - - - - - - - - - - - adh_short_C2 k59_916939_2 1121937.AUHJ01000001_gene749 1.89e-36 136.0 COG2271@1|root,COG2271@2|Bacteria,1QTW2@1224|Proteobacteria,1T3J3@1236|Gammaproteobacteria,469A4@72275|Alteromonadaceae 1236|Gammaproteobacteria G Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 k59_70394_1 592015.HMPREF1705_01136 3.12e-66 214.0 COG1494@1|root,COG1494@2|Bacteria,3T9RI@508458|Synergistetes 508458|Synergistetes G TIGRFAM fructose-1,6-bisphosphatase, class II glpX - 3.1.3.11 ko:K02446 ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200 M00003,M00165,M00167 R00762,R04780 RC00017 ko00000,ko00001,ko00002,ko01000 - - - FBPase_glpX k59_464860_1 926549.KI421517_gene511 1.66e-09 63.9 COG0477@1|root,COG2814@2|Bacteria,4NFRE@976|Bacteroidetes,47N91@768503|Cytophagia 976|Bacteroidetes EGP Transmembrane secretion effector - - - - - - - - - - - - MFS_3 k59_464860_2 1415780.JPOG01000001_gene1900 2.31e-09 58.5 COG2303@1|root,COG2303@2|Bacteria,1MV19@1224|Proteobacteria,1RMD2@1236|Gammaproteobacteria,1X3AK@135614|Xanthomonadales 135614|Xanthomonadales E Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate - - - - - - - - - - - - GMC_oxred_C,GMC_oxred_N k59_1651713_1 1301098.PKB_4478 3.79e-19 91.3 COG2064@1|root,COG2064@2|Bacteria,1RHHS@1224|Proteobacteria,1S61W@1236|Gammaproteobacteria 1236|Gammaproteobacteria NU Type II secretion system (T2SS), protein F - - - ko:K12511 - - - - ko00000,ko02044 - - - T2SSF k59_1651713_2 1123504.JQKD01000016_gene1863 5.38e-15 74.7 COG4965@1|root,COG4965@2|Bacteria,1RDNH@1224|Proteobacteria,2VRA2@28216|Betaproteobacteria,4ADG8@80864|Comamonadaceae 28216|Betaproteobacteria U Type II secretion system tadB - - ko:K12510 - - - - ko00000,ko02044 - - - T2SSF k59_238728_1 323848.Nmul_A1551 3.16e-122 361.0 COG0460@1|root,COG0460@2|Bacteria,1MUDC@1224|Proteobacteria,2VH9T@28216|Betaproteobacteria,372HP@32003|Nitrosomonadales 28216|Betaproteobacteria E homoserine dehydrogenase hom - 1.1.1.3 ko:K00003 ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230 M00017,M00018 R01773,R01775 RC00087 ko00000,ko00001,ko00002,ko01000 - - - ACT,Homoserine_dh,NAD_binding_3 k59_861501_1 1001585.MDS_4770 4.57e-48 166.0 COG1216@1|root,COG1216@2|Bacteria,1RBVM@1224|Proteobacteria,1S2YU@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Glycosyl transferase family 2 - - - - - - - - - - - - Glycos_transf_2 k59_13432_1 596152.DesU5LDRAFT_3045 7.25e-51 177.0 COG0702@1|root,COG0702@2|Bacteria,1PDTN@1224|Proteobacteria,42M8X@68525|delta/epsilon subdivisions,2WJ5J@28221|Deltaproteobacteria,2M7RB@213115|Desulfovibrionales 28221|Deltaproteobacteria GM NAD-dependent epimerase dehydratase - - - - - - - - - - - - DUF2867,NAD_binding_10 k59_1425145_1 1122194.AUHU01000005_gene1119 4.06e-97 292.0 COG0722@1|root,COG0722@2|Bacteria,1MU5Q@1224|Proteobacteria,1RMAA@1236|Gammaproteobacteria,465DU@72275|Alteromonadaceae 1236|Gammaproteobacteria E Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) aroF GO:0003674,GO:0003824,GO:0003849,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0019438,GO:0019752,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.54 ko:K01626 ko00400,ko01100,ko01110,ko01130,ko01230,ko02024,map00400,map01100,map01110,map01130,map01230,map02024 M00022 R01826 RC00435 ko00000,ko00001,ko00002,ko01000 - - iAPECO1_1312.APECO1_3932,iECOK1_1307.ECOK1_2946,iECS88_1305.ECS88_2787,iUMN146_1321.UM146_03705,iUTI89_1310.UTI89_C2934 DAHP_synth_1 k59_238737_1 498211.CJA_2394 3.19e-68 227.0 COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,1RMBS@1236|Gammaproteobacteria,1FG60@10|Cellvibrio 1236|Gammaproteobacteria NU Type II secretion system (T2SS), protein E, N-terminal domain mshE - - ko:K12276 ko05111,map05111 - - - ko00000,ko00001,ko02044 - - - T2SSE,T2SSE_N k59_1142717_1 1122137.AQXF01000002_gene660 9.9e-158 452.0 COG0263@1|root,COG0263@2|Bacteria,1MUBG@1224|Proteobacteria,2TRKB@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate proB - 2.7.2.11 ko:K00931 ko00330,ko00332,ko01100,ko01130,ko01230,map00330,map00332,map01100,map01130,map01230 M00015 R00239 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase,PUA k59_1142717_2 1402135.SUH3_02145 3.65e-26 104.0 COG0345@1|root,COG0345@2|Bacteria,1R5J1@1224|Proteobacteria,2TTY7@28211|Alphaproteobacteria,3ZVHP@60136|Sulfitobacter 28211|Alphaproteobacteria E Pyrroline-5-carboxylate reductase dimerisation proC - 1.5.1.2 ko:K00286 ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230 M00015 R01248,R01251,R03291,R03293 RC00054,RC00083 ko00000,ko00001,ko00002,ko01000 - - - F420_oxidored,P5CR_dimer k59_126408_1 1229909.NSED_00840 4.87e-28 112.0 arCOG10597@1|root,arCOG10597@2157|Archaea 1229909.NSED_00840|- O serine-type endopeptidase activity - - - - - - - - - - - - - k59_1199478_1 448385.sce0293 3.68e-77 241.0 COG1521@1|root,COG1521@2|Bacteria,1MUYA@1224|Proteobacteria,42MVZ@68525|delta/epsilon subdivisions,2WJ3N@28221|Deltaproteobacteria,2YTUR@29|Myxococcales 28221|Deltaproteobacteria F Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis coaX - 2.7.1.33 ko:K03525 ko00770,ko01100,map00770,map01100 M00120 R02971,R03018,R04391 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_1986 Pan_kinase k59_1199478_2 936572.HMPREF1148_0853 0.000108 44.7 COG0340@1|root,COG1654@1|root,COG0340@2|Bacteria,COG1654@2|Bacteria,1TQCU@1239|Firmicutes,4H1W3@909932|Negativicutes 909932|Negativicutes HK Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a repressor birA - 6.3.4.15 ko:K03524 ko00780,ko01100,map00780,map01100 - R01074,R05145 RC00043,RC00070,RC00096,RC02896 ko00000,ko00001,ko01000,ko03000 - - - BPL_C,BPL_LplA_LipB,HTH_11 k59_520923_1 693444.D782_4379 1.56e-136 398.0 COG1171@1|root,COG1171@2|Bacteria,1MVWJ@1224|Proteobacteria,1RMY6@1236|Gammaproteobacteria,282ZA@191675|unclassified Enterobacteriaceae 1236|Gammaproteobacteria E Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA ilvA GO:0003674,GO:0003824,GO:0004794,GO:0005488,GO:0006082,GO:0006520,GO:0006549,GO:0006566,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009081,GO:0009082,GO:0009097,GO:0009987,GO:0016053,GO:0016597,GO:0016829,GO:0016840,GO:0016841,GO:0019752,GO:0019842,GO:0030170,GO:0031406,GO:0036094,GO:0043167,GO:0043168,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.3.1.19 ko:K01754 ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230 M00570 R00220,R00996 RC00418,RC02600 ko00000,ko00001,ko00002,ko01000 - - iAPECO1_1312.APECO1_2699 PALP,Thr_dehydrat_C k59_1764422_1 927677.ALVU02000001_gene3495 3.64e-64 214.0 COG0492@1|root,COG3437@1|root,COG0492@2|Bacteria,COG3437@2|Bacteria,1G082@1117|Cyanobacteria,1H612@1142|Synechocystis 1117|Cyanobacteria O Pyridine nucleotide-disulphide oxidoreductase - - 1.8.1.9 ko:K00384 ko00450,map00450 - R02016,R03596,R09372 RC00013,RC02518,RC02873 ko00000,ko00001,ko01000 - - - Pyr_redox_2 k59_1313014_1 702113.PP1Y_AT7381 3.55e-105 322.0 COG0768@1|root,COG0768@2|Bacteria,1MUNY@1224|Proteobacteria,2TSHQ@28211|Alphaproteobacteria,2K0Y2@204457|Sphingomonadales 204457|Sphingomonadales M Cell division protein FtsI penicillin-binding protein ftsI - 3.4.16.4 ko:K03587 ko00550,ko01501,map00550,map01501 - - - ko00000,ko00001,ko01000,ko01011,ko03036 - - - PBP_dimer,Transpeptidase k59_1764432_2 1144305.PMI02_00387 0.000269 45.4 COG4772@1|root,COG4772@2|Bacteria,1NTC4@1224|Proteobacteria,2U3CZ@28211|Alphaproteobacteria,2K50K@204457|Sphingomonadales 204457|Sphingomonadales P TonB dependent receptor - - - - - - - - - - - - Plug,TonB_dep_Rec k59_474824_1 794903.OPIT5_02770 8.84e-57 185.0 COG0600@1|root,COG0600@2|Bacteria,46XNS@74201|Verrucomicrobia,3K9TQ@414999|Opitutae 414999|Opitutae U Binding-protein-dependent transport system inner membrane component - - - ko:K15577 ko00910,ko02010,map00910,map02010 M00438 - - ko00000,ko00001,ko00002,ko02000 3.A.1.16.1,3.A.1.16.2 - - BPD_transp_1 k59_474824_2 221288.JH992901_gene5041 6.95e-14 72.4 COG0715@1|root,COG1116@1|root,COG0715@2|Bacteria,COG1116@2|Bacteria,1G0A2@1117|Cyanobacteria,1JICQ@1189|Stigonemataceae 1117|Cyanobacteria P NMT1-like family cmpC - - ko:K11952 ko02010,map02010 M00321 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.16.3 - - ABC_tran,NMT1_2 k59_1494195_1 745014.OMB55_00013260 9.4e-45 160.0 COG2271@1|root,COG2271@2|Bacteria,1MWYR@1224|Proteobacteria,1RNBI@1236|Gammaproteobacteria 1236|Gammaproteobacteria G Major facilitator superfamily - - - - - - - - - - - - MFS_1 k59_702431_1 1120953.AUBH01000006_gene2602 1.33e-62 216.0 28HKI@1|root,2Z7VC@2|Bacteria,1MW0I@1224|Proteobacteria,1RQ5H@1236|Gammaproteobacteria,469C8@72275|Alteromonadaceae 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_1494198_1 316067.Geob_3115 1.78e-37 133.0 COG2095@1|root,COG2095@2|Bacteria,1N689@1224|Proteobacteria,42UPI@68525|delta/epsilon subdivisions,2WNQP@28221|Deltaproteobacteria 28221|Deltaproteobacteria U UPF0056 inner membrane protein - - - ko:K05595 - - - - ko00000,ko02000 2.A.95.1 - - MarC k59_1550544_1 1122604.JONR01000018_gene1064 7.26e-39 150.0 COG1716@1|root,COG1716@2|Bacteria,1R72N@1224|Proteobacteria,1S5IZ@1236|Gammaproteobacteria,1X6SR@135614|Xanthomonadales 135614|Xanthomonadales T Cytochrome c3 - - - - - - - - - - - - - k59_1096668_1 1278073.MYSTI_07387 6.95e-59 197.0 COG0624@1|root,COG0624@2|Bacteria,1MVBR@1224|Proteobacteria,42MY5@68525|delta/epsilon subdivisions,2WKST@28221|Deltaproteobacteria,2YUHP@29|Myxococcales 28221|Deltaproteobacteria E succinyl-diaminopimelate desuccinylase dapE2 - 3.5.1.18 ko:K01439 ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230 M00016 R02734 RC00064,RC00090 ko00000,ko00001,ko00002,ko01000 - - - M20_dimer,Peptidase_M20,Peptidase_M28 k59_1719413_1 1437824.BN940_07671 7.37e-24 106.0 COG2936@1|root,COG2936@2|Bacteria,1MVA8@1224|Proteobacteria,2VTNQ@28216|Betaproteobacteria,3T83X@506|Alcaligenaceae 28216|Betaproteobacteria S X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain - - - ko:K06978 - - - - ko00000 - - - PepX_C,Peptidase_S15 k59_1719413_2 1079460.ATTQ01000018_gene4560 2.95e-47 162.0 COG1309@1|root,COG1309@2|Bacteria,1NDME@1224|Proteobacteria,2U7ZS@28211|Alphaproteobacteria,4BBQC@82115|Rhizobiaceae 28211|Alphaproteobacteria K Domain of unknown function (DUF1956) - - - - - - - - - - - - DUF1956,TetR_N k59_1719413_3 1079460.ATTQ01000018_gene4559 2.33e-17 84.0 COG0845@1|root,COG0845@2|Bacteria,1MUG6@1224|Proteobacteria,2TTRG@28211|Alphaproteobacteria,4BARW@82115|Rhizobiaceae 28211|Alphaproteobacteria M secretion protein - - - ko:K01993 - - - - ko00000 - - - Biotin_lipoyl_2,HlyD_3,HlyD_D23 k59_589216_1 1386089.N865_08345 5.15e-10 64.7 COG2186@1|root,COG2186@2|Bacteria,2I90D@201174|Actinobacteria,4FIP5@85021|Intrasporangiaceae 201174|Actinobacteria K FCD - - - - - - - - - - - - FCD,GntR k59_1719416_1 998674.ATTE01000001_gene1669 1.43e-41 155.0 COG1806@1|root,COG1806@2|Bacteria,1MUHU@1224|Proteobacteria,1RPHX@1236|Gammaproteobacteria,460FM@72273|Thiotrichales 72273|Thiotrichales S Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the phosphoenolpyruvate synthase (PEPS) by catalyzing its phosphorylation dephosphorylation - - 2.7.11.33,2.7.4.28 ko:K09773 - - - - ko00000,ko01000 - - - Kinase-PPPase k59_1662324_1 247634.GPB2148_78 2.41e-56 191.0 COG3653@1|root,COG3653@2|Bacteria,1MWWY@1224|Proteobacteria 1224|Proteobacteria Q COG3653 N-acyl-D-aspartate D-glutamate deacylase dan - 3.5.1.81 ko:K06015 - - R02192 RC00064,RC00328 ko00000,ko01000 - - - Amidohydro_3 k59_1662324_2 1122599.AUGR01000004_gene2211 5.63e-44 155.0 COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,1RNAM@1236|Gammaproteobacteria,1XI60@135619|Oceanospirillales 135619|Oceanospirillales G Permease - - - - - - - - - - - - DctM k59_137658_1 472759.Nhal_0193 2.36e-40 159.0 COG2133@1|root,COG2133@2|Bacteria,1MV2E@1224|Proteobacteria,1RNGN@1236|Gammaproteobacteria,1WXFQ@135613|Chromatiales 135613|Chromatiales G PFAM Glucose Sorbosone dehydrogenase - - - ko:K21430 - - - - ko00000,ko01000 - - - GSDH k59_1042647_1 713587.THITH_00660 0.000112 49.7 COG0457@1|root,COG2304@1|root,COG0457@2|Bacteria,COG2304@2|Bacteria 2|Bacteria IU oxidoreductase activity - - - - - - - - - - - - CHU_C,TSP_3 k59_1435218_1 351348.Maqu_0609 1.65e-102 308.0 COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,1MW8A@1224|Proteobacteria,1RRNV@1236|Gammaproteobacteria,46D6X@72275|Alteromonadaceae 1236|Gammaproteobacteria L DDE superfamily endonuclease - - - - - - - - - - - - DDE_3,HTH_28,HTH_29,HTH_32,HTH_33 k59_307694_2 1144305.PMI02_00078 6.85e-156 447.0 COG1104@1|root,COG1104@2|Bacteria,1MU1C@1224|Proteobacteria,2TSQE@28211|Alphaproteobacteria,2K05P@204457|Sphingomonadales 204457|Sphingomonadales E overlaps another CDS with the same product name - - 2.8.1.7 ko:K04487 ko00730,ko01100,ko04122,map00730,map01100,map04122 - R07460,R11528,R11529 RC01789,RC02313 ko00000,ko00001,ko01000,ko02048,ko03016,ko03029 - - - Aminotran_5 k59_1154908_1 1144305.PMI02_04013 2.76e-152 443.0 COG1053@1|root,COG1053@2|Bacteria,1MU5M@1224|Proteobacteria,2TQJA@28211|Alphaproteobacteria,2K1NE@204457|Sphingomonadales 204457|Sphingomonadales C Belongs to the FAD-dependent oxidoreductase 2 family. FRD SDH subfamily sdhA - 1.3.5.1,1.3.5.4 ko:K00239 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134 M00009,M00011,M00149,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,Succ_DH_flav_C k59_1608250_2 1123257.AUFV01000001_gene1467 2.49e-12 67.0 COG1721@1|root,COG1721@2|Bacteria,1R3QD@1224|Proteobacteria,1S5F7@1236|Gammaproteobacteria,1X33K@135614|Xanthomonadales 135614|Xanthomonadales S conserved protein (some members contain a von Willebrand factor type A (vWA) domain) - - - - - - - - - - - - DUF58 k59_1382448_1 95619.PM1_0208030 1.31e-52 175.0 COG4660@1|root,COG4660@2|Bacteria,1MW6N@1224|Proteobacteria,1RMEH@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Part of a membrane complex involved in electron transport rnfE GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008152,GO:0016020,GO:0016021,GO:0016491,GO:0016651,GO:0031224,GO:0044425,GO:0044464,GO:0055114,GO:0071944 - ko:K03613 - - - - ko00000 - - - Rnf-Nqr k59_928138_1 998674.ATTE01000001_gene2426 8.9e-100 301.0 COG0012@1|root,COG0012@2|Bacteria,1MVM4@1224|Proteobacteria,1RMBI@1236|Gammaproteobacteria,45ZRA@72273|Thiotrichales 72273|Thiotrichales J ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner ychF - - ko:K06942 - - - - ko00000,ko03009 - - - MMR_HSR1,YchF-GTPase_C k59_251438_1 426716.JOAJ01000008_gene4698 9.34e-16 82.8 COG2141@1|root,COG2141@2|Bacteria,2HVKH@201174|Actinobacteria,4FVVG@85025|Nocardiaceae 201174|Actinobacteria C Luciferase-like monooxygenase - - - - - - - - - - - - Bac_luciferase k59_1382453_1 1296416.JACB01000015_gene4657 9.12e-07 57.8 COG2972@1|root,COG2972@2|Bacteria,4NF45@976|Bacteroidetes,1HXAW@117743|Flavobacteriia,2YHT3@290174|Aquimarina 976|Bacteroidetes T Histidine kinase - - - - - - - - - - - - His_kinase,TPR_12,TPR_7,TPR_8 k59_590717_2 477184.KYC_12193 1.99e-48 166.0 COG1804@1|root,COG1804@2|Bacteria,1NSWZ@1224|Proteobacteria 1224|Proteobacteria C Dehydratase - - 2.8.3.15 ko:K07544 ko00623,ko01100,ko01120,ko01220,map00623,map01100,map01120,map01220 M00418 R05588 RC00014,RC00137 ko00000,ko00001,ko00002,ko01000 - - - CoA_transf_3 k59_1212421_2 2340.JV46_04290 3.24e-28 115.0 COG1999@1|root,COG4531@1|root,COG1999@2|Bacteria,COG4531@2|Bacteria,1RHJ8@1224|Proteobacteria,1SYEA@1236|Gammaproteobacteria,1J6I1@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P protein SCO1 SenC PrrC, involved in biogenesis of respiratory and photosynthetic systems - - - ko:K07152 - - - - ko00000,ko03029 - - - SCO1-SenC,ZnuA k59_1663515_1 436308.Nmar_0684 7.18e-56 183.0 COG1163@1|root,arCOG00358@2157|Archaea,41SAD@651137|Thaumarchaeota 651137|Thaumarchaeota S small GTP-binding protein - - - ko:K06944 - - - - ko00000 - - - MMR_HSR1,MMR_HSR1_Xtn,TGS k59_874379_1 349124.Hhal_0149 3.53e-49 172.0 28I8B@1|root,2Z8B5@2|Bacteria,1MUNM@1224|Proteobacteria,1RQ1H@1236|Gammaproteobacteria,1WXBU@135613|Chromatiales 135613|Chromatiales P Cytochrome c bacterial - - - - - - - - - - - - Cytochrome_C554,Cytochrome_cB k59_874379_2 1163617.SCD_n01150 2.07e-07 50.8 COG4117@1|root,COG4117@2|Bacteria,1R5GN@1224|Proteobacteria,2VP9C@28216|Betaproteobacteria 28216|Betaproteobacteria C cytochrome - - - - - - - - - - - - Ni_hydr_CYTB k59_1495825_1 1197477.IA57_11055 5.69e-106 317.0 COG0399@1|root,COG0399@2|Bacteria,4NG9W@976|Bacteroidetes,1HZDU@117743|Flavobacteriia 976|Bacteroidetes E Belongs to the DegT DnrJ EryC1 family - - 2.6.1.109 ko:K19715 - - R11395 RC00160 ko00000,ko01000,ko01005 - - - DegT_DnrJ_EryC1 k59_366037_1 1122929.KB908216_gene2003 1.19e-16 87.0 COG3182@1|root,COG3182@2|Bacteria,1MX8C@1224|Proteobacteria,2TSQ9@28211|Alphaproteobacteria 28211|Alphaproteobacteria S iron-regulated membrane protein - - - - - - - - - - - - PepSY,PepSY_TM k59_366037_2 398579.Spea_4007 2.82e-34 129.0 COG1999@1|root,COG1999@2|Bacteria,1RHSV@1224|Proteobacteria,1S6HW@1236|Gammaproteobacteria,2QBR2@267890|Shewanellaceae 1236|Gammaproteobacteria S Electron transport protein SCO1 SenC scoP - - ko:K07152 - - - - ko00000,ko03029 - - - SCO1-SenC k59_309225_1 1216976.AX27061_3721 2.97e-29 119.0 COG0559@1|root,COG0559@2|Bacteria,1N54M@1224|Proteobacteria,2VKEA@28216|Betaproteobacteria,3T3EP@506|Alcaligenaceae 28216|Betaproteobacteria U Belongs to the binding-protein-dependent transport system permease family - - - ko:K01997 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - BPD_transp_2 k59_475948_1 391589.RGAI101_4073 5.46e-50 172.0 COG1236@1|root,COG1236@2|Bacteria,1MUDD@1224|Proteobacteria,2TVFM@28211|Alphaproteobacteria 28211|Alphaproteobacteria J exonuclease of the beta-lactamase fold involved in RNA processing - - - ko:K07576 - - - - ko00000 - - - Beta-Casp,Lactamase_B,Lactamase_B_2,RMMBL k59_475948_2 1122137.AQXF01000004_gene1656 2.65e-49 171.0 COG0213@1|root,COG0213@2|Bacteria,1MV3H@1224|Proteobacteria,2TS24@28211|Alphaproteobacteria 28211|Alphaproteobacteria F The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis - GO:0003674,GO:0003824,GO:0004645,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016740,GO:0016757,GO:0016758,GO:0044424,GO:0044444,GO:0044464 2.4.2.4 ko:K00758 ko00240,ko00983,ko01100,ko05219,map00240,map00983,map01100,map05219 - R01570,R02484,R08222,R08230 RC00063 ko00000,ko00001,ko01000 - - - Glycos_trans_3N,Glycos_transf_3,PYNP_C k59_1720997_1 661478.OP10G_1168 2.92e-13 75.1 COG3170@1|root,COG4447@1|root,COG3170@2|Bacteria,COG4447@2|Bacteria 2|Bacteria S cellulose binding - - - - - - - - - - - - Peptidase_S8,Sortilin-Vps10 k59_1774764_1 511680.BUTYVIB_02044 8.69e-61 197.0 COG1134@1|root,COG1134@2|Bacteria,1TQKK@1239|Firmicutes,24A5V@186801|Clostridia,4BZAK@830|Butyrivibrio 186801|Clostridia GM ATPases associated with a variety of cellular activities - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_704014_1 857087.Metme_2701 4.5e-19 91.7 COG1858@1|root,COG1858@2|Bacteria,1RC4D@1224|Proteobacteria,1SJKT@1236|Gammaproteobacteria,1XFYK@135618|Methylococcales 135618|Methylococcales C cytochrome C peroxidase - - - - - - - - - - - - - k59_704014_2 1123251.ATWM01000005_gene1527 0.000352 47.8 COG0454@1|root,COG0456@2|Bacteria,2HXZN@201174|Actinobacteria,4FIVZ@85021|Intrasporangiaceae 201174|Actinobacteria K FR47-like protein - - - - - - - - - - - - Acetyltransf_1 k59_139189_1 1150469.RSPPHO_01240 2.12e-25 95.5 COG1841@1|root,COG1841@2|Bacteria,1PU2S@1224|Proteobacteria,2UF55@28211|Alphaproteobacteria,2JTU5@204441|Rhodospirillales 204441|Rhodospirillales J Ribosomal protein L30 rpmD - - ko:K02907 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L30 k59_139189_2 1122137.AQXF01000006_gene957 5.81e-81 242.0 COG0200@1|root,COG0200@2|Bacteria,1RDC8@1224|Proteobacteria,2U79D@28211|Alphaproteobacteria 28211|Alphaproteobacteria J binds to the 23S rRNA rplO GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - ko:K02876 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L27A k59_139189_3 1122137.AQXF01000006_gene956 1.16e-61 201.0 COG0201@1|root,COG0201@2|Bacteria,1MVU7@1224|Proteobacteria,2TQMT@28211|Alphaproteobacteria 28211|Alphaproteobacteria U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently secY - - ko:K03076 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5 - - SecY k59_194251_1 754477.Q7C_1175 1.84e-26 110.0 COG0768@1|root,COG0768@2|Bacteria,1MV8C@1224|Proteobacteria,1RN9H@1236|Gammaproteobacteria,45ZU0@72273|Thiotrichales 72273|Thiotrichales M Catalyzes cross-linking of the peptidoglycan cell wall mrdA - 3.4.16.4 ko:K05515 ko00550,ko01501,map00550,map01501 - - - ko00000,ko00001,ko01000,ko01011 - - - PBP_dimer,Transpeptidase k59_139190_1 1288494.EBAPG3_790 1.74e-41 141.0 COG0233@1|root,COG0233@2|Bacteria,1N66T@1224|Proteobacteria,2VIUA@28216|Betaproteobacteria,3722X@32003|Nitrosomonadales 28216|Betaproteobacteria J Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another frr - - ko:K02838 - - - - ko00000,ko03012 - - - RRF k59_139190_2 1266925.JHVX01000003_gene471 7.36e-47 157.0 COG0020@1|root,COG0020@2|Bacteria,1MVP1@1224|Proteobacteria,2VH2E@28216|Betaproteobacteria,3721N@32003|Nitrosomonadales 28216|Betaproteobacteria H Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids uppS - 2.5.1.31 ko:K00806 ko00900,ko01110,map00900,map01110 - R06447 RC00279,RC02839 ko00000,ko00001,ko01000,ko01006 - - - Prenyltransf k59_194257_1 436308.Nmar_0825 6.08e-108 317.0 COG0330@1|root,arCOG01915@2157|Archaea,41SYP@651137|Thaumarchaeota 651137|Thaumarchaeota O PFAM SPFH domain Band 7 family - - - - - - - - - - - - Band_7 k59_251482_1 459495.SPLC1_S033580 6e-83 264.0 COG2192@1|root,COG2192@2|Bacteria,1G1FV@1117|Cyanobacteria,1H9E9@1150|Oscillatoriales 1117|Cyanobacteria O carbamoyl transferase, NodU family - - - ko:K00612 - - - - ko00000,ko01000 - - - Carbam_trans_C,Carbam_trans_N k59_1097940_1 794903.OPIT5_07745 1.3e-47 169.0 COG2010@1|root,COG2133@1|root,COG2010@2|Bacteria,COG2133@2|Bacteria,46U8H@74201|Verrucomicrobia,3K8WM@414999|Opitutae 414999|Opitutae C Glucose sorbosone dehydrogenase - - - ko:K21430 - - - - ko00000,ko01000 - - - Cytochrome_CBB3,GSDH k59_645601_2 314230.DSM3645_07745 1.28e-94 293.0 COG0388@1|root,COG0454@1|root,COG0388@2|Bacteria,COG0456@2|Bacteria,2IXDC@203682|Planctomycetes 203682|Planctomycetes K COG0454 Histone acetyltransferase HPA2 and related - - - - - - - - - - - - Acetyltransf_1,CN_hydrolase k59_928172_1 1283300.ATXB01000001_gene124 1.47e-71 224.0 COG0672@1|root,COG0672@2|Bacteria,1N48M@1224|Proteobacteria,1S7GF@1236|Gammaproteobacteria 1236|Gammaproteobacteria P )-iron permease - - - ko:K07243 - - - - ko00000,ko02000 2.A.108.1,2.A.108.2 - - FTR1 k59_1212465_1 436308.Nmar_1378 1.49e-116 338.0 COG1409@1|root,arCOG01153@2157|Archaea,41SF2@651137|Thaumarchaeota 651137|Thaumarchaeota S Calcineurin-like phosphoesterase superfamily domain - - - - - - - - - - - - Metallophos k59_26504_1 265072.Mfla_2332 5.02e-36 129.0 COG0336@1|root,COG0336@2|Bacteria,1MUN1@1224|Proteobacteria,2VHPY@28216|Betaproteobacteria,2KKEG@206350|Nitrosomonadales 206350|Nitrosomonadales J Belongs to the RNA methyltransferase TrmD family trmD - 2.1.1.228 ko:K00554 - - R00597 RC00003,RC00334 ko00000,ko01000,ko03016 - - - tRNA_m1G_MT k59_26504_2 1123261.AXDW01000001_gene1363 3.24e-15 72.8 COG0806@1|root,COG0806@2|Bacteria,1MWQR@1224|Proteobacteria,1RNJ2@1236|Gammaproteobacteria,1X63G@135614|Xanthomonadales 135614|Xanthomonadales J An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes rimM - - ko:K02860 - - - - ko00000,ko03009 - - - PRC,RimM k59_1721025_1 1096930.L284_11350 2.01e-116 351.0 COG0370@1|root,COG0370@2|Bacteria,1MUZC@1224|Proteobacteria,2TQSU@28211|Alphaproteobacteria,2K0AQ@204457|Sphingomonadales 204457|Sphingomonadales P Ferrous iron transport protein B feoB - - ko:K04759 - - - - ko00000,ko02000 9.A.8.1 - - FeoB_C,FeoB_N,Gate k59_194264_1 1122137.AQXF01000003_gene2195 2.79e-84 265.0 COG1749@1|root,COG1749@2|Bacteria,1MU5J@1224|Proteobacteria,2TSF2@28211|Alphaproteobacteria 28211|Alphaproteobacteria N Flagellar hook protein flgE flgE - - ko:K02390 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - FlaE,Flg_bb_rod,Flg_bbr_C k59_1495871_1 935567.JAES01000007_gene1860 5.48e-16 82.4 COG5616@1|root,COG5616@2|Bacteria,1NSKC@1224|Proteobacteria,1T49A@1236|Gammaproteobacteria,1XDC3@135614|Xanthomonadales 135614|Xanthomonadales S cAMP biosynthetic process - - - - - - - - - - - - - k59_1721031_1 1007105.PT7_3491 8.85e-13 68.9 COG1028@1|root,COG1028@2|Bacteria,1MUS7@1224|Proteobacteria,2VM6S@28216|Betaproteobacteria,3T1H2@506|Alcaligenaceae 28216|Betaproteobacteria IQ Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) abmB GO:0003674,GO:0003824,GO:0006725,GO:0008150,GO:0008152,GO:0009987,GO:0010130,GO:0016043,GO:0016491,GO:0016614,GO:0016616,GO:0018913,GO:0018915,GO:0022607,GO:0042537,GO:0043933,GO:0044085,GO:0044237,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:1901360 1.1.1.30 ko:K00019,ko:K07535 ko00072,ko00362,ko00650,ko01100,ko01120,ko01220,map00072,map00362,map00650,map01100,map01120,map01220 M00088,M00540 R01361,R05582 RC00117,RC00154 ko00000,ko00001,ko00002,ko01000 - - - adh_short,adh_short_C2 k59_475983_1 1205910.B005_2329 2.84e-25 110.0 COG0471@1|root,COG0471@2|Bacteria,2GVHZ@201174|Actinobacteria 201174|Actinobacteria P transporter sdcS - - ko:K14445 - - - - ko00000,ko02000 2.A.47.1 - - Na_sulph_symp k59_194280_1 396588.Tgr7_1535 1.14e-89 286.0 COG0188@1|root,COG0188@2|Bacteria,1MUGG@1224|Proteobacteria,1RN03@1236|Gammaproteobacteria,1WXK8@135613|Chromatiales 135613|Chromatiales L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrA - 5.99.1.3 ko:K02469 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseA_C,DNA_topoisoIV k59_1608339_1 648885.KB316283_gene4381 1.32e-41 148.0 COG0671@1|root,COG0671@2|Bacteria,1RDK3@1224|Proteobacteria,2U7BJ@28211|Alphaproteobacteria,1JTKZ@119045|Methylobacteriaceae 28211|Alphaproteobacteria I PFAM phosphoesterase PA-phosphatase related - - 3.6.1.27 ko:K19302 ko00550,map00550 - R05627 RC00002 ko00000,ko00001,ko01000,ko01011 - - - PAP2 k59_366110_1 436308.Nmar_1467 3.89e-32 119.0 COG1525@1|root,arCOG03192@2157|Archaea 2157|Archaea L COG1525 Micrococcal nuclease (thermonuclease) homologs - - 3.1.31.1 ko:K01174 - - - - ko00000,ko01000 - - - SNase k59_1044223_1 330214.NIDE1300 2.37e-75 227.0 COG0080@1|root,COG0080@2|Bacteria,3J0K2@40117|Nitrospirae 40117|Nitrospirae J Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors rplK - - ko:K02867 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L11,Ribosomal_L11_N k59_1721046_1 426117.M446_0492 4.57e-56 184.0 COG1208@1|root,COG1208@2|Bacteria,1R9ZD@1224|Proteobacteria,2TU2V@28211|Alphaproteobacteria,1JR18@119045|Methylobacteriaceae 28211|Alphaproteobacteria JM PFAM Nucleotidyl transferase MA20_24100 - 2.7.7.13,2.7.7.99 ko:K00966,ko:K00992 ko00051,ko00520,ko01100,ko01110,map00051,map00520,map01100,map01110 M00114,M00361,M00362 R00885,R11025 RC00002 ko00000,ko00001,ko00002,ko01000 - - - NTP_transf_3,NTP_transferase k59_194286_1 1535422.ND16A_1956 2.38e-100 304.0 COG2270@1|root,COG2270@2|Bacteria,1QUVA@1224|Proteobacteria,1T226@1236|Gammaproteobacteria,2Q6F8@267889|Colwelliaceae 1236|Gammaproteobacteria S Acetyl-coenzyme A transporter 1 Z012_03780 - - ko:K08218 ko01501,map01501 M00628 - - ko00000,ko00001,ko00002,ko02000 2.A.1.25 - - MFS_1 k59_1323905_1 1197477.IA57_10755 3.59e-67 216.0 COG0526@1|root,COG0526@2|Bacteria,4NEX3@976|Bacteroidetes,1HY1W@117743|Flavobacteriia 976|Bacteroidetes CO alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen - - - - - - - - - - - - AhpC-TSA,DUF4369,Thioredoxin_8 k59_139240_1 644282.Deba_3132 1.88e-14 72.0 COG0183@1|root,COG0183@2|Bacteria,1MU8C@1224|Proteobacteria,42NW7@68525|delta/epsilon subdivisions,2WKQD@28221|Deltaproteobacteria 28221|Deltaproteobacteria I Belongs to the thiolase family - - 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N k59_139240_2 1380390.JIAT01000012_gene3176 2.49e-09 63.2 COG1545@1|root,COG3425@1|root,COG1545@2|Bacteria,COG3425@2|Bacteria,2GP7R@201174|Actinobacteria,4CTRQ@84995|Rubrobacteria 84995|Rubrobacteria I Rubredoxin-like zinc ribbon domain (DUF35_N) - - - - - - - - - - - - DUF35_N k59_1442487_2 382464.ABSI01000023_gene592 3.08e-35 125.0 COG0840@1|root,COG0840@2|Bacteria 2|Bacteria NT transmembrane signaling receptor activity - - - - - - - - - - - - DUF3365 k59_1614931_1 745718.JADT01000015_gene2831 6.88e-87 257.0 COG1956@1|root,COG1956@2|Bacteria,4NM6D@976|Bacteroidetes,1I19I@117743|Flavobacteriia 976|Bacteroidetes T GAF domain-containing protein msrC - 1.8.4.14 ko:K08968 ko00270,map00270 - R02025 RC00639 ko00000,ko00001,ko01000 - - - GAF,GAF_2 k59_882656_1 396588.Tgr7_3081 2.93e-65 208.0 COG0715@1|root,COG0715@2|Bacteria,1MVJA@1224|Proteobacteria,1RUI0@1236|Gammaproteobacteria,1WXI7@135613|Chromatiales 135613|Chromatiales P NMT1/THI5 like - - - ko:K02051 - M00188 - - ko00000,ko00002,ko02000 3.A.1.16,3.A.1.17 - - NMT1,NMT1_2 k59_1561184_1 391615.ABSJ01000014_gene1623 2.1e-19 85.1 COG0564@1|root,COG0564@2|Bacteria,1MVJ5@1224|Proteobacteria,1RN4N@1236|Gammaproteobacteria,1J5SZ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J COG0564 Pseudouridylate synthases, 23S RNA-specific rluA - 5.4.99.28,5.4.99.29 ko:K06177 - - - - ko00000,ko01000,ko03009,ko03016 - - - PseudoU_synth_2 k59_1561184_2 1429916.X566_16025 9.02e-27 108.0 COG2081@1|root,COG2081@2|Bacteria,1MUGC@1224|Proteobacteria,2TR1K@28211|Alphaproteobacteria,3JSJK@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S HI0933-like protein - - - ko:K07007 - - - - ko00000 - - - HI0933_like k59_203167_1 1278309.KB907111_gene3367 2.06e-89 275.0 COG0172@1|root,COG0172@2|Bacteria,1MUJF@1224|Proteobacteria,1RNAQ@1236|Gammaproteobacteria,1XHWT@135619|Oceanospirillales 135619|Oceanospirillales J Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) serS - 6.1.1.11 ko:K01875 ko00970,map00970 M00359,M00360 R03662,R08218 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Seryl_tRNA_N,tRNA-synt_2b k59_1273602_1 1415778.JQMM01000001_gene196 4.64e-172 485.0 COG1077@1|root,COG1077@2|Bacteria,1MUMW@1224|Proteobacteria,1RN82@1236|Gammaproteobacteria,1J52U@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria D COG1077 Actin-like ATPase involved in cell morphogenesis mreB GO:0000003,GO:0000910,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005856,GO:0005886,GO:0007049,GO:0008150,GO:0008360,GO:0009987,GO:0016020,GO:0019954,GO:0022402,GO:0022414,GO:0022603,GO:0022604,GO:0031224,GO:0031226,GO:0032505,GO:0042802,GO:0043093,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0048519,GO:0048523,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0051301,GO:0051302,GO:0051782,GO:0051983,GO:0065007,GO:0065008,GO:0071944 - ko:K03569 - - - - ko00000,ko02048,ko03036,ko04812 1.A.33.1,9.B.157.1 - - MreB_Mbl k59_935106_1 1122137.AQXF01000006_gene920 1.43e-124 378.0 COG0542@1|root,COG0542@2|Bacteria,1MV8B@1224|Proteobacteria,2TQUZ@28211|Alphaproteobacteria 28211|Alphaproteobacteria O Belongs to the ClpA ClpB family clpA GO:0000166,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0043335,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0070011,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564 - ko:K03694 - - - - ko00000,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N k59_482660_1 396014.BF93_18145 2.8e-30 126.0 COG1316@1|root,COG1316@2|Bacteria,2GM55@201174|Actinobacteria,4FBQW@85020|Dermabacteraceae 201174|Actinobacteria K Cell envelope-related transcriptional attenuator domain - - - - - - - - - - - - LytR_cpsA_psr k59_652736_1 1122137.AQXF01000003_gene2367 2.01e-60 205.0 COG0457@1|root,COG0457@2|Bacteria,1MYB8@1224|Proteobacteria,2TQV5@28211|Alphaproteobacteria 28211|Alphaproteobacteria U COG0457 FOG TPR repeat MA20_42300 - - - - - - - - - - - TPR_16,TPR_19,TPR_2,TPR_6,TPR_7,TPR_8 k59_1104981_1 2074.JNYD01000033_gene6367 4.86e-17 76.3 29JYD@1|root,306VN@2|Bacteria,2GWXT@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - - k59_1220412_1 550540.Fbal_3079 5.51e-85 262.0 COG0126@1|root,COG0126@2|Bacteria,1MUNU@1224|Proteobacteria,1RMUQ@1236|Gammaproteobacteria 1236|Gammaproteobacteria F Belongs to the phosphoglycerate kinase family pgk GO:0003674,GO:0003824,GO:0004618,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016052,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576 2.7.2.3 ko:K00927 ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01512 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000,ko04147 - - iSbBS512_1146.SbBS512_E3351 PGK k59_713499_1 1869.MB27_17200 1.49e-14 77.4 COG1960@1|root,COG1960@2|Bacteria,2GKVN@201174|Actinobacteria,4DD87@85008|Micromonosporales 201174|Actinobacteria I Acyl-CoA dehydrogenase, C-terminal domain fadE33 - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_N k59_319061_2 1121904.ARBP01000005_gene4752 2.07e-08 60.8 COG0642@1|root,COG0642@2|Bacteria,COG2205@2|Bacteria 2|Bacteria T PhoQ Sensor - - - - - - - - - - - - HATPase_c,HisKA,Hpt,PAS_4,Response_reg k59_1392203_1 1517416.IDAT_05320 1.94e-47 164.0 COG0524@1|root,COG0524@2|Bacteria,1MUUC@1224|Proteobacteria,1RMN2@1236|Gammaproteobacteria,2QFPT@267893|Idiomarinaceae 1236|Gammaproteobacteria G Sugar kinase gsk GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008906,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0044237 2.7.1.15,2.7.1.4,2.7.1.73 ko:K00847,ko:K00852,ko:K00892 ko00030,ko00051,ko00230,ko00500,ko00520,ko01100,map00030,map00051,map00230,map00500,map00520,map01100 - R00760,R00867,R01051,R01131,R01228,R02750,R03920 RC00002,RC00017 ko00000,ko00001,ko01000 - - iSDY_1059.SDY_0442 PfkB k59_1392203_2 768671.ThimaDRAFT_1874 2.19e-09 58.9 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1WVZ7@135613|Chromatiales 135613|Chromatiales T Diguanylate cyclase - - - - - - - - - - - - 7TMR-DISMED2,7TMR-DISM_7TM,EAL,GGDEF,PAS_9 k59_1163835_1 1353276.JADR01000002_gene2270 2.36e-94 286.0 COG0165@1|root,COG0165@2|Bacteria,4NFCY@976|Bacteroidetes,1HX0C@117743|Flavobacteriia 976|Bacteroidetes E argininosuccinate lyase argH GO:0003674,GO:0003824,GO:0004056,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016829,GO:0016840,GO:0016842,GO:0019752,GO:0042450,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.3.2.1 ko:K01755 ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230 M00029,M00844,M00845 R01086 RC00445,RC00447 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Lyase_1 k59_652751_1 1318628.MARLIPOL_11990 9.27e-34 124.0 COG1741@1|root,COG1741@2|Bacteria,1MWIP@1224|Proteobacteria,1RS05@1236|Gammaproteobacteria,46682@72275|Alteromonadaceae 1236|Gammaproteobacteria S Belongs to the pirin family - - - ko:K06911 - - - - ko00000 - - - Pirin,Pirin_C k59_652751_2 1127673.GLIP_3589 2.8e-14 68.2 COG0454@1|root,COG0456@2|Bacteria,1RKJA@1224|Proteobacteria,1T1ZP@1236|Gammaproteobacteria,4685F@72275|Alteromonadaceae 1236|Gammaproteobacteria K Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_10 k59_427256_1 159087.Daro_1151 7.46e-165 478.0 COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,2VHQ1@28216|Betaproteobacteria,2KV9Y@206389|Rhodocyclales 206389|Rhodocyclales NU Type II secretion system (T2SS), protein E, N-terminal domain - - - ko:K02454 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - T2SSE,T2SSE_N k59_203194_1 502025.Hoch_2102 2.67e-86 275.0 COG1253@1|root,COG1253@2|Bacteria,1MV3P@1224|Proteobacteria,42N97@68525|delta/epsilon subdivisions,2WNPB@28221|Deltaproteobacteria,2YUUU@29|Myxococcales 28221|Deltaproteobacteria P Transporter associated domain - - - - - - - - - - - - CBS,CorC_HlyC,DUF21 k59_91860_1 1415778.JQMM01000001_gene730 1.41e-72 244.0 COG1391@1|root,COG1391@2|Bacteria,1MU4I@1224|Proteobacteria,1RP9N@1236|Gammaproteobacteria,1J5A6@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell glnE GO:0000166,GO:0000287,GO:0000820,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006521,GO:0006541,GO:0006542,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0008882,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0010565,GO:0016053,GO:0016740,GO:0016772,GO:0016779,GO:0017076,GO:0019222,GO:0019752,GO:0030554,GO:0031323,GO:0032553,GO:0032555,GO:0032559,GO:0033238,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046872,GO:0050789,GO:0050794,GO:0051171,GO:0062012,GO:0065007,GO:0070566,GO:0071704,GO:0080090,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.7.42,2.7.7.89 ko:K00982 - - - - ko00000,ko01000 - - - GlnD_UR_UTase,GlnE k59_319075_1 1229909.NSED_06310 7.65e-85 256.0 COG1407@1|root,arCOG01150@2157|Archaea,41SJB@651137|Thaumarchaeota 651137|Thaumarchaeota S Calcineurin-like phosphoesterase - - - ko:K06953 - - - - ko00000 - - - Metallophos k59_1505259_1 452637.Oter_2162 4.59e-91 276.0 COG1181@1|root,COG1181@2|Bacteria 2|Bacteria F Belongs to the D-alanine--D-alanine ligase family ddlB1 - 6.3.2.4,6.3.5.5 ko:K01921,ko:K01955 ko00240,ko00250,ko00473,ko00550,ko01100,ko01502,map00240,map00250,map00473,map00550,map01100,map01502 M00051 R00256,R00575,R01150,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC00064,RC00141,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000,ko01011 - - - Dala_Dala_lig_C k59_1052425_1 1122137.AQXF01000003_gene1876 9.91e-135 385.0 COG1692@1|root,COG1692@2|Bacteria,1MW12@1224|Proteobacteria,2TS4S@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Protein conserved in bacteria MA20_17970 GO:0003674,GO:0003824,GO:0004112,GO:0004113,GO:0008081,GO:0016787,GO:0016788,GO:0042578 - ko:K09769 - - - - ko00000 - - - YmdB k59_1443503_1 582744.Msip34_2708 2.34e-25 112.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,2VGZ8@28216|Betaproteobacteria 28216|Betaproteobacteria NT chemotaxis - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - 4HB_MCP_1,HAMP,MCPsignal k59_1443503_2 391625.PPSIR1_08396 7.51e-21 96.7 COG3221@1|root,COG3221@2|Bacteria,1MWFF@1224|Proteobacteria,43AKJ@68525|delta/epsilon subdivisions,2WQ9Y@28221|Deltaproteobacteria,2YVPI@29|Myxococcales 28221|Deltaproteobacteria P Bacterial extracellular solute-binding proteins, family 3 - - - ko:K02044 ko02010,map02010 M00223 - - ko00000,ko00001,ko00002,ko02000 3.A.1.9 - - Phosphonate-bd k59_823612_1 1282876.BAOK01000002_gene536 3.84e-197 555.0 COG1960@1|root,COG1960@2|Bacteria,1MU2V@1224|Proteobacteria,2TSK3@28211|Alphaproteobacteria,4BPRD@82117|unclassified Alphaproteobacteria 2|Bacteria I Acyl-CoA dehydrogenase, C-terminal domain - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_203213_1 1122137.AQXF01000006_gene817 2.1e-82 270.0 COG1629@1|root,COG4771@2|Bacteria,1MUWN@1224|Proteobacteria,2TUIR@28211|Alphaproteobacteria 28211|Alphaproteobacteria P COG1629 Outer membrane receptor proteins, mostly Fe transport - - - - - - - - - - - - CarbopepD_reg_2,CarboxypepD_reg,Plug,TonB_dep_Rec k59_765129_1 1229909.NSED_04815 2.54e-09 57.8 COG0745@1|root,arCOG02595@2157|Archaea,41T9R@651137|Thaumarchaeota 651137|Thaumarchaeota T cheY-homologous receiver domain - - - - - - - - - - - - Response_reg k59_1615907_1 402777.KB235904_gene4616 8.79e-37 133.0 COG0098@1|root,COG0098@2|Bacteria,1G1EF@1117|Cyanobacteria,1H7SH@1150|Oscillatoriales 1117|Cyanobacteria J Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body rps5 GO:0003674,GO:0003735,GO:0005198,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0071704,GO:1901564,GO:1901566,GO:1901576 - ko:K02988 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S5,Ribosomal_S5_C k59_260908_1 421052.F945_02618 9.37e-15 80.9 COG2239@1|root,COG2239@2|Bacteria,1MW24@1224|Proteobacteria,1RNE4@1236|Gammaproteobacteria,3NIPA@468|Moraxellaceae 1236|Gammaproteobacteria P Acts as a magnesium transporter mgtE - - ko:K06213 - - - - ko00000,ko02000 1.A.26.1 - - CBS,MgtE,MgtE_N k59_1615908_1 1123261.AXDW01000017_gene3143 2.72e-30 119.0 COG2307@1|root,COG2307@2|Bacteria,1MVZK@1224|Proteobacteria,1RN2Y@1236|Gammaproteobacteria,1X4EN@135614|Xanthomonadales 135614|Xanthomonadales S A predicted alpha-helical domain with a conserved ER motif. - - - - - - - - - - - - Alpha-E k59_823629_1 84531.JMTZ01000010_gene3235 2.25e-27 115.0 COG1020@1|root,COG1020@2|Bacteria,1QK4F@1224|Proteobacteria,1RPAG@1236|Gammaproteobacteria,1X3AB@135614|Xanthomonadales 135614|Xanthomonadales Q non-ribosomal peptide synthetase - - - - - - - - - - - - AMP-binding,AMP-binding_C,Condensation,PP-binding k59_319112_1 1121033.AUCF01000021_gene2886 7.3e-18 89.4 COG0145@1|root,COG0146@1|root,COG0145@2|Bacteria,COG0146@2|Bacteria,1MU2Y@1224|Proteobacteria,2TQZ6@28211|Alphaproteobacteria,2JQPR@204441|Rhodospirillales 204441|Rhodospirillales EQ Hydantoinase/oxoprolinase N-terminal region - - 3.5.2.9 ko:K01469 ko00480,map00480 - R00251 RC00553 ko00000,ko00001,ko01000 - - - Hydant_A_N,Hydantoinase_A,Hydantoinase_B k59_713559_1 345219.Bcoa_2747 1.29e-15 73.6 COG0799@1|root,COG0799@2|Bacteria,1VA2Z@1239|Firmicutes,4HKEJ@91061|Bacilli,1ZGYR@1386|Bacillus 91061|Bacilli J Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation rsfS GO:0003674,GO:0005488,GO:0006417,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0017148,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0034248,GO:0034249,GO:0043021,GO:0043023,GO:0044087,GO:0044877,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0080090,GO:0090069,GO:0090071,GO:2000112,GO:2000113 - ko:K09710 - - - - ko00000,ko03009 - - - RsfS k59_713559_2 572477.Alvin_2147 4.44e-17 82.4 COG1057@1|root,COG1057@2|Bacteria,1RD0J@1224|Proteobacteria,1RP00@1236|Gammaproteobacteria,1WY6R@135613|Chromatiales 135613|Chromatiales H Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) nadD - 2.7.7.18 ko:K00969 ko00760,ko01100,map00760,map01100 M00115 R00137,R03005 RC00002 ko00000,ko00001,ko00002,ko01000 - - - CTP_transf_like k59_375663_3 1123508.JH636442_gene4425 4.36e-33 117.0 2CCFB@1|root,32RVJ@2|Bacteria 2|Bacteria S zinc-finger-containing domain - - - - - - - - - - - - DUF3268 k59_1615917_1 1458427.BAWN01000020_gene1218 4.96e-78 256.0 COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,2VH2F@28216|Betaproteobacteria,4A9Z9@80864|Comamonadaceae 28216|Betaproteobacteria P ATPase, P-type (transporting), HAD superfamily, subfamily IC - - 3.6.3.8 ko:K01537 - - - - ko00000,ko01000 3.A.3.2 - - Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3 k59_146090_1 1121022.ABENE_11250 5.47e-108 322.0 COG2828@1|root,COG2828@2|Bacteria,1MXVV@1224|Proteobacteria,2TQMC@28211|Alphaproteobacteria,2KI6V@204458|Caulobacterales 204458|Caulobacterales S PrpF protein - - 5.3.2.8 ko:K16514 ko00362,ko01120,map00362,map01120 - R07839 RC02426 ko00000,ko00001,ko01000 - - - PrpF k59_91913_1 1117647.M5M_19205 4.61e-110 331.0 COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,1RMBQ@1236|Gammaproteobacteria,1J4DZ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Belongs to the aldehyde dehydrogenase family gabD - 1.2.1.16,1.2.1.20,1.2.1.79 ko:K00135 ko00250,ko00310,ko00350,ko00650,ko00760,ko01100,ko01120,map00250,map00310,map00350,map00650,map00760,map01100,map01120 M00027 R00713,R00714,R02401 RC00080 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_935178_1 1122137.AQXF01000007_gene3478 3.69e-84 256.0 COG3931@1|root,COG3931@2|Bacteria,1QI71@1224|Proteobacteria,2TVK6@28211|Alphaproteobacteria 28211|Alphaproteobacteria E N-formylglutamate amidohydrolase - - - - - - - - - - - - FGase k59_1562645_1 195250.CM001776_gene2695 3.64e-93 280.0 28NY3@1|root,2ZBVC@2|Bacteria,1G5MR@1117|Cyanobacteria 1117|Cyanobacteria - - - - - - - - - - - - - - - k59_36029_1 1122933.JNIY01000009_gene1398 4.4e-05 46.2 COG0711@1|root,COG0711@2|Bacteria,2GNBF@201174|Actinobacteria,4F1F7@85016|Cellulomonadaceae 201174|Actinobacteria C Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) - - - - - - - - - - - - - k59_36029_2 644966.Tmar_0934 1.84e-49 163.0 COG0669@1|root,COG0669@2|Bacteria,1V3MR@1239|Firmicutes,24HC3@186801|Clostridia,3WCIY@538999|Clostridiales incertae sedis 186801|Clostridia H Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate coaD - 2.7.7.3 ko:K00954 ko00770,ko01100,map00770,map01100 M00120 R03035 RC00002 ko00000,ko00001,ko00002,ko01000 - - - CTP_transf_like k59_823681_1 1379698.RBG1_1C00001G0607 2.02e-29 120.0 COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,2NQNE@2323|unclassified Bacteria 2|Bacteria T Serine threonine protein kinase - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - PASTA,Pkinase,TPR_2,TPR_8 k59_884082_1 158500.BV97_03609 7.62e-118 345.0 COG2030@1|root,COG2030@2|Bacteria,1NAYM@1224|Proteobacteria,2TRU0@28211|Alphaproteobacteria,2K3I1@204457|Sphingomonadales 204457|Sphingomonadales I MaoC like domain - - - - - - - - - - - - MaoC_dehydrat_N k59_884082_2 1522072.IL54_4242 7.76e-117 349.0 COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,2TRII@28211|Alphaproteobacteria,2K2B6@204457|Sphingomonadales 204457|Sphingomonadales I AMP-binding enzyme C-terminal domain - - 6.2.1.1,6.2.1.2 ko:K01895,ko:K01896 ko00010,ko00620,ko00640,ko00650,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00650,map00680,map00720,map01100,map01110,map01120,map01130,map01200 M00357 R00235,R00236,R00316,R00926,R01176,R01354 RC00004,RC00012,RC00014,RC00043,RC00070,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000,ko01004 - - - AMP-binding,AMP-binding_C k59_375705_1 231434.JQJH01000002_gene2382 7.93e-13 70.5 COG2844@1|root,COG2844@2|Bacteria,1MV54@1224|Proteobacteria,2TSV0@28211|Alphaproteobacteria,3N9P3@45404|Beijerinckiaceae 28211|Alphaproteobacteria O Metal dependent phosphohydrolases with conserved 'HD' motif. glnD GO:0006355,GO:0006464,GO:0006807,GO:0006808,GO:0007154,GO:0007584,GO:0008150,GO:0008152,GO:0009605,GO:0009719,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0009991,GO:0010033,GO:0010243,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0018175,GO:0018177,GO:0019219,GO:0019222,GO:0019538,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031667,GO:0031668,GO:0031669,GO:0031670,GO:0036211,GO:0042221,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051716,GO:0060255,GO:0065007,GO:0070887,GO:0071310,GO:0071417,GO:0071495,GO:0071496,GO:0071704,GO:0080090,GO:0090293,GO:1901564,GO:1901698,GO:1901699,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141 2.7.7.59 ko:K00990 ko02020,map02020 - - - ko00000,ko00001,ko01000 - - - ACT,GlnD_UR_UTase,GlnE,HD,NTP_transf_2 k59_375705_2 1120956.JHZK01000023_gene1129 4.4e-20 92.4 COG4974@1|root,COG4974@2|Bacteria,1MVNF@1224|Proteobacteria,2TRAA@28211|Alphaproteobacteria,1JN4T@119043|Rhodobiaceae 28211|Alphaproteobacteria L Phage integrase, N-terminal SAM-like domain xerD - - ko:K04763 - - - - ko00000,ko03036 - - - Phage_int_SAM_1,Phage_integrase k59_203278_1 316407.85675242 1.1e-80 244.0 COG1174@1|root,COG1174@2|Bacteria,1MX8D@1224|Proteobacteria,1RSDR@1236|Gammaproteobacteria,3XMU1@561|Escherichia 1236|Gammaproteobacteria P Permease protein yehW GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0015695,GO:0015696,GO:0015697,GO:0015838,GO:0016020,GO:0031460,GO:0044464,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944,GO:0072337 - ko:K05846 ko02010,map02010 M00209 - - ko00000,ko00001,ko00002,ko02000 3.A.1.12 - iEC042_1314.EC042_2361,iECUMN_1333.ECUMN_2462 BPD_transp_1 k59_203278_2 316407.85675241 1.75e-14 65.9 2BT6J@1|root,32NBR@2|Bacteria,1QNAB@1224|Proteobacteria,1TKTR@1236|Gammaproteobacteria,3XRE6@561|Escherichia 1236|Gammaproteobacteria - - yohO - - - - - - - - - - - - k59_765177_1 1437824.BN940_11191 1.37e-11 63.9 COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,2VIAU@28216|Betaproteobacteria,3T2D6@506|Alcaligenaceae 28216|Betaproteobacteria O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner lon - 3.4.21.53 ko:K01338 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - AAA,LON_substr_bdg,Lon_C k59_765177_2 76114.ebA4971 6.51e-49 168.0 COG1219@1|root,COG1219@2|Bacteria,1MVQK@1224|Proteobacteria,2VIEU@28216|Betaproteobacteria,2KVAQ@206389|Rhodocyclales 206389|Rhodocyclales O ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP clpX - - ko:K03544 ko04112,map04112 - - - ko00000,ko00001,ko03110 - - - AAA_2,ClpB_D2-small,zf-C4_ClpX k59_427330_1 240292.Ava_0231 3.73e-67 213.0 COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria 2|Bacteria L Transposase - - - - - - - - - - - - DDE_3,DDE_Tnp_ISAZ013,DUF3105,HTH_28,HTH_33 k59_91951_1 1423144.Gal_01793 3.5e-06 52.8 COG3409@1|root,COG3409@2|Bacteria,1REI1@1224|Proteobacteria 1224|Proteobacteria M Putative peptidoglycan binding domain - - - - - - - - - - - - PG_binding_1 k59_91951_2 243231.GSU3299 1.23e-38 144.0 COG4799@1|root,COG4799@2|Bacteria,1MVAX@1224|Proteobacteria,43AEE@68525|delta/epsilon subdivisions,2WIRF@28221|Deltaproteobacteria,43TAX@69541|Desulfuromonadales 28221|Deltaproteobacteria I Carboxyl transferase domain - - - - - - - - - - - - Carboxyl_trans k59_146129_1 1385519.N801_16560 8.78e-44 151.0 COG2141@1|root,COG2141@2|Bacteria,2GJ6T@201174|Actinobacteria,4FIR9@85021|Intrasporangiaceae 201174|Actinobacteria C Luciferase-like monooxygenase - - - - - - - - - - - - Bac_luciferase k59_427332_1 935848.JAEN01000002_gene751 1.79e-72 230.0 COG1073@1|root,COG1073@2|Bacteria,1MXJ3@1224|Proteobacteria,2TVHP@28211|Alphaproteobacteria,2PYMY@265|Paracoccus 28211|Alphaproteobacteria S Alpha/beta hydrolase of unknown function (DUF1100) - - - - - - - - - - - - Abhydrolase_6,DUF1100,Peptidase_S9 k59_91955_1 1056820.KB900700_gene1124 5.04e-20 86.3 COG0357@1|root,COG0357@2|Bacteria,1MY0K@1224|Proteobacteria,1RMRZ@1236|Gammaproteobacteria,2PNGM@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria M rRNA small subunit methyltransferase G rsmG GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036265,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070043,GO:0070475,GO:0070476,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.170 ko:K03501 - - - - ko00000,ko01000,ko03009,ko03036 - - - GidB k59_36059_1 316407.85676624 2.17e-87 277.0 COG0058@1|root,COG0058@2|Bacteria,1MW4J@1224|Proteobacteria,1RN8P@1236|Gammaproteobacteria,3XMMY@561|Escherichia 1236|Gammaproteobacteria G Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties malP GO:0000272,GO:0003674,GO:0003824,GO:0004645,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0005977,GO:0005980,GO:0006073,GO:0006091,GO:0006112,GO:0008144,GO:0008150,GO:0008152,GO:0008184,GO:0009056,GO:0009057,GO:0009251,GO:0009987,GO:0015980,GO:0016052,GO:0016740,GO:0016757,GO:0016758,GO:0019842,GO:0030170,GO:0030978,GO:0030980,GO:0031220,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044247,GO:0044248,GO:0044260,GO:0044262,GO:0044264,GO:0044275,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0050662,GO:0055114,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901575 2.4.1.1 ko:K00688 ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931 - R02111 - ko00000,ko00001,ko01000 - GT35 iECNA114_1301.ECNA114_3525 Phosphorylase k59_600561_1 935866.JAER01000013_gene1111 8.24e-21 95.1 COG0463@1|root,COG0463@2|Bacteria,2I3C0@201174|Actinobacteria,4DT3N@85009|Propionibacteriales 201174|Actinobacteria M Glycosyl transferase family 2 - - - ko:K20534 - - - - ko00000,ko01000,ko01005,ko02000 4.D.2.1.9 GT2 - Glycos_transf_2 k59_1105089_1 1449351.RISW2_08070 1.95e-74 233.0 COG3677@1|root,COG3677@2|Bacteria,1R999@1224|Proteobacteria,2UD3G@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Transposase and inactivated derivatives - - - - - - - - - - - - DDE_Tnp_IS1595 k59_884111_1 1415778.JQMM01000001_gene919 1.31e-208 587.0 COG1838@1|root,COG1951@1|root,COG1838@2|Bacteria,COG1951@2|Bacteria,1MUV9@1224|Proteobacteria,1RN8U@1236|Gammaproteobacteria,1J4X4@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Catalyzes the reversible hydration of fumarate to (S)- malate fumA GO:0003674,GO:0003824,GO:0004333,GO:0005488,GO:0005515,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016860,GO:0016862,GO:0016999,GO:0017144,GO:0019752,GO:0033554,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0047808,GO:0048037,GO:0050163,GO:0050896,GO:0051536,GO:0051539,GO:0051540,GO:0051716,GO:0055114,GO:0071704,GO:0072350 4.2.1.2 ko:K01676 ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374 R01082 RC00443 ko00000,ko00001,ko00002,ko01000 - - iEC55989_1330.EC55989_1778,iPC815.YPO3335 Fumerase,Fumerase_C k59_1392339_2 1122137.AQXF01000005_gene1279 6.86e-69 234.0 COG2911@1|root,COG2911@2|Bacteria,1MUVD@1224|Proteobacteria,2TR45@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Protein conserved in bacteria tamB - - ko:K09800 - - - - ko00000,ko02000 - - - TamB k59_427337_2 1100720.ALKN01000007_gene2972 1.58e-56 182.0 COG3576@1|root,COG3576@2|Bacteria,1MWG9@1224|Proteobacteria,2VTBU@28216|Betaproteobacteria,4AEGA@80864|Comamonadaceae 28216|Betaproteobacteria S pyridoxamine 5'-phosphate oxidase-related - - - ko:K07006 - - - - ko00000 - - - Putative_PNPOx k59_1505371_1 930169.B5T_01595 4.41e-39 146.0 COG2114@1|root,COG2114@2|Bacteria,1MV1V@1224|Proteobacteria,1RYBQ@1236|Gammaproteobacteria,1XHVD@135619|Oceanospirillales 135619|Oceanospirillales T COG2114 Adenylate cyclase, family 3 (some proteins contain HAMP domain) - - 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 - - - CHASE2,Guanylate_cyc,MASE2 k59_1780820_1 305900.GV64_03470 4.17e-05 45.4 COG0810@1|root,COG0810@2|Bacteria,1MUMT@1224|Proteobacteria,1S3A6@1236|Gammaproteobacteria,1XJV0@135619|Oceanospirillales 135619|Oceanospirillales M Periplasmic protein TonB, links inner and outer membranes tonB - - ko:K03832 - - - - ko00000,ko02000 2.C.1.1 - - TonB_C k59_1780820_2 498211.CJA_0081 6.76e-72 224.0 COG0189@1|root,COG0189@2|Bacteria,1MVUA@1224|Proteobacteria,1RMU0@1236|Gammaproteobacteria,1FG8W@10|Cellvibrio 1236|Gammaproteobacteria H Prokaryotic glutathione synthetase, N-terminal domain gshB GO:0000287,GO:0003674,GO:0003824,GO:0004363,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006518,GO:0006575,GO:0006749,GO:0006750,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0019184,GO:0034641,GO:0042398,GO:0043043,GO:0043167,GO:0043169,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0051186,GO:0051188,GO:0071704,GO:1901564,GO:1901566,GO:1901576 6.3.2.3 ko:K01920 ko00270,ko00480,ko01100,map00270,map00480,map01100 M00118 R00497,R10994 RC00096,RC00141 ko00000,ko00001,ko00002,ko01000 - - iECED1_1282.ECED1_3410,iECP_1309.ECP_2941 GSH-S_ATP,GSH-S_N k59_203311_1 1121875.KB907546_gene2238 3.06e-39 141.0 COG1409@1|root,COG1409@2|Bacteria,4NFAP@976|Bacteroidetes,1I2DE@117743|Flavobacteriia 976|Bacteroidetes S Calcineurin-like phosphoesterase - - - - - - - - - - - - Metallophos,PA14 k59_600575_1 1123487.KB892865_gene1389 2.19e-32 121.0 2DKZ2@1|root,32UFZ@2|Bacteria,1N5GS@1224|Proteobacteria 1224|Proteobacteria S PD-(D/E)XK nuclease superfamily - - - - - - - - - - - - PDDEXK_1 k59_482765_1 1049564.TevJSym_ao00190 7.71e-39 138.0 COG0639@1|root,COG0639@2|Bacteria,1MV10@1224|Proteobacteria,1RPUJ@1236|Gammaproteobacteria,1J5RX@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP apaH GO:0003674,GO:0003824,GO:0004551,GO:0004721,GO:0006139,GO:0006464,GO:0006470,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008138,GO:0008150,GO:0008152,GO:0008796,GO:0008803,GO:0009314,GO:0009628,GO:0009987,GO:0010165,GO:0010212,GO:0015949,GO:0016311,GO:0016462,GO:0016787,GO:0016788,GO:0016791,GO:0016817,GO:0016818,GO:0019538,GO:0034641,GO:0036211,GO:0042578,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044281,GO:0046483,GO:0050896,GO:0055086,GO:0071704,GO:0140096,GO:1901360,GO:1901564 3.6.1.41 ko:K01525 ko00230,map00230 - R00125 RC00002 ko00000,ko00001,ko01000 - - iECIAI39_1322.ECIAI39_0052,iEcSMS35_1347.EcSMS35_0053,iJN746.PP_0399,iSDY_1059.SDY_0074 Metallophos k59_482765_2 1385517.N800_04220 2.02e-53 170.0 COG2967@1|root,COG2967@2|Bacteria,1MZ2Z@1224|Proteobacteria,1S8SE@1236|Gammaproteobacteria,1X6WU@135614|Xanthomonadales 135614|Xanthomonadales P protein affecting Mg2 Co2 transport apaG - - ko:K06195 - - - - ko00000 - - - DUF525 k59_765205_1 234267.Acid_6591 1.29e-74 241.0 COG0591@1|root,COG0591@2|Bacteria,3Y4WN@57723|Acidobacteria 57723|Acidobacteria E Sodium:solute symporter family - - - - - - - - - - - - SSF k59_1105099_1 518766.Rmar_2078 4.79e-59 200.0 COG0471@1|root,COG0471@2|Bacteria,4NFDK@976|Bacteroidetes,1FJTN@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes P Sodium:sulfate symporter transmembrane region - - - ko:K14445 - - - - ko00000,ko02000 2.A.47.1 - - Na_sulph_symp k59_211416_1 742823.HMPREF9465_00485 1.11e-11 69.3 COG4783@1|root,COG4783@2|Bacteria,1MVFV@1224|Proteobacteria,2VHAY@28216|Betaproteobacteria,4PQ8N@995019|Sutterellaceae 28216|Betaproteobacteria S Peptidase family M48 yggG_1 - - - - - - - - - - - Peptidase_M48,TPR_19 k59_722235_1 935863.AWZR01000002_gene1177 1.06e-91 283.0 COG1680@1|root,COG1680@2|Bacteria,1MVPR@1224|Proteobacteria,1S2Q8@1236|Gammaproteobacteria,1XCKK@135614|Xanthomonadales 135614|Xanthomonadales V Beta-lactamase - - - - - - - - - - - - Beta-lactamase k59_546094_1 1260251.SPISAL_01270 2.8e-132 387.0 COG0043@1|root,COG0043@2|Bacteria,1MU62@1224|Proteobacteria,1RNH8@1236|Gammaproteobacteria,1WWBG@135613|Chromatiales 135613|Chromatiales H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol, an intermediate step in ubiquinone biosynthesis ubiD - 4.1.1.98 ko:K03182 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00117 R04985,R04986 RC00391 ko00000,ko00001,ko00002,ko01000 - - - UbiD k59_722242_1 1245471.PCA10_01330 1.8e-50 173.0 COG3239@1|root,COG3239@2|Bacteria,1MXTQ@1224|Proteobacteria,1RRM8@1236|Gammaproteobacteria,1YFKZ@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria I Fatty acid desaturase - - - - - - - - - - - - FA_desaturase k59_943091_2 436308.Nmar_0080 3.83e-123 354.0 COG2082@1|root,arCOG02247@2157|Archaea,41SXG@651137|Thaumarchaeota 651137|Thaumarchaeota H Precorrin-8X methylmutase - - 5.4.99.60,5.4.99.61 ko:K06042 ko00860,ko01100,map00860,map01100 - R05177,R05814 RC01292,RC01980 ko00000,ko00001,ko01000 - - - CbiC k59_1623458_1 394221.Mmar10_2651 9.1e-47 155.0 COG1846@1|root,COG1846@2|Bacteria,1RF8X@1224|Proteobacteria,2U7ND@28211|Alphaproteobacteria,43XV6@69657|Hyphomonadaceae 28211|Alphaproteobacteria K COG1846 Transcriptional regulators - - - - - - - - - - - - MarR k59_1623458_2 1550073.JROH01000016_gene357 7.73e-55 181.0 COG1414@1|root,COG1414@2|Bacteria,1RK6B@1224|Proteobacteria,2UAQS@28211|Alphaproteobacteria,2K51G@204457|Sphingomonadales 204457|Sphingomonadales K Bacterial transcriptional regulator - - - - - - - - - - - - HTH_IclR,IclR k59_943096_1 926569.ANT_11960 2.3e-91 297.0 COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,2G5Y6@200795|Chloroflexi 200795|Chloroflexi H Methionine synthase B12-binding module cap domain protein - - 2.1.1.13,2.1.1.258 ko:K00548,ko:K15023 ko00270,ko00450,ko00670,ko00720,ko01100,ko01110,ko01120,ko01200,ko01230,map00270,map00450,map00670,map00720,map01100,map01110,map01120,map01200,map01230 M00017,M00377 R00946,R02289,R09365,R10243 RC00004,RC00035,RC00113,RC01144,RC01241,RC02871,RC02977 ko00000,ko00001,ko00002,ko01000 - - - B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans k59_999098_1 398527.Bphyt_0513 2.83e-41 146.0 COG0584@1|root,COG0584@2|Bacteria,1MU8H@1224|Proteobacteria,2VKF6@28216|Betaproteobacteria,1K1M5@119060|Burkholderiaceae 28216|Betaproteobacteria C glycerophosphoryl diester phosphodiesterase ugpQ - 3.1.4.46 ko:K01126 ko00564,map00564 - R01030,R01470 RC00017,RC00425 ko00000,ko00001,ko01000 - - - GDPD k59_1172117_1 371731.Rsw2DRAFT_0882 5.4e-55 183.0 COG0777@1|root,COG0777@2|Bacteria,1MW8G@1224|Proteobacteria,2TRSH@28211|Alphaproteobacteria,1FAY6@1060|Rhodobacter 28211|Alphaproteobacteria I Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA accD - 2.1.3.15,6.4.1.2 ko:K01963 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04386 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 - - - Carboxyl_trans k59_1172117_2 717785.HYPMC_0548 4.55e-24 100.0 COG0285@1|root,COG0285@2|Bacteria,1MVCH@1224|Proteobacteria,2TR64@28211|Alphaproteobacteria,3N6CW@45401|Hyphomicrobiaceae 28211|Alphaproteobacteria H Belongs to the folylpolyglutamate synthase family folC - 6.3.2.12,6.3.2.17 ko:K11754 ko00790,ko01100,map00790,map01100 M00126,M00841 R00942,R02237,R04241 RC00064,RC00090,RC00162 ko00000,ko00001,ko00002,ko01000 - - - Mur_ligase_M k59_892170_1 240016.ABIZ01000001_gene5401 8.87e-46 166.0 COG4383@1|root,COG4383@2|Bacteria,46V24@74201|Verrucomicrobia 74201|Verrucomicrobia S Protein of unknown function (DUF935) - - - - - - - - - - - - DUF935 k59_490793_1 867903.ThesuDRAFT_01935 1.38e-64 216.0 COG0171@1|root,COG0388@1|root,COG0171@2|Bacteria,COG0388@2|Bacteria,1TQ38@1239|Firmicutes,2484Z@186801|Clostridia,3WD84@538999|Clostridiales incertae sedis 186801|Clostridia H Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source nadE - 6.3.5.1 ko:K01950 ko00760,ko01100,map00760,map01100 M00115 R00257 RC00010,RC00100 ko00000,ko00001,ko00002,ko01000 - - - CN_hydrolase,NAD_synthase k59_1736212_1 1229909.NSED_07730 4.33e-55 181.0 COG1697@1|root,arCOG04143@2157|Archaea,41SQF@651137|Thaumarchaeota 651137|Thaumarchaeota L Relaxes both positive and negative superturns and exhibits a strong decatenase activity top6A - 5.99.1.3 ko:K03166 - - - - ko00000,ko01000,ko03032 - - - TP6A_N k59_1227996_1 1229909.NSED_07220 6.89e-45 146.0 COG0316@1|root,arCOG04560@2157|Archaea,41SKH@651137|Thaumarchaeota 651137|Thaumarchaeota O Iron-sulfur cluster assembly accessory protein - - - ko:K13628 - - - - ko00000,ko03016 - - - Fe-S_biosyn k59_1227996_2 1229909.NSED_07215 1.7e-45 156.0 COG0358@1|root,arCOG04281@2157|Archaea,41S75@651137|Thaumarchaeota 651137|Thaumarchaeota L DNA primase dnaG - - ko:K02316 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - Toprim_4 k59_383884_2 1229909.NSED_00910 2.04e-52 173.0 COG3794@1|root,arCOG02926@2157|Archaea 1229909.NSED_00910|- C PFAM blue (type 1) copper domain protein - - - - - - - - - - - - - k59_1513396_1 626887.J057_17700 9.51e-46 167.0 COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,1RMZ8@1236|Gammaproteobacteria,46AAE@72275|Alteromonadaceae 1236|Gammaproteobacteria I 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain yfcX - 1.1.1.35,4.2.1.17,5.1.2.3 ko:K01782 ko00071,ko00280,ko00281,ko00310,ko00362,ko00380,ko00410,ko00640,ko00650,ko00903,ko00930,ko01040,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00362,map00380,map00410,map00640,map00650,map00903,map00930,map01040,map01100,map01110,map01120,map01130,map01200,map01212 M00032,M00087 R01975,R03026,R03045,R03276,R04137,R04170,R04203,R04204,R04224,R04737,R04738,R04739,R04740,R04741,R04744,R04745,R04746,R04748,R04749,R05066,R05305,R06411,R06412,R06941,R06942,R07935,R07951,R08093,R08094 RC00029,RC00099,RC00117,RC00241,RC00525,RC00831,RC00834,RC00896,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 - - - 3HCDH,3HCDH_N,ECH_1 k59_1228001_1 1385515.N791_14835 3.22e-27 114.0 COG0643@1|root,COG0784@1|root,COG2198@1|root,COG0643@2|Bacteria,COG0784@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,1RMS6@1236|Gammaproteobacteria,1X3AY@135614|Xanthomonadales 135614|Xanthomonadales T Chemotaxis protein histidine kinase and related kinases pilL - - ko:K02487,ko:K06596 ko02020,ko02025,map02020,map02025 M00507 - - ko00000,ko00001,ko00002,ko01001,ko02022,ko02035 - - - CheW,H-kinase_dim,HATPase_c,Hpt,Response_reg k59_1338288_1 357804.Ping_0302 2.82e-63 210.0 COG1396@1|root,COG1396@2|Bacteria,1R3Z8@1224|Proteobacteria,1RRMV@1236|Gammaproteobacteria 1236|Gammaproteobacteria K transcriptional - - - - - - - - - - - - DUF3612,HTH_19,HTH_3,Peptidase_M78 k59_1788418_1 287.DR97_1963 1.79e-83 268.0 COG2271@1|root,COG2271@2|Bacteria,1MWYR@1224|Proteobacteria,1RR7T@1236|Gammaproteobacteria,1YD63@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria G Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 k59_211451_1 1298593.TOL_0252 2.42e-72 222.0 COG1704@1|root,COG1704@2|Bacteria,1MVH0@1224|Proteobacteria,1RP1N@1236|Gammaproteobacteria,1XI0A@135619|Oceanospirillales 135619|Oceanospirillales S LemA family - - - ko:K03744 - - - - ko00000 - - - LemA k59_211451_2 1134474.O59_001230 7.68e-69 230.0 COG0501@1|root,COG0501@2|Bacteria,1MVU4@1224|Proteobacteria,1RPJ5@1236|Gammaproteobacteria,1FG42@10|Cellvibrio 1236|Gammaproteobacteria O Peptidase family M48 - - - ko:K03799 - M00743 - - ko00000,ko00002,ko01000,ko01002 - - - Peptidase_M48 k59_773121_1 316407.85676707 1.2e-30 110.0 COG3149@1|root,COG3149@2|Bacteria,1NGFT@1224|Proteobacteria,1SIFJ@1236|Gammaproteobacteria 1236|Gammaproteobacteria U PFAM General secretion pathway, M protein xcsM - - ko:K02462 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - T2SSM k59_773121_2 316407.85676708 1.78e-80 248.0 COG3297@1|root,COG3297@2|Bacteria 2|Bacteria U Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins gspL GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K02461 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - GspL_C,T2SSL k59_1228004_1 888064.HMPREF9088_1536 5.32e-16 80.9 COG0635@1|root,COG0635@2|Bacteria,1TPES@1239|Firmicutes,4HA60@91061|Bacilli,4AZGX@81852|Enterococcaceae 91061|Bacilli H Involved in the biosynthesis of porphyrin-containing compound hemN GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 - - - - - - - - - - HemN_C,Radical_SAM k59_211452_1 382464.ABSI01000012_gene2223 6.96e-29 122.0 COG5002@1|root,COG5002@2|Bacteria,46Z3U@74201|Verrucomicrobia,2IWP7@203494|Verrucomicrobiae 203494|Verrucomicrobiae T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA,Response_reg k59_490811_1 1288494.EBAPG3_9210 1.15e-66 227.0 COG0587@1|root,COG0587@2|Bacteria,1MUIF@1224|Proteobacteria,2VH3F@28216|Betaproteobacteria,3727S@32003|Nitrosomonadales 28216|Betaproteobacteria L TIGRFAM DNA polymerase III, alpha subunit dnaE - 2.7.7.7 ko:K02337 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon k59_999137_1 573413.Spirs_3882 9.64e-08 52.8 COG3384@1|root,COG3384@2|Bacteria,2JA2G@203691|Spirochaetes 203691|Spirochaetes S Extradiol ring-cleavage dioxygenase, class III enzyme, subunit B - - - - - - - - - - - - LigB k59_999137_2 1411123.JQNH01000001_gene2738 8.68e-15 72.4 COG3474@1|root,COG3474@2|Bacteria,1MZGS@1224|Proteobacteria,2UCUT@28211|Alphaproteobacteria 28211|Alphaproteobacteria C cytochrome cycA - - ko:K08738 ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416 M00595 R10151 RC03151,RC03152 ko00000,ko00001,ko00002 3.D.4.6 - - Cytochrom_C k59_1281802_1 880072.Desac_0181 1.18e-101 310.0 COG0104@1|root,COG0104@2|Bacteria,1MU5B@1224|Proteobacteria,42M9E@68525|delta/epsilon subdivisions,2WJ3F@28221|Deltaproteobacteria,2MQY1@213462|Syntrophobacterales 28221|Deltaproteobacteria F Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP purA GO:0003674,GO:0003824,GO:0004019,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046033,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.4.4 ko:K01939 ko00230,ko00250,ko01100,map00230,map00250,map01100 M00049 R01135 RC00458,RC00459 ko00000,ko00001,ko00002,ko01000 - - - Adenylsucc_synt k59_43829_1 511145.b2298 2.43e-100 304.0 COG1288@1|root,COG1288@2|Bacteria,1MY1J@1224|Proteobacteria,1RS2M@1236|Gammaproteobacteria,3XQGN@561|Escherichia 1236|Gammaproteobacteria S antiporter activity yfcC GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - - - - - - - - - - DcuC k59_1281805_2 1229909.NSED_06835 1.36e-76 229.0 COG1990@1|root,arCOG04228@2157|Archaea,41ST1@651137|Thaumarchaeota 651137|Thaumarchaeota J Peptidyl-tRNA hydrolase PTH2 - - 3.1.1.29 ko:K04794 - - - - ko00000,ko01000,ko03012 - - - PTH2 k59_1281805_3 436308.Nmar_1220 2.18e-28 110.0 COG0644@1|root,arCOG00570@2157|Archaea,41SB5@651137|Thaumarchaeota 651137|Thaumarchaeota C Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains - - - - - - - - - - - - - k59_892228_1 228405.HNE_2583 1.71e-19 86.7 COG3794@1|root,COG3794@2|Bacteria,1RHQU@1224|Proteobacteria,2UBHY@28211|Alphaproteobacteria,43ZX5@69657|Hyphomonadaceae 28211|Alphaproteobacteria C PFAM blue (type 1) copper domain protein - - - - - - - - - - - - - k59_892228_2 1462526.BN990_03019 1.84e-19 93.2 COG1164@1|root,COG1164@2|Bacteria,1TR7D@1239|Firmicutes,4HA0P@91061|Bacilli,4C4UU@84406|Virgibacillus 91061|Bacilli E Oligopeptidase F pepF1_3 - - - - - - - - - - - Peptidase_M3,Peptidase_M3_N k59_269140_1 436308.Nmar_0042 3.62e-11 61.6 COG1100@1|root,arCOG01225@2157|Archaea,41T0A@651137|Thaumarchaeota 651137|Thaumarchaeota S Conserved hypothetical ATP binding protein - - - ko:K06883 - - - - ko00000 - - - ATP_bind_1 k59_269140_2 1229909.NSED_09830 1.88e-79 244.0 COG0083@1|root,arCOG01027@2157|Archaea,41S89@651137|Thaumarchaeota 651137|Thaumarchaeota E Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate thrB - 2.7.1.39 ko:K00872 ko00260,ko01100,ko01110,ko01120,ko01230,map00260,map01100,map01110,map01120,map01230 M00018 R01771 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - GHMP_kinases_C,GHMP_kinases_N k59_1678491_2 338963.Pcar_0405 1.26e-69 227.0 COG1206@1|root,COG1206@2|Bacteria,1MWNQ@1224|Proteobacteria,42MTS@68525|delta/epsilon subdivisions,2WJ50@28221|Deltaproteobacteria,43SD3@69541|Desulfuromonadales 28221|Deltaproteobacteria J Glucose inhibited division protein A trmFO GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901363 2.1.1.74 ko:K04094 - - - - ko00000,ko01000,ko03016,ko03036 - - - GIDA k59_99758_1 1121937.AUHJ01000001_gene346 6.45e-123 357.0 COG0583@1|root,COG0583@2|Bacteria,1MU8N@1224|Proteobacteria,1RN7T@1236|Gammaproteobacteria,464YF@72275|Alteromonadaceae 1236|Gammaproteobacteria K Transcriptional regulator cysB GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0009314,GO:0009628,GO:0010165,GO:0010212,GO:0042802,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0097159,GO:1901363 - ko:K13634 - - - - ko00000,ko03000 - - - HTH_1,LysR_substrate k59_546185_1 1191523.MROS_1521 9.15e-96 286.0 COG3271@1|root,COG3271@2|Bacteria 2|Bacteria - - - - - ko:K02450 - M00331 - - ko00000,ko00002,ko02044 9.B.42 - - DUF3335,Peptidase_C39,Peptidase_C39_2,Peptidase_C70,TPR_16,TPR_19,TPR_2,TPR_8 k59_661513_1 436308.Nmar_1105 3.84e-160 466.0 COG0556@1|root,arCOG04748@2157|Archaea,41T0H@651137|Thaumarchaeota 651137|Thaumarchaeota L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage uvrB - - ko:K03702 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - Helicase_C,ResIII,UVR,UvrB k59_154278_1 996637.SGM_0406 3.95e-113 338.0 COG1702@1|root,COG1702@2|Bacteria,2GK0W@201174|Actinobacteria 201174|Actinobacteria T phosphate starvation-inducible protein PhoH phoH - - ko:K06217 - - - - ko00000 - - - PhoH k59_1678507_2 504472.Slin_5365 6.45e-81 250.0 COG1131@1|root,COG1131@2|Bacteria,4NJ0D@976|Bacteroidetes,47K40@768503|Cytophagia 976|Bacteroidetes V ATPases associated with a variety of cellular activities - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_327318_1 63737.Npun_R4716 8.12e-15 72.0 COG3556@1|root,COG3556@2|Bacteria,1G6VI@1117|Cyanobacteria,1HP8E@1161|Nostocales 1117|Cyanobacteria S Predicted membrane protein (DUF2214) - - - ko:K08983 - - - - ko00000 - - - DUF2214 k59_327318_2 13690.CP98_01193 8.57e-21 90.5 COG0604@1|root,COG0604@2|Bacteria,1MX8A@1224|Proteobacteria,2TR1J@28211|Alphaproteobacteria,2K115@204457|Sphingomonadales 204457|Sphingomonadales C NADPH quinone - - - - - - - - - - - - ADH_N,ADH_zinc_N,ADH_zinc_N_2 k59_1570991_1 383372.Rcas_3623 6.09e-32 120.0 COG3634@1|root,COG3634@2|Bacteria,2G6SQ@200795|Chloroflexi,376IM@32061|Chloroflexia 32061|Chloroflexia O TIGRFAM glutaredoxin-like domain protein - - - - - - - - - - - - Thioredoxin_3 k59_722311_1 1242864.D187_001980 1.97e-14 72.4 COG3724@1|root,COG3724@2|Bacteria,1MUJV@1224|Proteobacteria,42MC2@68525|delta/epsilon subdivisions,2WM3J@28221|Deltaproteobacteria 28221|Deltaproteobacteria E Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2) astB - 3.5.3.23 ko:K01484 ko00330,ko01100,map00330,map01100 - R04189 RC00024 ko00000,ko00001,ko01000 - - - AstB k59_722311_2 1254432.SCE1572_04560 7.09e-57 193.0 COG1012@1|root,COG1012@2|Bacteria 2|Bacteria C belongs to the aldehyde dehydrogenase family astD GO:0003674,GO:0003824,GO:0004029,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0055114 1.2.1.71 ko:K06447 ko00330,ko01100,map00330,map01100 - R05049 RC00080 ko00000,ko00001,ko01000 - - iECABU_c1320.ECABU_c20030,iEcHS_1320.EcHS_A1829,ic_1306.c2146 Aldedh k59_1228039_2 1122137.AQXF01000003_gene1963 2.7e-50 177.0 COG4772@1|root,COG4772@2|Bacteria,1NTC4@1224|Proteobacteria,2U3CZ@28211|Alphaproteobacteria 28211|Alphaproteobacteria P TonB dependent receptor - - - - - - - - - - - - Plug,TonB_dep_Rec k59_1513449_1 1007104.SUS17_2827 8.92e-95 288.0 COG0446@1|root,COG0446@2|Bacteria,1QSG6@1224|Proteobacteria,2TUP1@28211|Alphaproteobacteria,2K2NT@204457|Sphingomonadales 204457|Sphingomonadales S Pyridine nucleotide-disulphide oxidoreductase - - 1.8.5.4 ko:K17218 ko00920,map00920 - R10152 RC03155 ko00000,ko00001,ko01000 - - - Pyr_redox_2 k59_1623538_1 224911.27351137 2.19e-07 56.2 COG1020@1|root,COG1020@2|Bacteria,1N7HY@1224|Proteobacteria,2TRZV@28211|Alphaproteobacteria,3JSC2@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria Q Protein of unknown function (DUF1298) MA20_16710 - - - - - - - - - - - DUF1298,WES_acyltransf k59_99783_1 155864.EDL933_3712 6.91e-08 52.4 COG1879@1|root,COG1879@2|Bacteria,1PCD4@1224|Proteobacteria,1RPZE@1236|Gammaproteobacteria,3XNDR@561|Escherichia 1236|Gammaproteobacteria G ABC transporter yphF - - ko:K02058 - M00221 - - ko00000,ko00002,ko02000 3.A.1.2 - - Peripla_BP_4 k59_99783_2 316407.1799964 2.9e-126 372.0 COG1129@1|root,COG1129@2|Bacteria,1MU22@1224|Proteobacteria,1S1ND@1236|Gammaproteobacteria,3XNWJ@561|Escherichia 1236|Gammaproteobacteria P ABC transporter, ATP-binding protein yphE - 3.6.3.17 ko:K02056 - M00221 - - ko00000,ko00002,ko01000,ko02000 3.A.1.2 - - ABC_tran k59_43874_1 1121374.KB891575_gene1130 1.23e-70 226.0 COG0493@1|root,COG0493@2|Bacteria,1MU2H@1224|Proteobacteria,1RMY7@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Glutamate synthase gltD GO:0003674,GO:0003824,GO:0004355,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0015930,GO:0016053,GO:0016491,GO:0016638,GO:0016639,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045181,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.4.1.13,1.4.1.14 ko:K00266 ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 - R00093,R00114,R00248 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - iEC042_1314.EC042_3503,iYL1228.KPN_03625 Fer4_11,Fer4_20,Pyr_redox_2 k59_43874_2 1268237.G114_02574 1.26e-14 72.0 COG0407@1|root,COG0407@2|Bacteria,1MUG1@1224|Proteobacteria,1RMDH@1236|Gammaproteobacteria,1Y46X@135624|Aeromonadales 135624|Aeromonadales H Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III hemE - 4.1.1.37 ko:K01599 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R03197,R04972 RC00872 ko00000,ko00001,ko00002,ko01000 - - - URO-D k59_1338325_1 1226994.AMZB01000125_gene3101 7.01e-77 244.0 COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,1RNB5@1236|Gammaproteobacteria,1YD22@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria C CoA-transferase family III coaT - - - - - - - - - - - CoA_transf_3 k59_661576_1 1158760.AQXP01000052_gene1709 3.77e-08 55.1 COG2199@1|root,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria,1S6MK@1236|Gammaproteobacteria,1WW1I@135613|Chromatiales 135613|Chromatiales T diguanylate cyclase - - - - - - - - - - - - GGDEF,Response_reg k59_661576_2 1335757.SPICUR_02750 8.87e-26 104.0 COG0414@1|root,COG0414@2|Bacteria,1MV1S@1224|Proteobacteria,1RMEG@1236|Gammaproteobacteria,1WW2E@135613|Chromatiales 135613|Chromatiales H Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate panC - 6.3.2.1 ko:K01918 ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110 M00119 R02473 RC00096,RC00141 ko00000,ko00001,ko00002,ko01000 - - - Pantoate_ligase k59_892318_1 314260.PB2503_00350 5.96e-61 211.0 COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,2TRWM@28211|Alphaproteobacteria 28211|Alphaproteobacteria P Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_1060353_1 91464.S7335_5518 8.88e-14 74.7 COG1651@1|root,COG1651@2|Bacteria,1G379@1117|Cyanobacteria,1H077@1129|Synechococcus 1117|Cyanobacteria O thioredoxin domain - - - - - - - - - - - - Thioredoxin_4 k59_43887_1 1328313.DS2_05220 0.000113 43.5 COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,1RMBS@1236|Gammaproteobacteria,464D8@72275|Alteromonadaceae 1236|Gammaproteobacteria NU COG2804 Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB gspE - - ko:K02454 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - T2SSE,T2SSE_N k59_1339991_2 1522072.IL54_1435 9.56e-93 293.0 COG2010@1|root,COG4993@1|root,COG2010@2|Bacteria,COG4993@2|Bacteria,1R7EM@1224|Proteobacteria,2UPM6@28211|Alphaproteobacteria,2K9IJ@204457|Sphingomonadales 204457|Sphingomonadales C PQQ-like domain - - 1.1.9.1 ko:K17760 - - - - ko00000,ko01000 - - - Cytochrome_CBB3,PQQ k59_1402745_1 1380391.JIAS01000014_gene2300 4.7e-95 297.0 COG0556@1|root,COG0556@2|Bacteria,1MUFK@1224|Proteobacteria,2TQSP@28211|Alphaproteobacteria,2JPXK@204441|Rhodospirillales 204441|Rhodospirillales L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage uvrB - - ko:K03702 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - Helicase_C,ResIII,UVR,UvrB k59_1114749_1 1158756.AQXQ01000007_gene272 7.7e-55 185.0 COG0667@1|root,COG0667@2|Bacteria,1RK6Z@1224|Proteobacteria,1SKN5@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Aldo/keto reductase family - - - - - - - - - - - - Aldo_ket_red k59_212976_1 1454004.AW11_02857 0.000702 41.2 COG0651@1|root,COG0651@2|Bacteria,1MV6V@1224|Proteobacteria 1224|Proteobacteria CP formate hydrogenlyase subunit 3 multisubunit Na H antiporter, MnhD subunit nuoL3 - - ko:K05568,ko:K12137 - - - - ko00000,ko01000,ko02000 2.A.63.1,2.A.63.2 - - Proton_antipo_M k59_212976_2 1121106.JQKB01000070_gene858 2.38e-10 62.8 COG4663@1|root,COG4663@2|Bacteria,1MUXI@1224|Proteobacteria,2TQVW@28211|Alphaproteobacteria,2JPP7@204441|Rhodospirillales 204441|Rhodospirillales Q Part of the tripartite ATP-independent periplasmic (TRAP) transport system - - - - - - - - - - - - DctP k59_662964_1 1415778.JQMM01000001_gene456 4.49e-75 238.0 COG2267@1|root,COG2267@2|Bacteria,1RAQZ@1224|Proteobacteria,1S2YX@1236|Gammaproteobacteria,1J5TW@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria I COG2267 Lysophospholipase pldB - 3.1.1.5 ko:K01048 ko00564,map00564 - - - ko00000,ko00001,ko01000 - - - Hydrolase_4 k59_385644_2 1122927.KB895414_gene5000 7.28e-06 48.9 COG1131@1|root,COG1131@2|Bacteria,1TPUP@1239|Firmicutes,4HDFX@91061|Bacilli,26V1G@186822|Paenibacillaceae 91061|Bacilli V ABC-type multidrug transport system, ATPase component - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_1737697_1 566466.NOR53_465 8.44e-59 199.0 COG3746@1|root,COG3746@2|Bacteria 2|Bacteria - - - - - ko:K07221 - - - - ko00000,ko02000 1.B.5.1 - - Porin_O_P k59_329023_1 10871.VG424_BPPF1 6.27e-61 203.0 4QBME@10239|Viruses,4QUKP@29258|ssDNA viruses,4QP4G@10860|Inoviridae 10860|Inoviridae S Zonular occludens toxin (Zot) - - - - - - - - - - - - - k59_1797050_1 765869.BDW_13730 1.46e-32 128.0 COG3178@1|root,COG3178@2|Bacteria,1MXCH@1224|Proteobacteria,42TUJ@68525|delta/epsilon subdivisions,2MSY4@213481|Bdellovibrionales,2WQ4U@28221|Deltaproteobacteria 213481|Bdellovibrionales S phosphotransferase related to Ser Thr protein kinases - - 2.7.1.221 ko:K07102 ko00520,ko01100,map00520,map01100 - R08968,R11024 RC00002,RC00078 ko00000,ko00001,ko01000 - - - APH k59_840998_1 96561.Dole_2815 1.3e-79 260.0 COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,42NB6@68525|delta/epsilon subdivisions,2WIWE@28221|Deltaproteobacteria,2MHQQ@213118|Desulfobacterales 28221|Deltaproteobacteria M Belongs to the peptidase S1C family degP - 3.4.21.107 ko:K04771 ko01503,ko02020,map01503,map02020 M00728 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 - - - PDZ_2,Trypsin_2 k59_1460821_2 1122137.AQXF01000002_gene491 9.13e-62 194.0 COG0259@1|root,COG0259@2|Bacteria,1NZUU@1224|Proteobacteria,2TT1U@28211|Alphaproteobacteria 28211|Alphaproteobacteria H Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) pdxH GO:0003674,GO:0003824,GO:0004733,GO:0006081,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0016491,GO:0016638,GO:0016641,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0034641,GO:0042364,GO:0042816,GO:0042819,GO:0042822,GO:0042823,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046184,GO:0046483,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 1.4.3.5 ko:K00275 ko00750,ko01100,ko01120,map00750,map01100,map01120 M00124 R00277,R00278,R01710,R01711 RC00048,RC00116 ko00000,ko00001,ko00002,ko01000 - - - PNP_phzG_C,Putative_PNPOx k59_1632517_1 391598.FBBAL38_09629 1.97e-16 78.2 COG3746@1|root,COG3746@2|Bacteria,4NH24@976|Bacteroidetes,1HXMY@117743|Flavobacteriia 976|Bacteroidetes P PFAM Phosphate-selective porin O and P - - - - - - - - - - - - Porin_O_P k59_1632517_2 391598.FBBAL38_09624 6.92e-109 330.0 COG2866@1|root,COG2866@2|Bacteria,4PJ2J@976|Bacteroidetes,1I7B9@117743|Flavobacteriia 976|Bacteroidetes M Zn_pept - - - - - - - - - - - - Peptidase_M14 k59_1068814_2 710685.MycrhN_0078 3.66e-17 85.1 COG1028@1|root,COG1028@2|Bacteria,2GW8A@201174|Actinobacteria,233Z6@1762|Mycobacteriaceae 201174|Actinobacteria IQ Enoyl-(Acyl carrier protein) reductase - - - - - - - - - - - - adh_short_C2 k59_278271_1 1238182.C882_0258 5.44e-44 161.0 COG0845@1|root,COG0845@2|Bacteria,1MUFW@1224|Proteobacteria,2U2CU@28211|Alphaproteobacteria,2JQW0@204441|Rhodospirillales 204441|Rhodospirillales M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - ko:K03585 ko01501,ko01503,map01501,map01503 M00646,M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000,ko03036 2.A.6.2,8.A.1.6 - - HlyD_D23 k59_1068827_1 1197477.IA57_07775 1e-51 180.0 COG1073@1|root,COG1073@2|Bacteria,4PMNT@976|Bacteroidetes,1HZRQ@117743|Flavobacteriia 976|Bacteroidetes N alpha beta - - - - - - - - - - - - DUF676,PGAP1 k59_1007587_1 1122137.AQXF01000001_gene3207 2.22e-13 70.5 294XR@1|root,2ZSAQ@2|Bacteria 2|Bacteria S Heavy-metal resistance - - - - - - - - - - - - Metal_resist k59_392999_1 1144305.PMI02_00722 6.94e-10 60.5 COG5361@1|root,COG5361@2|Bacteria,1R4D9@1224|Proteobacteria,2VCIZ@28211|Alphaproteobacteria,2K2ET@204457|Sphingomonadales 204457|Sphingomonadales S Protein of unknown function (DUF1214) - - - - - - - - - - - - DUF1214 k59_392999_2 1144305.PMI02_00723 4e-137 393.0 COG0583@1|root,COG0583@2|Bacteria,1MWY0@1224|Proteobacteria,2U2F2@28211|Alphaproteobacteria,2K1M3@204457|Sphingomonadales 204457|Sphingomonadales K Transcriptional regulator - - - ko:K03566 ko02026,map02026 - - - ko00000,ko00001,ko03000 - - - HTH_1,LysR_substrate k59_392999_3 555793.WSK_4245 4.2e-09 54.3 COG2967@1|root,COG2967@2|Bacteria,1MZ2Z@1224|Proteobacteria,2U9JM@28211|Alphaproteobacteria,2K4GR@204457|Sphingomonadales 204457|Sphingomonadales P protein affecting Mg2 Co2 transport apaG - - ko:K06195 - - - - ko00000 - - - DUF525 k59_1632543_1 1227349.C170_00204 1.09e-53 178.0 COG0300@1|root,COG0300@2|Bacteria,1UZHA@1239|Firmicutes,4HA3H@91061|Bacilli,274QV@186822|Paenibacillaceae 91061|Bacilli S Belongs to the short-chain dehydrogenases reductases (SDR) family - - - ko:K07124 - - - - ko00000 - - - adh_short k59_108630_1 1122137.AQXF01000004_gene1652 3.6e-63 218.0 COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,2TRZD@28211|Alphaproteobacteria 28211|Alphaproteobacteria P TIGRFAM ATPase, P-type (transporting), HAD superfamily, subfamily IC - - 3.6.3.8 ko:K01537 - - - - ko00000,ko01000 3.A.3.2 - - Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3 k59_1347274_1 1131812.JQMS01000001_gene1182 1.49e-113 342.0 COG3378@1|root,COG3378@2|Bacteria,4NG1J@976|Bacteroidetes,1ICR9@117743|Flavobacteriia,2NUCQ@237|Flavobacterium 976|Bacteroidetes S D5 N terminal like - - - ko:K06919 - - - - ko00000 - - - D5_N,Pox_D5 k59_1687752_1 1189619.pgond44_14518 3e-76 234.0 2ABZ1@1|root,311GG@2|Bacteria,4NNKH@976|Bacteroidetes,1I2E7@117743|Flavobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_1687753_1 870187.Thini_4190 1.01e-62 210.0 COG0358@1|root,COG0358@2|Bacteria,1MUHC@1224|Proteobacteria,1RMGA@1236|Gammaproteobacteria,45ZSG@72273|Thiotrichales 72273|Thiotrichales L RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication dnaG - - ko:K02316 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB_bind,DnaG_DnaB_bind,Toprim_2,Toprim_4,Toprim_N,zf-CHC2 k59_220252_1 316407.85674654 1.91e-72 228.0 COG0624@1|root,COG0624@2|Bacteria,1MVUX@1224|Proteobacteria,1RPPD@1236|Gammaproteobacteria,3XPWH@561|Escherichia 1236|Gammaproteobacteria E Involved in the anaerobic nitrogen utilization via the assimilation of allantoin. Catalyzes specifically the hydrolysis of allantoate to yield CO2, NH3 and S-ureidoglycine, which is unstable and readily undergoes a second deamination by S-ureidoglycine aminohydrolase AllE to yield S-ureidoglycolate and NH3. In vivo, the spontaneous release of S-ureidoglycolate and ammonia from S- ureidoglycine appears to be too slow to sustain an efficient flux of nitrogen allC GO:0000255,GO:0000256,GO:0003674,GO:0003824,GO:0005488,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009056,GO:0009442,GO:0009987,GO:0016787,GO:0016810,GO:0016813,GO:0017144,GO:0030145,GO:0034641,GO:0042737,GO:0043167,GO:0043169,GO:0043603,GO:0043605,GO:0044237,GO:0044248,GO:0044270,GO:0046483,GO:0046700,GO:0046872,GO:0046914,GO:0047652,GO:0071704,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575 3.5.3.9 ko:K02083 ko00230,ko01120,map00230,map01120 - R02423 RC00064 ko00000,ko00001,ko01000,ko01002 - - iECH74115_1262.ECH74115_0617,iECSP_1301.ECSP_0590,iECUMN_1333.ECUMN_0556,iECs_1301.ECs0578,iZ_1308.Z0671 Peptidase_M20 k59_220252_2 316407.85674655 3.49e-55 181.0 COG2055@1|root,COG2055@2|Bacteria,1MWQY@1224|Proteobacteria,1RSKW@1236|Gammaproteobacteria,3XQXU@561|Escherichia 1236|Gammaproteobacteria C AllD plays a pivotal role as a metabolic branch-point enzyme in nitrogen utilization via the assimilation of allantoin. It is able to utilize allantoin as a sole source of nitrogen under anaerobic conditions. Catalyzes the oxidation of ureidoglycolate to oxalurate allD GO:0000255,GO:0000256,GO:0003674,GO:0003824,GO:0006807,GO:0008150,GO:0008152,GO:0009040,GO:0009056,GO:0009442,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0017144,GO:0034641,GO:0042737,GO:0043603,GO:0043605,GO:0044237,GO:0044248,GO:0044270,GO:0046483,GO:0046700,GO:0055114,GO:0071704,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575 1.1.1.350 ko:K00073 ko00230,ko01120,map00230,map01120 - R02935,R02936 RC00169 ko00000,ko00001,ko01000 - - iEC042_1314.EC042_0560 Ldh_2 k59_670127_1 565045.NOR51B_2425 4.73e-69 228.0 COG0457@1|root,COG0457@2|Bacteria,1MVMG@1224|Proteobacteria,1RU5N@1236|Gammaproteobacteria,1J9C4@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S COG0457 FOG TPR repeat - - - - - - - - - - - - Sulfotransfer_3,TPR_1,TPR_16,TPR_19,TPR_2,TPR_8 k59_1180574_1 1121937.AUHJ01000006_gene2476 5.39e-54 179.0 COG0628@1|root,COG0628@2|Bacteria,1MW0B@1224|Proteobacteria,1RPVP@1236|Gammaproteobacteria,465AI@72275|Alteromonadaceae 1236|Gammaproteobacteria S permease perM GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944 - ko:K03548 - - - - ko00000,ko02000 2.A.86.1 - - AI-2E_transport k59_499239_1 290512.Paes_0629 1.03e-99 300.0 COG3344@1|root,COG3344@2|Bacteria 2|Bacteria L reverse transcriptase - - - - - - - - - - - - GIIM,RVT_1 k59_108651_1 656024.FsymDg_1969 0.000541 46.6 COG0125@1|root,COG0125@2|Bacteria,2IKE2@201174|Actinobacteria 201174|Actinobacteria F Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis - - 2.7.4.9 ko:K00943 ko00240,ko01100,map00240,map01100 M00053 R02094,R02098 RC00002 ko00000,ko00001,ko00002,ko01000 - - - Thymidylate_kin k59_1522212_1 207954.MED92_13823 7.03e-46 167.0 COG0643@1|root,COG0643@2|Bacteria,1MUAG@1224|Proteobacteria,1RMS6@1236|Gammaproteobacteria,1XHW5@135619|Oceanospirillales 135619|Oceanospirillales T Chemotaxis protein histidine kinase and related cheA - 2.7.13.3 ko:K03407 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 - - - CheW,CheY-binding,H-kinase_dim,HATPase_c,Hpt k59_393026_2 393595.ABO_1306 3.18e-49 165.0 COG0558@1|root,COG0558@2|Bacteria,1RCZ7@1224|Proteobacteria,1S465@1236|Gammaproteobacteria,1XJF2@135619|Oceanospirillales 135619|Oceanospirillales I Belongs to the CDP-alcohol phosphatidyltransferase class-I family pgsA - 2.7.8.41,2.7.8.5 ko:K00995,ko:K08744 ko00564,ko01100,map00564,map01100 - R01801,R02030 RC00002,RC00017,RC02795 ko00000,ko00001,ko01000 - - - CDP-OH_P_transf k59_1068852_1 926569.ANT_27800 4.21e-106 321.0 COG3385@1|root,COG3385@2|Bacteria 2|Bacteria L transposase activity - - - - - - - - - - - - DDE_Tnp_1 k59_1291258_1 1144305.PMI02_04641 9.96e-68 208.0 COG3293@1|root,COG3293@2|Bacteria,1P5HD@1224|Proteobacteria,2TUQI@28211|Alphaproteobacteria,2K5AQ@204457|Sphingomonadales 204457|Sphingomonadales L Transposase DDE domain - - - - - - - - - - - - DDE_Tnp_1,DDE_Tnp_1_2 k59_1121807_1 626418.bglu_2g00380 6.1e-08 59.3 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2VHSB@28216|Betaproteobacteria,1K034@119060|Burkholderiaceae 28216|Betaproteobacteria T response regulator zraR - - - - - - - - - - - HTH_8,Response_reg,Sigma54_activat k59_163087_1 349161.Dred_2177 2.47e-100 304.0 COG1744@1|root,COG1744@2|Bacteria,1TPEU@1239|Firmicutes,248IH@186801|Clostridia,260AZ@186807|Peptococcaceae 186801|Clostridia S PFAM Basic membrane - - - ko:K07335 - - - - ko00000 - - - Bmp k59_1460861_1 1197477.IA57_11320 7.65e-53 191.0 2DC13@1|root,2ZCBS@2|Bacteria,4NMSX@976|Bacteroidetes,1I1WF@117743|Flavobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_1236389_1 1229909.NSED_00155 8.67e-138 393.0 COG0842@1|root,arCOG01467@2157|Archaea,41SH0@651137|Thaumarchaeota 651137|Thaumarchaeota V ABC-2 type transporter - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane k59_670155_1 555779.Dthio_PD3775 0.00044 40.8 COG4226@1|root,COG4226@2|Bacteria,1PTX8@1224|Proteobacteria,4328E@68525|delta/epsilon subdivisions 1224|Proteobacteria L CopG domain protein DNA-binding domain protein - - - - - - - - - - - - - k59_163096_1 1122137.AQXF01000005_gene984 7e-08 53.1 2E7DT@1|root,331WV@2|Bacteria,1N62R@1224|Proteobacteria,2UNCF@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - - k59_163096_2 1122137.AQXF01000005_gene985 2.69e-158 449.0 COG1131@1|root,COG1131@2|Bacteria,1R3XF@1224|Proteobacteria,2U2TQ@28211|Alphaproteobacteria 28211|Alphaproteobacteria V ATPases associated with a variety of cellular activities - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_163096_3 1122137.AQXF01000005_gene986 8.44e-49 157.0 COG1725@1|root,COG1725@2|Bacteria,1MZG9@1224|Proteobacteria,2UBQ4@28211|Alphaproteobacteria 28211|Alphaproteobacteria K Transcriptional regulator - - - ko:K07979 - - - - ko00000,ko03000 - - - GntR k59_1409952_1 765910.MARPU_16390 4.03e-72 240.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1WVZ7@135613|Chromatiales 135613|Chromatiales T Diguanylate cyclase - - - - - - - - - - - - EAL,GGDEF,HAMP,PAS,PAS_3,PAS_4,PAS_9,Response_reg k59_901256_1 555793.WSK_2830 3.57e-122 365.0 COG0449@1|root,COG0449@2|Bacteria,1MW4K@1224|Proteobacteria,2TQPM@28211|Alphaproteobacteria,2K017@204457|Sphingomonadales 204457|Sphingomonadales M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source glmS - 2.6.1.16 ko:K00820 ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931 - R00768 RC00010,RC00163,RC02752 ko00000,ko00001,ko01000,ko01002 - - - GATase_6,SIS k59_731329_1 1445613.JALM01000126_gene1797 2.39e-27 121.0 COG1014@1|root,COG4231@1|root,COG1014@2|Bacteria,COG4231@2|Bacteria,2GKBW@201174|Actinobacteria,4E0GX@85010|Pseudonocardiales 201174|Actinobacteria C Pyruvate ferredoxin/flavodoxin oxidoreductase - - 1.2.7.8 ko:K00179,ko:K04090 - - - - br01601,ko00000,ko01000 - - - Fer4,POR,POR_N,TPP_enzyme_C k59_1744749_1 1123288.SOV_1c02260 4.49e-67 215.0 COG2267@1|root,COG2267@2|Bacteria,1UNR7@1239|Firmicutes 1239|Firmicutes I Alpha/beta hydrolase family - - - - - - - - - - - - Abhydrolase_1 k59_731332_1 395493.BegalDRAFT_2979 1.81e-29 118.0 COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,1RMBS@1236|Gammaproteobacteria,45ZSX@72273|Thiotrichales 72273|Thiotrichales NU Type II IV secretion system protein pilB - - ko:K02652 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE,T2SSE_N k59_1347322_1 406552.NJ7G_0375 0.000533 47.0 COG1520@1|root,arCOG02556@2157|Archaea,2Y3JT@28890|Euryarchaeota,23ZIQ@183963|Halobacteria 183963|Halobacteria S PQQ enzyme repeat - - - - - - - - - - - - PQQ_3 k59_781563_2 391615.ABSJ01000052_gene1255 1.41e-33 128.0 COG0326@1|root,COG0326@2|Bacteria,1MUUE@1224|Proteobacteria,1RNWD@1236|Gammaproteobacteria,1J4YG@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O Molecular chaperone. Has ATPase activity htpG GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006950,GO:0006974,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0033554,GO:0042623,GO:0042802,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716 - ko:K04079 ko04141,ko04151,ko04217,ko04612,ko04621,ko04626,ko04657,ko04659,ko04914,ko04915,ko05200,ko05215,ko05418,map04141,map04151,map04217,map04612,map04621,map04626,map04657,map04659,map04914,map04915,map05200,map05215,map05418 - - - ko00000,ko00001,ko01009,ko03029,ko03051,ko03110,ko04131,ko04147 - - - HATPase_c,HATPase_c_3,HSP90 k59_220292_1 575540.Isop_2691 2.52e-78 247.0 COG0172@1|root,COG0172@2|Bacteria,2IXGP@203682|Planctomycetes 203682|Planctomycetes J Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) serS - 6.1.1.11 ko:K01875 ko00970,map00970 M00359,M00360 R03662,R08218 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Seryl_tRNA_N,tRNA-synt_2b k59_1068889_1 702113.PP1Y_AT14079 6.97e-79 240.0 COG0688@1|root,COG0688@2|Bacteria,1MW45@1224|Proteobacteria,2TRMG@28211|Alphaproteobacteria,2K019@204457|Sphingomonadales 204457|Sphingomonadales I Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer) psd - 4.1.1.65 ko:K01613 ko00564,ko01100,ko01110,map00564,map01100,map01110 M00093 R02055 RC00299 ko00000,ko00001,ko00002,ko01000 - - - PS_Dcarbxylase k59_278347_1 436308.Nmar_0996 1.6e-61 191.0 arCOG05565@1|root,arCOG05565@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_278347_2 1341151.ASZU01000004_gene320 7.16e-68 209.0 COG0225@1|root,COG0225@2|Bacteria,1TQ3E@1239|Firmicutes,4IQH5@91061|Bacilli,27DB5@186824|Thermoactinomycetaceae 91061|Bacilli O Peptide methionine sulfoxide reductase - - - - - - - - - - - - PMSR k59_1068891_1 1122137.AQXF01000001_gene2523 4.02e-31 118.0 COG4695@1|root,COG4695@2|Bacteria,1MUP5@1224|Proteobacteria,2TT33@28211|Alphaproteobacteria 28211|Alphaproteobacteria S portal protein - - - - - - - - - - - - Phage_portal k59_1068891_2 419610.Mext_1434 2.32e-43 155.0 COG5323@1|root,COG5323@2|Bacteria,1MW8S@1224|Proteobacteria,2TREI@28211|Alphaproteobacteria,1JUBX@119045|Methylobacteriaceae 28211|Alphaproteobacteria S Terminase RNaseH-like domain - - - - - - - - - - - - Terminase_6,Terminase_6C k59_1180623_1 768671.ThimaDRAFT_2883 3.15e-51 176.0 COG0564@1|root,COG0564@2|Bacteria,1MVDX@1224|Proteobacteria,1RPAN@1236|Gammaproteobacteria,1WW19@135613|Chromatiales 135613|Chromatiales J Responsible for synthesis of pseudouridine from uracil - - 5.4.99.24 ko:K06179 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2,S4 k59_1632601_2 522772.Dacet_0331 3.4e-27 111.0 COG2386@1|root,COG2386@2|Bacteria,2GF4W@200930|Deferribacteres 200930|Deferribacteres O CcmB protein - - - ko:K02194 ko02010,map02010 M00259 - - ko00000,ko00001,ko00002,ko02000 3.A.1.107 - - CcmB k59_1632601_3 1121445.ATUZ01000018_gene2385 0.000648 43.9 COG0755@1|root,COG0755@2|Bacteria,1MU61@1224|Proteobacteria,42RU4@68525|delta/epsilon subdivisions,2WNN7@28221|Deltaproteobacteria,2M9X3@213115|Desulfovibrionales 28221|Deltaproteobacteria O PFAM Cytochrome c assembly protein ccmC - - ko:K02195 ko02010,map02010 M00259 - - ko00000,ko00001,ko00002,ko02000 3.A.1.107 - - Cytochrom_C_asm k59_670209_1 1280946.HY29_02890 4.06e-80 265.0 COG1629@1|root,COG1629@2|Bacteria,1MV8W@1224|Proteobacteria,2U0EP@28211|Alphaproteobacteria,43W6Q@69657|Hyphomonadaceae 28211|Alphaproteobacteria P TIGRFAM TonB-dependent receptor - - - - - - - - - - - - Plug,TonB_dep_Rec k59_1797156_2 1121365.AQXB01000001_gene1237 1.65e-08 55.5 COG5479@1|root,COG5479@2|Bacteria 2|Bacteria M isomerase activity - - - - - - - - - - - - CHAP,Excalibur,LGFP,Peptidase_M15_4 k59_1744766_1 1123392.AQWL01000002_gene2063 2.02e-39 144.0 COG1215@1|root,COG1215@2|Bacteria,1RF99@1224|Proteobacteria,2VWU1@28216|Betaproteobacteria,1KSJR@119069|Hydrogenophilales 119069|Hydrogenophilales M Glycosyl transferase family 2 - - - - - - - - - - - - Glycos_transf_2 k59_556278_1 796620.VIBC2010_11156 2.68e-44 158.0 COG0579@1|root,COG0579@2|Bacteria,1N0QB@1224|Proteobacteria,1RN24@1236|Gammaproteobacteria,1XTAP@135623|Vibrionales 135623|Vibrionales S Hydroxyglutarate oxidase - - - ko:K15736 - - - - ko00000,ko01000 - - - DAO k59_221490_1 1484460.JSWG01000005_gene2679 2.07e-11 62.0 COG2825@1|root,COG2825@2|Bacteria,4NSCM@976|Bacteroidetes,1I19K@117743|Flavobacteriia 976|Bacteroidetes M membrane ompH - - ko:K06142 - - - - ko00000 - - - OmpH k59_221490_2 1347342.BN863_2720 1.67e-05 50.4 COG2825@1|root,COG2825@2|Bacteria,4NH46@976|Bacteroidetes,1HXE0@117743|Flavobacteriia 976|Bacteroidetes M membrane skp - - ko:K06142 - - - - ko00000 - - - OmpH k59_1689070_1 1172185.KB911509_gene239 2.69e-81 255.0 COG2124@1|root,COG2124@2|Bacteria,2GNZS@201174|Actinobacteria,4FVYT@85025|Nocardiaceae 201174|Actinobacteria Q Cytochrome P450 - - - - - - - - - - - - p450 k59_619515_1 1232410.KI421412_gene108 4.85e-10 58.9 COG0040@1|root,COG0040@2|Bacteria,1MUCY@1224|Proteobacteria,42N9N@68525|delta/epsilon subdivisions,2WIY9@28221|Deltaproteobacteria,43SEA@69541|Desulfuromonadales 28221|Deltaproteobacteria F ATP phosphoribosyltransferase hisG - 2.4.2.17 ko:K00765 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R01071 RC02819,RC03200 ko00000,ko00001,ko00002,ko01000 - - - HisG,HisG_C k59_619515_2 717785.HYPMC_0660 4.99e-15 77.8 COG0141@1|root,COG0141@2|Bacteria,1MUUF@1224|Proteobacteria,2TSBN@28211|Alphaproteobacteria,3N658@45401|Hyphomicrobiaceae 28211|Alphaproteobacteria E Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine hisD GO:0000105,GO:0003674,GO:0003824,GO:0004399,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0052803,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.23 ko:K00013 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R01158,R01163,R03012 RC00099,RC00242,RC00463 ko00000,ko00001,ko00002,ko01000 - - - Histidinol_dh k59_1348495_1 858215.Thexy_1155 5.85e-19 91.3 COG2804@1|root,COG2804@2|Bacteria,1TPGE@1239|Firmicutes,247KA@186801|Clostridia,42FCP@68295|Thermoanaerobacterales 186801|Clostridia NU PFAM Type II secretion system protein E xcpR - - ko:K02652 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE,T2SSE_N k59_1008704_1 1265313.HRUBRA_01380 8.55e-63 208.0 COG0471@1|root,COG0471@2|Bacteria,1MUSA@1224|Proteobacteria,1RPU5@1236|Gammaproteobacteria 1236|Gammaproteobacteria P COG0471 Di- and tricarboxylate transporters sdcS - - ko:K14445 - - - - ko00000,ko02000 2.A.47.1 - - Na_sulph_symp k59_1008704_2 1174684.EBMC1_17162 6.96e-09 56.6 COG0730@1|root,COG0730@2|Bacteria,1R3V4@1224|Proteobacteria,2TRYX@28211|Alphaproteobacteria,2K204@204457|Sphingomonadales 204457|Sphingomonadales S membrane transporter protein - - - - - - - - - - - - TauE k59_1581071_1 511.JT27_08480 2.52e-31 117.0 COG1846@1|root,COG1846@2|Bacteria,1MZE9@1224|Proteobacteria,2VT2T@28216|Betaproteobacteria,3T3W6@506|Alcaligenaceae 28216|Betaproteobacteria K MarR family transcriptional regulator badR - - - - - - - - - - - MarR,MarR_2 k59_902544_1 1120988.AXWV01000060_gene539 2.18e-119 353.0 COG0055@1|root,COG0055@2|Bacteria,1MUFU@1224|Proteobacteria,1RN6U@1236|Gammaproteobacteria,1Y3DS@135624|Aeromonadales 135624|Aeromonadales C Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits atpD - 3.6.3.14 ko:K02112 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - - ATP-synt_ab,ATP-synt_ab_N k59_1581073_1 1122137.AQXF01000002_gene653 4.14e-88 275.0 COG2211@1|root,COG2211@2|Bacteria,1MVUM@1224|Proteobacteria,2U8DJ@28211|Alphaproteobacteria 28211|Alphaproteobacteria G Sugar glycoside-pentoside-hexuronide - - - ko:K03292 - - - - ko00000 2.A.2 - - MFS_2 k59_445216_1 1123270.ATUR01000006_gene171 8.66e-151 434.0 COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,2TS1R@28211|Alphaproteobacteria,2JZW6@204457|Sphingomonadales 204457|Sphingomonadales I Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation - - 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N k59_671369_1 861299.J421_3436 4.38e-82 262.0 COG1154@1|root,COG1154@2|Bacteria,1ZSP2@142182|Gemmatimonadetes 142182|Gemmatimonadetes H Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) dxs - 2.2.1.7 ko:K01662 ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130 M00096 R05636 RC00032 ko00000,ko00001,ko00002,ko01000 - - - DXP_synthase_N,Transket_pyr,Transketolase_C k59_1181872_1 1265313.HRUBRA_00649 2.57e-62 201.0 COG1946@1|root,COG1946@2|Bacteria,1MV9R@1224|Proteobacteria 1224|Proteobacteria I Acyl-CoA thioesterase tesB GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006163,GO:0006629,GO:0006631,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009117,GO:0009150,GO:0009259,GO:0009987,GO:0016042,GO:0016054,GO:0016289,GO:0016787,GO:0016788,GO:0016790,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0033865,GO:0033875,GO:0034032,GO:0034641,GO:0035383,GO:0042802,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0046483,GO:0047617,GO:0051186,GO:0055086,GO:0071704,GO:0072329,GO:0072521,GO:1901135,GO:1901360,GO:1901564,GO:1901575 - ko:K10805 ko01040,map01040 - - - ko00000,ko00001,ko01000,ko01004 - - - 4HBT_3 k59_1411218_1 1100720.ALKN01000040_gene2175 1.07e-102 309.0 COG2873@1|root,COG2873@2|Bacteria,1NQME@1224|Proteobacteria,2VHYA@28216|Betaproteobacteria,4AACZ@80864|Comamonadaceae 28216|Betaproteobacteria E TIGRFAM O-acetylhomoserine O-acetylserine sulfhydrylase - - 2.5.1.49 ko:K01740 ko00270,ko01100,map00270,map01100 - R01287,R04859 RC00020,RC02821,RC02848 ko00000,ko00001,ko01000 - - - Cys_Met_Meta_PP k59_1689095_1 78245.Xaut_3982 2.6e-59 198.0 COG0845@1|root,COG0845@2|Bacteria,1MX8W@1224|Proteobacteria,2TRPM@28211|Alphaproteobacteria 28211|Alphaproteobacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - ko:K15727 - - - - ko00000,ko02000 8.A.1.2.1 - - Biotin_lipoyl_2,HlyD_D23 k59_394312_1 237368.SCABRO_01640 3.82e-21 92.4 COG3608@1|root,COG3608@2|Bacteria 237368.SCABRO_01640|- G succinylglutamate desuccinylase aspartoacylase - - - - - - - - - - - - - k59_394312_2 368407.Memar_0655 2.74e-44 160.0 COG0500@1|root,arCOG01791@2157|Archaea,2XZTQ@28890|Euryarchaeota,2NAGP@224756|Methanomicrobia 224756|Methanomicrobia Q Methyltransferase domain - - 6.3.2.4 ko:K01921 ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502 - R01150 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Dala_Dala_lig_C,Methyltransf_25 k59_221518_1 1114970.PSF113_5146 4.52e-30 118.0 COG0495@1|root,COG0495@2|Bacteria,1MV47@1224|Proteobacteria,1RP14@1236|Gammaproteobacteria,1YPHD@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria J due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm leuS GO:0003674,GO:0003824,GO:0004812,GO:0004823,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006429,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.4 ko:K01869 ko00970,map00970 M00359,M00360 R03657 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - iECOK1_1307.ECOK1_0652,iECS88_1305.ECS88_0684,iNRG857_1313.NRG857_02925,iPC815.YPO2610 Anticodon_1,tRNA-synt_1,tRNA-synt_1_2 k59_221518_2 595494.Tola_2721 2.13e-15 77.0 COG0815@1|root,COG0815@2|Bacteria,1MUBU@1224|Proteobacteria,1RM8M@1236|Gammaproteobacteria,1Y3M1@135624|Aeromonadales 135624|Aeromonadales M Transfers the fatty acyl group on membrane lipoproteins lnt - - ko:K03820 - - - - ko00000,ko01000 - GT2 - CN_hydrolase k59_1462221_1 1122137.AQXF01000001_gene2895 2.21e-99 297.0 COG0548@1|root,COG0548@2|Bacteria,1MU17@1224|Proteobacteria,2TQQS@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Belongs to the acetylglutamate kinase family. ArgB subfamily argB GO:0003674,GO:0003824,GO:0003991,GO:0005488,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016597,GO:0016740,GO:0016772,GO:0016774,GO:0019752,GO:0031406,GO:0034618,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.2.8 ko:K00930 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028 R02649 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase k59_1462221_2 1122137.AQXF01000001_gene2897 1.28e-72 231.0 COG5330@1|root,COG5330@2|Bacteria,1R4CF@1224|Proteobacteria,2TYQC@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Uncharacterised protein conserved in bacteria (DUF2336) - - - - - - - - - - - - DUF2336 k59_445241_1 1108045.GORHZ_106_00070 9.5e-29 112.0 COG1249@1|root,COG1249@2|Bacteria,2I6E8@201174|Actinobacteria 201174|Actinobacteria C Pyridine nucleotide-disulphide oxidoreductase - - - - - - - - - - - - - k59_445241_2 1122197.ATWI01000010_gene1088 4.98e-73 245.0 COG0243@1|root,COG0243@2|Bacteria,1NR6J@1224|Proteobacteria,1RMVE@1236|Gammaproteobacteria,46CKT@72275|Alteromonadaceae 1236|Gammaproteobacteria C Molybdopterin oxidoreductase bisC - - ko:K08351 ko00780,ko01100,map00780,map01100 - R10127 RC03056 ko00000,ko00001,ko01000,ko02000 5.A.3.4 - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding k59_115266_2 1121124.JNIX01000009_gene2943 2.88e-29 113.0 COG0620@1|root,COG0620@2|Bacteria,1MUI9@1224|Proteobacteria,2TTWK@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Methionine synthase - - 2.1.1.14 ko:K00549 ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230 M00017 R04405,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 - - - Meth_synt_2 k59_736649_1 861299.J421_3713 2.48e-81 262.0 COG0022@1|root,COG1071@1|root,COG0022@2|Bacteria,COG1071@2|Bacteria,1ZSQN@142182|Gemmatimonadetes 142182|Gemmatimonadetes C Transketolase, pyrimidine binding domain - - 1.2.4.4 ko:K11381 ko00280,ko00640,ko01100,ko01110,ko01130,map00280,map00640,map01100,map01110,map01130 M00036 R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997 RC00027,RC00627,RC02743,RC02883,RC02949,RC02953 br01601,ko00000,ko00001,ko00002,ko01000 - - - E1_dh,Transket_pyr,Transketolase_C k59_1019187_1 243090.RB9119 2.23e-80 257.0 COG2239@1|root,COG2239@2|Bacteria,2IYCZ@203682|Planctomycetes 203682|Planctomycetes P Acts as a magnesium transporter - - - ko:K06213 - - - - ko00000,ko02000 1.A.26.1 - - CBS,MgtE,MgtE_N k59_341210_1 1229909.NSED_00835 1.71e-16 78.2 COG2368@1|root,arCOG02143@2157|Archaea,41SA0@651137|Thaumarchaeota 651137|Thaumarchaeota Q Vinylacetyl-CoA Delta-isomerase - - 4.2.1.120,5.3.3.3 ko:K14534 ko00650,ko00720,ko01100,ko01120,ko01200,map00650,map00720,map01100,map01120,map01200 M00374,M00375 R03031,R10782 RC01857,RC03277 ko00000,ko00001,ko00002,ko01000 - - - HpaB,HpaB_N k59_341210_2 436308.Nmar_0206 2.31e-83 265.0 COG1042@1|root,arCOG01340@2157|Archaea,41S6N@651137|Thaumarchaeota 651137|Thaumarchaeota C Succinyl-CoA ligase like flavodoxin domain - - - ko:K18593 ko00720,ko01120,map00720,map01120 - R10758 RC00004,RC00014 ko00000,ko00001,ko01000 - - - ATP-grasp_5,CoA_binding_2,Succ_CoA_lig k59_227883_1 472759.Nhal_3449 6.55e-127 369.0 COG0057@1|root,COG0057@2|Bacteria,1MU93@1224|Proteobacteria,1RMBM@1236|Gammaproteobacteria,1WXC0@135613|Chromatiales 135613|Chromatiales G Belongs to the glyceraldehyde-3-phosphate dehydrogenase family gapA - 1.2.1.12 ko:K00134 ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01061 RC00149 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - Gp_dh_C,Gp_dh_N k59_171742_1 1163617.SCD_n00095 1.62e-132 390.0 COG0154@1|root,COG0154@2|Bacteria,1MUVQ@1224|Proteobacteria,2VIG3@28216|Betaproteobacteria 28216|Betaproteobacteria J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) gatA - 6.3.5.6,6.3.5.7 ko:K02433 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - Amidase k59_1188406_1 199310.c5222 3.73e-124 365.0 COG1027@1|root,COG1027@2|Bacteria,1R9JY@1224|Proteobacteria,1RP5Z@1236|Gammaproteobacteria,3XP1Y@561|Escherichia 1236|Gammaproteobacteria E Aspartate ammonia-lyase aspA GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006531,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008797,GO:0009058,GO:0009066,GO:0009893,GO:0009987,GO:0010468,GO:0010604,GO:0010628,GO:0010755,GO:0010756,GO:0010954,GO:0016053,GO:0016829,GO:0016840,GO:0016841,GO:0019222,GO:0019752,GO:0030162,GO:0031323,GO:0031325,GO:0032268,GO:0032270,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045862,GO:0046394,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060255,GO:0065007,GO:0070613,GO:0071704,GO:0080090,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1903317,GO:1903319 4.3.1.1 ko:K01744 ko00250,ko01100,map00250,map01100 - R00490 RC00316,RC02799 ko00000,ko00001,ko01000 - - iAPECO1_1312.APECO1_2250,iECs_1301.ECs5120,iG2583_1286.G2583_4966,iSBO_1134.SBO_4317,iSDY_1059.SDY_4444,iSF_1195.SF4293,iSFxv_1172.SFxv_4682,iSSON_1240.SSON_4322,iS_1188.S4560,iUTI89_1310.UTI89_C4736,iYL1228.KPN_04529,iZ_1308.Z5744,ic_1306.c5222 FumaraseC_C,Lyase_1 k59_567151_1 1129794.C427_1366 8.84e-41 160.0 COG0596@1|root,COG4206@1|root,COG0596@2|Bacteria,COG4206@2|Bacteria,1QVV2@1224|Proteobacteria,1T4JF@1236|Gammaproteobacteria 1236|Gammaproteobacteria H TonB dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_567151_3 1121033.AUCF01000005_gene5278 0.000117 47.8 COG0628@1|root,COG0628@2|Bacteria,1MXXU@1224|Proteobacteria,2TVPN@28211|Alphaproteobacteria,2JRFY@204441|Rhodospirillales 204441|Rhodospirillales S AI-2E family transporter - - - - - - - - - - - - AI-2E_transport k59_341229_1 555793.WSK_0753 1.78e-103 303.0 COG3201@1|root,COG3201@2|Bacteria,1RHIW@1224|Proteobacteria,2UC8W@28211|Alphaproteobacteria,2K45V@204457|Sphingomonadales 204457|Sphingomonadales H PFAM Nicotinamide mononucleotide transporter - - - ko:K03811 - - - - ko00000,ko02000 4.B.1.1 - - NMN_transporter k59_341229_2 555793.WSK_0754 1.36e-43 152.0 COG2334@1|root,COG2334@2|Bacteria,1R4QR@1224|Proteobacteria,2U6MC@28211|Alphaproteobacteria,2K2XX@204457|Sphingomonadales 204457|Sphingomonadales S Aminoglycoside phosphotransferase - - - - - - - - - - - - APH k59_1640433_1 34506.g6061 8.23e-24 100.0 2CZ9K@1|root,2S97H@2759|Eukaryota,399WY@33154|Opisthokonta,3CE13@33208|Metazoa,3DDDG@33213|Bilateria 33208|Metazoa S ECF sigma factor - - - - - - - - - - - - Sigma70_r2,Sigma70_r4_2 k59_58749_1 1229909.NSED_01410 5.3e-100 291.0 COG0456@1|root,arCOG00833@2157|Archaea,41SIY@651137|Thaumarchaeota 651137|Thaumarchaeota K FR47-like protein - - 2.3.1.128 ko:K03789 - - - - ko00000,ko01000,ko03009 - - - Acetyltransf_1 k59_453908_1 1233951.IO90_14370 1.11e-05 53.5 COG1629@1|root,COG4771@2|Bacteria,4PI4Z@976|Bacteroidetes,1IFYZ@117743|Flavobacteriia,3HJ42@358033|Chryseobacterium 976|Bacteroidetes P TonB dependent receptor - - - - - - - - - - - - Plug,TonB_dep_Rec k59_1131934_1 436308.Nmar_1630 1.22e-37 128.0 COG1545@1|root,arCOG01285@2157|Archaea,41SQK@651137|Thaumarchaeota 651137|Thaumarchaeota V nucleic-acid-binding protein containing a Zn-ribbon - - - ko:K07068 - - - - ko00000 - - - DUF35_N,OB_aCoA_assoc k59_1131934_2 1229909.NSED_08890 5.92e-78 242.0 COG0183@1|root,arCOG01278@2157|Archaea,41SCI@651137|Thaumarchaeota 651137|Thaumarchaeota I Thiolase, N-terminal domain - - 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N k59_1527402_1 436308.Nmar_0723 3.81e-13 72.8 arCOG08796@1|root,arCOG08796@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_1019218_1 1410613.JNKF01000012_gene1726 1.98e-53 191.0 COG3391@1|root,COG3391@2|Bacteria 2|Bacteria CO amine dehydrogenase activity - - - - - - - - - - - - Cupin_2,MRJP k59_397593_1 1150469.RSPPHO_02501 3.17e-147 435.0 COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,2TRKS@28211|Alphaproteobacteria,2JPS3@204441|Rhodospirillales 204441|Rhodospirillales I Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA acsA - 6.2.1.1 ko:K01895 ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200 M00357 R00235,R00236,R00316,R00926,R01354 RC00004,RC00012,RC00043,RC00070,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000,ko01004 - - - ACAS_N,AMP-binding,AMP-binding_C k59_171774_1 1122176.KB903537_gene1723 5.21e-52 182.0 COG3250@1|root,COG3250@2|Bacteria,4NESZ@976|Bacteroidetes,1IQAJ@117747|Sphingobacteriia 976|Bacteroidetes G Glycosyl hydrolases family 2, TIM barrel domain - - 3.2.1.31 ko:K01195 ko00040,ko00531,ko00860,ko00944,ko00983,ko01100,ko01110,ko04142,map00040,map00531,map00860,map00944,map00983,map01100,map01110,map04142 M00014,M00076,M00077,M00078,M00129 R01478,R04979,R07818,R08127,R08260,R10830 RC00055,RC00171,RC00529,RC00530,RC00714,RC01251 ko00000,ko00001,ko00002,ko01000 - - - Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N k59_1527407_1 1384054.N790_14220 1.43e-51 174.0 COG0491@1|root,COG0491@2|Bacteria,1P5NJ@1224|Proteobacteria,1S04Y@1236|Gammaproteobacteria,1XBW9@135614|Xanthomonadales 135614|Xanthomonadales S Metallo-beta-lactamase superfamily - - 3.5.2.6 ko:K17837 ko01501,map01501 - R06363 RC01499 ko00000,ko00001,ko01000 - - - Lactamase_B k59_905765_1 1449063.JMLS01000007_gene3403 3.58e-114 350.0 COG3408@1|root,COG3408@2|Bacteria,1U02P@1239|Firmicutes,4I9CQ@91061|Bacilli,271CA@186822|Paenibacillaceae 91061|Bacilli G Glycogen debranching enzyme - - - - - - - - - - - - - k59_962490_1 1237500.ANBA01000012_gene5237 3.37e-35 141.0 COG2770@1|root,COG5002@1|root,COG2770@2|Bacteria,COG5002@2|Bacteria,2GIX7@201174|Actinobacteria,4EHDZ@85012|Streptosporangiales 201174|Actinobacteria T His Kinase A (phosphoacceptor) domain - - 2.7.13.3 ko:K07642 ko02020,map02020 M00450,M00645,M00646,M00648 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,HisKA k59_1019222_1 1235803.C825_00159 5.11e-11 67.0 COG1629@1|root,COG1629@2|Bacteria,4NDXS@976|Bacteroidetes,2FM2D@200643|Bacteroidia 976|Bacteroidetes P TonB-linked outer membrane protein, SusC RagA family - - - - - - - - - - - - CarbopepD_reg_2,Plug,STN,TonB_dep_Rec k59_1019222_2 1123037.AUDE01000011_gene948 1.65e-23 98.2 COG5279@1|root,COG5279@2|Bacteria,4NKJ4@976|Bacteroidetes,1HZ5K@117743|Flavobacteriia 976|Bacteroidetes D Transglutaminase-like superfamily - - - - - - - - - - - - Transglut_core k59_115350_1 502025.Hoch_1919 2.51e-190 556.0 COG3808@1|root,COG3808@2|Bacteria,1MUQ3@1224|Proteobacteria,42N1H@68525|delta/epsilon subdivisions,2WJ0R@28221|Deltaproteobacteria,2YUGV@29|Myxococcales 28221|Deltaproteobacteria C Sodium pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for Na( ) movement across the membrane hppA - 3.6.1.1 ko:K15987 ko00190,map00190 - - - ko00000,ko00001,ko01000 3.A.10.1 - - H_PPase k59_793150_1 283699.D172_0839 7.03e-30 110.0 COG0802@1|root,COG0802@2|Bacteria,1RGYU@1224|Proteobacteria,1S6IB@1236|Gammaproteobacteria,2Q2G0@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria S ATPase or kinase yjeE GO:0000166,GO:0002949,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043531,GO:0044237,GO:0044238,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901363 - ko:K06925 - - - - ko00000,ko03016 - - - TsaE k59_1358015_1 1396418.BATQ01000141_gene3316 2.72e-64 215.0 COG0122@1|root,COG2169@1|root,COG0122@2|Bacteria,COG2169@2|Bacteria,46T20@74201|Verrucomicrobia,2IV2R@203494|Verrucomicrobiae 203494|Verrucomicrobiae L AlkA N-terminal domain - - - - - - - - - - - - Ada_Zn_binding,AlkA_N,HTH_18,HhH-GPD k59_567232_2 523791.Kkor_2556 2.91e-18 82.8 COG2834@1|root,COG2834@2|Bacteria,1MXW0@1224|Proteobacteria,1RS0K@1236|Gammaproteobacteria,1XHXM@135619|Oceanospirillales 135619|Oceanospirillales M Outer membrane lipoprotein-sorting protein - - - - - - - - - - - - LolA_like k59_906725_1 1127673.GLIP_2687 1.62e-79 263.0 COG1629@1|root,COG1629@2|Bacteria,1MV8W@1224|Proteobacteria,1RQEQ@1236|Gammaproteobacteria,463XU@72275|Alteromonadaceae 1236|Gammaproteobacteria P COG1629 Outer membrane receptor proteins, mostly Fe transport - - - - - - - - - - - - Plug,TonB_dep_Rec k59_1584807_1 1121923.GPUN_2881 1.72e-07 52.4 COG0778@1|root,COG0778@2|Bacteria,1RDTR@1224|Proteobacteria,1S0PS@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Nitroreductase family - - - - - - - - - - - - Nitroreductase k59_1584807_2 1158165.KB898879_gene2732 4.69e-38 142.0 COG2244@1|root,COG2244@2|Bacteria,1MUN5@1224|Proteobacteria,1RRAJ@1236|Gammaproteobacteria,1X0TU@135613|Chromatiales 135613|Chromatiales S Polysaccharide biosynthesis protein - - - - - - - - - - - - Polysacc_synt_C k59_1020351_1 485913.Krac_8572 5.2e-64 206.0 COG1131@1|root,COG1131@2|Bacteria,2G6HN@200795|Chloroflexi 200795|Chloroflexi V PFAM ABC transporter related - - - ko:K01990,ko:K16907 ko02010,map02010 M00224,M00254 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1 - - ABC_tran k59_342292_1 314285.KT71_18921 0.000104 50.1 COG4774@1|root,COG4774@2|Bacteria,1NMCN@1224|Proteobacteria,1RYC0@1236|Gammaproteobacteria,1J7WD@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M TonB dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_116447_1 1121396.KB893001_gene3992 5.34e-10 59.7 COG0457@1|root,COG4995@1|root,COG0457@2|Bacteria,COG4995@2|Bacteria,1MWRF@1224|Proteobacteria,42P9S@68525|delta/epsilon subdivisions,2WJI7@28221|Deltaproteobacteria 28221|Deltaproteobacteria KLT PFAM TPR repeat-containing protein - - - - - - - - - - - - TPR_10,TPR_12 k59_398612_1 237727.NAP1_02375 7.24e-78 252.0 COG0145@1|root,COG0145@2|Bacteria,1MU2Y@1224|Proteobacteria,2TQZ6@28211|Alphaproteobacteria,2K20D@204457|Sphingomonadales 204457|Sphingomonadales EQ PFAM Hydantoinase oxoprolinase - - 3.5.2.14 ko:K01473 ko00330,ko01100,map00330,map01100 - R03187 RC00632 ko00000,ko00001,ko01000 - - - Hydant_A_N,Hydantoinase_A k59_906743_1 264731.PRU_1102 3.34e-23 98.2 COG0148@1|root,COG0148@2|Bacteria,4NF5M@976|Bacteroidetes,2FMNI@200643|Bacteroidia 976|Bacteroidetes G Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis eno - 4.2.1.11 ko:K01689 ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066 M00001,M00002,M00003,M00346,M00394 R00658 RC00349 ko00000,ko00001,ko00002,ko01000,ko03019,ko04147 - - - Enolase_C,Enolase_N k59_906743_2 858619.CVAR_1100 4.14e-48 168.0 COG4559@1|root,COG4559@2|Bacteria,2GMUI@201174|Actinobacteria,22KQM@1653|Corynebacteriaceae 201174|Actinobacteria P ATPases associated with a variety of cellular activities hmuV - 3.6.3.34 ko:K02013 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.14 - - ABC_tran k59_172887_1 1121920.AUAU01000004_gene915 7.1e-09 58.5 COG2771@1|root,COG2771@2|Bacteria 2|Bacteria K luxR family - - - - - - - - - - - - GerE k59_680945_1 526222.Desal_2995 1.46e-06 49.7 COG0403@1|root,COG0403@2|Bacteria,1MVC1@1224|Proteobacteria,42MQ1@68525|delta/epsilon subdivisions,2WJII@28221|Deltaproteobacteria,2M9HZ@213115|Desulfovibrionales 28221|Deltaproteobacteria E The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor gcvPA - 1.4.4.2 ko:K00282 ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200 - R01221,R03425 RC00022,RC00929,RC02834,RC02880 ko00000,ko00001,ko01000 - - - GDC-P k59_680945_2 266117.Rxyl_3183 1.11e-41 141.0 COG0509@1|root,COG0509@2|Bacteria,2IKN2@201174|Actinobacteria,4CQGM@84995|Rubrobacteria 84995|Rubrobacteria E The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein gcvH - - ko:K02437 ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200 M00532 R01221 RC00022,RC02834 ko00000,ko00001,ko00002 - - - GCV_H k59_680945_3 1033732.CAHI01000002_gene2435 2.02e-09 59.7 COG0404@1|root,COG0404@2|Bacteria,4NF7S@976|Bacteroidetes,2FPDM@200643|Bacteroidia,22U1J@171550|Rikenellaceae 976|Bacteroidetes E The glycine cleavage system catalyzes the degradation of glycine gcvT - 2.1.2.10 ko:K00605 ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200 M00532 R01221,R02300,R04125 RC00022,RC00069,RC00183,RC02834 ko00000,ko00001,ko00002,ko01000 - - - GCV_T,GCV_T_C k59_737886_1 706587.Desti_0076 3.24e-37 140.0 COG0793@1|root,COG0793@2|Bacteria,1MU39@1224|Proteobacteria,42MHD@68525|delta/epsilon subdivisions,2WJKC@28221|Deltaproteobacteria,2MQ40@213462|Syntrophobacterales 28221|Deltaproteobacteria M PDZ domain (Also known as DHR or GLGF) ctpA - 3.4.21.102 ko:K03797 - - - - ko00000,ko01000,ko01002 - - - PDZ,PDZ_2,Peptidase_S41 k59_1302631_1 316407.1651236 2.71e-105 330.0 COG4783@1|root,COG4783@2|Bacteria,1N6EA@1224|Proteobacteria,1T2BB@1236|Gammaproteobacteria,3XPEU@561|Escherichia 1236|Gammaproteobacteria M Bacteriophage N4 adsorption protein A nfrA GO:0005575,GO:0005623,GO:0009279,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0044462,GO:0044464,GO:0071944 - ko:K11739 - - - - ko00000 - - - NfrA_C,TPR_15,TPR_19 k59_285800_1 314287.GB2207_08756 5.11e-144 412.0 COG0224@1|root,COG0224@2|Bacteria,1MU28@1224|Proteobacteria,1RNWJ@1236|Gammaproteobacteria,1J4Q3@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex atpG GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0036442,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045261,GO:0045262,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0046961,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - ko:K02115 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - iSSON_1240.SSON_3886,iYL1228.KPN_04138 ATP-synt k59_1697912_1 1122194.AUHU01000002_gene2774 2.28e-38 146.0 COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,1RMZ8@1236|Gammaproteobacteria,46AAE@72275|Alteromonadaceae 1236|Gammaproteobacteria I 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain yfcX - 1.1.1.35,4.2.1.17,5.1.2.3 ko:K01782 ko00071,ko00280,ko00281,ko00310,ko00362,ko00380,ko00410,ko00640,ko00650,ko00903,ko00930,ko01040,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00362,map00380,map00410,map00640,map00650,map00903,map00930,map01040,map01100,map01110,map01120,map01130,map01200,map01212 M00032,M00087 R01975,R03026,R03045,R03276,R04137,R04170,R04203,R04204,R04224,R04737,R04738,R04739,R04740,R04741,R04744,R04745,R04746,R04748,R04749,R05066,R05305,R06411,R06412,R06941,R06942,R07935,R07951,R08093,R08094 RC00029,RC00099,RC00117,RC00241,RC00525,RC00831,RC00834,RC00896,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 - - - 3HCDH,3HCDH_N,ECH_1 k59_1641560_1 926560.KE387023_gene3760 2.94e-05 50.1 COG2133@1|root,COG2133@2|Bacteria 2|Bacteria G pyrroloquinoline quinone binding - - - - - - - - - - - - CHRD,Malectin k59_342323_1 1318628.MARLIPOL_04615 2.35e-138 407.0 COG1055@1|root,COG1055@2|Bacteria,1MUH8@1224|Proteobacteria,1RPSM@1236|Gammaproteobacteria,465Z4@72275|Alteromonadaceae 1236|Gammaproteobacteria P COG1055 Na H antiporter NhaD and related arsenite permeases nhaD - - - - - - - - - - - CitMHS k59_3099_1 1232410.KI421426_gene1372 1.13e-85 278.0 COG1554@1|root,COG1554@2|Bacteria,1MWJE@1224|Proteobacteria,42Q4Z@68525|delta/epsilon subdivisions,2WM28@28221|Deltaproteobacteria 28221|Deltaproteobacteria G PFAM Glycoside hydrolase family 65, central catalytic - - - - - - - - - - - - Glyco_hydro_65C,Glyco_hydro_65N,Glyco_hydro_65m,HAD_2,Hydrolase k59_511463_1 177439.DP1352 1.03e-40 147.0 COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,42MC0@68525|delta/epsilon subdivisions,2WKD9@28221|Deltaproteobacteria,2MMGP@213118|Desulfobacterales 28221|Deltaproteobacteria P ABC transporter - - 3.6.3.29 ko:K02017 ko02010,map02010 M00189 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.8 - - ABC_tran k59_1302649_1 1301098.PKB_0152 1.23e-52 177.0 COG1216@1|root,COG1216@2|Bacteria,1RBVM@1224|Proteobacteria,1S2YU@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Glycosyl transferase family 2 - - - - - - - - - - - - Glycos_transf_2 k59_963447_1 203122.Sde_2382 2.84e-38 142.0 COG0204@1|root,COG0204@2|Bacteria,1MUFH@1224|Proteobacteria,1RNJQ@1236|Gammaproteobacteria,465A9@72275|Alteromonadaceae 1236|Gammaproteobacteria I Phosphate acyltransferases - - - - - - - - - - - - Acyltransferase k59_398661_2 582744.Msip34_0648 4.49e-21 94.0 COG0031@1|root,COG0031@2|Bacteria,1MUBE@1224|Proteobacteria,2VJI3@28216|Betaproteobacteria,2KMBQ@206350|Nitrosomonadales 206350|Nitrosomonadales E Belongs to the cysteine synthase cystathionine beta- synthase family - - 2.5.1.47 ko:K01738 ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230 M00021 R00897,R03601,R04859 RC00020,RC02814,RC02821 ko00000,ko00001,ko00002,ko01000 - - - PALP k59_342338_1 1380600.AUYN01000003_gene27 7.55e-123 357.0 COG4152@1|root,COG4152@2|Bacteria,4NEJE@976|Bacteroidetes,1HXY0@117743|Flavobacteriia 976|Bacteroidetes S abc transporter (atp-binding protein) natA - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran,DUF4162 k59_680967_1 396588.Tgr7_1236 2.54e-08 56.6 COG2890@1|root,COG2890@2|Bacteria,1MX8Q@1224|Proteobacteria,1RPHQ@1236|Gammaproteobacteria,1WWX2@135613|Chromatiales 135613|Chromatiales J Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue prmB - 2.1.1.298 ko:K07320 - - R10806 RC00003,RC03279 ko00000,ko01000,ko03009 - - - MTS k59_680967_2 4432.XP_010255751.1 6.76e-22 97.4 COG1999@1|root,KOG2792@2759|Eukaryota,37M1T@33090|Viridiplantae,3G73D@35493|Streptophyta 35493|Streptophyta C Protein SCO1 homolog 1 - GO:0000003,GO:0003006,GO:0003674,GO:0005488,GO:0005507,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0006996,GO:0007005,GO:0007275,GO:0008150,GO:0008535,GO:0009790,GO:0009791,GO:0009793,GO:0009987,GO:0010154,GO:0016043,GO:0017004,GO:0022414,GO:0022607,GO:0032501,GO:0032502,GO:0033108,GO:0033617,GO:0034622,GO:0043167,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043933,GO:0044085,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0048316,GO:0048608,GO:0048731,GO:0048856,GO:0061458,GO:0065003,GO:0071840 - ko:K07152 - - - - ko00000,ko03029 - - - SCO1-SenC k59_850656_2 349124.Hhal_0246 3.63e-64 208.0 COG3752@1|root,COG3752@2|Bacteria,1MXCP@1224|Proteobacteria,1RQID@1236|Gammaproteobacteria,1WXW3@135613|Chromatiales 135613|Chromatiales S 3-oxo-5-alpha-steroid 4-dehydrogenase - - - - - - - - - - - - DUF1295 k59_850656_3 883080.HMPREF9697_02440 1.16e-11 66.6 COG3496@1|root,COG3496@2|Bacteria,1RC56@1224|Proteobacteria,2TUX0@28211|Alphaproteobacteria,3JX7V@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S Protein of unknown function (DUF1365) - - - ko:K09701 - - - - ko00000 - - - DUF1365 k59_624529_1 452637.Oter_3368 5.04e-61 203.0 COG0147@1|root,COG0147@2|Bacteria,46S4I@74201|Verrucomicrobia,3K72I@414999|Opitutae 414999|Opitutae EH Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia trpE - 4.1.3.27 ko:K01657 ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025 M00023 R00985,R00986 RC00010,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 - - - Anth_synt_I_N,Chorismate_bind k59_794267_1 105422.BBPM01000084_gene7302 1.33e-05 50.8 COG1846@1|root,COG1846@2|Bacteria,2HR0N@201174|Actinobacteria,2NN73@228398|Streptacidiphilus 201174|Actinobacteria K helix_turn_helix multiple antibiotic resistance protein - - - - - - - - - - - - - k59_1472039_1 1380354.JIAN01000007_gene389 8.04e-51 174.0 COG0500@1|root,COG0500@2|Bacteria,2I3GX@201174|Actinobacteria 201174|Actinobacteria Q methyltransferase - - - - - - - - - - - - Methyltransf_31 k59_59950_1 1122225.AULQ01000002_gene722 2.21e-29 115.0 COG1541@1|root,COG1541@2|Bacteria,4PKJA@976|Bacteroidetes,1IJAQ@117743|Flavobacteriia 976|Bacteroidetes H GH3 auxin-responsive promoter - - - - - - - - - - - - GH3 k59_59950_2 1178825.ALIH01000009_gene1296 2.19e-129 372.0 COG0739@1|root,COG0739@2|Bacteria,4NFZN@976|Bacteroidetes,1HXBC@117743|Flavobacteriia 976|Bacteroidetes M peptidase nlpD_1 - - - - - - - - - - - Peptidase_M23 k59_737933_2 94122.Shewana3_1527 2.28e-16 77.4 COG1943@1|root,COG1943@2|Bacteria,1RAP9@1224|Proteobacteria,1S230@1236|Gammaproteobacteria,2QESI@267890|Shewanellaceae 1236|Gammaproteobacteria L Transposase IS200 like - - - ko:K07491 - - - - ko00000 - - - Y1_Tnp k59_1641586_1 402626.Rpic_4973 1.6e-76 234.0 COG4422@1|root,COG4422@2|Bacteria,1MXQI@1224|Proteobacteria,2VJP8@28216|Betaproteobacteria,1K05N@119060|Burkholderiaceae 28216|Betaproteobacteria S PFAM Gp37Gp68 family protein - - - - - - - - - - - - DUF5131 k59_1584862_1 1323663.AROI01000004_gene2086 9.81e-11 69.7 COG0642@1|root,COG0784@1|root,COG0784@2|Bacteria,COG2205@2|Bacteria,1R9DM@1224|Proteobacteria,1S0EG@1236|Gammaproteobacteria 1236|Gammaproteobacteria T Histidine kinase retS - - ko:K20972 ko02025,map02025 - - - ko00000,ko00001,ko01001,ko02022 - - - 7TMR-DISMED2,7TMR-DISM_7TM,HATPase_c,HisKA,Response_reg k59_1647245_1 715226.ABI_01780 7.01e-12 76.6 COG4625@1|root,COG4625@2|Bacteria,1N4H5@1224|Proteobacteria,2TT5A@28211|Alphaproteobacteria 28211|Alphaproteobacteria S outer membrane autotransporter barrel - - - - - - - - - - - - Autotransporter k59_1759832_1 436308.Nmar_0308 3.24e-45 147.0 COG2146@1|root,arCOG02852@2157|Archaea,41SSE@651137|Thaumarchaeota 651137|Thaumarchaeota P Rieske 2Fe-2S - - - ko:K05710 ko00360,ko01120,ko01220,map00360,map01120,map01220 M00545 R06782,R06783 RC00098 br01602,ko00000,ko00001,ko00002 - - - Rieske k59_1759832_2 436308.Nmar_0307 5.89e-45 146.0 COG1698@1|root,arCOG04308@2157|Archaea,41SRP@651137|Thaumarchaeota 651137|Thaumarchaeota S Belongs to the UPF0147 family - - - ko:K09721 - - - - ko00000 - - - UPF0147 k59_9040_1 190650.CC_1099 1.21e-33 135.0 COG1629@1|root,COG1629@2|Bacteria,COG4771@2|Bacteria,1MU9K@1224|Proteobacteria,2U0AK@28211|Alphaproteobacteria,2KG7W@204458|Caulobacterales 204458|Caulobacterales P TonB-dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_1308097_2 436308.Nmar_1782 7.09e-84 262.0 COG1746@1|root,arCOG04249@2157|Archaea,41S76@651137|Thaumarchaeota 651137|Thaumarchaeota J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate cca - 2.7.7.72 ko:K07558 - - R09382,R09383,R09384,R09386 RC00078 ko00000,ko01000,ko03016 - - - NTP_transf_2,tRNA_NucTransf2 k59_403936_1 1229909.NSED_00180 6e-39 145.0 COG0443@1|root,arCOG03060@2157|Archaea,41SCM@651137|Thaumarchaeota 651137|Thaumarchaeota O Heat shock 70 kDa protein dnaK - - ko:K04043 ko03018,ko04212,ko05152,map03018,map04212,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 1.A.33.1 - - HSP70 k59_1194901_1 292415.Tbd_0710 1.07e-44 158.0 28KDQ@1|root,2ZA05@2|Bacteria,1QVCG@1224|Proteobacteria,2VTD9@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_743147_1 1127673.GLIP_2928 1.31e-08 58.2 COG0823@1|root,COG0823@2|Bacteria,1R3VN@1224|Proteobacteria,1RNKG@1236|Gammaproteobacteria,46408@72275|Alteromonadaceae 1236|Gammaproteobacteria U COG0823 Periplasmic component of the Tol biopolymer transport system - - - - - - - - - - - - PD40 k59_629930_2 477184.KYC_19569 1.58e-11 69.3 COG4773@1|root,COG4773@2|Bacteria,1MW5E@1224|Proteobacteria,2VHUH@28216|Betaproteobacteria 28216|Betaproteobacteria P COG1629 Outer membrane receptor proteins, mostly Fe transport - - - - - - - - - - - - Plug,STN,TonB_dep_Rec k59_1477964_1 1279017.AQYJ01000020_gene1353 2.16e-61 192.0 COG0359@1|root,COG0359@2|Bacteria,1RD0R@1224|Proteobacteria,1S3WS@1236|Gammaproteobacteria,466HW@72275|Alteromonadaceae 1236|Gammaproteobacteria J Binds to the 23S rRNA rplI GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070180,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02939 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L9_C,Ribosomal_L9_N k59_1138303_1 1121022.ABENE_21490 4.3e-75 241.0 COG2303@1|root,COG2303@2|Bacteria,1MU3F@1224|Proteobacteria,2TT3C@28211|Alphaproteobacteria,2KFW2@204458|Caulobacterales 204458|Caulobacterales E Oxidoreductase - - - - - - - - - - - - GMC_oxred_C,GMC_oxred_N k59_1703232_1 351348.Maqu_0490 5.07e-189 536.0 COG0165@1|root,COG0165@2|Bacteria,1MUTU@1224|Proteobacteria,1RMA3@1236|Gammaproteobacteria,4644I@72275|Alteromonadaceae 1236|Gammaproteobacteria E argininosuccinate lyase argH GO:0003674,GO:0003824,GO:0004056,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016829,GO:0016840,GO:0016842,GO:0019752,GO:0042450,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.3.2.1 ko:K01755 ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230 M00029,M00844,M00845 R01086 RC00445,RC00447 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ASL_C2,Lyase_1 k59_629957_1 436308.Nmar_0224 4.56e-134 392.0 COG1109@1|root,arCOG00767@2157|Archaea,41S74@651137|Thaumarchaeota 651137|Thaumarchaeota G Belongs to the phosphohexose mutase family - - 5.4.2.2,5.4.2.8 ko:K15778 ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130 M00114 R00959,R01057,R01818,R08639 RC00408 ko00000,ko00001,ko00002,ko01000 - - - PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV k59_65807_1 313606.M23134_07778 4.91e-10 65.5 COG0577@1|root,COG0577@2|Bacteria,4NDUK@976|Bacteroidetes,47JJN@768503|Cytophagia 976|Bacteroidetes V FtsX-like permease family - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_968769_1 1316936.K678_09136 1.46e-62 206.0 COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,2TQQ7@28211|Alphaproteobacteria,2JQYB@204441|Rhodospirillales 204441|Rhodospirillales I Belongs to the thiolase family atoB - 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N k59_1308147_1 349161.Dred_3323 1.81e-28 117.0 COG0445@1|root,COG0445@2|Bacteria,1TQ4B@1239|Firmicutes,247U2@186801|Clostridia,2601R@186807|Peptococcaceae 186801|Clostridia D NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 gidA - - ko:K03495 - - R08701 RC00053,RC00209,RC00870 ko00000,ko03016,ko03036 - - - GIDA,GIDA_assoc k59_1027172_1 997346.HMPREF9374_2823 9.31e-30 119.0 COG0085@1|root,COG0085@2|Bacteria,1TP96@1239|Firmicutes,4H9PK@91061|Bacilli,27B15@186824|Thermoactinomycetaceae 91061|Bacilli K RNA polymerase Rpb2, domain 3 rpoB GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234 2.7.7.6 ko:K03043 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7 k59_1139224_1 1217718.ALOU01000112_gene4316 4.65e-131 385.0 COG1075@1|root,COG1075@2|Bacteria,1NSK3@1224|Proteobacteria,2WG1G@28216|Betaproteobacteria,1KI8H@119060|Burkholderiaceae 28216|Betaproteobacteria S acetyltransferases and hydrolases with the alpha beta hydrolase fold - - - - - - - - - - - - - k59_66575_1 1121033.AUCF01000013_gene1597 1.6e-93 293.0 COG1884@1|root,COG2185@1|root,COG1884@2|Bacteria,COG2185@2|Bacteria,1MUXX@1224|Proteobacteria,2TQYC@28211|Alphaproteobacteria,2JP9C@204441|Rhodospirillales 204441|Rhodospirillales I Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly icmF - 5.4.99.2 ko:K01847 ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200 M00373,M00376,M00741 R00833 RC00395 ko00000,ko00001,ko00002,ko01000 - - - ArgK,B12-binding,MM_CoA_mutase k59_630814_1 1137281.D778_01034 6.49e-97 293.0 COG5434@1|root,COG5434@2|Bacteria,4NFZJ@976|Bacteroidetes,1HZP4@117743|Flavobacteriia 976|Bacteroidetes M Large extracellular alpha-helical protein - - - - - - - - - - - - PSCyt1,fn3 k59_687327_1 2340.JV46_19000 1.31e-59 191.0 COG3467@1|root,COG3467@2|Bacteria,1MWQE@1224|Proteobacteria,1S4WW@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Pyridoxamine 5'-phosphate oxidase - - - ko:K07005 - - - - ko00000 - - - Pyridox_ox_2 k59_687327_2 555500.I215_10735 1.45e-06 48.9 COG0263@1|root,COG0263@2|Bacteria,4NH75@976|Bacteroidetes,1HXDB@117743|Flavobacteriia 976|Bacteroidetes E Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate proB - 2.7.2.11 ko:K00931 ko00330,ko00332,ko01100,ko01130,ko01230,map00330,map00332,map01100,map01130,map01230 M00015 R00239 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase,PUA k59_857405_1 384765.SIAM614_23102 2.98e-38 136.0 COG2761@1|root,COG2761@2|Bacteria,1NXUB@1224|Proteobacteria,2U1PN@28211|Alphaproteobacteria 28211|Alphaproteobacteria Q dithiol-disulfide isomerase involved in polyketide biosynthesis - - - - - - - - - - - - DSBA k59_1704161_1 1207063.P24_08539 1.41e-53 182.0 COG0477@1|root,COG2814@2|Bacteria,1MW19@1224|Proteobacteria,2TRQD@28211|Alphaproteobacteria,2JPV2@204441|Rhodospirillales 204441|Rhodospirillales EGP Sugar (and other) transporter - - - ko:K07552 - - - - ko00000,ko02000 2.A.1.2 - - MFS_1 k59_744012_1 870187.Thini_3341 5.24e-108 329.0 COG0445@1|root,COG0445@2|Bacteria,1MU6F@1224|Proteobacteria,1RMM1@1236|Gammaproteobacteria,4604K@72273|Thiotrichales 72273|Thiotrichales D NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 gidA - - ko:K03495 - - R08701 RC00053,RC00209,RC00870 ko00000,ko03016,ko03036 - - - GIDA,GIDA_assoc k59_1365621_1 1347342.BN863_33000 9.22e-83 268.0 COG4772@1|root,COG4772@2|Bacteria,4NEJW@976|Bacteroidetes,1HWWZ@117743|Flavobacteriia 976|Bacteroidetes P TonB-dependent receptor - - - - - - - - - - - - CarbopepD_reg_2,Plug,TonB_dep_Rec k59_1704172_1 1117647.M5M_14385 3.09e-70 227.0 COG0301@1|root,COG0607@1|root,COG0301@2|Bacteria,COG0607@2|Bacteria,1MWD3@1224|Proteobacteria,1RNZT@1236|Gammaproteobacteria,1J5HG@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria HP Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS thiI GO:0000049,GO:0002937,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0017144,GO:0018130,GO:0019438,GO:0034227,GO:0034470,GO:0034641,GO:0034660,GO:0042364,GO:0042723,GO:0042724,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:0090304,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.8.1.4 ko:K03151 ko00730,ko01100,ko04122,map00730,map01100,map04122 - R07461 - ko00000,ko00001,ko01000,ko03016 - - iECNA114_1301.ECNA114_0400,iECO26_1355.ECO26_0455,iECSF_1327.ECSF_0383,iSDY_1059.SDY_0307 THUMP,ThiI k59_913442_1 391587.KAOT1_09566 7.16e-47 165.0 COG0296@1|root,COG0296@2|Bacteria,4NECZ@976|Bacteroidetes,1HXCC@117743|Flavobacteriia 976|Bacteroidetes G Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position glgB - 2.4.1.18 ko:K00700 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R02110 - ko00000,ko00001,ko00002,ko01000,ko04147 - CBM48,GH13 - Alpha-amylase,Alpha-amylase_C,CBM_48 k59_913442_2 391587.KAOT1_09571 5.32e-52 178.0 COG3281@1|root,COG3281@2|Bacteria,4PMAP@976|Bacteroidetes,1HZME@117743|Flavobacteriia 976|Bacteroidetes G Trehalose synthase - - 3.2.1.1,5.4.99.16 ko:K05343 ko00500,ko01100,map00500,map01100 - R01557,R02108,R02112,R11262 RC01816 ko00000,ko00001,ko01000 - GH13 - APH k59_292504_1 1203611.KB894549_gene2294 1.63e-29 112.0 COG0218@1|root,COG0218@2|Bacteria,4NEA9@976|Bacteroidetes,2FM4M@200643|Bacteroidia,22UZE@171550|Rikenellaceae 976|Bacteroidetes D Necessary for normal cell division and for the maintenance of normal septation engB GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - ko:K03978 - - - - ko00000,ko03036 - - - MMR_HSR1 k59_461432_1 401526.TcarDRAFT_1088 3.23e-47 167.0 COG1055@1|root,COG1055@2|Bacteria,1TPNN@1239|Firmicutes,4H2F8@909932|Negativicutes 909932|Negativicutes P Citrate transporter - - - - - - - - - - - - CitMHS k59_1760816_2 436308.Nmar_0692 7.97e-98 296.0 COG0624@1|root,arCOG01110@2157|Archaea,41SAE@651137|Thaumarchaeota 651137|Thaumarchaeota E Peptidase dimerisation domain - - - - - - - - - - - - M20_dimer,Peptidase_M20 k59_1082916_1 221288.JH992901_gene4388 2.76e-64 204.0 COG1028@1|root,COG1028@2|Bacteria,1G4JP@1117|Cyanobacteria,1JIJE@1189|Stigonemataceae 1117|Cyanobacteria IQ Enoyl-(Acyl carrier protein) reductase - - - - - - - - - - - - adh_short k59_1139263_1 377629.TERTU_3065 5.33e-79 257.0 COG0038@1|root,COG0038@2|Bacteria,1MV4K@1224|Proteobacteria,1RQJW@1236|Gammaproteobacteria,2PPTP@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria P Voltage gated chloride channel eriC - - ko:K03281 - - - - ko00000 2.A.49 - - Voltage_CLC k59_1027216_1 203122.Sde_3173 3.74e-51 173.0 COG0530@1|root,COG0530@2|Bacteria,1MU3R@1224|Proteobacteria,1RMRD@1236|Gammaproteobacteria,464C7@72275|Alteromonadaceae 1236|Gammaproteobacteria P COG0530 Ca2 Na antiporter yrbG - - ko:K07301 - - - - ko00000,ko02000 2.A.19.5 - - Na_Ca_ex k59_235264_1 316407.85675334 2.41e-99 298.0 COG5160@1|root,COG5160@2|Bacteria,1N09I@1224|Proteobacteria,1SC0W@1236|Gammaproteobacteria 1236|Gammaproteobacteria O Protease that can act as an efficient and specific deubiquitinating enzyme in vitro. Does not possess desumoylating and deneddylating activities. The physiological substrate is elaD GO:0003674,GO:0003824,GO:0006464,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008234,GO:0009987,GO:0016579,GO:0016787,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0070011,GO:0070646,GO:0070647,GO:0071704,GO:0140096,GO:1901564 - ko:K18015 - - - - ko00000,ko01000,ko01002 - - - Peptidase_C48 k59_461447_1 857087.Metme_3049 3.69e-99 310.0 COG0542@1|root,COG0542@2|Bacteria,1MV8B@1224|Proteobacteria,1RMH3@1236|Gammaproteobacteria,1XEC1@135618|Methylococcales 135618|Methylococcales O ATP-dependent Clp protease, ATP-binding subunit ClpA clpA - - ko:K03694 - - - - ko00000,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N k59_1760829_1 745014.OMB55_00020030 5.62e-26 106.0 COG2175@1|root,COG2175@2|Bacteria,1P6UZ@1224|Proteobacteria,1T14G@1236|Gammaproteobacteria 1236|Gammaproteobacteria Q Taurine catabolism dioxygenase TauD, TfdA family - - 1.14.11.17 ko:K03119 ko00430,ko00920,map00430,map00920 - R05320 RC01331 ko00000,ko00001,ko01000 - - - TauD k59_1760829_2 990285.RGCCGE502_03052 2.2e-39 147.0 COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,2TQSC@28211|Alphaproteobacteria,4B7HD@82115|Rhizobiaceae 28211|Alphaproteobacteria L DNA helicase uvrD - 3.6.4.12 ko:K03657 ko03420,ko03430,map03420,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - UvrD-helicase,UvrD_C k59_348987_2 243230.DR_0428 7.44e-23 94.0 COG3695@1|root,COG3695@2|Bacteria 2|Bacteria L enzyme binding ogt - 2.1.1.63 ko:K00567,ko:K07443 - - - - ko00000,ko01000,ko03400 - - - DNA_binding_1,YjbR k59_348987_4 391038.Bphy_4828 9.88e-58 195.0 COG2025@1|root,COG2025@2|Bacteria,1MUFI@1224|Proteobacteria,2VI6W@28216|Betaproteobacteria,1K1EZ@119060|Burkholderiaceae 28216|Betaproteobacteria C Electron transfer flavoprotein etfA - - ko:K03522 - - - - ko00000,ko04147 - - - ETF,ETF_alpha k59_1704205_2 1550073.JROH01000016_gene339 6.06e-64 208.0 COG2271@1|root,COG2271@2|Bacteria,1MV04@1224|Proteobacteria,2U253@28211|Alphaproteobacteria,2K1NR@204457|Sphingomonadales 204457|Sphingomonadales G Major Facilitator Superfamily - - - ko:K08191 - - - - ko00000,ko02000 2.A.1.14.2 - - MFS_1 k59_1535004_1 1187851.A33M_1394 4.83e-92 278.0 COG0673@1|root,COG0673@2|Bacteria,1MUP0@1224|Proteobacteria,2TT57@28211|Alphaproteobacteria 28211|Alphaproteobacteria S oxidoreductase - - - - - - - - - - - - GFO_IDH_MocA,GFO_IDH_MocA_C k59_348992_1 1009370.ALO_19177 1.24e-12 72.4 COG2271@1|root,COG2271@2|Bacteria,1TRHT@1239|Firmicutes,4H66F@909932|Negativicutes 909932|Negativicutes G Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 k59_1082944_1 414684.RC1_2806 2.78e-65 218.0 COG1331@1|root,COG1331@2|Bacteria,1MUUT@1224|Proteobacteria,2TV0X@28211|Alphaproteobacteria,2JPU1@204441|Rhodospirillales 204441|Rhodospirillales O COG1331 Highly conserved protein containing a thioredoxin domain - - - ko:K06888 - - - - ko00000 - - - GlcNAc_2-epim,Thioredox_DsbH k59_1648044_1 1158338.JNLJ01000001_gene338 3.48e-19 91.3 COG2204@1|root,COG2204@2|Bacteria,2G3R2@200783|Aquificae 200783|Aquificae T Bacterial regulatory protein, Fis family - - - ko:K02667 ko02020,map02020 M00501 - - ko00000,ko00001,ko00002,ko02022,ko02035 - - - HTH_8,Response_reg,Sigma54_activat k59_574373_1 436308.Nmar_1743 2.94e-47 157.0 arCOG10601@1|root,arCOG10601@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_857497_1 555793.WSK_2094 1.33e-21 90.1 COG0745@1|root,COG0745@2|Bacteria,1MY3D@1224|Proteobacteria,2TTKG@28211|Alphaproteobacteria,2K0YQ@204457|Sphingomonadales 204457|Sphingomonadales T COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain - - - ko:K02483 - - - - ko00000,ko02022 - - - Response_reg,Trans_reg_C k59_857497_2 555793.WSK_2093 1.11e-98 305.0 COG0642@1|root,COG2205@2|Bacteria,1MUAK@1224|Proteobacteria,2TSUC@28211|Alphaproteobacteria,2JZUS@204457|Sphingomonadales 204457|Sphingomonadales T Histidine kinase - - - - - - - - - - - - HAMP,HATPase_c,HisKA k59_1195945_1 338963.Pcar_2344 2.02e-38 146.0 COG5000@1|root,COG5000@2|Bacteria,1MWKZ@1224|Proteobacteria,42MCN@68525|delta/epsilon subdivisions,2WIYA@28221|Deltaproteobacteria,43SDF@69541|Desulfuromonadales 28221|Deltaproteobacteria T PAS domain ntrY - 2.7.13.3 ko:K13598 ko02020,map02020 M00498 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,HisKA,PAS,PAS_4 k59_1760868_1 531844.FIC_00978 6.82e-33 118.0 COG2764@1|root,COG2764@2|Bacteria,4NQD7@976|Bacteroidetes,1I2C0@117743|Flavobacteriia 976|Bacteroidetes S glyoxalase - - - ko:K04750 - - - - ko00000 - - - 3-dmu-9_3-mt k59_969550_1 393595.ABO_1607 5.16e-64 206.0 COG1075@1|root,COG1075@2|Bacteria,1N2W0@1224|Proteobacteria,1S2JW@1236|Gammaproteobacteria,1XP3H@135619|Oceanospirillales 135619|Oceanospirillales S acetyltransferases and hydrolases with the alpha beta hydrolase fold - - - - - - - - - - - - - k59_235291_1 172088.AUGA01000099_gene4527 1.29e-105 321.0 COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2TQR1@28211|Alphaproteobacteria,3JVNS@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria C Aldehyde dehydrogenase family - - - - - - - - - - - - Aldedh k59_1195946_2 1122137.AQXF01000003_gene2201 1.32e-86 260.0 COG1309@1|root,COG1309@2|Bacteria,1N3KN@1224|Proteobacteria,2UI3H@28211|Alphaproteobacteria 28211|Alphaproteobacteria K Bacterial regulatory proteins, tetR family - - - - - - - - - - - - TetR_N k59_1139325_1 1415778.JQMM01000001_gene24 1.38e-63 201.0 COG0741@1|root,COG0741@2|Bacteria,1R666@1224|Proteobacteria,1S3XT@1236|Gammaproteobacteria,1J644@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains) - - - - - - - - - - - - SLT k59_1535032_1 1122137.AQXF01000001_gene2929 9.1e-142 410.0 COG0161@1|root,COG0161@2|Bacteria,1MU2N@1224|Proteobacteria,2TQND@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family bioA - 2.6.1.62 ko:K00833 ko00780,ko01100,map00780,map01100 M00123,M00573,M00577 R03231 RC00006,RC00887 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 k59_179000_1 436308.Nmar_1316 2.49e-102 306.0 COG0477@1|root,arCOG00130@2157|Archaea,41T0X@651137|Thaumarchaeota 651137|Thaumarchaeota G major facilitator superfamily - - - ko:K08153,ko:K08221 - M00717 - - ko00000,ko00002,ko02000 2.A.1.2.8,2.A.1.32 - - MFS_1 k59_969557_1 1122137.AQXF01000004_gene1599 2.08e-170 498.0 COG0187@1|root,COG0187@2|Bacteria,1MVKT@1224|Proteobacteria,2TRBK@28211|Alphaproteobacteria 28211|Alphaproteobacteria L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrB - 5.99.1.3 ko:K02470 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim k59_1365715_1 926569.ANT_10570 7.4e-77 250.0 COG1185@1|root,COG1185@2|Bacteria,2G5TS@200795|Chloroflexi 200795|Chloroflexi J Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction pnp GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004654,GO:0005488,GO:0006139,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009892,GO:0009987,GO:0010468,GO:0010605,GO:0010629,GO:0016070,GO:0016071,GO:0016740,GO:0016772,GO:0016779,GO:0019222,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0060255,GO:0065007,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901361,GO:1901363,GO:1901575 2.7.7.8 ko:K00962 ko00230,ko00240,ko03018,map00230,map00240,map03018 M00394 R00437,R00438,R00439,R00440 RC02795 ko00000,ko00001,ko00002,ko01000,ko03016,ko03019 - - - KH_1,PNPase,RNase_PH,RNase_PH_C,S1 k59_517724_1 316407.85677099 2.71e-174 505.0 COG1368@1|root,COG1368@2|Bacteria,1MVCM@1224|Proteobacteria,1RNJ3@1236|Gammaproteobacteria,3XP4B@561|Escherichia 1236|Gammaproteobacteria M Transfers a phosphoglycerol residue from phosphatidylglycerol to the membrane-bound nascent glucan backbones mdoB GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006490,GO:0006629,GO:0008150,GO:0008152,GO:0008960,GO:0009058,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016780,GO:0042597,GO:0044237,GO:0044238,GO:0044255,GO:0044464,GO:0071704,GO:0071944,GO:1901135,GO:1901137,GO:1901576 2.7.8.20 ko:K01002 ko01100,map01100 - - - ko00000,ko01000 - - - Sulfatase k59_1421633_1 717773.Thicy_1447 1.22e-42 147.0 COG4665@1|root,COG4665@2|Bacteria,1RHBW@1224|Proteobacteria,1S5Y0@1236|Gammaproteobacteria,4611K@72273|Thiotrichales 72273|Thiotrichales Q TRAP-type mannitol chloroaromatic compound transport system, small permease component - - - - - - - - - - - - DctQ k59_405063_1 471852.Tcur_4223 8.16e-09 58.5 COG0210@1|root,COG0210@2|Bacteria,2GISS@201174|Actinobacteria,4EFMA@85012|Streptosporangiales 201174|Actinobacteria L UvrD-like helicase C-terminal domain pcrA GO:0000018,GO:0000166,GO:0000287,GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009314,GO:0009411,GO:0009416,GO:0009628,GO:0009650,GO:0009892,GO:0009987,GO:0010605,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019219,GO:0019222,GO:0030312,GO:0030554,GO:0031323,GO:0031324,GO:0032392,GO:0032508,GO:0032552,GO:0032554,GO:0032558,GO:0032564,GO:0032991,GO:0033202,GO:0033554,GO:0034641,GO:0036094,GO:0040007,GO:0042623,GO:0043138,GO:0043140,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0045910,GO:0045934,GO:0046483,GO:0046872,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051053,GO:0051171,GO:0051172,GO:0051276,GO:0051716,GO:0060255,GO:0060542,GO:0060543,GO:0065007,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0080090,GO:0090304,GO:0097159,GO:0097367,GO:0140097,GO:1901265,GO:1901360,GO:1901363,GO:1902494 3.6.4.12 ko:K03657 ko03420,ko03430,map03420,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - UvrD-helicase,UvrD_C k59_405063_2 1158338.JNLJ01000001_gene825 1.65e-13 76.6 COG0390@1|root,COG0390@2|Bacteria,2G4AE@200783|Aquificae 200783|Aquificae S Uncharacterised protein family (UPF0014) - - - ko:K02069 - M00211 - - ko00000,ko00002,ko02000 9.B.25.1 - - UPF0014 k59_1479019_1 436308.Nmar_0677 1.44e-45 154.0 arCOG04668@1|root,arCOG04668@2157|Archaea,41SMD@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_857537_1 1123261.AXDW01000001_gene1159 5.31e-27 114.0 COG4638@1|root,COG4638@2|Bacteria,1MWXW@1224|Proteobacteria,1S9NJ@1236|Gammaproteobacteria,1X5C8@135614|Xanthomonadales 135614|Xanthomonadales P COG4638 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit - - 1.14.12.1,1.14.15.7 ko:K00499,ko:K16319 ko00260,ko00627,ko01120,map00260,map00627,map01120 M00637 R00823,R00825,R07409 RC00087,RC00192 br01602,ko00000,ko00001,ko00002,ko01000 - - - Rieske,Ring_hydroxyl_A k59_1365724_1 1123269.NX02_24630 3.52e-45 171.0 COG0243@1|root,COG0243@2|Bacteria,1NS3T@1224|Proteobacteria,2TQYD@28211|Alphaproteobacteria,2K1FR@204457|Sphingomonadales 204457|Sphingomonadales C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - - ko:K00372 ko00910,ko01120,map00910,map01120 M00531 R00798,R01106 RC02812 ko00000,ko00001,ko00002,ko01000 - - - Fer2_BFD,Molybdop_Fe4S4,Molybdopterin,Molydop_binding k59_517739_1 1122137.AQXF01000002_gene425 3.46e-132 395.0 COG1629@1|root,COG4771@2|Bacteria,1MWKN@1224|Proteobacteria,2TTFY@28211|Alphaproteobacteria 28211|Alphaproteobacteria P receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_913518_2 706587.Desti_2083 1.12e-25 104.0 COG3000@1|root,COG3000@2|Bacteria,1MW5G@1224|Proteobacteria,42NDF@68525|delta/epsilon subdivisions,2WJPS@28221|Deltaproteobacteria 28221|Deltaproteobacteria I PFAM Fatty acid hydroxylase - - - - - - - - - - - - FA_hydroxylase k59_405079_2 1229909.NSED_02340 1.74e-33 119.0 COG0454@1|root,arCOG00826@2157|Archaea 2157|Archaea K COG0454 Histone acetyltransferase HPA2 and related acetyltransferases - - - - - - - - - - - - Acetyltransf_1 k59_1591096_1 926566.Terro_0249 1.32e-23 105.0 COG1570@1|root,COG1570@2|Bacteria,3Y3DP@57723|Acidobacteria,2JIQN@204432|Acidobacteriia 204432|Acidobacteriia L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides xseA - 3.1.11.6 ko:K03601 ko03430,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - Exonuc_VII_L,tRNA_anti_2 k59_517748_1 1288494.EBAPG3_2770 1.69e-20 90.5 COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,2VH4I@28216|Betaproteobacteria,3727Q@32003|Nitrosomonadales 28216|Betaproteobacteria L UvrD REP uvrD - 3.6.4.12 ko:K03657 ko03420,ko03430,map03420,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - UvrD-helicase,UvrD_C k59_299186_2 1033810.HLPCO_000985 4.5e-159 469.0 COG0520@1|root,COG0520@2|Bacteria 2|Bacteria E Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine csdA - 2.8.1.7 ko:K04487 ko00730,ko01100,ko04122,map00730,map01100,map04122 - R07460,R11528,R11529 RC01789,RC02313 ko00000,ko00001,ko01000,ko02048,ko03016,ko03029 - - - Aminotran_5 k59_807312_1 742159.HMPREF0004_4306 6.91e-87 266.0 COG0240@1|root,COG0240@2|Bacteria,1MXI9@1224|Proteobacteria,2VW0B@28216|Betaproteobacteria,3T2P3@506|Alcaligenaceae 28216|Betaproteobacteria C Glycerol-3-phosphate dehydrogenase - - 1.5.1.28 ko:K04940 - - - - ko00000,ko01000 - - - ApbA,NAD_Gly3P_dh_N,Octopine_DH k59_467637_1 84531.JMTZ01000064_gene1863 3.19e-30 116.0 2C39A@1|root,3250C@2|Bacteria,1PX8W@1224|Proteobacteria,1T8YG@1236|Gammaproteobacteria,1XBE7@135614|Xanthomonadales 135614|Xanthomonadales - - - - - - - - - - - - - - - k59_1089298_1 1122137.AQXF01000003_gene1996 1.73e-46 159.0 COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,2TQKE@28211|Alphaproteobacteria 28211|Alphaproteobacteria I acyl-CoA dehydrogenase MA20_27425 - 1.3.8.7 ko:K00249 ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320 M00013,M00036,M00087 R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754 RC00052,RC00068,RC00076,RC00095,RC00148,RC00246 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_1089298_2 502025.Hoch_6187 1.56e-49 174.0 COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,1MUJ3@1224|Proteobacteria,42Q8W@68525|delta/epsilon subdivisions,2WJVN@28221|Deltaproteobacteria 28221|Deltaproteobacteria E PFAM peptidase S9 prolyl oligopeptidase active site domain protein - - - - - - - - - - - - PD40,Peptidase_S9 k59_919752_1 1415778.JQMM01000001_gene394 5.7e-160 467.0 COG0480@1|root,COG0480@2|Bacteria,1MUCV@1224|Proteobacteria,1RNSZ@1236|Gammaproteobacteria,1J4UF@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome fusA GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2 k59_637287_1 1128421.JAGA01000002_gene1611 1.62e-05 46.6 COG0500@1|root,COG2226@2|Bacteria,2NPGE@2323|unclassified Bacteria 2|Bacteria H Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) menG - 2.1.1.163,2.1.1.201 ko:K03183 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116,M00117 R04990,R04993,R06859,R08774,R09736 RC00003,RC01253,RC01662 ko00000,ko00001,ko00002,ko01000 - - - Ubie_methyltran k59_467641_1 984262.SGRA_1497 1.61e-29 122.0 COG0060@1|root,COG0060@2|Bacteria,4NEYT@976|Bacteroidetes,1IPPT@117747|Sphingobacteriia 976|Bacteroidetes J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) ileS - 6.1.1.5 ko:K01870 ko00970,map00970 M00359,M00360 R03656 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,tRNA-synt_1 k59_1202567_1 555793.WSK_2240 7.12e-94 284.0 COG0482@1|root,COG0482@2|Bacteria,1MUT1@1224|Proteobacteria,2TQU7@28211|Alphaproteobacteria,2K1HV@204457|Sphingomonadales 204457|Sphingomonadales J Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 mnmA - 2.8.1.13 ko:K00566 ko04122,map04122 - R08700 RC02313,RC02315 ko00000,ko00001,ko01000,ko03016 - - - tRNA_Me_trans k59_580877_1 1415779.JOMH01000001_gene2909 5.83e-58 188.0 COG1305@1|root,COG1305@2|Bacteria,1MVAG@1224|Proteobacteria,1RMXM@1236|Gammaproteobacteria,1X87H@135614|Xanthomonadales 135614|Xanthomonadales E Bacterial transglutaminase-like N-terminal region - - - - - - - - - - - - Bact_transglu_N,Transglut_core k59_580877_2 1298593.TOL_3012 6.25e-27 104.0 COG1305@1|root,COG1305@2|Bacteria,1MWAI@1224|Proteobacteria,1RRMA@1236|Gammaproteobacteria,1XJ20@135619|Oceanospirillales 135619|Oceanospirillales E Transglutaminase/protease-like homologues - - - - - - - - - - - - Transglut_core k59_750232_1 314285.KT71_11790 9.07e-68 213.0 COG0625@1|root,COG0625@2|Bacteria,1MXHH@1224|Proteobacteria,1RNWZ@1236|Gammaproteobacteria,1J7SR@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Glutathione S-transferase, C-terminal domain gstA - 2.5.1.18 ko:K00799 ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418 - R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905 RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944 ko00000,ko00001,ko01000,ko02000 1.A.12.2.2,1.A.12.3.2 - - GST_C,GST_C_3,GST_N,GST_N_3 k59_750232_2 349163.Acry_2651 1.66e-33 125.0 COG1932@1|root,COG1932@2|Bacteria,1MUB5@1224|Proteobacteria,2TSHT@28211|Alphaproteobacteria,2JPS4@204441|Rhodospirillales 204441|Rhodospirillales EH Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine serC - 2.6.1.52 ko:K00831 ko00260,ko00680,ko00750,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map00750,map01100,map01120,map01130,map01200,map01230 M00020,M00124 R04173,R05085 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_5 k59_299215_1 1089550.ATTH01000001_gene1220 1.43e-111 337.0 COG1282@1|root,COG1282@2|Bacteria,4NHGZ@976|Bacteroidetes,1FJ60@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes C The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane pntB - 1.6.1.2 ko:K00325 ko00760,ko01100,map00760,map01100 - R00112 RC00001 ko00000,ko00001,ko01000 - - - PNTB k59_750240_1 591158.SSMG_02410 7.19e-29 115.0 COG1228@1|root,COG1228@2|Bacteria,2GMUS@201174|Actinobacteria 201174|Actinobacteria Q amidohydrolase - - - - - - - - - - - - Amidohydro_1 k59_1541625_1 161528.ED21_22808 1.37e-18 85.9 COG0664@1|root,COG0664@2|Bacteria,1QU34@1224|Proteobacteria,2TVH6@28211|Alphaproteobacteria 28211|Alphaproteobacteria T COG1226 Kef-type K transport systems - - - ko:K10716 - - - - ko00000,ko02000 1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6 - - Ion_trans k59_1541625_2 1144305.PMI02_00804 1.09e-31 116.0 COG0289@1|root,COG0289@2|Bacteria,1MUCT@1224|Proteobacteria,2TSFJ@28211|Alphaproteobacteria,2K2CC@204457|Sphingomonadales 204457|Sphingomonadales E Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate dapB - 1.17.1.8 ko:K00215 ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R04198,R04199 RC00478 ko00000,ko00001,ko00002,ko01000 - - - DapB_C,DapB_N k59_1541627_2 1121374.KB891586_gene2755 1.87e-135 394.0 COG0160@1|root,COG0160@2|Bacteria,1MWY6@1224|Proteobacteria,1RQKU@1236|Gammaproteobacteria 1236|Gammaproteobacteria E Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family ectB GO:0003674,GO:0003824,GO:0006082,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0018130,GO:0019491,GO:0019752,GO:0032787,GO:0042399,GO:0043436,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.6.1.76 ko:K00836 ko00260,ko01100,ko01120,ko01210,ko01230,map00260,map01100,map01120,map01210,map01230 M00033 R06977 RC00006,RC00062 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 k59_807333_1 583345.Mmol_0423 8.17e-18 85.1 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,2KNJ1@206350|Nitrosomonadales 206350|Nitrosomonadales T PFAM EAL domain protein - - - - - - - - - - - - EAL,GGDEF,PAS_3,PAS_4 k59_807333_2 1121935.AQXX01000144_gene4408 1.75e-37 137.0 COG3146@1|root,COG3146@2|Bacteria,1MU35@1224|Proteobacteria,1RNWI@1236|Gammaproteobacteria,1XHRX@135619|Oceanospirillales 135619|Oceanospirillales S protein conserved in bacteria - - - ko:K09919 - - - - ko00000 - - - FemAB_like k59_1485593_1 1229909.NSED_02205 1.65e-25 100.0 COG1208@1|root,arCOG00663@2157|Archaea 2157|Archaea M PFAM Nucleotidyl transferase - - 2.6.1.37,2.7.7.13 ko:K00966,ko:K03430 ko00051,ko00440,ko00520,ko01100,ko01110,ko01120,map00051,map00440,map00520,map01100,map01110,map01120 M00114,M00361,M00362 R00885,R04152 RC00002,RC00008,RC00062 ko00000,ko00001,ko00002,ko01000,ko01007 - - - NTP_transferase k59_1485593_2 436308.Nmar_0423 1.57e-51 167.0 COG0066@1|root,arCOG02230@2157|Archaea,41T1U@651137|Thaumarchaeota 651137|Thaumarchaeota E 3-isopropylmalate dehydratase, small subunit - - 4.2.1.33,4.2.1.35 ko:K01704 ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230 M00432,M00535 R03896,R03898,R03968,R04001,R10170 RC00976,RC00977,RC01041,RC01046,RC03072 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase_C k59_185950_1 1244869.H261_16341 5.17e-22 100.0 COG0642@1|root,COG0784@1|root,COG2198@1|root,COG2202@1|root,COG2770@1|root,COG0784@2|Bacteria,COG2198@2|Bacteria,COG2202@2|Bacteria,COG2205@2|Bacteria,COG2770@2|Bacteria,1NRP8@1224|Proteobacteria,2TXJ2@28211|Alphaproteobacteria,2JPEA@204441|Rhodospirillales 204441|Rhodospirillales T Histidine kinase - - 2.7.13.3 ko:K11527 - - - - ko00000,ko01000,ko01001,ko02022 - - - GAF_2,HATPase_c,HisKA,Hpt,PAS_3,PAS_4,Response_reg,dCache_1 k59_185961_1 1026882.MAMP_01246 6.47e-80 246.0 COG0847@1|root,COG0847@2|Bacteria,1MV8Z@1224|Proteobacteria,1RNHQ@1236|Gammaproteobacteria,460CA@72273|Thiotrichales 72273|Thiotrichales L DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease dnaQ - 2.7.7.7 ko:K02342 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - RNase_T k59_580913_1 436308.Nmar_1569 3.29e-102 308.0 COG0516@1|root,arCOG00612@2157|Archaea,41S7R@651137|Thaumarchaeota 651137|Thaumarchaeota F Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth guaB - 1.1.1.205 ko:K00088 ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 M00050 R01130,R08240 RC00143,RC02207 ko00000,ko00001,ko00002,ko01000,ko04147 - - - CBS,IMPDH k59_1597836_1 1192034.CAP_8510 1.1e-12 63.9 COG1758@1|root,COG1758@2|Bacteria,1N6TX@1224|Proteobacteria,42V07@68525|delta/epsilon subdivisions,2WRQ6@28221|Deltaproteobacteria,2YW65@29|Myxococcales 28221|Deltaproteobacteria K Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits rpoZ - 2.7.7.6 ko:K03060 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb6 k59_1597836_2 1234364.AMSF01000079_gene1846 8.86e-23 100.0 COG0642@1|root,COG2199@1|root,COG3292@1|root,COG2205@2|Bacteria,COG3292@2|Bacteria,COG3706@2|Bacteria,1NRP8@1224|Proteobacteria,1T5SH@1236|Gammaproteobacteria,1XDEC@135614|Xanthomonadales 135614|Xanthomonadales T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA,Response_reg k59_864348_1 1042376.AFPK01000034_gene1284 3.36e-09 60.5 COG1629@1|root,COG4771@2|Bacteria,4NFAM@976|Bacteroidetes,1HWUQ@117743|Flavobacteriia 976|Bacteroidetes P TonB-dependent receptor - - - - - - - - - - - - CarbopepD_reg_2,Plug,TonB_dep_Rec k59_864348_2 1205753.A989_07308 2.54e-09 58.2 COG0659@1|root,COG0659@2|Bacteria,1MVWV@1224|Proteobacteria,1RMCN@1236|Gammaproteobacteria,1X54I@135614|Xanthomonadales 135614|Xanthomonadales P Sulfate transporter - - - ko:K03321 - - - - ko00000,ko02000 2.A.53.3 - - STAS,STAS_2,Sulfate_transp k59_637348_1 529884.Rhola_00000070 5.03e-26 107.0 COG0187@1|root,COG0187@2|Bacteria,2GKGP@201174|Actinobacteria,4FMXF@85023|Microbacteriaceae 201174|Actinobacteria L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrB GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0003916,GO:0003918,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006265,GO:0006725,GO:0006807,GO:0006996,GO:0007059,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0009295,GO:0009987,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017076,GO:0017111,GO:0030312,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034335,GO:0034641,GO:0035639,GO:0036094,GO:0040007,GO:0042623,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0046872,GO:0051276,GO:0061505,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:0097367,GO:0140097,GO:1901265,GO:1901360,GO:1901363 5.99.1.3 ko:K02470 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim k59_637348_2 1120934.KB894421_gene2511 4.7e-33 127.0 COG0188@1|root,COG0188@2|Bacteria,2GJ2Q@201174|Actinobacteria,4DYNS@85010|Pseudonocardiales 201174|Actinobacteria L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrA GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0003916,GO:0003918,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006265,GO:0006725,GO:0006807,GO:0006996,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017076,GO:0017111,GO:0030312,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034335,GO:0034641,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0046872,GO:0051276,GO:0061505,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:0097367,GO:0140097,GO:1901265,GO:1901360,GO:1901363 5.99.1.3 ko:K02469 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseA_C,DNA_topoisoIV,Intein_splicing,LAGLIDADG_3 k59_73422_1 1333856.L686_05285 1.8e-57 186.0 COG3063@1|root,COG3063@2|Bacteria,1RD9T@1224|Proteobacteria,1S3R3@1236|Gammaproteobacteria,1Z0Q2@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria NU COG0457 FOG TPR repeat - - - - - - - - - - - - TPR_19,TPR_2,TPR_8 k59_73422_2 700598.Niako_2735 3.15e-05 47.4 COG0642@1|root,COG0745@1|root,COG0784@1|root,COG3850@1|root,COG0745@2|Bacteria,COG0784@2|Bacteria,COG2205@2|Bacteria,COG3850@2|Bacteria,4NFBM@976|Bacteroidetes,1IQZ6@117747|Sphingobacteriia 976|Bacteroidetes T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - CHASE3,GAF_2,HATPase_c,HisKA,Response_reg k59_1089349_1 880071.Fleli_2470 4.49e-109 335.0 COG4772@1|root,COG4772@2|Bacteria,4NEUH@976|Bacteroidetes,47N13@768503|Cytophagia 976|Bacteroidetes P PFAM TonB-dependent Receptor Plug - - - - - - - - - - - - CarbopepD_reg_2,Plug,TonB_dep_Rec k59_1428023_1 986075.CathTA2_0646 1.53e-55 184.0 COG4608@1|root,COG4608@2|Bacteria,1V36J@1239|Firmicutes,4H9YB@91061|Bacilli 91061|Bacilli P Belongs to the ABC transporter superfamily ykfD - - ko:K02032,ko:K10823 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00239,M00439 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 - - ABC_tran,oligo_HPY k59_1428023_2 1303518.CCALI_02570 1.13e-31 119.0 COG2178@1|root,COG2178@2|Bacteria 2|Bacteria J A2A adenosine receptor binding - - - ko:K07477 - - - - ko00000 - - - - k59_580937_1 420324.KI911947_gene5554 1.36e-09 61.6 COG0363@1|root,COG0363@2|Bacteria,1R5K6@1224|Proteobacteria,2U77K@28211|Alphaproteobacteria,1JS2A@119045|Methylobacteriaceae 28211|Alphaproteobacteria G TIGRFAM 6-phosphogluconolactonase pgl - 3.1.1.31 ko:K01057 ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200 M00004,M00006,M00008 R02035 RC00537 ko00000,ko00001,ko00002,ko01000 - - - Glucosamine_iso k59_580937_2 115713.CPn_0238 1.31e-14 73.9 COG0364@1|root,COG0364@2|Bacteria,2JFEN@204428|Chlamydiae 204428|Chlamydiae G Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone zwf - 1.1.1.363,1.1.1.49 ko:K00036 ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230 M00004,M00006,M00008 R00835,R02736,R10907 RC00001,RC00066 ko00000,ko00001,ko00002,ko01000,ko04147 - - - G6PD_C,G6PD_N k59_1145589_1 1254432.SCE1572_03720 8.06e-53 188.0 COG1858@1|root,COG3391@1|root,COG1858@2|Bacteria,COG3391@2|Bacteria,1R66T@1224|Proteobacteria 1224|Proteobacteria C amine dehydrogenase activity - - - - - - - - - - - - - k59_16267_1 204669.Acid345_4600 2.98e-38 144.0 COG0624@1|root,COG0624@2|Bacteria,3Y4G2@57723|Acidobacteria,2JJG2@204432|Acidobacteriia 204432|Acidobacteriia E Peptidase dimerisation domain - - - - - - - - - - - - M20_dimer,Peptidase_M20 k59_1089365_1 1121935.AQXX01000108_gene416 1.82e-56 203.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1XH3T@135619|Oceanospirillales 135619|Oceanospirillales V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_411368_1 1088721.NSU_1708 6.16e-105 317.0 COG2133@1|root,COG2133@2|Bacteria,1MVK5@1224|Proteobacteria,2TRN9@28211|Alphaproteobacteria,2K068@204457|Sphingomonadales 204457|Sphingomonadales G sorbosone - - - - - - - - - - - - GSDH k59_1315737_1 1122137.AQXF01000005_gene1208 1.02e-72 228.0 COG0274@1|root,COG0274@2|Bacteria,1N8AG@1224|Proteobacteria,2TS26@28211|Alphaproteobacteria 28211|Alphaproteobacteria F Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate deoC - 4.1.2.4 ko:K01619 ko00030,map00030 - R01066 RC00436,RC00437 ko00000,ko00001,ko01000 - - - DeoC k59_467734_1 314287.GB2207_07537 8.39e-84 270.0 COG1884@1|root,COG1884@2|Bacteria,1MUXX@1224|Proteobacteria,1RSHX@1236|Gammaproteobacteria,1J4JG@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria I COG1884 Methylmalonyl-CoA mutase, N-terminal domain subunit scpA GO:0003674,GO:0003824,GO:0004494,GO:0005488,GO:0008144,GO:0016853,GO:0016866,GO:0019842,GO:0031419,GO:0036094,GO:0046906,GO:0048037,GO:0097159,GO:1901363 5.4.99.2 ko:K01847,ko:K01848 ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200 M00373,M00375,M00376,M00741 R00833 RC00395 ko00000,ko00001,ko00002,ko01000 - - iECO111_1330.ECO111_3653,iECO26_1355.ECO26_4004 B12-binding,MM_CoA_mutase k59_1145593_1 1415778.JQMM01000001_gene1282 3.11e-97 297.0 COG2206@1|root,COG2206@2|Bacteria,1MW7F@1224|Proteobacteria,1RPEZ@1236|Gammaproteobacteria,1J5MY@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T COG2206 HD-GYP domain - - - - - - - - - - - - DUF3391,HD,HD_5 k59_1710859_1 1458427.BAWN01000012_gene705 1.63e-93 294.0 COG1924@1|root,COG1924@2|Bacteria,1PKG6@1224|Proteobacteria,2WE9S@28216|Betaproteobacteria 28216|Betaproteobacteria I BadF/BadG/BcrA/BcrD ATPase family - - - - - - - - - - - - BcrAD_BadFG,DUF2229,HGD-D k59_1710863_1 1122137.AQXF01000002_gene40 9.22e-43 153.0 COG5002@1|root,COG5002@2|Bacteria,1MWF3@1224|Proteobacteria,2TR46@28211|Alphaproteobacteria 28211|Alphaproteobacteria T Histidine kinase phoR - 2.7.13.3 ko:K07636 ko02020,map02020 M00434 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA,PAS_4,PAS_8 k59_1428049_1 13690.CP98_01796 4.4e-64 210.0 COG1541@1|root,COG1541@2|Bacteria,1NT0G@1224|Proteobacteria,2UP2C@28211|Alphaproteobacteria,2K9AS@204457|Sphingomonadales 204457|Sphingomonadales H Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA) - - - - - - - - - - - - - k59_467747_1 1528106.JRJE01000032_gene2924 1.95e-49 169.0 COG0524@1|root,COG0524@2|Bacteria,1MUUC@1224|Proteobacteria,2TS9D@28211|Alphaproteobacteria,2JPGW@204441|Rhodospirillales 204441|Rhodospirillales G COG0524 Sugar kinases, ribokinase family pfkB - 2.7.1.4 ko:K00847 ko00051,ko00500,ko00520,ko01100,map00051,map00500,map00520,map01100 - R00760,R00867,R03920 RC00002,RC00017 ko00000,ko00001,ko01000 - - - PfkB k59_1654980_1 316407.85676291 6.19e-128 380.0 COG3158@1|root,COG3158@2|Bacteria,1MUVH@1224|Proteobacteria,1RPM6@1236|Gammaproteobacteria,3XMNU@561|Escherichia 1236|Gammaproteobacteria P Responsible for the low-affinity transport of potassium into the cell, with the kup GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015318,GO:0015672,GO:0016020,GO:0022857,GO:0022890,GO:0030001,GO:0034220,GO:0044464,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0071804,GO:0071805,GO:0071944,GO:0098655,GO:0098660,GO:0098662 - ko:K03549 - - - - ko00000,ko02000 2.A.72 - iECs_1301.ECs4689,iG2583_1286.G2583_4543,iZ_1308.Z5248 K_trans k59_1710873_1 1229909.NSED_02310 9.53e-125 368.0 COG0475@1|root,arCOG01955@2157|Archaea,41SG1@651137|Thaumarchaeota 651137|Thaumarchaeota P Sodium hydrogen exchanger - - - ko:K03455 - - - - ko00000 2.A.37 - - Na_H_Exchanger k59_1202651_1 639283.Snov_3257 2.61e-70 224.0 COG3386@1|root,COG3386@2|Bacteria,1MWTR@1224|Proteobacteria,2V93J@28211|Alphaproteobacteria,3F1WS@335928|Xanthobacteraceae 28211|Alphaproteobacteria G SMP-30/Gluconolaconase/LRE-like region - - - ko:K14274 ko00040,map00040 - R02427 RC00713 ko00000,ko00001,ko01000 - - - SGL k59_1033943_1 316407.85676645 1.47e-166 488.0 COG5009@1|root,COG5009@2|Bacteria,1MU5A@1224|Proteobacteria,1RM7J@1236|Gammaproteobacteria,3XP4D@561|Escherichia 1236|Gammaproteobacteria M penicillin-binding protein 1A mrcA GO:0000270,GO:0003674,GO:0003824,GO:0004180,GO:0004185,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006022,GO:0006023,GO:0006024,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0008238,GO:0008360,GO:0008658,GO:0008955,GO:0009002,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016021,GO:0016740,GO:0016757,GO:0016758,GO:0016787,GO:0017171,GO:0019538,GO:0022603,GO:0022604,GO:0030203,GO:0031224,GO:0031226,GO:0031406,GO:0033218,GO:0033293,GO:0034645,GO:0036094,GO:0042221,GO:0042546,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044425,GO:0044459,GO:0044464,GO:0046677,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051128,GO:0065007,GO:0065008,GO:0070008,GO:0070011,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:0097159,GO:0140096,GO:1901135,GO:1901137,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901681 2.4.1.129,3.4.16.4 ko:K05366 ko00550,ko01100,ko01501,map00550,map01100,map01501 - - - ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 - PCB_OB,Transgly,Transpeptidase k59_1089389_1 1088721.NSU_0073 5.32e-125 363.0 COG0022@1|root,COG0022@2|Bacteria,1R8KB@1224|Proteobacteria,2TRMR@28211|Alphaproteobacteria,2JZYC@204457|Sphingomonadales 28211|Alphaproteobacteria C The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) acoB - 1.2.4.1 ko:K00162,ko:K21417 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230 M00307 R00014,R00209,R01699,R03270 RC00004,RC00027,RC00627,RC02742,RC02744,RC02882 br01601,ko00000,ko00001,ko00002,ko01000 - - - Transket_pyr,Transketolase_C k59_299281_2 1030157.AFMP01000051_gene338 1.75e-37 132.0 COG0087@1|root,COG0087@2|Bacteria,1MUST@1224|Proteobacteria,2TRHB@28211|Alphaproteobacteria,2K0IE@204457|Sphingomonadales 204457|Sphingomonadales J One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit rplC - - ko:K02906 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L3 k59_1485679_1 1229781.C272_10808 6.77e-21 93.6 COG0252@1|root,COG0252@2|Bacteria,2HUB2@201174|Actinobacteria,4F91A@85019|Brevibacteriaceae 201174|Actinobacteria EJ Asparaginase - - 3.5.1.1 ko:K01424 ko00250,ko00460,ko01100,ko01110,map00250,map00460,map01100,map01110 - R00485 RC00010,RC02798 ko00000,ko00001,ko01000 - - - Asparaginase k59_1485679_2 1122137.AQXF01000002_gene454 2.32e-70 222.0 COG0686@1|root,COG0686@2|Bacteria,1QTX1@1224|Proteobacteria,2TQQC@28211|Alphaproteobacteria 28211|Alphaproteobacteria C Belongs to the AlaDH PNT family ald - 1.4.1.1 ko:K00259 ko00250,ko00430,ko01100,map00250,map00430,map01100 - R00396 RC00008 ko00000,ko00001,ko01000 - - - AlaDh_PNT_C,AlaDh_PNT_N k59_16299_1 575540.Isop_3463 5.4e-28 116.0 COG0515@1|root,COG0515@2|Bacteria,2IYTQ@203682|Planctomycetes 203682|Planctomycetes KLT PFAM Protein kinase domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase,TPR_11,TPR_16 k59_16299_2 391589.RGAI101_4157 2.6e-16 78.2 COG0631@1|root,COG0631@2|Bacteria,1MVE7@1224|Proteobacteria,2U6K4@28211|Alphaproteobacteria,2P2WV@2433|Roseobacter 28211|Alphaproteobacteria T COG0631 Serine threonine protein phosphatase - - 3.1.3.16 ko:K20074 - - - - ko00000,ko01000,ko01009 - - - PP2C_2 k59_1258783_1 1122201.AUAZ01000002_gene1082 8.4e-24 93.2 COG3209@1|root,COG3209@2|Bacteria,1N7AI@1224|Proteobacteria,1SDRH@1236|Gammaproteobacteria 1236|Gammaproteobacteria M COG3209 Rhs family protein - - - - - - - - - - - - - k59_1258783_2 870187.Thini_4018 5.31e-24 96.7 COG0716@1|root,COG0716@2|Bacteria,1MX7F@1224|Proteobacteria,1RMNT@1236|Gammaproteobacteria,4611D@72273|Thiotrichales 72273|Thiotrichales C Low-potential electron donor to a number of redox enzymes - - - ko:K03839,ko:K03840 - - - - ko00000 - - - Flavodoxin_1 k59_975626_1 1122137.AQXF01000007_gene3517 1.54e-155 444.0 COG0045@1|root,COG0045@2|Bacteria,1MVCE@1224|Proteobacteria,2TRXK@28211|Alphaproteobacteria 28211|Alphaproteobacteria C Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit sucC GO:0003674,GO:0003824,GO:0004774,GO:0004775,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016874,GO:0016877,GO:0016878,GO:0016999,GO:0017144,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0055114,GO:0071704,GO:0072350 6.2.1.5 ko:K01903 ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374,M00620 R00405,R02404 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000 - - - ATP-grasp_2,Ligase_CoA k59_1485695_1 1122137.AQXF01000001_gene2706 4.58e-71 229.0 COG4964@1|root,COG4964@2|Bacteria,1MV8G@1224|Proteobacteria,2TRNN@28211|Alphaproteobacteria 28211|Alphaproteobacteria U Belongs to the GSP D family rhcC2 - - ko:K02280 - - - - ko00000,ko02035,ko02044 - - - BON,Secretin,T2SS-T3SS_pil_N k59_1202661_1 316407.85676382 1.26e-39 132.0 2D8BC@1|root,32TQY@2|Bacteria,1N3XB@1224|Proteobacteria,1SAN1@1236|Gammaproteobacteria,3XQ5W@561|Escherichia 1236|Gammaproteobacteria - - yicS - - - - - - - - - - - - k59_1202661_2 316407.85676383 1.93e-41 142.0 COG1464@1|root,COG1464@2|Bacteria,1MUVY@1224|Proteobacteria,1RSKH@1236|Gammaproteobacteria,3XNXN@561|Escherichia 1236|Gammaproteobacteria M NLPA lipoprotein nlpA GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K02073 ko02010,map02010 M00238 - - ko00000,ko00001,ko00002,ko02000 3.A.1.24 - - Lipoprotein_9 k59_1597908_1 449447.MAE_05650 4.7e-08 61.2 COG0341@1|root,COG0341@2|Bacteria,1G075@1117|Cyanobacteria 1117|Cyanobacteria U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA secF GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944 - ko:K03074 ko03060,ko03070,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 2.A.6.4,3.A.5.2,3.A.5.7 - - SecD_SecF,Sec_GG k59_1597908_2 1121396.KB893083_gene440 2.62e-09 58.5 COG0342@1|root,COG0342@2|Bacteria,1MV5U@1224|Proteobacteria,42M6V@68525|delta/epsilon subdivisions,2WJCI@28221|Deltaproteobacteria,2MHS8@213118|Desulfobacterales 28221|Deltaproteobacteria U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA secD - - ko:K03072,ko:K12257 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 2.A.6.4,3.A.5.2,3.A.5.7 - - SecD_SecF,Sec_GG k59_1541702_1 216596.RL2231 3.81e-32 123.0 COG1043@1|root,COG1043@2|Bacteria,1MUHQ@1224|Proteobacteria,2TRK9@28211|Alphaproteobacteria,4BAB1@82115|Rhizobiaceae 28211|Alphaproteobacteria M Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell lpxA - 2.3.1.129 ko:K00677 ko00540,ko01100,ko01503,map00540,map01100,map01503 M00060 R04567 RC00039,RC00055 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Acetyltransf_11,Hexapep k59_1089416_1 1229909.NSED_09905 2.64e-113 344.0 COG1293@1|root,arCOG01695@2157|Archaea,41SB0@651137|Thaumarchaeota 651137|Thaumarchaeota K Fibronectin-binding protein A N-terminus (FbpA) - - - - - - - - - - - - DUF814,FbpA k59_975652_1 317936.Nos7107_3771 3.93e-27 103.0 COG2343@1|root,COG2343@2|Bacteria,1G50P@1117|Cyanobacteria,1HMC7@1161|Nostocales 1117|Cyanobacteria S Domain of unknown function (DUF427) - - - - - - - - - - - - NTP_transf_9 k59_975652_2 240016.ABIZ01000001_gene5304 4.14e-69 225.0 COG3046@1|root,COG3046@2|Bacteria,46U8W@74201|Verrucomicrobia,2IU7B@203494|Verrucomicrobiae 203494|Verrucomicrobiae S Deoxyribodipyrimidine photo-lyase-related protein - - - - - - - - - - - - DPRP,FAD_binding_7 k59_467784_1 555793.WSK_3012 3.03e-124 358.0 COG2022@1|root,COG2022@2|Bacteria,1N0N5@1224|Proteobacteria,2TSXS@28211|Alphaproteobacteria,2K0MM@204457|Sphingomonadales 204457|Sphingomonadales H Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S thiG - 2.8.1.10 ko:K03149 ko00730,ko01100,map00730,map01100 - R10247 RC03096,RC03097,RC03461 ko00000,ko00001,ko01000 - - - ThiG,ThiS k59_1767402_1 1218108.KB908297_gene2936 2.62e-17 80.5 COG1995@1|root,COG1995@2|Bacteria,4NEUR@976|Bacteroidetes,1HWZ8@117743|Flavobacteriia 976|Bacteroidetes H Belongs to the PdxA family pdxA - 1.1.1.262 ko:K00097 ko00750,ko01100,map00750,map01100 M00124 R05681,R05837,R07406 RC00089,RC00675,RC01475 ko00000,ko00001,ko00002,ko01000 - - - PdxA k59_1767402_2 1347342.BN863_230 1.15e-60 191.0 COG1399@1|root,COG1399@2|Bacteria,4NMQT@976|Bacteroidetes,1I17C@117743|Flavobacteriia 976|Bacteroidetes S DNA-binding protein - - - - - - - - - - - - DUF177 k59_1597924_1 1144305.PMI02_04241 7.46e-70 217.0 COG2518@1|root,COG2518@2|Bacteria,1RD6S@1224|Proteobacteria,2UAEN@28211|Alphaproteobacteria,2KD0C@204457|Sphingomonadales 204457|Sphingomonadales O Protein-L-isoaspartate O-methyltransferase - - 2.1.1.77 ko:K00573 - - - - ko00000,ko01000 - - - PCMT k59_1597924_2 1144305.PMI02_04240 1.18e-216 613.0 COG1538@1|root,COG1538@2|Bacteria,1MWCJ@1224|Proteobacteria,2TR3S@28211|Alphaproteobacteria,2JZY5@204457|Sphingomonadales 204457|Sphingomonadales MU membrane - - - ko:K12340 ko01501,ko01503,ko02020,ko03070,ko04626,ko05133,map01501,map01503,map02020,map03070,map04626,map05133 M00325,M00326,M00339,M00571,M00575,M00646,M00647,M00696,M00697,M00709,M00720,M00821 - - ko00000,ko00001,ko00002,ko01504,ko02000,ko02044 1.B.17,2.A.6.2 - - OEP k59_864432_1 1122137.AQXF01000007_gene3496 9.64e-149 420.0 COG1136@1|root,COG1136@2|Bacteria,1MU45@1224|Proteobacteria,2VEU2@28211|Alphaproteobacteria 28211|Alphaproteobacteria V ABC transporter - - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_864432_2 1122137.AQXF01000007_gene3495 1.23e-54 189.0 COG0577@1|root,COG0577@2|Bacteria,1NREW@1224|Proteobacteria,2U1KH@28211|Alphaproteobacteria 28211|Alphaproteobacteria V ABC-type antimicrobial peptide transport system, permease component - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_1710919_1 1260251.SPISAL_05925 1.73e-39 140.0 COG4544@1|root,COG4544@2|Bacteria,1MZQU@1224|Proteobacteria,1S9RP@1236|Gammaproteobacteria,1WZQP@135613|Chromatiales 135613|Chromatiales D Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division - - - ko:K14160 - - - - ko00000,ko03400 - - - SulA k59_637442_1 247490.KSU1_C0777 3.53e-55 189.0 COG3387@1|root,COG3387@2|Bacteria,2IXUW@203682|Planctomycetes 203682|Planctomycetes G Glycosyl hydrolases family 15 - - - - - - - - - - - - Glyco_hydro_15 k59_1203405_1 436308.Nmar_0872 7.01e-114 335.0 COG1759@1|root,arCOG04346@2157|Archaea,41SBR@651137|Thaumarchaeota 651137|Thaumarchaeota F Catalyzes the ATP- and formate-dependent formylation of 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'- monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1- beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates purP - 6.3.4.23 ko:K06863 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R06975 RC00263,RC00323 ko00000,ko00001,ko00002,ko01000 - - - DUF1246,DUF1297 k59_473914_1 284031.JNXD01000027_gene1421 3.33e-26 112.0 COG1020@1|root,COG1020@2|Bacteria,2GISR@201174|Actinobacteria 201174|Actinobacteria Q Non-ribosomal peptide synthetase modules and related proteins - - - - - - - - - - - - AMP-binding,AMP-binding_C,Condensation,Methyltransf_11,Methyltransf_12,Methyltransf_21,PP-binding,Thioesterase k59_1321865_1 234267.Acid_3964 2.74e-29 120.0 COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,3Y7IX@57723|Acidobacteria 57723|Acidobacteria KLT Protein tyrosine kinase - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - HAMP,Pkinase k59_1209529_1 452637.Oter_2746 1.96e-69 225.0 COG1249@1|root,COG1249@2|Bacteria,46S8I@74201|Verrucomicrobia,3K7TS@414999|Opitutae 414999|Opitutae C Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family - - - - - - - - - - - - Pyr_redox_2,Pyr_redox_dim k59_1209529_2 1115803.HMPREF1129_1252 2.74e-08 55.1 COG0693@1|root,COG0693@2|Bacteria,2HG8A@201174|Actinobacteria,4D45U@85005|Actinomycetales 201174|Actinobacteria S DJ-1 family - - - - - - - - - - - - DJ-1_PfpI k59_136333_1 1121937.AUHJ01000018_gene215 1.38e-27 108.0 COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,1RMMJ@1236|Gammaproteobacteria,46572@72275|Alteromonadaceae 1236|Gammaproteobacteria I COG1960 Acyl-CoA dehydrogenases ivd - 1.3.8.4 ko:K00253 ko00280,ko01100,map00280,map01100 M00036 R04095 RC00246 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_136333_2 1121937.AUHJ01000018_gene214 9.46e-47 153.0 COG0789@1|root,COG0789@2|Bacteria,1RITY@1224|Proteobacteria,1S61S@1236|Gammaproteobacteria,467YX@72275|Alteromonadaceae 1236|Gammaproteobacteria K helix_turn_helix, mercury resistance liuR - - - - - - - - - - - MerR,MerR-DNA-bind,MerR_1 k59_1321866_1 1485544.JQKP01000002_gene1499 3.14e-78 242.0 COG1077@1|root,COG1077@2|Bacteria,1MUMW@1224|Proteobacteria,2VIR9@28216|Betaproteobacteria,44VNI@713636|Nitrosomonadales 28216|Betaproteobacteria D TIGRFAM cell shape determining protein, MreB Mrl family mreB - - ko:K03569 - - - - ko00000,ko02048,ko03036,ko04812 1.A.33.1,9.B.157.1 - - MreB_Mbl k59_1379612_1 426114.THI_3279 2.22e-128 386.0 COG4579@1|root,COG4579@2|Bacteria,1MVRB@1224|Proteobacteria,2VJMA@28216|Betaproteobacteria,1KJHG@119065|unclassified Burkholderiales 28216|Betaproteobacteria F Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation aceK - 2.7.11.5 ko:K00906 - - - - ko00000,ko01000 - - - AceK k59_248734_2 1379270.AUXF01000001_gene2761 4.09e-19 86.7 COG2957@1|root,COG2957@2|Bacteria,1ZSZ0@142182|Gemmatimonadetes 142182|Gemmatimonadetes E Porphyromonas-type peptidyl-arginine deiminase - - 3.5.3.12 ko:K10536 ko00330,ko01100,map00330,map01100 - R01416 RC00177 ko00000,ko00001,ko01000 - - - PAD_porph k59_1605311_1 1122194.AUHU01000003_gene2357 5.94e-90 291.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,464X3@72275|Alteromonadaceae 1236|Gammaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_418482_1 1250232.JQNJ01000001_gene3865 1.78e-54 181.0 COG1082@1|root,COG1082@2|Bacteria,4NI7Y@976|Bacteroidetes,1I0CB@117743|Flavobacteriia 976|Bacteroidetes G Xylose isomerase-like TIM barrel - - 5.1.3.30,5.1.3.31 ko:K18910 - - R10817,R10818 RC03111,RC03283 ko00000,ko01000 - - - AP_endonuc_2 k59_1549107_4 1283284.AZUK01000001_gene2667 1.46e-53 193.0 28MJ5@1|root,2ZAVR@2|Bacteria,1R5CR@1224|Proteobacteria,1SCPR@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Phage stabilisation protein - - - - - - - - - - - - Phage_stabilise k59_587930_1 504487.JCM19302_2803 2.71e-49 161.0 298AX@1|root,2ZVGF@2|Bacteria,4NNYM@976|Bacteroidetes,1I1ZZ@117743|Flavobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_587930_2 391587.KAOT1_14872 1.1e-18 83.2 COG2850@1|root,COG2850@2|Bacteria,4NEJI@976|Bacteroidetes,1HWP6@117743|Flavobacteriia 976|Bacteroidetes S Cupin-like domain - - - - - - - - - - - - Cupin_8 k59_23471_1 715451.ambt_12695 2.15e-26 110.0 COG0577@1|root,COG0577@2|Bacteria,1MXFC@1224|Proteobacteria,1RQX0@1236|Gammaproteobacteria,46698@72275|Alteromonadaceae 1236|Gammaproteobacteria V FtsX-like permease family - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_1492883_1 1485545.JQLW01000005_gene1176 3.78e-15 80.1 COG2132@1|root,COG2132@2|Bacteria,1MU0J@1224|Proteobacteria 1224|Proteobacteria Q Multi-copper copA - - - - - - - - - - - CopB,Cu-oxidase,Cu-oxidase_2,Cu-oxidase_3 k59_1661337_1 87626.PTD2_14184 1.15e-13 70.9 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,2Q12B@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K03296 - - - - ko00000 2.A.6.2 - - ACR_tran k59_1661337_2 1121013.P873_03920 2.37e-09 61.2 COG0845@1|root,COG0845@2|Bacteria,1MV1T@1224|Proteobacteria,1RQTS@1236|Gammaproteobacteria,1X80N@135614|Xanthomonadales 135614|Xanthomonadales M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - - - - - - - - - - HlyD_3,HlyD_D23 k59_1773060_1 366649.XFF4834R_chr23360 2.72e-73 233.0 COG2021@1|root,COG2021@2|Bacteria,1MVJV@1224|Proteobacteria,1RQ2N@1236|Gammaproteobacteria,1X47D@135614|Xanthomonadales 135614|Xanthomonadales E Transfers a succinyl group from succinyl-CoA to L- serine, forming succinyl-L-serine metX GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004414,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008374,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009086,GO:0009092,GO:0009987,GO:0016053,GO:0016407,GO:0016413,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.3.1.31 ko:K00641 ko00270,ko01100,ko01130,map00270,map01100,map01130 - R01776 RC00004,RC00041 ko00000,ko00001,ko01000 - - - Abhydrolase_1 k59_1321903_1 1122225.AULQ01000008_gene1281 1.33e-64 223.0 COG2373@1|root,COG2373@2|Bacteria,4NED2@976|Bacteroidetes,1HWJJ@117743|Flavobacteriia 976|Bacteroidetes P Large extracellular alpha-helical protein - - - - - - - - - - - - A2M,A2M_N,A2M_N_2,CarbopepD_reg_2 k59_1264564_1 1122137.AQXF01000001_gene2726 1.18e-203 584.0 COG1506@1|root,COG1506@2|Bacteria,1MUJ3@1224|Proteobacteria,2U2CJ@28211|Alphaproteobacteria 28211|Alphaproteobacteria EU COG1506 Dipeptidyl aminopeptidases acylaminoacyl-peptidases - - - - - - - - - - - - PD40,Peptidase_S9 k59_248778_1 405948.SACE_4310 3.67e-20 95.1 COG1914@1|root,COG1914@2|Bacteria,2GMUT@201174|Actinobacteria,4E7I6@85010|Pseudonocardiales 201174|Actinobacteria P H( )-stimulated, divalent metal cation uptake system - - - - - - - - - - - - - k59_1264566_1 411467.BACCAP_00378 2.18e-20 88.2 COG1192@1|root,COG1192@2|Bacteria,1TP8S@1239|Firmicutes,2488C@186801|Clostridia,268E6@186813|unclassified Clostridiales 186801|Clostridia D Cellulose biosynthesis protein BcsQ soj - - ko:K03496 - - - - ko00000,ko03036,ko04812 - - - AAA_31 k59_1264566_2 196627.cg3426 1.83e-23 100.0 COG1475@1|root,COG1475@2|Bacteria,2GNRN@201174|Actinobacteria,22JSV@1653|Corynebacteriaceae 201174|Actinobacteria K Belongs to the ParB family parB GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005694,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044424,GO:0044464,GO:0060187,GO:0071944 - ko:K03497 - - - - ko00000,ko03000,ko03036,ko04812 - - - ParBc k59_1152748_1 546267.NEIPOLOT_00171 6.28e-23 97.8 COG0743@1|root,COG0743@2|Bacteria,1MU4G@1224|Proteobacteria,2VHJY@28216|Betaproteobacteria,2KQCN@206351|Neisseriales 206351|Neisseriales I Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) dxr - 1.1.1.267 ko:K00099 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05688 RC01452 ko00000,ko00001,ko00002,ko01000 - - - DXPR_C,DXP_redisom_C,DXP_reductoisom k59_1152748_2 1121943.KB899998_gene1560 1.27e-49 168.0 COG0575@1|root,COG0575@2|Bacteria,1MWSV@1224|Proteobacteria,1RQ6M@1236|Gammaproteobacteria,1XJNR@135619|Oceanospirillales 135619|Oceanospirillales I Belongs to the CDS family cdsA - 2.7.7.41 ko:K00981 ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070 M00093 R01799 RC00002 ko00000,ko00001,ko00002,ko01000 - - - CTP_transf_1 k59_136410_1 436308.Nmar_1686 5.48e-79 242.0 COG0540@1|root,arCOG00911@2157|Archaea,41S6H@651137|Thaumarchaeota 651137|Thaumarchaeota F aspartate carbamoyltransferase pyrB - 2.1.3.2 ko:K00609 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R01397 RC00064,RC02850 ko00000,ko00001,ko00002,ko01000 - - - OTCace,OTCace_N k59_756437_1 1280390.CBQR020000062_gene1232 1.25e-14 76.6 COG1409@1|root,COG1409@2|Bacteria,1VRZR@1239|Firmicutes,4HV90@91061|Bacilli,26S4G@186822|Paenibacillaceae 91061|Bacilli S Calcineurin-like phosphoesterase - - - - - - - - - - - - Metallophos k59_1379689_1 316407.85675600 3.48e-121 349.0 COG1694@1|root,COG3956@2|Bacteria,1MVKM@1224|Proteobacteria,1RNVU@1236|Gammaproteobacteria,3XNQT@561|Escherichia 1236|Gammaproteobacteria F mediates programmed cell death (PCD). This is achieved by lowering the cellular concentration of (p)ppGpp produced by RelA under amino acid starvation, thus protecting the cell from the toxicity of MazF. Reduction of (p)ppGpp can be achieved by direct degradation of (p)ppGpp or by degradation of NTPs, which are substrates for (p)ppGpp synthesis by RelA mazG GO:0003674,GO:0003824,GO:0006139,GO:0006163,GO:0006195,GO:0006203,GO:0006213,GO:0006220,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0007154,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009143,GO:0009144,GO:0009146,GO:0009147,GO:0009149,GO:0009151,GO:0009155,GO:0009164,GO:0009166,GO:0009199,GO:0009200,GO:0009203,GO:0009204,GO:0009208,GO:0009210,GO:0009211,GO:0009213,GO:0009215,GO:0009217,GO:0009218,GO:0009219,GO:0009222,GO:0009223,GO:0009259,GO:0009261,GO:0009262,GO:0009264,GO:0009267,GO:0009394,GO:0009605,GO:0009987,GO:0009991,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0019693,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0042454,GO:0042594,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0046046,GO:0046047,GO:0046051,GO:0046052,GO:0046060,GO:0046061,GO:0046070,GO:0046075,GO:0046076,GO:0046080,GO:0046081,GO:0046131,GO:0046133,GO:0046135,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0050896,GO:0051716,GO:0055086,GO:0071496,GO:0071704,GO:0072521,GO:0072523,GO:0072527,GO:0072529,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1901657,GO:1901658 3.6.1.9 ko:K04765 ko00230,ko00240,ko00760,ko00770,ko01100,map00230,map00240,map00760,map00770,map01100 - R00086,R00087,R00103,R00287,R00426,R00515,R00662,R00720,R03004,R03036,R11323 RC00002 ko00000,ko00001,ko01000 - - iAF1260.b2781,iBWG_1329.BWG_2516,iE2348C_1286.E2348C_3048,iEC55989_1330.EC55989_3056,iECDH10B_1368.ECDH10B_2948,iECDH1ME8569_1439.ECDH1ME8569_2691,iECH74115_1262.ECH74115_4041,iECIAI1_1343.ECIAI1_2889,iECO103_1326.ECO103_3324,iECO111_1330.ECO111_3505,iECO26_1355.ECO26_3851,iECOK1_1307.ECOK1_3155,iECP_1309.ECP_2762,iECSE_1348.ECSE_3039,iECSP_1301.ECSP_3733,iECW_1372.ECW_m2990,iECs_1301.ECs3641,iEKO11_1354.EKO11_0987,iEcDH1_1363.EcDH1_0907,iEcE24377_1341.EcE24377A_3085,iEcHS_1320.EcHS_A2925,iEcolC_1368.EcolC_0931,iG2583_1286.G2583_3433,iJO1366.b2781,iJR904.b2781,iSBO_1134.SBO_2662,iSSON_1240.SSON_2938,iSbBS512_1146.SbBS512_E3092,iUMN146_1321.UM146_02665,iUMNK88_1353.UMNK88_3464,iUTI89_1310.UTI89_C3150,iWFL_1372.ECW_m2990,iY75_1357.Y75_RS14470,iZ_1308.Z4096 MazG k59_363154_1 439235.Dalk_2496 1.1e-17 78.2 COG0454@1|root,COG0454@2|Bacteria,1RIFC@1224|Proteobacteria,42XMV@68525|delta/epsilon subdivisions,2WX09@28221|Deltaproteobacteria 28221|Deltaproteobacteria K Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_1,Acetyltransf_7 k59_363154_2 1484460.JSWG01000009_gene507 1.37e-63 199.0 28JKT@1|root,2Z9DG@2|Bacteria,4NJJK@976|Bacteroidetes,1HYPI@117743|Flavobacteriia 976|Bacteroidetes S Protein of unknown function (DUF4230) - - - - - - - - - - - - DUF4230 k59_1152760_1 1089553.Tph_c03530 1.94e-35 132.0 COG0601@1|root,COG0601@2|Bacteria,1TP1S@1239|Firmicutes,247IP@186801|Clostridia,42FXH@68295|Thermoanaerobacterales 186801|Clostridia P ABC-type dipeptide oligopeptide nickel transport systems, permease components - - - ko:K02033 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1 k59_1095682_1 1088721.NSU_0528 5.33e-109 324.0 COG2141@1|root,COG2141@2|Bacteria 2|Bacteria C COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - - - - - - - - - - Bac_luciferase k59_1152779_1 1121948.AUAC01000010_gene2988 7.95e-12 70.5 COG2909@1|root,COG2909@2|Bacteria,1MVZZ@1224|Proteobacteria,2U296@28211|Alphaproteobacteria,43XXI@69657|Hyphomonadaceae 28211|Alphaproteobacteria K helix_turn_helix, Lux Regulon - - - ko:K03556 - - - - ko00000,ko03000 - - - AAA_16,GerE k59_1492953_1 1121104.AQXH01000005_gene241 1.45e-77 250.0 COG0419@1|root,COG0419@2|Bacteria 2|Bacteria L ATPase involved in DNA repair - - - ko:K02057,ko:K03546 - M00221 - - ko00000,ko00002,ko02000,ko03400 3.A.1.2 - - AAA_23,BPD_transp_2,DUF3732 k59_1095685_2 502025.Hoch_2437 9.11e-70 226.0 COG0196@1|root,COG0196@2|Bacteria,1MV9I@1224|Proteobacteria,42MV7@68525|delta/epsilon subdivisions,2WJTU@28221|Deltaproteobacteria,2YV5E@29|Myxococcales 28221|Deltaproteobacteria H Belongs to the ribF family ribF - 2.7.1.26,2.7.7.2 ko:K11753 ko00740,ko01100,ko01110,map00740,map01100,map01110 M00125 R00161,R00549 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - FAD_syn,Flavokinase k59_981724_1 436308.Nmar_1394 1.09e-46 160.0 COG1867@1|root,arCOG01219@2157|Archaea,41SAG@651137|Thaumarchaeota 651137|Thaumarchaeota J Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family - - 2.1.1.215,2.1.1.216 ko:K00555 - - - - ko00000,ko01000,ko03016 - - - TRM k59_981724_2 436308.Nmar_1393 2.55e-57 183.0 COG0164@1|root,arCOG04121@2157|Archaea,41SK9@651137|Thaumarchaeota 651137|Thaumarchaeota L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids rnhB - 3.1.26.4 ko:K03470 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - RNase_HII k59_418574_1 1122137.AQXF01000007_gene3542 1.35e-80 257.0 COG4805@1|root,COG4805@2|Bacteria,1MUBX@1224|Proteobacteria,2TSUQ@28211|Alphaproteobacteria 1224|Proteobacteria O Protein conserved in bacteria - - - - - - - - - - - - DUF885 k59_1379721_3 1229909.NSED_09065 1.06e-47 160.0 arCOG03788@1|root,arCOG03788@2157|Archaea,41T96@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_80876_1 1124991.MU9_497 8.31e-26 106.0 COG0486@1|root,COG0486@2|Bacteria,1MUCQ@1224|Proteobacteria,1RN5S@1236|Gammaproteobacteria 1236|Gammaproteobacteria J Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 mnmE GO:0000166,GO:0001510,GO:0001882,GO:0001883,GO:0002097,GO:0002098,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005515,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006457,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009268,GO:0009451,GO:0009628,GO:0009636,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019003,GO:0030488,GO:0030955,GO:0031420,GO:0032259,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034470,GO:0034641,GO:0034660,GO:0035639,GO:0036094,GO:0042221,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0050896,GO:0061077,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901363 - ko:K03650 - - R08701 RC00053,RC00209,RC00870 ko00000,ko01000,ko03016 - - - MMR_HSR1,MnmE_helical,TrmE_N k59_80876_2 316067.Geob_1071 8.51e-18 81.3 COG0664@1|root,COG0664@2|Bacteria,1N61M@1224|Proteobacteria,42Y1U@68525|delta/epsilon subdivisions,2WNPK@28221|Deltaproteobacteria 28221|Deltaproteobacteria CT cyclic nucleotide-binding - - - - - - - - - - - - HEAT_2,TLC,cNMP_binding k59_1773099_1 436308.Nmar_0973 5.69e-74 235.0 arCOG08728@1|root,arCOG08728@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_643637_1 1121447.JONL01000010_gene2391 6.01e-09 60.8 COG1740@1|root,COG1740@2|Bacteria,1PW7V@1224|Proteobacteria,43B3H@68525|delta/epsilon subdivisions,2X6HA@28221|Deltaproteobacteria,2M9TA@213115|Desulfovibrionales 28221|Deltaproteobacteria C small subunit hysB - 1.12.99.6 ko:K06282 ko00633,ko01120,map00633,map01120 - R08034 RC00250 ko00000,ko00001,ko01000 - - - NiFe_hyd_SSU_C,Oxidored_q6 k59_1209645_1 28532.XP_010546022.1 4.68e-69 229.0 COG1012@1|root,KOG2450@2759|Eukaryota,37KEV@33090|Viridiplantae,3GBEC@35493|Streptophyta,3HQRE@3699|Brassicales 35493|Streptophyta C Aldehyde dehydrogenase family - GO:0000166,GO:0003674,GO:0003824,GO:0004029,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0008144,GO:0008150,GO:0008152,GO:0009507,GO:0009536,GO:0010035,GO:0010038,GO:0016491,GO:0016620,GO:0016903,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042221,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464,GO:0046686,GO:0050896,GO:0055114,GO:0097159,GO:0097367,GO:1901265,GO:1901363 1.2.1.3 ko:K00128 ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130 M00135 R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146 RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_756470_1 1122137.AQXF01000001_gene2696 8.49e-27 100.0 COG2261@1|root,COG2261@2|Bacteria 2|Bacteria S Transglycosylase associated protein ydaS - - - - - - - - - - - Transgly_assoc k59_756470_2 1122137.AQXF01000001_gene2697 2.09e-23 98.2 COG0665@1|root,COG0665@2|Bacteria,1MY0G@1224|Proteobacteria,2TRM2@28211|Alphaproteobacteria 28211|Alphaproteobacteria E COG0665 Glycine D-amino acid oxidases (deaminating) - - 1.4.99.6 ko:K19746 ko00472,ko01100,map00472,map01100 - R11018 RC00006 ko00000,ko00001,ko01000 - - - DAO k59_1379744_1 107636.JQNK01000009_gene1811 1.62e-06 50.1 COG2370@1|root,COG2370@2|Bacteria,1N08F@1224|Proteobacteria,2UA0Y@28211|Alphaproteobacteria,36YJD@31993|Methylocystaceae 28211|Alphaproteobacteria O HupE / UreJ protein hupE GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K03192 - - - - ko00000 - - - HupE_UreJ k59_1379744_2 1123393.KB891326_gene136 2.07e-46 163.0 COG0374@1|root,COG0374@2|Bacteria,1MWFJ@1224|Proteobacteria,2VJ52@28216|Betaproteobacteria,1KSIG@119069|Hydrogenophilales 119069|Hydrogenophilales C Nickel-dependent hydrogenase - - - - - - - - - - - - NiFeSe_Hases k59_80898_1 1034943.BN1094_02769 8.23e-19 88.6 COG2819@1|root,COG2819@2|Bacteria,1RB1X@1224|Proteobacteria,1S6C2@1236|Gammaproteobacteria,1JDRS@118969|Legionellales 118969|Legionellales S Putative esterase besA - - ko:K07017 - - - - ko00000 - - - Esterase k59_1321966_1 1147128.BAST_0401 5.01e-25 107.0 COG0153@1|root,COG0153@2|Bacteria,2GJXI@201174|Actinobacteria,4CZNV@85004|Bifidobacteriales 201174|Actinobacteria G Belongs to the GHMP kinase family. GalK subfamily galK - 2.7.1.6,2.7.7.12 ko:K00849,ko:K00965 ko00052,ko00520,ko01100,ko04917,map00052,map00520,map01100,map04917 M00362,M00554,M00632 R00955,R01092 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000,ko04147 - - - GHMP_kinases_C,GHMP_kinases_N,GalKase_gal_bdg k59_1152822_1 1392490.JHZX01000001_gene3045 4.64e-46 158.0 COG3264@1|root,COG3264@2|Bacteria,4NEAM@976|Bacteroidetes,1HYUA@117743|Flavobacteriia 976|Bacteroidetes M mechanosensitive ion channel - - - - - - - - - - - - MS_channel k59_1152822_2 983544.Lacal_0253 8.92e-24 98.6 COG1668@1|root,COG1668@2|Bacteria,4NFSZ@976|Bacteroidetes,1HXQA@117743|Flavobacteriia 976|Bacteroidetes CP ABC transporter (Permease) natB - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_3 k59_474031_1 1278078.G419_19229 3.54e-86 268.0 COG1960@1|root,COG1960@2|Bacteria,2GKQI@201174|Actinobacteria,4FZ3X@85025|Nocardiaceae 201174|Actinobacteria I acyl-CoA dehydrogenase - - 1.3.8.7 ko:K00249 ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320 M00013,M00036,M00087 R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754 RC00052,RC00068,RC00076,RC00095,RC00148,RC00246 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_418618_1 257313.BP0798 8.54e-60 197.0 COG1171@1|root,COG1171@2|Bacteria,1MVWJ@1224|Proteobacteria,2VKC7@28216|Betaproteobacteria,3T757@506|Alcaligenaceae 28216|Betaproteobacteria E Threonine dehydratase tdcB - 4.3.1.19 ko:K01754 ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230 M00570 R00220,R00996 RC00418,RC02600 ko00000,ko00001,ko00002,ko01000 - - - ACT,ACT_4,PALP k59_1718226_1 1121935.AQXX01000105_gene322 1.06e-44 159.0 COG1752@1|root,COG1752@2|Bacteria,1PDQ2@1224|Proteobacteria,1RMWI@1236|Gammaproteobacteria,1XIQ4@135619|Oceanospirillales 135619|Oceanospirillales S esterase of the alpha-beta hydrolase superfamily - - - ko:K07001 - - - - ko00000 - - - Patatin k59_306556_1 1122137.AQXF01000003_gene1980 1.8e-120 357.0 COG1609@1|root,COG1609@2|Bacteria,1MW7E@1224|Proteobacteria,2TV4Q@28211|Alphaproteobacteria 28211|Alphaproteobacteria K Transcriptional - - - - - - - - - - - - LacI,Peripla_BP_3 k59_872909_1 861299.J421_1699 2.48e-18 89.4 COG2866@1|root,COG2866@2|Bacteria,1ZSQ1@142182|Gemmatimonadetes 142182|Gemmatimonadetes E Zinc carboxypeptidase - - - - - - - - - - - - Peptidase_M14 k59_757309_1 1125863.JAFN01000001_gene2524 1.23e-26 111.0 COG0682@1|root,COG0682@2|Bacteria,1MVE3@1224|Proteobacteria,42M2I@68525|delta/epsilon subdivisions,2WNPT@28221|Deltaproteobacteria 28221|Deltaproteobacteria M Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins lgt - - ko:K13292 - - - - ko00000,ko01000 - - - LGT k59_1380977_1 1229909.NSED_04290 3.49e-85 253.0 COG0163@1|root,arCOG01703@2157|Archaea,41SHU@651137|Thaumarchaeota 651137|Thaumarchaeota H Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN ubiX - 2.5.1.129 ko:K03186 ko00130,ko00627,ko00940,ko01100,ko01110,ko01120,ko01220,map00130,map00627,map00940,map01100,map01110,map01120,map01220 M00117 R01238,R02952,R03367,R04985,R04986,R11225 RC00391,RC00814,RC03392 ko00000,ko00001,ko00002,ko01000 - - - Flavoprotein k59_1435223_1 365528.KB891103_gene4037 4.77e-46 155.0 COG0353@1|root,COG0353@2|Bacteria,2GJY0@201174|Actinobacteria,4ES6F@85013|Frankiales 201174|Actinobacteria L May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO recR - - ko:K06187 ko03440,map03440 - - - ko00000,ko00001,ko03400 - - - HHH,RecR,Toprim_4 k59_1435223_2 326427.Cagg_1696 1.08e-33 127.0 COG0438@1|root,COG0438@2|Bacteria,2G8BD@200795|Chloroflexi,376YK@32061|Chloroflexia 32061|Chloroflexia M PFAM glycosyl transferase group 1 - - - - - - - - - - - - DUF3524,Glycos_transf_1 k59_1042663_1 1235794.C811_01207 1.85e-35 137.0 COG5265@1|root,COG5265@2|Bacteria,2I6AF@201174|Actinobacteria,4CUQX@84998|Coriobacteriia 84998|Coriobacteriia O ABC transporter - - - ko:K06147 - - - - ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran k59_757312_1 880073.Calab_2887 2.33e-56 190.0 COG2204@1|root,COG2204@2|Bacteria,2NQHI@2323|unclassified Bacteria 2|Bacteria T Sigma-54 interaction domain - - - ko:K02481,ko:K07714 ko02020,map02020 M00500 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_474868_1 744979.R2A130_2050 1.91e-29 121.0 COG0187@1|root,COG0187@2|Bacteria,1MVKT@1224|Proteobacteria,2TRBK@28211|Alphaproteobacteria 28211|Alphaproteobacteria L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrB - 5.99.1.3 ko:K02470 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim k59_1773849_1 1347342.BN863_19560 2.71e-84 273.0 COG0308@1|root,COG0308@2|Bacteria,4NEJR@976|Bacteroidetes,1HYMW@117743|Flavobacteriia 976|Bacteroidetes E aminopeptidase N - - - - - - - - - - - - Peptidase_M1 k59_982668_1 1033734.CAET01000043_gene544 5.55e-13 70.1 COG5001@1|root,COG5001@2|Bacteria,1TP8V@1239|Firmicutes,4HA3G@91061|Bacilli,1ZAVY@1386|Bacillus 91061|Bacilli T Diguanylate cyclase - - - - - - - - - - - - EAL,GAF_2,GGDEF,PAS,PAS_4,PAS_9 k59_982668_2 247639.MGP2080_14289 3.11e-78 234.0 COG0105@1|root,COG0105@2|Bacteria,1R9ZA@1224|Proteobacteria,1S1Z3@1236|Gammaproteobacteria,1J617@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria F Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate ndk GO:0003674,GO:0003824,GO:0004550,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006165,GO:0006220,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009132,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0019205,GO:0019637,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046939,GO:0055086,GO:0071704,GO:0072521,GO:0072527,GO:1901360,GO:1901564 2.7.4.6 ko:K00940 ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016 M00049,M00050,M00052,M00053 R00124,R00139,R00156,R00330,R00570,R00722,R01137,R01857,R02093,R02326,R02331,R03530,R11894,R11895 RC00002 ko00000,ko00001,ko00002,ko01000,ko04131 - - - NDK k59_1042676_2 887898.HMPREF0551_1129 5.2e-27 110.0 COG0500@1|root,COG2226@2|Bacteria,1QTWC@1224|Proteobacteria,2VQ89@28216|Betaproteobacteria,1K213@119060|Burkholderiaceae 28216|Betaproteobacteria Q PFAM Methyltransferase type 11 - - - - - - - - - - - - Methyltransf_11 k59_982669_2 1229909.NSED_02200 4.25e-69 212.0 COG0066@1|root,arCOG02230@2157|Archaea,41T1U@651137|Thaumarchaeota 651137|Thaumarchaeota E 3-isopropylmalate dehydratase, small subunit - - 4.2.1.33,4.2.1.35 ko:K01704 ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230 M00432,M00535 R03896,R03898,R03968,R04001,R10170 RC00976,RC00977,RC01041,RC01046,RC03072 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase_C k59_1380991_1 266117.Rxyl_2832 1.03e-39 150.0 COG0277@1|root,COG0277@2|Bacteria,2GJ2T@201174|Actinobacteria,4CRXQ@84995|Rubrobacteria 84995|Rubrobacteria C FAD linked oxidases, C-terminal domain - - - ko:K11472 ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130 - R00475 RC00042 ko00000,ko00001 - - - FAD-oxidase_C,FAD_binding_4 k59_1389153_1 1122137.AQXF01000001_gene3248 3.57e-101 303.0 COG1806@1|root,COG1806@2|Bacteria,1MUHU@1224|Proteobacteria,2TT66@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation MA20_24795 - 2.7.11.33,2.7.4.28 ko:K09773 - - - - ko00000,ko01000 - - - Kinase-PPPase k59_1559295_1 1484460.JSWG01000011_gene1698 7.82e-99 289.0 28H8R@1|root,2Z7KJ@2|Bacteria,4NGZN@976|Bacteroidetes,1I08A@117743|Flavobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_1328380_1 1144305.PMI02_01702 1.04e-96 286.0 COG1028@1|root,COG1028@2|Bacteria,1MWSK@1224|Proteobacteria,2U7J0@28211|Alphaproteobacteria,2K4Z5@204457|Sphingomonadales 204457|Sphingomonadales IQ overlaps another CDS with the same product name - - - - - - - - - - - - adh_short_C2 k59_650454_1 1229909.NSED_04245 1e-21 91.3 arCOG08714@1|root,arCOG08714@2157|Archaea,41SPW@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_650454_2 1229909.NSED_04240 5.07e-41 136.0 arCOG10546@1|root,arCOG10546@2157|Archaea,41SRD@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_650454_3 1229909.NSED_04235 1.57e-19 81.6 arCOG10545@1|root,arCOG10545@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_650454_4 1131266.ARWQ01000002_gene601 1.65e-34 120.0 COG1656@1|root,arCOG04290@2157|Archaea,41T6F@651137|Thaumarchaeota 651137|Thaumarchaeota S Mut7-C RNAse domain - - - - - - - - - - - - - k59_650454_5 1229909.NSED_04200 1.63e-29 109.0 arCOG11446@1|root,arCOG11446@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_650454_6 1229909.NSED_04195 1.23e-38 131.0 arCOG05565@1|root,arCOG05565@2157|Archaea,41T3I@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_200209_1 95619.PM1_0218625 4.14e-14 72.0 COG1741@1|root,COG1741@2|Bacteria,1MWIP@1224|Proteobacteria,1RNVM@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Belongs to the pirin family XCC2717 - - ko:K06911 - - - - ko00000 - - - Pirin,Pirin_C k59_144065_1 1123035.ARLA01000022_gene680 1.19e-52 181.0 COG0367@1|root,COG0367@2|Bacteria,4NKKP@976|Bacteroidetes,1IA9Q@117743|Flavobacteriia,4C48I@83612|Psychroflexus 976|Bacteroidetes E Asparagine synthase - - - - - - - - - - - - Asn_synthase k59_144065_2 1484460.JSWG01000001_gene2351 4.76e-10 59.7 COG0438@1|root,COG0438@2|Bacteria,4NKJN@976|Bacteroidetes,1HXIZ@117743|Flavobacteriia 976|Bacteroidetes M Glycosyltransferase Family 4 - - - - - - - - - - - - Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1 k59_1389164_1 1229909.NSED_09205 5.46e-81 249.0 COG0371@1|root,arCOG00982@2157|Archaea,41T0B@651137|Thaumarchaeota 651137|Thaumarchaeota C Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea egsA - 1.1.1.261 ko:K00096 ko00564,map00564 - R05679,R05680 RC00029 ko00000,ko00001,ko01000 - - - Fe-ADH_2 k59_1389164_2 1229909.NSED_09210 7.4e-78 238.0 COG1047@1|root,arCOG00980@2157|Archaea,41T0T@651137|Thaumarchaeota 651137|Thaumarchaeota O Peptidyl-prolyl cis-trans - - 5.2.1.8 ko:K01802 - - - - ko00000,ko01000 - - - FKBP_C k59_597307_1 511.JT27_12230 5.22e-79 249.0 COG0541@1|root,COG0541@2|Bacteria,1MVIA@1224|Proteobacteria,2VJ3W@28216|Betaproteobacteria,3T1HR@506|Alcaligenaceae 28216|Betaproteobacteria U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components ffh - 3.6.5.4 ko:K03106 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko01000,ko02044 3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9 - - SRP54,SRP54_N,SRP_SPB k59_315917_1 633131.TR2A62_0347 7.67e-05 45.1 2EZN5@1|root,32SD4@2|Bacteria,1MZYB@1224|Proteobacteria,2UEUG@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - Sulfotransfer_1 k59_315917_2 1041147.AUFB01000005_gene2573 5.7e-19 84.3 COG3474@1|root,COG3474@2|Bacteria,1MZGS@1224|Proteobacteria,2UCUT@28211|Alphaproteobacteria,4BF2Q@82115|Rhizobiaceae 28211|Alphaproteobacteria C Cytochrome c - - - ko:K08738 ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416 M00595 R10151 RC03151,RC03152 ko00000,ko00001,ko00002 3.D.4.6 - - Cytochrom_C k59_535860_1 1288494.EBAPG3_25320 1.2e-88 286.0 COG1450@1|root,COG1450@2|Bacteria,1MUUA@1224|Proteobacteria,2VI7X@28216|Betaproteobacteria,373F0@32003|Nitrosomonadales 28216|Betaproteobacteria NU Bacterial type II/III secretion system short domain gspD - - ko:K02453 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - Secretin,Secretin_N k59_32977_1 1322246.BN4_11242 8.83e-14 78.6 COG1629@1|root,COG4771@2|Bacteria,1MWKN@1224|Proteobacteria,42MNM@68525|delta/epsilon subdivisions,2WMEW@28221|Deltaproteobacteria,2M8IE@213115|Desulfovibrionales 28221|Deltaproteobacteria P TonB dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_932851_2 1463853.JOHW01000035_gene6579 4.5e-31 114.0 COG0500@1|root,COG2226@2|Bacteria,2I3BB@201174|Actinobacteria 201174|Actinobacteria Q Methyltransferase domain - - - - - - - - - - - - Methyltransf_11 k59_480612_1 583355.Caka_2459 8.38e-116 350.0 COG0449@1|root,COG0449@2|Bacteria,46S94@74201|Verrucomicrobia,3K75B@414999|Opitutae 414999|Opitutae M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source glmS - 2.6.1.16 ko:K00820 ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931 - R00768 RC00010,RC00163,RC02752 ko00000,ko00001,ko01000,ko01002 - - - GATase_6,SIS k59_710498_1 247639.MGP2080_04975 7.77e-22 97.1 COG1680@1|root,COG1680@2|Bacteria,1MVPR@1224|Proteobacteria,1RQGQ@1236|Gammaproteobacteria 1236|Gammaproteobacteria V COG1680 Beta-lactamase class C and other penicillin binding proteins - - - - - - - - - - - - Beta-lactamase k59_710498_2 314256.OG2516_17735 0.000111 43.9 COG3653@1|root,COG3653@2|Bacteria,1MWWY@1224|Proteobacteria,2TT5E@28211|Alphaproteobacteria,2PEPM@252301|Oceanicola 28211|Alphaproteobacteria Q Amidohydrolase family MA20_04810 - 3.5.1.82 ko:K01461 - - - - ko00000,ko01000 - - - Amidohydro_3 k59_820593_1 1122603.ATVI01000005_gene3638 2.5e-16 82.0 COG0642@1|root,COG2205@2|Bacteria,1MUZQ@1224|Proteobacteria,1RMZT@1236|Gammaproteobacteria,1X3FI@135614|Xanthomonadales 135614|Xanthomonadales T Histidine kinase kdpD - 2.7.13.3 ko:K07646 ko02020,map02020 M00454 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - DUF4118,GAF_3,HATPase_c,HisKA,KdpD,Usp k59_820593_2 1408311.JNJM01000035_gene178 9.03e-12 66.2 COG0745@1|root,COG0745@2|Bacteria,1V042@1239|Firmicutes,24IM1@186801|Clostridia,2PRP7@265975|Oribacterium 186801|Clostridia KT cheY-homologous receiver domain - - - - - - - - - - - - Hemerythrin,Response_reg k59_1726332_1 391603.FBALC1_01112 9.89e-07 55.8 2FDRJ@1|root,345SI@2|Bacteria,4P5E6@976|Bacteroidetes,1IAH2@117743|Flavobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - Polysacc_synt_C k59_372608_1 1408418.JNJH01000002_gene2776 2.83e-56 193.0 COG0642@1|root,COG2205@2|Bacteria,1MW8M@1224|Proteobacteria,2TUSJ@28211|Alphaproteobacteria,2JQSP@204441|Rhodospirillales 204441|Rhodospirillales T Histidine kinase - - - - - - - - - - - - HATPase_c,HisKA k59_597335_1 395494.Galf_0211 6.11e-28 114.0 COG4942@1|root,COG4942@2|Bacteria,1MY3E@1224|Proteobacteria,2VIV9@28216|Betaproteobacteria,44VHE@713636|Nitrosomonadales 28216|Betaproteobacteria D Peptidase family M23 envC - - - - - - - - - - - Peptidase_M23 k59_1502327_1 316407.1736879 4.86e-114 336.0 COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,1RM93@1236|Gammaproteobacteria,3XMFA@561|Escherichia 1236|Gammaproteobacteria I acetoacetic acid catabolic process atoB GO:0003674,GO:0003824,GO:0003985,GO:0003988,GO:0005488,GO:0005515,GO:0006082,GO:0006091,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016043,GO:0016054,GO:0016407,GO:0016408,GO:0016453,GO:0016740,GO:0016746,GO:0016747,GO:0017144,GO:0019395,GO:0019626,GO:0019752,GO:0022607,GO:0030258,GO:0032787,GO:0034440,GO:0042737,GO:0042802,GO:0043436,GO:0043438,GO:0043442,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0046395,GO:0046459,GO:0046950,GO:0046952,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:0072329,GO:1901568,GO:1901569,GO:1901575,GO:1902224 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - iAF1260.b2224,iB21_1397.B21_02110,iBWG_1329.BWG_1998,iEC042_1314.EC042_2465,iECBD_1354.ECBD_1435,iECB_1328.ECB_02151,iECDH10B_1368.ECDH10B_2382,iECDH1ME8569_1439.ECDH1ME8569_2159,iECD_1391.ECD_02151,iETEC_1333.ETEC_2358,iEcDH1_1363.EcDH1_1434,iEcolC_1368.EcolC_1426,iJO1366.b2224,iJR904.b2224,iY75_1357.Y75_RS11660 Thiolase_C,Thiolase_N k59_372618_1 1088721.NSU_0928 4.19e-69 211.0 COG0203@1|root,COG0203@2|Bacteria,1RCWN@1224|Proteobacteria,2U749@28211|Alphaproteobacteria,2K4J0@204457|Sphingomonadales 204457|Sphingomonadales J Ribosomal protein L17 rplQ - - ko:K02879 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L17 k59_820607_1 1121013.P873_12090 3.09e-75 242.0 COG0612@1|root,COG0612@2|Bacteria,1MU6R@1224|Proteobacteria,1RN3E@1236|Gammaproteobacteria,1X8AF@135614|Xanthomonadales 135614|Xanthomonadales S Insulinase (Peptidase family M16) - - - - - - - - - - - - Peptidase_M16,Peptidase_M16_C k59_1271649_1 203122.Sde_0374 9.12e-76 245.0 COG0187@1|root,COG0187@2|Bacteria,1MVH1@1224|Proteobacteria,1RMCI@1236|Gammaproteobacteria,464P4@72275|Alteromonadaceae 1236|Gammaproteobacteria L Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule parE - - ko:K02622 - - - - ko00000,ko01000,ko02048,ko03032,ko03036 - - - DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim k59_425112_1 1415778.JQMM01000001_gene1892 2.28e-95 310.0 COG1074@1|root,COG1074@2|Bacteria,1MUTF@1224|Proteobacteria,1RPC6@1236|Gammaproteobacteria,1J4ZX@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L Belongs to the helicase family. UvrD subfamily addA - - - - - - - - - - - PDDEXK_1,UvrD-helicase,UvrD_C k59_480640_1 926569.ANT_04140 1.89e-100 314.0 COG0542@1|root,COG0542@2|Bacteria,2G62D@200795|Chloroflexi 200795|Chloroflexi O ATPase associated with various cellular activities, AAA_5 - - - ko:K03696 ko01100,map01100 - - - ko00000,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N k59_988619_1 1540221.JQNI01000002_gene2723 5e-24 100.0 COG3485@1|root,COG3485@2|Bacteria,1WJMF@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus Q Dioxygenase - - - - - - - - - - - - Dioxygenase_C k59_710553_1 1247649.D560_3430 1.06e-29 112.0 COG0589@1|root,COG0589@2|Bacteria,1N8EJ@1224|Proteobacteria,2VUAF@28216|Betaproteobacteria,3T4MW@506|Alcaligenaceae 28216|Betaproteobacteria T Universal stress protein - - - - - - - - - - - - Usp k59_1559389_1 1265503.KB905163_gene2318 2.22e-57 192.0 COG0628@1|root,COG0628@2|Bacteria,1MVX7@1224|Proteobacteria,1RNN1@1236|Gammaproteobacteria,2Q5V7@267889|Colwelliaceae 1236|Gammaproteobacteria S AI-2E family transporter - - - - - - - - - - - - AI-2E_transport k59_372658_1 859657.RPSI07_0648 1.08e-44 159.0 COG4324@1|root,COG4324@2|Bacteria,1N0FE@1224|Proteobacteria,2VH73@28216|Betaproteobacteria,1K6J1@119060|Burkholderiaceae 28216|Betaproteobacteria S zinc protease protein - - - - - - - - - - - - Aminopep k59_1328434_1 1229909.NSED_05840 8.73e-167 486.0 COG0145@1|root,arCOG01511@2157|Archaea,41SZ7@651137|Thaumarchaeota 651137|Thaumarchaeota E N-methylhydantoinase A acetone carboxylase, beta subunit - - - - - - - - - - - - Hydant_A_N,Hydantoinase_A k59_1218384_1 1185766.DL1_03675 1.33e-17 79.7 COG1309@1|root,COG1309@2|Bacteria,1RA4T@1224|Proteobacteria,2U0G2@28211|Alphaproteobacteria,2XMZY@285107|Thioclava 28211|Alphaproteobacteria K Bacterial transcriptional repressor C-terminal - - - ko:K16137 - - - - ko00000,ko03000 - - - TetR_C_13,TetR_N k59_1218384_2 1353528.DT23_08090 1.02e-81 251.0 COG0604@1|root,COG0604@2|Bacteria,1MV3W@1224|Proteobacteria,2TRW7@28211|Alphaproteobacteria,2XMBE@285107|Thioclava 28211|Alphaproteobacteria C Zinc-binding dehydrogenase - - - ko:K19745 ko00640,ko01100,map00640,map01100 - R00919 RC00095 ko00000,ko00001,ko01000 - - - ADH_N,ADH_zinc_N k59_480652_2 626887.J057_03895 1.29e-83 258.0 COG0772@1|root,COG0772@2|Bacteria,1MUK3@1224|Proteobacteria,1RMEJ@1236|Gammaproteobacteria,464B2@72275|Alteromonadaceae 1236|Gammaproteobacteria M Peptidoglycan polymerase that is essential for cell wall elongation mrdB GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008360,GO:0016020,GO:0022603,GO:0022604,GO:0044464,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0065007,GO:0065008,GO:0071944 - ko:K05837 - - - - ko00000,ko03036 - - - FTSW_RODA_SPOVE k59_1389258_1 479435.Kfla_5344 5.22e-40 140.0 COG1670@1|root,COG1670@2|Bacteria,2HF41@201174|Actinobacteria,4DUZ7@85009|Propionibacteriales 201174|Actinobacteria J Siderophore biosynthesis protein domain - - - - - - - - - - - - Acetyltransf_8 k59_1389258_2 1318628.MARLIPOL_10421 1.76e-36 140.0 COG0477@1|root,COG2814@2|Bacteria,1R43U@1224|Proteobacteria,1RMY8@1236|Gammaproteobacteria 1236|Gammaproteobacteria EGP COG0477 Permeases of the major facilitator superfamily - - - - - - - - - - - - MFS_1 k59_598759_2 983920.Y88_2176 1.34e-18 76.6 COG0257@1|root,COG0257@2|Bacteria,1NGBJ@1224|Proteobacteria,2UJAG@28211|Alphaproteobacteria,2K7QY@204457|Sphingomonadales 204457|Sphingomonadales J Belongs to the bacterial ribosomal protein bL36 family rpmJ - - ko:K02919 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L36 k59_34359_1 283699.D172_4095 7.44e-47 162.0 COG3279@1|root,COG3279@2|Bacteria,1R90R@1224|Proteobacteria,1S3H3@1236|Gammaproteobacteria,2Q1PP@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria KT LytTr DNA-binding domain rpfD - - - - - - - - - - - LytTR k59_201593_1 63737.Npun_F6342 3.52e-28 111.0 COG0500@1|root,COG2226@2|Bacteria,1G0WT@1117|Cyanobacteria,1HMI2@1161|Nostocales 1117|Cyanobacteria Q Dimerisation domain - - - - - - - - - - - - Dimerisation2,Methyltransf_2 k59_201593_2 472759.Nhal_1403 4.73e-48 161.0 COG0372@1|root,COG0372@2|Bacteria,1RCFK@1224|Proteobacteria,1S2C0@1236|Gammaproteobacteria,1X11A@135613|Chromatiales 135613|Chromatiales C Belongs to the citrate synthase family - - - - - - - - - - - - Citrate_synt k59_933897_1 110662.Syncc9605_1527 7.14e-20 87.8 2DMF8@1|root,32R47@2|Bacteria,1GQ1H@1117|Cyanobacteria,1H0BU@1129|Synechococcus 1117|Cyanobacteria S Lipocalin-like domain - - - - - - - - - - - - Lipocalin_5 k59_989535_1 504472.Slin_4616 1.14e-17 89.7 COG0577@1|root,COG0577@2|Bacteria,4NDUK@976|Bacteroidetes,47JYF@768503|Cytophagia 976|Bacteroidetes V MacB-like periplasmic core domain - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_201598_1 34506.g2227 9.39e-62 214.0 COG0524@1|root,COG0642@1|root,KOG0519@2759|Eukaryota,KOG2855@2759|Eukaryota 2759|Eukaryota G carbohydrate kinase activity - - - - - - - - - - - - HATPase_c,HisKA,PAS,PfkB,Response_reg k59_1329402_2 1321773.HMPREF9069_01169 2.22e-63 196.0 COG0197@1|root,COG0197@2|Bacteria,2IFEI@201174|Actinobacteria,4CVN3@84998|Coriobacteriia 84998|Coriobacteriia J Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs rplP - - ko:K02878 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L16 k59_373987_1 1056816.JAFQ01000004_gene2204 3.34e-41 149.0 COG2124@1|root,COG2124@2|Bacteria,2GNZS@201174|Actinobacteria,4G8MD@85025|Nocardiaceae 201174|Actinobacteria Q Cytochrome P450 - - - - - - - - - - - - p450 k59_598778_1 526225.Gobs_0167 3.15e-58 191.0 COG1028@1|root,COG1028@2|Bacteria,2GIYQ@201174|Actinobacteria,4EUSJ@85013|Frankiales 201174|Actinobacteria IQ Short-chain dehydrogenase reductase SDR - - - - - - - - - - - - adh_short k59_989544_1 314345.SPV1_06254 7.46e-48 172.0 COG0398@1|root,COG1249@1|root,COG0398@2|Bacteria,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria 1224|Proteobacteria C COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes merA - - - - - - - - - - - Pyr_redox_2,Pyr_redox_dim,SNARE_assoc k59_1560846_1 382464.ABSI01000010_gene3668 3.89e-212 602.0 COG0843@1|root,COG0843@2|Bacteria,46S4Q@74201|Verrucomicrobia,2ITKY@203494|Verrucomicrobiae 203494|Verrucomicrobiae C Cytochrome C and Quinol oxidase polypeptide I - - - - - - - - - - - - COX1 k59_1103806_1 396588.Tgr7_2960 2.31e-70 218.0 COG0689@1|root,COG0689@2|Bacteria,1MVFZ@1224|Proteobacteria,1RNTB@1236|Gammaproteobacteria,1WW0F@135613|Chromatiales 135613|Chromatiales J Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates rph - 2.7.7.56 ko:K00989 - - - - ko00000,ko01000,ko03016 - - - RNase_PH,RNase_PH_C k59_1727308_1 658172.CKC_03935 5.85e-17 88.2 COG3064@1|root,COG3064@2|Bacteria,1R6JV@1224|Proteobacteria,2U5NE@28211|Alphaproteobacteria,4BCUU@82115|Rhizobiaceae 28211|Alphaproteobacteria M Membrane - - - - - - - - - - - - - k59_598783_1 876044.IMCC3088_2132 1.47e-99 307.0 COG1228@1|root,COG1228@2|Bacteria,1MXXR@1224|Proteobacteria,1RRK7@1236|Gammaproteobacteria,1J7PK@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria Q COG1228 Imidazolonepropionase and related amidohydrolases - - - - - - - - - - - - Amidohydro_1,Amidohydro_3 k59_821972_1 316407.85675719 7.41e-34 125.0 COG0654@1|root,COG0654@2|Bacteria,1MU6I@1224|Proteobacteria,1RMS3@1236|Gammaproteobacteria,3XNK9@561|Escherichia 1236|Gammaproteobacteria CH 2-octaprenyl-6-methoxyphenol hydroxylase ubiH GO:0003674,GO:0003824,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008681,GO:0009058,GO:0009108,GO:0009314,GO:0009416,GO:0009628,GO:0009987,GO:0016491,GO:0016705,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0050896,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:1901576,GO:1901661,GO:1901663 - ko:K03185,ko:K18800 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00117 R04987,R04989,R08768,R08773 RC00046,RC02670 ko00000,ko00001,ko00002,ko01000 - - iB21_1397.B21_02702,iECBD_1354.ECBD_0830,iECB_1328.ECB_02739,iECD_1391.ECD_02739,iEcHS_1320.EcHS_A3066 FAD_binding_3 k59_821972_2 316407.85675718 1.17e-82 254.0 COG0654@1|root,COG0654@2|Bacteria,1MU6I@1224|Proteobacteria,1RND5@1236|Gammaproteobacteria,3XMGD@561|Escherichia 1236|Gammaproteobacteria CH FAD-dependent monooxygenase required for the aerobic hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy- phenol, the first hydroxylation step in coenzyme Q (ubiquinone) biosynthesis visC GO:0003674,GO:0003824,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016491,GO:0019168,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:1901576,GO:1901661,GO:1901663 - ko:K18800 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00117 R04987,R08768 RC00046 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_3 k59_259296_2 1131266.ARWQ01000010_gene31 2.96e-08 54.3 arCOG11448@1|root,arCOG11448@2157|Archaea,41T9T@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_989546_1 1268240.ATFI01000003_gene5203 3.54e-12 65.5 2DSMC@1|root,33GP4@2|Bacteria,4P61U@976|Bacteroidetes,2FUPT@200643|Bacteroidia,4ATQW@815|Bacteroidaceae 976|Bacteroidetes S Domain of unknown function (DUF4326) - - - - - - - - - - - - DUF4326 k59_426108_1 1380394.JADL01000011_gene3850 4.38e-24 106.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,2TQR7@28211|Alphaproteobacteria,2JQ44@204441|Rhodospirillales 204441|Rhodospirillales T methyl-accepting chemotaxis protein - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - HAMP,MCPsignal,sCache_2 k59_821984_1 653733.Selin_2431 4.44e-65 213.0 COG0016@1|root,COG0016@2|Bacteria 2|Bacteria J phenylalanine-tRNA ligase activity pheS GO:0003674,GO:0003824,GO:0004812,GO:0004826,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.20 ko:K01889 ko00970,map00970 M00359,M00360 R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iAF987.Gmet_1415 Phe_tRNA-synt_N,tRNA-synt_2d k59_536786_1 375286.mma_2206 7.68e-60 200.0 COG5323@1|root,COG5323@2|Bacteria 2|Bacteria M Terminase RNaseH-like domain - - - - - - - - - - - - Terminase_6 k59_1614738_1 1089552.KI911559_gene2918 5.07e-100 317.0 COG0845@1|root,COG1994@1|root,COG0845@2|Bacteria,COG1994@2|Bacteria,1MW9I@1224|Proteobacteria,2U0H8@28211|Alphaproteobacteria,2JR3V@204441|Rhodospirillales 204441|Rhodospirillales M Product type - - - ko:K16922 - - - - ko00000,ko01002 - - - Biotin_lipoyl_2,HlyD_3 k59_201624_1 292459.STH3277 8.63e-79 256.0 COG1132@1|root,COG1132@2|Bacteria,1TP0B@1239|Firmicutes,247Q0@186801|Clostridia 186801|Clostridia V ABC transporter - - - ko:K18889 ko02010,map02010 M00707 - - ko00000,ko00001,ko00002,ko02000 3.A.1.106.13,3.A.1.106.5 - - ABC_membrane,ABC_tran k59_201624_2 1356854.N007_09835 6.34e-10 67.0 COG1132@1|root,COG1132@2|Bacteria,1TP0B@1239|Firmicutes,4HESN@91061|Bacilli,279AB@186823|Alicyclobacillaceae 91061|Bacilli V ABC transporter transmembrane region - - - ko:K18890 ko02010,map02010 M00707 - - ko00000,ko00001,ko00002,ko02000 3.A.1.106.13,3.A.1.106.5 - - ABC_membrane,ABC_tran k59_651560_1 272560.BPSS1971 1.13e-24 107.0 COG2199@1|root,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria,2VV1V@28216|Betaproteobacteria,1KFBZ@119060|Burkholderiaceae 28216|Betaproteobacteria T PFAM GGDEF domain containing protein - - - - - - - - - - - - GGDEF,dCache_1 k59_1390629_1 1536774.H70357_23090 4.28e-41 149.0 COG3386@1|root,COG3386@2|Bacteria,1V1TK@1239|Firmicutes,4HG0A@91061|Bacilli,26S9U@186822|Paenibacillaceae 91061|Bacilli G SMP-30 Gluconolaconase LRE domain protein yvrE GO:0003674,GO:0003824,GO:0004341,GO:0005488,GO:0005509,GO:0005575,GO:0005576,GO:0005975,GO:0005996,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0016051,GO:0016053,GO:0016787,GO:0016788,GO:0019752,GO:0019852,GO:0019853,GO:0042364,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046364,GO:0046394,GO:0046872,GO:0051186,GO:0051188,GO:0052689,GO:0071704,GO:1901576 - ko:K14274 ko00040,map00040 - R02427 RC00713 ko00000,ko00001,ko01000 - - - SGL k59_989560_2 1266925.JHVX01000003_gene558 2.24e-38 138.0 COG2334@1|root,COG2334@2|Bacteria,1MUKJ@1224|Proteobacteria,2VH2I@28216|Betaproteobacteria,37292@32003|Nitrosomonadales 28216|Betaproteobacteria F Belongs to the pseudomonas-type ThrB family thrB - 2.7.1.39 ko:K02204 ko00260,ko01100,ko01110,ko01120,ko01230,map00260,map01100,map01110,map01120,map01230 M00018 R01771 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - APH k59_933931_1 1211115.ALIQ01000095_gene271 9.51e-117 349.0 COG0438@1|root,COG0438@2|Bacteria,1NJ19@1224|Proteobacteria,2TRT4@28211|Alphaproteobacteria 28211|Alphaproteobacteria M glycosyl transferase - - - - - - - - - - - - Glyco_trans_1_4,Glyco_trans_4_3,Glycos_transf_1 k59_1442287_1 1382306.JNIM01000001_gene281 2.46e-66 219.0 COG0438@1|root,COG0438@2|Bacteria 2|Bacteria M transferase activity, transferring glycosyl groups rfaG GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008194,GO:0008610,GO:0008653,GO:0008919,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033692,GO:0034637,GO:0034645,GO:0035251,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0046401,GO:0046527,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 - ko:K02844 ko00540,ko01100,map00540,map01100 M00080 - - ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT4 iSDY_1059.SDY_4061 Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1 k59_1560891_1 701176.VIBRN418_07716 1.26e-05 44.7 2CJWQ@1|root,32YI2@2|Bacteria,1N769@1224|Proteobacteria,1SCNV@1236|Gammaproteobacteria,1XYAE@135623|Vibrionales 135623|Vibrionales S Phage shock protein B pspB - - ko:K03970 - - - - ko00000,ko02048 - - - PspB k59_1110511_1 1415779.JOMH01000001_gene125 9.43e-34 133.0 COG1331@1|root,COG1331@2|Bacteria,1MUUT@1224|Proteobacteria,1SYRW@1236|Gammaproteobacteria,1XCQ8@135614|Xanthomonadales 135614|Xanthomonadales O Protein of unknown function, DUF255 - - - - - - - - - - - - Thioredox_DsbH k59_1279109_1 441620.Mpop_0588 7.09e-15 78.2 COG3386@1|root,COG3386@2|Bacteria,1MU0C@1224|Proteobacteria,2TSXG@28211|Alphaproteobacteria,1JU78@119045|Methylobacteriaceae 28211|Alphaproteobacteria G PFAM SMP-30 Gluconolaconase LRE domain protein - - 3.1.1.17 ko:K01053,ko:K14274 ko00030,ko00040,ko00053,ko00930,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,map00030,map00040,map00053,map00930,map01100,map01110,map01120,map01130,map01200,map01220 M00129 R01519,R02427,R02933,R03751 RC00537,RC00713,RC00983 ko00000,ko00001,ko00002,ko01000,ko04147 - - - SGL k59_324636_1 857087.Metme_1262 1.35e-23 105.0 COG1475@1|root,COG3209@1|root,COG1475@2|Bacteria,COG3209@2|Bacteria,1MVV1@1224|Proteobacteria,1RP75@1236|Gammaproteobacteria,1XE8X@135618|Methylococcales 135618|Methylococcales M TIGRFAM RHS repeat-associated core domain - - - - - - - - - - - - RHS_repeat k59_1675694_2 1356852.N008_18180 4.07e-25 107.0 COG0285@1|root,COG0285@2|Bacteria,4NES8@976|Bacteroidetes,47K0F@768503|Cytophagia 976|Bacteroidetes H Belongs to the folylpolyglutamate synthase family folC - 6.3.2.12,6.3.2.17 ko:K11754 ko00790,ko01100,map00790,map01100 M00126,M00841 R00942,R02237,R04241 RC00064,RC00090,RC00162 ko00000,ko00001,ko00002,ko01000 - - - Mur_ligase_M k59_1510723_1 1089552.KI911559_gene1839 9e-47 166.0 COG0380@1|root,COG0380@2|Bacteria,1MUIY@1224|Proteobacteria,2TQMP@28211|Alphaproteobacteria,2JPVA@204441|Rhodospirillales 204441|Rhodospirillales G Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor otsA - 2.4.1.15,2.4.1.347 ko:K00697 ko00500,ko01100,map00500,map01100 - R02737 RC00005,RC00049,RC02748 ko00000,ko00001,ko01000,ko01003 - GT20 - Glyco_transf_20 k59_889615_1 1122194.AUHU01000005_gene808 3.81e-57 199.0 COG0525@1|root,COG0525@2|Bacteria,1MV7B@1224|Proteobacteria,1RNEB@1236|Gammaproteobacteria,465F9@72275|Alteromonadaceae 1236|Gammaproteobacteria J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner valS GO:0000287,GO:0002161,GO:0003674,GO:0003824,GO:0004812,GO:0004832,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006417,GO:0006418,GO:0006438,GO:0006450,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0016070,GO:0016787,GO:0016788,GO:0016874,GO:0016875,GO:0019222,GO:0019538,GO:0019752,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0034248,GO:0034250,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045727,GO:0045903,GO:0046483,GO:0046872,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0052689,GO:0060255,GO:0061475,GO:0065007,GO:0065008,GO:0071704,GO:0080090,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:2000112 6.1.1.9 ko:K01873 ko00970,map00970 M00359,M00360 R03665 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iECH74115_1262.ECH74115_5779,iECNA114_1301.ECNA114_4481,iECO26_1355.ECO26_5428,iECSP_1301.ECSP_5359,iECs_1301.ECs5235,iG2583_1286.G2583_5088,iJN746.PP_0977,iSBO_1134.SBO_4182,iSSON_1240.SSON_4443,iYL1228.KPN_04663,iZ_1308.Z5870 Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1 k59_1785664_1 944480.ATUV01000002_gene27 3.76e-61 204.0 COG0493@1|root,COG0493@2|Bacteria,1MU2H@1224|Proteobacteria,42MGY@68525|delta/epsilon subdivisions,2WJHC@28221|Deltaproteobacteria,2M6BV@213113|Desulfurellales 28221|Deltaproteobacteria E Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster nfnA - 1.4.1.13,1.4.1.14 ko:K00266 ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 - R00093,R00114,R00248 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - DHODB_Fe-S_bind,Fer4_20,Pyr_redox_2 k59_829187_1 1229909.NSED_08325 5.53e-65 211.0 COG0644@1|root,arCOG00570@2157|Archaea,41SBB@651137|Thaumarchaeota 651137|Thaumarchaeota C Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains - - - - - - - - - - - - - k59_1568298_1 1415778.JQMM01000001_gene1832 2.37e-113 361.0 COG1643@1|root,COG1643@2|Bacteria,1MUEQ@1224|Proteobacteria,1RMU1@1236|Gammaproteobacteria,1J5AR@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L COG1643 HrpA-like helicases hrpA GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0006139,GO:0006396,GO:0006397,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0034641,GO:0042623,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0070035,GO:0071704,GO:0090304,GO:0140098,GO:1901360 3.6.4.13 ko:K03578 - - - - ko00000,ko01000 - - - DEAD,DUF3418,HA2,Helicase_C,OB_NTP_bind k59_1675703_1 1232410.KI421417_gene2746 4.34e-44 163.0 COG0439@1|root,COG0511@1|root,COG0439@2|Bacteria,COG0511@2|Bacteria,1N71M@1224|Proteobacteria,42YTA@68525|delta/epsilon subdivisions,2WU1N@28221|Deltaproteobacteria,43TAW@69541|Desulfuromonadales 28221|Deltaproteobacteria I Biotin carboxylase C-terminal domain - - - - - - - - - - - - Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2 k59_1675703_2 637389.Acaty_c0985 3.43e-109 323.0 COG2326@1|root,COG2326@2|Bacteria,1MVE2@1224|Proteobacteria,1RM9U@1236|Gammaproteobacteria,2NCPD@225057|Acidithiobacillales 225057|Acidithiobacillales S Polyphosphate kinase 2 (PPK2) - - - - - - - - - - - - PPK2 k59_1110547_1 155864.EDL933_5182 4.31e-112 324.0 COG0218@1|root,COG0218@2|Bacteria,1MY3Z@1224|Proteobacteria,1RNJP@1236|Gammaproteobacteria,3XN28@561|Escherichia 1236|Gammaproteobacteria D Necessary for normal cell division and for the maintenance of normal septation engB GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0017076,GO:0019001,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - ko:K03978 - - - - ko00000,ko03036 - - - MMR_HSR1 k59_1568311_1 1122137.AQXF01000006_gene739 3.07e-61 199.0 COG1171@1|root,COG1171@2|Bacteria,1MVWJ@1224|Proteobacteria,2TQN9@28211|Alphaproteobacteria 28211|Alphaproteobacteria E threonine dehydratase - - 4.3.1.19 ko:K01754 ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230 M00570 R00220,R00996 RC00418,RC02600 ko00000,ko00001,ko00002,ko01000 - - - PALP k59_1568311_2 13690.CP98_05040 8.7e-38 129.0 COG3785@1|root,COG3785@2|Bacteria,1RHM7@1224|Proteobacteria,2U9MS@28211|Alphaproteobacteria,2K54K@204457|Sphingomonadales 204457|Sphingomonadales S DNA-binding protein - - - ko:K11940 - - - - ko00000,ko03036 - - - YccV-like k59_996112_1 1485545.JQLW01000012_gene1762 9.18e-30 118.0 COG0633@1|root,COG1018@1|root,COG0633@2|Bacteria,COG1018@2|Bacteria,1REP4@1224|Proteobacteria 1224|Proteobacteria C Oxidoreductase FAD-binding domain - - 1.17.1.1,1.18.1.7 ko:K00523,ko:K14581 ko00520,ko00624,ko00626,ko00627,ko00633,ko00642,ko01100,ko01120,ko01220,map00520,map00624,map00626,map00627,map00633,map00642,map01100,map01120,map01220 M00534,M00638 R02968,R03391,R03392,R05422,R05423,R05424,R05425,R05426,R05427,R06909,R06930,R06937,R07704,R07706,R07709,R07710,R09159,R09233 RC00091,RC00098,RC00157,RC00230,RC00274,RC00275,RC00490,RC01376,RC01377,RC01801 br01602,ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_6,Fer2,NAD_binding_1 k59_1785682_1 748247.AZKH_2300 7.06e-08 58.2 COG2128@1|root,COG2128@2|Bacteria,1RI8R@1224|Proteobacteria,2W5ZT@28216|Betaproteobacteria 28216|Betaproteobacteria S Carboxymuconolactone decarboxylase family - - - - - - - - - - - - CMD k59_1169690_1 1121918.ARWE01000001_gene3366 4.64e-119 373.0 COG5013@1|root,COG5013@2|Bacteria,1MW9S@1224|Proteobacteria,42P6X@68525|delta/epsilon subdivisions,2WK8U@28221|Deltaproteobacteria,43U3A@69541|Desulfuromonadales 28221|Deltaproteobacteria C Molybdopterin oxidoreductase Fe4S4 domain - - 1.7.5.1 ko:K00370 ko00910,ko01120,ko02020,map00910,map01120,map02020 M00529,M00530,M00804 R00798,R01106,R09497 RC02812 ko00000,ko00001,ko00002,ko01000 5.A.3.1 - - Molybdopterin,Molydop_binding k59_1621163_1 94624.Bpet4513 1.38e-92 283.0 COG4091@1|root,COG4091@2|Bacteria,1MUZX@1224|Proteobacteria,2VI2Z@28216|Betaproteobacteria,3T3EX@506|Alcaligenaceae 28216|Betaproteobacteria E Homoserine dehydrogenase, NAD binding domain-containing protein - - - - - - - - - - - - GFO_IDH_MocA,NAD_binding_3,SAF k59_42407_2 1382358.JHVN01000002_gene2205 9.69e-40 139.0 COG2065@1|root,COG2065@2|Bacteria,1V3GV@1239|Firmicutes,4HGYE@91061|Bacilli,21WAW@150247|Anoxybacillus 91061|Bacilli F Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant pyrR GO:0003674,GO:0003700,GO:0006139,GO:0006220,GO:0006221,GO:0006355,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0019637,GO:0019693,GO:0031323,GO:0031326,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0055086,GO:0060255,GO:0065007,GO:0071704,GO:0072527,GO:0072528,GO:0080090,GO:0090407,GO:0140110,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1903506,GO:2000112,GO:2001141 2.4.2.9 ko:K02825 ko00240,ko01100,map00240,map01100 - R00966 RC00063 ko00000,ko00001,ko01000,ko03000 - - - Pribosyltran k59_830224_2 316274.Haur_0876 2.91e-11 61.6 COG3832@1|root,COG3832@2|Bacteria 2|Bacteria J glyoxalase III activity - - - - - - - - - - - - AHSA1,Polyketide_cyc2 k59_382117_1 999550.KI421507_gene2650 1.4e-59 203.0 COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TR1S@28211|Alphaproteobacteria 28211|Alphaproteobacteria T signal transduction histidine kinase - - 2.7.13.3 ko:K02482 - - - - ko00000,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,HisKA,sCache_3_3 k59_607288_1 598467.BrE312_0727 2.69e-08 60.5 COG2079@1|root,COG2079@2|Bacteria,1R5UM@1224|Proteobacteria,1RS1P@1236|Gammaproteobacteria 1236|Gammaproteobacteria S protein involved in propionate catabolism - - 4.2.1.79 ko:K01720 ko00640,map00640 - R04424 RC01152 ko00000,ko00001,ko01000 - - - MmgE_PrpD k59_1226579_1 1229909.NSED_03095 5.39e-123 361.0 COG1060@1|root,arCOG00656@2157|Archaea,41SDT@651137|Thaumarchaeota 651137|Thaumarchaeota H Radical SAM - - 2.5.1.77 ko:K11781 ko00680,ko01120,map00680,map01120 M00378 R09396 RC01381,RC03002,RC03007 ko00000,ko00001,ko00002,ko01000 - - - Radical_SAM k59_1170550_1 330214.NIDE3251 2.71e-94 304.0 COG3696@1|root,COG3696@2|Bacteria 2|Bacteria P silver ion transport - - - ko:K15726 - - - - ko00000,ko02000 2.A.6.1.2 - - ACR_tran k59_152374_1 713587.THITH_06140 1.47e-75 248.0 COG2225@1|root,COG2225@2|Bacteria,1MVEV@1224|Proteobacteria,1RPVI@1236|Gammaproteobacteria,1WXV7@135613|Chromatiales 135613|Chromatiales C Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA glcB - 2.3.3.9 ko:K01638 ko00620,ko00630,ko01100,ko01110,ko01120,ko01200,map00620,map00630,map01100,map01110,map01120,map01200 M00012 R00472 RC00004,RC00308,RC02747 ko00000,ko00001,ko00002,ko01000 - - - Malate_synthase k59_771375_1 1122137.AQXF01000001_gene2718 5.24e-90 278.0 COG1228@1|root,COG1228@2|Bacteria,1MXQX@1224|Proteobacteria,2U1V8@28211|Alphaproteobacteria 28211|Alphaproteobacteria Q overlaps another CDS with the same product name - - - - - - - - - - - - - k59_1336632_1 402881.Plav_2180 1.76e-84 262.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2TQPG@28211|Alphaproteobacteria,1JPMA@119043|Rhodobiaceae 28211|Alphaproteobacteria K Sigma-54 interaction domain flbD - - ko:K10943 ko02020,ko05111,map02020,map05111 M00515 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_1676621_1 1415778.JQMM01000001_gene917 9.44e-100 293.0 COG3748@1|root,COG3748@2|Bacteria,1RFIZ@1224|Proteobacteria,1S219@1236|Gammaproteobacteria,1J8ZE@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Urate oxidase N-terminal - - - - - - - - - - - - Urate_ox_N k59_42436_1 555793.WSK_3878 1.25e-120 350.0 COG0752@1|root,COG0752@2|Bacteria,1MVCJ@1224|Proteobacteria,2TS2N@28211|Alphaproteobacteria,2K1RK@204457|Sphingomonadales 204457|Sphingomonadales J glycyl-tRNA synthetase alpha subunit glyQ - 6.1.1.14 ko:K01878 ko00970,map00970 M00360 R03654 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_2e k59_489098_1 309807.SRU_0387 6.44e-74 241.0 COG3387@1|root,COG3387@2|Bacteria,4NEE6@976|Bacteroidetes,1FIRQ@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes G Glycosyl hydrolases family 15 - - - - - - - - - - - - Glyco_hydro_15 k59_941597_1 1323663.AROI01000016_gene419 7.34e-18 81.6 COG4795@1|root,COG4795@2|Bacteria 2|Bacteria U General secretion pathway protein gspJ - - ko:K02459 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - N_methyl,T2SSJ k59_1450199_1 436308.Nmar_0864 3.77e-41 144.0 arCOG06534@1|root,arCOG06534@2157|Archaea 2157|Archaea S acid phosphatase activity - - - - - - - - - - - - He_PIG k59_1734668_1 1122137.AQXF01000001_gene2869 5.79e-39 137.0 COG1028@1|root,COG1028@2|Bacteria,1MUSQ@1224|Proteobacteria,2TTJC@28211|Alphaproteobacteria 28211|Alphaproteobacteria IQ Short-chain dehydrogenase reductase sdr - - - ko:K13775 ko00281,map00281 - R08087,R08096,R10125,R10126 RC00080,RC00087 ko00000,ko00001 - - - adh_short,adh_short_C2 k59_1734668_2 1122137.AQXF01000001_gene2870 3.22e-116 339.0 COG0287@1|root,COG0287@2|Bacteria,1QTZA@1224|Proteobacteria,2TS12@28211|Alphaproteobacteria 28211|Alphaproteobacteria E prephenate dehydrogenase tyrC GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006082,GO:0006520,GO:0006570,GO:0006571,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008977,GO:0009058,GO:0009072,GO:0009073,GO:0009095,GO:0009987,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0019438,GO:0019752,GO:0036094,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046983,GO:0047794,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0070403,GO:0071704,GO:0097159,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.3.1.12,1.3.1.43 ko:K00210,ko:K00220,ko:K04517 ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230 M00025,M00040 R00732,R01728 RC00125 ko00000,ko00001,ko00002,ko01000 - - - PDH k59_1511637_1 768066.HELO_3053 2.68e-60 201.0 COG2256@1|root,COG2256@2|Bacteria,1MUVS@1224|Proteobacteria,1RPBY@1236|Gammaproteobacteria,1XHFX@135619|Oceanospirillales 135619|Oceanospirillales L ATPase related to the helicase subunit of the Holliday junction resolvase ycaJ - - ko:K07478 - - - - ko00000 - - - AAA,AAA_assoc_2,MgsA_C,RuvB_N k59_1734669_1 1123279.ATUS01000001_gene1224 3.44e-112 340.0 COG0129@1|root,COG0129@2|Bacteria,1MU3T@1224|Proteobacteria,1RMNA@1236|Gammaproteobacteria,1J4FW@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria EG Belongs to the IlvD Edd family edd GO:0003674,GO:0003824,GO:0004456,GO:0005975,GO:0006082,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016052,GO:0016054,GO:0016829,GO:0016835,GO:0016836,GO:0019520,GO:0019521,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044262,GO:0044275,GO:0044281,GO:0044282,GO:0046176,GO:0046177,GO:0046395,GO:0071704,GO:0072329,GO:1901575 4.2.1.12 ko:K01690 ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200 M00008 R02036 RC00543 ko00000,ko00001,ko00002,ko01000 - - iEcolC_1368.EcolC_1781,iJN746.PP_1010,iPC815.YPO2533,iYL1228.KPN_02366 ILVD_EDD k59_1676644_1 391589.RGAI101_3229 3.1e-49 178.0 COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TQQ9@28211|Alphaproteobacteria,2P2PM@2433|Roseobacter 28211|Alphaproteobacteria T Histidine kinase - - - - - - - - - - - - CHASE3,HATPase_c,HisKA,PAS_3,PAS_4,PAS_7,PAS_9,Response_reg k59_1280021_1 316407.85676298 5.68e-133 377.0 COG0357@1|root,COG0357@2|Bacteria,1MY0K@1224|Proteobacteria,1RMRZ@1236|Gammaproteobacteria,3XMZH@561|Escherichia 1236|Gammaproteobacteria J Specifically methylates the N7 position of guanine in position 527 of 16S rRNA rsmG GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036265,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070043,GO:0070475,GO:0070476,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.170 ko:K03501 - - - - ko00000,ko01000,ko03009,ko03036 - - - GidB k59_1734673_1 452637.Oter_1817 7.59e-111 333.0 COG3534@1|root,COG3534@2|Bacteria,46TJZ@74201|Verrucomicrobia,3K9HJ@414999|Opitutae 414999|Opitutae G alpha-L-arabinofuranosidase domain protein - - 3.2.1.55 ko:K01209 ko00520,map00520 - R01762 - ko00000,ko00001,ko01000 - GH51 - Alpha-L-AF_C k59_1058790_1 517722.AEUE01000002_gene2400 1.37e-30 120.0 COG0606@1|root,COG0606@2|Bacteria,1MU4R@1224|Proteobacteria,2TQU6@28211|Alphaproteobacteria,2K1A3@204457|Sphingomonadales 204457|Sphingomonadales O ATPase with chaperone activity - - - ko:K07391 - - - - ko00000 - - - ChlI,Mg_chelatase,Mg_chelatase_C k59_544232_2 395492.Rleg2_2465 1.51e-44 157.0 29X6Q@1|root,30IVV@2|Bacteria,1QZEA@1224|Proteobacteria,2TY78@28211|Alphaproteobacteria,4B9JD@82115|Rhizobiaceae 28211|Alphaproteobacteria S RecT family - - - - - - - - - - - - RecT k59_607329_2 1122947.FR7_1597 3.75e-15 81.3 COG0438@1|root,COG0438@2|Bacteria,1TPS8@1239|Firmicutes 1239|Firmicutes M glycosyl transferase group 1 - - - ko:K00754 - - - - ko00000,ko01000 - GT4 - Glyco_transf_4,Glycos_transf_1 k59_98204_1 702113.PP1Y_Mpl6750 1.34e-98 308.0 COG0045@1|root,COG1042@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,1MW98@1224|Proteobacteria,2TR24@28211|Alphaproteobacteria,2K9SN@204457|Sphingomonadales 204457|Sphingomonadales C CoA binding domain - - - - - - - - - - - - ATP-grasp_5,CoA_binding_2,Succ_CoA_lig k59_1511647_1 349521.HCH_01121 1.48e-114 332.0 COG0124@1|root,COG0124@2|Bacteria,1MYIG@1224|Proteobacteria,1SQAY@1236|Gammaproteobacteria 1236|Gammaproteobacteria J tRNA synthetase class II - - - - - - - - - - - - tRNA-synt_His k59_267494_1 1232429.CBLL010000087_gene874 7.22e-26 107.0 COG0508@1|root,COG0508@2|Bacteria,2GMUV@201174|Actinobacteria,1W856@1268|Micrococcaceae 201174|Actinobacteria C Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex sucB GO:0003674,GO:0003824,GO:0004148,GO:0005488,GO:0005504,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0008152,GO:0008289,GO:0009405,GO:0009987,GO:0015036,GO:0016020,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0019725,GO:0030312,GO:0031405,GO:0031406,GO:0032991,GO:0033293,GO:0036094,GO:0040007,GO:0042592,GO:0043167,GO:0043168,GO:0043177,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0045254,GO:0045454,GO:0048037,GO:0050662,GO:0050789,GO:0050794,GO:0051704,GO:0055114,GO:0065007,GO:0065008,GO:0071944,GO:0097159,GO:1901363,GO:1901681,GO:1902494,GO:1990204 2.3.1.61 ko:K00658 ko00020,ko00310,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00032 R02570,R02571,R08549 RC00004,RC02727,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - 2-oxoacid_dh,Biotin_lipoyl,E3_binding k59_1398933_1 1121923.GPUN_0080 3.32e-84 276.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria 1236|Gammaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family mtrD_1 - - ko:K18138 ko01501,ko01503,map01501,map01503 M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000 2.A.6.2 - - ACR_tran k59_325501_1 1089552.KI911559_gene1838 3.1e-145 429.0 COG3387@1|root,COG3387@2|Bacteria,1MV08@1224|Proteobacteria,2TRMQ@28211|Alphaproteobacteria,2JQKZ@204441|Rhodospirillales 204441|Rhodospirillales G Glycosyl hydrolases family 15 - - - - - - - - - - - - Glyco_hydro_15 k59_1569372_1 498211.CJA_1513 1.31e-91 280.0 COG0019@1|root,COG0019@2|Bacteria,1MW3T@1224|Proteobacteria,1RP8C@1236|Gammaproteobacteria,1FGJ0@10|Cellvibrio 1236|Gammaproteobacteria E Belongs to the Orn Lys Arg decarboxylase class-II family. NspC subfamily nspC GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006576,GO:0006595,GO:0006596,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008216,GO:0008295,GO:0009058,GO:0009308,GO:0009309,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0019842,GO:0030170,GO:0034641,GO:0036094,GO:0042401,GO:0042710,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0044010,GO:0044106,GO:0044237,GO:0044249,GO:0044271,GO:0044764,GO:0045312,GO:0046204,GO:0046983,GO:0048037,GO:0050662,GO:0051704,GO:0070279,GO:0071704,GO:0097159,GO:0097164,GO:1901363,GO:1901564,GO:1901566,GO:1901576 4.1.1.96 ko:K13747 ko00330,ko01100,map00330,map01100 - R09081,R09082 RC00299 ko00000,ko00001,ko01000 - - - Orn_DAP_Arg_deC k59_1569372_2 754477.Q7C_156 5.48e-07 50.8 COG0010@1|root,COG0010@2|Bacteria,1MVFH@1224|Proteobacteria,1RMH5@1236|Gammaproteobacteria,4617A@72273|Thiotrichales 72273|Thiotrichales E Belongs to the arginase family - - 3.5.3.11 ko:K01480 ko00330,ko01100,map00330,map01100 M00133 R01157 RC00024,RC00329 ko00000,ko00001,ko00002,ko01000 - - - Arginase k59_42477_1 1254432.SCE1572_36420 1.11e-35 127.0 COG3436@1|root,COG3436@2|Bacteria,1RHDW@1224|Proteobacteria,43BFC@68525|delta/epsilon subdivisions,2X6TQ@28221|Deltaproteobacteria,2Z3CQ@29|Myxococcales 28221|Deltaproteobacteria L IS66 Orf2 like protein - - - ko:K07484 - - - - ko00000 - - - TnpB_IS66 k59_771421_1 481448.Minf_0020 8.77e-95 300.0 COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,46SVA@74201|Verrucomicrobia,37FY0@326457|unclassified Verrucomicrobia 74201|Verrucomicrobia H Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate - - 2.7.9.2 ko:K01007 ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200 M00173,M00374 R00199 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - PEP-utilizers,PEP-utilizers_C,PPDK_N k59_941619_1 1219626.HMPREF1639_03395 1.75e-51 167.0 COG0197@1|root,COG0197@2|Bacteria,1V1AY@1239|Firmicutes,24FQX@186801|Clostridia,25RA4@186804|Peptostreptococcaceae 186801|Clostridia J Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs rplP - - ko:K02878 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L16 k59_433406_1 1144307.PMI04_04303 8.77e-07 48.9 COG0309@1|root,COG0309@2|Bacteria,1RDJ4@1224|Proteobacteria,2U7HE@28211|Alphaproteobacteria 28211|Alphaproteobacteria O COG3293 Transposase and inactivated derivatives - - - - - - - - - - - - DDE_Tnp_1,DDE_Tnp_1_2 k59_433406_2 1187851.A33M_1286 4.56e-68 208.0 COG3293@1|root,COG3293@2|Bacteria,1RDDI@1224|Proteobacteria,2UAE0@28211|Alphaproteobacteria,3FEDB@34008|Rhodovulum 28211|Alphaproteobacteria L Putative transposase of IS4/5 family (DUF4096) - - - ko:K07492 - - - - ko00000 - - - DUF4096 k59_720549_1 1229909.NSED_01800 1.58e-72 243.0 COG0495@1|root,arCOG00809@2157|Archaea,41SES@651137|Thaumarchaeota 651137|Thaumarchaeota J Belongs to the class-I aminoacyl-tRNA synthetase family leuS - 6.1.1.4 ko:K01869 ko00970,map00970 M00359,M00360 R03657 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - Anticodon_1,tRNA-synt_1 k59_1170603_1 981369.JQMJ01000004_gene650 1.69e-13 76.3 COG2272@1|root,COG2272@2|Bacteria,2GJCN@201174|Actinobacteria,2NE76@228398|Streptacidiphilus 201174|Actinobacteria I Carboxylesterase family pnbA - - ko:K03929 - - - - ko00000,ko01000 - CE10 - COesterase k59_42503_1 1116375.VEJY3_06585 1.4e-72 229.0 COG2040@1|root,COG2040@2|Bacteria,1MUXU@1224|Proteobacteria,1SBT6@1236|Gammaproteobacteria,1Y11R@135623|Vibrionales 135623|Vibrionales E Homocysteine S-methyltransferase - - - - - - - - - - - - S-methyl_trans k59_1569399_1 756272.Plabr_4227 1.12e-122 370.0 COG3829@1|root,COG3829@2|Bacteria,2J2D8@203682|Planctomycetes 203682|Planctomycetes KT Sigma-54 interaction domain - - - - - - - - - - - - HTH_8,PAS_10,PAS_4,PAS_9,Response_reg,Sigma54_activat k59_1569399_2 483219.LILAB_32090 5.86e-63 198.0 COG0605@1|root,COG0605@2|Bacteria,1MVW2@1224|Proteobacteria,42PC4@68525|delta/epsilon subdivisions,2WMG6@28221|Deltaproteobacteria,2YXXU@29|Myxococcales 28221|Deltaproteobacteria C Destroys radicals which are normally produced within the cells and which are toxic to biological systems sodB - 1.15.1.1 ko:K04564 ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016 - - - ko00000,ko00001,ko01000 - - - Sod_Fe_C,Sod_Fe_N k59_1676690_2 196490.AUEZ01000011_gene6360 1.17e-05 53.5 COG1028@1|root,COG1028@2|Bacteria,1R6D6@1224|Proteobacteria,2U672@28211|Alphaproteobacteria,3JS6Q@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria IQ Enoyl-(Acyl carrier protein) reductase - - - - - - - - - - - - adh_short_C2 k59_210081_1 1454004.AW11_01781 7.91e-84 259.0 COG0772@1|root,COG0772@2|Bacteria,1MUK3@1224|Proteobacteria,2VH8Q@28216|Betaproteobacteria,1KPW5@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria M Peptidoglycan polymerase that is essential for cell wall elongation mrdB - - ko:K05837 - - - - ko00000,ko03036 - - - FTSW_RODA_SPOVE k59_1734728_2 1278307.KB906973_gene1347 2.47e-52 187.0 COG2244@1|root,COG2244@2|Bacteria,1RIXW@1224|Proteobacteria,1SGVV@1236|Gammaproteobacteria,2QH91@267894|Psychromonadaceae 1236|Gammaproteobacteria S Membrane protein involved in the export of O-antigen and teichoic acid - - - - - - - - - - - - Polysacc_synt_3 k59_1450249_1 1439940.BAY1663_04267 8.9e-30 115.0 COG3642@1|root,COG3642@2|Bacteria,1N21R@1224|Proteobacteria,1RYF7@1236|Gammaproteobacteria 1236|Gammaproteobacteria T InaA protein inaA - - - - - - - - - - - Kdo k59_42524_1 234267.Acid_6852 2.86e-18 86.3 COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria 2|Bacteria U Involved in the tonB-independent uptake of proteins - - 2.7.11.1 ko:K08884,ko:K12132 - - - - ko00000,ko01000,ko01001 - - - PD40,Pkinase,WD40 k59_42524_2 1005999.GLGR_1103 4e-51 171.0 COG3132@1|root,COG3132@2|Bacteria,1RA13@1224|Proteobacteria,1RQUQ@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Belongs to the UPF0502 family yceH GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - ko:K09915 - - - - ko00000 - - - DUF480 k59_830308_2 1191523.MROS_0698 4.05e-87 271.0 COG3033@1|root,COG3033@2|Bacteria 2|Bacteria E tryptophanase activity tnaA - 4.1.99.1 ko:K01667 ko00380,map00380 - R00673 RC00209,RC00355 ko00000,ko00001,ko01000 - - - Beta_elim_lyase k59_489186_1 1121921.KB898719_gene69 1.51e-208 618.0 COG0086@1|root,COG0086@2|Bacteria,1MU3M@1224|Proteobacteria,1RPYH@1236|Gammaproteobacteria,2PMT9@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria K RNA polymerase I subunit A N-terminus rpoC GO:0000428,GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0030880,GO:0032774,GO:0032991,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234 2.7.7.6 ko:K03046 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5 k59_1174539_1 1280954.HPO_05737 1.84e-26 113.0 COG4772@1|root,COG4772@2|Bacteria,1QU2E@1224|Proteobacteria,2TWEM@28211|Alphaproteobacteria 28211|Alphaproteobacteria P TonB dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_1403687_1 316407.85675506 1.11e-64 222.0 COG3468@1|root,COG3468@2|Bacteria,1R9A8@1224|Proteobacteria,1RS0C@1236|Gammaproteobacteria,3XQQT@561|Escherichia 1236|Gammaproteobacteria MU cell adhesion ypjA - - - - - - - - - - - AIDA,Autotransporter,Pertactin k59_386736_1 715451.ambt_02245 3.77e-47 172.0 COG0653@1|root,COG0653@2|Bacteria,1MUJZ@1224|Proteobacteria,1RM9M@1236|Gammaproteobacteria,464S6@72275|Alteromonadaceae 1236|Gammaproteobacteria U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane secA GO:0000166,GO:0002790,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006457,GO:0006605,GO:0006810,GO:0006886,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0009306,GO:0009987,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032940,GO:0032991,GO:0033036,GO:0033220,GO:0034613,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042802,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0046903,GO:0046907,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0061077,GO:0065002,GO:0070727,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680 - ko:K03070 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4 - - SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW k59_611818_1 314278.NB231_05476 2.01e-89 278.0 COG0156@1|root,COG0156@2|Bacteria,1MVVH@1224|Proteobacteria,1RNS6@1236|Gammaproteobacteria,1WVW0@135613|Chromatiales 1236|Gammaproteobacteria H Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide - - - - - - - - - - - - Aminotran_1_2 k59_102404_1 485916.Dtox_1611 1.16e-43 153.0 COG0535@1|root,COG0535@2|Bacteria,1URM8@1239|Firmicutes,24XB8@186801|Clostridia 186801|Clostridia C 4Fe-4S single cluster domain - - - - - - - - - - - - Fer4_12,Radical_SAM,SPASM k59_1174544_1 1123401.JHYQ01000031_gene3394 2.69e-52 175.0 COG1714@1|root,COG1714@2|Bacteria,1RIE9@1224|Proteobacteria,1S566@1236|Gammaproteobacteria 1236|Gammaproteobacteria S membrane protein domain - - - - - - - - - - - - RDD k59_272151_1 247634.GPB2148_2838 6.42e-33 123.0 COG0491@1|root,COG0491@2|Bacteria,1MVC3@1224|Proteobacteria,1S25T@1236|Gammaproteobacteria 1236|Gammaproteobacteria L COG0491 Zn-dependent hydrolases, including glyoxylases blaB - 3.1.2.6 ko:K01069 ko00620,map00620 - R01736 RC00004,RC00137 ko00000,ko00001,ko01000 - - - Lactamase_B,NUDIX k59_1454520_3 67267.JNXT01000054_gene2979 5.94e-73 233.0 COG4653@1|root,COG4653@2|Bacteria 2|Bacteria G Phage capsid family - - - - - - - - - - - - Phage_capsid k59_1286001_2 441769.ABFU01000002_gene2966 4.21e-24 102.0 COG1428@1|root,COG1428@2|Bacteria,1TPJ1@1239|Firmicutes,4HA9N@91061|Bacilli,1ZBFB@1386|Bacillus 91061|Bacilli F Deoxycytidine kinase dck - 2.7.1.74,2.7.1.76 ko:K15519 ko00230,ko00240,ko01100,map00230,map00240,map01100 - R00185,R01666,R02089 RC00002,RC00017 ko00000,ko00001,ko01000 - - - dNK k59_1286001_3 70601.3258125 7.08e-11 65.5 COG0125@1|root,arCOG01891@2157|Archaea,2XTAM@28890|Euryarchaeota,242TV@183968|Thermococci 183968|Thermococci F thymidylate kinase tmk GO:0003674,GO:0003824,GO:0004798,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006227,GO:0006233,GO:0006235,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009165,GO:0009186,GO:0009189,GO:0009196,GO:0009197,GO:0009200,GO:0009202,GO:0009211,GO:0009212,GO:0009219,GO:0009221,GO:0009262,GO:0009263,GO:0009265,GO:0009394,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019692,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046072,GO:0046075,GO:0046077,GO:0046385,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.4.9 ko:K00943 ko00240,ko01100,map00240,map01100 M00053 R02094,R02098 RC00002 ko00000,ko00001,ko00002,ko01000 - - - Thymidylate_kin k59_1175634_1 1229909.NSED_04520 1.44e-105 315.0 arCOG03562@1|root,arCOG03562@2157|Archaea,41SY7@651137|Thaumarchaeota 651137|Thaumarchaeota O AhpC/TSA family - - - - - - - - - - - - AhpC-TSA k59_103638_1 316407.1736808 6.3e-126 365.0 COG1063@1|root,COG1063@2|Bacteria,1MXTX@1224|Proteobacteria,1RN1R@1236|Gammaproteobacteria,3XQPB@561|Escherichia 1236|Gammaproteobacteria E 5-dehydrogenase gatD GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006059,GO:0006066,GO:0008150,GO:0008152,GO:0008270,GO:0008868,GO:0009056,GO:0009987,GO:0016052,GO:0016491,GO:0016614,GO:0016616,GO:0019400,GO:0019402,GO:0019404,GO:0019405,GO:0019407,GO:0019751,GO:0042802,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044262,GO:0044275,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046164,GO:0046174,GO:0046872,GO:0046914,GO:0055114,GO:0071704,GO:1901575,GO:1901615,GO:1901616 1.1.1.251 ko:K00094 ko00052,ko01100,map00052,map01100 - R05571 RC00085 ko00000,ko00001,ko01000 - - iEC55989_1330.EC55989_2345,iECNA114_1301.ECNA114_2182,iECSF_1327.ECSF_1973,iYL1228.KPN_03551 ADH_N,ADH_zinc_N k59_1455712_1 702113.PP1Y_AT11408 5.79e-205 589.0 COG2010@1|root,COG4993@1|root,COG2010@2|Bacteria,COG4993@2|Bacteria,1R7EM@1224|Proteobacteria,2UPM6@28211|Alphaproteobacteria,2K9IJ@204457|Sphingomonadales 204457|Sphingomonadales C PQQ-like domain - - 1.1.9.1 ko:K17760 - - - - ko00000,ko01000 - - - Cytochrome_CBB3,PQQ k59_1792240_2 247634.GPB2148_321 2.37e-40 142.0 COG0625@1|root,COG0625@2|Bacteria 2|Bacteria O glutathione transferase activity - - 2.5.1.18 ko:K00799 ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418 - R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905 RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944 ko00000,ko00001,ko01000,ko02000 1.A.12.2.2,1.A.12.3.2 - - GST_C,GST_C_2,GST_N_3 k59_549977_1 1122137.AQXF01000006_gene696 4.79e-24 95.5 2E0PV@1|root,32W8K@2|Bacteria 2|Bacteria - - flbY - - - - - - - - - - - - k59_215286_1 641526.ADIWIN_1018 1.07e-91 291.0 COG4772@1|root,COG4772@2|Bacteria,4NEJW@976|Bacteroidetes,1HWWZ@117743|Flavobacteriia 976|Bacteroidetes P TonB-dependent receptor - - - - - - - - - - - - CarbopepD_reg_2,Plug,TonB_dep_Rec k59_1739925_1 702113.PP1Y_AT29646 3.87e-76 243.0 COG3104@1|root,COG3104@2|Bacteria,1MW6W@1224|Proteobacteria,2U15C@28211|Alphaproteobacteria,2K2WX@204457|Sphingomonadales 204457|Sphingomonadales E amino acid peptide transporter - - - ko:K03305 - - - - ko00000 2.A.17 - - PTR2 k59_387859_1 1306174.JODP01000006_gene3129 8.14e-11 62.0 COG0745@1|root,COG0745@2|Bacteria,2ISP7@201174|Actinobacteria 1306174.JODP01000006_gene3129|- KT cheY-homologous receiver domain - - - - - - - - - - - - - k59_387859_2 215803.DB30_2239 3.59e-32 126.0 COG4251@1|root,COG4251@2|Bacteria,1NSQ1@1224|Proteobacteria,42S0X@68525|delta/epsilon subdivisions,2WNBW@28221|Deltaproteobacteria 28221|Deltaproteobacteria T sensor histidine kinase - - - - - - - - - - - - HATPase_c,HisKA k59_1574744_1 1123487.KB892841_gene4230 9.17e-61 207.0 COG0187@1|root,COG0187@2|Bacteria,1MVH1@1224|Proteobacteria,2VHBQ@28216|Betaproteobacteria,2KUY6@206389|Rhodocyclales 206389|Rhodocyclales L Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule parE - - ko:K02622 - - - - ko00000,ko01000,ko02048,ko03032,ko03036 - - - DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim k59_273300_1 420324.KI911970_gene1564 4.21e-84 271.0 28HMZ@1|root,2Z7WD@2|Bacteria,1MU3Q@1224|Proteobacteria,2TSGX@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Protein of unknown function (DUF3604) - - - - - - - - - - - - DUF3604 k59_1116999_1 316407.1742225 4.37e-55 177.0 COG1484@1|root,COG1484@2|Bacteria,1R4QQ@1224|Proteobacteria,1RYGZ@1236|Gammaproteobacteria,3XM2M@561|Escherichia 1236|Gammaproteobacteria A DNA strand elongation ydaV GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0022616,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901576 - ko:K02315,ko:K10762 - - - - ko00000,ko03032 - - - IstB_IS21 k59_1116999_2 316407.85674925 5.41e-57 180.0 COG1846@1|root,COG1846@2|Bacteria 2|Bacteria K DNA-binding transcription factor activity - - - - - - - - - - - - DUF1627,HTH_24 k59_387872_1 436308.Nmar_1240 2.72e-30 113.0 COG1712@1|root,arCOG00254@2157|Archaea,41SGA@651137|Thaumarchaeota 651137|Thaumarchaeota H Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate nadX - 1.4.1.21 ko:K06989 ko00760,ko01100,map00760,map01100 - R07407,R07410 RC02566 ko00000,ko00001,ko01000 - - - DUF108,NAD_binding_3 k59_1792267_2 1386089.N865_12195 2.5e-45 150.0 COG0251@1|root,COG0251@2|Bacteria,2IIB2@201174|Actinobacteria,4FHUK@85021|Intrasporangiaceae 201174|Actinobacteria J Endoribonuclease L-PSP - - - - - - - - - - - - Ribonuc_L-PSP k59_665234_1 452637.Oter_1514 7.08e-58 187.0 COG1136@1|root,COG1136@2|Bacteria,46YZ8@74201|Verrucomicrobia,3K9FX@414999|Opitutae 414999|Opitutae P PFAM ABC transporter related - - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_1231647_1 762211.BSTEL_1117 2.91e-07 56.2 COG3247@1|root,COG3247@2|Bacteria,2H3AT@201174|Actinobacteria,4D00R@85004|Bifidobacteriales 201174|Actinobacteria S Short repeat of unknown function (DUF308) - - - - - - - - - - - - DUF308 k59_215300_1 545264.KB898744_gene2233 1.04e-21 92.8 COG3954@1|root,COG3954@2|Bacteria,1MWN9@1224|Proteobacteria,1RMS7@1236|Gammaproteobacteria,1WWCG@135613|Chromatiales 135613|Chromatiales C PFAM Phosphoribulokinase uridine kinase - - 2.7.1.19 ko:K00855 ko00710,ko01100,ko01120,ko01200,map00710,map01100,map01120,map01200 M00165,M00166 R01523 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - PRK k59_331023_1 631362.Thi970DRAFT_02439 2.94e-134 419.0 COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,1MU7B@1224|Proteobacteria,1RN2W@1236|Gammaproteobacteria,1WWAR@135613|Chromatiales 135613|Chromatiales E glutamate synthase - - 1.4.1.13,1.4.1.14 ko:K00265 ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 - R00093,R00114,R00248 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - GATase_2,GXGXG,Glu_syn_central,Glu_synthase k59_47681_2 765913.ThidrDRAFT_3989 1.03e-31 117.0 COG1863@1|root,COG1863@2|Bacteria,1N7MB@1224|Proteobacteria,1SCQX@1236|Gammaproteobacteria,1WYUR@135613|Chromatiales 135613|Chromatiales P PFAM cation antiporter - - - ko:K05569 - - - - ko00000,ko02000 2.A.63.1,2.A.63.2 - - MNHE k59_550003_1 1042377.AFPJ01000028_gene2180 8.83e-94 282.0 COG0031@1|root,COG0031@2|Bacteria,1MUBE@1224|Proteobacteria,1RN6J@1236|Gammaproteobacteria,4641I@72275|Alteromonadaceae 1236|Gammaproteobacteria E Belongs to the cysteine synthase cystathionine beta- synthase family cysK - 2.5.1.47 ko:K01738 ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230 M00021 R00897,R03601,R04859 RC00020,RC02814,RC02821 ko00000,ko00001,ko00002,ko01000 - - - PALP k59_1117018_1 349521.HCH_06139 1.72e-97 303.0 COG0464@1|root,COG0464@2|Bacteria,1MW4T@1224|Proteobacteria,1RPUI@1236|Gammaproteobacteria,1XHBD@135619|Oceanospirillales 135619|Oceanospirillales O COG0464 ATPases of the AAA class - - - - - - - - - - - - AAA k59_1517377_1 1415778.JQMM01000001_gene816 7.6e-20 87.8 COG3852@1|root,COG3852@2|Bacteria,1MVN6@1224|Proteobacteria,1RN15@1236|Gammaproteobacteria,1J4NI@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T Signal transduction histidine kinase, nitrogen specific glnL GO:0000155,GO:0000160,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0004721,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0006464,GO:0006468,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016311,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0016787,GO:0016788,GO:0016791,GO:0018106,GO:0018193,GO:0018202,GO:0019222,GO:0019538,GO:0023014,GO:0023052,GO:0035556,GO:0036211,GO:0042578,GO:0042802,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0046777,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051716,GO:0065007,GO:0071704,GO:0140096,GO:1901564 2.7.13.3 ko:K07708 ko02020,map02020 M00497 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA,PAS,PAS_4 k59_1517377_2 1415778.JQMM01000001_gene815 3.4e-129 380.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,1J4KP@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains glnG GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - ko:K07712 ko02020,map02020 M00497 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_776533_1 1287276.X752_00190 5.46e-54 181.0 COG1319@1|root,COG1319@2|Bacteria,1RCRH@1224|Proteobacteria,2TU08@28211|Alphaproteobacteria,43PT0@69277|Phyllobacteriaceae 28211|Alphaproteobacteria C Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM xdhB - 1.2.5.3 ko:K03519 - - R11168 RC02800 ko00000,ko01000 - - - CO_deh_flav_C,FAD_binding_5 k59_550015_1 5297.GMQ_02228T0 3.66e-08 54.7 COG0596@1|root,2QPPY@2759|Eukaryota,38J2J@33154|Opisthokonta,3NZP5@4751|Fungi,3UZEN@5204|Basidiomycota,2YBXS@29000|Pucciniomycotina 4751|Fungi I Serine aminopeptidase, S33 - - 3.4.11.5 ko:K01259 ko00330,map00330 - R00135 - ko00000,ko00001,ko01000,ko01002 - - - Abhydrolase_1,Abhydrolase_4 k59_550015_2 1158146.KB907127_gene1707 2.62e-06 52.0 COG0560@1|root,COG0560@2|Bacteria,1N5H2@1224|Proteobacteria,1S897@1236|Gammaproteobacteria,1WYC2@135613|Chromatiales 135613|Chromatiales E haloacid dehalogenase-like hydrolase - - - - - - - - - - - - HAD k59_1286067_1 953739.SVEN_7065 7.08e-33 127.0 COG1120@1|root,COG1120@2|Bacteria,2GJ49@201174|Actinobacteria 201174|Actinobacteria HP abc transporter - - 3.6.3.34 ko:K02013 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.14 - - ABC_tran k59_726274_1 290397.Adeh_2579 6.85e-83 271.0 COG1009@1|root,COG1009@2|Bacteria,1MW2M@1224|Proteobacteria,42KZE@68525|delta/epsilon subdivisions,2WIPT@28221|Deltaproteobacteria,2YWE3@29|Myxococcales 28221|Deltaproteobacteria CP NADH-Ubiquinone oxidoreductase (complex I) chain 5 L domain protein nuoL-1 - 1.6.5.3 ko:K00341 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Proton_antipo_C,Proton_antipo_M,Proton_antipo_N k59_1739987_2 1122137.AQXF01000002_gene43 6.35e-30 115.0 COG5265@1|root,COG5265@2|Bacteria,1MWU5@1224|Proteobacteria,2U7S8@28211|Alphaproteobacteria 28211|Alphaproteobacteria O HPr kinase - - - - - - - - - - - - - k59_438914_1 62928.azo1472 9.74e-73 228.0 COG1212@1|root,COG1212@2|Bacteria,1MUUU@1224|Proteobacteria,2VINM@28216|Betaproteobacteria,2KU7X@206389|Rhodocyclales 206389|Rhodocyclales M Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria kdsB - 2.7.7.38 ko:K00979 ko00540,ko01100,map00540,map01100 M00063 R03351,R11396 RC00152,RC00910 ko00000,ko00001,ko00002,ko01000,ko01005 - - - CTP_transf_3 k59_103713_1 1424334.W822_13200 8.54e-14 74.7 2C0PG@1|root,330E3@2|Bacteria,1RA6M@1224|Proteobacteria,2VW6R@28216|Betaproteobacteria,3T495@506|Alcaligenaceae 28216|Betaproteobacteria S Domain of unknown function (DUF4136) - - - - - - - - - - - - DUF4136 k59_1064183_1 523791.Kkor_0252 4.2e-09 59.7 COG2264@1|root,COG2264@2|Bacteria,1MUPC@1224|Proteobacteria,1RNAR@1236|Gammaproteobacteria,1XHE4@135619|Oceanospirillales 135619|Oceanospirillales J Ribosomal protein L11 methyltransferase prmA - - ko:K02687 - - - - ko00000,ko01000,ko03009 - - - PrmA k59_215364_1 316407.85676520 8.46e-146 429.0 COG2982@1|root,COG2982@2|Bacteria,1MUAN@1224|Proteobacteria,1RNZM@1236|Gammaproteobacteria,3XN25@561|Escherichia 1236|Gammaproteobacteria M regulation of protein targeting yhjG GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0032386,GO:0032879,GO:0032880,GO:0033157,GO:0044464,GO:0050789,GO:0051049,GO:0051223,GO:0060341,GO:0065007,GO:0070201,GO:0071944,GO:0090087,GO:0090313,GO:1903533,GO:1903827,GO:1905475 - ko:K07290 - - - - ko00000 9.B.121 - - AsmA k59_438928_1 1521187.JPIM01000010_gene2148 2.93e-44 159.0 COG0012@1|root,COG0012@2|Bacteria,2G5UY@200795|Chloroflexi,376AC@32061|Chloroflexia 32061|Chloroflexia J ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner ychF - - ko:K06942 - - - - ko00000,ko03009 - - - MMR_HSR1,YchF-GTPase_C k59_387932_1 1463821.JOGR01000016_gene3590 4.72e-09 57.8 COG0334@1|root,COG0334@2|Bacteria,2GKXG@201174|Actinobacteria,4EY3B@85014|Glycomycetales 201174|Actinobacteria E Glutamate/Leucine/Phenylalanine/Valine dehydrogenase vdh GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 1.4.1.23 ko:K00271 ko00280,ko01100,ko01110,ko01130,map00280,map01100,map01110,map01130 - R01212,R01434 RC00036 ko00000,ko00001,ko01000 - - - ELFV_dehydrog,ELFV_dehydrog_N k59_387932_2 89187.ISM_07215 6.87e-15 71.6 COG1522@1|root,COG1522@2|Bacteria,1RAP6@1224|Proteobacteria,2U5FX@28211|Alphaproteobacteria,46PJB@74030|Roseovarius 28211|Alphaproteobacteria K Transcriptional regulator, AsnC family - - - ko:K05800 - - - - ko00000,ko03000 - - - AsnC_trans_reg,HTH_24,HTH_AsnC-type k59_158106_1 1229909.NSED_09895 2.39e-102 306.0 COG1679@1|root,arCOG04278@2157|Archaea,41SBC@651137|Thaumarchaeota 651137|Thaumarchaeota S Protein of unknown function (DUF521) - - - ko:K09123 - - - - ko00000 - - - DUF521 k59_1455795_1 1121937.AUHJ01000007_gene1838 2.16e-40 149.0 COG0845@1|root,COG0845@2|Bacteria,1PEVY@1224|Proteobacteria,1RPEQ@1236|Gammaproteobacteria,465PN@72275|Alteromonadaceae 1236|Gammaproteobacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - - - - - - - - - - Biotin_lipoyl_2,HlyD_3 k59_331079_1 314278.NB231_09883 7.5e-85 262.0 COG3551@1|root,COG3551@2|Bacteria,1MYJC@1224|Proteobacteria,1S8FM@1236|Gammaproteobacteria,1X1UW@135613|Chromatiales 135613|Chromatiales S Sulfotransferase family - - - - - - - - - - - - Sulfotransfer_3 k59_1002885_1 436308.Nmar_1265 5.81e-82 246.0 COG0494@1|root,arCOG01072@2157|Archaea,41STX@651137|Thaumarchaeota 651137|Thaumarchaeota L NUDIX domain - - - - - - - - - - - - NUDIX k59_1002888_1 1121287.AUMU01000006_gene3898 2.92e-12 67.4 COG3004@1|root,COG3004@2|Bacteria,4NFC4@976|Bacteroidetes,1HXXZ@117743|Flavobacteriia,3ZPM0@59732|Chryseobacterium 976|Bacteroidetes P ) H( ) antiporter that extrudes sodium in exchange for external protons nhaA - - ko:K03313 - - - - ko00000,ko02000 2.A.33.1 - - Na_H_antiport_1 k59_1002888_2 1198452.Jab_1c20440 6.94e-31 118.0 COG2334@1|root,COG2334@2|Bacteria,1MU2Q@1224|Proteobacteria,2VI9A@28216|Betaproteobacteria,4730X@75682|Oxalobacteraceae 28216|Betaproteobacteria F A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response srkA - - - - - - - - - - - APH k59_1627592_1 926569.ANT_03170 7.12e-95 291.0 COG0154@1|root,COG0154@2|Bacteria,2G5T0@200795|Chloroflexi 200795|Chloroflexi J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) gatA - 6.3.5.6,6.3.5.7 ko:K02433 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - Amidase k59_47773_2 717774.Marme_4142 1.07e-15 74.7 COG0745@1|root,COG0745@2|Bacteria,1MY2Z@1224|Proteobacteria,1RN41@1236|Gammaproteobacteria,1XHIV@135619|Oceanospirillales 135619|Oceanospirillales T phosphate regulon transcriptional regulatory protein PhoB phoB - - ko:K07657 ko02020,map02020 M00434 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Trans_reg_C k59_835958_1 765914.ThisiDRAFT_2315 2.17e-45 163.0 COG0187@1|root,COG1372@1|root,COG0187@2|Bacteria,COG1372@2|Bacteria,1MVKT@1224|Proteobacteria,1RNB2@1236|Gammaproteobacteria,1WVZ4@135613|Chromatiales 135613|Chromatiales L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrB - 5.99.1.3 ko:K02470 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim k59_1231722_1 1229909.NSED_00840 5.24e-26 108.0 arCOG10597@1|root,arCOG10597@2157|Archaea 1229909.NSED_00840|- O serine-type endopeptidase activity - - - - - - - - - - - - - k59_215429_1 59196.RICGR_1114 1.8e-67 211.0 COG0024@1|root,COG0024@2|Bacteria,1MU99@1224|Proteobacteria,1RMHN@1236|Gammaproteobacteria,1JD2Y@118969|Legionellales 118969|Legionellales E Metallopeptidase family M24 map - 3.4.11.18 ko:K01265 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M24 k59_1117089_1 243231.GSU0842 6.23e-50 181.0 COG3852@1|root,COG3852@2|Bacteria,1NTTH@1224|Proteobacteria,43BN0@68525|delta/epsilon subdivisions,2X702@28221|Deltaproteobacteria 28221|Deltaproteobacteria T Histidine kinase A domain protein - - - - - - - - - - - - HATPase_c,HisKA,PAS,PAS_4,PAS_9,Response_reg k59_665344_1 745718.JADT01000014_gene219 1.88e-110 345.0 COG4775@1|root,COG4775@2|Bacteria,4NE6Z@976|Bacteroidetes,1HWVA@117743|Flavobacteriia 976|Bacteroidetes M Outer membrane protein assembly yaeT - - ko:K07277 - - - - ko00000,ko02000,ko03029 1.B.33 - - Bac_surface_Ag,POTRA k59_1064213_1 1333998.M2A_0382 5.98e-55 189.0 COG3653@1|root,COG3653@2|Bacteria,1MWWY@1224|Proteobacteria,2TSZZ@28211|Alphaproteobacteria 28211|Alphaproteobacteria Q COG3653 N-acyl-D-aspartate D-glutamate deacylase MA20_22865 - - - - - - - - - - - Amidohydro_3 k59_494509_1 195253.Syn6312_0926 1.27e-77 243.0 COG0082@1|root,COG0082@2|Bacteria,1G12S@1117|Cyanobacteria,1GYWY@1129|Synechococcus 1117|Cyanobacteria E Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system aroC GO:0000166,GO:0003674,GO:0003824,GO:0004107,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0010181,GO:0016053,GO:0016829,GO:0016835,GO:0016838,GO:0019438,GO:0019752,GO:0032553,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050662,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 4.2.3.5 ko:K01736 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R01714 RC00586 ko00000,ko00001,ko00002,ko01000 - - iJN678.aroC Chorismate_synt k59_836005_1 338963.Pcar_2269 1.24e-63 210.0 COG3344@1|root,COG3344@2|Bacteria,1MVI1@1224|Proteobacteria,42RS8@68525|delta/epsilon subdivisions,2WND0@28221|Deltaproteobacteria,43T0M@69541|Desulfuromonadales 28221|Deltaproteobacteria L PFAM RNA-directed DNA polymerase (Reverse transcriptase) - - - - - - - - - - - - Cas_Cas1,GIIM,RVT_1 k59_1455852_1 272942.RCAP_rcc02248 1.57e-12 68.9 COG0667@1|root,COG0667@2|Bacteria,1MV2Y@1224|Proteobacteria,2TS02@28211|Alphaproteobacteria,1FBM9@1060|Rhodobacter 28211|Alphaproteobacteria C Aldo/keto reductase family - - - - - - - - - - - - Aldo_ket_red k59_1455852_2 1144305.PMI02_03484 3.85e-53 179.0 COG1804@1|root,COG1804@2|Bacteria,1R78X@1224|Proteobacteria,2U3GG@28211|Alphaproteobacteria,2K8YE@204457|Sphingomonadales 204457|Sphingomonadales C CoA-transferase family III - - - - - - - - - - - - CoA_transf_3 k59_843983_1 1242864.D187_006642 8.96e-14 77.4 COG0642@1|root,COG0745@1|root,COG0745@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,42M0Y@68525|delta/epsilon subdivisions,2X791@28221|Deltaproteobacteria 28221|Deltaproteobacteria T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - GAF_2,HATPase_c,HisKA,PAS_4,Response_reg k59_165966_1 366602.Caul_0444 5.1e-64 211.0 COG1454@1|root,COG1454@2|Bacteria,1RC9B@1224|Proteobacteria,2U6JQ@28211|Alphaproteobacteria 28211|Alphaproteobacteria C Iron-containing alcohol dehydrogenase - - - - - - - - - - - - Fe-ADH k59_843988_1 1122604.JONR01000001_gene1738 1.08e-60 201.0 COG0114@1|root,COG0114@2|Bacteria,1MUQI@1224|Proteobacteria,1RNUS@1236|Gammaproteobacteria,1X3ED@135614|Xanthomonadales 135614|Xanthomonadales C Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate fumC - 4.2.1.2 ko:K01679 ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04934,ko05200,ko05211,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200,map04934,map05200,map05211 M00009,M00011,M00173,M00376 R01082 RC00443 ko00000,ko00001,ko00002,ko01000 - - - FumaraseC_C,Lyase_1 k59_55661_2 314287.GB2207_07547 7.62e-22 94.0 COG4799@1|root,COG4799@2|Bacteria,1MVAX@1224|Proteobacteria,1RNV5@1236|Gammaproteobacteria,1J520@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria I COG4799 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) accD5 - - - - - - - - - - - Carboxyl_trans k59_1690667_1 243231.GSU1593 8.21e-83 268.0 COG1185@1|root,COG1185@2|Bacteria,1MVB9@1224|Proteobacteria,42MTZ@68525|delta/epsilon subdivisions,2WJCE@28221|Deltaproteobacteria,43TFC@69541|Desulfuromonadales 28221|Deltaproteobacteria J Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction pnp GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004654,GO:0005488,GO:0006139,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009892,GO:0009987,GO:0010468,GO:0010605,GO:0010629,GO:0016070,GO:0016071,GO:0016740,GO:0016772,GO:0016779,GO:0019222,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0060255,GO:0065007,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901361,GO:1901363,GO:1901575 2.7.7.8 ko:K00962 ko00230,ko00240,ko03018,map00230,map00240,map03018 M00394 R00437,R00438,R00439,R00440 RC02795 ko00000,ko00001,ko00002,ko01000,ko03016,ko03019 - - - KH_1,PNPase,RNase_PH,RNase_PH_C,S1 k59_55673_1 702113.PP1Y_AT32682 1.12e-24 103.0 COG1028@1|root,COG1028@2|Bacteria,1MWZE@1224|Proteobacteria,2U09J@28211|Alphaproteobacteria,2K3R9@204457|Sphingomonadales 204457|Sphingomonadales IQ Short chain dehydrogenase - - - - - - - - - - - - adh_short,adh_short_C2 k59_446808_1 1280668.ATVT01000009_gene406 8.43e-16 85.9 COG0272@1|root,COG0507@1|root,COG0272@2|Bacteria,COG0507@2|Bacteria,1TPZH@1239|Firmicutes,247R7@186801|Clostridia,4BXPN@830|Butyrivibrio 186801|Clostridia L DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity recD2 - 3.1.11.5 ko:K03581 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - AAA_30,HHH_4,HHH_5,UvrD_C_2 k59_1294074_1 575540.Isop_0183 5.06e-69 231.0 COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,2IXK8@203682|Planctomycetes 203682|Planctomycetes E Prolyl oligopeptidase family - - - - - - - - - - - - PD40,Peptidase_S9 k59_672971_1 136993.KB900626_gene1820 6.16e-21 97.1 COG4422@1|root,COG4422@2|Bacteria,1MXQI@1224|Proteobacteria,2TVMB@28211|Alphaproteobacteria 28211|Alphaproteobacteria S PFAM Gp37Gp68 family protein - - - - - - - - - - - - DUF5131 k59_954957_2 338963.Pcar_1260 4.89e-55 195.0 COG1519@1|root,COG1519@2|Bacteria,1MU9F@1224|Proteobacteria,42PCH@68525|delta/epsilon subdivisions,2WMQM@28221|Deltaproteobacteria,43TBC@69541|Desulfuromonadales 28221|Deltaproteobacteria M 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase) kdtA - 2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15 ko:K02527 ko00540,ko01100,map00540,map01100 M00060,M00080 R04658,R05074,R09763 RC00009,RC00077,RC00247 ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT30 - Glycos_transf_N k59_1463806_1 1229909.NSED_04480 2.83e-05 45.4 COG0469@1|root,arCOG04071@2157|Archaea,41SHB@651137|Thaumarchaeota 651137|Thaumarchaeota J Ribosomal protein L4 - - - ko:K02930 ko03010,map03010 M00177,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L4 k59_1463806_2 436308.Nmar_0809 3.59e-146 419.0 COG0087@1|root,arCOG04070@2157|Archaea,41SDN@651137|Thaumarchaeota 651137|Thaumarchaeota J ribosomal protein L3 - - - ko:K02906 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L3 k59_223118_1 649638.Trad_0638 5.83e-63 216.0 COG1132@1|root,COG1132@2|Bacteria,1WMBB@1297|Deinococcus-Thermus 2|Bacteria V COGs COG1132 ABC-type multidrug transport system ATPase and permease components - - - ko:K06147 - - - - ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran k59_1800024_1 278957.ABEA03000055_gene1005 5.1e-63 206.0 COG0153@1|root,COG0153@2|Bacteria,46V7W@74201|Verrucomicrobia,3K7TW@414999|Opitutae 414999|Opitutae G Belongs to the GHMP kinase family. GalK subfamily - - 2.7.1.6 ko:K00849 ko00052,ko00520,ko01100,map00052,map00520,map01100 M00554,M00632 R01092 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000,ko04147 - - - GHMP_kinases_C,GHMP_kinases_N,GalKase_gal_bdg k59_784366_1 1117319.PSPO_14628 4.12e-37 140.0 COG1506@1|root,COG1506@2|Bacteria,1P6E1@1224|Proteobacteria,1RPRK@1236|Gammaproteobacteria,2Q0HE@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria E COG1506 Dipeptidyl aminopeptidases acylaminoacyl-peptidases dpp4 - 3.4.14.5 ko:K01278 ko04974,map04974 - - - ko00000,ko00001,ko01000,ko01002,ko04090,ko04147 - - - DPPIV_N,Peptidase_S9 k59_1635416_1 1229909.NSED_07190 2.53e-14 71.6 COG0624@1|root,arCOG01107@2157|Archaea,41SAX@651137|Thaumarchaeota 651137|Thaumarchaeota E Catalyzes the release of L-lysine from LysW -gamma-L- lysine and the release of L-ornithine from LysW -L-ornithine lysK - - ko:K05831 ko00220,ko00300,ko01100,ko01210,ko01230,map00220,map00300,map01100,map01210,map01230 M00031,M00763 R09779,R10933 RC00064,RC00090 ko00000,ko00001,ko00002 - - - M20_dimer,Peptidase_M20 k59_1635416_2 436308.Nmar_1297 1.7e-162 462.0 COG1798@1|root,COG1849@1|root,arCOG01224@2157|Archaea,arCOG04161@2157|Archaea,41SC2@651137|Thaumarchaeota 651137|Thaumarchaeota H diphthine synthase - - 2.1.1.98 ko:K20215 - - R04481,R08468,R08469,R10306 RC00003,RC00190,RC01155,RC02136,RC02308 ko00000,ko01000 - - - DUF357,TP_methylase k59_1747626_1 1123399.AQVE01000038_gene1900 6.14e-05 45.4 COG1136@1|root,COG1136@2|Bacteria,1MVSQ@1224|Proteobacteria,1RMWK@1236|Gammaproteobacteria,460DG@72273|Thiotrichales 72273|Thiotrichales V Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner lolD - - ko:K09810 ko02010,map02010 M00255 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.125 - - ABC_tran k59_1747626_2 1163617.SCD_n01097 1.72e-80 254.0 COG4591@1|root,COG4591@2|Bacteria,1MVV7@1224|Proteobacteria,2VH7C@28216|Betaproteobacteria 28216|Betaproteobacteria M lipoprotein releasing system, transmembrane protein, LolC E family lolC - - ko:K09808 ko02010,map02010 M00255 - - ko00000,ko00001,ko00002,ko02000 3.A.1.125 - - FtsX,MacB_PCD k59_1463827_1 1415778.JQMM01000001_gene657 3.51e-52 183.0 COG1166@1|root,COG1166@2|Bacteria,1MU80@1224|Proteobacteria,1RP2J@1236|Gammaproteobacteria,1J5HU@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Catalyzes the biosynthesis of agmatine from arginine speA GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006525,GO:0006527,GO:0006576,GO:0006595,GO:0006596,GO:0006807,GO:0008150,GO:0008152,GO:0008792,GO:0009056,GO:0009058,GO:0009063,GO:0009064,GO:0009065,GO:0009308,GO:0009309,GO:0009445,GO:0009446,GO:0009987,GO:0016054,GO:0016829,GO:0016830,GO:0016831,GO:0019752,GO:0034641,GO:0042401,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044271,GO:0044281,GO:0044282,GO:0046395,GO:0071704,GO:0097164,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606 4.1.1.19 ko:K01585 ko00330,ko01100,map00330,map01100 M00133 R00566 RC00299 ko00000,ko00001,ko00002,ko01000 - - iAPECO1_1312.APECO1_3590,iE2348C_1286.E2348C_3191,iEC55989_1330.EC55989_3231,iECABU_c1320.ECABU_c32250,iECED1_1282.ECED1_3401,iECIAI1_1343.ECIAI1_3071,iECIAI39_1322.ECIAI39_3358,iECO103_1326.ECO103_3518,iECO26_1355.ECO26_4037,iECOK1_1307.ECOK1_3327,iECP_1309.ECP_2933,iECS88_1305.ECS88_3221,iECSE_1348.ECSE_3207,iECSF_1327.ECSF_2737,iECSP_1301.ECSP_3909,iECUMN_1333.ECUMN_3290,iECW_1372.ECW_m3198,iECs_1301.ECs3814,iEKO11_1354.EKO11_0788,iEcE24377_1341.EcE24377A_3281,iEcHS_1320.EcHS_A3096,iEcolC_1368.EcolC_0773,iG2583_1286.G2583_3597,iLF82_1304.LF82_2157,iNRG857_1313.NRG857_14440,iPC815.YPO0929,iSBO_1134.SBO_3051,iSDY_1059.SDY_3134,iSSON_1240.SSON_3092,iSbBS512_1146.SbBS512_E3371,iWFL_1372.ECW_m3198,iZ_1308.Z4283 Orn_Arg_deC_N k59_955003_1 1122137.AQXF01000006_gene894 1.06e-108 318.0 COG0024@1|root,COG0024@2|Bacteria,1MU99@1224|Proteobacteria,2TQTH@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Methionine aminopeptidase map - 3.4.11.18 ko:K01265 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M24 k59_621346_2 377629.TERTU_1449 2.4e-11 67.8 COG4104@1|root,COG4104@2|Bacteria,1N5GI@1224|Proteobacteria,1SB51@1236|Gammaproteobacteria,2PPPC@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria S PAAR repeat-containing protein - - - - - - - - - - - - - k59_501960_1 1121920.AUAU01000004_gene642 4.38e-116 356.0 COG3808@1|root,COG3808@2|Bacteria,3Y34E@57723|Acidobacteria 57723|Acidobacteria C Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force hppA - 3.6.1.1 ko:K15987 ko00190,map00190 - - - ko00000,ko00001,ko01000 3.A.10.1 - - H_PPase k59_223148_1 105559.Nwat_1199 6.88e-44 160.0 COG1213@1|root,COG2513@1|root,COG1213@2|Bacteria,COG2513@2|Bacteria,1N4VT@1224|Proteobacteria,1RY5Q@1236|Gammaproteobacteria,1X09Q@135613|Chromatiales 135613|Chromatiales C Phosphoenolpyruvate phosphomutase - - 5.4.2.9 ko:K01841 ko00440,ko01100,ko01120,ko01130,map00440,map01100,map01120,map01130 - R00661 RC02792 ko00000,ko00001,ko01000 - - - NTP_transf_3,PEP_mutase k59_55725_1 762376.AXYL_04367 2.82e-10 60.8 COG0156@1|root,COG0156@2|Bacteria,1MVVH@1224|Proteobacteria,2VH25@28216|Betaproteobacteria,3T2F2@506|Alcaligenaceae 28216|Betaproteobacteria H Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide bioF GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008710,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016740,GO:0016746,GO:0016747,GO:0017144,GO:0018130,GO:0019752,GO:0019842,GO:0030170,GO:0032787,GO:0034641,GO:0036094,GO:0042364,GO:0043167,GO:0043168,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0070279,GO:0071704,GO:0072330,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.3.1.47 ko:K00652 ko00780,ko01100,map00780,map01100 M00123,M00573,M00577 R03210,R10124 RC00004,RC00039,RC02725 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 k59_55725_2 366602.Caul_2876 1.94e-20 89.7 COG0132@1|root,COG0132@2|Bacteria,1RDRK@1224|Proteobacteria,2U5AJ@28211|Alphaproteobacteria,2KHEP@204458|Caulobacterales 204458|Caulobacterales H Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring bioD - 6.3.3.3 ko:K01935 ko00780,ko01100,map00780,map01100 M00123,M00573,M00577 R03182 RC00868 ko00000,ko00001,ko00002,ko01000 - - - AAA_26 k59_1525236_2 565045.NOR51B_2721 3.18e-33 118.0 COG0713@1|root,COG0713@2|Bacteria,1RH0S@1224|Proteobacteria,1S6FN@1236|Gammaproteobacteria,1J7C7@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoK GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016020,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0030964,GO:0032991,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0070469,GO:0070470,GO:0071704,GO:0071944,GO:0072521,GO:0098796,GO:0098797,GO:0098803,GO:1901135,GO:1901360,GO:1901564,GO:1902494,GO:1990204 1.6.5.3 ko:K00340 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q2 k59_1525236_3 1121374.KB891587_gene2991 5.87e-42 143.0 COG0839@1|root,COG0839@2|Bacteria,1MWJV@1224|Proteobacteria,1S65T@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Belongs to the complex I subunit 6 family nuoJ GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008137,GO:0008150,GO:0008152,GO:0016020,GO:0016021,GO:0016491,GO:0016651,GO:0016655,GO:0030964,GO:0031224,GO:0031226,GO:0032991,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0050136,GO:0055114,GO:0070469,GO:0070470,GO:0071944,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1990204 1.6.5.3 ko:K00339 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - e_coli_core.b2280,iAF1260.b2280,iAPECO1_1312.APECO1_4285,iB21_1397.B21_02165,iBWG_1329.BWG_2054,iE2348C_1286.E2348C_2420,iEC042_1314.EC042_2521,iEC55989_1330.EC55989_2524,iECABU_c1320.ECABU_c26120,iECBD_1354.ECBD_1381,iECB_1328.ECB_02205,iECDH10B_1368.ECDH10B_2442,iECDH1ME8569_1439.ECDH1ME8569_2217,iECD_1391.ECD_02205,iECED1_1282.ECED1_2744,iECH74115_1262.ECH74115_3419,iECIAI1_1343.ECIAI1_2354,iECIAI39_1322.ECIAI39_2427,iECNA114_1301.ECNA114_2370,iECO103_1326.ECO103_2744,iECO111_1330.ECO111_3028,iECO26_1355.ECO26_3268,iECOK1_1307.ECOK1_2513,iECP_1309.ECP_2319,iECS88_1305.ECS88_2427,iECSE_1348.ECSE_2537,iECSF_1327.ECSF_2157,iECSP_1301.ECSP_3154,iECUMN_1333.ECUMN_2619,iECW_1372.ECW_m2468,iECs_1301.ECs3164,iEKO11_1354.EKO11_1487,iETEC_1333.ETEC_2415,iEcDH1_1363.EcDH1_1377,iEcE24377_1341.EcE24377A_2573,iEcHS_1320.EcHS_A2429,iEcSMS35_1347.EcSMS35_2434,iEcolC_1368.EcolC_1372,iJO1366.b2280,iJR904.b2280,iLF82_1304.LF82_1547,iNRG857_1313.NRG857_11545,iSBO_1134.SBO_2313,iSDY_1059.SDY_2476,iSFV_1184.SFV_2347,iSF_1195.SF2356,iSFxv_1172.SFxv_2600,iSSON_1240.SSON_2337,iS_1188.S2491,iSbBS512_1146.SbBS512_E2656,iUMN146_1321.UM146_05415,iUMNK88_1353.UMNK88_2830,iUTI89_1310.UTI89_C2560,iWFL_1372.ECW_m2468,iY75_1357.Y75_RS11955,iZ_1308.Z3539,ic_1306.c2821 Oxidored_q3 k59_621353_1 1207055.C100_16875 4.06e-88 273.0 COG0477@1|root,COG2814@2|Bacteria,1R7DW@1224|Proteobacteria,2U4H7@28211|Alphaproteobacteria,2KCE8@204457|Sphingomonadales 204457|Sphingomonadales EGP Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 k59_1071950_1 1122599.AUGR01000007_gene1127 3.26e-30 115.0 COG1176@1|root,COG1176@2|Bacteria,1MVGM@1224|Proteobacteria,1RNNZ@1236|Gammaproteobacteria,1XHK5@135619|Oceanospirillales 135619|Oceanospirillales P binding-protein-dependent transport systems inner membrane component - - - ko:K11075 ko02010,map02010 M00300 - - ko00000,ko00001,ko00002,ko02000 3.A.1.11.2 - - BPD_transp_1 k59_1071950_2 1232683.ADIMK_0729 1.22e-30 116.0 COG1177@1|root,COG1177@2|Bacteria,1MVC5@1224|Proteobacteria,1RQB7@1236|Gammaproteobacteria,46461@72275|Alteromonadaceae 1236|Gammaproteobacteria P COG1177 ABC-type spermidine putrescine transport system, permease component II potI - - ko:K11074 ko02010,map02010 M00300 - - ko00000,ko00001,ko00002,ko02000 3.A.1.11.2 - - BPD_transp_1 k59_1690741_1 107636.JQNK01000009_gene3513 7.1e-107 323.0 COG3666@1|root,COG3666@2|Bacteria,1N3QR@1224|Proteobacteria,2TRXG@28211|Alphaproteobacteria,370BU@31993|Methylocystaceae 28211|Alphaproteobacteria L Transposase DDE domain - - - ko:K07487 - - - - ko00000 - - - DDE_Tnp_1,DDE_Tnp_1_6,DUF772 k59_734190_1 742743.HMPREF9453_00115 9.74e-12 72.0 COG0841@1|root,COG0841@2|Bacteria,1TQ03@1239|Firmicutes,4H20U@909932|Negativicutes 909932|Negativicutes V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_734192_1 426114.THI_1577 2.02e-75 236.0 COG0667@1|root,COG0667@2|Bacteria,1MU1S@1224|Proteobacteria,2VMYU@28216|Betaproteobacteria,1KK3T@119065|unclassified Burkholderiales 28216|Betaproteobacteria C Aldo/keto reductase family - - - ko:K19265 - - - - ko00000,ko01000 - - - Aldo_ket_red k59_673015_2 641112.ACOK01000090_gene1200 1.46e-35 130.0 COG4586@1|root,COG4586@2|Bacteria,1TP1N@1239|Firmicutes,247KC@186801|Clostridia,3WI32@541000|Ruminococcaceae 186801|Clostridia S AAA domain, putative AbiEii toxin, Type IV TA system - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_338986_1 1191523.MROS_2246 1.27e-10 64.7 COG1215@1|root,COG1215@2|Bacteria 2|Bacteria M transferase activity, transferring glycosyl groups - - - - - - - - - - - - Glyco_tranf_2_3,Glycos_transf_2 k59_1294149_1 1121921.KB898709_gene419 1.09e-67 229.0 COG4225@1|root,COG4225@2|Bacteria,1MU2J@1224|Proteobacteria,1RR65@1236|Gammaproteobacteria,2PN9M@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria S Domain of unknown function (DUF4861) - - - - - - - - - - - - DUF4861,Glyco_hydro_88 k59_1071971_2 1122915.AUGY01000014_gene2783 6.67e-26 107.0 COG1028@1|root,COG1028@2|Bacteria,1TPZ8@1239|Firmicutes,4HAMW@91061|Bacilli,274QP@186822|Paenibacillaceae 91061|Bacilli IQ KR domain - - - - - - - - - - - - adh_short_C2 k59_1071979_1 870187.Thini_3697 1.33e-48 171.0 COG0628@1|root,COG0628@2|Bacteria,1MW0B@1224|Proteobacteria,1RPVP@1236|Gammaproteobacteria,45ZYG@72273|Thiotrichales 72273|Thiotrichales S AI-2E family transporter - - - - - - - - - - - - AI-2E_transport k59_1463891_1 1081640.AGFU01000063_gene3756 1.24e-21 91.7 COG2908@1|root,COG2908@2|Bacteria,1MVKD@1224|Proteobacteria,2TSEB@28211|Alphaproteobacteria,2K0Q8@204457|Sphingomonadales 204457|Sphingomonadales S protein conserved in bacteria - - - - - - - - - - - - Metallophos,Metallophos_2 k59_1124765_1 1224318.DT73_16920 1.45e-32 129.0 COG0477@1|root,COG2814@2|Bacteria,1MW19@1224|Proteobacteria,1RMSZ@1236|Gammaproteobacteria 1236|Gammaproteobacteria EGP Major facilitator superfamily bcr GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006857,GO:0008150,GO:0015833,GO:0016020,GO:0022857,GO:0035442,GO:0035672,GO:0035673,GO:0042886,GO:0042887,GO:0042938,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071916,GO:0071944,GO:1904680 - ko:K07552 - - - - ko00000,ko02000 2.A.1.2 - - MFS_1 k59_1350112_1 1121887.AUDK01000026_gene1924 1.12e-34 130.0 2E209@1|root,32X8E@2|Bacteria,4NSHA@976|Bacteroidetes,1I4IB@117743|Flavobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_1463893_1 1323663.AROI01000020_gene764 1.97e-34 133.0 COG3243@1|root,COG3243@2|Bacteria,1MU68@1224|Proteobacteria,1RPVQ@1236|Gammaproteobacteria 1236|Gammaproteobacteria I poly(R)-hydroxyalkanoic acid synthase phaC1 - - ko:K03821 ko00650,map00650 - R04254 RC00004 ko00000,ko00001,ko01000 - - - Abhydrolase_1,PhaC_N k59_1124770_1 335283.Neut_1298 7.69e-37 132.0 COG1214@1|root,COG1214@2|Bacteria,1MXPH@1224|Proteobacteria,2VQR7@28216|Betaproteobacteria,3732C@32003|Nitrosomonadales 28216|Betaproteobacteria O PFAM Peptidase M22, glycoprotease yeaZ - - ko:K14742 - - - - ko00000,ko03016 - - - Peptidase_M22 k59_1124774_1 1137281.D778_01979 8.5e-65 208.0 COG2890@1|root,COG2890@2|Bacteria,4PM1Z@976|Bacteroidetes,1I0P1@117743|Flavobacteriia 976|Bacteroidetes J O-methyltransferase - - - - - - - - - - - - Methyltransf_2 k59_557924_1 511145.b2479 8.7e-45 149.0 COG2716@1|root,COG2716@2|Bacteria,1R7W7@1224|Proteobacteria,1RSDP@1236|Gammaproteobacteria,3XN0Y@561|Escherichia 1236|Gammaproteobacteria K Negative transcriptional regulator of the glycine cleavage system operon (GCV). Does not autoregulate its own expression. It is not yet known how GcvR acts as a repressor. It does not seem to bind DNA. It could interact with GcvA and suppress its activatory activity gcvR GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576 - ko:K03567 ko02026,map02026 - - - ko00000,ko00001,ko03000 - - - ACT,ACT_6 k59_557924_2 316407.1799908 2.29e-87 257.0 COG1225@1|root,COG1225@2|Bacteria,1RD4R@1224|Proteobacteria,1RQ7F@1236|Gammaproteobacteria,3XNFY@561|Escherichia 1236|Gammaproteobacteria O Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events bcp GO:0003674,GO:0003824,GO:0004601,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008379,GO:0009636,GO:0009987,GO:0016209,GO:0016491,GO:0016667,GO:0016671,GO:0016684,GO:0032843,GO:0042221,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716,GO:0051920,GO:0055114,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1990748 1.11.1.15 ko:K03564 - - - - ko00000,ko01000 - - iPC815.YPO3064 AhpC-TSA k59_1010492_1 1123257.AUFV01000015_gene3633 1.7e-20 96.3 COG3170@1|root,COG3170@2|Bacteria,1QDEM@1224|Proteobacteria,1S884@1236|Gammaproteobacteria 1236|Gammaproteobacteria NU Protein of unknown function (DUF1207) - - - - - - - - - - - - DUF1207 k59_1800143_1 1173028.ANKO01000195_gene5985 2.17e-25 113.0 COG2202@1|root,COG2203@1|root,COG2905@1|root,COG3920@1|root,COG2202@2|Bacteria,COG2203@2|Bacteria,COG2905@2|Bacteria,COG3920@2|Bacteria,1GHCI@1117|Cyanobacteria,1H8J3@1150|Oscillatoriales 1117|Cyanobacteria T PFAM Signal transduction histidine kinase, subgroup 2, dimerisation and phosphoacceptor domain - - - - - - - - - - - - CBS,GAF,HATPase_c,HisKA_2,PAS,PAS_3,PAS_4,PAS_9 k59_784473_1 864069.MicloDRAFT_00013560 3.96e-22 100.0 28JZQ@1|root,2Z9PN@2|Bacteria,1N2WN@1224|Proteobacteria,2U0QD@28211|Alphaproteobacteria,1JQRW@119045|Methylobacteriaceae 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_784473_2 103733.JNYO01000042_gene6060 2.18e-31 124.0 28JDP@1|root,2Z97Z@2|Bacteria,2I9EC@201174|Actinobacteria,4E6WC@85010|Pseudonocardiales 201174|Actinobacteria - - - - - - - - - - - - - - - k59_1800145_1 391587.KAOT1_15928 2.74e-115 365.0 COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,4NFKH@976|Bacteroidetes,1HYB0@117743|Flavobacteriia 976|Bacteroidetes E Glutamate synthase gltB - 1.4.1.13,1.4.1.14,1.4.7.1 ko:K00265,ko:K00284 ko00250,ko00630,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00630,map00910,map01100,map01110,map01120,map01130,map01230 - R00021,R00093,R00114,R00248,R10086 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - GATase_2,GXGXG,Glu_syn_central,Glu_synthase k59_1801334_1 1056820.KB900630_gene1392 1.84e-31 113.0 COG0607@1|root,COG0607@2|Bacteria,1RHVM@1224|Proteobacteria,1SD9C@1236|Gammaproteobacteria,2PNZC@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria P Rhodanese Homology Domain pspE GO:0003674,GO:0003824,GO:0004792,GO:0005575,GO:0005623,GO:0016740,GO:0016782,GO:0016783,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0044464 - ko:K03972 - - - - ko00000 - - iE2348C_1286.E2348C_1500,iECABU_c1320.ECABU_c15910,iSDY_1059.SDY_1936,ic_1306.c1779 Rhodanese k59_1801334_2 247633.GP2143_15681 5.18e-23 95.5 COG0169@1|root,COG0169@2|Bacteria,1MVH4@1224|Proteobacteria,1RPB7@1236|Gammaproteobacteria,1J5D3@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) aroE GO:0000166,GO:0003674,GO:0003824,GO:0004764,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019632,GO:0019752,GO:0032787,GO:0036094,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0097159,GO:1901265,GO:1901363,GO:1901576,GO:1901615 1.1.1.25 ko:K00014 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02413 RC00206 ko00000,ko00001,ko00002,ko01000 - - iAPECO1_1312.APECO1_3165,iECOK1_1307.ECOK1_3701,iECS88_1305.ECS88_3669,iECUMN_1333.ECUMN_3755,iSBO_1134.SBO_3275,iUMN146_1321.UM146_16315,iUTI89_1310.UTI89_C3726 Shikimate_DH,Shikimate_dh_N k59_448040_1 981369.JQMJ01000004_gene3064 4.05e-09 59.3 COG0463@1|root,COG1887@1|root,COG0463@2|Bacteria,COG1887@2|Bacteria,2GM0T@201174|Actinobacteria,2NFYG@228398|Streptacidiphilus 201174|Actinobacteria M Glycosyltransferase like family 2 - - - - - - - - - - - - Glycos_transf_2,Glyphos_transf k59_448040_2 1122963.AUHB01000004_gene3090 9.38e-25 95.9 COG0271@1|root,COG0271@2|Bacteria,1MZG5@1224|Proteobacteria,2UF6U@28211|Alphaproteobacteria,36YZ7@31993|Methylocystaceae 28211|Alphaproteobacteria T BolA-like protein bolA GO:0006807,GO:0008150,GO:0008152,GO:0010467,GO:0019538,GO:0043170,GO:0044238,GO:0051604,GO:0071704,GO:0097428,GO:0106035,GO:1901564 - ko:K05527,ko:K22066 - - - - ko00000,ko03000,ko03029 - - - BolA k59_448040_3 426355.Mrad2831_3698 1.38e-55 182.0 COG0714@1|root,COG0714@2|Bacteria,1MXIW@1224|Proteobacteria,2TS1Z@28211|Alphaproteobacteria,1JRX3@119045|Methylobacteriaceae 28211|Alphaproteobacteria S PFAM ATPase associated with various cellular activities AAA_5 cobS - 6.6.1.2 ko:K09882 ko00860,ko01100,map00860,map01100 - R05227 RC02000 ko00000,ko00001,ko01000 - - - AAA_5,CbbQ_C,CobS_N k59_1801342_1 768066.HELO_3232 1.19e-47 162.0 COG3707@1|root,COG3707@2|Bacteria,1MXDV@1224|Proteobacteria,1S3YY@1236|Gammaproteobacteria,1XJT0@135619|Oceanospirillales 135619|Oceanospirillales T response regulator nasT - - ko:K07183 - - - - ko00000,ko02022 - - - ANTAR,Response_reg k59_1801342_2 316055.RPE_1266 4.49e-67 218.0 COG0715@1|root,COG0715@2|Bacteria,1MWDN@1224|Proteobacteria,2TS0X@28211|Alphaproteobacteria,3JSRI@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria P NMT1-like family MA20_13115 - - ko:K15576,ko:K22067 ko00910,ko02010,map00910,map02010 M00438 - - ko00000,ko00001,ko00002,ko02000,ko02022 3.A.1.16.1,3.A.1.16.2 - - NMT1_2 k59_224517_1 713586.KB900536_gene2578 1.81e-59 195.0 COG2805@1|root,COG2805@2|Bacteria,1MU3J@1224|Proteobacteria,1RN8G@1236|Gammaproteobacteria,1WWZV@135613|Chromatiales 135613|Chromatiales NU PFAM Type II secretion system protein E - - - - - - - - - - - - T2SSE k59_224517_2 1408445.JHXP01000010_gene2111 3.72e-17 82.8 COG2805@1|root,COG2805@2|Bacteria,1MU3J@1224|Proteobacteria,1RN8G@1236|Gammaproteobacteria,1JCBU@118969|Legionellales 118969|Legionellales NU Type II/IV secretion system protein yggR - - ko:K02669 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE k59_167317_1 1410630.JNKP01000003_gene1416 3.41e-18 89.0 COG1472@1|root,COG1472@2|Bacteria,1TP63@1239|Firmicutes,24YIP@186801|Clostridia,27IFR@186928|unclassified Lachnospiraceae 186801|Clostridia G Glycosyl hydrolase family 3 N terminal domain - - 3.2.1.52 ko:K01207 ko00520,ko00531,ko01100,ko01501,map00520,map00531,map01100,map01501 M00628 R00022,R05963,R07809,R07810,R10831 RC00049 ko00000,ko00001,ko00002,ko01000 - - - Glyco_hydro_3 k59_167317_2 1122139.KB907877_gene3034 2.39e-16 83.6 COG0591@1|root,COG0591@2|Bacteria,1QUXM@1224|Proteobacteria,1T251@1236|Gammaproteobacteria,1XJTT@135619|Oceanospirillales 135619|Oceanospirillales E Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family - - - ko:K03307 - - - - ko00000 2.A.21 - - SSF k59_845440_1 1128427.KB904821_gene3269 4.43e-07 53.9 COG4402@1|root,COG4402@2|Bacteria,1G1RZ@1117|Cyanobacteria,1H7X3@1150|Oscillatoriales 1117|Cyanobacteria S protein conserved in bacteria - - - - - - - - - - - - DUF2330 k59_845440_2 159087.Daro_4058 5.17e-22 94.7 COG1805@1|root,COG1805@2|Bacteria,1R88C@1224|Proteobacteria,2W2EH@28216|Betaproteobacteria 28216|Betaproteobacteria U NQR2, RnfD, RnfE family - - - - - - - - - - - - NQR2_RnfD_RnfE k59_1351389_1 1379270.AUXF01000002_gene1248 6.63e-41 155.0 COG0154@1|root,COG0154@2|Bacteria 2|Bacteria J amidase activity - - - ko:K21801 ko00380,ko01100,map00380,map01100 - - - ko00000,ko00001,ko01000 - - - Amidase k59_1692119_1 1117647.M5M_14857 4.84e-79 242.0 2EWBC@1|root,33PQ3@2|Bacteria,1NTC1@1224|Proteobacteria,1SJKD@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_224554_2 245174.XP_009269508.1 1.56e-30 123.0 COG0107@1|root,KOG0623@2759|Eukaryota,38J63@33154|Opisthokonta,3NUBP@4751|Fungi,3UZ6W@5204|Basidiomycota 4751|Fungi E Belongs to the HisA HisF family HIS7 GO:0000105,GO:0000107,GO:0003674,GO:0003824,GO:0004359,GO:0005575,GO:0005622,GO:0005623,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0016787,GO:0016810,GO:0016811,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 3.5.4.12 ko:K01493,ko:K01663 ko00240,ko00340,ko01100,ko01110,ko01230,map00240,map00340,map01100,map01110,map01230 M00026,M00429 R01663,R04558 RC00010,RC00074,RC01190,RC01943 ko00000,ko00001,ko00002,ko01000,ko02044 - - - GATase,His_biosynth k59_60047_1 1229909.NSED_03435 7.6e-120 347.0 COG1635@1|root,arCOG00574@2157|Archaea,41SDJ@651137|Thaumarchaeota 651137|Thaumarchaeota G Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur thi4 - - ko:K03146 ko00730,ko01100,map00730,map01100 - R10685 RC00033,RC03253,RC03254 ko00000,ko00001 - - - Thi4 k59_794383_1 1323663.AROI01000004_gene2153 2.06e-90 278.0 COG0438@1|root,COG0438@2|Bacteria,1NE3V@1224|Proteobacteria,1RQE3@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Catalyzes the addition of the first glucose residue to the LPS core rfaG GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008194,GO:0008610,GO:0008653,GO:0008919,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033692,GO:0034637,GO:0034645,GO:0035251,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0046401,GO:0046527,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 - ko:K02844 ko00540,ko01100,map00540,map01100 M00080 - - ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT4 iSDY_1059.SDY_4061 Glyco_transf_4,Glycos_transf_1 k59_1698050_1 1415778.JQMM01000001_gene158 1.12e-59 199.0 COG0617@1|root,COG0617@2|Bacteria,1MVCS@1224|Proteobacteria,1RMBG@1236|Gammaproteobacteria,1J4WJ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control pcnB GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0004652,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006276,GO:0006378,GO:0006396,GO:0006397,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016740,GO:0016772,GO:0016779,GO:0031123,GO:0031124,GO:0034641,GO:0043170,GO:0043412,GO:0043631,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070566,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363 2.7.7.19 ko:K00970 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - PolyA_pol,PolyA_pol_RNAbd,PolyA_pol_arg_C k59_1189618_1 316407.85674546 1.56e-157 447.0 COG0343@1|root,COG0343@2|Bacteria,1MUCA@1224|Proteobacteria,1RMY3@1236|Gammaproteobacteria,3XM9H@561|Escherichia 1236|Gammaproteobacteria F Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) tgt GO:0002097,GO:0002099,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008270,GO:0008479,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0034404,GO:0034470,GO:0034641,GO:0034654,GO:0034660,GO:0042455,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046116,GO:0046483,GO:0046872,GO:0046914,GO:0055086,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.4.2.29 ko:K00773 - - R03789,R10209 RC00063 ko00000,ko01000,ko03016 - - iECW_1372.ECW_m0475,iWFL_1372.ECW_m0475 TGT k59_1020511_1 436308.Nmar_0690 4.54e-43 149.0 COG2519@1|root,arCOG00978@2157|Archaea,41SEF@651137|Thaumarchaeota 651137|Thaumarchaeota Q tRNA methyltransferase complex GCD14 subunit - - 2.1.1.219,2.1.1.220 ko:K07442 - - - - ko00000,ko01000,ko03016 - - - GCD14 k59_1020511_2 436308.Nmar_0691 1.52e-111 327.0 COG0063@1|root,arCOG00018@2157|Archaea,41S8I@651137|Thaumarchaeota 651137|Thaumarchaeota G Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration nnrD - 4.2.1.136 ko:K17758 - - - - ko00000,ko01000 - - - Carb_kinase k59_229109_1 161528.ED21_22543 1.47e-33 125.0 COG0491@1|root,COG0491@2|Bacteria,1MURA@1224|Proteobacteria,2TR1F@28211|Alphaproteobacteria,2K06J@204457|Sphingomonadales 204457|Sphingomonadales S COG0491 Zn-dependent hydrolases, including glyoxylases - - - - - - - - - - - - Lactamase_B k59_229109_2 710421.Mycch_1475 5.29e-14 70.9 COG0450@1|root,COG0450@2|Bacteria,2GM74@201174|Actinobacteria,234SP@1762|Mycobacteriaceae 201174|Actinobacteria O Alkyl hydroperoxide reductase ahpC_1 - 1.11.1.15 ko:K03386 ko04214,map04214 - - - ko00000,ko00001,ko01000,ko04147 - - - 1-cysPrx_C,AhpC-TSA k59_1359243_1 331869.BAL199_29590 2.74e-23 97.8 COG0546@1|root,COG0546@2|Bacteria,1RDA7@1224|Proteobacteria,2U703@28211|Alphaproteobacteria,4BQR3@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria S HAD-hyrolase-like ppaX - 3.1.3.18 ko:K01091 ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130 - R01334 RC00017 ko00000,ko00001,ko01000 - - - HAD_2 k59_1359243_2 1122929.KB908228_gene4017 2.21e-07 51.6 COG0564@1|root,COG0564@2|Bacteria,1MVDX@1224|Proteobacteria,2TTQC@28211|Alphaproteobacteria 28211|Alphaproteobacteria J Responsible for synthesis of pseudouridine from uracil rluC GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360 5.4.99.24 ko:K06179 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2,S4 k59_455214_1 1038858.AXBA01000054_gene349 1.59e-77 245.0 COG2241@1|root,COG2242@1|root,COG2241@2|Bacteria,COG2242@2|Bacteria,1MVJX@1224|Proteobacteria,2TRR5@28211|Alphaproteobacteria,3EXWY@335928|Xanthobacteraceae 28211|Alphaproteobacteria H Tetrapyrrole (Corrin/Porphyrin) Methylases cobL - 2.1.1.132 ko:K00595 ko00860,ko01100,map00860,map01100 - R05149 RC00003,RC01279 ko00000,ko00001,ko01000 - - - PCMT,TP_methylase k59_568326_1 1122137.AQXF01000001_gene2794 3.92e-112 330.0 COG3143@1|root,COG3143@2|Bacteria,1MW23@1224|Proteobacteria,2TTS0@28211|Alphaproteobacteria 28211|Alphaproteobacteria NT chemotaxis protein - - - ko:K03414 ko02030,map02030 - - - ko00000,ko00001,ko02035 - - - CheZ k59_568326_2 1122137.AQXF01000001_gene2793 2.14e-81 241.0 COG0745@1|root,COG0745@2|Bacteria,1RDNP@1224|Proteobacteria,2U7BP@28211|Alphaproteobacteria 28211|Alphaproteobacteria KT Response regulator receiver QU41_12045 - - ko:K03413 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko02022,ko02035 - - - Response_reg k59_1641692_1 203122.Sde_0988 1.19e-65 220.0 COG1523@1|root,COG1523@2|Bacteria,1MU19@1224|Proteobacteria,1RP6F@1236|Gammaproteobacteria,464CN@72275|Alteromonadaceae 1236|Gammaproteobacteria G Belongs to the glycosyl hydrolase 13 family glgX - 3.2.1.41,3.2.1.68 ko:K01200,ko:K01214 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R02111,R09995,R11261 - ko00000,ko00001,ko00002,ko01000 - CBM48,GH13 - Alpha-amylase,CBM_48 k59_1076376_1 1515746.HR45_00915 5.04e-83 254.0 COG3507@1|root,COG3507@2|Bacteria,1QBSN@1224|Proteobacteria,1RNBA@1236|Gammaproteobacteria,2QBD4@267890|Shewanellaceae 1236|Gammaproteobacteria G Belongs to the glycosyl hydrolase 43 family - - - - - - - - - - - - AbfB,Glyco_hydro_43 k59_1076376_2 1123236.KB899383_gene2647 4.29e-31 118.0 COG3507@1|root,COG3507@2|Bacteria,1R3V6@1224|Proteobacteria,1RPI5@1236|Gammaproteobacteria,465M3@72275|Alteromonadaceae 1236|Gammaproteobacteria G Glycosyl hydrolases family 43 abnA - 3.2.1.99 ko:K06113 - - - - ko00000,ko01000 - GH43 - Glyco_hydro_43 k59_738063_1 1088721.NSU_2661 1.5e-63 203.0 COG0600@1|root,COG0600@2|Bacteria,1MU6Q@1224|Proteobacteria,2TQT6@28211|Alphaproteobacteria,2K6F9@204457|Sphingomonadales 204457|Sphingomonadales P Binding-protein-dependent transport system inner membrane component - - - ko:K15577 ko00910,ko02010,map00910,map02010 M00438 - - ko00000,ko00001,ko00002,ko02000 3.A.1.16.1,3.A.1.16.2 - - BPD_transp_1 k59_738063_2 1088721.NSU_2662 2.27e-52 179.0 COG1116@1|root,COG1116@2|Bacteria,1MUDV@1224|Proteobacteria,2TUIC@28211|Alphaproteobacteria,2K4DQ@204457|Sphingomonadales 204457|Sphingomonadales P ABC transporter - - - ko:K15578 ko00910,ko02010,map00910,map02010 M00438 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.16.1 - - ABC_tran k59_850789_1 1266925.JHVX01000007_gene2277 9.86e-06 54.3 COG0550@1|root,COG0550@2|Bacteria,1MUFZ@1224|Proteobacteria,2VHUF@28216|Betaproteobacteria,37271@32003|Nitrosomonadales 28216|Betaproteobacteria L DNA topoisomerase, type IA, central topB - 5.99.1.2 ko:K03169 - - - - ko00000,ko01000,ko03032 - - - SWIB,Topoisom_bac,Toprim,Toprim_Crpt k59_850789_2 886293.Sinac_3542 3.23e-19 85.9 COG0388@1|root,COG0388@2|Bacteria,2IX91@203682|Planctomycetes 203682|Planctomycetes S Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase - - 3.5.1.53 ko:K12251 ko00330,ko01100,map00330,map01100 - R01152 RC00096 ko00000,ko00001,ko01000 - - - CN_hydrolase k59_1585016_2 1382306.JNIM01000001_gene2592 1.03e-11 67.4 COG1028@1|root,COG1028@2|Bacteria,2G8S6@200795|Chloroflexi 200795|Chloroflexi IQ Enoyl-(Acyl carrier protein) reductase - - - - - - - - - - - - adh_short_C2 k59_3235_1 1298593.TOL_3456 3.04e-90 297.0 COG0086@1|root,COG0086@2|Bacteria,1MU3M@1224|Proteobacteria,1RPYH@1236|Gammaproteobacteria,1XH56@135619|Oceanospirillales 135619|Oceanospirillales K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoC - 2.7.7.6 ko:K03046 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5 k59_568335_1 553385.JEMF01000050_gene2151 1.07e-40 154.0 COG1643@1|root,COG1643@2|Bacteria,1MUEQ@1224|Proteobacteria,1RMU1@1236|Gammaproteobacteria,1XHUD@135619|Oceanospirillales 135619|Oceanospirillales L Involved in the post-transcriptional processing of the daa operon mRNA, which encodes proteins involved in fimbrial biogenesis of an enteropathogenic E. coli strain hrpA - 3.6.4.13 ko:K03578 - - - - ko00000,ko01000 - - - DEAD,DUF3418,HA2,Helicase_C,OB_NTP_bind k59_1698063_1 83406.HDN1F_16370 1.66e-12 70.1 COG1721@1|root,COG1721@2|Bacteria,1R3QD@1224|Proteobacteria,1S5F7@1236|Gammaproteobacteria,1J60U@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S conserved protein (some members contain a von Willebrand factor type A (vWA) domain) - - - - - - - - - - - - DUF58 k59_342492_1 1219080.VEZ01S_06_00140 8.41e-12 73.2 COG2911@1|root,COG2931@1|root,COG3210@1|root,COG2911@2|Bacteria,COG2931@2|Bacteria,COG3210@2|Bacteria,1MU7T@1224|Proteobacteria,1T35U@1236|Gammaproteobacteria,1Y2HG@135623|Vibrionales 135623|Vibrionales QU Parallel beta-helix repeats - - - - - - - - - - - - - k59_850805_1 1248760.ANFZ01000023_gene118 2.71e-28 108.0 COG3474@1|root,COG3474@2|Bacteria,1MZGS@1224|Proteobacteria,2UCUT@28211|Alphaproteobacteria,2K4M2@204457|Sphingomonadales 204457|Sphingomonadales C Cytochrome c - - - ko:K08738 ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416 M00595 R10151 RC03151,RC03152 ko00000,ko00001,ko00002 3.D.4.6 - - Cytochrom_C k59_738076_1 398720.MED217_13079 8.19e-45 157.0 2EKM2@1|root,33EAV@2|Bacteria,4NZ79@976|Bacteroidetes,1I8C7@117743|Flavobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_738076_2 398720.MED217_13084 7.98e-16 77.4 COG4249@1|root,COG4249@2|Bacteria,4NH9I@976|Bacteroidetes,1I151@117743|Flavobacteriia 976|Bacteroidetes S Caspase domain - - - - - - - - - - - - Peptidase_C14 k59_398844_1 1121912.AUHD01000006_gene1365 1.22e-111 328.0 COG1087@1|root,COG1087@2|Bacteria,4NEM9@976|Bacteroidetes,1HYSB@117743|Flavobacteriia 976|Bacteroidetes M UDP-glucose 4-epimerase galE - 5.1.3.2 ko:K01784 ko00052,ko00520,ko01100,map00052,map00520,map01100 M00361,M00362,M00632 R00291,R02984 RC00289 ko00000,ko00001,ko00002,ko01000 - - - Epimerase,GDP_Man_Dehyd k59_229122_1 981384.AEYW01000001_gene1612 3.58e-67 218.0 COG0161@1|root,COG0161@2|Bacteria,1MU2N@1224|Proteobacteria,2TQND@28211|Alphaproteobacteria,4N9XZ@97050|Ruegeria 28211|Alphaproteobacteria H Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family - - - - - - - - - - - - Aminotran_3 k59_3245_1 1337093.MBE-LCI_0141 1.52e-12 68.6 COG2968@1|root,COG2968@2|Bacteria,1RH7T@1224|Proteobacteria,2U981@28211|Alphaproteobacteria,2P9NQ@245186|Loktanella 28211|Alphaproteobacteria S Protein of unknown function (DUF541) omp28 GO:0005575,GO:0005623,GO:0042597,GO:0044464 - ko:K09807 - - - - ko00000 - - - SIMPL k59_3245_2 604331.AUHY01000092_gene997 5.21e-10 62.8 COG0517@1|root,COG0517@2|Bacteria,1WJ0F@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus S CBS domain - - - ko:K04767 - - - - ko00000 - - - ACT,CBS k59_116640_1 1122137.AQXF01000001_gene3250 1.9e-88 268.0 COG0169@1|root,COG0169@2|Bacteria,1MVH4@1224|Proteobacteria,2TS99@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) aroE - 1.1.1.25 ko:K00014 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02413 RC00206 ko00000,ko00001,ko00002,ko01000 - - - Shikimate_DH,Shikimate_dh_N k59_1302818_1 1131553.JIBI01000036_gene2040 3.13e-107 341.0 COG0550@1|root,COG0550@2|Bacteria,1MUFZ@1224|Proteobacteria,2VHUF@28216|Betaproteobacteria,37271@32003|Nitrosomonadales 28216|Betaproteobacteria L DNA topoisomerase, type IA, central topB - 5.99.1.2 ko:K03169 - - - - ko00000,ko01000,ko03032 - - - SWIB,Topoisom_bac,Toprim,Toprim_Crpt k59_1359270_1 1123248.KB893319_gene4061 1.03e-08 61.6 COG0457@1|root,COG2885@1|root,COG0457@2|Bacteria,COG2885@2|Bacteria,4NE6G@976|Bacteroidetes,1IPCG@117747|Sphingobacteriia 976|Bacteroidetes MU Belongs to the ompA family - - - - - - - - - - - - OmpA,PD40,TPR_16,TPR_2,TPR_8 k59_624701_1 1244869.H261_15452 2.49e-54 191.0 COG0664@1|root,COG1235@1|root,COG2703@1|root,COG0664@2|Bacteria,COG1235@2|Bacteria,COG2703@2|Bacteria,1R90N@1224|Proteobacteria,2TTTI@28211|Alphaproteobacteria,2JVDD@204441|Rhodospirillales 204441|Rhodospirillales PT COG1235 Metal-dependent hydrolases of the beta-lactamase superfamily I - - - - - - - - - - - - Hemerythrin,Lactamase_B_2,cNMP_binding k59_1359274_1 388401.RB2150_05233 7.89e-24 99.0 COG0406@1|root,COG0406@2|Bacteria,1NPC4@1224|Proteobacteria,2U9WD@28211|Alphaproteobacteria,3ZHVC@58840|unclassified Rhodobacteraceae 28211|Alphaproteobacteria G Belongs to the phosphoglycerate mutase family - - 5.4.2.12 ko:K15634 ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003 R01518 RC00536 ko00000,ko00001,ko00002,ko01000 - - - His_Phos_1 k59_850833_1 555793.WSK_0462 7.09e-110 331.0 COG0155@1|root,COG0155@2|Bacteria,1MVVB@1224|Proteobacteria,2TRCR@28211|Alphaproteobacteria,2K14A@204457|Sphingomonadales 204457|Sphingomonadales C Sulfite reductase cysI - 1.8.1.2 ko:K00381 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00176 R00858 RC00065 ko00000,ko00001,ko00002,ko01000 - - - NIR_SIR,NIR_SIR_ferr k59_850833_2 1096930.L284_14670 1.08e-75 228.0 COG3749@1|root,COG3749@2|Bacteria,1RJR9@1224|Proteobacteria,2UA02@28211|Alphaproteobacteria,2K4PM@204457|Sphingomonadales 204457|Sphingomonadales S protein conserved in bacteria - - - - - - - - - - - - DUF934 k59_1472197_1 523791.Kkor_1394 1.25e-15 80.9 COG0616@1|root,COG0616@2|Bacteria,1MUXE@1224|Proteobacteria,1RNYW@1236|Gammaproteobacteria,1XIQE@135619|Oceanospirillales 135619|Oceanospirillales OU peptidase - - - ko:K04773 - - - - ko00000,ko01000,ko01002 - - - Peptidase_S49 k59_1472197_2 502025.Hoch_2003 4.53e-61 201.0 COG2133@1|root,COG2133@2|Bacteria,1MVK5@1224|Proteobacteria,42MU3@68525|delta/epsilon subdivisions,2WKTF@28221|Deltaproteobacteria,2YV31@29|Myxococcales 28221|Deltaproteobacteria G Glucose / Sorbosone dehydrogenase - - - - - - - - - - - - GSDH k59_1246326_1 316407.85676516 2.64e-120 354.0 COG1301@1|root,COG1301@2|Bacteria,1MU0Q@1224|Proteobacteria,1RMEN@1236|Gammaproteobacteria,3XNK8@561|Escherichia 1236|Gammaproteobacteria C Responsible for the transport of dicarboxylates such as succinate, fumarate, and malate across the membrane dctA GO:0003333,GO:0003674,GO:0005215,GO:0005310,GO:0005326,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006835,GO:0006836,GO:0006855,GO:0006865,GO:0006950,GO:0006974,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015138,GO:0015140,GO:0015141,GO:0015171,GO:0015172,GO:0015179,GO:0015183,GO:0015238,GO:0015291,GO:0015293,GO:0015294,GO:0015295,GO:0015318,GO:0015366,GO:0015556,GO:0015672,GO:0015711,GO:0015740,GO:0015741,GO:0015743,GO:0015744,GO:0015800,GO:0015807,GO:0015849,GO:0015893,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0022890,GO:0031224,GO:0031226,GO:0033554,GO:0034220,GO:0042221,GO:0042493,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0051716,GO:0055085,GO:0070778,GO:0071422,GO:0071423,GO:0071702,GO:0071705,GO:0071944,GO:0098655,GO:0098656,GO:0098660,GO:0098662,GO:1902475,GO:1902600,GO:1903825,GO:1905039 - ko:K11103 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.23.1.3,2.A.23.1.6,2.A.23.1.7 - iSDY_1059.SDY_4548 SDF k59_1528701_1 648757.Rvan_0034 4.76e-68 217.0 COG1063@1|root,COG1063@2|Bacteria,1QTU5@1224|Proteobacteria,2TW9Q@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology yphC - 1.1.1.368 ko:K07538 ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220 M00541 R05581 RC00850 ko00000,ko00001,ko00002,ko01000 - - - ADH_N,ADH_N_assoc,ADH_zinc_N k59_3291_1 1089455.MOPEL_078_00910 9.81e-20 85.5 COG0315@1|root,COG0315@2|Bacteria,2IHR6@201174|Actinobacteria,4F6TD@85018|Dermatophilaceae 201174|Actinobacteria H Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP) moaC - 4.6.1.17 ko:K03637 ko00790,ko01100,ko04122,map00790,map01100,map04122 - R11372 RC03425 ko00000,ko00001,ko01000 - - - MoaC k59_3291_2 509190.Cseg_2554 2.01e-06 53.1 COG0741@1|root,COG0741@2|Bacteria,1MZ4X@1224|Proteobacteria,2U5GT@28211|Alphaproteobacteria,2KK2V@204458|Caulobacterales 204458|Caulobacterales M Transglycosylase SLT domain - - - - - - - - - - - - SLT k59_963655_2 298653.Franean1_7210 1.23e-119 365.0 COG0034@1|root,COG0034@2|Bacteria,2GK6I@201174|Actinobacteria,4ERIS@85013|Frankiales 201174|Actinobacteria F Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine purF GO:0008150,GO:0040007 2.4.2.14 ko:K00764 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048 R01072 RC00010,RC02724,RC02752 ko00000,ko00001,ko00002,ko01000,ko01002 - - - GATase_6,GATase_7,Pribosyltran k59_1416465_1 1125863.JAFN01000001_gene307 9.9e-67 216.0 COG0015@1|root,COG0015@2|Bacteria,1MV4B@1224|Proteobacteria,42MYS@68525|delta/epsilon subdivisions,2WJ2E@28221|Deltaproteobacteria 28221|Deltaproteobacteria F Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily purB - 4.3.2.2 ko:K01756 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048,M00049 R01083,R04559 RC00379,RC00444,RC00445 ko00000,ko00001,ko00002,ko01000 - - - ADSL_C,Lyase_1 k59_1021636_1 1229909.NSED_06185 4.37e-13 69.7 COG1530@1|root,arCOG00321@2157|Archaea,41T2C@651137|Thaumarchaeota 651137|Thaumarchaeota L modulator of DNA gyrase - - - ko:K03568 - - - - ko00000,ko01002 - - - PmbA_TldD k59_1021636_2 1229909.NSED_06180 3.61e-119 365.0 COG0642@1|root,arCOG02358@2157|Archaea 2157|Archaea T Histidine kinase - - - - - - - - - - - - CHASE4,HAMP,HATPase_c,HisKA,PAS_4,PAS_8,PAS_9,Response_reg,sCache_3_3 k59_682127_1 1122137.AQXF01000005_gene1124 2.98e-75 236.0 COG0404@1|root,COG0404@2|Bacteria,1MV96@1224|Proteobacteria,2TRN4@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Glycine cleavage system T protein gcvT GO:0001505,GO:0003674,GO:0003824,GO:0004047,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005960,GO:0006082,GO:0006520,GO:0006544,GO:0006546,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008483,GO:0009056,GO:0009063,GO:0009069,GO:0009071,GO:0009987,GO:0016054,GO:0016740,GO:0016741,GO:0016769,GO:0017144,GO:0019464,GO:0019752,GO:0032259,GO:0032991,GO:0042133,GO:0042135,GO:0042737,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0065007,GO:0065008,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606,GO:1902494,GO:1990204 2.1.2.10 ko:K00605 ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200 M00532 R01221,R02300,R04125 RC00022,RC00069,RC00183,RC02834 ko00000,ko00001,ko00002,ko01000 - - - GCV_T,GCV_T_C k59_682127_2 1500306.JQLA01000002_gene1483 2.26e-06 46.6 COG0509@1|root,COG0509@2|Bacteria,1RGV7@1224|Proteobacteria,2U9BY@28211|Alphaproteobacteria,4BEMJ@82115|Rhizobiaceae 28211|Alphaproteobacteria E The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein gcvH - - ko:K02437 ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200 M00532 R01221 RC00022,RC02834 ko00000,ko00001,ko00002 - - - GCV_H k59_1585977_1 1469557.JSWF01000046_gene185 1.27e-43 151.0 COG2608@1|root,COG2608@2|Bacteria,4NPHG@976|Bacteroidetes,1IJ2G@117743|Flavobacteriia 976|Bacteroidetes P Heavy-metal-associated domain - - - ko:K07213 ko04978,map04978 - - - ko00000,ko00001 - - - HMA k59_739151_1 1254432.SCE1572_05895 1.06e-87 281.0 COG0855@1|root,COG0855@2|Bacteria,1MUM3@1224|Proteobacteria,42NN7@68525|delta/epsilon subdivisions,2WJG7@28221|Deltaproteobacteria,2YUAP@29|Myxococcales 28221|Deltaproteobacteria H Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) ppk - 2.7.4.1 ko:K00937 ko00190,ko03018,map00190,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - PP_kinase,PP_kinase_C,PP_kinase_N k59_343619_1 177437.HRM2_16470 2.19e-80 263.0 COG2812@1|root,COG2812@2|Bacteria,1MVCK@1224|Proteobacteria,42M09@68525|delta/epsilon subdivisions,2WJ1G@28221|Deltaproteobacteria,2MHZQ@213118|Desulfobacterales 28221|Deltaproteobacteria L DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity dnaX - 2.7.7.7 ko:K02343 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_delta2,DNA_pol3_gamma3 k59_682138_1 1122137.AQXF01000002_gene502 8.96e-97 300.0 COG1154@1|root,COG1154@2|Bacteria,1MUSJ@1224|Proteobacteria,2TRDD@28211|Alphaproteobacteria 28211|Alphaproteobacteria H Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) dxs - 2.2.1.7 ko:K01662 ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130 M00096 R05636 RC00032 ko00000,ko00001,ko00002,ko01000 - - - DXP_synthase_N,Transket_pyr,Transketolase_C k59_1247252_1 436308.Nmar_0514 1.64e-102 305.0 COG0667@1|root,arCOG01617@2157|Archaea,41S90@651137|Thaumarchaeota 651137|Thaumarchaeota C Aldo/keto reductase family - - - - - - - - - - - - Aldo_ket_red k59_964748_2 41431.PCC8801_0198 9.72e-14 72.8 COG4638@1|root,COG4638@2|Bacteria,1G4PW@1117|Cyanobacteria,3KKBZ@43988|Cyanothece 1117|Cyanobacteria P Ring hydroxylating alpha subunit (catalytic domain) - - 1.14.15.7 ko:K00479,ko:K00499 ko00260,map00260 - R07409 RC00087 ko00000,ko00001,ko01000 - - - Rieske,Ring_hydroxyl_A k59_1360239_1 643473.KB235930_gene3195 8.21e-06 47.0 COG0520@1|root,COG0520@2|Bacteria,1G4XH@1117|Cyanobacteria,1HK8S@1161|Nostocales 1117|Cyanobacteria E TIGRFAM cysteine desulfurase family protein - - - - - - - - - - - - Aminotran_5 k59_1360239_2 1122604.JONR01000009_gene2409 4.14e-09 58.5 COG0462@1|root,COG0462@2|Bacteria,1MW21@1224|Proteobacteria,1RMUC@1236|Gammaproteobacteria,1X3Z0@135614|Xanthomonadales 135614|Xanthomonadales F Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) prs - 2.7.6.1 ko:K00948 ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230 M00005 R01049 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - Pribosyl_synth,Pribosyltran_N k59_964758_1 349521.HCH_01590 9.79e-125 382.0 COG1529@1|root,COG1529@2|Bacteria,1QTTJ@1224|Proteobacteria,1RNCM@1236|Gammaproteobacteria,1XN8J@135619|Oceanospirillales 135619|Oceanospirillales C Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain - - 1.3.99.16 ko:K07303 - - - - ko00000,ko01000 - - - Ald_Xan_dh_C,Ald_Xan_dh_C2 k59_964758_2 1048339.KB913029_gene3814 1.53e-14 77.0 COG0406@1|root,COG0406@2|Bacteria,2HUBQ@201174|Actinobacteria 201174|Actinobacteria G Phosphoglycerate mutase family - - 5.4.2.12 ko:K15634 ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003 R01518 RC00536 ko00000,ko00001,ko00002,ko01000 - - - His_Phos_1 k59_1416498_1 1247649.D560_0032 1.02e-42 144.0 COG0799@1|root,COG0799@2|Bacteria,1MZEF@1224|Proteobacteria,2VRRV@28216|Betaproteobacteria,3T45A@506|Alcaligenaceae 28216|Betaproteobacteria J Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation rsfS - - ko:K09710 - - - - ko00000,ko03009 - - - RsfS k59_4433_1 1131451.O1K_09042 2.77e-60 196.0 COG1946@1|root,COG1946@2|Bacteria,1MV9R@1224|Proteobacteria,1RPFI@1236|Gammaproteobacteria,1X38E@135614|Xanthomonadales 135614|Xanthomonadales I Acyl-CoA thioesterase tesB - - ko:K10805 ko01040,map01040 - - - ko00000,ko00001,ko01000,ko01004 - - - 4HBT_3 k59_174059_1 762903.Pedsa_3753 2.66e-06 56.6 COG4733@1|root,COG4733@2|Bacteria,4NINK@976|Bacteroidetes,1IX3J@117747|Sphingobacteriia 976|Bacteroidetes S SPTR GPI anchored protein - - - - - - - - - - - - Alginate_lyase,Laminin_G_3 k59_625714_1 596154.Alide2_3213 3.27e-60 194.0 COG0372@1|root,COG0372@2|Bacteria,1MUII@1224|Proteobacteria,2VWB8@28216|Betaproteobacteria,4AJA2@80864|Comamonadaceae 28216|Betaproteobacteria C Citrate synthase, C-terminal domain - - 2.3.3.1 ko:K01647 ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00740 R00351 RC00004,RC00067 br01601,ko00000,ko00001,ko00002,ko01000 - - - Citrate_synt k59_1529695_1 1479237.JMLY01000001_gene980 1.46e-70 225.0 COG0006@1|root,COG0006@2|Bacteria,1MVX5@1224|Proteobacteria,1RNY9@1236|Gammaproteobacteria,46C4E@72275|Alteromonadaceae 1236|Gammaproteobacteria E Metallopeptidase family M24 - - - - - - - - - - - - Creatinase_N,Peptidase_M24 k59_1473238_1 158500.BV97_05038 4.64e-89 273.0 COG1228@1|root,COG1228@2|Bacteria,1MVAF@1224|Proteobacteria,2TSAB@28211|Alphaproteobacteria,2K2RI@204457|Sphingomonadales 204457|Sphingomonadales Q Amidohydrolase family - - - - - - - - - - - - Amidohydro_1 k59_1473238_2 1096930.L284_02500 2.49e-18 82.8 COG0583@1|root,COG0583@2|Bacteria,1NC2E@1224|Proteobacteria,2UBBU@28211|Alphaproteobacteria,2K3SQ@204457|Sphingomonadales 204457|Sphingomonadales K Bacterial regulatory helix-turn-helix protein, lysR family - - - - - - - - - - - - HTH_1,LysR_substrate k59_343657_1 1088721.NSU_1227 1.48e-81 268.0 COG0823@1|root,COG1228@1|root,COG0823@2|Bacteria,COG1228@2|Bacteria,1MX3A@1224|Proteobacteria,2TUU6@28211|Alphaproteobacteria,2K0I3@204457|Sphingomonadales 204457|Sphingomonadales QU Periplasmic component of the Tol biopolymer transport system - - - - - - - - - - - - Amidohydro_1,PD40 k59_1247288_2 1229909.NSED_01600 2.69e-96 313.0 arCOG08778@1|root,arCOG08778@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_1473245_2 1415778.JQMM01000001_gene719 2.37e-13 72.0 COG0811@1|root,COG0811@2|Bacteria,1MX5J@1224|Proteobacteria,1RMSA@1236|Gammaproteobacteria,1J4VD@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria U MotA TolQ ExbB proton channel family protein - - - ko:K03561 - - - - ko00000,ko02000 1.A.30.2.1 - - MotA_ExbB k59_1360264_1 1380387.JADM01000004_gene2844 5.24e-81 253.0 COG0055@1|root,COG0055@2|Bacteria,1MUFU@1224|Proteobacteria,1RN6U@1236|Gammaproteobacteria,1XIMC@135619|Oceanospirillales 135619|Oceanospirillales C Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits atpD - 3.6.3.14 ko:K02112 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - - ATP-synt_ab,ATP-synt_ab_N k59_1134275_1 717773.Thicy_0919 2.32e-36 132.0 COG0546@1|root,COG0546@2|Bacteria,1R9XQ@1224|Proteobacteria,1S1Z0@1236|Gammaproteobacteria,46359@72273|Thiotrichales 72273|Thiotrichales S Haloacid dehalogenase-like hydrolase - - - - - - - - - - - - HAD_2 k59_1416516_1 1122612.AUBA01000015_gene888 2.12e-93 290.0 COG0277@1|root,COG0277@2|Bacteria,1MY08@1224|Proteobacteria,2U5D5@28211|Alphaproteobacteria,2K1C7@204457|Sphingomonadales 204457|Sphingomonadales C Protein involved in UDP-N-acetylmuramate dehydrogenase activity and amino sugar metabolic process - - 1.17.99.1 ko:K05797 ko00623,ko01100,ko01120,map00623,map01100,map01120 - R02675,R11194 RC00769 ko00000,ko00001,ko01000 - - - FAD-oxidase_C,FAD_binding_4 k59_512679_1 666681.M301_1701 1.47e-10 70.5 COG2202@1|root,COG2203@1|root,COG5000@1|root,COG5001@1|root,COG2202@2|Bacteria,COG2203@2|Bacteria,COG5000@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,2KMBP@206350|Nitrosomonadales 206350|Nitrosomonadales T PFAM EAL domain - - - - - - - - - - - - EAL,GAF_2,GGDEF,PAS_9 k59_569363_1 502025.Hoch_2351 1.24e-85 261.0 COG0491@1|root,COG0491@2|Bacteria,1MURA@1224|Proteobacteria,42P5T@68525|delta/epsilon subdivisions,2WM91@28221|Deltaproteobacteria,2Z2Z9@29|Myxococcales 28221|Deltaproteobacteria S Metallo-beta-lactamase superfamily - - - - - - - - - - - - Lactamase_B k59_1473271_1 264730.PSPPH_4195 1.64e-06 50.1 COG0149@1|root,COG0149@2|Bacteria,1MWK5@1224|Proteobacteria,1RM8I@1236|Gammaproteobacteria,1Z53A@136849|Pseudomonas syringae group 1236|Gammaproteobacteria F Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) tpiA GO:0003674,GO:0003824,GO:0004807,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006066,GO:0006071,GO:0006081,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0018130,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019400,GO:0019405,GO:0019438,GO:0019439,GO:0019563,GO:0019637,GO:0019682,GO:0019693,GO:0019751,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042802,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044262,GO:0044270,GO:0044271,GO:0044275,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046164,GO:0046166,GO:0046174,GO:0046184,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1901615,GO:1901616 5.3.1.1 ko:K01803 ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003 R01015 RC00423 ko00000,ko00001,ko00002,ko01000,ko04147 - - iJN746.PP_4715 TIM k59_1473271_2 1027273.GZ77_20955 3.48e-10 61.6 COG1109@1|root,COG1109@2|Bacteria,1MU24@1224|Proteobacteria,1RMR2@1236|Gammaproteobacteria,1XH2Q@135619|Oceanospirillales 135619|Oceanospirillales G Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate glmM - 5.4.2.10 ko:K03431 ko00520,ko01100,ko01130,map00520,map01100,map01130 - R02060 RC00408 ko00000,ko00001,ko01000 - - - PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV k59_1473272_1 63737.Npun_F1981 4.19e-29 109.0 COG0346@1|root,COG0346@2|Bacteria 2|Bacteria E lactoylglutathione lyase activity - - - - - - - - - - - - Glyoxalase,Glyoxalase_4 k59_1084283_1 1131266.ARWQ01000008_gene298 4.21e-24 106.0 COG0673@1|root,COG1241@1|root,arCOG00439@2157|Archaea,arCOG01622@2157|Archaea,41SA7@651137|Thaumarchaeota 651137|Thaumarchaeota L Belongs to the MCM family - - - ko:K10726 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - MCM,MCM_N,MCM_OB k59_1254114_1 243231.GSU2554 1.69e-34 121.0 COG3952@1|root,COG3952@2|Bacteria,1MZ60@1224|Proteobacteria,42V3D@68525|delta/epsilon subdivisions,2WS7J@28221|Deltaproteobacteria 28221|Deltaproteobacteria S PFAM lipid A biosynthesis domain protein - - - - - - - - - - - - LAB_N k59_1254114_2 1500301.JQMF01000015_gene4851 4.47e-37 137.0 COG1807@1|root,COG1807@2|Bacteria,1PKMY@1224|Proteobacteria,2VC27@28211|Alphaproteobacteria,4BI00@82115|Rhizobiaceae 28211|Alphaproteobacteria M Dolichyl-phosphate-mannose-protein mannosyltransferase - - - - - - - - - - - - PMT_2 k59_1140715_1 1298867.AUES01000022_gene2847 1.86e-22 102.0 COG0477@1|root,COG2814@2|Bacteria,1MVQQ@1224|Proteobacteria,2TRBF@28211|Alphaproteobacteria,3JXPV@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria EGP Sugar (and other) transporter - - - ko:K08195 - - - - ko00000,ko02000 2.A.1.15 - - MFS_1,MFS_4 k59_1480515_1 702113.PP1Y_AT17372 2.25e-87 263.0 COG1120@1|root,COG1120@2|Bacteria,1QPWJ@1224|Proteobacteria,2U1TK@28211|Alphaproteobacteria,2K1EJ@204457|Sphingomonadales 204457|Sphingomonadales HP ABC transporter - - 3.6.3.34 ko:K02013 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.14 - - ABC_tran k59_1480515_2 1096930.L284_22265 5.33e-46 157.0 COG0609@1|root,COG0609@2|Bacteria,1MV9W@1224|Proteobacteria,2TR9A@28211|Alphaproteobacteria,2K0DB@204457|Sphingomonadales 204457|Sphingomonadales P Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily - - - ko:K02015 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko02000 3.A.1.14 - - FecCD k59_1705588_1 930166.CD58_01860 4.05e-73 231.0 COG2113@1|root,COG2113@2|Bacteria,1MVXS@1224|Proteobacteria,1RQ3U@1236|Gammaproteobacteria 1236|Gammaproteobacteria E COG2113 ABC-type proline glycine betaine transport systems, periplasmic components hisX - - ko:K02002 ko02010,map02010 M00208 - - ko00000,ko00001,ko00002,ko02000 3.A.1.12 - - OpuAC k59_68059_1 1112204.GPOL_c36990 2.2e-13 76.6 COG3173@1|root,COG3173@2|Bacteria,2I8YI@201174|Actinobacteria,4GC24@85026|Gordoniaceae 201174|Actinobacteria S Protein of unknown function (DUF1679) - - - - - - - - - - - - APH,EcKinase k59_859020_1 93220.LV28_12975 1.63e-27 110.0 COG1917@1|root,COG2207@1|root,COG1917@2|Bacteria,COG2207@2|Bacteria,1P1FH@1224|Proteobacteria,2W218@28216|Betaproteobacteria,1KG4N@119060|Burkholderiaceae 28216|Betaproteobacteria K AraC family transcriptional regulator - - - - - - - - - - - - HTH_18 k59_688909_1 498211.CJA_0177 2.41e-127 374.0 COG1282@1|root,COG1282@2|Bacteria,1MUP4@1224|Proteobacteria,1RMR4@1236|Gammaproteobacteria,1FG5E@10|Cellvibrio 1236|Gammaproteobacteria C The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane pntB - 1.6.1.2 ko:K00325 ko00760,ko01100,map00760,map01100 - R00112 RC00001 ko00000,ko00001,ko01000 - - - PNTB k59_124222_1 1168065.DOK_12291 1.61e-31 120.0 COG2828@1|root,COG2828@2|Bacteria,1MXVV@1224|Proteobacteria,1RNE6@1236|Gammaproteobacteria,1J5BN@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S protein conserved in bacteria galD GO:0003674,GO:0003824,GO:0006082,GO:0006725,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016054,GO:0016853,GO:0016860,GO:0016863,GO:0017144,GO:0018918,GO:0018958,GO:0019336,GO:0019396,GO:0019439,GO:0019752,GO:0032787,GO:0042537,GO:0042737,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0071704,GO:0072329,GO:1901360,GO:1901361,GO:1901575,GO:1901615,GO:1901616 5.3.2.8 ko:K16514 ko00362,ko01120,map00362,map01120 - R07839 RC02426 ko00000,ko00001,ko01000 - - - PrpF k59_124222_2 1168065.DOK_12296 1.54e-106 318.0 COG2084@1|root,COG2084@2|Bacteria,1MX8V@1224|Proteobacteria,1RW94@1236|Gammaproteobacteria,1JANY@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria I COG2084 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases - - - - - - - - - - - - DUF1932,NAD_binding_2 k59_350383_1 1121939.L861_17495 4.48e-60 186.0 COG3795@1|root,COG3795@2|Bacteria,1N23Q@1224|Proteobacteria 1224|Proteobacteria S YCII-related domain - - - - - - - - - - - - YCII k59_350383_2 46429.BV95_03551 3.19e-40 138.0 COG0500@1|root,COG0500@2|Bacteria,1QV66@1224|Proteobacteria,2TWBB@28211|Alphaproteobacteria,2KEE1@204457|Sphingomonadales 204457|Sphingomonadales Q Methyltransferase domain - - - - - - - - - - - - Methyltransf_25 k59_1762286_1 158500.BV97_01066 3.3e-69 223.0 COG4638@1|root,COG4638@2|Bacteria,1NSC4@1224|Proteobacteria,2UQBE@28211|Alphaproteobacteria,2K2BM@204457|Sphingomonadales 204457|Sphingomonadales P Ring hydroxylating alpha subunit (catalytic domain) - - - - - - - - - - - - Rieske,Ring_hydroxyl_A k59_350402_1 404589.Anae109_0028 5.89e-18 82.0 COG0656@1|root,COG0656@2|Bacteria,1MX6S@1224|Proteobacteria,4383U@68525|delta/epsilon subdivisions,2X3DT@28221|Deltaproteobacteria,2YVM7@29|Myxococcales 28221|Deltaproteobacteria S Aldo/keto reductase family - - - - - - - - - - - - Aldo_ket_red k59_575793_1 316407.1651560 2.63e-163 464.0 COG0538@1|root,COG0538@2|Bacteria,1MW3J@1224|Proteobacteria,1RNMD@1236|Gammaproteobacteria,3XMJ1@561|Escherichia 1236|Gammaproteobacteria C Isocitrate dehydrogenase icd GO:0003674,GO:0003824,GO:0004448,GO:0004450,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006091,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0022900,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0055114 1.1.1.42 ko:K00031 ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146 M00009,M00010,M00173,M00740 R00267,R00268,R01899 RC00001,RC00084,RC00114,RC00626,RC02801 br01601,ko00000,ko00001,ko00002,ko01000 - - e_coli_core.b1136,iAF1260.b1136,iECDH1ME8569_1439.ECDH1ME8569_1071,iEcDH1_1363.EcDH1_2511,iJN746.PP_4011,iJO1366.b1136,iJR904.b1136,iY75_1357.Y75_RS05930,iYL1228.KPN_01144 Iso_dh k59_180445_1 439235.Dalk_2783 2.37e-41 151.0 COG0477@1|root,COG2814@2|Bacteria,1MV79@1224|Proteobacteria,42R72@68525|delta/epsilon subdivisions,2WMSM@28221|Deltaproteobacteria,2MHXK@213118|Desulfobacterales 28221|Deltaproteobacteria EGP Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 k59_1254143_1 746697.Aeqsu_0648 1.32e-35 130.0 COG0133@1|root,COG0133@2|Bacteria,4NDWP@976|Bacteroidetes,1HXYK@117743|Flavobacteriia 976|Bacteroidetes E The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine trpB - 4.2.1.20,5.3.1.24 ko:K01696,ko:K01817 ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230 M00023 R00674,R02340,R02722,R03509 RC00209,RC00210,RC00700,RC00701,RC00945,RC02868 ko00000,ko00001,ko00002,ko01000 - - - PALP k59_1254143_2 1178825.ALIH01000020_gene2725 1.24e-48 161.0 COG0135@1|root,COG0135@2|Bacteria,4NNQ1@976|Bacteroidetes,1I1CD@117743|Flavobacteriia 976|Bacteroidetes E Belongs to the TrpF family trpF - 5.3.1.24 ko:K01817 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R03509 RC00945 ko00000,ko00001,ko00002,ko01000 - - - PRAI k59_970922_1 1122137.AQXF01000001_gene3267 3.65e-107 337.0 COG1674@1|root,COG1674@2|Bacteria,1MVPI@1224|Proteobacteria,2TR48@28211|Alphaproteobacteria 28211|Alphaproteobacteria D COG1674 DNA segregation ATPase FtsK SpoIIIE and related proteins ftsK - - ko:K03466 - - - - ko00000,ko03036 3.A.12 - - FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma k59_1536472_1 118161.KB235922_gene5317 2.96e-27 116.0 COG0643@1|root,COG0745@1|root,COG2198@1|root,COG0643@2|Bacteria,COG0745@2|Bacteria,COG2198@2|Bacteria,1G0VR@1117|Cyanobacteria,3VJ4D@52604|Pleurocapsales 1117|Cyanobacteria T Response regulator receiver domain - - - ko:K11526 ko02020,map02020 M00508 - - ko00000,ko00001,ko00002,ko01001,ko02022,ko02035 - - - CheW,H-kinase_dim,HATPase_c,Hpt,Response_reg k59_632250_1 1224746.B932_3135 3.23e-06 53.5 COG2197@1|root,COG2197@2|Bacteria,1MVNV@1224|Proteobacteria,2TTK7@28211|Alphaproteobacteria 28211|Alphaproteobacteria T Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain - - - - - - - - - - - - GerE,Response_reg k59_632250_2 1082933.MEA186_02634 3.26e-19 91.3 COG3916@1|root,COG3916@2|Bacteria,1MXFA@1224|Proteobacteria,2U30F@28211|Alphaproteobacteria 28211|Alphaproteobacteria QT Acyl-homoserine-lactone synthase mrlI - 2.3.1.228,2.3.1.229 ko:K18096 ko02024,map02024 - - - ko00000,ko00001,ko01000 - - - Autoind_synth k59_632250_3 1122137.AQXF01000007_gene3520 4.58e-37 134.0 COG1485@1|root,COG1485@2|Bacteria,1MUUW@1224|Proteobacteria,2TRG1@28211|Alphaproteobacteria 28211|Alphaproteobacteria E ATPase, AFG1 family zapE GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0006091,GO:0006119,GO:0006123,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006996,GO:0007005,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009060,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016020,GO:0016043,GO:0016310,GO:0017144,GO:0019538,GO:0019637,GO:0019646,GO:0019693,GO:0022900,GO:0022904,GO:0030163,GO:0031090,GO:0031966,GO:0031967,GO:0031975,GO:0034641,GO:0035694,GO:0042773,GO:0042775,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044281,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0045333,GO:0046034,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0071840,GO:0072521,GO:1901135,GO:1901360,GO:1901564,GO:1901565,GO:1901575 - ko:K06916 - - - - ko00000,ko03036 - - - AFG1_ATPase k59_462997_1 997352.HMPREF9419_0616 2.05e-30 124.0 COG1502@1|root,COG1502@2|Bacteria,4NG0Z@976|Bacteroidetes,2FMNG@200643|Bacteroidia 976|Bacteroidetes M Belongs to the phospholipase D family. Cardiolipin synthase subfamily cls - - ko:K06131 ko00564,ko01100,map00564,map01100 - R07390 RC00017 ko00000,ko00001,ko01000 - - - PLDc_2 k59_688940_1 1341181.FLJC2902T_13090 1.71e-64 225.0 2BWG8@1|root,2Z8GJ@2|Bacteria,4NEM1@976|Bacteroidetes,1I0BJ@117743|Flavobacteriia,2NV15@237|Flavobacterium 976|Bacteroidetes - - - - - - - - - - - - - - - k59_519170_1 243231.GSU1927 3.12e-42 157.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,42M0W@68525|delta/epsilon subdivisions,2WIK8@28221|Deltaproteobacteria,43UE7@69541|Desulfuromonadales 28221|Deltaproteobacteria T Response regulator receiver modulated diguanylate cyclase phosphodiesterase with PAS PAC sensor(S) - - - - - - - - - - - - EAL,GGDEF,PAS_3,Response_reg k59_11389_1 266779.Meso_2043 6.87e-75 238.0 COG0624@1|root,COG0624@2|Bacteria,1MVUX@1224|Proteobacteria,2TR5X@28211|Alphaproteobacteria,43IZC@69277|Phyllobacteriaceae 28211|Alphaproteobacteria E the allantoate amidohydrolase from Escherichia coli forms a dimer and binds zinc ions for catalytic activity and catalyzes the conversion of allantoate to (S)-ureidoglycolate and ammonia amaB GO:0003674,GO:0005488,GO:0005515,GO:0042802 3.5.1.6,3.5.1.87 ko:K06016 ko00240,ko01100,map00240,map01100 M00046 R00905,R04666 RC00096 ko00000,ko00001,ko00002,ko01000 - - - M20_dimer,Peptidase_M20,Peptidase_M28 k59_1254156_1 981336.F944_01187 1.01e-40 147.0 COG0548@1|root,COG1246@1|root,COG0548@2|Bacteria,COG1246@2|Bacteria,1MUUP@1224|Proteobacteria,1RMV5@1236|Gammaproteobacteria,3NIZC@468|Moraxellaceae 1236|Gammaproteobacteria E Belongs to the acetyltransferase family. ArgA subfamily argA GO:0003674,GO:0003824,GO:0004042,GO:0004358,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.3.1.1 ko:K14682 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028 R00259 RC00004,RC00064 ko00000,ko00001,ko00002,ko01000 - - iECP_1309.ECP_2830,iLF82_1304.LF82_0116,iNRG857_1313.NRG857_13920,iYL1228.KPN_03226 AA_kinase,Acetyltransf_1 k59_1141748_1 1089550.ATTH01000001_gene2480 3.51e-13 69.3 COG0308@1|root,COG0308@2|Bacteria,4NFNJ@976|Bacteroidetes,1FK1K@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes E Peptidase family M1 domain - - - - - - - - - - - - Peptidase_M1 k59_1141748_2 450380.JPSY01000001_gene404 0.000748 44.3 COG2314@1|root,COG2314@2|Bacteria,2ICDQ@201174|Actinobacteria,4FPZR@85023|Microbacteriaceae 201174|Actinobacteria S TM2 domain - - - - - - - - - - - - TM2 k59_1593865_1 1122604.JONR01000001_gene1679 1.11e-34 144.0 COG2373@1|root,COG2373@2|Bacteria,1MV7J@1224|Proteobacteria,1RNRY@1236|Gammaproteobacteria,1X4ST@135614|Xanthomonadales 135614|Xanthomonadales S Large extracellular alpha-helical protein - - - ko:K06894 - - - - ko00000 - - - A2M,A2M_N,A2M_N_2,MG1 k59_633357_1 697282.Mettu_4092 4.27e-25 97.8 COG5606@1|root,COG5606@2|Bacteria,1N7ZQ@1224|Proteobacteria,1SFHF@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Helix-turn-helix domain - - - - - - - - - - - - HTH_37 k59_633357_2 228410.NE2102 7.01e-18 77.0 COG3514@1|root,COG3514@2|Bacteria,1NAV1@1224|Proteobacteria,2W4YE@28216|Betaproteobacteria,374JI@32003|Nitrosomonadales 28216|Betaproteobacteria S BrnA antitoxin of type II toxin-antitoxin system - - - - - - - - - - - - BrnA_antitoxin k59_1311839_2 1231057.AMGD01000091_gene1657 2.51e-24 104.0 COG0281@1|root,COG0281@2|Bacteria,1TPJ3@1239|Firmicutes,4H9WR@91061|Bacilli,26E15@186818|Planococcaceae 91061|Bacilli C Malic enzyme, NAD binding domain ytsJ - 1.1.1.38 ko:K00027 ko00620,ko01200,ko02020,map00620,map01200,map02020 - R00214 RC00105 ko00000,ko00001,ko01000 - - - Malic_M,malic k59_1368461_1 521460.Athe_1161 1.83e-18 88.6 COG0226@1|root,COG0226@2|Bacteria,1TQ5X@1239|Firmicutes,248QU@186801|Clostridia,42EPR@68295|Thermoanaerobacterales 186801|Clostridia P PFAM extracellular solute-binding protein family 1 pstS - - ko:K02040 ko02010,ko02020,ko05152,map02010,map02020,map05152 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - PBP_like_2 k59_12395_1 595460.RRSWK_06982 7.16e-05 50.4 COG1361@1|root,COG4932@1|root,COG1361@2|Bacteria,COG4932@2|Bacteria,2IYS8@203682|Planctomycetes 203682|Planctomycetes M Domain of unknown function DUF11 - - - - - - - - - - - - DUF11,SdrD_B k59_295106_1 1125863.JAFN01000001_gene1780 1.63e-90 268.0 COG1150@1|root,COG1150@2|Bacteria,1N2IK@1224|Proteobacteria,42RP6@68525|delta/epsilon subdivisions,2WQ1G@28221|Deltaproteobacteria 28221|Deltaproteobacteria C 4Fe-4S dicluster domain hdrC - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 ko:K03390 ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200 M00356,M00357,M00563,M00567 R04540,R11928,R11931,R11943,R11944 RC00011 ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_3424 Fer4_17,Fer4_9 k59_689790_1 1123399.AQVE01000002_gene2470 2.59e-77 236.0 COG2003@1|root,COG2003@2|Bacteria,1MXZ5@1224|Proteobacteria,1RP86@1236|Gammaproteobacteria,460D0@72273|Thiotrichales 72273|Thiotrichales E Belongs to the UPF0758 family - - - ko:K03630 - - - - ko00000 - - - RadC k59_1141781_1 1502770.JQMG01000001_gene2416 6.33e-55 195.0 COG2304@1|root,COG2931@1|root,COG3898@1|root,COG5295@1|root,COG2304@2|Bacteria,COG2931@2|Bacteria,COG3898@2|Bacteria,COG5295@2|Bacteria,1MU7T@1224|Proteobacteria,2VKA9@28216|Betaproteobacteria,2KNPI@206350|Nitrosomonadales 206350|Nitrosomonadales Q von Willebrand factor (vWF) type A domain - - - - - - - - - - - - HemolysinCabind,VWA_2 k59_803509_1 1144305.PMI02_00836 1.38e-79 240.0 COG3194@1|root,COG3194@2|Bacteria,1NAR2@1224|Proteobacteria 1224|Proteobacteria F Ureidoglycolate lyase - - 4.3.2.3 ko:K01483 ko00230,ko01100,map00230,map01100 - R00776 RC00153,RC00379 ko00000,ko00001,ko01000 - - - Ureidogly_lyase k59_1141782_1 194867.ALBQ01000008_gene2109 9.59e-51 175.0 COG1596@1|root,COG1596@2|Bacteria,1N7GP@1224|Proteobacteria,2TS5Q@28211|Alphaproteobacteria,2K2AX@204457|Sphingomonadales 204457|Sphingomonadales M polysaccharide - - - ko:K01991 ko02026,map02026 - - - ko00000,ko00001,ko02000 1.B.18 - - Poly_export,SLBB k59_1593905_1 631362.Thi970DRAFT_02773 1.6e-44 160.0 COG0845@1|root,COG0845@2|Bacteria,1MUFW@1224|Proteobacteria,1RQJ9@1236|Gammaproteobacteria,1WWA8@135613|Chromatiales 135613|Chromatiales M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - ko:K03585 ko01501,ko01503,map01501,map01503 M00646,M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000,ko03036 2.A.6.2,8.A.1.6 - - HlyD_D23 k59_1311878_2 1458357.BG58_27475 1.75e-45 151.0 COG2764@1|root,COG2764@2|Bacteria,1RF5T@1224|Proteobacteria,2VS3X@28216|Betaproteobacteria,1KH9H@119060|Burkholderiaceae 28216|Betaproteobacteria S Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - - - - - - - - - - Glyoxalase k59_860361_2 187303.BN69_2713 5.8e-26 99.4 2DNP1@1|root,32YDC@2|Bacteria,1N7FK@1224|Proteobacteria,2UGCU@28211|Alphaproteobacteria,370P4@31993|Methylocystaceae 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_860361_3 1234595.C725_1201 6.03e-19 85.9 COG3182@1|root,COG3182@2|Bacteria,1MVET@1224|Proteobacteria,2TVHW@28211|Alphaproteobacteria 28211|Alphaproteobacteria IQ iron-regulated membrane protein - - - - - - - - - - - - PepSY_TM k59_1650573_1 246197.MXAN_2232 3.39e-90 276.0 COG1741@1|root,COG1741@2|Bacteria,1MWIP@1224|Proteobacteria,42UHA@68525|delta/epsilon subdivisions,2WQA0@28221|Deltaproteobacteria,2YUHZ@29|Myxococcales 28221|Deltaproteobacteria S Belongs to the pirin family - - - ko:K06911 - - - - ko00000 - - - Pirin,Pirin_C k59_463973_1 377629.TERTU_0611 3.51e-53 176.0 COG0320@1|root,COG0320@2|Bacteria,1MVRD@1224|Proteobacteria,1RMAT@1236|Gammaproteobacteria,2PN18@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria H Elongator protein 3, MiaB family, Radical SAM lipA GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009106,GO:0009107,GO:0009108,GO:0009249,GO:0009987,GO:0010467,GO:0016053,GO:0016740,GO:0016782,GO:0016783,GO:0016992,GO:0018065,GO:0018130,GO:0018193,GO:0018205,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0051604,GO:0070283,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901576 2.8.1.8 ko:K03644 ko00785,ko01100,map00785,map01100 - R07767,R07768 RC01978 ko00000,ko00001,ko01000 - - iAPECO1_1312.APECO1_1427,iB21_1397.B21_00586,iBWG_1329.BWG_0499,iE2348C_1286.E2348C_0528,iEC55989_1330.EC55989_0620,iECABU_c1320.ECABU_c06820,iECBD_1354.ECBD_3023,iECB_1328.ECB_00597,iECDH10B_1368.ECDH10B_0589,iECDH1ME8569_1439.ECDH1ME8569_0597,iECD_1391.ECD_00597,iECED1_1282.ECED1_0624,iECH74115_1262.ECH74115_0716,iECIAI1_1343.ECIAI1_0611,iECIAI39_1322.ECIAI39_0603,iECNA114_1301.ECNA114_0567,iECO103_1326.ECO103_0635,iECO111_1330.ECO111_0658,iECO26_1355.ECO26_0702,iECOK1_1307.ECOK1_0638,iECP_1309.ECP_0658,iECS88_1305.ECS88_0669,iECSE_1348.ECSE_0695,iECSF_1327.ECSF_0567,iECSP_1301.ECSP_0681,iECUMN_1333.ECUMN_0720,iECW_1372.ECW_m0682,iECs_1301.ECs0666,iEKO11_1354.EKO11_3238,iETEC_1333.ETEC_0656,iEcDH1_1363.EcDH1_2998,iEcE24377_1341.EcE24377A_0652,iEcHS_1320.EcHS_A0679,iEcSMS35_1347.EcSMS35_0648,iEcolC_1368.EcolC_3017,iG2583_1286.G2583_0791,iJO1366.b0628,iLF82_1304.LF82_1199,iNRG857_1313.NRG857_02855,iSBO_1134.SBO_0492,iSDY_1059.SDY_0550,iSF_1195.SF0653,iSFxv_1172.SFxv_0720,iSSON_1240.SSON_0582,iS_1188.S0675,iSbBS512_1146.SbBS512_E0542,iUMN146_1321.UM146_14375,iUMNK88_1353.UMNK88_663,iUTI89_1310.UTI89_C0631,iWFL_1372.ECW_m0682,iY75_1357.Y75_RS03275,ic_1306.c0718 LIAS_N,Radical_SAM k59_1198399_1 926569.ANT_19080 1.38e-19 87.8 COG0593@1|root,COG0593@2|Bacteria,2G5W8@200795|Chloroflexi 200795|Chloroflexi L it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids dnaA GO:0003674,GO:0003676,GO:0003677,GO:0003688,GO:0003690,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0034641,GO:0034645,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901576,GO:1990837 - ko:K02313 ko02020,ko04112,map02020,map04112 - - - ko00000,ko00001,ko03032,ko03036 - - - Bac_DnaA,Bac_DnaA_C,DnaA_N k59_1141798_1 479434.Sthe_1802 4.59e-56 185.0 COG0113@1|root,COG0113@2|Bacteria,2G5QT@200795|Chloroflexi,27XTX@189775|Thermomicrobia 189775|Thermomicrobia H Delta-aminolevulinic acid dehydratase - - 4.2.1.24 ko:K01698 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R00036 RC00918,RC01781 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ALAD k59_1141798_2 562970.Btus_0653 3.2e-09 62.8 COG0007@1|root,COG1587@1|root,COG0007@2|Bacteria,COG1587@2|Bacteria,1TQNH@1239|Firmicutes,4HBB7@91061|Bacilli,278F6@186823|Alicyclobacillaceae 91061|Bacilli H Uroporphyrinogen-III synthase HemD - - 2.1.1.107,4.2.1.75 ko:K02303,ko:K13542 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R03165,R03194 RC00003,RC00871,RC01861 ko00000,ko00001,ko00002,ko01000 - - - HEM4,TP_methylase k59_237745_1 106582.XP_004558087.1 7e-18 82.0 COG0176@1|root,KOG2772@2759|Eukaryota,38BFF@33154|Opisthokonta,3BD0E@33208|Metazoa,3CRJ2@33213|Bilateria,489B2@7711|Chordata,491AD@7742|Vertebrata,49T7A@7898|Actinopterygii 33208|Metazoa G Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway TALDO1 GO:0003674,GO:0003824,GO:0004801,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0005997,GO:0005999,GO:0006002,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0007166,GO:0008150,GO:0008152,GO:0009052,GO:0009058,GO:0009117,GO:0009987,GO:0010033,GO:0016051,GO:0016740,GO:0016744,GO:0019221,GO:0019321,GO:0019322,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0023052,GO:0030246,GO:0031974,GO:0031981,GO:0034097,GO:0034641,GO:0035722,GO:0036094,GO:0042221,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0044237,GO:0044238,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044428,GO:0044444,GO:0044446,GO:0044464,GO:0046364,GO:0046483,GO:0046496,GO:0048029,GO:0050789,GO:0050794,GO:0050896,GO:0051156,GO:0051186,GO:0051716,GO:0055086,GO:0065007,GO:0070013,GO:0070671,GO:0070887,GO:0071310,GO:0071345,GO:0071349,GO:0071704,GO:0072524,GO:1901135,GO:1901360,GO:1901564,GO:1901576 2.2.1.2 ko:K00616 ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007 R01827 RC00439,RC00604 ko00000,ko00001,ko00002,ko01000 - - - TAL_FSA k59_237745_2 384765.SIAM614_04130 1.01e-65 208.0 COG2126@1|root,COG2126@2|Bacteria,1MXCS@1224|Proteobacteria,2TWZ9@28211|Alphaproteobacteria 28211|Alphaproteobacteria J Ion channel - - - ko:K10716 - - - - ko00000,ko02000 1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6 - - Ion_trans_2 k59_1706502_1 1144305.PMI02_03639 3.12e-113 336.0 COG0161@1|root,COG0161@2|Bacteria,1MU2N@1224|Proteobacteria,2TQND@28211|Alphaproteobacteria,2K04K@204457|Sphingomonadales 204457|Sphingomonadales E Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family bioA - 2.6.1.62 ko:K00833 ko00780,ko01100,map00780,map01100 M00123,M00573,M00577 R03231 RC00006,RC00887 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 k59_1029973_1 1122137.AQXF01000004_gene1625 5.67e-132 390.0 COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2TR2W@28211|Alphaproteobacteria 28211|Alphaproteobacteria IQ COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II acsf - - ko:K00666 - - - - ko00000,ko01000,ko01004 - - - AMP-binding,AMP-binding_C k59_463981_1 1280949.HAD_06225 9.87e-54 181.0 COG0277@1|root,COG0277@2|Bacteria,1NB6A@1224|Proteobacteria,2U3ZG@28211|Alphaproteobacteria,43ZF5@69657|Hyphomonadaceae 28211|Alphaproteobacteria C COG0277 FAD FMN-containing dehydrogenases xyoA - 1.1.3.41 ko:K00594 ko00040,ko00051,ko01100,map00040,map00051,map01100 - R07152,R11620 RC00108,RC00133 ko00000,ko00001,ko01000 - - - ALO,FAD_binding_4 k59_463981_2 1280949.HAD_06220 4.1e-60 198.0 COG3616@1|root,COG3616@2|Bacteria,1MXV3@1224|Proteobacteria,2TTPK@28211|Alphaproteobacteria,43ZE0@69657|Hyphomonadaceae 28211|Alphaproteobacteria E amino acid aldolase or racemase - - - - - - - - - - - - Ala_racemase_N k59_915821_1 1137281.D778_02537 9.22e-64 213.0 COG0683@1|root,COG1388@1|root,COG0683@2|Bacteria,COG1388@2|Bacteria,4NG96@976|Bacteroidetes,1HY84@117743|Flavobacteriia 976|Bacteroidetes EM LysM domain lysM - - - - - - - - - - - ANF_receptor,LysM,Peripla_BP_6 k59_1141815_1 1229909.NSED_00915 1.13e-70 218.0 COG0120@1|root,arCOG01122@2157|Archaea,41SJE@651137|Thaumarchaeota 651137|Thaumarchaeota G Ribose 5-phosphate isomerase - - 5.3.1.6 ko:K01807 ko00030,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167,M00580 R01056 RC00434 ko00000,ko00001,ko00002,ko01000 - - - Rib_5-P_isom_A k59_1593917_1 1122137.AQXF01000004_gene1853 2.73e-30 119.0 2DNWA@1|root,32ZHF@2|Bacteria 2|Bacteria S Domain of unknown function (DUF4167) - - - - - - - - - - - - DUF4167 k59_1593917_2 588932.JHOF01000017_gene2469 6.66e-33 125.0 COG2890@1|root,COG2890@2|Bacteria,1MXCQ@1224|Proteobacteria,2TZFK@28211|Alphaproteobacteria,2KG3D@204458|Caulobacterales 204458|Caulobacterales J Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif prmC - 2.1.1.297 ko:K02493 - - R10806 RC00003,RC03279 ko00000,ko01000,ko03012 - - - Methyltransf_31 k59_463984_1 443144.GM21_0875 4.73e-21 98.2 COG3303@1|root,COG3303@2|Bacteria,1R8WP@1224|Proteobacteria,42VEM@68525|delta/epsilon subdivisions,2WRGV@28221|Deltaproteobacteria 28221|Deltaproteobacteria C Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process - - - - - - - - - - - - - k59_1029991_1 979556.MTES_0138 2.32e-11 67.8 COG3663@1|root,COG3663@2|Bacteria,2GNS5@201174|Actinobacteria,4FPCR@85023|Microbacteriaceae 201174|Actinobacteria L Uracil DNA glycosylase superfamily mug - 3.2.2.28 ko:K03649 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - UDG k59_295157_1 1170562.Cal6303_0331 5.52e-21 89.7 COG5485@1|root,COG5485@2|Bacteria,1GCZD@1117|Cyanobacteria,1HT70@1161|Nostocales 1117|Cyanobacteria S SnoaL-like polyketide cyclase - - - - - - - - - - - - SnoaL k59_1029992_1 391625.PPSIR1_03103 3.77e-42 161.0 COG0026@1|root,COG2833@1|root,COG0026@2|Bacteria,COG2833@2|Bacteria,1MW0V@1224|Proteobacteria,42KZ6@68525|delta/epsilon subdivisions,2WVSN@28221|Deltaproteobacteria,2Z1YP@29|Myxococcales 28221|Deltaproteobacteria F Protein of unknown function (DUF455) - - - - - - - - - - - - DUF455 k59_1763347_1 316407.1742730 1.01e-47 162.0 COG0477@1|root,COG2814@2|Bacteria,1MU9G@1224|Proteobacteria,1RM9G@1236|Gammaproteobacteria,3XM7H@561|Escherichia 1236|Gammaproteobacteria EGP transmembrane transport ydhP GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K18567,ko:K19577 - - - - ko00000,ko02000 2.A.1.2.25,2.A.1.2.65 - - MFS_1 k59_1763347_2 1440052.EAKF1_ch4392 9.19e-12 58.9 2AUW7@1|root,31KJN@2|Bacteria,1QIEX@1224|Proteobacteria,1TG9A@1236|Gammaproteobacteria,3XQ59@561|Escherichia 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_1029994_1 985867.AEWF01000003_gene785 1.5e-68 217.0 COG3555@1|root,COG3555@2|Bacteria,1MW3M@1224|Proteobacteria,2TRVQ@28211|Alphaproteobacteria,47FVE@766|Rickettsiales 766|Rickettsiales O Aspartyl/Asparaginyl beta-hydroxylase - - - ko:K12979 - - - - ko00000,ko01000,ko01005 - - - Asp_Arg_Hydrox k59_1763348_1 1356852.N008_14430 2.51e-67 218.0 COG1288@1|root,COG1288@2|Bacteria,4NEUI@976|Bacteroidetes,47MN0@768503|Cytophagia 976|Bacteroidetes S C4-dicarboxylate anaerobic carrier - - - - - - - - - - - - DcuC k59_469333_1 871585.BDGL_000161 1.1e-74 236.0 COG2805@1|root,COG2805@2|Bacteria,1MU3J@1224|Proteobacteria,1RN8G@1236|Gammaproteobacteria,3NJ7T@468|Moraxellaceae 1236|Gammaproteobacteria NU twitching motility protein pilT GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - ko:K02669 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE k59_525302_1 702113.PP1Y_AT9994 8.98e-53 185.0 COG0243@1|root,COG1251@1|root,COG0243@2|Bacteria,COG1251@2|Bacteria,1NS3T@1224|Proteobacteria,2TQYD@28211|Alphaproteobacteria,2K1FR@204457|Sphingomonadales 204457|Sphingomonadales C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - - ko:K00372 ko00910,ko01120,map00910,map01120 M00531 R00798,R01106 RC02812 ko00000,ko00001,ko00002,ko01000 - - - Fer2_BFD,Molybdop_Fe4S4,Molybdopterin,Molydop_binding k59_525302_2 1144305.PMI02_01756 1.3e-21 90.5 COG0007@1|root,COG0007@2|Bacteria,1MUI0@1224|Proteobacteria,2TRJC@28211|Alphaproteobacteria,2K111@204457|Sphingomonadales 204457|Sphingomonadales H Belongs to the precorrin methyltransferase family - - 2.1.1.107 ko:K02303 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R03194 RC00003,RC00871 ko00000,ko00001,ko00002,ko01000 - - - TP_methylase k59_525307_1 2850.Phatr40593 5.93e-11 65.9 2CY1Q@1|root,2S1CE@2759|Eukaryota 2759|Eukaryota S Sulfite exporter TauE/SafE - - - - - - - - - - - - TauE k59_525307_2 1122137.AQXF01000004_gene1730 7.35e-136 399.0 COG3104@1|root,COG3104@2|Bacteria,1P6K2@1224|Proteobacteria 1224|Proteobacteria E PFAM major facilitator superfamily MFS_1 - - - - - - - - - - - - MFS_1 k59_300715_1 1453501.JELR01000005_gene1704 1.97e-43 152.0 COG0340@1|root,COG1654@1|root,COG0340@2|Bacteria,COG1654@2|Bacteria,1MWCC@1224|Proteobacteria,1RNGC@1236|Gammaproteobacteria,465FU@72275|Alteromonadaceae 1236|Gammaproteobacteria K Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon birA GO:0000166,GO:0000976,GO:0000984,GO:0001017,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003824,GO:0004077,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0006082,GO:0006464,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009305,GO:0009374,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0017053,GO:0017076,GO:0017144,GO:0018130,GO:0018271,GO:0019538,GO:0019752,GO:0019842,GO:0030554,GO:0031406,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0032991,GO:0033218,GO:0033293,GO:0034641,GO:0035639,GO:0036094,GO:0036211,GO:0042364,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043565,GO:0043603,GO:0043604,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0046983,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901681,GO:1990837 6.3.4.15 ko:K03524 ko00780,ko01100,map00780,map01100 - R01074,R05145 RC00043,RC00070,RC00096,RC02896 ko00000,ko00001,ko01000,ko03000 - - - BPL_C,BPL_LplA_LipB,HTH_11 k59_696001_1 1229909.NSED_00720 3.11e-68 216.0 COG0079@1|root,arCOG04273@2157|Archaea,41SGB@651137|Thaumarchaeota 651137|Thaumarchaeota E PFAM Aminotransferase class I and II - - 2.6.1.9 ko:K00817 ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230 M00026 R00694,R00734,R03243 RC00006,RC00888 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 k59_696001_2 1229909.NSED_00715 1.92e-72 230.0 COG0141@1|root,arCOG04352@2157|Archaea,41S6J@651137|Thaumarchaeota 651137|Thaumarchaeota E Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine hisD - 1.1.1.23 ko:K00013 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R01158,R01163,R03012 RC00099,RC00242,RC00463 ko00000,ko00001,ko00002,ko01000 - - - Histidinol_dh k59_357805_1 1227454.C446_14209 5.3e-11 64.3 COG1628@1|root,arCOG00928@2157|Archaea,2XXBV@28890|Euryarchaeota,23VNR@183963|Halobacteria 183963|Halobacteria L Belongs to the UPF0215 family - - - ko:K09120 - - - - ko00000 - - - DUF99 k59_357805_2 1229909.NSED_03260 3.74e-109 318.0 COG1028@1|root,arCOG01259@2157|Archaea,41SXY@651137|Thaumarchaeota 651137|Thaumarchaeota I Short-chain dehydrogenase reductase SDR - - 1.1.1.100 ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 k59_866508_1 1111728.ATYS01000004_gene1593 2.12e-26 111.0 COG1984@1|root,COG1984@2|Bacteria,1MU9H@1224|Proteobacteria,1RR39@1236|Gammaproteobacteria 1236|Gammaproteobacteria E Allophanate hydrolase subunit 2 Z012_10780 - 3.5.1.54,6.3.4.6 ko:K01457,ko:K01941 ko00220,ko00791,ko01100,ko01120,map00220,map00791,map01100,map01120 - R00005,R00774 RC00378,RC02756 ko00000,ko00001,ko01000 - - - CT_A_B k59_1600026_2 1380394.JADL01000003_gene4842 1.04e-72 231.0 COG0183@1|root,COG0183@2|Bacteria,1MXYM@1224|Proteobacteria,2TUBT@28211|Alphaproteobacteria,2JV5N@204441|Rhodospirillales 204441|Rhodospirillales I Thiolase, C-terminal domain - - - - - - - - - - - - Thiolase_C,Thiolase_N k59_357809_1 400668.Mmwyl1_0216 1.55e-49 173.0 COG0754@1|root,COG3942@1|root,COG0754@2|Bacteria,COG3942@2|Bacteria,1MW6V@1224|Proteobacteria,1RQAP@1236|Gammaproteobacteria,1XHKB@135619|Oceanospirillales 135619|Oceanospirillales E Glutathionylspermidine synthase - - 3.5.1.78,6.3.1.8 ko:K01460 ko00480,ko01100,map00480,map01100 - R01917,R01918 RC00090,RC00096 ko00000,ko00001,ko01000 - - - CHAP,GSP_synth k59_357809_2 243365.CV_2781 0.000915 40.4 COG3791@1|root,COG3791@2|Bacteria,1N023@1224|Proteobacteria,2WFT4@28216|Betaproteobacteria 28216|Betaproteobacteria S Glutathione-dependent formaldehyde-activating enzyme - - - - - - - - - - - - GFA k59_1487831_2 1232410.KI421413_gene573 5.28e-07 50.4 COG4276@1|root,COG4276@2|Bacteria,1N6EC@1224|Proteobacteria,42U3N@68525|delta/epsilon subdivisions,2WQTN@28221|Deltaproteobacteria,43VBV@69541|Desulfuromonadales 28221|Deltaproteobacteria S Pfam Polyketide cyclase dehydrase and lipid transport - - - - - - - - - - - - Polyketide_cyc k59_1769470_1 436308.Nmar_0018 1.12e-33 119.0 arCOG08804@1|root,arCOG08804@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_1769470_4 1229909.NSED_02945 6.42e-42 142.0 COG0071@1|root,arCOG01832@2157|Archaea 2157|Archaea O Belongs to the small heat shock protein (HSP20) family hsp20 - - ko:K13993 ko04141,map04141 - - - ko00000,ko00001,ko03110 - - - HSP20 k59_1769470_5 1229909.NSED_02950 2.12e-90 272.0 COG1938@1|root,arCOG00347@2157|Archaea 2157|Archaea S COG1938 Archaeal enzymes of ATP-grasp superfamily - - - ko:K06869 - - - - ko00000 - - - PAC2 k59_696013_1 1123372.AUIT01000001_gene823 1.17e-32 125.0 COG2199@1|root,COG3706@2|Bacteria,2GI8M@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria T diguanylate cyclase - - - - - - - - - - - - GGDEF k59_1204631_1 88036.EFJ19249 1.94e-52 187.0 COG3693@1|root,2QSCW@2759|Eukaryota,37J3J@33090|Viridiplantae,3GCMG@35493|Streptophyta 35493|Streptophyta G glycosyl hydrolase family 10 protein - - 3.2.1.8 ko:K01181 - - - - ko00000,ko01000 - - - CBM_4_9,Glyco_hydro_10 k59_243964_1 35754.JNYJ01000014_gene4769 3.55e-173 509.0 COG0243@1|root,COG0243@2|Bacteria,2GNYQ@201174|Actinobacteria,4DI2D@85008|Micromonosporales 201174|Actinobacteria C Molybdopterin oxidoreductase Fe4S4 domain - - - - - - - - - - - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding k59_1430270_1 1122137.AQXF01000001_gene2579 1.17e-13 76.3 COG2931@1|root,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,2U7AB@28211|Alphaproteobacteria 28211|Alphaproteobacteria MQ Haemolysin-type calcium-binding repeat (2 copies) - - - - - - - - - - - - HemolysinCabind k59_1091535_1 926560.KE387023_gene2254 2.07e-43 156.0 COG0372@1|root,COG0372@2|Bacteria,1WMD6@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus C Helix-turn-helix domain - - 2.3.3.1 ko:K01647 ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00740 R00351 RC00004,RC00067 br01601,ko00000,ko00001,ko00002,ko01000 - - - Citrate_synt,HTH_17 k59_866544_1 1123290.AUDQ01000014_gene1132 8.32e-16 75.9 COG0274@1|root,COG0274@2|Bacteria,1TPAJ@1239|Firmicutes,4HAAJ@91061|Bacilli,26DK8@186818|Planococcaceae 91061|Bacilli F Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate deoC - 4.1.2.4 ko:K01619 ko00030,map00030 - R01066 RC00436,RC00437 ko00000,ko00001,ko01000 - - - DeoC k59_866544_2 1203605.HMPREF1531_00752 1.83e-20 84.7 COG4576@1|root,COG4576@2|Bacteria,2GT97@201174|Actinobacteria,4DVTC@85009|Propionibacteriales 201174|Actinobacteria CQ Ethanolamine utilisation protein EutN/carboxysome - - - ko:K04028 - - - - ko00000 - - - EutN_CcmL k59_188193_1 395495.Lcho_3178 9.36e-54 181.0 COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2VHK8@28216|Betaproteobacteria,1KJ80@119065|unclassified Burkholderiales 28216|Betaproteobacteria S Tripartite tricarboxylate transporter family receptor - - - - - - - - - - - - TctC k59_1769502_1 316407.85674315 1.13e-234 649.0 COG0477@1|root,COG2814@2|Bacteria,1MWWU@1224|Proteobacteria,1RN2I@1236|Gammaproteobacteria,3XP9H@561|Escherichia 1236|Gammaproteobacteria P Involved in the efflux of sugars. The physiological role may be the detoxification of non-metabolizable sugar analogs. Can transport IPTG, lactose and glucose. Has broad substrate specificity, with preferences for glucosides or galactosides with alkyl or aryl substituents setA GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006950,GO:0007059,GO:0008150,GO:0008643,GO:0009987,GO:0015766,GO:0015767,GO:0015772,GO:0016020,GO:0016021,GO:0031224,GO:0033554,GO:0036447,GO:0036448,GO:0044425,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0051716,GO:0071702,GO:0071944 - ko:K03291 - - - - ko00000,ko02000 2.A.1.20 - iEC042_1314.EC042_2403,iECDH1ME8569_1439.ECDH1ME8569_0068 MFS_1 k59_866548_1 702113.PP1Y_AT30034 8.48e-45 157.0 COG0062@1|root,COG0063@1|root,COG0062@2|Bacteria,COG0063@2|Bacteria,1MU1Q@1224|Proteobacteria,2TT58@28211|Alphaproteobacteria,2K1P3@204457|Sphingomonadales 204457|Sphingomonadales G Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration nnrD - - - - - - - - - - - Carb_kinase,YjeF_N k59_866548_2 702113.PP1Y_AT30022 1.57e-54 182.0 COG2265@1|root,COG2265@2|Bacteria,1MV3A@1224|Proteobacteria,2TR40@28211|Alphaproteobacteria,2K0YT@204457|Sphingomonadales 204457|Sphingomonadales J Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family - - 2.1.1.190 ko:K03215 - - - - ko00000,ko01000,ko03009 - - - tRNA_U5-meth_tr k59_1374635_1 1168065.DOK_02421 1.07e-79 263.0 COG1014@1|root,COG4231@1|root,COG1014@2|Bacteria,COG4231@2|Bacteria,1MUKS@1224|Proteobacteria,1RSEQ@1236|Gammaproteobacteria 1236|Gammaproteobacteria C indolepyruvate ferredoxin oxidoreductase iorA - 1.2.7.8 ko:K04090 - - - - br01601,ko00000,ko01000 - - - POR,TPP_enzyme_C k59_922189_1 627192.SLG_01040 7.66e-50 172.0 COG0263@1|root,COG0263@2|Bacteria,1MUBG@1224|Proteobacteria,2TRKB@28211|Alphaproteobacteria,2K0DF@204457|Sphingomonadales 204457|Sphingomonadales E Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate proB - 2.7.2.11 ko:K00931 ko00330,ko00332,ko01100,ko01130,ko01230,map00330,map00332,map01100,map01130,map01230 M00015 R00239 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase,PUA k59_1036265_1 1197477.IA57_08140 3.82e-48 162.0 COG0536@1|root,COG0536@2|Bacteria,4NEK4@976|Bacteroidetes,1HXN1@117743|Flavobacteriia 976|Bacteroidetes S An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control obg - - ko:K03979 - - - - ko00000,ko01000,ko03009 - - - GTP1_OBG,MMR_HSR1 k59_1036265_2 926559.JoomaDRAFT_2224 1.56e-25 99.8 2DMPS@1|root,32SXU@2|Bacteria,4NTIT@976|Bacteroidetes,1I41A@117743|Flavobacteriia 976|Bacteroidetes J PFAM S23 ribosomal protein - - - - - - - - - - - - 23S_rRNA_IVP k59_696055_1 1469245.JFBG01000013_gene1945 8.75e-116 345.0 COG0056@1|root,COG0056@2|Bacteria,1MUG7@1224|Proteobacteria,1RP4V@1236|Gammaproteobacteria,1WVYR@135613|Chromatiales 135613|Chromatiales C Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit atpA - 3.6.3.14 ko:K02111 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - - ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N k59_922201_1 105559.Nwat_0327 2.83e-14 70.9 COG0724@1|root,COG0724@2|Bacteria,1N6VR@1224|Proteobacteria,1SCKA@1236|Gammaproteobacteria,1WYKM@135613|Chromatiales 135613|Chromatiales S RNA-binding protein - - - - - - - - - - - - RRM_1 k59_1318152_1 1121087.AUCK01000001_gene2979 3.54e-27 111.0 COG0133@1|root,COG0133@2|Bacteria,1TPI3@1239|Firmicutes,4H9WC@91061|Bacilli,1ZCBT@1386|Bacillus 91061|Bacilli E The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine trpB GO:0000162,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.2.1.20,5.3.1.24 ko:K01696,ko:K01817 ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230 M00023 R00674,R02340,R02722,R03509 RC00209,RC00210,RC00700,RC00701,RC00945,RC02868 ko00000,ko00001,ko00002,ko01000 - - iYO844.BSU22640 PALP k59_1318152_2 926569.ANT_05910 3.47e-15 73.6 COG0135@1|root,COG0135@2|Bacteria,2G6QB@200795|Chloroflexi 200795|Chloroflexi E Belongs to the TrpF family trpF - 5.3.1.24 ko:K01817 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R03509 RC00945 ko00000,ko00001,ko00002,ko01000 - - - PRAI k59_1374661_1 402881.Plav_1280 8.66e-52 185.0 COG0495@1|root,COG0495@2|Bacteria,1MV47@1224|Proteobacteria,2TQPK@28211|Alphaproteobacteria,1JNIA@119043|Rhodobiaceae 28211|Alphaproteobacteria J Leucyl-tRNA synthetase, Domain 2 leuS GO:0003674,GO:0003824,GO:0004812,GO:0004823,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006429,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.4 ko:K01869 ko00970,map00970 M00359,M00360 R03657 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - Anticodon_1,tRNA-synt_1,tRNA-synt_1_2 k59_1543914_1 441620.Mpop_0066 4.73e-23 92.8 COG0346@1|root,COG0346@2|Bacteria,1RH8G@1224|Proteobacteria,2U9BR@28211|Alphaproteobacteria,1JV2R@119045|Methylobacteriaceae 28211|Alphaproteobacteria E COG0346 Lactoylglutathione lyase and related lyases - - - - - - - - - - - - Glyoxalase k59_1543914_2 1341646.CBMO010000066_gene1445 2.07e-24 99.4 COG1028@1|root,COG1028@2|Bacteria,2GKI2@201174|Actinobacteria,235H3@1762|Mycobacteriaceae 201174|Actinobacteria IQ COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - - - - - - - - - - - adh_short,adh_short_C2 k59_1430318_1 717774.Marme_0243 1.52e-36 127.0 COG0091@1|root,COG0091@2|Bacteria,1RH0W@1224|Proteobacteria,1S5XT@1236|Gammaproteobacteria,1XK4T@135619|Oceanospirillales 135619|Oceanospirillales J The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome rplV - - ko:K02890 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L22 k59_1430318_2 159087.Daro_0325 3.7e-07 50.8 COG0092@1|root,COG0092@2|Bacteria,1MUAI@1224|Proteobacteria,2VHQN@28216|Betaproteobacteria,2KVIT@206389|Rhodocyclales 206389|Rhodocyclales J Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation rpsC - - ko:K02982 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - KH_2,Ribosomal_S3_C k59_1487888_1 1131266.ARWQ01000002_gene512 1.21e-96 300.0 COG0644@1|root,COG2440@1|root,arCOG00570@2157|Archaea,arCOG01984@2157|Archaea,41SXJ@651137|Thaumarchaeota 651137|Thaumarchaeota C Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains - - - ko:K00313 - - - - ko00000,ko01000 - - - - k59_977775_1 251221.35211061 9.29e-52 184.0 COG2374@1|root,COG2374@2|Bacteria,1GHB9@1117|Cyanobacteria 1117|Cyanobacteria G Endonuclease Exonuclease phosphatase - - - ko:K07004 - - - - ko00000 - - - DUF5017,Endonuclease_1,Exo_endo_phos,TIG k59_1487893_1 521098.Aaci_1303 1.81e-14 79.7 COG0564@1|root,COG0564@2|Bacteria,1TPCM@1239|Firmicutes,4HBG2@91061|Bacilli,2782F@186823|Alicyclobacillaceae 91061|Bacilli J Responsible for synthesis of pseudouridine from uracil rluD GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360 5.4.99.23 ko:K06180 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2,S4 k59_244039_1 1122194.AUHU01000004_gene1326 1.04e-09 57.8 COG1704@1|root,COG1704@2|Bacteria,1MVH0@1224|Proteobacteria,1RP1N@1236|Gammaproteobacteria,464MJ@72275|Alteromonadaceae 1236|Gammaproteobacteria S LemA family lemA - - ko:K03744 - - - - ko00000 - - - LemA k59_1147914_1 83406.HDN1F_19720 2.85e-20 85.5 COG0633@1|root,COG0633@2|Bacteria,1N261@1224|Proteobacteria,1S9CU@1236|Gammaproteobacteria 1236|Gammaproteobacteria C 2Fe-2S iron-sulfur cluster binding domain - - - ko:K04755 - - - - ko00000 - - - Fer2 k59_1147914_2 1172185.KB911534_gene2602 1.17e-50 177.0 COG2124@1|root,COG2124@2|Bacteria,2GJ8V@201174|Actinobacteria,4FUMF@85025|Nocardiaceae 201174|Actinobacteria Q Cytochrome P450 - - - - - - - - - - - - p450 k59_1543944_1 1449351.RISW2_17110 5.23e-29 120.0 COG2931@1|root,COG3210@1|root,COG2931@2|Bacteria,COG3210@2|Bacteria,1R8UF@1224|Proteobacteria,2UGWH@28211|Alphaproteobacteria 28211|Alphaproteobacteria QU Parallel beta-helix repeats - - - - - - - - - - - - - k59_131442_1 391587.KAOT1_08503 1.35e-121 371.0 COG2838@1|root,COG2838@2|Bacteria,4NFV1@976|Bacteroidetes,1HXKQ@117743|Flavobacteriia 976|Bacteroidetes C Isocitrate dehydrogenase icd - 1.1.1.42 ko:K00031 ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146 M00009,M00010,M00173,M00740 R00267,R00268,R01899 RC00001,RC00084,RC00114,RC00626,RC02801 br01601,ko00000,ko00001,ko00002,ko01000 - - - IDH k59_1430360_1 658612.MD26_15555 5.21e-12 71.2 COG2199@1|root,COG3706@2|Bacteria,1RC1J@1224|Proteobacteria,1S2CD@1236|Gammaproteobacteria 1236|Gammaproteobacteria T Diguanylate cyclase - - - - - - - - - - - - CHASE,GGDEF,PAS,PAS_3,PAS_9 k59_244056_1 158500.BV97_03607 9.09e-87 261.0 COG1414@1|root,COG1414@2|Bacteria,1RA2W@1224|Proteobacteria,2U0RW@28211|Alphaproteobacteria,2K3WV@204457|Sphingomonadales 204457|Sphingomonadales K Bacterial transcriptional regulator - - - - - - - - - - - - HTH_IclR,IclR k59_1712979_1 203122.Sde_1670 5.76e-36 127.0 COG0560@1|root,COG0560@2|Bacteria,1MZPG@1224|Proteobacteria,1RRRU@1236|Gammaproteobacteria,465E1@72275|Alteromonadaceae 1236|Gammaproteobacteria E phosphoserine phosphatase thrH - 2.7.1.39,3.1.3.3 ko:K02203 ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00680,map01100,map01110,map01120,map01130,map01230 M00018 R00582,R01771 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - HAD,Hydrolase k59_75761_1 314278.NB231_15008 1.49e-92 281.0 COG1638@1|root,COG1638@2|Bacteria,1PER4@1224|Proteobacteria,1RSR0@1236|Gammaproteobacteria 1236|Gammaproteobacteria G COG1638 TRAP-type C4-dicarboxylate transport system, periplasmic component - - - - - - - - - - - - DctP k59_1204761_1 9031.ENSGALP00000014855 8.48e-19 92.4 KOG1584@1|root,KOG1584@2759|Eukaryota,39XXS@33154|Opisthokonta,3BAJV@33208|Metazoa,3CSHX@33213|Bilateria,48878@7711|Chordata,48W0K@7742|Vertebrata,4GSIW@8782|Aves 33208|Metazoa S Belongs to the sulfotransferase 1 family SULT2B1 GO:0000103,GO:0003674,GO:0003676,GO:0003824,GO:0004027,GO:0005488,GO:0005496,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006066,GO:0006082,GO:0006139,GO:0006163,GO:0006629,GO:0006725,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008146,GO:0008150,GO:0008152,GO:0008202,GO:0008203,GO:0008285,GO:0008289,GO:0009117,GO:0009150,GO:0009259,GO:0009987,GO:0015485,GO:0016125,GO:0016740,GO:0016782,GO:0019637,GO:0019693,GO:0030856,GO:0030858,GO:0032934,GO:0033865,GO:0033875,GO:0034032,GO:0034035,GO:0034641,GO:0036094,GO:0042127,GO:0042562,GO:0043178,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045595,GO:0045597,GO:0045604,GO:0045606,GO:0045682,GO:0045684,GO:0046483,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050294,GO:0050427,GO:0050789,GO:0050793,GO:0050794,GO:0051094,GO:0051239,GO:0055086,GO:0065007,GO:0071704,GO:0072521,GO:0097159,GO:1901135,GO:1901360,GO:1901363,GO:1901564,GO:1901615,GO:1902652,GO:1990239,GO:2000026 2.8.2.2 ko:K01015 ko00140,map00140 - R00629,R03405,R08977,R08978 RC00007,RC00231,RC00341 ko00000,ko00001,ko01000 - - - Sulfotransfer_1 k59_244084_1 316407.85676064 9.37e-118 346.0 COG0151@1|root,COG0151@2|Bacteria,1MUAH@1224|Proteobacteria,1RNS4@1236|Gammaproteobacteria,3XNXC@561|Escherichia 1236|Gammaproteobacteria F Belongs to the GARS family purD GO:0000166,GO:0003674,GO:0003824,GO:0004637,GO:0005488,GO:0005524,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016874,GO:0016879,GO:0016887,GO:0017076,GO:0017111,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0033554,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0050896,GO:0051716,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.3.2.6,6.3.4.13 ko:K01945,ko:K13713 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04144,R04591 RC00064,RC00090,RC00162,RC00166 ko00000,ko00001,ko00002,ko01000 - - iECNA114_1301.ECNA114_3417,iECSF_1327.ECSF_3859,iJN746.PP_4823,iPC815.YPO3729 GARS_A,GARS_C,GARS_N k59_357927_1 1380600.AUYN01000006_gene313 1.4e-72 239.0 COG0760@1|root,COG0760@2|Bacteria,4NDZZ@976|Bacteroidetes,1HXT3@117743|Flavobacteriia 976|Bacteroidetes O Peptidylprolyl isomerase ppiD - 5.2.1.8 ko:K01802,ko:K03770 - - - - ko00000,ko01000,ko03110 - - - Rotamase_2,Rotamase_3,SurA_N_2 k59_866620_1 319224.Sputcn32_3944 2.88e-24 106.0 COG3677@1|root,COG3677@2|Bacteria,1N87H@1224|Proteobacteria,1RS9H@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Tn7-like transposition protein D - - - - - - - - - - - - TniQ,TnsD k59_1487957_1 595460.RRSWK_00414 2.54e-55 186.0 COG0665@1|root,COG0665@2|Bacteria,2IX78@203682|Planctomycetes 203682|Planctomycetes C FAD dependent oxidoreductase - - 1.4.5.1 ko:K00285 ko00360,map00360 - R01374,R09493 RC00006,RC00025 ko00000,ko00001,ko01000 - - - DAO k59_1487957_2 296587.XP_002503739.1 3.92e-23 96.7 2CY1Q@1|root,2S1CE@2759|Eukaryota 2759|Eukaryota S Sulfite exporter TauE/SafE - - - - - - - - - - - - TauE k59_977837_2 247634.GPB2148_2037 3.88e-09 60.1 COG1228@1|root,COG1228@2|Bacteria,1MVAF@1224|Proteobacteria,1RQRP@1236|Gammaproteobacteria,1J8WE@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria Q COG1228 Imidazolonepropionase and related amidohydrolases - - - - - - - - - - - - Amidohydro_1 k59_413684_1 436308.Nmar_1269 1.97e-48 165.0 COG0477@1|root,arCOG00130@2157|Archaea 2157|Archaea EGP Major facilitator superfamily - - - ko:K08153 - M00717 - - ko00000,ko00002,ko02000 2.A.1.2.8 - - MFS_1,PUCC k59_413684_2 1229909.NSED_07115 6.88e-72 244.0 COG2132@1|root,COG3391@1|root,COG3794@1|root,arCOG02562@2157|Archaea,arCOG02926@2157|Archaea,arCOG03914@2157|Archaea 2157|Archaea Q Multicopper - - - - - - - - - - - - Lactonase k59_75786_1 935863.AWZR01000001_gene1928 5.12e-98 297.0 COG0439@1|root,COG0439@2|Bacteria,1MU4H@1224|Proteobacteria,1RMNB@1236|Gammaproteobacteria,1X43Q@135614|Xanthomonadales 135614|Xanthomonadales I An AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism accC - 6.3.4.14,6.4.1.2 ko:K01961 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04385 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 - - - Biotin_carb_C,Biotin_carb_N,CPSase_L_D2 k59_1091648_1 1088721.NSU_1738 6.03e-125 365.0 COG0045@1|root,COG0045@2|Bacteria,1MVCE@1224|Proteobacteria,2TRXK@28211|Alphaproteobacteria,2K12N@204457|Sphingomonadales 204457|Sphingomonadales C Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit sucC - 6.2.1.5 ko:K01903 ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374,M00620 R00405,R02404 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000 - - - ATP-grasp_2,Ligase_CoA k59_817716_2 1121374.KB891585_gene2196 2.54e-81 258.0 COG0583@1|root,COG0583@2|Bacteria,1Q531@1224|Proteobacteria,1RWPD@1236|Gammaproteobacteria 1236|Gammaproteobacteria K transcriptional regulator - - - ko:K16516 - - - - ko00000,ko03000 - - - HTH_1,LysR_substrate k59_760892_2 1246459.KB898357_gene1621 5.93e-18 81.6 COG5437@1|root,COG5437@2|Bacteria,1RH1Z@1224|Proteobacteria,2U9I4@28211|Alphaproteobacteria,4BEKC@82115|Rhizobiaceae 28211|Alphaproteobacteria S Phage tail tube protein - - - - - - - - - - - - Phage_tail_2 k59_1215951_1 1094715.CM001373_gene1842 1.35e-09 58.5 COG3220@1|root,COG3220@2|Bacteria,1MURE@1224|Proteobacteria,1RQ9H@1236|Gammaproteobacteria,1JCNU@118969|Legionellales 118969|Legionellales S Belongs to the UPF0276 family - - - ko:K09930 - - - - ko00000 - - - DUF692 k59_1777009_1 864051.BurJ1DRAFT_3667 2.96e-96 294.0 COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,2VHKU@28216|Betaproteobacteria,1KNDZ@119065|unclassified Burkholderiales 28216|Betaproteobacteria S Tripartite tricarboxylate transporter TctA family - - - ko:K07793 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.80.1 - - TctA k59_142162_1 640081.Dsui_1561 1.86e-88 279.0 COG0021@1|root,COG0021@2|Bacteria,1MUEY@1224|Proteobacteria,2VHNX@28216|Betaproteobacteria,2KV91@206389|Rhodocyclales 206389|Rhodocyclales H Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate tkt - 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 - - - Transket_pyr,Transketolase_C,Transketolase_N k59_255030_1 1123024.AUII01000001_gene2763 1.77e-06 51.6 COG0571@1|root,COG0571@2|Bacteria,2GKER@201174|Actinobacteria,4DZ7R@85010|Pseudonocardiales 201174|Actinobacteria J Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism rnc GO:0003674,GO:0003676,GO:0003723,GO:0003725,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004525,GO:0004540,GO:0005488,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0032296,GO:0034641,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:1901360,GO:1901363 3.1.26.3 ko:K03685 ko03008,ko05205,map03008,map05205 - - - ko00000,ko00001,ko01000,ko03009,ko03019,ko03036 - - - Ribonucleas_3_3,dsrm k59_255030_2 526225.Gobs_4025 2.24e-39 147.0 COG1196@1|root,COG1196@2|Bacteria,2GK93@201174|Actinobacteria,4ERQY@85013|Frankiales 201174|Actinobacteria D Required for chromosome condensation and partitioning smc GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944 - ko:K03529 - - - - ko00000,ko03036 - - - SMC_N,SMC_hinge k59_1269603_1 32042.PstZobell_08551 5.93e-23 101.0 COG0683@1|root,COG0683@2|Bacteria,1MWGW@1224|Proteobacteria,1RQ5G@1236|Gammaproteobacteria,1Z2MI@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria E Periplasmic binding protein - - - - - - - - - - - - Peripla_BP_6 k59_255038_1 452637.Oter_1387 6.39e-182 522.0 COG4146@1|root,COG4146@2|Bacteria 2|Bacteria S symporter activity - - - ko:K03307 - - - - ko00000 2.A.21 - - SSF k59_1386185_1 436229.JOEH01000008_gene4253 3.96e-39 144.0 COG0318@1|root,COG0318@2|Bacteria,2GIUC@201174|Actinobacteria,2NGHP@228398|Streptacidiphilus 201174|Actinobacteria IQ AMP-binding enzyme C-terminal domain - - - ko:K00666 - - - - ko00000,ko01000,ko01004 - - - AMP-binding,AMP-binding_C k59_1724276_1 330214.NIDE0528 1.04e-73 234.0 COG1915@1|root,COG1915@2|Bacteria 2|Bacteria E PFAM LOR SDH bifunctional enzyme conserved region - - - - - - - - - - - - Amidinotransf,Saccharop_dh_N k59_707627_1 1244869.H261_16952 6.98e-37 141.0 COG2172@1|root,COG2203@1|root,COG2208@1|root,COG2172@2|Bacteria,COG2203@2|Bacteria,COG2208@2|Bacteria,1PFBR@1224|Proteobacteria,2U1RE@28211|Alphaproteobacteria,2JZB7@204441|Rhodospirillales 204441|Rhodospirillales T Sigma factor PP2C-like phosphatases - - - - - - - - - - - - GAF_2,HATPase_c_2,SpoIIE k59_369767_1 561175.KB894093_gene2810 1.09e-11 70.1 COG3119@1|root,COG3119@2|Bacteria 2|Bacteria P arylsulfatase activity - - - ko:K01138 - - - - ko00000,ko01000 - - - HEAT_2,Sulfatase k59_1100621_1 1122137.AQXF01000002_gene421 2.59e-47 160.0 COG1073@1|root,COG1073@2|Bacteria 2|Bacteria S thiolester hydrolase activity - - 3.1.1.24,3.1.1.85 ko:K01055,ko:K02170 ko00362,ko00780,ko01100,ko01120,ko01220,map00362,map00780,map01100,map01120,map01220 M00568,M00572 R02991,R09725 RC00460,RC00461,RC00825 ko00000,ko00001,ko00002,ko01000 - - - Abhydrolase_1,Abhydrolase_6,Hydrolase_4 k59_30277_1 204773.HEAR2857 2.65e-24 95.1 COG3536@1|root,COG3536@2|Bacteria,1MZ5M@1224|Proteobacteria,2VR9K@28216|Betaproteobacteria,474DY@75682|Oxalobacteraceae 28216|Betaproteobacteria S Protein of unknown function (DUF971) - - - - - - - - - - - - DUF971 k59_30277_2 243233.MCA2015 1e-109 328.0 COG1220@1|root,COG1220@2|Bacteria,1MVK9@1224|Proteobacteria,1RMYV@1236|Gammaproteobacteria,1XE7G@135618|Methylococcales 135618|Methylococcales O this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis hslU - - ko:K03667 - - - - ko00000,ko03110 - - - AAA_2,ClpB_D2-small k59_1724290_2 1415778.JQMM01000001_gene749 5.78e-38 139.0 COG1519@1|root,COG1519@2|Bacteria,1MU9F@1224|Proteobacteria,1RNBR@1236|Gammaproteobacteria,1J4EF@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M COG1519 3-deoxy-D-manno-octulosonic-acid transferase waaA GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016740,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044464,GO:0046467,GO:0046493,GO:0071704,GO:0071944,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15 ko:K02527 ko00540,ko01100,map00540,map01100 M00060,M00080 R04658,R05074,R09763 RC00009,RC00077,RC00247 ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT30 iECNA114_1301.ECNA114_3778,iUMNK88_1353.UMNK88_4417 Glycos_transf_1,Glycos_transf_N k59_817761_1 195253.Syn6312_1632 2e-09 65.5 COG0308@1|root,COG1413@1|root,COG0308@2|Bacteria,COG1413@2|Bacteria,1G03V@1117|Cyanobacteria,1GZ6A@1129|Synechococcus 1117|Cyanobacteria E Aminopeptidase N pepN - 3.4.11.2 ko:K01256 ko00480,ko01100,map00480,map01100 - R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 - - - DUF3458,DUF3458_C,HEAT_2,Peptidase_M1 k59_1100636_1 1449049.JONW01000008_gene320 6.25e-42 156.0 COG3391@1|root,COG3391@2|Bacteria,1QU23@1224|Proteobacteria 1224|Proteobacteria S amine dehydrogenase activity - - - - - - - - - - - - BNR_6 k59_594424_1 1267535.KB906767_gene2904 9.46e-141 431.0 COG3002@1|root,COG3002@2|Bacteria 2|Bacteria P Belongs to the UPF0753 family - - - ko:K09822 - - - - ko00000 - - - DUF2309 k59_1724297_1 1123256.KB907927_gene1701 1.67e-35 134.0 COG1387@1|root,COG1387@2|Bacteria,1MYXV@1224|Proteobacteria,1RXT9@1236|Gammaproteobacteria,1X4PW@135614|Xanthomonadales 135614|Xanthomonadales L DNA polymerase beta thumb - - - - - - - - - - - - DNA_pol_B_thumb,HHH_5,HHH_8,PHP k59_1724297_2 1121085.AUCI01000016_gene2072 2.46e-23 98.6 COG4948@1|root,COG4948@2|Bacteria,1TQMS@1239|Firmicutes,4HBMX@91061|Bacilli,1ZBMS@1386|Bacillus 91061|Bacilli H Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB) menC GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009233,GO:0009234,GO:0009987,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901661,GO:1901663 4.2.1.113 ko:K02549 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116 R04031 RC01053 ko00000,ko00001,ko00002,ko01000 - - iYO844.BSU30780 MR_MLE_C,MR_MLE_N k59_197423_1 1038859.AXAU01000026_gene2329 1.48e-154 442.0 COG4608@1|root,COG4608@2|Bacteria,1NU4K@1224|Proteobacteria,2TQTV@28211|Alphaproteobacteria 28211|Alphaproteobacteria P Belongs to the ABC transporter superfamily - - - ko:K02032,ko:K10823 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00239,M00439 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 - - ABC_tran,oligo_HPY k59_423073_1 1121441.AUCX01000028_gene334 2.1e-40 136.0 COG0234@1|root,COG0234@2|Bacteria,1MZ2X@1224|Proteobacteria,42U7E@68525|delta/epsilon subdivisions,2WPZP@28221|Deltaproteobacteria,2MCH7@213115|Desulfovibrionales 28221|Deltaproteobacteria O Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter groS - - ko:K04078 - - - - ko00000,ko03029,ko03110 - - - Cpn10 k59_369806_2 1122137.AQXF01000005_gene1204 4.29e-81 244.0 COG0035@1|root,COG0035@2|Bacteria,1MV4N@1224|Proteobacteria,2TRS7@28211|Alphaproteobacteria 28211|Alphaproteobacteria F Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate upp GO:0003674,GO:0003824,GO:0004849,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006206,GO:0006213,GO:0006220,GO:0006221,GO:0006222,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008655,GO:0009058,GO:0009112,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009173,GO:0009174,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0018130,GO:0019205,GO:0019206,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0043094,GO:0043097,GO:0043174,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046049,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.4.2.9 ko:K00761 ko00240,ko01100,map00240,map01100 - R00966 RC00063 ko00000,ko00001,ko01000 - - - UPRTase k59_1499556_1 1458357.BG58_21650 8.78e-48 160.0 COG1024@1|root,COG1024@2|Bacteria,1MXBB@1224|Proteobacteria,2VICM@28216|Betaproteobacteria,1K3K2@119060|Burkholderiaceae 28216|Betaproteobacteria I Enoyl-CoA hydratase/isomerase - - - - - - - - - - - - ECH_1 k59_1499556_2 1038860.AXAP01000031_gene5718 7.2e-32 121.0 COG1960@1|root,COG1960@2|Bacteria,1MX17@1224|Proteobacteria,2TTRE@28211|Alphaproteobacteria 28211|Alphaproteobacteria I COG1960 Acyl-CoA dehydrogenases - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_1386230_1 158500.BV97_00190 3.84e-121 357.0 COG2308@1|root,COG2308@2|Bacteria,1MUAD@1224|Proteobacteria,2TRI7@28211|Alphaproteobacteria,2K23M@204457|Sphingomonadales 204457|Sphingomonadales S Circularly permuted ATP-grasp type 2 - - - - - - - - - - - - CP_ATPgrasp_2 k59_1556342_1 991905.SL003B_3157 2.5e-28 114.0 COG0329@1|root,COG0329@2|Bacteria,1MUCM@1224|Proteobacteria,2TR5W@28211|Alphaproteobacteria,4BPHZ@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria E Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) dapA - 4.3.3.7 ko:K01714 ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R10147 RC03062,RC03063 ko00000,ko00001,ko00002,ko01000 - - - DHDPS k59_1326457_1 1157708.KB907459_gene2108 1.67e-119 347.0 COG0702@1|root,COG0702@2|Bacteria,1PM6M@1224|Proteobacteria,2VMCW@28216|Betaproteobacteria 28216|Betaproteobacteria GM Nad-dependent epimerase dehydratase - - - - - - - - - - - - Epimerase k59_648354_1 396588.Tgr7_1549 2.48e-117 344.0 COG1210@1|root,COG1210@2|Bacteria,1MV5F@1224|Proteobacteria,1RNDX@1236|Gammaproteobacteria,1WW21@135613|Chromatiales 135613|Chromatiales M UTP-glucose-1-phosphate uridylyltransferase - - 2.7.7.9 ko:K00963 ko00040,ko00052,ko00500,ko00520,ko01100,ko01130,map00040,map00052,map00500,map00520,map01100,map01130 M00129,M00361,M00362,M00549 R00289 RC00002 ko00000,ko00001,ko00002,ko01000 - - - NTP_transferase k59_534006_1 56110.Oscil6304_5545 3.45e-12 71.6 COG2199@1|root,COG2905@1|root,COG4251@1|root,COG2905@2|Bacteria,COG3706@2|Bacteria,COG4251@2|Bacteria,1FZWU@1117|Cyanobacteria,1H8MG@1150|Oscillatoriales 1117|Cyanobacteria T GGDEF domain' - - - - - - - - - - - - CBS,CHASE3,GAF,GAF_2,GAF_3,GGDEF,PAS_3,PAS_4,PAS_9 k59_87441_1 533247.CRD_00736 5.36e-115 357.0 COG3119@1|root,COG3119@2|Bacteria,1G3QV@1117|Cyanobacteria,1HJZV@1161|Nostocales 1117|Cyanobacteria P Sulfatase - - 3.1.6.1 ko:K01130 ko00140,ko00600,map00140,map00600 - R03980,R04856 RC00128,RC00231 ko00000,ko00001,ko01000 - - - Sulfatase k59_817796_1 1123073.KB899241_gene2266 7.59e-34 128.0 COG1565@1|root,COG1565@2|Bacteria,1N3CJ@1224|Proteobacteria,1RYCJ@1236|Gammaproteobacteria,1X3YI@135614|Xanthomonadales 135614|Xanthomonadales S Putative S-adenosyl-L-methionine-dependent methyltransferase - - - - - - - - - - - - Methyltransf_28 k59_1386250_1 393595.ABO_2734 5.56e-12 65.5 COG1475@1|root,COG1475@2|Bacteria,1MW2E@1224|Proteobacteria,1RN65@1236|Gammaproteobacteria,1XHMA@135619|Oceanospirillales 135619|Oceanospirillales K Belongs to the ParB family parB - - ko:K03497 - - - - ko00000,ko03000,ko03036,ko04812 - - - ParBc k59_1386250_2 1226994.AMZB01000109_gene1734 9.95e-37 133.0 COG1475@1|root,COG1475@2|Bacteria,1MW2E@1224|Proteobacteria,1RN65@1236|Gammaproteobacteria,1YDHQ@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria K Belongs to the ParB family parB - - ko:K03497 - - - - ko00000,ko03000,ko03036,ko04812 - - - ParBc k59_760960_1 194439.CT1841 1.18e-12 64.7 COG0454@1|root,COG0454@2|Bacteria 2|Bacteria K -acetyltransferase - - - - - - - - - - - - Acetyltransf_1,Acetyltransf_10,Acetyltransf_7 k59_760960_2 7159.AAEL008159-PA 1.32e-16 80.5 COG1028@1|root,KOG0725@2759|Eukaryota,395BZ@33154|Opisthokonta,3BCHN@33208|Metazoa,3CYSE@33213|Bilateria,42AFF@6656|Arthropoda,3SZWK@50557|Insecta,458RU@7147|Diptera,45JVD@7148|Nematocera 33208|Metazoa Q Enoyl-(Acyl carrier protein) reductase - - - - - - - - - - - - adh_short,adh_short_C2 k59_30333_1 1042376.AFPK01000044_gene2703 1.48e-51 174.0 COG3391@1|root,COG5492@1|root,COG3391@2|Bacteria,COG5492@2|Bacteria,4NIW7@976|Bacteroidetes,1I0II@117743|Flavobacteriia,407AB@61432|unclassified Flavobacteriaceae 976|Bacteroidetes N domain, Protein - - - - - - - - - - - - - k59_1047547_1 1380600.AUYN01000001_gene2911 6.58e-25 96.3 2DEYG@1|root,2ZPSM@2|Bacteria,4NNJW@976|Bacteroidetes,1I1XW@117743|Flavobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_1047547_2 1484460.JSWG01000011_gene1731 6.33e-89 265.0 COG0242@1|root,COG0242@2|Bacteria,4NFB4@976|Bacteroidetes,1HX7M@117743|Flavobacteriia 976|Bacteroidetes J Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions def - 3.5.1.88 ko:K01462 - - - - ko00000,ko01000 - - - Pep_deformylase k59_986533_1 1120949.KB903317_gene1860 2.54e-26 112.0 COG5001@1|root,COG5001@2|Bacteria,2GIZF@201174|Actinobacteria 201174|Actinobacteria T signal transduction protein containing a membrane domain an EAL and a GGDEF domain - - - - - - - - - - - - EAL,GGDEF k59_1158281_1 366602.Caul_1667 3.84e-72 231.0 COG2267@1|root,COG2267@2|Bacteria,1QVFU@1224|Proteobacteria,2U648@28211|Alphaproteobacteria,2KGKA@204458|Caulobacterales 204458|Caulobacterales I Alpha beta hydrolase - - - - - - - - - - - - Abhydrolase_1,Abhydrolase_6 k59_1326497_1 156889.Mmc1_2934 6.43e-46 166.0 COG1246@1|root,COG1246@2|Bacteria 2|Bacteria E Belongs to the acetyltransferase family. ArgA subfamily ywlB - 1.20.4.1,2.3.1.1 ko:K00537,ko:K00619 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028 R00259 RC00004,RC00064 ko00000,ko00001,ko00002,ko01000 - - - Acetyltransf_1,Acetyltransf_7,ArsC,C_GCAxxG_C_C k59_197493_1 1122137.AQXF01000002_gene245 1.06e-88 270.0 COG0809@1|root,COG0809@2|Bacteria,1MUH3@1224|Proteobacteria,2TS0D@28211|Alphaproteobacteria 28211|Alphaproteobacteria J Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) queA GO:0002097,GO:0002099,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016853,GO:0018130,GO:0019438,GO:0034404,GO:0034470,GO:0034641,GO:0034654,GO:0034660,GO:0042455,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0051075,GO:0055086,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.4.99.17 ko:K07568 - - - - ko00000,ko01000,ko03016 - - - Queuosine_synth k59_1499621_2 1192124.LIG30_4411 2.06e-09 55.1 COG0776@1|root,COG0776@2|Bacteria,1MZ7M@1224|Proteobacteria,2VSPN@28216|Betaproteobacteria,1K7M8@119060|Burkholderiaceae 28216|Betaproteobacteria K This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control himD - - ko:K05788 - - - - ko00000,ko03032,ko03036,ko03400 - - - Bac_DNA_binding k59_1216086_1 436308.Nmar_0572 2.03e-45 159.0 COG1914@1|root,arCOG04531@2157|Archaea 2157|Archaea P COG1914 Mn2 and Fe2 transporters of the NRAMP family - - - - - - - - - - - - 5TM-5TMR_LYT,Nramp k59_1217135_1 379731.PST_1888 1.9e-31 117.0 2EM8B@1|root,33EXE@2|Bacteria,1NN8R@1224|Proteobacteria,1TFWC@1236|Gammaproteobacteria,1Z3AH@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria M Domain of unknown function (DUF3859) - - - - - - - - - - - - DUF3859 k59_818879_1 1340493.JNIF01000004_gene924 1.21e-100 320.0 COG2307@1|root,COG2308@1|root,COG2307@2|Bacteria,COG2308@2|Bacteria,3Y2FR@57723|Acidobacteria 57723|Acidobacteria S Circularly permuted ATP-grasp type 2 - - - - - - - - - - - - Alpha-E,CP_ATPgrasp_2 k59_1439869_1 1205680.CAKO01000030_gene4871 2.48e-43 159.0 COG3276@1|root,COG3276@2|Bacteria,1MWXH@1224|Proteobacteria,2TUFY@28211|Alphaproteobacteria,2JS2H@204441|Rhodospirillales 204441|Rhodospirillales J Elongation factor SelB, winged helix - - - ko:K03833 - - - - ko00000,ko03012 - - - GTP_EFTU,GTP_EFTU_D2,SelB-wing_2,SelB-wing_3 k59_1725106_1 573065.Astex_3404 6.19e-44 162.0 COG1472@1|root,COG1472@2|Bacteria,1MVIV@1224|Proteobacteria,2TS28@28211|Alphaproteobacteria,2KHQI@204458|Caulobacterales 204458|Caulobacterales G PFAM glycoside hydrolase family 3 domain protein - - 3.2.1.21 ko:K05349 ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110 - R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040 RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248 ko00000,ko00001,ko01000 - GH3 - Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C k59_1667131_2 1415778.JQMM01000001_gene659 7.84e-11 65.1 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1J56I@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T (GGDEF) domain - - - - - - - - - - - - 5TM-5TMR_LYT,EAL,GGDEF,PAS_9,dCache_1 k59_1270442_1 314287.GB2207_10633 4.61e-35 132.0 COG1109@1|root,COG1109@2|Bacteria,1MU24@1224|Proteobacteria,1RMR2@1236|Gammaproteobacteria,1J55X@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria G Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate glmM - 5.4.2.10 ko:K03431 ko00520,ko01100,ko01130,map00520,map01100,map01130 - R02060 RC00408 ko00000,ko00001,ko01000 - - - PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV k59_931555_1 572477.Alvin_0153 8.35e-25 101.0 COG0217@1|root,COG0217@2|Bacteria,1MW3X@1224|Proteobacteria,1RP5N@1236|Gammaproteobacteria,1WX1Y@135613|Chromatiales 135613|Chromatiales K transcriptional regulatory protein - - - - - - - - - - - - Transcrip_reg k59_931555_2 999141.GME_16122 2.29e-15 73.6 COG0817@1|root,COG0817@2|Bacteria,1MUJI@1224|Proteobacteria,1RQPJ@1236|Gammaproteobacteria,1XJW7@135619|Oceanospirillales 135619|Oceanospirillales L Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group ruvC - 3.1.22.4 ko:K01159 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - RuvC k59_1270445_1 1027273.GZ77_21965 1.43e-56 186.0 COG0356@1|root,COG0356@2|Bacteria,1MV87@1224|Proteobacteria,1RPHK@1236|Gammaproteobacteria,1XH68@135619|Oceanospirillales 135619|Oceanospirillales C it plays a direct role in the translocation of protons across the membrane atpB - - ko:K02108 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko03110 3.A.2.1 - - ATP-synt_A k59_1725115_1 316407.4062427 1.55e-35 122.0 2DZVA@1|root,32VJW@2|Bacteria,1N6A5@1224|Proteobacteria,1SBQ1@1236|Gammaproteobacteria,3XPTV@561|Escherichia 1236|Gammaproteobacteria - - ybjH - - - - - - - - - - - - k59_1725115_2 316407.85674775 7.92e-62 196.0 COG0561@1|root,COG0561@2|Bacteria,1Q5HK@1224|Proteobacteria,1RQ8H@1236|Gammaproteobacteria,3XN2K@561|Escherichia 1236|Gammaproteobacteria S Catalyzes the dephosphorylation of 5-amino-6-(5-phospho- D-ribitylamino)uracil, and thus could be involved in the riboflavin biosynthesis pathway. Is also able to dephosphorylate flavin mononucleotide (FMN), erythrose 4-phosphate and other phosphoric acid esters ybjI GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006766,GO:0006767,GO:0006771,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0017144,GO:0018130,GO:0019203,GO:0034641,GO:0042364,GO:0042578,GO:0042726,GO:0042727,GO:0043167,GO:0043169,GO:0043726,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0046872,GO:0050308,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 3.1.3.102,3.1.3.104,3.1.3.23 ko:K07757,ko:K20861 ko00740,ko01100,ko01110,map00740,map01100,map01110 M00125 R00548,R00804,R07280 RC00017 ko00000,ko00001,ko00002,ko01000 - - iECO103_1326.ECO103_0866 Hydrolase_3 k59_1500598_1 1129794.C427_2320 2.79e-95 288.0 COG0667@1|root,COG0667@2|Bacteria,1MWGQ@1224|Proteobacteria,1RQ4H@1236|Gammaproteobacteria,468ZT@72275|Alteromonadaceae 1236|Gammaproteobacteria C Aldo/keto reductase family pld1 - 1.1.1.122 ko:K00064 ko00051,ko00053,ko01100,ko01110,ko01120,map00051,map00053,map01100,map01110,map01120 M00114 R07675,R08926 RC00066,RC00161 ko00000,ko00001,ko00002,ko01000 - - - Aldo_ket_red k59_1439883_1 314230.DSM3645_29316 1.43e-56 184.0 COG3588@1|root,COG3588@2|Bacteria 2|Bacteria G fructose-bisphosphate aldolase fda - 4.1.2.13 ko:K01623 ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00003,M00165,M00167 R01068,R01070,R01829,R02568 RC00438,RC00439,RC00603,RC00604 ko00000,ko00001,ko00002,ko01000,ko03036,ko04131,ko04147 - - - Glycolytic k59_1439883_2 78579.XP_003663623.1 0.000191 50.4 KOG1128@1|root,KOG1128@2759|Eukaryota,38BIC@33154|Opisthokonta,3NU02@4751|Fungi,3QMS3@4890|Ascomycota,215GN@147550|Sordariomycetes,3U7GR@5139|Sordariales,3HAI8@35718|Chaetomiaceae 4751|Fungi S Tetratricopeptide repeat - GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0008150,GO:0009987,GO:0016043,GO:0031505,GO:0032991,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044464,GO:0045229,GO:0071554,GO:0071555,GO:0071840,GO:0071852 - - - - - - - - - - TPR_16,TPR_2,TPR_8 k59_1667149_1 886293.Sinac_5331 1.47e-60 204.0 COG0249@1|root,COG0249@2|Bacteria,2IY9B@203682|Planctomycetes 203682|Planctomycetes L Mismatch repair ATPase (MutS family) - - - - - - - - - - - - MutS_III,MutS_V k59_595609_1 158500.BV97_04197 2.2e-51 174.0 COG1473@1|root,COG1473@2|Bacteria,1MUIV@1224|Proteobacteria,2TR5B@28211|Alphaproteobacteria,2K0AI@204457|Sphingomonadales 204457|Sphingomonadales S amidohydrolase - - - - - - - - - - - - M20_dimer,Peptidase_M20 k59_595609_2 1144305.PMI02_02127 2.79e-31 123.0 COG2244@1|root,COG2244@2|Bacteria,1RDQG@1224|Proteobacteria,2U6PC@28211|Alphaproteobacteria,2K0Q9@204457|Sphingomonadales 204457|Sphingomonadales S Membrane protein involved in the export of O-antigen and teichoic acid - - - - - - - - - - - - Polysacc_synt,Polysacc_synt_C k59_1159301_1 95619.PM1_0210830 1.83e-79 254.0 COG1123@1|root,COG4172@2|Bacteria,1MU09@1224|Proteobacteria,1RMEI@1236|Gammaproteobacteria 1236|Gammaproteobacteria P Belongs to the ABC transporter superfamily yejF GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006857,GO:0008144,GO:0008150,GO:0015399,GO:0015405,GO:0015833,GO:0015893,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0035672,GO:0036094,GO:0042221,GO:0042493,GO:0042623,GO:0042626,GO:0042884,GO:0042886,GO:0042891,GO:0043167,GO:0043168,GO:0043492,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - ko:K13896 ko02010,map02010 M00349 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5.21,3.A.1.5.24 - - ABC_tran,oligo_HPY k59_1275174_1 1380600.AUYN01000006_gene608 5.08e-77 256.0 COG5448@1|root,COG5448@2|Bacteria,4NGRS@976|Bacteroidetes,1HZ9S@117743|Flavobacteriia 976|Bacteroidetes S Glycoside hydrolase family 24 - - - - - - - - - - - - - k59_1730187_1 1150469.RSPPHO_02434 2.03e-54 189.0 COG1538@1|root,COG1538@2|Bacteria,1MUHM@1224|Proteobacteria,2TRMD@28211|Alphaproteobacteria,2JR0A@204441|Rhodospirillales 204441|Rhodospirillales MU Evidence 2b Function of strongly homologous gene - - - - - - - - - - - - OEP k59_766771_1 502025.Hoch_4061 5.72e-74 251.0 COG0587@1|root,COG0587@2|Bacteria,1MUIF@1224|Proteobacteria,42MGP@68525|delta/epsilon subdivisions,2WIZ2@28221|Deltaproteobacteria,2YU4G@29|Myxococcales 28221|Deltaproteobacteria L DNA polymerase dnaE - 2.7.7.7 ko:K02337,ko:K14162 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon k59_886089_1 402881.Plav_2313 1.6e-274 784.0 COG0458@1|root,COG0458@2|Bacteria,1MUDZ@1224|Proteobacteria,2TQZU@28211|Alphaproteobacteria,1JN90@119043|Rhodobiaceae 28211|Alphaproteobacteria F Carbamoyl-phosphate synthetase large chain, oligomerisation domain carB - 6.3.5.5 ko:K01955 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - - CPSase_L_D2,CPSase_L_D3,MGS k59_654554_1 795955.AFRW01000003_gene1408 8.6e-41 144.0 COG0177@1|root,COG0177@2|Bacteria,2GJ01@201174|Actinobacteria,1W7ED@1268|Micrococcaceae 201174|Actinobacteria L DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate nth GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0030312,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363 4.2.99.18 ko:K10773 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - EndIII_4Fe-2S,HhH-GPD k59_715732_1 1187848.AJYQ01000035_gene2945 3.61e-44 162.0 COG0204@1|root,COG0204@2|Bacteria,1MWDY@1224|Proteobacteria,1RRXF@1236|Gammaproteobacteria,1XT85@135623|Vibrionales 135623|Vibrionales I COG0477 Permeases of the major facilitator superfamily - - - - - - - - - - - - Acyltransferase,MFS_1 k59_1222091_1 1122137.AQXF01000002_gene157 2.57e-84 272.0 COG0760@1|root,COG0760@2|Bacteria,1MWV0@1224|Proteobacteria,2TRYU@28211|Alphaproteobacteria 28211|Alphaproteobacteria O Peptidylprolyl isomerase ppiD - 5.2.1.8 ko:K01802,ko:K03770 - - - - ko00000,ko01000,ko03110 - - - Rotamase_2,SurA_N_3 k59_1222091_2 991905.SL003B_2186 1.44e-31 118.0 COG0149@1|root,COG0149@2|Bacteria,1MWK5@1224|Proteobacteria,2TS6I@28211|Alphaproteobacteria,4BQ9W@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria G Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) tpiA GO:0003674,GO:0003824,GO:0004807,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006066,GO:0006071,GO:0006081,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0018130,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019400,GO:0019405,GO:0019438,GO:0019439,GO:0019563,GO:0019637,GO:0019682,GO:0019693,GO:0019751,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044262,GO:0044270,GO:0044271,GO:0044275,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046164,GO:0046166,GO:0046174,GO:0046184,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1901615,GO:1901616 5.3.1.1 ko:K01803 ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003 R01015 RC00423 ko00000,ko00001,ko00002,ko01000,ko04147 - - - TIM k59_147626_1 1121889.AUDM01000015_gene2010 8.4e-13 75.9 COG1572@1|root,COG2911@1|root,COG3291@1|root,COG1572@2|Bacteria,COG2911@2|Bacteria,COG3291@2|Bacteria,4NDZQ@976|Bacteroidetes,1HX5A@117743|Flavobacteriia,2NS7P@237|Flavobacterium 976|Bacteroidetes S C-terminal domain of CHU protein family - - - - - - - - - - - - CHU_C,HYR,SprB k59_1507258_2 1122137.AQXF01000002_gene607 1.73e-47 156.0 COG1432@1|root,COG1432@2|Bacteria,1MUAE@1224|Proteobacteria,2TU5M@28211|Alphaproteobacteria 28211|Alphaproteobacteria L NYN domain MA20_36560 - - - - - - - - - - - NYN k59_1507259_1 1122137.AQXF01000002_gene274 1.1e-36 126.0 COG3450@1|root,COG3450@2|Bacteria,1N0F7@1224|Proteobacteria,2UG5M@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Protein of unknown function (DUF861) - - - ko:K06995 - - - - ko00000 - - - Cupin_3 k59_1507259_2 1122137.AQXF01000002_gene273 5.99e-46 151.0 2CD0I@1|root,32RWS@2|Bacteria,1N0MC@1224|Proteobacteria,2U9CM@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Domain of unknown function (DUF4399) - - - - - - - - - - - - DUF4399 k59_936951_1 556269.ACDQ01000011_gene104 6.29e-07 50.1 COG0532@1|root,COG0532@2|Bacteria,1MV26@1224|Proteobacteria,2VK2H@28216|Betaproteobacteria,4735C@75682|Oxalobacteraceae 28216|Betaproteobacteria J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex infB - - ko:K02519 - - - - ko00000,ko03012,ko03029 - - - GTP_EFTU,IF-2,IF2_N,IF2_assoc k59_936951_2 1163617.SCD_n01714 3.58e-44 147.0 COG0858@1|root,COG0858@2|Bacteria,1MZPE@1224|Proteobacteria,2VR43@28216|Betaproteobacteria 28216|Betaproteobacteria J One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA rbfA - - ko:K02834 - - - - ko00000,ko03009 - - - RBFA k59_936951_3 859657.RPSI07_2074 3.56e-21 91.3 COG0130@1|root,COG0130@2|Bacteria,1MV0N@1224|Proteobacteria,2VH97@28216|Betaproteobacteria,1K0BF@119060|Burkholderiaceae 28216|Betaproteobacteria J Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs truB - 5.4.99.25 ko:K03177 - - - - ko00000,ko01000,ko03016 - - - TruB-C_2,TruB_C_2,TruB_N k59_428863_1 401053.AciPR4_0771 2.74e-30 125.0 COG1228@1|root,COG1228@2|Bacteria,3Y539@57723|Acidobacteria,2JKT2@204432|Acidobacteriia 204432|Acidobacteriia Q Amidohydrolase family - - - - - - - - - - - - Amidohydro_1 k59_262715_1 396588.Tgr7_3033 6.76e-80 265.0 COG0067@1|root,COG0069@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,1MU7B@1224|Proteobacteria,1RN2W@1236|Gammaproteobacteria,1WWAR@135613|Chromatiales 135613|Chromatiales E glutamate synthase - - 1.4.1.13,1.4.1.14 ko:K00265 ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 - R00093,R00114,R00248 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - GATase_2,GXGXG,Glu_syn_central,Glu_synthase k59_992343_1 1294273.roselon_01778 8.15e-32 130.0 COG0709@1|root,COG1252@1|root,COG0709@2|Bacteria,COG1252@2|Bacteria,1MWFG@1224|Proteobacteria,2TR91@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Belongs to the selenophosphate synthase 1 family. Class I subfamily selD - 2.7.9.3 ko:K01008 ko00450,ko01100,map00450,map01100 - R03595 RC00002,RC02878 ko00000,ko00001,ko01000,ko03016 - - - AIRS,AIRS_C,Pyr_redox_2 k59_992343_2 1054213.HMPREF9946_04664 1.43e-28 107.0 COG3686@1|root,COG3686@2|Bacteria,1N8EA@1224|Proteobacteria,2UG4X@28211|Alphaproteobacteria 28211|Alphaproteobacteria S MAPEG family - - - - - - - - - - - - MAPEG k59_1445202_1 158500.BV97_04192 1.52e-92 296.0 COG0308@1|root,COG0308@2|Bacteria,1MUCI@1224|Proteobacteria,2TRUM@28211|Alphaproteobacteria,2K072@204457|Sphingomonadales 204457|Sphingomonadales E aminopeptidase N pepN - 3.4.11.2 ko:K01256 ko00480,ko01100,map00480,map01100 - R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 - - - DUF3458,DUF3458_C,Peptidase_M1 k59_1166018_1 1122137.AQXF01000007_gene3574 3.19e-203 573.0 COG1249@1|root,COG1249@2|Bacteria,1MU2Z@1224|Proteobacteria,2TQS7@28211|Alphaproteobacteria 28211|Alphaproteobacteria C Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family gor GO:0000166,GO:0000302,GO:0000305,GO:0003674,GO:0005488,GO:0005507,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0006950,GO:0006979,GO:0008144,GO:0008150,GO:0009507,GO:0009532,GO:0009536,GO:0009570,GO:0009987,GO:0010035,GO:0017076,GO:0019725,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042221,GO:0042592,GO:0043167,GO:0043168,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0045454,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0065007,GO:0065008,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901700 1.8.1.7 ko:K00383 ko00480,ko04918,map00480,map04918 - R00094,R00115 RC00011 ko00000,ko00001,ko01000 - - - Pyr_redox_2,Pyr_redox_dim k59_886111_1 1123037.AUDE01000005_gene3075 3.14e-30 118.0 COG0380@1|root,COG1877@1|root,COG0380@2|Bacteria,COG1877@2|Bacteria,4NGJ4@976|Bacteroidetes,1HWRA@117743|Flavobacteriia 976|Bacteroidetes G COG0380 Trehalose-6-phosphate synthase otsB - 2.4.1.15,3.1.3.12 ko:K16055 ko00500,ko01100,map00500,map01100 - R02737,R02778 RC00005,RC00017,RC00049,RC02748 ko00000,ko00001,ko01000,ko01003 - GT20 - Glyco_transf_20,Trehalose_PPase k59_886111_2 1122225.AULQ01000001_gene1443 3.23e-110 335.0 COG3387@1|root,COG3387@2|Bacteria,4NEE6@976|Bacteroidetes,1HY70@117743|Flavobacteriia 976|Bacteroidetes G COG3387 Glucoamylase and related glycosyl - - 3.2.1.3 ko:K01178 ko00500,ko01100,map00500,map01100 - R01790,R01791,R06199 - ko00000,ko00001,ko01000 - GH15 - Glyco_hydro_15 k59_93783_1 1123270.ATUR01000008_gene249 5.24e-43 155.0 COG0606@1|root,COG0606@2|Bacteria,1MU4R@1224|Proteobacteria,2TQU6@28211|Alphaproteobacteria,2K1A3@204457|Sphingomonadales 204457|Sphingomonadales O ATPase with chaperone activity - - - ko:K07391 - - - - ko00000 - - - ChlI,Mg_chelatase,Mg_chelatase_C k59_1222116_1 436308.Nmar_1103 2.1e-49 171.0 COG0322@1|root,arCOG04753@2157|Archaea,41SX9@651137|Thaumarchaeota 651137|Thaumarchaeota L TIGRFAM excinuclease ABC, C subunit - - - ko:K03703 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - GIY-YIG,UVR,UvrC_HhH_N k59_1222116_2 436308.Nmar_1102 5.81e-51 171.0 COG3794@1|root,arCOG06255@1|root,arCOG02926@2157|Archaea,arCOG06255@2157|Archaea 2157|Archaea C PFAM blue (type 1) copper domain protein - - - - - - - - - - - - Copper-bind k59_1054254_1 1229909.NSED_05710 3.88e-80 242.0 arCOG06343@1|root,arCOG06343@2157|Archaea,41SRX@651137|Thaumarchaeota 651137|Thaumarchaeota S Poly(R)-hydroxyalkanoic acid synthase subunit (PHA_synth_III_E) - - - - - - - - - - - - PHA_synth_III_E k59_1672129_1 1254432.SCE1572_46360 1.62e-105 327.0 COG2433@1|root,COG2433@2|Bacteria,1RJ1Q@1224|Proteobacteria,43CJE@68525|delta/epsilon subdivisions,2X7TT@28221|Deltaproteobacteria,2Z3N4@29|Myxococcales 28221|Deltaproteobacteria S Transposase IS66 family - - - ko:K07484 - - - - ko00000 - - - DDE_Tnp_IS66,DDE_Tnp_IS66_C,LZ_Tnp_IS66 k59_715786_1 314278.NB231_14788 1.09e-17 84.0 COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,1RPCU@1236|Gammaproteobacteria,1WWF4@135613|Chromatiales 135613|Chromatiales S ABC transporter - - - ko:K15738 - - - - ko00000,ko02000 3.A.1.120.6 - - ABC_tran,ABC_tran_CTD,ABC_tran_Xtn k59_715786_2 1122603.ATVI01000009_gene2612 7.85e-30 108.0 COG0724@1|root,COG0724@2|Bacteria 2|Bacteria K RNA recognition motif - - - - - - - - - - - - RRM_1 k59_1507299_1 1195236.CTER_0541 1.17e-97 306.0 COG3808@1|root,COG3808@2|Bacteria,1TNZI@1239|Firmicutes,248KS@186801|Clostridia,3WHVU@541000|Ruminococcaceae 186801|Clostridia C pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for hppA - 3.6.1.1 ko:K15987 ko00190,map00190 - - - ko00000,ko00001,ko01000 3.A.10.1 - - H_PPase k59_38082_1 314287.GB2207_11083 2.8e-94 288.0 COG0014@1|root,COG0014@2|Bacteria,1MUGJ@1224|Proteobacteria,1RMAY@1236|Gammaproteobacteria,1J4G6@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate proA GO:0003674,GO:0003824,GO:0004350,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016491,GO:0016620,GO:0016903,GO:0017144,GO:0018130,GO:0019752,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0055114,GO:0055129,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.2.1.41 ko:K00147 ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230 M00015 R03313 RC00684 ko00000,ko00001,ko00002,ko01000 - - iB21_1397.B21_00243,iECBD_1354.ECBD_3376,iECB_1328.ECB_00240,iECD_1391.ECD_00240,iYL1228.KPN_00280 Aldedh k59_886135_1 1229909.NSED_09865 2.42e-27 110.0 COG0301@1|root,arCOG00038@2157|Archaea,41ST5@651137|Thaumarchaeota 651137|Thaumarchaeota H Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS - - - - - - - - - - - - - k59_886135_2 436308.Nmar_0047 2.39e-33 125.0 COG1819@1|root,arCOG01393@2157|Archaea,41SZK@651137|Thaumarchaeota 651137|Thaumarchaeota G Glycosyl transferase family 1 - - - - - - - - - - - - - k59_1445253_1 1392490.JHZX01000001_gene742 1.64e-111 340.0 COG3661@1|root,COG3661@2|Bacteria,4NHE2@976|Bacteroidetes,1HZ1N@117743|Flavobacteriia 976|Bacteroidetes G Belongs to the glycosyl hydrolase 67 family aguA - 3.2.1.139 ko:K01235 - - - - ko00000,ko01000 - - - Glyco_hydro_67C,Glyco_hydro_67M,Glyco_hydro_67N k59_1782261_1 59196.RICGR_1177 5.98e-55 195.0 COG0658@1|root,COG2333@1|root,COG0658@2|Bacteria,COG2333@2|Bacteria,1MUKF@1224|Proteobacteria,1RMW6@1236|Gammaproteobacteria,1JC9Z@118969|Legionellales 118969|Legionellales S Domain of unknown function (DUF4131) comA - - ko:K02238 - M00429 - - ko00000,ko00002,ko02044 3.A.11.1,3.A.11.2 - - Competence,DUF4131,Lactamase_B k59_1507309_1 999141.GME_11937 2.54e-16 79.0 COG1429@1|root,COG1429@2|Bacteria,1MU5W@1224|Proteobacteria,1RQED@1236|Gammaproteobacteria 1236|Gammaproteobacteria H COG1429 Cobalamin biosynthesis protein CobN and related Mg-chelatases cobN - 6.6.1.2 ko:K02230 ko00860,ko01100,map00860,map01100 - R05227 RC02000 ko00000,ko00001,ko01000 - - - CobN-Mg_chel k59_1507309_2 944435.AXAJ01000009_gene1028 5.75e-26 105.0 COG0523@1|root,COG0523@2|Bacteria,1MVZV@1224|Proteobacteria,2VHAV@28216|Betaproteobacteria,1K18W@119060|Burkholderiaceae 28216|Betaproteobacteria S cobalamin biosynthesis protein CobW cobW - - ko:K02234 - - - - ko00000,ko00001 - - - CobW_C,cobW k59_93819_1 8081.XP_008431426.1 1.22e-80 256.0 KOG1406@1|root,KOG4170@1|root,KOG1406@2759|Eukaryota,KOG4170@2759|Eukaryota,38CKQ@33154|Opisthokonta,3BDZX@33208|Metazoa,3CUCP@33213|Bilateria,483XX@7711|Chordata,48ZBY@7742|Vertebrata,49WEN@7898|Actinopterygii 33208|Metazoa I Belongs to the thiolase family SCP2 GO:0000038,GO:0000062,GO:0000166,GO:0001676,GO:0002119,GO:0002164,GO:0003008,GO:0003674,GO:0003824,GO:0003988,GO:0005102,GO:0005215,GO:0005319,GO:0005488,GO:0005496,GO:0005504,GO:0005515,GO:0005548,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005740,GO:0005741,GO:0005777,GO:0005782,GO:0005783,GO:0005829,GO:0006066,GO:0006082,GO:0006139,GO:0006163,GO:0006605,GO:0006625,GO:0006629,GO:0006631,GO:0006635,GO:0006637,GO:0006694,GO:0006699,GO:0006700,GO:0006701,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006820,GO:0006869,GO:0006886,GO:0006996,GO:0007031,GO:0007275,GO:0007568,GO:0007610,GO:0007611,GO:0007612,GO:0007635,GO:0008104,GO:0008150,GO:0008152,GO:0008202,GO:0008206,GO:0008207,GO:0008289,GO:0008306,GO:0008355,GO:0008525,GO:0008526,GO:0008610,GO:0009056,GO:0009058,GO:0009062,GO:0009117,GO:0009150,GO:0009259,GO:0009719,GO:0009725,GO:0009791,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010033,GO:0010243,GO:0010817,GO:0010876,GO:0010883,GO:0010888,GO:0010893,GO:0010941,GO:0010942,GO:0012505,GO:0014070,GO:0015031,GO:0015248,GO:0015485,GO:0015711,GO:0015748,GO:0015833,GO:0015850,GO:0015914,GO:0015918,GO:0016020,GO:0016042,GO:0016043,GO:0016053,GO:0016054,GO:0016137,GO:0016138,GO:0016408,GO:0016740,GO:0016746,GO:0016747,GO:0017076,GO:0017127,GO:0017144,GO:0019216,GO:0019218,GO:0019222,GO:0019236,GO:0019395,GO:0019637,GO:0019693,GO:0019748,GO:0019751,GO:0019752,GO:0019867,GO:0019898,GO:0022611,GO:0030258,GO:0030301,GO:0030554,GO:0031090,GO:0031312,GO:0031315,GO:0031406,GO:0031907,GO:0031966,GO:0031967,GO:0031968,GO:0031974,GO:0031975,GO:0031981,GO:0032101,GO:0032355,GO:0032368,GO:0032370,GO:0032371,GO:0032373,GO:0032374,GO:0032376,GO:0032377,GO:0032379,GO:0032380,GO:0032382,GO:0032383,GO:0032385,GO:0032386,GO:0032388,GO:0032501,GO:0032502,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0032879,GO:0032934,GO:0032957,GO:0032958,GO:0032959,GO:0032991,GO:0033036,GO:0033218,GO:0033293,GO:0033365,GO:0033540,GO:0033559,GO:0033814,GO:0033865,GO:0033875,GO:0033993,GO:0034032,GO:0034440,GO:0034613,GO:0034641,GO:0034698,GO:0034699,GO:0034754,GO:0035383,GO:0036041,GO:0036042,GO:0036094,GO:0036109,GO:0036314,GO:0036315,GO:0040008,GO:0040012,GO:0040024,GO:0042048,GO:0042180,GO:0042181,GO:0042221,GO:0042445,GO:0042446,GO:0042448,GO:0042579,GO:0042802,GO:0042803,GO:0042810,GO:0042811,GO:0042886,GO:0042981,GO:0043053,GO:0043054,GO:0043065,GO:0043067,GO:0043068,GO:0043167,GO:0043168,GO:0043177,GO:0043178,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043434,GO:0043436,GO:0043574,GO:0043603,GO:0043647,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044249,GO:0044255,GO:0044281,GO:0044282,GO:0044283,GO:0044422,GO:0044424,GO:0044425,GO:0044428,GO:0044429,GO:0044438,GO:0044439,GO:0044444,GO:0044446,GO:0044455,GO:0044464,GO:0044550,GO:0045184,GO:0045540,GO:0045542,GO:0045834,GO:0045927,GO:0045940,GO:0046165,GO:0046173,GO:0046394,GO:0046395,GO:0046483,GO:0046889,GO:0046890,GO:0046907,GO:0046982,GO:0046983,GO:0048037,GO:0048518,GO:0048519,GO:0048522,GO:0048580,GO:0048582,GO:0048583,GO:0048638,GO:0048639,GO:0048856,GO:0050632,GO:0050662,GO:0050789,GO:0050793,GO:0050794,GO:0050810,GO:0050877,GO:0050890,GO:0050896,GO:0050920,GO:0051049,GO:0051050,GO:0051094,GO:0051179,GO:0051186,GO:0051234,GO:0051239,GO:0051240,GO:0051641,GO:0051649,GO:0051716,GO:0055086,GO:0055114,GO:0055115,GO:0060341,GO:0060620,GO:0061062,GO:0061063,GO:0062012,GO:0062013,GO:0065007,GO:0065008,GO:0070013,GO:0070538,GO:0070723,GO:0070727,GO:0070887,GO:0071310,GO:0071396,GO:0071397,GO:0071407,GO:0071702,GO:0071704,GO:0071705,GO:0071840,GO:0071981,GO:0072329,GO:0072330,GO:0072521,GO:0072594,GO:0072657,GO:0072659,GO:0072662,GO:0072663,GO:0080090,GO:0090181,GO:0090205,GO:0090407,GO:0097159,GO:0097305,GO:0097306,GO:0097367,GO:0098588,GO:0098805,GO:0106118,GO:0106120,GO:1901135,GO:1901137,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901373,GO:1901564,GO:1901567,GO:1901575,GO:1901576,GO:1901615,GO:1901617,GO:1901652,GO:1901657,GO:1901659,GO:1901681,GO:1901698,GO:1901700,GO:1901701,GO:1902930,GO:1902932,GO:1904069,GO:1904070,GO:1904109,GO:1904121,GO:1905952,GO:1905953,GO:1905954,GO:1990778,GO:2000026,GO:2000909,GO:2000911 2.3.1.176 ko:K08764 ko00120,ko01100,ko03320,ko04146,map00120,map01100,map03320,map04146 M00104 R03719,R04811 RC00004,RC00405,RC02725 ko00000,ko00001,ko00002,ko01000 - - - SCP2,Thiolase_C,Thiolase_N k59_485570_1 1192759.AKIB01000085_gene1337 9.59e-59 199.0 COG1680@1|root,COG1680@2|Bacteria,1P3SQ@1224|Proteobacteria,2TTI5@28211|Alphaproteobacteria,2K2KE@204457|Sphingomonadales 204457|Sphingomonadales V Beta-lactamase - - - - - - - - - - - - Beta-lactamase k59_94749_1 1370121.AUWS01000076_gene598 3.76e-18 89.0 COG1020@1|root,COG1020@2|Bacteria,2GKGU@201174|Actinobacteria,23579@1762|Mycobacteriaceae 201174|Actinobacteria I Belongs to the long-chain O-acyltransferase family - - 2.3.1.20 ko:K00635 ko00561,ko01100,map00561,map01100 M00089 R02251 RC00004,RC00041 ko00000,ko00001,ko00002,ko01000 - - - DUF1298,WES_acyltransf k59_1783229_1 930166.CD58_08290 3.61e-25 96.7 COG1366@1|root,COG1366@2|Bacteria,1MZ5N@1224|Proteobacteria,1S9QR@1236|Gammaproteobacteria 1236|Gammaproteobacteria T Anti-anti-sigma regulatory factor (Antagonist of anti-sigma factor) rsbV - - ko:K20978 ko02020,ko02025,map02020,map02025 - - - ko00000,ko00001 - - - STAS_2 k59_1223268_1 666685.R2APBS1_3849 5.69e-45 152.0 COG0461@1|root,COG0461@2|Bacteria,1MW6F@1224|Proteobacteria,1RQYG@1236|Gammaproteobacteria,1X3TD@135614|Xanthomonadales 135614|Xanthomonadales F Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) pyrE - 2.4.2.10 ko:K00762 ko00240,ko01100,map00240,map01100 M00051 R01870 RC00611 ko00000,ko00001,ko00002,ko01000 - - - Pribosyltran k59_1223268_2 379731.PST_0463 6.41e-25 100.0 COG0689@1|root,COG0689@2|Bacteria,1MVFZ@1224|Proteobacteria,1RNTB@1236|Gammaproteobacteria,1Z0DU@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria J Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates rph GO:0003674,GO:0003824,GO:0004518,GO:0004540,GO:0006139,GO:0006396,GO:0006399,GO:0006401,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016075,GO:0016787,GO:0016788,GO:0019439,GO:0034470,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0140098,GO:1901360,GO:1901361,GO:1901575 2.7.7.56 ko:K00989 - - - - ko00000,ko01000,ko03016 - - - RNase_PH,RNase_PH_C k59_322363_1 709797.CSIRO_1595 6.15e-48 161.0 COG0500@1|root,COG2226@2|Bacteria,1MVSY@1224|Proteobacteria,2TTNQ@28211|Alphaproteobacteria,3JU9Q@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria Q methionine biosynthesis protein (MetW) metW - - - - - - - - - - - MetW k59_1055386_2 1089551.KE386572_gene2896 2.01e-05 48.5 COG5002@1|root,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,2U4EG@28211|Alphaproteobacteria,4BS11@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - CHASE,HAMP,HATPase_c,HisKA,MASE1,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg k59_716985_1 572544.Ilyop_0641 9.72e-70 226.0 COG0626@1|root,COG0626@2|Bacteria,37944@32066|Fusobacteria 32066|Fusobacteria E Psort location Cytoplasmic, score - - 2.5.1.48,4.4.1.8 ko:K01739,ko:K01760 ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00270,map00450,map00920,map01100,map01110,map01130,map01230 M00017 R00782,R00999,R01286,R01288,R02408,R02508,R03217,R03260,R04941,R04944,R04945,R04946 RC00020,RC00056,RC00069,RC00382,RC00420,RC00488,RC00710,RC01245,RC02303,RC02848,RC02866 ko00000,ko00001,ko00002,ko01000 - - - Cys_Met_Meta_PP k59_1333291_2 1121374.KB891586_gene2850 5.34e-87 270.0 COG0458@1|root,COG0458@2|Bacteria,1RFH4@1224|Proteobacteria,1S5TJ@1236|Gammaproteobacteria 1236|Gammaproteobacteria EF ATP-grasp domain - - - - - - - - - - - - ATP-grasp_3 k59_1565837_1 488538.SAR116_1306 4.62e-21 101.0 COG0457@1|root,COG0457@2|Bacteria,1MVMG@1224|Proteobacteria,2TSGE@28211|Alphaproteobacteria,4BQ5X@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria S Sulfotransferase family - - - - - - - - - - - - Sulfotransfer_3,TPR_1,TPR_11,TPR_12,TPR_16,TPR_2,TPR_6,TPR_8 k59_826904_1 1207063.P24_16597 8.8e-82 258.0 COG2759@1|root,COG2759@2|Bacteria,1MUR8@1224|Proteobacteria,2TRMM@28211|Alphaproteobacteria,2JQ9A@204441|Rhodospirillales 204441|Rhodospirillales F formate-tetrahydrofolate ligase activity fhs - 6.3.4.3 ko:K01938 ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200 M00140,M00377 R00943 RC00026,RC00111 ko00000,ko00001,ko00002,ko01000 - - - FTHFS k59_1565844_1 158500.BV97_00137 1.39e-44 155.0 COG3853@1|root,COG3853@2|Bacteria,1MY18@1224|Proteobacteria,2TU4T@28211|Alphaproteobacteria,2K07G@204457|Sphingomonadales 204457|Sphingomonadales P Toxic anion resistance - - - - - - - - - - - - TelA k59_1565844_2 158500.BV97_00138 2.49e-20 88.2 2F69V@1|root,30YT2@2|Bacteria,1RJCP@1224|Proteobacteria,2UAI2@28211|Alphaproteobacteria,2KDK3@204457|Sphingomonadales 204457|Sphingomonadales - - - - - - - - - - - - - - - k59_206695_1 1007104.SUS17_2449 2.69e-20 92.0 COG0596@1|root,COG0596@2|Bacteria,1QXWE@1224|Proteobacteria,2TXDH@28211|Alphaproteobacteria,2KENJ@204457|Sphingomonadales 204457|Sphingomonadales S Alpha/beta hydrolase family - - - - - - - - - - - - Abhydrolase_1 k59_655732_1 1167006.UWK_01954 6.42e-53 177.0 arCOG03638@1|root,2Z7NN@2|Bacteria,1R3Y6@1224|Proteobacteria,43BRR@68525|delta/epsilon subdivisions,2WMB1@28221|Deltaproteobacteria,2MI5N@213118|Desulfobacterales 28221|Deltaproteobacteria S Protein of unknown function (DUF1538) - - - - - - - - - - - - DUF1538 k59_655732_2 1348635.BBJY01000006_gene316 3.08e-66 224.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1XV2Y@135623|Vibrionales 135623|Vibrionales V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_263866_1 1348114.OM33_16965 1.73e-17 82.8 COG0810@1|root,COG0810@2|Bacteria,1N0DH@1224|Proteobacteria,1S9I7@1236|Gammaproteobacteria,2Q364@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria U Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins - - - ko:K03832 - - - - ko00000,ko02000 2.C.1.1 - - TonB_C k59_1276374_1 498211.CJA_0908 2.88e-53 182.0 COG4191@1|root,COG4191@2|Bacteria,1MWR3@1224|Proteobacteria,1RMH4@1236|Gammaproteobacteria,1FH29@10|Cellvibrio 1236|Gammaproteobacteria T His Kinase A (phosphoacceptor) domain regB - 2.7.13.3 ko:K15011 ko02020,map02020 M00523 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA k59_1783269_1 983920.Y88_0788 7.39e-27 107.0 COG0504@1|root,COG0504@2|Bacteria,1MUIT@1224|Proteobacteria,2TS4Y@28211|Alphaproteobacteria,2K005@204457|Sphingomonadales 204457|Sphingomonadales F Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates pyrG - 6.3.4.2 ko:K01937 ko00240,ko01100,map00240,map01100 M00052 R00571,R00573 RC00010,RC00074 ko00000,ko00001,ko00002,ko01000 - - - CTP_synth_N,GATase k59_1783269_2 702113.PP1Y_AT27058 7.6e-36 127.0 COG1314@1|root,COG1314@2|Bacteria,1N8MF@1224|Proteobacteria,2UCIP@28211|Alphaproteobacteria,2K5YU@204457|Sphingomonadales 204457|Sphingomonadales U Preprotein translocase subunit SecG secG - - ko:K03075 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2 - - SecG k59_1565873_1 667632.KB890176_gene4636 7.36e-98 298.0 COG0592@1|root,COG0592@2|Bacteria,1MVD9@1224|Proteobacteria,2VH9B@28216|Betaproteobacteria,1K1D0@119060|Burkholderiaceae 28216|Betaproteobacteria L Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria dnaN - 2.7.7.7 ko:K02338 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_beta,DNA_pol3_beta_2,DNA_pol3_beta_3 k59_429986_1 153721.MYP_151 1.03e-16 80.1 COG1251@1|root,COG1251@2|Bacteria,4NE44@976|Bacteroidetes,47M7X@768503|Cytophagia 976|Bacteroidetes C Nitrite and sulphite reductase 4Fe-4S - - 1.7.1.15 ko:K00362 ko00910,ko01120,map00910,map01120 M00530 R00787 RC00176 ko00000,ko00001,ko00002,ko01000 - - - Fer2_BFD,NIR_SIR,NIR_SIR_ferr,Pyr_redox_2 k59_429986_2 426355.Mrad2831_3642 1.93e-36 130.0 COG1959@1|root,COG1959@2|Bacteria,1N05H@1224|Proteobacteria,2UBZM@28211|Alphaproteobacteria,1JUM2@119045|Methylobacteriaceae 28211|Alphaproteobacteria K transcriptional regulator, Rrf2 family - - - ko:K13771 ko05132,map05132 - - - ko00000,ko00001,ko03000 - - - Rrf2 k59_429986_3 1123368.AUIS01000035_gene80 1.18e-44 152.0 COG1622@1|root,COG1622@2|Bacteria,1RHZD@1224|Proteobacteria,1S7HV@1236|Gammaproteobacteria 1236|Gammaproteobacteria C PFAM Cytochrome C oxidase subunit II - - 1.9.3.1 ko:K02275 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.4,3.D.4.6 - - COX2 k59_767921_1 323850.Shew_1174 3.55e-15 81.3 COG0457@1|root,COG0457@2|Bacteria,1MVMG@1224|Proteobacteria,1RU5N@1236|Gammaproteobacteria,2QBBB@267890|Shewanellaceae 1236|Gammaproteobacteria S Sulfotransferase domain - - - - - - - - - - - - Sulfotransfer_3,TPR_16,TPR_19,TPR_8 k59_1333326_1 1415754.JQMK01000013_gene428 2.28e-09 57.0 COG0835@1|root,COG0835@2|Bacteria,1NA8G@1224|Proteobacteria,1SCB2@1236|Gammaproteobacteria,468MN@72275|Alteromonadaceae 1236|Gammaproteobacteria NT COG0835 Chemotaxis signal transduction protein chpC - - ko:K06598 ko02020,ko02025,map02020,map02025 - - - ko00000,ko00001,ko02035 - - - CheW k59_1333326_2 1005395.CSV86_09652 6.35e-47 169.0 COG0643@1|root,COG0745@1|root,COG2198@1|root,COG0643@2|Bacteria,COG0745@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,1RMS6@1236|Gammaproteobacteria,1YVSH@136845|Pseudomonas putida group 1236|Gammaproteobacteria T Signal transduction histidine kinase chpA - - ko:K02487,ko:K06596 ko02020,ko02025,map02020,map02025 M00507 - - ko00000,ko00001,ko00002,ko01001,ko02022,ko02035 - - - CheW,H-kinase_dim,HATPase_c,Hpt,Response_reg k59_94810_1 1168059.KB899087_gene3960 4.55e-76 252.0 COG1835@1|root,COG1835@2|Bacteria,1MV2W@1224|Proteobacteria,2TRT8@28211|Alphaproteobacteria,3F0E6@335928|Xanthobacteraceae 28211|Alphaproteobacteria I Acyltransferase family - - - - - - - - - - - - Acyl_transf_3 k59_1167156_1 118161.KB235922_gene4390 1.94e-33 129.0 COG0520@1|root,COG0520@2|Bacteria,1G4XH@1117|Cyanobacteria,3VHS8@52604|Pleurocapsales 1117|Cyanobacteria E Cysteine desulfurase family protein, VC1184 subfamily - - - - - - - - - - - - Aminotran_5 k59_603980_1 870187.Thini_3085 3.29e-23 103.0 COG1948@1|root,COG4880@2|Bacteria,1PQKR@1224|Proteobacteria,1RVSQ@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Secreted protein containing C-terminal beta-propeller domain distantly related to WD-40 repeats - - - - - - - - - - - - Beta_propel,CBM_2 k59_94835_1 1185652.USDA257_c51600 6.77e-41 156.0 COG1529@1|root,COG1529@2|Bacteria,1QTTJ@1224|Proteobacteria,2TQVK@28211|Alphaproteobacteria,4BNUF@82115|Rhizobiaceae 28211|Alphaproteobacteria C Molybdopterin-binding domain of aldehyde dehydrogenase - - - - - - - - - - - - Ald_Xan_dh_C,Ald_Xan_dh_C2 k59_1395542_1 1229909.NSED_00695 4.01e-71 226.0 COG1571@1|root,arCOG01115@2157|Archaea,41S9G@651137|Thaumarchaeota 651137|Thaumarchaeota J ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA tiaS - 6.3.4.22 ko:K06932 - - - - ko00000,ko01000,ko03016 - - - DUF1743 k59_938219_1 522772.Dacet_1460 4.15e-26 103.0 COG2801@1|root,COG2801@2|Bacteria 2|Bacteria L transposition - - - ko:K07497 - - - - ko00000 - - - HTH_21,HTH_Tnp_1,rve,rve_3 k59_938219_2 589865.DaAHT2_1836 4.67e-37 126.0 COG2963@1|root,COG2963@2|Bacteria,1MZ3D@1224|Proteobacteria,42U0I@68525|delta/epsilon subdivisions,2WR0Q@28221|Deltaproteobacteria 28221|Deltaproteobacteria L PFAM transposase IS3 IS911 family protein - - - ko:K07497 - - - - ko00000 - - - HTH_Tnp_1 k59_1731288_1 435908.IDSA_05730 5.54e-26 110.0 COG2978@1|root,COG2978@2|Bacteria,1MUJ1@1224|Proteobacteria,1RMAI@1236|Gammaproteobacteria,2QFCF@267893|Idiomarinaceae 1236|Gammaproteobacteria H Transporter ydaH - - ko:K12942 - - - - ko00000 - - - ABG_transport k59_1167171_1 713587.THITH_12795 2.45e-99 302.0 COG0516@1|root,COG0517@1|root,COG0516@2|Bacteria,COG0517@2|Bacteria,1MUJM@1224|Proteobacteria,1RMT8@1236|Gammaproteobacteria,1WXCW@135613|Chromatiales 135613|Chromatiales F Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth guaB - 1.1.1.205 ko:K00088 ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 M00050 R01130,R08240 RC00143,RC02207 ko00000,ko00001,ko00002,ko01000,ko04147 - - - CBS,IMPDH k59_1333380_1 1386089.N865_13335 6.29e-69 236.0 COG2902@1|root,COG2902@2|Bacteria,2GK0C@201174|Actinobacteria,4FG36@85021|Intrasporangiaceae 201174|Actinobacteria E Dehydrogenase gdh - 1.4.1.2 ko:K15371 ko00220,ko00250,ko00430,ko00910,ko01100,map00220,map00250,map00430,map00910,map01100 - R00243 RC00006,RC02799 ko00000,ko00001,ko01000 - - - Bac_GDH k59_1107853_2 1088721.NSU_2097 2.46e-48 162.0 COG4117@1|root,COG4117@2|Bacteria,1MX97@1224|Proteobacteria,2U0ZF@28211|Alphaproteobacteria,2K0DE@204457|Sphingomonadales 204457|Sphingomonadales C Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein) - - - - - - - - - - - - Ni_hydr_CYTB k59_1738612_1 1121324.CLIT_4c00250 3.87e-35 137.0 COG0475@1|root,COG0569@1|root,COG0475@2|Bacteria,COG0569@2|Bacteria,1TS32@1239|Firmicutes,247XW@186801|Clostridia,25RVB@186804|Peptostreptococcaceae 186801|Clostridia P CPA2 family - - - - - - - - - - - - Na_H_Exchanger k59_1738625_1 162425.CADANIAP00002695 3.14e-99 300.0 COG1804@1|root,KOG3957@2759|Eukaryota,39UR2@33154|Opisthokonta,3NZAI@4751|Fungi,3QQM3@4890|Ascomycota,20K5G@147545|Eurotiomycetes 4751|Fungi I CoA-transferase family III - - - - - - - - - - - - CoA_transf_3 k59_1230317_2 1229909.NSED_03365 4.23e-91 277.0 COG4301@1|root,arCOG06722@2157|Archaea,41SWR@651137|Thaumarchaeota 651137|Thaumarchaeota S Histidine-specific methyltransferase, SAM-dependent - - - - - - - - - - - - Methyltransf_33 k59_46310_1 745310.G432_13010 3.7e-91 290.0 COG4773@1|root,COG4773@2|Bacteria,1QTXJ@1224|Proteobacteria,2TW5E@28211|Alphaproteobacteria,2K17T@204457|Sphingomonadales 204457|Sphingomonadales P TonB-dependent Receptor Plug Domain - - - - - - - - - - - - Plug,TonB_dep_Rec k59_894972_1 1380394.JADL01000002_gene1249 1.53e-43 144.0 2DBV6@1|root,32TY6@2|Bacteria,1N0TC@1224|Proteobacteria,2UCAJ@28211|Alphaproteobacteria,2JXVR@204441|Rhodospirillales 204441|Rhodospirillales S Nitrile hydratase beta subunit - - 4.2.1.84 ko:K20807 ko00364,ko00380,ko00627,ko00643,ko01120,map00364,map00380,map00627,map00643,map01120 - R04020,R05379,R05596,R07780,R07854 RC00483,RC01345,RC01432 ko00000,ko00001,ko01000 - - - NHase_beta k59_894972_2 1232683.ADIMK_2570 3.03e-21 91.3 2BZ0R@1|root,2Z7U0@2|Bacteria,1MX37@1224|Proteobacteria,1RQFN@1236|Gammaproteobacteria,46AKE@72275|Alteromonadaceae 1236|Gammaproteobacteria S Nitrile hydratase, alpha chain scnC - 3.5.5.8,4.2.1.84 ko:K01721,ko:K20762 ko00364,ko00380,ko00627,ko00643,ko01120,map00364,map00380,map00627,map00643,map01120 - R02828,R04020,R05379,R05596,R07780,R07854 RC00483,RC00792,RC01345,RC01432 ko00000,ko00001,ko01000 - - - NHase_alpha k59_724833_1 1128421.JAGA01000002_gene877 2.07e-62 217.0 COG0085@1|root,COG0085@2|Bacteria,2NNM9@2323|unclassified Bacteria 2|Bacteria K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoB GO:0000428,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0030880,GO:0032991,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0061695,GO:0071944,GO:1902494,GO:1990234 2.7.7.6 ko:K03043 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7 k59_1626108_1 926569.ANT_20060 1.19e-23 104.0 COG4409@1|root,COG4409@2|Bacteria 2|Bacteria G exo-alpha-(2->6)-sialidase activity - - - - - - - - - - - - ASH,BNR_2,CBM_35,DUF1080,PKD k59_156654_2 864051.BurJ1DRAFT_1739 3.61e-19 83.6 2AHZN@1|root,318CZ@2|Bacteria,1Q06K@1224|Proteobacteria,2W4WA@28216|Betaproteobacteria,1KNW5@119065|unclassified Burkholderiales 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_156654_3 1177154.Y5S_03492 1.14e-09 59.3 COG0457@1|root,COG0457@2|Bacteria,1NB8N@1224|Proteobacteria,1SEZN@1236|Gammaproteobacteria,1XMRE@135619|Oceanospirillales 135619|Oceanospirillales S FOG TPR repeat - - - - - - - - - - - - TPR_11,TPR_6,TPR_8 k59_1626118_1 882.DVU_0656 5.99e-12 61.6 COG2835@1|root,COG2835@2|Bacteria,1Q1BG@1224|Proteobacteria,42WTN@68525|delta/epsilon subdivisions,2WSI9@28221|Deltaproteobacteria,2MD2I@213115|Desulfovibrionales 28221|Deltaproteobacteria S Belongs to the UPF0434 family - - - ko:K09791 - - - - ko00000 - - - Trm112p k59_1626118_2 1313301.AUGC01000003_gene2099 5.75e-60 194.0 COG2877@1|root,COG2877@2|Bacteria,4NENN@976|Bacteroidetes 976|Bacteroidetes M Belongs to the KdsA family - - 2.5.1.55 ko:K01627 ko00540,ko01100,map00540,map01100 M00063 R03254 RC00435 ko00000,ko00001,ko00002,ko01000,ko01005 - - - DAHP_synth_1 k59_945695_1 518766.Rmar_2280 9.94e-13 68.2 COG1638@1|root,COG1638@2|Bacteria,4NGV4@976|Bacteroidetes 976|Bacteroidetes G TIGRFAM tripartite ATP-independent periplasmic transporter solute receptor, DctP family - - - - - - - - - - - - DctP k59_945695_2 1121948.AUAC01000002_gene877 1.03e-68 218.0 COG0524@1|root,COG0524@2|Bacteria,1QNWF@1224|Proteobacteria,2TT7H@28211|Alphaproteobacteria,43XH4@69657|Hyphomonadaceae 28211|Alphaproteobacteria G pfkB family carbohydrate kinase - - 2.7.1.45 ko:K00874 ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200 M00061,M00308,M00631 R01541 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - PfkB k59_724849_1 713586.KB900536_gene1841 3.95e-81 269.0 COG0067@1|root,COG0069@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,1MU7B@1224|Proteobacteria,1RN2W@1236|Gammaproteobacteria,1WWAR@135613|Chromatiales 135613|Chromatiales E glutamate synthase - - 1.4.1.13,1.4.1.14 ko:K00265 ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 - R00093,R00114,R00248 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - GATase_2,GXGXG,Glu_syn_central,Glu_synthase k59_1230343_1 1380390.JIAT01000010_gene4068 3.53e-69 226.0 COG0389@1|root,COG0389@2|Bacteria,2GKBI@201174|Actinobacteria,4CR49@84995|Rubrobacteria 84995|Rubrobacteria L IMS family HHH motif - - 2.7.7.7 ko:K02346 - - - - ko00000,ko01000,ko03400 - - - IMS,IMS_C,IMS_HHH k59_834435_1 485913.Krac_8762 1.18e-89 279.0 COG0624@1|root,COG0624@2|Bacteria,2G5IT@200795|Chloroflexi 200795|Chloroflexi E PFAM peptidase M20 - - - - - - - - - - - - M20_dimer,Peptidase_M20 k59_271921_2 1250005.PHEL85_3425 1.66e-27 110.0 COG0433@1|root,COG0433@2|Bacteria,4NU1B@976|Bacteroidetes,1ICEF@117743|Flavobacteriia,3VX6N@52959|Polaribacter 976|Bacteroidetes S Type IV secretion-system coupling protein DNA-binding domain - - - - - - - - - - - - TraG-D_C,TrwB_AAD_bind k59_1791022_2 754476.Q7A_2552 3.28e-29 120.0 COG1640@1|root,COG1640@2|Bacteria,1QTVJ@1224|Proteobacteria,1RMJW@1236|Gammaproteobacteria,45ZQG@72273|Thiotrichales 72273|Thiotrichales G 4-alpha-glucanotransferase - - 2.4.1.25 ko:K00705 ko00500,ko01100,map00500,map01100 - R05196 RC00049 ko00000,ko00001,ko01000 - GH77 - Glyco_hydro_77 k59_1174424_1 1229909.NSED_05805 5.45e-143 425.0 COG0168@1|root,COG0517@1|root,arCOG00606@2157|Archaea,arCOG04145@2157|Archaea,41SZ8@651137|Thaumarchaeota 651137|Thaumarchaeota P CBS domain - - - ko:K03498 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - - CBS,TrkH k59_1284665_2 1117315.AHCA01000002_gene3317 2.31e-30 113.0 COG0424@1|root,COG0424@2|Bacteria,1RDA9@1224|Proteobacteria,1S3TQ@1236|Gammaproteobacteria,2Q1QF@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria D COG0424 Nucleotide-binding protein implicated in inhibition of septum formation yceF GO:0003674,GO:0003824,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0047429 - ko:K06287 - - - - ko00000 - - - Maf k59_1403550_1 1120963.KB894500_gene100 4.34e-48 169.0 COG1297@1|root,COG1297@2|Bacteria,1N7SK@1224|Proteobacteria,1RNC8@1236|Gammaproteobacteria 1236|Gammaproteobacteria S oligopeptide transporter - - - - - - - - - - - - OPT k59_1403550_2 1122137.AQXF01000004_gene1722 1.47e-16 79.0 COG0534@1|root,COG0534@2|Bacteria,1MUAM@1224|Proteobacteria,2TSDU@28211|Alphaproteobacteria 28211|Alphaproteobacteria V Mate efflux family protein norM - - ko:K03327 - - - - ko00000,ko02000 2.A.66.1 - - MatE k59_945716_1 1122137.AQXF01000004_gene1431 1.14e-97 299.0 COG0168@1|root,COG0168@2|Bacteria,1MUIJ@1224|Proteobacteria,2TRPX@28211|Alphaproteobacteria 28211|Alphaproteobacteria P Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA - - - ko:K03498 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - - TrkH k59_945716_2 1122137.AQXF01000004_gene1433 1.79e-48 155.0 COG0316@1|root,COG0316@2|Bacteria,1RH6T@1224|Proteobacteria,2UBWJ@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Belongs to the HesB IscA family iscA GO:0003674,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008198,GO:0009058,GO:0009987,GO:0010467,GO:0016043,GO:0016226,GO:0018130,GO:0019438,GO:0019538,GO:0022607,GO:0031163,GO:0031974,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046148,GO:0046483,GO:0046872,GO:0046914,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051537,GO:0051540,GO:0051604,GO:0070013,GO:0071704,GO:0071840,GO:0097428,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 - ko:K13628 - - - - ko00000,ko03016 - - - Fe-S_biosyn k59_1516011_1 1122137.AQXF01000001_gene3182 2.24e-115 344.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2TQPG@28211|Alphaproteobacteria 28211|Alphaproteobacteria T COG2204 Response regulator containing CheY-like receiver AAA-type ATPase and DNA-binding domains luxO - - ko:K10912 ko02020,ko02024,ko05111,map02020,map02024,map05111 M00513 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_834451_1 1122137.AQXF01000003_gene2287 6.96e-96 295.0 COG0769@1|root,COG0769@2|Bacteria,1MU6P@1224|Proteobacteria,2TVXI@28211|Alphaproteobacteria 28211|Alphaproteobacteria M Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan murE - 6.3.2.13 ko:K01928 ko00300,ko00550,map00300,map00550 - R02788 RC00064,RC00090 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_834451_2 1122137.AQXF01000003_gene2286 3.04e-14 71.6 COG0768@1|root,COG0768@2|Bacteria,1MUNY@1224|Proteobacteria,2TSHQ@28211|Alphaproteobacteria 28211|Alphaproteobacteria M Cell division protein FtsI penicillin-binding protein 2 ftsI - 3.4.16.4 ko:K03587 ko00550,ko01501,map00550,map01501 - - - ko00000,ko00001,ko01000,ko01011,ko03036 - - - PBP_dimer,Transpeptidase k59_438664_1 1079460.ATTQ01000009_gene662 1.08e-18 90.9 COG3523@1|root,COG3523@2|Bacteria,1MV3D@1224|Proteobacteria,2TSY0@28211|Alphaproteobacteria,4BATZ@82115|Rhizobiaceae 28211|Alphaproteobacteria S ImcF-related N-terminal domain - - - ko:K11891 ko02025,ko03070,map02025,map03070 M00334 - - ko00000,ko00001,ko00002,ko02044 3.A.23.1 - - IcmF-related,IcmF_C,ImcF-related_N k59_776317_1 1121912.AUHD01000004_gene2231 3.08e-99 305.0 COG2273@1|root,COG2273@2|Bacteria,4NHP5@976|Bacteroidetes,1HZ1Z@117743|Flavobacteriia 976|Bacteroidetes G COG2273 Beta-glucanase Beta-glucan synthetase - - - - - - - - - - - - Glyco_hydro_16 k59_1682589_1 1163617.SCD_n01730 6.76e-45 167.0 COG4548@1|root,COG4548@2|Bacteria,1MVBZ@1224|Proteobacteria,2VJI0@28216|Betaproteobacteria 28216|Betaproteobacteria P von Willebrand factor (vWF) type A domain - - - ko:K02448 - - R00294 RC02794 ko00000 3.D.4.10 - - VWA_2 k59_387656_1 1242864.D187_007406 4.5e-28 117.0 COG3387@1|root,COG3387@2|Bacteria,1MV08@1224|Proteobacteria 1224|Proteobacteria G Glycoside Hydrolase - - - - - - - - - - - - Glyco_hydro_15 k59_835696_1 518766.Rmar_0782 1.4e-10 68.2 COG1843@1|root,COG1843@2|Bacteria,4PF6J@976|Bacteroidetes,1FK7T@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes N Required for flagellar hook formation. May act as a scaffolding protein - - - ko:K02389 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - FlgD,FlgD_ig k59_1285841_2 452637.Oter_2805 1.09e-36 137.0 COG0516@1|root,COG0517@1|root,COG0516@2|Bacteria,COG0517@2|Bacteria,46UC6@74201|Verrucomicrobia,3K7A8@414999|Opitutae 414999|Opitutae C IMP dehydrogenase / GMP reductase domain - - 1.1.1.205 ko:K00088 ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 M00050 R01130,R08240 RC00143,RC02207 ko00000,ko00001,ko00002,ko01000,ko04147 - - - CBS,IMPDH k59_1285843_1 1229909.NSED_03910 2.92e-09 56.6 COG0640@1|root,arCOG01686@2157|Archaea 2157|Archaea K regulatory protein, arsR - - - - - - - - - - - - HTH_20,HTH_5 k59_438682_1 1151127.KB906325_gene4572 7.11e-05 48.9 28JDP@1|root,2Z97Z@2|Bacteria,1R6U7@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_946949_1 477184.KYC_20024 2.19e-135 391.0 COG0559@1|root,COG0559@2|Bacteria,1MU25@1224|Proteobacteria,2VPNH@28216|Betaproteobacteria,3T6GX@506|Alcaligenaceae 28216|Betaproteobacteria U Belongs to the binding-protein-dependent transport system permease family - - - ko:K01997 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - BPD_transp_2 k59_946949_2 742159.HMPREF0004_0496 7.04e-31 119.0 COG0683@1|root,COG0683@2|Bacteria,1MX94@1224|Proteobacteria,2VHQ4@28216|Betaproteobacteria,3T5CN@506|Alcaligenaceae 28216|Betaproteobacteria E COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component - - - ko:K01999 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - Peripla_BP_6 k59_776346_1 983544.Lacal_0235 1.92e-71 234.0 COG1572@1|root,COG4935@1|root,COG1572@2|Bacteria,COG4935@2|Bacteria,4NIIN@976|Bacteroidetes,1HY0X@117743|Flavobacteriia 976|Bacteroidetes DZ C-terminal domain of CHU protein family - - - - - - - - - - - - CARDB,CHU_C k59_776346_2 1122225.AULQ01000007_gene2391 6.09e-38 141.0 COG3291@1|root,COG3386@1|root,COG3291@2|Bacteria,COG3386@2|Bacteria,4NDZQ@976|Bacteroidetes,1HX5A@117743|Flavobacteriia 976|Bacteroidetes M C-terminal domain of CHU protein family - - - - - - - - - - - - CHU_C,HYR,PKD,SprB k59_215148_1 1096930.L284_05395 1.84e-26 101.0 2EH03@1|root,33AS5@2|Bacteria,1R0X6@1224|Proteobacteria,2TYUY@28211|Alphaproteobacteria,2K72Z@204457|Sphingomonadales 204457|Sphingomonadales S Flagellar biosynthesis protein, FliO - - - ko:K02418 ko02040,map02040 - - - ko00000,ko00001,ko02035,ko02044 3.A.6.2 - - FliO k59_215148_2 1144305.PMI02_03575 1.37e-28 103.0 COG1886@1|root,COG1886@2|Bacteria,1N1JC@1224|Proteobacteria,2UC3S@28211|Alphaproteobacteria,2K6JH@204457|Sphingomonadales 204457|Sphingomonadales NU Type III flagellar switch regulator (C-ring) FliN C-term - - - ko:K02417 ko02030,ko02040,map02030,map02040 - - - ko00000,ko00001,ko02035,ko02044 3.A.6.2,3.A.6.3 - - FliMN_C k59_1175494_1 1380394.JADL01000002_gene1592 3.27e-40 137.0 COG5496@1|root,COG5496@2|Bacteria,1RKFT@1224|Proteobacteria,2U5DE@28211|Alphaproteobacteria,2JUEU@204441|Rhodospirillales 204441|Rhodospirillales S Thioesterase - - - - - - - - - - - - - k59_1175494_2 85643.Tmz1t_2959 1.02e-14 74.3 COG0243@1|root,COG0243@2|Bacteria,1P01N@1224|Proteobacteria,2VMWP@28216|Betaproteobacteria,2KVYZ@206389|Rhodocyclales 206389|Rhodocyclales C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - 1.17.5.1,3.1.2.25 ko:K18361 ko00360,map00360 - R07222,R07294 RC00004,RC01844,RC01903 ko00000,ko00001,ko01000 - - - Molybdopterin,Molydop_binding k59_1175498_1 1246626.BleG1_3133 1.35e-23 96.7 COG0314@1|root,COG0314@2|Bacteria,1V3V0@1239|Firmicutes,4HGZD@91061|Bacilli,1ZG9N@1386|Bacillus 91061|Bacilli H COG0314 Molybdopterin converting factor, large subunit moaE GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009144,GO:0009150,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0016740,GO:0016782,GO:0016783,GO:0018130,GO:0019538,GO:0019637,GO:0019693,GO:0030366,GO:0032324,GO:0034641,GO:0042278,GO:0043170,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046039,GO:0046128,GO:0046483,GO:0051186,GO:0051188,GO:0051189,GO:0055086,GO:0071704,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657 2.8.1.12 ko:K03635 ko00790,ko01100,ko04122,map00790,map01100,map04122 - R09395 RC02507 ko00000,ko00001,ko01000 - - - MoaE k59_776365_1 1279009.ADICEAN_00034 1.49e-50 169.0 2C8PG@1|root,32RMK@2|Bacteria,4P5DF@976|Bacteroidetes,47VYD@768503|Cytophagia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_835714_1 318167.Sfri_3225 3.37e-206 591.0 COG4773@1|root,COG4773@2|Bacteria,1NZCG@1224|Proteobacteria,1T1NA@1236|Gammaproteobacteria,2QC94@267890|Shewanellaceae 1236|Gammaproteobacteria P TonB dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,STN,TonB_dep_Rec k59_946959_1 1122137.AQXF01000003_gene2017 4.17e-87 261.0 COG0193@1|root,COG0193@2|Bacteria,1MX1P@1224|Proteobacteria,2TT6Q@28211|Alphaproteobacteria 28211|Alphaproteobacteria J The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis pth GO:0003674,GO:0003824,GO:0004045,GO:0016787,GO:0016788,GO:0052689,GO:0140098,GO:0140101 3.1.1.29 ko:K01056 - - - - ko00000,ko01000,ko03012 - - - Pept_tRNA_hydro k59_946959_2 1122137.AQXF01000003_gene2018 5.44e-42 143.0 COG1825@1|root,COG1825@2|Bacteria,1RDH0@1224|Proteobacteria,2U5P0@28211|Alphaproteobacteria 28211|Alphaproteobacteria J This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance ctc GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02897 ko03010,map03010 M00178 - - ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L25p,Ribosomal_TL5_C k59_1285883_1 1229909.NSED_02975 6.41e-24 97.1 COG0517@1|root,arCOG00606@2157|Archaea,41T8N@651137|Thaumarchaeota 651137|Thaumarchaeota S CBS domain - - - - - - - - - - - - CBS k59_1342160_1 335543.Sfum_1617 9.5e-66 219.0 COG0457@1|root,COG0457@2|Bacteria,1QXGV@1224|Proteobacteria,42RIF@68525|delta/epsilon subdivisions,2WNC6@28221|Deltaproteobacteria 28221|Deltaproteobacteria S ASPIC and UnbV - - - - - - - - - - - - UnbV_ASPIC,VCBS k59_494286_2 1121921.KB898708_gene1323 1.59e-73 228.0 COG0483@1|root,COG0483@2|Bacteria,1MUQT@1224|Proteobacteria,1RNME@1236|Gammaproteobacteria,2PN1J@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria G Inositol monophosphatase family suhB - 3.1.3.25 ko:K01092 ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070 M00131 R01185,R01186,R01187 RC00078 ko00000,ko00001,ko00002,ko01000 - - - Inositol_P k59_1574617_1 1123255.JHYS01000007_gene1643 3.95e-11 68.6 COG2132@1|root,COG2132@2|Bacteria,1MU0J@1224|Proteobacteria,2VJA1@28216|Betaproteobacteria,4AF43@80864|Comamonadaceae 28216|Betaproteobacteria Q PFAM multicopper oxidase type - - 1.3.3.5 ko:K08100 ko00860,ko01110,map00860,map01110 - R02394 RC01983 ko00000,ko00001,ko01000 - - - Cu-oxidase,Cu-oxidase_2,Cu-oxidase_3 k59_1517211_1 1229909.NSED_03265 1.35e-79 245.0 COG2084@1|root,arCOG00247@2157|Archaea,41SI2@651137|Thaumarchaeota 651137|Thaumarchaeota I NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase - - 1.1.1.31 ko:K00020 ko00280,ko01100,map00280,map01100 - R05066 RC00099 ko00000,ko00001,ko01000 - - - NAD_binding_11,NAD_binding_2 k59_1404715_1 1191523.MROS_0772 8.76e-21 94.7 COG0845@1|root,COG0845@2|Bacteria 2|Bacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - ko:K07798,ko:K15727 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.6.1.4,8.A.1,8.A.1.2.1 - - DUF3347,HlyD_D23 k59_1116865_1 1288494.EBAPG3_18310 9.35e-80 251.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2VKD8@28216|Betaproteobacteria,3721F@32003|Nitrosomonadales 28216|Betaproteobacteria T Sigma-54 interaction domain ntrX - - - - - - - - - - - HTH_8,Response_reg,Sigma54_activ_2 k59_665104_1 1218084.BBJK01000002_gene214 1.49e-54 193.0 COG2366@1|root,COG2366@2|Bacteria,1MVMH@1224|Proteobacteria,2VIWI@28216|Betaproteobacteria,1K590@119060|Burkholderiaceae 28216|Betaproteobacteria S penicillin amidase - - 3.5.1.11 ko:K01434 ko00311,ko01130,map00311,map01130 - R02170 RC00166,RC00328 ko00000,ko00001,ko01000,ko01002 - - - Penicil_amidase k59_1517223_2 436308.Nmar_1732 5.86e-78 236.0 COG1056@1|root,arCOG00972@2157|Archaea,41T7B@651137|Thaumarchaeota 651137|Thaumarchaeota H Cytidylyltransferase-like - - 2.7.7.1 ko:K00952 ko00760,ko01100,map00760,map01100 - R00137,R03005 RC00002 ko00000,ko00001,ko01000 - - - CTP_transf_like k59_947014_2 234621.RER_30570 1.84e-33 124.0 COG0396@1|root,COG0396@2|Bacteria,2GKB7@201174|Actinobacteria,4FVU5@85025|Nocardiaceae 201174|Actinobacteria O ABC transporter sufC - - ko:K09013 - - - - ko00000,ko02000 - - - ABC_tran k59_494295_1 316407.85674369 2.09e-86 275.0 COG4775@1|root,COG4775@2|Bacteria,1MU0D@1224|Proteobacteria,1RMAP@1236|Gammaproteobacteria,3XNR5@561|Escherichia 1236|Gammaproteobacteria M Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. Constitutes, with BamD, the core component of the assembly machinery bamA GO:0005575,GO:0005623,GO:0008104,GO:0008150,GO:0009279,GO:0009987,GO:0016020,GO:0016043,GO:0019867,GO:0022607,GO:0030312,GO:0030313,GO:0031224,GO:0031230,GO:0031241,GO:0031246,GO:0031975,GO:0032991,GO:0033036,GO:0034613,GO:0043163,GO:0043165,GO:0044085,GO:0044091,GO:0044425,GO:0044462,GO:0044464,GO:0045184,GO:0045229,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0061024,GO:0070727,GO:0071709,GO:0071840,GO:0071944,GO:0072657,GO:0090150,GO:0098552,GO:0098796,GO:1990063 - ko:K07277 - - - - ko00000,ko02000,ko03029 1.B.33 - - Bac_surface_Ag,POTRA k59_330935_1 1121374.KB891575_gene1330 1.84e-22 100.0 COG1629@1|root,COG4771@2|Bacteria,1MWKN@1224|Proteobacteria,1T3V3@1236|Gammaproteobacteria 1236|Gammaproteobacteria P COG1629 Outer membrane receptor proteins, mostly Fe transport - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_1574639_1 928210.CALU01000052_gene82 1.11e-49 166.0 COG1192@1|root,COG1192@2|Bacteria,1MWRE@1224|Proteobacteria,2TSJZ@28211|Alphaproteobacteria,48T53@772|Bartonellaceae 28211|Alphaproteobacteria D VirC1 protein parA1 - - ko:K03496 - - - - ko00000,ko03036,ko04812 - - - AAA_31 k59_1175581_1 1096930.L284_22270 1.3e-64 209.0 COG0614@1|root,COG0614@2|Bacteria,1RAUP@1224|Proteobacteria,2TUB0@28211|Alphaproteobacteria,2K23T@204457|Sphingomonadales 204457|Sphingomonadales P ABC-type Fe3 -hydroxamate transport system, periplasmic component - - - ko:K02016 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko02000 3.A.1.14 - - Peripla_BP_2 k59_1175581_2 158500.BV97_03520 1.97e-16 77.8 COG4206@1|root,COG4206@2|Bacteria,1MW63@1224|Proteobacteria,2TT3G@28211|Alphaproteobacteria,2K12C@204457|Sphingomonadales 204457|Sphingomonadales H receptor - - - ko:K16092 - - - - ko00000,ko02000 1.B.14.3 - - Plug,TonB_dep_Rec k59_1455639_1 1120919.AUBI01000005_gene735 4.93e-49 171.0 COG0493@1|root,COG0493@2|Bacteria,1MU2H@1224|Proteobacteria,2TQK5@28211|Alphaproteobacteria,2JR1M@204441|Rhodospirillales 204441|Rhodospirillales E Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster - - 1.3.1.1 ko:K17722 ko00240,ko00410,ko00770,ko01100,map00240,map00410,map00770,map01100 M00046 R00977,R01414,R11026 RC00072,RC00123 ko00000,ko00001,ko00002,ko01000 - - - Fer4_20,NADH_4Fe-4S,Pyr_redox_2 k59_1792151_1 1123258.AQXZ01000019_gene3277 6.51e-108 340.0 COG0653@1|root,COG0653@2|Bacteria,2GIRT@201174|Actinobacteria,4FV86@85025|Nocardiaceae 201174|Actinobacteria U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane secA GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030312,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0036094,GO:0040007,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680 - ko:K03070 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4 - - SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW k59_612909_1 1122137.AQXF01000005_gene1265 1.09e-125 376.0 COG1022@1|root,COG1022@2|Bacteria,1MU4D@1224|Proteobacteria,2U6WR@28211|Alphaproteobacteria 28211|Alphaproteobacteria I AMP-binding enzyme - - - - - - - - - - - - AMP-binding k59_1517260_1 1229909.NSED_05135 3.39e-125 371.0 COG0504@1|root,arCOG00063@2157|Archaea,41S7G@651137|Thaumarchaeota 651137|Thaumarchaeota F Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates pyrG - 6.3.4.2 ko:K01937 ko00240,ko01100,map00240,map01100 M00052 R00571,R00573 RC00010,RC00074 ko00000,ko00001,ko00002,ko01000 - - - CTP_synth_N,GATase k59_1064034_1 550540.Fbal_1856 6.56e-49 172.0 COG0073@1|root,COG0143@1|root,COG0073@2|Bacteria,COG0143@2|Bacteria,1MUBY@1224|Proteobacteria,1RMYM@1236|Gammaproteobacteria 1236|Gammaproteobacteria J Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation metG GO:0003674,GO:0003824,GO:0004812,GO:0004825,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006431,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.10 ko:K01874 ko00450,ko00970,map00450,map00970 M00359,M00360 R03659,R04773 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iEC042_1314.EC042_2346,iECUMN_1333.ECUMN_2446 Anticodon_1,tRNA-synt_1g,tRNA_bind k59_1455651_1 941449.dsx2_1647 1.34e-24 103.0 COG0343@1|root,COG0343@2|Bacteria,1MUCA@1224|Proteobacteria,42M5Y@68525|delta/epsilon subdivisions,2WIMT@28221|Deltaproteobacteria,2M9GZ@213115|Desulfovibrionales 28221|Deltaproteobacteria J Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) tgt - 2.4.2.29 ko:K00773 - - R03789,R10209 RC00063 ko00000,ko01000,ko03016 - - - TGT k59_1455651_2 926550.CLDAP_24620 2.78e-17 80.1 COG1968@1|root,COG1968@2|Bacteria,2G6F7@200795|Chloroflexi 200795|Chloroflexi V Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin uppP - 3.6.1.27 ko:K06153 ko00550,map00550 - R05627 RC00002 ko00000,ko00001,ko01000,ko01011 - - - BacA k59_387780_1 436308.Nmar_1315 5.96e-88 263.0 COG2226@1|root,arCOG04348@2157|Archaea,41SGQ@651137|Thaumarchaeota 651137|Thaumarchaeota Q ubiE/COQ5 methyltransferase family - - 2.1.1.163,2.1.1.201 ko:K03183 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116,M00117 R04990,R04993,R06859,R08774,R09736 RC00003,RC01253,RC01662 ko00000,ko00001,ko00002,ko01000 - - - Ubie_methyltran k59_835798_1 1392838.AWNM01000042_gene1515 1.23e-107 323.0 COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2VM40@28216|Betaproteobacteria,3T5T9@506|Alcaligenaceae 28216|Betaproteobacteria C CoA-transferase family III - - - - - - - - - - - - CoA_transf_3 k59_549899_1 158500.BV97_05444 3.95e-64 204.0 COG2175@1|root,COG2175@2|Bacteria,1MVI6@1224|Proteobacteria,2TVHF@28211|Alphaproteobacteria 28211|Alphaproteobacteria Q PFAM Taurine catabolism dioxygenase TauD, TfdA family MA20_18150 - - ko:K06912 ko00361,ko01120,ko01220,map00361,map01120,map01220 - R05419,R05493 RC01371,RC01372 ko00000,ko00001,ko01000 - - - TauD k59_896326_1 1168065.DOK_06819 1.41e-108 342.0 COG0744@1|root,COG0744@2|Bacteria,1NRPB@1224|Proteobacteria,1SK67@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Transglycosylase - - - - - - - - - - - - Transgly k59_1342217_1 349521.HCH_03018 1.4e-64 218.0 COG1538@1|root,COG1538@2|Bacteria,1NW1T@1224|Proteobacteria,1RPGN@1236|Gammaproteobacteria,1XHHM@135619|Oceanospirillales 135619|Oceanospirillales MU Outer membrane efflux protein - - - - - - - - - - - - OEP k59_1523910_1 56780.SYN_02163 5.91e-36 129.0 COG0801@1|root,COG0801@2|Bacteria,1MZH8@1224|Proteobacteria,42TJ2@68525|delta/epsilon subdivisions,2WQ4P@28221|Deltaproteobacteria,2MQPC@213462|Syntrophobacterales 28221|Deltaproteobacteria H 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK) folK - 2.7.6.3 ko:K00950 ko00790,ko01100,map00790,map01100 M00126,M00841 R03503 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - HPPK k59_1798834_1 436308.Nmar_0323 1.05e-65 217.0 COG0449@1|root,arCOG00057@2157|Archaea,41SFG@651137|Thaumarchaeota 651137|Thaumarchaeota M TIGRFAM glucosamine--fructose-6-phosphate aminotransferase (isomerizing) - - 2.6.1.16 ko:K00820 ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931 - R00768 RC00010,RC00163,RC02752 ko00000,ko00001,ko01000,ko01002 - - - GATase_6,SIS k59_1238018_1 1265313.HRUBRA_01812 1.03e-161 467.0 COG1053@1|root,COG1053@2|Bacteria,1MU5M@1224|Proteobacteria,1RMU2@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Belongs to the FAD-dependent oxidoreductase 2 family. FRD SDH subfamily sdhA GO:0000104,GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009055,GO:0009060,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016627,GO:0016999,GO:0017144,GO:0019752,GO:0022900,GO:0032991,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0045273,GO:0045274,GO:0045281,GO:0045282,GO:0045333,GO:0048037,GO:0050660,GO:0050662,GO:0055114,GO:0070469,GO:0070470,GO:0071704,GO:0071944,GO:0072350,GO:0097159,GO:0098796,GO:0098797,GO:0098803,GO:1901265,GO:1901363,GO:1902494,GO:1990204 1.3.5.1,1.3.5.4 ko:K00239 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134 M00009,M00011,M00149,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 - - iE2348C_1286.E2348C_0603,iJN746.PP_4191,iPC815.YPO1111 FAD_binding_2,Succ_DH_flav_C k59_842761_2 1265310.CCBD010000044_gene707 9.99e-18 82.8 COG0318@1|root,COG0318@2|Bacteria,2GJA2@201174|Actinobacteria,232FY@1762|Mycobacteriaceae 201174|Actinobacteria IQ COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II fadD19_2 - - ko:K00666 - - - - ko00000,ko01000,ko01004 - - - AMP-binding,AMP-binding_C k59_1411614_1 269796.Rru_A3437 3.57e-65 214.0 COG3178@1|root,COG3178@2|Bacteria,1MXCH@1224|Proteobacteria,2TSJD@28211|Alphaproteobacteria,2JPII@204441|Rhodospirillales 204441|Rhodospirillales S phosphotransferase related to Ser Thr protein kinases - - 2.7.1.221 ko:K07102 ko00520,ko01100,map00520,map01100 - R08968,R11024 RC00002,RC00078 ko00000,ko00001,ko01000 - - - APH k59_110338_1 316067.Geob_0758 0.000993 45.8 COG4105@1|root,COG4105@2|Bacteria,1MVS5@1224|Proteobacteria,42RV8@68525|delta/epsilon subdivisions,2WKU0@28221|Deltaproteobacteria,43UNU@69541|Desulfuromonadales 28221|Deltaproteobacteria M Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane bamD - - ko:K05807 - - - - ko00000,ko02000 1.B.33.1 - - YfiO k59_165782_2 702113.PP1Y_AT35019 1.99e-11 63.2 COG0500@1|root,COG0640@1|root,COG0640@2|Bacteria,COG2226@2|Bacteria,1NFSV@1224|Proteobacteria,2TSMV@28211|Alphaproteobacteria,2K0VB@204457|Sphingomonadales 204457|Sphingomonadales K ArsR family transcriptional regulator - - - - - - - - - - - - HTH_20,HTH_5,Methyltransf_11 k59_1010194_2 385682.AFSL01000015_gene2686 0.000458 48.5 COG2244@1|root,COG2244@2|Bacteria,4NMZI@976|Bacteroidetes,2FUSM@200643|Bacteroidia,3XJM6@558415|Marinilabiliaceae 976|Bacteroidetes S Polysaccharide biosynthesis protein - - - - - - - - - - - - Polysacc_synt,Polysacc_synt_3,Polysacc_synt_C k59_1124554_1 702113.PP1Y_AT33485 8.37e-41 143.0 COG0330@1|root,COG0330@2|Bacteria,1MV7R@1224|Proteobacteria,2TRP4@28211|Alphaproteobacteria,2K1HR@204457|Sphingomonadales 204457|Sphingomonadales O HflC and HflK could regulate a protease hflC - - ko:K04087 - M00742 - - ko00000,ko00002,ko01000 - - - Band_7 k59_1124554_2 1088721.NSU_1290 1.43e-57 186.0 COG0330@1|root,COG0330@2|Bacteria,1MUM2@1224|Proteobacteria,2TRTP@28211|Alphaproteobacteria,2K20N@204457|Sphingomonadales 204457|Sphingomonadales O HflC and HflK could encode or regulate a protease hflK - - ko:K04088 - M00742 - - ko00000,ko00002,ko01000 - - - Band_7 k59_954790_1 1122137.AQXF01000007_gene3530 9.23e-93 288.0 COG1164@1|root,COG1164@2|Bacteria,1MWYN@1224|Proteobacteria,2TR6R@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Angiotensin-converting enzyme - - 3.4.15.1 ko:K01283 ko04614,ko04924,ko05142,ko05410,map04614,map04924,map05142,map05410 - - - ko00000,ko00001,ko01000,ko01002,ko04090,ko04147 - - - Peptidase_M2 k59_1071666_1 1121861.KB899939_gene3759 8.92e-50 169.0 COG4126@1|root,COG4126@2|Bacteria 2|Bacteria E flavin adenine dinucleotide binding - - - - - - - - - - - - Asp_Glu_race k59_843784_1 448385.sce3433 3e-18 80.1 COG0432@1|root,COG0432@2|Bacteria,1RH13@1224|Proteobacteria,42TMP@68525|delta/epsilon subdivisions,2WR9C@28221|Deltaproteobacteria,2YV89@29|Myxococcales 28221|Deltaproteobacteria S Uncharacterised protein family UPF0047 - - - - - - - - - - - - UPF0047 k59_843784_2 1227739.Hsw_1985 3.09e-13 69.3 COG0406@1|root,COG0406@2|Bacteria,4NQWA@976|Bacteroidetes,47S0K@768503|Cytophagia 976|Bacteroidetes G Histidine phosphatase superfamily (branch 1) - - - - - - - - - - - - His_Phos_1 k59_1183298_1 543728.Vapar_1984 1.3e-47 173.0 COG1640@1|root,COG3280@1|root,COG1640@2|Bacteria,COG3280@2|Bacteria,1QTVJ@1224|Proteobacteria,2WGPV@28216|Betaproteobacteria,4AD3R@80864|Comamonadaceae 28216|Betaproteobacteria G SMART alpha amylase catalytic sub domain treY - 2.4.1.25,5.4.99.15 ko:K00705,ko:K06044 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R01824,R05196,R09995 RC00049 ko00000,ko00001,ko00002,ko01000 - GH13,GH77 - Alpha-amylase,Glyco_hydro_77 k59_338730_2 690850.Desaf_1141 4.3e-16 77.4 COG0192@1|root,COG0192@2|Bacteria,1MUFQ@1224|Proteobacteria,42MFM@68525|delta/epsilon subdivisions,2WIQ3@28221|Deltaproteobacteria,2M8W7@213115|Desulfovibrionales 28221|Deltaproteobacteria H Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme metK GO:0003674,GO:0003824,GO:0004478,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016740,GO:0016765,GO:0044424,GO:0044444,GO:0044464 2.5.1.6 ko:K00789 ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230 M00034,M00035,M00368,M00609 R00177,R04771 RC00021,RC01211 ko00000,ko00001,ko00002,ko01000 - - - S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N k59_784155_1 1545915.JROG01000003_gene682 4.54e-09 60.1 COG1842@1|root,COG1842@2|Bacteria,1NC7S@1224|Proteobacteria,2U6CN@28211|Alphaproteobacteria,2K2DP@204457|Sphingomonadales 204457|Sphingomonadales KT Phage shock protein A pspA - - ko:K03969 - - - - ko00000 - - - PspA_IM30 k59_954795_1 688245.CtCNB1_2843 3.01e-30 117.0 COG5514@1|root,COG5514@2|Bacteria,1MX90@1224|Proteobacteria,2VIMN@28216|Betaproteobacteria,4AA3M@80864|Comamonadaceae 28216|Betaproteobacteria S Domain of unknown function (DUF1794) - - - - - - - - - - - - DUF1794 k59_954795_2 414684.RC1_2213 1.66e-05 49.3 COG4166@1|root,COG4166@2|Bacteria,1P91R@1224|Proteobacteria,2TT6P@28211|Alphaproteobacteria,2JR7Z@204441|Rhodospirillales 204441|Rhodospirillales E Periplasmic oligopeptide-binding protein - - - ko:K15580 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00439 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 - - SBP_bac_5 k59_1690501_2 1229780.BN381_100174 1.24e-11 68.6 COG3266@1|root,COG3266@2|Bacteria 2|Bacteria GM domain, Protein - GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 - - - - - - - - - - DUF3566 k59_784165_1 1229909.NSED_03705 9.52e-123 362.0 COG1173@1|root,arCOG00749@2157|Archaea,41SFE@651137|Thaumarchaeota 651137|Thaumarchaeota P inner membrane component - - - ko:K02034 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1 k59_843814_1 234267.Acid_6986 1.14e-67 221.0 COG1032@1|root,COG1032@2|Bacteria 2|Bacteria C radical SAM domain protein - - - ko:K22318 - - - - ko00000 - - - B12-binding,Radical_SAM k59_165816_1 1163617.SCD_n02070 3.4e-60 195.0 COG0500@1|root,COG2226@2|Bacteria,1NRR4@1224|Proteobacteria,2W05F@28216|Betaproteobacteria 28216|Betaproteobacteria Q ubiE/COQ5 methyltransferase family - - 2.1.1.163,2.1.1.201 ko:K03183 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116,M00117 R04990,R04993,R06859,R08774,R09736 RC00003,RC01253,RC01662 ko00000,ko00001,ko00002,ko01000 - - - Ubie_methyltran k59_281003_1 1042377.AFPJ01000052_gene1547 7.02e-82 251.0 COG1210@1|root,COG1210@2|Bacteria,1MV5F@1224|Proteobacteria,1RNDX@1236|Gammaproteobacteria,4650D@72275|Alteromonadaceae 1236|Gammaproteobacteria M UTP-glucose-1-phosphate uridylyltransferase galU - 2.7.7.9 ko:K00963 ko00040,ko00052,ko00500,ko00520,ko01100,ko01130,map00040,map00052,map00500,map00520,map01100,map01130 M00129,M00361,M00362,M00549 R00289 RC00002 ko00000,ko00001,ko00002,ko01000 - - - NTP_transferase k59_111410_1 330214.NIDE0577 3.36e-33 128.0 COG0433@1|root,COG0433@2|Bacteria 2|Bacteria S helicase activity - - - - - - - - - - - - DUF853,DUF87 k59_111410_2 330214.NIDE0583 6.68e-11 60.1 COG2862@1|root,COG2862@2|Bacteria 2|Bacteria S Uncharacterized protein family, UPF0114 yqhA GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K03535 - - - - ko00000,ko02000 2.A.1.14.1 - - UPF0114 k59_1124581_1 1121440.AUMA01000006_gene1447 5.94e-138 417.0 COG0542@1|root,COG0542@2|Bacteria,1MV8B@1224|Proteobacteria,42M2T@68525|delta/epsilon subdivisions,2WJ2W@28221|Deltaproteobacteria,2M92I@213115|Desulfovibrionales 28221|Deltaproteobacteria O ATP-dependent Clp protease ATP-binding subunit ClpA clpA - - ko:K03694 - - - - ko00000,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N k59_501729_1 582515.KR51_00008080 1.04e-50 179.0 COG1834@1|root,COG1915@1|root,COG1834@2|Bacteria,COG1915@2|Bacteria,1G2AU@1117|Cyanobacteria 1117|Cyanobacteria E PFAM LOR SDH bifunctional enzyme conserved region - - - - - - - - - - - - Amidinotransf,Saccharop_dh_N k59_1524992_1 1485544.JQKP01000002_gene1538 2.37e-100 298.0 COG0708@1|root,COG0708@2|Bacteria,1MVII@1224|Proteobacteria,2VH7N@28216|Betaproteobacteria,44VA6@713636|Nitrosomonadales 28216|Betaproteobacteria L Endonuclease/Exonuclease/phosphatase family xthA - 3.1.11.2 ko:K01142 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - Exo_endo_phos k59_1524992_2 987059.RBXJA2T_04818 1.03e-17 82.4 COG0339@1|root,COG0339@2|Bacteria,1MU1K@1224|Proteobacteria,2VHPQ@28216|Betaproteobacteria,1KIWY@119065|unclassified Burkholderiales 28216|Betaproteobacteria E Peptidase family M3 prlC - 3.4.24.70 ko:K01414 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M3 k59_338756_1 568076.XP_007826606.1 7.54e-12 71.2 COG0086@1|root,KOG0261@2759|Eukaryota,38G14@33154|Opisthokonta,3NXKP@4751|Fungi,3QM0W@4890|Ascomycota,211ZM@147550|Sordariomycetes,3TF3X@5125|Hypocreales,3G2Y5@34397|Clavicipitaceae 4751|Fungi K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates RPO31 GO:0000428,GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005666,GO:0006139,GO:0006351,GO:0006383,GO:0006399,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009304,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0030880,GO:0031974,GO:0031981,GO:0032774,GO:0032991,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0034660,GO:0042797,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044422,GO:0044424,GO:0044428,GO:0044446,GO:0044451,GO:0044464,GO:0046483,GO:0055029,GO:0061695,GO:0070013,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0098781,GO:0140098,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234 2.7.7.6 ko:K03018,ko:K21594 ko00230,ko00240,ko01100,ko03020,ko04623,ko05169,map00230,map00240,map01100,map03020,map04623,map05169 M00181 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03029 - - - RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5 k59_1349884_1 754476.Q7A_911 6.51e-99 296.0 COG4974@1|root,COG4974@2|Bacteria,1MVAN@1224|Proteobacteria,1RMSS@1236|Gammaproteobacteria,460A2@72273|Thiotrichales 72273|Thiotrichales L Belongs to the 'phage' integrase family - - - - - - - - - - - - Phage_int_SAM_4,Phage_integrase k59_338762_1 1167006.UWK_00506 6.08e-111 334.0 COG0539@1|root,COG2183@1|root,COG0539@2|Bacteria,COG2183@2|Bacteria,1MVAV@1224|Proteobacteria,42M29@68525|delta/epsilon subdivisions,2WJ0X@28221|Deltaproteobacteria,2MI6Q@213118|Desulfobacterales 28221|Deltaproteobacteria J thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence rpsA - - ko:K02945 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - S1 k59_1799870_1 396588.Tgr7_1256 2.28e-19 87.4 COG0285@1|root,COG0285@2|Bacteria,1MVCH@1224|Proteobacteria,1RMB0@1236|Gammaproteobacteria,1WWQD@135613|Chromatiales 135613|Chromatiales H Belongs to the folylpolyglutamate synthase family - - 6.3.2.12,6.3.2.17 ko:K11754 ko00790,ko01100,map00790,map01100 M00126,M00841 R00942,R02237,R04241 RC00064,RC00090,RC00162 ko00000,ko00001,ko00002,ko01000 - - - Mur_ligase_M k59_1799870_2 247634.GPB2148_3691 1.56e-79 246.0 COG0777@1|root,COG0777@2|Bacteria,1MW8G@1224|Proteobacteria,1RNDS@1236|Gammaproteobacteria,1J4MN@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria I Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA accD GO:0001676,GO:0003674,GO:0003676,GO:0003677,GO:0003723,GO:0003729,GO:0003824,GO:0003989,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006417,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008270,GO:0008610,GO:0009058,GO:0009317,GO:0009329,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0016053,GO:0016421,GO:0016874,GO:0016885,GO:0017148,GO:0019222,GO:0019752,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032787,GO:0032991,GO:0034248,GO:0034249,GO:0042759,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046872,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0071704,GO:0072330,GO:0080090,GO:0097159,GO:1901363,GO:1901576,GO:1902494,GO:1990234,GO:2000112,GO:2000113 2.1.3.15,6.4.1.2 ko:K01963 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04386 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 - - iPC815.YPO2768,iUTI89_1310.UTI89_C2601 Carboxyl_trans k59_1124590_1 1026882.MAMP_01448 0.000102 47.0 COG3225@1|root,COG3225@2|Bacteria,1MY63@1224|Proteobacteria,1RP5E@1236|Gammaproteobacteria,461IW@72273|Thiotrichales 72273|Thiotrichales N Gliding motility protein GldG - - - - - - - - - - - - ABC_transp_aux k59_1124590_2 1353529.M899_1022 8.03e-07 52.4 COG1277@1|root,COG1277@2|Bacteria,1NZZ9@1224|Proteobacteria,42SH9@68525|delta/epsilon subdivisions,2WPWW@28221|Deltaproteobacteria 28221|Deltaproteobacteria N ABC-type transport system involved in multi-copper enzyme maturation permease component - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_2,ABC2_membrane_3,ABC_transp_aux k59_1635247_1 316274.Haur_0218 1.61e-33 132.0 COG1132@1|root,COG1132@2|Bacteria,2G7QN@200795|Chloroflexi,374U2@32061|Chloroflexia 200795|Chloroflexi V PFAM ABC transporter transmembrane region - - - - - - - - - - - - ABC_membrane,ABC_tran k59_281030_1 391587.KAOT1_07658 5.16e-28 110.0 COG5403@1|root,COG5403@2|Bacteria,4NEX0@976|Bacteroidetes,1HYHW@117743|Flavobacteriia 976|Bacteroidetes S PFAM Bacterial protein of - - - - - - - - - - - - DUF937 k59_281030_2 1172186.KB911462_gene317 4.16e-08 54.3 COG2885@1|root,COG2885@2|Bacteria,2HXT6@201174|Actinobacteria,237JV@1762|Mycobacteriaceae 201174|Actinobacteria M Belongs to the ompA family ompA GO:0003674,GO:0005215,GO:0005488,GO:0005539,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0009268,GO:0009279,GO:0009628,GO:0010447,GO:0015267,GO:0015288,GO:0015696,GO:0016020,GO:0016021,GO:0019867,GO:0022803,GO:0022829,GO:0022857,GO:0030312,GO:0030313,GO:0031224,GO:0031226,GO:0031975,GO:0034220,GO:0040007,GO:0042834,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044121,GO:0044403,GO:0044419,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044462,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0051704,GO:0055085,GO:0071705,GO:0071944,GO:0072488,GO:0097367,GO:0098655 - ko:K16191 - - - - ko00000,ko02000 1.B.6.1.3 - - BON,OmpA k59_55520_1 1238182.C882_2938 9.77e-53 169.0 COG0222@1|root,COG0222@2|Bacteria,1RGU4@1224|Proteobacteria,2U9FX@28211|Alphaproteobacteria,2JSU1@204441|Rhodospirillales 204441|Rhodospirillales J Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation rplL - - ko:K02935 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L12,Ribosomal_L12_N k59_55520_2 1122137.AQXF01000009_gene9 9.91e-20 84.7 COG0244@1|root,COG0244@2|Bacteria,1RAN5@1224|Proteobacteria,2U592@28211|Alphaproteobacteria 28211|Alphaproteobacteria J Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors rplJ GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02864 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L10 k59_1071730_1 1121413.JMKT01000016_gene16 1.12e-17 91.7 COG2199@1|root,COG2200@1|root,COG2199@2|Bacteria,COG2200@2|Bacteria,1MVJY@1224|Proteobacteria,42N7E@68525|delta/epsilon subdivisions,2WK3K@28221|Deltaproteobacteria,2M7U9@213115|Desulfovibrionales 28221|Deltaproteobacteria T TIGRFAM Diguanylate cyclase - - - - - - - - - - - - CBS,EAL,GGDEF k59_1071730_2 1121447.JONL01000001_gene492 4.28e-34 128.0 COG0112@1|root,COG0112@2|Bacteria,1MUIS@1224|Proteobacteria,42M0T@68525|delta/epsilon subdivisions,2WJ3C@28221|Deltaproteobacteria,2M9J9@213115|Desulfovibrionales 28221|Deltaproteobacteria E Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism glyA - 2.1.2.1 ko:K00600 ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523 M00140,M00141,M00346,M00532 R00945,R09099 RC00022,RC00112,RC01583,RC02958 ko00000,ko00001,ko00002,ko01000 - - - SHMT k59_1463675_1 1120983.KB894571_gene2483 3.63e-137 396.0 COG0022@1|root,COG0022@2|Bacteria,1R8KB@1224|Proteobacteria,2TRFK@28211|Alphaproteobacteria 28211|Alphaproteobacteria C Pyruvate 2-oxoglutarate dehydrogenase complex dehydrogenase (E1) component eukaryotic type beta subunit - - 1.2.4.1 ko:K00162,ko:K21417 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230 M00307 R00014,R00209,R01699,R03270 RC00004,RC00027,RC00627,RC02742,RC02744,RC02882 br01601,ko00000,ko00001,ko00002,ko01000 - - - Transket_pyr,Transketolase_C k59_1463675_2 436229.JOEH01000002_gene3425 2.81e-86 264.0 COG1071@1|root,COG1071@2|Bacteria,2GK3W@201174|Actinobacteria,2NNCT@228398|Streptacidiphilus 201174|Actinobacteria C Dehydrogenase E1 component acoA - 1.2.4.1 ko:K00161,ko:K21416 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230 M00307 R00014,R00209,R01699,R03270 RC00004,RC00027,RC00627,RC02742,RC02744,RC02882 br01601,ko00000,ko00001,ko00002,ko01000 - - - E1_dh k59_1293946_1 1240349.ANGC01000064_gene4364 5.38e-32 132.0 COG0497@1|root,COG0497@2|Bacteria,2GIVG@201174|Actinobacteria,4FVAD@85025|Nocardiaceae 201174|Actinobacteria L May be involved in recombinational repair of damaged DNA recN GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 - ko:K03631 - - - - ko00000,ko03400 - - - AAA_23,SMC_N k59_733999_1 215803.DB30_4892 8.69e-26 102.0 COG0745@1|root,COG0745@2|Bacteria,1MY2Z@1224|Proteobacteria,42PA1@68525|delta/epsilon subdivisions,2X45W@28221|Deltaproteobacteria,2YYBN@29|Myxococcales 28221|Deltaproteobacteria T Transcriptional regulatory protein, C terminal - - - - - - - - - - - - Response_reg,Trans_reg_C k59_1010275_1 1121428.DESHY_30114___1 4.09e-21 90.5 COG2131@1|root,COG2131@2|Bacteria,1V3PU@1239|Firmicutes,24HF0@186801|Clostridia,261R0@186807|Peptococcaceae 186801|Clostridia F PFAM Cytidine and deoxycytidylate deaminase zinc-binding region comEB - 3.5.4.12 ko:K01493 ko00240,ko01100,map00240,map01100 M00429 R01663 RC00074 ko00000,ko00001,ko00002,ko01000,ko02044 - - - dCMP_cyt_deam_1 k59_501757_2 366602.Caul_0160 8.49e-45 149.0 COG0346@1|root,COG0346@2|Bacteria,1N1D4@1224|Proteobacteria,2UGZ0@28211|Alphaproteobacteria,2KJTF@204458|Caulobacterales 204458|Caulobacterales E COG0346 Lactoylglutathione lyase and related lyases - - - - - - - - - - - - - k59_1071735_1 1123517.JOMR01000001_gene1588 3.95e-46 170.0 COG4232@1|root,COG4232@2|Bacteria,1MU8W@1224|Proteobacteria,1RPF7@1236|Gammaproteobacteria,45ZS2@72273|Thiotrichales 72273|Thiotrichales CO Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps dsbD - 1.8.1.8 ko:K04084 - - - - ko00000,ko01000,ko03110 5.A.1.1 - - DsbC,DsbD,Thioredoxin,Thioredoxin_7 k59_222972_1 1379270.AUXF01000001_gene1915 1.16e-66 220.0 COG1502@1|root,COG1502@2|Bacteria 2|Bacteria I Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol CP_0318 - - ko:K06131,ko:K06132 ko00564,ko01100,map00564,map01100 - R07390,R11062 RC00017 ko00000,ko00001,ko01000 - - - PLDc_2 k59_1747494_1 1122137.AQXF01000003_gene2072 1.27e-162 479.0 COG0568@1|root,COG0568@2|Bacteria,1MVNJ@1224|Proteobacteria,2TS6C@28211|Alphaproteobacteria 28211|Alphaproteobacteria K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth rpoD - - ko:K03086 - - - - ko00000,ko03021 - - - Sigma70_ner,Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4 k59_222979_1 366394.Smed_0067 1.26e-90 284.0 COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,2TST2@28211|Alphaproteobacteria,4BA0V@82115|Rhizobiaceae 28211|Alphaproteobacteria L Belongs to the DEAD box helicase family deaD - 3.6.4.13 ko:K05592 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03009,ko03019 - - - DEAD,DbpA,Helicase_C k59_55538_1 1229909.NSED_08165 3.96e-156 459.0 COG1048@1|root,arCOG01697@2157|Archaea,41SE6@651137|Thaumarchaeota 651137|Thaumarchaeota C aconitate hydratase - - 4.2.1.3 ko:K01681 ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00173,M00740 R01324,R01325,R01900 RC00497,RC00498,RC00618 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase,Aconitase_C k59_672840_1 1267535.KB906767_gene3861 3.63e-12 65.5 COG4103@1|root,COG4103@2|Bacteria 2|Bacteria T Tellurite resistance protein TerB - - - - - - - - - - - - TerB k59_672840_2 1333998.M2A_2401 3.05e-36 133.0 COG1960@1|root,COG1960@2|Bacteria,1MVJC@1224|Proteobacteria,2TQRA@28211|Alphaproteobacteria,4BP67@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria I Acyl-CoA dehydrogenase, N-terminal domain - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_1124621_1 1415778.JQMM01000001_gene593 1.28e-95 287.0 COG1845@1|root,COG1845@2|Bacteria,1MUCK@1224|Proteobacteria,1RN9D@1236|Gammaproteobacteria,1J4UE@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C COG1845 Heme copper-type cytochrome quinol oxidase, subunit 3 coxC - 1.9.3.1 ko:K02276 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.4,3.D.4.6 - - COX3 k59_281064_1 330214.NIDE2727 4.1e-58 195.0 COG1249@1|root,COG1249@2|Bacteria,3J0IM@40117|Nitrospirae 40117|Nitrospirae C Evidence 2a Function of homologous gene experimentally demonstrated in an other organism - - 1.8.1.4 ko:K00382 ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00036,M00307,M00532 R00209,R01221,R01698,R03815,R07618,R08549 RC00004,RC00022,RC00583,RC02742,RC02833,RC02834 br01601,ko00000,ko00001,ko00002,ko01000,ko04147 - - - Pyr_redox_2,Pyr_redox_dim k59_111468_1 1396858.Q666_12905 8.48e-37 139.0 COG0495@1|root,COG0495@2|Bacteria,1MV47@1224|Proteobacteria,1RP14@1236|Gammaproteobacteria,464DK@72275|Alteromonadaceae 1236|Gammaproteobacteria J Belongs to the class-I aminoacyl-tRNA synthetase family leuS GO:0003674,GO:0003824,GO:0004812,GO:0004823,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006429,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.4 ko:K01869 ko00970,map00970 M00359,M00360 R03657 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - iECOK1_1307.ECOK1_0652,iECS88_1305.ECS88_0684,iNRG857_1313.NRG857_02925,iPC815.YPO2610 Anticodon_1,tRNA-synt_1,tRNA-synt_1_2 k59_1635296_1 1004149.AFOE01000043_gene1725 1.38e-47 161.0 COG3717@1|root,COG3717@2|Bacteria,4NDUV@976|Bacteroidetes,1HY64@117743|Flavobacteriia 976|Bacteroidetes G Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate kduI - 5.3.1.17 ko:K01815 ko00040,map00040 - R04383 RC00541 ko00000,ko00001,ko01000 - - - KduI k59_734026_2 330214.NIDE3273 4.96e-25 96.3 COG1826@1|root,COG1826@2|Bacteria,3J1A4@40117|Nitrospirae 40117|Nitrospirae U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system - - - ko:K03116 ko03060,ko03070,map03060,map03070 M00336 - - ko00000,ko00001,ko00002,ko02044 2.A.64 - - MttA_Hcf106 k59_1071781_1 1123037.AUDE01000014_gene459 1.1e-14 72.4 COG0253@1|root,COG0253@2|Bacteria,4NF26@976|Bacteroidetes,1HY3U@117743|Flavobacteriia 976|Bacteroidetes E Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan dapF GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008837,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016853,GO:0016854,GO:0016855,GO:0019752,GO:0036361,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0047661,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.1.1.7 ko:K01778 ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00527 R02735 RC00302 ko00000,ko00001,ko00002,ko01000 - - - DAP_epimerase k59_1071781_2 886377.Murru_0006 4.74e-53 172.0 COG1670@1|root,COG1670@2|Bacteria,4NQ8K@976|Bacteroidetes,1I27H@117743|Flavobacteriia 976|Bacteroidetes J acetyltransferase speG - 2.3.1.57 ko:K00657 ko00330,ko01100,ko04216,map00330,map01100,map04216 M00135 R01154 RC00004,RC00096 ko00000,ko00001,ko00002,ko01000 - - - Acetyltransf_3 k59_1635299_1 362976.HQ_1425A 3.11e-78 249.0 COG0476@1|root,arCOG01676@2157|Archaea,2XTYV@28890|Euryarchaeota,23TM2@183963|Halobacteria 183963|Halobacteria H COG0476 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 ubaA - 2.7.7.80 ko:K21029 ko04122,map04122 - R07459 RC00043 ko00000,ko00001,ko01000 - - - ThiF k59_843897_1 331869.BAL199_15423 1.94e-114 344.0 COG0065@1|root,COG0065@2|Bacteria,1MVYR@1224|Proteobacteria,2TR6K@28211|Alphaproteobacteria,4BP5S@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate - - 4.2.1.33,4.2.1.35 ko:K01703 ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230 M00432,M00535 R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170 RC00497,RC00976,RC00977,RC01041,RC01046,RC03072 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase k59_1349940_1 926556.Echvi_1781 1.4e-19 94.0 COG0612@1|root,COG0612@2|Bacteria,4NEPT@976|Bacteroidetes,47M2G@768503|Cytophagia 976|Bacteroidetes S Peptidase M16 inactive domain - - - - - - - - - - - - Peptidase_M16,Peptidase_M16_C k59_1463710_1 1122137.AQXF01000002_gene185 6.41e-126 370.0 COG2262@1|root,COG2262@2|Bacteria,1MUA0@1224|Proteobacteria,2TUXJ@28211|Alphaproteobacteria 28211|Alphaproteobacteria S GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis hflX GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0003924,GO:0005488,GO:0005524,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006414,GO:0006417,GO:0006464,GO:0006468,GO:0006518,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006996,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010608,GO:0016043,GO:0016310,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0018105,GO:0018193,GO:0018209,GO:0019001,GO:0019222,GO:0019538,GO:0019843,GO:0022411,GO:0030554,GO:0031323,GO:0031326,GO:0032268,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032559,GO:0032561,GO:0032790,GO:0032984,GO:0032988,GO:0034248,GO:0034641,GO:0034645,GO:0035639,GO:0036094,GO:0036211,GO:0036289,GO:0043021,GO:0043022,GO:0043023,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043603,GO:0043604,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0046777,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051246,GO:0060255,GO:0065007,GO:0071704,GO:0071826,GO:0071840,GO:0072344,GO:0080090,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903008,GO:2000112 - ko:K03665 - - - - ko00000,ko03009 - - - GTP-bdg_M,GTP-bdg_N,MMR_HSR1 k59_165884_1 158500.BV97_00595 4.69e-134 390.0 COG2070@1|root,COG2070@2|Bacteria,1N52W@1224|Proteobacteria,2TV8B@28211|Alphaproteobacteria,2K00A@204457|Sphingomonadales 204457|Sphingomonadales S 2-nitropropane dioxygenase - - - - - - - - - - - - NMO k59_1747533_1 493475.GARC_2256 4.87e-38 131.0 2C85M@1|root,31482@2|Bacteria,1N2W2@1224|Proteobacteria,1S666@1236|Gammaproteobacteria,4680E@72275|Alteromonadaceae 1236|Gammaproteobacteria S Stress responsive A/B Barrel Domain - - - - - - - - - - - - Dabb,TAT_signal k59_1747533_2 1123229.AUBC01000007_gene19 1.89e-11 64.7 COG0176@1|root,COG0176@2|Bacteria,1MWQ8@1224|Proteobacteria,2TQJB@28211|Alphaproteobacteria,3JVUW@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria G Transaldolase/Fructose-6-phosphate aldolase tal GO:0003674,GO:0003824,GO:0004801,GO:0016740,GO:0016744 2.2.1.2 ko:K00616 ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007 R01827 RC00439,RC00604 ko00000,ko00001,ko00002,ko01000 - - - TAL_FSA k59_446735_1 519989.ECTPHS_09373 5.25e-40 158.0 COG4206@1|root,COG4206@2|Bacteria,1QTTF@1224|Proteobacteria,1T1GM@1236|Gammaproteobacteria 1236|Gammaproteobacteria H receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_501822_1 1216007.AOPM01000044_gene2844 9.09e-66 224.0 COG0612@1|root,COG0612@2|Bacteria,1MVST@1224|Proteobacteria,1RN05@1236|Gammaproteobacteria,2Q185@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria S Zn-dependent peptidases ptrA - - ko:K07263 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M16,Peptidase_M16_C k59_1239273_1 1229780.BN381_180029 6.76e-42 155.0 COG0628@1|root,COG0628@2|Bacteria,2GN4Y@201174|Actinobacteria 201174|Actinobacteria S permease - - - - - - - - - - - - AI-2E_transport k59_1747537_1 1190606.AJYG01000194_gene2779 4.72e-68 221.0 COG0141@1|root,COG0141@2|Bacteria,1MUUF@1224|Proteobacteria,1RPDZ@1236|Gammaproteobacteria,1XUEJ@135623|Vibrionales 135623|Vibrionales E Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine - - - - - - - - - - - - Histidinol_dh k59_740382_1 324925.Ppha_2858 5.38e-38 138.0 COG0491@1|root,COG0491@2|Bacteria 2|Bacteria GM Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid - - - - - - - - - - - - Lactamase_B k59_231530_1 172088.AUGA01000005_gene7832 4.67e-51 167.0 COG2318@1|root,COG2318@2|Bacteria,1RD3M@1224|Proteobacteria,2U8HG@28211|Alphaproteobacteria,3K0NF@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S DinB family dinB - - - - - - - - - - - DinB k59_965965_1 745310.G432_13460 3.24e-98 313.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2TQT0@28211|Alphaproteobacteria,2K02H@204457|Sphingomonadales 204457|Sphingomonadales V Efflux pump membrane transporter - - - ko:K18307 ko02024,map02024 M00644 - - ko00000,ko00001,ko00002,ko02000 2.A.6.2.20,2.A.6.2.32 - - ACR_tran k59_1078904_2 324602.Caur_1399 9.47e-28 116.0 COG0457@1|root,COG2114@1|root,COG3899@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG3899@2|Bacteria,2G699@200795|Chloroflexi,3764S@32061|Chloroflexia 32061|Chloroflexia T PFAM adenylyl cyclase class-3 4 guanylyl cyclase - - - - - - - - - - - - AAA_16,Guanylate_cyc,TPR_12,TPR_2 k59_344995_1 1122137.AQXF01000001_gene2960 4.54e-90 293.0 COG2887@1|root,COG3893@1|root,COG2887@2|Bacteria,COG3893@2|Bacteria,1MY2G@1224|Proteobacteria,2TS74@28211|Alphaproteobacteria 28211|Alphaproteobacteria L double-strand break repair protein AddB addB - 3.6.4.12 ko:K16899 - - - - ko00000,ko01000,ko03400 - - - PDDEXK_1 k59_401141_1 1122137.AQXF01000001_gene3005 1.35e-101 310.0 COG2200@1|root,COG2200@2|Bacteria,1N299@1224|Proteobacteria,2TT4R@28211|Alphaproteobacteria 28211|Alphaproteobacteria T EAL domain yfgF - - - - - - - - - - - EAL k59_1474683_1 67352.JODS01000024_gene3026 3.58e-45 159.0 COG2267@1|root,COG2267@2|Bacteria,2GIVB@201174|Actinobacteria 201174|Actinobacteria I Alpha beta hydrolase - - - - - - - - - - - - Hydrolase_4 k59_288515_1 1123237.Salmuc_03341 4.25e-26 104.0 COG1051@1|root,COG1051@2|Bacteria,1RKG8@1224|Proteobacteria,2UCMT@28211|Alphaproteobacteria 28211|Alphaproteobacteria F Including oxidative damage repair enzymes - - - - - - - - - - - - NUDIX k59_1023037_1 545276.KB898728_gene137 2.72e-69 217.0 COG0496@1|root,COG0496@2|Bacteria,1MVHE@1224|Proteobacteria,1RN36@1236|Gammaproteobacteria,1WW3F@135613|Chromatiales 135613|Chromatiales S Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates surE - 3.1.3.5 ko:K03787 ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110 - R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346 RC00017 ko00000,ko00001,ko01000 - - - SurE k59_1305210_1 436308.Nmar_1690 2.5e-163 467.0 COG1156@1|root,arCOG00865@2157|Archaea,41SPY@651137|Thaumarchaeota 651137|Thaumarchaeota C Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit atpB - - ko:K02118 ko00190,ko01100,map00190,map01100 M00159 - - ko00000,ko00001,ko00002 3.A.2.2,3.A.2.3 - - ATP-synt_ab,ATP-synt_ab_N k59_627133_1 1366050.N234_36435 8.29e-81 249.0 COG4974@1|root,COG4974@2|Bacteria,1MVAN@1224|Proteobacteria,2VNSH@28216|Betaproteobacteria,1KGQD@119060|Burkholderiaceae 28216|Betaproteobacteria L Phage integrase, N-terminal SAM-like domain - - - ko:K04763 - - - - ko00000,ko03036 - - - Phage_int_SAM_4,Phage_integrase k59_627133_2 1298867.AUES01000126_gene5138 2.09e-49 168.0 COG0517@1|root,COG0517@2|Bacteria,1MXI6@1224|Proteobacteria,2TS6X@28211|Alphaproteobacteria,3JWIG@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S Putative transposase - - - - - - - - - - - - Y2_Tnp,Zn_Tnp_IS91 k59_1305212_1 1229909.NSED_07320 9.31e-164 472.0 COG3569@1|root,arCOG08649@2157|Archaea,41SDH@651137|Thaumarchaeota 651137|Thaumarchaeota L DNA Topoisomerase I (eukaryota) - - 5.99.1.2 ko:K03163 - - - - ko00000,ko01000,ko03032 - - - Topo_C_assoc,Topoisom_I,Topoisom_I_N k59_1474694_2 436308.Nmar_0059 2.39e-123 356.0 COG2875@1|root,arCOG00645@2157|Archaea,41SE7@651137|Thaumarchaeota 651137|Thaumarchaeota H Tetrapyrrole (Corrin/Porphyrin) Methylases - - 2.1.1.133,2.1.1.271 ko:K05936 ko00860,ko01100,map00860,map01100 - R05181,R05810 RC00003,RC01294,RC02049 ko00000,ko00001,ko01000 - - - TP_methylase k59_1135474_1 641526.ADIWIN_0960 4.11e-57 186.0 COG0457@1|root,COG0457@2|Bacteria,4NF5V@976|Bacteroidetes,1HYKU@117743|Flavobacteriia 976|Bacteroidetes T tetratricopeptide repeat batE - - - - - - - - - - - SH3_3,SH3_4,TPR_1,TPR_11,TPR_16,TPR_2 k59_288530_1 1229909.NSED_09915 2e-70 216.0 COG2242@1|root,arCOG00977@2157|Archaea,41SID@651137|Thaumarchaeota 651137|Thaumarchaeota J Catalyzes the methylation of C-15 in cobalt-precorrin-6B followed by the decarboxylation of C-12 to form cobalt-precorrin- 7 cbiT - 2.1.1.196 ko:K02191 ko00860,map00860 - R05813,R07774 RC00003,RC02052,RC02054 ko00000,ko00001,ko01000 - - - Methyltransf_31 k59_683483_1 247634.GPB2148_723 2.53e-106 329.0 COG0188@1|root,COG0188@2|Bacteria,1MURI@1224|Proteobacteria,1RMTC@1236|Gammaproteobacteria,1J4FT@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule parC GO:0000819,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006265,GO:0006276,GO:0006725,GO:0006807,GO:0006996,GO:0007049,GO:0007059,GO:0007062,GO:0008150,GO:0008152,GO:0009330,GO:0009987,GO:0016020,GO:0016043,GO:0019897,GO:0019898,GO:0022402,GO:0030541,GO:0032991,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0046483,GO:0051276,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:0098813,GO:1901360,GO:1901363 - ko:K02621 - - - - ko00000,ko01000,ko02048,ko03032,ko03036 - - - DNA_gyraseA_C,DNA_topoisoIV k59_1135486_1 1121413.JMKT01000009_gene2056 4.66e-47 166.0 COG0517@1|root,COG1994@1|root,COG0517@2|Bacteria,COG1994@2|Bacteria,1MY9R@1224|Proteobacteria,42R1V@68525|delta/epsilon subdivisions,2WN7S@28221|Deltaproteobacteria,2MEHG@213115|Desulfovibrionales 28221|Deltaproteobacteria S Belongs to the peptidase M50B family - - - - - - - - - - - - CBS,Peptidase_M50,Peptidase_M50B k59_1023053_1 1122137.AQXF01000001_gene2891 5.58e-36 134.0 COG3608@1|root,COG3608@2|Bacteria,1MUAA@1224|Proteobacteria,2TRVI@28211|Alphaproteobacteria 28211|Alphaproteobacteria S succinylglutamate desuccinylase - - - ko:K06987 - - - - ko00000 - - - AstE_AspA k59_1023053_2 1122137.AQXF01000001_gene2892 3.91e-26 101.0 COG1230@1|root,COG1230@2|Bacteria,1MUSS@1224|Proteobacteria,2TQWX@28211|Alphaproteobacteria 28211|Alphaproteobacteria P Co Zn Cd efflux system component - - - - - - - - - - - - Cation_efflux k59_853359_1 1049564.TevJSym_ao00260 5.23e-17 86.3 COG1452@1|root,COG1452@2|Bacteria,1MUJC@1224|Proteobacteria,1RQEX@1236|Gammaproteobacteria,1J4G3@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane lptD GO:0005575,GO:0005623,GO:0006810,GO:0006869,GO:0008150,GO:0009279,GO:0009636,GO:0009987,GO:0010876,GO:0015920,GO:0016020,GO:0016043,GO:0019867,GO:0022607,GO:0030312,GO:0030313,GO:0031975,GO:0033036,GO:0042221,GO:0043163,GO:0043165,GO:0044085,GO:0044091,GO:0044462,GO:0044464,GO:0045229,GO:0050896,GO:0051179,GO:0051234,GO:0061024,GO:0071702,GO:0071709,GO:0071840,GO:0071944,GO:1901264 - ko:K04744 - - - - ko00000,ko02000 1.B.42.1 - iG2583_1286.G2583_0058 OstA,OstA_C k59_1531142_1 1122137.AQXF01000002_gene76 1.99e-135 391.0 COG0416@1|root,COG0416@2|Bacteria,1MVM3@1224|Proteobacteria,2TR53@28211|Alphaproteobacteria 28211|Alphaproteobacteria I Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA plsX - 2.3.1.15 ko:K03621 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R00851,R09380 RC00004,RC00039,RC00041 ko00000,ko00001,ko00002,ko01000,ko01004 - - - FA_synthesis k59_1700450_1 1122137.AQXF01000001_gene3234 2.19e-95 283.0 COG1192@1|root,COG1192@2|Bacteria,1MV43@1224|Proteobacteria,2TSWH@28211|Alphaproteobacteria 28211|Alphaproteobacteria D Chromosome Partitioning parA - - ko:K03496 - - - - ko00000,ko03036,ko04812 - - - AAA_31 k59_1700450_2 1122137.AQXF01000001_gene3233 1.2e-08 56.2 COG1475@1|root,COG1475@2|Bacteria,1MW2E@1224|Proteobacteria,2TSTN@28211|Alphaproteobacteria 28211|Alphaproteobacteria K Belongs to the ParB family parB - - ko:K03497 - - - - ko00000,ko03000,ko03036,ko04812 - - - ParBc k59_401179_1 1266925.JHVX01000019_gene1787 7.57e-99 319.0 COG0086@1|root,COG0086@2|Bacteria,1MU3M@1224|Proteobacteria,2VIF3@28216|Betaproteobacteria,371R1@32003|Nitrosomonadales 28216|Betaproteobacteria K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoC - 2.7.7.6 ko:K03046 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5 k59_796870_1 1121912.AUHD01000003_gene3074 4.22e-97 295.0 COG0477@1|root,COG2814@2|Bacteria,4NFRE@976|Bacteroidetes,1HXWF@117743|Flavobacteriia 976|Bacteroidetes EGP MFS transporter - - - - - - - - - - - - MFS_1,MFS_3 k59_457745_1 522306.CAP2UW1_1014 3.01e-83 260.0 COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,2VH16@28216|Betaproteobacteria,1KQIU@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria F DEAD-box RNA helicase involved in ribosome assembly. Has RNA-dependent ATPase activity and unwinds double-stranded RNA rhlE GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008026,GO:0008104,GO:0008150,GO:0008186,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032991,GO:0033036,GO:0035770,GO:0036464,GO:0042623,GO:0043186,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044424,GO:0044444,GO:0044464,GO:0045495,GO:0051179,GO:0060293,GO:0070035,GO:0140098,GO:1990904 3.6.4.13 ko:K11927 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - DEAD,Helicase_C k59_683495_1 1499689.CCNN01000007_gene2468 1.58e-21 92.4 COG1670@1|root,COG1670@2|Bacteria,1V1G8@1239|Firmicutes,24G73@186801|Clostridia,36FYE@31979|Clostridiaceae 186801|Clostridia J Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_3 k59_5887_1 323848.Nmul_A0564 2.2e-25 104.0 COG5473@1|root,COG5473@2|Bacteria,1N9UJ@1224|Proteobacteria,2VNM5@28216|Betaproteobacteria,371X2@32003|Nitrosomonadales 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_1305248_2 436308.Nmar_0045 2.68e-66 204.0 arCOG10514@1|root,arCOG10514@2157|Archaea,41STR@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1305248_3 1229909.NSED_09845 4.92e-106 313.0 COG0300@1|root,arCOG01263@2157|Archaea,41SXQ@651137|Thaumarchaeota 651137|Thaumarchaeota S Belongs to the short-chain dehydrogenases reductases (SDR) family - - - ko:K07124 - - - - ko00000 - - - adh_short k59_231576_1 309807.SRU_0660 5.92e-29 117.0 COG1640@1|root,COG1640@2|Bacteria,4NF7Z@976|Bacteroidetes,1FIU5@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes G 4-alpha-glucanotransferase malQ - 2.4.1.25 ko:K00705 ko00500,ko01100,map00500,map01100 - R05196 RC00049 ko00000,ko00001,ko01000 - GH77 - Alpha-amylase,Glyco_hydro_77 k59_683498_1 436308.Nmar_1072 7.04e-126 373.0 COG0028@1|root,arCOG01998@2157|Archaea,41S63@651137|Thaumarchaeota 651137|Thaumarchaeota E TIGRFAM acetolactate synthase, large subunit, biosynthetic type - - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_1700458_1 1131451.O1K_20582 1.99e-83 267.0 COG3511@1|root,COG3511@2|Bacteria,1MWVP@1224|Proteobacteria,1RRZZ@1236|Gammaproteobacteria,1XC3B@135614|Xanthomonadales 135614|Xanthomonadales M phospholipase C - - 3.1.4.3 ko:K01114 ko00562,ko00564,ko00565,ko01100,ko01110,ko02024,ko04919,map00562,map00564,map00565,map01100,map01110,map02024,map04919 - R01312,R02027,R02052,R03332,R07381 RC00017,RC00425 ko00000,ko00001,ko01000,ko02042 - - - DUF756,Phosphoesterase k59_1192239_1 436308.Nmar_0479 1.66e-101 305.0 COG0226@1|root,arCOG00213@2157|Archaea,41SXU@651137|Thaumarchaeota 651137|Thaumarchaeota P TIGRFAM phosphate ABC transporter - - - ko:K02040 ko02010,ko02020,ko05152,map02010,map02020,map05152 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - PBP_like_2 k59_627172_1 617140.AJZE01000081_gene1713 2.42e-06 53.5 COG0454@1|root,COG1846@1|root,COG0456@2|Bacteria,COG1846@2|Bacteria 2|Bacteria K DNA-binding transcription factor activity - - - - - - - - - - - - Acetyltransf_10,MarR,MarR_2 k59_627172_2 644966.Tmar_1044 3.93e-18 85.9 COG1052@1|root,COG1052@2|Bacteria,1TPCX@1239|Firmicutes 1239|Firmicutes CH Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family - - 1.1.1.26,1.1.1.310,1.1.1.399,1.1.1.95 ko:K00015,ko:K00058,ko:K16843 ko00260,ko00270,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00260,map00270,map00630,map00680,map01100,map01110,map01120,map01130,map01200,map01230 M00020 R00717,R01388,R01513,R05693 RC00031,RC00042 ko00000,ko00001,ko00002,ko01000,ko04147 - - - 2-Hacid_dh,2-Hacid_dh_C k59_1417864_1 983920.Y88_3598 4.53e-87 277.0 COG3808@1|root,COG3808@2|Bacteria,1MUQ3@1224|Proteobacteria,2TR9G@28211|Alphaproteobacteria,2K0XA@204457|Sphingomonadales 204457|Sphingomonadales C Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force hppA - 3.6.1.1 ko:K15987 ko00190,map00190 - - - ko00000,ko00001,ko01000 3.A.10.1 - - H_PPase k59_1361654_1 377629.TERTU_3979 3.57e-51 171.0 COG1385@1|root,COG1385@2|Bacteria,1MXCU@1224|Proteobacteria,1RPBN@1236|Gammaproteobacteria,2PNET@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria J RNA methyltransferase rsmE GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016436,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070042,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.193 ko:K09761 - - - - ko00000,ko01000,ko03009 - - - Methyltrans_RNA k59_909535_1 1163617.SCD_n02503 1.86e-40 141.0 COG2823@1|root,COG2823@2|Bacteria,1MUZ2@1224|Proteobacteria,2VQIS@28216|Betaproteobacteria 28216|Betaproteobacteria S PFAM transport-associated - - - - - - - - - - - - BON k59_909535_2 1178482.BJB45_06075 2.58e-38 134.0 COG0279@1|root,COG0279@2|Bacteria,1NJ8X@1224|Proteobacteria,1RS1Y@1236|Gammaproteobacteria,1XI6S@135619|Oceanospirillales 135619|Oceanospirillales G Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate gmhA - 5.3.1.28 ko:K03271,ko:K12961 ko00540,ko01100,map00540,map01100 M00064 R05645,R09768,R09769 RC00434 ko00000,ko00001,ko00002,ko01000,ko01005,ko03036 - - - SIS_2 k59_1305274_2 999541.bgla_1g28110 1.52e-20 92.0 COG0389@1|root,COG0389@2|Bacteria,1MUUH@1224|Proteobacteria,2VJNS@28216|Betaproteobacteria,1K4SR@119060|Burkholderiaceae 28216|Betaproteobacteria L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII dinB GO:0000731,GO:0003674,GO:0003824,GO:0003887,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0006139,GO:0006259,GO:0006281,GO:0006301,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016604,GO:0016607,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0019985,GO:0031974,GO:0031981,GO:0032991,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0035770,GO:0036464,GO:0042276,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044422,GO:0044424,GO:0044428,GO:0044444,GO:0044446,GO:0044451,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0070013,GO:0071704,GO:0071897,GO:0090304,GO:0140097,GO:1901360,GO:1901362,GO:1901576,GO:1990904 2.7.7.7 ko:K02346,ko:K03502 - - - - ko00000,ko01000,ko03400 - - - IMS,IMS_C,IMS_HHH k59_1361674_1 1123518.ARWI01000001_gene928 1.28e-40 145.0 COG2890@1|root,COG2890@2|Bacteria,1MXCQ@1224|Proteobacteria,1RNGK@1236|Gammaproteobacteria,460FJ@72273|Thiotrichales 72273|Thiotrichales J Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif prmC - 2.1.1.297 ko:K02493 - - R10806 RC00003,RC03279 ko00000,ko01000,ko03012 - - - MTS,Methyltransf_31 k59_627190_1 589873.EP13_07825 4.19e-14 70.9 COG3185@1|root,COG3185@2|Bacteria,1MUVZ@1224|Proteobacteria,1RN2Z@1236|Gammaproteobacteria,465EP@72275|Alteromonadaceae 1236|Gammaproteobacteria E 4-hydroxyphenylpyruvate dioxygenase hppD - 1.13.11.27 ko:K00457 ko00130,ko00350,ko00360,ko01100,map00130,map00350,map00360,map01100 M00044 R01372,R02521 RC00505,RC00738 ko00000,ko00001,ko00002,ko01000,ko04147 - - iJN746.PP_3433 Glyoxalase,Glyoxalase_5 k59_627190_2 247634.GPB2148_190 2.78e-76 231.0 COG0346@1|root,COG0346@2|Bacteria,1MWCV@1224|Proteobacteria,1S1HV@1236|Gammaproteobacteria 1236|Gammaproteobacteria E PFAM Glyoxalase bleomycin resistance protein dioxygenase - - - - - - - - - - - - Glyoxalase k59_457774_1 1122137.AQXF01000005_gene1358 7.95e-108 335.0 COG1629@1|root,COG1629@2|Bacteria,1MX4K@1224|Proteobacteria,2TV3K@28211|Alphaproteobacteria 28211|Alphaproteobacteria P COG1629 Outer membrane receptor proteins, mostly Fe transport - - - - - - - - - - - - Plug,TonB_dep_Rec k59_513952_1 545243.BAEV01000098_gene2546 3.21e-93 285.0 COG0473@1|root,COG0473@2|Bacteria,1TPEM@1239|Firmicutes,24A63@186801|Clostridia,36E5F@31979|Clostridiaceae 186801|Clostridia C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate icd - 1.1.1.41 ko:K00030 ko00020,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010 R00709 RC00114 br01601,ko00000,ko00001,ko00002,ko01000 - - - Iso_dh k59_513952_2 1536773.R70331_00540 4.83e-40 145.0 COG2094@1|root,COG2094@2|Bacteria,1V1E6@1239|Firmicutes,4HJ10@91061|Bacilli,274ME@186822|Paenibacillaceae 91061|Bacilli L Responsible for recognizing base lesions in the genome and initiating base excision DNA repair - GO:0003674,GO:0003824,GO:0003905,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360 3.2.2.21 ko:K03652 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - Pur_DNA_glyco k59_966052_1 391625.PPSIR1_11968 5.1e-51 171.0 COG0300@1|root,COG0300@2|Bacteria,1QX5R@1224|Proteobacteria,43433@68525|delta/epsilon subdivisions,2X4ZK@28221|Deltaproteobacteria,2YZWA@29|Myxococcales 28221|Deltaproteobacteria S Enoyl-(Acyl carrier protein) reductase - - - - - - - - - - - - adh_short_C2 k59_1192267_2 330214.NIDE1985 1.59e-22 98.6 COG0542@1|root,COG0542@2|Bacteria,3J0W0@40117|Nitrospirae 40117|Nitrospirae O C-terminal, D2-small domain, of ClpB protein - - - ko:K11907 ko02025,ko03070,map02025,map03070 M00334 - - ko00000,ko00001,ko00002,ko02044 3.A.23.1 - - AAA,AAA_2,ClpB_D2-small k59_683529_1 1096930.L284_15325 2.23e-42 143.0 COG1544@1|root,COG1544@2|Bacteria,1MZHW@1224|Proteobacteria,2TV3J@28211|Alphaproteobacteria,2K2CA@204457|Sphingomonadales 204457|Sphingomonadales J Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase hpf - - - - - - - - - - - Ribosom_S30AE_C,Ribosomal_S30AE k59_796924_1 330214.NIDE1304 5.17e-95 306.0 COG0086@1|root,COG0086@2|Bacteria,3J0BT@40117|Nitrospirae 40117|Nitrospirae K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoC GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234 2.7.7.6 ko:K03046 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5 k59_1305294_1 1121374.KB891585_gene1844 3.08e-99 297.0 COG0473@1|root,COG0473@2|Bacteria,1MUH4@1224|Proteobacteria,1RMZQ@1236|Gammaproteobacteria 1236|Gammaproteobacteria CE Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate leuB GO:0000287,GO:0003674,GO:0003824,GO:0003862,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0006950,GO:0007154,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0030145,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0034198,GO:0042594,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0055114,GO:0071496,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1990928 1.1.1.85 ko:K00052 ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230 M00432,M00535 R00994,R04426,R10052 RC00084,RC00417,RC03036 br01601,ko00000,ko00001,ko00002,ko01000 - - iECs_1301.ECs0077,iYL1228.KPN_00079,iZ_1308.Z0082 Iso_dh k59_627199_1 574966.KB898648_gene713 4.64e-75 239.0 COG0111@1|root,COG0111@2|Bacteria,1MU5Z@1224|Proteobacteria,1RPEY@1236|Gammaproteobacteria,1XHIW@135619|Oceanospirillales 135619|Oceanospirillales EH Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family serA - 1.1.1.399,1.1.1.95 ko:K00058 ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230 M00020 R01513 RC00031 ko00000,ko00001,ko00002,ko01000,ko04147 - - - 2-Hacid_dh,2-Hacid_dh_C,ACT k59_288618_2 1117314.PCIT_17535 5.58e-29 113.0 COG2227@1|root,COG2227@2|Bacteria,1PGF0@1224|Proteobacteria,1SFPC@1236|Gammaproteobacteria 1236|Gammaproteobacteria H Methyltransferase domain - - - - - - - - - - - - Methyltransf_23 k59_288620_1 477974.Daud_1106 1.7e-26 109.0 COG0438@1|root,COG0438@2|Bacteria,1TPTA@1239|Firmicutes,24ANI@186801|Clostridia,261CQ@186807|Peptococcaceae 186801|Clostridia M PFAM Glycosyl transferase, group 1 - - - - - - - - - - - - Glyco_transf_4,Glycos_transf_1 k59_62669_1 330214.NIDE3559 5.54e-46 150.0 COG0633@1|root,COG0633@2|Bacteria 2|Bacteria C Ferredoxin fdx GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006091,GO:0006790,GO:0008150,GO:0008152,GO:0009055,GO:0009987,GO:0016043,GO:0016226,GO:0016491,GO:0022607,GO:0022900,GO:0031163,GO:0044085,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0051186,GO:0051536,GO:0051537,GO:0051540,GO:0055114,GO:0071840 - ko:K04755 - - - - ko00000 - - - Fer2 k59_345121_2 688245.CtCNB1_1225 6.89e-11 65.9 COG2267@1|root,COG2267@2|Bacteria,1NTH9@1224|Proteobacteria,2VKCZ@28216|Betaproteobacteria,4AC2B@80864|Comamonadaceae 28216|Betaproteobacteria I Alpha beta hydrolase - - - - - - - - - - - - Abhydrolase_1,Abhydrolase_6 k59_457790_1 436308.Nmar_0040 4.81e-123 354.0 COG0603@1|root,arCOG00039@2157|Archaea,41SGR@651137|Thaumarchaeota 651137|Thaumarchaeota H Queuosine biosynthesis protein QueC - - 6.3.4.20 ko:K06920 ko00790,ko01100,map00790,map01100 - R09978 RC00959 ko00000,ko00001,ko01000,ko03016 - - - QueC k59_457790_2 1229909.NSED_09830 3.02e-107 317.0 COG0083@1|root,arCOG01027@2157|Archaea,41S89@651137|Thaumarchaeota 651137|Thaumarchaeota E Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate thrB - 2.7.1.39 ko:K00872 ko00260,ko01100,ko01110,ko01120,ko01230,map00260,map01100,map01110,map01120,map01230 M00018 R01771 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - GHMP_kinases_C,GHMP_kinases_N k59_1587383_2 421531.IX38_03435 6.2e-18 82.0 COG3637@1|root,COG3637@2|Bacteria,4NQQ0@976|Bacteroidetes,1I5M8@117743|Flavobacteriia,3ZS37@59732|Chryseobacterium 976|Bacteroidetes M Outer membrane protein beta-barrel domain - - - - - - - - - - - - OMP_b-brl,OMP_b-brl_2 k59_1474817_2 1499967.BAYZ01000001_gene5911 3.76e-82 252.0 COG2376@1|root,COG2376@2|Bacteria,2NQCP@2323|unclassified Bacteria 2|Bacteria G Dak1 domain dhaK GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016052,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019637,GO:0019751,GO:0033554,GO:0034308,GO:0042180,GO:0042182,GO:0042802,GO:0044237,GO:0044238,GO:0044248,GO:0044262,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0047324,GO:0050896,GO:0051716,GO:0061610,GO:0071704,GO:1901135,GO:1901575,GO:1901615 2.7.1.121,2.7.1.28,2.7.1.29,4.6.1.15 ko:K00863,ko:K05878 ko00051,ko00561,ko00680,ko01100,ko01120,ko01200,ko04622,map00051,map00561,map00680,map01100,map01120,map01200,map04622 M00344 R01011,R01012,R01059 RC00002,RC00015,RC00017 ko00000,ko00001,ko00002,ko01000 - - iEcHS_1320.EcHS_A1304,iUMNK88_1353.UMNK88_1515,iYL1228.KPN_03495 Dak1,Dak2 k59_1079005_1 1121374.KB891575_gene849 3.03e-102 306.0 COG0330@1|root,COG0330@2|Bacteria,1MV7R@1224|Proteobacteria,1RM8Z@1236|Gammaproteobacteria 1236|Gammaproteobacteria O HflC and HflK could regulate a protease hflC GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006508,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008233,GO:0009266,GO:0009408,GO:0009628,GO:0009897,GO:0009986,GO:0016020,GO:0016021,GO:0016787,GO:0019538,GO:0031224,GO:0031226,GO:0031233,GO:0032991,GO:0043086,GO:0043170,GO:0044092,GO:0044238,GO:0044425,GO:0044459,GO:0044464,GO:0050790,GO:0050896,GO:0065007,GO:0065009,GO:0071575,GO:0071704,GO:0071944,GO:0098552,GO:0098796,GO:0140096,GO:1901564 - ko:K04087 - M00742 - - ko00000,ko00002,ko01000 - - - Band_7 k59_119037_1 1051632.TPY_2822 8.96e-20 94.0 COG0624@1|root,COG0624@2|Bacteria,1TP2D@1239|Firmicutes 1239|Firmicutes E COG0624, acetylornithine deacetylase succinyl-diaminopimelate desuccinylase and related deacylases dapE - - - - - - - - - - - M20_dimer,Peptidase_M20 k59_627224_1 498848.TaqDRAFT_5234 2.51e-31 128.0 COG1361@1|root,COG3420@1|root,COG1361@2|Bacteria,COG3420@2|Bacteria,1WNFU@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus P Right handed beta helix region - - - - - - - - - - - - Beta_helix,DUF11 k59_1361711_2 999411.HMPREF1092_00421 2.58e-12 69.3 COG2199@1|root,COG3706@2|Bacteria,1VADD@1239|Firmicutes,25E7Q@186801|Clostridia,36UW7@31979|Clostridiaceae 186801|Clostridia T Diguanylate cyclase - - 2.7.7.65 ko:K21022 ko02025,map02025 - - - ko00000,ko00001,ko01000 - - - GAF,GAF_2,GAF_3,GGDEF,PAS_9 k59_64054_1 1123519.PSJM300_18070 0.000309 47.8 COG2863@1|root,COG2863@2|Bacteria,1N2NB@1224|Proteobacteria,1RZFP@1236|Gammaproteobacteria,1Z228@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria C COG2863 Cytochrome c553 cc4 - - - - - - - - - - - Cytochrom_C,Cytochrome_CBB3 k59_1588466_1 158500.BV97_05101 1.66e-26 105.0 COG2207@1|root,COG2207@2|Bacteria,1N6FY@1224|Proteobacteria,2UEU0@28211|Alphaproteobacteria,2K6FI@204457|Sphingomonadales 204457|Sphingomonadales K Helix-turn-helix domain - - - - - - - - - - - - HTH_18 k59_1588466_2 1144305.PMI02_04978 3.96e-162 458.0 COG0462@1|root,COG0462@2|Bacteria,1MW21@1224|Proteobacteria,2TR4Y@28211|Alphaproteobacteria,2K0MQ@204457|Sphingomonadales 204457|Sphingomonadales F Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) prs - 2.7.6.1 ko:K00948 ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230 M00005 R01049 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - Pribosyl_synth,Pribosyltran_N k59_798398_1 436308.Nmar_0207 1.31e-107 323.0 COG2368@1|root,arCOG02143@2157|Archaea,41SA0@651137|Thaumarchaeota 651137|Thaumarchaeota Q Vinylacetyl-CoA Delta-isomerase - - 4.2.1.120,5.3.3.3 ko:K14534 ko00650,ko00720,ko01100,ko01120,ko01200,map00650,map00720,map01100,map01120,map01200 M00374,M00375 R03031,R10782 RC01857,RC03277 ko00000,ko00001,ko00002,ko01000 - - - HpaB,HpaB_N k59_7315_1 176299.Atu2228 2.54e-19 93.6 COG3850@1|root,COG5001@1|root,COG3850@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2UQAK@28211|Alphaproteobacteria,4B728@82115|Rhizobiaceae 28211|Alphaproteobacteria T GGDEF domain - - - - - - - - - - - - EAL,GGDEF,HAMP,PAS,PAS_9 k59_1476147_2 1229909.NSED_04255 1.18e-81 243.0 COG1259@1|root,arCOG01759@2157|Archaea,41SQI@651137|Thaumarchaeota 651137|Thaumarchaeota S Bifunctional nuclease - - - ko:K08999 - - - - ko00000 - - - DNase-RNase k59_1362958_1 639030.JHVA01000001_gene2646 3.34e-29 122.0 COG0577@1|root,COG0577@2|Bacteria,3Y34I@57723|Acidobacteria 57723|Acidobacteria V MacB-like periplasmic core domain - - - - - - - - - - - - FtsX,MacB_PCD k59_741556_1 349102.Rsph17025_2592 1.09e-67 213.0 COG0266@1|root,COG0266@2|Bacteria,1MVM5@1224|Proteobacteria,2TS4C@28211|Alphaproteobacteria,1FAVS@1060|Rhodobacter 28211|Alphaproteobacteria L Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates fpg - 3.2.2.23,4.2.99.18 ko:K10563 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - Fapy_DNA_glyco,H2TH,zf-FPG_IleRS k59_741556_3 1122137.AQXF01000004_gene1605 1.32e-93 278.0 COG1024@1|root,COG1024@2|Bacteria,1MWZC@1224|Proteobacteria,2TRYS@28211|Alphaproteobacteria 28211|Alphaproteobacteria I Belongs to the enoyl-CoA hydratase isomerase family MA20_15895 - 4.2.1.17 ko:K01692,ko:K01715 ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01200,map01212 M00032,M00087 R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093 RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 - - - ECH_1 k59_798406_1 1122137.AQXF01000001_gene3233 9.09e-140 402.0 COG1475@1|root,COG1475@2|Bacteria,1MW2E@1224|Proteobacteria,2TSTN@28211|Alphaproteobacteria 28211|Alphaproteobacteria K Belongs to the ParB family parB - - ko:K03497 - - - - ko00000,ko03000,ko03036,ko04812 - - - ParBc k59_798406_2 1248916.ANFY01000003_gene1015 1.37e-18 83.6 COG0189@1|root,COG0189@2|Bacteria,1MVUA@1224|Proteobacteria,2TQNE@28211|Alphaproteobacteria,2K0JQ@204457|Sphingomonadales 204457|Sphingomonadales H Belongs to the prokaryotic GSH synthase family gshB - 6.3.2.3 ko:K01920 ko00270,ko00480,ko01100,map00270,map00480,map01100 M00118 R00497,R10994 RC00096,RC00141 ko00000,ko00001,ko00002,ko01000 - - - GSH-S_ATP,GSH-S_N k59_1362961_1 1415778.JQMM01000001_gene365 1.34e-93 291.0 COG5000@1|root,COG5000@2|Bacteria,1NU7E@1224|Proteobacteria,1S01Y@1236|Gammaproteobacteria,1J5XZ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T PAS fold - - - - - - - - - - - - HAMP,HATPase_c,HisKA,PAS,PAS_4 k59_346496_1 330214.NIDE1393 1.75e-165 480.0 COG0034@1|root,COG0034@2|Bacteria,3J0C5@40117|Nitrospirae 40117|Nitrospirae F Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine purF - 2.4.2.14 ko:K00764 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048 R01072 RC00010,RC02724,RC02752 ko00000,ko00001,ko00002,ko01000,ko01002 - - - GATase_7,Pribosyltran k59_1701631_1 1449076.JOOE01000002_gene744 7.34e-200 565.0 COG0404@1|root,COG0404@2|Bacteria,1MWZS@1224|Proteobacteria,2TSVD@28211|Alphaproteobacteria,2K1VS@204457|Sphingomonadales 204457|Sphingomonadales E Aminomethyltransferase folate-binding domain - - 2.1.1.341 ko:K15066 ko00627,ko01120,map00627,map01120 - R09271,R10136 RC00113,RC00392 ko00000,ko00001,ko01000 - - - GCV_T,GCV_T_C k59_176385_1 105559.Nwat_1620 1.04e-91 288.0 COG3975@1|root,COG3975@2|Bacteria,1MUHZ@1224|Proteobacteria,1RR50@1236|Gammaproteobacteria,1WWJW@135613|Chromatiales 135613|Chromatiales S protease with the C-terminal PDZ domain - - - - - - - - - - - - PDZ_2,Peptidase_M61 k59_749964_1 118166.JH976537_gene4053 4.15e-35 134.0 COG4242@1|root,COG4242@2|Bacteria,1G26G@1117|Cyanobacteria,1H921@1150|Oscillatoriales 1117|Cyanobacteria PQ Exopeptidase that catalyzes the hydrolytic cleavage of multi-L-arginyl-poly-L-aspartic acid (cyanophycin - - 3.4.15.6 ko:K13282 - - R09722 RC00064,RC00141 ko00000,ko01000,ko01002 - - - Peptidase_S51 k59_1089041_2 1123250.KB908394_gene1940 4.32e-10 62.8 COG0470@1|root,COG0470@2|Bacteria,1TRVS@1239|Firmicutes,4H3FX@909932|Negativicutes 909932|Negativicutes L DNA polymerase III holB - 2.7.7.7 ko:K02341 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_delta2,DNApol3-delta_C k59_693555_1 59538.XP_005960404.1 5.04e-21 91.3 COG1028@1|root,KOG1208@2759|Eukaryota,38CZD@33154|Opisthokonta,3BACQ@33208|Metazoa,3CSEJ@33213|Bilateria,481SB@7711|Chordata,495Q4@7742|Vertebrata,3J5ED@40674|Mammalia,4J08P@91561|Cetartiodactyla 33208|Metazoa Q retinol dehydrogenase 14 - - - ko:K11162,ko:K11168 - - - - ko00000,ko01000 - - - adh_short k59_693555_2 1160137.KB907307_gene1200 1.5e-43 153.0 COG1012@1|root,COG1012@2|Bacteria,2HHHD@201174|Actinobacteria,4FYR3@85025|Nocardiaceae 201174|Actinobacteria C Acyl-CoA reductase (LuxC) - - - - - - - - - - - - LuxC k59_15928_1 743720.Psefu_1383 2.17e-53 171.0 COG3631@1|root,COG3631@2|Bacteria,1NGQ1@1224|Proteobacteria 1224|Proteobacteria S SnoaL-like polyketide cyclase - - - - - - - - - - - - SnoaL,SnoaL_2 k59_73114_2 1266914.ATUK01000011_gene2432 1.55e-43 155.0 COG0489@1|root,COG0489@2|Bacteria,1MVI9@1224|Proteobacteria,1RNB0@1236|Gammaproteobacteria,1WWGG@135613|Chromatiales 135613|Chromatiales D AAA domain - - - - - - - - - - - - AAA_31,CbiA k59_1710510_1 1379270.AUXF01000002_gene1577 3.3e-61 211.0 COG0515@1|root,COG5616@1|root,COG0515@2|Bacteria,COG5616@2|Bacteria,1ZUKV@142182|Gemmatimonadetes 142182|Gemmatimonadetes KLT Protein kinase domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase k59_807081_1 1096930.L284_05845 2.55e-114 331.0 COG0194@1|root,COG0194@2|Bacteria,1MW92@1224|Proteobacteria,2TSCQ@28211|Alphaproteobacteria,2K16A@204457|Sphingomonadales 204457|Sphingomonadales F Essential for recycling GMP and indirectly, cGMP gmk - 2.7.4.8 ko:K00942 ko00230,ko01100,map00230,map01100 M00050 R00332,R02090 RC00002 ko00000,ko00001,ko00002,ko01000 - - - Guanylate_kin k59_411062_1 1096930.L284_14700 1.58e-119 351.0 COG3853@1|root,COG3853@2|Bacteria,1MY18@1224|Proteobacteria,2TU4T@28211|Alphaproteobacteria,2K07G@204457|Sphingomonadales 204457|Sphingomonadales P Toxic anion resistance - - - - - - - - - - - - TelA k59_919521_2 1232437.KL661976_gene4970 8.18e-06 50.1 COG3829@1|root,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria,42M88@68525|delta/epsilon subdivisions,2WIZI@28221|Deltaproteobacteria,2MJ2S@213118|Desulfobacterales 28221|Deltaproteobacteria T PFAM sigma-54 factor interaction domain-containing protein - - - - - - - - - - - - HTH_8,PAS_9,Sigma54_activat k59_580603_1 1122137.AQXF01000001_gene2761 0.000161 43.9 COG2866@1|root,COG2866@2|Bacteria,1N9W9@1224|Proteobacteria,2U2SA@28211|Alphaproteobacteria 28211|Alphaproteobacteria E carboxypeptidase - - - - - - - - - - - - Peptidase_M14 k59_580603_2 1117958.PE143B_0107960 5.2e-31 128.0 COG2199@1|root,COG3706@2|Bacteria,1RC1J@1224|Proteobacteria,1S2CD@1236|Gammaproteobacteria 1236|Gammaproteobacteria T Diguanylate cyclase - - - - - - - - - - - - CHASE,GGDEF,PAS,PAS_3,PAS_9 k59_1427723_1 279238.Saro_0177 2.58e-92 278.0 COG0119@1|root,COG0119@2|Bacteria,1MUMX@1224|Proteobacteria,2TT1R@28211|Alphaproteobacteria,2K1YI@204457|Sphingomonadales 204457|Sphingomonadales E HMGL-like - - 4.1.3.4 ko:K01640 ko00072,ko00280,ko00281,ko00650,ko01100,ko04146,map00072,map00280,map00281,map00650,map01100,map04146 M00036,M00088 R01360,R08090 RC00502,RC00503,RC01118,RC01946 ko00000,ko00001,ko00002,ko01000 - - - HMGL-like k59_411084_1 1250006.JHZZ01000001_gene39 1.13e-54 193.0 COG3537@1|root,COG3537@2|Bacteria,4NDYB@976|Bacteroidetes,1HWR3@117743|Flavobacteriia,3VW0S@52959|Polaribacter 976|Bacteroidetes G Glycosyl hydrolase family 92 - - - - - - - - - - - - CHB_HEX_C_1,F5_F8_type_C,Fn3_assoc,Glyco_hydro_92 k59_749990_1 1078020.KEK_11503 1.48e-68 229.0 COG3386@1|root,COG3386@2|Bacteria,2GNM1@201174|Actinobacteria,233K1@1762|Mycobacteriaceae 201174|Actinobacteria G SMP-30 Gluconolaconase - - - - - - - - - - - - SGL k59_637050_1 498211.CJA_1760 1.61e-67 223.0 COG0326@1|root,COG0326@2|Bacteria,1MUUE@1224|Proteobacteria,1RNWD@1236|Gammaproteobacteria,1FGXV@10|Cellvibrio 1236|Gammaproteobacteria O Hsp90 protein htpG GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006950,GO:0006974,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0033554,GO:0042623,GO:0042802,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716 - ko:K04079 ko04141,ko04151,ko04217,ko04612,ko04621,ko04626,ko04657,ko04659,ko04914,ko04915,ko05200,ko05215,ko05418,map04141,map04151,map04217,map04612,map04621,map04626,map04657,map04659,map04914,map04915,map05200,map05215,map05418 - - - ko00000,ko00001,ko01009,ko03029,ko03051,ko03110,ko04131,ko04147 - - - HATPase_c,HATPase_c_3,HSP90 k59_1485329_1 886293.Sinac_1559 2.82e-67 221.0 COG1132@1|root,COG1132@2|Bacteria,2IYCU@203682|Planctomycetes 2|Bacteria V ABC-type multidrug transport system ATPase and permease - - - ko:K06147 - - - - ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_tran k59_1710536_1 1415779.JOMH01000001_gene2609 4.99e-23 90.5 COG0864@1|root,COG0864@2|Bacteria,1NQ56@1224|Proteobacteria,1SH84@1236|Gammaproteobacteria,1XBEW@135614|Xanthomonadales 135614|Xanthomonadales K Transcriptional regulator - - - - - - - - - - - - - k59_1710536_2 96561.Dole_1385 8.29e-43 141.0 COG3093@1|root,COG3093@2|Bacteria,1N76J@1224|Proteobacteria,42SN8@68525|delta/epsilon subdivisions,2WPDK@28221|Deltaproteobacteria,2MQ2C@213118|Desulfobacterales 28221|Deltaproteobacteria K Cro/C1-type HTH DNA-binding domain - - - ko:K21498 - - - - ko00000,ko02048 - - - HTH_3 k59_693587_1 1122137.AQXF01000002_gene364 7.2e-70 221.0 COG0584@1|root,COG0584@2|Bacteria,1MVWZ@1224|Proteobacteria,2TV4M@28211|Alphaproteobacteria 28211|Alphaproteobacteria C glycerophosphoryl diester phosphodiesterase glpQ - 3.1.4.46 ko:K01126 ko00564,map00564 - R01030,R01470 RC00017,RC00425 ko00000,ko00001,ko01000 - - - GDPD k59_864055_1 497964.CfE428DRAFT_5656 1.25e-28 115.0 COG0204@1|root,COG0318@1|root,COG0204@2|Bacteria,COG0318@2|Bacteria,46SG3@74201|Verrucomicrobia 74201|Verrucomicrobia IQ PFAM AMP-dependent synthetase and ligase caiC - 2.3.1.40,6.2.1.20 ko:K05939 ko00071,ko00564,map00071,map00564 - R01406,R04864 RC00014,RC00039,RC00041 ko00000,ko00001,ko01000 - - - AMP-binding,AMP-binding_C,Acyltransferase k59_750005_1 215803.DB30_2443 0.000135 49.7 COG2885@1|root,COG4932@1|root,COG2885@2|Bacteria,COG4932@2|Bacteria,1QUEG@1224|Proteobacteria 1224|Proteobacteria M Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane - - - - - - - - - - - - SdrD_B k59_864056_1 720554.Clocl_2665 1.47e-75 254.0 COG0318@1|root,COG0318@2|Bacteria,1UZQF@1239|Firmicutes,25ECZ@186801|Clostridia,3WJ0C@541000|Ruminococcaceae 186801|Clostridia IQ Phosphopantetheine attachment site - - - - - - - - - - - - AMP-binding,AMP-binding_C,KR,PP-binding k59_693595_1 1280950.HJO_15099 1.02e-39 142.0 COG1073@1|root,COG1073@2|Bacteria,1NX52@1224|Proteobacteria,2TSJM@28211|Alphaproteobacteria 28211|Alphaproteobacteria I Alpha beta hydrolase - - - - - - - - - - - - Abhydrolase_6 k59_1597592_1 1027273.GZ77_16820 2.58e-21 93.6 COG1589@1|root,COG1589@2|Bacteria,1N0T7@1224|Proteobacteria,1S9FJ@1236|Gammaproteobacteria,1XJJQ@135619|Oceanospirillales 135619|Oceanospirillales D Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly ftsQ - - ko:K03589 ko04112,map04112 - - - ko00000,ko00001,ko03036 - - - FtsQ,POTRA_1 k59_975336_1 1122137.AQXF01000001_gene2992 5.36e-106 311.0 COG1842@1|root,COG1842@2|Bacteria,1NC7S@1224|Proteobacteria,2U6CN@28211|Alphaproteobacteria 28211|Alphaproteobacteria KT Phage shock protein pspA - - ko:K03969 - - - - ko00000 - - - PspA_IM30 k59_73146_1 13690.CP98_01840 4.84e-31 125.0 COG1629@1|root,COG4771@2|Bacteria,1NQGX@1224|Proteobacteria,2UNXC@28211|Alphaproteobacteria,2K2D5@204457|Sphingomonadales 204457|Sphingomonadales P TonB-dependent Receptor Plug Domain - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_637059_1 69395.JQLZ01000004_gene805 6.31e-70 231.0 COG0475@1|root,COG1226@1|root,COG0475@2|Bacteria,COG1226@2|Bacteria,1MV34@1224|Proteobacteria,2TRC5@28211|Alphaproteobacteria,2KG19@204458|Caulobacterales 204458|Caulobacterales P Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family - - - ko:K11745,ko:K11747 - - - - ko00000,ko02000 2.A.37.1.1,2.A.37.1.2 - - Na_H_Exchanger,TrkA_N k59_298951_1 342610.Patl_2870 3.05e-14 78.2 COG0845@1|root,COG0845@2|Bacteria,1R4JA@1224|Proteobacteria,1RPS5@1236|Gammaproteobacteria,2PZKY@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - - - - - - - - - - Biotin_lipoyl_2,HlyD_3 k59_975345_1 1279017.AQYJ01000021_gene2800 2.29e-62 202.0 COG0150@1|root,COG0150@2|Bacteria,1MURG@1224|Proteobacteria,1RNZZ@1236|Gammaproteobacteria,4644R@72275|Alteromonadaceae 1236|Gammaproteobacteria F Phosphoribosylformylglycinamidine cyclo-ligase purM GO:0003674,GO:0003824,GO:0004641,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016882,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.3.1 ko:K01933 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04208 RC01100 ko00000,ko00001,ko00002,ko01000 - - iECSF_1327.ECSF_2340 AIRS,AIRS_C k59_355560_1 1144305.PMI02_00256 1.93e-213 616.0 COG0060@1|root,COG0060@2|Bacteria,1MVBQ@1224|Proteobacteria,2TR3N@28211|Alphaproteobacteria,2K0GR@204457|Sphingomonadales 204457|Sphingomonadales J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) ileS - 6.1.1.5 ko:K01870 ko00970,map00970 M00359,M00360 R03656 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,tRNA-synt_1,zf-FPG_IleRS k59_750026_1 1150469.RSPPHO_00846 2.49e-10 60.5 COG3200@1|root,COG3200@2|Bacteria,1MUWF@1224|Proteobacteria,2TR0E@28211|Alphaproteobacteria,2JPFU@204441|Rhodospirillales 204441|Rhodospirillales E phospho-2-dehydro-3-deoxyheptonate aldolase aroF - 2.5.1.54 ko:K01626 ko00400,ko01100,ko01110,ko01130,ko01230,ko02024,map00400,map01100,map01110,map01130,map01230,map02024 M00022 R01826 RC00435 ko00000,ko00001,ko00002,ko01000 - - - DAHP_synth_2 k59_750026_2 1122137.AQXF01000002_gene52 1.43e-50 176.0 COG0171@1|root,COG0388@1|root,COG0171@2|Bacteria,COG0388@2|Bacteria,1MU9U@1224|Proteobacteria,2TRAU@28211|Alphaproteobacteria 28211|Alphaproteobacteria H Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source nadE GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008795,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016874,GO:0016879,GO:0016880,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.1.5,6.3.5.1 ko:K01916,ko:K01950 ko00760,ko01100,map00760,map01100 M00115 R00189,R00257 RC00010,RC00100 ko00000,ko00001,ko00002,ko01000 - - - CN_hydrolase,NAD_synthase k59_523582_1 1250232.JQNJ01000001_gene236 6.64e-48 173.0 COG3391@1|root,COG3391@2|Bacteria,4PKUJ@976|Bacteroidetes,1IJFM@117743|Flavobacteriia 976|Bacteroidetes S C-terminal domain of CHU protein family - - - - - - - - - - - - CHU_C,PKD k59_1710596_1 1137281.D778_00961 2.43e-95 288.0 COG3823@1|root,COG3823@2|Bacteria,4NF2M@976|Bacteroidetes,1HY29@117743|Flavobacteriia 976|Bacteroidetes O Glutamine cyclotransferase - - 2.3.2.5 ko:K00683 - - - - ko00000,ko01000 - - - Glu_cyclase_2 k59_298997_1 1005048.CFU_2015 2.36e-44 152.0 COG0664@1|root,COG0664@2|Bacteria,1R64V@1224|Proteobacteria,2VJXN@28216|Betaproteobacteria,472QZ@75682|Oxalobacteraceae 28216|Betaproteobacteria T Cyclic nucleotide-monophosphate binding domain - - - - - - - - - - - - cNMP_binding k59_1202386_1 702113.PP1Y_AT9009 7.51e-96 299.0 COG3590@1|root,COG3590@2|Bacteria,1MVNQ@1224|Proteobacteria,2TRU4@28211|Alphaproteobacteria,2K02W@204457|Sphingomonadales 204457|Sphingomonadales O peptidase M13 - - - ko:K07386 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M13,Peptidase_M13_N k59_1427772_1 1137281.D778_02613 1.46e-16 80.1 COG0438@1|root,COG0438@2|Bacteria,4NFWY@976|Bacteroidetes,1HZ7G@117743|Flavobacteriia 976|Bacteroidetes M Glycosyl transferases group 1 - - - ko:K16703 - - - - ko00000,ko01000,ko01003 - GT4 - Glyco_transf_4,Glycos_transf_1 k59_1427772_2 1122226.AUHX01000004_gene1786 9.1e-31 120.0 COG0438@1|root,COG0438@2|Bacteria,4NFEV@976|Bacteroidetes,1HYUE@117743|Flavobacteriia 976|Bacteroidetes M Glycosyl transferases group 1 - - - ko:K16703 - - - - ko00000,ko01000,ko01003 - GT4 - Glycos_transf_1 k59_15999_1 397287.C807_02081 1.52e-30 117.0 COG0253@1|root,COG0253@2|Bacteria,1TPMN@1239|Firmicutes,24AGY@186801|Clostridia,27IKY@186928|unclassified Lachnospiraceae 186801|Clostridia E Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan dapF - 5.1.1.7 ko:K01778 ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00527 R02735 RC00302 ko00000,ko00001,ko00002,ko01000 - - - DAP_epimerase k59_15999_2 1382230.ASAP_1284 1.25e-55 183.0 COG0329@1|root,COG0329@2|Bacteria,1MUCM@1224|Proteobacteria,2TR5W@28211|Alphaproteobacteria,2JPJS@204441|Rhodospirillales 204441|Rhodospirillales E Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) dapA - 4.3.3.7 ko:K01714 ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R10147 RC03062,RC03063 ko00000,ko00001,ko00002,ko01000 - - - DHDPS k59_1372229_1 1122137.AQXF01000004_gene1403 1.13e-56 183.0 COG0284@1|root,COG0284@2|Bacteria,1MW2C@1224|Proteobacteria,2TTB3@28211|Alphaproteobacteria 28211|Alphaproteobacteria F Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) pyrF GO:0003674,GO:0003824,GO:0004590,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006206,GO:0006207,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019856,GO:0034641,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046112,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.1.23 ko:K01591 ko00240,ko01100,map00240,map01100 M00051 R00965 RC00409 ko00000,ko00001,ko00002,ko01000 - - - OMPdecase k59_1372229_2 1331060.RLDS_09635 2.92e-21 94.4 COG3735@1|root,COG3735@2|Bacteria,1MVCW@1224|Proteobacteria,2U5RA@28211|Alphaproteobacteria,2JZWN@204457|Sphingomonadales 204457|Sphingomonadales S protein conserved in bacteria - - - ko:K09973 - - - - ko00000 - - - TraB k59_467452_1 301.JNHE01000004_gene1714 3.73e-32 131.0 COG1404@1|root,COG1404@2|Bacteria 2|Bacteria O Belongs to the peptidase S8 family - - 3.2.1.99 ko:K06113,ko:K12685 - - - - ko00000,ko01000,ko02000,ko02044 1.B.12.5.1,1.B.12.5.3 GH43 - Cu_amine_oxidN1,Peptidase_S8,PrcB_C,SLH k59_1033619_1 1122137.AQXF01000002_gene46 3.24e-170 485.0 COG3200@1|root,COG3200@2|Bacteria,1MUWF@1224|Proteobacteria,2TR0E@28211|Alphaproteobacteria 28211|Alphaproteobacteria E phospho-2-dehydro-3-deoxyheptonate aldolase aroF GO:0003674,GO:0003824,GO:0003849,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009507,GO:0009536,GO:0009611,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0019438,GO:0019752,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0050896,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.54 ko:K01626 ko00400,ko01100,ko01110,ko01130,ko01230,ko02024,map00400,map01100,map01110,map01130,map01230,map02024 M00022 R01826 RC00435 ko00000,ko00001,ko00002,ko01000 - - - DAHP_synth_2 k59_1315471_1 1110502.TMO_0633 2.64e-79 241.0 COG0410@1|root,COG0410@2|Bacteria,1MUR3@1224|Proteobacteria,2TSWQ@28211|Alphaproteobacteria,2JQ14@204441|Rhodospirillales 204441|Rhodospirillales E ABC transporter - - - ko:K01996 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - ABC_tran k59_1315471_2 1121479.AUBS01000001_gene3512 5.42e-32 118.0 COG0411@1|root,COG0411@2|Bacteria,1MX51@1224|Proteobacteria,2VEYC@28211|Alphaproteobacteria 28211|Alphaproteobacteria E branched-chain amino acid MA20_09940 - - ko:K01995 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - ABC_tran,BCA_ABC_TP_C k59_919578_1 1265313.HRUBRA_02678 2.52e-11 62.8 COG1185@1|root,COG1185@2|Bacteria,1MVB9@1224|Proteobacteria,1RNBF@1236|Gammaproteobacteria 1236|Gammaproteobacteria J Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction pnp GO:0000166,GO:0000175,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004518,GO:0004527,GO:0004532,GO:0004540,GO:0004654,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0008408,GO:0009056,GO:0009057,GO:0009266,GO:0009408,GO:0009628,GO:0009892,GO:0009987,GO:0010468,GO:0010605,GO:0010629,GO:0016070,GO:0016071,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016796,GO:0016896,GO:0017076,GO:0019001,GO:0019222,GO:0019439,GO:0030551,GO:0032553,GO:0032555,GO:0032561,GO:0034641,GO:0034655,GO:0035438,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0050896,GO:0060255,GO:0065007,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0097159,GO:0097367,GO:0140098,GO:1901265,GO:1901360,GO:1901361,GO:1901363,GO:1901575 2.7.7.8 ko:K00962 ko00230,ko00240,ko03018,map00230,map00240,map03018 M00394 R00437,R00438,R00439,R00440 RC02795 ko00000,ko00001,ko00002,ko01000,ko03016,ko03019 - - - KH_1,PNPase,RNase_PH,RNase_PH_C,S1 k59_919578_2 247634.GPB2148_947 7.37e-46 149.0 COG0184@1|root,COG0184@2|Bacteria,1MZ2W@1224|Proteobacteria,1S8U6@1236|Gammaproteobacteria,1J6I4@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome rpsO GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006378,GO:0006396,GO:0006397,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0016070,GO:0016071,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0031123,GO:0031124,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043631,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02956 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S15 k59_524741_1 13690.CP98_02794 6.99e-90 286.0 COG4772@1|root,COG4772@2|Bacteria,1MXJU@1224|Proteobacteria,2TRYT@28211|Alphaproteobacteria,2K004@204457|Sphingomonadales 204457|Sphingomonadales P receptor - - - - - - - - - - - - Plug,TonB_dep_Rec k59_865223_1 1137281.D778_01160 8.25e-82 249.0 COG4221@1|root,COG4221@2|Bacteria,4PKGY@976|Bacteroidetes,1IJ8P@117743|Flavobacteriia 976|Bacteroidetes S Enoyl-(Acyl carrier protein) reductase - - - - - - - - - - - - adh_short k59_1428986_1 316067.Geob_1250 5.4e-20 95.1 COG4251@1|root,COG4251@2|Bacteria,1NSQ1@1224|Proteobacteria,42YS1@68525|delta/epsilon subdivisions 1224|Proteobacteria T sensor histidine kinase - - - - - - - - - - - - CHASE,CHASE3,HATPase_c,HisKA,PAS_4,PAS_8,PAS_9,Response_reg k59_1090120_1 443144.GM21_0637 6.38e-39 134.0 COG2201@1|root,COG2201@2|Bacteria,1N7FN@1224|Proteobacteria,42V5Y@68525|delta/epsilon subdivisions,2WSBH@28221|Deltaproteobacteria,43V83@69541|Desulfuromonadales 28221|Deltaproteobacteria T cheY-homologous receiver domain cheY44H - - ko:K03413 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko02022,ko02035 - - - Response_reg k59_356718_1 436308.Nmar_0764 1.83e-104 320.0 COG0168@1|root,COG0517@1|root,arCOG00606@2157|Archaea,arCOG04145@2157|Archaea,41SZ8@651137|Thaumarchaeota 651137|Thaumarchaeota P CBS domain - - - ko:K03498 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - - CBS,TrkH k59_976411_1 1005048.CFU_4103 4.06e-77 243.0 COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,2VI01@28216|Betaproteobacteria,4737T@75682|Oxalobacteraceae 28216|Betaproteobacteria E PFAM Aminotransferase class I and II aspC - 2.6.1.1 ko:K00812 ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230 - R00355,R00694,R00734,R00896,R02433,R02619,R05052 RC00006 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_1_2 k59_1768280_1 1122137.AQXF01000003_gene2006 9.88e-07 49.7 COG2717@1|root,COG2717@2|Bacteria,1RDUP@1224|Proteobacteria,2U5HG@28211|Alphaproteobacteria 28211|Alphaproteobacteria C Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain msrQ - - ko:K17247 - - - - ko00000 - - - Ferric_reduct k59_1768280_2 1122137.AQXF01000003_gene2007 2.59e-70 215.0 COG2030@1|root,COG2030@2|Bacteria,1RIBV@1224|Proteobacteria,2U9QR@28211|Alphaproteobacteria 28211|Alphaproteobacteria I dehydratase MA20_05350 - - - - - - - - - - - MaoC_dehydratas k59_976435_1 713586.KB900536_gene2525 8.94e-61 198.0 COG2046@1|root,COG2046@2|Bacteria,1MUQB@1224|Proteobacteria,1RP4Q@1236|Gammaproteobacteria,1WWF2@135613|Chromatiales 135613|Chromatiales P Belongs to the sulfate adenylyltransferase family sat - 2.7.7.4 ko:K00958 ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130 M00176,M00596 R00529,R04929 RC02809,RC02889 ko00000,ko00001,ko00002,ko01000 - - - ATP-sulfurylase,PUA_2 k59_242723_1 366602.Caul_2355 3.23e-21 103.0 COG1629@1|root,COG1629@2|Bacteria,COG4771@2|Bacteria,1MU9K@1224|Proteobacteria,2TS4W@28211|Alphaproteobacteria,2KFP2@204458|Caulobacterales 204458|Caulobacterales P TonB-dependent receptor - - - - - - - - - - - - Plug,TonB_dep_Rec k59_74314_1 1298865.H978DRAFT_2113 5.28e-22 97.8 COG0544@1|root,COG0544@2|Bacteria,1MUJP@1224|Proteobacteria,1RNZE@1236|Gammaproteobacteria,46543@72275|Alteromonadaceae 1236|Gammaproteobacteria D Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase tig GO:0000413,GO:0003674,GO:0003755,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0006464,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0016853,GO:0016859,GO:0018193,GO:0018208,GO:0019538,GO:0036211,GO:0042802,GO:0043021,GO:0043022,GO:0043170,GO:0043335,GO:0043412,GO:0044183,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0050896,GO:0051083,GO:0061077,GO:0071704,GO:0140096,GO:1901564 - ko:K03545 - - - - ko00000 - - - FKBP_C,Trigger_C,Trigger_N k59_74314_2 998674.ATTE01000001_gene673 3.09e-23 93.6 COG0740@1|root,COG0740@2|Bacteria,1MV46@1224|Proteobacteria,1RNR6@1236|Gammaproteobacteria,45ZYA@72273|Thiotrichales 72273|Thiotrichales OU Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins clpP - 3.4.21.92 ko:K01358 ko04112,ko04212,map04112,map04212 - - - ko00000,ko00001,ko01000,ko01002 - - - CLP_protease k59_1316713_1 522306.CAP2UW1_3016 1.66e-103 312.0 COG1027@1|root,COG1027@2|Bacteria,1R9JY@1224|Proteobacteria,2W02M@28216|Betaproteobacteria,1KQIF@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria E Fumarase C C-terminus aspA - 4.3.1.1 ko:K01744 ko00250,ko01100,map00250,map01100 - R00490 RC00316,RC02799 ko00000,ko00001,ko01000 - - - FumaraseC_C,Lyase_1 k59_581920_1 555088.DealDRAFT_1279 5.63e-07 55.5 COG0745@1|root,COG0745@2|Bacteria,1TP9M@1239|Firmicutes,247TK@186801|Clostridia 186801|Clostridia KT response regulator receiver - - - - - - - - - - - - Response_reg,Trans_reg_C k59_242724_1 439497.RR11_2799 5.22e-103 331.0 COG0587@1|root,COG0587@2|Bacteria,1MUE4@1224|Proteobacteria,2TRUB@28211|Alphaproteobacteria,4NAKA@97050|Ruegeria 28211|Alphaproteobacteria L DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase dnaE2 GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0050896,GO:0051716,GO:0071496 2.7.7.7 ko:K02337,ko:K14162 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon k59_1259590_2 582744.Msip34_2820 1.72e-40 135.0 COG0636@1|root,32S3K@2|Bacteria,1N1NA@1224|Proteobacteria,2VTY0@28216|Betaproteobacteria,2KN1J@206350|Nitrosomonadales 206350|Nitrosomonadales C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation atpE - - ko:K02110 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt_C k59_1259590_3 751994.AGIG01000028_gene1913 0.000103 43.5 COG0356@1|root,COG0356@2|Bacteria,1MV87@1224|Proteobacteria,1RPHK@1236|Gammaproteobacteria,1J4Z2@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C it plays a direct role in the translocation of protons across the membrane atpB GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0005887,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016021,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0031224,GO:0031226,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0042777,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045263,GO:0045264,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - ko:K02108 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko03110 3.A.2.1 - iAPECO1_1312.APECO1_2725,iE2348C_1286.E2348C_4048,iEC042_1314.EC042_4125,iECABU_c1320.ECABU_c42230,iECED1_1282.ECED1_4428,iECIAI39_1322.ECIAI39_4342,iECNA114_1301.ECNA114_3887,iECOK1_1307.ECOK1_4187,iECP_1309.ECP_3937,iECS88_1305.ECS88_4160,iECSF_1327.ECSF_3586,iECUMN_1333.ECUMN_4268,iEcSMS35_1347.EcSMS35_4106,iLF82_1304.LF82_0192,iNRG857_1313.NRG857_18615,iUMN146_1321.UM146_18880,iUMNK88_1353.UMNK88_4550,iUTI89_1310.UTI89_C4293,ic_1306.c4666 ATP-synt_A k59_920828_1 1453501.JELR01000001_gene2897 4.77e-64 215.0 COG2010@1|root,COG2010@2|Bacteria,1MVYK@1224|Proteobacteria,1RQH2@1236|Gammaproteobacteria,465QC@72275|Alteromonadaceae 1236|Gammaproteobacteria C Cytochrome c - - - - - - - - - - - - - k59_412341_1 316407.85676543 1.57e-80 238.0 COG0640@1|root,COG0640@2|Bacteria,1MZT1@1224|Proteobacteria,1SAI5@1236|Gammaproteobacteria,3XPX9@561|Escherichia 1236|Gammaproteobacteria K Transcriptional repressor for the arsEFG operon. ArsE is a trans-acting regulatory protein which controls its own expression. The repressive effect of ArsE is alleviated by oxyions of III oxidation state of arsenic, antimony, and bismuth, as well as arsenate (As(V)) (By similarity) arsR GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031326,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0042221,GO:0043170,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0046685,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1903506,GO:2000112,GO:2001141 - ko:K03892 - - - - ko00000,ko03000 - - - HTH_5,LMWPc k59_1655943_1 2340.JV46_12450 9.14e-23 99.8 28KIX@1|root,2Z9Y0@2|Bacteria,1R427@1224|Proteobacteria,1RRGI@1236|Gammaproteobacteria 1236|Gammaproteobacteria S TIGRFAM Poly(R)-hydroxyalkanoic acid synthase, class III, PhaE subunit phaE GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0009058,GO:0016234,GO:0042618,GO:0042619,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464,GO:0070088,GO:0071704,GO:1901440,GO:1901441,GO:1901576 - - - - - - - - - - PHA_synth_III_E k59_74331_1 1541065.JRFE01000003_gene5430 9.3e-26 105.0 COG1309@1|root,COG1309@2|Bacteria,1G76B@1117|Cyanobacteria,3VJUR@52604|Pleurocapsales 1117|Cyanobacteria K Bacterial regulatory proteins, tetR family - - - - - - - - - - - - TetR_N k59_74331_2 940282.CADQ01000031_gene1922 3.48e-16 75.1 COG0694@1|root,COG0694@2|Bacteria,1MVQ1@1224|Proteobacteria,2TUD1@28211|Alphaproteobacteria,2JRTS@204441|Rhodospirillales 204441|Rhodospirillales O COG0694 Thioredoxin-like proteins and domains - - - - - - - - - - - - Nfu_N,NifU k59_1259596_1 452637.Oter_0795 9.27e-18 80.5 2E5WH@1|root,32RS6@2|Bacteria 2|Bacteria J 23S rRNA-intervening sequence protein - - - - - - - - - - - - 23S_rRNA_IVP k59_1259596_2 378806.STAUR_2865 8.43e-11 61.2 COG3666@1|root,COG3666@2|Bacteria,1N3QR@1224|Proteobacteria,42R6X@68525|delta/epsilon subdivisions,2WMY9@28221|Deltaproteobacteria 28221|Deltaproteobacteria L PFAM transposase, IS4 family protein - - - - - - - - - - - - DDE_Tnp_1,DDE_Tnp_1_6,DUF772 k59_1146651_1 1123279.ATUS01000001_gene2369 2.29e-96 291.0 COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,1RM93@1236|Gammaproteobacteria,1J4HU@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria I Belongs to the thiolase family thlA - 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N k59_1090174_2 566466.NOR53_2827 1.8e-57 179.0 COG0278@1|root,COG0278@2|Bacteria,1MZ4V@1224|Proteobacteria,1S640@1236|Gammaproteobacteria,1J9XK@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Glutaredoxin grxD - - ko:K07390 - - - - ko00000,ko03029,ko03110 - - - Glutaredoxin,Rhodanese k59_468815_3 1122137.AQXF01000005_gene1345 1.44e-26 104.0 2EN3P@1|root,33FRS@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_242743_1 913325.N799_07465 3.38e-12 68.2 COG2503@1|root,COG2503@2|Bacteria,1RB4N@1224|Proteobacteria,1SB1V@1236|Gammaproteobacteria,1X3JI@135614|Xanthomonadales 135614|Xanthomonadales S Acid phosphatase lppC - - - - - - - - - - - Acid_phosphat_B k59_1265751_2 1442599.JAAN01000023_gene1770 6.7e-37 134.0 COG1708@1|root,COG1708@2|Bacteria,1RCAH@1224|Proteobacteria,1S3KC@1236|Gammaproteobacteria,1X5GB@135614|Xanthomonadales 135614|Xanthomonadales K Nucleotidyltransferase domain - - - - - - - - - - - - MarR_2,NTP_transf_2 k59_982940_1 247634.GPB2148_3174 1.14e-24 100.0 2CJWX@1|root,32VVF@2|Bacteria,1RKS8@1224|Proteobacteria,1S8PY@1236|Gammaproteobacteria,1JA74@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Domain of unknown function (DUF3806) - - - - - - - - - - - - DUF3806 k59_757593_1 686340.Metal_0120 8.02e-54 187.0 COG0457@1|root,COG2304@1|root,COG0457@2|Bacteria,COG2304@2|Bacteria,1MW51@1224|Proteobacteria,1RMD3@1236|Gammaproteobacteria,1XEC7@135618|Methylococcales 135618|Methylococcales S von Willebrand factor, type A - - - ko:K07114 - - - - ko00000,ko02000 1.A.13.2.2,1.A.13.2.3 - - TPR_1,TPR_2,VWA_2 k59_1381397_1 713587.THITH_16285 3.65e-11 62.8 COG0412@1|root,COG0412@2|Bacteria,1RCWF@1224|Proteobacteria,1RY38@1236|Gammaproteobacteria,1WX5X@135613|Chromatiales 135613|Chromatiales Q PFAM Dienelactone hydrolase - - - - - - - - - - - - DLH k59_1381397_2 1280952.HJA_17380 5.07e-58 186.0 COG0625@1|root,COG0625@2|Bacteria,1RA05@1224|Proteobacteria,2TS58@28211|Alphaproteobacteria,43Y44@69657|Hyphomonadaceae 28211|Alphaproteobacteria O Glutathione S-transferase gstch8 - 2.5.1.18 ko:K00799 ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418 - R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905 RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944 ko00000,ko00001,ko01000,ko02000 1.A.12.2.2,1.A.12.3.2 - - GST_C,GST_C_2,GST_N,GST_N_3 k59_1719869_1 926550.CLDAP_16150 1.18e-61 204.0 COG2128@1|root,COG2128@2|Bacteria 2|Bacteria S hydroperoxide reductase activity - - - - - - - - - - - - CMD,DUF3179 k59_1265764_2 1122137.AQXF01000002_gene511 3.75e-131 383.0 COG5330@1|root,COG5330@2|Bacteria,1MXBZ@1224|Proteobacteria,2TT9C@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Uncharacterised protein conserved in bacteria (DUF2336) MA20_31465 - - - - - - - - - - - DUF2336 k59_475171_1 709032.Sulku_1805 7.7e-67 207.0 COG2606@1|root,COG2606@2|Bacteria,1RGX5@1224|Proteobacteria,42SKP@68525|delta/epsilon subdivisions,2YP6Z@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily ybaK - - ko:K03976 - - - - ko00000,ko01000,ko03016 - - - tRNA_edit k59_530815_1 1122613.ATUP01000001_gene1639 2.71e-38 138.0 COG0842@1|root,COG0842@2|Bacteria,1RFGP@1224|Proteobacteria,2TVTE@28211|Alphaproteobacteria,43ZNV@69657|Hyphomonadaceae 28211|Alphaproteobacteria V ABC-2 family transporter protein - - - - - - - - - - - - ABC2_membrane k59_419741_1 629265.PMA4326_04921 9.45e-65 215.0 COG1721@1|root,COG1721@2|Bacteria,1MXDI@1224|Proteobacteria,1RQSS@1236|Gammaproteobacteria,1Z8J5@136849|Pseudomonas syringae group 1236|Gammaproteobacteria S Protein of unknown function DUF58 - - - - - - - - - - - - DUF58 k59_419741_2 1205753.A989_10250 1.68e-138 402.0 COG0714@1|root,COG0714@2|Bacteria,1MUFN@1224|Proteobacteria,1RN5G@1236|Gammaproteobacteria,1X51C@135614|Xanthomonadales 135614|Xanthomonadales S ATPase family associated with various cellular activities (AAA) - - - ko:K03924 - - - - ko00000,ko01000 - - - AAA_3 k59_1607181_2 1206741.BAFX01000095_gene4677 1.1e-15 77.0 COG1960@1|root,COG1960@2|Bacteria,2HY6H@201174|Actinobacteria,4FVKT@85025|Nocardiaceae 201174|Actinobacteria I Acyl-CoA dehydrogenase, C-terminal domain - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_1265775_1 316407.1736788 7.24e-55 176.0 COG0745@1|root,COG0745@2|Bacteria,1MVCB@1224|Proteobacteria,1RMD0@1236|Gammaproteobacteria,3XMHX@561|Escherichia 1236|Gammaproteobacteria K Member of the two-component regulatory system BaeS BaeR which responds to envelope stress. Activates expression of periplasmic chaperone spy in response to spheroplast formation, indole and P pili protein PapG overexpression. Activates the mdtABCD and probably the CRISPR-Cas casABCDE-ygbT-ygbF operon baeR GO:0000976,GO:0000984,GO:0000986,GO:0000987,GO:0001017,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031334,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0042802,GO:0043170,GO:0043254,GO:0043565,GO:0044087,GO:0044089,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0045893,GO:0045935,GO:0046483,GO:0048518,GO:0048522,GO:0048583,GO:0050789,GO:0050794,GO:0051128,GO:0051130,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2000142,GO:2000144,GO:2001023,GO:2001141 - ko:K07664,ko:K18144 ko01501,ko02020,map01501,map02020 M00450,M00645,M00646,M00648,M00649,M00655 - - ko00000,ko00001,ko00002,ko01504,ko02022 - - - Response_reg,Trans_reg_C k59_1265775_2 316407.85675212 1.06e-42 140.0 COG3422@1|root,COG3422@2|Bacteria,1N0S6@1224|Proteobacteria,1S8R7@1236|Gammaproteobacteria,3XPP9@561|Escherichia 1236|Gammaproteobacteria S double-strand break repair yegP GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360 - ko:K09946 - - - - ko00000 - - - DUF1508 k59_1043105_1 1122137.AQXF01000001_gene3025 3.94e-47 164.0 COG0195@1|root,COG0195@2|Bacteria,1MWT7@1224|Proteobacteria,2TRQN@28211|Alphaproteobacteria 28211|Alphaproteobacteria K Participates in both transcription termination and antitermination nusA - - ko:K02600 - - - - ko00000,ko03009,ko03021 - - - HHH_5,KH_5,NusA_N,S1 k59_1043105_2 1122137.AQXF01000001_gene3026 3.42e-90 269.0 COG0779@1|root,COG0779@2|Bacteria,1RDP2@1224|Proteobacteria,2TS4E@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Required for maturation of 30S ribosomal subunits rimP GO:0000028,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576 - ko:K09748 - - - - ko00000,ko03009 - - - DUF150,DUF150_C k59_25337_1 314230.DSM3645_20632 2.49e-80 270.0 COG1201@1|root,COG1201@2|Bacteria,2IX0G@203682|Planctomycetes 203682|Planctomycetes L DEAD DEAH box helicase - - - ko:K03724 - - - - ko00000,ko01000,ko03400 - - - DEAD,DEAD_assoc,Helicase_C k59_25337_2 1265505.ATUG01000001_gene4149 6.7e-88 272.0 COG0002@1|root,COG0002@2|Bacteria,1MVJ6@1224|Proteobacteria,42MDN@68525|delta/epsilon subdivisions,2WINX@28221|Deltaproteobacteria,2MI9X@213118|Desulfobacterales 28221|Deltaproteobacteria E Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde argC - 1.2.1.38 ko:K00145,ko:K05829 ko00220,ko00300,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01130,map01210,map01230 M00028,M00031,M00763,M00845 R03443,R09777,R10931 RC00684 ko00000,ko00001,ko00002,ko01000 - - - Semialdhyde_dh,Semialdhyde_dhC k59_1211406_1 765914.ThisiDRAFT_0886 2.03e-52 187.0 COG5009@1|root,COG5009@2|Bacteria,1MU5A@1224|Proteobacteria,1RM7J@1236|Gammaproteobacteria,1WWH1@135613|Chromatiales 135613|Chromatiales M TIGRFAM penicillin-binding protein, 1A - - 2.4.1.129,3.4.16.4 ko:K05366 ko00550,ko01100,ko01501,map00550,map01100,map01501 - - - ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 - PCB_OB,Transgly,Transpeptidase k59_250457_1 519989.ECTPHS_01229 7.54e-152 446.0 COG0376@1|root,COG0376@2|Bacteria,1MUBF@1224|Proteobacteria,1RNA5@1236|Gammaproteobacteria,1WWMA@135613|Chromatiales 135613|Chromatiales P Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity katG - 1.11.1.21 ko:K03782 ko00360,ko00380,ko00940,ko00983,ko01100,ko01110,map00360,map00380,map00940,map00983,map01100,map01110 - R00602,R00698,R02596,R02670,R03919,R04007,R07443,R11906 RC00034,RC00213,RC00767,RC02141 ko00000,ko00001,ko01000 - - - peroxidase k59_1154104_1 748247.AZKH_3413 3.49e-73 235.0 COG1250@1|root,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,2VK75@28216|Betaproteobacteria 28216|Betaproteobacteria I 3-hydroxyacyl-CoA dehydrogenase paaH - 1.1.1.157 ko:K00074 ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120 - R01976,R05576,R06941 RC00029,RC00117 ko00000,ko00001,ko01000 - - - 3HCDH,3HCDH_N k59_82566_1 1313172.YM304_39270 1.63e-142 428.0 COG0247@1|root,COG2181@1|root,COG0247@2|Bacteria,COG2181@2|Bacteria,2GJ7M@201174|Actinobacteria,4CMWD@84992|Acidimicrobiia 84992|Acidimicrobiia C 4Fe-4S dicluster domain - - - - - - - - - - - - CCG,Fer4_8 k59_1774126_1 1250006.JHZZ01000001_gene1162 5.09e-45 161.0 2EKM2@1|root,33EAV@2|Bacteria,4NZ79@976|Bacteroidetes,1I8C7@117743|Flavobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_419758_1 1173029.JH980292_gene2085 1.79e-07 53.1 COG0642@1|root,COG2199@1|root,COG2202@1|root,COG3829@1|root,COG2202@2|Bacteria,COG2205@2|Bacteria,COG3706@2|Bacteria,COG3829@2|Bacteria,1FZWU@1117|Cyanobacteria,1H8MG@1150|Oscillatoriales 1117|Cyanobacteria T GGDEF domain' - - - - - - - - - - - - GAF,GAF_2,GAF_3,GGDEF,PAS_3,PAS_4,PAS_8,PAS_9 k59_82567_1 158500.BV97_01312 1.35e-111 328.0 COG1995@1|root,COG1995@2|Bacteria,1MX5W@1224|Proteobacteria,2TSKF@28211|Alphaproteobacteria,2K0HZ@204457|Sphingomonadales 204457|Sphingomonadales H Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) pdxA - 1.1.1.262 ko:K00097 ko00750,ko01100,map00750,map01100 M00124 R05681,R05837,R07406 RC00089,RC00675,RC01475 ko00000,ko00001,ko00002,ko01000 - - - PdxA k59_475200_1 1123400.KB904817_gene1460 2.61e-120 364.0 COG0480@1|root,COG0480@2|Bacteria,1MUCV@1224|Proteobacteria,1RNSZ@1236|Gammaproteobacteria,46061@72273|Thiotrichales 72273|Thiotrichales J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome fusA - - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2 k59_814389_1 765913.ThidrDRAFT_0025 9.34e-23 99.0 COG0643@1|root,COG0643@2|Bacteria,1MUAG@1224|Proteobacteria,1RMS6@1236|Gammaproteobacteria,1WWZQ@135613|Chromatiales 135613|Chromatiales T response regulator receiver - - - - - - - - - - - - CheW,HATPase_c,Hpt,Response_reg k59_1663606_1 301.JNHE01000006_gene1198 1.35e-75 234.0 COG0189@1|root,COG0189@2|Bacteria,1MX62@1224|Proteobacteria,1RM8B@1236|Gammaproteobacteria,1YD38@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria F Belongs to the RimK family rimK GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0016874,GO:0016879,GO:0016881,GO:0018169,GO:0018410,GO:0019538,GO:0031668,GO:0033554,GO:0036211,GO:0042802,GO:0043170,GO:0043412,GO:0043687,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0050896,GO:0051716,GO:0070739,GO:0071496,GO:0071704,GO:0140096,GO:1901564 - ko:K05844 - - - - ko00000,ko01000,ko03009 - - - RimK k59_928236_1 199310.c3114 1.53e-135 407.0 COG0542@1|root,COG0542@2|Bacteria,1MURH@1224|Proteobacteria,1RN55@1236|Gammaproteobacteria,3XN3I@561|Escherichia 1236|Gammaproteobacteria O Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE clpB GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0006950,GO:0006986,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009266,GO:0009408,GO:0009628,GO:0010033,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030554,GO:0031249,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0035966,GO:0036094,GO:0042221,GO:0042623,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564 - ko:K03695 ko04213,map04213 - - - ko00000,ko00001,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N k59_139286_1 1122604.JONR01000050_gene3127 5.5e-113 332.0 COG1137@1|root,COG1137@2|Bacteria,1MU8M@1224|Proteobacteria,1RPW1@1236|Gammaproteobacteria,1X31A@135614|Xanthomonadales 135614|Xanthomonadales S abc transporter atp-binding protein lptB - - ko:K06861 ko02010,map02010 M00320 - - ko00000,ko00001,ko00002,ko01000,ko02000 1.B.42.1 - - ABC_tran,BCA_ABC_TP_C k59_1098009_1 702113.PP1Y_AT24676 8.17e-95 293.0 COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,2TR1I@28211|Alphaproteobacteria,2K0GG@204457|Sphingomonadales 204457|Sphingomonadales EH COG0028 Thiamine pyrophosphate-requiring enzymes acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase ilvB - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_1098009_2 1088721.NSU_0061 5.17e-50 162.0 COG0440@1|root,COG0440@2|Bacteria,1RAGN@1224|Proteobacteria,2U5CW@28211|Alphaproteobacteria,2K12R@204457|Sphingomonadales 204457|Sphingomonadales E acetolactate synthase ilvH - 2.2.1.6 ko:K01653 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - ACT,ACT_5,ALS_ss_C k59_874513_1 365044.Pnap_1637 5.24e-38 140.0 COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,2VJ5H@28216|Betaproteobacteria,4ADA8@80864|Comamonadaceae 28216|Betaproteobacteria L Transposase IS116 IS110 IS902 family protein - - - ko:K07486 - - - - ko00000 - - - DEDD_Tnp_IS110,Transposase_20 k59_1155029_1 932677.PAJ_3044 2.13e-08 54.3 COG0129@1|root,COG0129@2|Bacteria,1MUTQ@1224|Proteobacteria,1RMP2@1236|Gammaproteobacteria,3VXP8@53335|Pantoea 1236|Gammaproteobacteria EG Belongs to the IlvD Edd family ilvD GO:0003674,GO:0003824,GO:0004160,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006549,GO:0006573,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009097,GO:0009099,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.2.1.9 ko:K01687 ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R01209,R04441,R05070 RC00468,RC01714 ko00000,ko00001,ko00002,ko01000 - - iECIAI39_1322.ECIAI39_3015 ILVD_EDD k59_1155029_2 199310.c4694 6.68e-136 397.0 COG1171@1|root,COG1171@2|Bacteria,1MVWJ@1224|Proteobacteria,1RMY6@1236|Gammaproteobacteria,3XN65@561|Escherichia 1236|Gammaproteobacteria E Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA ilvA GO:0003674,GO:0003824,GO:0004794,GO:0005488,GO:0006082,GO:0006520,GO:0006549,GO:0006566,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009081,GO:0009082,GO:0009097,GO:0009987,GO:0016053,GO:0016597,GO:0016829,GO:0016840,GO:0016841,GO:0019752,GO:0019842,GO:0030170,GO:0031406,GO:0036094,GO:0043167,GO:0043168,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.3.1.19 ko:K01754 ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230 M00570 R00220,R00996 RC00418,RC02600 ko00000,ko00001,ko00002,ko01000 - - iAPECO1_1312.APECO1_2699 PALP,Thr_dehydrat_C k59_1721109_1 398525.KB900701_gene4276 1.13e-27 120.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,2U063@28211|Alphaproteobacteria,3JTI0@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria NT Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - MCPsignal,PAS_4,PAS_8 k59_1098015_1 199310.c0831 2.4e-67 209.0 COG0588@1|root,COG0588@2|Bacteria,1MUVE@1224|Proteobacteria,1RNCX@1236|Gammaproteobacteria,3XMC6@561|Escherichia 1236|Gammaproteobacteria F Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily gpmA GO:0003674,GO:0003824,GO:0004619,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006109,GO:0006139,GO:0006140,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009894,GO:0009987,GO:0010675,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016866,GO:0016868,GO:0017144,GO:0018130,GO:0019219,GO:0019220,GO:0019222,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0031323,GO:0031329,GO:0032787,GO:0034248,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0043455,GO:0043456,GO:0043470,GO:0043471,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046538,GO:0046700,GO:0046939,GO:0050789,GO:0050794,GO:0051171,GO:0051174,GO:0051186,GO:0051188,GO:0051193,GO:0051196,GO:0055086,GO:0060255,GO:0062012,GO:0065007,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0080090,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1902031 5.4.2.11 ko:K01834 ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko05230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map05230 M00001,M00002,M00003 R01518 RC00536 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - His_Phos_1 k59_194342_1 1283299.AUKG01000001_gene1448 5.12e-15 78.6 COG1714@1|root,COG1714@2|Bacteria,2HP4S@201174|Actinobacteria,4CQGE@84995|Rubrobacteria 84995|Rubrobacteria S RDD family - - - - - - - - - - - - RDD k59_704138_2 394221.Mmar10_2123 2.32e-46 153.0 COG0853@1|root,COG0853@2|Bacteria,1RI1B@1224|Proteobacteria,2UASW@28211|Alphaproteobacteria,440WS@69657|Hyphomonadaceae 28211|Alphaproteobacteria H Aspartate decarboxylase panD - 4.1.1.11 ko:K01579 ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110 M00119 R00489 RC00299 ko00000,ko00001,ko00002,ko01000 - - - Asp_decarbox k59_1608415_1 1229909.NSED_08440 2.27e-13 67.4 COG1936@1|root,arCOG01038@2157|Archaea,41SPH@651137|Thaumarchaeota 651137|Thaumarchaeota F Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates - - 2.7.4.3 ko:K18532 ko00230,ko01100,ko01110,ko01130,ko03008,map00230,map01100,map01110,map01130,map03008 M00049 R00127,R01547 RC00002 ko00000,ko00001,ko00002,ko01000,ko03009 - - - AAA_18 k59_1608415_2 1229909.NSED_08435 4.78e-148 426.0 COG0012@1|root,arCOG00357@2157|Archaea,41S71@651137|Thaumarchaeota 651137|Thaumarchaeota J GTPase of unknown function C-terminal - - - ko:K06942 - - - - ko00000,ko03009 - - - MMR_HSR1,MMR_HSR1_C,TGS k59_1552438_1 1380600.AUYN01000001_gene2362 1.54e-62 204.0 COG1109@1|root,COG1109@2|Bacteria,4NG3H@976|Bacteroidetes,1HWVH@117743|Flavobacteriia 976|Bacteroidetes G Phosphoglucosamine mutase glmM - 5.4.2.8 ko:K01840 ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130 M00114 R01818 RC00408 ko00000,ko00001,ko00002,ko01000 - - - PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV k59_1552438_2 983544.Lacal_2831 1.55e-32 124.0 COG0520@1|root,COG0520@2|Bacteria,4NERR@976|Bacteroidetes,1HY99@117743|Flavobacteriia 976|Bacteroidetes E selenocysteine lyase - - - - - - - - - - - - Aminotran_5 k59_1721123_1 583355.Caka_2618 3.44e-75 236.0 COG3637@1|root,COG3637@2|Bacteria 2|Bacteria M Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety - - - - - - - - - - - - - k59_1382613_2 1121430.JMLG01000004_gene875 3.43e-12 70.1 COG3829@1|root,COG3829@2|Bacteria,1TP0E@1239|Firmicutes,247MB@186801|Clostridia,260UC@186807|Peptococcaceae 186801|Clostridia KT Bacterial regulatory protein, Fis family - - - - - - - - - - - - CBS,HTH_8,PAS,PAS_4,PAS_9,Sigma54_activat k59_1266981_1 331869.BAL199_06624 1.43e-107 317.0 COG1173@1|root,COG1173@2|Bacteria,1PFAG@1224|Proteobacteria,2V8S7@28211|Alphaproteobacteria,4BS73@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria EP Binding-protein-dependent transport system inner membrane component - - - - - - - - - - - - BPD_transp_1 k59_1721131_1 203122.Sde_2975 5.39e-137 396.0 COG0683@1|root,COG0683@2|Bacteria,1MU8V@1224|Proteobacteria,1RMIJ@1236|Gammaproteobacteria,46675@72275|Alteromonadaceae 1236|Gammaproteobacteria E COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component - - - ko:K11959 ko02010,map02010 M00323 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4.4,3.A.1.4.5 - - Peripla_BP_5 k59_1044310_1 33035.JPJF01000100_gene3576 4.39e-31 120.0 COG3958@1|root,COG3958@2|Bacteria,1V0K5@1239|Firmicutes,24914@186801|Clostridia,3XZRN@572511|Blautia 186801|Clostridia G Psort location Cytoplasmic, score 8.87 tktB - 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 - - - Transket_pyr,Transketolase_C k59_1774853_1 1484460.JSWG01000015_gene1150 2.23e-137 396.0 COG3823@1|root,COG3823@2|Bacteria,4NF2M@976|Bacteroidetes,1HY29@117743|Flavobacteriia 976|Bacteroidetes O Glutamine cyclotransferase - - 2.3.2.5 ko:K00683 - - - - ko00000,ko01000 - - - Glu_cyclase_2 k59_928260_1 247634.GPB2148_2639 8.99e-127 386.0 COG1520@1|root,COG1520@2|Bacteria,1QU2U@1224|Proteobacteria,1S1NX@1236|Gammaproteobacteria,1J7KA@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S PQQ-like domain - - 1.1.2.6 ko:K05889 - - R03136 - ko00000,ko01000 - - - Cytochrome_CBB3,PQQ,PQQ_2,PQQ_3 k59_420561_1 269796.Rru_A2425 8.31e-43 156.0 COG4783@1|root,COG4783@2|Bacteria,1MVFV@1224|Proteobacteria,2TTV2@28211|Alphaproteobacteria,2JP90@204441|Rhodospirillales 204441|Rhodospirillales S Zn-dependent protease, contains TPR repeats - - - - - - - - - - - - Peptidase_M48,TPR_16 k59_366231_1 688246.Premu_1129 2.95e-09 61.6 COG0212@1|root,COG0212@2|Bacteria,4NQRG@976|Bacteroidetes,2FQQB@200643|Bacteroidia 976|Bacteroidetes H Belongs to the 5-formyltetrahydrofolate cyclo-ligase family fthC - 6.3.3.2 ko:K01934 ko00670,ko01100,map00670,map01100 - R02301 RC00183 ko00000,ko00001,ko01000 - - - 5-FTHF_cyc-lig k59_983873_2 1123502.AQXD01000001_gene549 3.88e-73 222.0 COG0102@1|root,COG0102@2|Bacteria,1RA11@1224|Proteobacteria,1S280@1236|Gammaproteobacteria,1X61V@135614|Xanthomonadales 135614|Xanthomonadales J This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly rplM GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02871 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L13 k59_983873_3 998674.ATTE01000001_gene4320 2.15e-05 44.7 COG0103@1|root,COG0103@2|Bacteria,1RD4A@1224|Proteobacteria,1S3Q7@1236|Gammaproteobacteria,460TA@72273|Thiotrichales 72273|Thiotrichales J Belongs to the universal ribosomal protein uS9 family rpsI - - ko:K02996 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S9 k59_139324_1 1122137.AQXF01000007_gene3513 2.11e-132 387.0 COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,2TRN7@28211|Alphaproteobacteria 28211|Alphaproteobacteria C COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes lpdA - 1.8.1.4 ko:K00382 ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00036,M00307,M00532 R00209,R01221,R01698,R03815,R07618,R08549 RC00004,RC00022,RC00583,RC02742,RC02833,RC02834 br01601,ko00000,ko00001,ko00002,ko01000,ko04147 - - - Biotin_lipoyl,Pyr_redox_2,Pyr_redox_dim k59_590894_1 1097668.BYI23_C001410 5.21e-19 87.4 COG1804@1|root,COG1804@2|Bacteria,1MVY1@1224|Proteobacteria,2VKB0@28216|Betaproteobacteria,1K405@119060|Burkholderiaceae 28216|Betaproteobacteria C CoA-transferase family III - - - - - - - - - - - - CoA_transf_3 k59_590894_2 377629.TERTU_1087 1.52e-118 359.0 COG1116@1|root,COG1116@2|Bacteria,1MUDV@1224|Proteobacteria,1RNEH@1236|Gammaproteobacteria,2PMQH@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria P ABC transporter nrtC - - ko:K15578 ko00910,ko02010,map00910,map02010 M00438 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.16.1 - - ABC_tran k59_874563_1 455632.SGR_4238 1.28e-07 58.5 COG2197@1|root,COG2197@2|Bacteria,2IATK@201174|Actinobacteria,41C38@629295|Streptomyces griseus group 201174|Actinobacteria K helix_turn_helix, Lux Regulon - - - - - - - - - - - - GerE k59_531638_1 420324.KI911934_gene172 8.82e-23 96.3 COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,2TQTP@28211|Alphaproteobacteria,1JXEF@119045|Methylobacteriaceae 28211|Alphaproteobacteria L Transposase - - - ko:K07486 - - - - ko00000 - - - DEDD_Tnp_IS110,Transposase_20 k59_251625_2 339670.Bamb_3894 1.38e-76 236.0 COG5588@1|root,COG5588@2|Bacteria,1RGIE@1224|Proteobacteria,2VNWW@28216|Betaproteobacteria,1KHHM@119060|Burkholderiaceae 28216|Betaproteobacteria S Protein of unknown function (DUF1326) - - - - - - - - - - - - DUF1326 k59_1552483_1 330214.NIDE1331 1.17e-104 314.0 COG0201@1|root,COG0201@2|Bacteria,3J0C0@40117|Nitrospirae 40117|Nitrospirae U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently secY - - ko:K03076 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5 - - SecY k59_83806_1 436308.Nmar_0002 2.65e-109 328.0 COG1311@1|root,arCOG04455@2157|Archaea,41T0D@651137|Thaumarchaeota 651137|Thaumarchaeota L Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase polB - 2.7.7.7 ko:K02323 ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030 M00264 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032 - - - DNA_pol_E_B k59_645756_1 1122137.AQXF01000001_gene3184 2.79e-164 481.0 COG0280@1|root,COG0281@1|root,COG0280@2|Bacteria,COG0281@2|Bacteria,1MU0A@1224|Proteobacteria,2TQJT@28211|Alphaproteobacteria 28211|Alphaproteobacteria C Malic enzyme tme - 1.1.1.40 ko:K00029 ko00620,ko00710,ko01100,ko01120,ko01200,map00620,map00710,map01100,map01120,map01200 M00169,M00172 R00216 RC00105 ko00000,ko00001,ko00002,ko01000 - - - Malic_M,PTA_PTB,malic k59_590917_1 498211.CJA_0466 3.38e-47 171.0 COG3605@1|root,COG3605@2|Bacteria,1QTTV@1224|Proteobacteria,1T1H2@1236|Gammaproteobacteria,1FFWP@10|Cellvibrio 1236|Gammaproteobacteria H PEP-utilising enzyme, mobile domain ptsP GO:0003674,GO:0003824,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008965,GO:0009987,GO:0010033,GO:0010243,GO:0016310,GO:0016740,GO:0016772,GO:0016775,GO:0019538,GO:0036211,GO:0042221,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0050896,GO:0071704,GO:1901564,GO:1901698 2.7.3.9 ko:K08484 ko02060,map02060 - - - ko00000,ko00001,ko01000,ko02000 - - - GAF,GAF_2,PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C k59_1212628_1 436308.Nmar_0729 7.55e-78 236.0 COG0605@1|root,arCOG04147@2157|Archaea,41S6C@651137|Thaumarchaeota 651137|Thaumarchaeota P Destroys radicals which are normally produced within the cells and which are toxic to biological systems - - 1.15.1.1 ko:K04564 ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016 - - - ko00000,ko00001,ko01000 - - - Sod_Fe_C,Sod_Fe_N k59_309423_1 1415778.JQMM01000001_gene150 1.54e-123 369.0 COG0606@1|root,COG0606@2|Bacteria,1MU4R@1224|Proteobacteria,1RMB9@1236|Gammaproteobacteria,1J5DV@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O ATPase with chaperone activity comM GO:0003674,GO:0003824,GO:0004176,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019538,GO:0042623,GO:0043170,GO:0044238,GO:0070011,GO:0071704,GO:0140096,GO:1901564 - ko:K07391 - - - - ko00000 - - - ChlI,Mg_chelatase,Mg_chelatase_C k59_1436415_2 1122137.AQXF01000001_gene3051 1.43e-98 289.0 COG4567@1|root,COG4567@2|Bacteria,1RD7J@1224|Proteobacteria,2TSK7@28211|Alphaproteobacteria 28211|Alphaproteobacteria T Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain regA GO:0000156,GO:0000160,GO:0003674,GO:0007154,GO:0007165,GO:0008150,GO:0009987,GO:0023052,GO:0035556,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0060089,GO:0065007 - ko:K15012 ko02020,map02020 M00523 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg k59_1552517_1 58123.JOFJ01000016_gene4022 3.51e-13 72.4 COG1309@1|root,COG1309@2|Bacteria,2INPS@201174|Actinobacteria 201174|Actinobacteria K Bacterial regulatory proteins, tetR family - - - - - - - - - - - - TetR_N k59_815131_1 697282.Mettu_1451 5.63e-122 364.0 COG0147@1|root,COG0147@2|Bacteria,1MVBJ@1224|Proteobacteria,1RMSE@1236|Gammaproteobacteria,1XEVV@135618|Methylococcales 1236|Gammaproteobacteria EH Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia trpE - 4.1.3.27 ko:K01657 ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025 M00023 R00985,R00986 RC00010,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 - - - Anth_synt_I_N,Chorismate_bind k59_1436418_1 158500.BV97_02228 3.49e-101 325.0 COG1215@1|root,COG1215@2|Bacteria,1MWF8@1224|Proteobacteria,2TS1X@28211|Alphaproteobacteria,2K1J5@204457|Sphingomonadales 204457|Sphingomonadales M Cellulose synthase - - 2.4.1.12 ko:K00694,ko:K20541 ko00500,ko01100,ko02026,map00500,map01100,map02026 - R02889 RC00005 ko00000,ko00001,ko01000,ko01003,ko02000 4.D.3.1.2,4.D.3.1.5,4.D.3.1.6 GT2 - BcsB,Cellulose_synt,Glycos_transf_2,PilZ k59_983907_1 1380600.AUYN01000009_gene2061 2.3e-62 211.0 COG1480@1|root,COG1480@2|Bacteria,4NEHV@976|Bacteroidetes,1HXZU@117743|Flavobacteriia 976|Bacteroidetes S 7TM receptor with intracellular HD hydrolase - - - ko:K07037 - - - - ko00000 - - - 7TM-7TMR_HD,7TMR-HDED,HD k59_1330861_2 765914.ThisiDRAFT_1830 5.17e-12 68.9 COG1639@1|root,COG1639@2|Bacteria,1N7EN@1224|Proteobacteria,1RT8G@1236|Gammaproteobacteria,1WXU4@135613|Chromatiales 135613|Chromatiales T PFAM Metal-dependent hydrolase HDOD - - - - - - - - - - - - HDOD,bPH_2 k59_1781026_1 1250006.JHZZ01000001_gene1379 3.54e-52 186.0 COG0433@1|root,COG0433@2|Bacteria,4NVJM@976|Bacteroidetes,1I7IY@117743|Flavobacteriia,3VX4H@52959|Polaribacter 976|Bacteroidetes S TraM recognition site of TraD and TraG - - - - - - - - - - - - DUF87,TraG-D_C,TrwB_AAD_bind k59_653103_2 1229909.NSED_02815 8.77e-106 318.0 COG0043@1|root,arCOG01671@2157|Archaea,41S94@651137|Thaumarchaeota 651137|Thaumarchaeota H UbiD family decarboxylase - - 4.1.1.98 ko:K03182 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00117 R04985,R04986 RC00391 ko00000,ko00001,ko00002,ko01000 - - - UbiD k59_427587_1 1122137.AQXF01000003_gene2200 2.35e-84 259.0 COG3239@1|root,COG3239@2|Bacteria,1MW29@1224|Proteobacteria,2TSHW@28211|Alphaproteobacteria 28211|Alphaproteobacteria I Alkane 1-monooxygenase - - 1.14.15.3 ko:K00496 ko00071,ko00930,map00071,map00930 - R01347,R02281,R06945 RC00478 ko00000,ko00001,ko01000 - - - FA_desaturase k59_1563055_1 266117.Rxyl_2496 2.14e-11 68.2 COG0404@1|root,COG0446@1|root,COG0404@2|Bacteria,COG0446@2|Bacteria,2GMBK@201174|Actinobacteria 201174|Actinobacteria E Belongs to the GcvT family - - 1.5.3.1 ko:K00302 ko00260,ko01100,map00260,map01100 - R00610 RC00060,RC00557 ko00000,ko00001,ko01000 - - - FAD_oxidored,Fer2_4,GCV_T,GCV_T_C,Pyr_redox_2 k59_36425_1 545264.KB898751_gene2612 4.21e-72 232.0 COG0673@1|root,COG0673@2|Bacteria,1MV7C@1224|Proteobacteria,1SYTB@1236|Gammaproteobacteria,1WWFT@135613|Chromatiales 135613|Chromatiales S PFAM oxidoreductase - - - - - - - - - - - - GFO_IDH_MocA k59_262498_1 1122137.AQXF01000001_gene2959 1.44e-230 671.0 COG1074@1|root,COG1074@2|Bacteria,1MUTF@1224|Proteobacteria,2TQJZ@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Belongs to the helicase family. UvrD subfamily addA - 3.6.4.12 ko:K16898 - - - - ko00000,ko01000,ko03400 - - - PDDEXK_1,UvrD-helicase,UvrD_C k59_484126_1 1121271.AUCM01000009_gene2215 4.05e-48 162.0 COG5387@1|root,COG5387@2|Bacteria,1Q3B5@1224|Proteobacteria,2TVK1@28211|Alphaproteobacteria 28211|Alphaproteobacteria O COG5387 Chaperone required for the assembly of the mitochondrial F1-ATPase - - - - - - - - - - - - ATP12 k59_885849_1 436308.Nmar_0049 1.39e-76 235.0 COG0175@1|root,arCOG00124@2157|Archaea,41S9Q@651137|Thaumarchaeota 651137|Thaumarchaeota E Phosphoadenosine phosphosulfate reductase family - - 1.8.4.10,1.8.4.8 ko:K00390 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00176 R02021 RC00007,RC02862 ko00000,ko00001,ko00002,ko01000 - - - PAPS_reduct k59_1106405_1 314225.ELI_10675 1.34e-36 137.0 COG1629@1|root,COG4771@2|Bacteria,1MWKN@1224|Proteobacteria,2U3JH@28211|Alphaproteobacteria,2K1GK@204457|Sphingomonadales 204457|Sphingomonadales P receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_1394061_1 983920.Y88_0901 4.26e-27 108.0 COG0108@1|root,COG0807@1|root,COG0108@2|Bacteria,COG0807@2|Bacteria,1MU8P@1224|Proteobacteria,2TSMA@28211|Alphaproteobacteria,2K1FG@204457|Sphingomonadales 204457|Sphingomonadales H Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate ribB - 3.5.4.25,4.1.99.12 ko:K14652 ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110 M00125,M00840 R00425,R07281 RC00293,RC01792,RC01815,RC02504 ko00000,ko00001,ko00002,ko01000 - - - DHBP_synthase,GTP_cyclohydro2,SLT k59_1394061_2 1122137.AQXF01000002_gene66 1.31e-83 251.0 COG0307@1|root,COG0307@2|Bacteria,1MUMB@1224|Proteobacteria,2U3RS@28211|Alphaproteobacteria 28211|Alphaproteobacteria H riboflavin synthase alpha ribE GO:0003674,GO:0003824,GO:0004746,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.9 ko:K00793 ko00740,ko01100,ko01110,map00740,map01100,map01110 M00125 R00066 RC00958,RC00960 ko00000,ko00001,ko00002,ko01000 - - - Lum_binding k59_825490_1 745014.OMB55_00003830 4.35e-98 298.0 COG0404@1|root,COG0404@2|Bacteria,1MV96@1224|Proteobacteria,1RN2A@1236|Gammaproteobacteria 1236|Gammaproteobacteria E The glycine cleavage system catalyzes the degradation of glycine - - 2.1.2.10 ko:K00605 ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200 M00532 R01221,R02300,R04125 RC00022,RC00069,RC00183,RC02834 ko00000,ko00001,ko00002,ko01000 - - - DUF1989,GCV_T,GCV_T_C k59_1221863_1 1144319.PMI16_04513 5.58e-32 129.0 COG3209@1|root,COG3209@2|Bacteria,1R1SB@1224|Proteobacteria,2W3D6@28216|Betaproteobacteria 2|Bacteria M Salmonella virulence plasmid 65kDa B protein - - - - - - - - - - - - CHB_HEX_C_1,CotH,Flg_new,Fn3_assoc,LRR_5,LTD,Peptidase_S9,SpvB,TcdB_toxin_midN,VCBS k59_715453_1 76114.ebA3998 5.63e-34 127.0 COG0859@1|root,COG0859@2|Bacteria,1MXA2@1224|Proteobacteria,2VHHX@28216|Betaproteobacteria,2KVNC@206389|Rhodocyclales 206389|Rhodocyclales M Glycosyltransferase family 9 (heptosyltransferase) - - - ko:K02843 ko00540,ko01100,map00540,map01100 M00080 - - ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT9 - Glyco_transf_9 k59_715453_2 757424.Hsero_0665 2.84e-27 105.0 COG4319@1|root,COG4319@2|Bacteria,1MZK9@1224|Proteobacteria,2VU96@28216|Betaproteobacteria,474IC@75682|Oxalobacteraceae 28216|Betaproteobacteria S Domain of unknown function (DUF4440) - - - - - - - - - - - - SnoaL_3 k59_766590_1 1122137.AQXF01000002_gene594 3.14e-94 290.0 COG4664@1|root,COG4664@2|Bacteria,1R4MZ@1224|Proteobacteria,2TQNR@28211|Alphaproteobacteria 28211|Alphaproteobacteria Q TRAP-type mannitol chloroaromatic compound transport system large permease component - - - - - - - - - - - - DctM k59_428705_1 1229909.NSED_00830 3.12e-114 347.0 COG1042@1|root,arCOG01340@2157|Archaea,41S6N@651137|Thaumarchaeota 651137|Thaumarchaeota C Succinyl-CoA ligase like flavodoxin domain - - - ko:K18593 ko00720,ko01120,map00720,map01120 - R10758 RC00004,RC00014 ko00000,ko00001,ko01000 - - - ATP-grasp_5,CoA_binding_2,Succ_CoA_lig k59_428705_2 436308.Nmar_0205 8.66e-65 199.0 COG0328@1|root,arCOG02942@2157|Archaea,41SWJ@651137|Thaumarchaeota 651137|Thaumarchaeota L RNase H - - 3.1.26.4 ko:K03469 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - RVT_3 k59_1730009_1 243233.MCA0866 2.01e-11 66.2 COG1032@1|root,COG1032@2|Bacteria,1Q5NG@1224|Proteobacteria,1RQCS@1236|Gammaproteobacteria,1XG8E@135618|Methylococcales 135618|Methylococcales C Protein of unknown function (DUF4080) - - - - - - - - - - - - B12-binding,DUF4080,Radical_SAM k59_147386_2 436308.Nmar_0576 3.39e-58 184.0 COG3576@1|root,arCOG00518@2157|Archaea,41T47@651137|Thaumarchaeota 651137|Thaumarchaeota S Pyridoxamine 5'-phosphate oxidase - - - ko:K07006 - - - - ko00000 - - - Putative_PNPOx k59_428709_1 616991.JPOO01000001_gene3088 3.51e-34 130.0 COG3828@1|root,COG3828@2|Bacteria,4NEWH@976|Bacteroidetes,1I12W@117743|Flavobacteriia,23GUP@178469|Arenibacter 976|Bacteroidetes S Methane oxygenase PmoA - - - - - - - - - - - - PmoA k59_1221887_1 1224136.AMFN01000003_gene3251 1.9e-32 122.0 COG3435@1|root,COG3435@2|Bacteria,1MVJP@1224|Proteobacteria,1RYBU@1236|Gammaproteobacteria 1236|Gammaproteobacteria Q Gentisate 1,2-dioxygenase gtdA - 1.13.11.4 ko:K00450 ko00350,ko01100,ko01120,map00350,map01100,map01120 - R02656 RC00764 ko00000,ko00001,ko01000 - - - Cupin_2 k59_1564457_1 1565129.JSFF01000003_gene2156 6.5e-60 193.0 COG0632@1|root,COG0632@2|Bacteria,1MWJR@1224|Proteobacteria,1RMET@1236|Gammaproteobacteria,2Q8WE@267890|Shewanellaceae 1236|Gammaproteobacteria L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB ruvA GO:0000217,GO:0000400,GO:0000725,GO:0003674,GO:0003676,GO:0003677,GO:0003678,GO:0003824,GO:0004386,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0007154,GO:0008150,GO:0008152,GO:0009314,GO:0009378,GO:0009379,GO:0009432,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0022607,GO:0031668,GO:0032392,GO:0032508,GO:0032991,GO:0033202,GO:0033554,GO:0034641,GO:0042802,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0051259,GO:0051260,GO:0051262,GO:0051276,GO:0051289,GO:0051716,GO:0065003,GO:0071103,GO:0071496,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1902494 3.6.4.12 ko:K03550 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - HHH_5,RuvA_C,RuvA_N k59_1564457_2 1415778.JQMM01000001_gene15 5.16e-42 147.0 COG2255@1|root,COG2255@2|Bacteria,1MU38@1224|Proteobacteria,1RNWY@1236|Gammaproteobacteria,1J4F2@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing ruvB GO:0000725,GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0007154,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009314,GO:0009378,GO:0009411,GO:0009416,GO:0009432,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0031668,GO:0032392,GO:0032508,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0051276,GO:0051716,GO:0070035,GO:0071103,GO:0071496,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360 3.6.4.12 ko:K03551 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - RuvB_C,RuvB_N k59_602505_1 1347369.CCAD010000094_gene2274 1.7e-66 225.0 COG0188@1|root,COG0188@2|Bacteria,1TP2Z@1239|Firmicutes,4HAHY@91061|Bacilli,1ZB8F@1386|Bacillus 91061|Bacilli L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrA - 5.99.1.3 ko:K02469 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseA_C,DNA_topoisoIV k59_1671937_1 1194165.CAJF01000004_gene2835 2.06e-139 410.0 COG0677@1|root,COG0677@2|Bacteria,2GK5K@201174|Actinobacteria,4FN1Y@85023|Microbacteriaceae 201174|Actinobacteria M UDP binding domain - - 1.1.1.336 ko:K02472 ko00520,ko05111,map00520,map05111 - R03317 RC00291 ko00000,ko00001,ko01000 - - - UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N k59_1671937_2 263358.VAB18032_15215 4.34e-27 107.0 COG0451@1|root,COG0451@2|Bacteria,2I9T0@201174|Actinobacteria,4DA9R@85008|Micromonosporales 201174|Actinobacteria GM GDP-mannose 4,6 dehydratase - - - - - - - - - - - - Epimerase k59_1782058_1 243365.CV_2560 3.22e-101 336.0 COG2373@1|root,COG2373@2|Bacteria,1MV7J@1224|Proteobacteria,2VI2R@28216|Betaproteobacteria,2KTDT@206351|Neisseriales 206351|Neisseriales S Alpha-2-Macroglobulin - - - ko:K06894 - - - - ko00000 - - - A2M,A2M_N,A2M_N_2,MG1 k59_321081_1 1304874.JAFY01000002_gene504 6.56e-54 180.0 COG2876@1|root,COG2876@2|Bacteria,3TA06@508458|Synergistetes 508458|Synergistetes E PFAM DAHP synthetase I aroF - 2.5.1.54 ko:K03856 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R01826 RC00435 ko00000,ko00001,ko00002,ko01000 - - - DAHP_synth_1 k59_766618_1 300852.55771716 2.36e-16 73.6 COG1993@1|root,COG1993@2|Bacteria,1WKB2@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus S Uncharacterized ACR, COG1993 - - - ko:K09137 - - - - ko00000 - - - DUF190 k59_766618_2 311424.DhcVS_1273 5.17e-21 89.0 COG0239@1|root,COG0239@2|Bacteria,2G760@200795|Chloroflexi,34DD6@301297|Dehalococcoidia 301297|Dehalococcoidia D Important for reducing fluoride concentration in the cell, thus reducing its toxicity crcB - - ko:K06199 - - - - ko00000,ko02000 1.A.43.1,1.A.43.2,1.A.43.3 - - CRCB k59_654353_1 436308.Nmar_1486 6.33e-67 205.0 COG2947@1|root,arCOG08640@2157|Archaea,41SK6@651137|Thaumarchaeota 651137|Thaumarchaeota S EVE domain - - - - - - - - - - - - EVE k59_1106468_1 62928.azo1537 1.95e-20 90.9 COG3576@1|root,COG3576@2|Bacteria,1N8Z5@1224|Proteobacteria,2VVVW@28216|Betaproteobacteria,2KX6P@206389|Rhodocyclales 206389|Rhodocyclales S pyridoxamine 5-phosphate - - - - - - - - - - - - - k59_992175_1 517418.Ctha_2180 1.99e-66 219.0 COG1249@1|root,COG1249@2|Bacteria,1FDB4@1090|Chlorobi 1090|Chlorobi C pyridine nucleotide-disulphide oxidoreductase dimerisation region - - 1.8.1.4 ko:K00382 ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00036,M00307,M00532 R00209,R01221,R01698,R03815,R07618,R08549 RC00004,RC00022,RC00583,RC02742,RC02833,RC02834 br01601,ko00000,ko00001,ko00002,ko01000,ko04147 - - - Pyr_redox_2,Pyr_redox_dim k59_602533_1 436308.Nmar_1573 5.09e-122 361.0 COG0519@1|root,arCOG00085@2157|Archaea,41SDI@651137|Thaumarchaeota 651137|Thaumarchaeota F Catalyzes the synthesis of GMP from XMP guaA - 6.3.5.2 ko:K01951 ko00230,ko00983,ko01100,map00230,map00983,map01100 M00050 R01230,R01231,R08244 RC00010,RC00204 ko00000,ko00001,ko00002,ko01000,ko01002 - - - GATase,GMP_synt_C,NAD_synthase k59_1617492_1 926566.Terro_2386 3.24e-17 84.3 COG2271@1|root,COG2271@2|Bacteria,3Y6AJ@57723|Acidobacteria,2JP3Q@204432|Acidobacteriia 57723|Acidobacteria G PFAM Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 k59_1617492_2 247639.MGP2080_02560 3.3e-11 64.7 2CEWZ@1|root,33QME@2|Bacteria,1NTHN@1224|Proteobacteria,1SKH8@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_1106479_1 555793.WSK_0679 1.29e-153 449.0 COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,2TQMR@28211|Alphaproteobacteria,2K0VT@204457|Sphingomonadales 204457|Sphingomonadales V ABC-type multidrug transport system, ATPase and permease - - - ko:K06147 - - - - ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran k59_1394122_1 290398.Csal_1665 1.6e-06 52.8 COG4961@1|root,COG4961@2|Bacteria 2|Bacteria U PFAM TadE family protein tadE - - ko:K02282,ko:K12513 - - - - ko00000,ko02035,ko02044 - - - TadE k59_37885_1 1123372.AUIT01000001_gene806 3.89e-07 57.0 COG2199@1|root,COG2905@1|root,COG2905@2|Bacteria,COG3706@2|Bacteria,2GHH1@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria T diguanylate cyclase - - - - - - - - - - - - CBS,GGDEF,PAS_9 k59_602545_1 502025.Hoch_6769 7.55e-15 78.2 COG2186@1|root,COG2186@2|Bacteria,1PFZY@1224|Proteobacteria,434A2@68525|delta/epsilon subdivisions,2X272@28221|Deltaproteobacteria,2Z2BH@29|Myxococcales 28221|Deltaproteobacteria K FCD - - - ko:K05799 - - - - ko00000,ko03000 - - - FCD,GntR k59_1331994_1 83406.HDN1F_28280 3.46e-98 308.0 COG4775@1|root,COG4775@2|Bacteria,1MU0D@1224|Proteobacteria,1RMAP@1236|Gammaproteobacteria,1J4CD@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane bamA GO:0005575,GO:0005623,GO:0008104,GO:0008150,GO:0009279,GO:0009987,GO:0016020,GO:0016043,GO:0019867,GO:0022607,GO:0030312,GO:0030313,GO:0031224,GO:0031230,GO:0031241,GO:0031246,GO:0031975,GO:0032991,GO:0033036,GO:0034613,GO:0043163,GO:0043165,GO:0044085,GO:0044091,GO:0044425,GO:0044462,GO:0044464,GO:0045184,GO:0045229,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0061024,GO:0070727,GO:0071709,GO:0071840,GO:0071944,GO:0072657,GO:0090150,GO:0098552,GO:0098796,GO:1990063 - ko:K07277 - - - - ko00000,ko02000,ko03029 1.B.33 - - Bac_surface_Ag,POTRA k59_1221937_1 1120953.AUBH01000001_gene809 3.66e-25 102.0 COG0448@1|root,COG0448@2|Bacteria,1MVTC@1224|Proteobacteria,1RP04@1236|Gammaproteobacteria,46442@72275|Alteromonadaceae 1236|Gammaproteobacteria H Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans glgC - 2.7.7.27 ko:K00975 ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026 M00565 R00948 RC00002 ko00000,ko00001,ko00002,ko01000 - - - NTP_transferase k59_1221937_2 1304866.K413DRAFT_0428 1.61e-13 71.6 COG1640@1|root,COG1640@2|Bacteria,1W5VQ@1239|Firmicutes,25E46@186801|Clostridia,36DWR@31979|Clostridiaceae 186801|Clostridia G 4-alpha-glucanotransferase malQ - 2.4.1.25 ko:K00705 ko00500,ko01100,map00500,map01100 - R05196 RC00049 ko00000,ko00001,ko01000 - GH77 - Glyco_hydro_77 k59_147455_1 1144275.COCOR_06542 2.08e-105 325.0 COG0624@1|root,COG0624@2|Bacteria,1MW20@1224|Proteobacteria,42N09@68525|delta/epsilon subdivisions,2WIRX@28221|Deltaproteobacteria,2YUYT@29|Myxococcales 28221|Deltaproteobacteria E Peptidase dimerisation domain - - - - - - - - - - - - M20_dimer,Peptidase_M20 k59_147455_2 1333998.M2A_2211 1.07e-06 50.4 COG4799@1|root,COG4799@2|Bacteria,1MVAX@1224|Proteobacteria,2TTB9@28211|Alphaproteobacteria,4BT9B@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria I Carboxyl transferase domain - - - - - - - - - - - - Carboxyl_trans k59_1617520_1 158500.BV97_00502 6.16e-106 326.0 COG1200@1|root,COG1200@2|Bacteria,1MWN2@1224|Proteobacteria,2TR86@28211|Alphaproteobacteria,2K0MC@204457|Sphingomonadales 204457|Sphingomonadales L ATP-dependent DNA helicase RecG recG - 3.6.4.12 ko:K03655 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,Helicase_C,RecG_wedge k59_1730066_1 765912.Thimo_2520 8.09e-58 192.0 COG4591@1|root,COG4591@2|Bacteria,1R4Q2@1224|Proteobacteria,1RQW0@1236|Gammaproteobacteria,1X1HR@135613|Chromatiales 135613|Chromatiales M ABC-type transport system, involved in lipoprotein release, permease component - - - - - - - - - - - - FtsX,MacB_PCD k59_1054032_1 1137281.D778_02182 9.02e-78 241.0 COG0061@1|root,COG0061@2|Bacteria,4NFG5@976|Bacteroidetes,1HY0R@117743|Flavobacteriia 976|Bacteroidetes H Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP nadK - 2.7.1.23 ko:K00858 ko00760,ko01100,map00760,map01100 - R00104 RC00002,RC00078 ko00000,ko00001,ko01000 - - - NAD_kinase k59_1054032_2 1197477.IA57_02935 1.17e-23 95.5 COG0517@1|root,COG0517@2|Bacteria,4NF8G@976|Bacteroidetes,1HXW4@117743|Flavobacteriia 976|Bacteroidetes S Acetoin utilization protein - - - - - - - - - - - - CBS k59_1106500_1 1000565.METUNv1_00353 5.59e-24 103.0 COG0457@1|root,COG0457@2|Bacteria,1Q84V@1224|Proteobacteria,2VJAQ@28216|Betaproteobacteria,2KUGG@206389|Rhodocyclales 206389|Rhodocyclales S Domain of unknown function (DUF4440) - - - - - - - - - - - - DUF4440,TPR_11,TPR_16,TPR_17 k59_1106502_2 290400.Jann_2345 3.49e-09 57.8 COG0697@1|root,COG0697@2|Bacteria,1MV7Y@1224|Proteobacteria,2TUVM@28211|Alphaproteobacteria 28211|Alphaproteobacteria EG COG0697 Permeases of the drug metabolite transporter (DMT) superfamily - - - - - - - - - - - - EamA k59_654399_2 1122137.AQXF01000005_gene1120 2.34e-105 315.0 COG2200@1|root,COG2200@2|Bacteria,1N299@1224|Proteobacteria,2U37V@28211|Alphaproteobacteria 28211|Alphaproteobacteria T Putative diguanylate phosphodiesterase - - - - - - - - - - - - EAL,Response_reg k59_1332008_2 2903.EOD26371 6.96e-30 123.0 2EJSG@1|root,2SPVR@2759|Eukaryota 2759|Eukaryota - - - - - - - - - - - - - - - k59_93596_2 1313172.YM304_10850 2.86e-29 111.0 COG3427@1|root,COG3427@2|Bacteria,2HGAK@201174|Actinobacteria,4CNA2@84992|Acidimicrobiia 84992|Acidimicrobiia E oxidoreductase activity, acting on CH-OH group of donors - - - - - - - - - - - - Polyketide_cyc2 k59_147471_1 436308.Nmar_1440 8.6e-35 132.0 COG0642@1|root,arCOG02358@2157|Archaea,41T5G@651137|Thaumarchaeota 651137|Thaumarchaeota T PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - HATPase_c,HisKA,dCache_1 k59_1165863_1 489825.LYNGBM3L_22980 1.07e-22 102.0 COG2211@1|root,COG2211@2|Bacteria,1G0ZY@1117|Cyanobacteria,1H6Y4@1150|Oscillatoriales 1117|Cyanobacteria G COG2211 Na melibiose symporter and related melB - - ko:K03292 - - - - ko00000 2.A.2 - - MFS_2 k59_936761_1 1123514.KB905901_gene153 2.18e-09 62.0 COG3745@1|root,COG3745@2|Bacteria 2|Bacteria U Flp pilus assembly protein CpaB cpaB - - ko:K02279 - - - - ko00000,ko02035,ko02044 - - - RcpC,SAF k59_654406_1 1121918.ARWE01000001_gene3240 8.88e-36 139.0 COG0715@1|root,COG4191@1|root,COG0715@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,43CE0@68525|delta/epsilon subdivisions 1224|Proteobacteria T Bacterial periplasmic substrate-binding proteins - - - - - - - - - - - - HATPase_c,HisKA,NMT1,PAS_3,PAS_4,PAS_9,Response_reg,SBP_bac_3 k59_825571_1 1463936.JOJI01000028_gene3168 1.3e-45 167.0 COG1252@1|root,COG1252@2|Bacteria,2GJFE@201174|Actinobacteria 201174|Actinobacteria C NADH dehydrogenase - - 1.6.99.3 ko:K03885 ko00190,map00190 - - - ko00000,ko00001,ko01000 - - - Pyr_redox_2 k59_37913_1 309801.trd_A0011 6.84e-10 65.1 COG1680@1|root,COG1680@2|Bacteria,2G6QM@200795|Chloroflexi,27XFJ@189775|Thermomicrobia 189775|Thermomicrobia V Beta-lactamase - - - - - - - - - - - - Beta-lactamase k59_1054051_1 994479.GL877880_gene3990 1.43e-09 58.5 COG0188@1|root,COG0188@2|Bacteria,2GJ2Q@201174|Actinobacteria,4DYNS@85010|Pseudonocardiales 201174|Actinobacteria L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrA GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0003916,GO:0003918,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006265,GO:0006725,GO:0006807,GO:0006996,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017076,GO:0017111,GO:0030312,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034335,GO:0034641,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0046872,GO:0051276,GO:0061505,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:0097367,GO:0140097,GO:1901265,GO:1901360,GO:1901363 5.99.1.3 ko:K02469 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseA_C,DNA_topoisoIV,Intein_splicing,LAGLIDADG_3 k59_262603_2 1201293.AKXQ01000001_gene1972 3.46e-31 123.0 COG1331@1|root,COG1331@2|Bacteria,1R6MC@1224|Proteobacteria,1S0AF@1236|Gammaproteobacteria 1236|Gammaproteobacteria O Highly conserved protein containing a thioredoxin domain - - - - - - - - - - - - - k59_1394161_1 261292.Nit79A3_0158 6.34e-35 134.0 COG5433@1|root,COG5433@2|Bacteria,1MXI8@1224|Proteobacteria,2W66H@28216|Betaproteobacteria 28216|Betaproteobacteria L PFAM Transposase, IS4-like - - - - - - - - - - - - - k59_1671999_1 199310.c3720 1.01e-119 353.0 COG2244@1|root,COG2244@2|Bacteria,1RDQG@1224|Proteobacteria,1RMK6@1236|Gammaproteobacteria,3XMZ2@561|Escherichia 1236|Gammaproteobacteria S Polysaccharide biosynthesis protein yghQ GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - - - - - - - - - - Polysacc_synt,Polysacc_synt_3 k59_262606_1 316407.85676363 1.24e-97 290.0 COG2207@1|root,COG2207@2|Bacteria,1R5IW@1224|Proteobacteria,1S033@1236|Gammaproteobacteria,3XRCD@561|Escherichia 1236|Gammaproteobacteria K sequence-specific DNA binding yidL GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576 - - - - - - - - - - AraC_binding,HTH_18,HTH_AraC k59_262606_2 155864.EDL933_5008 1.84e-30 117.0 COG1486@1|root,COG1486@2|Bacteria,1NI6G@1224|Proteobacteria,1RYKZ@1236|Gammaproteobacteria,3XP52@561|Escherichia 1236|Gammaproteobacteria G Family 4 glycosyl hydrolase aglB - 3.2.1.122,3.2.1.86 ko:K01222,ko:K01232 ko00010,ko00500,map00010,map00500 - R00837,R00838,R00839,R05133,R05134,R06113 RC00049,RC00171,RC00714 ko00000,ko00001,ko01000 - GH4,GT4 - Glyco_hydro_4,Glyco_hydro_4C k59_262606_3 155864.EDL933_5008 9.78e-20 87.4 COG1486@1|root,COG1486@2|Bacteria,1NI6G@1224|Proteobacteria,1RYKZ@1236|Gammaproteobacteria,3XP52@561|Escherichia 1236|Gammaproteobacteria G Family 4 glycosyl hydrolase aglB - 3.2.1.122,3.2.1.86 ko:K01222,ko:K01232 ko00010,ko00500,map00010,map00500 - R00837,R00838,R00839,R05133,R05134,R06113 RC00049,RC00171,RC00714 ko00000,ko00001,ko01000 - GH4,GT4 - Glyco_hydro_4,Glyco_hydro_4C k59_602598_1 316407.1799586 2.02e-227 627.0 COG0584@1|root,COG0584@2|Bacteria,1MVWZ@1224|Proteobacteria,1RRBP@1236|Gammaproteobacteria,3XP14@561|Escherichia 1236|Gammaproteobacteria C glycerophosphoryl diester phosphodiesterase glpQ GO:0003674,GO:0003824,GO:0005488,GO:0005509,GO:0005575,GO:0005623,GO:0008081,GO:0008889,GO:0009279,GO:0016020,GO:0016787,GO:0016788,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0042578,GO:0042597,GO:0043167,GO:0043169,GO:0044462,GO:0044464,GO:0046872,GO:0071944 3.1.4.46 ko:K01126 ko00564,map00564 - R01030,R01470 RC00017,RC00425 ko00000,ko00001,ko01000 - - iECNA114_1301.ECNA114_2331,iECSF_1327.ECSF_2119 GDPD k59_602598_2 316407.1799587 1.07e-10 61.6 COG2271@1|root,COG2271@2|Bacteria,1MX4V@1224|Proteobacteria,1RMB3@1236|Gammaproteobacteria,3XNBI@561|Escherichia 1236|Gammaproteobacteria P glycerol-phosphate:inorganic phosphate antiporter activity glpT GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006817,GO:0006820,GO:0008150,GO:0008509,GO:0008643,GO:0015075,GO:0015103,GO:0015114,GO:0015144,GO:0015166,GO:0015168,GO:0015291,GO:0015297,GO:0015301,GO:0015315,GO:0015318,GO:0015527,GO:0015698,GO:0015711,GO:0015748,GO:0015791,GO:0015793,GO:0015794,GO:0015850,GO:0016020,GO:0022804,GO:0022857,GO:0034219,GO:0034220,GO:0035435,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0098656,GO:0098660,GO:0098661,GO:0099516,GO:1901264,GO:1901618 - ko:K02445 - - - - ko00000,ko02000 2.A.1.4.3 - iECH74115_1262.ECH74115_3377,iECIAI39_1322.ECIAI39_2383,iECSP_1301.ECSP_3115,iECs_1301.ECs3125,iEcSMS35_1347.EcSMS35_2392,iG2583_1286.G2583_2780,iSFV_1184.SFV_2312,iZ_1308.Z3498 MFS_1 k59_1672002_1 436308.Nmar_0872 3.43e-115 338.0 COG1759@1|root,arCOG04346@2157|Archaea,41SBR@651137|Thaumarchaeota 651137|Thaumarchaeota F Catalyzes the ATP- and formate-dependent formylation of 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'- monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1- beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates purP - 6.3.4.23 ko:K06863 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R06975 RC00263,RC00323 ko00000,ko00001,ko00002,ko01000 - - - DUF1246,DUF1297 k59_766681_1 1122137.AQXF01000001_gene2728 1.5e-11 65.5 COG1680@1|root,COG1680@2|Bacteria,1P3SQ@1224|Proteobacteria,2TTI5@28211|Alphaproteobacteria 28211|Alphaproteobacteria V COG1680 Beta-lactamase class C and other penicillin binding proteins nylB - - - - - - - - - - - Beta-lactamase k59_766681_2 1122137.AQXF01000001_gene2727 2.81e-96 289.0 COG3239@1|root,COG3239@2|Bacteria,1MUHK@1224|Proteobacteria,2TSTR@28211|Alphaproteobacteria 28211|Alphaproteobacteria I Fatty acid desaturase MA20_28095 - - - - - - - - - - - FA_desaturase k59_943583_1 439292.Bsel_0663 6.42e-25 107.0 COG2211@1|root,COG2211@2|Bacteria,1TRP7@1239|Firmicutes,4HCUK@91061|Bacilli,26P6Z@186821|Sporolactobacillaceae 91061|Bacilli G MFS/sugar transport protein - - - - - - - - - - - - MFS_1 k59_1060633_1 631362.Thi970DRAFT_04030 2.88e-12 66.2 COG0767@1|root,COG0767@2|Bacteria,1MVPN@1224|Proteobacteria,1RYHN@1236|Gammaproteobacteria,1WXIV@135613|Chromatiales 135613|Chromatiales Q Permease MlaE - - - ko:K02066 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - MlaE,STAS_2 k59_1060633_2 335543.Sfum_2415 3.9e-56 182.0 COG1127@1|root,COG1127@2|Bacteria,1MUSD@1224|Proteobacteria,42NTG@68525|delta/epsilon subdivisions,2WKHW@28221|Deltaproteobacteria,2MQ9V@213462|Syntrophobacterales 28221|Deltaproteobacteria Q ABC-type transport system involved in resistance to organic solvents, ATPase component - - - ko:K02065 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - ABC_tran k59_1571308_1 1096930.L284_18600 5.91e-74 229.0 COG0745@1|root,COG0745@2|Bacteria,1MY5Y@1224|Proteobacteria,2VEVS@28211|Alphaproteobacteria,2K2SR@204457|Sphingomonadales 204457|Sphingomonadales T Transcriptional regulatory protein, C terminal - - - ko:K07666 ko02020,ko02024,map02020,map02024 M00453 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Trans_reg_C k59_999514_1 1112214.AHIS01000095_gene767 6.23e-61 202.0 COG0334@1|root,COG0334@2|Bacteria,1MUXS@1224|Proteobacteria,2VGKD@28211|Alphaproteobacteria,2K0AY@204457|Sphingomonadales 204457|Sphingomonadales E Belongs to the Glu Leu Phe Val dehydrogenases family - - 1.4.1.9 ko:K00263 ko00280,ko00290,ko01100,ko01110,ko01130,map00280,map00290,map01100,map01110,map01130 - R01088,R01434,R02196 RC00006,RC00036 ko00000,ko00001,ko01000 - - - ELFV_dehydrog,ELFV_dehydrog_N k59_1571312_1 247633.GP2143_03878 3.89e-90 288.0 COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MUT8@1224|Proteobacteria,1RN6R@1236|Gammaproteobacteria,1J5MR@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Pyruvate phosphate dikinase ppdK - 2.7.3.9,2.7.9.1,2.7.9.2 ko:K01006,ko:K01007,ko:K08483 ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,ko02060,map00620,map00680,map00710,map00720,map01100,map01120,map01200,map02060 M00169,M00171,M00172,M00173,M00374 R00199,R00206 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000,ko02000 8.A.7 - - PEP-utilizers,PEP-utilizers_C,PPDK_N k59_384282_1 1122137.AQXF01000003_gene2399 8.62e-70 226.0 COG3746@1|root,COG3746@2|Bacteria,1RA39@1224|Proteobacteria,2U9KD@28211|Alphaproteobacteria 28211|Alphaproteobacteria P PFAM Phosphate-selective porin O and P - - - ko:K07221 - - - - ko00000,ko02000 1.B.5.1 - - Porin_O_P k59_384282_2 1122137.AQXF01000004_gene1545 1.26e-93 278.0 COG0834@1|root,COG0834@2|Bacteria,1RHMR@1224|Proteobacteria,2U942@28211|Alphaproteobacteria 28211|Alphaproteobacteria ET ABC-type amino acid transport signal transduction systems periplasmic component domain - - - - - - - - - - - - - k59_269534_1 316407.85675615 6.11e-121 355.0 COG0814@1|root,COG0814@2|Bacteria,1NQFA@1224|Proteobacteria,1RQ8Q@1236|Gammaproteobacteria,3XMD0@561|Escherichia 1236|Gammaproteobacteria E Involved in the import of serine into the cell. May be required for phage C1 adsorption by interacting with DrcB. May also be involved in ampicillin sensitivity sdaC GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 - ko:K03837 - - - - ko00000,ko02000 2.A.42.2.1 - iAPECO1_1312.APECO1_3735,iE2348C_1286.E2348C_3063,iECABU_c1320.ECABU_c30650,iECED1_1282.ECED1_3249,iECNA114_1301.ECNA114_2835,iECOK1_1307.ECOK1_3172,iECP_1309.ECP_2778,iECS88_1305.ECS88_3065,iECSF_1327.ECSF_2587,iEcSMS35_1347.EcSMS35_2936,iLF82_1304.LF82_2096,iNRG857_1313.NRG857_13695,iPC815.YPO1321,iSDY_1059.SDY_3013,iUMN146_1321.UM146_02585,iUTI89_1310.UTI89_C3167,iYL1228.KPN_03139,ic_1306.c3364 Trp_Tyr_perm k59_384284_1 663610.JQKO01000013_gene1757 2.57e-47 165.0 COG2301@1|root,COG2301@2|Bacteria,1MW0A@1224|Proteobacteria,2TTC0@28211|Alphaproteobacteria,3NB0G@45404|Beijerinckiaceae 28211|Alphaproteobacteria G HpcH/HpaI aldolase/citrate lyase family - - 4.1.3.34 ko:K01644 ko02020,map02020 - R00362 RC00067,RC01118 ko00000,ko00001,ko01000 - - - HpcH_HpaI k59_1513821_1 479435.Kfla_2756 2.43e-18 88.6 COG0246@1|root,COG0246@2|Bacteria,2GJ4F@201174|Actinobacteria,4DPWW@85009|Propionibacteriales 201174|Actinobacteria G Mannitol dehydrogenase Rossmann domain - - 1.1.1.57,1.1.1.67 ko:K00040,ko:K00045 ko00040,ko00051,ko01100,map00040,map00051,map01100 M00061 R00868,R02454 RC00085 ko00000,ko00001,ko00002,ko01000 - - - Mannitol_dh,Mannitol_dh_C k59_1113493_1 556268.OFAG_00814 1.33e-10 60.8 2EX9E@1|root,33QK4@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_1623911_2 1026882.MAMP_01075 8.62e-25 100.0 COG5608@1|root,COG5608@2|Bacteria,1MZF0@1224|Proteobacteria,1SAHU@1236|Gammaproteobacteria,461F2@72273|Thiotrichales 72273|Thiotrichales S Late embryogenesis abundant protein - - - - - - - - - - - - LEA_2 k59_661831_1 983548.Krodi_0455 5.41e-53 178.0 COG0492@1|root,COG0492@2|Bacteria,4NEVX@976|Bacteroidetes,1HXE2@117743|Flavobacteriia,37DTC@326319|Dokdonia 976|Bacteroidetes C Pyridine nucleotide-disulphide oxidoreductase trxB - 1.8.1.9 ko:K00384 ko00450,map00450 - R02016,R03596,R09372 RC00013,RC02518,RC02873 ko00000,ko00001,ko01000 - - - Pyr_redox_2 k59_1172529_1 525904.Tter_1979 4.57e-09 58.9 COG2084@1|root,COG2084@2|Bacteria,2NP96@2323|unclassified Bacteria 2|Bacteria I NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase MA20_29235 - 1.1.1.31 ko:K00020 ko00280,ko01100,map00280,map01100 - R05066 RC00099 ko00000,ko00001,ko01000 - - - NAD_binding_11,NAD_binding_2 k59_1172529_2 1267533.KB906735_gene4495 1.38e-16 80.1 COG0579@1|root,COG0579@2|Bacteria,3Y6NN@57723|Acidobacteria 57723|Acidobacteria S FAD dependent oxidoreductase - - - ko:K15736 - - - - ko00000,ko01000 - - - DAO k59_1338672_1 1229909.NSED_02935 1.64e-45 157.0 COG0517@1|root,arCOG00600@2157|Archaea,41TAT@651137|Thaumarchaeota 651137|Thaumarchaeota S CBS domain - - - - - - - - - - - - CBS k59_1228370_1 1122137.AQXF01000003_gene2417 9.97e-44 161.0 COG2234@1|root,COG2234@2|Bacteria,1NVWC@1224|Proteobacteria 1224|Proteobacteria S Peptidase family M28 - - - - - - - - - - - - Peptidase_M28 k59_211840_1 247634.GPB2148_659 1.09e-99 292.0 COG0500@1|root,COG2226@2|Bacteria,1MVSY@1224|Proteobacteria,1S24V@1236|Gammaproteobacteria 1236|Gammaproteobacteria Q Methionine biosynthesis protein MetW metW - - - - - - - - - - - MetW k59_722736_1 1207055.C100_11430 1.46e-129 376.0 COG0346@1|root,COG0346@2|Bacteria,1MUBT@1224|Proteobacteria,2VG62@28211|Alphaproteobacteria,2K1PT@204457|Sphingomonadales 204457|Sphingomonadales E Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - - - - - - - - - - Glyoxalase k59_491240_1 338966.Ppro_2780 2.87e-40 152.0 COG0068@1|root,COG0068@2|Bacteria,1MVP8@1224|Proteobacteria,42M3G@68525|delta/epsilon subdivisions,2WJ51@28221|Deltaproteobacteria,43S2B@69541|Desulfuromonadales 28221|Deltaproteobacteria O Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide hypF - - ko:K04656 - - - - ko00000 - - iAF987.Gmet_0119 Acylphosphatase,Sua5_yciO_yrdC,zf-HYPF k59_1282298_1 436308.Nmar_1624 9.87e-93 272.0 COG2238@1|root,arCOG01344@2157|Archaea,41SK1@651137|Thaumarchaeota 651137|Thaumarchaeota J May be involved in maturation of the 30S ribosomal subunit rps19e - - ko:K02966 ko03010,map03010 M00177,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S19e k59_1282298_2 1229909.NSED_08785 1.62e-27 102.0 COG2118@1|root,arCOG04179@2157|Archaea,41SR0@651137|Thaumarchaeota 651137|Thaumarchaeota S Belongs to the PDCD5 family - - - ko:K06875 - - - - ko00000 - - - dsDNA_bind k59_943619_1 1032480.MLP_48800 6.74e-27 106.0 COG1216@1|root,COG1216@2|Bacteria,2IDQX@201174|Actinobacteria 201174|Actinobacteria S Glycosyl transferase family 2 - - - - - - - - - - - - Glycos_transf_2 k59_943619_2 1282362.AEAC466_18780 0.00018 49.3 COG0457@1|root,COG0457@2|Bacteria,1R3PU@1224|Proteobacteria,2U3HS@28211|Alphaproteobacteria,2KHKE@204458|Caulobacterales 204458|Caulobacterales S Sulfotransferase domain - - - - - - - - - - - - Sulfotransfer_3,TPR_16 k59_1282301_1 1394178.AWOO02000007_gene3126 2.19e-30 122.0 COG0143@1|root,COG0143@2|Bacteria,2GK4S@201174|Actinobacteria,4EGSP@85012|Streptosporangiales 201174|Actinobacteria J tRNA synthetases class I (M) - - 6.1.1.10 ko:K01874 ko00450,ko00970,map00450,map00970 M00359,M00360 R03659,R04773 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_1g k59_1401324_1 1177154.Y5S_01480 4.54e-05 45.8 COG1664@1|root,COG1664@2|Bacteria,1PDPX@1224|Proteobacteria,1S9XY@1236|Gammaproteobacteria,1XMF1@135619|Oceanospirillales 135619|Oceanospirillales M COG1664 Integral membrane protein CcmA involved in cell shape determination - - - - - - - - - - - - Bactofilin k59_1401324_2 1122194.AUHU01000016_gene1835 4.16e-26 107.0 2DA4I@1|root,32TUN@2|Bacteria,1N0WK@1224|Proteobacteria,1S6HI@1236|Gammaproteobacteria,467DY@72275|Alteromonadaceae 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_832246_1 886882.PPSC2_c0964 6.24e-70 220.0 COG0084@1|root,COG0084@2|Bacteria,1TQRF@1239|Firmicutes,4HDI4@91061|Bacilli,26S6T@186822|Paenibacillaceae 91061|Bacilli L TatD related DNase mttC - - ko:K03424 - - - - ko00000,ko01000 - - - TatD_DNase k59_100081_1 112098.XP_008614378.1 8.54e-09 62.0 COG1084@1|root,KOG1490@2759|Eukaryota 2759|Eukaryota EGP negative regulation of collagen binding GTPBP4 GO:0000079,GO:0000166,GO:0000226,GO:0000278,GO:0000280,GO:0000463,GO:0000470,GO:0001882,GO:0001883,GO:0001932,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005635,GO:0005730,GO:0005737,GO:0005794,GO:0005829,GO:0006139,GO:0006275,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0006996,GO:0007010,GO:0007017,GO:0007049,GO:0007051,GO:0007052,GO:0007162,GO:0007275,GO:0007568,GO:0008150,GO:0008152,GO:0008156,GO:0008285,GO:0008340,GO:0009889,GO:0009890,GO:0009892,GO:0009966,GO:0009987,GO:0010259,GO:0010467,GO:0010556,GO:0010558,GO:0010605,GO:0010646,GO:0010883,GO:0010888,GO:0012505,GO:0016020,GO:0016043,GO:0016070,GO:0016072,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019219,GO:0019220,GO:0019222,GO:0022402,GO:0022407,GO:0022408,GO:0022607,GO:0022613,GO:0023051,GO:0030155,GO:0030334,GO:0030336,GO:0031090,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031396,GO:0031397,GO:0031399,GO:0031400,GO:0031647,GO:0031965,GO:0031967,GO:0031974,GO:0031975,GO:0031981,GO:0032268,GO:0032269,GO:0032501,GO:0032502,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0032879,GO:0033341,GO:0033342,GO:0034470,GO:0034641,GO:0034660,GO:0035639,GO:0036094,GO:0040012,GO:0040013,GO:0042127,GO:0042254,GO:0042273,GO:0042325,GO:0043167,GO:0043168,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043549,GO:0044085,GO:0044092,GO:0044237,GO:0044238,GO:0044422,GO:0044424,GO:0044428,GO:0044444,GO:0044446,GO:0044464,GO:0045859,GO:0045934,GO:0046483,GO:0046626,GO:0048285,GO:0048471,GO:0048519,GO:0048523,GO:0048583,GO:0048856,GO:0050789,GO:0050790,GO:0050793,GO:0050794,GO:0050821,GO:0051052,GO:0051053,GO:0051098,GO:0051100,GO:0051171,GO:0051172,GO:0051174,GO:0051225,GO:0051239,GO:0051246,GO:0051248,GO:0051270,GO:0051271,GO:0051338,GO:0051726,GO:0060255,GO:0065007,GO:0065008,GO:0065009,GO:0070013,GO:0070925,GO:0071704,GO:0071840,GO:0071900,GO:0080090,GO:0090304,GO:0090307,GO:0097159,GO:0097367,GO:0140014,GO:1900076,GO:1901265,GO:1901360,GO:1901363,GO:1902850,GO:1903047,GO:1903104,GO:1903320,GO:1903321,GO:1904029,GO:1905952,GO:1905953,GO:2000026,GO:2000112,GO:2000113,GO:2000145,GO:2000146,GO:2000241 2.1.1.313 ko:K06943,ko:K11269,ko:K19307 ko03008,map03008 - - - ko00000,ko00001,ko01000,ko03009,ko03036 - - - MMR_HSR1,NOG1,NOGCT k59_722744_1 247634.GPB2148_2171 1.35e-76 262.0 COG4773@1|root,COG4773@2|Bacteria,1QTXJ@1224|Proteobacteria,1T2K9@1236|Gammaproteobacteria,1JC13@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M COG1629 Outer membrane receptor proteins, mostly Fe transport - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_722744_2 95619.PM1_0207915 2.59e-76 242.0 COG3384@1|root,COG3384@2|Bacteria,1MW77@1224|Proteobacteria,1RQIK@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Extradiol catechol dioxygenase that catalyzes the oxidative cleavage of substituted catechols ligB GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0006082,GO:0006725,GO:0008150,GO:0008152,GO:0008198,GO:0009056,GO:0009987,GO:0016054,GO:0016491,GO:0016701,GO:0016702,GO:0017144,GO:0018918,GO:0018958,GO:0019336,GO:0019396,GO:0019439,GO:0019752,GO:0032787,GO:0036238,GO:0042537,GO:0042737,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0046872,GO:0046914,GO:0051213,GO:0055114,GO:0071704,GO:0072329,GO:1901360,GO:1901361,GO:1901575,GO:1901615,GO:1901616 1.13.11.57,1.13.11.8 ko:K04099,ko:K04101 ko00362,ko00624,ko00627,ko01120,map00362,map00624,map00627,map01120 - R01632,R03550,R04280,R09565 RC00233,RC00387,RC00535,RC02567,RC02694 br01602,ko00000,ko00001,ko01000 - - iJN746.PP_2518 LigA,LigB k59_661840_2 794903.OPIT5_14920 2.21e-31 120.0 COG1947@1|root,COG1947@2|Bacteria,46SV6@74201|Verrucomicrobia,3K807@414999|Opitutae 414999|Opitutae F Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol ispE - 2.7.1.148 ko:K00919 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05634 RC00002,RC01439 ko00000,ko00001,ko00002,ko01000 - - - GHMP_kinases_C,GHMP_kinases_N k59_1338694_1 316407.85676561 1.07e-220 653.0 COG3209@1|root,COG3209@2|Bacteria,1MVV1@1224|Proteobacteria,1SKYM@1236|Gammaproteobacteria,3XQSX@561|Escherichia 1236|Gammaproteobacteria M Rhs elements have a nonessential function. They may play an important role in the natural ecology of the cell rhsB GO:0006950,GO:0007154,GO:0008150,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0010438,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0042594,GO:0050896,GO:0051716,GO:0071496 - - - - - - - - - - DUF4329,RHS,RHS_repeat k59_1678859_1 702113.PP1Y_AT24591 5.75e-65 213.0 COG0608@1|root,COG0608@2|Bacteria,1MU1M@1224|Proteobacteria,2TRZQ@28211|Alphaproteobacteria,2K0VW@204457|Sphingomonadales 204457|Sphingomonadales L single-stranded-DNA-specific exonuclease RecJ recJ - - ko:K07462 ko03410,ko03430,ko03440,map03410,map03430,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DHH,DHHA1 k59_609318_1 1007104.SUS17_1700 3.6e-67 214.0 COG3386@1|root,COG3386@2|Bacteria,1MWTR@1224|Proteobacteria,2TV5X@28211|Alphaproteobacteria,2K16R@204457|Sphingomonadales 204457|Sphingomonadales G Gluconolactonase - - - ko:K14274 ko00040,map00040 - R02427 RC00713 ko00000,ko00001,ko01000 - - - SGL k59_1623935_1 1122137.AQXF01000003_gene2095 1.37e-18 80.9 COG0454@1|root,COG0456@2|Bacteria,1N581@1224|Proteobacteria,2UCR5@28211|Alphaproteobacteria 28211|Alphaproteobacteria K Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_1 k59_1623935_2 1122137.AQXF01000003_gene2096 1.71e-83 255.0 COG3246@1|root,COG3246@2|Bacteria,1MZTP@1224|Proteobacteria,2TQKN@28211|Alphaproteobacteria 28211|Alphaproteobacteria S PFAM Prokaryotic protein of - - - - - - - - - - - - BKACE k59_327712_1 1168065.DOK_12511 1.8e-29 115.0 COG1028@1|root,COG1028@2|Bacteria,1MXNQ@1224|Proteobacteria,1RRVQ@1236|Gammaproteobacteria 1236|Gammaproteobacteria IQ Belongs to the short-chain dehydrogenases reductases (SDR) family - - - - - - - - - - - - adh_short k59_1452255_1 1229909.NSED_00030 5.69e-97 308.0 COG1615@1|root,arCOG06128@2157|Archaea,41SCS@651137|Thaumarchaeota 651137|Thaumarchaeota S Uncharacterised protein family (UPF0182) - - - ko:K09118 - - - - ko00000 - - - UPF0182 k59_44205_2 1122194.AUHU01000002_gene2736 2.31e-76 242.0 COG0544@1|root,COG0544@2|Bacteria,1MUJP@1224|Proteobacteria,1RNZE@1236|Gammaproteobacteria,46543@72275|Alteromonadaceae 1236|Gammaproteobacteria D Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase tig GO:0000413,GO:0003674,GO:0003755,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0006464,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0016853,GO:0016859,GO:0018193,GO:0018208,GO:0019538,GO:0036211,GO:0042802,GO:0043021,GO:0043022,GO:0043170,GO:0043335,GO:0043412,GO:0044183,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0050896,GO:0051083,GO:0061077,GO:0071704,GO:0140096,GO:1901564 - ko:K03545 - - - - ko00000 - - - FKBP_C,Trigger_C,Trigger_N k59_1338710_1 555793.WSK_0929 1.86e-35 129.0 COG0725@1|root,COG0725@2|Bacteria,1MVNA@1224|Proteobacteria,2U5B1@28211|Alphaproteobacteria,2K17W@204457|Sphingomonadales 204457|Sphingomonadales P Molybdenum ABC transporter modA - - ko:K02020 ko02010,map02010 M00189 - - ko00000,ko00001,ko00002,ko02000 3.A.1.8 - - SBP_bac_11 k59_546712_1 1227499.C493_06777 3.03e-08 56.2 arCOG01792@1|root,arCOG01792@2157|Archaea,2XWRG@28890|Euryarchaeota,23VI0@183963|Halobacteria 183963|Halobacteria Q Methylase involved in ubiquinone menaquinone biosynthesis - - - - - - - - - - - - Methyltransf_25 k59_546712_2 1298864.AUEQ01000007_gene2114 5.66e-16 77.0 COG2020@1|root,COG2020@2|Bacteria,2I4HM@201174|Actinobacteria,23314@1762|Mycobacteriaceae 201174|Actinobacteria O PFAM Isoprenylcysteine carboxyl methyltransferase - - - - - - - - - - - - ICMT,PEMT k59_661865_2 1122135.KB893135_gene934 1.93e-30 118.0 COG2375@1|root,COG2375@2|Bacteria,1R4TD@1224|Proteobacteria,2U6TC@28211|Alphaproteobacteria 28211|Alphaproteobacteria P Siderophore-interacting protein - - - - - - - - - - - - FAD_binding_9,SIP k59_1113531_1 1123060.JONP01000001_gene1375 9.47e-44 162.0 COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,2TQMW@28211|Alphaproteobacteria,2JQY7@204441|Rhodospirillales 204441|Rhodospirillales C Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain - - 1.2.5.3 ko:K03520 - - R11168 RC02800 ko00000,ko01000 - - - Ald_Xan_dh_C,Ald_Xan_dh_C2 k59_832286_1 199310.c0153 6.63e-187 539.0 COG4993@1|root,COG4993@2|Bacteria,1MUQX@1224|Proteobacteria,1RN5D@1236|Gammaproteobacteria,3XPH2@561|Escherichia 1236|Gammaproteobacteria G Glucose dehydrogenase gcd GO:0000287,GO:0003674,GO:0003824,GO:0004344,GO:0005488,GO:0005575,GO:0008150,GO:0008152,GO:0008876,GO:0016020,GO:0016021,GO:0016491,GO:0016614,GO:0016901,GO:0019842,GO:0031224,GO:0031406,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0044425,GO:0046872,GO:0048037,GO:0048038,GO:0048039,GO:0055114,GO:0070968,GO:0097159,GO:1901363 1.1.5.2 ko:K00117 ko00030,ko01100,ko01110,ko01130,map00030,map01100,map01110,map01130 - R06620 RC00066 ko00000,ko00001,ko01000 - - iEC55989_1330.EC55989_0117,iECIAI1_1343.ECIAI1_0122,iECW_1372.ECW_m0121,iEKO11_1354.EKO11_3792,iWFL_1372.ECW_m0121 PQQ k59_154725_1 377629.TERTU_1412 1.63e-85 261.0 COG4974@1|root,COG4974@2|Bacteria,1NY1A@1224|Proteobacteria,1RN33@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Transposase - - - ko:K07484 - - - - ko00000 - - - DDE_Tnp_IS66,DDE_Tnp_IS66_C,LZ_Tnp_IS66,zf-IS66 k59_661871_1 243233.MCA0403 7.31e-19 83.6 COG0526@1|root,COG0526@2|Bacteria,1RHPC@1224|Proteobacteria,1S4C9@1236|Gammaproteobacteria,1XGQW@135618|Methylococcales 135618|Methylococcales O Thioredoxin-like - - - - - - - - - - - - AhpC-TSA k59_661871_2 69042.WH5701_03679 9.55e-11 61.6 COG0604@1|root,COG0604@2|Bacteria,1G0N4@1117|Cyanobacteria,1H0MV@1129|Synechococcus 1117|Cyanobacteria C NADPH quinone reductase - - 1.6.5.5 ko:K00344 - - - - ko00000,ko01000 - - - ADH_N,ADH_zinc_N_2 k59_384371_1 543728.Vapar_4045 2.26e-21 93.6 COG0477@1|root,COG0477@2|Bacteria,1MU46@1224|Proteobacteria,2VJXD@28216|Betaproteobacteria,4AABA@80864|Comamonadaceae 28216|Betaproteobacteria EGP Major facilitator superfamily - - - - - - - - - - - - MFS_1,Sugar_tr k59_384371_2 1532558.JL39_02780 3.4e-09 58.2 COG1622@1|root,COG1622@2|Bacteria,1MWHZ@1224|Proteobacteria,2U0IR@28211|Alphaproteobacteria,4BBM2@82115|Rhizobiaceae 28211|Alphaproteobacteria C ubiquinol oxidase subunit cyoA - 1.10.3.10 ko:K02297 ko00190,ko01100,map00190,map01100 M00417 R11335 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.4.5 - - COX2,COX_ARM k59_546730_1 1229909.NSED_08170 4.85e-101 296.0 arCOG08638@1|root,arCOG08638@2157|Archaea,41T08@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_546730_2 1229909.NSED_08175 1.64e-13 67.4 arCOG08639@1|root,arCOG08639@2157|Archaea,41SP8@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_435470_1 1121912.AUHD01000006_gene1252 1.45e-134 413.0 COG0060@1|root,COG0060@2|Bacteria,4NEYT@976|Bacteroidetes,1HX3Y@117743|Flavobacteriia 976|Bacteroidetes J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) ileS GO:0003674,GO:0003824,GO:0004812,GO:0004822,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006428,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.5 ko:K01870 ko00970,map00970 M00359,M00360 R03656 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,tRNA-synt_1 k59_1282366_1 983544.Lacal_0523 2.51e-36 128.0 2C52N@1|root,2Z7U1@2|Bacteria,4NEZW@976|Bacteroidetes,1HXZH@117743|Flavobacteriia 976|Bacteroidetes S porT protein porT - - - - - - - - - - - OMP_b-brl_2 k59_1282366_2 1492737.FEM08_29370 1.23e-45 154.0 COG0566@1|root,COG0566@2|Bacteria,4NG1U@976|Bacteroidetes,1HY9B@117743|Flavobacteriia,2NS92@237|Flavobacterium 976|Bacteroidetes J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family aviRb - - ko:K03437 - - - - ko00000,ko03016 - - - SpoU_methylase,SpoU_sub_bind k59_269603_1 1122137.AQXF01000001_gene2733 1.88e-47 163.0 COG2133@1|root,COG2133@2|Bacteria,1MVK5@1224|Proteobacteria,2TRN9@28211|Alphaproteobacteria 28211|Alphaproteobacteria G glucose sorbosone - - - - - - - - - - - - Cytochrome_CBB3,GSDH k59_269603_2 525373.HMPREF0766_13259 2.23e-15 79.0 COG2010@1|root,COG2133@1|root,COG2010@2|Bacteria,COG2133@2|Bacteria,4NH6T@976|Bacteroidetes,1IVA9@117747|Sphingobacteriia 976|Bacteroidetes C Glucose / Sorbosone dehydrogenase - - - ko:K21430 - - - - ko00000,ko01000 - - - Cytochrome_CBB3,GSDH k59_269603_3 1122137.AQXF01000001_gene2731 3.34e-86 279.0 COG4206@1|root,COG4206@2|Bacteria,1R1WX@1224|Proteobacteria,2U0GK@28211|Alphaproteobacteria 28211|Alphaproteobacteria H receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_211906_1 335659.S23_05030 2.5e-18 89.4 COG0840@1|root,COG2770@1|root,COG0840@2|Bacteria,COG2770@2|Bacteria,1MU9B@1224|Proteobacteria,2TQR7@28211|Alphaproteobacteria,3JSI9@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria NT chemotaxis MA20_39440 - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - HAMP,MCPsignal k59_892722_1 68886.XP_009692697.1 4.83e-13 68.6 COG0445@1|root,KOG2311@2759|Eukaryota,3YBAV@5794|Apicomplexa,3KADH@422676|Aconoidasida,3Z4AI@5863|Piroplasmida 422676|Aconoidasida J division protein - - - ko:K03495 - - R08701 RC00053,RC00209,RC00870 ko00000,ko03016,ko03036 - - - GIDA,GIDA_assoc k59_1401393_1 1234364.AMSF01000030_gene3413 1.74e-63 213.0 COG0204@1|root,COG0204@2|Bacteria,1MWDY@1224|Proteobacteria,1RRXF@1236|Gammaproteobacteria,1X3Z7@135614|Xanthomonadales 135614|Xanthomonadales I Acyltransferase aas - - - - - - - - - - - Acyltransferase,MFS_1 k59_999612_1 585394.RHOM_11605 8.31e-28 114.0 COG0443@1|root,COG0443@2|Bacteria,1TQ6N@1239|Firmicutes,248UV@186801|Clostridia 186801|Clostridia O Belongs to the heat shock protein 70 family - - - ko:K04045 - - - - ko00000,ko03110 1.A.33 - - HSP70 k59_943688_1 1336233.JAEH01000025_gene1084 1.06e-44 155.0 COG1561@1|root,COG1561@2|Bacteria,1MWRA@1224|Proteobacteria,1RMAB@1236|Gammaproteobacteria,2QAEN@267890|Shewanellaceae 1236|Gammaproteobacteria S PFAM YicC N-terminal domain protein yicC GO:0000175,GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004532,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008408,GO:0009022,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016072,GO:0016075,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016796,GO:0016896,GO:0019439,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0140098,GO:0140101,GO:1901360,GO:1901361,GO:1901575 - - - - - - - - - - DUF1732,YicC_N k59_892732_1 158500.BV97_01295 1.03e-141 422.0 COG3119@1|root,COG3119@2|Bacteria,1MV92@1224|Proteobacteria,2TTXG@28211|Alphaproteobacteria 28211|Alphaproteobacteria P Arylsulfatase - - 3.1.6.1 ko:K01130 ko00140,ko00600,map00140,map00600 - R03980,R04856 RC00128,RC00231 ko00000,ko00001,ko01000 - - - Sulfatase k59_491325_1 436308.Nmar_1259 1.85e-98 299.0 COG2132@1|root,arCOG03914@2157|Archaea,41SZT@651137|Thaumarchaeota 651137|Thaumarchaeota Q Multicopper oxidase - - 1.7.2.1 ko:K00368 ko00910,ko01120,map00910,map01120 M00529 R00783,R00785 RC00086 ko00000,ko00001,ko00002,ko01000 - - - Cu-oxidase_3 k59_1228434_2 1229909.NSED_09425 4.77e-159 451.0 COG3794@1|root,arCOG08795@1|root,arCOG02926@2157|Archaea,arCOG08795@2157|Archaea 2157|Archaea C copper ion binding - - - - - - - - - - - - Copper-bind,Cu-oxidase_2,Cu-oxidase_3,Cupredoxin_1 k59_491326_1 1121374.KB891586_gene2673 7.52e-64 213.0 COG1574@1|root,COG1574@2|Bacteria,1MWP2@1224|Proteobacteria,1RNB7@1236|Gammaproteobacteria 1236|Gammaproteobacteria S metal-dependent hydrolase with the TIM-barrel fold - - - - - - - - - - - - Amidohydro_3 k59_1571408_1 1049564.TevJSym_aa00100 1.57e-12 62.0 COG0255@1|root,COG0255@2|Bacteria,1N6PR@1224|Proteobacteria,1SCBN@1236|Gammaproteobacteria,1J6WB@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Belongs to the universal ribosomal protein uL29 family rpmC GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02904 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L29 k59_1571408_2 270374.MELB17_20171 7.11e-73 221.0 COG0197@1|root,COG0197@2|Bacteria,1RA0Z@1224|Proteobacteria,1S201@1236|Gammaproteobacteria,466H8@72275|Alteromonadaceae 1236|Gammaproteobacteria J Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs rplP GO:0000027,GO:0000049,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02878 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L16 k59_1060737_1 1144305.PMI02_03411 2.85e-09 59.7 COG4774@1|root,COG4774@2|Bacteria,1QURD@1224|Proteobacteria,2TWX2@28211|Alphaproteobacteria,2K975@204457|Sphingomonadales 204457|Sphingomonadales P TonB dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_610338_1 926569.ANT_07770 6.39e-90 271.0 COG0171@1|root,COG0171@2|Bacteria,2G6X3@200795|Chloroflexi 200795|Chloroflexi H NAD synthase - - 6.3.1.5 ko:K01916 ko00760,ko01100,map00760,map01100 M00115 R00189 RC00100 ko00000,ko00001,ko00002,ko01000 - - - NAD_synthase k59_1173289_1 1535287.JP74_08415 2.47e-58 182.0 COG1917@1|root,COG1917@2|Bacteria,1MYNN@1224|Proteobacteria,2UAVB@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Cupin 2, conserved barrel domain protein - - - - - - - - - - - - Cupin_7 k59_1680028_1 1469557.JSWF01000016_gene2170 5.69e-69 229.0 COG1305@1|root,COG1305@2|Bacteria,4NEKT@976|Bacteroidetes,1HYKS@117743|Flavobacteriia 976|Bacteroidetes E Domain of Unknown Function with PDB structure (DUF3857) - - - - - - - - - - - - DUF3857,Transglut_core k59_1624976_1 349521.HCH_06842 2.98e-26 100.0 COG2193@1|root,COG2193@2|Bacteria,1RCW7@1224|Proteobacteria,1S45S@1236|Gammaproteobacteria,1XJM8@135619|Oceanospirillales 135619|Oceanospirillales P Iron-storage protein, whose ferroxidase center binds Fe(2 ) ions, oxidizes them by dioxygen to Fe(3 ), and participates in the subsequent Fe(3 ) oxide mineral core formation within the central cavity of the protein complex bfr - 1.16.3.1 ko:K03594 ko00860,map00860 - R00078 RC02758 ko00000,ko00001,ko01000 - - - Ferritin k59_1122991_2 1096930.L284_01840 2.66e-28 107.0 COG2197@1|root,COG2197@2|Bacteria 2|Bacteria K response regulator - - - ko:K02282,ko:K07782,ko:K19135 ko02020,ko02024,ko02026,map02020,map02024,map02026 - - - ko00000,ko00001,ko02035,ko02044,ko02048,ko03000 - - - Cas_NE0113,GerE,PAS_3,Response_reg,TPR_16 k59_1523377_1 648757.Rvan_1444 6.15e-45 155.0 COG3440@1|root,COG3440@2|Bacteria,1N4JP@1224|Proteobacteria,2TS2Z@28211|Alphaproteobacteria 28211|Alphaproteobacteria L restriction endonuclease - - - - - - - - - - - - HNH_2 k59_1181731_1 1122137.AQXF01000004_gene1699 4.36e-115 344.0 COG0642@1|root,COG0642@2|Bacteria,1QYPP@1224|Proteobacteria,2TXUU@28211|Alphaproteobacteria 28211|Alphaproteobacteria T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c k59_619360_1 404589.Anae109_1032 1.51e-54 194.0 COG4262@1|root,COG4262@2|Bacteria 2|Bacteria H Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine - - 2.5.1.16 ko:K00797 ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100 M00034,M00133 R01920,R02869,R08359 RC00021,RC00053 ko00000,ko00001,ko00002,ko01000 - - - MFS_1,Spermine_synth k59_1462070_1 1348657.M622_10390 1.85e-14 73.2 COG0525@1|root,COG0525@2|Bacteria,1MV7B@1224|Proteobacteria,2VH5Z@28216|Betaproteobacteria,2KVPX@206389|Rhodocyclales 206389|Rhodocyclales J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner valS - 6.1.1.9 ko:K01873 ko00970,map00970 M00359,M00360 R03665 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1 k59_1462070_2 1541065.JRFE01000001_gene2607 5.61e-19 88.6 COG0477@1|root,COG2814@2|Bacteria,1G2N2@1117|Cyanobacteria,3VMM0@52604|Pleurocapsales 1117|Cyanobacteria EGP Transmembrane secretion effector - - - - - - - - - - - - MFS_1,MFS_3 k59_1123001_1 408672.NBCG_00420 2.51e-31 116.0 COG3665@1|root,COG3665@2|Bacteria,2GKI6@201174|Actinobacteria,4DUBU@85009|Propionibacteriales 201174|Actinobacteria S Domain of unknown function (DUF1989) - - - ko:K09967 - - - - ko00000 - - - DUF1989 k59_1123001_2 583355.Caka_2069 2.39e-45 165.0 COG0439@1|root,COG1984@1|root,COG2049@1|root,COG0439@2|Bacteria,COG1984@2|Bacteria,COG2049@2|Bacteria,46U8Z@74201|Verrucomicrobia,3K95E@414999|Opitutae 414999|Opitutae EI Pfam:AHS1 - - 6.3.4.6 ko:K01941 ko00220,ko00791,ko01100,map00220,map00791,map01100 - R00774 RC00378 ko00000,ko00001,ko01000 - - - Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2,CT_A_B,CT_C_D k59_53826_1 1550073.JROH01000065_gene2792 6.52e-09 58.2 COG5534@1|root,COG5534@2|Bacteria,1MXQ0@1224|Proteobacteria,2TRBV@28211|Alphaproteobacteria,2K01D@204457|Sphingomonadales 204457|Sphingomonadales L Replication initiator protein A - - - - - - - - - - - - RPA k59_53826_2 1088721.NSU_1083 4.88e-215 597.0 COG1087@1|root,COG1087@2|Bacteria,1MUHI@1224|Proteobacteria,2TTC7@28211|Alphaproteobacteria,2K1G3@204457|Sphingomonadales 204457|Sphingomonadales M Belongs to the NAD(P)-dependent epimerase dehydratase family galE - 5.1.3.2 ko:K01784 ko00052,ko00520,ko01100,map00052,map00520,map01100 M00361,M00362,M00632 R00291,R02984 RC00289 ko00000,ko00001,ko00002,ko01000 - - - Epimerase k59_1745951_2 563192.HMPREF0179_02242 1.73e-57 186.0 COG0479@1|root,COG0479@2|Bacteria,1MVHS@1224|Proteobacteria,42M2J@68525|delta/epsilon subdivisions,2WJMH@28221|Deltaproteobacteria,2M84J@213115|Desulfovibrionales 28221|Deltaproteobacteria C TIGRFAM succinate dehydrogenase and fumarate reductase iron-sulfur protein sdhB - 1.3.5.1,1.3.5.4 ko:K00240,ko:K00245 ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020 M00009,M00011,M00149,M00150,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 - - - Fer2_3,Fer4_10,Fer4_8 k59_53845_1 1229781.C272_14333 3.34e-52 184.0 COG5505@1|root,COG5505@2|Bacteria,2ID34@201174|Actinobacteria,4F9KE@85019|Brevibacteriaceae 201174|Actinobacteria S Protein of unknown function (DUF819) - - - - - - - - - - - - DUF819 k59_782726_1 1122137.AQXF01000001_gene2874 9.29e-22 89.0 COG0684@1|root,COG0684@2|Bacteria,1RH18@1224|Proteobacteria,2UCWD@28211|Alphaproteobacteria 28211|Alphaproteobacteria H Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions rraA - - ko:K02553 - - - - ko00000,ko03019 - - - RraA-like k59_782726_2 1122137.AQXF01000001_gene2875 1.33e-37 126.0 2CFZF@1|root,331GH@2|Bacteria,1N7WZ@1224|Proteobacteria,2UIBT@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_782726_3 744980.TRICHSKD4_2192 1.19e-06 52.8 COG0500@1|root,COG2226@2|Bacteria,1NA7K@1224|Proteobacteria,2TT7T@28211|Alphaproteobacteria 28211|Alphaproteobacteria Q Methyltransferase MA20_39625 - - - - - - - - - - - Methyltransf_11 k59_53851_1 493475.GARC_4723 1.25e-218 613.0 COG2124@1|root,COG2124@2|Bacteria,1MV8Q@1224|Proteobacteria,1RPW8@1236|Gammaproteobacteria,46AJA@72275|Alteromonadaceae 1236|Gammaproteobacteria Q Cytochrome P450 ahpG - - - - - - - - - - - p450 k59_53851_2 279238.Saro_2609 2.05e-126 374.0 COG0174@1|root,COG0174@2|Bacteria,1MU6V@1224|Proteobacteria,2U0Z2@28211|Alphaproteobacteria,2KCZZ@204457|Sphingomonadales 204457|Sphingomonadales E Glutamine synthetase, catalytic domain - - 6.3.1.2 ko:K01915 ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 - R00253 RC00010,RC02798 ko00000,ko00001,ko01000,ko04147 - - - Gln-synt_C k59_1523440_1 1229909.NSED_03880 8.7e-50 165.0 COG0640@1|root,arCOG03622@1|root,arCOG01686@2157|Archaea,arCOG03622@2157|Archaea 2157|Archaea K regulatory protein, arsR - - - - - - - - - - - - HTH_20 k59_394194_1 930169.B5T_02619 3.82e-12 66.2 COG0501@1|root,COG0501@2|Bacteria,1MUV4@1224|Proteobacteria,1RMN0@1236|Gammaproteobacteria,1XHG2@135619|Oceanospirillales 135619|Oceanospirillales O Belongs to the peptidase M48B family htpX - - ko:K03799 - M00743 - - ko00000,ko00002,ko01000,ko01002 - - - Peptidase_M48 k59_394194_2 1380394.JADL01000011_gene3905 9.3e-35 131.0 COG2303@1|root,COG2303@2|Bacteria,1MV19@1224|Proteobacteria,2TQKQ@28211|Alphaproteobacteria,2JPPV@204441|Rhodospirillales 204441|Rhodospirillales E Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate - - - - - - - - - - - - GMC_oxred_C,GMC_oxred_N k59_842252_1 1122137.AQXF01000002_gene613 5.97e-163 480.0 COG0308@1|root,COG0308@2|Bacteria,1MUV3@1224|Proteobacteria,2TVKQ@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Peptidase family M1 domain - - - - - - - - - - - - Peptidase_M1 k59_556219_1 1144305.PMI02_03182 5.01e-29 114.0 COG2149@1|root,COG2149@2|Bacteria,1N9QP@1224|Proteobacteria,2UNPS@28211|Alphaproteobacteria,2KB23@204457|Sphingomonadales 204457|Sphingomonadales S membrane - - - - - - - - - - - - DUF202 k59_1181750_1 1123073.KB899243_gene664 2.52e-56 190.0 COG0534@1|root,COG0534@2|Bacteria,1MVRV@1224|Proteobacteria,1RRDQ@1236|Gammaproteobacteria,1X4AT@135614|Xanthomonadales 135614|Xanthomonadales V MatE - - - - - - - - - - - - MatE k59_1181750_2 484770.UFO1_1593 3.9e-51 178.0 COG1073@1|root,COG1073@2|Bacteria,1UQS2@1239|Firmicutes 1239|Firmicutes S alpha beta - - - - - - - - - - - - AXE1,Chlorophyllase2,Hydrolase_4,Peptidase_S15 k59_953281_1 1333856.L686_01140 2.02e-56 196.0 COG3071@1|root,COG3071@2|Bacteria,1MU7A@1224|Proteobacteria,1RMRG@1236|Gammaproteobacteria,1Z1ZU@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria H enzyme of heme biosynthesis hemY GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K02498 - - - - ko00000 - - - HemY_N,TPR_2 k59_445128_1 1174528.JH992892_gene6385 3.2e-12 71.6 COG0277@1|root,COG0277@2|Bacteria 2|Bacteria C FAD linked oxidase domain protein - - - - - - - - - - - - BBE,FAD_binding_4 k59_1292402_1 1122604.JONR01000007_gene2912 5.85e-65 214.0 COG1171@1|root,COG1171@2|Bacteria,1MVWJ@1224|Proteobacteria,1RMY6@1236|Gammaproteobacteria,1XCHU@135614|Xanthomonadales 135614|Xanthomonadales E Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA ilvA - 4.3.1.19 ko:K01754 ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230 M00570 R00220,R00996 RC00418,RC02600 ko00000,ko00001,ko00002,ko01000 - - - PALP,Thr_dehydrat_C k59_671291_1 204669.Acid345_0520 2.86e-35 139.0 COG0784@1|root,COG4191@1|root,COG0784@2|Bacteria,COG4191@2|Bacteria 2|Bacteria T Histidine kinase - - - - - - - - - - - - GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_9,Response_reg k59_1580988_1 1112216.JH594425_gene1793 4.09e-51 177.0 COG0492@1|root,COG1145@1|root,COG0492@2|Bacteria,COG1145@2|Bacteria,1PR9I@1224|Proteobacteria,2U1SM@28211|Alphaproteobacteria,2K253@204457|Sphingomonadales 204457|Sphingomonadales C 4Fe-4S binding domain - - - - - - - - - - - - Fer4,Fer4_4,Pyr_redox_3 k59_53898_2 1380391.JIAS01000011_gene4709 1.26e-64 210.0 COG0477@1|root,COG2814@2|Bacteria,1MWFH@1224|Proteobacteria,2TR0R@28211|Alphaproteobacteria,2JR1G@204441|Rhodospirillales 204441|Rhodospirillales EGP Major facilitator superfamily - - - - - - - - - - - - MFS_1 k59_1070136_1 861299.J421_1071 3.46e-36 136.0 COG0593@1|root,COG0593@2|Bacteria,1ZSQ2@142182|Gemmatimonadetes 142182|Gemmatimonadetes L it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids dnaA - - ko:K02313 ko02020,ko04112,map02020,map04112 - - - ko00000,ko00001,ko03032,ko03036 - - - Bac_DnaA,Bac_DnaA_C,DnaA_N k59_1181782_1 85643.Tmz1t_3378 2.43e-29 122.0 COG0557@1|root,COG0557@2|Bacteria,1MUS6@1224|Proteobacteria,2VHBJ@28216|Betaproteobacteria,2KUXR@206389|Rhodocyclales 206389|Rhodocyclales J 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs rnr - - ko:K12573 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03016,ko03019 - - - OB_RNB,RNB,S1 k59_1292415_1 439481.Aboo_0823 1.18e-39 140.0 COG0708@1|root,arCOG02207@2157|Archaea,2XVJ5@28890|Euryarchaeota,3F351@33867|unclassified Euryarchaeota 28890|Euryarchaeota L PFAM Endonuclease Exonuclease phosphatase exoA - 3.1.11.2 ko:K01142 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - Exo_endo_phos k59_1292415_2 1265505.ATUG01000002_gene1288 6.9e-53 178.0 COG2188@1|root,COG2188@2|Bacteria,1MUEB@1224|Proteobacteria,42QNG@68525|delta/epsilon subdivisions,2WK8B@28221|Deltaproteobacteria,2MJ8V@213118|Desulfobacterales 28221|Deltaproteobacteria K UTRA domain - - - ko:K03710 - - - - ko00000,ko03000 - - - GntR,UTRA k59_1123063_1 1415778.JQMM01000001_gene1415 2.36e-79 244.0 COG0501@1|root,COG0501@2|Bacteria,1MUV4@1224|Proteobacteria,1RMN0@1236|Gammaproteobacteria,1J4K1@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O Belongs to the peptidase M48B family htpX GO:0003674,GO:0003824,GO:0004175,GO:0004222,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006508,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0008270,GO:0009266,GO:0009408,GO:0009628,GO:0016020,GO:0016021,GO:0016787,GO:0019538,GO:0031224,GO:0043167,GO:0043169,GO:0043170,GO:0044238,GO:0044425,GO:0044464,GO:0046872,GO:0046914,GO:0050896,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564 - ko:K03799 - M00743 - - ko00000,ko00002,ko01000,ko01002 - - - Peptidase_M48 k59_1581000_1 1485545.JQLW01000005_gene1190 8.19e-33 130.0 COG0739@1|root,COG4413@1|root,COG0739@2|Bacteria,COG4413@2|Bacteria,1MXH6@1224|Proteobacteria 1224|Proteobacteria M peptidase - - - - - - - - - - - - Peptidase_M23,UT k59_1411183_1 553385.JEMF01000040_gene2207 4.24e-110 346.0 COG0458@1|root,COG0458@2|Bacteria,1MUDZ@1224|Proteobacteria,1RPIU@1236|Gammaproteobacteria,1XHKH@135619|Oceanospirillales 135619|Oceanospirillales F Carbamoyl-phosphate synthetase ammonia chain carB - 6.3.5.5 ko:K01955 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - - CPSase_L_D2,CPSase_L_D3,MGS k59_953303_1 983920.Y88_2149 1.23e-49 177.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,2TQR7@28211|Alphaproteobacteria,2K0BV@204457|Sphingomonadales 204457|Sphingomonadales NT methyl-accepting chemotaxis protein - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - 4HB_MCP_1,HAMP,MCPsignal k59_1348467_1 757424.Hsero_1220 9.47e-97 289.0 COG0811@1|root,COG0811@2|Bacteria,1NCWW@1224|Proteobacteria,2VJPW@28216|Betaproteobacteria,47270@75682|Oxalobacteraceae 28216|Betaproteobacteria U MotA TolQ ExbB proton channel family tolQ - - ko:K03561,ko:K03562 ko01120,map01120 - - - ko00000,ko02000 1.A.30.2.1,1.A.30.2.2 - - MotA_ExbB k59_221445_1 945713.IALB_1946 4.39e-29 110.0 COG2128@1|root,COG2128@2|Bacteria 2|Bacteria S hydroperoxide reductase activity - - - - - - - - - - - - CMD k59_1123091_1 436308.Nmar_0719 1.25e-109 324.0 COG0601@1|root,arCOG00751@2157|Archaea,41S7B@651137|Thaumarchaeota 651137|Thaumarchaeota P inner membrane component - - - ko:K02033 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1 k59_732559_1 1121937.AUHJ01000011_gene2906 2.07e-61 202.0 COG2124@1|root,COG2124@2|Bacteria,1MV8Q@1224|Proteobacteria,1RPW8@1236|Gammaproteobacteria,465IF@72275|Alteromonadaceae 1236|Gammaproteobacteria Q cytochrome P450 - - 1.14.15.13 ko:K17474 - - - - ko00000,ko00199,ko01000 - - - FAD_binding_6,Fer2,p450 k59_902494_1 316407.85675179 5.64e-145 455.0 COG1388@1|root,COG1470@1|root,COG1388@2|Bacteria,COG1470@2|Bacteria,1MX9S@1224|Proteobacteria,1RPK7@1236|Gammaproteobacteria,3XN7T@561|Escherichia 1236|Gammaproteobacteria M cell adhesion yeeJ GO:0005575,GO:0005623,GO:0007155,GO:0008150,GO:0009279,GO:0009405,GO:0009987,GO:0016020,GO:0019867,GO:0022610,GO:0030260,GO:0030312,GO:0030313,GO:0031589,GO:0031975,GO:0042710,GO:0043708,GO:0044403,GO:0044409,GO:0044419,GO:0044462,GO:0044464,GO:0044764,GO:0051701,GO:0051704,GO:0051806,GO:0051828,GO:0071944,GO:0090605 - ko:K13735 ko05100,map05100 - - - ko00000,ko00001 - - - Big_1,Big_2,IAT_beta,Invasin_D3,LysM k59_1181813_1 345201.VF337_IIV3 3.32e-119 350.0 4QC93@10239|Viruses,4QVZB@35237|dsDNA viruses no RNA stage 10239|Viruses S Pfam:Pox_G9-A16 - - - - - - - - - - - - - k59_1798396_1 1028806.GGE_0367 3.11e-44 159.0 COG1726@1|root,COG1726@2|Bacteria,1MU36@1224|Proteobacteria,1RPU1@1236|Gammaproteobacteria,1Y79N@135625|Pasteurellales 135625|Pasteurellales C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol nqrA - 1.6.5.8 ko:K00346 - - - - ko00000,ko01000 - - - NQRA,NQRA_SLBB k59_671318_1 1125973.JNLC01000014_gene2414 7.52e-42 153.0 COG2267@1|root,COG2267@2|Bacteria,1QTZP@1224|Proteobacteria,2U1G2@28211|Alphaproteobacteria 28211|Alphaproteobacteria I Serine aminopeptidase, S33 - - - - - - - - - - - - Abhydrolase_6,Hydrolase_4 k59_1123101_1 998674.ATTE01000001_gene1329 3.61e-96 294.0 COG1012@1|root,COG1012@2|Bacteria,1MUHV@1224|Proteobacteria,1RNFN@1236|Gammaproteobacteria,4620W@72273|Thiotrichales 72273|Thiotrichales C Aldehyde dehydrogenase family - - 1.2.1.18,1.2.1.27 ko:K00140 ko00280,ko00410,ko00562,ko00640,ko01100,ko01200,map00280,map00410,map00562,map00640,map01100,map01200 M00013 R00705,R00706,R00922,R00935 RC00004,RC02723,RC02817 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_902498_1 382464.ABSI01000013_gene1670 9.42e-13 73.2 COG4191@1|root,COG4191@2|Bacteria,46TN7@74201|Verrucomicrobia,2IVI6@203494|Verrucomicrobiae 203494|Verrucomicrobiae T PAS fold - - - - - - - - - - - - HATPase_c,HisKA,PAS_9,Response_reg k59_902498_2 1238450.VIBNISOn1_300033 1.24e-51 169.0 2DBRK@1|root,2ZAME@2|Bacteria,1P1YU@1224|Proteobacteria,1S8J7@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_445175_1 1304877.KI519399_gene2903 4.32e-81 255.0 COG0154@1|root,COG0154@2|Bacteria,1MWRI@1224|Proteobacteria,2TTJU@28211|Alphaproteobacteria,3JVBW@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria J Amidase - - 6.3.5.6,6.3.5.7 ko:K02433 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - Amidase k59_1292475_1 1121382.JQKG01000004_gene3952 1.9e-50 174.0 COG0554@1|root,COG0554@2|Bacteria,1WI6Q@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus C Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate glpK - 2.7.1.30 ko:K00864 ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626 - R00847 RC00002,RC00017 ko00000,ko00001,ko01000,ko04147 - - - FGGY_C,FGGY_N k59_445179_1 1122164.JHWF01000004_gene4 1.77e-20 91.3 COG0475@1|root,COG0475@2|Bacteria,1RB9F@1224|Proteobacteria,1S398@1236|Gammaproteobacteria,1JDR9@118969|Legionellales 118969|Legionellales P Sodium/hydrogen exchanger family - - - - - - - - - - - - Na_H_Exchanger k59_445179_2 765911.Thivi_2691 7.75e-31 112.0 COG0375@1|root,COG0375@2|Bacteria,1MZJH@1224|Proteobacteria,1S5WG@1236|Gammaproteobacteria,1WYQN@135613|Chromatiales 135613|Chromatiales S Probably plays a role in a hydrogenase nickel cofactor insertion step hypA - - ko:K04651 - - - - ko00000,ko03110 - - - HypA k59_1237625_1 395965.Msil_3314 1.58e-52 175.0 COG1028@1|root,COG1028@2|Bacteria,1P9R4@1224|Proteobacteria,2TSIF@28211|Alphaproteobacteria,3NA8Q@45404|Beijerinckiaceae 28211|Alphaproteobacteria IQ NAD dependent epimerase/dehydratase family - - - - - - - - - - - - adh_short k59_337257_1 1205681.CALW02000074_gene1908 2.27e-07 48.1 2AEC3@1|root,3146K@2|Bacteria,1PTMR@1224|Proteobacteria,2V5H0@28211|Alphaproteobacteria,48UM1@772|Bartonellaceae 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_672351_2 436308.Nmar_0398 7.7e-80 239.0 COG0256@1|root,arCOG04088@2157|Archaea,41SQW@651137|Thaumarchaeota 651137|Thaumarchaeota J This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance rpl18 - - ko:K02881 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L5e k59_395282_1 864702.OsccyDRAFT_0260 5.98e-61 215.0 COG2931@1|root,COG3391@1|root,COG4222@1|root,COG2931@2|Bacteria,COG3391@2|Bacteria,COG4222@2|Bacteria,1G0YK@1117|Cyanobacteria,1H90W@1150|Oscillatoriales 1117|Cyanobacteria F phosphatase - - 3.1.3.8 ko:K01083,ko:K07004 ko00562,map00562 - R03371 RC00078 ko00000,ko00001,ko01000 - - - 5_nucleotid_C,Calx-beta,DUF4114,Exo_endo_phos,LTD,Phytase-like,VPEP k59_1182891_1 383381.EH30_11820 2.33e-106 324.0 COG0146@1|root,COG0146@2|Bacteria,1QU46@1224|Proteobacteria,2TVYU@28211|Alphaproteobacteria,2K11U@204457|Sphingomonadales 204457|Sphingomonadales EQ PFAM Hydantoinase B oxoprolinase - - 3.5.2.14 ko:K01474 ko00330,ko01100,map00330,map01100 - R03187 RC00632 ko00000,ko00001,ko01000 - - - Hydantoinase_B k59_222431_1 1133850.SHJG_3810 4.45e-05 50.8 COG0438@1|root,COG0438@2|Bacteria,2GMXE@201174|Actinobacteria 201174|Actinobacteria M Glycosyl transferase - - - - - - - - - - - - Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1 k59_1747015_1 1410620.SHLA_37c000680 4.24e-14 70.5 COG1177@1|root,COG1177@2|Bacteria,1MWVC@1224|Proteobacteria,2TV8E@28211|Alphaproteobacteria 28211|Alphaproteobacteria E COG1177 ABC-type spermidine putrescine transport system, permease component II - - - ko:K11070 ko02010,map02010 M00299 - - ko00000,ko00001,ko00002,ko02000 3.A.1.11.1 - - BPD_transp_1 k59_1747015_2 1410620.SHLA_37c000670 5.76e-73 226.0 COG1176@1|root,COG1176@2|Bacteria,1R4YI@1224|Proteobacteria,2TV12@28211|Alphaproteobacteria,4B8X1@82115|Rhizobiaceae 28211|Alphaproteobacteria E Binding-protein-dependent transport system inner membrane component - - - ko:K02054,ko:K11079 ko02010,ko02024,map02010,map02024 M00193,M00301 - - ko00000,ko00001,ko00002,ko02000 3.A.1.11,3.A.1.11.3 - - BPD_transp_1 k59_1690094_1 702113.PP1Y_AT4671 2.29e-55 182.0 COG1648@1|root,COG1648@2|Bacteria,1RFEE@1224|Proteobacteria,2U6CW@28211|Alphaproteobacteria,2K2V1@204457|Sphingomonadales 204457|Sphingomonadales H Siroheme synthase - - 1.3.1.76,2.1.1.107,4.99.1.4 ko:K02302 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R02864,R03194,R03947 RC00003,RC00871,RC01012,RC01034 ko00000,ko00001,ko00002,ko01000 - - - CysG_dimeriser,NAD_binding_7 k59_501285_1 1088721.NSU_2663 1.72e-62 202.0 2C3QV@1|root,2Z7YP@2|Bacteria,1MXAM@1224|Proteobacteria,2U1FE@28211|Alphaproteobacteria,2K063@204457|Sphingomonadales 204457|Sphingomonadales - - - - - - - - - - - - - - Alginate_exp k59_501285_2 224911.27351058 3.77e-13 67.8 COG2116@1|root,COG2116@2|Bacteria,1MU0W@1224|Proteobacteria,2TTIW@28211|Alphaproteobacteria,3JRBF@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria P Formate/nitrite transporter MA20_17080 - - - - - - - - - - - Form_Nir_trans k59_446187_1 1122137.AQXF01000002_gene237 5.05e-295 813.0 COG0143@1|root,COG0143@2|Bacteria,1MUBY@1224|Proteobacteria,2TQKA@28211|Alphaproteobacteria 28211|Alphaproteobacteria J Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation metG - 6.1.1.10 ko:K01874 ko00450,ko00970,map00450,map00970 M00359,M00360 R03659,R04773 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,tRNA-synt_1g k59_446187_2 395963.Bind_1535 3.27e-10 65.9 COG0470@1|root,COG0470@2|Bacteria,1MY1W@1224|Proteobacteria,2TV3E@28211|Alphaproteobacteria,3NAST@45404|Beijerinckiaceae 28211|Alphaproteobacteria L DNA polymerase III, delta subunit holB - 2.7.7.7 ko:K02341 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_delta2 k59_557197_1 158500.BV97_00800 3.8e-90 275.0 COG2030@1|root,COG2030@2|Bacteria,1NTV7@1224|Proteobacteria,2UQFU@28211|Alphaproteobacteria,2K8I3@204457|Sphingomonadales 204457|Sphingomonadales I N-terminal half of MaoC dehydratase - - - - - - - - - - - - MaoC_dehydrat_N k59_1524512_1 1123234.AUKI01000011_gene1109 5.32e-58 195.0 COG0513@1|root,COG0513@2|Bacteria,4NEVI@976|Bacteroidetes,1HZ6Y@117743|Flavobacteriia 976|Bacteroidetes L DEAD DEAH box helicase rhlE - 3.6.4.13 ko:K11927 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - DEAD,Helicase_C k59_557205_2 479432.Sros_0935 1.6e-81 268.0 COG5297@1|root,COG5297@2|Bacteria,2IAE1@201174|Actinobacteria,4EH2T@85012|Streptosporangiales 201174|Actinobacteria G Cellulose binding domain - - 3.2.1.11,3.2.1.4 ko:K01179,ko:K05988 ko00500,ko01100,map00500,map01100 - R06200,R11307,R11308,R11309 - ko00000,ko00001,ko01000 - GH5,GH66,GH9 - CBM_2,CBM_3,Glyco_hydro_9,fn3 k59_783714_1 1038859.AXAU01000015_gene937 8.23e-78 247.0 COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,2TR4Q@28211|Alphaproteobacteria,3JVRF@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S Tripartite tricarboxylate transporter TctA family - - - ko:K07793 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.80.1 - - TctA k59_1238598_1 1173024.KI912152_gene547 1.57e-08 60.1 COG1132@1|root,COG1132@2|Bacteria,1G1JY@1117|Cyanobacteria,1JJ9N@1189|Stigonemataceae 1117|Cyanobacteria V ABC transporter transmembrane region - - - ko:K06147 - - - - ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran k59_903545_2 640510.BC1001_1747 4.94e-55 196.0 2F5MT@1|root,33Y6V@2|Bacteria,1NWAY@1224|Proteobacteria,2W2TI@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_501301_1 1307759.JOMJ01000003_gene1396 3.3e-13 69.7 28I8B@1|root,2Z8B5@2|Bacteria,1MUNM@1224|Proteobacteria,42NZH@68525|delta/epsilon subdivisions,2WKHB@28221|Deltaproteobacteria,2M9ZJ@213115|Desulfovibrionales 28221|Deltaproteobacteria P Cytochrome c bacterial - - - - - - - - - - - - Cytochrome_C554,Cytochrome_C7,Cytochrome_cB k59_501301_2 1469613.JT55_04300 9.74e-60 190.0 COG4117@1|root,COG4117@2|Bacteria,1R5GN@1224|Proteobacteria,2U40G@28211|Alphaproteobacteria 28211|Alphaproteobacteria C Prokaryotic cytochrome b561 - - - - - - - - - - - - Ni_hydr_CYTB k59_1182912_1 1122137.AQXF01000001_gene3197 3.98e-51 180.0 COG0770@1|root,COG0770@2|Bacteria,1QTSF@1224|Proteobacteria,2TR0Q@28211|Alphaproteobacteria 28211|Alphaproteobacteria M Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein - - - - - - - - - - - - Mur_ligase_C,Mur_ligase_M k59_1349398_1 616991.JPOO01000001_gene3546 5.64e-128 367.0 COG0036@1|root,COG0036@2|Bacteria,4NDXB@976|Bacteroidetes,1HX41@117743|Flavobacteriia,23GWS@178469|Arenibacter 976|Bacteroidetes G Ribulose-phosphate 3 epimerase family rpe - 5.1.3.1 ko:K01783 ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007 R01529 RC00540 ko00000,ko00001,ko00002,ko01000 - - - Ribul_P_3_epim k59_1349398_2 1380384.JADN01000004_gene1793 6.04e-61 191.0 COG0517@1|root,COG0517@2|Bacteria,4NQYH@976|Bacteroidetes,1I24R@117743|Flavobacteriia 976|Bacteroidetes S CBS domain - - - - - - - - - - - - CBS k59_1414965_1 1382359.JIAL01000001_gene530 6.33e-68 215.0 COG3938@1|root,COG3938@2|Bacteria,3Y6TR@57723|Acidobacteria,2JKPS@204432|Acidobacteriia 204432|Acidobacteriia E Proline racemase - - 5.1.1.8 ko:K12658 ko00330,map00330 - R03296 RC00479 ko00000,ko00001,ko01000 - - - Pro_racemase k59_1641126_1 1266925.JHVX01000003_gene690 1.29e-149 435.0 COG1171@1|root,COG1171@2|Bacteria,1MVWJ@1224|Proteobacteria,2VI5U@28216|Betaproteobacteria,3722F@32003|Nitrosomonadales 28216|Betaproteobacteria E Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA ilvA GO:0006082,GO:0006520,GO:0006566,GO:0006807,GO:0008150,GO:0008152,GO:0009066,GO:0009987,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0071704,GO:1901564,GO:1901605 4.3.1.19 ko:K01754 ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230 M00570 R00220,R00996 RC00418,RC02600 ko00000,ko00001,ko00002,ko01000 - - - PALP,Thr_dehydrat_C k59_59485_1 1250005.PHEL85_0088 1.34e-120 372.0 COG0591@1|root,COG0642@1|root,COG0591@2|Bacteria,COG2205@2|Bacteria,4NE05@976|Bacteroidetes,1HY75@117743|Flavobacteriia 976|Bacteroidetes ET proline symporter - - - - - - - - - - - - HATPase_c,HisKA k59_341905_1 82654.Pse7367_3628 6.64e-116 342.0 COG3039@1|root,COG3039@2|Bacteria,1G1EK@1117|Cyanobacteria,1HEKZ@1150|Oscillatoriales 1117|Cyanobacteria L SPTR Transposase, IS4 family protein - - - - - - - - - - - - DDE_Tnp_1_3 k59_2661_1 1088721.NSU_3251 2.01e-132 405.0 COG1629@1|root,COG1629@2|Bacteria,COG4771@2|Bacteria,1MV8W@1224|Proteobacteria,2U0EP@28211|Alphaproteobacteria,2JZXV@204457|Sphingomonadales 204457|Sphingomonadales P receptor - - - - - - - - - - - - Plug,TonB_dep_Rec k59_1584430_1 316407.1799675 1.36e-93 279.0 COG1090@1|root,COG1090@2|Bacteria,1MUB4@1224|Proteobacteria,1RN6A@1236|Gammaproteobacteria,3XNPS@561|Escherichia 1236|Gammaproteobacteria S coenzyme binding yfcH - - ko:K07071 - - - - ko00000 - - - DUF1731,Epimerase k59_1584430_2 511145.b2303 3.1e-36 124.0 COG1539@1|root,COG1539@2|Bacteria,1RDHQ@1224|Proteobacteria,1S4Q3@1236|Gammaproteobacteria,3XPQY@561|Escherichia 1236|Gammaproteobacteria H Catalyzes the epimerization of carbon 2' of the side chain of 7,8-dihydroneopterin triphosphate (H2NTP) to form 7,8- dihydromonapterin triphosphate (H2MTP). Is required for tetrahydromonapterin biosynthesis folX GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0008719,GO:0009987,GO:0016853,GO:0019752,GO:0034641,GO:0042558,GO:0043436,GO:0043603,GO:0044237,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051186,GO:0071704,GO:1901360,GO:1901564 5.1.99.7 ko:K07589 ko00790,map00790 - R11082 RC01479 ko00000,ko00001,ko01000 - - - FolB k59_793865_1 1229909.NSED_03320 1.09e-42 146.0 COG1581@1|root,arCOG03441@1|root,arCOG01753@2157|Archaea,arCOG03441@2157|Archaea,41T5A@651137|Thaumarchaeota 651137|Thaumarchaeota K Alba - - - ko:K03622 - - - - ko00000 - - - Alba k59_793870_1 1283300.ATXB01000002_gene3137 2.92e-13 70.5 COG3385@1|root,COG3385@2|Bacteria 2|Bacteria L transposase activity - - - - - - - - - - - - DDE_Tnp_1,Dimer_Tnp_Tn5,Tnp_DNA_bind k59_1528117_1 669262.COK_1452 8.95e-64 206.0 COG0564@1|root,COG0564@2|Bacteria,1MVDX@1224|Proteobacteria,1RPAN@1236|Gammaproteobacteria,1Y6YV@135625|Pasteurellales 135625|Pasteurellales J Responsible for synthesis of pseudouridine from uracil rluC GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360 5.4.99.24 ko:K06179 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2,S4 k59_172494_1 883126.HMPREF9710_02132 0.000289 43.1 COG0556@1|root,COG0556@2|Bacteria,1MUFK@1224|Proteobacteria,2VHFQ@28216|Betaproteobacteria,472HG@75682|Oxalobacteraceae 28216|Betaproteobacteria L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage uvrB - - ko:K03702 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - Helicase_C,ResIII,UVR,UvrB k59_172494_2 1381123.AYOD01000015_gene2535 7.34e-87 263.0 COG0600@1|root,COG0600@2|Bacteria,1MWS0@1224|Proteobacteria,2VET7@28211|Alphaproteobacteria,43HMS@69277|Phyllobacteriaceae 28211|Alphaproteobacteria P ABC-type nitrate sulfonate bicarbonate transport system permease component MA20_40220 - - ko:K02050,ko:K15554 ko00920,ko02010,map00920,map02010 M00188,M00436 - - ko00000,ko00001,ko00002,ko02000 3.A.1.16,3.A.1.17,3.A.1.17.2 - - BPD_transp_1 k59_454677_1 1397528.Q671_14630 3.16e-12 68.6 COG1166@1|root,COG1166@2|Bacteria,1MU80@1224|Proteobacteria,1RP2J@1236|Gammaproteobacteria,1XHHF@135619|Oceanospirillales 135619|Oceanospirillales H Catalyzes the biosynthesis of agmatine from arginine speA - 4.1.1.19 ko:K01585 ko00330,ko01100,map00330,map01100 M00133 R00566 RC00299 ko00000,ko00001,ko00002,ko01000 - - - Orn_Arg_deC_N k59_454677_2 196162.Noca_3840 9.98e-05 44.7 COG1028@1|root,COG1028@2|Bacteria,2GNUM@201174|Actinobacteria,4DNX5@85009|Propionibacteriales 201174|Actinobacteria IQ Enoyl-(Acyl carrier protein) reductase - - - - - - - - - - - - adh_short,adh_short_C2 k59_906377_1 383381.EH30_10260 3.59e-108 318.0 COG1024@1|root,COG1024@2|Bacteria,1R3U7@1224|Proteobacteria,2TV9G@28211|Alphaproteobacteria,2K05Z@204457|Sphingomonadales 204457|Sphingomonadales I enoyl-CoA hydratase - - 4.2.1.17 ko:K01692 ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212 M00032,M00087 R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093 RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 - - - ECH_1 k59_680590_1 1448389.BAVQ01000029_gene653 5.83e-33 131.0 COG2124@1|root,COG2124@2|Bacteria,2GKCG@201174|Actinobacteria 201174|Actinobacteria Q cytochrome P450 - - 1.14.13.141 ko:K15981 ko00984,ko01120,map00984,map01120 - R09859,R11357 RC01216,RC03368 ko00000,ko00001,ko00199,ko01000 - - - p450 k59_511122_1 84531.JMTZ01000038_gene3655 1.71e-94 286.0 COG1622@1|root,COG1622@2|Bacteria,1MWHZ@1224|Proteobacteria,1RP4H@1236|Gammaproteobacteria,1X3HN@135614|Xanthomonadales 135614|Xanthomonadales C ubiquinol oxidase subunit cyoA - 1.10.3.10 ko:K02297 ko00190,ko01100,map00190,map01100 M00417 R11335 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.4.5 - - COX2,COX_ARM k59_850212_1 663278.Ethha_2716 5.08e-98 295.0 COG0216@1|root,COG0216@2|Bacteria,1TQ7V@1239|Firmicutes,248CN@186801|Clostridia,3WGA4@541000|Ruminococcaceae 186801|Clostridia J Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA prfA - - ko:K02835 - - - - ko00000,ko03012 - - - PCRF,RF-1 k59_454694_1 1121374.KB891586_gene2534 8.29e-101 303.0 COG0842@1|root,COG0842@2|Bacteria,1MW5R@1224|Proteobacteria,1RPB4@1236|Gammaproteobacteria 1236|Gammaproteobacteria V ABC-type multidrug transport system, permease component ybhS - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_3 k59_963101_1 1268237.G114_06857 1.52e-34 135.0 2DBW6@1|root,2ZBEP@2|Bacteria,1QUH5@1224|Proteobacteria,1RY0G@1236|Gammaproteobacteria 1236|Gammaproteobacteria C TIGRFAM decaheme c-type cytochrome, OmcA MtrC family - - - - - - - - - - - - Cytochrome_C7 k59_59524_2 388051.AUFE01000048_gene2420 7.02e-13 69.7 COG3181@1|root,COG3181@2|Bacteria,1R68W@1224|Proteobacteria,2VM2X@28216|Betaproteobacteria 28216|Betaproteobacteria S protein conserved in bacteria - - - - - - - - - - - - TctC k59_285441_2 1192759.AKIB01000069_gene3853 1.64e-36 135.0 COG3670@1|root,COG3670@2|Bacteria,1NQQK@1224|Proteobacteria,2UPR0@28211|Alphaproteobacteria,2K90Y@204457|Sphingomonadales 204457|Sphingomonadales Q Retinal pigment epithelial membrane protein - - - ko:K11159 - - - - ko00000 - - - RPE65 k59_850225_1 46234.ANA_C11804 4.82e-88 294.0 COG1020@1|root,COG1020@2|Bacteria,1G0XE@1117|Cyanobacteria,1HKNU@1161|Nostocales 1117|Cyanobacteria Q TIGRFAM amino acid adenylation domain - - - - - - - - - - - - AMP-binding,AMP-binding_C,Condensation,Methyltransf_25,PP-binding,Thioesterase k59_963110_1 1288494.EBAPG3_21460 8.5e-82 267.0 COG1034@1|root,COG1034@2|Bacteria,1P8MN@1224|Proteobacteria,2VJYV@28216|Betaproteobacteria,372H6@32003|Nitrosomonadales 28216|Betaproteobacteria C Molybdopterin oxidoreductase Fe4S4 domain nuoG - 1.6.5.3 ko:K00336 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Fer2_4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3 k59_1245793_1 502025.Hoch_5121 1.99e-09 66.2 COG2304@1|root,COG2304@2|Bacteria,1REJW@1224|Proteobacteria,43BIH@68525|delta/epsilon subdivisions,2X6WV@28221|Deltaproteobacteria,2YVF8@29|Myxococcales 28221|Deltaproteobacteria S Von Willebrand factor type A - - - ko:K07114 - - - - ko00000,ko02000 1.A.13.2.2,1.A.13.2.3 - - VWA k59_1528155_1 1045856.EcWSU1_01458 2.49e-45 152.0 COG0580@1|root,COG0580@2|Bacteria,1MXTJ@1224|Proteobacteria,1RPKU@1236|Gammaproteobacteria,3X02S@547|Enterobacter 1236|Gammaproteobacteria G Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity aqpZ GO:0003674,GO:0005215,GO:0005372,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006833,GO:0006884,GO:0006950,GO:0006970,GO:0008150,GO:0008361,GO:0009628,GO:0009987,GO:0009992,GO:0015250,GO:0015267,GO:0015318,GO:0016020,GO:0016021,GO:0016043,GO:0019725,GO:0022803,GO:0022838,GO:0022857,GO:0030104,GO:0031224,GO:0031226,GO:0032535,GO:0042044,GO:0042592,GO:0042802,GO:0044425,GO:0044459,GO:0044464,GO:0048878,GO:0050896,GO:0051179,GO:0051234,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0071840,GO:0071944,GO:0090066 - ko:K06188 - - - - ko00000,ko02000 1.A.8 - - MIP k59_59541_1 1232410.KI421422_gene2085 2.75e-105 313.0 COG2358@1|root,COG2358@2|Bacteria,1MXW1@1224|Proteobacteria,42MGJ@68525|delta/epsilon subdivisions,2WJ5E@28221|Deltaproteobacteria 28221|Deltaproteobacteria S TIGRFAM TRAP transporter solute receptor, TAXI family - - - ko:K07080 - - - - ko00000 - - - NMT1_3 k59_1471699_1 436308.Nmar_1367 1.78e-43 155.0 arCOG08650@1|root,arCOG08650@2157|Archaea,41SZ5@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1302336_2 1121448.DGI_0294 3.25e-29 117.0 COG1164@1|root,COG1164@2|Bacteria,1MXAC@1224|Proteobacteria,42NAD@68525|delta/epsilon subdivisions,2WKEY@28221|Deltaproteobacteria,2MFEP@213115|Desulfovibrionales 28221|Deltaproteobacteria E Oligopeptidase F pepF - - ko:K08602 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M3,Peptidase_M3_N k59_1697607_1 555793.WSK_2462 2.83e-221 613.0 COG2141@1|root,COG2141@2|Bacteria,1MXZH@1224|Proteobacteria,2TQJH@28211|Alphaproteobacteria,2K3GK@204457|Sphingomonadales 204457|Sphingomonadales C Catalyzes the pyrimidine ring opening between N-3 and C- 4 by an unusual flavin hydroperoxide-catalyzed mechanism to yield ureidoacrylate peracid. It cleaves pyrmidine rings directly by adding oxygen atoms, making a toxic ureidoacrylate peracid product which can be spontaneously reduced to ureidoacrylate rutA - 1.14.99.46 ko:K09018 ko00240,ko01100,map00240,map01100 - R09936 RC02732 ko00000,ko00001,ko01000 - - - Bac_luciferase k59_1697607_2 1144305.PMI02_03909 6.44e-67 211.0 COG2267@1|root,COG2267@2|Bacteria,1MVAI@1224|Proteobacteria,2U64E@28211|Alphaproteobacteria,2K41E@204457|Sphingomonadales 204457|Sphingomonadales I May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation rutD - - - - - - - - - - - Abhydrolase_1 k59_1020004_1 471223.GWCH70_0254 1.14e-52 180.0 COG0026@1|root,COG0026@2|Bacteria,1TQCD@1239|Firmicutes,4H9M5@91061|Bacilli,1WEUV@129337|Geobacillus 91061|Bacilli F Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) purK GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 6.3.4.18 ko:K01589 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R07404 RC01927 ko00000,ko00001,ko00002,ko01000 - - - 2-Hacid_dh_C,ATP-grasp k59_341980_1 864051.BurJ1DRAFT_1799 3.11e-56 187.0 COG0604@1|root,COG0604@2|Bacteria,1QUNT@1224|Proteobacteria,2VM3W@28216|Betaproteobacteria 28216|Betaproteobacteria C Protein of unknown function (DUF2855) - - - - - - - - - - - - DUF2855 k59_906420_1 946077.W5A_04738 1.32e-88 276.0 COG0457@1|root,COG0457@2|Bacteria,4NH87@976|Bacteroidetes,1HZMD@117743|Flavobacteriia 976|Bacteroidetes S Tetratricopeptide repeat - - - - - - - - - - - - TPR_8 k59_567903_1 1121116.KB894765_gene1033 5.76e-18 81.6 COG3917@1|root,COG3917@2|Bacteria,1RJFB@1224|Proteobacteria,2VPYN@28216|Betaproteobacteria,4ACDE@80864|Comamonadaceae 28216|Betaproteobacteria Q 2-hydroxychromene-2-carboxylate isomerase - - - - - - - - - - - - DSBA k59_567903_2 795666.MW7_0207 9.13e-11 64.7 COG0491@1|root,COG0491@2|Bacteria,1NCIF@1224|Proteobacteria,2VJVR@28216|Betaproteobacteria,1K41C@119060|Burkholderiaceae 28216|Betaproteobacteria S beta-lactamase - - - - - - - - - - - - Lactamase_B k59_737586_1 946483.Cenrod_1746 1.9e-46 179.0 COG0642@1|root,COG0745@1|root,COG2198@1|root,COG2199@1|root,COG0745@2|Bacteria,COG2198@2|Bacteria,COG2205@2|Bacteria,COG3706@2|Bacteria,1NRP8@1224|Proteobacteria,2VGZQ@28216|Betaproteobacteria 28216|Betaproteobacteria T Histidine kinase bvgS2 - - ko:K14978 ko02020,map02020 M00663 - - ko00000,ko00001,ko00002,ko01001,ko02022 - - - HATPase_c,HisKA,Hpt,PAS,PAS_3,PAS_4,PAS_7,Response_reg k59_285487_1 573413.Spirs_1449 2.48e-32 130.0 COG3707@1|root,COG5001@1|root,COG3707@2|Bacteria,COG5001@2|Bacteria,2JBHK@203691|Spirochaetes 203691|Spirochaetes T Diguanylate cyclase (GGDEF) domain - - - - - - - - - - - - EAL,GGDEF,PAS,Response_reg,dCache_1 k59_1020010_1 247634.GPB2148_751 1.47e-14 75.9 COG0174@1|root,COG0174@2|Bacteria,1MU6V@1224|Proteobacteria,1RPNZ@1236|Gammaproteobacteria,1J8HS@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Glutamine synthetase, catalytic domain - - 6.3.1.2 ko:K01915 ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 - R00253 RC00010,RC02798 ko00000,ko00001,ko01000,ko04147 - - - Gln-synt_C k59_285490_1 713586.KB900536_gene961 8.1e-88 275.0 COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,1RMQQ@1236|Gammaproteobacteria,1WWDG@135613|Chromatiales 135613|Chromatiales E TIGRFAM Acetolactate synthase, large subunit, biosynthetic - - - - - - - - - - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_964356_1 1136138.JH604622_gene2494 9.76e-31 114.0 COG3193@1|root,COG3193@2|Bacteria,1N08N@1224|Proteobacteria,1S8SV@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Glcg protein glcG - - - - - - - - - - - Haem_degrading k59_1529308_1 1030157.AFMP01000007_gene3150 5.2e-62 202.0 COG0462@1|root,COG0462@2|Bacteria,1MUV7@1224|Proteobacteria,2U3AB@28211|Alphaproteobacteria,2K1GU@204457|Sphingomonadales 204457|Sphingomonadales F Belongs to the ribose-phosphate pyrophosphokinase family - - 2.7.6.1 ko:K00948 ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230 M00005 R01049 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - Pribosyltran,Pribosyltran_N k59_1529308_2 161156.JQKW01000012_gene35 1.34e-34 132.0 COG2199@1|root,COG3706@2|Bacteria,2GHY7@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria T diguanylate cyclase - - - - - - - - - - - - GGDEF k59_399438_1 316407.85677039 2.36e-35 127.0 COG0329@1|root,COG0329@2|Bacteria,1MXI1@1224|Proteobacteria,1RPXI@1236|Gammaproteobacteria,3XQAY@561|Escherichia 1236|Gammaproteobacteria EM Catalyze the formation of 2-keto-3-deoxy-gluconate (KDG) from pyruvate and glyceraldehyde. May also function as a 2-dehydro-3-deoxy-D-pentonate aldolase. Overexpression leads to increased growth (over 2 hours) in the presence of the antibiotics norfloxacin, ampicillin and streptomycin yjhH GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005975,GO:0006082,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016052,GO:0016054,GO:0016829,GO:0016830,GO:0016832,GO:0019520,GO:0019752,GO:0032787,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044262,GO:0044275,GO:0044281,GO:0044282,GO:0046176,GO:0046395,GO:0047440,GO:0071704,GO:0072329,GO:1901575 4.1.2.28,4.3.3.7 ko:K01714,ko:K22397 ko00040,ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00040,map00261,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R01782,R10147 RC00307,RC00572,RC03062,RC03063 ko00000,ko00001,ko00002,ko01000 - - - DHDPS k59_399438_2 316407.85677040 2.14e-94 280.0 COG1414@1|root,COG1414@2|Bacteria,1R3KG@1224|Proteobacteria,1S144@1236|Gammaproteobacteria,3XRJX@561|Escherichia 1236|Gammaproteobacteria K negative regulation of nucleic acid-templated transcription yjhI GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0005488,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0045892,GO:0045934,GO:0046483,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 - - - - - - - - - - HTH_IclR,IclR k59_343176_1 1545915.JROG01000001_gene547 5.18e-89 278.0 COG3507@1|root,COG3507@2|Bacteria,1MWY2@1224|Proteobacteria,2U0K4@28211|Alphaproteobacteria,2K29U@204457|Sphingomonadales 204457|Sphingomonadales G Belongs to the glycosyl hydrolase 43 family - - - - - - - - - - - - Glyco_hydro_43 k59_1698705_1 743974.MBO_09523 3.15e-21 97.4 COG1502@1|root,COG1502@2|Bacteria,1MUDJ@1224|Proteobacteria,1RMIF@1236|Gammaproteobacteria,3NK7J@468|Moraxellaceae 1236|Gammaproteobacteria I Phospholipase D clsC GO:0003674,GO:0003824,GO:0005575,GO:0006629,GO:0006644,GO:0006650,GO:0006655,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0008808,GO:0009058,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016780,GO:0019637,GO:0030572,GO:0032048,GO:0032049,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0045017,GO:0046471,GO:0046474,GO:0046486,GO:0071704,GO:0090407,GO:0090483,GO:1901576 - ko:K06132 ko00564,ko01100,map00564,map01100 - R11062 RC00017 ko00000,ko00001,ko01000 - - - PLDc_2 k59_1416129_1 158500.BV97_01042 1.51e-07 52.4 2AQW1@1|root,31G4F@2|Bacteria,1NNTM@1224|Proteobacteria,2UNE2@28211|Alphaproteobacteria,2K7U0@204457|Sphingomonadales 204457|Sphingomonadales - - - - - - - - - - - - - - - k59_795009_1 1122137.AQXF01000001_gene3118 4.16e-270 754.0 COG1138@1|root,COG1138@2|Bacteria,1MUQS@1224|Proteobacteria,2TRNG@28211|Alphaproteobacteria 28211|Alphaproteobacteria O Cytochrome c-type biogenesis protein ccmF - - ko:K02198 - - - - ko00000,ko02000 9.B.14.1 - - CcmF_C,Cytochrom_C_asm k59_795009_2 690585.JNNU01000005_gene3330 1.64e-16 76.6 COG2332@1|root,COG2332@2|Bacteria,1RHN5@1224|Proteobacteria,2U99J@28211|Alphaproteobacteria,4BE68@82115|Rhizobiaceae 28211|Alphaproteobacteria O Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH ccmE GO:0003674,GO:0003824,GO:0008150,GO:0009987,GO:0016043,GO:0017004,GO:0022607,GO:0034622,GO:0043933,GO:0044085,GO:0065003,GO:0071840 - ko:K02197 - - - - ko00000 - - - CcmE k59_343195_1 1236959.BAMT01000008_gene2475 2.21e-85 272.0 COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,2VH3Q@28216|Betaproteobacteria,2KKSN@206350|Nitrosomonadales 206350|Nitrosomonadales F Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen - - 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - Ribonuc_red_lgC,Ribonuc_red_lgN k59_229813_1 227377.CBU_1828 4.02e-34 131.0 COG1565@1|root,COG1565@2|Bacteria,1N3CJ@1224|Proteobacteria,1RYCJ@1236|Gammaproteobacteria,1JCPM@118969|Legionellales 118969|Legionellales S Putative S-adenosyl-L-methionine-dependent methyltransferase - - - - - - - - - - - - Methyltransf_28 k59_455896_1 572477.Alvin_0412 1.12e-84 261.0 COG0624@1|root,COG0624@2|Bacteria,1MW6G@1224|Proteobacteria,1RMNQ@1236|Gammaproteobacteria,1WWQK@135613|Chromatiales 135613|Chromatiales E Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls dapE - 3.5.1.18 ko:K01439 ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230 M00016 R02734 RC00064,RC00090 ko00000,ko00001,ko00002,ko01000 - - - M20_dimer,Peptidase_M20 k59_1303447_1 1463854.JOHT01000010_gene44 2.75e-08 57.0 COG1028@1|root,COG1028@2|Bacteria,2GN6U@201174|Actinobacteria 201174|Actinobacteria IQ Belongs to the short-chain dehydrogenases reductases (SDR) family - - 1.1.1.100 ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 k59_1303447_2 1380356.JNIK01000001_gene2126 8.11e-29 111.0 COG0346@1|root,COG0346@2|Bacteria 2|Bacteria E lactoylglutathione lyase activity - - 5.1.99.1 ko:K05606 ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200 M00373,M00375,M00376,M00741 R02765,R09979 RC00780,RC02739 ko00000,ko00001,ko00002,ko01000 - - - Glyoxalase,Glyoxalase_3,Glyoxalase_4 k59_1077099_1 1415778.JQMM01000001_gene345 1.91e-53 181.0 COG1167@1|root,COG1167@2|Bacteria,1MUUI@1224|Proteobacteria,1RQDS@1236|Gammaproteobacteria,1J4U4@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria EK COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs aspC - - - - - - - - - - - Aminotran_MocR k59_60761_1 1122137.AQXF01000001_gene3004 2.4e-119 361.0 COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,1MWGR@1224|Proteobacteria,2TRTE@28211|Alphaproteobacteria 28211|Alphaproteobacteria EU COG1506 Dipeptidyl aminopeptidases acylaminoacyl-peptidases - - - - - - - - - - - - PD40,Peptidase_S9 k59_60761_2 1227499.C493_05960 1.2e-06 54.3 COG1574@1|root,arCOG00691@2157|Archaea,2XUUZ@28890|Euryarchaeota,23SFX@183963|Halobacteria 183963|Halobacteria S metal-dependent hydrolase with the TIM-barrel fold - - - - - - - - - - - - Amidohydro_3 k59_173684_1 1120953.AUBH01000001_gene1320 8.68e-133 398.0 COG2838@1|root,COG2838@2|Bacteria,1MV6Q@1224|Proteobacteria,1RPG4@1236|Gammaproteobacteria,464R6@72275|Alteromonadaceae 1236|Gammaproteobacteria C Isocitrate dehydrogenase icd - 1.1.1.42 ko:K00031 ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146 M00009,M00010,M00173,M00740 R00267,R00268,R01899 RC00001,RC00084,RC00114,RC00626,RC02801 br01601,ko00000,ko00001,ko00002,ko01000 - - - IDH k59_229825_1 1049564.TevJSym_ao00280 1.5e-57 201.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria 1224|Proteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_286692_1 935866.JAER01000001_gene2609 4.82e-17 85.5 COG2203@1|root,COG4585@1|root,COG2203@2|Bacteria,COG4585@2|Bacteria,2GIXR@201174|Actinobacteria,4DV7H@85009|Propionibacteriales 201174|Actinobacteria T Histidine kinase-like ATPases - - - - - - - - - - - - HisKA_3 k59_343210_2 1169161.KB897720_gene4011 8e-91 277.0 COG0078@1|root,COG0078@2|Bacteria,2GJ6H@201174|Actinobacteria 201174|Actinobacteria E Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline argF GO:0000050,GO:0003674,GO:0003824,GO:0004585,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0016743,GO:0019627,GO:0019752,GO:0034641,GO:0042450,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.1.3.3 ko:K00611 ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230 M00029,M00844 R01398 RC00096 ko00000,ko00001,ko00002,ko01000 - - - OTCace,OTCace_N k59_1698753_1 1122137.AQXF01000003_gene2186 2.33e-93 282.0 COG1419@1|root,COG1419@2|Bacteria,1MUQW@1224|Proteobacteria,2U06N@28211|Alphaproteobacteria 28211|Alphaproteobacteria N COG1419 Flagellar GTP-binding protein flhF - - ko:K02404 - - - - ko00000,ko02035 - - - SRP54 k59_1077111_2 713586.KB900536_gene1418 7.48e-12 65.9 COG1508@1|root,COG1508@2|Bacteria,1MW4V@1224|Proteobacteria,1RMY0@1236|Gammaproteobacteria,1WVZD@135613|Chromatiales 135613|Chromatiales K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released - - - ko:K03092 ko02020,ko05111,map02020,map05111 - - - ko00000,ko00001,ko03021 - - - Sigma54_AID,Sigma54_CBD,Sigma54_DBD k59_399471_1 443598.AUFA01000011_gene514 1.46e-73 230.0 COG1028@1|root,COG1028@2|Bacteria,1P9R4@1224|Proteobacteria,2TTJ5@28211|Alphaproteobacteria,3JUTG@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria IQ Enoyl-(Acyl carrier protein) reductase - - 1.3.1.33 ko:K00218 ko00860,ko01100,ko01110,map00860,map01100,map01110 - R03845,R06286 RC01008 ko00000,ko00001,ko01000 - - - adh_short k59_117268_2 398767.Glov_1901 2.92e-29 116.0 COG0519@1|root,COG0519@2|Bacteria,1MU2A@1224|Proteobacteria,42M0I@68525|delta/epsilon subdivisions,2WJ6D@28221|Deltaproteobacteria 28221|Deltaproteobacteria F Catalyzes the synthesis of GMP from XMP guaA GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046037,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 6.3.5.2 ko:K01951 ko00230,ko00983,ko01100,map00230,map00983,map01100 M00050 R01230,R01231,R08244 RC00010,RC00204 ko00000,ko00001,ko00002,ko01000,ko01002 - - - GATase,GMP_synt_C,NAD_synthase,tRNA_Me_trans k59_229839_1 690850.Desaf_2747 3.5e-26 110.0 COG0784@1|root,COG2206@1|root,COG0784@2|Bacteria,COG2206@2|Bacteria,1RAQS@1224|Proteobacteria,42QQI@68525|delta/epsilon subdivisions,2X706@28221|Deltaproteobacteria,2MHI4@213115|Desulfovibrionales 28221|Deltaproteobacteria T sensor protein - - - - - - - - - - - - GAF_2,HD,HD_5,PAS,PAS_4,PAS_9,Response_reg,sCache_2 k59_512303_1 1229909.NSED_09040 1.9e-211 594.0 COG0004@1|root,arCOG04397@2157|Archaea,41SY0@651137|Thaumarchaeota 651137|Thaumarchaeota P Ammonium Transporter - - - ko:K03320 - - - - ko00000,ko02000 1.A.11 - - Ammonium_transp k59_1077124_2 1121022.ABENE_01805 3.85e-11 59.3 2C7TH@1|root,32RJS@2|Bacteria,1MZK8@1224|Proteobacteria,2UC2R@28211|Alphaproteobacteria,2KGYS@204458|Caulobacterales 204458|Caulobacterales S ETC complex I subunit - - - - - - - - - - - - ETC_C1_NDUFA4 k59_964404_1 1528106.JRJE01000009_gene1622 3.72e-15 70.1 COG5481@1|root,COG5481@2|Bacteria,1NG9U@1224|Proteobacteria,2UFXJ@28211|Alphaproteobacteria,2JUNA@204441|Rhodospirillales 204441|Rhodospirillales S Protein of unknown function (DUF465) - - - - - - - - - - - - DUF465 k59_117276_1 477184.KYC_12208 1.12e-16 76.3 COG1802@1|root,COG1802@2|Bacteria,1RDCR@1224|Proteobacteria,2W242@28216|Betaproteobacteria,3T7XP@506|Alcaligenaceae 28216|Betaproteobacteria K FCD - - - - - - - - - - - - FCD,GntR k59_117276_2 477184.KYC_12138 1.51e-95 286.0 COG3777@1|root,COG3777@2|Bacteria,1P96N@1224|Proteobacteria,2VIUS@28216|Betaproteobacteria,3T6SJ@506|Alcaligenaceae 28216|Betaproteobacteria S N-terminal half of MaoC dehydratase - - 4.2.1.153 ko:K09709 ko00720,ko01120,ko01200,map00720,map01120,map01200 M00376 R09282 RC02479 ko00000,ko00001,ko00002,ko01000 - - - MaoC_dehydrat_N k59_1021215_1 1122137.AQXF01000005_gene1252 9.2e-223 624.0 COG0402@1|root,COG0402@2|Bacteria,1MVPA@1224|Proteobacteria,2TSZ0@28211|Alphaproteobacteria 28211|Alphaproteobacteria F COG0402 Cytosine deaminase and related metal-dependent hydrolases - - 3.5.4.28,3.5.4.31 ko:K12960 ko00270,ko01100,map00270,map01100 - R09660 RC00477 ko00000,ko00001,ko01000 - - - Amidohydro_1 k59_795051_1 998088.B565_2580 2.27e-73 236.0 COG2225@1|root,COG2225@2|Bacteria,1MVEV@1224|Proteobacteria,1RPVI@1236|Gammaproteobacteria,1Y6CP@135624|Aeromonadales 135624|Aeromonadales C Malate synthase aceB - 2.3.3.9 ko:K01638 ko00620,ko00630,ko01100,ko01110,ko01120,ko01200,map00620,map00630,map01100,map01110,map01120,map01200 M00012 R00472 RC00004,RC00308,RC02747 ko00000,ko00001,ko00002,ko01000 - - - Malate_synthase k59_907781_2 349521.HCH_03797 3.91e-24 100.0 COG0583@1|root,COG0583@2|Bacteria,1MWM1@1224|Proteobacteria,1RZDI@1236|Gammaproteobacteria,1XP09@135619|Oceanospirillales 135619|Oceanospirillales K LysR substrate binding domain - - - - - - - - - - - - HTH_1,LysR_substrate k59_1303481_2 436308.Nmar_1777 5.87e-50 164.0 COG0846@1|root,arCOG04248@2157|Archaea,41SWP@651137|Thaumarchaeota 651137|Thaumarchaeota K NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form. Deacetylates the N-terminal lysine residue of Alba, the major archaeal chromatin protein and that, in turn, increases Alba's DNA binding affinity, thereby repressing transcription cobB - - ko:K12410 - - - - ko00000,ko01000 - - - SIR2 k59_1472829_1 1122137.AQXF01000003_gene1921 9.28e-40 137.0 COG0712@1|root,COG0712@2|Bacteria,1MVRH@1224|Proteobacteria,2U5IC@28211|Alphaproteobacteria 28211|Alphaproteobacteria C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation atpH - - ko:K02113 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - OSCP k59_1472829_2 991905.SL003B_4217 4.51e-59 196.0 COG0056@1|root,COG0056@2|Bacteria,1MUG7@1224|Proteobacteria,2TQYK@28211|Alphaproteobacteria,4BP9Z@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria C Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit atpA - 3.6.3.14 ko:K02111 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - - ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N k59_1256260_1 84531.JMTZ01000006_gene3514 3.12e-60 209.0 COG0460@1|root,COG0527@1|root,COG0460@2|Bacteria,COG0527@2|Bacteria,1MW3H@1224|Proteobacteria,1RN1G@1236|Gammaproteobacteria,1X4R3@135614|Xanthomonadales 135614|Xanthomonadales E homoserine dehydrogenase thrA - 1.1.1.3,2.7.2.4 ko:K12524 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00017,M00018,M00526,M00527 R00480,R01773,R01775 RC00002,RC00043,RC00087 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase,ACT,ACT_7,Homoserine_dh,NAD_binding_3 k59_521351_1 1454004.AW11_01634 1.47e-38 146.0 COG2217@1|root,COG2608@1|root,COG2217@2|Bacteria,COG2608@2|Bacteria,1MU08@1224|Proteobacteria,2VJSM@28216|Betaproteobacteria,1KQDM@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria P Heavy-metal-associated domain ccoI - 3.6.3.4 ko:K01533 - - R00086 RC00002 ko00000,ko01000 3.A.3.5 - - ATPase-cat_bd,E1-E2_ATPase,HMA,Hydrolase k59_521351_2 1123487.KB892841_gene4276 8.02e-16 71.6 COG3197@1|root,COG3197@2|Bacteria,1NG90@1224|Proteobacteria,2VWG5@28216|Betaproteobacteria,2KXI0@206389|Rhodocyclales 206389|Rhodocyclales P Cytochrome oxidase maturation protein cbb3-type - - - - - - - - - - - - FixS k59_521351_3 1232683.ADIMK_2592 4.86e-27 110.0 COG0589@1|root,COG3945@1|root,COG0589@2|Bacteria,COG3945@2|Bacteria,1MZ3K@1224|Proteobacteria,1SFMR@1236|Gammaproteobacteria 1236|Gammaproteobacteria T universal stress protein - - - - - - - - - - - - Usp k59_1369921_1 1137269.AZWL01000014_gene779 9.83e-15 75.5 COG0153@1|root,COG0153@2|Bacteria 2|Bacteria G galactokinase activity galK - 2.7.1.6 ko:K00849 ko00052,ko00520,ko01100,map00052,map00520,map01100 M00554,M00632 R01092 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000,ko04147 - - - GHMP_kinases_C,GHMP_kinases_N,GalKase_gal_bdg k59_1369921_2 926550.CLDAP_28980 3.33e-60 196.0 COG1085@1|root,COG1085@2|Bacteria,2G6K5@200795|Chloroflexi 200795|Chloroflexi H TIGRFAM galactose-1-phosphate uridylyltransferase galT - 2.7.7.12 ko:K00965 ko00052,ko00520,ko01100,ko04917,map00052,map00520,map01100,map04917 M00362,M00554,M00632 R00955 RC00002 ko00000,ko00001,ko00002,ko01000 - - - GalP_UDP_tr_C,GalP_UDP_transf k59_634834_1 1117647.M5M_00067 2.49e-139 407.0 COG0008@1|root,COG0008@2|Bacteria,1MUCR@1224|Proteobacteria,1RN3R@1236|Gammaproteobacteria,1J547@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) gltX GO:0003674,GO:0003824,GO:0004812,GO:0004818,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006424,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.17 ko:K01885 ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120 M00121,M00359,M00360 R05578 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016 - - iEC042_1314.EC042_2616 tRNA-synt_1c k59_1595226_1 645512.GCWU000246_01691 1.76e-15 80.9 COG0568@1|root,COG0568@2|Bacteria,3TACS@508458|Synergistetes 508458|Synergistetes K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth sigA - - ko:K03086 - - - - ko00000,ko03021 - - - Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4 k59_1313397_1 1121930.AQXG01000001_gene1238 0.000924 45.4 COG3832@1|root,COG3832@2|Bacteria,4NR9F@976|Bacteroidetes 976|Bacteroidetes S Activator of Hsp90 ATPase - - - - - - - - - - - - AHSA1 k59_126886_1 1134474.O59_000654 4.39e-90 284.0 COG1200@1|root,COG1200@2|Bacteria,1MWN2@1224|Proteobacteria,1RMMQ@1236|Gammaproteobacteria,1FGW4@10|Cellvibrio 1236|Gammaproteobacteria L Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) recG GO:0003674,GO:0003678,GO:0003724,GO:0003824,GO:0004003,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006807,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0008186,GO:0009314,GO:0009379,GO:0009628,GO:0009987,GO:0010501,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0032991,GO:0033202,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0051276,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:0140098,GO:1901360,GO:1902494 3.6.4.12 ko:K03655 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,Helicase_C,RecG_wedge k59_521355_1 319236.JCM19294_1959 1.66e-35 126.0 COG1136@1|root,COG1136@2|Bacteria,4NE5N@976|Bacteroidetes,1HXPP@117743|Flavobacteriia,3HJWU@363408|Nonlabens 976|Bacteroidetes V membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides macB - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_521355_2 1123037.AUDE01000002_gene23 2.26e-43 145.0 COG2096@1|root,COG2096@2|Bacteria,4NFHQ@976|Bacteroidetes,1HX1J@117743|Flavobacteriia 976|Bacteroidetes S adenosyltransferase yvqK - 2.5.1.17 ko:K00798 ko00860,ko01100,map00860,map01100 M00122 R01492,R05220,R07268 RC00533 ko00000,ko00001,ko00002,ko01000 - - - Cob_adeno_trans k59_1425539_1 1267535.KB906767_gene5335 3e-44 158.0 COG3328@1|root,COG3328@2|Bacteria 2|Bacteria L transposase activity - - - ko:K07497 - - - - ko00000 - - - Transposase_mut k59_634853_2 1033730.CAHG01000008_gene3007 5.33e-09 59.3 COG0526@1|root,COG0526@2|Bacteria,2IMNX@201174|Actinobacteria,4DRHV@85009|Propionibacteriales 201174|Actinobacteria CO Redoxin resA_1 - - - - - - - - - - - AhpC-TSA,Redoxin k59_1540376_4 35754.JNYJ01000003_gene6476 1.44e-55 186.0 COG2141@1|root,COG2141@2|Bacteria,2GJI7@201174|Actinobacteria,4DADW@85008|Micromonosporales 201174|Actinobacteria C Luciferase-like monooxygenase - - - - - - - - - - - - Bac_luciferase k59_184371_1 316407.85676949 1.87e-123 353.0 COG0235@1|root,COG0235@2|Bacteria,1MU54@1224|Proteobacteria,1RMIP@1236|Gammaproteobacteria,3XM68@561|Escherichia 1236|Gammaproteobacteria G Catalyzes the isomerization of L-ribulose 5-phosphate to D-xylulose 5-phosphate. Is involved in the anaerobic L-ascorbate utilization ulaF GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008270,GO:0008742,GO:0009056,GO:0009058,GO:0009987,GO:0016052,GO:0016829,GO:0016830,GO:0016832,GO:0016853,GO:0016854,GO:0016857,GO:0019321,GO:0019323,GO:0019324,GO:0019566,GO:0019568,GO:0019569,GO:0019572,GO:0019637,GO:0019752,GO:0019852,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046373,GO:0046872,GO:0046914,GO:0051167,GO:0051186,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901159,GO:1901575,GO:1901576 5.1.3.4 ko:K03077 ko00040,ko00053,ko01100,ko01120,map00040,map00053,map01100,map01120 M00550 R05850 RC01479 ko00000,ko00001,ko00002,ko01000 - - iECO111_1330.ECO111_4403,iSDY_1059.SDY_4367,iSSON_1240.SSON_0067 Aldolase_II k59_1144287_1 350688.Clos_2362 6.34e-30 122.0 COG3829@1|root,COG3829@2|Bacteria,1TP0E@1239|Firmicutes,247MB@186801|Clostridia,36DY7@31979|Clostridiaceae 186801|Clostridia KT PFAM sigma-54 factor interaction domain-containing protein - - - ko:K06714 - - - - ko00000,ko03000 - - - HTH_8,PAS,PAS_9,Sigma54_activat k59_692485_2 745310.G432_21575 3.84e-48 160.0 COG2865@1|root,COG2865@2|Bacteria,1RDDZ@1224|Proteobacteria,2U7CD@28211|Alphaproteobacteria,2KA2G@204457|Sphingomonadales 204457|Sphingomonadales - - - - - - - - - - - - - - - k59_184375_1 644107.SL1157_1308 2.87e-32 126.0 COG1228@1|root,COG1228@2|Bacteria,1MVAF@1224|Proteobacteria,2TTYC@28211|Alphaproteobacteria,4NCZP@97050|Ruegeria 28211|Alphaproteobacteria Q Amidohydrolase family - - - - - - - - - - - - Amidohydro_1 k59_1144291_1 199310.c0145 2.71e-149 431.0 COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,1RMFF@1236|Gammaproteobacteria,3XM8F@561|Escherichia 1236|Gammaproteobacteria F Lipoamide dehydrogenase is a component of the glycine cleavage system as well as of the alpha-ketoacid dehydrogenase complexes lpdA GO:0000166,GO:0001505,GO:0003674,GO:0003824,GO:0004148,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006084,GO:0006085,GO:0006086,GO:0006090,GO:0006103,GO:0006139,GO:0006163,GO:0006164,GO:0006520,GO:0006544,GO:0006546,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008270,GO:0009056,GO:0009058,GO:0009063,GO:0009069,GO:0009071,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015036,GO:0016054,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0017144,GO:0018130,GO:0019438,GO:0019464,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0032991,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0035383,GO:0035384,GO:0036094,GO:0042133,GO:0042135,GO:0042737,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0043603,GO:0043604,GO:0043648,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0045250,GO:0045254,GO:0046390,GO:0046395,GO:0046483,GO:0046872,GO:0046914,GO:0048037,GO:0050660,GO:0050662,GO:0050896,GO:0051186,GO:0051188,GO:0055086,GO:0055114,GO:0065007,GO:0065008,GO:0071616,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1902494,GO:1990204 1.8.1.4 ko:K00382 ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00036,M00307,M00532 R00209,R01221,R01698,R03815,R07618,R08549 RC00004,RC00022,RC00583,RC02742,RC02833,RC02834 br01601,ko00000,ko00001,ko00002,ko01000,ko04147 - - iAPECO1_1312.APECO1_1869,iEcolC_1368.EcolC_3543,iPC815.YPO3417,iSFV_1184.SFV_0107,iUMN146_1321.UM146_23385 Biotin_lipoyl,Pyr_redox_2,Pyr_redox_dim k59_806020_1 1144305.PMI02_03618 1.54e-21 94.4 COG1706@1|root,COG1706@2|Bacteria,1MVKW@1224|Proteobacteria,2TQNX@28211|Alphaproteobacteria,2K00I@204457|Sphingomonadales 204457|Sphingomonadales N Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation flgI - - ko:K02394 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - FlgI k59_806020_2 1096930.L284_05365 5.69e-83 255.0 COG1377@1|root,COG1377@2|Bacteria,1MUWI@1224|Proteobacteria,2TS13@28211|Alphaproteobacteria,2K0RR@204457|Sphingomonadales 204457|Sphingomonadales N Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin flhB - - ko:K02401 ko02040,map02040 - - - ko00000,ko00001,ko02035,ko02044 3.A.6.2 - - Bac_export_2 k59_1201164_2 478749.BRYFOR_06086 7.54e-18 85.1 2FFDF@1|root,347B2@2|Bacteria,1VYJJ@1239|Firmicutes,256XH@186801|Clostridia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - - k59_579470_1 1123392.AQWL01000005_gene2896 1.58e-61 199.0 COG1656@1|root,COG1656@2|Bacteria,1R442@1224|Proteobacteria,2VN8Q@28216|Betaproteobacteria,1KS9T@119069|Hydrogenophilales 119069|Hydrogenophilales S Mut7-C ubiquitin - - - ko:K09122 - - - - ko00000 - - - Mut7-C,Ub-Mut7C k59_1709348_1 164757.Mjls_5534 8.82e-47 155.0 COG5517@1|root,COG5517@2|Bacteria,2HS6X@201174|Actinobacteria,23AUM@1762|Mycobacteriaceae 201174|Actinobacteria Q Domain of unknown function (DUF4440) - - - - - - - - - - - - SnoaL_4 k59_240380_1 208444.JNYY01000002_gene1229 1.57e-06 55.1 COG2114@1|root,COG2114@2|Bacteria,2GJRI@201174|Actinobacteria,4DZBF@85010|Pseudonocardiales 201174|Actinobacteria T Adenylate and Guanylate cyclase catalytic domain - - 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 - - - Guanylate_cyc,HAMP k59_240383_1 1448860.BBJO01000065_gene3272 8.83e-21 96.7 COG1165@1|root,arCOG04611@2157|Archaea,2XUM8@28890|Euryarchaeota,23TJ0@183963|Halobacteria 183963|Halobacteria H Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) menD - 2.2.1.9 ko:K02551 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116 R08165 RC02186 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M_2,TPP_enzyme_N k59_635982_1 1454004.AW11_00170 2.98e-57 197.0 COG0751@1|root,COG0751@2|Bacteria,1MV2F@1224|Proteobacteria,2VICG@28216|Betaproteobacteria,1KPSF@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria J Glycyl-tRNA synthetase beta subunit glyS - 6.1.1.14 ko:K01879 ko00970,map00970 M00360 R03654 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DALR_1,tRNA_synt_2f k59_1087934_1 379731.PST_0001 1.12e-98 303.0 COG0593@1|root,COG0593@2|Bacteria,1MU5H@1224|Proteobacteria,1RNHP@1236|Gammaproteobacteria,1Z1T4@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria L it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids dnaA GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003688,GO:0003690,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006275,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010556,GO:0016020,GO:0017076,GO:0019219,GO:0019222,GO:0030554,GO:0031323,GO:0031326,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0035639,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0051052,GO:0051171,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0090304,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901363,GO:1901576,GO:1990837,GO:2000112 - ko:K02313 ko02020,ko04112,map02020,map04112 - - - ko00000,ko00001,ko03032,ko03036 - - - Bac_DnaA,Bac_DnaA_C,DnaA_N k59_1257372_1 4787.PITG_15694T0 0.000307 42.4 COG0418@1|root,KOG2902@2759|Eukaryota,3Q930@4776|Peronosporales 4776|Peronosporales F Amidohydrolase family - - - - - - - - - - - - Amidohydro_1 k59_1257372_2 489825.LYNGBM3L_15550 3.91e-25 101.0 COG0583@1|root,COG0583@2|Bacteria,1G0RE@1117|Cyanobacteria,1H8FB@1150|Oscillatoriales 1117|Cyanobacteria K Bacterial regulatory helix-turn-helix protein, lysR family rbcR - - ko:K21703 - - - - ko00000,ko03000 - - - HTH_1,LysR_substrate k59_918557_1 1205908.AKXW01000045_gene3643 1.31e-44 160.0 COG1680@1|root,COG1680@2|Bacteria,1P3SQ@1224|Proteobacteria,1SWQV@1236|Gammaproteobacteria,1XSBM@135623|Vibrionales 135623|Vibrionales V Beta-lactamase - - - - - - - - - - - - Beta-lactamase k59_354316_1 941449.dsx2_3134 3.6e-66 209.0 COG2080@1|root,COG2080@2|Bacteria,1N1KQ@1224|Proteobacteria,42UD3@68525|delta/epsilon subdivisions,2WPH9@28221|Deltaproteobacteria,2M9N0@213115|Desulfovibrionales 28221|Deltaproteobacteria C 2Fe-2S -binding - - - - - - - - - - - - Fer2,Fer2_2 k59_579506_1 143224.JQMD01000002_gene269 0.000518 47.4 COG1073@1|root,COG1073@2|Bacteria 2|Bacteria S thiolester hydrolase activity - - - ko:K06889 - - - - ko00000 - - - AXE1,Hydrolase_4 k59_522545_1 1123401.JHYQ01000007_gene544 3.41e-38 136.0 COG3381@1|root,COG3381@2|Bacteria,1MWWM@1224|Proteobacteria,1S449@1236|Gammaproteobacteria,462Q6@72273|Thiotrichales 72273|Thiotrichales S Nitrate reductase delta subunit - - - - - - - - - - - - Nitrate_red_del k59_15027_1 1396141.BATP01000039_gene1279 3.57e-27 111.0 COG0673@1|root,COG0673@2|Bacteria,46Z3T@74201|Verrucomicrobia,2IU84@203494|Verrucomicrobiae 2|Bacteria S Oxidoreductase family, NAD-binding Rossmann fold - - 1.1.99.28 ko:K00118 - - - - ko00000,ko01000 - - - GFO_IDH_MocA,GFO_IDH_MocA_C k59_128108_1 228399.appser1_2710 4.79e-18 84.3 COG0083@1|root,COG0083@2|Bacteria,1MW8I@1224|Proteobacteria,1RMYR@1236|Gammaproteobacteria,1Y6T2@135625|Pasteurellales 135625|Pasteurellales E Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate thrB GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004413,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006555,GO:0006566,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009086,GO:0009088,GO:0009092,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019202,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.1.39 ko:K00872 ko00260,ko01100,ko01110,ko01120,ko01230,map00260,map01100,map01110,map01120,map01230 M00018 R01771 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - GHMP_kinases_C,GHMP_kinases_N k59_128108_2 1392490.JHZX01000001_gene781 2.37e-32 115.0 2AR54@1|root,31GER@2|Bacteria,4NSCR@976|Bacteroidetes,1I3DE@117743|Flavobacteriia 976|Bacteroidetes J 30S ribosomal protein S23 - - - - - - - - - - - - 23S_rRNA_IVP k59_863156_1 1144275.COCOR_05212 1.15e-10 65.1 COG3210@1|root,COG3210@2|Bacteria,1P4K4@1224|Proteobacteria 1224|Proteobacteria U domain, Protein - - - - - - - - - - - - - k59_1709392_1 419610.Mext_3686 1.43e-26 110.0 COG3547@1|root,COG3547@2|Bacteria,1MXKJ@1224|Proteobacteria,2U2G6@28211|Alphaproteobacteria,1JUTG@119045|Methylobacteriaceae 28211|Alphaproteobacteria L transposase IS116 IS110 IS902 family protein - - - ko:K07486 - - - - ko00000 - - - DEDD_Tnp_IS110,Transposase_20 k59_184434_1 379066.GAU_3235 5.6e-22 100.0 COG2091@1|root,COG2091@2|Bacteria,1ZUGF@142182|Gemmatimonadetes 142182|Gemmatimonadetes H lysine biosynthetic process via aminoadipic acid - - - - - - - - - - - - - k59_240419_1 436308.Nmar_1245 1.18e-71 238.0 COG0419@1|root,COG1122@1|root,arCOG00202@2157|Archaea,arCOG00368@2157|Archaea,41S9P@651137|Thaumarchaeota 651137|Thaumarchaeota LP AAA domain - - - ko:K03546 - - - - ko00000,ko03400 - - - AAA_15 k59_974244_1 1415778.JQMM01000001_gene93 3.08e-64 209.0 COG0560@1|root,COG0560@2|Bacteria,1MWA3@1224|Proteobacteria,1RNJE@1236|Gammaproteobacteria,1J58R@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E phosphoserine phosphatase serB GO:0000287,GO:0001505,GO:0003674,GO:0003824,GO:0004647,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006544,GO:0006545,GO:0006563,GO:0006564,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0017144,GO:0019752,GO:0042133,GO:0042136,GO:0042578,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046872,GO:0065007,GO:0065008,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 3.1.3.3 ko:K01079 ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230 M00020 R00582 RC00017 ko00000,ko00001,ko00002,ko01000,ko01009 - - iE2348C_1286.E2348C_4686,iEC042_1314.EC042_4885,iECO26_1355.ECO26_5594,iECSF_1327.ECSF_4321,iECUMN_1333.ECUMN_5012,iETEC_1333.ETEC_4743,iPC815.YPO0442,iUMNK88_1353.UMNK88_5307 ACT_6,HAD,Hydrolase k59_806051_1 323848.Nmul_A0313 4.02e-90 282.0 COG0449@1|root,COG0449@2|Bacteria,1MW4K@1224|Proteobacteria,2VHVY@28216|Betaproteobacteria,3721Z@32003|Nitrosomonadales 28216|Betaproteobacteria M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source glmS - 2.6.1.16 ko:K00820 ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931 - R00768 RC00010,RC00163,RC02752 ko00000,ko00001,ko01000,ko01002 - - - GATase_6,SIS k59_1144333_1 1122137.AQXF01000002_gene245 3.23e-103 307.0 COG0809@1|root,COG0809@2|Bacteria,1MUH3@1224|Proteobacteria,2TS0D@28211|Alphaproteobacteria 28211|Alphaproteobacteria J Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) queA GO:0002097,GO:0002099,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016853,GO:0018130,GO:0019438,GO:0034404,GO:0034470,GO:0034641,GO:0034654,GO:0034660,GO:0042455,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0051075,GO:0055086,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.4.99.17 ko:K07568 - - - - ko00000,ko01000,ko03016 - - - Queuosine_synth k59_1144333_2 1174684.EBMC1_03310 4.14e-16 76.6 COG0343@1|root,COG0343@2|Bacteria,1MUCA@1224|Proteobacteria,2TR87@28211|Alphaproteobacteria,2K0II@204457|Sphingomonadales 204457|Sphingomonadales J Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) tgt - 2.4.2.29 ko:K00773 - - R03789,R10209 RC00063 ko00000,ko01000,ko03016 - - - TGT k59_863174_1 76114.ebA4237 1.51e-93 281.0 COG0109@1|root,COG0109@2|Bacteria,1MW3S@1224|Proteobacteria,2VHZU@28216|Betaproteobacteria,2KVHR@206389|Rhodocyclales 206389|Rhodocyclales H Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group ctaB - 2.5.1.141 ko:K02257 ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714 M00154 R07411 RC01786 ko00000,ko00001,ko00002,ko01000,ko01006,ko03029 - - - UbiA k59_1709417_1 1492738.FEM21_26700 2.91e-07 51.6 COG0591@1|root,COG0591@2|Bacteria,4NEN8@976|Bacteroidetes,1HYVB@117743|Flavobacteriia,2NYPU@237|Flavobacterium 976|Bacteroidetes E Sodium:solute symporter family - - - ko:K03307 - - - - ko00000 2.A.21 - - SSF k59_1709417_2 714943.Mucpa_6779 7e-37 142.0 COG3395@1|root,COG3395@2|Bacteria,4NJ9I@976|Bacteroidetes,1IRZK@117747|Sphingobacteriia 976|Bacteroidetes S Putative sugar-binding N-terminal domain - - 2.7.1.219,2.7.1.220 ko:K22129 - - - - ko00000,ko01000 - - - DUF1357_C,DUF1537 k59_1540450_1 504728.K649_09785 6.41e-23 99.0 COG0179@1|root,COG0179@2|Bacteria,1WJ13@1297|Deinococcus-Thermus 2|Bacteria Q COGs COG0179 2-keto-4-pentenoate hydratase 2-oxohepta-3-ene-1 7-dioic acid hydratase (catechol pathway) - - - - - - - - - - - - FAA_hydrolase k59_748824_1 998674.ATTE01000001_gene673 7.86e-84 252.0 COG0740@1|root,COG0740@2|Bacteria,1MV46@1224|Proteobacteria,1RNR6@1236|Gammaproteobacteria,45ZYA@72273|Thiotrichales 72273|Thiotrichales OU Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins clpP - 3.4.21.92 ko:K01358 ko04112,ko04212,map04112,map04212 - - - ko00000,ko00001,ko01000,ko01002 - - - CLP_protease k59_1201236_2 1122137.AQXF01000001_gene3194 7.13e-125 365.0 COG0491@1|root,COG0491@2|Bacteria,1PKW8@1224|Proteobacteria,2TUW8@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Metallo-beta-lactamase superfamily - - - - - - - - - - - - Lactamase_B k59_1201236_3 1122137.AQXF01000001_gene3195 6.34e-35 129.0 COG1181@1|root,COG1181@2|Bacteria,1MUTB@1224|Proteobacteria,2TREC@28211|Alphaproteobacteria 28211|Alphaproteobacteria F Belongs to the D-alanine--D-alanine ligase family ddlA - 6.3.2.4 ko:K01921 ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502 - R01150 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Dala_Dala_lig_C,Dala_Dala_lig_N k59_184473_1 1169143.KB911039_gene4603 1.83e-30 120.0 COG1082@1|root,COG1082@2|Bacteria,1R3UQ@1224|Proteobacteria,2VKWW@28216|Betaproteobacteria,1K547@119060|Burkholderiaceae 28216|Betaproteobacteria G Xylose isomerase-like TIM barrel - - - - - - - - - - - - AP_endonuc_2 k59_354366_1 1224163.B841_04950 6.31e-14 70.5 COG2518@1|root,COG2518@2|Bacteria,2HH7X@201174|Actinobacteria,22NB5@1653|Corynebacteriaceae 201174|Actinobacteria O Protein-L-isoaspartate carboxylmethyltransferase - - 2.1.1.77 ko:K00573 - - - - ko00000,ko01000 - - - PCMT k59_354366_2 868131.MSWAN_1119 1.15e-19 88.6 arCOG11926@1|root,arCOG11926@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_128142_1 335283.Neut_1724 3.1e-70 233.0 COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,2VH8J@28216|Betaproteobacteria,371XZ@32003|Nitrosomonadales 28216|Betaproteobacteria P TIGRFAM ATPase, P-type (transporting), HAD superfamily, subfamily IC actP - 3.6.3.54 ko:K17686 ko01524,ko04016,map01524,map04016 - R00086 RC00002 ko00000,ko00001,ko01000 3.A.3.5 - - E1-E2_ATPase,Hydrolase,YHS k59_1766015_1 318161.Sden_2610 2.32e-44 163.0 COG1629@1|root,COG1629@2|Bacteria,1MV8W@1224|Proteobacteria,1RQEQ@1236|Gammaproteobacteria,2QEKH@267890|Shewanellaceae 1236|Gammaproteobacteria P TonB-dependent receptor plug - - - - - - - - - - - - Plug,TonB_dep_Rec k59_918604_1 373994.Riv7116_0639 6.37e-25 106.0 COG0136@1|root,COG0136@2|Bacteria,1G0E6@1117|Cyanobacteria,1HJMM@1161|Nostocales 1117|Cyanobacteria E Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate asd - 1.2.1.11 ko:K00133 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00017,M00018,M00033,M00525,M00526,M00527 R02291 RC00684 ko00000,ko00001,ko00002,ko01000 - - - Semialdhyde_dh,Semialdhyde_dhC k59_1653468_1 926560.KE387023_gene2143 9.41e-75 231.0 COG1051@1|root,COG1051@2|Bacteria,1WK9S@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus F NUDIX domain - - 3.6.1.55 ko:K03574 - - - - ko00000,ko01000,ko03400 - - - NUDIX k59_1144354_1 1336245.JAGO01000003_gene588 1.18e-135 417.0 COG0458@1|root,COG0458@2|Bacteria,1MUDZ@1224|Proteobacteria,1RPIU@1236|Gammaproteobacteria,1XHKH@135619|Oceanospirillales 135619|Oceanospirillales F Carbamoyl-phosphate synthetase ammonia chain carB - 6.3.5.5 ko:K01955 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - - CPSase_L_D2,CPSase_L_D3,MGS k59_1314607_1 1122611.KB903985_gene3886 1.61e-28 114.0 COG1804@1|root,COG1804@2|Bacteria,2GKNX@201174|Actinobacteria,4EHVM@85012|Streptosporangiales 201174|Actinobacteria C CoA-transferase family III - - 5.1.99.4 ko:K01796 ko00120,ko01100,ko04146,map00120,map01100,map04146 M00104 R08734,R08739 RC02345 ko00000,ko00001,ko00002,ko01000 - - - CoA_transf_3 k59_748853_1 1380390.JIAT01000010_gene4616 1.89e-41 153.0 COG1020@1|root,COG1020@2|Bacteria,2GKGU@201174|Actinobacteria,4CQYP@84995|Rubrobacteria 84995|Rubrobacteria Q Protein of unknown function (DUF1298) - - - - - - - - - - - - DUF1298,WES_acyltransf k59_863198_1 1123073.KB899242_gene1460 5.17e-100 309.0 COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,1NBSJ@1224|Proteobacteria,1S0WV@1236|Gammaproteobacteria,1X99Q@135614|Xanthomonadales 135614|Xanthomonadales C Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg - - - - - - - - - - - - POR,POR_N k59_926616_1 1144342.PMI40_01166 3.36e-18 85.9 COG4630@1|root,COG4630@2|Bacteria,1MWI1@1224|Proteobacteria,2VI0J@28216|Betaproteobacteria 28216|Betaproteobacteria C Xanthine dehydrogenase small subunit xdhA - 1.17.1.4 ko:K13481 ko00230,ko01100,ko01120,map00230,map01100,map01120 M00546 R01768,R02103 RC00143 ko00000,ko00001,ko00002,ko01000 - - - CO_deh_flav_C,FAD_binding_5,Fer2,Fer2_2 k59_926616_2 667632.KB890171_gene3584 7.29e-19 86.3 COG4631@1|root,COG4631@2|Bacteria,1NQSR@1224|Proteobacteria,2VHYR@28216|Betaproteobacteria,1K0FS@119060|Burkholderiaceae 28216|Betaproteobacteria C aldehyde oxidase and xanthine dehydrogenase, a b hammerhead xdhB - 1.17.1.4 ko:K13482 ko00230,ko01100,ko01120,map00230,map01100,map01120 M00546 R01768,R02103 RC00143 ko00000,ko00001,ko00002,ko01000 - - - Ald_Xan_dh_C,Ald_Xan_dh_C2 k59_701810_1 158500.BV97_03869 2.72e-129 375.0 COG0117@1|root,COG1985@1|root,COG0117@2|Bacteria,COG1985@2|Bacteria,1MUWT@1224|Proteobacteria,2TR70@28211|Alphaproteobacteria,2K10R@204457|Sphingomonadales 204457|Sphingomonadales H Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate ribD - 1.1.1.193,3.5.4.26 ko:K11752 ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024 M00125 R03458,R03459 RC00204,RC00933 ko00000,ko00001,ko00002,ko01000 - - - RibD_C,dCMP_cyt_deam_1 k59_1493572_1 1121877.JQKF01000009_gene575 5.14e-50 166.0 COG1143@1|root,COG1143@2|Bacteria,2GJNU@201174|Actinobacteria,4CMPP@84992|Acidimicrobiia 84992|Acidimicrobiia C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient - - 1.6.5.3 ko:K00338 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Fer4 k59_1493572_2 110319.CF8_0455 3.77e-13 69.3 COG1005@1|root,COG1005@2|Bacteria,2GIVY@201174|Actinobacteria,4DNAD@85009|Propionibacteriales 201174|Actinobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone nuoH - 1.6.5.3 ko:K00337 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - iNJ661.Rv3152 NADHdh k59_813712_1 740709.A10D4_03645 2.21e-77 241.0 COG3267@1|root,COG3267@2|Bacteria,1MU3G@1224|Proteobacteria,1RMI0@1236|Gammaproteobacteria,2QFTV@267893|Idiomarinaceae 1236|Gammaproteobacteria U Uncharacterized conserved protein (DUF2075) mshM - - ko:K12283 - - - - ko00000,ko02044 - - - AAA_22 k59_813712_2 225849.swp_0488 7.15e-05 44.7 COG1450@1|root,COG1450@2|Bacteria,1MVNC@1224|Proteobacteria,1RQGJ@1236|Gammaproteobacteria,2Q9FP@267890|Shewanellaceae 1236|Gammaproteobacteria NU Type II and III secretion system protein mshL - - ko:K12282 - - - - ko00000,ko02044 - - - STN,Secretin,Secretin_N_2 k59_1380322_1 316407.85676161 7.72e-151 429.0 COG1363@1|root,COG1363@2|Bacteria,1MXEU@1224|Proteobacteria,1RYRZ@1236|Gammaproteobacteria,3XN5P@561|Escherichia 1236|Gammaproteobacteria G Has a broad aminopeptidase activity on non-blocked peptides by progressively cleaving amino acids off the peptide substrate. Aminopeptidase activity stops at the residue before the first proline in the peptide. Cannot cleave when proline is the first N-terminal residue frvX GO:0003674,GO:0003824,GO:0004177,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0008238,GO:0016787,GO:0019538,GO:0043170,GO:0044238,GO:0070011,GO:0071704,GO:0140096,GO:1901564 - ko:K18530,ko:K20609 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M42 k59_363806_1 479433.Caci_5774 6.28e-23 96.7 COG1028@1|root,COG1028@2|Bacteria,2GKT2@201174|Actinobacteria 201174|Actinobacteria IQ Short-chain dehydrogenase reductase sdr - - - - - - - - - - - - adh_short,adh_short_C2 k59_1606046_1 436308.Nmar_1731 3.55e-75 234.0 COG0075@1|root,arCOG00082@2157|Archaea,41SZZ@651137|Thaumarchaeota 651137|Thaumarchaeota E Aminotransferase class-V - - - - - - - - - - - - Aminotran_5 k59_363813_1 1056820.KB900652_gene3248 1.65e-14 70.1 COG1416@1|root,COG1416@2|Bacteria,1NAV2@1224|Proteobacteria,1SXJ3@1236|Gammaproteobacteria,2PPIR@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_363813_2 435908.IDSA_09860 1.83e-28 114.0 COG2377@1|root,COG2377@2|Bacteria,1MV4E@1224|Proteobacteria,1RNTZ@1236|Gammaproteobacteria,2QF07@267893|Idiomarinaceae 1236|Gammaproteobacteria F Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling anmK - 2.7.1.170 ko:K09001 - - - - ko00000,ko01000 - - - AnmK k59_872294_1 1229909.NSED_07580 4.25e-131 392.0 COG3593@1|root,arCOG03235@2157|Archaea,41SZV@651137|Thaumarchaeota 651137|Thaumarchaeota L AAA ATPase domain - - - - - - - - - - - - AAA_15 k59_872294_2 1229909.NSED_07575 6.83e-05 44.7 arCOG10583@1|root,arCOG10583@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_1606051_1 998674.ATTE01000001_gene3666 6.57e-41 148.0 COG2192@1|root,COG2192@2|Bacteria,1MWBA@1224|Proteobacteria,1RNN4@1236|Gammaproteobacteria,45ZSA@72273|Thiotrichales 72273|Thiotrichales O PFAM Carbamoyltransferase - - - ko:K00612 - - - - ko00000,ko01000 - - - Carbam_trans_C,Carbam_trans_N k59_1606051_2 498211.CJA_2488 1.22e-18 83.2 2DP8V@1|root,33122@2|Bacteria,1NC2I@1224|Proteobacteria,1SCSG@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_1606051_3 744985.HIMB59_00003540 2.97e-14 66.2 2EGPU@1|root,33AFZ@2|Bacteria,1NH69@1224|Proteobacteria,2UJXH@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_644082_1 1033743.CAES01000103_gene3523 8.82e-23 100.0 COG1680@1|root,COG1680@2|Bacteria,1UZZ5@1239|Firmicutes,4HA1I@91061|Bacilli,26XEG@186822|Paenibacillaceae 91061|Bacilli V Beta-lactamase - - 3.4.16.4 ko:K01286 - - - - ko00000,ko01000 - - - Beta-lactamase k59_1718821_1 1229909.NSED_05640 3.14e-19 84.3 COG5012@1|root,arCOG03402@2157|Archaea 2157|Archaea T Cobalamin B12-binding domain protein - - - ko:K16955,ko:K22491 ko00920,map00920 - R09997 RC00035 ko00000,ko00001,ko03000 - - - B12-binding,B12-binding_2 k59_1718821_3 436308.Nmar_0977 5.24e-17 80.9 COG0702@1|root,arCOG03015@2157|Archaea 2157|Archaea GM NAD-dependent epimerase dehydratase - - 4.2.1.46 ko:K01710 ko00521,ko00523,ko00525,ko01055,ko01130,map00521,map00523,map00525,map01055,map01130 M00793 R06513 RC00402 ko00000,ko00001,ko00002,ko01000 - - - NAD_binding_10 k59_1210282_1 1229909.NSED_02375 1.09e-152 451.0 COG1948@1|root,arCOG02284@2157|Archaea,41T0R@651137|Thaumarchaeota 651137|Thaumarchaeota L Beta propeller domain - - - - - - - - - - - - Beta_propel k59_1434812_1 649747.HMPREF0083_00261 1.56e-51 182.0 COG5001@1|root,COG5001@2|Bacteria,1TP8V@1239|Firmicutes,4HA3G@91061|Bacilli,26QWH@186822|Paenibacillaceae 91061|Bacilli T Diguanylate cyclase - - - - - - - - - - - - EAL,GGDEF,PAS,PAS_4,PAS_9 k59_192688_1 452637.Oter_1154 9.76e-25 109.0 COG3391@1|root,COG4625@1|root,COG5563@1|root,COG3391@2|Bacteria,COG4625@2|Bacteria,COG5563@2|Bacteria 2|Bacteria T pathogenesis - - 3.1.3.1,3.1.3.5,3.1.3.8,3.6.1.45 ko:K01077,ko:K01083,ko:K07004,ko:K11751 ko00230,ko00240,ko00562,ko00730,ko00760,ko00790,ko01100,ko01110,ko02020,map00230,map00240,map00562,map00730,map00760,map00790,map01100,map01110,map02020 M00126 R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02135,R02323,R02719,R03346,R03371,R04620 RC00017,RC00078 ko00000,ko00001,ko00002,ko00537,ko01000,ko04147 - - - 5_nucleotid_C,Calx-beta,Phytase-like k59_1322367_1 448385.sce5075 2.31e-06 53.1 COG2339@1|root,COG3266@1|root,COG2339@2|Bacteria,COG3266@2|Bacteria,1P8NV@1224|Proteobacteria 1224|Proteobacteria S Protease prsW family - - - - - - - - - - - - PrsW-protease k59_1380363_1 388051.AUFE01000001_gene1907 4.58e-89 273.0 COG0282@1|root,COG0282@2|Bacteria,1MW61@1224|Proteobacteria,2VHRC@28216|Betaproteobacteria,1K1WI@119060|Burkholderiaceae 28216|Betaproteobacteria H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction ackA - 2.7.2.1 ko:K00925 ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200 M00357,M00579 R00315,R01353 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - Acetate_kinase k59_1434822_1 1088721.NSU_1824 7.21e-117 367.0 COG0145@1|root,COG0146@1|root,COG0145@2|Bacteria,COG0146@2|Bacteria,1MU2Y@1224|Proteobacteria,2TQZ6@28211|Alphaproteobacteria,2K2G6@204457|Sphingomonadales 204457|Sphingomonadales EQ COG0145 N-methylhydantoinase A acetone carboxylase, beta subunit - - 3.5.2.9 ko:K01469 ko00480,map00480 - R00251 RC00553 ko00000,ko00001,ko01000 - - - Hydant_A_N,Hydantoinase_A,Hydantoinase_B k59_588657_1 887327.HMPREF0476_1867 4.14e-25 109.0 COG1034@1|root,COG1034@2|Bacteria,1P8MN@1224|Proteobacteria,2VJYV@28216|Betaproteobacteria,2KPGN@206351|Neisseriales 206351|Neisseriales C NADH-quinone oxidoreductase nuoG - 1.6.5.3 ko:K00336 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Fer2_4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3 k59_872320_1 869210.Marky_0538 1.91e-22 98.6 COG1397@1|root,COG1397@2|Bacteria,1WNF2@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus O ADP-ribosylglycohydrolase - - - - - - - - - - - - ADP_ribosyl_GH k59_1210300_1 187272.Mlg_2637 2.17e-46 164.0 COG1519@1|root,COG1519@2|Bacteria,1MU9F@1224|Proteobacteria,1RNBR@1236|Gammaproteobacteria,1WX73@135613|Chromatiales 135613|Chromatiales M PFAM Three-deoxy-D-manno-octulosonic-acid transferase - - 2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15 ko:K02527 ko00540,ko01100,map00540,map01100 M00060,M00080 R04658,R05074,R09763 RC00009,RC00077,RC00247 ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT30 - Glycos_transf_1,Glycos_transf_N,Kdo k59_1606085_1 666681.M301_1678 2.17e-05 50.8 COG2887@1|root,COG2887@2|Bacteria,1QU90@1224|Proteobacteria,2VHNR@28216|Betaproteobacteria,2KMEP@206350|Nitrosomonadales 206350|Nitrosomonadales L PD-(D/E)XK nuclease superfamily - - 3.1.11.5 ko:K01144 - - - - ko00000,ko01000 - - - PDDEXK_1 k59_1606085_2 1122194.AUHU01000005_gene1120 5.24e-37 139.0 COG1074@1|root,COG1074@2|Bacteria,1MUTF@1224|Proteobacteria,1RPC6@1236|Gammaproteobacteria,46518@72275|Alteromonadaceae 1236|Gammaproteobacteria L UvrD-like helicase C-terminal domain addA - - - - - - - - - - - PDDEXK_1,UvrD-helicase,UvrD_C k59_419077_1 1278073.MYSTI_03189 3.95e-11 66.6 COG1714@1|root,COG1714@2|Bacteria,1NB1Z@1224|Proteobacteria 1224|Proteobacteria S membrane protein domain - - - - - - - - - - - - DUF4339,RDD k59_419077_2 685035.ADAE01000002_gene2212 3.14e-24 102.0 COG1785@1|root,COG1785@2|Bacteria,1MXI2@1224|Proteobacteria,2TTUZ@28211|Alphaproteobacteria,2K1RI@204457|Sphingomonadales 204457|Sphingomonadales P Belongs to the alkaline phosphatase family - - 3.1.3.1 ko:K01077 ko00730,ko00790,ko01100,ko02020,map00730,map00790,map01100,map02020 M00126 R02135,R04620 RC00017 ko00000,ko00001,ko00002,ko00537,ko01000,ko04147 - - - Alk_phosphatase k59_192706_1 566466.NOR53_1048 1.23e-61 213.0 COG0653@1|root,COG0653@2|Bacteria,1MUJZ@1224|Proteobacteria,1RM9M@1236|Gammaproteobacteria,1J56C@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane secA GO:0000166,GO:0002790,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006457,GO:0006605,GO:0006810,GO:0006886,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0009306,GO:0009987,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032940,GO:0032991,GO:0033036,GO:0033220,GO:0034613,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042802,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0046903,GO:0046907,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0061077,GO:0065002,GO:0070727,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680 - ko:K03070 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4 - - SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW k59_1718853_1 43228.XP_007738810.1 7.44e-15 69.3 2D6AE@1|root,2T1BT@2759|Eukaryota,3ARVI@33154|Opisthokonta,3PFWT@4751|Fungi,3R4XB@4890|Ascomycota,20NVX@147545|Eurotiomycetes 4751|Fungi - - - - - - - - - - - - - - - k59_1153328_1 987059.RBXJA2T_15018 1.6e-16 78.6 COG0626@1|root,COG0626@2|Bacteria,1MU57@1224|Proteobacteria,2VHAC@28216|Betaproteobacteria 28216|Betaproteobacteria E COG0626 Cystathionine beta-lyases cystathionine gamma-synthases metC - 2.5.1.48,4.4.1.1,4.4.1.11,4.4.1.8 ko:K01739,ko:K01758,ko:K01760,ko:K01761 ko00260,ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00260,map00270,map00450,map00920,map01100,map01110,map01130,map01230 M00017,M00338 R00654,R00782,R00999,R01001,R01286,R01288,R02408,R02508,R03217,R03260,R04770,R04930,R04941,R04944,R04945,R04946,R09366 RC00020,RC00056,RC00069,RC00196,RC00348,RC00382,RC00420,RC00488,RC00710,RC01209,RC01210,RC01245,RC02303,RC02848,RC02866 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Cys_Met_Meta_PP k59_701888_1 1248760.ANFZ01000009_gene777 7.05e-11 61.6 COG1629@1|root,COG1629@2|Bacteria,COG4771@2|Bacteria,1MV8W@1224|Proteobacteria,2U1TG@28211|Alphaproteobacteria,2KD9C@204457|Sphingomonadales 204457|Sphingomonadales P TonB dependent receptor - - - - - - - - - - - - Plug,TonB_dep_Rec k59_701888_2 555500.I215_02218 8.36e-06 51.6 COG0657@1|root,COG1621@1|root,COG0657@2|Bacteria,COG1621@2|Bacteria,4NH62@976|Bacteroidetes,1HYAU@117743|Flavobacteriia 976|Bacteroidetes I PFAM alpha beta hydrolase fold - - - - - - - - - - - - Abhydrolase_3,Peptidase_S9 k59_1210314_1 953739.SVEN_4345 6.49e-195 577.0 COG0085@1|root,COG0085@2|Bacteria,2GJ81@201174|Actinobacteria 201174|Actinobacteria K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoB GO:0000428,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0030880,GO:0032991,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0061695,GO:0071944,GO:1902494,GO:1990234 2.7.7.6 ko:K03043 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7 k59_1493651_1 498211.CJA_2520 2.83e-34 135.0 COG1022@1|root,COG5184@1|root,COG5276@1|root,COG1022@2|Bacteria,COG5184@2|Bacteria,COG5276@2|Bacteria,1PG4J@1224|Proteobacteria,1RWXR@1236|Gammaproteobacteria,1FIEH@10|Cellvibrio 1236|Gammaproteobacteria DZ Regulator of chromosome condensation (RCC1) repeat - - - - - - - - - - - - RCC1 k59_474468_1 1380356.JNIK01000015_gene2463 8.53e-76 234.0 COG1028@1|root,COG1028@2|Bacteria,2HP88@201174|Actinobacteria,4EVZD@85013|Frankiales 201174|Actinobacteria IQ KR domain - - 1.1.1.100 ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 k59_1493656_1 1333523.L593_04175 5.38e-14 77.0 COG0517@1|root,arCOG00607@2157|Archaea,2XTE5@28890|Euryarchaeota,23SWA@183963|Halobacteria 183963|Halobacteria S Belongs to the peptidase M50B family - - - - - - - - - - - - CBS,Peptidase_M50 k59_1606118_1 1123368.AUIS01000018_gene726 7.53e-112 332.0 COG0499@1|root,COG0499@2|Bacteria,1MUQ2@1224|Proteobacteria,1RMW8@1236|Gammaproteobacteria,2NBU1@225057|Acidithiobacillales 225057|Acidithiobacillales H May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine ahcY - 3.3.1.1 ko:K01251 ko00270,ko01100,map00270,map01100 M00035 R00192,R04936 RC00056,RC00069,RC01161,RC01243 ko00000,ko00001,ko00002,ko01000,ko01009,ko04147 - - - AdoHcyase,AdoHcyase_NAD k59_1434849_1 1229909.NSED_02080 4.73e-55 177.0 COG0071@1|root,arCOG01833@2157|Archaea,41SPJ@651137|Thaumarchaeota 651137|Thaumarchaeota O Belongs to the small heat shock protein (HSP20) family - - - ko:K13993 ko04141,map04141 - - - ko00000,ko00001,ko03110 - - - HSP20 k59_1661906_1 1046714.AMRX01000007_gene2265 1.97e-39 143.0 COG4658@1|root,COG4658@2|Bacteria,1MVY6@1224|Proteobacteria,1RMEU@1236|Gammaproteobacteria,464JB@72275|Alteromonadaceae 1236|Gammaproteobacteria C Part of a membrane complex involved in electron transport rnfD GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016651,GO:0044464,GO:0055114,GO:0071944 - ko:K03614 - - - - ko00000 - - - NQR2_RnfD_RnfE k59_1493662_1 366602.Caul_3779 1.47e-64 213.0 COG2207@1|root,COG2207@2|Bacteria,1MXT9@1224|Proteobacteria,2U0UP@28211|Alphaproteobacteria,2KHXI@204458|Caulobacterales 204458|Caulobacterales K PFAM helix-turn-helix- domain containing protein AraC type - - - - - - - - - - - - AraC_binding_2,HTH_18 k59_1718871_2 1123279.ATUS01000001_gene1423 1.24e-64 206.0 COG1305@1|root,COG1305@2|Bacteria,1MVAG@1224|Proteobacteria,1RMXM@1236|Gammaproteobacteria,1J91J@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Bacterial transglutaminase-like N-terminal region - - - - - - - - - - - - Bact_transglu_N,Transglut_core k59_1042107_1 1220534.B655_1723 1.7e-17 88.2 COG0399@1|root,arCOG00118@2157|Archaea,2XTRQ@28890|Euryarchaeota,23NU5@183925|Methanobacteria 183925|Methanobacteria E Belongs to the DegT DnrJ EryC1 family - - - - - - - - - - - - DegT_DnrJ_EryC1 k59_926688_1 1122137.AQXF01000003_gene2324 6.45e-136 409.0 COG0751@1|root,COG0751@2|Bacteria,1MV2F@1224|Proteobacteria,2TQKJ@28211|Alphaproteobacteria 28211|Alphaproteobacteria J Glycyl-tRNA synthetase beta subunit glyS - 6.1.1.14 ko:K01879 ko00970,map00970 M00360 R03654 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DALR_1,tRNA_synt_2f k59_588710_1 1056820.KB900632_gene2220 4.44e-12 68.9 COG0477@1|root,COG2814@2|Bacteria,1RAYJ@1224|Proteobacteria,1S7XJ@1236|Gammaproteobacteria,2PQ51@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria EGP Transmembrane secretion effector - - - - - - - - - - - - MFS_1,MFS_3 k59_588710_2 377629.TERTU_2479 4.28e-24 99.0 COG0566@1|root,COG0566@2|Bacteria,1MWCM@1224|Proteobacteria,1RY7P@1236|Gammaproteobacteria,2PN7E@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria J RNA 2'-O ribose methyltransferase substrate binding - - 2.1.1.185 ko:K03218 - - - - ko00000,ko01000,ko03009 - - - SpoU_methylase,SpoU_sub_bind k59_419096_1 1449355.JQNR01000004_gene1307 4.77e-86 273.0 COG1109@1|root,COG1109@2|Bacteria,2GJQA@201174|Actinobacteria 201174|Actinobacteria G the resulting product is then converted to GDP-mannose by ManC which is then used in the synthesis of mannose-containing glycoconjugates that are important for mediating entry into host cells manB - 5.4.2.8 ko:K01840 ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130 M00114 R01818 RC00408 ko00000,ko00001,ko00002,ko01000 - - - PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV k59_419096_2 1123376.AUIU01000011_gene1046 1.6e-17 75.9 COG1826@1|root,COG1826@2|Bacteria,3J1A4@40117|Nitrospirae 40117|Nitrospirae U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system - - - ko:K03116 ko03060,ko03070,map03060,map03070 M00336 - - ko00000,ko00001,ko00002,ko02044 2.A.64 - - MttA_Hcf106 k59_1549972_1 1205753.A989_17638 9.65e-06 52.0 COG1835@1|root,COG1835@2|Bacteria,1MV2W@1224|Proteobacteria,1RQS2@1236|Gammaproteobacteria,1X634@135614|Xanthomonadales 135614|Xanthomonadales I Acyltransferase family - - - - - - - - - - - - Acyl_transf_3 k59_756939_1 243159.AFE_3237 6.58e-23 99.4 COG2945@1|root,COG2945@2|Bacteria,1MUDY@1224|Proteobacteria,1S4MG@1236|Gammaproteobacteria,2NBWE@225057|Acidithiobacillales 225057|Acidithiobacillales S X-Pro dipeptidyl-peptidase (S15 family) - - - ko:K07018 - - - - ko00000 - - - Peptidase_S15 k59_1434854_1 404589.Anae109_3894 1.19e-119 356.0 COG0206@1|root,COG0206@2|Bacteria,1MV2X@1224|Proteobacteria,42MHK@68525|delta/epsilon subdivisions,2WJAZ@28221|Deltaproteobacteria,2YTTW@29|Myxococcales 28221|Deltaproteobacteria D Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity ftsZ - - ko:K03531 ko04112,map04112 - - - ko00000,ko00001,ko02048,ko03036,ko04812 - - - FtsZ_C,Tubulin k59_1434854_2 1232410.KI421421_gene3869 7.15e-62 204.0 COG0849@1|root,COG0849@2|Bacteria,1MUSR@1224|Proteobacteria,42MS2@68525|delta/epsilon subdivisions,2WIQ0@28221|Deltaproteobacteria,43SXW@69541|Desulfuromonadales 28221|Deltaproteobacteria D Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring ftsA - - ko:K03590 ko04112,map04112 - - - ko00000,ko00001,ko03036,ko04812 - - - FtsA,SHS2_FTSA k59_926695_1 1121396.KB893065_gene1609 9.64e-80 262.0 COG4249@1|root,COG4249@2|Bacteria,1MXS7@1224|Proteobacteria,43AXK@68525|delta/epsilon subdivisions,2X6BU@28221|Deltaproteobacteria,2MN2G@213118|Desulfobacterales 28221|Deltaproteobacteria S Caspase domain - - - - - - - - - - - - Peptidase_C14 k59_81558_1 272562.CA_C3687 1.5e-08 58.9 COG1309@1|root,COG1309@2|Bacteria,1VDC8@1239|Firmicutes,24M8R@186801|Clostridia,36KUE@31979|Clostridiaceae 186801|Clostridia K Bacterial regulatory proteins, tetR family - - - - - - - - - - - - TetR_N k59_192743_2 509190.Cseg_2726 1.48e-32 122.0 COG2266@1|root,COG2266@2|Bacteria,1RFQ8@1224|Proteobacteria,2U7WE@28211|Alphaproteobacteria,2KIEP@204458|Caulobacterales 204458|Caulobacterales H MobA-like NTP transferase domain - - - - - - - - - - - - NTP_transf_3 k59_588720_1 1026882.MAMP_00128 3.4e-94 300.0 COG0515@1|root,COG0631@1|root,COG0515@2|Bacteria,COG0631@2|Bacteria,1MV1P@1224|Proteobacteria,1RNQN@1236|Gammaproteobacteria,4603S@72273|Thiotrichales 72273|Thiotrichales KLT Serine/threonine phosphatases, family 2C, catalytic domain - - - - - - - - - - - - PP2C_2,Pkinase k59_530163_1 247156.NFA_19770 4.92e-26 109.0 COG1680@1|root,COG1680@2|Bacteria,2GJJB@201174|Actinobacteria,4FX3F@85025|Nocardiaceae 201174|Actinobacteria V Beta-lactamase - - - - - - - - - - - - Beta-lactamase k59_530163_2 1121937.AUHJ01000009_gene1569 1.54e-56 195.0 COG3320@1|root,COG4221@1|root,COG3320@2|Bacteria,COG4221@2|Bacteria,1QSHC@1224|Proteobacteria,1RQP8@1236|Gammaproteobacteria,465Q8@72275|Alteromonadaceae 1236|Gammaproteobacteria M dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes - - - - - - - - - - - - NAD_binding_4,adh_short k59_756946_1 158500.BV97_00633 3.67e-66 214.0 COG0303@1|root,COG0303@2|Bacteria,1MVD5@1224|Proteobacteria,2TQRI@28211|Alphaproteobacteria,2K1RP@204457|Sphingomonadales 204457|Sphingomonadales H molybdopterin biosynthesis moeA - 2.10.1.1 ko:K03750 ko00790,ko01100,map00790,map01100 - R09735 RC03462 ko00000,ko00001,ko01000 - - - MoCF_biosynth,MoeA_C,MoeA_N k59_1493688_1 702113.PP1Y_AT19299 7.11e-37 129.0 COG1214@1|root,COG1214@2|Bacteria,1MXPH@1224|Proteobacteria,2TTM2@28211|Alphaproteobacteria,2K59A@204457|Sphingomonadales 204457|Sphingomonadales O peptidase M22 - - - - - - - - - - - - Peptidase_M22 k59_1493688_2 702113.PP1Y_AT19306 1.52e-64 201.0 COG0694@1|root,COG0694@2|Bacteria,1MVQ1@1224|Proteobacteria,2TUD1@28211|Alphaproteobacteria,2K0IN@204457|Sphingomonadales 204457|Sphingomonadales O COG0694 Thioredoxin-like proteins and domains - - - - - - - - - - - - Nfu_N,NifU k59_419884_1 1283287.KB822577_gene3182 5.61e-16 83.2 COG4759@1|root,COG4759@2|Bacteria,2GRSQ@201174|Actinobacteria,4DRCX@85009|Propionibacteriales 201174|Actinobacteria O PFAM Sucraseferredoxin family protein - - - - - - - - - - - - Suc_Fer-like k59_757756_1 316407.1742783 9.78e-139 413.0 COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MU0R@1224|Proteobacteria,1RP3T@1236|Gammaproteobacteria,3XMCT@561|Escherichia 1236|Gammaproteobacteria G Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate ppsA GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006094,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008986,GO:0009058,GO:0009987,GO:0016051,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016781,GO:0019318,GO:0019319,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046364,GO:0046872,GO:0071704,GO:1901576 2.7.9.2 ko:K01007 ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200 M00173,M00374 R00199 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - iEcE24377_1341.EcE24377A_1919,iYL1228.KPN_02160 PEP-utilizers,PEP-utilizers_C,PPDK_N k59_927544_1 314225.ELI_06520 3.91e-08 52.8 COG0315@1|root,COG0315@2|Bacteria,1RCYZ@1224|Proteobacteria,2U747@28211|Alphaproteobacteria,2K4GG@204457|Sphingomonadales 204457|Sphingomonadales H Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP) moaC - 4.6.1.17 ko:K03637 ko00790,ko01100,ko04122,map00790,map01100,map04122 - R11372 RC03425 ko00000,ko00001,ko01000 - - - MoaC k59_645000_1 203122.Sde_2221 1.37e-41 146.0 COG0535@1|root,COG0535@2|Bacteria,1MU07@1224|Proteobacteria,1RN94@1236|Gammaproteobacteria,465Z3@72275|Alteromonadaceae 1236|Gammaproteobacteria S Protein of unknown function (DUF3641) - - - - - - - - - - - - DUF3641,Fer4_12,Radical_SAM k59_201954_1 1197477.IA57_02955 9.11e-79 258.0 COG4775@1|root,COG4775@2|Bacteria,4NE6Z@976|Bacteroidetes,1HWVA@117743|Flavobacteriia 976|Bacteroidetes M Outer membrane protein assembly yaeT - - ko:K07277 - - - - ko00000,ko02000,ko03029 1.B.33 - - Bac_surface_Ag,POTRA k59_34723_1 316407.1805559 2.23e-125 363.0 COG0150@1|root,COG0150@2|Bacteria,1MURG@1224|Proteobacteria,1RNZZ@1236|Gammaproteobacteria,3XP9U@561|Escherichia 1236|Gammaproteobacteria F Phosphoribosylformylglycinamidine cyclo-ligase purM GO:0003674,GO:0003824,GO:0004641,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016882,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.3.1 ko:K01933 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04208 RC01100 ko00000,ko00001,ko00002,ko01000 - - iECSF_1327.ECSF_2340 AIRS,AIRS_C k59_90822_1 1042377.AFPJ01000037_gene2964 4.44e-36 131.0 COG0671@1|root,COG0671@2|Bacteria,1RJ1T@1224|Proteobacteria,1SAU1@1236|Gammaproteobacteria,466ER@72275|Alteromonadaceae 1236|Gammaproteobacteria I COG0671 Membrane-associated phospholipid phosphatase - - 3.6.1.27 ko:K19302 ko00550,map00550 - R05627 RC00002 ko00000,ko00001,ko01000,ko01011 - - - PAP2 k59_90822_2 1190603.AJYD01000097_gene2426 1.19e-31 121.0 COG4671@1|root,COG4671@2|Bacteria,1QUFP@1224|Proteobacteria,1T1XC@1236|Gammaproteobacteria,1XTDK@135623|Vibrionales 135623|Vibrionales S COG1819 Glycosyl transferases, related to UDP-glucuronosyltransferase - - - - - - - - - - - - Glyco_trans_1_3 k59_201976_1 702113.PP1Y_AT4491 4.33e-63 216.0 COG1629@1|root,COG1629@2|Bacteria,COG4771@2|Bacteria,1MUWN@1224|Proteobacteria,2TUC0@28211|Alphaproteobacteria,2KD9E@204457|Sphingomonadales 204457|Sphingomonadales P Outer membrane protein beta-barrel family - - - - - - - - - - - - Plug,TonB_dep_Rec k59_1272836_1 1380347.JNII01000007_gene20 2.49e-88 297.0 COG2902@1|root,COG2902@2|Bacteria,2GK0C@201174|Actinobacteria,4ERD0@85013|Frankiales 201174|Actinobacteria E Dehydrogenase gdh - 1.4.1.2 ko:K15371 ko00220,ko00250,ko00430,ko00910,ko01100,map00220,map00250,map00430,map00910,map01100 - R00243 RC00006,RC02799 ko00000,ko00001,ko01000 - - - Bac_GDH k59_1727580_1 861299.J421_4449 1.21e-48 179.0 COG0515@1|root,COG0515@2|Bacteria,1ZTFJ@142182|Gemmatimonadetes 142182|Gemmatimonadetes KLT Serine/Threonine protein kinases, catalytic domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase k59_537018_1 436308.Nmar_0043 4.9e-115 340.0 COG0392@1|root,arCOG00899@2157|Archaea,41SFV@651137|Thaumarchaeota 651137|Thaumarchaeota S Lysylphosphatidylglycerol synthase TM region - - - ko:K07027 - - - - ko00000,ko02000 4.D.2 - - LPG_synthase_TM k59_1162664_2 573.JG24_27810 4.52e-10 60.5 COG3080@1|root,COG3080@2|Bacteria,1RDZD@1224|Proteobacteria,1S3W5@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane frdD GO:0000104,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006113,GO:0008150,GO:0008152,GO:0008177,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0016627,GO:0016635,GO:0031224,GO:0031226,GO:0032991,GO:0044237,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0045273,GO:0045274,GO:0045283,GO:0045284,GO:0045333,GO:0055114,GO:0070469,GO:0070470,GO:0071944,GO:0098796,GO:0098797,GO:0098803 - ko:K00247 ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020 M00009,M00011,M00150,M00173 R02164 RC00045 ko00000,ko00001,ko00002 - - iPC815.YPO0357,ic_1306.c5239 Fumarate_red_D k59_599191_2 1123270.ATUR01000006_gene189 2.29e-56 189.0 COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2TQR1@28211|Alphaproteobacteria,2K1ZD@204457|Sphingomonadales 204457|Sphingomonadales C belongs to the aldehyde dehydrogenase family - - 1.2.1.3 ko:K00128 ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130 M00135 R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146 RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_882748_1 933262.AXAM01000039_gene1146 5.07e-07 51.2 COG0492@1|root,COG0492@2|Bacteria,1MV15@1224|Proteobacteria,42MHR@68525|delta/epsilon subdivisions,2WIY8@28221|Deltaproteobacteria,2MJC5@213118|Desulfobacterales 28221|Deltaproteobacteria C Pyridine nucleotide-disulphide oxidoreductase trxB - 1.8.1.9 ko:K00384 ko00450,map00450 - R02016,R03596,R09372 RC00013,RC02518,RC02873 ko00000,ko00001,ko01000 - - - Pyr_redox_2 k59_882748_2 1047013.AQSP01000073_gene1101 1.27e-45 160.0 COG0281@1|root,COG0281@2|Bacteria,2NNV3@2323|unclassified Bacteria 2|Bacteria C Malic enzyme, NAD binding domain mez_1 - 1.1.1.38,1.1.1.40 ko:K00027,ko:K00029 ko00620,ko00710,ko01100,ko01120,ko01200,ko02020,map00620,map00710,map01100,map01120,map01200,map02020 M00169,M00172 R00214,R00216 RC00105 ko00000,ko00001,ko00002,ko01000 - - - Malic_M,malic k59_1561278_2 27923.ML051320a-PA 3.64e-09 65.1 COG0699@1|root,KOG0446@2759|Eukaryota,38C4B@33154|Opisthokonta,3B9RQ@33208|Metazoa 33208|Metazoa U BH2 domain binding - - 3.6.5.5 ko:K17065 ko04139,ko04214,ko04217,ko04621,ko04668,map04139,map04214,map04217,map04621,map04668 - - - ko00000,ko00001,ko01000,ko03029,ko04131,ko04147 - - - Dynamin_M,Dynamin_N,GED,WD40 k59_1391025_1 1121937.AUHJ01000004_gene1055 3.65e-57 200.0 COG2352@1|root,COG2352@2|Bacteria,1MUD5@1224|Proteobacteria,1RPTP@1236|Gammaproteobacteria,4646H@72275|Alteromonadaceae 1236|Gammaproteobacteria C Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle ppc GO:0003674,GO:0003824,GO:0004611,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0008964,GO:0009060,GO:0009987,GO:0015980,GO:0016829,GO:0016830,GO:0016831,GO:0016999,GO:0017144,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0055114,GO:0071704,GO:0072350 4.1.1.31 ko:K01595 ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200 M00168,M00170,M00171,M00172,M00173,M00346,M00374 R00345 RC02741 ko00000,ko00001,ko00002,ko01000 - - iSFV_1184.SFV_4025 PEPcase k59_822374_1 1280001.BAOA01000157_gene4761 2.42e-47 175.0 COG1640@1|root,COG1640@2|Bacteria,1QTVJ@1224|Proteobacteria,1RMJW@1236|Gammaproteobacteria,1XTQ7@135623|Vibrionales 135623|Vibrionales G 4-alpha-glucanotransferase malQ - 2.4.1.25 ko:K00705 ko00500,ko01100,map00500,map01100 - R05196 RC00049 ko00000,ko00001,ko01000 - GH77 - Glyco_hydro_77 k59_145247_1 436308.Nmar_0287 1.35e-144 412.0 COG0142@1|root,arCOG01727@2157|Archaea,41SC6@651137|Thaumarchaeota 651137|Thaumarchaeota H Belongs to the FPP GGPP synthase family - - 2.5.1.90 ko:K02523 ko00900,ko01110,map00900,map01110 - R09248 RC00279 ko00000,ko00001,ko01000,ko01006 - - - polyprenyl_synt k59_259704_1 523841.HFX_2974 1.74e-10 66.2 COG2358@1|root,arCOG01801@2157|Archaea,2XTR3@28890|Euryarchaeota,23S9X@183963|Halobacteria 183963|Halobacteria S TRAP transporter solute receptor, TAXI family imp - - ko:K07080 - - - - ko00000 - - - NMT1_3 k59_1615023_1 765912.Thimo_1143 3.58e-07 59.3 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1WXR1@135613|Chromatiales 135613|Chromatiales T Diguanylate cyclase - - - - - - - - - - - - EAL,GGDEF,PAS,PAS_4,dCache_3 k59_1219622_1 426117.M446_3652 9.16e-66 219.0 COG2225@1|root,COG2225@2|Bacteria,1MVEV@1224|Proteobacteria,2TS9R@28211|Alphaproteobacteria,1JS1F@119045|Methylobacteriaceae 28211|Alphaproteobacteria C Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA glcB GO:0000287,GO:0003674,GO:0003824,GO:0004474,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006082,GO:0008150,GO:0008152,GO:0009056,GO:0009436,GO:0009987,GO:0016054,GO:0016740,GO:0016746,GO:0019752,GO:0032787,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046185,GO:0046395,GO:0046487,GO:0046872,GO:0046912,GO:0071704,GO:0072329,GO:1901575 2.3.3.9 ko:K01638 ko00620,ko00630,ko01100,ko01110,ko01120,ko01200,map00620,map00630,map01100,map01110,map01120,map01200 M00012 R00472 RC00004,RC00308,RC02747 ko00000,ko00001,ko00002,ko01000 - - - Malate_synthase k59_1219622_2 627192.SLG_27960 3.79e-07 52.8 COG0477@1|root,COG2814@2|Bacteria,1MVQQ@1224|Proteobacteria,2TRBF@28211|Alphaproteobacteria 28211|Alphaproteobacteria EGP Major facilitator Superfamily - - - ko:K08195 - - - - ko00000,ko02000 2.A.1.15 - - MFS_1 k59_1162698_1 1123261.AXDW01000011_gene538 3.89e-16 84.3 COG2885@1|root,COG2885@2|Bacteria,1RKGT@1224|Proteobacteria,1S6ZQ@1236|Gammaproteobacteria,1X563@135614|Xanthomonadales 135614|Xanthomonadales M Belongs to the ompA family mopB - - ko:K03286 - - - - ko00000,ko02000 1.B.6 - - OMP_b-brl,OmpA,TSP_3 k59_481897_1 865937.Gilli_3437 3.59e-27 110.0 COG0486@1|root,COG0486@2|Bacteria,4NECT@976|Bacteroidetes,1HWWM@117743|Flavobacteriia,2P6FZ@244698|Gillisia 976|Bacteroidetes S MnmE helical domain mnmE - - ko:K03650 - - R08701 RC00053,RC00209,RC00870 ko00000,ko01000,ko03016 - - - MMR_HSR1,MnmE_helical,TrmE_N k59_1561307_1 1122137.AQXF01000003_gene2256 5.3e-38 136.0 COG0332@1|root,COG0332@2|Bacteria,1MU9N@1224|Proteobacteria,2TU94@28211|Alphaproteobacteria 28211|Alphaproteobacteria I COG0332 3-oxoacyl- acyl-carrier-protein synthase III fabH_2 - 2.3.1.207 ko:K16872 - - - - ko00000,ko01000 - - - ACP_syn_III,ACP_syn_III_C k59_1561307_2 1211112.ALJC01000094_gene1570 2.69e-24 101.0 COG0332@1|root,COG0332@2|Bacteria,1MU9N@1224|Proteobacteria,1RNIR@1236|Gammaproteobacteria 1236|Gammaproteobacteria I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids fabH - 2.3.1.207 ko:K16872 - - - - ko00000,ko01000 - - - ACP_syn_III,ACP_syn_III_C k59_426407_1 1357272.AVEO02000192_gene9 9.67e-80 243.0 COG4674@1|root,COG4674@2|Bacteria,1MUBR@1224|Proteobacteria,1RM8F@1236|Gammaproteobacteria,1Z8ZX@136849|Pseudomonas syringae group 1236|Gammaproteobacteria S Branched-chain amino acid ATP-binding cassette transporter livG - - ko:K11962 ko02010,map02010 M00323 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4.4,3.A.1.4.5 - - ABC_tran,BCA_ABC_TP_C k59_426407_2 1005048.CFU_2926 2.22e-72 224.0 COG0410@1|root,COG0410@2|Bacteria,1MU4Z@1224|Proteobacteria,2VJUP@28216|Betaproteobacteria,476J1@75682|Oxalobacteraceae 28216|Betaproteobacteria E ATPases associated with a variety of cellular activities - - - ko:K11963 ko02010,map02010 M00323 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4.4,3.A.1.4.5 - - ABC_tran k59_599239_1 744980.TRICHSKD4_5792 1.2e-42 151.0 COG2826@1|root,COG2826@2|Bacteria,1PP49@1224|Proteobacteria,2TRVA@28211|Alphaproteobacteria 28211|Alphaproteobacteria L COG2826 Transposase and inactivated derivatives, IS30 family - - - - - - - - - - - - HTH_38,rve k59_259738_1 1530186.JQEY01000028_gene14 4.18e-13 68.2 COG2801@1|root,COG2801@2|Bacteria,1MVXQ@1224|Proteobacteria,2TU72@28211|Alphaproteobacteria 28211|Alphaproteobacteria L COG2801 Transposase and inactivated derivatives - - - - - - - - - - - - HTH_21,rve,rve_3 k59_259738_2 318586.Pden_3161 3.23e-34 120.0 COG2963@1|root,COG2963@2|Bacteria,1N1AA@1224|Proteobacteria,2UC5K@28211|Alphaproteobacteria,2PXBD@265|Paracoccus 28211|Alphaproteobacteria L PFAM transposase IS3 IS911 family protein - - - - - - - - - - - - HTH_Tnp_1 k59_1561322_1 555793.WSK_2892 2.35e-104 306.0 COG2003@1|root,COG2003@2|Bacteria,1MXZ5@1224|Proteobacteria,2TQXM@28211|Alphaproteobacteria,2K0WQ@204457|Sphingomonadales 204457|Sphingomonadales L Belongs to the UPF0758 family radC - - ko:K03630 - - - - ko00000 - - - RadC k59_989859_1 1121403.AUCV01000003_gene1783 2.75e-11 63.2 COG1364@1|root,COG1364@2|Bacteria,1MU0T@1224|Proteobacteria,42M6S@68525|delta/epsilon subdivisions,2WJU8@28221|Deltaproteobacteria,2MIPX@213118|Desulfobacterales 28221|Deltaproteobacteria E Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate argJ GO:0003674,GO:0003824,GO:0004042,GO:0004358,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006592,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.3.1.1,2.3.1.35 ko:K00620 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028 R00259,R02282 RC00004,RC00064 ko00000,ko00001,ko00002,ko01000 - - - ArgJ k59_34803_1 436229.JOEH01000027_gene2222 2.88e-54 181.0 COG0673@1|root,COG0673@2|Bacteria,2GKW0@201174|Actinobacteria,2NGV6@228398|Streptacidiphilus 201174|Actinobacteria S Oxidoreductase family, NAD-binding Rossmann fold - - - - - - - - - - - - GFO_IDH_MocA,GFO_IDH_MocA_C k59_90873_1 1205753.A989_18948 8.56e-100 297.0 COG1305@1|root,COG1305@2|Bacteria,1MWAI@1224|Proteobacteria,1RRMA@1236|Gammaproteobacteria,1X788@135614|Xanthomonadales 135614|Xanthomonadales E Transglutaminase-like superfamily - - - - - - - - - - - - Bact_transglu_N,Transglut_core k59_822414_1 247634.GPB2148_761 2.7e-44 159.0 COG1502@1|root,COG1502@2|Bacteria,1MUDJ@1224|Proteobacteria,1RMIF@1236|Gammaproteobacteria 1236|Gammaproteobacteria I COG1502 Phosphatidylserine phosphatidylglycerophosphate cardiolipi n synthases and related enzymes - - - ko:K06132 ko00564,ko01100,map00564,map01100 - R11062 RC00017 ko00000,ko00001,ko01000 - - - PLDc_2 k59_426411_1 502025.Hoch_3544 1.18e-67 221.0 COG0482@1|root,COG0482@2|Bacteria,1MUT1@1224|Proteobacteria,42MZR@68525|delta/epsilon subdivisions,2WK6B@28221|Deltaproteobacteria,2YUTU@29|Myxococcales 28221|Deltaproteobacteria J Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 mnmA - 2.8.1.13 ko:K00566 ko04122,map04122 - R08700 RC02313,RC02315 ko00000,ko00001,ko01000,ko03016 - - - tRNA_Me_trans k59_712376_1 316407.85676685 1.54e-156 441.0 COG3954@1|root,COG3954@2|Bacteria,1MWN9@1224|Proteobacteria,1RMS7@1236|Gammaproteobacteria,3XNV0@561|Escherichia 1236|Gammaproteobacteria F phosphoribulokinase activity prkB GO:0003674,GO:0003824,GO:0004849,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006206,GO:0006213,GO:0006220,GO:0006221,GO:0006222,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008655,GO:0009058,GO:0009112,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009173,GO:0009174,GO:0009218,GO:0009220,GO:0009224,GO:0009259,GO:0009260,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018130,GO:0019205,GO:0019206,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0043094,GO:0043097,GO:0043174,GO:0043771,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046035,GO:0046049,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.7.1.19 ko:K00855 ko00710,ko01100,ko01120,ko01200,map00710,map01100,map01120,map01200 M00165,M00166 R01523 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - PRK k59_374460_1 501479.ACNW01000048_gene330 2.42e-76 243.0 COG0427@1|root,COG0427@2|Bacteria,1MUGE@1224|Proteobacteria,2TQYS@28211|Alphaproteobacteria 28211|Alphaproteobacteria C acetyl-CoA hydrolase - - 2.8.3.18,3.1.2.1 ko:K01067,ko:K18118 ko00020,ko00620,ko00650,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00650,map01100,map01110,map01120,map01130,map01200 M00009,M00011 R00227,R10343 RC00004,RC00012,RC00014 ko00000,ko00001,ko00002,ko01000 - - - AcetylCoA_hyd_C,AcetylCoA_hydro k59_1669816_1 335541.Swol_1498 6.96e-65 212.0 COG0541@1|root,COG0541@2|Bacteria,1TP06@1239|Firmicutes,248EU@186801|Clostridia,42JQN@68298|Syntrophomonadaceae 186801|Clostridia U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY ffh - 3.6.5.4 ko:K03106 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko01000,ko02044 3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9 - - SRP54,SRP54_N,SRP_SPB k59_1104155_1 316407.85676741 1.15e-143 415.0 COG0201@1|root,COG0201@2|Bacteria,1MVU7@1224|Proteobacteria,1RNJV@1236|Gammaproteobacteria,3XNT2@561|Escherichia 1236|Gammaproteobacteria U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently secY GO:0002790,GO:0003674,GO:0005048,GO:0005215,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006605,GO:0006612,GO:0006613,GO:0006614,GO:0006616,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0016043,GO:0022857,GO:0022884,GO:0031224,GO:0031226,GO:0031522,GO:0032940,GO:0032978,GO:0032991,GO:0033036,GO:0033218,GO:0033365,GO:0034613,GO:0042277,GO:0042886,GO:0042887,GO:0043952,GO:0044425,GO:0044459,GO:0044464,GO:0045047,GO:0045184,GO:0046903,GO:0046907,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0061024,GO:0065002,GO:0070727,GO:0070972,GO:0071702,GO:0071705,GO:0071806,GO:0071840,GO:0071944,GO:0072594,GO:0072599,GO:0072657,GO:0090150,GO:1904680 - ko:K03076 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5 - - SecY k59_426414_1 1122137.AQXF01000001_gene3375 3.41e-62 193.0 COG0290@1|root,COG0290@2|Bacteria,1RDD2@1224|Proteobacteria,2U58Z@28211|Alphaproteobacteria 28211|Alphaproteobacteria J IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins infC GO:0003674,GO:0003676,GO:0003723,GO:0003743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006413,GO:0006518,GO:0006807,GO:0006996,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016043,GO:0019538,GO:0022411,GO:0032790,GO:0032984,GO:0032988,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903008 - ko:K02520 - - - - ko00000,ko03012,ko03029 - - - IF3_C,IF3_N k59_426414_2 291985.CCSI01000002_gene1573 1.16e-32 127.0 COG0441@1|root,COG0441@2|Bacteria,1MUP2@1224|Proteobacteria,2TQWI@28211|Alphaproteobacteria,2K14B@204457|Sphingomonadales 204457|Sphingomonadales J Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) thrS - 6.1.1.3 ko:K01868 ko00970,map00970 M00359,M00360 R03663 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,TGS,tRNA-synt_2b,tRNA_SAD k59_822432_1 710696.Intca_0327 1.43e-59 203.0 COG1520@1|root,COG1520@2|Bacteria,2IAZ2@201174|Actinobacteria,4FIAP@85021|Intrasporangiaceae 201174|Actinobacteria S PQQ-like domain - - 1.1.2.6,2.7.11.1 ko:K05889,ko:K12132 - - R03136 - ko00000,ko01000,ko01001 - - - PQQ,PQQ_2,PQQ_3,Pkinase k59_882819_1 643562.Daes_2595 9.16e-35 125.0 COG1611@1|root,COG1611@2|Bacteria,1RD59@1224|Proteobacteria,42SVS@68525|delta/epsilon subdivisions,2WNMI@28221|Deltaproteobacteria,2MAYK@213115|Desulfovibrionales 28221|Deltaproteobacteria S Belongs to the LOG family - - 3.2.2.10 ko:K06966 ko00230,ko00240,map00230,map00240 - R00182,R00510 RC00063,RC00318 ko00000,ko00001,ko01000 - - - Lysine_decarbox k59_822433_1 1304883.KI912532_gene82 3.33e-10 62.4 COG3147@1|root,COG3147@2|Bacteria,1R7IV@1224|Proteobacteria,2VPE1@28216|Betaproteobacteria,2KWXH@206389|Rhodocyclales 206389|Rhodocyclales S Sporulation related domain - - - ko:K03749 - - - - ko00000 - - - SPOR k59_822433_2 379731.PST_1783 2.3e-20 89.7 COG1286@1|root,COG1286@2|Bacteria,1NF4G@1224|Proteobacteria,1RQ58@1236|Gammaproteobacteria,1Z0T0@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria S membrane protein, required for colicin V production cvpA GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008152,GO:0009058,GO:0009403,GO:0009404,GO:0009987,GO:0016020,GO:0019748,GO:0044237,GO:0044249,GO:0044464,GO:0044550,GO:0071944 - ko:K03558 - - - - ko00000 - - - Colicin_V k59_989876_1 640081.Dsui_3285 1.12e-22 106.0 COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2VP9Y@28216|Betaproteobacteria,2KVNY@206389|Rhodocyclales 206389|Rhodocyclales T Histidine kinase - - 2.7.13.3 ko:K02482 - - - - ko00000,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,HisKA,sCache_3_3 k59_989876_2 215803.DB30_2939 4.98e-26 102.0 COG0521@1|root,COG0521@2|Bacteria,1R9W2@1224|Proteobacteria,42R2A@68525|delta/epsilon subdivisions,2WMUK@28221|Deltaproteobacteria,2YVHG@29|Myxococcales 28221|Deltaproteobacteria H May be involved in the biosynthesis of molybdopterin moaB - 2.7.7.75 ko:K03638 ko00790,ko01100,map00790,map01100 - R09726 RC00002 ko00000,ko00001,ko01000 - - - MoCF_biosynth k59_1727645_1 1283300.ATXB01000001_gene1163 2.43e-82 257.0 COG4656@1|root,COG4656@2|Bacteria,1QTUI@1224|Proteobacteria,1RMIM@1236|Gammaproteobacteria,1XESP@135618|Methylococcales 135618|Methylococcales C Part of a membrane complex involved in electron transport - - - ko:K03615 - - - - ko00000 - - - Complex1_51K,Fer4_10,Fer4_7,RnfC_N,SLBB k59_1162760_1 502025.Hoch_1404 1.29e-67 231.0 COG0745@1|root,COG1352@1|root,COG2201@1|root,COG2202@1|root,COG2433@1|root,COG5002@1|root,COG0745@2|Bacteria,COG1352@2|Bacteria,COG2201@2|Bacteria,COG2202@2|Bacteria,COG2433@2|Bacteria,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,42NK9@68525|delta/epsilon subdivisions,2WMCQ@28221|Deltaproteobacteria 28221|Deltaproteobacteria T Response regulator receiver - - 2.1.1.80,3.1.1.61 ko:K13924 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko02022,ko02035 - - - CheB_methylest,CheR,CheR_N,GAF_2,HATPase_c,HisKA,PAS_10,PAS_3,PAS_4,PAS_9,Response_reg k59_1669839_1 1410620.SHLA_17c000700 3.85e-15 76.3 COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2U195@28211|Alphaproteobacteria,4BGQ2@82115|Rhizobiaceae 28211|Alphaproteobacteria T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA k59_1669839_2 857087.Metme_2958 4.69e-32 124.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,1XEJ5@135618|Methylococcales 135618|Methylococcales T Response regulator receiver - - - ko:K10943 ko02020,ko05111,map02020,map05111 M00515 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_1219668_1 1265313.HRUBRA_00325 1.35e-58 197.0 COG0028@1|root,COG0028@2|Bacteria,1MX6Q@1224|Proteobacteria,1RRJR@1236|Gammaproteobacteria 1236|Gammaproteobacteria EH Belongs to the TPP enzyme family mdlC - 4.1.1.7 ko:K01576 ko00627,ko01120,map00627,map01120 - R01764,R02672 RC00595 ko00000,ko00001,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_764296_1 443143.GM18_0429 3.93e-27 111.0 COG0115@1|root,COG0147@1|root,COG0115@2|Bacteria,COG0147@2|Bacteria,1MVBJ@1224|Proteobacteria,42P55@68525|delta/epsilon subdivisions,2WKYQ@28221|Deltaproteobacteria,43TCY@69541|Desulfuromonadales 28221|Deltaproteobacteria EH TIGRFAM para-aminobenzoate synthase, subunit I pabB - 2.6.1.85,4.1.3.38 ko:K01665,ko:K03342 ko00790,map00790 - R01716,R05553 RC00010,RC01418,RC01843,RC02148 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_4,Chorismate_bind k59_1615082_1 158500.BV97_02770 1.04e-38 137.0 COG1266@1|root,COG1266@2|Bacteria,1NN54@1224|Proteobacteria,2UUZE@28211|Alphaproteobacteria,2K77V@204457|Sphingomonadales 204457|Sphingomonadales S CAAX protease self-immunity - - - - - - - - - - - - Abi k59_1615082_2 702113.PP1Y_AT3403 2.79e-22 87.4 COG3750@1|root,COG3750@2|Bacteria,1N77J@1224|Proteobacteria,2UFX6@28211|Alphaproteobacteria,2K5Z1@204457|Sphingomonadales 204457|Sphingomonadales S Belongs to the UPF0335 family - - - - - - - - - - - - DUF2312 k59_34862_1 1144305.PMI02_01089 7.35e-46 159.0 COG0673@1|root,COG0673@2|Bacteria,1MVVF@1224|Proteobacteria,2TR6B@28211|Alphaproteobacteria,2K0ZG@204457|Sphingomonadales 204457|Sphingomonadales S Oxidoreductase family, C-terminal alpha/beta domain - - - - - - - - - - - - GFO_IDH_MocA,GFO_IDH_MocA_C k59_34862_2 158500.BV97_01675 4.7e-21 90.9 COG1082@1|root,COG1082@2|Bacteria,1R8Q2@1224|Proteobacteria,2U2U4@28211|Alphaproteobacteria,2K7UW@204457|Sphingomonadales 204457|Sphingomonadales G Xylose isomerase-like TIM barrel - - - - - - - - - - - - AP_endonuc_2 k59_481950_1 1122137.AQXF01000005_gene1315 1.02e-25 103.0 COG0834@1|root,COG0834@2|Bacteria 2|Bacteria ET amino acid transport - - - ko:K02030 - M00236 - - ko00000,ko00002,ko02000 3.A.1.3 - - SBP_bac_3 k59_1220535_1 208439.AJAP_23335 1.73e-22 96.7 COG0657@1|root,COG0657@2|Bacteria,2IE8R@201174|Actinobacteria,4EBQ1@85010|Pseudonocardiales 201174|Actinobacteria I alpha/beta hydrolase fold - - - - - - - - - - - - Abhydrolase_3 k59_1220535_2 497321.C664_09660 2.16e-12 67.4 COG0529@1|root,COG2895@1|root,COG0529@2|Bacteria,COG2895@2|Bacteria,1MUD9@1224|Proteobacteria,2VHYV@28216|Betaproteobacteria,2KVRC@206389|Rhodocyclales 206389|Rhodocyclales H Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN NodQ subfamily cysC - 2.7.1.25,2.7.7.4 ko:K00955 ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130 M00176 R00509,R00529,R04928,R04929 RC00002,RC00078,RC02809,RC02889 ko00000,ko00001,ko00002,ko01000 - - - APS_kinase,GTP_EFTU k59_1105106_1 316407.85675007 4.76e-143 413.0 COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,1RMBQ@1236|Gammaproteobacteria,3XNDH@561|Escherichia 1236|Gammaproteobacteria C Catalyzes the NAD( )-dependent oxidation of succinate semialdehyde to succinate. It acts preferentially with NAD as cosubstrate but can also use NADP. Prevents the toxic accumulation of succinate semialdehyde (SSA) and plays an important role when arginine and putrescine are used as the sole nitrogen or carbon sources yneI GO:0001505,GO:0003674,GO:0003824,GO:0004777,GO:0006082,GO:0006520,GO:0006525,GO:0006527,GO:0006576,GO:0006595,GO:0006598,GO:0006807,GO:0008150,GO:0008152,GO:0009013,GO:0009056,GO:0009063,GO:0009064,GO:0009065,GO:0009308,GO:0009310,GO:0009445,GO:0009447,GO:0009448,GO:0009450,GO:0009987,GO:0016054,GO:0016491,GO:0016620,GO:0016903,GO:0019752,GO:0032787,GO:0034641,GO:0042133,GO:0042135,GO:0042402,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0055114,GO:0065007,GO:0065008,GO:0071704,GO:0072329,GO:0097164,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 1.2.1.16,1.2.1.20,1.2.1.24,1.2.1.79 ko:K00135,ko:K08324 ko00250,ko00310,ko00350,ko00650,ko00760,ko01100,ko01120,map00250,map00310,map00350,map00650,map00760,map01100,map01120 M00027 R00713,R00714,R02401 RC00080 ko00000,ko00001,ko00002,ko01000 - - iECUMN_1333.ECUMN_1793 Aldedh k59_1780831_1 1122137.AQXF01000001_gene2709 4.05e-214 603.0 COG4962@1|root,COG4962@2|Bacteria,1R7EN@1224|Proteobacteria,2TRNT@28211|Alphaproteobacteria 28211|Alphaproteobacteria U pilus assembly protein ATPase CpaF - - - ko:K02283 - - - - ko00000,ko02035,ko02044 - - - T2SSE k59_1780831_2 1122137.AQXF01000001_gene2710 1.67e-119 353.0 COG4965@1|root,COG4965@2|Bacteria,1MUXK@1224|Proteobacteria,2TRBI@28211|Alphaproteobacteria 28211|Alphaproteobacteria U Pilus assembly protein tadB - - ko:K12510 - - - - ko00000,ko02044 - - - T2SSF k59_1105107_1 436308.Nmar_0315 5.47e-78 241.0 COG1577@1|root,arCOG01028@2157|Archaea,41SKC@651137|Thaumarchaeota 651137|Thaumarchaeota I Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids mvk - 2.7.1.36 ko:K00869 ko00900,ko01100,ko01110,ko01130,ko04146,map00900,map01100,map01110,map01130,map04146 M00095 R02245 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - GHMP_kinases_C,GHMP_kinases_N k59_1105107_2 1229909.NSED_00885 1.89e-18 82.4 COG1355@1|root,arCOG01728@2157|Archaea,41S9D@651137|Thaumarchaeota 651137|Thaumarchaeota S Belongs to the MEMO1 family - - - ko:K06990 - - - - ko00000,ko04812 - - - Memo k59_1330648_1 511145.b1296 8.52e-139 402.0 COG0531@1|root,COG0531@2|Bacteria,1MXNJ@1224|Proteobacteria,1RMKV@1236|Gammaproteobacteria,3XQ7N@561|Escherichia 1236|Gammaproteobacteria E putrescine transmembrane transporter activity puuP GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006576,GO:0006595,GO:0006598,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0006928,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008324,GO:0008519,GO:0009056,GO:0009308,GO:0009310,GO:0009445,GO:0009447,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015101,GO:0015203,GO:0015291,GO:0015293,GO:0015294,GO:0015295,GO:0015318,GO:0015489,GO:0015672,GO:0015695,GO:0015696,GO:0015846,GO:0015847,GO:0016020,GO:0022804,GO:0022857,GO:0022890,GO:0033554,GO:0034220,GO:0034641,GO:0040011,GO:0042402,GO:0044106,GO:0044237,GO:0044464,GO:0048870,GO:0050896,GO:0051179,GO:0051234,GO:0051674,GO:0051716,GO:0055085,GO:0071702,GO:0071704,GO:0071705,GO:0071944,GO:0072488,GO:0097164,GO:0098655,GO:0098660,GO:0098662,GO:1901564,GO:1901565,GO:1901575,GO:1902047,GO:1902600 - ko:K14052 - - - - ko00000,ko02000 2.A.3.1.13 - iSBO_1134.SBO_1766 AA_permease k59_600619_1 391603.FBALC1_04732 1.01e-17 83.6 2DBC9@1|root,2Z8CA@2|Bacteria,4NJS4@976|Bacteroidetes,1HYBG@117743|Flavobacteriia 976|Bacteroidetes S Domain of unknown function (DUF4173) - - - - - - - - - - - - DUF4173 k59_319260_2 436308.Nmar_0558 9.37e-55 182.0 arCOG08027@1|root,arCOG08027@2157|Archaea,41T8U@651137|Thaumarchaeota 2157|Archaea D Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity - - - ko:K22222 - - - - ko00000,ko04812 - - - - k59_652881_1 1229909.NSED_03795 5.21e-99 300.0 arCOG08801@1|root,arCOG08801@2157|Archaea 2157|Archaea S Metal dependent phosphohydrolases with conserved 'HD' motif. - - - - - - - - - - - - - k59_935257_1 632518.Calow_0520 3.38e-05 51.6 COG0493@1|root,COG0493@2|Bacteria,1TQ1A@1239|Firmicutes,248EK@186801|Clostridia,42EUY@68295|Thermoanaerobacterales 186801|Clostridia C PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase gltA - 1.4.1.13,1.4.1.14 ko:K00266 ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 - R00093,R00114,R00248 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - Fer4_20,Pyr_redox_2 k59_1392395_1 1122197.ATWI01000009_gene1950 1.57e-64 207.0 COG0583@1|root,COG0583@2|Bacteria,1MWVU@1224|Proteobacteria,1RPT8@1236|Gammaproteobacteria,465VQ@72275|Alteromonadaceae 1236|Gammaproteobacteria K Transcriptional regulator finR - - - - - - - - - - - HTH_1,LysR_substrate k59_1220550_1 1392493.JIAB01000001_gene691 3.26e-56 201.0 COG0488@1|root,COG0488@2|Bacteria,1TPAX@1239|Firmicutes,247U6@186801|Clostridia,27JZ5@186928|unclassified Lachnospiraceae 186801|Clostridia S ABC transporter C-terminal domain - - - ko:K06158 - - - - ko00000,ko03012 - - - ABC_tran,ABC_tran_CTD,ABC_tran_Xtn k59_1392398_1 1122137.AQXF01000001_gene3269 1.82e-86 259.0 2BGD9@1|root,32AAZ@2|Bacteria,1RJNC@1224|Proteobacteria,2U9WN@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_375795_1 203122.Sde_0774 1.5e-82 259.0 COG2160@1|root,COG2160@2|Bacteria,1MW0J@1224|Proteobacteria,1RQEF@1236|Gammaproteobacteria,4669F@72275|Alteromonadaceae 1236|Gammaproteobacteria G L-arabinose isomerase C-terminal domain araA GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008733,GO:0009056,GO:0009058,GO:0009987,GO:0016052,GO:0016853,GO:0016860,GO:0016861,GO:0019321,GO:0019323,GO:0019566,GO:0019568,GO:0019569,GO:0019572,GO:0019637,GO:0044237,GO:0044238,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046373,GO:0051167,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901159,GO:1901575,GO:1901576 5.3.1.4 ko:K01804 ko00040,ko01100,map00040,map01100 - R01761 RC00516 ko00000,ko00001,ko01000 - - iAPECO1_1312.APECO1_1922,iB21_1397.B21_00063,iBWG_1329.BWG_0058,iE2348C_1286.E2348C_0063,iECBD_1354.ECBD_3555,iECD_1391.ECD_00064,iECED1_1282.ECED1_0061,iECIAI1_1343.ECIAI1_0062,iECNA114_1301.ECNA114_0050,iECO103_1326.ECO103_0063,iECO26_1355.ECO26_0064,iECOK1_1307.ECOK1_0061,iECP_1309.ECP_0063,iECS88_1305.ECS88_0065,iECSE_1348.ECSE_0062,iECW_1372.ECW_m0060,iEKO11_1354.EKO11_3852,iEcE24377_1341.EcE24377A_0064,iEcHS_1320.EcHS_A0066,iEcSMS35_1347.EcSMS35_0064,iEcolC_1368.EcolC_3595,iLF82_1304.LF82_0105,iNRG857_1313.NRG857_00320,iSBO_1134.SBO_0049,iSSON_1240.SSON_0068,iUMN146_1321.UM146_23095,iUTI89_1310.UTI89_C0067,iWFL_1372.ECW_m0060 Arabinose_Iso_C,Arabinose_Isome k59_1728617_1 1286093.C266_08872 6.19e-47 166.0 COG1565@1|root,COG1565@2|Bacteria,1N3CJ@1224|Proteobacteria,2VHBE@28216|Betaproteobacteria,1K3UE@119060|Burkholderiaceae 28216|Betaproteobacteria S Putative S-adenosyl-L-methionine-dependent methyltransferase - - - - - - - - - - - - Methyltransf_28 k59_1105129_1 502025.Hoch_4147 2.57e-55 194.0 COG1529@1|root,COG2080@1|root,COG1529@2|Bacteria,COG2080@2|Bacteria,1MUEA@1224|Proteobacteria,42MER@68525|delta/epsilon subdivisions,2WIYV@28221|Deltaproteobacteria,2YW7P@29|Myxococcales 28221|Deltaproteobacteria C Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding - - 1.2.5.3 ko:K03520 - - R11168 RC02800 ko00000,ko01000 - - - Ald_Xan_dh_C,Ald_Xan_dh_C2,Fer2,Fer2_2 k59_600634_1 876044.IMCC3088_1671 4.24e-15 80.1 COG1629@1|root,COG4771@2|Bacteria,1MWKN@1224|Proteobacteria,1T3IM@1236|Gammaproteobacteria,1JC1N@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P TonB dependent receptor - - - - - - - - - - - - Plug,TonB_dep_Rec k59_944180_1 640081.Dsui_1458 1.86e-49 164.0 COG2062@1|root,COG2062@2|Bacteria,1RIVH@1224|Proteobacteria,2VSSQ@28216|Betaproteobacteria,2KWCC@206389|Rhodocyclales 206389|Rhodocyclales T phosphohistidine phosphatase, SixA sixA - - ko:K08296 - - - - ko00000,ko01000 - - - His_Phos_1 k59_662206_1 158500.BV97_02447 3.34e-90 280.0 COG2244@1|root,COG2244@2|Bacteria,1PDRG@1224|Proteobacteria,2TVKM@28211|Alphaproteobacteria,2K0P5@204457|Sphingomonadales 204457|Sphingomonadales S Polysaccharide biosynthesis protein - - - - - - - - - - - - Polysacc_synt,Polysacc_synt_3 k59_491689_2 1178825.ALIH01000001_gene2667 8.16e-35 134.0 COG0341@1|root,COG0342@1|root,COG0341@2|Bacteria,COG0342@2|Bacteria,4NE1X@976|Bacteroidetes,1HY03@117743|Flavobacteriia 976|Bacteroidetes U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA secD - - ko:K03072,ko:K12257 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 2.A.6.4,3.A.5.2,3.A.5.7 - - SecD_SecF,Sec_GG k59_1624386_1 392499.Swit_3633 5.89e-88 271.0 COG1960@1|root,COG1960@2|Bacteria,1MVJC@1224|Proteobacteria,2U1UJ@28211|Alphaproteobacteria,2K150@204457|Sphingomonadales 204457|Sphingomonadales I acyl-CoA dehydrogenase - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_384855_1 1121441.AUCX01000016_gene2330 1.28e-11 70.1 2DSUH@1|root,33HGK@2|Bacteria,1NHJH@1224|Proteobacteria,436EN@68525|delta/epsilon subdivisions,2X103@28221|Deltaproteobacteria,2MDWP@213115|Desulfovibrionales 28221|Deltaproteobacteria S Sulfotransferase family - - - - - - - - - - - - Sulfotransfer_2 k59_547097_1 926560.KE387027_gene866 1.11e-22 101.0 COG3345@1|root,COG3345@2|Bacteria,1WIV5@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus G Melibiase - - 3.2.1.22 ko:K07407 ko00052,ko00561,ko00600,ko00603,map00052,map00561,map00600,map00603 - R01101,R01103,R01104,R01194,R01329,R02926,R03634,R04019,R04470,R05549,R05961,R06091 RC00049,RC00059,RC00451 ko00000,ko00001,ko01000 - - - Melibiase k59_773893_1 330214.NIDE0325 1.48e-62 206.0 COG1236@1|root,COG1236@2|Bacteria,3J0FD@40117|Nitrospirae 40117|Nitrospirae J Beta-Casp domain - - - ko:K07576 - - - - ko00000 - - - Beta-Casp,Lactamase_B,RMMBL k59_944200_1 1415780.JPOG01000001_gene2924 3.92e-12 71.2 2DKFZ@1|root,309D6@2|Bacteria,1REQQ@1224|Proteobacteria,1S796@1236|Gammaproteobacteria,1X7WC@135614|Xanthomonadales 135614|Xanthomonadales S Domain of unknown function (DUF4382) - - - - - - - - - - - - DUF4382 k59_1736999_1 865937.Gilli_1247 4.68e-19 85.9 COG1228@1|root,COG1228@2|Bacteria,4NFI3@976|Bacteroidetes,1HY2V@117743|Flavobacteriia,2P5C8@244698|Gillisia 976|Bacteroidetes Q Amidohydrolase family - - - - - - - - - - - - Amidohydro_1 k59_1228770_1 640511.BC1002_5978 2.68e-17 81.3 COG2207@1|root,COG2207@2|Bacteria,1N0FA@1224|Proteobacteria,2VKR0@28216|Betaproteobacteria,1K2I8@119060|Burkholderiaceae 28216|Betaproteobacteria K Cupin - - - - - - - - - - - - Cupin_6,HTH_18 k59_1339195_1 443144.GM21_3824 7.5e-40 152.0 COG0457@1|root,COG3914@1|root,COG0457@2|Bacteria,COG3914@2|Bacteria,1MVMG@1224|Proteobacteria,42PJA@68525|delta/epsilon subdivisions,2WMG0@28221|Deltaproteobacteria,43TUT@69541|Desulfuromonadales 28221|Deltaproteobacteria O repeat-containing protein - - - - - - - - - - - - Glyco_transf_41,TPR_1,TPR_10,TPR_11,TPR_16,TPR_2,TPR_7,TPR_8 k59_547108_2 436308.Nmar_0482 1.95e-34 125.0 COG0581@1|root,arCOG00168@2157|Archaea,41SZ4@651137|Thaumarchaeota 651137|Thaumarchaeota P TIGRFAM phosphate ABC transporter - - - ko:K02038 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - BPD_transp_1 k59_832753_2 1167006.UWK_00899 5.92e-29 112.0 COG1778@1|root,COG1778@2|Bacteria,1RH85@1224|Proteobacteria,42SN2@68525|delta/epsilon subdivisions,2WP0X@28221|Deltaproteobacteria,2MPUR@213118|Desulfobacterales 28221|Deltaproteobacteria S haloacid dehalogenase-like hydrolase kdsC - 3.1.3.45 ko:K03270 ko00540,ko01100,map00540,map01100 M00063 R03350 RC00017 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Hydrolase_3 k59_1061214_1 1088721.NSU_0803 5.49e-07 49.7 COG1846@1|root,COG1846@2|Bacteria,1RHR0@1224|Proteobacteria,2UBPN@28211|Alphaproteobacteria,2KB0F@204457|Sphingomonadales 204457|Sphingomonadales K Bacterial regulatory protein, arsR family - - - - - - - - - - - - MarR_2 k59_1061214_2 702113.PP1Y_AT18347 3.25e-90 265.0 COG0080@1|root,COG0080@2|Bacteria,1RA2M@1224|Proteobacteria,2U760@28211|Alphaproteobacteria,2K3Z9@204457|Sphingomonadales 204457|Sphingomonadales J Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors rplK - - ko:K02867 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L11,Ribosomal_L11_N k59_1061214_3 1096930.L284_04045 0.000176 42.7 COG0081@1|root,COG0081@2|Bacteria,1MUE6@1224|Proteobacteria,2TRXP@28211|Alphaproteobacteria,2K0YM@204457|Sphingomonadales 204457|Sphingomonadales J Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release rplA - - ko:K02863 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L1 k59_723223_1 1121898.Q766_09335 1.74e-55 194.0 COG1048@1|root,COG1048@2|Bacteria,4NDZT@976|Bacteroidetes,1HWJV@117743|Flavobacteriia,2NUEC@237|Flavobacterium 976|Bacteroidetes C aconitate hydratase acnA - 4.2.1.3 ko:K01681 ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00173,M00740 R01324,R01325,R01900 RC00497,RC00498,RC00618 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase,Aconitase_C k59_1514423_1 1260251.SPISAL_07325 2.76e-44 158.0 COG0529@1|root,COG2046@1|root,COG0529@2|Bacteria,COG2046@2|Bacteria,1MX0D@1224|Proteobacteria,1RNWT@1236|Gammaproteobacteria,1X2EG@135613|Chromatiales 135613|Chromatiales P PUA-like domain - - 2.7.7.4 ko:K00958 ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130 M00176,M00596 R00529,R04929 RC02809,RC02889 ko00000,ko00001,ko00002,ko01000 - - - APS_kinase,ATP-sulfurylase,PUA_2 k59_100542_1 395964.KE386496_gene2006 4.33e-176 500.0 COG2710@1|root,COG2710@2|Bacteria,1MVY2@1224|Proteobacteria,2TU8M@28211|Alphaproteobacteria,3NAHQ@45404|Beijerinckiaceae 28211|Alphaproteobacteria C Nitrogenase component 1 type Oxidoreductase nifD - 1.18.6.1 ko:K02586 ko00625,ko00910,ko01100,ko01120,map00625,map00910,map01100,map01120 M00175 R05185,R05496 RC00002,RC01395,RC02891 ko00000,ko00001,ko00002,ko01000 - - - Oxidored_nitro k59_547121_1 1116369.KB890024_gene8 5.77e-26 106.0 COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2TQR1@28211|Alphaproteobacteria,43IYH@69277|Phyllobacteriaceae 28211|Alphaproteobacteria C Aldehyde dehydrogenase - - 1.2.1.16,1.2.1.20,1.2.1.79 ko:K00135 ko00250,ko00310,ko00350,ko00650,ko00760,ko01100,ko01120,map00250,map00310,map00350,map00650,map00760,map01100,map01120 M00027 R00713,R00714,R02401 RC00080 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_212285_1 436308.Nmar_0616 1.17e-51 184.0 arCOG08231@1|root,arCOG08231@2157|Archaea,41T6Q@651137|Thaumarchaeota 651137|Thaumarchaeota L Lamin Tail Domain - - - - - - - - - - - - LTD k59_1452662_1 349124.Hhal_1913 1.14e-33 119.0 COG1671@1|root,COG1671@2|Bacteria,1RCZA@1224|Proteobacteria,1S3QM@1236|Gammaproteobacteria,1WYBE@135613|Chromatiales 135613|Chromatiales S Belongs to the UPF0178 family - - - ko:K09768 - - - - ko00000 - - - DUF188 k59_1452662_2 755178.Cyan10605_2668 8.41e-46 151.0 COG3577@1|root,COG3577@2|Bacteria,1G6TW@1117|Cyanobacteria 1117|Cyanobacteria S Aspartyl protease - - - - - - - - - - - - gag-asp_proteas k59_328194_1 1123355.JHYO01000013_gene1161 2.16e-09 61.2 COG0834@1|root,COG0834@2|Bacteria,1MV5D@1224|Proteobacteria,2TSRF@28211|Alphaproteobacteria,36XDG@31993|Methylocystaceae 1224|Proteobacteria ET Bacterial periplasmic substrate-binding proteins - - - ko:K09969 ko02010,map02010 M00232 - - ko00000,ko00001,ko00002,ko02000 3.A.1.3.18,3.A.1.3.7,3.A.1.3.8 - - SBP_bac_3 k59_1789434_1 436308.Nmar_1416 1.32e-105 310.0 COG0020@1|root,arCOG01532@2157|Archaea,41S8J@651137|Thaumarchaeota 651137|Thaumarchaeota H Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids uppS - 2.5.1.89 ko:K15888 ko00900,map00900 - R09730 RC00279,RC02839 ko00000,ko00001,ko01000 - - - Prenyltransf k59_1679476_1 926567.TheveDRAFT_0578 1.14e-92 281.0 COG0050@1|root,COG0050@2|Bacteria,3T9PS@508458|Synergistetes 508458|Synergistetes J This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis tuf - - ko:K02358 - - - - ko00000,ko03012,ko03029,ko04147 - - - GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3 k59_491715_1 35754.JNYJ01000035_gene3839 4.66e-28 112.0 COG4249@1|root,COG4249@2|Bacteria,2IB3R@201174|Actinobacteria,4DIC8@85008|Micromonosporales 201174|Actinobacteria S Caspase domain - - - - - - - - - - - - PG_binding_1,Peptidase_C14 k59_491717_1 5741.EDO80217 4.4e-05 52.0 COG0417@1|root,KOG0969@2759|Eukaryota 2759|Eukaryota L DNA replication proofreading POLD1 GO:0000109,GO:0000228,GO:0000278,GO:0000723,GO:0000731,GO:0000781,GO:0000784,GO:0003674,GO:0003676,GO:0003677,GO:0003682,GO:0003684,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005657,GO:0005694,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006278,GO:0006281,GO:0006283,GO:0006284,GO:0006287,GO:0006289,GO:0006296,GO:0006297,GO:0006301,GO:0006401,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0007049,GO:0008150,GO:0008152,GO:0008296,GO:0008408,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009314,GO:0009411,GO:0009416,GO:0009628,GO:0009987,GO:0016043,GO:0016070,GO:0016234,GO:0016235,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0018130,GO:0019438,GO:0019439,GO:0019725,GO:0019899,GO:0019985,GO:0022402,GO:0022616,GO:0030894,GO:0031974,GO:0031981,GO:0032200,GO:0032201,GO:0032991,GO:0032993,GO:0033260,GO:0033554,GO:0033567,GO:0033683,GO:0034061,GO:0034641,GO:0034644,GO:0034645,GO:0034654,GO:0034655,GO:0042575,GO:0042592,GO:0042769,GO:0043137,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043596,GO:0043601,GO:0043625,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044271,GO:0044422,GO:0044424,GO:0044427,GO:0044428,GO:0044444,GO:0044446,GO:0044454,GO:0044464,GO:0044786,GO:0045004,GO:0045005,GO:0046483,GO:0046700,GO:0048878,GO:0050801,GO:0050896,GO:0051276,GO:0051606,GO:0051716,GO:0055081,GO:0055088,GO:0055089,GO:0060249,GO:0061695,GO:0065007,GO:0065008,GO:0070013,GO:0070914,GO:0071214,GO:0071478,GO:0071482,GO:0071704,GO:0071840,GO:0071897,GO:0090304,GO:0090305,GO:0097159,GO:0098687,GO:0104004,GO:0140097,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901575,GO:1901576,GO:1902296,GO:1902319,GO:1902494,GO:1902969,GO:1902983,GO:1903047,GO:1903459,GO:1904161,GO:1990234,GO:1990391 2.7.7.7 ko:K02327 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03430,ko03440,ko05166,map00230,map00240,map01100,map03030,map03410,map03420,map03430,map03440,map05166 M00262 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol_B,DNA_pol_B_exo1,zf-C4pol k59_44662_1 1121017.AUFG01000013_gene1904 8.51e-62 204.0 COG3033@1|root,COG3033@2|Bacteria,2GKH3@201174|Actinobacteria,4FIW0@85021|Intrasporangiaceae 201174|Actinobacteria E Beta-eliminating lyase tpl - 4.1.99.1,4.1.99.2 ko:K01667,ko:K01668 ko00350,ko00380,map00350,map00380 - R00673,R00728 RC00209,RC00355,RC00364 ko00000,ko00001,ko01000 - - - Beta_elim_lyase k59_609900_2 1144305.PMI02_01710 2.6e-06 49.7 COG0436@1|root,COG0436@2|Bacteria,1R3UB@1224|Proteobacteria,2U497@28211|Alphaproteobacteria,2KCR1@204457|Sphingomonadales 204457|Sphingomonadales E Aminotransferase - - - - - - - - - - - - Aminotran_1_2 k59_384902_1 936455.KI421499_gene6816 2.58e-42 149.0 COG0592@1|root,COG0592@2|Bacteria,1MVD9@1224|Proteobacteria,2TSRZ@28211|Alphaproteobacteria,3JUE8@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria L Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria dnaN - 2.7.7.7 ko:K02338 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_beta,DNA_pol3_beta_2,DNA_pol3_beta_3 k59_384902_2 990285.RGCCGE502_00450 1.23e-20 92.8 COG1195@1|root,COG1195@2|Bacteria,1MX8N@1224|Proteobacteria,2TQRD@28211|Alphaproteobacteria,4B79E@82115|Rhizobiaceae 28211|Alphaproteobacteria L it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP recF - - ko:K03629 ko03440,map03440 - - - ko00000,ko00001,ko03400 - - - AAA_21,AAA_23,SMC_N k59_1339241_2 1122137.AQXF01000007_gene3499 2.65e-05 45.1 COG5000@1|root,COG5000@2|Bacteria,1MWKZ@1224|Proteobacteria 1224|Proteobacteria T signal transduction histidine kinase - - 2.7.13.3 ko:K07709 ko02020,map02020 M00499 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA,PAS,PAS_8 k59_1789444_1 1219035.NT2_01_05850 1.24e-72 244.0 COG1629@1|root,COG4771@2|Bacteria,1MWKN@1224|Proteobacteria,2U131@28211|Alphaproteobacteria,2K3GH@204457|Sphingomonadales 204457|Sphingomonadales P TonB dependent receptor - - - - - - - - - - - - Plug,TonB_dep_Rec k59_384914_2 1121428.DESHY_160050___1 7.75e-14 74.7 COG1484@1|root,COG4584@1|root,COG1484@2|Bacteria,COG4584@2|Bacteria,1TPPI@1239|Firmicutes,24DKZ@186801|Clostridia,263ME@186807|Peptococcaceae 186801|Clostridia L PFAM IstB-like ATP binding protein - - - - - - - - - - - - IstB_IS21 k59_44680_1 1122137.AQXF01000004_gene1434 1.25e-66 207.0 COG2151@1|root,COG2151@2|Bacteria,1MZ9Y@1224|Proteobacteria,2U72U@28211|Alphaproteobacteria 28211|Alphaproteobacteria S FeS assembly SUF system protein mrp - - - - - - - - - - - FeS_assembly_P k59_44680_2 1122137.AQXF01000004_gene1433 0.000768 40.0 COG0316@1|root,COG0316@2|Bacteria,1RH6T@1224|Proteobacteria,2UBWJ@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Belongs to the HesB IscA family iscA GO:0003674,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008198,GO:0009058,GO:0009987,GO:0010467,GO:0016043,GO:0016226,GO:0018130,GO:0019438,GO:0019538,GO:0022607,GO:0031163,GO:0031974,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046148,GO:0046483,GO:0046872,GO:0046914,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051537,GO:0051540,GO:0051604,GO:0070013,GO:0071704,GO:0071840,GO:0097428,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 - ko:K13628 - - - - ko00000,ko03016 - - - Fe-S_biosyn k59_384918_1 1123270.ATUR01000006_gene206 9.08e-66 219.0 COG1053@1|root,COG1053@2|Bacteria,1MURY@1224|Proteobacteria,2U47P@28211|Alphaproteobacteria,2KD4F@204457|Sphingomonadales 204457|Sphingomonadales C FAD binding domain - - 1.3.99.4 ko:K05898 ko00984,ko01100,ko01120,map00984,map01100,map01120 - R09884 RC00991 ko00000,ko00001,ko01000 - - - FAD_binding_2 k59_894447_2 469371.Tbis_0330 1.74e-08 57.0 COG1846@1|root,COG1846@2|Bacteria,2IQNM@201174|Actinobacteria,4E61C@85010|Pseudonocardiales 201174|Actinobacteria K helix_turn_helix multiple antibiotic resistance protein - - - - - - - - - - - - MarR,MarR_2 k59_213330_1 1385515.N791_14700 1.93e-102 308.0 COG0649@1|root,COG0649@2|Bacteria,1MVIN@1224|Proteobacteria,1RM98@1236|Gammaproteobacteria,1X3JR@135614|Xanthomonadales 135614|Xanthomonadales C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoD - 1.6.5.3 ko:K00333 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_30kDa,Complex1_49kDa k59_1340333_1 436308.Nmar_1382 1.44e-108 315.0 COG1491@1|root,arCOG04130@2157|Archaea,41SGD@651137|Thaumarchaeota 651137|Thaumarchaeota J Protein of unknown function (DUF655) - - - ko:K07572 - - - - ko00000 - - - DUF655 k59_1340333_2 436308.Nmar_1381 7.39e-49 162.0 COG0030@1|root,arCOG04131@2157|Archaea,41SN0@651137|Thaumarchaeota 651137|Thaumarchaeota J Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family - - 2.1.1.182 ko:K02528 - - R10716 RC00003,RC03257 ko00000,ko01000,ko03009 - - - RrnaAD k59_1738008_1 1122137.AQXF01000001_gene3100 1.24e-48 173.0 COG1629@1|root,COG4771@2|Bacteria,1MU9K@1224|Proteobacteria,2TS65@28211|Alphaproteobacteria 28211|Alphaproteobacteria P COG1629 Outer membrane receptor proteins, mostly Fe transport - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_329330_1 626887.J057_17950 6.2e-69 226.0 COG0860@1|root,COG0860@2|Bacteria,1MUQK@1224|Proteobacteria,1RMP1@1236|Gammaproteobacteria,4647N@72275|Alteromonadaceae 1236|Gammaproteobacteria M N-acetylmuramoyl-L-alanine amidase amiC - 3.5.1.28 ko:K01448 ko01503,map01503 M00727 R04112 RC00064,RC00141 ko00000,ko00001,ko00002,ko01000,ko01011,ko03036 - - - AMIN,Amidase_3,LysM k59_1515446_1 258594.RPA3530 6.67e-44 157.0 COG0707@1|root,COG0707@2|Bacteria,1MVIB@1224|Proteobacteria,2TSEY@28211|Alphaproteobacteria,3JT97@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria M Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) murG - 2.4.1.227 ko:K02563 ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112 - R05032,R05662 RC00005,RC00049 ko00000,ko00001,ko01000,ko01011 - GT28 - Glyco_tran_28_C,Glyco_transf_28 k59_1173849_1 396588.Tgr7_3092 3.46e-84 265.0 COG0606@1|root,COG0606@2|Bacteria,1MU4R@1224|Proteobacteria,1RMB9@1236|Gammaproteobacteria,1WWMF@135613|Chromatiales 135613|Chromatiales O PFAM Magnesium chelatase, ChlI subunit - - - ko:K07391 - - - - ko00000 - - - ChlI,Mg_chelatase,Mg_chelatase_C k59_548099_1 1415778.JQMM01000001_gene1239 3.25e-123 368.0 COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,1RMQQ@1236|Gammaproteobacteria,1J523@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H COG0028 Thiamine pyrophosphate-requiring enzymes acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase ilvI GO:0000287,GO:0003674,GO:0003824,GO:0003984,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006549,GO:0006573,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009097,GO:0009099,GO:0009987,GO:0016053,GO:0016740,GO:0016744,GO:0019752,GO:0019842,GO:0030976,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046872,GO:0048037,GO:0050662,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1901681 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - iAPECO1_1312.APECO1_1907,iB21_1397.B21_00078,iBWG_1329.BWG_0073,iECBD_1354.ECBD_3539,iECB_1328.ECB_00079,iECD_1391.ECD_00079,iUTI89_1310.UTI89_C0085,iYL1228.KPN_00082 TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_611029_1 269796.Rru_A1592 7.58e-90 277.0 COG0743@1|root,COG0743@2|Bacteria,1MU4G@1224|Proteobacteria,2TSD1@28211|Alphaproteobacteria,2JQ6Y@204441|Rhodospirillales 204441|Rhodospirillales I Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) dxr - 1.1.1.267 ko:K00099 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05688 RC01452 ko00000,ko00001,ko00002,ko01000 - - - DXPR_C,DXP_redisom_C,DXP_reductoisom k59_385942_1 557598.LHK_02089 1.72e-10 57.8 COG3114@1|root,COG3114@2|Bacteria 2|Bacteria U Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes ccmD GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0009898,GO:0015886,GO:0016020,GO:0031224,GO:0031226,GO:0031235,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051181,GO:0051234,GO:0071702,GO:0071705,GO:0071944,GO:0098552,GO:0098562,GO:1901678 - ko:K02196 ko02010,map02010 - - - ko00000,ko00001,ko02000 3.A.1.107 - iB21_1397.B21_02084,iBWG_1329.BWG_1971,iE2348C_1286.E2348C_2342,iEC042_1314.EC042_2439,iEC55989_1330.EC55989_2451,iECABU_c1320.ECABU_c25320,iECBD_1354.ECBD_1462,iECB_1328.ECB_02125,iECDH10B_1368.ECDH10B_2355,iECDH1ME8569_1439.ECDH1ME8569_2133,iECD_1391.ECD_02125,iECED1_1282.ECED1_2663,iECH74115_1262.ECH74115_3335,iECIAI1_1343.ECIAI1_2280,iECIAI39_1322.ECIAI39_2336,iECNA114_1301.ECNA114_2290,iECO103_1326.ECO103_2673,iECO111_1330.ECO111_2934,iECO26_1355.ECO26_3124,iECOK1_1307.ECOK1_2432,iECP_1309.ECP_2238,iECS88_1305.ECS88_2345,iECSE_1348.ECSE_2466,iECSF_1327.ECSF_2079,iECSP_1301.ECSP_3077,iECUMN_1333.ECUMN_2533,iECs_1301.ECs3087,iEKO11_1354.EKO11_1558,iETEC_1333.ETEC_2332,iEcDH1_1363.EcDH1_1461,iEcE24377_1341.EcE24377A_2497,iEcHS_1320.EcHS_A2336,iEcSMS35_1347.EcSMS35_2346,iEcolC_1368.EcolC_1452,iJO1366.b2198,iLF82_1304.LF82_0276,iNRG857_1313.NRG857_11155,iSDY_1059.SDY_0880,iSFV_1184.SFV_2274,iSF_1195.SF2282,iSSON_1240.SSON_2256,iS_1188.S2412,iUMN146_1321.UM146_05815,iUMNK88_1353.UMNK88_2745,iUTI89_1310.UTI89_C2476,iY75_1357.Y75_RS11500,iZ_1308.Z3455,ic_1306.c2735 CcmD k59_385942_2 1454004.AW11_02928 2.39e-119 345.0 COG0755@1|root,COG0755@2|Bacteria,1MU61@1224|Proteobacteria,2VHF8@28216|Betaproteobacteria,1KQ7H@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria U Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes ccmC - - ko:K02195 ko02010,map02010 M00259 - - ko00000,ko00001,ko00002,ko02000 3.A.1.107 - - Cytochrom_C_asm k59_1738034_1 1550073.JROH01000027_gene959 1.38e-28 118.0 COG1629@1|root,COG4206@1|root,COG1629@2|Bacteria,COG4206@2|Bacteria,1QU0Y@1224|Proteobacteria,2TW37@28211|Alphaproteobacteria,2KE9Q@204457|Sphingomonadales 204457|Sphingomonadales HP TonB dependent receptor - - - - - - - - - - - - Plug,TonB_dep_Rec k59_1625685_1 1379270.AUXF01000004_gene2944 1.46e-85 259.0 COG0388@1|root,COG0388@2|Bacteria,1ZU96@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Carbon-nitrogen hydrolase - - - - - - - - - - - - CN_hydrolase k59_1738036_1 259536.Psyc_0223 1.61e-09 62.8 COG1020@1|root,COG1020@2|Bacteria,1N7HY@1224|Proteobacteria,1RQJX@1236|Gammaproteobacteria,3NIJ1@468|Moraxellaceae 1236|Gammaproteobacteria Q Protein of unknown function (DUF1298) atfA1 - 2.3.1.20 ko:K00635 ko00561,ko01100,map00561,map01100 M00089 R02251 RC00004,RC00041 ko00000,ko00001,ko00002,ko01000 - - - DUF1298,WES_acyltransf k59_1062193_1 1117315.AHCA01000017_gene1581 3.49e-16 81.3 COG4225@1|root,COG4225@2|Bacteria,1NSJK@1224|Proteobacteria,1T1DP@1236|Gammaproteobacteria 1236|Gammaproteobacteria S unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins - - - - - - - - - - - - Glyco_hydro_88 k59_663259_1 215803.DB30_1351 9.29e-50 169.0 COG2159@1|root,COG2159@2|Bacteria 2|Bacteria E amidohydrolase - - - ko:K07045 - - - - ko00000 - - - Amidohydro_2 k59_1229878_1 1056820.KB900638_gene100 1.04e-15 78.2 COG1164@1|root,COG1164@2|Bacteria,1MXAC@1224|Proteobacteria,1RPMX@1236|Gammaproteobacteria,2PPGS@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria E Oligopeptidase F pepF - - ko:K08602 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M3,Peptidase_M3_N k59_1229878_2 1265503.KB905176_gene4095 2.42e-17 85.1 COG4943@1|root,COG4943@2|Bacteria,1MVTH@1224|Proteobacteria,1RMDP@1236|Gammaproteobacteria 1236|Gammaproteobacteria T signal transduction protein containing sensor and EAL yjcC - - - - - - - - - - - CSS-motif,EAL k59_1284072_1 626887.J057_22665 5.64e-57 188.0 COG0583@1|root,COG0583@2|Bacteria,1MU8N@1224|Proteobacteria,1RN7T@1236|Gammaproteobacteria,464YF@72275|Alteromonadaceae 1236|Gammaproteobacteria K Transcriptional regulator cysB GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0009314,GO:0009628,GO:0010165,GO:0010212,GO:0042802,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0097159,GO:1901363 - ko:K13634 - - - - ko00000,ko03000 - - - HTH_1,LysR_substrate k59_1572892_1 1056820.KB900631_gene2318 2.85e-41 143.0 COG4967@1|root,COG4967@2|Bacteria,1N6TG@1224|Proteobacteria,1SC9Z@1236|Gammaproteobacteria,2PP2P@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria NU type IV pilus modification protein PilV pilV - - ko:K02671 - - - - ko00000,ko02035,ko02044 - - - N_methyl k59_1572892_2 1116472.MGMO_6c00210 8.15e-05 45.4 COG4966@1|root,COG4966@2|Bacteria,1R5YK@1224|Proteobacteria,1RZIZ@1236|Gammaproteobacteria,1XF4P@135618|Methylococcales 135618|Methylococcales NU Type IV Pilus-assembly protein W - - - ko:K02672 - - - - ko00000,ko02035,ko02044 - - - N_methyl,PilW k59_1173876_1 1122137.AQXF01000003_gene2431 4.3e-55 183.0 COG1808@1|root,COG1808@2|Bacteria,1NMS3@1224|Proteobacteria,2U6AC@28211|Alphaproteobacteria 28211|Alphaproteobacteria M membrane - - - - - - - - - - - - DUF389 k59_1062206_1 1056820.KB900630_gene1375 1.25e-11 69.7 COG0642@1|root,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,1RWVB@1236|Gammaproteobacteria,2PPB1@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria T HAMP domain - - - - - - - - - - - - HAMP,HATPase_c,HisKA k59_611072_2 1229909.NSED_02590 1.45e-23 91.3 COG1872@1|root,arCOG04058@2157|Archaea,41TAX@651137|Thaumarchaeota 651137|Thaumarchaeota S DUF167 - - - ko:K09131 - - - - ko00000 - - - DUF167 k59_611072_3 1229909.NSED_02595 1.17e-168 473.0 COG0396@1|root,arCOG04236@2157|Archaea,41SE1@651137|Thaumarchaeota 651137|Thaumarchaeota O FeS assembly ATPase SufC - - - ko:K09013 - - - - ko00000,ko02000 - - - ABC_tran k59_1515475_2 1121033.AUCF01000026_gene2977 1.33e-139 400.0 COG3384@1|root,COG3384@2|Bacteria,1MW77@1224|Proteobacteria,2TRP1@28211|Alphaproteobacteria,2JWA9@204441|Rhodospirillales 204441|Rhodospirillales S Catalytic LigB subunit of aromatic ring-opening dioxygenase - - 1.13.11.8 ko:K04101 ko00362,ko00624,ko00627,ko01120,map00362,map00624,map00627,map01120 - R01632,R03550,R04280,R09565 RC00233,RC00387,RC00535,RC02567,RC02694 br01602,ko00000,ko00001,ko01000 - - - LigB k59_1790529_1 317013.NY99_05785 6.02e-45 150.0 COG2905@1|root,COG2905@2|Bacteria,1QTTR@1224|Proteobacteria,1T1K1@1236|Gammaproteobacteria,1X6ZX@135614|Xanthomonadales 135614|Xanthomonadales T CBS domain - - - - - - - - - - - - CBS k59_1173896_1 1121456.ATVA01000019_gene1239 3.36e-07 58.5 COG2982@1|root,COG2982@2|Bacteria,1NVUY@1224|Proteobacteria,42P4T@68525|delta/epsilon subdivisions,2WKBS@28221|Deltaproteobacteria,2M8DW@213115|Desulfovibrionales 28221|Deltaproteobacteria M AsmA family - - - ko:K07289 - - - - ko00000 - - - AsmA,AsmA_2 k59_1515479_1 715226.ABI_44260 1.43e-92 295.0 COG4774@1|root,COG4774@2|Bacteria,1NMCN@1224|Proteobacteria,2U44P@28211|Alphaproteobacteria,2KKA0@204458|Caulobacterales 204458|Caulobacterales P TonB dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_1284113_1 314230.DSM3645_06504 3.78e-50 167.0 COG1089@1|root,COG1089@2|Bacteria,2IWZ4@203682|Planctomycetes 203682|Planctomycetes M Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose gmd - 4.2.1.47 ko:K01711 ko00051,ko00520,ko01100,map00051,map00520,map01100 - R00888 RC00402 ko00000,ko00001,ko01000 - - - GDP_Man_Dehyd k59_1284113_2 357808.RoseRS_3581 1.64e-10 62.0 COG0451@1|root,COG0451@2|Bacteria,2G6S4@200795|Chloroflexi,374RT@32061|Chloroflexia 32061|Chloroflexia M short-chain dehydrogenase reductase SDR - - 5.1.3.6 ko:K08679 ko00520,ko01100,map00520,map01100 - R01385 RC00289 ko00000,ko00001,ko01000 - - - GDP_Man_Dehyd k59_1680931_1 1122137.AQXF01000001_gene2771 2.92e-54 184.0 COG1187@1|root,COG1187@2|Bacteria,1MUCE@1224|Proteobacteria,2TQP2@28211|Alphaproteobacteria 28211|Alphaproteobacteria J Belongs to the pseudouridine synthase RsuA family rluB - 5.4.99.22 ko:K06178 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2,S4 k59_1680931_2 1122182.KB903833_gene5358 2.61e-30 115.0 COG0742@1|root,COG0742@2|Bacteria,2GQ3G@201174|Actinobacteria,4D8ZN@85008|Micromonosporales 201174|Actinobacteria L Methyltransferase rsmD - 2.1.1.171 ko:K08316 - - R07234 RC00003 ko00000,ko01000,ko03009 - - - Cons_hypoth95 k59_213404_1 926569.ANT_31260 4.27e-55 186.0 COG1109@1|root,COG1109@2|Bacteria,2G5PR@200795|Chloroflexi 200795|Chloroflexi G Phosphoglucomutase/phosphomannomutase, C-terminal domain - - - - - - - - - - - - PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV k59_548143_1 199310.c5026 3.44e-152 438.0 COG0305@1|root,COG0305@2|Bacteria,1MUG9@1224|Proteobacteria,1RPM2@1236|Gammaproteobacteria,3XNZC@561|Escherichia 1236|Gammaproteobacteria L it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins dnaB GO:0003674,GO:0003678,GO:0003824,GO:0004386,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006268,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009628,GO:0009987,GO:0010212,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0032392,GO:0032508,GO:0034641,GO:0034645,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051276,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360,GO:1901576 3.6.4.12 ko:K02314 ko03030,ko04112,map03030,map04112 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB,DnaB_C k59_1412196_1 1479239.JQMU01000001_gene311 4.53e-14 70.9 COG3178@1|root,COG3178@2|Bacteria,1MXCH@1224|Proteobacteria,2TSJD@28211|Alphaproteobacteria,2K04R@204457|Sphingomonadales 204457|Sphingomonadales S Phosphotransferase - - 2.7.1.221 ko:K07102 ko00520,ko01100,map00520,map01100 - R08968,R11024 RC00002,RC00078 ko00000,ko00001,ko01000 - - - APH k59_1412196_2 1088721.NSU_3982 5.46e-78 235.0 COG0802@1|root,COG0802@2|Bacteria,1RGYU@1224|Proteobacteria,2UBQ9@28211|Alphaproteobacteria,2K5A7@204457|Sphingomonadales 204457|Sphingomonadales S ATPase or kinase - - - ko:K06925 - - - - ko00000,ko03016 - - - TsaE k59_1238525_1 187272.Mlg_0930 8.14e-44 149.0 COG0283@1|root,COG0283@2|Bacteria,1MUUD@1224|Proteobacteria,1RNKT@1236|Gammaproteobacteria,1WXNU@135613|Chromatiales 135613|Chromatiales F Belongs to the cytidylate kinase family. Type 1 subfamily cmk - 2.7.4.25 ko:K00945 ko00240,ko01100,map00240,map01100 M00052 R00158,R00512,R01665 RC00002 ko00000,ko00001,ko00002,ko01000 - - - Cytidylate_kin k59_1524461_1 1049564.TevJSym_al00210 6.48e-281 803.0 COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1146@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1146@2|Bacteria,1MVM0@1224|Proteobacteria,1RNNX@1236|Gammaproteobacteria,1J7JF@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin nifJ - 1.2.7.1 ko:K03737 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00173,M00307 R01196,R10866 RC00004,RC02742 br01601,ko00000,ko00001,ko00002,ko01000 - - - EKR,Fer4,Fer4_16,Fer4_7,PFOR_II,POR,POR_N,TPP_enzyme_C k59_1123996_1 1038867.AXAY01000055_gene4151 2.52e-08 60.8 COG0457@1|root,COG3710@1|root,COG5616@1|root,COG0457@2|Bacteria,COG3710@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2TRUI@28211|Alphaproteobacteria,3JR8W@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria T Adenylate cyclase - - - - - - - - - - - - Guanylate_cyc,TPR_16,TPR_2,TPR_8,Trans_reg_C k59_501233_1 706587.Desti_4981 1.02e-75 253.0 COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,42M9W@68525|delta/epsilon subdivisions,2WJ29@28221|Deltaproteobacteria,2MREW@213462|Syntrophobacterales 28221|Deltaproteobacteria O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner lon-3 - 3.4.21.53 ko:K01338 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - AAA,LON_substr_bdg,Lon_C k59_501234_1 485916.Dtox_3758 1.75e-42 156.0 COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,1TQ0B@1239|Firmicutes,248IB@186801|Clostridia,260N1@186807|Peptococcaceae 186801|Clostridia E glutamate synthase gltB - 1.4.1.13,1.4.1.14,1.4.7.1 ko:K00265,ko:K00284 ko00250,ko00630,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00630,map00910,map01100,map01110,map01120,map01130,map01230 - R00021,R00093,R00114,R00248,R10086 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - GATase_2,GXGXG,Glu_syn_central,Glu_synthase k59_1124005_1 187272.Mlg_1537 3.29e-13 64.3 COG4877@1|root,COG4877@2|Bacteria,1NNE2@1224|Proteobacteria,1SGNK@1236|Gammaproteobacteria,1WZNZ@135613|Chromatiales 135613|Chromatiales S Ribbon-helix-helix protein, copG family - - - - - - - - - - - - RHH_1,RHH_5 k59_1124005_3 314345.SPV1_08761 1.23e-12 66.6 2E80T@1|root,332F0@2|Bacteria,1N7RY@1224|Proteobacteria 1224|Proteobacteria S Domain of unknown function (DUF4389) - - - - - - - - - - - - DUF4389 k59_557138_1 497321.C664_13799 7.16e-16 80.5 COG1910@1|root,COG2005@1|root,COG1910@2|Bacteria,COG2005@2|Bacteria,1MVS4@1224|Proteobacteria,2VH5J@28216|Betaproteobacteria,2KW5M@206389|Rhodocyclales 206389|Rhodocyclales P Transcriptional regulator of molybdate metabolism, LysR family protein - - - - - - - - - - - - HTH_1,PBP_like k59_1524480_1 1322246.BN4_12019 1.52e-18 84.3 COG0589@1|root,COG0589@2|Bacteria,1PDTQ@1224|Proteobacteria,42T4W@68525|delta/epsilon subdivisions,2WP70@28221|Deltaproteobacteria,2MCM7@213115|Desulfovibrionales 28221|Deltaproteobacteria T Belongs to the universal stress protein A family - - - - - - - - - - - - Usp k59_222381_1 1415778.JQMM01000001_gene1288 1.16e-57 186.0 COG2126@1|root,COG2126@2|Bacteria,1MXCS@1224|Proteobacteria,1RPCN@1236|Gammaproteobacteria,1J4KD@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J COG1226 Kef-type K transport systems kch - - ko:K10716 - - - - ko00000,ko02000 1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6 - - Ion_trans k59_222381_2 504472.Slin_3431 1.18e-14 67.0 2E3AG@1|root,32Y9Z@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_395257_1 1122137.AQXF01000001_gene3188 5.11e-167 471.0 COG0180@1|root,COG0180@2|Bacteria,1MV4T@1224|Proteobacteria,2TQZX@28211|Alphaproteobacteria 28211|Alphaproteobacteria J Tryptophanyl-tRNA synthetase trpS - 6.1.1.2 ko:K01867 ko00970,map00970 M00359,M00360 R03664 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_1b k59_1009677_1 195250.CM001776_gene1580 9.76e-19 91.7 COG1649@1|root,COG1649@2|Bacteria,1G2UW@1117|Cyanobacteria,1H3X3@1129|Synechococcus 1117|Cyanobacteria S Putative glycosyl hydrolase domain - - - - - - - - - - - - GHL10 k59_1349319_1 1150626.PHAMO_230005 4.37e-128 387.0 COG0296@1|root,COG0296@2|Bacteria,1QTVN@1224|Proteobacteria,2TR5K@28211|Alphaproteobacteria,2JPD9@204441|Rhodospirillales 204441|Rhodospirillales G Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position glgB - 2.4.1.18 ko:K00700 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R02110 - ko00000,ko00001,ko00002,ko01000,ko04147 - CBM48,GH13 - Alpha-amylase,Alpha-amylase_C,CBM_48 k59_843345_1 933262.AXAM01000009_gene1480 2.76e-16 77.0 COG0398@1|root,COG0398@2|Bacteria,1QKZU@1224|Proteobacteria,42SRQ@68525|delta/epsilon subdivisions,2WP35@28221|Deltaproteobacteria 28221|Deltaproteobacteria S PFAM SNARE associated Golgi protein - - - - - - - - - - - - SNARE_assoc k59_395267_1 1267533.KB906733_gene2985 2.68e-21 97.8 COG0577@1|root,COG0577@2|Bacteria 2|Bacteria V efflux transmembrane transporter activity - - - - - - - - - - - - FtsX,MacB_PCD k59_1524484_2 1120963.KB894506_gene3843 1e-33 129.0 COG0714@1|root,COG0714@2|Bacteria,1MUFN@1224|Proteobacteria,1RN5G@1236|Gammaproteobacteria,2Q48M@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria S ATPase family associated with various cellular activities (AAA) - - - ko:K03924 - - - - ko00000,ko01000 - - - AAA_3 k59_54982_1 713586.KB900536_gene2577 4.34e-47 175.0 COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,1RNQN@1236|Gammaproteobacteria,1WX6D@135613|Chromatiales 135613|Chromatiales KLT Protein tyrosine kinase - - - - - - - - - - - - Pkinase k59_1690081_1 1565129.JSFF01000006_gene2557 3.64e-123 367.0 COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,1RMQ4@1236|Gammaproteobacteria,2QAZB@267890|Shewanellaceae 1236|Gammaproteobacteria IQ PFAM AMP-dependent synthetase and ligase caiC GO:0003674,GO:0003824,GO:0016405,GO:0016874,GO:0016877,GO:0016879,GO:0016881,GO:0051108,GO:0051109 6.2.1.48 ko:K02182 - - - - ko00000,ko01000 - - iECSE_1348.ECSE_0038,iNRG857_1313.NRG857_00195 AMP-binding,AMP-binding_C k59_501254_1 1197477.IA57_08100 3.55e-84 273.0 COG0403@1|root,COG1003@1|root,COG0403@2|Bacteria,COG1003@2|Bacteria,4NEDE@976|Bacteroidetes,1HXCU@117743|Flavobacteriia 976|Bacteroidetes E The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor gcvP - 1.4.4.2 ko:K00281,ko:K00283 ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200 M00532 R01221,R03425 RC00022,RC00929,RC02834,RC02880 ko00000,ko00001,ko00002,ko01000 - - - Aminotran_5,GDC-P k59_903526_1 1122225.AULQ01000001_gene1642 1.28e-74 244.0 COG1674@1|root,COG1674@2|Bacteria,4NE86@976|Bacteroidetes,1HXBM@117743|Flavobacteriia 976|Bacteroidetes D cell division protein FtsK ftsK - - ko:K03466 - - - - ko00000,ko03036 3.A.12 - - FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma k59_903526_2 1469557.JSWF01000024_gene1822 1.88e-07 51.6 COG2834@1|root,COG2834@2|Bacteria,4NFGN@976|Bacteroidetes,1HX3V@117743|Flavobacteriia 976|Bacteroidetes M outer membrane lipoprotein carrier protein LolA lolA - - ko:K03634 - - - - ko00000 - - - LolA,LolA_2 k59_1009714_1 1121937.AUHJ01000001_gene349 7.48e-81 249.0 COG2515@1|root,COG2515@2|Bacteria,1MVYF@1224|Proteobacteria,1RMYP@1236|Gammaproteobacteria,4670H@72275|Alteromonadaceae 1236|Gammaproteobacteria E Pyridoxal-phosphate dependent enzyme - - 4.4.1.15 ko:K05396 ko00270,map00270 - R01874 RC00382 ko00000,ko00001,ko01000 - - - PALP k59_1350446_2 1131269.AQVV01000001_gene1378 1.08e-23 100.0 COG2834@1|root,COG2834@2|Bacteria 2|Bacteria M Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) lolA - - ko:K03634 - - - - ko00000 - - - LolA k59_1748117_1 1088721.NSU_2476 2.48e-138 400.0 COG4553@1|root,COG4553@2|Bacteria,1MVUH@1224|Proteobacteria,2TQXW@28211|Alphaproteobacteria,2K1W9@204457|Sphingomonadales 204457|Sphingomonadales I de-polymerase phaZ - 3.1.1.75 ko:K05973 ko00650,map00650 - R05118 - ko00000,ko00001,ko01000 - - - PHB_depo_C k59_1294554_1 1123400.KB904748_gene333 5.83e-73 228.0 COG4302@1|root,COG4302@2|Bacteria,1MWQI@1224|Proteobacteria,1RQ2T@1236|Gammaproteobacteria 1236|Gammaproteobacteria E Belongs to the EutC family eutC - 4.3.1.7 ko:K03736 ko00564,ko01100,map00564,map01100 - R00749 RC00370 ko00000,ko00001,ko01000 - - - EutC k59_1294560_1 436308.Nmar_1744 5.43e-60 189.0 arCOG08767@1|root,arCOG08767@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_844482_1 314278.NB231_08032 5.15e-40 135.0 COG0199@1|root,COG0199@2|Bacteria,1MZDT@1224|Proteobacteria,1S62N@1236|Gammaproteobacteria,1WYNJ@135613|Chromatiales 135613|Chromatiales J Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site rpsN - - ko:K02954 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S14 k59_844482_2 1382306.JNIM01000001_gene3535 3.15e-18 79.7 COG0096@1|root,COG0096@2|Bacteria,2G6XS@200795|Chloroflexi 200795|Chloroflexi J One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit rpsH GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - ko:K02994 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S8 k59_223629_1 1123401.JHYQ01000027_gene3101 1.94e-33 134.0 COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,1RPCB@1236|Gammaproteobacteria,4605Q@72273|Thiotrichales 72273|Thiotrichales O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner lon - 3.4.21.53 ko:K01338 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - AAA,LON_substr_bdg,Lon_C k59_1464295_1 1042375.AFPL01000022_gene2583 3.18e-113 359.0 COG5373@1|root,COG5373@2|Bacteria,1N08V@1224|Proteobacteria,1RTF0@1236|Gammaproteobacteria,46626@72275|Alteromonadaceae 1236|Gammaproteobacteria S Predicted membrane protein (DUF2339) - - - - - - - - - - - - DUF2339 k59_784960_1 1122137.AQXF01000002_gene538 3e-144 408.0 COG0047@1|root,COG0047@2|Bacteria,1MU4Y@1224|Proteobacteria,2TS67@28211|Alphaproteobacteria 28211|Alphaproteobacteria F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL purQ GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 6.3.5.3 ko:K01952 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04463 RC00010,RC01160 ko00000,ko00001,ko00002,ko01000 - - - GATase_5 k59_1691125_1 227086.JGI_V11_55750 3.06e-21 95.5 COG2267@1|root,KOG1455@2759|Eukaryota 2759|Eukaryota I acylglycerol lipase activity - - 3.1.1.23 ko:K01054 ko00561,ko01100,ko04714,ko04723,ko04923,map00561,map01100,map04714,map04723,map04923 M00098 R01351 RC00020,RC00041 ko00000,ko00001,ko00002,ko01000,ko01002 - - - Hydrolase_4 k59_1691127_1 1313172.YM304_21580 5.08e-99 317.0 COG0178@1|root,COG0178@2|Bacteria,2GJUV@201174|Actinobacteria,4CMUS@84992|Acidimicrobiia 84992|Acidimicrobiia L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate uvrA - - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - ABC_tran k59_502425_1 1415778.JQMM01000001_gene2129 2.68e-55 198.0 COG2202@1|root,COG4191@1|root,COG2202@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,1RP53@1236|Gammaproteobacteria,1J53Q@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T Histidine kinase - - - - - - - - - - - - HAMP,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg k59_166501_1 1123239.KB898624_gene1930 1.56e-24 104.0 COG0657@1|root,COG0657@2|Bacteria,1TQHX@1239|Firmicutes,4HB91@91061|Bacilli 91061|Bacilli I Esterase - - - ko:K01066 - - - - ko00000,ko01000 - - - Abhydrolase_3 k59_502433_1 1331060.RLDS_17990 1.16e-154 443.0 COG2159@1|root,COG2159@2|Bacteria,1R4UN@1224|Proteobacteria,2U2QQ@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Amidohydrolase - - - - - - - - - - - - Amidohydro_2 k59_1010932_1 28229.ND2E_3990 1.57e-67 225.0 COG1228@1|root,COG1228@2|Bacteria,1PDWI@1224|Proteobacteria,1RXW9@1236|Gammaproteobacteria,2Q8CA@267889|Colwelliaceae 1236|Gammaproteobacteria Q Amidohydrolase family - - - - - - - - - - - - Amidohydro_1 k59_1072459_1 1117647.M5M_08865 4.85e-13 73.2 COG1215@1|root,COG1215@2|Bacteria,1QUFX@1224|Proteobacteria,1RN4M@1236|Gammaproteobacteria,1J59C@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M COG1215 Glycosyltransferases, probably involved in cell wall biogenesis gt2M - - - - - - - - - - - Glyco_tranf_2_3,Glycos_transf_2 k59_1125249_1 2340.JV46_07510 5.7e-44 165.0 COG1033@1|root,COG1033@2|Bacteria,1MUE1@1224|Proteobacteria,1RPIP@1236|Gammaproteobacteria,1J96Q@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M MMPL family VP1286 - - ko:K07003 - - - - ko00000 - - - MMPL k59_281768_1 1122137.AQXF01000001_gene2745 6.97e-109 327.0 COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,2TR2Z@28211|Alphaproteobacteria 28211|Alphaproteobacteria C COG0277 FAD FMN-containing dehydrogenases dld GO:0003674,GO:0003824,GO:0004457,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008720,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016491,GO:0016614,GO:0016616,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019866,GO:0031090,GO:0031966,GO:0031967,GO:0031975,GO:0034641,GO:0034654,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046034,GO:0046390,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 1.1.1.303,1.1.1.4,1.1.2.4 ko:K00004,ko:K00102 ko00620,ko00650,map00620,map00650 - R00197,R02855,R02946,R10504 RC00044,RC00205,RC00525 ko00000,ko00001,ko01000 - - - FAD-oxidase_C,FAD_binding_4 k59_1691155_1 1121935.AQXX01000141_gene2101 4.43e-39 142.0 COG1409@1|root,COG1409@2|Bacteria,1MWKX@1224|Proteobacteria,1RPA7@1236|Gammaproteobacteria,1XJ9U@135619|Oceanospirillales 135619|Oceanospirillales S Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes cpdA - 3.1.4.53 ko:K03651 ko00230,ko02025,map00230,map02025 - R00191 RC00296 ko00000,ko00001,ko01000 - - - Metallophos k59_673451_1 549.BW31_01901 4.94e-84 273.0 COG2352@1|root,COG2352@2|Bacteria,1MUD5@1224|Proteobacteria,1RPTP@1236|Gammaproteobacteria,3VYUC@53335|Pantoea 1236|Gammaproteobacteria H Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle ppc GO:0003674,GO:0003824,GO:0004611,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0008964,GO:0009060,GO:0009987,GO:0015980,GO:0016829,GO:0016830,GO:0016831,GO:0016999,GO:0017144,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0055114,GO:0071704,GO:0072350 4.1.1.31 ko:K01595 ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200 M00168,M00170,M00171,M00172,M00173,M00346,M00374 R00345 RC02741 ko00000,ko00001,ko00002,ko01000 - - iSFV_1184.SFV_4025 PEPcase k59_1072478_1 1121035.AUCH01000014_gene2371 3.33e-48 165.0 COG1270@1|root,COG1270@2|Bacteria,1MWCK@1224|Proteobacteria,2VH7X@28216|Betaproteobacteria,2KUFS@206389|Rhodocyclales 206389|Rhodocyclales H Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group - - 6.3.1.10 ko:K02227 ko00860,ko01100,map00860,map01100 M00122 R06529,R07302 RC00090,RC00096 ko00000,ko00001,ko00002,ko01000 - - - CobD_Cbib k59_1748173_1 1000565.METUNv1_03487 7.68e-111 334.0 COG0804@1|root,COG0804@2|Bacteria,1MU5P@1224|Proteobacteria,2VJYX@28216|Betaproteobacteria,2KUE8@206389|Rhodocyclales 206389|Rhodocyclales E Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family ureC - 3.5.1.5 ko:K01428 ko00220,ko00230,ko00791,ko01100,ko01120,ko05120,map00220,map00230,map00791,map01100,map01120,map05120 - R00131 RC02798,RC02806 ko00000,ko00001,ko01000 - - - Amidohydro_1,Urease_alpha k59_447327_2 1229909.NSED_09600 1.41e-126 370.0 COG0112@1|root,arCOG00070@2157|Archaea,41S7U@651137|Thaumarchaeota 651137|Thaumarchaeota E Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism glyA - 2.1.2.1 ko:K00600 ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523 M00140,M00141,M00346,M00532 R00945,R09099 RC00022,RC00112,RC01583,RC02958 ko00000,ko00001,ko00002,ko01000 - - - SHMT k59_166535_1 158500.BV97_03609 7.89e-92 277.0 COG2030@1|root,COG2030@2|Bacteria,1NAYM@1224|Proteobacteria,2TRU0@28211|Alphaproteobacteria,2K3I1@204457|Sphingomonadales 204457|Sphingomonadales I MaoC like domain - - - - - - - - - - - - MaoC_dehydrat_N k59_166535_2 13690.CP98_04264 3.69e-89 273.0 COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2TR7Q@28211|Alphaproteobacteria,2K8HG@204457|Sphingomonadales 204457|Sphingomonadales C CoA-transferase family III - - - - - - - - - - - - CoA_transf_3 k59_1010986_1 713586.KB900536_gene2809 2.68e-46 155.0 COG2085@1|root,COG2085@2|Bacteria,1RCXR@1224|Proteobacteria,1S463@1236|Gammaproteobacteria 1236|Gammaproteobacteria S NADP oxidoreductase, coenzyme f420-dependent - - 1.5.1.40 ko:K06988 - - - - ko00000,ko01000 - - - F420_oxidored k59_1010986_2 1121020.JIAG01000002_gene885 3.88e-05 46.6 COG0204@1|root,COG0204@2|Bacteria,2GP8A@201174|Actinobacteria 201174|Actinobacteria I Acyltransferase - - 2.3.1.51 ko:K00655 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R02241,R09381 RC00004,RC00037,RC00039 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Acyltransferase k59_447339_1 187272.Mlg_2127 1.13e-73 240.0 COG1022@1|root,COG1022@2|Bacteria,1MU4D@1224|Proteobacteria,1RPNE@1236|Gammaproteobacteria,1WVYG@135613|Chromatiales 135613|Chromatiales I PFAM AMP-dependent synthetase - - 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding k59_502475_1 1282361.ABAC402_06770 8.79e-13 69.7 COG4225@1|root,COG4225@2|Bacteria,1MU2J@1224|Proteobacteria,2TUBE@28211|Alphaproteobacteria,2KHK2@204458|Caulobacterales 204458|Caulobacterales S Glycosyl Hydrolase Family 88 - - 3.2.1.172 ko:K15532 - - - - ko00000,ko01000 - GH105 - Glyco_hydro_88 k59_502475_2 56780.SYN_00950 2.44e-38 138.0 COG2877@1|root,COG2877@2|Bacteria,1MV91@1224|Proteobacteria,42M61@68525|delta/epsilon subdivisions,2WIXU@28221|Deltaproteobacteria,2MQA2@213462|Syntrophobacterales 28221|Deltaproteobacteria M PFAM DAHP synthetase I kdsA - 2.5.1.55 ko:K01627 ko00540,ko01100,map00540,map01100 M00063 R03254 RC00435 ko00000,ko00001,ko00002,ko01000,ko01005 - - - DAHP_synth_1 k59_1183972_1 404589.Anae109_2758 6.67e-69 222.0 COG3256@1|root,COG3256@2|Bacteria,1MVT1@1224|Proteobacteria,42NBM@68525|delta/epsilon subdivisions,2WKTG@28221|Deltaproteobacteria 28221|Deltaproteobacteria P PFAM Cytochrome c oxidase, subunit I - - 1.7.2.5 ko:K04561 ko00910,ko01120,map00910,map01120 M00529 R00294 RC02794 ko00000,ko00001,ko00002,ko01000 3.D.4.10 - - COX1 k59_955516_1 243231.GSU1176 3.49e-46 157.0 2CAZH@1|root,2Z7RU@2|Bacteria,1RBDC@1224|Proteobacteria,42SC7@68525|delta/epsilon subdivisions,2WP8S@28221|Deltaproteobacteria,43SJW@69541|Desulfuromonadales 28221|Deltaproteobacteria C TIGRFAM succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family frdC - - ko:K00241 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00149,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002 - - - Sdh_cyt k59_955516_2 398767.Glov_2213 4.52e-17 79.3 COG1053@1|root,COG1053@2|Bacteria,1MU5M@1224|Proteobacteria,42M81@68525|delta/epsilon subdivisions,2WIJ5@28221|Deltaproteobacteria 28221|Deltaproteobacteria C TIGRFAM succinate dehydrogenase or fumarate reductase, flavoprotein subunit frdA - 1.3.5.1,1.3.5.4 ko:K00239 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134 M00009,M00011,M00149,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,Succ_DH_flav_C k59_673477_1 1229909.NSED_03170 1.84e-29 121.0 arCOG08231@1|root,arCOG08231@2157|Archaea,41T6Q@651137|Thaumarchaeota 651137|Thaumarchaeota L Lamin Tail Domain - - - - - - - - - - - - LTD k59_1800626_1 436308.Nmar_0481 1.08e-177 500.0 COG0573@1|root,arCOG00167@2157|Archaea,41SYE@651137|Thaumarchaeota 651137|Thaumarchaeota P probably responsible for the translocation of the substrate across the membrane - - - ko:K02037 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - BPD_transp_1 k59_785037_1 1282876.BAOK01000001_gene1823 5.51e-70 220.0 COG0412@1|root,COG0412@2|Bacteria,1NRB4@1224|Proteobacteria,2TU91@28211|Alphaproteobacteria 28211|Alphaproteobacteria Q dienelactone hydrolase - - 3.1.1.45 ko:K01061 ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130 - R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222 RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686 ko00000,ko00001,ko01000 - - - DLH k59_112232_1 1122137.AQXF01000003_gene2485 3.8e-99 298.0 COG0677@1|root,COG0677@2|Bacteria,1MUC6@1224|Proteobacteria,2TR5F@28211|Alphaproteobacteria 28211|Alphaproteobacteria M Belongs to the UDP-glucose GDP-mannose dehydrogenase family wecC - 1.1.1.336 ko:K02472 ko00520,ko05111,map00520,map05111 - R03317 RC00291 ko00000,ko00001,ko01000 - - - UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N k59_1691206_1 1123487.KB892841_gene4325 9.36e-33 119.0 COG0854@1|root,COG0854@2|Bacteria,1MU9W@1224|Proteobacteria,2VHY7@28216|Betaproteobacteria,2KV09@206389|Rhodocyclales 206389|Rhodocyclales H Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate pdxJ - 2.6.99.2 ko:K03474 ko00750,ko01100,map00750,map01100 M00124 R05838 RC01476 ko00000,ko00001,ko00002,ko01000 - - - PdxJ k59_1691206_2 1348657.M622_02285 1.93e-25 103.0 COG1381@1|root,COG1381@2|Bacteria,1RHIC@1224|Proteobacteria,2VJUC@28216|Betaproteobacteria,2KW9J@206389|Rhodocyclales 206389|Rhodocyclales L Involved in DNA repair and RecF pathway recombination recO - - ko:K03584 ko03440,map03440 - - - ko00000,ko00001,ko03400 - - - RecO_C,RecO_N k59_1800644_1 1131266.ARWQ01000005_gene848 1.07e-11 62.8 arCOG08683@1|root,arCOG08683@2157|Archaea,41SUM@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1800644_2 436308.Nmar_0540 1.44e-62 195.0 COG0454@1|root,arCOG00826@2157|Archaea,41T2E@651137|Thaumarchaeota 651137|Thaumarchaeota K Acetyltransferase (GNAT) domain - - 2.3.1.4 ko:K00621 ko00520,map00520 - R02058 RC00004,RC00166 ko00000,ko00001,ko01000 - - - Acetyltransf_1 k59_166577_1 685035.ADAE01000012_gene129 3.41e-25 99.8 COG3791@1|root,COG3791@2|Bacteria,1NC41@1224|Proteobacteria,2UGK2@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Glutathione-dependent formaldehyde-activating - - - - - - - - - - - - - k59_166577_2 936136.ARRT01000006_gene3290 1.48e-11 64.7 COG0161@1|root,COG0161@2|Bacteria,1MU2N@1224|Proteobacteria,2TQND@28211|Alphaproteobacteria,4B8IZ@82115|Rhizobiaceae 28211|Alphaproteobacteria E Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family - - 2.6.1.96 ko:K16871 ko00250,ko00650,ko01100,ko01120,map00250,map00650,map01100,map01120 M00027 R10178 RC00008,RC00062 ko00000,ko00001,ko00002,ko01000 - - - Aminotran_3 k59_447379_1 710686.Mycsm_03540 6.81e-12 70.9 COG1028@1|root,COG2343@1|root,COG1028@2|Bacteria,COG2343@2|Bacteria,2IKUM@201174|Actinobacteria,23444@1762|Mycobacteriaceae 201174|Actinobacteria IQ Domain of unknown function (DUF427) - - - - - - - - - - - - NTP_transf_9 k59_1464382_1 663932.KB902575_gene2723 2.09e-23 91.7 2EQ1Y@1|root,33HNC@2|Bacteria,1NJMF@1224|Proteobacteria,2UN8S@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_1464382_2 991905.SL003B_0494 3.56e-55 179.0 COG3293@1|root,COG3293@2|Bacteria,1PVIT@1224|Proteobacteria,2TURP@28211|Alphaproteobacteria,4BRIA@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria L COG3293 Transposase and inactivated derivatives - - - - - - - - - - - - DDE_Tnp_1,DDE_Tnp_1_2,DUF4096 k59_1184003_1 1112212.JH584235_gene1037 3.24e-10 66.2 COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,2TT4D@28211|Alphaproteobacteria,2K0BG@204457|Sphingomonadales 204457|Sphingomonadales M RND efflux system, outer membrane lipoprotein - - - - - - - - - - - - OEP k59_1800655_1 1122137.AQXF01000002_gene26 1.86e-139 403.0 COG0489@1|root,COG0489@2|Bacteria,1PDUC@1224|Proteobacteria,2U2MQ@28211|Alphaproteobacteria 28211|Alphaproteobacteria D Involved in chromosome partitioning - - 2.7.10.1 ko:K08252 - - - - ko00000,ko01000 - - - AAA_31,CbiA,ParA k59_1294713_1 460265.Mnod_4678 3.04e-17 85.9 COG2303@1|root,COG2303@2|Bacteria,1MU3F@1224|Proteobacteria,2TT3C@28211|Alphaproteobacteria,1JS86@119045|Methylobacteriaceae 28211|Alphaproteobacteria E PFAM glucose-methanol-choline oxidoreductase MA20_17575 - - - - - - - - - - - GMC_oxred_C,GMC_oxred_N,NAD_binding_8 k59_112270_1 1173028.ANKO01000112_gene4816 1.7e-11 68.2 COG0235@1|root,COG0235@2|Bacteria,1G10W@1117|Cyanobacteria,1H8SZ@1150|Oscillatoriales 1117|Cyanobacteria G PFAM Class II Aldolase and Adducin N-terminal domain - - - - - - - - - - - - Aldolase_II k59_844678_1 1122137.AQXF01000001_gene2601 9.12e-78 251.0 COG1680@1|root,COG1680@2|Bacteria,1PQ2Z@1224|Proteobacteria,2U2RD@28211|Alphaproteobacteria 28211|Alphaproteobacteria V Beta-lactamase - - - - - - - - - - - - Beta-lactamase k59_1294722_1 1122221.JHVI01000005_gene536 4.24e-65 213.0 COG4948@1|root,COG4948@2|Bacteria,1WJ5W@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus M Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB) menC - 4.2.1.113 ko:K02549 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116 R04031 RC01053 ko00000,ko00001,ko00002,ko01000 - - - MR_MLE_C,MR_MLE_N k59_1350617_1 316407.85675731 5.14e-144 417.0 COG0427@1|root,COG0427@2|Bacteria,1MUGE@1224|Proteobacteria,1RP19@1236|Gammaproteobacteria,3XMWJ@561|Escherichia 1236|Gammaproteobacteria C Catalyzes the transfer of coenzyme A from propionyl-CoA to succinate. Could be part of a pathway that converts succinate to propionate scpC GO:0003674,GO:0003824,GO:0003986,GO:0006082,GO:0006083,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0008410,GO:0008775,GO:0009987,GO:0016289,GO:0016740,GO:0016782,GO:0016787,GO:0016788,GO:0016790,GO:0016999,GO:0017144,GO:0019541,GO:0019679,GO:0019752,GO:0032787,GO:0043436,GO:0043821,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0046459,GO:0071704 2.8.3.18 ko:K18118,ko:K22214 ko00020,ko00620,ko00640,ko00650,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00640,map00650,map01100,map01110,map01120,map01130,map01200 M00009,M00011 R10343,R11773 RC00012,RC00014 ko00000,ko00001,ko00002,ko01000 - - iECIAI1_1343.ECIAI1_3040,iECSE_1348.ECSE_3182,iECW_1372.ECW_m3175,iEKO11_1354.EKO11_0812,iWFL_1372.ECW_m3175 AcetylCoA_hyd_C,AcetylCoA_hydro k59_228783_1 936455.KI421499_gene213 2.36e-40 150.0 COG2079@1|root,COG2079@2|Bacteria,1R5CE@1224|Proteobacteria,2TUP7@28211|Alphaproteobacteria,3JW76@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S MmgE/PrpD family - - - - - - - - - - - - MmgE_PrpD k59_851324_1 262316.MAP_3506c 1.37e-45 165.0 COG3386@1|root,COG3386@2|Bacteria,2GNM1@201174|Actinobacteria,233K1@1762|Mycobacteriaceae 201174|Actinobacteria G SMP-30 Gluconolaconase - - - - - - - - - - - - SGL k59_1642192_1 1144305.PMI02_03166 5.28e-88 263.0 COG4221@1|root,COG4221@2|Bacteria,1MUF8@1224|Proteobacteria,2TUSA@28211|Alphaproteobacteria,2K1KC@204457|Sphingomonadales 204457|Sphingomonadales S Belongs to the short-chain dehydrogenases reductases (SDR) family - - - - - - - - - - - - adh_short k59_455724_1 1042376.AFPK01000003_gene1610 3.63e-12 61.2 COG3668@1|root,COG3668@2|Bacteria,4NQ43@976|Bacteroidetes,1I3IS@117743|Flavobacteriia,40790@61432|unclassified Flavobacteriaceae 976|Bacteroidetes S ParE toxin of type II toxin-antitoxin system, parDE - - - ko:K19092 - - - - ko00000,ko02048 - - - ParE_toxin k59_455724_2 1042376.AFPK01000003_gene1611 4.86e-48 154.0 COG3609@1|root,COG3609@2|Bacteria,4NSHD@976|Bacteroidetes,1I46W@117743|Flavobacteriia,407A4@61432|unclassified Flavobacteriaceae 976|Bacteroidetes K Bacterial antitoxin of ParD toxin-antitoxin type II system and RHH - - - ko:K07746 - - - - ko00000,ko02048 - - - ParD_antitoxin k59_794907_1 877418.ATWV01000004_gene1928 0.000476 42.7 COG0050@1|root,COG0050@2|Bacteria,2J5PY@203691|Spirochaetes 203691|Spirochaetes J This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis tuf - - ko:K02358 - - - - ko00000,ko03012,ko03029,ko04147 - - - GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3 k59_794907_3 1121447.JONL01000001_gene735 1.17e-06 50.4 2EG8N@1|root,33A0G@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_794907_4 1380390.JIAT01000014_gene6271 6.56e-07 52.8 COG0566@1|root,COG0566@2|Bacteria,2GJMR@201174|Actinobacteria,4CPWF@84995|Rubrobacteria 84995|Rubrobacteria J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family - - 2.1.1.185 ko:K03218 - - - - ko00000,ko01000,ko03009 - - - SpoU_methylase,SpoU_sub_bind k59_964167_1 1415778.JQMM01000001_gene2075 3.41e-87 260.0 COG0740@1|root,COG0740@2|Bacteria,1MV46@1224|Proteobacteria,1RNR6@1236|Gammaproteobacteria,1J4TT@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins clpP GO:0000502,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006515,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0009056,GO:0009057,GO:0009266,GO:0009314,GO:0009376,GO:0009408,GO:0009628,GO:0009987,GO:0010498,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017171,GO:0019538,GO:0019899,GO:0030163,GO:0031597,GO:0032991,GO:0042623,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0050896,GO:0051117,GO:0051603,GO:0070011,GO:0071704,GO:0140096,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1904949,GO:1905368,GO:1905369 3.4.21.92 ko:K01358 ko04112,ko04212,map04112,map04212 - - - ko00000,ko00001,ko01000,ko01002 - - - CLP_protease k59_964167_2 1027273.GZ77_05675 5.11e-33 124.0 COG1219@1|root,COG1219@2|Bacteria,1MVQK@1224|Proteobacteria,1RN9N@1236|Gammaproteobacteria,1XH3A@135619|Oceanospirillales 135619|Oceanospirillales O ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP clpX - - ko:K03544 ko04112,map04112 - - - ko00000,ko00001,ko03110 - - - AAA_2,ClpB_D2-small,zf-C4_ClpX k59_1754982_1 998674.ATTE01000001_gene4504 6.82e-70 226.0 COG1249@1|root,COG1249@2|Bacteria,1MVVE@1224|Proteobacteria,1RMJT@1236|Gammaproteobacteria,460BQ@72273|Thiotrichales 72273|Thiotrichales C Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain - - 1.6.1.1 ko:K00322 ko00760,ko01100,map00760,map01100 - R00112 RC00001 ko00000,ko00001,ko01000 - - - Pyr_redox_2,Pyr_redox_dim k59_455729_1 309801.trd_0102 7.49e-10 62.0 COG0147@1|root,COG0147@2|Bacteria,2G5M7@200795|Chloroflexi,27XZ8@189775|Thermomicrobia 189775|Thermomicrobia H Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia trpE - 4.1.3.27 ko:K01657 ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025 M00023 R00985,R00986 RC00010,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 - - - Anth_synt_I_N,Chorismate_bind k59_1190140_1 436308.Nmar_1395 1.8e-86 258.0 COG0293@1|root,arCOG00079@2157|Archaea,41SIK@651137|Thaumarchaeota 651137|Thaumarchaeota J Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit rlmE - 2.1.1.166 ko:K02427 - - - - ko00000,ko01000,ko03009 - - - FtsJ k59_1190140_2 436308.Nmar_1394 1.38e-08 55.8 COG1867@1|root,arCOG01219@2157|Archaea,41SAG@651137|Thaumarchaeota 651137|Thaumarchaeota J Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family - - 2.1.1.215,2.1.1.216 ko:K00555 - - - - ko00000,ko01000,ko03016 - - - TRM k59_343055_1 1122603.ATVI01000006_gene657 5.39e-23 99.8 COG2968@1|root,COG2968@2|Bacteria,1RH7T@1224|Proteobacteria,1RP7T@1236|Gammaproteobacteria,1X8DI@135614|Xanthomonadales 135614|Xanthomonadales S Protein of unknown function (DUF541) - - - - - - - - - - - - SIMPL k59_964210_1 525903.Taci_0846 4.53e-13 77.0 COG0037@1|root,COG0037@2|Bacteria,3TAW7@508458|Synergistetes 508458|Synergistetes J Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine tilS - 6.3.4.19 ko:K04075 - - R09597 RC02633,RC02634 ko00000,ko01000,ko03016 - - - ATP_bind_3 k59_1190159_1 680198.SCAB_90201 3.28e-44 157.0 COG0654@1|root,COG0654@2|Bacteria,2GN2W@201174|Actinobacteria 201174|Actinobacteria CH COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases - - - - - - - - - - - - FAD_binding_3 k59_1416021_1 316056.RPC_3609 3.84e-28 110.0 COG1120@1|root,COG1120@2|Bacteria,1MVKU@1224|Proteobacteria,2U058@28211|Alphaproteobacteria,3JZ6Y@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria HP ATPases associated with a variety of cellular activities fecE - 3.6.3.34 ko:K02013 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.14 - - ABC_tran k59_1416021_2 1225785.CM001983_gene2601 4.76e-17 80.1 COG0609@1|root,COG0609@2|Bacteria,1MV9W@1224|Proteobacteria,1RMST@1236|Gammaproteobacteria,2JCGK@204037|Dickeya 1236|Gammaproteobacteria P Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily yiuB - - ko:K02015 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko02000 3.A.1.14 - - FecCD k59_1698565_1 863365.XHC_0399 4.74e-158 463.0 COG0445@1|root,COG0445@2|Bacteria,1MU6F@1224|Proteobacteria,1RMM1@1236|Gammaproteobacteria,1X36F@135614|Xanthomonadales 135614|Xanthomonadales D NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 gidA GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901363 - ko:K03495 - - R08701 RC00053,RC00209,RC00870 ko00000,ko03016,ko03036 - - - GIDA,GIDA_assoc k59_1133633_1 247639.MGP2080_12628 2.03e-65 236.0 COG4774@1|root,COG4774@2|Bacteria,1R6E9@1224|Proteobacteria,1RSF6@1236|Gammaproteobacteria 1236|Gammaproteobacteria P COG1629 Outer membrane receptor proteins, mostly Fe transport - - - - - - - - - - - - Plug,TonB_dep_Rec k59_1755020_2 926550.CLDAP_01600 4.17e-172 488.0 COG2374@1|root,COG2374@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - Endonuclease_1,Exo_endo_phos,LTD k59_1529219_1 95619.PM1_0225445 1.22e-28 118.0 COG0741@1|root,COG0741@2|Bacteria,1MV3F@1224|Proteobacteria,1RMS8@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains) slt GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0006022,GO:0006026,GO:0006027,GO:0006807,GO:0008150,GO:0008152,GO:0008932,GO:0008933,GO:0009056,GO:0009057,GO:0009253,GO:0009274,GO:0016740,GO:0016757,GO:0030203,GO:0030288,GO:0030312,GO:0030313,GO:0031975,GO:0042597,GO:0043170,GO:0044464,GO:0061783,GO:0071704,GO:0071944,GO:1901135,GO:1901136,GO:1901564,GO:1901565,GO:1901575 - ko:K08309 - - - - ko00000,ko01000,ko01011 - GH23 iETEC_1333.ETEC_4747,iPC815.YPO0452 SLT,SLT_L k59_738609_2 1229909.NSED_09190 1.79e-54 171.0 COG2450@1|root,arCOG02263@2157|Archaea,41T6T@651137|Thaumarchaeota 651137|Thaumarchaeota D Pfam:DUF552 - - - ko:K09152 - - - - ko00000 - - - SepF k59_738609_3 1229909.NSED_09185 2.36e-10 61.2 COG0301@1|root,arCOG00038@2157|Archaea,41T1A@651137|Thaumarchaeota 651137|Thaumarchaeota H Thiamine biosynthesis protein (ThiI) - - - - - - - - - - - - DUF814,ThiI k59_1416055_1 316407.85675429 3.4e-44 148.0 COG3133@1|root,COG3133@2|Bacteria,1RFYG@1224|Proteobacteria,1S4YR@1236|Gammaproteobacteria,3XNPC@561|Escherichia 1236|Gammaproteobacteria M Glycine zipper yfgH GO:0005575,GO:0005623,GO:0009279,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0044462,GO:0044464,GO:0071944 - - - - - - - - - - Rick_17kDa_Anti k59_1246806_1 1288494.EBAPG3_28130 9.06e-104 311.0 COG0849@1|root,COG0849@2|Bacteria,1MUSR@1224|Proteobacteria,2VGZP@28216|Betaproteobacteria,372QQ@32003|Nitrosomonadales 28216|Betaproteobacteria D Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring ftsA - - ko:K03590 ko04112,map04112 - - - ko00000,ko00001,ko03036,ko04812 - - - FtsA,SHS2_FTSA k59_1755049_1 330214.NIDE0700 4.82e-69 217.0 COG0451@1|root,COG0451@2|Bacteria,3J0T9@40117|Nitrospirae 40117|Nitrospirae M NmrA-like family - - 1.1.1.219 ko:K00091 - - - - ko00000,ko01000 - - - Epimerase k59_1755049_2 330214.NIDE0699 7.27e-32 118.0 COG2324@1|root,COG2324@2|Bacteria,3J195@40117|Nitrospirae 40117|Nitrospirae S Carotenoid biosynthesis protein - - - - - - - - - - - - Caroten_synth k59_60633_1 1122137.AQXF01000002_gene430 4.79e-82 268.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2TQT0@28211|Alphaproteobacteria 28211|Alphaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K03296,ko:K18138 ko01501,ko01503,map01501,map01503 M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000 2.A.6.2 - - ACR_tran k59_455798_1 1207063.P24_01690 1.27e-99 310.0 COG1529@1|root,COG1529@2|Bacteria,1QTTJ@1224|Proteobacteria,2TQVK@28211|Alphaproteobacteria,2JPB3@204441|Rhodospirillales 204441|Rhodospirillales C COG1529 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL CutL homologs - - 1.3.99.16 ko:K07303 - - - - ko00000,ko01000 - - - Ald_Xan_dh_C2 k59_1529243_1 2340.JV46_22530 7.12e-76 248.0 COG0845@1|root,COG0845@2|Bacteria,1PDUT@1224|Proteobacteria,1RQKD@1236|Gammaproteobacteria,1JBNA@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M HlyD family secretion protein - - - ko:K02005,ko:K13888 - M00709 - - ko00000,ko00002,ko02000 8.A.1 - - HlyD_3,HlyD_D23,OEP k59_1529243_2 1385517.N800_12020 6.58e-37 144.0 COG0577@1|root,COG0577@2|Bacteria,1MW6D@1224|Proteobacteria,1RN49@1236|Gammaproteobacteria,1X36M@135614|Xanthomonadales 135614|Xanthomonadales V FtsX-like permease family - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX k59_681689_1 1121887.AUDK01000018_gene3282 9.43e-46 157.0 COG3507@1|root,COG3507@2|Bacteria,4NDUM@976|Bacteroidetes,1I00E@117743|Flavobacteriia,2NUAY@237|Flavobacterium 976|Bacteroidetes G Belongs to the glycosyl hydrolase 43 family - - - - - - - - - - - - Glyco_hydro_43 k59_681689_2 1549858.MC45_06175 3.8e-09 58.5 COG3534@1|root,COG3534@2|Bacteria,1PPWJ@1224|Proteobacteria,2TWSD@28211|Alphaproteobacteria,2K23Z@204457|Sphingomonadales 204457|Sphingomonadales G Alpha-L-arabinofuranosidase - - 3.2.1.55 ko:K01209 ko00520,map00520 - R01762 - ko00000,ko00001,ko01000 - GH51 - Alpha-L-AF_C k59_1585582_2 1125863.JAFN01000001_gene2974 4.6e-178 504.0 COG1077@1|root,COG1077@2|Bacteria,1MUMW@1224|Proteobacteria,42M1J@68525|delta/epsilon subdivisions,2WIQR@28221|Deltaproteobacteria 28221|Deltaproteobacteria D Cell shape determining protein MreB Mrl mreB - - ko:K03569 - - - - ko00000,ko02048,ko03036,ko04812 1.A.33.1,9.B.157.1 - - MreB_Mbl k59_3943_1 76114.ebA3666 1.84e-85 268.0 COG0843@1|root,COG0843@2|Bacteria,1PVEV@1224|Proteobacteria,2VK5Q@28216|Betaproteobacteria 28216|Betaproteobacteria C Cytochrome C oxidase subunit I coxA2 - 1.9.3.1 ko:K02274 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6 - - COX1 k59_117144_1 1121875.KB907548_gene1529 2.95e-73 240.0 COG0480@1|root,COG0480@2|Bacteria,4NG4H@976|Bacteroidetes,1I0HE@117743|Flavobacteriia 976|Bacteroidetes J Elongation factor G, domain IV fusA2 - - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2 k59_851433_1 1122137.AQXF01000004_gene1397 7.89e-96 292.0 COG0128@1|root,COG0128@2|Bacteria,1MWMK@1224|Proteobacteria,2TR6W@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate aroA GO:0003674,GO:0003824,GO:0003866,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046417,GO:0071704,GO:1901576 2.5.1.19 ko:K00800 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R03460 RC00350 ko00000,ko00001,ko00002,ko01000 - - - EPSP_synthase k59_851433_2 517722.AEUE01000003_gene1668 1.3e-23 91.3 COG4530@1|root,COG4530@2|Bacteria,1N42Z@1224|Proteobacteria,2UDI6@28211|Alphaproteobacteria,2K62H@204457|Sphingomonadales 204457|Sphingomonadales S Protein of unknown function (FYDLN_acid) - - - - - - - - - - - - FYDLN_acid k59_512193_1 103733.JNYO01000029_gene802 5.3e-18 85.9 COG0494@1|root,COG0494@2|Bacteria,2IG9K@201174|Actinobacteria,4E3AD@85010|Pseudonocardiales 201174|Actinobacteria L pfam nudix - - - - - - - - - - - - NUDIX k59_1359751_1 690850.Desaf_3324 2.44e-20 89.4 COG2518@1|root,COG2518@2|Bacteria,1MXQC@1224|Proteobacteria,42QSI@68525|delta/epsilon subdivisions,2WMNJ@28221|Deltaproteobacteria,2M7VK@213115|Desulfovibrionales 28221|Deltaproteobacteria J Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins pcm-2 - 2.1.1.77 ko:K00573 - - - - ko00000,ko01000 - - - PCMT k59_1359751_2 1501230.ET33_03590 2.93e-08 55.1 COG0589@1|root,COG0589@2|Bacteria,1VEJR@1239|Firmicutes,4HNHG@91061|Bacilli,26XFT@186822|Paenibacillaceae 91061|Bacilli T Belongs to the universal stress protein A family uspA - - - - - - - - - - - Usp k59_512194_1 584708.Apau_1863 3.83e-30 122.0 COG4907@1|root,COG4907@2|Bacteria,3TA8F@508458|Synergistetes 508458|Synergistetes S membrane protein (DUF2207) - - - - - - - - - - - - DUF2207 k59_512194_2 1123504.JQKD01000013_gene1012 2.95e-06 49.7 COG0705@1|root,COG0705@2|Bacteria,1MYFP@1224|Proteobacteria,2VQB1@28216|Betaproteobacteria,4AHHN@80864|Comamonadaceae 28216|Betaproteobacteria S Eukaryotic integral membrane protein (DUF1751) - - - - - - - - - - - - Rhomboid k59_455820_1 1056512.D515_01714 5.32e-79 244.0 COG4989@1|root,COG4989@2|Bacteria,1MY3G@1224|Proteobacteria,1RRIC@1236|Gammaproteobacteria,1Y0IF@135623|Vibrionales 135623|Vibrionales S Aldo/keto reductase family - - - - - - - - - - - - Aldo_ket_red k59_1642294_1 44060.JODL01000020_gene4928 1.35e-68 223.0 COG0044@1|root,COG0044@2|Bacteria,2GK4A@201174|Actinobacteria 201174|Actinobacteria F Dihydropyrimidinase hyuA - 3.5.2.2 ko:K01464 ko00240,ko00410,ko00770,ko00983,ko01100,map00240,map00410,map00770,map00983,map01100 M00046 R02269,R03055,R08227 RC00632,RC00680 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Amidohydro_1 k59_794974_1 1096930.L284_16070 2.04e-20 91.3 COG3249@1|root,COG3249@2|Bacteria,1R81G@1224|Proteobacteria,2U1EP@28211|Alphaproteobacteria,2K0TT@204457|Sphingomonadales 204457|Sphingomonadales S protein conserved in bacteria - - - - - - - - - - - - - k59_794974_2 158500.BV97_01322 5.02e-38 137.0 COG0150@1|root,COG0150@2|Bacteria,1MURG@1224|Proteobacteria,2TR6G@28211|Alphaproteobacteria,2K07H@204457|Sphingomonadales 204457|Sphingomonadales F Phosphoribosylformylglycinamidine cyclo-ligase purM - 6.3.3.1 ko:K01933 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04208 RC01100 ko00000,ko00001,ko00002,ko01000 - - - AIRS,AIRS_C k59_568876_1 1229909.NSED_09060 1.46e-23 94.7 COG1468@1|root,arCOG00790@2157|Archaea,41T4T@651137|Thaumarchaeota 651137|Thaumarchaeota V CRISPR-associated protein Cas4 - - 3.1.12.1 ko:K07464 - - - - ko00000,ko01000,ko02048 - - - - k59_568876_2 1229909.NSED_09055 4.17e-24 93.2 arCOG10411@1|root,arCOG10411@2157|Archaea,41T7X@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1190267_1 879212.DespoDRAFT_00815 0.000167 47.4 COG1639@1|root,COG1639@2|Bacteria,1RAH3@1224|Proteobacteria,42PRF@68525|delta/epsilon subdivisions,2WMIQ@28221|Deltaproteobacteria,2MJ5G@213118|Desulfobacterales 28221|Deltaproteobacteria T PFAM HDOD domain - - - - - - - - - - - - HDOD k59_343122_1 1038922.PflQ2_0213 5.53e-85 265.0 COG0004@1|root,COG0004@2|Bacteria,1NR9F@1224|Proteobacteria,1RNKF@1236|Gammaproteobacteria,1YP7U@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria U Ammonium transporter amtB - - ko:K03320 - - - - ko00000,ko02000 1.A.11 - - Ammonium_transp k59_286572_2 314254.OA2633_11955 5.78e-166 469.0 COG0491@1|root,COG0491@2|Bacteria,1MURA@1224|Proteobacteria,2TR1F@28211|Alphaproteobacteria,43WY5@69657|Hyphomonadaceae 28211|Alphaproteobacteria S COG0491 Zn-dependent hydrolases, including glyoxylases - - - - - - - - - - - - Lactamase_B k59_286572_3 1280948.HY36_17430 1.42e-18 82.4 COG0640@1|root,COG0640@2|Bacteria,1N72Q@1224|Proteobacteria,2UFSY@28211|Alphaproteobacteria,43YVS@69657|Hyphomonadaceae 28211|Alphaproteobacteria K helix_turn_helix, Arsenical Resistance Operon Repressor bigR - - - - - - - - - - - HTH_20,HTH_5 k59_286572_4 1122137.AQXF01000002_gene650 2.29e-130 387.0 COG1757@1|root,COG1757@2|Bacteria,1MVDF@1224|Proteobacteria,2TU82@28211|Alphaproteobacteria 28211|Alphaproteobacteria C Na H antiporter - - - ko:K03315 - - - - ko00000,ko02000 2.A.35 - - Na_H_antiporter k59_1190277_2 926569.ANT_02260 1.3e-16 74.3 COG2740@1|root,COG2740@2|Bacteria,2G72H@200795|Chloroflexi 200795|Chloroflexi K Protein of unknown function (DUF448) - - - ko:K07742 - - - - ko00000 - - - DUF448 k59_3967_1 234267.Acid_1198 8.17e-94 296.0 COG1321@1|root,COG1321@2|Bacteria 2|Bacteria K iron dependent repressor nagC - - ko:K02003,ko:K02565,ko:K15545 - M00258 - - ko00000,ko00002,ko02000,ko03000 3.A.1 - - HTH_IclR,MarR,ROK k59_1642313_1 1123060.JONP01000032_gene1861 1.25e-41 138.0 COG5507@1|root,COG5507@2|Bacteria,1RH3Q@1224|Proteobacteria,2U9SM@28211|Alphaproteobacteria,2JWSY@204441|Rhodospirillales 204441|Rhodospirillales S NIPSNAP - - - - - - - - - - - - NIPSNAP k59_1642313_2 1415754.JQMK01000002_gene3572 5.72e-14 68.2 COG1225@1|root,COG1225@2|Bacteria,1RD4R@1224|Proteobacteria,1RQ7F@1236|Gammaproteobacteria,46AS0@72275|Alteromonadaceae 1236|Gammaproteobacteria O Redoxin bcp - 1.11.1.15 ko:K03564 - - - - ko00000,ko01000 - - - AhpC-TSA k59_286575_1 882378.RBRH_03219 3.59e-76 253.0 COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,2VJIV@28216|Betaproteobacteria,1K1JU@119060|Burkholderiaceae 28216|Betaproteobacteria F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides nrdA GO:0000166,GO:0003674,GO:0003824,GO:0004748,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005971,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009262,GO:0009263,GO:0009987,GO:0016491,GO:0016725,GO:0016728,GO:0018130,GO:0019438,GO:0019637,GO:0032991,GO:0034641,GO:0034654,GO:0036094,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046483,GO:0055086,GO:0055114,GO:0061731,GO:0071704,GO:0090407,GO:0097159,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902494,GO:1990204 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - ATP-cone,Ribonuc_red_lgC,Ribonuc_red_lgN k59_343127_1 886293.Sinac_7570 7.75e-39 144.0 COG2242@1|root,COG2242@2|Bacteria,2J25Y@203682|Planctomycetes 203682|Planctomycetes H protein methyltransferase activity - - - - - - - - - - - - - k59_851466_1 76114.ebD118 5.65e-09 55.1 COG0745@1|root,COG0745@2|Bacteria,1RD7E@1224|Proteobacteria,2VU99@28216|Betaproteobacteria,2KZ14@206389|Rhodocyclales 206389|Rhodocyclales T cheY-homologous receiver domain - - - ko:K11443 ko02020,ko04112,map02020,map04112 M00511 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg k59_1698683_1 436308.Nmar_1236 3.36e-18 75.9 COG2093@1|root,arCOG04077@2157|Archaea,41SVE@651137|Thaumarchaeota 651137|Thaumarchaeota K Transcription elongation factor Spt4 spt4 - 2.7.7.6 ko:K03050 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00184 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021 - - - Spt4 k59_1698683_2 1229909.NSED_06925 6.28e-76 230.0 COG1095@1|root,arCOG00675@2157|Archaea,41SGF@651137|Thaumarchaeota 651137|Thaumarchaeota K DNA-directed RNA polymerase - - 2.7.7.6 ko:K03049 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00184 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021 - - - S1,SHS2_Rpb7-N k59_286584_1 1121937.AUHJ01000005_gene2183 2.76e-82 267.0 COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MUT8@1224|Proteobacteria,1RN6R@1236|Gammaproteobacteria,469XN@72275|Alteromonadaceae 1236|Gammaproteobacteria G PEP-utilising enzyme, TIM barrel domain ppdK - 2.7.1.202,2.7.3.9,2.7.9.1,2.7.9.2 ko:K01006,ko:K01007,ko:K02768,ko:K08483,ko:K11183 ko00051,ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,ko02060,map00051,map00620,map00680,map00710,map00720,map01100,map01120,map01200,map02060 M00169,M00171,M00172,M00173,M00273,M00374 R00199,R00206,R03232 RC00002,RC00015,RC00017,RC03206 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.2.1,8.A.7 - - PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C,PPDK_N,PTS-HPr,PTS_EIIA_2 k59_1190296_2 440512.C211_05725 4.57e-30 122.0 28HB2@1|root,2Z7N8@2|Bacteria,1P4RV@1224|Proteobacteria,1RN0X@1236|Gammaproteobacteria 1236|Gammaproteobacteria M isomerase cti - - - - - - - - - - - CTI k59_399417_1 1386089.N865_00075 2.62e-09 60.1 COG3682@1|root,COG3682@2|Bacteria,2IIIT@201174|Actinobacteria,4FHMJ@85021|Intrasporangiaceae 201174|Actinobacteria K Transcriptional regulator blaI GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0042221,GO:0046677,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2000112,GO:2001141 - - - - - - - - - - Penicillinase_R k59_738681_1 323848.Nmul_A0705 1.01e-73 231.0 COG0407@1|root,COG0407@2|Bacteria,1MUG1@1224|Proteobacteria,2VHC2@28216|Betaproteobacteria,372TZ@32003|Nitrosomonadales 28216|Betaproteobacteria H Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III hemE - 4.1.1.37 ko:K01599 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R03197,R04972 RC00872 ko00000,ko00001,ko00002,ko01000 - - - URO-D k59_851482_2 187272.Mlg_0270 1.26e-162 478.0 COG0508@1|root,COG0508@2|Bacteria,1MU7K@1224|Proteobacteria,1RNPT@1236|Gammaproteobacteria,1WW8D@135613|Chromatiales 135613|Chromatiales C The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) - - 2.3.1.12 ko:K00627 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200 M00307 R00209,R02569 RC00004,RC02742,RC02857 br01601,ko00000,ko00001,ko00002,ko01000 - - - 2-oxoacid_dh,Biotin_lipoyl,E3_binding k59_3989_2 323850.Shew_0982 7.7e-130 382.0 COG0624@1|root,COG0624@2|Bacteria,1MWJS@1224|Proteobacteria,1RZXV@1236|Gammaproteobacteria 1236|Gammaproteobacteria E COG0624 Acetylornithine deacetylase Succinyl-diaminopimelate desuccinylase and related deacylases - - - ko:K13049 - - - - ko00000,ko01000,ko01002 - - - M20_dimer,Peptidase_M20,Peptidase_M28 k59_1133773_1 1298863.AUEP01000019_gene3529 1.84e-58 190.0 COG0500@1|root,COG2226@2|Bacteria,2GJSF@201174|Actinobacteria,4DT5X@85009|Propionibacteriales 201174|Actinobacteria Q ubiE/COQ5 methyltransferase family - - - - - - - - - - - - Methyltransf_11 k59_1077033_1 631362.Thi970DRAFT_00535 4.59e-41 141.0 COG2920@1|root,COG2920@2|Bacteria,1N6BU@1224|Proteobacteria,1S6FJ@1236|Gammaproteobacteria,1WYPC@135613|Chromatiales 135613|Chromatiales P part of a sulfur-relay system - - - ko:K11179 ko04122,map04122 - - - ko00000,ko00001,ko01000,ko03016 - - - DsrC k59_399429_1 215803.DB30_5516 4.68e-46 163.0 COG0506@1|root,COG0506@2|Bacteria,1R8VR@1224|Proteobacteria,42P21@68525|delta/epsilon subdivisions,2WJU2@28221|Deltaproteobacteria,2YX6B@29|Myxococcales 28221|Deltaproteobacteria C Proline dehydrogenase - - - ko:K00318 ko00330,ko01100,ko01110,ko01130,map00330,map01100,map01110,map01130 - R10507 RC00083 ko00000,ko00001,ko01000 - - - Pro_dh k59_907699_1 314285.KT71_04155 6.45e-07 51.6 COG0793@1|root,COG0793@2|Bacteria,1MU39@1224|Proteobacteria,1RMSR@1236|Gammaproteobacteria,1J8YH@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M tail specific protease ctpA - 3.4.21.102 ko:K03797 - - - - ko00000,ko01000,ko01002 - - - PDZ_2,Peptidase_S41 k59_907699_2 1265313.HRUBRA_01517 6.67e-59 192.0 COG4942@1|root,COG4942@2|Bacteria,1MY3E@1224|Proteobacteria,1RPQP@1236|Gammaproteobacteria,1J4S5@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria D COG4942 Membrane-bound metallopeptidase envC GO:0000920,GO:0001896,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008219,GO:0009273,GO:0009314,GO:0009628,GO:0009987,GO:0012501,GO:0016020,GO:0016787,GO:0030288,GO:0030313,GO:0031975,GO:0032153,GO:0042221,GO:0042493,GO:0042546,GO:0042597,GO:0043085,GO:0044085,GO:0044093,GO:0044464,GO:0050790,GO:0050896,GO:0051301,GO:0051336,GO:0051345,GO:0065007,GO:0065009,GO:0071554,GO:0071840,GO:0071944 - - - - - - - - - - Peptidase_M23 k59_173640_1 469383.Cwoe_0843 4.34e-84 265.0 COG1884@1|root,COG1884@2|Bacteria,2GM65@201174|Actinobacteria,4CPEB@84995|Rubrobacteria 84995|Rubrobacteria I Methylmalonyl-CoA mutase - - 5.4.99.2 ko:K01848 ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200 M00375,M00376,M00741 R00833 RC00395 ko00000,ko00001,ko00002,ko01000 - - - MM_CoA_mutase k59_681747_1 1122137.AQXF01000007_gene3495 9.63e-154 459.0 COG0577@1|root,COG0577@2|Bacteria,1NREW@1224|Proteobacteria,2U1KH@28211|Alphaproteobacteria 28211|Alphaproteobacteria V ABC-type antimicrobial peptide transport system, permease component - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_351104_1 595494.Tola_1849 5.04e-09 58.5 COG2194@1|root,COG2194@2|Bacteria,1MWS7@1224|Proteobacteria,1RMNG@1236|Gammaproteobacteria,1Y3W4@135624|Aeromonadales 135624|Aeromonadales S Domain of unknown function (DUF1705) - - 2.7.8.43 ko:K03760 ko01503,map01503 M00722 R11555,R11556,R11557 RC00002 ko00000,ko00001,ko00002,ko01000,ko01005 - - - DUF1705,Sulfatase k59_351104_2 1411685.U062_00831 1.95e-20 82.8 2CETI@1|root,2ZN6G@2|Bacteria,1P6WK@1224|Proteobacteria,1STF4@1236|Gammaproteobacteria,1JBI1@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - DUF3094 k59_407114_2 556268.OFAG_00807 1.79e-09 58.9 2936R@1|root,2ZQPT@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_407116_1 502025.Hoch_0525 7.97e-11 66.2 COG0457@1|root,COG4783@1|root,COG0457@2|Bacteria,COG4783@2|Bacteria,1Q1X1@1224|Proteobacteria,437J0@68525|delta/epsilon subdivisions,2WYKS@28221|Deltaproteobacteria,2Z2BC@29|Myxococcales 28221|Deltaproteobacteria S Oxygen tolerance - - - - - - - - - - - - BatD k59_859797_1 1123269.NX02_15490 2.39e-199 580.0 COG1629@1|root,COG1629@2|Bacteria,1QUTW@1224|Proteobacteria,2TW7F@28211|Alphaproteobacteria,2KECH@204457|Sphingomonadales 204457|Sphingomonadales P TonB-dependent Receptor Plug Domain - - - - - - - - - - - - Plug,TonB_dep_Rec k59_181188_1 1356852.N008_14405 2.18e-101 316.0 COG0438@1|root,COG0438@2|Bacteria,4PKQN@976|Bacteroidetes,47K56@768503|Cytophagia 976|Bacteroidetes M PFAM glycogen synthase - - 2.4.1.11 ko:K00693 ko00500,ko01100,ko04151,ko04152,ko04910,ko04922,ko04931,map00500,map01100,map04151,map04152,map04910,map04922,map04931 - R00292 RC00005 ko00000,ko00001,ko01000,ko01003 - GT3 - Glycogen_syn k59_11969_1 1121937.AUHJ01000001_gene361 1.11e-67 209.0 COG1853@1|root,COG1853@2|Bacteria,1RGYM@1224|Proteobacteria,1S97V@1236|Gammaproteobacteria,468UV@72275|Alteromonadaceae 1236|Gammaproteobacteria S Flavin reductase like domain - - - - - - - - - - - - Flavin_Reduct k59_1423623_1 467661.RKLH11_3924 4.37e-111 326.0 COG2801@1|root,COG2963@1|root,COG2801@2|Bacteria,COG2963@2|Bacteria,1PBHA@1224|Proteobacteria,2TRQF@28211|Alphaproteobacteria 28211|Alphaproteobacteria L COG2801 Transposase and inactivated derivatives - - - ko:K07497 - - - - ko00000 - - - HTH_32,rve,rve_3 k59_1537199_1 1128912.GMES_1972 6.75e-08 52.8 COG0427@1|root,COG1670@1|root,COG0427@2|Bacteria,COG1670@2|Bacteria,1MUGE@1224|Proteobacteria,1RP19@1236|Gammaproteobacteria,46429@72275|Alteromonadaceae 1236|Gammaproteobacteria C acetyl-CoA hydrolase - - - ko:K18288 ko00660,map00660 - R02407,R10600 RC00012,RC00014 ko00000,ko00001,ko01000 - - - AcetylCoA_hyd_C,AcetylCoA_hydro,Acetyltransf_1,Acetyltransf_3 k59_1537199_2 1415778.JQMM01000001_gene1424 1.12e-39 139.0 COG3087@1|root,COG3087@2|Bacteria,1MYFG@1224|Proteobacteria,1SD3J@1236|Gammaproteobacteria,1J6IM@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria D COG3087 Cell division protein ftsN - - ko:K03591 - - - - ko00000,ko03036 - - - SPOR k59_11970_1 5888.CAK67113 7.08e-05 47.4 COG0484@1|root,KOG0603@1|root,KOG0603@2759|Eukaryota,KOG0712@2759|Eukaryota 2759|Eukaryota O heat shock protein binding SCJ1 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005783,GO:0005788,GO:0005829,GO:0006457,GO:0006508,GO:0006511,GO:0006807,GO:0006950,GO:0006986,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0010033,GO:0010243,GO:0010498,GO:0012505,GO:0019538,GO:0019941,GO:0030163,GO:0030433,GO:0030544,GO:0031072,GO:0031974,GO:0033554,GO:0034620,GO:0034975,GO:0034976,GO:0035966,GO:0035967,GO:0036503,GO:0042221,GO:0043161,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044422,GO:0044424,GO:0044432,GO:0044444,GO:0044446,GO:0044464,GO:0050896,GO:0051087,GO:0051603,GO:0051716,GO:0070013,GO:0070887,GO:0071310,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901698 2.7.11.1,2.7.11.11 ko:K03686,ko:K04345,ko:K04373,ko:K14002 ko01522,ko04010,ko04014,ko04020,ko04024,ko04062,ko04113,ko04114,ko04138,ko04140,ko04141,ko04150,ko04211,ko04213,ko04261,ko04270,ko04310,ko04340,ko04341,ko04371,ko04530,ko04540,ko04611,ko04713,ko04714,ko04720,ko04722,ko04723,ko04724,ko04725,ko04726,ko04727,ko04728,ko04740,ko04742,ko04750,ko04910,ko04911,ko04912,ko04913,ko04914,ko04915,ko04916,ko04918,ko04919,ko04921,ko04922,ko04923,ko04924,ko04925,ko04926,ko04927,ko04931,ko04934,ko04961,ko04962,ko04970,ko04971,ko04976,ko05012,ko05020,ko05030,ko05031,ko05032,ko05110,ko05146,ko05165,ko05166,ko05169,ko05200,ko05203,ko05205,ko05414,map01522,map04010,map04014,map04020,map04024,map04062,map04113,map04114,map04138,map04140,map04141,map04150,map04211,map04213,map04261,map04270,map04310,map04340,map04341,map04371,map04530,map04540,map04611,map04713,map04714,map04720,map04722,map04723,map04724,map04725,map04726,map04727,map04728,map04740,map04742,map04750,map04910,map04911,map04912,map04913,map04914,map04915,map04916,map04918,map04919,map04921,map04922,map04923,map04924,map04925,map04926,map04927,map04931,map04934,map04961,map04962,map04970,map04971,map04976,map05012,map05020,map05030,map05031,map05032,map05110,map05146,map05165,map05166,map05169,map05200,map05203,map05205,map05414 M00695 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko03019,ko03029,ko03036,ko03110 - - - DnaJ,DnaJ_C,DnaJ_CXXCXGXG,Pkinase k59_1762857_1 1313172.YM304_27420 9.85e-62 201.0 COG0821@1|root,COG0821@2|Bacteria,2GK2S@201174|Actinobacteria,4CMRA@84992|Acidimicrobiia 84992|Acidimicrobiia I Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate ispG - 1.17.7.1,1.17.7.3 ko:K03526 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R08689,R10859 RC01486 ko00000,ko00001,ko00002,ko01000 - - - GcpE k59_463512_1 1232683.ADIMK_1860 3.93e-33 119.0 2E445@1|root,32Z0E@2|Bacteria,1N7FY@1224|Proteobacteria,1SDJE@1236|Gammaproteobacteria,468QW@72275|Alteromonadaceae 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_463512_2 317025.Tcr_0271 3e-19 87.0 COG0457@1|root,COG3271@1|root,COG0457@2|Bacteria,COG3271@2|Bacteria,1RA3D@1224|Proteobacteria,1S2EC@1236|Gammaproteobacteria,460F8@72273|Thiotrichales 72273|Thiotrichales S Peptidase_C39 like family - - - - - - - - - - - - Peptidase_C39_2 k59_519675_1 316407.85676701 9.81e-82 260.0 COG0480@1|root,COG0480@2|Bacteria,1MUCV@1224|Proteobacteria,1RNSZ@1236|Gammaproteobacteria,3XMEB@561|Escherichia 1236|Gammaproteobacteria J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome fusA GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2 k59_463515_1 243231.GSU2285 3.12e-88 286.0 COG1480@1|root,COG1480@2|Bacteria,1NCY5@1224|Proteobacteria,42MI9@68525|delta/epsilon subdivisions,2WJI1@28221|Deltaproteobacteria,43UC4@69541|Desulfuromonadales 28221|Deltaproteobacteria S Metal-dependent phosphohydrolase - - - ko:K07037 - - - - ko00000 - - - 7TM-7TMR_HD,7TMR-HDED,HD k59_237256_1 1144310.PMI07_005926 1.24e-36 138.0 COG0477@1|root,COG0477@2|Bacteria,1MU46@1224|Proteobacteria,2TQVP@28211|Alphaproteobacteria,4B93A@82115|Rhizobiaceae 28211|Alphaproteobacteria EGP Permeases of the major facilitator superfamily MA20_40020 - - - - - - - - - - - MFS_1,Sugar_tr k59_1537221_2 1229909.NSED_07215 7.92e-72 226.0 COG0358@1|root,arCOG04281@2157|Archaea,41S75@651137|Thaumarchaeota 651137|Thaumarchaeota L DNA primase dnaG - - ko:K02316 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - Toprim_4 k59_1650115_1 1096930.L284_21885 7.2e-92 288.0 COG1629@1|root,COG4771@2|Bacteria,1MXY7@1224|Proteobacteria,2TV9S@28211|Alphaproteobacteria 28211|Alphaproteobacteria P receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_68881_1 316407.85674290 7.61e-116 356.0 COG0060@1|root,COG0060@2|Bacteria,1MVBQ@1224|Proteobacteria,1RMTF@1236|Gammaproteobacteria,3XNGC@561|Escherichia 1236|Gammaproteobacteria J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) ileS GO:0003674,GO:0003824,GO:0004812,GO:0004822,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006428,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.5 ko:K01870 ko00970,map00970 M00359,M00360 R03656 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iG2583_1286.G2583_0027,iPC815.YPO0475 Anticodon_1,tRNA-synt_1,zf-FPG_IleRS k59_576536_2 1192034.CAP_0017 4.61e-16 79.0 COG1595@1|root,COG1595@2|Bacteria,1N38X@1224|Proteobacteria,42U8K@68525|delta/epsilon subdivisions,2WPZ9@28221|Deltaproteobacteria,2YV95@29|Myxococcales 28221|Deltaproteobacteria K Belongs to the sigma-70 factor family. ECF subfamily - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 k59_859844_1 1121935.AQXX01000142_gene2326 4.21e-20 92.8 28HC9@1|root,2Z7P5@2|Bacteria,1R4BH@1224|Proteobacteria,1RSAN@1236|Gammaproteobacteria,1XNEQ@135619|Oceanospirillales 135619|Oceanospirillales - - - - - - - - - - - - - - - k59_859844_2 1117647.M5M_18165 6.48e-79 242.0 28I6Z@1|root,2Z89U@2|Bacteria,1R8YM@1224|Proteobacteria,1S0GG@1236|Gammaproteobacteria 1236|Gammaproteobacteria S von Willebrand factor (vWF) type A domain - - - - - - - - - - - - - k59_689466_2 1230476.C207_03286 4.11e-25 105.0 COG0457@1|root,COG3914@1|root,COG0457@2|Bacteria,COG3914@2|Bacteria,1MVMG@1224|Proteobacteria,2TRVB@28211|Alphaproteobacteria,3JR8N@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria O Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - - - - - - - - - - Glyco_transf_41,Methyltransf_23,TPR_1,TPR_11,TPR_16,TPR_2,TPR_8 k59_1762881_1 45351.EDO41770 3.55e-24 104.0 KOG1610@1|root,KOG1610@2759|Eukaryota,38BV4@33154|Opisthokonta,3BA6X@33208|Metazoa 33208|Metazoa Q retinol dehydrogenase activity RDH5 GO:0001523,GO:0003008,GO:0003674,GO:0003824,GO:0004745,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005730,GO:0005737,GO:0005783,GO:0005788,GO:0005789,GO:0005829,GO:0006066,GO:0006082,GO:0006091,GO:0006629,GO:0006694,GO:0006702,GO:0006706,GO:0006710,GO:0006720,GO:0006721,GO:0007600,GO:0007601,GO:0008150,GO:0008152,GO:0008202,GO:0008209,GO:0008610,GO:0009055,GO:0009056,GO:0009058,GO:0009987,GO:0010817,GO:0012505,GO:0016020,GO:0016042,GO:0016101,GO:0016229,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0022900,GO:0031974,GO:0031981,GO:0031984,GO:0032501,GO:0032787,GO:0033764,GO:0034308,GO:0034754,GO:0042175,GO:0042445,GO:0042446,GO:0042447,GO:0042572,GO:0042573,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044297,GO:0044422,GO:0044424,GO:0044425,GO:0044428,GO:0044432,GO:0044444,GO:0044446,GO:0044464,GO:0047035,GO:0050877,GO:0050953,GO:0055114,GO:0065007,GO:0065008,GO:0070013,GO:0071704,GO:0098827,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576,GO:1901615 1.1.1.105,1.1.1.239,1.1.1.315,1.1.1.62 ko:K00061,ko:K11154,ko:K13369 ko00140,ko00830,ko01100,map00140,map00830,map01100 - R01836,R02124,R02352,R02353,R03048,R04681,R04682,R08382,R08945,R08980 RC00127,RC00261,RC00649 ko00000,ko00001,ko01000 - - - adh_short k59_237267_1 1121935.AQXX01000098_gene1657 2.62e-53 191.0 COG0823@1|root,COG0823@2|Bacteria,1R3VN@1224|Proteobacteria,1RNKG@1236|Gammaproteobacteria,1XNC8@135619|Oceanospirillales 135619|Oceanospirillales U COG0823 Periplasmic component of the Tol biopolymer transport system - - - - - - - - - - - - PD40 k59_632987_1 1096930.L284_22165 3.03e-47 175.0 COG1629@1|root,COG4771@2|Bacteria,1MWKN@1224|Proteobacteria,2U3VD@28211|Alphaproteobacteria,2K0FN@204457|Sphingomonadales 204457|Sphingomonadales P Protein involved in receptor activity and transport - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_971412_1 519989.ECTPHS_13088 1.38e-99 295.0 COG0092@1|root,COG0092@2|Bacteria,1MUAI@1224|Proteobacteria,1RN0P@1236|Gammaproteobacteria,1WVYC@135613|Chromatiales 135613|Chromatiales J Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation rpsC - - ko:K02982 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - KH_2,Ribosomal_S3_C k59_689476_1 460265.Mnod_6362 2.14e-67 212.0 COG0846@1|root,COG0846@2|Bacteria,1MUK1@1224|Proteobacteria,2TV1Q@28211|Alphaproteobacteria,1JSZU@119045|Methylobacteriaceae 28211|Alphaproteobacteria K NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form cobB - - ko:K12410 - - - - ko00000,ko01000 - - - SIR2 k59_1537251_1 330214.NIDE4159 2.24e-27 102.0 2E4SV@1|root,32ZM7@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - PGPGW k59_1537251_2 1158318.ATXC01000001_gene1026 3.5e-37 142.0 COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,2G3XK@200783|Aquificae 200783|Aquificae L 5'-3' exonuclease - GO:0003674,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008409,GO:0009058,GO:0009059,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901362,GO:1901576 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N,DNA_pol_A k59_181260_2 1122137.AQXF01000001_gene2822 3.36e-73 224.0 COG0810@1|root,COG0810@2|Bacteria,1PEDH@1224|Proteobacteria,2UEEK@28211|Alphaproteobacteria 28211|Alphaproteobacteria M Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins - - - ko:K03832 - - - - ko00000,ko02000 2.C.1.1 - - TonB_C k59_1537270_1 1459636.NTE_02862 3.3e-66 218.0 arCOG00144@1|root,arCOG00144@2157|Archaea 2157|Archaea S Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 k59_1254670_1 429009.Adeg_1891 5.69e-89 275.0 COG0174@1|root,COG0174@2|Bacteria,1TNZA@1239|Firmicutes,2489S@186801|Clostridia,42FXP@68295|Thermoanaerobacterales 186801|Clostridia E Glutamine synthetase, catalytic domain - - 6.3.1.2 ko:K01915 ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 - R00253 RC00010,RC02798 ko00000,ko00001,ko01000,ko04147 - - - Gln-synt_C,Gln-synt_N k59_633027_1 716928.AJQT01000025_gene3995 4.29e-15 77.0 COG0743@1|root,COG0743@2|Bacteria,1MU4G@1224|Proteobacteria,2TSD1@28211|Alphaproteobacteria,4B7JF@82115|Rhizobiaceae 28211|Alphaproteobacteria I Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) dxr GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006721,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016114,GO:0016491,GO:0016614,GO:0016616,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0030145,GO:0030604,GO:0032787,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046490,GO:0046872,GO:0046914,GO:0048037,GO:0050661,GO:0050662,GO:0051483,GO:0051484,GO:0055114,GO:0070402,GO:0071704,GO:0090407,GO:0097159,GO:1901135,GO:1901265,GO:1901363,GO:1901576 1.1.1.267 ko:K00099 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05688 RC01452 ko00000,ko00001,ko00002,ko01000 - - - DXPR_C,DXP_redisom_C,DXP_reductoisom k59_633027_2 378806.STAUR_3284 2.8e-43 160.0 COG0750@1|root,COG0750@2|Bacteria,1MU91@1224|Proteobacteria,42NJ0@68525|delta/epsilon subdivisions,2WJ7A@28221|Deltaproteobacteria,2YTYT@29|Myxococcales 28221|Deltaproteobacteria M Peptidase family M50 rseP - - ko:K11749 ko02024,ko04112,map02024,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - PDZ,PDZ_2,Peptidase_M50 k59_181289_1 1122180.Lokhon_02940 1e-13 72.4 COG3743@1|root,COG3743@2|Bacteria,1N76A@1224|Proteobacteria,2U93Q@28211|Alphaproteobacteria,2P96M@245186|Loktanella 28211|Alphaproteobacteria S NADH ubiquinone oxidoreductase 41 kD complex I subunit - - - - - - - - - - - - - k59_1762923_1 1415778.JQMM01000001_gene1960 4.02e-68 216.0 COG1090@1|root,COG1090@2|Bacteria,1MUB4@1224|Proteobacteria,1RN6A@1236|Gammaproteobacteria,1J5PT@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S nucleoside-diphosphate sugar epimerase yfcH - - ko:K07071 - - - - ko00000 - - - DUF1731,Epimerase k59_463578_1 1283300.ATXB01000001_gene1168 6.59e-117 343.0 COG0369@1|root,COG0369@2|Bacteria,1NCKQ@1224|Proteobacteria,1RR4U@1236|Gammaproteobacteria 1236|Gammaproteobacteria P PFAM Oxidoreductase FAD NAD(P)-binding - - 1.14.13.208,1.18.1.2,1.8.1.2 ko:K00380,ko:K02641,ko:K15511 ko00195,ko00362,ko00920,ko01100,ko01120,map00195,map00362,map00920,map01100,map01120 M00176 R00858,R09555 RC00065,RC01739 ko00000,ko00001,ko00002,ko00194,ko01000 - - - FAD_binding_6,Fer4,NAD_binding_1 k59_463578_2 1120953.AUBH01000002_gene1458 1.09e-42 144.0 COG4657@1|root,COG4657@2|Bacteria,1MU8X@1224|Proteobacteria,1RQDN@1236|Gammaproteobacteria,464YB@72275|Alteromonadaceae 1236|Gammaproteobacteria C Part of a membrane complex involved in electron transport rnfA - - ko:K03617 - - - - ko00000 - - - Rnf-Nqr k59_859904_1 1123508.JH636444_gene5317 1.86e-16 81.6 COG4422@1|root,COG4422@2|Bacteria,2IY1I@203682|Planctomycetes 2|Bacteria S COG4422 Bacteriophage protein gp37 - - - - - - - - - - - - DUF5131 k59_1537296_1 1121377.KB906399_gene1475 1.46e-34 130.0 COG0697@1|root,COG0697@2|Bacteria,1WMPY@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus EG EamA-like transporter family - - - - - - - - - - - - EamA k59_915453_1 1499967.BAYZ01000025_gene285 1.38e-51 181.0 COG0018@1|root,COG0018@2|Bacteria,2NP0H@2323|unclassified Bacteria 2|Bacteria J Arginyl tRNA synthetase N terminal dom argS GO:0003674,GO:0003824,GO:0004812,GO:0004814,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006420,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.19 ko:K01887 ko00970,map00970 M00359,M00360 R03646 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - iECABU_c1320.ECABU_c21380,iECNA114_1301.ECNA114_1940,iECSE_1348.ECSE_2111,iECSF_1327.ECSF_1736,iEcolC_1368.EcolC_1756,iJN746.PP_5089,iLF82_1304.LF82_0128,iNRG857_1313.NRG857_09405,iUMNK88_1353.UMNK88_2348,ic_1306.c2291 Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d k59_12073_2 436308.Nmar_0713 6.99e-69 212.0 arCOG10536@1|root,arCOG10536@2157|Archaea 2157|Archaea S Polyketide cyclase / dehydrase and lipid transport - - - - - - - - - - - - Polyketide_cyc2 k59_12073_3 1229909.NSED_03685 7.35e-55 186.0 arCOG05201@1|root,arCOG05201@2157|Archaea 2157|Archaea E Transglutaminase-like superfamily - - - - - - - - - - - - - k59_351237_1 1229909.NSED_06860 1.77e-127 382.0 COG0464@1|root,arCOG01308@2157|Archaea,41S7X@651137|Thaumarchaeota 651137|Thaumarchaeota O Cell division protein 48 (CDC48) domain 2 - - - ko:K13525 ko04141,ko05134,map04141,map05134 M00400,M00403 - - ko00000,ko00001,ko00002,ko03019,ko04131,ko04147 3.A.16.1 - - AAA,CDC48_2,CDC48_N k59_181315_1 1437824.BN940_14271 3.36e-65 211.0 COG0183@1|root,COG0183@2|Bacteria,1MU8C@1224|Proteobacteria,2VZC0@28216|Betaproteobacteria,3T2B0@506|Alcaligenaceae 28216|Betaproteobacteria I Thiolase, C-terminal domain - - 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N k59_181315_2 93220.LV28_11840 1.18e-07 54.7 COG1028@1|root,COG1028@2|Bacteria,1MU5Y@1224|Proteobacteria,2VIKT@28216|Betaproteobacteria,1K1GE@119060|Burkholderiaceae 28216|Betaproteobacteria IQ Belongs to the short-chain dehydrogenases reductases (SDR) family bdhA GO:0000003,GO:0000166,GO:0001568,GO:0001676,GO:0001944,GO:0003674,GO:0003824,GO:0004888,GO:0004930,GO:0004953,GO:0004954,GO:0004955,GO:0004957,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0006636,GO:0006690,GO:0006692,GO:0006693,GO:0007154,GO:0007165,GO:0007166,GO:0007167,GO:0007178,GO:0007179,GO:0007186,GO:0007275,GO:0007276,GO:0007292,GO:0007565,GO:0007567,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009653,GO:0009719,GO:0009987,GO:0010033,GO:0016053,GO:0016404,GO:0016491,GO:0016614,GO:0016616,GO:0019372,GO:0019752,GO:0019953,GO:0022414,GO:0023052,GO:0030728,GO:0031974,GO:0031981,GO:0032501,GO:0032502,GO:0032504,GO:0032787,GO:0033559,GO:0035239,GO:0035295,GO:0036094,GO:0038023,GO:0042221,GO:0042759,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044428,GO:0044444,GO:0044446,GO:0044464,GO:0044703,GO:0044706,GO:0045786,GO:0046394,GO:0046456,GO:0046983,GO:0048037,GO:0048514,GO:0048519,GO:0048523,GO:0048609,GO:0048731,GO:0048844,GO:0048856,GO:0050662,GO:0050789,GO:0050794,GO:0050896,GO:0051287,GO:0051704,GO:0051716,GO:0051726,GO:0055114,GO:0060089,GO:0060840,GO:0065007,GO:0070013,GO:0070403,GO:0070493,GO:0070848,GO:0070887,GO:0071310,GO:0071363,GO:0071495,GO:0071559,GO:0071560,GO:0071704,GO:0072330,GO:0072358,GO:0072359,GO:0097070,GO:0097159,GO:1901265,GO:1901363,GO:1901568,GO:1901570,GO:1901576,GO:2001300,GO:2001301 1.1.1.30 ko:K00019 ko00072,ko00650,ko01100,map00072,map00650,map01100 M00088 R01361 RC00117 ko00000,ko00001,ko00002,ko01000 - - - adh_short,adh_short_C2 k59_1084884_2 1254432.SCE1572_46000 4.75e-40 135.0 COG1145@1|root,COG1145@2|Bacteria,1MZ6H@1224|Proteobacteria,42U8W@68525|delta/epsilon subdivisions,2X3DV@28221|Deltaproteobacteria,2YVMF@29|Myxococcales 28221|Deltaproteobacteria C 4Fe-4S binding domain - - - - - - - - - - - - Fer4,Fer4_7 k59_1198097_1 1056820.KB900656_gene3626 4.73e-66 213.0 COG3119@1|root,COG3119@2|Bacteria,1N6NX@1224|Proteobacteria,1RPWH@1236|Gammaproteobacteria,2PP8E@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria P Protein of unknown function (DUF1552) - - - - - - - - - - - - HXXSHH k59_407244_1 404589.Anae109_2221 4.38e-174 530.0 COG0085@1|root,COG0085@2|Bacteria,1MUC4@1224|Proteobacteria,43DMZ@68525|delta/epsilon subdivisions,2WIW5@28221|Deltaproteobacteria,2YUEA@29|Myxococcales 28221|Deltaproteobacteria K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoB GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234 2.7.7.6 ko:K03043 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7 k59_577508_1 298386.PBPRA1867 4.93e-10 63.2 2E51T@1|root,32ZV5@2|Bacteria,1N9DP@1224|Proteobacteria,1SCTE@1236|Gammaproteobacteria,1Y32H@135623|Vibrionales 135623|Vibrionales S Protein of unknown function (DUF3305) SO4504 - - - - - - - - - - - DUF3305 k59_1369050_1 1336233.JAEH01000007_gene2484 2e-57 186.0 COG0283@1|root,COG0283@2|Bacteria,1MUUD@1224|Proteobacteria,1RNKT@1236|Gammaproteobacteria,2Q8RS@267890|Shewanellaceae 1236|Gammaproteobacteria F Belongs to the cytidylate kinase family. Type 1 subfamily cmk GO:0003674,GO:0003824,GO:0004127,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006573,GO:0006575,GO:0006725,GO:0006732,GO:0006753,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009117,GO:0009123,GO:0009165,GO:0009314,GO:0009628,GO:0009987,GO:0010165,GO:0010212,GO:0015939,GO:0015940,GO:0015949,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0034654,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046939,GO:0046940,GO:0050145,GO:0050896,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.7.4.25 ko:K00945 ko00240,ko01100,map00240,map01100 M00052 R00158,R00512,R01665 RC00002 ko00000,ko00001,ko00002,ko01000 - - iPC815.YPO1391,iSDY_1059.SDY_2348 Cytidylate_kin k59_972231_1 1229909.NSED_09745 8.27e-159 456.0 COG3263@1|root,arCOG01962@2157|Archaea,41SV3@651137|Thaumarchaeota 651137|Thaumarchaeota P Sodium hydrogen exchanger - - - ko:K11105 - - - - ko00000,ko02000 2.A.36.6 - - Na_H_Exchanger k59_916404_1 351348.Maqu_3450 6.43e-161 469.0 COG0138@1|root,COG0138@2|Bacteria,1MUDQ@1224|Proteobacteria,1RMWS@1236|Gammaproteobacteria,4646Q@72275|Alteromonadaceae 1236|Gammaproteobacteria F COG0138 AICAR transformylase IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful) purH GO:0003674,GO:0003824,GO:0004643,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016741,GO:0016742,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.2.3,3.5.4.10 ko:K00602 ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523 M00048 R01127,R04560 RC00026,RC00263,RC00456 ko00000,ko00001,ko00002,ko01000,ko04147 - - iEcHS_1320.EcHS_A4240,iPC815.YPO3728 AICARFT_IMPCHas,MGS k59_1594384_1 107635.AZUO01000001_gene3168 3.01e-144 427.0 COG3604@1|root,COG3604@2|Bacteria,1QTT3@1224|Proteobacteria,2TW04@28211|Alphaproteobacteria,36XZN@31993|Methylocystaceae 28211|Alphaproteobacteria KT GAF domain nifA - - ko:K02584 ko02020,map02020 - - - ko00000,ko00001,ko03000 - - - GAF,HTH_8,Sigma54_activat k59_1142250_1 930169.B5T_01228 1.6e-33 127.0 COG5285@1|root,COG5285@2|Bacteria,1PF68@1224|Proteobacteria,1RYF8@1236|Gammaproteobacteria,1XPMF@135619|Oceanospirillales 135619|Oceanospirillales Q Phytanoyl-CoA dioxygenase (PhyH) - - - - - - - - - - - - PhyH k59_182197_1 1178825.ALIH01000003_gene2231 1.26e-107 331.0 COG0366@1|root,COG0366@2|Bacteria,4NFMM@976|Bacteroidetes,1HZ0S@117743|Flavobacteriia 976|Bacteroidetes G Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB glgE - 2.4.99.16 ko:K16147 ko00500,ko01100,map00500,map01100 - R09994 - ko00000,ko00001,ko01000 - GH13 - Alpha-amylase,DUF3416 k59_1707052_1 1509405.GV67_18875 1.86e-44 159.0 COG3659@1|root,COG3659@2|Bacteria,1QIBX@1224|Proteobacteria,2VFW6@28211|Alphaproteobacteria 28211|Alphaproteobacteria M Carbohydrate-selective porin, OprB family - - - - - - - - - - - - OprB k59_916417_1 1380600.AUYN01000003_gene231 3.37e-38 146.0 COG1345@1|root,COG1361@1|root,COG1345@2|Bacteria,COG1361@2|Bacteria 2|Bacteria M extracellular matrix structural constituent - - - - - - - - - - - - CHU_C,DUF11,HYR,Laminin_G_3,SprB k59_1763904_1 247633.GP2143_17656 1.39e-29 113.0 2CDAN@1|root,3134Z@2|Bacteria,1N8A0@1224|Proteobacteria,1T67A@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Gluconate 2-dehydrogenase subunit 3 - - - - - - - - - - - - Gluconate_2-dh3 k59_1763904_2 247633.GP2143_17661 1.02e-197 563.0 COG2303@1|root,COG2303@2|Bacteria,1MU3F@1224|Proteobacteria,1RPBQ@1236|Gammaproteobacteria,1J5ZV@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E COG2303 Choline dehydrogenase and related flavoproteins neoG - - - - - - - - - - - FAD_binding_2,GMC_oxred_C,GMC_oxred_N,NAD_binding_8 k59_633926_1 426355.Mrad2831_2592 1.83e-131 407.0 COG5013@1|root,COG5013@2|Bacteria,1MW9S@1224|Proteobacteria,2TQJW@28211|Alphaproteobacteria,1JTXZ@119045|Methylobacteriaceae 28211|Alphaproteobacteria C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family narZ - 1.7.5.1 ko:K00370 ko00910,ko01120,ko02020,map00910,map01120,map02020 M00529,M00530,M00804 R00798,R01106,R09497 RC02812 ko00000,ko00001,ko00002,ko01000 5.A.3.1 - - Molybdopterin,Molydop_binding,Nitr_red_alph_N k59_746650_1 502025.Hoch_4833 3.6e-95 291.0 COG4664@1|root,COG4664@2|Bacteria,1R4MZ@1224|Proteobacteria,42YBQ@68525|delta/epsilon subdivisions,2WTKK@28221|Deltaproteobacteria,2Z06Q@29|Myxococcales 28221|Deltaproteobacteria Q PFAM TRAP C4-dicarboxylate transport system permease DctM subunit - - - - - - - - - - - - DctM k59_746650_2 1033802.SSPSH_001986 1.65e-09 58.2 COG4665@1|root,COG4665@2|Bacteria,1RHBW@1224|Proteobacteria,1S5Y0@1236|Gammaproteobacteria 1236|Gammaproteobacteria Q TRAP-type mannitol chloroaromatic compound transport system small permease component - - - - - - - - - - - - DctQ k59_464453_1 288705.RSal33209_0002 3.35e-36 138.0 COG0592@1|root,COG0592@2|Bacteria,2GJK3@201174|Actinobacteria,1W83N@1268|Micrococcaceae 201174|Actinobacteria L Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria dnaN GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 2.7.7.7 ko:K02338 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_beta,DNA_pol3_beta_2,DNA_pol3_beta_3 k59_972292_2 926560.KE387023_gene3172 1.01e-19 92.8 COG5146@1|root,COG5146@2|Bacteria 2|Bacteria H pantothenate kinase activity coaW - 2.7.1.33 ko:K09680 ko00770,ko01100,map00770,map01100 M00120 R02971,R03018,R04391 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - Fumble k59_1085700_1 314265.R2601_23031 1.45e-33 118.0 2E4JF@1|root,32ZEH@2|Bacteria,1NEUM@1224|Proteobacteria,2UF7A@28211|Alphaproteobacteria 28211|Alphaproteobacteria S MazG nucleotide pyrophosphohydrolase domain - - - - - - - - - - - - MazG,MazG-like k59_1431513_2 702113.PP1Y_AT8551 1.71e-81 241.0 COG0537@1|root,COG0537@2|Bacteria,1RDCJ@1224|Proteobacteria,2U956@28211|Alphaproteobacteria,2K4G2@204457|Sphingomonadales 204457|Sphingomonadales FG COG0537 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases - - - - - - - - - - - - HIT k59_19694_1 1279017.AQYJ01000025_gene530 1.56e-59 197.0 COG0845@1|root,COG0845@2|Bacteria,1MU78@1224|Proteobacteria,1RPI1@1236|Gammaproteobacteria,464YI@72275|Alteromonadaceae 1236|Gammaproteobacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family acrA - - ko:K03585 ko01501,ko01503,map01501,map01503 M00646,M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000,ko03036 2.A.6.2,8.A.1.6 - - HlyD,HlyD_D23 k59_1262001_1 1134474.O59_001319 5.02e-40 145.0 COG0607@1|root,COG0664@1|root,COG0607@2|Bacteria,COG0664@2|Bacteria,1R59Q@1224|Proteobacteria,1RSPW@1236|Gammaproteobacteria,1FGBM@10|Cellvibrio 1236|Gammaproteobacteria PT Cyclic nucleotide-monophosphate binding domain - - - - - - - - - - - - Rhodanese,cNMP_binding k59_867839_2 1121405.dsmv_3794 1.08e-30 110.0 COG2161@1|root,COG2161@2|Bacteria,1Q1KR@1224|Proteobacteria,42UB2@68525|delta/epsilon subdivisions,2WQM4@28221|Deltaproteobacteria,2MKMX@213118|Desulfobacterales 28221|Deltaproteobacteria D Antitoxin Phd_YefM, type II toxin-antitoxin system - - - - - - - - - - - - PhdYeFM_antitox k59_1658512_1 455436.DS989814_gene808 2.42e-63 196.0 COG0103@1|root,COG0103@2|Bacteria,1RD4A@1224|Proteobacteria,1S3Q7@1236|Gammaproteobacteria,466SE@72275|Alteromonadaceae 1236|Gammaproteobacteria J Belongs to the universal ribosomal protein uS9 family rpsI GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02996 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S9 k59_1431528_1 448385.sce5444 2.29e-31 128.0 COG0515@1|root,COG0642@1|root,COG2203@1|root,COG3899@1|root,COG0515@2|Bacteria,COG2203@2|Bacteria,COG2205@2|Bacteria,COG3899@2|Bacteria,1NRP8@1224|Proteobacteria,43CV1@68525|delta/epsilon subdivisions,2X82T@28221|Deltaproteobacteria,2Z3JT@29|Myxococcales 28221|Deltaproteobacteria KLT Family membership - - - - - - - - - - - - AAA_16,GAF,GAF_2,HATPase_c,HisKA,PAS_4,Pkinase k59_1545209_1 1122137.AQXF01000002_gene425 1.03e-145 431.0 COG1629@1|root,COG4771@2|Bacteria,1MWKN@1224|Proteobacteria,2TTFY@28211|Alphaproteobacteria 28211|Alphaproteobacteria P receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_19715_1 861299.J421_5971 4.32e-25 108.0 COG2091@1|root,COG2091@2|Bacteria 2|Bacteria H lysine biosynthetic process via aminoadipic acid - - - - - - - - - - - - CBM9_1 k59_1601398_1 316407.4062648 3.97e-171 489.0 COG0728@1|root,COG0728@2|Bacteria,1MUH0@1224|Proteobacteria,1RMXX@1236|Gammaproteobacteria,3XMDX@561|Escherichia 1236|Gammaproteobacteria S Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane murJ GO:0000270,GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0006810,GO:0006869,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0010876,GO:0015647,GO:0015648,GO:0015835,GO:0015836,GO:0016020,GO:0016021,GO:0016043,GO:0022857,GO:0022884,GO:0030203,GO:0031224,GO:0031226,GO:0033036,GO:0034203,GO:0034204,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044425,GO:0044459,GO:0044464,GO:0046836,GO:0051179,GO:0051234,GO:0055085,GO:0061024,GO:0065007,GO:0065008,GO:0070589,GO:0071554,GO:0071702,GO:0071704,GO:0071705,GO:0071840,GO:0071944,GO:0097035,GO:1901135,GO:1901137,GO:1901264,GO:1901505,GO:1901564,GO:1901566,GO:1901576 - ko:K03980 - - - - ko00000,ko01011,ko02000 2.A.66.4 - iECO103_1326.ECO103_1114 MVIN k59_1601399_1 1122137.AQXF01000005_gene1287 2.81e-102 303.0 COG3741@1|root,COG3741@2|Bacteria,1MY4D@1224|Proteobacteria,2TSC3@28211|Alphaproteobacteria 28211|Alphaproteobacteria E N-formylglutamate amidohydrolase hutG - 3.5.1.68,3.5.3.8 ko:K01458,ko:K01479 ko00340,ko00630,ko01100,map00340,map00630,map01100 M00045 R00525,R02285 RC00165,RC00221,RC00323,RC00681 ko00000,ko00001,ko00002,ko01000 - - - FGase k59_19735_1 876044.IMCC3088_1390 8.27e-86 277.0 COG0653@1|root,COG0653@2|Bacteria,1MUJZ@1224|Proteobacteria,1RM9M@1236|Gammaproteobacteria,1J56C@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane secA GO:0000166,GO:0002790,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006457,GO:0006605,GO:0006810,GO:0006886,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0009306,GO:0009987,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032940,GO:0032991,GO:0033036,GO:0033220,GO:0034613,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042802,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0046903,GO:0046907,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0061077,GO:0065002,GO:0070727,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680 - ko:K03070 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4 - - SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW k59_1092710_1 316407.85677142 2.15e-121 348.0 COG0565@1|root,COG0565@2|Bacteria,1MUKP@1224|Proteobacteria,1RMZX@1236|Gammaproteobacteria,3XMAY@561|Escherichia 1236|Gammaproteobacteria J Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA lasT GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - ko:K02533 - - - - ko00000,ko01000,ko03016 - - - SpoU_methylase k59_1376006_1 641107.CDLVIII_0709 9.58e-63 216.0 COG1020@1|root,COG1020@2|Bacteria,1TPTH@1239|Firmicutes,2490U@186801|Clostridia,36EG3@31979|Clostridiaceae 186801|Clostridia Q TIGRFAM amino acid adenylation domain - - - - - - - - - - - - AMP-binding,AMP-binding_C,Condensation,NAD_binding_4,PP-binding,Thioesterase k59_1601425_1 1112214.AHIS01000126_gene3045 4.13e-20 92.0 COG0477@1|root,COG2814@2|Bacteria,1MVQQ@1224|Proteobacteria,2TRBF@28211|Alphaproteobacteria,2K261@204457|Sphingomonadales 204457|Sphingomonadales EGP Major Facilitator - - - - - - - - - - - - MFS_1,MFS_4,TRI12 k59_245269_1 1265313.HRUBRA_02356 1.53e-79 258.0 COG2274@1|root,COG2274@2|Bacteria,1R2T0@1224|Proteobacteria,1SBE1@1236|Gammaproteobacteria,1J5FP@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria V COG2274 ABC-type bacteriocin lantibiotic exporters, contain an N-terminal double-glycine peptidase domain - - - ko:K12541 ko02010,map02010 M00330 - - ko00000,ko00001,ko00002,ko02000,ko02044 3.A.1.109.3,3.A.1.109.4 - - ABC_membrane,ABC_tran,Peptidase_C39 k59_753786_1 1121035.AUCH01000008_gene999 2.64e-69 224.0 COG0168@1|root,COG0168@2|Bacteria,1MUIJ@1224|Proteobacteria,2VH82@28216|Betaproteobacteria,2KUF7@206389|Rhodocyclales 206389|Rhodocyclales P Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA - - - ko:K03498 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - - TrkH k59_1262037_1 1227454.C446_14544 9.15e-07 52.8 COG1945@1|root,arCOG04490@2157|Archaea,2XVMN@28890|Euryarchaeota,23V99@183963|Halobacteria 183963|Halobacteria E Pyruvoyl-dependent arginine decarboxylase pdaD - 4.1.1.19 ko:K02626 ko00330,ko01100,map00330,map01100 M00133 R00566 RC00299 ko00000,ko00001,ko00002,ko01000 - - - PvlArgDC k59_1601429_1 264951.V5GAB4 1.12e-08 61.2 COG1012@1|root,KOG2451@2759|Eukaryota,3AIFC@33154|Opisthokonta,3P05T@4751|Fungi,3RKT3@4890|Ascomycota,20DGD@147545|Eurotiomycetes,3S31K@5042|Eurotiales 4751|Fungi C Dehydrogenase - - - - - - - - - - - - Aldedh k59_1205965_2 1158150.KB906246_gene1923 2.35e-46 152.0 COG2329@1|root,COG2329@2|Bacteria,1RJMH@1224|Proteobacteria,1SAYM@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Antibiotic biosynthesis monooxygenase - - - - - - - - - - - - ABM k59_1376013_1 316407.85674900 1.15e-20 89.0 COG1063@1|root,COG1063@2|Bacteria,1QV3S@1224|Proteobacteria,1RRI1@1236|Gammaproteobacteria,3XPGB@561|Escherichia 1236|Gammaproteobacteria E oxidoreductase activity ycjQ - - - - - - - - - - - ADH_N,ADH_zinc_N,GFO_IDH_MocA,GFO_IDH_MocA_C k59_1376013_2 316407.1742150 6.54e-97 287.0 COG0395@1|root,COG0395@2|Bacteria,1N4I0@1224|Proteobacteria,1SYM3@1236|Gammaproteobacteria,3XNBN@561|Escherichia 1236|Gammaproteobacteria P ABC transporter permease protein YcjP ycjP GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K02026 - M00207 - - ko00000,ko00002,ko02000 3.A.1.1 - - BPD_transp_1 k59_302704_1 1453501.JELR01000002_gene677 3.16e-81 247.0 COG0207@1|root,COG0207@2|Bacteria,1MUBD@1224|Proteobacteria,1RPYV@1236|Gammaproteobacteria,464KC@72275|Alteromonadaceae 1236|Gammaproteobacteria F Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis thyA - 2.1.1.45 ko:K00560 ko00240,ko00670,ko01100,ko01523,map00240,map00670,map01100,map01523 M00053 R02101 RC00219,RC00332 ko00000,ko00001,ko00002,ko01000 - - - Thymidylat_synt k59_77128_1 1396418.BATQ01000058_gene144 8.15e-07 49.3 COG0106@1|root,COG0106@2|Bacteria,46U39@74201|Verrucomicrobia,2ITHN@203494|Verrucomicrobiae 203494|Verrucomicrobiae E Histidine biosynthesis protein - - 5.3.1.16 ko:K01814 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04640 RC00945 ko00000,ko00001,ko00002,ko01000 - - - His_biosynth k59_1149162_1 1089552.KI911559_gene2675 3.94e-59 199.0 2BVRA@1|root,2Z7NJ@2|Bacteria,1R4F2@1224|Proteobacteria,2U0VD@28211|Alphaproteobacteria,2JUG6@204441|Rhodospirillales 204441|Rhodospirillales - - - - - - - - - - - - - - - k59_1545268_1 1151122.AQYD01000007_gene797 1.63e-33 118.0 2E5NA@1|root,330D3@2|Bacteria,2IQ91@201174|Actinobacteria 201174|Actinobacteria S Domain of unknown function (DUF4287) - - - - - - - - - - - - DUF4287 k59_245280_1 1500259.JQLD01000019_gene4592 2.64e-06 55.8 COG4676@1|root,COG4676@2|Bacteria,1NDGH@1224|Proteobacteria 1224|Proteobacteria S Protein conserved in bacteria - - - - - - - - - - - - - k59_19760_1 211586.SO_1351 5.71e-99 295.0 COG0854@1|root,COG0854@2|Bacteria,1MU9W@1224|Proteobacteria,1RMS5@1236|Gammaproteobacteria,2Q9IK@267890|Shewanellaceae 1236|Gammaproteobacteria H Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate pdxJ GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008614,GO:0008615,GO:0009058,GO:0009110,GO:0009987,GO:0016740,GO:0016769,GO:0017144,GO:0018130,GO:0019438,GO:0033856,GO:0034641,GO:0042364,GO:0042802,GO:0042816,GO:0042819,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072524,GO:0072525,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 2.6.99.2 ko:K03474 ko00750,ko01100,map00750,map01100 M00124 R05838 RC01476 ko00000,ko00001,ko00002,ko01000 - - iAF1260.b2564,iB21_1397.B21_02422,iBWG_1329.BWG_2328,iEC55989_1330.EC55989_2852,iECBD_1354.ECBD_1117,iECB_1328.ECB_02458,iECDH10B_1368.ECDH10B_2732,iECDH1ME8569_1439.ECDH1ME8569_2491,iECD_1391.ECD_02458,iECH74115_1262.ECH74115_3800,iECIAI1_1343.ECIAI1_2675,iECO103_1326.ECO103_3142,iECO111_1330.ECO111_3290,iECO26_1355.ECO26_3611,iECSE_1348.ECSE_2852,iECSP_1301.ECSP_3509,iECW_1372.ECW_m2792,iECs_1301.ECs3430,iEKO11_1354.EKO11_1169,iEcDH1_1363.EcDH1_1104,iEcE24377_1341.EcE24377A_2850,iEcHS_1320.EcHS_A2719,iEcolC_1368.EcolC_1113,iG2583_1286.G2583_3145,iJO1366.b2564,iJR904.b2564,iWFL_1372.ECW_m2792,iY75_1357.Y75_RS13390 PdxJ k59_640966_1 666684.AfiDRAFT_2132 5.36e-20 88.6 COG1509@1|root,COG1509@2|Bacteria,1MUPJ@1224|Proteobacteria,2TT31@28211|Alphaproteobacteria,3JQS7@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria E Lysine-2,3-aminomutase kamA - 5.4.3.2 ko:K01843 ko00310,map00310 - R00461 RC00303 ko00000,ko00001,ko01000 - - - Fer4_12,Fer4_14,LAM_C,Radical_SAM k59_1715193_1 1229909.NSED_00220 5.21e-106 310.0 COG0090@1|root,arCOG04067@2157|Archaea,41SCT@651137|Thaumarchaeota 651137|Thaumarchaeota J One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity rpl2 - - ko:K02886 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L2,Ribosomal_L2_C k59_303648_1 1122612.AUBA01000015_gene880 7.96e-71 222.0 COG0625@1|root,COG0625@2|Bacteria,1R6UY@1224|Proteobacteria,2U1WS@28211|Alphaproteobacteria 28211|Alphaproteobacteria O Glutathione S-transferase, C-terminal domain - - 2.5.1.18 ko:K00799 ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418 - R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905 RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944 ko00000,ko00001,ko01000,ko02000 1.A.12.2.2,1.A.12.3.2 - - GST_C,GST_C_2,GST_N,GST_N_3 k59_303648_2 279238.Saro_0703 3.51e-94 284.0 COG4221@1|root,COG4221@2|Bacteria,1QTXD@1224|Proteobacteria,2TW4Q@28211|Alphaproteobacteria,2K9UY@204457|Sphingomonadales 204457|Sphingomonadales S KR domain - - - - - - - - - - - - adh_short k59_868843_2 1268635.Loa_02080 1.25e-23 101.0 COG0399@1|root,COG0399@2|Bacteria,1MUPN@1224|Proteobacteria,1RNEQ@1236|Gammaproteobacteria,1JCT8@118969|Legionellales 118969|Legionellales E DegT/DnrJ/EryC1/StrS aminotransferase family - - 2.6.1.59 ko:K02805 - - - - ko00000,ko01000,ko01007 - - - DegT_DnrJ_EryC1 k59_415658_1 1380394.JADL01000001_gene2982 1.64e-19 85.1 COG0410@1|root,COG0410@2|Bacteria,1MVVC@1224|Proteobacteria,2TSA6@28211|Alphaproteobacteria,2JZAW@204441|Rhodospirillales 204441|Rhodospirillales E ATPases associated with a variety of cellular activities - - - - - - - - - - - - ABC_tran k59_415658_2 331869.BAL199_24469 1.58e-68 215.0 COG0411@1|root,COG0411@2|Bacteria,1R7BP@1224|Proteobacteria,2U3BF@28211|Alphaproteobacteria,4BS0A@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria E ATPases associated with a variety of cellular activities - - - ko:K01995 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - ABC_tran k59_360238_1 765912.Thimo_1436 5.81e-130 419.0 COG0236@1|root,COG1028@1|root,COG2070@1|root,COG3321@1|root,COG0236@2|Bacteria,COG1028@2|Bacteria,COG2070@2|Bacteria,COG3321@2|Bacteria,1R89Z@1224|Proteobacteria,1SMTI@1236|Gammaproteobacteria,1WXNA@135613|Chromatiales 135613|Chromatiales IQ Beta-ketoacyl synthase - - - - - - - - - - - - Acyl_transf_1,KAsynt_C_assoc,KR,Ketoacyl-synt_C,NMO,PP-binding,ketoacyl-synt k59_20712_1 1121035.AUCH01000015_gene2505 3.25e-58 201.0 COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,2VHQ1@28216|Betaproteobacteria,2KURM@206389|Rhodocyclales 206389|Rhodocyclales NU Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB - - - - - - - - - - - - GAF,T2SSE,T2SSE_N k59_1150095_1 83406.HDN1F_28330 3.2e-15 80.1 COG0763@1|root,COG0763@2|Bacteria,1MVBI@1224|Proteobacteria,1RNS1@1236|Gammaproteobacteria,1J4YZ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell lpxB GO:0003674,GO:0003824,GO:0005488,GO:0005543,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008194,GO:0008289,GO:0008610,GO:0008654,GO:0008915,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0019637,GO:0019897,GO:0019898,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0046467,GO:0046493,GO:0071704,GO:0071944,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 2.4.1.182 ko:K00748 ko00540,ko01100,map00540,map01100 M00060 R04606 RC00005,RC00059 ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT19 iE2348C_1286.E2348C_0187,iEcolC_1368.EcolC_3478 LpxB k59_1038552_1 436308.Nmar_1755 1.64e-93 278.0 COG0592@1|root,arCOG00488@2157|Archaea,41S6E@651137|Thaumarchaeota 651137|Thaumarchaeota L Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication pcn - - ko:K04802 ko03030,ko03410,ko03420,ko03430,ko04110,ko04530,ko05161,ko05166,map03030,map03410,map03420,map03430,map04110,map04530,map05161,map05166 M00295 - - ko00000,ko00001,ko00002,ko03032,ko03400 - - - PCNA_C,PCNA_N k59_1602452_2 1545915.JROG01000004_gene2157 8.37e-26 99.0 COG5470@1|root,COG5470@2|Bacteria,1N8V0@1224|Proteobacteria,2UH45@28211|Alphaproteobacteria,2K737@204457|Sphingomonadales 204457|Sphingomonadales S Domain of unknown function (DUF1330) - - - - - - - - - - - - DUF1330 k59_585274_1 1036674.A28LD_1923 7.02e-61 197.0 COG3267@1|root,COG3267@2|Bacteria,1MU3G@1224|Proteobacteria,1RMI0@1236|Gammaproteobacteria,2QFTV@267893|Idiomarinaceae 1236|Gammaproteobacteria U Uncharacterized conserved protein (DUF2075) mshM - - ko:K12283 - - - - ko00000,ko02044 - - - AAA_22 k59_527886_1 1380394.JADL01000002_gene1632 4.45e-88 266.0 COG0834@1|root,COG0834@2|Bacteria,1N2RR@1224|Proteobacteria,2U0AF@28211|Alphaproteobacteria,2JW71@204441|Rhodospirillales 204441|Rhodospirillales ET Bacterial periplasmic substrate-binding proteins - - - - - - - - - - - - SBP_bac_3 k59_1490051_1 617140.AJZE01000093_gene2446 1.54e-35 133.0 2BIBD@1|root,32CH5@2|Bacteria,1QKR4@1224|Proteobacteria,1TIVH@1236|Gammaproteobacteria,1XZS8@135623|Vibrionales 135623|Vibrionales - - - - - - - - - - - - - - - k59_1093499_1 1380393.JHVP01000001_gene2285 1.77e-12 66.2 COG1228@1|root,COG1228@2|Bacteria,2IE2S@201174|Actinobacteria 201174|Actinobacteria Q Amidohydrolase family - - - - - - - - - - - - Amidohydro_1 k59_1093499_2 317619.ANKN01000155_gene2787 9.26e-33 136.0 COG0659@1|root,COG0664@1|root,COG0659@2|Bacteria,COG0664@2|Bacteria,1G3AY@1117|Cyanobacteria 1117|Cyanobacteria P COGs COG0659 Sulfate permease and related transporter (MFS superfamily) - - - ko:K03321 - - - - ko00000,ko02000 2.A.53.3 - - STAS,Sulfate_transp,cNMP_binding k59_811614_1 1287116.X734_11820 1.8e-27 108.0 COG1220@1|root,COG1220@2|Bacteria,1MVK9@1224|Proteobacteria,2TRXC@28211|Alphaproteobacteria,43GVB@69277|Phyllobacteriaceae 28211|Alphaproteobacteria O this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis hslU - - ko:K03667 - - - - ko00000,ko03110 - - - AAA_2,ClpB_D2-small k59_811614_2 1122137.AQXF01000001_gene3349 1.16e-102 300.0 COG5405@1|root,COG5405@2|Bacteria,1MVF2@1224|Proteobacteria,2TRRE@28211|Alphaproteobacteria 28211|Alphaproteobacteria O Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery hslV - 3.4.25.2 ko:K01419 - - - - ko00000,ko01000,ko01002 - - - Proteasome k59_698432_1 1229909.NSED_03605 2.17e-157 447.0 COG0460@1|root,arCOG01351@2157|Archaea,41SAC@651137|Thaumarchaeota 651137|Thaumarchaeota E homoserine dehydrogenase - - 1.1.1.3 ko:K00003 ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230 M00017,M00018 R01773,R01775 RC00087 ko00000,ko00001,ko00002,ko01000 - - - Homoserine_dh,NAD_binding_3 k59_1038571_1 338963.Pcar_0596 1.74e-07 55.1 COG2239@1|root,COG2239@2|Bacteria,1MW24@1224|Proteobacteria,42MA7@68525|delta/epsilon subdivisions,2WIPC@28221|Deltaproteobacteria,43S0N@69541|Desulfuromonadales 28221|Deltaproteobacteria P Divalent cation transporter - - - ko:K06213 - - - - ko00000,ko02000 1.A.26.1 - - CBS,MgtE,MgtE_N k59_1376984_1 379066.GAU_2716 1.03e-31 120.0 COG1051@1|root,COG1051@2|Bacteria,1ZU0E@142182|Gemmatimonadetes 142182|Gemmatimonadetes F NUDIX domain - - - - - - - - - - - - NUDIX k59_1432296_1 744980.TRICHSKD4_3722 7.21e-12 63.2 2E6PI@1|root,3319W@2|Bacteria,1RCIK@1224|Proteobacteria,2UFSS@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_1432296_2 158500.BV97_02801 2.04e-59 206.0 COG1629@1|root,COG4206@1|root,COG1629@2|Bacteria,COG4206@2|Bacteria,1MXFM@1224|Proteobacteria,2TWYV@28211|Alphaproteobacteria,2K14T@204457|Sphingomonadales 204457|Sphingomonadales H Outer membrane receptor proteins, mostly Fe transport - - - - - - - - - - - - TonB_dep_Rec k59_641650_1 2340.JV46_25840 5.91e-96 303.0 COG0550@1|root,COG0550@2|Bacteria,1MUFZ@1224|Proteobacteria,1RNZ2@1236|Gammaproteobacteria,1J526@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone topA GO:0003674,GO:0003824,GO:0003916,GO:0003917,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006265,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0016853,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051276,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360 5.99.1.2 ko:K03168 - - - - ko00000,ko01000,ko03032,ko03400 - - - Topo_Zn_Ribbon,Topoisom_bac,Toprim,Toprim_C_rpt,zf-C4_Topoisom k59_1038581_1 1158292.JPOE01000002_gene3673 3.64e-12 71.6 COG3344@1|root,COG3344@2|Bacteria,1MVI1@1224|Proteobacteria,2VMDU@28216|Betaproteobacteria,1KNQW@119065|unclassified Burkholderiales 28216|Betaproteobacteria L Reverse transcriptase (RNA-dependent DNA polymerase) - - - - - - - - - - - - GIIM,RVT_1 k59_979708_1 1306947.ARQD01000001_gene921 1.38e-52 187.0 COG1181@1|root,COG1181@2|Bacteria 2|Bacteria F Belongs to the D-alanine--D-alanine ligase family - - 6.3.2.4 ko:K01921 ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502 - R01150 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - ATP-grasp,ATP-grasp_4,CPSase_L_D2 k59_133676_1 565045.NOR51B_2509 2.35e-98 295.0 COG0604@1|root,COG0604@2|Bacteria,1MV3W@1224|Proteobacteria,1RMHG@1236|Gammaproteobacteria,1J5KW@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C COG0604 NADPH quinone reductase and related Zn-dependent oxidoreductases yhdH - - ko:K19745 ko00640,ko01100,map00640,map01100 - R00919 RC00095 ko00000,ko00001,ko01000 - - - ADH_N,ADH_zinc_N k59_811630_1 316407.85674720 8.4e-136 385.0 COG1475@1|root,COG1475@2|Bacteria,1R5VN@1224|Proteobacteria,1RZ7C@1236|Gammaproteobacteria,3XNY5@561|Escherichia 1236|Gammaproteobacteria K ParB-like nuclease domain ybdM - - - - - - - - - - - ParBc k59_811630_2 316407.4062217 2.09e-77 240.0 COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,1RNN0@1236|Gammaproteobacteria,3XM9Q@561|Escherichia 1236|Gammaproteobacteria E Aminotransferase ybdL GO:0003674,GO:0003824,GO:0005488,GO:0008144,GO:0008483,GO:0010326,GO:0016740,GO:0016769,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0048037,GO:0050662,GO:0070279,GO:0097159,GO:1901363 2.6.1.88 ko:K14287 - - R08618 RC00006,RC00025 ko00000,ko01000,ko01007 - - - Aminotran_1_2 k59_585313_1 857087.Metme_3186 1.39e-73 239.0 COG2918@1|root,COG2918@2|Bacteria,1MW9B@1224|Proteobacteria,1RPNQ@1236|Gammaproteobacteria,1XEMT@135618|Methylococcales 135618|Methylococcales H Belongs to the glutamate--cysteine ligase type 1 family. Type 1 subfamily gshA - 6.3.2.2 ko:K01919 ko00270,ko00480,ko01100,map00270,map00480,map01100 M00118 R00894,R10993 RC00064,RC00090 ko00000,ko00001,ko00002,ko01000 - - - Glu_cys_ligase k59_754524_1 59538.XP_005974543.1 1.25e-21 99.0 COG0531@1|root,KOG1286@2759|Eukaryota,38BM3@33154|Opisthokonta,3BA2V@33208|Metazoa,3CVWA@33213|Bilateria,485T5@7711|Chordata,48VMW@7742|Vertebrata,3JBFK@40674|Mammalia,4IYR9@91561|Cetartiodactyla 33208|Metazoa E cationic amino acid transporter - - - ko:K13866,ko:K13871 - - - - ko00000,ko01009,ko02000 2.A.3.3 - - AA_permease,AA_permease_2,AA_permease_C k59_1490092_1 436308.Nmar_1207 8.75e-42 154.0 COG0642@1|root,arCOG02363@1|root,arCOG02358@2157|Archaea,arCOG02363@2157|Archaea 2157|Archaea T histidine kinase HAMP region domain protein - - 2.7.13.3 ko:K03406,ko:K07709 ko02020,ko02030,map02020,map02030 M00499 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 - - - HAMP,HATPase_c,HisKA,MCPsignal,PAS_9,dCache_1 k59_979722_1 1415778.JQMM01000001_gene2246 2.13e-56 183.0 COG4659@1|root,COG4659@2|Bacteria,1RDEP@1224|Proteobacteria,1RPAD@1236|Gammaproteobacteria,1J6E5@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria U Part of a membrane complex involved in electron transport rnfG - - ko:K03612 - - - - ko00000 - - - FMN_bind k59_1659327_1 983544.Lacal_0135 3.68e-157 474.0 COG0653@1|root,COG0653@2|Bacteria,4NF7C@976|Bacteroidetes,1HXC3@117743|Flavobacteriia 976|Bacteroidetes U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane secA GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680 - ko:K03070 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4 - - Helicase_C,SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW k59_1490098_1 1121012.AUKX01000029_gene944 1.57e-28 110.0 2A450@1|root,30SQ1@2|Bacteria,4PEPS@976|Bacteroidetes,1IF9F@117743|Flavobacteriia,23HQC@178469|Arenibacter 976|Bacteroidetes - - - - - - - - - - - - - - - k59_472079_1 338963.Pcar_2523 1.9e-05 48.9 COG0607@1|root,COG0607@2|Bacteria,1N256@1224|Proteobacteria,42TIJ@68525|delta/epsilon subdivisions,2WQHB@28221|Deltaproteobacteria,43V99@69541|Desulfuromonadales 28221|Deltaproteobacteria P Rhodanese Homology Domain - - - - - - - - - - - - Rhodanese k59_1319977_1 1229909.NSED_07415 4.41e-159 448.0 COG2159@1|root,arCOG01931@2157|Archaea 2157|Archaea S metal-dependent hydrolase of the TIM-barrel fold - - - ko:K07045 - - - - ko00000 - - - Amidohydro_2 k59_246242_1 1250278.JQNQ01000001_gene2 2e-36 141.0 COG0577@1|root,COG0577@2|Bacteria,4NDUK@976|Bacteroidetes,1HX0V@117743|Flavobacteriia 976|Bacteroidetes V COG0577 ABC-type antimicrobial peptide transport system permease component - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_1546358_1 1122137.AQXF01000002_gene338 1.13e-184 522.0 COG0162@1|root,COG0162@2|Bacteria,1MVUQ@1224|Proteobacteria,2TQPA@28211|Alphaproteobacteria 28211|Alphaproteobacteria J Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) tyrS GO:0003674,GO:0003824,GO:0004812,GO:0004831,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016875,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564 6.1.1.1 ko:K01866 ko00970,map00970 M00359,M00360 R02918 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - S4,tRNA-synt_1b k59_1546358_2 1122137.AQXF01000002_gene337 0.000746 41.2 COG2377@1|root,COG2377@2|Bacteria,1MV4E@1224|Proteobacteria,2TS4G@28211|Alphaproteobacteria 28211|Alphaproteobacteria O Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling anmK - 2.7.1.170 ko:K09001 - - - - ko00000,ko01000 - - - AnmK k59_415741_2 1229172.JQFA01000004_gene694 2.08e-49 170.0 COG0719@1|root,COG0719@2|Bacteria,1G0TH@1117|Cyanobacteria,1H8CG@1150|Oscillatoriales 1117|Cyanobacteria O COG0719 ABC-type transport system involved in Fe-S cluster assembly permease component sufB - - ko:K09014 - - - - ko00000 - - - UPF0051 k59_1556973_1 1122137.AQXF01000003_gene2265 1.55e-82 270.0 COG1913@1|root,COG1913@2|Bacteria,1MY52@1224|Proteobacteria,2TUDY@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Domain of unknown function (DUF5117) - - - - - - - - - - - - DUF4953,DUF5117 k59_1777426_1 472759.Nhal_3285 1.2e-39 138.0 COG0560@1|root,COG0560@2|Bacteria,1RA1A@1224|Proteobacteria,1S21J@1236|Gammaproteobacteria,1WXJF@135613|Chromatiales 135613|Chromatiales E HAD-superfamily subfamily IB hydrolase, TIGR01490 - - - - - - - - - - - - HAD k59_255694_1 316407.85676030 1.27e-63 196.0 COG1438@1|root,COG1438@2|Bacteria,1N2AF@1224|Proteobacteria,1RSF7@1236|Gammaproteobacteria,3XN1P@561|Escherichia 1236|Gammaproteobacteria K Regulates arginine biosynthesis genes argR GO:0000820,GO:0000821,GO:0000976,GO:0000984,GO:0000986,GO:0000987,GO:0001017,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006259,GO:0006310,GO:0006355,GO:0006520,GO:0006521,GO:0006525,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009064,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009894,GO:0009987,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010565,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0016043,GO:0016597,GO:0019219,GO:0019222,GO:0019752,GO:0022607,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0031329,GO:0031333,GO:0031334,GO:0031406,GO:0033238,GO:0033241,GO:0034214,GO:0034618,GO:0034641,GO:0036094,GO:0042150,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043177,GO:0043254,GO:0043436,GO:0043565,GO:0043933,GO:0044085,GO:0044087,GO:0044089,GO:0044212,GO:0044237,GO:0044238,GO:0044260,GO:0044281,GO:0044424,GO:0044464,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0046483,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051129,GO:0051130,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0051259,GO:0060255,GO:0062012,GO:0065003,GO:0065007,GO:0071704,GO:0071840,GO:0080090,GO:0090304,GO:0097159,GO:1900079,GO:1900081,GO:1901360,GO:1901363,GO:1901564,GO:1901605,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2000142,GO:2000143,GO:2000144,GO:2000282,GO:2001141 - ko:K03402 - - - - ko00000,ko03000 - - - Arg_repressor,Arg_repressor_C k59_708275_1 1385515.N791_13845 2.69e-75 234.0 COG2086@1|root,COG2086@2|Bacteria,1MVH6@1224|Proteobacteria,1RN6F@1236|Gammaproteobacteria,1X34D@135614|Xanthomonadales 135614|Xanthomonadales C electron transfer flavoprotein beta subunit etfB - - ko:K03521 - - - - ko00000 - - - ETF k59_1500123_1 177439.DP1710 2.43e-49 169.0 COG2006@1|root,COG2006@2|Bacteria,1RABP@1224|Proteobacteria,42QQA@68525|delta/epsilon subdivisions,2WMRX@28221|Deltaproteobacteria,2MK55@213118|Desulfobacterales 28221|Deltaproteobacteria C PFAM 4Fe-4S ferredoxin iron-sulfur binding domain protein - - - - - - - - - - - - DUF362,Fer4 k59_761382_1 1323361.JPOC01000029_gene2299 2.28e-12 67.0 COG0554@1|root,COG0554@2|Bacteria,2GM13@201174|Actinobacteria,4FVX5@85025|Nocardiaceae 201174|Actinobacteria C Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate glpK GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615 2.7.1.30 ko:K00864 ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626 - R00847 RC00002,RC00017 ko00000,ko00001,ko01000,ko04147 - - - FGGY_C,FGGY_N k59_761382_2 871968.DESME_05930 1.18e-27 108.0 COG0558@1|root,COG0558@2|Bacteria,1V6PJ@1239|Firmicutes,24J7Y@186801|Clostridia,261MJ@186807|Peptococcaceae 186801|Clostridia I Belongs to the CDP-alcohol phosphatidyltransferase class-I family pgsA - 2.7.8.5 ko:K00995 ko00564,ko01100,map00564,map01100 - R01801 RC00002,RC00017,RC02795 ko00000,ko00001,ko01000 - - - CDP-OH_P_transf k59_314726_2 553184.ATORI0001_0677 8.31e-50 169.0 COG2255@1|root,COG2255@2|Bacteria,2GJZF@201174|Actinobacteria,4CUPG@84998|Coriobacteriia 84998|Coriobacteriia L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing ruvB - 3.6.4.12 ko:K03551 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - RuvB_C,RuvB_N k59_931993_1 580332.Slit_1527 1.14e-96 290.0 COG0416@1|root,COG0416@2|Bacteria,1MVM3@1224|Proteobacteria,2VI25@28216|Betaproteobacteria,44VJN@713636|Nitrosomonadales 28216|Betaproteobacteria I Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA plsX - 2.3.1.15 ko:K03621 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R00851,R09380 RC00004,RC00039,RC00041 ko00000,ko00001,ko00002,ko01000,ko01004 - - - FA_synthesis k59_931994_1 926569.ANT_10860 4.15e-83 273.0 COG0086@1|root,COG0086@2|Bacteria,2G632@200795|Chloroflexi 200795|Chloroflexi K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoC GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234 2.7.7.6 ko:K03046 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5 k59_1387996_1 760117.JN27_17740 4.14e-39 154.0 COG0642@1|root,COG3300@1|root,COG2205@2|Bacteria,COG3300@2|Bacteria,1NRP8@1224|Proteobacteria,2VGZQ@28216|Betaproteobacteria,475DF@75682|Oxalobacteraceae 28216|Betaproteobacteria T Bacterial signalling protein N terminal repeat - - - - - - - - - - - - CHASE,HAMP,HATPase_c,HisKA,Hpt,MHYT,PAS,PAS_3,PAS_4,PAS_9,Response_reg,dCache_1 k59_879806_1 316407.85676667 5.2e-157 441.0 COG0524@1|root,COG0524@2|Bacteria,1R6C2@1224|Proteobacteria,1RWC9@1236|Gammaproteobacteria,3XQAZ@561|Escherichia 1236|Gammaproteobacteria F Catalyzes the ATP-dependent phosphorylation of fructoselysine to fructoselysine 6-phosphate. Functions in a fructoselysine degradation pathway that allows E.coli to grow on fructoselysine or psicoselysine. To a much lesser extenst, is also able to phosphorylate psicoselysine frlD GO:0003674,GO:0003824,GO:0005975,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0019200,GO:0044237,GO:0044238,GO:0044262,GO:0046835,GO:0071704 2.7.1.218 ko:K10710 - - R08124 RC00002,RC00017 ko00000,ko01000 - - iECs_1301.ECs4224,iETEC_1333.ETEC_3624 PfkB k59_479814_1 391615.ABSJ01000037_gene864 3.83e-31 119.0 COG2370@1|root,COG2370@2|Bacteria,1MV6Z@1224|Proteobacteria,1RNIU@1236|Gammaproteobacteria,1JA9J@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O HupE / UreJ protein - - - - - - - - - - - - HupE_UreJ_2 k59_479814_2 316067.Geob_3118 2.35e-38 147.0 COG0697@1|root,COG2371@1|root,COG0697@2|Bacteria,COG2371@2|Bacteria,1N3FA@1224|Proteobacteria,42RW0@68525|delta/epsilon subdivisions,2WNEH@28221|Deltaproteobacteria 28221|Deltaproteobacteria EG EamA-like transporter family - - - - - - - - - - - - EamA k59_1501181_1 1234364.AMSF01000080_gene3052 3.15e-23 94.4 COG0546@1|root,COG0546@2|Bacteria,1QTZ0@1224|Proteobacteria,1RZWV@1236|Gammaproteobacteria,1X5KH@135614|Xanthomonadales 135614|Xanthomonadales S haloacid dehalogenase-like hydrolase - - - - - - - - - - - - HAD_2 k59_1101899_1 1116472.MGMO_86c00100 8.87e-08 52.8 COG2976@1|root,COG2976@2|Bacteria,1N117@1224|Proteobacteria,1S95P@1236|Gammaproteobacteria,1XF0Z@135618|Methylococcales 135618|Methylococcales S Tetratricopeptide repeat-like domain - - - - - - - - - - - - TPR_21 k59_1101899_2 1121939.L861_19925 4.01e-53 181.0 COG0124@1|root,COG0124@2|Bacteria,1MV2K@1224|Proteobacteria,1RPHI@1236|Gammaproteobacteria,1XIK3@135619|Oceanospirillales 135619|Oceanospirillales J histidyl-tRNA synthetase hisS - 6.1.1.21 ko:K01892 ko00970,map00970 M00359,M00360 R03655 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,tRNA-synt_His k59_1217563_2 1192759.AKIB01000003_gene734 4.16e-48 168.0 COG0391@1|root,COG0391@2|Bacteria,1NK78@1224|Proteobacteria,2TUUA@28211|Alphaproteobacteria,2K3GV@204457|Sphingomonadales 204457|Sphingomonadales S LPPG Fo 2-phospho-L-lactate transferase - - 2.7.8.28 ko:K11212 ko00680,ko01120,map00680,map01120 M00378 R09398 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - UPF0052 k59_143332_1 1042375.AFPL01000038_gene1604 1.43e-49 176.0 COG4666@1|root,COG4666@2|Bacteria,1MUNB@1224|Proteobacteria,1RMH7@1236|Gammaproteobacteria,465DR@72275|Alteromonadaceae 1236|Gammaproteobacteria S transport system, fused permease components - - - - - - - - - - - - DctM k59_932009_1 84531.JMTZ01000006_gene3528 1.33e-91 291.0 COG2885@1|root,COG3808@1|root,COG2885@2|Bacteria,COG3808@2|Bacteria,1MUQ3@1224|Proteobacteria,1RN4K@1236|Gammaproteobacteria,1X3IX@135614|Xanthomonadales 135614|Xanthomonadales C Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force hppA - 3.6.1.1 ko:K15987 ko00190,map00190 - - - ko00000,ko00001,ko01000 3.A.10.1 - - H_PPase k59_31931_1 1265313.HRUBRA_00178 3.07e-24 96.7 COG3245@1|root,COG3245@2|Bacteria,1MZBZ@1224|Proteobacteria,1S9Z9@1236|Gammaproteobacteria 1236|Gammaproteobacteria C cytochrome c5 cyc - 1.9.3.1 ko:K02277 ko00190,ko01100,map00190,map01100 M00155 - - ko00000,ko00001,ko00002,ko01000 3.D.4.4 - - Cytochrome_CBB3 k59_31931_2 394221.Mmar10_0655 1.06e-38 137.0 COG0457@1|root,COG0457@2|Bacteria,1N9D5@1224|Proteobacteria,2UIQ4@28211|Alphaproteobacteria,43YUT@69657|Hyphomonadaceae 28211|Alphaproteobacteria S Tetratricopeptide repeat - - - - - - - - - - - - - k59_256783_1 1120705.FG95_02945 1.4e-52 181.0 COG1228@1|root,COG1228@2|Bacteria,1MVAF@1224|Proteobacteria,2U0BD@28211|Alphaproteobacteria,2KCU9@204457|Sphingomonadales 204457|Sphingomonadales Q Amidohydrolase family - - - - - - - - - - - - Amidohydro_1 k59_932010_1 298654.FraEuI1c_0189 2.64e-90 273.0 28IYZ@1|root,2Z8WJ@2|Bacteria,2HJ6A@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - - k59_1327615_1 314278.NB231_10068 7.27e-100 306.0 COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,1RPWS@1236|Gammaproteobacteria,1WWTW@135613|Chromatiales 135613|Chromatiales S ABC transporter - - - - - - - - - - - - ABC_tran,ABC_tran_Xtn k59_709364_2 36331.EPrPI00000026027 5.3e-08 56.6 COG1028@1|root,KOG1611@2759|Eukaryota,1MAST@121069|Pythiales 121069|Pythiales Q Short chain dehydrogenase. Source PGD - - - - - - - - - - - - adh_short k59_879832_1 1384056.N787_01450 1.86e-34 125.0 COG2717@1|root,COG2717@2|Bacteria,1RDUP@1224|Proteobacteria,1RS9K@1236|Gammaproteobacteria,1X631@135614|Xanthomonadales 135614|Xanthomonadales C Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain msrQ - - ko:K17247 - - - - ko00000 - - - Ferric_reduct k59_932012_1 1229909.NSED_01245 1.25e-148 426.0 arCOG08783@1|root,arCOG08783@2157|Archaea,41SFX@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_31942_1 944435.AXAJ01000020_gene5002 1.55e-22 96.7 COG5000@1|root,COG5000@2|Bacteria,1QWFK@1224|Proteobacteria,2VRZ4@28216|Betaproteobacteria,1K73Q@119060|Burkholderiaceae 28216|Betaproteobacteria T PAS domain - - - - - - - - - - - - PAS k59_879843_2 1229909.NSED_01945 2.99e-119 353.0 COG5253@1|root,arCOG04169@2157|Archaea,41S9X@651137|Thaumarchaeota 651137|Thaumarchaeota U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently secY - - ko:K03076 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5 - - Plug_translocon,SecY k59_762146_1 420324.KI911992_gene7720 2.2e-05 50.1 2F1X1@1|root,33UWM@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_1270883_1 1174528.JH992893_gene5887 3.15e-57 200.0 COG0236@1|root,COG0824@1|root,COG1028@1|root,COG2091@1|root,COG0236@2|Bacteria,COG0824@2|Bacteria,COG1028@2|Bacteria,COG2091@2|Bacteria 2|Bacteria H lysine biosynthetic process via aminoadipic acid pfaA - - ko:K05553,ko:K06133,ko:K07107 ko00253,ko00770,ko01056,ko01130,map00253,map00770,map01056,map01130 M00778 R01625,R06635,R06637,R06641,R06643,R06644,R06645,R09258,R09259,R10960,R11516 RC00002,RC00004,RC00039,RC02545,RC02728,RC02729,RC02931,RC02932,RC02947 ko00000,ko00001,ko00002,ko01000,ko01004,ko01008 - - - 4HBT,ACPS,Acyl_transf_1,KAsynt_C_assoc,KR,Ketoacyl-synt_C,Methyltransf_12,PP-binding,PS-DH,ketoacyl-synt k59_1440333_3 1335230.S5WB65_9CAUD 3.7e-40 158.0 4QD3F@10239|Viruses,4QPXD@28883|Caudovirales,4QJ9P@10662|Myoviridae 10662|Myoviridae - - - - - - - - - - - - - - - k59_596215_1 1129794.C427_1366 3.56e-50 194.0 COG0596@1|root,COG4206@1|root,COG0596@2|Bacteria,COG4206@2|Bacteria,1QVV2@1224|Proteobacteria,1T4JF@1236|Gammaproteobacteria 1236|Gammaproteobacteria H TonB dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_649667_1 436308.Nmar_0006 2.16e-84 251.0 arCOG08807@1|root,arCOG08807@2157|Archaea,41SRC@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_596220_1 382464.ABSI01000006_gene852 2.88e-65 224.0 COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1144@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1144@2|Bacteria 2|Bacteria C oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor preT - 1.2.7.1 ko:K00171,ko:K03737 ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200 M00173,M00307,M00374,M00620 R01196,R01199,R08034,R10866 RC00004,RC00250,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - Fer4,Fer4_20,Fer4_6,PFOR_II,POR,POR_N,Pyr_redox_2,Pyr_redox_3,TPP_enzyme_C k59_819497_1 1096930.L284_06705 3.19e-41 146.0 COG2017@1|root,COG2017@2|Bacteria,1MVMN@1224|Proteobacteria,2TTJ7@28211|Alphaproteobacteria,2K0YY@204457|Sphingomonadales 204457|Sphingomonadales G Converts alpha-aldose to the beta-anomer galM - 5.1.3.3 ko:K01785 ko00010,ko00052,ko01100,ko01110,ko01120,ko01130,map00010,map00052,map01100,map01110,map01120,map01130 M00632 R01602,R10619 RC00563 ko00000,ko00001,ko00002,ko01000 - - - Aldose_epim k59_819497_2 158500.BV97_01240 1.28e-10 61.2 COG0738@1|root,COG0738@2|Bacteria,1MXDC@1224|Proteobacteria,2TSVP@28211|Alphaproteobacteria,2K028@204457|Sphingomonadales 204457|Sphingomonadales G Transporter gluP - - ko:K02429 - - - - ko00000,ko02000 2.A.1.7 - - MFS_1 k59_1159873_1 686340.Metal_2838 1.54e-13 70.1 COG0500@1|root,COG2226@2|Bacteria,1MV4M@1224|Proteobacteria,1RMWY@1236|Gammaproteobacteria,1XEF3@135618|Methylococcales 135618|Methylococcales J Catalyzes the conversion of S-adenosyl-L-methionine (SAM) to carboxy-S-adenosyl-L-methionine (Cx-SAM) cmoA - - ko:K15256 - - - - ko00000,ko01000,ko03016 - - - Methyltransf_25 k59_1159873_2 640081.Dsui_0128 4.54e-23 97.8 COG1686@1|root,COG1686@2|Bacteria,1MWZA@1224|Proteobacteria,2VH1S@28216|Betaproteobacteria,2KUX8@206389|Rhodocyclales 206389|Rhodocyclales M Belongs to the peptidase S11 family pbp - - ko:K07262 - - - - ko00000,ko01000,ko01002,ko01011 - - - Peptidase_S11 k59_762152_1 1056512.D515_01491 2.16e-07 52.0 COG3911@1|root,COG3911@2|Bacteria,1RD7P@1224|Proteobacteria,1S3SW@1236|Gammaproteobacteria,1XUT5@135623|Vibrionales 135623|Vibrionales S AAA domain - - - - - - - - - - - - AAA_28 k59_762152_2 1237149.C900_04468 4.68e-17 80.5 COG0449@1|root,COG0449@2|Bacteria,4NE8Q@976|Bacteroidetes,47KVG@768503|Cytophagia 976|Bacteroidetes M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source glmS GO:0003674,GO:0003824,GO:0004360,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006002,GO:0006040,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009987,GO:0016740,GO:0016769,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0036211,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576 2.6.1.16 ko:K00820 ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931 - R00768 RC00010,RC00163,RC02752 ko00000,ko00001,ko01000,ko01002 - - - GATase_6,SIS k59_1667618_1 1134474.O59_000322 3.41e-28 119.0 28JXB@1|root,2Z9MU@2|Bacteria 2|Bacteria S Outer membrane protein SusF_SusE - - - ko:K21571 - - - - ko00000 - - - SusF_SusE k59_1778134_1 756067.MicvaDRAFT_3583 1.33e-77 272.0 COG0515@1|root,COG0642@1|root,COG2114@1|root,COG3899@1|root,COG0515@2|Bacteria,COG2114@2|Bacteria,COG2205@2|Bacteria,COG3899@2|Bacteria,1GBKM@1117|Cyanobacteria,1H7D9@1150|Oscillatoriales 1117|Cyanobacteria KLT Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - AAA_16,GAF,Guanylate_cyc,HATPase_c,HisKA,PAS_4,Pkinase,Response_reg k59_1725576_1 228410.NE1911 1.64e-13 65.5 COG0278@1|root,COG0278@2|Bacteria,1MZ4V@1224|Proteobacteria,2VSCX@28216|Betaproteobacteria,373DG@32003|Nitrosomonadales 28216|Betaproteobacteria C Belongs to the glutaredoxin family. Monothiol subfamily grxD - - ko:K07390 - - - - ko00000,ko03029,ko03110 - - - Glutaredoxin k59_1725576_2 228410.NE1912 3.17e-77 242.0 COG2890@1|root,COG2890@2|Bacteria,1MXCQ@1224|Proteobacteria,2VP72@28216|Betaproteobacteria,3727Y@32003|Nitrosomonadales 28216|Betaproteobacteria J Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif prmC - 2.1.1.297 ko:K02493 - - R10806 RC00003,RC03279 ko00000,ko01000,ko03012 - - - MTS,Methyltransf_31 k59_1327637_1 1458357.BG58_09895 3.94e-37 136.0 COG1846@1|root,COG1853@1|root,COG1846@2|Bacteria,COG1853@2|Bacteria,1RGYM@1224|Proteobacteria,2VQA1@28216|Betaproteobacteria,1K8G7@119060|Burkholderiaceae 28216|Betaproteobacteria K Flavin reductase like domain - - - ko:K16048 ko00984,ko01100,map00984,map01100 - R09819 RC00236 ko00000,ko00001,ko01000 - - - Flavin_Reduct k59_31971_1 1096930.L284_00805 1.04e-106 324.0 COG0544@1|root,COG0544@2|Bacteria,1MUJP@1224|Proteobacteria,2TS8W@28211|Alphaproteobacteria,2K02U@204457|Sphingomonadales 204457|Sphingomonadales D Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase tig GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - ko:K03545 - - - - ko00000 - - - FKBP_C,Trigger_C,Trigger_N k59_143364_1 318996.AXAZ01000033_gene6446 2.22e-29 115.0 COG0517@1|root,COG0517@2|Bacteria,1MXI6@1224|Proteobacteria,2TS6X@28211|Alphaproteobacteria,3JWIG@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S Putative transposase - - - - - - - - - - - - Y2_Tnp,Zn_Tnp_IS91 k59_1440346_1 1211114.ALIP01000113_gene887 1.16e-124 372.0 COG1874@1|root,COG1874@2|Bacteria,1P0Y5@1224|Proteobacteria,1RZHZ@1236|Gammaproteobacteria,1X4DM@135614|Xanthomonadales 135614|Xanthomonadales G glycoside hydrolase - - - - - - - - - - - - Glyco_hydro_35,Glyco_hydro_42 k59_88971_1 999141.GME_13345 3.28e-65 204.0 COG0088@1|root,COG0088@2|Bacteria,1MXPF@1224|Proteobacteria,1RNNK@1236|Gammaproteobacteria,1XH61@135619|Oceanospirillales 135619|Oceanospirillales J Forms part of the polypeptide exit tunnel rplD - - ko:K02926 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L4 k59_879874_1 767434.Fraau_0422 5.42e-76 241.0 COG2951@1|root,COG3409@1|root,COG2951@2|Bacteria,COG3409@2|Bacteria,1MUZ3@1224|Proteobacteria,1RMQ6@1236|Gammaproteobacteria,1X3YN@135614|Xanthomonadales 135614|Xanthomonadales M Lytic murein transglycosylase - - 5.1.3.15 ko:K01792 ko00010,ko01100,ko01110,ko01120,ko01130,map00010,map01100,map01110,map01120,map01130 - R02739 RC00563 ko00000,ko00001,ko01000 - - - Aldose_epim,PG_binding_1,SLT_2 k59_256829_1 330214.NIDE3178 1.4e-71 229.0 COG0464@1|root,COG0464@2|Bacteria 2|Bacteria O ATPase activity - - - - - - - - - - - - AAA k59_1049062_1 498211.CJA_1933 5.2e-23 96.3 COG1352@1|root,COG1352@2|Bacteria,1MU6W@1224|Proteobacteria,1RMFK@1236|Gammaproteobacteria,1FGJX@10|Cellvibrio 1236|Gammaproteobacteria NT Methyltransferase, chemotaxis proteins cheR GO:0006935,GO:0008150,GO:0009605,GO:0040011,GO:0042221,GO:0042330,GO:0050896 2.1.1.80 ko:K00575 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko01000,ko02035 - - - CheR,CheR_N k59_1049062_2 675817.VDA_002619 1.58e-25 102.0 COG0784@1|root,COG0835@1|root,COG0784@2|Bacteria,COG0835@2|Bacteria,1N81M@1224|Proteobacteria,1RPS1@1236|Gammaproteobacteria,1XSWX@135623|Vibrionales 135623|Vibrionales T COG0835 Chemotaxis signal transduction protein cheV - - ko:K03415 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko02022,ko02035 - - - CheW,Response_reg k59_1388075_1 1121013.P873_09365 7.77e-58 192.0 COG0300@1|root,COG0300@2|Bacteria,1MWNZ@1224|Proteobacteria,1RQTP@1236|Gammaproteobacteria,1X42F@135614|Xanthomonadales 135614|Xanthomonadales S Belongs to the short-chain dehydrogenases reductases (SDR) family - - - ko:K07124 - - - - ko00000 - - - adh_short k59_1501248_1 641526.ADIWIN_1020 2.19e-50 182.0 2DBXW@1|root,2ZBRY@2|Bacteria,4NM6W@976|Bacteroidetes,1HYMB@117743|Flavobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - DUF5017 k59_1270910_1 1122137.AQXF01000006_gene899 7.15e-111 329.0 COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,2TQQ7@28211|Alphaproteobacteria 28211|Alphaproteobacteria I Belongs to the thiolase family - - - - - - - - - - - - Thiolase_C,Thiolase_N k59_31992_1 502025.Hoch_4479 3.12e-112 343.0 COG1012@1|root,COG1012@2|Bacteria 2|Bacteria C belongs to the aldehyde dehydrogenase family luxC - 1.2.1.50 ko:K03400 ko02020,ko02024,map02020,map02024 - R10549 RC00004,RC00184 ko00000,ko00001,ko01000 - - - LuxC k59_31992_2 1463825.JNXC01000012_gene1864 6.06e-18 82.4 COG0318@1|root,COG0318@2|Bacteria,2HSBK@201174|Actinobacteria,4E92R@85010|Pseudonocardiales 201174|Actinobacteria IQ PFAM AMP-dependent synthetase and ligase - - - - - - - - - - - - LuxE k59_649700_1 1250232.JQNJ01000001_gene3132 1.52e-50 169.0 COG3677@1|root,COG3677@2|Bacteria,4NJC5@976|Bacteroidetes,1I0Y5@117743|Flavobacteriia 976|Bacteroidetes L ISXO2-like transposase domain - - - - - - - - - - - - DDE_Tnp_IS1595,Zn_Tnp_IS1595 k59_819530_1 1116472.MGMO_108c00010 6.32e-85 278.0 COG2010@1|root,COG4885@1|root,COG2010@2|Bacteria,COG4885@2|Bacteria,1R65B@1224|Proteobacteria,1RWBY@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Cytochrome c554 and c-prime - - - - - - - - - - - - Cytochrome_C554,Cytochrome_CBB3 k59_424320_2 240015.ACP_1314 4.1e-26 100.0 COG3293@1|root,COG3293@2|Bacteria 2|Bacteria L Transposase - - - - - - - - - - - - DUF4096,Recombinase,Resolvase,Zn_ribbon_recom k59_709439_1 926550.CLDAP_01170 6.71e-81 258.0 COG0747@1|root,COG0747@2|Bacteria,2G6MN@200795|Chloroflexi 200795|Chloroflexi E PFAM extracellular solute-binding protein, family 5 - - - ko:K02035 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - SBP_bac_5 k59_424330_1 1333998.M2A_1682 1.46e-79 254.0 COG0665@1|root,COG0665@2|Bacteria,1MVGP@1224|Proteobacteria,2TT3Y@28211|Alphaproteobacteria,4BPA5@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria E FAD dependent oxidoreductase ordL - - - - - - - - - - - DAO k59_1049111_1 316407.85676075 1.85e-118 355.0 COG0422@1|root,COG0422@2|Bacteria,1MUVV@1224|Proteobacteria,1RP1F@1236|Gammaproteobacteria,3XMHV@561|Escherichia 1236|Gammaproteobacteria H Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction thiC GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.99.17 ko:K03147 ko00730,ko01100,map00730,map01100 M00127 R03472 RC03251,RC03252 ko00000,ko00001,ko00002,ko01000 - - iECABU_c1320.ECABU_c45100 ThiC-associated,ThiC_Rad_SAM k59_1440390_1 1266925.JHVX01000004_gene1182 1.93e-44 152.0 COG3165@1|root,COG3165@2|Bacteria,1N314@1224|Proteobacteria,2VU2B@28216|Betaproteobacteria,3730H@32003|Nitrosomonadales 28216|Betaproteobacteria S protein conserved in bacteria - - - ko:K03690 - - - - ko00000 - - - SCP2 k59_987844_1 237368.SCABRO_02341 1.07e-16 84.0 COG3437@1|root,COG3437@2|Bacteria,2IZ8V@203682|Planctomycetes 203682|Planctomycetes T cheY-homologous receiver domain - - - ko:K19623 - - - - ko00000,ko02022 - - - HD_5,Response_reg k59_879941_1 929562.Emtol_2576 1.5e-109 343.0 COG0577@1|root,COG0577@2|Bacteria,4NDUK@976|Bacteroidetes,47JJN@768503|Cytophagia 976|Bacteroidetes V FtsX-like permease family - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_1440395_1 768066.HELO_1246 6.98e-20 82.4 COG0093@1|root,COG0093@2|Bacteria,1RCWZ@1224|Proteobacteria,1S3Z3@1236|Gammaproteobacteria,1XJIX@135619|Oceanospirillales 135619|Oceanospirillales J Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome rplN - - ko:K02874 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L14 k59_1109463_1 1218086.BBNB01000001_gene3310 7.32e-81 248.0 COG1609@1|root,COG1609@2|Bacteria,1MVUR@1224|Proteobacteria,1RN2K@1236|Gammaproteobacteria,3WW8B@544|Citrobacter 1236|Gammaproteobacteria K Is the main repressor of the genes involved in the de novo synthesis of purine nucleotides, regulating purB, purC, purEK, purF, purHD, purL, purMN and guaBA expression. PurR is allosterically activated to bind its cognate DNA by binding the purine corepressors, hypoxanthine or guanine, thereby effecting transcription repression purR GO:0001130,GO:0001131,GO:0001141,GO:0001217,GO:0002054,GO:0002057,GO:0002060,GO:0003674,GO:0003700,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006140,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010563,GO:0010605,GO:0010629,GO:0019219,GO:0019220,GO:0019222,GO:0030808,GO:0030809,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0036094,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045934,GO:0045936,GO:0045980,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051174,GO:0051252,GO:0051253,GO:0060255,GO:0062012,GO:0062014,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1900371,GO:1900372,GO:1900542,GO:1900543,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 - ko:K02529,ko:K03604 - - - - ko00000,ko03000 - - - LacI,Peripla_BP_3 k59_995193_1 411684.HPDFL43_18087 2.27e-25 108.0 COG2199@1|root,COG2199@2|Bacteria,1QYCQ@1224|Proteobacteria,2UBEG@28211|Alphaproteobacteria 28211|Alphaproteobacteria T N-terminal 7TM region of histidine kinase - - - - - - - - - - - - GGDEF,HisKA_7TM,PAS_8 k59_1733058_1 312153.Pnuc_1241 3.95e-35 129.0 COG3777@1|root,COG3777@2|Bacteria,1P96N@1224|Proteobacteria,2VIUS@28216|Betaproteobacteria,1K08H@119060|Burkholderiaceae 28216|Betaproteobacteria S N-terminal half of MaoC dehydratase - - 4.2.1.153,4.2.1.56 ko:K09709,ko:K18291 ko00660,ko00720,ko01120,ko01200,map00660,map00720,map01120,map01200 M00376 R02491,R09282 RC00730,RC02479 ko00000,ko00001,ko00002,ko01000 - - - MaoC_dehydrat_N k59_487242_1 748658.KB907314_gene31 5.23e-40 158.0 COG3280@1|root,COG3280@2|Bacteria 2|Bacteria G synthase treY GO:0000272,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0005984,GO:0005991,GO:0005992,GO:0006073,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009251,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016052,GO:0016853,GO:0016866,GO:0030978,GO:0030980,GO:0034637,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044247,GO:0044248,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044275,GO:0044424,GO:0044444,GO:0044464,GO:0046351,GO:0047470,GO:0071704,GO:1901575,GO:1901576 2.4.1.25,5.4.99.15 ko:K00705,ko:K06044 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R01824,R05196,R09995 RC00049 ko00000,ko00001,ko00002,ko01000 - GH13,GH77 - Alpha-amylase,Glyco_hydro_77 k59_1510021_1 1122137.AQXF01000001_gene3171 3.31e-41 144.0 COG5375@1|root,COG5375@2|Bacteria 2|Bacteria S Protein conserved in bacteria - - - ko:K11719 - - - - ko00000,ko02000 1.B.42.1 - - LptC k59_1510021_2 1122137.AQXF01000001_gene3172 2.93e-25 99.4 COG1934@1|root,COG1934@2|Bacteria,1MXGA@1224|Proteobacteria,2U6DD@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Protein conserved in bacteria lptA - - ko:K09774 - - - - ko00000,ko02000 1.B.42.1 - - OstA k59_888825_6 1038858.AXBA01000002_gene3705 6.6e-30 120.0 2DIIY@1|root,303ET@2|Bacteria,1RD2S@1224|Proteobacteria,2U8HK@28211|Alphaproteobacteria,3F229@335928|Xanthobacteraceae 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_718640_1 1336208.JADY01000010_gene3323 9.42e-49 179.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2TQS3@28211|Alphaproteobacteria,2JQ4H@204441|Rhodospirillales 204441|Rhodospirillales T signal transduction protein containing a membrane domain, an EAL and a GGDEF domain - - - - - - - - - - - - EAL,GGDEF,PAS_4,PAS_7,PAS_9,dCache_2 k59_208343_1 316407.1742538 1.68e-119 353.0 COG0246@1|root,COG0246@2|Bacteria,1MVZ7@1224|Proteobacteria,1RNIZ@1236|Gammaproteobacteria,3XME0@561|Escherichia 1236|Gammaproteobacteria G Belongs to the mannitol dehydrogenase family ydfI GO:0003674,GO:0003824,GO:0005975,GO:0005996,GO:0006063,GO:0006064,GO:0006082,GO:0008150,GO:0008152,GO:0008866,GO:0009056,GO:0009987,GO:0016052,GO:0016054,GO:0016491,GO:0016614,GO:0016616,GO:0019585,GO:0019752,GO:0032787,GO:0042839,GO:0042840,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0046365,GO:0046395,GO:0055114,GO:0071704,GO:0072329,GO:1901575 1.1.1.57 ko:K00040 ko00040,ko01100,map00040,map01100 M00061 R02454 RC00085 ko00000,ko00001,ko00002,ko01000 - - iAPECO1_1312.APECO1_2108,iECOK1_1307.ECOK1_4822,iUMN146_1321.UM146_22300,iUTI89_1310.UTI89_C5019 Mannitol_dh,Mannitol_dh_C k59_1510029_2 330214.NIDE3200 1.69e-34 126.0 COG1234@1|root,COG1234@2|Bacteria,3J113@40117|Nitrospirae 40117|Nitrospirae S tRNA 3'-trailer cleavage - - 3.1.26.11 ko:K00784 ko03013,map03013 - - - ko00000,ko00001,ko01000,ko03016 - - - - k59_657380_1 1207055.C100_11535 1.04e-30 118.0 COG2267@1|root,COG2267@2|Bacteria,1QTAP@1224|Proteobacteria,2TU8W@28211|Alphaproteobacteria,2K0IC@204457|Sphingomonadales 204457|Sphingomonadales I Alpha beta hydrolase - - - - - - - - - - - - Abhydrolase_1 k59_657380_2 228405.HNE_0653 2.67e-07 48.9 COG5470@1|root,COG5470@2|Bacteria,1N8V0@1224|Proteobacteria,2UH45@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Domain of unknown function (DUF1330) - - - - - - - - - - - - DUF1330 k59_265571_1 481805.EcolC_1795 5.5e-50 158.0 2E3KM@1|root,32YIX@2|Bacteria,1N7FC@1224|Proteobacteria,1SCUH@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Protein of unknown function (DUF1482) yebW - - - - - - - - - - - DUF1482 k59_265571_2 316407.85675143 9.75e-165 459.0 COG0639@1|root,COG0639@2|Bacteria,1N106@1224|Proteobacteria,1S9QJ@1236|Gammaproteobacteria,3XNX2@561|Escherichia 1236|Gammaproteobacteria T Plays a key role in signaling protein misfolding via the CpxR CPXA transducing system. It also modulates the phosphorylated status of many phosphoproteins in E.coli, some of which acting as major chaperones. Has been shown, in vitro, to act on Ser, Thr and Tyr-phosphorylated substrates pphA GO:0003674,GO:0003824,GO:0004721,GO:0006464,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0008138,GO:0008150,GO:0008152,GO:0009266,GO:0009628,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019538,GO:0036211,GO:0042578,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0050896,GO:0071704,GO:0140096,GO:1901564 3.1.3.16 ko:K07313 - - - - ko00000,ko01000 - - - Metallophos k59_769635_1 395965.Msil_0785 1.64e-36 135.0 COG1721@1|root,COG1721@2|Bacteria,1MWPG@1224|Proteobacteria,2TTDX@28211|Alphaproteobacteria,3N9ZR@45404|Beijerinckiaceae 28211|Alphaproteobacteria S Protein of unknown function DUF58 MA20_44650 - - - - - - - - - - - DUF58 k59_718657_1 1254432.SCE1572_32365 4.78e-68 226.0 COG1022@1|root,COG1022@2|Bacteria,1MU4D@1224|Proteobacteria,42Z0F@68525|delta/epsilon subdivisions,2WTWA@28221|Deltaproteobacteria,2YUMY@29|Myxococcales 28221|Deltaproteobacteria I AMP-binding enzyme - - 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding k59_96434_1 1301098.PKB_3853 4.03e-51 178.0 COG0388@1|root,COG0388@2|Bacteria,1P8FV@1224|Proteobacteria 1224|Proteobacteria S Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source - - - - - - - - - - - - CN_hydrolase k59_96434_2 1122137.AQXF01000002_gene285 7.51e-44 145.0 COG1324@1|root,COG1324@2|Bacteria 2|Bacteria P tolerance protein cutA GO:0003674,GO:0005488,GO:0005507,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009987,GO:0010035,GO:0010038,GO:0016043,GO:0022607,GO:0042221,GO:0043167,GO:0043169,GO:0043933,GO:0044085,GO:0044424,GO:0044464,GO:0046688,GO:0046872,GO:0046914,GO:0050896,GO:0051259,GO:0051260,GO:0065003,GO:0071840 4.2.3.1 ko:K01733,ko:K03926 ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230 M00018 R01466,R05086 RC00017,RC00526 ko00000,ko00001,ko00002,ko01000 - - - CutA1 k59_657401_2 1122137.AQXF01000004_gene1818 9.67e-46 162.0 COG0326@1|root,COG0326@2|Bacteria,1MUUE@1224|Proteobacteria,2TQRS@28211|Alphaproteobacteria 28211|Alphaproteobacteria O Molecular chaperone. Has ATPase activity htpG - - ko:K04079 ko04141,ko04151,ko04217,ko04612,ko04621,ko04626,ko04657,ko04659,ko04914,ko04915,ko05200,ko05215,ko05418,map04141,map04151,map04217,map04612,map04621,map04626,map04657,map04659,map04914,map04915,map05200,map05215,map05418 - - - ko00000,ko00001,ko01009,ko03029,ko03051,ko03110,ko04131,ko04147 - - - HATPase_c,HATPase_c_3,HSP90 k59_657409_1 1535422.ND16A_3223 8.42e-51 175.0 COG0845@1|root,COG0845@2|Bacteria,1NQDN@1224|Proteobacteria,1RRFE@1236|Gammaproteobacteria,2Q6M3@267889|Colwelliaceae 1236|Gammaproteobacteria M Barrel-sandwich domain of CusB or HlyD membrane-fusion - - - ko:K02005 - - - - ko00000 - - - Biotin_lipoyl_2,HlyD_3,HlyD_D23 k59_380304_1 1122137.AQXF01000007_gene3564 1.49e-142 417.0 COG0297@1|root,COG0297@2|Bacteria,1MUGM@1224|Proteobacteria,2TT73@28211|Alphaproteobacteria 28211|Alphaproteobacteria G Synthesizes alpha-1,4-glucan chains using ADP-glucose glgA - 2.4.1.21 ko:K00703 ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026 M00565 R02421 RC00005 ko00000,ko00001,ko00002,ko01000,ko01003 - GT5 - Glyco_transf_5,Glycos_transf_1 k59_888858_1 215803.DB30_6353 2.66e-17 89.7 COG2885@1|root,COG2885@2|Bacteria,1MX1F@1224|Proteobacteria,42UTB@68525|delta/epsilon subdivisions,2WQUW@28221|Deltaproteobacteria,2YUE1@29|Myxococcales 28221|Deltaproteobacteria M Belongs to the ompA family - - - ko:K20276 ko02024,map02024 - - - ko00000,ko00001 - - - Big_3_2,DUF11,OmpA,TSP_3 k59_1278257_2 1202532.FF52_22229 3.39e-94 276.0 2B9U6@1|root,32372@2|Bacteria,4PPY5@976|Bacteroidetes,1I3SG@117743|Flavobacteriia 976|Bacteroidetes S PFAM T4-like virus tail tube protein gp19 - - - - - - - - - - - - Phage_T4_gp19 k59_605578_1 1183438.GKIL_0610 1.28e-22 101.0 COG2374@1|root,COG2374@2|Bacteria,1GHB9@1117|Cyanobacteria 1117|Cyanobacteria G Endonuclease Exonuclease phosphatase - - - ko:K07004 - - - - ko00000 - - - DUF5017,Endonuclease_1,Exo_endo_phos,TIG k59_1733091_1 1282360.ABAC460_10575 4.63e-34 134.0 COG4773@1|root,COG4773@2|Bacteria,1QTXJ@1224|Proteobacteria,2U0KK@28211|Alphaproteobacteria,2KI56@204458|Caulobacterales 204458|Caulobacterales P TonB dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_1397008_1 1122137.AQXF01000004_gene1856 1.31e-53 183.0 COG0457@1|root,COG0457@2|Bacteria,1REXI@1224|Proteobacteria,2UB1S@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Putative 2OG-Fe(II) oxygenase - - - - - - - - - - - - 2OG-FeII_Oxy_5,TPR_16,TPR_19,TPR_8 k59_1397008_2 1122137.AQXF01000004_gene1857 2.16e-32 125.0 COG0457@1|root,COG0457@2|Bacteria,1MVMG@1224|Proteobacteria,2U099@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Sulfotransferase domain - - - - - - - - - - - - Sulfotransfer_3,TPR_16,TPR_2,TPR_8 k59_828482_1 285535.JOEY01000038_gene2761 7.46e-17 79.3 COG1071@1|root,COG1071@2|Bacteria,2GK3W@201174|Actinobacteria 201174|Actinobacteria C Dehydrogenase E1 component acoA - 1.2.4.1 ko:K00161,ko:K21416 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230 M00307 R00014,R00209,R01699,R03270 RC00004,RC00027,RC00627,RC02742,RC02744,RC02882 br01601,ko00000,ko00001,ko00002,ko01000 - - - E1_dh k59_828482_2 991905.SL003B_1036 1.16e-124 362.0 COG0022@1|root,COG0022@2|Bacteria,1R8KB@1224|Proteobacteria,2TRFK@28211|Alphaproteobacteria,4BQ15@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria C Transketolase, pyrimidine binding domain - - 1.2.4.1 ko:K00162,ko:K21417 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230 M00307 R00014,R00209,R01699,R03270 RC00004,RC00027,RC00627,RC02742,RC02744,RC02882 br01601,ko00000,ko00001,ko00002,ko01000 - - - Transket_pyr,Transketolase_C k59_718689_1 477641.MODMU_2503 6.9e-11 69.3 2DB71@1|root,2Z7JE@2|Bacteria,2I2SN@201174|Actinobacteria 201174|Actinobacteria Q Animal haem peroxidase - - - - - - - - - - - - An_peroxidase k59_487293_1 395495.Lcho_3893 2.41e-46 169.0 COG2132@1|root,COG2132@2|Bacteria,1N9H3@1224|Proteobacteria,2VZQA@28216|Betaproteobacteria,1KNDH@119065|unclassified Burkholderiales 28216|Betaproteobacteria Q Multicopper oxidase - - 1.16.3.3 ko:K22349 - - - - ko00000,ko01000 - - - - k59_888868_1 754027.HMPREF9554_01907 2.5e-37 148.0 COG0454@1|root,COG0456@2|Bacteria 2|Bacteria K acetyltransferase - - - - - - - - - - - - Acetyltransf_1 k59_431554_1 344747.PM8797T_05180 4.25e-08 59.7 COG1196@1|root,COG1196@2|Bacteria,2IY32@203682|Planctomycetes 203682|Planctomycetes D Required for chromosome condensation and partitioning smc - - ko:K03529 - - - - ko00000,ko03036 - - - SMC_N,SMC_hinge k59_96462_1 330214.NIDE4063 5.67e-80 248.0 COG1748@1|root,COG1748@2|Bacteria 2|Bacteria E saccharopine dehydrogenase activity lysDH - 1.5.1.7 ko:K00290 ko00300,ko00310,ko01100,ko01110,ko01130,ko01230,map00300,map00310,map01100,map01110,map01130,map01230 M00030,M00032 R00715 RC00217,RC01532 ko00000,ko00001,ko00002,ko01000 - - - ELFV_dehydrog,Sacchrp_dh_C,Sacchrp_dh_NADP k59_1109548_1 1396141.BATP01000039_gene1376 2.07e-48 172.0 COG0443@1|root,COG0443@2|Bacteria,46TYN@74201|Verrucomicrobia,2IU3D@203494|Verrucomicrobiae 203494|Verrucomicrobiae O MreB/Mbl protein - - - - - - - - - - - - HSP70 k59_1224936_1 189753.AXAS01000086_gene6891 1.42e-113 335.0 COG3344@1|root,COG3344@2|Bacteria,1MVI1@1224|Proteobacteria,2U1Z0@28211|Alphaproteobacteria,3K5B6@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria L Group II intron, maturase-specific domain - - 2.7.7.49 ko:K00986,ko:K15342 - - - - ko00000,ko01000,ko02048,ko03400 - - - Cas_Cas1,GIIM,RVT_1 k59_208392_2 570967.JMLV01000016_gene3050 7.58e-32 127.0 COG0506@1|root,COG4230@1|root,COG0506@2|Bacteria,COG4230@2|Bacteria,1MV93@1224|Proteobacteria,2TQPT@28211|Alphaproteobacteria,2JPKY@204441|Rhodospirillales 204441|Rhodospirillales CE Oxidizes proline to glutamate for use as a carbon and nitrogen source putA - 1.2.1.88,1.5.5.2 ko:K13821 ko00250,ko00330,ko01100,ko01110,ko01130,map00250,map00330,map01100,map01110,map01130 - R00245,R00707,R00708,R01253,R04444,R04445,R05051 RC00080,RC00083,RC00216,RC00242,RC00255 ko00000,ko00001,ko01000,ko03000 - - - Aldedh,Pro_dh,Pro_dh-DNA_bdg k59_995262_1 1122137.AQXF01000002_gene300 9.14e-12 64.3 COG0173@1|root,COG0173@2|Bacteria,1MUXB@1224|Proteobacteria,2TR9U@28211|Alphaproteobacteria 28211|Alphaproteobacteria J Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) aspS - 6.1.1.12 ko:K01876 ko00970,map00970 M00359,M00360 R05577 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - GAD,tRNA-synt_2,tRNA_anti-codon k59_995262_2 1122137.AQXF01000002_gene299 3.16e-111 333.0 COG0519@1|root,COG0519@2|Bacteria,1MU2A@1224|Proteobacteria,2TRN0@28211|Alphaproteobacteria 28211|Alphaproteobacteria F Catalyzes the synthesis of GMP from XMP guaA GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046037,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 6.3.5.2 ko:K01951 ko00230,ko00983,ko01100,map00230,map00983,map01100 M00050 R01230,R01231,R08244 RC00010,RC00204 ko00000,ko00001,ko00002,ko01000,ko01002 - - - GATase,GMP_synt_C,NAD_synthase k59_1168970_1 504487.JCM19302_1863 1.02e-78 245.0 COG0772@1|root,COG0772@2|Bacteria,4NFIM@976|Bacteroidetes,1HWQM@117743|Flavobacteriia 976|Bacteroidetes D Belongs to the SEDS family ftsW - - ko:K03588 ko04112,map04112 - - - ko00000,ko00001,ko02000,ko03036 2.A.103.1 - - FTSW_RODA_SPOVE k59_1397050_2 1191523.MROS_0079 2.78e-07 52.8 28I2Y@1|root,2Z86X@2|Bacteria 2|Bacteria - - yetA - - - - - - - - - - - - k59_828531_1 1209072.ALBT01000008_gene2854 1.7e-84 267.0 COG0441@1|root,COG0441@2|Bacteria,1MUP2@1224|Proteobacteria,1RMYE@1236|Gammaproteobacteria,1FGNC@10|Cellvibrio 1236|Gammaproteobacteria J Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) thrS GO:0000166,GO:0000900,GO:0002161,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004812,GO:0004829,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006417,GO:0006418,GO:0006435,GO:0006446,GO:0006450,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0016070,GO:0016787,GO:0016788,GO:0016874,GO:0016875,GO:0017076,GO:0017148,GO:0019222,GO:0019538,GO:0019752,GO:0030371,GO:0030554,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032553,GO:0032555,GO:0032559,GO:0034248,GO:0034249,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045182,GO:0045947,GO:0046483,GO:0046872,GO:0046914,GO:0048027,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0052689,GO:0060255,GO:0065007,GO:0065008,GO:0071704,GO:0080090,GO:0090079,GO:0090304,GO:0097159,GO:0097367,GO:0106074,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:2000112,GO:2000113 6.1.1.3 ko:K01868 ko00970,map00970 M00359,M00360 R03663 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iPC815.YPO2433,iSDY_1059.SDY_1814 HGTP_anticodon,TGS,tRNA-synt_2b,tRNA_SAD k59_1448409_1 1088721.NSU_3450 1.15e-41 146.0 COG1355@1|root,COG1355@2|Bacteria,1R369@1224|Proteobacteria,2TZYM@28211|Alphaproteobacteria,2KEW6@204457|Sphingomonadales 28211|Alphaproteobacteria S Catalytic LigB subunit of aromatic ring-opening dioxygenase - - 1.13.11.16,1.13.11.8 ko:K04101,ko:K05713 ko00360,ko00362,ko00624,ko00627,ko01120,ko01220,map00360,map00362,map00624,map00627,map01120,map01220 M00545 R01632,R03550,R04280,R04376,R06788,R09565 RC00233,RC00387,RC00535,RC01140,RC01364,RC02567,RC02694 br01602,ko00000,ko00001,ko00002,ko01000 - - - LigB k59_1733114_1 1033802.SSPSH_002108 2.21e-127 381.0 COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,1RMQQ@1236|Gammaproteobacteria 1236|Gammaproteobacteria H acetolactate synthase ilvI GO:0000287,GO:0003674,GO:0003824,GO:0003984,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006549,GO:0006573,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009097,GO:0009099,GO:0009987,GO:0016053,GO:0016740,GO:0016744,GO:0019752,GO:0019842,GO:0030976,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046872,GO:0048037,GO:0050662,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1901681 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - iAPECO1_1312.APECO1_1907,iB21_1397.B21_00078,iBWG_1329.BWG_0073,iECBD_1354.ECBD_3539,iECB_1328.ECB_00079,iECD_1391.ECD_00079,iUTI89_1310.UTI89_C0085,iYL1228.KPN_00082 TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_769697_1 1415778.JQMM01000001_gene802 3.89e-58 183.0 COG0781@1|root,COG0781@2|Bacteria,1RHFZ@1224|Proteobacteria,1S6AJ@1236|Gammaproteobacteria,1J67T@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria K Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons nusB GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006353,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576 - ko:K03625 - - - - ko00000,ko03009,ko03021 - - - NusB k59_605630_1 1131266.ARWQ01000010_gene30 5.72e-99 296.0 COG1180@1|root,arCOG00946@2157|Archaea,41SBZ@651137|Thaumarchaeota 651137|Thaumarchaeota C Radical SAM - - 1.97.1.4 ko:K04069 - - R04710 - ko00000,ko01000 - - - Radical_SAM k59_605633_1 228405.HNE_0686 1.06e-53 187.0 COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MU0R@1224|Proteobacteria,2TR3C@28211|Alphaproteobacteria,43WBA@69657|Hyphomonadaceae 28211|Alphaproteobacteria G Belongs to the PEP-utilizing enzyme family ppdK - 2.7.9.1 ko:K01006 ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200 M00169,M00171,M00172,M00173 R00206 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - PEP-utilizers,PEP-utilizers_C,PPDK_N k59_718761_1 1120934.KB894407_gene5007 0.000685 42.4 COG1020@1|root,COG1020@2|Bacteria,2HCKT@201174|Actinobacteria,4E2GW@85010|Pseudonocardiales 201174|Actinobacteria Q Phosphopantetheine attachment site - - - - - - - - - - - - AMP-binding,AMP-binding_C,Condensation,PP-binding k59_718761_2 1500304.JQKY01000031_gene3696 1.43e-25 100.0 COG3502@1|root,COG3502@2|Bacteria,1MZEQ@1224|Proteobacteria,2UBR3@28211|Alphaproteobacteria,4BEP6@82115|Rhizobiaceae 28211|Alphaproteobacteria S protein conserved in bacteria MA20_22095 - - - - - - - - - - - DUF952 k59_718761_3 1122137.AQXF01000001_gene3205 9.69e-171 486.0 COG0167@1|root,COG0167@2|Bacteria,1MU7C@1224|Proteobacteria,2TRF8@28211|Alphaproteobacteria 28211|Alphaproteobacteria F Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor pyrD - 1.3.5.2 ko:K00254 ko00240,ko01100,map00240,map01100 M00051 R01868 RC00051 ko00000,ko00001,ko00002,ko01000 - - - DHO_dh k59_605635_1 745718.JADT01000003_gene2274 2.67e-69 223.0 COG5000@1|root,COG5000@2|Bacteria,4NE49@976|Bacteroidetes,1HXA7@117743|Flavobacteriia 976|Bacteroidetes T Histidine kinase zraS_1 - - - - - - - - - - - HATPase_c,HisKA k59_605635_2 1250232.JQNJ01000001_gene1437 9.75e-12 64.3 COG1024@1|root,COG1024@2|Bacteria,4NFEM@976|Bacteroidetes,1HWQA@117743|Flavobacteriia 976|Bacteroidetes I Belongs to the enoyl-CoA hydratase isomerase family crt - 4.2.1.17 ko:K01715 ko00650,ko01200,map00650,map01200 - R03026 RC00831 ko00000,ko00001,ko01000 - - - ECH_1 k59_150852_1 377629.TERTU_3592 7.35e-91 268.0 COG5405@1|root,COG5405@2|Bacteria,1MVF2@1224|Proteobacteria,1RP7P@1236|Gammaproteobacteria,2PMUX@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria O Proteasome subunit hslV GO:0000166,GO:0000287,GO:0000502,GO:0003674,GO:0003824,GO:0004175,GO:0004298,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009266,GO:0009376,GO:0009408,GO:0009628,GO:0009987,GO:0016043,GO:0016787,GO:0017076,GO:0019538,GO:0019904,GO:0022607,GO:0030163,GO:0030554,GO:0031597,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0034214,GO:0035639,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046872,GO:0050896,GO:0051259,GO:0051603,GO:0065003,GO:0070003,GO:0070011,GO:0071704,GO:0071840,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1904949,GO:1905368,GO:1905369 3.4.25.2 ko:K01419 - - - - ko00000,ko01000,ko01002 - - - Proteasome k59_40812_2 883126.HMPREF9710_04319 1.54e-16 82.8 COG4625@1|root,COG4625@2|Bacteria,1N0QY@1224|Proteobacteria,2VS48@28216|Betaproteobacteria,477EP@75682|Oxalobacteraceae 28216|Betaproteobacteria S pathogenesis - - - - - - - - - - - - - k59_1397087_1 640512.BC1003_3484 3.65e-44 162.0 COG0665@1|root,COG4121@1|root,COG0665@2|Bacteria,COG4121@2|Bacteria,1MZW5@1224|Proteobacteria,2VHGY@28216|Betaproteobacteria,1K1MC@119060|Burkholderiaceae 28216|Betaproteobacteria J Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 mnmC - 2.1.1.61 ko:K15461 - - R00601,R08702 RC00003,RC00053,RC00060,RC01483 ko00000,ko01000,ko03016 - - - DAO,Methyltransf_30 k59_657506_2 1124983.PFLCHA0_c09800 3.97e-28 112.0 28H52@1|root,2Z7HQ@2|Bacteria,1MXTF@1224|Proteobacteria,1RN8H@1236|Gammaproteobacteria,1YN8I@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria S Protein of unknown function (DUF1329) - - - - - - - - - - - - DUF1329 k59_1169003_1 1236501.BAJU01000007_gene1099 1.68e-78 263.0 COG1075@1|root,COG1075@2|Bacteria,1NYAK@1224|Proteobacteria,2UB4D@28211|Alphaproteobacteria,2JWYI@204441|Rhodospirillales 204441|Rhodospirillales S Alpha beta hydrolase - - - - - - - - - - - - Abhydrolase_6 k59_1567603_1 314285.KT71_10102 1.17e-30 118.0 COG0216@1|root,COG0216@2|Bacteria,1MV28@1224|Proteobacteria,1RM7Q@1236|Gammaproteobacteria,1J58N@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA prfA GO:0003674,GO:0003676,GO:0003723,GO:0003747,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008079,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0016149,GO:0019538,GO:0022411,GO:0032984,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - ko:K02835 - - - - ko00000,ko03012 - - - PCRF,RF-1 k59_1567603_2 105559.Nwat_2580 2.86e-29 116.0 COG0373@1|root,COG0373@2|Bacteria,1MU41@1224|Proteobacteria,1RNQ8@1236|Gammaproteobacteria,1WX0A@135613|Chromatiales 135613|Chromatiales H Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) hemA - 1.2.1.70 ko:K02492 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R04109 RC00055,RC00149 ko00000,ko00001,ko00002,ko01000 - - - GlutR_N,GlutR_dimer,Shikimate_DH k59_1278309_1 1381751.JAJB01000032_gene890 1.28e-38 144.0 COG1835@1|root,COG1835@2|Bacteria,2GN56@201174|Actinobacteria,4FAP1@85019|Brevibacteriaceae 201174|Actinobacteria I Acyltransferase family - - - - - - - - - - - - Acyl_transf_3 k59_487373_1 472759.Nhal_3001 9.31e-58 185.0 COG5654@1|root,COG5654@2|Bacteria,1N5WH@1224|Proteobacteria,1T1AI@1236|Gammaproteobacteria 1236|Gammaproteobacteria S PFAM RES domain - - - - - - - - - - - - RES k59_487373_2 1123393.KB891326_gene11 8.07e-20 83.2 COG5642@1|root,COG5642@2|Bacteria,1N1FN@1224|Proteobacteria,2VTKN@28216|Betaproteobacteria,1KT0P@119069|Hydrogenophilales 119069|Hydrogenophilales S Protein of unknown function (DUF2384) - - - - - - - - - - - - DUF2384 k59_380377_1 744980.TRICHSKD4_0393 2.43e-49 176.0 COG1175@1|root,COG1175@2|Bacteria,1MXK1@1224|Proteobacteria,2TUVU@28211|Alphaproteobacteria 28211|Alphaproteobacteria P COG1175 ABC-type sugar transport systems permease components aglF - - ko:K10233 ko02010,map02010 M00201 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.32,3.A.1.1.8 - - BPD_transp_1 k59_1225002_1 1137281.D778_01910 1.44e-93 284.0 COG0826@1|root,COG0826@2|Bacteria,4NERN@976|Bacteroidetes,1HX0F@117743|Flavobacteriia 976|Bacteroidetes O collagenase prtC - - ko:K08303 ko05120,map05120 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_U32 k59_324960_1 314345.SPV1_07606 1.79e-74 231.0 COG0451@1|root,COG0451@2|Bacteria,1MXKV@1224|Proteobacteria 1224|Proteobacteria GM Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto- arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4- amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido- arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides rmlB2 - 4.1.1.35,4.2.1.46 ko:K01710,ko:K08678 ko00520,ko00521,ko00523,ko00525,ko01055,ko01100,ko01130,map00520,map00521,map00523,map00525,map01055,map01100,map01130 M00361,M00793 R01384,R06513 RC00402,RC00508 ko00000,ko00001,ko00002,ko01000 - - - Epimerase,GDP_Man_Dehyd k59_606718_1 318464.IO99_05205 2.22e-21 90.5 COG1468@1|root,COG1468@2|Bacteria,1V2ZQ@1239|Firmicutes,24IH5@186801|Clostridia 186801|Clostridia L CRISPR-associated protein Cas4 - - 3.1.12.1 ko:K07464 - - - - ko00000,ko01000,ko02048 - - - Cas_Cas4 k59_606718_2 373903.Hore_15200 5.37e-25 95.9 COG1343@1|root,COG1343@2|Bacteria,1VDQA@1239|Firmicutes,24Q2T@186801|Clostridia,3WASE@53433|Halanaerobiales 186801|Clostridia L CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette cas2 - - ko:K09951 - - - - ko00000,ko02048 - - - CRISPR_Cas2 k59_1398155_1 566466.NOR53_299 9.73e-31 125.0 COG1061@1|root,COG4951@1|root,COG1061@2|Bacteria,COG4951@2|Bacteria,1MV9F@1224|Proteobacteria,1RNAN@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Type III restriction protein res subunit - - - - - - - - - - - - Helicase_C,ResIII k59_1170041_1 1121374.KB891576_gene171 2.3e-43 156.0 COG0719@1|root,COG0719@2|Bacteria,1MVK0@1224|Proteobacteria,1RP2A@1236|Gammaproteobacteria 1236|Gammaproteobacteria O FeS assembly protein SufD sufD GO:0006790,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0016226,GO:0022607,GO:0031163,GO:0044085,GO:0044237,GO:0050896,GO:0051186,GO:0071840 - ko:K09015 - - - - ko00000 - - iB21_1397.B21_01640,iECBD_1354.ECBD_1964,iECB_1328.ECB_01650,iECD_1391.ECD_01650,iUMNK88_1353.UMNK88_2144 UPF0051 k59_889957_1 316067.Geob_3631 0.0 958.0 COG0086@1|root,COG0086@2|Bacteria,1MU3M@1224|Proteobacteria,42NAW@68525|delta/epsilon subdivisions,2WISU@28221|Deltaproteobacteria 28221|Deltaproteobacteria K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoC - 2.7.7.6 ko:K03046 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5 k59_1568659_1 1122137.AQXF01000002_gene32 8.75e-42 155.0 COG1269@1|root,COG1269@2|Bacteria,1MXZG@1224|Proteobacteria,2TUKE@28211|Alphaproteobacteria 28211|Alphaproteobacteria C transmembrane protein EpsH - - - - - - - - - - - - DUF3485,Exosortase_EpsH k59_381508_1 1122137.AQXF01000001_gene2788 1.78e-203 589.0 COG0060@1|root,COG0060@2|Bacteria,1MVBQ@1224|Proteobacteria,2TR3N@28211|Alphaproteobacteria 28211|Alphaproteobacteria J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) ileS - 6.1.1.5 ko:K01870 ko00970,map00970 M00359,M00360 R03656 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,tRNA-synt_1,zf-FPG_IleRS k59_1517038_1 1122925.KB895384_gene3245 2.62e-149 446.0 COG0495@1|root,COG0495@2|Bacteria,1TP0Y@1239|Firmicutes,4HAG1@91061|Bacilli,26QCH@186822|Paenibacillaceae 91061|Bacilli J Belongs to the class-I aminoacyl-tRNA synthetase family leuS GO:0003674,GO:0003824,GO:0004812,GO:0004823,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006429,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.4 ko:K01869 ko00970,map00970 M00359,M00360 R03657 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - Anticodon_1,tRNA-synt_1,tRNA-synt_1_2 k59_1404571_1 436308.Nmar_0591 1.11e-97 298.0 COG0312@1|root,arCOG00322@2157|Archaea,41T72@651137|Thaumarchaeota 651137|Thaumarchaeota S modulator of DNA gyrase - - - ko:K03592 - - - - ko00000,ko01002 - - - PmbA_TldD k59_103325_1 1048339.KB913029_gene2718 2.47e-150 486.0 COG1028@1|root,COG2070@1|root,COG3321@1|root,COG1028@2|Bacteria,COG2070@2|Bacteria,COG3321@2|Bacteria,2H477@201174|Actinobacteria,4EU82@85013|Frankiales 201174|Actinobacteria Q Beta-ketoacyl synthase - - - - - - - - - - - - Acyl_transf_1,KAsynt_C_assoc,KR,Ketoacyl-synt_C,NMO,PP-binding,PS-DH,ketoacyl-synt k59_664943_1 592029.DDD_1586 1.51e-57 187.0 COG0694@1|root,COG0694@2|Bacteria,4NG0Q@976|Bacteroidetes,1HWKF@117743|Flavobacteriia,3HJ8B@363408|Nonlabens 976|Bacteroidetes O Scaffold protein Nfu/NifU N terminal - - - - - - - - - - - - Nfu_N,NifU k59_1116664_2 717774.Marme_2858 2.44e-45 156.0 COG1073@1|root,COG1073@2|Bacteria,1MUCD@1224|Proteobacteria,1RPCZ@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Dienelactone hydrolase family - - - ko:K06889 - - - - ko00000 - - - DLH,DUF1100,Hydrolase_4,Peptidase_S15,Peptidase_S9 k59_214995_2 1499967.BAYZ01000068_gene1959 2.4e-19 86.7 COG3168@1|root,COG3168@2|Bacteria 2|Bacteria NU Pilus assembly protein, PilP pilP - - ko:K02664,ko:K02665 - - - - ko00000,ko02035,ko02044 - - - PilP k59_664956_1 1123360.thalar_03261 1.24e-20 89.7 COG1968@1|root,COG1968@2|Bacteria,1MX02@1224|Proteobacteria,2TSUR@28211|Alphaproteobacteria 28211|Alphaproteobacteria V Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin uppP GO:0008150,GO:0042221,GO:0046677,GO:0050896 3.6.1.27 ko:K06153 ko00550,map00550 - R05627 RC00002 ko00000,ko00001,ko01000,ko01011 - - - BacA k59_664956_2 1392838.AWNM01000051_gene3016 6.91e-27 109.0 COG1565@1|root,COG1565@2|Bacteria,1N3CJ@1224|Proteobacteria,2VHBE@28216|Betaproteobacteria,3T1WP@506|Alcaligenaceae 28216|Betaproteobacteria S Putative S-adenosyl-L-methionine-dependent methyltransferase - - - - - - - - - - - - Methyltransf_28 k59_1231348_1 111780.Sta7437_0281 6.72e-30 124.0 COG1193@1|root,COG1193@2|Bacteria,1G1GB@1117|Cyanobacteria,3VIAX@52604|Pleurocapsales 1117|Cyanobacteria L Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity mutS2 GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - ko:K07456 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - MutS_V,Smr k59_1063822_1 395494.Galf_1184 1.47e-40 138.0 COG1595@1|root,COG1595@2|Bacteria,1MX7T@1224|Proteobacteria,2VHR2@28216|Betaproteobacteria,44V7B@713636|Nitrosomonadales 28216|Betaproteobacteria K TIGRFAM RNA polymerase sigma factor RpoE rpoE - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 k59_725885_1 196490.AUEZ01000020_gene618 5.54e-25 105.0 COG0604@1|root,COG0604@2|Bacteria,1MXRX@1224|Proteobacteria,2TRSQ@28211|Alphaproteobacteria,3JSKI@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria C Zinc-binding dehydrogenase - - 1.6.5.5 ko:K00344 - - - - ko00000,ko01000 - - - ADH_N,ADH_zinc_N,ADH_zinc_N_2 k59_725885_2 69395.JQLZ01000003_gene451 2.93e-77 256.0 COG0457@1|root,COG0457@2|Bacteria,1MVMG@1224|Proteobacteria,2TSGE@28211|Alphaproteobacteria,2KFVS@204458|Caulobacterales 204458|Caulobacterales S Sulfotransferase - - - - - - - - - - - - Sulfotransfer_3,TPR_14,TPR_16,TPR_19,TPR_8 k59_273042_1 1144307.PMI04_04570 1.9e-70 230.0 COG2072@1|root,COG2072@2|Bacteria,1NSY9@1224|Proteobacteria,2UQPS@28211|Alphaproteobacteria,2K129@204457|Sphingomonadales 204457|Sphingomonadales P Flavin-binding monooxygenase-like - - - - - - - - - - - - FMO-like,NAD_binding_8,Pyr_redox_2,Pyr_redox_3 k59_1682505_1 1156844.KB891820_gene455 8.43e-39 142.0 COG0329@1|root,COG0329@2|Bacteria,2GJ34@201174|Actinobacteria 201174|Actinobacteria E Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) dapA - 4.3.3.7 ko:K01714 ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R10147 RC03062,RC03063 ko00000,ko00001,ko00002,ko01000 - - - DHDPS k59_725910_1 330214.NIDE1108 5.25e-75 250.0 COG1193@1|root,COG1193@2|Bacteria,3J0Y0@40117|Nitrospirae 40117|Nitrospirae L Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity mutS2 - - ko:K07456 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - MutS_V,Smr k59_494150_1 886293.Sinac_0035 6.93e-14 72.8 COG5516@1|root,COG5516@2|Bacteria,2J2SS@203682|Planctomycetes 203682|Planctomycetes S Putative stress-induced transcription regulator - - - - - - - - - - - - ABATE,zf-CGNR k59_1063827_2 290397.Adeh_2689 1.12e-18 87.8 COG0443@1|root,COG0443@2|Bacteria,1MVEN@1224|Proteobacteria,42M64@68525|delta/epsilon subdivisions,2WIWS@28221|Deltaproteobacteria,2YTUT@29|Myxococcales 28221|Deltaproteobacteria O heat shock protein 70 - - - ko:K04043 ko03018,ko04212,ko05152,map03018,map04212,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 1.A.33.1 - - HSP70 k59_1404599_1 1415778.JQMM01000001_gene443 7.65e-92 284.0 COG0469@1|root,COG0469@2|Bacteria,1MU21@1224|Proteobacteria,1RMW3@1236|Gammaproteobacteria,1J5MU@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria G Pyruvate kinase, barrel domain pykF GO:0003674,GO:0003824,GO:0004743,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0016043,GO:0016052,GO:0016053,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0022607,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042802,GO:0042866,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0050896,GO:0051186,GO:0051188,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055086,GO:0065003,GO:0071704,GO:0071840,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576 2.7.1.40 ko:K00873 ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230 M00001,M00002,M00049,M00050 R00200,R00430,R01138,R01858,R02320 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - iECO103_1326.ECO103_1819,iPC815.YPO2393 PK,PK_C k59_1342038_1 1459636.NTE_02862 5.07e-100 310.0 arCOG00144@1|root,arCOG00144@2157|Archaea 2157|Archaea S Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 k59_1342039_1 1121413.JMKT01000008_gene1214 2.64e-11 66.2 COG1752@1|root,COG1752@2|Bacteria,1PGY0@1224|Proteobacteria,42MKJ@68525|delta/epsilon subdivisions,2WK4M@28221|Deltaproteobacteria,2MF8E@213115|Desulfovibrionales 28221|Deltaproteobacteria S Patatin-like phospholipase - - - - - - - - - - - - Patatin k59_1342039_2 566466.NOR53_3467 8.41e-19 85.9 COG1020@1|root,COG1020@2|Bacteria,1N7HY@1224|Proteobacteria,1SMER@1236|Gammaproteobacteria,1J8V8@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Protein of unknown function (DUF1298) - - - - - - - - - - - - DUF1298,WES_acyltransf k59_1285772_2 1961.JOAK01000037_gene2893 3.87e-21 85.5 2E9H4@1|root,333Q5@2|Bacteria,2HCJS@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - - k59_664984_1 1378168.N510_02604 2.74e-06 54.3 COG0497@1|root,COG0497@2|Bacteria,1TP99@1239|Firmicutes 1239|Firmicutes L May be involved in recombinational repair of damaged DNA recN GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009295,GO:0009987,GO:0033554,GO:0034641,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043590,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360 - ko:K03631 - - - - ko00000,ko03400 - - - AAA_23,SMC_N k59_1455429_1 1283300.ATXB01000001_gene2275 2.68e-49 177.0 COG0046@1|root,COG0047@1|root,COG0046@2|Bacteria,COG0047@2|Bacteria,1MYN4@1224|Proteobacteria,1RMRN@1236|Gammaproteobacteria,1XEG1@135618|Methylococcales 135618|Methylococcales F Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate purL - 6.3.5.3 ko:K01952 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04463 RC00010,RC01160 ko00000,ko00001,ko00002,ko01000 - - - AIRS_C,GATase_5 k59_1285777_1 767434.Fraau_3264 3.24e-53 181.0 COG0452@1|root,COG0452@2|Bacteria,1MVQP@1224|Proteobacteria,1RMKQ@1236|Gammaproteobacteria,1X3EH@135614|Xanthomonadales 135614|Xanthomonadales H Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine dfp - 4.1.1.36,6.3.2.5 ko:K13038 ko00770,ko01100,map00770,map01100 M00120 R03269,R04231 RC00064,RC00090,RC00822 ko00000,ko00001,ko00002,ko01000 - - - DFP,Flavoprotein k59_1627271_1 218284.CCDN010000001_gene740 8.7e-92 276.0 COG0274@1|root,COG0274@2|Bacteria,1TPAJ@1239|Firmicutes,4HAAJ@91061|Bacilli,1ZCZ6@1386|Bacillus 91061|Bacilli F Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate deoC - 4.1.2.4 ko:K01619 ko00030,map00030 - R01066 RC00436,RC00437 ko00000,ko00001,ko01000 - - - DeoC k59_1116723_2 1082933.MEA186_08775 2.29e-51 181.0 COG1233@1|root,COG1233@2|Bacteria,1MV2R@1224|Proteobacteria,2TSR0@28211|Alphaproteobacteria,43GY1@69277|Phyllobacteriaceae 28211|Alphaproteobacteria Q Flavin containing amine oxidoreductase - - - - - - - - - - - - Amino_oxidase,NAD_binding_8 k59_1455456_1 316407.85676703 4.89e-128 388.0 COG3979@1|root,COG3979@2|Bacteria,1R5T0@1224|Proteobacteria,1RQXW@1236|Gammaproteobacteria 1236|Gammaproteobacteria G endochitinase activity chiA GO:0003674,GO:0003824,GO:0004553,GO:0004568,GO:0005575,GO:0005623,GO:0008843,GO:0016787,GO:0016798,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0044464 3.2.1.14,3.2.1.17 ko:K13381 ko00520,ko01100,map00520,map01100 - R01206,R02334 RC00467 ko00000,ko00001,ko01000 - CBM15,GH18 - CBM_5_12,Glyco_hydro_18 k59_157811_1 1335757.SPICUR_06985 2.6e-75 231.0 COG0209@1|root,COG0209@2|Bacteria,1P4EH@1224|Proteobacteria,1RP1A@1236|Gammaproteobacteria 1236|Gammaproteobacteria F COG0209 Ribonucleotide reductase, alpha subunit nrdJb - - - - - - - - - - - - k59_157811_2 3988.XP_002537005.1 3.33e-10 58.2 2D61G@1|root,2T0DV@2759|Eukaryota 2759|Eukaryota S SnoaL-like domain - - - - - - - - - - - - SnoaL_4 k59_946879_1 1279038.KB907348_gene3126 6.43e-24 104.0 COG1129@1|root,COG1129@2|Bacteria,1MU22@1224|Proteobacteria,2TQJV@28211|Alphaproteobacteria,2JPHE@204441|Rhodospirillales 204441|Rhodospirillales G Monosaccharide ABC transporter ATP-binding protein, CUT2 family - - 3.6.3.17 ko:K10441 ko02010,map02010 M00212 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.2.1,3.A.1.2.13,3.A.1.2.19 - - ABC_tran k59_438611_1 1088721.NSU_0070 1.27e-84 267.0 COG0608@1|root,COG0608@2|Bacteria,1MU1M@1224|Proteobacteria,2TRZQ@28211|Alphaproteobacteria,2K0VW@204457|Sphingomonadales 204457|Sphingomonadales L single-stranded-DNA-specific exonuclease RecJ recJ - - ko:K07462 ko03410,ko03430,ko03440,map03410,map03430,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DHH,DHHA1 k59_1285789_1 1229909.NSED_00115 3.96e-75 234.0 COG0702@1|root,arCOG03015@2157|Archaea,41T19@651137|Thaumarchaeota 651137|Thaumarchaeota M NAD(P)H-binding - - 1.6.5.3,1.6.99.3 ko:K00329,ko:K00356 ko00190,map00190 - R11945 RC00061 ko00000,ko00001,ko01000 - - - NAD_binding_10 k59_157813_2 1123519.PSJM300_06255 2.25e-18 79.3 COG3100@1|root,COG3100@2|Bacteria,1N83J@1224|Proteobacteria,1SCCD@1236|Gammaproteobacteria,1Z39W@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria S YcgL domain-containing protein ycgL - - ko:K09902 - - - - ko00000 - - - YcgL k59_612791_1 1123237.Salmuc_02197 6.71e-16 77.0 COG1414@1|root,COG1414@2|Bacteria,1RA2W@1224|Proteobacteria 1224|Proteobacteria K Transcriptional regulator - - - - - - - - - - - - HTH_IclR,IclR k59_1175419_1 948565.AFFP02000002_gene1254 5.47e-83 256.0 COG0040@1|root,COG0040@2|Bacteria,1MUCY@1224|Proteobacteria,1RNAX@1236|Gammaproteobacteria,1Y6ZD@135625|Pasteurellales 135625|Pasteurellales F ATP phosphoribosyltransferase hisG GO:0000105,GO:0003674,GO:0003824,GO:0003879,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.17 ko:K00765 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R01071 RC02819,RC03200 ko00000,ko00001,ko00002,ko01000 - - - HisG,HisG_C k59_387616_1 481448.Minf_0041 2.35e-35 129.0 COG2010@1|root,COG2010@2|Bacteria,46YH9@74201|Verrucomicrobia,37GM8@326457|unclassified Verrucomicrobia 74201|Verrucomicrobia C Cytochrome c norC - - ko:K02305 ko00910,ko01120,map00910,map01120 M00529 R00294 RC02794 ko00000,ko00001,ko00002 3.D.4.10 - - Cytochrom_C k59_103438_1 1042375.AFPL01000044_gene1289 1.18e-88 273.0 COG0004@1|root,COG0004@2|Bacteria,1NR9F@1224|Proteobacteria,1RNKF@1236|Gammaproteobacteria,4652P@72275|Alteromonadaceae 1236|Gammaproteobacteria P Ammonium transporter amtB - - ko:K03320 - - - - ko00000,ko02000 1.A.11 - - Ammonium_transp k59_549764_1 319236.JCM19294_963 9.51e-68 216.0 COG0508@1|root,COG0508@2|Bacteria,4NJ7Y@976|Bacteroidetes,1HZXY@117743|Flavobacteriia 976|Bacteroidetes C dehydrogenase complex catalyzes the overall conversion of - - - - - - - - - - - - - k59_1627294_1 404589.Anae109_4467 6.35e-62 201.0 COG1100@1|root,COG1100@2|Bacteria,1RCJJ@1224|Proteobacteria,42R57@68525|delta/epsilon subdivisions,2WN5Y@28221|Deltaproteobacteria,2YUYK@29|Myxococcales 28221|Deltaproteobacteria S Small GTP-binding protein - - - ko:K06883 - - - - ko00000 - - - Arf k59_1627298_1 331869.BAL199_02229 5.77e-28 116.0 COG0529@1|root,COG2895@1|root,COG0529@2|Bacteria,COG2895@2|Bacteria,1MUD9@1224|Proteobacteria,2TQNJ@28211|Alphaproteobacteria,4BPC0@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria P Catalyzes the synthesis of activated sulfate cysC - 2.7.1.25,2.7.7.4 ko:K00955 ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130 M00176 R00509,R00529,R04928,R04929 RC00002,RC00078,RC02809,RC02889 ko00000,ko00001,ko00002,ko01000 - - - APS_kinase,GTP_EFTU k59_612809_1 1122137.AQXF01000005_gene1168 4.35e-48 160.0 COG5553@1|root,COG5553@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - CDO_I k59_946930_1 1125863.JAFN01000001_gene2499 2.29e-47 165.0 COG0126@1|root,COG0126@2|Bacteria,1MUNU@1224|Proteobacteria,42N4P@68525|delta/epsilon subdivisions,2WJ0B@28221|Deltaproteobacteria 28221|Deltaproteobacteria F Belongs to the phosphoglycerate kinase family pgk - 2.7.2.3 ko:K00927 ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01512 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000,ko04147 - - - PGK k59_1739792_1 1506583.JQJY01000002_gene1800 8.45e-70 235.0 COG4206@1|root,COG4206@2|Bacteria,4P258@976|Bacteroidetes,1IJ92@117743|Flavobacteriia,2P0MC@237|Flavobacterium 976|Bacteroidetes H TonB-dependent receptor - - - - - - - - - - - - CarbopepD_reg_2,Plug,TonB_dep_Rec k59_103467_1 666681.M301_0068 5.86e-05 48.1 COG0642@1|root,COG2205@2|Bacteria,1N1Z2@1224|Proteobacteria,2VJBG@28216|Betaproteobacteria 28216|Betaproteobacteria T Histidine kinase qseC - 2.7.13.3 ko:K07645 ko02020,ko02024,map02020,map02024 M00453 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - 2CSK_N,HATPase_c,HisKA k59_103467_2 1049564.TevJSym_al00140 5.48e-23 94.0 COG0745@1|root,COG0745@2|Bacteria,1N0YI@1224|Proteobacteria,1RQQ3@1236|Gammaproteobacteria,1J647@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria K Transcriptional regulatory protein, C terminal lrpR - - ko:K07666 ko02020,ko02024,map02020,map02024 M00453 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Trans_reg_C k59_1456689_1 887898.HMPREF0551_1270 6.81e-74 245.0 COG1298@1|root,COG1298@2|Bacteria,1MUF3@1224|Proteobacteria,2VHVC@28216|Betaproteobacteria,1K00K@119060|Burkholderiaceae 28216|Betaproteobacteria N Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin flhA - - ko:K02400 ko02040,map02040 - - - ko00000,ko00001,ko02035,ko02044 3.A.6.2,3.A.6.3 - - FHIPEP k59_613890_1 1163617.SCD_n02817 7.98e-65 213.0 COG1611@1|root,COG1611@2|Bacteria,1MVQJ@1224|Proteobacteria,2W0HG@28216|Betaproteobacteria 28216|Betaproteobacteria S Domain of unknown function (DUF4478) - - 3.2.2.10 ko:K06966 ko00230,ko00240,map00230,map00240 - R00182,R00510 RC00063,RC00318 ko00000,ko00001,ko01000 - - - DUF3412,DUF4478,Lysine_decarbox k59_1003589_2 1313172.YM304_09590 9.68e-24 102.0 COG3764@1|root,COG3764@2|Bacteria,2GKT6@201174|Actinobacteria,4CNXW@84992|Acidimicrobiia 84992|Acidimicrobiia M Sortase family - - 3.4.22.70 ko:K07284 - - - - ko00000,ko01000,ko01002,ko01011 - - - Sortase k59_948039_1 251221.35213235 5.31e-07 52.0 COG2805@1|root,COG2805@2|Bacteria,1G0HI@1117|Cyanobacteria 1117|Cyanobacteria NU COG2805 Tfp pilus assembly protein, pilus retraction ATPase PilT pilT - - ko:K02669 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE k59_948039_2 1397527.Q670_04485 4.37e-73 239.0 COG0073@1|root,COG0143@1|root,COG0073@2|Bacteria,COG0143@2|Bacteria,1MUBY@1224|Proteobacteria,1RMYM@1236|Gammaproteobacteria,1XHBT@135619|Oceanospirillales 135619|Oceanospirillales J Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation metG - 6.1.1.10 ko:K01874 ko00450,ko00970,map00450,map00970 M00359,M00360 R03659,R04773 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,tRNA-synt_1g,tRNA_bind k59_550812_1 743720.Psefu_3263 0.000101 50.4 COG2304@1|root,COG2373@1|root,COG2931@1|root,COG2304@2|Bacteria,COG2373@2|Bacteria,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,1RMZW@1236|Gammaproteobacteria,1YZKD@136845|Pseudomonas putida group 1236|Gammaproteobacteria Q von Willebrand factor (vWF) type A domain lapA - - ko:K12549 - - - - ko00000 - - - Big_3_2,Cadherin_3,Calx-beta,HemolysinCabind,VWA,VWA_2 k59_1740784_2 1442599.JAAN01000011_gene379 1.15e-14 77.4 COG0457@1|root,COG0457@2|Bacteria,1MXK4@1224|Proteobacteria,1RNFM@1236|Gammaproteobacteria,1X3AP@135614|Xanthomonadales 135614|Xanthomonadales S Oxygen tolerance - - - - - - - - - - - - BatD k59_1683616_1 5465.ENH85688 3.27e-26 105.0 COG4225@1|root,2QT25@2759|Eukaryota,3983X@33154|Opisthokonta,3NWXE@4751|Fungi,3QNQH@4890|Ascomycota,2161W@147550|Sordariomycetes,1EXTD@1028384|Glomerellales 4751|Fungi G Glycosyl hydrolase family - - 3.2.1.172 ko:K15532 - - - - ko00000,ko01000 - GH105 - Glyco_hydro_88 k59_1518201_1 665571.STHERM_c04540 2.64e-46 162.0 COG0707@1|root,COG0707@2|Bacteria,2J9T2@203691|Spirochaetes 203691|Spirochaetes M Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) - - - - - - - - - - - - - k59_1176468_2 1095769.CAHF01000022_gene41 5.99e-87 267.0 COG1024@1|root,COG1024@2|Bacteria,1MUD7@1224|Proteobacteria,2VQ37@28216|Betaproteobacteria 28216|Betaproteobacteria I Pfam Enoyl-CoA hydratase isomerase - - - ko:K13816 ko02020,ko02024,map02020,map02024 - - - ko00000,ko00001 - - - ECH_1 k59_1628364_1 1122962.AULH01000009_gene3808 9.87e-81 249.0 COG1028@1|root,COG1028@2|Bacteria,1P9R4@1224|Proteobacteria,2TSIF@28211|Alphaproteobacteria,370H2@31993|Methylocystaceae 28211|Alphaproteobacteria IQ Enoyl-(Acyl carrier protein) reductase - - - - - - - - - - - - adh_short k59_274151_1 316407.85676475 2.6e-103 308.0 COG4214@1|root,COG4214@2|Bacteria,1MXXS@1224|Proteobacteria,1RNWF@1236|Gammaproteobacteria,3XP4K@561|Escherichia 1236|Gammaproteobacteria G Part of the binding-protein-dependent transport system for D-xylose. Probably responsible for the translocation of the substrate across the membrane xylH GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0005996,GO:0006810,GO:0008150,GO:0008152,GO:0008643,GO:0015144,GO:0015145,GO:0015749,GO:0016020,GO:0016021,GO:0019321,GO:0022857,GO:0031224,GO:0034219,GO:0042732,GO:0044238,GO:0044281,GO:0044425,GO:0044464,GO:0051119,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071704,GO:0071944 - ko:K10544,ko:K10547 ko02010,map02010 M00215,M00216 - - ko00000,ko00001,ko00002,ko02000 3.A.1.2.4,3.A.1.2.5 - iEC55989_1330.EC55989_4023 BPD_transp_2 k59_274151_2 199310.c4387 9.51e-15 72.8 COG1129@1|root,COG1129@2|Bacteria,1MU22@1224|Proteobacteria,1RMCH@1236|Gammaproteobacteria,3XPAB@561|Escherichia 1236|Gammaproteobacteria G Part of the ABC transporter complex XylFGH involved in xylose import. Responsible for energy coupling to the transport system xylG GO:0000166,GO:0003674,GO:0005215,GO:0005488,GO:0005524,GO:0005975,GO:0005996,GO:0006810,GO:0008144,GO:0008150,GO:0008152,GO:0008643,GO:0015144,GO:0015145,GO:0015146,GO:0015148,GO:0015749,GO:0015750,GO:0015753,GO:0017076,GO:0019321,GO:0022857,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034219,GO:0035639,GO:0036094,GO:0042732,GO:0043167,GO:0043168,GO:0044238,GO:0044281,GO:0051119,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901363 3.6.3.17 ko:K02056,ko:K10441,ko:K10542,ko:K10545,ko:K10551 ko02010,map02010 M00212,M00214,M00215,M00217,M00221 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.2,3.A.1.2.1,3.A.1.2.13,3.A.1.2.19,3.A.1.2.3,3.A.1.2.4,3.A.1.2.6 - iEC55989_1330.EC55989_4224,iECABU_c1320.ECABU_c40100,iECED1_1282.ECED1_4821,iECED1_1282.ECED1_5085,iECH74115_1262.ECH74115_3282,iECNA114_1301.ECNA114_4270,iECP_1309.ECP_3670,iECSE_1348.ECSE_4039,iECSP_1301.ECSP_3027,iECW_1372.ECW_m4052,iEcE24377_1341.EcE24377A_4265,iSF_1195.SF3611,iS_1188.S4158,iWFL_1372.ECW_m4052 ABC_tran k59_1405676_1 323848.Nmul_A0857 1.52e-83 273.0 COG0567@1|root,COG0567@2|Bacteria,1MVBF@1224|Proteobacteria,2VJ0G@28216|Betaproteobacteria,371W3@32003|Nitrosomonadales 28216|Betaproteobacteria C dehydrogenase, E1 component sucA - 1.2.4.2 ko:K00164 ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00032 R00621,R01933,R01940,R03316,R08549 RC00004,RC00027,RC00627,RC02743,RC02833,RC02883 br01601,ko00000,ko00001,ko00002,ko01000 - - - 2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr k59_1793136_1 264730.PSPPH_3513 2.69e-89 272.0 COG2008@1|root,COG2008@2|Bacteria,1MWCR@1224|Proteobacteria,1RNYX@1236|Gammaproteobacteria,1Z62E@136849|Pseudomonas syringae group 1236|Gammaproteobacteria E Threonine aldolase ltaE GO:0003674,GO:0003824,GO:0004793,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006566,GO:0006567,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008732,GO:0009056,GO:0009063,GO:0009066,GO:0009068,GO:0009987,GO:0016054,GO:0016829,GO:0016830,GO:0016832,GO:0019752,GO:0019842,GO:0030170,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0048037,GO:0050179,GO:0050662,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 4.1.2.48,4.1.2.49 ko:K01620,ko:K20801 ko00260,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map01100,map01110,map01120,map01130,map01230 - R00751,R06171 RC00312,RC00372 ko00000,ko00001,ko01000 - - iECNA114_1301.ECNA114_0812,iECSF_1327.ECSF_0795 Beta_elim_lyase k59_1456742_1 1267005.KB911257_gene1161 2.98e-194 575.0 COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,2TRWM@28211|Alphaproteobacteria 28211|Alphaproteobacteria P Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K15726 - - - - ko00000,ko02000 2.A.6.1.2 - - ACR_tran k59_1628378_1 1122137.AQXF01000003_gene2162 2.69e-42 154.0 COG0823@1|root,COG0823@2|Bacteria,1MV09@1224|Proteobacteria,2TR03@28211|Alphaproteobacteria 28211|Alphaproteobacteria U Involved in the TonB-independent uptake of proteins tolB - - ko:K03641 - - - - ko00000,ko02000 2.C.1.2 - - PD40,TolB_N k59_1683646_1 1120949.KB903303_gene6763 5.91e-36 133.0 COG2267@1|root,COG2267@2|Bacteria,2I44E@201174|Actinobacteria,4DAVR@85008|Micromonosporales 201174|Actinobacteria I alpha/beta hydrolase fold - - - - - - - - - - - - Abhydrolase_1,Abhydrolase_6 k59_1518218_2 1088721.NSU_3430 6.71e-51 169.0 COG1355@1|root,COG1355@2|Bacteria,1R369@1224|Proteobacteria,2TZYM@28211|Alphaproteobacteria,2KEW6@204457|Sphingomonadales 28211|Alphaproteobacteria S Catalytic LigB subunit of aromatic ring-opening dioxygenase - - 1.13.11.16,1.13.11.8 ko:K04101,ko:K05713 ko00360,ko00362,ko00624,ko00627,ko01120,ko01220,map00360,map00362,map00624,map00627,map01120,map01220 M00545 R01632,R03550,R04280,R04376,R06788,R09565 RC00233,RC00387,RC00535,RC01140,RC01364,RC02567,RC02694 br01602,ko00000,ko00001,ko00002,ko01000 - - - LigB k59_331847_1 1121937.AUHJ01000004_gene1057 2.91e-82 253.0 COG0057@1|root,COG0057@2|Bacteria,1NT8P@1224|Proteobacteria,1SJQU@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain - - - - - - - - - - - - Gp_dh_C,Gp_dh_N k59_1683655_1 1392488.JHZY01000004_gene3198 7.29e-39 147.0 COG1874@1|root,COG1874@2|Bacteria,4NDX1@976|Bacteroidetes,1HXQ9@117743|Flavobacteriia,2XJY4@283735|Leeuwenhoekiella 976|Bacteroidetes G Glycosyl hydrolases family 35 - - - - - - - - - - - - Glyco_hydro_35,Glyco_hydro_42 k59_109706_2 316407.85676284 1.19e-110 330.0 COG0477@1|root,COG0477@2|Bacteria,1QTWJ@1224|Proteobacteria,1T1QY@1236|Gammaproteobacteria,3XNAU@561|Escherichia 1236|Gammaproteobacteria EGP Major facilitator superfamily yieO GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944 - - - - - - - - - - MFS_1,MFS_3,TRI12 k59_671066_1 395965.Msil_3774 2.74e-107 335.0 COG1251@1|root,COG1251@2|Bacteria,1MW58@1224|Proteobacteria,2TS8I@28211|Alphaproteobacteria,3NAQ3@45404|Beijerinckiaceae 28211|Alphaproteobacteria C Pyridine nucleotide-disulphide oxidoreductase - - 1.7.1.15 ko:K00362 ko00910,ko01120,map00910,map01120 M00530 R00787 RC00176 ko00000,ko00001,ko00002,ko01000 - - - Fer2_BFD,NIR_SIR,NIR_SIR_ferr,Pyr_redox_2,Rieske_2 k59_556029_1 1123239.KB898623_gene1617 0.000837 47.4 COG0028@1|root,COG0028@2|Bacteria,1TQE8@1239|Firmicutes,4H9VR@91061|Bacilli 91061|Bacilli EH Acetolactate synthase - - - - - - - - - - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_1348243_1 1500306.JQLA01000003_gene4621 1.12e-63 206.0 COG3191@1|root,COG3191@2|Bacteria,1MWDP@1224|Proteobacteria,2TUI2@28211|Alphaproteobacteria,4BAUG@82115|Rhizobiaceae 28211|Alphaproteobacteria EQ Peptidase family S58 - - 3.4.11.19 ko:K01266 - - - - ko00000,ko01000,ko01002 - - - Peptidase_S58 k59_1122881_1 1121374.KB891585_gene1981 4.24e-77 254.0 COG0439@1|root,COG0511@1|root,COG0439@2|Bacteria,COG0511@2|Bacteria,1N71M@1224|Proteobacteria,1RYJ9@1236|Gammaproteobacteria 1236|Gammaproteobacteria I COG0439 Biotin carboxylase - - - - - - - - - - - - Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2 k59_1181592_1 394.NGR_c27910 3.13e-06 48.9 COG2255@1|root,COG2255@2|Bacteria,1MU38@1224|Proteobacteria,2TQNG@28211|Alphaproteobacteria,4BACQ@82115|Rhizobiaceae 28211|Alphaproteobacteria L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing ruvB GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0050896,GO:0051716,GO:0071496 3.6.4.12 ko:K03551 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - RuvB_C,RuvB_N k59_1181592_2 1122137.AQXF01000003_gene2158 2.49e-75 228.0 COG0824@1|root,COG0824@2|Bacteria 2|Bacteria IQ Thioesterase ybgC - - ko:K07107 - - - - ko00000,ko01000 - - - 4HBT,4HBT_2 k59_1348262_1 497965.Cyan7822_1716 2.57e-28 118.0 COG0834@1|root,COG2202@1|root,COG5001@1|root,COG0834@2|Bacteria,COG2202@2|Bacteria,COG5001@2|Bacteria,1G0SY@1117|Cyanobacteria,3KGUV@43988|Cyanothece 1117|Cyanobacteria T GGDEF domain containing protein - - - - - - - - - - - - EAL,GAF,GGDEF,HAMP,PAS,PAS_3,PAS_4,PAS_9,Response_reg,SBP_bac_3,dCache_1 k59_1523258_1 1096930.L284_00875 1.7e-118 350.0 COG0628@1|root,COG0628@2|Bacteria,1MVX7@1224|Proteobacteria,2TVGG@28211|Alphaproteobacteria,2K0BX@204457|Sphingomonadales 204457|Sphingomonadales S AI-2E family transporter - - - - - - - - - - - - AI-2E_transport k59_393995_1 1298593.TOL_0290 0.000509 45.8 COG0500@1|root,COG0640@1|root,COG0500@2|Bacteria,COG0640@2|Bacteria,1NFSV@1224|Proteobacteria,1RQT6@1236|Gammaproteobacteria,1XIPM@135619|Oceanospirillales 135619|Oceanospirillales K ArsR family transcriptional regulator - - - - - - - - - - - - HTH_20,HTH_5,Methyltransf_11,Methyltransf_23 k59_1292219_1 436308.Nmar_1290 1.17e-107 315.0 COG0548@1|root,arCOG00862@2157|Archaea,41SFB@651137|Thaumarchaeota 651137|Thaumarchaeota E Involved in both the arginine and lysine biosynthetic pathways. Phosphorylates the LysW-bound precursors glutamate (for arginine biosynthesis), respectively alpha-aminoadipate (for lysine biosynthesis) lysZ - - ko:K05828 ko00220,ko00300,ko01100,ko01110,ko01210,ko01230,map00220,map00300,map01100,map01110,map01210,map01230 M00031,M00763 R09776,R10930 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase k59_1292219_2 436308.Nmar_1291 3.46e-60 195.0 COG4992@1|root,arCOG00914@2157|Archaea,41SC8@651137|Thaumarchaeota 651137|Thaumarchaeota E Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family lysJ - - ko:K05830 ko00220,ko00300,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01130,map01210,map01230 M00031,M00763 R09778,R10932 RC00006,RC00062 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 k59_164104_1 556268.OFAG_02314 4.33e-09 55.8 COG3108@1|root,COG3108@2|Bacteria,1PG9K@1224|Proteobacteria,2WCM4@28216|Betaproteobacteria,477VP@75682|Oxalobacteraceae 28216|Betaproteobacteria S Peptidase M15 - - - - - - - - - - - - Peptidase_M15_3 k59_1237390_1 572477.Alvin_1635 1.03e-21 90.5 COG0558@1|root,COG0558@2|Bacteria,1MZ8B@1224|Proteobacteria,1SAHT@1236|Gammaproteobacteria,1WY27@135613|Chromatiales 135613|Chromatiales I PFAM CDP-alcohol phosphatidyltransferase - - 2.7.8.41 ko:K08744 ko00564,ko01100,map00564,map01100 - R02030 RC00002,RC00017 ko00000,ko00001,ko01000 - - - CDP-OH_P_transf k59_1069917_1 926569.ANT_30110 5.49e-67 212.0 COG0860@1|root,COG0860@2|Bacteria,2G7IE@200795|Chloroflexi 200795|Chloroflexi M PFAM cell wall hydrolase autolysin - - 3.5.1.28 ko:K01448 ko01503,map01503 M00727 R04112 RC00064,RC00141 ko00000,ko00001,ko00002,ko01000,ko01011,ko03036 - - - Amidase_3 k59_1348272_1 861299.J421_0108 3.25e-162 493.0 COG0392@1|root,COG2898@1|root,COG0392@2|Bacteria,COG2898@2|Bacteria,1ZURV@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Uncharacterised conserved protein (DUF2156) - - 2.3.2.3 ko:K14205 ko01503,ko02020,ko05150,map01503,map02020,map05150 M00726 - - ko00000,ko00001,ko00002,ko01000,ko01504 2.A.1.3.37 - - DUF2156,LPG_synthase_TM k59_109739_1 626887.J057_09151 2.27e-17 81.3 COG3764@1|root,COG3764@2|Bacteria,1P806@1224|Proteobacteria,1S9RI@1236|Gammaproteobacteria,467ZM@72275|Alteromonadaceae 1236|Gammaproteobacteria M COG3764 Sortase (surface protein transpeptidase) srtA - 3.4.22.70 ko:K07284 - - - - ko00000,ko01000,ko01002,ko01011 - - - Sortase k59_109739_2 1403819.BATR01000164_gene5524 2.74e-32 116.0 COG0454@1|root,COG0456@2|Bacteria,46SWZ@74201|Verrucomicrobia,2IVZ7@203494|Verrucomicrobiae 203494|Verrucomicrobiae K FR47-like protein - - - - - - - - - - - - Acetyltransf_1 k59_953141_2 1122169.AREN01000019_gene2032 7.08e-49 169.0 COG3200@1|root,COG3200@2|Bacteria,1MUWF@1224|Proteobacteria,1RRMM@1236|Gammaproteobacteria,1JCXW@118969|Legionellales 118969|Legionellales E Class-II DAHP synthetase family dhs1 - 2.5.1.54 ko:K01626 ko00400,ko01100,ko01110,ko01130,ko01230,ko02024,map00400,map01100,map01110,map01130,map01230,map02024 M00022 R01826 RC00435 ko00000,ko00001,ko00002,ko01000 - - - DAHP_synth_2 k59_953142_1 1229909.NSED_02360 2.13e-41 139.0 COG0457@1|root,arCOG03032@2157|Archaea,41T5X@651137|Thaumarchaeota 651137|Thaumarchaeota S Tetratricopeptide repeat - - - - - - - - - - - - TPR_19 k59_1798193_1 1121033.AUCF01000024_gene268 1.46e-117 355.0 COG1894@1|root,COG1905@1|root,COG1894@2|Bacteria,COG1905@2|Bacteria,1MV8F@1224|Proteobacteria,2TR1V@28211|Alphaproteobacteria,2JQZQ@204441|Rhodospirillales 204441|Rhodospirillales C COG1905 NADH ubiquinone oxidoreductase 24 kD subunit - - - - - - - - - - - - 2Fe-2S_thioredx,Complex1_51K,NADH_4Fe-4S,SLBB k59_279332_1 1230476.C207_02717 9.31e-15 79.3 COG0840@1|root,COG4192@1|root,COG0840@2|Bacteria,COG4192@2|Bacteria,1MU9B@1224|Proteobacteria,2TQR7@28211|Alphaproteobacteria,3JSEI@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria NT chemotaxis - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - HAMP,MCPsignal k59_279332_2 1122137.AQXF01000002_gene489 3.71e-44 156.0 COG1012@1|root,COG1012@2|Bacteria,1MVGW@1224|Proteobacteria,2TR9T@28211|Alphaproteobacteria 28211|Alphaproteobacteria C belongs to the aldehyde dehydrogenase family calB - 1.2.1.68,1.2.99.10 ko:K00154,ko:K22445 - - - - ko00000,ko01000 - - - Aldedh k59_1745849_1 436308.Nmar_0313 5.75e-82 247.0 COG1443@1|root,arCOG01081@2157|Archaea,41T09@651137|Thaumarchaeota 651137|Thaumarchaeota I NUDIX domain - - 5.3.3.2 ko:K01823 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00095,M00096,M00364,M00365,M00366,M00367 R01123 RC00455 ko00000,ko00001,ko00002,ko01000 - - - NUDIX k59_1348289_2 1123376.AUIU01000016_gene309 6.47e-57 184.0 COG0528@1|root,COG0528@2|Bacteria,3J0BE@40117|Nitrospirae 40117|Nitrospirae F Catalyzes the reversible phosphorylation of UMP to UDP pyrH - 2.7.4.22 ko:K09903 ko00240,ko01100,map00240,map01100 - R00158 RC00002 ko00000,ko00001,ko01000 - - - AA_kinase k59_444976_1 342610.Patl_2657 4.49e-83 261.0 COG3693@1|root,COG3693@2|Bacteria,1PX42@1224|Proteobacteria,1RQ0K@1236|Gammaproteobacteria,2Q14C@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria G Glycosyl hydrolase family 10 - - 3.2.1.8 ko:K01181 - - - - ko00000,ko01000 - - - Glyco_hydro_10 k59_671102_1 205922.Pfl01_0990 1.67e-21 92.4 COG0795@1|root,COG0795@2|Bacteria,1MUF2@1224|Proteobacteria,1RMN5@1236|Gammaproteobacteria,1YPTX@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria S Permease lptF - - ko:K07091 ko02010,map02010 M00320 - - ko00000,ko00001,ko00002,ko02000 1.B.42.1 - - YjgP_YjgQ k59_1292241_1 398767.Glov_3556 5.45e-34 134.0 COG4206@1|root,COG4206@2|Bacteria,1MW63@1224|Proteobacteria,43BRF@68525|delta/epsilon subdivisions,2WKAH@28221|Deltaproteobacteria,43TV7@69541|Desulfuromonadales 28221|Deltaproteobacteria P TonB dependent receptor btuB - - ko:K02014,ko:K16092 - - - - ko00000,ko02000 1.B.14,1.B.14.3 - - Plug,TonB_dep_Rec k59_1292243_1 1166948.JPZL01000003_gene629 8.69e-17 81.6 COG3245@1|root,COG3245@2|Bacteria,1MZBZ@1224|Proteobacteria,1S9Z9@1236|Gammaproteobacteria,1XKPZ@135619|Oceanospirillales 135619|Oceanospirillales C cytochrome c5 - - - - - - - - - - - - Cytochrome_CBB3 k59_1461981_1 290397.Adeh_0511 2e-51 176.0 COG0475@1|root,COG0475@2|Bacteria,1RA3J@1224|Proteobacteria,43EWJ@68525|delta/epsilon subdivisions,2WTW1@28221|Deltaproteobacteria 28221|Deltaproteobacteria P Sodium/hydrogen exchanger family - - - - - - - - - - - - Na_H_Exchanger k59_1798201_1 987059.RBXJA2T_16672 4.12e-20 100.0 COG0784@1|root,COG2202@1|root,COG3829@1|root,COG5002@1|root,COG0784@2|Bacteria,COG2202@2|Bacteria,COG3829@2|Bacteria,COG5002@2|Bacteria,1NC9X@1224|Proteobacteria,2WGIN@28216|Betaproteobacteria,1KPMM@119065|unclassified Burkholderiales 28216|Betaproteobacteria T histidine kinase A domain protein - - 2.7.13.3 ko:K11527,ko:K20973 ko02020,ko02025,map02020,map02025 M00820 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA,Hpt,PAS_4,PAS_9,Response_reg k59_280304_1 322710.Avin_34160 3.51e-24 99.4 COG1286@1|root,COG1286@2|Bacteria,1NF4G@1224|Proteobacteria,1RQ58@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Colicin v production cvpA GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008152,GO:0009058,GO:0009403,GO:0009404,GO:0009987,GO:0016020,GO:0019748,GO:0044237,GO:0044249,GO:0044464,GO:0044550,GO:0071944 - ko:K03558 - - - - ko00000 - - - Colicin_V k59_1634518_1 887327.HMPREF0476_1185 3.51e-32 127.0 COG0506@1|root,COG4230@1|root,COG0506@2|Bacteria,COG4230@2|Bacteria,1MV93@1224|Proteobacteria,2VITK@28216|Betaproteobacteria,2KPMR@206351|Neisseriales 206351|Neisseriales C Oxidizes proline to glutamate for use as a carbon and nitrogen source putA - 1.2.1.88,1.5.5.2 ko:K13821 ko00250,ko00330,ko01100,ko01110,ko01130,map00250,map00330,map01100,map01110,map01130 - R00245,R00707,R00708,R01253,R04444,R04445,R05051 RC00080,RC00083,RC00216,RC00242,RC00255 ko00000,ko00001,ko01000,ko03000 - - - Aldedh,Pro_dh,Pro_dh-DNA_bdg k59_395003_1 1121921.KB898707_gene1207 4.25e-49 163.0 COG0074@1|root,COG0074@2|Bacteria,1MUGA@1224|Proteobacteria,1RM7Y@1236|Gammaproteobacteria,2PMRR@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria C CoA binding domain sucD GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009361,GO:0009987,GO:0016310,GO:0019538,GO:0032991,GO:0036211,GO:0042709,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0045239,GO:0046777,GO:0071704,GO:1901564,GO:1902494 6.2.1.5 ko:K01902 ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374,M00620 R00405,R02404 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000 - - iE2348C_1286.E2348C_0608 CoA_binding,Ligase_CoA k59_903241_1 1397527.Q670_01320 2.65e-74 234.0 COG1194@1|root,COG1194@2|Bacteria,1MUD4@1224|Proteobacteria,1RMBT@1236|Gammaproteobacteria,1XI99@135619|Oceanospirillales 135619|Oceanospirillales L glycosylase mutY - - ko:K03575 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - EndIII_4Fe-2S,HhH-GPD,NUDIX_4 k59_280317_1 314256.OG2516_12426 2.11e-44 155.0 COG0697@1|root,COG0697@2|Bacteria,1R46X@1224|Proteobacteria,2V8YR@28211|Alphaproteobacteria,2PFT4@252301|Oceanicola 28211|Alphaproteobacteria EG EamA-like transporter family - - - - - - - - - - - - EamA k59_280320_2 1379270.AUXF01000001_gene2507 6.81e-12 63.2 2FCBU@1|root,344FF@2|Bacteria,1ZU39@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - k59_280320_3 1379270.AUXF01000001_gene2089 2.4e-48 157.0 COG1694@1|root,COG1694@2|Bacteria 2|Bacteria FG Mazg nucleotide pyrophosphohydrolase ypjD - 2.5.1.19 ko:K00800 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R03460 RC00350 ko00000,ko00001,ko00002,ko01000 - - - MazG k59_110712_2 1123253.AUBD01000005_gene172 1.22e-11 66.6 COG0469@1|root,COG0469@2|Bacteria,1MU21@1224|Proteobacteria,1RMW3@1236|Gammaproteobacteria,1X3J7@135614|Xanthomonadales 135614|Xanthomonadales G Belongs to the pyruvate kinase family pykA - 2.7.1.40 ko:K00873 ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230 M00001,M00002,M00049,M00050 R00200,R00430,R01138,R01858,R02320 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - PK,PK_C k59_556976_1 1122137.AQXF01000003_gene2144 4.69e-61 207.0 COG1529@1|root,COG1529@2|Bacteria,1QTTJ@1224|Proteobacteria,2TQVK@28211|Alphaproteobacteria 28211|Alphaproteobacteria C COG1529 Aerobic-type carbon monoxide dehydrogenase large subunit CoxL CutL homologs MA20_34355 - 1.3.99.16 ko:K07303 - - - - ko00000,ko01000 - - - Ald_Xan_dh_C,Ald_Xan_dh_C2 k59_672135_2 570967.JMLV01000002_gene1550 5.59e-15 78.6 COG3243@1|root,COG3243@2|Bacteria,1Q6YK@1224|Proteobacteria,2TTVK@28211|Alphaproteobacteria,2JQPE@204441|Rhodospirillales 204441|Rhodospirillales I alpha/beta hydrolase fold - - - ko:K03821 ko00650,map00650 - R04254 RC00004 ko00000,ko00001,ko01000 - - - Abhydrolase_1,PhaC_N k59_1123877_1 228405.HNE_1610 2.38e-89 275.0 COG4948@1|root,COG4948@2|Bacteria,1MW76@1224|Proteobacteria,2TR16@28211|Alphaproteobacteria,43X6A@69657|Hyphomonadaceae 28211|Alphaproteobacteria M Belongs to the mandelate racemase muconate lactonizing enzyme family - GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016853,GO:0016854,GO:0034641,GO:0043167,GO:0043169,GO:0043603,GO:0044237,GO:0046872,GO:0071704,GO:1901564 5.1.1.20 ko:K19802 - - R10938 RC03309 ko00000,ko01000 - - - MR_MLE_C,MR_MLE_N k59_1123877_2 1122137.AQXF01000001_gene2603 7.67e-52 174.0 COG3367@1|root,COG3367@2|Bacteria,1MVEX@1224|Proteobacteria,2TS0Y@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Domain of unknown function (DUF1611_N) Rossmann-like domain - - - - - - - - - - - - DUF1611,DUF1611_N k59_903269_1 768671.ThimaDRAFT_3349 5.99e-96 291.0 COG0112@1|root,COG0112@2|Bacteria,1MUIS@1224|Proteobacteria,1RMHQ@1236|Gammaproteobacteria,1WW0I@135613|Chromatiales 135613|Chromatiales E Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism glyA - 2.1.2.1 ko:K00600 ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523 M00140,M00141,M00346,M00532 R00945,R09099 RC00022,RC00112,RC01583,RC02958 ko00000,ko00001,ko00002,ko01000 - - - SHMT k59_556980_1 1282361.ABAC402_09210 1.45e-07 53.5 COG2360@1|root,COG2360@2|Bacteria,1R9W8@1224|Proteobacteria,2U59K@28211|Alphaproteobacteria,2KG9S@204458|Caulobacterales 204458|Caulobacterales O Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine aat - 2.3.2.6 ko:K00684 - - R03813,R11443,R11444 RC00055,RC00064 ko00000,ko01000 - - - Leu_Phe_trans k59_556980_2 1046714.AMRX01000007_gene1898 2.63e-41 146.0 COG2935@1|root,COG2935@2|Bacteria,1MW62@1224|Proteobacteria,1RYD7@1236|Gammaproteobacteria,465QZ@72275|Alteromonadaceae 1236|Gammaproteobacteria O May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate ate GO:0003674,GO:0003824,GO:0004057,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006508,GO:0006511,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016598,GO:0016740,GO:0016746,GO:0016755,GO:0019538,GO:0019941,GO:0030163,GO:0036211,GO:0043170,GO:0043412,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044464,GO:0051603,GO:0071704,GO:0140096,GO:1901564,GO:1901565,GO:1901575 2.3.2.29 ko:K21420 - - R11547,R11548 RC00064 ko00000,ko01000 - - - ATE_C,ATE_N k59_1238380_1 1380391.JIAS01000011_gene5015 2.17e-10 62.0 COG2861@1|root,COG2861@2|Bacteria,1N3JP@1224|Proteobacteria,2TUFD@28211|Alphaproteobacteria,2JRXP@204441|Rhodospirillales 204441|Rhodospirillales S protein conserved in bacteria - - - ko:K09798 - - - - ko00000 - - - Polysacc_deac_2 k59_1238380_2 545694.TREPR_2445 1.01e-61 208.0 COG0187@1|root,COG0187@2|Bacteria,2J6PT@203691|Spirochaetes 203691|Spirochaetes L DNA topoisomerase parE - - ko:K02622 - - - - ko00000,ko01000,ko02048,ko03032,ko03036 - - - DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim k59_1123879_1 882082.SaccyDRAFT_3811 7.22e-78 251.0 COG4626@1|root,COG4626@2|Bacteria,2IB7D@201174|Actinobacteria,4E8SB@85010|Pseudonocardiales 201174|Actinobacteria S Terminase - - - - - - - - - - - - Terminase_1 k59_337990_1 587753.EY04_25925 2.97e-42 153.0 COG2271@1|root,COG2271@2|Bacteria,1NJTU@1224|Proteobacteria,1SN72@1236|Gammaproteobacteria 1236|Gammaproteobacteria G Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 k59_1238389_1 161156.JQKW01000011_gene914 2.3e-92 277.0 COG0081@1|root,COG0081@2|Bacteria,2GH9C@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria J Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release rplA - - ko:K02863 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L1 k59_1238389_2 999411.HMPREF1092_02435 9.31e-06 47.4 COG0244@1|root,COG0244@2|Bacteria,1V3JJ@1239|Firmicutes,24G9R@186801|Clostridia,36I5W@31979|Clostridiaceae 186801|Clostridia J Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors rplJ - - ko:K02864 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L10 k59_1746804_1 67267.JNXT01000054_gene2994 1.52e-27 117.0 COG3291@1|root,COG3291@2|Bacteria,2GJR2@201174|Actinobacteria 201174|Actinobacteria S Pkd domain containing protein - - - - - - - - - - - - CBM_4_9 k59_395055_2 861360.AARI_23030 8.91e-07 54.7 COG0454@1|root,COG0456@2|Bacteria,2IM9R@201174|Actinobacteria,1W9GP@1268|Micrococcaceae 201174|Actinobacteria K Ribosomal-protein-alanine acetyltransferase rimI GO:0003674,GO:0003824,GO:0004596,GO:0006464,GO:0006473,GO:0006474,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019538,GO:0031365,GO:0034212,GO:0036211,GO:0043170,GO:0043412,GO:0043543,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0051604,GO:0071704,GO:1901564 2.3.1.128 ko:K03789 - - - - ko00000,ko01000,ko03009 - - - Acetyltransf_1 k59_903313_2 436308.Nmar_1621 5.95e-14 70.5 COG2301@1|root,arCOG00760@2157|Archaea,41S6F@651137|Thaumarchaeota 651137|Thaumarchaeota G HpcH/HpaI aldolase/citrate lyase family - - 4.1.3.34 ko:K01644 ko02020,map02020 - R00362 RC00067,RC01118 ko00000,ko00001,ko01000 - - - HpcH_HpaI k59_54786_1 1122137.AQXF01000005_gene1356 2.17e-77 250.0 COG1450@1|root,COG1450@2|Bacteria,1MUUA@1224|Proteobacteria,2TT8A@28211|Alphaproteobacteria 28211|Alphaproteobacteria NU general secretion pathway protein D gspD - - ko:K02453 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - Secretin,Secretin_N k59_1462945_1 95619.PM1_0224380 1.13e-29 118.0 COG2010@1|root,COG4993@1|root,COG2010@2|Bacteria,COG4993@2|Bacteria,1MUQX@1224|Proteobacteria,1RN5D@1236|Gammaproteobacteria 1236|Gammaproteobacteria G Dehydrogenase - - 1.1.2.8,1.1.5.5,1.1.9.1 ko:K00114,ko:K17760,ko:K22473 ko00010,ko00625,ko01100,ko01110,ko01120,ko01130,map00010,map00625,map01100,map01110,map01120,map01130 - R05062,R05198,R05285,R09479 RC00087,RC00088,RC01039 ko00000,ko00001,ko01000 - - - Cytochrome_CBB3,PQQ,PQQ_2 k59_1799221_1 202698.XP_007383231.1 0.00014 51.2 COG5153@1|root,KOG4540@2759|Eukaryota,38GNK@33154|Opisthokonta,3NWX1@4751|Fungi,3UY47@5204|Basidiomycota,224TU@155619|Agaricomycetes,3H4EX@355688|Agaricomycetes incertae sedis 4751|Fungi IU Alpha beta-hydrolase ATG15 GO:0000322,GO:0000323,GO:0000324,GO:0000328,GO:0003674,GO:0003824,GO:0004620,GO:0004622,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005773,GO:0005775,GO:0005783,GO:0006508,GO:0006575,GO:0006624,GO:0006629,GO:0006638,GO:0006644,GO:0006650,GO:0006658,GO:0006660,GO:0006793,GO:0006796,GO:0006807,GO:0006914,GO:0006996,GO:0007032,GO:0008150,GO:0008152,GO:0009056,GO:0009395,GO:0009987,GO:0010256,GO:0010467,GO:0012505,GO:0016020,GO:0016021,GO:0016042,GO:0016043,GO:0016050,GO:0016236,GO:0016237,GO:0016298,GO:0016485,GO:0016787,GO:0016788,GO:0019538,GO:0019637,GO:0022411,GO:0030397,GO:0031224,GO:0031974,GO:0034496,GO:0034727,GO:0036257,GO:0042219,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044260,GO:0044267,GO:0044422,GO:0044424,GO:0044425,GO:0044437,GO:0044444,GO:0044446,GO:0044464,GO:0044804,GO:0046434,GO:0046461,GO:0046475,GO:0046486,GO:0046503,GO:0051604,GO:0052689,GO:0061024,GO:0061919,GO:0070013,GO:0071704,GO:0071840,GO:1901564,GO:1901565,GO:1901575 3.1.1.3 ko:K17900 ko00561,ko01100,ko04138,map00561,map01100,map04138 M00098 R02250,R02687 RC00020,RC00037,RC00041,RC00094 ko00000,ko00001,ko00002,ko01000,ko03029,ko04131 - - - Lipase_3 k59_1799221_2 1565129.JSFF01000004_gene3087 2.72e-120 349.0 COG0426@1|root,COG0426@2|Bacteria,1N2Y0@1224|Proteobacteria,1RNZ8@1236|Gammaproteobacteria,2QAXI@267890|Shewanellaceae 1236|Gammaproteobacteria C Metallo-beta-lactamase superfamily - - - - - - - - - - - - Lactamase_B k59_110736_1 745718.JADT01000021_gene2620 1.43e-123 372.0 COG0457@1|root,COG0457@2|Bacteria,4NFIY@976|Bacteroidetes,1HYA6@117743|Flavobacteriia 976|Bacteroidetes S PFAM Peptidase family M49 - - 3.4.14.4 ko:K01277 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M49 k59_1581827_1 316056.RPC_0806 0.000193 43.9 COG0223@1|root,COG0223@2|Bacteria,1MU4Q@1224|Proteobacteria,2TSWX@28211|Alphaproteobacteria,3JTIQ@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria J Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus fmt GO:0003674,GO:0003824,GO:0004479,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006413,GO:0006464,GO:0006518,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016741,GO:0016742,GO:0019538,GO:0019988,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036211,GO:0043043,GO:0043170,GO:0043412,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0046483,GO:0071704,GO:0071951,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 2.1.2.9 ko:K00604 ko00670,ko00970,map00670,map00970 - R03940 RC00026,RC00165 ko00000,ko00001,ko01000 - - - Formyl_trans_C,Formyl_trans_N k59_1581827_2 525904.Tter_0879 2.65e-75 236.0 COG0501@1|root,COG0501@2|Bacteria,2NP1V@2323|unclassified Bacteria 2|Bacteria O Belongs to the peptidase M48B family htpX GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 - ko:K03799 - M00743 - - ko00000,ko00002,ko01000,ko01002 - - - Peptidase_M48 k59_1349149_1 1219045.BV98_000193 2.9e-37 137.0 COG2960@1|root,COG2960@2|Bacteria,1R494@1224|Proteobacteria,2TTAS@28211|Alphaproteobacteria,2KE1K@204457|Sphingomonadales 204457|Sphingomonadales S Protein of unknown function (DUF1552) - - - - - - - - - - - - HXXSHH k59_1349149_2 1123256.KB907931_gene2786 3.46e-15 77.8 COG5297@1|root,COG5297@2|Bacteria,1MV16@1224|Proteobacteria 1224|Proteobacteria G Protein of unknown function (DUF1592) - - - - - - - - - - - - PSCyt3,PSD2,PSD3,PSD4,PSD5 k59_280360_1 1121355.KB903377_gene20 2.91e-63 219.0 COG0495@1|root,COG0495@2|Bacteria,2GJI1@201174|Actinobacteria,22JIZ@1653|Corynebacteriaceae 201174|Actinobacteria J Belongs to the class-I aminoacyl-tRNA synthetase family leuS GO:0003674,GO:0003824,GO:0004812,GO:0004823,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006429,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0030312,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.4 ko:K01869 ko00970,map00970 M00359,M00360 R03657 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - Anticodon_1,tRNA-synt_1,tRNA-synt_1_2 k59_672164_1 485918.Cpin_5298 2.89e-44 153.0 COG3161@1|root,COG3161@2|Bacteria 2|Bacteria H Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway ubiC GO:0003674,GO:0003824,GO:0006082,GO:0008150,GO:0008152,GO:0008813,GO:0009058,GO:0009273,GO:0009987,GO:0016043,GO:0016053,GO:0016829,GO:0016830,GO:0016833,GO:0019752,GO:0022607,GO:0032787,GO:0042546,GO:0043436,GO:0043648,GO:0044085,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046417,GO:0071554,GO:0071704,GO:0071766,GO:0071770,GO:0071840,GO:0072330,GO:1901576 4.1.3.40 ko:K03181 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00117 R01302 RC00491,RC02148 ko00000,ko00001,ko00002,ko01000 - - - DUF98 k59_851123_2 1121106.JQKB01000016_gene5355 8.67e-49 158.0 2AJ2R@1|root,319M2@2|Bacteria,1RJXB@1224|Proteobacteria,2UA6I@28211|Alphaproteobacteria,2JY06@204441|Rhodospirillales 204441|Rhodospirillales S Conserved hypothetical protein (Lin0512_fam) - - - - - - - - - - - - Lin0512_fam k59_624943_1 1336208.JADY01000026_gene2278 2.74e-33 125.0 COG5285@1|root,COG5285@2|Bacteria,1N31I@1224|Proteobacteria,2U12W@28211|Alphaproteobacteria,2JVKY@204441|Rhodospirillales 204441|Rhodospirillales Q Phytanoyl-CoA dioxygenase (PhyH) - - 1.14.11.46 ko:K21195 ko00440,map00440 - R10724 RC01107 ko00000,ko00001,ko01000 - - - PhyH k59_1020825_1 316407.4062584 2.51e-131 381.0 COG2837@1|root,COG2837@2|Bacteria,1MUEE@1224|Proteobacteria,1RNXN@1236|Gammaproteobacteria,3XMXM@561|Escherichia 1236|Gammaproteobacteria P Involved in the recovery of exogenous heme iron. Extracts iron from heme while preserving the tetrapyrrol ring intact ycdB - - ko:K16301 - - - - ko00000,ko01000,ko02000 2.A.108.2.3 - - Dyp_perox k59_3604_2 323848.Nmul_A2713 2.17e-42 143.0 COG2885@1|root,COG2885@2|Bacteria,1MZTV@1224|Proteobacteria,2VSP6@28216|Betaproteobacteria,3736X@32003|Nitrosomonadales 28216|Betaproteobacteria M Belongs to the ompA family pal - - ko:K03640 - - - - ko00000,ko02000 2.C.1.2 - - OmpA k59_681421_1 519989.ECTPHS_09403 1.47e-59 198.0 COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,1RN9T@1236|Gammaproteobacteria,1WX0Q@135613|Chromatiales 135613|Chromatiales O Belongs to the peptidase S1C family - - 3.4.21.107 ko:K04771,ko:K04772 ko01503,ko02020,map01503,map02020 M00728 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 - - - PDZ,PDZ_2,Trypsin_2 k59_342833_1 391616.OA238_c47510 6.94e-68 224.0 COG4666@1|root,COG4666@2|Bacteria,1MUNB@1224|Proteobacteria,2TQY9@28211|Alphaproteobacteria 1224|Proteobacteria S transport system fused permease components - - - - - - - - - - - - DctM k59_399135_1 1182553.XP_007750074.1 1.02e-06 53.1 2D48V@1|root,2SUA4@2759|Eukaryota,3ANTA@33154|Opisthokonta,3PEXF@4751|Fungi,3R45G@4890|Ascomycota,20P07@147545|Eurotiomycetes 4751|Fungi S SnoaL-like domain - - - - - - - - - - - - SnoaL_4 k59_851156_1 1123392.AQWL01000001_gene1438 8.58e-70 223.0 COG0276@1|root,COG0276@2|Bacteria,1MVR1@1224|Proteobacteria,2VH7Z@28216|Betaproteobacteria,1KRDW@119069|Hydrogenophilales 119069|Hydrogenophilales H Ferrochelatase - - 4.99.1.1,4.99.1.9 ko:K01772 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R00310,R11329 RC01012 ko00000,ko00001,ko00002,ko01000 - - - Ferrochelatase k59_851156_2 977880.RALTA_A1113 4.24e-13 68.2 COG1420@1|root,COG1420@2|Bacteria,1MVX4@1224|Proteobacteria,2VHCK@28216|Betaproteobacteria,1JZQY@119060|Burkholderiaceae 28216|Betaproteobacteria K Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons hrcA - - ko:K03705 - - - - ko00000,ko03000 - - - HrcA,HrcA_DNA-bdg k59_1698363_1 1217714.F975_02960 8.34e-33 125.0 COG0412@1|root,COG0412@2|Bacteria,1MW7S@1224|Proteobacteria,1S2MX@1236|Gammaproteobacteria,3NJXM@468|Moraxellaceae 1236|Gammaproteobacteria Q dienelactone hydrolase - - - - - - - - - - - - DLH,Peptidase_S9 k59_794710_1 686340.Metal_0749 9.73e-14 69.7 COG2360@1|root,COG2360@2|Bacteria,1R9W8@1224|Proteobacteria,1S1ZB@1236|Gammaproteobacteria,1XE78@135618|Methylococcales 135618|Methylococcales O Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine aat - 2.3.2.6 ko:K00684 - - R03813,R11443,R11444 RC00055,RC00064 ko00000,ko01000 - - - Leu_Phe_trans k59_794710_2 1304275.C41B8_01787 9.08e-40 132.0 COG0361@1|root,COG0361@2|Bacteria,1MZFU@1224|Proteobacteria,1S8WZ@1236|Gammaproteobacteria 1236|Gammaproteobacteria J One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex infA GO:0003674,GO:0003676,GO:0003723,GO:0003743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006413,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - ko:K02518 - - - - ko00000,ko03012 - - - eIF-1a k59_1472455_1 1449976.KALB_4527 2.42e-35 130.0 COG0500@1|root,COG2226@2|Bacteria,2GNJS@201174|Actinobacteria,4E1EP@85010|Pseudonocardiales 201174|Actinobacteria Q Hypothetical methyltransferase - - - - - - - - - - - - Methyltransf_11 k59_229453_1 864051.BurJ1DRAFT_2706 1.93e-17 80.5 COG0583@1|root,COG0583@2|Bacteria,1MV36@1224|Proteobacteria,2VID0@28216|Betaproteobacteria,1KKGV@119065|unclassified Burkholderiales 28216|Betaproteobacteria K LysR substrate binding domain - - - - - - - - - - - - HTH_1,LysR_substrate k59_229453_3 314275.MADE_1018520 4.14e-11 61.2 COG3295@1|root,COG3295@2|Bacteria,1RFI2@1224|Proteobacteria,1S50U@1236|Gammaproteobacteria,46ANB@72275|Alteromonadaceae 1236|Gammaproteobacteria S Protein conserved in bacteria - - - - - - - - - - - - PepSY_TM k59_1473337_1 1122223.KB890700_gene1962 2.1e-06 49.3 COG1173@1|root,COG1173@2|Bacteria,1WI67@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus EP ABC-type dipeptide oligopeptide nickel transport systems, permease components appC - - ko:K02034 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1,OppC_N k59_1473337_2 290397.Adeh_3119 1.64e-05 47.4 COG1653@1|root,COG1653@2|Bacteria,1MU64@1224|Proteobacteria,432JM@68525|delta/epsilon subdivisions,2WXPM@28221|Deltaproteobacteria 28221|Deltaproteobacteria G Extracellular solute-binding protein - - - ko:K02027 - M00207 - - ko00000,ko00002,ko02000 3.A.1.1 - - SBP_bac_8 k59_1360376_1 1121451.DESAM_10049 1.65e-29 120.0 COG1283@1|root,COG1283@2|Bacteria,1MUDE@1224|Proteobacteria,42PW9@68525|delta/epsilon subdivisions,2WJTI@28221|Deltaproteobacteria,2M9TB@213115|Desulfovibrionales 28221|Deltaproteobacteria P PFAM Na Pi-cotransporter - - - ko:K03324 - - - - ko00000,ko02000 2.A.58.2 - - Na_Pi_cotrans,PhoU k59_1529771_1 1122137.AQXF01000001_gene3215 9.39e-107 322.0 COG0168@1|root,COG0168@2|Bacteria,1MUIJ@1224|Proteobacteria,2TRPX@28211|Alphaproteobacteria 28211|Alphaproteobacteria P Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA trkH - - ko:K03498 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - - TrkH k59_739279_1 1197706.AKKK01000001_gene1822 3.79e-45 163.0 COG0644@1|root,COG1853@1|root,COG0644@2|Bacteria,COG1853@2|Bacteria,2GN9I@201174|Actinobacteria 201174|Actinobacteria C Flavin reductase like domain - - - - - - - - - - - - Flavin_Reduct k59_1416650_2 314278.NB231_15863 2.71e-20 91.7 COG0768@1|root,COG0768@2|Bacteria,1MV8C@1224|Proteobacteria,1RN9H@1236|Gammaproteobacteria,1WWAT@135613|Chromatiales 135613|Chromatiales M Catalyzes cross-linking of the peptidoglycan cell wall mrdA - 3.4.16.4 ko:K05515 ko00550,ko01501,map00550,map01501 - - - ko00000,ko00001,ko01000,ko01011 - - - PBP_dimer,Transpeptidase k59_117688_1 1229205.BUPH_03632 1.24e-144 422.0 COG0206@1|root,COG0206@2|Bacteria,1MV2X@1224|Proteobacteria,2VH0S@28216|Betaproteobacteria,1K1ET@119060|Burkholderiaceae 28216|Betaproteobacteria D Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity ftsZ - - ko:K03531 ko04112,map04112 - - - ko00000,ko00001,ko02048,ko03036,ko04812 - - - FtsZ_C,Tubulin k59_287277_2 207954.MED92_05603 1.78e-06 52.0 COG0594@1|root,COG0594@2|Bacteria,1MZQE@1224|Proteobacteria,1S90M@1236|Gammaproteobacteria,1XKHZ@135619|Oceanospirillales 135619|Oceanospirillales J RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme rnpA - 3.1.26.5 ko:K03536 - - - - ko00000,ko01000,ko03016 - - - Ribonuclease_P k59_61281_2 861299.J421_3665 2.02e-35 134.0 COG1164@1|root,COG1164@2|Bacteria,1ZTDD@142182|Gemmatimonadetes 142182|Gemmatimonadetes E Peptidase family M3 - - - ko:K08602 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M3 k59_287280_1 1307759.JOMJ01000004_gene2816 1.87e-44 160.0 COG0064@1|root,COG0064@2|Bacteria,1MUKG@1224|Proteobacteria,42M31@68525|delta/epsilon subdivisions,2WJK4@28221|Deltaproteobacteria,2M8VR@213115|Desulfovibrionales 28221|Deltaproteobacteria J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) gatB GO:0003674,GO:0003824,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564 6.3.5.6,6.3.5.7 ko:K02434 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - GatB_N,GatB_Yqey k59_230329_1 1120985.AUMI01000019_gene2286 3.89e-40 149.0 COG0541@1|root,COG0541@2|Bacteria,1TP06@1239|Firmicutes,4H29G@909932|Negativicutes 909932|Negativicutes U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY ffh - 3.6.5.4 ko:K03106 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko01000,ko02044 3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9 - - SRP54,SRP54_N,SRP_SPB k59_851996_1 279238.Saro_3437 4.25e-82 271.0 COG4774@1|root,COG4774@2|Bacteria,1R5EH@1224|Proteobacteria,2U458@28211|Alphaproteobacteria,2K054@204457|Sphingomonadales 204457|Sphingomonadales P TonB dependent receptor - - - - - - - - - - - - Plug,TonB_dep_Rec k59_343731_1 391625.PPSIR1_29598 1.76e-68 225.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,2YU4Y@29|Myxococcales 28221|Deltaproteobacteria T Two component, sigma54 specific, transcriptional regulator, Fis family - - - ko:K07712 ko02020,map02020 M00497 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_964854_1 402777.KB235903_gene663 0.000175 48.9 COG2755@1|root,COG2755@2|Bacteria,1G060@1117|Cyanobacteria,1H9JP@1150|Oscillatoriales 1117|Cyanobacteria E GDSL-like Lipase/Acylhydrolase - - - - - - - - - - - - Lipase_GDSL k59_1190999_1 1163409.UUA_03016 1.64e-40 147.0 COG1749@1|root,COG1749@2|Bacteria,1MU5J@1224|Proteobacteria,1RMWX@1236|Gammaproteobacteria,1X2YC@135614|Xanthomonadales 135614|Xanthomonadales N Flagellar hook protein FlgE flgE - - ko:K02390 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - FlaE,Flg_bb_rod,Flg_bbr_C k59_1190999_2 379731.PST_1390 3.83e-21 91.3 COG1843@1|root,COG1843@2|Bacteria,1MXCG@1224|Proteobacteria,1RPZI@1236|Gammaproteobacteria,1Z1KF@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria N Required for flagellar hook formation. May act as a scaffolding protein flgD - - ko:K02389 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - FLgD_tudor,FlgD,FlgD_ig k59_739303_1 1121013.P873_12390 1.69e-88 272.0 COG1820@1|root,COG1820@2|Bacteria,1QUJ0@1224|Proteobacteria,1T26K@1236|Gammaproteobacteria 1236|Gammaproteobacteria E Catalyzes the hydrolytic cleavage of a subset of L- isoaspartyl (L-beta-aspartyl) dipeptides. Used to degrade proteins damaged by L-isoaspartyl residues formation iadA GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0008242,GO:0008270,GO:0008798,GO:0016787,GO:0019538,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0070011,GO:0071704,GO:0140096,GO:1901564 - ko:K01305 - - - - ko00000,ko01000,ko01002 - - - Amidohydro_1,Amidohydro_3 k59_852011_1 715451.ambt_17955 1.69e-70 228.0 COG3177@1|root,COG3177@2|Bacteria,1MX0V@1224|Proteobacteria,1RQYT@1236|Gammaproteobacteria,465WD@72275|Alteromonadaceae 1236|Gammaproteobacteria S Filamentation induced by cAMP protein fic - - - - - - - - - - - - Fic k59_852011_2 76636.JOEC01000001_gene1022 3.24e-26 107.0 COG0553@1|root,COG0553@2|Bacteria,2GISC@201174|Actinobacteria,4FKDC@85023|Microbacteriaceae 201174|Actinobacteria L SNF2 family N-terminal domain helZ - - - - - - - - - - - Helicase_C,SNF2_N,SNF2_assoc,SWIM k59_795570_1 360910.BAV1512 1.35e-168 495.0 COG0443@1|root,COG0443@2|Bacteria,1MVQI@1224|Proteobacteria,2VHGV@28216|Betaproteobacteria,3T1C3@506|Alcaligenaceae 28216|Betaproteobacteria O Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB hscA GO:0000166,GO:0000988,GO:0000989,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008144,GO:0008150,GO:0008270,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010033,GO:0010556,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0016989,GO:0017076,GO:0017111,GO:0019219,GO:0019222,GO:0022607,GO:0030554,GO:0031323,GO:0031326,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033554,GO:0034620,GO:0035639,GO:0035966,GO:0035967,GO:0036094,GO:0042221,GO:0043167,GO:0043168,GO:0043169,GO:0043531,GO:0043933,GO:0044085,GO:0044183,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0051171,GO:0051252,GO:0051716,GO:0060255,GO:0061077,GO:0065003,GO:0065007,GO:0070887,GO:0071310,GO:0071840,GO:0080090,GO:0097159,GO:0097367,GO:0140110,GO:1901265,GO:1901363,GO:1903506,GO:2001141 - ko:K04044 - - - - ko00000,ko03110 1.A.33 - - HSP70 k59_1755780_1 443143.GM18_4033 2.41e-28 117.0 COG1729@1|root,COG1729@2|Bacteria,1MX82@1224|Proteobacteria,42TQ9@68525|delta/epsilon subdivisions,2WR3B@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Tetratricopeptide repeat - - - - - - - - - - - - TPR_16,TPR_6 k59_61304_1 1323663.AROI01000020_gene780 4.04e-94 286.0 COG0683@1|root,COG0683@2|Bacteria,1MU8V@1224|Proteobacteria,1RMIJ@1236|Gammaproteobacteria 1236|Gammaproteobacteria E COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component - - - ko:K11959 ko02010,map02010 M00323 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4.4,3.A.1.4.5 - - Peripla_BP_5 k59_1699299_1 1392498.JQLH01000001_gene1963 1.61e-69 225.0 COG0526@1|root,COG0526@2|Bacteria,4NK8N@976|Bacteroidetes,1I84U@117743|Flavobacteriia,2PHWD@252356|Maribacter 976|Bacteroidetes CO Thioredoxin-like - - - - - - - - - - - - Thioredoxin_8 k59_174206_2 999541.bgla_1g10490 5.68e-06 47.4 COG0695@1|root,COG0695@2|Bacteria,1N82H@1224|Proteobacteria,2VWG7@28216|Betaproteobacteria,1K9F5@119060|Burkholderiaceae 28216|Betaproteobacteria O PFAM glutaredoxin 2 - - - - - - - - - - - - DUF836 k59_230352_1 158500.BV97_02732 1.26e-114 342.0 COG0661@1|root,COG0661@2|Bacteria,1MU1Z@1224|Proteobacteria,2TS87@28211|Alphaproteobacteria,2K1BA@204457|Sphingomonadales 204457|Sphingomonadales S Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis ubiB - - ko:K03688 - - - - ko00000 - - - ABC1 k59_400001_1 1297742.A176_00963 7.9e-71 241.0 COG0514@1|root,COG0550@1|root,COG0514@2|Bacteria,COG0550@2|Bacteria,1MUFZ@1224|Proteobacteria,42NQG@68525|delta/epsilon subdivisions,2WJXC@28221|Deltaproteobacteria,2YU8A@29|Myxococcales 28221|Deltaproteobacteria L ATP-dependent DNA helicase RecQ topB - 5.99.1.2 ko:K03169 - - - - ko00000,ko01000,ko03032 - - - DEAD,HRDC,Helicase_C,RecQ_Zn_bind,Topoisom_bac,Toprim,Toprim_Crpt,zf-C4_Topoisom k59_400001_2 1299327.I546_6847 3.15e-68 219.0 COG0685@1|root,COG0685@2|Bacteria,2GM4R@201174|Actinobacteria,235HA@1762|Mycobacteriaceae 201174|Actinobacteria E methylenetetrahydrofolate reductase (NAD(P)H) activity - - - - - - - - - - - - - k59_1303933_1 1408224.SAMCCGM7_c5932 1.58e-89 272.0 COG1028@1|root,COG1028@2|Bacteria,1MUBQ@1224|Proteobacteria,2TRPN@28211|Alphaproteobacteria,4B9QX@82115|Rhizobiaceae 28211|Alphaproteobacteria IQ Belongs to the short-chain dehydrogenases reductases (SDR) family - - - - - - - - - - - - adh_short k59_625861_1 631454.N177_0480 5.03e-81 253.0 COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,2TQQ7@28211|Alphaproteobacteria,1JNB8@119043|Rhodobiaceae 28211|Alphaproteobacteria I Thiolase, N-terminal domain - - 2.3.1.16,2.3.1.174 ko:K00632,ko:K07823 ko00071,ko00280,ko00281,ko00362,ko00592,ko00642,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00362,map00592,map00642,map01100,map01110,map01120,map01130,map01212 M00087,M00113 R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095 RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955 ko00000,ko00001,ko00002,ko01000 - - - Thiolase_C,Thiolase_N k59_230368_1 702113.PP1Y_AT33760 3.95e-42 145.0 2C0PG@1|root,330E3@2|Bacteria,1RA6M@1224|Proteobacteria,2U5UJ@28211|Alphaproteobacteria,2K3P1@204457|Sphingomonadales 204457|Sphingomonadales S Domain of unknown function (DUF4136) - - - - - - - - - - - - DUF4136 k59_230368_2 1207055.C100_21365 1.65e-06 49.3 COG2258@1|root,COG2258@2|Bacteria,1RAPM@1224|Proteobacteria,2U5IG@28211|Alphaproteobacteria,2K3XH@204457|Sphingomonadales 204457|Sphingomonadales S protein conserved in bacteria - - - - - - - - - - - - 3-alpha,MOSC k59_230369_1 391603.FBALC1_01057 1.12e-101 304.0 COG0330@1|root,COG0330@2|Bacteria,4NFPK@976|Bacteroidetes,1HZJ2@117743|Flavobacteriia 976|Bacteroidetes O prohibitin homologues - - - - - - - - - - - - Band_7 k59_117713_1 1415778.JQMM01000001_gene85 8.66e-66 213.0 COG0330@1|root,COG0330@2|Bacteria,1MUM2@1224|Proteobacteria,1RMUG@1236|Gammaproteobacteria,1J4H5@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O HflC and HflK could encode or regulate a protease hflK GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006508,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008233,GO:0009266,GO:0009408,GO:0009628,GO:0009897,GO:0009986,GO:0016020,GO:0016021,GO:0016787,GO:0019538,GO:0031224,GO:0031226,GO:0031233,GO:0032991,GO:0043086,GO:0043170,GO:0044092,GO:0044238,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0050790,GO:0050896,GO:0065007,GO:0065009,GO:0071575,GO:0071704,GO:0071944,GO:0098552,GO:0098796,GO:0140096,GO:1901564 - ko:K04088 - M00742 - - ko00000,ko00002,ko01000 - - - Band_7,HflK_N k59_287326_1 187272.Mlg_0270 1.86e-48 172.0 COG0508@1|root,COG0508@2|Bacteria,1MU7K@1224|Proteobacteria,1RNPT@1236|Gammaproteobacteria,1WW8D@135613|Chromatiales 135613|Chromatiales C The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) - - 2.3.1.12 ko:K00627 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200 M00307 R00209,R02569 RC00004,RC02742,RC02857 br01601,ko00000,ko00001,ko00002,ko01000 - - - 2-oxoacid_dh,Biotin_lipoyl,E3_binding k59_117726_1 469618.FVAG_01191 0.000354 48.1 COG0728@1|root,COG0728@2|Bacteria,3789R@32066|Fusobacteria 32066|Fusobacteria S Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane murJ - - ko:K03980 - - - - ko00000,ko01011,ko02000 2.A.66.4 - - MVIN k59_1134453_1 316407.1742495 3.31e-115 342.0 COG0246@1|root,COG0246@2|Bacteria,1MVZ7@1224|Proteobacteria,1RQX5@1236|Gammaproteobacteria,3XM9T@561|Escherichia 1236|Gammaproteobacteria G Belongs to the mannitol dehydrogenase family. UxaB subfamily uxaB GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006063,GO:0006082,GO:0008150,GO:0008152,GO:0009026,GO:0009056,GO:0009987,GO:0016052,GO:0016054,GO:0016491,GO:0016614,GO:0016616,GO:0019586,GO:0019698,GO:0019752,GO:0032787,GO:0036094,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046395,GO:0046396,GO:0046397,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0071704,GO:0072329,GO:0097159,GO:1901265,GO:1901363,GO:1901575 1.1.1.57,1.1.1.58 ko:K00040,ko:K00041 ko00040,ko01100,map00040,map01100 M00061,M00631 R02454,R02555 RC00085 ko00000,ko00001,ko00002,ko01000 - - iECABU_c1320.ECABU_c17480 Mannitol_dh,Mannitol_dh_C k59_908300_1 1122137.AQXF01000001_gene2731 1.89e-107 331.0 COG4206@1|root,COG4206@2|Bacteria,1R1WX@1224|Proteobacteria,2U0GK@28211|Alphaproteobacteria 28211|Alphaproteobacteria H receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_852051_1 1144307.PMI04_00265 4.65e-105 329.0 COG1629@1|root,COG4206@1|root,COG1629@2|Bacteria,COG4206@2|Bacteria,1QUTB@1224|Proteobacteria,2U1JX@28211|Alphaproteobacteria,2K27N@204457|Sphingomonadales 204457|Sphingomonadales HP Outer membrane protein beta-barrel family - - - - - - - - - - - - Plug,TonB_dep_Rec k59_1134461_1 1115515.EV102420_07_03130 1.43e-53 179.0 COG0451@1|root,COG0451@2|Bacteria,1MX2J@1224|Proteobacteria,1RPHW@1236|Gammaproteobacteria,3XMKU@561|Escherichia 1236|Gammaproteobacteria M Polysaccharide biosynthesis protein gne GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009987,GO:0016020,GO:0016051,GO:0016853,GO:0016854,GO:0016857,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 1.1.1.219,5.1.3.26 ko:K00091,ko:K19997 - - - - ko00000,ko01000 - - - 3Beta_HSD,Epimerase k59_287335_1 436308.Nmar_1177 6.89e-91 283.0 COG1164@1|root,arCOG04758@2157|Archaea,41S7J@651137|Thaumarchaeota 651137|Thaumarchaeota E Peptidase family M3 - - - ko:K08602 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M3,Peptidase_M3_N k59_964917_1 1123257.AUFV01000017_gene3753 5.67e-64 210.0 COG0770@1|root,COG0770@2|Bacteria,1QTSF@1224|Proteobacteria,1RMGD@1236|Gammaproteobacteria,1X3IV@135614|Xanthomonadales 135614|Xanthomonadales M Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein murF - 6.3.2.10 ko:K01929 ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502 - R04573,R04617 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_512886_1 313612.L8106_03969 1.21e-14 77.0 COG0154@1|root,COG0154@2|Bacteria,1G1MZ@1117|Cyanobacteria,1H98Z@1150|Oscillatoriales 1117|Cyanobacteria J Belongs to the amidase family nylA - 3.5.1.4 ko:K01426 ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120 - R02540,R03096,R03180,R03909,R05551,R05590 RC00010,RC00100,RC00950,RC01025 ko00000,ko00001,ko01000 - - iJN678.nylA Amidase k59_852061_1 1211112.ALJC01000137_gene426 5.3e-50 174.0 COG2801@1|root,COG2801@2|Bacteria,1N207@1224|Proteobacteria,1S1FB@1236|Gammaproteobacteria 1236|Gammaproteobacteria L COG2801 Transposase and inactivated derivatives - - - - - - - - - - - - HTH_28,HTH_32,LZ_Tnp_IS481,rve,rve_3 k59_4624_1 1122137.AQXF01000005_gene1262 3.6e-226 650.0 COG4770@1|root,COG4770@2|Bacteria,1P6RE@1224|Proteobacteria,2TRC2@28211|Alphaproteobacteria 28211|Alphaproteobacteria I Acetyl propionyl-CoA carboxylase alpha subunit MA20_30205 - 6.4.1.4 ko:K01968 ko00280,ko01100,map00280,map01100 M00036 R04138 RC00367,RC00942 ko00000,ko00001,ko00002,ko01000 - - - Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2 k59_852069_1 487316.BBNM01000004_gene582 6.57e-75 234.0 COG0022@1|root,COG0022@2|Bacteria,1R8KB@1224|Proteobacteria,1RP3G@1236|Gammaproteobacteria,3NKUU@468|Moraxellaceae 1236|Gammaproteobacteria C Transketolase, C-terminal domain acoB - - ko:K21417 - - - - ko00000,ko01000 - - - Transket_pyr,Transketolase_C k59_1303974_1 1071679.BG57_21315 3.65e-88 270.0 COG0482@1|root,COG0482@2|Bacteria,1MUT1@1224|Proteobacteria,2VJRR@28216|Betaproteobacteria,1K159@119060|Burkholderiaceae 28216|Betaproteobacteria J Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 mnmA - 2.8.1.13 ko:K00566 ko04122,map04122 - R08700 RC02313,RC02315 ko00000,ko00001,ko01000,ko03016 - - - tRNA_Me_trans k59_625934_1 248742.XP_005651025.1 2.03e-98 300.0 COG0626@1|root,KOG0053@2759|Eukaryota,37RGY@33090|Viridiplantae,34JAR@3041|Chlorophyta 3041|Chlorophyta E Cys/Met metabolism PLP-dependent enzyme - - 4.4.1.11 ko:K01761 ko00270,ko00450,map00270,map00450 - R00654,R04770 RC00196,RC00348,RC01209,RC01210 ko00000,ko00001,ko01000 - - - Cys_Met_Meta_PP k59_287362_1 519989.ECTPHS_06357 2.43e-29 122.0 COG3206@1|root,COG3206@2|Bacteria,1MVBX@1224|Proteobacteria,1RXY8@1236|Gammaproteobacteria,1WWGP@135613|Chromatiales 135613|Chromatiales M Polysaccharide chain length determinant protein - - - - - - - - - - - - GNVR,Wzz k59_230431_1 1452718.JBOY01000021_gene727 2.61e-08 58.5 COG0237@1|root,COG0237@2|Bacteria 2|Bacteria H dephospho-CoA kinase activity - - 2.7.1.24 ko:K00859 ko00770,ko01100,map00770,map01100 M00120 R00130 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - AAA_18 k59_1473461_1 1415778.JQMM01000001_gene1809 1.14e-55 176.0 COG2009@1|root,COG2009@2|Bacteria,1RIGZ@1224|Proteobacteria,1S5ZE@1236|Gammaproteobacteria,1J6QM@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C COG2009 Succinate dehydrogenase fumarate reductase, cytochrome b subunit sdhC GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K00241 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00149,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002 - - - Sdh_cyt k59_1473461_2 498211.CJA_1502 3.34e-44 147.0 COG2142@1|root,COG2142@2|Bacteria,1MZR9@1224|Proteobacteria,1S9TS@1236|Gammaproteobacteria,1FHCS@10|Cellvibrio 1236|Gammaproteobacteria C Membrane-anchoring subunit of succinate dehydrogenase (SDH) sdhD GO:0000104,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009055,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016043,GO:0016491,GO:0016627,GO:0016999,GO:0017004,GO:0017144,GO:0019752,GO:0020037,GO:0022607,GO:0022900,GO:0032991,GO:0034622,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0045273,GO:0045274,GO:0045281,GO:0045282,GO:0045333,GO:0046906,GO:0048037,GO:0055114,GO:0065003,GO:0070469,GO:0070470,GO:0071704,GO:0071840,GO:0071944,GO:0072350,GO:0097159,GO:0098796,GO:0098797,GO:0098803,GO:1901363,GO:1902494,GO:1990204 - ko:K00242 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00149,M00173 R02164 RC00045 ko00000,ko00001,ko00002 - - e_coli_core.b0722,iAF1260.b0722,iAPECO1_1312.APECO1_1356,iB21_1397.B21_00671,iBWG_1329.BWG_0581,iE2348C_1286.E2348C_0602,iEC042_1314.EC042_0740,iECABU_c1320.ECABU_c07680,iECBD_1354.ECBD_2938,iECB_1328.ECB_00682,iECDH10B_1368.ECDH10B_0789,iECDH1ME8569_1439.ECDH1ME8569_0681,iECD_1391.ECD_00682,iECED1_1282.ECED1_0692,iECIAI1_1343.ECIAI1_0696,iECIAI39_1322.ECIAI39_0680,iECNA114_1301.ECNA114_0658,iECO103_1326.ECO103_0716,iECO111_1330.ECO111_0739,iECO26_1355.ECO26_0783,iECOK1_1307.ECOK1_0722,iECP_1309.ECP_0734,iECS88_1305.ECS88_0748,iECSE_1348.ECSE_0782,iECSF_1327.ECSF_0655,iECUMN_1333.ECUMN_0800,iECW_1372.ECW_m0777,iEKO11_1354.EKO11_3157,iETEC_1333.ETEC_0733,iEcDH1_1363.EcDH1_2913,iEcE24377_1341.EcE24377A_0749,iEcHS_1320.EcHS_A0770,iEcSMS35_1347.EcSMS35_0735,iEcolC_1368.EcolC_2933,iJO1366.b0722,iJR904.b0722,iLF82_1304.LF82_2100,iNRG857_1313.NRG857_03215,iSBO_1134.SBO_0580,iSDY_1059.SDY_0660,iSFV_1184.SFV_0613,iSF_1195.SF0575,iSFxv_1172.SFxv_0634,iSSON_1240.SSON_0673,iS_1188.S0588,iUMN146_1321.UM146_14010,iUMNK88_1353.UMNK88_758,iUTI89_1310.UTI89_C0718,iWFL_1372.ECW_m0777,iY75_1357.Y75_RS03755,ic_1306.c0800 Sdh_cyt k59_1473461_3 1415778.JQMM01000001_gene1807 1.38e-196 558.0 COG1053@1|root,COG1053@2|Bacteria,1MU5M@1224|Proteobacteria,1RMU2@1236|Gammaproteobacteria,1J4I0@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Belongs to the FAD-dependent oxidoreductase 2 family. FRD SDH subfamily sdhA GO:0000104,GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009055,GO:0009060,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016627,GO:0016999,GO:0017144,GO:0019752,GO:0022900,GO:0032991,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0045273,GO:0045274,GO:0045281,GO:0045282,GO:0045333,GO:0048037,GO:0050660,GO:0050662,GO:0055114,GO:0070469,GO:0070470,GO:0071704,GO:0071944,GO:0072350,GO:0097159,GO:0098796,GO:0098797,GO:0098803,GO:1901265,GO:1901363,GO:1902494,GO:1990204 1.3.5.1,1.3.5.4 ko:K00239 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134 M00009,M00011,M00149,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 - - iE2348C_1286.E2348C_0603,iJN746.PP_4191,iPC815.YPO1111 FAD_binding_2,Succ_DH_flav_C k59_625939_1 1122137.AQXF01000005_gene1202 8.04e-53 181.0 COG3845@1|root,COG3845@2|Bacteria,1NT0H@1224|Proteobacteria,2UPJ8@28211|Alphaproteobacteria 28211|Alphaproteobacteria S ABC transporter yufO - 3.6.3.17 ko:K02056 - M00221 - - ko00000,ko00002,ko01000,ko02000 3.A.1.2 - - ABC_tran k59_625939_2 1122137.AQXF01000005_gene1203 1.16e-156 446.0 COG1744@1|root,COG1744@2|Bacteria,1NGHH@1224|Proteobacteria,2TR36@28211|Alphaproteobacteria 28211|Alphaproteobacteria S ABC-type transport system, periplasmic component surface lipoprotein tmpC - - ko:K07335 - - - - ko00000 - - - Bmp k59_1021928_1 1288494.EBAPG3_21990 6.93e-47 171.0 COG0493@1|root,COG0543@1|root,COG0493@2|Bacteria,COG0543@2|Bacteria,1PV5D@1224|Proteobacteria,2WB3J@28216|Betaproteobacteria,37281@32003|Nitrosomonadales 28216|Betaproteobacteria CEH PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase - - - - - - - - - - - - Pyr_redox_2 k59_400092_1 1123020.AUIE01000011_gene1293 1.44e-37 145.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1YIWT@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria T Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - - - - - - - - - - EAL,GAF,GAF_2,GGDEF,MASE3,PAS,PAS_3,PAS_4,PAS_9,Response_reg k59_852087_1 876044.IMCC3088_1280 4.63e-108 324.0 COG0448@1|root,COG0448@2|Bacteria,1MVTC@1224|Proteobacteria,1RP04@1236|Gammaproteobacteria,1J9TH@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans glgC - 2.7.7.27 ko:K00975 ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026 M00565 R00948 RC00002 ko00000,ko00001,ko00002,ko01000 - - - NTP_transferase k59_1134495_1 452662.SJA_C1-21120 7.6e-40 152.0 COG1629@1|root,COG4774@1|root,COG1629@2|Bacteria,COG4774@2|Bacteria,1NMCN@1224|Proteobacteria 1224|Proteobacteria P COG1629 Outer membrane receptor proteins, mostly Fe transport - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_61385_1 702113.PP1Y_Mpl579 2.71e-17 80.5 COG1609@1|root,COG1609@2|Bacteria,1MUEP@1224|Proteobacteria,2U7WF@28211|Alphaproteobacteria,2K2KB@204457|Sphingomonadales 204457|Sphingomonadales K helix_turn _helix lactose operon repressor - - - ko:K06145 - - - - ko00000,ko03000 - - - LacI,Peripla_BP_3 k59_61385_2 279238.Saro_3405 5.62e-99 296.0 2BU8Z@1|root,32PIG@2|Bacteria,1NUGX@1224|Proteobacteria,2US41@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - OmpA k59_61385_3 279238.Saro_3404 4.01e-162 468.0 COG1858@1|root,COG1858@2|Bacteria,1REQ9@1224|Proteobacteria,2U8Q0@28211|Alphaproteobacteria 28211|Alphaproteobacteria C cytochrome C peroxidase - - - - - - - - - - - - - k59_569596_1 1121875.KB907556_gene615 4.84e-52 184.0 COG3264@1|root,COG3264@2|Bacteria,4NEAM@976|Bacteroidetes,1HYUA@117743|Flavobacteriia 976|Bacteroidetes M mechanosensitive ion channel - - - - - - - - - - - - MS_channel k59_739401_1 316407.1742738 1.82e-89 273.0 COG3468@1|root,COG3468@2|Bacteria,1NQVP@1224|Proteobacteria,1SMRB@1236|Gammaproteobacteria,3XNU0@561|Escherichia 1236|Gammaproteobacteria MU cellular response to DNA damage stimulus ydhQ GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0033554,GO:0050896,GO:0051716 - - - - - - - - - - AIDA,Pertactin k59_739401_2 316407.1742737 4.28e-61 199.0 COG0534@1|root,COG0534@2|Bacteria,1MUAM@1224|Proteobacteria,1RP5M@1236|Gammaproteobacteria,3XMVX@561|Escherichia 1236|Gammaproteobacteria P Multidrug efflux pump that functions probably as a Na( ) drug antiporter mdtK GO:0000302,GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006855,GO:0006857,GO:0006950,GO:0006979,GO:0008150,GO:0009987,GO:0015238,GO:0015833,GO:0015893,GO:0016020,GO:0022857,GO:0033554,GO:0034599,GO:0034614,GO:0035442,GO:0035672,GO:0035673,GO:0042221,GO:0042493,GO:0042886,GO:0042887,GO:0042891,GO:0042895,GO:0042938,GO:0044464,GO:0046677,GO:0050896,GO:0051179,GO:0051234,GO:0051716,GO:0055085,GO:0070887,GO:0071702,GO:0071705,GO:0071916,GO:0071944,GO:1901700,GO:1901701,GO:1904680 - ko:K03327 - - - - ko00000,ko02000 2.A.66.1 - - MatE k59_859724_2 351348.Maqu_2413 1.94e-33 129.0 COG0768@1|root,COG0768@2|Bacteria,1MV8C@1224|Proteobacteria,1RN9H@1236|Gammaproteobacteria,464KX@72275|Alteromonadaceae 1236|Gammaproteobacteria M Catalyzes cross-linking of the peptidoglycan cell wall mrdA GO:0000270,GO:0003674,GO:0003824,GO:0004180,GO:0004185,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006022,GO:0006023,GO:0006024,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0008238,GO:0008360,GO:0008658,GO:0009002,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016021,GO:0016043,GO:0016787,GO:0017171,GO:0019538,GO:0022603,GO:0022604,GO:0030203,GO:0031224,GO:0031226,GO:0031406,GO:0033218,GO:0033293,GO:0034645,GO:0036094,GO:0042221,GO:0042493,GO:0042546,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044425,GO:0044459,GO:0044464,GO:0045229,GO:0046677,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051128,GO:0065007,GO:0065008,GO:0070008,GO:0070011,GO:0070589,GO:0071554,GO:0071555,GO:0071704,GO:0071840,GO:0071944,GO:0071972,GO:0097159,GO:0140096,GO:1901135,GO:1901137,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901681 3.4.16.4 ko:K05515 ko00550,ko01501,map00550,map01501 - - - ko00000,ko00001,ko01000,ko01011 - - iEcE24377_1341.EcE24377A_0661,iPC815.YPO2604 PBP_dimer,Transpeptidase k59_407065_1 1232436.CAPF01000016_gene620 1.91e-08 64.3 COG0658@1|root,COG2333@1|root,COG0658@2|Bacteria,COG2333@2|Bacteria,2GJGR@201174|Actinobacteria,4CUJ1@84998|Coriobacteriia 84998|Coriobacteriia S competence protein ComEC - - - ko:K02238 - M00429 - - ko00000,ko00002,ko02044 3.A.11.1,3.A.11.2 - - Competence,Lactamase_B k59_124904_1 1254432.SCE1572_24855 4.17e-61 200.0 COG0714@1|root,COG0714@2|Bacteria,1MV5I@1224|Proteobacteria,42MTW@68525|delta/epsilon subdivisions,2WJ0J@28221|Deltaproteobacteria,2YUI8@29|Myxococcales 1224|Proteobacteria S ATPase family associated with various cellular activities (AAA) - - - - - - - - - - - - AAA,AAA_5 k59_1538605_4 1122137.AQXF01000001_gene2821 1.02e-63 197.0 COG0848@1|root,COG0848@2|Bacteria,1RI4M@1224|Proteobacteria,2VG9Y@28211|Alphaproteobacteria 28211|Alphaproteobacteria U Biopolymer transport protein ExbD/TolR - - - ko:K03559 - - - - ko00000,ko02000 1.A.30.2.1 - - ExbD k59_1538605_5 1122137.AQXF01000001_gene2822 5.1e-05 45.1 COG0810@1|root,COG0810@2|Bacteria,1PEDH@1224|Proteobacteria,2UEEK@28211|Alphaproteobacteria 28211|Alphaproteobacteria M Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins - - - ko:K03832 - - - - ko00000,ko02000 2.C.1.1 - - TonB_C k59_916729_2 1123401.JHYQ01000012_gene2825 2e-153 449.0 COG0486@1|root,COG0486@2|Bacteria,1MUCQ@1224|Proteobacteria,1RN5S@1236|Gammaproteobacteria,45ZQ5@72273|Thiotrichales 72273|Thiotrichales J Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 mnmE - - ko:K03650 - - R08701 RC00053,RC00209,RC00870 ko00000,ko01000,ko03016 - - - MMR_HSR1,MnmE_helical,TrmE_N k59_1086051_1 1424334.W822_22580 2.3e-30 123.0 COG4993@1|root,COG4993@2|Bacteria,1MUQX@1224|Proteobacteria,2VHVH@28216|Betaproteobacteria 28216|Betaproteobacteria G TIGRFAM PQQ-dependent dehydrogenase, methanol ethanol family - - 1.1.2.8 ko:K00114 ko00010,ko00625,ko01100,ko01110,ko01120,ko01130,map00010,map00625,map01100,map01110,map01120,map01130 - R05062,R05198,R05285 RC00087,RC00088,RC01039 ko00000,ko00001,ko01000 - - - PQQ,PQQ_2,PQQ_3 k59_1255692_1 373994.Riv7116_1660 7.81e-75 240.0 COG0687@1|root,COG0687@2|Bacteria,1GGXX@1117|Cyanobacteria 1117|Cyanobacteria E Bacterial extracellular solute-binding protein - - - ko:K02055 ko02024,map02024 M00193 - - ko00000,ko00001,ko00002,ko02000 3.A.1.11 - - SBP_bac_6 k59_804325_1 999415.HMPREF9943_00933 2.02e-38 140.0 COG0410@1|root,COG0410@2|Bacteria,1TPW4@1239|Firmicutes,3VP43@526524|Erysipelotrichia 526524|Erysipelotrichia E Psort location CytoplasmicMembrane, score - - - - - - - - - - - - ABC_tran,BCA_ABC_TP_C k59_1651515_1 109760.SPPG_07031T0 1.18e-71 245.0 COG1506@1|root,KOG2100@2759|Eukaryota,39CYF@33154|Opisthokonta,3NW9P@4751|Fungi 4751|Fungi O dipeptidylpeptidase dpp5 GO:0003674,GO:0003824,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0016787,GO:0019538,GO:0043170,GO:0044238,GO:0071704,GO:0140096,GO:1901564 - - - - - - - - - - PD40,Peptidase_S9 k59_1764242_1 519989.ECTPHS_09248 2.94e-30 116.0 COG1792@1|root,COG1792@2|Bacteria,1N8ZS@1224|Proteobacteria,1RMK4@1236|Gammaproteobacteria,1WWKS@135613|Chromatiales 135613|Chromatiales M Involved in formation and maintenance of cell shape - - - ko:K03570 - - - - ko00000,ko03036 9.B.157.1 - - MreC k59_1764242_2 754476.Q7A_2836 1.64e-23 97.4 COG1077@1|root,COG1077@2|Bacteria,1MUMW@1224|Proteobacteria,1RN82@1236|Gammaproteobacteria,4602K@72273|Thiotrichales 72273|Thiotrichales D TIGRFAM Cell shape determining protein MreB Mrl - - - ko:K03569 - - - - ko00000,ko02048,ko03036,ko04812 1.A.33.1,9.B.157.1 - - MreB_Mbl k59_13228_1 1392488.JHZY01000002_gene1430 4.92e-54 174.0 COG1246@1|root,COG1246@2|Bacteria,4NGXY@976|Bacteroidetes,1HZSQ@117743|Flavobacteriia,2XIF8@283735|Leeuwenhoekiella 976|Bacteroidetes E Acetyltransferase (GNAT) family - - - - - - - - - - - - Acetyltransf_1 k59_13228_2 641526.ADIWIN_0225 4.7e-111 333.0 COG1012@1|root,COG1012@2|Bacteria,4NEQ2@976|Bacteroidetes,1HYQ7@117743|Flavobacteriia 976|Bacteroidetes C Aldehyde dehydrogenase gapN - 1.2.1.9 ko:K00131 ko00010,ko00030,ko01100,ko01120,ko01200,map00010,map00030,map01100,map01120,map01200 M00308,M00633 R01058 RC00242 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_1538621_1 448385.sce6818 4.67e-92 292.0 COG2838@1|root,COG2838@2|Bacteria,1MV6Q@1224|Proteobacteria,42MY0@68525|delta/epsilon subdivisions,2WM7X@28221|Deltaproteobacteria,2YUEI@29|Myxococcales 28221|Deltaproteobacteria C Isocitrate dehydrogenase icd - 1.1.1.42 ko:K00031 ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146 M00009,M00010,M00173,M00740 R00267,R00268,R01899 RC00001,RC00084,RC00114,RC00626,RC02801 br01601,ko00000,ko00001,ko00002,ko01000 - - - IDH k59_70226_1 1366046.HIMB11_02718 3.8e-14 69.7 COG0440@1|root,COG0440@2|Bacteria,1RAGN@1224|Proteobacteria,2U5CW@28211|Alphaproteobacteria,3ZH39@58840|unclassified Rhodobacteraceae 28211|Alphaproteobacteria H acetolactate synthase, small ilvH - 2.2.1.6 ko:K01653 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - ACT,ACT_5,ALS_ss_C k59_70226_2 1122137.AQXF01000003_gene2460 8.36e-85 266.0 COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,2TR1I@28211|Alphaproteobacteria 28211|Alphaproteobacteria EH COG0028 Thiamine pyrophosphate-requiring enzymes acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase ilvI - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_238580_1 1122137.AQXF01000001_gene3161 1.74e-183 552.0 COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,1MU7B@1224|Proteobacteria,2TRHQ@28211|Alphaproteobacteria 28211|Alphaproteobacteria E glutamate synthase gltB - 1.4.1.13,1.4.1.14,1.4.7.1 ko:K00265,ko:K00284 ko00250,ko00630,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00630,map00910,map01100,map01110,map01120,map01130,map01230 - R00021,R00093,R00114,R00248,R10086 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - GATase_2,GXGXG,Glu_syn_central,Glu_synthase k59_1086064_1 316407.85676195 3.77e-138 416.0 COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,1RNBG@1236|Gammaproteobacteria,3XNHM@561|Escherichia 1236|Gammaproteobacteria L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity polA GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008408,GO:0008409,GO:0009058,GO:0009059,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901362,GO:1901363,GO:1901576 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1 k59_1424963_1 1453501.JELR01000001_gene2204 1.38e-30 112.0 COG0432@1|root,COG0432@2|Bacteria,1RH13@1224|Proteobacteria,1S3VP@1236|Gammaproteobacteria,467NM@72275|Alteromonadaceae 1236|Gammaproteobacteria S Uncharacterised protein family UPF0047 yjbQ - - - - - - - - - - - UPF0047 k59_1424963_2 1042375.AFPL01000051_gene157 2.16e-16 75.1 2CECF@1|root,32RZM@2|Bacteria,1N130@1224|Proteobacteria,1S98I@1236|Gammaproteobacteria,468FH@72275|Alteromonadaceae 1236|Gammaproteobacteria S pilin assembly protein - - - - - - - - - - - - - k59_464728_1 1341646.CBMO010000034_gene5298 1.02e-96 300.0 COG0443@1|root,COG0443@2|Bacteria,2GJTY@201174|Actinobacteria,2339Q@1762|Mycobacteriaceae 201174|Actinobacteria O Heat shock 70 kDa protein dnaK GO:0000302,GO:0000303,GO:0000305,GO:0001968,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009266,GO:0009408,GO:0009628,GO:0009893,GO:0009987,GO:0010035,GO:0010038,GO:0010468,GO:0010604,GO:0010628,GO:0010755,GO:0010756,GO:0010954,GO:0016020,GO:0016310,GO:0019222,GO:0019538,GO:0019899,GO:0030112,GO:0030162,GO:0030312,GO:0030313,GO:0031323,GO:0031325,GO:0031975,GO:0031982,GO:0032268,GO:0032270,GO:0033554,GO:0034599,GO:0034614,GO:0035375,GO:0036211,GO:0040007,GO:0042221,GO:0042603,GO:0043170,GO:0043226,GO:0043227,GO:0043230,GO:0043388,GO:0043412,GO:0044044,GO:0044093,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044403,GO:0044419,GO:0044421,GO:0044424,GO:0044444,GO:0044464,GO:0045862,GO:0046677,GO:0046688,GO:0046777,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051098,GO:0051099,GO:0051101,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0051701,GO:0051704,GO:0051716,GO:0060255,GO:0065007,GO:0065009,GO:0070613,GO:0070887,GO:0071450,GO:0071451,GO:0071704,GO:0071944,GO:0080090,GO:0097691,GO:1901564,GO:1901700,GO:1901701,GO:1903317,GO:1903319,GO:1903561,GO:2000677,GO:2000679 - ko:K04043 ko03018,ko04212,ko05152,map03018,map04212,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 1.A.33.1 - - HSP70 k59_1764256_1 765420.OSCT_2074 6.58e-27 111.0 COG0476@1|root,COG0607@1|root,COG0476@2|Bacteria,COG0607@2|Bacteria,2G5TN@200795|Chloroflexi,376KE@32061|Chloroflexia 32061|Chloroflexia HP PFAM UBA THIF-type NAD FAD binding protein - - 2.7.7.80,2.8.1.11 ko:K21029,ko:K21147 ko04122,map04122 - R07459,R07461 RC00043 ko00000,ko00001,ko01000 - - - Rhodanese,ThiF k59_296033_1 377629.TERTU_2948 1.14e-93 297.0 COG1251@1|root,COG1251@2|Bacteria,1MW58@1224|Proteobacteria,1RNGY@1236|Gammaproteobacteria,2PN5X@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria C Nitrite and sulphite reductase 4Fe-4S domain nirB - 1.7.1.15 ko:K00362 ko00910,ko01120,map00910,map01120 M00530 R00787 RC00176 ko00000,ko00001,ko00002,ko01000 - - - Fer2_BFD,NIR_SIR,NIR_SIR_ferr,Pyr_redox_2 k59_296033_2 717774.Marme_3859 6.82e-34 120.0 COG2146@1|root,COG2146@2|Bacteria,1MZBY@1224|Proteobacteria,1S9F1@1236|Gammaproteobacteria,1XKM1@135619|Oceanospirillales 135619|Oceanospirillales P Nitrite reductase nirD - 1.7.1.15 ko:K00363 ko00910,ko01120,map00910,map01120 M00530 R00787 RC00176 ko00000,ko00001,ko00002,ko01000 - - - Rieske_2 k59_296033_3 2340.JV46_10470 5.1e-25 103.0 COG0243@1|root,COG0243@2|Bacteria,1NS3T@1224|Proteobacteria,1RMWN@1236|Gammaproteobacteria,1J4DT@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family narB - - ko:K00372 ko00910,ko01120,map00910,map01120 M00531 R00798,R01106 RC02812 ko00000,ko00001,ko00002,ko01000 - - - Fer2_BFD,Molybdop_Fe4S4,Molybdopterin,Molydop_binding k59_70266_1 1380600.AUYN01000007_gene3136 3.5e-33 119.0 29E7I@1|root,3015I@2|Bacteria,4NNFG@976|Bacteroidetes,1I2ET@117743|Flavobacteriia 976|Bacteroidetes S Protein of unknown function (DUF1761) - - - - - - - - - - - - DUF1761 k59_70266_2 983544.Lacal_0992 3.25e-10 60.8 COG0008@1|root,COG0008@2|Bacteria,4NFCC@976|Bacteroidetes,1HXAH@117743|Flavobacteriia 976|Bacteroidetes J Catalyzes a two-step reaction, first charging a glutamine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA glnS - 6.1.1.18 ko:K01886 ko00970,ko01100,map00970,map01100 M00359,M00360 R03652 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_1c,tRNA-synt_1c_C k59_238607_1 436308.Nmar_0018 9.84e-27 100.0 arCOG08804@1|root,arCOG08804@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_238607_2 1229909.NSED_09745 3.33e-174 498.0 COG3263@1|root,arCOG01962@2157|Archaea,41SV3@651137|Thaumarchaeota 651137|Thaumarchaeota P Sodium hydrogen exchanger - - - ko:K11105 - - - - ko00000,ko02000 2.A.36.6 - - Na_H_Exchanger k59_1425020_1 279238.Saro_0413 9.37e-26 105.0 COG0312@1|root,COG0312@2|Bacteria,1MUSK@1224|Proteobacteria,2TRSR@28211|Alphaproteobacteria,2JZY8@204457|Sphingomonadales 204457|Sphingomonadales S peptidase U62, modulator of DNA gyrase tldD - - ko:K03568 - - - - ko00000,ko01002 - - - PmbA_TldD k59_1425020_2 702113.PP1Y_AT2277 1.51e-35 121.0 COG4391@1|root,COG4391@2|Bacteria,1PKJ0@1224|Proteobacteria,2UZ8E@28211|Alphaproteobacteria,2K88X@204457|Sphingomonadales 204457|Sphingomonadales S Zinc-finger domain - - - - - - - - - - - - zf-CHCC k59_1538678_1 570967.JMLV01000011_gene3318 9.7e-116 338.0 COG1116@1|root,COG1116@2|Bacteria,1MUIM@1224|Proteobacteria,2TRHM@28211|Alphaproteobacteria,2JQ04@204441|Rhodospirillales 204441|Rhodospirillales P ABC transporter - - - - - - - - - - - - ABC_tran k59_238613_1 702113.PP1Y_AT11604 5.14e-83 252.0 COG3246@1|root,COG3246@2|Bacteria,1MZTP@1224|Proteobacteria,2TQKN@28211|Alphaproteobacteria,2K4GI@204457|Sphingomonadales 204457|Sphingomonadales S beta-keto acid cleavage enzyme - - - - - - - - - - - - BKACE k59_1594756_1 886377.Murru_2948 1.2e-62 207.0 COG0415@1|root,COG0415@2|Bacteria,4NEDW@976|Bacteroidetes,1HXRR@117743|Flavobacteriia 976|Bacteroidetes L Belongs to the DNA photolyase family phr - 4.1.99.3 ko:K01669 - - - - ko00000,ko01000,ko03400 - - - DNA_photolyase,FAD_binding_7 k59_352510_1 187272.Mlg_2589 9.18e-66 216.0 COG0715@1|root,COG0715@2|Bacteria,1MWDN@1224|Proteobacteria,1RPUP@1236|Gammaproteobacteria,1X02P@135613|Chromatiales 135613|Chromatiales P NMT1-like family - - - ko:K15576 ko00910,ko02010,map00910,map02010 M00438 - - ko00000,ko00001,ko00002,ko02000 3.A.1.16.1,3.A.1.16.2 - - NMT1_2 k59_861381_2 1435356.Y013_15815 1.76e-20 91.3 COG2066@1|root,COG2066@2|Bacteria,2GKAV@201174|Actinobacteria,4FVII@85025|Nocardiaceae 201174|Actinobacteria E Belongs to the glutaminase family glsA - 3.5.1.2 ko:K01425 ko00220,ko00250,ko00471,ko01100,ko04724,ko04727,ko04964,ko05206,ko05230,map00220,map00250,map00471,map01100,map04724,map04727,map04964,map05206,map05230 - R00256,R01579 RC00010,RC02798 ko00000,ko00001,ko01000 - - - Glutaminase,STAS k59_690777_1 551275.KB899549_gene857 7.19e-14 76.3 COG1629@1|root,COG4771@2|Bacteria,1MWKN@1224|Proteobacteria,2TT5V@28211|Alphaproteobacteria 28211|Alphaproteobacteria P TonB-dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_520791_1 583355.Caka_0943 4.47e-77 246.0 COG5016@1|root,COG5016@2|Bacteria,46TT6@74201|Verrucomicrobia,3K76D@414999|Opitutae 414999|Opitutae C Pyruvate carboxyltransferase - - 4.1.1.3,6.4.1.1 ko:K01571,ko:K01960 ko00020,ko00620,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00720,map01100,map01120,map01200,map01230 M00173,M00620 R00217,R00344 RC00040,RC00367 ko00000,ko00001,ko00002,ko01000,ko02000 3.B.1.1.1 - - HMGL-like,PYC_OADA k59_1312882_1 62928.azo0148 5.97e-72 237.0 COG0204@1|root,COG0204@2|Bacteria,1MWDY@1224|Proteobacteria,2VJ4I@28216|Betaproteobacteria,2KV3W@206389|Rhodocyclales 206389|Rhodocyclales I Transmembrane secretion effector - - - - - - - - - - - - Acyltransferase,MFS_1 k59_182547_2 1410658.JHWI01000023_gene1176 1.06e-21 100.0 COG1479@1|root,COG1637@1|root,COG1479@2|Bacteria,COG1637@2|Bacteria,1TPAT@1239|Firmicutes,3VS4G@526524|Erysipelotrichia 526524|Erysipelotrichia L Protein of unknown function (DUF1524) - - - - - - - - - - - - DUF1524,DUF262,DUF4268 k59_861390_1 1415779.JOMH01000001_gene1735 9.96e-88 269.0 COG0715@1|root,COG0715@2|Bacteria,1MVJA@1224|Proteobacteria,1RUI0@1236|Gammaproteobacteria 1236|Gammaproteobacteria P COG0715 ABC-type nitrate sulfonate bicarbonate transport systems, periplasmic components - - - ko:K02051 - M00188 - - ko00000,ko00002,ko02000 3.A.1.16,3.A.1.17 - - NMT1,NMT1_2 k59_1651588_2 585.DR95_3610 5.57e-19 89.4 COG2918@1|root,COG2918@2|Bacteria,1MW9B@1224|Proteobacteria,1RPNQ@1236|Gammaproteobacteria,3Z1M0@583|Proteus 1236|Gammaproteobacteria H Glutamate-cysteine ligase gshA GO:0003674,GO:0003824,GO:0004357,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006518,GO:0006575,GO:0006749,GO:0006750,GO:0006790,GO:0006807,GO:0006950,GO:0006970,GO:0006972,GO:0008150,GO:0008152,GO:0009058,GO:0009628,GO:0009987,GO:0010035,GO:0010038,GO:0016874,GO:0016879,GO:0016881,GO:0019184,GO:0034641,GO:0042221,GO:0042398,GO:0043043,GO:0043167,GO:0043169,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044424,GO:0044444,GO:0044464,GO:0046685,GO:0046689,GO:0046872,GO:0050896,GO:0051186,GO:0051188,GO:0051716,GO:0070887,GO:0071241,GO:0071243,GO:0071248,GO:0071288,GO:0071704,GO:1901564,GO:1901566,GO:1901576 6.3.2.2 ko:K01919 ko00270,ko00480,ko01100,map00270,map00480,map01100 M00118 R00894,R10993 RC00064,RC00090 ko00000,ko00001,ko00002,ko01000 - - iEC042_1314.EC042_2885 Glu_cys_ligase k59_182552_1 292415.Tbd_2112 3.41e-105 320.0 COG0442@1|root,COG0442@2|Bacteria,1MU7E@1224|Proteobacteria,2VGZ9@28216|Betaproteobacteria,1KS96@119069|Hydrogenophilales 119069|Hydrogenophilales J Aminoacyl-tRNA editing domain - - 6.1.1.15 ko:K01881 ko00970,map00970 M00359,M00360 R03661 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,tRNA-synt_2b,tRNA_edit k59_747039_1 5786.XP_003288550.1 6.96e-11 67.8 COG0326@1|root,KOG0020@2759|Eukaryota,3XCIV@554915|Amoebozoa 554915|Amoebozoa O Hsp90 protein - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005783,GO:0005794,GO:0005798,GO:0012505,GO:0031410,GO:0031982,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464,GO:0097708 - ko:K09487 ko04141,ko04151,ko04626,ko04657,ko04915,ko04918,ko05200,ko05215,ko05418,map04141,map04151,map04626,map04657,map04915,map04918,map05200,map05215,map05418 - - - ko00000,ko00001,ko03110 - - - HATPase_c,HSP90 k59_126309_1 794903.OPIT5_17150 1.57e-81 251.0 COG0560@1|root,COG0560@2|Bacteria,46UCT@74201|Verrucomicrobia,3K7I3@414999|Opitutae 414999|Opitutae E Phosphoserine phosphatase - - - - - - - - - - - - - k59_634339_1 8083.ENSXMAP00000010599 7.56e-69 224.0 COG3844@1|root,KOG3846@2759|Eukaryota,38BHE@33154|Opisthokonta,3BACM@33208|Metazoa,3CXIZ@33213|Bilateria,4863I@7711|Chordata,4963G@7742|Vertebrata,4A066@7898|Actinopterygii 33208|Metazoa E Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively KYNU GO:0002376,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005829,GO:0006082,GO:0006084,GO:0006139,GO:0006163,GO:0006520,GO:0006568,GO:0006569,GO:0006576,GO:0006586,GO:0006637,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006766,GO:0006767,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006952,GO:0006955,GO:0007584,GO:0008144,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009063,GO:0009072,GO:0009074,GO:0009108,GO:0009117,GO:0009150,GO:0009165,GO:0009259,GO:0009308,GO:0009310,GO:0009435,GO:0009605,GO:0009987,GO:0009991,GO:0010033,GO:0010243,GO:0014070,GO:0016053,GO:0016054,GO:0016787,GO:0016822,GO:0016823,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019441,GO:0019442,GO:0019637,GO:0019674,GO:0019693,GO:0019752,GO:0019805,GO:0019842,GO:0030170,GO:0030429,GO:0031667,GO:0031974,GO:0031981,GO:0032787,GO:0033273,GO:0033865,GO:0033875,GO:0034032,GO:0034097,GO:0034341,GO:0034516,GO:0034641,GO:0034654,GO:0035383,GO:0036094,GO:0042180,GO:0042221,GO:0042402,GO:0042430,GO:0042436,GO:0042493,GO:0042537,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043420,GO:0043436,GO:0043603,GO:0043648,GO:0043650,GO:0044106,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0044422,GO:0044424,GO:0044428,GO:0044444,GO:0044446,GO:0044464,GO:0045087,GO:0046218,GO:0046394,GO:0046395,GO:0046483,GO:0046496,GO:0046700,GO:0046874,GO:0046983,GO:0048037,GO:0050662,GO:0050896,GO:0051186,GO:0051188,GO:0055086,GO:0061981,GO:0070013,GO:0070189,GO:0070279,GO:0071704,GO:0072521,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:1901135,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1901698 3.7.1.3 ko:K01556 ko00380,ko01100,map00380,map01100 M00038 R00987,R02668,R03936 RC00284,RC00415 ko00000,ko00001,ko00002,ko01000 - - - Aminotran_5 k59_1086165_1 158500.BV97_05277 2e-80 243.0 COG3797@1|root,COG3797@2|Bacteria,1N0SN@1224|Proteobacteria,2U9NX@28211|Alphaproteobacteria,2K5A2@204457|Sphingomonadales 204457|Sphingomonadales S Protein of unknown function (DUF1697) - - - - - - - - - - - - DUF1697 k59_972559_1 194439.CT2081 6.41e-74 237.0 COG0446@1|root,COG0446@2|Bacteria,1FDM3@1090|Chlorobi 1090|Chlorobi C PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase - - 1.8.2.3 ko:K17229 ko00920,ko01120,map00920,map01120 - R09499 - ko00000,ko00001,ko01000 - - - FCSD-flav_bind,Pyr_redox_2 k59_690807_1 511145.b1815 7.19e-121 358.0 COG2200@1|root,COG2200@2|Bacteria,1QUCV@1224|Proteobacteria,1T1TN@1236|Gammaproteobacteria,3XNZ2@561|Escherichia 1236|Gammaproteobacteria T overexpression inhibits cell aggregation in strains able to produce adhesive curli fimbriae. Cyclic-di-GMP is a second messenger which controls cell surface-associated traits in bacteria yoaD GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0033554,GO:0050896,GO:0051716 3.1.4.52 ko:K21090 ko02026,map02026 - - - ko00000,ko00001,ko01000 - - - CSS-motif,EAL k59_1425076_1 344747.PM8797T_15536 1.22e-23 100.0 COG0569@1|root,COG0569@2|Bacteria 2|Bacteria P domain protein - - - - - - - - - - - - TrkA_C k59_1594795_2 717774.Marme_1005 2.8e-37 140.0 COG1360@1|root,COG1360@2|Bacteria,1QUFR@1224|Proteobacteria,1T1XE@1236|Gammaproteobacteria,1XHZ9@135619|Oceanospirillales 135619|Oceanospirillales N Flagellar motor protein motB - - ko:K02557 ko02030,ko02040,map02030,map02040 - - - ko00000,ko00001,ko02000,ko02035 1.A.30.1 - - MotB_plug,OmpA k59_13356_1 583355.Caka_1793 8.21e-60 196.0 COG0618@1|root,COG0618@2|Bacteria,46T03@74201|Verrucomicrobia,3K7K6@414999|Opitutae 414999|Opitutae S DHH family - - 3.1.13.3,3.1.3.7 ko:K06881 ko00920,ko01100,ko01120,map00920,map01100,map01120 - R00188,R00508 RC00078 ko00000,ko00001,ko01000,ko03400 - - - DHH,DHHA1 k59_690825_1 436308.Nmar_1718 7.06e-121 352.0 COG1829@1|root,arCOG04263@2157|Archaea,41T1V@651137|Thaumarchaeota 651137|Thaumarchaeota S kinase, sugar kinase superfamily - - 2.7.1.169 ko:K06982 ko00770,ko01100,map00770,map01100 - R09378 RC00002,RC00017 ko00000,ko00001,ko01000 - - - GHMP_kinases_N k59_1538770_1 1313172.YM304_07480 1.19e-124 372.0 COG1053@1|root,COG1053@2|Bacteria,2GJ45@201174|Actinobacteria,4CN0E@84992|Acidimicrobiia 84992|Acidimicrobiia C Fumarate reductase flavoprotein C-term sdhA - 1.3.5.1,1.3.5.4 ko:K00239 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134 M00009,M00011,M00149,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,Succ_DH_flav_C k59_1369530_1 1163617.SCD_n00732 1.36e-66 219.0 COG1807@1|root,COG1807@2|Bacteria,1PUE3@1224|Proteobacteria,2VHPU@28216|Betaproteobacteria 28216|Betaproteobacteria M 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family - - - - - - - - - - - - PMT_2 k59_1594804_1 1122137.AQXF01000007_gene3502 2.73e-30 116.0 COG1748@1|root,COG1748@2|Bacteria,1MY1G@1224|Proteobacteria,2U0RS@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Saccharopine dehydrogenase lys2 - 1.4.1.18,1.5.1.10 ko:K00293,ko:K19064 ko00300,ko00310,ko00960,ko01100,ko01110,ko01130,ko01230,map00300,map00310,map00960,map01100,map01110,map01130,map01230 M00030,M00032 R00446,R02315,R02317 RC00062,RC00215,RC00225,RC00694 ko00000,ko00001,ko00002,ko01000 - - - Sacchrp_dh_C,Sacchrp_dh_NADP k59_1594804_2 1122137.AQXF01000007_gene3503 1.2e-110 334.0 COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,2TSB1@28211|Alphaproteobacteria 28211|Alphaproteobacteria EH Belongs to the TPP enzyme family - - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_1594805_1 1238186.AOCN01000022_gene2326 4.97e-25 104.0 COG3971@1|root,COG3971@2|Bacteria,2GPBI@201174|Actinobacteria,4FK5C@85023|Microbacteriaceae 201174|Actinobacteria Q Fumarylacetoacetate (FAA) hydrolase family hpaH - - ko:K02509 ko00350,ko01120,map00350,map01120 - R04132,R06897 RC01615,RC02595 ko00000,ko00001,ko01000 - - - FAA_hydrolase k59_1594827_1 436308.Nmar_1408 3.15e-45 160.0 COG1389@1|root,arCOG01165@2157|Archaea,41SJ2@651137|Thaumarchaeota 651137|Thaumarchaeota L Relaxes both positive and negative superturns and exhibits a strong decatenase activity top6B - 5.99.1.3 ko:K03167 - - - - ko00000,ko01000,ko03032 - - - HATPase_c,Topo-VIb_trans k59_1594827_2 1229909.NSED_07730 4.88e-29 113.0 COG1697@1|root,arCOG04143@2157|Archaea,41SQF@651137|Thaumarchaeota 651137|Thaumarchaeota L Relaxes both positive and negative superturns and exhibits a strong decatenase activity top6A - 5.99.1.3 ko:K03166 - - - - ko00000,ko01000,ko03032 - - - TP6A_N k59_182602_1 349521.HCH_05426 2.49e-88 276.0 COG4773@1|root,COG4773@2|Bacteria,1QWRF@1224|Proteobacteria,1RN9A@1236|Gammaproteobacteria,1XHTP@135619|Oceanospirillales 135619|Oceanospirillales P Receptor - - - - - - - - - - - - - k59_804461_1 391037.Sare_4794 1.05e-20 96.7 COG0003@1|root,COG0003@2|Bacteria,2GJYN@201174|Actinobacteria,4D8U6@85008|Micromonosporales 201174|Actinobacteria P Anion-transporting ATPase - - - - - - - - - - - - ArsA_ATPase k59_804461_2 1120963.KB894491_gene649 6.78e-39 147.0 COG1033@1|root,COG1033@2|Bacteria,1MUE1@1224|Proteobacteria,1RN01@1236|Gammaproteobacteria,2Q0RI@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria S of the RND superfamily - - - ko:K07003 - - - - ko00000 - - - MMPL k59_634384_1 207954.MED92_13523 3.65e-79 246.0 COG2010@1|root,COG3245@1|root,COG2010@2|Bacteria,COG3245@2|Bacteria,1QVK1@1224|Proteobacteria,1RYEK@1236|Gammaproteobacteria,1XI9N@135619|Oceanospirillales 135619|Oceanospirillales C Cytochrome C oxidase, cbb3-type, subunit III - - - - - - - - - - - - Cytochrome_CBB3 k59_70374_1 1313172.YM304_15060 6.3e-51 176.0 COG0006@1|root,COG0006@2|Bacteria,2GM7D@201174|Actinobacteria,4CMRJ@84992|Acidimicrobiia 84992|Acidimicrobiia E Creatinase/Prolidase N-terminal domain - - - - - - - - - - - - Creatinase_N,Peptidase_M24 k59_747099_1 1229909.NSED_02195 4.42e-75 237.0 COG0065@1|root,arCOG01698@2157|Archaea,41SYT@651137|Thaumarchaeota 651137|Thaumarchaeota E 3-isopropylmalate dehydratase, large subunit - - 4.2.1.33,4.2.1.35 ko:K01703 ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230 M00432,M00535 R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170 RC00497,RC00976,RC00977,RC01041,RC01046,RC03072 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase k59_747099_2 436308.Nmar_0421 6.46e-35 122.0 COG0066@1|root,arCOG02230@2157|Archaea,41SIA@651137|Thaumarchaeota 651137|Thaumarchaeota E 3-isopropylmalate dehydratase, small subunit - - 4.2.1.33,4.2.1.35 ko:K01704 ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230 M00432,M00535 R03896,R03898,R03968,R04001,R10170 RC00976,RC00977,RC01041,RC01046,RC03072 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase_C k59_182610_1 1177154.Y5S_03592 2.48e-11 63.2 COG3764@1|root,COG3764@2|Bacteria,1P806@1224|Proteobacteria,1S9RI@1236|Gammaproteobacteria,1XMGQ@135619|Oceanospirillales 135619|Oceanospirillales M Sortase (surface protein transpeptidase) - - 3.4.22.70 ko:K07284 - - - - ko00000,ko01000,ko01002,ko01011 - - - Sortase k59_182610_2 866536.Belba_2416 8.58e-52 168.0 COG0494@1|root,COG0494@2|Bacteria,4NMHV@976|Bacteroidetes,47P7M@768503|Cytophagia 976|Bacteroidetes L pfam nudix nudF - - - - - - - - - - - NUDIX k59_747102_1 1122137.AQXF01000004_gene1837 3.29e-20 87.0 COG0500@1|root,COG2226@2|Bacteria,1PA5F@1224|Proteobacteria,2TRFS@28211|Alphaproteobacteria 28211|Alphaproteobacteria Q COG0500 SAM-dependent methyltransferases bioC - - - - - - - - - - - Methyltransf_11,Methyltransf_23 k59_747102_2 1122137.AQXF01000004_gene1836 1.52e-50 166.0 COG3575@1|root,COG3575@2|Bacteria,1RK7B@1224|Proteobacteria 1224|Proteobacteria S Nucleotidyltransferase - - - ko:K09962 - - - - ko00000 - - - NTP_transf_6 k59_972605_1 748247.AZKH_4100 7.05e-105 315.0 COG0644@1|root,COG0644@2|Bacteria,1MVU6@1224|Proteobacteria,2VH37@28216|Betaproteobacteria,2KU8X@206389|Rhodocyclales 28216|Betaproteobacteria C FAD dependent oxidoreductase fixC - - ko:K00313 - - - - ko00000,ko01000 - - - DAO,FAD_binding_3,FAD_oxidored,GIDA k59_13397_2 1535422.ND16A_1645 9.84e-48 157.0 COG0848@1|root,COG0848@2|Bacteria,1RI4M@1224|Proteobacteria,1S4GX@1236|Gammaproteobacteria,2Q83H@267889|Colwelliaceae 1236|Gammaproteobacteria U Biopolymer transport protein ExbD/TolR - - - ko:K03559 - - - - ko00000,ko02000 1.A.30.2.1 - - ExbD k59_13397_3 740709.A10D4_00920 3.55e-36 129.0 COG0811@1|root,COG0811@2|Bacteria,1MX60@1224|Proteobacteria,1RRX1@1236|Gammaproteobacteria,2QFR5@267893|Idiomarinaceae 1236|Gammaproteobacteria U Biopolymer - - - ko:K03561 - - - - ko00000,ko02000 1.A.30.2.1 - - MotA_ExbB k59_182612_1 702113.PP1Y_AT29868 1.95e-106 334.0 COG0550@1|root,COG1754@1|root,COG0550@2|Bacteria,COG1754@2|Bacteria,1MUFZ@1224|Proteobacteria,2TRGN@28211|Alphaproteobacteria,2K2HN@204457|Sphingomonadales 204457|Sphingomonadales L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone topA - 5.99.1.2 ko:K03168 - - - - ko00000,ko01000,ko03032,ko03400 - - - Topoisom_bac,Toprim,Toprim_C_rpt,zf-C4_Topoisom k59_135671_1 314287.GB2207_06518 3.04e-74 231.0 COG0614@1|root,COG0614@2|Bacteria,1MWVF@1224|Proteobacteria,1RMV8@1236|Gammaproteobacteria,1J651@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P COG0614 ABC-type Fe3 -hydroxamate transport system, periplasmic component btuF GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0006810,GO:0008144,GO:0008150,GO:0015889,GO:0015893,GO:0019842,GO:0030288,GO:0030313,GO:0031419,GO:0031975,GO:0036094,GO:0042221,GO:0042493,GO:0042597,GO:0044464,GO:0046906,GO:0048037,GO:0050896,GO:0051179,GO:0051180,GO:0051181,GO:0051234,GO:0071702,GO:0071705,GO:0097159,GO:1901363 - ko:K02016,ko:K06858 ko02010,map02010 M00240,M00241 - - ko00000,ko00001,ko00002,ko02000 3.A.1.13,3.A.1.14 - iECH74115_1262.ECH74115_0168,iECSP_1301.ECSP_0159,iECs_1301.ECs0162,iZ_1308.Z0169 Peripla_BP_2 k59_1208885_1 118005.AWNK01000005_gene1540 9.35e-29 114.0 COG0785@1|root,COG0785@2|Bacteria 2|Bacteria O Cytochrome C biogenesis protein ccdA - 1.8.4.11,1.8.4.12 ko:K06196,ko:K12267 - - - - ko00000,ko01000,ko02000 5.A.1.2 - - AhpC-TSA,DsbD k59_1379000_1 99598.Cal7507_1942 1.69e-07 49.3 COG2929@1|root,COG2929@2|Bacteria,1G8FA@1117|Cyanobacteria 1117|Cyanobacteria S Ribonuclease toxin, BrnT, of type II toxin-antitoxin system - - - ko:K09803 - - - - ko00000 - - - BrnT_toxin k59_1379000_2 195253.Syn6312_1026 1.59e-31 113.0 COG3514@1|root,COG3514@2|Bacteria,1G7ND@1117|Cyanobacteria 1117|Cyanobacteria S SPTR CopG domain protein DNA-binding domain protein - - - - - - - - - - - - BrnA_antitoxin k59_305745_1 743836.AYNA01000044_gene1106 1.08e-38 143.0 COG1413@1|root,COG1413@2|Bacteria,1N94K@1224|Proteobacteria,2U34H@28211|Alphaproteobacteria,36ZS8@31993|Methylocystaceae 28211|Alphaproteobacteria C LRV protein FeS4 cluster - - - - - - - - - - - - LRV,LRV_FeS k59_135691_2 1380391.JIAS01000014_gene1994 3.64e-10 61.6 COG4452@1|root,COG4452@2|Bacteria,1MVVR@1224|Proteobacteria,2TVJ2@28211|Alphaproteobacteria,2JWNQ@204441|Rhodospirillales 204441|Rhodospirillales V Inner membrane protein CreD - - - - - - - - - - - - CreD k59_135691_3 1122604.JONR01000010_gene3984 3.99e-15 79.0 COG4452@1|root,COG4452@2|Bacteria,1MVVR@1224|Proteobacteria,1RQRZ@1236|Gammaproteobacteria,1X4YB@135614|Xanthomonadales 135614|Xanthomonadales V Inner membrane protein involved in colicin E2 resistance creD - - ko:K06143 - - - - ko00000 - - - CreD k59_755906_1 436308.Nmar_0285 2.41e-265 741.0 COG1009@1|root,arCOG01539@2157|Archaea,41SC4@651137|Thaumarchaeota 651137|Thaumarchaeota C TIGRFAM proton-translocating NADH-quinone oxidoreductase, chain L - - 1.6.5.3 ko:K00341 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Proton_antipo_M,Proton_antipo_N k59_1548420_1 452662.SJA_C2-02910 5.78e-30 120.0 COG1716@1|root,COG1716@2|Bacteria,1R72N@1224|Proteobacteria,2U42V@28211|Alphaproteobacteria,2K0ZA@204457|Sphingomonadales 204457|Sphingomonadales C Cytochrome c3 - - - - - - - - - - - - Cytochrom_c3_2 k59_1152075_2 105420.BBPO01000057_gene3487 7.3e-26 98.6 2DEAM@1|root,32U30@2|Bacteria,2IQPT@201174|Actinobacteria,2NJF2@228398|Streptacidiphilus 201174|Actinobacteria - - - - - - - - - - - - - - - k59_1152075_3 1206733.BAGC01000071_gene4424 1.06e-12 66.6 COG0449@1|root,COG0449@2|Bacteria,2GKH0@201174|Actinobacteria,4FV0N@85025|Nocardiaceae 201174|Actinobacteria M SIS domain glmS - 2.6.1.16 ko:K00820 ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931 - R00768 RC00010,RC00163,RC02752 ko00000,ko00001,ko01000,ko01002 - - - GATase_6,SIS k59_191698_1 1323663.AROI01000009_gene3481 7.14e-17 85.1 COG4447@1|root,COG4447@2|Bacteria,1RCNG@1224|Proteobacteria,1S1N2@1236|Gammaproteobacteria 1236|Gammaproteobacteria S protein related to plant photosystem II stability assembly factor - - - - - - - - - - - - PSII_BNR k59_870917_1 1545915.JROG01000001_gene554 3.48e-66 208.0 COG1028@1|root,COG1028@2|Bacteria,1MWB6@1224|Proteobacteria,2TUKJ@28211|Alphaproteobacteria,2K0AT@204457|Sphingomonadales 204457|Sphingomonadales IQ Enoyl-(Acyl carrier protein) reductase - - 1.1.1.127 ko:K00065 ko00040,map00040 - R01542 RC00089 ko00000,ko00001,ko01000 - - - adh_short_C2 k59_812881_1 1137281.D778_00990 3.93e-83 268.0 COG0022@1|root,COG1071@1|root,COG0022@2|Bacteria,COG1071@2|Bacteria,4NE4A@976|Bacteroidetes,1HYUM@117743|Flavobacteriia 976|Bacteroidetes C Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type pdhB - 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 - - - E1_dh,Transket_pyr,Transketolase_C k59_587275_1 1479237.JMLY01000001_gene2046 2.14e-82 263.0 COG0556@1|root,COG0556@2|Bacteria,1MUFK@1224|Proteobacteria,1RN6Z@1236|Gammaproteobacteria,4645B@72275|Alteromonadaceae 1236|Gammaproteobacteria L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage uvrB GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009314,GO:0009380,GO:0009628,GO:0032991,GO:0042802,GO:0044424,GO:0044464,GO:0050896,GO:1902494,GO:1905347,GO:1905348,GO:1990391 - ko:K03702 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - Helicase_C,ResIII,UVR,UvrB k59_1379020_1 1523503.JPMY01000010_gene2582 1.04e-14 79.0 COG3712@1|root,COG3712@2|Bacteria,1N28G@1224|Proteobacteria,1RR9M@1236|Gammaproteobacteria 1236|Gammaproteobacteria PT Fe2 -dicitrate sensor, membrane component - - - ko:K07165 - - - - ko00000 - - - DUF4880,DUF4974,FecR k59_135707_1 574375.BAGA_00085 5.56e-05 49.3 COG1426@1|root,COG1426@2|Bacteria,1V1N7@1239|Firmicutes,4HKW3@91061|Bacilli,1ZDC1@1386|Bacillus 91061|Bacilli S protein conserved in bacteria ymfM - - ko:K15539 - - - - ko00000 - - - DUF4115,HTH_25 k59_870921_1 702113.PP1Y_AT10368 1.79e-38 142.0 COG1414@1|root,COG1414@2|Bacteria,1QRZN@1224|Proteobacteria,2TU6N@28211|Alphaproteobacteria,2K7AP@204457|Sphingomonadales 204457|Sphingomonadales K Transcriptional regulator - - - ko:K05818 - - - - ko00000,ko03000 - - - HTH_IclR,IclR k59_643089_1 323848.Nmul_A0474 3.86e-113 343.0 COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,2VJ55@28216|Betaproteobacteria,372AD@32003|Nitrosomonadales 28216|Betaproteobacteria H TIGRFAM Acetolactate synthase, large subunit, biosynthetic ilvI - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_248140_1 1144305.PMI02_05440 2.62e-12 67.0 COG1309@1|root,COG1309@2|Bacteria,1NMPS@1224|Proteobacteria,2UK21@28211|Alphaproteobacteria,2KAHI@204457|Sphingomonadales 204457|Sphingomonadales K PFAM Bacterial regulatory proteins, tetR family - - - - - - - - - - - - TetR_N k59_248140_2 1194165.CAJF01000036_gene1691 7.17e-13 70.9 COG1028@1|root,COG1028@2|Bacteria,2IAGY@201174|Actinobacteria 201174|Actinobacteria IQ KR domain - - - - - - - - - - - - adh_short_C2 k59_1604613_2 1229909.NSED_07315 4.52e-153 434.0 COG1028@1|root,arCOG01259@2157|Archaea,41SGH@651137|Thaumarchaeota 651137|Thaumarchaeota I Belongs to the short-chain dehydrogenases reductases (SDR) family - - - - - - - - - - - - adh_short k59_755918_1 316407.1736538 1.72e-113 339.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,1RMH0@1236|Gammaproteobacteria,3XNE9@561|Escherichia 1236|Gammaproteobacteria NT Methyl-accepting chemotaxis protein tap GO:0001101,GO:0001932,GO:0003674,GO:0004888,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006928,GO:0006935,GO:0007154,GO:0007165,GO:0007172,GO:0008104,GO:0008150,GO:0009593,GO:0009605,GO:0009719,GO:0009893,GO:0009966,GO:0009987,GO:0010033,GO:0010243,GO:0010604,GO:0010646,GO:0016020,GO:0016021,GO:0016043,GO:0019220,GO:0019222,GO:0019899,GO:0019900,GO:0019901,GO:0022607,GO:0023051,GO:0023052,GO:0031224,GO:0031226,GO:0031323,GO:0031325,GO:0031399,GO:0031401,GO:0032101,GO:0032110,GO:0032268,GO:0032270,GO:0032879,GO:0032991,GO:0033036,GO:0034613,GO:0034622,GO:0038023,GO:0040011,GO:0040012,GO:0042221,GO:0042325,GO:0042330,GO:0042802,GO:0042803,GO:0043113,GO:0043200,GO:0043424,GO:0043549,GO:0043933,GO:0044085,GO:0044425,GO:0044459,GO:0044464,GO:0045859,GO:0046983,GO:0048518,GO:0048522,GO:0048583,GO:0048870,GO:0050789,GO:0050790,GO:0050794,GO:0050896,GO:0050920,GO:0051171,GO:0051173,GO:0051174,GO:0051179,GO:0051246,GO:0051247,GO:0051259,GO:0051260,GO:0051270,GO:0051338,GO:0051606,GO:0051641,GO:0051668,GO:0051674,GO:0051716,GO:0060089,GO:0060255,GO:0065003,GO:0065007,GO:0065009,GO:0070727,GO:0070887,GO:0071229,GO:0071230,GO:0071310,GO:0071417,GO:0071495,GO:0071840,GO:0071944,GO:0072657,GO:0080090,GO:0098561,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1901873,GO:1901875,GO:1902021,GO:2000145 - ko:K03406,ko:K05874,ko:K05875,ko:K05876,ko:K05877 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - HAMP,MCPsignal,TarH k59_870925_1 326297.Sama_2453 1.93e-103 329.0 COG0296@1|root,COG0296@2|Bacteria,1QTVN@1224|Proteobacteria,1RQSK@1236|Gammaproteobacteria,2Q9CX@267890|Shewanellaceae 1236|Gammaproteobacteria G Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position glgB GO:0000271,GO:0003674,GO:0003824,GO:0003844,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0006073,GO:0006091,GO:0006112,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0015980,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033554,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716,GO:0055114,GO:0071704,GO:1901576 2.4.1.18 ko:K00700 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R02110 - ko00000,ko00001,ko00002,ko01000,ko04147 - CBM48,GH13 iAPECO1_1312.APECO1_3025,iECNA114_1301.ECNA114_3542,iECOK1_1307.ECOK1_3857,iECS88_1305.ECS88_3830,iECSF_1327.ECSF_3253,iLF82_1304.LF82_0837,iNRG857_1313.NRG857_17030,iUTI89_1310.UTI89_C3941 Alpha-amylase,Alpha-amylase_C,CBM_48 k59_870925_2 314275.MADE_1011670 1.05e-38 149.0 COG1640@1|root,COG1640@2|Bacteria,1QTVJ@1224|Proteobacteria,1RMJW@1236|Gammaproteobacteria,464MS@72275|Alteromonadaceae 1236|Gammaproteobacteria G 4-alpha-glucanotransferase malQ - 2.4.1.25 ko:K00705 ko00500,ko01100,map00500,map01100 - R05196 RC00049 ko00000,ko00001,ko01000 - GH77 - Glyco_hydro_77 k59_529229_1 1120971.AUCA01000011_gene2943 1.3e-84 256.0 COG0264@1|root,COG0264@2|Bacteria,1TPFJ@1239|Firmicutes,4HBDV@91061|Bacilli,27828@186823|Alicyclobacillaceae 91061|Bacilli J Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome tsf GO:0001871,GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005623,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009986,GO:0009987,GO:0010467,GO:0019538,GO:0030246,GO:0030247,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:2001065 - ko:K02357 - - - - ko00000,ko03012,ko03029 - - - EF_TS k59_22815_1 1268635.Loa_01217 9.19e-39 140.0 COG1077@1|root,COG1077@2|Bacteria,1MUMW@1224|Proteobacteria,1RN82@1236|Gammaproteobacteria,1JCF6@118969|Legionellales 118969|Legionellales D Actin mreB - - ko:K03569 - - - - ko00000,ko02048,ko03036,ko04812 1.A.33.1,9.B.157.1 - - MreB_Mbl k59_473505_1 864051.BurJ1DRAFT_2488 4.25e-25 102.0 COG2084@1|root,COG2084@2|Bacteria,1PGX8@1224|Proteobacteria,2W9GF@28216|Betaproteobacteria,1KNSJ@119065|unclassified Burkholderiales 28216|Betaproteobacteria I NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase - - - - - - - - - - - - NAD_binding_11,NAD_binding_2 k59_473515_1 395494.Galf_2285 1.98e-13 74.3 COG3134@1|root,COG3134@2|Bacteria,1MVWD@1224|Proteobacteria,2VTZ2@28216|Betaproteobacteria 28216|Betaproteobacteria S Glycine zipper 2TM domain - - - - - - - - - - - - Rick_17kDa_Anti k59_305811_1 1288826.MSNKSG1_15926 3.41e-47 169.0 COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,1RPG7@1236|Gammaproteobacteria,466C3@72275|Alteromonadaceae 1236|Gammaproteobacteria IQ COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II - - - - - - - - - - - - AMP-binding,AMP-binding_C k59_417856_1 216596.RL2855 3.26e-08 58.2 COG0583@1|root,COG0583@2|Bacteria,1Q531@1224|Proteobacteria,2U0V4@28211|Alphaproteobacteria,4BBHD@82115|Rhizobiaceae 28211|Alphaproteobacteria K LysR family transcriptional regulator - - - - - - - - - - - - HTH_1,LysR_substrate k59_1433805_1 709797.CSIRO_4255 1.23e-22 97.4 COG1352@1|root,COG1352@2|Bacteria,1MU6W@1224|Proteobacteria,2TRQ3@28211|Alphaproteobacteria,3JTPM@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria NT Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP cheR - 2.1.1.80 ko:K00575 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko01000,ko02035 - - - CheR,CheR_N k59_1433805_2 358220.C380_09615 6.09e-10 62.8 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,2VGZ8@28216|Betaproteobacteria,4AGAQ@80864|Comamonadaceae 28216|Betaproteobacteria NT COG0840 Methyl-accepting chemotaxis protein - - - ko:K03406,ko:K03776,ko:K05875 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - 4HB_MCP_1,HAMP,MCPsignal,PAS_3 k59_1717441_1 991905.SL003B_3212 6.37e-44 157.0 COG3278@1|root,COG3278@2|Bacteria,1MU18@1224|Proteobacteria,2TR2C@28211|Alphaproteobacteria,4BR8R@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria C Cytochrome C and Quinol oxidase polypeptide I ccoN GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015672,GO:0015980,GO:0015988,GO:0015990,GO:0016020,GO:0022900,GO:0022904,GO:0034220,GO:0044237,GO:0044464,GO:0045333,GO:0051179,GO:0051234,GO:0055085,GO:0055114,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:1902600 1.9.3.1 ko:K00404 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00156 - - ko00000,ko00001,ko00002,ko01000 3.D.4.3 - - COX1 k59_1717441_2 861208.AGROH133_06267 4.1e-16 76.3 COG2993@1|root,COG2993@2|Bacteria,1MXEY@1224|Proteobacteria,2TRGW@28211|Alphaproteobacteria,4BASB@82115|Rhizobiaceae 28211|Alphaproteobacteria C cytochrome C oxidase mono-heme subunit FixO ccoO - - ko:K00405 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00156 - - ko00000,ko00001,ko00002 3.D.4.3 - - FixO k59_80201_1 1144305.PMI02_00878 1.7e-27 110.0 COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2TQR1@28211|Alphaproteobacteria,2JZVD@204457|Sphingomonadales 204457|Sphingomonadales C belongs to the aldehyde dehydrogenase family - - 1.2.1.39 ko:K00146 ko00360,ko00643,ko01100,ko01120,map00360,map00643,map01100,map01120 - R02536 RC00080 ko00000,ko00001,ko01000 - - - Aldedh k59_80201_2 1144305.PMI02_00877 7.97e-62 206.0 COG0145@1|root,COG0145@2|Bacteria,1MU2Y@1224|Proteobacteria,2TQZ6@28211|Alphaproteobacteria,2K20D@204457|Sphingomonadales 204457|Sphingomonadales EQ PFAM Hydantoinase oxoprolinase - - 3.5.2.14 ko:K01473 ko00330,ko01100,map00330,map01100 - R03187 RC00632 ko00000,ko00001,ko01000 - - - Hydant_A_N,Hydantoinase_A k59_755956_1 1168065.DOK_00370 7.01e-72 232.0 COG1752@1|root,COG1752@2|Bacteria,1N5SK@1224|Proteobacteria,1RSDG@1236|Gammaproteobacteria 1236|Gammaproteobacteria S esterase of the alpha-beta hydrolase superfamily - - - - - - - - - - - - DUF3336,Patatin k59_1548490_1 298654.FraEuI1c_4872 2.38e-79 247.0 COG4608@1|root,COG4608@2|Bacteria,2H4BW@201174|Actinobacteria,4ERXF@85013|Frankiales 201174|Actinobacteria E Belongs to the ABC transporter superfamily appF - - ko:K02032,ko:K10823 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00239,M00439 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 - - ABC_tran,oligo_HPY k59_305817_1 1049564.TevJSym_ac01200 1.6e-09 66.2 COG0443@1|root,COG0443@2|Bacteria,1MVEN@1224|Proteobacteria,1RMDD@1236|Gammaproteobacteria,1J4HD@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O Heat shock 70 kDa protein dnaK GO:0000166,GO:0000988,GO:0000989,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008144,GO:0008150,GO:0008270,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010033,GO:0010556,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0016989,GO:0017076,GO:0017111,GO:0019219,GO:0019222,GO:0022607,GO:0030554,GO:0031323,GO:0031326,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033554,GO:0034620,GO:0035639,GO:0035966,GO:0035967,GO:0036094,GO:0042221,GO:0043167,GO:0043168,GO:0043169,GO:0043531,GO:0043933,GO:0044085,GO:0044183,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0051171,GO:0051252,GO:0051716,GO:0060255,GO:0061077,GO:0065003,GO:0065007,GO:0070887,GO:0071310,GO:0071840,GO:0071944,GO:0080090,GO:0097159,GO:0097367,GO:0140110,GO:1901265,GO:1901363,GO:1903506,GO:2001141 - ko:K04043 ko03018,ko04212,ko05152,map03018,map04212,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 1.A.33.1 - - HSP70 k59_981249_1 293826.Amet_2237 1.9e-42 153.0 COG4974@1|root,COG4974@2|Bacteria,1TR57@1239|Firmicutes,24ACW@186801|Clostridia,36JNY@31979|Clostridiaceae 186801|Clostridia L Phage integrase, N-terminal SAM-like domain - - - - - - - - - - - - Phage_int_SAM_4,Phage_integrase k59_1548492_1 76869.PputGB1_2516 1.61e-08 59.7 COG1459@1|root,COG1459@2|Bacteria,1N8FA@1224|Proteobacteria,1RXYV@1236|Gammaproteobacteria,1YWFZ@136845|Pseudomonas putida group 1236|Gammaproteobacteria U type II secretion system protein gspF - - ko:K02455 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - T2SSF k59_529260_1 76114.ebA5984 1.37e-92 277.0 COG0024@1|root,COG0024@2|Bacteria,1MU99@1224|Proteobacteria,2VH2K@28216|Betaproteobacteria,2KUH5@206389|Rhodocyclales 206389|Rhodocyclales J Methionine aminopeptidase map - 3.4.11.18 ko:K01265 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M24 k59_1264141_1 237368.SCABRO_01631 8.95e-150 444.0 COG3957@1|root,COG3957@2|Bacteria,2IWYJ@203682|Planctomycetes 203682|Planctomycetes G D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase - - - - - - - - - - - - XFP,XFP_C,XFP_N k59_700553_1 1121921.KB898707_gene1257 5.34e-46 155.0 COG3637@1|root,COG3637@2|Bacteria,1RHVI@1224|Proteobacteria,1S6UY@1236|Gammaproteobacteria,2PP0E@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria M Outer membrane protein beta-barrel domain - - - - - - - - - - - - OMP_b-brl,OmpA_membrane k59_1433819_1 1117647.M5M_06760 3.77e-56 197.0 COG4206@1|root,COG4206@2|Bacteria,1QUGQ@1224|Proteobacteria,1T241@1236|Gammaproteobacteria,1J4Z0@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H COG1629 Outer membrane receptor proteins, mostly Fe transport - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_1548503_1 317025.Tcr_0977 2.76e-54 183.0 COG0530@1|root,COG0530@2|Bacteria,1MU3R@1224|Proteobacteria,1RMRD@1236|Gammaproteobacteria,45ZX2@72273|Thiotrichales 72273|Thiotrichales P PFAM sodium calcium exchanger - - - ko:K07301 - - - - ko00000,ko02000 2.A.19.5 - - Na_Ca_ex k59_248211_1 1229909.NSED_01890 4.24e-115 342.0 COG1866@1|root,arCOG06073@2157|Archaea,41SE5@651137|Thaumarchaeota 651137|Thaumarchaeota C Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA pckA - 4.1.1.49 ko:K01610 ko00010,ko00020,ko00620,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00710,map01100,map01110,map01120,map01130,map01200 M00003,M00170 R00341 RC00002,RC02741 ko00000,ko00001,ko00002,ko01000 - - - PEPCK_ATP k59_812934_2 497964.CfE428DRAFT_0418 1.5e-19 87.4 COG1573@1|root,COG1573@2|Bacteria,46SSB@74201|Verrucomicrobia 74201|Verrucomicrobia L TIGRFAM phage SPO1 DNA polymerase-related protein - - 3.2.2.27 ko:K21929 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - UDG k59_1493382_2 1396141.BATP01000037_gene3529 7.43e-53 174.0 COG0110@1|root,COG0110@2|Bacteria,46XE8@74201|Verrucomicrobia,2IVN2@203494|Verrucomicrobiae 203494|Verrucomicrobiae S Hexapeptide repeat of succinyl-transferase - - - - - - - - - - - - - k59_1493382_3 926567.TheveDRAFT_1423 1.26e-05 54.7 COG1215@1|root,COG1215@2|Bacteria,3TAGS@508458|Synergistetes 508458|Synergistetes M glycosyl transferase family 2 - - - - - - - - - - - - Glyco_tranf_2_3 k59_1718611_2 436308.Nmar_1054 3.73e-15 74.7 COG1855@1|root,arCOG04116@2157|Archaea,41SX0@651137|Thaumarchaeota 651137|Thaumarchaeota S Large family of predicted nucleotide-binding domains - - - ko:K06865 - - - - ko00000 - - - KH_1,T2SSE k59_1493383_1 298655.KI912266_gene4406 2.5e-23 99.8 COG1647@1|root,COG1647@2|Bacteria,2GM1Y@201174|Actinobacteria,4ETTX@85013|Frankiales 201174|Actinobacteria S Serine aminopeptidase, S33 yvaK - 3.1.1.1 ko:K03928 - - - - ko00000,ko01000 - - - Hydrolase_4 k59_1493383_2 1210884.HG799462_gene9008 0.000252 43.1 COG1641@1|root,COG1641@2|Bacteria,2IXMJ@203682|Planctomycetes 203682|Planctomycetes S Belongs to the LarC family - - 4.99.1.12 ko:K09121 - - - - ko00000,ko01000 - - - DUF111 k59_756731_1 867845.KI911784_gene3292 1.5e-45 148.0 COG2343@1|root,COG2343@2|Bacteria,2G79F@200795|Chloroflexi,377I0@32061|Chloroflexia 32061|Chloroflexia S Domain of unknown function (DUF427) - - - - - - - - - - - - NTP_transf_9 k59_23977_1 1131266.ARWQ01000006_gene253 6.13e-49 169.0 COG0652@1|root,arCOG04767@2157|Archaea 2157|Archaea G Peptidyl-prolyl cis-trans isomerase ppiA - 2.4.99.18,5.2.1.8 ko:K01802,ko:K03767,ko:K03768,ko:K07151 ko00510,ko00513,ko01100,ko01503,ko04141,ko04217,map00510,map00513,map01100,map01503,map04141,map04217 M00072 R04216,R05976 RC00005,RC00482 ko00000,ko00001,ko00002,ko01000,ko01003,ko03110,ko04147 - GT66 - Pro_isomerase k59_872093_1 983917.RGE_40440 4.98e-21 98.2 COG0115@1|root,COG0147@1|root,COG0115@2|Bacteria,COG0147@2|Bacteria,1MVBJ@1224|Proteobacteria,2VHXV@28216|Betaproteobacteria,1KJ4R@119065|unclassified Burkholderiales 28216|Betaproteobacteria EH chorismate binding enzyme pabB - 2.6.1.85,4.1.3.38 ko:K01665,ko:K03342 ko00790,map00790 - R01716,R05553 RC00010,RC01418,RC01843,RC02148 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_4,Chorismate_bind k59_1041835_1 502025.Hoch_3278 1.29e-22 98.2 COG0745@1|root,COG1340@1|root,COG1352@1|root,COG2201@1|root,COG2202@1|root,COG2203@1|root,COG3829@1|root,COG4191@1|root,COG0745@2|Bacteria,COG1340@2|Bacteria,COG1352@2|Bacteria,COG2201@2|Bacteria,COG2202@2|Bacteria,COG2203@2|Bacteria,COG3829@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,43BKN@68525|delta/epsilon subdivisions,2X6YR@28221|Deltaproteobacteria 28221|Deltaproteobacteria T Histidine kinase A domain protein - - - - - - - - - - - - DUF3365,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg k59_872098_1 1385517.N800_01790 4.78e-35 138.0 COG4770@1|root,COG4770@2|Bacteria,1P6RE@1224|Proteobacteria,1RM95@1236|Gammaproteobacteria,1X2ZC@135614|Xanthomonadales 135614|Xanthomonadales I carboxylase - - 6.4.1.4 ko:K01968 ko00280,ko01100,map00280,map01100 M00036 R04138 RC00367,RC00942 ko00000,ko00001,ko00002,ko01000 - - - Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2 k59_1549668_1 247490.KSU1_D0754 6.17e-71 227.0 COG3039@1|root,COG3039@2|Bacteria 2|Bacteria L Transposase - - - - - - - - - - - - DDE_Tnp_1,DDE_Tnp_1_5 k59_529983_1 1122137.AQXF01000003_gene2332 4.46e-38 135.0 COG1729@1|root,COG1729@2|Bacteria 2|Bacteria S protein trimerization cpoB - - - - - - - - - - - TPR_16,TPR_6,TolA_bind_tri k59_701653_1 351348.Maqu_1404 1.6e-21 90.9 COG0597@1|root,COG0597@2|Bacteria,1RGV9@1224|Proteobacteria,1S60E@1236|Gammaproteobacteria 1236|Gammaproteobacteria M This protein specifically catalyzes the removal of signal peptides from prolipoproteins lspA - 3.4.23.36 ko:K03101 ko03060,map03060 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_A8 k59_701653_2 243233.MCA0086 1.89e-31 116.0 COG4968@1|root,COG4968@2|Bacteria,1N6QE@1224|Proteobacteria,1SCBS@1236|Gammaproteobacteria,1XFP2@135618|Methylococcales 135618|Methylococcales U Type IV minor pilin ComP, DNA uptake sequence receptor - - - ko:K02655 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - ComP_DUS,N_methyl k59_756740_1 28258.KP05_07095 3.22e-12 66.6 COG0325@1|root,COG0325@2|Bacteria,1MWN7@1224|Proteobacteria,1RNPM@1236|Gammaproteobacteria,1XJ5Q@135619|Oceanospirillales 135619|Oceanospirillales S Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis - - - ko:K06997 - - - - ko00000 - - - Ala_racemase_N k59_756740_2 1235457.C404_18075 8.2e-07 52.0 COG0345@1|root,COG0345@2|Bacteria,1R5J1@1224|Proteobacteria,2VJD1@28216|Betaproteobacteria,1JZPH@119060|Burkholderiaceae 28216|Betaproteobacteria E Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline proC - 1.5.1.2 ko:K00286 ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230 M00015 R01248,R01251,R03291,R03293 RC00054,RC00083 ko00000,ko00001,ko00002,ko01000 - - - F420_oxidored,P5CR_dimer k59_23999_1 436308.Nmar_0719 3.51e-120 351.0 COG0601@1|root,arCOG00751@2157|Archaea,41S7B@651137|Thaumarchaeota 651137|Thaumarchaeota P inner membrane component - - - ko:K02033 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1 k59_23999_2 436308.Nmar_0718 3.76e-36 134.0 COG1173@1|root,arCOG00749@2157|Archaea,41SFE@651137|Thaumarchaeota 651137|Thaumarchaeota P inner membrane component - - - ko:K02034 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1 k59_1549691_1 1454004.AW11_02752 3.34e-33 127.0 COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,2VHRB@28216|Betaproteobacteria,1KQU1@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria V AAA domain, putative AbiEii toxin, Type IV TA system - - - ko:K01990,ko:K13926 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_3,ABC_tran k59_1549691_2 1123393.KB891332_gene2690 1.88e-81 253.0 COG0842@1|root,COG0842@2|Bacteria,1MW5R@1224|Proteobacteria,2VKHP@28216|Betaproteobacteria,1KSX0@119069|Hydrogenophilales 119069|Hydrogenophilales V ABC-2 family transporter protein - - - - - - - - - - - - ABC2_membrane_3 k59_24009_1 1229909.NSED_08990 3.51e-30 110.0 COG0636@1|root,arCOG06776@2157|Archaea 2157|Archaea C ATP synthase subunit C - - - ko:K02110,ko:K02124 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157,M00159 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1,3.A.2.2,3.A.2.3 - - ATP-synt_C k59_24009_2 436308.Nmar_1687 3.32e-44 146.0 COG1781@1|root,arCOG04229@2157|Archaea,41SJT@651137|Thaumarchaeota 651137|Thaumarchaeota F Involved in allosteric regulation of aspartate carbamoyltransferase pyrI - - ko:K00610 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R01397 RC00064,RC02850 ko00000,ko00001,ko00002 - - - PyrI,PyrI_C k59_709944_2 1415778.JQMM01000001_gene869 1.17e-54 182.0 COG1181@1|root,COG1181@2|Bacteria,1MUTB@1224|Proteobacteria,1RMTM@1236|Gammaproteobacteria,1J4MW@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria F Belongs to the D-alanine--D-alanine ligase family ddl - 6.3.2.4 ko:K01921 ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502 - R01150 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Dala_Dala_lig_C,Dala_Dala_lig_N k59_1440754_2 203122.Sde_2353 4.65e-86 273.0 COG3383@1|root,COG3383@2|Bacteria,1QX06@1224|Proteobacteria 1224|Proteobacteria C Molybdopterin oxidoreductase Fe4S4 domain - - - - - - - - - - - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding k59_1049633_1 1123070.KB899250_gene555 1.22e-61 214.0 COG4581@1|root,COG4581@2|Bacteria,46STC@74201|Verrucomicrobia,2ITV9@203494|Verrucomicrobiae 203494|Verrucomicrobiae L Domain of unknown function (DUF3516) - - - - - - - - - - - - DEAD,DUF3516,Helicase_C k59_1725940_1 1033737.CAEV01000060_gene3613 6.66e-58 191.0 COG3959@1|root,COG3959@2|Bacteria,1TT51@1239|Firmicutes,247IK@186801|Clostridia,36DP2@31979|Clostridiaceae 186801|Clostridia G Transketolase tktA - 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 - - - Transketolase_N k59_1725940_2 1235799.C818_01574 3.41e-26 106.0 COG3958@1|root,COG3958@2|Bacteria,1V0K5@1239|Firmicutes,24914@186801|Clostridia,27IMD@186928|unclassified Lachnospiraceae 186801|Clostridia G overlaps another CDS with the same product name - - - - - - - - - - - - Transket_pyr,Transketolase_C k59_1778509_1 471853.Bcav_1686 1.12e-30 120.0 COG1052@1|root,COG1052@2|Bacteria,2I2IC@201174|Actinobacteria 201174|Actinobacteria CH D-isomer specific 2-hydroxyacid dehydrogenase - - 1.1.1.26,1.1.1.399,1.1.1.95 ko:K00015,ko:K00058 ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200,map01230 M00020 R00717,R01388,R01513 RC00031,RC00042 ko00000,ko00001,ko00002,ko01000,ko04147 - - - 2-Hacid_dh,2-Hacid_dh_C k59_1501787_1 1131553.JIBI01000012_gene833 8.21e-92 277.0 COG1028@1|root,COG1028@2|Bacteria,1Q7EW@1224|Proteobacteria,2VSPV@28216|Betaproteobacteria 28216|Betaproteobacteria IQ KR domain - - 1.1.1.47 ko:K00034 ko00030,ko01120,ko01200,map00030,map01120,map01200 - R01520,R01521 RC00066 ko00000,ko00001,ko01000 - - - adh_short_C2 k59_1328028_1 402777.KB235904_gene3488 9.51e-77 257.0 COG0642@1|root,COG0745@1|root,COG0784@1|root,COG0745@2|Bacteria,COG0784@2|Bacteria,COG2205@2|Bacteria,1G09B@1117|Cyanobacteria,1H7T9@1150|Oscillatoriales 1117|Cyanobacteria T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - GAF_2,HATPase_c,HisKA,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg k59_143721_1 998088.B565_3980 6.06e-61 196.0 COG0805@1|root,COG0805@2|Bacteria,1MVAY@1224|Proteobacteria,1RPRN@1236|Gammaproteobacteria,1Y3GC@135624|Aeromonadales 135624|Aeromonadales U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides tatC - - ko:K03118 ko03060,ko03070,map03060,map03070 M00336 - - ko00000,ko00001,ko00002,ko02044 2.A.64 - - TatC k59_1271267_1 264462.Bd1236 1.18e-44 149.0 COG0783@1|root,COG0783@2|Bacteria,1RAC5@1224|Proteobacteria,42TUS@68525|delta/epsilon subdivisions,2MT2K@213481|Bdellovibrionales,2X5NM@28221|Deltaproteobacteria 213481|Bdellovibrionales P Ferritin-like domain - - - ko:K04047 - - - - ko00000,ko03036 - - - Ferritin k59_1271267_2 870187.Thini_3452 1.08e-78 244.0 COG0583@1|root,COG0583@2|Bacteria,1MVA1@1224|Proteobacteria,1RPAJ@1236|Gammaproteobacteria,460V0@72273|Thiotrichales 72273|Thiotrichales K Bacterial regulatory helix-turn-helix protein, lysR family - - - ko:K04761 ko02026,map02026 - - - ko00000,ko00001,ko03000 - - - HTH_1,LysR_substrate k59_1160442_1 153721.MYP_3871 8.21e-30 117.0 COG4313@1|root,COG4313@2|Bacteria,4NW4N@976|Bacteroidetes,47WR2@768503|Cytophagia 976|Bacteroidetes C Putative MetA-pathway of phenol degradation - - - - - - - - - - - - Phenol_MetA_deg k59_709963_1 187272.Mlg_2601 3.89e-210 592.0 COG2079@1|root,COG2079@2|Bacteria,1MUIG@1224|Proteobacteria,1RPQN@1236|Gammaproteobacteria,1WWIP@135613|Chromatiales 135613|Chromatiales S 2-methylcitrate dehydratase prpD - 4.2.1.79 ko:K01720 ko00640,map00640 - R04424 RC01152 ko00000,ko00001,ko01000 - - - MmgE_PrpD k59_199707_1 36809.MAB_4139 6.73e-06 49.3 COG0640@1|root,COG0640@2|Bacteria,2IQH9@201174|Actinobacteria,23APX@1762|Mycobacteriaceae 201174|Actinobacteria K helix_turn_helix, Arsenical Resistance Operon Repressor - - - ko:K03892 - - - - ko00000,ko03000 - - - HTH_20,HTH_5 k59_199707_2 102129.Lepto7375DRAFT_7042 6.49e-39 139.0 COG0226@1|root,COG0226@2|Bacteria,1G0JS@1117|Cyanobacteria,1H9HY@1150|Oscillatoriales 1117|Cyanobacteria P Phosphate ABC transporter substrate-binding protein - - - ko:K02040 ko02010,ko02020,ko05152,map02010,map02020,map05152 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - PBP_like_2 k59_932470_1 314264.ROS217_17297 9.4e-19 90.5 COG3164@1|root,COG3164@2|Bacteria,1MVDY@1224|Proteobacteria,2TSGG@28211|Alphaproteobacteria,46NQQ@74030|Roseovarius 28211|Alphaproteobacteria S Protein of unknown function MA20_30770 - - - - - - - - - - - AsmA_2,DUF3971 k59_372101_1 1229909.NSED_06255 4.1e-69 218.0 COG0473@1|root,arCOG01163@2157|Archaea,41SAA@651137|Thaumarchaeota 651137|Thaumarchaeota C Isocitrate isopropylmalate dehydrogenase - - 1.1.1.85 ko:K00052 ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230 M00432,M00535 R00994,R04426,R10052 RC00084,RC00417,RC03036 br01601,ko00000,ko00001,ko00002,ko01000 - - - Iso_dh k59_988199_1 880070.Cycma_2483 7.1e-51 170.0 COG3279@1|root,COG3279@2|Bacteria,4NIXT@976|Bacteroidetes,47Q12@768503|Cytophagia 976|Bacteroidetes K Two component transcriptional regulator, LytTR family - - - - - - - - - - - - LytTR,Response_reg k59_1388658_1 983920.Y88_3806 9.06e-98 293.0 COG4569@1|root,COG4569@2|Bacteria,1MV23@1224|Proteobacteria,2U26H@28211|Alphaproteobacteria,2K23D@204457|Sphingomonadales 204457|Sphingomonadales H Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD( ) and coenzyme A. Is the final enzyme in the meta- cleavage pathway for the degradation of aromatic compounds - - 1.2.1.10 ko:K04073 ko00360,ko00362,ko00620,ko00621,ko00622,ko00650,ko01100,ko01120,ko01220,map00360,map00362,map00620,map00621,map00622,map00650,map01100,map01120,map01220 M00545,M00569 R00228,R01172 RC00004,RC00184,RC01195 br01602,ko00000,ko00001,ko00002,ko01000 - - - AcetDehyd-dimer,Semialdhyde_dh k59_1388658_2 1240350.AMZE01000075_gene4403 1.83e-29 111.0 COG3971@1|root,COG3971@2|Bacteria,1MVVV@1224|Proteobacteria,1RMZ4@1236|Gammaproteobacteria 1236|Gammaproteobacteria Q hydratase - - 4.2.1.132,4.2.1.80 ko:K18364 ko00362,ko00621,ko00622,ko01100,ko01120,ko01220,map00362,map00621,map00622,map01100,map01120,map01220 M00569 R02601,R05864 RC00750,RC02676 br01602,ko00000,ko00001,ko00002,ko01000 - - - FAA_hydrolase k59_1217994_1 1415779.JOMH01000001_gene2449 1.74e-25 109.0 COG4105@1|root,COG4105@2|Bacteria,1QVQ9@1224|Proteobacteria,1RSIG@1236|Gammaproteobacteria,1X5V0@135614|Xanthomonadales 135614|Xanthomonadales S Tetratricopeptide repeat - - - - - - - - - - - - TPR_16,TPR_6 k59_988202_1 702113.PP1Y_AT5089 8.89e-64 220.0 COG1196@1|root,COG1196@2|Bacteria,1MUAQ@1224|Proteobacteria,2TRQG@28211|Alphaproteobacteria,2K02F@204457|Sphingomonadales 204457|Sphingomonadales D Required for chromosome condensation and partitioning smc - - ko:K03529 - - - - ko00000,ko03036 - - - SMC_N k59_1049669_1 1454004.AW11_01122 8.99e-15 68.6 2E70X@1|root,331JP@2|Bacteria,1N81S@1224|Proteobacteria,2W4A4@28216|Betaproteobacteria 28216|Betaproteobacteria S Putative F0F1-ATPase subunit Ca2+/Mg2+ transporter - - - - - - - - - - - - ATPase_gene1 k59_1049669_2 697282.Mettu_0381 2.49e-52 172.0 COG0356@1|root,COG0356@2|Bacteria,1RBEV@1224|Proteobacteria,1T170@1236|Gammaproteobacteria,1XEY5@135618|Methylococcales 135618|Methylococcales C it plays a direct role in the translocation of protons across the membrane - - - ko:K02108 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko03110 3.A.2.1 - - ATP-synt_A k59_315401_1 316407.85674300 1.91e-183 517.0 COG2271@1|root,COG2271@2|Bacteria,1QV3V@1224|Proteobacteria,1T27B@1236|Gammaproteobacteria,3XN87@561|Escherichia 1236|Gammaproteobacteria P response to oxidative stress yaaU GO:0005575,GO:0005623,GO:0005886,GO:0006950,GO:0006979,GO:0008150,GO:0016020,GO:0044464,GO:0050896,GO:0071944 - ko:K08368 - - - - ko00000,ko02000 2.A.1 - - Sugar_tr k59_762574_1 1122139.KB907870_gene1026 3.48e-108 323.0 COG0304@1|root,COG0304@2|Bacteria,1MU1X@1224|Proteobacteria,1RMDE@1236|Gammaproteobacteria,1XHMY@135619|Oceanospirillales 135619|Oceanospirillales IQ catalyzes a condensation reaction in fatty acid biosynthesis addition of an acyl acceptor of two carbons from malonyl-ACP fabB - 2.3.1.41 ko:K00647 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119 RC00039,RC02728,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Ketoacyl-synt_C,ketoacyl-synt k59_988212_2 1122194.AUHU01000003_gene2183 4.68e-100 304.0 COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,1RNAM@1236|Gammaproteobacteria,4658T@72275|Alteromonadaceae 1236|Gammaproteobacteria G COG1593 TRAP-type C4-dicarboxylate transport system, large permease component - - - - - - - - - - - - DctM k59_424703_1 1345023.M467_10875 3.66e-34 126.0 COG4122@1|root,COG4122@2|Bacteria,1V1JR@1239|Firmicutes,4HHW6@91061|Bacilli 91061|Bacilli S WbqC-like protein family - - - - - - - - - - - - WbqC k59_424703_2 631362.Thi970DRAFT_02878 1.32e-36 136.0 28HYD@1|root,2Z83U@2|Bacteria,1R5TY@1224|Proteobacteria,1RQN8@1236|Gammaproteobacteria,1WZHG@135613|Chromatiales 135613|Chromatiales S Sulfotransferase family - - - - - - - - - - - - Sulfotransfer_3 k59_596832_1 666681.M301_1368 1.52e-15 75.9 COG0830@1|root,COG0830@2|Bacteria,1MW8Q@1224|Proteobacteria,2VRF6@28216|Betaproteobacteria,2KMCA@206350|Nitrosomonadales 206350|Nitrosomonadales O Required for maturation of urease via the functional incorporation of the urease nickel metallocenter ureF - - ko:K03188 - - - - ko00000 - - - UreF k59_596832_2 1131269.AQVV01000006_gene441 6.95e-11 61.6 COG2371@1|root,COG2371@2|Bacteria 2|Bacteria O enzyme active site formation ureE - - ko:K03187 - - - - ko00000 - - - UreE_C,UreE_N k59_199743_1 85643.Tmz1t_1226 3.76e-73 226.0 COG0741@1|root,COG0741@2|Bacteria,1R666@1224|Proteobacteria,2VHI4@28216|Betaproteobacteria,2KW2B@206389|Rhodocyclales 206389|Rhodocyclales M COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains) - - - - - - - - - - - - SLT k59_1271298_1 436308.Nmar_0030 1.64e-05 47.0 arCOG06534@1|root,arCOG06534@2157|Archaea 2157|Archaea S acid phosphatase activity - - - - - - - - - - - - He_PIG k59_762582_1 28532.XP_010555223.1 3.37e-94 292.0 COG1052@1|root,KOG0069@2759|Eukaryota,37ISZ@33090|Viridiplantae,3GC69@35493|Streptophyta,3HYUW@3699|Brassicales 35493|Streptophyta C Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family HPR GO:0001101,GO:0003674,GO:0003676,GO:0003723,GO:0003727,GO:0003824,GO:0005488,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005777,GO:0005829,GO:0006950,GO:0007154,GO:0008150,GO:0008152,GO:0008187,GO:0008266,GO:0008465,GO:0009314,GO:0009414,GO:0009415,GO:0009416,GO:0009507,GO:0009536,GO:0009605,GO:0009628,GO:0009853,GO:0009854,GO:0009987,GO:0009991,GO:0010035,GO:0016491,GO:0016614,GO:0016616,GO:0016618,GO:0030267,GO:0031668,GO:0033554,GO:0042221,GO:0042579,GO:0042631,GO:0043094,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0048046,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0071214,GO:0071229,GO:0071462,GO:0071478,GO:0071482,GO:0071496,GO:0097159,GO:0104004,GO:1901363,GO:1901700,GO:1901701 - ko:K15893 ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200 M00532 R01388 RC00031 ko00000,ko00001,ko00002 - - - 2-Hacid_dh,2-Hacid_dh_C k59_1049701_1 670292.JH26_21200 1.51e-09 60.5 COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TQQ9@28211|Alphaproteobacteria,1JRB9@119045|Methylobacteriaceae 28211|Alphaproteobacteria T PFAM response regulator receiver - - - - - - - - - - - - HATPase_c,HisKA,PAS_4,Response_reg k59_1725984_1 583345.Mmol_2285 3.03e-56 187.0 COG0773@1|root,COG0773@2|Bacteria,1MUC5@1224|Proteobacteria,2VIX5@28216|Betaproteobacteria,2KMB0@206350|Nitrosomonadales 206350|Nitrosomonadales M Reutilizes the intact tripeptide L-alanyl-gamma-D- glutamyl-meso-diaminopimelate by linking it to UDP-N- acetylmuramate mpl - 6.3.2.45 ko:K02558 - - - - ko00000,ko01000 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_1725984_2 398580.Dshi_1678 2.88e-13 70.9 2CDFF@1|root,32RXP@2|Bacteria,1N26W@1224|Proteobacteria,2UDNJ@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_1778550_1 1128421.JAGA01000003_gene3679 1.43e-61 214.0 COG5297@1|root,COG5297@2|Bacteria,2NQDB@2323|unclassified Bacteria 2|Bacteria G CBD_II - - 3.2.1.4 ko:K01179 ko00500,ko01100,map00500,map01100 - R06200,R11307,R11308 - ko00000,ko00001,ko01000 - GH5,GH9 - CBM_2,CBM_3,Dockerin_1,Glyco_hydro_9,fn3 k59_1501846_2 1286631.X805_20170 9.77e-16 80.1 COG4966@1|root,COG4966@2|Bacteria,1RH2G@1224|Proteobacteria,2VT5C@28216|Betaproteobacteria,1KMMA@119065|unclassified Burkholderiales 28216|Betaproteobacteria NU Type IV Pilus-assembly protein W - - - ko:K02672 - - - - ko00000,ko02035,ko02044 - - - N_methyl,PilW k59_762589_1 926569.ANT_25980 1.38e-38 142.0 COG1030@1|root,COG1030@2|Bacteria,2G6E2@200795|Chloroflexi 200795|Chloroflexi O NfeD-like C-terminal, partner-binding - - - ko:K07403 - - - - ko00000 - - - CLP_protease,NfeD k59_1161733_2 743720.Psefu_2276 6.61e-45 156.0 COG0428@1|root,COG0428@2|Bacteria,1MWEZ@1224|Proteobacteria,1RNXU@1236|Gammaproteobacteria,1YUVY@136845|Pseudomonas putida group 1236|Gammaproteobacteria P Zinc iron permease zupT GO:0000041,GO:0003674,GO:0005215,GO:0005381,GO:0005384,GO:0005385,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006824,GO:0006826,GO:0006828,GO:0006829,GO:0008150,GO:0008324,GO:0015075,GO:0015086,GO:0015087,GO:0015093,GO:0015318,GO:0015684,GO:0015691,GO:0016020,GO:0022857,GO:0022890,GO:0030001,GO:0034220,GO:0034755,GO:0044464,GO:0046873,GO:0046915,GO:0051179,GO:0051234,GO:0055085,GO:0070574,GO:0070838,GO:0071421,GO:0071577,GO:0071944,GO:0072509,GO:0072511,GO:0098655,GO:0098660,GO:0098662,GO:1903874 - ko:K07238 - - - - ko00000,ko02000 2.A.5.5 - iECIAI39_1322.ECIAI39_3536 Zip k59_821423_2 97139.C824_03027 6.14e-06 48.5 COG1461@1|root,COG1461@2|Bacteria,1TQMX@1239|Firmicutes,247XI@186801|Clostridia,36E63@31979|Clostridiaceae 186801|Clostridia S DAK2 domain fusion protein YloV yloV - - ko:K07030 - - - - ko00000 - - - Dak1_2,Dak2 k59_1390017_1 1123368.AUIS01000023_gene909 4.34e-13 68.2 COG2143@1|root,COG2143@2|Bacteria,1NP6X@1224|Proteobacteria,1SBRN@1236|Gammaproteobacteria 1236|Gammaproteobacteria O Thioredoxin-like domain - - - - - - - - - - - - Thioredoxin_2 k59_316826_1 1120953.AUBH01000002_gene1453 1.24e-108 348.0 COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1145@1|root,COG1146@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1145@2|Bacteria,COG1146@2|Bacteria,1MVM0@1224|Proteobacteria,1RNNX@1236|Gammaproteobacteria,464U2@72275|Alteromonadaceae 1236|Gammaproteobacteria C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin - - 1.2.7.1 ko:K03737 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00173,M00307 R01196,R10866 RC00004,RC02742 br01601,ko00000,ko00001,ko00002,ko01000 - - - EKR,Fer4,Fer4_13,Fer4_16,Fer4_6,PFOR_II,POR,POR_N,TPP_enzyme_C k59_1503135_1 880071.Fleli_0067 6.36e-58 188.0 COG0388@1|root,COG0388@2|Bacteria,4NEME@976|Bacteroidetes,47JFJ@768503|Cytophagia 976|Bacteroidetes S PFAM Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase pabB - 3.5.1.53 ko:K12251 ko00330,ko01100,map00330,map01100 - R01152 RC00096 ko00000,ko00001,ko01000 - - - CN_hydrolase k59_1503135_2 1415778.JQMM01000001_gene1011 1.3e-15 75.5 COG2957@1|root,COG2957@2|Bacteria,1MX65@1224|Proteobacteria,1RMF1@1236|Gammaproteobacteria,1J511@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Belongs to the agmatine deiminase family aguA - 3.5.3.12 ko:K10536 ko00330,ko01100,map00330,map01100 - R01416 RC00177 ko00000,ko00001,ko01000 - - - PAD_porph k59_1329024_1 1278073.MYSTI_04512 1.63e-62 221.0 COG1858@1|root,COG2706@1|root,COG3391@1|root,COG1858@2|Bacteria,COG2706@2|Bacteria,COG3391@2|Bacteria,1R66T@1224|Proteobacteria 1224|Proteobacteria C amine dehydrogenase activity - - - - - - - - - - - - Lactonase k59_711390_1 1121887.AUDK01000001_gene461 1.97e-105 318.0 COG4733@1|root,COG5492@1|root,COG4733@2|Bacteria,COG5492@2|Bacteria,4PNDB@976|Bacteroidetes,1HZQB@117743|Flavobacteriia,2NWFK@237|Flavobacterium 976|Bacteroidetes N Right handed beta helix region - - - - - - - - - - - - Beta_helix,Big_2,DUF4990 k59_481225_1 309801.trd_0033 1.65e-40 154.0 COG1253@1|root,COG1253@2|Bacteria,2G6D1@200795|Chloroflexi,27Y6B@189775|Thermomicrobia 189775|Thermomicrobia S Transporter associated domain - - - - - - - - - - - - CBS,CorC_HlyC k59_1503149_1 1313172.YM304_21490 6.63e-85 271.0 COG0556@1|root,COG0556@2|Bacteria,2GJ03@201174|Actinobacteria,4CMWE@84992|Acidimicrobiia 84992|Acidimicrobiia L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage uvrB - - ko:K03702 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - Helicase_C,ResIII,UVR,UvrB k59_1161766_1 1276756.AUEX01000029_gene2189 1.41e-34 137.0 COG0045@1|root,COG1042@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,1MW98@1224|Proteobacteria,2VI9R@28216|Betaproteobacteria 28216|Betaproteobacteria C CoA-binding domain protein - - - - - - - - - - - - ATP-grasp_5,Acetyltransf_1,Acetyltransf_3,Acetyltransf_4,CoA_binding_2,Succ_CoA_lig k59_933516_1 1201288.M900_1457 1.1e-13 75.9 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2MSRN@213481|Bdellovibrionales,2WJ8D@28221|Deltaproteobacteria 213481|Bdellovibrionales V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K03296 - - - - ko00000 2.A.6.2 - - ACR_tran k59_711416_1 450851.PHZ_c1001 8.76e-31 119.0 COG1680@1|root,COG1680@2|Bacteria,1MVPR@1224|Proteobacteria,2TRWZ@28211|Alphaproteobacteria,2KFVB@204458|Caulobacterales 204458|Caulobacterales V beta-lactamase - - - - - - - - - - - - Beta-lactamase k59_1390064_1 519989.ECTPHS_00060 1.8e-134 405.0 COG0542@1|root,COG0542@2|Bacteria,1MURH@1224|Proteobacteria,1RN55@1236|Gammaproteobacteria,1WWC8@135613|Chromatiales 135613|Chromatiales O Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE clpB - - ko:K03695 ko04213,map04213 - - - ko00000,ko00001,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N k59_1614358_1 436308.Nmar_0840 7.31e-27 102.0 COG1545@1|root,arCOG01289@2157|Archaea,41SWD@651137|Thaumarchaeota 651137|Thaumarchaeota S nucleic-acid-binding protein containing a Zn-ribbon - - - ko:K07068 - - - - ko00000 - - - - k59_1614358_2 436308.Nmar_0837 1.85e-84 254.0 COG1591@1|root,arCOG00919@2157|Archaea,41SQP@651137|Thaumarchaeota 651137|Thaumarchaeota L A structure-specific endonuclease that resolves Holliday junction (HJ) intermediates during genetic recombination. Cleaves 4-way DNA junctions introducing paired nicks in opposing strands, leaving a 5'-terminal phosphate and a 3'-terminal hydroxyl group that are ligated to produce recombinant products - - - - - - - - - - - - Hjc k59_425718_1 1502724.FF80_00529 1.95e-111 327.0 COG2875@1|root,COG2875@2|Bacteria,1MVYY@1224|Proteobacteria,2TRU7@28211|Alphaproteobacteria,3N628@45401|Hyphomicrobiaceae 28211|Alphaproteobacteria H Belongs to the precorrin methyltransferase family cobM - 2.1.1.133,2.1.1.271 ko:K05936 ko00860,ko01100,map00860,map01100 - R05181,R05810 RC00003,RC01294,RC02049 ko00000,ko00001,ko01000 - - - TP_methylase k59_881858_1 555793.WSK_0324 1.57e-109 323.0 COG0306@1|root,COG0306@2|Bacteria,1MVXK@1224|Proteobacteria,2TSYI@28211|Alphaproteobacteria,2JZVM@204457|Sphingomonadales 204457|Sphingomonadales P phosphate transporter - - - ko:K03306 - - - - ko00000 2.A.20 - - PHO4 k59_763557_1 1207063.P24_05464 6.97e-43 149.0 COG3703@1|root,COG3703@2|Bacteria,1QA7D@1224|Proteobacteria,2U84Q@28211|Alphaproteobacteria,2JZR9@204441|Rhodospirillales 204441|Rhodospirillales P Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides - - - ko:K07232 - - - - ko00000 - - - ChaC k59_144659_2 1121123.AUAO01000005_gene1803 1.05e-05 50.1 COG1595@1|root,COG1595@2|Bacteria,1MX7T@1224|Proteobacteria,2U5A1@28211|Alphaproteobacteria,2KGEK@204458|Caulobacterales 204458|Caulobacterales K Belongs to the sigma-70 factor family. ECF subfamily - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 k59_1726960_1 522306.CAP2UW1_4189 5.84e-76 238.0 COG4972@1|root,COG4972@2|Bacteria,1MX8P@1224|Proteobacteria,2VH6W@28216|Betaproteobacteria 28216|Betaproteobacteria NU Type IV pilus assembly protein PilM pilM - - ko:K02662 - - - - ko00000,ko02035,ko02044 - - - PilM_2 k59_1503181_1 391587.KAOT1_10631 3.99e-73 246.0 COG3391@1|root,COG4935@1|root,COG3391@2|Bacteria,COG4935@2|Bacteria,4P0CG@976|Bacteroidetes,1I7QI@117743|Flavobacteriia 976|Bacteroidetes O C-terminal domain of CHU protein family - - - - - - - - - - - - CHU_C,CUB,PKD,P_proprotein k59_1560327_1 713586.KB900536_gene952 5.5e-41 148.0 COG0303@1|root,COG0303@2|Bacteria,1MVD5@1224|Proteobacteria,1RMQU@1236|Gammaproteobacteria,1WVYA@135613|Chromatiales 135613|Chromatiales H TIGRFAM molybdenum cofactor synthesis - - 2.10.1.1 ko:K03750 ko00790,ko01100,map00790,map01100 - R09735 RC03462 ko00000,ko00001,ko01000 - - - MoCF_biosynth,MoeA_C,MoeA_N k59_1560327_2 743720.Psefu_3315 0.00032 42.4 COG1714@1|root,COG1714@2|Bacteria,1N7R6@1224|Proteobacteria,1SCCT@1236|Gammaproteobacteria,1YVFN@136845|Pseudomonas putida group 1236|Gammaproteobacteria S PFAM RDD domain containing protein - - - - - - - - - - - - RDD k59_881873_1 555793.WSK_0426 7.12e-35 129.0 COG0624@1|root,COG0624@2|Bacteria,1MVUX@1224|Proteobacteria,2TR5X@28211|Alphaproteobacteria,2K1Z4@204457|Sphingomonadales 204457|Sphingomonadales E Peptidase family M20/M25/M40 - - 3.5.3.9 ko:K02083 ko00230,ko01120,map00230,map01120 - R02423 RC00064 ko00000,ko00001,ko01000,ko01002 - - - M20_dimer,Peptidase_M20,Peptidase_M28 k59_881873_2 555793.WSK_0427 3.64e-48 164.0 COG0075@1|root,COG0075@2|Bacteria,1MWHJ@1224|Proteobacteria,2TQSN@28211|Alphaproteobacteria,2K8FX@204457|Sphingomonadales 204457|Sphingomonadales E Aminotransferase class-V - - 2.6.1.112,2.6.1.44,2.6.1.45,2.6.1.51 ko:K00830,ko:K00839 ko00230,ko00250,ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko04146,map00230,map00250,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200,map04146 M00346,M00532 R00369,R00372,R00585,R00588,R10908 RC00006,RC00008,RC00018,RC03305 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_5 k59_1329062_1 1229909.NSED_00945 1.16e-140 410.0 COG1109@1|root,arCOG00767@2157|Archaea,41S74@651137|Thaumarchaeota 651137|Thaumarchaeota G Belongs to the phosphohexose mutase family - - 5.4.2.2,5.4.2.8 ko:K15778 ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130 M00114 R00959,R01057,R01818,R08639 RC00408 ko00000,ko00001,ko00002,ko01000 - - - PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV k59_90271_1 1249627.D779_3062 1.17e-53 172.0 COG1490@1|root,COG1490@2|Bacteria,1RGTV@1224|Proteobacteria,1S61I@1236|Gammaproteobacteria,1WYB4@135613|Chromatiales 135613|Chromatiales J rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality dtd - - ko:K07560 - - - - ko00000,ko01000,ko03016 - - - Tyr_Deacylase k59_90271_2 83406.HDN1F_30750 1.6e-10 62.4 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,1J4KP@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains glnG GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - ko:K07712 ko02020,map02020 M00497 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_1218997_1 1195246.AGRI_12401 4.86e-62 214.0 COG1629@1|root,COG1629@2|Bacteria,COG4771@2|Bacteria,1MU9K@1224|Proteobacteria,1RMTG@1236|Gammaproteobacteria,4651V@72275|Alteromonadaceae 1236|Gammaproteobacteria P COG1629 Outer membrane receptor proteins, mostly Fe transport - - - - - - - - - - - - Plug,TonB_dep_Rec k59_711454_1 1096930.L284_15835 5.42e-14 70.9 COG1009@1|root,COG1009@2|Bacteria,1MW2M@1224|Proteobacteria,2TQSS@28211|Alphaproteobacteria,2K1DM@204457|Sphingomonadales 204457|Sphingomonadales CP NADH ubiquinone oxidoreductase subunit nuoL - 1.6.5.3 ko:K00341 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - NADH5_C,Proton_antipo_M,Proton_antipo_N k59_711454_2 1088721.NSU_4202 8.33e-246 685.0 COG1008@1|root,COG1008@2|Bacteria,1MV7V@1224|Proteobacteria,2TSNK@28211|Alphaproteobacteria,2K0EQ@204457|Sphingomonadales 204457|Sphingomonadales C NADH ubiquinone oxidoreductase subunit nuoM - 1.6.5.3 ko:K00342 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q5_N,Proton_antipo_M k59_1726972_1 62928.azo2212 1.12e-139 420.0 COG4631@1|root,COG4631@2|Bacteria,1NQSR@1224|Proteobacteria,2VHYR@28216|Betaproteobacteria,2KV6J@206389|Rhodocyclales 206389|Rhodocyclales F COG4631 Xanthine dehydrogenase, molybdopterin-binding subunit B - - 1.17.1.4 ko:K13482 ko00230,ko01100,ko01120,map00230,map01100,map01120 M00546 R01768,R02103 RC00143 ko00000,ko00001,ko00002,ko01000 - - - Ald_Xan_dh_C,Ald_Xan_dh_C2 k59_1669144_1 1096930.L284_21440 1.3e-21 90.9 COG2957@1|root,COG2957@2|Bacteria,1MX65@1224|Proteobacteria,2U0RR@28211|Alphaproteobacteria,2K0B9@204457|Sphingomonadales 204457|Sphingomonadales E Belongs to the agmatine deiminase family - - 3.5.3.12 ko:K10536 ko00330,ko01100,map00330,map01100 - R01416 RC00177 ko00000,ko00001,ko01000 - - - PAD_porph k59_1669144_2 555793.WSK_1474 2.4e-78 250.0 COG2234@1|root,COG2234@2|Bacteria,1MV86@1224|Proteobacteria,2TVJ5@28211|Alphaproteobacteria,2K04D@204457|Sphingomonadales 204457|Sphingomonadales S Peptidase, M28 - - - - - - - - - - - - PA,Peptidase_M28 k59_1503200_1 1004785.AMBLS11_01060 4.9e-49 184.0 COG3250@1|root,COG3250@2|Bacteria,1MVBN@1224|Proteobacteria,1RMER@1236|Gammaproteobacteria,4654R@72275|Alteromonadaceae 1236|Gammaproteobacteria G Belongs to the glycosyl hydrolase 2 family lacZ GO:0000287,GO:0003674,GO:0003824,GO:0004553,GO:0004565,GO:0005488,GO:0005515,GO:0005575,GO:0005975,GO:0005984,GO:0005988,GO:0005990,GO:0008150,GO:0008152,GO:0009056,GO:0009311,GO:0009313,GO:0009341,GO:0009987,GO:0015925,GO:0016052,GO:0016787,GO:0016798,GO:0031420,GO:0032991,GO:0042802,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044262,GO:0044275,GO:0046352,GO:0046872,GO:0071704,GO:1901575,GO:1902494 3.2.1.23 ko:K01190 ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100 - R01105,R01678,R03355,R04783,R06114 RC00049,RC00452 ko00000,ko00001,ko01000 - - iAF1260.b0344,iB21_1397.B21_00302,iECBD_1354.ECBD_3313,iECB_1328.ECB_00298,iECDH1ME8569_1439.ECDH1ME8569_0331,iECD_1391.ECD_00298,iECNA114_1301.ECNA114_0327,iEcDH1_1363.EcDH1_3262,iJO1366.b0344,iJR904.b0344,iY75_1357.Y75_RS01775 Bgal_small_N,DUF4981,Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N k59_763577_2 357808.RoseRS_2550 3.46e-07 54.3 COG0613@1|root,COG0613@2|Bacteria,2G9BU@200795|Chloroflexi,376CR@32061|Chloroflexia 32061|Chloroflexia S SMART phosphoesterase PHP domain protein - - - - - - - - - - - - - k59_598309_1 1535422.ND16A_3771 3.61e-110 339.0 COG0296@1|root,COG0296@2|Bacteria,1QTVN@1224|Proteobacteria,1RQSK@1236|Gammaproteobacteria 1236|Gammaproteobacteria G Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position glgB GO:0000271,GO:0003674,GO:0003824,GO:0003844,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0006073,GO:0006091,GO:0006112,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0015980,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033554,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716,GO:0055114,GO:0071704,GO:1901576 2.4.1.18 ko:K00700 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R02110 - ko00000,ko00001,ko00002,ko01000,ko04147 - CBM48,GH13 iAPECO1_1312.APECO1_3025,iECNA114_1301.ECNA114_3542,iECOK1_1307.ECOK1_3857,iECS88_1305.ECS88_3830,iECSF_1327.ECSF_3253,iLF82_1304.LF82_0837,iNRG857_1313.NRG857_17030,iUTI89_1310.UTI89_C3941 Alpha-amylase,Alpha-amylase_C,CBM_48 k59_933550_1 1122137.AQXF01000006_gene699 2.32e-96 293.0 COG0399@1|root,COG0399@2|Bacteria,1MUPN@1224|Proteobacteria,2TRIQ@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Belongs to the DegT DnrJ EryC1 family - - - - - - - - - - - - DegT_DnrJ_EryC1 k59_1448245_1 640081.Dsui_2814 1.11e-84 270.0 COG0855@1|root,COG0855@2|Bacteria,1MUM3@1224|Proteobacteria,2VHH8@28216|Betaproteobacteria,2KUJF@206389|Rhodocyclales 206389|Rhodocyclales H Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) ppk - 2.7.4.1 ko:K00937 ko00190,ko03018,map00190,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - PP_kinase,PP_kinase_C,PP_kinase_N k59_718544_1 756067.MicvaDRAFT_2506 4.39e-144 451.0 COG1020@1|root,COG1020@2|Bacteria,1G0XE@1117|Cyanobacteria,1H9T8@1150|Oscillatoriales 1117|Cyanobacteria Q Amino acid adenylation domain - - - - - - - - - - - - AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase k59_431387_1 765912.Thimo_3236 5.13e-67 219.0 COG0374@1|root,COG0374@2|Bacteria,1MWFJ@1224|Proteobacteria,1RMC3@1236|Gammaproteobacteria,1WWAQ@135613|Chromatiales 135613|Chromatiales C Belongs to the NiFe NiFeSe hydrogenase large subunit family - - 1.12.99.6 ko:K06281 ko00633,ko01120,map00633,map01120 - R08034 RC00250 ko00000,ko00001,ko01000 - - - NiFeSe_Hases k59_208247_1 1125863.JAFN01000001_gene724 4.66e-51 166.0 COG0745@1|root,COG0745@2|Bacteria,1MU67@1224|Proteobacteria,42N90@68525|delta/epsilon subdivisions,2WJUU@28221|Deltaproteobacteria 28221|Deltaproteobacteria K PFAM response regulator receiver - - - ko:K07665 ko02020,map02020 M00452,M00745 - - ko00000,ko00001,ko00002,ko01504,ko02022 - - - Response_reg,Trans_reg_C k59_208247_2 1125863.JAFN01000001_gene723 1.14e-30 119.0 COG0642@1|root,COG2205@2|Bacteria,1MW8M@1224|Proteobacteria,42QF7@68525|delta/epsilon subdivisions,2WJAU@28221|Deltaproteobacteria 28221|Deltaproteobacteria T Histidine kinase - - 2.7.13.3 ko:K07644 ko02020,map02020 M00452,M00745 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko01504,ko02022 - - - HAMP,HATPase_c,HisKA,PAS_9,Response_reg k59_657281_2 1229909.NSED_07840 1.29e-22 92.0 COG1383@1|root,arCOG01885@2157|Archaea,41SUH@651137|Thaumarchaeota 651137|Thaumarchaeota J ribosomal protein - - - ko:K02962 ko03010,map03010 M00177,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S17e k59_1784868_2 1144672.F966_00451 5.54e-119 353.0 COG0399@1|root,COG0399@2|Bacteria,1MUMJ@1224|Proteobacteria,1RSDY@1236|Gammaproteobacteria,3NKKZ@468|Moraxellaceae 1236|Gammaproteobacteria M Putative transposase - - - - - - - - - - - - Y2_Tnp,Zn_Tnp_IS91 k59_939861_1 1191523.MROS_2090 2.07e-43 159.0 COG5520@1|root,COG5520@2|Bacteria 2|Bacteria M Belongs to the glycosyl hydrolase 30 family - - 3.2.1.136 ko:K15924 - - - - ko00000,ko01000 - GH5 - CBM_2,Glyco_hydr_30_2,Glyco_hydro_30,Glyco_hydro_30C k59_1448264_1 1485544.JQKP01000002_gene1608 3.34e-10 64.3 COG1587@1|root,COG1587@2|Bacteria,1MWZD@1224|Proteobacteria,2VRU9@28216|Betaproteobacteria,44VS4@713636|Nitrosomonadales 28216|Betaproteobacteria H Uroporphyrinogen-III synthase HemD hemD - 4.2.1.75 ko:K01719 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R03165 RC01861 ko00000,ko00001,ko00002,ko01000 - - - HEM4 k59_1448264_2 948565.AFFP02000005_gene474 2.72e-17 81.3 COG0181@1|root,COG0181@2|Bacteria,1MU56@1224|Proteobacteria,1RMQ8@1236|Gammaproteobacteria,1Y6TR@135625|Pasteurellales 135625|Pasteurellales H Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps hemC - 2.5.1.61 ko:K01749 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R00084 RC02317 ko00000,ko00001,ko00002,ko01000 - - - Porphobil_deam,Porphobil_deamC k59_380239_1 517722.AEUE01000001_gene2512 7.3e-72 233.0 COG1232@1|root,COG1232@2|Bacteria,1MX35@1224|Proteobacteria,2TU7I@28211|Alphaproteobacteria,2K14D@204457|Sphingomonadales 204457|Sphingomonadales H Thi4 family - - - - - - - - - - - - Amino_oxidase,NAD_binding_8 k59_1733000_1 237609.PSAKL28_49760 3.14e-27 115.0 COG5009@1|root,COG5009@2|Bacteria,1MU5A@1224|Proteobacteria,1RM7J@1236|Gammaproteobacteria 1236|Gammaproteobacteria M penicillin-binding protein 1A mrcA GO:0000270,GO:0003674,GO:0003824,GO:0004180,GO:0004185,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006022,GO:0006023,GO:0006024,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0008238,GO:0008360,GO:0008658,GO:0008955,GO:0009002,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016021,GO:0016740,GO:0016757,GO:0016758,GO:0016787,GO:0017171,GO:0019538,GO:0022603,GO:0022604,GO:0030203,GO:0031224,GO:0031226,GO:0031406,GO:0033218,GO:0033293,GO:0034645,GO:0036094,GO:0042221,GO:0042546,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044425,GO:0044459,GO:0044464,GO:0046677,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051128,GO:0065007,GO:0065008,GO:0070008,GO:0070011,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:0097159,GO:0140096,GO:1901135,GO:1901137,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901681 2.4.1.129,3.4.16.4 ko:K05366 ko00550,ko01100,ko01501,map00550,map01100,map01501 - - - ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 - PCB_OB,Transgly,Transpeptidase k59_96377_1 158500.BV97_00549 1.48e-114 332.0 COG0152@1|root,COG0152@2|Bacteria,1MUR9@1224|Proteobacteria,2TR8D@28211|Alphaproteobacteria,2K0D0@204457|Sphingomonadales 204457|Sphingomonadales F Belongs to the SAICAR synthetase family purC - 6.3.2.6 ko:K01923 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04591 RC00064,RC00162 ko00000,ko00001,ko00002,ko01000 - - - SAICAR_synt k59_1674708_3 1120705.FG95_03255 2.8e-18 87.0 COG4422@1|root,COG4422@2|Bacteria,1MXQI@1224|Proteobacteria,2TVMB@28211|Alphaproteobacteria,2K6EE@204457|Sphingomonadales 204457|Sphingomonadales S Protein of unknown function (DUF5131) - - - - - - - - - - - - DUF5131 k59_208284_1 1265313.HRUBRA_00669 1.09e-114 333.0 COG0307@1|root,COG0307@2|Bacteria,1MUMB@1224|Proteobacteria,1RMSY@1236|Gammaproteobacteria,1J4T6@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H riboflavin synthase, alpha ribE - 2.5.1.9 ko:K00793 ko00740,ko01100,ko01110,map00740,map01100,map01110 M00125 R00066 RC00958,RC00960 ko00000,ko00001,ko00002,ko01000 - - - Lum_binding k59_208284_2 247634.GPB2148_2415 5.79e-12 64.7 COG0108@1|root,COG0108@2|Bacteria,1MU8P@1224|Proteobacteria,1RQ49@1236|Gammaproteobacteria 1236|Gammaproteobacteria H Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate ribB - 3.5.4.25,4.1.99.12 ko:K14652 ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110 M00125,M00840 R00425,R07281 RC00293,RC01792,RC01815,RC02504 ko00000,ko00001,ko00002,ko01000 - - - DHBP_synthase,GTP_cyclohydro2 k59_1168864_1 1163617.SCD_n02687 1.85e-32 117.0 COG0219@1|root,COG0219@2|Bacteria,1RCY4@1224|Proteobacteria,2VR5W@28216|Betaproteobacteria 28216|Betaproteobacteria J Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide trmL - 2.1.1.207 ko:K03216 - - - - ko00000,ko01000,ko03016 - - - SpoU_methylase k59_1168864_2 977880.RALTA_A0280 1.89e-38 139.0 COG0240@1|root,COG0240@2|Bacteria,1MUU3@1224|Proteobacteria,2VJ91@28216|Betaproteobacteria,1JZX1@119060|Burkholderiaceae 28216|Betaproteobacteria I Glycerol-3-phosphate dehydrogenase gpsA - 1.1.1.94 ko:K00057 ko00564,ko01110,map00564,map01110 - R00842,R00844 RC00029 ko00000,ko00001,ko01000 - - - NAD_Gly3P_dh_C,NAD_Gly3P_dh_N k59_40687_1 1089553.Tph_c13360 6.14e-46 173.0 COG0072@1|root,COG0073@1|root,COG0072@2|Bacteria,COG0073@2|Bacteria,1TP98@1239|Firmicutes,248BJ@186801|Clostridia,42F4K@68295|Thermoanaerobacterales 186801|Clostridia J phenylalanyl-tRNA synthetase (beta subunit) pheT GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 6.1.1.20 ko:K01890 ko00970,map00970 M00359,M00360 R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - B3_4,B5,FDX-ACB,tRNA-synt_2d,tRNA_bind k59_40687_2 443144.GM21_2224 7.59e-38 129.0 COG0776@1|root,COG0776@2|Bacteria,1RH5Z@1224|Proteobacteria,42TK0@68525|delta/epsilon subdivisions,2WQ5D@28221|Deltaproteobacteria,43VBY@69541|Desulfuromonadales 28221|Deltaproteobacteria K This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control himA - - ko:K04764 - - - - ko00000,ko03032,ko03036,ko03400 - - - Bac_DNA_binding k59_40687_3 338963.Pcar_1425 2.16e-07 50.4 COG0789@1|root,COG0789@2|Bacteria,1RGYB@1224|Proteobacteria,42V1F@68525|delta/epsilon subdivisions,2WR79@28221|Deltaproteobacteria,43SR6@69541|Desulfuromonadales 28221|Deltaproteobacteria K helix_turn_helix, mercury resistance - - - - - - - - - - - - MerR_1 k59_605513_1 338966.Ppro_0784 4.9e-51 182.0 COG0475@1|root,COG0490@1|root,COG1226@1|root,COG0475@2|Bacteria,COG0490@2|Bacteria,COG1226@2|Bacteria,1MV34@1224|Proteobacteria,42MEM@68525|delta/epsilon subdivisions,2WK23@28221|Deltaproteobacteria,43T1F@69541|Desulfuromonadales 28221|Deltaproteobacteria P Sodium/hydrogen exchanger family - - - ko:K03455,ko:K11747 - - - - ko00000,ko02000 2.A.37,2.A.37.1.2 - - Na_H_Exchanger,TrkA_C,TrkA_N k59_1733021_1 1049564.TevJSym_ad00780 1.51e-76 246.0 COG0187@1|root,COG0187@2|Bacteria,1MVH1@1224|Proteobacteria,1RMCI@1236|Gammaproteobacteria,1J4HN@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule parE GO:0000819,GO:0003674,GO:0003824,GO:0003916,GO:0003918,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006265,GO:0006276,GO:0006725,GO:0006807,GO:0006996,GO:0007049,GO:0007059,GO:0007062,GO:0008094,GO:0008150,GO:0008152,GO:0009295,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017111,GO:0022402,GO:0030541,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051276,GO:0061505,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0098813,GO:0140097,GO:1901360 - ko:K02622 - - - - ko00000,ko01000,ko02048,ko03032,ko03036 - - - DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim k59_431446_1 272630.MexAM1_META1p2412 9.17e-25 108.0 COG2931@1|root,COG3210@1|root,COG2931@2|Bacteria,COG3210@2|Bacteria,1MU7T@1224|Proteobacteria,2TRVY@28211|Alphaproteobacteria,1JS5X@119045|Methylobacteriaceae 28211|Alphaproteobacteria QU COG2931 RTX toxins and related Ca2 -binding proteins - - - - - - - - - - - - HemolysinCabind k59_1225837_2 555793.WSK_1128 1.23e-95 287.0 COG0042@1|root,COG0042@2|Bacteria,1MV5V@1224|Proteobacteria,2TRC8@28211|Alphaproteobacteria,2K0QH@204457|Sphingomonadales 204457|Sphingomonadales J Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines - - - ko:K05540 - - - - ko00000,ko01000,ko03016 - - - Dus k59_1058004_1 330214.NIDE0303 8.62e-97 297.0 COG0265@1|root,COG0265@2|Bacteria,3J0X9@40117|Nitrospirae 2|Bacteria M Evidence 2a Function of homologous gene experimentally demonstrated in an other organism htrA GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005575,GO:0005623,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0016787,GO:0017171,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043170,GO:0044238,GO:0044464,GO:0070011,GO:0071704,GO:0140096,GO:1901564 3.4.21.107 ko:K04771 ko01503,ko02020,map01503,map02020 M00728 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 - - - PDZ,PDZ_2,Trypsin_2 k59_996274_1 1229909.NSED_09465 4.97e-111 327.0 COG0517@1|root,arCOG00600@2157|Archaea,41TAT@651137|Thaumarchaeota 651137|Thaumarchaeota S CBS domain - - - - - - - - - - - - CBS k59_381306_1 1049564.TevJSym_bb00150 4.97e-05 45.8 COG3166@1|root,COG3166@2|Bacteria,1RF1S@1224|Proteobacteria,1S3S0@1236|Gammaproteobacteria,1J61K@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria NU COG3166 Tfp pilus assembly protein PilN pilN - - ko:K02663 - - - - ko00000,ko02035,ko02044 - - - PilN k59_381306_2 519989.ECTPHS_06502 2.8e-41 147.0 COG4972@1|root,COG4972@2|Bacteria,1MX8P@1224|Proteobacteria,1RN8S@1236|Gammaproteobacteria,1WXGR@135613|Chromatiales 135613|Chromatiales NU TIGRFAM type IV pilus assembly protein PilM - - - ko:K02662 - - - - ko00000,ko02035,ko02044 - - - PilM_2 k59_41598_1 1461693.ATO10_00375 1.38e-14 75.1 COG1905@1|root,COG3743@1|root,COG1905@2|Bacteria,COG3743@2|Bacteria,1MWS2@1224|Proteobacteria,2TSEJ@28211|Alphaproteobacteria 28211|Alphaproteobacteria C COG1905 NADH ubiquinone oxidoreductase 24 kD subunit nuoE - 1.6.5.3,1.6.99.3 ko:K00334,ko:K03943 ko00190,ko01100,ko04714,ko04723,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map04714,map04723,map04932,map05010,map05012,map05016 M00143,M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1,3.D.1.6 - - 2Fe-2S_thioredx k59_1675866_1 1479238.JQMZ01000001_gene198 3.96e-55 181.0 COG3000@1|root,COG3000@2|Bacteria,1R48K@1224|Proteobacteria,2U4WF@28211|Alphaproteobacteria,43YS7@69657|Hyphomonadaceae 28211|Alphaproteobacteria I Fatty acid hydroxylase superfamily - - - - - - - - - - - - FA_hydroxylase k59_1279272_1 751945.Theos_1679 4.29e-07 52.4 COG1430@1|root,COG1430@2|Bacteria,1WJRZ@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus S Uncharacterized ACR, COG1430 - - - ko:K09005 - - - - ko00000 - - - DUF192 k59_1279272_2 323261.Noc_1074 1.81e-12 63.2 arCOG11477@1|root,32TJG@2|Bacteria,1MYXX@1224|Proteobacteria 1224|Proteobacteria S Protein of unknown function (DUF4242) - - - - - - - - - - - - DUF4242 k59_432403_2 519989.ECTPHS_06512 1.03e-33 124.0 COG1418@1|root,COG1418@2|Bacteria,1RH6M@1224|Proteobacteria,1S81F@1236|Gammaproteobacteria,1X2NE@135613|Chromatiales 135613|Chromatiales S mRNA catabolic process - - - - - - - - - - - - - k59_97319_1 1187851.A33M_0527 2.6e-07 51.2 COG3829@1|root,COG3829@2|Bacteria,1RH32@1224|Proteobacteria,2U79H@28211|Alphaproteobacteria 28211|Alphaproteobacteria KT COG2202 FOG PAS PAC domain - - - - - - - - - - - - PAS,PAS_3,PAS_9 k59_606564_1 199310.c4006 1.91e-109 323.0 COG1077@1|root,COG1077@2|Bacteria,1MUMW@1224|Proteobacteria,1RN82@1236|Gammaproteobacteria,3XNDS@561|Escherichia 1236|Gammaproteobacteria D Involved in formation of the rod shape of the cell. May act as a negative regulator of FtsI mreB GO:0000003,GO:0000910,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005856,GO:0005886,GO:0007049,GO:0008150,GO:0008360,GO:0009987,GO:0016020,GO:0019954,GO:0022402,GO:0022414,GO:0022603,GO:0022604,GO:0031224,GO:0031226,GO:0032505,GO:0042802,GO:0043093,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0048519,GO:0048523,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0051301,GO:0051302,GO:0051782,GO:0051983,GO:0065007,GO:0065008,GO:0071944 - ko:K03569 - - - - ko00000,ko02048,ko03036,ko04812 1.A.33.1,9.B.157.1 - - MreB_Mbl k59_1110757_1 795666.MW7_1375 1.01e-41 153.0 COG1538@1|root,COG1538@2|Bacteria,1MUHM@1224|Proteobacteria,2VKX1@28216|Betaproteobacteria,1K0AC@119060|Burkholderiaceae 28216|Betaproteobacteria MU Outer membrane efflux protein - - - - - - - - - - - - OEP k59_1279300_1 1121935.AQXX01000135_gene3735 1.26e-67 211.0 COG0229@1|root,COG0229@2|Bacteria,1RGWC@1224|Proteobacteria,1S5WI@1236|Gammaproteobacteria,1XPF5@135619|Oceanospirillales 135619|Oceanospirillales O methionine sulfoxide reductase - - 1.8.4.12 ko:K07305 - - - - ko00000,ko01000 - - - SelR k59_1510898_1 511062.GU3_04770 1.53e-61 202.0 COG0196@1|root,COG0196@2|Bacteria,1MV9I@1224|Proteobacteria,1RN44@1236|Gammaproteobacteria,1Y3RC@135624|Aeromonadales 135624|Aeromonadales H Belongs to the ribF family ribF - 2.7.1.26,2.7.7.2 ko:K11753 ko00740,ko01100,ko01110,map00740,map01100,map01110 M00125 R00161,R00549 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - FAD_syn,Flavokinase k59_1169858_1 700598.Niako_2950 1.95e-31 130.0 COG0457@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria,4NFW7@976|Bacteroidetes,1IR3J@117747|Sphingobacteriia 976|Bacteroidetes K Tetratricopeptide repeat - - - - - - - - - - - - Guanylate_cyc,HTH_18,TPR_16,TPR_2,TPR_8 k59_770634_1 1144305.PMI02_05444 2.31e-118 359.0 COG3590@1|root,COG3590@2|Bacteria,1MVNQ@1224|Proteobacteria,2TRU4@28211|Alphaproteobacteria,2K02W@204457|Sphingomonadales 204457|Sphingomonadales O peptidase M13 - - - ko:K07386 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M13,Peptidase_M13_N k59_324825_1 1121877.JQKF01000013_gene274 5.82e-79 254.0 COG1154@1|root,COG1154@2|Bacteria,2GMFA@201174|Actinobacteria,4CMS4@84992|Acidimicrobiia 84992|Acidimicrobiia H Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) dxs - 2.2.1.7 ko:K01662 ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130 M00096 R05636 RC00032 ko00000,ko00001,ko00002,ko01000 - - - DXP_synthase_N,Transket_pyr,Transketolase_C k59_543338_1 1041142.ATTP01000021_gene102 2.7e-48 160.0 COG1846@1|root,COG1846@2|Bacteria,1N7G0@1224|Proteobacteria,2UA2S@28211|Alphaproteobacteria,4BETA@82115|Rhizobiaceae 28211|Alphaproteobacteria K Transcriptional regulator - - - - - - - - - - - - MarR,MarR_2 k59_543338_2 349966.DJ58_2494 3.23e-10 60.8 COG2764@1|root,COG2764@2|Bacteria,1N0S4@1224|Proteobacteria,1S93U@1236|Gammaproteobacteria 1236|Gammaproteobacteria S PFAM Glyoxalase bleomycin resistance protein dioxygenase phnB - - ko:K04750 - - - - ko00000 - - - 3-dmu-9_3-mt,Glyoxalase k59_719722_1 1288494.EBAPG3_4300 3.98e-81 243.0 COG0440@1|root,COG0440@2|Bacteria,1RAGN@1224|Proteobacteria,2VH1H@28216|Betaproteobacteria,3730Y@32003|Nitrosomonadales 28216|Betaproteobacteria E TIGRFAM Acetolactate synthase, small subunit ilvH GO:0003674,GO:0003824,GO:0003984,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005948,GO:0006082,GO:0006520,GO:0006549,GO:0006573,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009097,GO:0009099,GO:0009987,GO:0016053,GO:0016740,GO:0016744,GO:0019752,GO:0032991,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494,GO:1990234 2.2.1.6 ko:K01653 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - ACT_5,ALS_ss_C k59_719722_2 261292.Nit79A3_0785 3.48e-60 200.0 COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,2VJ55@28216|Betaproteobacteria,372AD@32003|Nitrosomonadales 28216|Betaproteobacteria H TIGRFAM Acetolactate synthase, large subunit, biosynthetic ilvI - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_97347_1 391615.ABSJ01000039_gene1883 1.04e-147 431.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria 1236|Gammaproteobacteria T COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains - - - - - - - - - - - - HTH_8,Response_reg,Sigma54_activat k59_1279325_1 1246474.ANBE01000006_gene650 1.58e-47 175.0 COG2936@1|root,COG2936@2|Bacteria,2GK8B@201174|Actinobacteria 201174|Actinobacteria IQ Peptidase S15 - - - ko:K06978 - - - - ko00000 - - - PepX_C,Peptidase_S15 k59_1279325_2 521719.ATXQ01000003_gene2093 1.49e-151 435.0 COG0709@1|root,COG0709@2|Bacteria,1MWFG@1224|Proteobacteria,1RQ5Q@1236|Gammaproteobacteria,1YEPZ@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria F Synthesizes selenophosphate from selenide and ATP selD GO:0000287,GO:0001887,GO:0003674,GO:0003824,GO:0004756,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006520,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009451,GO:0009987,GO:0010467,GO:0016053,GO:0016070,GO:0016259,GO:0016260,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016781,GO:0019752,GO:0034470,GO:0034641,GO:0034660,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046872,GO:0070329,GO:0071704,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.9.3 ko:K01008 ko00450,ko01100,map00450,map01100 - R03595 RC00002,RC02878 ko00000,ko00001,ko01000,ko03016 - - iPC815.YPO2164,iSFV_1184.SFV_1453,iSF_1195.SF1459,iSFxv_1172.SFxv_1645,iS_1188.S1574 AIRS,AIRS_C k59_151748_1 13690.CP98_03203 3.74e-114 335.0 COG0583@1|root,COG0583@2|Bacteria,1NTH7@1224|Proteobacteria,2UNNZ@28211|Alphaproteobacteria,2K3E7@204457|Sphingomonadales 204457|Sphingomonadales K Bacterial regulatory helix-turn-helix protein, lysR family - - - - - - - - - - - - HTH_1,LysR_substrate k59_1110782_1 1117314.PCIT_22579 1.01e-10 67.8 COG5000@1|root,COG5000@2|Bacteria,1MWKZ@1224|Proteobacteria,1RQ8B@1236|Gammaproteobacteria,2Q03D@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria T COG5000 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation - - - - - - - - - - - - HATPase_c k59_381368_1 1430440.MGMSRv2_3623 5.81e-28 108.0 COG0455@1|root,COG0455@2|Bacteria,1R8IW@1224|Proteobacteria,2TWWA@28211|Alphaproteobacteria,2JQPP@204441|Rhodospirillales 204441|Rhodospirillales D Belongs to the ParA family - - - ko:K04562 - - - - ko00000,ko02035 - - - AAA_31,CbiA k59_381368_2 1122137.AQXF01000003_gene2186 6.01e-33 123.0 COG1419@1|root,COG1419@2|Bacteria,1MUQW@1224|Proteobacteria,2U06N@28211|Alphaproteobacteria 28211|Alphaproteobacteria N COG1419 Flagellar GTP-binding protein flhF - - ko:K02404 - - - - ko00000,ko02035 - - - SRP54 k59_1785909_1 1211115.ALIQ01000056_gene2757 1.18e-107 320.0 COG1173@1|root,COG1173@2|Bacteria,1MUG0@1224|Proteobacteria,2TT4V@28211|Alphaproteobacteria 28211|Alphaproteobacteria EP COG1173 ABC-type dipeptide oligopeptide nickel transport systems permease components - - - ko:K02034 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1,OppC_N k59_543361_1 1279019.ARQK01000060_gene2268 8.16e-69 219.0 COG0668@1|root,COG0668@2|Bacteria,1QU7U@1224|Proteobacteria,1T1Q9@1236|Gammaproteobacteria,1WZXW@135613|Chromatiales 135613|Chromatiales M Mechanosensitive ion channel - - - - - - - - - - - - MS_channel k59_432450_1 436308.Nmar_0389 8.3e-52 166.0 arCOG02709@1|root,arCOG02709@2157|Archaea 2157|Archaea S Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - 4.4.1.5 ko:K01759 ko00620,map00620 - R02530 RC00004,RC00740 ko00000,ko00001,ko01000 - - - Glyoxalase k59_940928_1 272560.BPSL2815 1.21e-63 206.0 COG0324@1|root,COG0324@2|Bacteria,1MUB2@1224|Proteobacteria,2VHEP@28216|Betaproteobacteria,1K1TT@119060|Burkholderiaceae 28216|Betaproteobacteria J Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) miaA - 2.5.1.75 ko:K00791 ko00908,ko01100,ko01110,map00908,map01100,map01110 - R01122 RC02820 ko00000,ko00001,ko01000,ko01006,ko03016 - - - IPPT k59_1621380_1 1121374.KB891585_gene2401 9.41e-60 207.0 COG0308@1|root,COG0308@2|Bacteria,1MUCI@1224|Proteobacteria,1RMA7@1236|Gammaproteobacteria 1236|Gammaproteobacteria E aminopeptidase N pepN GO:0003674,GO:0003824,GO:0004177,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006508,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008235,GO:0008237,GO:0008238,GO:0008270,GO:0009056,GO:0009987,GO:0016020,GO:0016787,GO:0019538,GO:0033218,GO:0034641,GO:0042277,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0043171,GO:0043603,GO:0044237,GO:0044238,GO:0044248,GO:0044424,GO:0044464,GO:0046872,GO:0046914,GO:0070006,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901565,GO:1901575 3.4.11.2 ko:K01256 ko00480,ko01100,map00480,map01100 - R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 - - iECIAI1_1343.ECIAI1_0973,iECO103_1326.ECO103_0977,iECP_1309.ECP_0944,iECSE_1348.ECSE_0993,iECW_1372.ECW_m1042,iEKO11_1354.EKO11_2898,iWFL_1372.ECW_m1042 DUF3458,DUF3458_C,Peptidase_M1 k59_1058077_1 96561.Dole_1860 3.13e-101 306.0 COG1960@1|root,COG1960@2|Bacteria,1R6R2@1224|Proteobacteria,42NTR@68525|delta/epsilon subdivisions,2WKRA@28221|Deltaproteobacteria,2MIWC@213118|Desulfobacterales 28221|Deltaproteobacteria C Acyl-CoA dehydrogenase type 2 domain - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_1733995_1 221288.JH992901_gene714 7.69e-13 73.6 COG2267@1|root,COG2267@2|Bacteria,1G21H@1117|Cyanobacteria,1JHNW@1189|Stigonemataceae 1117|Cyanobacteria I Serine aminopeptidase, S33 - - 3.8.1.5 ko:K01563 ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120 - R05284,R05367,R05368,R05369,R05370,R07669,R07670 RC01317,RC01340,RC01341,RC02013 ko00000,ko00001,ko01000 - - - Abhydrolase_1,Abhydrolase_6 k59_1110814_1 243233.MCA0020 3.66e-28 112.0 COG1076@1|root,COG1076@2|Bacteria,1N270@1224|Proteobacteria,1RP0P@1236|Gammaproteobacteria,1XEK0@135618|Methylococcales 135618|Methylococcales O Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host djlA - - ko:K05801 - - - - ko00000,ko03110 - - - DnaJ,TerB k59_1225913_2 497321.C664_11007 1.49e-49 159.0 COG0776@1|root,COG0776@2|Bacteria,1MZ7M@1224|Proteobacteria,2VSPN@28216|Betaproteobacteria,2KWNF@206389|Rhodocyclales 206389|Rhodocyclales K This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control ihfB - - ko:K05788 - - - - ko00000,ko03032,ko03036,ko03400 - - - Bac_DNA_binding k59_543409_1 525368.HMPREF0591_5471 1.74e-40 159.0 COG2114@1|root,COG3899@1|root,COG2114@2|Bacteria,COG3899@2|Bacteria,2GJRI@201174|Actinobacteria,2364D@1762|Mycobacteriaceae 201174|Actinobacteria T PFAM Adenylate and Guanylate cyclase catalytic domain - - - - - - - - - - - - AAA_16,Guanylate_cyc,zinc_ribbon_2 k59_658613_1 192875.XP_004345745.1 3.99e-23 99.8 COG5285@1|root,KOG3290@2759|Eukaryota,38EX9@33154|Opisthokonta 33154|Opisthokonta I phytanoyl-CoA dioxygenase activity - - 1.14.11.18 ko:K00477 ko04146,map04146 - - - ko00000,ko00001,ko01000 - - - PhyH k59_151795_1 1121015.N789_01235 3.67e-87 282.0 COG0567@1|root,COG0567@2|Bacteria,1MVBF@1224|Proteobacteria,1RN8K@1236|Gammaproteobacteria,1X4NM@135614|Xanthomonadales 135614|Xanthomonadales C E1 component of the oxoglutarate dehydrogenase complex which catalyzes the formation of succinyl-CoA from 2-oxoglutarate sucA - 1.2.4.2 ko:K00164 ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00032 R00621,R01933,R01940,R03316,R08549 RC00004,RC00027,RC00627,RC02743,RC02833,RC02883 br01601,ko00000,ko00001,ko00002,ko01000 - - - 2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr k59_1785933_1 1122137.AQXF01000002_gene53 1.06e-242 673.0 COG0008@1|root,COG0008@2|Bacteria,1MUCR@1224|Proteobacteria,2TRCI@28211|Alphaproteobacteria 28211|Alphaproteobacteria J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) gltX1 - 6.1.1.17 ko:K01885 ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120 M00121,M00359,M00360 R05578 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016 - - - tRNA-synt_1c k59_1785933_2 1122137.AQXF01000002_gene52 1.7e-66 217.0 COG0171@1|root,COG0388@1|root,COG0171@2|Bacteria,COG0388@2|Bacteria,1MU9U@1224|Proteobacteria,2TRAU@28211|Alphaproteobacteria 28211|Alphaproteobacteria H Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source nadE GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008795,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016874,GO:0016879,GO:0016880,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.1.5,6.3.5.1 ko:K01916,ko:K01950 ko00760,ko01100,map00760,map01100 M00115 R00189,R00257 RC00010,RC00100 ko00000,ko00001,ko00002,ko01000 - - - CN_hydrolase,NAD_synthase k59_41677_1 1415778.JQMM01000001_gene1021 7.48e-132 395.0 COG0768@1|root,COG0768@2|Bacteria,1MV8C@1224|Proteobacteria,1RN9H@1236|Gammaproteobacteria,1J4EU@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Catalyzes cross-linking of the peptidoglycan cell wall mrdA GO:0000270,GO:0003674,GO:0003824,GO:0004180,GO:0004185,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006022,GO:0006023,GO:0006024,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0008238,GO:0008360,GO:0008658,GO:0009002,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016021,GO:0016043,GO:0016787,GO:0017171,GO:0019538,GO:0022603,GO:0022604,GO:0030203,GO:0031224,GO:0031226,GO:0031406,GO:0033218,GO:0033293,GO:0034645,GO:0036094,GO:0042221,GO:0042493,GO:0042546,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044425,GO:0044459,GO:0044464,GO:0045229,GO:0046677,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051128,GO:0065007,GO:0065008,GO:0070008,GO:0070011,GO:0070589,GO:0071554,GO:0071555,GO:0071704,GO:0071840,GO:0071944,GO:0071972,GO:0097159,GO:0140096,GO:1901135,GO:1901137,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901681 3.4.16.4 ko:K05515 ko00550,ko01501,map00550,map01501 - - - ko00000,ko00001,ko01000,ko01011 - - iEcE24377_1341.EcE24377A_0661,iPC815.YPO2604 PBP_dimer,Transpeptidase k59_97399_1 1449065.JMLL01000010_gene1533 1.58e-87 269.0 COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,2TQQ7@28211|Alphaproteobacteria,43HJY@69277|Phyllobacteriaceae 28211|Alphaproteobacteria I Belongs to the thiolase family phbA GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N k59_1058125_1 1278073.MYSTI_00579 5.76e-70 221.0 COG1125@1|root,COG1125@2|Bacteria,1QTUC@1224|Proteobacteria,42MXW@68525|delta/epsilon subdivisions,2WK94@28221|Deltaproteobacteria 28221|Deltaproteobacteria E PFAM ABC transporter - - - ko:K05847 ko02010,map02010 M00209 - - ko00000,ko00001,ko00002,ko02000 3.A.1.12 - - ABC_tran,CBS k59_1058125_2 1278073.MYSTI_00580 2.36e-142 422.0 COG1174@1|root,COG1732@1|root,COG1174@2|Bacteria,COG1732@2|Bacteria,1MXA1@1224|Proteobacteria,42UI3@68525|delta/epsilon subdivisions,2WQ1V@28221|Deltaproteobacteria,2YVFQ@29|Myxococcales 28221|Deltaproteobacteria P Substrate binding domain of ABC-type glycine betaine transport system - - - ko:K05845,ko:K05846 ko02010,map02010 M00209 - - ko00000,ko00001,ko00002,ko02000 3.A.1.12 - - BPD_transp_1,OpuAC k59_1398116_1 438753.AZC_0992 6.16e-89 285.0 COG1884@1|root,COG2185@1|root,COG1884@2|Bacteria,COG2185@2|Bacteria,1MUXX@1224|Proteobacteria,2TQYC@28211|Alphaproteobacteria,3F14A@335928|Xanthobacteraceae 28211|Alphaproteobacteria I B12 binding domain mutB - 5.4.99.63 ko:K14447 ko00630,ko01120,ko01200,map00630,map01120,map01200 M00373 R09292 RC02835 ko00000,ko00001,ko00002,ko01000 - - - B12-binding,MM_CoA_mutase k59_1785946_1 882378.RBRH_02514 3.76e-65 216.0 COG0119@1|root,COG0119@2|Bacteria,1MUNQ@1224|Proteobacteria,2VI4G@28216|Betaproteobacteria,1K2XH@119060|Burkholderiaceae 28216|Betaproteobacteria E Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) leuA - 2.3.3.13 ko:K01649 ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230 M00432 R01213 RC00004,RC00470,RC02754 br01601,ko00000,ko00001,ko00002,ko01000 - - - HMGL-like,LeuA_dimer k59_889876_2 1122612.AUBA01000003_gene1560 5.61e-16 76.6 COG1651@1|root,COG1651@2|Bacteria,1RBWK@1224|Proteobacteria,2U6HJ@28211|Alphaproteobacteria,2K3W7@204457|Sphingomonadales 204457|Sphingomonadales M Protein-disulfide isomerase - - - - - - - - - - - - Thioredoxin_4 k59_215960_1 566466.NOR53_1352 1.12e-54 184.0 COG3268@1|root,COG3268@2|Bacteria,1MVI3@1224|Proteobacteria,1RSCK@1236|Gammaproteobacteria,1J995@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Saccharopine dehydrogenase NADP binding domain lys - - - - - - - - - - - Sacchrp_dh_NADP k59_1117683_1 1479239.JQMU01000001_gene1967 1.73e-54 182.0 2C5U9@1|root,2Z9NJ@2|Bacteria,1NEK8@1224|Proteobacteria,2U4EQ@28211|Alphaproteobacteria,2K10J@204457|Sphingomonadales 204457|Sphingomonadales S Bacterial protein of unknown function (Gcw_chp) - - - - - - - - - - - - Gcw_chp k59_1456518_1 292.DM42_7146 1.35e-44 164.0 COG0642@1|root,COG2202@1|root,COG2202@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,2VJI1@28216|Betaproteobacteria,1JZSA@119060|Burkholderiaceae 28216|Betaproteobacteria T catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR - - - - - - - - - - - - HATPase_c,HisKA,PAS_3,PAS_4,PAS_9,Response_reg k59_1064811_1 1187851.A33M_1030 5.06e-30 118.0 COG0566@1|root,COG0566@2|Bacteria,1MWCM@1224|Proteobacteria,2TUG7@28211|Alphaproteobacteria,3FD3G@34008|Rhodovulum 28211|Alphaproteobacteria J RNA 2'-O ribose methyltransferase substrate binding rlmB - 2.1.1.185 ko:K03218 - - - - ko00000,ko01000,ko03009 - - - SpoU_methylase,SpoU_sub_bind k59_836616_2 981369.JQMJ01000004_gene4275 5.15e-26 103.0 COG1438@1|root,COG1438@2|Bacteria,2GKA5@201174|Actinobacteria,2NHS5@228398|Streptacidiphilus 201174|Actinobacteria K Arginine repressor, DNA binding domain argR GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0006355,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032991,GO:0032993,GO:0043565,GO:0044212,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2001141 - ko:K03402 - - - - ko00000,ko03000 - - - Arg_repressor,Arg_repressor_C k59_389769_1 561175.KB894093_gene4400 6.78e-30 114.0 COG0377@1|root,COG0377@2|Bacteria,2GJP5@201174|Actinobacteria,4EHDU@85012|Streptosporangiales 201174|Actinobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoB2 - 1.6.5.3 ko:K00331 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q6 k59_389769_2 50960.LS81_05275 2.77e-09 63.2 COG0852@1|root,COG0852@2|Bacteria,1MX4B@1224|Proteobacteria,42NAR@68525|delta/epsilon subdivisions,2YN6R@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain nuoC - 1.6.5.3 ko:K00332 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_30kDa k59_389769_3 794903.OPIT5_14170 1.23e-10 62.4 COG0649@1|root,COG0649@2|Bacteria,46SA0@74201|Verrucomicrobia,3K7QV@414999|Opitutae 414999|Opitutae C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient - - 1.6.5.3 ko:K00333 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_49kDa k59_898118_1 1229909.NSED_03915 3.48e-63 205.0 arCOG08742@1|root,arCOG08742@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_1004479_1 1038860.AXAP01000062_gene2400 1.97e-33 130.0 COG1476@1|root,COG1476@2|Bacteria,1QYQN@1224|Proteobacteria,2TXW2@28211|Alphaproteobacteria 28211|Alphaproteobacteria K Helix-turn-helix XRE-family like proteins - - - - - - - - - - - - HTH_3 k59_105352_1 1484460.JSWG01000009_gene343 4.33e-120 352.0 COG0626@1|root,COG0626@2|Bacteria,4NF0Q@976|Bacteroidetes,1HXPE@117743|Flavobacteriia 976|Bacteroidetes E cystathionine metC - 2.5.1.48,4.4.1.1,4.4.1.8 ko:K01739,ko:K01758,ko:K01760 ko00260,ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00260,map00270,map00450,map00920,map01100,map01110,map01130,map01230 M00017,M00338 R00782,R00999,R01001,R01286,R01288,R02408,R02508,R03217,R03260,R04770,R04930,R04941,R04944,R04945,R04946,R09366 RC00020,RC00056,RC00069,RC00348,RC00382,RC00420,RC00488,RC00710,RC01209,RC01210,RC01245,RC02303,RC02848,RC02866 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Cys_Met_Meta_PP k59_1793985_1 1122137.AQXF01000002_gene361 5.83e-86 270.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2TQS3@28211|Alphaproteobacteria 28211|Alphaproteobacteria T Diguanylate cyclase MA20_18100 - 3.1.4.52 ko:K13245 ko04112,map04112 - R08991 RC00296 ko00000,ko00001,ko01000 - - - 7TMR-DISMED2,7TMR-DISM_7TM,EAL,GGDEF,PAS_3 k59_1065761_1 1216976.AX27061_5531 1.76e-71 233.0 COG0326@1|root,COG0326@2|Bacteria,1MUUE@1224|Proteobacteria,2VHHJ@28216|Betaproteobacteria,3T2E8@506|Alcaligenaceae 28216|Betaproteobacteria O Molecular chaperone. Has ATPase activity htpG - - ko:K04079 ko04141,ko04151,ko04217,ko04612,ko04621,ko04626,ko04657,ko04659,ko04914,ko04915,ko05200,ko05215,ko05418,map04141,map04151,map04217,map04612,map04621,map04626,map04657,map04659,map04914,map04915,map05200,map05215,map05418 - - - ko00000,ko00001,ko01009,ko03029,ko03051,ko03110,ko04131,ko04147 - - - HATPase_c,HATPase_c_3,HSP90 k59_1629267_1 1117314.PCIT_19464 1.51e-59 211.0 COG1629@1|root,COG1629@2|Bacteria,1MV8W@1224|Proteobacteria,1RQEQ@1236|Gammaproteobacteria,2Q0I6@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria P COG1629 Outer membrane receptor proteins, mostly Fe transport - - - - - - - - - - - - Plug,TonB_dep_Rec k59_105359_1 395961.Cyan7425_2999 4.82e-32 129.0 COG2217@1|root,COG2217@2|Bacteria,1G2R5@1117|Cyanobacteria,3KH5Y@43988|Cyanothece 1117|Cyanobacteria P ATPase, P-type (transporting), HAD superfamily, subfamily IC - - 3.6.3.4 ko:K01533 - - R00086 RC00002 ko00000,ko01000 3.A.3.5 - - E1-E2_ATPase,Hydrolase k59_1065764_1 1128421.JAGA01000002_gene1317 3.1e-10 66.2 COG2203@1|root,COG3605@1|root,COG3920@1|root,COG2203@2|Bacteria,COG3605@2|Bacteria,COG3920@2|Bacteria 2|Bacteria T Histidine kinase - - 4.2.1.75,4.6.1.1 ko:K01719,ko:K01768,ko:K02584 ko00230,ko00860,ko01100,ko01110,ko01120,ko02020,ko02025,ko04113,ko04213,map00230,map00860,map01100,map01110,map01120,map02020,map02025,map04113,map04213 M00121,M00695 R00089,R00434,R03165 RC00295,RC01861 ko00000,ko00001,ko00002,ko01000,ko03000 - - - ANTAR,GAF,GAF_2,GGDEF,HATPase_c,HATPase_c_2,HisKA_2,PAS_4 k59_1065770_1 1122138.AQUZ01000002_gene2132 3.7e-28 118.0 COG1404@1|root,COG1404@2|Bacteria,2GK3D@201174|Actinobacteria,4DSSQ@85009|Propionibacteriales 201174|Actinobacteria O PA domain - - - - - - - - - - - - Inhibitor_I9,PA,Peptidase_S8,fn3_5 k59_1457543_1 1453501.JELR01000001_gene2391 1.38e-52 186.0 COG1629@1|root,COG1629@2|Bacteria,1MX4K@1224|Proteobacteria,1RP6B@1236|Gammaproteobacteria,464ZU@72275|Alteromonadaceae 1236|Gammaproteobacteria P COG1629 Outer membrane receptor proteins, mostly Fe transport - - - - - - - - - - - - Plug,TonB_dep_Rec k59_217007_1 1191523.MROS_1885 3.11e-72 228.0 COG0020@1|root,COG0020@2|Bacteria 2|Bacteria I transferase activity, transferring alkyl or aryl (other than methyl) groups uppS GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006066,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0071704,GO:1901576,GO:1901615,GO:1901617 2.5.1.31 ko:K00806 ko00900,ko01110,map00900,map01110 - R06447 RC00279,RC02839 ko00000,ko00001,ko01000,ko01006 - - - Prenyltransf k59_217007_2 329726.AM1_0563 1.19e-21 94.0 COG0743@1|root,COG0743@2|Bacteria,1G2CU@1117|Cyanobacteria 1117|Cyanobacteria I Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) dxr GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006721,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016114,GO:0016491,GO:0016614,GO:0016616,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0030145,GO:0030604,GO:0032787,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046490,GO:0046872,GO:0046914,GO:0048037,GO:0050661,GO:0050662,GO:0051483,GO:0051484,GO:0055114,GO:0070402,GO:0071704,GO:0090407,GO:0097159,GO:1901135,GO:1901265,GO:1901363,GO:1901576 1.1.1.267 ko:K00099 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05688 RC01452 ko00000,ko00001,ko00002,ko01000 - - - DXPR_C,DXP_redisom_C,DXP_reductoisom k59_1794010_1 756067.MicvaDRAFT_3414 1.38e-24 95.5 COG2329@1|root,COG2329@2|Bacteria,1G7DQ@1117|Cyanobacteria,1HCG0@1150|Oscillatoriales 1117|Cyanobacteria S Antibiotic biosynthesis monooxygenase - - - - - - - - - - - - ABM k59_1065774_1 715226.ABI_23780 1.35e-18 92.4 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2TZ3Y@28211|Alphaproteobacteria,2KJX0@204458|Caulobacterales 204458|Caulobacterales T Double sensory domain of two-component sensor kinase - - - - - - - - - - - - EAL,GGDEF,HAMP,dCache_3 k59_948908_1 436308.Nmar_0325 6.24e-90 268.0 COG0099@1|root,arCOG01722@2157|Archaea,41SIW@651137|Thaumarchaeota 651137|Thaumarchaeota J Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits rps13 - - ko:K02952 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S13 k59_1684537_1 391624.OIHEL45_03720 2.73e-07 53.1 COG1309@1|root,COG1309@2|Bacteria,1ND64@1224|Proteobacteria,2TTVA@28211|Alphaproteobacteria 28211|Alphaproteobacteria K transcriptional regulator rutR GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:2000112,GO:2000113,GO:2001141 - ko:K09017 - - - - ko00000,ko03000 - - - TetR_C_3,TetR_N k59_1629279_2 1380394.JADL01000001_gene2036 7.25e-65 211.0 COG0438@1|root,COG0438@2|Bacteria,1MVKK@1224|Proteobacteria,2TUFG@28211|Alphaproteobacteria,2JQVA@204441|Rhodospirillales 204441|Rhodospirillales M Glycosyl transferases group 1 - - - - - - - - - - - - Glyco_transf_4,Glycos_transf_1 k59_217017_1 1453501.JELR01000002_gene638 3.32e-59 197.0 2C6D0@1|root,31F07@2|Bacteria,1RHBN@1224|Proteobacteria,1S7HH@1236|Gammaproteobacteria,467YC@72275|Alteromonadaceae 1236|Gammaproteobacteria S Domain of unknown function (DUF4340) - - - - - - - - - - - - DUF4340 k59_1576496_1 316407.85676715 6.8e-104 313.0 COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,1RMBS@1236|Gammaproteobacteria 1236|Gammaproteobacteria NU Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB gspE - - ko:K02454 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - T2SSE k59_1177415_1 158500.BV97_02579 4.09e-63 202.0 COG0472@1|root,COG0472@2|Bacteria,1MUTK@1224|Proteobacteria,2TRUG@28211|Alphaproteobacteria,2K18Y@204457|Sphingomonadales 204457|Sphingomonadales M First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan mraY - 2.7.8.13 ko:K01000 ko00550,ko01100,ko01502,map00550,map01100,map01502 - R05629,R05630 RC00002,RC02753 ko00000,ko00001,ko01000,ko01011 9.B.146 - - Glycos_transf_4,MraY_sig1 k59_1177415_2 158500.BV97_02580 1.1e-20 91.7 COG0770@1|root,COG0770@2|Bacteria,1QTSF@1224|Proteobacteria,2TR0Q@28211|Alphaproteobacteria,2K1N2@204457|Sphingomonadales 204457|Sphingomonadales M Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein murF - 6.3.2.10 ko:K01929 ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502 - R04573,R04617 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_49482_1 667632.KB890164_gene2197 1.45e-67 218.0 COG0077@1|root,COG1605@1|root,COG0077@2|Bacteria,COG1605@2|Bacteria,1MU60@1224|Proteobacteria,2VJEV@28216|Betaproteobacteria,1JZU8@119060|Burkholderiaceae 28216|Betaproteobacteria E chorismate mutase pheA - 4.2.1.51,4.2.1.91,5.4.99.5 ko:K01713,ko:K14170 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00024,M00025 R00691,R01373,R01715 RC00360,RC03116 ko00000,ko00001,ko00002,ko01000 - - - ACT,CM_2,PDT k59_1684548_1 1379701.JPJC01000250_gene1533 2.55e-38 143.0 COG2303@1|root,COG2303@2|Bacteria,1MU3F@1224|Proteobacteria,2TT3C@28211|Alphaproteobacteria,2K0QC@204457|Sphingomonadales 204457|Sphingomonadales E Oxidoreductase - - 1.1.5.9 ko:K19813 ko00030,ko01100,ko01110,ko01130,map00030,map01100,map01110,map01130 - R00305 RC00066 ko00000,ko00001,ko01000 - - - FAD_binding_2,GMC_oxred_C,GMC_oxred_N,NAD_binding_8 k59_614841_1 1117315.AHCA01000026_gene4155 1.26e-84 268.0 COG1070@1|root,COG1070@2|Bacteria,1MUHF@1224|Proteobacteria,1RRPS@1236|Gammaproteobacteria 1236|Gammaproteobacteria G FGGY family of carbohydrate kinases, N-terminal domain - - - - - - - - - - - - FGGY_N k59_440695_1 316407.85675598 1.24e-194 546.0 COG0148@1|root,COG0148@2|Bacteria,1MU1N@1224|Proteobacteria,1RNQA@1236|Gammaproteobacteria,3XNNK@561|Escherichia 1236|Gammaproteobacteria F Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis eno GO:0000015,GO:0000287,GO:0003674,GO:0003824,GO:0004634,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005856,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009986,GO:0009987,GO:0016052,GO:0016053,GO:0016310,GO:0016829,GO:0016835,GO:0016836,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0032991,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042802,GO:0042866,GO:0043167,GO:0043169,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046872,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1902494 4.2.1.11 ko:K01689 ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066 M00001,M00002,M00003,M00346,M00394 R00658 RC00349 ko00000,ko00001,ko00002,ko01000,ko03019,ko04147 - - iPC815.YPO3376 Enolase_C,Enolase_N k59_275005_1 216432.CA2559_12648 7.99e-35 137.0 COG1352@1|root,COG2201@1|root,COG3290@1|root,COG4251@1|root,COG1352@2|Bacteria,COG2201@2|Bacteria,COG3290@2|Bacteria,COG4251@2|Bacteria,4NE3J@976|Bacteroidetes,1HWYQ@117743|Flavobacteriia 976|Bacteroidetes T COG2201 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain - - 2.1.1.80,3.1.1.61 ko:K13924 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko02022,ko02035 - - - CheB_methylest,CheR,CheR_N,HATPase_c,HisKA,PAS,PAS_10,PAS_3,PAS_4,PAS_9 k59_1457562_2 1298593.TOL_1418 1.05e-47 158.0 COG2346@1|root,COG2346@2|Bacteria,1RH21@1224|Proteobacteria,1S4I5@1236|Gammaproteobacteria,1XKX5@135619|Oceanospirillales 135619|Oceanospirillales S Bacterial-like globin - - - ko:K06886 - - - - ko00000 - - - Bac_globin k59_1457562_3 1247963.JPHU01000008_gene2900 1.25e-23 102.0 COG0477@1|root,COG2814@2|Bacteria,1QYNP@1224|Proteobacteria,2U1VX@28211|Alphaproteobacteria 28211|Alphaproteobacteria EGP Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 k59_1406619_1 522306.CAP2UW1_2837 6.78e-76 232.0 COG2128@1|root,COG2128@2|Bacteria,1MUDM@1224|Proteobacteria,2VIMU@28216|Betaproteobacteria,1KQN1@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria O Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - 4.1.1.44 ko:K01607 ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220 - R03470 RC00938 ko00000,ko00001,ko01000 - - - CMD k59_778288_1 443255.SCLAV_p1233 4.15e-40 154.0 COG1028@1|root,COG3321@1|root,COG1028@2|Bacteria,COG3321@2|Bacteria,2H477@201174|Actinobacteria 201174|Actinobacteria Q polyketide synthase - - - ko:K13611,ko:K15314 ko01059,ko01130,map01059,map01130 M00824,M00825 R11435 - ko00000,ko00001,ko00002,ko01004,ko01008 - - - Acyl_transf_1,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,PS-DH,ketoacyl-synt k59_898176_1 1122201.AUAZ01000007_gene3617 5.4e-73 234.0 COG0168@1|root,COG0168@2|Bacteria,1MUIJ@1224|Proteobacteria,1RMN6@1236|Gammaproteobacteria,464EN@72275|Alteromonadaceae 1236|Gammaproteobacteria P Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA trkH GO:0003674,GO:0005215,GO:0005216,GO:0005261,GO:0005267,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015267,GO:0015318,GO:0015672,GO:0016020,GO:0016021,GO:0022803,GO:0022838,GO:0022857,GO:0022890,GO:0030001,GO:0030955,GO:0031224,GO:0031226,GO:0031420,GO:0034220,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0044425,GO:0044459,GO:0044464,GO:0046872,GO:0046873,GO:0046983,GO:0051179,GO:0051234,GO:0055085,GO:0071804,GO:0071805,GO:0071944,GO:0098655,GO:0098660,GO:0098662 - ko:K03498 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - iPC815.YPO3762,iSFV_1184.SFV_3651 TrkH k59_1406624_1 1229909.NSED_04395 2.47e-24 92.8 arCOG11516@1|root,arCOG11516@2157|Archaea,41T9Y@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1406624_2 436308.Nmar_0792 2.24e-48 154.0 arCOG08711@1|root,arCOG08711@2157|Archaea,41T4I@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_159814_1 1121413.JMKT01000015_gene313 6.13e-32 128.0 COG0642@1|root,COG2202@1|root,COG2203@1|root,COG2202@2|Bacteria,COG2203@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,43ED4@68525|delta/epsilon subdivisions,2X81C@28221|Deltaproteobacteria 28221|Deltaproteobacteria T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA,PAS_4,PAS_9,Response_reg k59_496166_2 519989.ECTPHS_06812 2.2e-42 150.0 COG2805@1|root,COG2805@2|Bacteria,1MU3J@1224|Proteobacteria,1RN8G@1236|Gammaproteobacteria,1WWZV@135613|Chromatiales 135613|Chromatiales NU PFAM Type II secretion system protein E - - - - - - - - - - - - T2SSE k59_1576519_1 1144305.PMI02_02109 1.04e-83 261.0 COG4638@1|root,COG4638@2|Bacteria,1R4IX@1224|Proteobacteria,2U511@28211|Alphaproteobacteria,2K30Q@204457|Sphingomonadales 204457|Sphingomonadales P PFAM Rieske 2Fe-2S domain - - - - - - - - - - - - Rieske,Ring_hydroxyl_A k59_898185_1 998674.ATTE01000001_gene4408 5.28e-22 97.4 COG0006@1|root,COG0006@2|Bacteria,1MUZS@1224|Proteobacteria,1RN0W@1236|Gammaproteobacteria,45ZRX@72273|Thiotrichales 1236|Gammaproteobacteria E Belongs to the peptidase M24B family - - - - - - - - - - - - Peptidase_M24 k59_898185_2 326297.Sama_0669 5.98e-86 270.0 COG0405@1|root,COG0405@2|Bacteria,1MUV6@1224|Proteobacteria,1RMIT@1236|Gammaproteobacteria,2QA5R@267890|Shewanellaceae 1236|Gammaproteobacteria M gamma-glutamyltransferase ggt_2 - 2.3.2.2,3.4.19.13 ko:K00681 ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100 - R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935 RC00064,RC00090,RC00096 ko00000,ko00001,ko01000,ko01002 - - - G_glu_transpept k59_275021_1 211165.AJLN01000049_gene6034 5.31e-64 209.0 COG1893@1|root,COG1893@2|Bacteria,1G2H9@1117|Cyanobacteria,1JJM7@1189|Stigonemataceae 1117|Cyanobacteria H Ketopantoate reductase PanE/ApbA C terminal - - 1.1.1.169 ko:K00077 ko00770,ko01100,ko01110,map00770,map01100,map01110 M00119 R02472 RC00726 ko00000,ko00001,ko00002,ko01000 - - - ApbA,ApbA_C k59_440742_1 1444309.JAQG01000157_gene3277 0.000238 45.1 COG3829@1|root,COG3829@2|Bacteria,1TP0E@1239|Firmicutes,4HADT@91061|Bacilli,26TKA@186822|Paenibacillaceae 91061|Bacilli KT Transcriptional regulator - - - - - - - - - - - - HTH_8,PAS,PAS_4,PAS_9,Sigma54_activat k59_105418_1 1001585.MDS_4769 3.68e-71 222.0 COG4122@1|root,COG4122@2|Bacteria,1RB4I@1224|Proteobacteria,1S0WP@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Methyltransferase domain - - - - - - - - - - - - Methyltransf_24 k59_159829_2 1122137.AQXF01000002_gene393 1.21e-27 111.0 COG0144@1|root,COG0144@2|Bacteria,1MV2Q@1224|Proteobacteria,2TS6U@28211|Alphaproteobacteria 28211|Alphaproteobacteria J Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB NOP family sun1 - 2.1.1.176 ko:K03500 - - - - ko00000,ko01000,ko03009 - - - Methyltr_RsmB-F k59_667092_1 1096930.L284_19665 8.05e-61 211.0 COG4774@1|root,COG4774@2|Bacteria,1NMCN@1224|Proteobacteria,2TYET@28211|Alphaproteobacteria,2KEM3@204457|Sphingomonadales 204457|Sphingomonadales P TonB dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_1233385_1 1144305.PMI02_00158 1.24e-13 69.7 COG1024@1|root,COG1024@2|Bacteria,1Q51H@1224|Proteobacteria,2TUPH@28211|Alphaproteobacteria,2K2FJ@204457|Sphingomonadales 204457|Sphingomonadales I Enoyl-CoA hydratase isomerase - - 4.2.1.17 ko:K01692 ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212 M00032,M00087 R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093 RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 - - - ECH_1 k59_1233385_2 13690.CP98_03904 3.21e-148 429.0 COG1960@1|root,COG1960@2|Bacteria,1MVJC@1224|Proteobacteria,2TTRD@28211|Alphaproteobacteria,2K02R@204457|Sphingomonadales 204457|Sphingomonadales I PFAM Acyl-CoA dehydrogenase, C-terminal domain, Acyl-CoA dehydrogenase, middle domain, Acyl-CoA dehydrogenase, N-terminal domain - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_948993_1 1283300.ATXB01000001_gene1620 1.13e-55 184.0 COG1131@1|root,COG1131@2|Bacteria,1MUW7@1224|Proteobacteria,1RMC5@1236|Gammaproteobacteria,1XEVT@135618|Methylococcales 135618|Methylococcales V AAA domain, putative AbiEii toxin, Type IV TA system - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_948996_2 1108045.GORHZ_241_00120 1.61e-37 140.0 COG0446@1|root,COG0446@2|Bacteria,2GJKT@201174|Actinobacteria,4GD49@85026|Gordoniaceae 201174|Actinobacteria S Reductase C-terminal - - - - - - - - - - - - Pyr_redox_2,Reductase_C k59_667119_1 1123057.P872_14010 1.34e-69 232.0 COG1251@1|root,COG1251@2|Bacteria,4NE44@976|Bacteroidetes,47M7X@768503|Cytophagia 976|Bacteroidetes C Nitrite and sulphite reductase 4Fe-4S - - 1.7.1.15 ko:K00362 ko00910,ko01120,map00910,map01120 M00530 R00787 RC00176 ko00000,ko00001,ko00002,ko01000 - - - Fer2_BFD,NIR_SIR,NIR_SIR_ferr,Pyr_redox_2 k59_1794077_1 1288494.EBAPG3_10740 4.67e-91 283.0 COG0173@1|root,COG0173@2|Bacteria,1MUXB@1224|Proteobacteria,2VHKQ@28216|Betaproteobacteria,371U3@32003|Nitrosomonadales 28216|Betaproteobacteria J Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) aspS - 6.1.1.12 ko:K01876 ko00970,map00970 M00359,M00360 R05577 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - GAD,tRNA-synt_2,tRNA_anti-codon k59_837780_1 1267211.KI669560_gene608 4.83e-29 107.0 COG3631@1|root,COG3631@2|Bacteria,4NP12@976|Bacteroidetes 976|Bacteroidetes S SnoaL-like polyketide cyclase - - - - - - - - - - - - SnoaL,SnoaL_2 k59_49534_1 414684.RC1_3961 9.12e-78 238.0 COG0066@1|root,COG0066@2|Bacteria,1MVXB@1224|Proteobacteria,2TRRS@28211|Alphaproteobacteria,2JPTP@204441|Rhodospirillales 204441|Rhodospirillales E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate leuD - 4.2.1.33,4.2.1.35 ko:K01704 ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230 M00432,M00535 R03896,R03898,R03968,R04001,R10170 RC00976,RC00977,RC01041,RC01046,RC03072 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase_C k59_105452_1 626887.J057_23620 3.52e-69 233.0 COG0013@1|root,COG0013@2|Bacteria,1MU9A@1224|Proteobacteria,1RMWZ@1236|Gammaproteobacteria,465GZ@72275|Alteromonadaceae 1236|Gammaproteobacteria J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain alaS GO:0001130,GO:0001131,GO:0001141,GO:0001217,GO:0002161,GO:0002196,GO:0003674,GO:0003700,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006355,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006450,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009451,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016070,GO:0016597,GO:0016787,GO:0016788,GO:0016874,GO:0016875,GO:0019219,GO:0019222,GO:0019538,GO:0019752,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0042802,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045934,GO:0046483,GO:0046872,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0052689,GO:0060255,GO:0065007,GO:0065008,GO:0071704,GO:0080090,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:0140110,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 6.1.1.7 ko:K01872 ko00970,map00970 M00359,M00360 R03038 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iECABU_c1320.ECABU_c29670,iECED1_1282.ECED1_3146,iEcHS_1320.EcHS_A2833,iJN746.PP_4474 DHHA1,tRNA-synt_2c,tRNA_SAD k59_1004612_1 702113.PP1Y_AT5672 1.2e-116 347.0 COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2TQR1@28211|Alphaproteobacteria,2JZVD@204457|Sphingomonadales 204457|Sphingomonadales C belongs to the aldehyde dehydrogenase family - - - ko:K00138 ko00010,ko00620,ko01100,ko01110,ko01120,map00010,map00620,map01100,map01110,map01120 - R00711 RC00047 ko00000,ko00001,ko01000 - - - Aldedh k59_159863_1 1177594.MIC448_550016 9.78e-35 136.0 COG0438@1|root,COG1413@1|root,COG0438@2|Bacteria,COG1413@2|Bacteria,2HMNV@201174|Actinobacteria,4FKQ8@85023|Microbacteriaceae 201174|Actinobacteria CM Glycosyl transferases group 1 - - 2.4.1.250 ko:K15521 - - - - ko00000,ko01000 - - - Glyco_transf_4,Glycos_transf_1,HEAT_2 k59_217102_1 42254.XP_004619248.1 5e-39 148.0 COG0175@1|root,KOG2644@2759|Eukaryota,38HX0@33154|Opisthokonta,3BBJ2@33208|Metazoa,3CRI8@33213|Bilateria,480QA@7711|Chordata,48V0M@7742|Vertebrata,3J2H6@40674|Mammalia 33208|Metazoa EH FAD biosynthetic process FLAD1 GO:0003674,GO:0003824,GO:0003919,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006725,GO:0006732,GO:0006747,GO:0006753,GO:0006766,GO:0006767,GO:0006771,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016779,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0042726,GO:0042727,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046443,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0055114,GO:0070566,GO:0071704,GO:0071944,GO:0072387,GO:0072388,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.1.228,2.7.7.2 ko:K00953,ko:K15429 ko00740,ko01100,ko01110,map00740,map01100,map01110 M00125 R00161,R00597 RC00002,RC00003,RC00334 ko00000,ko00001,ko00002,ko01000,ko03016 - - - MoCF_biosynth,PAPS_reduct k59_1684614_2 232721.Ajs_3784 1.88e-87 268.0 COG2801@1|root,COG2801@2|Bacteria,1MVN5@1224|Proteobacteria,2VKH2@28216|Betaproteobacteria,4ACGF@80864|Comamonadaceae 28216|Betaproteobacteria L Integrase, catalytic region - - - ko:K07497 - - - - ko00000 - - - HTH_21,HTH_Tnp_1,rve,rve_3 k59_728192_1 478741.JAFS01000002_gene639 3.08e-05 53.1 COG0823@1|root,COG0823@2|Bacteria,46SSK@74201|Verrucomicrobia,37GCW@326457|unclassified Verrucomicrobia 74201|Verrucomicrobia U WD40-like Beta Propeller Repeat tolB - - ko:K03641 - - - - ko00000,ko02000 2.C.1.2 - - PD40 k59_449939_1 1122137.AQXF01000001_gene2515 1.94e-70 221.0 COG2091@1|root,COG2091@2|Bacteria 2|Bacteria H lysine biosynthetic process via aminoadipic acid - - 2.7.8.7 ko:K00997,ko:K06133 ko00770,map00770 - R01625 RC00002 ko00000,ko00001,ko01000 - - - ACPS k59_561008_1 247633.GP2143_10047 3.09e-55 187.0 COG0477@1|root,COG2814@2|Bacteria,1MVSC@1224|Proteobacteria,1S029@1236|Gammaproteobacteria,1J786@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria EGP COG0477 Permeases of the major facilitator superfamily - - - - - - - - - - - - MFS_1 k59_561008_2 981369.JQMJ01000003_gene8023 3.74e-52 176.0 2AMYE@1|root,31CVH@2|Bacteria,2GNQN@201174|Actinobacteria,2NMCT@228398|Streptacidiphilus 201174|Actinobacteria - - - - - - - - - - - - - - - k59_1693958_1 1205753.A989_16318 4.79e-35 135.0 COG0654@1|root,COG0654@2|Bacteria,1R7UC@1224|Proteobacteria,1S1B9@1236|Gammaproteobacteria,1X3BJ@135614|Xanthomonadales 135614|Xanthomonadales H Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid kmo GO:0003674,GO:0003824,GO:0004497,GO:0008150,GO:0008152,GO:0009058,GO:0016491,GO:0019748,GO:0044550,GO:0055114 1.14.13.9 ko:K00486 ko00380,ko01100,map00380,map01100 M00038 R01960 RC00046 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_3 k59_1693958_2 1124780.ANNU01000010_gene3648 7.19e-16 77.4 COG3844@1|root,COG3844@2|Bacteria,4NECS@976|Bacteroidetes,47KPP@768503|Cytophagia 976|Bacteroidetes E Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively kynU - 3.7.1.3 ko:K01556 ko00380,ko01100,map00380,map01100 M00038 R00987,R02668,R03936 RC00284,RC00415 ko00000,ko00001,ko00002,ko01000 - - - Aminotran_5 k59_1750728_1 1415779.JOMH01000001_gene2603 2.06e-51 169.0 2BWTE@1|root,32VHK@2|Bacteria,1N4V1@1224|Proteobacteria,1TAMN@1236|Gammaproteobacteria,1XBAP@135614|Xanthomonadales 135614|Xanthomonadales S Protein of unknown function (DUF2937) - - - - - - - - - - - - DUF2937 k59_1013435_1 1484460.JSWG01000009_gene451 3.42e-06 54.3 COG2356@1|root,COG2374@1|root,COG2356@2|Bacteria,COG2374@2|Bacteria,4NINJ@976|Bacteroidetes,1HZEY@117743|Flavobacteriia 976|Bacteroidetes L endonuclease I - - - - - - - - - - - - LTD k59_1803202_1 395493.BegalDRAFT_0037 1.47e-87 268.0 COG2304@1|root,COG2304@2|Bacteria,1MXQ7@1224|Proteobacteria,1RMDX@1236|Gammaproteobacteria,4604T@72273|Thiotrichales 72273|Thiotrichales S von Willebrand factor, type A - - - ko:K07114 - - - - ko00000,ko02000 1.A.13.2.2,1.A.13.2.3 - - VWA,VWA_2 k59_449952_1 1096930.L284_00095 2.09e-140 405.0 COG0448@1|root,COG0448@2|Bacteria,1MVTC@1224|Proteobacteria,2TR6D@28211|Alphaproteobacteria,2K0QP@204457|Sphingomonadales 204457|Sphingomonadales H Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans glgC - 2.7.7.27 ko:K00975 ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026 M00565 R00948 RC00002 ko00000,ko00001,ko00002,ko01000 - - - NTP_transferase k59_1128032_1 1232410.KI421425_gene1553 4.67e-54 190.0 COG4932@1|root,COG4932@2|Bacteria,1QZFW@1224|Proteobacteria 1224|Proteobacteria M domain protein - - - - - - - - - - - - DUF11,SdrD_B k59_1353200_1 443255.SCLAV_5309 1.3e-35 133.0 COG1028@1|root,COG1028@2|Bacteria,2ICY8@201174|Actinobacteria 201174|Actinobacteria IQ KR domain - - - - - - - - - - - - adh_short_C2 k59_1297160_1 1415778.JQMM01000001_gene1134 5.88e-49 166.0 2C5F4@1|root,31I7F@2|Bacteria,1RHUH@1224|Proteobacteria,1S7M2@1236|Gammaproteobacteria,1J6PV@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_1297161_1 436308.Nmar_1038 6.41e-73 223.0 COG1392@1|root,arCOG02640@2157|Archaea,41SGI@651137|Thaumarchaeota 651137|Thaumarchaeota P Protein of unknown function DUF47 - - - ko:K07220 - - - - ko00000 - - - PhoU_div k59_1297161_2 1229909.NSED_06115 2.98e-23 92.8 COG1676@1|root,arCOG01701@2157|Archaea,41SHW@651137|Thaumarchaeota 651137|Thaumarchaeota L tRNA intron endonuclease, N-terminal domain - - 4.6.1.16 ko:K01170 - - - - ko00000,ko01000,ko03016 - - - tRNA_int_endo,tRNA_int_endo_N k59_787459_1 1123393.KB891316_gene1534 3.41e-26 108.0 COG3829@1|root,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria,2VHQS@28216|Betaproteobacteria,1KSCG@119069|Hydrogenophilales 119069|Hydrogenophilales KT Sigma-54 interaction domain - - - - - - - - - - - - HTH_8,PAS_4,Sigma54_activat k59_958148_1 436308.Nmar_0546 1.79e-38 140.0 COG0436@1|root,COG1605@1|root,arCOG01130@2157|Archaea,arCOG02098@2157|Archaea,41SBV@651137|Thaumarchaeota 651137|Thaumarchaeota E Chorismate mutase type II - - 2.6.1.1 ko:K00812 ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230 - R00355,R00694,R00734,R00896,R02433,R02619,R05052 RC00006 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_1_2,CM_2 k59_1466847_1 1229909.NSED_01120 1.15e-161 471.0 COG1241@1|root,arCOG00439@2157|Archaea,41SA7@651137|Thaumarchaeota 651137|Thaumarchaeota L Belongs to the MCM family - - - ko:K10726 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - MCM,MCM_N,MCM_OB k59_1242678_2 1121920.AUAU01000010_gene48 4.29e-43 152.0 COG0132@1|root,COG0132@2|Bacteria 2|Bacteria H Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring bioD GO:0003674,GO:0003824,GO:0004141,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016882,GO:0017144,GO:0018130,GO:0019752,GO:0032787,GO:0034641,GO:0042364,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.1.21,6.3.2.3,6.3.3.3 ko:K00857,ko:K01920,ko:K01935 ko00240,ko00270,ko00480,ko00780,ko00983,ko01100,map00240,map00270,map00480,map00780,map00983,map01100 M00118,M00123,M00573,M00577 R00497,R01567,R02099,R03182,R08233,R10994 RC00002,RC00017,RC00096,RC00141,RC00868 ko00000,ko00001,ko00002,ko01000 - - - AAA_26,TK k59_787485_1 1279017.AQYJ01000028_gene2183 5.34e-94 288.0 COG0811@1|root,COG0811@2|Bacteria,1MX5J@1224|Proteobacteria,1RMSA@1236|Gammaproteobacteria,4641Y@72275|Alteromonadaceae 1236|Gammaproteobacteria U MotA TolQ ExbB proton channel - - - ko:K03561 - - - - ko00000,ko02000 1.A.30.2.1 - - MotA_ExbB k59_787485_2 1415778.JQMM01000001_gene720 2.98e-15 72.4 COG0811@1|root,COG0811@2|Bacteria,1MX60@1224|Proteobacteria,1RRX1@1236|Gammaproteobacteria,1J5SH@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria U COG0811 Biopolymer transport proteins exbB - - ko:K03561 - - - - ko00000,ko02000 1.A.30.2.1 - - MotA_ExbB k59_1013492_1 1087448.Eab7_1293 2.06e-60 206.0 COG2008@1|root,COG2008@2|Bacteria,1TPZI@1239|Firmicutes,4HAM3@91061|Bacilli 91061|Bacilli E Threonine aldolase - - - - - - - - - - - - Beta_elim_lyase k59_1242692_2 644076.SCH4B_2868 8.61e-10 63.9 COG0697@1|root,COG0697@2|Bacteria,1MXPW@1224|Proteobacteria,2U1CD@28211|Alphaproteobacteria,4NBDU@97050|Ruegeria 28211|Alphaproteobacteria EG integral membrane protein - - - ko:K15270 - - - - ko00000,ko02000 2.A.7.3.7 - - EamA k59_1750795_1 469383.Cwoe_3578 3.25e-48 171.0 COG1169@1|root,COG1169@2|Bacteria,2GKE8@201174|Actinobacteria,4CQEB@84995|Rubrobacteria 84995|Rubrobacteria HQ chorismate binding enzyme menF - 5.4.4.2 ko:K02552 ko00130,ko01053,ko01100,ko01110,ko01130,map00130,map01053,map01100,map01110,map01130 M00116 R01717 RC00588 ko00000,ko00001,ko00002,ko01000 - - - Chorismate_bind k59_1750795_2 452637.Oter_3647 1.4e-06 50.4 COG1165@1|root,COG1165@2|Bacteria,46URH@74201|Verrucomicrobia,3K7F4@414999|Opitutae 414999|Opitutae H Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) menD - 2.2.1.9 ko:K02551 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116 R08165 RC02186 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M_2,TPP_enzyme_N k59_1750813_1 401053.AciPR4_2966 1.7e-67 216.0 COG3547@1|root,COG3547@2|Bacteria,3Y5SI@57723|Acidobacteria,2JKWK@204432|Acidobacteriia 204432|Acidobacteriia L PFAM transposase IS116 IS110 IS902 family protein - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_676144_1 1211115.ALIQ01000026_gene699 2.95e-90 272.0 COG2084@1|root,COG2084@2|Bacteria,1MUGU@1224|Proteobacteria,2TT50@28211|Alphaproteobacteria,3NAG4@45404|Beijerinckiaceae 28211|Alphaproteobacteria I NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase MA20_25935 - 1.1.1.31,1.1.1.60 ko:K00020,ko:K00042 ko00280,ko00630,ko01100,map00280,map00630,map01100 - R01745,R01747,R05066 RC00099 ko00000,ko00001,ko01000 - - - NAD_binding_11,NAD_binding_2 k59_958174_1 1283299.AUKG01000002_gene5002 2.77e-34 134.0 COG1020@1|root,COG1020@2|Bacteria,2GKGU@201174|Actinobacteria,4CQYP@84995|Rubrobacteria 84995|Rubrobacteria Q Protein of unknown function (DUF1298) - - - - - - - - - - - - DUF1298,WES_acyltransf k59_1750816_1 1219035.NT2_23_00020 3.03e-76 248.0 COG3119@1|root,COG3119@2|Bacteria,1MV92@1224|Proteobacteria,2TTXG@28211|Alphaproteobacteria 28211|Alphaproteobacteria P Arylsulfatase - - 3.1.6.1 ko:K01130 ko00140,ko00600,map00140,map00600 - R03980,R04856 RC00128,RC00231 ko00000,ko00001,ko01000 - - - Sulfatase k59_1466883_1 648996.Theam_0753 4.19e-64 220.0 COG0841@1|root,COG0841@2|Bacteria,2G3UQ@200783|Aquificae 200783|Aquificae V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_1242717_1 247633.GP2143_15021 4.73e-95 287.0 COG4972@1|root,COG4972@2|Bacteria,1MX8P@1224|Proteobacteria,1RN8S@1236|Gammaproteobacteria,1J4VC@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria NU COG4972 Tfp pilus assembly protein, ATPase PilM pilM - - ko:K02662 - - - - ko00000,ko02035,ko02044 - - - PilM_2 k59_1297239_1 1122947.FR7_1422 2.32e-10 68.6 COG3852@1|root,COG3852@2|Bacteria,1TRH0@1239|Firmicutes,4H9HP@909932|Negativicutes 909932|Negativicutes T Histidine kinase - - - - - - - - - - - - - k59_1242731_1 1134474.O59_002815 1.67e-49 180.0 COG2199@1|root,COG2200@1|root,COG2204@1|root,COG2199@2|Bacteria,COG2200@2|Bacteria,COG2204@2|Bacteria,1PJCA@1224|Proteobacteria,1RS4H@1236|Gammaproteobacteria,1FGZT@10|Cellvibrio 1236|Gammaproteobacteria T Putative diguanylate phosphodiesterase - - - ko:K21025 ko02025,map02025 - - - ko00000,ko00001 - - - EAL,GGDEF,PAS,PAS_8,PAS_9,Response_reg k59_676182_1 511145.b2436 6.27e-51 168.0 COG0408@1|root,COG0408@2|Bacteria,1MWMF@1224|Proteobacteria,1RMM8@1236|Gammaproteobacteria,3XMMV@561|Escherichia 1236|Gammaproteobacteria H Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX hemF GO:0003674,GO:0003824,GO:0004109,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016491,GO:0016627,GO:0016634,GO:0018130,GO:0019438,GO:0030145,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0046872,GO:0046906,GO:0046914,GO:0046983,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 1.3.3.3 ko:K00228 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R03220 RC00884 ko00000,ko00001,ko00002,ko01000 - - iAF1260.b2436,iBWG_1329.BWG_2198,iECDH10B_1368.ECDH10B_2601,iECDH1ME8569_1439.ECDH1ME8569_2370,iETEC_1333.ETEC_2549,iEcDH1_1363.EcDH1_1225,iEcHS_1320.EcHS_A2573,iEcolC_1368.EcolC_1243,iJO1366.b2436,iJR904.b2436,iY75_1357.Y75_RS12760 Coprogen_oxidas k59_676182_2 316407.1799865 7e-136 389.0 COG0860@1|root,COG0860@2|Bacteria,1MUQK@1224|Proteobacteria,1RMQR@1236|Gammaproteobacteria,3XMRY@561|Escherichia 1236|Gammaproteobacteria M N-acetylmuramoyl-L-alanine amidase amiA amiA GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0008270,GO:0008745,GO:0016787,GO:0016810,GO:0016811,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043167,GO:0043169,GO:0044464,GO:0046872,GO:0046914,GO:0061783 3.5.1.28 ko:K01448 ko01503,map01503 M00727 R04112 RC00064,RC00141 ko00000,ko00001,ko00002,ko01000,ko01011,ko03036 - - - Amidase_3 k59_958219_1 1278971.AOGF01000012_gene2692 5.78e-08 58.9 COG1593@1|root,COG3090@1|root,COG1593@2|Bacteria,COG3090@2|Bacteria,1MU0F@1224|Proteobacteria,1RNAM@1236|Gammaproteobacteria,1Y733@135625|Pasteurellales 135625|Pasteurellales G Tripartite ATP-independent periplasmic transporter, DctM component siaT GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - - - - - - - - - - DctM,DctQ k59_958219_2 1121440.AUMA01000022_gene2037 1.27e-24 104.0 COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,42M9N@68525|delta/epsilon subdivisions,2WIZR@28221|Deltaproteobacteria 28221|Deltaproteobacteria G PFAM TRAP C4-dicarboxylate transport system permease DctM subunit - - - - - - - - - - - - DctM k59_1013569_1 1247963.JPHU01000009_gene2421 8.55e-51 171.0 COG1024@1|root,COG1024@2|Bacteria,1PJ4R@1224|Proteobacteria,2TSSU@28211|Alphaproteobacteria 28211|Alphaproteobacteria I Belongs to the enoyl-CoA hydratase isomerase family - - 4.2.1.17 ko:K01692 ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212 M00032,M00087 R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093 RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 - - - ECH_1 k59_1466918_1 391625.PPSIR1_28323 3.51e-58 197.0 COG1384@1|root,COG1384@2|Bacteria,1MV32@1224|Proteobacteria,42YMX@68525|delta/epsilon subdivisions,2WTJU@28221|Deltaproteobacteria 28221|Deltaproteobacteria J tRNA synthetases class I (K) lysS - 6.1.1.6 ko:K04566 ko00970,map00970 M00360 R03658 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_1f k59_1013571_1 870187.Thini_1120 3.95e-11 60.5 COG0359@1|root,COG0359@2|Bacteria,1RD0R@1224|Proteobacteria,1S3WS@1236|Gammaproteobacteria,460T3@72273|Thiotrichales 72273|Thiotrichales J binds to the 23S rRNA rplI - - ko:K02939 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L9_C,Ribosomal_L9_N k59_1013571_2 1049564.TevJSym_ac00860 9.64e-41 148.0 COG0305@1|root,COG0305@2|Bacteria,1MUG9@1224|Proteobacteria,1RPM2@1236|Gammaproteobacteria,1J4Z9@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins dnaB - 3.6.4.12 ko:K02314 ko03030,ko04112,map03030,map04112 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB,DnaB_C k59_1242746_1 990285.RGCCGE502_22325 1.9e-68 217.0 COG4427@1|root,COG4427@2|Bacteria,1R4EV@1224|Proteobacteria,2TRVP@28211|Alphaproteobacteria,4B83Q@82115|Rhizobiaceae 28211|Alphaproteobacteria S protein conserved in bacteria - - 3.1.1.29 ko:K01056 - - - - ko00000,ko01000,ko03012 - - - DUF2332 k59_676235_1 1121921.KB898709_gene434 8.39e-83 259.0 COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,1RNAM@1236|Gammaproteobacteria,2PMWF@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria G Tripartite ATP-independent periplasmic transporter, DctM component - - - - - - - - - - - - DctM k59_1242761_1 498211.CJA_3690 3.15e-33 132.0 COG3177@1|root,COG3177@2|Bacteria,1RJSD@1224|Proteobacteria,1S9AR@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Domain of unknown function (DUF4157) - - - - - - - - - - - - DUF4157 k59_1803360_1 247634.GPB2148_3704 1.42e-79 248.0 COG4651@1|root,COG4651@2|Bacteria,1QUQS@1224|Proteobacteria,1T21E@1236|Gammaproteobacteria 1236|Gammaproteobacteria P sodium hydrogen antiporter kefC_1 - - - - - - - - - - - Na_H_Exchanger k59_1353365_2 69328.PVLB_20115 6.04e-62 207.0 COG0129@1|root,COG0129@2|Bacteria,1MU3T@1224|Proteobacteria,1RMNA@1236|Gammaproteobacteria 1236|Gammaproteobacteria EG Belongs to the IlvD Edd family edd GO:0003674,GO:0003824,GO:0004456,GO:0005975,GO:0006082,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016052,GO:0016054,GO:0016829,GO:0016835,GO:0016836,GO:0019520,GO:0019521,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044262,GO:0044275,GO:0044281,GO:0044282,GO:0046176,GO:0046177,GO:0046395,GO:0071704,GO:0072329,GO:1901575 4.2.1.12 ko:K01690 ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200 M00008 R02036 RC00543 ko00000,ko00001,ko00002,ko01000 - - iEcolC_1368.EcolC_1781,iJN746.PP_1010,iPC815.YPO2533,iYL1228.KPN_02366 ILVD_EDD k59_676258_2 1131266.ARWQ01000011_gene123 1.58e-13 70.1 COG0018@1|root,arCOG00487@2157|Archaea,41SAI@651137|Thaumarchaeota 651137|Thaumarchaeota J Belongs to the class-I aminoacyl-tRNA synthetase family argS - 6.1.1.19 ko:K01887 ko00970,map00970 M00359,M00360 R03646 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d k59_169079_1 715451.ambt_19240 8.1e-34 117.0 COG1278@1|root,COG1278@2|Bacteria,1N6Q5@1224|Proteobacteria,1SCA7@1236|Gammaproteobacteria,46816@72275|Alteromonadaceae 1236|Gammaproteobacteria K COG1278 Cold shock proteins - - - ko:K03704 - - - - ko00000,ko03000 - - - CSD k59_450080_1 1088721.NSU_2660 1.39e-185 524.0 COG0715@1|root,COG0715@2|Bacteria,1MWDN@1224|Proteobacteria,2TS0X@28211|Alphaproteobacteria,2K4FK@204457|Sphingomonadales 204457|Sphingomonadales P NMT1-like family - - - ko:K15576 ko00910,ko02010,map00910,map02010 M00438 - - ko00000,ko00001,ko00002,ko02000 3.A.1.16.1,3.A.1.16.2 - - NMT1_2 k59_505274_1 743721.Psesu_2614 2.14e-119 362.0 COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,1RQUR@1236|Gammaproteobacteria,1X2Z8@135614|Xanthomonadales 135614|Xanthomonadales F Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen - - 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - LAGLIDADG_3,Ribonuc_red_lgC,Ribonuc_red_lgN k59_1803385_2 1121912.AUHD01000004_gene2202 8.05e-76 233.0 COG2339@1|root,COG2339@2|Bacteria,4NGUS@976|Bacteroidetes,1HY3J@117743|Flavobacteriia 976|Bacteroidetes S Protease prsW family - - - - - - - - - - - - PrsW-protease k59_676287_1 765912.Thimo_0060 5.95e-59 199.0 COG0815@1|root,COG0815@2|Bacteria,1MUBU@1224|Proteobacteria,1RM8M@1236|Gammaproteobacteria,1WWSQ@135613|Chromatiales 135613|Chromatiales M Transfers the fatty acyl group on membrane lipoproteins lnt - - ko:K03820 - - - - ko00000,ko01000 - GT2 - CN_hydrolase k59_1694134_1 1266925.JHVX01000003_gene527 1.3e-96 291.0 COG0379@1|root,COG0379@2|Bacteria,1MWQU@1224|Proteobacteria,2VH6N@28216|Betaproteobacteria,371UG@32003|Nitrosomonadales 28216|Betaproteobacteria H Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate nadA - 2.5.1.72 ko:K03517 ko00760,ko01100,map00760,map01100 M00115 R04292 RC01119 ko00000,ko00001,ko00002,ko01000 - - - NadA k59_505292_1 1042376.AFPK01000043_gene1059 4.54e-49 171.0 COG0397@1|root,COG0397@2|Bacteria,4NEIV@976|Bacteroidetes,1HXHE@117743|Flavobacteriia,406U3@61432|unclassified Flavobacteriaceae 976|Bacteroidetes S Uncharacterized ACR, YdiU/UPF0061 family - - - - - - - - - - - - UPF0061 k59_1128189_1 1297865.APJD01000014_gene982 3.8e-69 233.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2TQT0@28211|Alphaproteobacteria,3JXAF@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria V MMPL family - - - ko:K18138,ko:K18307 ko01501,ko01503,ko02024,map01501,map01503,map02024 M00644,M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000 2.A.6.2,2.A.6.2.20,2.A.6.2.32 - - ACR_tran k59_1013620_1 1453501.JELR01000001_gene3097 3.05e-100 301.0 COG0205@1|root,COG0205@2|Bacteria,1MVN3@1224|Proteobacteria,1RMVY@1236|Gammaproteobacteria,465WX@72275|Alteromonadaceae 1236|Gammaproteobacteria G Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions pfp - 2.7.1.11,2.7.1.90 ko:K21071 ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130 - R00756,R00764,R02073,R03236,R04779 RC00002,RC00017 ko00000,ko00001,ko01000 - - - PFK k59_1467013_1 62928.azo1048 2.85e-92 277.0 COG0159@1|root,COG0159@2|Bacteria,1MXJV@1224|Proteobacteria,2VI78@28216|Betaproteobacteria,2KV5S@206389|Rhodocyclales 206389|Rhodocyclales E The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate trpA - 4.2.1.20 ko:K01695 ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230 M00023 R00674,R02340,R02722 RC00209,RC00210,RC00700,RC00701,RC02868 ko00000,ko00001,ko00002,ko01000 - - - Trp_syntA k59_1467013_2 243160.BMAA1721 5.47e-45 156.0 COG0133@1|root,COG0133@2|Bacteria,1MUS8@1224|Proteobacteria,2VHV3@28216|Betaproteobacteria,1JZSI@119060|Burkholderiaceae 28216|Betaproteobacteria E The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine trpB GO:0000162,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0042802,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.2.1.20 ko:K01696 ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230 M00023 R00674,R02340,R02722 RC00209,RC00210,RC00700,RC00701,RC02868 ko00000,ko00001,ko00002,ko01000 - - - PALP k59_564487_1 1267533.KB906737_gene1806 2.33e-11 69.3 COG0489@1|root,COG3206@1|root,COG0489@2|Bacteria,COG3206@2|Bacteria,3Y2V7@57723|Acidobacteria,2JIYH@204432|Acidobacteriia 204432|Acidobacteriia D G-rich domain on putative tyrosine kinase - - - ko:K16554 ko05111,map05111 - - - ko00000,ko00001,ko02000 8.A.3.1 - - AAA_31,CbiA,GNVR,Wzz k59_564500_1 1229909.NSED_06965 1.76e-93 285.0 arCOG08777@1|root,arCOG10350@1|root,arCOG08777@2157|Archaea,arCOG10350@2157|Archaea 2157|Archaea C sister chromatid segregation - - - - - - - - - - - - - k59_508439_1 1349767.GJA_3945 2.09e-57 207.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,475DR@75682|Oxalobacteraceae 28216|Betaproteobacteria T Putative diguanylate phosphodiesterase - - - - - - - - - - - - EAL,GGDEF,MASE2,PAS_4,PAS_9 k59_790542_1 504487.JCM19302_1440 3.1e-162 468.0 COG0173@1|root,COG0173@2|Bacteria,4NECY@976|Bacteroidetes,1HX3S@117743|Flavobacteriia 976|Bacteroidetes J Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp) aspS - 6.1.1.12 ko:K01876 ko00970,map00970 M00359,M00360 R05577 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - GAD,tRNA-synt_2,tRNA_anti-codon k59_790581_1 436308.Nmar_1725 3.74e-116 340.0 COG0301@1|root,arCOG00038@2157|Archaea,41T1A@651137|Thaumarchaeota 651137|Thaumarchaeota H Thiamine biosynthesis protein (ThiI) - - - - - - - - - - - - DUF814,ThiI k59_1016909_1 1499967.BAYZ01000001_gene5910 5.77e-76 255.0 COG0525@1|root,COG0525@2|Bacteria,2NNKR@2323|unclassified Bacteria 2|Bacteria J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner valS GO:0000287,GO:0002161,GO:0003674,GO:0003824,GO:0004812,GO:0004832,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006417,GO:0006418,GO:0006438,GO:0006450,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0016070,GO:0016787,GO:0016788,GO:0016874,GO:0016875,GO:0019222,GO:0019538,GO:0019752,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0034248,GO:0034250,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045727,GO:0045903,GO:0046483,GO:0046872,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0052689,GO:0060255,GO:0061475,GO:0065007,GO:0065008,GO:0071704,GO:0080090,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:2000112 6.1.1.9 ko:K01873 ko00970,map00970 M00359,M00360 R03665 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iECH74115_1262.ECH74115_5779,iECNA114_1301.ECNA114_4481,iECO26_1355.ECO26_5428,iECSP_1301.ECSP_5359,iECs_1301.ECs5235,iG2583_1286.G2583_5088,iJN746.PP_0977,iSBO_1134.SBO_4182,iSSON_1240.SSON_4443,iYL1228.KPN_04663,iZ_1308.Z5870 Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1 k59_564647_1 1122137.AQXF01000007_gene3625 5.32e-166 476.0 COG2224@1|root,COG2224@2|Bacteria,1MWIF@1224|Proteobacteria,2TU0Q@28211|Alphaproteobacteria 28211|Alphaproteobacteria C Isocitrate lyase aceA - 4.1.3.1 ko:K01637 ko00630,ko01100,ko01110,ko01120,ko01200,map00630,map01100,map01110,map01120,map01200 M00012 R00479 RC00311,RC00313 ko00000,ko00001,ko00002,ko01000 - - - ICL k59_1016931_1 1149133.ppKF707_0217 3.89e-13 75.1 COG2304@1|root,COG3419@1|root,COG2304@2|Bacteria,COG3419@2|Bacteria,1NUAV@1224|Proteobacteria,1RPV3@1236|Gammaproteobacteria,1YFM9@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria NU Neisseria PilC beta-propeller domain pilY1 - - ko:K02674 - - - - ko00000,ko02035,ko02044 - - - Neisseria_PilC,VWA_2 k59_564663_1 153948.NAL212_1398 7.99e-95 282.0 COG0220@1|root,COG0220@2|Bacteria,1MUWJ@1224|Proteobacteria,2VJN2@28216|Betaproteobacteria,371VV@32003|Nitrosomonadales 28216|Betaproteobacteria J Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA trmB - 2.1.1.33 ko:K03439 - - - - ko00000,ko01000,ko03016 - - - Methyltransf_4 k59_564756_1 502025.Hoch_0370 7.58e-05 50.4 COG4447@1|root,COG4447@2|Bacteria,1R42J@1224|Proteobacteria,42WGC@68525|delta/epsilon subdivisions,2WRHI@28221|Deltaproteobacteria,2YVIP@29|Myxococcales 28221|Deltaproteobacteria S cellulose binding - - - - - - - - - - - - - k59_564757_1 377629.TERTU_2321 1.5e-06 50.8 COG2755@1|root,COG2755@2|Bacteria,1N3FB@1224|Proteobacteria,1RW9E@1236|Gammaproteobacteria,2PPTD@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria E GDSL-like Lipase/Acylhydrolase - - - - - - - - - - - - CBM_6,Lipase_GDSL_2 k59_1806351_1 1408422.JHYF01000002_gene2607 3.12e-13 80.1 COG0515@1|root,COG2815@1|root,COG0515@2|Bacteria,COG2815@2|Bacteria,1TP3F@1239|Firmicutes,2492G@186801|Clostridia,36DBS@31979|Clostridiaceae 186801|Clostridia KLT serine threonine protein kinase prkC - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - PASTA,Pkinase k59_456803_1 760117.JN27_07085 7.3e-35 132.0 COG2133@1|root,COG2133@2|Bacteria,1R86D@1224|Proteobacteria,2VTBE@28216|Betaproteobacteria,475Z6@75682|Oxalobacteraceae 28216|Betaproteobacteria G Glucose / Sorbosone dehydrogenase - - - - - - - - - - - - GSDH k59_456803_2 1071400.LBUCD034_0772 9.77e-25 103.0 COG0524@1|root,COG0524@2|Bacteria,1TQRC@1239|Firmicutes,4HA87@91061|Bacilli,3F3S5@33958|Lactobacillaceae 91061|Bacilli H Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway rbsK - 2.7.1.15 ko:K00852 ko00030,map00030 - R01051,R02750 RC00002,RC00017 ko00000,ko00001,ko01000 - - - PfkB,Rib_5-P_isom_A k59_1756061_1 497321.C664_17632 2.86e-77 237.0 COG0476@1|root,COG0476@2|Bacteria,1MW7H@1224|Proteobacteria,2VI1U@28216|Betaproteobacteria,2KUF5@206389|Rhodocyclales 206389|Rhodocyclales H COG0476 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 thiF - 2.7.7.80 ko:K21029 ko04122,map04122 - R07459 RC00043 ko00000,ko00001,ko01000 - - - ThiF k59_1699626_1 748247.AZKH_1671 1.21e-70 226.0 COG0845@1|root,COG0845@2|Bacteria,1PJHF@1224|Proteobacteria,2VIRN@28216|Betaproteobacteria 28216|Betaproteobacteria M TIGRFAM efflux transporter, RND family, MFP subunit - - - ko:K02005 - - - - ko00000 - - - HlyD_3 k59_1586449_1 1545915.JROG01000004_gene2193 3.26e-68 216.0 COG1028@1|root,COG1028@2|Bacteria,1R4GD@1224|Proteobacteria,2TVNF@28211|Alphaproteobacteria,2K2GT@204457|Sphingomonadales 204457|Sphingomonadales IQ COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - - - - - - - - - - - adh_short_C2 k59_4865_1 1049564.TevJSym_ai00660 1.25e-43 161.0 COG1331@1|root,COG1331@2|Bacteria,1MUUT@1224|Proteobacteria,1RSQQ@1236|Gammaproteobacteria,1J9D0@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O Protein of unknown function, DUF255 - - - ko:K06888 - - - - ko00000 - - - DsbC,GlcNAc_2-epim,Thioredox_DsbH k59_795929_2 648757.Rvan_2351 2.38e-56 181.0 COG2983@1|root,COG2983@2|Bacteria,1RHMX@1224|Proteobacteria,2U99S@28211|Alphaproteobacteria,3N6XD@45401|Hyphomicrobiaceae 28211|Alphaproteobacteria S Belongs to the UPF0260 family MA20_15575 - - ko:K09160 - - - - ko00000 - - - CxxCxxCC k59_795929_3 207954.MED92_01891 6.95e-25 96.3 COG3100@1|root,COG3100@2|Bacteria,1N83J@1224|Proteobacteria,1SCCD@1236|Gammaproteobacteria,1XKZ7@135619|Oceanospirillales 135619|Oceanospirillales S YcgL domain-containing protein - - - ko:K09902 - - - - ko00000 - - - YcgL k59_795929_4 1046724.KB889888_gene430 1.36e-19 92.4 COG0349@1|root,COG0349@2|Bacteria,1MURV@1224|Proteobacteria,1RPBP@1236|Gammaproteobacteria,464UE@72275|Alteromonadaceae 1236|Gammaproteobacteria J Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides rnd GO:0000175,GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004532,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008408,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016796,GO:0016896,GO:0033890,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0140098,GO:1901360 3.1.13.5 ko:K03684 - - - - ko00000,ko01000,ko03016 - - - DNA_pol_A_exo1,HRDC k59_118025_1 314287.GB2207_01122 1.23e-40 153.0 COG2844@1|root,COG2844@2|Bacteria,1MV54@1224|Proteobacteria,1RN5T@1236|Gammaproteobacteria,1J51H@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen glnD GO:0003674,GO:0003824,GO:0006082,GO:0006464,GO:0006520,GO:0006541,GO:0006542,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008773,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016740,GO:0016772,GO:0016779,GO:0019538,GO:0019752,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044283,GO:0046394,GO:0070569,GO:0071704,GO:0140096,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.7.59 ko:K00990 ko02020,map02020 - - - ko00000,ko00001,ko01000 - - - ACT,GlnD_UR_UTase,HD,NTP_transf_2 k59_1756102_1 1197477.IA57_05790 2.18e-131 390.0 COG0034@1|root,COG0034@2|Bacteria,4NFSM@976|Bacteroidetes,1HXZE@117743|Flavobacteriia 976|Bacteroidetes F Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine purF - 2.4.2.14 ko:K00764 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048 R01072 RC00010,RC02724,RC02752 ko00000,ko00001,ko00002,ko01000,ko01002 - - - GATase_6,GATase_7,Pribosyltran k59_1022219_1 436308.Nmar_1690 2.65e-69 221.0 COG1156@1|root,arCOG00865@2157|Archaea,41SPY@651137|Thaumarchaeota 651137|Thaumarchaeota C Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit atpB - - ko:K02118 ko00190,ko01100,map00190,map01100 M00159 - - ko00000,ko00001,ko00002 3.A.2.2,3.A.2.3 - - ATP-synt_ab,ATP-synt_ab_N k59_1022219_2 436308.Nmar_1689 1.26e-20 86.7 COG1394@1|root,arCOG04101@2157|Archaea,41T0N@651137|Thaumarchaeota 651137|Thaumarchaeota C Produces ATP from ADP in the presence of a proton gradient across the membrane atpD - - ko:K02120 ko00190,ko01100,map00190,map01100 M00159 - - ko00000,ko00001,ko00002 3.A.2.2,3.A.2.3 - - ATP-synt_D k59_174576_1 702113.PP1Y_AT2438 8e-123 358.0 COG3118@1|root,COG3118@2|Bacteria,1MV0R@1224|Proteobacteria,2TS5X@28211|Alphaproteobacteria,2K0HB@204457|Sphingomonadales 204457|Sphingomonadales O Thioredoxin - - - ko:K05838 - - - - ko00000,ko03110 - - - TPR_15,TPR_19,TPR_20,Thioredoxin k59_345505_1 1144305.PMI02_01598 5.82e-58 195.0 COG1053@1|root,COG1053@2|Bacteria,1NRI1@1224|Proteobacteria,2UPW2@28211|Alphaproteobacteria,2K8NK@204457|Sphingomonadales 204457|Sphingomonadales C FAD dependent oxidoreductase - - 1.3.99.4 ko:K05898 ko00984,ko01100,ko01120,map00984,map01100,map01120 - R09884 RC00991 ko00000,ko00001,ko01000 - - - FAD_binding_2 k59_175632_1 388739.RSK20926_15466 6.08e-35 138.0 2F01Z@1|root,33T5S@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_797333_1 264732.Moth_0402 1.12e-14 72.0 COG2050@1|root,COG2050@2|Bacteria,1VFHF@1239|Firmicutes,24QNY@186801|Clostridia,42H63@68295|Thermoanaerobacterales 186801|Clostridia Q Thioesterase superfamily - - - ko:K02614 ko00360,map00360 - R09840 RC00004,RC00014 ko00000,ko00001,ko01000 - - - 4HBT k59_6367_1 98439.AJLL01000068_gene1521 4.25e-17 85.9 COG3975@1|root,COG3975@2|Bacteria,1G0YP@1117|Cyanobacteria,1JJDG@1189|Stigonemataceae 1117|Cyanobacteria S M61 glycyl aminopeptidase - - - - - - - - - - - - PDZ_2,Peptidase_M61 k59_63080_2 1124780.ANNU01000006_gene2926 4.06e-07 51.2 COG0636@1|root,COG0636@2|Bacteria,4NURW@976|Bacteroidetes,47S5V@768503|Cytophagia 976|Bacteroidetes C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation atpE GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0044769,GO:0045259,GO:0045263,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - ko:K02110 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt_C k59_63080_3 1122991.BAIZ01000015_gene1343 4e-05 46.2 COG0356@1|root,COG0356@2|Bacteria,4NEPK@976|Bacteroidetes,2FNAB@200643|Bacteroidia 976|Bacteroidetes C it plays a direct role in the translocation of protons across the membrane atpB - - ko:K02108 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko03110 3.A.2.1 - - ATP-synt_A k59_1700784_1 485913.Krac_11123 3.56e-53 183.0 COG0260@1|root,COG0260@2|Bacteria,2G617@200795|Chloroflexi 200795|Chloroflexi E Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides pepA - 3.4.11.1 ko:K01255 ko00480,ko01100,map00480,map01100 - R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 - - - Peptidase_M17,Peptidase_M17_N k59_458088_1 983544.Lacal_1991 2.96e-46 157.0 COG0463@1|root,COG0463@2|Bacteria,4NEVT@976|Bacteroidetes,1HXT8@117743|Flavobacteriia 976|Bacteroidetes M glycosyl transferase family 2 arnC - - - - - - - - - - - Glycos_transf_2 k59_458088_2 1317122.ATO12_14215 7.05e-38 132.0 2DM6B@1|root,31WK9@2|Bacteria,4NQK1@976|Bacteroidetes,1I2ZA@117743|Flavobacteriia,2YJQA@290174|Aquimarina 976|Bacteroidetes S Protein of unknown function (DUF4199) - - - - - - - - - - - - DUF4199 k59_1475220_1 1249627.D779_1212 3.95e-60 199.0 COG0438@1|root,COG0438@2|Bacteria,1MUB7@1224|Proteobacteria,1RQYE@1236|Gammaproteobacteria,1WW8E@135613|Chromatiales 135613|Chromatiales M PFAM Glycosyl transferase, group 1 - - - - - - - - - - - - Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1 k59_1418254_1 1550073.JROH01000045_gene2962 4.1e-73 230.0 COG0192@1|root,COG0192@2|Bacteria,1MUFQ@1224|Proteobacteria,2TR4P@28211|Alphaproteobacteria,2K02E@204457|Sphingomonadales 204457|Sphingomonadales H Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme metK - 2.5.1.6 ko:K00789 ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230 M00034,M00035,M00368,M00609 R00177,R04771 RC00021,RC01211 ko00000,ko00001,ko00002,ko01000 - - - S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N k59_231868_1 313596.RB2501_03425 2.58e-27 115.0 COG1361@1|root,COG2730@1|root,COG2885@1|root,COG3209@1|root,COG1361@2|Bacteria,COG2730@2|Bacteria,COG2885@2|Bacteria,COG3209@2|Bacteria,4NG16@976|Bacteroidetes,1HY10@117743|Flavobacteriia 976|Bacteroidetes M C-terminal domain of CHU protein family - - - - - - - - - - - - CHU_C,Calx-beta,DUF11,SdrD_B k59_1475229_1 1116472.MGMO_11c00470 6.61e-21 87.8 COG0457@1|root,COG0457@2|Bacteria,1RC44@1224|Proteobacteria,1SCGV@1236|Gammaproteobacteria,1XFRD@135618|Methylococcales 135618|Methylococcales S Tetratricopeptide repeat - - - - - - - - - - - - - k59_1475229_2 1187851.A33M_1270 1.3e-17 82.8 COG3604@1|root,COG3604@2|Bacteria,1QTT3@1224|Proteobacteria,2TW04@28211|Alphaproteobacteria,3FCHI@34008|Rhodovulum 28211|Alphaproteobacteria KT Domain present in phytochromes and cGMP-specific phosphodiesterases. nifA - - ko:K02584 ko02020,map02020 - - - ko00000,ko00001,ko03000 - - - GAF,HTH_8,Sigma54_activat k59_570808_1 1229909.NSED_02430 4.71e-54 170.0 arCOG11286@1|root,arCOG11286@2157|Archaea 2157|Archaea S Nitrogen regulatory protein P-II - - - - - - - - - - - - P-II k59_570808_2 436308.Nmar_0487 7.56e-57 177.0 COG0640@1|root,arCOG01680@2157|Archaea 2157|Archaea K regulatory protein, arsR - - - ko:K03892,ko:K21903 - - - - ko00000,ko03000 - - - HTH_20,HTH_5 k59_570808_3 1459636.NTE_00057 2.19e-17 77.4 COG0394@1|root,arCOG04425@2157|Archaea,41T49@651137|Thaumarchaeota 651137|Thaumarchaeota T PFAM low molecular weight phosphotyrosine protein phosphatase - - 1.20.4.1 ko:K03741 - - - - ko00000,ko01000 - - - LMWPc k59_345537_1 287.DR97_1963 1.16e-42 155.0 COG2271@1|root,COG2271@2|Bacteria,1MWYR@1224|Proteobacteria,1RR7T@1236|Gammaproteobacteria,1YD63@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria G Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 k59_740782_1 911045.PSE_0850 8.83e-62 196.0 COG1226@1|root,COG1226@2|Bacteria,1QYC1@1224|Proteobacteria,2TXMV@28211|Alphaproteobacteria 28211|Alphaproteobacteria P COG1226 Kef-type K transport systems - - - ko:K10716 - - - - ko00000,ko02000 1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6 - - Ion_trans,Ion_trans_2 k59_740782_2 1528106.JRJE01000005_gene1259 1.9e-30 119.0 COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2TR7Q@28211|Alphaproteobacteria,2JQKF@204441|Rhodospirillales 204441|Rhodospirillales C III protein, CoA-transferase family - - 2.8.3.16 ko:K07749 - - - - ko00000,ko01000 - - - CoA_transf_3 k59_1079296_1 1323663.AROI01000016_gene419 7.24e-19 84.0 COG4795@1|root,COG4795@2|Bacteria 2|Bacteria U General secretion pathway protein gspJ - - ko:K02459 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - N_methyl,T2SSJ k59_119487_1 1117319.PSPO_09154 2.02e-45 169.0 COG1629@1|root,COG4771@2|Bacteria,1MUWN@1224|Proteobacteria,1RN1E@1236|Gammaproteobacteria,2Q0FU@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria P COG1629 Outer membrane receptor proteins, mostly Fe transport - - - - - - - - - - - - CarbopepD_reg_2,CarboxypepD_reg,Plug,TonB_dep_Rec k59_1531698_1 384765.SIAM614_05075 2.69e-23 95.9 COG0559@1|root,COG0559@2|Bacteria,1MU25@1224|Proteobacteria,2TSZP@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Belongs to the binding-protein-dependent transport system permease family - - - ko:K01997,ko:K11956 ko02010,ko02024,map02010,map02024 M00237,M00322 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4,3.A.1.4.2,3.A.1.4.6 - - BPD_transp_2 k59_1531698_2 305700.B447_06572 7.04e-56 180.0 COG0410@1|root,COG0410@2|Bacteria,1MVVC@1224|Proteobacteria,2VQT6@28216|Betaproteobacteria 28216|Betaproteobacteria E ATPases associated with a variety of cellular activities - - - ko:K01996,ko:K11958 ko02010,ko02024,map02010,map02024 M00237,M00322 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4,3.A.1.4.2,3.A.1.4.6 - - ABC_tran k59_6396_1 316407.1651503 6.36e-115 362.0 COG0506@1|root,COG3905@1|root,COG4230@1|root,COG0506@2|Bacteria,COG3905@2|Bacteria,COG4230@2|Bacteria,1MV93@1224|Proteobacteria,1RN48@1236|Gammaproteobacteria,3XMSS@561|Escherichia 1236|Gammaproteobacteria K Oxidizes proline to glutamate for use as a carbon and nitrogen source putA GO:0000166,GO:0000976,GO:0000984,GO:0000986,GO:0000987,GO:0001017,GO:0001067,GO:0001130,GO:0001131,GO:0001141,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0003824,GO:0003842,GO:0004657,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006355,GO:0006520,GO:0006536,GO:0006560,GO:0006562,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009064,GO:0009065,GO:0009889,GO:0009890,GO:0009892,GO:0009898,GO:0009987,GO:0010133,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016020,GO:0016054,GO:0016491,GO:0016645,GO:0016646,GO:0019219,GO:0019222,GO:0019752,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043436,GO:0043565,GO:0043648,GO:0044212,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044425,GO:0044459,GO:0044464,GO:0045892,GO:0045934,GO:0046395,GO:0046483,GO:0046700,GO:0048037,GO:0048519,GO:0048523,GO:0050660,GO:0050662,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0055114,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0097159,GO:0098552,GO:0098562,GO:0140110,GO:1901265,GO:1901360,GO:1901361,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2001141 1.2.1.88,1.5.5.2 ko:K13821 ko00250,ko00330,ko01100,ko01110,ko01130,map00250,map00330,map01100,map01110,map01130 - R00245,R00707,R00708,R01253,R04444,R04445,R05051 RC00080,RC00083,RC00216,RC00242,RC00255 ko00000,ko00001,ko01000,ko03000 - - iPC815.YPO1851,iSbBS512_1146.SbBS512_E2304 Aldedh,Pro_dh,Pro_dh-DNA_bdg k59_740787_1 203122.Sde_2572 2.03e-102 315.0 COG0508@1|root,COG0508@2|Bacteria,1MU7K@1224|Proteobacteria,1RNPT@1236|Gammaproteobacteria,464DV@72275|Alteromonadaceae 1236|Gammaproteobacteria C The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) aceF - 2.3.1.12 ko:K00627 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200 M00307 R00209,R02569 RC00004,RC02742,RC02857 br01601,ko00000,ko00001,ko00002,ko01000 - - - 2-oxoacid_dh,Biotin_lipoyl,E3_binding k59_63109_1 1229909.NSED_02935 8.48e-91 274.0 COG0517@1|root,arCOG00600@2157|Archaea,41TAT@651137|Thaumarchaeota 651137|Thaumarchaeota S CBS domain - - - - - - - - - - - - CBS k59_1305769_1 631362.Thi970DRAFT_01519 3.58e-26 99.4 COG0251@1|root,COG0251@2|Bacteria,1MZ3J@1224|Proteobacteria,1S5XS@1236|Gammaproteobacteria,1WY7E@135613|Chromatiales 135613|Chromatiales J PFAM Endoribonuclease L-PSP - - 3.5.99.10 ko:K09022 - - R11098,R11099 RC03275,RC03354 ko00000,ko01000 - - - Ribonuc_L-PSP k59_1305769_2 519989.ECTPHS_04239 3.03e-28 114.0 COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,1RN3H@1236|Gammaproteobacteria,1WWZ3@135613|Chromatiales 135613|Chromatiales KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance - - 2.7.6.5,3.1.7.2 ko:K01139 ko00230,map00230 - R00336,R00429 RC00002,RC00078 ko00000,ko00001,ko01000,ko03009 - - - ACT_4,HD_4,RelA_SpoT,TGS k59_797386_1 391619.PGA1_c10880 8.21e-28 113.0 COG0787@1|root,COG0787@2|Bacteria,1MV0Q@1224|Proteobacteria,2TQKD@28211|Alphaproteobacteria,34E1D@302485|Phaeobacter 28211|Alphaproteobacteria M Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids alr - 5.1.1.1 ko:K01775 ko00473,ko01100,ko01502,map00473,map01100,map01502 - R00401 RC00285 ko00000,ko00001,ko01000,ko01011 - - - Ala_racemase_C,Ala_racemase_N k59_63122_1 1207055.C100_18175 5.59e-32 120.0 COG1028@1|root,COG1028@2|Bacteria,1MU32@1224|Proteobacteria,2TUYY@28211|Alphaproteobacteria,2K9P7@204457|Sphingomonadales 204457|Sphingomonadales IQ Enoyl-(Acyl carrier protein) reductase - - 1.1.1.100 ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 k59_570820_1 1121447.JONL01000001_gene703 1.13e-29 110.0 COG0098@1|root,COG0098@2|Bacteria,1MUS4@1224|Proteobacteria,42QX0@68525|delta/epsilon subdivisions,2WNBN@28221|Deltaproteobacteria,2M8B9@213115|Desulfovibrionales 28221|Deltaproteobacteria J Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body rpsE GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02988 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S5,Ribosomal_S5_C k59_570820_2 426114.THI_3019 1.17e-14 68.2 COG1841@1|root,COG1841@2|Bacteria,1N6ZE@1224|Proteobacteria,2VVPT@28216|Betaproteobacteria,1KMNP@119065|unclassified Burkholderiales 28216|Betaproteobacteria J Ribosomal protein L30 rpmD - - ko:K02907 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L30 k59_570820_3 999423.HMPREF9161_01583 9.95e-31 115.0 COG0200@1|root,COG0200@2|Bacteria,1V3KE@1239|Firmicutes,4H4B5@909932|Negativicutes 909932|Negativicutes J binds to the 23S rRNA rplO - - ko:K02876 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L27A k59_1248953_1 1117647.M5M_17495 1.03e-82 253.0 COG1792@1|root,COG1792@2|Bacteria,1N8ZS@1224|Proteobacteria,1RMK4@1236|Gammaproteobacteria,1J4IH@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Cell shape-determining protein mreC GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0007163,GO:0008150,GO:0008360,GO:0009987,GO:0016020,GO:0016021,GO:0022603,GO:0022604,GO:0031224,GO:0031226,GO:0043621,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0065007,GO:0065008,GO:0071944,GO:0071963 - ko:K03570 - - - - ko00000,ko03036 9.B.157.1 - - MreC k59_1644780_1 1415778.JQMM01000001_gene1540 3.72e-52 186.0 COG0587@1|root,COG0587@2|Bacteria,1MUIF@1224|Proteobacteria,1RP0K@1236|Gammaproteobacteria,1J4NP@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L DNA polymerase III, alpha subunit dnaE GO:0003674,GO:0003824,GO:0003887,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032991,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0042575,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044776,GO:0046483,GO:0061695,GO:0071704,GO:0071897,GO:0090304,GO:0140097,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234 2.7.7.7 ko:K02337 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon k59_1192645_1 394221.Mmar10_1457 2.5e-62 211.0 COG5616@1|root,COG5616@2|Bacteria,1NSKC@1224|Proteobacteria,2TWZ1@28211|Alphaproteobacteria,44159@69657|Hyphomonadaceae 28211|Alphaproteobacteria K cAMP biosynthetic process - - - - - - - - - - - - Guanylate_cyc,Trans_reg_C k59_514266_1 96561.Dole_2292 1.39e-115 357.0 COG0025@1|root,COG0569@1|root,COG0025@2|Bacteria,COG0569@2|Bacteria,1QTUE@1224|Proteobacteria,43BRM@68525|delta/epsilon subdivisions,2WM4A@28221|Deltaproteobacteria,2MHXR@213118|Desulfobacterales 28221|Deltaproteobacteria P Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family - - - ko:K03316 - - - - ko00000 2.A.36 - - Na_H_Exchanger,TrkA_N k59_1192646_1 322710.Avin_04960 3.52e-32 129.0 COG1629@1|root,COG4771@2|Bacteria,1MUWN@1224|Proteobacteria,1RN1E@1236|Gammaproteobacteria 1236|Gammaproteobacteria P Receptor - - - - - - - - - - - - CarbopepD_reg_2,CarboxypepD_reg,Plug,TonB_dep_Rec k59_1192646_2 395493.BegalDRAFT_3543 2.49e-08 55.5 COG4247@1|root,COG4247@2|Bacteria,1MVTA@1224|Proteobacteria,1RQXH@1236|Gammaproteobacteria,461W5@72273|Thiotrichales 72273|Thiotrichales I 3-phytase (Myo-inositol-hexaphosphate 3-phosphohydrolase) - - 3.1.3.8 ko:K01083 ko00562,map00562 - R03371 RC00078 ko00000,ko00001,ko01000 - - - Phytase k59_345588_1 713586.KB900536_gene908 3.19e-53 176.0 COG0451@1|root,COG0451@2|Bacteria,1MU7J@1224|Proteobacteria,1RPTA@1236|Gammaproteobacteria,1WWHP@135613|Chromatiales 135613|Chromatiales M PFAM NAD-dependent epimerase dehydratase - - 5.1.3.6 ko:K08679 ko00520,ko01100,map00520,map01100 - R01385 RC00289 ko00000,ko00001,ko01000 - - - Epimerase,GDP_Man_Dehyd k59_345588_2 1049564.TevJSym_al00600 1.86e-96 292.0 COG2896@1|root,COG2896@2|Bacteria,1MW3W@1224|Proteobacteria,1RR68@1236|Gammaproteobacteria,1J4WP@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate moaA - 4.1.99.22 ko:K03639 ko00790,ko01100,ko04122,map00790,map01100,map04122 - R09394 RC03420 ko00000,ko00001,ko01000 - - - Fer4_12,Mob_synth_C,Radical_SAM k59_1757420_1 1218075.BAYA01000006_gene2369 3.05e-23 98.6 COG0344@1|root,COG0344@2|Bacteria,1RD4Z@1224|Proteobacteria,2VQ10@28216|Betaproteobacteria,1K08V@119060|Burkholderiaceae 28216|Betaproteobacteria I Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP plsY - 2.3.1.15 ko:K08591 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R00851,R09380 RC00004,RC00039,RC00041 ko00000,ko00001,ko00002,ko01000,ko01004 - - - G3P_acyltransf k59_1475296_1 1123405.AUMM01000010_gene1224 3.26e-92 286.0 COG1884@1|root,COG1884@2|Bacteria,1TQAD@1239|Firmicutes,4H9QB@91061|Bacilli,26P9A@186821|Sporolactobacillaceae 91061|Bacilli I Methylmalonyl-CoA mutase - - 5.4.99.2 ko:K01848 ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200 M00375,M00376,M00741 R00833 RC00395 ko00000,ko00001,ko00002,ko01000 - - - MM_CoA_mutase k59_1305823_1 745014.OMB55_00010730 1.24e-79 251.0 COG1228@1|root,COG1228@2|Bacteria,1MVAF@1224|Proteobacteria,1RQRP@1236|Gammaproteobacteria,1J8WE@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria Q COG1228 Imidazolonepropionase and related amidohydrolases - - - - - - - - - - - - Amidohydro_1 k59_1757427_1 1122137.AQXF01000003_gene2192 1.64e-185 520.0 COG1536@1|root,COG1536@2|Bacteria,1MV9X@1224|Proteobacteria,2TRIV@28211|Alphaproteobacteria 28211|Alphaproteobacteria N FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation fliG - - ko:K02410 ko02030,ko02040,map02030,map02040 - - - ko00000,ko00001,ko02035 - - - FliG_C,FliG_M,FliG_N k59_6457_1 1229909.NSED_08035 1e-109 320.0 COG0720@1|root,arCOG02172@2157|Archaea,41SY8@651137|Thaumarchaeota 651137|Thaumarchaeota H 6-pyruvoyl tetrahydropterin synthase - - 4.1.2.50,4.2.3.12 ko:K01737 ko00790,ko01100,map00790,map01100 M00842,M00843 R04286,R09959 RC01117,RC02846,RC02847 ko00000,ko00001,ko00002,ko01000,ko03016 - - - PTPS k59_1531772_1 1349767.GJA_3034 1.46e-31 127.0 COG3164@1|root,COG3164@2|Bacteria,1QUYX@1224|Proteobacteria,2WGM2@28216|Betaproteobacteria,4791K@75682|Oxalobacteraceae 28216|Betaproteobacteria S Domain of Unknown Function (DUF748) - - - - - - - - - - - - DUF748 k59_458155_1 279238.Saro_0151 2.05e-91 276.0 COG0524@1|root,COG0524@2|Bacteria,1MUUC@1224|Proteobacteria,2TS9D@28211|Alphaproteobacteria,2K0DX@204457|Sphingomonadales 204457|Sphingomonadales G Carbohydrate kinase - - - - - - - - - - - - PfkB k59_63174_1 1500893.JQNB01000001_gene1855 1.5e-158 459.0 COG2987@1|root,COG2987@2|Bacteria,1MU4W@1224|Proteobacteria,1RP89@1236|Gammaproteobacteria,1X3IN@135614|Xanthomonadales 135614|Xanthomonadales E Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate hutU - 4.2.1.49 ko:K01712 ko00340,ko01100,map00340,map01100 M00045 R02914 RC00804 ko00000,ko00001,ko00002,ko01000 - - - Urocanase,Urocanase_C,Urocanase_N k59_1305836_1 439235.Dalk_0147 6.01e-29 113.0 COG2267@1|root,COG2267@2|Bacteria,1MWF5@1224|Proteobacteria,42T8M@68525|delta/epsilon subdivisions,2WPBS@28221|Deltaproteobacteria,2MKKR@213118|Desulfobacterales 28221|Deltaproteobacteria I Alpha beta hydrolase - - - - - - - - - - - - Hydrolase_4 k59_683945_1 566466.NOR53_1560 4.09e-83 270.0 COG0189@1|root,COG0769@1|root,COG0189@2|Bacteria,COG0769@2|Bacteria,1MVN2@1224|Proteobacteria,1RS1C@1236|Gammaproteobacteria,1J57K@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria HJM RimK-like ATP-grasp domain cphA - 6.3.2.29,6.3.2.30 ko:K03802 - - - - ko00000,ko01000 - - - ATP-grasp_5,CPSase_L_D2,Mur_ligase_C,Mur_ligase_M,RimK k59_1023640_1 316407.85675100 9.94e-128 373.0 COG3724@1|root,COG3724@2|Bacteria,1MUJV@1224|Proteobacteria,1RNSS@1236|Gammaproteobacteria,3XMGR@561|Escherichia 1236|Gammaproteobacteria E Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2) astB GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006525,GO:0006527,GO:0006807,GO:0008150,GO:0008152,GO:0009015,GO:0009056,GO:0009063,GO:0009064,GO:0009065,GO:0009987,GO:0016054,GO:0016787,GO:0016810,GO:0016813,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 3.5.3.23 ko:K01484 ko00330,ko01100,map00330,map01100 - R04189 RC00024 ko00000,ko00001,ko01000 - - iECH74115_1262.ECH74115_2463,iECSP_1301.ECSP_2313,iECs_1301.ECs2451,iG2583_1286.G2583_2191 AstB k59_1192667_1 1415755.JQLV01000001_gene2031 5.5e-26 99.0 COG0721@1|root,COG0721@2|Bacteria,1MZQP@1224|Proteobacteria,1S8VY@1236|Gammaproteobacteria,1XMBW@135619|Oceanospirillales 135619|Oceanospirillales J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) gatC - 6.3.5.6,6.3.5.7 ko:K02435 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - Glu-tRNAGln k59_1192667_2 95619.PM1_0206260 1.83e-42 152.0 COG0154@1|root,COG0154@2|Bacteria,1MUVQ@1224|Proteobacteria,1RP7E@1236|Gammaproteobacteria 1236|Gammaproteobacteria J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) gatA - 6.3.5.6,6.3.5.7 ko:K02433 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - Amidase k59_1531789_1 436308.Nmar_0021 7.65e-78 247.0 COG3263@1|root,arCOG01962@2157|Archaea,41SV3@651137|Thaumarchaeota 651137|Thaumarchaeota P Sodium hydrogen exchanger - - - ko:K11105 - - - - ko00000,ko02000 2.A.36.6 - - Na_H_Exchanger k59_1249010_1 1236959.BAMT01000002_gene1909 9.03e-100 293.0 COG0512@1|root,COG0512@2|Bacteria,1MV5Y@1224|Proteobacteria,2VHGQ@28216|Betaproteobacteria,2KMC5@206350|Nitrosomonadales 206350|Nitrosomonadales EH TIGRFAM glutamine amidotransferase of anthranilate synthase - - 4.1.3.27 ko:K01658 ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025 M00023 R00985,R00986 RC00010,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 - - - GATase k59_1249010_2 1288494.EBAPG3_30470 0.000882 40.8 COG0547@1|root,COG0547@2|Bacteria,1MUPV@1224|Proteobacteria,2VH7F@28216|Betaproteobacteria,372M5@32003|Nitrosomonadales 28216|Betaproteobacteria F Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) trpD GO:0000162,GO:0003674,GO:0003824,GO:0004048,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.18 ko:K00766 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R01073 RC00440 ko00000,ko00001,ko00002,ko01000 - - - Glycos_trans_3N,Glycos_transf_3 k59_231929_1 1122137.AQXF01000001_gene2931 3.7e-125 367.0 COG0156@1|root,COG0156@2|Bacteria,1MVVH@1224|Proteobacteria,2TTAK@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide bioF - 2.3.1.47 ko:K00652 ko00780,ko01100,map00780,map01100 M00123,M00573,M00577 R03210,R10124 RC00004,RC00039,RC02725 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 k59_1249013_1 1380394.JADL01000001_gene2407 1.63e-12 67.0 2C7YM@1|root,32RK3@2|Bacteria,1N2IQ@1224|Proteobacteria,2UC0T@28211|Alphaproteobacteria,2JU3A@204441|Rhodospirillales 204441|Rhodospirillales - - - - - - - - - - - - - - - k59_1700865_1 316407.85676393 7.8e-111 337.0 COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,1RN3H@1236|Gammaproteobacteria,3XMC5@561|Escherichia 1236|Gammaproteobacteria F In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance spoT GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0007154,GO:0008150,GO:0008152,GO:0008728,GO:0008893,GO:0009116,GO:0009117,GO:0009119,GO:0009150,GO:0009259,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0015949,GO:0015969,GO:0016020,GO:0016740,GO:0016772,GO:0016778,GO:0016787,GO:0016788,GO:0016794,GO:0019637,GO:0019693,GO:0030312,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0033865,GO:0033875,GO:0034032,GO:0034035,GO:0034641,GO:0042278,GO:0042578,GO:0042594,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046128,GO:0046483,GO:0050896,GO:0051716,GO:0055086,GO:0071496,GO:0071704,GO:0071944,GO:0072521,GO:1901068,GO:1901135,GO:1901360,GO:1901564,GO:1901657 2.7.6.5,3.1.7.2 ko:K00951,ko:K01139 ko00230,map00230 - R00336,R00429 RC00002,RC00078 ko00000,ko00001,ko01000,ko03009 - - iECNA114_1301.ECNA114_3794,iECOK1_1307.ECOK1_4092,iECP_1309.ECP_3748,iECS88_1305.ECS88_4065,iECSF_1327.ECSF_3486,iLF82_1304.LF82_2165,iNRG857_1313.NRG857_18145,iUMN146_1321.UM146_18405,iUTI89_1310.UTI89_C4195,ic_1306.c4475 ACT_4,HD_4,RelA_SpoT,TGS k59_1192678_1 1392490.JHZX01000001_gene2729 1.16e-72 246.0 COG2771@1|root,COG3292@1|root,COG2771@2|Bacteria,COG3292@2|Bacteria,4PKBX@976|Bacteroidetes,1HWMG@117743|Flavobacteriia 976|Bacteroidetes KT Two component regulator three Y - - - - - - - - - - - - GerE k59_627618_1 1209072.ALBT01000064_gene1165 4.01e-69 227.0 COG1290@1|root,COG2857@1|root,COG1290@2|Bacteria,COG2857@2|Bacteria,1MV97@1224|Proteobacteria,1RNCP@1236|Gammaproteobacteria,1FH2R@10|Cellvibrio 1236|Gammaproteobacteria C Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis petB - - ko:K00412 ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016 M00151,M00152 - - ko00000,ko00001,ko00002,ko03029 - - - Cytochrom_B_C,Cytochrom_C1,Cytochrome_B k59_627618_2 1279017.AQYJ01000024_gene1063 2.07e-100 295.0 COG0723@1|root,COG0723@2|Bacteria,1RAA2@1224|Proteobacteria,1RP9H@1236|Gammaproteobacteria,465S7@72275|Alteromonadaceae 1236|Gammaproteobacteria C Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis petA - 1.10.2.2 ko:K00411 ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016 M00151,M00152 - - ko00000,ko00001,ko00002,ko01000 - - - Rieske,UCR_Fe-S_N k59_345633_1 436308.Nmar_1452 2.13e-22 90.5 arCOG05529@1|root,arCOG05529@2157|Archaea,41SSJ@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - dsDNA_bind k59_345633_2 1229909.NSED_07985 2.6e-59 196.0 COG1690@1|root,arCOG04246@2157|Archaea,41SE4@651137|Thaumarchaeota 651137|Thaumarchaeota S Belongs to the RtcB family rtcB - 6.5.1.3 ko:K14415 - - - - ko00000,ko01000,ko03016 - - - RtcB k59_1426855_1 639283.Snov_0063 5.65e-74 238.0 COG0076@1|root,COG0076@2|Bacteria,1MWUX@1224|Proteobacteria,2TTUK@28211|Alphaproteobacteria,3EZS1@335928|Xanthobacteraceae 28211|Alphaproteobacteria E Pyridoxal-dependent decarboxylase conserved domain rhbB - 4.1.1.105,4.1.1.28 ko:K01593 ko00350,ko00360,ko00380,ko00901,ko00950,ko00965,ko01100,ko01110,ko04726,ko04728,ko05030,ko05031,ko05034,map00350,map00360,map00380,map00901,map00950,map00965,map01100,map01110,map04726,map04728,map05030,map05031,map05034 M00037,M00042 R00685,R00699,R00736,R02080,R02701,R04909 RC00299 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Pyridoxal_deC k59_1484478_1 1408823.AXUS01000021_gene2479 3.09e-22 99.8 COG1574@1|root,COG1574@2|Bacteria,1UY5C@1239|Firmicutes,24A2S@186801|Clostridia 186801|Clostridia S Acyclic terpene utilisation family protein AtuA - - - - - - - - - - - - AtuA k59_1540516_1 502025.Hoch_5252 2.24e-80 268.0 COG0745@1|root,COG1340@1|root,COG1352@1|root,COG2201@1|root,COG2203@1|root,COG5002@1|root,COG0745@2|Bacteria,COG1340@2|Bacteria,COG1352@2|Bacteria,COG2201@2|Bacteria,COG2203@2|Bacteria,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,42NK9@68525|delta/epsilon subdivisions,2WMCQ@28221|Deltaproteobacteria 28221|Deltaproteobacteria T Response regulator receiver - - 2.1.1.80,3.1.1.61 ko:K13924 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko02022,ko02035 - - - CheB_methylest,CheR,CheR_N,GAF_2,HATPase_c,HisKA,PAS_10,PAS_3,PAS_4,PAS_9,Response_reg k59_579629_1 983920.Y88_2591 3.17e-78 234.0 COG1393@1|root,COG1393@2|Bacteria,1MZ4Z@1224|Proteobacteria,2U70U@28211|Alphaproteobacteria,2K413@204457|Sphingomonadales 204457|Sphingomonadales P arsenate reductase - - - - - - - - - - - - ArsC k59_1596539_1 1348657.M622_12315 2.75e-75 240.0 COG2211@1|root,COG2211@2|Bacteria,1MWSH@1224|Proteobacteria,2VJEQ@28216|Betaproteobacteria,2KUQ3@206389|Rhodocyclales 206389|Rhodocyclales G BT1 family - - - - - - - - - - - - BT1 k59_522632_2 59538.XP_005979110.1 4.36e-47 165.0 COG0365@1|root,KOG1175@2759|Eukaryota,38H1A@33154|Opisthokonta,3BA8B@33208|Metazoa,3CZAD@33213|Bilateria,4866V@7711|Chordata,495G8@7742|Vertebrata,3J71H@40674|Mammalia 33154|Opisthokonta I butyrate-CoA ligase activity - - - - - - - - - - - - AMP-binding,AMP-binding_C k59_1088085_1 871963.Desdi_0397 1.62e-11 65.5 COG0589@1|root,COG0589@2|Bacteria,1VEJR@1239|Firmicutes,24QQ6@186801|Clostridia,265CG@186807|Peptococcaceae 186801|Clostridia T PFAM Universal stress protein family - - - - - - - - - - - - Usp k59_1088085_2 205922.Pfl01_3735 2.91e-16 78.2 COG2905@1|root,COG2905@2|Bacteria,1QTTR@1224|Proteobacteria,1SBBF@1236|Gammaproteobacteria,1YQ9G@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria T Domain in cystathionine beta-synthase and other proteins. - - - - - - - - - - - - CBS k59_72166_1 696281.Desru_3616 0.000106 49.3 COG1573@1|root,COG1573@2|Bacteria,1V267@1239|Firmicutes,24DFW@186801|Clostridia,261VB@186807|Peptococcaceae 186801|Clostridia L TIGRFAM Phage SPO1 DNA polymerase-related protein - - 3.2.2.27 ko:K21929 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - UDG k59_297976_1 1122137.AQXF01000003_gene2287 7.7e-98 300.0 COG0769@1|root,COG0769@2|Bacteria,1MU6P@1224|Proteobacteria,2TVXI@28211|Alphaproteobacteria 28211|Alphaproteobacteria M Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan murE - 6.3.2.13 ko:K01928 ko00300,ko00550,map00300,map00550 - R02788 RC00064,RC00090 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_863242_1 936136.ARRT01000005_gene199 9.45e-83 258.0 COG1861@1|root,COG1861@2|Bacteria,1QU5J@1224|Proteobacteria,2U0ZH@28211|Alphaproteobacteria,4BJ1H@82115|Rhizobiaceae 28211|Alphaproteobacteria L Transposase DDE domain group 1 - - - - - - - - - - - - DDE_Tnp_1_4 k59_128213_1 497964.CfE428DRAFT_4093 2.6e-72 244.0 COG0506@1|root,COG1012@1|root,COG0506@2|Bacteria,COG1012@2|Bacteria,46SAP@74201|Verrucomicrobia 74201|Verrucomicrobia CE Proline dehydrogenase - - 1.2.1.88,1.5.5.2 ko:K13821 ko00250,ko00330,ko01100,ko01110,ko01130,map00250,map00330,map01100,map01110,map01130 - R00245,R00707,R00708,R01253,R04444,R04445,R05051 RC00080,RC00083,RC00216,RC00242,RC00255 ko00000,ko00001,ko01000,ko03000 - - - Aldedh,Pro_dh,Pro_dh-DNA_bdg k59_1540531_1 391603.FBALC1_15812 1.5e-116 346.0 COG0172@1|root,COG0172@2|Bacteria,4NED6@976|Bacteroidetes,1HY6A@117743|Flavobacteriia 976|Bacteroidetes J seryl-tRNA synthetase serS - 6.1.1.11 ko:K01875 ko00970,map00970 M00359,M00360 R03662,R08218 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Seryl_tRNA_N,tRNA-synt_2b k59_918688_1 247639.MGP2080_09528 2.85e-25 103.0 COG1595@1|root,COG1595@2|Bacteria,1MX7T@1224|Proteobacteria,1RN64@1236|Gammaproteobacteria,1J5Q9@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria K Belongs to the sigma-70 factor family. ECF subfamily rpoE GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006355,GO:0006950,GO:0006970,GO:0008150,GO:0009266,GO:0009628,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0044424,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:1903506,GO:2000112,GO:2001141 - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 k59_1032512_1 555793.WSK_2404 3.25e-38 139.0 COG1520@1|root,COG1520@2|Bacteria,1MXIJ@1224|Proteobacteria,2TUAD@28211|Alphaproteobacteria,2K0GW@204457|Sphingomonadales 204457|Sphingomonadales S Pyrrolo-quinoline quinone - - - - - - - - - - - - PQQ_2,PQQ_3 k59_1032512_2 1331060.RLDS_20705 6.17e-27 110.0 COG2020@1|root,COG2020@2|Bacteria,1R55E@1224|Proteobacteria,2U75X@28211|Alphaproteobacteria,2K0AU@204457|Sphingomonadales 204457|Sphingomonadales O protein-S-isoprenylcysteine methyltransferase - - - - - - - - - - - - DUF1295,ICMT k59_748935_1 222534.KB893728_gene5639 1.35e-84 267.0 COG3386@1|root,COG3386@2|Bacteria,2GNM1@201174|Actinobacteria 201174|Actinobacteria G PFAM NHL repeat containing protein - - - - - - - - - - - - SGL k59_748935_2 1155718.KB891893_gene7247 4.21e-05 47.0 COG0318@1|root,COG0318@2|Bacteria,2GIUC@201174|Actinobacteria 201174|Actinobacteria IQ PFAM AMP-dependent synthetase and ligase - - - ko:K00666 - - - - ko00000,ko01000,ko01004 - - - AMP-binding,AMP-binding_C k59_410187_1 426117.M446_0635 7.67e-09 62.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,2TQR7@28211|Alphaproteobacteria,1JRN3@119045|Methylobacteriaceae 28211|Alphaproteobacteria NT PFAM histidine kinase HAMP region domain protein - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - 4HB_MCP_1,HAMP,MCPsignal,dCache_1,sCache_2 k59_806155_1 305700.B447_08258 1.86e-147 457.0 COG1429@1|root,COG1429@2|Bacteria,1MU5W@1224|Proteobacteria,2VI5I@28216|Betaproteobacteria,2KUI5@206389|Rhodocyclales 206389|Rhodocyclales H COG1429 Cobalamin biosynthesis protein CobN and related Mg-chelatases - - - - - - - - - - - - CobN-Mg_chel k59_1088121_1 1219035.NT2_12_00270 8.2e-48 162.0 COG0451@1|root,COG0451@2|Bacteria,1NM1U@1224|Proteobacteria,2U6U3@28211|Alphaproteobacteria,2K2HM@204457|Sphingomonadales 204457|Sphingomonadales GM NAD-dependent epimerase dehydratase - - - - - - - - - - - - Epimerase k59_1540556_1 1006000.GKAS_02479 8.19e-35 131.0 COG1066@1|root,COG1066@2|Bacteria,1MUJQ@1224|Proteobacteria,1RN2E@1236|Gammaproteobacteria 1236|Gammaproteobacteria O DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function radA GO:0000725,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009314,GO:0009628,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363 - ko:K04485 - - - - ko00000,ko03400 - - - AAA_25,ATPase,ChlI k59_1540556_2 631362.Thi970DRAFT_03247 2.45e-12 67.0 COG4536@1|root,COG4536@2|Bacteria,1NZ99@1224|Proteobacteria,1RNCE@1236|Gammaproteobacteria,1WWQM@135613|Chromatiales 135613|Chromatiales P CBS domain - - - - - - - - - - - - CBS,CorC_HlyC,DUF21 k59_1766133_1 1122137.AQXF01000003_gene2395 2.86e-114 343.0 COG0459@1|root,COG0459@2|Bacteria,1MURR@1224|Proteobacteria,2TS07@28211|Alphaproteobacteria 28211|Alphaproteobacteria O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions groL - - ko:K04077 ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 - - - Cpn60_TCP1 k59_1540559_1 414684.RC1_3711 2.47e-17 92.0 COG1629@1|root,COG4771@2|Bacteria,1MWKN@1224|Proteobacteria,2UPP1@28211|Alphaproteobacteria 28211|Alphaproteobacteria P TonB-dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_1653613_1 1382304.JNIL01000001_gene3155 3.29e-05 47.4 COG1213@1|root,COG1213@2|Bacteria,1W72F@1239|Firmicutes,4IQVP@91061|Bacilli 91061|Bacilli M Nucleotidyl transferase - - - - - - - - - - - - NTP_transf_3 k59_1709567_1 493475.GARC_4256 7.01e-163 494.0 COG1629@1|root,COG4771@2|Bacteria,1MU9K@1224|Proteobacteria,1RMTG@1236|Gammaproteobacteria 1236|Gammaproteobacteria P Receptor - - - - - - - - - - - - Plug,TonB_dep_Rec k59_128247_1 1449049.JONW01000005_gene1782 4.54e-55 184.0 COG2382@1|root,COG2382@2|Bacteria,1QX0K@1224|Proteobacteria,2V4YB@28211|Alphaproteobacteria,2KHTK@204458|Caulobacterales 204458|Caulobacterales P Putative esterase - - - - - - - - - - - - Esterase k59_1426902_1 330214.NIDE0469 8.82e-57 181.0 COG0225@1|root,COG0225@2|Bacteria,3J12A@40117|Nitrospirae 40117|Nitrospirae C Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine - - 1.8.4.11 ko:K07304 - - - - ko00000,ko01000 - - - PMSR k59_1766154_1 1229909.NSED_05735 3.84e-37 130.0 COG0589@1|root,arCOG02053@2157|Archaea,41TB2@651137|Thaumarchaeota 651137|Thaumarchaeota T COG0589 Universal stress protein UspA and related nucleotide-binding proteins - - - - - - - - - - - - Usp k59_1766154_2 1229909.NSED_08010 7.78e-41 139.0 COG0517@1|root,arCOG00606@2157|Archaea,41T8N@651137|Thaumarchaeota 651137|Thaumarchaeota S CBS domain - - - - - - - - - - - - CBS k59_184657_1 1121937.AUHJ01000017_gene3009 2.39e-37 144.0 COG1262@1|root,COG1262@2|Bacteria,1NQ5K@1224|Proteobacteria,1RQVS@1236|Gammaproteobacteria,46674@72275|Alteromonadaceae 1236|Gammaproteobacteria S PEGA domain - - - - - - - - - - - - FGE-sulfatase,PEGA k59_1426915_1 247634.GPB2148_2781 1.56e-33 127.0 COG4783@1|root,COG4783@2|Bacteria,1MVFV@1224|Proteobacteria,1RP5S@1236|Gammaproteobacteria,1J5N2@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Functions as both a chaperone and a metalloprotease. Maintains the integrity of the outer membrane by promoting either the assembly or the elimination of outer membrane proteins, depending on their folding state bepA GO:0003674,GO:0003756,GO:0003824,GO:0004175,GO:0004222,GO:0005488,GO:0005575,GO:0005623,GO:0006457,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009056,GO:0009057,GO:0009987,GO:0016020,GO:0016043,GO:0016787,GO:0016853,GO:0016860,GO:0016864,GO:0019538,GO:0022607,GO:0030163,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043163,GO:0043165,GO:0043167,GO:0043169,GO:0043170,GO:0044085,GO:0044091,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044464,GO:0045229,GO:0046872,GO:0051603,GO:0061024,GO:0061077,GO:0070011,GO:0071704,GO:0071709,GO:0071840,GO:0140096,GO:1901564,GO:1901565,GO:1901575 - - - - - - - - - - Peptidase_M48,TPR_19 k59_1426915_2 566466.NOR53_144 2.64e-29 113.0 COG0379@1|root,COG0379@2|Bacteria,1MWQU@1224|Proteobacteria,1RMFS@1236|Gammaproteobacteria,1J56G@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate nadA GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006734,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008987,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016053,GO:0017144,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0019805,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046496,GO:0046874,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.5.1.72 ko:K03517 ko00760,ko01100,map00760,map01100 M00115 R04292 RC01119 ko00000,ko00001,ko00002,ko01000 - - iAF1260.b0750,iAPECO1_1312.APECO1_1338,iB21_1397.B21_00692,iBWG_1329.BWG_0602,iECBD_1354.ECBD_2917,iECB_1328.ECB_00703,iECDH10B_1368.ECDH10B_0817,iECDH1ME8569_1439.ECDH1ME8569_0703,iECD_1391.ECD_00703,iECED1_1282.ECED1_0711,iECOK1_1307.ECOK1_0750,iECP_1309.ECP_0761,iECS88_1305.ECS88_0766,iECSP_1301.ECSP_0802,iECs_1301.ECs0778,iETEC_1333.ETEC_0754,iEcDH1_1363.EcDH1_2892,iEcolC_1368.EcolC_2912,iJN746.PP_1231,iJO1366.b0750,iJR904.b0750,iUMN146_1321.UM146_13905,iUTI89_1310.UTI89_C0747,iY75_1357.Y75_RS03905,iZ_1308.Z0919 NadA k59_298043_1 558884.JRGM01000017_gene2550 2.48e-21 90.9 COG1238@1|root,COG1238@2|Bacteria,1RHUV@1224|Proteobacteria,1S9G4@1236|Gammaproteobacteria,1Y4VP@135624|Aeromonadales 135624|Aeromonadales S SNARE associated Golgi protein - - - - - - - - - - - - SNARE_assoc k59_1709592_1 76114.ebA1090 4.01e-46 162.0 COG0548@1|root,COG1246@1|root,COG0548@2|Bacteria,COG1246@2|Bacteria,1MUUP@1224|Proteobacteria,2VGZC@28216|Betaproteobacteria,2KUN4@206389|Rhodocyclales 206389|Rhodocyclales E Belongs to the acetyltransferase family. ArgA subfamily argA - 2.3.1.1 ko:K14682 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028 R00259 RC00004,RC00064 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase,Acetyltransf_1 k59_1371283_1 861360.AARI_18890 2.73e-16 83.6 COG0166@1|root,COG0166@2|Bacteria,2HT2Q@201174|Actinobacteria,1W8PK@1268|Micrococcaceae 201174|Actinobacteria G Belongs to the GPI family pgi - 5.3.1.9 ko:K01810 ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200 M00001,M00004,M00114 R02739,R02740,R03321 RC00376,RC00563 ko00000,ko00001,ko00002,ko01000,ko04147 - - - PGI k59_354530_1 443144.GM21_0509 6.45e-124 366.0 COG0773@1|root,COG0773@2|Bacteria,1MV68@1224|Proteobacteria,42MMP@68525|delta/epsilon subdivisions,2WK50@28221|Deltaproteobacteria 28221|Deltaproteobacteria M Belongs to the MurCDEF family murC - 6.3.2.8 ko:K01924 ko00471,ko00550,ko01100,map00471,map00550,map01100 - R03193 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_1596640_1 316407.85676858 2.63e-113 329.0 COG3638@1|root,COG3638@2|Bacteria,1MVE9@1224|Proteobacteria,1RRV7@1236|Gammaproteobacteria,3XRIR@561|Escherichia 1236|Gammaproteobacteria P Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system phnC - 3.6.3.28 ko:K02041 ko02010,map02010 M00223 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.9 - - ABC_tran k59_1371289_1 1207055.C100_13710 1.05e-134 414.0 COG3250@1|root,COG3250@2|Bacteria,1P9KJ@1224|Proteobacteria,2TV5M@28211|Alphaproteobacteria,2K34U@204457|Sphingomonadales 204457|Sphingomonadales G alpha-L-rhamnosidase - - - - - - - - - - - - Glyco_hydro_106 k59_579721_1 1122137.AQXF01000004_gene1437 1.39e-150 426.0 COG0396@1|root,COG0396@2|Bacteria,1MUGK@1224|Proteobacteria,2TS8T@28211|Alphaproteobacteria 28211|Alphaproteobacteria O FeS assembly ATPase SufC sufC GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006790,GO:0008150,GO:0008152,GO:0009314,GO:0009628,GO:0009987,GO:0016043,GO:0016226,GO:0022607,GO:0031163,GO:0044085,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051186,GO:0071840 - ko:K09013 - - - - ko00000,ko02000 - - - ABC_tran k59_1032595_1 555793.WSK_0799 5.04e-134 387.0 COG2267@1|root,COG2267@2|Bacteria,1RATF@1224|Proteobacteria,2TTCT@28211|Alphaproteobacteria,2K1SM@204457|Sphingomonadales 204457|Sphingomonadales I Alpha beta hydrolase - - - ko:K18092 ko00642,ko01100,ko01120,ko01220,map00642,map01100,map01120,map01220 - R05366 RC00752,RC00753 br01602,ko00000,ko00001,ko01000 - - - Abhydrolase_1,Abhydrolase_6 k59_1032595_2 555793.WSK_0773 2.88e-16 77.4 COG0654@1|root,COG0654@2|Bacteria,1MUN4@1224|Proteobacteria,2TQT8@28211|Alphaproteobacteria,2KCQI@204457|Sphingomonadales 28211|Alphaproteobacteria CH FAD binding domain - - 1.14.13.127 ko:K05712 ko00360,ko01120,ko01220,map00360,map01120,map01220 M00545 R06786,R06787 RC00236 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_3 k59_1653651_1 1035191.HMPREF0185_00073 1.32e-46 170.0 COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,2TRJF@28211|Alphaproteobacteria,2KF96@204458|Caulobacterales 204458|Caulobacterales L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity polA - 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1 k59_1596646_1 1121937.AUHJ01000004_gene1008 2.54e-82 251.0 COG4638@1|root,COG4638@2|Bacteria,1R5AZ@1224|Proteobacteria,1RMCT@1236|Gammaproteobacteria 1236|Gammaproteobacteria P COG4638 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit - - - - - - - - - - - - Rieske k59_1709604_1 314285.KT71_11845 3.24e-70 220.0 COG1063@1|root,COG1063@2|Bacteria,1MV9A@1224|Proteobacteria,1RMNY@1236|Gammaproteobacteria,1J8D4@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Catalyzes the NAD( )-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate tdh GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006563,GO:0006564,GO:0006566,GO:0006567,GO:0006807,GO:0008150,GO:0008152,GO:0008198,GO:0008270,GO:0008652,GO:0008743,GO:0009056,GO:0009058,GO:0009063,GO:0009066,GO:0009068,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016054,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0030145,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046395,GO:0046870,GO:0046872,GO:0046914,GO:0055114,GO:0071704,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1901607 1.1.1.103 ko:K00060 ko00260,map00260 - R01465 RC00525 ko00000,ko00001,ko01000 - - iEC042_1314.EC042_3926,iECUMN_1333.ECUMN_4133,iPC815.YPO0060 ADH_N,ADH_zinc_N k59_974457_1 248742.XP_005645237.1 1.13e-06 57.4 COG0705@1|root,KOG2289@2759|Eukaryota,37I42@33090|Viridiplantae,34M24@3041|Chlorophyta 3041|Chlorophyta T Rhomboid family - - - - - - - - - - - - Rhomboid k59_298063_1 886377.Murru_0218 6.16e-94 286.0 COG2204@1|root,COG2204@2|Bacteria,4NE89@976|Bacteroidetes,1HWWK@117743|Flavobacteriia 976|Bacteroidetes T COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains - - - ko:K07713 ko02020,map02020 M00499 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_918751_1 243233.MCA0333 3.4e-27 103.0 COG0494@1|root,COG0494@2|Bacteria,1RCX7@1224|Proteobacteria,1RSM2@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Belongs to the Nudix hydrolase family - - 3.6.1.13 ko:K01515 ko00230,map00230 - R01054 RC00002 ko00000,ko00001,ko01000 - - - NUDIX k59_918751_2 1117647.M5M_08565 5.95e-26 107.0 COG0534@1|root,COG0534@2|Bacteria,1MVRV@1224|Proteobacteria,1RRDQ@1236|Gammaproteobacteria,1J5T4@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria V COG0534 Na -driven multidrug efflux pump - - - - - - - - - - - - MatE k59_636271_1 1122137.AQXF01000001_gene2837 7.24e-81 244.0 COG1238@1|root,COG1238@2|Bacteria,1MWED@1224|Proteobacteria,2U78A@28211|Alphaproteobacteria 28211|Alphaproteobacteria O DedA family MA20_20865 - - - - - - - - - - - SNARE_assoc k59_1201443_1 519989.ECTPHS_01709 1.04e-90 281.0 COG0530@1|root,COG0530@2|Bacteria,1MU3R@1224|Proteobacteria,1RMRD@1236|Gammaproteobacteria,1WXKK@135613|Chromatiales 135613|Chromatiales P Sodium/calcium exchanger protein - - - ko:K07301 - - - - ko00000,ko02000 2.A.19.5 - - Na_Ca_ex k59_72272_1 215803.DB30_1082 8.67e-07 54.7 COG0715@1|root,COG0715@2|Bacteria,1MVJA@1224|Proteobacteria,42UZS@68525|delta/epsilon subdivisions,2X77T@28221|Deltaproteobacteria,2YVJW@29|Myxococcales 28221|Deltaproteobacteria P NMT1-like family - - - ko:K02051,ko:K15551 ko00920,ko02010,map00920,map02010 M00188,M00435 - - ko00000,ko00001,ko00002,ko02000 3.A.1.16,3.A.1.17,3.A.1.17.1,3.A.1.17.4 - - NMT1,NMT1_2 k59_72272_2 391616.OA238_c46030 4e-28 127.0 COG0642@1|root,COG0784@1|root,COG2198@1|root,COG0784@2|Bacteria,COG2198@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria 1224|Proteobacteria T Histidine kinase - - 2.7.13.3 ko:K20974 ko02020,ko02025,map02020,map02025 M00820 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA,Hpt,PAS,PAS_9,Response_reg k59_1201453_2 314278.NB231_09883 5.58e-82 254.0 COG3551@1|root,COG3551@2|Bacteria,1MYJC@1224|Proteobacteria,1S8FM@1236|Gammaproteobacteria,1X1UW@135613|Chromatiales 135613|Chromatiales S Sulfotransferase family - - - - - - - - - - - - Sulfotransfer_3 k59_1144484_1 1207063.P24_18002 1.89e-145 421.0 COG0624@1|root,COG0624@2|Bacteria,1MW2W@1224|Proteobacteria,2TQYZ@28211|Alphaproteobacteria,2JPP8@204441|Rhodospirillales 204441|Rhodospirillales E Peptidase dimerisation domain - - 3.5.1.16 ko:K01438 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028,M00845 R00669,R09107 RC00064,RC00300 ko00000,ko00001,ko00002,ko01000 - - - M20_dimer,Peptidase_M20 k59_1032635_1 1317118.ATO8_08341 9.08e-45 162.0 COG0451@1|root,COG2227@1|root,COG0451@2|Bacteria,COG2227@2|Bacteria,1QU62@1224|Proteobacteria,2TW17@28211|Alphaproteobacteria 28211|Alphaproteobacteria H Methyltransferase - - - - - - - - - - - - Methyltransf_13,Methyltransf_14,Methyltransf_23 k59_1032635_2 383372.Rcas_3094 3.46e-133 382.0 COG1208@1|root,COG1208@2|Bacteria,2G863@200795|Chloroflexi,376T1@32061|Chloroflexia 32061|Chloroflexia M TIGRFAM glucose-1-phosphate cytidylyltransferase - - 2.7.7.33 ko:K00978 ko00500,ko00520,ko01100,map00500,map00520,map01100 - R00956 RC00002 ko00000,ko00001,ko01000 - - - NTP_transferase k59_579767_1 65497.JODV01000005_gene1069 1.45e-06 50.8 COG0346@1|root,COG0346@2|Bacteria,2IHYP@201174|Actinobacteria,4E3KN@85010|Pseudonocardiales 201174|Actinobacteria E PFAM Glyoxalase bleomycin resistance protein dioxygenase - - - - - - - - - - - - Glyoxalase k59_579767_2 290397.Adeh_0976 0.000766 41.6 COG0477@1|root,COG2814@2|Bacteria,1MW19@1224|Proteobacteria,42KZ4@68525|delta/epsilon subdivisions,2WKT2@28221|Deltaproteobacteria 28221|Deltaproteobacteria EGP drug resistance transporter, Bcr CflA - - - ko:K07552 - - - - ko00000,ko02000 2.A.1.2 - - MFS_1 k59_1596698_1 1120983.KB894570_gene1876 2.69e-118 346.0 COG0031@1|root,COG0031@2|Bacteria,1MUBE@1224|Proteobacteria,2TR4W@28211|Alphaproteobacteria,1JNEK@119043|Rhodobiaceae 28211|Alphaproteobacteria E Pyridoxal-phosphate dependent enzyme cysB GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004124,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0019344,GO:0019752,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.5.1.47 ko:K01738 ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230 M00021 R00897,R03601,R04859 RC00020,RC02814,RC02821 ko00000,ko00001,ko00002,ko01000 - - - PALP k59_636311_1 1088721.NSU_1755 1.56e-72 224.0 2BJB4@1|root,32DM3@2|Bacteria,1N0RM@1224|Proteobacteria,2UC21@28211|Alphaproteobacteria,2KDJP@204457|Sphingomonadales 204457|Sphingomonadales - - - - - - - - - - - - - - - k59_522739_1 1396141.BATP01000035_gene4003 2.57e-65 224.0 COG0457@1|root,COG0457@2|Bacteria,46U2J@74201|Verrucomicrobia,2IV5B@203494|Verrucomicrobiae 203494|Verrucomicrobiae S Domain of unknown function (DUF5107) - - - - - - - - - - - - DUF5107,TPR_8 k59_354603_1 1267535.KB906767_gene2455 6.85e-92 295.0 COG2010@1|root,COG2010@2|Bacteria,3Y31J@57723|Acidobacteria,2JKC9@204432|Acidobacteriia 204432|Acidobacteriia C Cytochrome c - - - - - - - - - - - - - k59_1653719_1 1229909.NSED_09440 6.78e-249 691.0 COG0004@1|root,arCOG04397@2157|Archaea,41SZ0@651137|Thaumarchaeota 651137|Thaumarchaeota P Ammonium Transporter - - - ko:K03320 - - - - ko00000,ko02000 1.A.11 - - Ammonium_transp k59_1653719_2 1229909.NSED_09360 3.47e-08 53.1 arCOG08749@1|root,arCOG08749@2157|Archaea,41SRV@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_636318_1 1123377.AUIV01000025_gene395 1.77e-10 60.1 COG0321@1|root,COG0321@2|Bacteria,1MU6A@1224|Proteobacteria,1RMXQ@1236|Gammaproteobacteria,1X4H1@135614|Xanthomonadales 135614|Xanthomonadales H Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate lipB GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009249,GO:0009987,GO:0010467,GO:0018065,GO:0018193,GO:0018205,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0051604,GO:0071704,GO:1901564 2.3.1.181 ko:K03801 ko00785,ko01100,map00785,map01100 - R07766,R07769 RC00039,RC00992,RC02867 ko00000,ko00001,ko01000 - - - BPL_LplA_LipB k59_636318_2 626418.bglu_1g32070 1.38e-22 90.5 COG2921@1|root,COG2921@2|Bacteria,1RGV5@1224|Proteobacteria,2VTY5@28216|Betaproteobacteria,1K9EN@119060|Burkholderiaceae 28216|Betaproteobacteria S Belongs to the UPF0250 family ybeD - - ko:K09158 - - - - ko00000 - - - DUF493 k59_636318_3 1123401.JHYQ01000036_gene1676 1.7e-24 104.0 COG1686@1|root,COG1686@2|Bacteria,1MUU7@1224|Proteobacteria,1RMJA@1236|Gammaproteobacteria,4602E@72273|Thiotrichales 72273|Thiotrichales M Belongs to the peptidase S11 family - - 3.4.16.4 ko:K07258 ko00550,ko01100,map00550,map01100 - - - ko00000,ko00001,ko01000,ko01002,ko01011 - - - PBP5_C,Peptidase_S11 k59_1596708_1 309801.trd_A0663 1.29e-58 185.0 COG0251@1|root,COG0251@2|Bacteria,2G7G4@200795|Chloroflexi,27Y7P@189775|Thermomicrobia 189775|Thermomicrobia J YjgF/chorismate_mutase-like, putative endoribonuclease - - - - - - - - - - - - YjgF_endoribonc k59_1596708_2 444157.Tneu_1281 5.44e-11 62.8 COG0277@1|root,arCOG00337@2157|Archaea,2XPUS@28889|Crenarchaeota 28889|Crenarchaeota C PFAM FAD linked oxidase domain protein loxD - 1.1.2.4,1.1.3.15 ko:K00102,ko:K00104 ko00620,ko00630,ko01100,ko01110,ko01120,ko01130,map00620,map00630,map01100,map01110,map01120,map01130 - R00197,R00475 RC00042,RC00044 ko00000,ko00001,ko01000 - - - FAD-oxidase_C,FAD_binding_4 k59_1145686_1 1046627.BZARG_1348 9.73e-61 194.0 COG1162@1|root,COG1162@2|Bacteria,4NE5H@976|Bacteroidetes,1HX6Y@117743|Flavobacteriia 976|Bacteroidetes S One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit rsgA - 3.1.3.100 ko:K06949 ko00730,ko01100,map00730,map01100 - R00615,R02135 RC00002,RC00017 ko00000,ko00001,ko01000,ko03009 - - - RsgA_GTPase,RsgA_N k59_1145686_2 983544.Lacal_0453 9.3e-45 149.0 COG1490@1|root,COG1490@2|Bacteria,4NNFF@976|Bacteroidetes,1I1XN@117743|Flavobacteriia 976|Bacteroidetes J rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality dtd GO:0002161,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006399,GO:0006450,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0034641,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0051499,GO:0051500,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360 - ko:K07560 - - - - ko00000,ko01000,ko03016 - - - Tyr_Deacylase k59_73489_1 1122603.ATVI01000005_gene3501 2.87e-23 109.0 COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,1SZ6C@1236|Gammaproteobacteria,1XCCV@135614|Xanthomonadales 1236|Gammaproteobacteria T Tetratricopeptide repeat - - - - - - - - - - - - Guanylate_cyc,TPR_19,TPR_2,TPR_8 k59_1710934_1 385682.AFSL01000015_gene2715 1.34e-12 70.9 COG0038@1|root,COG0038@2|Bacteria,4NZYS@976|Bacteroidetes,2G0DB@200643|Bacteroidia,3XJBX@558415|Marinilabiliaceae 976|Bacteroidetes P Protein of unknown function (DUF2723) - - - - - - - - - - - - DUF2723 k59_1485764_1 1265313.HRUBRA_02126 6.51e-68 227.0 COG4774@1|root,COG4774@2|Bacteria,1RBVQ@1224|Proteobacteria,1SMVM@1236|Gammaproteobacteria,1J8EM@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P TonB-dependent Receptor Plug Domain - - - - - - - - - - - - Plug k59_73513_1 1123367.C666_15055 1.64e-52 178.0 COG4638@1|root,COG4638@2|Bacteria,1MWXW@1224|Proteobacteria,2VJT8@28216|Betaproteobacteria 28216|Betaproteobacteria P Rieske 2Fe-2S - - - - - - - - - - - - Rieske,Ring_hydroxyl_A k59_1258839_1 1096930.L284_15605 6.73e-31 118.0 COG0772@1|root,COG0772@2|Bacteria,1MUK3@1224|Proteobacteria,2TSM0@28211|Alphaproteobacteria,2K0FR@204457|Sphingomonadales 204457|Sphingomonadales M Peptidoglycan polymerase that is essential for cell wall elongation mrdB - - ko:K05837 - - - - ko00000,ko03036 - - - FTSW_RODA_SPOVE k59_1258839_2 702113.PP1Y_AT25112 4.99e-16 79.3 COG0768@1|root,COG0768@2|Bacteria,1MV8C@1224|Proteobacteria,2TRXN@28211|Alphaproteobacteria,2JZYI@204457|Sphingomonadales 204457|Sphingomonadales M Penicillin-binding Protein mrdA - 3.4.16.4 ko:K05515 ko00550,ko01501,map00550,map01501 - - - ko00000,ko00001,ko01000,ko01011 - - - PBP_dimer,Transpeptidase k59_757124_1 519989.ECTPHS_06532 9.18e-86 263.0 COG0533@1|root,COG0533@2|Bacteria,1MU6S@1224|Proteobacteria,1RN8M@1236|Gammaproteobacteria,1WWRX@135613|Chromatiales 135613|Chromatiales O Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction tsaD - 2.3.1.234 ko:K01409 - - R10648 RC00070,RC00416 ko00000,ko01000,ko03016 - - - Peptidase_M22 k59_1096471_1 247490.KSU1_C1040 8.52e-51 181.0 COG0474@1|root,COG0474@2|Bacteria,2IXV7@203682|Planctomycetes 203682|Planctomycetes P TIGRFAM ATPase, P-type (transporting), HAD superfamily, subfamily IC - - 3.6.3.2 ko:K01531 - - - - ko00000,ko01000 3.A.3.4 - - Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,SBP_bac_1 k59_1380681_1 1003200.AXXA_18136 1.35e-48 164.0 COG0031@1|root,COG0031@2|Bacteria,1MUBE@1224|Proteobacteria,2VH7B@28216|Betaproteobacteria,3T1YM@506|Alcaligenaceae 28216|Betaproteobacteria E Belongs to the cysteine synthase cystathionine beta- synthase family cysM GO:0000003,GO:0000096,GO:0000097,GO:0000902,GO:0000904,GO:0003006,GO:0003674,GO:0003824,GO:0004124,GO:0005488,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005773,GO:0005774,GO:0005777,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006790,GO:0006807,GO:0007568,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009507,GO:0009532,GO:0009536,GO:0009566,GO:0009567,GO:0009570,GO:0009653,GO:0009826,GO:0009856,GO:0009860,GO:0009932,GO:0009987,GO:0010035,GO:0010038,GO:0016020,GO:0016043,GO:0016049,GO:0016053,GO:0016740,GO:0016765,GO:0019344,GO:0019752,GO:0019842,GO:0019953,GO:0022414,GO:0030154,GO:0030170,GO:0031090,GO:0032501,GO:0032502,GO:0032989,GO:0036094,GO:0040007,GO:0042221,GO:0042579,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044437,GO:0044444,GO:0044446,GO:0044464,GO:0044703,GO:0044706,GO:0046394,GO:0046686,GO:0048037,GO:0048046,GO:0048468,GO:0048588,GO:0048589,GO:0048856,GO:0048868,GO:0048869,GO:0050662,GO:0050896,GO:0051704,GO:0060560,GO:0070279,GO:0071704,GO:0071840,GO:0071944,GO:0097159,GO:0098588,GO:0098805,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.5.1.47 ko:K12339 ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230 M00021 R00897,R03132,R03601,R04859 RC00020,RC02814,RC02821,RC02876 ko00000,ko00001,ko00002,ko01000 - - - PALP k59_1380681_2 522306.CAP2UW1_2894 4.25e-41 146.0 COG0451@1|root,COG0451@2|Bacteria,1MVE4@1224|Proteobacteria,2VH69@28216|Betaproteobacteria,1KQBQ@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria G Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose hldD - 5.1.3.20 ko:K03274 ko00540,ko01100,map00540,map01100 M00064 R05176 RC01291 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Epimerase k59_1042375_2 377629.TERTU_0232 7.25e-58 181.0 COG0745@1|root,COG0745@2|Bacteria,1RI9T@1224|Proteobacteria,1S5UT@1236|Gammaproteobacteria,2PNNP@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria KT Response regulator receiver domain pilH - - ko:K02658 ko02020,ko02025,map02020,map02025 M00507 - - ko00000,ko00001,ko00002,ko02022,ko02035,ko02044 - - - Response_reg k59_1042375_3 1415778.JQMM01000001_gene645 5.06e-50 161.0 COG0745@1|root,COG0745@2|Bacteria,1RDYB@1224|Proteobacteria,1S4CZ@1236|Gammaproteobacteria,1J60V@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T COG0784 FOG CheY-like receiver pilG - - ko:K02657,ko:K03413 ko02020,ko02025,ko02030,map02020,map02025,map02030 M00506,M00507 - - ko00000,ko00001,ko00002,ko02022,ko02035,ko02044 - - - Response_reg k59_813920_1 2074.JNYD01000005_gene3018 1.27e-46 162.0 COG2267@1|root,COG2267@2|Bacteria,2I2KD@201174|Actinobacteria,4EF63@85010|Pseudonocardiales 201174|Actinobacteria I Alpha/beta hydrolase family ephA GO:0000287,GO:0001676,GO:0002532,GO:0002538,GO:0002539,GO:0003008,GO:0003013,GO:0003674,GO:0003824,GO:0004301,GO:0005102,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005777,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006725,GO:0006793,GO:0006796,GO:0006950,GO:0006952,GO:0006954,GO:0007600,GO:0008015,GO:0008150,GO:0008152,GO:0008217,GO:0009056,GO:0009810,GO:0009893,GO:0009987,GO:0010468,GO:0010604,GO:0010628,GO:0015643,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0016801,GO:0016803,GO:0018742,GO:0018904,GO:0019216,GO:0019218,GO:0019222,GO:0019233,GO:0019439,GO:0019752,GO:0030258,GO:0032501,GO:0032787,GO:0033559,GO:0042577,GO:0042578,GO:0042579,GO:0042592,GO:0042632,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0043651,GO:0044237,GO:0044238,GO:0044248,GO:0044255,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045777,GO:0046272,GO:0046483,GO:0046839,GO:0046872,GO:0046983,GO:0048518,GO:0048878,GO:0050789,GO:0050877,GO:0050896,GO:0055088,GO:0055092,GO:0060255,GO:0062012,GO:0065007,GO:0065008,GO:0071704,GO:0080090,GO:0090181,GO:0097176,GO:1900673,GO:1901360,GO:1901361,GO:1901575 - - - - - - - - - - Abhydrolase_1,Abhydrolase_6 k59_1493953_1 1249627.D779_3018 4.69e-41 141.0 COG1051@1|root,COG1051@2|Bacteria,1REBW@1224|Proteobacteria,1S3XB@1236|Gammaproteobacteria,1WYGA@135613|Chromatiales 135613|Chromatiales F Nudix N-terminal - - - - - - - - - - - - NUDIX,Nudix_N_2 k59_1380689_1 395493.BegalDRAFT_1750 9.5e-64 221.0 COG1305@1|root,COG4196@1|root,COG1305@2|Bacteria,COG4196@2|Bacteria,1MVAG@1224|Proteobacteria,1RMX2@1236|Gammaproteobacteria,461RZ@72273|Thiotrichales 72273|Thiotrichales E Putative amidoligase enzyme (DUF2126) - - - - - - - - - - - - Bact_transglu_N,DUF2126,Transglut_core k59_1153560_1 1177154.Y5S_02570 6.49e-78 244.0 COG0389@1|root,COG0389@2|Bacteria,1MUUH@1224|Proteobacteria,1RMT1@1236|Gammaproteobacteria,1XH3E@135619|Oceanospirillales 135619|Oceanospirillales L DNA polymerase umuC - - ko:K03502 - - - - ko00000,ko03400 - - - DUF4113,IMS,IMS_C,IMS_HHH k59_1550282_1 1120999.JONM01000001_gene1212 2.69e-32 124.0 COG3386@1|root,COG3386@2|Bacteria,1MWTR@1224|Proteobacteria,2VK84@28216|Betaproteobacteria 28216|Betaproteobacteria G PFAM SMP-30 Gluconolaconase - - 3.1.1.15 ko:K13874 ko00053,ko01100,map00053,map01100 - R02526 RC00537 ko00000,ko00001,ko01000 - - - SGL k59_192939_1 1380358.JADJ01000015_gene2301 1.27e-70 221.0 COG0325@1|root,COG0325@2|Bacteria,1MWN7@1224|Proteobacteria,1RNPM@1236|Gammaproteobacteria,1XJ5Q@135619|Oceanospirillales 135619|Oceanospirillales S Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis - - - ko:K06997 - - - - ko00000 - - - Ala_racemase_N k59_192939_2 1123228.AUIH01000034_gene2773 3.18e-25 103.0 COG0345@1|root,COG0345@2|Bacteria,1R5J1@1224|Proteobacteria,1RNQK@1236|Gammaproteobacteria,1XI4M@135619|Oceanospirillales 135619|Oceanospirillales E Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline proC - 1.5.1.2 ko:K00286 ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230 M00015 R01248,R01251,R03291,R03293 RC00054,RC00083 ko00000,ko00001,ko00002,ko01000 - - - F420_oxidored,P5CR_dimer k59_872657_1 177437.HRM2_17460 3.45e-28 122.0 COG2199@1|root,COG3706@2|Bacteria,1RGSE@1224|Proteobacteria,42S8P@68525|delta/epsilon subdivisions,2WNZ9@28221|Deltaproteobacteria,2MJYC@213118|Desulfobacterales 28221|Deltaproteobacteria T diguanylate cyclase - - 2.7.7.65 ko:K02488 ko02020,ko04112,map02020,map04112 M00511 R08057 - ko00000,ko00001,ko00002,ko01000,ko02022 - - - GGDEF,PAS_9,Response_reg k59_1435050_2 691883.XP_009495288.1 6.49e-71 232.0 COG1760@1|root,2QVSV@2759|Eukaryota,39R6I@33154|Opisthokonta 33154|Opisthokonta E Serine dehydratase beta chain - - - - - - - - - - - - SDH_alpha,SDH_beta k59_419298_1 379731.PST_0022 2.2e-41 148.0 COG1652@1|root,COG1652@2|Bacteria,1MUBV@1224|Proteobacteria,1RPMB@1236|Gammaproteobacteria,1YZTS@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria S protein containing LysM domain lysM - - - - - - - - - - - LysM k59_1096495_1 314287.GB2207_04532 3.89e-93 280.0 COG0681@1|root,COG0681@2|Bacteria,1MXUF@1224|Proteobacteria,1RMHI@1236|Gammaproteobacteria,1J5QR@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria U Belongs to the peptidase S26 family lepB GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 3.4.21.89 ko:K03100 ko02024,ko03060,map02024,map03060 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_S24,Peptidase_S26 k59_474686_1 1280948.HY36_13280 4.74e-21 89.4 2E5P2@1|root,330DQ@2|Bacteria,1NEA8@1224|Proteobacteria,2VE4N@28211|Alphaproteobacteria,43ZYJ@69657|Hyphomonadaceae 28211|Alphaproteobacteria S MAPEG family - - - - - - - - - - - - MAPEG k59_474686_2 395495.Lcho_3854 4.06e-21 90.9 COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,2VH4C@28216|Betaproteobacteria,1KITF@119065|unclassified Burkholderiales 28216|Betaproteobacteria I Belongs to the thiolase family bktB - 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N k59_192947_1 436308.Nmar_0877 4.39e-55 173.0 COG0640@1|root,arCOG03067@2157|Archaea,41T4C@651137|Thaumarchaeota 651137|Thaumarchaeota K transcriptional regulators - - - - - - - - - - - - HTH_20 k59_137445_1 759362.KVU_0133 1.99e-38 139.0 COG0009@1|root,COG0009@2|Bacteria,1MVPM@1224|Proteobacteria,2TRIM@28211|Alphaproteobacteria 28211|Alphaproteobacteria J Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine - GO:0000049,GO:0000166,GO:0002949,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006450,GO:0006725,GO:0006807,GO:0008033,GO:0008144,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034470,GO:0034641,GO:0034660,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0065007,GO:0065008,GO:0070525,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901363 2.7.7.87 ko:K07566 - - R10463 RC00745 ko00000,ko01000,ko03009,ko03016 - - - SUA5,Sua5_yciO_yrdC k59_137445_2 37682.EMT04309 2.89e-14 74.3 COG0277@1|root,KOG1232@2759|Eukaryota,37IKT@33090|Viridiplantae,3GFK4@35493|Streptophyta,3KV0U@4447|Liliopsida,3I9RK@38820|Poales 35493|Streptophyta C FAD linked oxidases, C-terminal domain D2HGDH GO:0000166,GO:0003674,GO:0003824,GO:0004457,GO:0004458,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0006082,GO:0006089,GO:0006091,GO:0006807,GO:0008150,GO:0008152,GO:0009853,GO:0009987,GO:0015980,GO:0016491,GO:0016614,GO:0016898,GO:0019516,GO:0019752,GO:0022900,GO:0022904,GO:0032787,GO:0036094,GO:0043094,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0047545,GO:0048037,GO:0050660,GO:0050662,GO:0051990,GO:0055114,GO:0071704,GO:0071949,GO:0097159,GO:1901265,GO:1901363,GO:1901615 1.1.99.39 ko:K18204 - - - - ko00000,ko01000 - - - FAD-oxidase_C,FAD_binding_4 k59_982481_1 1122599.AUGR01000015_gene2653 5.24e-35 130.0 COG0560@1|root,COG0560@2|Bacteria,1MWA3@1224|Proteobacteria,1RNJE@1236|Gammaproteobacteria,1XIJX@135619|Oceanospirillales 135619|Oceanospirillales E phosphoserine phosphatase serB - 3.1.3.3 ko:K01079 ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230 M00020 R00582 RC00017 ko00000,ko00001,ko00002,ko01000,ko01009 - - - ACT_6,HAD k59_982481_2 1123024.AUII01000033_gene1401 1.04e-40 142.0 COG0596@1|root,COG0596@2|Bacteria,2IAKH@201174|Actinobacteria,4E9MU@85010|Pseudonocardiales 201174|Actinobacteria S Alpha/beta hydrolase family - - - - - - - - - - - - Abhydrolase_1,Abhydrolase_6 k59_419303_1 543728.Vapar_2879 1.16e-15 77.8 COG1063@1|root,COG1063@2|Bacteria,1MV9A@1224|Proteobacteria,2VMPR@28216|Betaproteobacteria,4AADS@80864|Comamonadaceae 28216|Betaproteobacteria C Alcohol dehydrogenase zinc-binding domain protein idnD - 1.1.1.264 ko:K00098 - - R05684 RC00089 ko00000,ko01000 - - - ADH_N,ADH_zinc_N k59_419303_2 1411685.U062_01204 1.68e-05 48.9 COG2015@1|root,COG2015@2|Bacteria,1MU82@1224|Proteobacteria,1S468@1236|Gammaproteobacteria,1J8U1@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria Q Alkyl sulfatase dimerisation - - - - - - - - - - - - Alkyl_sulf_dimr,Lactamase_B k59_1719195_1 402881.Plav_3081 5.24e-27 111.0 COG1197@1|root,COG1197@2|Bacteria,1MUXG@1224|Proteobacteria,2TR2H@28211|Alphaproteobacteria,1JN56@119043|Rhodobiaceae 28211|Alphaproteobacteria L Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site mfd - - ko:K03723 ko03420,map03420 - - - ko00000,ko00001,ko01000,ko03400 - - - CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF k59_1719195_2 1122137.AQXF01000006_gene869 4.2e-31 110.0 COG2938@1|root,COG2938@2|Bacteria 2|Bacteria C An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH sdhE GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006105,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016043,GO:0016999,GO:0017013,GO:0017144,GO:0018065,GO:0018293,GO:0019538,GO:0019752,GO:0022607,GO:0034552,GO:0034622,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0043648,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044281,GO:0045333,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:0072350,GO:1901564 1.3.5.1,1.3.5.4 ko:K00240,ko:K09159 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00149,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002,ko01000,ko02048 - - - Sdh5 k59_589013_1 1279017.AQYJ01000027_gene1876 1.19e-67 219.0 COG1301@1|root,COG1301@2|Bacteria,1MU0Q@1224|Proteobacteria,1RMEN@1236|Gammaproteobacteria,463Y3@72275|Alteromonadaceae 1236|Gammaproteobacteria U Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family gltT - - ko:K03309 - - - - ko00000 2.A.23 - - SDF k59_81870_1 298655.KI912266_gene4726 6.49e-128 378.0 COG1012@1|root,COG1012@2|Bacteria 2|Bacteria C belongs to the aldehyde dehydrogenase family luxC - 1.2.1.50 ko:K03400 ko02020,ko02024,map02020,map02024 - R10549 RC00004,RC00184 ko00000,ko00001,ko01000 - - - LuxC k59_1435067_1 290398.Csal_0779 6.56e-64 209.0 COG1757@1|root,COG1757@2|Bacteria,1MY5C@1224|Proteobacteria,1RP6I@1236|Gammaproteobacteria,1XHCS@135619|Oceanospirillales 135619|Oceanospirillales C sodium proton antiporter - - - - - - - - - - - - Na_H_antiporter k59_1096509_1 1340493.JNIF01000003_gene3040 3.37e-53 172.0 COG3293@1|root,COG3293@2|Bacteria,3Y7X8@57723|Acidobacteria 57723|Acidobacteria L Transposase DDE domain - - - - - - - - - - - - DDE_Tnp_1,DDE_Tnp_1_2 k59_872704_1 436308.Nmar_1227 6.82e-33 118.0 COG1310@1|root,arCOG01138@2157|Archaea,41SSV@651137|Thaumarchaeota 651137|Thaumarchaeota S metal-dependent protease of the PAD1 JAB1 superfamily - - 3.13.1.6 ko:K21140 ko04122,map04122 - R11524 RC00064,RC00090 ko00000,ko00001,ko01000 - - - Prok-JAB k59_872704_2 436308.Nmar_0185 2.28e-17 81.3 COG3794@1|root,arCOG03700@1|root,arCOG02926@2157|Archaea,arCOG03700@2157|Archaea 2157|Archaea C Blue copper protein - - - - - - - - - - - - Copper-bind k59_1322628_1 702113.PP1Y_AT20520 4.76e-90 269.0 COG0593@1|root,COG0593@2|Bacteria,1N4PG@1224|Proteobacteria,2U96K@28211|Alphaproteobacteria,2K4AT@204457|Sphingomonadales 204457|Sphingomonadales L ATPase involved in DNA replication - - - - - - - - - - - - Bac_DnaA k59_872707_1 379066.GAU_3550 9.79e-12 65.5 COG0591@1|root,COG0591@2|Bacteria 2|Bacteria E symporter activity - - - ko:K03307 - - - - ko00000 2.A.21 - - SSF k59_872707_2 1382304.JNIL01000001_gene1240 2.13e-23 99.8 COG3191@1|root,COG3191@2|Bacteria,1TP60@1239|Firmicutes,4HD7F@91061|Bacilli,2794M@186823|Alicyclobacillaceae 91061|Bacilli EQ Peptidase family S58 - - - - - - - - - - - - Peptidase_S58 k59_757169_1 1042375.AFPL01000022_gene2492 4.95e-22 97.1 COG2976@1|root,COG2976@2|Bacteria,1N117@1224|Proteobacteria,1S95P@1236|Gammaproteobacteria,467Y0@72275|Alteromonadaceae 1236|Gammaproteobacteria S protein conserved in bacteria yfgM GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0009897,GO:0009986,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0031233,GO:0044425,GO:0044459,GO:0044464,GO:0071575,GO:0071944,GO:0098552 - - - - - - - - - - TPR_21 k59_757169_2 455436.DS989814_gene932 0.000233 46.2 COG1520@1|root,COG1520@2|Bacteria,1MXIJ@1224|Proteobacteria,1RN4V@1236|Gammaproteobacteria,4648Z@72275|Alteromonadaceae 1236|Gammaproteobacteria M Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane bamB GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0008104,GO:0008150,GO:0008152,GO:0009279,GO:0009987,GO:0016020,GO:0016043,GO:0016491,GO:0019867,GO:0022607,GO:0030312,GO:0030313,GO:0031224,GO:0031230,GO:0031241,GO:0031246,GO:0031975,GO:0032991,GO:0033036,GO:0034613,GO:0042802,GO:0043163,GO:0043165,GO:0044085,GO:0044091,GO:0044425,GO:0044462,GO:0044464,GO:0045184,GO:0045229,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0055114,GO:0061024,GO:0070727,GO:0071709,GO:0071840,GO:0071944,GO:0072657,GO:0090150,GO:0098552,GO:0098796,GO:1990063 - ko:K17713 - - - - ko00000,ko02000 1.B.33.1 - - PQQ_2,PQQ_3 k59_307500_1 1229909.NSED_01265 1.85e-184 524.0 COG0439@1|root,arCOG01590@2157|Archaea,41SXC@651137|Thaumarchaeota 651137|Thaumarchaeota I Carbamoyl-phosphate synthase L chain - - 6.4.1.2,6.4.1.3 ko:K18603 ko00720,ko01120,map00720,map01120 - R00742,R01859 RC00040,RC00097,RC00367,RC00609 ko00000,ko00001,ko01000 - - - Biotin_carb_C,Biotin_carb_N,CPSase_L_D2 k59_1265310_1 1122137.AQXF01000003_gene2261 3.59e-98 312.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2TQT0@28211|Alphaproteobacteria 28211|Alphaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_1210702_1 977880.RALTA_A2461 1.01e-214 608.0 COG0129@1|root,COG0129@2|Bacteria,1MUTQ@1224|Proteobacteria,2VH5Q@28216|Betaproteobacteria,1JZV8@119060|Burkholderiaceae 28216|Betaproteobacteria EG Belongs to the IlvD Edd family ilvD - 4.2.1.9 ko:K01687 ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R01209,R04441,R05070 RC00468,RC01714 ko00000,ko00001,ko00002,ko01000 - - - ILVD_EDD k59_1210702_2 1096930.L284_13770 6.48e-16 78.2 COG0457@1|root,COG3914@1|root,COG0457@2|Bacteria,COG3914@2|Bacteria,1MVMG@1224|Proteobacteria,2TRVB@28211|Alphaproteobacteria,2K1FV@204457|Sphingomonadales 204457|Sphingomonadales O Glycosyl transferase family 41 - - - - - - - - - - - - Glyco_transf_41,TPR_1,TPR_11,TPR_16,TPR_2,TPR_6,TPR_8 k59_982509_1 1121468.AUBR01000017_gene2375 6.58e-47 165.0 COG0065@1|root,COG0065@2|Bacteria,1TPE5@1239|Firmicutes,2484F@186801|Clostridia,42FQ2@68295|Thermoanaerobacterales 186801|Clostridia H Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate - - 4.2.1.33,4.2.1.35 ko:K01703 ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230 M00432,M00535 R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170 RC00497,RC00976,RC00977,RC01041,RC01046,RC03072 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase k59_1153610_1 1265313.HRUBRA_00195 3.94e-95 288.0 COG2262@1|root,COG2262@2|Bacteria,1MUA0@1224|Proteobacteria,1RN7V@1236|Gammaproteobacteria,1J4RK@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis hflX GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0003924,GO:0005488,GO:0005524,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006414,GO:0006417,GO:0006464,GO:0006468,GO:0006518,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006996,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010608,GO:0016043,GO:0016310,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0018105,GO:0018193,GO:0018209,GO:0019001,GO:0019222,GO:0019538,GO:0019843,GO:0022411,GO:0030554,GO:0031323,GO:0031326,GO:0032268,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032559,GO:0032561,GO:0032790,GO:0032984,GO:0032988,GO:0034248,GO:0034641,GO:0034645,GO:0035639,GO:0036094,GO:0036211,GO:0036289,GO:0043021,GO:0043022,GO:0043023,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043603,GO:0043604,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0046777,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051246,GO:0060255,GO:0065007,GO:0071704,GO:0071826,GO:0071840,GO:0072344,GO:0080090,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903008,GO:2000112 - ko:K03665 - - - - ko00000,ko03009 - - - GTP-bdg_M,GTP-bdg_N,MMR_HSR1 k59_1042442_2 1205680.CAKO01000010_gene3974 1.21e-105 314.0 COG1028@1|root,COG1028@2|Bacteria,1MUFX@1224|Proteobacteria,2TRWN@28211|Alphaproteobacteria 28211|Alphaproteobacteria IQ COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - - - - - - - - - - - adh_short_C2 k59_757176_1 1229909.NSED_04820 5.41e-49 170.0 COG0642@1|root,arCOG02362@1|root,arCOG02358@2157|Archaea,arCOG02362@2157|Archaea 2157|Archaea T Histidine kinase - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - CHASE4,HAMP,HATPase_c,HisKA,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg,dCache_1,sCache_3_3 k59_307510_1 85643.Tmz1t_0618 1.24e-60 200.0 COG2223@1|root,COG2223@2|Bacteria,1QVKP@1224|Proteobacteria,2WGTA@28216|Betaproteobacteria,2KZWK@206389|Rhodocyclales 206389|Rhodocyclales P Major facilitator superfamily - - - - - - - - - - - - MFS_1 k59_589053_1 1229909.NSED_00395 1.43e-170 487.0 COG0843@1|root,arCOG01237@2157|Archaea,41S9Z@651137|Thaumarchaeota 651137|Thaumarchaeota C Heme copper-type cytochrome quinol - - 1.9.3.1 ko:K02274 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6 - - COX1 k59_137498_1 246200.SPOA0309 1.06e-44 162.0 COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,2TSTW@28211|Alphaproteobacteria,4ND47@97050|Ruegeria 28211|Alphaproteobacteria EH Thiamine pyrophosphate enzyme, central domain - - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_419337_1 1280949.HAD_07565 9.07e-25 102.0 COG3803@1|root,COG3803@2|Bacteria,1RHYI@1224|Proteobacteria,2U7AN@28211|Alphaproteobacteria,43XSR@69657|Hyphomonadaceae 28211|Alphaproteobacteria S Bacterial protein of unknown function (DUF924) - - - - - - - - - - - - DUF924 k59_474726_1 1206737.BAGF01000023_gene1168 5.26e-51 180.0 COG2124@1|root,COG2124@2|Bacteria,2GJ8V@201174|Actinobacteria,4FVFD@85025|Nocardiaceae 201174|Actinobacteria Q Cytochrome P450 - - - - - - - - - - - - p450 k59_531277_1 313598.MED152_01545 6.92e-62 205.0 COG0006@1|root,COG0006@2|Bacteria,4NI0S@976|Bacteroidetes,1HZX1@117743|Flavobacteriia,3VVA3@52959|Polaribacter 976|Bacteroidetes E Aminopeptidase P, N-terminal domain - - 3.4.11.9 ko:K01262 - - - - ko00000,ko01000,ko01002 - - - AMP_N,Peptidase_M24 k59_531277_2 1121007.AUML01000002_gene1695 6.64e-07 52.4 COG3211@1|root,COG3211@2|Bacteria,4NFM3@976|Bacteroidetes,1HYI3@117743|Flavobacteriia,2YHNV@290174|Aquimarina 976|Bacteroidetes S Phosphatase - - - - - - - - - - - - - k59_308866_1 1207063.P24_09696 9.4e-62 204.0 COG2379@1|root,COG2379@2|Bacteria,1MVIK@1224|Proteobacteria,2TQJY@28211|Alphaproteobacteria,2JQ50@204441|Rhodospirillales 204441|Rhodospirillales G Domain of unknown function (DUF4147) ttuD - 2.7.1.165 ko:K11529 ko00030,ko00260,ko00561,ko00630,ko00680,ko01100,ko01120,ko01130,ko01200,map00030,map00260,map00561,map00630,map00680,map01100,map01120,map01130,map01200 M00346 R08572 RC00002,RC00428 ko00000,ko00001,ko00002,ko01000 - - - DUF4147,MOFRL k59_703639_1 572477.Alvin_1049 6.46e-56 186.0 COG5345@1|root,COG5345@2|Bacteria,1MWVH@1224|Proteobacteria,1RP5X@1236|Gammaproteobacteria,1WVX3@135613|Chromatiales 135613|Chromatiales S PFAM Uncharacterised conserved protein UCP029693 - - - - - - - - - - - - DUF2333 k59_1154663_1 1449076.JOOE01000004_gene74 2.88e-43 158.0 COG0793@1|root,COG0793@2|Bacteria,1MUA3@1224|Proteobacteria,2U1FI@28211|Alphaproteobacteria,2K0WR@204457|Sphingomonadales 204457|Sphingomonadales M Peptidase family S41 - - - - - - - - - - - - Peptidase_S41 k59_874034_1 1298863.AUEP01000007_gene397 3.65e-27 115.0 COG2211@1|root,COG2211@2|Bacteria,2HD4Y@201174|Actinobacteria,4DP2D@85009|Propionibacteriales 201174|Actinobacteria G MFS/sugar transport protein - - - ko:K03292 - - - - ko00000 2.A.2 - - MFS_2 k59_1266489_1 713587.THITH_07930 6.73e-90 287.0 COG0188@1|root,COG0188@2|Bacteria,1MUGG@1224|Proteobacteria,1RN03@1236|Gammaproteobacteria,1WXK8@135613|Chromatiales 135613|Chromatiales L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrA - 5.99.1.3 ko:K02469 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseA_C,DNA_topoisoIV k59_1323592_1 1207058.L53_04075 1.73e-18 85.9 28JQH@1|root,2Z9GD@2|Bacteria,1R2MF@1224|Proteobacteria,2TZS1@28211|Alphaproteobacteria,44163@69657|Hyphomonadaceae 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_1551901_1 1122137.AQXF01000002_gene530 1.62e-67 221.0 COG1574@1|root,COG1574@2|Bacteria,1MWP2@1224|Proteobacteria,2TTRU@28211|Alphaproteobacteria 28211|Alphaproteobacteria K metal-dependent hydrolase with the TIM-barrel fold - - - - - - - - - - - - Amidohydro_3 k59_1551901_2 1122137.AQXF01000002_gene529 4.26e-48 154.0 COG1522@1|root,COG1522@2|Bacteria 2|Bacteria K sequence-specific DNA binding QU41_18010 - 2.4.2.18 ko:K00766,ko:K03719 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R01073 RC00440 ko00000,ko00001,ko00002,ko01000,ko03000,ko03036 - - - AsnC_trans_reg k59_1551901_3 876269.ARWA01000001_gene2004 4.43e-62 208.0 COG1233@1|root,COG1233@2|Bacteria,1MV2R@1224|Proteobacteria,2TSR0@28211|Alphaproteobacteria,3NCSI@45404|Beijerinckiaceae 28211|Alphaproteobacteria Q Flavin containing amine oxidoreductase MA20_01895 - 1.3.99.27 ko:K09845 ko00906,ko01100,map00906,map01100 - R07517,R07520,R07523,R07534 RC02080 ko00000,ko00001,ko01000 - - - Amino_oxidase k59_703667_1 330214.NIDE1738 4.23e-36 133.0 COG1893@1|root,COG2041@1|root,COG1893@2|Bacteria,COG2041@2|Bacteria,3J0S5@40117|Nitrospirae 40117|Nitrospirae H Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid - - 1.1.1.169 ko:K00077 ko00770,ko01100,ko01110,map00770,map01100,map01110 M00119 R02472 RC00726 ko00000,ko00001,ko00002,ko01000 - - - ApbA,ApbA_C k59_703667_2 330214.NIDE1739 2.4e-45 158.0 COG0534@1|root,COG0534@2|Bacteria 2|Bacteria V drug transmembrane transporter activity norM - - ko:K03327 - - - - ko00000,ko02000 2.A.66.1 - - MatE k59_874060_1 1122137.AQXF01000001_gene3150 4.74e-160 474.0 COG1049@1|root,COG1049@2|Bacteria,1MVCR@1224|Proteobacteria,2TS9P@28211|Alphaproteobacteria 28211|Alphaproteobacteria C aconitate hydratase acnB - 4.2.1.3,4.2.1.99 ko:K01682 ko00020,ko00630,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00173 R01324,R01325,R01900,R04425 RC00497,RC00498,RC00618,RC01153 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase,Aconitase_2_N,Aconitase_B_N k59_874060_2 46429.BV95_02816 8.96e-16 82.4 COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TR8X@28211|Alphaproteobacteria,2K0ZS@204457|Sphingomonadales 204457|Sphingomonadales T nitrogen fixation sensor protein fixL - - 2.7.13.3 ko:K14986 ko02020,map02020 M00524 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - DUF4118,HATPase_c,HisKA,PAS,PAS_9 k59_83283_1 1121381.JNIV01000024_gene1474 1.64e-08 55.5 COG1089@1|root,COG1089@2|Bacteria,1WJ99@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus M Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose gmd - 4.2.1.47 ko:K01711 ko00051,ko00520,ko01100,map00051,map00520,map01100 - R00888 RC00402 ko00000,ko00001,ko01000 - - - GDP_Man_Dehyd k59_83283_2 517418.Ctha_2066 7.07e-67 212.0 COG0451@1|root,COG0451@2|Bacteria,1FETF@1090|Chlorobi 1090|Chlorobi C Catalyzes the two-step NADP-dependent conversion of GDP- 4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction fcl - 1.1.1.271 ko:K02377 ko00051,ko00520,ko01100,map00051,map00520,map01100 - R05692 RC01014 ko00000,ko00001,ko01000 - - - Epimerase k59_1043832_1 498211.CJA_1648 2.75e-14 72.8 COG1026@1|root,COG1026@2|Bacteria,1MVDJ@1224|Proteobacteria,1RYNI@1236|Gammaproteobacteria,1FGZJ@10|Cellvibrio 1236|Gammaproteobacteria S Peptidase M16C associated - - - ko:K06972 - - - - ko00000,ko01000,ko01002 - - - M16C_assoc,Peptidase_M16,Peptidase_M16_C k59_1043832_2 1238450.VIBNISOn1_1540005 4.04e-21 94.0 COG0642@1|root,COG0642@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,1SKTW@1236|Gammaproteobacteria,1XTMV@135623|Vibrionales 1236|Gammaproteobacteria T Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - - - - - - - - - - CHASE3,GAF_2,HAMP,HATPase_c,HisKA,Hpt,PAS_4,PAS_9,Response_reg k59_814828_2 1000565.METUNv1_02092 4.31e-124 362.0 COG1845@1|root,COG1845@2|Bacteria,1MUCK@1224|Proteobacteria,2VJAP@28216|Betaproteobacteria,2KVIW@206389|Rhodocyclales 206389|Rhodocyclales C COG1845 Heme copper-type cytochrome quinol oxidase, subunit 3 - - 1.9.3.1 ko:K02276 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.4,3.D.4.6 - - COX3 k59_590430_1 1408422.JHYF01000009_gene1958 7.02e-12 69.7 28PHB@1|root,2ZC7V@2|Bacteria,1V1MY@1239|Firmicutes,24H5K@186801|Clostridia,36IHD@31979|Clostridiaceae 186801|Clostridia - - - - - - - - - - - - - - - k59_814830_1 316407.85676282 2.23e-130 374.0 COG0583@1|root,COG0583@2|Bacteria,1MXXA@1224|Proteobacteria,1RREE@1236|Gammaproteobacteria,3XMXC@561|Escherichia 1236|Gammaproteobacteria K Negatively regulates the transcription of the flagellar master operon flhDC by binding to the upstream region of the operon hdfR GO:0003674,GO:0003700,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0140110,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 - - - - - - - - - - HTH_1,LysR_substrate k59_1266527_1 1380387.JADM01000002_gene2301 9.75e-06 46.6 COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,1RNB5@1236|Gammaproteobacteria,1XHZR@135619|Oceanospirillales 135619|Oceanospirillales C L-carnitine dehydratase bile acid-inducible protein F - - - - - - - - - - - - CoA_transf_3 k59_1266527_2 96561.Dole_1604 1.82e-27 111.0 COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,42MK5@68525|delta/epsilon subdivisions 1224|Proteobacteria C acyl-coa dehydrogenase caiA GO:0003674,GO:0003824,GO:0006066,GO:0008150,GO:0008152,GO:0009058,GO:0016491,GO:0016627,GO:0034308,GO:0034309,GO:0044281,GO:0044283,GO:0046165,GO:0052890,GO:0055114,GO:0071270,GO:0071271,GO:0071704,GO:1901576,GO:1901615,GO:1901617 1.3.8.13 ko:K08297 - - - - ko00000,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_703700_1 1122599.AUGR01000012_gene901 8.97e-109 319.0 arCOG03638@1|root,2Z7NN@2|Bacteria,1R3Y6@1224|Proteobacteria,1RTWY@1236|Gammaproteobacteria,1XIZW@135619|Oceanospirillales 135619|Oceanospirillales S Protein of unknown function (DUF1538) - - - - - - - - - - - - DUF1538 k59_1720677_1 679197.HMPREF9336_01959 4.06e-65 222.0 COG4770@1|root,COG4770@2|Bacteria,2GIZP@201174|Actinobacteria 201174|Actinobacteria I carboxylase accBC - 6.3.4.14,6.4.1.2,6.4.1.3 ko:K11263 ko00061,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00741 R00742,R01859,R04385 RC00040,RC00097,RC00253,RC00367,RC00609 ko00000,ko00001,ko00002,ko01000 - - iNJ661.Rv3285 Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2 k59_1720677_2 997346.HMPREF9374_0342 1.17e-140 417.0 COG1884@1|root,COG1884@2|Bacteria,1TQAD@1239|Firmicutes,4H9QB@91061|Bacilli,27B33@186824|Thermoactinomycetaceae 91061|Bacilli I Methylmalonyl-CoA mutase - - 5.4.99.2 ko:K01848 ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200 M00375,M00376,M00741 R00833 RC00395 ko00000,ko00001,ko00002,ko01000 - - - MM_CoA_mutase k59_1097664_1 702113.PP1Y_AT11631 1.6e-36 130.0 2BNU4@1|root,32HHX@2|Bacteria,1NQV4@1224|Proteobacteria,2VD3V@28211|Alphaproteobacteria,2K9PS@204457|Sphingomonadales 204457|Sphingomonadales - - - - - - - - - - - - - - - k59_1097664_2 627192.SLG_12660 3.67e-30 114.0 COG4922@1|root,COG4922@2|Bacteria,1RDM5@1224|Proteobacteria,2UG54@28211|Alphaproteobacteria,2K5PK@204457|Sphingomonadales 204457|Sphingomonadales S SnoaL-like polyketide cyclase - - - - - - - - - - - - SnoaL_2 k59_1720679_1 472759.Nhal_3450 1.81e-43 157.0 COG0021@1|root,COG0021@2|Bacteria,1MUEY@1224|Proteobacteria,1RMWP@1236|Gammaproteobacteria,1WVWH@135613|Chromatiales 135613|Chromatiales G Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate - - 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 - - - Transket_pyr,Transketolase_C,Transketolase_N k59_1720679_2 998088.B565_0759 4.99e-11 62.0 COG0057@1|root,COG0057@2|Bacteria,1MU93@1224|Proteobacteria,1RMBM@1236|Gammaproteobacteria,1Y45S@135624|Aeromonadales 135624|Aeromonadales H Catalyzes the NAD-dependent conversion of D-erythrose 4- phosphate to 4-phosphoerythronate epd - 1.2.1.72 ko:K03472 ko00750,ko01100,map00750,map01100 M00124 R01825 RC00242 ko00000,ko00001,ko00002,ko01000 - - - Gp_dh_C,Gp_dh_N k59_1154712_1 1144310.PMI07_002397 7.05e-22 91.7 COG1430@1|root,COG1430@2|Bacteria,1MZBJ@1224|Proteobacteria,2UBSI@28211|Alphaproteobacteria,4BFDI@82115|Rhizobiaceae 28211|Alphaproteobacteria S Uncharacterized ACR, COG1430 - - - ko:K09005 - - - - ko00000 - - - DUF192 k59_1495512_1 511145.b2964 5.4e-96 290.0 COG2211@1|root,COG2211@2|Bacteria,1MWI9@1224|Proteobacteria,1RMU5@1236|Gammaproteobacteria,3XNB0@561|Escherichia 1236|Gammaproteobacteria G Broad-specificity transporter of purine and pyrimidine nucleosides. Driven by a proton motive force nupG GO:0003674,GO:0005215,GO:0005337,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006139,GO:0006725,GO:0006807,GO:0006810,GO:0008150,GO:0008152,GO:0009987,GO:0015211,GO:0015212,GO:0015213,GO:0015214,GO:0015553,GO:0015858,GO:0015860,GO:0015861,GO:0015862,GO:0015863,GO:0015864,GO:0015893,GO:0015931,GO:0015932,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0032238,GO:0034641,GO:0042221,GO:0042493,GO:0044237,GO:0044238,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0046483,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071702,GO:0071704,GO:0071705,GO:0071944,GO:0072530,GO:0072531,GO:1901264,GO:1901360,GO:1901505,GO:1901642 - ko:K03289,ko:K11537 - - - - ko00000,ko02000 2.A.1.10.1,2.A.1.10.2 - iECS88_1305.ECS88_2595,iEcSMS35_1347.EcSMS35_3108 Nuc_H_symport k59_1562234_1 641526.ADIWIN_2666 1.1e-108 324.0 COG0006@1|root,COG0006@2|Bacteria,4NG40@976|Bacteroidetes,1HZDM@117743|Flavobacteriia 976|Bacteroidetes E aminopeptidase pepP - 3.4.11.9 ko:K01262 - - - - ko00000,ko01000,ko01002 - - - AMP_N,Peptidase_M24 k59_1728263_1 1122137.AQXF01000006_gene882 2.53e-116 358.0 COG1256@1|root,COG1256@2|Bacteria,1MV2M@1224|Proteobacteria,2TV1B@28211|Alphaproteobacteria 28211|Alphaproteobacteria N flagellar hook-associated protein flgK - - ko:K02396 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - Flg_bb_rod,Flg_bbr_C k59_1443264_1 436308.Nmar_0467 4.74e-93 286.0 arCOG08733@1|root,arCOG08733@2157|Archaea,41SRN@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1273427_1 1122137.AQXF01000002_gene63 5e-115 340.0 COG0112@1|root,COG0112@2|Bacteria,1MUIS@1224|Proteobacteria,2TQKT@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism glyA - 2.1.2.1 ko:K00600 ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523 M00140,M00141,M00346,M00532 R00945,R09099 RC00022,RC00112,RC01583,RC02958 ko00000,ko00001,ko00002,ko01000 - - - SHMT k59_1780568_1 316407.85674762 1.08e-29 116.0 COG0556@1|root,COG0556@2|Bacteria,1MUFK@1224|Proteobacteria,1RN6Z@1236|Gammaproteobacteria,3XMDY@561|Escherichia 1236|Gammaproteobacteria L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage uvrB GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009314,GO:0009380,GO:0009628,GO:0032991,GO:0042802,GO:0044424,GO:0044464,GO:0050896,GO:1902494,GO:1905347,GO:1905348,GO:1990391 - ko:K03702 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - Helicase_C,ResIII,UVR,UvrB k59_1780568_2 316407.85674761 4.06e-52 169.0 COG0132@1|root,COG0132@2|Bacteria,1RDRK@1224|Proteobacteria,1RSHS@1236|Gammaproteobacteria,3XNCC@561|Escherichia 1236|Gammaproteobacteria H Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring bioD GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004141,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016882,GO:0017076,GO:0017144,GO:0018130,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0034641,GO:0035639,GO:0036094,GO:0042364,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046872,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.3.3.3 ko:K01935 ko00780,ko01100,map00780,map01100 M00123,M00573,M00577 R03182 RC00868 ko00000,ko00001,ko00002,ko01000 - - iEC55989_1330.EC55989_0821,iECIAI1_1343.ECIAI1_0813,iECO103_1326.ECO103_0813,iECO111_1330.ECO111_0839,iECO26_1355.ECO26_0904,iECSE_1348.ECSE_0831,iECW_1372.ECW_m0833,iEKO11_1354.EKO11_3108,iEcE24377_1341.EcE24377A_0841,iSFV_1184.SFV_0761,iSSON_1240.SSON_0757,iWFL_1372.ECW_m0833,ic_1306.c0858 AAA_26 k59_482477_3 711393.AYRX01000095_gene3561 1.96e-114 354.0 COG1372@1|root,COG4695@1|root,COG1372@2|Bacteria,COG4695@2|Bacteria 2|Bacteria N Portal protein gp34 - 6.5.1.3 ko:K14415 - - - - ko00000,ko01000,ko03016 - - - Phage_portal k59_482477_4 398578.Daci_3437 3.37e-22 102.0 COG0740@1|root,COG0740@2|Bacteria,1MUQ9@1224|Proteobacteria,2VUAR@28216|Betaproteobacteria 28216|Betaproteobacteria OU Belongs to the peptidase S14 family - - - - - - - - - - - - CLP_protease k59_482477_5 479433.Caci_2852 3.55e-68 227.0 COG4653@1|root,COG4653@2|Bacteria 2|Bacteria G Phage capsid family - - - - - - - - - - - - Phage_capsid k59_91597_1 420324.KI912020_gene7588 4.66e-46 170.0 COG0642@1|root,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,2TQU3@28211|Alphaproteobacteria,1JQZH@119045|Methylobacteriaceae 28211|Alphaproteobacteria T PFAM ATP-binding region ATPase domain protein pdhS - - - - - - - - - - - HATPase_c,HisKA,PAS,PAS_4,PAS_8,PAS_9 k59_1562240_1 697282.Mettu_3503 5.42e-48 170.0 COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,1RN5K@1236|Gammaproteobacteria,1XERP@135618|Methylococcales 135618|Methylococcales MU outer membrane efflux - - - - - - - - - - - - OEP k59_91609_1 1122137.AQXF01000001_gene2972 1.22e-108 317.0 COG0745@1|root,COG0745@2|Bacteria,1MVCB@1224|Proteobacteria,2TR43@28211|Alphaproteobacteria 28211|Alphaproteobacteria T COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain chvI GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0006355,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032991,GO:0032993,GO:0043565,GO:0044212,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2001141 - ko:K14981 ko02020,map02020 M00520 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Trans_reg_C k59_537658_1 287.DR97_1187 3.74e-90 274.0 COG0372@1|root,COG0372@2|Bacteria,1MUKX@1224|Proteobacteria,1RNT1@1236|Gammaproteobacteria,1YE7A@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria C Citrate synthase, C-terminal domain prpC GO:0003674,GO:0003824,GO:0004108,GO:0006082,GO:0006091,GO:0006113,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0009987,GO:0015980,GO:0016740,GO:0016746,GO:0016829,GO:0016830,GO:0016833,GO:0016999,GO:0017144,GO:0019541,GO:0019679,GO:0019752,GO:0032787,GO:0036440,GO:0043436,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0046459,GO:0046912,GO:0050440,GO:0055114,GO:0071704 2.3.3.5 ko:K01659 ko00640,map00640 - R00931 RC00004,RC00406,RC02827 ko00000,ko00001,ko01000 - - iECED1_1282.ECED1_0365,iECIAI1_1343.ECIAI1_0334,iECIAI39_1322.ECIAI39_0347,iECP_1309.ECP_0408,iECSF_1327.ECSF_0308,iEcE24377_1341.EcE24377A_0357,iJN746.PP_2335,iLF82_1304.LF82_1740,iNRG857_1313.NRG857_01630 Citrate_synt k59_318798_1 1280953.HOC_18484 4.9e-11 62.0 COG1028@1|root,COG1028@2|Bacteria,1MX30@1224|Proteobacteria,2TR09@28211|Alphaproteobacteria 28211|Alphaproteobacteria IQ COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) linC - - - - - - - - - - - adh_short_C2 k59_318798_2 373994.Riv7116_4828 2.83e-65 210.0 COG0604@1|root,COG0604@2|Bacteria,1G4D5@1117|Cyanobacteria 1117|Cyanobacteria C PFAM Alcohol dehydrogenase GroES-like domain - - 1.6.5.5 ko:K00344 - - - - ko00000,ko01000 - - - ADH_N,ADH_zinc_N k59_482494_1 1449049.JONW01000005_gene1437 1.28e-07 52.8 COG0711@1|root,COG0711@2|Bacteria,1MZGU@1224|Proteobacteria,2UBVW@28211|Alphaproteobacteria,2KGUT@204458|Caulobacterales 204458|Caulobacterales C Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) - - - ko:K02109 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt_B k59_482494_2 1122137.AQXF01000005_gene1089 2.57e-24 92.8 COG0636@1|root,COG0636@2|Bacteria,1MZBU@1224|Proteobacteria,2UFPN@28211|Alphaproteobacteria 28211|Alphaproteobacteria C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation atpE - - ko:K02110 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt_C k59_934935_1 1144305.PMI02_00146 5.7e-121 360.0 COG1053@1|root,COG1053@2|Bacteria,1MURY@1224|Proteobacteria,2UQ4B@28211|Alphaproteobacteria,2KD4E@204457|Sphingomonadales 204457|Sphingomonadales C HI0933-like protein - - 1.3.99.4 ko:K05898 ko00984,ko01100,ko01120,map00984,map01100,map01120 - R09884 RC00991 ko00000,ko00001,ko01000 - - - FAD_binding_2 k59_1220252_1 1415778.JQMM01000001_gene539 5.91e-24 94.4 COG1607@1|root,COG1607@2|Bacteria,1MZAZ@1224|Proteobacteria,1SA9N@1236|Gammaproteobacteria,1J65N@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria I Thioesterase superfamily yciA GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006163,GO:0006629,GO:0006631,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009150,GO:0009259,GO:0009987,GO:0016289,GO:0016787,GO:0016788,GO:0016790,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0033865,GO:0033875,GO:0034032,GO:0034641,GO:0035383,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0047617,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564 - ko:K10806 ko01040,map01040 - - - ko00000,ko00001,ko01000,ko01004 - - - 4HBT k59_1220252_2 105559.Nwat_1880 5.53e-32 113.0 COG0556@1|root,COG0556@2|Bacteria,1MUFK@1224|Proteobacteria,1RN6Z@1236|Gammaproteobacteria,1WW4U@135613|Chromatiales 135613|Chromatiales L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage uvrB - - ko:K03702 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - Helicase_C,ResIII,UVR,UvrB k59_482496_1 748247.AZKH_3280 3.95e-98 305.0 COG0365@1|root,COG0365@2|Bacteria,1MUX7@1224|Proteobacteria,2VKAN@28216|Betaproteobacteria,2KVQH@206389|Rhodocyclales 206389|Rhodocyclales I Acetyl-coenzyme A synthetase N-terminus - - 6.2.1.16 ko:K01907 ko00280,ko00650,map00280,map00650 - R01357 RC00004,RC00014 ko00000,ko00001,ko01000,ko01004 - - - ACAS_N,AMP-binding,AMP-binding_C k59_35695_1 1229909.NSED_03040 5.18e-140 409.0 COG1384@1|root,arCOG00485@2157|Archaea,41SB4@651137|Thaumarchaeota 651137|Thaumarchaeota J Belongs to the class-I aminoacyl-tRNA synthetase family lysS - 6.1.1.6 ko:K04566 ko00970,map00970 M00360 R03658 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_1f k59_1615696_1 1122137.AQXF01000001_gene3402 1.67e-88 273.0 COG3137@1|root,COG3137@2|Bacteria,1MWI4@1224|Proteobacteria,2U5G9@28211|Alphaproteobacteria 28211|Alphaproteobacteria M salt-induced outer membrane protein - - - ko:K07283 - - - - ko00000 - - - DUF481 k59_318809_1 95619.PM1_0201495 9.98e-42 151.0 COG0021@1|root,COG0021@2|Bacteria,1MUEY@1224|Proteobacteria,1RMWP@1236|Gammaproteobacteria 1236|Gammaproteobacteria G Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate tktA GO:0000302,GO:0003674,GO:0003824,GO:0004802,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006098,GO:0006139,GO:0006355,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009052,GO:0009117,GO:0009635,GO:0009636,GO:0009719,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010033,GO:0010035,GO:0010243,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016740,GO:0016744,GO:0019219,GO:0019222,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0019842,GO:0030145,GO:0030976,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032991,GO:0033554,GO:0034599,GO:0034614,GO:0034641,GO:0035690,GO:0036094,GO:0036245,GO:0042221,GO:0042493,GO:0042542,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045893,GO:0045935,GO:0046483,GO:0046496,GO:0046677,GO:0046872,GO:0046914,GO:0048037,GO:0048518,GO:0048522,GO:0050662,GO:0050789,GO:0050794,GO:0050896,GO:0051156,GO:0051171,GO:0051173,GO:0051186,GO:0051252,GO:0051254,GO:0051716,GO:0055086,GO:0060255,GO:0065007,GO:0070301,GO:0070887,GO:0071236,GO:0071310,GO:0071417,GO:0071495,GO:0071704,GO:0072524,GO:0072747,GO:0072756,GO:0080090,GO:0097159,GO:0097237,GO:1901135,GO:1901322,GO:1901360,GO:1901363,GO:1901562,GO:1901564,GO:1901654,GO:1901655,GO:1901681,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 - - iECABU_c1320.ECABU_c27750,iLF82_1304.LF82_2271,iNRG857_1313.NRG857_12300,iSDY_1059.SDY_3141,iYL1228.KPN_01127,iYL1228.KPN_02799,ic_1306.c2990 Transket_pyr,Transketolase_C,Transketolase_N k59_1505005_1 159087.Daro_3354 5.76e-42 156.0 COG2199@1|root,COG2200@1|root,COG2199@2|Bacteria,COG2200@2|Bacteria,1MUQV@1224|Proteobacteria,2VJ24@28216|Betaproteobacteria,2KZNZ@206389|Rhodocyclales 206389|Rhodocyclales T LapD/MoxY periplasmic domain - - - - - - - - - - - - EAL,GGDEF,LapD_MoxY_N k59_1505011_1 1286093.C266_00165 1.51e-63 198.0 COG0359@1|root,COG0359@2|Bacteria,1RD0R@1224|Proteobacteria,2VR40@28216|Betaproteobacteria,1K721@119060|Burkholderiaceae 28216|Betaproteobacteria J binds to the 23S rRNA rplI - - ko:K02939 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L9_C,Ribosomal_L9_N k59_823372_1 243231.GSU2838 1.38e-39 137.0 COG0200@1|root,COG0200@2|Bacteria,1RDC8@1224|Proteobacteria,42SRC@68525|delta/epsilon subdivisions,2WQQ4@28221|Deltaproteobacteria,43SHB@69541|Desulfuromonadales 28221|Deltaproteobacteria J binds to the 23S rRNA rplO GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - ko:K02876 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L27A k59_823372_2 880072.Desac_1436 3.71e-08 53.9 COG0201@1|root,COG0201@2|Bacteria,1MVU7@1224|Proteobacteria,42MGM@68525|delta/epsilon subdivisions,2WIZ7@28221|Deltaproteobacteria,2MQSV@213462|Syntrophobacterales 28221|Deltaproteobacteria U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently secY - - ko:K03076 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5 - - SecY k59_35716_1 1267534.KB906756_gene227 2.15e-18 89.7 COG2807@1|root,COG2807@2|Bacteria,3Y9E6@57723|Acidobacteria 57723|Acidobacteria P Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 k59_823373_1 1449126.JQKL01000009_gene318 1.36e-18 91.3 COG1197@1|root,COG1197@2|Bacteria,1TPF1@1239|Firmicutes,248D8@186801|Clostridia,267QU@186813|unclassified Clostridiales 186801|Clostridia L Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site mfd - - ko:K03723 ko03420,map03420 - - - ko00000,ko00001,ko01000,ko03400 - - - CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF k59_1105878_2 1122135.KB893146_gene1669 8.73e-05 43.9 COG0156@1|root,COG0156@2|Bacteria,1MVVH@1224|Proteobacteria,2TQXI@28211|Alphaproteobacteria 28211|Alphaproteobacteria E 5-aminolevulinic acid synthase - - - - - - - - - - - - Aminotran_1_2 k59_1616762_2 1485545.JQLW01000005_gene1138 3.8e-32 116.0 COG2050@1|root,COG2050@2|Bacteria 2|Bacteria Q thiolester hydrolase activity yiiD - - - - - - - - - - - 4HBT,DUF4442,YiiD_C k59_1506407_1 1165096.ARWF01000001_gene1170 9.35e-38 140.0 COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,2VJ57@28216|Betaproteobacteria,2KM0Q@206350|Nitrosomonadales 206350|Nitrosomonadales L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity polA - 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1 k59_1506407_2 1266925.JHVX01000003_gene556 2.69e-27 105.0 COG1611@1|root,COG1611@2|Bacteria,1MU6N@1224|Proteobacteria,2VK4I@28216|Betaproteobacteria,3723Z@32003|Nitrosomonadales 28216|Betaproteobacteria S Cytokinin riboside 5'-monophosphate phosphoribohydrolase yvdD_2 - 3.2.2.10 ko:K06966 ko00230,ko00240,map00230,map00240 - R00182,R00510 RC00063,RC00318 ko00000,ko00001,ko01000 - - - Lysine_decarbox k59_1221246_1 436308.Nmar_1004 5.53e-77 249.0 COG0405@1|root,arCOG04053@2157|Archaea 2157|Archaea E gamma-glutamyltransferase ggt - 2.3.2.2,3.4.19.13 ko:K00681 ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100 - R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935 RC00064,RC00090,RC00096 ko00000,ko00001,ko01000,ko01002 - - - G_glu_transpept k59_824816_1 546268.NEISUBOT_04076 3.51e-22 97.1 COG4591@1|root,COG4591@2|Bacteria,1MVV7@1224|Proteobacteria,2VH7C@28216|Betaproteobacteria,2KQ6C@206351|Neisseriales 206351|Neisseriales M lipoprotein releasing system, transmembrane protein, LolC E family lolC - - ko:K09808 ko02010,map02010 M00255 - - ko00000,ko00001,ko00002,ko02000 3.A.1.125 - - FtsX,MacB_PCD k59_824816_2 1437882.AZRU01000075_gene4450 7.45e-05 46.2 COG3216@1|root,COG3216@2|Bacteria,1RGV6@1224|Proteobacteria,1S682@1236|Gammaproteobacteria,1YCZQ@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria S Uncharacterized protein conserved in bacteria (DUF2062) TLL0138 - - ko:K09928 - - - - ko00000 - - - DUF2062 k59_483490_1 1122927.KB895417_gene3036 0.000317 48.1 COG0845@1|root,COG0845@2|Bacteria,1U081@1239|Firmicutes,4I9IS@91061|Bacilli,271MP@186822|Paenibacillaceae 91061|Bacilli M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - - - - - - - - - - - k59_714710_1 158500.BV97_02440 2.25e-163 475.0 COG0018@1|root,COG0018@2|Bacteria,1MU4J@1224|Proteobacteria,2TS3Y@28211|Alphaproteobacteria,2K0G5@204457|Sphingomonadales 204457|Sphingomonadales J Arginyl-tRNA synthetase argS - 6.1.1.19 ko:K01887 ko00970,map00970 M00359,M00360 R03646 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - Arg_tRNA_synt_N,DALR_1,tRNA-synt_1,tRNA-synt_1d,tRNA-synt_1f k59_1221251_1 1342302.JASC01000003_gene3623 1.82e-16 83.6 COG3488@1|root,COG3488@2|Bacteria,1Q802@1224|Proteobacteria,2VE5R@28211|Alphaproteobacteria,3ZYW4@60136|Sulfitobacter 28211|Alphaproteobacteria C Thiol oxidoreductase - - - - - - - - - - - - - k59_428122_1 279238.Saro_0278 4.05e-122 375.0 COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,2TRJF@28211|Alphaproteobacteria,2K1KW@204457|Sphingomonadales 204457|Sphingomonadales L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity polA - 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1 k59_92932_1 746697.Aeqsu_0912 3.7e-59 207.0 COG0204@1|root,COG4258@1|root,COG0204@2|Bacteria,COG4258@2|Bacteria,4PKBM@976|Bacteroidetes,1HYZW@117743|Flavobacteriia 976|Bacteroidetes I glycerol acyltransferase - - - ko:K07003 - - - - ko00000 - - - Acyltransferase,MMPL,Methyltransf_25,Methyltransf_31 k59_885202_1 394221.Mmar10_2684 4.31e-20 89.4 COG3383@1|root,COG3383@2|Bacteria,1QTZB@1224|Proteobacteria,2TVZI@28211|Alphaproteobacteria,4415E@69657|Hyphomonadaceae 28211|Alphaproteobacteria C Molybdopterin oxidoreductase Fe4S4 domain - - 1.17.1.9 ko:K00123 ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200 - R00519 RC02796 ko00000,ko00001,ko01000 - - - Fer2_4,Fer4,Fer4_6,Fer4_7,Fer4_9,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3 k59_885202_2 716928.AJQT01000024_gene3325 1.38e-29 116.0 COG1526@1|root,COG1526@2|Bacteria,1NRU0@1224|Proteobacteria,2TUD2@28211|Alphaproteobacteria,4B98G@82115|Rhizobiaceae 28211|Alphaproteobacteria C Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH fdhD - - ko:K02379 - - - - ko00000 - - - FdhD-NarQ k59_1393445_1 323850.Shew_1196 5.5e-42 154.0 COG0497@1|root,COG0497@2|Bacteria,1MUNP@1224|Proteobacteria,1RNPZ@1236|Gammaproteobacteria,2Q9MV@267890|Shewanellaceae 1236|Gammaproteobacteria L May be involved in recombinational repair of damaged DNA recN GO:0000724,GO:0000725,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009314,GO:0009432,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0090304,GO:1901360 - ko:K03631 - - - - ko00000,ko03400 - - - AAA_23,SMC_N k59_376794_3 391619.PGA1_c22420 5.69e-20 87.8 COG3740@1|root,COG3740@2|Bacteria,1N2D8@1224|Proteobacteria,2UD3U@28211|Alphaproteobacteria,34FI4@302485|Phaeobacter 28211|Alphaproteobacteria S Caudovirus prohead serine protease - - - ko:K06904 - - - - ko00000 - - - Peptidase_S78 k59_320338_1 248742.XP_005644137.1 9.56e-15 73.9 2CNPV@1|root,2S41B@2759|Eukaryota,381K6@33090|Viridiplantae,34N4Z@3041|Chlorophyta 3041|Chlorophyta - - - - - - - - - - - - - - - k59_320338_2 1380387.JADM01000001_gene489 4.02e-81 243.0 COG0386@1|root,COG0386@2|Bacteria,1RD1R@1224|Proteobacteria,1S425@1236|Gammaproteobacteria,1XJU2@135619|Oceanospirillales 135619|Oceanospirillales O Belongs to the glutathione peroxidase family - - 1.11.1.9 ko:K00432 ko00480,ko00590,ko04918,map00480,map00590,map04918 - R00274,R07034,R07035 RC00011,RC00982 ko00000,ko00001,ko01000 - - - GSHPx k59_320338_3 1460640.JCM19046_745 4.87e-08 55.5 COG0599@1|root,COG0599@2|Bacteria,1V78I@1239|Firmicutes,4HKFY@91061|Bacilli,1ZRAS@1386|Bacillus 91061|Bacilli S Carboxymuconolactone decarboxylase family - - 4.1.1.44 ko:K01607 ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220 - R03470 RC00938 ko00000,ko00001,ko01000 - - - CMD k59_320339_1 1283300.ATXB01000001_gene1471 4.02e-44 147.0 COG0691@1|root,COG0691@2|Bacteria,1RDFP@1224|Proteobacteria,1S3PT@1236|Gammaproteobacteria,1XF0N@135618|Methylococcales 135618|Methylococcales J Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene smpB - - ko:K03664 - - - - ko00000 - - - SmpB k59_204437_1 1112216.JH594425_gene52 8.43e-40 155.0 COG4206@1|root,COG4206@2|Bacteria,1R47X@1224|Proteobacteria,2TW6Q@28211|Alphaproteobacteria,2K1IJ@204457|Sphingomonadales 204457|Sphingomonadales H TonB dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_37172_2 1231392.OCGS_1320 7.23e-26 105.0 COG2981@1|root,COG2981@2|Bacteria,1MWAA@1224|Proteobacteria,2TT6E@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Protein involved in cysteine biosynthesis MA20_24505 - - ko:K06203 - - - - ko00000 - - - EI24 k59_1274470_1 251229.Chro_4000 6.85e-46 159.0 COG2135@1|root,COG2135@2|Bacteria,1G1SA@1117|Cyanobacteria,3VK4S@52604|Pleurocapsales 1117|Cyanobacteria S Belongs to the SOS response-associated peptidase family - - - - - - - - - - - - SRAP k59_885236_1 999611.KI421504_gene1092 3.18e-70 219.0 COG0087@1|root,COG0087@2|Bacteria,1MUST@1224|Proteobacteria,2TRHB@28211|Alphaproteobacteria,27ZYG@191028|Leisingera 28211|Alphaproteobacteria J Ribosomal protein L3 rplC - - ko:K02906 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L3 k59_885236_2 1122137.AQXF01000006_gene974 6.49e-16 73.9 COG0088@1|root,COG0088@2|Bacteria,1MXPF@1224|Proteobacteria,2TRUT@28211|Alphaproteobacteria 28211|Alphaproteobacteria J Forms part of the polypeptide exit tunnel rplD GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02926 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L4 k59_936044_1 1122939.ATUD01000009_gene3078 3.52e-05 49.7 COG1352@1|root,COG1352@2|Bacteria,2I99S@201174|Actinobacteria,4CSVF@84995|Rubrobacteria 84995|Rubrobacteria NT Methyltransferase, chemotaxis proteins - - 2.1.1.80 ko:K00575 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko01000,ko02035 - - - CheR k59_714753_1 1122137.AQXF01000002_gene147 4.84e-56 197.0 COG0658@1|root,COG0658@2|Bacteria,1MUKF@1224|Proteobacteria,2TRD5@28211|Alphaproteobacteria 28211|Alphaproteobacteria S membrane metal-binding protein - - - ko:K02238 - M00429 - - ko00000,ko00002,ko02044 3.A.11.1,3.A.11.2 - - Competence,DUF4131 k59_204454_1 1265505.ATUG01000002_gene2491 4.86e-62 209.0 COG4666@1|root,COG4666@2|Bacteria,1MUNB@1224|Proteobacteria,42MEV@68525|delta/epsilon subdivisions,2WK2S@28221|Deltaproteobacteria 28221|Deltaproteobacteria S TIGRFAM TRAP transporter, 4TM 12TM fusion protein - - - - - - - - - - - - DctM k59_885243_1 1278073.MYSTI_02771 1.46e-89 280.0 COG1362@1|root,COG1362@2|Bacteria,1NT1D@1224|Proteobacteria,42MN0@68525|delta/epsilon subdivisions,2WMBS@28221|Deltaproteobacteria,2YWEV@29|Myxococcales 28221|Deltaproteobacteria E M18 family aminopeptidase - - 3.4.11.21 ko:K01267 - - - - ko00000,ko01000,ko01002,ko04131 - - - Peptidase_M18 k59_936053_1 1123253.AUBD01000008_gene555 6.38e-80 267.0 COG5276@1|root,COG5276@2|Bacteria,1R66X@1224|Proteobacteria,1S05Q@1236|Gammaproteobacteria,1X429@135614|Xanthomonadales 135614|Xanthomonadales S LVIVD repeat - - - - - - - - - - - - LVIVD k59_824886_1 864069.MicloDRAFT_00052510 1.35e-103 311.0 COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,2TREJ@28211|Alphaproteobacteria,1JSX5@119045|Methylobacteriaceae 28211|Alphaproteobacteria I Acyl-CoA dehydrogenase, middle domain ivd2 - 1.3.8.4 ko:K00253 ko00280,ko01100,map00280,map01100 M00036 R04095 RC00246 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_146939_1 1122137.AQXF01000001_gene2743 2.19e-32 115.0 COG0139@1|root,COG0139@2|Bacteria,1MW67@1224|Proteobacteria,2UCKH@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP hisI - 3.5.4.19,3.6.1.31 ko:K01496,ko:K11755 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04035,R04037 RC00002,RC01055 ko00000,ko00001,ko00002,ko01000 - - - PRA-CH,PRA-PH k59_146939_2 1122137.AQXF01000001_gene2744 3.76e-31 118.0 COG3591@1|root,COG3591@2|Bacteria,1MXUN@1224|Proteobacteria,2TT3R@28211|Alphaproteobacteria 28211|Alphaproteobacteria E COG3591 V8-like Glu-specific endopeptidase - - - ko:K04775 - - - - ko00000,ko01000,ko01002 - - - Trypsin,Trypsin_2 k59_538696_1 316407.85675867 2.41e-137 402.0 COG0358@1|root,COG0358@2|Bacteria,1MUHC@1224|Proteobacteria,1RMGA@1236|Gammaproteobacteria,3XNFD@561|Escherichia 1236|Gammaproteobacteria L RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication dnaG GO:0003674,GO:0003824,GO:0003896,GO:0003899,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006269,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576 - ko:K02316 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB_bind,DnaG_DnaB_bind,Toprim_2,Toprim_4,Toprim_N,zf-CHC2 k59_428177_1 713586.KB900536_gene2400 4.82e-17 79.0 COG3863@1|root,COG3863@2|Bacteria,1RBGX@1224|Proteobacteria,1S01D@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family yiiX - - - - - - - - - - - Peptidase_C92 k59_428177_2 1121011.AUCB01000021_gene3747 6.02e-13 69.3 COG2020@1|root,COG2020@2|Bacteria,4NPVN@976|Bacteroidetes,1I2QK@117743|Flavobacteriia,23HCX@178469|Arenibacter 976|Bacteroidetes O Isoprenylcysteine carboxyl methyltransferase (ICMT) family - - - - - - - - - - - - PEMT k59_1401574_1 187272.Mlg_1415 1.07e-31 125.0 COG0470@1|root,COG0470@2|Bacteria,1MY1W@1224|Proteobacteria,1RNYA@1236|Gammaproteobacteria,1WW0S@135613|Chromatiales 135613|Chromatiales L DNA polymerase III, delta' - - 2.7.7.7 ko:K02341 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_delta2,DNApol3-delta_C k59_546844_2 999541.bgla_1g03090 8e-77 231.0 COG0197@1|root,COG0197@2|Bacteria,1RA0Z@1224|Proteobacteria,2VQ0A@28216|Betaproteobacteria,1K6XR@119060|Burkholderiaceae 28216|Betaproteobacteria J Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs rplP - - ko:K02878 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L16 k59_546844_3 556268.OFAG_01968 9.01e-24 91.3 COG0255@1|root,COG0255@2|Bacteria,1N6PR@1224|Proteobacteria,2VVNT@28216|Betaproteobacteria,4752D@75682|Oxalobacteraceae 28216|Betaproteobacteria J Belongs to the universal ribosomal protein uL29 family rpmC - - ko:K02904 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L29 k59_546844_4 1121035.AUCH01000026_gene3350 2.07e-25 97.1 COG0186@1|root,COG0186@2|Bacteria,1MZIK@1224|Proteobacteria,2VU2G@28216|Betaproteobacteria,2KX1P@206389|Rhodocyclales 206389|Rhodocyclales J One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA rpsQ - - ko:K02961 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S17 k59_1338874_1 420662.Mpe_A1898 3.33e-54 183.0 COG0161@1|root,COG0161@2|Bacteria,1MU2N@1224|Proteobacteria,2VKRZ@28216|Betaproteobacteria,1KITC@119065|unclassified Burkholderiales 28216|Betaproteobacteria H Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family - - 2.6.1.18 ko:K00822 ko00280,ko00410,ko00640,ko01100,map00280,map00410,map00640,map01100 - R00907,R04187 RC00008,RC00062,RC00160 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_3 k59_1736775_1 498211.CJA_3218 1.05e-71 227.0 COG0196@1|root,COG0196@2|Bacteria,1MV9I@1224|Proteobacteria,1RN44@1236|Gammaproteobacteria,1FGS1@10|Cellvibrio 1236|Gammaproteobacteria H Riboflavin kinase ribF GO:0003674,GO:0003824,GO:0003919,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008531,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016779,GO:0044237,GO:0070566 2.7.1.26,2.7.7.2 ko:K11753 ko00740,ko01100,ko01110,map00740,map01100,map01110 M00125 R00161,R00549 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - iETEC_1333.ETEC_0025,iJN746.PP_0602 FAD_syn,Flavokinase k59_154898_1 1049564.TevJSym_ar00340 9.72e-14 80.9 COG1729@1|root,COG1729@2|Bacteria,1MZ7N@1224|Proteobacteria,1T3FY@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division - - - - - - - - - - - - - k59_1736777_1 1121937.AUHJ01000001_gene612 4.44e-84 276.0 COG1060@1|root,COG1060@2|Bacteria,1MX50@1224|Proteobacteria,1RSCG@1236|Gammaproteobacteria,4668T@72275|Alteromonadaceae 1236|Gammaproteobacteria H Elongator protein 3, MiaB family, Radical SAM - - 2.5.1.77 ko:K11779 ko00680,ko01120,map00680,map01120 M00378 R09396 RC01381,RC03002,RC03007 ko00000,ko00001,ko00002,ko01000 - - - CofC,Radical_SAM k59_1789128_1 316407.1736416 3.13e-116 341.0 COG2807@1|root,COG2807@2|Bacteria,1MXGT@1224|Proteobacteria,1RNWA@1236|Gammaproteobacteria,3XMU7@561|Escherichia 1236|Gammaproteobacteria P response to antibiotic yeaN GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0042221,GO:0044464,GO:0046677,GO:0050896,GO:0071944 - ko:K03449 - - - - ko00000,ko02000 2.A.1.17 - - MFS_1 k59_662003_1 1288298.rosmuc_00350 2.35e-110 327.0 COG0687@1|root,COG0687@2|Bacteria,1Q2AN@1224|Proteobacteria,2U1XB@28211|Alphaproteobacteria,46PW8@74030|Roseovarius 28211|Alphaproteobacteria E Bacterial extracellular solute-binding protein - - - ko:K11069 ko02010,map02010 M00299 - - ko00000,ko00001,ko00002,ko02000 3.A.1.11.1 - - SBP_bac_8 k59_1514067_1 1341155.FSS13T_25470 2.75e-53 172.0 2DKWX@1|root,30NTZ@2|Bacteria,4NNFM@976|Bacteroidetes,1I2I2@117743|Flavobacteriia,2NX1U@237|Flavobacterium 976|Bacteroidetes - - - - - - - - - - - - - - - k59_943874_1 1479239.JQMU01000001_gene1824 5.57e-15 73.2 COG1062@1|root,COG1062@2|Bacteria,1MUK4@1224|Proteobacteria,2TT67@28211|Alphaproteobacteria,2K04T@204457|Sphingomonadales 204457|Sphingomonadales C Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily - - 1.1.1.1,1.1.1.284 ko:K00121 ko00010,ko00071,ko00350,ko00625,ko00626,ko00680,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,ko05204,map00010,map00071,map00350,map00625,map00626,map00680,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01200,map01220,map05204 - R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R06983,R07105,R08281,R08306,R08310 RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01715,RC01734,RC02273 ko00000,ko00001,ko01000 - - - ADH_N,ADH_zinc_N k59_943874_2 1457393.AZ09_03880 1.15e-18 82.8 COG0346@1|root,COG0346@2|Bacteria,1RH8G@1224|Proteobacteria,2U9BR@28211|Alphaproteobacteria,2JU26@204441|Rhodospirillales 204441|Rhodospirillales E Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - - - - - - - - - - Glyoxalase k59_943874_3 555793.WSK_2268 2.83e-59 189.0 COG0627@1|root,COG0627@2|Bacteria,1MUID@1224|Proteobacteria,2TQSM@28211|Alphaproteobacteria,2K143@204457|Sphingomonadales 204457|Sphingomonadales S Serine hydrolase involved in the detoxification of formaldehyde fghA - 3.1.2.12 ko:K01070 ko00680,ko01120,ko01200,map00680,map01120,map01200 - R00527 RC00167,RC00320 ko00000,ko00001,ko01000 - CE1 - Esterase k59_1338884_1 1380390.JIAT01000011_gene2866 3.03e-07 54.7 COG1329@1|root,COG1329@2|Bacteria,2GKSU@201174|Actinobacteria,4CPVJ@84995|Rubrobacteria 84995|Rubrobacteria K CarD-like/TRCF domain - - - ko:K07736 - - - - ko00000,ko03000 - - - CarD_CdnL_TRCF k59_1571543_1 1379270.AUXF01000006_gene133 1.3e-113 335.0 COG1077@1|root,COG1077@2|Bacteria,1ZT9B@142182|Gemmatimonadetes 142182|Gemmatimonadetes D Hsp70 protein - - - ko:K03569 - - - - ko00000,ko02048,ko03036,ko04812 1.A.33.1,9.B.157.1 - - MreB_Mbl k59_327888_1 1469245.JFBG01000003_gene397 2.35e-42 146.0 COG1215@1|root,COG1215@2|Bacteria,1RA75@1224|Proteobacteria,1S3RM@1236|Gammaproteobacteria 1236|Gammaproteobacteria M COG0463 Glycosyltransferases involved in cell wall biogenesis - - - - - - - - - - - - Glycos_transf_2 k59_327888_2 1121374.KB891592_gene2960 4.08e-08 53.9 COG3222@1|root,COG3222@2|Bacteria,1RB1V@1224|Proteobacteria,1S971@1236|Gammaproteobacteria 1236|Gammaproteobacteria M protein conserved in bacteria - - - ko:K09931 - - - - ko00000 - - - DUF2064 k59_384558_1 1121013.P873_12400 1.07e-98 312.0 COG0189@1|root,COG0769@1|root,COG0189@2|Bacteria,COG0769@2|Bacteria,1MVN2@1224|Proteobacteria,1RS1C@1236|Gammaproteobacteria,1X7FN@135614|Xanthomonadales 135614|Xanthomonadales HJ Prokaryotic glutathione synthetase, ATP-grasp domain - - 6.3.2.29,6.3.2.30 ko:K03802 - - - - ko00000,ko01000 - - - Acetyltransf_1,Mur_ligase_C,Mur_ligase_M,RimK k59_1113677_1 379066.GAU_1909 1.49e-29 116.0 COG2256@1|root,COG2256@2|Bacteria,1ZTCA@142182|Gemmatimonadetes 142182|Gemmatimonadetes L MgsA AAA+ ATPase C terminal - - - ko:K07478 - - - - ko00000 - - - AAA_assoc_2,MgsA_C,RuvB_N k59_1113677_2 1379698.RBG1_1C00001G1352 5.82e-10 60.5 COG0428@1|root,COG0428@2|Bacteria,2NQ6J@2323|unclassified Bacteria 2|Bacteria P ZIP Zinc transporter zupT - - ko:K07238,ko:K11021,ko:K16267 - - - - ko00000,ko02000,ko02042 2.A.5.4.11,2.A.5.5 - - Zip k59_663060_1 857087.Metme_4033 4.77e-22 90.9 2AMYE@1|root,31CVH@2|Bacteria,1NT8E@1224|Proteobacteria,1SMY1@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_833578_1 1121033.AUCF01000007_gene5876 8.23e-101 306.0 COG0065@1|root,COG0065@2|Bacteria,1MVYR@1224|Proteobacteria,2TR6K@28211|Alphaproteobacteria,2JQ8V@204441|Rhodospirillales 204441|Rhodospirillales E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate leuC - 4.2.1.33,4.2.1.35 ko:K01703 ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230 M00432,M00535 R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170 RC00497,RC00976,RC00977,RC01041,RC01046,RC03072 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase k59_1283935_1 717774.Marme_2239 7.57e-117 345.0 COG0082@1|root,COG0082@2|Bacteria,1MU98@1224|Proteobacteria,1RMQS@1236|Gammaproteobacteria,1XHJ7@135619|Oceanospirillales 135619|Oceanospirillales E Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system aroC - 4.2.3.5 ko:K01736 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R01714 RC00586 ko00000,ko00001,ko00002,ko01000 - - - Chorismate_synt k59_1114929_2 399739.Pmen_3801 5.89e-08 53.5 COG1057@1|root,COG1057@2|Bacteria,1RD0J@1224|Proteobacteria,1RP00@1236|Gammaproteobacteria,1YDGR@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria H Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) nadD GO:0000309,GO:0003674,GO:0003824,GO:0004515,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019365,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0034355,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0043094,GO:0043173,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0070566,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.7.7.18,3.5.4.4 ko:K00969,ko:K01488 ko00230,ko00760,ko01100,ko05340,map00230,map00760,map01100,map05340 M00115 R00137,R01560,R02556,R03005 RC00002,RC00477 ko00000,ko00001,ko00002,ko01000 - - iECUMN_1333.ECUMN_0733,iJN746.PP_4810,iPC815.YPO2607,iSbBS512_1146.SbBS512_E0612 CTP_transf_like k59_1625545_1 288000.BBta_7789 3.69e-87 280.0 COG0542@1|root,COG0542@2|Bacteria,1MURH@1224|Proteobacteria,2TRKI@28211|Alphaproteobacteria,3JRD0@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria O Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE clpB - - ko:K03695 ko04213,map04213 - - - ko00000,ko00001,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N k59_271154_1 1121921.KB898706_gene3288 7.21e-46 164.0 COG0534@1|root,COG0534@2|Bacteria,1MV6B@1224|Proteobacteria,1RPGF@1236|Gammaproteobacteria,2PMVI@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria V MatE dinF - - ko:K03327 - - - - ko00000,ko02000 2.A.66.1 - - MatE k59_1453655_2 1229909.NSED_09505 3.58e-05 45.1 COG0462@1|root,arCOG00067@2157|Archaea,41SH1@651137|Thaumarchaeota 651137|Thaumarchaeota F Ribose-phosphate pyrophosphokinase - - 2.7.6.1 ko:K00948 ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230 M00005 R01049 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - Pribosyl_synth,Pribosyltran,Pribosyltran_N k59_1572738_1 377629.TERTU_3621 9.49e-101 313.0 COG0577@1|root,COG1136@1|root,COG0577@2|Bacteria,COG1136@2|Bacteria,1MU45@1224|Proteobacteria,1RNUJ@1236|Gammaproteobacteria,2PMN2@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria V FtsX-like permease family macB GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006855,GO:0008144,GO:0008150,GO:0008559,GO:0015238,GO:0015399,GO:0015405,GO:0015893,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0030554,GO:0031224,GO:0031226,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0035639,GO:0036094,GO:0042221,GO:0042493,GO:0042623,GO:0042626,GO:0042802,GO:0042891,GO:0042895,GO:0042908,GO:0042910,GO:0043167,GO:0043168,GO:0043492,GO:0044425,GO:0044459,GO:0044464,GO:0046618,GO:0046677,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0097159,GO:0097367,GO:0098796,GO:1901265,GO:1901363,GO:1902495,GO:1990195,GO:1990196,GO:1990351 - ko:K05685 ko02010,map02010 M00709 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.122.1,3.A.1.122.12 - - ABC_tran,FtsX,MacB_PCD k59_1114947_1 1380390.JIAT01000010_gene4115 3.21e-06 54.3 COG1309@1|root,COG1309@2|Bacteria,2HNXD@201174|Actinobacteria,4CRAW@84995|Rubrobacteria 84995|Rubrobacteria K Bacterial regulatory proteins, tetR family - - - - - - - - - - - - TetR_N k59_1114947_2 1282876.BAOK01000002_gene502 2.32e-63 206.0 COG0208@1|root,COG0208@2|Bacteria,1R4T3@1224|Proteobacteria,2U55H@28211|Alphaproteobacteria 28211|Alphaproteobacteria F P-aminobenzoate N-oxygenase AurF - - - - - - - - - - - - AurF k59_1625551_1 1121935.AQXX01000144_gene4428 2.75e-62 224.0 COG0642@1|root,COG5000@1|root,COG0642@2|Bacteria,COG2205@2|Bacteria,COG5000@2|Bacteria,1NRP8@1224|Proteobacteria,1SKTW@1236|Gammaproteobacteria,1XNGF@135619|Oceanospirillales 135619|Oceanospirillales T Histidine kinase - - - - - - - - - - - - CHASE,HATPase_c,HisKA,Hpt,PAS,PAS_3,PAS_9,Response_reg,dCache_1 k59_894364_1 1122613.ATUP01000002_gene2418 8.01e-114 350.0 COG0154@1|root,COG0154@2|Bacteria,1MWRI@1224|Proteobacteria,2TTJU@28211|Alphaproteobacteria,440XC@69657|Hyphomonadaceae 28211|Alphaproteobacteria J COG0154 Asp-tRNAAsn Glu-tRNAGln amidotransferase A subunit and related amidases - - 3.5.1.4,6.3.5.6,6.3.5.7 ko:K01426,ko:K02433 ko00330,ko00360,ko00380,ko00627,ko00643,ko00970,ko01100,ko01120,map00330,map00360,map00380,map00627,map00643,map00970,map01100,map01120 - R02540,R03096,R03180,R03905,R03909,R04212,R05551,R05590 RC00010,RC00100,RC00950,RC01025 ko00000,ko00001,ko01000,ko03029 - - - Amidase k59_1737879_1 326424.FRAAL6799 1.69e-41 158.0 COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,2GKXV@201174|Actinobacteria,4ERWB@85013|Frankiales 201174|Actinobacteria C PFAM Pyruvate flavodoxin ferredoxin oxidoreductase - - 1.2.7.11,1.2.7.3 ko:K00174 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - PFOR_II,POR,POR_N k59_271188_2 1123242.JH636436_gene162 6.48e-09 59.3 COG1073@1|root,COG1073@2|Bacteria 2|Bacteria S thiolester hydrolase activity - - - - - - - - - - - - Abhydrolase_6,Hydrolase_4,Polysacc_synt_3,Polysacc_synt_C k59_1283976_1 765913.ThidrDRAFT_2321 9.04e-23 97.4 COG0388@1|root,COG0388@2|Bacteria,1MUUB@1224|Proteobacteria,1RNVZ@1236|Gammaproteobacteria,1WW30@135613|Chromatiales 135613|Chromatiales S Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase - - - ko:K11206 - - - - ko00000,ko01000 - - - CN_hydrolase k59_663097_1 479434.Sthe_3501 1.09e-74 239.0 COG1012@1|root,COG1012@2|Bacteria,2G5JZ@200795|Chloroflexi,27Y57@189775|Thermomicrobia 2|Bacteria C Belongs to the aldehyde dehydrogenase family putA - 1.2.1.88,1.5.5.2 ko:K00294,ko:K13821 ko00250,ko00330,ko01100,ko01110,ko01130,map00250,map00330,map01100,map01110,map01130 - R00245,R00707,R00708,R01253,R04444,R04445,R05051 RC00080,RC00083,RC00216,RC00242,RC00255 ko00000,ko00001,ko01000,ko03000 - - iAF987.Gmet_3512 Aldedh,Pro_dh,Pro_dh-DNA_bdg k59_663099_1 234267.Acid_2554 2.87e-30 122.0 COG3344@1|root,COG3344@2|Bacteria 2|Bacteria L reverse transcriptase - - 2.7.7.49 ko:K00986 - - - - ko00000,ko01000 - - - GIIM,RVT_1 k59_663099_2 222534.KB893766_gene2941 5.17e-16 82.8 COG1961@1|root,COG1961@2|Bacteria,2I8HV@201174|Actinobacteria 201174|Actinobacteria L COG1961 Site-specific recombinases, DNA invertase Pin homologs - - - - - - - - - - - - Recombinase,Resolvase,Zn_ribbon_recom k59_436836_2 1122137.AQXF01000003_gene2134 2.79e-224 633.0 COG2133@1|root,COG2133@2|Bacteria,1MVK5@1224|Proteobacteria,2TRN9@28211|Alphaproteobacteria 28211|Alphaproteobacteria G glucose sorbosone MA20_25025 - - - - - - - - - - - GSDH k59_1625568_1 477184.KYC_08760 6.28e-09 55.1 COG3255@1|root,COG3255@2|Bacteria,1RG3A@1224|Proteobacteria,2VX1T@28216|Betaproteobacteria,3T80I@506|Alcaligenaceae 28216|Betaproteobacteria I Sterol carrier protein - - - - - - - - - - - - - k59_1625568_2 398525.KB900701_gene5786 1.7e-127 369.0 COG0596@1|root,COG0596@2|Bacteria,1NUT9@1224|Proteobacteria,2TVMS@28211|Alphaproteobacteria,3JUAG@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S Putative esterase - - - - - - - - - - - - Abhydrolase_1 k59_1173776_1 199310.c4345 2.48e-164 483.0 COG1215@1|root,COG1215@2|Bacteria,1MWF8@1224|Proteobacteria,1RPJ6@1236|Gammaproteobacteria,3XM9Y@561|Escherichia 1236|Gammaproteobacteria M Catalytic subunit of cellulose synthase. It polymerizes uridine 5'-diphosphate glucose to cellulose, which is produced as an extracellular component for mechanical and chemical protection at the onset of the stationary phase, when the cells exhibit multicellular behavior (rdar morphotype). Coexpression of cellulose and thin aggregative fimbriae bcsA GO:0000271,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0005976,GO:0006073,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0016020,GO:0016051,GO:0030243,GO:0030244,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044464,GO:0051273,GO:0051274,GO:0071704,GO:0071944,GO:0090540,GO:1901576 2.4.1.12 ko:K00694,ko:K20541 ko00500,ko01100,ko02026,map00500,map01100,map02026 - R02889 RC00005 ko00000,ko00001,ko01000,ko01003,ko02000 4.D.3.1.2,4.D.3.1.5,4.D.3.1.6 GT2 - Cellulose_synt,Glyco_hydro_17,Glyco_tranf_2_3,Glycos_transf_2,PilZ k59_1229761_1 1282876.BAOK01000001_gene2250 7.36e-87 270.0 COG3386@1|root,COG3386@2|Bacteria,1NIN4@1224|Proteobacteria,2U3KK@28211|Alphaproteobacteria 28211|Alphaproteobacteria G Major royal jelly protein - - - - - - - - - - - - MRJP k59_101583_1 555088.DealDRAFT_2821 1.52e-16 82.4 COG1030@1|root,COG1030@2|Bacteria,1TR54@1239|Firmicutes,247N5@186801|Clostridia,42KMS@68298|Syntrophomonadaceae 186801|Clostridia O NfeD-like C-terminal, partner-binding yqeZ - - ko:K07403 - - - - ko00000 - - - CLP_protease,NfeD,SDH_sah k59_101583_2 1396141.BATP01000040_gene2109 4.44e-20 87.8 COG0452@1|root,COG0452@2|Bacteria,46WUX@74201|Verrucomicrobia,2IU6G@203494|Verrucomicrobiae 203494|Verrucomicrobiae H DNA / pantothenate metabolism flavoprotein - - 6.3.2.5 ko:K21977 ko00770,map00770 M00120 R04231 RC00064,RC00090 ko00000,ko00001,ko00002,ko01000 - - - DFP k59_385842_1 1041930.Mtc_0845 1.78e-09 63.5 COG0642@1|root,arCOG02338@1|root,arCOG02338@2157|Archaea,arCOG07619@2157|Archaea,2Y7TB@28890|Euryarchaeota,2NBMD@224756|Methanomicrobia 224756|Methanomicrobia T GAF domain - - - - - - - - - - - - GAF_2,HATPase_c,HisKA k59_271216_1 349965.yinte0001_31960 5.36e-59 195.0 COG1015@1|root,COG1015@2|Bacteria,1MVN8@1224|Proteobacteria,1RQ6W@1236|Gammaproteobacteria,41EDE@629|Yersinia 1236|Gammaproteobacteria G Phosphotransfer between the C1 and C5 carbon atoms of pentose deoB GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008973,GO:0009056,GO:0009058,GO:0009117,GO:0009166,GO:0009262,GO:0009264,GO:0009987,GO:0016853,GO:0016866,GO:0016868,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0033554,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046434,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0055086,GO:0071704,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576 5.4.2.7 ko:K01839 ko00030,ko00230,map00030,map00230 - R01057,R02749 RC00408 ko00000,ko00001,ko01000 - - iLF82_1304.LF82_0465,iNRG857_1313.NRG857_22165 Metalloenzyme k59_610889_1 1125971.ASJB01000080_gene7520 1.49e-08 59.3 COG1680@1|root,COG1680@2|Bacteria,2GIX5@201174|Actinobacteria 201174|Actinobacteria V Beta-lactamase - - - - - - - - - - - - Beta-lactamase k59_610889_2 1144307.PMI04_03443 9.76e-05 45.8 COG1619@1|root,COG1619@2|Bacteria,1MWIY@1224|Proteobacteria,2U2WH@28211|Alphaproteobacteria,2KCB6@204457|Sphingomonadales 204457|Sphingomonadales V LD-carboxypeptidase - - 3.4.17.13 ko:K01297 - - - - ko00000,ko01000,ko01002,ko01011 - - - Peptidase_S66 k59_1173790_1 1226994.AMZB01000048_gene3882 1.18e-49 165.0 COG1247@1|root,COG1247@2|Bacteria,1RGU8@1224|Proteobacteria,1S791@1236|Gammaproteobacteria 1236|Gammaproteobacteria M COG1247 Sortase and related acyltransferases - - 2.3.1.183 ko:K03823 ko00440,ko01130,map00440,map01130 - R08871,R08938 RC00004,RC00064 ko00000,ko00001,ko01000 - - - Acetyltransf_4 k59_663113_1 203122.Sde_0091 7.17e-99 296.0 COG4221@1|root,COG4221@2|Bacteria,1MUF8@1224|Proteobacteria,1RMKM@1236|Gammaproteobacteria,465F7@72275|Alteromonadaceae 1236|Gammaproteobacteria S Belongs to the short-chain dehydrogenases reductases (SDR) family ydfG GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006206,GO:0006208,GO:0006212,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009112,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0017144,GO:0019860,GO:0031132,GO:0034641,GO:0035527,GO:0042737,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046113,GO:0046483,GO:0046700,GO:0055086,GO:0055114,GO:0071704,GO:0072527,GO:0072529,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575 1.1.1.276,1.1.1.313,1.1.1.381 ko:K05886,ko:K15373,ko:K16066 ko00240,ko00260,ko00430,ko01100,map00240,map00260,map00430,map01100 - R02600,R09289,R10851,R10852 RC00087,RC00525,RC03288 ko00000,ko00001,ko01000 - - - adh_short k59_1115005_1 999541.bgla_1g35660 2.12e-92 281.0 COG1960@1|root,COG1960@2|Bacteria,1MVJC@1224|Proteobacteria,2VIQT@28216|Betaproteobacteria,1JZSR@119060|Burkholderiaceae 28216|Betaproteobacteria C acyl-CoA dehydrogenase - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_271222_1 566466.NOR53_23 1.97e-26 107.0 COG0475@1|root,COG0475@2|Bacteria 2|Bacteria P glutathione-regulated potassium exporter activity napA GO:0003674,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0006812,GO:0006814,GO:0008150,GO:0008324,GO:0009847,GO:0015075,GO:0015077,GO:0015081,GO:0015291,GO:0015297,GO:0015318,GO:0015672,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0022890,GO:0030001,GO:0031224,GO:0032502,GO:0034220,GO:0035725,GO:0044425,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0098655,GO:0098660,GO:0098662 - - - - - - - - - - Na_H_Exchanger k59_271222_2 1122137.AQXF01000007_gene3506 1.53e-37 126.0 COG0828@1|root,COG0828@2|Bacteria,1MZA1@1224|Proteobacteria,2UC58@28211|Alphaproteobacteria 28211|Alphaproteobacteria J Belongs to the bacterial ribosomal protein bS21 family rpsU GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:1990904 - ko:K02970 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S21 k59_271222_3 1122137.AQXF01000007_gene3507 7.89e-18 80.1 COG5590@1|root,COG5590@2|Bacteria,1MW25@1224|Proteobacteria,2U9ST@28211|Alphaproteobacteria 28211|Alphaproteobacteria S rpsU-divergently transcribed protein cOQ9 - - ko:K18587 - - - - ko00000 - - - COQ9 k59_101602_1 543728.Vapar_0781 5.34e-52 175.0 COG0697@1|root,COG0697@2|Bacteria,1MXJ6@1224|Proteobacteria,2VIA7@28216|Betaproteobacteria,4AHW3@80864|Comamonadaceae 28216|Betaproteobacteria EG EamA-like transporter family - - - - - - - - - - - - EamA k59_45632_1 1219035.NT2_01_03330 2.43e-61 194.0 COG0755@1|root,COG0755@2|Bacteria,1MU61@1224|Proteobacteria,2TSW8@28211|Alphaproteobacteria,2K13J@204457|Sphingomonadales 204457|Sphingomonadales O Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes ccmC - - ko:K02195 ko02010,map02010 M00259 - - ko00000,ko00001,ko00002,ko02000 3.A.1.107 - - Cytochrom_C_asm k59_1402930_1 511051.CSE_13200 1.11e-38 147.0 COG1197@1|root,COG1197@2|Bacteria 2|Bacteria L transcription-coupled nucleotide-excision repair, DNA damage recognition mfd - 2.4.1.129,3.4.16.4 ko:K03723,ko:K05365 ko00550,ko03420,map00550,map03420 - R04519 RC00005,RC00049 ko00000,ko00001,ko01000,ko01003,ko01011,ko03400 - GT51 - CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF k59_492533_1 1203606.HMPREF1526_02110 9.16e-44 159.0 COG0493@1|root,COG0493@2|Bacteria,1TQ1A@1239|Firmicutes,248EK@186801|Clostridia,36E1P@31979|Clostridiaceae 186801|Clostridia C glutamate synthase (NADPH), homotetrameric gltA - 1.17.1.9,1.4.1.13,1.4.1.14 ko:K00123,ko:K00266 ko00250,ko00630,ko00680,ko00910,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00250,map00630,map00680,map00910,map01100,map01110,map01120,map01130,map01200,map01230 - R00093,R00114,R00248,R00519 RC00006,RC00010,RC02796,RC02799 ko00000,ko00001,ko01000 - - - Fer4_20,Pyr_redox_2 k59_1737927_1 645465.ACUR01000391_gene3156 7.22e-16 80.9 COG0546@1|root,COG0546@2|Bacteria,2I9FC@201174|Actinobacteria 201174|Actinobacteria S Had-superfamily hydrolase, subfamily ia, variant 1 rifM - - ko:K16017 ko01051,ko01130,map01051,map01130 - R06587 RC00078 ko00000,ko00001 - - - HAD_2 k59_101614_1 420324.KI912020_gene7594 1.16e-27 102.0 COG2849@1|root,COG2849@2|Bacteria,1NFB6@1224|Proteobacteria,2UH63@28211|Alphaproteobacteria 28211|Alphaproteobacteria S repeat protein - - - - - - - - - - - - - k59_1515366_1 348824.LPU83_2922 2.7e-45 166.0 COG2114@1|root,COG2888@1|root,COG3899@1|root,COG2114@2|Bacteria,COG2888@2|Bacteria,COG3899@2|Bacteria,1MUDT@1224|Proteobacteria,2TQVN@28211|Alphaproteobacteria,4B81Q@82115|Rhizobiaceae 28211|Alphaproteobacteria T Adenylate - - 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 - - - AAA_16,DZR,Guanylate_cyc,TPR_12 k59_610926_1 240016.ABIZ01000001_gene963 1.97e-72 239.0 28HMZ@1|root,2Z7WD@2|Bacteria,46TFX@74201|Verrucomicrobia,2IVCD@203494|Verrucomicrobiae 203494|Verrucomicrobiae S Protein of unknown function (DUF3604) - - - - - - - - - - - - DUF3604 k59_833677_1 1388763.O165_022040 7.02e-12 67.8 COG0403@1|root,COG1003@1|root,COG0403@2|Bacteria,COG1003@2|Bacteria,1MUDP@1224|Proteobacteria,1RND3@1236|Gammaproteobacteria,1YXU3@136845|Pseudomonas putida group 1236|Gammaproteobacteria E Glycine cleavage system P-protein gcvP GO:0001505,GO:0003674,GO:0003824,GO:0004375,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005960,GO:0006082,GO:0006520,GO:0006544,GO:0006546,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009069,GO:0009071,GO:0009987,GO:0016054,GO:0016491,GO:0016638,GO:0016642,GO:0017144,GO:0019464,GO:0019752,GO:0032991,GO:0042133,GO:0042135,GO:0042737,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0055114,GO:0065007,GO:0065008,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606,GO:1902494,GO:1990204 1.4.4.2 ko:K00281,ko:K00283 ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200 M00532 R01221,R03425 RC00022,RC00929,RC02834,RC02880 ko00000,ko00001,ko00002,ko01000 - - iECIAI39_1322.ECIAI39_3318 GDC-P k59_833677_2 1051985.l11_03270 1.36e-18 80.9 COG0509@1|root,COG0509@2|Bacteria,1RGV7@1224|Proteobacteria,2VSD7@28216|Betaproteobacteria,2KRA0@206351|Neisseriales 206351|Neisseriales E The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein gcvH - - ko:K02437 ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200 M00532 R01221 RC00022,RC02834 ko00000,ko00001,ko00002 - - - GCV_H k59_1173821_1 491916.RHECIAT_CH0000243 3.75e-16 77.8 COG1015@1|root,COG1015@2|Bacteria,1MVN8@1224|Proteobacteria,2TRMP@28211|Alphaproteobacteria,4BAKS@82115|Rhizobiaceae 28211|Alphaproteobacteria G Phosphotransfer between the C1 and C5 carbon atoms of pentose deoB - 5.4.2.7 ko:K01839 ko00030,ko00230,map00030,map00230 - R01057,R02749 RC00408 ko00000,ko00001,ko01000 - - - Metalloenzyme k59_1173821_2 1122137.AQXF01000005_gene1196 1.94e-45 154.0 28JIP@1|root,2Z82C@2|Bacteria,1R5N9@1224|Proteobacteria,2U95E@28211|Alphaproteobacteria 28211|Alphaproteobacteria S S1/P1 Nuclease - - - - - - - - - - - - S1-P1_nuclease k59_1515378_1 436308.Nmar_1047 1.27e-87 286.0 arCOG03561@1|root,arCOG05978@1|root,arCOG06534@1|root,arCOG03561@2157|Archaea,arCOG05978@2157|Archaea,arCOG06534@2157|Archaea 2157|Archaea S acid phosphatase activity - - - - - - - - - - - - He_PIG,NHL,Tail_P2_I k59_1737945_1 521719.ATXQ01000010_gene12 1.26e-50 178.0 COG0608@1|root,COG0608@2|Bacteria,1MU1M@1224|Proteobacteria,1RMF4@1236|Gammaproteobacteria,1YD0H@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria L DHH family recJ GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0006139,GO:0006259,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008297,GO:0008409,GO:0009314,GO:0009628,GO:0009987,GO:0010165,GO:0010212,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0033554,GO:0034641,GO:0035312,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0045145,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360 - ko:K07462 ko03410,ko03430,ko03440,map03410,map03430,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DHH,DHHA1 k59_1515380_1 572477.Alvin_2484 5.31e-40 137.0 COG0806@1|root,COG0806@2|Bacteria,1MWQR@1224|Proteobacteria,1RNJ2@1236|Gammaproteobacteria,1WY0M@135613|Chromatiales 135613|Chromatiales J An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes rimM - - ko:K02860 - - - - ko00000,ko03009 - - - PRC,RimM k59_1515380_2 1089439.KB902271_gene1989 2.18e-33 117.0 COG0228@1|root,COG0228@2|Bacteria,1MZCT@1224|Proteobacteria,1S8RT@1236|Gammaproteobacteria,4618I@72273|Thiotrichales 72273|Thiotrichales J Belongs to the bacterial ribosomal protein bS16 family rpsP - - ko:K02959 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011,ko03029 - - - Ribosomal_S16 k59_1340277_1 1229909.NSED_02795 2.61e-42 144.0 COG0169@1|root,arCOG02097@2157|Archaea,41SKU@651137|Thaumarchaeota 651137|Thaumarchaeota E Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3- dehydroshikimate aroD - 4.2.1.10 ko:K03785 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R03084 RC00848 ko00000,ko00001,ko00002,ko01000 - - - DHquinase_I k59_1340277_2 1131266.ARWQ01000017_gene883 2.05e-32 119.0 COG0169@1|root,arCOG01033@2157|Archaea,41S6G@651137|Thaumarchaeota 651137|Thaumarchaeota E Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) aroE - 1.1.1.25 ko:K00014 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02413 RC00206 ko00000,ko00001,ko00002,ko01000 - - - Shikimate_DH,Shikimate_dh_N k59_329257_1 913325.N799_10695 7.63e-75 238.0 COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,1RMMJ@1236|Gammaproteobacteria,1X2XI@135614|Xanthomonadales 135614|Xanthomonadales I acyl-CoA dehydrogenase acdA - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_1737949_1 1122137.AQXF01000003_gene1870 7.62e-58 200.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2TQT0@28211|Alphaproteobacteria 28211|Alphaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K03296 - - - - ko00000 2.A.6.2 - - ACR_tran k59_1737949_2 1122137.AQXF01000003_gene1871 3.72e-36 134.0 COG0845@1|root,COG0845@2|Bacteria,1MV1T@1224|Proteobacteria,2VFH0@28211|Alphaproteobacteria 28211|Alphaproteobacteria M Barrel-sandwich domain of CusB or HlyD membrane-fusion - - - - - - - - - - - - HlyD_D23 k59_1572832_1 1392490.JHZX01000001_gene625 4.29e-11 66.2 COG4856@1|root,COG4856@2|Bacteria,4NHJQ@976|Bacteroidetes,1I0BY@117743|Flavobacteriia 976|Bacteroidetes S YbbR-like protein - - - - - - - - - - - - YbbR k59_900595_1 1144275.COCOR_00439 1.66e-25 108.0 COG1995@1|root,COG1995@2|Bacteria,1MX5W@1224|Proteobacteria,42NJJ@68525|delta/epsilon subdivisions,2WJGI@28221|Deltaproteobacteria,2YV17@29|Myxococcales 28221|Deltaproteobacteria C Belongs to the PdxA family pdxA - 1.1.1.262,1.1.1.408,1.1.1.409 ko:K00097,ko:K22024 ko00750,ko01100,map00750,map01100 M00124 R05681,R05837,R07406 RC00089,RC00675,RC01475 ko00000,ko00001,ko00002,ko01000 - - - PdxA k59_1409312_1 314285.KT71_01645 2.71e-46 162.0 COG2307@1|root,COG2307@2|Bacteria,1MVZK@1224|Proteobacteria,1RN2Y@1236|Gammaproteobacteria,1J8TX@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S A predicted alpha-helical domain with a conserved ER motif. - - - - - - - - - - - - Alpha-E k59_1290509_1 2340.JV46_28740 5.44e-75 251.0 COG0013@1|root,COG0013@2|Bacteria,1MU9A@1224|Proteobacteria,1RMWZ@1236|Gammaproteobacteria,1J58G@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain alaS GO:0001130,GO:0001131,GO:0001141,GO:0001217,GO:0002161,GO:0002196,GO:0003674,GO:0003700,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006355,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006450,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009451,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016070,GO:0016597,GO:0016787,GO:0016788,GO:0016874,GO:0016875,GO:0019219,GO:0019222,GO:0019538,GO:0019752,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0042802,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045934,GO:0046483,GO:0046872,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0052689,GO:0060255,GO:0065007,GO:0065008,GO:0071704,GO:0080090,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:0140110,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 6.1.1.7 ko:K01872 ko00970,map00970 M00359,M00360 R03038 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iECABU_c1320.ECABU_c29670,iECED1_1282.ECED1_3146,iEcHS_1320.EcHS_A2833,iJN746.PP_4474 DHHA1,tRNA-synt_2c,tRNA_SAD k59_1235742_2 1238450.VIBNISOn1_1840044 4.52e-29 117.0 2C4JR@1|root,325WC@2|Bacteria,1QED0@1224|Proteobacteria,1TAYY@1236|Gammaproteobacteria,1Y1E3@135623|Vibrionales 135623|Vibrionales - - - - - - - - - - - - - - - k59_1797830_1 1096930.L284_01840 1.03e-18 85.9 COG2197@1|root,COG2197@2|Bacteria 2|Bacteria K response regulator - - - ko:K02282,ko:K07782,ko:K19135 ko02020,ko02024,ko02026,map02020,map02024,map02026 - - - ko00000,ko00001,ko02035,ko02044,ko02048,ko03000 - - - Cas_NE0113,GerE,PAS_3,Response_reg,TPR_16 k59_1797834_1 246197.MXAN_0577 3.54e-24 94.4 COG3293@1|root,COG3293@2|Bacteria,1REX3@1224|Proteobacteria,433BH@68525|delta/epsilon subdivisions,2WXA2@28221|Deltaproteobacteria 1224|Proteobacteria L similarity to GB AAN56270.1 - - - - - - - - - - - - DDE_Tnp_1_2 k59_1797834_2 595460.RRSWK_01389 3.36e-23 97.1 COG0614@1|root,COG0614@2|Bacteria,2J0J0@203682|Planctomycetes 203682|Planctomycetes P PD-(D/E)XK nuclease superfamily - - - - - - - - - - - - PDDEXK_3 k59_1237010_1 1380600.AUYN01000007_gene3304 4.24e-67 218.0 COG0750@1|root,COG0750@2|Bacteria,4NEAR@976|Bacteroidetes,1HXEV@117743|Flavobacteriia 976|Bacteroidetes M zinc metalloprotease rseP - - ko:K11749 ko02024,ko04112,map02024,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - PDZ,PDZ_2,Peptidase_M50 k59_782251_1 926559.JoomaDRAFT_2666 9.89e-74 227.0 COG1051@1|root,COG1051@2|Bacteria,4NH28@976|Bacteroidetes,1HWN3@117743|Flavobacteriia 976|Bacteroidetes F Nudix hydrolase - - - - - - - - - - - - NUDIX k59_1580516_1 1051646.VITU9109_13966 3.92e-12 72.4 COG4258@1|root,COG4258@2|Bacteria,1MU1E@1224|Proteobacteria,1RMP8@1236|Gammaproteobacteria,1XU82@135623|Vibrionales 135623|Vibrionales S MMPL family VP0886 - - - - - - - - - - - MMPL k59_444584_1 1347342.BN863_1160 3.83e-98 306.0 COG0073@1|root,COG0143@1|root,COG0073@2|Bacteria,COG0143@2|Bacteria,4NECB@976|Bacteroidetes,1HXHI@117743|Flavobacteriia 976|Bacteroidetes J Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation metG GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.10 ko:K01874 ko00450,ko00970,map00450,map00970 M00359,M00360 R03659,R04773 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,tRNA-synt_1g,tRNA_bind k59_336627_1 316407.85675637 8.51e-126 384.0 COG1025@1|root,COG1025@2|Bacteria,1QTVC@1224|Proteobacteria,1T1IG@1236|Gammaproteobacteria,3XNBP@561|Escherichia 1236|Gammaproteobacteria O Endopeptidase that degrades small peptides of less than 7 kDa, such as glucagon and insulin ptrA GO:0003674,GO:0003824,GO:0004175,GO:0004222,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0008270,GO:0016787,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043167,GO:0043169,GO:0043170,GO:0044238,GO:0044424,GO:0044464,GO:0046872,GO:0046914,GO:0070011,GO:0071704,GO:0140096,GO:1901564 3.4.24.55 ko:K01407 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M16,Peptidase_M16_C,Peptidase_M16_M k59_1461586_1 1122137.AQXF01000003_gene2352 2.78e-133 392.0 COG0318@1|root,COG0318@2|Bacteria,1MUMC@1224|Proteobacteria,2TR96@28211|Alphaproteobacteria 28211|Alphaproteobacteria IQ COG0318, Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II - - 6.2.1.48 ko:K00666,ko:K02182 - - - - ko00000,ko01000,ko01004 - - - AMP-binding,AMP-binding_C k59_336646_1 158500.BV97_03275 1.5e-88 279.0 COG0145@1|root,COG0145@2|Bacteria,1MU2Y@1224|Proteobacteria,2TQZ6@28211|Alphaproteobacteria,2K20D@204457|Sphingomonadales 204457|Sphingomonadales EQ PFAM Hydantoinase oxoprolinase - - 3.5.2.14 ko:K01473 ko00330,ko01100,map00330,map01100 - R03187 RC00632 ko00000,ko00001,ko01000 - - - Hydant_A_N,Hydantoinase_A k59_1347968_1 768671.ThimaDRAFT_2665 1.44e-22 104.0 COG5473@1|root,COG5473@2|Bacteria,1R8RR@1224|Proteobacteria,1S0TC@1236|Gammaproteobacteria,1WWZI@135613|Chromatiales 135613|Chromatiales - - - - - - - - - - - - - - - k59_1122542_1 748247.AZKH_4591 5.19e-18 89.0 COG2960@1|root,COG2960@2|Bacteria 2|Bacteria M long-chain fatty acid transporting porin activity - - - ko:K07267 - - - - ko00000,ko02000 1.B.19.1 - - HXXSHH,OprB,Porin_O_P,SLH k59_952825_1 324057.Pjdr2_5752 3.1e-06 51.2 COG1334@1|root,COG1334@2|Bacteria,1TXKE@1239|Firmicutes,4HR4I@91061|Bacilli,26YZX@186822|Paenibacillaceae 91061|Bacilli N flagellar protein FlaG - - - ko:K06603 - - - - ko00000,ko02035 - - - FlaG k59_163770_1 1123075.AUDP01000026_gene421 6.2e-50 178.0 COG0404@1|root,COG0404@2|Bacteria,1TRKX@1239|Firmicutes,248U7@186801|Clostridia,3WQ35@541000|Ruminococcaceae 186801|Clostridia E The glycine cleavage system catalyzes the degradation of glycine gcvT - 2.1.2.10 ko:K00605 ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200 M00532 R01221,R02300,R04125 RC00022,RC00069,RC00183,RC02834 ko00000,ko00001,ko00002,ko01000 - - - GCV_T,GCV_T_C k59_1122545_1 935863.AWZR01000005_gene2217 5.84e-105 309.0 COG2877@1|root,COG2877@2|Bacteria,1MV91@1224|Proteobacteria,1RMGQ@1236|Gammaproteobacteria,1X45V@135614|Xanthomonadales 135614|Xanthomonadales M Belongs to the KdsA family kdsA - 2.5.1.55 ko:K01627 ko00540,ko01100,map00540,map01100 M00063 R03254 RC00435 ko00000,ko00001,ko00002,ko01000,ko01005 - - - DAHP_synth_1 k59_952828_1 1379270.AUXF01000004_gene3331 4.07e-74 248.0 COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,1ZTEZ@142182|Gemmatimonadetes 142182|Gemmatimonadetes H B12 binding domain - - 2.1.1.13 ko:K00548 ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230 M00017 R00946,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 - - - B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans k59_1688506_1 316407.85676503 9.43e-95 283.0 COG0444@1|root,COG0444@2|Bacteria,1R4KB@1224|Proteobacteria,1SMBI@1236|Gammaproteobacteria,3XM53@561|Escherichia 1236|Gammaproteobacteria EP Part of the binding-protein-dependent transport system for dipeptides. Probably responsible for energy coupling to the transport system dppD GO:0000166,GO:0003674,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008144,GO:0008150,GO:0015232,GO:0015886,GO:0016020,GO:0017076,GO:0022857,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044464,GO:0051179,GO:0051181,GO:0051184,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901678 - ko:K02031,ko:K12371,ko:K15583 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00239,M00324,M00439 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 - iECIAI1_1343.ECIAI1_1494,iSBO_1134.SBO_1821,iYL1228.KPN_03896 ABC_tran,oligo_HPY k59_1688506_2 316407.85676504 1.23e-66 210.0 COG4608@1|root,COG4608@2|Bacteria,1NU4K@1224|Proteobacteria,1SKPD@1236|Gammaproteobacteria,3XMBJ@561|Escherichia 1236|Gammaproteobacteria P Belongs to the ABC transporter superfamily dppF GO:0000166,GO:0003674,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008144,GO:0008150,GO:0009314,GO:0009628,GO:0015232,GO:0015886,GO:0016020,GO:0017076,GO:0022857,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044464,GO:0050896,GO:0051179,GO:0051181,GO:0051184,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901678 - ko:K10823,ko:K12372,ko:K19230 ko01501,ko01503,ko02010,ko02024,map01501,map01503,map02010,map02024 M00324,M00439,M00739 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25,3.A.1.5.5 - iAPECO1_1312.APECO1_362,iEC042_1314.EC042_3846,iECABU_c1320.ECABU_c39820,iECED1_1282.ECED1_4219,iECOK1_1307.ECOK1_1402,iECS88_1305.ECS88_1315,iPC815.YPO3999,iSF_1195.SF3575,iSFxv_1172.SFxv_3897,iS_1188.S4195,iUMN146_1321.UM146_10835,iUTI89_1310.UTI89_C1445,ic_1306.c4355 ABC_tran,oligo_HPY k59_1410666_2 1229780.BN381_100154 3.9e-41 154.0 COG0515@1|root,COG0515@2|Bacteria,2GJ1J@201174|Actinobacteria,3UW9J@52018|unclassified Actinobacteria (class) 201174|Actinobacteria KLT Serine threonine protein kinase - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase k59_1008202_1 159450.NH14_22140 1.2e-104 329.0 COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,2VJ57@28216|Betaproteobacteria,1K0FY@119060|Burkholderiaceae 28216|Betaproteobacteria L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity polA - 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1 k59_1181280_1 1049564.TevJSym_ba00270 4.65e-85 264.0 COG0460@1|root,COG0460@2|Bacteria,1MUDC@1224|Proteobacteria,1RPEU@1236|Gammaproteobacteria,1J4Q9@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E homoserine dehydrogenase hom - 1.1.1.3,2.7.2.4 ko:K00003,ko:K12524 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00017,M00018,M00526,M00527 R00480,R01773,R01775 RC00002,RC00043,RC00087 ko00000,ko00001,ko00002,ko01000 - - - ACT,Homoserine_dh,NAD_binding_3 k59_109410_1 935836.JAEL01000198_gene70 5.74e-32 122.0 COG2801@1|root,COG2801@2|Bacteria,1TQEG@1239|Firmicutes,4IPM1@91061|Bacilli,1ZRCB@1386|Bacillus 91061|Bacilli L DDE domain - - - - - - - - - - - - HTH_21,rve k59_1797876_1 555079.Toce_1645 2.12e-44 162.0 COG1132@1|root,COG1132@2|Bacteria,1TP0B@1239|Firmicutes,247Q0@186801|Clostridia,42F9E@68295|Thermoanaerobacterales 186801|Clostridia V ABC transporter, transmembrane region - - - ko:K18889 ko02010,map02010 M00707 - - ko00000,ko00001,ko00002,ko02000 3.A.1.106.13,3.A.1.106.5 - - ABC_membrane,ABC_tran k59_555711_1 195250.CM001776_gene3763 2.75e-81 249.0 COG1741@1|root,COG1741@2|Bacteria,1G0UH@1117|Cyanobacteria,1GYC7@1129|Synechococcus 1117|Cyanobacteria S Belongs to the pirin family - - - ko:K06911 - - - - ko00000 - - - Pirin k59_555711_2 1123072.AUDH01000004_gene576 1.63e-19 85.9 COG3613@1|root,COG3613@2|Bacteria,1N0AK@1224|Proteobacteria,2UCQW@28211|Alphaproteobacteria,2JTP6@204441|Rhodospirillales 204441|Rhodospirillales F Nucleoside 2-deoxyribosyltransferase - - - - - - - - - - - - Nuc_deoxyrib_tr k59_279001_6 1235835.C814_00380 3.76e-13 73.2 2C0VP@1|root,30UHN@2|Bacteria,1W13S@1239|Firmicutes,253W8@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - k59_279001_13 323259.Mhun_0724 2.94e-22 97.1 arCOG07591@1|root,arCOG07591@2157|Archaea,2XX06@28890|Euryarchaeota 28890|Euryarchaeota S von Willebrand factor (vWF) type A domain - - - - - - - - - - - - VWA,VWA_2 k59_279001_19 323098.Nwi_1480 3.72e-24 96.3 COG1403@1|root,COG1403@2|Bacteria,1N7SV@1224|Proteobacteria,2UDBS@28211|Alphaproteobacteria 28211|Alphaproteobacteria L endonuclease - - - - - - - - - - - - HNH k59_1181292_1 1088721.NSU_2343 1.71e-180 514.0 COG0459@1|root,COG0459@2|Bacteria,1MURR@1224|Proteobacteria,2TS07@28211|Alphaproteobacteria,2K33P@204457|Sphingomonadales 204457|Sphingomonadales O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions - - - ko:K04077 ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 - - - Cpn60_TCP1 k59_1461619_2 436308.Nmar_0443 1.19e-193 541.0 COG1146@1|root,arCOG04548@2157|Archaea,41SH5@651137|Thaumarchaeota 651137|Thaumarchaeota C ferredoxin - - - - - - - - - - - - Fer4 k59_1069585_1 323259.Mhun_3126 9.89e-06 55.8 arCOG02516@1|root,arCOG03509@1|root,arCOG02516@2157|Archaea,arCOG03509@2157|Archaea 2157|Archaea S Domain of unknown function (DUF2341) - - - - - - - - - - - - Big_5,CHB_HEX_C_1,DUF2341,PEGA,PKD,PQQ_3 k59_336672_1 1122137.AQXF01000001_gene3348 5.59e-120 345.0 COG0131@1|root,COG0131@2|Bacteria,1MWBS@1224|Proteobacteria,2TTVV@28211|Alphaproteobacteria 28211|Alphaproteobacteria E imidazoleglycerol-phosphate dehydratase hisB GO:0000105,GO:0003674,GO:0003824,GO:0004424,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.6.1.9,3.1.3.15,4.2.1.19 ko:K00817,ko:K01089,ko:K01693 ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230 M00026 R00694,R00734,R03013,R03243,R03457 RC00006,RC00017,RC00888,RC00932 ko00000,ko00001,ko00002,ko01000,ko01007 - - - IGPD k59_336672_2 1122137.AQXF01000001_gene3347 2.62e-15 72.8 COG0118@1|root,COG0118@2|Bacteria,1MU4X@1224|Proteobacteria,2TTT4@28211|Alphaproteobacteria 28211|Alphaproteobacteria E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR hisH - - ko:K02501 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04558 RC00010,RC01190,RC01943 ko00000,ko00001,ko00002,ko01000 - - - GATase k59_1410689_1 384676.PSEEN3230 1.08e-37 145.0 COG1020@1|root,COG1020@2|Bacteria,1QK4F@1224|Proteobacteria,1RPAG@1236|Gammaproteobacteria 1236|Gammaproteobacteria Q COG1020 Non-ribosomal peptide synthetase modules and related proteins - - - - - - - - - - - - AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase k59_1069592_1 1565129.JSFF01000006_gene2557 6.73e-14 71.2 COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,1RMQ4@1236|Gammaproteobacteria,2QAZB@267890|Shewanellaceae 1236|Gammaproteobacteria IQ PFAM AMP-dependent synthetase and ligase caiC GO:0003674,GO:0003824,GO:0016405,GO:0016874,GO:0016877,GO:0016879,GO:0016881,GO:0051108,GO:0051109 6.2.1.48 ko:K02182 - - - - ko00000,ko01000 - - iECSE_1348.ECSE_0038,iNRG857_1313.NRG857_00195 AMP-binding,AMP-binding_C k59_1633330_1 883080.HMPREF9697_01860 6.5e-25 105.0 COG1802@1|root,COG1802@2|Bacteria,1N7GE@1224|Proteobacteria,2TRBH@28211|Alphaproteobacteria,3JUUF@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria K FCD - - - ko:K11475 - - - - ko00000,ko03000 - - - FCD,GntR k59_1633330_2 59538.XP_005980145.1 6.49e-32 122.0 COG1804@1|root,KOG3957@2759|Eukaryota,38CWZ@33154|Opisthokonta,3BB7M@33208|Metazoa,3D0JC@33213|Bilateria,4838Z@7711|Chordata,48ZTZ@7742|Vertebrata,3JBNC@40674|Mammalia 33208|Metazoa I succinate-hydroxymethylglutarate CoA-transferase activity - - - - - - - - - - - iEC55989_1330.EC55989_0038,iECIAI1_1343.ECIAI1_0040,iECO103_1326.ECO103_0040,iECO111_1330.ECO111_0039,iECO26_1355.ECO26_0039,iEcHS_1320.EcHS_A0042,iSF_1195.SF0035,iSFxv_1172.SFxv_0036,iS_1188.S0037 CoA_transf_3 k59_53440_1 338969.Rfer_0960 2.28e-30 120.0 COG0477@1|root,COG2814@2|Bacteria,1R3WC@1224|Proteobacteria,2VKT9@28216|Betaproteobacteria 28216|Betaproteobacteria EGP major facilitator superfamily - - - - - - - - - - - - MFS_1 k59_670834_1 316407.85676529 2.98e-136 387.0 COG2207@1|root,COG2207@2|Bacteria,1QIIZ@1224|Proteobacteria,1TGDT@1236|Gammaproteobacteria,3XQQ1@561|Escherichia 1236|Gammaproteobacteria K Depending on the conditions (growth phase and medium), acts as a positive or negative regulator of gadA and gadBC. Repression occurs directly or via the repression of the expression of gadX. Activation occurs directly by the binding of GadW to the gadA and gadBC promoters gadW GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0005488,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031326,GO:0032774,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0051716,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1903506,GO:2000112,GO:2001141 - ko:K21906 - - - - ko00000,ko03000 - - - HTH_18 k59_1580556_1 1229909.NSED_07800 4.08e-08 53.1 arCOG08772@1|root,arCOG08772@2157|Archaea,41SSX@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1580556_2 1229909.NSED_07795 1.47e-207 577.0 COG0104@1|root,arCOG04387@2157|Archaea,41SCA@651137|Thaumarchaeota 651137|Thaumarchaeota F Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP purA - 6.3.4.4 ko:K01939 ko00230,ko00250,ko01100,map00230,map00250,map01100 M00049 R01135 RC00458,RC00459 ko00000,ko00001,ko00002,ko01000 - - - Adenylsucc_synt k59_444642_1 1123517.JOMR01000001_gene955 4.74e-233 670.0 COG0610@1|root,COG0610@2|Bacteria,1MU96@1224|Proteobacteria,1RP2Q@1236|Gammaproteobacteria,46087@72273|Thiotrichales 72273|Thiotrichales L Subunit R is required for both nuclease and ATPase activities, but not for modification - - 3.1.21.3 ko:K01153 - - - - ko00000,ko01000,ko02048 - - - EcoR124_C,HSDR_N,ResIII k59_279037_1 266117.Rxyl_0021 4.78e-26 111.0 COG0515@1|root,COG2815@1|root,COG0515@2|Bacteria,COG2815@2|Bacteria,2GJ1J@201174|Actinobacteria,4CPU4@84995|Rubrobacteria 84995|Rubrobacteria KLT Serine threonine protein kinase - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - PASTA,Pkinase k59_1688552_1 1380390.JIAT01000009_gene2005 8.99e-23 99.8 COG2047@1|root,COG2047@2|Bacteria,2I2H9@201174|Actinobacteria,4CP8R@84995|Rubrobacteria 84995|Rubrobacteria S PAC2 family - - - - - - - - - - - - PAC2 k59_1069604_1 1122137.AQXF01000002_gene129 2.79e-39 142.0 COG0442@1|root,COG0442@2|Bacteria,1MU7E@1224|Proteobacteria,2TQQ4@28211|Alphaproteobacteria 28211|Alphaproteobacteria J Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) proS GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 6.1.1.15 ko:K01881 ko00970,map00970 M00359,M00360 R03661 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,tRNA-synt_2b k59_1069604_2 1122137.AQXF01000002_gene130 1.79e-32 123.0 COG4591@1|root,COG4591@2|Bacteria,1MVV7@1224|Proteobacteria,2TRBX@28211|Alphaproteobacteria 28211|Alphaproteobacteria M lipoprotein releasing system, transmembrane protein, LolC E family' lolC - - ko:K09808 ko02010,map02010 M00255 - - ko00000,ko00001,ko00002,ko02000 3.A.1.125 - - FtsX,MacB_PCD k59_901986_1 1123236.KB899383_gene2647 5.93e-97 292.0 COG3507@1|root,COG3507@2|Bacteria,1R3V6@1224|Proteobacteria,1RPI5@1236|Gammaproteobacteria,465M3@72275|Alteromonadaceae 1236|Gammaproteobacteria G Glycosyl hydrolases family 43 abnA - 3.2.1.99 ko:K06113 - - - - ko00000,ko01000 - GH43 - Glyco_hydro_43 k59_1522981_1 1122137.AQXF01000006_gene753 7.12e-119 356.0 COG1757@1|root,COG1757@2|Bacteria,1MY5C@1224|Proteobacteria,2VG60@28211|Alphaproteobacteria 28211|Alphaproteobacteria C COG1757 Na H antiporter - - - - - - - - - - - - Na_H_antiporter k59_1522993_1 717605.Theco_3862 1.25e-13 72.0 COG0712@1|root,COG0712@2|Bacteria,1VAG3@1239|Firmicutes,4HKFW@91061|Bacilli,26UM4@186822|Paenibacillaceae 91061|Bacilli C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation atpH - - ko:K02113 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - OSCP k59_53460_1 1499967.BAYZ01000080_gene928 8.5e-31 125.0 COG3420@1|root,COG3420@2|Bacteria,2NRSC@2323|unclassified Bacteria 2|Bacteria P alginic acid biosynthetic process - - 4.2.2.3 ko:K01729 ko00051,map00051 - R03706 - ko00000,ko00001,ko01000 - - - Beta_helix,Chondroitinas_B k59_670865_1 522306.CAP2UW1_3009 8.3e-06 47.8 COG0741@1|root,COG0741@2|Bacteria,1R666@1224|Proteobacteria,2VHI4@28216|Betaproteobacteria 28216|Betaproteobacteria M PFAM Lytic transglycosylase catalytic - - - - - - - - - - - - SLT k59_670865_2 582744.Msip34_2279 2.1e-36 137.0 COG0442@1|root,COG0442@2|Bacteria,1MU7E@1224|Proteobacteria,2VGZ9@28216|Betaproteobacteria,2KKEY@206350|Nitrosomonadales 206350|Nitrosomonadales J Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS proS - 6.1.1.15 ko:K01881 ko00970,map00970 M00359,M00360 R03661 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,tRNA-synt_2b,tRNA_edit k59_220990_1 1168067.JAGP01000001_gene191 2.36e-21 94.4 COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,1RNJI@1236|Gammaproteobacteria,4603G@72273|Thiotrichales 72273|Thiotrichales L it can initiate unwinding at a nick in the DNA. It binds to the single-stranded DNA and acts in a progressive fashion along the DNA in the 3' to 5' direction rep - 3.6.4.12 ko:K03656 - - - - ko00000,ko01000,ko03400 - - - UvrD-helicase,UvrD_C k59_220990_2 1175306.GWL_45390 2.18e-14 70.9 COG3023@1|root,COG3023@2|Bacteria,1RDHU@1224|Proteobacteria,2VR5A@28216|Betaproteobacteria,4747Y@75682|Oxalobacteraceae 28216|Betaproteobacteria V Ami_2 ampD GO:0000270,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0006022,GO:0006026,GO:0006027,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008745,GO:0009056,GO:0009057,GO:0009253,GO:0009254,GO:0009392,GO:0016020,GO:0016787,GO:0016810,GO:0016811,GO:0019867,GO:0030203,GO:0043167,GO:0043169,GO:0043170,GO:0046872,GO:0046914,GO:0061783,GO:0071704,GO:1901135,GO:1901136,GO:1901564,GO:1901565,GO:1901575 3.5.1.28 ko:K03806 - - - - ko00000,ko01000,ko01011 - - - Amidase_2 k59_1797940_1 1046627.BZARG_2051 6.66e-07 57.8 COG5263@1|root,COG5263@2|Bacteria,4NJ6B@976|Bacteroidetes,1HX7Q@117743|Flavobacteriia 976|Bacteroidetes KT PFAM KWG Leptospira - - - - - - - - - - - - WG_beta_rep k59_1797940_2 1484460.JSWG01000010_gene3215 0.000201 42.7 COG2986@1|root,COG2986@2|Bacteria,4NE0D@976|Bacteroidetes,1HX2V@117743|Flavobacteriia 976|Bacteroidetes E Histidine ammonia-lyase hutH - 4.3.1.23,4.3.1.3 ko:K01745,ko:K10774 ko00340,ko00350,ko01100,map00340,map00350,map01100 M00045 R00737,R01168 RC00361 ko00000,ko00001,ko00002,ko01000 - - - Lyase_aromatic k59_163846_2 1122137.AQXF01000005_gene1124 2.43e-79 247.0 COG0404@1|root,COG0404@2|Bacteria,1MV96@1224|Proteobacteria,2TRN4@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Glycine cleavage system T protein gcvT GO:0001505,GO:0003674,GO:0003824,GO:0004047,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005960,GO:0006082,GO:0006520,GO:0006544,GO:0006546,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008483,GO:0009056,GO:0009063,GO:0009069,GO:0009071,GO:0009987,GO:0016054,GO:0016740,GO:0016741,GO:0016769,GO:0017144,GO:0019464,GO:0019752,GO:0032259,GO:0032991,GO:0042133,GO:0042135,GO:0042737,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0065007,GO:0065008,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606,GO:1902494,GO:1990204 2.1.2.10 ko:K00605 ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200 M00532 R01221,R02300,R04125 RC00022,RC00069,RC00183,RC02834 ko00000,ko00001,ko00002,ko01000 - - - GCV_T,GCV_T_C k59_1688575_1 1042375.AFPL01000055_gene2255 3.44e-14 75.1 COG1305@1|root,COG1305@2|Bacteria,1MWCE@1224|Proteobacteria,1RPH9@1236|Gammaproteobacteria,464NQ@72275|Alteromonadaceae 1236|Gammaproteobacteria E COG1305 Transglutaminase-like enzymes tgpA - 2.3.2.13 ko:K22452 - - - - ko00000,ko01000 - - - DUF3488,DUF4129,Transglut_core k59_1688575_2 314285.KT71_14824 1.1e-50 174.0 COG1721@1|root,COG1721@2|Bacteria,1R3QD@1224|Proteobacteria,1S5F7@1236|Gammaproteobacteria,1J60U@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S conserved protein (some members contain a von Willebrand factor type A (vWA) domain) - - - - - - - - - - - - DUF58 k59_1008259_1 426355.Mrad2831_0630 1.15e-50 177.0 COG0165@1|root,COG0165@2|Bacteria,1MX0X@1224|Proteobacteria,2V9K5@28211|Alphaproteobacteria,1JT63@119045|Methylobacteriaceae 28211|Alphaproteobacteria M Argininosuccinate lyase C-terminal - - 4.3.2.1 ko:K01755 ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230 M00029,M00844,M00845 R01086 RC00445,RC00447 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ASL_C2,Lyase_1 k59_1291965_1 342113.DM82_4330 3.7e-16 82.0 COG1556@1|root,COG1556@2|Bacteria,1R4TE@1224|Proteobacteria,2VJCF@28216|Betaproteobacteria,1K1I9@119060|Burkholderiaceae 28216|Betaproteobacteria S LUD domain - - - ko:K00782 - - - - ko00000 - - - LUD_dom k59_1461693_1 887062.HGR_05419 9.24e-128 374.0 COG2230@1|root,COG2230@2|Bacteria,1MUW5@1224|Proteobacteria,2VI5F@28216|Betaproteobacteria,4ACT9@80864|Comamonadaceae 28216|Betaproteobacteria M Mycolic acid cyclopropane synthetase - - 2.1.1.79 ko:K00574 - - - - ko00000,ko01000 - - - CMAS k59_1461704_1 1123321.KB905816_gene2669 5.34e-05 49.7 COG1309@1|root,COG1309@2|Bacteria,2IE7N@201174|Actinobacteria 201174|Actinobacteria K Bacterial transcriptional repressor C-terminal - - - - - - - - - - - - TetR_C_11,TetR_N k59_1523022_1 1042375.AFPL01000032_gene936 3.84e-44 158.0 COG0733@1|root,COG0733@2|Bacteria,1MUZJ@1224|Proteobacteria,1RPCT@1236|Gammaproteobacteria,464UT@72275|Alteromonadaceae 1236|Gammaproteobacteria S COG0733 Na -dependent transporters of the SNF family - - - ko:K03308 - - - - ko00000 2.A.22.4,2.A.22.5 - - SNF k59_1137718_1 1227454.C446_16500 2.62e-10 67.4 COG1053@1|root,arCOG00571@2157|Archaea,2XTK0@28890|Euryarchaeota,23TAU@183963|Halobacteria 183963|Halobacteria C COG1053 Succinate dehydrogenase fumarate reductase, flavoprotein subunit - - 1.3.5.1,1.3.5.4 ko:K00239 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134 M00009,M00011,M00149,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,Succ_DH_flav_C k59_912103_3 1034769.KB910518_gene1204 2.96e-97 295.0 COG0444@1|root,COG0444@2|Bacteria,1TP6E@1239|Firmicutes,4HA4E@91061|Bacilli,26QZ3@186822|Paenibacillaceae 91061|Bacilli P Belongs to the ABC transporter superfamily - - - ko:K02031 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - ABC_tran,oligo_HPY k59_65119_1 640081.Dsui_1434 9.59e-63 204.0 COG1352@1|root,COG1352@2|Bacteria,1MU6W@1224|Proteobacteria,2VMPX@28216|Betaproteobacteria,2KUUF@206389|Rhodocyclales 206389|Rhodocyclales H Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP - - 2.1.1.80 ko:K00575 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko01000,ko02035 - - - CheR,CheR_N k59_1477306_1 1123253.AUBD01000001_gene1663 1.84e-77 260.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1X3PQ@135614|Xanthomonadales 135614|Xanthomonadales V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family mdtB - - ko:K03296 - - - - ko00000 2.A.6.2 - - ACR_tran k59_1364129_1 454957.IA64_16030 7.43e-58 196.0 COG2272@1|root,COG2272@2|Bacteria,1MVQZ@1224|Proteobacteria,1RPFW@1236|Gammaproteobacteria,1X4EB@135614|Xanthomonadales 135614|Xanthomonadales I Belongs to the type-B carboxylesterase lipase family - - - ko:K03929 - - - - ko00000,ko01000 - CE10 - COesterase k59_291035_1 1144305.PMI02_02734 2e-129 390.0 COG4772@1|root,COG4772@2|Bacteria,1MVMV@1224|Proteobacteria,2U54Y@28211|Alphaproteobacteria,2K2W2@204457|Sphingomonadales 204457|Sphingomonadales P TonB-dependent receptor plug - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_233794_1 768671.ThimaDRAFT_1699 1.14e-19 95.1 COG0642@1|root,COG3614@1|root,COG5002@1|root,COG0642@2|Bacteria,COG3614@2|Bacteria,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,1T1JE@1236|Gammaproteobacteria,1WXBB@135613|Chromatiales 135613|Chromatiales T response regulator receiver - - - - - - - - - - - - CHASE,HATPase_c,HisKA,PAS_8,Response_reg k59_1702571_1 1492737.FEM08_19370 1.36e-10 60.5 COG1834@1|root,COG1834@2|Bacteria,4NEUJ@976|Bacteroidetes,1HWNG@117743|Flavobacteriia,2NTBC@237|Flavobacterium 976|Bacteroidetes E Cytochrome C biogenesis protein CcmF - - - - - - - - - - - - Amidinotransf k59_1702571_2 391603.FBALC1_13277 5.9e-172 488.0 COG0372@1|root,COG0372@2|Bacteria,4NFXK@976|Bacteroidetes,1HWVX@117743|Flavobacteriia 976|Bacteroidetes C Belongs to the citrate synthase family gltA - 2.3.3.1 ko:K01647 ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00740 R00351 RC00004,RC00067 br01601,ko00000,ko00001,ko00002,ko01000 - - - Citrate_synt k59_572763_2 287986.DV20_31665 1.52e-55 187.0 COG0483@1|root,COG0483@2|Bacteria,2GKZZ@201174|Actinobacteria,4DY3G@85010|Pseudonocardiales 201174|Actinobacteria G TIGRFAM histidinol-phosphate phosphatase HisN, inositol monophosphatase family hisN - 3.1.3.15,3.1.3.25 ko:K01092,ko:K05602 ko00340,ko00521,ko00562,ko01100,ko01110,ko01230,ko04070,map00340,map00521,map00562,map01100,map01110,map01230,map04070 M00026,M00131 R01185,R01186,R01187,R03013 RC00017,RC00078 ko00000,ko00001,ko00002,ko01000 - - - Inositol_P k59_1420039_1 1229909.NSED_00085 5.45e-93 276.0 COG2109@1|root,arCOG04678@2157|Archaea,41SFP@651137|Thaumarchaeota 651137|Thaumarchaeota H ATP corrinoid adenosyltransferase - - 2.5.1.17 ko:K19221 ko00860,ko01100,map00860,map01100 M00122 R01492,R05220,R07268 RC00533 ko00000,ko00001,ko00002,ko01000 - - - CobA_CobO_BtuR k59_233800_1 314230.DSM3645_14935 8.66e-94 285.0 COG4948@1|root,COG4948@2|Bacteria,2IY40@203682|Planctomycetes 203682|Planctomycetes M Mandelate racemase muconate lactonizing enzyme - - 4.2.1.6 ko:K01684 ko00052,ko01100,ko01120,map00052,map01100,map01120 M00552 R03033 RC00543 ko00000,ko00001,ko00002,ko01000 - - - MR_MLE_C,MR_MLE_N k59_1759304_1 1046714.AMRX01000006_gene2838 7.94e-69 221.0 COG3004@1|root,COG3004@2|Bacteria,1MW15@1224|Proteobacteria,1RNDE@1236|Gammaproteobacteria,465KF@72275|Alteromonadaceae 1236|Gammaproteobacteria P Na( ) H( ) antiporter that extrudes sodium in exchange for external protons nhaA - - ko:K03313 - - - - ko00000,ko02000 2.A.33.1 - - Na_H_antiport_1 k59_1589542_1 1122137.AQXF01000005_gene1365 6.26e-18 79.3 COG3751@1|root,COG3751@2|Bacteria,1NG7K@1224|Proteobacteria,2VG2X@28211|Alphaproteobacteria 28211|Alphaproteobacteria O Prolyl 4-hydroxylase alpha subunit homologues. - - 1.14.11.2 ko:K00472 ko00330,ko01100,map00330,map01100 - R01252 RC00478 ko00000,ko00001,ko01000 - - - 2OG-FeII_Oxy_3 k59_1589542_2 1122137.AQXF01000005_gene1366 3.85e-230 643.0 COG0166@1|root,COG0166@2|Bacteria,1MUFP@1224|Proteobacteria,2TQKP@28211|Alphaproteobacteria 28211|Alphaproteobacteria G Belongs to the GPI family pgi GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.2.1.2,5.3.1.9 ko:K01810,ko:K13810 ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00004,M00007,M00114 R01827,R02739,R02740,R03321 RC00376,RC00439,RC00563,RC00604 ko00000,ko00001,ko00002,ko01000,ko04147 - - - PGI,TAL_FSA k59_1589542_3 290633.GOX0044 4.34e-17 80.1 COG1109@1|root,COG1210@1|root,COG1109@2|Bacteria,COG1210@2|Bacteria,1MUA5@1224|Proteobacteria,2TRIJ@28211|Alphaproteobacteria,2JQBM@204441|Rhodospirillales 204441|Rhodospirillales G phosphomannomutase exoC - 5.4.2.8 ko:K01840 ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130 M00114 R01818 RC00408 ko00000,ko00001,ko00002,ko01000 - - - PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV k59_1025712_1 1123504.JQKD01000002_gene3936 0.000107 45.1 COG1062@1|root,COG1062@2|Bacteria,1MUK4@1224|Proteobacteria,2VIJB@28216|Betaproteobacteria,4AAD5@80864|Comamonadaceae 1123504.JQKD01000002_gene3936|- C Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily - - - - - - - - - - - - - k59_1025712_2 1205680.CAKO01000029_gene5263 1.54e-26 103.0 COG1028@1|root,COG1028@2|Bacteria,1MXFZ@1224|Proteobacteria,2TQZ9@28211|Alphaproteobacteria,2JRAG@204441|Rhodospirillales 204441|Rhodospirillales IQ COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - 1.1.1.100 ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 k59_855957_1 391589.RGAI101_553 1.02e-49 163.0 2B1WH@1|root,30C4Q@2|Bacteria,1R3E9@1224|Proteobacteria,2U7UN@28211|Alphaproteobacteria 28211|Alphaproteobacteria S MAPEG family - - - - - - - - - - - - MAPEG k59_291094_2 158500.BV97_00533 3.13e-71 226.0 COG0457@1|root,COG0457@2|Bacteria,1NU2Z@1224|Proteobacteria,2UP5I@28211|Alphaproteobacteria,2K8VY@204457|Sphingomonadales 204457|Sphingomonadales S Sulfotransferase domain - - - - - - - - - - - - Sulfotransfer_3 k59_8515_1 439235.Dalk_5087 3.76e-109 328.0 COG3385@1|root,COG3385@2|Bacteria,1PMXF@1224|Proteobacteria,43B8Z@68525|delta/epsilon subdivisions,2X6NB@28221|Deltaproteobacteria,2MPI8@213118|Desulfobacterales 1224|Proteobacteria L PFAM transposase IS4 family protein - - - - - - - - - - - - DDE_Tnp_1,DUF4372 k59_1025732_1 1042377.AFPJ01000024_gene709 1.97e-55 190.0 COG0651@1|root,COG0651@2|Bacteria,1MV6V@1224|Proteobacteria,1RQK5@1236|Gammaproteobacteria,464XB@72275|Alteromonadaceae 1236|Gammaproteobacteria CP Proton-conducting membrane transporter - - - ko:K05568 - - - - ko00000,ko02000 2.A.63.1,2.A.63.2 - - Proton_antipo_M k59_8519_2 1168059.KB899087_gene3798 2.53e-06 48.9 COG0310@1|root,COG0310@2|Bacteria,1MXW7@1224|Proteobacteria,2TT6R@28211|Alphaproteobacteria,3F0HF@335928|Xanthobacteraceae 28211|Alphaproteobacteria P Cobalt uptake substrate-specific transmembrane region MA20_14475 - - - - - - - - - - - CbiM k59_1533605_1 1229909.NSED_08780 9.96e-213 590.0 COG0604@1|root,arCOG01458@2157|Archaea,41SZ9@651137|Thaumarchaeota 651137|Thaumarchaeota C PFAM Alcohol dehydrogenase GroES-like domain - - - - - - - - - - - - ADH_N,ADH_zinc_N k59_629402_1 743721.Psesu_1431 0.000495 44.3 COG3040@1|root,COG3040@2|Bacteria 2|Bacteria M lipid binding blc - - ko:K03098 - - - - ko00000,ko04147 - - - Lipocalin_2 k59_799674_2 1201293.AKXQ01000023_gene4203 7.7e-60 196.0 COG3004@1|root,COG3004@2|Bacteria,1MW15@1224|Proteobacteria,1RNDE@1236|Gammaproteobacteria 1236|Gammaproteobacteria P Na( ) H( ) antiporter that extrudes sodium in exchange for external protons nhaA - - ko:K03313 - - - - ko00000,ko02000 2.A.33.1 - - Na_H_antiport_1 k59_1025738_1 648757.Rvan_0035 2.78e-178 504.0 COG1024@1|root,COG1024@2|Bacteria,1QY95@1224|Proteobacteria,2U4PY@28211|Alphaproteobacteria 28211|Alphaproteobacteria I Enoyl-CoA hydratase/isomerase - - 3.7.1.21 ko:K07539 ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220 M00541 R05593,R05594,R10696 RC01430,RC01431,RC03237 ko00000,ko00001,ko00002,ko01000 - - - ECH_1 k59_1025738_2 1244869.H261_10432 4.24e-05 44.7 COG1064@1|root,COG1064@2|Bacteria,1MUTT@1224|Proteobacteria,2TTYY@28211|Alphaproteobacteria,2JRF3@204441|Rhodospirillales 204441|Rhodospirillales S alcohol dehydrogenase - - - ko:K18382 ko00640,map00640 - R10703 RC00545 ko00000,ko00001,ko01000 - - - ADH_N,ADH_zinc_N k59_347551_1 269800.Tfu_0620 4.75e-93 289.0 COG5297@1|root,COG5297@2|Bacteria,2GK92@201174|Actinobacteria,4EFJ7@85012|Streptosporangiales 201174|Actinobacteria G Glycosyl hydrolases family 6 - - 3.2.1.91 ko:K19668 ko00500,ko01100,ko02020,map00500,map01100,map02020 - R02886,R11308 RC00799 ko00000,ko00001,ko01000 - GH6 - CBM_2,Glyco_hydro_6 k59_1137836_1 1453496.AT03_05410 5.38e-05 48.5 COG2976@1|root,COG2976@2|Bacteria,1N117@1224|Proteobacteria,1S95P@1236|Gammaproteobacteria 1236|Gammaproteobacteria S protein conserved in bacteria yfgM GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0009897,GO:0009986,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0031233,GO:0044425,GO:0044459,GO:0044464,GO:0071575,GO:0071944,GO:0098552 - - - - - - - - - - TPR_21 k59_8534_1 316407.85675766 1.32e-141 405.0 28JQ2@1|root,2Z9G0@2|Bacteria,1R82P@1224|Proteobacteria,1RRVP@1236|Gammaproteobacteria,3XP2M@561|Escherichia 1236|Gammaproteobacteria S Protein of unknown function (DUF1202) yggM - - - - - - - - - - - DUF1202 k59_1025753_1 1088721.NSU_0180 3.73e-65 221.0 COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,2TWGU@28211|Alphaproteobacteria,2KEQG@204457|Sphingomonadales 204457|Sphingomonadales C Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain - - - - - - - - - - - - Ald_Xan_dh_C,Ald_Xan_dh_C2 k59_968283_1 402626.Rpic_3304 1.57e-42 150.0 COG0583@1|root,COG0583@2|Bacteria,1MW16@1224|Proteobacteria,2VQR6@28216|Betaproteobacteria,1K0MB@119060|Burkholderiaceae 28216|Betaproteobacteria K Transcriptional regulator - - - - - - - - - - - - HTH_1,LysR_substrate k59_912156_2 415426.Hbut_1010 5e-09 59.7 COG0330@1|root,arCOG01915@2157|Archaea,2XPQN@28889|Crenarchaeota 28889|Crenarchaeota O PFAM band 7 protein - - - - - - - - - - - - Band_7 k59_1533630_1 398767.Glov_3575 8.72e-35 130.0 COG1300@1|root,COG1300@2|Bacteria,1Q1GN@1224|Proteobacteria,42UUJ@68525|delta/epsilon subdivisions,2WQQ0@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Stage II sporulation protein M - - - - - - - - - - - - SpoIIM k59_1533630_2 590998.Celf_2478 4.5e-07 56.6 COG1721@1|root,COG1721@2|Bacteria,2GK9A@201174|Actinobacteria,4F118@85016|Cellulomonadaceae 201174|Actinobacteria S Protein of unknown function DUF58 - - - - - - - - - - - - DUF11,DUF58 k59_1589577_1 1229909.NSED_04500 4.13e-49 159.0 COG2090@1|root,arCOG04171@2157|Archaea,41SNF@651137|Thaumarchaeota 651137|Thaumarchaeota S Domain of unknown function (DUF371) - - - ko:K09738 - - - - ko00000 - - - DUF371 k59_459982_2 264198.Reut_A2099 1.46e-19 89.4 COG0604@1|root,COG0604@2|Bacteria,1MWRK@1224|Proteobacteria,2VJ1C@28216|Betaproteobacteria,1K27J@119060|Burkholderiaceae 28216|Betaproteobacteria C PFAM Alcohol dehydrogenase zinc-binding domain protein - - 1.6.5.5 ko:K00344 - - - - ko00000,ko01000 - - - ADH_N,ADH_zinc_N k59_1533634_1 207559.Dde_3692 9.1e-15 76.6 COG0110@1|root,COG0110@2|Bacteria,1MUCJ@1224|Proteobacteria,42VP2@68525|delta/epsilon subdivisions,2WRZQ@28221|Deltaproteobacteria,2MG3Y@213115|Desulfovibrionales 28221|Deltaproteobacteria S TIGRFAM phosphonate metabolim protein, transferase hexapeptide repeat family - - - - - - - - - - - - Hexapep k59_629420_1 1031711.RSPO_c02692 2.25e-49 173.0 COG0540@1|root,COG0540@2|Bacteria,1MWAB@1224|Proteobacteria,2VHG9@28216|Betaproteobacteria,1JZN1@119060|Burkholderiaceae 28216|Betaproteobacteria F Belongs to the ATCase OTCase family pyrB - 2.1.3.2 ko:K00609 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R01397 RC00064,RC02850 ko00000,ko00001,ko00002,ko01000 - - - OTCace,OTCace_N k59_1533635_1 1279017.AQYJ01000028_gene2318 1.01e-45 154.0 COG0846@1|root,COG0846@2|Bacteria,1MUK1@1224|Proteobacteria,1RMX5@1236|Gammaproteobacteria,4659I@72275|Alteromonadaceae 1236|Gammaproteobacteria K NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form cobB GO:0002252,GO:0002376,GO:0003674,GO:0003824,GO:0006464,GO:0006476,GO:0006807,GO:0006935,GO:0006950,GO:0006952,GO:0008150,GO:0008152,GO:0009605,GO:0009607,GO:0009615,GO:0009987,GO:0016787,GO:0016810,GO:0016811,GO:0018193,GO:0018205,GO:0019213,GO:0019538,GO:0033558,GO:0034979,GO:0034983,GO:0035601,GO:0036048,GO:0036049,GO:0036055,GO:0036211,GO:0040011,GO:0042221,GO:0042330,GO:0043170,GO:0043207,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0050896,GO:0051607,GO:0051704,GO:0051707,GO:0071704,GO:0098542,GO:0098732,GO:0140096,GO:1901564 - ko:K12410 - - - - ko00000,ko01000 - - - SIR2 k59_1533635_2 1415778.JQMM01000001_gene2109 6.37e-22 94.7 COG0826@1|root,COG0826@2|Bacteria,1MUQG@1224|Proteobacteria,1RNPY@1236|Gammaproteobacteria,1J58A@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O COG0826 Collagenase and related proteases yegQ GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - ko:K08303 ko05120,map05120 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_U32,Peptidase_U32_C k59_121443_2 1189612.A33Q_0543 5.36e-06 52.0 COG1595@1|root,COG1595@2|Bacteria,4NIRG@976|Bacteroidetes,47TSQ@768503|Cytophagia 976|Bacteroidetes K ECF sigma factor - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 k59_685727_1 1123020.AUIE01000012_gene75 1.61e-15 78.6 COG2885@1|root,COG2885@2|Bacteria,1RGHU@1224|Proteobacteria,1S5H8@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Belongs to the ompA family - - - ko:K03286 - - - - ko00000,ko02000 1.B.6 - - OmpA,TSP_3 k59_459994_1 525904.Tter_0001 1.02e-08 55.8 COG0593@1|root,COG0593@2|Bacteria,2NNTK@2323|unclassified Bacteria 2|Bacteria L it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids dnaA GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003688,GO:0003690,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006172,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009133,GO:0009135,GO:0009136,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009179,GO:0009180,GO:0009185,GO:0009188,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016311,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030312,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046031,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090304,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990837 - ko:K02313 ko02020,ko04112,map02020,map04112 - - - ko00000,ko00001,ko03032,ko03036 - - - Bac_DnaA,Bac_DnaA_C,DnaA_N k59_1081530_1 95619.PM1_0201870 3.98e-53 174.0 COG0219@1|root,COG0219@2|Bacteria,1RCY4@1224|Proteobacteria,1S3PI@1236|Gammaproteobacteria 1236|Gammaproteobacteria J Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide trmL GO:0001510,GO:0002128,GO:0002130,GO:0002131,GO:0002132,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016300,GO:0016427,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042802,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0052665,GO:0052666,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.1.1.207 ko:K03216 - - - - ko00000,ko01000,ko03016 - - - SpoU_methylase k59_969195_2 1286170.RORB6_03970 7.85e-07 49.7 COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,1RNJ1@1236|Gammaproteobacteria 1236|Gammaproteobacteria P ABC-type dipeptide oligopeptide nickel transport systems, permease components oppB GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0016020,GO:0022857,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944 - ko:K15581 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00439 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 - - BPD_transp_1 k59_234826_2 565045.NOR51B_2835 7.56e-51 184.0 COG1231@1|root,COG1231@2|Bacteria,1QXX6@1224|Proteobacteria,1T3IZ@1236|Gammaproteobacteria 1236|Gammaproteobacteria E K COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit - - 1.5.99.6 ko:K00316 ko00330,ko00410,ko01100,map00330,map00410,map01100 - R01914,R01915 RC00053,RC00225 ko00000,ko00001,ko01000 - - - NAD_binding_8 k59_1421016_1 570967.JMLV01000007_gene838 7.55e-42 152.0 COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2TQR1@28211|Alphaproteobacteria,2JPQJ@204441|Rhodospirillales 204441|Rhodospirillales C Aldehyde dehydrogenase family - - - - - - - - - - - - Aldedh k59_686794_1 436308.Nmar_1781 9.16e-37 129.0 COG1514@1|root,arCOG01736@2157|Archaea,41SP7@651137|Thaumarchaeota 651137|Thaumarchaeota J Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester - - 3.1.4.58 ko:K01975 - - - - ko00000,ko01000,ko03016 - - - LigT_PEase k59_686794_2 1229909.NSED_09535 1.22e-90 269.0 COG0237@1|root,arCOG01045@2157|Archaea,41SI8@651137|Thaumarchaeota 651137|Thaumarchaeota H AAA domain - - - - - - - - - - - - AAA_17 k59_686794_3 436308.Nmar_1779 2.59e-43 145.0 COG1931@1|root,arCOG01043@2157|Archaea,41SRJ@651137|Thaumarchaeota 651137|Thaumarchaeota S Belongs to the UPF0201 family - - - ko:K09736 - - - - ko00000 - - - RNA_binding k59_686794_4 436308.Nmar_1777 1.39e-122 353.0 COG0846@1|root,arCOG04248@2157|Archaea,41SWP@651137|Thaumarchaeota 651137|Thaumarchaeota K NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form. Deacetylates the N-terminal lysine residue of Alba, the major archaeal chromatin protein and that, in turn, increases Alba's DNA binding affinity, thereby repressing transcription cobB - - ko:K12410 - - - - ko00000,ko01000 - - - SIR2 k59_1308570_1 1229204.AMYY01000006_gene1092 0.000496 47.8 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,2TQR7@28211|Alphaproteobacteria 28211|Alphaproteobacteria T methyl-accepting chemotaxis protein mcpX - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - HAMP,MCPsignal,dCache_1 k59_573772_1 1122137.AQXF01000001_gene2942 0.0 1211.0 COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,2TS8E@28211|Alphaproteobacteria 28211|Alphaproteobacteria I enoyl-CoA hydratase fadJ - 1.1.1.35,4.2.1.17,5.1.2.3 ko:K01782 ko00071,ko00280,ko00281,ko00310,ko00362,ko00380,ko00410,ko00640,ko00650,ko00903,ko00930,ko01040,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00362,map00380,map00410,map00640,map00650,map00903,map00930,map01040,map01100,map01110,map01120,map01130,map01200,map01212 M00032,M00087 R01975,R03026,R03045,R03276,R04137,R04170,R04203,R04204,R04224,R04737,R04738,R04739,R04740,R04741,R04744,R04745,R04746,R04748,R04749,R05066,R05305,R06411,R06412,R06941,R06942,R07935,R07951,R08093,R08094 RC00029,RC00099,RC00117,RC00241,RC00525,RC00831,RC00834,RC00896,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 - - - 3HCDH,3HCDH_N,ECH_1 k59_573772_2 744980.TRICHSKD4_3917 9.39e-137 400.0 COG2873@1|root,COG2873@2|Bacteria,1NQME@1224|Proteobacteria,2TQW9@28211|Alphaproteobacteria 28211|Alphaproteobacteria E O-acetylhomoserine metY GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0003961,GO:0004124,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006555,GO:0006563,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009070,GO:0009086,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0017144,GO:0019344,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0050667,GO:0071265,GO:0071266,GO:0071268,GO:0071269,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.5.1.47,2.5.1.49 ko:K01738,ko:K01740 ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230 M00021 R00897,R01287,R03601,R04859 RC00020,RC02814,RC02821,RC02848 ko00000,ko00001,ko00002,ko01000 - - - Cys_Met_Meta_PP k59_1534599_1 1121939.L861_13910 5.48e-175 501.0 COG3328@1|root,COG3328@2|Bacteria,1MU4P@1224|Proteobacteria,1RNB3@1236|Gammaproteobacteria,1XNN8@135619|Oceanospirillales 135619|Oceanospirillales L Transposase - - - - - - - - - - - - Transposase_mut k59_1138755_1 316407.85675474 2.24e-196 546.0 COG0564@1|root,COG0564@2|Bacteria,1MUBN@1224|Proteobacteria,1RN7F@1236|Gammaproteobacteria,3XNUW@561|Escherichia 1236|Gammaproteobacteria J Responsible for synthesis of pseudouridine from uracil rluD GO:0000027,GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022607,GO:0022613,GO:0022618,GO:0031118,GO:0034470,GO:0034622,GO:0034641,GO:0034660,GO:0042254,GO:0042255,GO:0042273,GO:0043170,GO:0043412,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:1901360 5.4.99.23 ko:K06180 - - - - ko00000,ko01000,ko03009 - - iE2348C_1286.E2348C_2868,iECED1_1282.ECED1_3035,iECSF_1327.ECSF_2432 PseudoU_synth_2,S4 k59_1138761_1 740709.A10D4_08929 4.04e-75 251.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,2QFE3@267893|Idiomarinaceae 1236|Gammaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K18138 ko01501,ko01503,map01501,map01503 M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000 2.A.6.2 - - ACR_tran k59_1195319_1 1523503.JPMY01000037_gene1748 2.16e-63 218.0 COG0643@1|root,COG0784@1|root,COG2198@1|root,COG0643@2|Bacteria,COG0784@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,1RMS6@1236|Gammaproteobacteria 1236|Gammaproteobacteria T COG0643 Chemotaxis protein histidine kinase and related kinases chpA - - ko:K02487,ko:K06596 ko02020,ko02025,map02020,map02025 M00507 - - ko00000,ko00001,ko00002,ko01001,ko02022,ko02035 - - - CheW,H-kinase_dim,HATPase_c,Hpt,Response_reg k59_969210_1 1167006.UWK_00690 8.17e-28 117.0 2F1EJ@1|root,33UF9@2|Bacteria,1NV3G@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_573786_2 665942.HMPREF1022_01283 2.75e-09 57.4 COG1366@1|root,COG1366@2|Bacteria 2|Bacteria T antisigma factor binding btrV - - ko:K04749,ko:K06378 - - - - ko00000,ko03021 - - - STAS,STAS_2 k59_234849_2 436308.Nmar_1410 1.03e-40 141.0 COG1718@1|root,arCOG01180@2157|Archaea,41T2X@651137|Thaumarchaeota 651137|Thaumarchaeota T Serine threonine protein kinase involved in cell cycle control - - 2.7.11.1 ko:K07178 ko03008,map03008 - - - ko00000,ko00001,ko01000,ko01001,ko03009 - - - RIO1 k59_1590458_1 1229909.NSED_00055 2.74e-130 381.0 COG3276@1|root,arCOG01563@2157|Archaea,41S80@651137|Thaumarchaeota 651137|Thaumarchaeota J Initiation factor - - - ko:K03242 ko03013,map03013 - - - ko00000,ko00001,ko03012 - - - GTP_EFTU,eIF2_C k59_1308594_1 357808.RoseRS_3747 9.03e-90 269.0 COG1266@1|root,COG1266@2|Bacteria 2|Bacteria V CAAX protease self-immunity - - - ko:K07052 - - - - ko00000 - - - Abi k59_1138769_1 436308.Nmar_1055 2.26e-136 397.0 COG1530@1|root,arCOG00321@2157|Archaea,41T2C@651137|Thaumarchaeota 651137|Thaumarchaeota L modulator of DNA gyrase - - - ko:K03568 - - - - ko00000,ko01002 - - - PmbA_TldD k59_1138769_2 436308.Nmar_1056 1.32e-06 48.9 COG1573@1|root,arCOG00905@2157|Archaea,41SJ1@651137|Thaumarchaeota 651137|Thaumarchaeota L uracil-DNA glycosylase - - 3.2.2.27 ko:K21929 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - UDG k59_1252029_1 702113.PP1Y_AT36247 3.31e-25 106.0 COG1538@1|root,COG1538@2|Bacteria,1NZN0@1224|Proteobacteria 1224|Proteobacteria MU Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - - - - - - - - - - OEP k59_238772_1 1499967.BAYZ01000029_gene1214 6.93e-63 209.0 COG0504@1|root,COG0504@2|Bacteria,2NNVG@2323|unclassified Bacteria 2|Bacteria F Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates pyrG GO:0001775,GO:0002376,GO:0003674,GO:0003824,GO:0003883,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006213,GO:0006220,GO:0006221,GO:0006241,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008283,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009208,GO:0009209,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0015949,GO:0016020,GO:0016874,GO:0016879,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0032943,GO:0034404,GO:0034641,GO:0034654,GO:0040007,GO:0042098,GO:0042100,GO:0042110,GO:0042113,GO:0042221,GO:0042455,GO:0042493,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045321,GO:0046036,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0046649,GO:0046651,GO:0050896,GO:0055086,GO:0070661,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 6.3.4.2 ko:K01937 ko00240,ko01100,map00240,map01100 M00052 R00571,R00573 RC00010,RC00074 ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_1276,iECO103_1326.ECO103_3323,iNJ661.Rv1699,iPC815.YPO3377 CTP_synth_N,GATase k59_238772_2 84531.JMTZ01000128_gene394 2.71e-09 56.2 COG2214@1|root,COG2214@2|Bacteria,1RC4A@1224|Proteobacteria,1T2IS@1236|Gammaproteobacteria,1X6XF@135614|Xanthomonadales 135614|Xanthomonadales O DnaJ molecular chaperone homology domain - - - - - - - - - - - - DnaJ k59_13473_1 1122137.AQXF01000005_gene1096 2.87e-148 426.0 COG1194@1|root,COG1194@2|Bacteria,1MUD4@1224|Proteobacteria,2TQVX@28211|Alphaproteobacteria 28211|Alphaproteobacteria L a g-specific adenine glycosylase mutY GO:0003674,GO:0003824,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360 - ko:K03575 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - EndIII_4Fe-2S,HhH-GPD,NUDIX_4 k59_352686_1 907931.AEIZ01000010_gene1458 1.8e-10 66.2 COG0577@1|root,COG1136@1|root,COG0577@2|Bacteria,COG1136@2|Bacteria,1TPBJ@1239|Firmicutes,4HBK7@91061|Bacilli,4AX02@81850|Leuconostocaceae 91061|Bacilli V ABC-type antimicrobial peptide transport system, ATPase component yhcA - - ko:K02003,ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran,FtsX,MacB_PCD k59_1199514_1 1050202.KB913024_gene972 1.65e-26 108.0 COG2141@1|root,COG2141@2|Bacteria,2GIY3@201174|Actinobacteria,408DF@622450|Actinopolysporales 201174|Actinobacteria C Luciferase-like monooxygenase - - - - - - - - - - - - Bac_luciferase k59_1199514_2 401526.TcarDRAFT_2063 1.87e-64 211.0 COG1281@1|root,COG1281@2|Bacteria,1TRCH@1239|Firmicutes,4H24X@909932|Negativicutes 909932|Negativicutes O Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress hslO - - ko:K04083 - - - - ko00000,ko03110 - - - HSP33 k59_1538874_1 876044.IMCC3088_857 5.23e-56 187.0 COG2304@1|root,COG2304@2|Bacteria,1QBPM@1224|Proteobacteria,1RQIU@1236|Gammaproteobacteria,1J4PZ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Secreted protein, containing von Willebrand factor (VWF) type - - - - - - - - - - - - - k59_690909_1 436308.Nmar_0522 1.36e-35 127.0 COG1354@1|root,arCOG02610@2157|Archaea,41SMU@651137|Thaumarchaeota 651137|Thaumarchaeota L chromosome segregation and condensation protein ScpA - - - ko:K05896 - - - - ko00000,ko03036 - - - - k59_182714_1 269799.Gmet_2983 3.04e-38 146.0 COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,42NAV@68525|delta/epsilon subdivisions,2WJ3W@28221|Deltaproteobacteria,43TIJ@69541|Desulfuromonadales 28221|Deltaproteobacteria L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity polA - 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1 k59_1764466_2 1123274.KB899409_gene629 8.6e-10 60.1 COG2201@1|root,COG2201@2|Bacteria,2J7EW@203691|Spirochaetes 203691|Spirochaetes T Response regulator receiver domain cheY-3 - - ko:K03413 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko02022,ko02035 - - - Response_reg k59_408667_1 1415778.JQMM01000001_gene1558 8.12e-74 232.0 COG1104@1|root,COG1104@2|Bacteria,1MU1C@1224|Proteobacteria,1RNCD@1236|Gammaproteobacteria,1J4KY@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins iscS GO:0001522,GO:0003674,GO:0003824,GO:0004123,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006790,GO:0006807,GO:0008033,GO:0008144,GO:0008150,GO:0008152,GO:0008483,GO:0009000,GO:0009058,GO:0009451,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016226,GO:0016740,GO:0016769,GO:0016782,GO:0016783,GO:0016829,GO:0016846,GO:0018130,GO:0018131,GO:0019842,GO:0022607,GO:0030170,GO:0031071,GO:0031119,GO:0031163,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046484,GO:0048037,GO:0050662,GO:0051186,GO:0070279,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0097163,GO:0140104,GO:1901360,GO:1901363 2.8.1.7 ko:K04487 ko00730,ko01100,ko04122,map00730,map01100,map04122 - R07460,R11528,R11529 RC01789,RC02313 ko00000,ko00001,ko01000,ko02048,ko03016,ko03029 - - iPC815.YPO2896,iYL1228.KPN_02862 Aminotran_5 k59_408667_2 1453501.JELR01000001_gene3025 1.53e-09 55.5 COG0822@1|root,COG0822@2|Bacteria,1RD5K@1224|Proteobacteria,1S3P1@1236|Gammaproteobacteria,466TH@72275|Alteromonadaceae 1236|Gammaproteobacteria C A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters iscU GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006790,GO:0006807,GO:0006873,GO:0006875,GO:0006879,GO:0008150,GO:0008152,GO:0008198,GO:0009987,GO:0010467,GO:0016043,GO:0016226,GO:0016740,GO:0016782,GO:0019538,GO:0019725,GO:0022607,GO:0030003,GO:0031163,GO:0036455,GO:0042592,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0046916,GO:0048037,GO:0048878,GO:0050801,GO:0051186,GO:0051536,GO:0051537,GO:0051539,GO:0051540,GO:0051604,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0065007,GO:0065008,GO:0071704,GO:0071840,GO:0097428,GO:0098771,GO:1901564 - ko:K04488 - - - - ko00000 - - iAPECO1_1312.APECO1_3996,iB21_1397.B21_02385,iBWG_1329.BWG_2293,iE2348C_1286.E2348C_2812,iEC042_1314.EC042_2733,iEC55989_1330.EC55989_2814,iECABU_c1320.ECABU_c28350,iECBD_1354.ECBD_1155,iECB_1328.ECB_02421,iECDH10B_1368.ECDH10B_2696,iECDH1ME8569_1439.ECDH1ME8569_2456,iECD_1391.ECD_02421,iECED1_1282.ECED1_2960,iECH74115_1262.ECH74115_3761,iECIAI1_1343.ECIAI1_2581,iECIAI39_1322.ECIAI39_2730,iECNA114_1301.ECNA114_2608,iECO103_1326.ECO103_3046,iECO111_1330.ECO111_3253,iECO26_1355.ECO26_3576,iECOK1_1307.ECOK1_2878,iECP_1309.ECP_2534,iECS88_1305.ECS88_2705,iECSE_1348.ECSE_2815,iECSF_1327.ECSF_2373,iECSP_1301.ECSP_3473,iECUMN_1333.ECUMN_2849,iECW_1372.ECW_m2755,iECs_1301.ECs3395,iEKO11_1354.EKO11_1204,iETEC_1333.ETEC_2686,iEcDH1_1363.EcDH1_1139,iEcE24377_1341.EcE24377A_2814,iEcHS_1320.EcHS_A2680,iEcSMS35_1347.EcSMS35_2682,iEcolC_1368.EcolC_1148,iG2583_1286.G2583_3059,iJO1366.b2529,iSDY_1059.SDY_2725,iSFV_1184.SFV_2577,iSF_1195.SF2576,iSFxv_1172.SFxv_2832,iSSON_1240.SSON_2611,iS_1188.S2748,iUMN146_1321.UM146_04055,iUMNK88_1353.UMNK88_3182,iUTI89_1310.UTI89_C2851,iWFL_1372.ECW_m2755,iY75_1357.Y75_RS13200,iZ_1308.Z3796,ic_1306.c3055 NifU_N k59_1199531_1 1123073.KB899242_gene921 2.58e-54 190.0 COG0272@1|root,COG0272@2|Bacteria,1MV3R@1224|Proteobacteria,1RPAV@1236|Gammaproteobacteria,1X2ZU@135614|Xanthomonadales 135614|Xanthomonadales L DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA ligA GO:0003674,GO:0003824,GO:0003909,GO:0003911,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016874,GO:0016886,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360 6.5.1.2 ko:K01972 ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430 - R00382 RC00005 ko00000,ko00001,ko01000,ko03032,ko03400 - - - BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5 k59_917023_1 1125971.ASJB01000062_gene4444 2.55e-08 64.3 COG3209@1|root,COG3209@2|Bacteria 2|Bacteria M self proteolysis - - - - - - - - - - - - RHS_repeat,Tox-HNH-EHHH k59_352709_1 1415779.JOMH01000001_gene881 2.97e-72 231.0 COG0657@1|root,COG0657@2|Bacteria,1NEXK@1224|Proteobacteria,1RNNH@1236|Gammaproteobacteria,1XCFM@135614|Xanthomonadales 135614|Xanthomonadales I Carboxylesterase family - - - - - - - - - - - - Abhydrolase_3 k59_520979_1 748658.KB907313_gene2227 3.26e-91 279.0 COG1894@1|root,COG1894@2|Bacteria,1MV8F@1224|Proteobacteria,1RMUD@1236|Gammaproteobacteria,1WWH3@135613|Chromatiales 135613|Chromatiales C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain nuoF - 1.6.5.3 ko:K00335 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_51K,NADH_4Fe-4S,SLBB k59_917028_1 1444711.CCJF01000005_gene552 6.86e-19 85.9 COG0842@1|root,COG0842@2|Bacteria,2JFF8@204428|Chlamydiae 204428|Chlamydiae V ABC-2 family transporter protein ybhR - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_3 k59_917028_2 686340.Metal_0918 2.02e-11 66.6 COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,1RN5K@1236|Gammaproteobacteria,1XEMB@135618|Methylococcales 135618|Methylococcales MU PFAM Outer membrane efflux protein - - - - - - - - - - - - OEP k59_578013_1 316407.85676926 1.2e-89 270.0 COG0330@1|root,COG0330@2|Bacteria,1MV7R@1224|Proteobacteria,1RM8Z@1236|Gammaproteobacteria,3XM38@561|Escherichia 1236|Gammaproteobacteria O HflC and HflK help govern the stability of phage lambda cII protein, and thereby control the lysogenization frequency of phage lambda. HflKC inhibits the SecY-degrading activity of FtsH, possibly helping quality control of integral membrane proteins hflC GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006508,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008233,GO:0009266,GO:0009408,GO:0009628,GO:0009897,GO:0009986,GO:0016020,GO:0016021,GO:0016787,GO:0019538,GO:0031224,GO:0031226,GO:0031233,GO:0032991,GO:0043086,GO:0043170,GO:0044092,GO:0044238,GO:0044425,GO:0044459,GO:0044464,GO:0050790,GO:0050896,GO:0065007,GO:0065009,GO:0071575,GO:0071704,GO:0071944,GO:0098552,GO:0098796,GO:0140096,GO:1901564 - ko:K04087 - M00742 - - ko00000,ko00002,ko01000 - - - Band_7 k59_578013_2 316407.85676925 1.2e-62 204.0 COG0330@1|root,COG0330@2|Bacteria,1MUM2@1224|Proteobacteria,1RMUG@1236|Gammaproteobacteria,3XNW0@561|Escherichia 1236|Gammaproteobacteria O HflC and HflK could encode or regulate a protease hflK GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006508,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008233,GO:0009266,GO:0009408,GO:0009628,GO:0009897,GO:0009986,GO:0016020,GO:0016021,GO:0016787,GO:0019538,GO:0031224,GO:0031226,GO:0031233,GO:0032991,GO:0043086,GO:0043170,GO:0044092,GO:0044238,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0050790,GO:0050896,GO:0065007,GO:0065009,GO:0071575,GO:0071704,GO:0071944,GO:0098552,GO:0098796,GO:0140096,GO:1901564 - ko:K04088 - M00742 - - ko00000,ko00002,ko01000 - - - Band_7,HflK_N k59_1764485_1 1517681.HW45_25615 3.78e-25 108.0 COG3659@1|root,COG3659@2|Bacteria,1R8TI@1224|Proteobacteria,1S21B@1236|Gammaproteobacteria,1XVR4@135623|Vibrionales 135623|Vibrionales M Carbohydrate-selective porin, OprB family - - - ko:K07267 - - - - ko00000,ko02000 1.B.19.1 - - OprB k59_690926_1 1535422.ND16A_0236 3.16e-05 51.2 COG2982@1|root,COG2982@2|Bacteria,1MUME@1224|Proteobacteria,1RNPC@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Domain of Unknown Function (DUF748) - - - - - - - - - - - - DUF748,OmpA k59_1594959_1 1194165.CAJF01000014_gene1163 6.06e-42 154.0 COG1167@1|root,COG1167@2|Bacteria,2GM6I@201174|Actinobacteria,4FMT5@85023|Microbacteriaceae 201174|Actinobacteria EK helix_turn_helix gluconate operon transcriptional repressor ptsJ - - - - - - - - - - - Aminotran_1_2,GntR k59_1764497_1 29540.C481_12094 1.2e-10 62.0 COG0118@1|root,arCOG00089@2157|Archaea,2XTJ7@28890|Euryarchaeota,23S4N@183963|Halobacteria 28890|Euryarchaeota E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR hisH - - ko:K02501 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04558 RC00010,RC01190,RC01943 ko00000,ko00001,ko00002,ko01000 - - - GATase k59_1764497_2 1122962.AULH01000002_gene3505 5.06e-21 91.3 COG0106@1|root,COG0106@2|Bacteria,1MW6S@1224|Proteobacteria,2TRSG@28211|Alphaproteobacteria,36XHE@31993|Methylocystaceae 28211|Alphaproteobacteria E Histidine biosynthesis protein hisA GO:0000105,GO:0000162,GO:0003674,GO:0003824,GO:0003949,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.3.1.16 ko:K01814 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04640 RC00945 ko00000,ko00001,ko00002,ko01000 - - - His_biosynth k59_1030893_1 1288494.EBAPG3_25390 2.21e-81 256.0 COG0285@1|root,COG0285@2|Bacteria,1MVCH@1224|Proteobacteria,2VI0H@28216|Betaproteobacteria,371U0@32003|Nitrosomonadales 28216|Betaproteobacteria H Belongs to the folylpolyglutamate synthase family folC - 6.3.2.12,6.3.2.17 ko:K11754 ko00790,ko01100,map00790,map01100 M00126,M00841 R00942,R02237,R04241 RC00064,RC00090,RC00162 ko00000,ko00001,ko00002,ko01000 - - - Mur_ligase_C,Mur_ligase_M k59_861595_1 1005395.CSV86_00883 2.18e-84 263.0 COG0484@1|root,COG0484@2|Bacteria,1MUZ4@1224|Proteobacteria,1RP09@1236|Gammaproteobacteria 1236|Gammaproteobacteria O displays overlapping activities with DnaJ, but functions under different conditions, probably acting as a molecular chaperone in an adaptive response to environmental stresses other than heat shock. Lacks autonomous chaperone activity cbpA GO:0003674,GO:0003676,GO:0003677,GO:0003681,GO:0005488,GO:0097159,GO:1901363 - ko:K05516 - - - - ko00000,ko03036,ko03110 - - - DnaJ,DnaJ_C k59_972699_1 436308.Nmar_0503 4.42e-20 92.4 arCOG12815@1|root,arCOG12815@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_13540_1 706434.HMPREF9429_00216 2.39e-17 84.0 COG1132@1|root,COG1132@2|Bacteria,1TP0B@1239|Firmicutes,4H20M@909932|Negativicutes 909932|Negativicutes V lipid A export permease ATP-binding protein MsbA msbA - - ko:K11085 ko02010,map02010 - - - ko00000,ko00001,ko01000,ko02000 3.A.1.106 - - ABC_membrane,ABC_tran k59_1538920_1 751994.AGIG01000008_gene1068 2.44e-09 56.6 COG0066@1|root,COG0066@2|Bacteria,1MVXB@1224|Proteobacteria,1RNMK@1236|Gammaproteobacteria,1J573@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate leuD - 4.2.1.33,4.2.1.35 ko:K01704 ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230 M00432,M00535 R03896,R03898,R03968,R04001,R10170 RC00976,RC00977,RC01041,RC01046,RC03072 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase_C k59_1538920_2 1144310.PMI07_004592 4.14e-86 268.0 COG0065@1|root,COG0065@2|Bacteria,1MVYR@1224|Proteobacteria,2TR6K@28211|Alphaproteobacteria,4B8XI@82115|Rhizobiaceae 28211|Alphaproteobacteria E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate leuC - 4.2.1.33,4.2.1.35 ko:K01703 ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230 M00432,M00535 R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170 RC00497,RC00976,RC00977,RC01041,RC01046,RC03072 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase k59_296277_1 247633.GP2143_17661 2e-121 363.0 COG2303@1|root,COG2303@2|Bacteria,1MU3F@1224|Proteobacteria,1RPBQ@1236|Gammaproteobacteria,1J5ZV@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E COG2303 Choline dehydrogenase and related flavoproteins neoG - - - - - - - - - - - FAD_binding_2,GMC_oxred_C,GMC_oxred_N,NAD_binding_8 k59_296277_2 247633.GP2143_17656 2.42e-57 187.0 2CDAN@1|root,3134Z@2|Bacteria,1N8A0@1224|Proteobacteria,1T67A@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Gluconate 2-dehydrogenase subunit 3 - - - - - - - - - - - - Gluconate_2-dh3 k59_521024_1 1122137.AQXF01000003_gene2265 2.04e-95 302.0 COG1913@1|root,COG1913@2|Bacteria,1MY52@1224|Proteobacteria,2TUDY@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Domain of unknown function (DUF5117) - - - - - - - - - - - - DUF4953,DUF5117 k59_408693_1 118166.JH976537_gene4773 1.61e-35 127.0 COG0394@1|root,COG0394@2|Bacteria,1G5U8@1117|Cyanobacteria,1HB72@1150|Oscillatoriales 1117|Cyanobacteria T Low molecular weight phosphotyrosine protein phosphatase ptpA - 3.1.3.48 ko:K01104 - - - - ko00000,ko01000 - - - LMWPc k59_408693_2 76114.ebA2733 1.19e-39 139.0 COG0071@1|root,COG0071@2|Bacteria,1RH6E@1224|Proteobacteria,2VRIE@28216|Betaproteobacteria 28216|Betaproteobacteria O Belongs to the small heat shock protein (HSP20) family - - - ko:K13993 ko04141,map04141 - - - ko00000,ko00001,ko03110 - - - HSP20 k59_408693_3 69042.WH5701_10295 9.47e-28 108.0 COG3145@1|root,COG3145@2|Bacteria,1G503@1117|Cyanobacteria,1H07Z@1129|Synechococcus 1117|Cyanobacteria L Alkylated DNA repair protein alkB - - - - - - - - - - - 2OG-FeII_Oxy_2 k59_1764520_1 1120934.KB894451_gene2938 6.47e-16 75.9 2DP8R@1|root,32UKH@2|Bacteria,2IFBP@201174|Actinobacteria,4E378@85010|Pseudonocardiales 201174|Actinobacteria - - amfC - - - - - - - - - - - - k59_1764520_2 202952.BBLI01000035_gene2411 4.3e-29 114.0 COG0739@1|root,COG0739@2|Bacteria,1RK0U@1224|Proteobacteria,1SYMP@1236|Gammaproteobacteria,3NKAS@468|Moraxellaceae 1236|Gammaproteobacteria M Peptidase family M23 - - - ko:K21472 - - - - ko00000,ko01000,ko01002,ko01011 - - - Peptidase_M23 k59_1651867_1 498211.CJA_2554 5.33e-82 256.0 COG2256@1|root,COG2256@2|Bacteria,1MUVS@1224|Proteobacteria,1RPBY@1236|Gammaproteobacteria,1FFVU@10|Cellvibrio 1236|Gammaproteobacteria L MgsA AAA+ ATPase C terminal rarA GO:0005575,GO:0005622,GO:0005623,GO:0005657,GO:0005694,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006310,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0030894,GO:0032991,GO:0032993,GO:0034641,GO:0034645,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044422,GO:0044424,GO:0044427,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901576 - ko:K07478 - - - - ko00000 - - - AAA,AAA_assoc_2,MgsA_C,RuvB_N k59_1199581_1 237368.SCABRO_03070 7.5e-15 74.7 COG0845@1|root,COG0845@2|Bacteria 2|Bacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - - - - - - - - - - HlyD_3,HlyD_D23 k59_1199581_2 1304275.C41B8_06427 5.23e-42 154.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1S1GP@1236|Gammaproteobacteria 1236|Gammaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_690952_1 1122217.KB899584_gene77 2.02e-53 181.0 COG0552@1|root,COG0552@2|Bacteria,1TPRI@1239|Firmicutes,4H1WP@909932|Negativicutes 909932|Negativicutes U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) ftsY - - ko:K03110 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2,3.A.5.7 - - SRP54,SRP54_N k59_578090_1 85643.Tmz1t_3689 3.21e-25 97.1 COG0745@1|root,COG0745@2|Bacteria,1RI9T@1224|Proteobacteria,2VSSD@28216|Betaproteobacteria,2KWTI@206389|Rhodocyclales 206389|Rhodocyclales T response regulator receiver pilH - - ko:K02658 ko02020,ko02025,map02020,map02025 M00507 - - ko00000,ko00001,ko00002,ko02022,ko02035,ko02044 - - - Response_reg k59_805620_1 375286.mma_2534 1.47e-38 134.0 COG3576@1|root,COG3576@2|Bacteria,1MWG9@1224|Proteobacteria,2VQ6P@28216|Betaproteobacteria,474AQ@75682|Oxalobacteraceae 28216|Betaproteobacteria S Pfam:Pyridox_oxidase - - - ko:K07006 - - - - ko00000 - - - Putative_PNPOx k59_973704_1 999141.GME_04612 1.66e-86 271.0 COG0504@1|root,COG0504@2|Bacteria,1MUIT@1224|Proteobacteria,1RM92@1236|Gammaproteobacteria,1XI53@135619|Oceanospirillales 135619|Oceanospirillales F Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates pyrG - 6.3.4.2 ko:K01937 ko00240,ko01100,map00240,map01100 M00052 R00571,R00573 RC00010,RC00074 ko00000,ko00001,ko00002,ko01000 - - - CTP_synth_N,GATase k59_973708_1 1100720.ALKN01000028_gene2481 1.54e-29 113.0 COG1028@1|root,COG1028@2|Bacteria,1MXNQ@1224|Proteobacteria,2VJQ2@28216|Betaproteobacteria,4A9SP@80864|Comamonadaceae 28216|Betaproteobacteria IQ PFAM Short-chain dehydrogenase reductase SDR - - - - - - - - - - - - adh_short,adh_short_C2 k59_973708_2 1088721.NSU_3485 3.84e-70 230.0 COG1545@1|root,COG3425@1|root,COG1545@2|Bacteria,COG3425@2|Bacteria,1QV6D@1224|Proteobacteria,2TTB1@28211|Alphaproteobacteria,2K2KH@204457|Sphingomonadales 204457|Sphingomonadales I DUF35 OB-fold domain, acyl-CoA-associated - - - - - - - - - - - - ACP_syn_III_C,OB_aCoA_assoc k59_1256952_1 32264.tetur06g01590.1 3.61e-14 78.2 COG5520@1|root,KOG2566@2759|Eukaryota,39A7W@33154|Opisthokonta,3BEX4@33208|Metazoa,3CS4D@33213|Bilateria,41X21@6656|Arthropoda 33208|Metazoa G Glucosylceramidase activity. It is involved in the biological process described with sphingolipid metabolic process GBA GO:0000323,GO:0001817,GO:0001818,GO:0001932,GO:0001933,GO:0003008,GO:0003674,GO:0003824,GO:0004348,GO:0004553,GO:0005102,GO:0005124,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005615,GO:0005622,GO:0005623,GO:0005737,GO:0005764,GO:0005765,GO:0005773,GO:0005774,GO:0005775,GO:0006066,GO:0006469,GO:0006629,GO:0006643,GO:0006664,GO:0006665,GO:0006670,GO:0006672,GO:0006677,GO:0006678,GO:0006680,GO:0006687,GO:0006807,GO:0006914,GO:0006950,GO:0006986,GO:0006996,GO:0007033,GO:0007154,GO:0007275,GO:0007568,GO:0007610,GO:0007611,GO:0007613,GO:0007626,GO:0008150,GO:0008152,GO:0008340,GO:0008344,GO:0008610,GO:0009056,GO:0009058,GO:0009267,GO:0009268,GO:0009410,GO:0009605,GO:0009628,GO:0009653,GO:0009719,GO:0009725,GO:0009887,GO:0009889,GO:0009891,GO:0009892,GO:0009893,GO:0009894,GO:0009896,GO:0009966,GO:0009968,GO:0009987,GO:0009991,GO:0010033,GO:0010259,GO:0010506,GO:0010508,GO:0010556,GO:0010557,GO:0010562,GO:0010563,GO:0010604,GO:0010605,GO:0010638,GO:0010646,GO:0010647,GO:0010648,GO:0010821,GO:0010822,GO:0010941,GO:0014070,GO:0016020,GO:0016042,GO:0016043,GO:0016137,GO:0016139,GO:0016236,GO:0016241,GO:0016787,GO:0016798,GO:0019220,GO:0019222,GO:0019377,GO:0019725,GO:0019751,GO:0019898,GO:0023021,GO:0023051,GO:0023056,GO:0023057,GO:0030104,GO:0030148,GO:0030149,GO:0030162,GO:0030534,GO:0031090,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031328,GO:0031329,GO:0031331,GO:0031333,GO:0031347,GO:0031348,GO:0031399,GO:0031400,GO:0031401,GO:0031644,GO:0031646,GO:0031667,GO:0031668,GO:0031669,GO:0031960,GO:0031974,GO:0032101,GO:0032102,GO:0032268,GO:0032269,GO:0032270,GO:0032434,GO:0032436,GO:0032459,GO:0032460,GO:0032462,GO:0032463,GO:0032501,GO:0032502,GO:0032675,GO:0032715,GO:0033043,GO:0033554,GO:0033561,GO:0033574,GO:0033673,GO:0033993,GO:0034097,GO:0034311,GO:0034312,GO:0034612,GO:0034620,GO:0034641,GO:0035303,GO:0035304,GO:0035306,GO:0035307,GO:0035966,GO:0035967,GO:0042176,GO:0042221,GO:0042325,GO:0042326,GO:0042391,GO:0042493,GO:0042592,GO:0042594,GO:0043086,GO:0043202,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043243,GO:0043244,GO:0043254,GO:0043405,GO:0043407,GO:0043408,GO:0043409,GO:0043549,GO:0043588,GO:0043589,GO:0043603,GO:0043604,GO:0043627,GO:0044057,GO:0044087,GO:0044092,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044249,GO:0044255,GO:0044271,GO:0044281,GO:0044283,GO:0044421,GO:0044422,GO:0044424,GO:0044425,GO:0044437,GO:0044444,GO:0044446,GO:0044464,GO:0045732,GO:0045760,GO:0045859,GO:0045862,GO:0045936,GO:0045937,GO:0046165,GO:0046173,GO:0046466,GO:0046467,GO:0046477,GO:0046479,GO:0046512,GO:0046513,GO:0046514,GO:0046519,GO:0046520,GO:0048513,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048545,GO:0048583,GO:0048585,GO:0048731,GO:0048856,GO:0048871,GO:0048878,GO:0050727,GO:0050728,GO:0050746,GO:0050747,GO:0050789,GO:0050790,GO:0050794,GO:0050877,GO:0050878,GO:0050890,GO:0050891,GO:0050896,GO:0051128,GO:0051129,GO:0051130,GO:0051171,GO:0051172,GO:0051173,GO:0051174,GO:0051239,GO:0051240,GO:0051241,GO:0051246,GO:0051247,GO:0051248,GO:0051338,GO:0051348,GO:0051384,GO:0051716,GO:0051969,GO:0051971,GO:0060249,GO:0060255,GO:0060548,GO:0061136,GO:0061919,GO:0065007,GO:0065008,GO:0065009,GO:0070013,GO:0070050,GO:0070887,GO:0071310,GO:0071345,GO:0071356,GO:0071496,GO:0071548,GO:0071704,GO:0071840,GO:0071900,GO:0071901,GO:0080090,GO:0080134,GO:0097066,GO:0097164,GO:0097327,GO:0098588,GO:0098780,GO:0098805,GO:0098852,GO:0098900,GO:0098908,GO:1901135,GO:1901136,GO:1901214,GO:1901215,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901615,GO:1901617,GO:1901654,GO:1901657,GO:1901658,GO:1901700,GO:1901800,GO:1901804,GO:1901805,GO:1902531,GO:1902532,GO:1903050,GO:1903052,GO:1903059,GO:1903061,GO:1903146,GO:1903362,GO:1903364,GO:1903509,GO:1903599,GO:1904350,GO:1904457,GO:1904923,GO:1904925,GO:1905037,GO:1905165,GO:2000058,GO:2000060,GO:2000112 3.2.1.45 ko:K01201 ko00511,ko00600,ko01100,ko04142,map00511,map00600,map01100,map04142 - R01498 RC00059,RC00451 ko00000,ko00001,ko01000 - GH30 - Glyco_hydro_30,Glyco_hydro_30C k59_183981_1 926569.ANT_13310 6.75e-41 150.0 2DMUC@1|root,32TQR@2|Bacteria,2G6MF@200795|Chloroflexi 200795|Chloroflexi S CpXC protein - - - - - - - - - - - - CpXC k59_1426284_1 511145.b3572 3e-125 365.0 COG3977@1|root,COG3977@2|Bacteria,1MVRW@1224|Proteobacteria,1RNK1@1236|Gammaproteobacteria,3XNPA@561|Escherichia 1236|Gammaproteobacteria E Valine--pyruvate aminotransferase avtA GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006522,GO:0006523,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009042,GO:0009058,GO:0009078,GO:0009079,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0019752,GO:0030632,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046144,GO:0046145,GO:0046394,GO:0046416,GO:0046436,GO:0046437,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.6.1.66 ko:K00835 ko00290,ko01100,ko01110,ko01130,map00290,map01100,map01110,map01130 - R01215 RC00008,RC00036 ko00000,ko00001,ko01000,ko01007 - - iEKO11_1354.EKO11_0154,iEcSMS35_1347.EcSMS35_3895 Aminotran_1_2 k59_1314164_1 983544.Lacal_1445 1.01e-118 361.0 COG0457@1|root,COG0642@1|root,COG0784@1|root,COG0457@2|Bacteria,COG0784@2|Bacteria,COG2205@2|Bacteria,4NDXU@976|Bacteroidetes,1HYZK@117743|Flavobacteriia 976|Bacteroidetes T Histidine kinase - - - ko:K20971 ko02025,map02025 - - - ko00000,ko00001,ko01001,ko02022 - - - HATPase_c,HisKA,Response_reg,TPR_12,TPR_8 k59_353796_1 88036.EFJ10840 2.07e-15 78.6 COG0667@1|root,KOG1575@2759|Eukaryota,37HWG@33090|Viridiplantae,3GH58@35493|Streptophyta 35493|Streptophyta C aldo-keto reductase - - - - - - - - - - - - Aldo_ket_red k59_1143852_1 1151127.KB906325_gene5075 8.03e-14 72.0 COG3970@1|root,COG3970@2|Bacteria,1MVA2@1224|Proteobacteria,1S18A@1236|Gammaproteobacteria,1YRDE@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria S Fumarylacetoacetate (FAA) hydrolase family - - 4.2.1.141 ko:K14259 ko00040,map00040 - R09186 RC00429 ko00000,ko00001,ko01000 - - - FAA_hydrolase k59_353797_1 795666.MW7_0915 7.99e-119 374.0 COG0587@1|root,COG0587@2|Bacteria,1MUIF@1224|Proteobacteria,2VH3F@28216|Betaproteobacteria,1K1A9@119060|Burkholderiaceae 28216|Betaproteobacteria L DNA polymerase dnaE - 2.7.7.7 ko:K02337 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon k59_1200710_1 1229909.NSED_01340 5.9e-121 348.0 COG5424@1|root,arCOG06031@2157|Archaea,41SJK@651137|Thaumarchaeota 651137|Thaumarchaeota H Iron-containing redox enzyme - - 1.3.3.11 ko:K06137 - - - - ko00000,ko01000 - - - - k59_692092_1 314225.ELI_14900 2.02e-129 372.0 COG2801@1|root,COG2801@2|Bacteria,1MVN5@1224|Proteobacteria,2TQK0@28211|Alphaproteobacteria,2K2F6@204457|Sphingomonadales 204457|Sphingomonadales L COG2801 Transposase and inactivated derivatives - - - - - - - - - - - - HTH_21,rve,rve_3 k59_14632_2 670307.HYPDE_23383 1.64e-11 64.3 COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,2TRWM@28211|Alphaproteobacteria 28211|Alphaproteobacteria P Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K15726 - - - - ko00000,ko02000 2.A.6.1.2 - - ACR_tran k59_635617_1 187272.Mlg_1601 1.25e-46 171.0 COG0204@1|root,COG1022@1|root,COG0204@2|Bacteria,COG1022@2|Bacteria,1MU4D@1224|Proteobacteria,1RPNE@1236|Gammaproteobacteria,1X042@135613|Chromatiales 135613|Chromatiales Q Phosphate acyltransferases - - 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding,AMP-binding_C,Acyltransferase,PP-binding k59_805651_1 1088721.NSU_1288 1.27e-74 245.0 COG1529@1|root,COG1529@2|Bacteria,1QTTJ@1224|Proteobacteria,2TQVK@28211|Alphaproteobacteria,2K25R@204457|Sphingomonadales 204457|Sphingomonadales C aerobic-type carbon monoxide dehydrogenase, large subunit CoxL - - 1.3.99.16 ko:K07303 - - - - ko00000,ko01000 - - - Ald_Xan_dh_C,Ald_Xan_dh_C2 k59_862683_1 436308.Nmar_0831 4.91e-44 152.0 COG0057@1|root,arCOG00493@2157|Archaea,41SDF@651137|Thaumarchaeota 651137|Thaumarchaeota G Belongs to the glyceraldehyde-3-phosphate dehydrogenase family - - 1.2.1.59 ko:K00150 ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003,M00165,M00166 R01061,R01063 RC00149 ko00000,ko00001,ko00002,ko01000 - - - - k59_1200741_1 702113.PP1Y_AT33731 1.3e-107 325.0 COG0728@1|root,COG0728@2|Bacteria,1MUH0@1224|Proteobacteria,2TS44@28211|Alphaproteobacteria,2K03M@204457|Sphingomonadales 204457|Sphingomonadales S Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane murJ - - ko:K03980 - - - - ko00000,ko01011,ko02000 2.A.66.4 - - MVIN k59_1087483_1 1279017.AQYJ01000020_gene1255 5.01e-68 220.0 COG0617@1|root,COG0617@2|Bacteria,1MU2X@1224|Proteobacteria,1RPFJ@1236|Gammaproteobacteria,4641Q@72275|Alteromonadaceae 1236|Gammaproteobacteria J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate cca GO:0003674,GO:0003824,GO:0004652,GO:0004810,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0070566,GO:0071704,GO:0090304,GO:1901360,GO:1990817 2.7.7.72 ko:K00974 ko03013,map03013 - R09382,R09383,R09384,R09386 RC00078 ko00000,ko00001,ko01000,ko03016 - - - HD,PolyA_pol,PolyA_pol_RNAbd k59_635628_1 1122137.AQXF01000005_gene1318 5.29e-12 64.7 COG3590@1|root,COG3590@2|Bacteria,1MVNQ@1224|Proteobacteria,2TRU4@28211|Alphaproteobacteria 28211|Alphaproteobacteria O peptidase, M13 - - 3.4.24.71 ko:K01415,ko:K07386 - - - - ko00000,ko01000,ko01002,ko04147 - - - Peptidase_M13,Peptidase_M13_N k59_635628_2 1158614.I592_02027 2e-10 61.2 COG3797@1|root,COG3797@2|Bacteria 2|Bacteria S Protein of unknown function (DUF1697) - - - - - - - - - - - - DUF1697 k59_1256994_1 756272.Plabr_1364 1.53e-111 335.0 COG3119@1|root,COG3119@2|Bacteria,2J24P@203682|Planctomycetes 203682|Planctomycetes P Sulfatase - - 3.1.6.1 ko:K01130 ko00140,ko00600,map00140,map00600 - R03980,R04856 RC00128,RC00231 ko00000,ko00001,ko01000 - - - Sulfatase k59_748359_1 1096930.L284_07285 2.39e-133 387.0 COG0133@1|root,COG0133@2|Bacteria,1MUS8@1224|Proteobacteria,2TSHK@28211|Alphaproteobacteria,2K1IA@204457|Sphingomonadales 204457|Sphingomonadales E The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine trpB - 4.2.1.20 ko:K01696 ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230 M00023 R00674,R02340,R02722 RC00209,RC00210,RC00700,RC00701,RC02868 ko00000,ko00001,ko00002,ko01000 - - - PALP k59_1314181_1 1122137.AQXF01000009_gene11 8.2e-149 456.0 COG0085@1|root,COG0085@2|Bacteria,1MUC4@1224|Proteobacteria,2TS7S@28211|Alphaproteobacteria 28211|Alphaproteobacteria K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoB GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234 2.7.7.6 ko:K03043 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7 k59_1652954_1 1453501.JELR01000001_gene2453 1.06e-101 304.0 COG0372@1|root,COG0372@2|Bacteria,1MUKX@1224|Proteobacteria,1RNT1@1236|Gammaproteobacteria,465RE@72275|Alteromonadaceae 1236|Gammaproteobacteria C Belongs to the citrate synthase family prpC GO:0003674,GO:0003824,GO:0004108,GO:0006082,GO:0006091,GO:0006113,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0009987,GO:0015980,GO:0016740,GO:0016746,GO:0016829,GO:0016830,GO:0016833,GO:0016999,GO:0017144,GO:0019541,GO:0019679,GO:0019752,GO:0032787,GO:0036440,GO:0043436,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0046459,GO:0046912,GO:0050440,GO:0055114,GO:0071704 2.3.3.5 ko:K01659 ko00640,map00640 - R00931 RC00004,RC00406,RC02827 ko00000,ko00001,ko01000 - - iECED1_1282.ECED1_0365,iECIAI1_1343.ECIAI1_0334,iECIAI39_1322.ECIAI39_0347,iECP_1309.ECP_0408,iECSF_1327.ECSF_0308,iEcE24377_1341.EcE24377A_0357,iJN746.PP_2335,iLF82_1304.LF82_1740,iNRG857_1313.NRG857_01630 Citrate_synt k59_579136_1 316407.1651560 1.01e-76 239.0 COG0538@1|root,COG0538@2|Bacteria,1MW3J@1224|Proteobacteria,1RNMD@1236|Gammaproteobacteria,3XMJ1@561|Escherichia 1236|Gammaproteobacteria C Isocitrate dehydrogenase icd GO:0003674,GO:0003824,GO:0004448,GO:0004450,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006091,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0022900,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0055114 1.1.1.42 ko:K00031 ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146 M00009,M00010,M00173,M00740 R00267,R00268,R01899 RC00001,RC00084,RC00114,RC00626,RC02801 br01601,ko00000,ko00001,ko00002,ko01000 - - e_coli_core.b1136,iAF1260.b1136,iECDH1ME8569_1439.ECDH1ME8569_1071,iEcDH1_1363.EcDH1_2511,iJN746.PP_4011,iJO1366.b1136,iJR904.b1136,iY75_1357.Y75_RS05930,iYL1228.KPN_01144 Iso_dh k59_466033_1 1122918.KB907252_gene2848 3.52e-19 87.4 COG4675@1|root,COG4675@2|Bacteria,1V943@1239|Firmicutes,4HJCC@91061|Bacilli,26YNV@186822|Paenibacillaceae 91061|Bacilli S Phage Tail Collar Domain - - - - - - - - - - - - Collar k59_871255_1 325452.fgenesh_scip_prom.46568.6101 3.21e-16 85.1 COG0642@1|root,KOG0519@2759|Eukaryota,3QIR0@4776|Peronosporales 4776|Peronosporales T His Kinase A (phospho-acceptor) domain - - - - - - - - - - - - HATPase_c,HisKA k59_529444_1 305900.GV64_01250 6.87e-109 326.0 COG0715@1|root,COG0715@2|Bacteria,1MWDN@1224|Proteobacteria,1RPUP@1236|Gammaproteobacteria,1XIGG@135619|Oceanospirillales 135619|Oceanospirillales P COG0715 ABC-type nitrate sulfonate bicarbonate transport systems, periplasmic components nrtC - - ko:K15576 ko00910,ko02010,map00910,map02010 M00438 - - ko00000,ko00001,ko00002,ko02000 3.A.1.16.1,3.A.1.16.2 - - NMT1_2 k59_23140_1 379066.GAU_2049 3.6e-67 213.0 COG0730@1|root,COG0730@2|Bacteria,1ZUET@142182|Gemmatimonadetes 142182|Gemmatimonadetes S response to heat - - - - - - - - - - - - - k59_1434063_1 589865.DaAHT2_1105 1.12e-94 290.0 COG0059@1|root,COG0059@2|Bacteria,1MV7M@1224|Proteobacteria,42MRS@68525|delta/epsilon subdivisions,2WJW8@28221|Deltaproteobacteria,2MIRN@213118|Desulfobacterales 28221|Deltaproteobacteria EH Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by ilvC - 1.1.1.86 ko:K00053 ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R03051,R04439,R04440,R05068,R05069,R05071 RC00726,RC00836,RC00837,RC01726 ko00000,ko00001,ko00002,ko01000 - - - IlvC,IlvN k59_700838_1 1042377.AFPJ01000055_gene963 6.38e-22 98.6 28MA5@1|root,2ZANY@2|Bacteria,1RIQ2@1224|Proteobacteria,1S60Q@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_529445_1 1056820.KB900696_gene3989 7.95e-108 317.0 COG0842@1|root,COG0842@2|Bacteria,1MUH1@1224|Proteobacteria,1RP0Z@1236|Gammaproteobacteria,2PMM4@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria V ABC-2 type transporter yadH GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane k59_1321663_1 762376.AXYL_02200 3.37e-67 213.0 COG1028@1|root,COG1028@2|Bacteria,1MXNQ@1224|Proteobacteria,2VJQ2@28216|Betaproteobacteria,3T3E9@506|Alcaligenaceae 28216|Betaproteobacteria IQ Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases - - - - - - - - - - - - adh_short_C2 k59_1492556_1 316407.85676928 7.44e-160 456.0 COG0104@1|root,COG0104@2|Bacteria,1MU5B@1224|Proteobacteria,1RNEW@1236|Gammaproteobacteria,3XNIR@561|Escherichia 1236|Gammaproteobacteria F Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP purA GO:0003674,GO:0003824,GO:0004019,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0015949,GO:0016874,GO:0016879,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033554,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046033,GO:0046040,GO:0046085,GO:0046086,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0050896,GO:0051716,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 6.3.4.4 ko:K01939 ko00230,ko00250,ko01100,map00230,map00250,map01100 M00049 R01135 RC00458,RC00459 ko00000,ko00001,ko00002,ko01000 - - iECNA114_1301.ECNA114_4393,iECSF_1327.ECSF_4063,iJN746.PP_4889 Adenylsucc_synt k59_362782_1 118005.AWNK01000007_gene701 1.28e-16 83.2 COG3713@1|root,COG3713@2|Bacteria 2|Bacteria M MltA-interacting MipA family protein - - - ko:K07274 - - - - ko00000,ko02000 9.B.99.1 - - MipA k59_587633_1 243231.GSU0865 1.72e-17 82.0 COG3599@1|root,COG3599@2|Bacteria,1NCAV@1224|Proteobacteria,42VH6@68525|delta/epsilon subdivisions,2WS27@28221|Deltaproteobacteria 28221|Deltaproteobacteria D PFAM DivIVA family protein - - - ko:K04074 - - - - ko00000,ko03036 - - - DivIVA k59_191969_1 1122137.AQXF01000001_gene2568 4.81e-203 587.0 COG1643@1|root,COG1643@2|Bacteria,1MUEQ@1224|Proteobacteria,2TRMJ@28211|Alphaproteobacteria 28211|Alphaproteobacteria L ATP-dependent helicase hrpB - 3.6.4.13 ko:K03579 - - - - ko00000,ko01000 - - - DEAD,HA2,Helicase_C,HrpB_C k59_813105_1 998674.ATTE01000001_gene627 0.000812 43.1 COG1663@1|root,COG1663@2|Bacteria,1MU8G@1224|Proteobacteria,1RMMW@1236|Gammaproteobacteria,460ED@72273|Thiotrichales 72273|Thiotrichales M Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) lpxK - 2.7.1.130 ko:K00912 ko00540,ko01100,map00540,map01100 M00060 R04657 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000,ko01005 - - - LpxK k59_813105_2 232721.Ajs_2307 3.44e-23 97.1 COG1212@1|root,COG1212@2|Bacteria,1MUUU@1224|Proteobacteria,2VINM@28216|Betaproteobacteria,4A9U8@80864|Comamonadaceae 28216|Betaproteobacteria M Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria kdsB - 2.7.7.38 ko:K00979 ko00540,ko01100,map00540,map01100 M00063 R03351,R11396 RC00152,RC00910 ko00000,ko00001,ko00002,ko01000,ko01005 - - - CTP_transf_3 k59_191971_1 1297865.APJD01000012_gene1374 6.19e-11 62.4 COG0372@1|root,COG0372@2|Bacteria,1MXFW@1224|Proteobacteria,2TTMR@28211|Alphaproteobacteria,3JREW@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria C Citrate synthase, C-terminal domain MA20_39855 - 2.3.3.1 ko:K01647 ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00740 R00351 RC00004,RC00067 br01601,ko00000,ko00001,ko00002,ko01000 - - - Citrate_synt,HTH_17,MerR_1 k59_1209291_1 1123487.KB892865_gene1375 9.11e-78 241.0 28MVD@1|root,2ZB2Y@2|Bacteria,1R8NK@1224|Proteobacteria,2VPRP@28216|Betaproteobacteria,2KZJK@206389|Rhodocyclales 206389|Rhodocyclales S Protein of unknown function (DUF4043) - - - - - - - - - - - - DUF4043 k59_1209291_3 626887.J057_01800 3.62e-08 51.2 2DN5T@1|root,32VQG@2|Bacteria,1N6A1@1224|Proteobacteria,1SB7Q@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_643369_1 861299.J421_0704 1.93e-54 191.0 COG0577@1|root,COG0577@2|Bacteria,1ZUI2@142182|Gemmatimonadetes 142182|Gemmatimonadetes V MacB-like periplasmic core domain - - - - - - - - - - - - FtsX,MacB_PCD k59_700884_1 246197.MXAN_5325 1.11e-11 70.1 COG0737@1|root,COG0737@2|Bacteria,1MX03@1224|Proteobacteria,42Q71@68525|delta/epsilon subdivisions,2WK8Q@28221|Deltaproteobacteria 28221|Deltaproteobacteria F Belongs to the 5'-nucleotidase family - - 3.1.3.5 ko:K01081 ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110 - R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346 RC00017 ko00000,ko00001,ko01000 - - - 5_nucleotid_C,Metallophos k59_1264373_1 1187851.A33M_2290 3.45e-43 146.0 COG0512@1|root,COG0512@2|Bacteria,1MV5Y@1224|Proteobacteria,2TU3N@28211|Alphaproteobacteria,3FD26@34008|Rhodovulum 28211|Alphaproteobacteria EH Peptidase C26 trpG - 2.6.1.85,4.1.3.27 ko:K01658,ko:K01664 ko00400,ko00405,ko00790,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map00790,map01100,map01110,map01130,map01230,map02024,map02025 M00023 R00985,R00986,R01716 RC00010,RC01418,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 - - - GATase k59_1264373_2 1430440.MGMSRv2_0877 2.17e-28 117.0 COG2861@1|root,COG2861@2|Bacteria,1N3JP@1224|Proteobacteria,2TUFD@28211|Alphaproteobacteria,2JRXP@204441|Rhodospirillales 204441|Rhodospirillales S protein conserved in bacteria - - - ko:K09798 - - - - ko00000 - - - Polysacc_deac_2 k59_1434099_1 880070.Cycma_0969 5.24e-36 134.0 COG3264@1|root,COG3264@2|Bacteria,4NEAM@976|Bacteroidetes,47PIS@768503|Cytophagia 976|Bacteroidetes M Small-conductance mechanosensitive channel - - - - - - - - - - - - MS_channel k59_981473_1 1128912.GMES_1002 9.23e-44 155.0 28KPJ@1|root,2ZA7P@2|Bacteria,1R6JN@1224|Proteobacteria,1S02Y@1236|Gammaproteobacteria,469Z7@72275|Alteromonadaceae 1236|Gammaproteobacteria S Sulfotransferase domain - - - - - - - - - - - - Sulfotransfer_3 k59_80538_1 158500.BV97_04553 2.72e-33 129.0 COG1629@1|root,COG4771@2|Bacteria,1MWKN@1224|Proteobacteria 1224|Proteobacteria P COG1629 Outer membrane receptor proteins, mostly Fe transport - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_1095451_1 1535422.ND16A_1983 1.05e-16 78.2 COG1733@1|root,COG1733@2|Bacteria 2|Bacteria K regulation of RNA biosynthetic process - - - - - - - - - - - - HxlR k59_418225_1 1122137.AQXF01000001_gene3130 5.43e-106 311.0 2C3PP@1|root,2Z954@2|Bacteria,1MXGR@1224|Proteobacteria,2TS01@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Branched-chain amino acid aminotransferase - - - - - - - - - - - - - k59_418225_2 1122137.AQXF01000001_gene3131 6.08e-189 528.0 COG0115@1|root,COG0115@2|Bacteria,1MVB0@1224|Proteobacteria,2TQR9@28211|Alphaproteobacteria 28211|Alphaproteobacteria EH COG0115 Branched-chain amino acid aminotransferase 4-amino-4-deoxychorismate lyase - - 2.6.1.42 ko:K00826 ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00036,M00119,M00570 R01090,R01214,R02199,R10991 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_4 k59_1379415_1 1229909.NSED_02025 1.93e-39 142.0 COG4742@1|root,arCOG04362@2157|Archaea,41SGE@651137|Thaumarchaeota 651137|Thaumarchaeota K Transcriptional regulator - - - - - - - - - - - - HTH_20,HTH_5 k59_530400_1 1379270.AUXF01000005_gene747 5.14e-91 291.0 COG0542@1|root,COG0542@2|Bacteria,1ZT9Z@142182|Gemmatimonadetes 142182|Gemmatimonadetes O Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE clpB - - ko:K03695 ko04213,map04213 - - - ko00000,ko00001,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N k59_1265333_1 986075.CathTA2_1311 7.39e-30 120.0 COG0111@1|root,COG0111@2|Bacteria,1TSDK@1239|Firmicutes,4HAW5@91061|Bacilli 91061|Bacilli EH Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family ghrA - - - - - - - - - - - 2-Hacid_dh,2-Hacid_dh_C k59_757200_1 1265490.JHVY01000022_gene2374 5.41e-18 87.4 COG0845@1|root,COG0845@2|Bacteria,1MUFW@1224|Proteobacteria,1RQJ9@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family acrA - - ko:K03585 ko01501,ko01503,map01501,map01503 M00646,M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000,ko03036 2.A.6.2,8.A.1.6 - - HlyD_D23 k59_474740_1 395961.Cyan7425_2480 2.72e-80 253.0 COG5361@1|root,COG5361@2|Bacteria,1G49Q@1117|Cyanobacteria,3KFX6@43988|Cyanothece 1117|Cyanobacteria S Protein of unknown function (DUF1254) - - - - - - - - - - - - DUF1214,DUF1254 k59_872769_2 324925.Ppha_2889 6.79e-26 106.0 COG0427@1|root,COG0427@2|Bacteria,1FDQ1@1090|Chlorobi 1090|Chlorobi C PFAM acetyl-CoA hydrolase transferase - - 3.1.2.1 ko:K01067 ko00620,map00620 - R00227 RC00004,RC00012 ko00000,ko00001,ko01000 - - - AcetylCoA_hyd_C,AcetylCoA_hydro k59_419358_1 298654.FraEuI1c_5924 1.17e-31 122.0 COG0715@1|root,COG0715@2|Bacteria 2|Bacteria P thiamine-containing compound biosynthetic process thiY - - ko:K02051 - M00188 - - ko00000,ko00002,ko02000 3.A.1.16,3.A.1.17 - - NMT1 k59_1662211_2 203122.Sde_2264 3.06e-130 382.0 COG0715@1|root,COG0715@2|Bacteria,1MWDN@1224|Proteobacteria,1RPUP@1236|Gammaproteobacteria,465AR@72275|Alteromonadaceae 1236|Gammaproteobacteria P COG0715 ABC-type nitrate sulfonate bicarbonate transport systems, periplasmic components nrtC - - ko:K15576 ko00910,ko02010,map00910,map02010 M00438 - - ko00000,ko00001,ko00002,ko02000 3.A.1.16.1,3.A.1.16.2 - - NMT1_2 k59_1494090_1 420662.Mpe_A1231 0.000129 48.5 COG0810@1|root,COG0810@2|Bacteria,1R65W@1224|Proteobacteria,2W055@28216|Betaproteobacteria,1KNG4@119065|unclassified Burkholderiales 28216|Betaproteobacteria M Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins - - - - - - - - - - - - - k59_1494090_2 396588.Tgr7_0537 9.17e-15 73.2 COG0848@1|root,COG0848@2|Bacteria,1RENY@1224|Proteobacteria,1S3TB@1236|Gammaproteobacteria 1236|Gammaproteobacteria U biopolymer transport protein - - - - - - - - - - - - ExbD k59_814009_1 1562701.BBOF01000012_gene342 3.4e-93 285.0 COG0621@1|root,COG0621@2|Bacteria,1MU7N@1224|Proteobacteria,2VI16@28216|Betaproteobacteria,1K3BG@119060|Burkholderiaceae 28216|Betaproteobacteria J Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 rimO - 2.8.4.4 ko:K14441 - - R10652 RC00003,RC03217 ko00000,ko01000,ko03009 - - - Radical_SAM,TRAM,UPF0004 k59_1550437_1 631362.Thi970DRAFT_03295 2.27e-120 356.0 COG2801@1|root,COG2801@2|Bacteria,1R6TH@1224|Proteobacteria,1RRWS@1236|Gammaproteobacteria,1X2I8@135613|Chromatiales 135613|Chromatiales L Mu transposase, C-terminal - - - - - - - - - - - - HTH_32,Mu-transpos_C,rve k59_364324_1 1042377.AFPJ01000028_gene2158 2.03e-48 175.0 COG2755@1|root,COG2755@2|Bacteria,1MXTS@1224|Proteobacteria,1RTPH@1236|Gammaproteobacteria,46419@72275|Alteromonadaceae 1236|Gammaproteobacteria E Concanavalin A-like lectin/glucanases superfamily - - - - - - - - - - - - Laminin_G_3 k59_1773758_1 449447.MAE_38610 9.63e-12 70.5 COG0001@1|root,COG0500@1|root,COG1020@1|root,COG3321@1|root,COG0001@2|Bacteria,COG1020@2|Bacteria,COG2226@2|Bacteria,COG3321@2|Bacteria,1G25N@1117|Cyanobacteria 1117|Cyanobacteria HQ Acyl transferase domain mcyE - - ko:K16129 ko01054,map01054 - - - ko00000,ko00001,ko01008 - - - AMP-binding,Acyl_transf_1,Aminotran_3,Condensation,KAsynt_C_assoc,Ketoacyl-synt_C,Methyltransf_12,PP-binding,ketoacyl-synt k59_1322683_1 522306.CAP2UW1_0674 5.57e-57 188.0 COG0189@1|root,COG0189@2|Bacteria,1MVUA@1224|Proteobacteria,2VIZ3@28216|Betaproteobacteria,1KPRN@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria H Belongs to the prokaryotic GSH synthase family gshB - 6.3.2.3 ko:K01920 ko00270,ko00480,ko01100,map00270,map00480,map01100 M00118 R00497,R10994 RC00096,RC00141 ko00000,ko00001,ko00002,ko01000 - - - GSH-S_ATP,GSH-S_N k59_982560_2 314254.OA2633_12925 2.25e-67 229.0 COG1629@1|root,COG4771@2|Bacteria,1MUC1@1224|Proteobacteria,2U45M@28211|Alphaproteobacteria,43WS2@69657|Hyphomonadaceae 28211|Alphaproteobacteria P TonB dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_702354_1 1469557.JSWF01000032_gene3258 3.56e-58 191.0 COG0010@1|root,COG0010@2|Bacteria,4NE5W@976|Bacteroidetes,1HWNN@117743|Flavobacteriia 976|Bacteroidetes E Belongs to the arginase family fjo29 - 3.5.3.8 ko:K01479 ko00340,ko01100,map00340,map01100 M00045 R02285 RC00221,RC00681 ko00000,ko00001,ko00002,ko01000 - - - Arginase k59_702354_2 1380600.AUYN01000009_gene1366 1.04e-60 199.0 COG1262@1|root,COG1262@2|Bacteria,4NGY2@976|Bacteroidetes,1HXXN@117743|Flavobacteriia 976|Bacteroidetes S gliding motility-associated lipoprotein GldK gldK - - - - - - - - - - - FGE-sulfatase k59_1606605_1 56780.SYN_00527 1.25e-05 51.2 COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,42NB6@68525|delta/epsilon subdivisions,2WIWE@28221|Deltaproteobacteria,2MQB7@213462|Syntrophobacterales 28221|Deltaproteobacteria O Belongs to the peptidase S1C family degP - 3.4.21.107 ko:K04771 ko01503,ko02020,map01503,map02020 M00728 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 - - - PDZ_2,Trypsin_2 k59_1494122_1 518766.Rmar_1682 2.74e-20 93.2 COG1752@1|root,COG1752@2|Bacteria,4PIMZ@976|Bacteroidetes,1FKC4@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes S Patatin-like phospholipase - - - ko:K07001 - - - - ko00000 - - - Patatin k59_24751_1 5786.XP_003285585.1 2.48e-06 48.1 COG0105@1|root,KOG0888@2759|Eukaryota,3X9BS@554915|Amoebozoa 554915|Amoebozoa F Nucleoside diphosphate kinase - GO:0000003,GO:0000166,GO:0003674,GO:0003824,GO:0004550,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0005856,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006186,GO:0006187,GO:0006412,GO:0006414,GO:0006518,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006996,GO:0007010,GO:0007154,GO:0007165,GO:0007186,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009117,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009151,GO:0009153,GO:0009165,GO:0009182,GO:0009186,GO:0009200,GO:0009202,GO:0009215,GO:0009216,GO:0009262,GO:0009263,GO:0009265,GO:0009394,GO:0009987,GO:0010467,GO:0012505,GO:0016020,GO:0016043,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0017076,GO:0017157,GO:0018130,GO:0019205,GO:0019438,GO:0019538,GO:0019637,GO:0019692,GO:0019954,GO:0023052,GO:0030029,GO:0030036,GO:0030100,GO:0030141,GO:0030554,GO:0031410,GO:0031982,GO:0032553,GO:0032555,GO:0032559,GO:0032879,GO:0032991,GO:0034641,GO:0034645,GO:0034654,GO:0035639,GO:0036094,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045806,GO:0045920,GO:0046066,GO:0046070,GO:0046071,GO:0046385,GO:0046483,GO:0046939,GO:0048519,GO:0048523,GO:0048548,GO:0048550,GO:0050764,GO:0050765,GO:0050789,GO:0050794,GO:0050896,GO:0051046,GO:0051048,GO:0051049,GO:0051051,GO:0051128,GO:0051129,GO:0051716,GO:0055086,GO:0060627,GO:0065007,GO:0071704,GO:0071840,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:0097708,GO:0099503,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903530,GO:1903531,GO:1990904 2.7.4.6 ko:K00940 ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016 M00049,M00050,M00052,M00053 R00124,R00139,R00156,R00330,R00570,R00722,R01137,R01857,R02093,R02326,R02331,R03530,R11894,R11895 RC00002 ko00000,ko00001,ko00002,ko01000,ko04131 - - - NDK k59_24751_2 436308.Nmar_0227 3.26e-39 130.0 COG2075@1|root,arCOG01950@2157|Archaea,41T7M@651137|Thaumarchaeota 651137|Thaumarchaeota J Binds to the 23S rRNA rpl24e - - ko:K02896 ko03010,map03010 M00177,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L24e k59_24751_3 436308.Nmar_0226 2.59e-35 120.0 COG2053@1|root,arCOG04314@2157|Archaea,41ST6@651137|Thaumarchaeota 651137|Thaumarchaeota J Belongs to the eukaryotic ribosomal protein eS28 family rps28e - - ko:K02979 ko03010,map03010 M00177,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S28e k59_757236_1 1121937.AUHJ01000001_gene482 1.9e-76 247.0 COG1138@1|root,COG1138@2|Bacteria,1MUQS@1224|Proteobacteria,1RMY5@1236|Gammaproteobacteria,4649T@72275|Alteromonadaceae 1236|Gammaproteobacteria O COG1138 Cytochrome c biogenesis factor ccmF GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016021,GO:0016043,GO:0017003,GO:0017004,GO:0017006,GO:0018063,GO:0019538,GO:0020037,GO:0022607,GO:0031224,GO:0031226,GO:0034622,GO:0036211,GO:0043170,GO:0043412,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0046906,GO:0048037,GO:0065003,GO:0071704,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564 - ko:K02198 - - - - ko00000,ko02000 9.B.14.1 - - CcmF_C,Cytochrom_C_asm k59_419389_1 1123355.JHYO01000018_gene1646 8.52e-26 112.0 COG3164@1|root,COG3164@2|Bacteria,1MVDY@1224|Proteobacteria,2TSGG@28211|Alphaproteobacteria,36XH6@31993|Methylocystaceae 28211|Alphaproteobacteria S Protein of unknown function MA20_30770 - - - - - - - - - - - AsmA_2,DUF3971 k59_24759_1 1125973.JNLC01000011_gene592 1.8e-91 278.0 COG0673@1|root,COG0673@2|Bacteria,1QSNV@1224|Proteobacteria,2TUMB@28211|Alphaproteobacteria 28211|Alphaproteobacteria S oxidoreductase - - - - - - - - - - - - GFO_IDH_MocA,GFO_IDH_MocA_C k59_1550477_1 497964.CfE428DRAFT_5495 1.47e-44 154.0 2CISN@1|root,2Z7MB@2|Bacteria,46VJC@74201|Verrucomicrobia 74201|Verrucomicrobia S Gluconate 2-dehydrogenase subunit 3 - - - - - - - - - - - - Gluconate_2-dh3 k59_872829_1 357808.RoseRS_3649 1.26e-57 196.0 COG0367@1|root,COG0367@2|Bacteria,2G7R3@200795|Chloroflexi,376WK@32061|Chloroflexia 32061|Chloroflexia E Asparagine synthase - - 6.3.5.4 ko:K01953 ko00250,ko01100,ko01110,map00250,map01100,map01110 - R00578 RC00010 ko00000,ko00001,ko01000,ko01002 - - - Asn_synthase,GATase_7 k59_872829_2 118168.MC7420_591 2e-25 104.0 COG0318@1|root,COG0318@2|Bacteria,1G2H0@1117|Cyanobacteria 1117|Cyanobacteria IQ Acyl-CoA synthetase (AMP-forming) AMP-acid ligase II - - 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding,AMP-binding_C k59_1719353_1 290397.Adeh_0298 1.13e-54 191.0 COG0612@1|root,COG0612@2|Bacteria,1MVST@1224|Proteobacteria,42PZF@68525|delta/epsilon subdivisions,2X5HR@28221|Deltaproteobacteria,2YYCV@29|Myxococcales 28221|Deltaproteobacteria S Insulinase (Peptidase family M16) - - - - - - - - - - - - Peptidase_M16,Peptidase_M16_C k59_137593_1 1414720.CBYM010000018_gene3011 4.1e-08 58.9 COG0551@1|root,COG0551@2|Bacteria,1V93W@1239|Firmicutes,24CEN@186801|Clostridia,36IXA@31979|Clostridiaceae 186801|Clostridia L NERD domain protein - - - - - - - - - - - - NERD,zf-C4_Topoisom k59_137593_2 2340.JV46_26220 5.9e-13 68.2 COG0162@1|root,COG0162@2|Bacteria,1MVUQ@1224|Proteobacteria,1RPKC@1236|Gammaproteobacteria,1J4U5@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) tyrS GO:0003674,GO:0003824,GO:0004812,GO:0004831,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006437,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.1 ko:K01866 ko00970,map00970 M00359,M00360 R02918 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - iJN746.PP_0436 S4,tRNA-synt_1b k59_982588_1 234267.Acid_1428 2.87e-22 103.0 COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,3Y2PK@57723|Acidobacteria 57723|Acidobacteria KLTU WD40 domain protein beta Propeller - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - PD40,Pkinase k59_1210827_1 384765.SIAM614_29521 7.94e-77 239.0 COG0409@1|root,COG0409@2|Bacteria,1MU1F@1224|Proteobacteria,2TSE4@28211|Alphaproteobacteria 28211|Alphaproteobacteria O Belongs to the HypD family hypD - - ko:K04654 - - - - ko00000 - - - HypD k59_1210827_2 384765.SIAM614_29526 0.000128 42.0 COG0298@1|root,COG0298@2|Bacteria,1N76Y@1224|Proteobacteria,2UFCQ@28211|Alphaproteobacteria 28211|Alphaproteobacteria O hydrogenase expression formation protein hypC - - ko:K04653,ko:K04656 - - - - ko00000 - - - HupF_HypC k59_1153704_1 1122137.AQXF01000002_gene423 3.49e-121 368.0 COG1506@1|root,COG1506@2|Bacteria,1P6E1@1224|Proteobacteria,2TRVE@28211|Alphaproteobacteria 28211|Alphaproteobacteria E peptidase S9B dipeptidylpeptidase IV domain protein - - 3.4.14.5 ko:K01278 ko04974,map04974 - - - ko00000,ko00001,ko01000,ko01002,ko04090,ko04147 - - - DPPIV_N,Peptidase_S9 k59_24780_1 1229909.NSED_03265 7.42e-15 73.2 COG2084@1|root,arCOG00247@2157|Archaea,41SI2@651137|Thaumarchaeota 651137|Thaumarchaeota I NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase - - 1.1.1.31 ko:K00020 ko00280,ko01100,map00280,map01100 - R05066 RC00099 ko00000,ko00001,ko01000 - - - NAD_binding_11,NAD_binding_2 k59_24780_2 1229909.NSED_03260 1.24e-95 284.0 COG1028@1|root,arCOG01259@2157|Archaea,41SXY@651137|Thaumarchaeota 651137|Thaumarchaeota I Short-chain dehydrogenase reductase SDR - - 1.1.1.100 ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 k59_872839_1 1049564.TevJSym_ai00210 2.03e-78 255.0 COG0171@1|root,COG0388@1|root,COG0171@2|Bacteria,COG0388@2|Bacteria,1MU9U@1224|Proteobacteria,1RNKA@1236|Gammaproteobacteria,1J4VX@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source nadE - 6.3.1.5,6.3.5.1 ko:K01916,ko:K01950 ko00760,ko01100,map00760,map01100 M00115 R00189,R00257 RC00010,RC00100 ko00000,ko00001,ko00002,ko01000 - - - CN_hydrolase,NAD_synthase k59_872839_2 1415780.JPOG01000001_gene2699 1.01e-72 226.0 COG0074@1|root,COG0074@2|Bacteria,1MUGA@1224|Proteobacteria,1RM7Y@1236|Gammaproteobacteria,1X36R@135614|Xanthomonadales 135614|Xanthomonadales C Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit sucD - 6.2.1.5 ko:K01902 ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374,M00620 R00405,R02404 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000 - - - CoA_binding,Ligase_CoA k59_249933_1 247634.GPB2148_1525 1.57e-63 202.0 COG0247@1|root,COG0247@2|Bacteria,1MWTK@1224|Proteobacteria,1RMVZ@1236|Gammaproteobacteria,1J6K8@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C COG0247 Fe-S oxidoreductase - - - ko:K18928 - - - - ko00000 - - - CCG k59_82029_1 1313172.YM304_21620 1.57e-86 275.0 COG0322@1|root,COG0322@2|Bacteria,2GIS4@201174|Actinobacteria,4CMVA@84992|Acidimicrobiia 84992|Acidimicrobiia L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision uvrC - - ko:K03703 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - GIY-YIG,UVR,UvrC_HhH_N k59_982603_1 675814.VIC_000199 4.42e-60 193.0 COG2095@1|root,COG2095@2|Bacteria,1N689@1224|Proteobacteria,1RPV0@1236|Gammaproteobacteria,1XTFJ@135623|Vibrionales 135623|Vibrionales U UPF0056 membrane protein - - - ko:K05595 - - - - ko00000,ko02000 2.A.95.1 - - MarC k59_1322734_2 869210.Marky_0388 8.28e-07 54.7 COG1426@1|root,COG1426@2|Bacteria,1WI06@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus S PEGA domain - - - ko:K15539 - - - - ko00000 - - - DUF4115,HTH_25,PEGA k59_307641_1 414684.RC1_0865 9.32e-83 263.0 COG1228@1|root,COG1228@2|Bacteria,1MVAF@1224|Proteobacteria,2TTYC@28211|Alphaproteobacteria,2JPFW@204441|Rhodospirillales 204441|Rhodospirillales Q Amidohydrolase family - - - - - - - - - - - - Amidohydro_1 k59_24796_2 675814.VIC_002190 3.61e-27 105.0 COG1011@1|root,COG1011@2|Bacteria,1MVWN@1224|Proteobacteria,1RR0H@1236|Gammaproteobacteria,1XWZA@135623|Vibrionales 135623|Vibrionales S Haloacid dehalogenase-like hydrolase - - 3.8.1.2 ko:K01560 ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120 - R05287 RC00697 ko00000,ko00001,ko01000 - - - HAD_2 k59_589176_1 1121403.AUCV01000005_gene209 4.4e-55 184.0 COG1032@1|root,COG1032@2|Bacteria,1P9J0@1224|Proteobacteria,42MWG@68525|delta/epsilon subdivisions,2WIV5@28221|Deltaproteobacteria,2MI1A@213118|Desulfobacterales 28221|Deltaproteobacteria C PFAM Radical SAM domain protein - - - - - - - - - - - - Radical_SAM k59_1322742_1 1144305.PMI02_00428 9.77e-87 280.0 COG1629@1|root,COG1629@2|Bacteria,COG4771@2|Bacteria,1MV8W@1224|Proteobacteria,2TSUV@28211|Alphaproteobacteria,2JZV0@204457|Sphingomonadales 204457|Sphingomonadales P receptor - - - - - - - - - - - - Plug,TonB_dep_Rec k59_1392365_1 316407.85675968 2.26e-230 643.0 COG2194@1|root,COG2194@2|Bacteria,1MWS7@1224|Proteobacteria,1SYHV@1236|Gammaproteobacteria,3XQZT@561|Escherichia 1236|Gammaproteobacteria S sulfuric ester hydrolase activity yhbX GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016740,GO:0016772,GO:0016776,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044464,GO:0046401,GO:0071704,GO:0071944,GO:1901135,GO:1901137,GO:1901576,GO:1903509 - - - - - - - - - - Sulfatase k59_1105104_1 1096930.L284_18140 1.31e-80 251.0 COG1752@1|root,COG1752@2|Bacteria,1MVHW@1224|Proteobacteria,2TS4V@28211|Alphaproteobacteria,2K3SS@204457|Sphingomonadales 204457|Sphingomonadales S Patatin-like phospholipase - - - ko:K07001 - - - - ko00000 - - - Patatin k59_1105959_1 425104.Ssed_2149 1.66e-11 65.5 COG3005@1|root,COG3005@2|Bacteria,1R4UP@1224|Proteobacteria,1RZUI@1236|Gammaproteobacteria,2QAN2@267890|Shewanellaceae 1236|Gammaproteobacteria C TIGRFAM cytochrome C family protein - - - - - - - - - - - - Paired_CXXCH_1 k59_37278_1 1335757.SPICUR_02435 8.68e-13 67.4 COG0117@1|root,COG1985@1|root,COG0117@2|Bacteria,COG1985@2|Bacteria,1MUWT@1224|Proteobacteria,1RN2M@1236|Gammaproteobacteria,1WVVQ@135613|Chromatiales 135613|Chromatiales H Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate ribD - 1.1.1.193,3.5.4.26 ko:K11752 ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024 M00125 R03458,R03459 RC00204,RC00933 ko00000,ko00001,ko00002,ko01000 - - - RibD_C,dCMP_cyt_deam_1 k59_1221397_1 401053.AciPR4_0106 8.37e-97 299.0 COG0677@1|root,COG0677@2|Bacteria,3Y30B@57723|Acidobacteria,2JIIN@204432|Acidobacteriia 204432|Acidobacteriia M Belongs to the UDP-glucose GDP-mannose dehydrogenase family - - 1.1.1.136 ko:K13015 ko00520,map00520 - R00421 RC00291 ko00000,ko00001,ko01000,ko01005 - - - UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N k59_428230_1 1279038.KB907337_gene290 3.6e-62 206.0 COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,2TR2Z@28211|Alphaproteobacteria,2JQ2N@204441|Rhodospirillales 204441|Rhodospirillales C FAD linked oxidases, C-terminal domain - - 1.1.2.4 ko:K00102 ko00620,map00620 - R00197 RC00044 ko00000,ko00001,ko01000 - - - FAD-oxidase_C,FAD_binding_4 k59_320447_3 59538.XP_005965332.1 4.83e-32 120.0 COG3474@1|root,KOG3453@2759|Eukaryota 2759|Eukaryota C electron transfer activity - - - ko:K08738 ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416 M00595 R10151 RC03151,RC03152 ko00000,ko00001,ko00002 3.D.4.6 - - Cytochrom_C k59_320447_4 591158.SSMG_06597 6.38e-22 96.7 COG1773@1|root,COG3239@1|root,COG1773@2|Bacteria,COG3239@2|Bacteria,2GIWV@201174|Actinobacteria 201174|Actinobacteria I Alkane 1-monooxygenase alkB - 1.14.15.3 ko:K00496 ko00071,ko00930,map00071,map00930 - R01347,R02281,R06945 RC00478 ko00000,ko00001,ko01000 - - - FA_desaturase,Rubredoxin k59_1331484_1 1121285.AUFK01000018_gene664 6.42e-181 535.0 COG0841@1|root,COG0841@2|Bacteria,4NDZG@976|Bacteroidetes,1HX2H@117743|Flavobacteriia,3ZTBU@59732|Chryseobacterium 976|Bacteroidetes V Protein export membrane protein - - - - - - - - - - - - ACR_tran k59_538755_1 1163617.SCD_n01695 9.17e-22 99.8 COG1256@1|root,COG1749@1|root,COG1256@2|Bacteria,COG1749@2|Bacteria,1MV2M@1224|Proteobacteria,2VH02@28216|Betaproteobacteria 28216|Betaproteobacteria N flagellar hook-associated protein flgK - - ko:K02396 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - Flg_bb_rod,Flg_bbr_C k59_538755_2 1502852.FG94_04902 4.47e-06 49.7 COG1705@1|root,COG1705@2|Bacteria,1RJNK@1224|Proteobacteria,2VSWY@28216|Betaproteobacteria,4774E@75682|Oxalobacteraceae 28216|Betaproteobacteria NU Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase flgJ1 - - ko:K02395 - - - - ko00000,ko02035 - - - Glucosaminidase k59_601833_1 1234664.AMRO01000077_gene3432 6.53e-101 306.0 COG3876@1|root,COG3876@2|Bacteria,1VRMG@1239|Firmicutes,4HA8F@91061|Bacilli,1WFX8@129337|Geobacillus 91061|Bacilli S Protein of unknown function (DUF1343) ybbC - - - - - - - - - - - DUF1343 k59_1053423_2 1192759.AKIB01000026_gene2160 1.12e-114 337.0 COG4221@1|root,COG4221@2|Bacteria,1MVYG@1224|Proteobacteria,2TSTP@28211|Alphaproteobacteria,2K8WB@204457|Sphingomonadales 204457|Sphingomonadales S KR domain - - - - - - - - - - - - adh_short k59_885371_1 1336233.JAEH01000008_gene2193 7.13e-58 194.0 COG1228@1|root,COG1228@2|Bacteria,1R6IT@1224|Proteobacteria,1SJV0@1236|Gammaproteobacteria 1236|Gammaproteobacteria Q Amidohydrolase family - - - - - - - - - - - - Amidohydro_1 k59_1444552_1 745411.B3C1_05737 2.33e-53 185.0 COG4805@1|root,COG4805@2|Bacteria,1MUBX@1224|Proteobacteria,1RMT7@1236|Gammaproteobacteria,1J52J@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S protein conserved in bacteria - - - - - - - - - - - - DUF885 k59_653817_1 644801.Psest_3427 3.12e-85 265.0 COG3039@1|root,COG3039@2|Bacteria,1MUVI@1224|Proteobacteria,1RQVT@1236|Gammaproteobacteria,1Z1TJ@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria L COG3666 Transposase and inactivated derivatives - - - - - - - - - - - - DDE_Tnp_1,DDE_Tnp_1_6,DUF772 k59_428261_1 1125863.JAFN01000001_gene3221 1.58e-105 311.0 COG0410@1|root,COG0410@2|Bacteria,1MU4Z@1224|Proteobacteria,42PIG@68525|delta/epsilon subdivisions,2WPPY@28221|Deltaproteobacteria 28221|Deltaproteobacteria E ABC transporter - - - - - - - - - - - - ABC_tran k59_428261_2 187272.Mlg_0191 4.6e-45 153.0 COG4674@1|root,COG4674@2|Bacteria,1MUBR@1224|Proteobacteria,1RM8F@1236|Gammaproteobacteria,1WXAW@135613|Chromatiales 135613|Chromatiales S pfam abc - - - ko:K11962 ko02010,map02010 M00323 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4.4,3.A.1.4.5 - - ABC_tran,BCA_ABC_TP_C k59_1506594_1 316407.85676530 1.13e-99 316.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1SK4F@1236|Gammaproteobacteria,3XMW6@561|Escherichia 1236|Gammaproteobacteria V Part of the tripartite efflux system MdtEF-TolC, which confers resistance to mdtF GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006855,GO:0008150,GO:0015893,GO:0016020,GO:0042221,GO:0042493,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071944 - ko:K18899 - M00697 - - ko00000,ko00002,ko01504,ko02000 2.A.6.2.13 - - ACR_tran k59_714910_1 1121918.ARWE01000001_gene2051 2.95e-89 279.0 COG0661@1|root,COG0661@2|Bacteria,1MU1Z@1224|Proteobacteria,42N87@68525|delta/epsilon subdivisions,2WK1B@28221|Deltaproteobacteria,43S4A@69541|Desulfuromonadales 28221|Deltaproteobacteria S ABC1 family - - - ko:K03688 - - - - ko00000 - - - ABC1,APH k59_262182_1 1379281.AVAG01000029_gene54 1.29e-08 59.7 COG0679@1|root,COG0679@2|Bacteria,1N1X9@1224|Proteobacteria,42R83@68525|delta/epsilon subdivisions,2WN00@28221|Deltaproteobacteria,2MG0S@213115|Desulfovibrionales 28221|Deltaproteobacteria S Membrane transport protein - - - ko:K07088 - - - - ko00000 - - - Mem_trans k59_262182_2 1005058.UMN179_01333 5.2e-06 47.4 COG0196@1|root,COG0196@2|Bacteria,1MV9I@1224|Proteobacteria,1RN44@1236|Gammaproteobacteria,1Y778@135625|Pasteurellales 135625|Pasteurellales H Belongs to the ribF family ribF - 2.7.1.26,2.7.7.2 ko:K11753 ko00740,ko01100,ko01110,map00740,map01100,map01110 M00125 R00161,R00549 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - FAD_syn,Flavokinase k59_1729494_1 1236541.BALL01000044_gene4027 4.73e-45 155.0 2CJ6B@1|root,32S9B@2|Bacteria,1N2I4@1224|Proteobacteria,1S8Z8@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Thermostable hemolysin - - - - - - - - - - - - T_hemolysin k59_1729494_2 400668.Mmwyl1_3829 2.72e-19 89.7 COG1022@1|root,COG1022@2|Bacteria,1MU4D@1224|Proteobacteria,1RPNE@1236|Gammaproteobacteria,1XIUK@135619|Oceanospirillales 135619|Oceanospirillales I AMP-binding enzyme - - - - - - - - - - - - AMP-binding k59_428266_1 262724.TT_C1836 0.000601 44.3 COG2165@1|root,COG2165@2|Bacteria,1WKMD@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus NU Prokaryotic N-terminal methylation motif - - - - - - - - - - - - N_methyl k59_428266_2 1036674.A28LD_1920 2.99e-32 124.0 COG1459@1|root,COG1459@2|Bacteria,1MV4U@1224|Proteobacteria,1RQMI@1236|Gammaproteobacteria,2QFCJ@267893|Idiomarinaceae 1236|Gammaproteobacteria NU Type II secretory pathway mshG - - ko:K02505,ko:K12278 - - - - ko00000,ko02044 - - - T2SSF k59_483634_1 1129794.C427_2779 2.99e-51 187.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,464D9@72275|Alteromonadaceae 1236|Gammaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family mdtB - - ko:K03296 - - - - ko00000 2.A.6.2 - - ACR_tran k59_1053448_1 1415778.JQMM01000001_gene1546 4.95e-152 437.0 COG0148@1|root,COG0148@2|Bacteria,1MU1N@1224|Proteobacteria,1RNQA@1236|Gammaproteobacteria,1J4TX@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria G Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis eno GO:0000015,GO:0000287,GO:0003674,GO:0003824,GO:0004634,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005856,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009986,GO:0009987,GO:0016052,GO:0016053,GO:0016310,GO:0016829,GO:0016835,GO:0016836,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0032991,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042802,GO:0042866,GO:0043167,GO:0043169,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046872,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1902494 4.2.1.11 ko:K01689 ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066 M00001,M00002,M00003,M00346,M00394 R00658 RC00349 ko00000,ko00001,ko00002,ko01000,ko03019,ko04147 - - iPC815.YPO3376 Enolase_C,Enolase_N k59_320505_1 3075.A0A087S9X6 4.88e-06 53.9 COG1184@1|root,KOG1467@2759|Eukaryota,37P4G@33090|Viridiplantae,34HTE@3041|Chlorophyta 3041|Chlorophyta J Belongs to the eIF-2B alpha beta delta subunits family - - - ko:K03680 ko03013,map03013 - - - ko00000,ko00001,ko03012 - - - IF-2B k59_1564021_1 595494.Tola_0919 2.55e-35 135.0 COG4783@1|root,COG4783@2|Bacteria,1MVFV@1224|Proteobacteria,1RP5S@1236|Gammaproteobacteria,1Y3EB@135624|Aeromonadales 135624|Aeromonadales S Functions as both a chaperone and a metalloprotease. Maintains the integrity of the outer membrane by promoting either the assembly or the elimination of outer membrane proteins, depending on their folding state - - - - - - - - - - - - Peptidase_M48,TPR_19 k59_1053455_1 1392490.JHZX01000001_gene471 8.34e-73 232.0 COG3307@1|root,COG3307@2|Bacteria,4NGIS@976|Bacteroidetes,1HYGB@117743|Flavobacteriia 976|Bacteroidetes M O-Antigen ligase - - - - - - - - - - - - Wzy_C k59_601893_1 1229909.NSED_03790 4.71e-116 349.0 COG0277@1|root,arCOG00337@2157|Archaea,41T0E@651137|Thaumarchaeota 651137|Thaumarchaeota C FAD linked - - - - - - - - - - - - FAD-oxidase_C,FAD_binding_4 k59_37365_1 1210046.B277_12456 2.73e-32 122.0 COG0652@1|root,COG0652@2|Bacteria,2GN8G@201174|Actinobacteria,4FG3D@85021|Intrasporangiaceae 201174|Actinobacteria O peptidyl-prolyl cis-trans isomerase - - 5.2.1.8 ko:K03768 - - - - ko00000,ko01000,ko03110 - - - Pro_isomerase k59_428274_1 43989.cce_2244 1.23e-38 144.0 COG0664@1|root,COG2066@1|root,COG0664@2|Bacteria,COG2066@2|Bacteria,1G1IK@1117|Cyanobacteria,3KH5H@43988|Cyanothece 1117|Cyanobacteria E Belongs to the glutaminase family glsA - 3.5.1.2 ko:K01425 ko00220,ko00250,ko00471,ko01100,ko04724,ko04727,ko04964,ko05206,ko05230,map00220,map00250,map00471,map01100,map04724,map04727,map04964,map05206,map05230 - R00256,R01579 RC00010,RC02798 ko00000,ko00001,ko01000 - - - Glutaminase,STAS,cNMP_binding k59_1165220_1 1122137.AQXF01000003_gene2086 1.08e-280 787.0 COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,1MWGR@1224|Proteobacteria,2TUXY@28211|Alphaproteobacteria 28211|Alphaproteobacteria EU peptidase S9 - - - - - - - - - - - - PD40,Peptidase_S9 k59_37372_1 395495.Lcho_3893 4.48e-71 241.0 COG2132@1|root,COG2132@2|Bacteria,1N9H3@1224|Proteobacteria,2VZQA@28216|Betaproteobacteria,1KNDH@119065|unclassified Burkholderiales 28216|Betaproteobacteria Q Multicopper oxidase - - 1.16.3.3 ko:K22349 - - - - ko00000,ko01000 - - - - k59_1274623_1 1144305.PMI02_01203 5.59e-41 149.0 COG0542@1|root,COG0542@2|Bacteria,1MV8B@1224|Proteobacteria,2TQUZ@28211|Alphaproteobacteria,2K0MN@204457|Sphingomonadales 204457|Sphingomonadales O Belongs to the ClpA ClpB family clpA - - ko:K03694 - - - - ko00000,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N k59_1274623_2 1219049.SP5_101_00050 6.38e-05 44.7 COG5509@1|root,COG5509@2|Bacteria,1NG8P@1224|Proteobacteria,2UJB2@28211|Alphaproteobacteria,2K7YT@204457|Sphingomonadales 204457|Sphingomonadales S Protein of unknown function (DUF1192) - - - - - - - - - - - - DUF1192 k59_93094_1 1168065.DOK_12291 5.41e-113 334.0 COG2828@1|root,COG2828@2|Bacteria,1MXVV@1224|Proteobacteria,1RNE6@1236|Gammaproteobacteria,1J5BN@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S protein conserved in bacteria galD GO:0003674,GO:0003824,GO:0006082,GO:0006725,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016054,GO:0016853,GO:0016860,GO:0016863,GO:0017144,GO:0018918,GO:0018958,GO:0019336,GO:0019396,GO:0019439,GO:0019752,GO:0032787,GO:0042537,GO:0042737,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0071704,GO:0072329,GO:1901360,GO:1901361,GO:1901575,GO:1901615,GO:1901616 5.3.2.8 ko:K16514 ko00362,ko01120,map00362,map01120 - R07839 RC02426 ko00000,ko00001,ko01000 - - - PrpF k59_825079_1 1168067.JAGP01000001_gene907 6.44e-12 75.1 COG2203@1|root,COG2206@1|root,COG4191@1|root,COG2203@2|Bacteria,COG2206@2|Bacteria,COG4191@2|Bacteria,1RAQS@1224|Proteobacteria,1S4K4@1236|Gammaproteobacteria 1236|Gammaproteobacteria T domain protein - - - - - - - - - - - - CBS,GAF_2,HD,HD_5,PAS_4,PAS_9 k59_93095_1 1121374.KB891585_gene2295 1.21e-38 135.0 COG3101@1|root,COG3101@2|Bacteria,1MWTG@1224|Proteobacteria,1RNHD@1236|Gammaproteobacteria 1236|Gammaproteobacteria S protein conserved in bacteria yfcM GO:0003674,GO:0003824,GO:0004497,GO:0005488,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016705,GO:0016709,GO:0017185,GO:0018126,GO:0018193,GO:0018205,GO:0019538,GO:0036211,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043687,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0046872,GO:0055114,GO:0071704,GO:0072580,GO:1901260,GO:1901564 - ko:K09906 - - - - ko00000,ko01000,ko03012 - - - EpmC k59_93098_1 1411123.JQNH01000001_gene1603 4.73e-12 67.8 COG2897@1|root,COG2897@2|Bacteria,1MW4B@1224|Proteobacteria,2TR9R@28211|Alphaproteobacteria 28211|Alphaproteobacteria P sulfurtransferase sseA GO:0003674,GO:0003824,GO:0004792,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006725,GO:0006807,GO:0006950,GO:0006979,GO:0007154,GO:0008150,GO:0008152,GO:0009605,GO:0009987,GO:0009991,GO:0016740,GO:0016782,GO:0016783,GO:0016784,GO:0031668,GO:0033554,GO:0034641,GO:0042221,GO:0042262,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046677,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0090304,GO:1901360 2.8.1.1,2.8.1.2 ko:K01011 ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122 - R01931,R03105,R03106 RC00214 ko00000,ko00001,ko01000 - - - Rhodanese k59_1221538_1 685035.ADAE01000018_gene498 5.25e-20 96.3 COG1629@1|root,COG4771@2|Bacteria,1MWKN@1224|Proteobacteria,2U10R@28211|Alphaproteobacteria,2K0G1@204457|Sphingomonadales 204457|Sphingomonadales P receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_320568_1 358823.DF19_20845 4.05e-44 156.0 COG4977@1|root,COG4977@2|Bacteria,2GM0M@201174|Actinobacteria 201174|Actinobacteria K Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain - GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0009405,GO:0010468,GO:0010565,GO:0016020,GO:0019216,GO:0019217,GO:0019222,GO:0031323,GO:0044419,GO:0044464,GO:0050789,GO:0050794,GO:0051704,GO:0060255,GO:0062012,GO:0065007,GO:0071944,GO:0080090 - - - - - - - - - - DJ-1_PfpI,HTH_18 k59_714995_1 644801.Psest_3466 2.41e-46 169.0 COG1368@1|root,COG1368@2|Bacteria,1MVCM@1224|Proteobacteria,1RNJ3@1236|Gammaproteobacteria,1Z2A0@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria M COG1368 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily - - - - - - - - - - - - Sulfatase k59_1671586_1 1096930.L284_20280 1.27e-97 301.0 COG0358@1|root,COG0358@2|Bacteria,1MUHC@1224|Proteobacteria,2TRU2@28211|Alphaproteobacteria,2K0VR@204457|Sphingomonadales 204457|Sphingomonadales L RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication dnaG - - ko:K02316 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - Toprim_4,Toprim_N,zf-CHC2 k59_825097_1 323848.Nmul_A0442 2.44e-28 112.0 COG3705@1|root,COG3705@2|Bacteria,1MWIG@1224|Proteobacteria,2VHVX@28216|Betaproteobacteria,372G2@32003|Nitrosomonadales 28216|Betaproteobacteria E Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine hisZ - - ko:K02502 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R01071 RC02819,RC03200 ko00000,ko00001,ko00002 - - - tRNA-synt_His k59_825097_2 1288494.EBAPG3_3990 2.84e-45 157.0 COG0104@1|root,COG0104@2|Bacteria,1MU5B@1224|Proteobacteria,2VHBR@28216|Betaproteobacteria,372QC@32003|Nitrosomonadales 28216|Betaproteobacteria F Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP purA - 6.3.4.4 ko:K01939 ko00230,ko00250,ko01100,map00230,map00250,map01100 M00049 R01135 RC00458,RC00459 ko00000,ko00001,ko00002,ko01000 - - - Adenylsucc_synt k59_93102_1 391625.PPSIR1_34462 6.98e-49 180.0 COG0768@1|root,COG0768@2|Bacteria,1MUNY@1224|Proteobacteria,42M1T@68525|delta/epsilon subdivisions,2WK0W@28221|Deltaproteobacteria,2YTT3@29|Myxococcales 28221|Deltaproteobacteria M penicillin-binding protein ftsI - 3.4.16.4 ko:K03587 ko00550,ko01501,map00550,map01501 - - - ko00000,ko00001,ko01000,ko01011,ko03036 - - - PASTA,PBP_dimer,Transpeptidase k59_1729557_1 46429.BV95_00314 2.66e-54 182.0 COG0842@1|root,COG0842@2|Bacteria,1MW5R@1224|Proteobacteria,2TU59@28211|Alphaproteobacteria,2K9RY@204457|Sphingomonadales 204457|Sphingomonadales V ABC-2 family transporter protein - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_3 k59_1729557_2 861450.HMPREF0080_00789 3.12e-06 49.3 COG0842@1|root,COG0842@2|Bacteria,1TQG7@1239|Firmicutes,4H2X2@909932|Negativicutes 909932|Negativicutes V ABC-2 type transporter - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_3 k59_320575_1 221103.XP_007845157.1 6.09e-21 95.9 COG2030@1|root,KOG1206@2759|Eukaryota,38D3K@33154|Opisthokonta,3NV6Q@4751|Fungi,3UZIA@5204|Basidiomycota,226AC@155619|Agaricomycetes,3W43V@5338|Agaricales 4751|Fungi Q KR domain - - - ko:K14729 - - - - ko00000,ko01000 - - - MaoC_dehydrat_N,MaoC_dehydratas,SCP2,adh_short k59_1671588_1 1122211.JMLW01000014_gene1135 2.01e-12 75.9 COG1530@1|root,COG1530@2|Bacteria,1MV65@1224|Proteobacteria,1RMDS@1236|Gammaproteobacteria,1XHTN@135619|Oceanospirillales 135619|Oceanospirillales J Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs rne - 3.1.26.12 ko:K08300 ko03018,map03018 M00394 - - ko00000,ko00001,ko00002,ko01000,ko03009,ko03019 - - - RNase_E_G,S1 k59_766195_1 702113.PP1Y_AT8688 2.79e-139 413.0 COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,2TQNY@28211|Alphaproteobacteria,2K15Q@204457|Sphingomonadales 204457|Sphingomonadales KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance - - 2.7.6.5,3.1.7.2 ko:K00951,ko:K01139 ko00230,map00230 - R00336,R00429 RC00002,RC00078 ko00000,ko00001,ko01000,ko03009 - - - ACT_4,HD_4,RelA_SpoT,TGS k59_1564064_1 1265505.ATUG01000001_gene3097 8.36e-15 77.8 COG0745@1|root,COG2204@1|root,COG3852@1|root,COG0745@2|Bacteria,COG2204@2|Bacteria,COG3852@2|Bacteria,1NWAF@1224|Proteobacteria,430TW@68525|delta/epsilon subdivisions 1224|Proteobacteria T Histidine kinase-like ATPases ompR_2 - 2.1.1.80,2.7.13.3,3.1.1.61 ko:K07677,ko:K07679,ko:K13924,ko:K20974 ko02020,ko02025,ko02026,ko02030,ko05133,map02020,map02025,map02026,map02030,map05133 M00474,M00477,M00506,M00820 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 - - - HATPase_c,HisKA,Hpt,PAS_9,Response_reg,Trans_reg_C k59_320587_1 1150469.RSPPHO_00141 3.92e-89 275.0 COG0573@1|root,COG0573@2|Bacteria,1MVKP@1224|Proteobacteria,2TQU1@28211|Alphaproteobacteria,2JQK1@204441|Rhodospirillales 204441|Rhodospirillales P probably responsible for the translocation of the substrate across the membrane pstC - - ko:K02037 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - BPD_transp_1,DUF3708 k59_320587_2 1120953.AUBH01000008_gene291 9.72e-14 73.6 COG0581@1|root,COG0581@2|Bacteria,1MUWB@1224|Proteobacteria,1RPV9@1236|Gammaproteobacteria,46535@72275|Alteromonadaceae 1236|Gammaproteobacteria P COG0581 ABC-type phosphate transport system, permease component pstA - - ko:K02038 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - BPD_transp_1,DUF3333 k59_262245_1 2002.JOEQ01000013_gene5456 2.51e-24 98.2 COG1941@1|root,COG1941@2|Bacteria,2GSPN@201174|Actinobacteria,4EIDA@85012|Streptosporangiales 201174|Actinobacteria C NADH ubiquinone oxidoreductase, 20 Kd subunit - - 1.12.1.2 ko:K18007 - - - - ko00000,ko01000 - - - Oxidored_q6 k59_262245_2 743836.AYNA01000054_gene82 9.55e-41 143.0 COG0543@1|root,COG0543@2|Bacteria,1R6QZ@1224|Proteobacteria,2V487@28211|Alphaproteobacteria,36ZQF@31993|Methylocystaceae 28211|Alphaproteobacteria CH Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B - - - - - - - - - - - - DHODB_Fe-S_bind,NAD_binding_1 k59_1444661_1 95619.PM1_0206615 5.69e-69 228.0 COG0769@1|root,COG0769@2|Bacteria,1MU6P@1224|Proteobacteria,1RMD6@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan murE GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008765,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0030203,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 6.3.2.13 ko:K01928 ko00300,ko00550,map00300,map00550 - R02788 RC00064,RC00090 ko00000,ko00001,ko01000,ko01011 - - iECO103_1326.ECO103_0087,iECO111_1330.ECO111_0088,iECW_1372.ECW_m0084,iEKO11_1354.EKO11_3829,iWFL_1372.ECW_m0084,ic_1306.c0103 Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_601997_1 377629.TERTU_0079 1.19e-104 317.0 COG0843@1|root,COG0843@2|Bacteria,1MU7S@1224|Proteobacteria,1RPC3@1236|Gammaproteobacteria,2PMVQ@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria C Cytochrome C and Quinol oxidase polypeptide I ctaD - 1.9.3.1 ko:K02274 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6 - iJN746.PP_0104 COX1 k59_1053506_1 1267535.KB906767_gene54 1.48e-57 191.0 COG0176@1|root,COG0176@2|Bacteria,3Y6V9@57723|Acidobacteria 57723|Acidobacteria H Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway - - 2.2.1.2 ko:K00616 ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007 R01827 RC00439,RC00604 ko00000,ko00001,ko00002,ko01000 - - - TAL_FSA k59_1165304_1 1116375.VEJY3_16581 1.34e-10 63.2 COG1178@1|root,COG1178@2|Bacteria,1MXZZ@1224|Proteobacteria,1RY3W@1236|Gammaproteobacteria,1XTGS@135623|Vibrionales 135623|Vibrionales P ABC-type Fe3 transport system, permease component - - - ko:K02011 ko02010,map02010 M00190 - - ko00000,ko00001,ko00002,ko02000 3.A.1.10 - - BPD_transp_1 k59_1165304_2 1205680.CAKO01000005_gene3538 1.2e-24 103.0 COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,2TQMJ@28211|Alphaproteobacteria,2JQAD@204441|Rhodospirillales 204441|Rhodospirillales E TOBE domain - - - ko:K02052 ko02024,map02024 M00193 - - ko00000,ko00001,ko00002,ko02000 3.A.1.11 - - ABC_tran,TOBE_2 k59_428329_1 756067.MicvaDRAFT_4632 5.64e-44 163.0 COG2200@1|root,COG2202@1|root,COG2203@1|root,COG5001@1|root,COG2200@2|Bacteria,COG2202@2|Bacteria,COG2203@2|Bacteria,COG5001@2|Bacteria,1G0SY@1117|Cyanobacteria,1H7TU@1150|Oscillatoriales 1117|Cyanobacteria T COGs COG5001 signal transduction protein containing a membrane domain an EAL and a GGDEF domain - - - - - - - - - - - - EAL,GAF,GAF_2,GGDEF,PAS,PAS_3,PAS_9 k59_825142_2 1123228.AUIH01000003_gene833 1.07e-61 191.0 COG0335@1|root,COG0335@2|Bacteria,1RH3A@1224|Proteobacteria,1S5XX@1236|Gammaproteobacteria,1XJT2@135619|Oceanospirillales 135619|Oceanospirillales J This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site rplS - - ko:K02884 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L19 k59_320610_1 1313172.YM304_26040 1.72e-62 199.0 COG0638@1|root,COG0638@2|Bacteria,2GKZ1@201174|Actinobacteria,4CMY5@84992|Acidimicrobiia 84992|Acidimicrobiia O Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation prcA - 3.4.25.1 ko:K03432 ko03050,map03050 M00342,M00343 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03051 - - - Proteasome k59_320610_2 1123065.ATWL01000001_gene471 7.51e-47 160.0 COG0638@1|root,COG0638@2|Bacteria,2GJ60@201174|Actinobacteria 201174|Actinobacteria O Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation prcB GO:0000502,GO:0003674,GO:0003824,GO:0004175,GO:0004298,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005839,GO:0005886,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009405,GO:0009987,GO:0010498,GO:0016020,GO:0016787,GO:0019538,GO:0019774,GO:0019899,GO:0019941,GO:0030163,GO:0032991,GO:0035375,GO:0040007,GO:0043170,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044419,GO:0044424,GO:0044464,GO:0051603,GO:0051704,GO:0070003,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1905368,GO:1905369 3.4.25.1 ko:K03433 ko03050,map03050 M00342,M00343 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03051 - - - Proteasome k59_1221590_1 1280953.HOC_10519 3.8e-41 139.0 COG0346@1|root,COG0346@2|Bacteria,1N1D4@1224|Proteobacteria,2UBYV@28211|Alphaproteobacteria,43Y5Z@69657|Hyphomonadaceae 28211|Alphaproteobacteria E COG0346 Lactoylglutathione lyase and related lyases - - - - - - - - - - - - Glyoxalase k59_1221590_2 471874.PROSTU_02354 1.04e-14 70.5 COG0346@1|root,COG0346@2|Bacteria,1RIQG@1224|Proteobacteria,1S409@1236|Gammaproteobacteria,3Z9BD@586|Providencia 1236|Gammaproteobacteria E glyoxalase - - - - - - - - - - - - Glyoxalase k59_93149_1 1411685.U062_01854 1.23e-40 145.0 COG3278@1|root,COG3278@2|Bacteria,1MU18@1224|Proteobacteria,1RM7I@1236|Gammaproteobacteria,1J4J5@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Belongs to the heme-copper respiratory oxidase family ccoN GO:0003674,GO:0003824,GO:0004129,GO:0005215,GO:0005488,GO:0005506,GO:0005507,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006119,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008144,GO:0008150,GO:0008152,GO:0008324,GO:0009055,GO:0009060,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015002,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015672,GO:0015975,GO:0015980,GO:0015988,GO:0015990,GO:0016020,GO:0016021,GO:0016310,GO:0016491,GO:0016675,GO:0016676,GO:0016705,GO:0017144,GO:0019411,GO:0019637,GO:0019646,GO:0019693,GO:0019825,GO:0020037,GO:0022857,GO:0022890,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0032991,GO:0034220,GO:0034641,GO:0036094,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0045154,GO:0045333,GO:0046034,GO:0046483,GO:0046872,GO:0046906,GO:0046914,GO:0048037,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0055114,GO:0070069,GO:0070469,GO:0070470,GO:0071704,GO:0071944,GO:0072521,GO:0097159,GO:0098655,GO:0098660,GO:0098662,GO:1901135,GO:1901360,GO:1901363,GO:1901564,GO:1902600 1.9.3.1 ko:K00404 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00156 - - ko00000,ko00001,ko00002,ko01000 3.D.4.3 - - COX1 k59_93149_2 1415778.JQMM01000001_gene1469 2.25e-90 268.0 COG2993@1|root,COG2993@2|Bacteria,1MXEY@1224|Proteobacteria,1RPU6@1236|Gammaproteobacteria,1J4Y9@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C COG2993 Cbb3-type cytochrome oxidase, cytochrome c subunit ccoO - - ko:K00405 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00156 - - ko00000,ko00001,ko00002 3.D.4.3 - - FixO k59_1729594_1 436308.Nmar_0684 1.62e-108 321.0 COG1163@1|root,arCOG00358@2157|Archaea,41SAD@651137|Thaumarchaeota 651137|Thaumarchaeota S small GTP-binding protein - - - ko:K06944 - - - - ko00000 - - - MMR_HSR1,MMR_HSR1_Xtn,TGS k59_37477_1 1209072.ALBT01000064_gene1161 8.5e-78 243.0 COG1485@1|root,COG1485@2|Bacteria,1MUUW@1224|Proteobacteria,1RMTJ@1236|Gammaproteobacteria,1FGTR@10|Cellvibrio 1236|Gammaproteobacteria D Reduces the stability of FtsZ polymers in the presence of ATP zapE GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032153,GO:0044424,GO:0044464,GO:0051301 - ko:K06916 - - - - ko00000,ko03036 - - - AFG1_ATPase k59_602018_1 551789.ATVJ01000002_gene2808 2.81e-15 77.8 2A4XY@1|root,30TJR@2|Bacteria,1PDFY@1224|Proteobacteria,2VBJI@28211|Alphaproteobacteria,43ZPB@69657|Hyphomonadaceae 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_991794_1 446462.Amir_1935 2.55e-08 55.1 COG0589@1|root,COG0589@2|Bacteria,2IQPQ@201174|Actinobacteria,4E6RZ@85010|Pseudonocardiales 201174|Actinobacteria T Universal stress protein - - - - - - - - - - - - Usp k59_538877_1 1122137.AQXF01000004_gene1413 1.03e-21 92.0 COG0625@1|root,COG0625@2|Bacteria,1MUN3@1224|Proteobacteria,2TTVR@28211|Alphaproteobacteria 28211|Alphaproteobacteria O Belongs to the GST superfamily - - - ko:K11209 - - - - ko00000,ko01000 - - - GST_C,GST_N,GST_N_2,GST_N_3 k59_538877_2 702113.PP1Y_AT11660 6.74e-46 153.0 COG0625@1|root,COG0625@2|Bacteria,1R6UY@1224|Proteobacteria,2U1WS@28211|Alphaproteobacteria,2K8ZE@204457|Sphingomonadales 204457|Sphingomonadales O Glutathione S-transferase, C-terminal domain - - 2.5.1.18 ko:K00799 ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418 - R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905 RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944 ko00000,ko00001,ko01000,ko02000 1.A.12.2.2,1.A.12.3.2 - - GST_C,GST_N_3 k59_936279_1 316407.85676712 1.36e-115 331.0 COG2165@1|root,COG2165@2|Bacteria,1NP8Q@1224|Proteobacteria,1SGBJ@1236|Gammaproteobacteria 1236|Gammaproteobacteria U general secretion pathway protein gspH - - ko:K02457 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - GspH,N_methyl k59_1790144_1 436308.Nmar_0670 1.93e-40 142.0 COG0031@1|root,arCOG01430@2157|Archaea,41SYM@651137|Thaumarchaeota 651137|Thaumarchaeota E Cysteine synthase - - 2.5.1.47 ko:K12339 ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230 M00021 R00897,R03132,R03601,R04859 RC00020,RC02814,RC02821,RC02876 ko00000,ko00001,ko00002,ko01000 - - - PALP k59_1283754_1 1279017.AQYJ01000022_gene2606 4.21e-60 193.0 29B18@1|root,2ZY02@2|Bacteria,1REMG@1224|Proteobacteria,1S4B1@1236|Gammaproteobacteria,46AUF@72275|Alteromonadaceae 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_385645_1 1123368.AUIS01000031_gene1431 3.26e-75 235.0 COG0075@1|root,COG0075@2|Bacteria,1MWHJ@1224|Proteobacteria,1RMNR@1236|Gammaproteobacteria 1236|Gammaproteobacteria E Serine-pyruvate aminotransferase archaeal aspartate aminotransferase pucG - 2.6.1.44,2.6.1.45,2.6.1.51 ko:K00830 ko00250,ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko04146,map00250,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200,map04146 M00346,M00532 R00369,R00372,R00585,R00588 RC00006,RC00008,RC00018 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_5 k59_774570_1 926569.ANT_27120 3.1e-51 184.0 COG0574@1|root,COG0574@2|Bacteria 2|Bacteria G Belongs to the PEP-utilizing enzyme family - - 2.7.9.2 ko:K01007 ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200 M00173,M00374 R00199 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - PPDK_N k59_270949_1 199310.c4607 1.54e-53 169.0 COG0071@1|root,COG0071@2|Bacteria,1RH2X@1224|Proteobacteria,1S6WS@1236|Gammaproteobacteria,3XPM8@561|Escherichia 1236|Gammaproteobacteria O Associates with aggregated proteins, together with IbpB, to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress. Aggregated proteins bound to the IbpAB complex are more efficiently refolded and reactivated by the ATP-dependent chaperone systems ClpB and DnaK DnaJ GrpE. Its activity is ATP- independent ibpA GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0042802,GO:0044424,GO:0044444,GO:0044464,GO:0050896 - ko:K04080 - - - - ko00000,ko03110 - - - HSP20 k59_894203_1 317025.Tcr_1159 1.77e-33 131.0 COG0243@1|root,COG1251@1|root,COG0243@2|Bacteria,COG1251@2|Bacteria,1NS3T@1224|Proteobacteria,1RMWN@1236|Gammaproteobacteria,4603Y@72273|Thiotrichales 72273|Thiotrichales C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - - ko:K00372 ko00910,ko01120,map00910,map01120 M00531 R00798,R01106 RC02812 ko00000,ko00001,ko00002,ko01000 - - - Fer2_BFD,Molybdop_Fe4S4,Molybdopterin,Molydop_binding k59_329026_1 1121912.AUHD01000007_gene547 4.53e-100 298.0 COG1577@1|root,COG1577@2|Bacteria,4NDYJ@976|Bacteroidetes,1HX9R@117743|Flavobacteriia 976|Bacteroidetes I mevalonate kinase mvaK - 2.7.1.36 ko:K00869 ko00900,ko01100,ko01110,ko01130,ko04146,map00900,map01100,map01110,map01130,map04146 M00095 R02245 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - GHMP_kinases_C,GHMP_kinases_N k59_833433_1 1232683.ADIMK_4139 4.31e-257 741.0 COG1305@1|root,COG4196@1|root,COG1305@2|Bacteria,COG4196@2|Bacteria,1MVAG@1224|Proteobacteria,1RMX2@1236|Gammaproteobacteria,464EZ@72275|Alteromonadaceae 1236|Gammaproteobacteria E Putative amidoligase enzyme (DUF2126) IV02_11925 - - - - - - - - - - - Bact_transglu_N,DUF2126,Transglut_core k59_385651_1 498848.TaqDRAFT_4068 1.42e-72 229.0 COG4663@1|root,COG4663@2|Bacteria,1WJ6R@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus Q Part of the tripartite ATP-independent periplasmic (TRAP) transport system - - - - - - - - - - - - DctP,TAT_signal k59_662975_1 1042377.AFPJ01000007_gene1905 3.14e-137 402.0 COG0057@1|root,COG0057@2|Bacteria,1MZE4@1224|Proteobacteria,1RMSI@1236|Gammaproteobacteria,465BD@72275|Alteromonadaceae 1236|Gammaproteobacteria G Belongs to the glyceraldehyde-3-phosphate dehydrogenase family gap - 1.2.1.12 ko:K00134 ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01061 RC00149 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - Gp_dh_C,Gp_dh_N k59_774577_1 316407.4062340 2.08e-210 582.0 COG0391@1|root,COG0391@2|Bacteria,1NW3K@1224|Proteobacteria,1RQP9@1236|Gammaproteobacteria,3XPC9@561|Escherichia 1236|Gammaproteobacteria S Required for morphogenesis under gluconeogenic growth conditions ybhK - - - - - - - - - - - UPF0052 k59_1572606_2 745411.B3C1_06964 1.78e-08 60.5 COG1360@1|root,COG1360@2|Bacteria,1MU4S@1224|Proteobacteria,1S294@1236|Gammaproteobacteria,1J60E@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria N Flagellar motor protein motB - - ko:K02557 ko02030,ko02040,map02030,map02040 - - - ko00000,ko00001,ko02000,ko02035 1.A.30.1 - - MotB_plug,OmpA k59_1453566_1 1229909.NSED_02230 1.21e-28 108.0 arCOG08684@1|root,arCOG08684@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_894227_1 565045.NOR51B_103 4.76e-30 122.0 COG4773@1|root,COG4773@2|Bacteria,1QTXJ@1224|Proteobacteria,1T2BS@1236|Gammaproteobacteria,1J9KJ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P COG1629 Outer membrane receptor proteins, mostly Fe transport - - - - - - - - - - - - Plug,TonB_dep_Rec k59_436739_1 267608.RSc2805 2.95e-71 240.0 COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,2VJIV@28216|Betaproteobacteria,1K1JU@119060|Burkholderiaceae 28216|Betaproteobacteria F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides nrdA GO:0000166,GO:0003674,GO:0003824,GO:0004748,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005971,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009262,GO:0009263,GO:0009987,GO:0016491,GO:0016725,GO:0016728,GO:0018130,GO:0019438,GO:0019637,GO:0032991,GO:0034641,GO:0034654,GO:0036094,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046483,GO:0055086,GO:0055114,GO:0061731,GO:0071704,GO:0090407,GO:0097159,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902494,GO:1990204 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - ATP-cone,Ribonuc_red_lgC,Ribonuc_red_lgN k59_1173603_1 592316.Pat9b_3911 2.17e-64 199.0 COG0756@1|root,COG0756@2|Bacteria,1RA7P@1224|Proteobacteria,1S233@1236|Gammaproteobacteria,3VZ17@53335|Pantoea 1236|Gammaproteobacteria F This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA dut GO:0000166,GO:0000287,GO:0001882,GO:0001884,GO:0002134,GO:0003674,GO:0003824,GO:0004170,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006220,GO:0006221,GO:0006226,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009141,GO:0009143,GO:0009147,GO:0009149,GO:0009157,GO:0009162,GO:0009165,GO:0009166,GO:0009176,GO:0009177,GO:0009200,GO:0009204,GO:0009211,GO:0009213,GO:0009219,GO:0009221,GO:0009223,GO:0009262,GO:0009263,GO:0009264,GO:0009265,GO:0009394,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019103,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0022607,GO:0032549,GO:0032551,GO:0032553,GO:0032557,GO:0032991,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046078,GO:0046080,GO:0046081,GO:0046385,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0046872,GO:0047429,GO:0051259,GO:0051260,GO:0055086,GO:0065003,GO:0070206,GO:0070207,GO:0071704,GO:0071840,GO:0072527,GO:0072528,GO:0072529,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901136,GO:1901137,GO:1901265,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576 3.6.1.23 ko:K01520 ko00240,ko00983,ko01100,map00240,map00983,map01100 M00053 R02100,R11896 RC00002 ko00000,ko00001,ko00002,ko01000,ko03400 - - - dUTPase k59_1173603_2 1123261.AXDW01000016_gene3041 3.99e-15 76.3 COG0452@1|root,COG0452@2|Bacteria,1MVQP@1224|Proteobacteria,1RMKQ@1236|Gammaproteobacteria,1X3EH@135614|Xanthomonadales 135614|Xanthomonadales H Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine dfp - 4.1.1.36,6.3.2.5 ko:K13038 ko00770,ko01100,map00770,map01100 M00120 R03269,R04231 RC00064,RC00090,RC00822 ko00000,ko00001,ko00002,ko01000 - - - DFP,Flavoprotein k59_1453578_1 1123037.AUDE01000015_gene2648 9.27e-96 300.0 COG3968@1|root,COG3968@2|Bacteria,4NG2B@976|Bacteroidetes,1HWKZ@117743|Flavobacteriia 976|Bacteroidetes S glutamine synthetase glnA - 6.3.1.2 ko:K01915 ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 - R00253 RC00010,RC02798 ko00000,ko00001,ko01000,ko04147 - - - GSIII_N,Gln-synt_C k59_436749_1 452637.Oter_2604 6.05e-42 159.0 COG2202@1|root,COG4191@1|root,COG2202@2|Bacteria,COG4191@2|Bacteria,46TZW@74201|Verrucomicrobia,3K9EP@414999|Opitutae 74201|Verrucomicrobia T ATP-binding region ATPase domain protein - - - - - - - - - - - - HATPase_c,PAS_4 k59_436749_2 1333998.M2A_2637 6.2e-50 174.0 COG0318@1|root,COG0318@2|Bacteria,1MUMC@1224|Proteobacteria,2TR96@28211|Alphaproteobacteria,4BRTT@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria IQ AMP-binding enzyme C-terminal domain alkK - 6.2.1.44,6.2.1.48 ko:K00666,ko:K02182,ko:K20034 ko00920,map00920 - R10820 RC00004,RC00014 ko00000,ko00001,ko01000,ko01004 - - - AMP-binding,AMP-binding_C k59_1402805_1 1168065.DOK_18915 3.36e-12 68.2 COG1538@1|root,COG1538@2|Bacteria,1MWCJ@1224|Proteobacteria,1RQQV@1236|Gammaproteobacteria,1J52S@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria MU COG1538 Outer membrane protein tolC - - ko:K12340 ko01501,ko01503,ko02020,ko03070,ko04626,ko05133,map01501,map01503,map02020,map03070,map04626,map05133 M00325,M00326,M00339,M00571,M00575,M00646,M00647,M00696,M00697,M00709,M00720,M00821 - - ko00000,ko00001,ko00002,ko01504,ko02000,ko02044 1.B.17,2.A.6.2 - - OEP k59_1402805_2 247633.GP2143_10377 7.27e-12 64.3 COG0494@1|root,COG0494@2|Bacteria,1RDMW@1224|Proteobacteria,1RPZV@1236|Gammaproteobacteria,1J63J@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes nudF GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0019144,GO:0043167,GO:0043169,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0047631,GO:0050896 3.6.1.13 ko:K01515 ko00230,map00230 - R01054 RC00002 ko00000,ko00001,ko01000 - - iECP_1309.ECP_3126 NUDIX k59_894269_1 69395.JQLZ01000002_gene1361 2.26e-80 267.0 COG1629@1|root,COG4206@1|root,COG4206@2|Bacteria,COG4771@2|Bacteria,1MU9K@1224|Proteobacteria,2TTN6@28211|Alphaproteobacteria,2KHST@204458|Caulobacterales 204458|Caulobacterales P TonB dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_1680523_1 349521.HCH_02510 2.2e-103 314.0 COG0659@1|root,COG0659@2|Bacteria,1MVWV@1224|Proteobacteria,1RMCN@1236|Gammaproteobacteria,1XHA7@135619|Oceanospirillales 135619|Oceanospirillales P Sulfate permease and related transporters (MFS superfamily) - - - ko:K03321 - - - - ko00000,ko02000 2.A.53.3 - - STAS,Sulfate_transp k59_1680523_2 1042377.AFPJ01000010_gene1450 1.46e-20 89.7 COG0589@1|root,COG0589@2|Bacteria,1PAFP@1224|Proteobacteria,1RSCS@1236|Gammaproteobacteria,465CE@72275|Alteromonadaceae 1236|Gammaproteobacteria T COG0589 Universal stress protein UspA and related nucleotide-binding proteins - - - - - - - - - - - - Usp k59_492386_1 330214.NIDE1311 2.02e-97 287.0 COG0087@1|root,COG0087@2|Bacteria,3J0HP@40117|Nitrospirae 40117|Nitrospirae J One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit rplC - - ko:K02906 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L3 k59_155991_1 292459.STH3183 1.71e-20 90.1 COG1521@1|root,COG1521@2|Bacteria,1TR0X@1239|Firmicutes,248PX@186801|Clostridia 186801|Clostridia F Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis coaX - 2.7.1.33 ko:K03525 ko00770,ko01100,map00770,map01100 M00120 R02971,R03018,R04391 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - Pan_kinase k59_155991_2 644548.SCNU_14084 8.87e-14 73.2 COG1190@1|root,COG1190@2|Bacteria,2GKE0@201174|Actinobacteria,4GBTZ@85026|Gordoniaceae 201174|Actinobacteria J tRNA synthetases class II (D, K and N) lysS GO:0008150,GO:0040007 6.1.1.6 ko:K04567 ko00970,map00970 M00359,M00360 R03658 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_2,tRNA_anti-codon k59_155992_1 1121374.KB891592_gene2902 9.08e-23 98.6 COG4773@1|root,COG4773@2|Bacteria,1QTXJ@1224|Proteobacteria,1T2BS@1236|Gammaproteobacteria 1236|Gammaproteobacteria P COG1629 Outer membrane receptor proteins, mostly Fe transport - - - - - - - - - - - - Plug,TonB_dep_Rec k59_155992_2 1288298.rosmuc_03348 5.77e-40 144.0 COG0659@1|root,COG0659@2|Bacteria,1MVWV@1224|Proteobacteria,2TUH6@28211|Alphaproteobacteria,46NWV@74030|Roseovarius 28211|Alphaproteobacteria P COG0659 Sulfate permease and related transporters (MFS superfamily) - - - ko:K03321 - - - - ko00000,ko02000 2.A.53.3 - - STAS,Sulfate_transp k59_1572652_1 1215114.BBIU01000004_gene508 4.48e-07 50.8 COG0194@1|root,COG0194@2|Bacteria,1MW92@1224|Proteobacteria,1RN09@1236|Gammaproteobacteria 1236|Gammaproteobacteria F Essential for recycling GMP and indirectly, cGMP gmk GO:0003674,GO:0003824,GO:0004385,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009126,GO:0009132,GO:0009135,GO:0009150,GO:0009161,GO:0009165,GO:0009167,GO:0009179,GO:0009185,GO:0009259,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0042278,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046037,GO:0046128,GO:0046483,GO:0046710,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901576,GO:1901657 2.7.4.8 ko:K00942 ko00230,ko01100,map00230,map01100 M00050 R00332,R02090 RC00002 ko00000,ko00001,ko00002,ko01000 - - iAPECO1_1312.APECO1_2813,iPC815.YPO0040,iSBO_1134.SBO_3729,iSFV_1184.SFV_3881,iSFxv_1172.SFxv_4016,iUTI89_1310.UTI89_C4193 Guanylate_kin k59_1572652_2 314278.NB231_06091 3.15e-48 166.0 COG1561@1|root,COG1561@2|Bacteria,1MWRA@1224|Proteobacteria,1RMAB@1236|Gammaproteobacteria,1WX83@135613|Chromatiales 135613|Chromatiales S PFAM YicC-like - - - - - - - - - - - - DUF1732,YicC_N k59_1114834_1 1304275.C41B8_11553 1.49e-150 441.0 COG3425@1|root,COG3425@2|Bacteria,1MU4K@1224|Proteobacteria,1S16F@1236|Gammaproteobacteria 1236|Gammaproteobacteria I synthase - - 2.3.3.10 ko:K01641,ko:K15311 ko00072,ko00280,ko00650,ko00900,ko01100,ko01110,ko01130,map00072,map00280,map00650,map00900,map01100,map01110,map01130 M00088,M00095 R01978 RC00004,RC00503 ko00000,ko00001,ko00002,ko01000,ko01008 - - - HMG_CoA_synt_C,HMG_CoA_synt_N k59_1114834_2 1479237.JMLY01000001_gene3299 1.52e-45 153.0 2CD0I@1|root,32RWS@2|Bacteria,1N0MC@1224|Proteobacteria,1SABW@1236|Gammaproteobacteria,46827@72275|Alteromonadaceae 1236|Gammaproteobacteria S Domain of unknown function (DUF4399) - - - - - - - - - - - - DUF4399 k59_945017_1 1229909.NSED_01615 1.46e-80 252.0 COG1032@1|root,arCOG01357@2157|Archaea,41S86@651137|Thaumarchaeota 651137|Thaumarchaeota C Radical SAM - - - - - - - - - - - - Radical_SAM k59_945017_2 436308.Nmar_0335 2.48e-35 122.0 arCOG06055@1|root,arCOG06055@2157|Archaea,41SQ3@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1283857_1 335283.Neut_2288 2.6e-50 162.0 COG2154@1|root,COG2154@2|Bacteria,1RH99@1224|Proteobacteria,2WFUX@28216|Betaproteobacteria 28216|Betaproteobacteria H pterin-4-alpha-carbinolamine dehydratase - - 4.2.1.96 ko:K01724 ko00790,map00790 - R04734 RC01208 ko00000,ko00001,ko01000,ko04147 - - - Pterin_4a k59_385729_1 391735.Veis_0632 7.31e-32 125.0 COG0438@1|root,COG1216@1|root,COG2227@1|root,COG0438@2|Bacteria,COG1216@2|Bacteria,COG2227@2|Bacteria,1QP7Y@1224|Proteobacteria,2VMI5@28216|Betaproteobacteria,4AD1A@80864|Comamonadaceae 28216|Betaproteobacteria HM PFAM Glycosyl transferase, family 2 - - - - - - - - - - - - Glyco_tranf_2_3,Glyco_trans_1_4,Glycos_transf_2,Methyltransf_23 k59_894298_1 1121423.JONT01000008_gene754 9.25e-18 87.4 COG0458@1|root,COG0458@2|Bacteria,1UIGF@1239|Firmicutes,25EMV@186801|Clostridia 186801|Clostridia EF ATP-grasp domain - - 6.3.5.5 ko:K01955 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - - ATP-grasp_3 k59_833516_1 1205753.A989_06773 1.8e-09 63.9 COG1629@1|root,COG4771@2|Bacteria,1MW7D@1224|Proteobacteria,1RNET@1236|Gammaproteobacteria,1X3EK@135614|Xanthomonadales 135614|Xanthomonadales P receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_833516_2 1122137.AQXF01000004_gene1627 1.89e-67 206.0 COG3695@1|root,COG3695@2|Bacteria,1PZ1R@1224|Proteobacteria,2UWVB@28211|Alphaproteobacteria 28211|Alphaproteobacteria L 6-O-methylguanine DNA methyltransferase, DNA binding domain - - - - - - - - - - - - DNA_binding_1 k59_1790253_1 395493.BegalDRAFT_1579 1.99e-28 119.0 COG0457@1|root,COG0457@2|Bacteria,1R50I@1224|Proteobacteria,1RSP6@1236|Gammaproteobacteria,462D9@72273|Thiotrichales 72273|Thiotrichales S Tetratricopeptide repeat - - - - - - - - - - - - - k59_774644_1 685035.ADAE01000008_gene2953 3.9e-10 60.8 COG1261@1|root,COG1261@2|Bacteria,1PM4C@1224|Proteobacteria,2TRUS@28211|Alphaproteobacteria,2K6AN@204457|Sphingomonadales 204457|Sphingomonadales NO Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly - - - ko:K02386 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - ChapFlgA k59_774644_2 685778.AORL01000009_gene3318 1.13e-41 144.0 COG4786@1|root,COG4786@2|Bacteria,1MVMA@1224|Proteobacteria,2TRR4@28211|Alphaproteobacteria,2K1WG@204457|Sphingomonadales 204457|Sphingomonadales N flagellar basal-body rod protein FlgG - - - ko:K02392 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - Flg_bb_rod,Flg_bbr_C k59_436798_1 1397527.Q670_06270 3.2e-57 190.0 COG2041@1|root,COG2041@2|Bacteria,1MUW0@1224|Proteobacteria,1RQ2J@1236|Gammaproteobacteria,1XHX5@135619|Oceanospirillales 135619|Oceanospirillales C Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide msrP - - ko:K07147 - - - - ko00000,ko01000 - - - Oxidored_molyb k59_436798_2 998088.B565_1037 5.16e-31 120.0 COG3724@1|root,COG3724@2|Bacteria,1MUJV@1224|Proteobacteria,1RNSS@1236|Gammaproteobacteria,1Y3ZM@135624|Aeromonadales 135624|Aeromonadales E Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2) astB - 3.5.3.23 ko:K01484 ko00330,ko01100,map00330,map01100 - R04189 RC00024 ko00000,ko00001,ko01000 - - - AstB k59_436803_1 582515.KR51_00037200 2.1e-41 147.0 COG3385@1|root,COG3385@2|Bacteria,1G4J6@1117|Cyanobacteria 1117|Cyanobacteria L PFAM Transposase DDE domain - - - - - - - - - - - - DDE_Tnp_1 k59_1283896_1 114615.BRADO6021 1.64e-82 259.0 COG3135@1|root,COG3135@2|Bacteria,1MUS1@1224|Proteobacteria,2TUEM@28211|Alphaproteobacteria,3JZ3J@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria Q Benzoate membrane transport protein benE - - ko:K05782 - - - - ko00000,ko02000 2.A.46.1 - - BenE k59_436810_1 158500.BV97_03566 1.96e-73 242.0 COG1256@1|root,COG1256@2|Bacteria,1MV2M@1224|Proteobacteria,2TV1B@28211|Alphaproteobacteria,2K0PJ@204457|Sphingomonadales 204457|Sphingomonadales N Flagellar basal body rod FlgEFG protein C-terminal - - - ko:K02396 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - Flg_bb_rod,Flg_bbr_C k59_1625495_1 1197477.IA57_10060 6.54e-135 394.0 COG0516@1|root,COG0517@1|root,COG0516@2|Bacteria,COG0517@2|Bacteria,4NDXQ@976|Bacteroidetes,1HWYC@117743|Flavobacteriia 976|Bacteroidetes F Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth guaB - 1.1.1.205 ko:K00088 ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 M00050 R01130,R08240 RC00143,RC02207 ko00000,ko00001,ko00002,ko01000,ko04147 - - - CBS,IMPDH k59_492436_1 396588.Tgr7_1268 7.19e-68 213.0 COG2181@1|root,COG2181@2|Bacteria,1QQCT@1224|Proteobacteria,1S05R@1236|Gammaproteobacteria,1WXBW@135613|Chromatiales 135613|Chromatiales C nitrate reductase activity - - - - - - - - - - - - - k59_610778_1 270374.MELB17_10333 3.42e-12 68.2 COG0583@1|root,COG0583@2|Bacteria,1MX2A@1224|Proteobacteria,1RQ5Y@1236|Gammaproteobacteria,46BI8@72275|Alteromonadaceae 1236|Gammaproteobacteria K Bacterial regulatory helix-turn-helix protein, lysR family - - - - - - - - - - - - HTH_1,LysR_substrate k59_101507_1 1123278.KB893598_gene2678 5.04e-97 310.0 COG0610@1|root,COG0610@2|Bacteria,4NFJ8@976|Bacteroidetes,47K4E@768503|Cytophagia 976|Bacteroidetes V Subunit R is required for both nuclease and ATPase activities, but not for modification hsdR - 3.1.21.3 ko:K01153 - - - - ko00000,ko01000,ko02048 - - - EcoR124_C,HSDR_N,ResIII k59_1625498_2 1430440.MGMSRv2_3079 6.55e-16 85.1 COG1352@1|root,COG2201@1|root,COG3829@1|root,COG4717@1|root,COG5001@1|root,COG1352@2|Bacteria,COG2201@2|Bacteria,COG3829@2|Bacteria,COG4717@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2TZTY@28211|Alphaproteobacteria 28211|Alphaproteobacteria NT Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) - - 2.1.1.80,3.1.1.61 ko:K13924 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko02022,ko02035 - - - - k59_436816_1 856793.MICA_79 1.38e-47 166.0 COG0438@1|root,COG0438@2|Bacteria,1MUTA@1224|Proteobacteria,2TSPN@28211|Alphaproteobacteria,4BPD6@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria M Glycosyl transferases group 1 capM - - - - - - - - - - - Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1 k59_436816_2 1089551.KE386572_gene1808 3.4e-13 68.9 COG0859@1|root,COG0859@2|Bacteria,1MXA2@1224|Proteobacteria,2TUTN@28211|Alphaproteobacteria,4BTCW@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria M Glycosyltransferase family 9 (heptosyltransferase) - - - - - - - - - - - - Glyco_transf_9 k59_833557_1 1453501.JELR01000002_gene1254 8.46e-90 267.0 COG5405@1|root,COG5405@2|Bacteria,1MVF2@1224|Proteobacteria,1RP7P@1236|Gammaproteobacteria,4643Y@72275|Alteromonadaceae 1236|Gammaproteobacteria O Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery hslV GO:0000166,GO:0000287,GO:0000502,GO:0003674,GO:0003824,GO:0004175,GO:0004298,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009266,GO:0009376,GO:0009408,GO:0009628,GO:0009987,GO:0016043,GO:0016787,GO:0017076,GO:0019538,GO:0019904,GO:0022607,GO:0030163,GO:0030554,GO:0031597,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0034214,GO:0035639,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046872,GO:0050896,GO:0051259,GO:0051603,GO:0065003,GO:0070003,GO:0070011,GO:0071704,GO:0071840,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1904949,GO:1905368,GO:1905369 3.4.25.2 ko:K01419 - - - - ko00000,ko01000,ko01002 - - - Proteasome k59_663044_1 13690.CP98_00933 1.18e-73 234.0 COG0477@1|root,COG2814@2|Bacteria,1QTX0@1224|Proteobacteria,2TUM5@28211|Alphaproteobacteria,2K1MY@204457|Sphingomonadales 204457|Sphingomonadales EGP COG0477 Permeases of the major facilitator superfamily - - - - - - - - - - - - MFS_3 k59_1680622_2 1051646.VITU9109_09282 1.29e-37 131.0 COG2050@1|root,COG2050@2|Bacteria,1RBPE@1224|Proteobacteria,1SCN1@1236|Gammaproteobacteria,1XXCQ@135623|Vibrionales 135623|Vibrionales Q Thioesterase superfamily - - - - - - - - - - - - 4HBT k59_1680623_1 1217705.F900_01437 1.29e-15 81.3 COG2199@1|root,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria,1RMA9@1236|Gammaproteobacteria,3NK89@468|Moraxellaceae 1236|Gammaproteobacteria T diguanylate cyclase - - 2.7.7.65 ko:K11444 ko02020,ko02025,map02020,map02025 M00509 - - ko00000,ko00001,ko00002,ko01000,ko02022 - - - GGDEF,Response_reg k59_610789_1 1123054.KB907733_gene3394 1.01e-95 309.0 COG1629@1|root,COG1629@2|Bacteria,1MWTT@1224|Proteobacteria,1RRQ9@1236|Gammaproteobacteria 1236|Gammaproteobacteria P COG1629 Outer membrane receptor proteins, mostly Fe transport - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - OMP_b-brl_3,Plug,TonB_dep_Rec k59_1515306_1 1227487.C474_12601 1.71e-27 114.0 arCOG01637@1|root,arCOG01637@2157|Archaea,2XVNY@28890|Euryarchaeota,23UJF@183963|Halobacteria 183963|Halobacteria Q Methyltransferase type 12 - - - - - - - - - - - - Methyltransf_31 k59_385792_1 392500.Swoo_1938 4.83e-22 94.7 COG2128@1|root,COG2128@2|Bacteria,1PC51@1224|Proteobacteria,1RS2U@1236|Gammaproteobacteria,2QDAB@267890|Shewanellaceae 1236|Gammaproteobacteria S Carboxymuconolactone decarboxylase family - - - - - - - - - - - - CMD k59_1625518_1 1122929.KB908215_gene855 2.07e-62 197.0 COG3090@1|root,COG3090@2|Bacteria,1RJY4@1224|Proteobacteria,2U949@28211|Alphaproteobacteria 28211|Alphaproteobacteria G Tripartite ATP-independent periplasmic transporters, DctQ component - - - - - - - - - - - - DctQ k59_724226_1 290397.Adeh_3989 1.03e-15 81.3 COG2271@1|root,COG2271@2|Bacteria,1MWYR@1224|Proteobacteria,42RD4@68525|delta/epsilon subdivisions,2WN11@28221|Deltaproteobacteria,2YU83@29|Myxococcales 28221|Deltaproteobacteria G Organic Anion Transporter Polypeptide (OATP) family - - - - - - - - - - - - MFS_1 k59_725518_1 396588.Tgr7_0274 2.24e-41 156.0 29DE2@1|root,300BX@2|Bacteria,1NC7M@1224|Proteobacteria,1SFWA@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_775886_1 1122137.AQXF01000006_gene881 5.55e-17 79.0 COG1344@1|root,COG1344@2|Bacteria,1NSHZ@1224|Proteobacteria,2TRS6@28211|Alphaproteobacteria 28211|Alphaproteobacteria N Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella - - - ko:K02397 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - Flagellin_C,Flagellin_N k59_775886_2 1122137.AQXF01000006_gene882 1.68e-61 207.0 COG1256@1|root,COG1256@2|Bacteria,1MV2M@1224|Proteobacteria,2TV1B@28211|Alphaproteobacteria 28211|Alphaproteobacteria N flagellar hook-associated protein flgK - - ko:K02396 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - Flg_bb_rod,Flg_bbr_C k59_1116278_2 330214.NIDE0236 6.39e-72 218.0 COG0838@1|root,COG0838@2|Bacteria 2|Bacteria C NADH dehydrogenase (ubiquinone) activity nuoA - 1.6.5.3 ko:K00330 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q4 k59_1116293_1 1158182.KB905020_gene2138 1.8e-27 107.0 COG3151@1|root,COG3151@2|Bacteria,1NAPI@1224|Proteobacteria,1SEY8@1236|Gammaproteobacteria,1WYT2@135613|Chromatiales 135613|Chromatiales S Protein of unknown function (DUF1249) - - - ko:K09920 - - - - ko00000 - - - DUF1249 k59_1231012_1 1122137.AQXF01000005_gene1264 3.55e-170 484.0 COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,2U211@28211|Alphaproteobacteria 28211|Alphaproteobacteria I Acyl-CoA dehydrogenase, C-terminal domain - - 1.3.8.4 ko:K00253 ko00280,ko01100,map00280,map01100 M00036 R04095 RC00246 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_1231012_2 1122137.AQXF01000005_gene1263 3.98e-67 211.0 COG3246@1|root,COG3246@2|Bacteria,1MZTP@1224|Proteobacteria,2TQKN@28211|Alphaproteobacteria 28211|Alphaproteobacteria S PFAM Prokaryotic protein of MA20_22960 - - - - - - - - - - - BKACE k59_214662_1 383372.Rcas_1888 3.2e-60 199.0 COG1960@1|root,COG1960@2|Bacteria,2G6E5@200795|Chloroflexi,3763W@32061|Chloroflexia 32061|Chloroflexia C PFAM acyl-CoA dehydrogenase domain protein - - 1.3.8.7 ko:K00249 ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320 M00013,M00036,M00087 R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754 RC00052,RC00068,RC00076,RC00095,RC00148,RC00246 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_725523_1 1195246.AGRI_12626 4.78e-101 315.0 COG0376@1|root,COG0376@2|Bacteria,1MUBF@1224|Proteobacteria,1RNA5@1236|Gammaproteobacteria,4641A@72275|Alteromonadaceae 1236|Gammaproteobacteria P Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity katG GO:0000302,GO:0003674,GO:0003824,GO:0004096,GO:0004601,GO:0005488,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009636,GO:0009987,GO:0010035,GO:0016209,GO:0016491,GO:0016684,GO:0016999,GO:0017001,GO:0017144,GO:0020037,GO:0033554,GO:0034599,GO:0034614,GO:0035690,GO:0042221,GO:0042493,GO:0042542,GO:0042737,GO:0042743,GO:0042744,GO:0044237,GO:0044248,GO:0044424,GO:0044444,GO:0044464,GO:0046677,GO:0046906,GO:0048037,GO:0050896,GO:0051186,GO:0051187,GO:0051716,GO:0055114,GO:0070301,GO:0070887,GO:0071236,GO:0072593,GO:0097159,GO:0097237,GO:0098754,GO:0098869,GO:1901363,GO:1901700,GO:1901701,GO:1990748 1.11.1.21 ko:K03782 ko00360,ko00380,ko00940,ko00983,ko01100,ko01110,map00360,map00380,map00940,map00983,map01100,map01110 - R00602,R00698,R02596,R02670,R03919,R04007,R07443,R11906 RC00034,RC00213,RC00767,RC02141 ko00000,ko00001,ko01000 - - - peroxidase k59_330418_1 1502852.FG94_04685 2.31e-16 80.9 COG0491@1|root,COG0491@2|Bacteria,1MURA@1224|Proteobacteria,2VJYK@28216|Betaproteobacteria,47387@75682|Oxalobacteraceae 28216|Betaproteobacteria P Metallo-beta-lactamase superfamily - - - - - - - - - - - - Lactamase_B,Rhodanese k59_549372_1 1285583.CCASEI_11275 1.76e-09 65.9 COG3021@1|root,COG3021@2|Bacteria,2I304@201174|Actinobacteria,22N9N@1653|Corynebacteriaceae 201174|Actinobacteria S Endonuclease/Exonuclease/phosphatase family - - - - - - - - - - - - Exo_endo_phos k59_1285383_2 1121935.AQXX01000141_gene2023 3.04e-107 325.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,1XIG8@135619|Oceanospirillales 135619|Oceanospirillales T Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains - - - ko:K02667 ko02020,map02020 M00501 - - ko00000,ko00001,ko00002,ko02022,ko02035 - - - HTH_8,Response_reg,Sigma54_activat k59_1070224_1 316407.85675804 3.57e-49 164.0 COG0437@1|root,COG0437@2|Bacteria,1MU1B@1224|Proteobacteria,1RPF5@1236|Gammaproteobacteria,3XNNR@561|Escherichia 1236|Gammaproteobacteria C Participates in the periplasmic electron-transferring activity of hydrogenase 2 during its catalytic turnover hybA GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0005975,GO:0006066,GO:0006071,GO:0006091,GO:0006113,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016052,GO:0019400,GO:0019405,GO:0019563,GO:0019588,GO:0019662,GO:0019751,GO:0031224,GO:0031226,GO:0042597,GO:0044237,GO:0044238,GO:0044248,GO:0044262,GO:0044275,GO:0044281,GO:0044282,GO:0044425,GO:0044459,GO:0044464,GO:0046164,GO:0046174,GO:0055114,GO:0071704,GO:0071944,GO:1901575,GO:1901615,GO:1901616 - - - - - - - - - - Fer4_11,Fer4_7 k59_1070224_2 316407.85675805 4.7e-104 308.0 COG1740@1|root,COG1740@2|Bacteria,1MWAC@1224|Proteobacteria,1RNTJ@1236|Gammaproteobacteria,3XMNB@561|Escherichia 1236|Gammaproteobacteria C This is one of three E.coli hydrogenases synthesized in response to different physiological conditions. HYD2 is involved in hydrogen uptake hybO GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006113,GO:0008150,GO:0008152,GO:0009055,GO:0009061,GO:0009897,GO:0009986,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0019897,GO:0019898,GO:0022900,GO:0031224,GO:0031226,GO:0031232,GO:0031233,GO:0031236,GO:0031237,GO:0032991,GO:0042597,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0044569,GO:0045333,GO:0048037,GO:0051536,GO:0051538,GO:0051539,GO:0051540,GO:0055114,GO:0071944,GO:0098552,GO:0098567,GO:1902494 1.12.5.1,1.12.99.6 ko:K05927,ko:K06282 ko00633,ko01120,map00633,map01120 - R08034 RC00250 ko00000,ko00001,ko01000 - - iAPECO1_1312.APECO1_76,iUTI89_1310.UTI89_C1040 NiFe_hyd_SSU_C,Oxidored_q6,TAT_signal k59_1581087_1 573065.Astex_3208 4.08e-107 326.0 COG3507@1|root,COG3507@2|Bacteria,1MWY2@1224|Proteobacteria,2UPFK@28211|Alphaproteobacteria,2KJY4@204458|Caulobacterales 204458|Caulobacterales M Belongs to the glycosyl hydrolase 43 family - - 3.2.1.37 ko:K01198 ko00520,ko01100,map00520,map01100 - R01433 RC00467 ko00000,ko00001,ko01000 - GH43 - Glyco_hydro_43 k59_1008736_1 1122622.ATWJ01000007_gene1684 2.27e-15 72.4 COG0691@1|root,COG0691@2|Bacteria,2GJX1@201174|Actinobacteria,4FEJ8@85021|Intrasporangiaceae 201174|Actinobacteria O the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA smpB GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - ko:K03664 - - - - ko00000 - - - SmpB k59_1008736_2 292563.Cyast_0492 5.78e-32 121.0 COG2928@1|root,COG2928@2|Bacteria,1G02Y@1117|Cyanobacteria 1117|Cyanobacteria S COGs COG2928 conserved - - - - - - - - - - - - DUF502 k59_1411230_2 436308.Nmar_1522 1.71e-19 85.9 arCOG08643@1|root,arCOG08643@2157|Archaea,41T5M@651137|Thaumarchaeota 651137|Thaumarchaeota S peptidyl-tyrosine sulfation - - - - - - - - - - - - - k59_1348519_1 998674.ATTE01000001_gene1872 4.85e-110 343.0 COG0189@1|root,COG0769@1|root,COG0189@2|Bacteria,COG0769@2|Bacteria,1MVN2@1224|Proteobacteria,1RS1C@1236|Gammaproteobacteria,46062@72273|Thiotrichales 72273|Thiotrichales HJM Carbamoyl-phosphate synthase L chain, ATP binding domain cphA - 6.3.2.29,6.3.2.30 ko:K03802 - - - - ko00000,ko01000 - - - CPSase_L_D2,Mur_ligase_C,Mur_ligase_M,RimK k59_842380_1 1122137.AQXF01000004_gene1849 4.16e-206 574.0 COG0821@1|root,COG0821@2|Bacteria,1MUAX@1224|Proteobacteria,2TQSI@28211|Alphaproteobacteria 28211|Alphaproteobacteria I Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate ispG GO:0003674,GO:0003824,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016491,GO:0016725,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046429,GO:0046490,GO:0052592,GO:0055114,GO:0071704,GO:0090407,GO:1901135,GO:1901576 1.17.7.1,1.17.7.3 ko:K03526 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R08689,R10859 RC01486 ko00000,ko00001,ko00002,ko01000 - - - GcpE k59_279589_1 316407.85676168 9.35e-142 404.0 COG3058@1|root,COG3058@2|Bacteria,1NK06@1224|Proteobacteria,1RQC4@1236|Gammaproteobacteria,3XMIZ@561|Escherichia 1236|Gammaproteobacteria O Necessary for formate dehydrogenase activity fdhE GO:0003674,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006091,GO:0006807,GO:0008150,GO:0008152,GO:0008199,GO:0009061,GO:0009987,GO:0010467,GO:0015980,GO:0019538,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0046872,GO:0046914,GO:0051604,GO:0055114,GO:0071704,GO:1901564 - ko:K02380 - - - - ko00000 - - - FdhE k59_1348527_2 882.DVU_1294 8.31e-10 61.6 COG1451@1|root,COG1451@2|Bacteria,1MXZU@1224|Proteobacteria,42QYE@68525|delta/epsilon subdivisions,2X5HW@28221|Deltaproteobacteria,2MGRC@213115|Desulfovibrionales 28221|Deltaproteobacteria S WLM domain - - - ko:K07043 - - - - ko00000 - - - DUF45 k59_619574_1 1510531.JQJJ01000012_gene1727 3.44e-78 259.0 COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,2TS2I@28211|Alphaproteobacteria,3JSVM@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria F Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen nrdJ - 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - Ribonuc_red_2_N,Ribonuc_red_lgC k59_1292573_1 1415778.JQMM01000001_gene1256 2.84e-51 181.0 COG1629@1|root,COG4771@2|Bacteria,1MW7D@1224|Proteobacteria,1RNET@1236|Gammaproteobacteria,1J8HY@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Outer membrane protein beta-barrel family - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_221534_1 980584.AFPB01000163_gene2285 1.93e-80 243.0 COG2003@1|root,COG2003@2|Bacteria,4NP8R@976|Bacteroidetes,1I2NK@117743|Flavobacteriia 976|Bacteroidetes L RadC-like JAB domain - - - - - - - - - - - - RadC k59_1462252_1 697282.Mettu_4406 6.8e-77 245.0 COG2801@1|root,COG2801@2|Bacteria,1MWVQ@1224|Proteobacteria,1RN12@1236|Gammaproteobacteria 1236|Gammaproteobacteria L PFAM Integrase catalytic - - - - - - - - - - - - HTH_23,HTH_28,HTH_32,rve k59_1008759_1 330214.NIDE0168 4.11e-89 273.0 COG0112@1|root,COG0112@2|Bacteria,3J0CB@40117|Nitrospirae 40117|Nitrospirae E Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism glyA - 2.1.2.1 ko:K00600 ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523 M00140,M00141,M00346,M00532 R00945,R09099 RC00022,RC00112,RC01583,RC02958 ko00000,ko00001,ko00002,ko01000 - - - SHMT k59_556363_1 1265503.KB905180_gene3835 1.5e-110 331.0 COG0126@1|root,COG0126@2|Bacteria,1MUNU@1224|Proteobacteria,1RMUQ@1236|Gammaproteobacteria,2Q6EA@267889|Colwelliaceae 1236|Gammaproteobacteria F Belongs to the phosphoglycerate kinase family pgk GO:0003674,GO:0003824,GO:0004618,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016052,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576 2.7.2.3 ko:K00927 ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01512 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000,ko04147 - - iSbBS512_1146.SbBS512_E3351 PGK k59_619592_1 323097.Nham_3524 1.15e-73 235.0 COG2239@1|root,COG2239@2|Bacteria,1MW24@1224|Proteobacteria,2TRWK@28211|Alphaproteobacteria,3JSGK@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria P Acts as a magnesium transporter mgtE GO:0000287,GO:0003674,GO:0005488,GO:0005515,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0015693,GO:0030001,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0046872,GO:0046983,GO:0051179,GO:0051234,GO:0070838,GO:0072511 - ko:K06213 - - - - ko00000,ko02000 1.A.26.1 - - CBS,MgtE,MgtE_N k59_842413_1 1415778.JQMM01000001_gene761 1.79e-79 245.0 COG0668@1|root,COG0668@2|Bacteria,1N596@1224|Proteobacteria,1RQZP@1236|Gammaproteobacteria,1JC09@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M COG0668 Small-conductance mechanosensitive channel mscS GO:0003674,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006884,GO:0008150,GO:0008361,GO:0008381,GO:0009987,GO:0009992,GO:0015267,GO:0016020,GO:0016021,GO:0016043,GO:0019725,GO:0022607,GO:0022803,GO:0022836,GO:0022857,GO:0030104,GO:0031224,GO:0031226,GO:0032535,GO:0034220,GO:0042592,GO:0042802,GO:0043933,GO:0044085,GO:0044425,GO:0044459,GO:0044464,GO:0048878,GO:0051179,GO:0051234,GO:0051259,GO:0051260,GO:0055082,GO:0055085,GO:0065003,GO:0065007,GO:0065008,GO:0071840,GO:0071944,GO:0090066 - ko:K03442 - - - - ko00000,ko02000 1.A.23.2 - - MS_channel,TM_helix k59_500419_1 713586.KB900536_gene2124 7.87e-90 271.0 COG0224@1|root,COG0224@2|Bacteria,1MU28@1224|Proteobacteria,1RNWJ@1236|Gammaproteobacteria,1WW4K@135613|Chromatiales 135613|Chromatiales C Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex atpG - - ko:K02115 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt k59_1411286_1 1121943.KB899990_gene3693 5.91e-88 272.0 COG1004@1|root,COG1004@2|Bacteria,1MW5U@1224|Proteobacteria,1RMVW@1236|Gammaproteobacteria,1XI8P@135619|Oceanospirillales 135619|Oceanospirillales M Belongs to the UDP-glucose GDP-mannose dehydrogenase family - - 1.1.1.22 ko:K00012 ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100 M00014,M00129,M00361,M00362 R00286 RC00291 ko00000,ko00001,ko00002,ko01000 - - - UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N k59_1462269_1 1403313.AXBR01000023_gene2481 2.25e-52 180.0 COG1071@1|root,COG1071@2|Bacteria,1TQDG@1239|Firmicutes,4H9PR@91061|Bacilli,1ZARF@1386|Bacillus 91061|Bacilli C Dehydrogenase E1 component pdhA2 - 1.2.4.1 ko:K00161 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230 M00307 R00014,R00209,R01699,R03270 RC00004,RC00027,RC00627,RC02742,RC02744,RC02882 br01601,ko00000,ko00001,ko00002,ko01000 - - - E1_dh k59_1348563_1 1144305.PMI02_01773 1.28e-96 296.0 COG0033@1|root,COG0033@2|Bacteria,1MU5S@1224|Proteobacteria,2TRUJ@28211|Alphaproteobacteria,2K2CM@204457|Sphingomonadales 204457|Sphingomonadales G Phosphoglucomutase pgm - 5.4.2.2 ko:K01835 ko00010,ko00030,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130 M00549 R00959,R01057,R08639 RC00408 ko00000,ko00001,ko00002,ko01000 - - - PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV k59_619609_2 297246.lpp0861 1.83e-32 126.0 COG0379@1|root,COG0379@2|Bacteria,1MWQU@1224|Proteobacteria,1RMFS@1236|Gammaproteobacteria,1JCWZ@118969|Legionellales 118969|Legionellales H Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate nadA - 2.5.1.72 ko:K03517 ko00760,ko01100,map00760,map01100 M00115 R04292 RC01119 ko00000,ko00001,ko00002,ko01000 - - - NadA k59_1123192_1 1056820.KB900700_gene1077 5.96e-62 196.0 COG1136@1|root,COG1136@2|Bacteria,1NHCD@1224|Proteobacteria,1RNIX@1236|Gammaproteobacteria,2PN27@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria V ABC transporter - - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_1123192_2 880071.Fleli_3838 8.4e-09 55.5 COG0577@1|root,COG0577@2|Bacteria,4NFUG@976|Bacteroidetes,47NZD@768503|Cytophagia 976|Bacteroidetes V MacB-like periplasmic core domain - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_54026_1 395494.Galf_0425 3.4e-105 315.0 COG0014@1|root,COG0014@2|Bacteria,1MUGJ@1224|Proteobacteria,2VJ5M@28216|Betaproteobacteria,44V7E@713636|Nitrosomonadales 28216|Betaproteobacteria E Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate proA GO:0003674,GO:0003824,GO:0004350,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016491,GO:0016620,GO:0016903,GO:0018130,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.2.1.41 ko:K00147 ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230 M00015 R03313 RC00684 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_54027_1 1144305.PMI02_02892 2.06e-112 329.0 COG1028@1|root,COG1028@2|Bacteria,1MU3W@1224|Proteobacteria,2TT5X@28211|Alphaproteobacteria,2K05I@204457|Sphingomonadales 204457|Sphingomonadales IQ Short-chain dehydrogenase reductase sdr - - - - - - - - - - - - adh_short_C2 k59_1746121_1 1192759.AKIB01000026_gene2139 9.36e-66 214.0 COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2TQR1@28211|Alphaproteobacteria,2K1ZD@204457|Sphingomonadales 204457|Sphingomonadales C belongs to the aldehyde dehydrogenase family - - - - - - - - - - - - Aldedh k59_1348576_1 314278.NB231_08315 1.36e-78 243.0 COG3344@1|root,COG3344@2|Bacteria,1MVI1@1224|Proteobacteria,1RQP7@1236|Gammaproteobacteria 1236|Gammaproteobacteria L reverse transcriptase - - - - - - - - - - - - GIIM,RVT_1 k59_732680_1 314345.SPV1_00165 4.7e-12 73.9 COG0760@1|root,COG0760@2|Bacteria,1MWV0@1224|Proteobacteria 1224|Proteobacteria O Peptidylprolyl isomerase ppiD - 5.2.1.8 ko:K01802,ko:K03770 - - - - ko00000,ko01000,ko03110 - - - Rotamase_2,SurA_N_3 k59_1292595_1 1556290.A0A0A0RM00_9CAUD 6.28e-57 196.0 4QAXQ@10239|Viruses,4QRFY@28883|Caudovirales,4QM52@10699|Siphoviridae 10699|Siphoviridae S ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor - - - - - - - - - - - - - k59_1798539_1 1122137.AQXF01000006_gene956 3.35e-145 420.0 COG0201@1|root,COG0201@2|Bacteria,1MVU7@1224|Proteobacteria,2TQMT@28211|Alphaproteobacteria 28211|Alphaproteobacteria U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently secY - - ko:K03076 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5 - - SecY k59_279640_2 436308.Nmar_0008 1.7e-139 406.0 COG1252@1|root,arCOG01067@2157|Archaea 2157|Archaea C COG1252 NADH dehydrogenase, FAD-containing subunit ndh2 - 1.6.99.3 ko:K03885 ko00190,map00190 - - - ko00000,ko00001,ko01000 - - - Pyr_redox_2 k59_842439_1 31870.EFQ36803 9.24e-13 75.5 COG0654@1|root,KOG3855@2759|Eukaryota,39YI5@33154|Opisthokonta,3NW47@4751|Fungi,3QNA1@4890|Ascomycota,217H7@147550|Sordariomycetes,1F4RS@1028384|Glomerellales 4751|Fungi CH FAD binding domain-containing protein - - - ko:K15387 - - - - ko00000,ko01008 - - - FAD_binding_3 k59_1008781_1 2340.JV46_13040 2.76e-89 275.0 COG0674@1|root,COG0674@2|Bacteria,1NBSJ@1224|Proteobacteria,1S0WV@1236|Gammaproteobacteria,1J85H@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg korA - 1.2.7.11,1.2.7.3 ko:K00174 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - PFOR_II,POR,POR_N,Transketolase_C k59_1633941_2 1120934.KB894458_gene1459 1.09e-12 65.5 COG3064@1|root,COG3064@2|Bacteria,2GQVM@201174|Actinobacteria 201174|Actinobacteria M Excalibur domain protein - - - - - - - - - - - - Excalibur,PASTA k59_1123244_1 1150864.MILUP08_42807 2.14e-41 152.0 COG3369@1|root,COG3369@2|Bacteria,2GK8Q@201174|Actinobacteria,4DMGK@85008|Micromonosporales 201174|Actinobacteria S Ferritin-like - - - - - - - - - - - - Ferritin-like,zf-CDGSH k59_1070322_1 1382306.JNIM01000001_gene4069 6.86e-49 173.0 COG0074@1|root,COG0074@2|Bacteria,2G7NQ@200795|Chloroflexi 200795|Chloroflexi C CoA-ligase - - - ko:K02381 - - - - ko00000 - - - CoA_binding,Ligase_CoA k59_1523661_1 795359.TOPB45_0109 7.34e-61 209.0 COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,2GHH0@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria G Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate - - 2.7.9.2 ko:K01007 ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200 M00173,M00374 R00199 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - PEP-utilizers,PEP-utilizers_C,PPDK_N k59_279673_2 1210045.ALNP01000027_gene816 1.89e-32 116.0 COG0713@1|root,COG0713@2|Bacteria,2IHNW@201174|Actinobacteria 201174|Actinobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoK2 GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0008137,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0030964,GO:0032991,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0050136,GO:0055114,GO:0070469,GO:0070470,GO:0071944,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1990204 1.6.5.3 ko:K00340 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q2 k59_671510_1 1433126.BN938_0646 7.01e-26 108.0 COG3547@1|root,COG3547@2|Bacteria,4NHYP@976|Bacteroidetes,2FKYS@200643|Bacteroidia,22VBA@171550|Rikenellaceae 976|Bacteroidetes L Transposase - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_842502_1 1216007.AOPM01000014_gene135 1.05e-93 285.0 COG1215@1|root,COG1215@2|Bacteria,1MWH9@1224|Proteobacteria,1RPTN@1236|Gammaproteobacteria,2Q11F@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria M COG0463 Glycosyltransferases involved in cell wall biogenesis - - 2.4.1.266 ko:K13693 - - - - ko00000,ko01000,ko01003 - GT81 - - k59_445359_2 330214.NIDE0257 2.11e-70 217.0 COG3215@1|root,COG3215@2|Bacteria 2|Bacteria NU PilZ domain - - - ko:K02676 - - - - ko00000,ko02035,ko02044 - - - PilZ,Response_reg k59_1348602_1 7029.ACYPI37822-PA 9.91e-07 52.8 2EA4H@1|root,2SZ18@2759|Eukaryota,38VIS@33154|Opisthokonta,3C5X1@33208|Metazoa,3DR66@33213|Bilateria,428IV@6656|Arthropoda,3SSBM@50557|Insecta 7029.ACYPI37822-PA|- - - - - - - - - - - - - - - - k59_1348602_4 136037.KDR02726 8.31e-26 97.8 2DZEY@1|root,2S6ZB@2759|Eukaryota,3A8VS@33154|Opisthokonta,3BUFV@33208|Metazoa,3DB2P@33213|Bilateria,421U6@6656|Arthropoda 33208|Metazoa - - - - - - - - - - - - - - - k59_783984_1 1168034.FH5T_20550 1.85e-133 391.0 COG2223@1|root,COG2223@2|Bacteria,4NHX9@976|Bacteroidetes,2FZ04@200643|Bacteroidia 976|Bacteroidetes P Major Facilitator Superfamily - - - ko:K08177 - - - - ko00000,ko02000 2.A.1.11 - - MFS_1 k59_1071460_1 1122137.AQXF01000002_gene360 1.81e-144 440.0 COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,2TS2I@28211|Alphaproteobacteria 28211|Alphaproteobacteria F Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen nrdJ - 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - Ribonuc_red_2_N,Ribonuc_red_lgC k59_55271_1 869210.Marky_2117 4.92e-11 61.6 COG2128@1|root,COG2128@2|Bacteria,1WMUS@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus C Carboxymuconolactone decarboxylase family - - - - - - - - - - - - CMD k59_55271_2 477228.YO5_09400 4.81e-30 110.0 COG3565@1|root,COG3565@2|Bacteria,1RD7C@1224|Proteobacteria,1S6SD@1236|Gammaproteobacteria,1Z285@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria S dioxygenase of extradiol dioxygenase family - - - ko:K06991 - - - - ko00000 - - - Glyoxalase k59_165582_2 118797.XP_007454900.1 1.14e-29 113.0 COG0491@1|root,KOG0813@2759|Eukaryota,38RE4@33154|Opisthokonta,3BIVM@33208|Metazoa,3CRVK@33213|Bilateria,487MR@7711|Chordata,48W2A@7742|Vertebrata,3JDMU@40674|Mammalia,4J99U@91561|Cetartiodactyla 33208|Metazoa S Hydroxyacylglutathione hydrolase - - 3.1.2.6 ko:K01069 ko00620,map00620 - R01736 RC00004,RC00137 ko00000,ko00001,ko01000 - - - HAGH_C,Lactamase_B k59_111245_2 366394.Smed_5501 4.09e-07 49.7 2E7PS@1|root,3325B@2|Bacteria,1N7R7@1224|Proteobacteria,2UFCM@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Evidence 4 Homologs of previously reported genes of - - - - - - - - - - - - - k59_1635027_1 1415778.JQMM01000001_gene855 2.08e-38 145.0 COG3107@1|root,COG3107@2|Bacteria,1MUHR@1224|Proteobacteria,1RXX4@1236|Gammaproteobacteria,1J4Z4@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M lipoprotein lpoA GO:0000270,GO:0003674,GO:0005575,GO:0005623,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009279,GO:0009987,GO:0016020,GO:0019867,GO:0030203,GO:0030234,GO:0030312,GO:0030313,GO:0031241,GO:0031975,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044425,GO:0044462,GO:0044464,GO:0050790,GO:0065007,GO:0065009,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:0098552,GO:0098772,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 - ko:K07121 - - - - ko00000 - - - LppC k59_843618_1 1278078.G419_05882 1.79e-05 47.4 COG0497@1|root,COG0497@2|Bacteria,2GIVG@201174|Actinobacteria,4FVAD@85025|Nocardiaceae 201174|Actinobacteria L May be involved in recombinational repair of damaged DNA recN GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944 - ko:K03631 - - - - ko00000,ko03400 - - - AAA_23,SMC_N k59_843618_2 1121877.JQKF01000002_gene1735 1.47e-123 369.0 COG0504@1|root,COG0504@2|Bacteria,2GJ13@201174|Actinobacteria,4CMQD@84992|Acidimicrobiia 84992|Acidimicrobiia F Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates pyrG - 6.3.4.2 ko:K01937 ko00240,ko01100,map00240,map01100 M00052 R00571,R00573 RC00010,RC00074 ko00000,ko00001,ko00002,ko01000 - - - CTP_synth_N,GATase k59_620872_1 983920.Y88_0535 5.4e-38 128.0 COG0636@1|root,COG0636@2|Bacteria,1NAIE@1224|Proteobacteria,2UBRD@28211|Alphaproteobacteria,2K7IN@204457|Sphingomonadales 204457|Sphingomonadales C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation - - - ko:K02110 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt_C k59_620872_2 342113.DM82_6241 2.8e-43 147.0 COG0356@1|root,COG0356@2|Bacteria,1RBEV@1224|Proteobacteria,2WGC1@28216|Betaproteobacteria,1KG2U@119060|Burkholderiaceae 28216|Betaproteobacteria C it plays a direct role in the translocation of protons across the membrane - - - ko:K02108 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko03110 3.A.2.1 - - ATP-synt_A k59_1124388_1 913325.N799_03765 1.33e-88 274.0 COG0196@1|root,COG0196@2|Bacteria,1MV9I@1224|Proteobacteria,1RN44@1236|Gammaproteobacteria,1X3EA@135614|Xanthomonadales 135614|Xanthomonadales H Belongs to the ribF family ribF - 2.7.1.26,2.7.7.2 ko:K11753 ko00740,ko01100,ko01110,map00740,map01100,map01110 M00125 R00161,R00549 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - FAD_syn,Flavokinase k59_1124388_2 754477.Q7C_467 7.72e-14 68.9 COG0597@1|root,COG0597@2|Bacteria,1RGV9@1224|Proteobacteria,1S60E@1236|Gammaproteobacteria,460TI@72273|Thiotrichales 72273|Thiotrichales MU This protein specifically catalyzes the removal of signal peptides from prolipoproteins lspA - 3.4.23.36 ko:K03101 ko03060,map03060 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_A8 k59_1009988_1 1249627.D779_0297 3.42e-31 122.0 COG0733@1|root,COG0733@2|Bacteria,1MUZJ@1224|Proteobacteria,1RPCT@1236|Gammaproteobacteria,1WWZ8@135613|Chromatiales 135613|Chromatiales S Belongs to the sodium neurotransmitter symporter (SNF) (TC 2.A.22) family - - - ko:K03308 - - - - ko00000 2.A.22.4,2.A.22.5 - - SNF k59_1009988_2 2342.SOPEG_3249 4.06e-31 114.0 COG2867@1|root,COG2867@2|Bacteria,1RGUH@1224|Proteobacteria,1S61C@1236|Gammaproteobacteria 1236|Gammaproteobacteria I oligoketide cyclase lipid transport protein ratA GO:0003674,GO:0005488,GO:0006417,GO:0006446,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0017148,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0034248,GO:0034249,GO:0043021,GO:0043023,GO:0044877,GO:0045947,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0080090,GO:2000112,GO:2000113 - - - - - - - - - - Polyketide_cyc k59_1071471_1 765913.ThidrDRAFT_2097 5.9e-09 55.5 COG0041@1|root,COG0041@2|Bacteria,1RCWJ@1224|Proteobacteria,1S3VN@1236|Gammaproteobacteria,1WY0E@135613|Chromatiales 135613|Chromatiales F Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) purE - 5.4.99.18 ko:K01588 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R07405 RC01947 ko00000,ko00001,ko00002,ko01000 - - - AIRC k59_280855_1 1123228.AUIH01000011_gene2055 1.6e-70 217.0 COG1327@1|root,COG1327@2|Bacteria,1RE7V@1224|Proteobacteria,1S3P9@1236|Gammaproteobacteria,1XJKR@135619|Oceanospirillales 135619|Oceanospirillales K Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes nrdR - - ko:K07738 - - - - ko00000,ko03000 - - - ATP-cone k59_1799695_1 398767.Glov_0702 3.07e-28 116.0 COG1207@1|root,COG1207@2|Bacteria,1MUPH@1224|Proteobacteria,42N3K@68525|delta/epsilon subdivisions,2WIMV@28221|Deltaproteobacteria 28221|Deltaproteobacteria M Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain glmU - 2.3.1.157,2.7.7.23 ko:K04042,ko:K11528 ko00520,ko01100,ko01130,map00520,map01100,map01130 M00362 R00416,R05332 RC00002,RC00004,RC00166 ko00000,ko00001,ko00002,ko01000 - - - Hexapep,NTP_transf_3,NTP_transferase k59_501557_1 1121479.AUBS01000004_gene2411 1.88e-15 74.7 COG1188@1|root,COG1188@2|Bacteria,1MZR6@1224|Proteobacteria,2UBS3@28211|Alphaproteobacteria 28211|Alphaproteobacteria J Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit (S4 paralog) hslR - - ko:K04762 - - - - ko00000,ko03110 - - - S4 k59_1183157_1 318161.Sden_2171 2.85e-104 321.0 COG0793@1|root,COG0793@2|Bacteria,1R5B7@1224|Proteobacteria,1RYAU@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Peptidase family S41 - - - - - - - - - - - - Peptidase_S41 k59_1071475_1 324602.Caur_1750 5.37e-67 226.0 COG0209@1|root,COG0209@2|Bacteria,2G5PW@200795|Chloroflexi,37772@32061|Chloroflexia 32061|Chloroflexia F Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen - - 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - Ribonuc_red_lgC,Ribonuc_red_lgN k59_165596_1 1208321.D104_01750 5.69e-47 165.0 COG0715@1|root,COG0715@2|Bacteria,1MWDN@1224|Proteobacteria,1RPUP@1236|Gammaproteobacteria,1XI5S@135619|Oceanospirillales 135619|Oceanospirillales P COG0715 ABC-type nitrate sulfonate bicarbonate transport systems, periplasmic components nasS - - ko:K22067 - - - - ko00000,ko02022 - - - NMT1_2 k59_1524823_1 1187851.A33M_2618 1.18e-52 174.0 COG0247@1|root,COG0247@2|Bacteria,1MWTK@1224|Proteobacteria,2TR9H@28211|Alphaproteobacteria 28211|Alphaproteobacteria C glycolate oxidase iron-sulfur subunit - - - ko:K18928 - - - - ko00000 - - - CCG k59_1524823_2 1123354.AUDR01000001_gene2031 5.34e-12 65.1 COG1414@1|root,COG1414@2|Bacteria,1MUNW@1224|Proteobacteria,2VHB6@28216|Betaproteobacteria,1KRM2@119069|Hydrogenophilales 119069|Hydrogenophilales K helix_turn_helix isocitrate lyase regulation - - - - - - - - - - - - HTH_IclR,IclR k59_903826_1 1223545.GS4_03_00370 1.83e-07 57.0 COG1615@1|root,COG1615@2|Bacteria,2GMP3@201174|Actinobacteria,4GAJR@85026|Gordoniaceae 201174|Actinobacteria S Uncharacterised protein family (UPF0182) - GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 - ko:K09118 - - - - ko00000 - - - UPF0182 k59_1071484_1 1163407.UU7_05698 1.73e-10 65.9 COG1228@1|root,COG1228@2|Bacteria,1R6NP@1224|Proteobacteria,1SZBD@1236|Gammaproteobacteria,1X5QW@135614|Xanthomonadales 135614|Xanthomonadales Q Amidohydrolase family - - - - - - - - - - - - Amidohydro_1 k59_1529627_2 436308.Nmar_1709 1.3e-107 327.0 COG0661@1|root,arCOG01189@2157|Archaea,41SYQ@651137|Thaumarchaeota 651137|Thaumarchaeota S ABC1 family - - - - - - - - - - - - ABC1 k59_1642706_1 1123261.AXDW01000002_gene1657 4.84e-54 181.0 COG2041@1|root,COG2041@2|Bacteria,1MUW0@1224|Proteobacteria,1RQ2J@1236|Gammaproteobacteria,1X3VH@135614|Xanthomonadales 135614|Xanthomonadales C Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide msrP - - ko:K07147 - - - - ko00000,ko01000 - - - Oxidored_molyb k59_1077531_1 935863.AWZR01000006_gene1298 6.79e-49 171.0 COG0534@1|root,COG0534@2|Bacteria,1MV6B@1224|Proteobacteria,1RPGF@1236|Gammaproteobacteria,1X65W@135614|Xanthomonadales 135614|Xanthomonadales V MatE - - - ko:K03327 - - - - ko00000,ko02000 2.A.66.1 - - MatE k59_1529628_1 1198452.Jab_2c09360 2.52e-25 110.0 COG0642@1|root,COG5002@1|root,COG0642@2|Bacteria,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria 1224|Proteobacteria T Histidine kinase - - - - - - - - - - - - HATPase_c,HisKA,Hpt,Response_reg k59_625636_1 318996.AXAZ01000013_gene2986 7.22e-12 72.0 COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TR1S@28211|Alphaproteobacteria,3JXE3@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria T Single cache domain 3 - - 2.7.13.3 ko:K02482 - - - - ko00000,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,HisKA,sCache_3_3 k59_1134183_1 311402.Avi_0973 2.12e-42 152.0 COG4148@1|root,COG4148@2|Bacteria,1MU8K@1224|Proteobacteria,2TR1Z@28211|Alphaproteobacteria,4B8X9@82115|Rhizobiaceae 28211|Alphaproteobacteria P Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system modC - 3.6.3.29 ko:K02017 ko02010,map02010 M00189 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.8 - - ABC_tran,TOBE k59_1247203_1 1522072.IL54_2253 6.83e-59 192.0 COG1960@1|root,COG1960@2|Bacteria,1REWC@1224|Proteobacteria,2U8I5@28211|Alphaproteobacteria,2K2J2@204457|Sphingomonadales 204457|Sphingomonadales I Acyl-CoA dehydrogenase, C-terminal domain - - - - - - - - - - - - Acyl-CoA_dh_1 k59_1021592_1 1121403.AUCV01000002_gene648 2.39e-73 234.0 COG0763@1|root,COG0763@2|Bacteria,1MVBI@1224|Proteobacteria,42P35@68525|delta/epsilon subdivisions,2WJFA@28221|Deltaproteobacteria,2MIFD@213118|Desulfobacterales 28221|Deltaproteobacteria M Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell lpxB GO:0003674,GO:0005488,GO:0005543,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008289,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0019637,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0046467,GO:0046493,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 2.4.1.182 ko:K00748 ko00540,ko01100,map00540,map01100 M00060 R04606 RC00005,RC00059 ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT19 - LpxB k59_512603_1 1158150.KB906241_gene712 3.72e-19 87.0 COG0367@1|root,COG0367@2|Bacteria,1PRFK@1224|Proteobacteria,1RNBE@1236|Gammaproteobacteria,1WW7I@135613|Chromatiales 135613|Chromatiales E Asparagine synthase - - 6.3.5.4 ko:K01953 ko00250,ko01100,ko01110,map00250,map01100,map01110 - R00578 RC00010 ko00000,ko00001,ko01000,ko01002 - - - Asn_synthase,GATase_7 k59_456255_2 1214242.B446_01305 7.04e-27 110.0 COG2220@1|root,COG2220@2|Bacteria,2GMFQ@201174|Actinobacteria 201174|Actinobacteria S Zn-dependent hydrolases of the beta-lactamase fold - - - - - - - - - - - - Lactamase_B,Lactamase_B_2 k59_1360183_1 1123279.ATUS01000001_gene2121 1.82e-85 263.0 COG0108@1|root,COG0108@2|Bacteria,1MU8P@1224|Proteobacteria,1RQ49@1236|Gammaproteobacteria,1J4CF@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate ribB - 3.5.4.25,4.1.99.12 ko:K14652 ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110 M00125,M00840 R00425,R07281 RC00293,RC01792,RC01815,RC02504 ko00000,ko00001,ko00002,ko01000 - - - DHBP_synthase,GTP_cyclohydro2 k59_343585_1 762376.AXYL_02275 2.76e-182 513.0 COG0016@1|root,COG0016@2|Bacteria,1MVD7@1224|Proteobacteria,2VIM9@28216|Betaproteobacteria,3T1N5@506|Alcaligenaceae 28216|Betaproteobacteria J Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily pheS - 6.1.1.20 ko:K01889 ko00970,map00970 M00359,M00360 R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Phe_tRNA-synt_N,tRNA-synt_2d k59_1360184_1 1232410.KI421417_gene2752 5.79e-33 127.0 COG0380@1|root,COG0380@2|Bacteria,1MUIY@1224|Proteobacteria,42NBU@68525|delta/epsilon subdivisions,2WJX9@28221|Deltaproteobacteria,43S30@69541|Desulfuromonadales 28221|Deltaproteobacteria G Glycosyltransferase family 20 otsAB - 2.4.1.15,2.4.1.347,3.1.3.12 ko:K00697,ko:K16055 ko00500,ko01100,map00500,map01100 - R02737,R02778 RC00005,RC00017,RC00049,RC02748 ko00000,ko00001,ko01000,ko01003 - GT20 - Glyco_transf_20,S6PP,Trehalose_PPase k59_1360184_2 251221.35214443 2e-13 69.7 COG0668@1|root,COG0668@2|Bacteria,1G08V@1117|Cyanobacteria 1117|Cyanobacteria M mechanosensitive ion channel mscS - - - - - - - - - - - MS_channel k59_1699114_1 1122611.KB904007_gene7840 4.95e-06 56.6 COG2114@1|root,COG3899@1|root,COG2114@2|Bacteria,COG3899@2|Bacteria,2I2U4@201174|Actinobacteria,4EN2T@85012|Streptosporangiales 201174|Actinobacteria T AAA ATPase domain - - - - - - - - - - - - AAA_16,BTAD,Guanylate_cyc,Trans_reg_C k59_343586_1 1280948.HY36_07075 7.46e-43 152.0 COG0583@1|root,COG0583@2|Bacteria,1MW16@1224|Proteobacteria,2TRIG@28211|Alphaproteobacteria,440NZ@69657|Hyphomonadaceae 28211|Alphaproteobacteria K Bacterial regulatory helix-turn-helix protein, lysR family - - - - - - - - - - - - HTH_1,LysR_substrate k59_1642730_2 1131266.ARWQ01000001_gene1379 1.9e-38 135.0 COG0071@1|root,arCOG01833@2157|Archaea,41SPJ@651137|Thaumarchaeota 651137|Thaumarchaeota O Belongs to the small heat shock protein (HSP20) family - - - ko:K13993 ko04141,map04141 - - - ko00000,ko00001,ko03110 - - - HSP20 k59_739135_1 1144307.PMI04_04565 2.77e-42 146.0 COG1414@1|root,COG1414@2|Bacteria,1RA2W@1224|Proteobacteria,2U0RW@28211|Alphaproteobacteria,2K3WV@204457|Sphingomonadales 204457|Sphingomonadales K Bacterial transcriptional regulator - - - - - - - - - - - - HTH_IclR,IclR k59_117571_1 314285.KT71_10027 2.99e-22 90.9 2E4XG@1|root,32ZRD@2|Bacteria,1N79W@1224|Proteobacteria,1TAUP@1236|Gammaproteobacteria,1JBF4@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S tryptophan synthase subunit beta - - - - - - - - - - - - - k59_117571_2 1209072.ALBT01000004_gene678 3.02e-18 93.2 COG2931@1|root,COG4254@1|root,COG4932@1|root,COG2931@2|Bacteria,COG4254@2|Bacteria,COG4932@2|Bacteria,1MU7T@1224|Proteobacteria,1RNK8@1236|Gammaproteobacteria,1FGNW@10|Cellvibrio 1236|Gammaproteobacteria MQ Cadherin-like - - - - - - - - - - - - Cadherin,Cadherin_3,HemolysinCabind,PA14 k59_287086_1 1122611.KB903952_gene5821 6.46e-189 543.0 COG2072@1|root,COG2072@2|Bacteria,2GKYU@201174|Actinobacteria,4EMHG@85012|Streptosporangiales 201174|Actinobacteria P Flavin-binding monooxygenase-like pamO GO:0003674,GO:0003824,GO:0004497,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016491,GO:0016705,GO:0016709,GO:0016999,GO:0017000,GO:0017144,GO:0018130,GO:0044237,GO:0044249,GO:0046483,GO:0055114,GO:0071704,GO:1901334,GO:1901336,GO:1901360,GO:1901362,GO:1901576 1.14.13.170,1.14.13.171,1.14.13.22 ko:K03379,ko:K18091 ko00930,ko01120,ko01130,ko01220,map00930,map01120,map01130,map01220 M00819 R02231,R06622 RC00662,RC01550 ko00000,ko00001,ko00002,ko01000 - - - FMO-like,NAD_binding_8,Pyr_redox_2,Pyr_redox_3 k59_1077559_1 395961.Cyan7425_1541 1.51e-83 256.0 COG0031@1|root,COG0031@2|Bacteria,1G1AB@1117|Cyanobacteria,3KGMS@43988|Cyanothece 1117|Cyanobacteria H Belongs to the cysteine synthase cystathionine beta- synthase family cysK - 2.5.1.47 ko:K01738 ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230 M00021 R00897,R03601,R04859 RC00020,RC02814,RC02821 ko00000,ko00001,ko00002,ko01000 - - - PALP k59_1699131_1 1209072.ALBT01000032_gene1979 9.08e-76 238.0 COG0112@1|root,COG0112@2|Bacteria,1MUIS@1224|Proteobacteria,1RMHQ@1236|Gammaproteobacteria,1FGNZ@10|Cellvibrio 1236|Gammaproteobacteria E Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism glyA GO:0001505,GO:0003674,GO:0003824,GO:0004372,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006544,GO:0006545,GO:0006546,GO:0006563,GO:0006565,GO:0006730,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008270,GO:0008652,GO:0009056,GO:0009058,GO:0009063,GO:0009069,GO:0009070,GO:0009071,GO:0009987,GO:0016053,GO:0016054,GO:0016740,GO:0016741,GO:0016742,GO:0017144,GO:0019264,GO:0019752,GO:0019842,GO:0030170,GO:0036094,GO:0042133,GO:0042135,GO:0042136,GO:0042737,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046395,GO:0046872,GO:0046914,GO:0048037,GO:0050662,GO:0065007,GO:0065008,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1901607 2.1.2.1 ko:K00600 ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523 M00140,M00141,M00346,M00532 R00945,R09099 RC00022,RC00112,RC01583,RC02958 ko00000,ko00001,ko00002,ko01000 - - iG2583_1286.G2583_3081 SHMT k59_61149_1 745718.JADT01000001_gene1575 8.83e-110 338.0 COG4232@1|root,COG4232@2|Bacteria,4NEW6@976|Bacteroidetes,1HX34@117743|Flavobacteriia 976|Bacteroidetes CO Thiol disulfide interchange protein dsbD - 1.8.1.8 ko:K04084 - - - - ko00000,ko01000,ko03110 5.A.1.1 - - DsbC,DsbD,Thioredoxin_7 k59_1417473_1 99598.Cal7507_3494 4.71e-08 54.3 COG0102@1|root,COG0102@2|Bacteria,1G512@1117|Cyanobacteria,1HJF2@1161|Nostocales 1117|Cyanobacteria J This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly rplM GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02871 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L13 k59_1417473_2 1384054.N790_06705 8.86e-26 105.0 COG4973@1|root,COG4973@2|Bacteria,1MUJJ@1224|Proteobacteria,1RMJG@1236|Gammaproteobacteria,1X31C@135614|Xanthomonadales 135614|Xanthomonadales L Belongs to the 'phage' integrase family. XerC subfamily xerC - - ko:K03733 - - - - ko00000,ko03036 - - - Phage_int_SAM_1,Phage_integrase k59_570208_2 929712.KI912613_gene3442 2.25e-18 83.2 2EE69@1|root,3380V@2|Bacteria,2GR09@201174|Actinobacteria,4CTGN@84995|Rubrobacteria 84995|Rubrobacteria - - - - - - - - - - - - - - - k59_1643798_2 1229909.NSED_06640 1.68e-46 156.0 COG4742@1|root,arCOG04362@2157|Archaea,41SGE@651137|Thaumarchaeota 651137|Thaumarchaeota K Transcriptional regulator - - - - - - - - - - - - HTH_20,HTH_5 k59_1700097_1 1449346.JQMO01000003_gene6291 1.38e-18 89.7 COG1162@1|root,COG1162@2|Bacteria,2GMDX@201174|Actinobacteria,2M174@2063|Kitasatospora 201174|Actinobacteria S One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit rsgA - 3.1.3.100 ko:K06949 ko00730,ko01100,map00730,map01100 - R00615,R02135 RC00002,RC00017 ko00000,ko00001,ko01000,ko03009 - - - RsgA_GTPase k59_1700097_2 35760.BCHO_0517 1.67e-27 109.0 COG0626@1|root,COG0626@2|Bacteria,2GJ5S@201174|Actinobacteria,4CYY2@85004|Bifidobacteriales 201174|Actinobacteria E Cys/Met metabolism PLP-dependent enzyme metB GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0003962,GO:0004123,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006534,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009070,GO:0009086,GO:0009092,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016765,GO:0016829,GO:0016846,GO:0017144,GO:0019279,GO:0019343,GO:0019344,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071265,GO:0071266,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.5.1.48 ko:K01739 ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00270,map00450,map00920,map01100,map01110,map01130,map01230 M00017 R00999,R01288,R02508,R03217,R03260,R04944,R04945,R04946 RC00020,RC00056,RC00069,RC00420,RC02848,RC02866 ko00000,ko00001,ko00002,ko01000 - - iNJ661.Rv1079 Cys_Met_Meta_PP k59_288082_1 316407.85676779 3.59e-104 303.0 28M8B@1|root,2ZAMG@2|Bacteria,1N1VT@1224|Proteobacteria,1RMP6@1236|Gammaproteobacteria,3XNZQ@561|Escherichia 1236|Gammaproteobacteria M extracellular polysaccharide metabolic process yjbF GO:0000271,GO:0005975,GO:0005976,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016051,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0045226,GO:0046379,GO:0071704,GO:1901576 - - - - - - - - - - YjbF k59_288082_2 316407.85676780 1.09e-122 353.0 29T7B@1|root,2ZAUX@2|Bacteria,1QUFK@1224|Proteobacteria,1T1X9@1236|Gammaproteobacteria,3XRNE@561|Escherichia 1236|Gammaproteobacteria S extracellular polysaccharide metabolic process yjbG GO:0000271,GO:0005975,GO:0005976,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016051,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0045226,GO:0046379,GO:0071704,GO:1901576 - - - - - - - - - - Caps_synth_GfcC k59_1135139_1 436308.Nmar_0748 1.81e-100 311.0 COG0480@1|root,arCOG01559@2157|Archaea,41S9B@651137|Thaumarchaeota 651137|Thaumarchaeota J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome fusA - - ko:K03234 ko04152,ko04921,map04152,map04921 - - - ko00000,ko00001,ko03012,ko04147 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2 k59_344576_1 498211.CJA_0692 5.6e-96 310.0 COG0085@1|root,COG0085@2|Bacteria,1MUC4@1224|Proteobacteria,1RMK0@1236|Gammaproteobacteria,1FH46@10|Cellvibrio 1236|Gammaproteobacteria K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoB GO:0000428,GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0030880,GO:0032774,GO:0032991,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234 2.7.7.6 ko:K03043 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7 k59_175008_2 595537.Varpa_2019 2.18e-17 80.9 2EBGC@1|root,335GX@2|Bacteria,1NC6Y@1224|Proteobacteria,2VWRZ@28216|Betaproteobacteria,4AIIQ@80864|Comamonadaceae 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_796406_1 596323.HMPREF0554_0394 0.000133 45.1 COG0217@1|root,COG0217@2|Bacteria,3787I@32066|Fusobacteria 32066|Fusobacteria K Transcriptional regulatory protein - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - - - - - - - - - - Transcrip_reg k59_796406_2 484770.UFO1_1892 7.39e-40 139.0 COG0817@1|root,COG0817@2|Bacteria,1V3N9@1239|Firmicutes,4H40U@909932|Negativicutes 909932|Negativicutes L Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group ruvC - 3.1.22.4 ko:K01159 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - RuvC k59_852868_1 1397528.Q671_04345 4.49e-15 81.3 COG0591@1|root,COG4191@1|root,COG0591@2|Bacteria,COG4191@2|Bacteria,1QTSW@1224|Proteobacteria,1T1G2@1236|Gammaproteobacteria,1XHSP@135619|Oceanospirillales 135619|Oceanospirillales T Histidine kinase - - - - - - - - - - - - HATPase_c,HisKA,PAS k59_570214_2 1198114.AciX9_1515 3.65e-06 52.4 COG0514@1|root,COG0514@2|Bacteria,3Y363@57723|Acidobacteria,2JHID@204432|Acidobacteriia 204432|Acidobacteriia L TIGRFAM ATP-dependent DNA helicase, RecQ family - - 3.6.4.12 ko:K03654 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,HRDC,Helicase_C,RecQ_Zn_bind k59_62131_1 1122137.AQXF01000002_gene270 1.07e-172 492.0 COG2234@1|root,COG2234@2|Bacteria,1MWBX@1224|Proteobacteria,2U2RE@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Peptidase M28 - - - - - - - - - - - - Peptidase_M28 k59_1474239_1 330084.JNYZ01000020_gene4721 3.95e-33 131.0 COG0243@1|root,COG0243@2|Bacteria,2I8HX@201174|Actinobacteria,4E84M@85010|Pseudonocardiales 201174|Actinobacteria C Molybdopterin oxidoreductase Fe4S4 domain - - - - - - - - - - - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding k59_1530659_1 1123073.KB899241_gene2672 1.12e-91 281.0 COG0538@1|root,COG0538@2|Bacteria,1MW3J@1224|Proteobacteria,1RNMD@1236|Gammaproteobacteria,1X3IR@135614|Xanthomonadales 135614|Xanthomonadales C Isocitrate/isopropylmalate dehydrogenase - - 1.1.1.42 ko:K00031 ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146 M00009,M00010,M00173,M00740 R00267,R00268,R01899 RC00001,RC00084,RC00114,RC00626,RC02801 br01601,ko00000,ko00001,ko00002,ko01000 - - - CBS,Iso_dh k59_288094_1 1123256.KB907926_gene754 1.14e-68 232.0 COG0272@1|root,COG0272@2|Bacteria,1MV3R@1224|Proteobacteria,1RPAV@1236|Gammaproteobacteria,1X2ZU@135614|Xanthomonadales 135614|Xanthomonadales L DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA ligA GO:0003674,GO:0003824,GO:0003909,GO:0003911,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016874,GO:0016886,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360 6.5.1.2 ko:K01972 ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430 - R00382 RC00005 ko00000,ko00001,ko01000,ko03032,ko03400 - - - BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5 k59_288094_2 658655.HMPREF0988_02366 2.2e-10 63.2 COG0482@1|root,COG0482@2|Bacteria,1TPIZ@1239|Firmicutes,247YV@186801|Clostridia,27INP@186928|unclassified Lachnospiraceae 186801|Clostridia J Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 mnmA - 2.8.1.13 ko:K00566 ko04122,map04122 - R08700 RC02313,RC02315 ko00000,ko00001,ko01000,ko03016 - - - tRNA_Me_trans k59_288096_1 331869.BAL199_11536 2.44e-70 224.0 COG1804@1|root,COG1804@2|Bacteria,1MW1H@1224|Proteobacteria,2TR7D@28211|Alphaproteobacteria 28211|Alphaproteobacteria C carnitine dehydratase - - 5.1.99.4 ko:K01796 ko00120,ko01100,ko04146,map00120,map01100,map04146 M00104 R08734,R08739 RC02345 ko00000,ko00001,ko00002,ko01000 - - - CoA_transf_3 k59_1248244_1 522306.CAP2UW1_0537 9.29e-08 52.4 COG1530@1|root,COG1530@2|Bacteria,1MV65@1224|Proteobacteria,2VI3N@28216|Betaproteobacteria,1KPMZ@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria J Translation, ribosomal structure and biogenesis cafA - - ko:K08301 - - - - ko00000,ko01000,ko03009,ko03019 - - - RNase_E_G,S1 k59_1248244_2 266117.Rxyl_0238 3.21e-93 287.0 COG0154@1|root,COG0154@2|Bacteria,2GKPZ@201174|Actinobacteria,4CPJR@84995|Rubrobacteria 84995|Rubrobacteria J Belongs to the amidase family - - 3.5.1.4 ko:K01426 ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120 - R02540,R03096,R03180,R03909,R05551,R05590 RC00010,RC00100,RC00950,RC01025 ko00000,ko00001,ko01000 - - - Amidase k59_965661_1 1123401.JHYQ01000002_gene2716 1.21e-17 84.3 COG0664@1|root,COG0664@2|Bacteria,1QU34@1224|Proteobacteria,1T2BY@1236|Gammaproteobacteria,462UK@72273|Thiotrichales 72273|Thiotrichales T Ion channel - - - - - - - - - - - - Ion_trans k59_965661_2 314254.OA2633_04771 6.35e-08 53.5 COG0013@1|root,COG0013@2|Bacteria,1MU9A@1224|Proteobacteria,2TQV4@28211|Alphaproteobacteria,43X02@69657|Hyphomonadaceae 28211|Alphaproteobacteria J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain alaS GO:0003674,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016597,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.7 ko:K01872 ko00970,map00970 M00359,M00360 R03038 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DHHA1,tRNA-synt_2c,tRNA_SAD k59_1643831_1 349521.HCH_07072 2.97e-94 284.0 COG0224@1|root,COG0224@2|Bacteria,1MU28@1224|Proteobacteria,1RNWJ@1236|Gammaproteobacteria,1XHVC@135619|Oceanospirillales 135619|Oceanospirillales C Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex atpG - - ko:K02115 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt k59_1756545_1 876044.IMCC3088_2850 6.34e-83 259.0 COG0364@1|root,COG0364@2|Bacteria,1MUN0@1224|Proteobacteria,1RN76@1236|Gammaproteobacteria,1J4IF@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria G Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone zwf GO:0003674,GO:0003824,GO:0004345,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007267,GO:0008150,GO:0008152,GO:0009117,GO:0009372,GO:0009987,GO:0010699,GO:0016491,GO:0016614,GO:0016616,GO:0019318,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0023052,GO:0034641,GO:0042802,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0044764,GO:0046483,GO:0046496,GO:0051156,GO:0051186,GO:0051704,GO:0055086,GO:0055114,GO:0071704,GO:0072524,GO:1901135,GO:1901360,GO:1901564 1.1.1.363,1.1.1.49 ko:K00036 ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230 M00004,M00006,M00008 R00835,R02736,R10907 RC00001,RC00066 ko00000,ko00001,ko00002,ko01000,ko04147 - - e_coli_core.b1852,iAF1260.b1852,iBWG_1329.BWG_1666,iE2348C_1286.E2348C_1977,iEC042_1314.EC042_2019,iECABU_c1320.ECABU_c21130,iECDH10B_1368.ECDH10B_1993,iECDH1ME8569_1439.ECDH1ME8569_1798,iECED1_1282.ECED1_2057,iECIAI39_1322.ECIAI39_1198,iECNA114_1301.ECNA114_1899,iECO26_1355.ECO26_2690,iECP_1309.ECP_1796,iECSF_1327.ECSF_1710,iECUMN_1333.ECUMN_2149,iECW_1372.ECW_m2026,iEKO11_1354.EKO11_1918,iEcDH1_1363.EcDH1_1789,iEcE24377_1341.EcE24377A_2082,iEcHS_1320.EcHS_A1944,iEcSMS35_1347.EcSMS35_1335,iEcolC_1368.EcolC_1780,iG2583_1286.G2583_2304,iJO1366.b1852,iJR904.b1852,iLF82_1304.LF82_3733,iNRG857_1313.NRG857_09280,iSDY_1059.SDY_1138,iWFL_1372.ECW_m2026,iY75_1357.Y75_RS09725,iYL1228.KPN_02367,ic_1306.c2265 G6PD_C,G6PD_N k59_1643832_1 702113.PP1Y_AT5763 5.08e-100 304.0 COG3203@1|root,COG3203@2|Bacteria,1P7S0@1224|Proteobacteria,2U33N@28211|Alphaproteobacteria,2K1XC@204457|Sphingomonadales 204457|Sphingomonadales M Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane - - - - - - - - - - - - Porin_4 k59_1756547_1 551789.ATVJ01000002_gene3073 4.17e-62 195.0 COG5553@1|root,COG5553@2|Bacteria,1PNX4@1224|Proteobacteria,2UZQZ@28211|Alphaproteobacteria,43ZRM@69657|Hyphomonadaceae 28211|Alphaproteobacteria S Cysteine dioxygenase type I - - - - - - - - - - - - - k59_796427_1 1121878.AUGL01000006_gene564 2.46e-148 427.0 COG1228@1|root,COG1228@2|Bacteria,1MVAF@1224|Proteobacteria,1RQRP@1236|Gammaproteobacteria 1236|Gammaproteobacteria Q COG1228 Imidazolonepropionase and related amidohydrolases - - - - - - - - - - - - Amidohydro_1 k59_1643833_1 983920.Y88_3386 3.66e-96 291.0 COG1104@1|root,COG1104@2|Bacteria,1MU1C@1224|Proteobacteria,2TSQE@28211|Alphaproteobacteria,2KA2P@204457|Sphingomonadales 204457|Sphingomonadales E COG1104 Cysteine sulfinate desulfinase cysteine desulfurase and related enzymes - - - - - - - - - - - - Aminotran_5 k59_1304794_1 1125863.JAFN01000001_gene1933 3.77e-115 341.0 COG2256@1|root,COG2256@2|Bacteria,1MUVS@1224|Proteobacteria,42M9X@68525|delta/epsilon subdivisions,2WJ7E@28221|Deltaproteobacteria 28221|Deltaproteobacteria L AAA ATPase, central domain protein rarA - - ko:K07478 - - - - ko00000 - - - AAA,AAA_assoc_2,MgsA_C,RuvB_N k59_965672_1 1379270.AUXF01000004_gene3295 3.44e-24 106.0 COG0354@1|root,COG0354@2|Bacteria,1ZTMX@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Glycine cleavage T-protein C-terminal barrel domain - - - ko:K06980 - - - - ko00000,ko03016 - - - GCV_T,GCV_T_C k59_570239_1 649638.Trad_0673 1.64e-05 51.2 COG0406@1|root,COG0406@2|Bacteria,1WJ6S@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus G phosphoglycerate mutase family - - - - - - - - - - - - His_Phos_1 k59_344629_1 1121912.AUHD01000006_gene1376 7.15e-12 66.6 COG1972@1|root,COG1972@2|Bacteria,4NEYN@976|Bacteroidetes,1HY0T@117743|Flavobacteriia 976|Bacteroidetes F nucleoside transporter nupC - - ko:K03317 - - - - ko00000 2.A.41 - - Gate,Nucleos_tra2_C,Nucleos_tra2_N k59_344629_2 1137281.D778_02252 8.17e-68 210.0 COG1259@1|root,COG1259@2|Bacteria,4NGSW@976|Bacteroidetes,1HXCB@117743|Flavobacteriia 976|Bacteroidetes S UvrB UvrC - - - ko:K08999 - - - - ko00000 - - - DNase-RNase,UVR k59_683178_1 1123392.AQWL01000005_gene3242 5.26e-65 211.0 28JAH@1|root,2Z95A@2|Bacteria,1MXKT@1224|Proteobacteria,2VI69@28216|Betaproteobacteria,1KSWZ@119069|Hydrogenophilales 119069|Hydrogenophilales S Uncharacterised nucleotidyltransferase - - - - - - - - - - - - NTP_transf_5 k59_5455_2 387344.LVIS_1979 1.33e-08 54.7 COG4576@1|root,COG4576@2|Bacteria,1VEI4@1239|Firmicutes,4HNX2@91061|Bacilli,3F83B@33958|Lactobacillaceae 91061|Bacilli CQ Ethanolamine utilisation protein EutN/carboxysome pduN - - ko:K04028 - - - - ko00000 - - - EutN_CcmL k59_5455_4 561231.Pecwa_4095 6.15e-22 95.5 COG1012@1|root,COG1012@2|Bacteria,1QUBI@1224|Proteobacteria,1RP7H@1236|Gammaproteobacteria,1MRRK@122277|Pectobacterium 1236|Gammaproteobacteria C Aldehyde dehydrogenase family pduP - 1.2.1.87 ko:K04021,ko:K13922 ko00620,ko00640,ko01100,ko01120,map00620,map00640,map01100,map01120 - R00228,R09097 RC00004,RC00184,RC01195 ko00000,ko00001,ko01000 - - iAPECO1_1312.APECO1_2291,iECED1_1282.ECED1_3458 Aldedh k59_1191933_1 1117647.M5M_10465 4.36e-96 300.0 COG2304@1|root,COG2304@2|Bacteria,1MUTS@1224|Proteobacteria,1RQPC@1236|Gammaproteobacteria,1J5KZ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S protein containing a von Willebrand factor type A (vWA) domain yfbK - - ko:K07114 - - - - ko00000,ko02000 1.A.13.2.2,1.A.13.2.3 - - DUF3520,VWA,vWF_A k59_344647_1 365046.Rta_34230 4.67e-10 59.7 COG0367@1|root,COG0367@2|Bacteria,1MW4E@1224|Proteobacteria,2VHBY@28216|Betaproteobacteria,4A9JC@80864|Comamonadaceae 28216|Betaproteobacteria E Asparagine synthase, glutamine-hydrolyzing - - 6.3.5.4 ko:K01953 ko00250,ko01100,ko01110,map00250,map01100,map01110 - R00578 RC00010 ko00000,ko00001,ko01000,ko01002 - - - Asn_synthase,GATase_7 k59_344647_2 1547437.LL06_23025 2.4e-55 190.0 COG0189@1|root,COG0454@1|root,COG0189@2|Bacteria,COG0456@2|Bacteria,1MVN2@1224|Proteobacteria,2TUT9@28211|Alphaproteobacteria,43IKD@69277|Phyllobacteriaceae 28211|Alphaproteobacteria HJK FR47-like protein cphA - 6.3.2.29,6.3.2.30 ko:K03802 - - - - ko00000,ko01000 - - - Acetyltransf_1,Dala_Dala_lig_C,GSH-S_ATP,RimK k59_288151_1 1453501.JELR01000001_gene2270 6.25e-17 74.3 COG1862@1|root,COG1862@2|Bacteria,1MZT2@1224|Proteobacteria,1S9NV@1236|Gammaproteobacteria,467BH@72275|Alteromonadaceae 1236|Gammaproteobacteria U Preprotein translocase subunit YajC yajC GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0031522,GO:0032991,GO:0044425,GO:0044459,GO:0044464,GO:0071944 - ko:K03210 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2 - - YajC k59_288151_2 247633.GP2143_04008 2.49e-47 162.0 COG2515@1|root,COG2515@2|Bacteria,1MVYF@1224|Proteobacteria,1RMYP@1236|Gammaproteobacteria,1J4W1@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E COG2515 1-aminocyclopropane-1-carboxylate deaminase - - 4.4.1.15 ko:K05396 ko00270,map00270 - R01874 RC00382 ko00000,ko00001,ko01000 - - - PALP k59_1361316_1 1219045.BV98_001238 1.19e-13 70.5 COG1070@1|root,COG1070@2|Bacteria,1MUHF@1224|Proteobacteria,2TZ8V@28211|Alphaproteobacteria,2K1N5@204457|Sphingomonadales 204457|Sphingomonadales G Carbohydrate kinase - - - - - - - - - - - - FGGY_N k59_1361316_2 1219045.BV98_001236 6.68e-86 264.0 COG0477@1|root,COG0477@2|Bacteria,1MYYW@1224|Proteobacteria,2VC37@28211|Alphaproteobacteria,2K1BW@204457|Sphingomonadales 204457|Sphingomonadales EGP Sugar (and other) transporter - - - - - - - - - - - - MFS_1,Sugar_tr k59_1474305_1 1123256.KB907933_gene2297 6.25e-55 184.0 COG3852@1|root,COG3852@2|Bacteria,1MVN6@1224|Proteobacteria,1RN15@1236|Gammaproteobacteria,1X3AZ@135614|Xanthomonadales 135614|Xanthomonadales T Signal transduction histidine kinase, nitrogen specific ntrB - 2.7.13.3 ko:K07708 ko02020,map02020 M00497 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA,PAS,PAS_4 k59_1248287_1 1111732.AZOD01000004_gene1020 5.47e-19 86.7 COG0719@1|root,COG0719@2|Bacteria,1MVKY@1224|Proteobacteria,1RQ65@1236|Gammaproteobacteria,1X2XK@135614|Xanthomonadales 135614|Xanthomonadales O Cysteine desulfurase activator complex subunit SufB sufB - - ko:K09014 - - - - ko00000 - - - UPF0051 k59_1248287_2 574966.KB898649_gene304 0.000739 43.9 COG1959@1|root,COG1959@2|Bacteria,1N0E2@1224|Proteobacteria,1S915@1236|Gammaproteobacteria,1XMA5@135619|Oceanospirillales 135619|Oceanospirillales K transcriptional regulator - - - - - - - - - - - - Rrf2 k59_1417551_1 1215092.PA6_006_00030 3.44e-17 77.0 COG1516@1|root,COG1516@2|Bacteria,1MZ3G@1224|Proteobacteria,1S8TQ@1236|Gammaproteobacteria,1YGJ8@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria N flagellar protein FliS fliS - - ko:K02422 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - FliS k59_1700166_1 1536773.R70331_16370 2.27e-30 116.0 COG0127@1|root,COG0127@2|Bacteria 2|Bacteria F nucleoside triphosphate catabolic process rdgB GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009141,GO:0009143,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0055086,GO:0071704,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576 3.6.1.66,5.1.1.3 ko:K01776,ko:K02428 ko00230,ko00471,ko01100,map00230,map00471,map01100 - R00260,R00426,R00720,R01855,R02100,R02720,R03531 RC00002,RC00302 ko00000,ko00001,ko01000,ko01011 - - - Ham1p_like k59_683194_2 203267.TWT_123 3.68e-15 72.0 2CC1Y@1|root,32RUK@2|Bacteria,2IQ4Q@201174|Actinobacteria 201174|Actinobacteria K Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA whiB2 - - ko:K18955 - - - - ko00000,ko03000 - - - Whib k59_517748_2 1485544.JQKP01000002_gene1453 1.97e-29 116.0 COG0495@1|root,COG0495@2|Bacteria,1MV47@1224|Proteobacteria,2VH2J@28216|Betaproteobacteria,44V3Z@713636|Nitrosomonadales 28216|Betaproteobacteria J Belongs to the class-I aminoacyl-tRNA synthetase family leuS - 6.1.1.4 ko:K01869 ko00970,map00970 M00359,M00360 R03657 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - Anticodon_1,tRNA-synt_1,tRNA-synt_1_2 k59_235333_1 1122970.AUHC01000012_gene935 4.62e-55 193.0 COG2199@1|root,COG3706@2|Bacteria,1MW39@1224|Proteobacteria,2U25F@28211|Alphaproteobacteria,2KDVH@204457|Sphingomonadales 204457|Sphingomonadales T 7TM diverse intracellular signalling - - - - - - - - - - - - 7TMR-DISM_7TM,GGDEF k59_1704298_1 1232410.KI421413_gene574 2.03e-36 142.0 COG1404@1|root,COG1520@1|root,COG1404@2|Bacteria,COG1520@2|Bacteria,1MU3S@1224|Proteobacteria,42SPI@68525|delta/epsilon subdivisions 1224|Proteobacteria O COG1404 Subtilisin-like serine proteases - - 3.4.21.111 ko:K12685,ko:K20754 - - - - ko00000,ko01000,ko01002,ko02000,ko02044 1.B.12.5.1,1.B.12.5.3 - - Inhibitor_I9,Peptidase_S8 k59_1535057_1 436308.Nmar_0115 3.8e-284 782.0 COG1964@1|root,arCOG00933@2157|Archaea,41SAY@651137|Thaumarchaeota 651137|Thaumarchaeota S Radical SAM - - - ko:K06937 - - - - ko00000,ko01000 - - - Fer4_12,Radical_SAM k59_66679_1 330214.NIDE3447 2.96e-95 290.0 COG0156@1|root,COG0156@2|Bacteria,3J0XU@40117|Nitrospirae 2|Bacteria H Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide bioF GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008710,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016746,GO:0016747,GO:0017144,GO:0018130,GO:0019752,GO:0019842,GO:0030170,GO:0030312,GO:0032787,GO:0034641,GO:0036094,GO:0042364,GO:0043167,GO:0043168,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0070279,GO:0071704,GO:0071944,GO:0072330,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.3.1.29,2.3.1.47 ko:K00639,ko:K00652 ko00260,ko00780,ko01100,map00260,map00780,map01100 M00123,M00573,M00577 R00371,R03210,R10124 RC00004,RC00039,RC00394,RC02725 ko00000,ko00001,ko00002,ko01000,ko01007 - - iJN678.bioF,iNJ661.Rv1569 Aminotran_1_2 k59_857565_1 498211.CJA_0127 2.64e-62 216.0 COG3209@1|root,COG3210@1|root,COG3209@2|Bacteria,COG3210@2|Bacteria,1MVV1@1224|Proteobacteria,1RMPT@1236|Gammaproteobacteria,1FI4C@10|Cellvibrio 1236|Gammaproteobacteria M Insecticide toxin TcdB middle/N-terminal region - - - - - - - - - - - - RHS_repeat,SpvB,TcdB_toxin_midN,VCBS k59_687494_1 1229909.NSED_00895 2.64e-75 235.0 COG1180@1|root,arCOG00946@2157|Archaea,41SBZ@651137|Thaumarchaeota 651137|Thaumarchaeota C Radical SAM - - 1.97.1.4 ko:K04069 - - R04710 - ko00000,ko01000 - - - Radical_SAM k59_349092_2 436308.Nmar_1028 4.37e-102 306.0 COG1250@1|root,arCOG00249@2157|Archaea,41S92@651137|Thaumarchaeota 651137|Thaumarchaeota I 3-hydroxyacyl-CoA dehydrogenase - - 1.1.1.35,4.2.1.17 ko:K15016 ko00720,ko01120,ko01200,map00720,map01120,map01200 M00374,M00375 R01975,R03026 RC00117,RC00831 ko00000,ko00001,ko00002,ko01000 - - - 3HCDH,3HCDH_N k59_913546_1 316407.85675713 3.98e-162 463.0 COG2723@1|root,COG2723@2|Bacteria,1MWG6@1224|Proteobacteria,1RMM2@1236|Gammaproteobacteria,3XM82@561|Escherichia 1236|Gammaproteobacteria G Belongs to the glycosyl hydrolase 1 family bglA GO:0003674,GO:0003824,GO:0004553,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005984,GO:0008150,GO:0008152,GO:0008422,GO:0008706,GO:0009056,GO:0009311,GO:0009313,GO:0009987,GO:0015926,GO:0016052,GO:0016787,GO:0016798,GO:0044237,GO:0044238,GO:0044248,GO:0044262,GO:0044275,GO:0044424,GO:0044444,GO:0044464,GO:0046352,GO:0071704,GO:1901135,GO:1901575,GO:1901657,GO:2000891,GO:2000892 3.2.1.21,3.2.1.86 ko:K01223,ko:K05350 ko00010,ko00460,ko00500,ko00940,ko01100,ko01110,map00010,map00460,map00500,map00940,map01100,map01110 - R00026,R00839,R02558,R02887,R02985,R03527,R04949,R04998,R05133,R05134,R10035,R10039,R10040 RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248 ko00000,ko00001,ko01000 - GT1 iEC55989_1330.EC55989_3188,iSSON_1240.SSON_3054 Glyco_hydro_1 k59_801061_1 1415778.JQMM01000001_gene1552 7.25e-42 147.0 COG2035@1|root,COG2035@2|Bacteria,1MXVI@1224|Proteobacteria,1RN4B@1236|Gammaproteobacteria,1J5RK@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S membrane - - - ko:K08974 - - - - ko00000 - - - DUF368 k59_292597_1 391587.KAOT1_17323 1.75e-73 223.0 COG2128@1|root,COG2128@2|Bacteria,4NEJZ@976|Bacteroidetes,1HXPF@117743|Flavobacteriia 976|Bacteroidetes S carboxymuconolactone decarboxylase - - - - - - - - - - - - CMD k59_292597_2 1121012.AUKX01000003_gene1560 1.22e-33 120.0 COG1765@1|root,COG1765@2|Bacteria,4NNTY@976|Bacteroidetes,1I275@117743|Flavobacteriia,23H81@178469|Arenibacter 976|Bacteroidetes O OsmC-like protein - - - ko:K07397 - - - - ko00000 - - - OsmC k59_180074_1 500153.JOEK01000011_gene1919 4.65e-83 258.0 COG1219@1|root,COG1219@2|Bacteria,2GJXQ@201174|Actinobacteria 201174|Actinobacteria O ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP clpX GO:0000166,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005623,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030163,GO:0030312,GO:0030554,GO:0031333,GO:0032271,GO:0032272,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0040007,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0043254,GO:0044087,GO:0044238,GO:0044464,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051129,GO:0051301,GO:0065007,GO:0070011,GO:0071704,GO:0071944,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575 - ko:K03544 ko04112,map04112 - - - ko00000,ko00001,ko03110 - - - AAA_2,ClpB_D2-small,zf-C4_ClpX k59_1083996_1 330214.NIDE1309 3.17e-156 446.0 COG0050@1|root,COG0050@2|Bacteria,3J0DG@40117|Nitrospirae 40117|Nitrospirae J This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis - - - ko:K02358 - - - - ko00000,ko03012,ko03029,ko04147 - - - GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3 k59_858683_1 523791.Kkor_1514 3.11e-88 275.0 COG0644@1|root,COG2440@1|root,COG0644@2|Bacteria,COG2440@2|Bacteria,1MVU6@1224|Proteobacteria,1RNY5@1236|Gammaproteobacteria,1XHVH@135619|Oceanospirillales 135619|Oceanospirillales C Electron transfer flavoprotein-ubiquinone oxidoreductase etf - 1.5.5.1 ko:K00311 - - - - ko00000,ko01000 - - - ETF_QO,FAD_binding_2,NAD_binding_8 k59_1310294_1 1121937.AUHJ01000006_gene2480 1.96e-58 193.0 COG4240@1|root,COG4240@2|Bacteria,1QUTA@1224|Proteobacteria,1T23W@1236|Gammaproteobacteria,466GQ@72275|Alteromonadaceae 1236|Gammaproteobacteria S COG4240 Predicted kinase - - 2.7.1.31 ko:K15918 ko00260,ko00561,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00561,map00630,map01100,map01110,map01130,map01200 M00532 R01514 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - ArgK,PRK k59_1649048_1 1242864.D187_007372 7.94e-76 246.0 COG0443@1|root,COG0443@2|Bacteria,1MVEN@1224|Proteobacteria,42M64@68525|delta/epsilon subdivisions,2WIWS@28221|Deltaproteobacteria 28221|Deltaproteobacteria O Heat shock 70 kDa protein - - - ko:K04043 ko03018,ko04212,ko05152,map03018,map04212,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 1.A.33.1 - - HSP70 k59_1592163_1 436308.Nmar_1086 1.79e-120 354.0 COG0505@1|root,arCOG00064@2157|Archaea,41SF0@651137|Thaumarchaeota 651137|Thaumarchaeota E carbamoyl-phosphate synthase, small subunit carA - 6.3.5.5 ko:K01956 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - - CPSase_sm_chain,GATase k59_1366733_1 504487.JCM19302_209 3.37e-43 146.0 COG0745@1|root,COG0745@2|Bacteria,4NF1I@976|Bacteroidetes,1HYAN@117743|Flavobacteriia 976|Bacteroidetes T Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain rprY - - - - - - - - - - - Response_reg,Trans_reg_C k59_1366733_2 1046627.BZARG_2311 1.89e-145 424.0 COG0642@1|root,COG2205@2|Bacteria,4NEFW@976|Bacteroidetes,1HWJQ@117743|Flavobacteriia 976|Bacteroidetes T Histidine kinase rprX - 2.7.13.3 ko:K07636 ko02020,map02020 M00434 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA k59_1536137_2 1096930.L284_06775 4.61e-48 169.0 COG1524@1|root,COG1524@2|Bacteria,1R5V5@1224|Proteobacteria,2U1UW@28211|Alphaproteobacteria,2KDB4@204457|Sphingomonadales 204457|Sphingomonadales S Alkaline phosphatase with broad substrate specificity - - - - - - - - - - - - Phosphodiest k59_1762008_2 633149.Bresu_2130 5.03e-49 166.0 COG0788@1|root,COG0788@2|Bacteria,1MVCF@1224|Proteobacteria,2TR4V@28211|Alphaproteobacteria,2KFGR@204458|Caulobacterales 204458|Caulobacterales F Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4) purU - 3.5.1.10 ko:K01433 ko00630,ko00670,map00630,map00670 - R00944 RC00026,RC00111 ko00000,ko00001,ko01000 - - - ACT,Formyl_trans_N k59_688569_1 1498011.A0A096XUX6_9CAUD 2.31e-160 478.0 4QCZC@10239|Viruses,4QRH3@28883|Caudovirales 28883|Caudovirales S Bacterial DNA polymerase III alpha subunit - - - - - - - - - - - - - k59_970577_1 1121405.dsmv_2651 2.52e-90 281.0 COG5421@1|root,COG5421@2|Bacteria,1R3NX@1224|Proteobacteria,42QDV@68525|delta/epsilon subdivisions,2WIRQ@28221|Deltaproteobacteria,2MN1S@213118|Desulfobacterales 68525|delta/epsilon subdivisions L PFAM transposase IS4 family protein - - - - - - - - - - - - DDE_Tnp_1 k59_1592187_1 743720.Psefu_0052 2.32e-06 51.6 2DBDT@1|root,2Z8NY@2|Bacteria,1N7S2@1224|Proteobacteria,1RTZE@1236|Gammaproteobacteria,1YZIA@136845|Pseudomonas putida group 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_575424_1 977880.RALTA_A2884 2.29e-69 214.0 COG1463@1|root,COG1463@2|Bacteria,1NCUG@1224|Proteobacteria,2VRKR@28216|Betaproteobacteria,1K3MD@119060|Burkholderiaceae 28216|Betaproteobacteria Q PFAM Mammalian cell entry related domain protein mlaD - - ko:K02067 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - MlaD k59_575424_2 228410.NE2383 2.68e-08 54.3 COG0767@1|root,COG0767@2|Bacteria,1MVPN@1224|Proteobacteria,2VI5T@28216|Betaproteobacteria,3728G@32003|Nitrosomonadales 28216|Betaproteobacteria Q Permease MlaE ttg2B - - ko:K02066 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - MlaE k59_631966_1 1396418.BATQ01000125_gene5138 1.04e-52 182.0 COG2303@1|root,COG2303@2|Bacteria 2|Bacteria E choline dehydrogenase activity stsB - 1.1.99.21 ko:K08261 ko00051,map00051 - R02925 RC00102 ko00000,ko00001,ko01000 - - - GMC_oxred_C,GMC_oxred_N k59_1762021_1 13037.EHJ72108 2.99e-12 72.4 2A2VB@1|root,2RY3V@2759|Eukaryota,3A0K8@33154|Opisthokonta,3BPKW@33208|Metazoa,3D6WU@33213|Bilateria,42ARU@6656|Arthropoda,3T053@50557|Insecta,442UM@7088|Lepidoptera 33208|Metazoa S Cyclic nucleotide-monophosphate binding domain - - - - - - - - - - - - cNMP_binding k59_67776_1 1232410.KI421412_gene68 1.16e-25 105.0 COG4399@1|root,COG4399@2|Bacteria,1R42C@1224|Proteobacteria,42Q2W@68525|delta/epsilon subdivisions,2WJIA@28221|Deltaproteobacteria,43S0C@69541|Desulfuromonadales 28221|Deltaproteobacteria S Protein of unknown function (DUF445) - - - - - - - - - - - - DUF445 k59_67776_2 998674.ATTE01000001_gene4014 1.75e-19 90.5 COG1593@1|root,COG1593@2|Bacteria,1MUQE@1224|Proteobacteria,1RY6X@1236|Gammaproteobacteria 1236|Gammaproteobacteria G Malonyl-CoA decarboxylase - - 4.1.1.9 ko:K01578 ko00410,ko00640,ko01100,ko04146,ko04152,map00410,map00640,map01100,map04146,map04152 - R00233 RC00040 ko00000,ko00001,ko01000 - - - MCD,MCD_N k59_1480145_1 1267535.KB906767_gene4899 1.63e-23 100.0 COG0500@1|root,COG2226@2|Bacteria,3Y5QZ@57723|Acidobacteria,2JNVC@204432|Acidobacteriia 204432|Acidobacteriia Q Methyltransferase domain - - - - - - - - - - - - Methyltransf_11 k59_1705346_1 543728.Vapar_4487 1.44e-125 375.0 COG0028@1|root,COG0028@2|Bacteria,1MXDW@1224|Proteobacteria,2VHRD@28216|Betaproteobacteria,4ABWV@80864|Comamonadaceae 28216|Betaproteobacteria EH Belongs to the TPP enzyme family oxc - 4.1.1.8 ko:K01577 ko00630,ko01100,map00630,map01100 - R01908 RC00620 ko00000,ko00001,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_180116_1 768706.Desor_5313 5.44e-08 58.2 COG0860@1|root,COG2247@1|root,COG0860@2|Bacteria,COG2247@2|Bacteria,1V6BP@1239|Firmicutes,25B61@186801|Clostridia,264HP@186807|Peptococcaceae 186801|Clostridia M cell wall binding repeat 2 - - 3.5.1.28 ko:K01448 ko01503,map01503 M00727 R04112 RC00064,RC00141 ko00000,ko00001,ko00002,ko01000,ko01011,ko03036 - - - Amidase_3,CW_binding_2 k59_1705351_1 649638.Trad_1493 6.9e-05 50.4 COG0589@1|root,COG0589@2|Bacteria,1WMQ9@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus T PFAM Universal stress protein family - - - - - - - - - - - - Usp k59_1705351_2 926569.ANT_30960 1.99e-38 137.0 COG1951@1|root,COG1951@2|Bacteria,2G6YI@200795|Chloroflexi 200795|Chloroflexi C Fumarate hydratase (Fumerase) - - 4.2.1.2 ko:K01676,ko:K01677 ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374,M00620 R01082 RC00443 ko00000,ko00001,ko00002,ko01000 - - - Fumerase k59_236382_1 996637.SGM_4430 1.12e-75 251.0 COG1123@1|root,COG4172@2|Bacteria,2H3HY@201174|Actinobacteria 201174|Actinobacteria O Belongs to the ABC transporter superfamily - - - ko:K02031,ko:K02032 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - ABC_tran,oligo_HPY k59_11006_1 981384.AEYW01000001_gene1602 1.1e-67 222.0 28HMZ@1|root,2Z7WD@2|Bacteria,1MU3Q@1224|Proteobacteria,2TSGX@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Protein of unknown function (DUF3604) - - - - - - - - - - - - DUF3604 k59_970628_1 391603.FBALC1_17097 1.56e-50 167.0 2959I@1|root,2ZSMW@2|Bacteria,4NP9F@976|Bacteroidetes,1I2KQ@117743|Flavobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_632007_1 1177154.Y5S_01705 1.35e-86 288.0 COG2885@1|root,COG2885@2|Bacteria,1QW22@1224|Proteobacteria,1T4AK@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Ompa motb domain protein - - - - - - - - - - - - DUF11,OmpA k59_236395_1 909613.UO65_3480 3.1e-13 68.2 COG2301@1|root,COG2301@2|Bacteria,2GK5J@201174|Actinobacteria,4E0H5@85010|Pseudonocardiales 201174|Actinobacteria G HpcH/HpaI aldolase/citrate lyase family - - 4.1.3.24,4.1.3.25 ko:K08691 ko00630,ko00660,ko00680,ko00720,ko01120,ko01200,map00630,map00660,map00680,map00720,map01120,map01200 M00346,M00373,M00376 R00237,R00473,R00934 RC00307,RC00308,RC00311,RC00407,RC00502,RC01205 ko00000,ko00001,ko00002,ko01000 - - - HpcH_HpaI k59_236395_2 317936.Nos7107_4358 3.18e-12 67.0 COG1858@1|root,COG1858@2|Bacteria,1G1X0@1117|Cyanobacteria 1117|Cyanobacteria C cytochrome C peroxidase - - - - - - - - - - - - Cytochrom_C,Cytochrome_CBB3 k59_632008_1 316407.85676044 4.1e-109 331.0 COG2199@1|root,COG2200@1|root,COG2199@2|Bacteria,COG2200@2|Bacteria,1MUQV@1224|Proteobacteria,1RN0Q@1236|Gammaproteobacteria,3XMX0@561|Escherichia 1236|Gammaproteobacteria T Serves as a specificity factor required for RNase E- mediated decay of the small global regulatory RNAs CsrB and CsrC, it is probably not a nuclease. Nor does its activity involve c-di- GMP, despite its domain composition. Positively modulates motility gene expression, is also required for curli expression csrD GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016020,GO:0016043,GO:0016070,GO:0019219,GO:0019222,GO:0019439,GO:0022607,GO:0031323,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044464,GO:0046483,GO:0046700,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0060255,GO:0065003,GO:0065007,GO:0071704,GO:0071840,GO:0071944,GO:0080090,GO:0090304,GO:1901360,GO:1901361,GO:1901575 - ko:K18765 - - - - ko00000,ko03019 - - - EAL,GAPES4,GGDEF k59_1536174_1 760117.JN27_19035 3.76e-38 140.0 COG4324@1|root,COG4324@2|Bacteria,1N0FE@1224|Proteobacteria,2VH73@28216|Betaproteobacteria,476PV@75682|Oxalobacteraceae 28216|Betaproteobacteria S Putative aminopeptidase - - - - - - - - - - - - Aminopep k59_858772_1 580327.Tthe_1586 1.85e-23 97.8 COG1116@1|root,COG1116@2|Bacteria,1TRM6@1239|Firmicutes,248CG@186801|Clostridia 186801|Clostridia P ABC-type nitrate sulfonate bicarbonate transport system ATPase component - - - ko:K02049 - M00188 - - ko00000,ko00002,ko02000 3.A.1.16,3.A.1.17 - - ABC_tran k59_802059_2 357808.RoseRS_1993 1.65e-11 62.0 2DQJV@1|root,337C3@2|Bacteria 2|Bacteria S Protein of unknown function (DUF2442) - - - - - - - - - - - - DUF2442 k59_970646_1 316407.85676979 1.58e-110 330.0 COG1129@1|root,COG1129@2|Bacteria,1MU22@1224|Proteobacteria,1RMCH@1236|Gammaproteobacteria,3XMNV@561|Escherichia 1236|Gammaproteobacteria P ABC transporter, ATP-binding protein ytfR GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005354,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0005996,GO:0006810,GO:0006950,GO:0006974,GO:0008144,GO:0008150,GO:0008152,GO:0008643,GO:0008645,GO:0009987,GO:0015144,GO:0015145,GO:0015146,GO:0015148,GO:0015149,GO:0015399,GO:0015405,GO:0015407,GO:0015591,GO:0015592,GO:0015749,GO:0015750,GO:0015752,GO:0015753,GO:0015757,GO:0015765,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019321,GO:0022804,GO:0022857,GO:0030554,GO:0031224,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033554,GO:0034219,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042732,GO:0043167,GO:0043168,GO:0043190,GO:0043211,GO:0043492,GO:0044238,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051119,GO:0051179,GO:0051234,GO:0051716,GO:0055085,GO:0071702,GO:0071704,GO:0071944,GO:0097159,GO:0097367,GO:0098533,GO:0098796,GO:0098797,GO:1901264,GO:1901265,GO:1901363,GO:1901505,GO:1901656,GO:1902494,GO:1902495,GO:1904949,GO:1990351 3.6.3.17 ko:K02056,ko:K10441,ko:K10542,ko:K10545,ko:K10551 ko02010,map02010 M00212,M00214,M00215,M00217,M00221 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.2,3.A.1.2.1,3.A.1.2.13,3.A.1.2.19,3.A.1.2.3,3.A.1.2.4,3.A.1.2.6 - iEC55989_1330.EC55989_4224,iECED1_1282.ECED1_4821,iECED1_1282.ECED1_5085,iECH74115_1262.ECH74115_3282,iECNA114_1301.ECNA114_4270,iECSE_1348.ECSE_4039,iECSP_1301.ECSP_3027,iECW_1372.ECW_m4052,iEcE24377_1341.EcE24377A_4265,iSF_1195.SF3611,iS_1188.S4158,iWFL_1372.ECW_m4052 ABC_tran k59_1592225_1 498761.HM1_2138 6.85e-22 99.8 COG0515@1|root,COG2815@1|root,COG0515@2|Bacteria,COG2815@2|Bacteria,1TP3F@1239|Firmicutes,2492G@186801|Clostridia 186801|Clostridia KLT serine threonine protein kinase prkC - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - PASTA,Pkinase k59_1592225_2 1298593.TOL_0241 1.82e-19 91.3 COG1639@1|root,COG1639@2|Bacteria,1MXVB@1224|Proteobacteria 1224|Proteobacteria T Signal transduction protein - - - - - - - - - - - - HDOD k59_406139_1 436308.Nmar_0880 9.05e-29 108.0 arCOG02103@1|root,arCOG02103@2157|Archaea,41T51@651137|Thaumarchaeota 651137|Thaumarchaeota S Domain of unknown function (DUF4443) - - - - - - - - - - - - DUF4443 k59_406139_2 436308.Nmar_0879 8.26e-37 124.0 arCOG08746@1|root,arCOG08746@2157|Archaea,41SWA@651137|Thaumarchaeota 651137|Thaumarchaeota S Probable cobalt transporter subunit (CbtB) - - - - - - - - - - - - CbtB k59_1197216_1 158500.BV97_02089 7.5e-10 56.6 COG3827@1|root,COG3827@2|Bacteria,1MX61@1224|Proteobacteria,2TSG8@28211|Alphaproteobacteria,2K7EP@204457|Sphingomonadales 204457|Sphingomonadales S protein conserved in bacteria - - - ko:K09991 - - - - ko00000 - - - DUF2497 k59_1197216_2 1144305.PMI02_04238 2.42e-39 135.0 COG0824@1|root,COG0824@2|Bacteria,1NBU7@1224|Proteobacteria,2UF7N@28211|Alphaproteobacteria,2K6GH@204457|Sphingomonadales 204457|Sphingomonadales S Thioesterase-like superfamily - - - ko:K07107 - - - - ko00000,ko01000 - - - 4HBT,4HBT_2 k59_350168_1 314254.OA2633_11435 2.03e-101 323.0 COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,2TRWM@28211|Alphaproteobacteria,43ZKA@69657|Hyphomonadaceae 28211|Alphaproteobacteria P Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K15726 - - - - ko00000,ko02000 2.A.6.1.2 - - ACR_tran k59_11035_1 396588.Tgr7_0768 4.53e-41 150.0 COG0772@1|root,COG0772@2|Bacteria,1MVDB@1224|Proteobacteria,1RMIV@1236|Gammaproteobacteria,1WWCK@135613|Chromatiales 135613|Chromatiales M Peptidoglycan polymerase that is essential for cell division ftsW - - ko:K03588 ko04112,map04112 - - - ko00000,ko00001,ko02000,ko03036 2.A.103.1 - - FTSW_RODA_SPOVE k59_11035_2 257313.BP3025 5.27e-14 72.0 COG0771@1|root,COG0771@2|Bacteria,1MVYD@1224|Proteobacteria,2VHJ1@28216|Betaproteobacteria,3T1TK@506|Alcaligenaceae 28216|Betaproteobacteria M Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) murD - 6.3.2.9 ko:K01925 ko00471,ko00550,ko01100,map00471,map00550,map01100 - R02783 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase_C,Mur_ligase_M k59_1592234_1 436308.Nmar_1319 3.85e-17 78.2 COG0863@1|root,arCOG00115@2157|Archaea,41SZP@651137|Thaumarchaeota 651137|Thaumarchaeota L DNA methylase - - 2.1.1.113,2.1.1.72 ko:K00571,ko:K00590 - - - - ko00000,ko01000,ko02048 - - - N6_N4_Mtase k59_1592234_2 1229909.NSED_07310 1.5e-33 128.0 COG1205@1|root,arCOG08693@1|root,arCOG00555@2157|Archaea,arCOG08693@2157|Archaea,41SZS@651137|Thaumarchaeota 651137|Thaumarchaeota L DEAD DEAH box helicase - - - ko:K06877 - - - - ko00000 - - - DEAD,DUF1998,Helicase_C k59_1592243_1 626887.J057_13006 4.43e-83 254.0 COG0053@1|root,COG0053@2|Bacteria,1MVH8@1224|Proteobacteria,1RQ3E@1236|Gammaproteobacteria,46BQ5@72275|Alteromonadaceae 1236|Gammaproteobacteria U Cation efflux family catA - - - - - - - - - - - Cation_efflux,ZT_dimer k59_11041_1 997346.HMPREF9374_2409 0.000162 43.9 COG0216@1|root,COG0216@2|Bacteria,1TQ7V@1239|Firmicutes,4H9MB@91061|Bacilli,27BMW@186824|Thermoactinomycetaceae 91061|Bacilli J PCRF prfA - - ko:K02835 - - - - ko00000,ko03012 - - - PCRF,RF-1 k59_11041_2 314230.DSM3645_21874 6.29e-31 120.0 COG2890@1|root,COG2890@2|Bacteria,2IYX6@203682|Planctomycetes 203682|Planctomycetes J Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif prmC GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0008168,GO:0008757,GO:0016740,GO:0016741,GO:0032259,GO:0044424,GO:0044444,GO:0044464 2.1.1.297 ko:K02493 - - R10806 RC00003,RC03279 ko00000,ko01000,ko03012 - - - MTS k59_1253916_1 1202962.KB907169_gene2494 8.56e-57 196.0 COG0437@1|root,COG3302@1|root,COG0437@2|Bacteria,COG3302@2|Bacteria,1MU1B@1224|Proteobacteria,1SYHX@1236|Gammaproteobacteria 1236|Gammaproteobacteria C reductase chain B - - - ko:K07307 ko00920,map00920 - R09501 RC02555 ko00000,ko00001,ko02000 5.A.3.3 - - DmsC,Fer4_11,Fer4_4 k59_1592258_1 768066.HELO_3823 6.19e-60 194.0 COG0266@1|root,COG0266@2|Bacteria,1MVM5@1224|Proteobacteria,1RP3J@1236|Gammaproteobacteria,1XH8W@135619|Oceanospirillales 135619|Oceanospirillales L Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates fpg - 3.2.2.23,4.2.99.18 ko:K10563 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - Fapy_DNA_glyco,H2TH,zf-FPG_IleRS k59_1592258_2 264730.PSPPH_4789 6.1e-34 122.0 COG0669@1|root,COG0669@2|Bacteria,1RD9F@1224|Proteobacteria,1S41J@1236|Gammaproteobacteria,1Z5I7@136849|Pseudomonas syringae group 1236|Gammaproteobacteria F Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate coaD GO:0003674,GO:0003824,GO:0004595,GO:0005488,GO:0005515,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0070566,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.7.3 ko:K00954 ko00770,ko01100,map00770,map01100 M00120 R03035 RC00002 ko00000,ko00001,ko00002,ko01000 - - iPC815.YPO0053,iSDY_1059.SDY_4064 CTP_transf_like k59_1762077_1 1144305.PMI02_02494 5.67e-05 44.3 COG1434@1|root,COG1434@2|Bacteria,1RHMV@1224|Proteobacteria,2U957@28211|Alphaproteobacteria,2K4KS@204457|Sphingomonadales 204457|Sphingomonadales S DUF218 domain - - - - - - - - - - - - DUF218 k59_1762077_2 158500.BV97_02389 2.27e-67 212.0 COG0204@1|root,COG0204@2|Bacteria,1MY51@1224|Proteobacteria,2TT3P@28211|Alphaproteobacteria,2K3XJ@204457|Sphingomonadales 204457|Sphingomonadales I Acyltransferase plsC - 2.3.1.51 ko:K00655 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R02241,R09381 RC00004,RC00037,RC00039 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Acyltransferase k59_802077_1 908340.HMPREF9406_3523 2.43e-30 117.0 COG2227@1|root,COG2227@2|Bacteria,1TR7Z@1239|Firmicutes,248FI@186801|Clostridia,36HGC@31979|Clostridiaceae 186801|Clostridia H Methyltransferase domain - - - - - - - - - - - - Methyltransf_11,Methyltransf_25 k59_688659_1 1384054.N790_01945 1.06e-200 593.0 COG2352@1|root,COG2352@2|Bacteria,1MUD5@1224|Proteobacteria,1RPTP@1236|Gammaproteobacteria,1X4MI@135614|Xanthomonadales 135614|Xanthomonadales C Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle ppc GO:0003674,GO:0003824,GO:0004611,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008964,GO:0016829,GO:0016830,GO:0016831,GO:0044424,GO:0044444,GO:0044464 4.1.1.31 ko:K01595 ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200 M00168,M00170,M00171,M00172,M00173,M00346,M00374 R00345 RC02741 ko00000,ko00001,ko00002,ko01000 - - - PEPcase k59_688659_2 3218.PP1S98_210V6.1 7.96e-08 60.5 28I0W@1|root,2QQBM@2759|Eukaryota,37QCD@33090|Viridiplantae,3GDH6@35493|Streptophyta 35493|Streptophyta - - - - - - - - - - - - - - - k59_1480239_1 867900.Celly_0490 0.000267 41.6 COG1832@1|root,COG1832@2|Bacteria,4NSE8@976|Bacteroidetes,1I2XU@117743|Flavobacteriia,1F9JG@104264|Cellulophaga 976|Bacteroidetes S CoA binding domain - - - ko:K06929 - - - - ko00000 - - - CoA_binding_2 k59_1480239_2 641526.ADIWIN_2876 5.79e-49 176.0 COG1629@1|root,COG4771@2|Bacteria,4NEIG@976|Bacteroidetes,1HXUG@117743|Flavobacteriia 976|Bacteroidetes P TonB-dependent receptor - - - - - - - - - - - - CarbopepD_reg_2,OMP_b-brl_3,Plug k59_914652_1 880072.Desac_0492 6.18e-59 208.0 COG0784@1|root,COG2203@1|root,COG4191@1|root,COG5000@1|root,COG0784@2|Bacteria,COG2203@2|Bacteria,COG4191@2|Bacteria,COG5000@2|Bacteria,1RCM9@1224|Proteobacteria,42M1R@68525|delta/epsilon subdivisions,2WK3J@28221|Deltaproteobacteria,2MSIC@213462|Syntrophobacterales 28221|Deltaproteobacteria T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg,SBP_bac_3 k59_1034787_1 373903.Hore_06940 9.03e-46 166.0 COG0297@1|root,COG1555@1|root,COG0297@2|Bacteria,COG1555@2|Bacteria,1TQ4M@1239|Firmicutes,248G1@186801|Clostridia,3WB77@53433|Halanaerobiales 186801|Clostridia G Synthesizes alpha-1,4-glucan chains using ADP-glucose glgA - 2.4.1.21 ko:K00703 ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026 M00565 R02421 RC00005 ko00000,ko00001,ko00002,ko01000,ko01003 - GT5 - Glyco_transf_5,Glycos_transf_1,HHH_3 k59_581772_1 660470.Theba_1302 6.2e-43 147.0 COG0745@1|root,COG0745@2|Bacteria,2GCWP@200918|Thermotogae 200918|Thermotogae K PFAM response regulator receiver - - - - - - - - - - - - Response_reg,Trans_reg_C k59_694706_1 1121912.AUHD01000022_gene254 2.45e-89 269.0 COG0275@1|root,COG0275@2|Bacteria,4NFQB@976|Bacteroidetes,1HWZ0@117743|Flavobacteriia 976|Bacteroidetes J Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA rsmH GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0070475,GO:0071424,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.199 ko:K03438 - - - - ko00000,ko01000,ko03009 - - - Methyltransf_5 k59_1768118_1 1131266.ARWQ01000001_gene1353 1.86e-20 86.7 COG1514@1|root,arCOG01736@2157|Archaea,41SP7@651137|Thaumarchaeota 651137|Thaumarchaeota J Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester - - 3.1.4.58 ko:K01975 - - - - ko00000,ko01000,ko03016 - - - LigT_PEase k59_1768118_2 436308.Nmar_1782 5.86e-127 374.0 COG1746@1|root,arCOG04249@2157|Archaea,41S76@651137|Thaumarchaeota 651137|Thaumarchaeota J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate cca - 2.7.7.72 ko:K07558 - - R09382,R09383,R09384,R09386 RC00078 ko00000,ko01000,ko03016 - - - NTP_transf_2,tRNA_NucTransf2 k59_186824_1 1453501.JELR01000001_gene3051 6.84e-89 280.0 COG0768@1|root,COG0768@2|Bacteria,1MUNY@1224|Proteobacteria,1RNGW@1236|Gammaproteobacteria,4650A@72275|Alteromonadaceae 1236|Gammaproteobacteria M Catalyzes cross-linking of the peptidoglycan cell wall at the division septum ftsI GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008144,GO:0008150,GO:0008658,GO:0008955,GO:0009987,GO:0016020,GO:0016021,GO:0016740,GO:0016757,GO:0016758,GO:0031224,GO:0031226,GO:0031406,GO:0032153,GO:0033218,GO:0033293,GO:0036094,GO:0042221,GO:0042493,GO:0043167,GO:0043168,GO:0043177,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051301,GO:0071944,GO:0097159,GO:1901363,GO:1901681 3.4.16.4 ko:K03587 ko00550,ko01501,map00550,map01501 - - - ko00000,ko00001,ko01000,ko01011,ko03036 - - iSSON_1240.SSON_0092 PBP_dimer,Transpeptidase k59_1146491_1 382464.ABSI01000005_gene1046 9.52e-61 208.0 COG4225@1|root,COG4225@2|Bacteria 2|Bacteria S unsaturated chondroitin disaccharide hydrolase activity - - - - - - - - - - - - DUF4861,Glyco_hydro_88 k59_976252_1 1165841.SULAR_02003 3.57e-63 216.0 COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,42M8F@68525|delta/epsilon subdivisions,2YNQF@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P COG0474 Cation transport ATPase - - 3.6.3.8 ko:K01537 - - - - ko00000,ko01000 3.A.3.2 - - Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3,Na_H_Exchanger k59_1655742_1 870187.Thini_4121 1.17e-19 95.5 COG3866@1|root,COG3866@2|Bacteria,1MUT3@1224|Proteobacteria,1RT2J@1236|Gammaproteobacteria 1236|Gammaproteobacteria G Pectate lyase pelZ - - - - - - - - - - - Beta_helix k59_468650_1 247633.GP2143_10012 8.41e-21 96.3 COG2211@1|root,COG2211@2|Bacteria,1MVUM@1224|Proteobacteria,1RP5J@1236|Gammaproteobacteria 1236|Gammaproteobacteria G COG2211 Na melibiose symporter and related transporters - - - ko:K03292 - - - - ko00000 2.A.2 - - MFS_2 k59_581796_1 1229909.NSED_06780 3.15e-65 218.0 COG1331@1|root,arCOG02007@2157|Archaea,41SHZ@651137|Thaumarchaeota 651137|Thaumarchaeota O Protein of unknown function, DUF255 - - - ko:K06888 - - - - ko00000 - - - Thioredox_DsbH k59_694724_1 264198.Reut_B5568 2.12e-62 202.0 COG5285@1|root,COG5285@2|Bacteria,1R5SE@1224|Proteobacteria,2VX7E@28216|Betaproteobacteria,1KI7V@119060|Burkholderiaceae 28216|Betaproteobacteria Q Phytanoyl-CoA dioxygenase (PhyH) - - 1.14.11.18 ko:K00477 ko04146,map04146 - - - ko00000,ko00001,ko01000 - - - PhyH k59_694724_2 340099.Teth39_1674 4.48e-83 260.0 COG1995@1|root,COG1995@2|Bacteria,1TQGT@1239|Firmicutes,24A12@186801|Clostridia,42FJX@68295|Thermoanaerobacterales 186801|Clostridia C Belongs to the PdxA family pdxA - 1.1.1.262,1.1.1.408,1.1.1.409 ko:K00097,ko:K22024 ko00750,ko01100,map00750,map01100 M00124 R05681,R05837,R07406 RC00089,RC00675,RC01475 ko00000,ko00001,ko00002,ko01000 - - - PdxA k59_1089988_1 1158756.AQXQ01000005_gene182 3.11e-16 83.6 COG0501@1|root,COG0501@2|Bacteria,1MVU4@1224|Proteobacteria,1RPJ5@1236|Gammaproteobacteria,1WWWM@135613|Chromatiales 135613|Chromatiales O PFAM peptidase M48 Ste24p - - - - - - - - - - - - Peptidase_M48 k59_1034798_1 395494.Galf_0474 1.43e-45 166.0 COG0457@1|root,COG0457@2|Bacteria,1MYB8@1224|Proteobacteria,2VI6C@28216|Betaproteobacteria,44VNS@713636|Nitrosomonadales 28216|Betaproteobacteria H Tetratricopeptide repeats - - - - - - - - - - - - TPR_16,TPR_19,TPR_8 k59_74166_1 563192.HMPREF0179_03605 2.68e-56 181.0 COG0290@1|root,COG0290@2|Bacteria,1RDD2@1224|Proteobacteria,42RHA@68525|delta/epsilon subdivisions,2WNQW@28221|Deltaproteobacteria,2M933@213115|Desulfovibrionales 28221|Deltaproteobacteria J IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins infC GO:0003674,GO:0003676,GO:0003723,GO:0003743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006413,GO:0006518,GO:0006807,GO:0006996,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016043,GO:0019538,GO:0022411,GO:0032790,GO:0032984,GO:0032988,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903008 - ko:K02520 - - - - ko00000,ko03012,ko03029 - - - IF3_C,IF3_N k59_242586_1 1163617.SCD_n01883 4.07e-33 127.0 COG1148@1|root,COG1908@1|root,COG1148@2|Bacteria,COG1908@2|Bacteria,1MWAG@1224|Proteobacteria,2WEVG@28216|Betaproteobacteria 28216|Betaproteobacteria C Methyl-viologen-reducing hydrogenase, delta subunit - - - ko:K16886 - - - - ko00000 - - - Fer4,FlpD,Pyr_redox_2 k59_242586_2 1123393.KB891317_gene2468 2.89e-29 115.0 COG1148@1|root,COG1148@2|Bacteria,1Q0ZF@1224|Proteobacteria,2VUBQ@28216|Betaproteobacteria,1KSSF@119069|Hydrogenophilales 119069|Hydrogenophilales C HI0933-like protein - - - - - - - - - - - - FAD_oxidored k59_1428877_1 443143.GM18_1338 2.51e-06 52.0 COG2843@1|root,COG2843@2|Bacteria 2|Bacteria M Bacterial capsule synthesis protein PGA_cap capA - - ko:K07282 - - - - ko00000 - - - PGA_cap k59_1428877_2 1033802.SSPSH_000622 6.48e-28 112.0 COG3087@1|root,COG3087@2|Bacteria,1MYFG@1224|Proteobacteria,1SD3J@1236|Gammaproteobacteria 1236|Gammaproteobacteria D Cell division protein ftsN - - ko:K03591 - - - - ko00000,ko03036 - - - SPOR k59_1428877_3 1232683.ADIMK_0794 9.38e-16 76.3 COG0018@1|root,COG0018@2|Bacteria,1MU4J@1224|Proteobacteria,1RPRC@1236|Gammaproteobacteria,464F2@72275|Alteromonadaceae 1236|Gammaproteobacteria J Arginyl-tRNA synthetase argS GO:0003674,GO:0003824,GO:0004812,GO:0004814,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006420,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.19 ko:K01887 ko00970,map00970 M00359,M00360 R03646 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d k59_865109_1 1265313.HRUBRA_01432 5.28e-33 138.0 COG1629@1|root,COG4771@2|Bacteria,1MWKN@1224|Proteobacteria,1SJX0@1236|Gammaproteobacteria,1J8GZ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P COG1629 Outer membrane receptor proteins, mostly Fe transport - - - - - - - - - - - - Plug,TonB_dep_Rec k59_356627_1 592026.GCWU0000282_002111 1.7e-05 54.3 COG4753@1|root,COG4977@1|root,COG4753@2|Bacteria,COG4977@2|Bacteria,1TSK4@1239|Firmicutes,24DXH@186801|Clostridia 186801|Clostridia T response regulator receiver - - - - - - - - - - - - HTH_18,HTH_AraC,Response_reg k59_1598621_1 469610.HMPREF0189_01111 5.97e-15 75.5 28HXV@1|root,2Z83C@2|Bacteria,1PJBP@1224|Proteobacteria,2VZV5@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_1598621_2 521000.PROVRETT_05509 7.41e-19 86.7 2AXQF@1|root,31PR8@2|Bacteria,1RKX8@1224|Proteobacteria,1S6JS@1236|Gammaproteobacteria,3Z9RC@586|Providencia 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_1655801_1 1108849.XP_002568960.1 1.82e-26 112.0 COG0726@1|root,2S2CW@2759|Eukaryota,39Z6D@33154|Opisthokonta,3NX9B@4751|Fungi,3QMPP@4890|Ascomycota,20C6E@147545|Eurotiomycetes,3S7UX@5042|Eurotiales 4751|Fungi O chitin deacetylase - - 3.5.1.41 ko:K01452 ko00520,ko01100,map00520,map01100 - R02333 RC00166,RC00300 ko00000,ko00001,ko01000 - - - Chitin_bind_1,Polysacc_deac_1 k59_1711675_1 1452718.JBOY01000024_gene350 1.11e-29 117.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria 1236|Gammaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K03296 - - - - ko00000 2.A.6.2 - - ACR_tran k59_1711675_2 1452718.JBOY01000024_gene349 3.44e-24 101.0 COG0845@1|root,COG0845@2|Bacteria,1MU78@1224|Proteobacteria,1RPI1@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family lmxE - - ko:K03585,ko:K07799,ko:K19586,ko:K19595 ko01501,ko01503,ko02020,map01501,map01503,map02020 M00646,M00647,M00648,M00699,M00718,M00767,M00768,M00769 - - ko00000,ko00001,ko00002,ko01504,ko02000,ko03036 2.A.6.2,2.A.6.2.25,2.A.6.2.34,2.A.6.2.47,8.A.1,8.A.1.6 - - Biotin_lipoyl_2,HlyD_D23 k59_865142_1 2002.JOEQ01000004_gene2914 1.14e-26 114.0 COG3866@1|root,COG3866@2|Bacteria,2GJEJ@201174|Actinobacteria,4EG85@85012|Streptosporangiales 201174|Actinobacteria G Amb_all pel - 4.2.2.2 ko:K01728 ko00040,ko02024,map00040,map02024 - R02361,R06240 RC00049,RC00705 ko00000,ko00001,ko01000 - - - Pec_lyase_C k59_976326_1 156889.Mmc1_2685 2.15e-21 98.2 COG0457@1|root,COG2114@1|root,COG3899@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG3899@2|Bacteria,1MUDT@1224|Proteobacteria,2TQVN@28211|Alphaproteobacteria 28211|Alphaproteobacteria T Adenylate and Guanylate cyclase catalytic domain - - 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 - - - AAA_16,DZR,Guanylate_cyc,TPR_12 k59_1768194_2 177437.HRM2_19130 1.99e-41 144.0 2E1BF@1|root,32WRB@2|Bacteria,1NAPP@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_468719_1 1229909.NSED_05655 1.83e-27 100.0 arCOG08662@1|root,arCOG08662@2157|Archaea 1229909.NSED_05655|- - - - - - - - - - - - - - - - k59_468719_2 436308.Nmar_0979 1.58e-60 196.0 COG1405@1|root,arCOG01981@2157|Archaea,41SXZ@651137|Thaumarchaeota 651137|Thaumarchaeota K Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB) - - - ko:K03124 ko03022,ko05169,ko05203,map03022,map05169,map05203 - - - ko00000,ko00001,ko03021 - - - TFIIB k59_1203498_1 1229909.NSED_00040 5.78e-108 321.0 COG0457@1|root,arCOG03032@2157|Archaea,41T0V@651137|Thaumarchaeota 651137|Thaumarchaeota S Tetratricopeptide repeat - - - - - - - - - - - - TPR_1 k59_1486518_1 987059.RBXJA2T_03101 1.18e-107 321.0 COG0547@1|root,COG0547@2|Bacteria,1MUPV@1224|Proteobacteria,2VH7F@28216|Betaproteobacteria,1KJ9I@119065|unclassified Burkholderiales 28216|Betaproteobacteria F Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) trpD GO:0000162,GO:0003674,GO:0003824,GO:0004048,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.18 ko:K00766 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R01073 RC00440 ko00000,ko00001,ko00002,ko01000 - - - Glycos_trans_3N,Glycos_transf_3 k59_865163_1 398720.MED217_13099 8.95e-46 168.0 COG0457@1|root,COG4249@1|root,COG0457@2|Bacteria,COG4249@2|Bacteria,4NS5V@976|Bacteroidetes 976|Bacteroidetes S TPR repeat - - - - - - - - - - - - Peptidase_C14,TPR_1,TPR_16,TPR_2,TPR_8 k59_1655834_1 1382356.JQMP01000003_gene1669 1.37e-10 67.4 COG1011@1|root,COG1011@2|Bacteria,2G73G@200795|Chloroflexi,27YDM@189775|Thermomicrobia 189775|Thermomicrobia S Haloacid dehalogenase-like hydrolase - - 3.1.3.102,3.1.3.104 ko:K20862 ko00740,ko01100,ko01110,map00740,map01100,map01110 M00125 R00548,R07280 RC00017 ko00000,ko00001,ko00002,ko01000 - - - HAD_2 k59_1655834_2 269800.Tfu_0269 2.25e-38 143.0 COG0018@1|root,COG0018@2|Bacteria,2GKQ3@201174|Actinobacteria,4EHMU@85012|Streptosporangiales 201174|Actinobacteria J Arginyl tRNA synthetase N terminal dom argS - 6.1.1.19 ko:K01887 ko00970,map00970 M00359,M00360 R03646 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d k59_751175_1 335543.Sfum_2691 8.36e-60 197.0 COG0240@1|root,COG0240@2|Bacteria,1MUU3@1224|Proteobacteria,42NQB@68525|delta/epsilon subdivisions,2WIWW@28221|Deltaproteobacteria,2MQCG@213462|Syntrophobacterales 28221|Deltaproteobacteria I NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus gpsA - 1.1.1.94 ko:K00057 ko00564,ko01110,map00564,map01110 - R00842,R00844 RC00029 ko00000,ko00001,ko01000 - - - NAD_Gly3P_dh_C,NAD_Gly3P_dh_N k59_1373345_2 502025.Hoch_1404 5.27e-91 313.0 COG0745@1|root,COG1352@1|root,COG2201@1|root,COG2202@1|root,COG2433@1|root,COG5002@1|root,COG0745@2|Bacteria,COG1352@2|Bacteria,COG2201@2|Bacteria,COG2202@2|Bacteria,COG2433@2|Bacteria,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,42NK9@68525|delta/epsilon subdivisions,2WMCQ@28221|Deltaproteobacteria 28221|Deltaproteobacteria T Response regulator receiver - - 2.1.1.80,3.1.1.61 ko:K13924 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko02022,ko02035 - - - CheB_methylest,CheR,CheR_N,GAF_2,HATPase_c,HisKA,PAS_10,PAS_3,PAS_4,PAS_9,Response_reg k59_524694_2 272844.PAB1605 2.68e-39 146.0 COG0367@1|root,arCOG00071@2157|Archaea,2XV5E@28890|Euryarchaeota,243QK@183968|Thermococci 183968|Thermococci E Glutamine amidotransferase domain - - 6.3.5.4 ko:K01953 ko00250,ko01100,ko01110,map00250,map01100,map01110 - R00578 RC00010 ko00000,ko00001,ko01000,ko01002 - - - Asn_synthase,GATase_7 k59_1373350_1 330214.NIDE1103 3.97e-108 318.0 COG0115@1|root,COG0115@2|Bacteria,3J0BM@40117|Nitrospirae 40117|Nitrospirae E Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family ilvE - 2.6.1.42 ko:K00826 ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00036,M00119,M00570 R01090,R01214,R02199,R10991 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_4 k59_186922_2 1266909.AUAG01000018_gene293 4.69e-09 57.0 COG1418@1|root,COG1418@2|Bacteria,1MZUS@1224|Proteobacteria,1S5FK@1236|Gammaproteobacteria,1WYFS@135613|Chromatiales 135613|Chromatiales S mRNA catabolic process - - - - - - - - - - - - - k59_808297_1 1122137.AQXF01000006_gene910 1.77e-103 311.0 COG0745@1|root,COG2199@1|root,COG0745@2|Bacteria,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria,2TQQM@28211|Alphaproteobacteria 28211|Alphaproteobacteria T response regulator containing a CheY-like receiver domain and a GGDEF domain pleD GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0042802,GO:0044424,GO:0044464 2.7.7.65 ko:K02488 ko02020,ko04112,map02020,map04112 M00511 R08057 - ko00000,ko00001,ko00002,ko01000,ko02022 - - - GGDEF,Response_reg k59_920788_1 1085623.GNIT_3056 3.12e-54 190.0 COG3590@1|root,COG3590@2|Bacteria,1MVNQ@1224|Proteobacteria,1RNNA@1236|Gammaproteobacteria,464DA@72275|Alteromonadaceae 1236|Gammaproteobacteria O Peptidase, M13 pepO - 3.4.24.71 ko:K01415,ko:K07386 - - - - ko00000,ko01000,ko01002,ko04147 - - - Peptidase_M13,Peptidase_M13_N k59_1373390_1 247633.GP2143_07934 6.25e-94 279.0 COG0175@1|root,COG0175@2|Bacteria,1MXUR@1224|Proteobacteria,1RNC5@1236|Gammaproteobacteria,1J5C2@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria EH COG0175 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase) FAD synthetase and related enzymes cysH - 1.8.4.10,1.8.4.8 ko:K00390 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00176 R02021 RC00007,RC02862 ko00000,ko00001,ko00002,ko01000 - - - PAPS_reduct k59_1259557_1 713587.THITH_12035 2.27e-06 53.9 COG5557@1|root,COG5557@2|Bacteria,1MXP7@1224|Proteobacteria,1RS7Z@1236|Gammaproteobacteria,1WX2A@135613|Chromatiales 135613|Chromatiales C PFAM Polysulphide reductase, NrfD - - - ko:K00185 - - - - ko00000 5.A.3 - - NrfD k59_1034903_1 938709.AUSH02000016_gene855 6.49e-12 64.3 COG1611@1|root,COG1611@2|Bacteria,4NF20@976|Bacteroidetes 976|Bacteroidetes S Belongs to the LOG family fmt2 - 3.2.2.10 ko:K06966 ko00230,ko00240,map00230,map00240 - R00182,R00510 RC00063,RC00318 ko00000,ko00001,ko01000 - - - Lysine_decarbox k59_1034903_2 1137281.D778_00991 8.91e-46 167.0 COG0308@1|root,COG0308@2|Bacteria,4NEJR@976|Bacteroidetes,1HYMW@117743|Flavobacteriia 976|Bacteroidetes E aminopeptidase N - - - - - - - - - - - - Peptidase_M1 k59_1259560_1 1265313.HRUBRA_01505 1.05e-143 433.0 COG0188@1|root,COG0188@2|Bacteria,1MURI@1224|Proteobacteria,1RMTC@1236|Gammaproteobacteria,1J4FT@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule parC GO:0000819,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006265,GO:0006276,GO:0006725,GO:0006807,GO:0006996,GO:0007049,GO:0007059,GO:0007062,GO:0008150,GO:0008152,GO:0009330,GO:0009987,GO:0016020,GO:0016043,GO:0019897,GO:0019898,GO:0022402,GO:0030541,GO:0032991,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0046483,GO:0051276,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:0098813,GO:1901360,GO:1901363 - ko:K02621 - - - - ko00000,ko01000,ko02048,ko03032,ko03036 - - - DNA_gyraseA_C,DNA_topoisoIV k59_865219_1 710686.Mycsm_05383 3.74e-21 90.1 COG2188@1|root,COG2188@2|Bacteria,2IAW7@201174|Actinobacteria,235M7@1762|Mycobacteriaceae 201174|Actinobacteria K transcriptional - - - - - - - - - - - - GntR,UTRA k59_865219_2 911239.CF149_12803 1.18e-18 85.5 COG0583@1|root,COG0583@2|Bacteria,1MUWX@1224|Proteobacteria,1RMVV@1236|Gammaproteobacteria 1236|Gammaproteobacteria K transcriptional regulator - - - ko:K17737 - - - - ko00000,ko03000 - - - HTH_1,LysR_substrate k59_1146599_1 365044.Pnap_2377 1.9e-43 161.0 COG0642@1|root,COG0642@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,2VGZQ@28216|Betaproteobacteria,4AA9F@80864|Comamonadaceae 28216|Betaproteobacteria T Histidine kinase - - - - - - - - - - - - HATPase_c,HisKA,Hpt,Response_reg k59_412292_1 485913.Krac_0884 8.56e-34 135.0 COG2909@1|root,COG2909@2|Bacteria 2|Bacteria K trisaccharide binding - - - ko:K03556 - - - - ko00000,ko03000 - - - AAA_16,GerE,NACHT,TPR_12 k59_1598727_1 436308.Nmar_0848 1.23e-93 285.0 COG1171@1|root,arCOG01431@2157|Archaea,41SCU@651137|Thaumarchaeota 651137|Thaumarchaeota E Pyridoxal-phosphate dependent enzyme - - 4.3.1.19 ko:K01754 ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230 M00570 R00220,R00996 RC00418,RC02600 ko00000,ko00001,ko00002,ko01000 - - - PALP k59_1429836_1 1041826.FCOL_00975 2.92e-09 60.5 COG0477@1|root,COG2814@2|Bacteria,4NFRE@976|Bacteroidetes,1HXWF@117743|Flavobacteriia,2NSSW@237|Flavobacterium 976|Bacteroidetes EGP MFS transporter - - - - - - - - - - - - MFS_1,MFS_3 k59_1429836_2 1168065.DOK_12216 3.54e-54 178.0 COG3224@1|root,COG3224@2|Bacteria,1QUU7@1224|Proteobacteria,1S1S3@1236|Gammaproteobacteria,1J74M@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S protein conserved in bacteria - - - ko:K09932 - - - - ko00000 - - - ABM k59_921718_1 411154.GFO_2796 4.58e-18 78.2 2AFHA@1|root,315HT@2|Bacteria,4NQ5F@976|Bacteroidetes,1I2SM@117743|Flavobacteriia 976|Bacteroidetes S S23 ribosomal protein - - - - - - - - - - - - 23S_rRNA_IVP k59_921718_2 1392490.JHZX01000001_gene3118 1.2e-77 241.0 28IST@1|root,2Z8RX@2|Bacteria,4NHVR@976|Bacteroidetes,1HWK1@117743|Flavobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_301034_1 1380358.JADJ01000018_gene2592 5.96e-151 429.0 COG3386@1|root,COG3386@2|Bacteria,1MXVD@1224|Proteobacteria,1RZMF@1236|Gammaproteobacteria 1236|Gammaproteobacteria G gluconolactonase - - - - - - - - - - - - SGL k59_695632_1 742725.HMPREF9450_00812 1.01e-38 145.0 COG1940@1|root,COG1940@2|Bacteria,4NHG5@976|Bacteroidetes,2FQJC@200643|Bacteroidia 976|Bacteroidetes GK ROK family - - 2.7.1.2 ko:K00845 ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200 M00001,M00549 R00299,R01600,R01786 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - ROK k59_1774447_1 102129.Lepto7375DRAFT_4110 2.74e-06 49.3 COG1502@1|root,COG1502@2|Bacteria,1G01I@1117|Cyanobacteria,1H79E@1150|Oscillatoriales 1117|Cyanobacteria I TIGRFAM Competence protein ComEA, helix-hairpin-helix comA - - - - - - - - - - - HHH_3,PLDc_2 k59_1774447_2 926569.ANT_30950 2.16e-42 155.0 COG0419@1|root,COG0433@1|root,COG0419@2|Bacteria,COG0433@2|Bacteria,2G87W@200795|Chloroflexi 200795|Chloroflexi L AAA-like domain - - - - - - - - - - - - - k59_873905_1 448385.sce7105 6.97e-25 102.0 COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,42MSR@68525|delta/epsilon subdivisions,2WIXG@28221|Deltaproteobacteria,2YUF5@29|Myxococcales 28221|Deltaproteobacteria I Belongs to the thiolase family bamN - 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N k59_250981_1 1121441.AUCX01000002_gene2750 4.32e-137 407.0 COG0559@1|root,COG0559@2|Bacteria,1MVND@1224|Proteobacteria,42MY2@68525|delta/epsilon subdivisions,2WR5C@28221|Deltaproteobacteria,2MATK@213115|Desulfovibrionales 28221|Deltaproteobacteria E Branched-chain amino acid transport system / permease component - - - - - - - - - - - - BPD_transp_2 k59_83127_1 1117647.M5M_13565 1.47e-130 387.0 COG0811@1|root,COG0811@2|Bacteria,1MX5J@1224|Proteobacteria,1RMSA@1236|Gammaproteobacteria,1J4VD@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria U MotA TolQ ExbB proton channel family protein - - - ko:K03561 - - - - ko00000,ko02000 1.A.30.2.1 - - MotA_ExbB k59_983380_1 1396858.Q666_12485 4.05e-59 192.0 COG1028@1|root,COG1028@2|Bacteria,1MWBC@1224|Proteobacteria,1RNNV@1236|Gammaproteobacteria,46407@72275|Alteromonadaceae 1236|Gammaproteobacteria IQ COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) yciK GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0008150,GO:0008152,GO:0009056,GO:0016491,GO:0044464,GO:0055114,GO:0071704,GO:1901575 - - - - - - - - - - adh_short k59_475620_1 1121374.KB891575_gene802 6.13e-65 203.0 COG1917@1|root,COG1917@2|Bacteria,1N3S2@1224|Proteobacteria 1224|Proteobacteria S Aspartyl/Asparaginyl beta-hydroxylase - - - - - - - - - - - - Asp_Arg_Hydrox k59_475620_2 1380394.JADL01000020_gene1825 1.65e-28 114.0 COG0685@1|root,COG0685@2|Bacteria,1MXTZ@1224|Proteobacteria,2TWKE@28211|Alphaproteobacteria,2JRIW@204441|Rhodospirillales 28211|Alphaproteobacteria E Methylenetetrahydrofolate reductase - - - - - - - - - - - - MTHFR k59_814738_1 1394178.AWOO02000054_gene8001 7.57e-29 119.0 COG0028@1|root,COG0028@2|Bacteria,2GN3X@201174|Actinobacteria 201174|Actinobacteria EH Belongs to the TPP enzyme family - - 4.1.1.7 ko:K01576 ko00627,ko01120,map00627,map01120 - R01764,R02672 RC00595 ko00000,ko00001,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_1551762_2 1437425.CSEC_0290 9.26e-30 114.0 2FF9B@1|root,34775@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_1551762_3 1121878.AUGL01000006_gene538 1.28e-06 52.8 COG2227@1|root,COG2227@2|Bacteria,1MU89@1224|Proteobacteria,1RMX7@1236|Gammaproteobacteria 1236|Gammaproteobacteria H O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway - - 2.1.1.222,2.1.1.64 ko:K00568 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00117 R04988,R05614,R08769,R08781 RC00003,RC00392,RC01895 ko00000,ko00001,ko00002,ko01000 - - - Methyltransf_11,Methyltransf_23 k59_1720529_1 404589.Anae109_1875 3.45e-89 276.0 COG0065@1|root,COG0065@2|Bacteria,1MVYR@1224|Proteobacteria,42M5D@68525|delta/epsilon subdivisions,2WJ59@28221|Deltaproteobacteria,2YU3W@29|Myxococcales 28221|Deltaproteobacteria H Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate leuC - 4.2.1.33,4.2.1.35 ko:K01703 ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230 M00432,M00535 R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170 RC00497,RC00976,RC00977,RC01041,RC01046,RC03072 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase k59_138704_1 1125863.JAFN01000001_gene2321 1.1e-55 177.0 COG0778@1|root,COG0778@2|Bacteria,1RBBW@1224|Proteobacteria,42QWC@68525|delta/epsilon subdivisions,2WMVU@28221|Deltaproteobacteria 28221|Deltaproteobacteria C PFAM Nitroreductase - - - - - - - - - - - - Nitroreductase k59_138704_2 1125863.JAFN01000001_gene2914 1e-28 110.0 COG0708@1|root,COG0708@2|Bacteria,1MVII@1224|Proteobacteria,42NY7@68525|delta/epsilon subdivisions,2WIXK@28221|Deltaproteobacteria 28221|Deltaproteobacteria L exodeoxyribonuclease III - - 3.1.11.2 ko:K01142 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - Exo_endo_phos k59_83149_1 1301098.PKB_4218 1.77e-86 269.0 COG1611@1|root,COG1611@2|Bacteria,1MVQJ@1224|Proteobacteria,1RQHX@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Rossmann fold nucleotide-binding protein ygdH GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016787,GO:0016798,GO:0016799,GO:0044424,GO:0044444,GO:0044464,GO:0047405 3.2.2.10 ko:K06966 ko00230,ko00240,map00230,map00240 - R00182,R00510 RC00063,RC00318 ko00000,ko00001,ko01000 - - - DUF3412,DUF4478,Lysine_decarbox k59_814740_1 1415778.JQMM01000001_gene591 2.35e-175 500.0 COG0843@1|root,COG0843@2|Bacteria,1MU7S@1224|Proteobacteria,1RPC3@1236|Gammaproteobacteria,1J4DV@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B ctaD - 1.9.3.1 ko:K02274 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6 - iJN746.PP_0104 COX1 k59_251001_1 1114964.L485_12625 2.36e-116 341.0 COG5527@1|root,COG5527@2|Bacteria,1R6VS@1224|Proteobacteria,2TV08@28211|Alphaproteobacteria,2K197@204457|Sphingomonadales 204457|Sphingomonadales L Replication initiation protein - - - - - - - - - - - - Rep_3 k59_1154584_1 575540.Isop_0867 3.76e-12 71.2 COG2010@1|root,COG2010@2|Bacteria,2IZC1@203682|Planctomycetes 203682|Planctomycetes C cytochrome C - - - - - - - - - - - - Cytochrom_C,Cytochrome_CBB3 k59_1435967_1 450851.PHZ_c2411 2.58e-120 362.0 COG0145@1|root,COG0145@2|Bacteria,1MU2Y@1224|Proteobacteria,2TRBN@28211|Alphaproteobacteria 28211|Alphaproteobacteria EQ N-methylhydantoinase A acetone carboxylase, beta subunit - - - - - - - - - - - - Hydant_A_N,Hydantoinase_A k59_420141_1 1517416.IDAT_03570 1.9e-63 220.0 COG1629@1|root,COG1629@2|Bacteria,COG4771@2|Bacteria,1MU9K@1224|Proteobacteria,1RMTG@1236|Gammaproteobacteria,2QEY1@267893|Idiomarinaceae 1236|Gammaproteobacteria P TonB dependent receptor - - - - - - - - - - - - Plug,TonB_dep_Rec k59_1551795_1 2045.KR76_07185 1.3e-34 139.0 COG3276@1|root,COG3276@2|Bacteria,2GKF9@201174|Actinobacteria,4DP4G@85009|Propionibacteriales 201174|Actinobacteria J Elongation factor SelB, winged helix selB - - ko:K03833 - - - - ko00000,ko03012 - - - GTP_EFTU,GTP_EFTU_D2,SelB-wing_2,SelB-wing_3 k59_1323532_1 390989.JOEG01000005_gene1793 6.52e-36 132.0 COG1974@1|root,COG1974@2|Bacteria,2GMBN@201174|Actinobacteria,4D8KV@85008|Micromonosporales 201174|Actinobacteria K Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair lexA GO:0000976,GO:0001067,GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0006355,GO:0006950,GO:0006974,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032991,GO:0032993,GO:0033554,GO:0042221,GO:0043565,GO:0044212,GO:0044464,GO:0045892,GO:0045934,GO:0046677,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051716,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2001141 3.4.21.88 ko:K01356 - M00729 - - ko00000,ko00002,ko01000,ko01002,ko03400 - - - LexA_DNA_bind,Peptidase_S24 k59_1323532_2 596320.NEIFL0001_1671 6.44e-47 164.0 COG0253@1|root,COG0253@2|Bacteria,1MWDH@1224|Proteobacteria,2VI0C@28216|Betaproteobacteria,2KQ16@206351|Neisseriales 206351|Neisseriales E Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan dapF - 5.1.1.7 ko:K01778 ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00527 R02735 RC00302 ko00000,ko00001,ko00002,ko01000 - - - DAP_epimerase k59_1323532_3 932678.THERU_01235 2.86e-08 58.9 COG0324@1|root,COG0324@2|Bacteria,2G3QA@200783|Aquificae 200783|Aquificae J Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) miaA GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016765,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0052381,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.5.1.75 ko:K00791 ko00908,ko01100,ko01110,map00908,map01100,map01110 - R01122 RC02820 ko00000,ko00001,ko01000,ko01006,ko03016 - - - IPPT k59_25996_1 1122137.AQXF01000003_gene2323 1.95e-129 372.0 COG0752@1|root,COG0752@2|Bacteria,1MVCJ@1224|Proteobacteria,2TS2N@28211|Alphaproteobacteria 28211|Alphaproteobacteria J glycyl-tRNA synthetase alpha subunit glyQ - 6.1.1.14 ko:K01878 ko00970,map00970 M00360 R03654 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_2e k59_1551807_1 717605.Theco_0807 4.99e-84 261.0 2C4CB@1|root,2Z7XX@2|Bacteria,1V8K4@1239|Firmicutes,4HZ7X@91061|Bacilli,273JK@186822|Paenibacillaceae 91061|Bacilli L EcoRII C terminal - - - - - - - - - - - - - k59_645283_1 1042156.CXIVA_09270 2.55e-19 93.6 COG2812@1|root,COG2812@2|Bacteria,1TPS9@1239|Firmicutes,247J7@186801|Clostridia,36DBN@31979|Clostridiaceae 186801|Clostridia L DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity dnaX - 2.7.7.7 ko:K02343 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_delta2,DNA_pol3_gamma3 k59_1097569_2 436308.Nmar_1052 5.22e-62 192.0 arCOG08740@1|root,arCOG08740@2157|Archaea,41T52@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1097569_3 1229909.NSED_06160 3.51e-90 266.0 COG1321@1|root,arCOG02100@2157|Archaea,41SQ9@651137|Thaumarchaeota 651137|Thaumarchaeota K iron dependent repressor - - - - - - - - - - - - Fe_dep_repr_C,Fe_dep_repress k59_1323540_1 316407.85675129 4.22e-48 162.0 COG4638@1|root,COG4638@2|Bacteria,1MWXW@1224|Proteobacteria,1RYN7@1236|Gammaproteobacteria,3XQJJ@561|Escherichia 1236|Gammaproteobacteria P Belongs to the bacterial ring-hydroxylating dioxygenase alpha subunit family. CntA subfamily yeaW GO:0003674,GO:0005488,GO:0005515,GO:0008150,GO:0009987,GO:0016043,GO:0022607,GO:0042802,GO:0043933,GO:0044085,GO:0048037,GO:0051259,GO:0051260,GO:0051536,GO:0051537,GO:0051540,GO:0065003,GO:0070206,GO:0070207,GO:0071840 1.14.13.239,1.14.15.7 ko:K00499,ko:K22443 ko00260,map00260 - R07409 RC00087 ko00000,ko00001,ko01000 - - - Rieske,Ring_hydroxyl_A k59_1323540_2 155864.EDL933_2769 1.2e-74 237.0 COG1292@1|root,COG1292@2|Bacteria,1MV0K@1224|Proteobacteria,1RP3E@1236|Gammaproteobacteria,3XQSW@561|Escherichia 1236|Gammaproteobacteria M nitrogen compound transport yeaV GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0016020,GO:0044464,GO:0051179,GO:0051234,GO:0071705,GO:0071944 - ko:K03451,ko:K05245 - - - - ko00000,ko02000 2.A.15,2.A.15.2 - iB21_1397.B21_00043,iECBD_1354.ECBD_3575,iECB_1328.ECB_00044,iECD_1391.ECD_00044,iEcSMS35_1347.EcSMS35_1387 BCCT k59_475651_1 272560.BPSS0099 1.28e-20 90.1 COG3157@1|root,COG3157@2|Bacteria,1RC6P@1224|Proteobacteria,2VQKT@28216|Betaproteobacteria,1K6SP@119060|Burkholderiaceae 28216|Betaproteobacteria S type VI secretion system effector - - - ko:K11903 ko02025,ko03070,map02025,map03070 M00334 - - ko00000,ko00001,ko00002,ko02044 - - - T6SS_HCP k59_475651_2 1532557.JL37_20660 1.41e-87 275.0 COG3517@1|root,COG3517@2|Bacteria,1MU5C@1224|Proteobacteria,2VKCP@28216|Betaproteobacteria,3T6RP@506|Alcaligenaceae 28216|Betaproteobacteria S protein conserved in bacteria impC - - ko:K11900 ko02025,map02025 M00334 - - ko00000,ko00001,ko00002,ko02044 3.A.23.1 - - VipB k59_365610_1 1229909.NSED_03430 7.24e-66 216.0 COG0155@1|root,arCOG02055@2157|Archaea,41S5Q@651137|Thaumarchaeota 651137|Thaumarchaeota C Sulfite reductase - - 1.8.7.1 ko:K00392 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00176 R00859,R03600 RC00065 ko00000,ko00001,ko00002,ko01000 - - - NIR_SIR,NIR_SIR_ferr k59_1266424_1 2340.JV46_04600 1.03e-16 78.6 28NKC@1|root,2ZBM7@2|Bacteria,1MWMY@1224|Proteobacteria,1S4WY@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_26017_1 1123234.AUKI01000020_gene681 7.88e-13 69.3 COG0531@1|root,COG0531@2|Bacteria,4NH7J@976|Bacteroidetes,1HY25@117743|Flavobacteriia 976|Bacteroidetes E amino acid - - - - - - - - - - - - AA_permease_2 k59_531258_1 236097.ADG881_2243 9.87e-30 119.0 COG0208@1|root,COG0208@2|Bacteria,1R4T3@1224|Proteobacteria,1S1Y5@1236|Gammaproteobacteria 1236|Gammaproteobacteria F P-aminobenzoate N-oxygenase AurF - - - - - - - - - - - - AurF k59_1266428_1 1545915.JROG01000004_gene2565 2.88e-36 134.0 COG1414@1|root,COG1414@2|Bacteria,1QRZN@1224|Proteobacteria,2TU6N@28211|Alphaproteobacteria,2K7AP@204457|Sphingomonadales 204457|Sphingomonadales K Transcriptional regulator - - - ko:K05818 - - - - ko00000,ko03000 - - - HTH_IclR,IclR k59_1212031_2 298386.PBPRB1779 4.15e-15 70.1 COG1278@1|root,COG1278@2|Bacteria,1N6Q5@1224|Proteobacteria,1SCA7@1236|Gammaproteobacteria,1XYBB@135623|Vibrionales 135623|Vibrionales K COG1278 Cold shock proteins - - - ko:K03704 - - - - ko00000,ko03000 - - - CSD k59_531263_1 1122137.AQXF01000001_gene2963 2.93e-87 280.0 COG0642@1|root,COG2205@2|Bacteria,1MVY8@1224|Proteobacteria,2TS5B@28211|Alphaproteobacteria 28211|Alphaproteobacteria T Histidine kinase divL GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - - - - - - - - - - HATPase_c,HisKA,PAS_7,PAS_8 k59_1607873_1 436308.Nmar_1632 1.36e-78 236.0 COG0550@1|root,arCOG01527@2157|Archaea,41TBA@651137|Thaumarchaeota 651137|Thaumarchaeota L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone - - 5.99.1.2 ko:K03168 - - - - ko00000,ko01000,ko03032,ko03400 - - - - k59_26033_1 1122194.AUHU01000003_gene2322 9.23e-17 74.3 COG0853@1|root,COG0853@2|Bacteria,1RI1B@1224|Proteobacteria,1S66E@1236|Gammaproteobacteria,46727@72275|Alteromonadaceae 1236|Gammaproteobacteria H Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine panD GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0010467,GO:0016485,GO:0016540,GO:0019538,GO:0043170,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0051604,GO:0071704,GO:1901564 4.1.1.11 ko:K01579 ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110 M00119 R00489 RC00299 ko00000,ko00001,ko00002,ko01000 - - iECP_1309.ECP_0139,iYL1228.KPN_00139 Asp_decarbox k59_26033_2 997350.HMPREF9129_0940 2.4e-10 63.9 COG0414@1|root,COG0414@2|Bacteria,1TP7A@1239|Firmicutes,248AN@186801|Clostridia,22G2D@1570339|Peptoniphilaceae 186801|Clostridia H Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate panC - 6.3.2.1 ko:K01918 ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110 M00119 R02473 RC00096,RC00141 ko00000,ko00001,ko00002,ko01000 - - - Pantoate_ligase k59_1382091_1 864069.MicloDRAFT_00045150 1.67e-06 49.7 COG0500@1|root,COG0640@1|root,COG0640@2|Bacteria,COG2226@2|Bacteria,1NFSV@1224|Proteobacteria,2TSMV@28211|Alphaproteobacteria,1JTRT@119045|Methylobacteriaceae 28211|Alphaproteobacteria KQ PFAM regulatory protein ArsR arsR - - - - - - - - - - - HTH_20,HTH_5,Methyltransf_11,Methyltransf_31 k59_308843_1 1209072.ALBT01000023_gene4083 1.1e-30 117.0 COG3017@1|root,COG3017@2|Bacteria,1N02T@1224|Proteobacteria,1S91E@1236|Gammaproteobacteria,1FHDX@10|Cellvibrio 1236|Gammaproteobacteria M Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein lolB GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0006807,GO:0008104,GO:0008150,GO:0008152,GO:0008289,GO:0009279,GO:0010876,GO:0016020,GO:0019538,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0033036,GO:0033218,GO:0034613,GO:0042157,GO:0042277,GO:0043170,GO:0044238,GO:0044462,GO:0044464,GO:0044872,GO:0044873,GO:0044874,GO:0051179,GO:0051641,GO:0051668,GO:0070727,GO:0071704,GO:0071723,GO:0071944,GO:0072657,GO:1901564 - ko:K02494 - - - - ko00000 - - - LolB k59_138778_1 1122137.AQXF01000006_gene814 2.1e-72 238.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2TQS3@28211|Alphaproteobacteria 28211|Alphaproteobacteria T Diguanylate cyclase - - - - - - - - - - - - EAL,GGDEF k59_138778_2 1122137.AQXF01000006_gene813 7.44e-27 109.0 2C8CD@1|root,2Z9AD@2|Bacteria,1N17D@1224|Proteobacteria,2U86Q@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_590367_1 395494.Galf_1572 4.92e-75 236.0 COG0205@1|root,COG0205@2|Bacteria,1MVN3@1224|Proteobacteria,2VK7J@28216|Betaproteobacteria 28216|Betaproteobacteria H Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions pfkA - 2.7.1.11,2.7.1.90 ko:K00850,ko:K21071 ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230 M00001,M00345 R00756,R00764,R02073,R03236,R03237,R03238,R03239,R04779 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000,ko01009,ko03019 - - - PFK k59_1324430_1 1038862.KB893807_gene2096 2.05e-80 251.0 COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2TR7Q@28211|Alphaproteobacteria,3JTSN@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria C CoA-transferase family III - - - - - - - - - - - - CoA_transf_3 k59_366946_1 1397528.Q671_06795 1.75e-108 325.0 COG2041@1|root,COG2041@2|Bacteria,1MX9E@1224|Proteobacteria,1RP2M@1236|Gammaproteobacteria,1XICY@135619|Oceanospirillales 135619|Oceanospirillales S Mo-co oxidoreductase dimerisation domain - - - - - - - - - - - - Mo-co_dimer,Oxidored_molyb k59_984347_1 1282362.AEAC466_11915 2.81e-46 167.0 COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,2TRYI@28211|Alphaproteobacteria,2KFKP@204458|Caulobacterales 204458|Caulobacterales C PFAM FAD linked oxidase domain protein - - - - - - - - - - - - FAD-oxidase_C,FAD_binding_4 k59_1553198_1 1297742.A176_02081 7.14e-46 160.0 COG3488@1|root,COG3488@2|Bacteria,1MXUW@1224|Proteobacteria,42YAW@68525|delta/epsilon subdivisions,2WTPQ@28221|Deltaproteobacteria,2YU9D@29|Myxococcales 28221|Deltaproteobacteria C Di-haem oxidoreductase, putative peroxidase - - - - - - - - - - - - DHOR k59_1553198_2 477228.YO5_17955 0.000128 52.0 COG0642@1|root,COG4191@1|root,COG2205@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,1T24C@1236|Gammaproteobacteria,1YZXS@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria T COG0642 Signal transduction histidine kinase - - - - - - - - - - - - HATPase_c,HisKA,PAS_3,Response_reg,dCache_1 k59_646209_1 868595.Desca_2372 6.92e-30 120.0 COG2206@1|root,COG2206@2|Bacteria,1TQIM@1239|Firmicutes,248S5@186801|Clostridia,260W0@186807|Peptococcaceae 186801|Clostridia T PFAM Metal-dependent phosphohydrolase, HD - - - - - - - - - - - - HD,HD_5 k59_140010_1 1415778.JQMM01000001_gene64 2.89e-105 317.0 COG0498@1|root,COG0498@2|Bacteria,1MUWQ@1224|Proteobacteria,1RQ0H@1236|Gammaproteobacteria,1J5MK@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E COG0498 Threonine synthase thrC GO:0003674,GO:0003824,GO:0004795,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006566,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009088,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016838,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.2.3.1 ko:K01733 ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230 M00018 R01466,R05086 RC00017,RC00526 ko00000,ko00001,ko00002,ko01000 - - iLF82_1304.LF82_2261,iNRG857_1313.NRG857_00025 PALP,Thr_synth_N k59_1155557_1 879212.DespoDRAFT_03758 2.3e-11 70.1 COG3852@1|root,COG3852@2|Bacteria,1NTTH@1224|Proteobacteria,42MC9@68525|delta/epsilon subdivisions,2WIYS@28221|Deltaproteobacteria,2MHU3@213118|Desulfobacterales 28221|Deltaproteobacteria T PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - 2.7.13.3 ko:K07709 ko02020,map02020 M00499 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA,PAS_9 k59_1155557_2 1150469.RSPPHO_00624 6.65e-75 243.0 COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,2TS7G@28211|Alphaproteobacteria,2JPZX@204441|Rhodospirillales 204441|Rhodospirillales S COG0488 ATPase components of ABC transporters with duplicated ATPase domains - - - - - - - - - - - - ABC_tran,ABC_tran_Xtn k59_591549_1 1254432.SCE1572_49280 6.82e-84 271.0 COG0437@1|root,COG3302@1|root,COG0437@2|Bacteria,COG3302@2|Bacteria,1MU1B@1224|Proteobacteria,42M97@68525|delta/epsilon subdivisions,2WJB4@28221|Deltaproteobacteria,2Z1ZF@29|Myxococcales 28221|Deltaproteobacteria C 4Fe-4S dicluster domain hmcB GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - - - - - - - - - - Fer4_11,Fer4_4,Fer4_7 k59_532051_1 1122137.AQXF01000004_gene1794 4.63e-100 302.0 COG0766@1|root,COG0766@2|Bacteria,1MUH7@1224|Proteobacteria,2TRPH@28211|Alphaproteobacteria 28211|Alphaproteobacteria M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine murA - 2.5.1.7 ko:K00790 ko00520,ko00550,ko01100,map00520,map00550,map01100 - R00660 RC00350 ko00000,ko00001,ko01000,ko01011 - - - EPSP_synthase k59_815513_2 330214.NIDE3871 1.07e-28 107.0 COG5592@1|root,COG5592@2|Bacteria 2|Bacteria I hemerythrin HHE cation binding domain - - - - - - - - - - - - Hemerythrin,Phasin_2 k59_1045003_1 330214.NIDE0325 1.18e-87 271.0 COG1236@1|root,COG1236@2|Bacteria,3J0FD@40117|Nitrospirae 40117|Nitrospirae J Beta-Casp domain - - - ko:K07576 - - - - ko00000 - - - Beta-Casp,Lactamase_B,RMMBL k59_928682_1 323848.Nmul_A1770 3.01e-90 282.0 COG1217@1|root,COG1217@2|Bacteria,1MV5Q@1224|Proteobacteria,2VH2W@28216|Betaproteobacteria,372H8@32003|Nitrosomonadales 28216|Betaproteobacteria T protein synthesis factor, GTP-binding typA - - ko:K06207 - - - - ko00000 - - - EFG_C,GTP_EFTU,GTP_EFTU_D2 k59_1045006_1 391616.OA238_c40150 3.39e-141 408.0 COG0517@1|root,COG0517@2|Bacteria,1MXI6@1224|Proteobacteria,2TS6X@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Transposase - - - - - - - - - - - - Y2_Tnp,Zn_Tnp_IS91 k59_252292_1 203122.Sde_0100 5.1e-75 240.0 COG3608@1|root,COG3608@2|Bacteria,1MUAA@1224|Proteobacteria,1RNQQ@1236|Gammaproteobacteria,464NX@72275|Alteromonadaceae 1236|Gammaproteobacteria S Succinylglutamate desuccinylase / Aspartoacylase family - - - ko:K06987 - - - - ko00000 - - - AstE_AspA k59_1777858_1 744979.R2A130_0217 1.06e-78 241.0 COG0047@1|root,COG0047@2|Bacteria,1MU4Y@1224|Proteobacteria,2TS67@28211|Alphaproteobacteria 28211|Alphaproteobacteria F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL purQ GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 6.3.5.3 ko:K01952 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04463 RC00010,RC01160 ko00000,ko00001,ko00002,ko01000 - - - GATase_5 k59_761861_1 472759.Nhal_2778 1.66e-93 276.0 COG0764@1|root,COG0764@2|Bacteria,1MWV8@1224|Proteobacteria,1RP6W@1236|Gammaproteobacteria,1WX8R@135613|Chromatiales 135613|Chromatiales I Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length fabA - 4.2.1.59,5.3.3.14 ko:K01716 ko00061,ko01100,ko01212,map00061,map01100,map01212 M00083 R04428,R04535,R04537,R04544,R04568,R04954,R04965,R07639 RC00831,RC01078,RC01095 ko00000,ko00001,ko00002,ko01000,ko01004 - - - FabA k59_1048554_2 1121015.N789_08730 2.45e-61 198.0 COG0258@1|root,COG0258@2|Bacteria,1RAAR@1224|Proteobacteria,1RN1S@1236|Gammaproteobacteria,1X448@135614|Xanthomonadales 135614|Xanthomonadales L Exodeoxyribonuclease IX exo - - - - - - - - - - - 5_3_exonuc,5_3_exonuc_N k59_931704_1 1411123.JQNH01000001_gene676 9.64e-87 268.0 COG0683@1|root,COG0683@2|Bacteria,1MV5T@1224|Proteobacteria,2TQZC@28211|Alphaproteobacteria 28211|Alphaproteobacteria E COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component - - - ko:K01999 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - Peripla_BP_6 k59_819088_1 243365.CV_1920 3.58e-06 48.1 COG1741@1|root,COG1741@2|Bacteria,1MWIP@1224|Proteobacteria,2VHGK@28216|Betaproteobacteria,2KQT9@206351|Neisseriales 206351|Neisseriales S Belongs to the pirin family - - - ko:K06911 - - - - ko00000 - - - Pirin,Pirin_C k59_931714_1 314225.ELI_03175 4.96e-95 292.0 COG0366@1|root,COG0366@2|Bacteria,1MVKX@1224|Proteobacteria,2TRS3@28211|Alphaproteobacteria,2K1CG@204457|Sphingomonadales 204457|Sphingomonadales G Alpha-amylase domain - - 3.2.1.20 ko:K01187 ko00052,ko00500,ko01100,map00052,map00500,map01100 - R00028,R00801,R00802,R06087,R06088 RC00028,RC00049,RC00077 ko00000,ko00001,ko01000 - GH31 - Alpha-amylase,DUF3459 k59_1387629_1 1229909.NSED_03295 5.15e-58 184.0 arCOG08653@1|root,arCOG08653@2157|Archaea,41T9H@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1612642_1 1265502.KB905945_gene654 6.03e-56 182.0 COG1028@1|root,COG1028@2|Bacteria,1MUFX@1224|Proteobacteria,2VMB3@28216|Betaproteobacteria,4ACE3@80864|Comamonadaceae 28216|Betaproteobacteria IQ PFAM Short-chain dehydrogenase reductase SDR tsaC GO:0003674,GO:0003824,GO:0006725,GO:0008150,GO:0008152,GO:0009987,GO:0010130,GO:0016043,GO:0016491,GO:0016614,GO:0016616,GO:0018913,GO:0018915,GO:0022607,GO:0042537,GO:0043933,GO:0044085,GO:0044237,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:1901360 1.1.1.100 ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 k59_1612642_2 85643.Tmz1t_1758 1.08e-43 154.0 COG3146@1|root,COG3146@2|Bacteria,1MU35@1224|Proteobacteria,2VH0Z@28216|Betaproteobacteria,2KUC4@206389|Rhodocyclales 206389|Rhodocyclales S protein conserved in bacteria - - - ko:K09919 - - - - ko00000 - - - FemAB_like k59_1101647_1 1480694.DC28_14620 6.04e-162 473.0 COG0187@1|root,COG0187@2|Bacteria,2J6PT@203691|Spirochaetes 203691|Spirochaetes L DNA topoisomerase parE - - ko:K02622 - - - - ko00000,ko01000,ko02048,ko03032,ko03036 - - - DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim k59_479572_1 766499.C357_19763 6.42e-93 283.0 COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2TR7Q@28211|Alphaproteobacteria 28211|Alphaproteobacteria C L-carnitine dehydratase bile acid-inducible protein F - - 2.8.3.16 ko:K07749 - - - - ko00000,ko01000 - - - CoA_transf_3 k59_1777879_1 1121912.AUHD01000014_gene1065 1.36e-103 310.0 COG1228@1|root,COG1228@2|Bacteria,4NE6C@976|Bacteroidetes,1HYME@117743|Flavobacteriia 976|Bacteroidetes Q Belongs to the metallo-dependent hydrolases superfamily. HutI family hutI - 3.5.2.7 ko:K01468 ko00340,ko01100,map00340,map01100 M00045 R02288 RC00683 ko00000,ko00001,ko00002,ko01000 - - - Amidohydro_1,Amidohydro_3 k59_1440049_1 436308.Nmar_0099 9.43e-125 376.0 COG2511@1|root,arCOG01719@2157|Archaea,41S8Q@651137|Thaumarchaeota 651137|Thaumarchaeota J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate gatE - 6.3.5.7 ko:K03330 ko00970,ko01100,map00970,map01100 - R03905 RC00010 ko00000,ko00001,ko01000 - - - GAD,GatB_N,GatB_Yqey k59_1101653_1 1206729.BAFZ01000120_gene3219 1.05e-19 92.4 COG0477@1|root,COG2814@2|Bacteria,2GKY3@201174|Actinobacteria,4FUZS@85025|Nocardiaceae 201174|Actinobacteria EGP Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 k59_424015_1 1134474.O59_004030 1.87e-83 262.0 COG1140@1|root,COG1140@2|Bacteria,1MW9Q@1224|Proteobacteria,1RNMJ@1236|Gammaproteobacteria 1236|Gammaproteobacteria C nitrate reductase beta subunit narH GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006082,GO:0006091,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008940,GO:0009055,GO:0009061,GO:0009325,GO:0009898,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0016661,GO:0019645,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0031235,GO:0032991,GO:0033554,GO:0042126,GO:0043436,GO:0044237,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0044799,GO:0045333,GO:0048037,GO:0050896,GO:0051536,GO:0051538,GO:0051539,GO:0051540,GO:0051716,GO:0055114,GO:0070469,GO:0070470,GO:0071704,GO:0071944,GO:0098552,GO:0098562,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1990204,GO:2001057 1.7.5.1 ko:K00371 ko00910,ko01120,ko02020,map00910,map01120,map02020 M00529,M00530,M00804 R00798,R01106,R09497 RC02812 ko00000,ko00001,ko00002,ko01000 5.A.3.1 - iEcE24377_1341.EcE24377A_1376,iEcolC_1368.EcolC_2189 Fer4_11,Nitr_red_bet_C k59_819119_1 483219.LILAB_17840 2.85e-113 337.0 COG1219@1|root,COG1219@2|Bacteria,1MVQK@1224|Proteobacteria,42MWJ@68525|delta/epsilon subdivisions,2WJ8Q@28221|Deltaproteobacteria,2YUHC@29|Myxococcales 28221|Deltaproteobacteria O ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP clpX GO:0000166,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005524,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030163,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0044238,GO:0051301,GO:0070011,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575 - ko:K03544 ko04112,map04112 - - - ko00000,ko00001,ko03110 - - - AAA_2,ClpB_D2-small,zf-C4_ClpX k59_256434_1 436308.Nmar_0865 2.35e-103 311.0 COG0436@1|root,arCOG01130@2157|Archaea 2157|Archaea E PFAM Aminotransferase class I and II - - 2.6.1.1 ko:K00812 ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230 - R00355,R00694,R00734,R00896,R02433,R02619,R05052 RC00006 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_1_2 k59_1101660_1 998674.ATTE01000001_gene1918 1.24e-50 179.0 COG0855@1|root,COG0855@2|Bacteria,1MUM3@1224|Proteobacteria,1RNRX@1236|Gammaproteobacteria,45ZT3@72273|Thiotrichales 72273|Thiotrichales P Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) ppk - 2.7.4.1 ko:K00937 ko00190,ko03018,map00190,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - PP_kinase,PP_kinase_C,PP_kinase_N k59_931737_1 1136417.AZWE01000045_gene3176 7.82e-56 192.0 COG5297@1|root,COG5297@2|Bacteria,2GK92@201174|Actinobacteria,4D9YE@85008|Micromonosporales 201174|Actinobacteria G Belongs to the glycosyl hydrolase family 6 - - 3.2.1.91 ko:K19668 ko00500,ko01100,ko02020,map00500,map01100,map02020 - R02886,R11308 RC00799 ko00000,ko00001,ko01000 - GH6 - CBM_2,Glyco_hydro_6 k59_761888_1 404380.Gbem_1401 2.75e-28 111.0 2C8XG@1|root,2Z7PK@2|Bacteria,1RA5I@1224|Proteobacteria,42QRD@68525|delta/epsilon subdivisions,2WMYW@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Protein of unknown function (DUF4197) - - - - - - - - - - - - DUF4197 k59_761888_2 1158292.JPOE01000005_gene608 7.6e-30 120.0 COG0842@1|root,COG0842@2|Bacteria,1N55T@1224|Proteobacteria,2VJ7R@28216|Betaproteobacteria 28216|Betaproteobacteria V Transport permease protein nodJ - - ko:K09694 ko02010,map02010 M00252 - - ko00000,ko00001,ko00002,ko02000 3.A.1.102 - - ABC2_membrane k59_761888_3 909613.UO65_5153 2.84e-50 177.0 COG1131@1|root,COG1131@2|Bacteria,2GIY8@201174|Actinobacteria,4DYWA@85010|Pseudonocardiales 201174|Actinobacteria V ABC transporter - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_1612678_1 1205680.CAKO01000037_gene1244 5.51e-91 283.0 COG0146@1|root,COG0146@2|Bacteria,1QU46@1224|Proteobacteria,2TVYU@28211|Alphaproteobacteria,2JQP4@204441|Rhodospirillales 204441|Rhodospirillales EQ Hydantoinase B/oxoprolinase - - - - - - - - - - - - Hydantoinase_B k59_1270652_1 1123242.JH636435_gene1111 9.77e-86 263.0 COG4260@1|root,COG4260@2|Bacteria,2IYIR@203682|Planctomycetes 203682|Planctomycetes S virion core protein (lumpy skin disease virus) - - - - - - - - - - - - Band_7_1,DUF4339 k59_1270652_2 1496688.ER33_15965 7.87e-13 70.9 COG3809@1|root,COG3809@2|Bacteria 2|Bacteria S Transcription factor zinc-finger - - - ko:K09981 - - - - ko00000 - - - zf-TFIIB k59_1725313_1 187272.Mlg_0452 1.92e-106 342.0 COG0086@1|root,COG0086@2|Bacteria,1MU3M@1224|Proteobacteria,1RPYH@1236|Gammaproteobacteria,1WVVI@135613|Chromatiales 135613|Chromatiales K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoC - 2.7.7.6 ko:K03046 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5 k59_1048656_1 1162668.LFE_1339 8.49e-77 242.0 COG2801@1|root,COG2801@2|Bacteria 2|Bacteria L transposition - - - - - - - - - - - - rve k59_595885_1 314275.MADE_1001145 1.32e-66 218.0 COG4146@1|root,COG4146@2|Bacteria,1MXWV@1224|Proteobacteria,1RR4S@1236|Gammaproteobacteria,463ZX@72275|Alteromonadaceae 1236|Gammaproteobacteria S Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family sglT - - ko:K03307 - - - - ko00000 2.A.21 - - SSF k59_1101691_1 436308.Nmar_0289 2.16e-105 308.0 COG0461@1|root,arCOG00029@2157|Archaea,41SJU@651137|Thaumarchaeota 651137|Thaumarchaeota F Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) pyrE - 2.4.2.10 ko:K00762 ko00240,ko01100,map00240,map01100 M00051 R01870 RC00611 ko00000,ko00001,ko00002,ko01000 - - - Pribosyltran k59_424058_1 1229909.NSED_01465 3.03e-79 246.0 COG0598@1|root,arCOG02265@2157|Archaea,41SZC@651137|Thaumarchaeota 651137|Thaumarchaeota P Mg2 transporter protein - - - ko:K03284 - - - - ko00000,ko02000 1.A.35.1,1.A.35.3 - - CorA k59_1725326_1 314287.GB2207_09126 2.91e-74 235.0 COG0306@1|root,COG0306@2|Bacteria,1MVXK@1224|Proteobacteria,1RP0Q@1236|Gammaproteobacteria,1J4ST@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P COG0306 Phosphate sulphate permeases pitA GO:0003674,GO:0005215,GO:0005315,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006817,GO:0006820,GO:0008150,GO:0015291,GO:0015318,GO:0015698,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0035435,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098656,GO:0098660,GO:0098661 - ko:K03306 - - - - ko00000 2.A.20 - - PHO4 k59_931781_1 679926.Mpet_1130 1.44e-52 176.0 COG0668@1|root,arCOG01569@2157|Archaea,2XVK0@28890|Euryarchaeota,2N9S8@224756|Methanomicrobia 224756|Methanomicrobia M MscS Mechanosensitive ion channel - - - - - - - - - - - - MS_channel k59_761926_1 1278307.KB906974_gene1742 2.68e-10 66.2 COG1808@1|root,COG1808@2|Bacteria,1NMS3@1224|Proteobacteria,1RRTC@1236|Gammaproteobacteria 1236|Gammaproteobacteria I Domain of unknown function (DUF389) - - - - - - - - - - - - DUF389 k59_1101701_1 1122137.AQXF01000006_gene720 7.46e-60 203.0 COG1785@1|root,COG1785@2|Bacteria,1MXI2@1224|Proteobacteria,2TTUZ@28211|Alphaproteobacteria 28211|Alphaproteobacteria P Belongs to the alkaline phosphatase family phoA - 3.1.3.1 ko:K01077 ko00730,ko00790,ko01100,ko02020,map00730,map00790,map01100,map02020 M00126 R02135,R04620 RC00017 ko00000,ko00001,ko00002,ko00537,ko01000,ko04147 - - - Alk_phosphatase k59_1440109_1 1492922.GY26_10550 1.08e-73 238.0 COG0077@1|root,COG1605@1|root,COG0077@2|Bacteria,COG1605@2|Bacteria,1MU60@1224|Proteobacteria,1RNRD@1236|Gammaproteobacteria,1J4I4@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E chorismate mutase pheA - 4.2.1.51,5.4.99.5 ko:K14170 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00024,M00025 R00691,R01373,R01715 RC00360,RC03116 ko00000,ko00001,ko00002,ko01000 - - - ACT,CM_2,PDT k59_1777941_1 317013.NY99_16480 7.42e-93 290.0 COG0445@1|root,COG0445@2|Bacteria,1MU6F@1224|Proteobacteria,1RMM1@1236|Gammaproteobacteria,1X36F@135614|Xanthomonadales 135614|Xanthomonadales D NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 gidA GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901363 - ko:K03495 - - R08701 RC00053,RC00209,RC00870 ko00000,ko03016,ko03036 - - - GIDA,GIDA_assoc k59_371235_1 1131812.JQMS01000001_gene2729 3.15e-27 120.0 COG2304@1|root,COG3391@1|root,COG5184@1|root,COG2304@2|Bacteria,COG3391@2|Bacteria,COG5184@2|Bacteria,4PKD0@976|Bacteroidetes,1HWKJ@117743|Flavobacteriia,2NSCM@237|Flavobacterium 976|Bacteroidetes O oxidoreductase activity - - - - - - - - - - - - CHU_C,HYR,LRR_adjacent k59_987563_2 768671.ThimaDRAFT_2563 2.87e-59 189.0 COG0693@1|root,COG0693@2|Bacteria,1N7T2@1224|Proteobacteria,1RSBI@1236|Gammaproteobacteria,1WY2E@135613|Chromatiales 135613|Chromatiales S TIGRFAM DJ-1 family protein - - 3.5.1.124 ko:K03152 - - - - ko00000,ko01000,ko01002 - - - DJ-1_PfpI k59_1612711_1 589865.DaAHT2_0992 4.84e-35 140.0 COG0784@1|root,COG4191@1|root,COG0784@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42M1R@68525|delta/epsilon subdivisions,2WK3J@28221|Deltaproteobacteria,2MI5F@213118|Desulfobacterales 28221|Deltaproteobacteria T histidine kinase A domain protein - - - - - - - - - - - - HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg k59_1612711_2 247633.GP2143_13131 1.34e-16 89.0 COG0477@1|root,COG2814@2|Bacteria,1MVSC@1224|Proteobacteria,1S029@1236|Gammaproteobacteria,1J786@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria EGP COG0477 Permeases of the major facilitator superfamily - - - - - - - - - - - - MFS_1 k59_819215_2 158500.BV97_03272 3.26e-21 91.7 COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2TQR1@28211|Alphaproteobacteria,2JZVD@204457|Sphingomonadales 204457|Sphingomonadales C belongs to the aldehyde dehydrogenase family - - 1.2.1.3 ko:K00128 ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130 M00135 R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146 RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_1387760_1 1229909.NSED_08760 5.3e-54 172.0 COG0784@1|root,arCOG02391@2157|Archaea 2157|Archaea T response regulator, receiver - - - ko:K03413 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko02022,ko02035 - - - Response_reg k59_1387760_2 1229909.NSED_06250 0.0002 40.8 arCOG10955@1|root,arCOG10955@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_314500_1 344747.PM8797T_00899 1.69e-118 358.0 COG0702@1|root,COG0702@2|Bacteria,2IYQV@203682|Planctomycetes 203682|Planctomycetes GM PFAM NAD-dependent epimerase dehydratase - - - - - - - - - - - - DUF2867,NAD_binding_10 k59_314505_1 631454.N177_3223 1.59e-65 211.0 COG0583@1|root,COG0583@2|Bacteria,1MW16@1224|Proteobacteria,2TRIG@28211|Alphaproteobacteria,1JP23@119043|Rhodobiaceae 28211|Alphaproteobacteria K LysR substrate binding domain MA20_14610 - - - - - - - - - - - HTH_1,LysR_substrate k59_1389084_1 1144310.PMI07_005859 3.24e-16 77.8 COG0745@1|root,COG0745@2|Bacteria,1MVCB@1224|Proteobacteria,2TVHH@28211|Alphaproteobacteria,4BAQ7@82115|Rhizobiaceae 28211|Alphaproteobacteria T Transcriptional regulatory protein, C terminal MA20_06295 - - ko:K02483 - - - - ko00000,ko02022 - - - Response_reg,Trans_reg_C k59_257786_2 436308.Nmar_1417 1.01e-61 191.0 COG0494@1|root,arCOG01078@2157|Archaea,41SPS@651137|Thaumarchaeota 651137|Thaumarchaeota L NUDIX domain - - - - - - - - - - - - NUDIX k59_1726255_1 396588.Tgr7_2757 7.51e-75 238.0 COG0403@1|root,COG0403@2|Bacteria,1MVC1@1224|Proteobacteria,1RPGZ@1236|Gammaproteobacteria,1WWD2@135613|Chromatiales 135613|Chromatiales E The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor gcvPA - 1.4.4.2 ko:K00282 ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200 - R01221,R03425 RC00022,RC00929,RC02834,RC02880 ko00000,ko00001,ko01000 - - - GDC-P k59_710401_1 1437882.AZRU01000009_gene902 5.98e-62 214.0 COG1123@1|root,COG4239@1|root,COG4172@2|Bacteria,COG4239@2|Bacteria,1MU09@1224|Proteobacteria,1RMEI@1236|Gammaproteobacteria,1YFBM@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria P Belongs to the ABC transporter superfamily yejF GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006857,GO:0008144,GO:0008150,GO:0015399,GO:0015405,GO:0015833,GO:0015893,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0035672,GO:0036094,GO:0042221,GO:0042493,GO:0042623,GO:0042626,GO:0042884,GO:0042886,GO:0042891,GO:0043167,GO:0043168,GO:0043492,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - ko:K13896 ko02010,map02010 M00349 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5.21,3.A.1.5.24 - - ABC_tran,oligo_HPY k59_1328328_1 1121428.DESHY_160210___1 1.72e-33 125.0 COG2071@1|root,COG2071@2|Bacteria,1V1KC@1239|Firmicutes,24JCU@186801|Clostridia,261S6@186807|Peptococcaceae 186801|Clostridia S PFAM Peptidase C26 - - - ko:K07010 - - - - ko00000,ko01002 - - - Peptidase_C26 k59_144017_2 448385.sce7527 1.23e-104 315.0 COG4447@1|root,COG4447@2|Bacteria,1ND1J@1224|Proteobacteria,432XE@68525|delta/epsilon subdivisions,2WYHS@28221|Deltaproteobacteria,2YU0E@29|Myxococcales 28221|Deltaproteobacteria S protein related to plant photosystem II stability assembly factor - - - - - - - - - - - - - k59_932801_3 436308.Nmar_0238 2.51e-94 277.0 COG1146@1|root,arCOG04548@2157|Archaea,41SI0@651137|Thaumarchaeota 651137|Thaumarchaeota C PFAM 4Fe-4S dicluster domain - - - - - - - - - - - - Fer4 k59_932801_4 436308.Nmar_0237 3.85e-72 223.0 COG1976@1|root,arCOG04176@2157|Archaea,41SIP@651137|Thaumarchaeota 651137|Thaumarchaeota J Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex eif6 - - ko:K03264 ko03008,map03008 - - - ko00000,ko00001,ko03009,ko03012 - - - eIF-6 k59_1050088_1 161156.JQKW01000007_gene778 1.24e-09 62.8 COG0084@1|root,COG0084@2|Bacteria,2GH9G@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria L TatD related DNase - - - ko:K03424 - - - - ko00000,ko01000 - - - TatD_DNase k59_315846_1 1149133.ppKF707_5579 2.29e-22 89.7 COG1765@1|root,COG1765@2|Bacteria,1RCZW@1224|Proteobacteria,1S3XF@1236|Gammaproteobacteria,1YFYJ@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria O OsmC-like protein yhfA - - ko:K07397 - - - - ko00000 - - - OsmC k59_315846_2 1265490.JHVY01000011_gene662 3.73e-19 84.7 COG0664@1|root,COG0664@2|Bacteria,1MXID@1224|Proteobacteria,1RMIZ@1236|Gammaproteobacteria 1236|Gammaproteobacteria K COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases crp GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0007154,GO:0007584,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009605,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0009991,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0016070,GO:0017076,GO:0018130,GO:0019001,GO:0019219,GO:0019222,GO:0019438,GO:0030551,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0031667,GO:0031668,GO:0031669,GO:0031670,GO:0032553,GO:0032555,GO:0032561,GO:0032774,GO:0032991,GO:0032993,GO:0034641,GO:0034645,GO:0034654,GO:0035438,GO:0036094,GO:0042221,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0045013,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0045990,GO:0046483,GO:0046983,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0051716,GO:0060255,GO:0061984,GO:0061985,GO:0065007,GO:0070887,GO:0071496,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097367,GO:0097659,GO:0140110,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:2000112,GO:2000113,GO:2001141 - ko:K10914 ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111 - - - ko00000,ko00001,ko03000 - - - Crp,cNMP_binding k59_710424_1 1229909.NSED_09600 5.44e-174 493.0 COG0112@1|root,arCOG00070@2157|Archaea,41S7U@651137|Thaumarchaeota 651137|Thaumarchaeota E Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism glyA - 2.1.2.1 ko:K00600 ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523 M00140,M00141,M00346,M00532 R00945,R09099 RC00022,RC00112,RC01583,RC02958 ko00000,ko00001,ko00002,ko01000 - - - SHMT k59_880884_1 1168065.DOK_00460 2.96e-73 241.0 COG4257@1|root,COG4257@2|Bacteria,1R448@1224|Proteobacteria,1T0QH@1236|Gammaproteobacteria,1J7GQ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria V COG4257 Streptogramin lyase - - - - - - - - - - - - CarboxypepD_reg k59_597257_1 296591.Bpro_3995 2.68e-61 204.0 COG2244@1|root,COG2244@2|Bacteria,1MXWW@1224|Proteobacteria,2VNZP@28216|Betaproteobacteria 28216|Betaproteobacteria S Pfam Polysaccharide biosynthesis protein - - - - - - - - - - - - Polysacc_synt,Polysacc_synt_3 k59_200170_1 37919.EP51_14130 3.89e-44 155.0 COG0657@1|root,COG0657@2|Bacteria,2GKX2@201174|Actinobacteria,4FX64@85025|Nocardiaceae 201174|Actinobacteria I Esterase - - - ko:K01066 - - - - ko00000,ko01000 - - - Abhydrolase_3 k59_1559269_1 706587.Desti_2582 9.45e-177 507.0 COG0459@1|root,COG0459@2|Bacteria,1MURR@1224|Proteobacteria,42M52@68525|delta/epsilon subdivisions,2WIRK@28221|Deltaproteobacteria,2MRAR@213462|Syntrophobacterales 28221|Deltaproteobacteria O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions groL - - ko:K04077 ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 - - - Cpn60_TCP1 k59_1271593_1 2340.JV46_28430 3.05e-26 108.0 COG4651@1|root,COG4651@2|Bacteria,1QUQS@1224|Proteobacteria,1T21E@1236|Gammaproteobacteria,1J57I@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P Kef-type K transport kefC_1 - - - - - - - - - - - Na_H_Exchanger k59_762879_1 1125863.JAFN01000001_gene40 1.44e-86 265.0 COG0416@1|root,COG0416@2|Bacteria,1MVM3@1224|Proteobacteria,42NRV@68525|delta/epsilon subdivisions,2WIXX@28221|Deltaproteobacteria 28221|Deltaproteobacteria I Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA plsX - 2.3.1.15 ko:K03621 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R00851,R09380 RC00004,RC00039,RC00041 ko00000,ko00001,ko00002,ko01000,ko01004 - - - FA_synthesis k59_1668413_1 1163617.SCD_n02058 2.57e-16 81.3 COG2199@1|root,COG3159@1|root,COG3159@2|Bacteria,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria,2WEJC@28216|Betaproteobacteria 28216|Betaproteobacteria T Diguanylate cyclase - - 2.7.7.65 ko:K02488 ko02020,ko04112,map02020,map04112 M00511 R08057 - ko00000,ko00001,ko00002,ko01000,ko02022 - - - DUF484,GGDEF k59_1559273_1 1380600.AUYN01000007_gene3305 1.26e-52 168.0 COG1393@1|root,COG1393@2|Bacteria,4NSAW@976|Bacteroidetes,1I450@117743|Flavobacteriia 976|Bacteroidetes P Belongs to the ArsC family - - 1.20.4.1 ko:K00537 - - - - ko00000,ko01000 - - - ArsC k59_1559273_2 1137281.D778_01683 1.68e-109 323.0 COG0697@1|root,COG0697@2|Bacteria,4NGZ3@976|Bacteroidetes,1HYCJ@117743|Flavobacteriia 976|Bacteroidetes EG Permeases of the drug metabolite transporter (DMT) superfamily - - - - - - - - - - - - EamA k59_1389137_1 1232429.CBLL010000100_gene1125 0.000424 47.8 COG3401@1|root,COG3401@2|Bacteria,2GMCU@201174|Actinobacteria 201174|Actinobacteria M cellulose binding - - - - - - - - - - - - - k59_932831_1 335543.Sfum_0239 2.66e-14 73.9 COG3568@1|root,COG3568@2|Bacteria,1MVN7@1224|Proteobacteria,42T9X@68525|delta/epsilon subdivisions,2WP59@28221|Deltaproteobacteria,2MQNB@213462|Syntrophobacterales 28221|Deltaproteobacteria L Endonuclease/Exonuclease/phosphatase family - - - - - - - - - - - - Exo_endo_phos k59_89661_1 1443111.JASG01000004_gene1041 2.14e-30 114.0 COG4674@1|root,COG4674@2|Bacteria,1MUBR@1224|Proteobacteria,2TQVJ@28211|Alphaproteobacteria,3ZUWN@60136|Sulfitobacter 28211|Alphaproteobacteria S Branched-chain amino acid ATP-binding cassette transporter MA20_23055 - - ko:K11962 ko02010,map02010 M00323 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4.4,3.A.1.4.5 - - ABC_tran,BCA_ABC_TP_C k59_89661_2 391595.RLO149_c009520 1.96e-22 97.1 COG4177@1|root,COG4177@2|Bacteria,1MUPI@1224|Proteobacteria,2TTN2@28211|Alphaproteobacteria,2P21Z@2433|Roseobacter 28211|Alphaproteobacteria P Branched-chain amino acid transport system / permease component - - - ko:K11961 ko02010,map02010 M00323 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4.4,3.A.1.4.5 - - BPD_transp_2 k59_597280_1 279238.Saro_3035 8.54e-107 327.0 COG0457@1|root,COG0457@2|Bacteria,1MVMG@1224|Proteobacteria,2TSGE@28211|Alphaproteobacteria,2K04M@204457|Sphingomonadales 204457|Sphingomonadales S Sulfotransferase family - - - - - - - - - - - - Sulfotransfer_3,TPR_14,TPR_16,TPR_19,TPR_8 k59_32947_1 321332.CYB_2518 1.27e-58 192.0 COG3001@1|root,COG3001@2|Bacteria,1G040@1117|Cyanobacteria,1GZY8@1129|Synechococcus 1117|Cyanobacteria G COG3001 Fructosamine-3-kinase - GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0044237 - - - - - - - - - - Fructosamin_kin k59_762888_1 436308.Nmar_1581 1.4e-81 247.0 COG2266@1|root,arCOG01871@2157|Archaea,41SRI@651137|Thaumarchaeota 651137|Thaumarchaeota M MobA-like NTP transferase domain - - 2.7.7.62 ko:K19712 ko00860,ko01100,map00860,map01100 - R05222 RC00002 ko00000,ko00001,ko01000 - - - NTP_transf_3 k59_40341_1 1122137.AQXF01000001_gene3160 7.68e-51 166.0 COG0625@1|root,COG0625@2|Bacteria,1MXM4@1224|Proteobacteria,2TTXD@28211|Alphaproteobacteria 28211|Alphaproteobacteria O Glutathione S-transferase gst - 2.5.1.18 ko:K00799 ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418 - R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905 RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944 ko00000,ko00001,ko01000,ko02000 1.A.12.2.2,1.A.12.3.2 - - GST_C,GST_C_2,GST_C_3,GST_N_3 k59_40341_2 1177928.TH2_00145 3.58e-08 54.7 COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,1MU7B@1224|Proteobacteria,2TRHQ@28211|Alphaproteobacteria,2JPK2@204441|Rhodospirillales 204441|Rhodospirillales E glutamate synthase gltB - 1.4.1.13,1.4.1.14 ko:K00265 ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 - R00093,R00114,R00248 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - GATase_2,GXGXG,Glu_syn_central,Glu_synthase k59_431083_1 436308.Nmar_0173 2.06e-39 136.0 COG1028@1|root,arCOG01259@2157|Archaea,41SYZ@651137|Thaumarchaeota 651137|Thaumarchaeota I Enoyl-(Acyl carrier protein) reductase - - 1.1.1.100 ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 k59_1732581_1 523791.Kkor_0736 6.21e-73 238.0 COG4805@1|root,COG4805@2|Bacteria,1MUBX@1224|Proteobacteria,1RMT7@1236|Gammaproteobacteria,1XMZK@135619|Oceanospirillales 135619|Oceanospirillales S Bacterial protein of unknown function (DUF885) - - - - - - - - - - - - DUF885 k59_769307_1 1144305.PMI02_03671 2.65e-39 144.0 COG2015@1|root,COG2015@2|Bacteria,1MU82@1224|Proteobacteria,2U7UU@28211|Alphaproteobacteria,2K9ER@204457|Sphingomonadales 204457|Sphingomonadales Q Alkyl sulfatase dimerisation - - - - - - - - - - - - Alkyl_sulf_dimr,Lactamase_B k59_769307_2 13690.CP98_01847 2.09e-22 94.7 COG1063@1|root,COG1063@2|Bacteria,1NTHK@1224|Proteobacteria,2UQ2F@28211|Alphaproteobacteria,2KCXW@204457|Sphingomonadales 204457|Sphingomonadales E Alcohol dehydrogenase GroES-like domain - - - - - - - - - - - - ADH_N,ADH_zinc_N k59_486882_1 1254432.SCE1572_33210 3.2e-65 224.0 COG0417@1|root,COG0417@2|Bacteria,1MVY9@1224|Proteobacteria,42Q4K@68525|delta/epsilon subdivisions,2WKQ1@28221|Deltaproteobacteria,2Z1M7@29|Myxococcales 28221|Deltaproteobacteria L DNA polymerase type-B family polB - 2.7.7.7 ko:K02336 - - - - ko00000,ko01000,ko03400 - - - DNA_pol_B,DNA_pol_B_exo1,RNase_H_2 k59_541982_1 49964.Q94MS4_9CAUD 1.17e-104 328.0 4QCUF@10239|Viruses,4QV7U@35237|dsDNA viruses no RNA stage,4QQ89@28883|Caudovirales,4QNCY@10744|Podoviridae 10744|Podoviridae - - - - - - - - - - - - - - - k59_323549_1 1472716.KBK24_0120380 5.51e-08 58.9 COG2355@1|root,COG2355@2|Bacteria,1R7DN@1224|Proteobacteria,2W0DI@28216|Betaproteobacteria,1K4GB@119060|Burkholderiaceae 28216|Betaproteobacteria E Zn-dependent dipeptidase, microsomal dipeptidase - - - - - - - - - - - - - k59_541988_1 702113.PP1Y_AT11717 8.97e-79 249.0 COG0477@1|root,COG2814@2|Bacteria,1MVQQ@1224|Proteobacteria,2TRBF@28211|Alphaproteobacteria,2K261@204457|Sphingomonadales 204457|Sphingomonadales EGP Major Facilitator - - - - - - - - - - - - MFS_1 k59_888460_1 1530186.JQEY01000006_gene3316 6.86e-74 229.0 COG3576@1|root,COG3576@2|Bacteria,1MWG9@1224|Proteobacteria,2TSKK@28211|Alphaproteobacteria 28211|Alphaproteobacteria S flavin-nucleotide-binding protein structurally related to pyridoxine 5'-phosphate oxidase MA20_21430 - - ko:K07006 - - - - ko00000 - - - Putative_PNPOx k59_1674347_1 589873.EP13_11845 1.24e-65 215.0 COG0471@1|root,COG0471@2|Bacteria,1MUSA@1224|Proteobacteria,1RPU5@1236|Gammaproteobacteria,46411@72275|Alteromonadaceae 1236|Gammaproteobacteria P COG0471 Di- and tricarboxylate transporters sdcS - - ko:K14445 - - - - ko00000,ko02000 2.A.47.1 - - Na_sulph_symp k59_379958_1 477184.KYC_07216 3.74e-40 145.0 COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2VKDI@28216|Betaproteobacteria,3T2HK@506|Alcaligenaceae 28216|Betaproteobacteria S protein conserved in bacteria - - - - - - - - - - - - TctC k59_656963_1 1400524.KL370779_gene372 1.4e-66 223.0 COG3046@1|root,COG3046@2|Bacteria,1MUHX@1224|Proteobacteria,2TQP6@28211|Alphaproteobacteria,4BP8J@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria S PFAM FAD binding domain of DNA photolyase phrB GO:0000166,GO:0000719,GO:0003674,GO:0003824,GO:0003913,GO:0003914,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006290,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016829,GO:0016830,GO:0033554,GO:0034641,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0050896,GO:0051536,GO:0051539,GO:0051540,GO:0051716,GO:0071704,GO:0071949,GO:0090304,GO:0097159,GO:0140097,GO:1901265,GO:1901360,GO:1901363 - ko:K06876 - - - - ko00000 - - - DPRP,FAD_binding_7 k59_96101_1 761193.Runsl_4194 3.2e-51 170.0 COG0135@1|root,COG0135@2|Bacteria,4NK5D@976|Bacteroidetes,47NUD@768503|Cytophagia 976|Bacteroidetes E N-(5'phosphoribosyl)anthranilate (PRA) isomerase - - 5.3.1.24 ko:K01817 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R03509 RC00945 ko00000,ko00001,ko00002,ko01000 - - - PRAI k59_1732612_1 1332071.L581_4336 2.68e-14 74.7 COG1391@1|root,COG1391@2|Bacteria,1MU4I@1224|Proteobacteria,1RP9N@1236|Gammaproteobacteria,3ZZIS@613|Serratia 1236|Gammaproteobacteria OT Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell glnE GO:0000166,GO:0000287,GO:0000820,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006521,GO:0006541,GO:0006542,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0008882,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0010565,GO:0016053,GO:0016740,GO:0016772,GO:0016779,GO:0017076,GO:0019222,GO:0019752,GO:0030554,GO:0031323,GO:0032553,GO:0032555,GO:0032559,GO:0033238,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046872,GO:0050789,GO:0050794,GO:0051171,GO:0062012,GO:0065007,GO:0070566,GO:0071704,GO:0080090,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.7.42,2.7.7.89 ko:K00982 - - - - ko00000,ko01000 - - - GlnD_UR_UTase,GlnE k59_1732612_2 1286106.MPL1_01204 4.42e-118 345.0 COG0115@1|root,COG0115@2|Bacteria,1MVB0@1224|Proteobacteria,1RP6Z@1236|Gammaproteobacteria,4603P@72273|Thiotrichales 72273|Thiotrichales E Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family ilvE - 2.6.1.42 ko:K00826 ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00036,M00119,M00570 R01090,R01214,R02199,R10991 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_4 k59_266367_1 1122931.AUAE01000010_gene4464 7.4e-35 135.0 COG1453@1|root,COG1453@2|Bacteria,4NJU2@976|Bacteroidetes,2G2UD@200643|Bacteroidia,231JU@171551|Porphyromonadaceae 976|Bacteroidetes S Aldo/keto reductase family - - - ko:K07079 - - - - ko00000 - - - Aldo_ket_red,Fer4_17 k59_606263_1 330214.NIDE3268 8.53e-114 338.0 COG3005@1|root,COG3005@2|Bacteria 2|Bacteria C denitrification pathway - - - - - - - - - - - - Cytochrome_C554 k59_432159_1 640511.BC1002_6656 7.75e-37 142.0 COG0457@1|root,COG2114@1|root,COG3899@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG3899@2|Bacteria,1MUDT@1224|Proteobacteria,2VSSJ@28216|Betaproteobacteria,1K5FA@119060|Burkholderiaceae 28216|Betaproteobacteria T PFAM adenylyl cyclase class-3 4 guanylyl cyclase - - - - - - - - - - - - AAA_16,BTAD,Guanylate_cyc,SAM_1,TPR_12,Trans_reg_C k59_719410_1 189753.AXAS01000004_gene969 4.31e-38 137.0 COG2309@1|root,COG2309@2|Bacteria,1R4JS@1224|Proteobacteria,2TRJ7@28211|Alphaproteobacteria,3JUNZ@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria E COG2309 Leucyl aminopeptidase (aminopeptidase T) MA20_38180 - 1.13.11.9 ko:K18028 ko00760,ko01120,map00760,map01120 M00622 R09125 RC02430 ko00000,ko00001,ko00002,ko01000 - - - - k59_1169587_1 93220.LV28_12665 1.04e-52 179.0 COG0493@1|root,COG0493@2|Bacteria,1MU2H@1224|Proteobacteria,2VIHR@28216|Betaproteobacteria,1K273@119060|Burkholderiaceae 28216|Betaproteobacteria C glutamate synthase gltD - 1.4.1.13,1.4.1.14 ko:K00266 ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 - R00093,R00114,R00248 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - Fer4_20,Pyr_redox_2 k59_1169587_2 288000.BBta_4569 2.38e-05 48.1 COG0664@1|root,COG0664@2|Bacteria,1QW7C@1224|Proteobacteria,2TWR0@28211|Alphaproteobacteria,3K6MN@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria T Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - - - - - - - - - - cNMP_binding k59_1675601_1 1056820.KB900700_gene1084 1.65e-41 140.0 COG2080@1|root,COG2080@2|Bacteria,1RD8C@1224|Proteobacteria,1S3RP@1236|Gammaproteobacteria,2PNFX@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria C [2Fe-2S] binding domain - - 1.3.99.16 ko:K07302 - - - - ko00000,ko01000 - - - Fer2,Fer2_2 k59_1675601_2 1122137.AQXF01000003_gene2144 1.04e-17 83.2 COG1529@1|root,COG1529@2|Bacteria,1QTTJ@1224|Proteobacteria,2TQVK@28211|Alphaproteobacteria 28211|Alphaproteobacteria C COG1529 Aerobic-type carbon monoxide dehydrogenase large subunit CoxL CutL homologs MA20_34355 - 1.3.99.16 ko:K07303 - - - - ko00000,ko01000 - - - Ald_Xan_dh_C,Ald_Xan_dh_C2 k59_1225605_1 478749.BRYFOR_06086 3.68e-27 112.0 2FFDF@1|root,347B2@2|Bacteria,1VYJJ@1239|Firmicutes,256XH@186801|Clostridia 186801|Clostridia S Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - - k59_1675603_1 545264.KB898745_gene1259 3.48e-86 263.0 COG0136@1|root,COG0136@2|Bacteria,1MUHG@1224|Proteobacteria,1RNB6@1236|Gammaproteobacteria,1WWMZ@135613|Chromatiales 135613|Chromatiales E Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate asd - 1.2.1.11 ko:K00133 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00017,M00018,M00033,M00525,M00526,M00527 R02291 RC00684 ko00000,ko00001,ko00002,ko01000 - - - Semialdhyde_dh,Semialdhyde_dhC k59_1568190_1 316274.Haur_3928 6.53e-23 100.0 COG1477@1|root,COG1477@2|Bacteria,2G6WH@200795|Chloroflexi,375JB@32061|Chloroflexia 32061|Chloroflexia H Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein - - 2.7.1.180 ko:K03734 - - - - ko00000,ko01000 - - - ApbE k59_41335_1 1121479.AUBS01000001_gene3509 3.75e-145 423.0 COG0683@1|root,COG0683@2|Bacteria,1MWH7@1224|Proteobacteria,2TS8K@28211|Alphaproteobacteria 28211|Alphaproteobacteria E branched-chain amino acid - - - ko:K01999 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - Peripla_BP_6 k59_1733660_1 158500.BV97_00401 2.69e-103 308.0 COG1902@1|root,COG1902@2|Bacteria,1MVE0@1224|Proteobacteria,2TQPY@28211|Alphaproteobacteria,2K127@204457|Sphingomonadales 204457|Sphingomonadales C NADH flavin oxidoreductase NADH oxidase - - - - - - - - - - - - Oxidored_FMN k59_543028_1 1122137.AQXF01000002_gene321 1.19e-52 175.0 COG1561@1|root,COG1561@2|Bacteria,1MWRA@1224|Proteobacteria,2TS81@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Stress-induced protein yicC GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - - - - - - - - - - DUF1732,YicC_N k59_543028_2 314254.OA2633_00925 8.83e-58 189.0 COG1559@1|root,COG1559@2|Bacteria,1MUQF@1224|Proteobacteria,2TR89@28211|Alphaproteobacteria,43WJG@69657|Hyphomonadaceae 28211|Alphaproteobacteria S Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation mltG - - ko:K07082 - - - - ko00000 - - - YceG k59_1110383_1 1096930.L284_04305 8.66e-31 113.0 COG2246@1|root,COG2246@2|Bacteria,1NMVQ@1224|Proteobacteria,2VGT4@28211|Alphaproteobacteria 28211|Alphaproteobacteria S GtrA-like protein - - - - - - - - - - - - GtrA k59_719435_1 1502851.FG93_00046 2.25e-16 77.8 COG2994@1|root,COG2994@2|Bacteria,1RA26@1224|Proteobacteria,2UI28@28211|Alphaproteobacteria,3K1NV@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria O RTX toxin acyltransferase family - - - ko:K07389 ko05133,map05133 M00575 - - ko00000,ko00001,ko00002,ko01000 - - - HlyC k59_151446_1 1137281.D778_01086 3.81e-59 191.0 COG0111@1|root,COG0111@2|Bacteria,4NDVN@976|Bacteroidetes,1HWXS@117743|Flavobacteriia 976|Bacteroidetes EH Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family serA - 1.1.1.399,1.1.1.95 ko:K00058 ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230 M00020 R01513 RC00031 ko00000,ko00001,ko00002,ko01000,ko04147 - - - 2-Hacid_dh,2-Hacid_dh_C k59_488076_1 257313.BP1675 1.05e-37 139.0 COG3181@1|root,COG3181@2|Bacteria 2|Bacteria E Tripartite tricarboxylate transporter family receptor - - - - - - - - - - - - TctC k59_1279048_1 1385515.N791_05215 1.16e-27 112.0 COG0534@1|root,COG0534@2|Bacteria,1MV6B@1224|Proteobacteria,1RPGF@1236|Gammaproteobacteria,1X65W@135614|Xanthomonadales 135614|Xanthomonadales V MatE - - - ko:K03327 - - - - ko00000,ko02000 2.A.66.1 - - MatE k59_1057717_1 472759.Nhal_1845 6.25e-69 234.0 COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,1RMYC@1236|Gammaproteobacteria,1WX32@135613|Chromatiales 135613|Chromatiales P ATPase, P-type (transporting), HAD superfamily, subfamily IC - - 3.6.3.8 ko:K01537 - - - - ko00000,ko01000 3.A.3.2 - - Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3,LysM k59_658205_1 247634.GPB2148_2875 8.27e-69 228.0 COG0339@1|root,COG0339@2|Bacteria,1MU1K@1224|Proteobacteria,1RMAH@1236|Gammaproteobacteria,1J572@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Oligopeptidase A prlC GO:0003674,GO:0003824,GO:0004175,GO:0004222,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006465,GO:0006508,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016485,GO:0016787,GO:0019538,GO:0034641,GO:0034645,GO:0043170,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051604,GO:0070011,GO:0071704,GO:0090304,GO:0140096,GO:1901360,GO:1901564,GO:1901576 3.4.24.70 ko:K01414 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M3 k59_719439_2 1090318.ATTI01000001_gene426 8.82e-40 144.0 COG1940@1|root,COG1940@2|Bacteria,1R672@1224|Proteobacteria,2VGK4@28211|Alphaproteobacteria,2KE4H@204457|Sphingomonadales 204457|Sphingomonadales GK ROK family - - - - - - - - - - - - MarR_2,ROK k59_606295_1 222534.KB893746_gene2707 5.91e-50 173.0 COG3211@1|root,COG3211@2|Bacteria,2GJKE@201174|Actinobacteria 201174|Actinobacteria G Bacterial protein of unknown function (DUF839) - - - ko:K07093 - - - - ko00000 - - - DUF839 k59_208996_1 1229909.NSED_04325 1.13e-53 184.0 COG0046@1|root,arCOG00641@2157|Archaea,41S6S@651137|Thaumarchaeota 651137|Thaumarchaeota F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL purL - 6.3.5.3 ko:K01952 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04463 RC00010,RC01160 ko00000,ko00001,ko00002,ko01000 - - - AIRS,AIRS_C k59_208996_2 1229909.NSED_04320 8.69e-54 174.0 COG0047@1|root,arCOG00102@2157|Archaea,41SG3@651137|Thaumarchaeota 651137|Thaumarchaeota F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL purQ - 6.3.5.3 ko:K01952 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04463 RC00010,RC01160 ko00000,ko00001,ko00002,ko01000 - - - GATase_5 k59_1225626_1 1304872.JAGC01000003_gene2753 1.67e-53 196.0 COG0642@1|root,COG5002@1|root,COG2205@2|Bacteria,COG5002@2|Bacteria,1NRP8@1224|Proteobacteria,42M0Y@68525|delta/epsilon subdivisions,2WIR4@28221|Deltaproteobacteria,2M7T3@213115|Desulfovibrionales 28221|Deltaproteobacteria T histidine kinase A domain protein - - - - - - - - - - - - DUF4118,HATPase_c,HisKA,PAS_3,PAS_9,Response_reg k59_1568212_1 1229909.NSED_07115 6.99e-120 379.0 COG2132@1|root,COG3391@1|root,COG3794@1|root,arCOG02562@2157|Archaea,arCOG02926@2157|Archaea,arCOG03914@2157|Archaea 2157|Archaea Q Multicopper - - - - - - - - - - - - Lactonase k59_658234_1 436308.Nmar_1268 2.22e-42 146.0 COG0646@1|root,arCOG08715@2157|Archaea,41SWZ@651137|Thaumarchaeota 651137|Thaumarchaeota E homocysteine S-methyltransferase - - 2.1.1.13 ko:K00548 ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230 M00017 R00946,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 - - - S-methyl_trans k59_658234_2 436308.Nmar_1269 8.29e-24 98.6 COG0477@1|root,arCOG00130@2157|Archaea 2157|Archaea EGP Major facilitator superfamily - - - ko:K08153 - M00717 - - ko00000,ko00002,ko02000 2.A.1.2.8 - - MFS_1,PUCC k59_1335745_1 572477.Alvin_1648 2.06e-28 107.0 COG1534@1|root,COG1534@2|Bacteria,1N8K5@1224|Proteobacteria,1S67P@1236|Gammaproteobacteria,1X2GP@135613|Chromatiales 135613|Chromatiales J CRS1_YhbY - - - ko:K07574 - - - - ko00000,ko03009 - - - CRS1_YhbY k59_1335745_2 296591.Bpro_2677 4.03e-66 205.0 COG0782@1|root,COG0782@2|Bacteria,1RCXW@1224|Proteobacteria,2VQ16@28216|Betaproteobacteria,4ADKA@80864|Comamonadaceae 28216|Betaproteobacteria K Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides greA - - ko:K03624 - - - - ko00000,ko03021 - - - GreA_GreB,GreA_GreB_N k59_1335745_3 1123034.JMKP01000028_gene1388 6.38e-25 104.0 COG0458@1|root,COG0458@2|Bacteria,1MUDZ@1224|Proteobacteria,1RPIU@1236|Gammaproteobacteria,3NIFC@468|Moraxellaceae 1236|Gammaproteobacteria F Carbamoyl-phosphate synthetase ammonia chain carB GO:0000050,GO:0000166,GO:0003674,GO:0003824,GO:0004087,GO:0004088,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005951,GO:0006082,GO:0006139,GO:0006206,GO:0006220,GO:0006221,GO:0006520,GO:0006525,GO:0006526,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016053,GO:0016597,GO:0016874,GO:0016879,GO:0016884,GO:0017076,GO:0018130,GO:0019438,GO:0019627,GO:0019637,GO:0019693,GO:0019752,GO:0019856,GO:0030554,GO:0031406,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046112,GO:0046390,GO:0046394,GO:0046483,GO:0046872,GO:0055086,GO:0071704,GO:0071941,GO:0072527,GO:0072528,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494 6.3.5.5 ko:K01955 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - iAF1260.b0033,iBWG_1329.BWG_0031,iECDH10B_1368.ECDH10B_0034,iECDH1ME8569_1439.ECDH1ME8569_0031,iECUMN_1333.ECUMN_0034,iEcDH1_1363.EcDH1_3566,iJN746.PP_4723,iJO1366.b0033,iJR904.b0033,iPC815.YPO0482,iY75_1357.Y75_RS00170,iYL1228.KPN_00041 CPSase_L_D2,CPSase_L_D3,MGS k59_1733700_1 983920.Y88_3395 1.73e-148 435.0 COG3604@1|root,COG3604@2|Bacteria,1QTT3@1224|Proteobacteria,2TW04@28211|Alphaproteobacteria,2KEI9@204457|Sphingomonadales 204457|Sphingomonadales KT GAF domain - - - ko:K02584 ko02020,map02020 - - - ko00000,ko00001,ko03000 - - - GAF,HTH_8,Sigma54_activat k59_432203_1 1278073.MYSTI_01322 6.87e-13 65.1 2BR48@1|root,32K27@2|Bacteria,1Q2KM@1224|Proteobacteria,43878@68525|delta/epsilon subdivisions,2X3H6@28221|Deltaproteobacteria,2YW2M@29|Myxococcales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_432203_2 90813.JQMT01000001_gene191 3.56e-27 110.0 COG0019@1|root,COG0019@2|Bacteria,1MZ7Y@1224|Proteobacteria,1RQJ4@1236|Gammaproteobacteria 1236|Gammaproteobacteria E Belongs to the Orn Lys Arg decarboxylase class-II family speC - 4.1.1.17,4.1.1.20 ko:K01581,ko:K01586 ko00300,ko00330,ko00480,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map00330,map00480,map01100,map01110,map01120,map01130,map01230 M00016,M00134,M00525,M00526,M00527 R00451,R00670 RC00299 ko00000,ko00001,ko00002,ko01000 - - iJN746.PP_0864 Orn_Arg_deC_N,Orn_DAP_Arg_deC k59_1785581_2 666681.M301_0036 1.58e-39 142.0 COG2307@1|root,COG2307@2|Bacteria,1MVZK@1224|Proteobacteria,2VIB5@28216|Betaproteobacteria,2KKR6@206350|Nitrosomonadales 206350|Nitrosomonadales S A predicted alpha-helical domain with a conserved ER motif. - - - - - - - - - - - - Alpha-E k59_1279073_1 1121106.JQKB01000101_gene2446 1.65e-23 104.0 COG3267@1|root,COG3267@2|Bacteria,1MU3G@1224|Proteobacteria,2U1EJ@28211|Alphaproteobacteria,2JRHV@204441|Rhodospirillales 204441|Rhodospirillales U AAA domain - - - - - - - - - - - - AAA_22 k59_1621082_1 535289.Dtpsy_2706 3.68e-88 269.0 COG0306@1|root,COG0306@2|Bacteria,1MVXK@1224|Proteobacteria,2VI71@28216|Betaproteobacteria,4AA1C@80864|Comamonadaceae 28216|Betaproteobacteria P PFAM phosphate transporter pit - - ko:K03306 - - - - ko00000 2.A.20 - - PHO4 k59_41398_1 314285.KT71_07204 1.42e-81 255.0 COG0471@1|root,COG0471@2|Bacteria,1MUSA@1224|Proteobacteria,1RPU5@1236|Gammaproteobacteria,1J9PH@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P Sodium:sulfate symporter transmembrane region sdcS - - ko:K14445 - - - - ko00000,ko02000 2.A.47.1 - - Na_sulph_symp k59_1335760_1 1128421.JAGA01000003_gene3277 1.25e-46 157.0 COG2041@1|root,COG2041@2|Bacteria,2NQ7J@2323|unclassified Bacteria 2|Bacteria S Oxidoreductase molybdopterin binding domain - - - ko:K07147 - - - - ko00000,ko01000 - - - Oxidored_molyb k59_1110467_2 644282.Deba_0949 1.07e-11 63.5 COG0319@1|root,COG0319@2|Bacteria,1MZ67@1224|Proteobacteria,42W3M@68525|delta/epsilon subdivisions,2WRMB@28221|Deltaproteobacteria 28221|Deltaproteobacteria J Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA ybeY - - ko:K07042 - - - - ko00000,ko03009 - - - Cupin_2,UPF0054 k59_1397773_1 1415778.JQMM01000001_gene271 6.62e-27 110.0 COG0457@1|root,COG0457@2|Bacteria,1MYB8@1224|Proteobacteria,1RQIX@1236|Gammaproteobacteria,1J5FN@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O COG0457 FOG TPR repeat - - - - - - - - - - - - TPR_14,TPR_16,TPR_19,TPR_2,TPR_6,TPR_8 k59_1397773_2 314287.GB2207_06798 3.18e-25 102.0 COG3017@1|root,COG3017@2|Bacteria,1N02T@1224|Proteobacteria,1S91E@1236|Gammaproteobacteria,1J7BA@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein lolB GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0006807,GO:0008104,GO:0008150,GO:0008152,GO:0008289,GO:0009279,GO:0010876,GO:0016020,GO:0019538,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0033036,GO:0033218,GO:0034613,GO:0042157,GO:0042277,GO:0043170,GO:0044238,GO:0044462,GO:0044464,GO:0044872,GO:0044873,GO:0044874,GO:0051179,GO:0051641,GO:0051668,GO:0070727,GO:0071704,GO:0071723,GO:0071944,GO:0072657,GO:1901564 - ko:K02494 - - - - ko00000 - - - LolB k59_543085_1 314285.KT71_16346 1.75e-75 245.0 COG0624@1|root,COG0624@2|Bacteria,1MW20@1224|Proteobacteria,1S1X6@1236|Gammaproteobacteria,1J89Q@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Acetylornithine deacetylase Succinyl-diaminopimelate desuccinylase - - - - - - - - - - - - M20_dimer,Peptidase_M20 k59_1169668_1 1122611.KB904007_gene7735 8.05e-23 100.0 COG0165@1|root,COG0165@2|Bacteria,2GJ2A@201174|Actinobacteria,4EGRC@85012|Streptosporangiales 201174|Actinobacteria E Argininosuccinate lyase C-terminal argH GO:0003674,GO:0003824,GO:0004056,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016829,GO:0016840,GO:0016842,GO:0019752,GO:0030312,GO:0040007,GO:0042450,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.3.2.1 ko:K01755 ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230 M00029,M00844,M00845 R01086 RC00445,RC00447 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ASL_C2,Lyase_1 k59_1169668_2 675635.Psed_6659 2.55e-06 47.4 2DMMQ@1|root,32SHK@2|Bacteria,2IHWW@201174|Actinobacteria,4EC1N@85010|Pseudonocardiales 201174|Actinobacteria - - - - - - - - - - - - - - DUF3052 k59_889575_1 1381123.AYOD01000023_gene1474 4.78e-05 45.4 2DMP1@1|root,32SS8@2|Bacteria,1N0XZ@1224|Proteobacteria,2UBZ9@28211|Alphaproteobacteria,43JXR@69277|Phyllobacteriaceae 28211|Alphaproteobacteria S Protein of unknown function (DUF3237) MA20_18690 - - - - - - - - - - - DUF3237 k59_432228_1 386456.JQKN01000008_gene1374 9.1e-30 119.0 COG0128@1|root,arCOG04134@2157|Archaea,2XTC3@28890|Euryarchaeota,23NPJ@183925|Methanobacteria 183925|Methanobacteria E Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate aroA - 2.5.1.19 ko:K00800 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R03460 RC00350 ko00000,ko00001,ko00002,ko01000 - - - EPSP_synthase k59_209056_1 1121943.KB899992_gene2300 4.71e-77 241.0 COG0472@1|root,COG0472@2|Bacteria,1MUTK@1224|Proteobacteria,1RNIG@1236|Gammaproteobacteria,1XIQQ@135619|Oceanospirillales 135619|Oceanospirillales M First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan mraY - 2.7.8.13 ko:K01000 ko00550,ko01100,ko01502,map00550,map01100,map01502 - R05629,R05630 RC00002,RC02753 ko00000,ko00001,ko01000,ko01011 9.B.146 - - Glycos_transf_4,MraY_sig1 k59_1397788_1 1112217.PPL19_22270 1.88e-74 236.0 COG1234@1|root,COG1234@2|Bacteria,1Q4PW@1224|Proteobacteria,1RR5K@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA rnz GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004527,GO:0004532,GO:0004540,GO:0005488,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016796,GO:0016891,GO:0016893,GO:0016896,GO:0031123,GO:0034414,GO:0034470,GO:0034641,GO:0034660,GO:0042779,GO:0042780,GO:0042781,GO:0043167,GO:0043169,GO:0043170,GO:0043628,GO:0044237,GO:0044238,GO:0046483,GO:0046872,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0090503,GO:0140098,GO:1901360,GO:1905267 3.1.26.11 ko:K00784 ko03013,map03013 - - - ko00000,ko00001,ko01000,ko03016 - - - Lactamase_B_2 k59_1169672_1 546262.NEICINOT_03966 0.000887 48.5 COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,2VI4Q@28216|Betaproteobacteria,2KQHF@206351|Neisseriales 206351|Neisseriales O Belongs to the peptidase S1C family htrA - 3.4.21.107 ko:K04771 ko01503,ko02020,map01503,map02020 M00728 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 - - - PDZ_2,Trypsin_2 k59_488131_1 1177154.Y5S_00043 5.52e-63 214.0 COG0834@1|root,COG4623@1|root,COG0834@2|Bacteria,COG4623@2|Bacteria,1MWDS@1224|Proteobacteria,1RM8W@1236|Gammaproteobacteria,1XI7H@135619|Oceanospirillales 135619|Oceanospirillales M Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella - - - ko:K18691 - - - - ko00000,ko01000,ko01011 - - - SBP_bac_3,SLT k59_1785637_1 1279019.ARQK01000036_gene1620 2.97e-34 130.0 COG0130@1|root,COG0130@2|Bacteria,1MV0N@1224|Proteobacteria,1RMKP@1236|Gammaproteobacteria,1WVXW@135613|Chromatiales 135613|Chromatiales J Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs truB - 5.4.99.25 ko:K03177 - - - - ko00000,ko01000,ko03016 - - - TruB-C_2,TruB_C_2,TruB_N k59_1621124_1 1280946.HY29_10400 7.6e-67 214.0 COG0491@1|root,COG0491@2|Bacteria,1R6YC@1224|Proteobacteria,2VF7N@28211|Alphaproteobacteria,43Z2Z@69657|Hyphomonadaceae 28211|Alphaproteobacteria S Metallo-beta-lactamase superfamily - - - - - - - - - - - - Lactamase_B k59_1397796_1 279714.FuraDRAFT_1434 1.03e-88 271.0 COG0226@1|root,COG0226@2|Bacteria,1MUAZ@1224|Proteobacteria,2VIJV@28216|Betaproteobacteria,2KPQ9@206351|Neisseriales 206351|Neisseriales P Part of the ABC transporter complex PstSACB involved in phosphate import pstS - - ko:K02040 ko02010,ko02020,ko05152,map02010,map02020,map05152 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - PBP_like_2 k59_774274_1 42256.RradSPS_1778 0.000256 44.3 COG0584@1|root,COG0584@2|Bacteria,2GJ5W@201174|Actinobacteria,4CQHH@84995|Rubrobacteria 84995|Rubrobacteria C glycerophosphoryl diester phosphodiesterase - - 3.1.4.46 ko:K01126 ko00564,map00564 - R01030,R01470 RC00017,RC00425 ko00000,ko00001,ko01000 - - - GDPD k59_774274_2 338963.Pcar_0100 8.16e-147 434.0 COG0215@1|root,COG0215@2|Bacteria,1MV8H@1224|Proteobacteria,42M04@68525|delta/epsilon subdivisions,2WJJD@28221|Deltaproteobacteria,43S9P@69541|Desulfuromonadales 28221|Deltaproteobacteria J DALR_2 cysS GO:0000166,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.1.1.16 ko:K01883 ko00970,map00970 M00359,M00360 R03650 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DALR_2,tRNA-synt_1e,tRNA-synt_1g k59_662692_1 754476.Q7A_3106 1.8e-68 217.0 COG3039@1|root,COG3039@2|Bacteria,1Q9AW@1224|Proteobacteria,1RNU1@1236|Gammaproteobacteria,460GH@72273|Thiotrichales 72273|Thiotrichales L PFAM Transposase DDE domain - - - - - - - - - - - - DDE_Tnp_1_3 k59_385284_1 1206733.BAGC01000052_gene2456 8.65e-33 128.0 COG0318@1|root,COG0318@2|Bacteria,2GJR0@201174|Actinobacteria,4FVT8@85025|Nocardiaceae 201174|Actinobacteria IQ AMP-binding enzyme - - 6.1.3.1 ko:K22319 - - - - ko00000,ko01000 - - - AMP-binding,Abhydrolase_1 k59_1339617_2 504487.JCM19302_3363 6.23e-53 174.0 2E3AK@1|root,32SYY@2|Bacteria,4NSTE@976|Bacteroidetes,1IIAV@117743|Flavobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_1114384_1 713586.KB900536_gene1053 1.17e-10 60.8 COG0817@1|root,COG0817@2|Bacteria,1MUJI@1224|Proteobacteria,1RQPJ@1236|Gammaproteobacteria,1WW8M@135613|Chromatiales 135613|Chromatiales L Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group ruvC - 3.1.22.4 ko:K01159 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - RuvC k59_1114384_2 697282.Mettu_3552 2.53e-82 250.0 COG0217@1|root,COG0217@2|Bacteria,1MW3X@1224|Proteobacteria,1RP5N@1236|Gammaproteobacteria,1XDV4@135618|Methylococcales 135618|Methylococcales K transcriptional regulatory protein - - - - - - - - - - - - Transcrip_reg k59_610336_1 436308.Nmar_1393 2.76e-82 248.0 COG0164@1|root,arCOG04121@2157|Archaea,41SK9@651137|Thaumarchaeota 651137|Thaumarchaeota L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids rnhB - 3.1.26.4 ko:K03470 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - RNase_HII k59_610336_2 436308.Nmar_1392 2.04e-40 139.0 COG0513@1|root,arCOG00078@2157|Archaea,41SM2@651137|Thaumarchaeota 651137|Thaumarchaeota J Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA flpA - - ko:K04795 - - - - ko00000,ko03009 - - - Fibrillarin k59_774284_1 253839.SSNG_04055 8.93e-22 103.0 COG0318@1|root,COG0318@2|Bacteria,2GIUC@201174|Actinobacteria 201174|Actinobacteria IQ PFAM AMP-dependent synthetase and ligase fadD16 - 6.2.1.41 ko:K18687 ko00984,ko01100,ko01120,map00984,map01100,map01120 - R10769 RC00004,RC00014 ko00000,ko00001,ko01000 - - - AMP-binding,AMP-binding_C k59_1115592_1 388051.AUFE01000093_gene44 1.65e-59 193.0 COG3568@1|root,COG3568@2|Bacteria,1MVN7@1224|Proteobacteria,2VPRV@28216|Betaproteobacteria,1K3CH@119060|Burkholderiaceae 28216|Betaproteobacteria L Endonuclease Exonuclease phosphatase - - - - - - - - - - - - Exo_endo_phos k59_945717_1 1122137.AQXF01000002_gene420 3.92e-35 130.0 COG4108@1|root,COG4108@2|Bacteria,1MU7X@1224|Proteobacteria,2TRP5@28211|Alphaproteobacteria 28211|Alphaproteobacteria J Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP prfC - - ko:K02837 - - - - ko00000,ko03012 - - - GTP_EFTU,GTP_EFTU_D2,RF3_C k59_834460_1 1088721.NSU_1548 2.45e-115 357.0 COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,2TRJF@28211|Alphaproteobacteria,2K1KW@204457|Sphingomonadales 204457|Sphingomonadales L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity polA - 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1 k59_1001546_1 1071679.BG57_05100 6.58e-138 407.0 COG0129@1|root,COG0129@2|Bacteria,1MV4I@1224|Proteobacteria,2VKKY@28216|Betaproteobacteria,1K1H9@119060|Burkholderiaceae 28216|Betaproteobacteria EG Belongs to the IlvD Edd family - - 4.2.1.9 ko:K01687 ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R01209,R04441,R05070 RC00468,RC01714 ko00000,ko00001,ko00002,ko01000 - - - ILVD_EDD k59_1626154_1 1229909.NSED_01330 3.13e-94 288.0 COG1007@1|root,arCOG01540@2157|Archaea,41SDU@651137|Thaumarchaeota 651137|Thaumarchaeota C NADH ubiquinone oxidoreductase subunit 2 (Chain N) - - 1.5.98.3 ko:K22169 - - - - ko00000,ko01000 3.D.9.1 - - Proton_antipo_M k59_1454346_1 1004785.AMBLS11_15210 5.21e-154 449.0 COG4993@1|root,COG4993@2|Bacteria,1MUQX@1224|Proteobacteria,1RN5D@1236|Gammaproteobacteria,4663U@72275|Alteromonadaceae 1236|Gammaproteobacteria G COG4993 Glucose dehydrogenase pedH - 1.1.2.8 ko:K00114 ko00010,ko00625,ko01100,ko01110,ko01120,ko01130,map00010,map00625,map01100,map01110,map01120,map01130 - R05062,R05198,R05285 RC00087,RC00088,RC01039 ko00000,ko00001,ko01000 - - - PQQ,PQQ_2 k59_1681501_1 717774.Marme_0984 4.91e-10 65.1 2BX7Z@1|root,2ZBYH@2|Bacteria,1RFFM@1224|Proteobacteria,1S5CF@1236|Gammaproteobacteria,1XPRN@135619|Oceanospirillales 135619|Oceanospirillales S F plasmid transfer operon, TraF, protein - - - - - - - - - - - - TraF_2 k59_834470_2 1249627.D779_4030 5.41e-74 245.0 COG4222@1|root,COG5276@1|root,COG4222@2|Bacteria,COG5276@2|Bacteria,1MVDD@1224|Proteobacteria,1T1Z4@1236|Gammaproteobacteria 1236|Gammaproteobacteria F Esterase-like activity of phytase - - - - - - - - - - - - Collagen,Phytase-like k59_386584_1 316407.85675988 6.29e-51 167.0 COG0767@1|root,COG0767@2|Bacteria,1MVPN@1224|Proteobacteria,1RM9H@1236|Gammaproteobacteria,3XM51@561|Escherichia 1236|Gammaproteobacteria Q Part of the ABC transporter complex MlaFEDB that actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane mlaE GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K02066 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - MlaE k59_386584_2 316407.85675989 7.36e-115 333.0 COG1127@1|root,COG1127@2|Bacteria,1MUSD@1224|Proteobacteria,1RMCJ@1236|Gammaproteobacteria,3XN7D@561|Escherichia 1236|Gammaproteobacteria P Part of the ABC transporter complex MlaFEDB that actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane. Probably responsible for energy coupling to the transport system mlaF GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0008144,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - ko:K02065 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - ABC_tran k59_1516036_1 498211.CJA_0533 2.4e-09 63.2 COG3866@1|root,COG3866@2|Bacteria,1R9Q3@1224|Proteobacteria,1S3TY@1236|Gammaproteobacteria 1236|Gammaproteobacteria G Pectate lyase pel GO:0005575,GO:0005576 4.2.2.2 ko:K01728 ko00040,ko02024,map00040,map02024 - R02361,R06240 RC00049,RC00705 ko00000,ko00001,ko01000 - - - Pec_lyase_C k59_724893_1 1137281.D778_01747 1.21e-112 337.0 COG0534@1|root,COG0534@2|Bacteria,4NG7Q@976|Bacteroidetes,1HYBI@117743|Flavobacteriia 976|Bacteroidetes V Na -driven multidrug efflux pump dinF - - ko:K03327 - - - - ko00000,ko02000 2.A.66.1 - - MatE k59_775345_1 331869.BAL199_10607 2.33e-76 248.0 COG1123@1|root,COG4172@2|Bacteria,1MU09@1224|Proteobacteria,2TQP0@28211|Alphaproteobacteria,4BPA1@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria P Oligopeptide/dipeptide transporter, C-terminal region gsiA1 - - ko:K02031,ko:K02032 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - ABC_tran,oligo_HPY k59_1001570_1 1470593.BW43_01300 5.73e-27 115.0 COG1020@1|root,COG1020@2|Bacteria,1QK4F@1224|Proteobacteria,1RPAG@1236|Gammaproteobacteria 1236|Gammaproteobacteria Q COG1020 Non-ribosomal peptide synthetase modules and related proteins - - - - - - - - - - - - AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase k59_548707_1 1088721.NSU_0916 2.51e-120 354.0 COG0508@1|root,COG0508@2|Bacteria,1MUJD@1224|Proteobacteria,2TS5N@28211|Alphaproteobacteria,2K18R@204457|Sphingomonadales 204457|Sphingomonadales C The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) sucB - 2.3.1.61 ko:K00658 ko00020,ko00310,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00032 R02570,R02571,R08549 RC00004,RC02727,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - 2-oxoacid_dh,Biotin_lipoyl,E3_binding k59_46394_1 1229909.NSED_03225 2.2e-134 385.0 COG0391@1|root,arCOG04395@2157|Archaea,41SCH@651137|Thaumarchaeota 651137|Thaumarchaeota H Uncharacterised protein family UPF0052 - - 2.7.8.28 ko:K11212 ko00680,ko01120,map00680,map01120 M00378 R09398 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - UPF0052 k59_1681536_1 1122137.AQXF01000001_gene2850 1.48e-113 333.0 COG1250@1|root,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,2TR8E@28211|Alphaproteobacteria 28211|Alphaproteobacteria I 3-hydroxyacyl-coa dehydrogenase hbdA - 1.1.1.157 ko:K00074 ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120 - R01976,R05576,R06941 RC00029,RC00117 ko00000,ko00001,ko01000 - - - 3HCDH,3HCDH_N k59_1230406_1 118173.KB235914_gene3296 5.12e-40 147.0 COG1028@1|root,COG3347@1|root,COG1028@2|Bacteria,COG3347@2|Bacteria,1G0Q0@1117|Cyanobacteria,1H8S9@1150|Oscillatoriales 1117|Cyanobacteria IQ Class II Aldolase and Adducin N-terminal domain - - - - - - - - - - - - Aldolase_II,adh_short,adh_short_C2 k59_1230406_2 471870.BACINT_03026 6.31e-10 59.3 COG1830@1|root,COG1830@2|Bacteria,4P0GF@976|Bacteroidetes,2FP1C@200643|Bacteroidia,4APB5@815|Bacteroidaceae 976|Bacteroidetes G DeoC/LacD family aldolase - - 2.3.1.245 ko:K08321 ko02024,map02024 - - - ko00000,ko00001,ko01000 - - - DeoC k59_386595_1 1297865.APJD01000007_gene1957 5.33e-96 296.0 COG0654@1|root,COG0654@2|Bacteria,1MXEW@1224|Proteobacteria,2TRRC@28211|Alphaproteobacteria,3JV1F@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria CH Function proposed based on presence of conserved amino acid motif, structural feature or limited homology MA20_42420 - 1.14.13.218 ko:K20940 ko00405,ko01130,map00405,map01130 M00835 - - ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_3 k59_1001575_1 1121948.AUAC01000002_gene1570 9.08e-30 122.0 COG3485@1|root,COG3485@2|Bacteria,1QUNE@1224|Proteobacteria,2U26Y@28211|Alphaproteobacteria 28211|Alphaproteobacteria Q Domain of unknown function DUF11 - - - - - - - - - - - - DUF11 k59_437589_1 330214.NIDE0848 3.18e-81 248.0 COG0755@1|root,COG0755@2|Bacteria,3J0NY@40117|Nitrospirae 40117|Nitrospirae O Cytochrome C assembly protein - - - - - - - - - - - - Cytochrom_C_asm k59_102295_1 1121405.dsmv_1267 1.04e-71 241.0 COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,42M8F@68525|delta/epsilon subdivisions,2WIU0@28221|Deltaproteobacteria,2MIS4@213118|Desulfobacterales 28221|Deltaproteobacteria P ATPase, P-type (transporting), HAD superfamily, subfamily IC pacL - 3.6.3.8 ko:K01537 - - - - ko00000,ko01000 3.A.3.2 - - Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3 k59_1626210_1 754331.AEME01000001_gene2699 8.68e-98 291.0 COG1426@1|root,COG1426@2|Bacteria,1N240@1224|Proteobacteria,1RQMV@1236|Gammaproteobacteria,3XNBZ@561|Escherichia 1236|Gammaproteobacteria S Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis rodZ GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0008360,GO:0016020,GO:0016021,GO:0022603,GO:0022604,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0065007,GO:0065008,GO:0071944 - ko:K15539 - - - - ko00000 - - - DUF4115,HTH_25 k59_1626210_2 1197719.A464_2636 1.8e-74 232.0 COG0820@1|root,COG0820@2|Bacteria,1MUYK@1224|Proteobacteria,1RMUI@1236|Gammaproteobacteria,3ZJ7Q@590|Salmonella 1236|Gammaproteobacteria J Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs rlmN GO:0000049,GO:0000154,GO:0001510,GO:0002935,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008173,GO:0008175,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016426,GO:0016433,GO:0016740,GO:0016741,GO:0022613,GO:0030488,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0070040,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0140098,GO:0140101,GO:0140102,GO:1901360,GO:1901363 2.1.1.192 ko:K06941 - - - - ko00000,ko01000,ko03009 - - - Radical_SAM k59_1001587_1 472759.Nhal_3693 2.01e-91 276.0 COG1005@1|root,COG1005@2|Bacteria,1MU2R@1224|Proteobacteria,1RQE9@1236|Gammaproteobacteria,1WXDH@135613|Chromatiales 135613|Chromatiales C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone nuoH - 1.6.5.3 ko:K00337 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - NADHdh k59_1062812_2 351348.Maqu_0719 9.71e-24 95.1 COG0087@1|root,COG0087@2|Bacteria,1MUST@1224|Proteobacteria,1RMK9@1236|Gammaproteobacteria,465E3@72275|Alteromonadaceae 1236|Gammaproteobacteria J One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit rplC GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02906 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L3 k59_1284760_1 313603.FB2170_10916 7.9e-17 77.8 COG0040@1|root,COG0040@2|Bacteria,4NDW8@976|Bacteroidetes,1HWP3@117743|Flavobacteriia,2PH47@252356|Maribacter 976|Bacteroidetes E ATP phosphoribosyltransferase hisG GO:0000105,GO:0003674,GO:0003824,GO:0003879,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.17 ko:K00765 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R01071 RC02819,RC03200 ko00000,ko00001,ko00002,ko01000 - - - HisG,HisG_C k59_1284760_2 1506583.JQJY01000001_gene255 3.13e-31 122.0 COG0141@1|root,COG0141@2|Bacteria,4NFPZ@976|Bacteroidetes,1HZ69@117743|Flavobacteriia,2NSJG@237|Flavobacterium 976|Bacteroidetes E Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine hisD GO:0000105,GO:0003674,GO:0003824,GO:0004399,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0052803,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.23 ko:K00013 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R01158,R01163,R03012 RC00099,RC00242,RC00463 ko00000,ko00001,ko00002,ko01000 - - - Histidinol_dh k59_1626222_1 46429.BV95_00388 1.57e-10 71.6 COG4773@1|root,COG4773@2|Bacteria,1QTXJ@1224|Proteobacteria,2UNSU@28211|Alphaproteobacteria,2K17K@204457|Sphingomonadales 204457|Sphingomonadales P receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_1626222_2 1149133.ppKF707_5788 9.42e-145 424.0 COG1902@1|root,COG1902@2|Bacteria,1MVE0@1224|Proteobacteria,1RTA0@1236|Gammaproteobacteria,1YHYD@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria C NADH:flavin oxidoreductase / NADH oxidase family - - - - - - - - - - - - Oxidored_FMN k59_386624_1 574087.Acear_0926 1.07e-69 217.0 COG1794@1|root,COG1794@2|Bacteria,1V2G1@1239|Firmicutes,24IST@186801|Clostridia 186801|Clostridia M racemase activity, acting on amino acids and derivatives - - - - - - - - - - - - - k59_663957_1 1088721.NSU_0847 8.27e-131 385.0 COG1292@1|root,COG1292@2|Bacteria,1MV0K@1224|Proteobacteria,2TQR4@28211|Alphaproteobacteria,2K2SA@204457|Sphingomonadales 204457|Sphingomonadales M Belongs to the BCCT transporter (TC 2.A.15) family - - - ko:K02168 - - - - ko00000,ko02000 2.A.15.1.3,2.A.15.1.4 - - BCCT k59_386633_1 1177154.Y5S_00222 7.77e-44 156.0 COG4783@1|root,COG4783@2|Bacteria,1QV70@1224|Proteobacteria,1RQJV@1236|Gammaproteobacteria,1XME4@135619|Oceanospirillales 135619|Oceanospirillales S Zn-dependent protease - - - - - - - - - - - - Peptidase_M48 k59_834515_1 199310.c3110 1.51e-88 271.0 COG1502@1|root,COG1502@2|Bacteria,1MVPU@1224|Proteobacteria,1RN1V@1236|Gammaproteobacteria,3XP42@561|Escherichia 1236|Gammaproteobacteria I CDP-diacylglycerol-serine O-phosphatidyltransferase activity pssA GO:0003674,GO:0003824,GO:0003882,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0016740,GO:0016772,GO:0016780,GO:0017169,GO:0044424,GO:0044444,GO:0044464,GO:0071944 2.7.8.8 ko:K00998 ko00260,ko00564,ko01100,ko01110,map00260,map00564,map01100,map01110 M00093 R01800 RC00002,RC00017,RC02795 ko00000,ko00001,ko00002,ko01000 - - iECH74115_1262.ECH74115_3822,iECSP_1301.ECSP_3532,iYL1228.KPN_02908 PLDc_2,Regulator_TrmB k59_1791114_1 1172188.KB911821_gene1505 6.09e-06 51.6 COG3291@1|root,COG3291@2|Bacteria,2GP3U@201174|Actinobacteria,4FG1Y@85021|Intrasporangiaceae 201174|Actinobacteria S Pkd domain containing protein - - - - - - - - - - - - - k59_724956_1 742159.HMPREF0004_0470 3.41e-44 160.0 COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,2VH16@28216|Betaproteobacteria,3T2KW@506|Alcaligenaceae 28216|Betaproteobacteria JKL Belongs to the DEAD box helicase family rhlE1 GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008026,GO:0008104,GO:0008150,GO:0008186,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032991,GO:0033036,GO:0035770,GO:0036464,GO:0042623,GO:0043186,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044424,GO:0044444,GO:0044464,GO:0045495,GO:0051179,GO:0060293,GO:0070035,GO:0140098,GO:1990904 - - - - - - - - - - DEAD,Helicase_C k59_329882_1 1266914.ATUK01000010_gene1130 7.87e-39 137.0 COG4067@1|root,COG4067@2|Bacteria,1RGX8@1224|Proteobacteria,1S5YR@1236|Gammaproteobacteria,1WYD4@135613|Chromatiales 135613|Chromatiales O Putative ATP-dependant zinc protease - - - - - - - - - - - - Zn_protease k59_1174506_1 351348.Maqu_0856 1.04e-41 138.0 COG0211@1|root,COG0211@2|Bacteria,1MZGH@1224|Proteobacteria,1S8R2@1236|Gammaproteobacteria,467SE@72275|Alteromonadaceae 1236|Gammaproteobacteria J Belongs to the bacterial ribosomal protein bL27 family rpmA GO:0000027,GO:0001558,GO:0003674,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040008,GO:0042254,GO:0042255,GO:0042256,GO:0042273,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044087,GO:0044089,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0044877,GO:0048518,GO:0050789,GO:0050794,GO:0051128,GO:0065003,GO:0065007,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090069,GO:0090070,GO:1901564,GO:1901566,GO:1901576,GO:1902626,GO:1990904 - ko:K02899 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L27 k59_272098_1 1415778.JQMM01000001_gene770 5.41e-69 228.0 COG4206@1|root,COG4206@2|Bacteria,1MW63@1224|Proteobacteria,1RMFJ@1236|Gammaproteobacteria,1J6E9@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P TonB dependent receptor btuB - - ko:K16092 - - - - ko00000,ko02000 1.B.14.3 - - Plug,TonB_dep_Rec k59_1341052_1 526225.Gobs_3276 0.000344 42.4 2E49S@1|root,32Z5G@2|Bacteria,2IHN1@201174|Actinobacteria,4EXIZ@85013|Frankiales 201174|Actinobacteria S Protein of unknown function (DUF3040) - - - - - - - - - - - - DUF3040 k59_1341052_2 710111.FraQA3DRAFT_3959 6.38e-18 85.5 COG0406@1|root,COG0406@2|Bacteria,2GMXF@201174|Actinobacteria,4ESMJ@85013|Frankiales 201174|Actinobacteria G phosphoglycerate mutase - GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 - - - - - - - - - - His_Phos_1 k59_329889_1 693977.Deipr_0327 1.73e-06 56.6 COG2032@1|root,COG3386@1|root,COG2032@2|Bacteria,COG3386@2|Bacteria 2|Bacteria G gluconolactonase activity sodC - 1.15.1.1,3.1.1.17 ko:K01053,ko:K04565 ko00030,ko00053,ko00930,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,ko04146,ko04213,ko05014,ko05016,ko05020,map00030,map00053,map00930,map01100,map01110,map01120,map01130,map01200,map01220,map04146,map04213,map05014,map05016,map05020 M00129 R01519,R02933,R03751 RC00537,RC00983 ko00000,ko00001,ko00002,ko01000,ko04147 - - - SGL,Sod_Cu k59_329889_2 313606.M23134_07903 9.08e-32 116.0 COG0346@1|root,COG0346@2|Bacteria,4NQ3F@976|Bacteroidetes,47VM6@768503|Cytophagia 976|Bacteroidetes E Glyoxalase-like domain - - - - - - - - - - - - Glyoxalase k59_329889_3 743719.PaelaDRAFT_2703 3.64e-76 250.0 COG4447@1|root,COG4447@2|Bacteria,1U6PZ@1239|Firmicutes,4HTXT@91061|Bacilli,26RMP@186822|Paenibacillaceae 91061|Bacilli G Cellulose binding domain - - - - - - - - - - - - BNR k59_1230510_1 485913.Krac_9455 2e-65 210.0 COG0667@1|root,COG0667@2|Bacteria,2G6BF@200795|Chloroflexi 2|Bacteria C PFAM aldo keto reductase - - 1.1.1.91 ko:K05882 - - - - ko00000,ko01000 - - - Aldo_ket_red k59_214119_1 1453501.JELR01000002_gene936 5.05e-78 242.0 COG2897@1|root,COG2897@2|Bacteria,1MW4B@1224|Proteobacteria,1RSQ3@1236|Gammaproteobacteria,465W6@72275|Alteromonadaceae 1236|Gammaproteobacteria P Rhodanese Homology Domain rhdA - 2.8.1.1,2.8.1.2 ko:K01011 ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122 - R01931,R03105,R03106 RC00214 ko00000,ko00001,ko01000 - - - Rhodanese k59_1516162_1 998674.ATTE01000001_gene2055 3.1e-83 270.0 COG0495@1|root,COG0495@2|Bacteria,1MV47@1224|Proteobacteria,1RP14@1236|Gammaproteobacteria,4609P@72273|Thiotrichales 72273|Thiotrichales J Belongs to the class-I aminoacyl-tRNA synthetase family leuS - 6.1.1.4 ko:K01869 ko00970,map00970 M00359,M00360 R03657 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - Anticodon_1,tRNA-synt_1,tRNA-synt_1_2 k59_329897_1 511.JT27_17880 8.36e-22 99.4 COG2373@1|root,COG2373@2|Bacteria,1MV7J@1224|Proteobacteria,2VI2R@28216|Betaproteobacteria,3T2P7@506|Alcaligenaceae 28216|Betaproteobacteria S Alpha-2-Macroglobulin - - - ko:K06894 - - - - ko00000 - - - A2M,A2M_N,A2M_N_2,A2M_comp,MG1,Thiol-ester_cl k59_1115736_1 1045855.DSC_08255 3.66e-72 238.0 COG0348@1|root,COG0348@2|Bacteria,1MVFY@1224|Proteobacteria,1RMDI@1236|Gammaproteobacteria,1X4FV@135614|Xanthomonadales 135614|Xanthomonadales C IG-like fold at C-terminal of FixG, putative oxidoreductase - - - - - - - - - - - - Fer4_18,Fer4_5,FixG_C k59_1115736_2 443143.GM18_1097 2.11e-23 98.6 COG2010@1|root,COG2010@2|Bacteria,1Q5W7@1224|Proteobacteria,43EX5@68525|delta/epsilon subdivisions,2X9Z2@28221|Deltaproteobacteria,43V67@69541|Desulfuromonadales 28221|Deltaproteobacteria C Cytochrome c - - - ko:K00406 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00156 - - ko00000,ko00001,ko00002 3.D.4.3 - - Cytochrome_CBB3 k59_102372_1 1120953.AUBH01000001_gene866 8.75e-125 359.0 COG1788@1|root,COG1788@2|Bacteria,1MVEI@1224|Proteobacteria,1RNXB@1236|Gammaproteobacteria,4644U@72275|Alteromonadaceae 1236|Gammaproteobacteria I COG1788 Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit scoA - 2.8.3.5 ko:K01028 ko00072,ko00280,ko00650,map00072,map00280,map00650 - R00410 RC00014 ko00000,ko00001,ko01000 - - iJN746.PP_3122 CoA_trans k59_1001668_1 797302.Halru_2234 3.81e-52 174.0 arCOG06481@1|root,arCOG06481@2157|Archaea,2XV5Y@28890|Euryarchaeota,23TY8@183963|Halobacteria 183963|Halobacteria - - - - - - - - - - - - - - - k59_102380_1 395963.Bind_2085 4.29e-33 123.0 COG2084@1|root,COG2084@2|Bacteria,1MUD0@1224|Proteobacteria,2TT7P@28211|Alphaproteobacteria,3NC1B@45404|Beijerinckiaceae 28211|Alphaproteobacteria I NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase MA20_16450 - 1.1.1.411 ko:K08319 - - - - ko00000,ko01000 - - - NAD_binding_11,NAD_binding_2 k59_102380_2 375286.mma_3587 5.59e-22 89.0 2EP1T@1|root,315BD@2|Bacteria,1PVCW@1224|Proteobacteria,2WB83@28216|Betaproteobacteria,4757Y@75682|Oxalobacteraceae 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_1230538_1 519989.ECTPHS_01134 2.49e-83 269.0 COG0550@1|root,COG0550@2|Bacteria,1MUFZ@1224|Proteobacteria,1RNZ2@1236|Gammaproteobacteria,1WWWP@135613|Chromatiales 135613|Chromatiales L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone topA - 5.99.1.2 ko:K03168 - - - - ko00000,ko01000,ko03032,ko03400 - - - Topo_Zn_Ribbon,Topoisom_bac,Toprim,Toprim_C_rpt,zf-C4_Topoisom k59_895199_1 1352941.M877_38340 3.65e-31 123.0 COG1070@1|root,COG1070@2|Bacteria,2GISK@201174|Actinobacteria 201174|Actinobacteria G Carbohydrate kinase rhaB - 2.7.1.5 ko:K00848 ko00040,ko00051,ko01120,map00040,map00051,map01120 - R01902,R03014 RC00002,RC00017 ko00000,ko00001,ko01000 - - - FGGY_C,FGGY_N k59_1174538_1 1088721.NSU_0677 5.84e-95 286.0 COG1463@1|root,COG1463@2|Bacteria,1MU4B@1224|Proteobacteria,2U1JN@28211|Alphaproteobacteria,2K12E@204457|Sphingomonadales 204457|Sphingomonadales Q ABC-type transport system involved in resistance to organic solvents, periplasmic component - - - ko:K02067 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - MlaD k59_386731_1 436308.Nmar_0450 3.91e-83 250.0 COG1676@1|root,arCOG01701@2157|Archaea,41SJY@651137|Thaumarchaeota 651137|Thaumarchaeota L tRNA intron endonuclease, N-terminal domain - - 4.6.1.16 ko:K01170 - - - - ko00000,ko01000,ko03016 - - - tRNA_int_endo,tRNA_int_endo_N k59_1523950_2 398578.Daci_0528 2.76e-29 115.0 COG0665@1|root,COG0665@2|Bacteria,1MVIZ@1224|Proteobacteria,2VH1D@28216|Betaproteobacteria,4A9ZE@80864|Comamonadaceae 28216|Betaproteobacteria C PFAM FAD dependent oxidoreductase dad2 - 1.4.5.1 ko:K00285 ko00360,map00360 - R01374,R09493 RC00006,RC00025 ko00000,ko00001,ko01000 - - - DAO,FAD_binding_2 k59_1581474_1 525909.Afer_0907 3.21e-77 248.0 COG1222@1|root,COG1222@2|Bacteria,2GMR1@201174|Actinobacteria,4CMRU@84992|Acidimicrobiia 84992|Acidimicrobiia O Proteasomal ATPase OB/ID domain arc - - ko:K13527 ko03050,map03050 M00342 - - ko00000,ko00001,ko00002,ko03051 - - - AAA,Prot_ATP_ID_OB k59_1581474_2 1283287.KB822579_gene2210 4.11e-32 124.0 COG4122@1|root,COG4122@2|Bacteria,2GJGI@201174|Actinobacteria,4DMZX@85009|Propionibacteriales 201174|Actinobacteria S Pup-ligase protein dop GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0006464,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0010498,GO:0016787,GO:0016810,GO:0016811,GO:0017076,GO:0018193,GO:0018205,GO:0019538,GO:0019941,GO:0030163,GO:0030554,GO:0032446,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0036211,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0051603,GO:0070490,GO:0070647,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575 3.5.1.119 ko:K20814 - - - - ko00000,ko01000,ko03051 - - - Pup_ligase k59_1070636_1 1280953.HOC_10863 3.57e-130 381.0 COG0667@1|root,COG0667@2|Bacteria,1MV2Y@1224|Proteobacteria,2TSKV@28211|Alphaproteobacteria,43X72@69657|Hyphomonadaceae 28211|Alphaproteobacteria C aldo keto reductase - - - - - - - - - - - - Aldo_ket_red k59_1123546_1 1278307.KB906973_gene1375 1.56e-09 62.8 COG3524@1|root,COG3524@2|Bacteria,1R3ZY@1224|Proteobacteria,1RPZH@1236|Gammaproteobacteria,2QJ3E@267894|Psychromonadaceae 1236|Gammaproteobacteria M COG3524 Capsule polysaccharide export protein kpsE - - ko:K10107 ko02010,map02010 M00249 - - ko00000,ko00001,ko00002,ko02000 3.A.1.101 - - - k59_1123546_2 1208583.COMX_02195 1.86e-28 115.0 COG1134@1|root,COG1134@2|Bacteria,1MWWC@1224|Proteobacteria,2U61R@28211|Alphaproteobacteria,2JSJT@204441|Rhodospirillales 204441|Rhodospirillales GM ATPases associated with a variety of cellular activities - - - ko:K09691 ko02010,map02010 M00250 - - ko00000,ko00001,ko00002,ko02000 3.A.1.103 - - ABC_tran k59_1348873_1 946077.W5A_05828 0.00049 48.1 COG0823@1|root,COG1228@1|root,COG0823@2|Bacteria,COG1228@2|Bacteria,4PM8I@976|Bacteroidetes,1HZ2Z@117743|Flavobacteriia 976|Bacteroidetes QU COG0823 Periplasmic component of the Tol biopolymer transport system - - - - - - - - - - - - Amidohydro_1,PD40 k59_164752_1 330214.NIDE0848 4.73e-87 262.0 COG0755@1|root,COG0755@2|Bacteria,3J0NY@40117|Nitrospirae 40117|Nitrospirae O Cytochrome C assembly protein - - - - - - - - - - - - Cytochrom_C_asm k59_280000_1 926559.JoomaDRAFT_1165 7.14e-112 342.0 COG0657@1|root,COG2755@1|root,COG0657@2|Bacteria,COG2755@2|Bacteria,4NKE5@976|Bacteroidetes,1HZ6S@117743|Flavobacteriia 976|Bacteroidetes E GDSL family lipase rhgT_1 - - - - - - - - - - - Lipase_GDSL_2,Polysacc_deac_1 k59_1523954_1 436308.Nmar_0771 4.33e-22 90.1 COG0163@1|root,arCOG01703@2157|Archaea,41SHU@651137|Thaumarchaeota 651137|Thaumarchaeota H Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN ubiX - 2.5.1.129 ko:K03186 ko00130,ko00627,ko00940,ko01100,ko01110,ko01120,ko01220,map00130,map00627,map00940,map01100,map01110,map01120,map01220 M00117 R01238,R02952,R03367,R04985,R04986,R11225 RC00391,RC00814,RC03392 ko00000,ko00001,ko00002,ko01000 - - - Flavoprotein k59_1009143_1 1230476.C207_01177 7.52e-14 71.6 2A4W6@1|root,302SA@2|Bacteria,1N3I3@1224|Proteobacteria,2UE78@28211|Alphaproteobacteria,3K0AC@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_671856_1 396588.Tgr7_2002 8.77e-104 315.0 COG2256@1|root,COG2256@2|Bacteria,1MUVS@1224|Proteobacteria,1RPBY@1236|Gammaproteobacteria,1WVV4@135613|Chromatiales 135613|Chromatiales L AAA ATPase, central domain protein - - - ko:K07478 - - - - ko00000 - - - AAA,AAA_assoc_2,MgsA_C,RuvB_N k59_620010_2 392499.Swit_4607 3.45e-30 116.0 COG0183@1|root,COG0183@2|Bacteria,1MUZV@1224|Proteobacteria,2TRHF@28211|Alphaproteobacteria,2K20B@204457|Sphingomonadales 204457|Sphingomonadales I acetyl-coa acetyltransferase - - - - - - - - - - - - - k59_733001_1 930166.CD58_25900 4.17e-15 77.8 COG0815@1|root,COG0815@2|Bacteria,1MUBU@1224|Proteobacteria,1RM8M@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Transfers the fatty acyl group on membrane lipoproteins lnt GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016021,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019538,GO:0031224,GO:0031226,GO:0034645,GO:0036211,GO:0042157,GO:0042158,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576 - ko:K03820 - - - - ko00000,ko01000 - GT2 iEcSMS35_1347.EcSMS35_0678,iSbBS512_1146.SbBS512_E0590 CN_hydrolase k59_1746475_1 439235.Dalk_0234 3.24e-31 120.0 COG3385@1|root,COG3385@2|Bacteria,1RCTP@1224|Proteobacteria,431NI@68525|delta/epsilon subdivisions,2WWWQ@28221|Deltaproteobacteria 28221|Deltaproteobacteria L PFAM Transposase DDE domain - - - - - - - - - - - - DDE_Tnp_1 k59_110408_1 522373.Smlt4652 3.33e-65 213.0 COG1262@1|root,COG1262@2|Bacteria,1MUNC@1224|Proteobacteria,1RQI4@1236|Gammaproteobacteria,1X38X@135614|Xanthomonadales 135614|Xanthomonadales S DinB superfamily - - - - - - - - - - - - DinB_2,FGE-sulfatase k59_1238078_1 316407.85676434 2.36e-165 467.0 COG0240@1|root,COG0240@2|Bacteria,1MUU3@1224|Proteobacteria,1RPQ7@1236|Gammaproteobacteria,3XNWW@561|Escherichia 1236|Gammaproteobacteria I Glycerol-3-phosphate dehydrogenase gpsA GO:0003674,GO:0003824,GO:0004367,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006072,GO:0006629,GO:0006644,GO:0006650,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0045017,GO:0046474,GO:0046486,GO:0047952,GO:0052646,GO:0055114,GO:0071704,GO:0090407,GO:1901135,GO:1901576 1.1.1.94 ko:K00057 ko00564,ko01110,map00564,map01110 - R00842,R00844 RC00029 ko00000,ko00001,ko01000 - - iJN746.PP_4169,iSFV_1184.SFV_3923 NAD_Gly3P_dh_C,NAD_Gly3P_dh_N k59_1689563_2 1122137.AQXF01000001_gene3147 2.04e-21 93.2 COG0642@1|root,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria 1224|Proteobacteria T Histidine kinase - - - - - - - - - - - - HATPase_c,HisKA,PAS_9,Response_reg k59_1462642_1 243159.AFE_1464 2.63e-33 129.0 COG0037@1|root,COG0037@2|Bacteria,1MU85@1224|Proteobacteria,1RN14@1236|Gammaproteobacteria,2NCJ8@225057|Acidithiobacillales 225057|Acidithiobacillales D Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine tilS - 6.3.4.19 ko:K04075 - - R09597 RC02633,RC02634 ko00000,ko01000,ko03016 - - - ATP_bind_3,TilS,TilS_C k59_1462642_2 76114.ebA4148 1.17e-64 209.0 COG0825@1|root,COG0825@2|Bacteria,1MURN@1224|Proteobacteria,2VHS0@28216|Betaproteobacteria,2KUDJ@206389|Rhodocyclales 206389|Rhodocyclales I Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA accA - 2.1.3.15,6.4.1.2 ko:K01962 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04386 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 - - - ACCA k59_1009161_2 98439.AJLL01000098_gene1942 1.14e-43 152.0 COG1064@1|root,COG1064@2|Bacteria,1G327@1117|Cyanobacteria,1JIY9@1189|Stigonemataceae 1117|Cyanobacteria S Alcohol dehydrogenase GroES-like domain - - 1.1.1.1 ko:K13953 ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220 - R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310 RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273 ko00000,ko00001,ko01000 - - - ADH_N,ADH_zinc_N k59_1581511_1 1232683.ADIMK_1599 3.94e-11 64.3 COG4942@1|root,COG4942@2|Bacteria,1RD24@1224|Proteobacteria,1RR11@1236|Gammaproteobacteria,466TP@72275|Alteromonadaceae 1236|Gammaproteobacteria D COG0739 Membrane proteins related to metalloendopeptidases nlpD GO:0000920,GO:0001896,GO:0005575,GO:0005623,GO:0008150,GO:0008219,GO:0009279,GO:0009987,GO:0012501,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0032153,GO:0042221,GO:0042493,GO:0043085,GO:0044093,GO:0044462,GO:0044464,GO:0050790,GO:0050896,GO:0051301,GO:0051336,GO:0051345,GO:0065007,GO:0065009,GO:0071944 - ko:K06194,ko:K12943 - - - - ko00000 1.A.34.1.2 - - LysM,Peptidase_M23 k59_1581511_2 305700.B447_01461 2.87e-32 116.0 COG1238@1|root,COG1238@2|Bacteria,1MWED@1224|Proteobacteria,2VT25@28216|Betaproteobacteria 28216|Betaproteobacteria S SNARE associated Golgi protein - - - - - - - - - - - - SNARE_assoc k59_164773_1 1234364.AMSF01000027_gene3496 2.59e-13 72.0 COG3164@1|root,COG3164@2|Bacteria,1MXWF@1224|Proteobacteria,1RNUK@1236|Gammaproteobacteria,1X37J@135614|Xanthomonadales 135614|Xanthomonadales S membrane - - - - - - - - - - - - AsmA_2,DUF3971 k59_164773_2 1163617.SCD_n01949 5.37e-31 118.0 COG0388@1|root,COG0388@2|Bacteria,1MUUB@1224|Proteobacteria,2VIR4@28216|Betaproteobacteria 28216|Betaproteobacteria S Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase opaA - 3.5.5.1 ko:K01501,ko:K11206 ko00380,ko00460,ko00627,ko00643,ko00910,ko01120,map00380,map00460,map00627,map00643,map00910,map01120 - R00540,R01887,R03093,R03542,R05591,R07855 RC00315,RC00325,RC00617,RC00959,RC02811 ko00000,ko00001,ko01000 - - - CN_hydrolase k59_1123579_1 1448139.AI20_06155 5.65e-37 132.0 COG0625@1|root,COG0625@2|Bacteria,1RA4Y@1224|Proteobacteria,1S2I8@1236|Gammaproteobacteria,1Y5R8@135624|Aeromonadales 135624|Aeromonadales G Glutathione S-transferase, C-terminal domain maiA - 5.2.1.4 ko:K01801 ko00350,ko01100,ko01120,map00350,map01100,map01120 - R03868 RC00867 ko00000,ko00001,ko01000 - - - GST_C_3,GST_N_3 k59_1123579_2 991905.SL003B_3061 2.49e-32 121.0 COG0179@1|root,COG0179@2|Bacteria,1MV0V@1224|Proteobacteria,2TQYU@28211|Alphaproteobacteria,4BPRW@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria Q Fumarylacetoacetate (FAA) hydrolase family - - 3.7.1.2 ko:K16171 ko00350,ko00643,ko01100,ko01120,map00350,map00643,map01100,map01120 M00044 R01364 RC00326,RC00446 ko00000,ko00001,ko00002,ko01000 - - - FAA_hydrolase k59_783255_1 983920.Y88_1203 2.5e-40 139.0 COG1028@1|root,COG1028@2|Bacteria,1MU6X@1224|Proteobacteria,2TQZG@28211|Alphaproteobacteria,2K1MK@204457|Sphingomonadales 204457|Sphingomonadales IQ COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) fabG - 1.1.1.100 ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 k59_783255_2 314225.ELI_07330 2.84e-15 74.3 COG0592@1|root,COG0592@2|Bacteria,1MVD9@1224|Proteobacteria,2TSRZ@28211|Alphaproteobacteria,2K052@204457|Sphingomonadales 204457|Sphingomonadales L Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria dnaN - 2.7.7.7 ko:K02338 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_beta,DNA_pol3_beta_2,DNA_pol3_beta_3 k59_1523990_1 1415779.JOMH01000001_gene454 8.4e-27 112.0 COG0463@1|root,COG0463@2|Bacteria,1QX0V@1224|Proteobacteria,1T32V@1236|Gammaproteobacteria,1X4VQ@135614|Xanthomonadales 135614|Xanthomonadales M glycosyl transferase family 2 - - - - - - - - - - - - Glyco_transf_7C,Glycos_transf_2 k59_110424_1 702113.PP1Y_AT34384 6.1e-69 222.0 COG1256@1|root,COG1256@2|Bacteria,1MV2M@1224|Proteobacteria,2U2HH@28211|Alphaproteobacteria,2K1JD@204457|Sphingomonadales 204457|Sphingomonadales N flagellar hook-associated protein flgK - - ko:K02396 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - Flg_bb_rod,Flg_bbr_C k59_1462670_1 702113.PP1Y_AT12050 1.74e-74 231.0 COG1451@1|root,COG1451@2|Bacteria,1MXZU@1224|Proteobacteria,2U1JG@28211|Alphaproteobacteria,2K287@204457|Sphingomonadales 204457|Sphingomonadales S Metal-dependent hydrolase - - - ko:K07043 - - - - ko00000 - - - DUF45 k59_953874_1 1122137.AQXF01000005_gene1359 3.81e-108 338.0 COG2182@1|root,COG2182@2|Bacteria,1MU3H@1224|Proteobacteria,2U0ZI@28211|Alphaproteobacteria 28211|Alphaproteobacteria G Extracellular solute-binding protein - - - - - - - - - - - - - k59_1581546_1 748727.CLJU_c41140 6.42e-33 120.0 COG0244@1|root,COG0244@2|Bacteria,1V3JJ@1239|Firmicutes,24G9R@186801|Clostridia,36I5W@31979|Clostridiaceae 186801|Clostridia J Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors rplJ - - ko:K02864 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L10 k59_733060_1 1123279.ATUS01000001_gene1427 4.38e-14 72.4 COG1226@1|root,COG4651@1|root,COG1226@2|Bacteria,COG4651@2|Bacteria,1MV34@1224|Proteobacteria,1RNH4@1236|Gammaproteobacteria,1J4J8@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family ybaL - - ko:K03455 - - - - ko00000 2.A.37 - - Na_H_Exchanger,TrkA_N k59_953878_1 1254432.SCE1572_29595 9.47e-31 131.0 COG0515@1|root,COG0642@1|root,COG0784@1|root,COG3899@1|root,COG0515@2|Bacteria,COG0784@2|Bacteria,COG2205@2|Bacteria,COG3899@2|Bacteria,1NRP8@1224|Proteobacteria,42M0Y@68525|delta/epsilon subdivisions,2X7MY@28221|Deltaproteobacteria,2YXD9@29|Myxococcales 28221|Deltaproteobacteria T Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - - - - - - - - - - AAA_16,GAF,GAF_2,HAMP,HATPase_c,HisKA,Pkinase,Response_reg k59_110451_1 634177.GLX_00630 2.02e-16 78.2 COG2801@1|root,COG2801@2|Bacteria,1R471@1224|Proteobacteria,2U60M@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Integrase core domain - - - - - - - - - - - - HTH_21,rve k59_110451_2 1120956.JHZK01000057_gene1843 3.51e-48 156.0 COG2963@1|root,COG2963@2|Bacteria,1N75X@1224|Proteobacteria,2UIVT@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Transposase and inactivated derivatives - - - - - - - - - - - - HTH_28 k59_1182407_2 1487953.JMKF01000008_gene6058 4.74e-17 80.1 COG3409@1|root,COG3409@2|Bacteria,1GB4I@1117|Cyanobacteria 1117|Cyanobacteria M Putative peptidoglycan binding domain - - - - - - - - - - - - PG_binding_1 k59_783291_1 69395.JQLZ01000005_gene3608 6.04e-08 54.7 COG2850@1|root,COG2850@2|Bacteria,1MUAC@1224|Proteobacteria,2TSG2@28211|Alphaproteobacteria,2KHVD@204458|Caulobacterales 204458|Caulobacterales S transcription factor jumonji - - - - - - - - - - - - Cupin_8 k59_783291_2 317013.NY99_05975 5.02e-42 145.0 28NZ4@1|root,2ZBW3@2|Bacteria,1QU1F@1224|Proteobacteria,1S49G@1236|Gammaproteobacteria,1X3QP@135614|Xanthomonadales 135614|Xanthomonadales S SapC - - - - - - - - - - - - SapC k59_1689639_1 589873.EP13_04240 1.72e-18 89.7 COG3063@1|root,COG3271@1|root,COG3063@2|Bacteria,COG3271@2|Bacteria,1RA3D@1224|Proteobacteria,1S2EC@1236|Gammaproteobacteria,4656G@72275|Alteromonadaceae 1236|Gammaproteobacteria NU Peptidase_C39 like family - - - - - - - - - - - - Peptidase_C39_2,TPR_16 k59_620100_1 194439.CT1683 1.17e-68 230.0 COG0474@1|root,COG0474@2|Bacteria 2|Bacteria P ATPase, P-type transporting, HAD superfamily, subfamily IC - - 3.6.3.2,3.6.3.6 ko:K01531,ko:K01535 ko00190,map00190 - - - ko00000,ko00001,ko01000 3.A.3.3,3.A.3.4 - - Cation_ATPase_N,E1-E2_ATPase,Hydrolase k59_1070713_1 1122137.AQXF01000002_gene590 8.54e-126 376.0 COG0471@1|root,COG0490@1|root,COG0471@2|Bacteria,COG0490@2|Bacteria,1MU0K@1224|Proteobacteria,2TSFS@28211|Alphaproteobacteria 28211|Alphaproteobacteria P COG0471 Di- and tricarboxylate transporters - - - - - - - - - - - - CitMHS,TrkA_C k59_337764_1 1121405.dsmv_1279 6.37e-106 329.0 COG3501@1|root,COG3501@2|Bacteria,1Q96K@1224|Proteobacteria,42RTE@68525|delta/epsilon subdivisions,2WNJ9@28221|Deltaproteobacteria,2MMJ0@213118|Desulfobacterales 28221|Deltaproteobacteria S Phage late control gene D protein (GPD) - - - - - - - - - - - - Phage_GPD,Phage_base_V k59_164847_1 1122137.AQXF01000007_gene3520 1e-191 540.0 COG1485@1|root,COG1485@2|Bacteria,1MUUW@1224|Proteobacteria,2TRG1@28211|Alphaproteobacteria 28211|Alphaproteobacteria E ATPase, AFG1 family zapE GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0006091,GO:0006119,GO:0006123,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006996,GO:0007005,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009060,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016020,GO:0016043,GO:0016310,GO:0017144,GO:0019538,GO:0019637,GO:0019646,GO:0019693,GO:0022900,GO:0022904,GO:0030163,GO:0031090,GO:0031966,GO:0031967,GO:0031975,GO:0034641,GO:0035694,GO:0042773,GO:0042775,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044281,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0045333,GO:0046034,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0071840,GO:0072521,GO:1901135,GO:1901360,GO:1901564,GO:1901565,GO:1901575 - ko:K06916 - - - - ko00000,ko03036 - - - AFG1_ATPase k59_280113_1 1122201.AUAZ01000040_gene3815 1.3e-27 115.0 COG0739@1|root,COG0739@2|Bacteria,1MVTF@1224|Proteobacteria,1RM7S@1236|Gammaproteobacteria,4640S@72275|Alteromonadaceae 1236|Gammaproteobacteria M COG0739 Membrane proteins related to metalloendopeptidases yebA - - - - - - - - - - - OapA,OapA_N,Peptidase_M23 k59_733091_1 316407.85676833 3.89e-153 447.0 COG1289@1|root,COG1289@2|Bacteria,1R0HK@1224|Proteobacteria,1RQSH@1236|Gammaproteobacteria,3XNXH@561|Escherichia 1236|Gammaproteobacteria U Could be involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride mdtO GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006855,GO:0008150,GO:0015238,GO:0015546,GO:0015893,GO:0015906,GO:0016020,GO:0022857,GO:0042221,GO:0042493,GO:0042886,GO:0042887,GO:0042891,GO:0042895,GO:0042908,GO:0042910,GO:0044464,GO:0045117,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0072348,GO:1901474,GO:1901682,GO:1902599 - ko:K15547 - - - - ko00000,ko02000 2.A.85.6.1 - - FUSC k59_903019_1 349521.HCH_05832 1.04e-22 102.0 COG0643@1|root,COG0745@1|root,COG2198@1|root,COG0643@2|Bacteria,COG0745@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,1RMS6@1236|Gammaproteobacteria,1XHMP@135619|Oceanospirillales 135619|Oceanospirillales T Chemotaxis protein histidine kinase and related - - - - - - - - - - - - CheW,HATPase_c,Hpt,Response_reg k59_1348951_1 492774.JQMB01000018_gene3591 2.57e-21 92.4 COG0730@1|root,COG0730@2|Bacteria,1MVBS@1224|Proteobacteria,2TQW0@28211|Alphaproteobacteria,4BB2E@82115|Rhizobiaceae 28211|Alphaproteobacteria S Sulfite exporter TauE/SafE - - - ko:K07090 - - - - ko00000 - - - TauE k59_620128_2 292.DM42_3553 2.63e-18 88.6 2FINS@1|root,34AEJ@2|Bacteria,1P36R@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_1182474_1 1121374.KB891576_gene661 2.25e-24 104.0 COG0492@1|root,COG0664@1|root,COG1142@1|root,COG0492@2|Bacteria,COG0664@2|Bacteria,COG1142@2|Bacteria,1QWC6@1224|Proteobacteria,1RPDJ@1236|Gammaproteobacteria 1236|Gammaproteobacteria C PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein hyfA - - ko:K12136 - - - - ko00000,ko01000 - - iEcolC_1368.EcolC_1195,iUMNK88_1353.UMNK88_3076 Fer4,Fer4_3,Fer4_4,Fer4_6,Fer4_7,Fer4_9,Pyr_redox_2,Pyr_redox_3,cNMP_binding k59_394857_1 351607.Acel_1054 3.47e-44 164.0 COG0587@1|root,COG0587@2|Bacteria,2GJ1P@201174|Actinobacteria,4ERD2@85013|Frankiales 201174|Actinobacteria L DNA polymerase III alpha subunit dnaE - 2.7.7.7 ko:K02337 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon k59_1634377_1 1229909.NSED_08115 0.000286 42.0 arCOG08684@1|root,arCOG08684@2157|Archaea,41T64@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1634377_2 1229909.NSED_02665 1.04e-77 232.0 COG0231@1|root,arCOG04277@2157|Archaea,41SNP@651137|Thaumarchaeota 651137|Thaumarchaeota J Functions by promoting the formation of the first peptide bond eif5a - - ko:K03263 - - - - ko00000,ko03012 - - - eIF-5a k59_1799005_1 1545915.JROG01000001_gene281 5.69e-10 58.5 COG3665@1|root,COG3665@2|Bacteria,1N2KR@1224|Proteobacteria,2TSBV@28211|Alphaproteobacteria,2K1Q9@204457|Sphingomonadales 204457|Sphingomonadales S Domain of unknown function (DUF1989) - - - ko:K09967 - - - - ko00000 - - - DUF1989 k59_1799005_2 1096930.L284_18525 1.27e-86 258.0 COG3665@1|root,COG3665@2|Bacteria,1N9DM@1224|Proteobacteria,2TU1Z@28211|Alphaproteobacteria,2K0UW@204457|Sphingomonadales 204457|Sphingomonadales S Domain of unknown function (DUF1989) - - - ko:K09967 - - - - ko00000 - - - DUF1989 k59_903033_1 156889.Mmc1_3679 1.54e-98 306.0 COG3572@1|root,COG3572@2|Bacteria,1MU47@1224|Proteobacteria,2TRPT@28211|Alphaproteobacteria 28211|Alphaproteobacteria H glutamate--cysteine ligase gshA - 6.3.2.2 ko:K01919 ko00270,ko00480,ko01100,map00270,map00480,map01100 M00118 R00894,R10993 RC00064,RC00090 ko00000,ko00001,ko00002,ko01000 - - - GCS2 k59_903033_2 69014.TK1747 1.31e-17 83.6 COG1986@1|root,arCOG01221@2157|Archaea,2XWMP@28890|Euryarchaeota,2442B@183968|Thermococci 183968|Thermococci F Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions - GO:0003674,GO:0003824,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111 - - - - - - - - - - NTPase_I-T k59_1634381_1 702113.PP1Y_AT5753 1.22e-17 87.4 COG3391@1|root,COG3391@2|Bacteria,1P862@1224|Proteobacteria,2TR6Z@28211|Alphaproteobacteria,2K2W8@204457|Sphingomonadales 204457|Sphingomonadales S Lactonase, 7-bladed beta-propeller - - - - - - - - - - - - Cytochrom_D1,Lactonase,PQQ_2 k59_733109_1 247634.GPB2148_2367 9.11e-11 62.0 COG1995@1|root,COG1995@2|Bacteria,1MX5W@1224|Proteobacteria,1RNZV@1236|Gammaproteobacteria,1J4GJ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) pdxA GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006081,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008614,GO:0008615,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0034641,GO:0036094,GO:0042364,GO:0042802,GO:0042816,GO:0042819,GO:0042822,GO:0042823,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046184,GO:0046483,GO:0046872,GO:0046914,GO:0048037,GO:0050570,GO:0050662,GO:0051186,GO:0051188,GO:0051287,GO:0055114,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 1.1.1.262 ko:K00097 ko00750,ko01100,map00750,map01100 M00124 R05681,R05837,R07406 RC00089,RC00675,RC01475 ko00000,ko00001,ko00002,ko01000 - - iECO111_1330.ECO111_0056 PdxA k59_1294015_1 552396.HMPREF0863_01834 6.4e-57 193.0 COG4670@1|root,COG4670@2|Bacteria,1TP5H@1239|Firmicutes,3VPRN@526524|Erysipelotrichia 526524|Erysipelotrichia I Psort location Cytoplasmic, score 8.87 - - - - - - - - - - - - CoA_trans k59_1349971_1 1121878.AUGL01000009_gene3394 1.64e-21 95.5 COG0500@1|root,COG2226@2|Bacteria,1QTWC@1224|Proteobacteria,1RS4G@1236|Gammaproteobacteria 1236|Gammaproteobacteria Q Methyl-transferase yafS - - - - - - - - - - - Methyltransf_11 k59_501870_1 987059.RBXJA2T_06430 2.22e-43 151.0 COG0331@1|root,COG0331@2|Bacteria,1MV6N@1224|Proteobacteria,2VJF7@28216|Betaproteobacteria,1KJRI@119065|unclassified Burkholderiales 28216|Betaproteobacteria I malonyl CoA-acyl carrier protein transacylase fabD - 2.3.1.39 ko:K00645,ko:K15355 ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212 M00082 R01626,R11671 RC00004,RC00039,RC02727 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Acyl_transf_1 k59_501870_2 1348657.M622_02375 7.49e-26 103.0 COG0332@1|root,COG0332@2|Bacteria,1MU9N@1224|Proteobacteria,2VI2A@28216|Betaproteobacteria,2KUAG@206389|Rhodocyclales 206389|Rhodocyclales I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids fabH - 2.3.1.180 ko:K00648 ko00061,ko01100,ko01212,map00061,map01100,map01212 M00082,M00083 R10707 RC00004,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - ACP_syn_III,ACP_syn_III_C k59_843953_1 1002339.HMPREF9373_1676 2.98e-78 262.0 COG1040@1|root,COG1040@2|Bacteria,1QV41@1224|Proteobacteria,1RSAP@1236|Gammaproteobacteria,3NM26@468|Moraxellaceae 1236|Gammaproteobacteria K acetyltransferase - - - - - - - - - - - - - k59_223071_1 243233.MCA1857 1.15e-46 158.0 COG0576@1|root,COG0576@2|Bacteria,1RH8T@1224|Proteobacteria,1S5W5@1236|Gammaproteobacteria,1XF1X@135618|Methylococcales 135618|Methylococcales O Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ grpE - - ko:K03687 - - - - ko00000,ko03029,ko03110 - - - GrpE k59_446776_1 1229909.NSED_09565 2.05e-77 236.0 COG4221@1|root,arCOG01265@2157|Archaea,41S66@651137|Thaumarchaeota 651137|Thaumarchaeota I Belongs to the short-chain dehydrogenases reductases (SDR) family - - - - - - - - - - - - adh_short k59_1010367_1 717774.Marme_1736 1.41e-13 75.5 COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,1RMP5@1236|Gammaproteobacteria,1XJAR@135619|Oceanospirillales 135619|Oceanospirillales MU PFAM Outer membrane efflux protein - - - - - - - - - - - - OEP k59_223084_1 69395.JQLZ01000001_gene3137 1.9e-99 316.0 COG1501@1|root,COG1501@2|Bacteria,1MWNJ@1224|Proteobacteria,2U1U0@28211|Alphaproteobacteria,2KI71@204458|Caulobacterales 204458|Caulobacterales G Belongs to the glycosyl hydrolase 31 family - - 3.2.1.177 ko:K01811 - - - - ko00000,ko01000 - GH31 - DUF4968,DUF5110,Glyco_hydro_31,PA14 k59_55638_1 756272.Plabr_2883 1.28e-62 201.0 COG0515@1|root,COG0515@2|Bacteria,2J2D5@203682|Planctomycetes 203682|Planctomycetes KLT Protein tyrosine kinase - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase k59_1183461_1 1157708.KB907450_gene6083 2.62e-29 105.0 COG2924@1|root,COG2924@2|Bacteria,1MZ2V@1224|Proteobacteria,2VTYU@28216|Betaproteobacteria,4AEC5@80864|Comamonadaceae 28216|Betaproteobacteria CO Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes yggX - - - - - - - - - - - Iron_traffic k59_1183461_2 292415.Tbd_0152 2.6e-34 132.0 COG3829@1|root,COG5001@1|root,COG5002@1|root,COG3829@2|Bacteria,COG5001@2|Bacteria,COG5002@2|Bacteria,1MU2C@1224|Proteobacteria,2VJMN@28216|Betaproteobacteria 28216|Betaproteobacteria T Diguanylate cyclase - - - - - - - - - - - - 7TMR-DISM_7TM,EAL,GGDEF,HAMP,MASE1,PAS_3,PAS_4,PAS_8,PAS_9 k59_1747571_1 1229909.NSED_06185 9.46e-135 396.0 COG1530@1|root,arCOG00321@2157|Archaea,41T2C@651137|Thaumarchaeota 651137|Thaumarchaeota L modulator of DNA gyrase - - - ko:K03568 - - - - ko00000,ko01002 - - - PmbA_TldD k59_843977_1 644801.Psest_2619 7.6e-42 152.0 COG4962@1|root,COG4962@2|Bacteria,1R7EN@1224|Proteobacteria,1RP9G@1236|Gammaproteobacteria,1Z180@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria U pilus assembly protein, ATPase CpaF tadA - - ko:K02283 - - - - ko00000,ko02035,ko02044 - - - T2SSE k59_1800004_1 1123519.PSJM300_17300 8.99e-26 112.0 2C2C7@1|root,2Z85G@2|Bacteria,1PD07@1224|Proteobacteria,1RP6G@1236|Gammaproteobacteria,1Z099@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_905838_1 1096930.L284_20495 1.6e-74 229.0 COG4149@1|root,COG4149@2|Bacteria,1MUXR@1224|Proteobacteria,2TSYJ@28211|Alphaproteobacteria,2K0AD@204457|Sphingomonadales 204457|Sphingomonadales P Molybdate modB - - ko:K02018 ko02010,map02010 M00189 - - ko00000,ko00001,ko00002,ko02000 3.A.1.8 - - BPD_transp_1 k59_680040_1 436308.Nmar_0748 2.61e-159 466.0 COG0480@1|root,arCOG01559@2157|Archaea,41S9B@651137|Thaumarchaeota 651137|Thaumarchaeota J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome fusA - - ko:K03234 ko04152,ko04921,map04152,map04921 - - - ko00000,ko00001,ko03012,ko04147 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2 k59_1019275_1 946077.W5A_01655 3.3e-64 196.0 COG2151@1|root,COG2151@2|Bacteria,4NSA9@976|Bacteroidetes,1I2WQ@117743|Flavobacteriia 976|Bacteroidetes S FeS assembly SUF system protein yitW - - - - - - - - - - - FeS_assembly_P k59_1019275_2 1042376.AFPK01000024_gene1374 3.59e-53 171.0 28NIX@1|root,2ZBK6@2|Bacteria,4NMEI@976|Bacteroidetes,1I1A5@117743|Flavobacteriia,406EK@61432|unclassified Flavobacteriaceae 976|Bacteroidetes S Protein of unknown function (DUF2480) - - - - - - - - - - - - DUF2480 k59_962532_1 1122225.AULQ01000003_gene837 1.72e-165 491.0 COG1629@1|root,COG4771@2|Bacteria,4NFAM@976|Bacteroidetes,1HWUQ@117743|Flavobacteriia 976|Bacteroidetes P TonB-dependent receptor - - - - - - - - - - - - CarbopepD_reg_2,Plug,TonB_dep_Rec k59_680043_1 1219045.BV98_000192 6.26e-13 70.9 COG5297@1|root,COG5297@2|Bacteria,1MV16@1224|Proteobacteria,2U0VE@28211|Alphaproteobacteria,2KEAF@204457|Sphingomonadales 204457|Sphingomonadales G Protein of unknown function (DUF1595) - - - - - - - - - - - - PSCyt3,PSD2,PSD3,PSD4,PSD5 k59_510510_2 66869.JNXG01000020_gene3430 1.55e-17 82.0 COG1201@1|root,COG1201@2|Bacteria,2GJG3@201174|Actinobacteria,418CE@629295|Streptomyces griseus group 201174|Actinobacteria L DEAD/H associated lhr - - ko:K03724 - - - - ko00000,ko01000,ko03400 - - - DEAD,DEAD_assoc,HTH_42,Helicase_C k59_397675_1 1197477.IA57_03135 2.52e-123 357.0 COG1600@1|root,COG1600@2|Bacteria,4NFCJ@976|Bacteroidetes,1HWPH@117743|Flavobacteriia 976|Bacteroidetes C Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) queG - 1.17.99.6 ko:K18979 - - - - ko00000,ko01000,ko03016 - - - DUF1730,Fer4_16 k59_623578_1 1123253.AUBD01000002_gene1215 2.03e-95 283.0 COG0692@1|root,COG0692@2|Bacteria,1MV80@1224|Proteobacteria,1RPDH@1236|Gammaproteobacteria,1X376@135614|Xanthomonadales 135614|Xanthomonadales L Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine ung GO:0003674,GO:0003824,GO:0004844,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006285,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097506,GO:0097510,GO:0140097,GO:1901360 3.2.2.27 ko:K03648 ko03410,ko05340,map03410,map05340 - - - ko00000,ko00001,ko01000,ko03400 - - - UDG k59_849622_1 1278309.KB907100_gene2164 1.34e-63 214.0 COG1200@1|root,COG1200@2|Bacteria,1MWN2@1224|Proteobacteria,1RMMQ@1236|Gammaproteobacteria,1XIN2@135619|Oceanospirillales 135619|Oceanospirillales L Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) recG - 3.6.4.12 ko:K03655 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,Helicase_C,RecG_wedge k59_115418_1 856793.MICA_936 5.11e-23 97.4 COG1565@1|root,COG1565@2|Bacteria,1N3CJ@1224|Proteobacteria,2TRHW@28211|Alphaproteobacteria,4BQ8C@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria S Putative S-adenosyl-L-methionine-dependent methyltransferase MA20_05390 - 2.1.1.79 ko:K00574,ko:K18164 ko04714,map04714 - - - ko00000,ko00001,ko01000,ko03029 - - - Methyltransf_28 k59_115418_2 1122137.AQXF01000003_gene2024 9.37e-75 231.0 COG0682@1|root,COG0682@2|Bacteria,1MVE3@1224|Proteobacteria,2TTNS@28211|Alphaproteobacteria 28211|Alphaproteobacteria M Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins lgt - - ko:K13292 - - - - ko00000,ko01000 - - - LGT k59_680049_1 1297865.APJD01000006_gene4608 3.27e-37 141.0 COG1331@1|root,COG1331@2|Bacteria,1MUUT@1224|Proteobacteria,2TV0X@28211|Alphaproteobacteria,3JXPF@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria O Protein of unknown function, DUF255 - - - ko:K06888 - - - - ko00000 - - - GlcNAc_2-epim,Thioredox_DsbH k59_510512_1 558169.AGAV01000019_gene3090 4.01e-10 67.4 COG0737@1|root,COG2374@1|root,COG0737@2|Bacteria,COG2374@2|Bacteria,1TPV2@1239|Firmicutes,4H9VJ@91061|Bacilli 91061|Bacilli F Belongs to the 5'-nucleotidase family cpdB - 3.1.3.5,3.1.3.6,3.1.4.16,3.6.1.45 ko:K01081,ko:K08693,ko:K11751 ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110 - R00183,R00511,R00963,R01126,R01227,R01562,R01569,R01664,R01877,R01968,R02088,R02102,R02148,R02323,R02370,R02719,R03346,R03537,R03538,R03929,R05135 RC00017,RC00078,RC00296 ko00000,ko00001,ko01000 - - - 5_nucleotid_C,CHB_HEX_C_1,Gram_pos_anchor,LTD,Metallophos,SLH k59_1132029_1 43989.cce_2016 8.36e-106 327.0 COG0365@1|root,COG0365@2|Bacteria,1G0E7@1117|Cyanobacteria,3KHAK@43988|Cyanothece 1117|Cyanobacteria H Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA acsA - 6.2.1.1 ko:K01895 ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200 M00357 R00235,R00236,R00316,R00926,R01354 RC00004,RC00012,RC00043,RC00070,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000,ko01004 - - - ACAS_N,AMP-binding,AMP-binding_C k59_736822_1 545264.KB898749_gene28 1.4e-22 92.0 COG1765@1|root,COG1765@2|Bacteria,1MWPR@1224|Proteobacteria,1S7W4@1236|Gammaproteobacteria 1236|Gammaproteobacteria O OsmC-like protein - - - - - - - - - - - - OsmC k59_736822_2 59538.XP_005960404.1 3.55e-51 171.0 COG1028@1|root,KOG1208@2759|Eukaryota,38CZD@33154|Opisthokonta,3BACQ@33208|Metazoa,3CSEJ@33213|Bilateria,481SB@7711|Chordata,495Q4@7742|Vertebrata,3J5ED@40674|Mammalia,4J08P@91561|Cetartiodactyla 33208|Metazoa Q retinol dehydrogenase 14 - - - ko:K11162,ko:K11168 - - - - ko00000,ko01000 - - - adh_short k59_1527510_1 1122137.AQXF01000002_gene85 2.38e-134 389.0 COG1703@1|root,COG1703@2|Bacteria,1MVI0@1224|Proteobacteria,2TS96@28211|Alphaproteobacteria 28211|Alphaproteobacteria E periplasmic protein kinase ArgK and related GTPases of G3E family argK - - ko:K07588 - - - - ko00000,ko01000 - - - ArgK k59_1471081_1 1385515.N791_06865 2.72e-31 126.0 COG4805@1|root,COG4805@2|Bacteria,1MUBX@1224|Proteobacteria,1RMT7@1236|Gammaproteobacteria,1X39Z@135614|Xanthomonadales 135614|Xanthomonadales S protein conserved in bacteria - - - - - - - - - - - - DUF885 k59_228068_1 136273.GY22_00925 4.18e-53 180.0 COG2133@1|root,COG2133@2|Bacteria,2GISM@201174|Actinobacteria,1W83Y@1268|Micrococcaceae 201174|Actinobacteria G Glucose / Sorbosone dehydrogenase gcd - - - - - - - - - - - GSDH k59_58885_1 1122137.AQXF01000003_gene2075 1.9e-125 373.0 COG1362@1|root,COG1362@2|Bacteria,1NT1D@1224|Proteobacteria 1224|Proteobacteria E M18 family aminopeptidase apeA - - - - - - - - - - - Peptidase_M18 k59_2098_1 204773.HEAR2381 4.76e-56 188.0 COG0845@1|root,COG0845@2|Bacteria,1MU78@1224|Proteobacteria,2VINC@28216|Betaproteobacteria,47353@75682|Oxalobacteraceae 28216|Betaproteobacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family acrA - - ko:K03585,ko:K18321 ko01501,ko01503,ko02020,map01501,map01503,map02020 M00645,M00646,M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000,ko03036 2.A.6.2,2.A.6.2.41,8.A.1,8.A.1.6 - - Biotin_lipoyl_2,HlyD_D23 k59_228072_1 436308.Nmar_1573 3.27e-123 364.0 COG0519@1|root,arCOG00085@2157|Archaea,41SDI@651137|Thaumarchaeota 651137|Thaumarchaeota F Catalyzes the synthesis of GMP from XMP guaA - 6.3.5.2 ko:K01951 ko00230,ko00983,ko01100,map00230,map00983,map01100 M00050 R01230,R01231,R08244 RC00010,RC00204 ko00000,ko00001,ko00002,ko01000,ko01002 - - - GATase,GMP_synt_C,NAD_synthase k59_58886_1 861299.J421_1816 1.98e-90 290.0 COG0574@1|root,COG3848@1|root,COG0574@2|Bacteria,COG3848@2|Bacteria 2|Bacteria GT kinase activity ppsA - 2.7.9.2 ko:K01007 ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200 M00173,M00374 R00199 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - PEP-utilizers,PPDK_N k59_1358127_1 649831.L083_0376 1.42e-06 51.2 2BAD0@1|root,323TF@2|Bacteria,2H8IH@201174|Actinobacteria,4DJY8@85008|Micromonosporales 201174|Actinobacteria - - - - - - - - - - - - - - - k59_228075_2 1232410.KI421422_gene2074 6.99e-58 206.0 COG0642@1|root,COG0834@1|root,COG0834@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,42RWK@68525|delta/epsilon subdivisions,2WNCS@28221|Deltaproteobacteria,43SHW@69541|Desulfuromonadales 28221|Deltaproteobacteria T Domains REC, HisKA, HATPase_c - - - - - - - - - - - - GAF,HATPase_c,HisKA,PAS_4,PAS_9,Response_reg k59_793245_2 644548.SCNU_19462 1.38e-130 383.0 COG0842@1|root,COG0842@2|Bacteria,2GJ7Y@201174|Actinobacteria,4GCQ2@85026|Gordoniaceae 201174|Actinobacteria U ABC-2 family transporter protein - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane,ABC2_membrane_3 k59_793245_3 1454010.JEOE01000004_gene69 1.22e-88 271.0 COG1131@1|root,COG1131@2|Bacteria,2IH64@201174|Actinobacteria,4F2FJ@85016|Cellulomonadaceae 201174|Actinobacteria V ATPases associated with a variety of cellular activities - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_793245_4 1108045.GORHZ_060_00190 2.97e-92 281.0 COG1131@1|root,COG1131@2|Bacteria,2ICIF@201174|Actinobacteria,4GGY6@85026|Gordoniaceae 201174|Actinobacteria V AAA domain, putative AbiEii toxin, Type IV TA system - - - ko:K01990,ko:K13926 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_1132037_1 1304275.C41B8_08770 4.06e-140 424.0 COG0525@1|root,COG0525@2|Bacteria,1MV7B@1224|Proteobacteria,1RNEB@1236|Gammaproteobacteria 1236|Gammaproteobacteria J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner valS GO:0000287,GO:0002161,GO:0003674,GO:0003824,GO:0004812,GO:0004832,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006417,GO:0006418,GO:0006438,GO:0006450,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0016070,GO:0016787,GO:0016788,GO:0016874,GO:0016875,GO:0019222,GO:0019538,GO:0019752,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0034248,GO:0034250,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045727,GO:0045903,GO:0046483,GO:0046872,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0052689,GO:0060255,GO:0061475,GO:0065007,GO:0065008,GO:0071704,GO:0080090,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:2000112 6.1.1.9 ko:K01873 ko00970,map00970 M00359,M00360 R03665 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iECH74115_1262.ECH74115_5779,iECNA114_1301.ECNA114_4481,iECO26_1355.ECO26_5428,iECSP_1301.ECSP_5359,iECs_1301.ECs5235,iG2583_1286.G2583_5088,iJN746.PP_0977,iSBO_1134.SBO_4182,iSSON_1240.SSON_4443,iYL1228.KPN_04663,iZ_1308.Z5870 Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1 k59_1188565_2 760154.Sulba_0439 1.17e-59 197.0 COG2009@1|root,2ZBTX@2|Bacteria,1RB22@1224|Proteobacteria,42NAY@68525|delta/epsilon subdivisions,2YMAV@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C fumarate reductase frdC - - ko:K00246 ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020 M00009,M00011,M00150,M00173 R02164 RC00045 ko00000,ko00001,ko00002 - - - Sdh_cyt k59_1527528_1 533247.CRD_00369 1.05e-09 63.2 COG2197@1|root,COG2197@2|Bacteria,1FZXR@1117|Cyanobacteria,1HJ9P@1161|Nostocales 1117|Cyanobacteria K response regulator, receiver - - - - - - - - - - - - GerE,Response_reg k59_793248_2 1229909.NSED_09170 2.93e-137 395.0 COG0500@1|root,arCOG04347@2157|Archaea,41T35@651137|Thaumarchaeota 651137|Thaumarchaeota Q Nodulation protein S (NodS) - - - - - - - - - - - - - k59_793248_4 436308.Nmar_1721 3.14e-94 288.0 COG0452@1|root,arCOG01704@2157|Archaea,41SYG@651137|Thaumarchaeota 651137|Thaumarchaeota H Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine - - 4.1.1.36,6.3.2.5 ko:K13038 ko00770,ko01100,map00770,map01100 M00120 R03269,R04231 RC00064,RC00090,RC00822 ko00000,ko00001,ko00002,ko01000 - - - DFP,Flavoprotein k59_1245200_1 1120951.AUBG01000014_gene3147 2.05e-35 133.0 COG0514@1|root,COG0514@2|Bacteria,4NEB4@976|Bacteroidetes,1HXCJ@117743|Flavobacteriia 976|Bacteroidetes L ATP-dependent DNA helicase RecQ recQ - 3.6.4.12 ko:K03654 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,HRDC,Helicase_C,RQC,RecQ_Zn_bind k59_1245200_2 1121912.AUHD01000001_gene2616 1.62e-22 95.1 COG0517@1|root,COG0794@1|root,COG0517@2|Bacteria,COG0794@2|Bacteria,4NED8@976|Bacteroidetes,1HXYH@117743|Flavobacteriia 976|Bacteroidetes M Belongs to the SIS family. GutQ KpsF subfamily kdsD - 5.3.1.13 ko:K06041 ko00540,ko01100,map00540,map01100 M00063 R01530 RC00541 ko00000,ko00001,ko00002,ko01000,ko01005 - - - CBS,SIS k59_1245206_1 1122137.AQXF01000005_gene1074 1.62e-54 179.0 COG0500@1|root,COG0640@1|root,COG0640@2|Bacteria,COG2226@2|Bacteria,1NFSV@1224|Proteobacteria,2TSMV@28211|Alphaproteobacteria 28211|Alphaproteobacteria KQ arsR family arsR - - - - - - - - - - - HTH_20,HTH_5,Methyltransf_11,Methyltransf_31 k59_962563_2 107635.AZUO01000001_gene1173 1.17e-09 60.5 COG3220@1|root,COG3220@2|Bacteria,1MURE@1224|Proteobacteria,2TRZJ@28211|Alphaproteobacteria,36ZBD@31993|Methylocystaceae 28211|Alphaproteobacteria S Protein of unknown function (DUF692) - - - ko:K09930 - - - - ko00000 - - - DUF692 k59_1640594_1 946077.W5A_01750 1.22e-15 75.9 COG2755@1|root,COG2755@2|Bacteria,4NGTK@976|Bacteroidetes,1HY1A@117743|Flavobacteriia 976|Bacteroidetes E G-D-S-L family lipolytic protein - - - - - - - - - - - - Lipase_GDSL k59_1640594_2 946077.W5A_01755 1.11e-119 367.0 COG1629@1|root,COG1629@2|Bacteria,COG4771@2|Bacteria,4NDX3@976|Bacteroidetes,1HY9Q@117743|Flavobacteriia 976|Bacteroidetes P TonB-dependent receptor - - - - - - - - - - - - CarbopepD_reg_2,Plug,TonB_dep_Rec k59_1302752_2 436308.Nmar_1388 4.82e-59 197.0 COG1032@1|root,arCOG01357@2157|Archaea,41SCX@651137|Thaumarchaeota 651137|Thaumarchaeota C Radical SAM - - - - - - - - - - - - Radical_SAM k59_1076320_1 1219035.NT2_04_00790 1.59e-115 343.0 COG0312@1|root,COG0312@2|Bacteria,1MUSK@1224|Proteobacteria,2TRSR@28211|Alphaproteobacteria,2JZY8@204457|Sphingomonadales 204457|Sphingomonadales S peptidase U62, modulator of DNA gyrase tldD - - ko:K03568 - - - - ko00000,ko01002 - - - PmbA_TldD k59_398768_1 316407.21321931 3.44e-17 75.1 COG2967@1|root,COG2967@2|Bacteria,1MZ2Z@1224|Proteobacteria,1S8SE@1236|Gammaproteobacteria,3XPM5@561|Escherichia 1236|Gammaproteobacteria P ApaG domain apaG - - ko:K06195 - - - - ko00000 - - - DUF525 k59_398768_2 316407.85674303 2.6e-99 293.0 COG0030@1|root,COG0030@2|Bacteria,1MVNU@1224|Proteobacteria,1RMHW@1236|Gammaproteobacteria,3XMDQ@561|Escherichia 1236|Gammaproteobacteria J Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits ksgA GO:0000028,GO:0000154,GO:0000179,GO:0001510,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003723,GO:0003729,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016072,GO:0016433,GO:0016740,GO:0016741,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0031167,GO:0032259,GO:0034470,GO:0034622,GO:0034641,GO:0034660,GO:0042254,GO:0042255,GO:0042274,GO:0043170,GO:0043412,GO:0043414,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0065003,GO:0070475,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0097159,GO:0140098,GO:0140102,GO:1901360,GO:1901363 2.1.1.182 ko:K02528 - - R10716 RC00003,RC03257 ko00000,ko01000,ko03009 - - - RrnaAD k59_1189573_1 436308.Nmar_0495 1.03e-167 478.0 COG0719@1|root,arCOG01715@2157|Archaea,41S5W@651137|Thaumarchaeota 651137|Thaumarchaeota O FeS assembly protein SufB - - - ko:K09014 - - - - ko00000 - - - UPF0051 k59_1189573_2 1229909.NSED_02485 3.54e-45 158.0 COG0719@1|root,arCOG01715@2157|Archaea,41S7W@651137|Thaumarchaeota 651137|Thaumarchaeota O FeS assembly protein SufD - - - ko:K09014,ko:K09015 - - - - ko00000 - - - UPF0051 k59_1472113_1 768671.ThimaDRAFT_3410 4.01e-25 99.8 COG3088@1|root,COG3088@2|Bacteria,1MZZ5@1224|Proteobacteria,1S9DV@1236|Gammaproteobacteria,1WY4S@135613|Chromatiales 135613|Chromatiales P subunit of a heme lyase - - - ko:K02200 - - - - ko00000 - - - CcmH k59_1076329_1 2002.JOEQ01000031_gene1648 1.46e-18 79.0 COG1977@1|root,COG1977@2|Bacteria,2IQJJ@201174|Actinobacteria,4EPKG@85012|Streptosporangiales 201174|Actinobacteria H Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin - - - - - - - - - - - - ThiS k59_1076329_2 1123392.AQWL01000005_gene3016 2.91e-60 195.0 COG4447@1|root,COG4447@2|Bacteria,1ND1J@1224|Proteobacteria,2VMA5@28216|Betaproteobacteria,1KTCE@119069|Hydrogenophilales 119069|Hydrogenophilales S protein related to plant photosystem II stability assembly factor - - - - - - - - - - - - - k59_1189590_1 2074.JNYD01000019_gene2436 7.39e-35 130.0 2BGH6@1|root,32AF9@2|Bacteria,2IR8N@201174|Actinobacteria,4EBCX@85010|Pseudonocardiales 201174|Actinobacteria S SnoaL-like domain - - - - - - - - - - - - SnoaL_2 k59_1246256_2 436308.Nmar_0944 3.61e-140 410.0 COG1111@1|root,arCOG00872@2157|Archaea 2157|Archaea L DEAD DEAH box helicase domain protein - - - ko:K03703,ko:K10896 ko03420,ko03460,map03420,map03460 M00413 - - ko00000,ko00001,ko00002,ko03400 - - - DEAD,ERCC4,HHH_2,HHH_5,Helicase_C,ResIII k59_3193_1 357804.Ping_0979 1.36e-15 81.6 COG0642@1|root,COG0784@1|root,COG0834@1|root,COG2198@1|root,COG0784@2|Bacteria,COG0834@2|Bacteria,COG2198@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,1SKTW@1236|Gammaproteobacteria,2QIRM@267894|Psychromonadaceae 1236|Gammaproteobacteria T ATP-binding region, ATPase domain protein domain protein - - 2.7.13.3 ko:K10715,ko:K20974 ko02020,ko02024,ko02025,map02020,map02024,map02025 M00517,M00820 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - CHASE,DUF4118,GAF_2,HATPase_c,HisKA,Hpt,PAS,PAS_3,PAS_4,PAS_9,Response_reg k59_738033_1 1122137.AQXF01000002_gene69 6.35e-24 94.7 COG0781@1|root,COG0781@2|Bacteria,1RHFZ@1224|Proteobacteria,2UBQA@28211|Alphaproteobacteria 28211|Alphaproteobacteria K Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons nusB - - ko:K03625 - - - - ko00000,ko03009,ko03021 - - - NusB k59_738033_2 1122137.AQXF01000002_gene68 1.64e-80 241.0 COG0054@1|root,COG0054@2|Bacteria,1RD9J@1224|Proteobacteria,2U9IZ@28211|Alphaproteobacteria 28211|Alphaproteobacteria H Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin ribH GO:0000906,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.78 ko:K00794 ko00740,ko01100,ko01110,map00740,map01100,map01110 M00125 R04457 RC00960 ko00000,ko00001,ko00002,ko01000 - - - DMRL_synthase k59_794360_1 156889.Mmc1_1921 7.91e-97 307.0 COG0515@1|root,COG1262@1|root,COG3170@1|root,COG0515@2|Bacteria,COG1262@2|Bacteria,COG3170@2|Bacteria,1PJRR@1224|Proteobacteria,2U625@28211|Alphaproteobacteria 28211|Alphaproteobacteria KLT serine threonine protein kinase - - 2.7.11.1 ko:K08282 - - - - ko00000,ko01000 - - - DUF4189,PG_binding_1,Pkinase,WD40 k59_342462_1 1565129.JSFF01000021_gene625 2.42e-06 53.5 COG0784@1|root,COG5002@1|root,COG0784@2|Bacteria,COG5002@2|Bacteria,1NC9X@1224|Proteobacteria,1RWU0@1236|Gammaproteobacteria,2QDII@267890|Shewanellaceae 1236|Gammaproteobacteria T Histidine Phosphotransfer domain - - - - - - - - - - - - HATPase_c,HisKA,Hpt,PAS,Response_reg,dCache_1 k59_342462_2 498211.CJA_3209 1.08e-20 91.7 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,1FGP3@10|Cellvibrio 1236|Gammaproteobacteria T Bacterial regulatory protein, Fis family pilR - - ko:K02481,ko:K02667 ko02020,map02020 M00501 - - ko00000,ko00001,ko00002,ko02022,ko02035 - - - HTH_8,Response_reg,Sigma54_activat k59_1246260_1 1380355.JNIJ01000041_gene5229 2.84e-78 256.0 COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,2TR8H@28211|Alphaproteobacteria,3JUGA@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria C Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain lpdA - 1.8.1.4 ko:K00382 ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00036,M00307,M00532 R00209,R01221,R01698,R03815,R07618,R08549 RC00004,RC00022,RC00583,RC02742,RC02833,RC02834 br01601,ko00000,ko00001,ko00002,ko01000,ko04147 - - - Biotin_lipoyl,Pyr_redox_2,Pyr_redox_dim k59_1189599_1 1040983.AXAE01000013_gene5633 1.39e-07 54.3 COG5267@1|root,COG5267@2|Bacteria,1MWJK@1224|Proteobacteria,2TSY7@28211|Alphaproteobacteria,43MWR@69277|Phyllobacteriaceae 28211|Alphaproteobacteria S Protein of unknown function (DUF1800) - - - - - - - - - - - - DUF1800 k59_1189599_2 579405.Dd703_3443 1.97e-37 139.0 COG4102@1|root,COG4102@2|Bacteria,1MX4R@1224|Proteobacteria,1RP7V@1236|Gammaproteobacteria 1236|Gammaproteobacteria S protein conserved in bacteria - - - - - - - - - - - - DUF1501 k59_963576_2 1125863.JAFN01000001_gene3389 2.53e-37 138.0 COG3303@1|root,COG3303@2|Bacteria,1QX6Q@1224|Proteobacteria,42MHA@68525|delta/epsilon subdivisions,2WMF3@28221|Deltaproteobacteria 28221|Deltaproteobacteria P Cytochrome c554 and c-prime - - - - - - - - - - - - Cytochrom_C552,Cytochrome_C554,Paired_CXXCH_1 k59_568313_1 1485544.JQKP01000003_gene275 1.77e-32 115.0 COG0718@1|root,COG0718@2|Bacteria,1RGZD@1224|Proteobacteria,2VSJ2@28216|Betaproteobacteria,44VXA@713636|Nitrosomonadales 28216|Betaproteobacteria L Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection ybaB - - ko:K09747 - - - - ko00000 - - - YbaB_DNA_bd k59_1133098_1 314278.NB231_10924 6.62e-11 64.3 COG1195@1|root,COG1195@2|Bacteria,1MX8N@1224|Proteobacteria,1RN5P@1236|Gammaproteobacteria,1WYPF@135613|Chromatiales 135613|Chromatiales L it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP recF - - ko:K03629 ko03440,map03440 - - - ko00000,ko00001,ko03400 - - - AAA_23,SMC_N k59_1133098_2 187272.Mlg_0002 2.57e-87 270.0 COG0592@1|root,COG0592@2|Bacteria,1MVD9@1224|Proteobacteria,1RMNP@1236|Gammaproteobacteria,1WWQF@135613|Chromatiales 135613|Chromatiales L Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria - - 2.7.7.7 ko:K02338 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_beta,DNA_pol3_beta_2,DNA_pol3_beta_3 k59_1698040_1 1177154.Y5S_03440 7.68e-12 61.6 COG2900@1|root,COG2900@2|Bacteria,1NGFM@1224|Proteobacteria,1SGAM@1236|Gammaproteobacteria,1XMNQ@135619|Oceanospirillales 135619|Oceanospirillales S Belongs to the SlyX family slyX - - ko:K03745 - - - - ko00000 - - - SlyX k59_1698040_2 876044.IMCC3088_1730 1.18e-50 179.0 COG0281@1|root,COG0281@2|Bacteria,1MU0A@1224|Proteobacteria,1RN5F@1236|Gammaproteobacteria,1J4Q5@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C malic enzyme maeB - 1.1.1.38,1.1.1.40 ko:K00027,ko:K00029 ko00620,ko00710,ko01100,ko01120,ko01200,ko02020,map00620,map00710,map01100,map01120,map01200,map02020 M00169,M00172 R00214,R00216 RC00105 ko00000,ko00001,ko00002,ko01000 - - - Malic_M,PTA_PTB,malic k59_3204_1 744979.R2A130_0697 1.97e-16 72.4 COG0238@1|root,COG0238@2|Bacteria,1MZ8U@1224|Proteobacteria,2UC13@28211|Alphaproteobacteria 28211|Alphaproteobacteria J Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit rpsR GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02963 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S18 k59_3204_2 1122137.AQXF01000002_gene329 1.82e-74 228.0 COG0359@1|root,COG0359@2|Bacteria,1RD0R@1224|Proteobacteria,2TSC9@28211|Alphaproteobacteria 28211|Alphaproteobacteria J binds to the 23S rRNA rplI - - ko:K02939 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L9_C,Ribosomal_L9_N k59_963579_1 1156919.QWC_11541 2.26e-28 115.0 COG1819@1|root,COG1819@2|Bacteria,1MVI7@1224|Proteobacteria,2WG0J@28216|Betaproteobacteria,3T2ZX@506|Alcaligenaceae 28216|Betaproteobacteria CG glycosyl transferase - - - - - - - - - - - - UDPGT k59_234621_1 1122137.AQXF01000002_gene99 1.18e-52 170.0 2BNNA@1|root,32HB8@2|Bacteria,1R624@1224|Proteobacteria,2U216@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - MA20_42065 - - - - - - - - - - - - k59_234621_2 1282876.BAOK01000001_gene2275 2.62e-33 126.0 COG0174@1|root,COG0174@2|Bacteria,1MUGQ@1224|Proteobacteria,2TSCR@28211|Alphaproteobacteria,4BPWC@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria E TIGRFAM glutamine synthetase, type I glnA - 6.3.1.2 ko:K01915 ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 - R00253 RC00010,RC02798 ko00000,ko00001,ko01000,ko04147 - - - Gln-synt_C,Gln-synt_N k59_178243_1 1198114.AciX9_2462 1.55e-27 105.0 2DB76@1|root,2Z7JZ@2|Bacteria,3Y4EJ@57723|Acidobacteria,2JJ3S@204432|Acidobacteriia 204432|Acidobacteriia S T4-like virus tail tube protein gp19 - - - - - - - - - - - - Phage_T4_gp19 k59_178243_2 102129.Lepto7375DRAFT_2514 6.67e-31 122.0 2AAD4@1|root,30ZP1@2|Bacteria,1GAXN@1117|Cyanobacteria,1HDVA@1150|Oscillatoriales 1117|Cyanobacteria S PFAM T4 bacteriophage base plate protein - - - - - - - - - - - - T4_baseplate k59_291960_1 547163.BN979_00919 3.21e-13 70.9 COG0154@1|root,COG0154@2|Bacteria,2GKPZ@201174|Actinobacteria,238BI@1762|Mycobacteriaceae 201174|Actinobacteria J Amidase - - 6.3.5.6,6.3.5.7 ko:K02433 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - Amidase k59_743402_1 1122137.AQXF01000006_gene859 1.74e-08 55.1 COG0795@1|root,COG0795@2|Bacteria,1MVW3@1224|Proteobacteria,2TR76@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Permease, YjgP YjgQ family - - - ko:K11720 ko02010,map02010 M00320 - - ko00000,ko00001,ko00002,ko02000 1.B.42.1 - - YjgP_YjgQ k59_743402_2 1122137.AQXF01000006_gene860 3.57e-247 692.0 COG2244@1|root,COG2244@2|Bacteria,1RC9S@1224|Proteobacteria,2U63T@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Polysaccharide biosynthesis protein - - - - - - - - - - - - Polysacc_synt,Polysacc_synt_3,Polysacc_synt_C k59_743402_3 867900.Celly_0553 1.18e-57 207.0 COG4773@1|root,COG4773@2|Bacteria,4PM17@976|Bacteroidetes,1IKFD@117743|Flavobacteriia 976|Bacteroidetes P TonB dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - CarbopepD_reg_2,Plug,TonB_dep_Rec k59_800399_1 1282876.BAOK01000001_gene1808 1.88e-13 70.9 COG0044@1|root,COG0044@2|Bacteria,1MVXY@1224|Proteobacteria,2TSTM@28211|Alphaproteobacteria,4BPRA@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria F Amidohydrolase family pyrC - 3.5.2.3 ko:K01465 ko00240,ko01100,map00240,map01100 M00051 R01993 RC00632 ko00000,ko00001,ko00002,ko01000 - - - Amidohydro_1 k59_800399_2 1122137.AQXF01000002_gene634 1.32e-124 362.0 COG0540@1|root,COG0540@2|Bacteria,1MWAB@1224|Proteobacteria,2TRHP@28211|Alphaproteobacteria 28211|Alphaproteobacteria F Belongs to the ATCase OTCase family pyrB GO:0003674,GO:0003824,GO:0004070,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016741,GO:0016743,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.3.2 ko:K00609 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R01397 RC00064,RC02850 ko00000,ko00001,ko00002,ko01000 - - - OTCace,OTCace_N k59_516943_1 10224.XP_002731471.1 0.000145 47.8 COG0010@1|root,KOG2964@2759|Eukaryota,38BX2@33154|Opisthokonta,3BEYH@33208|Metazoa,3CU68@33213|Bilateria 33208|Metazoa E Belongs to the arginase family AGMAT GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0006807,GO:0008150,GO:0008152,GO:0008783,GO:0009058,GO:0016787,GO:0016810,GO:0016813,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0097055,GO:1901160,GO:1901162,GO:1901564,GO:1901566,GO:1901576 3.5.3.11 ko:K01480 ko00330,ko01100,map00330,map01100 M00133 R01157 RC00024,RC00329 ko00000,ko00001,ko00002,ko01000 - - - Arginase k59_1308410_1 702113.PP1Y_AT4745 6.78e-80 247.0 COG1622@1|root,COG1622@2|Bacteria,1MWHZ@1224|Proteobacteria,2TRK6@28211|Alphaproteobacteria,2K00C@204457|Sphingomonadales 204457|Sphingomonadales C Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) ctaC - 1.9.3.1 ko:K02275 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.4,3.D.4.6 - - COX2,COX2_TM k59_1138601_2 392499.Swit_4866 1.49e-23 100.0 COG4565@1|root,COG4963@1|root,COG4565@2|Bacteria,COG4963@2|Bacteria,1MWNY@1224|Proteobacteria,2TUDS@28211|Alphaproteobacteria,2K0BT@204457|Sphingomonadales 204457|Sphingomonadales TU Flp pilus assembly protein, ATPase CpaE cpaE - - ko:K02282 - - - - ko00000,ko02035,ko02044 - - - CbiA,ParA k59_1478238_1 644283.Micau_3530 5.86e-27 105.0 COG1652@1|root,COG1652@2|Bacteria,2I92Z@201174|Actinobacteria,4DBGP@85008|Micromonosporales 201174|Actinobacteria S LysM domain - - - - - - - - - - - - LysM k59_573604_1 754035.Mesau_03718 7.58e-41 147.0 COG1064@1|root,COG1064@2|Bacteria,1MUTT@1224|Proteobacteria,2TS0W@28211|Alphaproteobacteria,43J7R@69277|Phyllobacteriaceae 28211|Alphaproteobacteria S alcohol dehydrogenase adh - 1.1.1.1 ko:K00001 ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220 - R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310 RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273 ko00000,ko00001,ko01000 - - - ADH_N,ADH_zinc_N k59_573604_2 324602.Caur_3345 1.43e-44 155.0 COG2084@1|root,COG2084@2|Bacteria,2G6B3@200795|Chloroflexi,376B1@32061|Chloroflexia 32061|Chloroflexia I PFAM NADP oxidoreductase coenzyme F420-dependent - - 1.1.1.31 ko:K00020 ko00280,ko01100,map00280,map01100 - R05066 RC00099 ko00000,ko00001,ko01000 - - - NAD_binding_11,NAD_binding_2 k59_234644_1 652103.Rpdx1_4536 4.64e-83 253.0 COG1024@1|root,COG1024@2|Bacteria,1MWF6@1224|Proteobacteria,2TVBC@28211|Alphaproteobacteria,3JSPF@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria I Enoyl-CoA hydratase/isomerase - - - - - - - - - - - - ECH_1 k59_1026492_1 595537.Varpa_3009 1.1e-63 219.0 COG1640@1|root,COG3280@1|root,COG1640@2|Bacteria,COG3280@2|Bacteria,1QTVJ@1224|Proteobacteria,2WGPV@28216|Betaproteobacteria,4AD3R@80864|Comamonadaceae 28216|Betaproteobacteria G SMART alpha amylase catalytic sub domain treY - 2.4.1.25,5.4.99.15 ko:K00705,ko:K06044 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R01824,R05196,R09995 RC00049 ko00000,ko00001,ko00002,ko01000 - GH13,GH77 - Alpha-amylase,Glyco_hydro_77 k59_66078_1 436308.Nmar_0850 6.36e-103 305.0 arCOG07810@1|root,arCOG07810@2157|Archaea,41T26@651137|Thaumarchaeota 651137|Thaumarchaeota T PFAM Adenylate and Guanylate cyclase catalytic domain - - 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 - - - Guanylate_cyc k59_1703504_2 497964.CfE428DRAFT_4294 3.96e-13 70.1 COG5486@1|root,COG5486@2|Bacteria 2|Bacteria S Metal-binding integral membrane protein - - - - - - - - - - - - DUF2182 k59_516967_1 566466.NOR53_1309 3.8e-66 219.0 COG0659@1|root,COG0659@2|Bacteria,1MWDF@1224|Proteobacteria,1SYC8@1236|Gammaproteobacteria,1J50Y@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P COG0659 Sulfate permease and related transporters (MFS superfamily) sulP - - ko:K03321 - - - - ko00000,ko02000 2.A.53.3 - - STAS,Sulfate_transp k59_291981_1 649638.Trad_1478 4.85e-70 232.0 COG0154@1|root,COG0154@2|Bacteria,1WME1@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus J Amidase - - - - - - - - - - - - Amidase k59_800432_1 211586.SO_3261 9.7e-119 348.0 COG2089@1|root,COG2089@2|Bacteria,1MWG3@1224|Proteobacteria,1RPIG@1236|Gammaproteobacteria,2QAT6@267890|Shewanellaceae 1236|Gammaproteobacteria M PFAM N-acetylneuraminic acid synthase - - 2.5.1.56 ko:K01654 ko00520,ko01100,map00520,map01100 - R01804,R04435 RC00159 ko00000,ko00001,ko01000 - - - Cupin_2,NeuB,SAF k59_122330_1 382464.ABSI01000005_gene1329 6.37e-09 52.4 COG1758@1|root,COG1758@2|Bacteria,46W29@74201|Verrucomicrobia,2IUQD@203494|Verrucomicrobiae 203494|Verrucomicrobiae K RNA polymerase activity - - 2.7.7.6 ko:K03060 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb6 k59_122330_2 452637.Oter_2719 9.64e-62 194.0 COG0691@1|root,COG0691@2|Bacteria,46VG2@74201|Verrucomicrobia,3K83A@414999|Opitutae 414999|Opitutae O the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA smpB - - ko:K03664 - - - - ko00000 - - - SmpB k59_1703509_1 1229909.NSED_02615 7.71e-70 212.0 COG2007@1|root,arCOG04154@2157|Archaea,41SP2@651137|Thaumarchaeota 651137|Thaumarchaeota J Ribosomal protein S8e rps8e - - ko:K02995 ko03010,map03010 M00177,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S8e k59_1703509_2 1229909.NSED_02620 1.21e-104 305.0 COG1386@1|root,arCOG02613@2157|Archaea,41SIC@651137|Thaumarchaeota 651137|Thaumarchaeota K segregation and condensation protein - - - ko:K06024 - - - - ko00000,ko03036 - - - SMC_ScpB k59_1082353_1 1121124.JNIX01000005_gene1307 1.08e-08 57.8 COG1629@1|root,COG4771@2|Bacteria,1R533@1224|Proteobacteria,2TVP0@28211|Alphaproteobacteria,2KI6T@204458|Caulobacterales 204458|Caulobacterales P TonB dependent receptor - - - - - - - - - - - - Plug,TonB_dep_Rec k59_1082353_2 1121377.KB906398_gene2693 5.98e-11 63.5 COG1028@1|root,COG1028@2|Bacteria,1WM8P@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus IQ KR domain - - - - - - - - - - - - adh_short_C2 k59_1083013_2 1229909.NSED_02970 3.55e-24 101.0 COG0412@1|root,arCOG10350@1|root,arCOG01659@2157|Archaea,arCOG10350@2157|Archaea,41T1E@651137|Thaumarchaeota 651137|Thaumarchaeota Q Chlorophyllase - - 3.1.1.45 ko:K01061 ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130 - R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222 RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686 ko00000,ko00001,ko01000 - - - DLH k59_857585_1 1379270.AUXF01000002_gene1383 8.97e-43 155.0 COG2960@1|root,COG2960@2|Bacteria,1ZUAW@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Protein of unknown function (DUF1552) - - - - - - - - - - - - HXXSHH k59_517792_1 159450.NH14_19355 9.08e-51 177.0 COG0028@1|root,COG4032@1|root,COG0028@2|Bacteria,COG4032@2|Bacteria,1R6QP@1224|Proteobacteria,2VNIS@28216|Betaproteobacteria,1K11W@119060|Burkholderiaceae 28216|Betaproteobacteria EH phosphonopyruvate decarboxylase ppd - 4.1.1.82 ko:K09459 ko00440,ko01100,ko01120,ko01130,map00440,map01100,map01120,map01130 - R04053 RC00506 ko00000,ko00001,ko01000 - - - TPP_enzyme_C,TPP_enzyme_N k59_9972_2 216591.BCAL3121 5.61e-17 87.4 COG0451@1|root,COG0451@2|Bacteria,1MX2J@1224|Proteobacteria,2VJHC@28216|Betaproteobacteria,1K1YK@119060|Burkholderiaceae 28216|Betaproteobacteria M Nad-dependent epimerase dehydratase wbiG - 1.1.1.219,5.1.3.2 ko:K00091,ko:K01784 ko00052,ko00520,ko01100,map00052,map00520,map01100 M00361,M00362,M00632 R00291,R02984 RC00289 ko00000,ko00001,ko00002,ko01000 - - - Epimerase k59_857598_1 1096930.L284_03535 2.01e-91 277.0 COG0470@1|root,COG0470@2|Bacteria,1MY1W@1224|Proteobacteria,2TV3E@28211|Alphaproteobacteria,2JZZA@204457|Sphingomonadales 204457|Sphingomonadales L DNA polymerase holB - 2.7.7.7 ko:K02341 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_delta2 k59_1591149_1 1122137.AQXF01000002_gene327 7.87e-66 202.0 COG0360@1|root,COG0360@2|Bacteria,1RH82@1224|Proteobacteria,2U767@28211|Alphaproteobacteria 28211|Alphaproteobacteria J Binds together with S18 to 16S ribosomal RNA rpsF GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0019843,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070181,GO:0097159,GO:1901363,GO:1990904 - ko:K02990 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011,ko03029 - - - Ribosomal_S6 k59_1591149_2 509190.Cseg_2304 2.05e-09 57.8 COG0331@1|root,COG0331@2|Bacteria,1MV6N@1224|Proteobacteria,2TRTT@28211|Alphaproteobacteria,2KF69@204458|Caulobacterales 204458|Caulobacterales I malonyl CoA-acyl carrier protein transacylase fabD - 2.3.1.39 ko:K00645 ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212 M00082 R01626,R11671 RC00004,RC00039,RC02727 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Acyl_transf_1 k59_687527_1 743836.AYNA01000096_gene1956 4.3e-86 268.0 COG1262@1|root,COG1262@2|Bacteria,1MUNC@1224|Proteobacteria,2TQXE@28211|Alphaproteobacteria,36XC2@31993|Methylocystaceae 28211|Alphaproteobacteria S DinB superfamily - - - - - - - - - - - - DinB_2,FGE-sulfatase,Methyltransf_33 k59_122929_1 1229909.NSED_02185 1e-240 667.0 COG0065@1|root,arCOG01698@2157|Archaea,41S7A@651137|Thaumarchaeota 651137|Thaumarchaeota E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate leuC - 4.2.1.33,4.2.1.35 ko:K01703 ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230 M00432,M00535 R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170 RC00497,RC00976,RC00977,RC01041,RC01046,RC03072 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase k59_461593_1 1229909.NSED_09930 4.49e-48 163.0 COG1794@1|root,arCOG02005@2157|Archaea,41SM4@651137|Thaumarchaeota 651137|Thaumarchaeota M Asp/Glu/Hydantoin racemase - - 5.1.1.3 ko:K01776 ko00471,ko01100,map00471,map01100 - R00260 RC00302 ko00000,ko00001,ko01000,ko01011 - - - Asp_Glu_race k59_235374_1 1197719.A464_4418 3.97e-40 154.0 COG2911@1|root,COG2911@2|Bacteria,1MUVD@1224|Proteobacteria,1RMMF@1236|Gammaproteobacteria,3ZKJA@590|Salmonella 1236|Gammaproteobacteria S Pfam:DUF490 ytfN GO:0002790,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0032940,GO:0032991,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944,GO:0097347 - ko:K09800 - - - - ko00000,ko02000 - - - TamB k59_801087_1 1545915.JROG01000009_gene2742 2.04e-19 89.7 COG4452@1|root,COG4452@2|Bacteria,1MVVR@1224|Proteobacteria,2TVJ2@28211|Alphaproteobacteria,2K3GA@204457|Sphingomonadales 204457|Sphingomonadales V Inner membrane protein CreD - - - - - - - - - - - - CreD k59_687542_1 436308.Nmar_0475 3.35e-48 163.0 COG1131@1|root,arCOG00194@2157|Archaea,41TB9@651137|Thaumarchaeota 651137|Thaumarchaeota V Domain of unknown function (DUF4162) - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran,DUF4162 k59_66726_1 1328313.DS2_00905 2.36e-41 148.0 COG1683@1|root,COG3272@1|root,COG1683@2|Bacteria,COG3272@2|Bacteria,1MXYZ@1224|Proteobacteria,1RNMF@1236|Gammaproteobacteria,464ZQ@72275|Alteromonadaceae 1236|Gammaproteobacteria S Protein of unknown function (DUF1722) ybgA - - - - - - - - - - - DUF1722,DUF523 k59_349143_1 743722.Sph21_3029 1.77e-31 117.0 COG3000@1|root,COG3000@2|Bacteria,4NMV7@976|Bacteroidetes,1IRUI@117747|Sphingobacteriia 976|Bacteroidetes I Fatty acid hydroxylase - - - - - - - - - - - - FA_hydroxylase k59_1252798_1 1208321.D104_03930 2.01e-61 205.0 COG0364@1|root,COG0364@2|Bacteria,1MUN0@1224|Proteobacteria,1RN76@1236|Gammaproteobacteria,1XIBS@135619|Oceanospirillales 135619|Oceanospirillales G Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone zwf - 1.1.1.363,1.1.1.49 ko:K00036 ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230 M00004,M00006,M00008 R00835,R02736,R10907 RC00001,RC00066 ko00000,ko00001,ko00002,ko01000,ko04147 - - - G6PD_C,G6PD_N k59_687550_1 631362.Thi970DRAFT_03719 1.98e-21 99.4 COG2931@1|root,COG2982@1|root,COG3210@1|root,COG2931@2|Bacteria,COG2982@2|Bacteria,COG3210@2|Bacteria,1MU7T@1224|Proteobacteria 1224|Proteobacteria Q COG2931, RTX toxins and related Ca2 -binding proteins lapA - - ko:K12549,ko:K20276 ko02024,map02024 - - - ko00000,ko00001 - - - Cadherin_3,Calx-beta,HemolysinCabind,VWA,VWA_2 k59_1139459_1 243090.RB5028 2.84e-44 165.0 COG0470@1|root,COG0515@1|root,COG1262@1|root,COG0470@2|Bacteria,COG0515@2|Bacteria,COG1262@2|Bacteria,2IY3E@203682|Planctomycetes 203682|Planctomycetes KLT Sulfatase-modifying factor enzyme 1 - - - - - - - - - - - - FGE-sulfatase,Pkinase k59_1083043_1 257313.BP0102 1.5e-41 149.0 COG1686@1|root,COG1686@2|Bacteria,1MUU7@1224|Proteobacteria,2VH46@28216|Betaproteobacteria,3T1UE@506|Alcaligenaceae 28216|Betaproteobacteria M Belongs to the peptidase S11 family dacC - 3.4.16.4 ko:K07258 ko00550,ko01100,map00550,map01100 - - - ko00000,ko00001,ko01000,ko01002,ko01011 - - - PBP5_C,Peptidase_S11 k59_10003_2 349521.HCH_04360 8.76e-17 78.2 COG4446@1|root,COG4446@2|Bacteria,1N7IZ@1224|Proteobacteria,1SCZH@1236|Gammaproteobacteria,1XM4P@135619|Oceanospirillales 135619|Oceanospirillales S protein conserved in bacteria - - - - - - - - - - - - DUF1499 k59_631050_1 1538804.A0A0A1CM43_9CAUD 3.38e-43 162.0 4QB5I@10239|Viruses,4QPQ9@28883|Caudovirales,4QKRP@10699|Siphoviridae 10699|Siphoviridae S helicase activity - - - - - - - - - - - - - k59_1479146_1 288000.BBta_2190 9.08e-105 320.0 COG2303@1|root,COG2303@2|Bacteria,1MV19@1224|Proteobacteria,2TQKQ@28211|Alphaproteobacteria,3JSS3@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria E GMC oxidoreductase MA20_44990 - 1.1.99.1 ko:K00108 ko00260,ko01100,map00260,map01100 M00555 R01025 RC00087 ko00000,ko00001,ko00002,ko01000 - - - GMC_oxred_C,GMC_oxred_N k59_1479146_2 1121861.KB899917_gene3618 7.78e-16 73.2 2BQVQ@1|root,32JSN@2|Bacteria,1RJK4@1224|Proteobacteria,2UAA6@28211|Alphaproteobacteria,2JXH7@204441|Rhodospirillales 204441|Rhodospirillales S L-2-amino-thiazoline-4-carboxylic acid hydrolase - - - - - - - - - - - - ATC_hydrolase k59_1196114_1 436308.Nmar_1008 6.48e-106 327.0 COG0458@1|root,COG0624@1|root,arCOG01107@2157|Archaea,arCOG01596@2157|Archaea 2157|Archaea EF ATP-grasp domain cxp2 - 3.4.17.11,3.5.1.18,6.3.2.4 ko:K01295,ko:K01439,ko:K01921,ko:K16181 ko00300,ko00473,ko00550,ko01100,ko01120,ko01230,ko01502,map00300,map00473,map00550,map01100,map01120,map01230,map01502 M00016 R01150,R02734,R10011 RC00064,RC00090,RC00096,RC00141 ko00000,ko00001,ko00002,ko01000,ko01002,ko01011 - - - ATP-grasp_3,CPSase_L_D2,Dala_Dala_lig_C,M20_dimer,Peptidase_M20 k59_122958_1 1267533.KB906734_gene3984 2.68e-13 68.9 COG1664@1|root,COG1664@2|Bacteria,3Y49V@57723|Acidobacteria,2JJ4E@204432|Acidobacteriia 204432|Acidobacteriia M Polymer-forming cytoskeletal - - - - - - - - - - - - Bactofilin k59_122958_2 1379281.AVAG01000065_gene1146 1.13e-10 64.3 COG0004@1|root,COG0004@2|Bacteria,1NR9F@1224|Proteobacteria,42M8M@68525|delta/epsilon subdivisions,2WJE2@28221|Deltaproteobacteria,2M80K@213115|Desulfovibrionales 28221|Deltaproteobacteria P TIGRFAM Ammonium transporter - - - ko:K03320 - - - - ko00000,ko02000 1.A.11 - - Ammonium_transp k59_574537_1 1415778.JQMM01000001_gene697 1.49e-57 190.0 COG0439@1|root,COG0439@2|Bacteria,1MU4H@1224|Proteobacteria,1RMNB@1236|Gammaproteobacteria,1J50W@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria I Biotin carboxylase accC GO:0003674,GO:0003824,GO:0004075,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0016053,GO:0016874,GO:0016879,GO:0019216,GO:0019217,GO:0019222,GO:0019752,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032787,GO:0042304,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046394,GO:0046890,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051055,GO:0062012,GO:0062014,GO:0065007,GO:0071704,GO:0072330,GO:0080090,GO:1901576 6.3.4.14,6.4.1.2 ko:K01961 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04385 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 - - iSF_1195.SF3294 Biotin_carb_C,Biotin_carb_N,CPSase_L_D2 k59_574537_2 1411685.U062_01590 3.15e-57 182.0 COG0511@1|root,COG0511@2|Bacteria,1RCXA@1224|Proteobacteria,1S3YP@1236|Gammaproteobacteria,1J5XR@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria I first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA accB GO:0003674,GO:0003824,GO:0003989,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009305,GO:0009987,GO:0016049,GO:0016053,GO:0016421,GO:0016874,GO:0016885,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0040007,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0072330,GO:1901564,GO:1901576 - ko:K02160 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742 RC00040,RC00367 ko00000,ko00001,ko00002 - - iYL1228.KPN_03664 Biotin_lipoyl k59_122959_1 1278073.MYSTI_05384 9.18e-104 317.0 COG0459@1|root,COG0459@2|Bacteria,1MURR@1224|Proteobacteria,42M52@68525|delta/epsilon subdivisions,2WIRK@28221|Deltaproteobacteria,2YUQN@29|Myxococcales 28221|Deltaproteobacteria O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions groL GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0016465,GO:0032991,GO:0044183,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0051082,GO:0061077,GO:0101031,GO:1990220 - ko:K04077 ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 - - - Cpn60_TCP1 k59_574541_1 1042377.AFPJ01000052_gene1570 2.03e-24 100.0 COG3825@1|root,COG3825@2|Bacteria,1MUAJ@1224|Proteobacteria,1RMRY@1236|Gammaproteobacteria,464I9@72275|Alteromonadaceae 1236|Gammaproteobacteria S protein conserved in bacteria IV02_28405 - - ko:K09989 - - - - ko00000 - - - VWA_CoxE k59_1365855_1 43354.JOIJ01000011_gene2627 3.33e-46 155.0 COG0800@1|root,COG0800@2|Bacteria,2GNC0@201174|Actinobacteria,4E099@85010|Pseudonocardiales 201174|Actinobacteria G PFAM KDPG and KHG aldolase eda - 4.1.2.14,4.1.3.42 ko:K01625 ko00030,ko00630,ko01100,ko01120,ko01200,map00030,map00630,map01100,map01120,map01200 M00008,M00061,M00308,M00631 R00470,R05605 RC00307,RC00308,RC00435 ko00000,ko00001,ko00002,ko01000 - - - Aldolase k59_1365855_2 1178482.BJB45_11420 4.63e-14 73.2 COG0364@1|root,COG0364@2|Bacteria,1MUN0@1224|Proteobacteria,1RN76@1236|Gammaproteobacteria,1XIBS@135619|Oceanospirillales 135619|Oceanospirillales G Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone zwf - 1.1.1.363,1.1.1.49 ko:K00036 ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230 M00004,M00006,M00008 R00835,R02736,R10907 RC00001,RC00066 ko00000,ko00001,ko00002,ko01000,ko04147 - - - G6PD_C,G6PD_N k59_461654_1 1449076.JOOE01000002_gene955 3.27e-127 373.0 COG1304@1|root,COG1304@2|Bacteria,1MUEZ@1224|Proteobacteria,2TQNW@28211|Alphaproteobacteria,2K18M@204457|Sphingomonadales 204457|Sphingomonadales C Dehydrogenase lldD - 1.1.2.3 ko:K00101 ko00620,ko01100,map00620,map01100 - R00196 RC00044 ko00000,ko00001,ko01000 - - - FMN_dh k59_461654_2 1122137.AQXF01000005_gene1165 4.07e-132 392.0 COG1960@1|root,COG1960@2|Bacteria,1MU20@1224|Proteobacteria,2TQU2@28211|Alphaproteobacteria 28211|Alphaproteobacteria I acyl-CoA dehydrogenase aidB GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003995,GO:0005488,GO:0005515,GO:0006355,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008470,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016491,GO:0016627,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0033554,GO:0042802,GO:0043565,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051716,GO:0055114,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 - ko:K09456 - - - - ko00000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M k59_66763_1 1144305.PMI02_00183 3.11e-98 295.0 COG2348@1|root,COG2348@2|Bacteria,1MXFY@1224|Proteobacteria,2TTYM@28211|Alphaproteobacteria,2K1U6@204457|Sphingomonadales 204457|Sphingomonadales V Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_6 k59_631079_1 1122137.AQXF01000006_gene898 5.38e-27 108.0 COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,2TS8E@28211|Alphaproteobacteria 28211|Alphaproteobacteria I enoyl-CoA hydratase - - 1.1.1.35 ko:K07516 ko00071,ko00362,ko00650,ko01100,ko01120,ko01200,ko01212,map00071,map00362,map00650,map01100,map01120,map01200,map01212 M00087 R01975,R04737,R04739,R04741,R04743,R04745,R04748,R05305 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000 - - - 3HCDH,3HCDH_N,ECH_1 k59_631079_2 1122137.AQXF01000006_gene897 4.61e-95 284.0 COG1028@1|root,COG1028@2|Bacteria,1MXWI@1224|Proteobacteria,2TQQ6@28211|Alphaproteobacteria 28211|Alphaproteobacteria IQ COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - - - - - - - - - - - adh_short_C2 k59_744183_1 998674.ATTE01000001_gene2082 6.54e-62 201.0 COG1853@1|root,COG1853@2|Bacteria,1RGYM@1224|Proteobacteria,1RYBR@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Flavin reductase like domain - - - - - - - - - - - - Flavin_Reduct k59_631083_1 765911.Thivi_4593 7.51e-27 113.0 COG0497@1|root,COG0497@2|Bacteria,1MUNP@1224|Proteobacteria,1RNPZ@1236|Gammaproteobacteria,1WW15@135613|Chromatiales 135613|Chromatiales L May be involved in recombinational repair of damaged DNA recN - - ko:K03631 - - - - ko00000,ko03400 - - - SMC_N k59_631084_1 1144305.PMI02_01795 2.44e-131 374.0 COG0745@1|root,COG0745@2|Bacteria,1MY2Z@1224|Proteobacteria,2TRFZ@28211|Alphaproteobacteria,2K0QB@204457|Sphingomonadales 204457|Sphingomonadales T COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain phoB - - ko:K07657 ko02020,map02020 M00434 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Trans_reg_C k59_574558_1 1122137.AQXF01000003_gene2029 3.7e-32 124.0 COG0652@1|root,COG0652@2|Bacteria,1R4KH@1224|Proteobacteria 1224|Proteobacteria O PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides - - 5.2.1.8 ko:K03768 - - - - ko00000,ko01000,ko03110 - - - HEAT_2,Pro_isomerase k59_574558_2 1122137.AQXF01000003_gene2030 7.1e-165 465.0 COG0583@1|root,COG0583@2|Bacteria,1MV5N@1224|Proteobacteria,2TRAX@28211|Alphaproteobacteria 28211|Alphaproteobacteria K transcriptional regulator MA20_05050 - - - - - - - - - - - HTH_1,LysR_substrate k59_66772_1 867845.KI911784_gene334 7.87e-14 76.3 COG0566@1|root,COG0566@2|Bacteria,2G8ZW@200795|Chloroflexi 200795|Chloroflexi J RNA 2'-O ribose methyltransferase substrate binding - - - ko:K03437 - - - - ko00000,ko03016 - - - SpoU_methylase,SpoU_sub_bind k59_1252862_1 1123072.AUDH01000024_gene306 1.76e-53 190.0 COG0145@1|root,COG0145@2|Bacteria,1MU2Y@1224|Proteobacteria,2TQZ6@28211|Alphaproteobacteria,2JREA@204441|Rhodospirillales 204441|Rhodospirillales EQ Hydantoinase/oxoprolinase N-terminal region - - 3.5.2.14 ko:K01473 ko00330,ko01100,map00330,map01100 - R03187 RC00632 ko00000,ko00001,ko01000 - - - Hydant_A_N,Hydantoinase_A k59_687610_2 637390.AFOH01000046_gene2130 8.5e-45 164.0 COG0058@1|root,COG0058@2|Bacteria,1MW4J@1224|Proteobacteria,1RN8P@1236|Gammaproteobacteria,2NCB0@225057|Acidithiobacillales 225057|Acidithiobacillales G Protein of unknown function (DUF3417) - - 2.4.1.1 ko:K00688 ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931 - R02111 - ko00000,ko00001,ko01000 - GT35 - DUF3417,Phosphorylase k59_1146155_1 383372.Rcas_2197 4.83e-36 140.0 COG4932@1|root,COG4932@2|Bacteria,2GABV@200795|Chloroflexi,3752H@32061|Chloroflexia 32061|Chloroflexia M Cna B domain protein - - - - - - - - - - - - DUF11,SdrD_B k59_524334_1 1116472.MGMO_105c00580 1.39e-92 290.0 COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,1RMWA@1236|Gammaproteobacteria,1XER8@135618|Methylococcales 135618|Methylococcales JKL DEAD-box RNA helicase involved in various cellular processes at low temperature, including ribosome biogenesis, mRNA degradation and translation initiation deaD - 3.6.4.13 ko:K05592 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03009,ko03019 - - - DEAD,DbpA,Helicase_C k59_1486191_1 1232429.CBLL010000098_gene767 4.55e-13 72.8 COG0664@1|root,COG0664@2|Bacteria,2GMPN@201174|Actinobacteria,1W7T9@1268|Micrococcaceae 201174|Actinobacteria K Crp Fnr family glxR GO:0000166,GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006109,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010565,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0010675,GO:0016020,GO:0017076,GO:0019219,GO:0019222,GO:0030312,GO:0030551,GO:0030552,GO:0030554,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0032993,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043565,GO:0044212,GO:0044464,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0062012,GO:0065007,GO:0071944,GO:0080090,GO:0097159,GO:0097367,GO:0140110,GO:1901265,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2000874,GO:2001141 - ko:K10914 ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111 - - - ko00000,ko00001,ko03000 - - - HTH_Crp_2,cNMP_binding k59_1767831_2 1229909.NSED_08215 5.04e-62 191.0 arCOG08641@1|root,arCOG08641@2157|Archaea,41SU7@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1767831_3 1229909.NSED_08220 5.9e-59 186.0 COG1986@1|root,arCOG01223@2157|Archaea,41SKV@651137|Thaumarchaeota 651137|Thaumarchaeota H Cytidylyltransferase-like - - 2.7.7.3 ko:K02201 ko00770,ko01100,map00770,map01100 M00120 R03035 RC00002 ko00000,ko00001,ko00002,ko01000 - - - CTP_transf_like k59_581479_1 648757.Rvan_2054 1.28e-78 255.0 COG0419@1|root,COG0419@2|Bacteria,1R8F1@1224|Proteobacteria,2UA7D@28211|Alphaproteobacteria 28211|Alphaproteobacteria L ATPase involved in DNA repair - - - - - - - - - - - - AAA_23 k59_1373021_1 686340.Metal_0974 8.22e-19 90.5 COG1639@1|root,COG1639@2|Bacteria,1N7EN@1224|Proteobacteria,1RT8G@1236|Gammaproteobacteria,1XEN6@135618|Methylococcales 135618|Methylococcales T HDOD domain - - - - - - - - - - - - HDOD k59_976057_1 1096930.L284_20180 3.79e-21 90.9 COG0560@1|root,COG0560@2|Bacteria,1MWA3@1224|Proteobacteria,2TSEU@28211|Alphaproteobacteria,2K069@204457|Sphingomonadales 204457|Sphingomonadales E phosphoserine phosphatase serB - 3.1.3.3 ko:K01079 ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230 M00020 R00582 RC00017 ko00000,ko00001,ko00002,ko01000,ko01009 - - - HAD k59_976057_2 555793.WSK_1893 3.61e-41 144.0 COG0324@1|root,COG0324@2|Bacteria,1MUB2@1224|Proteobacteria,2TR8Z@28211|Alphaproteobacteria,2K0WU@204457|Sphingomonadales 204457|Sphingomonadales J Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) miaA - 2.5.1.75 ko:K00791 ko00908,ko01100,ko01110,map00908,map01100,map01110 - R01122 RC02820 ko00000,ko00001,ko01000,ko01006,ko03016 - - - IPPT k59_73951_1 436308.Nmar_0495 1.07e-121 358.0 COG0719@1|root,arCOG01715@2157|Archaea,41S5W@651137|Thaumarchaeota 651137|Thaumarchaeota O FeS assembly protein SufB - - - ko:K09014 - - - - ko00000 - - - UPF0051 k59_468367_1 443152.MDG893_14293 9.93e-93 278.0 COG3128@1|root,COG3128@2|Bacteria,1R838@1224|Proteobacteria,1S382@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Prolyl 4-hydroxylase alpha subunit homologues. - - - - - - - - - - - - 2OG-FeII_Oxy_3 k59_1203137_1 1219035.NT2_07_01850 9.86e-17 86.7 COG4773@1|root,COG4773@2|Bacteria,1QTXJ@1224|Proteobacteria,2U30T@28211|Alphaproteobacteria,2K228@204457|Sphingomonadales 204457|Sphingomonadales M TonB dependent receptor - - - - - - - - - - - - Plug,TonB_dep_Rec k59_1428563_1 1229909.NSED_00900 2.84e-53 174.0 COG0071@1|root,arCOG01832@2157|Archaea,41T6B@651137|Thaumarchaeota 651137|Thaumarchaeota O Belongs to the small heat shock protein (HSP20) family - - - ko:K13993 ko04141,map04141 - - - ko00000,ko00001,ko03110 - - - HSP20 k59_638832_1 754476.Q7A_741 1.31e-111 345.0 COG0058@1|root,COG0058@2|Bacteria,1MW4J@1224|Proteobacteria,1RN8P@1236|Gammaproteobacteria,46054@72273|Thiotrichales 72273|Thiotrichales G Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties - - 2.4.1.1 ko:K00688 ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931 - R02111 - ko00000,ko00001,ko01000 - GT35 - Phosphorylase k59_1656390_2 1219077.VAZ01S_024_00130 1.38e-32 117.0 COG3152@1|root,COG3152@2|Bacteria,1QECQ@1224|Proteobacteria,1SHDJ@1236|Gammaproteobacteria,1XYDS@135623|Vibrionales 135623|Vibrionales S Protein of unknown function (DUF805) - - - - - - - - - - - - DUF805 k59_808730_1 1267005.KB911257_gene705 7.8e-72 233.0 COG1748@1|root,COG1748@2|Bacteria,1P35E@1224|Proteobacteria,2TSYM@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Saccharopine dehydrogenase - - - - - - - - - - - - DUF4166,Sacchrp_dh_NADP k59_243206_1 420324.KI911955_gene3742 5.83e-195 557.0 COG1171@1|root,COG1171@2|Bacteria,1MVWJ@1224|Proteobacteria,2TTE1@28211|Alphaproteobacteria,1JT8D@119045|Methylobacteriaceae 28211|Alphaproteobacteria E Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA ilvA GO:0006082,GO:0006520,GO:0006566,GO:0006807,GO:0008150,GO:0008152,GO:0009066,GO:0009987,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0071704,GO:1901564,GO:1901605 4.3.1.19 ko:K01754 ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230 M00570 R00220,R00996 RC00418,RC02600 ko00000,ko00001,ko00002,ko01000 - - - PALP,Thr_dehydrat_C k59_130597_1 1265313.HRUBRA_00036 3.72e-57 182.0 COG0517@1|root,COG0517@2|Bacteria 2|Bacteria S IMP dehydrogenase activity - - - ko:K04767,ko:K07168,ko:K07182 - - - - ko00000 - - - CBS k59_300580_1 292415.Tbd_0795 5.75e-29 113.0 COG1044@1|root,COG1044@2|Bacteria,1MUX6@1224|Proteobacteria,2VHJR@28216|Betaproteobacteria,1KRZF@119069|Hydrogenophilales 119069|Hydrogenophilales M UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD - - 2.3.1.191 ko:K02536 ko00540,ko01100,map00540,map01100 M00060 R04550 RC00039,RC00166 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Hexapep,Hexapep_2,LpxD k59_300580_2 1502770.JQMG01000001_gene2000 1.56e-48 158.0 COG0764@1|root,COG0764@2|Bacteria,1RH2T@1224|Proteobacteria,2VRKQ@28216|Betaproteobacteria,2KMMW@206350|Nitrosomonadales 206350|Nitrosomonadales I Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs fabZ - 4.2.1.59 ko:K02372 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04428,R04535,R04537,R04544,R04568,R04954,R04965,R07764,R10117,R10121 RC00831,RC01095 ko00000,ko00001,ko00002,ko01000,ko01004 - - - FabA k59_17596_1 1123401.JHYQ01000021_gene1030 1.29e-68 218.0 COG0232@1|root,COG0232@2|Bacteria,1MVQ2@1224|Proteobacteria,1RPVJ@1236|Gammaproteobacteria,460J2@72273|Thiotrichales 72273|Thiotrichales F Belongs to the dGTPase family. Type 2 subfamily dgt - 3.1.5.1 ko:K01129 ko00230,map00230 - R01856 RC00017 ko00000,ko00001,ko01000 - - - HD,HD_assoc k59_921294_1 888064.HMPREF9088_1076 9.01e-26 105.0 COG2514@1|root,COG2514@2|Bacteria,1TPRF@1239|Firmicutes,4HAE7@91061|Bacilli,4B0D7@81852|Enterococcaceae 91061|Bacilli S Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily catE - 1.13.11.2 ko:K07104 ko00361,ko00362,ko00622,ko00643,ko01100,ko01120,ko01220,map00361,map00362,map00622,map00643,map01100,map01120,map01220 M00569 R00816,R04089,R05295,R05404,R05406,R07795 RC00387,RC00643,RC01075,RC01364,RC01914 ko00000,ko00001,ko00002,ko01000 - - - Glyoxalase k59_808753_1 1129794.C427_1572 2.44e-121 358.0 COG1228@1|root,COG1228@2|Bacteria,1MVAF@1224|Proteobacteria,1RQRP@1236|Gammaproteobacteria,46618@72275|Alteromonadaceae 1236|Gammaproteobacteria Q Amidohydrolase family - - - - - - - - - - - - Amidohydro_1 k59_808755_1 391625.PPSIR1_39520 3.11e-41 160.0 COG3899@1|root,COG4191@1|root,COG3899@2|Bacteria,COG4191@2|Bacteria,1R609@1224|Proteobacteria,42MTJ@68525|delta/epsilon subdivisions,2WJYM@28221|Deltaproteobacteria 28221|Deltaproteobacteria T COG0515 Serine threonine protein kinase - - - - - - - - - - - - AAA_16,GAF,GAF_2,HATPase_c,HisKA,PAS_3,PAS_4,PAS_9,Pkinase k59_921298_1 691883.XP_009497611.1 1.67e-38 141.0 COG0114@1|root,KOG1317@2759|Eukaryota,38GHX@33154|Opisthokonta 33154|Opisthokonta C fumarate hydratase activity - - 4.2.1.2 ko:K01679 ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04934,ko05200,ko05211,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200,map04934,map05200,map05211 M00009,M00011,M00173,M00376 R01082 RC00443 ko00000,ko00001,ko00002,ko01000 - - - FumaraseC_C,Lyase_1 k59_187399_1 1121286.AUMT01000002_gene1445 1.94e-13 72.8 COG0121@1|root,COG0121@2|Bacteria,4NFN5@976|Bacteroidetes,1I0E6@117743|Flavobacteriia,3ZPT5@59732|Chryseobacterium 976|Bacteroidetes S Phosphoinositide phospholipase C, Ca2+-dependent - - - - - - - - - - - - PI-PLC-C1 k59_187399_2 1088721.NSU_0275 1.3e-47 161.0 COG0582@1|root,COG0582@2|Bacteria,1R7GV@1224|Proteobacteria,2TT06@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Belongs to the 'phage' integrase family intD - - - - - - - - - - - Phage_integrase k59_130611_1 1120953.AUBH01000002_gene1454 1.76e-78 247.0 COG4656@1|root,COG4656@2|Bacteria,1QTUI@1224|Proteobacteria,1RMIM@1236|Gammaproteobacteria,4655V@72275|Alteromonadaceae 1236|Gammaproteobacteria C Part of a membrane complex involved in electron transport - - - ko:K03615 - - - - ko00000 - - - Complex1_51K,Fer4_17,Fer4_7,Fer4_8,RnfC_N,SLBB k59_1543055_1 105559.Nwat_2073 6.62e-73 229.0 COG0123@1|root,COG0123@2|Bacteria,1MU7P@1224|Proteobacteria,1RN8W@1236|Gammaproteobacteria,1WZ4R@135613|Chromatiales 135613|Chromatiales BQ PFAM histone deacetylase superfamily - - - ko:K04768 - - - - ko00000 - - - Hist_deacetyl k59_1317243_1 1046714.AMRX01000003_gene1 1.1e-12 68.2 COG3267@1|root,COG3267@2|Bacteria,1MU3G@1224|Proteobacteria,1RMI0@1236|Gammaproteobacteria,465NU@72275|Alteromonadaceae 1236|Gammaproteobacteria U general secretion pathway protein - - - - - - - - - - - - AAA_22 k59_1317243_2 1415780.JPOG01000001_gene2995 3.48e-38 139.0 COG0026@1|root,COG0026@2|Bacteria,1MU70@1224|Proteobacteria,1RQEI@1236|Gammaproteobacteria,1X31G@135614|Xanthomonadales 135614|Xanthomonadales F Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) purK - 6.3.4.18 ko:K01589 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R07404 RC01927 ko00000,ko00001,ko00002,ko01000 - - - ATP-grasp k59_1147150_1 929562.Emtol_1603 4.75e-47 172.0 COG0438@1|root,COG0438@2|Bacteria,4PKQN@976|Bacteroidetes,47K56@768503|Cytophagia 976|Bacteroidetes M PFAM glycogen synthase - - 2.4.1.11 ko:K00693 ko00500,ko01100,ko04151,ko04152,ko04910,ko04922,ko04931,map00500,map01100,map04151,map04152,map04910,map04922,map04931 - R00292 RC00005 ko00000,ko00001,ko01000,ko01003 - GT3 - Glycogen_syn k59_976916_1 765913.ThidrDRAFT_4015 7.06e-56 175.0 COG4577@1|root,COG4577@2|Bacteria,1RH1U@1224|Proteobacteria,1S72D@1236|Gammaproteobacteria,1WYP6@135613|Chromatiales 135613|Chromatiales CQ BMC - - - - - - - - - - - - BMC k59_1768750_1 640512.BC1003_5030 8.1e-72 236.0 COG0477@1|root,COG0477@2|Bacteria,1QTYG@1224|Proteobacteria,2VP53@28216|Betaproteobacteria,1K24S@119060|Burkholderiaceae 28216|Betaproteobacteria EGP Uncharacterised MFS-type transporter YbfB - - - - - - - - - - - - MFS_1,MFS_4,Sugar_tr k59_17641_1 1532557.JL37_19675 9.35e-35 133.0 COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2VHK8@28216|Betaproteobacteria 28216|Betaproteobacteria S protein conserved in bacteria - - - - - - - - - - - - TctC k59_582299_1 1229909.NSED_01315 1.74e-13 65.1 COG0713@1|root,arCOG03073@2157|Archaea,41SPM@651137|Thaumarchaeota 651137|Thaumarchaeota C NADH ubiquinone oxidoreductase subunit 11 or 4L (chain K) - - 1.6.5.3 ko:K00340 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q2 k59_582299_2 436308.Nmar_0284 3.8e-128 378.0 COG0651@1|root,arCOG01537@2157|Archaea,41SAV@651137|Thaumarchaeota 651137|Thaumarchaeota C plastoquinone (complex I) - - 1.6.5.3 ko:K00342,ko:K12137,ko:K12141 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Proton_antipo_M k59_1035432_1 1243664.CAVL020000041_gene3929 2.04e-07 55.5 COG2801@1|root,COG2801@2|Bacteria,1UYSY@1239|Firmicutes,4HTKB@91061|Bacilli 91061|Bacilli L Integrase core domain - - - - - - - - - - - - rve k59_1147182_1 314287.GB2207_02722 2.88e-46 155.0 COG1366@1|root,COG1366@2|Bacteria,1RIIT@1224|Proteobacteria,1S4RH@1236|Gammaproteobacteria,1JBX5@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T Anti-anti-sigma regulatory factor (Antagonist of anti-sigma factor) - - - - - - - - - - - - STAS k59_808808_2 656024.FsymDg_2074 1.84e-13 75.1 COG1012@1|root,COG1012@2|Bacteria,2GIWZ@201174|Actinobacteria 201174|Actinobacteria C Belongs to the aldehyde dehydrogenase family - - 1.2.1.3 ko:K00128 ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130 M00135 R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146 RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_1204023_1 436308.Nmar_1792 3.92e-182 521.0 COG0459@1|root,arCOG01257@2157|Archaea,41SDG@651137|Thaumarchaeota 651137|Thaumarchaeota O PFAM TCP-1 cpn60 chaperonin family - - - ko:K22447 - - - - ko00000,ko03110 - - - Cpn60_TCP1 k59_751797_2 485915.Dret_0570 2.23e-50 175.0 COG1536@1|root,COG1536@2|Bacteria,1MV9X@1224|Proteobacteria,42MS3@68525|delta/epsilon subdivisions,2WMCR@28221|Deltaproteobacteria,2M8WS@213115|Desulfovibrionales 28221|Deltaproteobacteria N flagellar motor switch protein FliG fliG - - ko:K02410 ko02030,ko02040,map02030,map02040 - - - ko00000,ko00001,ko02035 - - - FliG_C,FliG_M,FliG_N k59_1768789_1 316407.85676500 8.6e-86 266.0 COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria,1RNES@1236|Gammaproteobacteria,3XMYT@561|Escherichia 1236|Gammaproteobacteria E Dipeptide-binding protein of a transport system that can be subject to osmotic shock. DppA is also required for peptide chemotaxis dppA GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0006457,GO:0006810,GO:0006857,GO:0008150,GO:0009987,GO:0015833,GO:0020037,GO:0030288,GO:0030313,GO:0031975,GO:0033218,GO:0042277,GO:0042597,GO:0042886,GO:0042938,GO:0044464,GO:0046906,GO:0048037,GO:0051179,GO:0051234,GO:0061077,GO:0071702,GO:0071705,GO:0097159,GO:1901363 - ko:K02035,ko:K12368 ko02010,ko02024,ko02030,map02010,map02024,map02030 M00239,M00324 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - iSSON_1240.SSON_3846 SBP_bac_5 k59_300654_2 598659.NAMH_0018 6.57e-24 107.0 COG1351@1|root,COG1351@2|Bacteria 2|Bacteria F thymidylate synthase (FAD) activity thyX - 2.1.1.148 ko:K03465 ko00240,ko00670,ko01100,map00240,map00670,map01100 - R06613 RC00022,RC00332 ko00000,ko00001,ko01000 - - - Thy1 k59_17676_1 439375.Oant_1819 1.88e-38 144.0 COG0384@1|root,COG0384@2|Bacteria,1MUAS@1224|Proteobacteria,2U3ND@28211|Alphaproteobacteria,1J28Z@118882|Brucellaceae 28211|Alphaproteobacteria S Phenazine biosynthesis-like protein phzF - 5.3.3.17 ko:K06998 ko00405,ko01130,ko02024,map00405,map01130,map02024 M00835 - - ko00000,ko00001,ko00002,ko01000 - - - PhzC-PhzF k59_1768797_1 1380394.JADL01000002_gene1282 1.8e-71 226.0 COG2084@1|root,COG2084@2|Bacteria,1MWR4@1224|Proteobacteria,2U157@28211|Alphaproteobacteria,2JS1V@204441|Rhodospirillales 204441|Rhodospirillales I NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase - - - - - - - - - - - - NAD_binding_11,NAD_binding_2 k59_1090660_1 543728.Vapar_3707 5.15e-36 132.0 COG0800@1|root,COG0800@2|Bacteria,1MUVJ@1224|Proteobacteria,2VQWM@28216|Betaproteobacteria,4ABH8@80864|Comamonadaceae 28216|Betaproteobacteria G 2-dehydro-3-deoxyphosphogluconate aldolase 4-hydroxy-2-oxoglutarate aldolase eda - 4.1.2.14,4.1.3.42 ko:K01625 ko00030,ko00630,ko01100,ko01120,ko01200,map00030,map00630,map01100,map01120,map01200 M00008,M00061,M00308,M00631 R00470,R05605 RC00307,RC00308,RC00435 ko00000,ko00001,ko00002,ko01000 - - - Aldolase k59_1599293_1 766499.C357_01810 1.89e-14 72.4 COG0778@1|root,COG0778@2|Bacteria,1PKUV@1224|Proteobacteria,2U5MZ@28211|Alphaproteobacteria 28211|Alphaproteobacteria C Nitroreductase ydjA - - - - - - - - - - - Nitroreductase k59_1599293_2 1122137.AQXF01000001_gene2733 3.66e-20 90.1 COG2133@1|root,COG2133@2|Bacteria,1MVK5@1224|Proteobacteria,2TRN9@28211|Alphaproteobacteria 28211|Alphaproteobacteria G glucose sorbosone - - - - - - - - - - - - Cytochrome_CBB3,GSDH k59_1035474_1 83406.HDN1F_04560 2.31e-64 218.0 COG0025@1|root,COG0025@2|Bacteria,1QTUE@1224|Proteobacteria,1T1HJ@1236|Gammaproteobacteria,1J5D7@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P Sodium hydrogen exchanger nhaP - - ko:K03316 - - - - ko00000 2.A.36 - - Na_H_Exchanger,TrkA_N k59_582342_1 1492738.FEM21_25550 8.16e-63 218.0 COG1345@1|root,COG3291@1|root,COG1345@2|Bacteria,COG3291@2|Bacteria,4NDZC@976|Bacteroidetes,1HY1V@117743|Flavobacteriia,2P0RP@237|Flavobacterium 976|Bacteroidetes N Laminin G domain - - - - - - - - - - - - CHU_C,Cu-binding_MopE,DUF11,HYR,Laminin_G_3,PKD,SprB k59_1768801_2 1229909.NSED_05640 5.94e-45 154.0 COG5012@1|root,arCOG03402@2157|Archaea 2157|Archaea T Cobalamin B12-binding domain protein - - - ko:K16955,ko:K22491 ko00920,map00920 - R09997 RC00035 ko00000,ko00001,ko03000 - - - B12-binding,B12-binding_2 k59_1599297_1 314285.KT71_15019 6.27e-73 233.0 COG1726@1|root,COG1726@2|Bacteria,1MU36@1224|Proteobacteria,1RPU1@1236|Gammaproteobacteria,1J8UX@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol nqrA GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0006810,GO:0006811,GO:0006812,GO:0006814,GO:0008137,GO:0008150,GO:0008152,GO:0015672,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0030001,GO:0030964,GO:0032991,GO:0044425,GO:0050136,GO:0051179,GO:0051234,GO:0055114,GO:0098796,GO:1902494 1.6.5.8 ko:K00346 - - - - ko00000,ko01000 - - - NQRA,NQRA_SLBB k59_469313_1 1122137.AQXF01000005_gene1169 2.69e-158 454.0 COG3572@1|root,COG3572@2|Bacteria,1MU47@1224|Proteobacteria,2TRPT@28211|Alphaproteobacteria 28211|Alphaproteobacteria H glutamate--cysteine ligase gshA - 6.3.2.2 ko:K01919 ko00270,ko00480,ko01100,map00270,map00480,map01100 M00118 R00894,R10993 RC00064,RC00090 ko00000,ko00001,ko00002,ko01000 - - - GCS2 k59_865733_1 658187.LDG_6143 4.89e-23 105.0 COG0467@1|root,COG1119@1|root,COG0467@2|Bacteria,COG1119@2|Bacteria 2|Bacteria P ATPase activity - - - ko:K03546,ko:K06919,ko:K07452,ko:K08482,ko:K09384,ko:K10954 ko05110,map05110 - - - ko00000,ko00001,ko01000,ko02042,ko02048,ko03400 - - - AAA_11,AAA_12,AAA_25,DUF4011 k59_582347_1 316407.4062441 1.1e-106 308.0 2E0RG@1|root,32W9M@2|Bacteria,1RGQB@1224|Proteobacteria,1S32T@1236|Gammaproteobacteria,3XPB5@561|Escherichia 1236|Gammaproteobacteria S Protein of unknown function (DUF2593) ybjO GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - - - - - - - - - - DUF2593 k59_582347_2 316407.4062444 2.99e-74 231.0 COG2265@1|root,COG2265@2|Bacteria,1N8DN@1224|Proteobacteria,1RMX4@1236|Gammaproteobacteria,3XP7M@561|Escherichia 1236|Gammaproteobacteria J Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA rlmC GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016436,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.189 ko:K03212 - - - - ko00000,ko01000,ko03009 - - - tRNA_U5-meth_tr k59_1204048_1 379066.GAU_3911 8.45e-113 354.0 COG0249@1|root,COG0249@2|Bacteria,1ZST5@142182|Gemmatimonadetes 142182|Gemmatimonadetes L that it carries out the mismatch recognition step. This protein has a weak ATPase activity mutS - - ko:K03555 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V k59_74888_1 314287.GB2207_10933 5.83e-21 93.6 COG0037@1|root,COG0037@2|Bacteria,1MU85@1224|Proteobacteria,1RN14@1236|Gammaproteobacteria,1J5PD@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria D Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine tilS GO:0002097,GO:0002101,GO:0002136,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016879,GO:0032267,GO:0034470,GO:0034641,GO:0034660,GO:0042802,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 6.3.4.19 ko:K04075 - - R09597 RC02633,RC02634 ko00000,ko01000,ko03016 - - - ATP_bind_3,TilS,TilS_C k59_74888_2 377629.TERTU_1077 1.85e-26 105.0 COG0825@1|root,COG0825@2|Bacteria,1MURN@1224|Proteobacteria,1RNN8@1236|Gammaproteobacteria,2PMHF@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria I Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit accA GO:0001676,GO:0003674,GO:0003824,GO:0003989,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009317,GO:0009329,GO:0009987,GO:0016053,GO:0016421,GO:0016874,GO:0016885,GO:0019752,GO:0032787,GO:0032991,GO:0042759,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0072330,GO:1901576,GO:1902494,GO:1990234 2.1.3.15,6.4.1.2 ko:K01962 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04386 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 - - iAF1260.b0185,iBWG_1329.BWG_0177,iEC55989_1330.EC55989_0179,iECDH10B_1368.ECDH10B_0165,iECDH1ME8569_1439.ECDH1ME8569_0178,iECED1_1282.ECED1_0191,iECH74115_1262.ECH74115_0195,iECIAI1_1343.ECIAI1_0185,iECNA114_1301.ECNA114_0175,iECO111_1330.ECO111_0186,iECO26_1355.ECO26_0187,iECP_1309.ECP_0193,iECSE_1348.ECSE_0184,iECSF_1327.ECSF_0200,iECSP_1301.ECSP_0184,iECW_1372.ECW_m0181,iECs_1301.ECs0187,iEKO11_1354.EKO11_3733,iEcDH1_1363.EcDH1_3418,iEcE24377_1341.EcE24377A_0189,iEcHS_1320.EcHS_A0187,iG2583_1286.G2583_0188,iJN746.PP_1607,iJO1366.b0185,iJR904.b0185,iLF82_1304.LF82_0008,iNRG857_1313.NRG857_00945,iSDY_1059.SDY_0201,iSFV_1184.SFV_0168,iSF_1195.SF0175,iSFxv_1172.SFxv_0185,iS_1188.S0178,iUMNK88_1353.UMNK88_190,iWFL_1372.ECW_m0181,iY75_1357.Y75_RS00935,iZ_1308.Z0197 ACCA k59_1035489_1 1111728.ATYS01000010_gene237 2.56e-13 68.2 COG1704@1|root,COG1704@2|Bacteria,1REQE@1224|Proteobacteria,1S4TU@1236|Gammaproteobacteria 1236|Gammaproteobacteria S LemA family - - - ko:K03744 - - - - ko00000 - - - LemA k59_1035489_2 349163.Acry_3583 6.24e-31 121.0 COG0270@1|root,COG0270@2|Bacteria,1PPPH@1224|Proteobacteria,2VAY4@28211|Alphaproteobacteria,2JY24@204441|Rhodospirillales 204441|Rhodospirillales H C-5 cytosine-specific DNA methylase - - 2.1.1.37 ko:K00558 ko00270,ko01100,ko05206,map00270,map01100,map05206 M00035 R04858 RC00003,RC00332 ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036 - - - DNA_methylase k59_1599316_1 105559.Nwat_1520 7.65e-29 112.0 COG1881@1|root,COG1881@2|Bacteria,1N0Y4@1224|Proteobacteria,1S400@1236|Gammaproteobacteria,1WYBM@135613|Chromatiales 135613|Chromatiales S PFAM Phosphatidylethanolamine-binding protein - - - ko:K06910 - - - - ko00000 - - - PBP k59_695414_1 1117647.M5M_12985 1.1e-52 175.0 COG0730@1|root,COG0730@2|Bacteria,1RBHH@1224|Proteobacteria,1S4D0@1236|Gammaproteobacteria,1JA0U@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Sulfite exporter TauE/SafE - - - ko:K07090 - - - - ko00000 - - - TauE k59_695417_1 983545.Glaag_0600 2.31e-32 115.0 COG4327@1|root,COG4327@2|Bacteria,1N0TK@1224|Proteobacteria,1S8V9@1236|Gammaproteobacteria,468I1@72275|Alteromonadaceae 1236|Gammaproteobacteria S membrane - - - - - - - - - - - - DUF4212 k59_695417_2 1122137.AQXF01000005_gene1226 0.000866 40.8 COG4147@1|root,COG4147@2|Bacteria,1MVJ8@1224|Proteobacteria,2TTA4@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family - - - ko:K14393 - - - - ko00000,ko02000 2.A.21.7 - - SSF k59_1543168_1 1088721.NSU_4378 6.96e-130 377.0 COG0162@1|root,COG0162@2|Bacteria,1MVUQ@1224|Proteobacteria,2TQPA@28211|Alphaproteobacteria,2K11C@204457|Sphingomonadales 204457|Sphingomonadales J Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) tyrS - 6.1.1.1 ko:K01866 ko00970,map00970 M00359,M00360 R02918 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - S4,tRNA-synt_1b k59_469327_1 1122137.AQXF01000001_gene2728 1.78e-180 512.0 COG1680@1|root,COG1680@2|Bacteria,1P3SQ@1224|Proteobacteria,2TTI5@28211|Alphaproteobacteria 28211|Alphaproteobacteria V COG1680 Beta-lactamase class C and other penicillin binding proteins nylB - - - - - - - - - - - Beta-lactamase k59_469327_2 1150621.SMUL_1370 9.21e-55 179.0 COG0744@1|root,COG0744@2|Bacteria,1NXZS@1224|Proteobacteria 1224|Proteobacteria M Transglycosylase - - 2.4.1.129,3.4.16.4 ko:K05366 ko00550,ko01100,ko01501,map00550,map01100,map01501 - - - ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 - Transgly k59_1317361_1 338963.Pcar_2430 1.04e-60 196.0 COG0031@1|root,COG0031@2|Bacteria,1MUBE@1224|Proteobacteria,42N1R@68525|delta/epsilon subdivisions,2WJ7R@28221|Deltaproteobacteria,43S9J@69541|Desulfuromonadales 28221|Deltaproteobacteria E Pyridoxal-phosphate dependent enzyme cysK-1 - 2.5.1.47 ko:K01738 ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230 M00021 R00897,R03601,R04859 RC00020,RC02814,RC02821 ko00000,ko00001,ko00002,ko01000 - - - PALP k59_865747_1 1088721.NSU_3952 4.09e-120 349.0 2DB9X@1|root,2Z7ZS@2|Bacteria,1N6CK@1224|Proteobacteria,2U2ME@28211|Alphaproteobacteria,2K3K7@204457|Sphingomonadales 204457|Sphingomonadales S Protein of unknown function (DUF3445) - - 1.14.13.238 ko:K22342 - - - - ko00000,ko01000 - - - DUF3445 k59_300692_1 391615.ABSJ01000026_gene111 1.2e-63 211.0 COG2206@1|root,COG3437@1|root,COG2206@2|Bacteria,COG3437@2|Bacteria,1MV37@1224|Proteobacteria,1RM9C@1236|Gammaproteobacteria,1J8Z4@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria KT HD domain - - - - - - - - - - - - GAF,GAF_2,HD,HD_5,Lactamase_B_2 k59_921409_1 203122.Sde_0123 2.28e-29 112.0 COG3764@1|root,COG3764@2|Bacteria,1P806@1224|Proteobacteria,1S9RI@1236|Gammaproteobacteria,467ZM@72275|Alteromonadaceae 1236|Gammaproteobacteria M COG3764 Sortase (surface protein transpeptidase) srtA - 3.4.22.70 ko:K07284 - - - - ko00000,ko01000,ko01002,ko01011 - - - Sortase k59_921409_2 313606.M23134_03606 9.58e-17 77.4 COG0494@1|root,COG0494@2|Bacteria,4NMHV@976|Bacteroidetes,47P7M@768503|Cytophagia 976|Bacteroidetes L pfam nudix nudF - - - - - - - - - - - NUDIX k59_1317367_1 1229909.NSED_07735 1.42e-114 347.0 COG1389@1|root,arCOG01165@2157|Archaea,41SJ2@651137|Thaumarchaeota 651137|Thaumarchaeota L Relaxes both positive and negative superturns and exhibits a strong decatenase activity top6B - 5.99.1.3 ko:K03167 - - - - ko00000,ko01000,ko03032 - - - HATPase_c,Topo-VIb_trans k59_1379784_1 1096930.L284_05340 5.89e-82 258.0 2BVAG@1|root,32QQA@2|Bacteria,1NTSF@1224|Proteobacteria,2UP5E@28211|Alphaproteobacteria,2K1VH@204457|Sphingomonadales 204457|Sphingomonadales S Helix-turn-helix XRE-family like proteins - - - - - - - - - - - - - k59_23635_1 563192.HMPREF0179_02963 3.61e-30 124.0 COG1196@1|root,COG3941@1|root,COG1196@2|Bacteria,COG3941@2|Bacteria 2|Bacteria O tape measure - - - ko:K03529 - - - - ko00000,ko03036 - - - PhageMin_Tail,Tape_meas_lam_C k59_1661457_1 316407.4062505 2.15e-97 285.0 COG0431@1|root,COG0431@2|Bacteria,1MX40@1224|Proteobacteria,1RQGZ@1236|Gammaproteobacteria,3XMDI@561|Escherichia 1236|Gammaproteobacteria S Catalyzes an NADPH-dependent reduction of FMN, but is also able to reduce FAD or riboflavin ssuE GO:0003674,GO:0003824,GO:0006082,GO:0006790,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0008752,GO:0009056,GO:0009267,GO:0009605,GO:0009970,GO:0009987,GO:0009991,GO:0016043,GO:0016054,GO:0016491,GO:0016645,GO:0016646,GO:0019694,GO:0022607,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0042594,GO:0043933,GO:0044085,GO:0044237,GO:0044248,GO:0044273,GO:0044281,GO:0044282,GO:0046306,GO:0050896,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0051716,GO:0055114,GO:0065003,GO:0071496,GO:0071704,GO:0071840,GO:1901575 1.5.1.38 ko:K00299 ko00740,ko00920,ko01100,map00740,map00920,map01100 - R05706,R07210,R10206 RC00126,RC01779,RC02556 ko00000,ko00001,ko01000 - - iAF1260.b0937,iB21_1397.B21_00948,iBWG_1329.BWG_0789,iE2348C_1286.E2348C_0930,iECBD_1354.ECBD_2658,iECB_1328.ECB_00941,iECDH10B_1368.ECDH10B_1007,iECDH1ME8569_1439.ECDH1ME8569_0888,iECD_1391.ECD_00941,iECIAI1_1343.ECIAI1_0978,iECO103_1326.ECO103_0982,iECW_1372.ECW_m1047,iEKO11_1354.EKO11_2893,iETEC_1333.ETEC_1005,iEcDH1_1363.EcDH1_2706,iEcE24377_1341.EcE24377A_1052,iEcHS_1320.EcHS_A1046,iEcolC_1368.EcolC_2659,iJO1366.b0937,iSbBS512_1146.SbBS512_E2381,iUMNK88_1353.UMNK88_1092,iWFL_1372.ECW_m1047,iY75_1357.Y75_RS04870 FMN_red k59_23644_1 436308.Nmar_1540 1.17e-21 92.4 COG0122@1|root,arCOG00464@2157|Archaea,41SHE@651137|Thaumarchaeota 651137|Thaumarchaeota L 8-oxoguanine DNA glycosylase - - 4.2.99.18 ko:K03660 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - HhH-GPD k59_23644_2 1229909.NSED_08460 1.48e-163 467.0 COG1236@1|root,arCOG00541@2157|Archaea,41SAJ@651137|Thaumarchaeota 651137|Thaumarchaeota J exonuclease of the beta-lactamase fold involved in RNA processing - - - ko:K07577 - - - - ko00000 - - - Beta-Casp,Lactamase_B_6,RMMBL k59_1718278_1 82654.Pse7367_0856 0.000614 42.0 COG0147@1|root,COG0147@2|Bacteria,1G0KZ@1117|Cyanobacteria,1H6XQ@1150|Oscillatoriales 1117|Cyanobacteria E Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia trpE GO:0000162,GO:0003674,GO:0003824,GO:0004049,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005950,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016829,GO:0016830,GO:0016833,GO:0018130,GO:0019438,GO:0019752,GO:0032991,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494 4.1.3.27 ko:K01657 ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025 M00023 R00985,R00986 RC00010,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 - - - Anth_synt_I_N,Chorismate_bind k59_1718278_2 76114.ebA4199 1.26e-66 207.0 COG0512@1|root,COG0512@2|Bacteria,1MV5Y@1224|Proteobacteria,2VHGQ@28216|Betaproteobacteria,2KVJD@206389|Rhodocyclales 206389|Rhodocyclales EH anthranilate trpG - 4.1.3.27 ko:K01658 ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025 M00023 R00985,R00986 RC00010,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 - - - GATase k59_1322000_1 234267.Acid_7301 1.48e-51 181.0 COG3250@1|root,COG3250@2|Bacteria,3Y32Q@57723|Acidobacteria 57723|Acidobacteria G Belongs to the glycosyl hydrolase 2 family - - 3.2.1.31 ko:K01195 ko00040,ko00531,ko00860,ko00944,ko00983,ko01100,ko01110,ko04142,map00040,map00531,map00860,map00944,map00983,map01100,map01110,map04142 M00014,M00076,M00077,M00078,M00129 R01478,R04979,R07818,R08127,R08260,R10830 RC00055,RC00171,RC00529,RC00530,RC00714,RC01251 ko00000,ko00001,ko00002,ko01000 - - - Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N k59_871757_1 228410.NE0397 2.64e-70 221.0 COG1023@1|root,COG1023@2|Bacteria,1QU14@1224|Proteobacteria,2WH34@28216|Betaproteobacteria,372DN@32003|Nitrosomonadales 28216|Betaproteobacteria G 6-phosphogluconate dehydrogenase - - 1.1.1.343,1.1.1.44 ko:K00033 ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00480,map01100,map01110,map01120,map01130,map01200 M00004,M00006 R01528,R10221 RC00001,RC00539 ko00000,ko00001,ko00002,ko01000 - - - 6PGD,NAD_binding_2 k59_871757_2 663932.KB902575_gene2831 6.19e-05 44.7 COG0337@1|root,COG0703@1|root,COG0337@2|Bacteria,COG0703@2|Bacteria,1MUBK@1224|Proteobacteria,2TRDA@28211|Alphaproteobacteria,2JP8I@204441|Rhodospirillales 204441|Rhodospirillales E Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) aroB - 2.7.1.71,4.2.3.4 ko:K01735,ko:K13829 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02412,R03083 RC00002,RC00078,RC00847 ko00000,ko00001,ko00002,ko01000 - - - DHQ_synthase,SKI k59_756521_1 59374.Fisuc_0111 1.34e-25 105.0 COG3876@1|root,COG3876@2|Bacteria 2|Bacteria G Protein conserved in bacteria - - - - - - - - - - - - DUF1343 k59_1379812_1 112098.XP_008620313.1 1.82e-53 175.0 COG2896@1|root,KOG2876@2759|Eukaryota 2759|Eukaryota H cyclic pyranopterin monophosphate synthase activity - GO:0006732,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0018130,GO:0019538,GO:0019637,GO:0019720,GO:0043170,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0046483,GO:0051186,GO:0051188,GO:0051189,GO:0071704,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.99.22,4.6.1.17 ko:K03639,ko:K20967 ko00790,ko01100,ko04122,map00790,map01100,map04122 - R09394,R11372 RC03420,RC03425 ko00000,ko00001,ko01000 - - - Fer4_12,MoaC,Mob_synth_C,Radical_SAM k59_1041516_1 388051.AUFE01000004_gene919 1.39e-80 255.0 COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2VNJM@28216|Betaproteobacteria,1K04U@119060|Burkholderiaceae 28216|Betaproteobacteria IQ Long-chain fatty acid--CoA ligase - - 6.2.1.48 ko:K02182 - - - - ko00000,ko01000 - - - AMP-binding,AMP-binding_C k59_248917_1 1234595.C725_1869 6.14e-30 124.0 COG2211@1|root,COG2211@2|Bacteria,1MVUM@1224|Proteobacteria,2TVI8@28211|Alphaproteobacteria 28211|Alphaproteobacteria G COG2211 Na melibiose symporter and related transporters - - - - - - - - - - - - MFS_2 k59_1434439_1 351348.Maqu_0756 4.58e-151 446.0 COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,1RMBS@1236|Gammaproteobacteria,46485@72275|Alteromonadaceae 1236|Gammaproteobacteria NU Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB mshE - - ko:K12276 ko05111,map05111 - - - ko00000,ko00001,ko02044 - - - T2SSE,T2SSE_N k59_1152891_1 1122613.ATUP01000001_gene690 4.91e-64 203.0 COG3047@1|root,COG3047@2|Bacteria,1NUZJ@1224|Proteobacteria,2TRGI@28211|Alphaproteobacteria,43XDD@69657|Hyphomonadaceae 28211|Alphaproteobacteria M COG3047 Outer membrane protein W ompW - - ko:K07275 - - - - ko00000 - - - OmpW k59_1152891_2 1122137.AQXF01000003_gene2278 5.4e-19 79.0 COG3197@1|root,COG3197@2|Bacteria,1NG90@1224|Proteobacteria,2UJFJ@28211|Alphaproteobacteria 28211|Alphaproteobacteria P Cytochrome oxidase maturation protein fixS - - - - - - - - - - - FixS k59_1152891_3 1122137.AQXF01000003_gene2277 1.49e-58 200.0 COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,2TR80@28211|Alphaproteobacteria 28211|Alphaproteobacteria P P-type ATPase' - - 3.6.3.4 ko:K01533 - - R00086 RC00002 ko00000,ko01000 3.A.3.5 - - ATPase-cat_bd,E1-E2_ATPase,HMA,Hydrolase k59_643715_1 1035308.AQYY01000001_gene1971 3.37e-55 184.0 COG0697@1|root,COG0697@2|Bacteria,1TPST@1239|Firmicutes,248K5@186801|Clostridia,2619B@186807|Peptococcaceae 186801|Clostridia EG DMT(Drug metabolite transporter) superfamily permease - - - - - - - - - - - - EamA k59_1718298_1 1122137.AQXF01000001_gene3200 1.44e-73 224.0 COG0589@1|root,COG0589@2|Bacteria,1R9XB@1224|Proteobacteria,2U59E@28211|Alphaproteobacteria 28211|Alphaproteobacteria T Universal stress protein - - - - - - - - - - - - Usp k59_1718298_2 1122137.AQXF01000001_gene3201 9.26e-71 223.0 COG5345@1|root,COG5345@2|Bacteria,1MWVH@1224|Proteobacteria,2U0ZR@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Protein conserved in bacteria - - - - - - - - - - - - DUF2333 k59_306621_1 378806.STAUR_4649 6.36e-20 100.0 COG3829@1|root,COG4191@1|root,COG3829@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42M2K@68525|delta/epsilon subdivisions,2X4P8@28221|Deltaproteobacteria,2YZC7@29|Myxococcales 28221|Deltaproteobacteria T GHKL domain - - - - - - - - - - - - HATPase_c k59_701349_1 225849.swp_0847 9.67e-59 194.0 COG1282@1|root,COG1282@2|Bacteria,1MUP4@1224|Proteobacteria,1RMR4@1236|Gammaproteobacteria,2Q93R@267890|Shewanellaceae 1236|Gammaproteobacteria C The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane pntB - 1.6.1.2 ko:K00325 ko00760,ko01100,map00760,map01100 - R00112 RC00001 ko00000,ko00001,ko01000 - - - PNTB k59_701349_2 314287.GB2207_05312 1.17e-64 201.0 COG0764@1|root,COG0764@2|Bacteria,1MWV8@1224|Proteobacteria,1RP6W@1236|Gammaproteobacteria,1J5PF@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria I Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length fabA GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0008693,GO:0009058,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016860,GO:0016863,GO:0019171,GO:0019752,GO:0032787,GO:0034017,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0047451,GO:0071704,GO:0072330,GO:1901576 4.2.1.59,5.3.3.14 ko:K01716 ko00061,ko01100,ko01212,map00061,map01100,map01212 M00083 R04428,R04535,R04537,R04544,R04568,R04954,R04965,R07639 RC00831,RC01078,RC01095 ko00000,ko00001,ko00002,ko01000,ko01004 - - iAF1260.b0954,iB21_1397.B21_00965,iBWG_1329.BWG_0806,iE2348C_1286.E2348C_0940,iEC042_1314.EC042_1039,iECBD_1354.ECBD_2641,iECB_1328.ECB_00958,iECDH10B_1368.ECDH10B_1024,iECD_1391.ECD_00958,iECED1_1282.ECED1_0977,iECH74115_1262.ECH74115_1118,iECIAI1_1343.ECIAI1_0995,iECIAI39_1322.ECIAI39_2193,iECNA114_1301.ECNA114_1032,iECO103_1326.ECO103_1000,iECO111_1330.ECO111_1022,iECO26_1355.ECO26_1081,iECOK1_1307.ECOK1_1013,iECS88_1305.ECS88_0975,iECSF_1327.ECSF_0868,iECSP_1301.ECSP_1060,iECUMN_1333.ECUMN_1143,iECW_1372.ECW_m1064,iECs_1301.ECs1038,iEKO11_1354.EKO11_2876,iETEC_1333.ETEC_1024,iEcE24377_1341.EcE24377A_1068,iEcHS_1320.EcHS_A1063,iEcSMS35_1347.EcSMS35_2166,iEcolC_1368.EcolC_2642,iG2583_1286.G2583_1189,iJO1366.b0954,iJR904.b0954,iLF82_1304.LF82_0604,iSBO_1134.SBO_2277,iSDY_1059.SDY_0927,iSF_1195.SF0954,iSSON_1240.SSON_0958,iSbBS512_1146.SbBS512_E2362,iUMNK88_1353.UMNK88_1108,iWFL_1372.ECW_m1064,iY75_1357.Y75_RS04955,iZ_1308.Z1304,ic_1306.c1090 FabA k59_248943_1 1121403.AUCV01000007_gene1242 9.68e-95 284.0 COG0489@1|root,COG0489@2|Bacteria,1MU7R@1224|Proteobacteria,42NR0@68525|delta/epsilon subdivisions,2WIPG@28221|Deltaproteobacteria,2MHV5@213118|Desulfobacterales 28221|Deltaproteobacteria D Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP - - - - - - - - - - - - ParA k59_1549344_2 637389.Acaty_c1472 6.27e-35 127.0 COG4544@1|root,COG4544@2|Bacteria,1MZQU@1224|Proteobacteria,1S9RP@1236|Gammaproteobacteria,2NDRZ@225057|Acidithiobacillales 225057|Acidithiobacillales S Cell division inhibitor SulA - - - ko:K13053 - - - - ko00000,ko03036 - - - SulA k59_1095802_1 335543.Sfum_3264 3.71e-12 72.8 COG0574@1|root,COG0574@2|Bacteria,1N38V@1224|Proteobacteria,42MWC@68525|delta/epsilon subdivisions,2WKAZ@28221|Deltaproteobacteria,2MR7X@213462|Syntrophobacterales 28221|Deltaproteobacteria H Pyruvate phosphate dikinase, PEP/pyruvate binding domain - - - - - - - - - - - - PPDK_N k59_981834_1 502025.Hoch_5169 6.71e-96 291.0 COG0258@1|root,COG0258@2|Bacteria,1QV40@1224|Proteobacteria,43BZM@68525|delta/epsilon subdivisions,2X7AE@28221|Deltaproteobacteria,2YUE3@29|Myxococcales 28221|Deltaproteobacteria L Helix-hairpin-helix class 2 (Pol1 family) motifs - - - - - - - - - - - - 5_3_exonuc,5_3_exonuc_N k59_981834_2 1304865.JAGF01000001_gene1152 4.15e-05 45.1 COG4152@1|root,COG4152@2|Bacteria,2I2U6@201174|Actinobacteria 201174|Actinobacteria S AAA domain, putative AbiEii toxin, Type IV TA system - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - AAA_21,ABC_tran,DUF4162 k59_1209782_1 935840.JAEQ01000007_gene3862 1.27e-55 196.0 COG0060@1|root,COG0060@2|Bacteria,1MVBQ@1224|Proteobacteria,2TR3N@28211|Alphaproteobacteria,43GQG@69277|Phyllobacteriaceae 28211|Alphaproteobacteria J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) ileS - 6.1.1.5 ko:K01870 ko00970,map00970 M00359,M00360 R03656 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,tRNA-synt_1,zf-FPG_IleRS k59_474113_1 1229909.NSED_00865 2.87e-59 185.0 arCOG08025@1|root,arCOG08025@2157|Archaea,41STV@651137|Thaumarchaeota 651137|Thaumarchaeota S zinc-ribbon domain - - - - - - - - - - - - zinc_ribbon_2 k59_474113_2 1229909.NSED_00860 2.79e-84 253.0 arCOG08024@1|root,arCOG08024@2157|Archaea,41SRU@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - zinc_ribbon_2 k59_474113_3 436308.Nmar_0210 1.92e-68 207.0 COG0526@1|root,arCOG01972@2157|Archaea,41SSR@651137|Thaumarchaeota 651137|Thaumarchaeota O Thioredoxin - - - ko:K03671 ko04621,ko05418,map04621,map05418 - - - ko00000,ko00001,ko03110 - - - Thioredoxin k59_363352_2 1131266.ARWQ01000002_gene512 1.16e-121 366.0 COG0644@1|root,COG2440@1|root,arCOG00570@2157|Archaea,arCOG01984@2157|Archaea,41SXJ@651137|Thaumarchaeota 651137|Thaumarchaeota C Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains - - - ko:K00313 - - - - ko00000,ko01000 - - - - k59_363366_1 212042.APH_0802 4.11e-17 81.3 COG0681@1|root,COG0681@2|Bacteria,1MXUF@1224|Proteobacteria,2TR9N@28211|Alphaproteobacteria,47FF7@766|Rickettsiales 766|Rickettsiales U Belongs to the peptidase S26 family lepB - 3.4.21.89 ko:K03100 ko02024,ko03060,map02024,map03060 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_S24,Peptidase_S26 k59_363366_2 97096.XP_007789623.1 1.19e-10 66.6 COG3509@1|root,2SBTI@2759|Eukaryota,39SMX@33154|Opisthokonta,3NZNX@4751|Fungi,3QMGM@4890|Ascomycota,218D8@147550|Sordariomycetes 4751|Fungi Q ferulic acid esterase - - - - - - - - - - - - Esterase_phd k59_136630_1 316407.1742617 1.34e-32 122.0 COG1940@1|root,COG1940@2|Bacteria,1MX6M@1224|Proteobacteria,1RNZ1@1236|Gammaproteobacteria,3XMPM@561|Escherichia 1236|Gammaproteobacteria K Transcriptional repressor that regulates the expression of proteins that are part of the phosphotransferase system for sugar uptake. Regulates the expression of malT mlc GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097659,GO:1901360,GO:1901362,GO:1901363,GO:1901576 - ko:K15545 - - - - ko00000,ko03000 - - - ROK k59_136630_2 198214.SF1616 3.5e-51 169.0 COG0583@1|root,COG0583@2|Bacteria,1MXRP@1224|Proteobacteria,1RQP1@1236|Gammaproteobacteria 1236|Gammaproteobacteria K transcriptional regulator ynfL GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:1903506,GO:2000112,GO:2001141 - - - - - - - - - - HTH_1,LysR_substrate k59_643759_1 436308.Nmar_1004 7.39e-109 328.0 COG0405@1|root,arCOG04053@2157|Archaea 2157|Archaea E gamma-glutamyltransferase ggt - 2.3.2.2,3.4.19.13 ko:K00681 ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100 - R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935 RC00064,RC00090,RC00096 ko00000,ko00001,ko01000,ko01002 - - - G_glu_transpept k59_23730_1 305700.B447_06387 8.58e-14 80.1 COG2202@1|root,COG5002@1|root,COG2202@2|Bacteria,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,2WGK9@28216|Betaproteobacteria,2KZQA@206389|Rhodocyclales 206389|Rhodocyclales T Histidine Phosphotransfer domain - - - - - - - - - - - - HATPase_c,HisKA,Hpt,Response_reg k59_1493156_1 713586.KB900537_gene3302 1.76e-19 81.6 2DP4Q@1|root,330I8@2|Bacteria,1NAHJ@1224|Proteobacteria 1224|Proteobacteria S Protein of unknown function (DUF4031) - - - - - - - - - - - - DUF4031 k59_363374_1 1123393.KB891316_gene1136 2.35e-89 273.0 COG4992@1|root,COG4992@2|Bacteria,1MV3C@1224|Proteobacteria,2VHEB@28216|Betaproteobacteria,1KRJ2@119069|Hydrogenophilales 119069|Hydrogenophilales E Aminotransferase class-III argD - 2.6.1.11,2.6.1.17 ko:K00821 ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00028,M00845 R02283,R04475 RC00006,RC00062 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 k59_643765_1 1121921.KB898708_gene1533 2.88e-13 68.2 COG1196@1|root,COG1196@2|Bacteria,1MUAQ@1224|Proteobacteria,1RNA6@1236|Gammaproteobacteria,2PN2Z@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria L SMC proteins Flexible Hinge Domain smc - - ko:K03529 - - - - ko00000,ko03036 - - - SMC_N,SMC_hinge k59_643765_2 1415778.JQMM01000001_gene2047 9.04e-09 57.0 COG4235@1|root,COG4235@2|Bacteria,1MY4J@1224|Proteobacteria,1S358@1236|Gammaproteobacteria,1J627@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O COG4235 Cytochrome c biogenesis factor cycH - - ko:K02200 - - - - ko00000 - - - TPR_16,TPR_2 k59_1264730_1 395494.Galf_1617 1.19e-40 152.0 COG0492@1|root,COG0664@1|root,COG1142@1|root,COG0492@2|Bacteria,COG0664@2|Bacteria,COG1142@2|Bacteria,1PPH1@1224|Proteobacteria,2W9GU@28216|Betaproteobacteria,44WKA@713636|Nitrosomonadales 28216|Betaproteobacteria C FAD-dependent pyridine nucleotide-disulphide oxidoreductase - - - - - - - - - - - - Pyr_redox_3 k59_1379904_1 344747.PM8797T_16695 7.62e-45 169.0 COG0204@1|root,COG0318@1|root,COG0477@1|root,COG0204@2|Bacteria,COG0318@2|Bacteria,COG2814@2|Bacteria,2IXNF@203682|Planctomycetes 203682|Planctomycetes I AMP-dependent synthetase and ligase - - 2.3.1.40,6.2.1.20 ko:K05939 ko00071,ko00564,map00071,map00564 - R01406,R04864 RC00014,RC00039,RC00041 ko00000,ko00001,ko01000 - - - AMP-binding,Acyltransferase,MFS_1 k59_1264732_1 595537.Varpa_3008 4.96e-86 272.0 COG0296@1|root,COG0296@2|Bacteria,1MVM7@1224|Proteobacteria,2VJDX@28216|Betaproteobacteria,4AA76@80864|Comamonadaceae 28216|Betaproteobacteria G SMART alpha amylase catalytic sub domain treZ - 3.2.1.141 ko:K01236 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R09995,R11256 RC00049 ko00000,ko00001,ko00002,ko01000 - CBM48,GH13 - Alpha-amylase,CBM_48,DUF3459 k59_1605613_1 1137799.GZ78_20130 1.86e-59 196.0 COG1109@1|root,COG1109@2|Bacteria,1MU24@1224|Proteobacteria,1RMR2@1236|Gammaproteobacteria,1XH2Q@135619|Oceanospirillales 135619|Oceanospirillales G Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate glmM - 5.4.2.10 ko:K03431 ko00520,ko01100,ko01130,map00520,map01100,map01130 - R02060 RC00408 ko00000,ko00001,ko01000 - - - PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV k59_1605613_2 614083.AWQR01000005_gene1031 8.95e-07 50.1 COG0294@1|root,COG0294@2|Bacteria,1MUIR@1224|Proteobacteria,2VH2Q@28216|Betaproteobacteria,4AAWK@80864|Comamonadaceae 28216|Betaproteobacteria H Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives folP - 2.5.1.15 ko:K00796 ko00790,ko01100,map00790,map01100 M00126,M00841 R03066,R03067 RC00121,RC00842 ko00000,ko00001,ko00002,ko01000 - - - Pterin_bind k59_1661540_1 1122939.ATUD01000002_gene1440 4.9e-66 221.0 COG0147@1|root,COG0147@2|Bacteria,2GKJT@201174|Actinobacteria,4CPNJ@84995|Rubrobacteria 84995|Rubrobacteria EH Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia trpE - 4.1.3.27 ko:K01657 ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025 M00023 R00985,R00986 RC00010,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 - - - Anth_synt_I_N,Chorismate_bind k59_474139_1 316407.1736629 2.21e-98 286.0 COG3727@1|root,COG3727@2|Bacteria,1RH1C@1224|Proteobacteria,1S2V3@1236|Gammaproteobacteria,3XME9@561|Escherichia 1236|Gammaproteobacteria L May nick specific sequences that contain T G mispairs resulting from m5C-deamination vsr GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016788,GO:0033554,GO:0034641,GO:0043170,GO:0043765,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901363 - ko:K07458 - - - - ko00000,ko01000,ko03400 - - iB21_1397.ECBD_1686,iECD_1391.ECBD_1686 Vsr k59_474139_2 316407.1736630 2.24e-76 240.0 COG0270@1|root,COG0270@2|Bacteria,1MV9H@1224|Proteobacteria,1RPM4@1236|Gammaproteobacteria,3XPAF@561|Escherichia 1236|Gammaproteobacteria L This methylase recognizes the double-stranded sequence CCWGG, causes specific methylation on C-2 on both strands dcm GO:0003674,GO:0003824,GO:0003886,GO:0006139,GO:0006259,GO:0006304,GO:0006305,GO:0006306,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008757,GO:0009008,GO:0009987,GO:0016740,GO:0016741,GO:0032259,GO:0032776,GO:0034641,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044728,GO:0046483,GO:0071704,GO:0090116,GO:0090304,GO:0140097,GO:1901360 2.1.1.37 ko:K00558 ko00270,ko01100,ko05206,map00270,map01100,map05206 M00035 R04858 RC00003,RC00332 ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036 - - - DNA_methylase k59_1379915_1 1229909.NSED_02930 4.39e-27 105.0 arCOG08754@1|root,arCOG08754@2157|Archaea 1229909.NSED_02930|- - - - - - - - - - - - - - - - k59_1773225_1 1088721.NSU_1330 2.32e-45 154.0 COG0266@1|root,COG0266@2|Bacteria,1MVM5@1224|Proteobacteria,2TS4C@28211|Alphaproteobacteria,2K2A5@204457|Sphingomonadales 204457|Sphingomonadales L Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates fpg - 3.2.2.23,4.2.99.18 ko:K10563 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - Fapy_DNA_glyco,H2TH,zf-FPG_IleRS k59_1773225_2 1096930.L284_08135 6.26e-15 68.6 COG0268@1|root,COG0268@2|Bacteria,1MZ94@1224|Proteobacteria,2UC42@28211|Alphaproteobacteria,2K617@204457|Sphingomonadales 204457|Sphingomonadales J Binds directly to 16S ribosomal RNA rpsT - - ko:K02968 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S20p k59_1661552_1 335543.Sfum_3323 2.32e-06 55.1 COG0484@1|root,COG0484@2|Bacteria 2|Bacteria O heat shock protein binding - - - - - - - - - - - - DnaJ k59_1661552_2 436308.Nmar_0738 7.23e-09 54.3 COG1522@1|root,arCOG01580@2157|Archaea,41T4E@651137|Thaumarchaeota 651137|Thaumarchaeota K helix_turn_helix ASNC type - - - - - - - - - - - - AsnC_trans_reg,HTH_AsnC-type k59_1434518_1 43989.cce_4097 3.61e-33 138.0 COG0515@1|root,COG1672@1|root,COG2203@1|root,COG3899@1|root,COG0515@2|Bacteria,COG1672@2|Bacteria,COG2203@2|Bacteria,COG3899@2|Bacteria,1GD97@1117|Cyanobacteria,3KHHW@43988|Cyanothece 1117|Cyanobacteria T Serine Threonine protein kinase - - - - - - - - - - - - AAA_16,AAA_35,GAF,GAF_2,HATPase_c,HisKA,HisKA_3,PAS_4,Pkinase k59_1718405_1 404589.Anae109_1724 4.97e-60 214.0 COG1201@1|root,COG1201@2|Bacteria,1MUSW@1224|Proteobacteria,42Q75@68525|delta/epsilon subdivisions,2WMDY@28221|Deltaproteobacteria,2YU11@29|Myxococcales 28221|Deltaproteobacteria L DEAD DEAH box - - - ko:K03724 - - - - ko00000,ko01000,ko03400 - - - DEAD,DEAD_assoc,Helicase_C k59_926364_2 1305732.JAGG01000001_gene2365 4.11e-103 311.0 COG0761@1|root,COG0761@2|Bacteria,2GIZ7@201174|Actinobacteria,4FKVM@85023|Microbacteriaceae 201174|Actinobacteria IM Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis ispH - 1.17.7.4 ko:K03527 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05884,R08210 RC01137,RC01487 ko00000,ko00001,ko00002,ko01000 - - - LYTB k59_1605648_1 199310.c4900 4.45e-146 431.0 COG0376@1|root,COG0376@2|Bacteria,1MUBF@1224|Proteobacteria,1RNA5@1236|Gammaproteobacteria,3XNUR@561|Escherichia 1236|Gammaproteobacteria P Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity katG GO:0000302,GO:0003674,GO:0003824,GO:0004096,GO:0004601,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009636,GO:0009987,GO:0010035,GO:0016209,GO:0016491,GO:0016684,GO:0016999,GO:0017001,GO:0017144,GO:0020037,GO:0033554,GO:0034599,GO:0034614,GO:0035690,GO:0042221,GO:0042493,GO:0042542,GO:0042737,GO:0042743,GO:0042744,GO:0042802,GO:0044237,GO:0044248,GO:0044424,GO:0044444,GO:0044464,GO:0046677,GO:0046906,GO:0048037,GO:0050896,GO:0051186,GO:0051187,GO:0051716,GO:0055114,GO:0070301,GO:0070887,GO:0071236,GO:0072593,GO:0097159,GO:0097237,GO:0098754,GO:0098869,GO:1901363,GO:1901700,GO:1901701,GO:1990748 1.11.1.21 ko:K03782 ko00360,ko00380,ko00940,ko00983,ko01100,ko01110,map00360,map00380,map00940,map00983,map01100,map01110 - R00602,R00698,R02596,R02670,R03919,R04007,R07443,R11906 RC00034,RC00213,RC00767,RC02141 ko00000,ko00001,ko01000 - - iG2583_1286.G2583_4754 peroxidase k59_1265547_1 795666.MW7_2454 1.04e-91 295.0 COG0243@1|root,COG3383@1|root,COG0243@2|Bacteria,COG3383@2|Bacteria,1MW3N@1224|Proteobacteria,2VJG2@28216|Betaproteobacteria,1K5NF@119060|Burkholderiaceae 28216|Betaproteobacteria C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family fdhA - 1.17.1.9 ko:K00123 ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200 - R00519 RC02796 ko00000,ko00001,ko01000 - - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding k59_82232_1 1148.1653677 3.5e-29 114.0 COG3293@1|root,COG3293@2|Bacteria,1G0BW@1117|Cyanobacteria 1117|Cyanobacteria L Transposase - - - ko:K07492 - - - - ko00000 - - - DDE_Tnp_1,DUF4096 k59_82232_2 1121378.KB899743_gene3660 8.75e-08 52.4 COG3293@1|root,COG3293@2|Bacteria 2|Bacteria L Transposase - - - - - - - - - - - - DDE_Tnp_1,DDE_Tnp_1_2 k59_1211077_1 909663.KI867150_gene1349 2.96e-34 135.0 COG0247@1|root,COG0247@2|Bacteria,1MUMH@1224|Proteobacteria,42MIV@68525|delta/epsilon subdivisions,2WJ5X@28221|Deltaproteobacteria,2MQYC@213462|Syntrophobacterales 28221|Deltaproteobacteria C Nitrate reductase gamma subunit - - - - - - - - - - - - CCG,Fer4_10,Fer4_8,Nitrate_red_gam k59_1550735_1 1304874.JAFY01000002_gene722 1.15e-135 410.0 COG0542@1|root,COG0542@2|Bacteria,3TA3A@508458|Synergistetes 508458|Synergistetes O Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE clpB - - ko:K03695 ko04213,map04213 - - - ko00000,ko00001,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N k59_1662452_1 1122137.AQXF01000001_gene3198 8.68e-72 226.0 COG0457@1|root,COG0457@2|Bacteria,1RK4Q@1224|Proteobacteria,2UBBB@28211|Alphaproteobacteria 28211|Alphaproteobacteria S COG0457 FOG TPR repeat - - - - - - - - - - - - TPR_16,TPR_19,TPR_9 k59_1662452_2 1122137.AQXF01000001_gene3197 6.38e-115 347.0 COG0770@1|root,COG0770@2|Bacteria,1QTSF@1224|Proteobacteria,2TR0Q@28211|Alphaproteobacteria 28211|Alphaproteobacteria M Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein - - - - - - - - - - - - Mur_ligase_C,Mur_ligase_M k59_873063_1 452637.Oter_1629 1.25e-34 125.0 COG0266@1|root,COG0266@2|Bacteria 2|Bacteria L class I DNA-(apurinic or apyrimidinic site) endonuclease activity fpg - 3.2.2.23,4.2.99.18 ko:K10563 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - Fapy_DNA_glyco,H2TH,zf-FPG_IleRS k59_982763_1 1038858.AXBA01000006_gene934 3.35e-31 124.0 COG2199@1|root,COG3706@2|Bacteria,1MZV7@1224|Proteobacteria,2TRAF@28211|Alphaproteobacteria,3F1K5@335928|Xanthobacteraceae 28211|Alphaproteobacteria T SMART GGDEF domain containing protein MA20_36965 - - - - - - - - - - - GGDEF k59_530632_1 65393.PCC7424_2578 0.000111 48.5 COG3187@1|root,COG3187@2|Bacteria,1G96Y@1117|Cyanobacteria,3KHY5@43988|Cyanothece 1117|Cyanobacteria O META domain - - - ko:K03668 - - - - ko00000 - - - DUF4377,META k59_137832_1 498211.CJA_3783 3.1e-82 261.0 COG4974@1|root,COG4974@2|Bacteria,1NY1A@1224|Proteobacteria,1RN33@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Transposase - - - ko:K07484 - - - - ko00000 - - - DDE_Tnp_IS66,DDE_Tnp_IS66_C,LZ_Tnp_IS66,zf-IS66 k59_1391715_1 1223542.GM1_003_00900 7.3e-07 51.6 COG1231@1|root,COG1231@2|Bacteria,2GK23@201174|Actinobacteria,4GBRH@85026|Gordoniaceae 201174|Actinobacteria E Flavin containing amine oxidoreductase - - 1.4.3.4 ko:K00274 ko00260,ko00330,ko00340,ko00350,ko00360,ko00380,ko00950,ko00982,ko01100,ko01110,ko04726,ko04728,ko05030,ko05031,ko05034,map00260,map00330,map00340,map00350,map00360,map00380,map00950,map00982,map01100,map01110,map04726,map04728,map05030,map05031,map05034 M00135 R02173,R02382,R02529,R02532,R02613,R02908,R02919,R04025,R04300,R04674,R04890,R04893,R04894,R04907,R04908,R08346,R08347,R08348,R11354 RC00062,RC00160,RC00225,RC00676,RC00807,RC00808,RC01808,RC02226,RC02713 ko00000,ko00001,ko00002,ko01000 - - - Amino_oxidase k59_1391715_2 391625.PPSIR1_05866 3.34e-142 414.0 COG3328@1|root,COG3328@2|Bacteria,1MU4P@1224|Proteobacteria,42S30@68525|delta/epsilon subdivisions,2WQ5S@28221|Deltaproteobacteria 28221|Deltaproteobacteria L Transposase mutator type - - - - - - - - - - - - Transposase_mut k59_375109_1 247634.GPB2148_3724 1.41e-102 308.0 COG3199@1|root,COG3199@2|Bacteria,1MY3J@1224|Proteobacteria,1RP9X@1236|Gammaproteobacteria,1J4E9@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H ATP-NAD kinase - - - - - - - - - - - - NAD_kinase k59_1615519_1 641526.ADIWIN_0997 5.11e-57 195.0 COG0457@1|root,COG0457@2|Bacteria,4NE2V@976|Bacteroidetes,1HWRP@117743|Flavobacteriia 976|Bacteroidetes S FOG TPR repeat - - - - - - - - - - - - TPR_16,TPR_19,TPR_6,TPR_8 k59_823102_1 1207075.PputUW4_01515 1.35e-14 73.6 COG0583@1|root,COG0583@2|Bacteria,1MWUD@1224|Proteobacteria,1S5SM@1236|Gammaproteobacteria 1236|Gammaproteobacteria K Transcriptional regulator - - - - - - - - - - - - HTH_1,LysR_substrate k59_537507_1 886293.Sinac_3051 4.93e-35 135.0 COG0443@1|root,COG0443@2|Bacteria,2IXEC@203682|Planctomycetes 203682|Planctomycetes O Belongs to the heat shock protein 70 family - - - - - - - - - - - - DUF3731,HSP70 k59_1330186_1 1051646.VITU9109_15958 5.48e-25 108.0 COG1470@1|root,COG1858@1|root,COG3391@1|root,COG4625@1|root,COG5276@1|root,COG1470@2|Bacteria,COG1858@2|Bacteria,COG3391@2|Bacteria,COG4625@2|Bacteria,COG5276@2|Bacteria,1PF0U@1224|Proteobacteria,1T9X1@1236|Gammaproteobacteria,1Y027@135623|Vibrionales 135623|Vibrionales C repeat protein - - - - - - - - - - - - - k59_1273320_1 123899.JPQP01000003_gene1439 2.14e-42 152.0 COG3181@1|root,COG3181@2|Bacteria,1MWSC@1224|Proteobacteria,2VKK7@28216|Betaproteobacteria,3T5HD@506|Alcaligenaceae 28216|Betaproteobacteria S Tripartite tricarboxylate transporter family receptor - - - - - - - - - - - - TctC k59_482360_1 1343740.M271_39730 3.56e-11 65.9 COG4922@1|root,COG4922@2|Bacteria,2IA0H@201174|Actinobacteria 201174|Actinobacteria O SnoaL-like domain - - - - - - - - - - - - SnoaL,SnoaL_2 k59_318595_1 1242864.D187_003185 4.15e-27 112.0 COG2815@1|root,COG2815@2|Bacteria,1RIP7@1224|Proteobacteria,42XQG@68525|delta/epsilon subdivisions,2WT9P@28221|Deltaproteobacteria 28221|Deltaproteobacteria S TIR domain - - - - - - - - - - - - TIR_2 k59_1615537_2 1122137.AQXF01000002_gene592 4.92e-220 614.0 COG4663@1|root,COG4663@2|Bacteria,1MVMD@1224|Proteobacteria,2TS4J@28211|Alphaproteobacteria 28211|Alphaproteobacteria Q Part of the tripartite ATP-independent periplasmic (TRAP) transport system - - - - - - - - - - - - DctP k59_260430_1 478741.JAFS01000002_gene887 9.28e-71 230.0 COG0481@1|root,COG0481@2|Bacteria,46SA7@74201|Verrucomicrobia,37G9Y@326457|unclassified Verrucomicrobia 74201|Verrucomicrobia M Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner lepA - - ko:K03596 ko05134,map05134 - - - ko00000,ko00001 - - - EFG_C,EFG_II,GTP_EFTU,GTP_EFTU_D2,LepA_C k59_934783_1 47839.CCAU010000002_gene2708 4.24e-29 122.0 COG0515@1|root,COG0515@2|Bacteria,2H3K5@201174|Actinobacteria,23CBC@1762|Mycobacteriaceae 201174|Actinobacteria KLT serine threonine protein kinase - - - - - - - - - - - - - k59_375159_2 1122134.KB893650_gene25 2.27e-19 87.4 COG1572@1|root,COG1572@2|Bacteria,1RF0V@1224|Proteobacteria,1SY9C@1236|Gammaproteobacteria,1XNTV@135619|Oceanospirillales 135619|Oceanospirillales S CARDB - - - - - - - - - - - - CARDB,Metallopep,Peptidase_M10 k59_1330211_1 1278309.KB907100_gene1810 1.18e-85 266.0 COG0763@1|root,COG0763@2|Bacteria,1MVBI@1224|Proteobacteria,1RNS1@1236|Gammaproteobacteria,1XHF6@135619|Oceanospirillales 135619|Oceanospirillales M Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell lpxB - 2.4.1.182 ko:K00748 ko00540,ko01100,map00540,map01100 M00060 R04606 RC00005,RC00059 ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT19 - LpxB k59_1391777_2 1122137.AQXF01000005_gene1266 5.67e-54 175.0 COG0664@1|root,COG0664@2|Bacteria,1R5P7@1224|Proteobacteria,2TV0F@28211|Alphaproteobacteria 28211|Alphaproteobacteria K cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases hbaR - - ko:K21563 - - - - ko00000,ko03000 - - - HTH_Crp_2,cNMP_binding k59_91460_1 1229909.NSED_08865 1.45e-135 395.0 arCOG08791@1|root,arCOG08791@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_652429_1 1177181.T9A_00094 4.49e-171 487.0 COG1219@1|root,COG1219@2|Bacteria,1MVQK@1224|Proteobacteria,1RN9N@1236|Gammaproteobacteria,1XH3A@135619|Oceanospirillales 135619|Oceanospirillales O ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP clpX - - ko:K03544 ko04112,map04112 - - - ko00000,ko00001,ko03110 - - - AAA_2,ClpB_D2-small,zf-C4_ClpX k59_1273340_2 439235.Dalk_2323 1.39e-51 179.0 COG1960@1|root,COG1960@2|Bacteria,1PUXP@1224|Proteobacteria,42YQ2@68525|delta/epsilon subdivisions,2WUBI@28221|Deltaproteobacteria,2MMS0@213118|Desulfobacterales 28221|Deltaproteobacteria C Acyl-CoA dehydrogenase type 2 domain - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_713082_1 470145.BACCOP_02145 2.26e-22 95.1 COG0389@1|root,COG0389@2|Bacteria,4NF1Y@976|Bacteroidetes,2FNAN@200643|Bacteroidia,4AMAS@815|Bacteroidaceae 976|Bacteroidetes L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII dinB - 2.7.7.7 ko:K02346 - - - - ko00000,ko01000,ko03400 - - - IMS,IMS_C,IMS_HHH k59_713082_2 935567.JAES01000007_gene1877 2.05e-06 54.7 COG1566@1|root,COG1566@2|Bacteria,1RJ3I@1224|Proteobacteria,1S7BS@1236|Gammaproteobacteria,1X4Y6@135614|Xanthomonadales 135614|Xanthomonadales V Protein of unknown function (DUF3667) - - - - - - - - - - - - DUF3667 k59_934799_1 1122137.AQXF01000006_gene879 1.5e-11 63.9 COG5330@1|root,COG5330@2|Bacteria,1R3VY@1224|Proteobacteria,2TUQ8@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Uncharacterised protein conserved in bacteria (DUF2336) - - - - - - - - - - - - DUF2336 k59_934799_2 1122137.AQXF01000006_gene880 1.38e-19 84.0 COG1853@1|root,COG1853@2|Bacteria,1MZKY@1224|Proteobacteria,2U22K@28211|Alphaproteobacteria 28211|Alphaproteobacteria S PFAM flavin reductase domain protein, FMN-binding - - - - - - - - - - - - Flavin_Reduct k59_260454_1 1041147.AUFB01000019_gene5513 1.48e-94 295.0 COG1032@1|root,COG1032@2|Bacteria,1MY2Y@1224|Proteobacteria,2TUIT@28211|Alphaproteobacteria,4BMJ4@82115|Rhizobiaceae 28211|Alphaproteobacteria C Domain of unknown function (DUF4070) - - - - - - - - - - - - B12-binding,DUF4070,Radical_SAM k59_1163430_1 425104.Ssed_3150 2.29e-57 182.0 COG0764@1|root,COG0764@2|Bacteria,1RH2T@1224|Proteobacteria,1S63E@1236|Gammaproteobacteria,2QAP4@267890|Shewanellaceae 1236|Gammaproteobacteria I Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs fabZ GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0008693,GO:0009058,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0019171,GO:0019752,GO:0032787,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0047451,GO:0071704,GO:0072330,GO:1901576 4.2.1.59 ko:K02372 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04428,R04535,R04537,R04544,R04568,R04954,R04965,R07764,R10117,R10121 RC00831,RC01095 ko00000,ko00001,ko00002,ko01000,ko01004 - - iJN746.PP_1602 FabA k59_1163430_2 270374.MELB17_17138 0.000163 44.3 COG1043@1|root,COG1043@2|Bacteria,1MUHQ@1224|Proteobacteria,1RPHB@1236|Gammaproteobacteria,464XE@72275|Alteromonadaceae 1236|Gammaproteobacteria M Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell lpxA GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008374,GO:0008610,GO:0008654,GO:0008780,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016740,GO:0016746,GO:0016747,GO:0019637,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0046467,GO:0046493,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 2.3.1.129 ko:K00677 ko00540,ko01100,ko01503,map00540,map01100,map01503 M00060 R04567 RC00039,RC00055 ko00000,ko00001,ko00002,ko01000,ko01005 - - iPC815.YPO1056 Acetyltransf_11,Hexapep k59_202772_1 314275.MADE_1000315 6.55e-89 272.0 COG0156@1|root,COG0156@2|Bacteria,1MVVH@1224|Proteobacteria,1RNS6@1236|Gammaproteobacteria,465DM@72275|Alteromonadaceae 1236|Gammaproteobacteria H Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA kbl - 2.3.1.29 ko:K00639 ko00260,map00260 - R00371 RC00004,RC00394 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_1_2 k59_1330220_1 1122603.ATVI01000006_gene521 9.9e-13 67.0 COG0583@1|root,COG0583@2|Bacteria,1MU2E@1224|Proteobacteria,1RQ66@1236|Gammaproteobacteria,1XCKB@135614|Xanthomonadales 135614|Xanthomonadales K LysR substrate binding domain - - - - - - - - - - - - HTH_1,LysR_substrate k59_1330220_2 1500304.JQKY01000006_gene2733 7.2e-73 228.0 COG4221@1|root,COG4221@2|Bacteria,1R83E@1224|Proteobacteria,2TUS7@28211|Alphaproteobacteria,4B8YP@82115|Rhizobiaceae 28211|Alphaproteobacteria S Belongs to the short-chain dehydrogenases reductases (SDR) family - - - - - - - - - - - - adh_short k59_600012_1 1453503.AU05_11395 7.09e-32 121.0 COG1073@1|root,COG1073@2|Bacteria,1R8S6@1224|Proteobacteria,1S4WS@1236|Gammaproteobacteria 1236|Gammaproteobacteria S alpha beta - - - - - - - - - - - - FSH1,Lipase_3 k59_600012_2 985054.JQEZ01000009_gene3038 9.12e-19 85.9 COG0457@1|root,COG3118@1|root,COG0457@2|Bacteria,COG3118@2|Bacteria,1MVMG@1224|Proteobacteria,2TSGE@28211|Alphaproteobacteria,4NCQD@97050|Ruegeria 28211|Alphaproteobacteria O Sulfotransferase family - - - - - - - - - - - - Sulfotransfer_3,TPR_1,TPR_11,TPR_16,TPR_19,TPR_2,TPR_8 k59_1391797_1 225937.HP15_3223 2.41e-27 108.0 COG2264@1|root,COG2264@2|Bacteria,1MUPC@1224|Proteobacteria,1RNAR@1236|Gammaproteobacteria,4650B@72275|Alteromonadaceae 1236|Gammaproteobacteria J Ribosomal protein L11 methyltransferase prmA GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006479,GO:0006480,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0016278,GO:0016279,GO:0016740,GO:0016741,GO:0018011,GO:0018012,GO:0018022,GO:0018023,GO:0018193,GO:0018194,GO:0018205,GO:0019538,GO:0031365,GO:0032259,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0140096,GO:1901564 - ko:K02687 - - - - ko00000,ko01000,ko03009 - - - PrmA k59_1780490_1 1121899.Q764_07110 4.7e-10 61.6 COG0582@1|root,COG0582@2|Bacteria,4NI9Q@976|Bacteroidetes,1HZR0@117743|Flavobacteriia,2NT94@237|Flavobacterium 976|Bacteroidetes L Belongs to the 'phage' integrase family - - - - - - - - - - - - Phage_int_SAM_4,Phage_int_SAM_5,Phage_integrase k59_1780490_2 504487.JCM19302_2367 2.82e-17 75.5 COG3832@1|root,COG3832@2|Bacteria,4NNY1@976|Bacteroidetes,1I21X@117743|Flavobacteriia 976|Bacteroidetes S Pfam Activator of Hsp90 ATPase homolog 1-like protein - - - - - - - - - - - - AHSA1 k59_934813_1 1192759.AKIB01000052_gene912 2.23e-45 162.0 COG0654@1|root,COG0654@2|Bacteria,1MX9R@1224|Proteobacteria,2TR4U@28211|Alphaproteobacteria,2K3D6@204457|Sphingomonadales 204457|Sphingomonadales CH FAD binding domain - - 1.14.13.127 ko:K05712 ko00360,ko01120,ko01220,map00360,map01120,map01220 M00545 R06786,R06787 RC00236 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_3 k59_1273360_1 1090319.KE386571_gene956 1.58e-133 402.0 COG1472@1|root,COG1472@2|Bacteria,1MVIV@1224|Proteobacteria,2TS28@28211|Alphaproteobacteria,2K11N@204457|Sphingomonadales 204457|Sphingomonadales G Glycosyl hydrolase family 3 C-terminal domain - - 3.2.1.21 ko:K05349 ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110 - R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040 RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248 ko00000,ko00001,ko01000 - GH3 - Glyco_hydro_3,Glyco_hydro_3_C k59_652447_2 1122214.AQWH01000003_gene4067 9.76e-28 105.0 COG0251@1|root,COG0251@2|Bacteria,1MZ3J@1224|Proteobacteria,2UEXI@28211|Alphaproteobacteria 28211|Alphaproteobacteria J Endoribonuclease L-PSP - - 3.5.99.10 ko:K09022 - - R11098,R11099 RC03275,RC03354 ko00000,ko01000 - - - Ribonuc_L-PSP k59_652447_3 717785.HYPMC_2132 1.23e-25 100.0 COG0782@1|root,COG0782@2|Bacteria,1RCXW@1224|Proteobacteria,2U5JU@28211|Alphaproteobacteria,3N6TK@45401|Hyphomicrobiaceae 28211|Alphaproteobacteria K Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides greA - - ko:K03624 - - - - ko00000,ko03021 - - - GreA_GreB,GreA_GreB_N k59_713112_1 1229909.NSED_06065 2.3e-17 77.4 COG1611@1|root,arCOG02431@2157|Archaea,41SMW@651137|Thaumarchaeota 651137|Thaumarchaeota S Rossmann fold nucleotide-binding protein - - 3.2.2.10 ko:K06966 ko00230,ko00240,map00230,map00240 - R00182,R00510 RC00063,RC00318 ko00000,ko00001,ko01000 - - - Lysine_decarbox k59_714147_1 13689.BV96_00626 5.06e-73 232.0 COG0654@1|root,COG0654@2|Bacteria,1MWWT@1224|Proteobacteria,2TRZP@28211|Alphaproteobacteria,2K12Z@204457|Sphingomonadales 204457|Sphingomonadales CH FAD binding domain - - - - - - - - - - - - FAD_binding_3 k59_765574_1 278957.ABEA03000051_gene206 6.19e-33 119.0 COG0768@1|root,COG0768@2|Bacteria,46SEZ@74201|Verrucomicrobia,3K799@414999|Opitutae 414999|Opitutae M Penicillin binding protein transpeptidase domain - - 3.4.16.4 ko:K03587 ko00550,ko01501,map00550,map01501 - - - ko00000,ko00001,ko01000,ko01011,ko03036 - - - PBP_dimer,Transpeptidase k59_714155_1 1049564.TevJSym_ad00990 2.92e-36 130.0 COG3000@1|root,COG3000@2|Bacteria,1MW5G@1224|Proteobacteria,1RQJQ@1236|Gammaproteobacteria,1J5P9@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria I Fatty acid hydroxylase superfamily - - - - - - - - - - - - FA_hydroxylase k59_714155_2 1182590.BN5_03381 1.32e-21 95.9 COG2813@1|root,COG2813@2|Bacteria,1NEMR@1224|Proteobacteria,1RMXE@1236|Gammaproteobacteria,1YD8G@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria J Specifically methylates the guanine in position 1835 (m2G1835) of 23S rRNA rlmG GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0008990,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0052916,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.172,2.1.1.174 ko:K00564,ko:K11391 - - R07234 RC00003 ko00000,ko01000,ko03009 - - - MTS k59_601087_1 224911.27351117 8.82e-44 157.0 COG0845@1|root,COG0845@2|Bacteria,1MUFW@1224|Proteobacteria,2U2CU@28211|Alphaproteobacteria,3JQRQ@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family MA20_16810 - - ko:K18306 ko02024,map02024 M00644 - - ko00000,ko00001,ko00002,ko02000 2.A.6.2.20,2.A.6.2.32,8.A.1 - - HlyD_D23 k59_376223_2 1244869.H261_19279 1.96e-41 139.0 COG2127@1|root,COG2127@2|Bacteria,1MZU8@1224|Proteobacteria,2U982@28211|Alphaproteobacteria,2JSWP@204441|Rhodospirillales 204441|Rhodospirillales S Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation clpS - - ko:K06891 - - - - ko00000 - - - ClpS k59_1164462_1 1168065.DOK_00460 1.02e-110 340.0 COG4257@1|root,COG4257@2|Bacteria,1R448@1224|Proteobacteria,1T0QH@1236|Gammaproteobacteria,1J7GQ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria V COG4257 Streptogramin lyase - - - - - - - - - - - - CarboxypepD_reg k59_824261_1 1122137.AQXF01000002_gene120 3.74e-274 763.0 COG1009@1|root,COG1009@2|Bacteria,1MW2M@1224|Proteobacteria,2TQSS@28211|Alphaproteobacteria 28211|Alphaproteobacteria CP NADH ubiquinone oxidoreductase subunit 5 (chain L) multisubunit Na H antiporter, MnhA subunit nuoL - 1.6.5.3 ko:K00341 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - NADH5_C,Proton_antipo_M,Proton_antipo_N k59_824261_2 990285.RGCCGE502_07861 9.09e-18 76.6 COG0713@1|root,COG0713@2|Bacteria,1RH0S@1224|Proteobacteria,2U93P@28211|Alphaproteobacteria,4BF8F@82115|Rhizobiaceae 28211|Alphaproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoK GO:0003674,GO:0003824,GO:0003954,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0016655,GO:0050136,GO:0055114 1.6.5.3 ko:K00340 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q2 k59_1728945_1 1127673.GLIP_0557 6.53e-05 44.7 COG0654@1|root,COG0654@2|Bacteria,1MU6I@1224|Proteobacteria,1RND5@1236|Gammaproteobacteria,464ZN@72275|Alteromonadaceae 1236|Gammaproteobacteria CH COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases visC GO:0003674,GO:0003824,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016491,GO:0019168,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:1901576,GO:1901661,GO:1901663 - ko:K18800 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00117 R04987,R08768 RC00046 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_3 k59_1728945_2 2340.JV46_14160 5.25e-73 228.0 COG0025@1|root,COG0025@2|Bacteria,1MW5T@1224|Proteobacteria,1RPH6@1236|Gammaproteobacteria,1J693@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P Na H and K H nhaP - - ko:K03316 - - - - ko00000 2.A.36 - - Na_H_Exchanger k59_1671068_1 393480.FNP_2382 5.95e-07 57.0 COG2984@1|root,COG2984@2|Bacteria,378FN@32066|Fusobacteria 32066|Fusobacteria S ABC transporter substrate binding protein - - - ko:K01989 - M00247 - - ko00000,ko00002,ko02000 - - - ABC_sub_bind k59_653246_1 247639.MGP2080_10038 3.79e-20 88.2 COG1737@1|root,COG1737@2|Bacteria,1MV3U@1224|Proteobacteria,1RNC4@1236|Gammaproteobacteria 1236|Gammaproteobacteria K transcriptional regulator hexR GO:0000976,GO:0001067,GO:0001130,GO:0001131,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0006950,GO:0006974,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032991,GO:0032993,GO:0033554,GO:0043565,GO:0044212,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051716,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2001141 - ko:K19337 - - - - ko00000,ko03000 - - - HTH_6,SIS k59_884652_1 887898.HMPREF0551_0578 2.6e-75 243.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2VHSB@28216|Betaproteobacteria,1K0NH@119060|Burkholderiaceae 28216|Betaproteobacteria T nitrogen regulation protein ntrC GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0043565,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:2000112,GO:2000113,GO:2001141 - ko:K07712 ko02020,map02020 M00497 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_1616362_1 1150599.MPHLEI_23599 3.83e-32 119.0 COG1309@1|root,COG1309@2|Bacteria,2I8Z7@201174|Actinobacteria,234JD@1762|Mycobacteriaceae 201174|Actinobacteria K tetR family - - - - - - - - - - - - TetR_N k59_1728949_1 314287.GB2207_09606 1.17e-51 174.0 COG0701@1|root,COG0701@2|Bacteria,1MUN8@1224|Proteobacteria,1RSPM@1236|Gammaproteobacteria 1236|Gammaproteobacteria S permease - - - ko:K07089 - - - - ko00000 - - - ArsP_1 k59_1274079_1 1122137.AQXF01000002_gene302 1.97e-123 367.0 COG0248@1|root,COG0248@2|Bacteria,1MV35@1224|Proteobacteria,2TR1W@28211|Alphaproteobacteria 28211|Alphaproteobacteria FP exopolyphosphatase ppx - 3.6.1.11,3.6.1.40 ko:K01524 ko00230,map00230 - R03409 RC00002 ko00000,ko00001,ko01000 - - - Ppx-GppA k59_1164480_1 1123371.ATXH01000004_gene1768 2.32e-70 223.0 COG1338@1|root,COG1338@2|Bacteria,2GGQQ@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria N Plays a role in the flagellum-specific transport system fliP - - ko:K02419 ko02040,map02040 - - - ko00000,ko00001,ko02035,ko02044 3.A.6.2 - - FliP k59_1164480_2 1121935.AQXX01000117_gene5107 2.2e-17 77.0 COG1987@1|root,COG1987@2|Bacteria,1PC3J@1224|Proteobacteria,1SHJR@1236|Gammaproteobacteria 1236|Gammaproteobacteria NU Bacterial export proteins, family 3 - - - ko:K02420 ko02040,map02040 - - - ko00000,ko00001,ko02035,ko02044 3.A.6.2 - - Bac_export_3 k59_319746_1 1205753.A989_04998 2.02e-65 216.0 COG2141@1|root,COG2141@2|Bacteria,1MX64@1224|Proteobacteria,1SCEP@1236|Gammaproteobacteria,1XCJK@135614|Xanthomonadales 135614|Xanthomonadales C Luciferase-like monooxygenase - - - - - - - - - - - - Bac_luciferase k59_653254_1 391625.PPSIR1_35372 1.49e-41 156.0 COG0404@1|root,COG0665@1|root,COG0404@2|Bacteria,COG0665@2|Bacteria,1MUXJ@1224|Proteobacteria,42YZ6@68525|delta/epsilon subdivisions,2WU2X@28221|Deltaproteobacteria,2YXQD@29|Myxococcales 28221|Deltaproteobacteria E FAD dependent oxidoreductase central domain - - - - - - - - - - - - DAO,FAO_M,GCV_T,GCV_T_C k59_1392886_2 1122137.AQXF01000006_gene902 3.31e-30 110.0 COG3450@1|root,COG3450@2|Bacteria,1N21T@1224|Proteobacteria,2UWRC@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Protein of unknown function (DUF861) - - - - - - - - - - - - Cupin_3 k59_36630_1 67352.JODS01000015_gene7031 8.53e-46 160.0 COG0010@1|root,COG0010@2|Bacteria,2H81I@201174|Actinobacteria 201174|Actinobacteria E Belongs to the arginase family - - 3.5.3.1 ko:K01476 ko00220,ko00330,ko01100,ko01110,ko01130,ko01230,ko05146,map00220,map00330,map01100,map01110,map01130,map01230,map05146 M00029,M00134 R00551 RC00024,RC00329 ko00000,ko00001,ko00002,ko01000 - - - Arginase k59_1164495_1 84531.JMTZ01000021_gene3718 1.94e-18 81.6 COG0745@1|root,COG0745@2|Bacteria,1MU67@1224|Proteobacteria,1RNWH@1236|Gammaproteobacteria,1X3RN@135614|Xanthomonadales 135614|Xanthomonadales T Transcriptional regulatory protein, C terminal - - - ko:K02483 - - - - ko00000,ko02022 - - - Response_reg,Trans_reg_C k59_601145_1 316407.4062422 5.71e-86 263.0 COG2133@1|root,COG2133@2|Bacteria,1MV2E@1224|Proteobacteria,1RNGN@1236|Gammaproteobacteria,3XMGG@561|Escherichia 1236|Gammaproteobacteria G Can oxidize glucose to gluconolactone. Can also utilize D-arabinose, L- arabinose and 2-deoxy-glucose. Has higher activity towards oligomeric sugars, such as maltose, maltotriose or cellobiose. It may function to input sugar-derived electrons into the respiratory network yliI GO:0003674,GO:0003824,GO:0005488,GO:0005509,GO:0005575,GO:0005623,GO:0008150,GO:0008152,GO:0016491,GO:0016614,GO:0016901,GO:0019842,GO:0030288,GO:0030313,GO:0031406,GO:0031975,GO:0036094,GO:0042597,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0044464,GO:0046872,GO:0048037,GO:0048038,GO:0055114,GO:0070968,GO:0097159,GO:1901363 - ko:K21430 - - - - ko00000,ko01000 - - iSbBS512_1146.SbBS512_E2507 GSDH k59_1781181_1 1003200.AXXA_20137 3.65e-26 107.0 COG0042@1|root,COG0042@2|Bacteria,1MUY1@1224|Proteobacteria,2VHCA@28216|Betaproteobacteria,3T1T4@506|Alcaligenaceae 28216|Betaproteobacteria J Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U20 and U20a in tRNAs dusA - - ko:K05539 - - - - ko00000,ko01000,ko03016 - - - Dus k59_1781181_2 658187.LDG_8386 3.58e-14 71.2 COG0623@1|root,COG0623@2|Bacteria,1N64Z@1224|Proteobacteria,1T3N8@1236|Gammaproteobacteria,1JC7V@118969|Legionellales 118969|Legionellales I KR domain - - 1.3.1.104 ko:K10780 ko00061,ko01100,ko01212,map00061,map01100,map01212 M00083 R01404,R04430,R04725,R04956,R04959,R04962,R04967,R04970 RC00052,RC00076,RC00120 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 k59_1444031_1 96561.Dole_2296 1.09e-92 279.0 COG3264@1|root,COG3264@2|Bacteria,1QUBW@1224|Proteobacteria,43BRN@68525|delta/epsilon subdivisions,2X72H@28221|Deltaproteobacteria 28221|Deltaproteobacteria M Mechanosensitive ion channel - - - ko:K03442 - - - - ko00000,ko02000 1.A.23.2 - - MS_channel,TM_helix k59_714215_1 105559.Nwat_1431 2.47e-51 180.0 COG1196@1|root,COG1196@2|Bacteria,1MUAQ@1224|Proteobacteria,1RNA6@1236|Gammaproteobacteria,1WW7V@135613|Chromatiales 135613|Chromatiales D Required for chromosome condensation and partitioning smc - - ko:K03529 - - - - ko00000,ko03036 - - - SMC_N,SMC_hinge k59_714215_2 1123519.PSJM300_16300 6.48e-16 79.3 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,1RMH0@1236|Gammaproteobacteria,1Z2CU@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria NT Methyl-accepting chemotaxis protein - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - CZB,HAMP,MCPsignal,dCache_3 k59_1728975_1 1209072.ALBT01000008_gene2983 0.000868 39.3 COG3130@1|root,COG3130@2|Bacteria,1N761@1224|Proteobacteria,1SCIC@1236|Gammaproteobacteria,1FHIS@10|Cellvibrio 1236|Gammaproteobacteria J During stationary phase, converts 70S ribosomes to an inactive dimeric form (100S ribosomes) rmf GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006412,GO:0006417,GO:0006518,GO:0006807,GO:0006950,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0017148,GO:0019222,GO:0019538,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032055,GO:0032268,GO:0032269,GO:0033554,GO:0034248,GO:0034249,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043024,GO:0043043,GO:0043170,GO:0043555,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044464,GO:0044877,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0051716,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:2000112,GO:2000113 - ko:K03812 - - - - ko00000,ko03009 - - - RMF k59_1728975_2 382245.ASA_1995 6.17e-30 119.0 COG0116@1|root,COG1092@1|root,COG0116@2|Bacteria,COG1092@2|Bacteria,1MUQM@1224|Proteobacteria,1RNMH@1236|Gammaproteobacteria,1Y3HV@135624|Aeromonadales 135624|Aeromonadales J Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA rlmL - 2.1.1.173,2.1.1.264 ko:K12297 - - R07234 RC00003 ko00000,ko01000,ko03009 - - - Methyltrans_SAM,THUMP,UPF0020 k59_427758_1 316407.85677047 1.81e-65 208.0 COG1363@1|root,COG1363@2|Bacteria,1MXEU@1224|Proteobacteria,1RYRZ@1236|Gammaproteobacteria,3XN5P@561|Escherichia 1236|Gammaproteobacteria G Has a broad aminopeptidase activity on non-blocked peptides by progressively cleaving amino acids off the peptide substrate. Aminopeptidase activity stops at the residue before the first proline in the peptide. Cannot cleave when proline is the first N-terminal residue sgcX GO:0003674,GO:0003824,GO:0004177,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0008238,GO:0016787,GO:0019538,GO:0043170,GO:0044238,GO:0070011,GO:0071704,GO:0140096,GO:1901564 - ko:K18530,ko:K20609 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M42 k59_1392917_1 867845.KI911784_gene3377 2.02e-16 82.4 COG0577@1|root,COG0577@2|Bacteria,2G6IW@200795|Chloroflexi,374ZQ@32061|Chloroflexia 32061|Chloroflexia V MacB-like periplasmic core domain - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_1283095_2 177439.DP2932 3e-10 62.0 COG0037@1|root,COG0037@2|Bacteria,1MU85@1224|Proteobacteria,42NF0@68525|delta/epsilon subdivisions,2WIJK@28221|Deltaproteobacteria,2MHPA@213118|Desulfobacterales 28221|Deltaproteobacteria D Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine tilS - 6.3.4.19 ko:K04075 - - R09597 RC02633,RC02634 ko00000,ko01000,ko03016 - - - ATP_bind_3,TilS,TilS_C k59_1572012_1 395495.Lcho_1237 1.29e-39 145.0 COG0196@1|root,COG0196@2|Bacteria,1MV9I@1224|Proteobacteria,2VHIP@28216|Betaproteobacteria,1KIYV@119065|unclassified Burkholderiales 28216|Betaproteobacteria H Belongs to the ribF family ribF - 2.7.1.26,2.7.7.2 ko:K11753 ko00740,ko01100,ko01110,map00740,map01100,map01110 M00125 R00161,R00549 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - FAD_syn,Flavokinase k59_270380_1 1280390.CBQR020000065_gene1379 3.4e-07 58.2 COG1721@1|root,COG1721@2|Bacteria,1TUWF@1239|Firmicutes,4HDRE@91061|Bacilli,26RA4@186822|Paenibacillaceae 91061|Bacilli S conserved protein (some members contain a von Willebrand factor type A (vWA) domain) - - - - - - - - - - - - DUF58 k59_1283111_1 1229909.NSED_08735 1.31e-43 148.0 COG2429@1|root,arCOG04202@2157|Archaea,41SHK@651137|Thaumarchaeota 651137|Thaumarchaeota F Catalyzes the formation of 2-amino-5-formylamino-6- ribofuranosylamino-4(3H)-pyrimidinone ribonucleotide monophosphate and inorganic phosphate from GTP. Also has an independent pyrophosphate phosphohydrolase activity gch3 - 3.5.4.29 ko:K08096 ko00740,ko01100,map00740,map01100 - R07306 RC01790 ko00000,ko00001,ko01000 - - - GCH_III k59_1283111_2 436308.Nmar_1613 2.26e-29 114.0 COG0402@1|root,arCOG00692@2157|Archaea,41S61@651137|Thaumarchaeota 651137|Thaumarchaeota F Amidohydrolase family - - - - - - - - - - - - Amidohydro_1 k59_1572023_1 946077.W5A_01025 3.44e-125 363.0 COG0332@1|root,COG0332@2|Bacteria,4NEYH@976|Bacteroidetes,1HX72@117743|Flavobacteriia 976|Bacteroidetes I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids fabH GO:0003674,GO:0003824,GO:0006082,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0009987,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0032787,GO:0033818,GO:0043436,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0071704 2.3.1.180 ko:K00648 ko00061,ko01100,ko01212,map00061,map01100,map01212 M00082,M00083 R10707 RC00004,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - ACP_syn_III,ACP_syn_III_C k59_155451_1 436308.Nmar_0506 1.07e-121 350.0 arCOG03119@1|root,arCOG03119@2157|Archaea,41T0Y@651137|Thaumarchaeota 651137|Thaumarchaeota S PFAM SNARE associated Golgi protein - - - - - - - - - - - - - k59_155451_2 1229909.NSED_02545 2.14e-30 113.0 COG1418@1|root,arCOG01860@2157|Archaea,41T2N@651137|Thaumarchaeota 651137|Thaumarchaeota S Metal dependent phosphohydrolases with conserved 'HD' motif. - - - ko:K06950 - - - - ko00000 - - - HD k59_491953_1 1123034.JMKP01000002_gene1930 4.69e-37 125.0 COG0227@1|root,COG0227@2|Bacteria,1MZ57@1224|Proteobacteria,1S8UG@1236|Gammaproteobacteria,3NNZ1@468|Moraxellaceae 1236|Gammaproteobacteria J Belongs to the bacterial ribosomal protein bL28 family rpmB GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02902 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L28 k59_491953_2 550540.Fbal_0134 6.85e-20 80.9 COG0267@1|root,COG0267@2|Bacteria,1N6QV@1224|Proteobacteria,1SCEJ@1236|Gammaproteobacteria 1236|Gammaproteobacteria J Belongs to the bacterial ribosomal protein bL33 family rpmG GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042221,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046677,GO:0050896,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02913 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L33 k59_944536_1 247633.GP2143_17666 4.06e-56 187.0 COG1082@1|root,COG1082@2|Bacteria,1RAC3@1224|Proteobacteria,1RS39@1236|Gammaproteobacteria 1236|Gammaproteobacteria G Xylose isomerase - - - - - - - - - - - - AP_endonuc_2 k59_1452961_1 1137281.D778_02487 2.82e-154 437.0 COG0330@1|root,COG0330@2|Bacteria,4NEBV@976|Bacteroidetes,1HZ2R@117743|Flavobacteriia 976|Bacteroidetes O Membrane protease subunits, stomatin prohibitin homologs - - - - - - - - - - - - Band_7 k59_1624773_1 1123400.KB904769_gene2775 2.24e-109 334.0 COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,1RR14@1236|Gammaproteobacteria 1236|Gammaproteobacteria I COG0365 Acyl-coenzyme A synthetases AMP-(fatty) acid ligases prpE - 6.2.1.17 ko:K01908 ko00640,ko01100,map00640,map01100 - R00926,R01354 RC00004,RC00043,RC00070,RC02816 ko00000,ko00001,ko01000,ko01004 - - - ACAS_N,AMP-binding,AMP-binding_C k59_100840_1 396588.Tgr7_1112 1.32e-10 63.5 COG1502@1|root,COG1502@2|Bacteria,1MXA6@1224|Proteobacteria,1RZZ7@1236|Gammaproteobacteria 1236|Gammaproteobacteria I COG1502 Phosphatidylserine phosphatidylglycerophosphate cardiolipi n synthases and related enzymes - - - - - - - - - - - - PLDc_2 k59_723523_1 118005.AWNK01000003_gene2371 2.32e-67 221.0 COG0119@1|root,COG0119@2|Bacteria 2|Bacteria E Belongs to the alpha-IPM synthase homocitrate synthase family cimA - 2.3.3.13 ko:K01649 ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230 M00432 R01213 RC00004,RC00470,RC02754 br01601,ko00000,ko00001,ko00002,ko01000 - - - HMGL-like,LeuA_dimer k59_1452971_1 247634.GPB2148_3337 1.92e-37 137.0 COG1309@1|root,COG1309@2|Bacteria,1N6HV@1224|Proteobacteria,1SBC8@1236|Gammaproteobacteria,1JB1S@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria K Transcriptional regulator, TetR family - - - - - - - - - - - - TetR_C_2,TetR_C_6,TetR_N k59_1283143_1 420324.KI911948_gene9333 7.89e-46 157.0 COG0346@1|root,COG0346@2|Bacteria,1MUWY@1224|Proteobacteria,2TTMJ@28211|Alphaproteobacteria,1JXR1@119045|Methylobacteriaceae 28211|Alphaproteobacteria E Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily xylE - 1.13.11.2 ko:K00446 ko00361,ko00362,ko00622,ko00643,ko01100,ko01120,ko01220,map00361,map00362,map00622,map00643,map01100,map01120,map01220 M00569 R00816,R04089,R05295,R05404,R05406,R07795 RC00387,RC00643,RC01075,RC01364,RC01914 br01602,ko00000,ko00001,ko00002,ko01000 - - - Glyoxalase k59_1283143_2 309801.trd_0905 4.28e-27 105.0 COG0684@1|root,COG0684@2|Bacteria,2G8I8@200795|Chloroflexi,27YDY@189775|Thermomicrobia 189775|Thermomicrobia H Aldolase/RraA - - 4.1.3.17 ko:K10218 ko00362,ko00660,ko01120,map00362,map00660,map01120 - R00008,R00350 RC00067,RC00502,RC01205 ko00000,ko00001,ko01000 - - - RraA-like k59_723528_1 356851.JOAN01000006_gene377 1.68e-28 108.0 2B0UM@1|root,31T78@2|Bacteria,2GRW2@201174|Actinobacteria,4DFNG@85008|Micromonosporales 201174|Actinobacteria - - - - - - - - - - - - - - - k59_723528_3 1122138.AQUZ01000004_gene1043 1.75e-20 86.3 2B2ME@1|root,31V6V@2|Bacteria,2GPAB@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - - k59_662559_1 383381.EH30_08300 1.39e-18 81.6 COG0454@1|root,COG0456@2|Bacteria,1RIE6@1224|Proteobacteria,2UF5C@28211|Alphaproteobacteria,2K616@204457|Sphingomonadales 204457|Sphingomonadales K Acetyltransferase rimI - 2.3.1.128 ko:K03789 - - - - ko00000,ko01000,ko03009 - - - Acetyltransf_1,Acetyltransf_10 k59_1000294_2 1394178.AWOO02000020_gene7521 1.16e-30 117.0 COG0846@1|root,COG0846@2|Bacteria,2GJI3@201174|Actinobacteria,4EIS8@85012|Streptosporangiales 201174|Actinobacteria K Sir2 family cobB2 - - ko:K12410 - - - - ko00000,ko01000 - - - SIR2 k59_1514780_1 246197.MXAN_2658 3.55e-120 365.0 COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,42M51@68525|delta/epsilon subdivisions,2WIVD@28221|Deltaproteobacteria 28221|Deltaproteobacteria NU General secretory system II, protein E domain protein pulE-3 - - ko:K02454 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - T2SSE,T2SSE_N k59_1114239_1 485915.Dret_1575 1.62e-76 241.0 COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,42WT2@68525|delta/epsilon subdivisions,2WR9X@28221|Deltaproteobacteria,2MAU1@213115|Desulfovibrionales 28221|Deltaproteobacteria L PFAM transposase IS116 IS110 IS902 family protein - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_1624791_1 28229.ND2E_4327 3.07e-18 89.4 COG1629@1|root,COG4771@2|Bacteria,1MWKN@1224|Proteobacteria,1RRXB@1236|Gammaproteobacteria,2Q64Q@267889|Colwelliaceae 1236|Gammaproteobacteria P TonB dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_212525_1 380358.XALC_0614 3.42e-77 236.0 COG0353@1|root,COG0353@2|Bacteria,1MV9Q@1224|Proteobacteria,1RN99@1236|Gammaproteobacteria,1X30Z@135614|Xanthomonadales 135614|Xanthomonadales L May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO recR - - ko:K06187 ko03440,map03440 - - - ko00000,ko00001,ko03400 - - - RecR,Toprim_4 k59_1000297_1 1122137.AQXF01000007_gene3525 9.1e-159 460.0 COG1053@1|root,COG1053@2|Bacteria,1MU5M@1224|Proteobacteria,2TQJA@28211|Alphaproteobacteria 28211|Alphaproteobacteria C Belongs to the FAD-dependent oxidoreductase 2 family. FRD SDH subfamily sdhA - 1.3.5.1,1.3.5.4 ko:K00239 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134 M00009,M00011,M00149,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,Succ_DH_flav_C k59_1000297_2 454957.IA64_09080 1.89e-11 62.8 COG0479@1|root,COG0479@2|Bacteria,1MVHS@1224|Proteobacteria,1RNWR@1236|Gammaproteobacteria,1X3D9@135614|Xanthomonadales 135614|Xanthomonadales C Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family sdhB - 1.3.5.1,1.3.5.4 ko:K00240 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00149,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 - - - Fer2_3,Fer4_17 k59_1514784_1 861299.J421_3996 8.65e-30 121.0 COG2954@1|root,COG5607@1|root,COG2954@2|Bacteria,COG5607@2|Bacteria,1ZTYF@142182|Gemmatimonadetes 142182|Gemmatimonadetes S CYTH - - - - - - - - - - - - CHAD k59_547421_1 553385.JEMF01000010_gene2307 1.9e-23 102.0 COG0168@1|root,COG0168@2|Bacteria,1MUIJ@1224|Proteobacteria,1RMN6@1236|Gammaproteobacteria,1XHSI@135619|Oceanospirillales 135619|Oceanospirillales P Trk system potassium uptake protein trkH - - ko:K03498 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - - TrkH k59_1115464_1 1173023.KE650771_gene1532 1.07e-20 96.7 COG1262@1|root,COG5635@1|root,COG1262@2|Bacteria,COG5635@2|Bacteria,1G2I8@1117|Cyanobacteria 1117|Cyanobacteria T Signal transduction protein with nacht domain - - - - - - - - - - - - FGE-sulfatase,GUN4,NACHT k59_102061_1 702113.PP1Y_AT6284 5.72e-82 253.0 COG1195@1|root,COG1195@2|Bacteria,1MX8N@1224|Proteobacteria,2TQRD@28211|Alphaproteobacteria,2K0WV@204457|Sphingomonadales 204457|Sphingomonadales L it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP recF - - ko:K03629 ko03440,map03440 - - - ko00000,ko00001,ko03400 - - - SMC_N k59_213781_1 1532558.JL39_17425 3.68e-09 57.8 COG0745@1|root,COG0745@2|Bacteria,1MY3D@1224|Proteobacteria,2TTKG@28211|Alphaproteobacteria,4BAPT@82115|Rhizobiaceae 28211|Alphaproteobacteria T Transcriptional regulatory protein - - - ko:K02483 - - - - ko00000,ko02022 - - - Response_reg,Trans_reg_C k59_213781_2 1047013.AQSP01000140_gene2487 3.4e-09 57.8 COG1980@1|root,COG1980@2|Bacteria,2NNXV@2323|unclassified Bacteria 2|Bacteria G Fructose-1,6-bisphosphatase fbp - 3.1.3.11,4.1.2.13 ko:K01622 ko00010,ko00030,ko00051,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map01100,map01110,map01120,map01130,map01200,map01230 M00003 R00762,R01068,R01070,R02568,R04780 RC00017,RC00438,RC00439 ko00000,ko00001,ko00002,ko01000 - - - FBPase_3 k59_894879_1 316407.1651583 1.74e-114 341.0 COG3067@1|root,COG3067@2|Bacteria,1MV0F@1224|Proteobacteria,1RPE3@1236|Gammaproteobacteria,3XNNA@561|Escherichia 1236|Gammaproteobacteria P Na( ) H( ) antiporter that extrudes sodium in exchange for external protons nhaB GO:0003674,GO:0005215,GO:0005451,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006814,GO:0006873,GO:0006885,GO:0008150,GO:0008324,GO:0009987,GO:0010035,GO:0010038,GO:0010226,GO:0015075,GO:0015077,GO:0015078,GO:0015081,GO:0015291,GO:0015297,GO:0015298,GO:0015299,GO:0015318,GO:0015385,GO:0015491,GO:0015672,GO:0016020,GO:0019725,GO:0022804,GO:0022857,GO:0022890,GO:0030001,GO:0030003,GO:0030004,GO:0030641,GO:0034220,GO:0035725,GO:0042221,GO:0042592,GO:0044464,GO:0045851,GO:0046873,GO:0048878,GO:0050801,GO:0050896,GO:0051179,GO:0051234,GO:0051452,GO:0051453,GO:0055067,GO:0055080,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:0098771,GO:0099516,GO:1902600 - ko:K03314 - - - - ko00000,ko02000 2.A.34.1 - iECP_1309.ECP_1229,iLF82_1304.LF82_1485,iNRG857_1313.NRG857_06055,iUTI89_1310.UTI89_C1372 NhaB k59_1403425_1 448385.sce5989 3.92e-42 149.0 COG1968@1|root,COG1968@2|Bacteria,1MX02@1224|Proteobacteria,42N67@68525|delta/epsilon subdivisions,2WKPK@28221|Deltaproteobacteria,2Z316@29|Myxococcales 28221|Deltaproteobacteria V Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin uppP - 3.6.1.27 ko:K06153 ko00550,map00550 - R05627 RC00002 ko00000,ko00001,ko01000,ko01011 - - - BacA k59_1573258_1 521719.ATXQ01000002_gene2429 1.49e-17 79.7 2AQI0@1|root,31FQP@2|Bacteria,1RI31@1224|Proteobacteria,1TAV2@1236|Gammaproteobacteria,1YGKQ@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_1573258_2 663321.REG_1197 1.36e-45 151.0 COG0245@1|root,COG0245@2|Bacteria,1MVHA@1224|Proteobacteria,1S3RQ@1236|Gammaproteobacteria,282RI@191675|unclassified Enterobacteriaceae 1236|Gammaproteobacteria I Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) ispF GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0008270,GO:0008685,GO:0009058,GO:0009108,GO:0009987,GO:0016829,GO:0016849,GO:0030145,GO:0042180,GO:0042181,GO:0042802,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901661,GO:1901663 4.6.1.12 ko:K01770 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05637 RC00002,RC01440 ko00000,ko00001,ko00002,ko01000 - - iPC815.YPO3360 YgbB k59_1790914_1 1415778.JQMM01000001_gene1271 2.18e-51 175.0 COG0628@1|root,COG0628@2|Bacteria,1MXXU@1224|Proteobacteria,1RQCM@1236|Gammaproteobacteria,1J4EG@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S AI-2E family transporter tqsA GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0009372,GO:0009987,GO:0015562,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0044764,GO:0051179,GO:0051234,GO:0051704,GO:0055085,GO:0071944 - ko:K11744 - - - - ko00000 - - - AI-2E_transport k59_548510_1 1122137.AQXF01000001_gene3378 5.53e-134 382.0 COG0177@1|root,COG0177@2|Bacteria,1MUYQ@1224|Proteobacteria,2TRI2@28211|Alphaproteobacteria 28211|Alphaproteobacteria L DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate nth - 4.2.99.18 ko:K10773 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - EndIII_4Fe-2S,HhH-GPD k59_548510_2 1122137.AQXF01000001_gene3377 2.03e-92 275.0 COG1073@1|root,COG1073@2|Bacteria,1MX88@1224|Proteobacteria,2TSRE@28211|Alphaproteobacteria 28211|Alphaproteobacteria S hydrolases or acyltransferases (alpha beta hydrolase superfamily) MA20_24420 - - ko:K06889 - - - - ko00000 - - - Abhydrolase_6,Hydrolase_4 k59_329700_1 1323663.AROI01000016_gene488 5.21e-25 103.0 COG0593@1|root,COG0593@2|Bacteria,1MVW6@1224|Proteobacteria,1RPJP@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Mediates the interaction of DNA replication inititator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinititation, a process called regulatory inhibition of DnaA or RIDA hda GO:0000166,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006275,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008156,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010556,GO:0010558,GO:0010605,GO:0016020,GO:0017076,GO:0019219,GO:0019222,GO:0030174,GO:0030554,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032297,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0043531,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0045934,GO:0046483,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051052,GO:0051053,GO:0051171,GO:0051172,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0090329,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901363,GO:1901576,GO:2000104,GO:2000112,GO:2000113 - ko:K10763 - - - - ko00000,ko03032 - - - Bac_DnaA k59_1573267_1 95619.PM1_0229175 4.07e-06 54.3 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria 1236|Gammaproteobacteria T Diguanylate cyclase - - - - - - - - - - - - EAL,GGDEF,PAS_3,Protoglobin k59_102095_1 1033736.CAHK01000033_gene1091 1.67e-39 152.0 COG1132@1|root,COG1132@2|Bacteria,2GITR@201174|Actinobacteria,4F8E0@85019|Brevibacteriaceae 201174|Actinobacteria V ABC transporter transmembrane region - - - ko:K06147 - - - - ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran k59_1681295_1 1229909.NSED_01450 1.49e-47 160.0 COG3958@1|root,arCOG01051@2157|Archaea,41SEP@651137|Thaumarchaeota 651137|Thaumarchaeota G Transketolase, pyrimidine binding domain - - 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 - - - Transket_pyr,Transketolase_C k59_1681295_2 1229909.NSED_01455 1.65e-74 228.0 COG0176@1|root,arCOG05061@2157|Archaea,41S99@651137|Thaumarchaeota 651137|Thaumarchaeota G Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway tal - 2.2.1.2 ko:K00616 ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007 R01827 RC00439,RC00604 ko00000,ko00001,ko00002,ko01000 - - - TAL_FSA k59_1738523_1 203122.Sde_0823 3.26e-57 185.0 COG1595@1|root,COG1595@2|Bacteria,1RKMN@1224|Proteobacteria,1S76R@1236|Gammaproteobacteria 1236|Gammaproteobacteria K Belongs to the sigma-70 factor family. ECF subfamily - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 k59_329720_1 322710.Avin_37060 1.65e-44 164.0 COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,1RN3H@1236|Gammaproteobacteria 1236|Gammaproteobacteria KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance relA GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008728,GO:0008893,GO:0009116,GO:0009117,GO:0009119,GO:0009150,GO:0009259,GO:0009605,GO:0009987,GO:0009991,GO:0015949,GO:0015969,GO:0016020,GO:0016740,GO:0016772,GO:0016778,GO:0016787,GO:0016788,GO:0016794,GO:0019637,GO:0019693,GO:0030312,GO:0031667,GO:0033865,GO:0033875,GO:0034032,GO:0034035,GO:0034641,GO:0042278,GO:0042578,GO:0042594,GO:0044237,GO:0044238,GO:0044281,GO:0044464,GO:0046128,GO:0046483,GO:0050896,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:1901068,GO:1901135,GO:1901360,GO:1901564,GO:1901657 2.7.6.5 ko:K00951 ko00230,map00230 - R00429 RC00002,RC00078 ko00000,ko00001,ko01000 - - iSFV_1184.SFV_2673 ACT_4,HD_4,RelA_SpoT,TGS k59_1738533_1 1229909.NSED_01200 6.31e-60 186.0 COG2142@1|root,arCOG04162@2157|Archaea,41SRA@651137|Thaumarchaeota 651137|Thaumarchaeota C Succinate dehydrogenase/Fumarate reductase transmembrane subunit - - - ko:K00242 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00149,M00173 R02164 RC00045 ko00000,ko00001,ko00002 - - - Sdh_cyt k59_945606_1 702113.PP1Y_AT17003 1.21e-117 341.0 COG0090@1|root,COG0090@2|Bacteria,1MVTD@1224|Proteobacteria,2TTKD@28211|Alphaproteobacteria,2JZZY@204457|Sphingomonadales 204457|Sphingomonadales J One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity rplB - - ko:K02886 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L2,Ribosomal_L2_C k59_1681312_1 351348.Maqu_0525 1.03e-24 102.0 COG0606@1|root,COG0606@2|Bacteria,1MU4R@1224|Proteobacteria,1RMB9@1236|Gammaproteobacteria,464ZX@72275|Alteromonadaceae 1236|Gammaproteobacteria O ATPase with chaperone activity comM - - ko:K07391 - - - - ko00000 - - - ChlI,Mg_chelatase,Mg_chelatase_C k59_1681312_2 93220.LV28_16715 4.33e-16 72.4 COG2960@1|root,COG2960@2|Bacteria,1N7AH@1224|Proteobacteria,2VVR4@28216|Betaproteobacteria,1K9GB@119060|Burkholderiaceae 28216|Betaproteobacteria S Membrane fusogenic activity yqiC - - ko:K09806 - - - - ko00000 - - - BMFP k59_1738540_1 1150626.PHAMO_230074 1.01e-06 50.4 COG2022@1|root,COG2104@1|root,COG2022@2|Bacteria,COG2104@2|Bacteria,1N0N5@1224|Proteobacteria,2TSXS@28211|Alphaproteobacteria,2JPMG@204441|Rhodospirillales 204441|Rhodospirillales H Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S thiG - 2.8.1.10 ko:K03149 ko00730,ko01100,map00730,map01100 - R10247 RC03096,RC03097,RC03461 ko00000,ko00001,ko01000 - - - ThiG,ThiS k59_1738540_2 67275.JOAP01000019_gene1432 1.4e-20 86.7 COG0757@1|root,COG0757@2|Bacteria,2IMBY@201174|Actinobacteria 201174|Actinobacteria E Catalyzes a trans-dehydration via an enolate intermediate aroQ - 4.2.1.10 ko:K03786 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R03084 RC00848 ko00000,ko00001,ko00002,ko01000 - - - DHquinase_II k59_548557_1 983545.Glaag_2832 1.31e-52 180.0 COG0583@1|root,COG0583@2|Bacteria,1MX2A@1224|Proteobacteria,1RQ5Y@1236|Gammaproteobacteria,46BI8@72275|Alteromonadaceae 1236|Gammaproteobacteria K Bacterial regulatory helix-turn-helix protein, lysR family nocR - - - - - - - - - - - HTH_1,LysR_substrate k59_548557_2 1500897.JQNA01000002_gene643 2.47e-20 93.2 COG0665@1|root,COG0665@2|Bacteria,1MVIZ@1224|Proteobacteria,2VHQJ@28216|Betaproteobacteria,1K0CF@119060|Burkholderiaceae 28216|Betaproteobacteria C D-amino acid dehydrogenase - - 1.4.5.1 ko:K00285 ko00360,map00360 - R01374,R09493 RC00006,RC00025 ko00000,ko00001,ko01000 - - - DAO k59_1790950_1 702113.PP1Y_Mpl10172 2.28e-70 238.0 COG3250@1|root,COG3250@2|Bacteria,1P9KJ@1224|Proteobacteria,2UZ0A@28211|Alphaproteobacteria,2K315@204457|Sphingomonadales 204457|Sphingomonadales G alpha-L-rhamnosidase - - - - - - - - - - - - Glyco_hydro_106 k59_1738557_1 1335757.SPICUR_01450 6.55e-39 140.0 COG0232@1|root,COG0232@2|Bacteria,1MVQ2@1224|Proteobacteria,1RPVJ@1236|Gammaproteobacteria 1236|Gammaproteobacteria F dGTPase preferentially hydrolyzes dGTP over the other canonical NTPs dgt GO:0003674,GO:0003824,GO:0006139,GO:0006163,GO:0006195,GO:0006203,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008832,GO:0009056,GO:0009058,GO:0009117,GO:0009141,GO:0009143,GO:0009144,GO:0009146,GO:0009151,GO:0009155,GO:0009166,GO:0009200,GO:0009204,GO:0009215,GO:0009217,GO:0009262,GO:0009264,GO:0009394,GO:0009987,GO:0015949,GO:0016787,GO:0016788,GO:0016793,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042578,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046070,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576 3.1.5.1 ko:K01129 ko00230,map00230 - R01856 RC00017 ko00000,ko00001,ko01000 - - - HD,HD_assoc k59_1790952_1 266264.Rmet_1732 3.57e-13 74.3 COG2207@1|root,COG2207@2|Bacteria,1MX23@1224|Proteobacteria,2VTT4@28216|Betaproteobacteria 28216|Betaproteobacteria K Arabinose-binding domain of AraC transcription regulator, N-term - - - - - - - - - - - - Arabinose_bd,HTH_18 k59_663779_2 1346791.M529_12730 2.92e-35 135.0 COG0015@1|root,COG0015@2|Bacteria,1MV4B@1224|Proteobacteria,2TQUE@28211|Alphaproteobacteria,2K0GV@204457|Sphingomonadales 204457|Sphingomonadales F Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily purB - 4.3.2.2 ko:K01756 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048,M00049 R01083,R04559 RC00379,RC00444,RC00445 ko00000,ko00001,ko00002,ko01000 - - - ADSL_C,Lyase_1 k59_1115521_1 1122915.AUGY01000028_gene5954 4.52e-22 92.4 COG3677@1|root,COG3677@2|Bacteria,1V4D1@1239|Firmicutes,4HREI@91061|Bacilli 91061|Bacilli L ISXO2-like transposase domain - - - - - - - - - - - - DDE_Tnp_IS1595 k59_1454275_1 314231.FP2506_14824 2.12e-25 102.0 COG0247@1|root,COG0247@2|Bacteria,1MWTK@1224|Proteobacteria,2TR9H@28211|Alphaproteobacteria,2PKVV@255475|Aurantimonadaceae 28211|Alphaproteobacteria C Cysteine-rich domain - - - ko:K18928 - - - - ko00000 - - - CCG k59_1454275_2 1122194.AUHU01000001_gene6 6.67e-210 596.0 COG1139@1|root,COG1139@2|Bacteria,1MV6J@1224|Proteobacteria,1RQEA@1236|Gammaproteobacteria,465G6@72275|Alteromonadaceae 1236|Gammaproteobacteria C conserved protein containing a ferredoxin-like domain - - - ko:K18929 - - - - ko00000 - - - DUF3390,Fer4_17,Fer4_4,Fer4_7,Fer4_8,LUD_dom k59_213885_2 1283300.ATXB01000002_gene3114 1.58e-13 73.6 COG2132@1|root,COG2132@2|Bacteria,1QR33@1224|Proteobacteria,1SMFR@1236|Gammaproteobacteria,1XG58@135618|Methylococcales 135618|Methylococcales Q Multicopper oxidase - - - - - - - - - - - - Cu-oxidase_2,Cu-oxidase_3 k59_663793_2 471852.Tcur_1342 7.36e-59 184.0 COG0662@1|root,COG0662@2|Bacteria,2IMHT@201174|Actinobacteria,4EKA7@85012|Streptosporangiales 201174|Actinobacteria G Cupin 2, conserved barrel domain protein - - - - - - - - - - - - Cupin_2,EutQ k59_213888_1 1122137.AQXF01000002_gene156 1.15e-207 589.0 COG0147@1|root,COG0147@2|Bacteria,1MVBJ@1224|Proteobacteria,2TRWB@28211|Alphaproteobacteria 28211|Alphaproteobacteria EH Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia trpE - 4.1.3.27 ko:K01657 ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025 M00023 R00985,R00986 RC00010,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 - - - Anth_synt_I_N,Chorismate_bind k59_1174346_1 1144305.PMI02_01828 2.16e-97 294.0 COG1609@1|root,COG1609@2|Bacteria,1MW7E@1224|Proteobacteria,2TVGC@28211|Alphaproteobacteria,2K05K@204457|Sphingomonadales 204457|Sphingomonadales K LacI family - - - ko:K02529 - - - - ko00000,ko03000 - - - LacI,Peripla_BP_3 k59_1454279_1 1415778.JQMM01000001_gene843 7.5e-47 157.0 COG3105@1|root,COG3105@2|Bacteria,1N25P@1224|Proteobacteria,1SE1A@1236|Gammaproteobacteria,1J6VW@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S protein conserved in bacteria - - - ko:K09908 - - - - ko00000 - - - DUF1043 k59_437473_2 661478.OP10G_2237 1.21e-69 223.0 COG0304@1|root,COG0304@2|Bacteria 2|Bacteria I 3-oxoacyl-[acyl-carrier-protein] synthase activity fabF - 2.3.1.179 ko:K09458 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119 RC00039,RC02728,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Ketoacyl-synt_C,ketoacyl-synt k59_894934_1 1229909.NSED_02285 7.02e-99 293.0 COG2897@1|root,arCOG02019@2157|Archaea,41SZQ@651137|Thaumarchaeota 651137|Thaumarchaeota P Rhodanese Homology Domain - - 2.8.1.1,2.8.1.2 ko:K01011 ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122 - R01931,R03105,R03106 RC00214 ko00000,ko00001,ko01000 - - - Rhodanese k59_1230294_1 1196322.A370_04371 2.35e-05 46.2 COG0577@1|root,COG0577@2|Bacteria,1TPUU@1239|Firmicutes,2483J@186801|Clostridia,36ETV@31979|Clostridiaceae 186801|Clostridia V ABC-type antimicrobial peptide transport system, permease component - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_1230294_2 1123517.JOMR01000001_gene1359 9.24e-08 54.3 COG1555@1|root,COG1555@2|Bacteria,1N6Q3@1224|Proteobacteria,1SC7U@1236|Gammaproteobacteria,461EQ@72273|Thiotrichales 72273|Thiotrichales L TIGRFAM Competence protein ComEA, helix-hairpin-helix - - - ko:K02237 - M00429 - - ko00000,ko00002,ko02044 3.A.11.1,3.A.11.2 - - HHH_3 k59_1230294_3 1121472.AQWN01000002_gene2204 5.55e-38 134.0 COG0802@1|root,COG0802@2|Bacteria,1V6CV@1239|Firmicutes,24MSS@186801|Clostridia,2621R@186807|Peptococcaceae 186801|Clostridia S PFAM Uncharacterised P-loop hydrolase UPF0079 ydiB - - ko:K06925 - - - - ko00000,ko03016 - - - TsaE k59_1230294_4 521098.Aaci_0355 1.81e-16 81.3 COG0062@1|root,COG0063@1|root,COG0062@2|Bacteria,COG0063@2|Bacteria,1TNZE@1239|Firmicutes,4HBZC@91061|Bacilli 91061|Bacilli H Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration nnrD - 4.2.1.136,5.1.99.6 ko:K17758,ko:K17759 - - - - ko00000,ko01000 - - - Carb_kinase,YjeF_N k59_329763_1 1229909.NSED_02500 3.63e-81 242.0 COG0822@1|root,arCOG02077@2157|Archaea,41SPT@651137|Thaumarchaeota 651137|Thaumarchaeota C SUF system FeS assembly protein - - - ko:K04488 - - - - ko00000 - - - NifU_N k59_329763_2 1131266.ARWQ01000005_gene813 0.0005 41.2 arCOG08758@1|root,arCOG08758@2157|Archaea,41SVS@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_775260_2 396588.Tgr7_0655 9.81e-18 82.4 COG1262@1|root,COG1262@2|Bacteria,1Q227@1224|Proteobacteria,1RQEK@1236|Gammaproteobacteria,1WY4C@135613|Chromatiales 135613|Chromatiales S PFAM SapC - - - - - - - - - - - - SapC k59_775264_1 1396141.BATP01000042_gene1898 2.48e-59 196.0 COG0577@1|root,COG0577@2|Bacteria,46UT6@74201|Verrucomicrobia,2IVGX@203494|Verrucomicrobiae 203494|Verrucomicrobiae V MacB-like periplasmic core domain - - - - - - - - - - - - FtsX,MacB_PCD k59_1747537_2 411684.HPDFL43_02720 8.62e-52 175.0 COG2515@1|root,COG2515@2|Bacteria,1MVYF@1224|Proteobacteria,2TRCB@28211|Alphaproteobacteria,43PB8@69277|Phyllobacteriaceae 28211|Alphaproteobacteria E Pyridoxal-phosphate dependent enzyme - - 4.4.1.15,4.4.1.25 ko:K05396,ko:K17950 ko00270,map00270 - R01874,R07634 RC00382,RC01784 ko00000,ko00001,ko01000 - - - PALP k59_111497_1 344747.PM8797T_06160 4.3e-55 183.0 COG0535@1|root,COG0535@2|Bacteria,2J45Y@203682|Planctomycetes 203682|Planctomycetes C Iron-sulfur cluster-binding domain - - - - - - - - - - - - Radical_SAM,SPASM k59_1071813_1 1122137.AQXF01000005_gene1274 1.21e-72 238.0 COG4206@1|root,COG4206@2|Bacteria,1MW63@1224|Proteobacteria,2TT3G@28211|Alphaproteobacteria 28211|Alphaproteobacteria H receptor - - - ko:K16092 - - - - ko00000,ko02000 1.B.14.3 - - Plug,TonB_dep_Rec k59_165899_1 1122194.AUHU01000013_gene707 4.38e-45 159.0 COG1448@1|root,COG1448@2|Bacteria,1MUT0@1224|Proteobacteria,1RN02@1236|Gammaproteobacteria,4647G@72275|Alteromonadaceae 1236|Gammaproteobacteria E COG1448 Aspartate tyrosine aromatic aminotransferase phhC - 2.6.1.1,2.6.1.57 ko:K00813,ko:K00832 ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230 M00024,M00025,M00034,M00040 R00355,R00694,R00734,R00896,R01731,R02433,R02619,R05052,R07396,R10845 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 k59_954893_1 1121013.P873_09320 0.0004 42.0 COG0136@1|root,COG0136@2|Bacteria,1MUHG@1224|Proteobacteria,1RNB6@1236|Gammaproteobacteria,1X2X5@135614|Xanthomonadales 135614|Xanthomonadales E Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate asd - 1.2.1.11 ko:K00133 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00017,M00018,M00033,M00525,M00526,M00527 R02291 RC00684 ko00000,ko00001,ko00002,ko01000 - - - Semialdhyde_dh,Semialdhyde_dhC k59_954893_2 768066.HELO_2234 2.75e-92 281.0 COG0473@1|root,COG0473@2|Bacteria,1MUH4@1224|Proteobacteria,1RMZQ@1236|Gammaproteobacteria,1XH6T@135619|Oceanospirillales 135619|Oceanospirillales CE Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate leuB - 1.1.1.85 ko:K00052 ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230 M00432,M00535 R00994,R04426,R10052 RC00084,RC00417,RC03036 br01601,ko00000,ko00001,ko00002,ko01000 - - - Iso_dh k59_501851_1 203122.Sde_0590 7.84e-152 446.0 COG1082@1|root,COG1082@2|Bacteria,1NNTS@1224|Proteobacteria,1RP3I@1236|Gammaproteobacteria,465TX@72275|Alteromonadaceae 1236|Gammaproteobacteria G Glycosyl-hydrolase 97 N-terminal - - 3.2.1.20 ko:K01187 ko00052,ko00500,ko01100,map00052,map00500,map01100 - R00028,R00801,R00802,R06087,R06088 RC00028,RC00049,RC00077 ko00000,ko00001,ko01000 - GH31 - GH97_C,GH97_N,Glyco_hydro_97 k59_734054_2 272943.RSP_0384 4.66e-25 102.0 COG1073@1|root,COG1073@2|Bacteria,1MX88@1224|Proteobacteria,2TSRE@28211|Alphaproteobacteria,1FBNV@1060|Rhodobacter 28211|Alphaproteobacteria S Serine aminopeptidase, S33 MA20_24420 - - ko:K06889 - - - - ko00000 - - - Abhydrolase_6,Hydrolase_4 k59_1692298_1 580332.Slit_2994 7.31e-100 305.0 COG0706@1|root,COG0706@2|Bacteria,1MV5M@1224|Proteobacteria,2VHIA@28216|Betaproteobacteria,44V1I@713636|Nitrosomonadales 28216|Betaproteobacteria U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins yidC - - ko:K03217 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044,ko03029 2.A.9 - - 60KD_IMP,YidC_periplas k59_1801572_1 1122137.AQXF01000005_gene1102 1.8e-91 272.0 COG0164@1|root,COG0164@2|Bacteria,1RA65@1224|Proteobacteria,2U73X@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids rnhB GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006281,GO:0006298,GO:0006401,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0032299,GO:0032991,GO:0033554,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576 3.1.26.4 ko:K03470 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - RNase_HII k59_1465235_1 1192759.AKIB01000003_gene720 4.8e-130 381.0 COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,2TR15@28211|Alphaproteobacteria,2K16K@204457|Sphingomonadales 204457|Sphingomonadales I Acyl-CoA dehydrogenase, C-terminal domain - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_503505_1 313596.RB2501_06690 2.98e-22 93.6 2E3UQ@1|root,32YS1@2|Bacteria 2|Bacteria S PFAM sulfotransferase - - - - - - - - - - - - Sulfotransfer_1 k59_1295637_1 203122.Sde_2352 2.47e-117 352.0 COG0437@1|root,COG3302@1|root,COG0437@2|Bacteria,COG3302@2|Bacteria,1MU1B@1224|Proteobacteria,1SYHX@1236|Gammaproteobacteria,46DIM@72275|Alteromonadaceae 1236|Gammaproteobacteria C 4Fe-4S dicluster domain - - - ko:K07307 ko00920,map00920 - R09501 RC02555 ko00000,ko00001,ko02000 5.A.3.3 - - DmsC,Fer4_11,Fer4_4 k59_956555_1 313628.LNTAR_07936 5.66e-38 141.0 COG3385@1|root,COG3385@2|Bacteria 2|Bacteria L transposase activity - - - - - - - - - - - - DDE_Tnp_1 k59_167537_1 1122137.AQXF01000001_gene3184 6.05e-117 357.0 COG0280@1|root,COG0281@1|root,COG0280@2|Bacteria,COG0281@2|Bacteria,1MU0A@1224|Proteobacteria,2TQJT@28211|Alphaproteobacteria 28211|Alphaproteobacteria C Malic enzyme tme - 1.1.1.40 ko:K00029 ko00620,ko00710,ko01100,ko01120,ko01200,map00620,map00710,map01100,map01120,map01200 M00169,M00172 R00216 RC00105 ko00000,ko00001,ko00002,ko01000 - - - Malic_M,PTA_PTB,malic k59_1636965_1 1137799.GZ78_18885 4.1e-57 188.0 COG0739@1|root,COG0739@2|Bacteria,1MVTF@1224|Proteobacteria,1RMIR@1236|Gammaproteobacteria,1XIFQ@135619|Oceanospirillales 135619|Oceanospirillales M peptidase - - - - - - - - - - - - Peptidase_M23 k59_559444_1 1397696.KK211189_gene863 2.12e-05 53.1 COG5002@1|root,COG5002@2|Bacteria,1UY8K@1239|Firmicutes,4HTX2@91061|Bacilli 91061|Bacilli T Cache domain - - - - - - - - - - - - HATPase_c,HisKA,dCache_1 k59_1801595_2 1249627.D779_3188 2.08e-72 228.0 COG1192@1|root,COG1192@2|Bacteria,1N4FM@1224|Proteobacteria,1RSHR@1236|Gammaproteobacteria,1WXPF@135613|Chromatiales 135613|Chromatiales D Involved in chromosome partitioning - - - - - - - - - - - - - k59_559466_1 566466.NOR53_512 2.68e-106 321.0 COG3119@1|root,COG3119@2|Bacteria,1MUJH@1224|Proteobacteria,1RN2V@1236|Gammaproteobacteria,1J88Q@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P COG3119 Arylsulfatase A and related enzymes - - 3.1.6.1 ko:K01130 ko00140,ko00600,map00140,map00600 - R03980,R04856 RC00128,RC00231 ko00000,ko00001,ko01000 - - - Sulfatase,Sulfatase_C k59_1636995_1 377629.TERTU_0782 2.51e-72 240.0 28I5V@1|root,2Z891@2|Bacteria,1R3WS@1224|Proteobacteria,1RY0Y@1236|Gammaproteobacteria,2PN8W@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria S Cellulase N-terminal ig-like domain - - - - - - - - - - - - CelD_N,Glyco_hydro_9 k59_1012024_1 1220535.IMCC14465_00400 3.68e-17 84.3 COG1043@1|root,COG1043@2|Bacteria,1MUHQ@1224|Proteobacteria,2TRK9@28211|Alphaproteobacteria,4BPGW@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria M Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell lpxA - 2.3.1.129 ko:K00677 ko00540,ko01100,ko01503,map00540,map01100,map01503 M00060 R04567 RC00039,RC00055 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Acetyltransf_11,Hexapep k59_1012024_2 1158292.JPOE01000005_gene1278 3.54e-61 189.0 COG0316@1|root,COG0316@2|Bacteria,1RHCW@1224|Proteobacteria,2VR2M@28216|Betaproteobacteria,1KKSP@119065|unclassified Burkholderiales 28216|Betaproteobacteria C Required for insertion of 4Fe-4S clusters erpA - - ko:K15724 - - - - ko00000 - - - Fe-S_biosyn k59_1012035_1 1411123.JQNH01000001_gene3911 2.23e-125 369.0 COG3386@1|root,COG3386@2|Bacteria,1MU0C@1224|Proteobacteria,2TSXG@28211|Alphaproteobacteria 28211|Alphaproteobacteria G Gluconolactonase - - 3.1.1.17 ko:K01053,ko:K14274 ko00030,ko00040,ko00053,ko00930,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,map00030,map00040,map00053,map00930,map01100,map01110,map01120,map01130,map01200,map01220 M00129 R01519,R02427,R02933,R03751 RC00537,RC00713,RC00983 ko00000,ko00001,ko00002,ko01000,ko04147 - - - SGL k59_1184937_1 1156935.QWE_10062 2.11e-49 166.0 28I45@1|root,2Z87Q@2|Bacteria,1R432@1224|Proteobacteria,2U3PK@28211|Alphaproteobacteria,4BBK6@82115|Rhizobiaceae 28211|Alphaproteobacteria E NHase catalyzes the hydration of various nitrile compounds to the corresponding amides nthB - 4.2.1.84 ko:K20807 ko00364,ko00380,ko00627,ko00643,ko01120,map00364,map00380,map00627,map00643,map01120 - R04020,R05379,R05596,R07780,R07854 RC00483,RC01345,RC01432 ko00000,ko00001,ko01000 - - - NHase_beta k59_1012047_1 1131269.AQVV01000005_gene329 9.27e-22 99.0 COG0763@1|root,COG0763@2|Bacteria 2|Bacteria M lipid-A-disaccharide synthase activity lpxB GO:0003674,GO:0003824,GO:0005488,GO:0005543,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008194,GO:0008289,GO:0008610,GO:0008654,GO:0008915,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0019637,GO:0019897,GO:0019898,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0046467,GO:0046493,GO:0071704,GO:0071944,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 2.4.1.182 ko:K00748 ko00540,ko01100,map00540,map01100 M00060 R04606 RC00005,RC00059 ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT19 iE2348C_1286.E2348C_0187,iEcolC_1368.EcolC_3478,iIT341.HP0867 LpxB k59_674479_1 1449353.JQMQ01000005_gene5155 0.000983 45.1 COG1309@1|root,COG1309@2|Bacteria 2|Bacteria K transcriptional regulator - - - ko:K22107 - - - - ko00000,ko03000 - - - TetR_N k59_845748_1 658187.LDG_7174 0.000738 46.6 COG1680@1|root,COG1680@2|Bacteria 2|Bacteria V peptidase activity - - 3.4.16.4 ko:K01286 - - - - ko00000,ko01000 - - - Beta-lactamase,HemolysinCabind k59_786053_1 1134912.AJTV01000003_gene1583 4.77e-33 132.0 COG1858@1|root,COG1858@2|Bacteria,1MV70@1224|Proteobacteria,2TRTJ@28211|Alphaproteobacteria 28211|Alphaproteobacteria C cytochrome c peroxidase - - 1.11.1.5 ko:K00428 - - - - ko00000,ko01000 - - - CCP_MauG,Cytochrom_C k59_448383_1 1121022.ABENE_20735 2.02e-27 116.0 COG2425@1|root,COG2425@2|Bacteria,1QV44@1224|Proteobacteria,2TXST@28211|Alphaproteobacteria 28211|Alphaproteobacteria S protein containing a von Willebrand factor type A (vWA) domain - - - - - - - - - - - - - k59_1692420_1 861299.J421_1842 2.3e-34 133.0 COG0789@1|root,COG0789@2|Bacteria 2|Bacteria K bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding litR - 2.3.3.1 ko:K01647,ko:K22491 ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00740 R00351 RC00004,RC00067 br01601,ko00000,ko00001,ko00002,ko01000,ko03000 - - - B12-binding,B12-binding_2,MerR_1 k59_1012073_1 1122137.AQXF01000002_gene36 1.95e-50 166.0 COG1117@1|root,COG1117@2|Bacteria,1MU16@1224|Proteobacteria,2TQX9@28211|Alphaproteobacteria 28211|Alphaproteobacteria P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system pstB - 3.6.3.27 ko:K02036 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.7 - - ABC_tran k59_1012073_2 1122137.AQXF01000002_gene35 7.79e-67 209.0 COG0704@1|root,COG0704@2|Bacteria,1MUMI@1224|Proteobacteria,2TQMN@28211|Alphaproteobacteria 28211|Alphaproteobacteria P Plays a role in the regulation of phosphate uptake phoU GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009892,GO:0010563,GO:0010966,GO:0019220,GO:0019222,GO:0031323,GO:0031324,GO:0032879,GO:0034762,GO:0034763,GO:0034765,GO:0034766,GO:0042802,GO:0042803,GO:0043269,GO:0043271,GO:0044070,GO:0044424,GO:0044464,GO:0045936,GO:0046983,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051049,GO:0051051,GO:0051174,GO:0065007,GO:1903792,GO:1903795,GO:1903796,GO:1903959,GO:1903960,GO:2000185,GO:2000186 - ko:K02039 - - - - ko00000 - - - PhoU k59_167621_1 1123368.AUIS01000007_gene2741 1.86e-25 102.0 2F2KZ@1|root,33VHM@2|Bacteria,1NV1E@1224|Proteobacteria,1SN95@1236|Gammaproteobacteria,2NCKP@225057|Acidithiobacillales 225057|Acidithiobacillales - - - - - - - - - - - - - - - k59_167621_2 1288494.EBAPG3_4090 2.35e-69 214.0 COG0494@1|root,COG0494@2|Bacteria,1RDGJ@1224|Proteobacteria,2VIDX@28216|Betaproteobacteria,372CX@32003|Nitrosomonadales 28216|Betaproteobacteria L Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage nudH - - ko:K08311 ko03018,map03018 - R10816 RC00002 ko00000,ko00001,ko01000,ko03019 - - - NUDIX k59_674504_1 1161401.ASJA01000001_gene473 2.69e-80 247.0 COG1028@1|root,COG1028@2|Bacteria,1MXNQ@1224|Proteobacteria,2TS6G@28211|Alphaproteobacteria,43W8V@69657|Hyphomonadaceae 28211|Alphaproteobacteria IQ Belongs to the short-chain dehydrogenases reductases (SDR) family MA20_27450 - - - - - - - - - - - adh_short k59_559545_1 234267.Acid_2148 8.41e-08 59.3 COG0612@1|root,COG0612@2|Bacteria,3Y77X@57723|Acidobacteria 57723|Acidobacteria S Insulinase (Peptidase family M16) - - - - - - - - - - - - Peptidase_M16,Peptidase_M16_C k59_559549_1 1122135.KB893169_gene2561 1.9e-81 271.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2TQT0@28211|Alphaproteobacteria 28211|Alphaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family ttgE - - ko:K18989 - M00720 - - ko00000,ko00002,ko02000 2.A.6.2.30 - - ACR_tran k59_1126489_1 235279.HH_1099 2.86e-33 127.0 COG1044@1|root,COG1044@2|Bacteria,1MUX6@1224|Proteobacteria,42M4X@68525|delta/epsilon subdivisions,2YMCF@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell lpxD - 2.3.1.191 ko:K02536 ko00540,ko01100,map00540,map01100 M00060 R04550 RC00039,RC00166 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Hexapep,Hexapep_2,LpxD k59_674513_1 1229909.NSED_09505 3.65e-124 361.0 COG0462@1|root,arCOG00067@2157|Archaea,41SH1@651137|Thaumarchaeota 651137|Thaumarchaeota F Ribose-phosphate pyrophosphokinase - - 2.7.6.1 ko:K00948 ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230 M00005 R01049 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - Pribosyl_synth,Pribosyltran,Pribosyltran_N k59_503622_1 485913.Krac_3644 2.46e-53 177.0 COG0179@1|root,COG0179@2|Bacteria,2G7MW@200795|Chloroflexi 200795|Chloroflexi Q PFAM fumarylacetoacetate (FAA) hydrolase - - 3.7.1.2 ko:K16171 ko00350,ko00643,ko01100,ko01120,map00350,map00643,map01100,map01120 M00044 R01364 RC00326,RC00446 ko00000,ko00001,ko00002,ko01000 - - - FAA_hydrolase k59_559571_2 580332.Slit_1793 1.94e-68 227.0 COG1138@1|root,COG1138@2|Bacteria,1MUQS@1224|Proteobacteria,2VHUE@28216|Betaproteobacteria,44VEM@713636|Nitrosomonadales 28216|Betaproteobacteria O TIGRFAM cytochrome c-type biogenesis protein CcmF ccmF - - ko:K02198 - - - - ko00000,ko02000 9.B.14.1 - - CcmF_C,Cytochrom_C_asm k59_845811_1 288000.BBta_2912 4.59e-37 140.0 COG0183@1|root,COG0183@2|Bacteria,1QUU1@1224|Proteobacteria,2U0EW@28211|Alphaproteobacteria,3JR6T@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria I Belongs to the thiolase family MA20_16420 - 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - - - k59_1637097_1 436308.Nmar_0380 6.04e-75 235.0 arCOG10517@1|root,arCOG10517@2157|Archaea,41T0I@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1351732_1 1173264.KI913949_gene1576 2.63e-23 93.6 COG3415@1|root,COG3415@2|Bacteria,1G802@1117|Cyanobacteria 1117|Cyanobacteria L Homeodomain-like domain - - - - - - - - - - - - HTH_23,HTH_32 k59_1351732_2 485913.Krac_2355 2.64e-68 219.0 COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,2G9RC@200795|Chloroflexi 200795|Chloroflexi L DDE superfamily endonuclease - - - - - - - - - - - - DDE_3,HTH_32 k59_1295778_1 1282362.AEAC466_18070 1.61e-32 125.0 COG0665@1|root,COG0665@2|Bacteria,1QWUN@1224|Proteobacteria,2U2AA@28211|Alphaproteobacteria 28211|Alphaproteobacteria E FAD dependent oxidoreductase - - - - - - - - - - - - FAD_oxidored k59_1295778_2 1394178.AWOO02000023_gene5574 5.71e-06 49.3 COG4977@1|root,COG4977@2|Bacteria,2GIRA@201174|Actinobacteria,4EFQ9@85012|Streptosporangiales 201174|Actinobacteria K helix_turn_helix, arabinose operon control protein - - - - - - - - - - - - DJ-1_PfpI,HTH_18 k59_1692471_1 1353529.M899_1740 6.87e-80 258.0 COG1384@1|root,COG1384@2|Bacteria,1MV32@1224|Proteobacteria,42YMX@68525|delta/epsilon subdivisions,2WTJU@28221|Deltaproteobacteria 28221|Deltaproteobacteria J tRNA synthetases class I (K) lysS - 6.1.1.6 ko:K04566 ko00970,map00970 M00360 R03658 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_1f k59_1465358_1 1122137.AQXF01000003_gene2462 1.19e-234 646.0 COG0059@1|root,COG0059@2|Bacteria,1MV7M@1224|Proteobacteria,2TRXI@28211|Alphaproteobacteria 28211|Alphaproteobacteria EH Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate ilvC - 1.1.1.86 ko:K00053 ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R03051,R04439,R04440,R05068,R05069,R05071 RC00726,RC00836,RC00837,RC01726 ko00000,ko00001,ko00002,ko01000 - - - IlvC,IlvN k59_448441_1 357808.RoseRS_1798 7.5e-22 96.7 COG0725@1|root,COG0725@2|Bacteria,2G6J6@200795|Chloroflexi,376NT@32061|Chloroflexia 32061|Chloroflexia P TIGRFAM molybdenum ABC transporter, periplasmic molybdate-binding protein - - - ko:K02020 ko02010,map02010 M00189 - - ko00000,ko00001,ko00002,ko02000 3.A.1.8 - - SBP_bac_11 k59_674556_1 504487.JCM19302_3475 4.17e-20 88.2 COG2115@1|root,COG2115@2|Bacteria,4NEBQ@976|Bacteroidetes,1HXW8@117743|Flavobacteriia 976|Bacteroidetes G Catalyzes the interconversion of D-xylose to D-xylulose xylA - 5.3.1.5 ko:K01805 ko00040,ko00051,ko01100,map00040,map00051,map01100 - R00878,R01432 RC00376,RC00516 ko00000,ko00001,ko01000 - - - - k59_674556_2 1392498.JQLH01000001_gene2692 3.29e-38 141.0 COG1070@1|root,COG1070@2|Bacteria,4NFBZ@976|Bacteroidetes,1HXH0@117743|Flavobacteriia,2PGPK@252356|Maribacter 976|Bacteroidetes G FGGY family of carbohydrate kinases, C-terminal domain - - 2.7.1.17 ko:K00854 ko00040,ko01100,map00040,map01100 M00014 R01639 RC00002,RC00538 ko00000,ko00001,ko00002,ko01000 - - - FGGY_C,FGGY_N k59_786107_1 377629.TERTU_4087 3.73e-16 84.3 COG1629@1|root,COG1629@2|Bacteria,COG4771@2|Bacteria,1MWKN@1224|Proteobacteria,1RNWV@1236|Gammaproteobacteria,2PNBK@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria P TonB dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_1185045_1 1132855.KB913035_gene775 1.06e-101 302.0 COG4535@1|root,COG4535@2|Bacteria,1QTU8@1224|Proteobacteria,2VIU8@28216|Betaproteobacteria,2KM7R@206350|Nitrosomonadales 206350|Nitrosomonadales P PFAM CBS domain - - - ko:K06189 - - - - ko00000,ko02000 9.A.40.1.2 - - CBS,CorC_HlyC k59_845820_1 1219375.CM002139_gene20 6.87e-22 99.0 COG3519@1|root,COG3519@2|Bacteria,1MUY4@1224|Proteobacteria,1RPK4@1236|Gammaproteobacteria,1X4C2@135614|Xanthomonadales 135614|Xanthomonadales S type VI secretion protein - - - ko:K11896 - M00334 - - ko00000,ko00002,ko02044 3.A.23.1 - - T6SS_TssF k59_1185046_1 1096930.L284_02975 1.38e-49 159.0 29ENN@1|root,301KJ@2|Bacteria,1N4M2@1224|Proteobacteria,2UD17@28211|Alphaproteobacteria,2K6YR@204457|Sphingomonadales 204457|Sphingomonadales - - - - - - - - - - - - - - - k59_1185046_2 1479239.JQMU01000001_gene1295 6.04e-18 78.6 COG3740@1|root,COG3740@2|Bacteria,1N2D8@1224|Proteobacteria,2UD3U@28211|Alphaproteobacteria,2K6IB@204457|Sphingomonadales 204457|Sphingomonadales S Phage head maturation protease - - - ko:K06904 - - - - ko00000 - - - Peptidase_S78 k59_167681_1 1117319.PSPO_01645 3.36e-05 51.2 COG5184@1|root,COG5492@1|root,COG5184@2|Bacteria,COG5492@2|Bacteria,1R8Z4@1224|Proteobacteria,1S0IR@1236|Gammaproteobacteria,2Q1E7@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria N Protein of unknown function (DUF1566) - - - - - - - - - - - - DUF1566,REJ k59_167683_1 365046.Rta_19360 6.07e-71 224.0 COG0723@1|root,COG0723@2|Bacteria,1MZ7A@1224|Proteobacteria,2VVI5@28216|Betaproteobacteria 28216|Betaproteobacteria C plastoquinol--plastocyanin reductase activity - - - - - - - - - - - - - k59_167684_1 247633.GP2143_00962 4.5e-60 194.0 COG0500@1|root,COG2226@2|Bacteria,1MV4M@1224|Proteobacteria,1RMWY@1236|Gammaproteobacteria,1J535@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria Q Catalyzes the conversion of S-adenosyl-L-methionine (SAM) to carboxy-S-adenosyl-L-methionine (Cx-SAM) cmoA GO:0002097,GO:0002098,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360 - ko:K15256 - - - - ko00000,ko01000,ko03016 - - - Methyltransf_25 k59_1637102_1 870187.Thini_0519 3.95e-113 343.0 COG1721@1|root,COG1721@2|Bacteria,1MXDI@1224|Proteobacteria,1RQSS@1236|Gammaproteobacteria 1236|Gammaproteobacteria S conserved protein (some members contain a von Willebrand factor type A (vWA) domain) - - - - - - - - - - - - DUF58 k59_1185051_1 697282.Mettu_3983 2.17e-31 127.0 COG4773@1|root,COG4773@2|Bacteria,1QVK7@1224|Proteobacteria,1T53A@1236|Gammaproteobacteria,1XDUB@135618|Methylococcales 135618|Methylococcales P TonB-dependent Receptor Plug - - - - - - - - - - - - Plug,TonB_dep_Rec k59_674582_1 1005048.CFU_3959 1.99e-33 120.0 COG1490@1|root,COG1490@2|Bacteria,1RGTV@1224|Proteobacteria,2VR31@28216|Betaproteobacteria,474FN@75682|Oxalobacteraceae 28216|Betaproteobacteria J rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality dtd - - ko:K07560 - - - - ko00000,ko01000,ko03016 - - - Tyr_Deacylase k59_674582_2 1095769.CAHF01000022_gene248 4.15e-31 120.0 COG3173@1|root,COG3173@2|Bacteria,1MWAK@1224|Proteobacteria,2VJ31@28216|Betaproteobacteria,474PP@75682|Oxalobacteraceae 28216|Betaproteobacteria S Phosphotransferase enzyme family - - - - - - - - - - - - APH k59_1295818_1 1229909.NSED_00085 5.69e-20 84.3 COG2109@1|root,arCOG04678@2157|Archaea,41SFP@651137|Thaumarchaeota 651137|Thaumarchaeota H ATP corrinoid adenosyltransferase - - 2.5.1.17 ko:K19221 ko00860,ko01100,map00860,map01100 M00122 R01492,R05220,R07268 RC00533 ko00000,ko00001,ko00002,ko01000 - - - CobA_CobO_BtuR k59_1692523_1 981369.JQMJ01000003_gene7822 2.48e-57 200.0 COG0550@1|root,COG1754@1|root,COG0550@2|Bacteria,COG1754@2|Bacteria,2GJU7@201174|Actinobacteria,2NH60@228398|Streptacidiphilus 201174|Actinobacteria L Bacterial DNA topoisomeraes I ATP-binding domain topA GO:0000287,GO:0003674,GO:0003824,GO:0003916,GO:0003917,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0009892,GO:0010605,GO:0016020,GO:0016853,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031324,GO:0032069,GO:0032074,GO:0040007,GO:0043086,GO:0043167,GO:0043169,GO:0044092,GO:0044424,GO:0044444,GO:0044464,GO:0045934,GO:0046872,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051336,GO:0051346,GO:0060255,GO:0060700,GO:0060701,GO:0065007,GO:0065009,GO:0071944,GO:0080090,GO:0140097 5.99.1.2 ko:K03168 - - - - ko00000,ko01000,ko03032,ko03400 - - - Topoisom_bac,Toprim,Toprim_C_rpt k59_786139_1 679197.HMPREF9336_03421 6.98e-16 79.0 COG1678@1|root,COG1678@2|Bacteria,2GNRA@201174|Actinobacteria 201174|Actinobacteria K Belongs to the UPF0301 (AlgH) family - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K07735 - - - - ko00000,ko03000 - - - DUF179 k59_956717_1 448385.sce8096 3.85e-27 112.0 COG0845@1|root,COG0845@2|Bacteria,1MVAS@1224|Proteobacteria,42PKU@68525|delta/epsilon subdivisions,2WM5K@28221|Deltaproteobacteria,2YZUC@29|Myxococcales 28221|Deltaproteobacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - ko:K07798 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.6.1.4,8.A.1 - - DUF3347,HlyD_D23 k59_1465412_2 1535422.ND16A_2983 6.19e-10 63.5 COG3193@1|root,COG3193@2|Bacteria,1R3RC@1224|Proteobacteria,1S0DK@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Haem-degrading - - - - - - - - - - - - Haem_degrading k59_167726_1 1120953.AUBH01000002_gene1453 5.86e-95 313.0 COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1145@1|root,COG1146@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1145@2|Bacteria,COG1146@2|Bacteria,1MVM0@1224|Proteobacteria,1RNNX@1236|Gammaproteobacteria,464U2@72275|Alteromonadaceae 1236|Gammaproteobacteria C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin - - 1.2.7.1 ko:K03737 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00173,M00307 R01196,R10866 RC00004,RC02742 br01601,ko00000,ko00001,ko00002,ko01000 - - - EKR,Fer4,Fer4_13,Fer4_16,Fer4_6,PFOR_II,POR,POR_N,TPP_enzyme_C k59_1241163_1 1144305.PMI02_00428 3.46e-176 519.0 COG1629@1|root,COG1629@2|Bacteria,COG4771@2|Bacteria,1MV8W@1224|Proteobacteria,2TSUV@28211|Alphaproteobacteria,2JZV0@204457|Sphingomonadales 204457|Sphingomonadales P receptor - - - - - - - - - - - - Plug,TonB_dep_Rec k59_845911_1 926550.CLDAP_01010 1.45e-59 211.0 COG0784@1|root,COG2202@1|root,COG3290@1|root,COG3614@1|root,COG5002@1|root,COG0784@2|Bacteria,COG2202@2|Bacteria,COG3290@2|Bacteria,COG3614@2|Bacteria,COG5002@2|Bacteria 2|Bacteria T protein histidine kinase activity - - - - - - - - - - - - CHASE,GAF,GAF_2,HATPase_c,HisKA,Hpt,PAS,PAS_3,PAS_4,PAS_9,Response_reg k59_1692578_1 596151.DesfrDRAFT_3539 3.48e-82 268.0 COG0296@1|root,COG0296@2|Bacteria,1MVM7@1224|Proteobacteria,42MKI@68525|delta/epsilon subdivisions,2WIQJ@28221|Deltaproteobacteria,2M9MH@213115|Desulfovibrionales 28221|Deltaproteobacteria G Glycoside hydrolase, family 13 treZ - 3.2.1.141 ko:K01236 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R09995,R11256 RC00049 ko00000,ko00001,ko00002,ko01000 - CBM48,GH13 - Alpha-amylase,CBM_48,DUF3459 k59_786193_2 1552758.NC00_20050 5.63e-64 211.0 COG3507@1|root,COG3507@2|Bacteria,1MWY2@1224|Proteobacteria,1RR93@1236|Gammaproteobacteria,1X2XR@135614|Xanthomonadales 135614|Xanthomonadales G Belongs to the glycosyl hydrolase 43 family - - 3.2.1.37 ko:K01198 ko00520,ko01100,map00520,map01100 - R01433 RC00467 ko00000,ko00001,ko01000 - GH43 - Glyco_hydro_43 k59_117828_1 314275.MADE_1004035 5.73e-20 85.1 COG0736@1|root,COG0736@2|Bacteria,1MZBF@1224|Proteobacteria,1S98P@1236|Gammaproteobacteria,467XX@72275|Alteromonadaceae 1236|Gammaproteobacteria I Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein acpS GO:0003674,GO:0003824,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0008897,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016772,GO:0016780,GO:0018070,GO:0018193,GO:0018209,GO:0018215,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:0072330,GO:1901564,GO:1901576 2.7.8.7 ko:K00997 ko00770,map00770 - R01625 RC00002 ko00000,ko00001,ko01000 - - - ACPS k59_117828_2 1121937.AUHJ01000001_gene590 5.28e-09 58.5 COG1381@1|root,COG1381@2|Bacteria,1RHIC@1224|Proteobacteria,1RN8Y@1236|Gammaproteobacteria,46776@72275|Alteromonadaceae 1236|Gammaproteobacteria L Involved in DNA repair and RecF pathway recombination recO GO:0008150,GO:0009314,GO:0009628,GO:0050896 - ko:K03584 ko03440,map03440 - - - ko00000,ko00001,ko03400 - - - RecO_C,RecO_N k59_1191139_1 395493.BegalDRAFT_3018 7.49e-33 129.0 COG1640@1|root,COG1640@2|Bacteria,1QTVJ@1224|Proteobacteria,1RMJW@1236|Gammaproteobacteria,45ZQG@72273|Thiotrichales 72273|Thiotrichales G 4-alpha-glucanotransferase - - 2.4.1.25 ko:K00705 ko00500,ko01100,map00500,map01100 - R05196 RC00049 ko00000,ko00001,ko01000 - GH77 - Glyco_hydro_77 k59_739469_1 1449976.KALB_2089 2e-35 134.0 COG1228@1|root,COG1228@2|Bacteria,2GMUS@201174|Actinobacteria,4E1ST@85010|Pseudonocardiales 201174|Actinobacteria Q Amidohydrolase family - - - - - - - - - - - - Amidohydro_1 k59_1021992_1 1288083.AUKR01000021_gene1538 5.89e-57 198.0 COG2217@1|root,COG2217@2|Bacteria,2GIRF@201174|Actinobacteria 201174|Actinobacteria P Heavy metal translocating P-type atpase - - 3.6.3.54 ko:K17686 ko01524,ko04016,map01524,map04016 - R00086 RC00002 ko00000,ko00001,ko01000 3.A.3.5 - - E1-E2_ATPase,HMA,Hydrolase k59_1021992_2 318424.EU78_15130 3.35e-58 184.0 COG0394@1|root,COG0394@2|Bacteria,2IHR3@201174|Actinobacteria,2352Q@1762|Mycobacteriaceae 201174|Actinobacteria T Low molecular weight phosphotyrosine protein phosphatase - - 1.20.4.1 ko:K03741 - - - - ko00000,ko01000 - - - LMWPc k59_1021992_3 1386089.N865_15500 2.2e-05 45.1 2EJAX@1|root,33D21@2|Bacteria,2HUZD@201174|Actinobacteria,4FJN3@85021|Intrasporangiaceae 201174|Actinobacteria S MT0933-like antitoxin protein - - - - - - - - - - - - MT0933_antitox k59_1755887_1 1353529.M899_1347 1.15e-23 107.0 COG0642@1|root,COG4251@1|root,COG5002@1|root,COG0642@2|Bacteria,COG2205@2|Bacteria,COG4251@2|Bacteria,COG5002@2|Bacteria,1NRP8@1224|Proteobacteria,42M0Y@68525|delta/epsilon subdivisions,2MTI7@213481|Bdellovibrionales,2WIR4@28221|Deltaproteobacteria 213481|Bdellovibrionales T Histidine kinase A domain protein - - - - - - - - - - - - CHASE,HATPase_c,HisKA,PAS_3,Response_reg k59_852156_1 1122225.AULQ01000002_gene811 5.01e-08 52.8 COG0299@1|root,COG0299@2|Bacteria,4NNZP@976|Bacteroidetes,1I19R@117743|Flavobacteriia 976|Bacteroidetes F Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate purN - 2.1.2.2 ko:K11175 ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130 M00048 R04325,R04326 RC00026,RC00197,RC01128 ko00000,ko00001,ko00002,ko01000 - - - Formyl_trans_N k59_852156_2 504487.JCM19302_2670 7.35e-65 202.0 COG0328@1|root,COG3341@1|root,COG0328@2|Bacteria,COG3341@2|Bacteria,4NI01@976|Bacteroidetes,1HXD6@117743|Flavobacteriia 976|Bacteroidetes L double-stranded RNA RNA-DNA hybrid binding protein rnhA - 3.1.26.4 ko:K03469 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - Cauli_VI,RNase_H k59_1586251_1 1151122.AQYD01000007_gene555 1.18e-45 164.0 COG0665@1|root,COG0665@2|Bacteria,2GJQ9@201174|Actinobacteria,4FK98@85023|Microbacteriaceae 201174|Actinobacteria E Thi4 family - - - - - - - - - - - - DAO k59_230535_1 493475.GARC_1912 2.78e-13 73.2 COG2304@1|root,COG2304@2|Bacteria,1MXQ7@1224|Proteobacteria,1RMDX@1236|Gammaproteobacteria,464NT@72275|Alteromonadaceae 1236|Gammaproteobacteria S protein containing a von Willebrand factor type A (vWA) domain batA - - ko:K07114 - - - - ko00000,ko02000 1.A.13.2.2,1.A.13.2.3 - - VWA k59_512967_2 1122185.N792_08060 2.09e-57 189.0 COG3279@1|root,COG3279@2|Bacteria,1NWIR@1224|Proteobacteria,1SPGG@1236|Gammaproteobacteria,1X9XJ@135614|Xanthomonadales 135614|Xanthomonadales T LytTr DNA-binding domain - - - - - - - - - - - - LytTR,Response_reg k59_512967_3 1278073.MYSTI_02735 2.98e-33 131.0 COG2972@1|root,COG2972@2|Bacteria,1QU20@1224|Proteobacteria 1224|Proteobacteria T Histidine kinase - - - - - - - - - - - - 7TMR-DISM_7TM,His_kinase k59_1643086_2 394221.Mmar10_1604 8.72e-38 138.0 COG1228@1|root,COG1228@2|Bacteria,1MUYR@1224|Proteobacteria,2TSA1@28211|Alphaproteobacteria,43WYK@69657|Hyphomonadaceae 28211|Alphaproteobacteria Q COG1228 Imidazolonepropionase and related amidohydrolases hutI - 3.5.2.7 ko:K01468 ko00340,ko01100,map00340,map01100 M00045 R02288 RC00683 ko00000,ko00001,ko00002,ko01000 - - - Amidohydro_1,Amidohydro_3 k59_1077985_1 391038.Bphy_4752 6.9e-121 363.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2VHSB@28216|Betaproteobacteria,1K375@119060|Burkholderiaceae 28216|Betaproteobacteria T response regulator zraR - - - - - - - - - - - HTH_8,Response_reg,Sigma54_activat k59_1643087_1 1197706.AKKK01000009_gene524 2.39e-20 93.2 COG1028@1|root,COG1028@2|Bacteria,2H8Y7@201174|Actinobacteria 201174|Actinobacteria IQ Short-chain dehydrogenase reductase sdr - - - - - - - - - - - - adh_short_C2 k59_4694_1 502025.Hoch_3565 1.37e-142 441.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,43EBY@68525|delta/epsilon subdivisions,2X7W0@28221|Deltaproteobacteria,2Z3IQ@29|Myxococcales 28221|Deltaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K07787 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.6.1.4 - - ACR_tran k59_1077993_2 436308.Nmar_0664 4.88e-22 97.1 COG1887@1|root,arCOG04827@2157|Archaea 2157|Archaea M CDP-glycerol poly(glycerophosphate) glycerophosphotransferase - - - - - - - - - - - - Glyphos_transf k59_343931_1 1115803.HMPREF1129_0233 1.99e-29 124.0 COG1123@1|root,COG4172@2|Bacteria,2H3HY@201174|Actinobacteria,4D82B@85005|Actinomycetales 201174|Actinobacteria P Oligopeptide/dipeptide transporter, C-terminal region - - - ko:K02031,ko:K02032 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - ABC_tran,BPD_transp_1,oligo_HPY k59_400183_1 622637.KE124774_gene3671 3.1e-98 295.0 COG3547@1|root,COG3547@2|Bacteria,1Q4TE@1224|Proteobacteria,2TT7C@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Transposase - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_4708_1 211586.SO_0365 2.32e-19 94.4 COG2807@1|root,COG2807@2|Bacteria,1NXQ2@1224|Proteobacteria,1RXXM@1236|Gammaproteobacteria,2QABM@267890|Shewanellaceae 1236|Gammaproteobacteria P MFS_1 like family - - - - - - - - - - - - MFS_1 k59_1529962_1 158500.BV97_00720 5.1e-91 275.0 COG1077@1|root,COG1077@2|Bacteria,1MUMW@1224|Proteobacteria,2TTQ2@28211|Alphaproteobacteria,2K10A@204457|Sphingomonadales 204457|Sphingomonadales D rod shape-determining protein MreB mreB - - ko:K03569 - - - - ko00000,ko02048,ko03036,ko04812 1.A.33.1,9.B.157.1 - - MreB_Mbl k59_117862_1 1229909.NSED_09645 5.68e-111 331.0 COG1311@1|root,arCOG04455@2157|Archaea,41T0D@651137|Thaumarchaeota 651137|Thaumarchaeota L Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase polB - 2.7.7.7 ko:K02323 ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030 M00264 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032 - - - DNA_pol_E_B k59_1191200_1 1454004.AW11_03085 2.25e-81 263.0 28HMZ@1|root,2Z7WD@2|Bacteria,1MU3Q@1224|Proteobacteria 1224|Proteobacteria S Protein of unknown function (DUF3604) - - - - - - - - - - - - DUF3604 k59_1078003_1 266265.Bxe_C0542 1.56e-115 337.0 COG0664@1|root,COG0664@2|Bacteria,1NEQM@1224|Proteobacteria,2VH1V@28216|Betaproteobacteria,1K3TN@119060|Burkholderiaceae 28216|Betaproteobacteria K CRP FNR family - - - - - - - - - - - - HTH_Crp_2,cNMP_binding k59_1078003_2 517417.Cpar_1700 1.81e-51 175.0 COG3004@1|root,COG3004@2|Bacteria,1FDWE@1090|Chlorobi 1090|Chlorobi P ) H( ) antiporter that extrudes sodium in exchange for external protons nhaA - - ko:K03313 - - - - ko00000,ko02000 2.A.33.1 - - Na_H_antiport_1 k59_1304121_1 1537994.JQFW01000027_gene2058 0.000184 46.6 COG2273@1|root,COG2273@2|Bacteria,1NFHX@1224|Proteobacteria,1RRPK@1236|Gammaproteobacteria,464WR@72275|Alteromonadaceae 1236|Gammaproteobacteria G Glycosyl hydrolases family 16 - - - - - - - - - - - - CBM_6,Glyco_hydro_16 k59_1191207_1 1380763.BG53_12150 2.08e-19 91.7 COG0770@1|root,COG0770@2|Bacteria,1VT78@1239|Firmicutes,4HACR@91061|Bacilli,26S7E@186822|Paenibacillaceae 91061|Bacilli M Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein murF - 6.3.2.10 ko:K01929 ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502 - R04573,R04617 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_400214_1 158500.BV97_05617 2.79e-40 133.0 2AKTT@1|root,31BKU@2|Bacteria,1P11P@1224|Proteobacteria,2UU22@28211|Alphaproteobacteria,2K71J@204457|Sphingomonadales 204457|Sphingomonadales - - - - - - - - - - - - - - - k59_400214_2 1101188.KI912157_gene25 3.25e-12 68.6 COG0673@1|root,COG0673@2|Bacteria,2GN2Z@201174|Actinobacteria,1W9X8@1268|Micrococcaceae 201174|Actinobacteria S Oxidoreductase - - - - - - - - - - - - GFO_IDH_MocA,GFO_IDH_MocA_C k59_117872_1 1132855.KB913035_gene1392 6.5e-14 73.6 COG3149@1|root,COG3149@2|Bacteria,1R36I@1224|Proteobacteria,2WIFT@28216|Betaproteobacteria,2KPBR@206350|Nitrosomonadales 206350|Nitrosomonadales U Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins - - - - - - - - - - - - - k59_1473604_1 1121924.ATWH01000010_gene860 1.01e-10 63.2 COG0578@1|root,COG0578@2|Bacteria,2GJKN@201174|Actinobacteria,4FKEP@85023|Microbacteriaceae 201174|Actinobacteria C C-terminal domain of alpha-glycerophosphate oxidase glpD - 1.1.5.3 ko:K00111 ko00564,ko01110,map00564,map01110 - R00848 RC00029 ko00000,ko00001,ko01000 - - - DAO,DAO_C k59_1473604_2 1313172.YM304_24680 6.92e-24 101.0 COG2230@1|root,COG2230@2|Bacteria,2H060@201174|Actinobacteria 201174|Actinobacteria M Methyltransferase - - - - - - - - - - - - Methyltransf_31 k59_739533_1 1386089.N865_01685 3.03e-14 83.2 COG0658@1|root,COG2333@1|root,COG0658@2|Bacteria,COG2333@2|Bacteria,2GJGR@201174|Actinobacteria,4FEQ6@85021|Intrasporangiaceae 201174|Actinobacteria S membrane comEC - - ko:K02238 - M00429 - - ko00000,ko00002,ko02044 3.A.11.1,3.A.11.2 - - Competence,DUF4131,Lactamase_B k59_739533_2 1284679.HMPREF1626_00760 9.08e-12 63.9 COG1555@1|root,COG1555@2|Bacteria,2IQDC@201174|Actinobacteria,4D3V2@85005|Actinomycetales 201174|Actinobacteria L ComEA protein comEA - - ko:K02237 - M00429 - - ko00000,ko00002,ko02044 3.A.11.1,3.A.11.2 - - HHH_3,SLBB k59_1247633_1 504487.JCM19302_149 2.96e-67 225.0 COG0755@1|root,COG1333@1|root,COG0755@2|Bacteria,COG1333@2|Bacteria,4NDY1@976|Bacteroidetes,1HXDN@117743|Flavobacteriia 976|Bacteroidetes O cytochrome c biogenesis ccsA - - - - - - - - - - - Cytochrom_C_asm,ResB k59_400225_1 1123270.ATUR01000002_gene2592 4.11e-79 249.0 COG0624@1|root,COG0624@2|Bacteria,1MWJS@1224|Proteobacteria,2TUHT@28211|Alphaproteobacteria,2K1MW@204457|Sphingomonadales 204457|Sphingomonadales E Acetylornithine deacetylase Succinyl-diaminopimelate - - - - - - - - - - - - M20_dimer,Peptidase_M20,Peptidase_M28 k59_1699468_1 290397.Adeh_3845 2.15e-53 183.0 COG0312@1|root,COG0312@2|Bacteria,1RBJZ@1224|Proteobacteria,42YBE@68525|delta/epsilon subdivisions,2WUP7@28221|Deltaproteobacteria,2YZ4Y@29|Myxococcales 28221|Deltaproteobacteria L Putative modulator of DNA gyrase - - - ko:K03592 - - - - ko00000,ko01002 - - - PmbA_TldD k59_1755912_1 2340.JV46_03520 3.24e-106 317.0 COG0126@1|root,COG0126@2|Bacteria,1MUNU@1224|Proteobacteria,1RMUQ@1236|Gammaproteobacteria,1J4P4@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria F Belongs to the phosphoglycerate kinase family pgk GO:0003674,GO:0003824,GO:0004618,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016052,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576 2.7.2.3 ko:K00927 ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01512 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000,ko04147 - - iSbBS512_1146.SbBS512_E3351 PGK k59_795779_1 1163617.SCD_n00412 1.03e-54 185.0 COG1565@1|root,COG1565@2|Bacteria,1N3CJ@1224|Proteobacteria,2VHBE@28216|Betaproteobacteria 28216|Betaproteobacteria S Putative S-adenosyl-L-methionine-dependent methyltransferase - - - - - - - - - - - - Methyltransf_28 k59_4729_1 436308.Nmar_0657 3.18e-168 480.0 COG1262@1|root,arCOG03517@2157|Archaea,41T1B@651137|Thaumarchaeota 651137|Thaumarchaeota S DinB superfamily - - - - - - - - - - - - DinB_2,FGE-sulfatase k59_965049_2 543728.Vapar_4064 1.07e-22 95.9 COG3381@1|root,COG3381@2|Bacteria,1MWWM@1224|Proteobacteria,2VJ39@28216|Betaproteobacteria,4ACXM@80864|Comamonadaceae 28216|Betaproteobacteria S cytoplasmic chaperone TorD family protein torD - - - - - - - - - - - Nitrate_red_del k59_1304136_1 1082933.MEA186_35179 6.61e-28 108.0 COG2518@1|root,COG2518@2|Bacteria,1MXQC@1224|Proteobacteria,2TVCY@28211|Alphaproteobacteria,43KM8@69277|Phyllobacteriaceae 28211|Alphaproteobacteria O Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins pcm - 2.1.1.77 ko:K00573 - - - - ko00000,ko01000 - - - Erythro_esteras,PCMT k59_1304136_2 1163617.SCD_n02203 8.89e-27 104.0 COG1515@1|root,COG1515@2|Bacteria,1MWRN@1224|Proteobacteria,2VQJE@28216|Betaproteobacteria 28216|Betaproteobacteria L DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA nfi - 3.1.21.7 ko:K05982 - - - - ko00000,ko01000,ko03400 - - - Endonuclease_5 k59_1586311_1 316407.85674876 2.31e-151 451.0 COG3468@1|root,COG3468@2|Bacteria,1R3VW@1224|Proteobacteria,1RSKC@1236|Gammaproteobacteria 1236|Gammaproteobacteria MU cell adhesion involved in biofilm formation ycgV GO:0007155,GO:0008150,GO:0009987,GO:0022610,GO:0031589,GO:0042710,GO:0043708,GO:0044764,GO:0051704,GO:0090605 - - - - - - - - - - Autotransporter,Pertactin k59_1643167_1 383372.Rcas_3465 1.08e-99 304.0 COG3385@1|root,COG3385@2|Bacteria,2G80K@200795|Chloroflexi 200795|Chloroflexi L sptr a7nhu5 - - - - - - - - - - - - DDE_5 k59_117892_1 1397278.AYMV01000028_gene2571 1.95e-108 323.0 COG0189@1|root,COG0189@2|Bacteria,2HXBM@201174|Actinobacteria,4FK87@85023|Microbacteriaceae 201174|Actinobacteria HJ RimK-like ATP-grasp domain rimK - 6.3.2.43 ko:K05827,ko:K05844 ko00300,ko01100,ko01210,ko01230,map00300,map01100,map01210,map01230 M00031 R09775 RC00064,RC00090 ko00000,ko00001,ko00002,ko01000,ko03009 - - - RimK,TrkA_C k59_343986_2 502025.Hoch_4973 3.28e-54 185.0 COG0415@1|root,COG0415@2|Bacteria,1RG4D@1224|Proteobacteria,42NWP@68525|delta/epsilon subdivisions,2WJUA@28221|Deltaproteobacteria,2YUE6@29|Myxococcales 28221|Deltaproteobacteria L Deoxyribodipyrimidine photo-lyase phr - 4.1.99.3 ko:K01669 - - - - ko00000,ko01000,ko03400 - - - DNA_photolyase,FAD_binding_7 k59_1360591_1 926550.CLDAP_04830 6.59e-50 175.0 COG0473@1|root,COG0473@2|Bacteria,2G66J@200795|Chloroflexi 200795|Chloroflexi C PFAM isocitrate isopropylmalate dehydrogenase - - 1.1.1.87 ko:K05824 ko00300,ko01100,ko01120,ko01130,ko01210,ko01230,map00300,map01100,map01120,map01130,map01210,map01230 M00030,M00433 R01934,R01936,R04862 RC00084,RC00114,RC00626 br01601,ko00000,ko00001,ko00002,ko01000 - - - Iso_dh k59_4743_1 1229909.NSED_09545 1.4e-99 302.0 COG1746@1|root,arCOG04249@2157|Archaea,41S76@651137|Thaumarchaeota 651137|Thaumarchaeota J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate cca - 2.7.7.72 ko:K07558 - - R09382,R09383,R09384,R09386 RC00078 ko00000,ko01000,ko03016 - - - NTP_transf_2,tRNA_NucTransf2 k59_513016_1 1232683.ADIMK_4077 8.28e-61 199.0 COG0683@1|root,COG0683@2|Bacteria,1MWGW@1224|Proteobacteria,1RQ5G@1236|Gammaproteobacteria,465XF@72275|Alteromonadaceae 1236|Gammaproteobacteria E TIGRFAM ABC transporter, substrate binding protein, PQQ-dependent alcohol dehydrogenase system - - - - - - - - - - - - Peripla_BP_6 k59_1416890_2 979556.MTES_2824 1.5e-13 71.6 COG0334@1|root,COG0334@2|Bacteria,2IHIC@201174|Actinobacteria,4FMX2@85023|Microbacteriaceae 201174|Actinobacteria E Glutamate/Leucine/Phenylalanine/Valine dehydrogenase - - 1.4.1.9 ko:K00263 ko00280,ko00290,ko01100,ko01110,ko01130,map00280,map00290,map01100,map01110,map01130 - R01088,R01434,R02196 RC00006,RC00036 ko00000,ko00001,ko01000 - - - ELFV_dehydrog,ELFV_dehydrog_N k59_1022079_2 1111729.ATYV01000017_gene1873 3.62e-08 59.7 COG3333@1|root,COG3333@2|Bacteria,2GJB2@201174|Actinobacteria,22M70@1653|Corynebacteriaceae 201174|Actinobacteria S protein conserved in bacteria - - - ko:K07793 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.80.1 - - TctA k59_1530050_1 765911.Thivi_0995 9.29e-64 204.0 COG0059@1|root,COG0059@2|Bacteria,1MV7M@1224|Proteobacteria,1RNA8@1236|Gammaproteobacteria,1WWXU@135613|Chromatiales 135613|Chromatiales EH Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate ilvC - 1.1.1.86 ko:K00053 ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R03051,R04439,R04440,R05068,R05069,R05071 RC00726,RC00836,RC00837,RC01726 ko00000,ko00001,ko00002,ko01000 - - - IlvC,IlvN k59_1530050_2 316067.Geob_1506 5.38e-13 70.1 COG0688@1|root,COG0688@2|Bacteria,1MW45@1224|Proteobacteria,42SYM@68525|delta/epsilon subdivisions,2WP8C@28221|Deltaproteobacteria,43UT8@69541|Desulfuromonadales 28221|Deltaproteobacteria I Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer) psd - 4.1.1.65 ko:K01613 ko00564,ko01100,ko01110,map00564,map01100,map01110 M00093 R02055 RC00299 ko00000,ko00001,ko00002,ko01000 - - - PS_Dcarbxylase k59_400251_1 1347342.BN863_6870 3.31e-67 213.0 COG0530@1|root,COG0530@2|Bacteria,4NFBC@976|Bacteroidetes,1HXR1@117743|Flavobacteriia 976|Bacteroidetes P Ca2 Na antiporter yrbG - - ko:K07301 - - - - ko00000,ko02000 2.A.19.5 - - Na_Ca_ex k59_626043_1 391615.ABSJ01000045_gene2008 3.71e-71 232.0 COG1295@1|root,COG1295@2|Bacteria,1QICW@1224|Proteobacteria,1RMKI@1236|Gammaproteobacteria,1J640@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Virulence factor BrkB rbn - - ko:K07058 - - - - ko00000 - - - Virul_fac_BrkB k59_626043_2 522373.Smlt4318 4.6e-56 183.0 COG0152@1|root,COG0152@2|Bacteria,1MUR9@1224|Proteobacteria,1RNNY@1236|Gammaproteobacteria,1X3PE@135614|Xanthomonadales 135614|Xanthomonadales F Belongs to the SAICAR synthetase family purC GO:0003674,GO:0003824,GO:0004639,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006188,GO:0006189,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.2.6 ko:K01923 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04591 RC00064,RC00162 ko00000,ko00001,ko00002,ko01000 - - - SAICAR_synt k59_1643202_2 330214.NIDE0815 7.86e-36 144.0 COG0642@1|root,COG0745@1|root,COG0784@1|root,COG2203@1|root,COG3829@1|root,COG0642@2|Bacteria,COG0745@2|Bacteria,COG0784@2|Bacteria,COG2203@2|Bacteria,COG3829@2|Bacteria,3J0ZF@40117|Nitrospirae 2|Bacteria T Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - - - - - - - - - - CHASE8,GAF,GAF_2,HAMP,HATPase_c,HisKA,Hpt,PAS,PAS_3,PAS_4,PAS_9,Response_reg,SBP_bac_3 k59_1699511_1 568706.BN118_3010 4.93e-92 275.0 COG0088@1|root,COG0088@2|Bacteria,1MXPF@1224|Proteobacteria,2VHS6@28216|Betaproteobacteria,3T25A@506|Alcaligenaceae 28216|Betaproteobacteria J Forms part of the polypeptide exit tunnel rplD - - ko:K02926 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L4 k59_400258_1 404589.Anae109_2748 3.84e-116 360.0 COG0493@1|root,COG0543@1|root,COG1633@1|root,COG0493@2|Bacteria,COG0543@2|Bacteria,COG1633@2|Bacteria,1MU2H@1224|Proteobacteria,42MGY@68525|delta/epsilon subdivisions,2WJHC@28221|Deltaproteobacteria 28221|Deltaproteobacteria C TIGRFAM glutamate synthase (NADPH), homotetrameric nfnA - 1.4.1.13,1.4.1.14 ko:K00266 ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 - R00093,R00114,R00248 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - DHODB_Fe-S_bind,Fer4_20,Pyr_redox_2 k59_1022094_1 1121396.KB892930_gene3628 4.57e-13 76.3 COG1629@1|root,COG4771@2|Bacteria,1MWKN@1224|Proteobacteria,42MNM@68525|delta/epsilon subdivisions,2WMEW@28221|Deltaproteobacteria,2MMGV@213118|Desulfobacterales 28221|Deltaproteobacteria P TonB dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_513045_1 1279017.AQYJ01000026_gene65 1.12e-56 202.0 COG4105@1|root,COG4105@2|Bacteria,1QVQ9@1224|Proteobacteria,1RSIG@1236|Gammaproteobacteria,46DC5@72275|Alteromonadaceae 1236|Gammaproteobacteria S Tetratricopeptide repeat - - - - - - - - - - - - TPR_16,TPR_6 k59_1530062_1 436308.Nmar_0476 4.29e-69 215.0 COG0842@1|root,arCOG01467@2157|Archaea,41SQQ@651137|Thaumarchaeota 651137|Thaumarchaeota V PFAM ABC-2 type transporter - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane k59_287511_1 1522072.IL54_1076 2.51e-40 155.0 COG3408@1|root,COG3408@2|Bacteria,1NJCP@1224|Proteobacteria,2U1JA@28211|Alphaproteobacteria,2K33N@204457|Sphingomonadales 204457|Sphingomonadales G Bacterial alpha-L-rhamnosidase C-terminal domain - - 3.2.1.40 ko:K05989 - - - - ko00000,ko01000 - - - Bac_rhamnosid,Bac_rhamnosid6H,Bac_rhamnosid_C,Bac_rhamnosid_N k59_1474646_1 394221.Mmar10_1648 2.35e-80 248.0 COG1028@1|root,COG1028@2|Bacteria,1MXNQ@1224|Proteobacteria,2TS6G@28211|Alphaproteobacteria,43W8V@69657|Hyphomonadaceae 28211|Alphaproteobacteria IQ Belongs to the short-chain dehydrogenases reductases (SDR) family MA20_27450 - - - - - - - - - - - adh_short k59_627084_1 314285.KT71_11129 7.12e-07 50.4 COG0477@1|root,COG2814@2|Bacteria,1MVVW@1224|Proteobacteria 1224|Proteobacteria EGP Major facilitator Superfamily - - - - - - - - - - - - MFS_1 k59_627084_2 1357399.HMPREF2087_00838 2e-17 83.2 COG0786@1|root,COG0786@2|Bacteria,1MVBC@1224|Proteobacteria,42P9U@68525|delta/epsilon subdivisions,2YN8S@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria P Catalyzes the sodium-dependent transport of glutamate gltS - - ko:K03312 - - - - ko00000,ko02000 2.A.27 - iIT341.HP1506 Glt_symporter k59_965953_1 935863.AWZR01000013_gene1543 9.79e-96 291.0 COG0012@1|root,COG0012@2|Bacteria,1MVM4@1224|Proteobacteria,1RMBI@1236|Gammaproteobacteria,1X3B7@135614|Xanthomonadales 135614|Xanthomonadales J ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner ychF - - ko:K06942 - - - - ko00000,ko03009 - - - MMR_HSR1,YchF-GTPase_C k59_1644180_2 289376.THEYE_A1153 7.82e-63 201.0 COG0115@1|root,COG0115@2|Bacteria,3J0BM@40117|Nitrospirae 40117|Nitrospirae E Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family ilvE - 2.6.1.42 ko:K00826 ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00036,M00119,M00570 R01090,R01214,R02199,R10991 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_4 k59_1700400_1 742733.HMPREF9469_01033 5.73e-09 58.2 COG2207@1|root,COG2207@2|Bacteria,1UYDC@1239|Firmicutes,25KPH@186801|Clostridia,22190@1506553|Lachnoclostridium 186801|Clostridia K AraC-like ligand binding domain - - - - - - - - - - - - AraC_binding,HTH_18 k59_1700400_2 754035.Mesau_04964 1.41e-64 207.0 COG2010@1|root,COG2010@2|Bacteria,1MV6D@1224|Proteobacteria,2TT9U@28211|Alphaproteobacteria,43IDK@69277|Phyllobacteriaceae 28211|Alphaproteobacteria C Cytochrome c cycG GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - - - - - - - - - - Cytochrom_C k59_1135448_2 1217714.F975_01522 8.45e-07 52.0 COG0560@1|root,COG0560@2|Bacteria,1MXGP@1224|Proteobacteria,1RQNV@1236|Gammaproteobacteria,3NJEE@468|Moraxellaceae 1236|Gammaproteobacteria E haloacid dehalogenase-like hydrolase cicA - - - - - - - - - - - HAD k59_352042_1 1042375.AFPL01000035_gene2831 1.86e-56 186.0 28RZD@1|root,2ZEBA@2|Bacteria,1RBEH@1224|Proteobacteria,1RP8T@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_1030309_1 1144319.PMI16_04759 1.84e-20 96.3 COG3170@1|root,COG3170@2|Bacteria,1MXV7@1224|Proteobacteria,2VHX1@28216|Betaproteobacteria,473WU@75682|Oxalobacteraceae 28216|Betaproteobacteria NU LysM domain fimV - - ko:K08086 - - - - ko00000 - - - LysM k59_69807_2 436308.Nmar_1633 3.3e-10 59.3 COG0388@1|root,arCOG00062@2157|Archaea,41SF8@651137|Thaumarchaeota 651137|Thaumarchaeota S Carbon-nitrogen hydrolase - - - ko:K11206 - - - - ko00000,ko01000 - - - CN_hydrolase k59_577462_1 395964.KE386496_gene3277 1.07e-65 213.0 2DBWE@1|root,2ZBGD@2|Bacteria,1R6MH@1224|Proteobacteria,2UP6E@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_860884_1 1280950.HJO_13046 2.21e-100 306.0 COG2072@1|root,COG2072@2|Bacteria,1MU71@1224|Proteobacteria,2TV2E@28211|Alphaproteobacteria,43ZBN@69657|Hyphomonadaceae 28211|Alphaproteobacteria P flavoprotein involved in K transport MA20_23085 - - - - - - - - - - - FMO-like,K_oxygenase,NAD_binding_8,Pyr_redox_2 k59_1482238_1 765914.ThisiDRAFT_0180 3.99e-80 255.0 COG1171@1|root,COG1171@2|Bacteria,1MVWJ@1224|Proteobacteria,1RMY6@1236|Gammaproteobacteria,1WWPJ@135613|Chromatiales 135613|Chromatiales E Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA ilvA - 4.3.1.19 ko:K01754 ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230 M00570 R00220,R00996 RC00418,RC02600 ko00000,ko00001,ko00002,ko01000 - - - PALP,Thr_dehydrat_C k59_633760_1 1453501.JELR01000002_gene326 1.37e-22 96.7 COG1629@1|root,COG4206@1|root,COG4206@2|Bacteria,COG4771@2|Bacteria,1MU9K@1224|Proteobacteria,1RMTG@1236|Gammaproteobacteria,464NB@72275|Alteromonadaceae 1236|Gammaproteobacteria P Outer membrane receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_633760_2 1282361.ABAC402_11355 4.65e-14 73.9 COG0457@1|root,COG0457@2|Bacteria,1R3PU@1224|Proteobacteria,2U3HS@28211|Alphaproteobacteria,2KHKE@204458|Caulobacterales 204458|Caulobacterales S Sulfotransferase domain - - - - - - - - - - - - Sulfotransfer_3,TPR_16 k59_1312423_1 338963.Pcar_1100 4.42e-51 183.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42Z4K@68525|delta/epsilon subdivisions,2WU8P@28221|Deltaproteobacteria 28221|Deltaproteobacteria U Protein export membrane protein - - - - - - - - - - - - ACR_tran k59_1424496_1 1260251.SPISAL_01225 1.55e-26 112.0 COG1198@1|root,COG1198@2|Bacteria,1MUUZ@1224|Proteobacteria,1RPZ7@1236|Gammaproteobacteria,1WX60@135613|Chromatiales 135613|Chromatiales L Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA priA - - ko:K04066 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,Helicase_C,ResIII k59_860901_1 436308.Nmar_0193 8.67e-30 115.0 COG0527@1|root,arCOG00861@2157|Archaea,41SFK@651137|Thaumarchaeota 651137|Thaumarchaeota E Amino acid kinase family - - 2.7.2.4 ko:K00928 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00017,M00018,M00033,M00525,M00526,M00527 R00480 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase k59_916346_1 410358.Mlab_0203 5.83e-06 51.6 COG1945@1|root,arCOG04490@2157|Archaea 2157|Archaea S Pyruvoyl-dependent arginine decarboxylase pdaD - 4.1.1.19 ko:K02626 ko00330,ko01100,map00330,map01100 M00133 R00566 RC00299 ko00000,ko00001,ko00002,ko01000 - - - PvlArgDC k59_238137_1 1173029.JH980292_gene4116 2.76e-17 82.4 COG0712@1|root,COG0712@2|Bacteria,1G5SS@1117|Cyanobacteria,1HB3Q@1150|Oscillatoriales 1117|Cyanobacteria C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation atpD GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0016020,GO:0016469,GO:0032991,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0045259,GO:0045260,GO:0071944,GO:0098796,GO:0098797 - ko:K02113 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - OSCP k59_860903_1 1122137.AQXF01000001_gene2579 2.31e-98 313.0 COG2931@1|root,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,2U7AB@28211|Alphaproteobacteria 28211|Alphaproteobacteria MQ Haemolysin-type calcium-binding repeat (2 copies) - - - - - - - - - - - - HemolysinCabind k59_12831_1 1232410.KI421420_gene3156 6.54e-29 120.0 COG1391@1|root,COG1391@2|Bacteria,1MU4I@1224|Proteobacteria,42MCT@68525|delta/epsilon subdivisions,2WINW@28221|Deltaproteobacteria,43T20@69541|Desulfuromonadales 28221|Deltaproteobacteria H Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell glnE - 2.7.7.42,2.7.7.89 ko:K00982 - - - - ko00000,ko01000 - - - GlnD_UR_UTase,GlnE k59_1482253_1 1121912.AUHD01000008_gene175 2.57e-36 132.0 COG0470@1|root,COG0470@2|Bacteria,4NEYF@976|Bacteroidetes,1HXGT@117743|Flavobacteriia 976|Bacteroidetes L DNA polymerase III holB - 2.7.7.7 ko:K02341 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_delta2 k59_1482253_2 1197477.IA57_05370 1.57e-69 218.0 28PKM@1|root,2ZCA0@2|Bacteria,4NHEG@976|Bacteroidetes,1I1K5@117743|Flavobacteriia 976|Bacteroidetes S Domain of unknown function (DUF4249) - - - - - - - - - - - - DUF4249 k59_12835_1 1121374.KB891576_gene488 1.08e-164 468.0 COG0714@1|root,COG0714@2|Bacteria,1MUFN@1224|Proteobacteria,1RN5G@1236|Gammaproteobacteria 1236|Gammaproteobacteria S PFAM ATPase associated with various cellular activities moxR - - ko:K03924 - - - - ko00000,ko01000 - - - AAA_3 k59_408052_1 1498011.A0A096XUS7_9CAUD 2.18e-61 214.0 4QAUF@10239|Viruses,4QQIV@28883|Caudovirales,4QNZ6@10744|Podoviridae 10744|Podoviridae - - - - - - - - - - - - - - - k59_1424519_1 870187.Thini_0765 3.05e-11 63.5 COG0079@1|root,COG0079@2|Bacteria,1MW7I@1224|Proteobacteria,1RP4T@1236|Gammaproteobacteria,45ZT5@72273|Thiotrichales 72273|Thiotrichales E Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily - - 2.6.1.9 ko:K00817 ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230 M00026 R00694,R00734,R03243 RC00006,RC00888 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 k59_1424519_2 1333856.L686_22610 3.54e-31 125.0 COG0128@1|root,COG0287@1|root,COG0128@2|Bacteria,COG0287@2|Bacteria,1MWMK@1224|Proteobacteria,1RQ8U@1236|Gammaproteobacteria,1Z1RM@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria E Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate aroA - 1.3.1.12,1.3.1.43,2.5.1.19 ko:K00210,ko:K00220,ko:K00800 ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230 M00022,M00025,M00040 R00732,R01728,R03460 RC00125,RC00350 ko00000,ko00001,ko00002,ko01000 - - - EPSP_synthase,PDH k59_1482256_1 1123236.KB899380_gene2930 2.28e-12 75.5 COG0642@1|root,COG0784@1|root,COG0784@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,1SKTW@1236|Gammaproteobacteria,463ZD@72275|Alteromonadaceae 1236|Gammaproteobacteria T COG0642 Signal transduction histidine kinase - - - - - - - - - - - - CBS,HATPase_c,HisKA,Hpt,PAS_3,Response_reg k59_1482256_2 1127673.GLIP_3027 7.18e-20 88.2 COG0687@1|root,COG0687@2|Bacteria,1MW93@1224|Proteobacteria,1RM81@1236|Gammaproteobacteria,464PU@72275|Alteromonadaceae 1236|Gammaproteobacteria E Spermidine putrescine-binding periplasmic protein - - - ko:K02055 ko02024,map02024 M00193 - - ko00000,ko00001,ko00002,ko02000 3.A.1.11 - - SBP_bac_8 k59_1312438_1 1500306.JQLA01000007_gene6294 7.97e-73 221.0 COG3565@1|root,COG3565@2|Bacteria,1RD7C@1224|Proteobacteria,2U78G@28211|Alphaproteobacteria,4BDZK@82115|Rhizobiaceae 28211|Alphaproteobacteria S Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - ko:K06991 - - - - ko00000 - - - Glyoxalase k59_408054_1 316407.85675768 1.59e-11 62.4 28H6P@1|root,2Z7J1@2|Bacteria,1MXU1@1224|Proteobacteria,1RPHU@1236|Gammaproteobacteria,3XMGC@561|Escherichia 1236|Gammaproteobacteria S Protein of unknown function (DUF2884) yggN - - - - - - - - - - - DUF2884 k59_408054_2 316407.85675767 1.01e-134 388.0 COG0252@1|root,COG0252@2|Bacteria,1MWIR@1224|Proteobacteria,1RNPN@1236|Gammaproteobacteria,3XP5U@561|Escherichia 1236|Gammaproteobacteria EJ Belongs to the asparaginase 1 family ansB GO:0003674,GO:0003824,GO:0004067,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006528,GO:0006530,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009064,GO:0009065,GO:0009066,GO:0009068,GO:0009987,GO:0016043,GO:0016054,GO:0016787,GO:0016810,GO:0016811,GO:0019752,GO:0022607,GO:0030288,GO:0030313,GO:0031975,GO:0032787,GO:0034641,GO:0042597,GO:0042802,GO:0043436,GO:0043603,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0065003,GO:0071704,GO:0071840,GO:0072329,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 3.5.1.1,3.5.1.38 ko:K01424,ko:K05597 ko00220,ko00250,ko00460,ko00471,ko01100,ko01110,ko02020,map00220,map00250,map00460,map00471,map01100,map01110,map02020 - R00256,R00485,R01579 RC00010,RC02798 ko00000,ko00001,ko01000 - - - Asparaginase k59_182109_1 1121943.KB899994_gene916 3.01e-59 192.0 COG4535@1|root,COG4535@2|Bacteria,1QTU8@1224|Proteobacteria,1RMKX@1236|Gammaproteobacteria,1XHEY@135619|Oceanospirillales 135619|Oceanospirillales P transporter corC - - ko:K06189 - - - - ko00000,ko02000 9.A.40.1.2 - - CBS,CorC_HlyC k59_1594318_1 247634.GPB2148_783 3.06e-20 88.2 COG2863@1|root,COG2863@2|Bacteria,1QXWH@1224|Proteobacteria,1T3IQ@1236|Gammaproteobacteria,1J6M9@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C COG2863 Cytochrome c553 - - - - - - - - - - - - Cytochrom_C,ThuA k59_1594318_2 234267.Acid_4305 2.18e-23 95.9 2DBN7@1|root,2ZA2Y@2|Bacteria 2|Bacteria S Domain of unknown function (DUF4159) - - - - - - - - - - - - DUF4159 k59_577486_1 319224.Sputcn32_2871 8.72e-13 68.2 COG2951@1|root,COG2951@2|Bacteria,1MUZ3@1224|Proteobacteria,1RMQ6@1236|Gammaproteobacteria,2Q95Q@267890|Shewanellaceae 1236|Gammaproteobacteria M TIGRFAM lytic murein transglycosylase B mltB - - ko:K08305 - - - - ko00000,ko01000,ko01011 - GH103 - SLT_2 k59_577486_2 1415778.JQMM01000001_gene1024 1.25e-82 254.0 COG0797@1|root,COG0797@2|Bacteria,1MZ8S@1224|Proteobacteria,1RMCG@1236|Gammaproteobacteria,1J5ZU@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides rlpA GO:0005575,GO:0005623,GO:0009279,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0044462,GO:0044464,GO:0071944 - ko:K03642 - - - - ko00000 - - - DPBB_1,SPOR k59_1651094_1 195250.CM001776_gene952 2.94e-89 273.0 COG4974@1|root,COG4974@2|Bacteria,1G4JW@1117|Cyanobacteria,1GZF3@1129|Synechococcus 1117|Cyanobacteria L Phage integrase, N-terminal SAM-like domain - - - ko:K04763 - - - - ko00000,ko03036 - - - Phage_int_SAM_1,Phage_int_SAM_4,Phage_integrase k59_69858_1 502025.Hoch_3889 3.02e-82 263.0 COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,42MHP@68525|delta/epsilon subdivisions,2WIQG@28221|Deltaproteobacteria,2YUFQ@29|Myxococcales 28221|Deltaproteobacteria H Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA - - 6.2.1.1,6.2.1.16 ko:K01895,ko:K01907 ko00010,ko00280,ko00620,ko00640,ko00650,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00280,map00620,map00640,map00650,map00680,map00720,map01100,map01110,map01120,map01130,map01200 M00357 R00235,R00236,R00316,R00926,R01354,R01357 RC00004,RC00012,RC00014,RC00043,RC00070,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000,ko01004 - - - ACAS_N,AMP-binding,AMP-binding_C k59_295615_1 187272.Mlg_1959 1.25e-81 261.0 COG1009@1|root,COG1009@2|Bacteria,1MW2M@1224|Proteobacteria,1RNKN@1236|Gammaproteobacteria,1WWQ6@135613|Chromatiales 135613|Chromatiales CP NADH-Ubiquinone oxidoreductase (complex I) chain 5 L domain protein - - 1.6.5.3 ko:K00341 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Proton_antipo_M,Proton_antipo_N k59_1594330_1 13690.CP98_03900 2.32e-54 178.0 COG2141@1|root,COG2141@2|Bacteria,1N4HT@1224|Proteobacteria,2UEZB@28211|Alphaproteobacteria,2K3VA@204457|Sphingomonadales 204457|Sphingomonadales C Luciferase-like monooxygenase - - - - - - - - - - - - Bac_luciferase k59_182136_1 1042377.AFPJ01000004_gene393 7.1e-110 342.0 COG1574@1|root,COG1574@2|Bacteria,1MWP2@1224|Proteobacteria,1RNB7@1236|Gammaproteobacteria,464KP@72275|Alteromonadaceae 1236|Gammaproteobacteria S metal-dependent hydrolase with the TIM-barrel fold - - - - - - - - - - - - Amidohydro_3 k59_1312457_1 330214.NIDE4254 3.57e-120 355.0 COG0624@1|root,COG0624@2|Bacteria 2|Bacteria E succinyl-diaminopimelate desuccinylase activity - - - - - - - - - - - - M20_dimer,Peptidase_M20 k59_860950_2 1297742.A176_04149 5.04e-13 71.6 COG0494@1|root,COG0494@2|Bacteria,1RCX7@1224|Proteobacteria,42UR1@68525|delta/epsilon subdivisions,2WQUD@28221|Deltaproteobacteria,2YVF3@29|Myxococcales 28221|Deltaproteobacteria L NUDIX domain nudF - - - - - - - - - - - NUDIX k59_972202_1 1459636.NTE_03246 4.81e-90 287.0 COG1132@1|root,arCOG02841@2157|Archaea 2157|Archaea V COG1132 ABC-type multidrug transport system, ATPase and permease components trp1 - - ko:K02068,ko:K06147,ko:K06148,ko:K11085 ko02010,map02010 M00211 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1,3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran k59_1538270_1 388413.ALPR1_09705 1.37e-11 69.7 COG3119@1|root,COG3119@2|Bacteria,4NEZJ@976|Bacteroidetes 976|Bacteroidetes P arylsulfatase A - - - - - - - - - - - - HEAT_2,Sulfatase k59_577501_1 1123269.NX02_18955 0.000403 41.6 COG4638@1|root,COG4638@2|Bacteria,1MV2G@1224|Proteobacteria 1224|Proteobacteria P Rieske 2Fe2S - - 1.14.12.22,1.14.12.7 ko:K15751,ko:K18068 ko00621,ko00624,ko01100,ko01120,ko01220,map00621,map00624,map01100,map01120,map01220 M00544,M00623 R03630,R05414,R09512 RC00951,RC01370 br01602,ko00000,ko00001,ko00002,ko01000 - - - Aromatic_hydrox,Rieske k59_577501_2 1123279.ATUS01000001_gene1682 3.04e-55 181.0 COG3971@1|root,COG3971@2|Bacteria,1MVVV@1224|Proteobacteria,1RMZ4@1236|Gammaproteobacteria 1236|Gammaproteobacteria Q hydratase mhpD GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0008150,GO:0008152,GO:0008684,GO:0009056,GO:0009987,GO:0016829,GO:0016835,GO:0016836,GO:0019439,GO:0030145,GO:0042802,GO:0043167,GO:0043169,GO:0044237,GO:0044248,GO:0044424,GO:0044464,GO:0046872,GO:0046914 4.2.1.80 ko:K02554 ko00360,ko00362,ko00621,ko00622,ko01100,ko01120,ko01220,map00360,map00362,map00621,map00622,map01100,map01120,map01220 M00545,M00569 R02601,R04781 RC00750,RC01213 br01602,ko00000,ko00001,ko00002,ko01000 - - iECO111_1330.ECO111_0386,iECO26_1355.ECO26_0386,iECW_1372.ECW_m0428,iEKO11_1354.EKO11_3492,iEcE24377_1341.EcE24377A_0374,iEcHS_1320.EcHS_A0414,iWFL_1372.ECW_m0428 FAA_hydrolase k59_690360_1 391598.FBBAL38_03985 1.42e-93 295.0 COG1554@1|root,COG1554@2|Bacteria,4NFG1@976|Bacteroidetes,1HXBI@117743|Flavobacteriia 976|Bacteroidetes G hydrolase, family 65, central catalytic - - 2.4.1.8 ko:K00691 ko00500,ko01100,map00500,map01100 - R01555 RC00049 ko00000,ko00001,ko01000 - GH65 - Glyco_hydro_65C,Glyco_hydro_65N,Glyco_hydro_65m k59_916387_1 502025.Hoch_0336 3.19e-20 87.8 COG0491@1|root,COG0491@2|Bacteria,1R4FA@1224|Proteobacteria,42TJ6@68525|delta/epsilon subdivisions,2WR3Z@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Metallo-beta-lactamase superfamily - - - - - - - - - - - - Lactamase_B k59_1538285_1 1121861.KB899916_gene1731 2.58e-61 212.0 COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,2TQMW@28211|Alphaproteobacteria,2JQY7@204441|Rhodospirillales 204441|Rhodospirillales C Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain - - 1.2.5.3 ko:K03520 - - R11168 RC02800 ko00000,ko01000 - - - Ald_Xan_dh_C,Ald_Xan_dh_C2 k59_1085627_1 472759.Nhal_2012 9.61e-82 268.0 COG0045@1|root,COG0454@1|root,COG1042@1|root,COG0045@2|Bacteria,COG0456@2|Bacteria,COG1042@2|Bacteria,1MW98@1224|Proteobacteria,1RPXX@1236|Gammaproteobacteria,1WWWU@135613|Chromatiales 135613|Chromatiales C CoA-binding domain protein - - - ko:K09181 - - - - ko00000 - - - ATP-grasp_5,Acetyltransf_1,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig k59_464398_1 436308.Nmar_1191 1.07e-113 345.0 COG1331@1|root,arCOG02007@2157|Archaea,41SHZ@651137|Thaumarchaeota 651137|Thaumarchaeota O Protein of unknown function, DUF255 - - - ko:K06888 - - - - ko00000 - - - Thioredox_DsbH k59_464398_2 436308.Nmar_1192 4.24e-25 95.1 arCOG08692@1|root,arCOG08692@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_1030387_1 936375.HMPREF1152_1694 3.29e-05 48.5 COG0584@1|root,COG0584@2|Bacteria,1V3W4@1239|Firmicutes,24AVJ@186801|Clostridia,3WD9W@538999|Clostridiales incertae sedis 186801|Clostridia C PFAM Glycerophosphoryl diester phosphodiesterase family - - 3.1.4.46 ko:K01126 ko00564,map00564 - R01030,R01470 RC00017,RC00425 ko00000,ko00001,ko01000 - - - GDPD k59_1312478_2 314287.GB2207_10908 1.38e-30 120.0 COG0665@1|root,COG0665@2|Bacteria,1QVH0@1224|Proteobacteria,1T2DK@1236|Gammaproteobacteria,1JC25@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 mnmC GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0003824,GO:0004808,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016491,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0055114,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.1.1.61 ko:K15461 - - R00601,R08702 RC00003,RC00053,RC00060,RC01483 ko00000,ko01000,ko03016 - - - DAO k59_1763851_1 472759.Nhal_3083 2.52e-25 103.0 COG4257@1|root,COG4257@2|Bacteria,1QR8W@1224|Proteobacteria,1RQM4@1236|Gammaproteobacteria,1X0DH@135613|Chromatiales 135613|Chromatiales V Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2-amino-butenoic acid - - - ko:K18235 - - - - ko00000,ko01000,ko01504 - - - - k59_1763851_2 1282362.AEAC466_07545 1.24e-10 67.0 COG0845@1|root,COG0845@2|Bacteria,1MU78@1224|Proteobacteria,2TSW4@28211|Alphaproteobacteria,2KI69@204458|Caulobacterales 204458|Caulobacterales M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - ko:K03585 ko01501,ko01503,map01501,map01503 M00646,M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000,ko03036 2.A.6.2,8.A.1.6 - - HlyD_D23 k59_1198970_1 1127673.GLIP_0453 2.58e-39 150.0 COG1629@1|root,COG4771@2|Bacteria,1MU9K@1224|Proteobacteria,1RMTG@1236|Gammaproteobacteria,465TV@72275|Alteromonadaceae 1236|Gammaproteobacteria P COG1629 Outer membrane receptor proteins, mostly Fe transport - - - - - - - - - - - - Plug,TonB_dep_Rec k59_408125_4 1229204.AMYY01000017_gene1298 1.51e-10 65.9 COG0582@1|root,COG0582@2|Bacteria,1NH8M@1224|Proteobacteria,2TUHG@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Belongs to the 'phage' integrase family - - - - - - - - - - - - Phage_integrase k59_183381_1 1296990.H845_1155 3.23e-26 112.0 COG0665@1|root,COG0665@2|Bacteria,1QWQF@1224|Proteobacteria,2U1W6@28211|Alphaproteobacteria 28211|Alphaproteobacteria E NAD(P)-binding Rossmann-like domain - - 1.5.99.6 ko:K00316 ko00330,ko00410,ko01100,map00330,map00410,map01100 - R01914,R01915 RC00053,RC00225 ko00000,ko00001,ko01000 - - - NAD_binding_8 k59_1764961_1 1229909.NSED_08345 5.52e-44 147.0 arCOG04405@1|root,arCOG04405@2157|Archaea 2157|Archaea S ASCH domain - - - - - - - - - - - - ASCH k59_917572_1 247634.GPB2148_2840 6.97e-78 245.0 COG3007@1|root,COG3007@2|Bacteria,1MWCQ@1224|Proteobacteria,1RPPP@1236|Gammaproteobacteria,1J56E@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria I Involved in the final reduction of the elongation cycle of fatty acid synthesis (FAS II). Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP) fabV GO:0000166,GO:0003674,GO:0003824,GO:0004312,GO:0004318,GO:0005488,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0032787,GO:0036094,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0071704,GO:0072330,GO:0097159,GO:1901265,GO:1901363,GO:1901576 1.3.1.44,1.3.1.9 ko:K00209 ko00061,ko00650,ko01100,ko01120,ko01200,ko01212,map00061,map00650,map01100,map01120,map01200,map01212 M00083 R01171,R04429,R04724,R04955,R04958,R04961,R04966,R04969 RC00052,RC00076 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Eno-Rase_FAD_bd,Eno-Rase_NADH_b,Enoyl_reductase k59_1256517_1 420324.KI912045_gene4255 1.08e-73 238.0 COG3409@1|root,COG3409@2|Bacteria,1RAYU@1224|Proteobacteria,2U6D1@28211|Alphaproteobacteria 28211|Alphaproteobacteria M N-acetylmuramidase - - - - - - - - - - - - Muraidase,PG_binding_1 k59_578608_2 314285.KT71_16711 6.81e-42 150.0 2EFR2@1|root,31TEB@2|Bacteria,1QR4A@1224|Proteobacteria,1SMNZ@1236|Gammaproteobacteria,1J8Z7@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_578608_3 1313304.CALK_0880 0.00014 43.9 COG2885@1|root,COG2885@2|Bacteria 2|Bacteria M chlorophyll binding - - - ko:K16191 - - - - ko00000,ko02000 1.B.6.1.3 - - OmpA k59_917578_1 555778.Hneap_0334 7.14e-06 45.8 COG0198@1|root,COG0198@2|Bacteria,1MZQD@1224|Proteobacteria,1S973@1236|Gammaproteobacteria,1WYKG@135613|Chromatiales 135613|Chromatiales J One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit rplX - - ko:K02895 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - KOW,ribosomal_L24 k59_917578_3 491952.Mar181_3343 1.66e-12 63.5 COG0199@1|root,COG0199@2|Bacteria,1MZDT@1224|Proteobacteria,1S62N@1236|Gammaproteobacteria,1XKDP@135619|Oceanospirillales 135619|Oceanospirillales J Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site rpsN - - ko:K02954 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S14 k59_183404_1 1469613.JT55_05170 2.71e-30 125.0 COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2TR2W@28211|Alphaproteobacteria,3FE05@34008|Rhodovulum 28211|Alphaproteobacteria IQ AMP-binding enzyme C-terminal domain - - 6.2.1.3 ko:K00666,ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding,AMP-binding_C k59_521616_1 1415778.JQMM01000001_gene2035 7.54e-79 252.0 COG0028@1|root,COG0028@2|Bacteria,1QMA9@1224|Proteobacteria,1RRRN@1236|Gammaproteobacteria,1J9TV@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria EH Thiamine pyrophosphate enzyme, central domain - - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_1200209_1 545695.TREAZ_0346 3.47e-67 226.0 COG2256@1|root,COG2256@2|Bacteria,2J604@203691|Spirochaetes 203691|Spirochaetes L COG2256 ATPase related to the helicase subunit of the Holliday junction resolvase - - - ko:K07478 - - - - ko00000 - - - AAA,AAA_assoc_2,MgsA_C,RuvB_N k59_635077_1 1454004.AW11_02692 3.13e-89 278.0 COG0168@1|root,COG0168@2|Bacteria,1MUIJ@1224|Proteobacteria,2VH82@28216|Betaproteobacteria,1KQBC@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria P Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA trkH - - ko:K03498 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - - TrkH k59_691600_1 158500.BV97_01291 1.37e-39 149.0 COG1629@1|root,COG1629@2|Bacteria,COG4771@2|Bacteria,1MU9K@1224|Proteobacteria,2UNZR@28211|Alphaproteobacteria,2KECI@204457|Sphingomonadales 204457|Sphingomonadales P TonB dependent receptor - - - - - - - - - - - - Plug,TonB_dep_Rec k59_1031367_2 1033802.SSPSH_003548 5.88e-24 100.0 COG0067@1|root,COG0069@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,1MU7B@1224|Proteobacteria,1RN2W@1236|Gammaproteobacteria 1236|Gammaproteobacteria E Glutamate synthase gltB GO:0003674,GO:0003824,GO:0004355,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006541,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0015930,GO:0016053,GO:0016491,GO:0016638,GO:0016639,GO:0019676,GO:0019740,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045181,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.4.1.13,1.4.1.14 ko:K00265 ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 - R00093,R00114,R00248 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - iBWG_1329.BWG_2914,iECDH10B_1368.ECDH10B_3387,iECDH1ME8569_1439.EcDH1_0495,iEcDH1_1363.EcDH1_0495,iPC815.YPO3557 GATase_2,GXGXG,Glu_syn_central,Glu_synthase k59_1764975_1 529884.Rhola_00007200 3.02e-63 215.0 COG0317@1|root,COG0317@2|Bacteria,2GJYQ@201174|Actinobacteria,4FMKK@85023|Microbacteriaceae 201174|Actinobacteria KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance relA GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0007154,GO:0008150,GO:0008152,GO:0008728,GO:0008893,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009150,GO:0009152,GO:0009163,GO:0009165,GO:0009259,GO:0009260,GO:0009267,GO:0009405,GO:0009605,GO:0009987,GO:0009991,GO:0015968,GO:0015969,GO:0015970,GO:0016020,GO:0016740,GO:0016772,GO:0016778,GO:0016787,GO:0016788,GO:0016794,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030145,GO:0030312,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034035,GO:0034036,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0042578,GO:0042594,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044419,GO:0044464,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0046872,GO:0046914,GO:0050896,GO:0051704,GO:0051716,GO:0055086,GO:0071496,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.7.6.5,3.1.7.2 ko:K00951,ko:K01139 ko00230,map00230 - R00336,R00429 RC00002,RC00078 ko00000,ko00001,ko01000,ko03009 - - - ACT_4,HD_4,RelA_SpoT,TGS k59_1086966_2 998674.ATTE01000001_gene3865 2.18e-96 285.0 COG1435@1|root,COG1435@2|Bacteria,1NJR4@1224|Proteobacteria,1RPCK@1236|Gammaproteobacteria,460UE@72273|Thiotrichales 72273|Thiotrichales F deoxynucleoside kinase activity tdk - 2.7.1.21 ko:K00857 ko00240,ko00983,ko01100,map00240,map00983,map01100 - R01567,R02099,R08233 RC00002,RC00017 ko00000,ko00001,ko01000 - - - TK k59_465533_1 1449076.JOOE01000001_gene2027 4.35e-74 236.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,2TQR7@28211|Alphaproteobacteria,2K0BV@204457|Sphingomonadales 204457|Sphingomonadales NT methyl-accepting chemotaxis protein - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - CHASE3,MCPsignal,dCache_1 k59_127138_1 1122137.AQXF01000004_gene1542 3.92e-58 193.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,2U0XK@28211|Alphaproteobacteria 28211|Alphaproteobacteria NT methyl-accepting chemotaxis protein - - - - - - - - - - - - MCPsignal k59_127138_2 1122137.AQXF01000004_gene1543 6.09e-63 196.0 COG3829@1|root,COG3829@2|Bacteria,1RH32@1224|Proteobacteria,2U79H@28211|Alphaproteobacteria 28211|Alphaproteobacteria KT COG2202 FOG PAS PAC domain - - - - - - - - - - - - PAS,PAS_3 k59_1708338_1 1415778.JQMM01000001_gene1474 1.17e-50 181.0 COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,1RN2C@1236|Gammaproteobacteria,1J595@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P cation transport ATPase ccoI - 3.6.3.4 ko:K01533 - - R00086 RC00002 ko00000,ko01000 3.A.3.5 - - ATPase-cat_bd,E1-E2_ATPase,HMA,Hydrolase k59_1661658_1 436308.Nmar_1490 7.91e-201 560.0 COG0180@1|root,arCOG01887@2157|Archaea,41SDK@651137|Thaumarchaeota 651137|Thaumarchaeota J Belongs to the class-I aminoacyl-tRNA synthetase family - - 6.1.1.2 ko:K01867 ko00970,map00970 M00359,M00360 R03664 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_1b k59_1661658_2 1229909.NSED_08195 2.77e-15 75.1 COG0016@1|root,arCOG00410@2157|Archaea,41S9U@651137|Thaumarchaeota 651137|Thaumarchaeota J Phenylalanyl-tRNA synthetase alpha subunit - - 6.1.1.20 ko:K01889 ko00970,map00970 M00359,M00360 R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_2d k59_981995_1 743720.Psefu_4091 2.43e-107 332.0 COG1032@1|root,COG1032@2|Bacteria,1MUG3@1224|Proteobacteria,1RN9V@1236|Gammaproteobacteria,1YWNZ@136845|Pseudomonas putida group 1236|Gammaproteobacteria C UPF0313 protein ygiQ - - - - - - - - - - - DUF3362,Radical_SAM,Radical_SAM_N k59_81217_1 161528.ED21_18202 1.12e-20 89.7 COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,2TREJ@28211|Alphaproteobacteria,2K1PX@204457|Sphingomonadales 204457|Sphingomonadales I Catalyzes the formation of 3-methylbut-2-enoyl CoA from 3-methylbutanoyl CoA - - 1.3.8.4 ko:K00253 ko00280,ko01100,map00280,map01100 M00036 R04095 RC00246 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_813571_1 1122137.AQXF01000003_gene1881 1.07e-87 265.0 COG0057@1|root,COG0057@2|Bacteria,1MU93@1224|Proteobacteria,2TR6E@28211|Alphaproteobacteria 28211|Alphaproteobacteria G Belongs to the glyceraldehyde-3-phosphate dehydrogenase family gapA GO:0000166,GO:0003674,GO:0003824,GO:0004365,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0036094,GO:0043891,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0097159,GO:1901265,GO:1901363 1.2.1.12 ko:K00134 ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01061 RC00149 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - Gp_dh_C,Gp_dh_N k59_813571_2 1122970.AUHC01000001_gene342 6.67e-10 59.3 COG0021@1|root,COG0021@2|Bacteria,1MUEY@1224|Proteobacteria,2TQUX@28211|Alphaproteobacteria,2K0UZ@204457|Sphingomonadales 204457|Sphingomonadales G Belongs to the transketolase family tktA - 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 - - - Transket_pyr,Transketolase_C,Transketolase_N k59_1493345_1 448385.sce6585 0.000185 49.3 COG1807@1|root,COG1807@2|Bacteria 2|Bacteria M 4-amino-4-deoxy-L-arabinose transferase activity - - - - - - - - - - - - PMT_2 k59_981999_1 926569.ANT_04690 7.05e-42 146.0 COG1079@1|root,COG1079@2|Bacteria,2G6CY@200795|Chloroflexi 200795|Chloroflexi S Branched-chain amino acid transport system / permease component - - - ko:K02057 - M00221 - - ko00000,ko00002,ko02000 3.A.1.2 - - BPD_transp_2 k59_981999_2 926569.ANT_04700 5.05e-27 107.0 COG4603@1|root,COG4603@2|Bacteria,2G686@200795|Chloroflexi 200795|Chloroflexi S Branched-chain amino acid transport system / permease component - - - ko:K02057 - M00221 - - ko00000,ko00002,ko02000 3.A.1.2 - - BPD_transp_2 k59_1493346_1 1229909.NSED_02240 1.27e-109 318.0 COG1097@1|root,arCOG00678@2157|Archaea,41SHV@651137|Thaumarchaeota 651137|Thaumarchaeota J Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome rrp4 - - ko:K03679 ko03018,map03018 M00390,M00391 - - ko00000,ko00001,ko00002,ko03019 - - - KH_1 k59_1549615_1 382464.ABSI01000012_gene2198 4.24e-17 84.0 COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria 2|Bacteria S cAMP biosynthetic process - - - - - - - - - - - - BTAD,TPR_11,TPR_16,TPR_7,TPR_8,Trans_reg_C k59_306871_1 1056820.KB900699_gene1243 7.06e-81 250.0 COG0739@1|root,COG0739@2|Bacteria,1MY2X@1224|Proteobacteria,1RMYN@1236|Gammaproteobacteria,2PNDW@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria M Peptidase family M23 - - - - - - - - - - - - Peptidase_M23 k59_1210020_1 1123037.AUDE01000062_gene2236 7.58e-66 221.0 COG1572@1|root,COG1572@2|Bacteria,4PMQR@976|Bacteroidetes,1IK7W@117743|Flavobacteriia 976|Bacteroidetes M C-terminal domain of CHU protein family - - - - - - - - - - - - CHU_C k59_1041805_1 301.JNHE01000011_gene3617 1.56e-31 129.0 COG0768@1|root,COG0768@2|Bacteria,1MV8C@1224|Proteobacteria,1RN9H@1236|Gammaproteobacteria,1YDZG@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria M Catalyzes cross-linking of the peptidoglycan cell wall mrdA GO:0000270,GO:0003674,GO:0003824,GO:0004180,GO:0004185,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006022,GO:0006023,GO:0006024,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0008238,GO:0008360,GO:0008658,GO:0009002,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016021,GO:0016043,GO:0016787,GO:0017171,GO:0019538,GO:0022603,GO:0022604,GO:0030203,GO:0031224,GO:0031226,GO:0031406,GO:0033218,GO:0033293,GO:0034645,GO:0036094,GO:0042221,GO:0042493,GO:0042546,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044425,GO:0044459,GO:0044464,GO:0045229,GO:0046677,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051128,GO:0065007,GO:0065008,GO:0070008,GO:0070011,GO:0070589,GO:0071554,GO:0071555,GO:0071704,GO:0071840,GO:0071944,GO:0071972,GO:0097159,GO:0140096,GO:1901135,GO:1901137,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901681 3.4.16.4 ko:K05515 ko00550,ko01501,map00550,map01501 - - - ko00000,ko00001,ko01000,ko01011 - - iEcE24377_1341.EcE24377A_0661,iPC815.YPO2604 PBP_dimer,Transpeptidase k59_1322202_2 671143.DAMO_1264 3.67e-70 236.0 COG1629@1|root,COG4771@2|Bacteria 2|Bacteria P TonB-dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_1153119_1 316407.1651257 9.77e-156 441.0 COG0320@1|root,COG0320@2|Bacteria,1MVRD@1224|Proteobacteria,1RMAT@1236|Gammaproteobacteria,3XP60@561|Escherichia 1236|Gammaproteobacteria H Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives lipA GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009106,GO:0009107,GO:0009108,GO:0009249,GO:0009987,GO:0010467,GO:0016053,GO:0016740,GO:0016782,GO:0016783,GO:0016992,GO:0018065,GO:0018130,GO:0018193,GO:0018205,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0051604,GO:0070283,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901576 2.8.1.8 ko:K03644 ko00785,ko01100,map00785,map01100 - R07767,R07768 RC01978 ko00000,ko00001,ko01000 - - iAPECO1_1312.APECO1_1427,iB21_1397.B21_00586,iBWG_1329.BWG_0499,iE2348C_1286.E2348C_0528,iEC55989_1330.EC55989_0620,iECABU_c1320.ECABU_c06820,iECBD_1354.ECBD_3023,iECB_1328.ECB_00597,iECDH10B_1368.ECDH10B_0589,iECDH1ME8569_1439.ECDH1ME8569_0597,iECD_1391.ECD_00597,iECED1_1282.ECED1_0624,iECH74115_1262.ECH74115_0716,iECIAI1_1343.ECIAI1_0611,iECIAI39_1322.ECIAI39_0603,iECNA114_1301.ECNA114_0567,iECO103_1326.ECO103_0635,iECO111_1330.ECO111_0658,iECO26_1355.ECO26_0702,iECOK1_1307.ECOK1_0638,iECP_1309.ECP_0658,iECS88_1305.ECS88_0669,iECSE_1348.ECSE_0695,iECSF_1327.ECSF_0567,iECSP_1301.ECSP_0681,iECUMN_1333.ECUMN_0720,iECW_1372.ECW_m0682,iECs_1301.ECs0666,iEKO11_1354.EKO11_3238,iETEC_1333.ETEC_0656,iEcDH1_1363.EcDH1_2998,iEcE24377_1341.EcE24377A_0652,iEcHS_1320.EcHS_A0679,iEcSMS35_1347.EcSMS35_0648,iEcolC_1368.EcolC_3017,iG2583_1286.G2583_0791,iJO1366.b0628,iLF82_1304.LF82_1199,iNRG857_1313.NRG857_02855,iSBO_1134.SBO_0492,iSDY_1059.SDY_0550,iSF_1195.SF0653,iSFxv_1172.SFxv_0720,iSSON_1240.SSON_0582,iS_1188.S0675,iSbBS512_1146.SbBS512_E0542,iUMN146_1321.UM146_14375,iUMNK88_1353.UMNK88_663,iUTI89_1310.UTI89_C0631,iWFL_1372.ECW_m0682,iY75_1357.Y75_RS03275,ic_1306.c0718 LIAS_N,Radical_SAM k59_136831_1 436308.Nmar_0385 1.72e-93 275.0 COG0080@1|root,arCOG04372@2157|Archaea,41SJW@651137|Thaumarchaeota 651137|Thaumarchaeota J Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors rpl11 - - ko:K02867 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L11,Ribosomal_L11_N k59_136831_2 1229909.NSED_01850 3.17e-62 193.0 COG1522@1|root,arCOG01580@2157|Archaea,41SJD@651137|Thaumarchaeota 651137|Thaumarchaeota K helix_turn_helix ASNC type - - - ko:K03718 - - - - ko00000,ko03000 - - - AsnC_trans_reg,HTH_24 k59_1605830_1 436308.Nmar_0715 4.22e-51 166.0 COG1310@1|root,arCOG01139@2157|Archaea,41SQ7@651137|Thaumarchaeota 651137|Thaumarchaeota S metal-dependent protease of the PAD1 JAB1 superfamily - - - - - - - - - - - - Prok-JAB k59_1493373_1 436308.Nmar_0842 1.94e-164 467.0 COG2141@1|root,arCOG02410@2157|Archaea,41SC0@651137|Thaumarchaeota 651137|Thaumarchaeota C Luciferase-like monooxygenase - - - - - - - - - - - - Bac_luciferase k59_1493373_2 1229909.NSED_04630 8.47e-31 118.0 COG0183@1|root,arCOG01278@2157|Archaea,41SB7@651137|Thaumarchaeota 651137|Thaumarchaeota I Thiolase, N-terminal domain - - 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N k59_1264877_1 1144313.PMI10_02845 4.74e-39 147.0 COG0823@1|root,COG0823@2|Bacteria,4PHEF@976|Bacteroidetes,1I8WH@117743|Flavobacteriia,2NZ9X@237|Flavobacterium 976|Bacteroidetes U Involved in the tonB-independent uptake of proteins - - - - - - - - - - - - - k59_1210037_1 400668.Mmwyl1_2277 3.53e-91 282.0 COG3288@1|root,COG3288@2|Bacteria,1MVXU@1224|Proteobacteria,1RN23@1236|Gammaproteobacteria,1XIDN@135619|Oceanospirillales 135619|Oceanospirillales C The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane pntA - 1.6.1.2 ko:K00324 ko00760,ko01100,map00760,map01100 - R00112 RC00001 ko00000,ko00001,ko01000 - - - AlaDh_PNT_C,AlaDh_PNT_N,PNTB_4TM k59_756726_1 1121035.AUCH01000017_gene2301 2.05e-05 45.4 COG0264@1|root,COG0264@2|Bacteria,1MUS2@1224|Proteobacteria,2VHSG@28216|Betaproteobacteria,2KU95@206389|Rhodocyclales 206389|Rhodocyclales J Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome tsf - - ko:K02357 - - - - ko00000,ko03012,ko03029 - - - EF_TS k59_756726_2 305700.B447_05228 3.6e-58 187.0 COG0052@1|root,COG0052@2|Bacteria,1MU33@1224|Proteobacteria,2VI8V@28216|Betaproteobacteria,2KUV5@206389|Rhodocyclales 206389|Rhodocyclales J Belongs to the universal ribosomal protein uS2 family rpsB - - ko:K02967 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S2 k59_81260_2 671143.DAMO_2792 6.3e-07 51.2 COG0701@1|root,COG0701@2|Bacteria,2NQ4Q@2323|unclassified Bacteria 2|Bacteria S Predicted permease MA20_06590 - - ko:K07089 - - - - ko00000 - - - ArsP_1 k59_306899_1 768671.ThimaDRAFT_2541 3.33e-46 156.0 COG3167@1|root,COG3167@2|Bacteria,1RBGW@1224|Proteobacteria,1S3XQ@1236|Gammaproteobacteria,1WXKR@135613|Chromatiales 135613|Chromatiales NU Pilus assembly protein PilO - - - ko:K02664 - - - - ko00000,ko02035,ko02044 - - - PilO k59_306899_2 765912.Thimo_0084 2.59e-27 107.0 COG3166@1|root,COG3166@2|Bacteria,1RF1S@1224|Proteobacteria,1S3S0@1236|Gammaproteobacteria,1WY4Z@135613|Chromatiales 135613|Chromatiales NU PFAM Fimbrial assembly - - - ko:K02663 - - - - ko00000,ko02035,ko02044 - - - PilN k59_756730_2 1415754.JQMK01000010_gene1449 3.94e-37 129.0 COG3070@1|root,COG3070@2|Bacteria,1RDWD@1224|Proteobacteria,1S496@1236|Gammaproteobacteria,46B8C@72275|Alteromonadaceae 1236|Gammaproteobacteria K TfoX N-terminal domain sxy GO:0006355,GO:0006810,GO:0007154,GO:0008150,GO:0009290,GO:0009292,GO:0009294,GO:0009605,GO:0009889,GO:0009987,GO:0009991,GO:0010468,GO:0010556,GO:0015931,GO:0019219,GO:0019222,GO:0030420,GO:0031323,GO:0031326,GO:0031344,GO:0031346,GO:0031668,GO:0044087,GO:0044089,GO:0044093,GO:0044764,GO:0048518,GO:0048522,GO:0050657,GO:0050789,GO:0050794,GO:0050896,GO:0051027,GO:0051090,GO:0051091,GO:0051128,GO:0051130,GO:0051171,GO:0051179,GO:0051234,GO:0051252,GO:0051704,GO:0051716,GO:0060255,GO:0060491,GO:0065007,GO:0065009,GO:0071496,GO:0071702,GO:0071705,GO:0080090,GO:0098657,GO:1903506,GO:1903656,GO:1903658,GO:2000112,GO:2001141 - ko:K07343 - - - - ko00000 - - - TfoX_C,TfoX_N k59_1041834_1 1122137.AQXF01000003_gene1909 2.05e-87 261.0 COG0041@1|root,COG0041@2|Bacteria,1RCWJ@1224|Proteobacteria,2U58D@28211|Alphaproteobacteria 28211|Alphaproteobacteria F Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) purE - 5.4.99.18 ko:K01588 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R07405 RC01947 ko00000,ko00001,ko00002,ko01000 - - - AIRC k59_1041834_2 358681.BBR47_05380 2.71e-06 48.5 COG0026@1|root,COG0026@2|Bacteria,1TQCD@1239|Firmicutes,4H9M5@91061|Bacilli,26REQ@186822|Paenibacillaceae 91061|Bacilli F Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) purK GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 6.3.4.18 ko:K01589 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R07404 RC01927 ko00000,ko00001,ko00002,ko01000 - - - 2-Hacid_dh_C,ATP-grasp k59_1493382_1 1304885.AUEY01000054_gene181 4.48e-11 63.9 COG0438@1|root,COG1216@1|root,COG2227@1|root,COG5325@1|root,COG0438@2|Bacteria,COG1216@2|Bacteria,COG2227@2|Bacteria,COG5325@2|Bacteria,1MVIM@1224|Proteobacteria,42QA0@68525|delta/epsilon subdivisions,2WJCD@28221|Deltaproteobacteria,2MIQN@213118|Desulfobacterales 28221|Deltaproteobacteria HMU Glycosyltransferase like family - - - ko:K20444 - - - - ko00000,ko01000,ko01005,ko02000 4.D.1.3 GT2,GT4 - Glyco_trans_1_4,Glycos_transf_2,Methyltransf_23 k59_1211247_1 1197477.IA57_06825 1.67e-37 133.0 COG2177@1|root,COG2177@2|Bacteria,4NH05@976|Bacteroidetes,1HXFX@117743|Flavobacteriia 976|Bacteroidetes D Required for cell division and gliding motility ftsX GO:0005575,GO:0005618,GO:0005623,GO:0006928,GO:0008150,GO:0009274,GO:0009276,GO:0009605,GO:0009607,GO:0009615,GO:0009987,GO:0030312,GO:0030313,GO:0031975,GO:0040011,GO:0043207,GO:0044464,GO:0048870,GO:0050896,GO:0051179,GO:0051301,GO:0051674,GO:0051704,GO:0051707,GO:0071944,GO:0071976 - ko:K09811 ko02010,map02010 M00256 - - ko00000,ko00001,ko00002,ko02000,ko03036 3.A.1.140 - - FtsX k59_1719749_1 998088.B565_0536 1.13e-91 273.0 COG1573@1|root,COG1573@2|Bacteria,1R9XV@1224|Proteobacteria,1S20R@1236|Gammaproteobacteria,1Y4AU@135624|Aeromonadales 135624|Aeromonadales L Uracil DNA glycosylase superfamily - - - - - - - - - - - - UDG k59_1719755_1 648757.Rvan_3132 9.5e-79 244.0 COG0596@1|root,COG0596@2|Bacteria,1MWW8@1224|Proteobacteria,2TS53@28211|Alphaproteobacteria,3N7J7@45401|Hyphomicrobiaceae 28211|Alphaproteobacteria E Belongs to the peptidase S33 family pip - 3.4.11.5 ko:K01259 ko00330,map00330 - R00135 - ko00000,ko00001,ko01000,ko01002 - - - Abhydrolase_1 k59_137982_1 436308.Nmar_1386 3.24e-187 526.0 COG0468@1|root,arCOG00415@2157|Archaea,41SBA@651137|Thaumarchaeota 651137|Thaumarchaeota L Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules radA - - ko:K04483 - - - - ko00000,ko03400 - - - HHH_5,Rad51 k59_644749_1 1122135.KB893135_gene982 2.24e-22 97.1 COG3528@1|root,COG3528@2|Bacteria,1R601@1224|Proteobacteria,2U1IH@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Protein conserved in bacteria - - - - - - - - - - - - DUF2219 k59_250327_1 365044.Pnap_1708 6.46e-10 60.8 COG3146@1|root,COG3146@2|Bacteria,1MU35@1224|Proteobacteria,2VH0Z@28216|Betaproteobacteria,4AAXS@80864|Comamonadaceae 28216|Betaproteobacteria S Peptidogalycan biosysnthesis/recognition - - - ko:K09919 - - - - ko00000 - - - FemAB_like k59_250327_2 545264.KB898745_gene1361 1.12e-68 219.0 COG0492@1|root,COG0492@2|Bacteria,1MV15@1224|Proteobacteria,1RMEX@1236|Gammaproteobacteria,1WWPK@135613|Chromatiales 135613|Chromatiales C Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family - - 1.8.1.9 ko:K00384 ko00450,map00450 - R02016,R03596,R09372 RC00013,RC02518,RC02873 ko00000,ko00001,ko01000 - - - Pyr_redox_2 k59_82426_1 686340.Metal_2275 6.47e-87 268.0 COG0004@1|root,COG0004@2|Bacteria,1NR9F@1224|Proteobacteria,1RNKF@1236|Gammaproteobacteria,1XEUM@135618|Methylococcales 135618|Methylococcales P PFAM Ammonium Transporter - - - ko:K03320 - - - - ko00000,ko02000 1.A.11 - - Ammonium_transp k59_814302_1 105559.Nwat_0990 4.21e-67 214.0 COG0500@1|root,COG2226@2|Bacteria,1PA5F@1224|Proteobacteria,1RY7A@1236|Gammaproteobacteria,1WW45@135613|Chromatiales 135613|Chromatiales H Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway bioC - 2.1.1.197 ko:K02169 ko00780,ko01100,map00780,map01100 M00572 R09543 RC00003,RC00460 ko00000,ko00001,ko00002,ko01000 - - - Methyltransf_11 k59_814302_2 269799.Gmet_0843 1.8e-05 47.0 COG0596@1|root,COG0596@2|Bacteria,1QXP7@1224|Proteobacteria,42SIW@68525|delta/epsilon subdivisions,2WPXC@28221|Deltaproteobacteria,43UZK@69541|Desulfuromonadales 28221|Deltaproteobacteria S PFAM alpha beta hydrolase fold bioH - 3.1.1.85 ko:K02170 ko00780,ko01100,map00780,map01100 M00572 R09725 RC00460,RC00461 ko00000,ko00001,ko00002,ko01000 - - - Abhydrolase_1 k59_308024_1 986075.CathTA2_0735 3.9e-123 361.0 COG0057@1|root,COG0057@2|Bacteria,1TNYU@1239|Firmicutes,4H9NS@91061|Bacilli 91061|Bacilli G Belongs to the glyceraldehyde-3-phosphate dehydrogenase family gapA GO:0000166,GO:0003674,GO:0003824,GO:0004365,GO:0005488,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016052,GO:0016053,GO:0016310,GO:0016491,GO:0016620,GO:0016903,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0036094,GO:0042866,GO:0043436,GO:0043891,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0051287,GO:0055086,GO:0055114,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:1901135,GO:1901137,GO:1901265,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901575,GO:1901576 1.2.1.12 ko:K00134 ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01061 RC00149 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - Gp_dh_C,Gp_dh_N k59_1774044_1 1144307.PMI04_01665 1.33e-30 114.0 COG3909@1|root,COG3909@2|Bacteria,1Q594@1224|Proteobacteria,2UG98@28211|Alphaproteobacteria,2K6Z1@204457|Sphingomonadales 204457|Sphingomonadales C Cytochrome C' - - - - - - - - - - - - Cytochrom_C_2 k59_1435452_1 220664.PFL_0831 7.01e-103 328.0 COG0458@1|root,COG0458@2|Bacteria,1MUDZ@1224|Proteobacteria,1RPIU@1236|Gammaproteobacteria,1YP5N@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria F Carbamoyl-phosphate synthetase ammonia chain carB GO:0000050,GO:0000166,GO:0003674,GO:0003824,GO:0004087,GO:0004088,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005951,GO:0006082,GO:0006139,GO:0006206,GO:0006220,GO:0006221,GO:0006520,GO:0006525,GO:0006526,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016053,GO:0016597,GO:0016874,GO:0016879,GO:0016884,GO:0017076,GO:0018130,GO:0019438,GO:0019627,GO:0019637,GO:0019693,GO:0019752,GO:0019856,GO:0030554,GO:0031406,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046112,GO:0046390,GO:0046394,GO:0046483,GO:0046872,GO:0055086,GO:0071704,GO:0071941,GO:0072527,GO:0072528,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494 6.3.5.5 ko:K01955 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - iAF1260.b0033,iBWG_1329.BWG_0031,iECDH10B_1368.ECDH10B_0034,iECDH1ME8569_1439.ECDH1ME8569_0031,iECUMN_1333.ECUMN_0034,iEcDH1_1363.EcDH1_3566,iJN746.PP_4723,iJO1366.b0033,iJR904.b0033,iPC815.YPO0482,iY75_1357.Y75_RS00170,iYL1228.KPN_00041 CPSase_L_D2,CPSase_L_D3,MGS k59_1096972_1 589873.EP13_14510 1.45e-37 137.0 COG2355@1|root,COG2355@2|Bacteria,1MWEW@1224|Proteobacteria,1RQGU@1236|Gammaproteobacteria,465Y7@72275|Alteromonadaceae 1236|Gammaproteobacteria E Zn-dependent dipeptidase, microsomal dipeptidase acdP - 3.4.13.19 ko:K01273 - - - - ko00000,ko00537,ko01000,ko01002,ko04147 - - - Peptidase_M19 k59_702833_1 35720.XP_003653924.1 1.15e-26 105.0 2ED7G@1|root,2SIX4@2759|Eukaryota,39RSJ@33154|Opisthokonta,3P17C@4751|Fungi,3QP9M@4890|Ascomycota,214WI@147550|Sordariomycetes,3U5WE@5139|Sordariales,3HAKD@35718|Chaetomiaceae 4751|Fungi S SnoaL-like domain - - - - - - - - - - - - SnoaL_4 k59_702833_2 1545915.JROG01000004_gene1729 3.87e-31 122.0 COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,2TR6Q@28211|Alphaproteobacteria,2K0U4@204457|Sphingomonadales 204457|Sphingomonadales L DEAD DEAH box helicase - - 3.6.4.13 ko:K11927 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - DEAD,Helicase_C k59_1265683_1 391587.KAOT1_18802 4.25e-165 474.0 COG1696@1|root,COG1696@2|Bacteria,4NFK5@976|Bacteroidetes,1HWM1@117743|Flavobacteriia 976|Bacteroidetes M Membrane protein involved in D-alanine export - - - - - - - - - - - - MBOAT k59_475102_1 998674.ATTE01000001_gene2523 4.93e-67 218.0 COG1726@1|root,COG1726@2|Bacteria,1MU36@1224|Proteobacteria,1RPU1@1236|Gammaproteobacteria,460CI@72273|Thiotrichales 72273|Thiotrichales C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol nqrA - 1.6.5.8 ko:K00346 - - - - ko00000,ko01000 - - - NQRA,NQRA_SLBB k59_82440_3 436308.Nmar_1483 6.9e-54 175.0 arCOG08638@1|root,arCOG08638@2157|Archaea,41T08@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_250347_1 1279017.AQYJ01000025_gene584 1.96e-128 380.0 COG0644@1|root,COG2440@1|root,COG0644@2|Bacteria,COG2440@2|Bacteria,1MVU6@1224|Proteobacteria,1RNY5@1236|Gammaproteobacteria,464BX@72275|Alteromonadaceae 1236|Gammaproteobacteria C Electron transfer flavoprotein-ubiquinone oxidoreductase etfD - 1.5.5.1 ko:K00311 - - - - ko00000,ko01000 - - - ETF_QO,FAD_binding_2,NAD_binding_8,Thi4 k59_1042998_1 640511.BC1002_2247 6.8e-37 137.0 COG1894@1|root,COG1894@2|Bacteria,1MV8F@1224|Proteobacteria,2VIGR@28216|Betaproteobacteria,1K3B8@119060|Burkholderiaceae 28216|Betaproteobacteria C PFAM Respiratory-chain NADH dehydrogenase domain 51 kDa subunit fdsB - - ko:K00124 ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200 - R00519 RC02796 ko00000,ko00001 - - - Complex1_51K,NADH_4Fe-4S,SLBB k59_1042998_2 195105.CN97_18130 6.7e-41 140.0 COG1905@1|root,COG1905@2|Bacteria,1RHBU@1224|Proteobacteria,2U72T@28211|Alphaproteobacteria 28211|Alphaproteobacteria C PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit fdsG - - ko:K00127 ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200 - R00519 RC02796 ko00000,ko00001 - - - 2Fe-2S_thioredx k59_138012_1 31234.CRE18143 1.82e-24 107.0 COG2801@1|root,KOG0017@2759|Eukaryota,38F42@33154|Opisthokonta,3BA5H@33208|Metazoa,3E5BZ@33213|Bilateria,40RH1@6231|Nematoda,1M8M8@119089|Chromadorea,4179I@6236|Rhabditida 33208|Metazoa L Integrase core domain - - - - - - - - - - - - Asp_protease_2,Chromo,Glycoprotein_B,RVT_1,Retrotrans_gag,gag-asp_proteas,rve k59_644767_1 999541.bgla_2g29420 1.18e-81 255.0 COG0624@1|root,COG0624@2|Bacteria,1MVUX@1224|Proteobacteria,2VHQ8@28216|Betaproteobacteria,1K0H7@119060|Burkholderiaceae 28216|Betaproteobacteria E Amidase, hydantoinase carbamoylase family - - 3.5.1.6,3.5.1.87 ko:K06016 ko00240,ko01100,map00240,map01100 M00046 R00905,R04666 RC00096 ko00000,ko00001,ko00002,ko01000 - - - M20_dimer,Peptidase_M20,Peptidase_M28 k59_589581_1 935261.JAGL01000036_gene3198 2.14e-20 93.2 COG3836@1|root,COG3836@2|Bacteria,1MUSG@1224|Proteobacteria,2TT2W@28211|Alphaproteobacteria,43JQZ@69277|Phyllobacteriaceae 28211|Alphaproteobacteria G Belongs to the HpcH HpaI aldolase family hpcH - 4.1.2.20,4.1.2.52 ko:K01630,ko:K02510 ko00053,ko00350,ko01120,map00053,map00350,map01120 - R01645,R01647,R02754,R03277 RC00307,RC00435,RC00572,RC00574,RC03057 ko00000,ko00001,ko01000 - - - HpcH_HpaI k59_475110_1 443144.GM21_2330 3.41e-63 208.0 COG0436@1|root,COG0436@2|Bacteria,1QW10@1224|Proteobacteria,42MQA@68525|delta/epsilon subdivisions,2WJDK@28221|Deltaproteobacteria,43S5R@69541|Desulfuromonadales 28221|Deltaproteobacteria E Aminotransferase class I and II bamJ - - - - - - - - - - - Aminotran_1_2 k59_138023_1 518766.Rmar_1751 1.22e-38 147.0 COG3118@1|root,COG3118@2|Bacteria,4PND9@976|Bacteroidetes 976|Bacteroidetes O ASPIC and UnbV - - - - - - - - - - - - UnbV_ASPIC,VCBS k59_193391_1 225937.HP15_1351 1.59e-38 139.0 COG0842@1|root,COG0842@2|Bacteria,1MW5R@1224|Proteobacteria,1RPB4@1236|Gammaproteobacteria,4655S@72275|Alteromonadaceae 1236|Gammaproteobacteria V ABC-2 family transporter protein ybhS - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_3 k59_193391_2 1117319.PSPO_04312 1.25e-23 92.4 COG3671@1|root,COG3671@2|Bacteria,1MZMW@1224|Proteobacteria,1S8EV@1236|Gammaproteobacteria,2Q3P1@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria S membrane - - - - - - - - - - - - DUF4870 k59_364854_1 158500.BV97_03918 6.51e-103 307.0 COG0330@1|root,COG0330@2|Bacteria,1P8ZI@1224|Proteobacteria,2TTBE@28211|Alphaproteobacteria,2JZUP@204457|Sphingomonadales 204457|Sphingomonadales O COG0330 Membrane protease subunits, stomatin prohibitin homologs - - - - - - - - - - - - Band_7 k59_1381342_1 1229909.NSED_08725 2.96e-67 210.0 COG1985@1|root,arCOG01484@2157|Archaea,41SK2@651137|Thaumarchaeota 651137|Thaumarchaeota H RibD C-terminal domain - - 1.1.1.302 ko:K14654 ko00740,ko01100,map00740,map01100 - R09375,R09376 RC00933 ko00000,ko00001,ko01000 - - - RibD_C k59_589601_1 1121439.dsat_0775 3.15e-57 201.0 COG2208@1|root,COG2770@1|root,COG2208@2|Bacteria,COG2770@2|Bacteria,1MXJQ@1224|Proteobacteria,42MFQ@68525|delta/epsilon subdivisions,2WIJ4@28221|Deltaproteobacteria,2M7Z5@213115|Desulfovibrionales 28221|Deltaproteobacteria KT SMART protein phosphatase 2C domain protein - - 3.1.3.3 ko:K07315 - - - - ko00000,ko01000,ko03021 - - - Cache_3-Cache_2,HAMP,SpoIIE,dCache_1,dCache_2 k59_138036_1 517722.AEUE01000001_gene2674 1.06e-33 127.0 COG2159@1|root,COG2159@2|Bacteria,1MVTS@1224|Proteobacteria,2VGQX@28211|Alphaproteobacteria,2KE5I@204457|Sphingomonadales 204457|Sphingomonadales S Amidohydrolase - - - - - - - - - - - - Amidohydro_2 k59_138036_2 1234595.C725_1869 1.06e-54 187.0 COG2211@1|root,COG2211@2|Bacteria,1MVUM@1224|Proteobacteria,2TVI8@28211|Alphaproteobacteria 28211|Alphaproteobacteria G COG2211 Na melibiose symporter and related transporters - - - - - - - - - - - - MFS_2 k59_1494633_1 330214.NIDE2745 5.8e-73 233.0 COG0373@1|root,COG0373@2|Bacteria,3J0BD@40117|Nitrospirae 40117|Nitrospirae H Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) hemA - 1.2.1.70 ko:K02492 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R04109 RC00055,RC00149 ko00000,ko00001,ko00002,ko01000 - - - GlutR_N,GlutR_dimer,Shikimate_DH k59_1662655_1 330214.NIDE1382 8.01e-44 156.0 COG2223@1|root,COG2223@2|Bacteria,3J0YQ@40117|Nitrospirae 40117|Nitrospirae P Major Facilitator Superfamily - - - ko:K02575 ko00910,map00910 M00615 - - ko00000,ko00001,ko00002,ko02000 2.A.1.8 - - MFS_1 k59_702880_1 316407.1799590 2.43e-120 352.0 COG0247@1|root,COG0247@2|Bacteria,1MWTK@1224|Proteobacteria,1RQ9M@1236|Gammaproteobacteria,3XP8B@561|Escherichia 1236|Gammaproteobacteria C Anaerobic glycerol-3-phosphate dehydrogenase subunit C glpC GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0008150,GO:0008152,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0022900,GO:0043167,GO:0043169,GO:0044237,GO:0044464,GO:0045333,GO:0046872,GO:0048037,GO:0051536,GO:0051540,GO:0055114,GO:0071944 1.1.5.3 ko:K00113,ko:K11473 ko00564,ko00630,ko01100,ko01110,ko01120,ko01130,map00564,map00630,map01100,map01110,map01120,map01130 - R00475,R00848 RC00029,RC00042 ko00000,ko00001,ko01000 - - - CCG,Fer4_8 k59_1551015_1 1178482.BJB45_03365 3.47e-172 487.0 COG0039@1|root,COG0039@2|Bacteria,1MV57@1224|Proteobacteria,1RMAX@1236|Gammaproteobacteria,1XIPA@135619|Oceanospirillales 135619|Oceanospirillales C Catalyzes the reversible oxidation of malate to oxaloacetate mdh - 1.1.1.37 ko:K00024 ko00020,ko00270,ko00620,ko00630,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00270,map00620,map00630,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740 R00342,R07136 RC00031 ko00000,ko00001,ko00002,ko01000 - - - Ldh_1_C,Ldh_1_N k59_82493_2 1248916.ANFY01000015_gene75 1.16e-25 105.0 COG1680@1|root,COG1680@2|Bacteria,1QD0J@1224|Proteobacteria,2U189@28211|Alphaproteobacteria,2K4PZ@204457|Sphingomonadales 204457|Sphingomonadales V beta-lactamase - - - - - - - - - - - - Beta-lactamase k59_1719835_1 1121918.ARWE01000001_gene1887 7.31e-55 185.0 COG1508@1|root,COG1508@2|Bacteria,1MW4V@1224|Proteobacteria,42M3C@68525|delta/epsilon subdivisions,2WJ21@28221|Deltaproteobacteria,43RYZ@69541|Desulfuromonadales 28221|Deltaproteobacteria K Sigma-54 factor, Activator interacting domain (AID) rpoN - - ko:K03092 ko02020,ko05111,map02020,map05111 - - - ko00000,ko00001,ko03021 - - - Sigma54_AID,Sigma54_CBD,Sigma54_DBD k59_25278_1 1123037.AUDE01000018_gene2927 1.07e-72 247.0 COG0642@1|root,COG0745@1|root,COG3292@1|root,COG0745@2|Bacteria,COG2205@2|Bacteria,COG3292@2|Bacteria,4NDXU@976|Bacteroidetes,1HXUN@117743|Flavobacteriia 976|Bacteroidetes T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - HATPase_c,HTH_18,HisKA,Reg_prop,Response_reg,Y_Y_Y k59_1381374_1 1265313.HRUBRA_01638 1.36e-89 277.0 COG2308@1|root,COG2308@2|Bacteria,1MUAD@1224|Proteobacteria,1RNAF@1236|Gammaproteobacteria,1J94R@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Circularly permuted ATP-grasp type 2 - - - - - - - - - - - - CP_ATPgrasp_2 k59_250408_1 565045.NOR51B_465 1.09e-118 363.0 COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,1RMZ8@1236|Gammaproteobacteria,1J7SB@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria I 3-hydroxyacyl-coa dehydrogenase fadJ - 1.1.1.35,4.2.1.17,5.1.2.3 ko:K01782 ko00071,ko00280,ko00281,ko00310,ko00362,ko00380,ko00410,ko00640,ko00650,ko00903,ko00930,ko01040,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00362,map00380,map00410,map00640,map00650,map00903,map00930,map01040,map01100,map01110,map01120,map01130,map01200,map01212 M00032,M00087 R01975,R03026,R03045,R03276,R04137,R04170,R04203,R04204,R04224,R04737,R04738,R04739,R04740,R04741,R04744,R04745,R04746,R04748,R04749,R05066,R05305,R06411,R06412,R06941,R06942,R07935,R07951,R08093,R08094 RC00029,RC00099,RC00117,RC00241,RC00525,RC00831,RC00834,RC00896,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 - - - 3HCDH,3HCDH_N,ECH_1 k59_318123_2 395494.Galf_0768 7.61e-12 63.2 COG2010@1|root,COG2010@2|Bacteria,1RG22@1224|Proteobacteria,2W8VP@28216|Betaproteobacteria,44WMU@713636|Nitrosomonadales 1224|Proteobacteria C PFAM cytochrome c class I - - - ko:K02305 ko00910,ko01120,map00910,map01120 M00529 R00294 RC02794 ko00000,ko00001,ko00002 3.D.4.10 - - Cytochrom_C k59_1391289_2 1499967.BAYZ01000197_gene3056 2.56e-95 288.0 28H88@1|root,2Z7K7@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - Phage_cap_E k59_318136_1 436308.Nmar_1737 2.04e-67 209.0 COG0431@1|root,arCOG04624@2157|Archaea,41T2F@651137|Thaumarchaeota 651137|Thaumarchaeota S NADPH-dependent FMN reductase - - - - - - - - - - - - FMN_red k59_1329881_1 1323663.AROI01000006_gene2830 1.29e-74 236.0 COG0006@1|root,COG0006@2|Bacteria,1MUZS@1224|Proteobacteria,1RN0W@1236|Gammaproteobacteria 1236|Gammaproteobacteria E aminopeptidase pepP - 3.4.11.9 ko:K01262 - - - - ko00000,ko01000,ko01002 - - - AMP_N,Peptidase_M24 k59_35036_1 1280950.HJO_05795 2.48e-59 201.0 COG3507@1|root,COG3507@2|Bacteria,1NNX4@1224|Proteobacteria,2U06C@28211|Alphaproteobacteria,43ZEC@69657|Hyphomonadaceae 28211|Alphaproteobacteria G Belongs to the glycosyl hydrolase 43 family - - 3.2.1.37,3.2.1.55 ko:K01198,ko:K01209 ko00520,ko01100,map00520,map01100 - R01433,R01762 RC00467 ko00000,ko00001,ko01000 - GH43,GH51 - Glyco_hydro_43 k59_35036_2 1121904.ARBP01000029_gene2139 8.78e-09 55.5 COG0823@1|root,COG0823@2|Bacteria,4NG4S@976|Bacteroidetes,47KMG@768503|Cytophagia 976|Bacteroidetes U WD40-like Beta Propeller Repeat - - - - - - - - - - - - PD40 k59_599502_1 1229909.NSED_01430 1.35e-99 302.0 COG0260@1|root,arCOG04322@2157|Archaea,41SYD@651137|Thaumarchaeota 651137|Thaumarchaeota E Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides pepA - 3.4.11.1 ko:K01255 ko00480,ko01100,map00480,map01100 - R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 - - - Peptidase_M17,Peptidase_M17_N k59_482071_1 1198232.CYCME_1952 4.73e-42 149.0 COG0598@1|root,COG0598@2|Bacteria,1MW8W@1224|Proteobacteria,1RRTZ@1236|Gammaproteobacteria,460RS@72273|Thiotrichales 72273|Thiotrichales P CorA-like Mg2+ transporter protein - - - ko:K16074 - - - - ko00000,ko02000 1.A.35.4 - - CorA k59_1391310_1 272134.KB731324_gene6630 3.38e-80 261.0 COG0405@1|root,COG0405@2|Bacteria,1G14N@1117|Cyanobacteria,1H83V@1150|Oscillatoriales 1117|Cyanobacteria E PFAM Gamma-glutamyltranspeptidase ggt - 2.3.2.2,3.4.19.13 ko:K00681 ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100 - R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935 RC00064,RC00090,RC00096 ko00000,ko00001,ko01000,ko01002 - - - G_glu_transpept k59_375925_1 1380394.JADL01000033_gene4100 9.3e-90 272.0 COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,2TQTP@28211|Alphaproteobacteria,2JS2T@204441|Rhodospirillales 204441|Rhodospirillales L Transposase IS116/IS110/IS902 family - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_1780938_1 436308.Nmar_1509 6.35e-180 511.0 COG0608@1|root,arCOG00427@2157|Archaea,41SZF@651137|Thaumarchaeota 651137|Thaumarchaeota L DHHA1 domain - - - ko:K07463 - - - - ko00000 - - - DHHA1 k59_1562901_1 997296.PB1_06797 1.97e-57 194.0 COG1066@1|root,COG1066@2|Bacteria,1TQ7Y@1239|Firmicutes,4H9YC@91061|Bacilli,1ZB8H@1386|Bacillus 91061|Bacilli O DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function radA - - ko:K04485 - - - - ko00000,ko03400 - - - AAA_25,ATPase,ChlI k59_319404_1 649638.Trad_1259 3.06e-135 394.0 COG0045@1|root,COG0045@2|Bacteria,1WIT1@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus C Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit sucC - 6.2.1.5 ko:K01903 ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374,M00620 R00405,R02404 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000 - - - ATP-grasp_2,Ligase_CoA k59_1670825_1 504487.JCM19302_902 6.77e-54 192.0 COG1361@1|root,COG3291@1|root,COG1361@2|Bacteria,COG3291@2|Bacteria,4NEWJ@976|Bacteroidetes,1HZA6@117743|Flavobacteriia 976|Bacteroidetes MU C-type lectin (CTL) or carbohydrate-recognition domain (CRD) - - - - - - - - - - - - CHU_C,PA14 k59_427496_2 479433.Caci_2850 4.98e-07 52.0 2B582@1|root,33M2S@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_1443748_1 1394178.AWOO02000026_gene5128 1.89e-48 166.0 COG1414@1|root,COG1414@2|Bacteria,2GKF4@201174|Actinobacteria 201174|Actinobacteria K transcriptional regulator - - - - - - - - - - - - HTH_IclR,IclR k59_482903_2 1123368.AUIS01000003_gene1608 9.3e-12 65.9 COG3271@1|root,COG3271@2|Bacteria,1RHAJ@1224|Proteobacteria,1S6IC@1236|Gammaproteobacteria,2ND8C@225057|Acidithiobacillales 225057|Acidithiobacillales S Peptidase C39 family - - - ko:K06992 - - - - ko00000 - - - Peptidase_C39 k59_823954_1 2340.JV46_19800 6.97e-72 225.0 COG1796@1|root,COG1796@2|Bacteria,1QF8Z@1224|Proteobacteria,1RRQ5@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Helix-hairpin-helix domain - - - ko:K04477 - - - - ko00000 - - - HHH_5,HHH_8 k59_319425_1 1303518.CCALI_01585 2.5e-65 224.0 COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria 2|Bacteria G General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) ppdK - 2.7.9.1 ko:K01006 ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200 M00169,M00171,M00172,M00173 R00206 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - PEP-utilizers,PEP-utilizers_C,PPDK_N k59_653019_1 316407.85676942 2.74e-133 380.0 COG1349@1|root,COG1349@2|Bacteria,1QM4U@1224|Proteobacteria,1RNN2@1236|Gammaproteobacteria,3XNF0@561|Escherichia 1236|Gammaproteobacteria K Represses ulaG and the ulaABCDEF operon ulaR GO:0003674,GO:0005488,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0019842,GO:0030246,GO:0031406,GO:0031418,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0048029,GO:0048037,GO:0050662,GO:0071704,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576 - ko:K03477 - - - - ko00000,ko03000 - - - DeoRC,HTH_DeoR k59_261235_1 1288826.MSNKSG1_00081 2.11e-15 79.0 COG3107@1|root,COG3107@2|Bacteria,1MUHR@1224|Proteobacteria,1RXX4@1236|Gammaproteobacteria,465I7@72275|Alteromonadaceae 1236|Gammaproteobacteria M (Lipo)protein lpoA GO:0000270,GO:0003674,GO:0005575,GO:0005623,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009279,GO:0009987,GO:0016020,GO:0019867,GO:0030203,GO:0030234,GO:0030312,GO:0030313,GO:0031241,GO:0031975,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044425,GO:0044462,GO:0044464,GO:0050790,GO:0065007,GO:0065009,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:0098552,GO:0098772,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 - ko:K07121 - - - - ko00000 - - - LppC k59_261235_2 485915.Dret_2019 3.06e-18 81.6 COG0792@1|root,COG0792@2|Bacteria,1N6VN@1224|Proteobacteria,42VES@68525|delta/epsilon subdivisions,2WRSC@28221|Deltaproteobacteria,2MCFG@213115|Desulfovibrionales 28221|Deltaproteobacteria L Belongs to the UPF0102 family - - - ko:K07460 - - - - ko00000 - - - UPF0102 k59_261235_3 498211.CJA_0925 1.67e-21 90.1 COG0279@1|root,COG0279@2|Bacteria,1NJ8X@1224|Proteobacteria,1RS1Y@1236|Gammaproteobacteria,1FFZW@10|Cellvibrio 1236|Gammaproteobacteria G SIS domain gmhA - 5.3.1.28 ko:K03271,ko:K12961 ko00540,ko01100,map00540,map01100 M00064 R05645,R09768,R09769 RC00434 ko00000,ko00001,ko00002,ko01000,ko01005,ko03036 - - - SIS_2 k59_1728733_1 595537.Varpa_3801 2.57e-25 97.4 COG0662@1|root,COG0662@2|Bacteria,1N1YZ@1224|Proteobacteria,2VU48@28216|Betaproteobacteria 28216|Betaproteobacteria G Cupin domain - - - - - - - - - - - - Cupin_2 k59_1728733_2 219305.MCAG_03243 9.47e-11 58.9 COG2350@1|root,COG2350@2|Bacteria,2IRZP@201174|Actinobacteria,4DFRU@85008|Micromonosporales 201174|Actinobacteria S Protein conserved in bacteria - - - - - - - - - - - - YCII k59_375956_1 1108849.XP_002557153.1 5.39e-07 58.5 COG2272@1|root,KOG1516@2759|Eukaryota,3A169@33154|Opisthokonta,3P217@4751|Fungi,3QU0E@4890|Ascomycota,20K6P@147545|Eurotiomycetes 4751|Fungi I Carboxylesterase family - - - - - - - - - - - - COesterase k59_1392574_1 317025.Tcr_2035 3.07e-08 57.0 COG0068@1|root,COG0068@2|Bacteria,1MVP8@1224|Proteobacteria,1RP08@1236|Gammaproteobacteria,45ZRI@72273|Thiotrichales 72273|Thiotrichales O Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide - - - ko:K04656 - - - - ko00000 - - - Acylphosphatase,Sua5_yciO_yrdC,zf-HYPF k59_1392574_2 269084.syc1560_d 7.18e-15 68.9 COG0298@1|root,COG0298@2|Bacteria,1G9FZ@1117|Cyanobacteria,1H1PR@1129|Synechococcus 1117|Cyanobacteria O HupF/HypC family hypC - - ko:K04653 - - - - ko00000 - - - HupF_HypC k59_1105260_1 886293.Sinac_7397 1.09e-145 427.0 COG1861@1|root,COG1861@2|Bacteria,2J3F7@203682|Planctomycetes 203682|Planctomycetes M PFAM Transposase DDE domain - - - - - - - - - - - - DDE_Tnp_1_4 k59_482920_2 203122.Sde_2529 1.78e-44 156.0 COG0823@1|root,COG0823@2|Bacteria,1MV09@1224|Proteobacteria,1RMCY@1236|Gammaproteobacteria,464D7@72275|Alteromonadaceae 1236|Gammaproteobacteria U Involved in the TonB-independent uptake of proteins tolB GO:0003674,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006810,GO:0008104,GO:0008150,GO:0009719,GO:0009987,GO:0010033,GO:0010243,GO:0015031,GO:0015833,GO:0015893,GO:0017038,GO:0019904,GO:0030288,GO:0030313,GO:0031975,GO:0032153,GO:0032991,GO:0033036,GO:0042221,GO:0042493,GO:0042597,GO:0042886,GO:0042891,GO:0043213,GO:0044464,GO:0044877,GO:0045184,GO:0046677,GO:0046678,GO:0050896,GO:0051179,GO:0051234,GO:0051716,GO:0070887,GO:0071236,GO:0071237,GO:0071310,GO:0071417,GO:0071495,GO:0071702,GO:0071705,GO:1901652,GO:1901653,GO:1901698,GO:1901699,GO:1901700,GO:1901701 - ko:K03641 - - - - ko00000,ko02000 2.C.1.2 - - PD40,TolB_N k59_990938_1 1122137.AQXF01000001_gene2776 2.82e-27 104.0 2BZV0@1|root,2Z7UQ@2|Bacteria,1QEAD@1224|Proteobacteria,2UQ8G@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_990938_2 551275.KB899546_gene1974 1.28e-64 208.0 2C57D@1|root,2Z7RS@2|Bacteria,1MX6G@1224|Proteobacteria,2TTDU@28211|Alphaproteobacteria,43WQ2@69657|Hyphomonadaceae 28211|Alphaproteobacteria S Protein of unknown function (DUF2891) - - - - - - - - - - - - DUF2891 k59_653035_1 1038860.AXAP01000031_gene5751 2.76e-10 59.7 COG0824@1|root,COG0824@2|Bacteria,1R6A6@1224|Proteobacteria,2TU6J@28211|Alphaproteobacteria,3JR33@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S Thioesterase - - - - - - - - - - - - - k59_1105261_1 436308.Nmar_1754 1.5e-81 256.0 COG0527@1|root,arCOG00861@2157|Archaea,41SFA@651137|Thaumarchaeota 651137|Thaumarchaeota E Belongs to the aspartokinase family - - 2.7.2.4 ko:K00928 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00017,M00018,M00033,M00525,M00526,M00527 R00480 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase,ACT_7 k59_319449_1 1348657.M622_14190 5.59e-39 141.0 COG0518@1|root,COG0519@1|root,COG0518@2|Bacteria,COG0519@2|Bacteria,1MU2A@1224|Proteobacteria,2VHNG@28216|Betaproteobacteria,2KVB1@206389|Rhodocyclales 206389|Rhodocyclales F Catalyzes the synthesis of GMP from XMP guaA - 6.3.5.2 ko:K01951 ko00230,ko00983,ko01100,map00230,map00983,map01100 M00050 R01230,R01231,R08244 RC00010,RC00204 ko00000,ko00001,ko00002,ko01000,ko01002 - - - GATase,GMP_synt_C,NAD_synthase k59_1392594_1 1122137.AQXF01000001_gene3185 5.03e-94 300.0 COG0249@1|root,COG0249@2|Bacteria,1MUGX@1224|Proteobacteria,2TQRR@28211|Alphaproteobacteria 28211|Alphaproteobacteria L that it carries out the mismatch recognition step. This protein has a weak ATPase activity mutS GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - ko:K03555 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V k59_92197_1 1173028.ANKO01000094_gene2611 1.54e-30 121.0 COG1680@1|root,COG1680@2|Bacteria,1G6GD@1117|Cyanobacteria,1HBFP@1150|Oscillatoriales 1117|Cyanobacteria V Beta-lactamase - - 3.4.16.4 ko:K01286 - - - - ko00000,ko01000 - - - Beta-lactamase k59_1562968_2 1449976.KALB_4306 1.02e-08 59.7 COG2197@1|root,COG2197@2|Bacteria,2GJG4@201174|Actinobacteria,4DYJ2@85010|Pseudonocardiales 201174|Actinobacteria K Response regulator receiver domain - - - - - - - - - - - - GerE,Response_reg k59_713911_1 1229909.NSED_08945 2.55e-73 249.0 COG4257@1|root,arCOG06267@1|root,arCOG03564@2157|Archaea,arCOG06267@2157|Archaea,41S5S@651137|Thaumarchaeota 651137|Thaumarchaeota V resistance protein - - - ko:K14166 - - - - ko00000,ko02000 - - - CopC,CopD k59_375995_1 926569.ANT_04950 6.58e-49 167.0 COG0183@1|root,COG0183@2|Bacteria,2G5YW@200795|Chloroflexi 200795|Chloroflexi I Belongs to the thiolase family - - - - - - - - - - - - Thiolase_C,Thiolase_N k59_538084_1 743721.Psesu_1789 2.33e-70 223.0 COG0604@1|root,COG0604@2|Bacteria,1MV3W@1224|Proteobacteria,1RMHG@1236|Gammaproteobacteria,1X33P@135614|Xanthomonadales 135614|Xanthomonadales C Quinone oxidoreductase - - - - - - - - - - - - ADH_N,ADH_zinc_N k59_376000_1 436308.Nmar_0089 1.9e-74 235.0 COG1599@1|root,arCOG01510@2157|Archaea,41S9M@651137|Thaumarchaeota 651137|Thaumarchaeota L COG1599 Single-stranded DNA-binding replication protein A (RPA), large (70 kD) subunit and related ssDNA-binding proteins - - - ko:K07466 ko03030,ko03420,ko03430,ko03440,ko03460,map03030,map03420,map03430,map03440,map03460 M00288 - - ko00000,ko00001,ko00002,ko03000,ko03032,ko03400 - - - - k59_376000_2 436308.Nmar_0088 1.11e-77 254.0 COG1201@1|root,arCOG00557@2157|Archaea,41S8P@651137|Thaumarchaeota 651137|Thaumarchaeota L DEAD/H associated - - - ko:K03724 - - - - ko00000,ko01000,ko03400 - - - DEAD,DEAD_assoc,Helicase_C k59_261294_1 1121935.AQXX01000054_gene2919 2.51e-75 230.0 COG1961@1|root,COG1961@2|Bacteria,1MXXT@1224|Proteobacteria,1S08N@1236|Gammaproteobacteria,1XMAS@135619|Oceanospirillales 135619|Oceanospirillales L Resolvase, N terminal domain - - - - - - - - - - - - HTH_7,Resolvase k59_1505661_1 436308.Nmar_0651 7.23e-35 132.0 COG1196@1|root,arCOG00371@2157|Archaea,41SDS@651137|Thaumarchaeota 651137|Thaumarchaeota D SMC proteins Flexible Hinge Domain - - - ko:K03529 - - - - ko00000,ko03036 - - - SMC_N,SMC_hinge k59_1505661_2 1229909.NSED_03360 4.95e-91 275.0 COG4608@1|root,arCOG00184@2157|Archaea,41S9E@651137|Thaumarchaeota 651137|Thaumarchaeota E Oligopeptide/dipeptide transporter, C-terminal region - - - ko:K02032 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - ABC_tran,oligo_HPY k59_1616192_1 42256.RradSPS_2920 9.63e-33 120.0 COG0590@1|root,COG0590@2|Bacteria,2I9KR@201174|Actinobacteria 201174|Actinobacteria FJ CMP dCMP deaminase, zinc-binding - - - - - - - - - - - - dCMP_cyt_deam_1 k59_1562999_1 411154.GFO_2368 1.94e-06 49.7 COG2318@1|root,COG2318@2|Bacteria,4NSE5@976|Bacteroidetes,1I4NU@117743|Flavobacteriia 976|Bacteroidetes S Damage-inducible protein DinB - - - - - - - - - - - - DinB k59_1562999_2 1120951.AUBG01000010_gene2079 3.44e-88 260.0 COG0720@1|root,COG0720@2|Bacteria,4NM8H@976|Bacteroidetes,1I173@117743|Flavobacteriia 976|Bacteroidetes H 6-pyruvoyl tetrahydropterin synthase queD - 4.1.2.50,4.2.3.12 ko:K01737 ko00790,ko01100,map00790,map01100 M00842,M00843 R04286,R09959 RC01117,RC02846,RC02847 ko00000,ko00001,ko00002,ko01000,ko03016 - - - PTPS k59_600863_1 1056820.KB900663_gene3846 1.43e-93 283.0 COG0012@1|root,COG0012@2|Bacteria,1MVM4@1224|Proteobacteria,1RMBI@1236|Gammaproteobacteria,2PN73@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria J Protein of unknown function (DUF933) ychF GO:0003674,GO:0003824,GO:0004857,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006950,GO:0006979,GO:0008150,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030234,GO:0043021,GO:0043022,GO:0043023,GO:0043086,GO:0044092,GO:0044424,GO:0044464,GO:0044877,GO:0050790,GO:0050896,GO:0065007,GO:0065009,GO:0098772 - ko:K06942 - - - - ko00000,ko03009 - - - MMR_HSR1,YchF-GTPase_C k59_1505662_1 1484460.JSWG01000015_gene1067 1.97e-72 231.0 COG2133@1|root,COG2133@2|Bacteria,4NF0B@976|Bacteroidetes,1HX9D@117743|Flavobacteriia 976|Bacteroidetes G Glucose / Sorbosone dehydrogenase - - - - - - - - - - - - CBM_6,GSDH k59_884426_1 377629.TERTU_1274 1.07e-63 203.0 COG1802@1|root,COG1802@2|Bacteria,1PFIA@1224|Proteobacteria,1RXBC@1236|Gammaproteobacteria,2PQKQ@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria K FCD - - - - - - - - - - - - FCD,GntR k59_600872_1 765914.ThisiDRAFT_1281 4.86e-119 358.0 COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,1RMBS@1236|Gammaproteobacteria,1WXAR@135613|Chromatiales 135613|Chromatiales NU TIGRFAM type IV-A pilus assembly ATPase PilB - - - ko:K02652 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE,T2SSE_N k59_482969_1 349521.HCH_00807 2.4e-51 178.0 COG3397@1|root,COG3397@2|Bacteria,1NP54@1224|Proteobacteria,1RV7U@1236|Gammaproteobacteria 1236|Gammaproteobacteria G Lytic polysaccharide mono-oxygenase, cellulose-degrading - - - ko:K03933 - - - - ko00000 - AA10,CBM73 - CBM_2,LPMO_10 k59_713958_1 316407.85675364 2.63e-94 276.0 COG2062@1|root,COG2062@2|Bacteria,1NAAE@1224|Proteobacteria,1SD0B@1236|Gammaproteobacteria,3XMMS@561|Escherichia 1236|Gammaproteobacteria T Phosphohistidine phosphatase sixA sixA GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0071704,GO:1901564 - ko:K08296 - - - - ko00000,ko01000 - - - His_Phos_1 k59_713958_2 316407.1799732 3.49e-41 149.0 COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,1RMZ8@1236|Gammaproteobacteria,3XMJZ@561|Escherichia 1236|Gammaproteobacteria I Catalyzes the formation of a hydroxyacyl-CoA by addition of water on enoyl-CoA. Also exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities fadJ GO:0003674,GO:0003824,GO:0003857,GO:0004300,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0008692,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016491,GO:0016614,GO:0016616,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016854,GO:0016856,GO:0019395,GO:0019752,GO:0030258,GO:0032787,GO:0034440,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0046395,GO:0055114,GO:0071704,GO:0072329,GO:1901575 1.1.1.35,4.2.1.17,5.1.2.3 ko:K01782 ko00071,ko00280,ko00281,ko00310,ko00362,ko00380,ko00410,ko00640,ko00650,ko00903,ko00930,ko01040,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00362,map00380,map00410,map00640,map00650,map00903,map00930,map01040,map01100,map01110,map01120,map01130,map01200,map01212 M00032,M00087 R01975,R03026,R03045,R03276,R04137,R04170,R04203,R04204,R04224,R04737,R04738,R04739,R04740,R04741,R04744,R04745,R04746,R04748,R04749,R05066,R05305,R06411,R06412,R06941,R06942,R07935,R07951,R08093,R08094 RC00029,RC00099,RC00117,RC00241,RC00525,RC00831,RC00834,RC00896,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 - - iECABU_c1320.ECABU_c26730,iETEC_1333.ETEC_2476,iEcE24377_1341.EcE24377A_2637,ic_1306.c2886 3HCDH,3HCDH_N,ECH_1 k59_1728787_1 1122137.AQXF01000003_gene1995 2.92e-10 59.7 COG0612@1|root,COG0612@2|Bacteria,1MVST@1224|Proteobacteria,2TRFB@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Belongs to the peptidase M16 family - - - ko:K07263 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M16,Peptidase_M16_C k59_1728787_2 1120953.AUBH01000008_gene259 1.68e-132 402.0 COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,1MUJ3@1224|Proteobacteria,1RRN4@1236|Gammaproteobacteria,4674P@72275|Alteromonadaceae 1236|Gammaproteobacteria EU Prolyl oligopeptidase, N-terminal beta-propeller domain - - - - - - - - - - - - PD40,Peptidase_S9,Peptidase_S9_N k59_884441_1 1088721.NSU_0754 6.55e-72 232.0 COG5362@1|root,COG5362@2|Bacteria,1R90H@1224|Proteobacteria,2U236@28211|Alphaproteobacteria,2K93W@204457|Sphingomonadales 204457|Sphingomonadales S TIGRFAM Phage - - - - - - - - - - - - - k59_1563024_1 1122137.AQXF01000007_gene3626 3.15e-143 414.0 COG3800@1|root,COG3800@2|Bacteria,1MU50@1224|Proteobacteria,2TRKE@28211|Alphaproteobacteria 28211|Alphaproteobacteria K transcriptional regulator - - - ko:K07110 - - - - ko00000,ko03000 - - - DUF2083,HTH_19,HTH_3,HTH_31,Peptidase_M78 k59_36397_1 875328.JDM601_3519 1.09e-25 105.0 COG1012@1|root,COG1012@2|Bacteria,2GIWZ@201174|Actinobacteria,233QF@1762|Mycobacteriaceae 201174|Actinobacteria C Aldehyde dehydrogenase - - 1.2.1.3 ko:K00128 ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130 M00135 R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146 RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_36397_2 1206720.BAFQ01000097_gene2491 3.04e-34 129.0 COG0028@1|root,COG0028@2|Bacteria,2GM6Y@201174|Actinobacteria,4FZBM@85025|Nocardiaceae 201174|Actinobacteria EH Thiamine pyrophosphate enzyme, central domain ilvG - 2.2.1.6,4.1.1.8 ko:K01577,ko:K01652 ko00290,ko00630,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00630,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R01908,R03050,R04672,R04673,R08648 RC00027,RC00106,RC00620,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_92249_1 247634.GPB2148_3732 1.44e-142 437.0 COG0439@1|root,COG0511@1|root,COG0439@2|Bacteria,COG0511@2|Bacteria,1N71M@1224|Proteobacteria,1RYJ9@1236|Gammaproteobacteria 1236|Gammaproteobacteria I COG0439 Biotin carboxylase - - - - - - - - - - - - Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2 k59_482977_1 203122.Sde_3828 3.2e-36 123.0 COG1278@1|root,COG1278@2|Bacteria,1N6Q5@1224|Proteobacteria,1S9KC@1236|Gammaproteobacteria,46BM7@72275|Alteromonadaceae 1236|Gammaproteobacteria K Cold shock protein domain cspA - - ko:K03704 - - - - ko00000,ko03000 - - - CSD k59_1330857_1 391615.ABSJ01000026_gene112 5.69e-132 401.0 COG0515@1|root,COG4252@1|root,COG0515@2|Bacteria,COG4252@2|Bacteria,1MV1P@1224|Proteobacteria,1RR36@1236|Gammaproteobacteria,1J6GE@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria KLT Protein tyrosine kinase - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - CHASE2,Pkinase k59_1164290_1 269800.Tfu_1530 6.86e-136 435.0 COG4770@1|root,COG4799@1|root,COG4770@2|Bacteria,COG4799@2|Bacteria,2GIZP@201174|Actinobacteria,4EMDF@85012|Streptosporangiales 201174|Actinobacteria I Acetyl-CoA carboxylase, central region - - - - - - - - - - - - ACC_central,Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2,Carboxyl_trans k59_1728799_2 768671.ThimaDRAFT_2244 3.34e-09 55.8 COG0268@1|root,COG0268@2|Bacteria,1MZ94@1224|Proteobacteria,1S9AI@1236|Gammaproteobacteria,1WYU8@135613|Chromatiales 135613|Chromatiales J Binds directly to 16S ribosomal RNA rpsT - - ko:K02968 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S20p k59_1392676_1 765420.OSCT_1257 1.11e-45 172.0 COG4191@1|root,COG4191@2|Bacteria,2G7PG@200795|Chloroflexi,3762S@32061|Chloroflexia 32061|Chloroflexia T histidine kinase A domain protein - - - - - - - - - - - - GAF_2,HATPase_c,HisKA,HisKA_7TM,PAS_4,PAS_8,Response_reg k59_1230554_1 316407.85676042 1.34e-108 321.0 COG1792@1|root,COG1792@2|Bacteria,1N8ZS@1224|Proteobacteria,1RMK4@1236|Gammaproteobacteria,3XNFQ@561|Escherichia 1236|Gammaproteobacteria M shape-determining protein MreC mreC GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0007163,GO:0008150,GO:0008360,GO:0009987,GO:0016020,GO:0016021,GO:0022603,GO:0022604,GO:0031224,GO:0031226,GO:0043621,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0065007,GO:0065008,GO:0071944,GO:0071963 - ko:K03570 - - - - ko00000,ko03036 9.B.157.1 - - MreC k59_1115805_1 1144305.PMI02_01595 2.01e-82 253.0 COG2175@1|root,COG2175@2|Bacteria,1MVI6@1224|Proteobacteria,2TVHF@28211|Alphaproteobacteria 28211|Alphaproteobacteria Q PFAM Taurine catabolism dioxygenase TauD, TfdA family MA20_18150 - - ko:K06912 ko00361,ko01120,ko01220,map00361,map01120,map01220 - R05419,R05493 RC01371,RC01372 ko00000,ko00001,ko01000 - - - TauD k59_1791193_2 999423.HMPREF9161_01721 8.74e-36 144.0 COG1419@1|root,COG1419@2|Bacteria,1TSP7@1239|Firmicutes,4H2XV@909932|Negativicutes 909932|Negativicutes N Flagellar biosynthesis flhF - - ko:K02404 - - - - ko00000,ko02035 - - - SRP54 k59_1791193_3 1089553.Tph_c11020 5.97e-14 73.6 COG1298@1|root,COG1298@2|Bacteria,1TQBM@1239|Firmicutes,248F5@186801|Clostridia,42EXH@68295|Thermoanaerobacterales 186801|Clostridia N Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin flhA - - ko:K02400 ko02040,map02040 - - - ko00000,ko00001,ko02035,ko02044 3.A.6.2,3.A.6.3 - - FHIPEP k59_834617_1 1122137.AQXF01000003_gene2372 1.38e-101 306.0 COG3844@1|root,COG3844@2|Bacteria,1MUKN@1224|Proteobacteria,2TR62@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively kynU - 3.7.1.3 ko:K01556 ko00380,ko01100,map00380,map01100 M00038 R00987,R02668,R03936 RC00284,RC00415 ko00000,ko00001,ko00002,ko01000 - - - Aminotran_5 k59_214210_1 886293.Sinac_4679 1.26e-08 62.0 2DBKQ@1|root,2Z9U7@2|Bacteria,2IWVD@203682|Planctomycetes 203682|Planctomycetes - - - - - - - - - - - - - - - k59_895245_2 1278073.MYSTI_01433 4.55e-96 292.0 COG1960@1|root,COG1960@2|Bacteria,1MUK0@1224|Proteobacteria,42QBB@68525|delta/epsilon subdivisions,2WKEZ@28221|Deltaproteobacteria,2YZQ4@29|Myxococcales 28221|Deltaproteobacteria C Acyl-CoA dehydrogenase, C-terminal domain - - 1.3.8.6 ko:K00252 ko00071,ko00310,ko00362,ko00380,ko01100,ko01120,ko01130,map00071,map00310,map00362,map00380,map01100,map01120,map01130 M00032 R02487,R02488,R10074 RC00052,RC00156 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_664069_1 1038922.PflQ2_1694 1.31e-29 119.0 COG3712@1|root,COG3712@2|Bacteria,1RGU3@1224|Proteobacteria,1S996@1236|Gammaproteobacteria,1YT3X@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria PT Domain of unknown function (DUF4974) - - - ko:K07165 - - - - ko00000 - - - DUF4880,DUF4974,FecR k59_1174565_2 1219035.NT2_01_01340 4.61e-52 166.0 COG0105@1|root,COG0105@2|Bacteria,1R9ZA@1224|Proteobacteria,2U5CS@28211|Alphaproteobacteria,2K3WY@204457|Sphingomonadales 204457|Sphingomonadales F Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate ndk - 2.7.4.6 ko:K00940 ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016 M00049,M00050,M00052,M00053 R00124,R00139,R00156,R00330,R00570,R00722,R01137,R01857,R02093,R02326,R02331,R03530,R11894,R11895 RC00002 ko00000,ko00001,ko00002,ko01000,ko04131 - - - NDK k59_945945_1 867845.KI911784_gene1530 5.03e-127 388.0 COG0366@1|root,COG0366@2|Bacteria 2|Bacteria G hydrolase activity, hydrolyzing O-glycosyl compounds glgE - 2.4.99.16 ko:K16147 ko00500,ko01100,map00500,map01100 - R09994 - ko00000,ko00001,ko01000 - GH13 - Alpha-amylase,DUF3416 k59_1573601_1 472759.Nhal_0352 4.75e-07 50.8 COG0079@1|root,COG0079@2|Bacteria,1MW7I@1224|Proteobacteria,1RP4T@1236|Gammaproteobacteria,1WX7G@135613|Chromatiales 135613|Chromatiales E Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily hisC2 - 2.6.1.9 ko:K00817 ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230 M00026 R00694,R00734,R03243 RC00006,RC00888 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 k59_1573601_2 396588.Tgr7_0213 7.87e-88 262.0 COG0131@1|root,COG0131@2|Bacteria,1MWBS@1224|Proteobacteria,1RPA9@1236|Gammaproteobacteria,1WVVY@135613|Chromatiales 135613|Chromatiales E imidazoleglycerol-phosphate dehydratase hisB - 4.2.1.19 ko:K01693 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R03457 RC00932 ko00000,ko00001,ko00002,ko01000 - - - IGPD k59_272195_2 1403313.AXBR01000023_gene2691 9.41e-33 127.0 COG0663@1|root,COG0663@2|Bacteria,1V2ZJ@1239|Firmicutes,4HTFD@91061|Bacilli,1ZG5G@1386|Bacillus 91061|Bacilli S Bacterial transferase hexapeptide (six repeats) - - - - - - - - - - - - Hexapep k59_46533_1 631362.Thi970DRAFT_03522 1.97e-62 201.0 COG0388@1|root,COG0388@2|Bacteria,1MXG5@1224|Proteobacteria,1RP7S@1236|Gammaproteobacteria,1WW9P@135613|Chromatiales 135613|Chromatiales S PFAM Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase - - 3.5.1.53 ko:K12251 ko00330,ko01100,map00330,map01100 - R01152 RC00096 ko00000,ko00001,ko01000 - - - CN_hydrolase k59_725073_1 670292.JH26_24495 5.04e-38 138.0 COG0151@1|root,COG0151@2|Bacteria,1MUAH@1224|Proteobacteria,2TQR5@28211|Alphaproteobacteria,1JSMC@119045|Methylobacteriaceae 28211|Alphaproteobacteria F Belongs to the GARS family purD - 6.3.4.13 ko:K01945 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04144 RC00090,RC00166 ko00000,ko00001,ko00002,ko01000 - - - GARS_A,GARS_C,GARS_N k59_725073_2 1122137.AQXF01000005_gene1304 3.02e-229 644.0 COG0642@1|root,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,2TQU3@28211|Alphaproteobacteria 28211|Alphaproteobacteria T Histidine kinase pdhS - - - - - - - - - - - HATPase_c,HisKA,PAS,PAS_4,PAS_8,PAS_9 k59_1626426_1 1379281.AVAG01000079_gene1558 5.75e-15 79.0 COG0019@1|root,COG0019@2|Bacteria,1MUA6@1224|Proteobacteria,42KZH@68525|delta/epsilon subdivisions,2WIRM@28221|Deltaproteobacteria,2M9PA@213115|Desulfovibrionales 28221|Deltaproteobacteria E Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine lysA - 4.1.1.20 ko:K01586 ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R00451 RC00299 ko00000,ko00001,ko00002,ko01000 - - - Orn_Arg_deC_N,Orn_DAP_Arg_deC k59_1284911_1 553385.JEMF01000030_gene2523 3.51e-53 180.0 COG0628@1|root,COG0628@2|Bacteria,1MW0B@1224|Proteobacteria,1RPVP@1236|Gammaproteobacteria,1XI8J@135619|Oceanospirillales 135619|Oceanospirillales S AI-2E family transporter - - - - - - - - - - - - AI-2E_transport k59_1063017_1 391625.PPSIR1_16165 3.27e-85 277.0 COG0189@1|root,COG0769@1|root,COG0189@2|Bacteria,COG0769@2|Bacteria,1MVN2@1224|Proteobacteria,42PUY@68525|delta/epsilon subdivisions,2WM1C@28221|Deltaproteobacteria,2YXTJ@29|Myxococcales 28221|Deltaproteobacteria HJ RimK-like ATP-grasp domain - - 6.3.2.29,6.3.2.30 ko:K03802 - - - - ko00000,ko01000 - - - Mur_ligase_C,Mur_ligase_M,RimK k59_156962_1 936455.KI421499_gene1953 3.86e-104 312.0 COG1028@1|root,COG1028@2|Bacteria,1MXNQ@1224|Proteobacteria,2TUHP@28211|Alphaproteobacteria,3JRVY@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria IQ Belongs to the short-chain dehydrogenases reductases (SDR) family MA20_35605 - - - - - - - - - - - adh_short k59_156962_2 1268622.AVS7_04238 7.57e-05 43.5 COG4770@1|root,COG4770@2|Bacteria 2|Bacteria I CoA carboxylase activity pccA - 6.4.1.3 ko:K01965,ko:K02160 ko00061,ko00280,ko00620,ko00630,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00280,map00620,map00630,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00373,M00376,M00741 R00742,R01859 RC00040,RC00097,RC00367,RC00609 ko00000,ko00001,ko00002,ko01000 - - - Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2 k59_156963_1 1123360.thalar_02887 4.12e-47 161.0 COG1999@1|root,COG1999@2|Bacteria 2|Bacteria M signal sequence binding sco - - ko:K07152 - - - - ko00000,ko03029 - - - SCO1-SenC k59_1454608_2 13690.CP98_02099 4.96e-57 181.0 2C2J5@1|root,315UG@2|Bacteria,1RHAH@1224|Proteobacteria,2U94W@28211|Alphaproteobacteria,2K4E5@204457|Sphingomonadales 204457|Sphingomonadales S Domain of unknown function (DUF3576) - - - - - - - - - - - - DUF3576 k59_386800_1 497964.CfE428DRAFT_5240 8.47e-128 370.0 COG2326@1|root,COG2326@2|Bacteria,46SAH@74201|Verrucomicrobia 74201|Verrucomicrobia S Polyphosphate kinase 2 (PPK2) - - - - - - - - - - - - PPK2 k59_1403764_1 2002.JOEQ01000002_gene4410 0.00013 50.1 COG0524@1|root,COG0524@2|Bacteria,2GP1C@201174|Actinobacteria,4EI81@85012|Streptosporangiales 201174|Actinobacteria G pfkB family carbohydrate kinase - - - - - - - - - - - - PfkB k59_1341199_1 765911.Thivi_3794 1.84e-28 115.0 COG0018@1|root,COG0018@2|Bacteria,1MU4J@1224|Proteobacteria,1RPRC@1236|Gammaproteobacteria,1WVYV@135613|Chromatiales 135613|Chromatiales J Arginyl-tRNA synthetase argS - 6.1.1.19 ko:K01887 ko00970,map00970 M00359,M00360 R03646 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d k59_1791236_1 1209072.ALBT01000039_gene187 4.81e-102 311.0 28HN6@1|root,2Z7WJ@2|Bacteria,1R5QB@1224|Proteobacteria,1RNJN@1236|Gammaproteobacteria,1FGDU@10|Cellvibrio 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_1454640_1 394.NGR_c35870 5.35e-59 197.0 COG1861@1|root,COG1861@2|Bacteria,1QU5J@1224|Proteobacteria,2U0ZH@28211|Alphaproteobacteria,4BJ1H@82115|Rhizobiaceae 28211|Alphaproteobacteria L Transposase DDE domain group 1 - - - - - - - - - - - - DDE_Tnp_1_4 k59_548954_1 349521.HCH_04931 4.25e-96 306.0 COG4251@1|root,COG5278@1|root,COG4251@2|Bacteria,COG5278@2|Bacteria,1NSQ1@1224|Proteobacteria,1RMUV@1236|Gammaproteobacteria,1XP3D@135619|Oceanospirillales 135619|Oceanospirillales T Histidine kinase-like ATPases - - - - - - - - - - - - HATPase_c k59_156998_1 1122137.AQXF01000005_gene1205 1.63e-58 184.0 COG2236@1|root,COG2236@2|Bacteria,1MXS1@1224|Proteobacteria,2U26S@28211|Alphaproteobacteria 28211|Alphaproteobacteria F Phosphoribosyl transferase domain - - - ko:K07101 - - - - ko00000 - - - Pribosyltran k59_156998_2 1122137.AQXF01000005_gene1206 1.04e-148 423.0 COG0005@1|root,COG0005@2|Bacteria,1MUWW@1224|Proteobacteria,2TSN3@28211|Alphaproteobacteria 28211|Alphaproteobacteria F Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates - - 2.4.2.1 ko:K03783,ko:K03815 ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110 - R01561,R01863,R01969,R02147,R02294,R02295,R02297,R02484,R02557,R02748,R08368,R10244 RC00033,RC00063,RC00122 ko00000,ko00001,ko01000 - - - PNP_UDP_1 k59_493385_1 436308.Nmar_0090 3.16e-26 104.0 COG1131@1|root,arCOG00194@2157|Archaea,41TB8@651137|Thaumarchaeota 651137|Thaumarchaeota E AAA domain, putative AbiEii toxin, Type IV TA system - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_1454652_1 247634.GPB2148_3144 6.91e-88 274.0 COG2072@1|root,COG2072@2|Bacteria,1MUQH@1224|Proteobacteria,1RP2E@1236|Gammaproteobacteria 1236|Gammaproteobacteria C flavoprotein involved in K transport - - - - - - - - - - - - FMO-like k59_1626479_1 1122201.AUAZ01000012_gene1368 2.01e-20 95.1 COG0557@1|root,COG0557@2|Bacteria,1MUS6@1224|Proteobacteria,1RMQE@1236|Gammaproteobacteria,464C0@72275|Alteromonadaceae 1236|Gammaproteobacteria J 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs rnr GO:0000175,GO:0003674,GO:0003724,GO:0003824,GO:0004386,GO:0004518,GO:0004527,GO:0004532,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008408,GO:0008997,GO:0009056,GO:0009057,GO:0009266,GO:0009409,GO:0009628,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010605,GO:0010629,GO:0016070,GO:0016071,GO:0016462,GO:0016787,GO:0016788,GO:0016796,GO:0016817,GO:0016818,GO:0016896,GO:0017111,GO:0019222,GO:0019439,GO:0034458,GO:0034470,GO:0034641,GO:0034655,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0050896,GO:0060255,GO:0065007,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0140098,GO:1901360,GO:1901361,GO:1901575 - ko:K12573 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03016,ko03019 - - - HTH_12,OB_RNB,RNB,S1 k59_46579_1 1379270.AUXF01000001_gene2672 7.25e-06 52.0 COG2084@1|root,COG2084@2|Bacteria,1ZT54@142182|Gemmatimonadetes 142182|Gemmatimonadetes I NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase - - 1.1.1.31 ko:K00020 ko00280,ko01100,map00280,map01100 - R05066 RC00099 ko00000,ko00001,ko01000 - - - NAD_binding_11,NAD_binding_2 k59_214308_1 59538.XP_005960765.1 5.31e-102 321.0 COG0318@1|root,KOG1177@2759|Eukaryota,38ES8@33154|Opisthokonta,3BHR0@33208|Metazoa,3CTUM@33213|Bilateria,48AEJ@7711|Chordata,48ZGR@7742|Vertebrata,3J5V3@40674|Mammalia,4JC7M@91561|Cetartiodactyla 33154|Opisthokonta I acyl-CoA synthetase family member 2 - - - - - - - - - - - - AMP-binding,AMP-binding_C k59_611946_2 1122137.AQXF01000002_gene531 3.7e-77 245.0 COG0477@1|root,COG2814@2|Bacteria,1MVSH@1224|Proteobacteria,2TUEW@28211|Alphaproteobacteria 28211|Alphaproteobacteria EGP Major facilitator Superfamily - - - - - - - - - - - - MFS_1,MFS_1_like,MFS_2,Sugar_tr k59_1516300_1 391615.ABSJ01000059_gene2180 5.3e-94 282.0 COG0016@1|root,COG0016@2|Bacteria,1MVD7@1224|Proteobacteria,1RN22@1236|Gammaproteobacteria,1J559@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily pheS GO:0003674,GO:0003824,GO:0004812,GO:0004826,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494 6.1.1.20 ko:K01889 ko00970,map00970 M00359,M00360 R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iSSON_1240.SSON_1444,iYL1228.KPN_02176 Phe_tRNA-synt_N,tRNA-synt_2d k59_611950_1 930166.CD58_00495 6.17e-47 163.0 COG1612@1|root,COG1612@2|Bacteria,1MVJ4@1224|Proteobacteria,1RQWB@1236|Gammaproteobacteria 1236|Gammaproteobacteria O Cytochrome oxidase assembly ctaA - - ko:K02259 ko00190,ko00860,ko01100,ko01110,ko02020,ko04714,map00190,map00860,map01100,map01110,map02020,map04714 M00154 R07412 RC00769 ko00000,ko00001,ko00002,ko03029 3.D.4.4 - - COX15-CtaA k59_725153_1 710686.Mycsm_05235 2.37e-65 213.0 COG2114@1|root,COG2267@1|root,COG2114@2|Bacteria,COG2267@2|Bacteria,2IASU@201174|Actinobacteria,232Z7@1762|Mycobacteriaceae 201174|Actinobacteria IT PFAM Adenylate and Guanylate cyclase catalytic domain - - - - - - - - - - - - Abhydrolase_1,Guanylate_cyc k59_214326_1 926569.ANT_19970 1.88e-96 300.0 COG0556@1|root,COG0556@2|Bacteria,2G5SU@200795|Chloroflexi 200795|Chloroflexi L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage uvrB - - ko:K03702 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - Helicase_C,ResIII,UVR,UvrB k59_775558_1 1385517.N800_00780 1.41e-87 278.0 COG0480@1|root,COG0480@2|Bacteria,1MVVY@1224|Proteobacteria,1RYCE@1236|Gammaproteobacteria,1X4EX@135614|Xanthomonadales 135614|Xanthomonadales J elongation factor G - - - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU k59_1403822_1 1191523.MROS_0218 5.72e-56 185.0 COG0050@1|root,COG0050@2|Bacteria 2|Bacteria J translation elongation factor activity tuf GO:0001666,GO:0001817,GO:0001819,GO:0002791,GO:0002793,GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0006950,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009274,GO:0009275,GO:0009628,GO:0009986,GO:0009987,GO:0010035,GO:0010038,GO:0010039,GO:0010339,GO:0010467,GO:0016020,GO:0019538,GO:0019899,GO:0022610,GO:0030312,GO:0032677,GO:0032757,GO:0032879,GO:0032880,GO:0034641,GO:0034645,GO:0035375,GO:0035821,GO:0036293,GO:0040007,GO:0042221,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044003,GO:0044068,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044403,GO:0044406,GO:0044419,GO:0044424,GO:0044426,GO:0044444,GO:0044462,GO:0044464,GO:0044650,GO:0044651,GO:0048518,GO:0048522,GO:0050707,GO:0050708,GO:0050714,GO:0050715,GO:0050789,GO:0050794,GO:0050896,GO:0051046,GO:0051047,GO:0051049,GO:0051050,GO:0051222,GO:0051223,GO:0051239,GO:0051240,GO:0051701,GO:0051704,GO:0051817,GO:0065007,GO:0070201,GO:0070482,GO:0071704,GO:0071944,GO:0090087,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903530,GO:1903532,GO:1904951,GO:2000482,GO:2000484 - ko:K02358,ko:K15771 ko02010,map02010 M00491 - - ko00000,ko00001,ko00002,ko02000,ko03012,ko03029,ko04147 3.A.1.1.16,3.A.1.1.2 - iSB619.SA_RS02960 GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3 k59_1739060_1 1117647.M5M_10205 4.33e-102 303.0 COG0414@1|root,COG0414@2|Bacteria,1MV1S@1224|Proteobacteria,1RMEG@1236|Gammaproteobacteria,1J4S2@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate panC GO:0003674,GO:0003824,GO:0004592,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006573,GO:0006575,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016874,GO:0016879,GO:0016881,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0042364,GO:0042398,GO:0042802,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901564,GO:1901566,GO:1901576,GO:1901605 6.3.2.1 ko:K01918 ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110 M00119 R02473 RC00096,RC00141 ko00000,ko00001,ko00002,ko01000 - - iECH74115_1262.ECH74115_0142,iECSP_1301.ECSP_0134,iECs_1301.ECs0137,iG2583_1286.G2583_0137,iZ_1308.Z0144 Pantoate_ligase k59_1174656_1 66373.JOFQ01000037_gene2297 1.63e-46 166.0 COG1541@1|root,COG1541@2|Bacteria,2IANT@201174|Actinobacteria 201174|Actinobacteria H Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA) - - - - - - - - - - - - - k59_1681794_1 1501230.ET33_36840 3.37e-52 174.0 COG0307@1|root,COG0307@2|Bacteria,1V1EP@1239|Firmicutes,4HC7B@91061|Bacilli,26QEM@186822|Paenibacillaceae 91061|Bacilli H Catalyzes the formation of riboflavin from 6,7-dimethyl-8-(1-D-ribityl)lumazine ribE GO:0003674,GO:0003824,GO:0004746,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.9 ko:K00793 ko00740,ko01100,ko01110,map00740,map01100,map01110 M00125 R00066 RC00958,RC00960 ko00000,ko00001,ko00002,ko01000 - - iSB619.SA_RS08950,iYO844.BSU23270 Lum_binding k59_1681794_2 1120949.KB903306_gene7272 4.39e-09 57.4 COG1494@1|root,COG1494@2|Bacteria,2GMQU@201174|Actinobacteria,4DASR@85008|Micromonosporales 201174|Actinobacteria G fructose-1,6-bisphosphatase glpX GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006094,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016051,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019203,GO:0019318,GO:0019319,GO:0019637,GO:0030145,GO:0030388,GO:0042132,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046364,GO:0046872,GO:0046914,GO:0050308,GO:0071704,GO:1901135,GO:1901576 3.1.3.11 ko:K02446 ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200 M00003,M00165,M00167 R00762,R04780 RC00017 ko00000,ko00001,ko00002,ko01000 - - - FBPase_glpX k59_102550_1 1122137.AQXF01000006_gene845 2.86e-94 277.0 COG1278@1|root,COG1278@2|Bacteria,1RAUE@1224|Proteobacteria,2U0S7@28211|Alphaproteobacteria 28211|Alphaproteobacteria K Cold shock cspB - - ko:K03704 - - - - ko00000,ko03000 - - - CSD k59_102550_2 1122137.AQXF01000006_gene846 5.16e-64 211.0 COG3067@1|root,COG3067@2|Bacteria,1MV0F@1224|Proteobacteria 1224|Proteobacteria P Na( ) H( ) antiporter that extrudes sodium in exchange for external protons nhaB GO:0003674,GO:0005215,GO:0005451,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006814,GO:0006873,GO:0006885,GO:0008150,GO:0008324,GO:0009987,GO:0010035,GO:0010038,GO:0010226,GO:0015075,GO:0015077,GO:0015078,GO:0015081,GO:0015291,GO:0015297,GO:0015298,GO:0015299,GO:0015318,GO:0015385,GO:0015491,GO:0015672,GO:0016020,GO:0019725,GO:0022804,GO:0022857,GO:0022890,GO:0030001,GO:0030003,GO:0030004,GO:0030641,GO:0034220,GO:0035725,GO:0042221,GO:0042592,GO:0044464,GO:0045851,GO:0046873,GO:0048878,GO:0050801,GO:0050896,GO:0051179,GO:0051234,GO:0051452,GO:0051453,GO:0055067,GO:0055080,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:0098771,GO:0099516,GO:1902600 - ko:K03314 - - - - ko00000,ko02000 2.A.34.1 - iECP_1309.ECP_1229,iLF82_1304.LF82_1485,iNRG857_1313.NRG857_06055,iUTI89_1310.UTI89_C1372 NhaB k59_330055_1 1123368.AUIS01000018_gene729 1.1e-89 280.0 COG0477@1|root,COG2814@2|Bacteria,1MU1I@1224|Proteobacteria,1RNTG@1236|Gammaproteobacteria,2NC1Z@225057|Acidithiobacillales 225057|Acidithiobacillales P major facilitator superfamily - - - ko:K03446 - M00701 - - ko00000,ko00002,ko02000 2.A.1.3 - - MFS_1 k59_493415_1 402881.Plav_1113 9.26e-40 149.0 COG5265@1|root,COG5265@2|Bacteria,1NSKS@1224|Proteobacteria,2UQAG@28211|Alphaproteobacteria,1JNC4@119043|Rhodobiaceae 28211|Alphaproteobacteria V ABC transporter transmembrane region atm1 GO:0003674,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0006732,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0006873,GO:0006875,GO:0006879,GO:0006996,GO:0007275,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009507,GO:0009526,GO:0009536,GO:0009555,GO:0009657,GO:0009658,GO:0009889,GO:0009941,GO:0009987,GO:0010035,GO:0010038,GO:0010288,GO:0010380,GO:0016020,GO:0016043,GO:0018130,GO:0019222,GO:0019538,GO:0019637,GO:0019720,GO:0019725,GO:0019866,GO:0022622,GO:0030003,GO:0031090,GO:0031323,GO:0031326,GO:0031966,GO:0031967,GO:0031975,GO:0032501,GO:0032502,GO:0042221,GO:0042592,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044422,GO:0044424,GO:0044429,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0046483,GO:0046686,GO:0046916,GO:0048229,GO:0048364,GO:0048731,GO:0048856,GO:0048878,GO:0050789,GO:0050790,GO:0050794,GO:0050801,GO:0050896,GO:0051171,GO:0051186,GO:0051188,GO:0051189,GO:0051193,GO:0051276,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0065007,GO:0065008,GO:0065009,GO:0071704,GO:0071840,GO:0090056,GO:0090407,GO:0098771,GO:0099402,GO:1901360,GO:1901362,GO:1901401,GO:1901463,GO:1901564,GO:1901566,GO:1901576 - ko:K06147 - - - - ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran k59_1115906_1 1123073.KB899241_gene2109 1.12e-07 58.5 COG1879@1|root,COG2374@1|root,COG1879@2|Bacteria,COG2374@2|Bacteria,1MX52@1224|Proteobacteria,1RRGN@1236|Gammaproteobacteria,1X3H2@135614|Xanthomonadales 135614|Xanthomonadales Q Lamin Tail Domain - - - - - - - - - - - - Calx-beta,LTD k59_775577_1 358681.BBR47_42540 2.1e-20 94.7 COG2244@1|root,COG2244@2|Bacteria,1VAKC@1239|Firmicutes,4HKJN@91061|Bacilli,26R4T@186822|Paenibacillaceae 91061|Bacilli S Polysaccharide biosynthesis protein - - - - - - - - - - - - MatE,Polysacc_synt,Polysacc_synt_C k59_895356_1 383381.EH30_11025 7.05e-08 54.7 2EP5S@1|root,33GSG@2|Bacteria,1NI0K@1224|Proteobacteria,2UK2B@28211|Alphaproteobacteria,2K7A6@204457|Sphingomonadales 204457|Sphingomonadales - - - - - - - - - - - - - - - k59_895357_1 1415778.JQMM01000001_gene1949 2.55e-07 55.8 COG2304@1|root,COG2304@2|Bacteria,1MW51@1224|Proteobacteria,1RMD3@1236|Gammaproteobacteria,1J59K@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S protein containing a von Willebrand factor type A (vWA) domain - - - ko:K07114 - - - - ko00000,ko02000 1.A.13.2.2,1.A.13.2.3 - - TPR_1,TPR_2,VWA_2 k59_1574884_1 395964.KE386496_gene2969 1.2e-155 452.0 COG2759@1|root,COG2759@2|Bacteria,1MUR8@1224|Proteobacteria,2TRMM@28211|Alphaproteobacteria,3NASQ@45404|Beijerinckiaceae 28211|Alphaproteobacteria F formate-tetrahydrofolate ligase activity fhs - 6.3.4.3 ko:K01938 ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200 M00140,M00377 R00943 RC00026,RC00111 ko00000,ko00001,ko00002,ko01000 - - - FTHFS k59_613109_1 504487.JCM19302_1569 3.13e-102 311.0 COG0488@1|root,COG0488@2|Bacteria,4NEHU@976|Bacteroidetes,1HXV7@117743|Flavobacteriia 976|Bacteroidetes S abc transporter (atp-binding protein) - - - - - - - - - - - - ABC_tran,ABC_tran_Xtn k59_47814_1 1198232.CYCME_1500 4.02e-166 475.0 COG0715@1|root,COG0715@2|Bacteria,1MWDN@1224|Proteobacteria,1RPUP@1236|Gammaproteobacteria,45ZQ1@72273|Thiotrichales 72273|Thiotrichales P NMT1-like family - - - ko:K15576 ko00910,ko02010,map00910,map02010 M00438 - - ko00000,ko00001,ko00002,ko02000 3.A.1.16.1,3.A.1.16.2 - - NMT1_2 k59_550114_1 1229909.NSED_07450 3.2e-79 253.0 COG0475@1|root,arCOG01956@2157|Archaea 2157|Archaea P Sodium hydrogen exchanger - - - - - - - - - - - - CBS,Na_H_Exchanger k59_1231755_1 1343158.SACS_0731 4.67e-77 247.0 COG0312@1|root,COG0312@2|Bacteria,1MUSK@1224|Proteobacteria,2TRSR@28211|Alphaproteobacteria,2JPFJ@204441|Rhodospirillales 204441|Rhodospirillales S peptidase U62, modulator of DNA gyrase tldD - - ko:K03568 - - - - ko00000,ko01002 - - - PmbA_TldD k59_1002951_1 1000565.METUNv1_03837 1.2e-64 213.0 COG0515@1|root,COG0664@1|root,COG0515@2|Bacteria,COG0664@2|Bacteria,1MV1P@1224|Proteobacteria,2VIE9@28216|Betaproteobacteria,2KU89@206389|Rhodocyclales 206389|Rhodocyclales KLT serine threonine protein kinase - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase,cNMP_binding k59_1682936_1 471852.Tcur_0712 1.05e-34 132.0 COG0566@1|root,COG0566@2|Bacteria,2GJMR@201174|Actinobacteria,4EIHA@85012|Streptosporangiales 201174|Actinobacteria J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family rlmB GO:0000154,GO:0000451,GO:0000453,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070039,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.185 ko:K03218 - - - - ko00000,ko01000,ko03009 - - - SpoU_methylase,SpoU_sub_bind k59_613119_1 941449.dsx2_2410 5.45e-103 329.0 COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,42M8F@68525|delta/epsilon subdivisions,2WIU0@28221|Deltaproteobacteria,2M7WE@213115|Desulfovibrionales 28221|Deltaproteobacteria P ATPase, P-type (transporting), HAD superfamily, subfamily IC pacL - 3.6.3.8 ko:K01537 - - - - ko00000,ko01000 3.A.3.2 - - Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3 k59_733523_1 545264.KB898755_gene2830 4.61e-140 409.0 COG1690@1|root,COG1690@2|Bacteria,1MUHA@1224|Proteobacteria,1RMXH@1236|Gammaproteobacteria,1WW29@135613|Chromatiales 135613|Chromatiales S PFAM Uncharacterised protein family UPF0027 rtcB - 6.5.1.3 ko:K14415 - - - - ko00000,ko01000,ko03016 - - - RtcB k59_1634784_1 745411.B3C1_04575 7.49e-78 248.0 COG2939@1|root,COG2939@2|Bacteria,1MW05@1224|Proteobacteria,1RQJY@1236|Gammaproteobacteria,1J58C@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E COG2939 Carboxypeptidase C (cathepsin A) - - - - - - - - - - - - Peptidase_S10 k59_672395_1 768671.ThimaDRAFT_1318 3.67e-61 197.0 COG2805@1|root,COG2805@2|Bacteria,1MU3J@1224|Proteobacteria,1RN8G@1236|Gammaproteobacteria,1WWZV@135613|Chromatiales 135613|Chromatiales NU PFAM Type II secretion system protein E - - - ko:K02669 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE k59_672395_2 1207076.ALAT01000030_gene117 4.68e-19 84.3 COG0325@1|root,COG0325@2|Bacteria,1MWN7@1224|Proteobacteria,1RNPM@1236|Gammaproteobacteria,1Z0N9@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria S Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis yggS - - ko:K06997 - - - - ko00000 - - - Ala_racemase_N k59_501309_1 1123517.JOMR01000001_gene657 2.17e-84 256.0 COG0852@1|root,COG0852@2|Bacteria,1MX4B@1224|Proteobacteria,1S2ET@1236|Gammaproteobacteria,460NB@72273|Thiotrichales 72273|Thiotrichales C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoC - 1.6.5.3 ko:K00332 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_30kDa k59_501309_2 84531.JMTZ01000012_gene2971 3.02e-36 132.0 COG0649@1|root,COG0649@2|Bacteria,1MVIN@1224|Proteobacteria,1RM98@1236|Gammaproteobacteria,1X3JR@135614|Xanthomonadales 135614|Xanthomonadales C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoD - 1.6.5.3 ko:K00333 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_30kDa,Complex1_49kDa k59_1463235_1 1121937.AUHJ01000003_gene3353 3.49e-24 110.0 COG1629@1|root,COG4771@2|Bacteria,1R7UN@1224|Proteobacteria,1S1JR@1236|Gammaproteobacteria 1236|Gammaproteobacteria P TonB dependent receptor - - - - - - - - - - - - Plug,TonB_dep_Rec k59_1293451_1 649639.Bcell_0886 4.1e-14 76.6 arCOG10317@1|root,2Z7VW@2|Bacteria,1UZAB@1239|Firmicutes,4HE48@91061|Bacilli,1ZG14@1386|Bacillus 91061|Bacilli - - - - - - - - - - - - - - - k59_1293451_2 1297570.MESS4_670035 1.17e-46 155.0 COG2149@1|root,COG2149@2|Bacteria,1N9QP@1224|Proteobacteria 1224|Proteobacteria S membrane - - - - - - - - - - - - DUF202 k59_1238640_1 1229909.NSED_02125 3.63e-47 161.0 COG0517@1|root,arCOG00601@2157|Archaea 2157|Archaea C CBS domain - - - - - - - - - - - - - k59_557225_1 1122137.AQXF01000002_gene182 7.49e-84 261.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2TQW2@28211|Alphaproteobacteria 28211|Alphaproteobacteria T COG2204 Response regulator containing CheY-like receiver AAA-type ATPase and DNA-binding domains ntrX - - ko:K13599 ko02020,map02020 M00498 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_733547_1 345341.KUTG_08194 7.53e-77 252.0 COG1132@1|root,COG1132@2|Bacteria,2GITR@201174|Actinobacteria,4DXBD@85010|Pseudonocardiales 201174|Actinobacteria V ABC-type multidrug transport system, ATPase and permease - - - ko:K06147 - - - - ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran k59_557227_1 493475.GARC_2101 1.52e-31 112.0 COG0633@1|root,COG0633@2|Bacteria,1RHDC@1224|Proteobacteria,1T0DU@1236|Gammaproteobacteria,46CKS@72275|Alteromonadaceae 1236|Gammaproteobacteria C 2Fe-2S iron-sulfur cluster binding domain fdx - - ko:K04755 - - - - ko00000 - - - Fer2 k59_843414_1 1266914.ATUK01000012_gene172 8.2e-94 293.0 COG5265@1|root,COG5265@2|Bacteria,1NSKS@1224|Proteobacteria,1T1W9@1236|Gammaproteobacteria,1WW1S@135613|Chromatiales 135613|Chromatiales V ABC transporter transmembrane region - - - ko:K06147 - - - - ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran k59_903562_1 1120953.AUBH01000002_gene1579 3.73e-48 169.0 COG1283@1|root,COG1283@2|Bacteria,1MUDE@1224|Proteobacteria,1S1YQ@1236|Gammaproteobacteria,46DG4@72275|Alteromonadaceae 1236|Gammaproteobacteria P Na+/Pi-cotransporter yjbB - - ko:K03324 - - - - ko00000,ko02000 2.A.58.2 - - Na_Pi_cotrans,PhoU k59_1634805_1 158500.BV97_00486 2.09e-95 284.0 COG0583@1|root,COG0583@2|Bacteria,1MU7H@1224|Proteobacteria,2TS72@28211|Alphaproteobacteria,2K1X2@204457|Sphingomonadales 204457|Sphingomonadales K Transcriptional regulator - - - - - - - - - - - - HTH_1,LysR_substrate k59_620641_1 640081.Dsui_3139 1.28e-57 192.0 COG1520@1|root,COG1520@2|Bacteria,1MXIJ@1224|Proteobacteria,2VHH5@28216|Betaproteobacteria,2KVKZ@206389|Rhodocyclales 206389|Rhodocyclales M Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane bamB - - ko:K17713 - - - - ko00000,ko02000 1.B.33.1 - - PQQ_2,PQQ_3 k59_783757_1 398512.JQKC01000001_gene2439 7.87e-42 148.0 arCOG10456@1|root,2ZA6T@2|Bacteria,1V06C@1239|Firmicutes,24GWM@186801|Clostridia 186801|Clostridia - - - - - - - - - - - - - - - k59_672419_1 1300345.LF41_18 9.2e-19 83.6 COG2086@1|root,COG2086@2|Bacteria,1MVH6@1224|Proteobacteria,1RN6F@1236|Gammaproteobacteria,1X34D@135614|Xanthomonadales 135614|Xanthomonadales C electron transfer flavoprotein beta subunit etfB - - ko:K03521 - - - - ko00000 - - - ETF k59_672419_2 596154.Alide2_1854 2.46e-09 60.5 COG2025@1|root,COG2025@2|Bacteria,1MUFI@1224|Proteobacteria,2VI6W@28216|Betaproteobacteria,4AHFN@80864|Comamonadaceae 28216|Betaproteobacteria C Electron transfer flavoprotein domain etfA - - ko:K03522 - - - - ko00000,ko04147 - - - ETF,ETF_alpha k59_1747066_1 436308.Nmar_0100 3.13e-94 287.0 COG0252@1|root,arCOG01924@2157|Archaea,41SD7@651137|Thaumarchaeota 651137|Thaumarchaeota J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate gatD - 6.3.5.7 ko:K09482 ko00970,ko01100,map00970,map01100 - R03905 RC00010 ko00000,ko00001,ko01000 - - - Asparaginase k59_954431_1 869213.JCM21142_3947 1.4e-21 99.0 COG1277@1|root,COG1277@2|Bacteria,4NI5T@976|Bacteroidetes,47TGW@768503|Cytophagia 976|Bacteroidetes S ABC-type transport system involved in multi-copper enzyme maturation permease component - - - - - - - - - - - - Peptidase_M1 k59_501348_1 979556.MTES_2791 4.58e-29 109.0 COG2151@1|root,COG2151@2|Bacteria,2II4H@201174|Actinobacteria,4FNUZ@85023|Microbacteriaceae 201174|Actinobacteria S Iron-sulfur cluster assembly protein paaJ - - ko:K02612 ko00360,ko01120,map00360,map01120 - R09838 RC02690 ko00000,ko00001 - - - FeS_assembly_P k59_501348_2 1122929.KB908240_gene308 2.21e-20 88.6 COG3396@1|root,COG3396@2|Bacteria,1MVYQ@1224|Proteobacteria,2TRYF@28211|Alphaproteobacteria 28211|Alphaproteobacteria S phenylacetic acid degradation protein paaI - 1.14.13.149 ko:K02611 ko00360,ko01120,map00360,map01120 - R09838 RC02690 ko00000,ko00001,ko01000 - - - PaaA_PaaC k59_557254_1 13690.CP98_03807 1.49e-57 194.0 COG2274@1|root,COG2274@2|Bacteria,1MXTI@1224|Proteobacteria,2TUN0@28211|Alphaproteobacteria,2K1TC@204457|Sphingomonadales 204457|Sphingomonadales V ABC transporter, ATP-binding protein - - - ko:K02021 - - - - ko00000,ko02000 3.A.1.106,3.A.1.110,3.A.1.112,3.A.1.113,3.A.1.117,3.A.1.21 - - ABC_membrane,ABC_tran k59_557254_2 13690.CP98_03808 7.4e-58 189.0 COG0845@1|root,COG0845@2|Bacteria,1PZ6R@1224|Proteobacteria,2TTYA@28211|Alphaproteobacteria,2K1H3@204457|Sphingomonadales 204457|Sphingomonadales M Biotin-lipoyl like - - - - - - - - - - - - Biotin_lipoyl_2,HlyD_3 k59_111067_2 1056820.KB900637_gene177 3.23e-16 79.3 COG0042@1|root,COG0042@2|Bacteria,1MUY1@1224|Proteobacteria,1RN28@1236|Gammaproteobacteria,2PN0V@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria J Dihydrouridine synthase (Dus) dusA GO:0002943,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016491,GO:0016627,GO:0017150,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055114,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 - ko:K05539 - - - - ko00000,ko01000,ko03016 - - - Dus k59_1238673_1 931627.MycrhDRAFT_2420 2.72e-07 61.2 COG2730@1|root,COG2730@2|Bacteria,2I2VY@201174|Actinobacteria,23FHM@1762|Mycobacteriaceae 201174|Actinobacteria G Calx-beta domain celA - 3.2.1.4 ko:K01179,ko:K20628 ko00500,ko01100,map00500,map01100 - R06200,R11307,R11308 - ko00000,ko00001,ko01000 - GH5,GH9 - CBM_2,Cellulase,fn3 k59_1182964_2 713586.KB900536_gene511 7.89e-56 178.0 COG1267@1|root,COG1267@2|Bacteria,1MZJA@1224|Proteobacteria,1S68A@1236|Gammaproteobacteria,1WY89@135613|Chromatiales 135613|Chromatiales I Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG) - - 3.1.3.27 ko:K01095 ko00564,ko01100,map00564,map01100 - R02029 RC00017 ko00000,ko00001,ko01000 - - - PgpA k59_165384_1 247633.GP2143_17971 4.44e-39 147.0 COG4993@1|root,COG4993@2|Bacteria,1MUQX@1224|Proteobacteria,1RN5D@1236|Gammaproteobacteria 1236|Gammaproteobacteria G Dehydrogenase - - - - - - - - - - - - PQQ,PQQ_2 k59_222569_1 1096930.L284_08300 7.13e-74 235.0 COG0330@1|root,COG0330@2|Bacteria,1MUM2@1224|Proteobacteria,2TRTP@28211|Alphaproteobacteria,2K20N@204457|Sphingomonadales 204457|Sphingomonadales O HflC and HflK could encode or regulate a protease hflK - - ko:K04088 - M00742 - - ko00000,ko00002,ko01000 - - - Band_7 k59_1349456_2 1122211.JMLW01000028_gene2768 8.93e-46 150.0 COG3436@1|root,COG3436@2|Bacteria,1MZFT@1224|Proteobacteria,1SABV@1236|Gammaproteobacteria,1XM0E@135619|Oceanospirillales 135619|Oceanospirillales L IS66 Orf2 like protein - - - ko:K07484 - - - - ko00000 - - - TnpB_IS66 k59_1349456_3 596151.DesfrDRAFT_2369 5.82e-07 52.4 COG3316@1|root,COG3316@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - DDE_Tnp_IS66,DDE_Tnp_IS66_C,LZ_Tnp_IS66,zf-IS66 k59_338313_1 1121374.KB891575_gene1514 1.55e-29 114.0 COG0579@1|root,COG0579@2|Bacteria,1N0QB@1224|Proteobacteria,1RN24@1236|Gammaproteobacteria 1236|Gammaproteobacteria S L-2-hydroxyglutarate oxidase LhgO lhgO - - ko:K15736 - - - - ko00000,ko01000 - - - DAO k59_338313_2 652103.Rpdx1_2036 6.52e-05 49.3 COG2244@1|root,COG2244@2|Bacteria,1MUMD@1224|Proteobacteria,2TTZ8@28211|Alphaproteobacteria,3JWU8@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S Polysaccharide biosynthesis protein - - - ko:K03328 - - - - ko00000 2.A.66.2 - - Polysacc_synt_3,Polysacc_synt_C k59_672463_1 1122137.AQXF01000006_gene801 7.9e-101 307.0 COG2939@1|root,COG2939@2|Bacteria,1MW05@1224|Proteobacteria,2TS7R@28211|Alphaproteobacteria 28211|Alphaproteobacteria E PFAM peptidase S10 serine carboxypeptidase - - - - - - - - - - - - Peptidase_S10 k59_501391_1 2903.EOD20987 1.58e-55 187.0 COG1960@1|root,KOG0141@2759|Eukaryota 2759|Eukaryota I isovaleryl-CoA dehydrogenase activity IVD GO:0000166,GO:0003674,GO:0003824,GO:0003853,GO:0003995,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005740,GO:0005759,GO:0006082,GO:0006139,GO:0006163,GO:0006195,GO:0006520,GO:0006551,GO:0006552,GO:0006629,GO:0006631,GO:0006635,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008470,GO:0009056,GO:0009058,GO:0009062,GO:0009063,GO:0009081,GO:0009083,GO:0009109,GO:0009117,GO:0009150,GO:0009154,GO:0009166,GO:0009259,GO:0009261,GO:0009987,GO:0016020,GO:0016042,GO:0016043,GO:0016054,GO:0016491,GO:0016627,GO:0017076,GO:0018130,GO:0019395,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0022607,GO:0030258,GO:0030554,GO:0031090,GO:0031966,GO:0031967,GO:0031974,GO:0031975,GO:0031981,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0033539,GO:0033865,GO:0033869,GO:0033875,GO:0034031,GO:0034032,GO:0034034,GO:0034404,GO:0034440,GO:0034641,GO:0034654,GO:0034655,GO:0035337,GO:0035383,GO:0035639,GO:0036094,GO:0036115,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0043603,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044249,GO:0044255,GO:0044270,GO:0044271,GO:0044273,GO:0044281,GO:0044282,GO:0044283,GO:0044422,GO:0044424,GO:0044428,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046395,GO:0046434,GO:0046483,GO:0046700,GO:0051186,GO:0051187,GO:0051259,GO:0051260,GO:0055086,GO:0055114,GO:0065003,GO:0070013,GO:0071704,GO:0071840,GO:0072329,GO:0072521,GO:0072523,GO:0097159,GO:0097367,GO:1901135,GO:1901136,GO:1901265,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901564,GO:1901565,GO:1901568,GO:1901569,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1902189,GO:1902190,GO:1902192,GO:1902195,GO:1902196,GO:1902198 1.3.8.4 ko:K00253 ko00280,ko01100,map00280,map01100 M00036 R04095 RC00246 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_55120_1 1219035.NT2_01_05870 6.59e-32 116.0 2EN6Y@1|root,33FUT@2|Bacteria,1NHQ0@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_1690208_2 1088721.NSU_2269 2.8e-18 83.6 COG2124@1|root,COG2124@2|Bacteria,1R3TW@1224|Proteobacteria,2TSBJ@28211|Alphaproteobacteria,2K25G@204457|Sphingomonadales 204457|Sphingomonadales C Cytochrome P450 - - - - - - - - - - - - p450 k59_1799517_1 330214.NIDE4165 6.84e-16 70.9 COG0425@1|root,COG0425@2|Bacteria,3J1C1@40117|Nitrospirae 40117|Nitrospirae O Sulfurtransferase TusA - - - - - - - - - - - - TusA k59_1690210_1 314287.GB2207_08236 1.43e-36 129.0 COG1495@1|root,COG1495@2|Bacteria,1RIJE@1224|Proteobacteria,1S6WD@1236|Gammaproteobacteria,1J6DM@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein dsbB - - ko:K03611 - - - - ko00000,ko03110 5.A.2.1 - - DsbB k59_1634863_1 1301098.PKB_0426 6.19e-68 215.0 COG0189@1|root,COG0189@2|Bacteria,1MVUA@1224|Proteobacteria,1RMU0@1236|Gammaproteobacteria 1236|Gammaproteobacteria H Belongs to the prokaryotic GSH synthase family gshB GO:0000287,GO:0003674,GO:0003824,GO:0004363,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006518,GO:0006575,GO:0006749,GO:0006750,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0019184,GO:0034641,GO:0042398,GO:0043043,GO:0043167,GO:0043169,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0051186,GO:0051188,GO:0071704,GO:1901564,GO:1901566,GO:1901576 6.3.2.3 ko:K01920 ko00270,ko00480,ko01100,map00270,map00480,map01100 M00118 R00497,R10994 RC00096,RC00141 ko00000,ko00001,ko00002,ko01000 - - iECED1_1282.ECED1_3410,iECP_1309.ECP_2941 GSH-S_ATP,GSH-S_N k59_954483_1 710111.FraQA3DRAFT_1729 8.98e-15 80.9 COG0451@1|root,COG0560@1|root,COG0451@2|Bacteria,COG0560@2|Bacteria,2GJVX@201174|Actinobacteria 201174|Actinobacteria E HAD-superfamily subfamily IB hydrolase, TIGR01490 - - - - - - - - - - - - HAD,NAD_binding_4,Sterile k59_447475_1 192875.XP_004364627.1 2.3e-66 217.0 KOG1406@1|root,KOG4170@1|root,KOG1406@2759|Eukaryota,KOG4170@2759|Eukaryota,38CKQ@33154|Opisthokonta 33154|Opisthokonta I propanoyl-CoA C-acyltransferase activity SCP2 GO:0000038,GO:0000062,GO:0000166,GO:0001676,GO:0002119,GO:0002164,GO:0003008,GO:0003674,GO:0003824,GO:0003988,GO:0005102,GO:0005215,GO:0005319,GO:0005488,GO:0005496,GO:0005504,GO:0005515,GO:0005548,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005740,GO:0005741,GO:0005777,GO:0005782,GO:0005783,GO:0005829,GO:0006066,GO:0006082,GO:0006139,GO:0006163,GO:0006605,GO:0006625,GO:0006629,GO:0006631,GO:0006635,GO:0006637,GO:0006694,GO:0006699,GO:0006700,GO:0006701,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006820,GO:0006869,GO:0006886,GO:0006996,GO:0007031,GO:0007275,GO:0007568,GO:0007610,GO:0007611,GO:0007612,GO:0007635,GO:0008104,GO:0008150,GO:0008152,GO:0008202,GO:0008206,GO:0008207,GO:0008289,GO:0008306,GO:0008355,GO:0008525,GO:0008526,GO:0008610,GO:0009056,GO:0009058,GO:0009062,GO:0009117,GO:0009150,GO:0009259,GO:0009719,GO:0009725,GO:0009791,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010033,GO:0010243,GO:0010817,GO:0010876,GO:0010883,GO:0010888,GO:0010893,GO:0010941,GO:0010942,GO:0012505,GO:0014070,GO:0015031,GO:0015248,GO:0015485,GO:0015711,GO:0015748,GO:0015833,GO:0015850,GO:0015914,GO:0015918,GO:0016020,GO:0016042,GO:0016043,GO:0016053,GO:0016054,GO:0016137,GO:0016138,GO:0016408,GO:0016740,GO:0016746,GO:0016747,GO:0017076,GO:0017127,GO:0017144,GO:0019216,GO:0019218,GO:0019222,GO:0019236,GO:0019395,GO:0019637,GO:0019693,GO:0019748,GO:0019751,GO:0019752,GO:0019867,GO:0019898,GO:0022611,GO:0030258,GO:0030301,GO:0030554,GO:0031090,GO:0031312,GO:0031315,GO:0031406,GO:0031907,GO:0031966,GO:0031967,GO:0031968,GO:0031974,GO:0031975,GO:0031981,GO:0032101,GO:0032355,GO:0032368,GO:0032370,GO:0032371,GO:0032373,GO:0032374,GO:0032376,GO:0032377,GO:0032379,GO:0032380,GO:0032382,GO:0032383,GO:0032385,GO:0032386,GO:0032388,GO:0032501,GO:0032502,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0032879,GO:0032934,GO:0032957,GO:0032958,GO:0032959,GO:0032991,GO:0033036,GO:0033218,GO:0033293,GO:0033365,GO:0033540,GO:0033559,GO:0033814,GO:0033865,GO:0033875,GO:0033993,GO:0034032,GO:0034440,GO:0034613,GO:0034641,GO:0034698,GO:0034699,GO:0034754,GO:0035383,GO:0036041,GO:0036042,GO:0036094,GO:0036109,GO:0036314,GO:0036315,GO:0040008,GO:0040012,GO:0040024,GO:0042048,GO:0042180,GO:0042181,GO:0042221,GO:0042445,GO:0042446,GO:0042448,GO:0042579,GO:0042802,GO:0042803,GO:0042810,GO:0042811,GO:0042886,GO:0042981,GO:0043053,GO:0043054,GO:0043065,GO:0043067,GO:0043068,GO:0043167,GO:0043168,GO:0043177,GO:0043178,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043434,GO:0043436,GO:0043574,GO:0043603,GO:0043647,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044249,GO:0044255,GO:0044281,GO:0044282,GO:0044283,GO:0044422,GO:0044424,GO:0044425,GO:0044428,GO:0044429,GO:0044438,GO:0044439,GO:0044444,GO:0044446,GO:0044455,GO:0044464,GO:0044550,GO:0045184,GO:0045540,GO:0045542,GO:0045834,GO:0045927,GO:0045940,GO:0046165,GO:0046173,GO:0046394,GO:0046395,GO:0046483,GO:0046889,GO:0046890,GO:0046907,GO:0046982,GO:0046983,GO:0048037,GO:0048518,GO:0048519,GO:0048522,GO:0048580,GO:0048582,GO:0048583,GO:0048638,GO:0048639,GO:0048856,GO:0050632,GO:0050662,GO:0050789,GO:0050793,GO:0050794,GO:0050810,GO:0050877,GO:0050890,GO:0050896,GO:0050920,GO:0051049,GO:0051050,GO:0051094,GO:0051179,GO:0051186,GO:0051234,GO:0051239,GO:0051240,GO:0051641,GO:0051649,GO:0051716,GO:0055086,GO:0055114,GO:0055115,GO:0060341,GO:0060620,GO:0061062,GO:0061063,GO:0062012,GO:0062013,GO:0065007,GO:0065008,GO:0070013,GO:0070538,GO:0070723,GO:0070727,GO:0070887,GO:0071310,GO:0071396,GO:0071397,GO:0071407,GO:0071702,GO:0071704,GO:0071705,GO:0071840,GO:0071981,GO:0072329,GO:0072330,GO:0072521,GO:0072594,GO:0072657,GO:0072659,GO:0072662,GO:0072663,GO:0080090,GO:0090181,GO:0090205,GO:0090407,GO:0097159,GO:0097305,GO:0097306,GO:0097367,GO:0098588,GO:0098805,GO:0106118,GO:0106120,GO:1901135,GO:1901137,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901373,GO:1901564,GO:1901567,GO:1901575,GO:1901576,GO:1901615,GO:1901617,GO:1901652,GO:1901657,GO:1901659,GO:1901681,GO:1901698,GO:1901700,GO:1901701,GO:1902930,GO:1902932,GO:1904069,GO:1904070,GO:1904109,GO:1904121,GO:1905952,GO:1905953,GO:1905954,GO:1990778,GO:2000026,GO:2000909,GO:2000911 2.3.1.176 ko:K08764 ko00120,ko01100,ko03320,ko04146,map00120,map01100,map03320,map04146 M00104 R03719,R04811 RC00004,RC00405,RC02725 ko00000,ko00001,ko00002,ko01000 - - - SCP2,Thiolase_C,Thiolase_N k59_844767_1 1122137.AQXF01000002_gene423 1.01e-106 329.0 COG1506@1|root,COG1506@2|Bacteria,1P6E1@1224|Proteobacteria,2TRVE@28211|Alphaproteobacteria 28211|Alphaproteobacteria E peptidase S9B dipeptidylpeptidase IV domain protein - - 3.4.14.5 ko:K01278 ko04974,map04974 - - - ko00000,ko00001,ko01000,ko01002,ko04090,ko04147 - - - DPPIV_N,Peptidase_S9 k59_447478_2 1379698.RBG1_1C00001G0560 2.99e-74 234.0 COG0483@1|root,COG0483@2|Bacteria,2NP94@2323|unclassified Bacteria 2|Bacteria G Inositol monophosphatase suhB GO:0003674,GO:0003824,GO:0005975,GO:0006020,GO:0006066,GO:0006793,GO:0006796,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0008934,GO:0009056,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019637,GO:0019751,GO:0023052,GO:0042578,GO:0043647,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0046164,GO:0046174,GO:0046434,GO:0046838,GO:0046855,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0052745,GO:0052834,GO:0065007,GO:0071545,GO:0071704,GO:1901575,GO:1901615,GO:1901616 3.1.3.25,3.1.3.7 ko:K01082,ko:K01092 ko00521,ko00562,ko00920,ko01100,ko01120,ko01130,ko04070,map00521,map00562,map00920,map01100,map01120,map01130,map04070 M00131 R00188,R00508,R01185,R01186,R01187 RC00078 ko00000,ko00001,ko00002,ko01000,ko03016 - - - Inositol_P k59_955631_2 313595.P700755_000678 3.54e-05 51.2 COG1721@1|root,COG1721@2|Bacteria,4NG0C@976|Bacteroidetes,1HXKI@117743|Flavobacteriia,4C2WM@83612|Psychroflexus 976|Bacteroidetes S Protein of unknown function DUF58 - - - - - - - - - - - - DUF58 k59_1748317_1 202698.XP_007387303.1 6.56e-23 105.0 COG1012@1|root,KOG2450@2759|Eukaryota,38CDB@33154|Opisthokonta,3NW4N@4751|Fungi,3UZQC@5204|Basidiomycota,2289I@155619|Agaricomycetes,3H2XK@355688|Agaricomycetes incertae sedis 4751|Fungi C Aldehyde dehydrogenase - GO:0006950,GO:0008150,GO:0009636,GO:0009987,GO:0033554,GO:0042221,GO:0050896,GO:0051410,GO:0051716,GO:0070458,GO:0070887,GO:0097237,GO:0098754,GO:1901698,GO:1990748 1.2.1.8 ko:K00130 ko00260,ko01100,map00260,map01100 M00555 R02565,R02566 RC00080 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_1464458_1 1286106.MPL1_02733 7.04e-08 62.4 COG1629@1|root,COG4771@2|Bacteria,1MWKN@1224|Proteobacteria,1RNTR@1236|Gammaproteobacteria 1236|Gammaproteobacteria P Receptor fyuA GO:0005575,GO:0005623,GO:0009279,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0044462,GO:0044464,GO:0071944 - ko:K02014,ko:K15721 - - - - ko00000,ko02000 1.B.14,1.B.14.7.2 - - Plug,TonB_dep_Rec k59_56413_1 349163.Acry_1243 1.01e-149 444.0 COG2225@1|root,COG2225@2|Bacteria,1MVEV@1224|Proteobacteria,2TS9R@28211|Alphaproteobacteria,2JPK5@204441|Rhodospirillales 204441|Rhodospirillales C Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA glcB - 2.3.3.9 ko:K01638 ko00620,ko00630,ko01100,ko01110,ko01120,ko01200,map00620,map00630,map01100,map01110,map01120,map01200 M00012 R00472 RC00004,RC00308,RC02747 ko00000,ko00001,ko00002,ko01000 - - - Malate_synthase k59_1691361_2 228410.NE1834 1.94e-78 249.0 COG0569@1|root,COG0569@2|Bacteria,1MW8R@1224|Proteobacteria,2VIH1@28216|Betaproteobacteria,3720Q@32003|Nitrosomonadales 28216|Betaproteobacteria C TrkA-N domain protein trkA - - ko:K03499 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - - TrkA_C,TrkA_N k59_844811_1 977880.RALTA_A1706 3.08e-57 188.0 COG2890@1|root,COG2890@2|Bacteria,1MX8Q@1224|Proteobacteria,2VIPK@28216|Betaproteobacteria,1K15E@119060|Burkholderiaceae 28216|Betaproteobacteria J Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue prmB - 2.1.1.298 ko:K07320 - - R10806 RC00003,RC03279 ko00000,ko01000,ko03009 - - - MTS k59_502634_1 1122137.AQXF01000003_gene2094 4e-83 270.0 COG0823@1|root,COG0823@2|Bacteria,1MWYK@1224|Proteobacteria,2VGDT@28211|Alphaproteobacteria 28211|Alphaproteobacteria U WD40-like Beta Propeller Repeat - - - - - - - - - - - - PD40 k59_558529_1 1005395.CSV86_23689 1.34e-14 77.8 COG2207@1|root,COG2207@2|Bacteria,1R73I@1224|Proteobacteria,1SYD3@1236|Gammaproteobacteria 1236|Gammaproteobacteria K AraC family transcriptional regulator - - - - - - - - - - - - Arabinose_bd,HTH_18 k59_1294825_1 1415778.JQMM01000001_gene41 4.24e-16 80.1 COG0795@1|root,COG0795@2|Bacteria,1MVW3@1224|Proteobacteria,1RM8H@1236|Gammaproteobacteria,1J4SM@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Permease lptG - - ko:K11720 ko02010,map02010 M00320 - - ko00000,ko00001,ko00002,ko02000 1.B.42.1 - - YjgP_YjgQ k59_1294825_2 1122169.AREN01000014_gene2652 0.000751 43.1 COG0795@1|root,COG0795@2|Bacteria,1MUF2@1224|Proteobacteria,1RMN5@1236|Gammaproteobacteria,1JDY9@118969|Legionellales 118969|Legionellales S Predicted permease YjgP/YjgQ family lptF - - ko:K07091 ko02010,map02010 M00320 - - ko00000,ko00001,ko00002,ko02000 1.B.42.1 - - YjgP_YjgQ k59_281984_1 1123229.AUBC01000016_gene4317 5.54e-114 347.0 COG0243@1|root,COG0243@2|Bacteria,1NR6J@1224|Proteobacteria,2TTAY@28211|Alphaproteobacteria,3JSTW@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family MA20_38000 - - - - - - - - - - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding k59_56425_1 316274.Haur_1891 7.01e-67 214.0 COG1131@1|root,COG1131@2|Bacteria,2G5RD@200795|Chloroflexi,37761@32061|Chloroflexia 32061|Chloroflexia V PFAM ABC transporter related - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_558539_2 756067.MicvaDRAFT_0903 4.28e-56 195.0 COG2208@1|root,COG4191@1|root,COG2208@2|Bacteria,COG4191@2|Bacteria,1G160@1117|Cyanobacteria,1H75U@1150|Oscillatoriales 1117|Cyanobacteria KT Stage II sporulation protein E - - 3.1.3.3 ko:K07315 - - - - ko00000,ko01000,ko03021 - - - CHASE2,HAMP,PAS,PAS_9,SpoIIE,dCache_1 k59_844838_1 1127673.GLIP_1210 1.15e-37 144.0 COG4805@1|root,COG4805@2|Bacteria,1MUBX@1224|Proteobacteria,1RMT7@1236|Gammaproteobacteria,466B9@72275|Alteromonadaceae 1236|Gammaproteobacteria S Bacterial protein of unknown function (DUF885) - - - - - - - - - - - - DUF885 k59_1294840_1 314231.FP2506_01995 7.01e-78 246.0 COG0399@1|root,COG0399@2|Bacteria,1MUPN@1224|Proteobacteria,2TVTA@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Belongs to the DegT DnrJ EryC1 family - - 2.6.1.102 ko:K13010 ko00520,map00520 - R10460 RC00006,RC00781 ko00000,ko00001,ko01000,ko01005,ko01007 - - - DegT_DnrJ_EryC1 k59_166748_1 1267005.KB911258_gene478 2.95e-07 50.8 COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2TQR1@28211|Alphaproteobacteria 28211|Alphaproteobacteria C belongs to the aldehyde dehydrogenase family MA20_17005 - 1.2.1.3 ko:K00128 ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130 M00135 R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146 RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_1748365_1 207954.MED92_01871 4.38e-37 142.0 COG2812@1|root,COG2812@2|Bacteria,1MVCK@1224|Proteobacteria,1RMIA@1236|Gammaproteobacteria,1XHPB@135619|Oceanospirillales 135619|Oceanospirillales L DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity dnaX - 2.7.7.7 ko:K02343 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_delta2,DNA_pol3_gamma3,DNA_pol3_tau_5 k59_955670_1 1122137.AQXF01000003_gene2256 1.02e-116 343.0 COG0332@1|root,COG0332@2|Bacteria,1MU9N@1224|Proteobacteria,2TU94@28211|Alphaproteobacteria 28211|Alphaproteobacteria I COG0332 3-oxoacyl- acyl-carrier-protein synthase III fabH_2 - 2.3.1.207 ko:K16872 - - - - ko00000,ko01000 - - - ACP_syn_III,ACP_syn_III_C k59_844859_1 991905.SL003B_0365 2.14e-06 48.5 COG0473@1|root,COG0473@2|Bacteria,1MUH4@1224|Proteobacteria,2TQKG@28211|Alphaproteobacteria,4BP7K@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria CE Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate leuB GO:0003674,GO:0003824,GO:0003862,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.85 ko:K00052 ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230 M00432,M00535 R00994,R04426,R10052 RC00084,RC00417,RC03036 br01601,ko00000,ko00001,ko00002,ko01000 - - - Iso_dh k59_844859_2 1122137.AQXF01000007_gene3534 9.02e-109 317.0 COG0066@1|root,COG0066@2|Bacteria,1MVXB@1224|Proteobacteria,2TRRS@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate leuD - 4.2.1.33,4.2.1.35 ko:K01704 ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230 M00432,M00535 R03896,R03898,R03968,R04001,R10170 RC00976,RC00977,RC01041,RC01046,RC03072 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase_C k59_844859_3 1122137.AQXF01000007_gene3535 5.38e-99 300.0 COG0065@1|root,COG0065@2|Bacteria,1MVYR@1224|Proteobacteria,2TR6K@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate leuC - 4.2.1.33,4.2.1.35 ko:K01703 ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230 M00432,M00535 R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170 RC00497,RC00976,RC00977,RC01041,RC01046,RC03072 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase k59_502648_1 1122137.AQXF01000006_gene920 5.24e-161 473.0 COG0542@1|root,COG0542@2|Bacteria,1MV8B@1224|Proteobacteria,2TQUZ@28211|Alphaproteobacteria 28211|Alphaproteobacteria O Belongs to the ClpA ClpB family clpA GO:0000166,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0043335,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0070011,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564 - ko:K03694 - - - - ko00000,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N k59_56448_1 697281.Mahau_2606 4.45e-60 207.0 COG3250@1|root,COG3250@2|Bacteria,1TPK7@1239|Firmicutes,247VE@186801|Clostridia,42I1G@68295|Thermoanaerobacterales 186801|Clostridia G glycoside hydrolase family 2 immunoglobulin domain protein beta-sandwich - - 3.2.1.23 ko:K01190 ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100 - R01105,R01678,R03355,R04783,R06114 RC00049,RC00452 ko00000,ko00001,ko01000 - - - DUF4982,Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N k59_502655_1 477228.YO5_17350 1.26e-44 151.0 COG0494@1|root,COG0494@2|Bacteria,1RCX7@1224|Proteobacteria,1S3ZE@1236|Gammaproteobacteria,1Z1QK@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria L COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes nudE GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0019144,GO:0043167,GO:0043169,GO:0044424,GO:0044444,GO:0044464,GO:0046872 - ko:K08312 ko00230,map00230 - R01054 RC00002 ko00000,ko00001,ko01000 - - iAPECO1_1312.APECO1_3067,iE2348C_1286.E2348C_3641,iECABU_c1320.ECABU_c38150,iECED1_1282.ECED1_4056,iECNA114_1301.ECNA114_3494,iECOK1_1307.ECOK1_3810,iECP_1309.ECP_3483,iECS88_1305.ECS88_3783,iECSF_1327.ECSF_3218,iLF82_1304.LF82_1531,iNRG857_1313.NRG857_16815,iUMN146_1321.UM146_17040,iUTI89_1310.UTI89_C3895,ic_1306.c4167 NUDIX k59_558571_1 1123258.AQXZ01000017_gene4154 1.16e-110 330.0 COG0183@1|root,COG0183@2|Bacteria,2GJAC@201174|Actinobacteria,4FWJQ@85025|Nocardiaceae 201174|Actinobacteria I Belongs to the thiolase family - - 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N k59_796188_1 309803.CTN_0802 3.65e-19 87.8 COG0039@1|root,COG0039@2|Bacteria,2GBX4@200918|Thermotogae 200918|Thermotogae C Belongs to the LDH MDH superfamily. LDH family ldh - 1.1.1.27 ko:K00016 ko00010,ko00270,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko04922,map00010,map00270,map00620,map00640,map01100,map01110,map01120,map01130,map04922 - R00703,R01000,R03104 RC00031,RC00044 ko00000,ko00001,ko01000,ko04147 - - - Ldh_1_C,Ldh_1_N k59_739916_2 243232.MJ_0963 5.04e-44 159.0 COG0146@1|root,arCOG01512@2157|Archaea,2Y8DU@28890|Euryarchaeota 28890|Euryarchaeota E COG0146 N-methylhydantoinase B acetone carboxylase, alpha subunit - GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006518,GO:0006575,GO:0006749,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016810,GO:0016812,GO:0017168,GO:0034641,GO:0043603,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0051186,GO:0071704,GO:1901564 3.5.2.14 ko:K01474 ko00330,ko01100,map00330,map01100 - R03187 RC00632 ko00000,ko00001,ko01000 - - - Hydantoinase_B k59_174821_1 314285.KT71_15259 3.88e-89 283.0 COG1231@1|root,COG1231@2|Bacteria,1QXX6@1224|Proteobacteria,1T3IZ@1236|Gammaproteobacteria,1J5KT@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E K COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit - - 1.5.99.6 ko:K00316 ko00330,ko00410,ko01100,map00330,map00410,map01100 - R01914,R01915 RC00053,RC00225 ko00000,ko00001,ko01000 - - - NAD_binding_8 k59_1361011_1 316407.1742480 4.72e-116 345.0 COG1070@1|root,COG1070@2|Bacteria,1MWS5@1224|Proteobacteria,1RRKR@1236|Gammaproteobacteria,3XQXQ@561|Escherichia 1236|Gammaproteobacteria G Catalyzes the phosphorylation of autoinducer-2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of (S)-4,5-dihydroxypentane-2,3- dione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position lsrK GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009372,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0042710,GO:0044010,GO:0044237,GO:0044764,GO:0051704,GO:0071518 2.7.1.17,2.7.1.189 ko:K00854,ko:K11216 ko00040,ko01100,ko02024,map00040,map01100,map02024 M00014 R01639,R11183 RC00002,RC00017,RC00538 ko00000,ko00001,ko00002,ko01000 - - - FGGY_C,FGGY_N k59_287846_2 105559.Nwat_2740 6.38e-29 112.0 COG0543@1|root,COG0543@2|Bacteria,1RF43@1224|Proteobacteria,1RQ7W@1236|Gammaproteobacteria,1X286@135613|Chromatiales 135613|Chromatiales C Oxidoreductase FAD-binding domain - - - ko:K02823 ko00240,ko01100,map00240,map01100 - - - ko00000,ko00001 - - - DHODB_Fe-S_bind k59_1078417_1 746697.Aeqsu_1587 2.41e-30 120.0 COG3488@1|root,COG3488@2|Bacteria,4NGBS@976|Bacteroidetes,1HY8W@117743|Flavobacteriia 976|Bacteroidetes C Thiol oxidoreductase - - - - - - - - - - - - DHOR k59_400631_1 1125863.JAFN01000001_gene489 5e-79 246.0 COG3243@1|root,COG3243@2|Bacteria,1MU68@1224|Proteobacteria,42MW8@68525|delta/epsilon subdivisions,2WKI6@28221|Deltaproteobacteria 28221|Deltaproteobacteria I Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus phaC - - ko:K03821 ko00650,map00650 - R04254 RC00004 ko00000,ko00001,ko01000 - - - Abhydrolase_1 k59_1530429_1 640512.BC1003_0729 7.45e-68 218.0 COG3328@1|root,COG3328@2|Bacteria,1MU4P@1224|Proteobacteria,2VKD6@28216|Betaproteobacteria,1K2MR@119060|Burkholderiaceae 28216|Betaproteobacteria L PFAM transposase mutator type - - - - - - - - - - - - Transposase_mut k59_570054_1 472759.Nhal_2695 9.63e-86 271.0 COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,1RMNZ@1236|Gammaproteobacteria,1WW8W@135613|Chromatiales 135613|Chromatiales I Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA acsA - 6.2.1.1 ko:K01895 ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200 M00357 R00235,R00236,R00316,R00926,R01354 RC00004,RC00012,RC00043,RC00070,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000,ko01004 - - - ACAS_N,AMP-binding,AMP-binding_C k59_965470_1 1123320.KB889682_gene2117 2.66e-09 63.2 COG2936@1|root,COG2936@2|Bacteria,2GK8B@201174|Actinobacteria 2|Bacteria IQ Peptidase S15 - - - - - - - - - - - - PepX_C,Peptidase_S15 k59_400634_1 632518.Calow_0747 2.74e-44 160.0 COG0153@1|root,COG0153@2|Bacteria,1TPD0@1239|Firmicutes,247U8@186801|Clostridia,42HNC@68295|Thermoanaerobacterales 186801|Clostridia F Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) galK - 2.7.1.6 ko:K00849 ko00052,ko00520,ko01100,map00052,map00520,map01100 M00554,M00632 R01092 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000,ko04147 - - - GHMP_kinases_C,GHMP_kinases_N,GalKase_gal_bdg k59_1304554_1 1038860.AXAP01000056_gene3507 2.45e-47 171.0 COG0421@1|root,COG0421@2|Bacteria,1P220@1224|Proteobacteria,2U4F6@28211|Alphaproteobacteria,3JVSX@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria E Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine - - - - - - - - - - - - - k59_1586749_1 765420.OSCT_2206 2.02e-22 102.0 COG2203@1|root,COG5002@1|root,COG2203@2|Bacteria,COG5002@2|Bacteria,2GABQ@200795|Chloroflexi,3751C@32061|Chloroflexia 32061|Chloroflexia T histidine kinase A domain protein - - - - - - - - - - - - DUF3369,GAF,GAF_2,HATPase_c,HisKA,PAS_4 k59_1586750_2 1229909.NSED_01285 1.46e-126 359.0 COG0377@1|root,arCOG01554@2157|Archaea,41S6D@651137|Thaumarchaeota 651137|Thaumarchaeota C Belongs to the complex I 20 kDa subunit family - - 1.6.5.3 ko:K00331 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q6 k59_796229_1 1209072.ALBT01000013_gene3529 1.12e-69 233.0 COG1026@1|root,COG1026@2|Bacteria,1MVDJ@1224|Proteobacteria,1RYNI@1236|Gammaproteobacteria,1FGZJ@10|Cellvibrio 1236|Gammaproteobacteria S Peptidase M16C associated - - - ko:K06972 - - - - ko00000,ko01000,ko01002 - - - M16C_assoc,Peptidase_M16,Peptidase_M16_C k59_400648_1 1123504.JQKD01000021_gene5709 1.2e-12 73.2 COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,2VN2C@28216|Betaproteobacteria,4AJ2R@80864|Comamonadaceae 28216|Betaproteobacteria C Acyl-CoA dehydrogenase, type 2, C-terminal domain - - 1.3.8.3,1.3.8.7 ko:K00249,ko:K07545 ko00071,ko00280,ko00410,ko00623,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko01220,ko03320,map00071,map00280,map00410,map00623,map00640,map01100,map01110,map01120,map01130,map01200,map01212,map01220,map03320 M00013,M00036,M00087,M00418 R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754,R05584 RC00052,RC00068,RC00076,RC00095,RC00148,RC00246,RC02037 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_287879_1 1122137.AQXF01000003_gene1967 7.14e-200 580.0 COG1629@1|root,COG4774@1|root,COG1629@2|Bacteria,COG4774@2|Bacteria,1MWS3@1224|Proteobacteria,2TWDV@28211|Alphaproteobacteria 28211|Alphaproteobacteria P TonB-dependent receptor - - - - - - - - - - - - Plug,TonB_dep_Rec k59_682945_1 566466.NOR53_420 2.55e-12 69.3 2EM9G@1|root,33EYK@2|Bacteria,1P8EM@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_739933_1 190650.CC_1432 2.63e-91 281.0 COG0183@1|root,COG0183@2|Bacteria,1MU8C@1224|Proteobacteria,2TS6P@28211|Alphaproteobacteria,2KH7Z@204458|Caulobacterales 204458|Caulobacterales I Belongs to the thiolase family - - 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N k59_797487_2 199310.c3871 5.16e-29 106.0 COG0251@1|root,COG0251@2|Bacteria,1MZ3J@1224|Proteobacteria,1S5XS@1236|Gammaproteobacteria,3XPIQ@561|Escherichia 1236|Gammaproteobacteria E May be a post-translational regulator that controls the metabolic fate of L-threonine or the potentially toxic intermediate 2-ketobutyrate tdcF GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006082,GO:0006520,GO:0006566,GO:0006807,GO:0008150,GO:0008152,GO:0009066,GO:0009987,GO:0016787,GO:0019239,GO:0019752,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0071704,GO:1901564,GO:1901605 3.5.99.10 ko:K09022 - - R11098,R11099 RC03275,RC03354 ko00000,ko01000 - - - Ribonuc_L-PSP k59_627640_1 646529.Desaci_0588 1.96e-08 52.0 COG0347@1|root,COG0347@2|Bacteria,1V9Z5@1239|Firmicutes,24MNA@186801|Clostridia,262KR@186807|Peptococcaceae 186801|Clostridia K nitrogen regulatory protein P-II - - - ko:K04751 ko02020,map02020 - - - ko00000,ko00001 - - - P-II k59_627640_2 1463861.JNXE01000021_gene4171 1.67e-28 112.0 COG1082@1|root,COG1082@2|Bacteria 2|Bacteria G myo-inosose-2 dehydratase activity - - - - - - - - - - - - AP_endonuc_2 k59_289200_1 985665.HPL003_11215 2.77e-11 64.7 COG0589@1|root,COG0589@2|Bacteria,1V6RY@1239|Firmicutes,4HIZM@91061|Bacilli,26YHS@186822|Paenibacillaceae 91061|Bacilli T Universal stress protein uspA1 - - - - - - - - - - - Usp k59_289200_2 930945.SiRe_2402 2.41e-16 77.8 COG0589@1|root,arCOG02053@2157|Archaea,2XQTK@28889|Crenarchaeota 28889|Crenarchaeota T PFAM UspA domain protein - - - - - - - - - - - - Usp k59_175733_1 1123368.AUIS01000018_gene730 5.01e-34 129.0 COG1566@1|root,COG1566@2|Bacteria,1MU7I@1224|Proteobacteria,1RPCV@1236|Gammaproteobacteria 1236|Gammaproteobacteria V secretion protein HlyD - - - ko:K03543 - M00701 - - ko00000,ko00002,ko02000 8.A.1.1 - - Biotin_lipoyl_2,HlyD_3,HlyD_D23 k59_63245_1 1122137.AQXF01000001_gene3145 1.32e-73 229.0 COG0714@1|root,COG0714@2|Bacteria,1MXIW@1224|Proteobacteria,2TS1Z@28211|Alphaproteobacteria 28211|Alphaproteobacteria S cobaltochelatase, CobS subunit cobS - 6.6.1.2 ko:K09882 ko00860,ko01100,map00860,map01100 - R05227 RC02000 ko00000,ko00001,ko01000 - - - AAA_5,CbbQ_C,CobS_N k59_966521_1 983544.Lacal_1777 1.46e-106 314.0 28IS5@1|root,2Z8RB@2|Bacteria,4NIIH@976|Bacteroidetes,1HZWV@117743|Flavobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_1136003_1 177439.DP1676 5.77e-39 146.0 COG0741@1|root,COG1388@1|root,COG0741@2|Bacteria,COG1388@2|Bacteria,1MWKE@1224|Proteobacteria,42M5C@68525|delta/epsilon subdivisions,2WJ54@28221|Deltaproteobacteria,2MJ3U@213118|Desulfobacterales 28221|Deltaproteobacteria M Lytic transglycosylase catalytic mltD2 - - ko:K08307 - - - - ko00000,ko01000,ko01011 - - - LysM,SLT k59_514329_1 879308.HMPREF9130_2143 3.16e-16 80.1 COG0157@1|root,COG0157@2|Bacteria,1TPQC@1239|Firmicutes,248P2@186801|Clostridia 186801|Clostridia H Belongs to the NadC ModD family nadC - 2.4.2.19 ko:K00767 ko00760,ko01100,map00760,map01100 M00115 R03348 RC02877 ko00000,ko00001,ko00002,ko01000 - - iHN637.CLJU_RS12010 QRPTase_C,QRPTase_N k59_683994_2 391615.ABSJ01000002_gene509 1.12e-18 80.9 COG1534@1|root,COG1534@2|Bacteria,1N8K5@1224|Proteobacteria,1SDIM@1236|Gammaproteobacteria,1J6YZ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J RNA-binding protein containing KH domain, possibly ribosomal protein yhbY GO:0000027,GO:0000028,GO:0000966,GO:0000967,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016072,GO:0022607,GO:0022613,GO:0022618,GO:0034470,GO:0034471,GO:0034622,GO:0034641,GO:0034660,GO:0042254,GO:0042255,GO:0042273,GO:0042274,GO:0043021,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:1901360,GO:1990275 - ko:K07574 - - - - ko00000,ko03009 - - - CRS1_YhbY k59_1079396_1 1003195.SCAT_3793 5.07e-104 312.0 COG1816@1|root,COG1816@2|Bacteria,2GJ6I@201174|Actinobacteria 201174|Actinobacteria F Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism add GO:0003674,GO:0003824,GO:0004000,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006144,GO:0006152,GO:0006154,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009112,GO:0009113,GO:0009116,GO:0009119,GO:0009163,GO:0009164,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0017144,GO:0018130,GO:0019239,GO:0019438,GO:0019439,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0042278,GO:0042440,GO:0042451,GO:0042454,GO:0042455,GO:0042737,GO:0043094,GO:0043096,GO:0043101,GO:0043103,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046085,GO:0046100,GO:0046101,GO:0046102,GO:0046103,GO:0046112,GO:0046128,GO:0046129,GO:0046130,GO:0046148,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0072523,GO:1901135,GO:1901136,GO:1901137,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901657,GO:1901658,GO:1901659 3.5.4.4 ko:K01488 ko00230,ko01100,ko05340,map00230,map01100,map05340 - R01560,R02556 RC00477 ko00000,ko00001,ko01000 - - iNJ661.Rv3313c A_deaminase k59_797505_1 2340.JV46_27180 5.02e-126 367.0 COG2041@1|root,COG2041@2|Bacteria,1MUW0@1224|Proteobacteria,1RQ2J@1236|Gammaproteobacteria,1J5HC@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide msrP GO:0000302,GO:0001101,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009987,GO:0010035,GO:0016491,GO:0016667,GO:0016672,GO:0016675,GO:0019538,GO:0030091,GO:0030288,GO:0030313,GO:0031975,GO:0042221,GO:0042597,GO:0043170,GO:0043546,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0048037,GO:0050662,GO:0050896,GO:0055114,GO:0071704,GO:0097159,GO:1901363,GO:1901530,GO:1901564,GO:1901700 - ko:K07147 - - - - ko00000,ko01000 - - - Oxidored_molyb k59_797505_2 999541.bgla_1g03390 9.61e-50 166.0 COG2717@1|root,COG2717@2|Bacteria,1RDUP@1224|Proteobacteria,2VRBQ@28216|Betaproteobacteria,1K3TE@119060|Burkholderiaceae 28216|Betaproteobacteria C Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain msrQ - - ko:K17247 - - - - ko00000 - - - Ferric_reduct k59_1644906_1 1122137.AQXF01000002_gene355 1.04e-216 604.0 COG0439@1|root,COG0439@2|Bacteria,1MU4H@1224|Proteobacteria,2U25Z@28211|Alphaproteobacteria 28211|Alphaproteobacteria I An AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism accC GO:0003674,GO:0003824,GO:0004075,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0016053,GO:0016874,GO:0016879,GO:0019216,GO:0019217,GO:0019222,GO:0019752,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032787,GO:0042304,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046394,GO:0046890,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051055,GO:0062012,GO:0062014,GO:0065007,GO:0071704,GO:0072330,GO:0080090,GO:1901576 6.3.4.14,6.4.1.2 ko:K01961 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04385 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 - - - Biotin_carb_C,Biotin_carb_N,CPSase_L_D2 k59_1644906_2 1208323.B30_03602 4.46e-07 50.4 COG2360@1|root,COG2360@2|Bacteria,1R9W8@1224|Proteobacteria,2U59K@28211|Alphaproteobacteria 28211|Alphaproteobacteria O Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine aat GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008914,GO:0016740,GO:0016746,GO:0016755,GO:0044424,GO:0044464,GO:0140096 2.3.2.6 ko:K00684 - - R03813,R11443,R11444 RC00055,RC00064 ko00000,ko01000 - - - Leu_Phe_trans k59_1531862_1 436308.Nmar_1509 1.06e-121 359.0 COG0608@1|root,arCOG00427@2157|Archaea,41SZF@651137|Thaumarchaeota 651137|Thaumarchaeota L DHHA1 domain - - - ko:K07463 - - - - ko00000 - - - DHHA1 k59_627659_1 1229909.NSED_07185 1.32e-93 280.0 COG0189@1|root,arCOG01589@2157|Archaea,41SE8@651137|Thaumarchaeota 651137|Thaumarchaeota H Lysine biosynthesis - - 6.3.2.43 ko:K05827 ko00300,ko01100,ko01210,ko01230,map00300,map01100,map01210,map01230 M00031 R09775 RC00064,RC00090 ko00000,ko00001,ko00002,ko01000 - - - RimK k59_1136016_1 640081.Dsui_1625 1.54e-92 298.0 COG2217@1|root,COG2608@1|root,COG2217@2|Bacteria,COG2608@2|Bacteria,1MU08@1224|Proteobacteria,2VJSM@28216|Betaproteobacteria,2KV1V@206389|Rhodocyclales 206389|Rhodocyclales P cation transport ATPase ccoI - 3.6.3.4 ko:K01533 - - R00086 RC00002 ko00000,ko01000 3.A.3.5 - - ATPase-cat_bd,E1-E2_ATPase,HMA,Hydrolase k59_6558_1 330214.NIDE3354 1.27e-34 127.0 COG0005@1|root,COG0005@2|Bacteria,3J0HC@40117|Nitrospirae 40117|Nitrospirae F Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates mtnP - 2.4.2.28 ko:K00772 ko00270,ko01100,map00270,map01100 M00034 R01402 RC00063,RC02819 ko00000,ko00001,ko00002,ko01000 - - - PNP_UDP_1 k59_6558_2 1232410.KI421424_gene1662 1.15e-28 110.0 COG0524@1|root,COG0524@2|Bacteria,1Q8Y3@1224|Proteobacteria,42NSV@68525|delta/epsilon subdivisions,2WJWD@28221|Deltaproteobacteria,43S1S@69541|Desulfuromonadales 28221|Deltaproteobacteria H PFAM PfkB domain protein - - - - - - - - - - - iAF987.Gmet_2683 PfkB k59_175753_1 1303518.CCALI_01889 2.04e-81 256.0 COG0017@1|root,COG0017@2|Bacteria 2|Bacteria J Asparaginyl-tRNA synthetase asnS GO:0000166,GO:0003674,GO:0003824,GO:0004812,GO:0004816,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006421,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.1.1.22 ko:K01893 ko00970,map00970 M00359,M00360 R03648 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iSDY_1059.SDY_2327 tRNA-synt_2,tRNA_anti-codon k59_1079420_1 2055.JNXA01000025_gene4129 4.6e-55 189.0 COG0028@1|root,COG0028@2|Bacteria,2GM6Y@201174|Actinobacteria,4GDMS@85026|Gordoniaceae 201174|Actinobacteria EH Thiamine pyrophosphate enzyme, central domain - - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_910205_2 745014.OMB55_00001780 8.29e-71 233.0 COG1529@1|root,COG1529@2|Bacteria,1QTTJ@1224|Proteobacteria,1RNCM@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL - - - - - - - - - - - - Ald_Xan_dh_C2 k59_966552_1 316407.1736473 5.7e-100 291.0 COG1956@1|root,COG1956@2|Bacteria,1RDBM@1224|Proteobacteria,1S6QU@1236|Gammaproteobacteria,3XN26@561|Escherichia 1236|Gammaproteobacteria T L-methionine-(R)-S-oxide reductase activity yebR GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0016491,GO:0016667,GO:0016671,GO:0033745,GO:0044424,GO:0044444,GO:0044464,GO:0055114 1.8.4.14 ko:K08968 ko00270,map00270 - R02025 RC00639 ko00000,ko00001,ko01000 - - - GAF_2 k59_966552_2 199310.c2242 5.11e-21 90.5 COG2995@1|root,COG2995@2|Bacteria,1MWG1@1224|Proteobacteria,1RM9Z@1236|Gammaproteobacteria,3XM56@561|Escherichia 1236|Gammaproteobacteria S response to heat yebS GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006950,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0071944 - ko:K03808 - - - - ko00000 - - - PqiA k59_854092_1 216432.CA2559_09473 1.66e-16 84.0 COG3291@1|root,COG4733@1|root,COG4886@1|root,COG3291@2|Bacteria,COG4733@2|Bacteria,COG4886@2|Bacteria,4NJHV@976|Bacteroidetes 976|Bacteroidetes L Fibronectin type 3 domain - - - - - - - - - - - - fn3 k59_740922_1 1132855.KB913035_gene1504 4.04e-73 243.0 COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,2VH8J@28216|Betaproteobacteria,2KMHU@206350|Nitrosomonadales 28216|Betaproteobacteria P ATPase, P-type (transporting), HAD superfamily, subfamily IC - - 3.6.3.54 ko:K17686 ko01524,ko04016,map01524,map04016 - R00086 RC00002 ko00000,ko00001,ko01000 3.A.3.5 - - E1-E2_ATPase,HMA,Hydrolase,YHS k59_1192744_1 1122137.AQXF01000001_gene2688 0.0 1039.0 COG1217@1|root,COG1217@2|Bacteria,1MV5Q@1224|Proteobacteria,2TR63@28211|Alphaproteobacteria 28211|Alphaproteobacteria T GTP-binding protein TypA typA GO:0000027,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006996,GO:0008150,GO:0009266,GO:0009408,GO:0009409,GO:0009628,GO:0009987,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0042254,GO:0042255,GO:0042273,GO:0043933,GO:0044085,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0065003,GO:0070925,GO:0071826,GO:0071840 - ko:K06207 - - - - ko00000 - - - EFG_C,GTP_EFTU,GTP_EFTU_D2 k59_119701_1 1454004.AW11_00956 2.9e-21 89.4 2C5P4@1|root,3310H@2|Bacteria,1P7TH@1224|Proteobacteria,2VZ2D@28216|Betaproteobacteria,1KR36@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_119701_2 1123355.JHYO01000009_gene3028 9.47e-16 75.5 COG1126@1|root,COG1126@2|Bacteria,1QXGG@1224|Proteobacteria 1224|Proteobacteria E ATPases associated with a variety of cellular activities - - - ko:K10000 ko02010,map02010 M00229 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.3.3 - - ABC_tran k59_1700942_1 1232449.BAHV02000001_gene269 6.77e-53 188.0 COG0085@1|root,COG0085@2|Bacteria,1TP96@1239|Firmicutes,247J1@186801|Clostridia,267SB@186813|unclassified Clostridiales 186801|Clostridia K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoB - 2.7.7.6 ko:K03043 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7 k59_1305968_1 316407.85675235 2.65e-129 383.0 COG4715@1|root,COG4715@2|Bacteria,1R7Q0@1224|Proteobacteria,1S927@1236|Gammaproteobacteria,3XNHR@561|Escherichia 1236|Gammaproteobacteria S SWIM zinc finger yehQ GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - - - - - - - - - - SWIM k59_6604_2 1128421.JAGA01000003_gene3718 2.82e-10 62.8 COG1132@1|root,COG1132@2|Bacteria,2NNVD@2323|unclassified Bacteria 2|Bacteria V ABC transporter msbA - - ko:K06147 - - - - ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran k59_1136047_2 1121378.KB899740_gene3807 0.000724 40.4 COG2801@1|root,COG2801@2|Bacteria 2|Bacteria L transposition - - - ko:K07497 - - - - ko00000 - - - HTH_21,rve,rve_2,rve_3 k59_1757545_1 1459636.NTE_00321 3.56e-35 122.0 arCOG11305@1|root,arCOG11305@2157|Archaea,41T7G@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1757545_2 1229909.NSED_03920 1.26e-226 629.0 COG0463@1|root,arCOG00894@2157|Archaea,41SAS@651137|Thaumarchaeota 651137|Thaumarchaeota M glycosyl transferase family 2 - - 2.4.1.83 ko:K00721 ko00510,ko01100,map00510,map01100 - R01009 RC00005 ko00000,ko00001,ko01000,ko01003 - GT2 - Glycos_transf_2,GtrA k59_966570_1 62928.azo0330 0.000328 44.3 COG0583@1|root,COG0583@2|Bacteria,1MWY0@1224|Proteobacteria,2VM3R@28216|Betaproteobacteria,2KYMI@206389|Rhodocyclales 206389|Rhodocyclales K LysR substrate binding domain - - - ko:K03566 ko02026,map02026 - - - ko00000,ko00001,ko03000 - - - HTH_1,LysR_substrate k59_1757547_1 436308.Nmar_1316 8.59e-51 171.0 COG0477@1|root,arCOG00130@2157|Archaea,41T0X@651137|Thaumarchaeota 651137|Thaumarchaeota G major facilitator superfamily - - - ko:K08153,ko:K08221 - M00717 - - ko00000,ko00002,ko02000 2.A.1.2.8,2.A.1.32 - - MFS_1 k59_1757547_2 1229909.NSED_07285 3.26e-45 151.0 COG2226@1|root,arCOG04348@2157|Archaea,41SGQ@651137|Thaumarchaeota 651137|Thaumarchaeota Q ubiE/COQ5 methyltransferase family - - 2.1.1.163,2.1.1.201 ko:K03183 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116,M00117 R04990,R04993,R06859,R08774,R09736 RC00003,RC01253,RC01662 ko00000,ko00001,ko00002,ko01000 - - - Ubie_methyltran k59_289288_1 589865.DaAHT2_1782 8.4e-38 142.0 COG5002@1|root,COG5278@1|root,COG5002@2|Bacteria,COG5278@2|Bacteria,1R5EN@1224|Proteobacteria,43D5Y@68525|delta/epsilon subdivisions,2X8CR@28221|Deltaproteobacteria 28221|Deltaproteobacteria T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA k59_345760_1 1121937.AUHJ01000010_gene1750 1.58e-87 266.0 COG0656@1|root,COG0656@2|Bacteria,1MX6S@1224|Proteobacteria,1RQA1@1236|Gammaproteobacteria,466RA@72275|Alteromonadaceae 1236|Gammaproteobacteria S COG0656 Aldo keto reductases, related to diketogulonate reductase - - - - - - - - - - - - Aldo_ket_red k59_1644990_2 1123072.AUDH01000008_gene264 1.97e-48 162.0 COG0684@1|root,COG0684@2|Bacteria,1MUES@1224|Proteobacteria,2U0IC@28211|Alphaproteobacteria 28211|Alphaproteobacteria H Demethylmenaquinone methyltransferase MA20_26380 - - - - - - - - - - - RraA-like k59_860609_2 1229909.NSED_08965 7.59e-70 212.0 COG0864@1|root,arCOG01008@2157|Archaea,41SQM@651137|Thaumarchaeota 651137|Thaumarchaeota K Ribbon-helix-helix protein, copG family - - - ko:K07722 - - - - ko00000,ko03000 - - - NikR_C,RHH_1 k59_351783_1 565045.NOR51B_2632 4.57e-128 380.0 COG0591@1|root,COG0591@2|Bacteria,1R4VK@1224|Proteobacteria,1RQFS@1236|Gammaproteobacteria,1JBZB@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family nanT - - ko:K03307 - - - - ko00000 2.A.21 - - SSF k59_577226_1 745310.G432_03905 1.73e-46 162.0 COG1752@1|root,COG1752@2|Bacteria,1MVHW@1224|Proteobacteria,2TS4V@28211|Alphaproteobacteria,2K15U@204457|Sphingomonadales 204457|Sphingomonadales S esterase of the alpha-beta hydrolase superfamily - - - ko:K07001 - - - - ko00000 - - - DUF3734,Patatin k59_1255130_1 953739.SVEN_0119 2.63e-66 214.0 COG0604@1|root,COG0604@2|Bacteria,2GIS3@201174|Actinobacteria 201174|Actinobacteria C alcohol dehydrogenase - - - - - - - - - - - - ADH_N,ADH_zinc_N_2 k59_1650831_1 1122137.AQXF01000003_gene2184 2.12e-43 159.0 2CZCR@1|root,32T63@2|Bacteria,1N2RG@1224|Proteobacteria,2UDG9@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_1650831_2 1122137.AQXF01000003_gene2185 1.6e-28 108.0 COG0455@1|root,COG0455@2|Bacteria,1R8IW@1224|Proteobacteria,2TWWA@28211|Alphaproteobacteria 28211|Alphaproteobacteria D Belongs to the ParA family - - - ko:K04562 - - - - ko00000,ko02035 - - - AAA_31,CbiA,ParA k59_746345_1 1122137.AQXF01000002_gene310 1.4e-138 410.0 COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,2TQRZ@28211|Alphaproteobacteria 28211|Alphaproteobacteria S COG0488 ATPase components of ABC transporters with duplicated ATPase domains yheS GO:0000166,GO:0003674,GO:0005488,GO:0005524,GO:0008144,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - ko:K06158 - - - - ko00000,ko03012 - - - ABC_tran,ABC_tran_CTD,ABC_tran_Xtn k59_1312133_1 1211813.CAPH01000012_gene327 4.24e-90 276.0 COG0015@1|root,COG0015@2|Bacteria,4NFY8@976|Bacteroidetes,2FMYF@200643|Bacteroidia,22UZK@171550|Rikenellaceae 976|Bacteroidetes F Adenylosuccinate lyase C-terminal purB - 4.3.2.2 ko:K01756 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048,M00049 R01083,R04559 RC00379,RC00444,RC00445 ko00000,ko00001,ko00002,ko01000 - - - ADSL_C,ASL_C,Lyase_1 k59_803764_1 84531.JMTZ01000062_gene1995 3.85e-60 209.0 COG4953@1|root,COG4953@2|Bacteria,1MUA9@1224|Proteobacteria,1RMBV@1236|Gammaproteobacteria,1X4XC@135614|Xanthomonadales 135614|Xanthomonadales M penicillin-binding protein - - 2.4.1.129 ko:K05367 ko00550,map00550 - - - ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 - BiPBP_C,Transgly,Transpeptidase k59_1594067_1 553217.ENHAE0001_2020 3.61e-38 138.0 COG0730@1|root,COG0730@2|Bacteria,1RD5A@1224|Proteobacteria,1S6M1@1236|Gammaproteobacteria 1236|Gammaproteobacteria S membrane transporter protein - - - - - - - - - - - - TauE k59_803771_1 1056820.KB900650_gene2906 2.51e-17 79.3 COG2755@1|root,COG2755@2|Bacteria,1MVYS@1224|Proteobacteria,1S0VK@1236|Gammaproteobacteria,2PMKA@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria E GDSL-like Lipase/Acylhydrolase rhgT - - - - - - - - - - - Cupin_2,Lipase_GDSL_2 k59_803771_2 1286106.MPL1_12346 8.55e-41 139.0 COG0454@1|root,COG0456@2|Bacteria,1RKJA@1224|Proteobacteria,1T1ZP@1236|Gammaproteobacteria,462JP@72273|Thiotrichales 72273|Thiotrichales K Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_10 k59_125558_1 247633.GP2143_04173 2.06e-58 199.0 COG2234@1|root,COG2234@2|Bacteria 2|Bacteria DZ aminopeptidase activity - - - - - - - - - - - - PA,Peptidase_M28 k59_1424255_1 118163.Ple7327_3118 4.73e-17 81.6 COG0520@1|root,COG0520@2|Bacteria,1G4XH@1117|Cyanobacteria,3VHS8@52604|Pleurocapsales 1117|Cyanobacteria E Cysteine desulfurase family protein, VC1184 subfamily - - - - - - - - - - - - Aminotran_5 k59_1424255_2 935261.JAGL01000030_gene300 6.91e-164 473.0 COG2235@1|root,COG2235@2|Bacteria,1NCGV@1224|Proteobacteria,2TU0Z@28211|Alphaproteobacteria,43GUQ@69277|Phyllobacteriaceae 28211|Alphaproteobacteria E Arginine arcA - 3.5.3.6 ko:K01478 ko00220,ko01100,ko01110,ko01130,map00220,map01100,map01110,map01130 - R00552 RC00177 ko00000,ko00001,ko01000 - - - Amidinotransf k59_520245_1 436308.Nmar_1390 5.38e-108 317.0 COG0167@1|root,arCOG00603@2157|Archaea 2157|Archaea F Catalyzes the conversion of dihydroorotate to orotate pyrD GO:0003674,GO:0003824,GO:0004152,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006206,GO:0006207,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009987,GO:0016491,GO:0016627,GO:0016635,GO:0018130,GO:0019856,GO:0034641,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046112,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 1.3.1.1,1.3.1.14,1.3.5.2,1.3.98.1 ko:K00226,ko:K00254,ko:K17723,ko:K17828 ko00240,ko00410,ko00770,ko01100,map00240,map00410,map00770,map01100 M00046,M00051 R00977,R01414,R01867,R01868,R01869,R11026 RC00051,RC00072,RC00123 ko00000,ko00001,ko00002,ko01000 - - - DHO_dh k59_860638_1 243233.MCA1306 8.65e-44 163.0 COG0443@1|root,COG0443@2|Bacteria,1MXX7@1224|Proteobacteria,1RP0D@1236|Gammaproteobacteria,1XE04@135618|Methylococcales 135618|Methylococcales O Belongs to the heat shock protein 70 family - - - - - - - - - - - - DUF3731,HSP70 k59_1763570_1 1168289.AJKI01000021_gene1776 1.21e-112 336.0 COG3693@1|root,COG3693@2|Bacteria,4NE5Z@976|Bacteroidetes,2G2PS@200643|Bacteroidia,3XJBG@558415|Marinilabiliaceae 976|Bacteroidetes G Glycosyl hydrolase family 10 - - - - - - - - - - - - Glyco_hydro_10 k59_971978_1 1279017.AQYJ01000022_gene2663 4.7e-41 142.0 COG0217@1|root,COG0217@2|Bacteria,1MW3X@1224|Proteobacteria,1RP5N@1236|Gammaproteobacteria,465EW@72275|Alteromonadaceae 1236|Gammaproteobacteria K transcriptional regulatory protein yebC GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0009314,GO:0009628,GO:0010212,GO:0044424,GO:0044444,GO:0044464,GO:0050896 - - - - - - - - - - Transcrip_reg k59_352902_1 1042377.AFPJ01000009_gene292 1.23e-91 281.0 COG1448@1|root,COG1448@2|Bacteria,1MUT0@1224|Proteobacteria,1RN02@1236|Gammaproteobacteria,4647G@72275|Alteromonadaceae 1236|Gammaproteobacteria E COG1448 Aspartate tyrosine aromatic aminotransferase aspC - 2.6.1.1,2.6.1.57 ko:K00813,ko:K00832 ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230 M00024,M00025,M00034,M00040 R00355,R00694,R00734,R00896,R01731,R02433,R02619,R05052,R07396,R10845 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 k59_296433_1 394221.Mmar10_3012 3.14e-41 150.0 COG0683@1|root,COG0683@2|Bacteria,1QURG@1224|Proteobacteria,2TS62@28211|Alphaproteobacteria,4414W@69657|Hyphomonadaceae 28211|Alphaproteobacteria E Periplasmic binding protein MA20_24635 - - - - - - - - - - - Peripla_BP_6 k59_861877_1 1089548.KI783301_gene489 8.83e-45 159.0 COG0183@1|root,COG0183@2|Bacteria,1TP07@1239|Firmicutes,4H9RJ@91061|Bacilli,3WEJS@539002|Bacillales incertae sedis 91061|Bacilli I Belongs to the thiolase family atoB - 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N k59_691205_1 351607.Acel_1934 1.04e-60 199.0 COG0399@1|root,COG0399@2|Bacteria,2GKD7@201174|Actinobacteria,4EUKI@85013|Frankiales 201174|Actinobacteria E DegT/DnrJ/EryC1/StrS aminotransferase family degT - - - - - - - - - - - DegT_DnrJ_EryC1 k59_126732_1 1469557.JSWF01000024_gene1803 4.72e-71 225.0 COG2972@1|root,COG2972@2|Bacteria,4NH1Q@976|Bacteroidetes,1HXVP@117743|Flavobacteriia 976|Bacteroidetes T Histidine kinase - - - - - - - - - - - - HATPase_c_5,His_kinase k59_13743_1 1209072.ALBT01000044_gene2534 1.83e-131 391.0 COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,1RMNZ@1236|Gammaproteobacteria,1FH2P@10|Cellvibrio 1236|Gammaproteobacteria H Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA acsA - 6.2.1.1 ko:K01895 ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200 M00357 R00235,R00236,R00316,R00926,R01354 RC00004,RC00012,RC00043,RC00070,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000,ko01004 - - - ACAS_N,AMP-binding,AMP-binding_C k59_747469_1 1122137.AQXF01000003_gene2177 1.52e-155 439.0 COG1352@1|root,COG1352@2|Bacteria,1MU6W@1224|Proteobacteria,2TRQ3@28211|Alphaproteobacteria 28211|Alphaproteobacteria NT Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP cheR - 2.1.1.80 ko:K00575 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko01000,ko02035 - - - CheR,CheR_N k59_747469_2 1122137.AQXF01000003_gene2176 2.3e-40 144.0 COG2201@1|root,COG2201@2|Bacteria,1MWCN@1224|Proteobacteria,2TSGV@28211|Alphaproteobacteria 28211|Alphaproteobacteria NT catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR cheB - 3.1.1.61,3.5.1.44 ko:K03412 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko02022,ko02035 - - - CheB_methylest,Response_reg k59_239021_1 396588.Tgr7_2024 1.85e-114 349.0 COG0272@1|root,COG0272@2|Bacteria,1MV3R@1224|Proteobacteria,1RPAV@1236|Gammaproteobacteria,1WX4B@135613|Chromatiales 135613|Chromatiales L DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA ligA - 6.5.1.2 ko:K01972 ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430 - R00382 RC00005 ko00000,ko00001,ko01000,ko03032,ko03400 - - - BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5 k59_1707833_1 1415166.NONO_c30950 6.03e-72 236.0 COG2072@1|root,COG2072@2|Bacteria,2GKYU@201174|Actinobacteria,4FW1H@85025|Nocardiaceae 201174|Actinobacteria P Flavin-binding monooxygenase-like pamO - 1.14.13.22,1.14.13.92 ko:K03379,ko:K18229 ko00930,ko01120,ko01220,map00930,map01120,map01220 - R02231,R06622 RC00662,RC01550 ko00000,ko00001,ko01000 - - - Abhydrolase_3,FMO-like,Pyr_redox_2,Pyr_redox_3 k59_465175_1 1304865.JAGF01000001_gene2475 4.43e-05 47.8 COG5001@1|root,COG5001@2|Bacteria,2GIZF@201174|Actinobacteria 201174|Actinobacteria T signal transduction protein containing a membrane domain an EAL and a GGDEF domain - - - - - - - - - - - - EAL,GGDEF k59_747479_1 886293.Sinac_0959 7.52e-59 192.0 COG0176@1|root,COG0176@2|Bacteria,2IYC8@203682|Planctomycetes 203682|Planctomycetes H Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway - - 2.2.1.2 ko:K00616 ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007 R01827 RC00439,RC00604 ko00000,ko00001,ko00002,ko01000 - - - TAL_FSA k59_972892_2 1137269.AZWL01000003_gene1590 2.32e-06 49.3 COG1028@1|root,COG1028@2|Bacteria,2GIX2@201174|Actinobacteria 201174|Actinobacteria IQ Short-chain dehydrogenase reductase sdr - - 1.1.1.100 ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 k59_465176_1 158500.BV97_01456 2.57e-91 279.0 COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,2TS1R@28211|Alphaproteobacteria,2JZW6@204457|Sphingomonadales 204457|Sphingomonadales I Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation - - 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N k59_1086554_1 316407.85675871 2.85e-57 182.0 COG1695@1|root,COG1695@2|Bacteria,1RHSE@1224|Proteobacteria,1S255@1236|Gammaproteobacteria,3XNX9@561|Escherichia 1236|Gammaproteobacteria K transcriptional regulator yqjI GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0006950,GO:0006974,GO:0008150,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0033554,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0051716,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:2000112,GO:2000113,GO:2001141 - - - - - - - - - - PadR k59_917270_1 436308.Nmar_1782 1.03e-30 119.0 COG1746@1|root,arCOG04249@2157|Archaea,41S76@651137|Thaumarchaeota 651137|Thaumarchaeota J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate cca - 2.7.7.72 ko:K07558 - - R09382,R09383,R09384,R09386 RC00078 ko00000,ko01000,ko03016 - - - NTP_transf_2,tRNA_NucTransf2 k59_917270_2 1131266.ARWQ01000001_gene1353 1.96e-19 84.3 COG1514@1|root,arCOG01736@2157|Archaea,41SP7@651137|Thaumarchaeota 651137|Thaumarchaeota J Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester - - 3.1.4.58 ko:K01975 - - - - ko00000,ko01000,ko03016 - - - LigT_PEase k59_1707853_1 269797.Mbar_A3073 7.08e-24 99.8 COG3119@1|root,arCOG02791@2157|Archaea,2Y8G8@28890|Euryarchaeota,2NAEA@224756|Methanomicrobia 224756|Methanomicrobia P Sulfatase - - 3.1.6.1 ko:K01130 ko00140,ko00600,map00140,map00600 - R03980,R04856 RC00128,RC00231 ko00000,ko00001,ko01000 - - - Sulfatase k59_1707853_2 85643.Tmz1t_1479 5.14e-79 246.0 COG0641@1|root,COG0641@2|Bacteria,1MX3M@1224|Proteobacteria,2VY2Q@28216|Betaproteobacteria,2KXWX@206389|Rhodocyclales 206389|Rhodocyclales C Iron-sulfur cluster-binding domain - - - ko:K06871 - - - - ko00000 - - - Radical_SAM,SPASM k59_1313312_1 298655.KI912266_gene337 2.08e-09 60.8 COG0085@1|root,COG0085@2|Bacteria,2GJ81@201174|Actinobacteria,4ES8S@85013|Frankiales 201174|Actinobacteria K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoB GO:0000428,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0030880,GO:0032991,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0061695,GO:0071944,GO:1902494,GO:1990234 2.7.7.6 ko:K03043 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7 k59_804812_1 1082933.MEA186_05671 1.55e-06 48.9 COG0659@1|root,COG0659@2|Bacteria,1MVWV@1224|Proteobacteria,2TUH6@28211|Alphaproteobacteria,43IQK@69277|Phyllobacteriaceae 28211|Alphaproteobacteria P Sulfate transporter MA20_05210 - - ko:K03321 - - - - ko00000,ko02000 2.A.53.3 - - STAS,Sulfate_transp k59_804812_2 670307.HYPDE_24233 8.14e-31 110.0 COG1396@1|root,COG1396@2|Bacteria,1MZQK@1224|Proteobacteria,2UCAK@28211|Alphaproteobacteria,3N8Z3@45401|Hyphomicrobiaceae 28211|Alphaproteobacteria K Helix-turn-helix XRE-family like proteins MA20_05215 - - - - - - - - - - - HTH_3,HTH_31 k59_804812_3 247634.GPB2148_813 2.51e-06 49.3 COG1231@1|root,COG1231@2|Bacteria,1QXX6@1224|Proteobacteria,1T3IZ@1236|Gammaproteobacteria,1J5KT@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E K COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit - - 1.5.99.6 ko:K00316 ko00330,ko00410,ko01100,map00330,map00410,map01100 - R01914,R01915 RC00053,RC00225 ko00000,ko00001,ko01000 - - - NAD_binding_8 k59_804813_1 1096930.L284_22155 9.97e-27 106.0 COG1234@1|root,COG1234@2|Bacteria,1R64Z@1224|Proteobacteria,2TU6T@28211|Alphaproteobacteria,2K63Y@204457|Sphingomonadales 204457|Sphingomonadales S Beta-lactamase superfamily domain - - - - - - - - - - - - Lactamase_B_2 k59_1143021_1 204773.HEAR1466 3.98e-37 135.0 COG1638@1|root,COG1638@2|Bacteria,1MWAW@1224|Proteobacteria,2VJB5@28216|Betaproteobacteria,472A1@75682|Oxalobacteraceae 28216|Betaproteobacteria G TRAP-type C4-dicarboxylate transport system, periplasmic component - - - - - - - - - - - - DctP k59_1143021_2 1386969.AWTB01000103_gene3681 1.6e-07 53.5 COG0318@1|root,COG0318@2|Bacteria,2GIUC@201174|Actinobacteria,4GBU2@85026|Gordoniaceae 201174|Actinobacteria IQ AMP-binding enzyme C-terminal domain fadD - 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding,AMP-binding_C k59_747505_1 158500.BV97_05047 1.82e-53 192.0 COG3250@1|root,COG3250@2|Bacteria,1P9KJ@1224|Proteobacteria,2UZ0A@28211|Alphaproteobacteria,2K315@204457|Sphingomonadales 204457|Sphingomonadales G alpha-L-rhamnosidase - - - - - - - - - - - - Glyco_hydro_106 k59_1086578_1 436308.Nmar_0849 9.11e-49 164.0 arCOG08708@1|root,arCOG08708@2157|Archaea,41SPK@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_634749_1 768671.ThimaDRAFT_0197 1.21e-21 97.4 COG0834@1|root,COG4585@1|root,COG0834@2|Bacteria,COG4585@2|Bacteria,1N315@1224|Proteobacteria,1T3XJ@1236|Gammaproteobacteria 1236|Gammaproteobacteria ET Bacterial extracellular solute-binding proteins, family 3 - - - - - - - - - - - - SBP_bac_3 k59_634749_2 996637.SGM_4787 1.35e-19 86.3 COG2197@1|root,COG2197@2|Bacteria,2GNAU@201174|Actinobacteria 201174|Actinobacteria T response regulator - - - - - - - - - - - - GerE,Response_reg k59_1369860_1 1121413.JMKT01000009_gene1936 2.28e-91 276.0 COG0668@1|root,COG0668@2|Bacteria,1N596@1224|Proteobacteria,42M0U@68525|delta/epsilon subdivisions,2WJR5@28221|Deltaproteobacteria,2MAEE@213115|Desulfovibrionales 28221|Deltaproteobacteria M mechanosensitive ion channel - - - ko:K03442 - - - - ko00000,ko02000 1.A.23.2 - - LysM,MS_channel,TM_helix k59_1425441_1 644966.Tmar_1982 8.69e-36 137.0 COG0477@1|root,COG0477@2|Bacteria,COG2814@2|Bacteria,1TPHW@1239|Firmicutes 1239|Firmicutes P Major facilitator superfamily - - - - - - - - - - - - MFS_1 k59_1256189_1 7425.NV15455-PA 3.02e-25 105.0 COG2303@1|root,KOG1238@2759|Eukaryota,38UEK@33154|Opisthokonta,3BMXI@33208|Metazoa,3CZU0@33213|Bilateria,41UDX@6656|Arthropoda,3SFUR@50557|Insecta,46KRF@7399|Hymenoptera 33208|Metazoa E GMC oxidoreductase - GO:0002165,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0006629,GO:0007275,GO:0008150,GO:0008152,GO:0008202,GO:0009791,GO:0009987,GO:0010817,GO:0016491,GO:0030312,GO:0032501,GO:0032502,GO:0034754,GO:0042180,GO:0042445,GO:0042600,GO:0044237,GO:0044238,GO:0044281,GO:0044464,GO:0045455,GO:0048856,GO:0055114,GO:0065007,GO:0065008,GO:0071704,GO:0071944,GO:1901360 1.1.3.49,1.1.5.9 ko:K00115,ko:K21270 ko00030,ko01100,ko01110,ko01130,map00030,map01100,map01110,map01130 - R00305 RC00066 ko00000,ko00001,ko01000 - - - GMC_oxred_C,GMC_oxred_N k59_1256189_2 395493.BegalDRAFT_2091 1.68e-31 123.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria 1236|Gammaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K18989 - M00720 - - ko00000,ko00002,ko02000 2.A.6.2.30 - - ACR_tran k59_1199896_1 1453501.JELR01000001_gene2967 5.98e-117 345.0 COG1702@1|root,COG1702@2|Bacteria,1MVDV@1224|Proteobacteria,1RP2Y@1236|Gammaproteobacteria,464W4@72275|Alteromonadaceae 1236|Gammaproteobacteria T COG1702 Phosphate starvation-inducible protein PhoH ybeZ GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - ko:K06217 - - - - ko00000 - - - PhoH k59_126816_2 861299.J421_3380 1.65e-58 200.0 COG0046@1|root,COG0046@2|Bacteria,1ZT8W@142182|Gemmatimonadetes 142182|Gemmatimonadetes F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL purL - 6.3.5.3 ko:K01952 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04463 RC00010,RC01160 ko00000,ko00001,ko00002,ko01000 - - - AIRS,AIRS_C k59_917291_1 452662.SJA_C2-01170 4.78e-46 176.0 COG4773@1|root,COG4773@2|Bacteria,1QTXJ@1224|Proteobacteria,2U2G4@28211|Alphaproteobacteria,2KEBD@204457|Sphingomonadales 204457|Sphingomonadales P PFAM TonB-dependent Receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_1707911_1 666509.RCA23_c28360 5.15e-108 326.0 COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,2TR4Q@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Protein conserved in bacteria - - - ko:K07793 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.80.1 - - TctA k59_1199903_1 493475.GARC_2868 2.01e-28 118.0 COG4770@1|root,COG4770@2|Bacteria,1P6RE@1224|Proteobacteria,1RM95@1236|Gammaproteobacteria,465G3@72275|Alteromonadaceae 1236|Gammaproteobacteria I COG4770 Acetyl propionyl-CoA carboxylase, alpha subunit mccA - 6.4.1.4 ko:K01968 ko00280,ko01100,map00280,map01100 M00036 R04138 RC00367,RC00942 ko00000,ko00001,ko00002,ko01000 - - - Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2 k59_13821_1 685727.REQ_01060 1.52e-76 254.0 COG2272@1|root,COG2272@2|Bacteria,2GJCN@201174|Actinobacteria,4G07C@85025|Nocardiaceae 201174|Actinobacteria I Carboxylesterase family - - - ko:K03929 - - - - ko00000,ko01000 - CE10 - COesterase k59_1369891_1 1232683.ADIMK_3843 3.61e-15 80.9 COG2114@1|root,COG4252@1|root,COG2114@2|Bacteria,COG4252@2|Bacteria,1MV1V@1224|Proteobacteria,1RYBQ@1236|Gammaproteobacteria,4662J@72275|Alteromonadaceae 1236|Gammaproteobacteria T CHASE2 - - 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 - - - CHASE2,Guanylate_cyc k59_353004_1 194439.CT1021 1.6e-130 389.0 COG0737@1|root,COG0737@2|Bacteria,1FEND@1090|Chlorobi 1090|Chlorobi F Belongs to the 5'-nucleotidase family - - - ko:K17224 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00595 R10151 RC03151,RC03152 ko00000,ko00001,ko00002 - - - 5_nucleotid_C k59_1764737_1 1121012.AUKX01000010_gene1959 5.58e-07 57.0 COG1629@1|root,COG1629@2|Bacteria,4NQ0X@976|Bacteroidetes 976|Bacteroidetes P CarboxypepD_reg-like domain - - - - - - - - - - - - CarbopepD_reg_2 k59_465242_1 76114.ebA6468 3.12e-60 190.0 COG1047@1|root,COG1047@2|Bacteria,1RD35@1224|Proteobacteria,2VQA2@28216|Betaproteobacteria,2KW5U@206389|Rhodocyclales 206389|Rhodocyclales O FKBP-type peptidyl-prolyl cis-trans slyD - 5.2.1.8 ko:K03775 - - - - ko00000,ko01000,ko03110 - - - FKBP_C k59_70714_2 251229.Chro_2396 1.6e-35 129.0 COG0607@1|root,COG0607@2|Bacteria,1G8N9@1117|Cyanobacteria 1117|Cyanobacteria P PFAM Rhodanese-like domain - - - - - - - - - - - - Rhodanese k59_747537_1 1280953.HOC_09389 1.99e-81 248.0 COG1024@1|root,COG1024@2|Bacteria,1MVQN@1224|Proteobacteria,2UNSV@28211|Alphaproteobacteria,43ZQ0@69657|Hyphomonadaceae 28211|Alphaproteobacteria I Enoyl-CoA hydratase isomerase family protein - - - - - - - - - - - - ECH_1 k59_13842_1 1168065.DOK_18020 3.51e-61 202.0 COG1207@1|root,COG1207@2|Bacteria,1MUPH@1224|Proteobacteria,1RNKE@1236|Gammaproteobacteria,1J4PN@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain glmU GO:0000270,GO:0000271,GO:0000287,GO:0003674,GO:0003824,GO:0003977,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0006022,GO:0006023,GO:0006024,GO:0006040,GO:0006047,GO:0006048,GO:0006139,GO:0006629,GO:0006725,GO:0006793,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009225,GO:0009226,GO:0009252,GO:0009273,GO:0009987,GO:0016051,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0016772,GO:0016779,GO:0018130,GO:0019134,GO:0019438,GO:0030203,GO:0033692,GO:0034637,GO:0034641,GO:0034645,GO:0034654,GO:0042546,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046349,GO:0046483,GO:0046872,GO:0055086,GO:0070569,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1903509 2.3.1.157,2.7.7.23 ko:K04042 ko00520,ko01100,ko01130,map00520,map01100,map01130 M00362 R00416,R05332 RC00002,RC00004,RC00166 ko00000,ko00001,ko00002,ko01000 - - iECED1_1282.ECED1_4420,iYL1228.KPN_04135 Hexapep,Hexapep_2,NTP_transf_3 k59_408885_1 1122137.AQXF01000002_gene590 7.77e-104 319.0 COG0471@1|root,COG0490@1|root,COG0471@2|Bacteria,COG0490@2|Bacteria,1MU0K@1224|Proteobacteria,2TSFS@28211|Alphaproteobacteria 28211|Alphaproteobacteria P COG0471 Di- and tricarboxylate transporters - - - - - - - - - - - - CitMHS,TrkA_C k59_408885_2 1122137.AQXF01000002_gene589 1.01e-74 231.0 COG1360@1|root,COG1360@2|Bacteria,1MW1Y@1224|Proteobacteria,2TTW2@28211|Alphaproteobacteria 28211|Alphaproteobacteria N flagellar motor protein motB - - ko:K02557 ko02030,ko02040,map02030,map02040 - - - ko00000,ko00001,ko02000,ko02035 1.A.30.1 - - MotB_plug,OmpA k59_126844_1 985867.AEWF01000005_gene2487 8.66e-14 71.6 COG0643@1|root,COG0643@2|Bacteria,1MUAG@1224|Proteobacteria,2TSN2@28211|Alphaproteobacteria,47G1C@766|Rickettsiales 766|Rickettsiales NT Signal transducing histidine kinase, homodimeric domain - - 2.7.13.3 ko:K03407 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 - - - CheW,H-kinase_dim,HATPase_c,Hpt k59_126844_2 658086.HMPREF0994_02978 1.5e-09 63.9 COG0745@1|root,COG0745@2|Bacteria,1TPZ0@1239|Firmicutes,2484X@186801|Clostridia,27J18@186928|unclassified Lachnospiraceae 186801|Clostridia T Transcriptional regulatory protein, C terminal srrA_6 - - - - - - - - - - - Response_reg,Trans_reg_C k59_634800_1 351016.RAZWK3B_10692 4.15e-52 171.0 COG4976@1|root,COG4976@2|Bacteria,1RJBE@1224|Proteobacteria,2U9XU@28211|Alphaproteobacteria,2P3FY@2433|Roseobacter 28211|Alphaproteobacteria S Methyltransferase domain - - - - - - - - - - - - Methyltransf_11,Methyltransf_25 k59_521334_1 316407.85676817 1.85e-102 311.0 COG0025@1|root,COG0025@2|Bacteria,1MW5T@1224|Proteobacteria,1RPH6@1236|Gammaproteobacteria,3XN4E@561|Escherichia 1236|Gammaproteobacteria P sodium ion import across plasma membrane yjcE GO:0003674,GO:0005215,GO:0005451,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0006814,GO:0006873,GO:0006885,GO:0008150,GO:0008324,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015079,GO:0015081,GO:0015291,GO:0015297,GO:0015298,GO:0015299,GO:0015318,GO:0015385,GO:0015386,GO:0015491,GO:0015672,GO:0016020,GO:0019725,GO:0022804,GO:0022821,GO:0022857,GO:0022890,GO:0030001,GO:0030003,GO:0030004,GO:0030641,GO:0034220,GO:0035725,GO:0042592,GO:0044464,GO:0046873,GO:0048878,GO:0050801,GO:0051179,GO:0051234,GO:0051453,GO:0055067,GO:0055080,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0071804,GO:0071805,GO:0071944,GO:0098655,GO:0098657,GO:0098659,GO:0098660,GO:0098662,GO:0098719,GO:0098739,GO:0098771,GO:0099516,GO:0099587,GO:1902600 - ko:K03316 - - - - ko00000 2.A.36 - - Na_H_Exchanger k59_13849_1 189425.PGRAT_04730 2.09e-21 98.2 COG0383@1|root,COG0383@2|Bacteria,1TQEH@1239|Firmicutes,4HB2V@91061|Bacilli,26SFU@186822|Paenibacillaceae 91061|Bacilli G Alpha-mannosidase - - 3.2.1.24 ko:K01191 ko00511,map00511 - - - ko00000,ko00001,ko01000,ko04131 - GH38 - Alpha-mann_mid,Glyco_hydro_38,Glyco_hydro_38C k59_408891_2 105559.Nwat_0184 2.65e-56 176.0 COG1146@1|root,COG1146@2|Bacteria,1RH5I@1224|Proteobacteria,1S5ZK@1236|Gammaproteobacteria,1WYW2@135613|Chromatiales 135613|Chromatiales C Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions - - - ko:K05524 - - - - ko00000 - - - DUF3470,Fer4 k59_1764747_1 1088721.NSU_3965 6.72e-30 119.0 COG4784@1|root,COG4784@2|Bacteria,1QTT7@1224|Proteobacteria,2TTU7@28211|Alphaproteobacteria,2K1IX@204457|Sphingomonadales 204457|Sphingomonadales S peptidase M48, Ste24p - - - - - - - - - - - - LysM,Peptidase_M48 k59_1764747_2 702113.PP1Y_AT29597 5.94e-68 214.0 COG4974@1|root,COG4974@2|Bacteria,1MVNF@1224|Proteobacteria,2TRAA@28211|Alphaproteobacteria,2K25K@204457|Sphingomonadales 204457|Sphingomonadales L Belongs to the 'phage' integrase family xerC - - ko:K04763 - - - - ko00000,ko03036 - - - Phage_int_SAM_1,Phage_integrase k59_1425499_1 1415778.JQMM01000001_gene131 1.97e-44 150.0 COG3279@1|root,COG3279@2|Bacteria,1MUE8@1224|Proteobacteria,1RMJJ@1236|Gammaproteobacteria,1J5Z0@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria K Response regulator of the LytR AlgR family algR - - ko:K08083 ko02020,map02020 M00493 - - ko00000,ko00001,ko00002,ko02022 - - - LytTR,Response_reg k59_1425499_2 1415778.JQMM01000001_gene132 4.95e-28 111.0 COG2972@1|root,COG2972@2|Bacteria,1MXVQ@1224|Proteobacteria,1RQDA@1236|Gammaproteobacteria,1J5V1@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T signal transduction protein with a C-terminal ATPase domain algZ - 2.7.13.3 ko:K08082 ko02020,map02020 M00493 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - His_kinase k59_70719_1 1120792.JAFV01000001_gene3487 1.91e-05 50.1 COG0507@1|root,COG0507@2|Bacteria,1MW43@1224|Proteobacteria,2TQWC@28211|Alphaproteobacteria,36XBP@31993|Methylocystaceae 28211|Alphaproteobacteria L PIF1-like helicase - - 3.1.11.5 ko:K01144 - - - - ko00000,ko01000 - - - AAA_30,UvrD_C_2 k59_70719_3 1121129.KB903359_gene1822 1.09e-19 89.4 COG0847@1|root,COG0847@2|Bacteria,4NP7B@976|Bacteroidetes,2FSMF@200643|Bacteroidia,22Y26@171551|Porphyromonadaceae 976|Bacteroidetes L Exonuclease - - 2.7.7.7 ko:K02342 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - RNase_T k59_1425502_1 305700.B447_00345 1.03e-72 227.0 COG1806@1|root,COG1806@2|Bacteria,1MUHU@1224|Proteobacteria,2VI4R@28216|Betaproteobacteria,2KVFV@206389|Rhodocyclales 206389|Rhodocyclales F Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the phosphoenolpyruvate synthase (PEPS) by catalyzing its phosphorylation dephosphorylation - - 2.7.11.33,2.7.4.28 ko:K09773 - - - - ko00000,ko01000 - - - Kinase-PPPase k59_578362_1 94624.Bpet4350 1.05e-118 350.0 COG0075@1|root,COG0075@2|Bacteria,1MWHJ@1224|Proteobacteria,2VI9Q@28216|Betaproteobacteria,3T51C@506|Alcaligenaceae 28216|Betaproteobacteria E Serine-pyruvate aminotransferase archaeal aspartate aminotransferase sgaA - 2.6.1.44,2.6.1.45,2.6.1.51 ko:K00830 ko00250,ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko04146,map00250,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200,map04146 M00346,M00532 R00369,R00372,R00585,R00588 RC00006,RC00008,RC00018 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_5 k59_70727_1 1120953.AUBH01000009_gene47 1.18e-10 65.9 2ECN7@1|root,336K3@2|Bacteria,1NV01@1224|Proteobacteria,1SRBC@1236|Gammaproteobacteria,46BJK@72275|Alteromonadaceae 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_353040_1 83406.HDN1F_28540 8.47e-48 162.0 COG1277@1|root,COG1277@2|Bacteria,1NZZ9@1224|Proteobacteria,1RP6C@1236|Gammaproteobacteria,1J4KF@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria N ABC-type uncharacterized transport system - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_2,ABC2_membrane_3,ABC_transp_aux k59_1707968_1 457425.XNR_3106 7.86e-17 79.3 COG2910@1|root,COG2910@2|Bacteria,2GK2P@201174|Actinobacteria 201174|Actinobacteria S NADH-flavin reductase - - - ko:K07118 - - - - ko00000 - - - NAD_binding_10 k59_1707968_2 595460.RRSWK_07151 5.75e-16 77.4 COG4948@1|root,COG4948@2|Bacteria,2IY85@203682|Planctomycetes 203682|Planctomycetes M Mandelate racemase / muconate lactonizing enzyme, C-terminal domain - - 4.2.1.171 ko:K21624 ko00330,map00330 - R11625 - ko00000,ko00001,ko01000 - - - MR_MLE_C,MR_MLE_N k59_27198_4 1556290.A0A0A0RQH0_9CAUD 7.42e-09 63.9 4QAK6@10239|Viruses,4QPBY@28883|Caudovirales,4QKKV@10699|Siphoviridae 10699|Siphoviridae S peptidoglycan catabolic process - - - - - - - - - - - - - k59_1553044_1 643562.Daes_0884 3.4e-24 107.0 COG0642@1|root,COG2202@1|root,COG2202@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,43D8B@68525|delta/epsilon subdivisions,2X8EY@28221|Deltaproteobacteria,2M9SJ@213115|Desulfovibrionales 28221|Deltaproteobacteria T Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - - - - - - - - - - GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_9 k59_309905_1 316407.85676607 3.27e-123 362.0 COG2610@1|root,COG2610@2|Bacteria,1MUFG@1224|Proteobacteria,1RNGE@1236|Gammaproteobacteria,3XMJC@561|Escherichia 1236|Gammaproteobacteria P Low-affinity gluconate gntU GO:0003674,GO:0005215,GO:0005402,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008324,GO:0008643,GO:0015075,GO:0015144,GO:0015291,GO:0015293,GO:0015294,GO:0015318,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0022890,GO:0031224,GO:0031226,GO:0034219,GO:0034220,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0098655 - ko:K06156 - - - - ko00000,ko02000 2.A.8.1.8 - iAF1260.b4476,iB21_1397.B21_03240,iBWG_1329.BWG_3127,iEC55989_1330.EC55989_3845,iECB_1328.ECB_03287,iECDH10B_1368.ECDH10B_3609,iECDH1ME8569_1439.ECDH1ME8569_3313,iECD_1391.ECD_03287,iECH74115_1262.ECH74115_4752,iECIAI1_1343.ECIAI1_3581,iECIAI39_1322.ECIAI39_3918,iECO26_1355.ECO26_4525,iECSE_1348.ECSE_3704,iECSP_1301.ECSP_4391,iECUMN_1333.ECUMN_3899,iECs_1301.ECs4285,iEKO11_1354.EKO11_0306,iETEC_1333.ETEC_3684,iEcDH1_1363.EcDH1_0279,iEcE24377_1341.EcE24377A_3914,iEcHS_1320.EcHS_A3635,iEcSMS35_1347.EcSMS35_3719,iEcolC_1368.EcolC_0277,iG2583_1286.G2583_4138,iJO1366.b4476,iSDY_1059.SDY_3587,iUMNK88_1353.UMNK88_4205,iY75_1357.Y75_RS20045,iYL1228.KPN_03800,iZ_1308.Z4804 GntP_permease k59_1436756_1 1380390.JIAT01000010_gene4575 1.15e-19 92.4 COG1020@1|root,COG1020@2|Bacteria,2HEFF@201174|Actinobacteria,4CSGP@84995|Rubrobacteria 84995|Rubrobacteria Q Protein of unknown function (DUF1298) - - - - - - - - - - - - DUF1298,WES_acyltransf k59_1155442_2 1121017.AUFG01000012_gene1875 6.85e-14 72.4 COG1595@1|root,COG1595@2|Bacteria,2GJER@201174|Actinobacteria,4FEK4@85021|Intrasporangiaceae 201174|Actinobacteria K ECF sigma factor adsA - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 k59_531952_1 1336233.JAEH01000015_gene3247 1.39e-49 181.0 COG4773@1|root,COG4773@2|Bacteria,1QTXJ@1224|Proteobacteria,1T2NX@1236|Gammaproteobacteria,2Q91E@267890|Shewanellaceae 1236|Gammaproteobacteria P TonB-dependent receptor plug - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_1383150_1 1229909.NSED_02680 2.55e-61 201.0 COG1258@1|root,arCOG01015@2157|Archaea,41SHC@651137|Thaumarchaeota 651137|Thaumarchaeota J Responsible for synthesis of pseudouridine from uracil- 54 and uracil-55 in the psi GC loop of transfer RNAs - - 5.4.99.25 ko:K07583 - - - - ko00000,ko01000,ko03016 - - - - k59_1383150_2 1229909.NSED_02675 5.92e-194 546.0 COG0541@1|root,arCOG01228@2157|Archaea,41SDP@651137|Thaumarchaeota 651137|Thaumarchaeota U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY srp54 - 3.6.5.4 ko:K03106 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko01000,ko02044 3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9 - - SRP54,SRP54_N,SRP_SPB k59_194743_1 702113.PP1Y_AT6758 1.83e-76 256.0 COG2902@1|root,COG2902@2|Bacteria,1MXNV@1224|Proteobacteria,2TS89@28211|Alphaproteobacteria,2K0WP@204457|Sphingomonadales 204457|Sphingomonadales E glutamate dehydrogenase - - 1.4.1.2 ko:K15371 ko00220,ko00250,ko00430,ko00910,ko01100,map00220,map00250,map00430,map00910,map01100 - R00243 RC00006,RC02799 ko00000,ko00001,ko01000 - - - Bac_GDH k59_531955_1 436308.Nmar_1180 1.93e-69 213.0 COG1945@1|root,arCOG04490@2157|Archaea,41SPZ@651137|Thaumarchaeota 651137|Thaumarchaeota E Belongs to the PdaD family pdaD - 4.1.1.19 ko:K02626 ko00330,ko01100,map00330,map01100 M00133 R00566 RC00299 ko00000,ko00001,ko00002,ko01000 - - - PvlArgDC k59_531955_2 436308.Nmar_1179 4.71e-19 87.0 arCOG08686@1|root,arCOG08686@2157|Archaea,41T56@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_591422_1 713586.KB900536_gene3046 1.45e-105 315.0 COG0649@1|root,COG0649@2|Bacteria,1MVIN@1224|Proteobacteria,1RM98@1236|Gammaproteobacteria,1WWN5@135613|Chromatiales 135613|Chromatiales C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoD - 1.6.5.3 ko:K00333 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_49kDa k59_928593_1 1096930.L284_05945 2.86e-42 144.0 COG1407@1|root,COG1407@2|Bacteria,1RC5G@1224|Proteobacteria,2TU2T@28211|Alphaproteobacteria,2K25E@204457|Sphingomonadales 204457|Sphingomonadales S ICC-like phosphoesterases - - - ko:K06953 - - - - ko00000 - - - Metallophos k59_928593_2 1088721.NSU_1014 2.81e-110 318.0 COG0290@1|root,COG0290@2|Bacteria,1RDD2@1224|Proteobacteria,2U58Z@28211|Alphaproteobacteria,2K0EN@204457|Sphingomonadales 204457|Sphingomonadales J IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins infC - - ko:K02520 - - - - ko00000,ko03012,ko03029 - - - IF3_C,IF3_N k59_815429_1 627192.SLG_10280 5.18e-81 259.0 COG0438@1|root,COG0438@2|Bacteria,1RF3D@1224|Proteobacteria,2TUNA@28211|Alphaproteobacteria 28211|Alphaproteobacteria M PFAM glycosyl transferase group 1 - - - ko:K20444 - - - - ko00000,ko01000,ko01005,ko02000 4.D.1.3 GT2,GT4 - Glyco_tranf_2_3,Glyco_trans_1_4,Glycos_transf_1,RgpF k59_928594_1 977880.RALTA_A2284 3.34e-104 318.0 COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2VIA6@28216|Betaproteobacteria,1K2QB@119060|Burkholderiaceae 28216|Betaproteobacteria IQ Activates fatty acids by binding to coenzyme A fadD2 - - ko:K00666 - - - - ko00000,ko01000,ko01004 - - - AMP-binding,AMP-binding_C k59_984267_1 1229205.BUPH_03467 4.78e-123 364.0 COG0045@1|root,COG0045@2|Bacteria,1MVCE@1224|Proteobacteria,2VHBG@28216|Betaproteobacteria,1K06K@119060|Burkholderiaceae 28216|Betaproteobacteria F Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit sucC - 6.2.1.5 ko:K01903 ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374,M00620 R00405,R02404 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000 - - - ATP-grasp_2,Ligase_CoA k59_420921_1 1205908.AKXW01000045_gene3643 7.09e-55 187.0 COG1680@1|root,COG1680@2|Bacteria,1P3SQ@1224|Proteobacteria,1SWQV@1236|Gammaproteobacteria,1XSBM@135623|Vibrionales 135623|Vibrionales V Beta-lactamase - - - - - - - - - - - - Beta-lactamase k59_704732_1 1415778.JQMM01000001_gene2219 6.64e-85 278.0 COG0249@1|root,COG0249@2|Bacteria,1MUGX@1224|Proteobacteria,1RNW3@1236|Gammaproteobacteria,1J4TP@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L that it carries out the mismatch recognition step. This protein has a weak ATPase activity mutS GO:0000018,GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0008301,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019219,GO:0019222,GO:0030554,GO:0030983,GO:0031323,GO:0032136,GO:0032300,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033554,GO:0034641,GO:0035639,GO:0036094,GO:0042623,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0043531,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051171,GO:0051716,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901363,GO:1990391 - ko:K03555 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - iECW_1372.ECW_m2935,iWFL_1372.ECW_m2935 MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V k59_1553082_1 1229909.NSED_09525 8.49e-09 58.2 arCOG08685@1|root,arCOG08685@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_1553082_2 436308.Nmar_1779 7.04e-53 170.0 COG1931@1|root,arCOG01043@2157|Archaea,41SRJ@651137|Thaumarchaeota 651137|Thaumarchaeota S Belongs to the UPF0201 family - - - ko:K09736 - - - - ko00000 - - - RNA_binding k59_1436776_1 1229909.NSED_01120 6.38e-64 213.0 COG1241@1|root,arCOG00439@2157|Archaea,41SA7@651137|Thaumarchaeota 651137|Thaumarchaeota L Belongs to the MCM family - - - ko:K10726 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - MCM,MCM_N,MCM_OB k59_1436776_2 436308.Nmar_0243 1.39e-38 142.0 COG1204@1|root,arCOG00553@2157|Archaea,41SAK@651137|Thaumarchaeota 651137|Thaumarchaeota L DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks hel308 - - ko:K03726 - - - - ko00000,ko01000 - - - DEAD,HHH_5,Helicase_C k59_815438_1 935839.JAGJ01000011_gene454 1.13e-41 147.0 COG0436@1|root,COG0436@2|Bacteria,2GJ7R@201174|Actinobacteria,4F3Y8@85017|Promicromonosporaceae 201174|Actinobacteria E DegT/DnrJ/EryC1/StrS aminotransferase family - - 2.6.1.1,2.6.1.17,2.6.1.83 ko:K00812,ko:K08969,ko:K10206,ko:K14261,ko:K14267 ko00220,ko00250,ko00270,ko00300,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00300,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00034,M00527 R00355,R00694,R00734,R00896,R02433,R02619,R04475,R05052,R07396,R07613 RC00006,RC01847 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 k59_815438_2 1321778.HMPREF1982_00126 3.2e-11 64.7 COG3339@1|root,COG3339@2|Bacteria,1V7PK@1239|Firmicutes,2493Y@186801|Clostridia 186801|Clostridia S Protein of unknown function (DUF1232) - - - - - - - - - - - - DUF1232 k59_1664086_1 391615.ABSJ01000005_gene560 6.99e-68 224.0 COG0025@1|root,COG0025@2|Bacteria,1QTUE@1224|Proteobacteria,1T1HJ@1236|Gammaproteobacteria,1J5D7@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P Sodium hydrogen exchanger nhaP - - ko:K03316 - - - - ko00000 2.A.36 - - Na_H_Exchanger,TrkA_N k59_1044881_1 243365.CV_2532 2.02e-71 225.0 COG2896@1|root,COG2896@2|Bacteria,1MW3W@1224|Proteobacteria,2VHW4@28216|Betaproteobacteria,2KPS0@206351|Neisseriales 206351|Neisseriales H Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate moaA - 4.1.99.22 ko:K03639 ko00790,ko01100,ko04122,map00790,map01100,map04122 - R09394 RC03420 ko00000,ko00001,ko01000 - - - Fer4_12,Mob_synth_C,Radical_SAM k59_1098491_1 1128421.JAGA01000003_gene3340 6.11e-06 56.2 COG3629@1|root,COG3899@1|root,COG3629@2|Bacteria,COG3899@2|Bacteria 2|Bacteria T PFAM Protein kinase domain - - - - - - - - - - - - AAA_16,BTAD,GerE,TPR_12,Trans_reg_C k59_309953_2 397278.JOJN01000001_gene2682 1.52e-61 196.0 COG0233@1|root,COG0233@2|Bacteria,2GJ9J@201174|Actinobacteria,4DNKY@85009|Propionibacteriales 201174|Actinobacteria J Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another frr GO:0002181,GO:0002184,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008079,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016043,GO:0019538,GO:0022411,GO:0030312,GO:0032984,GO:0034641,GO:0034645,GO:0040007,GO:0043021,GO:0043023,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044464,GO:0044877,GO:0071704,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - ko:K02838 - - - - ko00000,ko03012 - - - RRF k59_309953_3 526225.Gobs_3989 5.85e-14 70.9 COG0528@1|root,COG0528@2|Bacteria,2GKWQ@201174|Actinobacteria,4ERFG@85013|Frankiales 201174|Actinobacteria F Catalyzes the reversible phosphorylation of UMP to UDP pyrH GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006213,GO:0006220,GO:0006221,GO:0006225,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009163,GO:0009165,GO:0009185,GO:0009188,GO:0009193,GO:0009194,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019693,GO:0033862,GO:0034404,GO:0034641,GO:0034654,GO:0040007,GO:0042455,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046048,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0046872,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.7.4.22 ko:K09903 ko00240,ko01100,map00240,map01100 - R00158 RC00002 ko00000,ko00001,ko01000 - - - AA_kinase k59_928610_1 1415778.JQMM01000001_gene1749 5.56e-141 420.0 COG0542@1|root,COG0542@2|Bacteria,1MV8B@1224|Proteobacteria,1RMH3@1236|Gammaproteobacteria,1J5A1@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O Belongs to the ClpA ClpB family clpA GO:0000166,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0043335,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0070011,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564 - ko:K03694 - - - - ko00000,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N k59_704745_1 675635.Psed_4852 3.25e-06 48.9 2EG8Z@1|root,33A0S@2|Bacteria,2I8BH@201174|Actinobacteria,4E6WY@85010|Pseudonocardiales 201174|Actinobacteria - - - - - - - - - - - - - - - k59_704745_2 160492.XF_1762 5.52e-57 182.0 2C5J1@1|root,3067M@2|Bacteria,1N4SF@1224|Proteobacteria,1TCN1@1236|Gammaproteobacteria,1XA5Q@135614|Xanthomonadales 135614|Xanthomonadales - - - - - - - - - - - - - - - k59_1775220_1 203122.Sde_1633 1.22e-79 247.0 COG1559@1|root,COG1559@2|Bacteria,1MUQF@1224|Proteobacteria,1RMWD@1236|Gammaproteobacteria,4650E@72275|Alteromonadaceae 1236|Gammaproteobacteria S Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation mltG GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006022,GO:0006807,GO:0008150,GO:0008152,GO:0008932,GO:0008933,GO:0016020,GO:0016021,GO:0016740,GO:0016757,GO:0030203,GO:0030288,GO:0030313,GO:0031224,GO:0031226,GO:0031975,GO:0042597,GO:0043170,GO:0044425,GO:0044459,GO:0044464,GO:0061783,GO:0071704,GO:0071944,GO:1901135,GO:1901564 - ko:K07082 - - - - ko00000 - - - YceG k59_1775220_2 207954.MED92_09723 4.29e-15 72.4 COG0125@1|root,COG0125@2|Bacteria,1MV9C@1224|Proteobacteria,1S26C@1236|Gammaproteobacteria,1XJCZ@135619|Oceanospirillales 135619|Oceanospirillales F Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis tmk - 2.7.4.9 ko:K00943 ko00240,ko01100,map00240,map01100 M00053 R02094,R02098 RC00002 ko00000,ko00001,ko00002,ko01000 - - - Thymidylate_kin k59_984296_1 765910.MARPU_10285 4.52e-15 73.6 COG0790@1|root,COG0790@2|Bacteria,1PFSC@1224|Proteobacteria,1TJ65@1236|Gammaproteobacteria,1WY15@135613|Chromatiales 135613|Chromatiales S Sel1-like repeats. - - - ko:K07126 - - - - ko00000 - - - Sel1 k59_1213130_1 91464.S7335_3783 1.68e-44 150.0 COG0563@1|root,COG0563@2|Bacteria,1G696@1117|Cyanobacteria 1117|Cyanobacteria F COG0563 Adenylate kinase and related - - - - - - - - - - - - AAA_18,PduV-EutP,SKI k59_1044909_1 756272.Plabr_1392 6.87e-16 76.6 COG0449@1|root,COG0449@2|Bacteria,2IXF9@203682|Planctomycetes 203682|Planctomycetes M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source glmS - 2.6.1.16 ko:K00820 ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931 - R00768 RC00010,RC00163,RC02752 ko00000,ko00001,ko01000,ko01002 - - - GATase_6,SIS k59_194796_1 1122137.AQXF01000001_gene3023 1.23e-81 264.0 COG0532@1|root,COG0532@2|Bacteria,1MV26@1224|Proteobacteria,2TQMY@28211|Alphaproteobacteria 28211|Alphaproteobacteria J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex infB - - ko:K02519 - - - - ko00000,ko03012,ko03029 - - - GTP_EFTU,GTP_EFTU_D2,IF-2,IF2_N,IF2_assoc k59_194796_2 1502724.FF80_04156 6.69e-27 102.0 COG0858@1|root,COG0858@2|Bacteria,1MZPE@1224|Proteobacteria,2UCJF@28211|Alphaproteobacteria,3N72E@45401|Hyphomicrobiaceae 28211|Alphaproteobacteria J One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA rbfA - - ko:K02834 - - - - ko00000,ko03009 - - - RBFA k59_1553133_1 1123392.AQWL01000002_gene1978 2.11e-63 218.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2VHFI@28216|Betaproteobacteria,1KSKV@119069|Hydrogenophilales 119069|Hydrogenophilales V MMPL family - - - - - - - - - - - - ACR_tran k59_1267577_1 1122137.AQXF01000001_gene3388 1.01e-92 278.0 COG0824@1|root,COG0824@2|Bacteria,1R6A6@1224|Proteobacteria,2TU6J@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Thioesterase - - - - - - - - - - - - - k59_1267580_1 909663.KI867150_gene2871 2.7e-24 106.0 COG3039@1|root,COG3039@2|Bacteria,1QY2X@1224|Proteobacteria 1224|Proteobacteria L Transposase DDE domain - - - - - - - - - - - - DDE_Tnp_1_6 k59_84412_1 983545.Glaag_3684 9.36e-07 57.0 COG3107@1|root,COG3107@2|Bacteria,1MUHR@1224|Proteobacteria,1RXX4@1236|Gammaproteobacteria,465I7@72275|Alteromonadaceae 1236|Gammaproteobacteria M (Lipo)protein lpoA GO:0000270,GO:0003674,GO:0005575,GO:0005623,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009279,GO:0009987,GO:0016020,GO:0019867,GO:0030203,GO:0030234,GO:0030312,GO:0030313,GO:0031241,GO:0031975,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044425,GO:0044462,GO:0044464,GO:0050790,GO:0065007,GO:0065009,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:0098552,GO:0098772,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 - ko:K07121 - - - - ko00000 - - - LppC k59_1098527_1 1123487.KB892864_gene2090 1.51e-32 131.0 COG1143@1|root,COG5373@1|root,COG1143@2|Bacteria,COG5373@2|Bacteria,1N08V@1224|Proteobacteria,2VKJT@28216|Betaproteobacteria,2KVH0@206389|Rhodocyclales 206389|Rhodocyclales C Predicted membrane protein (DUF2339) - - - - - - - - - - - - DUF2339 k59_704796_1 627192.SLG_06480 9.51e-14 70.5 COG4122@1|root,COG4122@2|Bacteria,1N57D@1224|Proteobacteria,2U6NA@28211|Alphaproteobacteria,2KCBH@204457|Sphingomonadales 204457|Sphingomonadales S O-methyltransferase - - - - - - - - - - - - Methyltransf_24 k59_704796_2 279238.Saro_3426 1.25e-73 223.0 COG0346@1|root,COG0346@2|Bacteria,1NGED@1224|Proteobacteria,2URUV@28211|Alphaproteobacteria,2K8D3@204457|Sphingomonadales 204457|Sphingomonadales E Glyoxalase-like domain - - - - - - - - - - - - Glyoxalase_4 k59_704796_3 1207055.C100_16795 2.84e-50 169.0 COG1506@1|root,COG1506@2|Bacteria,1QURS@1224|Proteobacteria,2TW50@28211|Alphaproteobacteria,2KEAZ@204457|Sphingomonadales 204457|Sphingomonadales E BAAT / Acyl-CoA thioester hydrolase C terminal - - - - - - - - - - - - BAAT_C,Peptidase_S9 k59_1267610_1 1248917.ANFX01000008_gene318 0.000257 48.5 COG1792@1|root,COG1792@2|Bacteria,1N8ZS@1224|Proteobacteria,2U1FY@28211|Alphaproteobacteria,2K18A@204457|Sphingomonadales 204457|Sphingomonadales M Involved in formation and maintenance of cell shape mreC - - ko:K03570 - - - - ko00000,ko03036 9.B.157.1 - - MreC k59_252248_1 436308.Nmar_0002 7.8e-221 618.0 COG1311@1|root,arCOG04455@2157|Archaea,41T0D@651137|Thaumarchaeota 651137|Thaumarchaeota L Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase polB - 2.7.7.7 ko:K02323 ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030 M00264 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032 - - - DNA_pol_E_B k59_476560_1 187272.Mlg_1537 1.53e-13 65.5 COG4877@1|root,COG4877@2|Bacteria,1NNE2@1224|Proteobacteria,1SGNK@1236|Gammaproteobacteria,1WZNZ@135613|Chromatiales 135613|Chromatiales S Ribbon-helix-helix protein, copG family - - - - - - - - - - - - RHH_1,RHH_5 k59_476560_3 1042377.AFPJ01000037_gene3016 1.08e-10 59.3 2E80T@1|root,332F0@2|Bacteria,1N7RY@1224|Proteobacteria,1SCE8@1236|Gammaproteobacteria,467UH@72275|Alteromonadaceae 1236|Gammaproteobacteria S Domain of unknown function (DUF4389) - - - - - - - - - - - - DUF4389 k59_1098551_1 1219035.NT2_07_00620 1.96e-23 105.0 COG4774@1|root,COG4774@2|Bacteria,1QPVC@1224|Proteobacteria,2U4WC@28211|Alphaproteobacteria,2K32N@204457|Sphingomonadales 204457|Sphingomonadales P TonB-dependent Receptor Plug Domain - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_310034_1 702113.PP1Y_AT3818 2.03e-75 231.0 COG3474@1|root,COG3474@2|Bacteria,1RIDN@1224|Proteobacteria,2U142@28211|Alphaproteobacteria,2K42S@204457|Sphingomonadales 204457|Sphingomonadales C cytochrome C - - - ko:K08738 ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416 M00595 R10151 RC03151,RC03152 ko00000,ko00001,ko00002 3.D.4.6 - - Cytochrom_C k59_1098554_1 1392489.JPOL01000002_gene1855 1.14e-27 110.0 COG1395@1|root,COG1395@2|Bacteria,4PNNA@976|Bacteroidetes,1IKK9@117743|Flavobacteriia 976|Bacteroidetes K SusD family - - - - - - - - - - - - SusD-like_3,SusD_RagB k59_1098554_2 1202532.FF52_14634 2.23e-39 140.0 COG3291@1|root,COG3291@2|Bacteria,4NRIG@976|Bacteroidetes,1I3TW@117743|Flavobacteriia,2NTVQ@237|Flavobacterium 976|Bacteroidetes S Pkd domain containing protein - - - - - - - - - - - - PKD k59_1775263_1 580340.Tlie_0959 1.68e-17 91.7 COG2265@1|root,COG2265@2|Bacteria,3TAIZ@508458|Synergistetes 508458|Synergistetes H Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family rumA - 2.1.1.190 ko:K03215 - - - - ko00000,ko01000,ko03009 - - - TRAM,tRNA_U5-meth_tr k59_1213182_1 1131266.ARWQ01000010_gene28 3.99e-45 154.0 COG1355@1|root,arCOG01728@2157|Archaea,41S9D@651137|Thaumarchaeota 651137|Thaumarchaeota S Belongs to the MEMO1 family - - - ko:K06990 - - - - ko00000,ko04812 - - - Memo k59_1213182_2 1229909.NSED_01525 2.28e-128 367.0 COG0052@1|root,arCOG04245@2157|Archaea,41SG7@651137|Thaumarchaeota 651137|Thaumarchaeota J Belongs to the universal ribosomal protein uS2 family rps2 - - ko:K02967 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S2 k59_1776081_1 1088721.NSU_1167 2.22e-50 162.0 2CJTV@1|root,33GYN@2|Bacteria,1P2TE@1224|Proteobacteria,2UVIM@28211|Alphaproteobacteria,2K83W@204457|Sphingomonadales 204457|Sphingomonadales - - - - - - - - - - - - - - - k59_28780_1 1229909.NSED_08780 1.37e-146 419.0 COG0604@1|root,arCOG01458@2157|Archaea,41SZ9@651137|Thaumarchaeota 651137|Thaumarchaeota C PFAM Alcohol dehydrogenase GroES-like domain - - - - - - - - - - - - ADH_N,ADH_zinc_N k59_28783_1 1380356.JNIK01000017_gene2822 2.87e-09 64.3 COG1529@1|root,COG1529@2|Bacteria,2GIVI@201174|Actinobacteria,4ETP4@85013|Frankiales 201174|Actinobacteria C aldehyde oxidase and xanthine dehydrogenase, a b hammerhead - - 1.2.5.3,1.5.99.4 ko:K03520,ko:K19820 ko00760,ko01120,map00760,map01120 M00810 R02860,R07946,R11168 RC00589,RC02800 ko00000,ko00001,ko00002,ko01000 - - - Ald_Xan_dh_C,Ald_Xan_dh_C2 k59_28786_1 871585.BDGL_003043 6.05e-07 55.8 COG1033@1|root,COG1033@2|Bacteria,1MUE1@1224|Proteobacteria,1RPIP@1236|Gammaproteobacteria,3NM9J@468|Moraxellaceae 1236|Gammaproteobacteria GM Outer membrane lipoprotein-sorting protein - - - ko:K07003 - - - - ko00000 - - - LolA_like,MMPL,Polyketide_cyc2 k59_1268565_1 402881.Plav_2837 4.03e-160 468.0 COG1960@1|root,COG1960@2|Bacteria,1MU20@1224|Proteobacteria,2TQU2@28211|Alphaproteobacteria,1JN9N@119043|Rhodobiaceae 28211|Alphaproteobacteria I Acyl-CoA dehydrogenase, C-terminal domain aidB GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003995,GO:0005488,GO:0005515,GO:0006355,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008470,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016491,GO:0016627,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0033554,GO:0042802,GO:0043565,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051716,GO:0055114,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 - ko:K09456 - - - - ko00000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M k59_1384634_1 1121106.JQKB01000004_gene2309 4.19e-69 225.0 COG0477@1|root,COG0477@2|Bacteria,1QTTP@1224|Proteobacteria,2TVY9@28211|Alphaproteobacteria,2JR3G@204441|Rhodospirillales 204441|Rhodospirillales EGP Major facilitator superfamily - - - - - - - - - - - - MFS_1 k59_368295_1 158500.BV97_00951 2.9e-89 280.0 COG2936@1|root,COG2936@2|Bacteria,1MVA8@1224|Proteobacteria,2U29S@28211|Alphaproteobacteria,2K0TJ@204457|Sphingomonadales 204457|Sphingomonadales S X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain - - - ko:K06978 - - - - ko00000 - - - PepX_C,Peptidase_S15 k59_368299_1 1187848.AJYQ01000003_gene410 8.4e-185 526.0 COG3653@1|root,COG3653@2|Bacteria,1MWWY@1224|Proteobacteria,1TFGA@1236|Gammaproteobacteria,1XXNF@135623|Vibrionales 135623|Vibrionales Q Amidohydrolase family - - - - - - - - - - - - Amidohydro_3 k59_706181_1 316407.85675645 6.47e-118 358.0 COG3605@1|root,COG3605@2|Bacteria,1QTTV@1224|Proteobacteria,1T1H2@1236|Gammaproteobacteria,3XPFC@561|Escherichia 1236|Gammaproteobacteria T Component of the phosphoenolpyruvate-dependent nitrogen- metabolic phosphotransferase system (nitrogen-metabolic PTS), that seems to be involved in regulating nitrogen metabolism. Enzyme I- Ntr transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (NPr). Could function in the transcriptional regulation of sigma-54 dependent operons in conjunction with the NPr (PtsO) and EIIA-Ntr (PtsN) proteins. Enzyme I-Ntr is specific for NPr ptsP GO:0003674,GO:0003824,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008965,GO:0009987,GO:0010033,GO:0010243,GO:0016310,GO:0016740,GO:0016772,GO:0016775,GO:0019538,GO:0036211,GO:0042221,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0050896,GO:0071704,GO:1901564,GO:1901698 2.7.3.9 ko:K08483,ko:K08484 ko02060,map02060 - - - ko00000,ko00001,ko01000,ko02000 8.A.7 - - GAF,GAF_2,PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C k59_1783030_3 236097.ADG881_3085 4.86e-15 73.6 COG2928@1|root,COG2928@2|Bacteria,1NF4R@1224|Proteobacteria,1SFUD@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Conserved Protein - - - - - - - - - - - - DUF502 k59_148858_1 465541.ATCJ01000005_gene2055 8.36e-51 179.0 COG3321@1|root,COG3321@2|Bacteria,2IGI7@201174|Actinobacteria 201174|Actinobacteria Q polyketide synthase - - - - - - - - - - - - ACPS,Acyl_transf_1,KAsynt_C_assoc,Ketoacyl-synt_C,PS-DH,ketoacyl-synt k59_322172_1 1129794.C427_5517 4.12e-56 196.0 COG2272@1|root,COG2272@2|Bacteria,1MVQZ@1224|Proteobacteria,1RPFW@1236|Gammaproteobacteria,465DX@72275|Alteromonadaceae 1236|Gammaproteobacteria I Carboxylesterase family - - - ko:K03929 - - - - ko00000,ko01000 - CE10 - COesterase k59_826658_1 641526.ADIWIN_1353 2.38e-43 147.0 2BAFY@1|root,323WE@2|Bacteria,4NQ3E@976|Bacteroidetes,1I30F@117743|Flavobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_826658_2 1137281.D778_01355 4.67e-94 288.0 COG3595@1|root,COG3595@2|Bacteria,4NEUW@976|Bacteroidetes,1HYD6@117743|Flavobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_38964_1 1121116.KB894769_gene1329 1.8e-28 108.0 COG1576@1|root,COG1576@2|Bacteria,1R9Z2@1224|Proteobacteria,2VQ2M@28216|Betaproteobacteria,4A9YK@80864|Comamonadaceae 28216|Betaproteobacteria J Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA rlmH - 2.1.1.177 ko:K00783 - - - - ko00000,ko01000,ko03009 - - - SPOUT_MTase k59_38964_2 762376.AXYL_02104 3.82e-40 142.0 COG0424@1|root,COG0424@2|Bacteria,1RH6H@1224|Proteobacteria,2VQC3@28216|Betaproteobacteria,3T3UB@506|Alcaligenaceae 28216|Betaproteobacteria D Maf-like protein maf - - ko:K06287 - - - - ko00000 - - - Maf k59_1783035_1 1178825.ALIH01000017_gene663 7.98e-135 399.0 COG4773@1|root,COG4773@2|Bacteria,4PKTX@976|Bacteroidetes,1HXIR@117743|Flavobacteriia 976|Bacteroidetes P Receptor - - - - - - - - - - - - TonB_dep_Rec k59_826665_1 1415779.JOMH01000001_gene657 4.39e-11 63.5 COG0026@1|root,COG0026@2|Bacteria,1MU70@1224|Proteobacteria,1RQEI@1236|Gammaproteobacteria,1X31G@135614|Xanthomonadales 135614|Xanthomonadales F Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) purK - 6.3.4.18 ko:K01589 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R07404 RC01927 ko00000,ko00001,ko00002,ko01000 - - - ATP-grasp k59_826665_2 526227.Mesil_1294 6.52e-76 231.0 COG0041@1|root,COG0041@2|Bacteria,1WJ89@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus F Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) purE - 5.4.99.18 ko:K01588 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R07405 RC01947 ko00000,ko00001,ko00002,ko01000 - - - AIRC k59_1565606_1 1122137.AQXF01000001_gene3012 9.04e-69 212.0 COG3807@1|root,COG3807@2|Bacteria,1RHM2@1224|Proteobacteria,2UA1R@28211|Alphaproteobacteria 28211|Alphaproteobacteria S protein conserved in bacteria MA20_24010 - 6.1.1.12 ko:K01876 ko00970,map00970 M00359,M00360 R05577 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - SH3_4 k59_886923_1 446471.Xcel_2972 1.43e-31 117.0 COG0588@1|root,COG0588@2|Bacteria,2GK8F@201174|Actinobacteria,4F3C0@85017|Promicromonosporaceae 201174|Actinobacteria G Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate gpmA GO:0003674,GO:0003824,GO:0004619,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0005996,GO:0006006,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006109,GO:0006139,GO:0006140,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009894,GO:0009987,GO:0010675,GO:0016020,GO:0016043,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016866,GO:0016868,GO:0017144,GO:0018130,GO:0019219,GO:0019220,GO:0019222,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0022607,GO:0031323,GO:0031329,GO:0032787,GO:0032991,GO:0034248,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042802,GO:0042866,GO:0043436,GO:0043455,GO:0043456,GO:0043470,GO:0043471,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046538,GO:0046700,GO:0046939,GO:0050789,GO:0050794,GO:0051171,GO:0051174,GO:0051186,GO:0051188,GO:0051193,GO:0051196,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055086,GO:0060255,GO:0062012,GO:0065003,GO:0065007,GO:0071704,GO:0071840,GO:0071944,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0080090,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1902031 5.4.2.11 ko:K01834 ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko05230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map05230 M00001,M00002,M00003 R01518 RC00536 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - His_Phos_1 k59_1672919_2 228405.HNE_1959 1.43e-07 52.8 COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2TR7Q@28211|Alphaproteobacteria,43WK1@69657|Hyphomonadaceae 28211|Alphaproteobacteria C acyl-CoA transferases carnitine dehydratase - - 2.8.3.16 ko:K07749 - - - - ko00000,ko01000 - - - CoA_transf_3 k59_1166927_1 136273.GY22_15995 1.88e-30 119.0 COG2227@1|root,COG2227@2|Bacteria,2IIE2@201174|Actinobacteria 201174|Actinobacteria H 3-demethylubiquinone-9 3-O-methyltransferase activity - - 2.1.1.11 ko:K03428 ko00860,ko01100,ko01110,map00860,map01100,map01110 - R04237 RC00003,RC00460 ko00000,ko00001,ko01000 - - - Methyltransf_11,Methyltransf_25 k59_716763_1 1348657.M622_03650 3.7e-97 300.0 COG0342@1|root,COG0342@2|Bacteria,1MV5U@1224|Proteobacteria,2VHKD@28216|Betaproteobacteria,2KV11@206389|Rhodocyclales 206389|Rhodocyclales U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA secD - - ko:K03072 ko03060,ko03070,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 2.A.6.4,3.A.5.2,3.A.5.7 - - SecD-TM1,SecD_SecF,Sec_GG k59_1333041_1 1408419.JHYG01000002_gene857 4.54e-71 231.0 COG3243@1|root,COG3243@2|Bacteria,1MU68@1224|Proteobacteria,2TR7S@28211|Alphaproteobacteria,2JQ99@204441|Rhodospirillales 204441|Rhodospirillales I poly-beta-hydroxybutyrate polymerase - - - ko:K03821 ko00650,map00650 - R04254 RC00004 ko00000,ko00001,ko01000 - - - PHBC_N,PhaC_N k59_1731035_2 436308.Nmar_1732 1.26e-39 135.0 COG1056@1|root,arCOG00972@2157|Archaea,41T7B@651137|Thaumarchaeota 651137|Thaumarchaeota H Cytidylyltransferase-like - - 2.7.7.1 ko:K00952 ko00760,ko01100,map00760,map01100 - R00137,R03005 RC00002 ko00000,ko00001,ko01000 - - - CTP_transf_like k59_1672925_1 1296415.JACC01000009_gene1971 2.42e-34 119.0 COG0346@1|root,COG0346@2|Bacteria,4NNNG@976|Bacteroidetes,1I1XF@117743|Flavobacteriia,2YJF6@290174|Aquimarina 976|Bacteroidetes E glyoxalase - - - - - - - - - - - - Glyoxalase k59_1672925_2 1094466.KQS_07115 1.37e-79 239.0 COG5646@1|root,COG5646@2|Bacteria,4NNPA@976|Bacteroidetes,1I1Y8@117743|Flavobacteriia,2NWCA@237|Flavobacterium 976|Bacteroidetes S Domain of unknown function (DU1801) - - - - - - - - - - - - DUF1801 k59_1107624_1 94122.Shewana3_0326 7e-121 356.0 COG0304@1|root,COG0304@2|Bacteria,1MU1X@1224|Proteobacteria,1RQH7@1236|Gammaproteobacteria,2Q9QY@267890|Shewanellaceae 1236|Gammaproteobacteria IQ Belongs to the beta-ketoacyl-ACP synthases family fabF1 - 2.3.1.179 ko:K09458 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119 RC00039,RC02728,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Ketoacyl-synt_C,ketoacyl-synt k59_1731042_1 1522072.IL54_2804 5.05e-46 160.0 COG0438@1|root,COG0438@2|Bacteria,1R2D7@1224|Proteobacteria,2TZI1@28211|Alphaproteobacteria,2KEUC@204457|Sphingomonadales 204457|Sphingomonadales M Sulfotransferase family - - - - - - - - - - - - Sulfotransfer_3 k59_1731042_2 1194972.MVAC_16776 1.22e-32 117.0 2EUA2@1|root,32E0M@2|Bacteria,2HBJI@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - - k59_716773_1 247633.GP2143_03044 1.36e-16 78.2 COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,1RMBQ@1236|Gammaproteobacteria,1J4DZ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Belongs to the aldehyde dehydrogenase family gabD - 1.2.1.16,1.2.1.20,1.2.1.79 ko:K00135 ko00250,ko00310,ko00350,ko00650,ko00760,ko01100,ko01120,map00250,map00310,map00350,map00650,map00760,map01100,map01120 M00027 R00713,R00714,R02401 RC00080 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_886934_1 452652.KSE_61090 1.47e-16 78.2 COG4122@1|root,COG4122@2|Bacteria,2I80B@201174|Actinobacteria,2M4W5@2063|Kitasatospora 201174|Actinobacteria S Methyltransferase domain - - - - - - - - - - - - Methyltransf_24 k59_886934_2 1122137.AQXF01000003_gene1888 8.78e-88 261.0 COG0231@1|root,COG0231@2|Bacteria,1MW2J@1224|Proteobacteria,2TUWE@28211|Alphaproteobacteria 28211|Alphaproteobacteria J Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase efp - - ko:K02356 - - - - ko00000,ko03012 - - - EFP,EFP_N,Elong-fact-P_C k59_540378_2 1209984.BN978_03837 4.14e-41 145.0 COG0320@1|root,COG0320@2|Bacteria,2GKD4@201174|Actinobacteria,2368Y@1762|Mycobacteriaceae 201174|Actinobacteria H Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives lipA - 2.8.1.8 ko:K03644 ko00785,ko01100,map00785,map01100 - R07767,R07768 RC01978 ko00000,ko00001,ko01000 - - - LIAS_N,Radical_SAM k59_1618589_1 247633.GP2143_01540 6.88e-140 405.0 COG0582@1|root,COG0582@2|Bacteria,1MWBN@1224|Proteobacteria,1RPD0@1236|Gammaproteobacteria,1JC11@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L Phage integrase family intD GO:0000150,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006310,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008907,GO:0008979,GO:0009009,GO:0009987,GO:0015074,GO:0016032,GO:0019042,GO:0019043,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044403,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051704,GO:0071704,GO:0075713,GO:0090304,GO:0140097,GO:1901360 - ko:K03111 ko03030,ko03430,ko03440,map03030,map03430,map03440 - - - ko00000,ko00001,ko03029,ko03032,ko03400 - - - Phage_integrase k59_1395283_1 1396141.BATP01000047_gene3950 2.17e-30 111.0 COG0776@1|root,COG0776@2|Bacteria,46XH3@74201|Verrucomicrobia,2IVWK@203494|Verrucomicrobiae 203494|Verrucomicrobiae L Bacterial DNA-binding protein - - - - - - - - - - - - Bac_DNA_binding k59_1395283_2 1163407.UU7_07791 3.44e-34 126.0 COG2945@1|root,COG2945@2|Bacteria,1MUDY@1224|Proteobacteria,1S4MG@1236|Gammaproteobacteria,1X4H4@135614|Xanthomonadales 135614|Xanthomonadales S Alpha beta - - - ko:K07018 - - - - ko00000 - - - Hydrolase_4,Peptidase_S15 k59_1107654_1 671143.DAMO_1101 2.11e-90 285.0 COG0581@1|root,COG0581@2|Bacteria,2NPJS@2323|unclassified Bacteria 2|Bacteria P phosphate transport system permease protein pstA - - ko:K02038 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - BPD_transp_1 k59_767677_2 472759.Nhal_1431 2.75e-133 394.0 COG1012@1|root,COG1012@2|Bacteria,1MW72@1224|Proteobacteria,1RY9G@1236|Gammaproteobacteria,1X2DF@135613|Chromatiales 135613|Chromatiales C Aldehyde dehydrogenase family - - 1.2.1.3 ko:K00128 ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130 M00135 R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146 RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_603747_1 262316.MAP_4129 3.35e-28 114.0 COG1135@1|root,COG1135@2|Bacteria,2I46P@201174|Actinobacteria,23293@1762|Mycobacteriaceae 201174|Actinobacteria P ABC transporter mkl GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006810,GO:0006869,GO:0008150,GO:0010876,GO:0015850,GO:0015918,GO:0016020,GO:0030301,GO:0030312,GO:0033036,GO:0035376,GO:0044464,GO:0051179,GO:0051234,GO:0070508,GO:0071702,GO:0071944 - ko:K02065 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - ABC_tran k59_1223119_1 1122137.AQXF01000004_gene1824 1.26e-20 89.4 COG4974@1|root,COG4974@2|Bacteria,1MVNF@1224|Proteobacteria,2TRAA@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Belongs to the 'phage' integrase family xerD - - ko:K04763 - - - - ko00000,ko03036 - - - Phage_int_SAM_1,Phage_integrase k59_1166985_1 1056820.KB900645_gene3437 4.06e-74 235.0 COG3705@1|root,COG3705@2|Bacteria,1MWIG@1224|Proteobacteria,1RPRQ@1236|Gammaproteobacteria,2PN4N@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria E Histidyl-tRNA synthetase hisZ - - ko:K02502 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R01071 RC02819,RC03200 ko00000,ko00001,ko00002 - - - tRNA-synt_His k59_826726_1 1049564.TevJSym_ad00730 2.24e-41 141.0 COG1267@1|root,COG1267@2|Bacteria,1MZJA@1224|Proteobacteria,1S68A@1236|Gammaproteobacteria,1J67X@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria I Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG) pgpA GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006629,GO:0006644,GO:0006650,GO:0006655,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0008962,GO:0009058,GO:0009987,GO:0010035,GO:0010038,GO:0016020,GO:0016021,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019637,GO:0030258,GO:0031224,GO:0031226,GO:0032026,GO:0042221,GO:0042577,GO:0042578,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044425,GO:0044459,GO:0044464,GO:0045017,GO:0046471,GO:0046474,GO:0046486,GO:0046839,GO:0050896,GO:0071704,GO:0071944,GO:0090407,GO:1901576 3.1.3.27 ko:K01095 ko00564,ko01100,map00564,map01100 - R02029 RC00017 ko00000,ko00001,ko01000 - - iECSP_1301.ECSP_0485,iECUMN_1333.ECUMN_0456,iECs_1301.ECs0471,iG2583_1286.G2583_0529,iPC815.YPO3179,iZ_1308.Z0520 PgpA k59_1107663_2 342610.Patl_3495 1.26e-08 60.1 2AEW5@1|root,314TS@2|Bacteria,1NQA7@1224|Proteobacteria 1224|Proteobacteria S Aerotolerance regulator N-terminal - - - - - - - - - - - - BatA k59_322234_1 1211115.ALIQ01000078_gene4125 3.33e-34 135.0 28JZQ@1|root,2Z9PN@2|Bacteria,1N2WN@1224|Proteobacteria,2U0QD@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_263683_1 396588.Tgr7_2391 2.32e-25 107.0 COG3206@1|root,COG3206@2|Bacteria,1MVBX@1224|Proteobacteria,1RXY8@1236|Gammaproteobacteria,1WWGP@135613|Chromatiales 135613|Chromatiales M Polysaccharide chain length determinant protein - - - - - - - - - - - - GNVR,Wzz k59_1731084_1 1280944.HY17_06020 6.3e-35 139.0 COG1629@1|root,COG4771@2|Bacteria,1MWKN@1224|Proteobacteria,2U131@28211|Alphaproteobacteria 28211|Alphaproteobacteria P TonB dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_886964_2 629773.AORY01000002_gene1553 1.45e-43 154.0 COG1228@1|root,COG1228@2|Bacteria,1MVAF@1224|Proteobacteria,2TTYC@28211|Alphaproteobacteria,2K0Q2@204457|Sphingomonadales 204457|Sphingomonadales Q COG1228 Imidazolonepropionase and related amidohydrolases - - - - - - - - - - - - Amidohydro_1 k59_94632_1 1411685.U062_00180 2.07e-29 115.0 COG0626@1|root,COG0626@2|Bacteria,1MU57@1224|Proteobacteria,1RMCV@1236|Gammaproteobacteria 1236|Gammaproteobacteria E Catalyzes the formation of L-homocysteine from O- succinyl-L-homoserine (OSHS) and hydrogen sulfide metZ - - ko:K10764 ko00270,ko00920,ko01100,map00270,map00920,map01100 - R01288 RC00020,RC02848 ko00000,ko00001,ko01000 - - - Cys_Met_Meta_PP k59_94632_2 258594.RPA4333 5e-18 84.7 COG2133@1|root,COG2133@2|Bacteria,1MV2E@1224|Proteobacteria,2TR47@28211|Alphaproteobacteria,3JTX8@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria G Glucose / Sorbosone dehydrogenase yliI GO:0003674,GO:0003824,GO:0005488,GO:0005509,GO:0005575,GO:0005623,GO:0008150,GO:0008152,GO:0016491,GO:0016614,GO:0016901,GO:0019842,GO:0030288,GO:0030313,GO:0031406,GO:0031975,GO:0036094,GO:0042597,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0044464,GO:0046872,GO:0048037,GO:0048038,GO:0055114,GO:0070968,GO:0097159,GO:1901363 1.1.5.2 ko:K00117,ko:K21430 ko00030,ko01100,ko01110,ko01130,map00030,map01100,map01110,map01130 - R06620 RC00066 ko00000,ko00001,ko01000 - - - GSDH k59_826740_1 1173022.Cri9333_3479 2.23e-07 53.1 COG0839@1|root,COG0839@2|Bacteria,1G2WH@1117|Cyanobacteria,1H7HW@1150|Oscillatoriales 1117|Cyanobacteria C NADH ubiquinone oxidoreductase subunit 6 (chain J) ndhG - 1.6.5.3 ko:K05578 ko00190,ko01100,map00190,map01100 M00145 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 - - - Oxidored_q3 k59_826740_2 543632.JOJL01000008_gene5677 2.68e-07 54.3 COG1143@1|root,COG1143@2|Bacteria,2GPSS@201174|Actinobacteria,4DB0N@85008|Micromonosporales 201174|Actinobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoI2 - 1.6.5.3 ko:K00338 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Fer4 k59_39036_1 1046724.KB889829_gene3011 6.57e-31 118.0 COG1131@1|root,COG1131@2|Bacteria,1MUW7@1224|Proteobacteria,1RMC5@1236|Gammaproteobacteria,4653C@72275|Alteromonadaceae 1236|Gammaproteobacteria V COG1131 ABC-type multidrug transport system, ATPase component - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_39036_2 1163409.UUA_15086 6.03e-96 285.0 COG0842@1|root,COG0842@2|Bacteria,1MUH1@1224|Proteobacteria,1RP0Z@1236|Gammaproteobacteria,1X3BP@135614|Xanthomonadales 135614|Xanthomonadales V Transport permease protein yadH - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane k59_540430_1 1121940.AUDZ01000013_gene600 2.25e-63 213.0 COG0449@1|root,COG0449@2|Bacteria,1MW4K@1224|Proteobacteria,1RMVN@1236|Gammaproteobacteria,1XHD3@135619|Oceanospirillales 135619|Oceanospirillales M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source glmS - 2.6.1.16 ko:K00820 ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931 - R00768 RC00010,RC00163,RC02752 ko00000,ko00001,ko01000,ko01002 - - - GATase_6,SIS k59_938008_1 1415778.JQMM01000001_gene746 1.69e-90 279.0 COG0615@1|root,COG2870@1|root,COG0615@2|Bacteria,COG2870@2|Bacteria,1MV3Z@1224|Proteobacteria,1RMAJ@1236|Gammaproteobacteria,1J4II@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose hldE GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0006629,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008219,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009311,GO:0009312,GO:0009987,GO:0012501,GO:0016051,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016779,GO:0019200,GO:0033692,GO:0033785,GO:0033786,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0046401,GO:0046835,GO:0070566,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 2.7.1.167,2.7.7.70 ko:K03272,ko:K21344 ko00540,ko01100,map00540,map01100 M00064 R05644,R05646 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000,ko01005 - - iECH74115_1262.ECH74115_4363,iECSP_1301.ECSP_4025,iECs_1301.ECs3935,iPC815.YPO0654,iZ_1308.Z4405 CTP_transf_like,PfkB k59_717681_1 1114964.L485_17065 6.45e-47 164.0 COG2124@1|root,COG2124@2|Bacteria,1MY5H@1224|Proteobacteria,2TR6X@28211|Alphaproteobacteria,2K3NE@204457|Sphingomonadales 204457|Sphingomonadales C Cytochrome p450 - - - - - - - - - - - - p450 k59_39785_1 1121035.AUCH01000001_gene1978 2.57e-28 117.0 COG1305@1|root,COG1305@2|Bacteria,1MWCE@1224|Proteobacteria,2VHZP@28216|Betaproteobacteria,2KV42@206389|Rhodocyclales 206389|Rhodocyclales E Domain of unknown function (DUF3488) - - 2.3.2.13 ko:K22452 - - - - ko00000,ko01000 - - - DUF3488,DUF4129,Transglut_core k59_1223958_1 518766.Rmar_1973 5.51e-93 280.0 COG1878@1|root,COG1878@2|Bacteria,4PIWM@976|Bacteroidetes,1FJPB@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes S Putative cyclase - GO:0003674,GO:0003824,GO:0004061,GO:0006082,GO:0006520,GO:0006568,GO:0006569,GO:0006576,GO:0006586,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009072,GO:0009074,GO:0009308,GO:0009310,GO:0009987,GO:0016054,GO:0016787,GO:0016810,GO:0016811,GO:0019439,GO:0019441,GO:0019752,GO:0032787,GO:0034641,GO:0042180,GO:0042402,GO:0042430,GO:0042436,GO:0042537,GO:0043420,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0046218,GO:0046395,GO:0046483,GO:0046700,GO:0070189,GO:0071704,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 3.5.1.9 ko:K07130 ko00380,ko00630,ko01100,map00380,map00630,map01100 M00038 R00988,R01959,R04911 RC00263,RC00323 ko00000,ko00001,ko00002,ko01000 - - - Cyclase k59_541386_1 1125863.JAFN01000001_gene1028 1.27e-141 422.0 COG0480@1|root,COG0480@2|Bacteria,1MUCV@1224|Proteobacteria,42NDG@68525|delta/epsilon subdivisions,2WKYU@28221|Deltaproteobacteria 28221|Deltaproteobacteria J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome fusA1 - - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2 k59_717712_1 1443665.JACA01000064_gene4778 2.76e-101 315.0 COG3537@1|root,COG3537@2|Bacteria,4NDYB@976|Bacteroidetes,1HWR3@117743|Flavobacteriia,2YHGE@290174|Aquimarina 976|Bacteroidetes G Glycosyl hydrolase family 92 - - - - - - - - - - - - Glyco_hydro_92 k59_1333964_1 436308.Nmar_0726 1.64e-82 260.0 COG0553@1|root,arCOG00883@2157|Archaea,41T0G@651137|Thaumarchaeota 651137|Thaumarchaeota K SNF2 family N-terminal domain - - - - - - - - - - - - Helicase_C,SNF2_N k59_768757_1 1279017.AQYJ01000029_gene3744 5.6e-78 239.0 COG0670@1|root,COG0670@2|Bacteria,1MU69@1224|Proteobacteria,1RRVZ@1236|Gammaproteobacteria,4653K@72275|Alteromonadaceae 1236|Gammaproteobacteria S Belongs to the BI1 family yccA GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0016021,GO:0019222,GO:0030162,GO:0031224,GO:0044425,GO:0044464,GO:0050789,GO:0051171,GO:0051246,GO:0060255,GO:0065007,GO:0071944,GO:0080090 - ko:K19416 - M00742 - - ko00000,ko00002,ko02000 1.A.14.2.1 - - Bax1-I k59_1333966_2 1207063.P24_03301 1.43e-36 140.0 COG1674@1|root,COG1674@2|Bacteria,1MVPI@1224|Proteobacteria,2TR48@28211|Alphaproteobacteria,2JPF3@204441|Rhodospirillales 204441|Rhodospirillales D COG1674 DNA segregation ATPase FtsK SpoIIIE and related proteins ftsK - - ko:K03466 - - - - ko00000,ko03036 3.A.12 - - FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma k59_768760_1 1144305.PMI02_00846 1.17e-115 345.0 COG2211@1|root,COG2211@2|Bacteria,1MVUM@1224|Proteobacteria,2U8DJ@28211|Alphaproteobacteria,2K102@204457|Sphingomonadales 204457|Sphingomonadales G MFS/sugar transport protein - - - ko:K03292 - - - - ko00000 2.A.2 - - MFS_2 k59_717719_1 1117647.M5M_13590 1.88e-58 202.0 COG3119@1|root,COG3119@2|Bacteria,1MV92@1224|Proteobacteria,1RPDE@1236|Gammaproteobacteria,1J8XH@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P COG3119 Arylsulfatase A and related enzymes - - 3.1.6.1 ko:K01130 ko00140,ko00600,map00140,map00600 - R03980,R04856 RC00128,RC00231 ko00000,ko00001,ko01000 - - - Sulfatase k59_1566514_1 1088721.NSU_3635 3.4e-20 84.0 COG3384@1|root,COG3384@2|Bacteria,1RIBC@1224|Proteobacteria,2UET5@28211|Alphaproteobacteria,2KA6Q@204457|Sphingomonadales 204457|Sphingomonadales S Aromatic-ring-opening dioxygenase LigAB, LigA subunit - - 1.13.11.8 ko:K04100 ko00362,ko00624,ko00627,ko01120,map00362,map00624,map00627,map01120 - R01632,R03550,R04280,R09565 RC00233,RC00387,RC00535,RC02567,RC02694 br01602,ko00000,ko00001,ko01000 - - - LigA k59_1566514_2 1088721.NSU_3634 1.71e-82 249.0 COG3384@1|root,COG3384@2|Bacteria,1MW77@1224|Proteobacteria,2TRP1@28211|Alphaproteobacteria,2K8TJ@204457|Sphingomonadales 204457|Sphingomonadales C Catalytic LigB subunit of aromatic ring-opening dioxygenase - - 1.13.11.8 ko:K04101 ko00362,ko00624,ko00627,ko01120,map00362,map00624,map00627,map01120 - R01632,R03550,R04280,R09565 RC00233,RC00387,RC00535,RC02567,RC02694 br01602,ko00000,ko00001,ko01000 - - - LigB k59_1673787_1 448385.sce4706 2.04e-58 194.0 COG5557@1|root,COG5557@2|Bacteria,1PFX4@1224|Proteobacteria,42NUN@68525|delta/epsilon subdivisions,2WJHN@28221|Deltaproteobacteria,2YWI0@29|Myxococcales 28221|Deltaproteobacteria C Polysulphide reductase, NrfD - - - ko:K00185 - - - - ko00000 5.A.3 - - NrfD k59_1673790_1 521045.Kole_1879 3.29e-19 80.9 COG0361@1|root,COG0361@2|Bacteria,2GD78@200918|Thermotogae 200918|Thermotogae J One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex infA GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0043021,GO:0043022,GO:0044424,GO:0044444,GO:0044464,GO:0044877 - ko:K02518 - - - - ko00000,ko03012 - - - eIF-1a k59_1277146_1 903818.KI912268_gene1508 7.24e-26 107.0 COG0745@1|root,COG4191@1|root,COG0745@2|Bacteria,COG4191@2|Bacteria,3Y3MW@57723|Acidobacteria 57723|Acidobacteria T Histidine kinase-like ATPases - - - - - - - - - - - - HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_8,Response_reg k59_887903_1 392499.Swit_3706 2.73e-57 193.0 COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,2TR2P@28211|Alphaproteobacteria,2KEBC@204457|Sphingomonadales 204457|Sphingomonadales V ABC transporter - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_887903_2 1304275.C41B8_10620 9.13e-59 194.0 COG0842@1|root,COG0842@2|Bacteria,1MW5R@1224|Proteobacteria,1RPB4@1236|Gammaproteobacteria 1236|Gammaproteobacteria V ABC-type multidrug transport system, permease component ybhS GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006855,GO:0008150,GO:0015562,GO:0015893,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0042221,GO:0042493,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071944 - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_2,ABC2_membrane_3 k59_1167985_1 631454.N177_2660 2.23e-25 110.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,2TQR7@28211|Alphaproteobacteria,1JQ4H@119043|Rhodobiaceae 28211|Alphaproteobacteria NT Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - HAMP,MCPsignal,sCache_2,sCache_3_3 k59_1673804_1 504487.JCM19302_1023 6.9e-25 100.0 COG4206@1|root,COG4206@2|Bacteria,4NHH8@976|Bacteroidetes,1HYTZ@117743|Flavobacteriia 976|Bacteroidetes H TonB-dependent receptor btuB - - ko:K16092 - - - - ko00000,ko02000 1.B.14.3 - - Plug,TonB_dep_Rec k59_1673804_2 1469557.JSWF01000025_gene1364 9.16e-19 87.4 COG0793@1|root,COG0793@2|Bacteria,4NFKJ@976|Bacteroidetes,1HXNC@117743|Flavobacteriia 976|Bacteroidetes M peptidase S41 - - - - - - - - - - - - Peptidase_S41 k59_827605_2 593750.Metfor_1550 6.42e-69 215.0 COG1432@1|root,arCOG02408@2157|Archaea 2157|Archaea S NYN domain - - - - - - - - - - - - NYN,OST-HTH k59_46886_1 1209072.ALBT01000032_gene1917 6.65e-130 387.0 COG3104@1|root,COG3104@2|Bacteria,1MW6W@1224|Proteobacteria,1RM8P@1236|Gammaproteobacteria 1236|Gammaproteobacteria U Proton-dependent permease that transports di- and tripeptides - - - ko:K03305 - - - - ko00000 2.A.17 - - PTR2 k59_725435_1 87626.PTD2_14747 6.09e-32 124.0 COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,1RMDA@1236|Gammaproteobacteria,2Q1MF@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria MU COG1538 Outer membrane protein - - - - - - - - - - - - OEP k59_1454936_1 1229909.NSED_00680 1.67e-151 432.0 COG0604@1|root,arCOG01458@2157|Archaea,41SX7@651137|Thaumarchaeota 651137|Thaumarchaeota C Zinc-binding dehydrogenase - - - - - - - - - - - - ADH_N,ADH_zinc_N k59_725443_1 515620.EUBELI_01161 2.02e-27 113.0 COG1104@1|root,COG1104@2|Bacteria,1TP21@1239|Firmicutes,24888@186801|Clostridia,25V3Y@186806|Eubacteriaceae 186801|Clostridia E Psort location Cytoplasmic, score iscS - 2.8.1.7 ko:K04487 ko00730,ko01100,ko04122,map00730,map01100,map04122 - R07460,R11528,R11529 RC01789,RC02313 ko00000,ko00001,ko01000,ko02048,ko03016,ko03029 - - - Aminotran_5 k59_895592_1 1379698.RBG1_1C00001G1319 3.55e-41 150.0 COG0438@1|root,COG0438@2|Bacteria 2|Bacteria M transferase activity, transferring glycosyl groups - - - - - - - - - - - - Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1 k59_725444_1 1121403.AUCV01000051_gene2131 1.11e-42 159.0 COG3264@1|root,COG3264@2|Bacteria,1MWSA@1224|Proteobacteria,42N78@68525|delta/epsilon subdivisions,2WM0M@28221|Deltaproteobacteria,2MHVS@213118|Desulfobacterales 28221|Deltaproteobacteria M Mechanosensitive ion channel - - - ko:K05802 - - - - ko00000,ko02000 1.A.23.1.1 - - MS_channel k59_946324_1 436308.Nmar_1500 2.17e-133 379.0 arCOG08676@1|root,arCOG08676@2157|Archaea,41SCF@651137|Thaumarchaeota 651137|Thaumarchaeota C Archaeal ammonia monooxygenase subunit A (AmoA) - - 1.14.18.3,1.14.99.39 ko:K10944 ko00680,ko00910,ko01100,ko01120,ko01200,map00680,map00910,map01100,map01120,map01200 M00174,M00528,M00804 R00148,R09518 RC00173,RC02797 ko00000,ko00001,ko00002,ko01000 - - - Archaeal_AmoA k59_835075_1 997884.HMPREF1068_04405 1.12e-49 168.0 2DM9D@1|root,328C5@2|Bacteria,4NPRC@976|Bacteroidetes,2FRTC@200643|Bacteroidia,4AMP2@815|Bacteroidaceae 976|Bacteroidetes S COG NOG37815 non supervised orthologous group - - - - - - - - - - - - DDE_Tnp_1 k59_387172_1 1049564.TevJSym_ac01890 7.01e-138 406.0 COG1160@1|root,COG1160@2|Bacteria,1MU9S@1224|Proteobacteria,1RMSF@1236|Gammaproteobacteria,1J4NG@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S GTPase that plays an essential role in the late steps of ribosome biogenesis der GO:0000027,GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005515,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006996,GO:0008150,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0022607,GO:0022613,GO:0022618,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0032794,GO:0034622,GO:0035639,GO:0036094,GO:0042254,GO:0042255,GO:0042273,GO:0043021,GO:0043022,GO:0043023,GO:0043167,GO:0043168,GO:0043933,GO:0044085,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:0097159,GO:0097216,GO:0097367,GO:1901265,GO:1901363 - ko:K03977 - - - - ko00000,ko03009 - - - KH_dom-like,MMR_HSR1 k59_387172_2 1385515.N791_12465 7.68e-79 248.0 COG2021@1|root,COG2021@2|Bacteria,1MVJV@1224|Proteobacteria,1RQ2N@1236|Gammaproteobacteria,1X47D@135614|Xanthomonadales 135614|Xanthomonadales E Transfers a succinyl group from succinyl-CoA to L- serine, forming succinyl-L-serine metX GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004414,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008374,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009086,GO:0009092,GO:0009987,GO:0016053,GO:0016407,GO:0016413,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.3.1.31 ko:K00641 ko00270,ko01100,ko01130,map00270,map01100,map01130 - R01776 RC00004,RC00041 ko00000,ko00001,ko01000 - - - Abhydrolase_1 k59_1002116_1 1088721.NSU_0195 3.98e-106 324.0 COG0367@1|root,COG0367@2|Bacteria,1MW4E@1224|Proteobacteria,2TSCY@28211|Alphaproteobacteria,2JZZC@204457|Sphingomonadales 204457|Sphingomonadales E Asparagine synthase asnB - 6.3.5.4 ko:K01953 ko00250,ko01100,ko01110,map00250,map01100,map01110 - R00578 RC00010 ko00000,ko00001,ko01000,ko01002 - - - Asn_synthase,GATase_7 k59_1454946_1 1137281.D778_00666 2.21e-141 427.0 COG1520@1|root,COG1520@2|Bacteria,4NHQ3@976|Bacteroidetes,1HZ3X@117743|Flavobacteriia 976|Bacteroidetes S Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane - - - - - - - - - - - - DUF3352 k59_46905_1 1122137.AQXF01000003_gene1892 1.35e-184 522.0 COG1360@1|root,COG1360@2|Bacteria,1MU4S@1224|Proteobacteria,2TQKZ@28211|Alphaproteobacteria 28211|Alphaproteobacteria N flagellar motor protein MA20_18060 - - ko:K02557 ko02030,ko02040,map02030,map02040 - - - ko00000,ko00001,ko02000,ko02035 1.A.30.1 - - OmpA k59_46905_3 1122137.AQXF01000003_gene1893 7.37e-88 268.0 COG0834@1|root,COG0834@2|Bacteria,1PWW3@1224|Proteobacteria,2UJKH@28211|Alphaproteobacteria 28211|Alphaproteobacteria ET Bacterial extracellular solute-binding proteins, family 3 - - - - - - - - - - - - SBP_bac_3 k59_946363_1 159450.NH14_28040 5.74e-23 102.0 COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,2VI5V@28216|Betaproteobacteria,1K1DV@119060|Burkholderiaceae 28216|Betaproteobacteria MU TIGRFAM RND efflux system, outer membrane lipoprotein, NodT family - - - ko:K18139 ko01501,ko02024,map01501,map02024 M00642,M00643,M00647,M00718,M00768,M00822 - - ko00000,ko00001,ko00002,ko01504,ko02000 1.B.17,2.A.6.2 - - OEP k59_1516675_1 768670.Calni_0414 0.000145 46.6 COG3210@1|root,COG3210@2|Bacteria 2|Bacteria U domain, Protein - - - ko:K12287,ko:K12548 - - - - ko00000,ko02044 - - - VPEP k59_1516675_2 397278.JOJN01000002_gene709 5.58e-08 54.3 COG1274@1|root,COG1274@2|Bacteria,2GJH3@201174|Actinobacteria,4DN6G@85009|Propionibacteriales 201174|Actinobacteria H Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle pckG - 4.1.1.32 ko:K01596 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko03320,ko04068,ko04151,ko04152,ko04910,ko04920,ko04922,ko04931,ko04964,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map03320,map04068,map04151,map04152,map04910,map04920,map04922,map04931,map04964 M00003 R00431,R00726 RC00002,RC02741 ko00000,ko00001,ko00002,ko01000 - - - PEPCK_C,PEPCK_N k59_1404163_1 1122137.AQXF01000008_gene3450 2.02e-142 428.0 COG3914@1|root,COG3914@2|Bacteria 2|Bacteria O protein N-acetylglucosaminyltransferase activity - - - - - - - - - - - - Glyco_transf_41 k59_1063399_1 767434.Fraau_2684 3.13e-84 270.0 COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,1RMFF@1236|Gammaproteobacteria,1X3MV@135614|Xanthomonadales 135614|Xanthomonadales C dehydrogenase lpdA - 1.8.1.4 ko:K00382 ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00036,M00307,M00532 R00209,R01221,R01698,R03815,R07618,R08549 RC00004,RC00022,RC00583,RC02742,RC02833,RC02834 br01601,ko00000,ko00001,ko00002,ko01000,ko04147 - - - Biotin_lipoyl,Pyr_redox_2,Pyr_redox_dim k59_1626881_1 211114.JOEF01000013_gene4910 1.38e-17 85.1 COG2267@1|root,COG2267@2|Bacteria,2I8UI@201174|Actinobacteria 201174|Actinobacteria I Alpha beta hydrolase - - - - - - - - - - - - Abhydrolase_6,Hydrolase_4 k59_895628_1 378806.STAUR_5300 2.34e-33 136.0 COG4412@1|root,COG4412@2|Bacteria,1R3SG@1224|Proteobacteria,42SZZ@68525|delta/epsilon subdivisions,2WPD0@28221|Deltaproteobacteria,2YUKS@29|Myxococcales 28221|Deltaproteobacteria E Fungalysin metallopeptidase (M36) - - - - - - - - - - - - PA,Peptidase_M36,REJ k59_1116230_1 570952.ATVH01000011_gene353 1.54e-33 135.0 2EXSU@1|root,33R23@2|Bacteria,1NS77@1224|Proteobacteria,2UR4M@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_612321_1 1323663.AROI01000008_gene2633 1.31e-41 147.0 COG0715@1|root,COG0715@2|Bacteria,1MW53@1224|Proteobacteria,1RVY8@1236|Gammaproteobacteria 1236|Gammaproteobacteria P NMT1-like family - - - ko:K02051 - M00188 - - ko00000,ko00002,ko02000 3.A.1.16,3.A.1.17 - - NMT1 k59_214624_1 861299.J421_5794 2.09e-99 315.0 COG0515@1|root,COG0515@2|Bacteria,1ZUMJ@142182|Gemmatimonadetes 142182|Gemmatimonadetes KLT Protein kinase domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - PD40,Pkinase k59_895643_1 1437448.AZRT01000127_gene271 1.08e-49 171.0 COG3931@1|root,COG3931@2|Bacteria,1QI71@1224|Proteobacteria,2VGUT@28211|Alphaproteobacteria,1J1TS@118882|Brucellaceae 28211|Alphaproteobacteria E N-formylglutamate amidohydrolase - - - - - - - - - - - - FGase k59_895643_2 1121015.N789_10105 1.5e-89 293.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1X3Q4@135614|Xanthomonadales 135614|Xanthomonadales T GGDEF domain - - - - - - - - - - - - CHASE,EAL,GGDEF k59_1682109_1 1122137.AQXF01000003_gene2346 6.77e-202 579.0 COG0515@1|root,COG0515@2|Bacteria,1R4I9@1224|Proteobacteria,2U0GX@28211|Alphaproteobacteria 28211|Alphaproteobacteria KLT COG0515 Serine threonine protein kinase - - - - - - - - - - - - Pkinase k59_1174992_1 1229909.NSED_06060 6.34e-18 82.0 COG1250@1|root,arCOG00249@2157|Archaea,41S92@651137|Thaumarchaeota 651137|Thaumarchaeota I 3-hydroxyacyl-CoA dehydrogenase - - 1.1.1.35,4.2.1.17 ko:K15016 ko00720,ko01120,ko01200,map00720,map01120,map01200 M00374,M00375 R01975,R03026 RC00117,RC00831 ko00000,ko00001,ko00002,ko01000 - - - 3HCDH,3HCDH_N k59_1174992_2 436308.Nmar_1030 2.28e-68 211.0 COG1611@1|root,arCOG02431@2157|Archaea,41SMW@651137|Thaumarchaeota 651137|Thaumarchaeota S Rossmann fold nucleotide-binding protein - - 3.2.2.10 ko:K06966 ko00230,ko00240,map00230,map00240 - R00182,R00510 RC00063,RC00318 ko00000,ko00001,ko01000 - - - Lysine_decarbox k59_1116238_1 1122134.KB893650_gene584 9.21e-137 410.0 COG1297@1|root,COG1297@2|Bacteria,1N7SK@1224|Proteobacteria,1RNC8@1236|Gammaproteobacteria,1XP2X@135619|Oceanospirillales 135619|Oceanospirillales S OPT oligopeptide transporter protein - - - - - - - - - - - - OPT k59_330367_2 1265505.ATUG01000002_gene2539 1.01e-33 122.0 2AT0I@1|root,31IGD@2|Bacteria,1NAE0@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_1682118_1 1268622.AVS7_03071 1.19e-11 66.6 COG0491@1|root,COG0491@2|Bacteria,1MUXF@1224|Proteobacteria,2VKJX@28216|Betaproteobacteria,4AAKM@80864|Comamonadaceae 28216|Betaproteobacteria S PFAM beta-lactamase domain protein - - - - - - - - - - - - Lactamase_B k59_1682118_2 1122137.AQXF01000002_gene506 1.05e-50 177.0 COG1960@1|root,COG1960@2|Bacteria,1MU20@1224|Proteobacteria,2TQJS@28211|Alphaproteobacteria 28211|Alphaproteobacteria I acyl-CoA dehydrogenase mmgC GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016627,GO:0036094,GO:0043167,GO:0043168,GO:0048037,GO:0050660,GO:0050662,GO:0052890,GO:0055114,GO:0097159,GO:1901265,GO:1901363 1.3.8.1,1.3.8.7 ko:K00248,ko:K00249,ko:K20035 ko00071,ko00280,ko00410,ko00640,ko00650,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map00650,map00920,map01100,map01110,map01120,map01130,map01200,map01212,map03320 M00013,M00036,M00087 R00924,R01175,R01178,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754,R11130 RC00052,RC00068,RC00076,RC00095,RC00120,RC00148,RC00246,RC03363 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_C,Acyl-CoA_dh_M,Acyl-CoA_dh_N,AcylCoA_DH_N k59_1404202_2 1088721.NSU_0720 6.23e-145 429.0 COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,1MWGR@1224|Proteobacteria,2TRTE@28211|Alphaproteobacteria,2K0PD@204457|Sphingomonadales 204457|Sphingomonadales EU Prolyl oligopeptidase family - - - - - - - - - - - - PD40,Peptidase_S9 k59_1404216_1 702113.PP1Y_AT1221 8.36e-116 340.0 COG2008@1|root,COG2008@2|Bacteria,1MWCR@1224|Proteobacteria,2TSUA@28211|Alphaproteobacteria,2K0EJ@204457|Sphingomonadales 204457|Sphingomonadales E Threonine aldolase ltaA - 4.1.2.48 ko:K01620 ko00260,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map01100,map01110,map01120,map01130,map01230 - R00751,R06171 RC00312,RC00372 ko00000,ko00001,ko01000 - - - Beta_elim_lyase k59_157397_1 236097.ADG881_2065 8.27e-67 210.0 COG2885@1|root,COG2885@2|Bacteria,1MYBP@1224|Proteobacteria,1RVRF@1236|Gammaproteobacteria,1XJH9@135619|Oceanospirillales 135619|Oceanospirillales M Belongs to the ompA family - - - ko:K03286 - - - - ko00000,ko02000 1.B.6 - - Gly-zipper_Omp,OMP_b-brl,OmpA k59_46963_1 306281.AJLK01000073_gene2611 0.000387 48.1 COG0515@1|root,COG2319@1|root,COG0515@2|Bacteria,COG2319@2|Bacteria,1G1MB@1117|Cyanobacteria,1JHNY@1189|Stigonemataceae 1117|Cyanobacteria KLT Protein tyrosine kinase - - - - - - - - - - - - GUN4,Pkinase,WD40 k59_1682141_1 1122137.AQXF01000005_gene1306 7.47e-145 439.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2TQT0@28211|Alphaproteobacteria 28211|Alphaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_613442_1 391625.PPSIR1_16130 6.26e-64 210.0 COG3039@1|root,COG3039@2|Bacteria,1R70H@1224|Proteobacteria,42Y58@68525|delta/epsilon subdivisions,2WTVD@28221|Deltaproteobacteria 28221|Deltaproteobacteria L Transposase domain (DUF772) - - - ko:K07487 - - - - ko00000 - - - DDE_Tnp_1,DUF772 k59_665632_1 1038922.PflQ2_4495 1.69e-08 54.3 COG1104@1|root,COG1104@2|Bacteria,1MU1C@1224|Proteobacteria,1RNCD@1236|Gammaproteobacteria,1YM8Z@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria H Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins iscS GO:0001522,GO:0003674,GO:0003824,GO:0004123,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006790,GO:0006807,GO:0008033,GO:0008144,GO:0008150,GO:0008152,GO:0008483,GO:0009000,GO:0009058,GO:0009451,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016226,GO:0016740,GO:0016769,GO:0016782,GO:0016783,GO:0016829,GO:0016846,GO:0018130,GO:0018131,GO:0019842,GO:0022607,GO:0030170,GO:0031071,GO:0031119,GO:0031163,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046484,GO:0048037,GO:0050662,GO:0051186,GO:0070279,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0097163,GO:0140104,GO:1901360,GO:1901363 2.8.1.7 ko:K04487 ko00730,ko01100,ko04122,map00730,map01100,map04122 - R07460,R11528,R11529 RC01789,RC02313 ko00000,ko00001,ko01000,ko02048,ko03016,ko03029 - - iPC815.YPO2896,iYL1228.KPN_02862 Aminotran_5 k59_665632_2 864051.BurJ1DRAFT_1009 1.53e-67 208.0 COG0822@1|root,COG0822@2|Bacteria,1RD5K@1224|Proteobacteria,2VQ2I@28216|Betaproteobacteria,1KKKU@119065|unclassified Burkholderiales 28216|Betaproteobacteria C A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters iscU - - ko:K04488 - - - - ko00000 - - - NifU_N k59_726665_1 1280949.HAD_04005 6.82e-30 121.0 COG2159@1|root,COG2159@2|Bacteria,1P6G6@1224|Proteobacteria,2TU10@28211|Alphaproteobacteria 28211|Alphaproteobacteria S metal-dependent hydrolase of the TIM-barrel fold - - - - - - - - - - - - Amidohydro_2 k59_665641_1 983545.Glaag_3947 6.03e-48 168.0 COG3182@1|root,COG3182@2|Bacteria,1MVET@1224|Proteobacteria,1RY6J@1236|Gammaproteobacteria,465II@72275|Alteromonadaceae 1236|Gammaproteobacteria S PepSY-associated TM region - - - - - - - - - - - - PepSY_TM k59_1286475_1 702113.PP1Y_AT36909 4.99e-72 222.0 COG0396@1|root,COG0396@2|Bacteria,1MUGK@1224|Proteobacteria,2TS8T@28211|Alphaproteobacteria,2K0E3@204457|Sphingomonadales 204457|Sphingomonadales O ABC-type transport system involved in Fe-S cluster assembly, ATPase component sufC - - ko:K09013 - - - - ko00000,ko02000 - - - ABC_tran k59_776948_1 1177181.T9A_02261 1.07e-13 71.6 COG0617@1|root,COG0617@2|Bacteria,1MVCS@1224|Proteobacteria,1RMBG@1236|Gammaproteobacteria,1XHIH@135619|Oceanospirillales 135619|Oceanospirillales J Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control pcnB - 2.7.7.19 ko:K00970 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - PolyA_pol,PolyA_pol_RNAbd,PolyA_pol_arg_C k59_776948_2 317025.Tcr_1527 2.24e-36 129.0 COG0801@1|root,COG0801@2|Bacteria,1MZH8@1224|Proteobacteria,1S63J@1236|Gammaproteobacteria,460YW@72273|Thiotrichales 72273|Thiotrichales H PFAM 7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK - - 2.7.6.3 ko:K00950 ko00790,ko01100,map00790,map01100 M00126,M00841 R03503 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - HPPK k59_273696_1 1254432.SCE1572_16000 2.91e-07 55.8 COG3386@1|root,COG3386@2|Bacteria,1QUU9@1224|Proteobacteria,42ZTS@68525|delta/epsilon subdivisions,2WVGZ@28221|Deltaproteobacteria,2YZAH@29|Myxococcales 28221|Deltaproteobacteria G PFAM SMP-30 Gluconolaconase - - - - - - - - - - - - - k59_896811_1 1144319.PMI16_04763 1.72e-20 88.2 COG0066@1|root,COG0066@2|Bacteria,1MVXB@1224|Proteobacteria,2VIJC@28216|Betaproteobacteria,472UP@75682|Oxalobacteraceae 28216|Betaproteobacteria E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate leuD - 4.2.1.33,4.2.1.35 ko:K01704 ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230 M00432,M00535 R03896,R03898,R03968,R04001,R10170 RC00976,RC00977,RC01041,RC01046,RC03072 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase_C k59_896811_2 1397527.Q670_05435 2.13e-59 194.0 COG0136@1|root,COG0136@2|Bacteria,1MUHG@1224|Proteobacteria,1RMN3@1236|Gammaproteobacteria,1XHYW@135619|Oceanospirillales 135619|Oceanospirillales E Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate asd - 1.2.1.11 ko:K00133 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00017,M00018,M00033,M00525,M00526,M00527 R02291 RC00684 ko00000,ko00001,ko00002,ko01000 - - - Semialdhyde_dh,Semialdhyde_dhC k59_1286490_1 1441629.PCH70_22560 5.18e-48 172.0 COG1429@1|root,COG1429@2|Bacteria,1MU5W@1224|Proteobacteria,1RQED@1236|Gammaproteobacteria,1Z5FS@136849|Pseudomonas syringae group 1236|Gammaproteobacteria H CobN/Magnesium Chelatase cobN - 6.6.1.2 ko:K02230 ko00860,ko01100,map00860,map01100 - R05227 RC02000 ko00000,ko00001,ko01000 - - - CobN-Mg_chel k59_1286490_2 342113.DM82_1285 4.13e-24 100.0 COG1239@1|root,COG1239@2|Bacteria,1MVD4@1224|Proteobacteria,2VJ2U@28216|Betaproteobacteria,1K2XC@119060|Burkholderiaceae 28216|Betaproteobacteria H magnesium chelatase - - 6.6.1.1 ko:K03404,ko:K03405 ko00860,ko01100,ko01110,map00860,map01100,map01110 - R03877 RC01012 ko00000,ko00001,ko01000 - - - AAA_5,Mg_chelatase,VWA_2 k59_550376_2 1205910.B005_3607 1.11e-14 75.5 COG0484@1|root,COG0484@2|Bacteria,2GK69@201174|Actinobacteria,4EGSJ@85012|Streptosporangiales 201174|Actinobacteria O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins dnaJ GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0030312,GO:0040007,GO:0044464,GO:0071944 - ko:K03686 - - - - ko00000,ko03029,ko03110 - - - DnaJ,DnaJ_C,DnaJ_CXXCXGXG k59_331413_1 1194972.MVAC_22975 1.07e-42 149.0 COG1028@1|root,COG1028@2|Bacteria,2IG96@201174|Actinobacteria,23D9I@1762|Mycobacteriaceae 201174|Actinobacteria IQ KR domain - - - - - - - - - - - - adh_short_C2 k59_550385_1 404380.Gbem_1031 1.42e-69 233.0 COG0855@1|root,COG0855@2|Bacteria,1MUM3@1224|Proteobacteria,42NN7@68525|delta/epsilon subdivisions,2WJG7@28221|Deltaproteobacteria,43STK@69541|Desulfuromonadales 28221|Deltaproteobacteria H Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) ppk - 2.7.4.1 ko:K00937 ko00190,ko03018,map00190,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - PP_kinase,PP_kinase_C,PP_kinase_N k59_1176085_1 436308.Nmar_0066 3.91e-80 248.0 COG1467@1|root,arCOG04110@2157|Archaea,41SCB@651137|Thaumarchaeota 651137|Thaumarchaeota L Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair priS - - ko:K02683 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - DNA_primase_S k59_1456265_1 1306947.ARQD01000005_gene54 3.07e-85 275.0 COG0209@1|root,COG0209@2|Bacteria,2NNRM@2323|unclassified Bacteria 2|Bacteria F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides nrdA GO:0000166,GO:0003674,GO:0003824,GO:0004748,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005971,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009262,GO:0009263,GO:0009987,GO:0016491,GO:0016725,GO:0016728,GO:0018130,GO:0019438,GO:0019637,GO:0032991,GO:0034641,GO:0034654,GO:0036094,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046483,GO:0055086,GO:0055114,GO:0061731,GO:0071704,GO:0090407,GO:0097159,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902494,GO:1990204 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - ATP-cone,Ribonuc_red_lgC,Ribonuc_red_lgN k59_1342734_1 1232410.KI421424_gene1860 7.86e-14 69.7 COG1100@1|root,COG1100@2|Bacteria,1R6NS@1224|Proteobacteria,42NIX@68525|delta/epsilon subdivisions,2WJ44@28221|Deltaproteobacteria,43RZJ@69541|Desulfuromonadales 28221|Deltaproteobacteria S ADP-ribosylation factor family mglA - - ko:K06883 - - - - ko00000 - - - Arf,Ras k59_1064561_1 314225.ELI_09035 1.36e-56 191.0 COG0591@1|root,COG0591@2|Bacteria,1MUBI@1224|Proteobacteria,2VF3C@28211|Alphaproteobacteria,2KDVP@204457|Sphingomonadales 204457|Sphingomonadales E Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family - - - ko:K03307 - - - - ko00000 2.A.21 - - SSF k59_1064567_1 998674.ATTE01000001_gene2636 3.66e-102 310.0 COG0397@1|root,COG0397@2|Bacteria,1MVK3@1224|Proteobacteria,1RNCS@1236|Gammaproteobacteria,460BH@72273|Thiotrichales 72273|Thiotrichales S Uncharacterized ACR, YdiU/UPF0061 family - - - - - - - - - - - - UPF0061 k59_1627916_1 1415778.JQMM01000001_gene633 1.18e-46 159.0 COG1561@1|root,COG1561@2|Bacteria,1MWRA@1224|Proteobacteria,1RMAB@1236|Gammaproteobacteria,1J4QV@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S stress-induced protein yicC GO:0000175,GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004532,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008408,GO:0009022,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016072,GO:0016075,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016796,GO:0016896,GO:0019439,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0140098,GO:0140101,GO:1901360,GO:1901361,GO:1901575 - - - - - - - - - - DUF1732,YicC_N k59_1517806_1 1455608.JDTH01000002_gene390 3.08e-08 60.8 arCOG06227@1|root,arCOG06227@2157|Archaea,2XVPI@28890|Euryarchaeota,23UUI@183963|Halobacteria 183963|Halobacteria S Domain of unknown function (DUF4397) - - - - - - - - - - - - DUF4397 k59_1286527_1 861299.J421_0695 2.64e-09 63.2 COG0577@1|root,COG0577@2|Bacteria 2|Bacteria V efflux transmembrane transporter activity - - - - - - - - - - - - FtsX,MacB_PCD k59_1064569_2 457396.CSBG_00987 1.76e-47 166.0 COG2133@1|root,COG2133@2|Bacteria,1TR38@1239|Firmicutes,248E0@186801|Clostridia,36DXQ@31979|Clostridiaceae 186801|Clostridia G Glucose sorbosone - - - - - - - - - - - - GSDH k59_1342749_2 1229909.NSED_05155 2.05e-59 183.0 COG4830@1|root,arCOG04305@2157|Archaea,41SNM@651137|Thaumarchaeota 651137|Thaumarchaeota J ribosomal protein - - - ko:K02976 ko03010,map03010 M00177,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S26e k59_550430_1 570952.ATVH01000001_gene902 7.89e-56 198.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2TQT0@28211|Alphaproteobacteria,2JRMJ@204441|Rhodospirillales 204441|Rhodospirillales V AcrB/AcrD/AcrF family - - - - - - - - - - - - ACR_tran k59_1575196_1 880073.Calab_2882 1.09e-48 175.0 COG0067@1|root,COG0069@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,2NP08@2323|unclassified Bacteria 2|Bacteria E Glutamate synthase central domain gltB GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006541,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0015930,GO:0016053,GO:0016491,GO:0016638,GO:0019676,GO:0019740,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.4.1.13,1.4.1.14,1.4.7.1 ko:K00265,ko:K00284 ko00250,ko00630,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00630,map00910,map01100,map01110,map01120,map01130,map01230 - R00021,R00093,R00114,R00248,R10086 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - GATase_2,GXGXG,Glu_syn_central,Glu_synthase k59_1575196_2 330214.NIDE3383 1.11e-195 559.0 COG0493@1|root,COG0493@2|Bacteria,3J152@40117|Nitrospirae 40117|Nitrospirae C Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster - - 1.4.1.13,1.4.1.14 ko:K00266 ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 - R00093,R00114,R00248 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - Fer4,Fer4_20,GXGXG,Pyr_redox_2,Pyr_redox_3 k59_439325_1 338963.Pcar_2557 4.52e-58 201.0 COG0744@1|root,COG0744@2|Bacteria,1QTST@1224|Proteobacteria,42Q00@68525|delta/epsilon subdivisions,2WJEM@28221|Deltaproteobacteria,43UHA@69541|Desulfuromonadales 28221|Deltaproteobacteria M Bifunctional transglycosylase second domain mrcB - 2.4.1.129,3.4.16.4 ko:K05365 ko00550,map00550 - R04519 RC00005,RC00049 ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 - Transgly,Transpeptidase,UB2H k59_1575198_1 47839.CCAU010000017_gene3828 9.08e-65 205.0 COG0451@1|root,COG0451@2|Bacteria,2I9DG@201174|Actinobacteria,237C3@1762|Mycobacteriaceae 201174|Actinobacteria GM NAD dependent epimerase dehydratase family - - - - - - - - - - - - Epimerase k59_1456270_1 1296415.JACC01000020_gene3818 4.14e-49 177.0 COG2374@1|root,COG2374@2|Bacteria,4PKDU@976|Bacteroidetes,1IJ8H@117743|Flavobacteriia,2YIIA@290174|Aquimarina 976|Bacteroidetes S Endonuclease Exonuclease Phosphatase - - - - - - - - - - - - Exo_endo_phos,LTD k59_1740397_1 85929.N1QGW1 5.53e-18 87.0 COG2897@1|root,KOG1529@2759|Eukaryota,38CX1@33154|Opisthokonta,3NVFN@4751|Fungi,3QQHU@4890|Ascomycota,20123@147541|Dothideomycetes,3MH14@451867|Dothideomycetidae 4751|Fungi V Rhodanese Homology Domain - GO:0002097,GO:0002098,GO:0002143,GO:0003674,GO:0003824,GO:0004792,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016782,GO:0016783,GO:0034227,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360 2.8.1.1,2.8.1.2 ko:K01011 ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122 - R01931,R03105,R03106 RC00214 ko00000,ko00001,ko01000 - - - Rhodanese k59_726736_1 1123072.AUDH01000001_gene3013 7.01e-116 340.0 COG1028@1|root,COG1028@2|Bacteria,1MUFX@1224|Proteobacteria,2TRWN@28211|Alphaproteobacteria,2JRJC@204441|Rhodospirillales 204441|Rhodospirillales IQ Enoyl-(Acyl carrier protein) reductase - - - - - - - - - - - - adh_short_C2 k59_776986_1 298653.Franean1_4696 2.04e-69 224.0 COG1541@1|root,COG1541@2|Bacteria,2IANT@201174|Actinobacteria 201174|Actinobacteria H Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA) - - - - - - - - - - - - - k59_1064573_1 986075.CathTA2_0514 4.55e-50 169.0 COG0290@1|root,COG0290@2|Bacteria,1V1RC@1239|Firmicutes,4HFUS@91061|Bacilli 91061|Bacilli J IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins infC GO:0003674,GO:0003676,GO:0003723,GO:0003743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006413,GO:0006518,GO:0006807,GO:0006996,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016043,GO:0019538,GO:0022411,GO:0032790,GO:0032984,GO:0032988,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903008 - ko:K02520 - - - - ko00000,ko03012,ko03029 - - - IF3_C,IF3_N k59_1064573_2 536227.CcarbDRAFT_2972 1.77e-15 70.5 COG0291@1|root,COG0291@2|Bacteria,1VF5W@1239|Firmicutes,24QJD@186801|Clostridia,36MNG@31979|Clostridiaceae 186801|Clostridia J Belongs to the bacterial ribosomal protein bL35 family rpmI - - ko:K02916 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L35p k59_1064573_3 485915.Dret_0046 4.1e-44 146.0 COG0292@1|root,COG0292@2|Bacteria,1RGU2@1224|Proteobacteria,42REF@68525|delta/epsilon subdivisions,2WQ4F@28221|Deltaproteobacteria,2MBX1@213115|Desulfovibrionales 28221|Deltaproteobacteria J Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit rplT GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015934,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042273,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904 - ko:K02887 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L20 k59_1064573_4 1123073.KB899242_gene1239 1.44e-108 327.0 COG0016@1|root,COG0016@2|Bacteria,1MVD7@1224|Proteobacteria,1RN22@1236|Gammaproteobacteria,1X40X@135614|Xanthomonadales 135614|Xanthomonadales J Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily pheS GO:0003674,GO:0003824,GO:0004812,GO:0004826,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.20 ko:K01889 ko00970,map00970 M00359,M00360 R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Phe_tRNA-synt_N,tRNA-synt_2d k59_1064573_5 1194526.A284_08175 3.93e-17 81.6 COG0072@1|root,COG0072@2|Bacteria,1TP98@1239|Firmicutes,4HAQ9@91061|Bacilli,4GYG8@90964|Staphylococcaceae 91061|Bacilli J Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily pheT GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016070,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494 6.1.1.20 ko:K01890 ko00970,map00970 M00359,M00360 R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - B3_4,B5,FDX-ACB,tRNA_bind k59_1003253_1 1380390.JIAT01000013_gene276 2.31e-73 249.0 COG1703@1|root,COG1884@1|root,COG2185@1|root,COG1703@2|Bacteria,COG1884@2|Bacteria,COG2185@2|Bacteria,2GM65@201174|Actinobacteria,4CS56@84995|Rubrobacteria 84995|Rubrobacteria EI ArgK protein - - 5.4.99.13 ko:K11942 - - - - ko00000,ko01000 - - - ArgK,B12-binding,MM_CoA_mutase k59_1456291_1 1122137.AQXF01000002_gene486 2.71e-14 71.2 COG4221@1|root,COG4221@2|Bacteria,1MW86@1224|Proteobacteria,2TSEM@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Belongs to the short-chain dehydrogenases reductases (SDR) family MA20_04540 - - - - - - - - - - - adh_short k59_1185731_1 1229909.NSED_03795 1.26e-107 322.0 arCOG08801@1|root,arCOG08801@2157|Archaea 2157|Archaea S Metal dependent phosphohydrolases with conserved 'HD' motif. - - - - - - - - - - - - - k59_675355_1 1379270.AUXF01000007_gene1058 3.43e-52 174.0 COG0767@1|root,COG0767@2|Bacteria,1ZUC4@142182|Gemmatimonadetes 142182|Gemmatimonadetes Q Permease MlaE - - - ko:K02066 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - MlaE k59_675355_2 390333.Ldb1245 0.000148 44.3 COG0568@1|root,COG0568@2|Bacteria,1TPD6@1239|Firmicutes,4HB1H@91061|Bacilli,3F9B5@33958|Lactobacillaceae 91061|Bacilli K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released - - - ko:K03086 - - - - ko00000,ko03021 - - - Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4 k59_846569_1 395494.Galf_0840 7.06e-74 236.0 COG0518@1|root,COG0519@1|root,COG0518@2|Bacteria,COG0519@2|Bacteria,1MU2A@1224|Proteobacteria,2VHNG@28216|Betaproteobacteria,44V7R@713636|Nitrosomonadales 28216|Betaproteobacteria F Catalyzes the synthesis of GMP from XMP guaA - 6.3.5.2 ko:K01951 ko00230,ko00983,ko01100,map00230,map00983,map01100 M00050 R01230,R01231,R08244 RC00010,RC00204 ko00000,ko00001,ko00002,ko01000,ko01002 - - - GATase,GMP_synt_C,NAD_synthase k59_504449_1 296591.Bpro_1713 2.14e-53 181.0 COG4091@1|root,COG4091@2|Bacteria,1MUZX@1224|Proteobacteria,2VI2Z@28216|Betaproteobacteria,4AAKE@80864|Comamonadaceae 28216|Betaproteobacteria E Oxidoreductase domain protein - - - - - - - - - - - - GFO_IDH_MocA,NAD_binding_3,SAF k59_1352534_1 688269.Theth_1889 1.02e-77 244.0 COG0205@1|root,COG0205@2|Bacteria,2GC8H@200918|Thermotogae 200918|Thermotogae F Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions pfp - 2.7.1.11,2.7.1.90 ko:K21071 ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130 - R00756,R00764,R02073,R03236,R04779 RC00002,RC00017 ko00000,ko00001,ko01000 - - - PFK k59_168403_1 864051.BurJ1DRAFT_1673 1.8e-08 53.1 COG2346@1|root,COG2346@2|Bacteria,1RH21@1224|Proteobacteria,2VSUJ@28216|Betaproteobacteria,1KM1R@119065|unclassified Burkholderiales 28216|Betaproteobacteria S Bacterial-like globin yjbI - - ko:K06886 - - - - ko00000 - - - Bac_globin k59_168403_2 1120968.AUBX01000015_gene3867 4.11e-26 104.0 28N6F@1|root,2ZBBB@2|Bacteria,4NGM1@976|Bacteroidetes,47P0U@768503|Cytophagia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_1466121_2 305700.B447_00800 6.26e-91 270.0 COG0740@1|root,COG0740@2|Bacteria,1MV46@1224|Proteobacteria,2VHAZ@28216|Betaproteobacteria,2KV8X@206389|Rhodocyclales 206389|Rhodocyclales O Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins clpP - 3.4.21.92 ko:K01358 ko04112,ko04212,map04112,map04212 - - - ko00000,ko00001,ko01000,ko01002 - - - CLP_protease k59_786847_1 436308.Nmar_1050 1.54e-70 216.0 COG1430@1|root,arCOG03116@2157|Archaea,41SP3@651137|Thaumarchaeota 651137|Thaumarchaeota S Uncharacterized ACR, COG1430 - - - ko:K09005 - - - - ko00000 - - - DUF192 k59_560347_1 857087.Metme_4526 4.76e-168 482.0 COG1838@1|root,COG1951@1|root,COG1838@2|Bacteria,COG1951@2|Bacteria,1MUV9@1224|Proteobacteria,1RN8U@1236|Gammaproteobacteria,1XDNP@135618|Methylococcales 135618|Methylococcales C Catalyzes the reversible hydration of fumarate to (S)- malate - - 4.2.1.2 ko:K01676 ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374 R01082 RC00443 ko00000,ko00001,ko00002,ko01000 - - - Fumerase,Fumerase_C k59_1637917_1 1229909.NSED_03625 3.04e-46 160.0 arCOG04054@1|root,arCOG04054@2157|Archaea,41SIQ@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_225658_1 243233.MCA2794 2.6e-61 199.0 COG0169@1|root,COG0169@2|Bacteria,1MVH4@1224|Proteobacteria,1RPB7@1236|Gammaproteobacteria,1XDS5@135618|Methylococcales 135618|Methylococcales E Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) aroE - 1.1.1.25 ko:K00014 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02413 RC00206 ko00000,ko00001,ko00002,ko01000 - - - Shikimate_DH,Shikimate_dh_N k59_1296515_1 1382304.JNIL01000001_gene972 3.29e-49 169.0 COG3173@1|root,COG3173@2|Bacteria,1TSCJ@1239|Firmicutes,4HB2X@91061|Bacilli 91061|Bacilli S Aminoglycoside phosphotransferase - - - - - - - - - - - - APH k59_562224_3 234267.Acid_4310 1.39e-34 147.0 COG0664@1|root,COG1142@1|root,COG1716@1|root,COG0664@2|Bacteria,COG1142@2|Bacteria,COG1716@2|Bacteria 2|Bacteria T histone H2A K63-linked ubiquitination - - 2.7.11.1,2.7.2.1 ko:K00925,ko:K08884,ko:K11894 ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200 M00357,M00579 R00315,R01353 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000,ko01001,ko02044 3.A.23.1 - - FHA,Fer4_7,Pkinase,Pyr_redox_2,Pyr_redox_3,Yop-YscD_cpl,cNMP_binding k59_1354239_2 287.DR97_3884 1.65e-132 387.0 COG1702@1|root,COG1702@2|Bacteria,1MVDV@1224|Proteobacteria,1RP2Y@1236|Gammaproteobacteria,1YEPK@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria T PhoH-like protein ybeZ GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - ko:K06217 - - - - ko00000 - - - PhoH k59_959223_1 113395.AXAI01000011_gene6450 4.63e-15 79.7 COG0683@1|root,COG0683@2|Bacteria,1MWR8@1224|Proteobacteria,2TS1S@28211|Alphaproteobacteria,3JTJR@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria E Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - - - - - - - - - - Peripla_BP_6 k59_562257_1 1519464.HY22_03790 1.29e-84 262.0 COG0151@1|root,COG0151@2|Bacteria 2|Bacteria F phosphoribosylamine-glycine ligase activity purD - 6.3.4.13,6.3.5.5 ko:K01945,ko:K01955 ko00230,ko00240,ko00250,ko01100,ko01110,ko01130,map00230,map00240,map00250,map01100,map01110,map01130 M00048,M00051 R00256,R00575,R01395,R04144,R10948,R10949 RC00002,RC00010,RC00043,RC00090,RC00166,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - - ATP-grasp_3,GARS_A,GARS_C,GARS_N k59_1129125_1 1380387.JADM01000011_gene3560 4.23e-51 174.0 COG0518@1|root,COG0519@1|root,COG0518@2|Bacteria,COG0519@2|Bacteria,1MU2A@1224|Proteobacteria,1RP81@1236|Gammaproteobacteria,1XHGT@135619|Oceanospirillales 135619|Oceanospirillales F Catalyzes the synthesis of GMP from XMP guaA - 6.3.5.2 ko:K01951 ko00230,ko00983,ko01100,map00230,map00983,map01100 M00050 R01230,R01231,R08244 RC00010,RC00204 ko00000,ko00001,ko00002,ko01000,ko01002 - - - GATase,GMP_synt_C,NAD_synthase k59_1129126_1 101162.XP_007683801.1 1.92e-23 101.0 COG3386@1|root,2QV6Y@2759|Eukaryota,39RN5@33154|Opisthokonta,3P0NU@4751|Fungi,3QTIY@4890|Ascomycota,207I1@147541|Dothideomycetes,4KGQS@92860|Pleosporales 4751|Fungi G SMP-30/Gluconolaconase/LRE-like region - - - - - - - - - - - - SGL k59_506285_1 1122137.AQXF01000004_gene1480 1.32e-25 106.0 COG1609@1|root,COG1609@2|Bacteria,1MVUR@1224|Proteobacteria,2U0SC@28211|Alphaproteobacteria 28211|Alphaproteobacteria K lacI family - - - ko:K02529 - - - - ko00000,ko03000 - - - LacI,Peripla_BP_3 k59_506285_2 1122137.AQXF01000003_gene1967 1.14e-61 211.0 COG1629@1|root,COG4774@1|root,COG1629@2|Bacteria,COG4774@2|Bacteria,1MWS3@1224|Proteobacteria,2TWDV@28211|Alphaproteobacteria 28211|Alphaproteobacteria P TonB-dependent receptor - - - - - - - - - - - - Plug,TonB_dep_Rec k59_506300_1 1110502.TMO_0855 7.25e-19 84.3 COG1878@1|root,COG1878@2|Bacteria,1MVWU@1224|Proteobacteria,2TUQ1@28211|Alphaproteobacteria,2JPSS@204441|Rhodospirillales 204441|Rhodospirillales S Putative cyclase - - - - - - - - - - - - Cyclase k59_959329_1 998674.ATTE01000001_gene2148 8.89e-65 202.0 COG1595@1|root,COG1595@2|Bacteria,1MX7T@1224|Proteobacteria,1RN64@1236|Gammaproteobacteria,460NZ@72273|Thiotrichales 72273|Thiotrichales K Belongs to the sigma-70 factor family. ECF subfamily - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 k59_959330_1 316407.85675991 1.25e-122 355.0 COG0517@1|root,COG0794@1|root,COG0517@2|Bacteria,COG0794@2|Bacteria,1MUXD@1224|Proteobacteria,1RMT9@1236|Gammaproteobacteria,3XMJQ@561|Escherichia 1236|Gammaproteobacteria M Involved in the biosynthesis of 3-deoxy-D-manno- octulosonate (KDO), a unique 8-carbon sugar component of lipopolysaccharides (LPSs) kdsD GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0005996,GO:0006082,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009987,GO:0016051,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0019146,GO:0019294,GO:0019752,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044281,GO:0044283,GO:0046364,GO:0046394,GO:0046400,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 5.3.1.13 ko:K06041 ko00540,ko01100,map00540,map01100 M00063 R01530 RC00541 ko00000,ko00001,ko00002,ko01000,ko01005 - - iECH74115_1262.ECH74115_4519,iECSP_1301.ECSP_4172,iECs_1301.ECs4076,iPC815.YPO3577,iSFV_1184.SFV_3227,iSFxv_1172.SFxv_3550,iYL1228.KPN_03607,iZ_1308.Z4560 CBS,SIS k59_959355_1 1121875.KB907547_gene2887 1.42e-12 73.9 COG1073@1|root,COG1073@2|Bacteria,4NG6A@976|Bacteroidetes,1I062@117743|Flavobacteriia 976|Bacteroidetes S alpha beta - - - - - - - - - - - - - k59_562391_1 383372.Rcas_2077 2.18e-106 342.0 COG0366@1|root,COG0366@2|Bacteria,2G7SV@200795|Chloroflexi 200795|Chloroflexi G Alpha amylase, catalytic domain - - - - - - - - - - - - Alpha-amylase k59_1354350_1 1227488.C477_23070 3.35e-47 165.0 COG0022@1|root,arCOG01052@2157|Archaea,2XTBG@28890|Euryarchaeota,23SY2@183963|Halobacteria 183963|Halobacteria C COG0022 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit - - - ko:K21417 - - - - ko00000,ko01000 - - - Transket_pyr,Transketolase_C k59_451128_1 1244869.H261_10184 6.54e-36 128.0 COG0394@1|root,COG0394@2|Bacteria,1RH90@1224|Proteobacteria,2U72X@28211|Alphaproteobacteria,2JSNX@204441|Rhodospirillales 204441|Rhodospirillales T Belongs to the low molecular weight phosphotyrosine protein phosphatase family - - 3.1.3.48 ko:K01104 - - - - ko00000,ko01000 - - - LMWPc k59_1298391_1 926569.ANT_13770 6.54e-77 246.0 COG0056@1|root,COG0056@2|Bacteria,2G5YQ@200795|Chloroflexi 200795|Chloroflexi F Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit atpA - 3.6.3.14 ko:K02111 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - - ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N k59_1804535_1 4932.Q0065 1.13e-113 340.0 COG0843@1|root,KOG4769@2759|Eukaryota,38JQ7@33154|Opisthokonta,3NYGG@4751|Fungi,3QSKE@4890|Ascomycota,3RU36@4891|Saccharomycetes 33154|Opisthokonta C Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B cox1 GO:0003674,GO:0003824,GO:0004129,GO:0004518,GO:0004519,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0005746,GO:0005751,GO:0006091,GO:0006119,GO:0006123,GO:0006139,GO:0006163,GO:0006259,GO:0006310,GO:0006314,GO:0006316,GO:0006396,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0008380,GO:0009055,GO:0009060,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0010467,GO:0015002,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015672,GO:0015980,GO:0015988,GO:0015990,GO:0016020,GO:0016021,GO:0016070,GO:0016310,GO:0016491,GO:0016675,GO:0016676,GO:0016787,GO:0016788,GO:0017144,GO:0019637,GO:0019646,GO:0019693,GO:0019866,GO:0022857,GO:0022890,GO:0022900,GO:0022904,GO:0031090,GO:0031224,GO:0031966,GO:0031967,GO:0031975,GO:0032991,GO:0034220,GO:0034641,GO:0042773,GO:0042775,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044260,GO:0044281,GO:0044422,GO:0044424,GO:0044425,GO:0044429,GO:0044444,GO:0044446,GO:0044455,GO:0044464,GO:0045277,GO:0045333,GO:0046034,GO:0046483,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0055114,GO:0070069,GO:0070469,GO:0071704,GO:0072521,GO:0090304,GO:0090305,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098798,GO:0098800,GO:0098803,GO:1901135,GO:1901360,GO:1901564,GO:1902600 1.9.3.1 ko:K02256 ko00190,ko01100,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map04260,map04714,map04932,map05010,map05012,map05016 M00154 - - ko00000,ko00001,ko00002,ko01000,ko03029 3.D.4.11,3.D.4.7,3.D.4.8 - - COX1,LAGLIDADG_1 k59_506353_1 926550.CLDAP_06860 4.01e-55 179.0 COG0194@1|root,COG0194@2|Bacteria,2G6EW@200795|Chloroflexi 200795|Chloroflexi F Essential for recycling GMP and indirectly, cGMP gmk - 2.7.4.8 ko:K00942 ko00230,ko01100,map00230,map01100 M00050 R00332,R02090 RC00002 ko00000,ko00001,ko00002,ko01000 - - - Guanylate_kin k59_1298404_2 530564.Psta_2657 3.62e-95 309.0 COG1305@1|root,COG4196@1|root,COG1305@2|Bacteria,COG4196@2|Bacteria,2IY13@203682|Planctomycetes 203682|Planctomycetes E Putative amidoligase enzyme (DUF2126) - - - - - - - - - - - - Bact_transglu_N,DUF2126,Transglut_core k59_451146_1 1123393.KB891316_gene1904 4.05e-47 166.0 COG1220@1|root,COG1220@2|Bacteria,1MVK9@1224|Proteobacteria,2VHG3@28216|Betaproteobacteria,1KSND@119069|Hydrogenophilales 119069|Hydrogenophilales O this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis hslU - - ko:K03667 - - - - ko00000,ko03110 - - - AAA_2,ClpB_D2-small k59_959398_1 1121396.KB893120_gene3067 3.74e-123 361.0 COG2801@1|root,COG2801@2|Bacteria,1P5SB@1224|Proteobacteria,42YNG@68525|delta/epsilon subdivisions,2WU6B@28221|Deltaproteobacteria,2MN61@213118|Desulfobacterales 28221|Deltaproteobacteria L Integrase - - - - - - - - - - - - - k59_1804552_1 1122137.AQXF01000003_gene2162 3.88e-108 323.0 COG0823@1|root,COG0823@2|Bacteria,1MV09@1224|Proteobacteria,2TR03@28211|Alphaproteobacteria 28211|Alphaproteobacteria U Involved in the TonB-independent uptake of proteins tolB - - ko:K03641 - - - - ko00000,ko02000 2.C.1.2 - - PD40,TolB_N k59_1354371_2 706439.HMPREF9057_00236 1.94e-17 94.4 COG0515@1|root,COG2815@1|root,COG0515@2|Bacteria,COG2815@2|Bacteria,2GJ1J@201174|Actinobacteria,4D3IX@85005|Actinomycetales 201174|Actinobacteria KLT serine threonine protein kinase pknL GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018107,GO:0018193,GO:0018210,GO:0019216,GO:0019217,GO:0019222,GO:0019538,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0036211,GO:0042304,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046777,GO:0046890,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051055,GO:0062012,GO:0062014,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0140096,GO:1901564 2.7.11.1 ko:K08884,ko:K12132 - - - - ko00000,ko01000,ko01001 - - - PASTA,Pkinase k59_1354371_3 1121405.dsmv_1283 1.04e-37 135.0 COG4385@1|root,COG4385@2|Bacteria,1N0CW@1224|Proteobacteria,42UPU@68525|delta/epsilon subdivisions,2WR0W@28221|Deltaproteobacteria,2MNND@213118|Desulfobacterales 28221|Deltaproteobacteria S Phage tail protein (Tail_P2_I) - - - - - - - - - - - - Tail_P2_I k59_451158_1 326424.FRAAL5275 9.54e-107 324.0 COG2124@1|root,COG2124@2|Bacteria,2GKCG@201174|Actinobacteria 201174|Actinobacteria Q cytochrome P450 cyp - 1.14.15.14 ko:K20497 - - - - ko00000,ko00199,ko01000 - - - p450 k59_959425_1 1415778.JQMM01000001_gene1314 1.43e-102 310.0 COG0305@1|root,COG0305@2|Bacteria,1MUG9@1224|Proteobacteria,1RPM2@1236|Gammaproteobacteria,1J4Z9@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins dnaB GO:0003674,GO:0003678,GO:0003824,GO:0004386,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006268,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009628,GO:0009987,GO:0010212,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0032392,GO:0032508,GO:0034641,GO:0034645,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051276,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360,GO:1901576 3.6.4.12 ko:K02314 ko03030,ko04112,map03030,map04112 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB,DnaB_C k59_451167_1 314230.DSM3645_29956 6.69e-25 109.0 COG0515@1|root,COG0515@2|Bacteria,2IY73@203682|Planctomycetes 203682|Planctomycetes KLT PFAM Protein kinase domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase,TPR_16 k59_1804600_1 1229909.NSED_01015 6.94e-113 328.0 COG1573@1|root,arCOG00905@2157|Archaea 2157|Archaea L Uracil-DNA glycosylase - GO:0003674,GO:0003824,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097506,GO:0140097,GO:1901360 3.2.2.27 ko:K21929 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - UDG k59_1354398_1 1203190.CAJP01000024_gene241 1.41e-21 99.0 COG4558@1|root,COG4558@2|Bacteria,2GNZB@201174|Actinobacteria,22KSN@1653|Corynebacteriaceae 201174|Actinobacteria P Periplasmic binding protein hmuT - - ko:K02016 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko02000 3.A.1.14 - - Peripla_BP_2 k59_562519_2 1423747.BAMJ01000039_gene1989 3.46e-13 67.8 COG0634@1|root,COG0634@2|Bacteria,1V1C9@1239|Firmicutes,4HFZ2@91061|Bacilli,3F56C@33958|Lactobacillaceae 91061|Bacilli F Belongs to the purine pyrimidine phosphoribosyltransferase family hpt - 2.4.2.8 ko:K00760 ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 - R00190,R01132,R01229,R02142,R08237,R08238,R08245 RC00063,RC00122 ko00000,ko00001,ko01000 - - - Pribosyltran k59_788702_1 1229909.NSED_09005 2.28e-187 534.0 COG1155@1|root,arCOG00868@2157|Archaea,41SZU@651137|Thaumarchaeota 651137|Thaumarchaeota F Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit atpA - 3.6.3.14,3.6.3.15 ko:K02117 ko00190,ko01100,map00190,map01100 M00159 - - ko00000,ko00001,ko00002,ko01000 3.A.2.2,3.A.2.3 - - ATP-synt_ab,ATP-synt_ab_N,ATP-synt_ab_Xtn k59_1804636_1 290397.Adeh_3200 2.22e-30 127.0 COG3303@1|root,COG3303@2|Bacteria,1NT38@1224|Proteobacteria,43CCP@68525|delta/epsilon subdivisions,2X7NK@28221|Deltaproteobacteria,2YZY2@29|Myxococcales 28221|Deltaproteobacteria C Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process - - - - - - - - - - - - - k59_1354429_1 948106.AWZT01000006_gene3243 4.52e-90 275.0 COG0150@1|root,COG0150@2|Bacteria,1MURG@1224|Proteobacteria,2VHJT@28216|Betaproteobacteria,1K2VU@119060|Burkholderiaceae 28216|Betaproteobacteria F Phosphoribosylformylglycinamidine cyclo-ligase purM - 6.3.3.1 ko:K01933 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04208 RC01100 ko00000,ko00001,ko00002,ko01000 - - - AIRS,AIRS_C k59_506491_1 436308.Nmar_1229 1.86e-55 172.0 arCOG08720@1|root,arCOG08720@2157|Archaea,41STI@651137|Thaumarchaeota 651137|Thaumarchaeota S Domain of unknown function (DUF2024) - - - - - - - - - - - - DUF2024 k59_506491_2 436308.Nmar_1230 7.12e-29 103.0 arCOG08719@1|root,arCOG08719@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_506491_3 1229909.NSED_06905 2.08e-22 95.5 COG3808@1|root,arCOG04949@2157|Archaea,41SZG@651137|Thaumarchaeota 651137|Thaumarchaeota C Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force hppA - 3.6.1.1 ko:K15987 ko00190,map00190 - - - ko00000,ko00001,ko01000 3.A.10.1 - - H_PPase k59_1354459_2 1229909.NSED_05130 1.11e-25 102.0 COG0159@1|root,arCOG01086@2157|Archaea,41SG0@651137|Thaumarchaeota 651137|Thaumarchaeota E The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate trpA - 4.2.1.20 ko:K01695 ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230 M00023 R00674,R02340,R02722 RC00209,RC00210,RC00700,RC00701,RC02868 ko00000,ko00001,ko00002,ko01000 - - - Trp_syntA k59_1804667_1 504487.JCM19302_1777 2.69e-92 288.0 COG1132@1|root,COG1132@2|Bacteria,4NEAG@976|Bacteroidetes,1HY1E@117743|Flavobacteriia 976|Bacteroidetes V ABC transporter - - - ko:K18890 ko02010,map02010 M00707 - - ko00000,ko00001,ko00002,ko02000 3.A.1.106.13,3.A.1.106.5 - - ABC_membrane,ABC_tran k59_451251_2 1229909.NSED_06400 2.77e-15 76.6 COG3794@1|root,arCOG08764@1|root,arCOG02926@2157|Archaea,arCOG08764@2157|Archaea 2157|Archaea C PFAM blue (type 1) copper domain protein - - - - - - - - - - - - Copper-bind k59_562590_1 1041522.MCOL_V220276 3.37e-35 135.0 COG2159@1|root,COG2159@2|Bacteria,2HG7W@201174|Actinobacteria,237SC@1762|Mycobacteriaceae 201174|Actinobacteria S amidohydrolase - - - - - - - - - - - - Amidohydro_2 k59_677453_1 323261.Noc_2988 7.7e-76 244.0 COG0741@1|root,COG1388@1|root,COG0741@2|Bacteria,COG1388@2|Bacteria,1MWKE@1224|Proteobacteria,1RMFZ@1236|Gammaproteobacteria,1X28I@135613|Chromatiales 135613|Chromatiales M Lysin motif - - - ko:K08307 - - - - ko00000,ko01000,ko01011 - - - LysM,SLT k59_1298576_1 400682.PAC_15709637 1.48e-103 324.0 COG0060@1|root,KOG0434@2759|Eukaryota,38CIS@33154|Opisthokonta,3BA51@33208|Metazoa 33208|Metazoa J isoleucyl-tRNA aminoacylation Aats-ile GO:0003674,GO:0003824,GO:0004812,GO:0004822,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006428,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017101,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.5 ko:K01870 ko00970,map00970 M00359,M00360 R03656 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,RRM_1,tRNA-synt_1 k59_959605_1 394221.Mmar10_0506 4.72e-64 207.0 COG0845@1|root,COG0845@2|Bacteria,1R3U4@1224|Proteobacteria,2TW9A@28211|Alphaproteobacteria,43ZQD@69657|Hyphomonadaceae 28211|Alphaproteobacteria M Biotin-lipoyl like MA20_09450 - - ko:K01993 - - - - ko00000 - - - Biotin_lipoyl_2,HlyD_3 k59_959605_2 414684.RC1_2057 1.1e-29 114.0 COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,2TR2P@28211|Alphaproteobacteria,2JYV7@204441|Rhodospirillales 204441|Rhodospirillales V AAA domain, putative AbiEii toxin, Type IV TA system - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_506554_1 1218076.BAYB01000009_gene2063 5.49e-268 776.0 COG0439@1|root,COG4799@1|root,COG0439@2|Bacteria,COG4799@2|Bacteria,1MU4H@1224|Proteobacteria,2VJRB@28216|Betaproteobacteria,1K5FF@119060|Burkholderiaceae 28216|Betaproteobacteria I Biotin carboxylase C-terminal domain - - - - - - - - - - - - Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2,Carboxyl_trans k59_677472_1 1131269.AQVV01000115_gene2303 9.58e-20 90.5 COG1538@1|root,COG1538@2|Bacteria 2|Bacteria MU efflux transmembrane transporter activity - - - ko:K12340 ko01501,ko01503,ko02020,ko03070,ko04626,ko05133,map01501,map01503,map02020,map03070,map04626,map05133 M00325,M00326,M00339,M00571,M00575,M00646,M00647,M00696,M00697,M00709,M00720,M00821 - - ko00000,ko00001,ko00002,ko01504,ko02000,ko02044 1.B.17,2.A.6.2 - - OEP k59_1468340_1 1122962.AULH01000009_gene3840 5.42e-78 251.0 28HPK@1|root,2Z7XJ@2|Bacteria,1NBHR@1224|Proteobacteria,2TT3N@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Bacteriophage head to tail connecting protein - - - - - - - - - - - - Head-tail_con k59_1129389_1 83406.HDN1F_05920 3.98e-36 142.0 COG1596@1|root,COG1596@2|Bacteria,1N7GP@1224|Proteobacteria,1RQSM@1236|Gammaproteobacteria 1236|Gammaproteobacteria M polysaccharide export - - - ko:K01991 ko02026,map02026 - - - ko00000,ko00001,ko02000 1.B.18 - - Poly_export,SLBB k59_1468354_1 1121921.KB898707_gene1203 9.3e-90 288.0 COG0567@1|root,COG0567@2|Bacteria,1MVBF@1224|Proteobacteria,1RN8K@1236|Gammaproteobacteria,2PMKW@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria C 2-oxoglutarate dehydrogenase N-terminus sucA GO:0003674,GO:0003824,GO:0004591,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016491,GO:0016624,GO:0016903,GO:0016999,GO:0017144,GO:0019752,GO:0032991,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045239,GO:0045240,GO:0045252,GO:0045333,GO:0055114,GO:0071704,GO:0072350,GO:1902494,GO:1990204,GO:1990234 1.2.4.2 ko:K00164 ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00032 R00621,R01933,R01940,R03316,R08549 RC00004,RC00027,RC00627,RC02743,RC02833,RC02883 br01601,ko00000,ko00001,ko00002,ko01000 - - - 2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr k59_1804734_1 717231.Flexsi_0128 3.33e-55 189.0 COG1207@1|root,COG1207@2|Bacteria,2GF2B@200930|Deferribacteres 200930|Deferribacteres M Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain glmU - 2.3.1.157,2.7.7.23 ko:K04042 ko00520,ko01100,ko01130,map00520,map01100,map01130 M00362 R00416,R05332 RC00002,RC00004,RC00166 ko00000,ko00001,ko00002,ko01000 - - - Hexapep,NTP_transf_3,NTP_transferase k59_506590_2 436308.Nmar_0564 6.14e-61 191.0 COG1607@1|root,arCOG00773@2157|Archaea 436308.Nmar_0564|- I Acyl-CoA hydrolase - - 4.3.1.14 ko:K18014 ko00310,map00310 - R03030 RC00833 ko00000,ko00001,ko01000 - - - - k59_788812_1 580332.Slit_2644 9.03e-43 159.0 COG4262@1|root,COG4262@2|Bacteria,1RFPU@1224|Proteobacteria,2VQJ5@28216|Betaproteobacteria 28216|Betaproteobacteria E Spermidine synthase - - 2.5.1.16 ko:K00797 ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100 M00034,M00133 R01920,R02869,R08359 RC00021,RC00053 ko00000,ko00001,ko00002,ko01000 - - - Spermine_synth k59_562687_1 1288494.EBAPG3_17970 3.46e-84 263.0 COG1530@1|root,COG1530@2|Bacteria,1MV65@1224|Proteobacteria,2VI3N@28216|Betaproteobacteria,372DK@32003|Nitrosomonadales 28216|Betaproteobacteria J Ribonuclease E/G family cafA - - ko:K08301 - - - - ko00000,ko01000,ko03009,ko03019 - - - RNase_E_G,S1 k59_1298645_1 33898.JRHJ01000055_gene5777 3.8e-09 62.8 COG0823@1|root,COG1228@1|root,COG0823@2|Bacteria,COG1228@2|Bacteria,2GMNT@201174|Actinobacteria 201174|Actinobacteria U Periplasmic component of the Tol biopolymer transport system - - - - - - - - - - - - Amidohydro_1,Amidohydro_3,PD40,TAT_signal k59_1298651_1 436308.Nmar_0685 6.92e-71 220.0 COG0561@1|root,arCOG01213@2157|Archaea,41SIV@651137|Thaumarchaeota 651137|Thaumarchaeota S Phosphoglycolate phosphatase - - 3.1.3.18 ko:K22223 ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130 - R01334 RC00017 ko00000,ko00001,ko01000 - - - Hydrolase_3 k59_1298651_2 436308.Nmar_0686 3.68e-16 77.4 COG0018@1|root,arCOG00487@2157|Archaea,41SAI@651137|Thaumarchaeota 651137|Thaumarchaeota J Belongs to the class-I aminoacyl-tRNA synthetase family argS - 6.1.1.19 ko:K01887 ko00970,map00970 M00359,M00360 R03646 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d k59_571497_8 437329.A5A3P4_9CAUD 2.77e-41 162.0 4QB49@10239|Viruses,4QUZD@35237|dsDNA viruses no RNA stage,4QPU2@28883|Caudovirales,4QKRQ@10699|Siphoviridae 10699|Siphoviridae S Domain of unknown function (DUF4055) - - - - - - - - - - - - - k59_571497_14 215803.DB30_1227 2.04e-09 63.2 COG2131@1|root,COG2131@2|Bacteria,1QK9X@1224|Proteobacteria,4309D@68525|delta/epsilon subdivisions,2WV7M@28221|Deltaproteobacteria,2YVHW@29|Myxococcales 28221|Deltaproteobacteria F MafB19-like deaminase - - - - - - - - - - - - dCMP_cyt_deam_1 k59_571497_16 596153.Alide_1651 1.26e-12 64.7 2FCTD@1|root,344WB@2|Bacteria,1P1TF@1224|Proteobacteria,2W4FZ@28216|Betaproteobacteria,4AIAY@80864|Comamonadaceae 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_741456_2 1196835.A458_15650 2.27e-09 58.5 COG4967@1|root,COG4967@2|Bacteria,1QDFP@1224|Proteobacteria,1T9EF@1236|Gammaproteobacteria,1Z2UT@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria NU type IV pilus modification protein PilV - - - ko:K10927 ko05111,map05111 - - - ko00000,ko00001,ko02044 - - - N_methyl k59_1362856_1 938709.AUSH02000017_gene1059 8.8e-105 316.0 COG1012@1|root,COG1012@2|Bacteria,4NFPJ@976|Bacteroidetes 976|Bacteroidetes C Belongs to the aldehyde dehydrogenase family pcd - 1.2.1.3 ko:K00128 ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130 M00135 R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146 RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_1136675_1 1242864.D187_005919 5.61e-33 118.0 COG0346@1|root,COG0346@2|Bacteria,1RA9H@1224|Proteobacteria,439N8@68525|delta/epsilon subdivisions,2X4ZH@28221|Deltaproteobacteria,2YZW4@29|Myxococcales 28221|Deltaproteobacteria E Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - 4.4.1.5 ko:K01759 ko00620,map00620 - R02530 RC00004,RC00740 ko00000,ko00001,ko01000 - - - Glyoxalase_4 k59_1136675_2 1121865.OMW_01492 2.93e-39 146.0 COG0249@1|root,COG0249@2|Bacteria,1TPRJ@1239|Firmicutes,4HA63@91061|Bacilli,4B01X@81852|Enterococcaceae 91061|Bacilli L that it carries out the mismatch recognition step. This protein has a weak ATPase activity mutS GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - ko:K03555 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V k59_798288_1 436308.Nmar_0229 3.05e-99 304.0 COG0532@1|root,arCOG01560@2157|Archaea,41SBY@651137|Thaumarchaeota 651137|Thaumarchaeota J Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2 infB - - ko:K03243 ko03013,map03013 - - - ko00000,ko00001,ko03012 - - - GTP_EFTU,GTP_EFTU_D4,IF-2 k59_798288_2 1229909.NSED_00965 9.16e-63 193.0 COG0105@1|root,arCOG04313@2157|Archaea,41SN1@651137|Thaumarchaeota 651137|Thaumarchaeota F Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate ndk - 2.7.4.6 ko:K00940 ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016 M00049,M00050,M00052,M00053 R00124,R00139,R00156,R00330,R00570,R00722,R01137,R01857,R02093,R02326,R02331,R03530,R11894,R11895 RC00002 ko00000,ko00001,ko00002,ko01000,ko04131 - - - NDK k59_1306653_1 1088721.NSU_1374 3.16e-62 211.0 COG4232@1|root,COG4233@1|root,COG4232@2|Bacteria,COG4233@2|Bacteria,1MU8W@1224|Proteobacteria,2TTUM@28211|Alphaproteobacteria,2K11D@204457|Sphingomonadales 204457|Sphingomonadales CO Thiol disulfide interchange protein - - - - - - - - - - - - DsbC,DsbD,Thioredoxin_7 k59_798289_1 640081.Dsui_3059 5.11e-150 438.0 COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,2VHEV@28216|Betaproteobacteria,2KU76@206389|Rhodocyclales 206389|Rhodocyclales O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins ftsH - - ko:K03798 - M00742 - - ko00000,ko00002,ko01000,ko01002,ko03110 - - - AAA,FtsH_ext,Peptidase_M41 k59_571522_1 1207063.P24_16425 4.51e-28 127.0 COG2911@1|root,COG4733@1|root,COG4932@1|root,COG2911@2|Bacteria,COG4733@2|Bacteria,COG4932@2|Bacteria,1P8N9@1224|Proteobacteria,2TXN3@28211|Alphaproteobacteria,2JZ5T@204441|Rhodospirillales 204441|Rhodospirillales U Domain of unknown function (DUF4347) - - - ko:K20276 ko02024,map02024 - - - ko00000,ko00001 - - - DUF4347 k59_741482_1 283942.IL2401 8.47e-39 138.0 29EG8@1|root,334DW@2|Bacteria,1NFZA@1224|Proteobacteria,1SCN3@1236|Gammaproteobacteria,2QGT7@267893|Idiomarinaceae 1236|Gammaproteobacteria S Capsule biosynthesis CapC capC - - ko:K22116 - - - - ko00000 - - - Caps_synth_CapC k59_741482_2 740709.A10D4_05217 8.27e-66 214.0 COG0769@1|root,COG0769@2|Bacteria,1QYFB@1224|Proteobacteria,1T3Q5@1236|Gammaproteobacteria,2QGQ5@267893|Idiomarinaceae 1236|Gammaproteobacteria M Mur ligase middle domain - - - ko:K01932 - - - - ko00000,ko01000 - - - Mur_ligase_M k59_1419053_2 502025.Hoch_1338 1.88e-12 66.6 2FGT4@1|root,348NF@2|Bacteria,1QAAV@1224|Proteobacteria,434Y1@68525|delta/epsilon subdivisions,2WZ8V@28221|Deltaproteobacteria,2Z1KQ@29|Myxococcales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_514858_1 398578.Daci_3143 2.06e-77 242.0 COG3485@1|root,COG3485@2|Bacteria,1MV6K@1224|Proteobacteria,2VRQW@28216|Betaproteobacteria,4AFYX@80864|Comamonadaceae 28216|Betaproteobacteria Q Intradiol ring-cleavage dioxygenase - - - - - - - - - - - - Dioxygenase_C k59_854731_2 1163389.OOM_1208 0.000208 45.4 COG2271@1|root,COG2271@2|Bacteria,1MX4V@1224|Proteobacteria,1RMB3@1236|Gammaproteobacteria 1236|Gammaproteobacteria G transporter glpT - - ko:K02445,ko:K07784 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.1.4.1,2.A.1.4.3 - - MFS_1 k59_967075_1 1122599.AUGR01000019_gene3080 4.04e-80 260.0 COG3497@1|root,COG3497@2|Bacteria,1MX89@1224|Proteobacteria,1RQUU@1236|Gammaproteobacteria,1XPPF@135619|Oceanospirillales 135619|Oceanospirillales S Phage tail sheath C-terminal domain - - - - - - - - - - - - Phage_sheath_1C k59_63997_2 2074.JNYD01000003_gene3902 4.07e-06 48.1 COG0604@1|root,COG0604@2|Bacteria,2GKHW@201174|Actinobacteria,4E9SY@85010|Pseudonocardiales 201174|Actinobacteria C Zinc-binding dehydrogenase qor - 1.6.5.5 ko:K00344 - - - - ko00000,ko01000 - - - ADH_N,ADH_zinc_N k59_7243_1 1459636.NTE_01510 1.54e-20 95.1 arCOG02362@1|root,arCOG02362@2157|Archaea 1459636.NTE_01510|- - - - - - - - - - - - - - - - k59_1362883_1 504487.JCM19302_4001 4.42e-82 253.0 COG1253@1|root,COG1253@2|Bacteria,4NE7C@976|Bacteroidetes,1HYD7@117743|Flavobacteriia 976|Bacteroidetes S COGs COG1253 Hemolysins and related protein containing CBS domains - - - - - - - - - - - - CBS,DUF21 k59_1701543_1 1347342.BN863_2530 3.05e-83 260.0 COG1538@1|root,COG1538@2|Bacteria,4NEEN@976|Bacteroidetes,1HWPI@117743|Flavobacteriia 976|Bacteroidetes MU Outer membrane efflux protein - - - ko:K12340 ko01501,ko01503,ko02020,ko03070,ko04626,ko05133,map01501,map01503,map02020,map03070,map04626,map05133 M00325,M00326,M00339,M00571,M00575,M00646,M00647,M00696,M00697,M00709,M00720,M00821 - - ko00000,ko00001,ko00002,ko01504,ko02000,ko02044 1.B.17,2.A.6.2 - - OEP k59_798324_1 1244869.H261_13838 1.3e-43 167.0 COG0515@1|root,COG2203@1|root,COG3899@1|root,COG0515@2|Bacteria,COG2203@2|Bacteria,COG3899@2|Bacteria,1RGKE@1224|Proteobacteria,2TWRS@28211|Alphaproteobacteria,2JW21@204441|Rhodospirillales 28211|Alphaproteobacteria KLT COG0515 Serine threonine protein kinase - - - - - - - - - - - - AAA_16,GAF,Pkinase k59_1306681_1 452637.Oter_3293 2.55e-94 293.0 COG0281@1|root,COG0281@2|Bacteria,46UI4@74201|Verrucomicrobia,3K7KY@414999|Opitutae 414999|Opitutae C Malic enzyme, NAD binding domain - - 1.1.1.40 ko:K00029 ko00620,ko00710,ko01100,ko01120,ko01200,map00620,map00710,map01100,map01120,map01200 M00169,M00172 R00216 RC00105 ko00000,ko00001,ko00002,ko01000 - - - Malic_M,malic k59_1080143_1 1122135.KB893157_gene394 6.73e-83 265.0 COG1884@1|root,COG1884@2|Bacteria,1MUXX@1224|Proteobacteria,2TQYC@28211|Alphaproteobacteria 28211|Alphaproteobacteria I Methylmalonyl-CoA mutase bhbA - 5.4.99.2 ko:K01847 ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200 M00373,M00376,M00741 R00833 RC00395 ko00000,ko00001,ko00002,ko01000 - - - B12-binding,MM_CoA_mutase k59_346436_1 118161.KB235922_gene942 4.25e-21 90.9 COG0840@1|root,COG0840@2|Bacteria,1G3V5@1117|Cyanobacteria,3VJ1H@52604|Pleurocapsales 1117|Cyanobacteria NT Protein of unknown function (DUF3365) - - - - - - - - - - - - DUF3365 k59_346436_2 246197.MXAN_1246 4.57e-20 86.3 COG1051@1|root,COG1051@2|Bacteria,1NA5A@1224|Proteobacteria,433DA@68525|delta/epsilon subdivisions,2WYEC@28221|Deltaproteobacteria 28221|Deltaproteobacteria F NUDIX domain - - - - - - - - - - - - NUDIX k59_1136698_1 1219035.NT2_03_00360 5.03e-05 43.9 COG1959@1|root,COG1959@2|Bacteria,1N05H@1224|Proteobacteria,2UBZM@28211|Alphaproteobacteria,2K545@204457|Sphingomonadales 204457|Sphingomonadales K Transcriptional regulator - - - ko:K13771 ko05132,map05132 - - - ko00000,ko00001,ko03000 - - - Rrf2 k59_1136698_2 448385.sce5085 1.08e-45 153.0 COG1017@1|root,COG1017@2|Bacteria 2|Bacteria C nitric oxide dioxygenase activity VPA1107 - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - Globin k59_1306703_1 1088721.NSU_1063 1.57e-37 138.0 COG0654@1|root,COG0654@2|Bacteria,1N8DE@1224|Proteobacteria,2TU88@28211|Alphaproteobacteria,2K0B6@204457|Sphingomonadales 204457|Sphingomonadales CH Lycopene cyclase protein - - 5.5.1.19 ko:K06443 ko00906,ko01100,ko01110,map00906,map01100,map01110 M00097 R03824,R04801,R05341,R06962,R07856 RC01004,RC01964 ko00000,ko00001,ko00002,ko01000 - - - Lycopene_cycl k59_1306703_2 555793.WSK_3202 1.03e-13 68.9 COG1247@1|root,COG1247@2|Bacteria,1RDHN@1224|Proteobacteria,2U98I@28211|Alphaproteobacteria,2K490@204457|Sphingomonadales 204457|Sphingomonadales M Acetyltransferase (GNAT) domain - - 2.3.1.183 ko:K03823 ko00440,ko01130,map00440,map01130 - R08871,R08938 RC00004,RC00064 ko00000,ko00001,ko01000 - - - Acetyltransf_4 k59_346452_1 550540.Fbal_0782 6.36e-08 56.2 COG0196@1|root,COG0196@2|Bacteria,1MV9I@1224|Proteobacteria,1RN44@1236|Gammaproteobacteria 1236|Gammaproteobacteria H Belongs to the ribF family ribF GO:0003674,GO:0003824,GO:0003919,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008531,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016779,GO:0044237,GO:0070566 2.7.1.26,2.7.7.2 ko:K11753 ko00740,ko01100,ko01110,map00740,map01100,map01110 M00125 R00161,R00549 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - iETEC_1333.ETEC_0025,iJN746.PP_0602 FAD_syn,Flavokinase k59_910969_1 1280949.HAD_10460 4.23e-32 125.0 COG1629@1|root,COG4771@2|Bacteria,1MUWN@1224|Proteobacteria,2TUIR@28211|Alphaproteobacteria,43WUE@69657|Hyphomonadaceae 28211|Alphaproteobacteria P COG1629 Outer membrane receptor proteins, mostly Fe transport - - - - - - - - - - - - Plug,TonB_dep_Rec k59_910969_2 1280949.HAD_10465 3.04e-85 270.0 COG2365@1|root,COG2365@2|Bacteria,1R4XF@1224|Proteobacteria,2U0KA@28211|Alphaproteobacteria 28211|Alphaproteobacteria T Protein tyrosine serine phosphatase - - 3.1.3.48 ko:K01104 - - - - ko00000,ko01000 - - - Y_phosphatase3 k59_402327_1 391626.OAN307_c03800 2.29e-103 310.0 COG2826@1|root,COG2826@2|Bacteria,1PP49@1224|Proteobacteria,2TRVA@28211|Alphaproteobacteria 28211|Alphaproteobacteria L COG2826 Transposase and inactivated derivatives, IS30 family - - - - - - - - - - - - HTH_38,rve k59_684658_1 1380355.JNIJ01000007_gene3260 4.19e-05 45.4 COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TR8X@28211|Alphaproteobacteria,3JT51@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria T Histidine kinase-like ATPases - - - - - - - - - - - - ABC_sub_bind,HATPase_c,HisKA k59_684658_2 768671.ThimaDRAFT_0848 1.47e-50 166.0 COG4566@1|root,COG4566@2|Bacteria,1N6WR@1224|Proteobacteria,1S0TV@1236|Gammaproteobacteria 1236|Gammaproteobacteria K response regulator - - - - - - - - - - - - GerE,Response_reg,Trans_reg_C k59_910971_1 566466.NOR53_1763 4.91e-86 259.0 COG3384@1|root,COG3384@2|Bacteria,1MW77@1224|Proteobacteria,1RQIK@1236|Gammaproteobacteria,1J72C@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Catalytic LigB subunit of aromatic ring-opening dioxygenase ligB_1 - 1.13.11.8 ko:K04101 ko00362,ko00624,ko00627,ko01120,map00362,map00624,map00627,map01120 - R01632,R03550,R04280,R09565 RC00233,RC00387,RC00535,RC02567,RC02694 br01602,ko00000,ko00001,ko01000 - - - LigB k59_910971_2 566466.NOR53_768 4.53e-68 208.0 COG3384@1|root,COG3384@2|Bacteria,1RA8A@1224|Proteobacteria,1S8CE@1236|Gammaproteobacteria,1JAUT@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Aromatic-ring-opening dioxygenase LigAB, LigA subunit ligA_1 - 1.13.11.8 ko:K04100 ko00362,ko00624,ko00627,ko01120,map00362,map00624,map00627,map01120 - R01632,R03550,R04280,R09565 RC00233,RC00387,RC00535,RC02567,RC02694 br01602,ko00000,ko00001,ko01000 - - - LigA k59_910971_3 566466.NOR53_1336 4.12e-194 540.0 COG3618@1|root,COG3618@2|Bacteria,1N2QM@1224|Proteobacteria,1RQ8V@1236|Gammaproteobacteria,1J5VK@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S metal-dependent hydrolase of the TIM-barrel fold - - 3.1.1.57 ko:K10221 ko00362,ko00627,ko01120,map00362,map00627,map01120 - R04277 RC03110 ko00000,ko00001,ko01000 - - - Amidohydro_2 k59_910971_4 316273.XCV4255 3.05e-42 147.0 COG2159@1|root,COG2159@2|Bacteria,1MVHB@1224|Proteobacteria,1RMYJ@1236|Gammaproteobacteria,1X45W@135614|Xanthomonadales 135614|Xanthomonadales S 4-oxalomesaconate hydratase fldW - 4.2.1.83 ko:K10220 ko00362,ko01120,map00362,map01120 - R04478 RC00498 ko00000,ko00001,ko01000 - - - Amidohydro_2 k59_1249748_1 1218352.B597_018425 1.77e-43 153.0 COG2710@1|root,COG2710@2|Bacteria,1MWSX@1224|Proteobacteria,1RPBI@1236|Gammaproteobacteria,1Z2NK@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria C Belongs to the NifD NifK NifE NifN family nifN - - ko:K02592 - - - - ko00000 - - - Oxidored_nitro k59_1249748_2 1056820.KB900674_gene2580 8.21e-52 176.0 COG2710@1|root,COG2710@2|Bacteria,1MWAJ@1224|Proteobacteria,1RQ8X@1236|Gammaproteobacteria,2PQBB@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria C Nitrogenase component 1 type Oxidoreductase nifE - - ko:K02587 - - - - ko00000 - - - Oxidored_nitro k59_1362908_1 1333998.M2A_0558 5.64e-75 240.0 COG0651@1|root,COG0651@2|Bacteria,1QU5Z@1224|Proteobacteria,2U1B0@28211|Alphaproteobacteria,4BPJI@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria CP Proton-conducting membrane transporter nuoL2 - 1.6.5.3 ko:K00341,ko:K05568 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000,ko02000 2.A.63.1,2.A.63.2,3.D.1 - - Proton_antipo_M,Proton_antipo_N k59_402339_1 317025.Tcr_0615 5.49e-28 108.0 COG0565@1|root,COG0565@2|Bacteria,1N47Y@1224|Proteobacteria,1RPD3@1236|Gammaproteobacteria,460FF@72273|Thiotrichales 72273|Thiotrichales J Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA trmJ - 2.1.1.200 ko:K02533,ko:K15396 - - - - ko00000,ko01000,ko03016 - - - SpoU_methylase k59_402339_2 589865.DaAHT2_0139 2.87e-05 47.4 COG0483@1|root,COG0483@2|Bacteria,1MUQT@1224|Proteobacteria,42R1W@68525|delta/epsilon subdivisions,2WMQ4@28221|Deltaproteobacteria,2MJPN@213118|Desulfobacterales 28221|Deltaproteobacteria G PFAM Inositol monophosphatase suhB - 3.1.3.25 ko:K01092 ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070 M00131 R01185,R01186,R01187 RC00078 ko00000,ko00001,ko00002,ko01000 - - - Inositol_P k59_741527_1 1122137.AQXF01000003_gene2329 3.25e-134 388.0 COG0418@1|root,COG0418@2|Bacteria,1MUYP@1224|Proteobacteria,2TT2U@28211|Alphaproteobacteria 28211|Alphaproteobacteria F Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate pyrC - 3.5.2.3 ko:K01465 ko00240,ko01100,map00240,map01100 M00051 R01993 RC00632 ko00000,ko00001,ko00002,ko01000 - - - Amidohydro_1 k59_854790_1 1382356.JQMP01000003_gene1605 3.47e-120 376.0 COG0209@1|root,COG0209@2|Bacteria,2G8RN@200795|Chloroflexi,27Y2V@189775|Thermomicrobia 189775|Thermomicrobia F Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen - - 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - Ribonuc_red_2_N,Ribonuc_red_lgC k59_402344_1 1380390.JIAT01000014_gene6208 2.36e-33 132.0 COG2909@1|root,COG2909@2|Bacteria 2|Bacteria K trisaccharide binding - - - - - - - - - - - - CbiA,NB-ARC,Response_reg,TIR_2,TPR_10,TPR_12 k59_1588442_1 1366050.N234_10720 4.24e-29 110.0 COG0726@1|root,COG0726@2|Bacteria,1MV3V@1224|Proteobacteria,2VJQR@28216|Betaproteobacteria,1K1KN@119060|Burkholderiaceae 28216|Betaproteobacteria G PFAM polysaccharide deacetylase - - - - - - - - - - - - Polysacc_deac_1 k59_1588442_2 1054213.HMPREF9946_00179 7.73e-39 144.0 COG0477@1|root,COG2814@2|Bacteria,1R7EW@1224|Proteobacteria,2TXMM@28211|Alphaproteobacteria,2JW1M@204441|Rhodospirillales 204441|Rhodospirillales EGP Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 k59_571586_1 436308.Nmar_0971 1.66e-97 292.0 COG0668@1|root,arCOG01568@2157|Archaea,41T3B@651137|Thaumarchaeota 651137|Thaumarchaeota M Mechanosensitive ion channel - - - - - - - - - - - - MS_channel k59_571586_2 1229909.NSED_05605 7.91e-12 66.6 COG2430@1|root,arCOG01766@2157|Archaea,41T8S@651137|Thaumarchaeota 651137|Thaumarchaeota S Protein of unknown function (DUF432) - - - ko:K09149 - - - - ko00000 - - - DUF432 k59_120358_1 314287.GB2207_02292 2.68e-42 147.0 COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,1RNJ1@1236|Gammaproteobacteria,1J5P8@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria EP Binding-protein-dependent transport system inner membrane component oppB GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0016020,GO:0022857,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944 - ko:K15581 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00439 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 - - BPD_transp_1 k59_289970_1 222534.KB893670_gene3882 2.11e-09 61.2 COG3507@1|root,COG3507@2|Bacteria 2|Bacteria G Belongs to the glycosyl hydrolase 43 family - - - ko:K20276 ko02024,map02024 - - - ko00000,ko00001 - - - Glyco_hyd_101C,Glyco_hydro_101,Glyco_hydro_43,NPCBM,NPCBM_assoc,RicinB_lectin_2 k59_289970_2 1126627.BAWE01000004_gene4718 1.41e-34 132.0 COG4772@1|root,COG4772@2|Bacteria,1MUIH@1224|Proteobacteria,2TRPJ@28211|Alphaproteobacteria,3JRAT@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria P TonB-dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_571595_1 1122185.N792_13500 5.18e-69 221.0 COG4974@1|root,COG4974@2|Bacteria,1MVAN@1224|Proteobacteria,1RMSS@1236|Gammaproteobacteria,1X3FD@135614|Xanthomonadales 135614|Xanthomonadales L Belongs to the 'phage' integrase family - - - - - - - - - - - - Phage_int_SAM_4,Phage_integrase k59_176368_1 1121937.AUHJ01000012_gene2773 2.3e-61 214.0 COG0591@1|root,COG4191@1|root,COG0591@2|Bacteria,COG4191@2|Bacteria,1QTSW@1224|Proteobacteria,1T1G2@1236|Gammaproteobacteria,4643M@72275|Alteromonadaceae 1236|Gammaproteobacteria T COG0591 Na proline symporter cbrA - - - - - - - - - - - HATPase_c,HisKA,PAS k59_1701609_1 1384054.N790_03180 7.49e-21 96.3 COG0154@1|root,COG3391@1|root,COG0154@2|Bacteria,COG3391@2|Bacteria,1MUVQ@1224|Proteobacteria,1RP7E@1236|Gammaproteobacteria,1X4K6@135614|Xanthomonadales 135614|Xanthomonadales J Catalyzes the hydrolysis of a monocarboxylic acid amid to form a monocarboxylate and ammonia gatAX - 3.5.1.4 ko:K01426 ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120 - R02540,R03096,R03180,R03909,R05551,R05590 RC00010,RC00100,RC00950,RC01025 ko00000,ko00001,ko01000 - - - Amidase,Lipocalin_5 k59_1588456_1 47839.CCAU010000004_gene914 2.82e-47 159.0 COG0491@1|root,COG0491@2|Bacteria,2GNS6@201174|Actinobacteria,2344Z@1762|Mycobacteriaceae 201174|Actinobacteria S Metallo-beta-lactamase superfamily gloB GO:0003674,GO:0003824,GO:0004416,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0005829,GO:0006082,GO:0006090,GO:0006518,GO:0006575,GO:0006749,GO:0006750,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016787,GO:0016788,GO:0016790,GO:0019184,GO:0019752,GO:0031974,GO:0032787,GO:0034641,GO:0042398,GO:0043043,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0051186,GO:0051188,GO:0070013,GO:0071704,GO:1901564,GO:1901566,GO:1901576 - - - - - - - - - - Lactamase_B k59_1588456_2 159450.NH14_09380 1.39e-08 56.6 COG2086@1|root,COG2086@2|Bacteria,1MYID@1224|Proteobacteria,2W131@28216|Betaproteobacteria 28216|Betaproteobacteria C Electron transfer flavoprotein domain - - - ko:K03521 - - - - ko00000 - - - ETF k59_854809_1 1207055.C100_08390 2.25e-55 194.0 COG4774@1|root,COG4774@2|Bacteria,1NMCN@1224|Proteobacteria,2TVPT@28211|Alphaproteobacteria,2K2IS@204457|Sphingomonadales 204457|Sphingomonadales P TonB-dependent receptor - - - - - - - - - - - - Plug,TonB_dep_Rec k59_8200_2 1307759.JOMJ01000003_gene2260 4.87e-26 108.0 COG2853@1|root,COG2853@2|Bacteria,1MVX0@1224|Proteobacteria,42RII@68525|delta/epsilon subdivisions,2WNS9@28221|Deltaproteobacteria,2MA33@213115|Desulfovibrionales 28221|Deltaproteobacteria M PFAM VacJ family lipoprotein - - - ko:K04754 - - - - ko00000 - - - MlaA k59_177155_1 1044.EH31_05425 2.06e-22 100.0 COG0642@1|root,COG0642@2|Bacteria,1NXDJ@1224|Proteobacteria,2TW2Q@28211|Alphaproteobacteria 28211|Alphaproteobacteria T Histidine kinase - - - - - - - - - - - - HATPase_c,HisKA,Hpt,PAS_8,Response_reg k59_233589_2 1121022.ABENE_17985 2.08e-09 61.6 COG2819@1|root,COG2819@2|Bacteria,1RB1X@1224|Proteobacteria,2U9NE@28211|Alphaproteobacteria,2KJ56@204458|Caulobacterales 204458|Caulobacterales S Putative esterase - - - ko:K07017 - - - - ko00000 - - - Esterase k59_911909_1 1122137.AQXF01000006_gene876 6.23e-44 149.0 COG0061@1|root,COG0061@2|Bacteria,1MUBC@1224|Proteobacteria,2TSKN@28211|Alphaproteobacteria 28211|Alphaproteobacteria H Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP nadK - 2.7.1.23 ko:K00858 ko00760,ko01100,map00760,map01100 - R00104 RC00002,RC00078 ko00000,ko00001,ko01000 - - - NAD_kinase k59_911909_2 1122137.AQXF01000006_gene875 3.35e-63 202.0 COG2896@1|root,COG2896@2|Bacteria,1MW3W@1224|Proteobacteria,2TQQP@28211|Alphaproteobacteria 28211|Alphaproteobacteria H Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate moaA - 4.1.99.22 ko:K03639 ko00790,ko01100,ko04122,map00790,map01100,map04122 - R09394 RC03420 ko00000,ko00001,ko01000 - - - Fer4_12,Mob_synth_C,Radical_SAM k59_1250690_1 398525.KB900701_gene6702 6.03e-92 291.0 COG3119@1|root,COG3119@2|Bacteria,1MV92@1224|Proteobacteria,2TTXG@28211|Alphaproteobacteria,3JVJZ@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria P Sulfatase - - 3.1.6.1 ko:K01130 ko00140,ko00600,map00140,map00600 - R03980,R04856 RC00128,RC00231 ko00000,ko00001,ko01000 - - - Sulfatase k59_1482345_1 436308.Nmar_0295 3.86e-99 304.0 COG1245@1|root,arCOG00187@2157|Archaea,41S8K@651137|Thaumarchaeota 651137|Thaumarchaeota E RNase L inhibitor, RLI - - - ko:K06174 - - - - ko00000,ko03009 - - - ABC_tran,Fer4,RLI k59_1085703_1 237368.SCABRO_03854 4.7e-30 125.0 COG2909@1|root,COG2909@2|Bacteria 2|Bacteria K trisaccharide binding - - - - - - - - - - - - BTAD,Trans_reg_C k59_125931_1 330214.NIDE0849 4.18e-94 279.0 COG0526@1|root,COG0526@2|Bacteria,3J0SG@40117|Nitrospirae 40117|Nitrospirae CO Thioredoxin-like - - - - - - - - - - - - AhpC-TSA k59_125934_1 1121937.AUHJ01000001_gene474 3.01e-212 600.0 COG0493@1|root,COG1143@1|root,COG0493@2|Bacteria,COG1143@2|Bacteria,1MU2H@1224|Proteobacteria,1RMY7@1236|Gammaproteobacteria,464UQ@72275|Alteromonadaceae 1236|Gammaproteobacteria E COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductases - - 1.4.1.13,1.4.1.14 ko:K00266 ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 - R00093,R00114,R00248 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - DHODB_Fe-S_bind,Fer4_20,Fer4_7,NAD_binding_1,Pyr_redox_2 k59_804073_1 1248232.BANQ01000075_gene1578 7.57e-32 126.0 COG0815@1|root,COG0815@2|Bacteria,1MUBU@1224|Proteobacteria,1RM8M@1236|Gammaproteobacteria,1XSXY@135623|Vibrionales 135623|Vibrionales M Transfers the fatty acyl group on membrane lipoproteins lnt GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0071704,GO:1901564 - ko:K03820 - - - - ko00000,ko01000 - GT2 - CN_hydrolase k59_1369122_1 1144305.PMI02_03857 1.77e-98 292.0 COG1028@1|root,COG1028@2|Bacteria,1MU5Y@1224|Proteobacteria,2TRNQ@28211|Alphaproteobacteria,2K2A6@204457|Sphingomonadales 204457|Sphingomonadales IQ Belongs to the short-chain dehydrogenases reductases (SDR) family - - 1.1.1.30 ko:K00019 ko00072,ko00650,ko01100,map00072,map00650,map01100 M00088 R01361 RC00117 ko00000,ko00001,ko00002,ko01000 - - - adh_short,adh_short_C2 k59_1312551_1 84531.JMTZ01000141_gene1684 1.32e-14 78.6 COG3325@1|root,COG3325@2|Bacteria,1MWAR@1224|Proteobacteria,1RPNS@1236|Gammaproteobacteria,1X5BZ@135614|Xanthomonadales 135614|Xanthomonadales G chitinase - - 3.2.1.14 ko:K01183 ko00520,ko01100,map00520,map01100 - R01206,R02334 RC00467 ko00000,ko00001,ko01000 - GH18 - Calx-beta,Glyco_hydro_18,fn3 k59_1424688_1 1313172.YM304_26210 8.9e-87 279.0 COG0045@1|root,COG1042@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,2GKN1@201174|Actinobacteria,4CMW5@84992|Acidimicrobiia 201174|Actinobacteria CJ CoA binding domain acdA1 - - - - - - - - - - - ATP-grasp_5,CoA_binding_2,Succ_CoA_lig k59_1424688_2 1229780.BN381_410015 6.28e-20 86.7 COG0045@1|root,COG0045@2|Bacteria,2I3K9@201174|Actinobacteria 201174|Actinobacteria C ATP-grasp domain - - - - - - - - - - - - ATP-grasp_5 k59_804078_1 1088721.NSU_2415 3.41e-111 334.0 COG4372@1|root,COG4372@2|Bacteria,1MUCX@1224|Proteobacteria,2TR59@28211|Alphaproteobacteria,2KEBT@204457|Sphingomonadales 204457|Sphingomonadales L zinc-finger binding domain of transposase IS66 - - - - - - - - - - - - DDE_Tnp_IS66,DDE_Tnp_IS66_C,LZ_Tnp_IS66,zf-IS66 k59_1085725_2 565045.NOR51B_1038 2.04e-70 223.0 COG0500@1|root,COG0500@2|Bacteria,1QXXN@1224|Proteobacteria,1T3JG@1236|Gammaproteobacteria 1236|Gammaproteobacteria Q Met-10+ like-protein - - - - - - - - - - - - Methyltransf_25 k59_13003_1 1380356.JNIK01000004_gene14 1.05e-75 253.0 COG1529@1|root,COG1529@2|Bacteria,2GIVI@201174|Actinobacteria,4ERP5@85013|Frankiales 201174|Actinobacteria C aldehyde oxidase and xanthine dehydrogenase, a b hammerhead - - - - - - - - - - - - Ald_Xan_dh_C,Ald_Xan_dh_C2 k59_1482366_1 153721.MYP_3420 1.03e-87 270.0 COG3328@1|root,COG3328@2|Bacteria,4NFQS@976|Bacteroidetes,47NSF@768503|Cytophagia 976|Bacteroidetes L Transposase, Mutator family - - - - - - - - - - - - Transposase_mut k59_125949_1 1121028.ARQE01000003_gene810 5.68e-96 290.0 COG0183@1|root,COG0183@2|Bacteria,1MUZV@1224|Proteobacteria,2TRHF@28211|Alphaproteobacteria,2PM4G@255475|Aurantimonadaceae 28211|Alphaproteobacteria I acetyl-coa acetyltransferase - - - - - - - - - - - - Thiolase_C k59_408245_1 502025.Hoch_3378 5.91e-81 250.0 COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,42MV1@68525|delta/epsilon subdivisions,2WM7T@28221|Deltaproteobacteria,2YUI5@29|Myxococcales 28221|Deltaproteobacteria V ABC transporter - - - ko:K01990,ko:K09695 ko02010,map02010 M00252,M00254 - - ko00000,ko00001,ko00002,ko02000 3.A.1,3.A.1.102 - - ABC_tran,DUF4162 k59_1369148_1 1121022.ABENE_14185 6.5e-40 149.0 COG1629@1|root,COG1629@2|Bacteria,1MV8W@1224|Proteobacteria,2U0EP@28211|Alphaproteobacteria,2KG7M@204458|Caulobacterales 204458|Caulobacterales P receptor - - - - - - - - - - - - Plug,TonB_dep_Rec k59_352188_1 1265313.HRUBRA_01817 3.41e-112 332.0 COG0045@1|root,COG0045@2|Bacteria,1MVCE@1224|Proteobacteria,1RMSU@1236|Gammaproteobacteria,1J53T@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria F Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit sucC GO:0003674,GO:0003824,GO:0004774,GO:0004775,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016874,GO:0016877,GO:0016878,GO:0016999,GO:0017144,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0055114,GO:0071704,GO:0072350 6.2.1.5,6.2.1.9 ko:K01903,ko:K14067 ko00020,ko00630,ko00640,ko00660,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00630,map00640,map00660,map00680,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00346,M00374,M00620 R00405,R01256,R02404 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000 - - - ATP-grasp_2,Ligase_CoA k59_464488_1 83219.PM02_09420 1.61e-35 143.0 COG2114@1|root,COG3899@1|root,COG2114@2|Bacteria,COG3899@2|Bacteria,1MUDT@1224|Proteobacteria,2TQVN@28211|Alphaproteobacteria,3ZY2S@60136|Sulfitobacter 28211|Alphaproteobacteria T Sterile alpha motif. - - - - - - - - - - - - AAA_16,DZR,Guanylate_cyc,SAM_1,SAM_2 k59_916503_1 525904.Tter_1979 9.78e-27 109.0 COG2084@1|root,COG2084@2|Bacteria,2NP96@2323|unclassified Bacteria 2|Bacteria I NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase MA20_29235 - 1.1.1.31 ko:K00020 ko00280,ko01100,map00280,map01100 - R05066 RC00099 ko00000,ko00001,ko01000 - - - NAD_binding_11,NAD_binding_2 k59_861029_1 158500.BV97_02731 4.59e-94 286.0 2CC90@1|root,33XAD@2|Bacteria,1MYKP@1224|Proteobacteria,2UAV3@28211|Alphaproteobacteria,2K1DP@204457|Sphingomonadales 204457|Sphingomonadales - - - - - - - - - - - - - - - k59_1538388_1 1121013.P873_03010 1.3e-05 47.8 COG4105@1|root,COG4105@2|Bacteria,1MVS5@1224|Proteobacteria,1RSE6@1236|Gammaproteobacteria,1X347@135614|Xanthomonadales 135614|Xanthomonadales M Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane bamD - - ko:K05807 - - - - ko00000,ko02000 1.B.33.1 - - YfiO k59_1538388_2 713587.THITH_00370 1.64e-23 103.0 COG0457@1|root,COG0457@2|Bacteria,1R50I@1224|Proteobacteria,1RSP6@1236|Gammaproteobacteria,1WY6N@135613|Chromatiales 135613|Chromatiales S Tetratricopeptide repeat - - - - - - - - - - - - - k59_633990_1 439481.Aboo_1385 2.2e-35 136.0 COG0433@1|root,arCOG00280@2157|Archaea,2Y7MA@28890|Euryarchaeota,3F30Q@33867|unclassified Euryarchaeota 28890|Euryarchaeota L AAA-like domain - - - ko:K06915 - - - - ko00000 - - - DUF87,HAS-barrel k59_464502_1 1306990.BARG01000018_gene1651 3.53e-09 63.5 COG0834@1|root,COG0834@2|Bacteria,2GJH8@201174|Actinobacteria 201174|Actinobacteria ET Belongs to the bacterial solute-binding protein 3 family - - - ko:K02030 - M00236 - - ko00000,ko00002,ko02000 3.A.1.3 - - SBP_bac_3 k59_972323_1 467481.B0VK40_9CAUD 5.76e-55 193.0 4QC1K@10239|Viruses,4QVDN@35237|dsDNA viruses no RNA stage,4QPY0@28883|Caudovirales,4QKQE@10699|Siphoviridae 10699|Siphoviridae - - - - - - - - - - - - - - - k59_972323_4 883.DvMF_1643 1.66e-21 109.0 COG3941@1|root,COG3941@2|Bacteria,1RM44@1224|Proteobacteria,42YXN@68525|delta/epsilon subdivisions,2WUIP@28221|Deltaproteobacteria,2MBZS@213115|Desulfovibrionales 28221|Deltaproteobacteria S tape measure - - - - - - - - - - - - Tape_meas_lam_C k59_634004_1 1123269.NX02_12910 2.02e-34 130.0 COG1459@1|root,COG1459@2|Bacteria,1MV4U@1224|Proteobacteria,2TV76@28211|Alphaproteobacteria,2K0ZH@204457|Sphingomonadales 204457|Sphingomonadales U General secretion pathway protein F gspF - - ko:K02455 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - T2SSF k59_238353_1 1196029.ALIM01000034_gene1735 0.000857 46.6 COG0778@1|root,COG0778@2|Bacteria,1UB8S@1239|Firmicutes,4HEGP@91061|Bacilli,1ZDZI@1386|Bacillus 91061|Bacilli C Nitroreductase family - - 1.5.1.39 ko:K10678,ko:K19286 ko00633,ko00740,ko01100,ko01120,map00633,map00740,map01100,map01120 - R05705,R05706,R08014,R08017,R08042 RC00126,RC00250 ko00000,ko00001,ko01000 - - - Nitroreductase k59_238353_2 1198452.Jab_1c15890 6.32e-12 66.2 COG0796@1|root,COG0796@2|Bacteria,1NAI2@1224|Proteobacteria,2VQ46@28216|Betaproteobacteria,472PC@75682|Oxalobacteraceae 28216|Betaproteobacteria M Provides the (R)-glutamate required for cell wall biosynthesis murI - 5.1.1.3 ko:K01776 ko00471,ko01100,map00471,map01100 - R00260 RC00302 ko00000,ko00001,ko01000,ko01011 - - - Asp_Glu_race k59_916527_1 1088721.NSU_0845 9.39e-126 385.0 COG4773@1|root,COG4773@2|Bacteria,1MWUQ@1224|Proteobacteria,2TTVU@28211|Alphaproteobacteria,2K1ZQ@204457|Sphingomonadales 204457|Sphingomonadales P COG1629 Outer membrane receptor proteins, mostly Fe transport - - - - - - - - - - - - Plug,TonB_dep_Rec k59_1085788_1 436308.Nmar_0387 1.1e-112 329.0 COG1650@1|root,arCOG01616@2157|Archaea,41SM3@651137|Thaumarchaeota 651137|Thaumarchaeota J D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo dtdA - 3.1.1.96 ko:K09716 - - - - ko00000,ko01000,ko03016 - - - tRNA_deacylase k59_13033_1 1082933.MEA186_02599 9.61e-47 168.0 COG4992@1|root,COG4992@2|Bacteria,1MV3C@1224|Proteobacteria,2TSGT@28211|Alphaproteobacteria,43H9S@69277|Phyllobacteriaceae 28211|Alphaproteobacteria E acetylornithine aminotransferase argD GO:0003674,GO:0005488,GO:0005515,GO:0008144,GO:0019842,GO:0030170,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0048037,GO:0050662,GO:0070279,GO:0097159,GO:1901363 2.6.1.11,2.6.1.17 ko:K00821 ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00028,M00845 R02283,R04475 RC00006,RC00062 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 k59_13033_2 743299.Acife_3085 7.79e-47 167.0 COG0002@1|root,COG0002@2|Bacteria,1MVJ6@1224|Proteobacteria,1RNMX@1236|Gammaproteobacteria,2NC20@225057|Acidithiobacillales 225057|Acidithiobacillales E Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde argC - 1.2.1.38 ko:K00145 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028,M00845 R03443 RC00684 ko00000,ko00001,ko00002,ko01000 - - - Semialdhyde_dh,Semialdhyde_dhC k59_1651289_1 1123367.C666_01960 2.83e-85 271.0 COG0021@1|root,COG0021@2|Bacteria,1MUEY@1224|Proteobacteria,2VHNX@28216|Betaproteobacteria,2KV91@206389|Rhodocyclales 206389|Rhodocyclales H Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate tkt - 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 - - - Transket_pyr,Transketolase_C,Transketolase_N k59_1199086_1 367336.OM2255_13489 2.64e-06 48.1 COG1249@1|root,COG1249@2|Bacteria,1MU2Z@1224|Proteobacteria,2TQS7@28211|Alphaproteobacteria 28211|Alphaproteobacteria C Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family gor GO:0000166,GO:0000302,GO:0000305,GO:0003674,GO:0005488,GO:0005507,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0006950,GO:0006979,GO:0008144,GO:0008150,GO:0009507,GO:0009532,GO:0009536,GO:0009570,GO:0009987,GO:0010035,GO:0017076,GO:0019725,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042221,GO:0042592,GO:0043167,GO:0043168,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0045454,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0065007,GO:0065008,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901700 1.8.1.7 ko:K00383 ko00480,ko04918,map00480,map04918 - R00094,R00115 RC00011 ko00000,ko00001,ko01000 - - - Pyr_redox_2,Pyr_redox_dim k59_1199086_2 1415778.JQMM01000001_gene1740 2.19e-166 478.0 COG0007@1|root,COG1648@1|root,COG0007@2|Bacteria,COG1648@2|Bacteria,1MUI0@1224|Proteobacteria,1RM9V@1236|Gammaproteobacteria,1J4IM@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme cysG - 1.3.1.76,2.1.1.107,4.99.1.4 ko:K02302,ko:K02303 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R02864,R03194,R03947 RC00003,RC00871,RC01012,RC01034 ko00000,ko00001,ko00002,ko01000 - - iJN746.PP_3999 CysG_dimeriser,NAD_binding_7,Sirohm_synth_M,TP_methylase k59_634031_1 331869.BAL199_20640 8.31e-39 143.0 COG2271@1|root,COG2271@2|Bacteria,1QU9E@1224|Proteobacteria,2TWHH@28211|Alphaproteobacteria 28211|Alphaproteobacteria G Major facilitator superfamily MA20_22860 - - - - - - - - - - - MFS_1 k59_1764022_1 983917.RGE_01290 2.55e-11 71.6 COG1028@1|root,COG1028@2|Bacteria,1MWB6@1224|Proteobacteria,2VIXS@28216|Betaproteobacteria 28216|Betaproteobacteria IQ Belongs to the short-chain dehydrogenases reductases (SDR) family - - 1.1.1.100,1.1.1.47,1.1.1.69,1.3.1.28 ko:K00034,ko:K00046,ko:K00059,ko:K00216 ko00030,ko00061,ko00333,ko00780,ko01040,ko01053,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00030,map00061,map00333,map00780,map01040,map01053,map01100,map01110,map01120,map01130,map01200,map01212 M00083,M00572 R01505,R01520,R01521,R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00066,RC00117,RC00534 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 k59_1030521_1 358220.C380_02845 1.82e-13 70.9 COG3576@1|root,COG3576@2|Bacteria,1N8Z5@1224|Proteobacteria,2VVVW@28216|Betaproteobacteria,4AEMH@80864|Comamonadaceae 28216|Betaproteobacteria S pyridoxamine 5-phosphate - - - - - - - - - - - - - k59_408300_1 215803.DB30_4063 1.9e-106 328.0 COG3653@1|root,COG3653@2|Bacteria,1MWWY@1224|Proteobacteria,42PGV@68525|delta/epsilon subdivisions,2WIS0@28221|Deltaproteobacteria,2YZVC@29|Myxococcales 28221|Deltaproteobacteria Q Amidohydrolase family - - 3.5.1.81 ko:K06015 - - R02192 RC00064,RC00328 ko00000,ko01000 - - - Amidohydro_3 k59_408300_2 1287276.X752_01115 9.34e-28 108.0 COG0491@1|root,COG0491@2|Bacteria,1MU8Q@1224|Proteobacteria,2TSVS@28211|Alphaproteobacteria,43I0A@69277|Phyllobacteriaceae 28211|Alphaproteobacteria S Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid gloB - 3.1.2.6 ko:K01069 ko00620,map00620 - R01736 RC00004,RC00137 ko00000,ko00001,ko01000 - - - HAGH_C,Lactamase_B k59_238377_1 1000565.METUNv1_01319 5.72e-93 283.0 COG0624@1|root,COG0624@2|Bacteria,1MW6G@1224|Proteobacteria,2VHRF@28216|Betaproteobacteria,2KUDN@206389|Rhodocyclales 206389|Rhodocyclales E Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls dapE - 3.5.1.18 ko:K01439 ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230 M00016 R02734 RC00064,RC00090 ko00000,ko00001,ko00002,ko01000 - - - M20_dimer,Peptidase_M20 k59_746763_1 1415778.JQMM01000001_gene104 1.83e-29 115.0 COG0668@1|root,COG0668@2|Bacteria,1N66N@1224|Proteobacteria,1RQWI@1236|Gammaproteobacteria,1J5R8@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Mechanosensitive ion channel - - - - - - - - - - - - MS_channel k59_1255509_1 436308.Nmar_1325 1.47e-69 226.0 arCOG07561@1|root,arCOG07561@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - TSP_3,VWA k59_1369224_1 1232410.KI421421_gene3270 1.31e-106 319.0 COG1775@1|root,COG1775@2|Bacteria,1NNW9@1224|Proteobacteria,42RTN@68525|delta/epsilon subdivisions,2WNYI@28221|Deltaproteobacteria,43V0Q@69541|Desulfuromonadales 28221|Deltaproteobacteria E 2-hydroxyglutaryl-CoA dehydratase, D-component - - 1.3.7.8 ko:K04112 ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220 M00541 R02451 RC00002,RC01839 ko00000,ko00001,ko00002,ko01000 - - - HGD-D k59_1255516_1 479431.Namu_5223 4.17e-44 159.0 COG0277@1|root,COG0277@2|Bacteria,2GJ2T@201174|Actinobacteria,4ERQV@85013|Frankiales 201174|Actinobacteria C PFAM FAD linked oxidase domain protein - - 1.1.3.15 ko:K00104 ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130 - R00475 RC00042 ko00000,ko00001,ko01000 - - - FAD-oxidase_C,FAD_binding_4 k59_972353_1 479434.Sthe_2363 8.38e-64 224.0 COG0209@1|root,COG0209@2|Bacteria,2G8RN@200795|Chloroflexi,27Y2V@189775|Thermomicrobia 189775|Thermomicrobia F Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen - - 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - Ribonuc_red_2_N,Ribonuc_red_lgC k59_408321_1 768671.ThimaDRAFT_3109 3.6e-91 278.0 COG2321@1|root,COG2321@2|Bacteria,1MU4U@1224|Proteobacteria,1RMF8@1236|Gammaproteobacteria,1WVZR@135613|Chromatiales 135613|Chromatiales S Putative neutral zinc metallopeptidase - - - ko:K07054 - - - - ko00000 - - - Zn_peptidase k59_746780_1 589865.DaAHT2_0263 1.89e-155 475.0 COG0741@1|root,COG1388@1|root,COG0741@2|Bacteria,COG1388@2|Bacteria,1MWKE@1224|Proteobacteria,42QM3@68525|delta/epsilon subdivisions,2WKI2@28221|Deltaproteobacteria,2MI4S@213118|Desulfobacterales 28221|Deltaproteobacteria M Lysin motif - - - ko:K08307 - - - - ko00000,ko01000,ko01011 - - - LysM,SLT k59_746780_2 745014.OMB55_00012270 5.78e-92 284.0 COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,1RMMJ@1236|Gammaproteobacteria,1J5DF@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C COG1960 Acyl-CoA dehydrogenases ivd - 1.3.8.4 ko:K00253 ko00280,ko01100,map00280,map01100 M00036 R04095 RC00246 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_1538467_1 999541.bgla_1g05470 2.77e-89 276.0 COG0773@1|root,COG0773@2|Bacteria,1MUC5@1224|Proteobacteria,2VIX5@28216|Betaproteobacteria,1K14Y@119060|Burkholderiaceae 28216|Betaproteobacteria M Reutilizes the intact tripeptide L-alanyl-gamma-D- glutamyl-meso-diaminopimelate by linking it to UDP-N- acetylmuramate mpl - 6.3.2.45 ko:K02558 - - - - ko00000,ko01000 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_690578_1 504487.JCM19302_1527 5.17e-22 95.1 COG0457@1|root,COG2972@1|root,COG0457@2|Bacteria,COG2972@2|Bacteria,4NF45@976|Bacteroidetes,1HXUR@117743|Flavobacteriia 976|Bacteroidetes T Histidine kinase - - - - - - - - - - - - His_kinase,SNAP,TPR_12,TPR_16,TPR_7,TPR_8 k59_804171_1 261292.Nit79A3_3200 1.25e-61 219.0 COG1629@1|root,COG4771@2|Bacteria,1MUC1@1224|Proteobacteria,2VH4X@28216|Betaproteobacteria,374R9@32003|Nitrosomonadales 28216|Betaproteobacteria P PFAM TonB-dependent receptor, plug - - - ko:K02014,ko:K16089 - - - - ko00000,ko02000 1.B.14,1.B.14.1,1.B.14.10 - - Plug,TonB_dep_Rec k59_1708193_1 1117315.AHCA01000001_gene2392 1.6e-96 294.0 COG2017@1|root,COG2017@2|Bacteria,1MVMN@1224|Proteobacteria,1RNZN@1236|Gammaproteobacteria,2Q27A@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria G Converts alpha-aldose to the beta-anomer galM - 5.1.3.3 ko:K01785 ko00010,ko00052,ko01100,ko01110,ko01120,ko01130,map00010,map00052,map01100,map01110,map01120,map01130 M00632 R01602,R10619 RC00563 ko00000,ko00001,ko00002,ko01000 - - - Aldose_epim k59_183296_1 391038.Bphy_4012 5.23e-14 72.4 COG1028@1|root,COG1028@2|Bacteria,1MX6D@1224|Proteobacteria,2VM63@28216|Betaproteobacteria,1K3DT@119060|Burkholderiaceae 28216|Betaproteobacteria IQ KR domain - - - - - - - - - - - - adh_short_C2 k59_917465_1 219305.MCAG_03179 3.71e-28 112.0 COG0852@1|root,COG0852@2|Bacteria,2GIRH@201174|Actinobacteria,4D9YC@85008|Micromonosporales 201174|Actinobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoC GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006091,GO:0008137,GO:0008150,GO:0008152,GO:0009987,GO:0015980,GO:0016491,GO:0016651,GO:0016655,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0050136,GO:0055114 1.6.5.3 ko:K00332 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_30kDa k59_1370057_2 1122137.AQXF01000003_gene1871 1.92e-31 124.0 COG0845@1|root,COG0845@2|Bacteria,1MV1T@1224|Proteobacteria,2VFH0@28211|Alphaproteobacteria 28211|Alphaproteobacteria M Barrel-sandwich domain of CusB or HlyD membrane-fusion - - - - - - - - - - - - HlyD_D23 k59_578521_1 87626.PTD2_18260 2.21e-25 107.0 COG2091@1|root,COG2091@2|Bacteria,1MY8E@1224|Proteobacteria,1RQAI@1236|Gammaproteobacteria,2PZMF@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria H Carbohydrate family 9 binding domain-like - - - - - - - - - - - - CBM9_1 k59_14036_1 316407.1736464 4.53e-29 110.0 COG3716@1|root,COG3716@2|Bacteria,1MWTZ@1224|Proteobacteria,1RNSD@1236|Gammaproteobacteria,3XNSC@561|Escherichia 1236|Gammaproteobacteria G The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II ManXYZ PTS system is involved in mannose transport. Also functions as a receptor for bacterial chemotaxis and is required for infection of the cell by bacteriophage lambda where it most likely functions as a pore for penetration of lambda DNA manZ GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0008643,GO:0008645,GO:0008982,GO:0009401,GO:0015144,GO:0015145,GO:0015149,GO:0015578,GO:0015749,GO:0015761,GO:0016020,GO:0016021,GO:0016740,GO:0016772,GO:0016773,GO:0022804,GO:0022857,GO:0022870,GO:0031224,GO:0031226,GO:0034219,GO:0044425,GO:0044459,GO:0044464,GO:0046323,GO:0051119,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0098657,GO:0098704,GO:0098708,GO:0098739,GO:1904659 - ko:K02796 ko00051,ko00520,ko01100,ko02060,map00051,map00520,map01100,map02060 M00276 R02630 RC00017,RC03206 ko00000,ko00001,ko00002,ko02000 4.A.6.1 - iECIAI1_1343.ECIAI1_1888,iECP_1309.ECP_1762,iSBO_1134.SBO_1231,iSF_1195.SF1409,iSFxv_1172.SFxv_1596,iS_1188.S1524 EIID-AGA k59_14036_2 511145.b1820 7.19e-62 192.0 COG4811@1|root,COG4811@2|Bacteria,1RDEQ@1224|Proteobacteria,1S3UZ@1236|Gammaproteobacteria,3XMU3@561|Escherichia 1236|Gammaproteobacteria S UPF0266 membrane protein YobD yobD GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - - - - - - - - - - DUF986 k59_1652293_1 292415.Tbd_2321 1.27e-15 82.4 COG1538@1|root,COG1538@2|Bacteria,1MWX5@1224|Proteobacteria,2VHU4@28216|Betaproteobacteria 28216|Betaproteobacteria MU CyaE is necessary for transport of calmodulin-sensitive adenylate cyclase-hemolysin (cyclolysin) cyaE - - ko:K12340 ko01501,ko01503,ko02020,ko03070,ko04626,ko05133,map01501,map01503,map02020,map03070,map04626,map05133 M00325,M00326,M00339,M00571,M00575,M00646,M00647,M00696,M00697,M00709,M00720,M00821 - - ko00000,ko00001,ko00002,ko01504,ko02000,ko02044 1.B.17,2.A.6.2 - - OEP k59_1539339_1 702113.PP1Y_AT28029 3.56e-109 328.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2TQPG@28211|Alphaproteobacteria,2K0T8@204457|Sphingomonadales 204457|Sphingomonadales T Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains - - - - - - - - - - - - HTH_8,Response_reg,Sigma54_activat k59_1086879_1 984262.SGRA_0523 2.24e-68 223.0 COG3844@1|root,COG3844@2|Bacteria,4NECS@976|Bacteroidetes,1IQ2Y@117747|Sphingobacteriia 976|Bacteroidetes E Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively kynU - 3.7.1.3 ko:K01556 ko00380,ko01100,map00380,map01100 M00038 R00987,R02668,R03936 RC00284,RC00415 ko00000,ko00001,ko00002,ko01000 - - - Aminotran_5 k59_1652298_1 322710.Avin_51890 2.36e-74 241.0 COG0449@1|root,COG0449@2|Bacteria,1MW4K@1224|Proteobacteria,1RMVN@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source glmS GO:0003674,GO:0003824,GO:0004360,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006002,GO:0006040,GO:0006047,GO:0006048,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009226,GO:0009987,GO:0016740,GO:0016769,GO:0018130,GO:0019438,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0034654,GO:0036211,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046349,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.6.1.16 ko:K00820 ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931 - R00768 RC00010,RC00163,RC02752 ko00000,ko00001,ko01000,ko01002 - - iE2348C_1286.E2348C_4039,iEC042_1314.EC042_4115,iECIAI39_1322.ECIAI39_4333,iECNA114_1301.ECNA114_3878,iECOK1_1307.ECOK1_4178,iECSF_1327.ECSF_3577,iECUMN_1333.ECUMN_4259,iEcSMS35_1347.EcSMS35_4097,iLF82_1304.LF82_0844,iNRG857_1313.NRG857_18570,iSFV_1184.SFV_3755,iSF_1195.SF3809,iSFxv_1172.SFxv_4151,iS_1188.S3959,iUMN146_1321.UM146_18835,iUTI89_1310.UTI89_C4281 GATase_6,SIS k59_1370063_1 1122137.AQXF01000006_gene803 6.02e-140 397.0 COG0603@1|root,COG0603@2|Bacteria,1MU5V@1224|Proteobacteria,2TU7F@28211|Alphaproteobacteria 28211|Alphaproteobacteria F Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) queC - 6.3.4.20 ko:K06920 ko00790,ko01100,map00790,map01100 - R09978 RC00959 ko00000,ko00001,ko01000,ko03016 - - - QueC k59_1708225_2 1463821.JOGR01000001_gene1512 4.69e-21 93.2 COG1816@1|root,COG1816@2|Bacteria,2GJ6I@201174|Actinobacteria,4EXXP@85014|Glycomycetales 201174|Actinobacteria F Adenosine/AMP deaminase add GO:0003674,GO:0003824,GO:0004000,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006144,GO:0006152,GO:0006154,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009112,GO:0009113,GO:0009116,GO:0009119,GO:0009163,GO:0009164,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0017144,GO:0018130,GO:0019239,GO:0019438,GO:0019439,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0042278,GO:0042440,GO:0042451,GO:0042454,GO:0042455,GO:0042737,GO:0043094,GO:0043096,GO:0043101,GO:0043103,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046085,GO:0046100,GO:0046101,GO:0046102,GO:0046103,GO:0046112,GO:0046128,GO:0046129,GO:0046130,GO:0046148,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0072523,GO:1901135,GO:1901136,GO:1901137,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901657,GO:1901658,GO:1901659 3.5.4.4 ko:K01488 ko00230,ko01100,ko05340,map00230,map01100,map05340 - R01560,R02556 RC00477 ko00000,ko00001,ko01000 - - - A_deaminase k59_1370065_1 1122137.AQXF01000002_gene503 1.51e-136 393.0 COG0142@1|root,COG0142@2|Bacteria,1MWNG@1224|Proteobacteria,2TR79@28211|Alphaproteobacteria 28211|Alphaproteobacteria H Belongs to the FPP GGPP synthase family ispA GO:0003674,GO:0003824,GO:0004311,GO:0004659,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006629,GO:0006644,GO:0006720,GO:0006721,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009536,GO:0009842,GO:0009987,GO:0016114,GO:0016740,GO:0016765,GO:0019637,GO:0033385,GO:0033386,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0090407,GO:1901576 2.5.1.1,2.5.1.10 ko:K00795 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00364 R01658,R02003 RC00279 ko00000,ko00001,ko00002,ko01000,ko01006 - - - polyprenyl_synt k59_1370065_2 1122137.AQXF01000002_gene504 1.14e-34 120.0 COG1722@1|root,COG1722@2|Bacteria,1PTYQ@1224|Proteobacteria,2UFD6@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides xseB - 3.1.11.6 ko:K03602 ko03430,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - Exonuc_VII_S k59_1370065_3 1122137.AQXF01000002_gene505 2.49e-59 196.0 COG0491@1|root,COG0491@2|Bacteria,1MUXF@1224|Proteobacteria,2TSYY@28211|Alphaproteobacteria 28211|Alphaproteobacteria S COG0491 Zn-dependent hydrolases, including glyoxylases - - - - - - - - - - - - Lactamase_B k59_1041203_2 580332.Slit_2649 3.95e-53 172.0 COG2010@1|root,COG2010@2|Bacteria,1NYI2@1224|Proteobacteria 1224|Proteobacteria C Cytochrome c - - - - - - - - - - - - Cytochrom_C k59_1492745_1 1040987.AZUY01000003_gene3599 5.45e-37 142.0 COG0404@1|root,COG0665@1|root,COG0404@2|Bacteria,COG0665@2|Bacteria,1MUXJ@1224|Proteobacteria,2TRGS@28211|Alphaproteobacteria,43IB9@69277|Phyllobacteriaceae 28211|Alphaproteobacteria E Belongs to the GcvT family Sardh GO:0000166,GO:0001505,GO:0003674,GO:0003824,GO:0005488,GO:0005542,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0006082,GO:0006520,GO:0006575,GO:0006576,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008480,GO:0009056,GO:0009063,GO:0009308,GO:0009310,GO:0009987,GO:0016054,GO:0016491,GO:0016645,GO:0019695,GO:0019752,GO:0019842,GO:0031406,GO:0031974,GO:0033218,GO:0034641,GO:0035999,GO:0036094,GO:0042133,GO:0042135,GO:0042219,GO:0042402,GO:0042426,GO:0042558,GO:0043167,GO:0043168,GO:0043177,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0043603,GO:0044106,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046395,GO:0046483,GO:0046653,GO:0046997,GO:0048037,GO:0050660,GO:0050662,GO:0051186,GO:0055114,GO:0065007,GO:0065008,GO:0070013,GO:0071704,GO:0072341,GO:0097159,GO:0097164,GO:1901052,GO:1901053,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 1.5.3.19 ko:K19191 ko00760,ko01120,map00760,map01120 - R10102 RC00060,RC00557 ko00000,ko00001,ko01000 - - - DAO,FAO_M,GCV_T,GCV_T_C k59_701033_1 1121374.KB891576_gene658 1.72e-43 164.0 COG3193@1|root,COG3193@2|Bacteria,1R3RC@1224|Proteobacteria,1S0DK@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Haem-degrading - - - - - - - - - - - - Haem_degrading k59_362970_1 755731.Clo1100_1376 7.04e-30 115.0 arCOG09511@1|root,2Z9DH@2|Bacteria,1VQHV@1239|Firmicutes,249XI@186801|Clostridia,36H8E@31979|Clostridiaceae 186801|Clostridia S PFAM FRG domain - - - - - - - - - - - - FRG k59_306309_1 1122194.AUHU01000002_gene2960 5.32e-57 193.0 COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,1RSDZ@1236|Gammaproteobacteria,466QT@72275|Alteromonadaceae 1236|Gammaproteobacteria T His Kinase A (phosphoacceptor) domain - - 2.7.13.3 ko:K19661 ko02020,map02020 M00772 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,HisKA,PAS,PAS_4,Response_reg k59_981585_1 465515.Mlut_07790 1.97e-17 82.0 COG1120@1|root,COG1120@2|Bacteria,2I5PA@201174|Actinobacteria,1WCNF@1268|Micrococcaceae 201174|Actinobacteria HP AAA domain, putative AbiEii toxin, Type IV TA system - - 3.6.3.34 ko:K02013 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.14 - - ABC_tran k59_1717975_1 1254432.SCE1572_46460 2.67e-26 114.0 COG3540@1|root,COG3540@2|Bacteria,1NE6K@1224|Proteobacteria,43562@68525|delta/epsilon subdivisions,2WZH2@28221|Deltaproteobacteria,2Z24U@29|Myxococcales 28221|Deltaproteobacteria P PhoD-like phosphatase - - 3.1.3.1 ko:K01113 ko00790,ko01100,ko02020,map00790,map01100,map02020 M00126 R04620 RC00017 ko00000,ko00001,ko00002,ko01000 - - - PhoD k59_1717976_1 1232410.KI421412_gene172 4.76e-88 270.0 COG0409@1|root,COG0409@2|Bacteria,1MU1F@1224|Proteobacteria,42M6R@68525|delta/epsilon subdivisions,2WJDQ@28221|Deltaproteobacteria,43U45@69541|Desulfuromonadales 28221|Deltaproteobacteria O TIGRFAM hydrogenase expression formation protein HypD hypD - - ko:K04654 - - - - ko00000 - - iAF987.Gmet_0117 HypD k59_756332_1 562743.JH976434_gene1938 2.7e-11 70.5 COG5002@1|root,COG5002@2|Bacteria,1TQ1H@1239|Firmicutes,4HA52@91061|Bacilli 91061|Bacilli T Histidine kinase vicK - 2.7.13.3 ko:K07652 ko02020,map02020 M00459 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,HisKA,PAS,PAS_9 k59_23356_1 314287.GB2207_07198 1.7e-131 391.0 COG0073@1|root,COG0143@1|root,COG0073@2|Bacteria,COG0143@2|Bacteria,1MUBY@1224|Proteobacteria,1RMYM@1236|Gammaproteobacteria,1J4VI@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation metG GO:0003674,GO:0003824,GO:0004812,GO:0004825,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006431,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.10 ko:K01874 ko00450,ko00970,map00450,map00970 M00359,M00360 R03659,R04773 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iEC042_1314.EC042_2346,iECUMN_1333.ECUMN_2446 Anticodon_1,tRNA-synt_1g,tRNA_bind k59_1152612_1 1112212.JH584235_gene2705 3.13e-06 47.8 COG2241@1|root,COG2242@1|root,COG2241@2|Bacteria,COG2242@2|Bacteria,1MVJX@1224|Proteobacteria,2TRR5@28211|Alphaproteobacteria,2K05J@204457|Sphingomonadales 204457|Sphingomonadales H Tetrapyrrole (Corrin/Porphyrin) Methylases cobL - 2.1.1.132 ko:K00595 ko00860,ko01100,map00860,map01100 - R05149 RC00003,RC01279 ko00000,ko00001,ko01000 - - - Methyltransf_4,PCMT,TP_methylase k59_1152612_2 768066.HELO_1837 2.69e-21 90.1 COG2099@1|root,COG2099@2|Bacteria,1MW48@1224|Proteobacteria,1S0P4@1236|Gammaproteobacteria,1XJTJ@135619|Oceanospirillales 135619|Oceanospirillales H precorrin-6x reductase cobK - 1.3.1.106,1.3.1.54 ko:K05895 ko00860,ko01100,map00860,map01100 - R05150,R05812 RC01280 ko00000,ko00001,ko01000 - - - CbiJ k59_871481_1 366602.Caul_1757 6.02e-20 85.9 COG3717@1|root,COG3717@2|Bacteria,1MU9D@1224|Proteobacteria,2TSU5@28211|Alphaproteobacteria,2KHY1@204458|Caulobacterales 204458|Caulobacterales G Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate kduI - 5.3.1.17 ko:K01815 ko00040,map00040 - R04383 RC00541 ko00000,ko00001,ko01000 - - - KduI k59_871481_2 633149.Bresu_3167 1.61e-100 300.0 COG1028@1|root,COG1028@2|Bacteria,1MWB6@1224|Proteobacteria,2TUKJ@28211|Alphaproteobacteria,2KFD7@204458|Caulobacterales 204458|Caulobacterales IQ PFAM short-chain dehydrogenase reductase SDR kduD - 1.1.1.127 ko:K00065 ko00040,map00040 - R01542 RC00089 ko00000,ko00001,ko01000 - - - adh_short_C2 k59_981603_1 1163617.SCD_n00299 3.9e-85 275.0 COG0058@1|root,COG0058@2|Bacteria,1MW4J@1224|Proteobacteria,2VJIJ@28216|Betaproteobacteria 28216|Betaproteobacteria G Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties glgP - 2.4.1.1 ko:K00688 ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931 - R02111 - ko00000,ko00001,ko01000 - GT35 - Phosphorylase k59_1605223_1 1313172.YM304_16460 5.41e-08 55.1 COG3386@1|root,COG3386@2|Bacteria 2|Bacteria G gluconolactonase activity - - 3.1.1.17 ko:K01053 ko00030,ko00053,ko00930,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,map00030,map00053,map00930,map01100,map01110,map01120,map01130,map01200,map01220 M00129 R01519,R02933,R03751 RC00537,RC00983 ko00000,ko00001,ko00002,ko01000,ko04147 - - - SGL k59_1605223_2 477184.KYC_12148 1.54e-77 239.0 COG2084@1|root,COG2084@2|Bacteria,1MV48@1224|Proteobacteria,2VPIY@28216|Betaproteobacteria 28216|Betaproteobacteria I dehydrogenase - - - - - - - - - - - - NAD_binding_11,NAD_binding_2 k59_529586_1 436308.Nmar_1700 2.51e-19 85.5 COG1527@1|root,arCOG02459@2157|Archaea,41T18@651137|Thaumarchaeota 651137|Thaumarchaeota C ATP synthase (C/AC39) subunit - - - ko:K02119 ko00190,ko01100,map00190,map01100 M00159 - - ko00000,ko00001,ko00002 3.A.2.2,3.A.2.3 - - vATP-synt_AC39 k59_80706_1 1122137.AQXF01000003_gene2328 3.26e-57 186.0 COG0354@1|root,COG0354@2|Bacteria,1N852@1224|Proteobacteria,2TR8J@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Belongs to the GcvT family ygfZ - - ko:K06980,ko:K22073 - - - - ko00000,ko01000,ko03016,ko03029 - - - GCV_T,GCV_T_C k59_23382_1 1144275.COCOR_02207 3.48e-102 315.0 COG2256@1|root,COG2256@2|Bacteria,1MUVS@1224|Proteobacteria,42M9X@68525|delta/epsilon subdivisions,2WJ7E@28221|Deltaproteobacteria,2YU66@29|Myxococcales 28221|Deltaproteobacteria L AAA C-terminal domain rarA - - ko:K07478 - - - - ko00000 - - - AAA,AAA_assoc_2,MgsA_C,RuvB_N k59_587859_1 156978.CIMIT_02405 1.03e-46 171.0 COG2352@1|root,COG2352@2|Bacteria,2GKDB@201174|Actinobacteria,22K4K@1653|Corynebacteriaceae 201174|Actinobacteria H Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle ppc GO:0003674,GO:0003824,GO:0004611,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008964,GO:0016829,GO:0016830,GO:0016831,GO:0044424,GO:0044444,GO:0044464 4.1.1.31 ko:K01595 ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200 M00168,M00170,M00171,M00172,M00173,M00346,M00374 R00345 RC02741 ko00000,ko00001,ko00002,ko01000 - - - PEPcase k59_1379572_1 1415778.JQMM01000001_gene705 1.27e-69 233.0 COG0744@1|root,COG0744@2|Bacteria,1QTST@1224|Proteobacteria,1RNHV@1236|Gammaproteobacteria,1J4N3@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits) mrcB - 2.4.1.129,3.4.16.4 ko:K05365 ko00550,map00550 - R04519 RC00005,RC00049 ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 - Transgly,Transpeptidase,UB2H k59_1549060_1 1449076.JOOE01000002_gene955 3.94e-37 135.0 COG1304@1|root,COG1304@2|Bacteria,1MUEZ@1224|Proteobacteria,2TQNW@28211|Alphaproteobacteria,2K18M@204457|Sphingomonadales 204457|Sphingomonadales C Dehydrogenase lldD - 1.1.2.3 ko:K00101 ko00620,ko01100,map00620,map01100 - R00196 RC00044 ko00000,ko00001,ko01000 - - - FMN_dh k59_1549060_2 1121949.AQXT01000002_gene2454 0.000107 48.1 COG1846@1|root,COG1846@2|Bacteria,1N7G0@1224|Proteobacteria,2UA2S@28211|Alphaproteobacteria,43ZVN@69657|Hyphomonadaceae 28211|Alphaproteobacteria K helix_turn_helix multiple antibiotic resistance protein - - - - - - - - - - - - MarR,MarR_2 k59_1095581_1 83406.HDN1F_34520 4.05e-08 58.9 COG0558@1|root,COG0558@2|Bacteria,1RCZ7@1224|Proteobacteria,1S465@1236|Gammaproteobacteria,1J656@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria I Belongs to the CDP-alcohol phosphatidyltransferase class-I family pgsA GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006629,GO:0006644,GO:0006650,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008444,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016020,GO:0016021,GO:0016740,GO:0016772,GO:0016780,GO:0017169,GO:0019637,GO:0031224,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044425,GO:0044464,GO:0045017,GO:0046474,GO:0046486,GO:0071704,GO:0071944,GO:0090407,GO:1901576 2.7.8.41,2.7.8.5 ko:K00995,ko:K08744 ko00564,ko01100,map00564,map01100 - R01801,R02030 RC00002,RC00017,RC02795 ko00000,ko00001,ko01000 - - iAF1260.b1912,iAPECO1_1312.APECO1_954,iB21_1397.B21_01866,iBWG_1329.BWG_1721,iE2348C_1286.E2348C_2030,iEC042_1314.EC042_2073,iEC55989_1330.EC55989_2132,iECABU_c1320.ECABU_c21710,iECBD_1354.ECBD_1731,iECB_1328.ECB_01877,iECDH10B_1368.ECDH10B_2053,iECDH1ME8569_1439.ECDH1ME8569_1852,iECD_1391.ECD_01877,iECED1_1282.ECED1_2177,iECH74115_1262.ECH74115_2684,iECIAI1_1343.ECIAI1_1996,iECIAI39_1322.ECIAI39_1143,iECNA114_1301.ECNA114_2003,iECO103_1326.ECO103_2168,iECO111_1330.ECO111_2492,iECO26_1355.ECO26_2804,iECOK1_1307.ECOK1_2029,iECP_1309.ECP_1852,iECS88_1305.ECS88_1966,iECSF_1327.ECSF_1764,iECSP_1301.ECSP_2516,iECUMN_1333.ECUMN_2204,iECs_1301.ECs2650,iETEC_1333.ETEC_2020,iEcDH1_1363.EcDH1_1734,iEcE24377_1341.EcE24377A_2145,iEcHS_1320.EcHS_A2010,iEcSMS35_1347.EcSMS35_1271,iEcolC_1368.EcolC_1727,iG2583_1286.G2583_2363,iJO1366.b1912,iJR904.b1912,iLF82_1304.LF82_1635,iNRG857_1313.NRG857_09550,iSDY_1059.SDY_1106,iSSON_1240.SSON_1206,iSbBS512_1146.SbBS512_E1039,iUMN146_1321.UM146_07620,iUMNK88_1353.UMNK88_2386,iUTI89_1310.UTI89_C2113,iY75_1357.Y75_RS10025,iYL1228.KPN_02410,iZ_1308.Z3000,ic_1306.c2325 CDP-OH_P_transf k59_1718016_1 4932.YHR214C-B 9.64e-120 379.0 COG2801@1|root,KOG0017@2759|Eukaryota,39YUU@33154|Opisthokonta,3P1DN@4751|Fungi,3QRDY@4890|Ascomycota,3RSWN@4891|Saccharomycetes,3RZQ4@4893|Saccharomycetaceae 4751|Fungi L polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN) - GO:0000943,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0003887,GO:0003964,GO:0004518,GO:0004540,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0006139,GO:0006259,GO:0006278,GO:0006508,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0019538,GO:0032196,GO:0032197,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044422,GO:0044424,GO:0044428,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071897,GO:0090304,GO:0090305,GO:0090501,GO:0097159,GO:0140096,GO:0140097,GO:0140098,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901576 - - - - - - - - - - RVT_2,TYA,gag_pre-integrs,rve k59_1379584_2 765420.OSCT_2999 3.55e-12 69.3 COG0492@1|root,COG0492@2|Bacteria 2|Bacteria C ferredoxin-NADP+ reductase activity - - - - - - - - - - - - FAD_binding_2,FAD_oxidored,Pyr_redox_2,Thioredoxin_3,cNMP_binding k59_1095592_1 1305732.JAGG01000001_gene327 6.59e-48 171.0 COG0471@1|root,COG0471@2|Bacteria,2GVHZ@201174|Actinobacteria,4FQPQ@85023|Microbacteriaceae 201174|Actinobacteria P Sodium:sulfate symporter transmembrane region sdcS - - ko:K03319,ko:K14445 - - - - ko00000,ko02000 2.A.47,2.A.47.1 - - Na_sulph_symp k59_1718031_1 1121904.ARBP01000011_gene1571 4.5e-26 110.0 COG3507@1|root,COG3507@2|Bacteria 2|Bacteria G Belongs to the glycosyl hydrolase 43 family - - 3.2.1.8,4.2.2.10,4.2.2.2 ko:K01181,ko:K19551 ko00040,map00040 - R02361 RC00049,RC00705 ko00000,ko00001,ko01000 - - - CBM_6,CHB_HEX_C_1,Glyco_hydro_11,Laminin_G_3,Pectate_lyase,Polysacc_deac_1,RicinB_lectin_2 k59_926106_2 1121035.AUCH01000005_gene112 7.3e-44 150.0 COG1392@1|root,COG1392@2|Bacteria,1NDTG@1224|Proteobacteria,2VJ5F@28216|Betaproteobacteria,2KVDV@206389|Rhodocyclales 206389|Rhodocyclales P Protein of unknown function DUF47 - - - ko:K07220 - - - - ko00000 - - - PhoU_div k59_701936_1 909663.KI867150_gene1863 4.56e-15 79.7 COG0370@1|root,COG0370@2|Bacteria,1MUZC@1224|Proteobacteria,42Y5V@68525|delta/epsilon subdivisions,2WU3F@28221|Deltaproteobacteria,2MRCS@213462|Syntrophobacterales 28221|Deltaproteobacteria P FeoA - - - ko:K04759 - - - - ko00000,ko02000 9.A.8.1 - - FeoA,FeoB_C,FeoB_N,Gate k59_1210370_1 264732.Moth_1811 1.05e-66 228.0 COG3280@1|root,COG3280@2|Bacteria,1UERK@1239|Firmicutes,25JR7@186801|Clostridia,42HXY@68295|Thermoanaerobacterales 186801|Clostridia G Alpha amylase, catalytic domain - - 5.4.99.15 ko:K06044 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R01824,R09995 - ko00000,ko00001,ko00002,ko01000 - GH13 - Alpha-amylase k59_1549997_1 436308.Nmar_0546 1.8e-22 95.9 COG0436@1|root,COG1605@1|root,arCOG01130@2157|Archaea,arCOG02098@2157|Archaea,41SBV@651137|Thaumarchaeota 651137|Thaumarchaeota E Chorismate mutase type II - - 2.6.1.1 ko:K00812 ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230 - R00355,R00694,R00734,R00896,R02433,R02619,R05052 RC00006 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_1_2,CM_2 k59_1549997_2 436308.Nmar_0547 3.84e-226 627.0 COG0082@1|root,arCOG04133@2157|Archaea,41SC3@651137|Thaumarchaeota 651137|Thaumarchaeota E Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system aroC - 4.2.3.5 ko:K01736 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R01714 RC00586 ko00000,ko00001,ko00002,ko01000 - - - Chorismate_synt k59_1606167_1 497321.C664_00840 2.29e-117 361.0 COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,2VHSK@28216|Betaproteobacteria,2KV96@206389|Rhodocyclales 206389|Rhodocyclales KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance relA - 2.7.6.5 ko:K00951 ko00230,map00230 - R00429 RC00002,RC00078 ko00000,ko00001,ko01000 - - - ACT_4,HD_4,RelA_SpoT,TGS k59_756959_1 1278073.MYSTI_07874 5.16e-52 191.0 COG3391@1|root,COG3391@2|Bacteria,1R66T@1224|Proteobacteria,439FZ@68525|delta/epsilon subdivisions,2X4RS@28221|Deltaproteobacteria,2YZGC@29|Myxococcales 28221|Deltaproteobacteria G 6-phosphogluconolactonase activity - - - - - - - - - - - - - k59_307212_1 1144305.PMI02_00423 3.2e-22 95.5 COG0243@1|root,COG0243@2|Bacteria,1NS3T@1224|Proteobacteria,2TQYD@28211|Alphaproteobacteria,2K1FR@204457|Sphingomonadales 204457|Sphingomonadales C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - - - - - - - - - - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding k59_307212_2 1144307.PMI04_00626 3.7e-56 186.0 COG0438@1|root,COG0438@2|Bacteria 2|Bacteria M transferase activity, transferring glycosyl groups - - - - - - - - - - - - O-antigen_lig,Sulfotransfer_3 k59_1042159_1 518766.Rmar_0542 4.33e-54 193.0 COG3127@1|root,COG3127@2|Bacteria,4NF16@976|Bacteroidetes,1FIZR@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes Q MacB-like periplasmic core domain - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_1380459_1 391603.FBALC1_08698 1.78e-84 278.0 COG3209@1|root,COG3291@1|root,COG3209@2|Bacteria,COG3291@2|Bacteria,4NDZC@976|Bacteroidetes,1HY1V@117743|Flavobacteriia 976|Bacteroidetes DZ adhesin AidA-related sprB - - - - - - - - - - - CHU_C,DUF11,SprB k59_137179_1 425104.Ssed_3889 1.49e-52 179.0 COG3203@1|root,COG3203@2|Bacteria,1R5I5@1224|Proteobacteria,1RM86@1236|Gammaproteobacteria,2Q904@267890|Shewanellaceae 1236|Gammaproteobacteria M PFAM phosphate-selective porin O and P - - - - - - - - - - - - Porin_4,Porin_O_P k59_1265127_1 448385.sce2406 1.16e-17 81.6 COG0724@1|root,COG0724@2|Bacteria,1N6VR@1224|Proteobacteria 1224|Proteobacteria S PFAM RNP-1 like RNA-binding protein rbpA - - - - - - - - - - - RRM_1 k59_249529_1 679937.Bcop_1499 1.56e-21 95.9 COG0072@1|root,COG0073@1|root,COG0072@2|Bacteria,COG0073@2|Bacteria,4NF5B@976|Bacteroidetes,2FNBF@200643|Bacteroidia,4AM0P@815|Bacteroidaceae 976|Bacteroidetes J Psort location Cytoplasmic, score pheT GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016070,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494 6.1.1.20 ko:K01890 ko00970,map00970 M00359,M00360 R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - B3_4,B5,FDX-ACB,tRNA_bind k59_249529_2 617140.AJZE01000069_gene4133 4.79e-55 182.0 COG0016@1|root,COG0016@2|Bacteria,1MVD7@1224|Proteobacteria,1RN22@1236|Gammaproteobacteria,1XTCW@135623|Vibrionales 135623|Vibrionales J Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily pheS GO:0003674,GO:0003824,GO:0004812,GO:0004826,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.20 ko:K01889 ko00970,map00970 M00359,M00360 R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Phe_tRNA-synt_N,tRNA-synt_2d k59_813801_1 1245469.S58_25880 7.92e-70 233.0 COG1523@1|root,COG1523@2|Bacteria,1MU19@1224|Proteobacteria,2TRVS@28211|Alphaproteobacteria,3JR1B@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria G Belongs to the glycosyl hydrolase 13 family glgX - 3.2.1.196,3.2.1.68 ko:K01214,ko:K02438 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R02111,R09995,R11261 - ko00000,ko00001,ko00002,ko01000 - CBM48,GH13 - Alpha-amylase,CBM_48 k59_1661953_1 1313172.YM304_25320 5.47e-37 135.0 COG4630@1|root,COG4630@2|Bacteria,2I33J@201174|Actinobacteria 201174|Actinobacteria F Xanthine dehydrogenase iron-sulfur cluster and FAD-binding subunit A xdhA - 1.17.1.4 ko:K13481 ko00230,ko01100,ko01120,map00230,map01100,map01120 M00546 R01768,R02103 RC00143 ko00000,ko00001,ko00002,ko01000 - - - CO_deh_flav_C,FAD_binding_5,Fer2,Fer2_2 k59_1661953_2 1268072.PSAB_06795 1.41e-55 180.0 COG2080@1|root,COG2080@2|Bacteria,1V6HE@1239|Firmicutes,4HINQ@91061|Bacilli,26WWD@186822|Paenibacillaceae 91061|Bacilli C Dehydrogenase - - 1.17.1.4,1.2.5.3 ko:K00087,ko:K03518 ko00230,ko01100,ko01120,map00230,map01100,map01120 M00546 R01768,R02103,R11168 RC00143,RC02800 ko00000,ko00001,ko00002,ko01000 - - iYO844.BSU32470 Fer2,Fer2_2 k59_1661953_3 1120936.KB907216_gene3810 3.52e-57 199.0 COG1529@1|root,COG1529@2|Bacteria,2GIVI@201174|Actinobacteria,4EHTQ@85012|Streptosporangiales 201174|Actinobacteria C Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain - - - - - - - - - - - - Ald_Xan_dh_C,Ald_Xan_dh_C2 k59_1493729_1 652103.Rpdx1_3508 2.63e-67 221.0 COG0028@1|root,COG0028@2|Bacteria,1MX6Q@1224|Proteobacteria,2TR5N@28211|Alphaproteobacteria,3JV65@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria EH acetolactate synthase large subunit - - 2.2.1.6,4.1.1.7 ko:K01576,ko:K01652 ko00290,ko00627,ko00650,ko00660,ko00770,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00290,map00627,map00650,map00660,map00770,map01100,map01110,map01120,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R01764,R02672,R03050,R04672,R04673,R08648 RC00027,RC00106,RC00595,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_1493747_2 349163.Acry_1099 2.3e-83 257.0 COG0583@1|root,COG0583@2|Bacteria,1R4NT@1224|Proteobacteria,2U1ZF@28211|Alphaproteobacteria,2JZHT@204441|Rhodospirillales 204441|Rhodospirillales K LysR substrate binding domain - - - - - - - - - - - - HTH_1,LysR_substrate k59_24357_1 1122137.AQXF01000001_gene3027 2.61e-29 111.0 COG0220@1|root,COG0220@2|Bacteria,1MUWJ@1224|Proteobacteria,2TUU9@28211|Alphaproteobacteria 28211|Alphaproteobacteria J catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA trmB GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008176,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0034708,GO:0036265,GO:0043170,GO:0043412,GO:0043414,GO:0043527,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0106004,GO:0140098,GO:0140101,GO:1901360,GO:1902494,GO:1990234 2.1.1.33 ko:K03439 - - - - ko00000,ko01000,ko03016 - - - Methyltransf_4 k59_24357_2 1193729.A1OE_253 1.19e-07 55.1 COG0815@1|root,COG0815@2|Bacteria,1MUBU@1224|Proteobacteria,2TQRC@28211|Alphaproteobacteria,2JQ0M@204441|Rhodospirillales 204441|Rhodospirillales M Transfers the fatty acyl group on membrane lipoproteins lnt - - ko:K03820 - - - - ko00000,ko01000 - GT2 - CN_hydrolase k59_1153421_1 1122194.AUHU01000010_gene3108 4.38e-137 400.0 COG2211@1|root,COG2211@2|Bacteria,1MVUM@1224|Proteobacteria,1RP5J@1236|Gammaproteobacteria,464K4@72275|Alteromonadaceae 1236|Gammaproteobacteria G COG2211 Na melibiose symporter and related transporters - - - ko:K03292 - - - - ko00000 2.A.2 - - MFS_2 k59_644191_2 1122132.AQYH01000003_gene3170 5.02e-29 119.0 COG2942@1|root,COG2942@2|Bacteria,1N42A@1224|Proteobacteria,2TW1E@28211|Alphaproteobacteria,4BB2D@82115|Rhizobiaceae 28211|Alphaproteobacteria G mannose-6-phosphate isomerase pmi - 5.3.1.8 ko:K01809 ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130 M00114 R01819 RC00376 ko00000,ko00001,ko00002,ko01000 - - - GlcNAc_2-epim k59_1550066_1 113395.AXAI01000001_gene3049 2.03e-06 50.4 COG0845@1|root,COG0845@2|Bacteria,1MW65@1224|Proteobacteria,2TSB6@28211|Alphaproteobacteria,3JWP5@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria M Biotin-lipoyl like - - - ko:K07799,ko:K18990 ko02020,map02020 M00648,M00720 - - ko00000,ko00001,ko00002,ko02000 2.A.6.2.30,8.A.1 - - Biotin_lipoyl_2,HlyD_3,HlyD_D23 k59_1550066_2 177437.HRM2_47440 2.99e-60 207.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MQ0@68525|delta/epsilon subdivisions,2WISW@28221|Deltaproteobacteria,2MIUG@213118|Desulfobacterales 28221|Deltaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_307269_1 1088721.NSU_0401 2.11e-111 340.0 COG2225@1|root,COG2225@2|Bacteria,1MVEV@1224|Proteobacteria,2TS9R@28211|Alphaproteobacteria,2K0KC@204457|Sphingomonadales 204457|Sphingomonadales C Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA glcB - 2.3.3.9 ko:K01638 ko00620,ko00630,ko01100,ko01110,ko01120,ko01200,map00620,map00630,map01100,map01110,map01120,map01200 M00012 R00472 RC00004,RC00308,RC02747 ko00000,ko00001,ko00002,ko01000 - - - Malate_synthase k59_363991_1 13690.CP98_00604 3e-70 219.0 COG0599@1|root,COG0599@2|Bacteria 2|Bacteria S peroxiredoxin activity rnhA - 3.1.26.4,4.1.1.44 ko:K01607,ko:K03469 ko00362,ko01100,ko01120,ko01220,ko03030,map00362,map01100,map01120,map01220,map03030 - R03470 RC00938 ko00000,ko00001,ko01000,ko03032 - - - CMD k59_81647_1 1459636.NTE_00306 3.11e-74 239.0 COG1215@1|root,arCOG01389@2157|Archaea,41TAH@651137|Thaumarchaeota 2157|Archaea M PFAM Glycosyl transferase family 2 - - 2.4.1.212 ko:K00752 - - - - ko00000,ko01000,ko01003,ko02000 4.D.1.1.10,4.D.1.1.4,4.D.1.1.5 GT2 - Glycos_transf_2 k59_307282_1 436308.Nmar_0686 5.23e-76 244.0 COG0018@1|root,arCOG00487@2157|Archaea,41SAI@651137|Thaumarchaeota 651137|Thaumarchaeota J Belongs to the class-I aminoacyl-tRNA synthetase family argS - 6.1.1.19 ko:K01887 ko00970,map00970 M00359,M00360 R03646 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d k59_530230_1 876044.IMCC3088_2843 2.93e-47 169.0 COG0484@1|root,COG0484@2|Bacteria,1MXM9@1224|Proteobacteria,1T3FX@1236|Gammaproteobacteria 1236|Gammaproteobacteria C heat shock protein binding - - - - - - - - - - - - Cytochrome_C7 k59_982340_1 316407.1651616 3.28e-110 333.0 COG3850@1|root,COG3850@2|Bacteria,1MWZT@1224|Proteobacteria,1RNPP@1236|Gammaproteobacteria,3XMF0@561|Escherichia 1236|Gammaproteobacteria T Acts as a sensor for nitrate nitrite and transduces signal of nitrate availability to the NarL protein and of both nitrate nitrite to the NarP protein. NarX probably activates NarL and NarP by phosphorylation in the presence of nitrate. NarX also plays a negative role in controlling NarL activity, probably through dephosphorylation in the absence of nitrate narX GO:0000155,GO:0000160,GO:0001101,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0004721,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009987,GO:0010035,GO:0010167,GO:0016020,GO:0016301,GO:0016310,GO:0016311,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0016787,GO:0016788,GO:0016791,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0023014,GO:0023052,GO:0033554,GO:0035556,GO:0036211,GO:0042221,GO:0042578,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0046777,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0070887,GO:0071229,GO:0071241,GO:0071249,GO:0071250,GO:0071704,GO:0071944,GO:0080033,GO:0140096,GO:1901564,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902170 2.7.13.3 ko:K07673,ko:K07674 ko02020,map02020 M00471,M00472 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,HisKA_3,PilJ k59_419173_1 1122137.AQXF01000001_gene3121 1.02e-129 372.0 COG0755@1|root,COG0755@2|Bacteria,1MU61@1224|Proteobacteria,2TSW8@28211|Alphaproteobacteria 28211|Alphaproteobacteria O Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes ccmC GO:0001539,GO:0002048,GO:0002049,GO:0003674,GO:0003824,GO:0004096,GO:0004601,GO:0005575,GO:0005623,GO:0005886,GO:0006518,GO:0006629,GO:0006643,GO:0006664,GO:0006807,GO:0006810,GO:0006928,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009237,GO:0009247,GO:0009636,GO:0009987,GO:0015886,GO:0016020,GO:0016209,GO:0016491,GO:0016684,GO:0019184,GO:0019290,GO:0019748,GO:0034641,GO:0040011,GO:0042221,GO:0043043,GO:0043107,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044271,GO:0044464,GO:0044550,GO:0046467,GO:0048870,GO:0050896,GO:0051179,GO:0051181,GO:0051186,GO:0051188,GO:0051234,GO:0051674,GO:0051716,GO:0055114,GO:0070887,GO:0071702,GO:0071704,GO:0071705,GO:0071944,GO:0071973,GO:0071975,GO:0071977,GO:0071978,GO:0097237,GO:0097588,GO:0098754,GO:0098869,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576,GO:1901678,GO:1903509,GO:1990748 - ko:K02195 ko02010,map02010 M00259 - - ko00000,ko00001,ko00002,ko02000 3.A.1.107 - - Cytochrom_C_asm k59_419173_2 323850.Shew_0187 2.38e-08 52.0 COG3114@1|root,COG3114@2|Bacteria,1NGBM@1224|Proteobacteria,1SGGH@1236|Gammaproteobacteria,2QCUF@267890|Shewanellaceae 1236|Gammaproteobacteria U Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes ccmD GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0009898,GO:0015886,GO:0016020,GO:0031224,GO:0031226,GO:0031235,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051181,GO:0051234,GO:0071702,GO:0071705,GO:0071944,GO:0098552,GO:0098562,GO:1901678 - ko:K02196 ko02010,map02010 - - - ko00000,ko00001,ko02000 3.A.1.107 - iB21_1397.B21_02084,iBWG_1329.BWG_1971,iE2348C_1286.E2348C_2342,iEC042_1314.EC042_2439,iEC55989_1330.EC55989_2451,iECABU_c1320.ECABU_c25320,iECBD_1354.ECBD_1462,iECB_1328.ECB_02125,iECDH10B_1368.ECDH10B_2355,iECDH1ME8569_1439.ECDH1ME8569_2133,iECD_1391.ECD_02125,iECED1_1282.ECED1_2663,iECH74115_1262.ECH74115_3335,iECIAI1_1343.ECIAI1_2280,iECIAI39_1322.ECIAI39_2336,iECNA114_1301.ECNA114_2290,iECO103_1326.ECO103_2673,iECO111_1330.ECO111_2934,iECO26_1355.ECO26_3124,iECOK1_1307.ECOK1_2432,iECP_1309.ECP_2238,iECS88_1305.ECS88_2345,iECSE_1348.ECSE_2466,iECSF_1327.ECSF_2079,iECSP_1301.ECSP_3077,iECUMN_1333.ECUMN_2533,iECs_1301.ECs3087,iEKO11_1354.EKO11_1558,iETEC_1333.ETEC_2332,iEcDH1_1363.EcDH1_1461,iEcE24377_1341.EcE24377A_2497,iEcHS_1320.EcHS_A2336,iEcSMS35_1347.EcSMS35_2346,iEcolC_1368.EcolC_1452,iJO1366.b2198,iLF82_1304.LF82_0276,iNRG857_1313.NRG857_11155,iSDY_1059.SDY_0880,iSFV_1184.SFV_2274,iSF_1195.SF2282,iSSON_1240.SSON_2256,iS_1188.S2412,iUMN146_1321.UM146_05815,iUMNK88_1353.UMNK88_2745,iUTI89_1310.UTI89_C2476,iY75_1357.Y75_RS11500,iZ_1308.Z3455,ic_1306.c2735 CcmD k59_419173_3 1122137.AQXF01000001_gene3119 1.75e-26 101.0 COG2332@1|root,COG2332@2|Bacteria,1RHN5@1224|Proteobacteria,2U99J@28211|Alphaproteobacteria 28211|Alphaproteobacteria O Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH ccmE GO:0003674,GO:0003824,GO:0008150,GO:0009987,GO:0016043,GO:0017004,GO:0022607,GO:0034622,GO:0043933,GO:0044085,GO:0065003,GO:0071840 - ko:K02197 - - - - ko00000 - - - CcmE k59_1153450_2 317655.Sala_0867 3.58e-116 342.0 COG1028@1|root,COG1028@2|Bacteria,1R9UK@1224|Proteobacteria,2U35Z@28211|Alphaproteobacteria,2KCN1@204457|Sphingomonadales 204457|Sphingomonadales IQ KR domain - - - - - - - - - - - - adh_short_C2 k59_588830_1 1117647.M5M_15605 1e-156 454.0 COG3119@1|root,COG3119@2|Bacteria,1MUJH@1224|Proteobacteria,1RN2V@1236|Gammaproteobacteria,1J88Q@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P COG3119 Arylsulfatase A and related enzymes - - 3.1.6.1 ko:K01130 ko00140,ko00600,map00140,map00600 - R03980,R04856 RC00128,RC00231 ko00000,ko00001,ko01000 - - - Sulfatase,Sulfatase_C k59_1493791_2 105559.Nwat_1157 1.81e-98 296.0 COG0372@1|root,COG0372@2|Bacteria,1RCFK@1224|Proteobacteria,1S2C0@1236|Gammaproteobacteria,1X11A@135613|Chromatiales 135613|Chromatiales C Belongs to the citrate synthase family - - - - - - - - - - - - Citrate_synt k59_1662000_2 1210884.HG799464_gene10885 1.82e-51 180.0 COG1233@1|root,COG1233@2|Bacteria,2IX17@203682|Planctomycetes 203682|Planctomycetes Q FAD dependent oxidoreductase - - - - - - - - - - - - Amino_oxidase k59_872501_1 314285.KT71_15009 6.58e-108 343.0 COG1197@1|root,COG1197@2|Bacteria,1MUXG@1224|Proteobacteria,1RNCU@1236|Gammaproteobacteria,1J8SY@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site mfd GO:0000715,GO:0000716,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006283,GO:0006289,GO:0006355,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008094,GO:0008150,GO:0008152,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0015616,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019219,GO:0019222,GO:0019899,GO:0031323,GO:0031326,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0043175,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0051276,GO:0051716,GO:0060255,GO:0065007,GO:0070063,GO:0071704,GO:0071840,GO:0080090,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1903506,GO:2000112,GO:2001141 - ko:K03723 ko03420,map03420 - - - ko00000,ko00001,ko01000,ko03400 - - - CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF k59_588833_1 436308.Nmar_1766 3.39e-79 254.0 arCOG02362@1|root,arCOG07810@1|root,arCOG02362@2157|Archaea,arCOG07810@2157|Archaea,41T0S@651137|Thaumarchaeota 651137|Thaumarchaeota N Adenylate guanylate cyclase with integral membrane sensor - - - - - - - - - - - - Guanylate_cyc,HAMP k59_530240_1 316407.1651412 6.85e-105 337.0 COG1178@1|root,COG1674@1|root,COG1178@2|Bacteria,COG1674@2|Bacteria,1MVPI@1224|Proteobacteria,1RM9A@1236|Gammaproteobacteria,3XN27@561|Escherichia 1236|Gammaproteobacteria D Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region. Translocation stops specifically at Xer-dif sites, where FtsK interacts with the Xer recombinase, allowing activation of chromosome unlinking by recombination. FtsK orienting polar sequences (KOPS) guide the direction of DNA translocation. FtsK can remove proteins from DNA as it translocates, but translocation stops specifically at XerCD-dif site, thereby preventing removal of XerC and XerD from dif ftsK GO:0000920,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006355,GO:0006950,GO:0006970,GO:0007059,GO:0008094,GO:0008150,GO:0009628,GO:0009651,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0015616,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019219,GO:0019222,GO:0031224,GO:0031226,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0033676,GO:0042221,GO:0042623,GO:0042802,GO:0043085,GO:0043565,GO:0044093,GO:0044425,GO:0044459,GO:0044464,GO:0045893,GO:0045935,GO:0046677,GO:0048518,GO:0048522,GO:0050789,GO:0050790,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051301,GO:0051716,GO:0060255,GO:0065007,GO:0065009,GO:0070887,GO:0071236,GO:0071944,GO:0080090,GO:0097159,GO:0140097,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141 - ko:K03466 - - - - ko00000,ko03036 3.A.12 - - FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma k59_1042255_1 1265313.HRUBRA_02355 1.08e-59 197.0 COG0845@1|root,COG0845@2|Bacteria,1MUI8@1224|Proteobacteria,1RNK4@1236|Gammaproteobacteria,1J4TZ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M COG0845 Membrane-fusion protein - - - ko:K11003,ko:K12542 ko03070,ko05133,map03070,map05133 M00325,M00330,M00575 - - ko00000,ko00001,ko00002,ko02000,ko02044 3.A.1.109.4,8.A.1,8.A.1.3.1,8.A.1.3.2 - - Biotin_lipoyl_2,HlyD,HlyD_3 k59_1726524_2 521674.Plim_2355 2.99e-13 69.7 COG0589@1|root,COG0589@2|Bacteria,2J0XB@203682|Planctomycetes 203682|Planctomycetes T Universal stress protein - - - - - - - - - - - - Usp k59_258184_1 1122201.AUAZ01000006_gene3891 2.74e-71 223.0 COG2755@1|root,COG2755@2|Bacteria,1RCXZ@1224|Proteobacteria,1S3QU@1236|Gammaproteobacteria,466ZZ@72275|Alteromonadaceae 1236|Gammaproteobacteria E COG2755 Lysophospholipase L1 and related esterases tesA GO:0003674,GO:0003824,GO:0004620,GO:0004622,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0016289,GO:0016290,GO:0016298,GO:0016787,GO:0016788,GO:0016790,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0042802,GO:0043170,GO:0044238,GO:0044464,GO:0047617,GO:0052689,GO:0071704,GO:0140096,GO:1901564 3.1.1.5 ko:K10804 ko01040,map01040 - - - ko00000,ko00001,ko01000,ko01004 - - iECED1_1282.ECED1_0521,iLF82_1304.LF82_2242,iNRG857_1313.NRG857_02365 Lipase_GDSL_2 k59_881257_1 1163408.UU9_00255 2.55e-63 225.0 COG2373@1|root,COG2373@2|Bacteria,1MV7J@1224|Proteobacteria,1RNRY@1236|Gammaproteobacteria,1X4ST@135614|Xanthomonadales 135614|Xanthomonadales S Large extracellular alpha-helical protein - - - ko:K06894 - - - - ko00000 - - - A2M,A2M_N,A2M_N_2,MG1 k59_1102983_1 436308.Nmar_1735 1.35e-27 108.0 arCOG03788@1|root,arCOG03788@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - LEA_2 k59_988796_1 1122137.AQXF01000001_gene3245 4.97e-180 508.0 COG1158@1|root,COG1158@2|Bacteria,1MUCF@1224|Proteobacteria,2TRB4@28211|Alphaproteobacteria 28211|Alphaproteobacteria K Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template rho - - ko:K03628 ko03018,map03018 - - - ko00000,ko00001,ko03019,ko03021 - - - ATP-synt_ab,Rho_N,Rho_RNA_bind k59_711568_2 203122.Sde_0758 6.94e-37 131.0 COG2941@1|root,COG2941@2|Bacteria,1RAA1@1224|Proteobacteria,1RPMV@1236|Gammaproteobacteria,466J9@72275|Alteromonadaceae 1236|Gammaproteobacteria H Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol coq7 - - ko:K06134 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00128 R04984,R08775 RC01254 ko00000,ko00001,ko00002,ko01000 - - - COQ7 k59_1779507_1 1229909.NSED_03925 1.29e-98 301.0 COG5427@1|root,arCOG00563@2157|Archaea 2157|Archaea S membrane - - - - - - - - - - - - PMT_2 k59_598427_1 1229909.NSED_09410 9.56e-28 110.0 COG0520@1|root,arCOG00065@2157|Archaea,41SYH@651137|Thaumarchaeota 651137|Thaumarchaeota E Aminotransferase class-V - - 2.8.1.7,4.4.1.16 ko:K11717 ko00450,ko01100,map00450,map01100 - R03599,R11528 RC00961,RC01789,RC02313 ko00000,ko00001,ko01000 - - - Aminotran_5 k59_598427_2 436308.Nmar_1762 3.84e-45 147.0 COG1522@1|root,arCOG01117@2157|Archaea,41T58@651137|Thaumarchaeota 651137|Thaumarchaeota K Lrp/AsnC ligand binding domain - - - - - - - - - - - - AsnC_trans_reg k59_201281_1 566466.NOR53_937 1.03e-77 243.0 COG4948@1|root,COG4948@2|Bacteria,1MW76@1224|Proteobacteria,1RMKS@1236|Gammaproteobacteria,1J8MR@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Belongs to the mandelate racemase muconate lactonizing enzyme family ycjG GO:0003674,GO:0003824,GO:0016853,GO:0016854,GO:0016855 5.1.1.20,5.5.1.1 ko:K01856,ko:K19802 ko00361,ko00362,ko00364,ko00623,ko01100,ko01120,ko01220,map00361,map00362,map00364,map00623,map01100,map01120,map01220 M00568 R05300,R05390,R06989,R08116,R09229,R10938 RC00903,RC01038,RC01108,RC01321,RC01356,RC03309 ko00000,ko00001,ko00002,ko01000 - - iEC042_1314.EC042_1441,iECUMN_1333.ECUMN_1620 MR_MLE_C,MR_MLE_N k59_1272355_1 338966.Ppro_0827 7.1e-22 94.7 COG0741@1|root,COG0741@2|Bacteria,1MZ4X@1224|Proteobacteria,42TVX@68525|delta/epsilon subdivisions,2WP4F@28221|Deltaproteobacteria,43TTA@69541|Desulfuromonadales 28221|Deltaproteobacteria M PFAM Lytic transglycosylase catalytic - - - ko:K08309 - - - - ko00000,ko01000,ko01011 - GH23 - DUF4124,SLT k59_258949_1 616991.JPOO01000003_gene654 1.57e-26 105.0 COG1321@1|root,COG1918@1|root,COG1321@2|Bacteria,COG1918@2|Bacteria,4NGUP@976|Bacteroidetes,1I7EA@117743|Flavobacteriia 976|Bacteroidetes KP FeoA - - - ko:K03709 - - - - ko00000,ko03000 - - - Fe_dep_repr_C,FeoA k59_258949_2 641524.ADICYQ_2376 6.66e-79 241.0 COG0370@1|root,COG0370@2|Bacteria,4NEII@976|Bacteroidetes,47JEQ@768503|Cytophagia 976|Bacteroidetes P transporter of a GTP-driven Fe(2 ) uptake system - - - - - - - - - - - - FeoA,FeoB_C,FeoB_N,Gate k59_90375_1 927658.AJUM01000034_gene274 1.91e-08 62.0 COG4797@1|root,COG4797@2|Bacteria,4PKQS@976|Bacteroidetes,2FP69@200643|Bacteroidia,3XIJ5@558415|Marinilabiliaceae 976|Bacteroidetes S Motility related/secretion protein sprA - - - - - - - - - - - SprA_N k59_1050955_2 1238190.AMQY01000010_gene2307 3.28e-11 68.2 28H9R@1|root,2Z7MD@2|Bacteria,1MVTR@1224|Proteobacteria,1RMPH@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Psort location Cytoplasmic, score 8.96 yfjQ - - - - - - - - - - - DUF932 k59_821667_2 1385517.N800_11420 4.96e-52 174.0 COG0181@1|root,COG0181@2|Bacteria,1MU56@1224|Proteobacteria,1RMQ8@1236|Gammaproteobacteria,1X4A7@135614|Xanthomonadales 135614|Xanthomonadales H Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps hemC GO:0003674,GO:0003824,GO:0004418,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.61 ko:K01749 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R00084 RC02317 ko00000,ko00001,ko00002,ko01000 - - - Porphobil_deam,Porphobil_deamC k59_989332_1 316407.85675392 2.8e-20 89.0 COG2199@1|root,COG2200@1|root,COG2199@2|Bacteria,COG2200@2|Bacteria,1RGCV@1224|Proteobacteria,1T1U0@1236|Gammaproteobacteria,3XNQ0@561|Escherichia 1236|Gammaproteobacteria T cyclic-guanylate-specific phosphodiesterase activity yfeA GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0008081,GO:0016020,GO:0016787,GO:0016788,GO:0042578,GO:0044464,GO:0071111,GO:0071944 - - - - - - - - - - EAL,GGDEF,MASE1 k59_989332_2 316407.85675391 5.14e-268 733.0 COG3385@1|root,COG3385@2|Bacteria,1RCTP@1224|Proteobacteria,1SGPT@1236|Gammaproteobacteria,3XQ8Y@561|Escherichia 1236|Gammaproteobacteria L transposase - - - - - - - - - - - - DDE_Tnp_1 k59_1161963_1 1411685.U062_00254 9.62e-68 225.0 COG0405@1|root,COG0405@2|Bacteria,1MUV6@1224|Proteobacteria,1RMIT@1236|Gammaproteobacteria,1J5I7@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M COG0405 Gamma-glutamyltransferase ggt GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0006082,GO:0006508,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0008242,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016787,GO:0019538,GO:0019752,GO:0030288,GO:0030313,GO:0031975,GO:0034722,GO:0036374,GO:0042597,GO:0043094,GO:0043102,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0070011,GO:0071704,GO:0097264,GO:0140096,GO:1901564,GO:1901566,GO:1901576 2.3.2.2,3.4.19.13 ko:K00681 ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100 - R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935 RC00064,RC00090,RC00096 ko00000,ko00001,ko01000,ko01002 - - iAPECO1_1312.APECO1_3012,iECOK1_1307.ECOK1_3869,iECS88_1305.ECS88_3844,iECW_1372.ECW_m3706,iEKO11_1354.EKO11_0296,iETEC_1333.ETEC_3693,iUMN146_1321.UM146_17325,iUTI89_1310.UTI89_C3954,iWFL_1372.ECW_m3706 G_glu_transpept k59_1329183_1 1056820.KB900632_gene2193 1.99e-82 268.0 COG0550@1|root,COG0550@2|Bacteria,1MUFZ@1224|Proteobacteria,1RNZ2@1236|Gammaproteobacteria,2PN7V@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria L Bacterial DNA topoisomeraes I ATP-binding domain topA GO:0003674,GO:0003824,GO:0003916,GO:0003917,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006265,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0016853,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051276,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360 5.99.1.2 ko:K03168 - - - - ko00000,ko01000,ko03032,ko03400 - - - Topo_Zn_Ribbon,Topoisom_bac,Toprim,Toprim_C_rpt,zf-C4_Topoisom k59_373679_1 377629.TERTU_0935 1.5e-85 281.0 COG1640@1|root,COG1640@2|Bacteria,1QTVJ@1224|Proteobacteria,1RMJW@1236|Gammaproteobacteria,2PP4B@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria G 4-alpha-glucanotransferase malQ - 2.4.1.25,5.4.99.15 ko:K00705,ko:K06044 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R01824,R05196,R09995 RC00049 ko00000,ko00001,ko00002,ko01000 - GH13,GH77 - Glyco_hydro_77 k59_821681_1 360094.PXO_00605 2.75e-10 57.4 COG5508@1|root,COG5508@2|Bacteria,1QBN7@1224|Proteobacteria,1SGI9@1236|Gammaproteobacteria,1X8XH@135614|Xanthomonadales 135614|Xanthomonadales S Protein of unknown function (DUF1674) - - - - - - - - - - - - DUF1674 k59_821681_2 1122137.AQXF01000001_gene3400 1.86e-96 300.0 28IA1@1|root,2Z8CN@2|Bacteria,1QTRI@1224|Proteobacteria,2U31S@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_1442041_1 655815.ZPR_2953 7.9e-51 174.0 COG0246@1|root,COG0246@2|Bacteria,4NEMT@976|Bacteroidetes,1I085@117743|Flavobacteriia 976|Bacteroidetes G PFAM Mannitol dehydrogenase C-terminal domain uxaB GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006063,GO:0006082,GO:0008150,GO:0008152,GO:0009026,GO:0009056,GO:0009987,GO:0016052,GO:0016054,GO:0016491,GO:0016614,GO:0016616,GO:0019586,GO:0019698,GO:0019752,GO:0032787,GO:0036094,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046395,GO:0046396,GO:0046397,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0071704,GO:0072329,GO:0097159,GO:1901265,GO:1901363,GO:1901575 1.1.1.17,1.1.1.58 ko:K00009,ko:K00041 ko00040,ko00051,ko01100,map00040,map00051,map01100 M00631 R02555,R02703 RC00085 ko00000,ko00001,ko00002,ko01000 - - - Mannitol_dh,Mannitol_dh_C k59_34079_1 1121344.JHZO01000007_gene2114 1.14e-35 132.0 COG1924@1|root,COG1924@2|Bacteria,1TQSD@1239|Firmicutes,2481W@186801|Clostridia,3WI11@541000|Ruminococcaceae 186801|Clostridia I BadF/BadG/BcrA/BcrD ATPase family - - - - - - - - - - - - BcrAD_BadFG,HGD-D k59_258993_1 479434.Sthe_2394 1.19e-30 122.0 COG0635@1|root,COG0635@2|Bacteria,2G5NK@200795|Chloroflexi,27XYQ@189775|Thermomicrobia 189775|Thermomicrobia H Involved in the biosynthesis of porphyrin-containing compound - - - - - - - - - - - - HemN_C,Radical_SAM k59_34104_1 436308.Nmar_0206 4.51e-127 380.0 COG1042@1|root,arCOG01340@2157|Archaea,41S6N@651137|Thaumarchaeota 651137|Thaumarchaeota C Succinyl-CoA ligase like flavodoxin domain - - - ko:K18593 ko00720,ko01120,map00720,map01120 - R10758 RC00004,RC00014 ko00000,ko00001,ko01000 - - - ATP-grasp_5,CoA_binding_2,Succ_CoA_lig k59_1669296_1 1500257.JQNM01000015_gene3048 1.39e-28 114.0 COG2081@1|root,COG2081@2|Bacteria,1MUGC@1224|Proteobacteria,2TR1K@28211|Alphaproteobacteria,4B85K@82115|Rhizobiaceae 28211|Alphaproteobacteria S HI0933-like protein - - - ko:K07007 - - - - ko00000 - - - HI0933_like k59_1669296_3 639030.JHVA01000001_gene3937 1.74e-09 61.2 COG0746@1|root,COG0746@2|Bacteria,3Y5GH@57723|Acidobacteria,2JJWH@204432|Acidobacteriia 204432|Acidobacteriia H Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor mobA - 2.7.7.77 ko:K03752 ko00790,ko01100,map00790,map01100 - R11581 - ko00000,ko00001,ko01000 - - - NTP_transf_3 k59_425891_1 247633.GP2143_09832 1.31e-56 187.0 COG2273@1|root,COG2273@2|Bacteria,1NFHX@1224|Proteobacteria,1RRPK@1236|Gammaproteobacteria 1236|Gammaproteobacteria G COG2273 Beta-glucanase Beta-glucan synthetase - - - - - - - - - - - - Glyco_hydro_16 k59_763734_1 1121921.KB898707_gene908 2.2e-12 65.5 COG4103@1|root,COG4103@2|Bacteria,1N6YZ@1224|Proteobacteria,1SD1K@1236|Gammaproteobacteria,2PNVV@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria S Tellurite resistance protein TerB - - - - - - - - - - - - TerB k59_763734_2 396588.Tgr7_1108 8.1e-43 144.0 COG3439@1|root,COG3439@2|Bacteria,1RH9Z@1224|Proteobacteria,1S73Y@1236|Gammaproteobacteria,1X24K@135613|Chromatiales 135613|Chromatiales S Domain of unknown function DUF302 - - - - - - - - - - - - DUF302 k59_763734_3 1123253.AUBD01000004_gene1059 3.89e-31 113.0 COG0640@1|root,COG0640@2|Bacteria,1N72Q@1224|Proteobacteria,1SCH5@1236|Gammaproteobacteria,1X7P3@135614|Xanthomonadales 135614|Xanthomonadales K transcriptional - - - - - - - - - - - - HTH_5 k59_933702_1 525904.Tter_1610 2.74e-24 106.0 COG0728@1|root,COG0728@2|Bacteria,2NNX8@2323|unclassified Bacteria 2|Bacteria U Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane murJ - - ko:K03980 - - - - ko00000,ko01011,ko02000 2.A.66.4 - - MVIN k59_1162022_1 706587.Desti_1505 5.67e-39 145.0 COG0477@1|root,COG2814@2|Bacteria,1MUZ8@1224|Proteobacteria,42YIF@68525|delta/epsilon subdivisions,2WU4S@28221|Deltaproteobacteria,2MQET@213462|Syntrophobacterales 28221|Deltaproteobacteria EGP PFAM Major Facilitator Superfamily - - - ko:K08218 ko01501,map01501 M00628 - - ko00000,ko00001,ko00002,ko02000 2.A.1.25 - - MFS_1 k59_1103621_1 765420.OSCT_1033 1.94e-09 62.0 2DRD4@1|root,33B9X@2|Bacteria,2G7IX@200795|Chloroflexi,377N6@32061|Chloroflexia 32061|Chloroflexia - - - - - - - - - - - - - - - k59_34128_1 1123354.AUDR01000012_gene1723 1.78e-14 72.4 2DP14@1|root,3303I@2|Bacteria,1NEU1@1224|Proteobacteria,2VWRD@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_34128_2 203122.Sde_1225 5.09e-40 140.0 COG0705@1|root,COG0705@2|Bacteria,1MYFP@1224|Proteobacteria,1RZ5Q@1236|Gammaproteobacteria,46767@72275|Alteromonadaceae 1236|Gammaproteobacteria S membrane protein (homolog of Drosophila rhomboid) - - - - - - - - - - - - Rhomboid k59_1669311_1 266117.Rxyl_3138 8.16e-115 340.0 COG1533@1|root,COG1533@2|Bacteria,2GM31@201174|Actinobacteria,4CQAG@84995|Rubrobacteria 84995|Rubrobacteria L Radical SAM - - - - - - - - - - - - Radical_SAM k59_1329232_1 1227487.C474_14744 6.23e-30 122.0 COG1250@1|root,arCOG00249@2157|Archaea,2XT6B@28890|Euryarchaeota,23SIF@183963|Halobacteria 183963|Halobacteria I Belongs to the enoyl-CoA hydratase isomerase family hbd2 - 1.1.1.35,4.2.1.17 ko:K15016 ko00720,ko01120,ko01200,map00720,map01120,map01200 M00374,M00375 R01975,R03026 RC00117,RC00831 ko00000,ko00001,ko00002,ko01000 - - - 3HCDH,3HCDH_N,ECH_1 k59_373749_1 1121406.JAEX01000002_gene863 1.96e-53 173.0 2ACTC@1|root,312E7@2|Bacteria,1R49I@1224|Proteobacteria,42UZT@68525|delta/epsilon subdivisions,2WQP3@28221|Deltaproteobacteria,2MDPD@213115|Desulfovibrionales 28221|Deltaproteobacteria S Protein of unknown function (DUF3486) - - - - - - - - - - - - DUF3486 k59_1390348_1 1437824.BN940_11026 3.81e-06 51.6 COG0596@1|root,COG0596@2|Bacteria,1MVVX@1224|Proteobacteria,2VH81@28216|Betaproteobacteria,3T9HH@506|Alcaligenaceae 28216|Betaproteobacteria S Alpha/beta hydrolase family phaY2 - - - - - - - - - - - Abhydrolase_1,Abhydrolase_6 k59_1390348_2 215803.DB30_7178 9.59e-42 145.0 COG0782@1|root,COG0782@2|Bacteria,1MZNI@1224|Proteobacteria,42VKP@68525|delta/epsilon subdivisions,2WSC9@28221|Deltaproteobacteria,2YXDH@29|Myxococcales 28221|Deltaproteobacteria K Transcription elongation factor, GreA/GreB, C-term - - - - - - - - - - - - GreA_GreB k59_933727_1 1268622.AVS7_02815 2.07e-61 205.0 COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2VIFS@28216|Betaproteobacteria,4A9PZ@80864|Comamonadaceae 28216|Betaproteobacteria C belongs to the aldehyde dehydrogenase family - - 1.2.1.3 ko:K00128 ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130 M00135 R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146 RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_1272428_1 1123240.ATVO01000006_gene1600 1.65e-51 187.0 COG1629@1|root,COG4773@1|root,COG1629@2|Bacteria,COG4773@2|Bacteria,1R479@1224|Proteobacteria,2TV3V@28211|Alphaproteobacteria,2K147@204457|Sphingomonadales 204457|Sphingomonadales P COG1629 Outer membrane receptor proteins, mostly Fe transport - - - - - - - - - - - - Plug,TonB_dep_Rec k59_1669318_1 316407.85675263 3.76e-169 483.0 COG1129@1|root,COG1129@2|Bacteria,1MU22@1224|Proteobacteria,1RMCH@1236|Gammaproteobacteria,3XNCM@561|Escherichia 1236|Gammaproteobacteria P Part of the ABC transporter complex MglABC involved in galactose methyl galactoside import. Responsible for energy coupling to the transport system mglA GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005354,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0005996,GO:0006810,GO:0006950,GO:0006974,GO:0008144,GO:0008150,GO:0008152,GO:0008643,GO:0008645,GO:0009987,GO:0015144,GO:0015145,GO:0015146,GO:0015148,GO:0015149,GO:0015399,GO:0015405,GO:0015407,GO:0015591,GO:0015592,GO:0015749,GO:0015750,GO:0015752,GO:0015753,GO:0015757,GO:0015765,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019321,GO:0022804,GO:0022857,GO:0030554,GO:0031224,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033554,GO:0034219,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042732,GO:0043167,GO:0043168,GO:0043190,GO:0043211,GO:0043492,GO:0044238,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051119,GO:0051179,GO:0051234,GO:0051716,GO:0055085,GO:0071702,GO:0071704,GO:0071944,GO:0097159,GO:0097367,GO:0098533,GO:0098796,GO:0098797,GO:1901264,GO:1901265,GO:1901363,GO:1901505,GO:1901656,GO:1902494,GO:1902495,GO:1904949,GO:1990351 3.6.3.17 ko:K02056,ko:K10441,ko:K10542,ko:K10545,ko:K10551 ko02010,map02010 M00212,M00214,M00215,M00217,M00221 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.2,3.A.1.2.1,3.A.1.2.13,3.A.1.2.19,3.A.1.2.3,3.A.1.2.4,3.A.1.2.6 - iEC55989_1330.EC55989_4224,iECED1_1282.ECED1_4821,iECED1_1282.ECED1_5085,iECH74115_1262.ECH74115_3282,iECNA114_1301.ECNA114_4270,iECSE_1348.ECSE_4039,iECSP_1301.ECSP_3027,iECW_1372.ECW_m4052,iEcE24377_1341.EcE24377A_4265,iSF_1195.SF3611,iS_1188.S4158,iWFL_1372.ECW_m4052 ABC_tran k59_1727150_1 525909.Afer_1545 2.89e-42 162.0 COG0059@1|root,COG0059@2|Bacteria,2GKXA@201174|Actinobacteria,4CMV2@84992|Acidimicrobiia 84992|Acidimicrobiia H Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate ilvC - 1.1.1.86 ko:K00053 ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R03051,R04439,R04440,R05068,R05069,R05071 RC00726,RC00836,RC00837,RC01726 ko00000,ko00001,ko00002,ko01000 - - - IlvC,IlvN k59_1669320_1 999141.GME_10346 2.53e-69 222.0 COG0055@1|root,COG0055@2|Bacteria,1MUFU@1224|Proteobacteria,1RN6U@1236|Gammaproteobacteria,1XIMC@135619|Oceanospirillales 135619|Oceanospirillales C Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits atpD - 3.6.3.14 ko:K02112 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - - ATP-synt_ab,ATP-synt_ab_N k59_1669320_2 1122604.JONR01000017_gene4315 6.88e-47 154.0 COG0355@1|root,COG0355@2|Bacteria,1RHE4@1224|Proteobacteria,1S25H@1236|Gammaproteobacteria,1X6GE@135614|Xanthomonadales 135614|Xanthomonadales C Produces ATP from ADP in the presence of a proton gradient across the membrane atpC GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016469,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0045259,GO:0045261,GO:0046034,GO:0046390,GO:0046483,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - ko:K02114 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt_DE,ATP-synt_DE_N k59_1219167_1 1288494.EBAPG3_21540 3.98e-100 305.0 COG1007@1|root,COG1007@2|Bacteria,1MV56@1224|Proteobacteria,2VHWX@28216|Betaproteobacteria,3728N@32003|Nitrosomonadales 28216|Betaproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoN - 1.6.5.3 ko:K00343 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Proton_antipo_M k59_425929_1 1122137.AQXF01000002_gene342 4.59e-94 281.0 COG2833@1|root,COG2833@2|Bacteria,1MW0V@1224|Proteobacteria,2TQJU@28211|Alphaproteobacteria 28211|Alphaproteobacteria S protein conserved in bacteria - - - - - - - - - - - - DUF455 k59_598564_1 1101192.KB910516_gene2824 8.66e-07 58.9 COG4733@1|root,COG4733@2|Bacteria,1MXXZ@1224|Proteobacteria,2TV2W@28211|Alphaproteobacteria,1JWTQ@119045|Methylobacteriaceae 28211|Alphaproteobacteria S COG4733 Phage-related protein, tail component - - - - - - - - - - - - Phage-tail_3 k59_1503458_2 1219035.NT2_10_00870 2.75e-30 112.0 COG3650@1|root,COG3650@2|Bacteria,1N3AW@1224|Proteobacteria,2UDVE@28211|Alphaproteobacteria,2KCD9@204457|Sphingomonadales 204457|Sphingomonadales S response to hydrogen peroxide - - - - - - - - - - - - - k59_1779594_1 938709.AUSH02000051_gene231 7.48e-15 77.8 COG5295@1|root,COG5295@2|Bacteria,4NVMQ@976|Bacteroidetes 976|Bacteroidetes UW Hep Hag repeat protein - - - - - - - - - - - - - k59_711713_1 991905.SL003B_0094 7.13e-18 77.0 COG0228@1|root,COG0228@2|Bacteria,1MZCT@1224|Proteobacteria,2U94X@28211|Alphaproteobacteria,4BQDT@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria J Belongs to the bacterial ribosomal protein bS16 family rpsP GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02959 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011,ko03029 - - - Ribosomal_S16 k59_711713_2 1122137.AQXF01000007_gene3540 4.4e-263 728.0 COG0541@1|root,COG0541@2|Bacteria,1MVIA@1224|Proteobacteria,2TQSW@28211|Alphaproteobacteria 28211|Alphaproteobacteria U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components ffh - 3.6.5.4 ko:K03106 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko01000,ko02044 3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9 - - SRP54,SRP54_N,SRP_SPB k59_711713_3 596151.DesfrDRAFT_3122 6.65e-07 52.0 COG5002@1|root,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,42NK9@68525|delta/epsilon subdivisions,2WMCQ@28221|Deltaproteobacteria,2MH9G@213115|Desulfovibrionales 28221|Deltaproteobacteria T response regulator, receiver - - - - - - - - - - - - HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg,SBP_bac_3 k59_536637_1 1122137.AQXF01000001_gene2641 1.41e-104 313.0 COG1960@1|root,COG1960@2|Bacteria,1MUBH@1224|Proteobacteria,2TSKH@28211|Alphaproteobacteria 28211|Alphaproteobacteria I acyl-CoA dehydrogenase - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_536637_2 1122137.AQXF01000001_gene2642 4.41e-68 218.0 COG1960@1|root,COG1960@2|Bacteria,1MVJC@1224|Proteobacteria,2TQRA@28211|Alphaproteobacteria 28211|Alphaproteobacteria I acyl-CoA dehydrogenase - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_711715_1 316067.Geob_0218 5.76e-112 340.0 COG1894@1|root,COG1894@2|Bacteria,1MV8F@1224|Proteobacteria,42N6N@68525|delta/epsilon subdivisions,2WJ1W@28221|Deltaproteobacteria 28221|Deltaproteobacteria C Respiratory-chain NADH dehydrogenase domain 51 kDa subunit bamH - 1.6.5.3 ko:K00124,ko:K00335 ko00190,ko00630,ko00680,ko01100,ko01120,ko01200,map00190,map00630,map00680,map01100,map01120,map01200 M00144 R00519,R11945 RC00061,RC02796 ko00000,ko00001,ko00002,ko01000 3.D.1 - iAF987.Gmet_2080 2Fe-2S_thioredx,Complex1_51K,Fer4,NADH_4Fe-4S,SLBB k59_1390386_1 649639.Bcell_0856 4.51e-11 65.5 COG1595@1|root,COG1595@2|Bacteria,1V7WA@1239|Firmicutes,4HK4Z@91061|Bacilli,1ZER0@1386|Bacillus 91061|Bacilli K Belongs to the sigma-70 factor family. ECF subfamily - - - - - - - - - - - - Sigma70_r2,Sigma70_r4_2 k59_1614577_1 349124.Hhal_1582 3.2e-97 296.0 COG0174@1|root,COG0174@2|Bacteria,1MUGQ@1224|Proteobacteria,1RMD1@1236|Gammaproteobacteria,1WVZ2@135613|Chromatiales 135613|Chromatiales E TIGRFAM glutamine synthetase, type I glnA - 6.3.1.2 ko:K01915 ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 - R00253 RC00010,RC02798 ko00000,ko00001,ko01000,ko04147 - - - Gln-synt_C,Gln-synt_N k59_259095_1 1122137.AQXF01000005_gene1216 4.41e-67 214.0 COG0657@1|root,COG0657@2|Bacteria,1RD8A@1224|Proteobacteria,2U1B8@28211|Alphaproteobacteria 28211|Alphaproteobacteria I Alpha beta hydrolase - - - - - - - - - - - - Abhydrolase_3 k59_259095_2 314285.KT71_03402 3.44e-24 103.0 COG2015@1|root,COG2015@2|Bacteria,1MU82@1224|Proteobacteria,1RMHR@1236|Gammaproteobacteria,1J8J5@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria Q Alkyl sulfatase dimerisation - - - - - - - - - - - - Alkyl_sulf_C,Alkyl_sulf_dimr,Lactamase_B k59_763790_1 1265313.HRUBRA_02711 2.6e-19 91.7 COG1629@1|root,COG4771@2|Bacteria 2|Bacteria P TonB-dependent receptor - - - ko:K02014,ko:K16087 - - - - ko00000,ko02000 1.B.14,1.B.14.2 - - CarbopepD_reg_2,Plug,TonB_dep_Rec k59_882178_1 644966.Tmar_0292 0.000162 49.7 COG0747@1|root,COG0747@2|Bacteria,1TQ0N@1239|Firmicutes,25CDM@186801|Clostridia 186801|Clostridia E Family 5 - - - ko:K02035 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - SBP_bac_5 k59_373803_1 882.DVU_2976 1.13e-21 94.4 COG1683@1|root,COG3272@1|root,COG1683@2|Bacteria,COG3272@2|Bacteria,1MXYZ@1224|Proteobacteria,42M4E@68525|delta/epsilon subdivisions,2WKFT@28221|Deltaproteobacteria,2M938@213115|Desulfovibrionales 28221|Deltaproteobacteria S Protein of unknown function (DUF1722) - - - - - - - - - - - - DUF1722,DUF523 k59_373803_2 203122.Sde_2627 1.19e-08 60.5 COG1215@1|root,COG1215@2|Bacteria,1RA3Y@1224|Proteobacteria,1S2MD@1236|Gammaproteobacteria 1236|Gammaproteobacteria M transferase activity, transferring glycosyl groups - - - - - - - - - - - - - k59_317218_1 436308.Nmar_0826 2.25e-27 101.0 arCOG10551@1|root,arCOG10551@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_882185_1 1121445.ATUZ01000013_gene1070 3.35e-06 48.1 COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,42MMK@68525|delta/epsilon subdivisions,2WJC1@28221|Deltaproteobacteria,2M8SI@213115|Desulfovibrionales 28221|Deltaproteobacteria S PFAM ABC transporter related yjjK - 3.6.3.25 ko:K06020 - - - - ko00000,ko01000 - - - ABC_tran,ABC_tran_Xtn k59_882185_2 1177181.T9A_00112 1.73e-22 96.7 290UJ@1|root,2ZNGJ@2|Bacteria,1RBSP@1224|Proteobacteria,1S3RZ@1236|Gammaproteobacteria,1XKS8@135619|Oceanospirillales 135619|Oceanospirillales - - - - - - - - - - - - - - - k59_34198_1 1122137.AQXF01000003_gene1963 8.26e-112 344.0 COG4772@1|root,COG4772@2|Bacteria,1NTC4@1224|Proteobacteria,2U3CZ@28211|Alphaproteobacteria 28211|Alphaproteobacteria P TonB dependent receptor - - - - - - - - - - - - Plug,TonB_dep_Rec k59_317221_1 1122137.AQXF01000001_gene3404 2.21e-41 139.0 COG0071@1|root,COG0071@2|Bacteria,1R9Y1@1224|Proteobacteria,2UA1J@28211|Alphaproteobacteria 28211|Alphaproteobacteria O Belongs to the small heat shock protein (HSP20) family hspH - - ko:K04080 - - - - ko00000,ko03110 - - - HSP20 k59_317221_2 1123366.TH3_18764 2.36e-47 156.0 COG0432@1|root,COG0432@2|Bacteria,1RH13@1224|Proteobacteria,2U945@28211|Alphaproteobacteria,2JSTR@204441|Rhodospirillales 204441|Rhodospirillales S Uncharacterised protein family UPF0047 - - - - - - - - - - - - UPF0047 k59_373817_1 1229909.NSED_05625 4.37e-63 203.0 COG0614@1|root,arCOG04233@2157|Archaea,41SXD@651137|Thaumarchaeota 651137|Thaumarchaeota P Periplasmic binding protein - - - ko:K02016 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko02000 3.A.1.14 - - Peripla_BP_2 k59_997583_1 580332.Slit_2233 1.89e-96 311.0 COG1197@1|root,COG1197@2|Bacteria,1MUXG@1224|Proteobacteria,2VI7M@28216|Betaproteobacteria,44UYD@713636|Nitrosomonadales 28216|Betaproteobacteria L Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site mfd - - ko:K03723 ko03420,map03420 - - - ko00000,ko00001,ko01000,ko03400 - - - CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF k59_720766_1 1333998.M2A_2119 2.57e-21 87.8 COG0432@1|root,COG0432@2|Bacteria,1RH13@1224|Proteobacteria,2U945@28211|Alphaproteobacteria,4BQPZ@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria S Uncharacterised protein family UPF0047 - - - - - - - - - - - - UPF0047 k59_720766_2 745310.G432_15655 2.21e-08 62.0 COG0596@1|root,COG0596@2|Bacteria,1QU30@1224|Proteobacteria,2TSNY@28211|Alphaproteobacteria,2KCXI@204457|Sphingomonadales 204457|Sphingomonadales S Serine aminopeptidase, S33 - - - - - - - - - - - - Abhydrolase_1 k59_325848_1 436308.Nmar_1104 4.16e-122 374.0 COG0178@1|root,arCOG04694@2157|Archaea,41T01@651137|Thaumarchaeota 651137|Thaumarchaeota L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate uvrA - - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - ABC_tran k59_941832_1 435908.IDSA_04675 1.58e-22 95.5 2ANPA@1|root,31DNS@2|Bacteria,1RHTE@1224|Proteobacteria,1S78C@1236|Gammaproteobacteria,2QG38@267893|Idiomarinaceae 1236|Gammaproteobacteria S Protein of unknown function (DUF3833) PP2730 - - - - - - - - - - - DUF3833 k59_489438_1 436308.Nmar_0479 2.95e-118 349.0 COG0226@1|root,arCOG00213@2157|Archaea,41SXU@651137|Thaumarchaeota 651137|Thaumarchaeota P TIGRFAM phosphate ABC transporter - - - ko:K02040 ko02010,ko02020,ko05152,map02010,map02020,map05152 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - PBP_like_2 k59_941838_1 1452535.JARD01000015_gene609 4.05e-07 57.8 COG2358@1|root,COG2358@2|Bacteria,2GKQJ@201174|Actinobacteria,4FNNQ@85023|Microbacteriaceae 201174|Actinobacteria S NMT1-like family - - - ko:K07080 - - - - ko00000 - - - NMT1_3 k59_1226830_1 436308.Nmar_1320 1.8e-94 298.0 COG1205@1|root,arCOG00555@2157|Archaea,41SZS@651137|Thaumarchaeota 651137|Thaumarchaeota L DEAD DEAH box helicase - - - ko:K06877 - - - - ko00000 - - - DEAD,DUF1998,Helicase_C k59_433765_1 1175306.GWL_01080 1.24e-64 208.0 COG1409@1|root,COG1409@2|Bacteria,1MWKX@1224|Proteobacteria,2VN1A@28216|Betaproteobacteria 28216|Betaproteobacteria P Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes cpdA - 3.1.4.53 ko:K03651 ko00230,ko02025,map00230,map02025 - R00191 RC00296 ko00000,ko00001,ko01000 - - - Metallophos k59_1399258_1 1415778.JQMM01000001_gene970 1.03e-77 246.0 COG0733@1|root,COG0733@2|Bacteria,1MUZJ@1224|Proteobacteria,1RPCT@1236|Gammaproteobacteria,1J5IR@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria U Belongs to the sodium neurotransmitter symporter (SNF) (TC 2.A.22) family IV02_29000 - - ko:K03308 - - - - ko00000 2.A.22.4,2.A.22.5 - - SNF k59_489456_1 1229909.NSED_08250 3.2e-128 370.0 COG0338@1|root,arCOG03416@2157|Archaea,41SHH@651137|Thaumarchaeota 651137|Thaumarchaeota L PFAM D12 class N6 adenine-specific DNA methyltransferase - - 2.1.1.72 ko:K06223 ko03430,map03430 - - - ko00000,ko00001,ko01000,ko02048,ko03032,ko03400 - - - MethyltransfD12 k59_267807_1 1429851.X548_15270 5.09e-37 138.0 COG0405@1|root,COG0405@2|Bacteria,1MUV6@1224|Proteobacteria,1RMIT@1236|Gammaproteobacteria,1X3TV@135614|Xanthomonadales 135614|Xanthomonadales M gamma-glutamyltransferase - - 2.3.2.2,3.4.19.13 ko:K00681 ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100 - R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935 RC00064,RC00090,RC00096 ko00000,ko00001,ko01000,ko01002 - - - G_glu_transpept k59_267807_2 391735.Veis_1623 1.38e-31 121.0 COG0180@1|root,COG3422@1|root,COG0180@2|Bacteria,COG3422@2|Bacteria,1MV4T@1224|Proteobacteria,2VIEY@28216|Betaproteobacteria,4AAEU@80864|Comamonadaceae 28216|Betaproteobacteria J PFAM aminoacyl-tRNA synthetase class Ib trpS GO:0003674,GO:0003824,GO:0004812,GO:0004830,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006436,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.2 ko:K01867 ko00970,map00970 M00359,M00360 R03664 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DUF1508,tRNA-synt_1b k59_1511955_1 1265313.HRUBRA_00251 1.42e-74 232.0 COG1062@1|root,COG1062@2|Bacteria,1MUK4@1224|Proteobacteria,1RNQ4@1236|Gammaproteobacteria,1J4MG@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily adhC GO:0003674,GO:0003824,GO:0004022,GO:0004024,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0008150,GO:0008152,GO:0008270,GO:0009056,GO:0009636,GO:0009987,GO:0010033,GO:0016491,GO:0016614,GO:0016616,GO:0016999,GO:0017001,GO:0017144,GO:0042221,GO:0042802,GO:0043167,GO:0043169,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046185,GO:0046292,GO:0046294,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0051903,GO:0055114,GO:0070887,GO:0071704,GO:0097237,GO:0098754,GO:0110095,GO:0110096,GO:1901575,GO:1901700,GO:1901701,GO:1990748 1.1.1.1,1.1.1.284 ko:K00121 ko00010,ko00071,ko00350,ko00625,ko00626,ko00680,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,ko05204,map00010,map00071,map00350,map00625,map00626,map00680,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01200,map01220,map05204 - R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R06983,R07105,R08281,R08306,R08310 RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01715,RC01734,RC02273 ko00000,ko00001,ko01000 - - iEC042_1314.EC042_0393,iEC55989_1330.EC55989_0365,iECH74115_1262.ECH74115_0431,iECIAI1_1343.ECIAI1_0357,iECIAI39_1322.ECIAI39_0322,iECO103_1326.ECO103_0338,iECO111_1330.ECO111_0392,iECO26_1355.ECO26_0392,iECSE_1348.ECSE_0381,iECSP_1301.ECSP_0420,iECUMN_1333.ECUMN_0399,iECW_1372.ECW_m0434,iECs_1301.ECs0411,iEKO11_1354.EKO11_3486,iETEC_1333.ETEC_0412,iEcE24377_1341.EcE24377A_0381,iEcHS_1320.EcHS_A0421,iEcolC_1368.EcolC_3269,iG2583_1286.G2583_0469,iSSON_1240.SSON_0335,iSbBS512_1146.SbBS512_E0271,iUMNK88_1353.UMNK88_407,iWFL_1372.ECW_m0434,iZ_1308.Z0456 ADH_N,ADH_zinc_N k59_1569650_1 1121479.AUBS01000041_gene658 9.33e-70 226.0 COG0055@1|root,COG0055@2|Bacteria,1N6UZ@1224|Proteobacteria,2TT70@28211|Alphaproteobacteria 28211|Alphaproteobacteria C Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits atpD_2 - 3.6.3.14 ko:K02112 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - - ATP-synt_ab,ATP-synt_ab_N k59_1569650_2 1458357.BG58_16910 6.39e-18 80.9 COG0355@1|root,COG0355@2|Bacteria,1N0ZB@1224|Proteobacteria,2VYP4@28216|Betaproteobacteria,1K9GZ@119060|Burkholderiaceae 28216|Betaproteobacteria C Produces ATP from ADP in the presence of a proton gradient across the membrane - - - ko:K02114 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt_DE_N k59_489462_1 400668.Mmwyl1_1250 1.93e-05 53.9 COG0642@1|root,COG0745@1|root,COG2199@1|root,COG0745@2|Bacteria,COG2205@2|Bacteria,COG3706@2|Bacteria,1NRP8@1224|Proteobacteria,1SKTW@1236|Gammaproteobacteria,1XIAY@135619|Oceanospirillales 135619|Oceanospirillales T Histidine kinase gacS - 2.7.13.3 ko:K07678 ko02020,ko02025,ko02026,ko05111,map02020,map02025,map02026,map05111 M00475 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - DUF2222,HAMP,HATPase_c,HisKA,Hpt,Response_reg k59_544602_2 313628.LNTAR_07384 3.58e-16 79.7 COG3181@1|root,COG3181@2|Bacteria 2|Bacteria E Tripartite tricarboxylate transporter family receptor - - - - - - - - - - - - TctC k59_152751_1 935557.ATYB01000010_gene570 2.72e-16 75.9 COG0071@1|root,COG0071@2|Bacteria,1N7C7@1224|Proteobacteria,2UFRX@28211|Alphaproteobacteria,4BEM4@82115|Rhizobiaceae 28211|Alphaproteobacteria O Belongs to the small heat shock protein (HSP20) family hspC2 - - ko:K13993 ko04141,map04141 - - - ko00000,ko00001,ko03110 - - - HSP20 k59_607602_1 391603.FBALC1_02732 1.59e-32 123.0 COG0065@1|root,COG0065@2|Bacteria,4NG7E@976|Bacteroidetes,1HWPT@117743|Flavobacteriia 976|Bacteroidetes E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate leuC - 4.2.1.33,4.2.1.35 ko:K01703 ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230 M00432,M00535 R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170 RC00497,RC00976,RC00977,RC01041,RC01046,RC03072 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase k59_607602_2 983544.Lacal_0597 3.07e-73 223.0 COG0066@1|root,COG0066@2|Bacteria,4NDVY@976|Bacteroidetes,1HXVV@117743|Flavobacteriia 976|Bacteroidetes E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate leuD - 4.2.1.33,4.2.1.35 ko:K01704 ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230 M00432,M00535 R03896,R03898,R03968,R04001,R10170 RC00976,RC00977,RC01041,RC01046,RC03072 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase_C k59_152755_1 1208321.D104_06820 7.15e-77 234.0 COG0097@1|root,COG0097@2|Bacteria,1R9YZ@1224|Proteobacteria,1S1Z1@1236|Gammaproteobacteria,1XJA3@135619|Oceanospirillales 135619|Oceanospirillales J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center rplF - - ko:K02933 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L6 k59_152755_2 1492922.GY26_02940 3.01e-55 174.0 COG0256@1|root,COG0256@2|Bacteria,1RGY7@1224|Proteobacteria,1S5V2@1236|Gammaproteobacteria,1J664@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance rplR GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02881 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L18p k59_1170856_1 402881.Plav_1021 4.06e-30 118.0 COG4221@1|root,COG4221@2|Bacteria,1MVYG@1224|Proteobacteria,2TSTP@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Belongs to the short-chain dehydrogenases reductases (SDR) family - - - - - - - - - - - - adh_short k59_544612_1 1231391.AMZF01000013_gene2634 3.18e-08 57.4 COG0285@1|root,COG0285@2|Bacteria,1MVCH@1224|Proteobacteria,2VI0H@28216|Betaproteobacteria,3T1IK@506|Alcaligenaceae 28216|Betaproteobacteria H Belongs to the folylpolyglutamate synthase family folC - 6.3.2.12,6.3.2.17 ko:K11754 ko00790,ko01100,map00790,map01100 M00126,M00841 R00942,R02237,R04241 RC00064,RC00090,RC00162 ko00000,ko00001,ko00002,ko01000 - - - Mur_ligase_C,Mur_ligase_M k59_607607_1 1033802.SSPSH_002659 5.35e-132 390.0 COG0364@1|root,COG0364@2|Bacteria,1MUN0@1224|Proteobacteria,1RN76@1236|Gammaproteobacteria 1236|Gammaproteobacteria G Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone zwf - 1.1.1.363,1.1.1.49 ko:K00036 ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230 M00004,M00006,M00008 R00835,R02736,R10907 RC00001,RC00066 ko00000,ko00001,ko00002,ko01000,ko04147 - - - G6PD_C,G6PD_N k59_210319_2 1415780.JPOG01000001_gene279 7.95e-34 130.0 COG2609@1|root,COG2609@2|Bacteria,1MV21@1224|Proteobacteria,1RN6K@1236|Gammaproteobacteria,1X3YZ@135614|Xanthomonadales 135614|Xanthomonadales C Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) aceE - 1.2.4.1 ko:K00163 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200 M00307 R00014,R00209,R01699,R03270 RC00004,RC00027,RC00627,RC02742,RC02744,RC02882 br01601,ko00000,ko00001,ko00002,ko01000 - - - Transketolase_N k59_1787081_1 324057.Pjdr2_3113 1.48e-37 135.0 COG1309@1|root,COG1309@2|Bacteria,1US3R@1239|Firmicutes,4HCGK@91061|Bacilli,276XX@186822|Paenibacillaceae 91061|Bacilli K Bacterial transcriptional repressor C-terminal - - - ko:K16137 - - - - ko00000,ko03000 - - - TetR_C_13,TetR_N k59_1787085_1 596152.DesU5LDRAFT_0469 2.27e-48 165.0 COG0730@1|root,COG0730@2|Bacteria,1Q59Y@1224|Proteobacteria,430VR@68525|delta/epsilon subdivisions,2WVKN@28221|Deltaproteobacteria,2M8GD@213115|Desulfovibrionales 28221|Deltaproteobacteria S membrane transporter protein - - - ko:K07090 - - - - ko00000 - - - TauE k59_267842_1 1122137.AQXF01000006_gene744 2.1e-103 311.0 COG0665@1|root,COG0665@2|Bacteria,1MVGP@1224|Proteobacteria,2TRX9@28211|Alphaproteobacteria 28211|Alphaproteobacteria E oxidoreductase - - - ko:K09471 ko00330,ko01100,map00330,map01100 M00136 R07415 RC00062 ko00000,ko00001,ko00002,ko01000 - - - DAO k59_433803_1 292.DM42_6311 8.09e-132 387.0 COG1960@1|root,COG1960@2|Bacteria,1MXMQ@1224|Proteobacteria,2VNPR@28216|Betaproteobacteria,1JZST@119060|Burkholderiaceae 28216|Betaproteobacteria I acyl-CoA dehydrogenase - - 1.14.14.12 ko:K16047 ko00984,ko01100,ko01120,map00984,map01100,map01120 - R09819 RC00236 ko00000,ko00001,ko01000 - - - Acyl-CoA_dh_2,Acyl-CoA_dh_N k59_433803_2 1123020.AUIE01000009_gene3820 3.45e-106 316.0 COG2267@1|root,COG2267@2|Bacteria,1MZG8@1224|Proteobacteria,1RQYM@1236|Gammaproteobacteria,1YHNU@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria I alpha/beta hydrolase fold mhpC - 3.7.1.17 ko:K16050 ko00984,ko01100,ko01120,ko01220,map00984,map01100,map01120,map01220 - R09883 RC02018,RC02740 ko00000,ko00001,ko01000 - - - Abhydrolase_1,Abhydrolase_6 k59_433803_3 497321.C664_07418 1.05e-77 239.0 COG3971@1|root,COG3971@2|Bacteria,1MVVV@1224|Proteobacteria,2VKJE@28216|Betaproteobacteria,2KZRG@206389|Rhodocyclales 206389|Rhodocyclales Q 2-keto-4-pentenoate hydratase - - - - - - - - - - - - FAA_hydrolase k59_1399309_1 323848.Nmul_A2666 1.2e-57 195.0 COG0843@1|root,COG0843@2|Bacteria,1PVEV@1224|Proteobacteria,2VK5Q@28216|Betaproteobacteria,372M7@32003|Nitrosomonadales 28216|Betaproteobacteria C Cytochrome C and Quinol oxidase polypeptide I coxA2 - 1.9.3.1 ko:K02274 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6 - - COX1 k59_1787095_1 316407.85676207 8.42e-168 488.0 COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,1RMZ8@1236|Gammaproteobacteria,3XMBN@561|Escherichia 1236|Gammaproteobacteria I Involved in the aerobic and anaerobic degradation of long-chain fatty acids via beta-oxidation cycle. Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA. It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate fadB GO:0003674,GO:0003824,GO:0003857,GO:0004165,GO:0004300,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0008692,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016491,GO:0016614,GO:0016616,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016854,GO:0016856,GO:0016860,GO:0016863,GO:0019395,GO:0019752,GO:0030258,GO:0032787,GO:0034440,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0046395,GO:0055114,GO:0071704,GO:0072329,GO:1901575 1.1.1.35,4.2.1.17,5.1.2.3,5.3.3.8 ko:K01782,ko:K01825 ko00071,ko00280,ko00281,ko00310,ko00362,ko00380,ko00410,ko00640,ko00650,ko00903,ko00930,ko01040,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00362,map00380,map00410,map00640,map00650,map00903,map00930,map01040,map01100,map01110,map01120,map01130,map01200,map01212 M00032,M00087 R01975,R03026,R03045,R03276,R04137,R04170,R04203,R04204,R04224,R04737,R04738,R04739,R04740,R04741,R04744,R04745,R04746,R04748,R04749,R04756,R05066,R05305,R06411,R06412,R06941,R06942,R07935,R07951,R08093,R08094 RC00029,RC00099,RC00117,RC00241,RC00525,RC00831,RC00834,RC00896,RC01078,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 - - iLF82_1304.LF82_0614,iNRG857_1313.NRG857_19200 3HCDH,3HCDH_N,ECH_1 k59_325925_1 222534.KB893721_gene973 3.49e-86 272.0 COG1075@1|root,COG1075@2|Bacteria,2HXFM@201174|Actinobacteria,4EVG2@85013|Frankiales 201174|Actinobacteria S Lipase (class 2) - - - - - - - - - - - - Lipase_2 k59_489497_1 1144307.PMI04_03273 5.55e-116 344.0 COG0438@1|root,COG0438@2|Bacteria,1NMB5@1224|Proteobacteria,2UNM2@28211|Alphaproteobacteria,2K3G7@204457|Sphingomonadales 204457|Sphingomonadales M Sulfotransferase domain - - - - - - - - - - - - Sulfotransfer_3 k59_1059076_1 981369.JQMJ01000004_gene2935 2.7e-60 196.0 COG0745@1|root,COG0745@2|Bacteria,2GK5S@201174|Actinobacteria,2NH5C@228398|Streptacidiphilus 201174|Actinobacteria T Transcriptional regulatory protein, C terminal resD - - - - - - - - - - - Response_reg,Trans_reg_C k59_1059076_2 682795.AciX8_0551 2.14e-10 60.8 COG0704@1|root,COG0704@2|Bacteria,3Y4DI@57723|Acidobacteria,2JJ5M@204432|Acidobacteriia 204432|Acidobacteriia P Plays a role in the regulation of phosphate uptake - - - ko:K02039 - - - - ko00000 - - - PhoU k59_1512004_1 326297.Sama_2914 1.92e-36 129.0 COG3803@1|root,COG3803@2|Bacteria,1RHYI@1224|Proteobacteria,1S40A@1236|Gammaproteobacteria,2QBGB@267890|Shewanellaceae 1236|Gammaproteobacteria S Bacterial protein of unknown function (DUF924) - - - - - - - - - - - - DUF924 k59_1512004_2 1122137.AQXF01000002_gene386 8.5e-60 195.0 COG2234@1|root,COG2234@2|Bacteria,1PB6Y@1224|Proteobacteria 1224|Proteobacteria S Peptidase family M28 - - - - - - - - - - - - Peptidase_M28 k59_98494_1 1026882.MAMP_00789 9.87e-102 306.0 COG0223@1|root,COG0223@2|Bacteria,1MU4Q@1224|Proteobacteria,1RP1T@1236|Gammaproteobacteria,45ZQR@72273|Thiotrichales 72273|Thiotrichales J Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus fmt - 2.1.2.9 ko:K00604 ko00670,ko00970,map00670,map00970 - R03940 RC00026,RC00165 ko00000,ko00001,ko01000 - - - Formyl_trans_C,Formyl_trans_N k59_890852_1 861299.J421_4449 2.2e-81 262.0 COG0515@1|root,COG0515@2|Bacteria,1ZTFJ@142182|Gemmatimonadetes 142182|Gemmatimonadetes KLT Serine/Threonine protein kinases, catalytic domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase k59_1170879_1 638303.Thal_0953 7.38e-23 95.1 COG0440@1|root,COG0440@2|Bacteria,2G43A@200783|Aquificae 200783|Aquificae E Acetolactate synthase, small subunit ilvN GO:0003674,GO:0003824,GO:0003984,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005948,GO:0006082,GO:0006520,GO:0006549,GO:0006573,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009097,GO:0009099,GO:0009987,GO:0016053,GO:0016740,GO:0016744,GO:0019752,GO:0032991,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494,GO:1990234 2.2.1.6 ko:K01653 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - ACT,ACT_5,ALS_ss_C k59_890855_1 1395571.TMS3_0117830 9.29e-16 79.3 COG1538@1|root,COG1538@2|Bacteria,1MUHM@1224|Proteobacteria,1RNNS@1236|Gammaproteobacteria 1236|Gammaproteobacteria MU outer membrane efflux protein - - - - - - - - - - - - OEP k59_382599_1 857087.Metme_2457 2.02e-73 227.0 COG1733@1|root,COG1733@2|Bacteria,1PGWN@1224|Proteobacteria,1SXVP@1236|Gammaproteobacteria,1XGTB@135618|Methylococcales 135618|Methylococcales K HxlR-like helix-turn-helix - - - - - - - - - - - - HxlR k59_1336983_1 1160718.SU9_01640 0.000846 46.2 COG1028@1|root,COG2070@1|root,COG3321@1|root,COG1028@2|Bacteria,COG2070@2|Bacteria,COG3321@2|Bacteria,2ICPK@201174|Actinobacteria 201174|Actinobacteria IQ polyketide synthase - - - - - - - - - - - - Acyl_transf_1,KAsynt_C_assoc,KR,Ketoacyl-synt_C,NMO,PP-binding,PS-DH,ketoacyl-synt k59_98501_1 1415778.JQMM01000001_gene739 6.06e-130 384.0 COG2192@1|root,COG2192@2|Bacteria,1MWBA@1224|Proteobacteria,1RNN4@1236|Gammaproteobacteria,1J5H3@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O Carbamoyltransferase C-terminus HA62_32075 - - ko:K00612 - - - - ko00000,ko01000 - - - Carbam_trans_C,Carbam_trans_N k59_152807_1 933262.AXAM01000016_gene149 2.18e-80 265.0 COG5009@1|root,COG5009@2|Bacteria,1MU5A@1224|Proteobacteria,42MJB@68525|delta/epsilon subdivisions,2WIXF@28221|Deltaproteobacteria,2MI9W@213118|Desulfobacterales 28221|Deltaproteobacteria M TIGRFAM penicillin-binding protein, 1A family mrcA - 2.4.1.129,3.4.16.4 ko:K05366 ko00550,ko01100,ko01501,map00550,map01100,map01501 - - - ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 iAF987.Gmet_0354 PCB_OB,Transgly,Transpeptidase k59_42714_1 1122137.AQXF01000003_gene1928 3.11e-135 394.0 COG0793@1|root,COG0793@2|Bacteria,1MU39@1224|Proteobacteria,2TRW2@28211|Alphaproteobacteria 28211|Alphaproteobacteria M Belongs to the peptidase S41A family ctpA - 3.4.21.102 ko:K03797 - - - - ko00000,ko01000,ko01002 - - - PDZ,PDZ_2,Peptidase_S41 k59_890877_1 222534.KB893728_gene5477 3.86e-30 120.0 COG3842@1|root,COG3842@2|Bacteria,2GJCM@201174|Actinobacteria,4ES4E@85013|Frankiales 201174|Actinobacteria P Belongs to the ABC transporter superfamily - - - ko:K10112 ko02010,map02010 M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1 - - ABC_tran,TOBE_2 k59_1336996_1 1479235.KK366039_gene2492 4.22e-76 237.0 COG0202@1|root,COG0202@2|Bacteria,1MU75@1224|Proteobacteria,1RMU3@1236|Gammaproteobacteria,1XH9U@135619|Oceanospirillales 135619|Oceanospirillales K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoA - 2.7.7.6 ko:K03040 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_A_CTD,RNA_pol_A_bac,RNA_pol_L k59_1226889_1 998674.ATTE01000001_gene2268 4.14e-47 162.0 COG0264@1|root,COG0264@2|Bacteria,1MUS2@1224|Proteobacteria,1RPBJ@1236|Gammaproteobacteria,45ZY5@72273|Thiotrichales 72273|Thiotrichales J Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome tsf - - ko:K02357 - - - - ko00000,ko03012,ko03029 - - - EF_TS k59_720862_2 55529.EKX54527 5.56e-08 52.8 COG0271@1|root,KOG2313@2759|Eukaryota 2759|Eukaryota T protein maturation by iron-sulfur cluster transfer bola1 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0009507,GO:0009536,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464 - ko:K22066 - - - - ko00000,ko03029 - - - BolA k59_997705_1 641524.ADICYQ_5666 4.58e-61 205.0 COG0119@1|root,COG0119@2|Bacteria,4NF3N@976|Bacteroidetes,47JWF@768503|Cytophagia 976|Bacteroidetes E Belongs to the alpha-IPM synthase homocitrate synthase family leuA_1 - 2.3.1.182 ko:K09011 ko00290,ko00660,ko01100,ko01210,ko01230,map00290,map00660,map01100,map01210,map01230 M00535 R07399 RC00004,RC01205 br01601,ko00000,ko00001,ko00002,ko01000 - - - HMGL-like,LeuA_dimer k59_1735000_1 1121924.ATWH01000006_gene1737 3.59e-38 136.0 COG0031@1|root,COG0031@2|Bacteria,2IA0Z@201174|Actinobacteria,4FR72@85023|Microbacteriaceae 201174|Actinobacteria E Pyridoxal-phosphate dependent enzyme - - 2.5.1.47 ko:K01738 ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230 M00021 R00897,R03601,R04859 RC00020,RC02814,RC02821 ko00000,ko00001,ko00002,ko01000 - - - PALP k59_890883_1 1288494.EBAPG3_9670 4.7e-92 300.0 COG0085@1|root,COG0085@2|Bacteria,1MUC4@1224|Proteobacteria,2VHF3@28216|Betaproteobacteria,37253@32003|Nitrosomonadales 28216|Betaproteobacteria K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoB - 2.7.7.6 ko:K03043 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7 k59_325961_1 631454.N177_3727 1.36e-64 225.0 COG0296@1|root,COG1523@1|root,COG0296@2|Bacteria,COG1523@2|Bacteria,1MU19@1224|Proteobacteria,2TRVS@28211|Alphaproteobacteria,1JN9G@119043|Rhodobiaceae 28211|Alphaproteobacteria G Carbohydrate-binding module 48 (Isoamylase N-terminal domain) glgX - 3.2.1.196,3.2.1.68 ko:K01214,ko:K02438 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R02111,R09995,R11261 - ko00000,ko00001,ko00002,ko01000 - CBM48,GH13 - Alpha-amylase,CBM_48 k59_1677105_1 240016.ABIZ01000001_gene2770 1.41e-05 49.3 COG5002@1|root,COG5002@2|Bacteria,46TKS@74201|Verrucomicrobia 74201|Verrucomicrobia T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA,PAS_4,Response_reg k59_382623_1 944435.AXAJ01000003_gene4131 3.23e-07 55.8 COG4964@1|root,COG4964@2|Bacteria,1MV8G@1224|Proteobacteria,2VJZG@28216|Betaproteobacteria,1K349@119060|Burkholderiaceae 28216|Betaproteobacteria U Belongs to the GSP D family cpaC - - ko:K02280 - - - - ko00000,ko02035,ko02044 - - - Secretin,T2SS-T3SS_pil_N k59_99392_1 365044.Pnap_1258 3.47e-93 295.0 COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,2VH8J@28216|Betaproteobacteria,4A9KK@80864|Comamonadaceae 28216|Betaproteobacteria P heavy metal translocating P-type ATPase actP - 3.6.3.54 ko:K17686 ko01524,ko04016,map01524,map04016 - R00086 RC00002 ko00000,ko00001,ko01000 3.A.3.5 - - E1-E2_ATPase,Hydrolase,YHS k59_1678136_2 1122599.AUGR01000013_gene729 2.33e-06 52.8 COG1629@1|root,COG4771@2|Bacteria,1MUC1@1224|Proteobacteria,1RNHR@1236|Gammaproteobacteria 1236|Gammaproteobacteria P Receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_661150_1 990285.RGCCGE502_04505 7.91e-05 52.4 COG0840@1|root,COG2770@1|root,COG0840@2|Bacteria,COG2770@2|Bacteria,1MU9B@1224|Proteobacteria,2TQR7@28211|Alphaproteobacteria,4B7BQ@82115|Rhizobiaceae 28211|Alphaproteobacteria NT methyl-accepting chemotaxis protein - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - HAMP,MCPsignal,dCache_1 k59_1400542_1 400668.Mmwyl1_1317 1.27e-104 313.0 COG1600@1|root,COG1600@2|Bacteria,1MV1H@1224|Proteobacteria,1RMD9@1236|Gammaproteobacteria,1XHVG@135619|Oceanospirillales 135619|Oceanospirillales C Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) queG - 1.17.99.6 ko:K18979 - - - - ko00000,ko01000,ko03016 - - - DUF1730,Fer4_16 k59_545794_1 748247.AZKH_2385 3.41e-27 113.0 COG0750@1|root,COG0750@2|Bacteria,1MU91@1224|Proteobacteria,2VHBW@28216|Betaproteobacteria,2KV3Y@206389|Rhodocyclales 206389|Rhodocyclales M zinc metalloprotease - - - ko:K11749 ko02024,ko04112,map02024,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - PDZ,PDZ_2,Peptidase_M50 k59_942763_1 1134474.O59_000797 2.47e-52 182.0 COG0497@1|root,COG0497@2|Bacteria,1MUNP@1224|Proteobacteria,1RNPZ@1236|Gammaproteobacteria,1FG4A@10|Cellvibrio 1236|Gammaproteobacteria L May be involved in recombinational repair of damaged DNA recN GO:0000724,GO:0000725,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009314,GO:0009432,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0090304,GO:1901360 - ko:K03631 - - - - ko00000,ko03400 - - - AAA_23,SMC_N k59_1059960_1 316407.85676539 3.12e-236 650.0 COG3039@1|root,COG3039@2|Bacteria,1MVDK@1224|Proteobacteria,1RR0T@1236|Gammaproteobacteria 1236|Gammaproteobacteria L COG3039 Transposase and inactivated derivatives IS5 family - GO:0003674,GO:0003824,GO:0004803,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006310,GO:0006313,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009279,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016020,GO:0019219,GO:0019222,GO:0019867,GO:0030312,GO:0030313,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031975,GO:0032196,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044462,GO:0044464,GO:0045893,GO:0045935,GO:0046483,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0090304,GO:0140097,GO:1901360,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141 - ko:K07481 - - - - ko00000 - - - DDE_Tnp_1,DUF772 k59_545795_1 1144305.PMI02_00864 4.42e-171 484.0 COG2267@1|root,COG2267@2|Bacteria,1R9DT@1224|Proteobacteria,2VFK6@28211|Alphaproteobacteria 28211|Alphaproteobacteria I Alpha/beta hydrolase family - - - - - - - - - - - - Abhydrolase_1 k59_43530_2 472759.Nhal_2798 4.71e-71 224.0 COG0142@1|root,COG0142@2|Bacteria,1MWNG@1224|Proteobacteria,1RMKY@1236|Gammaproteobacteria,1WX2E@135613|Chromatiales 135613|Chromatiales H Belongs to the FPP GGPP synthase family - - 2.5.1.1,2.5.1.10,2.5.1.29 ko:K00795,ko:K13789 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00364,M00366 R01658,R02003,R02061 RC00279 ko00000,ko00001,ko00002,ko01000,ko01006 - - - polyprenyl_synt k59_1570614_1 349521.HCH_05431 1.18e-19 82.4 COG0640@1|root,COG0640@2|Bacteria 2|Bacteria K DNA-binding transcription factor activity - - - ko:K22042 - - - - ko00000,ko03000 - - - HTH_20,HTH_5 k59_1742503_1 1280953.HOC_18479 1.13e-145 439.0 COG4773@1|root,COG4773@2|Bacteria,1MWUQ@1224|Proteobacteria,2TTVU@28211|Alphaproteobacteria 28211|Alphaproteobacteria P COG1629 Outer membrane receptor proteins, mostly Fe transport - - - - - - - - - - - - Plug,TonB_dep_Rec k59_390752_1 1415778.JQMM01000001_gene1695 2.12e-139 408.0 COG4623@1|root,COG4623@2|Bacteria,1MWDS@1224|Proteobacteria,1RM8W@1236|Gammaproteobacteria,1J571@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella mltF GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0006022,GO:0006026,GO:0006027,GO:0006807,GO:0008150,GO:0008152,GO:0008933,GO:0009056,GO:0009057,GO:0009253,GO:0009279,GO:0016020,GO:0016740,GO:0016757,GO:0019867,GO:0030203,GO:0030312,GO:0030313,GO:0031975,GO:0043170,GO:0044462,GO:0044464,GO:0061783,GO:0071704,GO:0071944,GO:1901135,GO:1901136,GO:1901564,GO:1901565,GO:1901575 - ko:K18691 - - - - ko00000,ko01000,ko01011 - - iBWG_1329.BWG_2322,iEC042_1314.EC042_2762,iECDH1ME8569_1439.ECDH1ME8569_2485,iECNA114_1301.ECNA114_2631,iECP_1309.ECP_2560,iECSF_1327.ECSF_2397,iECW_1372.ECW_m2786,iEKO11_1354.EKO11_1175,iEcDH1_1363.EcDH1_1110,iEcHS_1320.EcHS_A2711,iEcolC_1368.EcolC_1119,iG2583_1286.G2583_3089,iJO1366.b2558,iSFxv_1172.SFxv_2861,iUMN146_1321.UM146_03930,iUMNK88_1353.UMNK88_3212,iUTI89_1310.UTI89_C2878,iWFL_1372.ECW_m2786,iY75_1357.Y75_RS13345 SBP_bac_3,SLT k59_1288815_1 377629.TERTU_0029 9.79e-63 218.0 COG5617@1|root,COG5617@2|Bacteria,1RJY5@1224|Proteobacteria,1SE0V@1236|Gammaproteobacteria,2PPHT@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria S 6-pyruvoyl-tetrahydropterin synthase related domain; membrane protein - - - - - - - - - - - - PTPS_related k59_1794885_1 1541065.JRFE01000022_gene4068 9.62e-48 159.0 COG4430@1|root,COG4430@2|Bacteria,1G2ES@1117|Cyanobacteria,3VMQG@52604|Pleurocapsales 1117|Cyanobacteria S Bacteriocin-protection, YdeI or OmpD-Associated - - - - - - - - - - - - OmdA k59_1345018_2 1177179.A11A3_03844 1.74e-22 91.3 2E7TI@1|root,3328N@2|Bacteria,1NCCK@1224|Proteobacteria,1SDE1@1236|Gammaproteobacteria 1236|Gammaproteobacteria S TRL-like protein family - - - - - - - - - - - - TRL k59_1345018_4 314287.GB2207_00700 1.2e-125 370.0 COG0625@1|root,COG0625@2|Bacteria,1Q9ND@1224|Proteobacteria 1224|Proteobacteria O COG0625 Glutathione S-transferase - - - - - - - - - - - - GST_C_2,GST_N_3 k59_1794886_1 1248760.ANFZ01000005_gene2222 1.42e-118 346.0 2AMB5@1|root,31C68@2|Bacteria,1P0NA@1224|Proteobacteria,2UUY1@28211|Alphaproteobacteria,2KB9R@204457|Sphingomonadales 204457|Sphingomonadales S Protein of unknown function (DUF1838) - - - - - - - - - - - - DUF1838 k59_217908_1 1122137.AQXF01000002_gene310 8.69e-70 229.0 COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,2TQRZ@28211|Alphaproteobacteria 28211|Alphaproteobacteria S COG0488 ATPase components of ABC transporters with duplicated ATPase domains yheS GO:0000166,GO:0003674,GO:0005488,GO:0005524,GO:0008144,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - ko:K06158 - - - - ko00000,ko03012 - - - ABC_tran,ABC_tran_CTD,ABC_tran_Xtn k59_333584_1 1191523.MROS_2077 1.7e-60 202.0 COG2211@1|root,COG2211@2|Bacteria 2|Bacteria G Major facilitator Superfamily - - - ko:K03292,ko:K16248 - - - - ko00000,ko02000 2.A.2 - - MFS_2,MFS_3 k59_1234248_1 1122137.AQXF01000003_gene2486 4.98e-96 290.0 COG0381@1|root,COG0381@2|Bacteria,1MWZN@1224|Proteobacteria,2TTGZ@28211|Alphaproteobacteria 28211|Alphaproteobacteria M Belongs to the UDP-N-acetylglucosamine 2-epimerase family wecB - 5.1.3.14 ko:K01791 ko00520,ko01100,ko05111,map00520,map01100,map05111 M00362 R00420 RC00290 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Epimerase_2 k59_1066726_1 314287.GB2207_11193 3.15e-30 122.0 COG0642@1|root,COG2205@2|Bacteria,1N1Z2@1224|Proteobacteria,1RPG9@1236|Gammaproteobacteria,1J4EW@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T His Kinase A (phosphoacceptor) domain qseC - 2.7.13.3 ko:K07645 ko02020,ko02024,map02020,map02024 M00453 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - 2CSK_N,HATPase_c,HisKA k59_441662_1 573370.DMR_17810 3.47e-47 184.0 COG0642@1|root,COG5002@1|root,COG0642@2|Bacteria,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,42NK9@68525|delta/epsilon subdivisions,2WMCQ@28221|Deltaproteobacteria,2MH9G@213115|Desulfovibrionales 28221|Deltaproteobacteria T response regulator, receiver - - - - - - - - - - - - GAF_2,HATPase_c,HisKA,Hpt,PAS_4,Response_reg k59_496999_1 1122194.AUHU01000013_gene722 4.83e-28 113.0 COG3178@1|root,COG3178@2|Bacteria,1MXCH@1224|Proteobacteria,1RQ1Q@1236|Gammaproteobacteria,466NT@72275|Alteromonadaceae 1236|Gammaproteobacteria S phosphotransferase related to Ser Thr protein kinases - GO:0000166,GO:0000270,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005975,GO:0006022,GO:0006040,GO:0006082,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009254,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0017076,GO:0019200,GO:0019752,GO:0030203,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0046835,GO:0071704,GO:0097159,GO:0097172,GO:0097367,GO:1901135,GO:1901265,GO:1901363,GO:1901564 2.7.1.221 ko:K07102 ko00520,ko01100,map00520,map01100 - R08968,R11024 RC00002,RC00078 ko00000,ko00001,ko01000 - - - APH k59_1630242_1 1144305.PMI02_03645 5.42e-95 284.0 COG0002@1|root,COG0002@2|Bacteria,1MVJ6@1224|Proteobacteria,2TRMT@28211|Alphaproteobacteria,2K2G3@204457|Sphingomonadales 204457|Sphingomonadales E Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde argC - 1.2.1.38 ko:K00145 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028,M00845 R03443 RC00684 ko00000,ko00001,ko00002,ko01000 - - - Semialdhyde_dh k59_50365_2 258533.BN977_00580 3.19e-55 184.0 COG0123@1|root,COG0123@2|Bacteria,2GJUH@201174|Actinobacteria,235D7@1762|Mycobacteriaceae 201174|Actinobacteria BQ Histone deacetylase domain hdaH - - ko:K04768 - - - - ko00000 - - - Hist_deacetyl k59_1630251_1 485913.Krac_10415 1.35e-65 209.0 COG3385@1|root,COG3385@2|Bacteria 2|Bacteria L transposase activity - - - - - - - - - - - - DDE_5,DDE_Tnp_1 k59_1685520_1 1122137.AQXF01000005_gene1253 1.48e-22 97.1 COG2207@1|root,COG2207@2|Bacteria,1MX23@1224|Proteobacteria,2TT6H@28211|Alphaproteobacteria 28211|Alphaproteobacteria K transcriptional regulator, AraC family - - - - - - - - - - - - Arabinose_bd,HTH_18 k59_106392_1 1236902.ANAS01000012_gene787 1.59e-23 92.0 COG3526@1|root,COG3526@2|Bacteria,2IRQ4@201174|Actinobacteria 201174|Actinobacteria O Rdx family - - - ko:K07401 - - - - ko00000 - - - Rdx k59_106392_2 106370.Francci3_2818 1.58e-45 152.0 COG2193@1|root,COG2193@2|Bacteria,2GJEI@201174|Actinobacteria,4ESV8@85013|Frankiales 201174|Actinobacteria P Iron-storage protein, whose ferroxidase center binds Fe(2 ) ions, oxidizes them by dioxygen to Fe(3 ), and participates in the subsequent Fe(3 ) oxide mineral core formation within the central cavity of the protein complex bfr GO:0003674,GO:0003824,GO:0004322,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006873,GO:0006875,GO:0006879,GO:0008150,GO:0008152,GO:0009987,GO:0010035,GO:0010038,GO:0010039,GO:0016020,GO:0016491,GO:0016722,GO:0016724,GO:0019725,GO:0030003,GO:0033212,GO:0033214,GO:0042221,GO:0042592,GO:0044424,GO:0044444,GO:0044464,GO:0046916,GO:0048878,GO:0050801,GO:0050896,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0055114,GO:0065007,GO:0065008,GO:0071944,GO:0098771 1.16.3.1 ko:K03594 ko00860,map00860 - R00078 RC02758 ko00000,ko00001,ko01000 - - - Ferritin k59_276039_1 379066.GAU_3930 2.74e-42 148.0 COG5504@1|root,COG5504@2|Bacteria,1ZTCN@142182|Gemmatimonadetes 142182|Gemmatimonadetes O Zn-dependent protease - - - - - - - - - - - - - k59_552725_1 641526.ADIWIN_2908 1.33e-75 237.0 COG0519@1|root,COG0519@2|Bacteria,4NESX@976|Bacteroidetes,1HX9A@117743|Flavobacteriia 976|Bacteroidetes F Catalyzes the synthesis of GMP from XMP guaA GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046037,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 6.3.5.2 ko:K01951 ko00230,ko00983,ko01100,map00230,map00983,map01100 M00050 R01230,R01231,R08244 RC00010,RC00204 ko00000,ko00001,ko00002,ko01000,ko01002 - - - GATase,GMP_synt_C,NAD_synthase k59_552725_2 1137281.D778_02537 6.56e-33 127.0 COG0683@1|root,COG1388@1|root,COG0683@2|Bacteria,COG1388@2|Bacteria,4NG96@976|Bacteroidetes,1HY84@117743|Flavobacteriia 976|Bacteroidetes EM LysM domain lysM - - - - - - - - - - - ANF_receptor,LysM,Peripla_BP_6 k59_1794918_2 1121937.AUHJ01000006_gene2476 1.59e-37 136.0 COG0628@1|root,COG0628@2|Bacteria,1MW0B@1224|Proteobacteria,1RPVP@1236|Gammaproteobacteria,465AI@72275|Alteromonadaceae 1236|Gammaproteobacteria S permease perM GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944 - ko:K03548 - - - - ko00000,ko02000 2.A.86.1 - - AI-2E_transport k59_1458568_1 614083.AWQR01000033_gene2875 3.02e-20 92.8 COG0697@1|root,COG0697@2|Bacteria,1N3FA@1224|Proteobacteria,2VHAD@28216|Betaproteobacteria,4ABD4@80864|Comamonadaceae 28216|Betaproteobacteria EG Drug metabolite transporter cnrT - - - - - - - - - - - EamA k59_1288862_1 95619.PM1_0221270 3.01e-82 266.0 COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,1RMZ8@1236|Gammaproteobacteria 1236|Gammaproteobacteria I Involved in the aerobic and anaerobic degradation of long-chain fatty acids via beta-oxidation cycle. Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA. It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate fadJ - 1.1.1.35,4.2.1.17,5.1.2.3 ko:K01782 ko00071,ko00280,ko00281,ko00310,ko00362,ko00380,ko00410,ko00640,ko00650,ko00903,ko00930,ko01040,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00362,map00380,map00410,map00640,map00650,map00903,map00930,map01040,map01100,map01110,map01120,map01130,map01200,map01212 M00032,M00087 R01975,R03026,R03045,R03276,R04137,R04170,R04203,R04204,R04224,R04737,R04738,R04739,R04740,R04741,R04744,R04745,R04746,R04748,R04749,R05066,R05305,R06411,R06412,R06941,R06942,R07935,R07951,R08093,R08094 RC00029,RC00099,RC00117,RC00241,RC00525,RC00831,RC00834,RC00896,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 - - - 3HCDH,3HCDH_N,ECH_1 k59_1288862_2 95619.PM1_0221265 6.31e-131 383.0 COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,1RV50@1236|Gammaproteobacteria 1236|Gammaproteobacteria I Belongs to the thiolase family fadA - 2.3.1.16,2.3.1.9 ko:K00626,ko:K00632 ko00071,ko00072,ko00280,ko00281,ko00310,ko00362,ko00380,ko00592,ko00620,ko00630,ko00640,ko00642,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00281,map00310,map00362,map00380,map00592,map00620,map00630,map00640,map00642,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00087,M00088,M00095,M00113,M00373,M00374,M00375 R00238,R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095 RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N k59_1458573_1 94624.Bpet4165 7.89e-75 247.0 COG0243@1|root,COG0243@2|Bacteria,1NR6J@1224|Proteobacteria,2VHHZ@28216|Betaproteobacteria,3T57T@506|Alcaligenaceae 28216|Betaproteobacteria C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - - ko:K08351 ko00780,ko01100,map00780,map01100 - R10127 RC03056 ko00000,ko00001,ko01000,ko02000 5.A.3.4 - - Molybdopterin,Molydop_binding k59_667938_1 435591.BDI_2247 1.45e-46 171.0 COG0668@1|root,COG0668@2|Bacteria,4NFC6@976|Bacteroidetes,2FP31@200643|Bacteroidia,22Z43@171551|Porphyromonadaceae 976|Bacteroidetes M Mechanosensitive ion channel - - - - - - - - - - - - MS_channel k59_50405_1 946077.W5A_06113 2.03e-96 286.0 COG0357@1|root,COG0357@2|Bacteria,4NEJG@976|Bacteroidetes,1HYFU@117743|Flavobacteriia 976|Bacteroidetes J Specifically methylates the N7 position of a guanine in 16S rRNA rsmG GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036265,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070043,GO:0070475,GO:0070476,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.170 ko:K03501 - - - - ko00000,ko01000,ko03009,ko03036 - - - GidB k59_1577559_1 1117647.M5M_17820 3.11e-112 333.0 COG1181@1|root,COG1181@2|Bacteria,1MUTB@1224|Proteobacteria,1RMTM@1236|Gammaproteobacteria,1J4MW@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria F Belongs to the D-alanine--D-alanine ligase family ddl - 6.3.2.4 ko:K01921 ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502 - R01150 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Dala_Dala_lig_C,Dala_Dala_lig_N k59_615786_1 1316936.K678_00490 1.24e-82 262.0 COG1053@1|root,COG1053@2|Bacteria,1MU5M@1224|Proteobacteria,2U0QC@28211|Alphaproteobacteria,2JQ41@204441|Rhodospirillales 204441|Rhodospirillales C Fumarate reductase flavoprotein C-term - - - - - - - - - - - - FAD_binding_2,Succ_DH_flav_C k59_1685555_2 105559.Nwat_3074 3.43e-31 119.0 29CX4@1|root,2ZZV8@2|Bacteria,1RFY7@1224|Proteobacteria,1SBT1@1236|Gammaproteobacteria,1WYAZ@135613|Chromatiales 135613|Chromatiales S Domain of unknown function (DUF4390) - - - - - - - - - - - - DUF4390 k59_1519998_1 330214.NIDE4194 3.6e-65 204.0 COG2013@1|root,COG2013@2|Bacteria 2|Bacteria S Mitochondrial biogenesis AIM24 WQ51_05710 - - - - - - - - - - - AIM24 k59_276049_1 1229780.BN381_210085 2.85e-15 80.9 COG0739@1|root,COG0739@2|Bacteria,2HFQA@201174|Actinobacteria,3UWZQ@52018|unclassified Actinobacteria (class) 201174|Actinobacteria M Evidence 5 No homology to any previously reported sequences - - - - - - - - - - - - Peptidase_M23 k59_50410_1 1122194.AUHU01000005_gene828 4.38e-127 374.0 COG0015@1|root,COG0015@2|Bacteria,1MV4B@1224|Proteobacteria,1RN93@1236|Gammaproteobacteria,464G4@72275|Alteromonadaceae 1236|Gammaproteobacteria F Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily purB - 4.3.2.2 ko:K01756 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048,M00049 R01083,R04559 RC00379,RC00444,RC00445 ko00000,ko00001,ko00002,ko01000 - - - ASL_C,Lyase_1 k59_552759_1 1131266.ARWQ01000009_gene948 1.5e-10 64.7 COG3221@1|root,arCOG01805@2157|Archaea,41SWY@651137|Thaumarchaeota 651137|Thaumarchaeota P ABC transporter, phosphonate, periplasmic substrate-binding protein - - - ko:K02044 ko02010,map02010 M00223 - - ko00000,ko00001,ko00002,ko02000 3.A.1.9 - - Phosphonate-bd k59_1119599_1 502025.Hoch_5167 3.33e-90 275.0 COG0300@1|root,COG0300@2|Bacteria,1PG5S@1224|Proteobacteria,43473@68525|delta/epsilon subdivisions,2X263@28221|Deltaproteobacteria,2YXTC@29|Myxococcales 28221|Deltaproteobacteria S Enoyl-(Acyl carrier protein) reductase - - - - - - - - - - - - adh_short k59_106430_2 1211114.ALIP01000044_gene2043 5.97e-101 326.0 COG1297@1|root,COG1297@2|Bacteria,1N7SK@1224|Proteobacteria,1RNC8@1236|Gammaproteobacteria,1X4Q2@135614|Xanthomonadales 135614|Xanthomonadales S transporter oliA - - - - - - - - - - - OPT k59_497081_1 1026882.MAMP_01346 1.8e-89 276.0 COG2925@1|root,COG2925@2|Bacteria,1MV0U@1224|Proteobacteria,1RM85@1236|Gammaproteobacteria,4601T@72273|Thiotrichales 72273|Thiotrichales L Exonuclease C-terminal sbcB - 3.1.11.1 ko:K01141 ko03430,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - Exonuc_X-T_C,RNase_T k59_950922_1 1229909.NSED_06490 1.98e-81 267.0 COG0060@1|root,arCOG00807@2157|Archaea,41SFF@651137|Thaumarchaeota 651137|Thaumarchaeota J Belongs to the class-I aminoacyl-tRNA synthetase family - - 6.1.1.5 ko:K01870 ko00970,map00970 M00359,M00360 R03656 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,tRNA-synt_1 k59_219107_1 631362.Thi970DRAFT_02282 3.51e-20 94.4 COG5473@1|root,COG5473@2|Bacteria,1N9UJ@1224|Proteobacteria,1SZTB@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_730269_1 1248760.ANFZ01000011_gene283 7.59e-103 322.0 COG1048@1|root,COG1048@2|Bacteria,1MU9T@1224|Proteobacteria,2TT3T@28211|Alphaproteobacteria,2K0CP@204457|Sphingomonadales 204457|Sphingomonadales C Catalyzes the isomerization of citrate to isocitrate via cis-aconitate acnA - 4.2.1.3 ko:K01681 ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00173,M00740 R01324,R01325,R01900 RC00497,RC00498,RC00618 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase,Aconitase_C k59_219115_1 1101189.AQUO01000002_gene143 9.09e-14 69.7 COG2050@1|root,COG2050@2|Bacteria 2|Bacteria Q thiolester hydrolase activity - - - - - - - - - - - - 4HBT k59_219115_2 1121106.JQKB01000003_gene2530 1.48e-23 99.8 COG1473@1|root,COG1473@2|Bacteria,1MUIV@1224|Proteobacteria,2TR5B@28211|Alphaproteobacteria,2JPY3@204441|Rhodospirillales 204441|Rhodospirillales S Psort location Cytoplasmic, score 7.50 - - - - - - - - - - - - M20_dimer,Peptidase_M20 k59_730270_1 436308.Nmar_0011 6.71e-209 595.0 COG0464@1|root,arCOG01308@2157|Archaea,41SX8@651137|Thaumarchaeota 651137|Thaumarchaeota O Cell division protein 48 (CDC48), domain 2 - - - ko:K13525 ko04141,ko05134,map04141,map05134 M00400,M00403 - - ko00000,ko00001,ko00002,ko03019,ko04131,ko04147 3.A.16.1 - - AAA,CDC48_2,CDC48_N k59_334758_2 1122137.AQXF01000006_gene783 1.66e-62 192.0 COG0316@1|root,COG0316@2|Bacteria,1RHCW@1224|Proteobacteria,2UBR8@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Belongs to the HesB IscA family erpA - - ko:K13628,ko:K15724 - - - - ko00000,ko03016 - - - Fe-S_biosyn k59_839909_2 1415778.JQMM01000001_gene443 9.96e-63 207.0 COG0469@1|root,COG0469@2|Bacteria,1MU21@1224|Proteobacteria,1RMW3@1236|Gammaproteobacteria,1J5MU@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria G Pyruvate kinase, barrel domain pykF GO:0003674,GO:0003824,GO:0004743,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0016043,GO:0016052,GO:0016053,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0022607,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042802,GO:0042866,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0050896,GO:0051186,GO:0051188,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055086,GO:0065003,GO:0071704,GO:0071840,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576 2.7.1.40 ko:K00873 ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230 M00001,M00002,M00049,M00050 R00200,R00430,R01138,R01858,R02320 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - iECO103_1326.ECO103_1819,iPC815.YPO2393 PK,PK_C k59_1521041_2 1122137.AQXF01000001_gene3151 1.57e-93 296.0 COG1048@1|root,COG1048@2|Bacteria,1MU9T@1224|Proteobacteria,2TT3T@28211|Alphaproteobacteria 28211|Alphaproteobacteria C Catalyzes the isomerization of citrate to isocitrate via cis-aconitate acnA GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003730,GO:0003824,GO:0003994,GO:0005488,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017144,GO:0019541,GO:0019679,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0045333,GO:0046459,GO:0047456,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0071704,GO:0072350,GO:0097159,GO:1901363 4.2.1.3 ko:K01681 ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00173,M00740 R01324,R01325,R01900 RC00497,RC00498,RC00618 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase,Aconitase_C k59_1179561_1 672.VV93_v1c00020 3.61e-24 104.0 COG0592@1|root,COG0592@2|Bacteria,1MVD9@1224|Proteobacteria,1RMNP@1236|Gammaproteobacteria,1XSM8@135623|Vibrionales 135623|Vibrionales L Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria dnaN GO:0003674,GO:0003824,GO:0003887,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032991,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0042575,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0071897,GO:0090304,GO:0140097,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234 2.7.7.7 ko:K02338 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_beta,DNA_pol3_beta_2,DNA_pol3_beta_3 k59_219132_2 717785.HYPMC_4689 1.08e-20 88.6 COG0335@1|root,COG3743@1|root,COG0335@2|Bacteria,COG3743@2|Bacteria,1RH3A@1224|Proteobacteria,2U9DF@28211|Alphaproteobacteria,3N6WT@45401|Hyphomicrobiaceae 28211|Alphaproteobacteria J This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site rplS GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - ko:K02884 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L19 k59_1521061_1 1120746.CCNL01000008_gene631 3.56e-33 127.0 COG4992@1|root,COG4992@2|Bacteria 2|Bacteria E N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity patA GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006576,GO:0006595,GO:0006598,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008483,GO:0009056,GO:0009308,GO:0009310,GO:0009445,GO:0009447,GO:0009987,GO:0016740,GO:0016769,GO:0019842,GO:0030170,GO:0033094,GO:0034641,GO:0036094,GO:0042402,GO:0042802,GO:0043167,GO:0043168,GO:0044106,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0097159,GO:0097164,GO:1901363,GO:1901564,GO:1901565,GO:1901575 2.6.1.11,2.6.1.17,2.6.1.82 ko:K00821,ko:K05830,ko:K09251 ko00220,ko00300,ko00330,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map00330,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00028,M00031,M00763,M00845 R01155,R02283,R04475,R09778,R10932 RC00006,RC00062 ko00000,ko00001,ko00002,ko01000,ko01007 - - iECIAI1_1343.ECIAI1_3220,iECSF_1327.ECSF_2916,iECs_1301.ECs3955,iZ_1308.Z4426 Aminotran_3 k59_219137_1 1207058.L53_02915 1.38e-73 240.0 COG2223@1|root,COG2223@2|Bacteria,1R771@1224|Proteobacteria,2TWX5@28211|Alphaproteobacteria 28211|Alphaproteobacteria P Major facilitator Superfamily - - - - - - - - - - - - MFS_1 k59_1686754_1 1137799.GZ78_11880 5.92e-30 110.0 COG0848@1|root,COG0848@2|Bacteria,1RI4M@1224|Proteobacteria,1S4GX@1236|Gammaproteobacteria,1XKR8@135619|Oceanospirillales 135619|Oceanospirillales U Biopolymer - - - ko:K03559 - - - - ko00000,ko02000 1.A.30.2.1 - - ExbD k59_1686754_2 414684.RC1_0802 1.66e-16 74.7 COG0848@1|root,COG0848@2|Bacteria,1RI4M@1224|Proteobacteria,2VG9Y@28211|Alphaproteobacteria 28211|Alphaproteobacteria U Biopolymer transport protein ExbD/TolR - - - ko:K03559 - - - - ko00000,ko02000 1.A.30.2.1 - - ExbD k59_334786_1 316407.85674600 1.09e-50 161.0 28PF7@1|root,2ZC6G@2|Bacteria,1RA3M@1224|Proteobacteria,1S20M@1236|Gammaproteobacteria,3XPMI@561|Escherichia 1236|Gammaproteobacteria L Attenuates Hha toxicity and regulates biofilm formation. Binds to various coding and intergenic regions of genomic DNA tomB GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0008150,GO:0009987,GO:0042710,GO:0044010,GO:0044764,GO:0051704,GO:0097159,GO:1901363 - ko:K19162 - - - - ko00000,ko02048 - - - YbaJ k59_498118_1 556268.OFAG_00818 1.24e-17 82.4 COG0553@1|root,COG0553@2|Bacteria 2|Bacteria L helicase activity - - - - - - - - - - - - Helicase_C,SNF2_N k59_730287_1 1123503.KB908057_gene2647 1.47e-32 131.0 COG4774@1|root,COG4774@2|Bacteria,1QVG7@1224|Proteobacteria,2TV9I@28211|Alphaproteobacteria,2KG50@204458|Caulobacterales 204458|Caulobacterales P TonB-dependent receptor - - - - - - - - - - - - Plug,TonB_dep_Rec k59_1521074_1 498211.CJA_1507 1.49e-108 325.0 COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,1RMFF@1236|Gammaproteobacteria,1FGDF@10|Cellvibrio 1236|Gammaproteobacteria C Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain lpdG GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 1.8.1.4 ko:K00382 ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00036,M00307,M00532 R00209,R01221,R01698,R03815,R07618,R08549 RC00004,RC00022,RC00583,RC02742,RC02833,RC02834 br01601,ko00000,ko00001,ko00002,ko01000,ko04147 - - iE2348C_1286.E2348C_4372,iJN746.PP_4187 Pyr_redox_2,Pyr_redox_dim k59_51556_1 1229909.NSED_03245 8.11e-108 322.0 COG0644@1|root,arCOG00570@2157|Archaea,41S82@651137|Thaumarchaeota 651137|Thaumarchaeota C geranylgeranyl reductase - - 1.3.1.101,1.3.7.11 ko:K17830 ko00564,map00564 - R10325,R10326,R10331 RC03134 ko00000,ko00001,ko01000 - - - DAO,FAD_oxidored,Trp_halogenase k59_780363_1 1537715.JQFJ01000002_gene405 1.91e-16 77.8 COG5394@1|root,COG5394@2|Bacteria,1RHRC@1224|Proteobacteria,2TQWQ@28211|Alphaproteobacteria,2K0W5@204457|Sphingomonadales 204457|Sphingomonadales S synthesis repressor PhaR phaR - - - - - - - - - - - PHB_acc,PHB_acc_N k59_334806_1 1163617.SCD_n02200 4.41e-105 318.0 COG3267@1|root,COG3409@1|root,COG3267@2|Bacteria,COG3409@2|Bacteria,1MU3G@1224|Proteobacteria,2VIK1@28216|Betaproteobacteria 28216|Betaproteobacteria U SMART AAA ATPase exeA - - ko:K02450 - M00331 - - ko00000,ko00002,ko02044 9.B.42 - - AAA_22,PG_binding_1 k59_553921_1 1469557.JSWF01000025_gene1504 8e-07 52.4 COG0705@1|root,COG0705@2|Bacteria,4NGVJ@976|Bacteroidetes,1HZIN@117743|Flavobacteriia 976|Bacteroidetes S Rhomboid family - - - - - - - - - - - - Rhomboid k59_553921_2 443906.CMM_0263 1.43e-30 118.0 COG1181@1|root,COG1181@2|Bacteria,2GRWM@201174|Actinobacteria,4FRR6@85023|Microbacteriaceae 201174|Actinobacteria F Belongs to the D-alanine--D-alanine ligase family - - 6.3.2.4 ko:K01921 ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502 - R01150 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Dala_Dala_lig_C,Dala_Dala_lig_N k59_1459729_1 314225.ELI_04760 5.61e-145 431.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2TQS3@28211|Alphaproteobacteria,2K07A@204457|Sphingomonadales 204457|Sphingomonadales T signal transduction protein containing a membrane domain, an EAL and a GGDEF domain - - - - - - - - - - - - EAL,GGDEF,PAS_4,PAS_9,PilZ k59_1006609_1 1032480.MLP_48800 3.07e-53 177.0 COG1216@1|root,COG1216@2|Bacteria,2IDQX@201174|Actinobacteria 201174|Actinobacteria S Glycosyl transferase family 2 - - - - - - - - - - - - Glycos_transf_2 k59_392011_1 1713.JOFV01000004_gene3442 4.16e-05 48.1 COG0750@1|root,COG0750@2|Bacteria,2GJJT@201174|Actinobacteria,4F1WF@85016|Cellulomonadaceae 201174|Actinobacteria M Peptidase family M50 rip1 - - ko:K11749 ko02024,ko04112,map02024,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - PDZ_2,Peptidase_M50 k59_392014_1 1163617.SCD_n02491 4.06e-72 236.0 COG0768@1|root,COG0768@2|Bacteria,1MUNY@1224|Proteobacteria,2VIZM@28216|Betaproteobacteria 28216|Betaproteobacteria M Catalyzes cross-linking of the peptidoglycan cell wall at the division septum ftsI - 3.4.16.4 ko:K03587 ko00550,ko01501,map00550,map01501 - - - ko00000,ko00001,ko01000,ko01011,ko03036 - - - PBP_dimer,Transpeptidase k59_334820_1 1238182.C882_1622 1.42e-30 112.0 COG0745@1|root,COG0745@2|Bacteria,1RHCU@1224|Proteobacteria,2U98H@28211|Alphaproteobacteria,2JTBA@204441|Rhodospirillales 204441|Rhodospirillales T cheY-homologous receiver domain - - - - - - - - - - - - Response_reg k59_846987_1 660470.Theba_0827 2.38e-57 190.0 COG3842@1|root,COG3842@2|Bacteria,2GC81@200918|Thermotogae 200918|Thermotogae P ABC transporter - - - ko:K10112 ko02010,map02010 M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1 - - ABC_tran,TOBE k59_449811_1 1249627.D779_3250 5.1e-124 365.0 COG0162@1|root,COG0162@2|Bacteria,1MVUQ@1224|Proteobacteria,1RPKC@1236|Gammaproteobacteria,1WX6G@135613|Chromatiales 135613|Chromatiales J Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) tyrS - 6.1.1.1 ko:K01866 ko00970,map00970 M00359,M00360 R02918 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - S4,tRNA-synt_1b k59_1638325_1 1049564.TevJSym_ax00490 9.77e-71 241.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1J5F8@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria V AcrB/AcrD/AcrF family - - - - - - - - - - - - ACR_tran k59_1353083_1 1122603.ATVI01000011_gene2112 1.72e-32 127.0 COG1577@1|root,COG1577@2|Bacteria,1N400@1224|Proteobacteria,1SC29@1236|Gammaproteobacteria,1XAB2@135614|Xanthomonadales 135614|Xanthomonadales I GHMP kinases N terminal domain - - 2.7.4.2 ko:K00938 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00095 R03245 RC00002 ko00000,ko00001,ko00002,ko01000 - - - GHMP_kinases_N k59_1186136_1 436308.Nmar_1743 4.09e-11 61.6 arCOG10601@1|root,arCOG10601@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_1296964_1 862517.HMPREF9225_1577 7.1e-09 61.6 COG0497@1|root,COG0497@2|Bacteria,1V3MW@1239|Firmicutes,24HH8@186801|Clostridia,22IPZ@1570339|Peptoniphilaceae 186801|Clostridia L DNA recombination - - - - - - - - - - - - - k59_1693802_1 1713.JOFV01000004_gene3369 1.8e-47 156.0 COG0784@1|root,COG0784@2|Bacteria,2IFH8@201174|Actinobacteria,4F336@85016|Cellulomonadaceae 201174|Actinobacteria T cheY-homologous receiver domain rcp1 - - ko:K02485 - - - - ko00000,ko02022 - - - Response_reg k59_1693802_2 1173023.KE650771_gene2998 2.37e-05 47.8 COG0745@1|root,COG5000@1|root,COG0745@2|Bacteria,COG5000@2|Bacteria,1GPZW@1117|Cyanobacteria,1JI0S@1189|Stigonemataceae 1117|Cyanobacteria T Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) - - - - - - - - - - - - HATPase_c,HisKA,PAS,PAS_4,Response_reg k59_1242474_1 589865.DaAHT2_0963 3.04e-57 195.0 COG0188@1|root,COG0188@2|Bacteria,1MUGG@1224|Proteobacteria,42KZ9@68525|delta/epsilon subdivisions,2WJBC@28221|Deltaproteobacteria,2MIKT@213118|Desulfobacterales 28221|Deltaproteobacteria L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner - - - ko:K02621 - - - - ko00000,ko01000,ko02048,ko03032,ko03036 - - - DNA_topoisoIV k59_1242474_2 545694.TREPR_2445 2.41e-19 87.4 COG0187@1|root,COG0187@2|Bacteria,2J6PT@203691|Spirochaetes 203691|Spirochaetes L DNA topoisomerase parE - - ko:K02622 - - - - ko00000,ko01000,ko02048,ko03032,ko03036 - - - DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim k59_504942_1 521719.ATXQ01000001_gene382 5.23e-28 114.0 COG3287@1|root,COG3287@2|Bacteria,1MVUZ@1224|Proteobacteria,1RY7N@1236|Gammaproteobacteria,1YFJM@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria S FIST N domain - - - - - - - - - - - - FIST,FIST_C k59_168831_1 1122137.AQXF01000002_gene132 9.29e-177 526.0 COG0587@1|root,COG0587@2|Bacteria,1MUIF@1224|Proteobacteria,2TSCN@28211|Alphaproteobacteria 28211|Alphaproteobacteria L DNA polymerase III alpha subunit dnaE GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0050896,GO:0051716,GO:0071496 2.7.7.7 ko:K02337 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon k59_958036_1 1121403.AUCV01000010_gene1394 9.87e-72 228.0 COG0536@1|root,COG0536@2|Bacteria,1MUGZ@1224|Proteobacteria,42M40@68525|delta/epsilon subdivisions,2WIM4@28221|Deltaproteobacteria,2MI7D@213118|Desulfobacterales 28221|Deltaproteobacteria S An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control obg - - ko:K03979 - - - - ko00000,ko01000,ko03009 - - - GTP1_OBG,MMR_HSR1 k59_449864_1 316407.85676450 8.6e-123 384.0 COG3209@1|root,COG3209@2|Bacteria,1MVV1@1224|Proteobacteria,1SKYM@1236|Gammaproteobacteria,3XQSX@561|Escherichia 1236|Gammaproteobacteria M Rhs elements have a nonessential function. They may play an important role in the natural ecology of the cell rhsA GO:0006950,GO:0007154,GO:0008150,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0010438,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0042594,GO:0050896,GO:0051716,GO:0071496 - - - - - - - - - - DUF4329,Ntox34,RHS,RHS_repeat k59_847056_1 983544.Lacal_0958 9.2e-86 263.0 COG0389@1|root,COG0389@2|Bacteria,4NF1Y@976|Bacteroidetes,1HXHJ@117743|Flavobacteriia 976|Bacteroidetes L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII dinB - 2.7.7.7 ko:K02346 - - - - ko00000,ko01000,ko03400 - - - IMS,IMS_C,IMS_HHH k59_1242516_1 1026882.MAMP_01725 2.96e-24 105.0 COG0661@1|root,COG0661@2|Bacteria,1MU1Z@1224|Proteobacteria,1RNQM@1236|Gammaproteobacteria,45ZT8@72273|Thiotrichales 72273|Thiotrichales S Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis ubiB - - ko:K03688 - - - - ko00000 - - - ABC1 k59_1638405_1 760117.JN27_02145 4.17e-83 264.0 2DB7W@1|root,2Z7P1@2|Bacteria,1N65F@1224|Proteobacteria,2VK71@28216|Betaproteobacteria,476Q2@75682|Oxalobacteraceae 28216|Betaproteobacteria S Domain of unknown function (DUF4331) - - - - - - - - - - - - DUF4331 k59_168855_1 1137281.D778_00458 6.1e-86 283.0 COG1345@1|root,COG1361@1|root,COG3227@1|root,COG1345@2|Bacteria,COG1361@2|Bacteria,COG3227@2|Bacteria,4NMB8@976|Bacteroidetes 976|Bacteroidetes M Conserved repeat domain - - - - - - - - - - - - CHU_C,DUF11,He_PIG,Laminin_G_3,MAM k59_787384_1 314278.NB231_01958 1.58e-153 449.0 COG1344@1|root,COG1344@2|Bacteria,1MV1N@1224|Proteobacteria,1RN0Y@1236|Gammaproteobacteria,1WWGJ@135613|Chromatiales 135613|Chromatiales N Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella - - - ko:K02406 ko02020,ko02040,ko04621,ko04626,ko05132,ko05134,map02020,map02040,map04621,map04626,map05132,map05134 - - - ko00000,ko00001,ko02035 - - - Flagellin_C,Flagellin_IN,Flagellin_N k59_1638442_2 1112214.AHIS01000047_gene2191 3.65e-18 85.5 COG3104@1|root,COG3104@2|Bacteria,1MW6W@1224|Proteobacteria,2U15C@28211|Alphaproteobacteria,2K05X@204457|Sphingomonadales 204457|Sphingomonadales E amino acid peptide transporter - - - ko:K03305 - - - - ko00000 2.A.17 - - PTR2 k59_1242571_1 686340.Metal_0274 4.14e-21 92.8 COG1652@1|root,COG1652@2|Bacteria,1MUBV@1224|Proteobacteria,1RPMB@1236|Gammaproteobacteria,1XE9I@135618|Methylococcales 135618|Methylococcales S LysM domain - - - - - - - - - - - - LysM k59_1242571_2 1249627.D779_1361 3.44e-43 155.0 COG0758@1|root,COG0758@2|Bacteria,1MVF6@1224|Proteobacteria,1RPJE@1236|Gammaproteobacteria,1WWKX@135613|Chromatiales 135613|Chromatiales LU TIGRFAM DNA protecting protein DprA - - - ko:K04096 - - - - ko00000 - - - DNA_processg_A k59_507671_1 744980.TRICHSKD4_2855 5.56e-38 139.0 COG0345@1|root,COG0345@2|Bacteria,1R5J1@1224|Proteobacteria,2TTY7@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline proC GO:0003674,GO:0003824,GO:0004735,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016491,GO:0016645,GO:0016646,GO:0018130,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.5.1.2 ko:K00286 ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230 M00015 R01248,R01251,R03291,R03293 RC00054,RC00083 ko00000,ko00001,ko00002,ko01000 - - - F420_oxidored,P5CR_dimer k59_1016072_1 1122137.AQXF01000003_gene1903 9.58e-106 308.0 COG3820@1|root,COG3820@2|Bacteria,1MVR2@1224|Proteobacteria,2TT8Z@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Protein conserved in bacteria MA20_20925 - - ko:K09987 - - - - ko00000 - - - DUF1013 k59_1016072_2 1122137.AQXF01000003_gene1902 3.23e-130 378.0 COG0604@1|root,COG0604@2|Bacteria,1MX8A@1224|Proteobacteria,2TR1J@28211|Alphaproteobacteria 28211|Alphaproteobacteria C COG0604 NADPH quinone reductase and related Zn-dependent oxidoreductases - - 1.6.5.5 ko:K00344 - - - - ko00000,ko01000 - - - ADH_N,ADH_zinc_N,ADH_zinc_N_2 k59_789761_1 158500.BV97_00944 1.22e-21 87.4 COG0735@1|root,COG0735@2|Bacteria,1RDWJ@1224|Proteobacteria,2U6ZS@28211|Alphaproteobacteria,2K3Z2@204457|Sphingomonadales 204457|Sphingomonadales K Belongs to the Fur family fur - - ko:K03711 - - - - ko00000,ko03000 - - - FUR k59_789761_2 1096930.L284_23415 4.72e-90 265.0 COG4957@1|root,COG4957@2|Bacteria,1RGUW@1224|Proteobacteria,2U99M@28211|Alphaproteobacteria,2K4EY@204457|Sphingomonadales 204457|Sphingomonadales K Transcriptional regulator - - - - - - - - - - - - ROS_MUCR k59_789765_1 1500893.JQNB01000001_gene657 6.95e-52 176.0 COG3720@1|root,COG3720@2|Bacteria,1MW28@1224|Proteobacteria,1RP3D@1236|Gammaproteobacteria,1X6CT@135614|Xanthomonadales 135614|Xanthomonadales P Haem utilisation ChuX/HutX - - - ko:K07225 - - - - ko00000 - - - HemS k59_789785_1 396588.Tgr7_2271 6.96e-110 333.0 COG1530@1|root,COG1530@2|Bacteria,1MV65@1224|Proteobacteria,1RMIW@1236|Gammaproteobacteria,1WW9V@135613|Chromatiales 135613|Chromatiales J TIGRFAM ribonuclease, Rne Rng family - - - ko:K08301 - - - - ko00000,ko01000,ko03009,ko03019 - - - RNase_E_G,S1 k59_789817_1 1195246.AGRI_13271 3.89e-56 186.0 COG0142@1|root,COG0142@2|Bacteria,1MUK6@1224|Proteobacteria,1RPR7@1236|Gammaproteobacteria,4645T@72275|Alteromonadaceae 1236|Gammaproteobacteria H Belongs to the FPP GGPP synthase family ispB GO:0003674,GO:0003824,GO:0004659,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006066,GO:0006629,GO:0006720,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009108,GO:0009987,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0042180,GO:0042181,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901615,GO:1901617,GO:1901661,GO:1901663 2.5.1.90 ko:K02523 ko00900,ko01110,map00900,map01110 - R09248 RC00279 ko00000,ko00001,ko01000,ko01006 - - iYL1228.KPN_03597,ic_1306.c3945 polyprenyl_synt k59_1355443_1 343509.SG1059 3.93e-83 257.0 COG0331@1|root,COG0331@2|Bacteria,1MV6N@1224|Proteobacteria,1RNH3@1236|Gammaproteobacteria 1236|Gammaproteobacteria I malonyl CoA-acyl carrier protein transacylase fabD GO:0003674,GO:0003824,GO:0004312,GO:0004314,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016417,GO:0016419,GO:0016420,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0072330,GO:1901576 2.3.1.39 ko:K00645 ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212 M00082 R01626,R11671 RC00004,RC00039,RC02727 ko00000,ko00001,ko00002,ko01000,ko01004 - - iEcE24377_1341.EcE24377A_1213,iJN746.PP_1913,iPC815.YPO1598 Acyl_transf_1 k59_789850_1 247633.GP2143_09080 3.3e-69 228.0 COG0471@1|root,COG0471@2|Bacteria,1MU0K@1224|Proteobacteria,1RMI1@1236|Gammaproteobacteria,1J4XJ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P COG0471 Di- and tricarboxylate transporters - - - - - - - - - - - - CitMHS,TrkA_C k59_563907_1 1120956.JHZK01000009_gene1649 1.46e-315 870.0 COG0367@1|root,COG0367@2|Bacteria,1MW4E@1224|Proteobacteria,2TSCY@28211|Alphaproteobacteria,1JNP7@119043|Rhodobiaceae 28211|Alphaproteobacteria E Asparagine synthase asnO - 6.3.5.4 ko:K01953 ko00250,ko01100,ko01110,map00250,map01100,map01110 - R00578 RC00010 ko00000,ko00001,ko01000,ko01002 - - - Asn_synthase,GATase_7 k59_563907_2 1120956.JHZK01000009_gene1648 5.21e-222 632.0 COG0189@1|root,COG0454@1|root,COG0189@2|Bacteria,COG0456@2|Bacteria,1MVN2@1224|Proteobacteria,2TUT9@28211|Alphaproteobacteria,1JNC5@119043|Rhodobiaceae 28211|Alphaproteobacteria HJK Prokaryotic glutathione synthetase, ATP-grasp domain cphA - - - - - - - - - - - Acetyltransf_1,Dala_Dala_lig_C,GSH-S_ATP,RimK k59_1355475_1 1049564.TevJSym_aa01890 6.8e-65 214.0 COG0699@1|root,COG0699@2|Bacteria,1MV59@1224|Proteobacteria,1RYGW@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Dynamin family - - - - - - - - - - - - Dynamin_N k59_789873_1 377629.TERTU_3794 1.76e-82 251.0 COG1099@1|root,COG1099@2|Bacteria,1MY2H@1224|Proteobacteria,1RTX9@1236|Gammaproteobacteria,2PMJ7@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria S TatD related DNase - - - ko:K07051 - - - - ko00000 - - - TatD_DNase k59_1016213_1 4006.Lus10023224 1.1e-06 52.8 COG1022@1|root,KOG1256@2759|Eukaryota,37QW0@33090|Viridiplantae,3GEUP@35493|Streptophyta,4JG3R@91835|fabids 35493|Streptophyta I acyl-activating enzyme 16 AAE15 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0008922,GO:0009058,GO:0009507,GO:0009526,GO:0009536,GO:0009941,GO:0009987,GO:0015645,GO:0016053,GO:0016874,GO:0016877,GO:0016878,GO:0019752,GO:0030497,GO:0031967,GO:0031975,GO:0032787,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0046394,GO:0071704,GO:0072330,GO:1901576 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding k59_1016213_2 1122137.AQXF01000003_gene2255 1.47e-190 541.0 COG0577@1|root,COG0577@2|Bacteria,1PBKH@1224|Proteobacteria,2TW3U@28211|Alphaproteobacteria 28211|Alphaproteobacteria V ABC-type antimicrobial peptide transport system, permease component - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_1016213_3 1303518.CCALI_01463 9.75e-29 110.0 COG1136@1|root,COG1136@2|Bacteria 2|Bacteria V lipoprotein transporter activity macB - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_563960_1 713587.THITH_13715 5.96e-73 236.0 COG4943@1|root,COG4943@2|Bacteria,1QTUY@1224|Proteobacteria,1T494@1236|Gammaproteobacteria,1X2UR@135613|Chromatiales 135613|Chromatiales T CSS motif domain associated with EAL - - - - - - - - - - - - CSS-motif,EAL k59_1016236_1 1137799.GZ78_26585 7.89e-40 144.0 COG4638@1|root,COG4638@2|Bacteria,1MWXW@1224|Proteobacteria,1RQ0P@1236|Gammaproteobacteria,1XI6D@135619|Oceanospirillales 135619|Oceanospirillales P Rieske 2Fe-2S - - - - - - - - - - - - Rieske,Ring_hydroxyl_A k59_1355506_1 247634.GPB2148_686 2.55e-76 247.0 COG0021@1|root,COG0021@2|Bacteria,1MUEY@1224|Proteobacteria,1RMWP@1236|Gammaproteobacteria,1J4RR@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria G Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate tkt - 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 - - - Transket_pyr,Transketolase_C,Transketolase_N k59_1355506_2 1415778.JQMM01000001_gene460 4.63e-109 323.0 COG0057@1|root,COG0057@2|Bacteria,1MU93@1224|Proteobacteria,1RMBM@1236|Gammaproteobacteria,1J58Q@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria G Belongs to the glyceraldehyde-3-phosphate dehydrogenase family epd GO:0000166,GO:0003674,GO:0003824,GO:0004365,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006081,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008614,GO:0008615,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0016491,GO:0016620,GO:0016903,GO:0017144,GO:0018130,GO:0019318,GO:0019438,GO:0019637,GO:0034641,GO:0036094,GO:0042364,GO:0042816,GO:0042819,GO:0042822,GO:0042823,GO:0043891,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046184,GO:0046483,GO:0048001,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0051287,GO:0055114,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 1.2.1.12,1.2.1.72 ko:K00134,ko:K03472 ko00010,ko00710,ko00750,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map00750,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010 M00001,M00002,M00003,M00124,M00165,M00166,M00308,M00552 R01061,R01825 RC00149,RC00242 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - iYL1228.KPN_03356 Gp_dh_C,Gp_dh_N k59_789915_1 1401065.HMPREF2130_07375 9.32e-26 110.0 COG1034@1|root,COG1034@2|Bacteria,1P8MN@1224|Proteobacteria,2VJYV@28216|Betaproteobacteria,3T1EQ@506|Alcaligenaceae 28216|Betaproteobacteria C Catalyzes the transfer of electrons from NADH to ubiquinone nuoG - 1.6.5.3 ko:K00336 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Fer2_4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3 k59_1016257_1 869210.Marky_0810 9.61e-08 55.8 COG0334@1|root,COG0334@2|Bacteria,1WIN6@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus E Belongs to the Glu Leu Phe Val dehydrogenases family - - 1.4.1.3 ko:K00261 ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964 M00740 R00243,R00248 RC00006,RC02799 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ELFV_dehydrog,ELFV_dehydrog_N k59_1016258_1 1236959.BAMT01000004_gene903 1.95e-09 58.2 2E2GR@1|root,32XKS@2|Bacteria,1N41X@1224|Proteobacteria,2VUN3@28216|Betaproteobacteria,2KKWG@206350|Nitrosomonadales 206350|Nitrosomonadales S Domain of unknown function (DUF4340) - - - - - - - - - - - - DUF4340 k59_1016258_2 335283.Neut_2511 6.65e-31 120.0 COG3225@1|root,COG3225@2|Bacteria,1MUXW@1224|Proteobacteria,2VMDE@28216|Betaproteobacteria,37263@32003|Nitrosomonadales 28216|Betaproteobacteria N ABC-type uncharacterized transport system - - - - - - - - - - - - ABC_transp_aux k59_1016260_1 1122137.AQXF01000003_gene2435 5.1e-100 308.0 COG0038@1|root,COG0038@2|Bacteria,1MV4K@1224|Proteobacteria,2TTBG@28211|Alphaproteobacteria 28211|Alphaproteobacteria P Chloride channel clcA - - ko:K03281 - - - - ko00000 2.A.49 - - Voltage_CLC k59_1355523_1 926567.TheveDRAFT_0387 6.8e-78 248.0 COG2801@1|root,COG2801@2|Bacteria,3TCBG@508458|Synergistetes 508458|Synergistetes L Integrase core domain - - - - - - - - - - - - rve k59_564010_1 1122137.AQXF01000002_gene513 1.06e-10 62.4 COG0665@1|root,COG4121@1|root,COG0665@2|Bacteria,COG4121@2|Bacteria,1MZW5@1224|Proteobacteria,2TUNX@28211|Alphaproteobacteria 28211|Alphaproteobacteria J Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 mnmC - 2.1.1.61 ko:K15461 - - R00601,R08702 RC00003,RC00053,RC00060,RC01483 ko00000,ko01000,ko03016 - - - DAO,Methyltransf_30 k59_564010_2 314256.OG2516_03373 2.57e-42 143.0 COG0663@1|root,COG0663@2|Bacteria,1RD76@1224|Proteobacteria,2U5GR@28211|Alphaproteobacteria,2PD02@252301|Oceanicola 28211|Alphaproteobacteria S Hexapeptide repeat of succinyl-transferase dapH - - - - - - - - - - - Hexapep k59_789952_1 1149133.ppKF707_2868 4.32e-32 129.0 COG0784@1|root,COG4191@1|root,COG0784@2|Bacteria,COG4191@2|Bacteria,1QTVB@1224|Proteobacteria,1RYDJ@1236|Gammaproteobacteria,1YCRZ@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria T PAS fold pedS1 - 2.7.13.3 ko:K20975 ko02020,ko02025,map02020,map02025 M00820 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA,PAS_4,PAS_7,PAS_8,Response_reg k59_564020_1 641524.ADICYQ_4021 2.27e-25 105.0 COG3540@1|root,COG3540@2|Bacteria,4NDUS@976|Bacteroidetes,47NKM@768503|Cytophagia 976|Bacteroidetes P PhoD-like phosphatase - - 3.1.3.1 ko:K01113 ko00790,ko01100,ko02020,map00790,map01100,map02020 M00126 R04620 RC00017 ko00000,ko00001,ko00002,ko01000 - - - PhoD k59_507931_1 323848.Nmul_A2683 8.2e-65 216.0 COG4232@1|root,COG4232@2|Bacteria,1MU8W@1224|Proteobacteria,2VI8I@28216|Betaproteobacteria,371ZZ@32003|Nitrosomonadales 28216|Betaproteobacteria CO Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps dsbD - 1.8.1.8 ko:K04084 - - - - ko00000,ko01000,ko03110 5.A.1.1 - - DsbC,DsbD,Thioredoxin_2,Thioredoxin_7 k59_1016307_1 1038860.AXAP01000122_gene3283 3.91e-103 304.0 COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,1MW8A@1224|Proteobacteria,2UQQJ@28211|Alphaproteobacteria 28211|Alphaproteobacteria L DDE superfamily endonuclease - - - - - - - - - - - - DDE_3,HTH_32,HTH_33 k59_1016335_1 1408473.JHXO01000008_gene2724 9.21e-52 180.0 COG0477@1|root,COG2814@2|Bacteria,4NG27@976|Bacteroidetes,2FNG3@200643|Bacteroidia 976|Bacteroidetes P major facilitator superfamily - - - ko:K03446 - M00701 - - ko00000,ko00002,ko02000 2.A.1.3 - - MFS_1 k59_1016341_1 525909.Afer_0346 1.96e-15 77.0 COG2345@1|root,COG2345@2|Bacteria 2|Bacteria K Transcriptional regulator - - - - - - - - - - - - HTH_20 k59_1805814_1 1121937.AUHJ01000003_gene3325 5.38e-100 319.0 COG1014@1|root,COG4231@1|root,COG1014@2|Bacteria,COG4231@2|Bacteria,1MUKS@1224|Proteobacteria,1RSEQ@1236|Gammaproteobacteria,465RF@72275|Alteromonadaceae 1236|Gammaproteobacteria C Pyruvate ferredoxin/flavodoxin oxidoreductase iorA - 1.2.7.8 ko:K04090 - - - - br01601,ko00000,ko01000 - - - POR,TPP_enzyme_C k59_507981_1 1122951.ATUE01000006_gene1216 7.73e-30 128.0 COG2267@1|root,COG2267@2|Bacteria,1MX2H@1224|Proteobacteria,1RRSX@1236|Gammaproteobacteria 1236|Gammaproteobacteria M serine threonine protein kinase IV02_22745 - - - - - - - - - - - - k59_564110_1 443906.CMM_2605 1.33e-36 129.0 COG0094@1|root,COG0094@2|Bacteria,2GJW7@201174|Actinobacteria,4FKHV@85023|Microbacteriaceae 201174|Actinobacteria J This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits rplE GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02931 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L5,Ribosomal_L5_C k59_564110_2 525909.Afer_0409 4.27e-32 115.0 COG0198@1|root,COG0198@2|Bacteria,2HGDN@201174|Actinobacteria,4CNBW@84992|Acidimicrobiia 84992|Acidimicrobiia J One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit rplX - - ko:K02895 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - KOW,ribosomal_L24 k59_564110_3 31964.CMS0293 2.09e-66 203.0 COG0093@1|root,COG0093@2|Bacteria,2IHNX@201174|Actinobacteria,4FNQS@85023|Microbacteriaceae 201174|Actinobacteria J Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome rplN GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0008150,GO:0015934,GO:0016020,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070180,GO:0071944,GO:0097159,GO:1901363,GO:1990904 - ko:K02874 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L14 k59_564110_4 457424.BFAG_04316 1.63e-27 102.0 COG0186@1|root,COG0186@2|Bacteria,4NSB2@976|Bacteroidetes,2FTXY@200643|Bacteroidia,4AR99@815|Bacteroidaceae 976|Bacteroidetes J One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA rpsQ GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02961 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S17 k59_564117_1 266117.Rxyl_0063 1.32e-32 123.0 arCOG10178@1|root,2ZAAA@2|Bacteria 2|Bacteria S PFAM CAAX amino terminal protease family - - - - - - - - - - - - Abi k59_508041_1 1122137.AQXF01000003_gene1872 9.67e-135 393.0 COG2972@1|root,COG2972@2|Bacteria,1MXVQ@1224|Proteobacteria,2U16F@28211|Alphaproteobacteria 28211|Alphaproteobacteria T Histidine kinase - - - - - - - - - - - - HATPase_c,His_kinase,PocR k59_508041_2 1122137.AQXF01000003_gene1873 1.01e-51 170.0 COG3279@1|root,COG3279@2|Bacteria,1MUE8@1224|Proteobacteria,2TSPC@28211|Alphaproteobacteria 28211|Alphaproteobacteria T Response regulator of the LytR AlgR family - - - ko:K02477 - - - - ko00000,ko02022 - - - LytTR,Response_reg k59_1805864_1 426117.M446_3989 3.49e-69 229.0 COG0438@1|root,COG0438@2|Bacteria,1RI8C@1224|Proteobacteria,2UIQP@28211|Alphaproteobacteria,1JTI9@119045|Methylobacteriaceae 28211|Alphaproteobacteria M Glycosyl transferases group 1 - - - - - - - - - - - - Capsule_synth,Glyco_trans_1_4 k59_687318_1 1229909.NSED_06250 3.89e-09 54.3 arCOG10955@1|root,arCOG10955@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_1082887_1 497321.C664_17822 8.63e-05 44.7 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2VHSB@28216|Betaproteobacteria,2KU97@206389|Rhodocyclales 206389|Rhodocyclales T COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains - - - - - - - - - - - - HTH_8,Response_reg,Sigma54_activat k59_1082887_2 709797.CSIRO_1376 1.51e-14 68.6 2E7PS@1|root,3325B@2|Bacteria,1N7R7@1224|Proteobacteria,2UFCM@28211|Alphaproteobacteria,3K0ZR@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S Evidence 4 Homologs of previously reported genes of - - - - - - - - - - - - - k59_1082887_3 2340.JV46_12870 7.03e-34 127.0 COG1910@1|root,COG1910@2|Bacteria,1MVS4@1224|Proteobacteria,1RY8Q@1236|Gammaproteobacteria,1JB29@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P Helix-turn-helix domain - - - - - - - - - - - - HTH_17,PBP_like k59_404932_1 1088721.NSU_3638 1.85e-87 285.0 COG3250@1|root,COG3250@2|Bacteria,1P9KJ@1224|Proteobacteria,2UZ0A@28211|Alphaproteobacteria,2K315@204457|Sphingomonadales 204457|Sphingomonadales G alpha-L-rhamnosidase - - - - - - - - - - - - Glyco_hydro_106 k59_292485_1 177437.HRM2_11190 2.04e-45 158.0 COG0774@1|root,COG0774@2|Bacteria,1MV6T@1224|Proteobacteria,42MVM@68525|delta/epsilon subdivisions,2WJ4I@28221|Deltaproteobacteria,2MHWY@213118|Desulfobacterales 28221|Deltaproteobacteria M Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis lpxC - 3.5.1.108 ko:K02535,ko:K13599 ko00540,ko01100,ko02020,map00540,map01100,map02020 M00060,M00498 R04587 RC00166,RC00300 ko00000,ko00001,ko00002,ko01000,ko01005,ko02022 - - - LpxC k59_630813_1 1163617.SCD_n02621 3.17e-53 177.0 COG0462@1|root,COG0462@2|Bacteria,1MW21@1224|Proteobacteria,2VHU0@28216|Betaproteobacteria 28216|Betaproteobacteria F Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) prs - 2.7.6.1 ko:K00948 ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230 M00005 R01049 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - Pribosyl_synth,Pribosyltran_N k59_630813_2 1517416.IDAT_07800 6.35e-37 131.0 COG1825@1|root,COG1825@2|Bacteria,1RDH0@1224|Proteobacteria,1S46A@1236|Gammaproteobacteria,2QF1H@267893|Idiomarinaceae 1236|Gammaproteobacteria J This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance ctc GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02897 ko03010,map03010 M00178 - - ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L25p,Ribosomal_TL5_C k59_1590947_1 357808.RoseRS_3131 8.14e-47 169.0 COG3903@1|root,COG3903@2|Bacteria,2G8KB@200795|Chloroflexi 200795|Chloroflexi K NB-ARC domain protein - - - - - - - - - - - - HTH_3,HTH_31,NB-ARC,TPR_12 k59_123716_2 1229909.NSED_00015 3.51e-170 478.0 COG0648@1|root,arCOG01894@2157|Archaea,41SDW@651137|Thaumarchaeota 651137|Thaumarchaeota L Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin nfo - 3.1.21.2 ko:K01151 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - AP_endonuc_2 k59_123716_3 1229909.NSED_00020 2.74e-198 555.0 COG2219@1|root,arCOG03013@2157|Archaea,41SCD@651137|Thaumarchaeota 651137|Thaumarchaeota L Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair priL - - ko:K18882 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - DNA_primase_lrg k59_123716_4 1229909.NSED_00025 8.17e-128 373.0 COG1467@1|root,arCOG04110@2157|Archaea,41SCB@651137|Thaumarchaeota 651137|Thaumarchaeota L Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair priS - - ko:K02683 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - DNA_primase_S k59_462497_2 997346.HMPREF9374_3746 8.61e-11 63.9 COG4948@1|root,COG4948@2|Bacteria,1TQMS@1239|Firmicutes,4HBMX@91061|Bacilli,27CMB@186824|Thermoactinomycetaceae 91061|Bacilli H Mandelate racemase / muconate lactonizing enzyme, C-terminal domain menC - 4.2.1.113 ko:K02549 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116 R04031 RC01053 ko00000,ko00001,ko00002,ko01000 - - - MR_MLE_C,MR_MLE_N k59_179960_1 933262.AXAM01000033_gene1627 1.49e-65 211.0 COG0123@1|root,COG0123@2|Bacteria,1MU7P@1224|Proteobacteria,42NQP@68525|delta/epsilon subdivisions,2WIQD@28221|Deltaproteobacteria,2MJGP@213118|Desulfobacterales 28221|Deltaproteobacteria BQ PFAM Histone deacetylase - - - - - - - - - - - - Hist_deacetyl k59_631793_1 566466.NOR53_188 3.19e-63 211.0 COG3186@1|root,COG3186@2|Bacteria,1MU29@1224|Proteobacteria,1RQBJ@1236|Gammaproteobacteria,1J73K@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C COG3186 Phenylalanine-4-hydroxylase phhA GO:0003674,GO:0003824,GO:0004497,GO:0004505,GO:0006082,GO:0006520,GO:0006558,GO:0006559,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009072,GO:0009074,GO:0009987,GO:0016054,GO:0016491,GO:0016705,GO:0016714,GO:0017144,GO:0019439,GO:0019752,GO:0042737,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0055114,GO:0071704,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606,GO:1902221,GO:1902222 1.14.16.1 ko:K00500 ko00360,ko00400,ko00790,ko01100,ko01230,map00360,map00400,map00790,map01100,map01230 - R01795,R07211 RC00490 ko00000,ko00001,ko01000 - - - Biopterin_H k59_349975_2 502025.Hoch_0522 1.36e-34 130.0 COG2304@1|root,COG2304@2|Bacteria,1MXQ7@1224|Proteobacteria,42NWB@68525|delta/epsilon subdivisions,2WKKE@28221|Deltaproteobacteria,2YXC9@29|Myxococcales 28221|Deltaproteobacteria S protein containing a von Willebrand factor type A (vWA) domain batA - - ko:K07114 - - - - ko00000,ko02000 1.A.13.2.2,1.A.13.2.3 - - BatA,VWA k59_1648879_1 1122137.AQXF01000001_gene3025 1.46e-229 643.0 COG0195@1|root,COG0195@2|Bacteria,1MWT7@1224|Proteobacteria,2TRQN@28211|Alphaproteobacteria 28211|Alphaproteobacteria K Participates in both transcription termination and antitermination nusA - - ko:K02600 - - - - ko00000,ko03009,ko03021 - - - HHH_5,KH_5,NusA_N,S1 k59_1028268_1 748247.AZKH_1458 1.46e-78 247.0 COG0009@1|root,COG0009@2|Bacteria,1MVPM@1224|Proteobacteria,2VIFT@28216|Betaproteobacteria,2KUUI@206389|Rhodocyclales 206389|Rhodocyclales J Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine sua5 - 2.7.7.87 ko:K07566 - - R10463 RC00745 ko00000,ko01000,ko03009,ko03016 - - - SUA5,Sua5_yciO_yrdC k59_462513_1 555793.WSK_2178 1.1e-37 132.0 COG1280@1|root,COG1280@2|Bacteria,1MXAI@1224|Proteobacteria,2U8MN@28211|Alphaproteobacteria,2KCSI@204457|Sphingomonadales 204457|Sphingomonadales E threonine efflux protein - - - - - - - - - - - - LysE k59_744862_1 909613.UO65_1751 1.2e-07 53.1 COG0638@1|root,COG0638@2|Bacteria,2GJ60@201174|Actinobacteria,4DY60@85010|Pseudonocardiales 201174|Actinobacteria O Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation prcB GO:0000502,GO:0003674,GO:0003824,GO:0004175,GO:0004298,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005839,GO:0005886,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009405,GO:0009987,GO:0010498,GO:0016020,GO:0016787,GO:0019538,GO:0019774,GO:0019899,GO:0019941,GO:0030163,GO:0032991,GO:0035375,GO:0040007,GO:0043170,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044419,GO:0044424,GO:0044464,GO:0051603,GO:0051704,GO:0070003,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1905368,GO:1905369 3.4.25.1 ko:K03433 ko03050,map03050 M00342,M00343 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03051 - - - Proteasome k59_744862_2 710696.Intca_1771 7.25e-66 210.0 COG0638@1|root,COG0638@2|Bacteria,2GKZ1@201174|Actinobacteria,4FFJS@85021|Intrasporangiaceae 201174|Actinobacteria O Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation prcA GO:0000502,GO:0003674,GO:0003824,GO:0004175,GO:0004298,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005839,GO:0005886,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009405,GO:0009987,GO:0010498,GO:0016020,GO:0016787,GO:0019538,GO:0019773,GO:0019941,GO:0030163,GO:0030312,GO:0032991,GO:0040007,GO:0043170,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044419,GO:0044424,GO:0044464,GO:0051603,GO:0051704,GO:0070003,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1905368,GO:1905369 3.4.25.1 ko:K03432 ko03050,map03050 M00342,M00343 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03051 - - - Proteasome k59_1535930_1 436308.Nmar_1385 2.18e-55 183.0 COG0731@1|root,arCOG00953@2157|Archaea 2157|Archaea C Radical SAM domain protein rlmN - 2.1.1.192 ko:K06941 - - - - ko00000,ko01000,ko03009 - - - Fer4_14,Radical_SAM k59_1535930_2 1229909.NSED_03375 3.23e-39 143.0 COG0008@1|root,arCOG00402@2157|Archaea,41SFI@651137|Thaumarchaeota 651137|Thaumarchaeota J Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) proS - 6.1.1.15 ko:K01881 ko00970,map00970 M00359,M00360 R03661 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,ProRS-C_1,tRNA-synt_2b k59_1197010_1 1122612.AUBA01000017_gene2689 1.17e-06 50.4 COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,2TRYI@28211|Alphaproteobacteria,2K0VP@204457|Sphingomonadales 204457|Sphingomonadales C FAD linked - - - - - - - - - - - - FAD-oxidase_C,FAD_binding_4 k59_1197010_2 926550.CLDAP_38230 4.49e-42 148.0 COG1171@1|root,COG1171@2|Bacteria,2G69F@200795|Chloroflexi 200795|Chloroflexi E PFAM Pyridoxal-5'-phosphate-dependent protein beta subunit ilvA - 4.3.1.19 ko:K01754 ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230 M00570 R00220,R00996 RC00418,RC02600 ko00000,ko00001,ko00002,ko01000 - - - PALP,Thr_dehydrat_C k59_1140266_1 768671.ThimaDRAFT_3401 5.8e-70 223.0 2CB8R@1|root,2Z90U@2|Bacteria,1R4DV@1224|Proteobacteria,1RPSZ@1236|Gammaproteobacteria,1WZX3@135613|Chromatiales 135613|Chromatiales - - - - - - - - - - - - - - - k59_1648905_1 1229909.NSED_09315 7.21e-16 71.2 arCOG08679@1|root,arCOG08679@2157|Archaea 2157|Archaea S zinc finger - - - - - - - - - - - - - k59_1028291_1 1230343.CANP01000046_gene3647 4.09e-64 212.0 COG0827@1|root,COG0827@2|Bacteria,1QYXX@1224|Proteobacteria,1SKI5@1236|Gammaproteobacteria 1236|Gammaproteobacteria L DNA restriction-modification system - - - - - - - - - - - - - k59_1197038_1 279714.FuraDRAFT_2687 9.3e-90 275.0 COG0849@1|root,COG0849@2|Bacteria,1MUSR@1224|Proteobacteria,2VGZP@28216|Betaproteobacteria,2KPVY@206351|Neisseriales 206351|Neisseriales D Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring ftsA - - ko:K03590 ko04112,map04112 - - - ko00000,ko00001,ko03036,ko04812 - - - FtsA,SHS2_FTSA k59_970430_2 1056512.D515_02405 1.33e-54 180.0 COG2313@1|root,COG2313@2|Bacteria,1MUQU@1224|Proteobacteria,1RQJH@1236|Gammaproteobacteria,1XSEM@135623|Vibrionales 135623|Vibrionales Q Catalyzes the reversible cleavage of pseudouridine 5'- phosphate (PsiMP) to ribose 5-phosphate and uracil. Functions biologically in the cleavage direction, as part of a pseudouridine degradation pathway psuG - 4.2.1.70 ko:K16329 ko00240,map00240 - R01055 RC00432,RC00433 ko00000,ko00001,ko01000 - - - Indigoidine_A k59_914400_1 1122137.AQXF01000001_gene3151 2.11e-150 448.0 COG1048@1|root,COG1048@2|Bacteria,1MU9T@1224|Proteobacteria,2TT3T@28211|Alphaproteobacteria 28211|Alphaproteobacteria C Catalyzes the isomerization of citrate to isocitrate via cis-aconitate acnA GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003730,GO:0003824,GO:0003994,GO:0005488,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017144,GO:0019541,GO:0019679,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0045333,GO:0046459,GO:0047456,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0071704,GO:0072350,GO:0097159,GO:1901363 4.2.1.3 ko:K01681 ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00173,M00740 R01324,R01325,R01900 RC00497,RC00498,RC00618 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase,Aconitase_C k59_1705196_1 1380356.JNIK01000002_gene4785 6.86e-33 127.0 28HG7@1|root,2Z7S3@2|Bacteria,2GMJK@201174|Actinobacteria 201174|Actinobacteria S Pfam Wyosine base formation - - - - - - - - - - - - MDMPI_N,Wyosine_form k59_1705196_2 756883.Halar_2656 6.59e-23 95.5 COG0434@1|root,arCOG01982@2157|Archaea 2157|Archaea S photosystem I assembly BtpA - - - ko:K06971 - - - - ko00000 - - - BtpA k59_801866_1 502025.Hoch_4481 3.58e-95 290.0 COG0065@1|root,COG0065@2|Bacteria,1MVYR@1224|Proteobacteria,42M5D@68525|delta/epsilon subdivisions,2WJ59@28221|Deltaproteobacteria,2YU3W@29|Myxococcales 28221|Deltaproteobacteria H Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate leuC - 4.2.1.33,4.2.1.35 ko:K01703 ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230 M00432,M00535 R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170 RC00497,RC00976,RC00977,RC01041,RC01046,RC03072 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase k59_1705201_1 1123270.ATUR01000006_gene194 3.99e-147 430.0 COG0318@1|root,COG0318@2|Bacteria,1NTR7@1224|Proteobacteria,2UPRR@28211|Alphaproteobacteria,2K3JS@204457|Sphingomonadales 204457|Sphingomonadales IQ AMP-binding enzyme - - - ko:K00666 - - - - ko00000,ko01000,ko01004 - - - AMP-binding,AMP-binding_C k59_688440_1 1232410.KI421418_gene2408 1.67e-49 184.0 COG3507@1|root,COG4733@1|root,COG3507@2|Bacteria,COG4733@2|Bacteria,1RDH5@1224|Proteobacteria 1224|Proteobacteria G Protein of unknown function (DUF1349) - - - - - - - - - - - - DUF1349 k59_1366612_1 1255043.TVNIR_2240 2.94e-57 198.0 COG2225@1|root,COG2225@2|Bacteria,1MVEV@1224|Proteobacteria,1RPVI@1236|Gammaproteobacteria,1WXV7@135613|Chromatiales 135613|Chromatiales C Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA glcB - 2.3.3.9 ko:K01638 ko00620,ko00630,ko01100,ko01110,ko01120,ko01200,map00620,map00630,map01100,map01110,map01120,map01200 M00012 R00472 RC00004,RC00308,RC02747 ko00000,ko00001,ko00002,ko01000 - - - Malate_synthase k59_1310193_1 1380394.JADL01000005_gene5545 3.04e-152 438.0 COG1058@1|root,COG1058@2|Bacteria,1QUB2@1224|Proteobacteria 1224|Proteobacteria S Belongs to the CinA family yfaY - - - - - - - - - - - MoCF_biosynth k59_801873_1 338966.Ppro_3611 3.27e-83 264.0 COG0696@1|root,COG0696@2|Bacteria,1MUQ1@1224|Proteobacteria,42N6C@68525|delta/epsilon subdivisions,2WJ66@28221|Deltaproteobacteria,43T5X@69541|Desulfuromonadales 28221|Deltaproteobacteria G Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate gpmI - 5.4.2.12 ko:K15633 ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003 R01518 RC00536 ko00000,ko00001,ko00002,ko01000 - - - Metalloenzyme,Phosphodiest,iPGM_N k59_462548_1 1125863.JAFN01000001_gene3364 1.17e-101 319.0 COG1148@1|root,COG1148@2|Bacteria,1QUM4@1224|Proteobacteria,42MPP@68525|delta/epsilon subdivisions,2WJ3U@28221|Deltaproteobacteria 28221|Deltaproteobacteria C 4Fe-4S ferredoxin iron-sulfur binding domain protein - - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 ko:K03388 ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200 M00356,M00357,M00563,M00567 R04540,R11928,R11931,R11943,R11944 RC00011 ko00000,ko00001,ko00002,ko01000 - - - Fer4,Fer4_7,Pyr_redox_2 k59_801885_1 1415778.JQMM01000001_gene2172 1.02e-11 71.2 COG0729@1|root,COG0729@2|Bacteria,1MUKM@1224|Proteobacteria,1RNQ3@1236|Gammaproteobacteria,1J531@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M M COG4775 Outer membrane protein protective antigen OMA87 - - - ko:K07278 - - - - ko00000,ko02000 1.B.33.2.4 - - Bac_surface_Ag,POTRA,POTRA_TamA_1 k59_405981_2 1122137.AQXF01000001_gene2524 8.52e-126 371.0 COG5323@1|root,COG5323@2|Bacteria,1MW8S@1224|Proteobacteria,2TREI@28211|Alphaproteobacteria 28211|Alphaproteobacteria S ATP-binding protein' - - - - - - - - - - - - Terminase_3,Terminase_6,Terminase_6C k59_1536001_1 316407.85676625 8.82e-132 392.0 COG1640@1|root,COG1640@2|Bacteria,1QTVJ@1224|Proteobacteria,1RMJW@1236|Gammaproteobacteria,3XP9K@561|Escherichia 1236|Gammaproteobacteria G beta-maltose 4-alpha-glucanotransferase activity malQ GO:0000023,GO:0000025,GO:0003674,GO:0003824,GO:0004133,GO:0004134,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0005977,GO:0005984,GO:0006073,GO:0006091,GO:0006112,GO:0008150,GO:0008152,GO:0009056,GO:0009311,GO:0009313,GO:0009987,GO:0015980,GO:0016052,GO:0016740,GO:0016757,GO:0016758,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044262,GO:0044264,GO:0044275,GO:0044424,GO:0044444,GO:0044464,GO:0046352,GO:0055114,GO:0071704,GO:1901575 2.4.1.25 ko:K00705 ko00500,ko01100,map00500,map01100 - R05196 RC00049 ko00000,ko00001,ko01000 - GH77 iECIAI1_1343.ECIAI1_3560,iECO111_1330.ECO111_4225,iECO26_1355.ECO26_4504,iEcE24377_1341.EcE24377A_3892,iUMNK88_1353.UMNK88_4184,iYL1228.KPN_03786 Glyco_hydro_77 k59_123795_1 1123393.KB891331_gene2916 1.66e-32 118.0 COG1416@1|root,COG1416@2|Bacteria,1RE8C@1224|Proteobacteria,2VV8B@28216|Betaproteobacteria,1KT2D@119069|Hydrogenophilales 119069|Hydrogenophilales S DsrE/DsrF-like family - - - - - - - - - - - - DrsE k59_10866_1 556269.ACDQ01000011_gene226 6.51e-33 126.0 COG0133@1|root,COG0133@2|Bacteria,1MUS8@1224|Proteobacteria,2VHV3@28216|Betaproteobacteria,473H7@75682|Oxalobacteraceae 28216|Betaproteobacteria E The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine trpB GO:0000162,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0042802,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.2.1.20 ko:K01696 ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230 M00023 R00674,R02340,R02722 RC00209,RC00210,RC00700,RC00701,RC02868 ko00000,ko00001,ko00002,ko01000 - - - PALP k59_10866_2 883.DvMF_1740 1.13e-30 117.0 COG0159@1|root,COG0159@2|Bacteria,1MXJV@1224|Proteobacteria,42N5B@68525|delta/epsilon subdivisions,2WJX4@28221|Deltaproteobacteria,2M9V0@213115|Desulfovibrionales 28221|Deltaproteobacteria E The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate trpA - 4.2.1.20 ko:K01695 ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230 M00023 R00674,R02340,R02722 RC00209,RC00210,RC00700,RC00701,RC02868 ko00000,ko00001,ko00002,ko01000 - - - Trp_syntA k59_688477_1 181119.XP_005528546.1 6.03e-13 77.0 KOG2853@1|root,KOG2853@2759|Eukaryota,38ZPZ@33154|Opisthokonta,3B96U@33208|Metazoa,3CXNE@33213|Bilateria,488E7@7711|Chordata,493ZN@7742|Vertebrata,4GUBW@8782|Aves 33208|Metazoa S FAD-dependent oxidoreductase domain-containing protein 1 FOXRED1 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0005746,GO:0005747,GO:0006996,GO:0007005,GO:0008150,GO:0008152,GO:0009987,GO:0010257,GO:0016020,GO:0016043,GO:0016491,GO:0019866,GO:0022607,GO:0030964,GO:0031090,GO:0031966,GO:0031967,GO:0031975,GO:0032981,GO:0032991,GO:0033108,GO:0034622,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043933,GO:0044085,GO:0044422,GO:0044424,GO:0044425,GO:0044429,GO:0044444,GO:0044446,GO:0044455,GO:0044464,GO:0045271,GO:0055114,GO:0065003,GO:0070469,GO:0071840,GO:0098796,GO:0098798,GO:0098800,GO:0098803,GO:1902494,GO:1990204 - ko:K18166 - - - - ko00000,ko03029 - - - DAO k59_970481_1 1463861.JNXE01000039_gene4662 1.22e-53 174.0 COG1247@1|root,COG1247@2|Bacteria,2IHSY@201174|Actinobacteria 201174|Actinobacteria M acetyltransferase bar - 2.3.1.183 ko:K03823 ko00440,ko01130,map00440,map01130 - R08871,R08938 RC00004,RC00064 ko00000,ko00001,ko01000 - - - Acetyltransf_4 k59_1310238_1 999550.KI421507_gene3390 5.78e-09 58.5 COG0249@1|root,COG0249@2|Bacteria,1MUGX@1224|Proteobacteria,2TQRR@28211|Alphaproteobacteria 28211|Alphaproteobacteria L that it carries out the mismatch recognition step. This protein has a weak ATPase activity mutS GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - ko:K03555 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V k59_1310238_2 502025.Hoch_4694 2.48e-18 83.6 COG0084@1|root,COG0084@2|Bacteria,1MUC0@1224|Proteobacteria,42MMS@68525|delta/epsilon subdivisions,2WMUI@28221|Deltaproteobacteria,2YUWH@29|Myxococcales 28221|Deltaproteobacteria L TatD family tatD - - ko:K03424 - - - - ko00000,ko01000 - - - Fer4_14,Radical_SAM,TatD_DNase k59_1761936_2 697282.Mettu_1832 1.09e-43 145.0 COG0756@1|root,COG0756@2|Bacteria,1RA7P@1224|Proteobacteria,1S233@1236|Gammaproteobacteria,1XF3I@135618|Methylococcales 135618|Methylococcales F This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA dut GO:0003674,GO:0003824,GO:0004170,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009262,GO:0009394,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0019637,GO:0019692,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0047429,GO:0055086,GO:0071704,GO:1901135,GO:1901360 3.6.1.23 ko:K01520 ko00240,ko00983,ko01100,map00240,map00983,map01100 M00053 R02100,R11896 RC00002 ko00000,ko00001,ko00002,ko01000,ko03400 - - - dUTPase k59_406012_1 1254432.SCE1572_09685 5.67e-29 109.0 COG1193@1|root,COG1193@2|Bacteria,1NCS6@1224|Proteobacteria,42VGJ@68525|delta/epsilon subdivisions,2WRA6@28221|Deltaproteobacteria,2YVNG@29|Myxococcales 28221|Deltaproteobacteria L Smr domain - - - - - - - - - - - - Smr k59_406012_2 290398.Csal_0174 9.57e-35 125.0 COG3703@1|root,COG3703@2|Bacteria,1QA7D@1224|Proteobacteria,1S2MT@1236|Gammaproteobacteria,1XJWH@135619|Oceanospirillales 135619|Oceanospirillales P Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides - - - - - - - - - - - - ChaC k59_575338_1 717785.HYPMC_1567 2.61e-19 97.8 COG0500@1|root,COG0500@2|Bacteria,1R53Q@1224|Proteobacteria,2U4WJ@28211|Alphaproteobacteria 28211|Alphaproteobacteria Q Methyltransferase domain - - - ko:K19620 ko02020,map02020 - - - ko00000,ko00001 - - - Methyltransf_25 k59_1536036_1 330214.NIDE4018 1.79e-25 107.0 COG0488@1|root,COG0488@2|Bacteria 2|Bacteria L (ABC) transporter - - - ko:K15738 - - - - ko00000,ko02000 3.A.1.120.6 - - ABC_tran,ABC_tran_CTD,ABC_tran_Xtn k59_236275_1 338969.Rfer_0637 2.53e-43 146.0 COG2905@1|root,COG2905@2|Bacteria,1N7MU@1224|Proteobacteria,2VVGU@28216|Betaproteobacteria 28216|Betaproteobacteria T Domain in cystathionine beta-synthase and other proteins. - - - - - - - - - - - - CBS k59_1366667_1 1088721.NSU_0383 6.56e-96 283.0 COG0047@1|root,COG0047@2|Bacteria,1MU4Y@1224|Proteobacteria,2TS67@28211|Alphaproteobacteria,2K0NC@204457|Sphingomonadales 204457|Sphingomonadales F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL purQ - 6.3.5.3 ko:K01952 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04463 RC00010,RC01160 ko00000,ko00001,ko00002,ko01000 - - - GATase_5 k59_1366667_2 158500.BV97_01329 9.07e-44 142.0 COG1828@1|root,COG1828@2|Bacteria,1N83G@1224|Proteobacteria,2UF7S@28211|Alphaproteobacteria,2K5YV@204457|Sphingomonadales 204457|Sphingomonadales F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL purS - 6.3.5.3 ko:K01952 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04463 RC00010,RC01160 ko00000,ko00001,ko00002,ko01000 - - - PurS k59_10877_1 471854.Dfer_1046 2.78e-12 66.2 COG0057@1|root,COG0057@2|Bacteria,4NEMF@976|Bacteroidetes,47KPU@768503|Cytophagia 976|Bacteroidetes G Belongs to the glyceraldehyde-3-phosphate dehydrogenase family gap - 1.2.1.12 ko:K00134 ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01061 RC00149 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - Gp_dh_C,Gp_dh_N k59_10877_2 247634.GPB2148_1532 1.56e-73 229.0 COG0057@1|root,COG0057@2|Bacteria,1NT8P@1224|Proteobacteria,1SJQU@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain - - - - - - - - - - - - Gp_dh_C,Gp_dh_N k59_293513_1 1123059.KB823013_gene502 1.64e-33 134.0 COG1629@1|root,COG1629@2|Bacteria,1MVSG@1224|Proteobacteria 1224|Proteobacteria P Carboxypeptidase regulatory-like domain - - - - - - - - - - - - CarboxypepD_reg k59_1705248_1 436308.Nmar_0034 1.39e-111 333.0 COG2512@1|root,arCOG00374@2157|Archaea,41SUX@651137|Thaumarchaeota 651137|Thaumarchaeota K membrane-associated protein domain - - - - - - - - - - - - - k59_180055_1 158500.BV97_01712 8.63e-25 105.0 COG3391@1|root,COG3391@2|Bacteria,1R53R@1224|Proteobacteria,2U1FC@28211|Alphaproteobacteria,2K0VC@204457|Sphingomonadales 204457|Sphingomonadales S amine dehydrogenase activity - - - - - - - - - - - - - k59_10889_1 1122137.AQXF01000002_gene254 2.69e-109 327.0 COG0004@1|root,COG0004@2|Bacteria,1NR9F@1224|Proteobacteria,2TT2J@28211|Alphaproteobacteria 28211|Alphaproteobacteria P ammonium transporter' amt_1 - - ko:K03320 - - - - ko00000,ko02000 1.A.11 - - Ammonium_transp k59_858651_1 1229909.NSED_00805 3.26e-142 406.0 COG1032@1|root,arCOG01363@2157|Archaea,41S6P@651137|Thaumarchaeota 651137|Thaumarchaeota C Radical SAM - - - - - - - - - - - - Radical_SAM k59_350068_1 338969.Rfer_1891 1.49e-102 323.0 COG0446@1|root,COG1902@1|root,COG0446@2|Bacteria,COG1902@2|Bacteria,1MVE0@1224|Proteobacteria,2VIW3@28216|Betaproteobacteria,4ABSX@80864|Comamonadaceae 28216|Betaproteobacteria C NADH flavin oxidoreductase NADH oxidase fadH - 1.3.1.34 ko:K00219 - - - - ko00000,ko01000 - - - ECH_1,Oxidored_FMN,Pyr_redox_2 k59_1310268_2 391616.OA238_160p1320 1.66e-51 179.0 COG5476@1|root,COG5476@2|Bacteria,1MX4P@1224|Proteobacteria,2TS1C@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Involved in peptidolytic degradation of cyclic heptapeptide hepatotoxin microcystin (MC) - - - - - - - - - - - - DUF1485,MlrC_C k59_462619_1 520709.F985_03658 5.3e-102 304.0 COG2805@1|root,COG2805@2|Bacteria,1MU3J@1224|Proteobacteria,1RN8G@1236|Gammaproteobacteria,3NJ7T@468|Moraxellaceae 1236|Gammaproteobacteria NU twitching motility protein pilT GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - ko:K02669 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE k59_518787_1 1454004.AW11_02472 6.56e-84 264.0 COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,2VJ5E@28216|Betaproteobacteria,1KQBH@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria I AMP-binding enzyme bclA_2 - 6.2.1.1 ko:K01895 ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200 M00357 R00235,R00236,R00316,R00926,R01354 RC00004,RC00012,RC00043,RC00070,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000,ko01004 - - - AMP-binding,AMP-binding_C k59_123839_1 1123269.NX02_07390 1.94e-115 346.0 COG0146@1|root,COG0146@2|Bacteria,1QU46@1224|Proteobacteria,2TVYU@28211|Alphaproteobacteria,2K11U@204457|Sphingomonadales 204457|Sphingomonadales EQ PFAM Hydantoinase B oxoprolinase - - 3.5.2.14 ko:K01474 ko00330,ko01100,map00330,map01100 - R03187 RC00632 ko00000,ko00001,ko01000 - - - Hydantoinase_B k59_1366697_1 316407.85676746 1.71e-136 392.0 COG0202@1|root,COG0202@2|Bacteria,1MU75@1224|Proteobacteria,1RMU3@1236|Gammaproteobacteria,3XMRW@561|Escherichia 1236|Gammaproteobacteria K catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoA GO:0003674,GO:0003824,GO:0003899,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006354,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576 2.7.7.6 ko:K03040 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_A_CTD,RNA_pol_A_bac,RNA_pol_L k59_518799_1 945713.IALB_2247 2.89e-65 212.0 COG2208@1|root,COG2208@2|Bacteria 2|Bacteria T phosphoserine phosphatase activity - - 3.1.3.3 ko:K07315 - - - - ko00000,ko01000,ko03021 - - - SpoIIE k59_1761976_1 314285.KT71_02157 1.06e-11 62.8 COG0512@1|root,COG0512@2|Bacteria,1MV5Y@1224|Proteobacteria,1RMQW@1236|Gammaproteobacteria,1J858@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Peptidase C26 pabA GO:0000162,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005950,GO:0006082,GO:0006520,GO:0006568,GO:0006575,GO:0006576,GO:0006586,GO:0006725,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009108,GO:0009308,GO:0009309,GO:0009396,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0018130,GO:0019438,GO:0019752,GO:0032991,GO:0034641,GO:0042398,GO:0042401,GO:0042430,GO:0042435,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0046653,GO:0046654,GO:0046820,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494 2.6.1.85,4.1.3.27 ko:K01658,ko:K01664 ko00400,ko00405,ko00790,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map00790,map01100,map01110,map01130,map01230,map02024,map02025 M00023 R00985,R00986,R01716 RC00010,RC01418,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 - - iAPECO1_1312.APECO1_3095,iEC042_1314.EC042_3623,iECABU_c1320.ECABU_c37840,iECED1_1282.ECED1_4024,iECNA114_1301.ECNA114_3463,iECOK1_1307.ECOK1_3780,iECP_1309.ECP_3451,iECS88_1305.ECS88_3751,iECSF_1327.ECSF_3187,iLF82_1304.LF82_1586,iNRG857_1313.NRG857_16660,iUMN146_1321.UM146_16880,iUTI89_1310.UTI89_C3863,ic_1306.c4135 GATase k59_1761976_2 1397528.Q671_01365 1.16e-62 206.0 COG0147@1|root,COG0147@2|Bacteria,1MVBJ@1224|Proteobacteria,1RMSE@1236|Gammaproteobacteria,1XIBT@135619|Oceanospirillales 135619|Oceanospirillales E Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia trpE - 4.1.3.27 ko:K01657 ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025 M00023 R00985,R00986 RC00010,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 - - - Anth_synt_I_N,Chorismate_bind k59_131637_2 1229909.NSED_08220 3.01e-70 216.0 COG1986@1|root,arCOG01223@2157|Archaea,41SKV@651137|Thaumarchaeota 651137|Thaumarchaeota H Cytidylyltransferase-like - - 2.7.7.3 ko:K02201 ko00770,ko01100,map00770,map01100 M00120 R03035 RC00002 ko00000,ko00001,ko00002,ko01000 - - - CTP_transf_like k59_131637_3 1229909.NSED_05055 3.1e-57 180.0 arCOG08684@1|root,arCOG08684@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_470379_1 396588.Tgr7_3027 3.81e-36 129.0 COG3168@1|root,COG3168@2|Bacteria,1RI6V@1224|Proteobacteria,1S6VJ@1236|Gammaproteobacteria,1WYAC@135613|Chromatiales 135613|Chromatiales NU pilus assembly protein PilP - - - ko:K02665 - - - - ko00000,ko02035,ko02044 - - - PilP k59_1769816_1 436308.Nmar_1794 1.42e-228 662.0 COG1933@1|root,arCOG04447@2157|Archaea,41SYW@651137|Thaumarchaeota 651137|Thaumarchaeota L Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase polC - 2.7.7.7 ko:K02322 ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030 M00264 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032 - - - PolC_DP2 k59_1657568_1 436308.Nmar_0223 7.94e-136 390.0 COG0788@1|root,arCOG02826@2157|Archaea,41S78@651137|Thaumarchaeota 651137|Thaumarchaeota F Formyl transferase - - 3.5.1.10 ko:K01433 ko00630,ko00670,map00630,map00670 - R00944 RC00026,RC00111 ko00000,ko00001,ko01000 - - - ACT_6,Formyl_trans_N k59_1374940_1 1278309.KB907101_gene792 3e-29 108.0 COG2920@1|root,COG2920@2|Bacteria,1RGVG@1224|Proteobacteria,1S5ZA@1236|Gammaproteobacteria,1XKFS@135619|Oceanospirillales 135619|Oceanospirillales P part of a sulfur-relay system tusE - - ko:K11179 ko04122,map04122 - - - ko00000,ko00001,ko01000,ko03016 - - - DsrC k59_1374940_2 626887.J057_22315 1.06e-43 149.0 COG0670@1|root,COG0670@2|Bacteria,1MU69@1224|Proteobacteria,1RRVZ@1236|Gammaproteobacteria,4653K@72275|Alteromonadaceae 1236|Gammaproteobacteria S Belongs to the BI1 family yccA GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0016021,GO:0019222,GO:0030162,GO:0031224,GO:0044425,GO:0044464,GO:0050789,GO:0051171,GO:0051246,GO:0060255,GO:0065007,GO:0071944,GO:0080090 - ko:K19416 - M00742 - - ko00000,ko00002,ko02000 1.A.14.2.1 - - Bax1-I k59_1148177_1 1122137.AQXF01000003_gene2361 2.04e-67 219.0 COG1115@1|root,COG1115@2|Bacteria,1MUI3@1224|Proteobacteria,2TQVA@28211|Alphaproteobacteria 28211|Alphaproteobacteria E alanine symporter - - - ko:K03310 - - - - ko00000 2.A.25 - - Na_Ala_symp k59_1148177_2 1457393.AZ09_08375 4.32e-13 66.6 COG0521@1|root,COG0521@2|Bacteria,1R9W2@1224|Proteobacteria,2TTA8@28211|Alphaproteobacteria,2JRSX@204441|Rhodospirillales 204441|Rhodospirillales H May be involved in the biosynthesis of molybdopterin moaB - 2.7.7.75 ko:K03638 ko00790,ko01100,map00790,map01100 - R09726 RC00002 ko00000,ko00001,ko01000 - - - MoCF_biosynth k59_1374947_1 1380390.JIAT01000011_gene2600 5.05e-41 141.0 COG0094@1|root,COG0094@2|Bacteria,2GJW7@201174|Actinobacteria,4CQ45@84995|Rubrobacteria 84995|Rubrobacteria J This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits rplE - - ko:K02931 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L5,Ribosomal_L5_C k59_1374947_2 1121468.AUBR01000044_gene1850 2.95e-18 78.2 COG0198@1|root,COG0198@2|Bacteria,1V9ZQ@1239|Firmicutes,24MY0@186801|Clostridia,42GS5@68295|Thermoanaerobacterales 186801|Clostridia J One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit rplX - - ko:K02895 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - KOW,ribosomal_L24 k59_1430576_1 198214.SF1204 2.74e-128 382.0 COG3284@1|root,COG3284@2|Bacteria,1NRG5@1224|Proteobacteria,1RQQD@1236|Gammaproteobacteria 1236|Gammaproteobacteria KQ Positively regulates the dhaKLM operon from a sigma-70 promoter dhaR GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031326,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576,GO:1903506,GO:2000112,GO:2001141 - ko:K05880 - - - - ko00000,ko03000 - - - GAF,HTH_8,PAS,Sigma54_activat k59_358129_1 96561.Dole_0006 3.69e-64 214.0 COG0305@1|root,COG0305@2|Bacteria,1MUG9@1224|Proteobacteria,42M7X@68525|delta/epsilon subdivisions,2WJCA@28221|Deltaproteobacteria,2MHKJ@213118|Desulfobacterales 28221|Deltaproteobacteria L it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins dnaB - 3.6.4.12 ko:K02314 ko03030,ko04112,map03030,map04112 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB,DnaB_C k59_1204966_1 243233.MCA2131 1.26e-87 285.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1XDW6@135618|Methylococcales 135618|Methylococcales V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K18138 ko01501,ko01503,map01501,map01503 M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000 2.A.6.2 - - ACR_tran k59_18820_1 1144305.PMI02_05421 3.88e-124 379.0 COG2307@1|root,COG2308@1|root,COG2307@2|Bacteria,COG2308@2|Bacteria,1MX5P@1224|Proteobacteria,2TRJE@28211|Alphaproteobacteria,2JZVX@204457|Sphingomonadales 204457|Sphingomonadales S Circularly permuted ATP-grasp type 2 - - - - - - - - - - - - Alpha-E,CP_ATPgrasp_2 k59_1261180_1 272560.BPSS0205 8.48e-44 162.0 COG3829@1|root,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria,2VJT5@28216|Betaproteobacteria,1K2PB@119060|Burkholderiaceae 28216|Betaproteobacteria KT propionate catabolism operon regulatory protein prpR - - ko:K02688 - - - - ko00000,ko03000 - - - HTH_8,PAS,PAS_4,PAS_8,PrpR_N,Sigma54_activat k59_1769866_1 351348.Maqu_2770 1.6e-45 157.0 COG0324@1|root,COG0324@2|Bacteria,1MUB2@1224|Proteobacteria,1RMDU@1236|Gammaproteobacteria,465RN@72275|Alteromonadaceae 1236|Gammaproteobacteria J Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) miaA GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006417,GO:0006725,GO:0006807,GO:0006950,GO:0008033,GO:0008150,GO:0008152,GO:0009266,GO:0009408,GO:0009451,GO:0009628,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010608,GO:0016070,GO:0016740,GO:0016765,GO:0019222,GO:0031323,GO:0031326,GO:0032268,GO:0033554,GO:0034248,GO:0034470,GO:0034605,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043555,GO:0044237,GO:0044238,GO:0046483,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051246,GO:0051716,GO:0052381,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1990497,GO:2000112,GO:2000765 2.5.1.75 ko:K00791 ko00908,ko01100,ko01110,map00908,map01100,map01110 - R01122 RC02820 ko00000,ko00001,ko01000,ko01006,ko03016 - - - IPPT k59_1769866_2 472759.Nhal_3197 7.3e-19 83.6 COG0226@1|root,COG0226@2|Bacteria,1N19C@1224|Proteobacteria,1SEQX@1236|Gammaproteobacteria,1WZ27@135613|Chromatiales 135613|Chromatiales P COG0226 ABC-type phosphate transport system, periplasmic component - - - - - - - - - - - - PBP_like_2 k59_1091842_1 637389.Acaty_c0056 2.99e-14 78.6 COG1538@1|root,COG1538@2|Bacteria,1MWX5@1224|Proteobacteria,1S4SH@1236|Gammaproteobacteria,2NCF7@225057|Acidithiobacillales 225057|Acidithiobacillales MU CyaE is necessary for transport of calmodulin-sensitive adenylate cyclase-hemolysin (cyclolysin) - - - - - - - - - - - - OEP k59_1318408_1 436308.Nmar_0994 3.43e-105 311.0 COG0596@1|root,arCOG01648@2157|Archaea,41SFU@651137|Thaumarchaeota 651137|Thaumarchaeota S Alpha beta hydrolase - - - - - - - - - - - - Abhydrolase_1 k59_1713251_1 472759.Nhal_3420 1.92e-75 249.0 COG1674@1|root,COG3266@1|root,COG1674@2|Bacteria,COG3266@2|Bacteria,1MVPI@1224|Proteobacteria,1RM9A@1236|Gammaproteobacteria,1WWP6@135613|Chromatiales 135613|Chromatiales D DNA segregation ATPase FtsK SpoIIIE - - - ko:K03466 - - - - ko00000,ko03036 3.A.12 - - FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma k59_358160_1 768671.ThimaDRAFT_3921 3.76e-12 73.9 COG0642@1|root,COG2199@1|root,COG2205@2|Bacteria,COG3706@2|Bacteria,1NRP8@1224|Proteobacteria,1SKTW@1236|Gammaproteobacteria,1X2RR@135613|Chromatiales 135613|Chromatiales T response regulator receiver - - - - - - - - - - - - DUF2222,HATPase_c,HisKA,Hpt,PAS_9,Response_reg k59_1488130_1 1500259.JQLD01000010_gene4889 1.21e-13 73.2 COG2304@1|root,COG2304@2|Bacteria,1PH4N@1224|Proteobacteria,2TQTJ@28211|Alphaproteobacteria,4BB4P@82115|Rhizobiaceae 28211|Alphaproteobacteria S Protein of unknown function (DUF1194) - - - - - - - - - - - - DUF1194 k59_413925_1 246197.MXAN_6779 5.92e-58 191.0 COG2171@1|root,COG2171@2|Bacteria,1MU0Y@1224|Proteobacteria,42SPQ@68525|delta/epsilon subdivisions,2WPX1@28221|Deltaproteobacteria,2YWQX@29|Myxococcales 28221|Deltaproteobacteria E Belongs to the transferase hexapeptide repeat family dapD - 2.3.1.117 ko:K00674 ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230 M00016 R04365 RC00004,RC01136 ko00000,ko00001,ko00002,ko01000 - - - Hexapep,Hexapep_2,THDPS_N_2 k59_1769895_1 436308.Nmar_0957 6.09e-68 228.0 COG0308@1|root,arCOG02969@2157|Archaea,41SJH@651137|Thaumarchaeota 651137|Thaumarchaeota E Peptidase family M1 domain - - 3.4.11.2 ko:K01256,ko:K13722 ko00480,ko01100,map00480,map01100 - R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 - - - ERAP1_C,Peptidase_M1 k59_1713272_1 1121897.AUGO01000008_gene2606 2.32e-35 139.0 COG3291@1|root,COG3693@1|root,COG3291@2|Bacteria,COG3693@2|Bacteria,4NNHP@976|Bacteroidetes,1ICU8@117743|Flavobacteriia,2NUVV@237|Flavobacterium 976|Bacteroidetes N Fibronectin type 3 domain - - - - - - - - - - - - CHU_C,VCBS,fn3 k59_810009_1 2340.JV46_13300 2.48e-54 190.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1J582@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K18989 - M00720 - - ko00000,ko00002,ko02000 2.A.6.2.30 - - ACR_tran k59_358182_1 395961.Cyan7425_0791 3.48e-30 123.0 COG0515@1|root,COG0642@1|root,COG3899@1|root,COG0515@2|Bacteria,COG2205@2|Bacteria,COG3899@2|Bacteria,1GD97@1117|Cyanobacteria,3KHHW@43988|Cyanothece 1117|Cyanobacteria T Serine Threonine protein kinase - - - - - - - - - - - - AAA_16,GAF,HATPase_c,HisKA,Pkinase,Response_reg k59_131702_2 1347342.BN863_23400 1.36e-57 194.0 COG2885@1|root,COG2885@2|Bacteria,4NE6G@976|Bacteroidetes,1HXNY@117743|Flavobacteriia 976|Bacteroidetes M Belongs to the ompA family - - - - - - - - - - - - CarboxypepD_reg,OmpA,PD40 k59_1261214_1 1140003.I573_00674 5.24e-23 100.0 COG2071@1|root,COG2071@2|Bacteria,1V1KC@1239|Firmicutes,4HI59@91061|Bacilli,4AZ7W@81852|Enterococcaceae 91061|Bacilli S Peptidase C26 puuD - - ko:K07010 - - - - ko00000,ko01002 - - - Peptidase_C26 k59_1430619_1 717773.Thicy_1187 4.75e-13 68.2 COG0752@1|root,COG0752@2|Bacteria,1MVCJ@1224|Proteobacteria,1RMYI@1236|Gammaproteobacteria,4604S@72273|Thiotrichales 72273|Thiotrichales J glycyl-tRNA synthetase, alpha subunit glyQ - 6.1.1.14 ko:K01878 ko00970,map00970 M00360 R03654 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_2e k59_1430619_2 754476.Q7A_608 1.27e-37 142.0 COG0751@1|root,COG0751@2|Bacteria,1MV2F@1224|Proteobacteria,1RNR3@1236|Gammaproteobacteria,45ZWF@72273|Thiotrichales 72273|Thiotrichales J Glycyl-tRNA synthetase beta subunit glyS - 6.1.1.14 ko:K01879 ko00970,map00970 M00360 R03654 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DALR_1,tRNA_synt_2f k59_358191_1 572477.Alvin_0197 2.68e-17 80.1 COG0189@1|root,COG0189@2|Bacteria,1MVUA@1224|Proteobacteria,1RMU0@1236|Gammaproteobacteria,1WVY1@135613|Chromatiales 135613|Chromatiales HJ Belongs to the prokaryotic GSH synthase family gshB - 6.3.2.3 ko:K01920 ko00270,ko00480,ko01100,map00270,map00480,map01100 M00118 R00497,R10994 RC00096,RC00141 ko00000,ko00001,ko00002,ko01000 - - - GSH-S_ATP,GSH-S_N k59_358191_2 626887.J057_08821 6.22e-11 64.3 COG0810@1|root,COG0810@2|Bacteria,1MUMT@1224|Proteobacteria,1S3A6@1236|Gammaproteobacteria,465SW@72275|Alteromonadaceae 1236|Gammaproteobacteria M COG0810 Periplasmic protein TonB, links inner and outer membranes tonB3 - - ko:K03832 - - - - ko00000,ko02000 2.C.1.1 - - TonB_C k59_188456_1 1121933.AUHH01000010_gene2612 8.67e-40 151.0 COG0443@1|root,COG0443@2|Bacteria,2I90R@201174|Actinobacteria 201174|Actinobacteria O Belongs to the heat shock protein 70 family hscA - - - - - - - - - - - HSP70 k59_1148232_1 76114.ebA3828 1.33e-84 254.0 COG0087@1|root,COG0087@2|Bacteria,1MUST@1224|Proteobacteria,2VJ3V@28216|Betaproteobacteria,2KV3R@206389|Rhodocyclales 206389|Rhodocyclales J One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit rplC - - ko:K02906 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L3 k59_358194_1 234267.Acid_1734 4.22e-45 166.0 COG0612@1|root,COG0612@2|Bacteria,3Y2UB@57723|Acidobacteria 57723|Acidobacteria S PFAM Peptidase M16 - - - ko:K07263 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M16,Peptidase_M16_C k59_1769905_1 314275.MADE_1000315 3.67e-95 290.0 COG0156@1|root,COG0156@2|Bacteria,1MVVH@1224|Proteobacteria,1RNS6@1236|Gammaproteobacteria,465DM@72275|Alteromonadaceae 1236|Gammaproteobacteria H Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA kbl - 2.3.1.29 ko:K00639 ko00260,map00260 - R00371 RC00004,RC00394 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_1_2 k59_1318454_1 1217705.F900_02401 5.44e-66 211.0 COG2805@1|root,COG2805@2|Bacteria,1MU3J@1224|Proteobacteria,1RN8G@1236|Gammaproteobacteria,3NJ7T@468|Moraxellaceae 1236|Gammaproteobacteria NU twitching motility protein pilT GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - ko:K02669 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE k59_526382_1 863365.XHC_0876 2.64e-88 272.0 COG0313@1|root,COG0313@2|Bacteria,1MU0E@1224|Proteobacteria,1RM7U@1236|Gammaproteobacteria,1X4QV@135614|Xanthomonadales 135614|Xanthomonadales H Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA rsmI - 2.1.1.198 ko:K07056 - - - - ko00000,ko01000,ko03009 - - - TP_methylase k59_1713320_1 1459636.NTE_02474 3.54e-83 264.0 COG0644@1|root,COG2440@1|root,arCOG00570@2157|Archaea,arCOG01984@2157|Archaea,41SXJ@651137|Thaumarchaeota 651137|Thaumarchaeota C Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains - - - ko:K00313 - - - - ko00000,ko01000 - - - - k59_470472_2 211165.AJLN01000120_gene770 9.16e-48 162.0 COG5486@1|root,COG5486@2|Bacteria,1GF5E@1117|Cyanobacteria 1117|Cyanobacteria S Predicted metal-binding integral membrane protein (DUF2182) - - - - - - - - - - - - DUF2182 k59_866922_2 797114.C475_03049 0.000766 44.3 COG0500@1|root,arCOG04989@2157|Archaea,2XWEU@28890|Euryarchaeota,23V0C@183963|Halobacteria 183963|Halobacteria Q COG0500 SAM-dependent methyltransferases - - - - - - - - - - - - Methyltransf_25 k59_696454_1 287.DR97_3816 8.79e-17 84.0 COG0611@1|root,COG0611@2|Bacteria,1MU9X@1224|Proteobacteria,1RNHU@1236|Gammaproteobacteria,1YE8Y@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria H Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 thiL GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009030,GO:0009058,GO:0009108,GO:0009110,GO:0009228,GO:0009229,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0017076,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0035639,GO:0036094,GO:0042357,GO:0042364,GO:0042723,GO:0042724,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046483,GO:0046872,GO:0051186,GO:0051188,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.7.4.16 ko:K00946 ko00730,ko01100,map00730,map01100 M00127 R00617 RC00002 ko00000,ko00001,ko00002,ko01000 - - iSFV_1184.SFV_0382 AIRS,AIRS_C k59_18887_1 765912.Thimo_3336 1.7e-52 181.0 COG0146@1|root,COG0146@2|Bacteria,1QU46@1224|Proteobacteria,1T2DW@1236|Gammaproteobacteria,1X2PB@135613|Chromatiales 135613|Chromatiales EQ PFAM Hydantoinase B oxoprolinase - - 3.5.2.14 ko:K01474 ko00330,ko01100,map00330,map01100 - R03187 RC00632 ko00000,ko00001,ko01000 - - - Hydantoinase_B k59_640186_1 436308.Nmar_0422 1.03e-152 441.0 COG0065@1|root,arCOG01698@2157|Archaea,41SYT@651137|Thaumarchaeota 651137|Thaumarchaeota E 3-isopropylmalate dehydratase, large subunit - - 4.2.1.33,4.2.1.35 ko:K01703 ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230 M00432,M00535 R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170 RC00497,RC00976,RC00977,RC01041,RC01046,RC03072 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase k59_76127_1 1122137.AQXF01000004_gene1784 3.04e-110 333.0 COG1574@1|root,COG1574@2|Bacteria,1MWP2@1224|Proteobacteria,2TTRU@28211|Alphaproteobacteria 28211|Alphaproteobacteria K metal-dependent hydrolase with the TIM-barrel fold - - - - - - - - - - - - Amidohydro_3 k59_1375046_1 391037.Sare_2491 1.79e-19 91.3 COG2141@1|root,COG2141@2|Bacteria,2GJ6T@201174|Actinobacteria,4DF11@85008|Micromonosporales 201174|Actinobacteria C Luciferase-like monooxygenase - - - - - - - - - - - - Bac_luciferase k59_866933_1 1000565.METUNv1_01859 5e-65 220.0 COG2307@1|root,COG2308@1|root,COG2307@2|Bacteria,COG2308@2|Bacteria,1MX5P@1224|Proteobacteria,2VJEU@28216|Betaproteobacteria,2KUBA@206389|Rhodocyclales 206389|Rhodocyclales S Circularly permuted ATP-grasp type 2 - - - - - - - - - - - - Alpha-E,CP_ATPgrasp_2 k59_188484_1 436308.Nmar_1245 1.37e-67 223.0 COG0419@1|root,COG1122@1|root,arCOG00202@2157|Archaea,arCOG00368@2157|Archaea,41S9P@651137|Thaumarchaeota 651137|Thaumarchaeota LP AAA domain - - - ko:K03546 - - - - ko00000,ko03400 - - - AAA_15 k59_188484_2 1229909.NSED_07010 1.13e-34 132.0 COG3794@1|root,arCOG10350@1|root,arCOG02926@2157|Archaea,arCOG10350@2157|Archaea 2157|Archaea C sister chromatid segregation - - - - - - - - - - - - Copper-bind,Kazal_1 k59_696479_1 383372.Rcas_2878 4.06e-52 181.0 COG1960@1|root,COG1960@2|Bacteria,2G7Q9@200795|Chloroflexi,37704@32061|Chloroflexia 32061|Chloroflexia C Acyl-CoA dehydrogenase, N-terminal domain - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_696481_1 1538295.JY96_19410 1.19e-34 129.0 COG0543@1|root,COG1018@1|root,COG0543@2|Bacteria,COG1018@2|Bacteria,1MV72@1224|Proteobacteria,2VKGZ@28216|Betaproteobacteria,1KJ5Q@119065|unclassified Burkholderiales 28216|Betaproteobacteria C Oxidoreductase FAD-binding domain - - 1.18.1.3 ko:K16246,ko:K18225,ko:K18293 ko00361,ko00362,ko00622,ko00623,ko00640,ko01100,ko01120,ko01220,map00361,map00362,map00622,map00623,map00640,map01100,map01120,map01220 M00419,M00548 R03560,R03608,R05266,R10042,R10043,R10702 RC00046,RC00269,RC00490,RC03249 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_6,Fer2,NAD_binding_1 k59_696481_2 1538295.JY96_19415 3.09e-51 173.0 COG3239@1|root,COG3239@2|Bacteria,1MW29@1224|Proteobacteria 1224|Proteobacteria I Alkane 1-monooxygenase alkB - 1.14.15.3 ko:K00496,ko:K10616,ko:K15757 ko00071,ko00622,ko00623,ko00930,ko01100,ko01120,ko01220,map00071,map00622,map00623,map00930,map01100,map01120,map01220 M00419,M00537 R01347,R02281,R02550,R05266,R05288,R05442,R05443,R06945 RC00269,RC00478 ko00000,ko00001,ko00002,ko01000 - - - FA_desaturase k59_1713342_1 1122137.AQXF01000001_gene3100 9.23e-66 223.0 COG1629@1|root,COG4771@2|Bacteria,1MU9K@1224|Proteobacteria,2TS65@28211|Alphaproteobacteria 28211|Alphaproteobacteria P COG1629 Outer membrane receptor proteins, mostly Fe transport - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_866953_1 641526.ADIWIN_1796 4.67e-93 279.0 COG1834@1|root,COG1834@2|Bacteria,4NEUJ@976|Bacteroidetes,1HWNG@117743|Flavobacteriia 976|Bacteroidetes E Cytochrome C biogenesis protein CcmF - - - - - - - - - - - - Amidinotransf k59_359452_1 314287.GB2207_08216 1.76e-51 187.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1J4MB@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_245497_1 314287.GB2207_00765 3.68e-64 206.0 COG1721@1|root,COG1721@2|Bacteria,1Q7RR@1224|Proteobacteria,1RNNP@1236|Gammaproteobacteria,1J5XC@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S conserved protein (some members contain a von Willebrand factor type A (vWA) domain) - - - - - - - - - - - - DUF58 k59_245511_1 1122137.AQXF01000006_gene704 1.57e-80 248.0 COG3958@1|root,COG3958@2|Bacteria,1N6QF@1224|Proteobacteria,2TTU8@28211|Alphaproteobacteria 28211|Alphaproteobacteria G Transketolase dxs_2 - 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 - - - Transket_pyr,Transketolase_C k59_1376252_1 1122137.AQXF01000005_gene1092 1.57e-30 127.0 COG1196@1|root,COG1196@2|Bacteria,1MUAQ@1224|Proteobacteria,2TRQG@28211|Alphaproteobacteria 28211|Alphaproteobacteria D Required for chromosome condensation and partitioning smc - - ko:K03529 - - - - ko00000,ko03036 - - - SMC_N k59_1601697_1 1229909.NSED_00645 4.04e-40 139.0 arCOG05463@1|root,arCOG05463@2157|Archaea,41SR3@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1601697_2 436308.Nmar_1571 3.43e-79 242.0 COG1634@1|root,arCOG04303@2157|Archaea,41SKX@651137|Thaumarchaeota 651137|Thaumarchaeota H Catalyzes the transfer of diphosphate from ATP to 6- hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6- hydroxymethyl-7,8-dihydropterin diphosphate (6-HMDP) mptE - 2.7.6.3 ko:K07142 ko00790,map00790 - R03503 RC00002,RC00017 ko00000,ko00001,ko01000 - - - MAF_flag10 k59_584570_1 266834.SMc02390 2.18e-08 55.5 COG0625@1|root,COG0625@2|Bacteria,1MUN3@1224|Proteobacteria,2TTVR@28211|Alphaproteobacteria,4B89I@82115|Rhizobiaceae 28211|Alphaproteobacteria O Belongs to the GST superfamily gst7 - - ko:K11209 - - - - ko00000,ko01000 - - - GST_C,GST_N,GST_N_3 k59_753968_1 1415778.JQMM01000001_gene488 1.02e-121 354.0 COG0568@1|root,COG0568@2|Bacteria,1MVWR@1224|Proteobacteria,1RMFR@1236|Gammaproteobacteria,1J4RB@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is involved in regulation of expression of heat shock genes rpoH GO:0000150,GO:0000976,GO:0000984,GO:0000985,GO:0000988,GO:0000990,GO:0001017,GO:0001046,GO:0001047,GO:0001067,GO:0001121,GO:0001130,GO:0001131,GO:0001140,GO:0001216,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006310,GO:0006351,GO:0006352,GO:0006355,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009009,GO:0009058,GO:0009059,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016020,GO:0016070,GO:0016987,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031421,GO:0032774,GO:0032991,GO:0032993,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043254,GO:0043565,GO:0044087,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0045893,GO:0045935,GO:0046483,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0140097,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2000142,GO:2001141 - ko:K03089 - - - - ko00000,ko03021 - - - Sigma70_r1_2,Sigma70_r2,Sigma70_r4 k59_1714490_1 234267.Acid_0024 5.11e-06 47.4 COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,3Y3FE@57723|Acidobacteria 2|Bacteria KU WD40 domain protein beta Propeller - - 2.7.11.1 ko:K08884,ko:K12132 - - - - ko00000,ko01000,ko01001 - - - PD40,Pkinase,WD40 k59_1714490_2 1234364.AMSF01000068_gene2154 3.77e-21 89.0 COG0229@1|root,COG0229@2|Bacteria,1RGWC@1224|Proteobacteria,1S5WI@1236|Gammaproteobacteria,1X6XB@135614|Xanthomonadales 135614|Xanthomonadales O COG0229 Conserved domain frequently associated with peptide methionine sulfoxide reductase - - 1.8.4.12 ko:K07305 - - - - ko00000,ko01000 - - - SelR k59_979192_1 1121087.AUCK01000005_gene794 1.48e-21 98.6 COG0514@1|root,COG0514@2|Bacteria,1TPN5@1239|Firmicutes,4H9QP@91061|Bacilli,1ZC4U@1386|Bacillus 91061|Bacilli L DNA helicase recQ GO:0003674,GO:0003676,GO:0003677,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005694,GO:0005737,GO:0006139,GO:0006259,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009295,GO:0009378,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0033554,GO:0034641,GO:0042623,GO:0043138,GO:0043140,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043590,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051276,GO:0051716,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363 3.6.4.12 ko:K03654 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,HRDC,HTH_40,Helicase_C,RQC,RecQ_Zn_bind k59_641154_1 795666.MW7_1271 4.5e-116 343.0 COG0649@1|root,COG0649@2|Bacteria,1MVIN@1224|Proteobacteria,2VHEC@28216|Betaproteobacteria,1K3FX@119060|Burkholderiaceae 28216|Betaproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoD - 1.6.5.3 ko:K00333 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_49kDa k59_1714495_1 1260251.SPISAL_05935 5.95e-144 438.0 COG0587@1|root,COG0587@2|Bacteria,1MUE4@1224|Proteobacteria,1RQA8@1236|Gammaproteobacteria,1WW62@135613|Chromatiales 135613|Chromatiales L DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase dnaE2 - 2.7.7.7 ko:K14162 - - - - ko00000,ko01000,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon k59_1551210_1 1123360.thalar_02390 1.38e-61 198.0 COG2801@1|root,COG2801@2|Bacteria,1MVXQ@1224|Proteobacteria,2TU72@28211|Alphaproteobacteria 28211|Alphaproteobacteria L COG2801 Transposase and inactivated derivatives - - - - - - - - - - - - HTH_21,rve k59_1551210_2 266264.Rmet_5542 8.56e-18 77.4 COG2963@1|root,COG2963@2|Bacteria,1N1AA@1224|Proteobacteria,2VSJA@28216|Betaproteobacteria,1K8EV@119060|Burkholderiaceae 28216|Betaproteobacteria L transposase IS3 IS911 family protein - - - - - - - - - - - - HTH_Tnp_1 k59_250559_1 391625.PPSIR1_18172 3.49e-99 300.0 COG1690@1|root,COG1690@2|Bacteria,1MUHA@1224|Proteobacteria,42PKM@68525|delta/epsilon subdivisions,2WJCP@28221|Deltaproteobacteria,2YUCG@29|Myxococcales 28221|Deltaproteobacteria S tRNA-splicing ligase RtcB rtcB - 6.5.1.3 ko:K14415 - - - - ko00000,ko01000,ko03016 - - - RtcB k59_1381545_1 1207055.C100_01630 4.93e-60 194.0 COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,2TQTP@28211|Alphaproteobacteria,2K2SD@204457|Sphingomonadales 204457|Sphingomonadales L Transposase - - - ko:K07486 - - - - ko00000 - - - DEDD_Tnp_IS110,Transposase_20 k59_873465_1 316407.4062225 1.17e-111 333.0 COG0471@1|root,COG0471@2|Bacteria,1MUSA@1224|Proteobacteria,1RMF3@1236|Gammaproteobacteria,3XM3A@561|Escherichia 1236|Gammaproteobacteria P Responsible for the uptake of citrate in exchange with the efflux of succinate, fumarate or tartrate. Has a relatively broad specificity for C(4)-dicarboxylates and tricarboxylates citT GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K09477 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.47.3.2 - iSSON_1240.SSON_0564 Na_sulph_symp k59_250564_2 977880.RALTA_A2957 3.38e-105 336.0 COG0086@1|root,COG0086@2|Bacteria,1MU3M@1224|Proteobacteria,2VIF3@28216|Betaproteobacteria,1K0RX@119060|Burkholderiaceae 28216|Betaproteobacteria K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoC - 2.7.7.6 ko:K03046 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5 k59_25468_1 880073.Calab_1195 4.68e-36 140.0 COG0841@1|root,COG0841@2|Bacteria,2NQI6@2323|unclassified Bacteria 2|Bacteria V AcrB/AcrD/AcrF family mdtB - - ko:K03296 - - - - ko00000 2.A.6.2 - - ACR_tran k59_1774192_1 1177154.Y5S_03739 2.11e-16 84.3 COG3209@1|root,COG3209@2|Bacteria,1MVV1@1224|Proteobacteria,1RP75@1236|Gammaproteobacteria,1XNUT@135619|Oceanospirillales 135619|Oceanospirillales M RHS Repeat - - - - - - - - - - - - RHS,RHS_repeat k59_250569_1 1283300.ATXB01000001_gene2476 1.16e-106 310.0 COG3335@1|root,COG3335@2|Bacteria,1N5WI@1224|Proteobacteria,1S5TZ@1236|Gammaproteobacteria,1XF5S@135618|Methylococcales 135618|Methylococcales L DDE superfamily endonuclease - - - - - - - - - - - - DDE_3 k59_927487_1 1280953.HOC_14982 1.94e-05 51.6 COG2825@1|root,COG2825@2|Bacteria,1NNT2@1224|Proteobacteria,2UN7C@28211|Alphaproteobacteria,43YQ4@69657|Hyphomonadaceae 28211|Alphaproteobacteria M Outer membrane protein (OmpH-like) - - - ko:K06142 - - - - ko00000 - - - OmpH k59_1211530_1 1205910.B005_3860 4.08e-98 318.0 COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,2GN09@201174|Actinobacteria,4EGYC@85012|Streptosporangiales 201174|Actinobacteria E GXGXG motif gltB - 1.4.1.13,1.4.1.14 ko:K00265 ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 - R00093,R00114,R00248 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - GATase_2,GXGXG,Glu_syn_central,Glu_synthase k59_1551243_1 316407.85676987 6.84e-147 432.0 COG1328@1|root,COG1328@2|Bacteria,1MWMS@1224|Proteobacteria,1RNHS@1236|Gammaproteobacteria,3XP9C@561|Escherichia 1236|Gammaproteobacteria F anaerobic ribonucleoside-triphosphate reductase nrdD GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008270,GO:0008998,GO:0009058,GO:0009117,GO:0009165,GO:0009262,GO:0009263,GO:0009265,GO:0009394,GO:0009987,GO:0015949,GO:0016491,GO:0016725,GO:0016728,GO:0017076,GO:0018130,GO:0019001,GO:0019103,GO:0019438,GO:0019637,GO:0019692,GO:0030554,GO:0031250,GO:0032552,GO:0032553,GO:0032554,GO:0032555,GO:0032556,GO:0032558,GO:0032559,GO:0032560,GO:0032564,GO:0032567,GO:0032991,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046385,GO:0046483,GO:0046872,GO:0046914,GO:0051065,GO:0055086,GO:0055114,GO:0071704,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901576 1.1.98.6 ko:K21636 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R11633,R11634,R11635,R11636 RC00613 ko00000,ko00001,ko00002,ko01000 - - iECIAI39_1322.ECIAI39_4713,iPC815.YPO3454 ATP-cone,NRDD k59_1607325_1 1265502.KB905946_gene1123 1.46e-86 283.0 COG5013@1|root,COG5013@2|Bacteria,1MW9S@1224|Proteobacteria,2VJ2F@28216|Betaproteobacteria,4A9MX@80864|Comamonadaceae 28216|Betaproteobacteria C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family narG - 1.7.5.1 ko:K00370,ko:K17050 ko00910,ko01120,ko02020,map00910,map01120,map02020 M00529,M00530,M00804 R00798,R01106,R09497 RC02812 ko00000,ko00001,ko00002,ko01000,ko02000 5.A.3.1,5.A.3.8 - - Molybdopterin,Molydop_binding,Nitr_red_alph_N k59_644941_1 1144305.PMI02_03530 5.78e-71 235.0 COG4232@1|root,COG4233@1|root,COG4232@2|Bacteria,COG4233@2|Bacteria,1MU8W@1224|Proteobacteria,2TTUM@28211|Alphaproteobacteria,2K11D@204457|Sphingomonadales 204457|Sphingomonadales CO Thiol disulfide interchange protein - - - - - - - - - - - - DsbC,DsbD,Thioredoxin_7 k59_873485_1 316407.85674308 1.24e-163 468.0 COG2160@1|root,COG2160@2|Bacteria,1MW0J@1224|Proteobacteria,1RQEF@1236|Gammaproteobacteria,3XN18@561|Escherichia 1236|Gammaproteobacteria G Catalyzes the conversion of L-arabinose to L-ribulose araA GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008733,GO:0009056,GO:0009058,GO:0009987,GO:0016052,GO:0016853,GO:0016860,GO:0016861,GO:0019321,GO:0019323,GO:0019566,GO:0019568,GO:0019569,GO:0019572,GO:0019637,GO:0044237,GO:0044238,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046373,GO:0051167,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901159,GO:1901575,GO:1901576 5.3.1.4 ko:K01804 ko00040,ko01100,map00040,map01100 - R01761 RC00516 ko00000,ko00001,ko01000 - - iAPECO1_1312.APECO1_1922,iB21_1397.B21_00063,iBWG_1329.BWG_0058,iE2348C_1286.E2348C_0063,iECBD_1354.ECBD_3555,iECD_1391.ECD_00064,iECED1_1282.ECED1_0061,iECIAI1_1343.ECIAI1_0062,iECNA114_1301.ECNA114_0050,iECO103_1326.ECO103_0063,iECO26_1355.ECO26_0064,iECOK1_1307.ECOK1_0061,iECP_1309.ECP_0063,iECS88_1305.ECS88_0065,iECSE_1348.ECSE_0062,iECW_1372.ECW_m0060,iEKO11_1354.EKO11_3852,iEcE24377_1341.EcE24377A_0064,iEcHS_1320.EcHS_A0066,iEcSMS35_1347.EcSMS35_0064,iEcolC_1368.EcolC_3595,iLF82_1304.LF82_0105,iNRG857_1313.NRG857_00320,iSBO_1134.SBO_0049,iSSON_1240.SSON_0068,iUMN146_1321.UM146_23095,iUTI89_1310.UTI89_C0067,iWFL_1372.ECW_m0060 Arabinose_Iso_C,Arabinose_Isome k59_308298_1 1096930.L284_03160 3.45e-38 137.0 COG3876@1|root,COG3876@2|Bacteria,1MX3S@1224|Proteobacteria,2U1KM@28211|Alphaproteobacteria,2K0PB@204457|Sphingomonadales 204457|Sphingomonadales S Protein of unknown function (DUF1343) - - - - - - - - - - - - DUF1343 k59_308298_2 1144305.PMI02_02989 8.78e-44 147.0 2C0PI@1|root,32VVI@2|Bacteria,1N1H7@1224|Proteobacteria,2UE1P@28211|Alphaproteobacteria,2K60G@204457|Sphingomonadales 204457|Sphingomonadales - - - - - - - - - - - - - - - k59_1043256_1 1279017.AQYJ01000027_gene1674 2.94e-48 164.0 COG0500@1|root,COG2226@2|Bacteria,1PN45@1224|Proteobacteria,1RP4K@1236|Gammaproteobacteria,466BJ@72275|Alteromonadaceae 1236|Gammaproteobacteria Q Mycolic acid cyclopropane synthetase yafE GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0008168,GO:0008757,GO:0016740,GO:0016741,GO:0032259,GO:0044424,GO:0044464 - - - - - - - - - - Methyltransf_11,Methyltransf_25 k59_1043256_2 517417.Cpar_0605 1.56e-68 210.0 COG0590@1|root,COG0590@2|Bacteria 2|Bacteria FJ tRNA wobble adenosine to inosine editing tadA - 3.5.4.1,3.5.4.33 ko:K01485,ko:K11991 ko00240,ko00330,ko01100,map00240,map00330,map01100 - R00974,R01411,R02922,R10223 RC00074,RC00477,RC00514,RC00809 ko00000,ko00001,ko01000,ko03016 - - - MafB19-deam,dCMP_cyt_deam_1 k59_1774201_1 269796.Rru_A1888 1.51e-17 79.0 COG1314@1|root,COG1314@2|Bacteria,1N8MF@1224|Proteobacteria,2UCIP@28211|Alphaproteobacteria,2JU8U@204441|Rhodospirillales 204441|Rhodospirillales U Preprotein translocase subunit SecG secG - - ko:K03075 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2 - - SecG k59_1774201_2 1156935.QWE_22186 6.56e-48 161.0 COG0149@1|root,COG0149@2|Bacteria,1MWK5@1224|Proteobacteria,2TS6I@28211|Alphaproteobacteria,4B7G1@82115|Rhizobiaceae 28211|Alphaproteobacteria G Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) tpiA GO:0003674,GO:0003824,GO:0004807,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006066,GO:0006071,GO:0006081,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0018130,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019400,GO:0019405,GO:0019438,GO:0019439,GO:0019563,GO:0019637,GO:0019682,GO:0019693,GO:0019751,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044262,GO:0044270,GO:0044271,GO:0044275,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046164,GO:0046166,GO:0046174,GO:0046184,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1901615,GO:1901616 5.3.1.1 ko:K01803 ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003 R01015 RC00423 ko00000,ko00001,ko00002,ko01000,ko04147 - - - TIM k59_1720053_1 1122603.ATVI01000005_gene3496 2.36e-43 159.0 COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,1S1MS@1236|Gammaproteobacteria,1X9IC@135614|Xanthomonadales 135614|Xanthomonadales S Adenylate cyclase - - - - - - - - - - - - - k59_644951_1 991905.SL003B_4136 9.91e-87 263.0 COG2801@1|root,COG2801@2|Bacteria,1MZ45@1224|Proteobacteria,2TTG7@28211|Alphaproteobacteria,4BT5R@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria L Integrase core domain - - - - - - - - - - - - HTH_29,rve,rve_3 k59_1265930_1 1112204.GPOL_c00690 1.63e-11 69.3 COG3173@1|root,COG3173@2|Bacteria,2GMZQ@201174|Actinobacteria,4GDHU@85026|Gordoniaceae 201174|Actinobacteria S Protein of unknown function (DUF1679) - - - - - - - - - - - - APH,EcKinase k59_1774204_1 1131266.ARWQ01000001_gene1176 5.74e-10 59.7 arCOG08038@1|root,arCOG08038@2157|Archaea,41SZN@651137|Thaumarchaeota 651137|Thaumarchaeota S protein secretion by the type IV secretion system - - - - - - - - - - - - - k59_1774204_3 436308.Nmar_0230 1.42e-14 68.9 COG0526@1|root,arCOG01972@2157|Archaea,41T6S@651137|Thaumarchaeota 651137|Thaumarchaeota O Thioredoxin - - - ko:K03671 ko04621,ko05418,map04621,map05418 - - - ko00000,ko00001,ko03110 - - - Thioredoxin k59_530926_1 1122604.JONR01000043_gene3178 1.87e-85 266.0 COG1622@1|root,COG1622@2|Bacteria,1MWHZ@1224|Proteobacteria,1RP4H@1236|Gammaproteobacteria,1X3IF@135614|Xanthomonadales 135614|Xanthomonadales C Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) ctaC - 1.9.3.1 ko:K02275 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.4,3.D.4.6 - - COX2,COX2_TM,Cytochrome_CBB3 k59_530926_2 1415779.JOMH01000001_gene3284 1.59e-153 446.0 COG0843@1|root,COG0843@2|Bacteria,1MU7S@1224|Proteobacteria,1RPC3@1236|Gammaproteobacteria,1X34C@135614|Xanthomonadales 135614|Xanthomonadales C Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B ctaD - 1.9.3.1 ko:K02274 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6 - - COX1 k59_983078_1 1485544.JQKP01000002_gene1376 5.28e-76 257.0 COG3419@1|root,COG3419@2|Bacteria,1NUAV@1224|Proteobacteria,2VHY8@28216|Betaproteobacteria,44V4V@713636|Nitrosomonadales 28216|Betaproteobacteria NU Neisseria PilC beta-propeller domain pilY1 - - ko:K02674 - - - - ko00000,ko02035,ko02044 - - - Neisseria_PilC k59_1043270_1 1280946.HY29_01130 5.87e-08 57.4 COG0436@1|root,COG0436@2|Bacteria,1R3UB@1224|Proteobacteria,2U497@28211|Alphaproteobacteria,43Z8T@69657|Hyphomonadaceae 28211|Alphaproteobacteria E I and II - - - - - - - - - - - - Aminotran_1_2 k59_1323234_1 199310.c2990 9.1e-101 310.0 COG0021@1|root,COG0021@2|Bacteria,1MUEY@1224|Proteobacteria,1RMWP@1236|Gammaproteobacteria,3XNP4@561|Escherichia 1236|Gammaproteobacteria G Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate tktA GO:0003674,GO:0003824,GO:0004802,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009987,GO:0016740,GO:0016744,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046496,GO:0051156,GO:0051186,GO:0055086,GO:0071704,GO:0072524,GO:1901135,GO:1901360,GO:1901564 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 - - iECABU_c1320.ECABU_c27750,iLF82_1304.LF82_2271,iNRG857_1313.NRG857_12300,iSDY_1059.SDY_3141,iYL1228.KPN_02799,ic_1306.c2990 Transket_pyr,Transketolase_C,Transketolase_N k59_1323234_2 316407.1799888 4.39e-65 206.0 COG0176@1|root,COG0176@2|Bacteria,1MWQ8@1224|Proteobacteria,1RMS0@1236|Gammaproteobacteria,3XMID@561|Escherichia 1236|Gammaproteobacteria F Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway talA GO:0003674,GO:0003824,GO:0004801,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009052,GO:0009117,GO:0009987,GO:0016740,GO:0016744,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046496,GO:0051156,GO:0051186,GO:0055086,GO:0071704,GO:0072524,GO:1901135,GO:1901360,GO:1901564 2.2.1.2 ko:K00616 ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007 R01827 RC00439,RC00604 ko00000,ko00001,ko00002,ko01000 - - iYL1228.KPN_02798 TAL_FSA k59_475309_1 1470591.BW41_01742 8.19e-80 258.0 COG2366@1|root,COG2366@2|Bacteria,1MVMH@1224|Proteobacteria,2TS4D@28211|Alphaproteobacteria,2K1S8@204457|Sphingomonadales 204457|Sphingomonadales S COG2366 Protein related to penicillin acylase - - - - - - - - - - - - Penicil_amidase k59_814486_1 382464.ABSI01000009_gene3980 9.29e-83 261.0 COG0633@1|root,COG3894@1|root,COG0633@2|Bacteria,COG3894@2|Bacteria 2|Bacteria C 2Fe-2S iron-sulfur cluster binding domain nqrF GO:0005575,GO:0005622,GO:0005623,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044424,GO:0044464,GO:0046858 - ko:K04755,ko:K08952,ko:K08953,ko:K08954 - - - - ko00000,ko00194 - - - DUF4445,Fer2 k59_25535_1 278963.ATWD01000001_gene2996 5.8e-23 90.1 COG2002@1|root,COG2002@2|Bacteria,3Y9C3@57723|Acidobacteria,2JK3K@204432|Acidobacteriia 204432|Acidobacteriia K SpoVT / AbrB like domain - - - - - - - - - - - - MazE_antitoxin k59_25535_2 1045855.DSC_07285 3.42e-26 100.0 COG3654@1|root,COG3654@2|Bacteria,1N1FW@1224|Proteobacteria,1SFPB@1236|Gammaproteobacteria,1X6TD@135614|Xanthomonadales 135614|Xanthomonadales S Fic/DOC family - - - ko:K07341 - - - - ko00000,ko02048 - - - Fic k59_589864_1 1121948.AUAC01000003_gene2833 5.66e-13 65.9 COG5454@1|root,COG5454@2|Bacteria,1NGEG@1224|Proteobacteria,2UJHR@28211|Alphaproteobacteria,43YUS@69657|Hyphomonadaceae 28211|Alphaproteobacteria S Protein of unknown function (DUF1467) - - - - - - - - - - - - DUF1467 k59_589864_3 1122137.AQXF01000002_gene125 1.05e-204 582.0 COG0595@1|root,COG0595@2|Bacteria,1MUGV@1224|Proteobacteria,2TQTR@28211|Alphaproteobacteria 28211|Alphaproteobacteria H hydrolase of the metallo-beta-lactamase superfamily rnjA - - ko:K12574 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - Lactamase_B,Lactamase_B_2,RMMBL k59_1494909_2 997346.HMPREF9374_2168 5.71e-09 59.3 COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,1UWKD@1239|Firmicutes,4I2MY@91061|Bacilli,27CPY@186824|Thermoactinomycetaceae 91061|Bacilli K helix_turn_helix, arabinose operon control protein - - - - - - - - - - - - HTH_18 k59_703143_1 1128421.JAGA01000002_gene1443 3.49e-28 115.0 COG3808@1|root,COG3808@2|Bacteria,2NNK9@2323|unclassified Bacteria 2|Bacteria C pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for hppA - 3.6.1.1 ko:K15987 ko00190,map00190 - - - ko00000,ko00001,ko01000 3.A.10.1 - - H_PPase k59_365154_1 469008.B21_01630 4.62e-106 308.0 COG0437@1|root,COG0437@2|Bacteria,1R5IV@1224|Proteobacteria,1RR1Z@1236|Gammaproteobacteria,3XQ9N@561|Escherichia 1236|Gammaproteobacteria C 4 iron, 4 sulfur cluster binding ydhX GO:0005575,GO:0005623,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0044464 - ko:K08353 ko00920,ko01120,map00920,map01120 - R10149 RC02823 ko00000,ko00001,ko02000 5.A.3.5 - - Fer4_11,Fer4_3,Fer4_7 k59_365154_2 316407.1742750 7.6e-110 320.0 COG4117@1|root,COG4117@2|Bacteria,1R4HB@1224|Proteobacteria,1RSIU@1236|Gammaproteobacteria,3XQV0@561|Escherichia 1236|Gammaproteobacteria C respiratory electron transport chain ydhU GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K08354 ko00920,ko01120,map00920,map01120 - R10149 RC02823 ko00000,ko00001,ko02000 5.A.3.5 - - Ni_hydr_CYTB k59_250637_2 1449068.JMLQ01000006_gene1616 4.9e-12 69.3 COG3653@1|root,COG3653@2|Bacteria,2GKMK@201174|Actinobacteria,4FUZR@85025|Nocardiaceae 201174|Actinobacteria Q COG3653 N-acyl-D-aspartate D-glutamate deacylase - - - - - - - - - - - - Amidohydro_1,Amidohydro_3 k59_365160_1 1236959.BAMT01000002_gene1882 5.04e-08 59.3 2DPC5@1|root,331GN@2|Bacteria,1NCRC@1224|Proteobacteria,2VVUT@28216|Betaproteobacteria,2KPAF@206350|Nitrosomonadales 206350|Nitrosomonadales S Domain of unknown function (DUF4124) - - - - - - - - - - - - DUF4124 k59_83929_2 1463921.JODF01000005_gene6175 1.82e-10 63.2 COG0500@1|root,COG0500@2|Bacteria,2I2Y4@201174|Actinobacteria 201174|Actinobacteria Q o-methyltransferase - - - - - - - - - - - - Methyltransf_2 k59_874705_1 1387312.BAUS01000007_gene2408 1.52e-34 123.0 COG3832@1|root,COG3832@2|Bacteria,1RD0P@1224|Proteobacteria,2VSQ4@28216|Betaproteobacteria,2KMU2@206350|Nitrosomonadales 206350|Nitrosomonadales S Activator of Hsp90 ATPase homolog 1-like protein - - - - - - - - - - - - AHSA1 k59_874705_2 1380391.JIAS01000015_gene314 9.98e-31 112.0 COG0640@1|root,COG0640@2|Bacteria,1N10H@1224|Proteobacteria,2UBRH@28211|Alphaproteobacteria,2JU0I@204441|Rhodospirillales 204441|Rhodospirillales K helix_turn_helix, Arsenical Resistance Operon Repressor - - - - - - - - - - - - HTH_20 k59_1496151_2 398511.BpOF4_06085 3.39e-23 109.0 COG1404@1|root,COG1404@2|Bacteria,1TQ2M@1239|Firmicutes,4HBYC@91061|Bacilli,1ZPV5@1386|Bacillus 91061|Bacilli O Belongs to the peptidase S8 family - - 3.4.21.62 ko:K01342,ko:K13277 ko02024,map02024 - - - ko00000,ko00001,ko01000,ko01002,ko03110 - - - A2M_N,CW_binding_2,Peptidase_S8,SLH k59_928345_1 237727.NAP1_02390 1.15e-197 587.0 COG4774@1|root,COG4774@2|Bacteria,1NMCN@1224|Proteobacteria,2U1C8@28211|Alphaproteobacteria,2K263@204457|Sphingomonadales 204457|Sphingomonadales P TonB-dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_928345_2 1042377.AFPJ01000008_gene1996 1.98e-84 254.0 COG1335@1|root,COG1335@2|Bacteria,1NZJ1@1224|Proteobacteria,1SA73@1236|Gammaproteobacteria,46APU@72275|Alteromonadaceae 1236|Gammaproteobacteria Q Isochorismatase family - - 3.5.1.107 ko:K13995 ko00760,ko01120,map00760,map01120 M00622 R03540 RC00950 ko00000,ko00001,ko00002,ko01000 - - - Isochorismatase k59_1098163_1 1173701.A0A066X4N1 6.19e-06 53.5 COG2072@1|root,KOG1399@2759|Eukaryota,38XB6@33154|Opisthokonta,3P0D7@4751|Fungi,3QQ19@4890|Ascomycota,21262@147550|Sordariomycetes,1EYX3@1028384|Glomerellales 4751|Fungi Q Belongs to the FMO family - - 1.14.13.8 ko:K00485 ko00982,ko01120,map00982,map01120 - R08266 RC02233 ko00000,ko00001,ko01000 - - - FMO-like k59_194490_1 983544.Lacal_2388 7.77e-43 159.0 COG4206@1|root,COG4206@2|Bacteria,4PKF2@976|Bacteroidetes,1IJ8K@117743|Flavobacteriia 976|Bacteroidetes H receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - CarbopepD_reg_2,Plug,TonB_dep_Rec k59_758556_1 1122137.AQXF01000003_gene2443 2.13e-117 350.0 COG1838@1|root,COG1951@1|root,COG1838@2|Bacteria,COG1951@2|Bacteria,1MUV9@1224|Proteobacteria,2TT46@28211|Alphaproteobacteria 28211|Alphaproteobacteria C Catalyzes the reversible hydration of fumarate to (S)- malate fumA GO:0003674,GO:0003824,GO:0004333,GO:0005488,GO:0005515,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016860,GO:0016862,GO:0016999,GO:0017144,GO:0019752,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0048037,GO:0050163,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0071704,GO:0072350 4.2.1.2 ko:K01676 ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374 R01082 RC00443 ko00000,ko00001,ko00002,ko01000 - - - Fumerase,Fumerase_C k59_1382807_1 1131269.AQVV01000018_gene1931 2.01e-27 108.0 COG1005@1|root,COG1005@2|Bacteria 2|Bacteria C quinone binding nuoH - 1.6.5.3 ko:K00337 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - NADHdh k59_928360_2 247633.GP2143_06714 1.97e-78 239.0 COG1011@1|root,COG1011@2|Bacteria,1QZ94@1224|Proteobacteria,1RZCU@1236|Gammaproteobacteria 1236|Gammaproteobacteria S HAD-hyrolase-like - - - ko:K07025 - - - - ko00000 - - - HAD_2 k59_1044497_1 1439940.BAY1663_02635 3.28e-30 118.0 COG0223@1|root,COG0223@2|Bacteria,1MU4Q@1224|Proteobacteria,1RP1T@1236|Gammaproteobacteria 1236|Gammaproteobacteria J Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus fmt GO:0003674,GO:0003824,GO:0004479,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006413,GO:0006418,GO:0006431,GO:0006464,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016741,GO:0016742,GO:0019538,GO:0019752,GO:0019988,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036211,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071951,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 2.1.2.9 ko:K00604 ko00670,ko00970,map00670,map00970 - R03940 RC00026,RC00165 ko00000,ko00001,ko01000 - - iECABU_c1320.ECABU_c37050,iECUMN_1333.ECUMN_3761,ic_1306.c4048 Formyl_trans_C,Formyl_trans_N k59_366450_1 247633.GP2143_07479 1.88e-121 365.0 COG0493@1|root,COG1143@1|root,COG0493@2|Bacteria,COG1143@2|Bacteria,1MU2H@1224|Proteobacteria,1RREP@1236|Gammaproteobacteria,1J5XD@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster - - - - - - - - - - - - Fer4_20,Fer4_7,NADH_4Fe-4S,Pyr_redox_2 k59_1608636_1 436308.Nmar_0088 3.18e-115 356.0 COG1201@1|root,arCOG00557@2157|Archaea,41S8P@651137|Thaumarchaeota 651137|Thaumarchaeota L DEAD/H associated - - - ko:K03724 - - - - ko00000,ko01000,ko03400 - - - DEAD,DEAD_assoc,Helicase_C k59_531755_1 1249627.D779_1450 6.52e-28 118.0 COG2304@1|root,COG2304@2|Bacteria,1MW51@1224|Proteobacteria,1RMD3@1236|Gammaproteobacteria,1WWHI@135613|Chromatiales 135613|Chromatiales S von Willebrand factor, type A - - - ko:K07114 - - - - ko00000,ko02000 1.A.13.2.2,1.A.13.2.3 - - TPR_1,TPR_16,VWA_2 k59_984006_1 316407.85676061 3.58e-66 209.0 COG0765@1|root,COG0765@2|Bacteria,1MV3I@1224|Proteobacteria,1RPJR@1236|Gammaproteobacteria,3XMT2@561|Escherichia 1236|Gammaproteobacteria P amino-acid ABC transporter permease protein YhdY yhdY GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 - ko:K02029,ko:K09971,ko:K10002,ko:K10037 ko02010,ko02020,map02010,map02020 M00227,M00230,M00232,M00236 - - ko00000,ko00001,ko00002,ko02000 3.A.1.3,3.A.1.3.18,3.A.1.3.19,3.A.1.3.2,3.A.1.3.4,3.A.1.3.7,3.A.1.3.8 - - BPD_transp_1 k59_984006_2 199310.c4035 2.16e-34 127.0 COG4597@1|root,COG4597@2|Bacteria,1MV0S@1224|Proteobacteria,1RN6V@1236|Gammaproteobacteria,3XNNW@561|Escherichia 1236|Gammaproteobacteria P amino-acid ABC transporter permease protein YhdX aapQ GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K09970 ko02010,map02010 M00232 - - ko00000,ko00001,ko00002,ko02000 3.A.1.3.18,3.A.1.3.7,3.A.1.3.8 - - BPD_transp_1 k59_476221_1 1248917.ANFX01000032_gene993 1.59e-34 123.0 COG0864@1|root,COG0864@2|Bacteria,1RDN6@1224|Proteobacteria,2U61K@28211|Alphaproteobacteria,2K4CQ@204457|Sphingomonadales 204457|Sphingomonadales K Transcriptional regulator - - - - - - - - - - - - NikR_C,RHH_1 k59_476221_2 983920.Y88_3089 2.71e-75 238.0 COG3665@1|root,COG3665@2|Bacteria,1N2KR@1224|Proteobacteria,2TSBV@28211|Alphaproteobacteria,2K1Q9@204457|Sphingomonadales 204457|Sphingomonadales S Domain of unknown function (DUF1989) - - - ko:K09967 - - - - ko00000 - - - DUF1989 k59_1044509_3 1121405.dsmv_1320 4.47e-09 58.2 COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MU0R@1224|Proteobacteria,42NDJ@68525|delta/epsilon subdivisions,2WJSH@28221|Deltaproteobacteria,2MIZ3@213118|Desulfobacterales 28221|Deltaproteobacteria G Belongs to the PEP-utilizing enzyme family ppdK - 2.7.9.1 ko:K01006 ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200 M00169,M00171,M00172,M00173 R00206 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - PEP-utilizers,PEP-utilizers_C,PPDK_N k59_366467_1 1159870.KB907784_gene2338 1.52e-21 88.6 COG2009@1|root,COG2009@2|Bacteria,1RIGZ@1224|Proteobacteria,2VSEG@28216|Betaproteobacteria 28216|Betaproteobacteria C Succinate dehydrogenase cytochrome b556 subunit sdhC - - ko:K00241 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00149,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002 - - - Sdh_cyt k59_366467_2 159087.Daro_2864 9.71e-42 140.0 COG2142@1|root,COG2142@2|Bacteria,1MZR9@1224|Proteobacteria,2VSJN@28216|Betaproteobacteria,2KWK5@206389|Rhodocyclales 206389|Rhodocyclales C Succinate dehydrogenase, hydrophobic - - - ko:K00242 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00149,M00173 R02164 RC00045 ko00000,ko00001,ko00002 - - - Sdh_cyt k59_366467_3 522306.CAP2UW1_2384 1.36e-09 58.2 COG1053@1|root,COG1053@2|Bacteria,1MU5M@1224|Proteobacteria,2VHM6@28216|Betaproteobacteria,1KPP3@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria C Belongs to the FAD-dependent oxidoreductase 2 family. FRD SDH subfamily sdhA GO:0000104,GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009055,GO:0009060,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016627,GO:0016999,GO:0017144,GO:0019752,GO:0022900,GO:0032991,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0045273,GO:0045274,GO:0045281,GO:0045282,GO:0045333,GO:0048037,GO:0050660,GO:0050662,GO:0055114,GO:0070469,GO:0070470,GO:0071704,GO:0071944,GO:0072350,GO:0097159,GO:0098796,GO:0098797,GO:0098803,GO:1901265,GO:1901363,GO:1902494,GO:1990204 1.3.5.1,1.3.5.4 ko:K00239 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134 M00009,M00011,M00149,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,Succ_DH_flav_C k59_1663808_1 1382306.JNIM01000001_gene767 9.09e-63 209.0 COG0364@1|root,COG0364@2|Bacteria,2G5MB@200795|Chloroflexi 200795|Chloroflexi G Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone zwf - 1.1.1.363,1.1.1.49 ko:K00036 ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230 M00004,M00006,M00008 R00835,R02736,R10907 RC00001,RC00066 ko00000,ko00001,ko00002,ko01000,ko04147 - - - G6PD_C,G6PD_N k59_704367_1 765914.ThisiDRAFT_0890 1.8e-36 130.0 COG3168@1|root,COG3168@2|Bacteria,1RI6V@1224|Proteobacteria,1S6VJ@1236|Gammaproteobacteria,1WYAC@135613|Chromatiales 135613|Chromatiales NU pilus assembly protein PilP - - - ko:K02665 - - - - ko00000,ko02035,ko02044 - - - PilP k59_483449_1 557598.LHK_03240 1.95e-45 160.0 COG0593@1|root,COG0593@2|Bacteria,1MU5H@1224|Proteobacteria,2VHH0@28216|Betaproteobacteria,2KPIA@206351|Neisseriales 206351|Neisseriales L it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids dnaA - - ko:K02313 ko02020,ko04112,map02020,map04112 - - - ko00000,ko00001,ko03032,ko03036 - - - Bac_DnaA,Bac_DnaA_C,DnaA_N k59_885139_1 1122137.AQXF01000001_gene3213 4.58e-88 269.0 COG0626@1|root,COG0626@2|Bacteria,1MU57@1224|Proteobacteria,2TTMF@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Catalyzes the formation of L-homocysteine from O- succinyl-L-homoserine (OSHS) and hydrogen sulfide metZ GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0003962,GO:0004123,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0016829,GO:0016846,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.5.1.48 ko:K01739,ko:K10764 ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00270,map00450,map00920,map01100,map01110,map01130,map01230 M00017 R00999,R01288,R02508,R03217,R03260,R04944,R04945,R04946 RC00020,RC00056,RC00069,RC00420,RC02848,RC02866 ko00000,ko00001,ko00002,ko01000 - - - Cys_Met_Meta_PP k59_885139_2 570967.JMLV01000002_gene1515 2.61e-34 122.0 COG2967@1|root,COG2967@2|Bacteria,1MZ2Z@1224|Proteobacteria,2U9JM@28211|Alphaproteobacteria,2JSX8@204441|Rhodospirillales 204441|Rhodospirillales P protein affecting Mg2 Co2 transport apaG - - ko:K06195 - - - - ko00000 - - - DUF525 k59_1274395_2 1446473.JHWH01000024_gene2841 6.87e-38 145.0 COG1473@1|root,COG1473@2|Bacteria,1MX6N@1224|Proteobacteria,2TRSE@28211|Alphaproteobacteria,2PX8K@265|Paracoccus 28211|Alphaproteobacteria S Peptidase family M20/M25/M40 - - - ko:K12941 - - - - ko00000,ko01002 - - - M20_dimer,Peptidase_M20 k59_1105856_1 1283300.ATXB01000001_gene1189 1.26e-23 101.0 COG3211@1|root,COG3211@2|Bacteria,1R7E2@1224|Proteobacteria,1SCSQ@1236|Gammaproteobacteria,1XGF9@135618|Methylococcales 135618|Methylococcales S Bacterial protein of unknown function (DUF839) - - - - - - - - - - - - DUF839 k59_92874_1 1247963.JPHU01000001_gene2058 2.71e-07 59.7 COG0477@1|root,COG0477@2|Bacteria,1QU36@1224|Proteobacteria,2TVXA@28211|Alphaproteobacteria 28211|Alphaproteobacteria EGP Major Facilitator Superfamily - - - ko:K07552,ko:K18552 - - - - br01600,ko00000,ko01504,ko02000 2.A.1.2,2.A.1.2.3 - - MFS_1 k59_92874_2 330084.JNYZ01000034_gene2799 1.45e-15 80.1 COG2843@1|root,COG2843@2|Bacteria 2|Bacteria M Bacterial capsule synthesis protein PGA_cap - - - ko:K07282 - - - - ko00000 - - - PGA_cap k59_824761_2 1157708.KB907460_gene1461 1.75e-89 273.0 COG3752@1|root,COG3752@2|Bacteria,1MXCP@1224|Proteobacteria,2VQHY@28216|Betaproteobacteria,4ADH5@80864|Comamonadaceae 28216|Betaproteobacteria S 3-oxo-5-alpha-steroid 4-dehydrogenase - - - - - - - - - - - - DUF1295 k59_1221203_1 158500.BV97_00972 5.51e-12 63.5 COG3476@1|root,COG3476@2|Bacteria,1MZC1@1224|Proteobacteria,2UBYB@28211|Alphaproteobacteria,2K4UV@204457|Sphingomonadales 204457|Sphingomonadales T Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog) bzrP - - ko:K05770 ko04080,ko04214,ko04979,ko05166,map04080,map04214,map04979,map05166 - - - ko00000,ko00001,ko02000 9.A.24 - - TspO_MBR k59_1221203_2 555793.WSK_4236 6.31e-33 115.0 COG2960@1|root,COG2960@2|Bacteria,1N725@1224|Proteobacteria,2UFEP@28211|Alphaproteobacteria,2K74V@204457|Sphingomonadales 204457|Sphingomonadales S Membrane fusogenic activity - - - ko:K09806 - - - - ko00000 - - - BMFP k59_428083_1 1117315.AHCA01000001_gene2368 2.46e-77 257.0 COG4773@1|root,COG4773@2|Bacteria,1QTT0@1224|Proteobacteria,1RNBT@1236|Gammaproteobacteria,2PZEK@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria P TonB dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_204348_1 1479237.JMLY01000001_gene2253 4.83e-71 222.0 COG1028@1|root,COG1028@2|Bacteria,1PEWK@1224|Proteobacteria,1RXZH@1236|Gammaproteobacteria 1236|Gammaproteobacteria IQ COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - - - - - - - - - - - adh_short_C2 k59_1221207_2 1123248.KB893359_gene1998 7.91e-38 144.0 COG4354@1|root,COG4354@2|Bacteria,4NFQW@976|Bacteroidetes,1IR0K@117747|Sphingobacteriia 976|Bacteroidetes G beta-glucosidase 2, glycosyl-hydrolase family 116 N-term - - 3.2.1.45 ko:K17108 ko00511,ko00600,ko01100,map00511,map00600,map01100 - R01498 RC00059,RC00451 ko00000,ko00001,ko01000 - GH116 - DUF608,Glyco_hydr_116N k59_1393391_1 371731.Rsw2DRAFT_3385 1.21e-155 445.0 COG2433@1|root,COG2433@2|Bacteria,1RJ1Q@1224|Proteobacteria,2U9U2@28211|Alphaproteobacteria 28211|Alphaproteobacteria K Transposase - - - - - - - - - - - - DDE_Tnp_IS66,DDE_Tnp_IS66_C,LZ_Tnp_IS66,zf-IS66 k59_1393391_2 443598.AUFA01000030_gene5929 1.89e-10 57.8 COG3436@1|root,COG3436@2|Bacteria,1RHDW@1224|Proteobacteria,2U7TH@28211|Alphaproteobacteria,3K05R@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria L IS66 Orf2 like protein - - - ko:K07484 - - - - ko00000 - - - TnpB_IS66 k59_262002_1 1123367.C666_07495 3.79e-76 251.0 COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,2VI87@28216|Betaproteobacteria,2KVBJ@206389|Rhodocyclales 206389|Rhodocyclales L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate - - - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - ABC_tran k59_601621_1 1038869.AXAN01000020_gene4086 4.12e-48 164.0 COG1877@1|root,COG1877@2|Bacteria,1RGY2@1224|Proteobacteria,2VRQ8@28216|Betaproteobacteria,1K3QP@119060|Burkholderiaceae 28216|Betaproteobacteria G Removes the phosphate from trehalose 6-phosphate to produce free trehalose otsB - 3.1.3.12 ko:K01087 ko00500,ko01100,map00500,map01100 - R02778 RC00017 ko00000,ko00001,ko01000 - - - Trehalose_PPase k59_601621_2 1156919.QWC_31006 5.49e-23 97.1 COG1473@1|root,COG1473@2|Bacteria,1MUIV@1224|Proteobacteria,2VIS0@28216|Betaproteobacteria,3T5XE@506|Alcaligenaceae 28216|Betaproteobacteria S Metal-dependent amidase aminoacylase carboxypeptidase - - - - - - - - - - - - M20_dimer,Peptidase_M20 k59_1105865_1 754477.Q7C_1499 7.74e-84 261.0 COG2908@1|root,COG2908@2|Bacteria,1MVKD@1224|Proteobacteria,1RQIA@1236|Gammaproteobacteria,4605X@72273|Thiotrichales 72273|Thiotrichales S Calcineurin-like phosphoesterase superfamily domain - - - - - - - - - - - - Metallophos_2 k59_1105865_2 1121106.JQKB01000005_gene2221 2.15e-39 147.0 COG2307@1|root,COG2307@2|Bacteria,1MVZK@1224|Proteobacteria,2TQUM@28211|Alphaproteobacteria,2JQN9@204441|Rhodospirillales 204441|Rhodospirillales S A predicted alpha-helical domain with a conserved ER motif. - - - - - - - - - - - - Alpha-E k59_935996_1 1267534.KB906759_gene1816 1.15e-36 142.0 COG3712@1|root,COG3712@2|Bacteria,3Y772@57723|Acidobacteria 57723|Acidobacteria PT FecR protein - - - - - - - - - - - - FecR k59_1506397_1 1122137.AQXF01000006_gene701 5.46e-95 298.0 COG1449@1|root,COG1449@2|Bacteria,1R51R@1224|Proteobacteria 1224|Proteobacteria G Belongs to the glycosyl hydrolase 57 family - - - - - - - - - - - - Glyco_hydro_57 k59_428106_1 1042375.AFPL01000008_gene3144 6.04e-88 273.0 COG0773@1|root,COG0773@2|Bacteria,1MV68@1224|Proteobacteria,1RN88@1236|Gammaproteobacteria,465HW@72275|Alteromonadaceae 1236|Gammaproteobacteria M Belongs to the MurCDEF family murC GO:0000166,GO:0000270,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008763,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0017076,GO:0030203,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034645,GO:0035639,GO:0036094,GO:0042546,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0046872,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.3.2.8 ko:K01924 ko00471,ko00550,ko01100,map00471,map00550,map01100 - R03193 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - iECP_1309.ECP_0093 Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_1563790_1 395495.Lcho_0801 9.21e-07 55.5 COG0583@1|root,COG0583@2|Bacteria,1N663@1224|Proteobacteria,2VIKU@28216|Betaproteobacteria,1KM6C@119065|unclassified Burkholderiales 28216|Betaproteobacteria K LysR substrate binding domain - - - - - - - - - - - - HTH_1,LysR_substrate k59_1331369_1 1123023.JIAI01000001_gene7780 5.45e-46 164.0 COG3386@1|root,COG3386@2|Bacteria 2|Bacteria G gluconolactonase activity - - 3.1.1.17 ko:K01053,ko:K02352 ko00030,ko00053,ko00930,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,map00030,map00053,map00930,map01100,map01110,map01120,map01130,map01200,map01220 M00129 R01519,R02933,R03751 RC00537,RC00983 ko00000,ko00001,ko00002,ko01000,ko04147 - - - SGL k59_1331369_2 373994.Riv7116_5346 4.56e-48 174.0 COG0737@1|root,COG2374@1|root,COG2931@1|root,COG3391@1|root,COG4222@1|root,COG0737@2|Bacteria,COG2374@2|Bacteria,COG2931@2|Bacteria,COG3391@2|Bacteria,COG4222@2|Bacteria,1G0YK@1117|Cyanobacteria,1HM71@1161|Nostocales 1117|Cyanobacteria Q phosphatase - - 3.1.3.8 ko:K01083,ko:K07004 ko00562,map00562 - R03371 RC00078 ko00000,ko00001,ko01000 - - - 5_nucleotid_C,Calx-beta,DUF4114,Exo_endo_phos,LTD,Phytase-like,VPEP k59_1105878_1 1122137.AQXF01000002_gene58 4.8e-102 296.0 COG1846@1|root,COG1846@2|Bacteria,1RA1V@1224|Proteobacteria,2U5W6@28211|Alphaproteobacteria 28211|Alphaproteobacteria K Transcriptional regulator mucS - - - - - - - - - - - HTH_27 k59_1332345_1 350058.Mvan_3244 9.62e-35 129.0 COG0500@1|root,COG2226@2|Bacteria,2GJUF@201174|Actinobacteria,236M1@1762|Mycobacteriaceae 201174|Actinobacteria Q Catalyzes the methylation of the lipid moiety of the intermediate compounds phthiotriol and glycosylated phenolphthiotriol dimycoserosates to form phthiocerol dimycocerosates (DIM A) and glycosylated phenolphthiocerol dimycocerosates (PGL) - - - - - - - - - - - - Methyltransf_11,Methyltransf_25 k59_1332345_2 509635.N824_24065 4.98e-10 63.5 COG3345@1|root,COG3345@2|Bacteria,4NFSU@976|Bacteroidetes,1J0QP@117747|Sphingobacteriia 976|Bacteroidetes G Alpha galactosidase A - - 3.2.1.22 ko:K07407 ko00052,ko00561,ko00600,ko00603,map00052,map00561,map00600,map00603 - R01101,R01103,R01104,R01194,R01329,R02926,R03634,R04019,R04470,R05549,R05961,R06091 RC00049,RC00059,RC00451 ko00000,ko00001,ko01000 - - - He_PIG,He_PIG_assoc,Melibiase_2,Melibiase_2_C k59_147875_1 548479.HMPREF0573_11807 4.97e-43 155.0 COG0624@1|root,COG0624@2|Bacteria,2GM84@201174|Actinobacteria,4D34Y@85005|Actinomycetales 201174|Actinobacteria E Peptidase dimerization domain protein argE - - - - - - - - - - - M20_dimer,Peptidase_M20 k59_262943_1 204773.HEAR1180 6.64e-26 111.0 COG1529@1|root,COG1529@2|Bacteria,1QTTJ@1224|Proteobacteria,2VHB9@28216|Betaproteobacteria,472M9@75682|Oxalobacteraceae 28216|Betaproteobacteria C Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain iorB - 1.3.99.16 ko:K07303 - - - - ko00000,ko01000 - - - Ald_Xan_dh_C,Ald_Xan_dh_C2 k59_539548_1 1121100.JCM6294_1996 2.03e-06 57.8 COG0475@1|root,COG0589@1|root,COG0475@2|Bacteria,COG0589@2|Bacteria,4NF11@976|Bacteroidetes,2FN0I@200643|Bacteroidia,4AM9K@815|Bacteroidaceae 976|Bacteroidetes PT Psort location CytoplasmicMembrane, score 10.00 ybaL_1 - - - - - - - - - - - Na_H_Exchanger,Usp k59_654785_1 640081.Dsui_0048 5.46e-71 224.0 COG0152@1|root,COG0152@2|Bacteria,1MUR9@1224|Proteobacteria,2VGZK@28216|Betaproteobacteria,2KUQQ@206389|Rhodocyclales 206389|Rhodocyclales F Belongs to the SAICAR synthetase family purC - 6.3.2.6 ko:K01923 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04591 RC00064,RC00162 ko00000,ko00001,ko00002,ko01000 - - - SAICAR_synt k59_1332362_1 498211.CJA_3656 1.22e-79 246.0 COG0596@1|root,COG0596@2|Bacteria,1MWW8@1224|Proteobacteria,1RMKF@1236|Gammaproteobacteria,1FFY0@10|Cellvibrio 1236|Gammaproteobacteria E Alpha/beta hydrolase family pip - 3.4.11.5 ko:K01259 ko00330,map00330 - R00135 - ko00000,ko00001,ko01000,ko01002 - - - Abhydrolase_1 k59_1332363_1 388399.SSE37_07713 3.77e-12 66.2 COG0767@1|root,COG0767@2|Bacteria,1MVPN@1224|Proteobacteria,2TSGS@28211|Alphaproteobacteria 28211|Alphaproteobacteria Q ABC-type transport system involved in resistance to organic solvents permease component mlaE - - ko:K02066 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - MlaE k59_1332363_2 1366050.N234_05980 5.62e-25 102.0 COG1024@1|root,COG1024@2|Bacteria,1MVQN@1224|Proteobacteria,2VHE9@28216|Betaproteobacteria,1KCKQ@119060|Burkholderiaceae 28216|Betaproteobacteria I Enoyl-CoA hydratase/isomerase - - 5.3.3.18 ko:K15866 ko00360,ko01120,map00360,map01120 - R09837,R09839 RC00004,RC00326,RC02689,RC03003 ko00000,ko00001,ko01000 - - - ECH_1 k59_205679_1 1041146.ATZB01000007_gene2877 7.56e-06 47.4 COG2010@1|root,COG2010@2|Bacteria,1N0EF@1224|Proteobacteria,2UCVE@28211|Alphaproteobacteria 28211|Alphaproteobacteria C Cytochrome c mono- and diheme variants - - - - - - - - - - - - - k59_205679_2 1280947.HY30_06890 3.75e-09 56.6 COG1525@1|root,COG1525@2|Bacteria,1QYDH@1224|Proteobacteria,2TXPF@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Excalibur calcium-binding domain - - - - - - - - - - - - Excalibur k59_825892_1 1347368.HG964408_gene6950 4.42e-29 120.0 COG0642@1|root,COG2199@1|root,COG3300@1|root,COG2205@2|Bacteria,COG3300@2|Bacteria,COG3706@2|Bacteria,1UEIC@1239|Firmicutes,4HDD8@91061|Bacilli,1ZAQA@1386|Bacillus 91061|Bacilli T Histidine kinase - - - - - - - - - - - - GAF,GAF_2,HATPase_c,HisKA,MHYT,PAS,PAS_4,PAS_9,Response_reg k59_429043_2 867845.KI911784_gene646 1.22e-41 152.0 COG0827@1|root,COG0827@2|Bacteria,2GAI2@200795|Chloroflexi,3769G@32061|Chloroflexia 32061|Chloroflexia L N-6 DNA Methylase - - - - - - - - - - - - N6_Mtase k59_992540_1 92637.XP_007812243.1 1.01e-51 179.0 COG0520@1|root,KOG2142@2759|Eukaryota,38F30@33154|Opisthokonta,3NXCU@4751|Fungi,3QPCH@4890|Ascomycota,2147Z@147550|Sordariomycetes,3TGF8@5125|Hypocreales,3FZXA@34397|Clavicipitaceae 4751|Fungi H Sulfurates the molybdenum cofactor. Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom in active form - - 2.8.1.9 ko:K15631 ko00790,map00790 - R11583 - ko00000,ko00001,ko01000 - - - Aminotran_5 k59_1106855_1 1296415.JACC01000041_gene45 5.49e-102 340.0 COG3209@1|root,COG3209@2|Bacteria,4NE5D@976|Bacteroidetes,1HYTK@117743|Flavobacteriia,2YHFX@290174|Aquimarina 976|Bacteroidetes M RHS repeat-associated core domain - - - - - - - - - - - - - k59_1106855_2 1380600.AUYN01000011_gene948 1.39e-26 118.0 COG3209@1|root,COG3209@2|Bacteria,4NHYT@976|Bacteroidetes,1HYFY@117743|Flavobacteriia 976|Bacteroidetes M TIGRFAM YD repeat - - - - - - - - - - - - - k59_603004_1 1116375.VEJY3_19626 4.07e-07 60.1 COG4102@1|root,COG4102@2|Bacteria,1MX4R@1224|Proteobacteria,1RR99@1236|Gammaproteobacteria,1XTSR@135623|Vibrionales 135623|Vibrionales S Protein of unknown function (DUF1501) - - - - - - - - - - - - DUF1501 k59_603004_2 248742.XP_005643662.1 6.94e-12 65.5 KOG0632@1|root,KOG0632@2759|Eukaryota,37RCM@33090|Viridiplantae 33090|Viridiplantae P glutathione gamma-glutamylcysteinyltransferase PCS1 GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005507,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006518,GO:0006725,GO:0006790,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006950,GO:0006952,GO:0008150,GO:0008152,GO:0008324,GO:0008490,GO:0008509,GO:0009056,GO:0009058,GO:0009605,GO:0009607,GO:0009617,GO:0009987,GO:0010035,GO:0010038,GO:0015075,GO:0015103,GO:0015105,GO:0015291,GO:0015318,GO:0015399,GO:0015405,GO:0015446,GO:0015698,GO:0015700,GO:0016043,GO:0016143,GO:0016145,GO:0016462,GO:0016740,GO:0016746,GO:0016755,GO:0016756,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019439,GO:0019748,GO:0019757,GO:0019759,GO:0019760,GO:0019762,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0033036,GO:0033037,GO:0033554,GO:0034220,GO:0034641,GO:0042221,GO:0042343,GO:0042344,GO:0042430,GO:0042436,GO:0042545,GO:0042623,GO:0042625,GO:0042626,GO:0042742,GO:0043043,GO:0043167,GO:0043169,GO:0043207,GO:0043225,GO:0043436,GO:0043492,GO:0043603,GO:0043604,GO:0044237,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044273,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0044550,GO:0045229,GO:0046483,GO:0046685,GO:0046686,GO:0046700,GO:0046870,GO:0046872,GO:0046914,GO:0046937,GO:0046938,GO:0050896,GO:0051179,GO:0051234,GO:0051641,GO:0051704,GO:0051707,GO:0051716,GO:0052386,GO:0052482,GO:0052542,GO:0052543,GO:0052544,GO:0052545,GO:0055085,GO:0070727,GO:0071554,GO:0071555,GO:0071704,GO:0071840,GO:0090662,GO:0098542,GO:0098655,GO:0098656,GO:0098660,GO:0099131,GO:0099132,GO:0099133,GO:0140096,GO:1901135,GO:1901136,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901657,GO:1901658,GO:1901683,GO:1901684 2.3.2.15 ko:K05941 - - - - ko00000,ko01000 - - - Phytochelatin,Phytochelatin_C k59_429048_1 1122137.AQXF01000002_gene501 1.56e-70 218.0 COG1189@1|root,COG1189@2|Bacteria,1MWP5@1224|Proteobacteria,2TRW9@28211|Alphaproteobacteria 28211|Alphaproteobacteria J hemolysin tlyA - 2.1.1.226,2.1.1.227 ko:K06442 - - - - ko00000,ko01000,ko03009 - - - FtsJ,S4 k59_429048_2 1122137.AQXF01000002_gene502 7.65e-20 88.6 COG1154@1|root,COG1154@2|Bacteria,1MUSJ@1224|Proteobacteria,2TRDD@28211|Alphaproteobacteria 28211|Alphaproteobacteria H Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) dxs - 2.2.1.7 ko:K01662 ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130 M00096 R05636 RC00032 ko00000,ko00001,ko00002,ko01000 - - - DXP_synthase_N,Transket_pyr,Transketolase_C k59_825907_1 391603.FBALC1_17017 5.35e-39 140.0 COG0823@1|root,COG0823@2|Bacteria,4PMAE@976|Bacteroidetes,1HWTA@117743|Flavobacteriia 976|Bacteroidetes U Periplasmic component of the Tol biopolymer transport system - - - - - - - - - - - - PD40 k59_825907_2 1197477.IA57_05570 1.5e-55 186.0 COG0265@1|root,COG2234@1|root,COG0265@2|Bacteria,COG2234@2|Bacteria,4NFZR@976|Bacteroidetes,1HXXH@117743|Flavobacteriia 976|Bacteroidetes O Peptidase m28 - - - - - - - - - - - - PD40,PDZ_2,Peptidase_M28 k59_1730426_1 991905.SL003B_3341 3.72e-40 151.0 COG4907@1|root,COG4907@2|Bacteria,1MXPY@1224|Proteobacteria,2TUBP@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Predicted membrane protein (DUF2207) - - - - - - - - - - - - DUF2207 k59_1445521_1 377629.TERTU_0866 3.18e-29 118.0 COG0340@1|root,COG1654@1|root,COG0340@2|Bacteria,COG1654@2|Bacteria,1MWCC@1224|Proteobacteria,1RNGC@1236|Gammaproteobacteria,2PNE7@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria K Biotin protein ligase C terminal domain birA GO:0000166,GO:0000976,GO:0000984,GO:0001017,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003824,GO:0004077,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0006082,GO:0006464,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009305,GO:0009374,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0017053,GO:0017076,GO:0017144,GO:0018130,GO:0018271,GO:0019538,GO:0019752,GO:0019842,GO:0030554,GO:0031406,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0032991,GO:0033218,GO:0033293,GO:0034641,GO:0035639,GO:0036094,GO:0036211,GO:0042364,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043565,GO:0043603,GO:0043604,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0046983,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901681,GO:1990837 6.3.4.15 ko:K03524 ko00780,ko01100,map00780,map01100 - R01074,R05145 RC00043,RC00070,RC00096,RC02896 ko00000,ko00001,ko01000,ko03000 - - - BPL_C,BPL_LplA_LipB,HTH_11 k59_767014_1 1430440.MGMSRv2_3255 2.02e-55 190.0 COG1884@1|root,COG2185@1|root,COG1884@2|Bacteria,COG2185@2|Bacteria,1MUXX@1224|Proteobacteria,2TQYC@28211|Alphaproteobacteria,2JP9C@204441|Rhodospirillales 204441|Rhodospirillales I Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly icmF - 5.4.99.2 ko:K01847 ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200 M00373,M00376,M00741 R00833 RC00395 ko00000,ko00001,ko00002,ko01000 - - - ArgK,B12-binding,MM_CoA_mutase k59_767014_2 457570.Nther_0428 2.34e-12 66.6 COG3404@1|root,COG3404@2|Bacteria,1V1X8@1239|Firmicutes,24JZM@186801|Clostridia 186801|Clostridia E Formiminotransferase-cyclodeaminase fchA - - - - - - - - - - - FTCD_C k59_1394545_1 236097.ADG881_3321 5.95e-71 220.0 COG0588@1|root,COG0588@2|Bacteria,1MUVE@1224|Proteobacteria,1RNCX@1236|Gammaproteobacteria,1XN15@135619|Oceanospirillales 135619|Oceanospirillales G Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily gpmA - 5.4.2.11 ko:K01834 ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko05230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map05230 M00001,M00002,M00003 R01518 RC00536 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - His_Phos_1 k59_205715_1 1458357.BG58_38220 8.66e-50 167.0 COG1651@1|root,COG1651@2|Bacteria,1RD39@1224|Proteobacteria,2VIHV@28216|Betaproteobacteria,1K1N6@119060|Burkholderiaceae 28216|Betaproteobacteria O Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process dsbC - 5.3.4.1 ko:K03981 - - - - ko00000,ko01000,ko02044,ko03110 3.A.7.11.1 - - DsbC_N,Thioredoxin_2 k59_1332419_1 7955.ENSDARP00000112010 7.76e-19 90.5 COG1028@1|root,KOG1208@2759|Eukaryota,38E7S@33154|Opisthokonta,3BE90@33208|Metazoa,3CTUW@33213|Bilateria,485H2@7711|Chordata,4918B@7742|Vertebrata,49YF5@7898|Actinopterygii 33208|Metazoa Q Dehydrogenase reductase SDR family member DHRS13 - - ko:K11169 - - - - ko00000,ko01000 - - - adh_short k59_1445529_1 1247963.JPHU01000021_gene29 4.88e-25 103.0 COG0659@1|root,COG0659@2|Bacteria,1MWDF@1224|Proteobacteria,2TT0G@28211|Alphaproteobacteria 28211|Alphaproteobacteria P COG0659 Sulfate permease and related transporters (MFS superfamily sulP - - ko:K03321 - - - - ko00000,ko02000 2.A.53.3 - - STAS,Sulfate_transp k59_1445529_2 1385517.N800_11785 2.8e-06 52.8 COG2353@1|root,COG2353@2|Bacteria,1R9XD@1224|Proteobacteria,1S24R@1236|Gammaproteobacteria,1X5Y6@135614|Xanthomonadales 135614|Xanthomonadales S Belongs to the UPF0312 family - - - - - - - - - - - - YceI k59_1782425_1 215803.DB30_5174 2.65e-17 87.4 COG3291@1|root,COG5492@1|root,COG3291@2|Bacteria,COG5492@2|Bacteria,1PEIB@1224|Proteobacteria,439WA@68525|delta/epsilon subdivisions,2X5AJ@28221|Deltaproteobacteria,2YWZV@29|Myxococcales 28221|Deltaproteobacteria N Chitobiase/beta-hexosaminidase C-terminal domain - - - - - - - - - - - - CHB_HEX_C_1 k59_1617913_1 1123037.AUDE01000021_gene2184 9.13e-90 279.0 COG0793@1|root,COG0793@2|Bacteria,4NEGV@976|Bacteroidetes,1HXSR@117743|Flavobacteriia 976|Bacteroidetes M Belongs to the peptidase S41A family ctp - 3.4.21.102 ko:K03797 - - - - ko00000,ko01000,ko01002 - - - PDZ_2,Peptidase_S41 k59_1564913_1 1187851.A33M_0449 7.77e-10 60.5 COG0491@1|root,COG0491@2|Bacteria,1MVC3@1224|Proteobacteria,2TUAZ@28211|Alphaproteobacteria,3FD25@34008|Rhodovulum 28211|Alphaproteobacteria S Metallo-beta-lactamase superfamily MA20_07390 - 3.1.2.6 ko:K01069 ko00620,map00620 - R01736 RC00004,RC00137 ko00000,ko00001,ko01000 - - - Lactamase_B k59_1564913_2 1117647.M5M_18710 5.04e-23 96.3 COG3007@1|root,COG3007@2|Bacteria,1MWCQ@1224|Proteobacteria,1RPPP@1236|Gammaproteobacteria,1J56E@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria I Involved in the final reduction of the elongation cycle of fatty acid synthesis (FAS II). Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP) fabV GO:0000166,GO:0003674,GO:0003824,GO:0004312,GO:0004318,GO:0005488,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0032787,GO:0036094,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0071704,GO:0072330,GO:0097159,GO:1901265,GO:1901363,GO:1901576 1.3.1.44,1.3.1.9 ko:K00209 ko00061,ko00650,ko01100,ko01120,ko01200,ko01212,map00061,map00650,map01100,map01120,map01200,map01212 M00083 R01171,R04429,R04724,R04955,R04958,R04961,R04966,R04969 RC00052,RC00076 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Eno-Rase_FAD_bd,Eno-Rase_NADH_b,Enoyl_reductase k59_94006_1 631362.Thi970DRAFT_02933 1.21e-51 181.0 COG0248@1|root,COG0248@2|Bacteria,1MV35@1224|Proteobacteria,1RN3V@1236|Gammaproteobacteria,1WWTY@135613|Chromatiales 135613|Chromatiales FP Belongs to the GppA Ppx family - - 3.6.1.11,3.6.1.40 ko:K01524 ko00230,map00230 - R03409 RC00002 ko00000,ko00001,ko01000 - - - Ppx-GppA k59_1617924_1 314285.KT71_17846 9.51e-140 420.0 COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,1RN2C@1236|Gammaproteobacteria,1J57S@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P cation transport ATPase actP - 3.6.3.54 ko:K17686 ko01524,ko04016,map01524,map04016 - R00086 RC00002 ko00000,ko00001,ko01000 3.A.3.5 - - E1-E2_ATPase,HMA,Hydrolase,YHS k59_1394574_1 983920.Y88_2738 6.25e-85 266.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2TQPG@28211|Alphaproteobacteria 28211|Alphaproteobacteria T COG2204 Response regulator containing CheY-like receiver AAA-type ATPase and DNA-binding domains hoxA - - ko:K19641 ko02020,map02020 M00772 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_205743_1 627192.SLG_09290 8.66e-10 57.0 COG5485@1|root,COG5485@2|Bacteria,1RHA7@1224|Proteobacteria,2V6FV@28211|Alphaproteobacteria,2KAHP@204457|Sphingomonadales 204457|Sphingomonadales S SnoaL-like polyketide cyclase - - - - - - - - - - - - SnoaL k59_205743_2 911045.PSE_p0084 1.23e-54 175.0 2DMIA@1|root,32RRC@2|Bacteria,1N1A9@1224|Proteobacteria,2UC0G@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_205743_3 1122137.AQXF01000003_gene2417 2.15e-27 111.0 COG2234@1|root,COG2234@2|Bacteria,1NVWC@1224|Proteobacteria 1224|Proteobacteria S Peptidase family M28 - - - - - - - - - - - - Peptidase_M28 k59_1054464_1 199310.c3973 1.34e-108 346.0 COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,1MU7B@1224|Proteobacteria,1RN2W@1236|Gammaproteobacteria,3XMUK@561|Escherichia 1236|Gammaproteobacteria E glutamate synthase gltB GO:0003674,GO:0003824,GO:0004355,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006541,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0015930,GO:0016053,GO:0016491,GO:0016638,GO:0016639,GO:0019676,GO:0019740,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045181,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.4.1.13,1.4.1.14 ko:K00265 ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 - R00093,R00114,R00248 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - iBWG_1329.BWG_2914,iECDH10B_1368.ECDH10B_3387,iECDH1ME8569_1439.EcDH1_0495,iEcDH1_1363.EcDH1_0495,iPC815.YPO3557 GATase_2,GXGXG,Glu_syn_central,Glu_synthase k59_1106920_1 1380600.AUYN01000009_gene1584 1.73e-162 490.0 COG0046@1|root,COG0047@1|root,COG0046@2|Bacteria,COG0047@2|Bacteria,4NETY@976|Bacteroidetes,1HYI9@117743|Flavobacteriia 976|Bacteroidetes F Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate purL - 6.3.5.3 ko:K01952 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04463 RC00010,RC01160 ko00000,ko00001,ko00002,ko01000 - - - AIRS_C,GATase_5 k59_1782442_1 1163407.UU7_06828 1.74e-10 60.5 2E3S2@1|root,32YPN@2|Bacteria,1NKGG@1224|Proteobacteria,1T0RX@1236|Gammaproteobacteria,1X7SW@135614|Xanthomonadales 135614|Xanthomonadales - - - - - - - - - - - - - - - k59_1782442_2 1219049.SP5_016_00370 1.05e-27 101.0 COG1476@1|root,COG1476@2|Bacteria,1N6SS@1224|Proteobacteria,2UFFG@28211|Alphaproteobacteria,2K6RT@204457|Sphingomonadales 204457|Sphingomonadales K Transcriptional regulator - - - ko:K07729 - - - - ko00000,ko03000 - - - HTH_3 k59_1782442_3 1122137.AQXF01000001_gene3219 1.73e-25 104.0 COG1384@1|root,COG1384@2|Bacteria,1MV32@1224|Proteobacteria,2TQYH@28211|Alphaproteobacteria 28211|Alphaproteobacteria J Belongs to the class-I aminoacyl-tRNA synthetase family lysS - 6.1.1.6 ko:K04566 ko00970,map00970 M00360 R03658 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_1f k59_1445558_1 1395571.TMS3_0107675 4.52e-60 194.0 COG1028@1|root,COG1028@2|Bacteria,1MW50@1224|Proteobacteria,1RRIH@1236|Gammaproteobacteria 1236|Gammaproteobacteria IQ Belongs to the short-chain dehydrogenases reductases (SDR) family - - 1.3.1.25 ko:K05783 ko00362,ko00364,ko00622,ko01100,ko01120,ko01220,map00362,map00364,map00622,map01100,map01120,map01220 M00551 R00813,R05292,R05293,R05309,R05314,R08111,R08112,R08113 RC00271,RC01326,RC01327 br01602,ko00000,ko00001,ko00002,ko01000 - - - adh_short k59_886351_1 1207063.P24_18531 2.36e-40 142.0 COG0559@1|root,COG0559@2|Bacteria,1MU25@1224|Proteobacteria,2TSDS@28211|Alphaproteobacteria,2JQSZ@204441|Rhodospirillales 204441|Rhodospirillales E Belongs to the binding-protein-dependent transport system permease family livH - - ko:K01997 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - BPD_transp_2 k59_1054474_1 1195246.AGRI_07530 1.44e-18 89.4 COG0354@1|root,COG0354@2|Bacteria,1N852@1224|Proteobacteria,1RPWB@1236|Gammaproteobacteria,466QJ@72275|Alteromonadaceae 1236|Gammaproteobacteria S aminomethyltransferase related to GcvT ygfZ GO:0003674,GO:0005488,GO:0005542,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006790,GO:0008144,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0016226,GO:0019842,GO:0022607,GO:0031163,GO:0031406,GO:0033218,GO:0036094,GO:0043167,GO:0043168,GO:0043177,GO:0044085,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0051186,GO:0071840,GO:0072341,GO:0097159,GO:1901363 - ko:K06980 - - - - ko00000,ko03016 - - - GCV_T,GCV_T_C k59_377843_1 1282876.BAOK01000001_gene3536 3.66e-38 144.0 COG2133@1|root,COG2133@2|Bacteria,1MV2E@1224|Proteobacteria,2TR47@28211|Alphaproteobacteria,4BPMV@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria G Glucose / Sorbosone dehydrogenase yliI - 1.1.5.2 ko:K00117,ko:K21430 ko00030,ko01100,ko01110,ko01130,map00030,map01100,map01110,map01130 - R06620 RC00066 ko00000,ko00001,ko01000 - - - Cytochrome_CBB3,GSDH k59_385031_1 702113.PP1Y_AT49 1.01e-192 546.0 COG0069@1|root,COG0069@2|Bacteria,1MU7B@1224|Proteobacteria,2TREH@28211|Alphaproteobacteria,2K14G@204457|Sphingomonadales 204457|Sphingomonadales E Belongs to the glutamate synthase family - - - - - - - - - - - - Glu_synthase k59_1452825_1 745014.OMB55_00009350 2.18e-118 348.0 COG3825@1|root,COG3825@2|Bacteria,1MUAJ@1224|Proteobacteria,1RMRY@1236|Gammaproteobacteria 1236|Gammaproteobacteria S protein conserved in bacteria IV02_28405 - - ko:K09989 - - - - ko00000 - - - VWA_CoxE k59_1452828_2 1229909.NSED_09880 5.24e-70 216.0 arCOG08818@1|root,arCOG08818@2157|Archaea,41SVV@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_610033_1 232346.JHQL01000003_gene292 5.31e-44 154.0 COG1290@1|root,COG1290@2|Bacteria,1MV97@1224|Proteobacteria,1RNCP@1236|Gammaproteobacteria,1XHEG@135619|Oceanospirillales 135619|Oceanospirillales C Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis petB - - ko:K00412 ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016 M00151,M00152 - - ko00000,ko00001,ko00002,ko03029 - - - Cytochrom_B_C,Cytochrome_B k59_610033_2 236097.ADG881_1545 2.4e-40 140.0 COG0723@1|root,COG0723@2|Bacteria,1RAA2@1224|Proteobacteria,1RP9H@1236|Gammaproteobacteria,1XJ8J@135619|Oceanospirillales 135619|Oceanospirillales C Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis petA - 1.10.2.2 ko:K00411 ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016 M00151,M00152 - - ko00000,ko00001,ko00002,ko01000 - - - Rieske,UCR_Fe-S_N k59_662436_1 1144305.PMI02_02299 1.08e-58 188.0 COG1028@1|root,COG1028@2|Bacteria,1REPG@1224|Proteobacteria,2UBJV@28211|Alphaproteobacteria 28211|Alphaproteobacteria IQ Enoyl-(Acyl carrier protein) reductase - - 1.1.1.100 ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 k59_155362_1 436308.Nmar_0780 1.04e-185 537.0 COG0046@1|root,arCOG00641@2157|Archaea,41S6S@651137|Thaumarchaeota 651137|Thaumarchaeota F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL purL - 6.3.5.3 ko:K01952 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04463 RC00010,RC01160 ko00000,ko00001,ko00002,ko01000 - - - AIRS,AIRS_C k59_1789583_1 1229909.NSED_02970 6.36e-82 254.0 COG0412@1|root,arCOG10350@1|root,arCOG01659@2157|Archaea,arCOG10350@2157|Archaea,41T1E@651137|Thaumarchaeota 651137|Thaumarchaeota Q Chlorophyllase - - 3.1.1.45 ko:K01061 ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130 - R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222 RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686 ko00000,ko00001,ko01000 - - - DLH k59_385041_1 1341181.FLJC2902T_13220 3.53e-44 150.0 2DCHV@1|root,2ZE7Q@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_1228923_1 1229909.NSED_02710 2.44e-220 610.0 COG1085@1|root,arCOG00422@2157|Archaea,41S6T@651137|Thaumarchaeota 651137|Thaumarchaeota C Galactose-1-phosphate uridyl transferase, N-terminal domain - - 2.7.7.12 ko:K00965 ko00052,ko00520,ko01100,ko04917,map00052,map00520,map01100,map04917 M00362,M00554,M00632 R00955 RC00002 ko00000,ko00001,ko00002,ko01000 - - - GalP_UDP_transf k59_663402_1 525904.Tter_1279 4.82e-11 63.5 COG0330@1|root,COG0330@2|Bacteria,2NNUC@2323|unclassified Bacteria 2|Bacteria O prohibitin homologues hflC - - - - - - - - - - - Band_7 k59_663402_2 596152.DesU5LDRAFT_1065 1.07e-34 138.0 COG0330@1|root,COG0330@2|Bacteria,1MUM2@1224|Proteobacteria,42NUT@68525|delta/epsilon subdivisions,2WKQX@28221|Deltaproteobacteria,2M80N@213115|Desulfovibrionales 28221|Deltaproteobacteria O HflC and HflK could encode or regulate a protease hflK - - ko:K04088 - M00742 - - ko00000,ko00002,ko01000 - - - Band_7 k59_492723_1 1122137.AQXF01000003_gene2343 2.47e-284 785.0 COG0111@1|root,COG0111@2|Bacteria,1MU5Z@1224|Proteobacteria,2TR0F@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family serA - 1.1.1.399,1.1.1.95 ko:K00058 ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230 M00020 R01513 RC00031 ko00000,ko00001,ko00002,ko01000,ko04147 - - - 2-Hacid_dh,2-Hacid_dh_C,ACT k59_1790610_1 153948.NAL212_1114 1.04e-26 106.0 COG4105@1|root,COG4105@2|Bacteria,1MVS5@1224|Proteobacteria,2VH6I@28216|Betaproteobacteria,371W6@32003|Nitrosomonadales 28216|Betaproteobacteria M Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane bamD - - ko:K05807 - - - - ko00000,ko02000 1.B.33.1 - - YfiO k59_1790611_1 1205680.CAKO01000023_gene4518 1.71e-81 256.0 COG5361@1|root,COG5361@2|Bacteria,1MWTW@1224|Proteobacteria,2TUR1@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Protein of unknown function (DUF1254) - - - - - - - - - - - - DUF1214,DUF1254 k59_271489_1 1203567.HMPREF1286_00399 2.59e-26 107.0 COG0652@1|root,COG0652@2|Bacteria,2IFUE@201174|Actinobacteria,22K8X@1653|Corynebacteriaceae 201174|Actinobacteria O PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides ppiA GO:0000413,GO:0003674,GO:0003755,GO:0003824,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010035,GO:0010038,GO:0010039,GO:0016020,GO:0016853,GO:0016859,GO:0018193,GO:0018208,GO:0019538,GO:0030312,GO:0036211,GO:0042221,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0071704,GO:0071944,GO:0140096,GO:1901564 5.2.1.8 ko:K03767,ko:K03768 ko01503,ko04217,map01503,map04217 - - - ko00000,ko00001,ko01000,ko03110,ko04147 - - - Pro_isomerase k59_663407_1 314287.GB2207_08976 3.34e-77 240.0 COG1932@1|root,COG1932@2|Bacteria,1MUB5@1224|Proteobacteria,1RNB1@1236|Gammaproteobacteria,1J4UW@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria EH Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine - - 2.6.1.52 ko:K00831 ko00260,ko00680,ko00750,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map00750,map01100,map01120,map01130,map01200,map01230 M00020,M00124 R04173,R05085 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_5 k59_663407_2 1415778.JQMM01000001_gene608 7.26e-71 221.0 COG1651@1|root,COG1651@2|Bacteria,1RGWH@1224|Proteobacteria,1S5WA@1236|Gammaproteobacteria,1J6BV@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O DSBA-like thioredoxin domain dsbA GO:0005575,GO:0005623,GO:0042597,GO:0044464 - ko:K03673 ko01503,map01503 M00728 - - ko00000,ko00001,ko00002,ko03110 - - - DSBA,Thioredoxin_4 k59_271490_1 314285.KT71_01650 9.03e-53 178.0 COG2308@1|root,COG2308@2|Bacteria,1MUAD@1224|Proteobacteria,1RNAF@1236|Gammaproteobacteria,1J94R@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Circularly permuted ATP-grasp type 2 - - - - - - - - - - - - CP_ATPgrasp_2 k59_271490_2 1415778.JQMM01000001_gene135 8.51e-26 103.0 COG2307@1|root,COG2307@2|Bacteria,1MVZK@1224|Proteobacteria,1RN2Y@1236|Gammaproteobacteria,1J8TX@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S A predicted alpha-helical domain with a conserved ER motif. - - - - - - - - - - - - Alpha-E k59_833927_1 861299.J421_3108 4.88e-14 72.4 2F044@1|root,33T7T@2|Bacteria,1ZTDC@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - k59_1001189_1 1538644.KO02_18760 9.62e-12 66.6 COG2755@1|root,COG2755@2|Bacteria,4NMUB@976|Bacteroidetes,1IQT1@117747|Sphingobacteriia 976|Bacteroidetes E PFAM Lipase, GDSL - - - - - - - - - - - - Lipase_GDSL_2 k59_1001189_2 1117315.AHCA01000001_gene1995 8.31e-14 71.2 COG0726@1|root,COG0726@2|Bacteria,1RBMV@1224|Proteobacteria,1S27I@1236|Gammaproteobacteria 1236|Gammaproteobacteria G deacetylase - - - - - - - - - - - - Polysacc_deac_1 k59_1284226_1 270374.MELB17_14041 4.67e-98 294.0 COG0082@1|root,COG0082@2|Bacteria,1MU98@1224|Proteobacteria,1RMQS@1236|Gammaproteobacteria,46517@72275|Alteromonadaceae 1236|Gammaproteobacteria E Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system aroC GO:0000166,GO:0003674,GO:0003824,GO:0004107,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0010181,GO:0016053,GO:0016829,GO:0016835,GO:0016838,GO:0019438,GO:0019752,GO:0032553,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050662,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 4.2.3.5 ko:K01736 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R01714 RC00586 ko00000,ko00001,ko00002,ko01000 - - iE2348C_1286.E2348C_2469,iEC55989_1330.EC55989_2573,iECO103_1326.ECO103_2794,iECO111_1330.ECO111_3077,iECO26_1355.ECO26_3317,iECSE_1348.ECSE_2638,iECW_1372.ECW_m2518,iEKO11_1354.EKO11_1436,iSSON_1240.SSON_2387,iUMNK88_1353.UMNK88_2882,iWFL_1372.ECW_m2518 Chorismate_synt k59_1174029_1 36809.MAB_1527 3.56e-06 50.1 COG2072@1|root,COG2072@2|Bacteria,2GJEA@201174|Actinobacteria,23361@1762|Mycobacteriaceae 201174|Actinobacteria P flavoprotein involved in K transport - - - - - - - - - - - - FMO-like,Pyr_redox_3 k59_894644_1 797302.Halru_2968 6.4e-50 180.0 COG0474@1|root,arCOG01578@2157|Archaea,2XT4B@28890|Euryarchaeota,23SFC@183963|Halobacteria 183963|Halobacteria P Cation transporting ATPase, C-terminus - - - - - - - - - - - - Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase k59_1573015_1 377629.TERTU_1857 0.000536 48.1 COG0810@1|root,COG3291@1|root,COG0810@2|Bacteria,COG3291@2|Bacteria,1R5MU@1224|Proteobacteria,1T46G@1236|Gammaproteobacteria,2PPSQ@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria M Repeats in polycystic kidney disease 1 (PKD1) and other proteins - - - - - - - - - - - - REJ k59_1115218_1 589865.DaAHT2_0484 1.7e-49 175.0 COG3666@1|root,COG3666@2|Bacteria,1N3QR@1224|Proteobacteria,42N7X@68525|delta/epsilon subdivisions,2WMM9@28221|Deltaproteobacteria,2MMU3@213118|Desulfobacterales 28221|Deltaproteobacteria L Transposase DDE domain - - - - - - - - - - - - DDE_Tnp_1,DDE_Tnp_1_6,DUF772 k59_611231_1 339860.Msp_0826 5.74e-25 109.0 COG2217@1|root,arCOG01576@2157|Archaea,2Y32M@28890|Euryarchaeota,23PF6@183925|Methanobacteria 183925|Methanobacteria P haloacid dehalogenase-like hydrolase - - - - - - - - - - - - E1-E2_ATPase,Hydrolase k59_1515599_1 1122137.AQXF01000006_gene765 1.94e-115 340.0 COG0341@1|root,COG0341@2|Bacteria,1MU74@1224|Proteobacteria,2TSFW@28211|Alphaproteobacteria 28211|Alphaproteobacteria U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA secF - - ko:K03072,ko:K03074 ko03060,ko03070,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 2.A.6.4,3.A.5.2,3.A.5.7 - - SecD_SecF,Sec_GG k59_45941_1 1347342.BN863_18820 4.49e-45 155.0 2963X@1|root,2ZTE9@2|Bacteria,4NNV8@976|Bacteroidetes,1I2DQ@117743|Flavobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_945369_1 13690.CP98_00967 2.95e-17 86.7 COG4773@1|root,COG4773@2|Bacteria,1MW5E@1224|Proteobacteria,2TSY4@28211|Alphaproteobacteria,2K1PN@204457|Sphingomonadales 204457|Sphingomonadales P TonB-dependent siderophore receptor - - - ko:K16088 - - - - ko00000,ko02000 1.B.14.1.10,1.B.14.1.3,1.B.14.1.8 - - Plug,TonB_dep_Rec k59_1453983_1 1121935.AQXX01000137_gene3947 2.68e-21 97.8 2EXSU@1|root,33R23@2|Bacteria,1NS77@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_1174043_1 1173025.GEI7407_2638 4.34e-38 134.0 COG0066@1|root,COG0066@2|Bacteria,1G2Y2@1117|Cyanobacteria,1H95M@1150|Oscillatoriales 1117|Cyanobacteria E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate leuD - 4.2.1.33,4.2.1.35 ko:K01704 ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230 M00432,M00535 R03896,R03898,R03968,R04001,R10170 RC00976,RC00977,RC01041,RC01046,RC03072 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase_C k59_1174043_2 318424.EU78_16060 3.11e-34 129.0 COG1062@1|root,COG1062@2|Bacteria,2GM8C@201174|Actinobacteria,232XA@1762|Mycobacteriaceae 201174|Actinobacteria C alcohol dehydrogenase - - 1.1.1.1,1.1.1.284 ko:K00121 ko00010,ko00071,ko00350,ko00625,ko00626,ko00680,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,ko05204,map00010,map00071,map00350,map00625,map00626,map00680,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01200,map01220,map05204 - R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R06983,R07105,R08281,R08306,R08310 RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01715,RC01734,RC02273 ko00000,ko00001,ko01000 - - - ADH_N,ADH_zinc_N k59_45952_1 637905.SVI_3258 1.92e-30 112.0 2E3XG@1|root,32YUI@2|Bacteria,1N8RF@1224|Proteobacteria,1SCJ3@1236|Gammaproteobacteria,2QCG5@267890|Shewanellaceae 1236|Gammaproteobacteria S Binds the second messenger bis-(3'-5') cyclic dimeric guanosine monophosphate (c-di-GMP). Can bind two c-di-GMP molecules per monomer. May play a role in bacterial second- messenger regulated processes. Binding to c-di-GMP induces a conformational change of the C- and N-termini resulting in the exposure of a highly negative surface on one side of the protein to a - - - - - - - - - - - - PilZ k59_492764_1 1122929.KB908219_gene1814 3.07e-13 73.9 COG2063@1|root,COG2063@2|Bacteria,1RDEY@1224|Proteobacteria,2TRHN@28211|Alphaproteobacteria 28211|Alphaproteobacteria N Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation flgH - - ko:K02393 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - FlgH k59_833968_1 688246.Premu_2194 4.24e-07 56.6 COG0463@1|root,COG0463@2|Bacteria,4NQ67@976|Bacteroidetes,2FT7S@200643|Bacteroidia 976|Bacteroidetes M overlaps another CDS with the same product name - - - - - - - - - - - - Glycos_transf_2 k59_1115246_1 883081.HMPREF9698_01486 7.46e-08 54.3 COG0822@1|root,COG0822@2|Bacteria,1V3H9@1239|Firmicutes,4HIJ0@91061|Bacilli,27GF7@186828|Carnobacteriaceae 91061|Bacilli C NifU-like N terminal domain nifU GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006807,GO:0006873,GO:0006875,GO:0006879,GO:0008150,GO:0008152,GO:0008198,GO:0009987,GO:0010467,GO:0016740,GO:0016782,GO:0019538,GO:0019725,GO:0030003,GO:0036455,GO:0042592,GO:0043167,GO:0043169,GO:0043170,GO:0044238,GO:0044424,GO:0044464,GO:0046872,GO:0046914,GO:0046916,GO:0048037,GO:0048878,GO:0050801,GO:0051536,GO:0051537,GO:0051539,GO:0051540,GO:0051604,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0065007,GO:0065008,GO:0071704,GO:0097428,GO:0098771,GO:1901564 - ko:K04488 - - - - ko00000 - - - NifU_N k59_1115246_2 1121013.P873_03985 8.43e-30 111.0 COG2151@1|root,COG2151@2|Bacteria,1MZ9Y@1224|Proteobacteria,1S36X@1236|Gammaproteobacteria,1X3XG@135614|Xanthomonadales 135614|Xanthomonadales S FeS assembly SUF system protein SufT - - - - - - - - - - - - FeS_assembly_P k59_1115247_1 1110697.NCAST_33_00140 1.01e-07 60.5 COG0515@1|root,COG0515@2|Bacteria,2GNT2@201174|Actinobacteria,4G8M2@85025|Nocardiaceae 201174|Actinobacteria KLT Protein tyrosine kinase - - 2.7.11.1 ko:K08884,ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Lpp-LpqN,Pkinase k59_1738247_1 331869.BAL199_05269 8.12e-19 84.7 2AFUA@1|root,315WQ@2|Bacteria,1NHGB@1224|Proteobacteria,2TQWW@28211|Alphaproteobacteria,4BQMD@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria S Putative transmembrane protein (Alph_Pro_TM) MA20_19830 - - - - - - - - - - - Alph_Pro_TM k59_271522_2 1096930.L284_06225 2.83e-65 212.0 COG0399@1|root,COG0399@2|Bacteria,1MUPN@1224|Proteobacteria,2TQVS@28211|Alphaproteobacteria,2K340@204457|Sphingomonadales 204457|Sphingomonadales E Belongs to the DegT DnrJ EryC1 family - - - - - - - - - - - - DegT_DnrJ_EryC1 k59_663471_1 1537994.JQFW01000030_gene3698 2.03e-54 190.0 COG1199@1|root,COG1199@2|Bacteria,1MVCU@1224|Proteobacteria,1RMNX@1236|Gammaproteobacteria,465XA@72275|Alteromonadaceae 1236|Gammaproteobacteria KL COG1199 Rad3-related DNA helicases yoaA GO:0003674,GO:0003824,GO:0004386,GO:0006139,GO:0006259,GO:0006281,GO:0006301,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008026,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0070035,GO:0071704,GO:0090304,GO:1901360 3.6.4.12 ko:K03722 - - - - ko00000,ko01000,ko03400 - - - DEAD,DEAD_2,Helicase_C_2,ResIII k59_1454001_1 316407.85676025 1.29e-86 264.0 COG1485@1|root,COG1485@2|Bacteria,1MUUW@1224|Proteobacteria,1RMTJ@1236|Gammaproteobacteria,3XNFW@561|Escherichia 1236|Gammaproteobacteria D Reduces the stability of FtsZ polymers in the presence of ATP zapE GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032153,GO:0044424,GO:0044464,GO:0051301 - ko:K06916 - - - - ko00000,ko03036 - - - AFG1_ATPase k59_1230022_1 335284.Pcryo_2080 2.28e-08 57.0 COG4339@1|root,COG4339@2|Bacteria,1MZ9X@1224|Proteobacteria,1S59I@1236|Gammaproteobacteria,3NIJ4@468|Moraxellaceae 1236|Gammaproteobacteria S protein conserved in bacteria - - - - - - - - - - - - - k59_1230022_2 1279017.AQYJ01000029_gene3351 1.12e-58 190.0 COG1131@1|root,COG1131@2|Bacteria,1MUW7@1224|Proteobacteria,1RMC5@1236|Gammaproteobacteria,465BH@72275|Alteromonadaceae 1236|Gammaproteobacteria V COG1131 ABC-type multidrug transport system, ATPase component yadG GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0009314,GO:0009628,GO:0010165,GO:0010212,GO:0016020,GO:0044464,GO:0050896,GO:0071944 - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_1115253_2 1144319.PMI16_02478 1.29e-95 288.0 COG0223@1|root,COG0223@2|Bacteria,1PHQ5@1224|Proteobacteria,2W46P@28216|Betaproteobacteria 28216|Betaproteobacteria J Formyl transferase - - - - - - - - - - - - Formyl_trans_N k59_386162_1 190650.CC_2647 1.28e-85 259.0 COG0625@1|root,COG0625@2|Bacteria,1RA4M@1224|Proteobacteria,2TV0I@28211|Alphaproteobacteria 28211|Alphaproteobacteria O Glutathione S-transferase - - 2.5.1.18 ko:K00799 ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418 - R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905 RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944 ko00000,ko00001,ko01000,ko02000 1.A.12.2.2,1.A.12.3.2 - - GST_C,GST_C_2,GST_N,GST_N_3 k59_386162_2 1238450.VIBNISOn1_450089 3.07e-05 45.8 COG0454@1|root,COG0456@2|Bacteria,1QXDR@1224|Proteobacteria,1T39A@1236|Gammaproteobacteria,1XYQG@135623|Vibrionales 135623|Vibrionales K Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_1 k59_213574_1 935863.AWZR01000006_gene1263 2.06e-23 104.0 COG2203@1|root,COG5001@1|root,COG2203@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1X4ZZ@135614|Xanthomonadales 135614|Xanthomonadales T GGDEF domain - - - - - - - - - - - - EAL,GAF_2,GGDEF k59_1174086_1 1121033.AUCF01000031_gene74 2.79e-15 82.8 COG0642@1|root,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,2U53G@28211|Alphaproteobacteria,2JREC@204441|Rhodospirillales 204441|Rhodospirillales T Histidine kinase - - - - - - - - - - - - HATPase_c,HisKA,PAS_4 k59_271546_1 1096930.L284_10590 1.02e-132 383.0 COG2896@1|root,COG2896@2|Bacteria,1MW3W@1224|Proteobacteria,2TQQP@28211|Alphaproteobacteria,2K041@204457|Sphingomonadales 204457|Sphingomonadales H Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate moaA - 4.1.99.22 ko:K03639 ko00790,ko01100,ko04122,map00790,map01100,map04122 - R09394 RC03420 ko00000,ko00001,ko01000 - - - Fer4_12,Mob_synth_C,Radical_SAM k59_1284290_1 338963.Pcar_1382 3.34e-41 138.0 COG2963@1|root,COG2963@2|Bacteria 2|Bacteria L transposase activity - - - ko:K07483 - - - - ko00000 - - - HTH_28,HTH_Tnp_1 k59_1284290_2 338963.Pcar_1381 6.38e-82 252.0 COG2801@1|root,COG2801@2|Bacteria,1MZ45@1224|Proteobacteria,42MM6@68525|delta/epsilon subdivisions,2WJ53@28221|Deltaproteobacteria 28221|Deltaproteobacteria L PFAM Integrase catalytic region - - - - - - - - - - - - HTH_29,rve k59_1174089_1 1229909.NSED_00210 2.3e-88 271.0 COG0252@1|root,arCOG01924@2157|Archaea,41SD7@651137|Thaumarchaeota 651137|Thaumarchaeota J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate gatD - 6.3.5.7 ko:K09482 ko00970,ko01100,map00970,map01100 - R03905 RC00010 ko00000,ko00001,ko01000 - - - Asparaginase k59_1738271_1 1219045.BV98_003384 5.16e-79 260.0 COG1009@1|root,COG2111@1|root,COG1009@2|Bacteria,COG2111@2|Bacteria,1MW2M@1224|Proteobacteria,2TRIR@28211|Alphaproteobacteria,2K1G5@204457|Sphingomonadales 204457|Sphingomonadales CP Domain related to MnhB subunit of Na+/H+ antiporter phaAB - - ko:K05559 - - - - ko00000,ko02000 2.A.63.1 - - DUF4040,MnhB,Proton_antipo_M,Proton_antipo_N k59_1284291_1 1101191.KI912577_gene3022 1.08e-22 93.2 COG3415@1|root,COG3415@2|Bacteria,1N5FB@1224|Proteobacteria,2VBH6@28211|Alphaproteobacteria,1JV3Z@119045|Methylobacteriaceae 28211|Alphaproteobacteria L Transposase - - - - - - - - - - - - HTH_Tnp_IS630 k59_1284291_2 1550073.JROH01000010_gene1239 3.74e-26 102.0 2DG7F@1|root,2ZUTR@2|Bacteria,1PAGK@1224|Proteobacteria,2UWC2@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_1001219_1 1051646.VITU9109_07309 3.79e-17 84.0 2AI3F@1|root,318H8@2|Bacteria,1Q0D7@1224|Proteobacteria,1TIA7@1236|Gammaproteobacteria,1XYQX@135623|Vibrionales 135623|Vibrionales - - - - - - - - - - - - - - - k59_1738273_1 1122226.AUHX01000004_gene1814 4.3e-26 105.0 29FPJ@1|root,302M6@2|Bacteria,4NNQ8@976|Bacteroidetes,1I2J8@117743|Flavobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_1403245_1 377629.TERTU_2113 1.42e-59 199.0 COG3067@1|root,COG3067@2|Bacteria,1MV0F@1224|Proteobacteria,1RPE3@1236|Gammaproteobacteria,2PPPX@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria P Bacterial Na+/H+ antiporter B (NhaB) nhaB GO:0003674,GO:0005215,GO:0005451,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006814,GO:0006873,GO:0006885,GO:0008150,GO:0008324,GO:0009987,GO:0010035,GO:0010038,GO:0010226,GO:0015075,GO:0015077,GO:0015078,GO:0015081,GO:0015291,GO:0015297,GO:0015298,GO:0015299,GO:0015318,GO:0015385,GO:0015491,GO:0015672,GO:0016020,GO:0019725,GO:0022804,GO:0022857,GO:0022890,GO:0030001,GO:0030003,GO:0030004,GO:0030641,GO:0034220,GO:0035725,GO:0042221,GO:0042592,GO:0044464,GO:0045851,GO:0046873,GO:0048878,GO:0050801,GO:0050896,GO:0051179,GO:0051234,GO:0051452,GO:0051453,GO:0055067,GO:0055080,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:0098771,GO:0099516,GO:1902600 - ko:K03314 - - - - ko00000,ko02000 2.A.34.1 - iECP_1309.ECP_1229,iLF82_1304.LF82_1485,iNRG857_1313.NRG857_06055,iUTI89_1310.UTI89_C1372 NhaB k59_271558_1 485915.Dret_1561 6.38e-23 97.8 COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,42WT2@68525|delta/epsilon subdivisions,2WR9X@28221|Deltaproteobacteria,2MAU1@213115|Desulfovibrionales 28221|Deltaproteobacteria L PFAM transposase IS116 IS110 IS902 family protein - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_444084_2 589865.DaAHT2_0310 1.08e-39 139.0 COG3271@1|root,COG3271@2|Bacteria,1RAD5@1224|Proteobacteria,42QWA@68525|delta/epsilon subdivisions,2WMVM@28221|Deltaproteobacteria,2MNBG@213118|Desulfobacterales 28221|Deltaproteobacteria S Peptidase_C39 like family - - - - - - - - - - - - Peptidase_C39,Peptidase_C39_2 k59_1347467_1 1227276.HMPREF9148_00565 2.88e-27 104.0 COG0251@1|root,COG0251@2|Bacteria,4NQ8M@976|Bacteroidetes,2FT8J@200643|Bacteroidia 976|Bacteroidetes J endoribonuclease L-PSP ridA - 3.5.99.10 ko:K09022 - - R11098,R11099 RC03275,RC03354 ko00000,ko01000 - - - Ribonuc_L-PSP k59_952260_1 1358423.N180_06030 7.93e-44 148.0 COG2818@1|root,COG2818@2|Bacteria,4NGRC@976|Bacteroidetes,1IQSX@117747|Sphingobacteriia 976|Bacteroidetes L DNA-3-methyladenine glycosylase tag - 3.2.2.20 ko:K01246 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - Adenine_glyco k59_952260_2 675814.VIC_003274 2.15e-37 136.0 COG0579@1|root,COG0579@2|Bacteria,1N0QB@1224|Proteobacteria,1RN24@1236|Gammaproteobacteria,1XTAP@135623|Vibrionales 135623|Vibrionales S Hydroxyglutarate oxidase - - - ko:K15736 - - - - ko00000,ko01000 - - - DAO k59_163275_1 225937.HP15_2751 1.29e-34 135.0 COG4775@1|root,COG4775@2|Bacteria,1PT0R@1224|Proteobacteria,1RPWY@1236|Gammaproteobacteria,4660F@72275|Alteromonadaceae 1236|Gammaproteobacteria M COG4775 Outer membrane protein protective antigen OMA87 - - - - - - - - - - - - Bac_surface_Ag,ShlB k59_1347471_1 999541.bgla_2g28820 3.45e-21 93.6 COG3634@1|root,COG3634@2|Bacteria,1MUKD@1224|Proteobacteria,2VJ01@28216|Betaproteobacteria,1K1YC@119060|Burkholderiaceae 28216|Betaproteobacteria C alkyl hydroperoxide reductase ahpF - - ko:K03387 - - - - ko00000,ko01000 - - - Pyr_redox_2,Thioredoxin_3 k59_1347471_2 570268.ANBB01000044_gene1749 0.000904 42.0 COG0685@1|root,COG0685@2|Bacteria,2H891@201174|Actinobacteria 201174|Actinobacteria E Methylene-tetrahydrofolate reductase C terminal - - - - - - - - - - - - MTHFR_C k59_1687958_1 1536774.H70357_09260 1.75e-21 103.0 COG2199@1|root,COG3706@2|Bacteria,1TS77@1239|Firmicutes,4IQD7@91061|Bacilli 91061|Bacilli T 5TMR of 5TMR-LYT - - - - - - - - - - - - 5TM-5TMR_LYT,GGDEF,PAS_9 k59_1180796_1 685782.O99_01074 1.43e-07 58.2 COG0642@1|root,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,2TRHH@28211|Alphaproteobacteria,48TNE@772|Bartonellaceae 28211|Alphaproteobacteria T Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) pleC - 2.7.13.3 ko:K07716 ko02020,ko04112,map02020,map04112 M00511 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA,PAS,PAS_3,PAS_7 k59_1522391_1 1248917.ANFX01000019_gene2355 8.01e-44 162.0 COG4774@1|root,COG4774@2|Bacteria,1NMCN@1224|Proteobacteria,2TVPT@28211|Alphaproteobacteria,2K2IS@204457|Sphingomonadales 204457|Sphingomonadales P TonB-dependent receptor - - - - - - - - - - - - Plug,TonB_dep_Rec k59_108857_1 1134474.O59_003413 1.53e-102 329.0 COG0642@1|root,COG0784@1|root,COG1457@1|root,COG0784@2|Bacteria,COG1457@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,1RRGT@1236|Gammaproteobacteria,1FG1G@10|Cellvibrio 1236|Gammaproteobacteria T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA,Response_reg k59_555216_1 1123261.AXDW01000009_gene74 1.27e-21 94.4 COG1999@1|root,COG1999@2|Bacteria,1N6R6@1224|Proteobacteria,1SC88@1236|Gammaproteobacteria,1X800@135614|Xanthomonadales 135614|Xanthomonadales S signal sequence binding - - - - - - - - - - - - SCO1-SenC k59_555216_2 349521.HCH_00051 1.14e-09 59.3 COG3346@1|root,COG3346@2|Bacteria,1MZUH@1224|Proteobacteria,1S8S0@1236|Gammaproteobacteria,1XM7Q@135619|Oceanospirillales 135619|Oceanospirillales S SURF1-like protein - - - - - - - - - - - - SURF1 k59_108860_1 425104.Ssed_3260 3.79e-12 70.5 COG2207@1|root,COG2207@2|Bacteria,1RB3B@1224|Proteobacteria,1S2BJ@1236|Gammaproteobacteria,2QB7A@267890|Shewanellaceae 1236|Gammaproteobacteria K PFAM helix-turn-helix- domain containing protein, AraC type - - - - - - - - - - - - AraC_binding,HTH_18 k59_1291418_1 522772.Dacet_2568 1.31e-38 138.0 COG2801@1|root,COG2963@1|root,COG2801@2|Bacteria,COG2963@2|Bacteria 2|Bacteria L transposase activity - - - ko:K07483,ko:K07497 - - - - ko00000 - - - HTH_21,HTH_Tnp_1,rve,rve_3 k59_336147_1 999541.bgla_1g18060 2.73e-77 254.0 COG0567@1|root,COG0567@2|Bacteria,1MVBF@1224|Proteobacteria,2VJ0G@28216|Betaproteobacteria,1K532@119060|Burkholderiaceae 28216|Betaproteobacteria C Dehydrogenase E1 component sucA - 1.2.4.2 ko:K00164 ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00032 R00621,R01933,R01940,R03316,R08549 RC00004,RC00027,RC00627,RC02743,RC02833,RC02883 br01601,ko00000,ko00001,ko00002,ko01000 - - - 2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr k59_52854_1 395495.Lcho_3224 6.14e-09 58.9 COG0475@1|root,COG0475@2|Bacteria,1R9PF@1224|Proteobacteria,2VKV2@28216|Betaproteobacteria,1KKRF@119065|unclassified Burkholderiales 28216|Betaproteobacteria P Sodium hydrogen exchanger - - - - - - - - - - - - Na_H_Exchanger k59_52854_2 375286.mma_2607 1.02e-20 91.3 COG2170@1|root,COG2170@2|Bacteria,1MX4N@1224|Proteobacteria,2VK27@28216|Betaproteobacteria,47394@75682|Oxalobacteraceae 28216|Betaproteobacteria H ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity ybdK - - ko:K06048 - - - - ko00000,ko01000 - - - GCS2 k59_1347514_1 1088721.NSU_2863 4.8e-61 194.0 COG0356@1|root,COG0356@2|Bacteria,1MV87@1224|Proteobacteria,2TRNV@28211|Alphaproteobacteria,2K17B@204457|Sphingomonadales 204457|Sphingomonadales C it plays a direct role in the translocation of protons across the membrane atpB - - ko:K02108 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko03110 3.A.2.1 - - ATP-synt_A k59_1347514_2 1144305.PMI02_00547 6.64e-41 136.0 COG5336@1|root,COG5336@2|Bacteria,1N2ME@1224|Proteobacteria,2UCBR@28211|Alphaproteobacteria,2K62W@204457|Sphingomonadales 204457|Sphingomonadales S function for this protein is to guide the assembly of the membrane sector of the ATPase enzyme complex atpI - - ko:K02116 - - - - ko00000,ko00194 3.A.2.1 - - ATPase_gene1 k59_1069100_1 1345592.CBOM010000014_gene1110 0.000174 48.1 COG0363@1|root,COG0363@2|Bacteria,1R5K6@1224|Proteobacteria,42UV6@68525|delta/epsilon subdivisions,2YPDE@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria G 6-phosphogluconolactonase pgl - 3.1.1.31 ko:K01057 ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200 M00004,M00006,M00008 R02035 RC00537 ko00000,ko00001,ko00002,ko01000 - - - Glucosamine_iso k59_1069100_2 1122137.AQXF01000007_gene3588 5.73e-143 421.0 COG0129@1|root,COG0129@2|Bacteria,1MU3T@1224|Proteobacteria,2TQNS@28211|Alphaproteobacteria 28211|Alphaproteobacteria EG Belongs to the IlvD Edd family edd - 4.2.1.12 ko:K01690 ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200 M00008 R02036 RC00543 ko00000,ko00001,ko00002,ko01000 - - - ILVD_EDD k59_52866_1 395494.Galf_2724 5.58e-148 442.0 COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,2VH8J@28216|Betaproteobacteria,44VKX@713636|Nitrosomonadales 28216|Betaproteobacteria P ATPase, P-type (transporting), HAD superfamily, subfamily IC copF - 3.6.3.54 ko:K17686 ko01524,ko04016,map01524,map04016 - R00086 RC00002 ko00000,ko00001,ko01000 3.A.3.5 - - E1-E2_ATPase,Hydrolase,YHS k59_952313_1 1007104.SUS17_437 1.12e-32 127.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2TQT0@28211|Alphaproteobacteria,2K02H@204457|Sphingomonadales 204457|Sphingomonadales V Efflux pump membrane transporter - - - ko:K18138 ko01501,ko01503,map01501,map01503 M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000 2.A.6.2 - - ACR_tran k59_555248_2 1122180.Lokhon_02175 2.3e-11 70.9 COG0457@1|root,COG1216@1|root,COG0457@2|Bacteria,COG1216@2|Bacteria,1R1ZZ@1224|Proteobacteria,2TZGV@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Polysaccharide pyruvyl transferase - - - - - - - - - - - - PS_pyruv_trans k59_444161_1 582744.Msip34_0601 1.66e-53 176.0 COG1234@1|root,COG1234@2|Bacteria,1QU4B@1224|Proteobacteria,2VH0D@28216|Betaproteobacteria,2KMHV@206350|Nitrosomonadales 206350|Nitrosomonadales S cAMP phosphodiesterases class-II - - - - - - - - - - - - Lactamase_B_2 k59_278517_1 400668.Mmwyl1_2732 7.38e-40 143.0 COG0501@1|root,COG0501@2|Bacteria,1MUNA@1224|Proteobacteria,1RMZ6@1236|Gammaproteobacteria,1XIXM@135619|Oceanospirillales 135619|Oceanospirillales O peptidase - - - - - - - - - - - - Peptidase_M48 k59_1069109_1 247634.GPB2148_3410 2.56e-76 254.0 COG0086@1|root,COG0086@2|Bacteria,1MU3M@1224|Proteobacteria,1RPYH@1236|Gammaproteobacteria,1J4ZQ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoC GO:0000428,GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0030880,GO:0032774,GO:0032991,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234 2.7.7.6 ko:K03046 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5 k59_1632818_1 522306.CAP2UW1_1058 5.15e-120 353.0 COG0596@1|root,COG0596@2|Bacteria,1MVVX@1224|Proteobacteria,2VH81@28216|Betaproteobacteria 28216|Betaproteobacteria S Alpha beta hydrolase phaY2 - - - - - - - - - - - Abhydrolase_1,Abhydrolase_6 k59_555255_1 1037409.BJ6T_39650 4.84e-44 161.0 COG4993@1|root,COG4993@2|Bacteria,1MUQX@1224|Proteobacteria,2TQMV@28211|Alphaproteobacteria,3JSPM@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria G PQQ-like domain - - 1.1.5.2 ko:K00117 ko00030,ko01100,ko01110,ko01130,map00030,map01100,map01110,map01130 - R06620 RC00066 ko00000,ko00001,ko01000 - - - PQQ,PQQ_2 k59_1797363_1 1216007.AOPM01000052_gene2184 5.05e-73 233.0 COG0624@1|root,COG0624@2|Bacteria,1MVUX@1224|Proteobacteria,1RPPD@1236|Gammaproteobacteria,2Q0MZ@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria E Peptidase family M28 - - 3.5.1.6,3.5.1.87,3.5.3.9 ko:K02083,ko:K06016 ko00230,ko00240,ko01100,ko01120,map00230,map00240,map01100,map01120 M00046 R00905,R02423,R04666 RC00064,RC00096 ko00000,ko00001,ko00002,ko01000,ko01002 - - - M20_dimer,Peptidase_M20,Peptidase_M28 k59_444175_2 436308.Nmar_1015 2.1e-15 75.9 arCOG10350@1|root,arCOG10350@2157|Archaea 2157|Archaea C sister chromatid segregation - - - - - - - - - - - - - k59_670376_1 713587.THITH_05405 1.59e-34 121.0 COG2146@1|root,COG2146@2|Bacteria,1N03R@1224|Proteobacteria,1S9CV@1236|Gammaproteobacteria,1X17V@135613|Chromatiales 135613|Chromatiales P Rieske-like [2Fe-2S] domain - - 1.7.1.15 ko:K00363 ko00910,ko01120,map00910,map01120 M00530 R00787 RC00176 ko00000,ko00001,ko00002,ko01000 - - - Rieske_2 k59_670376_2 555778.Hneap_1114 3.16e-34 131.0 COG1251@1|root,COG1251@2|Bacteria,1MW58@1224|Proteobacteria,1RNGY@1236|Gammaproteobacteria,1WWFC@135613|Chromatiales 135613|Chromatiales C Pyridine nucleotide-disulphide oxidoreductase - - 1.18.1.1,1.7.1.15 ko:K00362,ko:K05297 ko00071,ko00910,ko01120,map00071,map00910,map01120 M00530 R00787,R02000 RC00176 ko00000,ko00001,ko00002,ko01000 - - - Fer2_BFD,NIR_SIR,NIR_SIR_ferr,Pyr_redox_2 k59_1580066_1 1229909.NSED_07595 1.06e-102 302.0 COG0005@1|root,arCOG01327@2157|Archaea,41SDR@651137|Thaumarchaeota 651137|Thaumarchaeota F Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates mtnP - 2.4.2.28 ko:K00772 ko00270,ko01100,map00270,map01100 M00034 R01402 RC00063,RC02819 ko00000,ko00001,ko00002,ko01000 - - - PNP_UDP_1 k59_1410250_1 648757.Rvan_0598 9.89e-29 105.0 COG1553@1|root,COG1553@2|Bacteria,1N021@1224|Proteobacteria,2UA3H@28211|Alphaproteobacteria 28211|Alphaproteobacteria P DsrE/DsrF-like family - - - ko:K07235 ko04122,map04122 - - - ko00000,ko00001,ko01000,ko03016 - - - DrsE k59_1410250_2 1049564.TevJSym_aw00170 3.01e-54 172.0 COG2923@1|root,COG2923@2|Bacteria,1N8RV@1224|Proteobacteria,1SD0S@1236|Gammaproteobacteria 1236|Gammaproteobacteria P Belongs to the DsrF TusC family tusC GO:0002097,GO:0002098,GO:0002143,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0032991,GO:0034227,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1902494,GO:1990228,GO:1990234 - ko:K07236 ko04122,map04122 - - - ko00000,ko00001,ko03016 - - - DrsE k59_1580086_1 1229909.NSED_08930 1.76e-109 323.0 arCOG10597@1|root,arCOG10597@2157|Archaea 2157|Archaea O serine-type endopeptidase activity - - - - - - - - - - - - - k59_1688041_1 314285.KT71_19011 1.6e-21 98.6 COG4775@1|root,COG4775@2|Bacteria,1MU0D@1224|Proteobacteria,1RMAP@1236|Gammaproteobacteria,1J4CD@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane bamA GO:0005575,GO:0005623,GO:0008104,GO:0008150,GO:0009279,GO:0009987,GO:0016020,GO:0016043,GO:0019867,GO:0022607,GO:0030312,GO:0030313,GO:0031224,GO:0031230,GO:0031241,GO:0031246,GO:0031975,GO:0032991,GO:0033036,GO:0034613,GO:0043163,GO:0043165,GO:0044085,GO:0044091,GO:0044425,GO:0044462,GO:0044464,GO:0045184,GO:0045229,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0061024,GO:0070727,GO:0071709,GO:0071840,GO:0071944,GO:0072657,GO:0090150,GO:0098552,GO:0098796,GO:1990063 - ko:K07277 - - - - ko00000,ko02000,ko03029 1.B.33 - - Bac_surface_Ag,POTRA k59_1069128_1 1122612.AUBA01000017_gene2750 1.36e-24 103.0 COG2897@1|root,COG2897@2|Bacteria,1MW4B@1224|Proteobacteria,2TR9R@28211|Alphaproteobacteria,2K1GF@204457|Sphingomonadales 204457|Sphingomonadales P Catalyzes the transfer of a sulfur ion to cyanide or to other thiol compounds sseA - 2.8.1.1,2.8.1.2 ko:K01011 ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122 - R01931,R03105,R03106 RC00214 ko00000,ko00001,ko01000 - - - Rhodanese k59_1069131_2 93220.LV28_22925 6.93e-23 95.5 COG0546@1|root,COG0546@2|Bacteria,1RCXJ@1224|Proteobacteria,2VS13@28216|Betaproteobacteria,1JZZC@119060|Burkholderiaceae 28216|Betaproteobacteria G Phosphoglycolate phosphatase gph - 3.1.3.105 ko:K22292 ko00520,map00520 - R11785 RC00017 ko00000,ko00001,ko01000 - - - HAD_2 k59_444200_2 1125973.JNLC01000011_gene276 7.8e-36 131.0 COG1702@1|root,COG1702@2|Bacteria,1MVDV@1224|Proteobacteria,2TRV3@28211|Alphaproteobacteria,3JS5Z@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria T PhoH-like protein phoH - - ko:K06217 - - - - ko00000 - - - PhoH k59_1410257_1 1157637.KB892090_gene6094 4.04e-22 95.9 COG1132@1|root,COG1132@2|Bacteria,2GITR@201174|Actinobacteria 201174|Actinobacteria V ABC transporter - - - ko:K06147 - - - - ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran k59_163364_1 187272.Mlg_2442 3.2e-82 265.0 COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,1RN3H@1236|Gammaproteobacteria,1WWZ3@135613|Chromatiales 135613|Chromatiales KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance - - 2.7.6.5,3.1.7.2 ko:K01139 ko00230,map00230 - R00336,R00429 RC00002,RC00078 ko00000,ko00001,ko01000,ko03009 - - - ACT_4,HD_4,RelA_SpoT,TGS k59_108935_1 1121445.ATUZ01000015_gene1778 3.59e-13 67.8 COG2127@1|root,COG2127@2|Bacteria,1MZU8@1224|Proteobacteria,42TN3@68525|delta/epsilon subdivisions,2WQ23@28221|Deltaproteobacteria,2MCM5@213115|Desulfovibrionales 28221|Deltaproteobacteria S Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation clpS - - ko:K06891 - - - - ko00000 - - - ClpS k59_108935_2 1480694.DC28_11510 5.36e-09 58.2 COG3146@1|root,COG3146@2|Bacteria 2|Bacteria S Peptidogalycan biosysnthesis/recognition MA20_36195 - - ko:K09919 - - - - ko00000 - - - FemAB_like k59_1007844_1 1123261.AXDW01000001_gene1445 1.09e-63 202.0 COG1136@1|root,COG1136@2|Bacteria,1MVSQ@1224|Proteobacteria,1RMWK@1236|Gammaproteobacteria,1X2X9@135614|Xanthomonadales 135614|Xanthomonadales V Part of the ABC transporter complex LolCDE involved in the translocation of lolD - - ko:K09810 ko02010,map02010 M00255 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.125 - - ABC_tran k59_1580118_1 870187.Thini_0481 1.64e-47 168.0 COG1100@1|root,COG1100@2|Bacteria,1QXSV@1224|Proteobacteria,1S5FA@1236|Gammaproteobacteria 1236|Gammaproteobacteria S 50S ribosome-binding GTPase - - - ko:K06883 - - - - ko00000 - - - DUF697,MMR_HSR1 k59_1347598_1 864702.OsccyDRAFT_2457 7.36e-121 355.0 COG0031@1|root,COG0031@2|Bacteria,1G1AB@1117|Cyanobacteria,1H7G5@1150|Oscillatoriales 1117|Cyanobacteria E Belongs to the cysteine synthase cystathionine beta- synthase family cysK - 2.5.1.47 ko:K01738 ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230 M00021 R00897,R03601,R04859 RC00020,RC02814,RC02821 ko00000,ko00001,ko00002,ko01000 - - - PALP k59_1236633_1 247634.GPB2148_797 6.44e-43 148.0 COG0583@1|root,COG0583@2|Bacteria,1RGTE@1224|Proteobacteria,1S543@1236|Gammaproteobacteria,1JA5U@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria K COG0583 Transcriptional regulator - - - ko:K21699 - - - - ko00000,ko03000 - - - HTH_1,LysR_substrate k59_1236633_2 314285.KT71_05802 1.54e-23 99.4 COG0578@1|root,COG0578@2|Bacteria,1MUMY@1224|Proteobacteria,1RMGP@1236|Gammaproteobacteria,1J8WF@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C C-terminal domain of alpha-glycerophosphate oxidase - - 1.1.3.21,1.1.5.3 ko:K00105,ko:K00111 ko00564,ko01110,map00564,map01110 - R00846,R00848 RC00029 ko00000,ko00001,ko01000 - - - DAO,DAO_C k59_1580131_1 118161.KB235922_gene2022 1.86e-69 221.0 COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,1G3YK@1117|Cyanobacteria,3VNCI@52604|Pleurocapsales 1117|Cyanobacteria L DDE superfamily endonuclease - - - - - - - - - - - - DDE_3,HTH_23 k59_1069162_1 1122137.AQXF01000003_gene2085 7.24e-43 159.0 COG4774@1|root,COG4774@2|Bacteria,1R6E9@1224|Proteobacteria,2UR6V@28211|Alphaproteobacteria 28211|Alphaproteobacteria P TonB dependent receptor - - - - - - - - - - - - Plug,TonB_dep_Rec k59_1745039_1 1444711.CCJF01000005_gene356 1.03e-21 88.6 2E4EA@1|root,32Z9I@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_499530_1 1122137.AQXF01000006_gene700 2.8e-05 45.8 COG1086@1|root,COG1086@2|Bacteria,1MWKY@1224|Proteobacteria,2TT4K@28211|Alphaproteobacteria 28211|Alphaproteobacteria GM Polysaccharide biosynthesis protein - - 4.2.1.115 ko:K15894 ko00520,map00520 - R09697 RC02609 ko00000,ko00001,ko01000 - - - Polysacc_synt_2 k59_499530_2 1122137.AQXF01000006_gene701 6.44e-90 288.0 COG1449@1|root,COG1449@2|Bacteria,1R51R@1224|Proteobacteria 1224|Proteobacteria G Belongs to the glycosyl hydrolase 57 family - - - - - - - - - - - - Glyco_hydro_57 k59_1291515_1 2074.JNYD01000005_gene3237 2.12e-18 81.6 2DNU1@1|root,32Z4S@2|Bacteria,2INE9@201174|Actinobacteria 201174|Actinobacteria S SpoIIAA-like - - - - - - - - - - - - SpoIIAA-like k59_1347617_1 1453501.JELR01000002_gene134 3.71e-122 371.0 COG2730@1|root,COG2730@2|Bacteria,1PY25@1224|Proteobacteria,1SYWJ@1236|Gammaproteobacteria,4666R@72275|Alteromonadaceae 1236|Gammaproteobacteria G CBD_II - - 3.2.1.4 ko:K01179 ko00500,ko01100,map00500,map01100 - R06200,R11307,R11308 - ko00000,ko00001,ko01000 - GH5,GH9 - CBM_10,CBM_2,CBM_5_12_2,Cellulase,Glyco_hydro_11 k59_278593_2 1380393.JHVP01000003_gene811 1.94e-14 72.0 COG4270@1|root,COG4270@2|Bacteria,2GQJP@201174|Actinobacteria 201174|Actinobacteria S DoxX-like family - - - - - - - - - - - - DoxX_2 k59_336238_1 279238.Saro_2597 7.11e-103 303.0 COG4689@1|root,COG4689@2|Bacteria,1RC8T@1224|Proteobacteria,2U7NV@28211|Alphaproteobacteria,2KB59@204457|Sphingomonadales 204457|Sphingomonadales Q Acetoacetate decarboxylase (ADC) - - - - - - - - - - - - ADC k59_336238_2 279238.Saro_2598 1.46e-08 55.1 COG0179@1|root,COG0179@2|Bacteria,1QKVF@1224|Proteobacteria,2U0WP@28211|Alphaproteobacteria,2K43B@204457|Sphingomonadales 204457|Sphingomonadales Q Fumarylacetoacetate (FAA) hydrolase family - - 4.1.1.68 ko:K05921 ko00350,ko01120,ko01220,map00350,map01120,map01220 M00533 R04134,R04380 RC01085,RC02669 ko00000,ko00001,ko00002,ko01000 - - - FAA_hydrolase k59_1180930_1 243233.MCA1608 2.63e-41 152.0 COG2251@1|root,COG2251@2|Bacteria,1QUUG@1224|Proteobacteria,1T3FR@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Domain of unknown function(DUF2779) - - - - - - - - - - - - DUF2779 k59_393328_1 1144275.COCOR_04410 1.57e-26 112.0 COG2303@1|root,COG2303@2|Bacteria,1MU3F@1224|Proteobacteria,42MWP@68525|delta/epsilon subdivisions 1224|Proteobacteria E oxidoreductase - - - - - - - - - - - - FAD_binding_2,GMC_oxred_C,GMC_oxred_N k59_781934_1 983545.Glaag_2662 9.83e-28 112.0 COG4536@1|root,COG4536@2|Bacteria,1NZ99@1224|Proteobacteria,1RNCE@1236|Gammaproteobacteria,464AQ@72275|Alteromonadaceae 1236|Gammaproteobacteria P Mg2 and Co2 transporter CorB yfjD GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - - - - - - - - - - CBS,CorC_HlyC,DUF21 k59_1291532_1 948106.AWZT01000001_gene5225 9.75e-95 298.0 COG2303@1|root,COG2303@2|Bacteria,1MV19@1224|Proteobacteria,2VI6F@28216|Betaproteobacteria,1K0X6@119060|Burkholderiaceae 28216|Betaproteobacteria E Belongs to the GMC oxidoreductase family - - 1.1.99.1 ko:K00108 ko00260,ko01100,map00260,map01100 M00555 R01025 RC00087 ko00000,ko00001,ko00002,ko01000 - - - GMC_oxred_C,GMC_oxred_N k59_1236660_1 1122604.JONR01000058_gene4010 2.26e-67 229.0 COG1201@1|root,COG1201@2|Bacteria,1MUSW@1224|Proteobacteria,1RSNV@1236|Gammaproteobacteria,1X46E@135614|Xanthomonadales 135614|Xanthomonadales L Helicase lhr1 - - ko:K03724 - - - - ko00000,ko01000,ko03400 - - - DEAD,DEAD_assoc,Helicase_C k59_336265_1 384765.SIAM614_19461 3.01e-28 115.0 COG0038@1|root,COG0038@2|Bacteria,1MV4K@1224|Proteobacteria,2TTBG@28211|Alphaproteobacteria 28211|Alphaproteobacteria P Chloride channel - - - ko:K03281 - - - - ko00000 2.A.49 - - CBS,Voltage_CLC k59_1632906_1 977880.RALTA_B1377 1.51e-09 59.7 COG3568@1|root,COG3568@2|Bacteria,1MVN7@1224|Proteobacteria,2VPRV@28216|Betaproteobacteria,1K3CH@119060|Burkholderiaceae 28216|Betaproteobacteria L Endonuclease Exonuclease phosphatase - - - - - - - - - - - - Exo_endo_phos k59_1632906_2 96561.Dole_2521 8.45e-19 87.4 COG0398@1|root,COG1502@1|root,COG0398@2|Bacteria,COG1502@2|Bacteria,1MV8I@1224|Proteobacteria,42MXD@68525|delta/epsilon subdivisions,2WKDU@28221|Deltaproteobacteria,2MMMY@213118|Desulfobacterales 28221|Deltaproteobacteria I Phospholipase D. Active site motifs. - - - - - - - - - - - - PLDc,PLDc_2,SNARE_assoc k59_555353_1 1232683.ADIMK_2017 5.63e-11 65.9 COG0654@1|root,COG0654@2|Bacteria,1MU6I@1224|Proteobacteria,1RND5@1236|Gammaproteobacteria,464US@72275|Alteromonadaceae 1236|Gammaproteobacteria CH COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases ubiF GO:0003674,GO:0003824,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0008682,GO:0009058,GO:0009108,GO:0009987,GO:0016491,GO:0016705,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:1901576,GO:1901661,GO:1901663 - ko:K03184 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00117 R06146,R08775 RC01254 ko00000,ko00001,ko00002,ko01000 - - iAF1260.b0662,iBWG_1329.BWG_0533,iE2348C_1286.E2348C_0555,iECDH10B_1368.ECDH10B_0731,iECDH1ME8569_1439.ECDH1ME8569_0631,iETEC_1333.ETEC_0690,iEcDH1_1363.EcDH1_2964,iEcHS_1320.EcHS_A0709,iJO1366.b0662,iJR904.b0662,iSBO_1134.SBO_0526,iSbBS512_1146.SbBS512_E0585,iUMNK88_1353.UMNK88_700,iY75_1357.Y75_RS03450 FAD_binding_3,SE k59_555353_2 1049564.TevJSym_ak01000 2.42e-25 103.0 COG0006@1|root,COG0006@2|Bacteria,1MUZS@1224|Proteobacteria,1RN0W@1236|Gammaproteobacteria,1J4KM@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E aminopeptidase pepP - 3.4.11.9 ko:K01262 - - - - ko00000,ko01000,ko01002 - - - AMP_N,Peptidase_M24 k59_1070333_1 314285.KT71_04480 1.27e-19 89.4 COG2374@1|root,COG2374@2|Bacteria,1MX52@1224|Proteobacteria,1RMHH@1236|Gammaproteobacteria,1J6AJ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S extracellular nuclease - - - ko:K07004 - - - - ko00000 - - - DUF3616,Endonuclease_1,Exo_endo_phos,LTD k59_1581210_1 857087.Metme_2153 6.58e-38 135.0 COG0835@1|root,COG0835@2|Bacteria,1RD1W@1224|Proteobacteria,1S26J@1236|Gammaproteobacteria,1XEZV@135618|Methylococcales 135618|Methylococcales NT PFAM CheW-like - - - ko:K03408 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - CheW k59_791903_1 1121403.AUCV01000018_gene3164 1.34e-58 207.0 COG1277@1|root,COG3225@1|root,COG1277@2|Bacteria,COG3225@2|Bacteria,1NZZ9@1224|Proteobacteria,42SH9@68525|delta/epsilon subdivisions,2WPWW@28221|Deltaproteobacteria,2MIHA@213118|Desulfobacterales 28221|Deltaproteobacteria N ABC-2 family transporter protein - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_2,ABC2_membrane_3,ABC_transp_aux k59_1074084_1 1245471.PCA10_50020 8.58e-43 160.0 COG2132@1|root,COG2132@2|Bacteria,1N9H3@1224|Proteobacteria 1224|Proteobacteria Q Multicopper oxidase - - 1.16.3.3 ko:K22349 - - - - ko00000,ko01000 - - - - k59_1582660_1 639283.Snov_3370 1.53e-58 203.0 COG1529@1|root,COG1529@2|Bacteria,1QTTJ@1224|Proteobacteria,2TQVK@28211|Alphaproteobacteria,3EYJ8@335928|Xanthobacteraceae 28211|Alphaproteobacteria C Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain iorB - 1.3.99.16 ko:K07303 - - - - ko00000,ko01000 - - - Ald_Xan_dh_C2 k59_1582660_2 1101190.ARWB01000001_gene2386 5.62e-30 110.0 COG2080@1|root,COG2080@2|Bacteria,1RD8C@1224|Proteobacteria,2U6Z6@28211|Alphaproteobacteria,3705T@31993|Methylocystaceae 28211|Alphaproteobacteria C [2Fe-2S] binding domain iorA - 1.3.99.16 ko:K07302 - - - - ko00000,ko01000 - - - Fer2,Fer2_2 k59_509237_1 1303518.CCALI_00801 3.28e-49 168.0 COG0667@1|root,COG0667@2|Bacteria 2|Bacteria C Aldo Keto reductase - - 1.1.1.91 ko:K05882 - - - - ko00000,ko01000 - - - Aldo_ket_red k59_113824_2 436308.Nmar_0598 2.14e-109 317.0 COG2101@1|root,arCOG01764@2157|Archaea,41SZD@651137|Thaumarchaeota 651137|Thaumarchaeota K General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation - - - ko:K03120 ko03022,ko05016,ko05165,ko05166,ko05168,ko05169,ko05203,map03022,map05016,map05165,map05166,map05168,map05169,map05203 - - - ko00000,ko00001,ko03000,ko03021 - - - TBP k59_805_1 768671.ThimaDRAFT_0621 3.32e-63 213.0 COG1297@1|root,COG1297@2|Bacteria,1N7SK@1224|Proteobacteria,1RNC8@1236|Gammaproteobacteria,1WXBI@135613|Chromatiales 135613|Chromatiales S oligopeptide transporter - - - - - - - - - - - - OPT k59_452647_1 187272.Mlg_0248 1.59e-08 54.7 COG0492@1|root,COG0492@2|Bacteria,1MV15@1224|Proteobacteria,1RMEX@1236|Gammaproteobacteria,1WWPK@135613|Chromatiales 135613|Chromatiales C Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family - - 1.8.1.9 ko:K00384 ko00450,map00450 - R02016,R03596,R09372 RC00013,RC02518,RC02873 ko00000,ko00001,ko01000 - - - Pyr_redox_2 k59_735401_1 1122137.AQXF01000004_gene1548 0.000542 42.4 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2TQPG@28211|Alphaproteobacteria 28211|Alphaproteobacteria T COG2204 Response regulator containing CheY-like receiver AAA-type ATPase and DNA-binding domains tacA GO:0003674,GO:0003700,GO:0004857,GO:0006355,GO:0008073,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0010967,GO:0019219,GO:0019222,GO:0030234,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0033238,GO:0042979,GO:0043086,GO:0044092,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050790,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0065009,GO:0080090,GO:0098772,GO:0140110,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141 - - - - - - - - - - HTH_8,Response_reg,Sigma54_activ_2,Sigma54_activat k59_735401_2 1122137.AQXF01000004_gene1549 2.95e-139 403.0 COG3288@1|root,COG3288@2|Bacteria,1MVXU@1224|Proteobacteria,2TSZN@28211|Alphaproteobacteria 28211|Alphaproteobacteria C The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane pntAA GO:0000166,GO:0003674,GO:0003824,GO:0003957,GO:0005215,GO:0005488,GO:0005515,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006740,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0008746,GO:0008750,GO:0009117,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015672,GO:0016491,GO:0016651,GO:0016652,GO:0019362,GO:0019637,GO:0022857,GO:0022890,GO:0034220,GO:0034641,GO:0036094,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0046496,GO:0046983,GO:0048037,GO:0050662,GO:0051179,GO:0051186,GO:0051234,GO:0051287,GO:0055085,GO:0055086,GO:0055114,GO:0070403,GO:0070404,GO:0071704,GO:0072524,GO:0097159,GO:0098655,GO:0098660,GO:0098662,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1902600 1.6.1.2 ko:K00324 ko00760,ko01100,map00760,map01100 - R00112 RC00001 ko00000,ko00001,ko01000 - - - AlaDh_PNT_C,AlaDh_PNT_N k59_1752169_1 1265313.HRUBRA_02063 8.36e-142 425.0 COG0550@1|root,COG0550@2|Bacteria,1MUFZ@1224|Proteobacteria,1RNZ2@1236|Gammaproteobacteria,1J526@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone topA GO:0003674,GO:0003824,GO:0003916,GO:0003917,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006265,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0016853,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051276,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360 5.99.1.2 ko:K03168 - - - - ko00000,ko01000,ko03032,ko03400 - - - Topo_Zn_Ribbon,Topoisom_bac,Toprim,Toprim_C_rpt,zf-C4_Topoisom k59_1243714_1 859657.RPSI07_2236 7.8e-70 219.0 COG0613@1|root,COG0613@2|Bacteria,1MWIH@1224|Proteobacteria,2VHB2@28216|Betaproteobacteria,1K1H7@119060|Burkholderiaceae 28216|Betaproteobacteria S SMART phosphoesterase PHP domain protein - GO:0003674,GO:0003824,GO:0005488,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0030145,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0046872,GO:0046914,GO:0097657 3.1.3.97 ko:K07053 - - R00188,R11188 RC00078 ko00000,ko01000 - - - PHP k59_1243714_2 1121004.ATVC01000006_gene1291 2.16e-36 128.0 COG0009@1|root,COG0009@2|Bacteria,1MVPM@1224|Proteobacteria,2VH4T@28216|Betaproteobacteria,2KQ0A@206351|Neisseriales 206351|Neisseriales J Belongs to the SUA5 family yciO - - - - - - - - - - - Sua5_yciO_yrdC k59_1017956_1 551275.KB899550_gene659 7.01e-34 134.0 COG2010@1|root,COG2010@2|Bacteria,1QVQX@1224|Proteobacteria,2TYUE@28211|Alphaproteobacteria,43ZDI@69657|Hyphomonadaceae 28211|Alphaproteobacteria C Protein of unknown function (DUF1595) - - - - - - - - - - - - PSCyt3,PSD2,PSD3,PSD4,PSD5 k59_1695565_1 1121937.AUHJ01000008_gene2029 3.04e-93 276.0 COG1999@1|root,COG1999@2|Bacteria,1RHSV@1224|Proteobacteria,1S6HW@1236|Gammaproteobacteria,46751@72275|Alteromonadaceae 1236|Gammaproteobacteria S protein SCO1 SenC PrrC, involved in biogenesis of respiratory and photosynthetic systems scoP - - ko:K07152 - - - - ko00000,ko03029 - - - SCO1-SenC k59_452657_1 385682.AFSL01000006_gene2333 1.08e-19 83.2 COG0432@1|root,COG0432@2|Bacteria,4NUS2@976|Bacteroidetes,2FW13@200643|Bacteroidia,3XK30@558415|Marinilabiliaceae 976|Bacteroidetes S Uncharacterised protein family UPF0047 - - - - - - - - - - - - UPF0047 k59_339897_1 1265313.HRUBRA_02301 5.68e-62 207.0 COG0204@1|root,COG0560@1|root,COG0204@2|Bacteria,COG0560@2|Bacteria,1MY51@1224|Proteobacteria,1RQYC@1236|Gammaproteobacteria,1J8AD@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria I Phosphate acyltransferases - - - - - - - - - - - - Acyltransferase,HAD k59_1413205_1 926569.ANT_00470 6.3e-62 196.0 COG0500@1|root,COG2226@2|Bacteria,2G780@200795|Chloroflexi 200795|Chloroflexi Q PFAM Methyltransferase type 11 - - - - - - - - - - - - Methyltransf_11 k59_1413209_1 1122134.KB893651_gene1769 3.25e-30 110.0 COG0222@1|root,COG0222@2|Bacteria,1RGU4@1224|Proteobacteria,1S5V7@1236|Gammaproteobacteria,1XJXD@135619|Oceanospirillales 135619|Oceanospirillales J Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation rplL - - ko:K02935 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L12,Ribosomal_L12_N k59_1413209_2 203122.Sde_0922 1.67e-34 122.0 COG0244@1|root,COG0244@2|Bacteria,1RAN5@1224|Proteobacteria,1S286@1236|Gammaproteobacteria,46765@72275|Alteromonadaceae 1236|Gammaproteobacteria J Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors rplJ GO:0003674,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006417,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015934,GO:0017148,GO:0019222,GO:0019538,GO:0022625,GO:0022626,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0044877,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:1901564,GO:1901566,GO:1901576,GO:1990904,GO:2000112,GO:2000113 - ko:K02864 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L10 k59_1753560_1 537970.HCAN_1239 7.4e-14 74.3 COG1802@1|root,COG1802@2|Bacteria,1NDRT@1224|Proteobacteria,42UIV@68525|delta/epsilon subdivisions,2YPW8@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria K Pfam matches to PF07729.7 FCD, and to PF00392.16 GntR - - - - - - - - - - - - FCD,GntR k59_1527717_1 765914.ThisiDRAFT_1029 2.57e-44 160.0 COG1138@1|root,COG1138@2|Bacteria,1MUQS@1224|Proteobacteria,1RMY5@1236|Gammaproteobacteria,1WWM9@135613|Chromatiales 135613|Chromatiales O Cytochrome c-type biogenesis protein - - - ko:K02198 - - - - ko00000,ko02000 9.B.14.1 - - CcmF_C,Cytochrom_C_asm k59_1527717_2 351348.Maqu_1956 1.28e-29 110.0 COG2332@1|root,COG2332@2|Bacteria,1RHN5@1224|Proteobacteria,1S5VA@1236|Gammaproteobacteria,467DA@72275|Alteromonadaceae 1236|Gammaproteobacteria O Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH ccmE GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006807,GO:0006810,GO:0008150,GO:0008152,GO:0009897,GO:0009986,GO:0009987,GO:0015886,GO:0016020,GO:0016043,GO:0017003,GO:0017004,GO:0017006,GO:0018063,GO:0019538,GO:0020037,GO:0022607,GO:0031224,GO:0031226,GO:0031233,GO:0031237,GO:0034622,GO:0036211,GO:0043170,GO:0043412,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0046906,GO:0048037,GO:0051179,GO:0051181,GO:0051234,GO:0065003,GO:0071702,GO:0071704,GO:0071705,GO:0071840,GO:0071944,GO:0097159,GO:0098552,GO:0098567,GO:1901363,GO:1901564,GO:1901678 - ko:K02197 - - - - ko00000 - - iSSON_1240.SSON_2255 CcmE k59_1697144_1 1229909.NSED_03230 2.12e-170 488.0 arCOG08742@1|root,arCOG08742@2157|Archaea,41SS8@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_59102_1 96561.Dole_0941 2.12e-66 214.0 COG0444@1|root,COG0444@2|Bacteria,1R4KB@1224|Proteobacteria,42M3F@68525|delta/epsilon subdivisions,2WJ32@28221|Deltaproteobacteria,2MIH7@213118|Desulfobacterales 28221|Deltaproteobacteria EP Belongs to the ABC transporter superfamily - - - ko:K02031 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - ABC_tran,oligo_HPY k59_59102_2 1298593.TOL_1407 4.63e-22 95.9 COG1173@1|root,COG1173@2|Bacteria,1MW8H@1224|Proteobacteria,1T3SA@1236|Gammaproteobacteria,1XRVH@135619|Oceanospirillales 135619|Oceanospirillales U Binding-protein-dependent transport system inner membrane component - - - ko:K02034 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1 k59_2297_1 997346.HMPREF9374_1910 3.11e-05 47.8 COG1132@1|root,COG1132@2|Bacteria,1TP0B@1239|Firmicutes,4HA3S@91061|Bacilli,27AWI@186824|Thermoactinomycetaceae 91061|Bacilli V ABC superfamily ATP binding cassette transporter, ABC yfiC - - ko:K06147 - - - - ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran k59_2297_2 1122211.JMLW01000017_gene1581 1.02e-27 111.0 COG4591@1|root,COG4591@2|Bacteria,1MVV7@1224|Proteobacteria,1RMP9@1236|Gammaproteobacteria,1XHFB@135619|Oceanospirillales 135619|Oceanospirillales M Lipoprotein releasing system, transmembrane protein lolC - - ko:K09808 ko02010,map02010 M00255 - - ko00000,ko00001,ko00002,ko02000 3.A.1.125 - - FtsX,MacB_PCD k59_1188736_1 1545915.JROG01000004_gene2206 1.14e-85 264.0 COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,2TS1R@28211|Alphaproteobacteria,2JZW6@204457|Sphingomonadales 204457|Sphingomonadales I Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation - - 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N k59_1075461_1 243159.AFE_2760 3.25e-29 113.0 COG0216@1|root,COG0216@2|Bacteria,1MV28@1224|Proteobacteria,1RM7Q@1236|Gammaproteobacteria,2NCGH@225057|Acidithiobacillales 225057|Acidithiobacillales J Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA prfA - - ko:K02835 - - - - ko00000,ko03012 - - - PCRF,RF-1 k59_1075461_2 1121366.KB892438_gene626 3.08e-10 65.9 COG1403@1|root,COG1403@2|Bacteria,2HAHI@201174|Actinobacteria,22M06@1653|Corynebacteriaceae 201174|Actinobacteria V HNH endonuclease - - - - - - - - - - - - DUF222,HNH k59_680238_1 1088721.NSU_0378 1.15e-10 60.8 COG2013@1|root,COG2013@2|Bacteria,1NBBE@1224|Proteobacteria,2TU3J@28211|Alphaproteobacteria,2K2YB@204457|Sphingomonadales 204457|Sphingomonadales S Mitochondrial biogenesis AIM24 - - - - - - - - - - - - AIM24 k59_1245356_1 1123371.ATXH01000029_gene42 3.18e-46 172.0 COG1200@1|root,COG1200@2|Bacteria,2GHAE@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria L Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) recG - 3.6.4.12 ko:K03655 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,Helicase_C,RecG_wedge k59_341541_1 1139996.OMQ_01913 3.82e-38 139.0 COG0142@1|root,COG0142@2|Bacteria,1TPQY@1239|Firmicutes,4HA8E@91061|Bacilli,4AZBE@81852|Enterococcaceae 91061|Bacilli H Belongs to the FPP GGPP synthase family ispA GO:0003674,GO:0003824,GO:0004659,GO:0005575,GO:0005622,GO:0005623,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016740,GO:0016765,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044464,GO:0071704,GO:1901576 2.5.1.1,2.5.1.10,2.5.1.29 ko:K13789 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00364,M00366 R01658,R02003,R02061 RC00279 ko00000,ko00001,ko00002,ko01000,ko01006 - - - polyprenyl_synt k59_849814_1 156889.Mmc1_0229 2.18e-74 236.0 COG0306@1|root,COG0306@2|Bacteria,1MVXK@1224|Proteobacteria,2TSYI@28211|Alphaproteobacteria 28211|Alphaproteobacteria P Phosphate pit - - ko:K03306 - - - - ko00000 2.A.20 - - PHO4 k59_397896_1 926569.ANT_08490 6.12e-50 164.0 COG1664@1|root,COG1664@2|Bacteria,2G7DZ@200795|Chloroflexi 200795|Chloroflexi M Polymer-forming cytoskeletal - - - - - - - - - - - - Bactofilin k59_623761_1 1178482.BJB45_08335 4.87e-27 107.0 COG0389@1|root,COG0389@2|Bacteria,1MUUH@1224|Proteobacteria,1RMT1@1236|Gammaproteobacteria,1XH3E@135619|Oceanospirillales 135619|Oceanospirillales L DNA polymerase umuC - - ko:K03502 - - - - ko00000,ko03400 - - - DUF4113,IMS,IMS_C,IMS_HHH k59_623761_2 1178482.BJB45_08340 2.09e-66 205.0 COG1974@1|root,COG1974@2|Bacteria,1MZFA@1224|Proteobacteria,1S5X5@1236|Gammaproteobacteria,1XKVV@135619|Oceanospirillales 135619|Oceanospirillales KT Belongs to the peptidase S24 family - - - ko:K03503 - - - - ko00000,ko01000,ko01002,ko03400 - - - Peptidase_S24 k59_623761_3 1178482.BJB45_08345 1.85e-49 164.0 COG2135@1|root,COG2135@2|Bacteria,1RCCC@1224|Proteobacteria,1S39B@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Belongs to the SOS response-associated peptidase family - - - - - - - - - - - - SRAP k59_510747_1 215803.DB30_5153 3.87e-07 50.4 COG2805@1|root,COG2805@2|Bacteria,1MU3J@1224|Proteobacteria,42M7F@68525|delta/epsilon subdivisions,2WIMF@28221|Deltaproteobacteria,2YWXD@29|Myxococcales 28221|Deltaproteobacteria NU twitching motility protein pilT-4 - - ko:K02669 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE k59_510747_2 335543.Sfum_0117 4.74e-101 311.0 COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,42M51@68525|delta/epsilon subdivisions,2WIPP@28221|Deltaproteobacteria,2MQ93@213462|Syntrophobacterales 28221|Deltaproteobacteria NU TIGRFAM type IV-A pilus assembly ATPase PilB pilB - - ko:K02652 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE,T2SSE_N,cNMP_binding k59_1640789_1 1123367.C666_01495 3.82e-36 140.0 COG2902@1|root,COG2902@2|Bacteria,1MXNV@1224|Proteobacteria,2VKIR@28216|Betaproteobacteria,2KVIK@206389|Rhodocyclales 206389|Rhodocyclales E Bacterial NAD-glutamate dehydrogenase gdh - 1.4.1.2 ko:K15371 ko00220,ko00250,ko00430,ko00910,ko01100,map00220,map00250,map00430,map00910,map01100 - R00243 RC00006,RC02799 ko00000,ko00001,ko01000 - - - Bac_GDH k59_285075_2 349124.Hhal_0448 1.04e-15 80.9 COG1638@1|root,COG1638@2|Bacteria,1PER4@1224|Proteobacteria,1RQBK@1236|Gammaproteobacteria 1236|Gammaproteobacteria G TRAP dicarboxylate transporter DctP subunit - - - - - - - - - - - - DctP k59_1301926_1 273526.SMDB11_3988 2.92e-19 88.6 COG0606@1|root,COG0606@2|Bacteria,1MU4R@1224|Proteobacteria,1RMB9@1236|Gammaproteobacteria,401I9@613|Serratia 1236|Gammaproteobacteria O Among the AAA ATPases, the YifB protease family belongs to the Helix 2 insert clade comM GO:0003674,GO:0003824,GO:0004176,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019538,GO:0042623,GO:0043170,GO:0044238,GO:0070011,GO:0071704,GO:0140096,GO:1901564 - ko:K07391 - - - - ko00000 - - - ChlI,Mg_chelatase,Mg_chelatase_C k59_567557_2 436308.Nmar_1254 1.92e-85 253.0 COG1632@1|root,arCOG04209@2157|Archaea,41SND@651137|Thaumarchaeota 651137|Thaumarchaeota J Ribosomal protein L15E - - - ko:K02877 ko03010,map03010 M00177,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L15e k59_1753615_1 105559.Nwat_2257 3.35e-28 112.0 COG0504@1|root,COG0504@2|Bacteria,1MUIT@1224|Proteobacteria,1RM92@1236|Gammaproteobacteria,1WWJ8@135613|Chromatiales 135613|Chromatiales F Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates pyrG - 6.3.4.2 ko:K01937 ko00240,ko01100,map00240,map01100 M00052 R00571,R00573 RC00010,RC00074 ko00000,ko00001,ko00002,ko01000 - - - CTP_synth_N,GATase k59_1753615_2 314278.NB231_01369 6.17e-10 60.5 COG0037@1|root,COG0037@2|Bacteria,1MU85@1224|Proteobacteria,1RN14@1236|Gammaproteobacteria,1WWPM@135613|Chromatiales 135613|Chromatiales D Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine tilS - 6.3.4.19 ko:K04075 - - R09597 RC02633,RC02634 ko00000,ko01000,ko03016 - - - ATP_bind_3,TilS,TilS_C k59_1132244_1 1121939.L861_01740 8.99e-72 229.0 COG2072@1|root,COG2072@2|Bacteria,1MWPJ@1224|Proteobacteria,1RNQP@1236|Gammaproteobacteria 1236|Gammaproteobacteria P oxidoreductase - - - ko:K07222 - - - - ko00000 - - - Pyr_redox_3 k59_1358371_1 247634.GPB2148_2792 2.43e-54 181.0 COG1215@1|root,COG1215@2|Bacteria,1MWH9@1224|Proteobacteria,1RPTN@1236|Gammaproteobacteria,1J4WS@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M COG0463 Glycosyltransferases involved in cell wall biogenesis - - 2.4.1.266 ko:K13693 - - - - ko00000,ko01000,ko01003 - GT81 - - k59_1132251_1 555793.WSK_0887 1.71e-13 70.1 COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,2TUFK@28211|Alphaproteobacteria,2K0NW@204457|Sphingomonadales 204457|Sphingomonadales M RND efflux system, outer membrane lipoprotein - - - ko:K18139 ko01501,ko02024,map01501,map02024 M00642,M00643,M00647,M00718,M00768,M00822 - - ko00000,ko00001,ko00002,ko01504,ko02000 1.B.17,2.A.6.2 - - OEP k59_1132251_2 1088721.NSU_4051 4.08e-22 91.7 COG1846@1|root,COG1846@2|Bacteria,1NXEA@1224|Proteobacteria,2UTY7@28211|Alphaproteobacteria,2KAKT@204457|Sphingomonadales 204457|Sphingomonadales K helix_turn_helix multiple antibiotic resistance protein - - - - - - - - - - - - MarR_2 k59_1527771_1 1415778.JQMM01000001_gene1759 1.69e-79 253.0 COG0405@1|root,COG0405@2|Bacteria,1MUV6@1224|Proteobacteria,1RMIT@1236|Gammaproteobacteria,1J5I7@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M COG0405 Gamma-glutamyltransferase ggt GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0006082,GO:0006508,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0008242,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016787,GO:0019538,GO:0019752,GO:0030288,GO:0030313,GO:0031975,GO:0034722,GO:0036374,GO:0042597,GO:0043094,GO:0043102,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0070011,GO:0071704,GO:0097264,GO:0140096,GO:1901564,GO:1901566,GO:1901576 2.3.2.2,3.4.19.13 ko:K00681 ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100 - R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935 RC00064,RC00090,RC00096 ko00000,ko00001,ko01000,ko01002 - - iAPECO1_1312.APECO1_3012,iECOK1_1307.ECOK1_3869,iECS88_1305.ECS88_3844,iECW_1372.ECW_m3706,iEKO11_1354.EKO11_0296,iETEC_1333.ETEC_3693,iUMN146_1321.UM146_17325,iUTI89_1310.UTI89_C3954,iWFL_1372.ECW_m3706 G_glu_transpept k59_1245427_1 1122137.AQXF01000006_gene733 8.72e-59 187.0 COG2716@1|root,COG2716@2|Bacteria,1RM4T@1224|Proteobacteria,2UBAI@28211|Alphaproteobacteria 28211|Alphaproteobacteria E regulation of RNA biosynthetic process - - - ko:K03567 ko02026,map02026 - - - ko00000,ko00001,ko03000 - - - ACT_6 k59_1245427_2 1122137.AQXF01000006_gene732 1.28e-98 290.0 COG2854@1|root,COG2854@2|Bacteria 2|Bacteria Q intermembrane phospholipid transfer ttg2D - - ko:K07323 ko02010,map02010 M00210 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27.3 - - MlaC k59_341581_2 1380393.JHVP01000013_gene3363 8.32e-62 209.0 COG0772@1|root,COG0772@2|Bacteria,2GJTI@201174|Actinobacteria,4ERWV@85013|Frankiales 201174|Actinobacteria D Belongs to the SEDS family rodA GO:0002682,GO:0002684,GO:0008150,GO:0009605,GO:0009607,GO:0009987,GO:0035821,GO:0043207,GO:0044003,GO:0044403,GO:0044419,GO:0048518,GO:0048583,GO:0048584,GO:0050776,GO:0050778,GO:0050789,GO:0050896,GO:0051301,GO:0051701,GO:0051704,GO:0051707,GO:0051817,GO:0052031,GO:0052173,GO:0052200,GO:0052255,GO:0052552,GO:0052553,GO:0052555,GO:0052556,GO:0052564,GO:0052572,GO:0065007,GO:0075136 - ko:K03588 ko04112,map04112 - - - ko00000,ko00001,ko02000,ko03036 2.A.103.1 - - FTSW_RODA_SPOVE k59_1753639_1 666509.RCA23_c28360 2.31e-90 280.0 COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,2TR4Q@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Protein conserved in bacteria - - - ko:K07793 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.80.1 - - TctA k59_962790_1 1415778.JQMM01000001_gene2247 6.9e-59 188.0 COG4660@1|root,COG4660@2|Bacteria,1MW6N@1224|Proteobacteria,1RMEH@1236|Gammaproteobacteria,1J525@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Part of a membrane complex involved in electron transport rnfE GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008152,GO:0016020,GO:0016021,GO:0016491,GO:0016651,GO:0031224,GO:0044425,GO:0044464,GO:0055114,GO:0071944 - ko:K03613 - - - - ko00000 - - - Rnf-Nqr k59_1358393_1 1298867.AUES01000041_gene897 1.27e-84 259.0 COG0604@1|root,COG0604@2|Bacteria,1MX8A@1224|Proteobacteria,2TYVX@28211|Alphaproteobacteria,3JWZ3@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria C Zinc-binding dehydrogenase - - - - - - - - - - - - ADH_N,ADH_zinc_N,ADH_zinc_N_2 k59_623824_1 1122194.AUHU01000014_gene1193 9.02e-15 79.7 COG0457@1|root,COG0457@2|Bacteria,1MVCA@1224|Proteobacteria,1RS02@1236|Gammaproteobacteria,464BM@72275|Alteromonadaceae 1236|Gammaproteobacteria S COG0457 FOG TPR repeat - - - - - - - - - - - - ANAPC3,TPR_16,TPR_8 k59_737165_1 158500.BV97_03600 1.25e-28 114.0 COG1298@1|root,COG1298@2|Bacteria,1MUF3@1224|Proteobacteria,2TQUR@28211|Alphaproteobacteria,2K2PH@204457|Sphingomonadales 204457|Sphingomonadales N Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin flhA - - ko:K02400 ko02040,map02040 - - - ko00000,ko00001,ko02035,ko02044 3.A.6.2,3.A.6.3 - - FHIPEP k59_737165_2 1096930.L284_05300 4.07e-39 136.0 COG2204@1|root,COG2204@2|Bacteria,1NHCV@1224|Proteobacteria,2UJM9@28211|Alphaproteobacteria,2K61W@204457|Sphingomonadales 204457|Sphingomonadales T Bacterial regulatory protein, Fis family - - - - - - - - - - - - HTH_8 k59_737165_3 1144305.PMI02_03608 6.19e-47 154.0 COG1886@1|root,COG1886@2|Bacteria,1RGWT@1224|Proteobacteria,2UC6U@28211|Alphaproteobacteria,2K5NI@204457|Sphingomonadales 204457|Sphingomonadales N FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation - - - ko:K02417 ko02030,ko02040,map02030,map02040 - - - ko00000,ko00001,ko02035,ko02044 3.A.6.2,3.A.6.3 - - FliMN_C k59_1301973_1 398767.Glov_0670 9.23e-25 108.0 COG0707@1|root,COG0707@2|Bacteria,1MVIB@1224|Proteobacteria,42ME1@68525|delta/epsilon subdivisions,2WJNY@28221|Deltaproteobacteria,43UB0@69541|Desulfuromonadales 28221|Deltaproteobacteria M Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) murG - 2.4.1.227 ko:K02563 ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112 - R05032,R05662 RC00005,RC00049 ko00000,ko00001,ko01000,ko01011 - GT28 - Glyco_tran_28_C,Glyco_transf_28 k59_906091_2 1288494.EBAPG3_26670 1.05e-51 174.0 COG2064@1|root,COG2064@2|Bacteria,1MWAZ@1224|Proteobacteria,2VIA4@28216|Betaproteobacteria,3742J@32003|Nitrosomonadales 28216|Betaproteobacteria NU Type II secretion system (T2SS), protein F tadC - - ko:K12511 - - - - ko00000,ko02044 - - - T2SSF k59_59186_1 77586.LPERR03G02490.1 1.2e-20 95.9 COG0110@1|root,COG0318@1|root,KOG1176@2759|Eukaryota,KOG4750@2759|Eukaryota,37NZS@33090|Viridiplantae,3G7PF@35493|Streptophyta,3KVN5@4447|Liliopsida,3IF41@38820|Poales 35493|Streptophyta I AMP-binding enzyme - GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005777,GO:0042579,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464 - ko:K00666 - - - - ko00000,ko01000,ko01004 - - - AMP-binding,AMP-binding_C k59_115739_1 1229909.NSED_04595 2.04e-90 277.0 COG0498@1|root,arCOG01434@2157|Archaea,41S5N@651137|Thaumarchaeota 651137|Thaumarchaeota E Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine - - 4.2.3.1 ko:K01733 ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230 M00018 R01466,R05086 RC00017,RC00526 ko00000,ko00001,ko00002,ko01000 - - - PALP k59_1310649_1 1198232.CYCME_2291 8.21e-69 219.0 COG0275@1|root,COG0275@2|Bacteria,1MUT4@1224|Proteobacteria,1RM7M@1236|Gammaproteobacteria,4603X@72273|Thiotrichales 72273|Thiotrichales J Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA rsmH - 2.1.1.199 ko:K03438 - - - - ko00000,ko01000,ko03009 - - - Methyltransf_5 k59_1480590_1 1123250.KB908396_gene1814 2.39e-113 338.0 COG0436@1|root,COG0436@2|Bacteria,1TQD6@1239|Firmicutes,4H1Y0@909932|Negativicutes 909932|Negativicutes E Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate dapL - 2.6.1.83 ko:K10206 ko00300,ko01100,ko01110,ko01130,ko01230,map00300,map01100,map01110,map01130,map01230 M00527 R07613 RC00006,RC01847 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 k59_970940_1 1163409.UUA_11748 3.61e-63 204.0 COG0626@1|root,COG0626@2|Bacteria,1MU57@1224|Proteobacteria,1RMCV@1236|Gammaproteobacteria,1X4AH@135614|Xanthomonadales 135614|Xanthomonadales E cystathionine - - 4.4.1.1 ko:K01758 ko00260,ko00270,ko00450,ko01100,ko01130,ko01230,map00260,map00270,map00450,map01100,map01130,map01230 M00338 R00782,R01001,R02408,R04770,R04930,R09366 RC00056,RC00069,RC00348,RC00382,RC00710,RC01209,RC01210,RC01245,RC02303 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Cys_Met_Meta_PP k59_1480597_1 713586.KB900536_gene1819 4.13e-66 213.0 COG1622@1|root,COG1622@2|Bacteria,1MWHZ@1224|Proteobacteria,1RP4H@1236|Gammaproteobacteria,1WX49@135613|Chromatiales 135613|Chromatiales C Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) - - 1.9.3.1 ko:K02275 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.4,3.D.4.6 - - COX2,COX2_TM,Cytochrome_CBB3 k59_745444_1 1280944.HY17_06035 1.45e-43 152.0 COG1073@1|root,COG1073@2|Bacteria,1NX52@1224|Proteobacteria,2TSJM@28211|Alphaproteobacteria 28211|Alphaproteobacteria I Alpha beta hydrolase - - - - - - - - - - - - Abhydrolase_6 k59_745444_2 405948.SACE_1028 3.34e-39 144.0 COG1024@1|root,COG1024@2|Bacteria,2GJDK@201174|Actinobacteria,4DYVB@85010|Pseudonocardiales 201174|Actinobacteria I PFAM Enoyl-CoA hydratase isomerase chcB - 5.3.3.18 ko:K15866 ko00360,ko01120,map00360,map01120 - R09837,R09839 RC00004,RC00326,RC02689,RC03003 ko00000,ko00001,ko01000 - - - ECH_1 k59_1254171_1 436308.Nmar_1629 2.9e-07 47.4 arCOG08792@1|root,arCOG08792@2157|Archaea,41SUG@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1254171_2 436308.Nmar_1630 1.94e-69 211.0 COG1545@1|root,arCOG01285@2157|Archaea,41SQK@651137|Thaumarchaeota 651137|Thaumarchaeota V nucleic-acid-binding protein containing a Zn-ribbon - - - ko:K07068 - - - - ko00000 - - - DUF35_N,OB_aCoA_assoc k59_1536510_1 1121918.ARWE01000001_gene2506 1.81e-100 309.0 COG2225@1|root,COG2225@2|Bacteria,1MVEV@1224|Proteobacteria 1224|Proteobacteria C Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA aceB GO:0003674,GO:0003824,GO:0004474,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0006081,GO:0006082,GO:0006097,GO:0008150,GO:0008152,GO:0009987,GO:0016740,GO:0016746,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044424,GO:0044464,GO:0046487,GO:0046912,GO:0071704 2.3.3.9 ko:K01638 ko00620,ko00630,ko01100,ko01110,ko01120,ko01200,map00620,map00630,map01100,map01110,map01120,map01200 M00012 R00472 RC00004,RC00308,RC02747 ko00000,ko00001,ko00002,ko01000 - - iEC55989_1330.EC55989_4499,iLF82_1304.LF82_0013,iNRG857_1313.NRG857_20010 Malate_synthase k59_632309_1 1005048.CFU_3310 1.34e-16 82.8 COG3240@1|root,COG3240@2|Bacteria,1R3US@1224|Proteobacteria,2WEQC@28216|Betaproteobacteria 28216|Betaproteobacteria I GDSL-like Lipase/Acylhydrolase family - - - ko:K11018 - - - - ko00000,ko02042 - - - Lipase_GDSL k59_914909_1 56780.SYN_00176 6.28e-44 157.0 COG0646@1|root,COG0685@1|root,COG0646@2|Bacteria,COG0685@2|Bacteria,1NPFY@1224|Proteobacteria,42PRW@68525|delta/epsilon subdivisions,2WIMG@28221|Deltaproteobacteria 28221|Deltaproteobacteria H homocysteine S-methyltransferase metF-2 - 1.5.1.20,2.1.1.10 ko:K00297,ko:K00547 ko00270,ko00670,ko00720,ko01100,ko01110,ko01120,ko01200,ko01523,map00270,map00670,map00720,map01100,map01110,map01120,map01200,map01523 M00377 R00650,R01224,R07168 RC00003,RC00035,RC00081 ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_0504 MTHFR,S-methyl_trans k59_914909_2 1196324.A374_02789 5.15e-07 49.7 COG0509@1|root,COG0509@2|Bacteria,1V6WV@1239|Firmicutes,4HIMA@91061|Bacilli 91061|Bacilli E Is also involved in protein lipoylation via its role as an octanoyl lipoyl carrier protein intermediate gcvH GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009106,GO:0009107,GO:0009108,GO:0009249,GO:0009987,GO:0010467,GO:0016053,GO:0018065,GO:0018130,GO:0018193,GO:0018205,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0051604,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901576 - ko:K02437 ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200 M00532 R01221 RC00022,RC02834 ko00000,ko00001,ko00002 - - - GCV_H k59_350475_1 935548.KI912159_gene3804 2.11e-69 225.0 COG0031@1|root,COG0517@1|root,COG0031@2|Bacteria,COG0517@2|Bacteria,1MUBE@1224|Proteobacteria,2TT3E@28211|Alphaproteobacteria,43NW9@69277|Phyllobacteriaceae 28211|Alphaproteobacteria E Pyridoxal-phosphate dependent enzyme - - 4.2.1.22 ko:K01697 ko00260,ko00270,ko01100,ko01130,ko01230,map00260,map00270,map01100,map01130,map01230 M00035,M00338 R00891,R01290,R04942 RC00056,RC00069,RC00256,RC00489,RC01246 ko00000,ko00001,ko00002,ko01000 - - - CBS,PALP k59_1310690_2 1189612.A33Q_3451 7.12e-75 231.0 COG2801@1|root,COG2801@2|Bacteria,4NF3Q@976|Bacteroidetes,47NB8@768503|Cytophagia 976|Bacteroidetes L Integrase core domain - - - ko:K07497 - - - - ko00000 - - - HTH_21,HTH_Tnp_1,rve,rve_3 k59_1367265_1 243365.CV_2032 2.53e-58 195.0 COG0617@1|root,COG0617@2|Bacteria,1MU2X@1224|Proteobacteria,2VIN5@28216|Betaproteobacteria,2KPH1@206351|Neisseriales 206351|Neisseriales J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. Also shows phosphatase, 2'- nucleotidase and 2',3'-cyclic phosphodiesterase activities. These phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases cca - 2.7.7.72 ko:K00974 ko03013,map03013 - R09382,R09383,R09384,R09386 RC00078 ko00000,ko00001,ko01000,ko03016 - - - HD,PolyA_pol,PolyA_pol_RNAbd k59_1084373_1 930169.B5T_02940 3.61e-93 298.0 COG3383@1|root,COG3383@2|Bacteria,1QTZB@1224|Proteobacteria,1T1JA@1236|Gammaproteobacteria,1XIGX@135619|Oceanospirillales 135619|Oceanospirillales C formate dehydrogenase fdsA - 1.17.1.9 ko:K00123 ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200 - R00519 RC02796 ko00000,ko00001,ko01000 - - - Fer2_4,Fer4,Fer4_7,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3 k59_914925_1 207559.Dde_0151 9.55e-30 112.0 COG2220@1|root,COG2220@2|Bacteria,1MUY6@1224|Proteobacteria,42Q5T@68525|delta/epsilon subdivisions,2WKN4@28221|Deltaproteobacteria,2M9PC@213115|Desulfovibrionales 28221|Deltaproteobacteria S Belongs to the UPF0173 family - - - - - - - - - - - - Lactamase_B_2,Lactamase_B_3 k59_914925_2 330214.NIDE4314 2.9e-47 161.0 COG1899@1|root,COG1899@2|Bacteria 2|Bacteria O peptidyl-lysine modification to peptidyl-hypusine - - - - - - - - - - - - - k59_519233_1 1229909.NSED_09015 4.11e-48 169.0 COG1269@1|root,arCOG04138@2157|Archaea,41SRH@651137|Thaumarchaeota 651137|Thaumarchaeota C Belongs to the V-ATPase 116 kDa subunit family - - - ko:K02123 ko00190,ko01100,map00190,map01100 M00159 - - ko00000,ko00001,ko00002 3.A.2.2,3.A.2.3 - - V_ATPase_I k59_519233_2 1229909.NSED_09030 2.49e-37 132.0 COG2897@1|root,arCOG02019@2157|Archaea,41SXR@651137|Thaumarchaeota 651137|Thaumarchaeota P Rhodanese Homology Domain - - 2.8.1.1,2.8.1.2 ko:K01011 ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122 - R01931,R03105,R03106 RC00214 ko00000,ko00001,ko01000 - - - Rhodanese k59_350504_1 1144307.PMI04_04559 4.46e-50 171.0 2DBBP@1|root,2Z88Z@2|Bacteria,1R3B4@1224|Proteobacteria,2TZAY@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Sulfotransferase family - - - - - - - - - - - - Sulfotransfer_3 k59_350504_2 543632.JOJL01000006_gene9596 1.24e-06 51.6 COG1309@1|root,COG1309@2|Bacteria 2|Bacteria K transcriptional regulator - - - - - - - - - - - - TetR_N k59_1536539_1 1122137.AQXF01000002_gene379 6.85e-19 80.5 COG3791@1|root,COG3791@2|Bacteria 2|Bacteria S Glutathione-dependent formaldehyde-activating - - - - - - - - - - - - GFA k59_1536539_2 1122137.AQXF01000002_gene380 1.73e-92 295.0 COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,2TQK9@28211|Alphaproteobacteria 28211|Alphaproteobacteria L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate uvrA - - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - ABC_tran k59_294056_1 1123037.AUDE01000030_gene3219 2.69e-81 267.0 COG3291@1|root,COG5492@1|root,COG3291@2|Bacteria,COG5492@2|Bacteria,4NDZC@976|Bacteroidetes,1HY1V@117743|Flavobacteriia 976|Bacteroidetes DZ adhesin AidA-related - - - - - - - - - - - - CHU_C,PKD,SprB k59_11480_1 449447.MAE_40810 0.000198 49.3 COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,1G0J3@1117|Cyanobacteria 1117|Cyanobacteria KLT serine threonine protein kinase - - - - - - - - - - - - Pkinase,TPR_16,TPR_19,TPR_2,TPR_6,TPR_8 k59_1592752_1 1229909.NSED_06935 4.06e-32 119.0 COG0157@1|root,arCOG01482@2157|Archaea,41SHI@651137|Thaumarchaeota 651137|Thaumarchaeota H Involved in the catabolism of quinolinic acid (QA) - - 2.4.2.19 ko:K00767 ko00760,ko01100,map00760,map01100 M00115 R03348 RC02877 ko00000,ko00001,ko00002,ko01000 - - - QRPTase_C,QRPTase_N k59_1592752_2 1229909.NSED_06940 1.84e-43 146.0 COG0457@1|root,arCOG03032@2157|Archaea 2157|Archaea T PFAM TPR repeat-containing protein - - - - - - - - - - - - TPR_1,TPR_19,TPR_2,TPR_8 k59_1592752_3 1229909.NSED_06945 2.9e-50 168.0 COG0379@1|root,arCOG04459@2157|Archaea,41S6Y@651137|Thaumarchaeota 651137|Thaumarchaeota H Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate nadA - 2.5.1.72 ko:K03517 ko00760,ko01100,map00760,map01100 M00115 R04292 RC01119 ko00000,ko00001,ko00002,ko01000 - - - NadA k59_406535_1 243365.CV_0620 3.68e-65 201.0 COG0139@1|root,COG0139@2|Bacteria,1MW67@1224|Proteobacteria,2VR9B@28216|Betaproteobacteria,2KR2Y@206351|Neisseriales 206351|Neisseriales E Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP hisI - 3.5.4.19 ko:K01496 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04037 RC01055 ko00000,ko00001,ko00002,ko01000 - - - PRA-CH k59_406535_2 29581.BW37_03419 5.25e-10 57.8 COG0140@1|root,COG0140@2|Bacteria,1MZEE@1224|Proteobacteria,2VUN8@28216|Betaproteobacteria,474KE@75682|Oxalobacteraceae 28216|Betaproteobacteria E phosphoribosyl-ATP diphosphatase activity hisE - 3.6.1.31 ko:K01523 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04035 RC00002 ko00000,ko00001,ko00002,ko01000 - - - PRA-PH k59_1084379_1 90371.CY43_01915 6.83e-40 160.0 2DPZ4@1|root,32UN5@2|Bacteria,1N6B8@1224|Proteobacteria,1SB8F@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_519247_1 1209072.ALBT01000026_gene3680 3.27e-21 90.9 COG1280@1|root,COG1280@2|Bacteria,1MXAI@1224|Proteobacteria,1RPWN@1236|Gammaproteobacteria,1FH69@10|Cellvibrio 1236|Gammaproteobacteria E LysE type translocator - - - - - - - - - - - - LysE k59_519247_2 377629.TERTU_0561 1.96e-16 75.5 COG5331@1|root,COG5331@2|Bacteria,1N7DJ@1224|Proteobacteria,1SCVF@1236|Gammaproteobacteria,2PNY0@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria S MAPEG family - - - - - - - - - - - - MAPEG k59_1705694_1 247633.GP2143_05005 1.94e-70 220.0 COG0300@1|root,COG0300@2|Bacteria,1RAFB@1224|Proteobacteria,1S2HE@1236|Gammaproteobacteria,1J5XJ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Belongs to the short-chain dehydrogenases reductases (SDR) family - - - - - - - - - - - - adh_short k59_463077_1 342610.Patl_2408 3.25e-38 141.0 COG0577@1|root,COG0577@2|Bacteria,1MXFC@1224|Proteobacteria,1RQX0@1236|Gammaproteobacteria,2Q0Y2@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria V COG0577 ABC-type antimicrobial peptide transport system, permease component - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_1254217_1 646529.Desaci_0654 3.28e-12 72.0 COG0642@1|root,COG0642@2|Bacteria,COG2205@2|Bacteria,1TQMV@1239|Firmicutes,247SE@186801|Clostridia,267FA@186807|Peptococcaceae 1239|Firmicutes T PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - GAF,HATPase_c,HisKA,Hpt,PAS_3,PAS_4,PAS_9,Response_reg,SBP_bac_3,dCache_1 k59_1254217_2 545276.KB898725_gene671 3.84e-43 155.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,1WVVT@135613|Chromatiales 135613|Chromatiales T response regulator receiver - - - ko:K02667 ko02020,map02020 M00501 - - ko00000,ko00001,ko00002,ko02022,ko02035 - - - HTH_8,Response_reg,Sigma54_activat k59_745498_1 1348114.OM33_17895 2.49e-07 57.8 COG0840@1|root,COG0840@2|Bacteria,1NS95@1224|Proteobacteria,1SJJS@1236|Gammaproteobacteria,2Q410@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria NT Nitrate and nitrite sensing - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - MCPsignal,NIT k59_1084391_1 378806.STAUR_1739 6.42e-134 417.0 COG0553@1|root,COG0553@2|Bacteria,1MV6M@1224|Proteobacteria,42M5P@68525|delta/epsilon subdivisions,2WIW8@28221|Deltaproteobacteria,2YUB7@29|Myxococcales 28221|Deltaproteobacteria KL Superfamily II DNA RNA helicases, SNF2 family - - - - - - - - - - - - Helicase_C,SNF2_N,SWIM k59_1084393_1 1121921.KB898711_gene2108 5.86e-51 172.0 COG0111@1|root,COG0111@2|Bacteria,1MU5Z@1224|Proteobacteria,1RPEY@1236|Gammaproteobacteria,2PMX5@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria EH D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain serA - 1.1.1.399,1.1.1.95 ko:K00058 ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230 M00020 R01513 RC00031 ko00000,ko00001,ko00002,ko01000,ko04147 - - - 2-Hacid_dh,2-Hacid_dh_C,ACT k59_180591_1 292415.Tbd_2397 7.76e-79 261.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2VI3F@28216|Betaproteobacteria,1KSFJ@119069|Hydrogenophilales 119069|Hydrogenophilales V AcrB/AcrD/AcrF family - - - - - - - - - - - - ACR_tran k59_180592_1 199310.c3108 3.51e-121 348.0 COG3148@1|root,COG3148@2|Bacteria,1N8XY@1224|Proteobacteria,1RS6H@1236|Gammaproteobacteria,3XMFX@561|Escherichia 1236|Gammaproteobacteria S DTW yfiP - - ko:K05812 - - - - ko00000 - - - DTW k59_11524_1 637389.Acaty_c2175 2.09e-44 164.0 COG4548@1|root,COG4548@2|Bacteria,1MVBZ@1224|Proteobacteria,1SMM0@1236|Gammaproteobacteria,2NBR8@225057|Acidithiobacillales 225057|Acidithiobacillales P von Willebrand factor (vWF) type A domain - - - - - - - - - - - - - k59_1084397_1 1117647.M5M_00815 1.71e-124 367.0 COG1883@1|root,COG1883@2|Bacteria,1MV0G@1224|Proteobacteria,1RP3W@1236|Gammaproteobacteria,1J570@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit oadB GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006113,GO:0008150,GO:0008152,GO:0008948,GO:0009987,GO:0015980,GO:0016020,GO:0016829,GO:0016830,GO:0016831,GO:0044237,GO:0044464,GO:0055114,GO:0071944 4.1.1.3 ko:K01572 ko00620,ko01100,map00620,map01100 - R00217 RC00040 ko00000,ko00001,ko01000,ko02000 3.B.1.1.1 - - OAD_beta k59_1367343_1 1353537.TP2_13430 3.7e-86 263.0 COG1611@1|root,COG1611@2|Bacteria,1MU6N@1224|Proteobacteria,2TR90@28211|Alphaproteobacteria,2XNXN@285107|Thioclava 28211|Alphaproteobacteria S Possible lysine decarboxylase - - 3.2.2.10 ko:K06966 ko00230,ko00240,map00230,map00240 - R00182,R00510 RC00063,RC00318 ko00000,ko00001,ko01000 - - - Lysine_decarbox k59_294097_1 1123366.TH3_01125 4.26e-41 142.0 COG0118@1|root,COG0118@2|Bacteria,1MU4X@1224|Proteobacteria,2TTT4@28211|Alphaproteobacteria,2JPEU@204441|Rhodospirillales 204441|Rhodospirillales E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR hisH - - ko:K02501 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04558 RC00010,RC01190,RC01943 ko00000,ko00001,ko00002,ko01000 - - - GATase k59_294097_2 1122137.AQXF01000001_gene3346 3.79e-142 404.0 COG0106@1|root,COG0106@2|Bacteria,1MW6S@1224|Proteobacteria,2TRSG@28211|Alphaproteobacteria 28211|Alphaproteobacteria E 1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase hisA GO:0000105,GO:0000162,GO:0003674,GO:0003824,GO:0003949,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.3.1.16 ko:K01814 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04640 RC00945 ko00000,ko00001,ko00002,ko01000 - - - His_biosynth k59_294097_3 1122137.AQXF01000001_gene3345 4.53e-31 115.0 COG0107@1|root,COG0107@2|Bacteria,1MUS0@1224|Proteobacteria,2TQXD@28211|Alphaproteobacteria 28211|Alphaproteobacteria E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit hisF GO:0000107,GO:0003674,GO:0003824,GO:0016740,GO:0016757,GO:0016763 - ko:K02500 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04558 RC00010,RC01190,RC01943 ko00000,ko00001,ko00002,ko01000 - - - His_biosynth k59_1028985_1 1229909.NSED_05805 2.41e-142 419.0 COG0168@1|root,COG0517@1|root,arCOG00606@2157|Archaea,arCOG04145@2157|Archaea,41SZ8@651137|Thaumarchaeota 651137|Thaumarchaeota P CBS domain - - - ko:K03498 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - - CBS,TrkH k59_68252_1 436308.Nmar_0715 1.18e-53 172.0 COG1310@1|root,arCOG01139@2157|Archaea,41SQ7@651137|Thaumarchaeota 651137|Thaumarchaeota S metal-dependent protease of the PAD1 JAB1 superfamily - - - - - - - - - - - - Prok-JAB k59_689044_1 863365.XHC_0399 3.72e-76 246.0 COG0445@1|root,COG0445@2|Bacteria,1MU6F@1224|Proteobacteria,1RMM1@1236|Gammaproteobacteria,1X36F@135614|Xanthomonadales 135614|Xanthomonadales D NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 gidA GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901363 - ko:K03495 - - R08701 RC00053,RC00209,RC00870 ko00000,ko03016,ko03036 - - - GIDA,GIDA_assoc k59_1367347_1 292564.Cyagr_2852 3.18e-20 92.8 COG0275@1|root,COG0275@2|Bacteria,1G0AR@1117|Cyanobacteria,22SEZ@167375|Cyanobium 1117|Cyanobacteria J Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA rsmH GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0070475,GO:0071424,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.199 ko:K03438 - - - - ko00000,ko01000,ko03009 - - - Methyltransf_5 k59_1367347_2 525245.HMPREF0044_0493 5.29e-20 87.4 COG2001@1|root,COG2001@2|Bacteria,2IHUB@201174|Actinobacteria,4D5QE@85005|Actinomycetales 201174|Actinobacteria K Belongs to the MraZ family mraZ GO:0000976,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031333,GO:0040007,GO:0043254,GO:0043565,GO:0044087,GO:0044212,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051129,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2000142,GO:2000143,GO:2001141 - ko:K03925 - - - - ko00000 - - - MraZ k59_294104_1 298654.FraEuI1c_2734 3.69e-23 95.1 COG5517@1|root,COG5517@2|Bacteria,2GR5G@201174|Actinobacteria,4EVIE@85013|Frankiales 201174|Actinobacteria Q SnoaL-like domain - - - - - - - - - - - - SnoaL_4 k59_294104_2 710685.MycrhN_4630 3.7e-63 203.0 COG1028@1|root,COG1028@2|Bacteria,2GKI2@201174|Actinobacteria,235H3@1762|Mycobacteriaceae 201174|Actinobacteria IQ COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - - - - - - - - - - - adh_short,adh_short_C2 k59_68260_1 265072.Mfla_1710 5.67e-73 231.0 COG4992@1|root,COG4992@2|Bacteria,1MV3C@1224|Proteobacteria,2VHEB@28216|Betaproteobacteria,2KM17@206350|Nitrosomonadales 206350|Nitrosomonadales E PFAM Aminotransferase class-III argD - 2.6.1.11,2.6.1.17 ko:K00821 ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00028,M00845 R02283,R04475 RC00006,RC00062 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 k59_1762433_1 1280948.HY36_16455 1.34e-119 362.0 COG2010@1|root,COG4993@1|root,COG2010@2|Bacteria,COG4993@2|Bacteria,1MUQX@1224|Proteobacteria,2TS2Q@28211|Alphaproteobacteria,43X6D@69657|Hyphomonadaceae 28211|Alphaproteobacteria CG alcohol dehydrogenase - - - - - - - - - - - - Cytochrome_CBB3,PQQ,PQQ_2 k59_1254236_1 864069.MicloDRAFT_00029440 6.98e-145 426.0 COG0166@1|root,COG0166@2|Bacteria,1MUFP@1224|Proteobacteria,2TQKP@28211|Alphaproteobacteria,1JSET@119045|Methylobacteriaceae 28211|Alphaproteobacteria G Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway pgi GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 5.3.1.9 ko:K01810 ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200 M00001,M00004,M00114 R02739,R02740,R03321 RC00376,RC00563 ko00000,ko00001,ko00002,ko01000,ko04147 - - - PGI k59_859230_1 870187.Thini_2085 2.18e-75 230.0 COG0431@1|root,COG0431@2|Bacteria,1RGV1@1224|Proteobacteria,1S2U5@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Flavoprotein - - - - - - - - - - - - FMN_red k59_519270_1 551275.KB899545_gene2982 4.33e-121 374.0 COG0243@1|root,COG0243@2|Bacteria,1NS3T@1224|Proteobacteria,2TQYD@28211|Alphaproteobacteria,43W9I@69657|Hyphomonadaceae 28211|Alphaproteobacteria C Molybdopterin oxidoreductase Fe4S4 domain nasA - - ko:K00372 ko00910,ko01120,map00910,map01120 M00531 R00798,R01106 RC02812 ko00000,ko00001,ko00002,ko01000 - - - Fer2_BFD,Molybdop_Fe4S4,Molybdopterin,Molydop_binding k59_859238_1 203122.Sde_3676 5.11e-98 309.0 COG1109@1|root,COG1109@2|Bacteria,1MUA5@1224|Proteobacteria,1RMU8@1236|Gammaproteobacteria,46404@72275|Alteromonadaceae 1236|Gammaproteobacteria G Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II algC GO:0003674,GO:0003824,GO:0004615,GO:0005975,GO:0008150,GO:0008152,GO:0016853,GO:0016866,GO:0016868,GO:0044238,GO:0071704 5.4.2.2,5.4.2.8 ko:K01840,ko:K15778 ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130 M00114 R00959,R01057,R01818,R08639 RC00408 ko00000,ko00001,ko00002,ko01000 - - - PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV k59_350589_1 1038859.AXAU01000026_gene2330 1.94e-138 408.0 COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria,2TT1G@28211|Alphaproteobacteria,3JQQ7@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria E Bacterial extracellular solute-binding proteins, family 5 Middle - - - ko:K02035 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - SBP_bac_5 k59_802419_1 929558.SMGD1_2555 2.26e-13 72.0 294Z4@1|root,2ZSC0@2|Bacteria,1RFNP@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_802419_2 1120968.AUBX01000015_gene3533 6.05e-69 214.0 28NUB@1|root,2ZBSR@2|Bacteria,4NM56@976|Bacteroidetes,47TSC@768503|Cytophagia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_802419_3 1219045.BV98_001627 1.25e-08 54.3 COG2941@1|root,COG2941@2|Bacteria,1RAK4@1224|Proteobacteria,2U85I@28211|Alphaproteobacteria,2K46W@204457|Sphingomonadales 204457|Sphingomonadales H Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol coq7 - - ko:K06134 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00128 R04984,R08775 RC01254 ko00000,ko00001,ko00002,ko01000 - - - COQ7 k59_124430_1 1122137.AQXF01000002_gene539 1.18e-229 649.0 COG0046@1|root,COG0046@2|Bacteria,1MYN4@1224|Proteobacteria,2TRGM@28211|Alphaproteobacteria 28211|Alphaproteobacteria F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL purL - 6.3.5.3 ko:K01952 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04463 RC00010,RC01160 ko00000,ko00001,ko00002,ko01000 - - - AIRS,AIRS_C k59_1705732_1 1128912.GMES_2203 2.76e-36 135.0 COG1726@1|root,COG1726@2|Bacteria,1MU36@1224|Proteobacteria,1RPU1@1236|Gammaproteobacteria,464YM@72275|Alteromonadaceae 1236|Gammaproteobacteria C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol nqrA GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0006810,GO:0006811,GO:0006812,GO:0006814,GO:0008137,GO:0008150,GO:0008152,GO:0015672,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0030001,GO:0030964,GO:0032991,GO:0044425,GO:0050136,GO:0051179,GO:0051234,GO:0055114,GO:0098796,GO:1902494 1.6.5.8 ko:K00346 - - - - ko00000,ko01000 - - - NQRA,NQRA_SLBB k59_1705732_2 1131553.JIBI01000051_gene966 1.96e-25 104.0 COG4658@1|root,COG4658@2|Bacteria,1MVY6@1224|Proteobacteria,2WBWD@28216|Betaproteobacteria,373ZW@32003|Nitrosomonadales 28216|Betaproteobacteria C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol nqrB - 1.6.5.8 ko:K00347 - - - - ko00000,ko01000 - - - NQR2_RnfD_RnfE k59_68277_2 1382230.ASAP_0153 7.55e-49 160.0 COG0295@1|root,COG0295@2|Bacteria,1MY2R@1224|Proteobacteria,2U9FW@28211|Alphaproteobacteria,2JSQC@204441|Rhodospirillales 204441|Rhodospirillales F This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis - - 3.5.4.5 ko:K01489 ko00240,ko00983,ko01100,map00240,map00983,map01100 - R01878,R02485,R08221 RC00074,RC00514 ko00000,ko00001,ko01000 - - - dCMP_cyt_deam_1,dCMP_cyt_deam_2 k59_68277_3 550540.Fbal_2856 2.82e-14 72.0 COG0213@1|root,COG0213@2|Bacteria,1MV3H@1224|Proteobacteria,1RPTG@1236|Gammaproteobacteria 1236|Gammaproteobacteria F The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis deoA GO:0003674,GO:0003824,GO:0004645,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006213,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009032,GO:0009116,GO:0009987,GO:0016740,GO:0016757,GO:0016758,GO:0016763,GO:0033554,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0055086,GO:0071704,GO:0072527,GO:1901135,GO:1901360,GO:1901564,GO:1901657 2.4.2.4 ko:K00758 ko00240,ko00983,ko01100,ko05219,map00240,map00983,map01100,map05219 - R01570,R02484,R08222,R08230 RC00063 ko00000,ko00001,ko01000 - - iB21_1397.B21_04224,iEC042_1314.EC042_4879,iECBD_1354.ECBD_3638,iECB_1328.ECB_04258,iECD_1391.ECD_04258,iECH74115_1262.ECH74115_5897,iECIAI1_1343.ECIAI1_4605,iECIAI39_1322.ECIAI39_4914,iECSE_1348.ECSE_4657,iECSP_1301.ECSP_5465,iECUMN_1333.ECUMN_5006,iECW_1372.ECW_m4744,iEKO11_1354.EKO11_3932,iETEC_1333.ETEC_4738,iEcE24377_1341.EcE24377A_4981,iEcSMS35_1347.EcSMS35_4931,iEcolC_1368.EcolC_3674,iG2583_1286.G2583_5242,iSSON_1240.SSON_4533,iSbBS512_1146.SbBS512_E4929,iUMNK88_1353.UMNK88_5301,iWFL_1372.ECW_m4744,iYL1228.KPN_04838,iZ_1308.Z5984,ic_1306.c5466 Glycos_trans_3N,Glycos_transf_3,PYNP_C k59_971035_1 869210.Marky_1265 1.72e-15 72.4 COG1853@1|root,COG1853@2|Bacteria,1WKCR@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus S COGs COG1853 Conserved protein domain typically associated with flavoprotein oxygenase DIM6 NTAB family - - 1.5.1.36 ko:K00484 ko00350,ko00740,ko01100,ko01120,ko01220,map00350,map00740,map01100,map01120,map01220 - R02698,R03299,R05705,R09748,R09750 RC00046,RC00126 ko00000,ko00001,ko01000 - - - Flavin_Reduct k59_971035_2 457398.HMPREF0326_01701 4.04e-28 117.0 COG2379@1|root,COG2379@2|Bacteria,1MVIK@1224|Proteobacteria,42Q1H@68525|delta/epsilon subdivisions,2WK7W@28221|Deltaproteobacteria,2M8T3@213115|Desulfovibrionales 28221|Deltaproteobacteria G pfam mofrl Glyctk - 2.7.1.165 ko:K11529 ko00030,ko00260,ko00561,ko00630,ko00680,ko01100,ko01120,ko01130,ko01200,map00030,map00260,map00561,map00630,map00680,map01100,map01120,map01130,map01200 M00346 R08572 RC00002,RC00428 ko00000,ko00001,ko00002,ko01000 - - - DUF4147,MOFRL k59_1084421_1 377629.TERTU_2522 2.85e-125 385.0 COG0567@1|root,COG0567@2|Bacteria,1MVBF@1224|Proteobacteria,1RN8K@1236|Gammaproteobacteria,2PMKW@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria C 2-oxoglutarate dehydrogenase N-terminus sucA GO:0003674,GO:0003824,GO:0004591,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016491,GO:0016624,GO:0016903,GO:0016999,GO:0017144,GO:0019752,GO:0032991,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045239,GO:0045240,GO:0045252,GO:0045333,GO:0055114,GO:0071704,GO:0072350,GO:1902494,GO:1990204,GO:1990234 1.2.4.2 ko:K00164 ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00032 R00621,R01933,R01940,R03316,R08549 RC00004,RC00027,RC00627,RC02743,RC02833,RC02883 br01601,ko00000,ko00001,ko00002,ko01000 - - - 2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr k59_11569_1 1124780.ANNU01000013_gene3775 5.35e-77 249.0 COG0668@1|root,COG0668@2|Bacteria,4NHU7@976|Bacteroidetes,47JMR@768503|Cytophagia 976|Bacteroidetes M Mechanosensitive ion channel - - - ko:K16052 - - - - ko00000,ko02000 1.A.23.4 - - MS_channel k59_971978_2 1249627.D779_2392 8.91e-09 54.7 2EH5A@1|root,33AX7@2|Bacteria,1NK4I@1224|Proteobacteria,1SHSP@1236|Gammaproteobacteria,1WZN6@135613|Chromatiales 135613|Chromatiales - - - - - - - - - - - - - - - k59_1091974_1 1122201.AUAZ01000005_gene506 1.12e-26 110.0 COG1704@1|root,COG1704@2|Bacteria,1RDUH@1224|Proteobacteria,1S455@1236|Gammaproteobacteria 1236|Gammaproteobacteria S E3 Ubiquitin ligase - - - - - - - - - - - - GIDE k59_1600525_1 1123267.JONN01000001_gene719 3.7e-35 127.0 COG1695@1|root,COG1695@2|Bacteria,1RHSE@1224|Proteobacteria,2U1HF@28211|Alphaproteobacteria,2K4SR@204457|Sphingomonadales 204457|Sphingomonadales K transcriptional - - - - - - - - - - - - PadR k59_1600525_2 1380391.JIAS01000017_gene695 2.32e-22 89.0 COG3553@1|root,COG3553@2|Bacteria,1N757@1224|Proteobacteria,2UFEV@28211|Alphaproteobacteria 28211|Alphaproteobacteria K Protein conserved in bacteria - - - ko:K09956 - - - - ko00000 - - - DUF2218 k59_414014_1 1101192.KB910516_gene209 0.000378 44.3 COG1506@1|root,COG1506@2|Bacteria,1MUJ3@1224|Proteobacteria,2TUZZ@28211|Alphaproteobacteria,1JUAH@119045|Methylobacteriaceae 28211|Alphaproteobacteria E peptidase S9 prolyl oligopeptidase active site domain protein - - 3.4.19.1 ko:K01303 - - - - ko00000,ko01000,ko01002 - - - PD40,Peptidase_S9 k59_414014_2 506534.Rhein_1143 4.55e-19 88.2 COG0845@1|root,COG0845@2|Bacteria,1MV1T@1224|Proteobacteria,1RQTS@1236|Gammaproteobacteria,1X0Z5@135613|Chromatiales 135613|Chromatiales M HlyD family secretion protein - - - - - - - - - - - - HlyD_3 k59_414019_1 1078020.KEK_02491 3.18e-09 60.5 COG1024@1|root,COG1024@2|Bacteria,2GJ7Z@201174|Actinobacteria,234IG@1762|Mycobacteriaceae 201174|Actinobacteria I enoyl-CoA hydratase isomerase family - - 5.3.3.18 ko:K15866 ko00360,ko01120,map00360,map01120 - R09837,R09839 RC00004,RC00326,RC02689,RC03003 ko00000,ko00001,ko01000 - - - ECH_1 k59_470567_1 1089549.AZUQ01000001_gene2829 3.96e-35 136.0 COG4638@1|root,COG4638@2|Bacteria,2GKJY@201174|Actinobacteria,4F08Y@85014|Glycomycetales 201174|Actinobacteria P Ring hydroxylating alpha subunit (catalytic domain) - - 1.14.12.25 ko:K10619 ko00622,ko01120,ko01220,map00622,map01120,map01220 M00539 R05247 RC00267 br01602,ko00000,ko00001,ko00002,ko01000 - - - Rieske,Ring_hydroxyl_A k59_1600536_1 1122137.AQXF01000002_gene420 1.84e-167 481.0 COG4108@1|root,COG4108@2|Bacteria,1MU7X@1224|Proteobacteria,2TRP5@28211|Alphaproteobacteria 28211|Alphaproteobacteria J Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP prfC - - ko:K02837 - - - - ko00000,ko03012 - - - GTP_EFTU,GTP_EFTU_D2,RF3_C k59_1600536_2 1122137.AQXF01000002_gene421 3.34e-21 90.9 COG1073@1|root,COG1073@2|Bacteria 2|Bacteria S thiolester hydrolase activity - - 3.1.1.24,3.1.1.85 ko:K01055,ko:K02170 ko00362,ko00780,ko01100,ko01120,ko01220,map00362,map00780,map01100,map01120,map01220 M00568,M00572 R02991,R09725 RC00460,RC00461,RC00825 ko00000,ko00001,ko00002,ko01000 - - - Abhydrolase_1,Abhydrolase_6,Hydrolase_4 k59_358326_1 357808.RoseRS_2905 5.87e-127 407.0 COG0236@1|root,COG0304@1|root,COG1028@1|root,COG3321@1|root,COG0236@2|Bacteria,COG0304@2|Bacteria,COG1028@2|Bacteria,COG3321@2|Bacteria,2G68I@200795|Chloroflexi,3765Y@32061|Chloroflexia 32061|Chloroflexia IQ PFAM short-chain dehydrogenase reductase SDR - - - ko:K15314 ko01059,ko01130,map01059,map01130 M00824,M00825 R11435 - ko00000,ko00001,ko00002,ko01008 - - - Acyl_transf_1,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,PS-DH,ketoacyl-synt k59_301974_1 203122.Sde_3629 3.55e-42 154.0 COG0643@1|root,COG0784@1|root,COG2198@1|root,COG3115@1|root,COG0643@2|Bacteria,COG0784@2|Bacteria,COG2198@2|Bacteria,COG3115@2|Bacteria,1MUAG@1224|Proteobacteria,1RMS6@1236|Gammaproteobacteria,4650G@72275|Alteromonadaceae 1236|Gammaproteobacteria T COG0643 Chemotaxis protein histidine kinase and related kinases chpA - - ko:K02487,ko:K06596 ko02020,ko02025,map02020,map02025 M00507 - - ko00000,ko00001,ko00002,ko01001,ko02022,ko02035 - - - CheW,H-kinase_dim,HATPase_c,Hpt,Response_reg k59_867017_1 1118054.CAGW01000023_gene4089 3.88e-79 251.0 COG2021@1|root,COG2021@2|Bacteria,1TQSV@1239|Firmicutes,4HBNC@91061|Bacilli,26S6D@186822|Paenibacillaceae 91061|Bacilli E Belongs to the AB hydrolase superfamily. MetX family metXA GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004414,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008374,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009086,GO:0009092,GO:0009987,GO:0016053,GO:0016407,GO:0016413,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.3.1.31 ko:K00641 ko00270,ko01100,ko01130,map00270,map01100,map01130 - R01776 RC00004,RC00041 ko00000,ko00001,ko01000 - - - Abhydrolase_1 k59_1713406_1 570952.ATVH01000011_gene652 9.35e-94 291.0 COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,2TR4Q@28211|Alphaproteobacteria,2JQMJ@204441|Rhodospirillales 204441|Rhodospirillales S Tripartite tricarboxylate transporter TctA family - - - ko:K07793 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.80.1 - - TctA k59_76221_1 1415778.JQMM01000001_gene52 3.01e-77 253.0 COG3127@1|root,COG3127@2|Bacteria,1MU9R@1224|Proteobacteria,1RM8Y@1236|Gammaproteobacteria,1J4N8@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria Q ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component ybbP GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX k59_301978_1 1042209.HK44_021600 8.69e-82 253.0 COG3335@1|root,COG3335@2|Bacteria,1MW7X@1224|Proteobacteria,1RRMU@1236|Gammaproteobacteria,1YU3Y@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria L Endonuclease DDE - - - - - - - - - - - - DDE_3,HTH_23,HTH_28,HTH_32 k59_753049_1 196367.JNFG01000025_gene8277 1.72e-24 102.0 COG0275@1|root,COG0275@2|Bacteria,1MUT4@1224|Proteobacteria,2VIYT@28216|Betaproteobacteria,1K2HM@119060|Burkholderiaceae 28216|Betaproteobacteria J Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA rsmH - 2.1.1.199 ko:K03438 - - - - ko00000,ko01000,ko03009 - - - Methyltransf_5 k59_1713423_1 1229909.NSED_08765 5.61e-47 161.0 COG0640@1|root,arCOG03067@2157|Archaea 2157|Archaea K transcriptional regulators - - - - - - - - - - - - HTH_20 k59_1205157_1 187272.Mlg_1692 4.38e-54 185.0 COG2027@1|root,COG2027@2|Bacteria,1MW40@1224|Proteobacteria,1RP8V@1236|Gammaproteobacteria,1WWVE@135613|Chromatiales 135613|Chromatiales M PFAM Peptidase S13, D-Ala-D-Ala carboxypeptidase C - - 3.4.16.4 ko:K07259 ko00550,map00550 - - - ko00000,ko00001,ko01000,ko01002,ko01011 - - - Peptidase_S13 k59_1318542_1 316407.85677010 4.35e-261 721.0 COG0433@1|root,COG0433@2|Bacteria,1MU59@1224|Proteobacteria,1RPYD@1236|Gammaproteobacteria,3XP0R@561|Escherichia 1236|Gammaproteobacteria S Type IV secretion-system coupling protein DNA-binding domain yjgR - - ko:K06915 - - - - ko00000 - - - DUF853 k59_1544392_2 436308.Nmar_1224 1.65e-46 151.0 arCOG07192@1|root,arCOG07192@2157|Archaea,41SVA@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1544392_3 436308.Nmar_1225 6.8e-33 120.0 COG0109@1|root,arCOG00479@2157|Archaea,41SDQ@651137|Thaumarchaeota 651137|Thaumarchaeota H Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group - - 2.5.1.141 ko:K02257 ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714 M00154 R07411 RC01786 ko00000,ko00001,ko00002,ko01000,ko01006,ko03029 - - - UbiA k59_922748_1 1306406.ASHX01000002_gene4811 2.28e-08 58.2 COG0154@1|root,COG0154@2|Bacteria,2GKPZ@201174|Actinobacteria 201174|Actinobacteria J Belongs to the amidase family - - - - - - - - - - - - Amidase k59_188605_1 398579.Spea_1966 2.69e-19 90.9 COG3249@1|root,COG3249@2|Bacteria,1N0PD@1224|Proteobacteria,1S9C4@1236|Gammaproteobacteria,2Q8W3@267890|Shewanellaceae 1236|Gammaproteobacteria S Uncharacterized protein conserved in bacteria (DUF2066) VV2512 - - ko:K09938 - - - - ko00000 - - - DUF2066 k59_1430766_1 702113.PP1Y_AT24673 9.24e-43 143.0 COG0440@1|root,COG0440@2|Bacteria,1RAGN@1224|Proteobacteria,2U5CW@28211|Alphaproteobacteria,2K12R@204457|Sphingomonadales 204457|Sphingomonadales E acetolactate synthase ilvH - 2.2.1.6 ko:K01653 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - ACT,ACT_5,ALS_ss_C k59_1430766_2 983920.Y88_0945 3.81e-28 109.0 COG0059@1|root,COG0059@2|Bacteria,1MV7M@1224|Proteobacteria,2TRXI@28211|Alphaproteobacteria,2JZWR@204457|Sphingomonadales 204457|Sphingomonadales EH Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate ilvC - 1.1.1.86 ko:K00053 ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R03051,R04439,R04440,R05068,R05069,R05071 RC00726,RC00836,RC00837,RC01726 ko00000,ko00001,ko00002,ko01000 - - - IlvC,IlvN k59_1770052_1 1047013.AQSP01000097_gene1961 3.62e-25 102.0 COG4122@1|root,COG4122@2|Bacteria,2NPV6@2323|unclassified Bacteria 2|Bacteria S Methyltransferase domain mdmC - - - - - - - - - - - Methyltransf_24,Methyltransf_3 k59_1770052_2 1095769.CAHF01000005_gene1636 9.01e-06 49.3 2DKFZ@1|root,309D6@2|Bacteria,1QZK6@1224|Proteobacteria,2WHMG@28216|Betaproteobacteria,476NY@75682|Oxalobacteraceae 28216|Betaproteobacteria S Domain of unknown function (DUF4382) - - - - - - - - - - - - DUF4382 k59_244509_1 1122137.AQXF01000003_gene2475 1.48e-47 165.0 COG1473@1|root,COG1473@2|Bacteria,1MUIV@1224|Proteobacteria,2TR5B@28211|Alphaproteobacteria 28211|Alphaproteobacteria S amidohydrolase - - - - - - - - - - - - M20_dimer,Peptidase_M20 k59_470616_1 381666.PHG289 2.38e-55 195.0 COG0419@1|root,COG0419@2|Bacteria,1R4Z9@1224|Proteobacteria,2VMIM@28216|Betaproteobacteria,1K4T1@119060|Burkholderiaceae 28216|Betaproteobacteria L ATPase involved in DNA repair - - - ko:K03546 - - - - ko00000,ko03400 - - - - k59_1205165_1 1242864.D187_006574 1.15e-05 50.4 COG0811@1|root,COG0811@2|Bacteria,1NCWW@1224|Proteobacteria,42PKF@68525|delta/epsilon subdivisions,2WNQ4@28221|Deltaproteobacteria 28221|Deltaproteobacteria U MotA TolQ ExbB proton channel aglX - - ko:K03562 ko01120,map01120 - - - ko00000,ko02000 1.A.30.2.2 - - MotA_ExbB k59_1205165_2 2002.JOEQ01000006_gene1483 2.82e-26 114.0 COG0260@1|root,COG0260@2|Bacteria,2GJRB@201174|Actinobacteria,4EHZN@85012|Streptosporangiales 201174|Actinobacteria E Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides pepA GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 3.4.11.1 ko:K01255 ko00480,ko01100,map00480,map01100 - R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 - - - Peptidase_M17,Peptidase_M17_N k59_1092025_1 296591.Bpro_4740 1.26e-23 91.3 2E7PS@1|root,3325B@2|Bacteria,1PVAH@1224|Proteobacteria,2VVUK@28216|Betaproteobacteria 28216|Betaproteobacteria S Evidence 4 Homologs of previously reported genes of - - - - - - - - - - - - - k59_1092025_2 656024.FsymDg_4480 4.54e-21 94.4 COG0166@1|root,COG0166@2|Bacteria,2GJG0@201174|Actinobacteria,4ETZY@85013|Frankiales 201174|Actinobacteria G Belongs to the GPI family pgi - 5.3.1.9 ko:K01810 ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200 M00001,M00004,M00114 R02739,R02740,R03321 RC00376,RC00563 ko00000,ko00001,ko00002,ko01000,ko04147 - - - PGI k59_1544406_1 1110697.NCAST_36_00010 2.1e-61 195.0 29CZA@1|root,2ZZXB@2|Bacteria,2HH6P@201174|Actinobacteria,4FTY7@85025|Nocardiaceae 201174|Actinobacteria - - - - - - - - - - - - - - - k59_696599_1 765912.Thimo_1395 1.04e-30 111.0 COG2920@1|root,COG2920@2|Bacteria,1NDX4@1224|Proteobacteria,1SGA8@1236|Gammaproteobacteria,1X1XV@135613|Chromatiales 135613|Chromatiales H part of a sulfur-relay system - - - ko:K11179 ko04122,map04122 - - - ko00000,ko00001,ko01000,ko03016 - - - DsrC k59_696599_2 768671.ThimaDRAFT_0819 1.19e-85 261.0 COG0583@1|root,COG0583@2|Bacteria,1MXXA@1224|Proteobacteria,1RREE@1236|Gammaproteobacteria,1WWMU@135613|Chromatiales 135613|Chromatiales K LysR substrate binding domain - - - - - - - - - - - - HTH_1,LysR_substrate k59_526508_1 1041146.ATZB01000006_gene2285 4.91e-10 59.7 COG2128@1|root,COG2128@2|Bacteria,1NDTM@1224|Proteobacteria,2U4SU@28211|Alphaproteobacteria,4BAV4@82115|Rhizobiaceae 28211|Alphaproteobacteria S Carboxymuconolactone decarboxylase family - - - - - - - - - - - - CMD k59_188621_1 525897.Dbac_1840 3.27e-34 134.0 COG1178@1|root,COG1178@2|Bacteria,1MWEV@1224|Proteobacteria,42TI5@68525|delta/epsilon subdivisions,2WQR8@28221|Deltaproteobacteria,2MG9C@213115|Desulfovibrionales 28221|Deltaproteobacteria P PFAM binding-protein-dependent transport systems inner membrane component - - - ko:K02011 ko02010,map02010 M00190 - - ko00000,ko00001,ko00002,ko02000 3.A.1.10 - - BPD_transp_1 k59_414084_1 1096930.L284_10590 6.1e-79 243.0 COG2896@1|root,COG2896@2|Bacteria,1MW3W@1224|Proteobacteria,2TQQP@28211|Alphaproteobacteria,2K041@204457|Sphingomonadales 204457|Sphingomonadales H Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate moaA - 4.1.99.22 ko:K03639 ko00790,ko01100,ko04122,map00790,map01100,map04122 - R09394 RC03420 ko00000,ko00001,ko01000 - - - Fer4_12,Mob_synth_C,Radical_SAM k59_414084_2 1219035.NT2_01_04270 2.18e-06 47.4 COG1977@1|root,COG1977@2|Bacteria,1NKJE@1224|Proteobacteria,2UKXA@28211|Alphaproteobacteria,2K7QU@204457|Sphingomonadales 204457|Sphingomonadales H Molybdopterin converting factor, small subunit - - - ko:K03636 ko04122,map04122 - - - ko00000,ko00001 - - - ThiS k59_1430796_1 1380387.JADM01000001_gene420 0.000975 42.4 COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,1RMQ4@1236|Gammaproteobacteria,1XI7A@135619|Oceanospirillales 135619|Oceanospirillales IQ COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II - - - ko:K00666 - - - - ko00000,ko01000,ko01004 - - - AMP-binding,AMP-binding_C k59_1430796_2 1207063.P24_13378 2.25e-52 179.0 COG1574@1|root,COG1574@2|Bacteria,1MWP2@1224|Proteobacteria,2TXAW@28211|Alphaproteobacteria,2JRIA@204441|Rhodospirillales 204441|Rhodospirillales S Amidohydrolase family - - - - - - - - - - - - Amidohydro_3 k59_1148369_1 1088721.NSU_4890 8.86e-94 292.0 COG3563@1|root,COG3563@2|Bacteria,1MW0T@1224|Proteobacteria,2TTAJ@28211|Alphaproteobacteria,2K13D@204457|Sphingomonadales 204457|Sphingomonadales M Capsule polysaccharide - - - ko:K07266 - - - - ko00000 - - - Capsule_synth k59_696613_1 1174684.EBMC1_02890 7.8e-47 160.0 COG3384@1|root,COG3384@2|Bacteria,1MXJZ@1224|Proteobacteria,2TRJT@28211|Alphaproteobacteria,2K0K2@204457|Sphingomonadales 204457|Sphingomonadales S dioxygenase - - - ko:K15777 ko00965,map00965 - R08836 RC00387 ko00000,ko00001,ko01000 - - - LigB k59_470649_1 1088721.NSU_1173 9.58e-47 165.0 COG0248@1|root,COG0248@2|Bacteria,1MV35@1224|Proteobacteria,2TR1W@28211|Alphaproteobacteria,2JZYK@204457|Sphingomonadales 204457|Sphingomonadales FP exopolyphosphatase - - 3.6.1.11,3.6.1.40 ko:K01524 ko00230,map00230 - R03409 RC00002 ko00000,ko00001,ko01000 - - - Ppx-GppA k59_358391_1 944435.AXAJ01000016_gene2555 2.1e-81 261.0 COG1018@1|root,COG1018@2|Bacteria,1MY2Q@1224|Proteobacteria,2VMHR@28216|Betaproteobacteria,1K0JY@119060|Burkholderiaceae 28216|Betaproteobacteria C oxidoreductase FAD NAD(P)-binding domain protein - - - ko:K11933,ko:K21832 - - - - ko00000,ko01000 - - - FAD_binding_6,Fer2,NAD_binding_1 k59_1713476_1 1287488.HMPREF0671_08340 2.77e-27 114.0 COG1554@1|root,COG1554@2|Bacteria,4NEWW@976|Bacteroidetes,2FMF9@200643|Bacteroidia 976|Bacteroidetes G COG NOG04001 non supervised orthologous group - - 3.2.1.51 ko:K15923 ko00511,map00511 - - - ko00000,ko00001,ko01000 - GH95 - Glyco_hyd_65N_2 k59_302047_1 1122137.AQXF01000001_gene3218 1.48e-23 100.0 COG1199@1|root,COG1199@2|Bacteria,1MVCU@1224|Proteobacteria,2TUKS@28211|Alphaproteobacteria 28211|Alphaproteobacteria KL helicase dinG - 3.6.4.12 ko:K03722 - - - - ko00000,ko01000,ko03400 - - - Helicase_C_2 k59_302047_2 1122137.AQXF01000001_gene3219 2.92e-94 289.0 COG1384@1|root,COG1384@2|Bacteria,1MV32@1224|Proteobacteria,2TQYH@28211|Alphaproteobacteria 28211|Alphaproteobacteria J Belongs to the class-I aminoacyl-tRNA synthetase family lysS - 6.1.1.6 ko:K04566 ko00970,map00970 M00360 R03658 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_1f k59_1375208_2 1123073.KB899241_gene2690 3.63e-49 170.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RRXX@1236|Gammaproteobacteria,1X5SE@135614|Xanthomonadales 135614|Xanthomonadales T Sigma-54 interaction domain - - - - - - - - - - - - HTH_8,Response_reg,Sigma54_activat k59_583561_1 999541.bgla_2g29490 2.87e-18 87.8 COG3209@1|root,COG3210@1|root,COG3209@2|Bacteria,COG3210@2|Bacteria,1MX2K@1224|Proteobacteria,2VI40@28216|Betaproteobacteria,1K0FX@119060|Burkholderiaceae 28216|Betaproteobacteria U TIGRFAM filamentous haemagglutinin family outer membrane protein - - - ko:K15125 ko05133,map05133 - - - ko00000,ko00001,ko00536 - - - ESPR,Fil_haemagg,Fil_haemagg_2,Haemagg_act,PT-VENN k59_583561_3 266779.Meso_3443 3.35e-29 113.0 COG0806@1|root,COG0806@2|Bacteria,1MWQR@1224|Proteobacteria,2U9UT@28211|Alphaproteobacteria,43JS1@69277|Phyllobacteriaceae 28211|Alphaproteobacteria J An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes rimM - - ko:K02860 - - - - ko00000,ko03009 - - - PRC,RimM k59_922791_1 1274.HX89_00300 1.44e-76 239.0 COG3335@1|root,COG3335@2|Bacteria,2GJQI@201174|Actinobacteria 201174|Actinobacteria L Transposase - - - - - - - - - - - - DDE_3,HTH_28,HTH_29,HTH_32 k59_414116_1 1168065.DOK_02471 1.21e-76 243.0 COG0364@1|root,COG0364@2|Bacteria,1MUN0@1224|Proteobacteria,1RN76@1236|Gammaproteobacteria,1J4GP@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria G Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone zwf GO:0003674,GO:0003824,GO:0004345,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007267,GO:0008150,GO:0008152,GO:0009117,GO:0009372,GO:0009987,GO:0010699,GO:0016491,GO:0016614,GO:0016616,GO:0019318,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0023052,GO:0034641,GO:0042802,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0044764,GO:0046483,GO:0046496,GO:0051156,GO:0051186,GO:0051704,GO:0055086,GO:0055114,GO:0071704,GO:0072524,GO:1901135,GO:1901360,GO:1901564 1.1.1.363,1.1.1.49 ko:K00036 ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230 M00004,M00006,M00008 R00835,R02736,R10907 RC00001,RC00066 ko00000,ko00001,ko00002,ko01000,ko04147 - - e_coli_core.b1852,iAF1260.b1852,iBWG_1329.BWG_1666,iE2348C_1286.E2348C_1977,iEC042_1314.EC042_2019,iECABU_c1320.ECABU_c21130,iECDH10B_1368.ECDH10B_1993,iECDH1ME8569_1439.ECDH1ME8569_1798,iECED1_1282.ECED1_2057,iECIAI39_1322.ECIAI39_1198,iECNA114_1301.ECNA114_1899,iECO26_1355.ECO26_2690,iECP_1309.ECP_1796,iECSF_1327.ECSF_1710,iECUMN_1333.ECUMN_2149,iECW_1372.ECW_m2026,iEKO11_1354.EKO11_1918,iEcDH1_1363.EcDH1_1789,iEcE24377_1341.EcE24377A_2082,iEcHS_1320.EcHS_A1944,iEcSMS35_1347.EcSMS35_1335,iEcolC_1368.EcolC_1780,iG2583_1286.G2583_2304,iJO1366.b1852,iJR904.b1852,iLF82_1304.LF82_3733,iNRG857_1313.NRG857_09280,iSDY_1059.SDY_1138,iWFL_1372.ECW_m2026,iY75_1357.Y75_RS09725,iYL1228.KPN_02367,ic_1306.c2265 G6PD_C,G6PD_N k59_1318594_2 1122137.AQXF01000005_gene1149 4.33e-291 801.0 COG0312@1|root,COG0312@2|Bacteria,1MUSK@1224|Proteobacteria,2TRSR@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Modulator of DNA gyrase tldD GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - ko:K03568 - - - - ko00000,ko01002 - - - PmbA_TldD k59_922799_1 330214.NIDE2052 1.1e-75 240.0 COG4591@1|root,COG4591@2|Bacteria,3J0EF@40117|Nitrospirae 40117|Nitrospirae M MacB-like periplasmic core domain - - - ko:K09808 ko02010,map02010 M00255 - - ko00000,ko00001,ko00002,ko02000 3.A.1.125 - - FtsX,MacB_PCD k59_188684_1 1122194.AUHU01000002_gene2848 6.81e-43 160.0 COG1196@1|root,COG1196@2|Bacteria,1MUAQ@1224|Proteobacteria,1RNA6@1236|Gammaproteobacteria,4645X@72275|Alteromonadaceae 1236|Gammaproteobacteria D Required for chromosome condensation and partitioning smc - - ko:K03529 - - - - ko00000,ko03036 - - - SMC_N,SMC_hinge k59_302061_1 1458860.A0A088C3E8_9CAUD 3.38e-69 221.0 4QC2G@10239|Viruses,4QV3V@35237|dsDNA viruses no RNA stage,4QPRR@28883|Caudovirales,4QI1T@10662|Myoviridae 10662|Myoviridae S Ribonucleotide reductase, small chain - - - - - - - - - - - - - k59_358421_1 264198.Reut_A2722 7.77e-52 176.0 COG0543@1|root,COG1018@1|root,COG0543@2|Bacteria,COG1018@2|Bacteria,1MV72@1224|Proteobacteria,2VI9K@28216|Betaproteobacteria,1JZMG@119060|Burkholderiaceae 28216|Betaproteobacteria C oxidoreductase FAD NAD(P)-binding domain protein ascD - 1.17.1.1 ko:K00523,ko:K18248 ko00520,ko00627,ko01120,map00520,map00627,map01120 M00637 R00823,R00825,R03391,R03392 RC00192,RC00230 br01602,ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_6,Fer2,NAD_binding_1 k59_1318604_1 2340.JV46_28740 8.13e-46 167.0 COG0013@1|root,COG0013@2|Bacteria,1MU9A@1224|Proteobacteria,1RMWZ@1236|Gammaproteobacteria,1J58G@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain alaS GO:0001130,GO:0001131,GO:0001141,GO:0001217,GO:0002161,GO:0002196,GO:0003674,GO:0003700,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006355,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006450,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009451,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016070,GO:0016597,GO:0016787,GO:0016788,GO:0016874,GO:0016875,GO:0019219,GO:0019222,GO:0019538,GO:0019752,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0042802,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045934,GO:0046483,GO:0046872,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0052689,GO:0060255,GO:0065007,GO:0065008,GO:0071704,GO:0080090,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:0140110,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 6.1.1.7 ko:K01872 ko00970,map00970 M00359,M00360 R03038 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iECABU_c1320.ECABU_c29670,iECED1_1282.ECED1_3146,iEcHS_1320.EcHS_A2833,iJN746.PP_4474 DHHA1,tRNA-synt_2c,tRNA_SAD k59_527622_1 215803.DB30_8352 1.54e-27 104.0 COG0454@1|root,COG0456@2|Bacteria,1NEWG@1224|Proteobacteria,42VG1@68525|delta/epsilon subdivisions,2WRCC@28221|Deltaproteobacteria,2Z0N4@29|Myxococcales 28221|Deltaproteobacteria K Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_1,Acetyltransf_7 k59_641373_1 136273.GY22_02210 1.74e-12 68.9 COG4635@1|root,COG4635@2|Bacteria,2IQCQ@201174|Actinobacteria,1W9SR@1268|Micrococcaceae 201174|Actinobacteria CH Flavodoxin domain - - 1.3.5.3 ko:K00230 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R09489 RC00885 ko00000,ko00001,ko00002,ko01000 - - - Flavodoxin_5 k59_471753_1 99598.Cal7507_0667 1.79e-08 61.2 COG2141@1|root,COG2141@2|Bacteria,1G134@1117|Cyanobacteria,1HQMS@1161|Nostocales 1117|Cyanobacteria C Luciferase-like monooxygenase - - 1.14.14.35,1.14.14.5 ko:K04091,ko:K17228 ko00920,map00920 - R07210,R10203,R10206 RC01779,RC02556,RC03080 ko00000,ko00001,ko01000 - - - Bac_luciferase k59_1431990_1 292415.Tbd_2669 2.15e-44 154.0 COG1073@1|root,COG1073@2|Bacteria,1N1WH@1224|Proteobacteria,2W50B@28216|Betaproteobacteria 28216|Betaproteobacteria S Protein of unknown function (DUF3530) - - - - - - - - - - - - DUF3530 k59_359830_1 558884.JRGM01000180_gene3742 7.94e-26 104.0 2DBB6@1|root,2Z85M@2|Bacteria,1QMDX@1224|Proteobacteria,1RZPX@1236|Gammaproteobacteria,1Y44S@135624|Aeromonadales 135624|Aeromonadales - - - - - - - - - - - - - - - k59_77717_1 626887.J057_11831 6.16e-76 236.0 COG1131@1|root,COG1131@2|Bacteria,1MX56@1224|Proteobacteria,1S0C7@1236|Gammaproteobacteria,466WS@72275|Alteromonadaceae 1236|Gammaproteobacteria V COG1131 ABC-type multidrug transport system, ATPase component pedB - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_77717_2 945543.VIBR0546_06602 7.02e-20 87.0 COG3391@1|root,COG3391@2|Bacteria,1P862@1224|Proteobacteria,1RQZK@1236|Gammaproteobacteria,1XVP4@135623|Vibrionales 135623|Vibrionales S Lactonase, 7-bladed beta-propeller - - - - - - - - - - - - Lactonase k59_923908_1 1178537.BA1_17275 1.5e-23 108.0 COG0028@1|root,COG0028@2|Bacteria,1TQE8@1239|Firmicutes,4HAV1@91061|Bacilli,1ZEGW@1386|Bacillus 91061|Bacilli EH Thiamine pyrophosphate enzyme, central domain - - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_1319670_1 2340.JV46_17970 2.3e-27 109.0 COG2863@1|root,COG2863@2|Bacteria,1R6DK@1224|Proteobacteria,1S1YD@1236|Gammaproteobacteria 1236|Gammaproteobacteria C PFAM Cytochrome C - - - - - - - - - - - - Cytochrom_C k59_641382_1 396588.Tgr7_2048 2.32e-93 286.0 COG0124@1|root,COG0124@2|Bacteria,1MV2K@1224|Proteobacteria,1RPHI@1236|Gammaproteobacteria,1WWGZ@135613|Chromatiales 135613|Chromatiales J PFAM tRNA synthetase class II (G H P and S) hisS - 6.1.1.21 ko:K01892 ko00970,map00970 M00359,M00360 R03655 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,tRNA-synt_His k59_1602060_1 485917.Phep_3210 1.55e-11 72.4 COG0248@1|root,COG0248@2|Bacteria,4NH03@976|Bacteroidetes,1IQTS@117747|Sphingobacteriia 976|Bacteroidetes FP PFAM Ppx GppA phosphatase ppx - 3.6.1.11,3.6.1.40 ko:K01524 ko00230,map00230 - R03409 RC00002 ko00000,ko00001,ko01000 - - - HD,Ppx-GppA k59_1602062_1 330214.NIDE0799 1e-90 277.0 COG0304@1|root,COG0304@2|Bacteria,3J0DH@40117|Nitrospirae 40117|Nitrospirae I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP - - 2.3.1.179 ko:K09458 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119 RC00039,RC02728,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Ketoacyl-synt_C,ketoacyl-synt k59_868495_1 1384056.N787_11025 4.67e-81 257.0 COG0018@1|root,COG0018@2|Bacteria,1MU4J@1224|Proteobacteria,1RPRC@1236|Gammaproteobacteria,1X30N@135614|Xanthomonadales 135614|Xanthomonadales J Catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA argS GO:0003674,GO:0003824,GO:0004812,GO:0004814,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006420,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.19 ko:K01887 ko00970,map00970 M00359,M00360 R03646 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d k59_1262460_1 317619.ANKN01000010_gene2991 6.12e-65 208.0 COG0412@1|root,COG0412@2|Bacteria,1G3JS@1117|Cyanobacteria 1117|Cyanobacteria Q dienelactone hydrolase - - 3.1.1.45 ko:K01061 ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130 - R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222 RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686 ko00000,ko00001,ko01000 - - - DLH k59_1206612_1 1134474.O59_001172 2.97e-174 504.0 COG0366@1|root,COG0366@2|Bacteria,1MVKX@1224|Proteobacteria,1RMXP@1236|Gammaproteobacteria 1236|Gammaproteobacteria G Alpha amylase catalytic ams - 2.4.1.4,3.2.1.1,5.4.99.16 ko:K05341,ko:K05343 ko00500,ko01100,map00500,map01100 - R01557,R01823,R02108,R02112,R11262 RC00028,RC01816 ko00000,ko00001,ko01000 - GH13 - Alpha-amylase,Malt_amylase_C k59_1489675_1 1207076.ALAT01000230_gene658 2.69e-50 178.0 COG0568@1|root,COG0568@2|Bacteria,1MVNJ@1224|Proteobacteria,1RMQI@1236|Gammaproteobacteria,1Z179@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth rpoD GO:0000988,GO:0000990,GO:0003674,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006352,GO:0006355,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0016987,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031326,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043254,GO:0044087,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901576,GO:1903506,GO:2000112,GO:2000142,GO:2001141 - ko:K03086 - - - - ko00000,ko03021 - - - Sigma70_ner,Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4 k59_1319687_1 882082.SaccyDRAFT_0216 1.89e-21 93.6 COG1396@1|root,COG1396@2|Bacteria,2GK1R@201174|Actinobacteria,4DXKX@85010|Pseudonocardiales 201174|Actinobacteria K Helix-turn-helix XRE-family like proteins - - - - - - - - - - - - HTH_3,HTH_31 k59_254178_1 1415778.JQMM01000001_gene365 2.65e-25 104.0 COG5000@1|root,COG5000@2|Bacteria,1NU7E@1224|Proteobacteria,1S01Y@1236|Gammaproteobacteria,1J5XZ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T PAS fold - - - - - - - - - - - - HAMP,HATPase_c,HisKA,PAS,PAS_4 k59_29401_2 330214.NIDE2040 9.46e-79 248.0 COG0147@1|root,COG0147@2|Bacteria,3J0FG@40117|Nitrospirae 40117|Nitrospirae EH Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia trpE - 4.1.3.27 ko:K01657 ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025 M00023 R00985,R00986 RC00010,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 - - - Anth_synt_I_N,Chorismate_bind k59_647645_2 469381.Dpep_2199 3.62e-14 76.3 COG4666@1|root,COG4666@2|Bacteria,3TA8D@508458|Synergistetes 508458|Synergistetes S TRAP transporter, 4TM 12TM fusion protein - - - - - - - - - - - - DctM k59_533369_1 1232410.KI421421_gene3721 6.81e-92 296.0 COG1703@1|root,COG1884@1|root,COG2185@1|root,COG1703@2|Bacteria,COG1884@2|Bacteria,COG2185@2|Bacteria,1MUXX@1224|Proteobacteria,42MVK@68525|delta/epsilon subdivisions,2WKEN@28221|Deltaproteobacteria,43TYG@69541|Desulfuromonadales 28221|Deltaproteobacteria EI Methylmalonyl-CoA mutase icmF - 5.4.99.13 ko:K11942 - - - - ko00000,ko01000 - - - ArgK,B12-binding,MM_CoA_mutase k59_1269008_2 626887.J057_06426 7.26e-19 86.3 COG0697@1|root,COG0697@2|Bacteria,1R46X@1224|Proteobacteria,1RYTA@1236|Gammaproteobacteria,46BKK@72275|Alteromonadaceae 1236|Gammaproteobacteria U EamA-like transporter family - - - - - - - - - - - - EamA k59_1157372_1 686340.Metal_3155 2.47e-50 170.0 2CAM1@1|root,301FE@2|Bacteria,1RJ36@1224|Proteobacteria,1S7TX@1236|Gammaproteobacteria,1XFDM@135618|Methylococcales 135618|Methylococcales S Ceramidase - - - - - - - - - - - - Ceramidase k59_1665664_1 316407.85676306 2.16e-99 300.0 COG0055@1|root,COG0055@2|Bacteria,1MUFU@1224|Proteobacteria,1RN6U@1236|Gammaproteobacteria,3XPEM@561|Escherichia 1236|Gammaproteobacteria F Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits atpD GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0036442,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045261,GO:0045262,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0046961,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 3.6.3.14 ko:K02112 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - e_coli_core.b3732,iAF1260.b3732,iAPECO1_1312.APECO1_2729,iB21_1397.B21_03560,iBWG_1329.BWG_3423,iE2348C_1286.E2348C_4042,iEC042_1314.EC042_4119,iEC55989_1330.EC55989_4207,iECABU_c1320.ECABU_c42160,iECBD_1354.ECBD_4300,iECB_1328.ECB_03616,iECDH10B_1368.ECDH10B_3919,iECDH1ME8569_1439.ECDH1ME8569_3620,iECD_1391.ECD_03616,iECED1_1282.ECED1_4422,iECH74115_1262.ECH74115_5168,iECIAI1_1343.ECIAI1_3916,iECIAI39_1322.ECIAI39_4336,iECNA114_1301.ECNA114_3881,iECO103_1326.ECO103_4426,iECO111_1330.ECO111_4566,iECO26_1355.ECO26_4846,iECOK1_1307.ECOK1_4181,iECP_1309.ECP_3931,iECS88_1305.ECS88_4154,iECSE_1348.ECSE_4022,iECSF_1327.ECSF_3580,iECSP_1301.ECSP_4782,iECUMN_1333.ECUMN_4262,iECW_1372.ECW_m4035,iECs_1301.ECs4674,iEKO11_1354.EKO11_4613,iETEC_1333.ETEC_4023,iEcDH1_1363.EcDH1_4235,iEcE24377_1341.EcE24377A_4247,iEcSMS35_1347.EcSMS35_4100,iEcolC_1368.EcolC_4262,iG2583_1286.G2583_4528,iJO1366.b3732,iJR904.b3732,iLF82_1304.LF82_0194,iNRG857_1313.NRG857_18585,iPC815.YPO4121,iSFV_1184.SFV_3758,iSF_1195.SF3812,iSFxv_1172.SFxv_4154,iSSON_1240.SSON_3887,iS_1188.S3956,iSbBS512_1146.SbBS512_E4189,iUMN146_1321.UM146_18850,iUMNK88_1353.UMNK88_4544,iUTI89_1310.UTI89_C4285,iWFL_1372.ECW_m4035,iY75_1357.Y75_RS18410,iZ_1308.Z5230,ic_1306.c4658 ATP-synt_ab,ATP-synt_ab_N k59_1665664_2 999141.GME_10351 2.75e-08 54.3 COG0224@1|root,COG0224@2|Bacteria,1MU28@1224|Proteobacteria,1RNWJ@1236|Gammaproteobacteria,1XHVC@135619|Oceanospirillales 135619|Oceanospirillales C Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex atpG - - ko:K02115 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt k59_1385289_1 316407.85674719 7.49e-23 96.7 COG1966@1|root,COG1966@2|Bacteria,1MWF9@1224|Proteobacteria,1RMG4@1236|Gammaproteobacteria,3XM2Y@561|Escherichia 1236|Gammaproteobacteria T carbon starvation protein cstA GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0042594,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051716,GO:0071496,GO:0071944 - ko:K06200 - - - - ko00000 - - - CstA,CstA_5TM k59_1385289_2 316407.4062215 1.77e-35 120.0 COG2879@1|root,COG2879@2|Bacteria,1N6TY@1224|Proteobacteria,1S8ZU@1236|Gammaproteobacteria,3XPZM@561|Escherichia 1236|Gammaproteobacteria S Selenoprotein, putative ybdD - - - - - - - - - - - Sel_put k59_478029_1 1168065.DOK_14704 8.3e-124 357.0 COG1305@1|root,COG1305@2|Bacteria,1MWAI@1224|Proteobacteria,1RRMA@1236|Gammaproteobacteria,1J4ZM@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Transglutaminase/protease-like homologues - - - - - - - - - - - - Bact_transglu_N,Transglut_core k59_1555413_1 1449350.OCH239_03875 7.4e-132 382.0 COG3328@1|root,COG3328@2|Bacteria,1MU4P@1224|Proteobacteria,2TUQT@28211|Alphaproteobacteria,4KNY3@93682|Roseivivax 28211|Alphaproteobacteria L Transposase, Mutator family - - - - - - - - - - - - Transposase_mut k59_930079_1 498848.TaqDRAFT_4015 7.94e-41 153.0 COG0109@1|root,COG1612@1|root,COG0109@2|Bacteria,COG1612@2|Bacteria,1WIAB@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus O Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group ctaB GO:0003674,GO:0003824,GO:0004311,GO:0004659,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0015980,GO:0016020,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044464,GO:0045333,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.141 ko:K02257 ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714 M00154 R07411 RC01786 ko00000,ko00001,ko00002,ko01000,ko01006,ko03029 - - - COX15-CtaA,UbiA k59_816896_1 1229909.NSED_05300 5.32e-79 244.0 COG1378@1|root,arCOG02038@2157|Archaea 2157|Archaea K transcriptional - - - - - - - - - - - - Regulator_TrmB,TrmB k59_706793_1 563192.HMPREF0179_02771 2.71e-15 72.8 COG0355@1|root,COG0355@2|Bacteria,1RHE4@1224|Proteobacteria,42TII@68525|delta/epsilon subdivisions,2WPVK@28221|Deltaproteobacteria,2MBW9@213115|Desulfovibrionales 28221|Deltaproteobacteria C Produces ATP from ADP in the presence of a proton gradient across the membrane atpC GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016469,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0045259,GO:0045261,GO:0046034,GO:0046390,GO:0046483,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - ko:K02114 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt_DE,ATP-synt_DE_N k59_706793_2 1519464.HY22_02460 5.77e-206 581.0 COG0055@1|root,COG0055@2|Bacteria,1FDDD@1090|Chlorobi 1090|Chlorobi F Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits atpD - 3.6.3.14 ko:K02112 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - - ATP-synt_ab,ATP-synt_ab_N k59_86566_1 1038860.AXAP01000089_gene3713 3.77e-82 254.0 COG2159@1|root,COG2159@2|Bacteria,1R5PG@1224|Proteobacteria,2U2G9@28211|Alphaproteobacteria,3JWBY@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S Amidohydrolase - - 4.1.1.45 ko:K03392 ko00380,ko01100,map00380,map01100 M00038 R04323 RC00779 ko00000,ko00001,ko00002,ko01000 - - - Amidohydro_2 k59_1157419_1 199310.c3916 1.54e-87 276.0 COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,1RMWA@1236|Gammaproteobacteria,3XNGY@561|Escherichia 1236|Gammaproteobacteria F DEAD-box RNA helicase involved in various cellular processes at low temperature, including ribosome biogenesis, mRNA degradation and translation initiation deaD GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003724,GO:0003725,GO:0003727,GO:0003824,GO:0004004,GO:0004386,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006401,GO:0006417,GO:0006725,GO:0006807,GO:0006950,GO:0006996,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009056,GO:0009057,GO:0009266,GO:0009314,GO:0009409,GO:0009628,GO:0009889,GO:0009891,GO:0009892,GO:0009893,GO:0009894,GO:0009895,GO:0009987,GO:0010468,GO:0010501,GO:0010556,GO:0010557,GO:0010604,GO:0010605,GO:0010608,GO:0010628,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019219,GO:0019222,GO:0019439,GO:0022607,GO:0022613,GO:0022618,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031328,GO:0031329,GO:0031330,GO:0032268,GO:0032270,GO:0033554,GO:0033592,GO:0034248,GO:0034250,GO:0034622,GO:0034641,GO:0034655,GO:0042254,GO:0042255,GO:0042273,GO:0042623,GO:0043170,GO:0043487,GO:0043488,GO:0043489,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0045727,GO:0045934,GO:0046483,GO:0046700,GO:0048255,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051173,GO:0051246,GO:0051247,GO:0051252,GO:0051253,GO:0051716,GO:0060255,GO:0061013,GO:0065003,GO:0065007,GO:0065008,GO:0070035,GO:0070417,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0080090,GO:0090304,GO:0097159,GO:0097617,GO:0140098,GO:1901360,GO:1901361,GO:1901363,GO:1901575,GO:1902369,GO:1902373,GO:1903311,GO:1903312,GO:2000112 3.6.4.13 ko:K05592 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03009,ko03019 - - - DEAD,DEADboxA,DbpA,Helicase_C k59_930097_1 1288494.EBAPG3_27460 2.67e-59 201.0 COG0497@1|root,COG0497@2|Bacteria,1MUNP@1224|Proteobacteria,2VHHA@28216|Betaproteobacteria,372RK@32003|Nitrosomonadales 28216|Betaproteobacteria L May be involved in recombinational repair of damaged DNA recN - - ko:K03631 - - - - ko00000,ko03400 - - - SMC_N k59_877276_1 756067.MicvaDRAFT_4592 7.24e-26 114.0 COG0515@1|root,COG2203@1|root,COG3899@1|root,COG4191@1|root,COG0515@2|Bacteria,COG2203@2|Bacteria,COG3899@2|Bacteria,COG4191@2|Bacteria,1GC5R@1117|Cyanobacteria,1HE5R@1150|Oscillatoriales 1117|Cyanobacteria T SMART Serine threonine-protein kinase domain - - - - - - - - - - - - AAA_16,GAF,HATPase_c,HisKA,Pkinase k59_1555446_1 983545.Glaag_2318 1.06e-57 194.0 COG0477@1|root,COG2814@2|Bacteria,1MVSC@1224|Proteobacteria,1S029@1236|Gammaproteobacteria,465C0@72275|Alteromonadaceae 1236|Gammaproteobacteria EGP Major facilitator superfamily - - - - - - - - - - - - MFS_1 k59_1665701_1 177437.HRM2_36780 2.39e-134 402.0 COG1321@1|root,COG1321@2|Bacteria,1N8WG@1224|Proteobacteria 1224|Proteobacteria K iron dependent repressor - - - - - - - - - - - - - k59_533415_1 1173028.ANKO01000130_gene1867 1.08e-07 53.1 COG2135@1|root,COG2135@2|Bacteria,1G1SA@1117|Cyanobacteria,1HAGW@1150|Oscillatoriales 1117|Cyanobacteria S Belongs to the SOS response-associated peptidase family - - - - - - - - - - - - SRAP k59_533415_2 1049564.TevJSym_ac01640 3.35e-57 186.0 COG0842@1|root,COG0842@2|Bacteria,1MUH1@1224|Proteobacteria,1RP0Z@1236|Gammaproteobacteria,1J4RI@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria V COG0842 ABC-type multidrug transport system, permease component yadH GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane k59_196599_1 697282.Mettu_2585 3.2e-11 70.1 COG0635@1|root,COG0635@2|Bacteria,1MV1I@1224|Proteobacteria,1RN1Y@1236|Gammaproteobacteria,1XDY2@135618|Methylococcales 135618|Methylococcales H Belongs to the anaerobic coproporphyrinogen-III oxidase family - - - - - - - - - - - - HemN_C,Radical_SAM k59_1157437_1 396588.Tgr7_1549 1.22e-65 209.0 COG1210@1|root,COG1210@2|Bacteria,1MV5F@1224|Proteobacteria,1RNDX@1236|Gammaproteobacteria,1WW21@135613|Chromatiales 135613|Chromatiales M UTP-glucose-1-phosphate uridylyltransferase - - 2.7.7.9 ko:K00963 ko00040,ko00052,ko00500,ko00520,ko01100,ko01130,map00040,map00052,map00500,map00520,map01100,map01130 M00129,M00361,M00362,M00549 R00289 RC00002 ko00000,ko00001,ko00002,ko01000 - - - NTP_transferase k59_196606_1 85643.Tmz1t_2252 1.89e-75 240.0 COG1066@1|root,COG1066@2|Bacteria,1MUJQ@1224|Proteobacteria,2VH93@28216|Betaproteobacteria,2KUIZ@206389|Rhodocyclales 206389|Rhodocyclales O DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function radA - - ko:K04485 - - - - ko00000,ko03400 - - - AAA_25,ATPase,ChlI,Lon_C k59_1498781_2 562973.HMPREF0059_00064 7e-17 81.6 COG0597@1|root,COG0597@2|Bacteria,2GKRX@201174|Actinobacteria,4D5GF@85005|Actinomycetales 201174|Actinobacteria MU This protein specifically catalyzes the removal of signal peptides from prolipoproteins lspA - 3.4.23.36 ko:K03101 ko03060,map03060 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_A8 k59_368994_1 1229909.NSED_08040 2.31e-179 520.0 COG0525@1|root,arCOG00808@2157|Archaea,41SBK@651137|Thaumarchaeota 651137|Thaumarchaeota J Anticodon-binding domain of tRNA - - 6.1.1.9 ko:K01873 ko00970,map00970 M00359,M00360 R03665 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,tRNA-synt_1 k59_816946_1 1249627.D779_4215 3.44e-90 291.0 COG4232@1|root,COG4232@2|Bacteria,1MU8W@1224|Proteobacteria,1RPF7@1236|Gammaproteobacteria,1WWWW@135613|Chromatiales 135613|Chromatiales CO Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps dsbD - 1.8.1.8 ko:K04084 - - - - ko00000,ko01000,ko03110 5.A.1.1 - - DsbC,DsbD,Thioredoxin_7 k59_1498787_1 1123261.AXDW01000004_gene2936 6.98e-38 133.0 COG2197@1|root,COG2197@2|Bacteria,1MWGM@1224|Proteobacteria,1RQ1J@1236|Gammaproteobacteria,1X3GJ@135614|Xanthomonadales 135614|Xanthomonadales K In Escherichia coli the protein UvrY is part of a two-component system along with BarA that is needed for efficient switching between glycolytic and gluconeogenic carbon sources possibly by regulating the Csr system - - - - - - - - - - - - GerE,Response_reg k59_1438383_1 1122194.AUHU01000015_gene2979 5.85e-28 113.0 COG1092@1|root,COG1092@2|Bacteria,1MUGB@1224|Proteobacteria,1RN7Z@1236|Gammaproteobacteria,464TP@72275|Alteromonadaceae 1236|Gammaproteobacteria J Specifically methylates the cytosine at position 1962 (m5C1962) of 23S rRNA rlmI - 2.1.1.191 ko:K06969 - - - - ko00000,ko01000,ko03009 - - - Methyltrans_SAM k59_1723734_2 436308.Nmar_0326 3.35e-32 115.0 arCOG08780@1|root,arCOG08780@2157|Archaea,41T84@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1325891_1 1120983.KB894575_gene723 1.09e-61 205.0 COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,2TRM1@28211|Alphaproteobacteria,1JQMN@119043|Rhodobiaceae 28211|Alphaproteobacteria G Tripartite ATP-independent periplasmic transporter, DctM component - - - - - - - - - - - - DctM k59_1157454_1 247634.GPB2148_756 4.37e-116 352.0 COG0535@1|root,COG0535@2|Bacteria,1NEM7@1224|Proteobacteria 1224|Proteobacteria M radical SAM domain protein - - - - - - - - - - - - Fer4_12,Fer4_14,Radical_SAM,SPASM k59_1498793_1 1121923.GPUN_0269 6.8e-10 59.7 COG0190@1|root,COG0190@2|Bacteria,1MWU4@1224|Proteobacteria,1RNSW@1236|Gammaproteobacteria,4649I@72275|Alteromonadaceae 1236|Gammaproteobacteria F Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate folD GO:0003674,GO:0003824,GO:0004477,GO:0004486,GO:0004488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006575,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016645,GO:0016646,GO:0016787,GO:0016810,GO:0016814,GO:0019238,GO:0019752,GO:0034641,GO:0042558,GO:0043436,GO:0043603,GO:0044237,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051186,GO:0055114,GO:0071704,GO:1901360,GO:1901564 1.5.1.5,3.5.4.9 ko:K01491 ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200 M00140,M00377 R01220,R01655 RC00202,RC00578 ko00000,ko00001,ko00002,ko01000 - - iSDY_1059.SDY_0281 THF_DHG_CYH,THF_DHG_CYH_C k59_1326892_1 1232683.ADIMK_2633 1.34e-134 388.0 COG0330@1|root,COG0330@2|Bacteria,1MUM8@1224|Proteobacteria,1RNW8@1236|Gammaproteobacteria,465XW@72275|Alteromonadaceae 1236|Gammaproteobacteria O COG0330 Membrane protease subunits, stomatin prohibitin homologs - - - - - - - - - - - - Band_7,Band_7_C k59_1326892_2 745411.B3C1_15227 3.33e-46 152.0 COG1585@1|root,COG1585@2|Bacteria,1N4FG@1224|Proteobacteria,1S4V9@1236|Gammaproteobacteria,1J6DW@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria OU COG1585 Membrane protein implicated in regulation of membrane protease activity - - - ko:K07340 - - - - ko00000 - - - NfeD k59_198044_1 396588.Tgr7_2062 6.64e-58 188.0 COG0565@1|root,COG0565@2|Bacteria,1N47Y@1224|Proteobacteria,1RPD3@1236|Gammaproteobacteria,1WVWE@135613|Chromatiales 135613|Chromatiales J Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA trmJ - 2.1.1.200 ko:K02533,ko:K15396 - - - - ko00000,ko01000,ko03016 - - - SpoU_methylase k59_761385_1 436308.Nmar_0282 2.83e-53 171.0 COG0839@1|root,arCOG04654@2157|Archaea,41SM8@651137|Thaumarchaeota 651137|Thaumarchaeota C PFAM NADH-ubiquinone plastoquinone oxidoreductase chain 6 - - 1.6.5.3 ko:K00339 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q3 k59_761385_2 436308.Nmar_0283 5.61e-39 131.0 COG0713@1|root,arCOG03073@2157|Archaea,41SPM@651137|Thaumarchaeota 651137|Thaumarchaeota C NADH ubiquinone oxidoreductase subunit 11 or 4L (chain K) - - 1.6.5.3 ko:K00340 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q2 k59_198045_1 517418.Ctha_0663 4.88e-17 86.3 COG2067@1|root,COG2067@2|Bacteria,1FDNA@1090|Chlorobi 1090|Chlorobi I PFAM membrane protein involved in aromatic hydrocarbon degradation - - - ko:K06076 - - - - ko00000,ko02000 1.B.9 - - Toluene_X k59_1158837_1 702113.PP1Y_AT25829 2.99e-148 434.0 COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,2TRKS@28211|Alphaproteobacteria,2K0M5@204457|Sphingomonadales 204457|Sphingomonadales I Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA acsA - 6.2.1.1 ko:K01895 ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200 M00357 R00235,R00236,R00316,R00926,R01354 RC00004,RC00012,RC00043,RC00070,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000,ko01004 - - - ACAS_N,AMP-binding,AMP-binding_C,DUF779 k59_1326893_1 713587.THITH_01715 1.31e-72 241.0 COG1067@1|root,COG1638@1|root,COG1067@2|Bacteria,COG1638@2|Bacteria,1MWGB@1224|Proteobacteria,1RMPC@1236|Gammaproteobacteria,1WXPW@135613|Chromatiales 135613|Chromatiales O Belongs to the peptidase S16 family - - - - - - - - - - - - AAA_32,Lon_C k59_423527_2 1121396.KB893057_gene2515 9.48e-104 325.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,2MI1N@213118|Desulfobacterales 28221|Deltaproteobacteria T sigma-54 factor interaction domain-containing protein pilR - - ko:K02667 ko02020,map02020 M00501 - - ko00000,ko00001,ko00002,ko02022,ko02035 - - - HTH_8,Response_reg,Sigma54_activat k59_423527_3 1121468.AUBR01000072_gene1025 6.37e-20 94.0 COG4191@1|root,COG4191@2|Bacteria,1UMSI@1239|Firmicutes,25GPV@186801|Clostridia,42JEM@68295|Thermoanaerobacterales 186801|Clostridia T His Kinase A (phosphoacceptor) domain - - 2.7.13.3 ko:K07709 ko02020,map02020 M00499 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA k59_1216657_1 67356.KL575631_gene7395 3.21e-13 74.7 COG2272@1|root,COG2272@2|Bacteria,2GJCN@201174|Actinobacteria 201174|Actinobacteria I Belongs to the type-B carboxylesterase lipase family - - - ko:K03929 - - - - ko00000,ko01000 - CE10 - COesterase k59_142666_1 469595.CSAG_04120 1.94e-82 258.0 COG3547@1|root,COG3547@2|Bacteria,1MUKH@1224|Proteobacteria,1RZTT@1236|Gammaproteobacteria 1236|Gammaproteobacteria L to GP 6723233 - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_313659_1 1244869.H261_15380 9.7e-59 203.0 COG2831@1|root,COG2831@2|Bacteria,1MWEC@1224|Proteobacteria,2U04Z@28211|Alphaproteobacteria,2JT2T@204441|Rhodospirillales 204441|Rhodospirillales U Haemolysin secretion/activation protein ShlB/FhaC/HecB - - - - - - - - - - - - POTRA_2,ShlB k59_878737_1 1565129.JSFF01000008_gene2603 6.92e-45 148.0 COG0745@1|root,COG0745@2|Bacteria,1RHDD@1224|Proteobacteria,1S67R@1236|Gammaproteobacteria,2QBVC@267890|Shewanellaceae 1236|Gammaproteobacteria T response regulator receiver - - - ko:K03413 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko02022,ko02035 - - - Response_reg k59_878737_2 94122.Shewana3_2218 3.64e-10 61.2 COG0643@1|root,COG2198@1|root,COG0643@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,1RMS6@1236|Gammaproteobacteria,2QAPV@267890|Shewanellaceae 1236|Gammaproteobacteria T CheA signal transduction histidine cheA GO:0000160,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0006935,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009605,GO:0009892,GO:0009893,GO:0009987,GO:0010562,GO:0010604,GO:0010605,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0018106,GO:0018193,GO:0018202,GO:0019220,GO:0019222,GO:0019538,GO:0023014,GO:0023052,GO:0031323,GO:0031324,GO:0031325,GO:0031399,GO:0031400,GO:0031401,GO:0032101,GO:0032268,GO:0032269,GO:0032270,GO:0032879,GO:0032991,GO:0035303,GO:0035304,GO:0035306,GO:0035307,GO:0035556,GO:0036211,GO:0040011,GO:0040012,GO:0042221,GO:0042330,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0045937,GO:0046777,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048583,GO:0050789,GO:0050794,GO:0050896,GO:0050920,GO:0051171,GO:0051172,GO:0051173,GO:0051174,GO:0051179,GO:0051234,GO:0051246,GO:0051247,GO:0051248,GO:0051270,GO:0051641,GO:0051649,GO:0051716,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0098561,GO:0140096,GO:1901564,GO:1901873,GO:1901875,GO:1902021,GO:2000145 2.7.13.3 ko:K03407 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 - - - CheW,CheY-binding,H-kinase_dim,HATPase_c,Hpt k59_1724772_1 909663.KI867150_gene1192 5.1e-67 217.0 COG3547@1|root,COG3547@2|Bacteria,1MUKH@1224|Proteobacteria,42NNJ@68525|delta/epsilon subdivisions,2WKP9@28221|Deltaproteobacteria,2MRST@213462|Syntrophobacterales 28221|Deltaproteobacteria L PFAM transposase IS116 IS110 IS902 family - - - - - - - - - - - - DEDD_Tnp_IS110,DUF2924,Transposase_20 k59_534434_1 1247963.JPHU01000009_gene2402 1.19e-30 113.0 COG0261@1|root,COG0261@2|Bacteria,1MZEW@1224|Proteobacteria,2UBT3@28211|Alphaproteobacteria 28211|Alphaproteobacteria J This protein binds to 23S rRNA in the presence of protein L20 rplU GO:0003674,GO:0003735,GO:0005198 - ko:K02888 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - HHH_5,Ribosomal_L21p k59_534434_2 991905.SL003B_4144 1.18e-41 138.0 COG0211@1|root,COG0211@2|Bacteria,1MZGH@1224|Proteobacteria,2UBUX@28211|Alphaproteobacteria,4BQNP@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria J Belongs to the bacterial ribosomal protein bL27 family rpmA GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - ko:K02899 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L27 k59_534434_3 1122137.AQXF01000003_gene1936 1.02e-135 392.0 COG0536@1|root,COG0536@2|Bacteria,1MUGZ@1224|Proteobacteria,2TR5I@28211|Alphaproteobacteria 28211|Alphaproteobacteria S An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control obg - - ko:K03979 - - - - ko00000,ko01000,ko03009 - - - GTP1_OBG,MMR_HSR1 k59_30913_1 316067.Geob_1215 1.14e-79 256.0 COG0296@1|root,COG0296@2|Bacteria,1MVM7@1224|Proteobacteria,42MKI@68525|delta/epsilon subdivisions,2WIQJ@28221|Deltaproteobacteria,43TCE@69541|Desulfuromonadales 28221|Deltaproteobacteria G Domain of unknown function (DUF3459) treZ - 3.2.1.141 ko:K01236 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R09995,R11256 RC00049 ko00000,ko00001,ko00002,ko01000 - CBM48,GH13 - Alpha-amylase,CBM_48,DUF3459 k59_1326902_1 59196.RICGR_1092 2.63e-95 290.0 COG4992@1|root,COG4992@2|Bacteria,1MV3C@1224|Proteobacteria,1RMV1@1236|Gammaproteobacteria,1JDGU@118969|Legionellales 1236|Gammaproteobacteria E Aminotransferase class-III rocD - 2.6.1.13 ko:K00819 ko00330,ko01100,ko01110,ko01130,map00330,map01100,map01110,map01130 - R00667 RC00006,RC00062 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_3 k59_878751_1 391735.Veis_4953 1.05e-17 83.2 COG1073@1|root,COG1073@2|Bacteria 2|Bacteria S thiolester hydrolase activity - - - - - - - - - - - - Abhydrolase_6,Hydrolase_4,Polysacc_synt_3,Polysacc_synt_C k59_878751_2 1198452.Jab_1c09120 2.39e-22 99.8 COG2199@1|root,COG2203@1|root,COG3614@1|root,COG2199@2|Bacteria,COG2203@2|Bacteria,COG3614@2|Bacteria,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria,2VQP8@28216|Betaproteobacteria,476AA@75682|Oxalobacteraceae 28216|Betaproteobacteria T CHASE - - - - - - - - - - - - CHASE,GAF_2,GGDEF,PAS_8 k59_255746_1 1206729.BAFZ01000089_gene2388 6.98e-20 92.4 COG0277@1|root,COG0277@2|Bacteria,2GJ33@201174|Actinobacteria,4FUJD@85025|Nocardiaceae 201174|Actinobacteria C D-arabinono-1,4-lactone oxidase - GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005975,GO:0005996,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0016020,GO:0016051,GO:0016053,GO:0016491,GO:0016627,GO:0016632,GO:0019752,GO:0019852,GO:0019853,GO:0030312,GO:0042364,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046364,GO:0046394,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0071944,GO:0080049,GO:1901576 1.1.3.8 ko:K00103 ko00053,ko01100,map00053,map01100 M00129 R00647,R03184,R10053 RC00195,RC00346,RC00869 ko00000,ko00001,ko00002,ko01000 - - - ALO,FAD_binding_4 k59_1158865_1 240016.ABIZ01000001_gene3597 1.95e-56 192.0 COG1861@1|root,COG1861@2|Bacteria,46UVT@74201|Verrucomicrobia 74201|Verrucomicrobia M Transposase DDE domain group 1 - - - - - - - - - - - - DDE_Tnp_1_4 k59_255747_1 5671.XP_001467181.1 1.01e-07 60.8 COG0639@1|root,KOG0374@2759|Eukaryota,3XT6K@5653|Kinetoplastida 5653|Kinetoplastida T serine threonine - - - - - - - - - - - - Metallophos k59_1158866_1 316407.85676972 3.86e-172 514.0 COG2911@1|root,COG2911@2|Bacteria,1MUVD@1224|Proteobacteria,1RMMF@1236|Gammaproteobacteria,3XPEG@561|Escherichia 1236|Gammaproteobacteria S Part of the translocation and assembly module (TAM) autotransporter assembly complex, which functions in translocation of autotransporters across the outer membrane. In reconstituted TAM this subunit (Ag43, AC P39180) is not necessary for substrate penetration in the outer membrane. Substrate binding to TamA moves its POTRA domains about 30 Angstroms into the periplasm, which would deform either the outer membrane or TamB and may provide force to reset TAM ytfN GO:0002790,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0032940,GO:0032991,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944,GO:0097347 - ko:K09800 - - - - ko00000,ko02000 - - - TamB k59_30933_1 710696.Intca_2538 9.96e-22 93.6 COG0520@1|root,COG0520@2|Bacteria,2GP7W@201174|Actinobacteria,4FFVG@85021|Intrasporangiaceae 201174|Actinobacteria E Aminotransferase class-V - - - - - - - - - - - - Aminotran_5 k59_30933_2 1128421.JAGA01000002_gene1043 1.39e-30 116.0 COG0350@1|root,COG0350@2|Bacteria,2NPJ5@2323|unclassified Bacteria 2|Bacteria L Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated ogt - 2.1.1.63 ko:K00567 - - - - ko00000,ko01000,ko03400 - - - Ada_Zn_binding,DNA_binding_1 k59_88081_1 713587.THITH_09625 2.78e-48 162.0 COG2738@1|root,COG2738@2|Bacteria,1RDJH@1224|Proteobacteria,1S4QY@1236|Gammaproteobacteria,1X0PS@135613|Chromatiales 135613|Chromatiales S Putative neutral zinc metallopeptidase - - - ko:K06973 - - - - ko00000 - - - Zn_peptidase_2 k59_878775_2 69279.BG36_08935 2.76e-17 85.9 COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,2TR4Q@28211|Alphaproteobacteria,43H1D@69277|Phyllobacteriaceae 28211|Alphaproteobacteria S protein conserved in bacteria - - - ko:K07793 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.80.1 - - TctA k59_423556_1 330214.NIDE1216 4.65e-12 65.5 COG0276@1|root,COG0276@2|Bacteria,3J0P9@40117|Nitrospirae 40117|Nitrospirae H Catalyzes the ferrous insertion into protoporphyrin IX hemH - 4.99.1.1,4.99.1.9 ko:K01772 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R00310,R11329 RC01012 ko00000,ko00001,ko00002,ko01000 - - - Ferrochelatase k59_423556_2 330214.NIDE1215 7.17e-60 194.0 COG0407@1|root,COG0407@2|Bacteria,3J0C3@40117|Nitrospirae 40117|Nitrospirae H Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III hemE GO:0003674,GO:0003824,GO:0004853,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.1.37 ko:K01599 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R03197,R04972 RC00872 ko00000,ko00001,ko00002,ko01000 - - - URO-D k59_88085_1 1131266.ARWQ01000009_gene955 5.9e-78 243.0 COG0079@1|root,arCOG04273@2157|Archaea,41SGU@651137|Thaumarchaeota 651137|Thaumarchaeota E PFAM Aminotransferase class I and II - - 4.1.1.81 ko:K04720 ko00860,map00860 - R06530 RC00517 ko00000,ko00001,ko01000 - - - Aminotran_1_2 k59_1566318_1 999141.GME_07859 7.32e-87 262.0 COG0842@1|root,COG0842@2|Bacteria,1MUH1@1224|Proteobacteria,1RP0Z@1236|Gammaproteobacteria,1XHEP@135619|Oceanospirillales 135619|Oceanospirillales V Transport permease protein - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane k59_656216_1 1123519.PSJM300_02420 6.93e-74 238.0 COG0606@1|root,COG0606@2|Bacteria,1MU4R@1224|Proteobacteria,1RMB9@1236|Gammaproteobacteria,1YZQ3@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria O Magnesium chelatase, subunit comM GO:0003674,GO:0003824,GO:0004176,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019538,GO:0042623,GO:0043170,GO:0044238,GO:0070011,GO:0071704,GO:0140096,GO:1901564 - ko:K07391 - - - - ko00000 - - - ChlI,Mg_chelatase,Mg_chelatase_C k59_1731811_1 264198.Reut_B5027 3.8e-42 155.0 COG2271@1|root,COG2271@2|Bacteria,1P24P@1224|Proteobacteria,2VIKS@28216|Betaproteobacteria,1K0X4@119060|Burkholderiaceae 28216|Betaproteobacteria G Major facilitator superfamily MFS_1 - - - ko:K08195 - - - - ko00000,ko02000 2.A.1.15 - - MFS_1,MFS_4 k59_322925_1 1122137.AQXF01000001_gene3117 3.02e-63 198.0 COG0526@1|root,COG0526@2|Bacteria,1RI3N@1224|Proteobacteria,2TSEW@28211|Alphaproteobacteria 28211|Alphaproteobacteria CO Thiol disulfide interchange protein dsbE - - ko:K02199 - - - - ko00000,ko03110 - - - AhpC-TSA,Redoxin k59_322925_2 1122137.AQXF01000001_gene3118 2.49e-100 311.0 COG1138@1|root,COG1138@2|Bacteria,1MUQS@1224|Proteobacteria,2TRNG@28211|Alphaproteobacteria 28211|Alphaproteobacteria O Cytochrome c-type biogenesis protein ccmF - - ko:K02198 - - - - ko00000,ko02000 9.B.14.1 - - CcmF_C,Cytochrom_C_asm k59_1447335_1 195105.CN97_05695 6.27e-76 257.0 COG0013@1|root,COG0013@2|Bacteria,1MU9A@1224|Proteobacteria,2TQV4@28211|Alphaproteobacteria 28211|Alphaproteobacteria J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain alaS GO:0003674,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016597,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.7 ko:K01872 ko00970,map00970 M00359,M00360 R03038 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DHHA1,tRNA-synt_2c,tRNA_SAD k59_39654_1 198628.Dda3937_01296 1.23e-101 320.0 COG0525@1|root,COG0525@2|Bacteria,1MV7B@1224|Proteobacteria,1RNEB@1236|Gammaproteobacteria,2JCTW@204037|Dickeya 1236|Gammaproteobacteria J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner valS GO:0000287,GO:0002161,GO:0003674,GO:0003824,GO:0004812,GO:0004832,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006417,GO:0006418,GO:0006438,GO:0006450,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0016070,GO:0016787,GO:0016788,GO:0016874,GO:0016875,GO:0019222,GO:0019538,GO:0019752,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0034248,GO:0034250,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045727,GO:0045903,GO:0046483,GO:0046872,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0052689,GO:0060255,GO:0061475,GO:0065007,GO:0065008,GO:0071704,GO:0080090,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:2000112 6.1.1.9 ko:K01873 ko00970,map00970 M00359,M00360 R03665 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iECH74115_1262.ECH74115_5779,iECNA114_1301.ECNA114_4481,iECO26_1355.ECO26_5428,iECSP_1301.ECSP_5359,iECs_1301.ECs5235,iG2583_1286.G2583_5088,iJN746.PP_0977,iSBO_1134.SBO_4182,iSSON_1240.SSON_4443,iYL1228.KPN_04663,iZ_1308.Z5870 Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1 k59_207181_1 1045855.DSC_14475 3.68e-32 122.0 COG4638@1|root,COG4638@2|Bacteria,1MWXW@1224|Proteobacteria,1S9NJ@1236|Gammaproteobacteria,1X5C8@135614|Xanthomonadales 135614|Xanthomonadales P COG4638 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit - - 1.14.12.1,1.14.15.7 ko:K00499,ko:K16319 ko00260,ko00627,ko01120,map00260,map00627,map01120 M00637 R00823,R00825,R07409 RC00087,RC00192 br01602,ko00000,ko00001,ko00002,ko01000 - - - Rieske,Ring_hydroxyl_A k59_207181_2 1415779.JOMH01000001_gene745 4.91e-10 59.7 COG1028@1|root,COG1028@2|Bacteria,1MW50@1224|Proteobacteria,1RRIH@1236|Gammaproteobacteria,1X778@135614|Xanthomonadales 135614|Xanthomonadales IQ Enoyl-(Acyl carrier protein) reductase - - 1.3.1.25 ko:K05783 ko00362,ko00364,ko00622,ko01100,ko01120,ko01220,map00362,map00364,map00622,map01100,map01120,map01220 M00551 R00813,R05292,R05293,R05309,R05314,R08111,R08112,R08113 RC00271,RC01326,RC01327 br01602,ko00000,ko00001,ko00002,ko01000 - - - adh_short k59_938765_1 1123248.KB893316_gene4690 1.49e-13 75.9 COG5520@1|root,COG5520@2|Bacteria,4NEG7@976|Bacteroidetes,1IQE2@117747|Sphingobacteriia 976|Bacteroidetes M O-Glycosyl hydrolase family 30 - - - - - - - - - - - - CBM_6,Glyco_hydr_30_2,Glyco_hydro_30C k59_1447341_1 935863.AWZR01000005_gene2145 1.82e-76 246.0 COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,1RMUR@1236|Gammaproteobacteria,1X4E6@135614|Xanthomonadales 135614|Xanthomonadales V ABC-type multidrug transport system ATPase and permease bapA - - ko:K18893 ko02010,map02010 - - - ko00000,ko00001,ko02000 3.A.1 - - ABC_membrane,ABC_tran k59_1223798_1 1415778.JQMM01000001_gene501 2.9e-106 314.0 COG0548@1|root,COG0548@2|Bacteria,1MU17@1224|Proteobacteria,1RNKK@1236|Gammaproteobacteria,1J5E4@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria F Belongs to the acetylglutamate kinase family. ArgB subfamily argB GO:0003674,GO:0003824,GO:0003991,GO:0004042,GO:0005488,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0008080,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016407,GO:0016410,GO:0016597,GO:0016740,GO:0016746,GO:0016747,GO:0016772,GO:0016774,GO:0019752,GO:0031406,GO:0033554,GO:0034618,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0050896,GO:0051716,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.3.1.1,2.7.2.8 ko:K00930,ko:K22478 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028,M00845 R00259,R02649 RC00002,RC00004,RC00043,RC00064 ko00000,ko00001,ko00002,ko01000 - - iAPECO1_1312.APECO1_2508,iB21_1397.B21_03793,iEC55989_1330.EC55989_4441,iECB_1328.ECB_03844,iECDH10B_1368.ECDH10B_4147,iECDH1ME8569_1439.ECDH1ME8569_3827,iECD_1391.ECD_03844,iECH74115_1262.ECH74115_5419,iECIAI1_1343.ECIAI1_4167,iECO103_1326.ECO103_4715,iECOK1_1307.ECOK1_4431,iECS88_1305.ECS88_4414,iECSE_1348.ECSE_4252,iETEC_1333.ETEC_4227,iEcE24377_1341.EcE24377A_4498,iEcHS_1320.EcHS_A4193,iEcolC_1368.EcolC_4057,iSbBS512_1146.SbBS512_E4445,iUMN146_1321.UM146_20050,iUMNK88_1353.UMNK88_4797,iUTI89_1310.UTI89_C4550,iY75_1357.Y75_RS17255 AA_kinase,NAT k59_1566329_1 204669.Acid345_1482 1.38e-16 84.3 COG0527@1|root,COG0527@2|Bacteria,3Y34W@57723|Acidobacteria,2JHV2@204432|Acidobacteriia 204432|Acidobacteriia E Belongs to the aspartokinase family - - 2.7.2.4 ko:K00928 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00017,M00018,M00033,M00525,M00526,M00527 R00480 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase,ACT k59_938778_2 1120963.KB894497_gene2141 1.09e-58 206.0 COG0584@1|root,COG4222@1|root,COG0584@2|Bacteria,COG4222@2|Bacteria,1N0B0@1224|Proteobacteria,1RRMG@1236|Gammaproteobacteria 1236|Gammaproteobacteria C protein conserved in bacteria - - - - - - - - - - - - Phytase-like k59_379291_1 243090.RB3271 4.68e-16 79.7 COG0515@1|root,COG0515@2|Bacteria,2IX48@203682|Planctomycetes 203682|Planctomycetes KLT COG0515 Serine threonine protein - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase k59_656248_2 269796.Rru_A2444 2.7e-14 76.3 COG1309@1|root,COG1309@2|Bacteria,1RKBU@1224|Proteobacteria,2UAGR@28211|Alphaproteobacteria,2JSXI@204441|Rhodospirillales 204441|Rhodospirillales K Bacterial regulatory proteins, tetR family - - - - - - - - - - - - TetR_N k59_39664_2 1229909.NSED_02950 1.32e-20 87.8 COG1938@1|root,arCOG00347@2157|Archaea 2157|Archaea S COG1938 Archaeal enzymes of ATP-grasp superfamily - - - ko:K06869 - - - - ko00000 - - - PAC2 k59_323936_1 1265313.HRUBRA_02742 7.09e-79 242.0 COG3917@1|root,COG3917@2|Bacteria,1MV6E@1224|Proteobacteria 1224|Proteobacteria Q 2-hydroxychromene-2-carboxylate isomerase MA20_23730 - - - - - - - - - - - DSBA k59_769723_1 452637.Oter_0692 1.07e-81 256.0 COG1364@1|root,COG1364@2|Bacteria,46SEP@74201|Verrucomicrobia,3K7UB@414999|Opitutae 414999|Opitutae E Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate argJ - 2.3.1.1,2.3.1.35 ko:K00620 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028 R00259,R02282 RC00004,RC00064 ko00000,ko00001,ko00002,ko01000 - - - ArgJ k59_718793_1 519989.ECTPHS_07097 2.52e-14 72.4 COG1008@1|root,COG1008@2|Bacteria,1MV7V@1224|Proteobacteria,1RNI4@1236|Gammaproteobacteria,1WXM2@135613|Chromatiales 135613|Chromatiales C TIGRFAM proton-translocating NADH-quinone oxidoreductase, chain M - - 1.6.5.3 ko:K00342 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q5_N,Proton_antipo_M k59_718793_2 396588.Tgr7_0999 5.84e-39 143.0 COG1007@1|root,COG1007@2|Bacteria,1MV56@1224|Proteobacteria,1RPJB@1236|Gammaproteobacteria,1WW6G@135613|Chromatiales 135613|Chromatiales C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoN - 1.6.5.3 ko:K00343 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Proton_antipo_M k59_888942_2 566466.NOR53_2555 7.39e-12 68.6 COG1629@1|root,COG4771@2|Bacteria,1MWKN@1224|Proteobacteria,1T3IM@1236|Gammaproteobacteria,1J7EQ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P COG1629 Outer membrane receptor proteins, mostly Fe transport - - - - - - - - - - - - Plug,TonB_dep_Rec k59_150866_2 436308.Nmar_1051 4.48e-79 244.0 arCOG10557@1|root,arCOG10557@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_96528_1 452637.Oter_1629 6.39e-45 154.0 COG0266@1|root,COG0266@2|Bacteria 2|Bacteria L class I DNA-(apurinic or apyrimidinic site) endonuclease activity fpg - 3.2.2.23,4.2.99.18 ko:K10563 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - Fapy_DNA_glyco,H2TH,zf-FPG_IleRS k59_96528_2 1048339.KB913029_gene2518 1.45e-14 73.9 COG0451@1|root,COG0451@2|Bacteria,2I2UT@201174|Actinobacteria,4EXF8@85013|Frankiales 201174|Actinobacteria M Polysaccharide biosynthesis protein galE1 GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 4.2.1.46,5.1.3.2 ko:K01710,ko:K01784 ko00052,ko00520,ko00521,ko00523,ko00525,ko01055,ko01100,ko01130,map00052,map00520,map00521,map00523,map00525,map01055,map01100,map01130 M00361,M00362,M00632,M00793 R00291,R02984,R06513 RC00289,RC00402 ko00000,ko00001,ko00002,ko01000 - - - Epimerase,GDP_Man_Dehyd k59_487406_1 158500.BV97_02416 4.5e-129 377.0 COG0174@1|root,COG0174@2|Bacteria,1MUGQ@1224|Proteobacteria,2TSCR@28211|Alphaproteobacteria,2K06N@204457|Sphingomonadales 204457|Sphingomonadales E highly regulated protein controlled by the addition removal of adenylyl groups by adenylyltransferase from specific tyrosine residues glnA - 6.3.1.2 ko:K01915 ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 - R00253 RC00010,RC02798 ko00000,ko00001,ko01000,ko04147 - - - Gln-synt_C,Gln-synt_N k59_542443_1 1144305.PMI02_01197 9.3e-24 95.5 COG1670@1|root,COG1670@2|Bacteria,1RCX2@1224|Proteobacteria,2U97G@28211|Alphaproteobacteria,2K59G@204457|Sphingomonadales 204457|Sphingomonadales J COG1670 acetyltransferases, including N-acetylases of ribosomal proteins - - - - - - - - - - - - Acetyltransf_3 k59_542443_2 161528.ED21_19582 1.53e-19 85.5 COG1670@1|root,COG1670@2|Bacteria,1MZEK@1224|Proteobacteria,2UDWE@28211|Alphaproteobacteria,2KD0D@204457|Sphingomonadales 204457|Sphingomonadales J COG1670 acetyltransferases, including N-acetylases of ribosomal proteins - - - - - - - - - - - - Acetyltransf_3 k59_40848_1 1123037.AUDE01000010_gene2358 6.19e-25 101.0 2CCVV@1|root,2Z7YU@2|Bacteria,4NDUA@976|Bacteroidetes,1HXAA@117743|Flavobacteriia 976|Bacteroidetes S Putative MetA-pathway of phenol degradation - - - - - - - - - - - - Phenol_MetA_deg k59_40848_2 1046627.BZARG_286 4.03e-07 50.1 2EHT5@1|root,32ZJC@2|Bacteria,4NVEE@976|Bacteroidetes,1I5FZ@117743|Flavobacteriia 976|Bacteroidetes S Domain of unknown function (DUF4834) - - - - - - - - - - - - DUF4834 k59_828616_1 1156919.QWC_00540 1.46e-92 280.0 COG0235@1|root,COG0235@2|Bacteria,1MWP9@1224|Proteobacteria,2VMZ3@28216|Betaproteobacteria,3T34Q@506|Alcaligenaceae 28216|Betaproteobacteria G Class II aldolase adducin domain protein fucA_3 - 4.1.2.17 ko:K01628 ko00051,ko01120,map00051,map01120 - R02262 RC00603,RC00604 ko00000,ko00001,ko01000 - - - Aldolase_II k59_96555_1 1197477.IA57_09980 1.53e-86 271.0 COG1132@1|root,COG1132@2|Bacteria,4NDY6@976|Bacteroidetes,1HWU3@117743|Flavobacteriia 976|Bacteroidetes V ABC transporter mdlA - - ko:K18889 ko02010,map02010 M00707 - - ko00000,ko00001,ko00002,ko02000 3.A.1.106.13,3.A.1.106.5 - - ABC_membrane,ABC_tran k59_150905_1 1229909.NSED_00090 8.25e-65 211.0 COG1797@1|root,arCOG00106@2157|Archaea,41SBP@651137|Thaumarchaeota 651137|Thaumarchaeota H Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source cbiA - 6.3.5.11,6.3.5.9 ko:K02224 ko00860,ko01100,ko01120,map00860,map01100,map01120 - R05224,R05815 RC00010,RC01301 ko00000,ko00001,ko01000 - - - CbiA,GATase_3 k59_542461_1 1122137.AQXF01000007_gene3560 1.1e-54 193.0 COG0642@1|root,COG0642@2|Bacteria,1NXDJ@1224|Proteobacteria 1224|Proteobacteria T Histidine kinase - - - - - - - - - - - - HATPase_c,HisKA,Response_reg k59_1109663_1 1249627.D779_1725 1.39e-08 55.5 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1WWB8@135613|Chromatiales 135613|Chromatiales V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_1109663_2 1385935.N836_33495 1.13e-08 61.2 COG1566@1|root,COG1566@2|Bacteria,1G2SH@1117|Cyanobacteria 1117|Cyanobacteria V Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - - - - - - - - - - Biotin_lipoyl_2,HlyD_D23 k59_431691_1 926551.KB900715_gene2119 1.48e-11 62.8 COG0212@1|root,COG0212@2|Bacteria,4NM97@976|Bacteroidetes,1I19B@117743|Flavobacteriia,1ERZI@1016|Capnocytophaga 976|Bacteroidetes H 5-formyltetrahydrofolate cyclo-ligase ygfA - 6.3.3.2 ko:K01934 ko00670,ko01100,map00670,map01100 - R02301 RC00183 ko00000,ko00001,ko01000 - - - 5-FTHF_cyc-lig k59_431691_2 1347342.BN863_33080 1.36e-48 165.0 COG3608@1|root,COG3608@2|Bacteria,4NE8S@976|Bacteroidetes,1HXAJ@117743|Flavobacteriia 976|Bacteroidetes S succinylglutamate desuccinylase - - - ko:K06987 - - - - ko00000 - - - AstE_AspA k59_940086_1 983544.Lacal_0793 4.4e-73 238.0 COG0073@1|root,COG0143@1|root,COG0073@2|Bacteria,COG0143@2|Bacteria,4NECB@976|Bacteroidetes,1HXHI@117743|Flavobacteriia 976|Bacteroidetes J Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation metG GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.10 ko:K01874 ko00450,ko00970,map00450,map00970 M00359,M00360 R03659,R04773 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,tRNA-synt_1g,tRNA_bind k59_940086_2 1121897.AUGO01000002_gene2096 5.1e-09 56.2 COG2771@1|root,COG3292@1|root,COG2771@2|Bacteria,COG3292@2|Bacteria,4NG28@976|Bacteroidetes,1I1IG@117743|Flavobacteriia,2P016@237|Flavobacterium 976|Bacteroidetes KT Regulator - - - - - - - - - - - - GAF_2,GerE,HATPase_c,HisKA,Reg_prop,Response_reg,Y_Y_Y k59_828641_1 1229780.BN381_60023 3.95e-16 84.3 COG0457@1|root,COG2114@1|root,COG3899@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG3899@2|Bacteria,2GJRI@201174|Actinobacteria,3UXGT@52018|unclassified Actinobacteria (class) 201174|Actinobacteria T Adenylyl- / guanylyl cyclase, catalytic domain - - - - - - - - - - - - AAA_16,Guanylate_cyc,TPR_12 k59_431706_1 378806.STAUR_7722 5.67e-135 402.0 COG3344@1|root,COG3344@2|Bacteria,1MVI1@1224|Proteobacteria,42Y93@68525|delta/epsilon subdivisions,2WU1Y@28221|Deltaproteobacteria,2YWK2@29|Myxococcales 28221|Deltaproteobacteria L Reverse transcriptase (RNA-dependent DNA polymerase) - - - - - - - - - - - - RVT_1 k59_1674961_1 436308.Nmar_1710 1.43e-42 142.0 arCOG03681@1|root,arCOG03681@2157|Archaea,41T6V@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_208538_2 765420.OSCT_0880 1.86e-29 116.0 COG0150@1|root,COG0150@2|Bacteria,2G5YZ@200795|Chloroflexi,374UG@32061|Chloroflexia 32061|Chloroflexia F AIR synthase related protein domain protein purM - 6.3.3.1 ko:K01933 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04208 RC01100 ko00000,ko00001,ko00002,ko01000 - - - AIRS,AIRS_C k59_487443_1 243159.AFE_2717 3.8e-12 64.7 2DPCV@1|root,331IV@2|Bacteria,1R38F@1224|Proteobacteria,1T64S@1236|Gammaproteobacteria,2ND4K@225057|Acidithiobacillales 225057|Acidithiobacillales S Protein of Unknown function (DUF2784) - - - - - - - - - - - - DUF2784 k59_487443_2 257313.BP2280 3.71e-48 163.0 COG2897@1|root,COG2897@2|Bacteria,1MW4B@1224|Proteobacteria,2VHAX@28216|Betaproteobacteria,3T2UC@506|Alcaligenaceae 28216|Betaproteobacteria P Sulfurtransferase sseA - 2.8.1.1,2.8.1.2 ko:K01011 ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122 - R01931,R03105,R03106 RC00214 ko00000,ko00001,ko01000 - - - Rhodanese k59_605696_1 85643.Tmz1t_1345 3.28e-18 83.2 COG3748@1|root,COG3748@2|Bacteria,1MWHB@1224|Proteobacteria,2VIC0@28216|Betaproteobacteria,2KV1G@206389|Rhodocyclales 206389|Rhodocyclales S Pfam:DUF989 - - - - - - - - - - - - Urate_ox_N k59_605696_2 371042.NG99_16650 6.13e-49 168.0 COG1975@1|root,COG1975@2|Bacteria,1R3RT@1224|Proteobacteria,1RQNB@1236|Gammaproteobacteria,3X705@551|Erwinia 1236|Gammaproteobacteria O XdhC and CoxI family xdhC - - ko:K07402 - - - - ko00000 - - - XdhC_C,XdhC_CoxI k59_1567655_1 1123392.AQWL01000002_gene1724 1.84e-23 94.7 2CECF@1|root,32RZM@2|Bacteria,1N130@1224|Proteobacteria,2WC6M@28216|Betaproteobacteria,1KT5Z@119069|Hydrogenophilales 119069|Hydrogenophilales S pilin assembly protein - - - - - - - - - - - - - k59_1109689_1 1298865.H978DRAFT_0007 1.63e-34 135.0 COG1629@1|root,COG4771@2|Bacteria,1N6JG@1224|Proteobacteria,1RP10@1236|Gammaproteobacteria,465FE@72275|Alteromonadaceae 1236|Gammaproteobacteria P Carboxypeptidase regulatory-like domain - - - - - - - - - - - - CarboxypepD_reg,Plug,TonB_dep_Rec k59_718879_1 1391646.AVSU01000063_gene3373 6.82e-21 93.6 COG0457@1|root,COG0457@2|Bacteria,1VIPH@1239|Firmicutes,25D6R@186801|Clostridia 186801|Clostridia S Protein of unknown function (DUF2971) - - - - - - - - - - - - DUF2971 k59_1674969_1 1117647.M5M_02360 3.59e-101 311.0 COG2172@1|root,COG2208@1|root,COG3437@1|root,COG2172@2|Bacteria,COG2208@2|Bacteria,COG3437@2|Bacteria,1N4K5@1224|Proteobacteria,1RNYP@1236|Gammaproteobacteria,1J59Q@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T response regulator rsbU - - ko:K20977 ko02020,ko02025,map02020,map02025 M00820 - - ko00000,ko00001,ko00002,ko02022 - - - HATPase_c_2,Response_reg,SpoIIE k59_542513_1 987059.RBXJA2T_16907 6.31e-94 286.0 COG0055@1|root,COG0055@2|Bacteria,1MUFU@1224|Proteobacteria,2VHDZ@28216|Betaproteobacteria,1KJX9@119065|unclassified Burkholderiales 28216|Betaproteobacteria C Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits atpD - 3.6.3.14 ko:K02112 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - - ATP-synt_ab,ATP-synt_ab_N k59_542513_2 1144319.PMI16_04168 5.88e-07 48.9 COG0355@1|root,COG0355@2|Bacteria,1RHE4@1224|Proteobacteria,2VR2R@28216|Betaproteobacteria,474C5@75682|Oxalobacteraceae 28216|Betaproteobacteria C Produces ATP from ADP in the presence of a proton gradient across the membrane atpC - - ko:K02114 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt_DE,ATP-synt_DE_N k59_1169071_1 1334046.AYTB01000008_gene2843 2.19e-12 67.0 COG0745@1|root,COG0745@2|Bacteria,1TPWS@1239|Firmicutes,4H9KP@91061|Bacilli,26DAH@186818|Planococcaceae 91061|Bacilli T COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain phoP - - ko:K07658 ko02020,map02020 M00434 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Trans_reg_C k59_1169071_2 589865.DaAHT2_0094 6.88e-08 56.6 COG0784@1|root,COG5002@1|root,COG0784@2|Bacteria,COG5002@2|Bacteria,1NC9X@1224|Proteobacteria,43BU6@68525|delta/epsilon subdivisions,2X7KH@28221|Deltaproteobacteria 28221|Deltaproteobacteria T Histidine kinase - - - - - - - - - - - - HATPase_c,HisKA,Hpt,PAS,Response_reg k59_1169071_3 880073.Calab_3515 2.61e-06 48.9 COG0471@1|root,COG0471@2|Bacteria 2|Bacteria P metal ion transport sac1 - - ko:K14445 - - - - ko00000,ko02000 2.A.47.1 - - CitMHS,Na_sulph_symp,TrkA_C k59_1225078_1 882.DVU_0702 1.37e-13 74.3 COG0737@1|root,COG0737@2|Bacteria,1NDBC@1224|Proteobacteria,42V2W@68525|delta/epsilon subdivisions,2X5T9@28221|Deltaproteobacteria,2MBXJ@213115|Desulfovibrionales 28221|Deltaproteobacteria C Cytochrome c554 and c-prime - - - - - - - - - - - - Cytochrome_C554 k59_1225078_2 682795.AciX8_1911 1.61e-18 86.7 COG1573@1|root,COG1573@2|Bacteria,3Y43G@57723|Acidobacteria,2JJ46@204432|Acidobacteriia 204432|Acidobacteriia L TIGRFAM Phage SPO1 DNA polymerase-related protein - - 3.2.2.27 ko:K21929 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - UDG k59_1620621_1 1535287.JP74_20375 1.13e-07 57.0 COG1082@1|root,COG1082@2|Bacteria 2|Bacteria G myo-inosose-2 dehydratase activity - - - - - - - - - - - - AP_endonuc_2 k59_1620621_2 247634.GPB2148_2415 6.46e-19 86.7 COG0108@1|root,COG0108@2|Bacteria,1MU8P@1224|Proteobacteria,1RQ49@1236|Gammaproteobacteria 1236|Gammaproteobacteria H Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate ribB - 3.5.4.25,4.1.99.12 ko:K14652 ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110 M00125,M00840 R00425,R07281 RC00293,RC01792,RC01815,RC02504 ko00000,ko00001,ko00002,ko01000 - - - DHBP_synthase,GTP_cyclohydro2 k59_1733179_1 983920.Y88_2755 1.03e-102 313.0 COG0374@1|root,COG0374@2|Bacteria,1MWFJ@1224|Proteobacteria,2TSH1@28211|Alphaproteobacteria 28211|Alphaproteobacteria C Belongs to the NiFe NiFeSe hydrogenase large subunit family hupL GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 1.12.99.6 ko:K06281 ko00633,ko01120,map00633,map01120 - R08034 RC00250 ko00000,ko00001,ko01000 - - - NiFeSe_Hases k59_1109703_1 1161401.ASJA01000003_gene2777 9.45e-108 321.0 COG2706@1|root,COG2706@2|Bacteria,1R2EP@1224|Proteobacteria,2TZID@28211|Alphaproteobacteria,43Z04@69657|Hyphomonadaceae 28211|Alphaproteobacteria G 6-phosphogluconolactonase activity - - - - - - - - - - - - - k59_940110_1 1144305.PMI02_02741 3.89e-83 257.0 COG1680@1|root,COG1680@2|Bacteria,1MY4Y@1224|Proteobacteria,2TYCG@28211|Alphaproteobacteria,2K2G5@204457|Sphingomonadales 204457|Sphingomonadales V COG1680 Beta-lactamase class C and other penicillin binding proteins - - - - - - - - - - - - Beta-lactamase k59_431747_1 1379270.AUXF01000002_gene1585 5.32e-77 253.0 COG0515@1|root,COG0515@2|Bacteria,1ZUMJ@142182|Gemmatimonadetes 142182|Gemmatimonadetes KLT Protein kinase domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - PD40,Pkinase k59_487492_1 1056512.D515_02639 1.28e-101 307.0 COG2223@1|root,COG2223@2|Bacteria,1MU27@1224|Proteobacteria,1RP5H@1236|Gammaproteobacteria,1XUSE@135623|Vibrionales 135623|Vibrionales P Major Facilitator Superfamily - - - ko:K02575 ko00910,map00910 M00615 - - ko00000,ko00001,ko00002,ko02000 2.A.1.8 - - MFS_1 k59_48015_2 945713.IALB_2543 8.59e-25 105.0 COG1766@1|root,COG1766@2|Bacteria 2|Bacteria N bacterial-type flagellum-dependent cell motility fliF - - ko:K02409 ko02040,map02040 - - - ko00000,ko00001,ko02035,ko02044 3.A.6.2,3.A.6.3 - - YscJ_FliF,YscJ_FliF_C k59_1456185_1 1279017.AQYJ01000021_gene2838 3.83e-72 234.0 COG0457@1|root,COG0457@2|Bacteria,1Q3YA@1224|Proteobacteria,1RN2D@1236|Gammaproteobacteria,46595@72275|Alteromonadaceae 1236|Gammaproteobacteria S Peptidase family M49 - - - - - - - - - - - - Peptidase_M49 k59_1456185_2 1045855.DSC_02250 4.59e-05 44.7 COG0302@1|root,COG0302@2|Bacteria,1MY3N@1224|Proteobacteria,1RMQM@1236|Gammaproteobacteria,1X3YF@135614|Xanthomonadales 135614|Xanthomonadales F GTP cyclohydrolase folE GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003933,GO:0003934,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006066,GO:0006725,GO:0006729,GO:0006732,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009108,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019238,GO:0019438,GO:0019751,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034311,GO:0034312,GO:0034641,GO:0035639,GO:0036094,GO:0042558,GO:0042559,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046146,GO:0046165,GO:0046173,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 3.5.4.16 ko:K01495 ko00790,ko01100,map00790,map01100 M00126,M00841,M00842,M00843 R00428,R04639,R05046,R05048 RC00263,RC00294,RC00323,RC00945,RC01188 ko00000,ko00001,ko00002,ko01000 - - - GTP_cyclohydroI k59_1405176_2 248742.XP_005646544.1 1.38e-68 227.0 COG2440@1|root,KOG2415@2759|Eukaryota,37HMK@33090|Viridiplantae,34KDA@3041|Chlorophyta 3041|Chlorophyta C Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S - - 1.5.5.1 ko:K00311 - - - - ko00000,ko01000 - - - ETF_QO,FAD_binding_2,NAD_binding_8 k59_388278_1 67281.JNZZ01000001_gene2066 7.51e-09 61.6 COG0673@1|root,COG0673@2|Bacteria 2|Bacteria S inositol 2-dehydrogenase activity rifL - - ko:K16015 ko01051,ko01130,map01051,map01130 - R06594 RC00182 ko00000,ko00001,ko01000 - - - GFO_IDH_MocA,GFO_IDH_MocA_C k59_1517734_1 1415779.JOMH01000001_gene1632 5.34e-57 203.0 COG0492@1|root,COG0664@1|root,COG1142@1|root,COG0492@2|Bacteria,COG0664@2|Bacteria,COG1142@2|Bacteria,1QWC6@1224|Proteobacteria,1RPDJ@1236|Gammaproteobacteria,1X4ZV@135614|Xanthomonadales 135614|Xanthomonadales COT 4Fe-4S dicluster domain - - - - - - - - - - - - Fer4_7,Pyr_redox_3,cNMP_binding k59_896777_1 279714.FuraDRAFT_2781 6.11e-52 178.0 COG3748@1|root,COG3748@2|Bacteria,1MWHB@1224|Proteobacteria,2VIC0@28216|Betaproteobacteria,2KSSD@206351|Neisseriales 206351|Neisseriales C Urate oxidase N-terminal - - - - - - - - - - - - Urate_ox_N k59_273675_1 1122137.AQXF01000001_gene2930 3.49e-128 371.0 COG0502@1|root,COG0502@2|Bacteria,1MVFF@1224|Proteobacteria,2TSD6@28211|Alphaproteobacteria 28211|Alphaproteobacteria H Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism bioB - 2.8.1.6 ko:K01012 ko00780,ko01100,map00780,map01100 M00123,M00573,M00577 R01078 RC00441 ko00000,ko00001,ko00002,ko01000 - - - BATS,Radical_SAM k59_273675_2 1122137.AQXF01000001_gene2929 9.23e-13 67.4 COG0161@1|root,COG0161@2|Bacteria,1MU2N@1224|Proteobacteria,2TQND@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family bioA - 2.6.1.62 ko:K00833 ko00780,ko01100,map00780,map01100 M00123,M00573,M00577 R03231 RC00006,RC00887 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 k59_1683218_2 926569.ANT_22320 2.17e-54 181.0 COG1559@1|root,COG1559@2|Bacteria,2G6G8@200795|Chloroflexi 200795|Chloroflexi S Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation mltG - - ko:K07082 - - - - ko00000 - - - YceG k59_1628968_1 196162.Noca_2614 1.44e-15 82.0 COG1316@1|root,COG1316@2|Bacteria,2GM55@201174|Actinobacteria,4DPV3@85009|Propionibacteriales 201174|Actinobacteria K cell envelope-related transcriptional attenuator - - - - - - - - - - - - LytR_cpsA_psr k59_1233055_1 1449353.JQMQ01000005_gene1404 1.27e-40 150.0 COG0318@1|root,COG0318@2|Bacteria,2GIUC@201174|Actinobacteria,2NM1P@228398|Streptacidiphilus 201174|Actinobacteria IQ AMP-binding enzyme C-terminal domain - - - - - - - - - - - - AMP-binding,AMP-binding_C k59_1233055_2 405948.SACE_3049 1.8e-09 58.9 COG1168@1|root,COG1168@2|Bacteria,2GJFQ@201174|Actinobacteria,4E1BH@85010|Pseudonocardiales 201174|Actinobacteria E Aminotransferase class I and II patB - 4.4.1.8 ko:K14155 ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230 - R00782,R01286,R02408,R04941 RC00056,RC00069,RC00382,RC00488,RC00710,RC01245,RC02303 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_1_2 k59_614543_2 582402.Hbal_2764 3.36e-165 496.0 COG1629@1|root,COG1629@2|Bacteria,COG4771@2|Bacteria,1MU9K@1224|Proteobacteria,2TTJG@28211|Alphaproteobacteria,43WD4@69657|Hyphomonadaceae 28211|Alphaproteobacteria P COG1629 Outer membrane receptor proteins, mostly Fe transport - - - - - - - - - - - - Plug,TonB_dep_Rec k59_837434_1 582402.Hbal_2753 1.24e-72 238.0 COG1554@1|root,COG1554@2|Bacteria,1QBJK@1224|Proteobacteria,2U2XK@28211|Alphaproteobacteria 28211|Alphaproteobacteria G hydrolase, family 65, central catalytic - - - - - - - - - - - - - k59_837434_2 582402.Hbal_2752 7.05e-42 146.0 COG3507@1|root,COG3507@2|Bacteria,1R10E@1224|Proteobacteria,2TYW2@28211|Alphaproteobacteria,43Z6H@69657|Hyphomonadaceae 28211|Alphaproteobacteria G Belongs to the glycosyl hydrolase 43 family - - - - - - - - - - - - Glyco_hydro_43 k59_777997_1 1380387.JADM01000019_gene3319 9.64e-57 184.0 COG1309@1|root,COG1309@2|Bacteria,1RDIM@1224|Proteobacteria,1S4DI@1236|Gammaproteobacteria 1236|Gammaproteobacteria K transcriptional regulator - - - - - - - - - - - - TetR_N k59_495838_1 143224.JQMD01000002_gene2339 4.21e-18 91.3 COG0508@1|root,COG0508@2|Bacteria,4NFB9@976|Bacteroidetes,1HZ6M@117743|Flavobacteriia 976|Bacteroidetes C The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) pdhC - 2.3.1.12 ko:K00627 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200 M00307 R00209,R02569 RC00004,RC02742,RC02857 br01601,ko00000,ko00001,ko00002,ko01000 - - - 2-oxoacid_dh,Biotin_lipoyl,E3_binding k59_1406284_1 398767.Glov_3260 5.01e-59 200.0 COG1884@1|root,COG2185@1|root,COG1884@2|Bacteria,COG2185@2|Bacteria,1MUXX@1224|Proteobacteria,42P03@68525|delta/epsilon subdivisions,2WIPY@28221|Deltaproteobacteria 28221|Deltaproteobacteria I Methylmalonyl-CoA mutase mutB - 5.4.99.2 ko:K01847 ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200 M00373,M00376,M00741 R00833 RC00395 ko00000,ko00001,ko00002,ko01000 - - - B12-binding,MM_CoA_mutase k59_495861_1 155864.EDL933_1926 4.03e-127 372.0 COG4932@1|root,COG4932@2|Bacteria,1QU9Z@1224|Proteobacteria,1T1R3@1236|Gammaproteobacteria,3XN7F@561|Escherichia 1236|Gammaproteobacteria M entry into host ychO GO:0005575,GO:0005623,GO:0008150,GO:0009279,GO:0009405,GO:0016020,GO:0019867,GO:0030260,GO:0030312,GO:0030313,GO:0031975,GO:0044403,GO:0044409,GO:0044419,GO:0044462,GO:0044464,GO:0051701,GO:0051704,GO:0051806,GO:0051828,GO:0071944 - ko:K13735 ko05100,map05100 - - - ko00000,ko00001 - - - IAT_beta k59_666762_1 1121921.KB898712_gene2175 7.12e-92 281.0 COG0006@1|root,COG0006@2|Bacteria,1MUZS@1224|Proteobacteria,1RN0W@1236|Gammaproteobacteria,2PMSG@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria E Aminopeptidase P, N-terminal domain pepP - 3.4.11.9 ko:K01262 - - - - ko00000,ko01000,ko01002 - - - AMP_N,Peptidase_M24 k59_1004246_1 876044.IMCC3088_481 3.3e-32 129.0 COG0591@1|root,COG4191@1|root,COG0591@2|Bacteria,COG4191@2|Bacteria,1QTSW@1224|Proteobacteria,1T1G2@1236|Gammaproteobacteria,1J4J9@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T PAS fold - - - - - - - - - - - - HATPase_c,HisKA,PAS_4,PAS_7,Response_reg,SSF k59_837468_1 113395.AXAI01000009_gene2589 3.89e-27 112.0 COG2984@1|root,COG2984@2|Bacteria,1MW5D@1224|Proteobacteria,2TSG1@28211|Alphaproteobacteria,3JSYZ@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S ABC transporter substrate binding protein - - - ko:K01989 - M00247 - - ko00000,ko00002,ko02000 - - - ABC_sub_bind k59_1684237_1 316407.85677005 3.71e-153 456.0 COG0525@1|root,COG0525@2|Bacteria,1MV7B@1224|Proteobacteria,1RNEB@1236|Gammaproteobacteria,3XMYC@561|Escherichia 1236|Gammaproteobacteria J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner valS GO:0000287,GO:0002161,GO:0003674,GO:0003824,GO:0004812,GO:0004832,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006417,GO:0006418,GO:0006438,GO:0006450,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0016070,GO:0016787,GO:0016788,GO:0016874,GO:0016875,GO:0019222,GO:0019538,GO:0019752,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0034248,GO:0034250,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045727,GO:0045903,GO:0046483,GO:0046872,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0052689,GO:0060255,GO:0061475,GO:0065007,GO:0065008,GO:0071704,GO:0080090,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:2000112 6.1.1.9 ko:K01873 ko00970,map00970 M00359,M00360 R03665 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iECH74115_1262.ECH74115_5779,iECNA114_1301.ECNA114_4481,iECO26_1355.ECO26_5428,iECSP_1301.ECSP_5359,iECs_1301.ECs5235,iG2583_1286.G2583_5088,iJN746.PP_0977,iSBO_1134.SBO_4182,iSSON_1240.SSON_4443,iYL1228.KPN_04663,iZ_1308.Z5870 Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1 k59_897868_1 301.JNHE01000006_gene1085 1.9e-91 293.0 COG3383@1|root,COG3383@2|Bacteria,1QTZB@1224|Proteobacteria,1T1JA@1236|Gammaproteobacteria,1YF5P@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria C NADH-ubiquinone oxidoreductase-G iron-sulfur binding region fdhF GO:0003674,GO:0003824,GO:0003954,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0008150,GO:0008152,GO:0009987,GO:0015942,GO:0015944,GO:0016491,GO:0016651,GO:0016999,GO:0017144,GO:0019752,GO:0030151,GO:0032787,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0071704 1.17.1.9,1.17.99.7 ko:K00123,ko:K22015 ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200 - R00519 RC02796 ko00000,ko00001,ko01000 - - iECBD_1354.ECBD_3953 Fer2_4,Fer4,Fer4_7,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3 k59_551449_1 349124.Hhal_0601 5.09e-98 307.0 COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,1RPCB@1236|Gammaproteobacteria,1WWYF@135613|Chromatiales 135613|Chromatiales O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner lon - 3.4.21.53 ko:K01338 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - AAA,LON_substr_bdg,Lon_C k59_389497_2 448385.sce8025 2.13e-20 86.7 COG0839@1|root,COG0839@2|Bacteria,1PJW9@1224|Proteobacteria,42V0F@68525|delta/epsilon subdivisions,2WS8G@28221|Deltaproteobacteria,2Z1CQ@29|Myxococcales 28221|Deltaproteobacteria C Belongs to the complex I subunit 6 family nuoJ - 1.6.5.3 ko:K00339 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q3 k59_727745_1 1280952.HJA_07012 2.65e-178 517.0 COG2132@1|root,COG2132@2|Bacteria,1MU0J@1224|Proteobacteria,2TQXH@28211|Alphaproteobacteria,43X7Y@69657|Hyphomonadaceae 28211|Alphaproteobacteria Q Copper-binding protein copA - - - - - - - - - - - Cu-oxidase,Cu-oxidase_2,Cu-oxidase_3 k59_1065578_1 1027273.GZ77_05530 1.19e-26 109.0 COG0845@1|root,COG0845@2|Bacteria,1R4JA@1224|Proteobacteria,1RPS5@1236|Gammaproteobacteria,1XJG3@135619|Oceanospirillales 135619|Oceanospirillales M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - - - - - - - - - - HlyD_D23 k59_274766_1 991905.SL003B_4266 2.06e-39 140.0 COG4122@1|root,COG4122@2|Bacteria,1MYYK@1224|Proteobacteria,2UADT@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Macrocin-O-methyltransferase (TylF) - - - - - - - - - - - - TylF k59_1684252_1 1026882.MAMP_00331 4.26e-82 261.0 COG0322@1|root,COG0322@2|Bacteria,1MV38@1224|Proteobacteria,1RNGV@1236|Gammaproteobacteria,45ZPV@72273|Thiotrichales 72273|Thiotrichales L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision uvrC - - ko:K03703 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - GIY-YIG,HHH_2,HHH_5,UVR,UvrC_HhH_N k59_389512_1 765911.Thivi_3037 4.62e-112 347.0 COG0471@1|root,COG0569@1|root,COG0471@2|Bacteria,COG0569@2|Bacteria,1MU0K@1224|Proteobacteria,1RMI1@1236|Gammaproteobacteria,1WXUN@135613|Chromatiales 135613|Chromatiales P TrkA-C domain - - - - - - - - - - - - CitMHS,TrkA_C k59_105116_2 1151061.CAJY01000028_gene791 5.91e-18 82.0 COG1189@1|root,COG1189@2|Bacteria,2GJVT@201174|Actinobacteria 201174|Actinobacteria J Ribosomal RNA methyltransferase RrmJ FtsJ tlyA GO:0000154,GO:0001510,GO:0001897,GO:0001906,GO:0001907,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0019835,GO:0019836,GO:0022613,GO:0031167,GO:0031640,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0035821,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044003,GO:0044004,GO:0044085,GO:0044179,GO:0044237,GO:0044238,GO:0044260,GO:0044364,GO:0044403,GO:0044419,GO:0044764,GO:0046483,GO:0051701,GO:0051704,GO:0051715,GO:0051801,GO:0051817,GO:0051818,GO:0051883,GO:0052331,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.226,2.1.1.227 ko:K06442 - - - - ko00000,ko01000,ko03009 - - - FtsJ,S4 k59_1793748_3 1229909.NSED_09720 9.18e-33 114.0 arCOG10511@1|root,arCOG10511@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_551468_1 109760.SPPG_02837T0 5.86e-78 247.0 COG0114@1|root,KOG1317@2759|Eukaryota,38GHX@33154|Opisthokonta,3NTY2@4751|Fungi 4751|Fungi C Fumarate hydratase - - 4.2.1.2 ko:K01679 ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04934,ko05200,ko05211,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200,map04934,map05200,map05211 M00009,M00011,M00173,M00376 R01082 RC00443 ko00000,ko00001,ko00002,ko01000 - - - FumaraseC_C,Lyase_1 k59_105121_1 697282.Mettu_3766 1.94e-58 198.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RRXX@1236|Gammaproteobacteria,1XDQM@135618|Methylococcales 135618|Methylococcales T Response regulator receiver - - - - - - - - - - - - HTH_8,Response_reg,Sigma54_activat k59_159536_1 1096930.L284_10005 5.75e-41 139.0 COG2852@1|root,COG2852@2|Bacteria 2|Bacteria L Protein conserved in bacteria trmJ - - ko:K02533 - - - - ko00000,ko01000,ko03016 - - - DUF559,SpoU_methylase k59_159536_2 1144305.PMI02_05266 1.38e-50 172.0 COG0719@1|root,COG0719@2|Bacteria,1MVKY@1224|Proteobacteria,2TRU6@28211|Alphaproteobacteria,2K196@204457|Sphingomonadales 204457|Sphingomonadales O ABC-type transport system involved in Fe-S cluster assembly, permease component sufB - - ko:K09014 - - - - ko00000 - - - UPF0051 k59_274773_1 82996.sch_17500 0.000291 43.5 COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,1RMFF@1236|Gammaproteobacteria,402DM@613|Serratia 1236|Gammaproteobacteria C E3 component of pyruvate and 2-oxoglutarate dehydrogenase complex - - 1.8.1.4 ko:K00382 ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00036,M00307,M00532 R00209,R01221,R01698,R03815,R07618,R08549 RC00004,RC00022,RC00583,RC02742,RC02833,RC02834 br01601,ko00000,ko00001,ko00002,ko01000,ko04147 - - - Pyr_redox_2,Pyr_redox_dim k59_274773_2 644548.SCNU_06155 2.69e-23 103.0 COG0508@1|root,COG0508@2|Bacteria,2GMUV@201174|Actinobacteria,4GARX@85026|Gordoniaceae 201174|Actinobacteria C e3 binding domain sucB - 2.3.1.61 ko:K00658 ko00020,ko00310,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00032 R02570,R02571,R08549 RC00004,RC02727,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - 2-oxoacid_dh,Biotin_lipoyl,E3_binding k59_614589_1 633149.Bresu_2582 1.02e-18 94.0 COG1452@1|root,COG1452@2|Bacteria,1MUJC@1224|Proteobacteria,2TR3B@28211|Alphaproteobacteria,2KF85@204458|Caulobacterales 204458|Caulobacterales M Involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane lptD - - ko:K04744 - - - - ko00000,ko02000 1.B.42.1 - - OstA_C k59_1406332_2 1158318.ATXC01000001_gene910 8.03e-40 140.0 COG0698@1|root,COG0698@2|Bacteria,2G43P@200783|Aquificae 200783|Aquificae G ribose 5-phosphate isomerase B rpiB - 5.3.1.6 ko:K01808 ko00030,ko00051,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00051,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01056,R09030 RC00376,RC00434 ko00000,ko00001,ko00002,ko01000 - - - LacAB_rpiB k59_440449_1 436308.Nmar_0602 5.64e-14 66.6 arCOG08744@1|root,arCOG08744@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_274787_1 751994.AGIG01000010_gene1035 5.51e-25 99.0 COG1539@1|root,COG1539@2|Bacteria,1RDHQ@1224|Proteobacteria,1S4Q3@1236|Gammaproteobacteria 1236|Gammaproteobacteria H Catalyzes the formation of dihydromonapterin triphosphate from dihydroneopterin triphosphate folX GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0008719,GO:0009987,GO:0016853,GO:0019752,GO:0034641,GO:0042558,GO:0043436,GO:0043603,GO:0044237,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051186,GO:0071704,GO:1901360,GO:1901564 5.1.99.7 ko:K07589 ko00790,map00790 - R11082 RC01479 ko00000,ko00001,ko01000 - - - FolB k59_274787_2 710686.Mycsm_05330 9.02e-19 89.4 COG1028@1|root,COG1028@2|Bacteria,2GJU1@201174|Actinobacteria,232EM@1762|Mycobacteriaceae 201174|Actinobacteria IQ Dehydrogenase hdhA GO:0002682,GO:0002684,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0009605,GO:0009607,GO:0016020,GO:0035821,GO:0043207,GO:0044003,GO:0044403,GO:0044419,GO:0044464,GO:0048518,GO:0048583,GO:0048584,GO:0050776,GO:0050778,GO:0050789,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0051817,GO:0052031,GO:0052173,GO:0052200,GO:0052255,GO:0052552,GO:0052553,GO:0052555,GO:0052556,GO:0052564,GO:0052572,GO:0065007,GO:0071944,GO:0075136 1.1.1.159 ko:K00076 ko00121,map00121 - - - ko00000,ko00001,ko01000 - - - adh_short_C2 k59_1233114_2 1229909.NSED_01090 2e-114 339.0 COG0124@1|root,arCOG00404@2157|Archaea,41S9T@651137|Thaumarchaeota 651137|Thaumarchaeota J histidyl-tRNA synthetase - - 6.1.1.21 ko:K01892 ko00970,map00970 M00359,M00360 R03655 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,tRNA-synt_His k59_1065592_1 1347342.BN863_19710 9.88e-95 293.0 COG3387@1|root,COG3387@2|Bacteria,4NEE6@976|Bacteroidetes,1HY70@117743|Flavobacteriia 976|Bacteroidetes G COG3387 Glucoamylase and related glycosyl - - 3.2.1.3 ko:K01178 ko00500,ko01100,map00500,map01100 - R01790,R01791,R06199 - ko00000,ko00001,ko01000 - GH15 - Glyco_hydro_15 k59_727795_1 1229909.NSED_09935 4.22e-59 192.0 COG5491@1|root,arCOG00452@2157|Archaea,41SJ3@651137|Thaumarchaeota 651137|Thaumarchaeota D conserved protein implicated in secretion - - - - - - - - - - - - - k59_666817_1 648757.Rvan_2516 2.01e-25 107.0 COG1629@1|root,COG4771@2|Bacteria,1MX42@1224|Proteobacteria,2TR9M@28211|Alphaproteobacteria,3N6WA@45401|Hyphomicrobiaceae 28211|Alphaproteobacteria P TonB dependent receptor - - - ko:K16087 - - - - ko00000,ko02000 1.B.14.2 - - Plug,TonB_dep_Rec k59_159559_1 396588.Tgr7_2275 5.04e-48 161.0 COG1057@1|root,COG1057@2|Bacteria,1RD0J@1224|Proteobacteria,1RP00@1236|Gammaproteobacteria,1WY6R@135613|Chromatiales 135613|Chromatiales H Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) nadD - 2.7.7.18 ko:K00969 ko00760,ko01100,map00760,map01100 M00115 R00137,R03005 RC00002 ko00000,ko00001,ko00002,ko01000 - - - CTP_transf_like k59_1233121_5 613026.HRAG_01647 3.82e-05 49.7 COG3723@1|root,COG3723@2|Bacteria,1R6DB@1224|Proteobacteria,42MDQ@68525|delta/epsilon subdivisions,2YN45@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L RecT family - - - ko:K07455 - - - - ko00000,ko03400 - - - RecT k59_216784_2 1122164.JHWF01000025_gene68 2.27e-76 251.0 COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,1RMZ8@1236|Gammaproteobacteria,1JCH1@118969|Legionellales 118969|Legionellales I 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain yfcX - 1.1.1.35,4.2.1.17,5.1.2.3 ko:K01782 ko00071,ko00280,ko00281,ko00310,ko00362,ko00380,ko00410,ko00640,ko00650,ko00903,ko00930,ko01040,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00362,map00380,map00410,map00640,map00650,map00903,map00930,map01040,map01100,map01110,map01120,map01130,map01200,map01212 M00032,M00087 R01975,R03026,R03045,R03276,R04137,R04170,R04203,R04204,R04224,R04737,R04738,R04739,R04740,R04741,R04744,R04745,R04746,R04748,R04749,R05066,R05305,R06411,R06412,R06941,R06942,R07935,R07951,R08093,R08094 RC00029,RC00099,RC00117,RC00241,RC00525,RC00831,RC00834,RC00896,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 - - - 3HCDH,3HCDH_N,ECH_1 k59_440478_1 178901.AmDm5_2337 2.25e-70 234.0 COG3591@1|root,COG3591@2|Bacteria,1MX71@1224|Proteobacteria,2U2MN@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Peptidase S46 - - - - - - - - - - - - Peptidase_S46 k59_1287642_1 1229909.NSED_06120 6.26e-60 187.0 arCOG08726@1|root,arCOG08726@2157|Archaea,41STN@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1287642_2 436308.Nmar_1039 3.57e-40 136.0 COG1676@1|root,arCOG01701@2157|Archaea,41SHW@651137|Thaumarchaeota 651137|Thaumarchaeota L tRNA intron endonuclease, N-terminal domain - - 4.6.1.16 ko:K01170 - - - - ko00000,ko01000,ko03016 - - - tRNA_int_endo,tRNA_int_endo_N k59_440485_2 1123037.AUDE01000021_gene2202 1.57e-42 151.0 COG3291@1|root,COG3291@2|Bacteria,4PKU5@976|Bacteroidetes,1IJEZ@117743|Flavobacteriia 976|Bacteroidetes S Pkd domain containing protein - - - - - - - - - - - - - k59_1004316_1 392499.Swit_0921 2.51e-54 195.0 COG4773@1|root,COG4773@2|Bacteria,1R4DT@1224|Proteobacteria,2TYEM@28211|Alphaproteobacteria,2KEKY@204457|Sphingomonadales 204457|Sphingomonadales P TonB dependent receptor - - - - - - - - - - - - Plug,TonB_dep_Rec k59_1793790_1 876044.IMCC3088_635 3.11e-136 397.0 COG2801@1|root,COG2963@1|root,COG2801@2|Bacteria,COG2963@2|Bacteria,1MWNX@1224|Proteobacteria,1RQHG@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Integrase catalytic - - - - - - - - - - - - HTH_23,LZ_Tnp_IS481,rve k59_778105_1 1177154.Y5S_02570 4.52e-83 258.0 COG0389@1|root,COG0389@2|Bacteria,1MUUH@1224|Proteobacteria,1RMT1@1236|Gammaproteobacteria,1XH3E@135619|Oceanospirillales 135619|Oceanospirillales L DNA polymerase umuC - - ko:K03502 - - - - ko00000,ko03400 - - - DUF4113,IMS,IMS_C,IMS_HHH k59_159565_1 1163617.SCD_n01950 7.94e-29 119.0 COG3164@1|root,COG3164@2|Bacteria,1MXWF@1224|Proteobacteria,2VH52@28216|Betaproteobacteria 28216|Betaproteobacteria S Protein of unknown function - - - - - - - - - - - - AsmA_2,DUF3971 k59_1406393_1 644282.Deba_1216 5.01e-22 94.7 COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria,42MFK@68525|delta/epsilon subdivisions,2WKBU@28221|Deltaproteobacteria 28221|Deltaproteobacteria E extracellular solute-binding protein, family 5 - - - ko:K02035,ko:K13893 ko02010,ko02024,map02010,map02024 M00239,M00349 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5,3.A.1.5.21,3.A.1.5.24 - - SBP_bac_5 k59_1406393_2 768670.Calni_0861 8.49e-31 119.0 COG0601@1|root,COG0601@2|Bacteria,2GF8S@200930|Deferribacteres 200930|Deferribacteres P Binding-protein-dependent transport system inner membrane component - - - ko:K02033 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1 k59_495947_1 316407.85676473 8.4e-13 66.2 COG2992@1|root,COG2992@2|Bacteria,1RD3U@1224|Proteobacteria,1S3RA@1236|Gammaproteobacteria,3XN6F@561|Escherichia 1236|Gammaproteobacteria S amidase activity bax - - ko:K03796 - - - - ko00000 - GH73 - Glucosaminidase k59_495947_2 316407.85676474 2.85e-49 166.0 COG1609@1|root,COG2207@1|root,COG1609@2|Bacteria,COG2207@2|Bacteria,1NYTD@1224|Proteobacteria,1RNGZ@1236|Gammaproteobacteria,3XN8D@561|Escherichia 1236|Gammaproteobacteria K Regulatory protein for the xylBAFGHR operon xylR GO:0003674,GO:0003700,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0140110,GO:1903506,GO:2000112,GO:2001141 - ko:K02529 - - - - ko00000,ko03000 - - - HTH_18,HTH_AraC,Peripla_BP_3 k59_1692912_1 247634.GPB2148_3218 2.85e-20 93.6 COG2141@1|root,COG2141@2|Bacteria,1MXZH@1224|Proteobacteria,1RMB2@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Catalyzes the pyrimidine ring opening between N-3 and C- 4 by an unusual flavin hydroperoxide-catalyzed mechanism to yield ureidoacrylate peracid. It cleaves pyrmidine rings directly by adding oxygen atoms, making a toxic ureidoacrylate peracid product which can be spontaneously reduced to ureidoacrylate rutA GO:0003674,GO:0003824,GO:0004497,GO:0006139,GO:0006206,GO:0006208,GO:0006210,GO:0006212,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009112,GO:0009987,GO:0016491,GO:0017144,GO:0019740,GO:0019859,GO:0019860,GO:0034641,GO:0042737,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0046113,GO:0046483,GO:0046700,GO:0052614,GO:0055086,GO:0055114,GO:0071704,GO:0072527,GO:0072529,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575 1.14.99.46 ko:K09018 ko00240,ko01100,map00240,map01100 - R09936 RC02732 ko00000,ko00001,ko01000 - - iEC55989_1330.EC55989_1123,iECUMN_1333.ECUMN_1195 Bac_luciferase k59_1692912_2 1120949.KB903294_gene3647 4.72e-09 57.0 COG3662@1|root,COG3662@2|Bacteria,2GNTU@201174|Actinobacteria 201174|Actinobacteria S protein conserved in bacteria - - - - - - - - - - - - DUF2236 k59_1352111_1 565045.NOR51B_2939 1.49e-06 48.1 COG5405@1|root,COG5405@2|Bacteria,1MVF2@1224|Proteobacteria,1RP7P@1236|Gammaproteobacteria 1236|Gammaproteobacteria O Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery hslV GO:0000166,GO:0000287,GO:0000502,GO:0003674,GO:0003824,GO:0004175,GO:0004298,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009266,GO:0009376,GO:0009408,GO:0009628,GO:0009987,GO:0016043,GO:0016787,GO:0017076,GO:0019538,GO:0019904,GO:0022607,GO:0030163,GO:0030554,GO:0031597,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0034214,GO:0035639,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046872,GO:0050896,GO:0051259,GO:0051603,GO:0065003,GO:0070003,GO:0070011,GO:0071704,GO:0071840,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1904949,GO:1905368,GO:1905369 3.4.25.2 ko:K01419 - - - - ko00000,ko01000,ko01002 - - - Proteasome k59_1352111_2 1036674.A28LD_1171 9.74e-66 213.0 COG1220@1|root,COG1220@2|Bacteria,1MVK9@1224|Proteobacteria,1RMYV@1236|Gammaproteobacteria,2QF9V@267893|Idiomarinaceae 1236|Gammaproteobacteria O this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis hslU GO:0000166,GO:0000287,GO:0000502,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009266,GO:0009376,GO:0009408,GO:0009628,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0019904,GO:0022607,GO:0030554,GO:0031597,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0034214,GO:0035639,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043335,GO:0043933,GO:0044085,GO:0044238,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046872,GO:0050896,GO:0051259,GO:0065003,GO:0071704,GO:0071840,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1902494,GO:1904949,GO:1905368,GO:1905369 - ko:K03667 - - - - ko00000,ko03110 - - - AAA_2,ClpB_D2-small k59_1185382_1 1122137.AQXF01000004_gene1631 1.13e-31 122.0 COG0845@1|root,COG0845@2|Bacteria,1PEVY@1224|Proteobacteria 1224|Proteobacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - - - - - - - - - - Biotin_lipoyl_2,HlyD_3 k59_786501_1 1380387.JADM01000008_gene915 2.53e-50 176.0 COG1752@1|root,COG1752@2|Bacteria,1N5SK@1224|Proteobacteria,1RSDG@1236|Gammaproteobacteria,1XNVN@135619|Oceanospirillales 135619|Oceanospirillales S esterase of the alpha-beta hydrolase superfamily - - - ko:K07001 - - - - ko00000 - - - DUF3336,Patatin k59_846216_1 946077.W5A_09254 5.51e-105 320.0 COG3525@1|root,COG3525@2|Bacteria,4NE08@976|Bacteroidetes,1HXU1@117743|Flavobacteriia 976|Bacteroidetes G Glycosyl hydrolase family 20, catalytic domain - - 3.2.1.52 ko:K12373 ko00511,ko00513,ko00520,ko00531,ko00603,ko00604,ko01100,ko04142,map00511,map00513,map00520,map00531,map00603,map00604,map01100,map04142 M00079 R00022,R06004,R11316 RC00049 ko00000,ko00001,ko00002,ko01000,ko03110 - GH20 - CHB_HEX_C_1,F5_F8_type_C,Fn3_assoc,Glyco_hydro_20,Glyco_hydro_20b k59_1185388_1 983920.Y88_1236 1.03e-94 284.0 COG1187@1|root,COG1187@2|Bacteria,1MUCE@1224|Proteobacteria,2TQP2@28211|Alphaproteobacteria,2K0YS@204457|Sphingomonadales 204457|Sphingomonadales J Belongs to the pseudouridine synthase RsuA family rluB - 5.4.99.22 ko:K06178 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2,S4 k59_1296123_1 887898.HMPREF0551_0426 5.03e-41 146.0 COG1488@1|root,COG1488@2|Bacteria,1MV8U@1224|Proteobacteria,2VGZ5@28216|Betaproteobacteria,1K2JW@119060|Burkholderiaceae 28216|Betaproteobacteria F Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP pncB GO:0000183,GO:0001302,GO:0003674,GO:0003824,GO:0004516,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0006139,GO:0006325,GO:0006342,GO:0006348,GO:0006355,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006996,GO:0007568,GO:0007569,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016043,GO:0016458,GO:0016874,GO:0016879,GO:0018130,GO:0019219,GO:0019222,GO:0019357,GO:0019358,GO:0019362,GO:0019363,GO:0019365,GO:0019438,GO:0019637,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032502,GO:0034641,GO:0034654,GO:0040029,GO:0043094,GO:0043173,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0045814,GO:0045892,GO:0045934,GO:0046483,GO:0046497,GO:0048519,GO:0048523,GO:0048869,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051186,GO:0051188,GO:0051252,GO:0051253,GO:0051276,GO:0055086,GO:0060255,GO:0065007,GO:0071704,GO:0071840,GO:0072524,GO:0072525,GO:0080090,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 6.3.4.21 ko:K00763 ko00760,ko01100,map00760,map01100 - R01724 RC00033 ko00000,ko00001,ko01000 - - - NAPRTase k59_1692956_1 1122137.AQXF01000002_gene289 3.11e-89 270.0 COG0715@1|root,COG0715@2|Bacteria,1MXA3@1224|Proteobacteria,2TTW8@28211|Alphaproteobacteria 28211|Alphaproteobacteria P ABC transporter substrate-binding protein MA20_40330 - - ko:K02051 - M00188 - - ko00000,ko00002,ko02000 3.A.1.16,3.A.1.17 - - NMT1 k59_957058_1 745411.B3C1_14058 1.18e-122 374.0 COG0358@1|root,COG0358@2|Bacteria,1MUHC@1224|Proteobacteria,1RMGA@1236|Gammaproteobacteria,1J4QZ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication dnaG GO:0003674,GO:0003824,GO:0003896,GO:0003899,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006269,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576 - ko:K02316 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB_bind,DnaG_DnaB_bind,Toprim_2,Toprim_4,Toprim_N,zf-CHC2 k59_448799_1 1323663.AROI01000005_gene3086 7.01e-43 158.0 COG3119@1|root,COG3119@2|Bacteria,1MV0B@1224|Proteobacteria,1RRY3@1236|Gammaproteobacteria 1236|Gammaproteobacteria P Sulfatase - - 3.1.6.6 ko:K01133 - - - - ko00000,ko01000 - - - DUF4976,Sulfatase k59_448799_2 1280944.HY17_06015 2.97e-51 169.0 COG1309@1|root,COG1309@2|Bacteria,1R7F8@1224|Proteobacteria,2U0DG@28211|Alphaproteobacteria,43YV2@69657|Hyphomonadaceae 28211|Alphaproteobacteria K Bacterial regulatory proteins, tetR family - - - - - - - - - - - - TetR_N k59_1692962_1 1144307.PMI04_03276 1.15e-90 278.0 COG1960@1|root,COG1960@2|Bacteria,1Q2YE@1224|Proteobacteria,2TSY2@28211|Alphaproteobacteria,2K2KK@204457|Sphingomonadales 204457|Sphingomonadales I Acyl-CoA dehydrogenase, middle domain - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_504069_2 1096930.L284_05310 1.98e-54 184.0 COG1766@1|root,COG1766@2|Bacteria,1MUQR@1224|Proteobacteria,2TR6J@28211|Alphaproteobacteria,2K025@204457|Sphingomonadales 204457|Sphingomonadales N The M ring may be actively involved in energy transduction - - - ko:K02409 ko02040,map02040 - - - ko00000,ko00001,ko02035,ko02044 3.A.6.2,3.A.6.3 - - YscJ_FliF,YscJ_FliF_C k59_1637527_1 1120963.KB894527_gene598 2.07e-17 75.1 2EKPQ@1|root,33EDG@2|Bacteria,1NMRQ@1224|Proteobacteria,1SHHI@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_1241471_1 316407.85675321 6.44e-176 525.0 COG3468@1|root,COG3468@2|Bacteria,1R9B8@1224|Proteobacteria,1S1YA@1236|Gammaproteobacteria,3XQFF@561|Escherichia 1236|Gammaproteobacteria MU cell adhesion involved in single-species biofilm formation yfaL GO:0005575,GO:0005576,GO:0005623,GO:0007155,GO:0008150,GO:0009314,GO:0009411,GO:0009416,GO:0009628,GO:0009986,GO:0009987,GO:0022610,GO:0031589,GO:0042597,GO:0042710,GO:0043708,GO:0043709,GO:0044010,GO:0044464,GO:0044764,GO:0050896,GO:0051704,GO:0090605,GO:0090609 - ko:K07279 - - - - ko00000,ko02000,ko02044 1.B.12 - - Autotransporter,Chlam_PMP,PATR,Pertactin k59_1465752_1 1163409.UUA_08351 2.16e-84 268.0 COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,1MWGR@1224|Proteobacteria,1RR88@1236|Gammaproteobacteria,1X51Q@135614|Xanthomonadales 135614|Xanthomonadales EU Prolyl oligopeptidase family - - - - - - - - - - - - PD40,Peptidase_S9 k59_1465752_2 1122137.AQXF01000003_gene2092 2.09e-56 188.0 COG0531@1|root,COG0531@2|Bacteria,1MXNJ@1224|Proteobacteria 1224|Proteobacteria E amino acid - - - - - - - - - - - - AA_permease_2,PTS_EIIA_2,TrkA_C k59_1126957_1 1392490.JHZX01000001_gene1923 7.89e-81 273.0 COG3291@1|root,COG3291@2|Bacteria 2|Bacteria S metallopeptidase activity - - - - - - - - - - - - CHU_C,CUB,Cleaved_Adhesin,MAM,PKD,fn3 k59_1241500_1 1519464.HY22_13990 6.37e-21 92.4 28KU8@1|root,2ZCM9@2|Bacteria 2|Bacteria S STELLO glycosyltransferases - - - - - - - - - - - - STELLO k59_1241500_2 1384049.CD29_16200 3.31e-09 60.8 COG0451@1|root,COG0451@2|Bacteria,1V34Y@1239|Firmicutes,4HCJE@91061|Bacilli,3J09N@400634|Lysinibacillus 91061|Bacilli GM Male sterility protein - - 5.1.3.2 ko:K01784 ko00052,ko00520,ko01100,map00052,map00520,map01100 M00361,M00362,M00632 R00291,R02984 RC00289 ko00000,ko00001,ko00002,ko01000 - - - Epimerase,GAF_3,GDP_Man_Dehyd k59_225302_1 1122201.AUAZ01000012_gene1335 8.67e-83 265.0 COG0768@1|root,COG0768@2|Bacteria,1MV8C@1224|Proteobacteria,1RN9H@1236|Gammaproteobacteria,464KX@72275|Alteromonadaceae 1236|Gammaproteobacteria M Catalyzes cross-linking of the peptidoglycan cell wall mrdA GO:0000270,GO:0003674,GO:0003824,GO:0004180,GO:0004185,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006022,GO:0006023,GO:0006024,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0008238,GO:0008360,GO:0008658,GO:0009002,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016021,GO:0016043,GO:0016787,GO:0017171,GO:0019538,GO:0022603,GO:0022604,GO:0030203,GO:0031224,GO:0031226,GO:0031406,GO:0033218,GO:0033293,GO:0034645,GO:0036094,GO:0042221,GO:0042493,GO:0042546,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044425,GO:0044459,GO:0044464,GO:0045229,GO:0046677,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051128,GO:0065007,GO:0065008,GO:0070008,GO:0070011,GO:0070589,GO:0071554,GO:0071555,GO:0071704,GO:0071840,GO:0071944,GO:0071972,GO:0097159,GO:0140096,GO:1901135,GO:1901137,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901681 3.4.16.4 ko:K05515 ko00550,ko01501,map00550,map01501 - - - ko00000,ko00001,ko01000,ko01011 - - iEcE24377_1341.EcE24377A_0661,iPC815.YPO2604 PBP_dimer,Transpeptidase k59_786567_1 640081.Dsui_2996 1.42e-25 106.0 COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,2VHQ1@28216|Betaproteobacteria,2KV9Y@206389|Rhodocyclales 206389|Rhodocyclales NU Type II secretion system (T2SS), protein E, N-terminal domain - - - ko:K02454 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - T2SSE,T2SSE_N k59_786567_2 391615.ABSJ01000037_gene831 5.17e-31 117.0 2B96M@1|root,322HU@2|Bacteria,1RIIU@1224|Proteobacteria,1SPF2@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_1352182_1 394221.Mmar10_0204 4.93e-49 167.0 COG3182@1|root,COG3182@2|Bacteria,1R59B@1224|Proteobacteria,2U2XT@28211|Alphaproteobacteria,43Y0K@69657|Hyphomonadaceae 28211|Alphaproteobacteria S conserved secreted or membrane protein precursor - - - - - - - - - - - - PepSY_TM k59_1749783_1 622637.KE124774_gene3643 1.67e-18 84.7 28I9W@1|root,2Z8CH@2|Bacteria,1QCN6@1224|Proteobacteria,2U1GU@28211|Alphaproteobacteria,36Z6Y@31993|Methylocystaceae 28211|Alphaproteobacteria S SIR2-like domain - - - - - - - - - - - - SIR2_2 k59_1749783_3 1126627.BAWE01000005_gene5968 3.62e-96 293.0 COG0399@1|root,COG0399@2|Bacteria,1MUPN@1224|Proteobacteria,2TRIQ@28211|Alphaproteobacteria,3JSRK@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria E Belongs to the DegT DnrJ EryC1 family - - 2.6.1.102 ko:K13010 ko00520,map00520 - R10460 RC00006,RC00781 ko00000,ko00001,ko01000,ko01005,ko01007 - - - DegT_DnrJ_EryC1 k59_1637592_1 545264.KB898745_gene1204 4.13e-38 140.0 COG0460@1|root,COG0460@2|Bacteria,1MUDC@1224|Proteobacteria,1RPEU@1236|Gammaproteobacteria,1WWHB@135613|Chromatiales 135613|Chromatiales E homoserine dehydrogenase - - 1.1.1.3 ko:K00003 ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230 M00017,M00018 R01773,R01775 RC00087 ko00000,ko00001,ko00002,ko01000 - - - ACT,Homoserine_dh,NAD_binding_3 k59_1637592_2 1122951.ATUE01000008_gene204 9.8e-39 139.0 COG0498@1|root,COG0498@2|Bacteria,1MUWQ@1224|Proteobacteria,1RQ0H@1236|Gammaproteobacteria,3NIF7@468|Moraxellaceae 1236|Gammaproteobacteria E Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine thrC GO:0003674,GO:0003824,GO:0004795,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006566,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009088,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016838,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.2.3.1 ko:K01733 ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230 M00018 R01466,R05086 RC00017,RC00526 ko00000,ko00001,ko00002,ko01000 - - iLF82_1304.LF82_2261,iNRG857_1313.NRG857_00025 PALP,Thr_synth_N k59_225354_1 452662.SJA_C1-00130 1.12e-09 57.8 COG0325@1|root,COG0325@2|Bacteria,1MWN7@1224|Proteobacteria,2TR5Z@28211|Alphaproteobacteria,2K0C6@204457|Sphingomonadales 204457|Sphingomonadales S Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis - - - ko:K06997 - - - - ko00000 - - - Ala_racemase_N k59_225354_2 555793.WSK_2178 2.29e-48 161.0 COG1280@1|root,COG1280@2|Bacteria,1MXAI@1224|Proteobacteria,2U8MN@28211|Alphaproteobacteria,2KCSI@204457|Sphingomonadales 204457|Sphingomonadales E threonine efflux protein - - - - - - - - - - - - LysE k59_448861_1 1459636.NTE_02391 2.2e-31 118.0 COG0677@1|root,arCOG00252@2157|Archaea 2157|Archaea M Belongs to the UDP-glucose GDP-mannose dehydrogenase family - - 1.1.1.336 ko:K02472 ko00520,ko05111,map00520,map05111 - R03317 RC00291 ko00000,ko00001,ko01000 - - - NAD_binding_2,UDPG_MGDP_dh,UDPG_MGDP_dh_C k59_1749799_1 491952.Mar181_2716 3.32e-107 319.0 COG1186@1|root,COG1186@2|Bacteria,1MUAW@1224|Proteobacteria,1RP9Z@1236|Gammaproteobacteria,1XHPA@135619|Oceanospirillales 135619|Oceanospirillales J Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA prfB - - ko:K02836 - - - - ko00000,ko03012 - - - PCRF,RF-1 k59_1241562_2 379731.PST_2975 2.03e-46 158.0 COG1968@1|root,COG1968@2|Bacteria,1MX02@1224|Proteobacteria,1RQQT@1236|Gammaproteobacteria,1Z1FE@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria V Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin uppP - 3.6.1.27 ko:K06153 ko00550,map00550 - R05627 RC00002 ko00000,ko00001,ko01000,ko01011 - - - BacA k59_1012550_1 398580.Dshi_1551 9.63e-44 152.0 COG0757@1|root,COG0757@2|Bacteria,1RDDT@1224|Proteobacteria,2U9BV@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Catalyzes a trans-dehydration via an enolate intermediate aroQ - 4.2.1.10 ko:K03786 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R03084 RC00848 ko00000,ko00001,ko00002,ko01000 - - - DHquinase_II k59_957186_1 591158.SSMG_01130 2.63e-25 109.0 COG2141@1|root,COG2141@2|Bacteria,2GMUE@201174|Actinobacteria 201174|Actinobacteria C Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - - - - - - - - - - Bac_luciferase k59_1012557_2 68260.JOAY01000019_gene1559 6.38e-72 228.0 COG1526@1|root,COG1526@2|Bacteria,2GKWC@201174|Actinobacteria 201174|Actinobacteria C Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH fdhD - - ko:K02379 - - - - ko00000 - - - FdhD-NarQ k59_1185494_1 479435.Kfla_6312 2.16e-16 80.9 COG0318@1|root,COG0318@2|Bacteria,2GN9C@201174|Actinobacteria,4DP67@85009|Propionibacteriales 201174|Actinobacteria IQ AMP-binding enzyme menE GO:0003674,GO:0003824,GO:0008150,GO:0008756,GO:0016405,GO:0016874,GO:0016877,GO:0016878,GO:0040007 4.2.1.113,6.2.1.26 ko:K01911,ko:K02549 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116 R04030,R04031 RC00004,RC00014,RC01053 ko00000,ko00001,ko00002,ko01000 - - - AMP-binding,AMP-binding_C k59_1185494_2 561175.KB894097_gene60 1.58e-08 56.2 COG1028@1|root,COG1028@2|Bacteria,2GMEH@201174|Actinobacteria,4EJIT@85012|Streptosporangiales 201174|Actinobacteria IQ Enoyl-(Acyl carrier protein) reductase - - 1.1.1.100 ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 k59_957196_1 279714.FuraDRAFT_3903 4.06e-14 68.2 2DQ77@1|root,3351E@2|Bacteria,1N9D8@1224|Proteobacteria,2VVUI@28216|Betaproteobacteria,2KRWH@206351|Neisseriales 206351|Neisseriales - - - - - - - - - - - - - - - k59_957196_2 580332.Slit_0452 9.93e-66 213.0 COG1752@1|root,COG1752@2|Bacteria,1PIHH@1224|Proteobacteria,2VHKX@28216|Betaproteobacteria 28216|Betaproteobacteria S Esterase of the alpha-beta hydrolase superfamily - - - ko:K07001 - - - - ko00000 - - - Patatin k59_1296235_1 745411.B3C1_09597 1.07e-45 159.0 COG1215@1|root,COG1215@2|Bacteria,1MWH9@1224|Proteobacteria,1RPTN@1236|Gammaproteobacteria,1J4WS@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M COG0463 Glycosyltransferases involved in cell wall biogenesis - - 2.4.1.266 ko:K13693 - - - - ko00000,ko01000,ko01003 - GT81 - - k59_846321_2 42565.FP66_15220 8.39e-57 183.0 COG2227@1|root,COG2227@2|Bacteria,1MU89@1224|Proteobacteria,1RMV7@1236|Gammaproteobacteria,1XH4S@135619|Oceanospirillales 135619|Oceanospirillales H O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway ubiG - 2.1.1.222,2.1.1.64 ko:K00568 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00117 R04988,R05614,R08769,R08781 RC00003,RC00392,RC01895 ko00000,ko00001,ko00002,ko01000 - - - Methyltransf_23 k59_675090_1 99598.Cal7507_0788 8.98e-52 192.0 COG0531@1|root,COG4191@1|root,COG0531@2|Bacteria,COG4191@2|Bacteria,1GITJ@1117|Cyanobacteria,1HINB@1161|Nostocales 1117|Cyanobacteria T PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - AA_permease_2,HATPase_c,HisKA,PAS k59_1296249_1 391615.ABSJ01000039_gene1861 2.19e-08 53.9 COG1192@1|root,COG1192@2|Bacteria,1QBJX@1224|Proteobacteria,1S739@1236|Gammaproteobacteria,1J6UB@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria D AAA domain - - - ko:K03496 - - - - ko00000,ko03036,ko04812 - - - AAA_31,CbiA k59_1127072_1 1122137.AQXF01000004_gene1650 1.13e-50 180.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,2TQR7@28211|Alphaproteobacteria 28211|Alphaproteobacteria T methyl-accepting chemotaxis protein - - - - - - - - - - - - MCPsignal k59_1296259_1 1122137.AQXF01000001_gene3280 3.07e-26 101.0 COG5468@1|root,COG5468@2|Bacteria 2|Bacteria S Lipopolysaccharide-assembly - - - ko:K03643 - - - - ko00000,ko02000 1.B.42.1 - - LptE k59_1296259_2 1122137.AQXF01000001_gene3281 2.39e-69 219.0 COG1466@1|root,COG1466@2|Bacteria,1R8PA@1224|Proteobacteria,2U1KQ@28211|Alphaproteobacteria 28211|Alphaproteobacteria L DNA polymerase III delta subunit holA - 2.7.7.7 ko:K02340 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_delta k59_1802253_1 155864.EDL933_4999 2.23e-16 70.9 2C84E@1|root,30MF8@2|Bacteria,1QGT9@1224|Proteobacteria,1TE8U@1236|Gammaproteobacteria,3XRDQ@561|Escherichia 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_1241606_1 396588.Tgr7_3067 8.15e-24 97.1 COG1018@1|root,COG1018@2|Bacteria,1MW37@1224|Proteobacteria,1RR95@1236|Gammaproteobacteria,1WVUK@135613|Chromatiales 135613|Chromatiales C PFAM oxidoreductase FAD NAD(P)-binding domain protein - - 1.18.1.2,1.19.1.1 ko:K00528 - - R10159 - ko00000,ko01000 - - - FAD_binding_6,NAD_binding_1 k59_1802256_1 1122137.AQXF01000001_gene3101 6.09e-76 250.0 COG1629@1|root,COG4774@1|root,COG1629@2|Bacteria,COG4774@2|Bacteria,1NMCN@1224|Proteobacteria,2TW2G@28211|Alphaproteobacteria 28211|Alphaproteobacteria P receptor - - - - - - - - - - - - Plug,TonB_dep_Rec k59_1637672_1 1122137.AQXF01000006_gene868 3.47e-172 501.0 COG1200@1|root,COG1200@2|Bacteria,1MWN2@1224|Proteobacteria,2TR86@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) recG GO:0003674,GO:0003678,GO:0003724,GO:0003824,GO:0004003,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006807,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0008186,GO:0009314,GO:0009379,GO:0009628,GO:0009987,GO:0010501,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0032991,GO:0033202,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0051276,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:0140098,GO:1901360,GO:1902494 3.6.4.12 ko:K03655 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,Helicase_C,RecG_wedge k59_1127091_1 768671.ThimaDRAFT_3681 8.06e-84 259.0 COG0626@1|root,COG0626@2|Bacteria,1MU57@1224|Proteobacteria,1RMCV@1236|Gammaproteobacteria,1WWGS@135613|Chromatiales 135613|Chromatiales E Catalyzes the formation of L-homocysteine from O- succinyl-L-homoserine (OSHS) and hydrogen sulfide metZ - - ko:K10764 ko00270,ko00920,ko01100,map00270,map00920,map01100 - R01288 RC00020,RC02848 ko00000,ko00001,ko01000 - - - Cys_Met_Meta_PP k59_1802260_1 1207055.C100_16830 1.82e-108 323.0 COG0583@1|root,COG0583@2|Bacteria,1PEF2@1224|Proteobacteria,2TU0U@28211|Alphaproteobacteria,2K4D4@204457|Sphingomonadales 204457|Sphingomonadales K Bacterial regulatory helix-turn-helix protein, lysR family - - - - - - - - - - - - HTH_1,LysR_substrate k59_1637679_1 382464.ABSI01000011_gene2554 3.66e-67 217.0 COG0304@1|root,COG0304@2|Bacteria,46SBU@74201|Verrucomicrobia,2ITS2@203494|Verrucomicrobiae 2|Bacteria I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP fabB GO:0003674,GO:0003824,GO:0004312,GO:0004315,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0072330,GO:1901576 2.3.1.41 ko:K00647 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119 RC00039,RC02728,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - iAF1260.b2323,iAPECO1_1312.APECO1_4241,iB21_1397.B21_02208,iBWG_1329.BWG_2097,iE2348C_1286.E2348C_2463,iEC042_1314.EC042_2564,iEC55989_1330.EC55989_2567,iECABU_c1320.ECABU_c26560,iECBD_1354.ECBD_1336,iECB_1328.ECB_02248,iECDH10B_1368.ECDH10B_2485,iECDH1ME8569_1439.ECDH1ME8569_2261,iECD_1391.ECD_02248,iECED1_1282.ECED1_2787,iECIAI1_1343.ECIAI1_2400,iECIAI39_1322.ECIAI39_2472,iECNA114_1301.ECNA114_2414,iECO103_1326.ECO103_2787,iECO111_1330.ECO111_3071,iECO26_1355.ECO26_3311,iECOK1_1307.ECOK1_2605,iECP_1309.ECP_2362,iECS88_1305.ECS88_2471,iECSE_1348.ECSE_2632,iECSF_1327.ECSF_2200,iECUMN_1333.ECUMN_2663,iECW_1372.ECW_m2512,iEKO11_1354.EKO11_1442,iETEC_1333.ETEC_2459,iEcDH1_1363.EcDH1_1333,iEcHS_1320.EcHS_A2474,iEcSMS35_1347.EcSMS35_2480,iEcolC_1368.EcolC_1329,iJN746.PP_4175,iJO1366.b2323,iJR904.b2323,iLF82_1304.LF82_0605,iNRG857_1313.NRG857_11765,iSBO_1134.SBO_2360,iUMN146_1321.UM146_05195,iUTI89_1310.UTI89_C2608,iWFL_1372.ECW_m2512,iY75_1357.Y75_RS12180,ic_1306.c2869 Ketoacyl-synt_C,ketoacyl-synt k59_560098_1 1121912.AUHD01000006_gene1336 1.64e-89 283.0 COG0457@1|root,COG2972@1|root,COG0457@2|Bacteria,COG2972@2|Bacteria,4NF45@976|Bacteroidetes,1HXUR@117743|Flavobacteriia 976|Bacteroidetes T Histidine kinase - - - - - - - - - - - - His_kinase,SNAP,TPR_12,TPR_16,TPR_7,TPR_8 k59_1637681_1 501479.ACNW01000105_gene522 1.01e-12 74.7 COG3710@1|root,COG3899@1|root,COG3903@1|root,COG3710@2|Bacteria,COG3899@2|Bacteria,COG3903@2|Bacteria,1MUDT@1224|Proteobacteria,2U2S9@28211|Alphaproteobacteria 28211|Alphaproteobacteria K AAA ATPase domain - - - - - - - - - - - - AAA_16,Trans_reg_C k59_560109_1 1123242.JH636434_gene4576 3.52e-57 201.0 COG1201@1|root,COG1201@2|Bacteria,2IX0G@203682|Planctomycetes 203682|Planctomycetes L DEAD DEAH box helicase - - - ko:K03724 - - - - ko00000,ko01000,ko03400 - - - DEAD,DEAD_assoc,Helicase_C k59_168175_1 1499967.BAYZ01000014_gene6390 3.47e-48 169.0 COG0438@1|root,COG0438@2|Bacteria 2|Bacteria M transferase activity, transferring glycosyl groups - - - - - - - - - - - - Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1 k59_1693133_1 1120953.AUBH01000002_gene1579 1.08e-27 112.0 COG1283@1|root,COG1283@2|Bacteria,1MUDE@1224|Proteobacteria,1S1YQ@1236|Gammaproteobacteria,46DG4@72275|Alteromonadaceae 1236|Gammaproteobacteria P Na+/Pi-cotransporter yjbB - - ko:K03324 - - - - ko00000,ko02000 2.A.58.2 - - Na_Pi_cotrans,PhoU k59_504225_1 1192759.AKIB01000074_gene633 4.38e-70 217.0 COG1192@1|root,COG1192@2|Bacteria,1R8ZH@1224|Proteobacteria,2U891@28211|Alphaproteobacteria,2K44D@204457|Sphingomonadales 204457|Sphingomonadales D VirC1 protein - - - ko:K03496 - - - - ko00000,ko03036,ko04812 - - - VirC1 k59_1012635_1 1122197.ATWI01000012_gene553 1.09e-28 110.0 2ANPA@1|root,31DNS@2|Bacteria,1RHTE@1224|Proteobacteria,1S78C@1236|Gammaproteobacteria,467E1@72275|Alteromonadaceae 1236|Gammaproteobacteria S Protein of unknown function (DUF3833) PP2730 - - - - - - - - - - - DUF3833 k59_168177_1 187272.Mlg_2763 1.18e-183 555.0 COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,1MU7B@1224|Proteobacteria,1RN2W@1236|Gammaproteobacteria,1WWAR@135613|Chromatiales 135613|Chromatiales E glutamate synthase - - 1.4.1.13,1.4.1.14 ko:K00265 ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 - R00093,R00114,R00248 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - GATase_2,GXGXG,Glu_syn_central,Glu_synthase k59_1241613_1 702113.PP1Y_AT13810 2.59e-37 138.0 COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,2TSYQ@28211|Alphaproteobacteria,2K1U5@204457|Sphingomonadales 204457|Sphingomonadales O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins ftsH - - ko:K03798 - M00742 - - ko00000,ko00002,ko01000,ko01002,ko03110 - - - AAA,FtsH_ext,Peptidase_M41 k59_560144_1 436308.Nmar_0944 1.74e-118 352.0 COG1111@1|root,arCOG00872@2157|Archaea 2157|Archaea L DEAD DEAH box helicase domain protein - - - ko:K03703,ko:K10896 ko03420,ko03460,map03420,map03460 M00413 - - ko00000,ko00001,ko00002,ko03400 - - - DEAD,ERCC4,HHH_2,HHH_5,Helicase_C,ResIII k59_1802307_1 1122137.AQXF01000003_gene2409 1.11e-72 224.0 COG2930@1|root,COG2930@2|Bacteria,1RCH3@1224|Proteobacteria 1224|Proteobacteria S (twin-arginine translocation) pathway signal - - - - - - - - - - - - Ysc84 k59_504241_1 1245471.PCA10_28390 3.75e-115 356.0 COG1960@1|root,COG1960@2|Bacteria,1MVJC@1224|Proteobacteria,1RPZ9@1236|Gammaproteobacteria,1YHT6@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria I Acyl-CoA dehydrogenase, C-terminal domain - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_1298686_2 1201288.M900_2516 5.75e-12 62.8 COG1495@1|root,COG1495@2|Bacteria,1N2C1@1224|Proteobacteria 1224|Proteobacteria O Belongs to the DsbB family bdbC - - ko:K03611 - - - - ko00000,ko03110 5.A.2.1 - - DsbB k59_1468454_1 1122137.AQXF01000005_gene1106 3.32e-116 345.0 COG1322@1|root,COG1322@2|Bacteria,1MWHV@1224|Proteobacteria,2TTX6@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Protein conserved in bacteria rmuC - - ko:K09760 - - - - ko00000 - - - RmuC k59_1298695_1 1209072.ALBT01000033_gene1678 7.99e-29 118.0 COG1629@1|root,COG4771@2|Bacteria,1MXSN@1224|Proteobacteria,1RZC0@1236|Gammaproteobacteria,1FH3Q@10|Cellvibrio 1236|Gammaproteobacteria P TonB dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_562775_1 1415780.JPOG01000001_gene2635 2.86e-129 388.0 COG4630@1|root,COG4630@2|Bacteria,1MWI1@1224|Proteobacteria,1RQ5C@1236|Gammaproteobacteria,1X5P1@135614|Xanthomonadales 135614|Xanthomonadales F CO dehydrogenase flavoprotein C-terminal domain - - - - - - - - - - - - CO_deh_flav_C,FAD_binding_5,Fer2,Fer2_2 k59_1804825_2 865937.Gilli_1235 0.000431 47.8 COG3677@1|root,COG3677@2|Bacteria,4P01J@976|Bacteroidetes,1I83K@117743|Flavobacteriia 976|Bacteroidetes L Transposase - - - - - - - - - - - - DDE_Tnp_IS1595,Zn_Tnp_IS1595 k59_677598_1 1122137.AQXF01000004_gene1681 5.98e-88 270.0 COG0628@1|root,COG0628@2|Bacteria,1MW0B@1224|Proteobacteria,2TRD3@28211|Alphaproteobacteria 28211|Alphaproteobacteria S permease - - - ko:K03548 - - - - ko00000,ko02000 2.A.86.1 - - AI-2E_transport k59_677598_2 1122137.AQXF01000004_gene1682 3.12e-39 136.0 COG1028@1|root,COG1028@2|Bacteria,1R413@1224|Proteobacteria,2TW0W@28211|Alphaproteobacteria 28211|Alphaproteobacteria IQ short-chain dehydrogenase - - - - - - - - - - - - adh_short_C2 k59_514682_1 498211.CJA_1614 1.71e-37 142.0 COG0608@1|root,COG0608@2|Bacteria,1MU1M@1224|Proteobacteria,1RMF4@1236|Gammaproteobacteria,1FGUD@10|Cellvibrio 1236|Gammaproteobacteria L DHH family recJ GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0006139,GO:0006259,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008297,GO:0008409,GO:0009314,GO:0009628,GO:0009987,GO:0010165,GO:0010212,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0033554,GO:0034641,GO:0035312,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0045145,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360 - ko:K07462 ko03410,ko03430,ko03440,map03410,map03430,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DHH,DHHA1 k59_63763_1 1366050.N234_36180 2.1e-118 351.0 COG3335@1|root,COG3335@2|Bacteria,1MW7X@1224|Proteobacteria,2VMDX@28216|Betaproteobacteria,1K2WH@119060|Burkholderiaceae 28216|Betaproteobacteria L Elements of external origin - - - ko:K07494 - - - - ko00000 - - - DDE_3,HTH_23,HTH_32 k59_798121_1 1047171.Mycgr3P40002 1.17e-22 102.0 COG0318@1|root,KOG1176@2759|Eukaryota,39W57@33154|Opisthokonta,3NYCE@4751|Fungi,3QPSS@4890|Ascomycota,204ED@147541|Dothideomycetes,3MH2Q@451867|Dothideomycetidae 4751|Fungi I AMP-binding enzyme C-terminal domain - - - - - - - - - - - - AMP-binding,AMP-binding_C k59_7052_1 316407.85674747 2.85e-46 164.0 COG3188@1|root,COG3188@2|Bacteria,1P744@1224|Proteobacteria,1RN8Z@1236|Gammaproteobacteria,3XMSW@561|Escherichia 1236|Gammaproteobacteria NU outer membrane usher protein ybgQ GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0006810,GO:0008150,GO:0009279,GO:0009297,GO:0009987,GO:0015267,GO:0015288,GO:0015473,GO:0016020,GO:0016043,GO:0019867,GO:0022607,GO:0022803,GO:0022829,GO:0022857,GO:0030030,GO:0030031,GO:0030312,GO:0030313,GO:0031975,GO:0043711,GO:0044085,GO:0044462,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071840,GO:0071944 - - - - - - - - - - PapC_C,PapC_N,Usher k59_7052_2 316407.4062313 3.05e-64 201.0 COG3121@1|root,COG3121@2|Bacteria,1MY06@1224|Proteobacteria,1RN7Y@1236|Gammaproteobacteria,3XPFT@561|Escherichia 1236|Gammaproteobacteria M chaperone ybgP GO:0006457,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0033554,GO:0050896,GO:0051716 - - - - - - - - - - PapD_C,PapD_N k59_1362655_1 314285.KT71_01240 2.07e-92 299.0 COG1629@1|root,COG4771@2|Bacteria,1MUNK@1224|Proteobacteria,1RN9S@1236|Gammaproteobacteria 1236|Gammaproteobacteria P COG1629 Outer membrane receptor proteins, mostly Fe transport - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_1588240_1 314265.R2601_25431 3e-14 77.8 COG2931@1|root,COG5295@1|root,COG2931@2|Bacteria,COG5295@2|Bacteria,1MU7T@1224|Proteobacteria,2TRVY@28211|Alphaproteobacteria 28211|Alphaproteobacteria Q COG2931 RTX toxins and related Ca2 -binding proteins - - - - - - - - - - - - DUF4114,Hint_2 k59_1079919_1 1122130.AUHN01000009_gene572 6.4e-99 303.0 COG1894@1|root,COG1894@2|Bacteria,2GMMC@201174|Actinobacteria 201174|Actinobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain nuoF - 1.6.5.3 ko:K00335 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_51K,NADH_4Fe-4S,SLBB k59_346216_2 1121374.KB891575_gene1104 6.29e-20 89.0 COG1834@1|root,COG1834@2|Bacteria,1MZ9U@1224|Proteobacteria,1RN0M@1236|Gammaproteobacteria 1236|Gammaproteobacteria E Amidinotransferase - - 3.5.3.18 ko:K01482 - - - - ko00000,ko01000,ko04147 - - - Amidinotransf k59_1362665_1 1197477.IA57_12715 3.4e-72 227.0 COG3064@1|root,COG3064@2|Bacteria,4NESI@976|Bacteroidetes,1HXS4@117743|Flavobacteriia 976|Bacteroidetes M membrane - - - - - - - - - - - - PorP_SprF k59_1079925_1 1122137.AQXF01000006_gene879 2.65e-132 384.0 COG5330@1|root,COG5330@2|Bacteria,1R3VY@1224|Proteobacteria,2TUQ8@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Uncharacterised protein conserved in bacteria (DUF2336) - - - - - - - - - - - - DUF2336 k59_1306474_1 566466.NOR53_571 6.46e-80 250.0 COG0151@1|root,COG0151@2|Bacteria,1MUAH@1224|Proteobacteria,1RNS4@1236|Gammaproteobacteria,1J85E@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria F Phosphoribosylglycinamide synthetase, C domain purD GO:0000166,GO:0003674,GO:0003824,GO:0004637,GO:0005488,GO:0005524,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016874,GO:0016879,GO:0016887,GO:0017076,GO:0017111,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0033554,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0050896,GO:0051716,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.3.2.6,6.3.4.13 ko:K01945,ko:K13713 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04144,R04591 RC00064,RC00090,RC00162,RC00166 ko00000,ko00001,ko00002,ko01000 - - iECNA114_1301.ECNA114_3417,iECSF_1327.ECSF_3859,iJN746.PP_4823,iPC815.YPO3729 GARS_A,GARS_C,GARS_N k59_458678_1 1265505.ATUG01000001_gene4242 1.56e-20 94.7 COG0697@1|root,COG0697@2|Bacteria,1R03B@1224|Proteobacteria,42S5I@68525|delta/epsilon subdivisions,2WNXS@28221|Deltaproteobacteria,2MNCD@213118|Desulfobacterales 28221|Deltaproteobacteria EG EamA-like transporter family - - - - - - - - - - - - EamA k59_402105_1 1229485.AMYV01000121_gene2623 4.15e-27 105.0 COG1028@1|root,COG1028@2|Bacteria,1MUD2@1224|Proteobacteria,1RN5N@1236|Gammaproteobacteria 1236|Gammaproteobacteria IQ involved in the biosynthesis of siderophores, enterobactin, bacillibactin or vibriobactin entA - 1.3.1.28 ko:K00216 ko01053,ko01110,ko01130,map01053,map01110,map01130 - R01505 RC00534 ko00000,ko00001,ko01000 - - - adh_short_C2 k59_402105_2 1211112.ALJC01000102_gene2377 8.21e-09 59.7 COG2977@1|root,COG2977@2|Bacteria,1MZK2@1224|Proteobacteria,1S968@1236|Gammaproteobacteria 1236|Gammaproteobacteria Q Belongs to the P-Pant transferase superfamily pcpS - 6.3.2.14 ko:K02362 ko01053,ko01110,ko01130,map01053,map01110,map01130 - R07644 RC00162,RC03046 ko00000,ko00001,ko01000 - - - ACPS k59_571428_2 216595.PFLU_2603 5.48e-38 139.0 COG2207@1|root,COG2207@2|Bacteria,1R453@1224|Proteobacteria 1224|Proteobacteria K Transcriptional regulator - - - - - - - - - - - - AraC_binding,HTH_18 k59_1136514_1 436308.Nmar_1721 2.02e-69 223.0 COG0452@1|root,arCOG01704@2157|Archaea,41SYG@651137|Thaumarchaeota 651137|Thaumarchaeota H Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine - - 4.1.1.36,6.3.2.5 ko:K13038 ko00770,ko01100,map00770,map01100 M00120 R03269,R04231 RC00064,RC00090,RC00822 ko00000,ko00001,ko00002,ko01000 - - - DFP,Flavoprotein k59_1757996_1 261292.Nit79A3_2730 8.71e-57 193.0 COG3039@1|root,COG3039@2|Bacteria,1Q9GN@1224|Proteobacteria,2WCRD@28216|Betaproteobacteria,373TB@32003|Nitrosomonadales 28216|Betaproteobacteria L Transposase DDE domain - - - - - - - - - - - - DDE_Tnp_1_2,DUF772 k59_684492_1 1148.1652377 2.63e-28 109.0 COG2203@1|root,COG2203@2|Bacteria,1GIH9@1117|Cyanobacteria,1H6HY@1142|Synechocystis 1117|Cyanobacteria T GAF domain - - - - - - - - - - - - GAF k59_1079945_1 465541.ATCJ01000005_gene2026 1.63e-16 81.3 COG1741@1|root,COG1741@2|Bacteria,2IBMG@201174|Actinobacteria 201174|Actinobacteria S Pirin C-terminal cupin domain - - - ko:K06911 - - - - ko00000 - - - Pirin,Pirin_C k59_120182_1 1144319.PMI16_04046 8.58e-07 52.8 COG3386@1|root,COG3386@2|Bacteria,1MWTR@1224|Proteobacteria,2VMAD@28216|Betaproteobacteria,475FU@75682|Oxalobacteraceae 28216|Betaproteobacteria G SMP-30/Gluconolaconase/LRE-like region - - 3.1.1.15 ko:K13874,ko:K14274 ko00040,ko00053,ko01100,map00040,map00053,map01100 - R02427,R02526 RC00537,RC00713 ko00000,ko00001,ko01000 - - - SGL k59_120182_2 1123269.NX02_07110 1.29e-25 104.0 COG0673@1|root,COG0673@2|Bacteria,1MW0Q@1224|Proteobacteria,2TQR0@28211|Alphaproteobacteria,2K0NU@204457|Sphingomonadales 204457|Sphingomonadales S Galactose 1-dehydrogenase - - 1.1.1.48 ko:K00035 ko00052,ko01100,map00052,map01100 - R01094,R01097 RC00161 ko00000,ko00001,ko01000 - - - GFO_IDH_MocA k59_63820_1 717785.HYPMC_2840 3.05e-49 174.0 COG0579@1|root,COG0579@2|Bacteria,1N0QB@1224|Proteobacteria,2TU6K@28211|Alphaproteobacteria,3N7MZ@45401|Hyphomicrobiaceae 28211|Alphaproteobacteria S FAD dependent oxidoreductase MA20_03725 - - - - - - - - - - - DAO k59_1362709_2 1229909.NSED_01420 2.05e-103 305.0 COG2520@1|root,arCOG00033@2157|Archaea,41S7P@651137|Thaumarchaeota 651137|Thaumarchaeota J Met-10+ like-protein - - 2.1.1.228 ko:K15429 - - R00597 RC00003,RC00334 ko00000,ko01000,ko03016 - - - Met_10 k59_1701400_1 1229909.NSED_09290 8.5e-149 423.0 COG0524@1|root,arCOG00014@2157|Archaea,41SX4@651137|Thaumarchaeota 651137|Thaumarchaeota G pfkB family carbohydrate kinase - - - - - - - - - - - - PfkB k59_1701400_2 1229909.NSED_09285 6.32e-46 154.0 arCOG08767@1|root,arCOG08767@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_1362712_1 1121374.KB891575_gene1211 9.16e-44 152.0 COG0368@1|root,COG0368@2|Bacteria,1RHCC@1224|Proteobacteria,1S4TE@1236|Gammaproteobacteria 1236|Gammaproteobacteria H Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate cobS GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008818,GO:0009058,GO:0009110,GO:0009235,GO:0009236,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016780,GO:0017144,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042364,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.8.26 ko:K02233 ko00860,ko01100,map00860,map01100 M00122 R05223,R11174 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - iECH74115_1262.ECH74115_2837,iECO103_1326.ECO103_2453,iECSP_1301.ECSP_2657,iECs_1301.ECs2787,iG2583_1286.G2583_2502,iUTI89_1310.UTI89_C2230,iZ_1308.Z3152,ic_1306.c2478 CobS k59_684503_1 1502770.JQMG01000001_gene2352 1.19e-114 331.0 COG0717@1|root,COG0717@2|Bacteria,1MV2J@1224|Proteobacteria,2VIJ0@28216|Betaproteobacteria,2KMDH@206350|Nitrosomonadales 206350|Nitrosomonadales F Belongs to the dCTP deaminase family dcd - 3.5.4.13 ko:K01494 ko00240,ko01100,map00240,map01100 M00053 R00568,R02325 RC00074 ko00000,ko00001,ko00002,ko01000 - - - dUTPase k59_1418935_1 357804.Ping_0504 6.26e-73 233.0 COG3633@1|root,COG3633@2|Bacteria,1MXE1@1224|Proteobacteria,1RP9B@1236|Gammaproteobacteria,2QHP5@267894|Psychromonadaceae 1236|Gammaproteobacteria E Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) sstT GO:0003333,GO:0003674,GO:0005215,GO:0005283,GO:0005295,GO:0005310,GO:0005342,GO:0005343,GO:0005416,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006814,GO:0006820,GO:0006835,GO:0006865,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0015075,GO:0015077,GO:0015081,GO:0015171,GO:0015175,GO:0015291,GO:0015293,GO:0015294,GO:0015318,GO:0015370,GO:0015672,GO:0015711,GO:0015804,GO:0015849,GO:0016020,GO:0016021,GO:0017153,GO:0022804,GO:0022857,GO:0022890,GO:0030001,GO:0031224,GO:0032329,GO:0034220,GO:0035725,GO:0044425,GO:0044464,GO:0046873,GO:0046942,GO:0046943,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0098655,GO:0098656,GO:0098660,GO:0098662,GO:1903825,GO:1905039 - ko:K07862 - - - - ko00000,ko02000 2.A.23.4 - iAF1260.b3089,iBWG_1329.BWG_2799,iECDH10B_1368.ECDH10B_3265,iECDH1ME8569_1439.ECDH1ME8569_2984,iECH74115_1262.ECH74115_4404,iECIAI1_1343.ECIAI1_3235,iECO103_1326.ECO103_3834,iECO111_1330.ECO111_3911,iECO26_1355.ECO26_4192,iECP_1309.ECP_3180,iECSE_1348.ECSE_3370,iECSP_1301.ECSP_4063,iECUMN_1333.ECUMN_3573,iECW_1372.ECW_m3356,iECs_1301.ECs3971,iEKO11_1354.EKO11_0630,iETEC_1333.ETEC_3359,iEcDH1_1363.EcDH1_0612,iEcE24377_1341.EcE24377A_3557,iG2583_1286.G2583_3813,iJO1366.b3089,iJR904.b3089,iSFV_1184.SFV_3130,iSSON_1240.SSON_3242,iUMNK88_1353.UMNK88_3845,iWFL_1372.ECW_m3356,iY75_1357.Y75_RS16050,iYL1228.KPN_03517,iZ_1308.Z4442 SDF k59_571454_1 292459.STH1426 2.79e-119 365.0 COG1132@1|root,COG1132@2|Bacteria,1TRCZ@1239|Firmicutes,24C4R@186801|Clostridia 186801|Clostridia V ABC transporter transmembrane region - - - ko:K06147 - - - - ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran k59_176167_1 1122962.AULH01000016_gene147 1.05e-08 59.3 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2TQPG@28211|Alphaproteobacteria,36XRE@31993|Methylocystaceae 28211|Alphaproteobacteria T Sigma-54 interaction domain flbD - - ko:K10943 ko02020,ko05111,map02020,map05111 M00515 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_176167_2 667014.Thein_1809 3.16e-12 67.0 COG1815@1|root,COG1815@2|Bacteria,2GHT6@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria N Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body - - - ko:K02387 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - Flg_bb_rod k59_176167_3 237368.SCABRO_00037 1.02e-05 46.6 COG1558@1|root,COG1558@2|Bacteria,2J09G@203682|Planctomycetes 203682|Planctomycetes N Belongs to the flagella basal body rod proteins family flgC - - ko:K02388 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - Flg_bb_rod,Flg_bbr_C k59_628096_1 1089545.KB913037_gene6345 1.04e-18 89.0 COG1529@1|root,COG1529@2|Bacteria,2GIVI@201174|Actinobacteria,4DZTZ@85010|Pseudonocardiales 201174|Actinobacteria C Aldehyde oxidase and xanthine dehydrogenase, a b hammerhead - - 1.2.5.3 ko:K03520 - - R11168 RC02800 ko00000,ko01000 - - - Ald_Xan_dh_C,Ald_Xan_dh_C2 k59_798180_1 1121405.dsmv_3800 5.81e-41 149.0 COG0517@1|root,COG0517@2|Bacteria,1MXI6@1224|Proteobacteria,42SSD@68525|delta/epsilon subdivisions,2WPWR@28221|Deltaproteobacteria,2MK6M@213118|Desulfobacterales 28221|Deltaproteobacteria S Putative transposase - - - - - - - - - - - - Y2_Tnp,Zn_Tnp_IS91 k59_1758028_1 1215092.PA6_029_00030 3.79e-94 290.0 COG0554@1|root,COG0554@2|Bacteria,1MUP7@1224|Proteobacteria,1RMAF@1236|Gammaproteobacteria,1YDPI@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria F Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate glpK GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615 2.7.1.30 ko:K00864 ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626 - R00847 RC00002,RC00017 ko00000,ko00001,ko01000,ko04147 - - - FGGY_C,FGGY_N k59_966990_1 1122921.KB898186_gene5095 2.58e-60 207.0 COG3459@1|root,COG3459@2|Bacteria,1V17H@1239|Firmicutes,4HFJ4@91061|Bacilli,275SG@186822|Paenibacillaceae 91061|Bacilli G Glycosyltransferase family 36 - - 2.4.1.321 ko:K18786 - - R10832 RC00397 ko00000,ko01000 - - - Glyco_hydro_36,Glyco_transf_36 k59_1758029_1 1392486.JIAF01000004_gene2403 5.15e-09 63.9 COG4772@1|root,COG4772@2|Bacteria,4NF0U@976|Bacteroidetes,2FM7N@200643|Bacteroidia 976|Bacteroidetes P TonB-dependent receptor - - - - - - - - - - - - Plug,TonB_dep_Rec k59_402155_1 395495.Lcho_2747 3.03e-44 155.0 COG1526@1|root,COG1526@2|Bacteria,1NRU0@1224|Proteobacteria,2VQ5Z@28216|Betaproteobacteria,1KKS3@119065|unclassified Burkholderiales 28216|Betaproteobacteria C Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH fdhD - - ko:K02379 - - - - ko00000 - - - FdhD-NarQ k59_63858_1 1123322.KB904702_gene139 3.66e-58 201.0 COG1926@1|root,COG2312@1|root,COG1926@2|Bacteria,COG2312@2|Bacteria,2GJUU@201174|Actinobacteria 201174|Actinobacteria Q phosphoribosyltransferase - GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944 - ko:K07100 - - - - ko00000 - - - Erythro_esteras,Pribosyltran k59_1136571_1 322710.Avin_45580 3.64e-18 81.3 COG3647@1|root,COG3647@2|Bacteria,1N7NB@1224|Proteobacteria,1SAV7@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Predicted membrane protein (DUF2238) - - - ko:K08984 - - - - ko00000 - - - DUF2238 k59_1136571_2 202954.BBNK01000010_gene1366 1.12e-48 157.0 COG0346@1|root,COG0346@2|Bacteria,1RCYX@1224|Proteobacteria,1S1Z9@1236|Gammaproteobacteria,3NN4K@468|Moraxellaceae 1236|Gammaproteobacteria E Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione gloA GO:0003674,GO:0003824,GO:0004462,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006082,GO:0006089,GO:0006518,GO:0006575,GO:0006749,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009438,GO:0009987,GO:0016151,GO:0016829,GO:0016846,GO:0019243,GO:0019752,GO:0032787,GO:0034641,GO:0042180,GO:0042182,GO:0043167,GO:0043169,GO:0043436,GO:0043603,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046185,GO:0046872,GO:0046914,GO:0051186,GO:0051596,GO:0061727,GO:0071704,GO:1901564,GO:1901575,GO:1901615 4.4.1.5 ko:K01759 ko00620,map00620 - R02530 RC00004,RC00740 ko00000,ko00001,ko01000 - - iAPECO1_1312.APECO1_733,iECABU_c1320.ECABU_c19040,iECED1_1282.ECED1_1851,iECNA114_1301.ECNA114_1699,iECOK1_1307.ECOK1_1770,iECP_1309.ECP_1597,iECS88_1305.ECS88_1700,iECSF_1327.ECSF_1514,iLF82_1304.LF82_0861,iNRG857_1313.NRG857_08275,iUMN146_1321.UM146_08895,iUTI89_1310.UTI89_C1842,ic_1306.c2044 Glyoxalase k59_1532478_1 158500.BV97_00339 2.31e-18 82.0 COG2267@1|root,COG2267@2|Bacteria,1QUNU@1224|Proteobacteria,2TW29@28211|Alphaproteobacteria,2K09G@204457|Sphingomonadales 204457|Sphingomonadales I hydrolases or acyltransferases (alpha beta hydrolase superfamily) - - - - - - - - - - - - Abhydrolase_1,Abhydrolase_6 k59_1532478_2 1122970.AUHC01000004_gene2200 3.33e-49 160.0 COG0599@1|root,COG0599@2|Bacteria,1MZ80@1224|Proteobacteria,2UDE8@28211|Alphaproteobacteria,2K5WZ@204457|Sphingomonadales 204457|Sphingomonadales S Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - - - - - - - - - - CMD k59_741378_1 1380600.AUYN01000001_gene2239 1.51e-82 256.0 COG0141@1|root,COG0141@2|Bacteria,4NFPZ@976|Bacteroidetes,1HZ69@117743|Flavobacteriia 976|Bacteroidetes E Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine hisD GO:0000105,GO:0003674,GO:0003824,GO:0004399,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0052803,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.23 ko:K00013 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R01158,R01163,R03012 RC00099,RC00242,RC00463 ko00000,ko00001,ko00002,ko01000 - - - Histidinol_dh k59_967003_1 671143.DAMO_0314 8.18e-11 67.8 COG0795@1|root,COG0795@2|Bacteria,2NPHN@2323|unclassified Bacteria 2|Bacteria S Permease YjgP YjgQ lptG - - ko:K11720 ko02010,map02010 M00320 - - ko00000,ko00001,ko00002,ko02000 1.B.42.1 - - YjgP_YjgQ k59_1024376_1 595537.Varpa_3007 8.09e-199 571.0 COG1523@1|root,COG1523@2|Bacteria,1MU19@1224|Proteobacteria,2VH8E@28216|Betaproteobacteria,4AC1I@80864|Comamonadaceae 28216|Betaproteobacteria G PFAM glycoside hydrolase, family 13 domain protein - - 3.2.1.196,3.2.1.68 ko:K01214,ko:K02438 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R02111,R09995,R11261 - ko00000,ko00001,ko00002,ko01000 - CBM48,GH13 - Alpha-amylase,CBM_48 k59_7135_1 702113.PP1Y_Mpl616 3.94e-06 49.7 COG0477@1|root,COG2814@2|Bacteria,1MW19@1224|Proteobacteria,2TRJ1@28211|Alphaproteobacteria,2K0JH@204457|Sphingomonadales 204457|Sphingomonadales EGP Major facilitator superfamily - - - ko:K07552 - - - - ko00000,ko02000 2.A.1.2 - - MFS_1 k59_7135_2 1068980.ARVW01000001_gene3248 1.56e-52 186.0 COG2271@1|root,COG2271@2|Bacteria,2GIS1@201174|Actinobacteria,4E0DR@85010|Pseudonocardiales 201174|Actinobacteria G Major Facilitator Superfamily - - - ko:K13021 - - - - ko00000,ko02000 2.A.1.14.3 - - MFS_1 k59_628112_1 983544.Lacal_2698 9.55e-66 216.0 COG0739@1|root,COG0739@2|Bacteria,4NED7@976|Bacteroidetes,1HXKD@117743|Flavobacteriia 976|Bacteroidetes M peptidase M23 - - - - - - - - - - - - Peptidase_M23 k59_628112_2 983544.Lacal_2697 1.17e-29 108.0 2E695@1|root,330X7@2|Bacteria,4NVE0@976|Bacteroidetes,1I53C@117743|Flavobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_628112_3 1249975.JQLP01000008_gene419 3.57e-19 79.7 COG3027@1|root,COG3027@2|Bacteria,4NSA5@976|Bacteroidetes,1I41M@117743|Flavobacteriia,2P6XS@244698|Gillisia 976|Bacteroidetes D Cell division protein ZapA zapA - - ko:K09888 - - - - ko00000,ko03036 - - - ZapA k59_458768_1 1229909.NSED_02095 2.68e-45 149.0 COG3439@1|root,arCOG02761@2157|Archaea 2157|Archaea S Domain of unknown function DUF302 - - - - - - - - - - - - DUF302 k59_458768_2 1229909.NSED_03070 7.02e-106 316.0 COG1253@1|root,arCOG00626@2157|Archaea 2157|Archaea S COG1253 Hemolysins and related proteins containing CBS domains cbs9 - - ko:K03699 - - - - ko00000,ko02042 - - - CBS,CorC_HlyC,DUF21 k59_346334_1 502025.Hoch_6366 1.93e-48 168.0 COG0330@1|root,COG0330@2|Bacteria,1PEW9@1224|Proteobacteria,430NQ@68525|delta/epsilon subdivisions,2WVUU@28221|Deltaproteobacteria,2YVM2@29|Myxococcales 28221|Deltaproteobacteria O SPFH domain / Band 7 family - - - - - - - - - - - - Band_7 k59_346334_2 1713.JOFV01000006_gene2852 9.29e-36 132.0 COG0061@1|root,COG0061@2|Bacteria,2GM34@201174|Actinobacteria 201174|Actinobacteria G Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP - - - - - - - - - - - - NAD_kinase k59_1701450_1 323848.Nmul_A1846 1.7e-58 192.0 COG0247@1|root,COG0247@2|Bacteria,1MWTK@1224|Proteobacteria,2VJ6T@28216|Betaproteobacteria,372WA@32003|Nitrosomonadales 28216|Betaproteobacteria C Cysteine-rich domain - - - - - - - - - - - - CCG,DUF3501 k59_1701450_2 1198232.CYCME_1032 6.62e-14 69.7 COG0247@1|root,COG0247@2|Bacteria,1RF02@1224|Proteobacteria,1S302@1236|Gammaproteobacteria,462CF@72273|Thiotrichales 72273|Thiotrichales C Protein of unknown function (DUF3501) - - - - - - - - - - - - DUF3501 k59_1475994_1 38654.XP_006033797.1 9.23e-83 269.0 COG1233@1|root,KOG4254@2759|Eukaryota,38CXC@33154|Opisthokonta,3BDJK@33208|Metazoa,3CVDZ@33213|Bilateria,4861H@7711|Chordata,494P3@7742|Vertebrata 33208|Metazoa H oxidoreductase activity PYROXD2 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0008150,GO:0008152,GO:0016491,GO:0044464,GO:0055114 - - - - - - - - - - Amino_oxidase,NAD_binding_8 k59_967021_2 491205.JARQ01000010_gene3661 1.4e-17 83.6 COG2365@1|root,COG2365@2|Bacteria,4PFTY@976|Bacteroidetes,1IFUJ@117743|Flavobacteriia,3ZNT7@59732|Chryseobacterium 976|Bacteroidetes T Dual specificity phosphatase, catalytic domain - - - - - - - - - - - - Y_phosphatase2 k59_967021_3 69042.WH5701_02554 2.96e-12 67.8 COG0568@1|root,COG0568@2|Bacteria,1GCBK@1117|Cyanobacteria,1GZ5W@1129|Synechococcus 1117|Cyanobacteria K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released - - - ko:K03086 - - - - ko00000,ko03021 - - - Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4 k59_1418987_1 1122918.KB907283_gene1137 1.32e-39 148.0 COG0587@1|root,COG0587@2|Bacteria,1TPYG@1239|Firmicutes,4H9T3@91061|Bacilli,26QTS@186822|Paenibacillaceae 91061|Bacilli L DNA polymerase dnaE - 2.7.7.7 ko:K02337 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon k59_1701465_1 504487.JCM19302_3038 4.99e-19 84.3 28NNN@1|root,2ZBNU@2|Bacteria,4NMJD@976|Bacteroidetes,1I1SJ@117743|Flavobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_232510_1 582899.Hden_1429 6.71e-66 214.0 COG0665@1|root,COG0665@2|Bacteria,1MVGP@1224|Proteobacteria,2TRX9@28211|Alphaproteobacteria 28211|Alphaproteobacteria E oxidoreductase - - - ko:K09471 ko00330,ko01100,map00330,map01100 M00136 R07415 RC00062 ko00000,ko00001,ko00002,ko01000 - - - DAO k59_742552_1 519989.ECTPHS_05400 2.85e-76 249.0 COG2225@1|root,COG2225@2|Bacteria,1MVEV@1224|Proteobacteria,1RPVI@1236|Gammaproteobacteria,1WXV7@135613|Chromatiales 135613|Chromatiales C Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA glcB - 2.3.3.9 ko:K01638 ko00620,ko00630,ko01100,ko01110,ko01120,ko01200,map00620,map00630,map01100,map01110,map01120,map01200 M00012 R00472 RC00004,RC00308,RC02747 ko00000,ko00001,ko00002,ko01000 - - - Malate_synthase k59_1702526_1 436308.Nmar_0275 1.38e-62 194.0 COG1225@1|root,arCOG00310@2157|Archaea,41SKG@651137|Thaumarchaeota 651137|Thaumarchaeota O Redoxin - - 1.11.1.15 ko:K03564 - - - - ko00000,ko01000 - - - AhpC-TSA k59_1702526_2 1229909.NSED_01270 1.42e-16 76.6 COG5016@1|root,arCOG02095@2157|Archaea,41SKA@651137|Thaumarchaeota 651137|Thaumarchaeota C Biotin-requiring enzyme - - - ko:K18605 ko00720,ko01120,map00720,map01120 - R00742,R01859 RC00040,RC00097,RC00367,RC00609 ko00000,ko00001 - - - Biotin_lipoyl k59_742567_1 1255043.TVNIR_2215 2.17e-21 94.0 COG0072@1|root,COG0073@1|root,COG0072@2|Bacteria,COG0073@2|Bacteria,1MWKS@1224|Proteobacteria,1RMIH@1236|Gammaproteobacteria,1WW51@135613|Chromatiales 135613|Chromatiales J Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily pheT - 6.1.1.20 ko:K01890 ko00970,map00970 M00359,M00360 R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - B3_4,B5,FDX-ACB,tRNA_bind k59_742567_2 349124.Hhal_0431 2.9e-60 195.0 COG0016@1|root,COG0016@2|Bacteria,1MVD7@1224|Proteobacteria,1RN22@1236|Gammaproteobacteria,1WXAD@135613|Chromatiales 135613|Chromatiales J Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily pheS - 6.1.1.20 ko:K01889 ko00970,map00970 M00359,M00360 R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Phe_tRNA-synt_N,tRNA-synt_2d k59_290970_1 1122214.AQWH01000003_gene4083 1.25e-35 132.0 COG1363@1|root,COG1363@2|Bacteria,1MXEU@1224|Proteobacteria,2TSPX@28211|Alphaproteobacteria,2PJ1H@255475|Aurantimonadaceae 28211|Alphaproteobacteria G M42 glutamyl aminopeptidase - - - - - - - - - - - - Peptidase_M42 k59_290970_2 1177179.A11A3_07153 7.64e-41 146.0 COG4221@1|root,COG4221@2|Bacteria,1PWXN@1224|Proteobacteria,1S226@1236|Gammaproteobacteria,1XP3M@135619|Oceanospirillales 135619|Oceanospirillales S Domain of unknown function (DUF4336) - - - - - - - - - - - - DUF4336 k59_177346_1 392499.Swit_4454 2.57e-187 521.0 COG3293@1|root,COG3293@2|Bacteria,1PVIT@1224|Proteobacteria,2TURP@28211|Alphaproteobacteria,2K1TH@204457|Sphingomonadales 204457|Sphingomonadales L Transposase - - - - - - - - - - - - DDE_Tnp_1,DUF4096 k59_968186_1 1996.JOFO01000005_gene242 2.89e-43 152.0 COG0346@1|root,COG0346@2|Bacteria,2GM8H@201174|Actinobacteria,4EIS4@85012|Streptosporangiales 201174|Actinobacteria E Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily hsaC GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0006066,GO:0006629,GO:0006706,GO:0006707,GO:0008150,GO:0008152,GO:0008202,GO:0008203,GO:0009056,GO:0009405,GO:0010033,GO:0014070,GO:0016042,GO:0016125,GO:0016127,GO:0016491,GO:0016701,GO:0016702,GO:0033993,GO:0036314,GO:0042221,GO:0043167,GO:0043169,GO:0044238,GO:0044281,GO:0044282,GO:0044419,GO:0046164,GO:0046872,GO:0046914,GO:0047071,GO:0050896,GO:0051213,GO:0051704,GO:0055114,GO:0070723,GO:0071704,GO:0097305,GO:1901360,GO:1901361,GO:1901575,GO:1901615,GO:1901616,GO:1901700,GO:1902652 1.13.11.25 ko:K16049 ko00984,ko01100,ko01120,ko01220,map00984,map01100,map01120,map01220 - R04597 RC01610 ko00000,ko00001,ko01000 - - - Glyoxalase k59_968186_2 1121948.AUAC01000003_gene2770 2.35e-140 404.0 COG1788@1|root,COG1788@2|Bacteria,1NGS5@1224|Proteobacteria,2TVMU@28211|Alphaproteobacteria 28211|Alphaproteobacteria I Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit - - 2.8.3.12 ko:K01039 ko00643,ko00650,ko01120,map00643,map00650,map01120 - R04000,R05509 RC00012,RC00131,RC00137 ko00000,ko00001,ko01000 - - - CoA_trans k59_459892_1 1229909.NSED_07860 7.12e-73 235.0 arCOG06613@1|root,arCOG06613@2157|Archaea,41T0Z@651137|Thaumarchaeota 651137|Thaumarchaeota V AIPR protein - - - - - - - - - - - - AIPR k59_459892_2 1229909.NSED_07855 0.000354 43.1 COG3794@1|root,arCOG02926@2157|Archaea,41TAN@651137|Thaumarchaeota 651137|Thaumarchaeota C Copper binding proteins, plastocyanin/azurin family - - - - - - - - - - - - Copper-bind k59_347469_1 1249627.D779_0933 2.2e-66 217.0 COG0373@1|root,COG0373@2|Bacteria,1MU41@1224|Proteobacteria,1RNQ8@1236|Gammaproteobacteria,1WX0A@135613|Chromatiales 135613|Chromatiales H Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) hemA - 1.2.1.70 ko:K02492 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R04109 RC00055,RC00149 ko00000,ko00001,ko00002,ko01000 - - - GlutR_N,GlutR_dimer,Shikimate_DH k59_516046_1 861299.J421_4201 2.21e-21 87.0 2CA00@1|root,344QM@2|Bacteria,1ZU1Z@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - k59_1307589_1 1004149.AFOE01000003_gene2215 2.4e-124 367.0 COG0055@1|root,COG0055@2|Bacteria,4NF1Q@976|Bacteroidetes,1HWM2@117743|Flavobacteriia 976|Bacteroidetes C Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits atpD - 3.6.3.14 ko:K02112 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - - ATP-synt_ab,ATP-synt_ab_N k59_685657_1 234267.Acid_4326 1.59e-18 90.5 COG1075@1|root,COG1075@2|Bacteria,3Y77R@57723|Acidobacteria 57723|Acidobacteria S acetyltransferases and hydrolases with the alpha beta hydrolase fold - - - - - - - - - - - - - k59_65112_1 411464.DESPIG_02107 2.88e-13 70.1 COG0190@1|root,COG0190@2|Bacteria,1MWU4@1224|Proteobacteria,42MW0@68525|delta/epsilon subdivisions,2WJ90@28221|Deltaproteobacteria,2M9FA@213115|Desulfovibrionales 28221|Deltaproteobacteria F Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate folD GO:0003674,GO:0003824,GO:0004477,GO:0004488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006730,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016645,GO:0016646,GO:0016787,GO:0016810,GO:0016814,GO:0019238,GO:0044237,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0055114 1.5.1.5,3.5.4.9 ko:K01491 ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200 M00140,M00377 R01220,R01655 RC00202,RC00578 ko00000,ko00001,ko00002,ko01000 - - - THF_DHG_CYH,THF_DHG_CYH_C k59_1137712_1 1004149.AFOE01000042_gene2697 2.83e-127 377.0 COG0493@1|root,COG0493@2|Bacteria,4NG9R@976|Bacteroidetes,1HWNF@117743|Flavobacteriia 976|Bacteroidetes E NADPH-dependent glutamate synthase beta chain and related gltD - 1.4.1.13,1.4.1.14 ko:K00266 ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 - R00093,R00114,R00248 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - Fer4_20,Pyr_redox_2 k59_65113_1 998674.ATTE01000001_gene3691 7.42e-66 210.0 COG0583@1|root,COG0583@2|Bacteria,1MVA1@1224|Proteobacteria,1RPAJ@1236|Gammaproteobacteria,460V0@72273|Thiotrichales 72273|Thiotrichales K Bacterial regulatory helix-turn-helix protein, lysR family - - - ko:K04761 ko02026,map02026 - - - ko00000,ko00001,ko03000 - - - HTH_1,LysR_substrate k59_1598471_43 1041138.KB890222_gene753 5.14e-37 131.0 2CJKM@1|root,314EI@2|Bacteria,1RGVN@1224|Proteobacteria,2UBK7@28211|Alphaproteobacteria,4BJCA@82115|Rhizobiaceae 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_1598471_45 1122917.KB899685_gene3237 6.27e-101 306.0 COG4422@1|root,COG4422@2|Bacteria,1TPP1@1239|Firmicutes,4HAU8@91061|Bacilli,26V16@186822|Paenibacillaceae 91061|Bacilli S Protein of unknown function (DUF5131) - - - - - - - - - - - - DUF5131 k59_1598471_49 742767.HMPREF9456_03415 7.21e-19 89.0 2DQVJ@1|root,338XS@2|Bacteria,4NWR7@976|Bacteroidetes,2FUTX@200643|Bacteroidia,2315D@171551|Porphyromonadaceae 976|Bacteroidetes - - - - - - - - - - - - - - - k59_1598471_54 999550.KI421507_gene2208 5.44e-22 90.9 2DPEC@1|root,331RJ@2|Bacteria,1N7D6@1224|Proteobacteria,2UFU5@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_468568_1 1545915.JROG01000004_gene2229 4.76e-92 282.0 COG2030@1|root,COG2030@2|Bacteria,1NTV7@1224|Proteobacteria,2UQFU@28211|Alphaproteobacteria,2K8I3@204457|Sphingomonadales 204457|Sphingomonadales I N-terminal half of MaoC dehydratase - - - - - - - - - - - - MaoC_dehydrat_N k59_1768051_1 1459636.NTE_01072 1.4e-38 139.0 COG0667@1|root,arCOG01617@2157|Archaea,41SXK@651137|Thaumarchaeota 651137|Thaumarchaeota C Aldo/keto reductase family - - - - - - - - - - - - Aldo_ket_red k59_1768051_2 436308.Nmar_0725 1.81e-51 168.0 COG2047@1|root,arCOG00348@2157|Archaea,41SFT@651137|Thaumarchaeota 651137|Thaumarchaeota S PAC2 family - - - ko:K07159 - - - - ko00000 - - - PAC2 k59_976198_1 596154.Alide2_4535 2.53e-46 168.0 COG0045@1|root,COG1042@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,1MW98@1224|Proteobacteria,2VNBU@28216|Betaproteobacteria,4AGM2@80864|Comamonadaceae 28216|Betaproteobacteria C CoA binding domain - - - - - - - - - - - - ATP-grasp_5,CoA_binding_2,Succ_CoA_lig k59_129981_2 1415778.JQMM01000001_gene1538 1.37e-61 195.0 COG0164@1|root,COG0164@2|Bacteria,1RA65@1224|Proteobacteria,1RQ4B@1236|Gammaproteobacteria,1J5VG@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids rnhB GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006281,GO:0006298,GO:0006401,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0032299,GO:0032991,GO:0033554,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576 3.1.26.4 ko:K03470 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - RNase_HII k59_1486389_1 1415778.JQMM01000001_gene978 3.16e-75 243.0 COG0497@1|root,COG0497@2|Bacteria,1MUNP@1224|Proteobacteria,1RNPZ@1236|Gammaproteobacteria,1J5DR@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L May be involved in recombinational repair of damaged DNA recN GO:0000724,GO:0000725,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009314,GO:0009432,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0090304,GO:1901360 - ko:K03631 - - - - ko00000,ko03400 - - - AAA_23,SMC_N k59_1428784_1 1229780.BN381_130359 7.01e-68 222.0 COG2072@1|root,COG2072@2|Bacteria,2GJEA@201174|Actinobacteria,3UX3C@52018|unclassified Actinobacteria (class) 201174|Actinobacteria P Flavin-binding monooxygenase-like - - - ko:K10215 ko00627,ko01120,map00627,map01120 - R07836,R07837 RC02100,RC03121 ko00000,ko00001,ko01000 - - - Abhydrolase_1,Abhydrolase_6,FMO-like,NAD_binding_8,Pyr_redox_2,Pyr_redox_3 k59_1203391_1 1449063.JMLS01000001_gene4337 8.87e-12 68.6 COG1506@1|root,COG1506@2|Bacteria,1U5SB@1239|Firmicutes,4HB1A@91061|Bacilli,26VKY@186822|Paenibacillaceae 91061|Bacilli E Dienelactone hydrolase family ytmA - - - - - - - - - - - Peptidase_S9 k59_186777_1 322710.Avin_50650 1.61e-51 176.0 COG4148@1|root,COG4148@2|Bacteria,1MU8K@1224|Proteobacteria,1RQCV@1236|Gammaproteobacteria 1236|Gammaproteobacteria P Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system modC GO:0003674,GO:0003824,GO:0005215,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008509,GO:0015075,GO:0015098,GO:0015103,GO:0015318,GO:0015399,GO:0015405,GO:0015412,GO:0015689,GO:0015698,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022857,GO:0034220,GO:0042623,GO:0042626,GO:0043225,GO:0043492,GO:0051179,GO:0051234,GO:0055085,GO:0098656,GO:0099133 3.6.3.29 ko:K02017 ko02010,map02010 M00189 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.8 - - ABC_tran,TOBE k59_1259420_1 397278.JOJN01000003_gene1874 1.59e-60 206.0 COG1523@1|root,COG1523@2|Bacteria,2GJ00@201174|Actinobacteria,4DN1Q@85009|Propionibacteriales 201174|Actinobacteria G Carbohydrate-binding module 48 (Isoamylase N-terminal domain) - - 3.2.1.68 ko:K01214 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R09995,R11261 - ko00000,ko00001,ko00002,ko01000 - CBM48,GH13 - Alpha-amylase,CBM_48 k59_1259420_2 1123320.KB889697_gene9028 1.16e-24 103.0 COG1878@1|root,COG1878@2|Bacteria,2GUSA@201174|Actinobacteria 201174|Actinobacteria S cyclase family - - - - - - - - - - - - Cyclase k59_1768077_1 1122137.AQXF01000007_gene3620 7.75e-216 616.0 COG1082@1|root,COG1082@2|Bacteria,1NNTS@1224|Proteobacteria,2U06E@28211|Alphaproteobacteria 28211|Alphaproteobacteria G Glycosyl-hydrolase 97 C-terminal, oligomerisation - - 3.2.1.20 ko:K01187 ko00052,ko00500,ko01100,map00052,map00500,map01100 - R00028,R00801,R00802,R06087,R06088 RC00028,RC00049,RC00077 ko00000,ko00001,ko01000 - GH31 - GH97_C,GH97_N,Glyco_hydro_97 k59_1259422_1 436308.Nmar_0324 5.18e-91 271.0 COG0522@1|root,arCOG04239@2157|Archaea,41SN3@651137|Thaumarchaeota 651137|Thaumarchaeota J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit rps4 - - ko:K02986 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - S4 k59_186783_1 1000565.METUNv1_01110 6.85e-05 45.1 COG1716@1|root,COG2114@1|root,COG1716@2|Bacteria,COG2114@2|Bacteria,1NAJG@1224|Proteobacteria,2VJW8@28216|Betaproteobacteria,2KWRJ@206389|Rhodocyclales 206389|Rhodocyclales T Forkhead associated domain - - - - - - - - - - - - FHA,Guanylate_cyc k59_186783_2 1049564.TevJSym_ab01230 1.21e-93 284.0 COG2242@1|root,COG2242@2|Bacteria,1R79F@1224|Proteobacteria,1RY3Z@1236|Gammaproteobacteria,1J8AJ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H protein methyltransferase activity - - - - - - - - - - - - Methyltransf_11,Methyltransf_25 k59_130000_1 1476583.DEIPH_ctg055orf0025 2.82e-27 109.0 COG4867@1|root,COG4867@2|Bacteria,1WJ6Y@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus S protein with a von Willebrand factor type A (vWA) domain - - - ko:K07114 - - - - ko00000,ko02000 1.A.13.2.2,1.A.13.2.3 - - VWA_2 k59_638178_1 446471.Xcel_2128 3.77e-47 164.0 COG1249@1|root,COG1249@2|Bacteria,2I6E8@201174|Actinobacteria 201174|Actinobacteria C Pyridine nucleotide-disulphide oxidoreductase - - - - - - - - - - - - - k59_751050_1 1232437.KL662033_gene2680 4.36e-17 86.3 COG0683@1|root,COG0683@2|Bacteria,1R8IG@1224|Proteobacteria,42N7H@68525|delta/epsilon subdivisions,2WIUQ@28221|Deltaproteobacteria,2MHTC@213118|Desulfobacterales 28221|Deltaproteobacteria E Periplasmic binding protein - - - ko:K07121 - - - - ko00000 - - - LppC,Peripla_BP_6,TPR_6 k59_242543_1 566466.NOR53_3413 5.55e-34 137.0 COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,1T234@1236|Gammaproteobacteria 1236|Gammaproteobacteria K Adenylate cyclase - - - - - - - - - - - - TPR_16 k59_1259435_1 3712.Bo3g064330.1 1.04e-17 81.3 2C3SF@1|root,2S2UC@2759|Eukaryota,37VV6@33090|Viridiplantae,3GJGF@35493|Streptophyta 3712.Bo3g064330.1|- S protein Sb1514s002020 source - - - - - - - - - - - - - k59_1598516_1 1207063.P24_09931 4.17e-100 300.0 COG0714@1|root,COG0714@2|Bacteria,1MV5I@1224|Proteobacteria,2TREB@28211|Alphaproteobacteria,2JQDG@204441|Rhodospirillales 204441|Rhodospirillales S AAA domain (dynein-related subfamily) - - - - - - - - - - - - AAA,AAA_5 k59_1768091_1 1396141.BATP01000047_gene3950 3.04e-29 108.0 COG0776@1|root,COG0776@2|Bacteria,46XH3@74201|Verrucomicrobia,2IVWK@203494|Verrucomicrobiae 203494|Verrucomicrobiae L Bacterial DNA-binding protein - - - - - - - - - - - - Bac_DNA_binding k59_1768091_2 247639.MGP2080_00440 5.62e-06 47.4 COG4103@1|root,COG4103@2|Bacteria,1N6YZ@1224|Proteobacteria,1SD1K@1236|Gammaproteobacteria 1236|Gammaproteobacteria S protein conserved in bacteria - - - - - - - - - - - - TerB k59_1598517_1 589865.DaAHT2_1485 1.6e-26 112.0 COG0769@1|root,COG0769@2|Bacteria,1MU6P@1224|Proteobacteria,42NKY@68525|delta/epsilon subdivisions,2WJJG@28221|Deltaproteobacteria,2MHKD@213118|Desulfobacterales 28221|Deltaproteobacteria M Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan murE GO:0000270,GO:0003674,GO:0003824,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008765,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0030203,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 6.3.2.13 ko:K01928 ko00300,ko00550,map00300,map00550 - R02788 RC00064,RC00090 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_582782_1 1144319.PMI16_00261 4.13e-28 118.0 COG5000@1|root,COG5001@1|root,COG5000@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VHPI@28216|Betaproteobacteria,475S0@75682|Oxalobacteraceae 28216|Betaproteobacteria T Double sensory domain of two-component sensor kinase - - - - - - - - - - - - EAL,GGDEF,HAMP,dCache_3 k59_357703_1 644107.SL1157_0309 1.81e-59 205.0 COG0668@1|root,COG0668@2|Bacteria,1MY0I@1224|Proteobacteria,2TSIN@28211|Alphaproteobacteria,4NBRC@97050|Ruegeria 28211|Alphaproteobacteria M Mechanosensitive ion channel - - - ko:K22044 - - - - ko00000,ko02000 1.A.23.3 - - MS_channel k59_695865_1 1265313.HRUBRA_02417 2.54e-65 219.0 COG0659@1|root,COG0659@2|Bacteria,1MVWV@1224|Proteobacteria,1RMCN@1236|Gammaproteobacteria 1236|Gammaproteobacteria P COG0659 Sulfate permease and related transporters (MFS superfamily) - - - ko:K03321 - - - - ko00000,ko02000 2.A.53.3 - - STAS,Sulfate_transp k59_1147692_1 247634.GPB2148_433 1.13e-80 247.0 COG0169@1|root,COG0169@2|Bacteria,1MVH4@1224|Proteobacteria,1RPB7@1236|Gammaproteobacteria,1J5D3@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) aroE GO:0000166,GO:0003674,GO:0003824,GO:0004764,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019632,GO:0019752,GO:0032787,GO:0036094,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0097159,GO:1901265,GO:1901363,GO:1901576,GO:1901615 1.1.1.25 ko:K00014 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02413 RC00206 ko00000,ko00001,ko00002,ko01000 - - iAPECO1_1312.APECO1_3165,iECOK1_1307.ECOK1_3701,iECS88_1305.ECS88_3669,iECUMN_1333.ECUMN_3755,iSBO_1134.SBO_3275,iUMN146_1321.UM146_16315,iUTI89_1310.UTI89_C3726 Shikimate_DH,Shikimate_dh_N k59_525879_1 754476.Q7A_8 2.32e-25 99.0 COG0848@1|root,COG0848@2|Bacteria,1MZ6M@1224|Proteobacteria,1S8RS@1236|Gammaproteobacteria,46135@72273|Thiotrichales 72273|Thiotrichales U Biopolymer transport protein ExbD TolR tolR - - ko:K03560 - - - - ko00000,ko02000 1.A.30.2.2 - - ExbD k59_525879_2 1410676.JNKL01000032_gene1666 1.4e-46 160.0 COG0811@1|root,COG0811@2|Bacteria,1NCWW@1224|Proteobacteria,1RMD4@1236|Gammaproteobacteria,1Y3N0@135624|Aeromonadales 135624|Aeromonadales U MotA/TolQ/ExbB proton channel family tolQ - - ko:K03562 ko01120,map01120 - - - ko00000,ko02000 1.A.30.2.2 - - MotA_ExbB k59_1260697_1 190486.XAC3617 7.49e-06 48.1 COG1956@1|root,COG1956@2|Bacteria,1RDBM@1224|Proteobacteria,1S6QU@1236|Gammaproteobacteria,1X616@135614|Xanthomonadales 135614|Xanthomonadales T Diguanylate cyclase - - 1.8.4.14 ko:K08968 ko00270,map00270 - R02025 RC00639 ko00000,ko00001,ko01000 - - - GAF_2 k59_1260697_2 722419.PH505_ad00190 4.02e-18 85.1 COG0123@1|root,COG0123@2|Bacteria,1MU7P@1224|Proteobacteria,1RPVZ@1236|Gammaproteobacteria,2Q0R0@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria BQ COG0123 Deacetylases, including yeast histone deacetylase and acetoin utilization protein - - - - - - - - - - - - Hist_deacetyl k59_413403_1 649764.HMPREF0762_01849 9.89e-14 75.9 COG1158@1|root,COG1158@2|Bacteria,2GIWY@201174|Actinobacteria,4CU9T@84998|Coriobacteriia 84998|Coriobacteriia K Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template rho - - ko:K03628 ko03018,map03018 - - - ko00000,ko00001,ko03019,ko03021 - - - ATP-synt_ab,Rho_N,Rho_RNA_bind,SAP k59_977605_1 1265503.KB905160_gene2871 2.82e-83 275.0 28HKI@1|root,2Z7VC@2|Bacteria,1MW0I@1224|Proteobacteria,1RQ5H@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_582794_1 436308.Nmar_0800 1.88e-53 169.0 COG0093@1|root,arCOG04095@2157|Archaea,41SHG@651137|Thaumarchaeota 651137|Thaumarchaeota J Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome rpl14 - - ko:K02874 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L14 k59_582794_2 1459636.NTE_01826 2.21e-24 98.6 COG0198@1|root,arCOG04094@2157|Archaea,41SSS@651137|Thaumarchaeota 651137|Thaumarchaeota J Located at the polypeptide exit tunnel on the outside of the subunit rpl24 - - ko:K02895 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L26 k59_525892_1 519989.ECTPHS_02651 6.89e-51 168.0 COG2077@1|root,COG2077@2|Bacteria,1RAJ9@1224|Proteobacteria,1S263@1236|Gammaproteobacteria,1WX7S@135613|Chromatiales 135613|Chromatiales O Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides tpx - 1.11.1.15 ko:K11065 - - - - ko00000,ko01000 - - - Redoxin k59_809473_1 1424334.W822_13620 2.09e-46 160.0 COG0468@1|root,COG0468@2|Bacteria,1MU3C@1224|Proteobacteria,2VHNA@28216|Betaproteobacteria,3T255@506|Alcaligenaceae 28216|Betaproteobacteria L Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage recA - - ko:K03553 ko03440,map03440 M00729 - - ko00000,ko00001,ko00002,ko03400 - - - RecA k59_809473_2 1439940.BAY1663_00514 3.77e-18 80.9 COG2137@1|root,COG2137@2|Bacteria,1N6P6@1224|Proteobacteria,1SCMF@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Regulatory protein recX recX GO:0003674,GO:0005488,GO:0005515,GO:0006282,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0019219,GO:0019222,GO:0019899,GO:0030234,GO:0031323,GO:0031668,GO:0033554,GO:0043086,GO:0044092,GO:0048583,GO:0050789,GO:0050790,GO:0050794,GO:0050896,GO:0051052,GO:0051171,GO:0051716,GO:0060255,GO:0065007,GO:0065009,GO:0071496,GO:0080090,GO:0080134,GO:0080135,GO:0098772,GO:2001020 - ko:K03565 - - - - ko00000,ko03400 - - - RecX k59_1712781_1 1178825.ALIH01000006_gene1391 1.12e-73 226.0 2AA7H@1|root,30ZGJ@2|Bacteria,4NNWC@976|Bacteroidetes,1I2H8@117743|Flavobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_1712781_2 1121912.AUHD01000014_gene1055 1.93e-30 117.0 28HZ9@1|root,2Z84F@2|Bacteria,4NGBH@976|Bacteroidetes,1HZRV@117743|Flavobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_413421_1 1121949.AQXT01000002_gene1410 6.23e-66 218.0 COG1804@1|root,COG1804@2|Bacteria,1MX0I@1224|Proteobacteria,2U2RY@28211|Alphaproteobacteria,43ZKU@69657|Hyphomonadaceae 28211|Alphaproteobacteria C CoA-transferase family III - - - - - - - - - - - - CoA_transf_3 k59_1374479_1 1522072.IL54_0635 5.58e-41 146.0 COG0318@1|root,COG0318@2|Bacteria,1NTR7@1224|Proteobacteria,2UPRR@28211|Alphaproteobacteria,2K3JS@204457|Sphingomonadales 204457|Sphingomonadales IQ AMP-binding enzyme - - - ko:K00666 - - - - ko00000,ko01000,ko01004 - - - AMP-binding,AMP-binding_C k59_1204534_1 876044.IMCC3088_1280 8.92e-116 342.0 COG0448@1|root,COG0448@2|Bacteria,1MVTC@1224|Proteobacteria,1RP04@1236|Gammaproteobacteria,1J9TH@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans glgC - 2.7.7.27 ko:K00975 ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026 M00565 R00948 RC00002 ko00000,ko00001,ko00002,ko01000 - - - NTP_transferase k59_1374480_1 1046627.BZARG_428 1.32e-37 144.0 28IHD@1|root,2Z8IK@2|Bacteria,4NF9V@976|Bacteroidetes,1HY20@117743|Flavobacteriia 976|Bacteroidetes S Domain of unknown function (DUF4270) - - - - - - - - - - - - DUF4270 k59_1036100_1 1380391.JIAS01000012_gene4238 6.28e-48 172.0 COG0747@1|root,COG0747@2|Bacteria,1MXQ4@1224|Proteobacteria,2TTIZ@28211|Alphaproteobacteria,2JQX9@204441|Rhodospirillales 204441|Rhodospirillales E Bacterial extracellular solute-binding proteins, family 5 Middle - - - - - - - - - - - - SBP_bac_5 k59_866428_1 1089553.Tph_c27560 7.38e-81 251.0 COG0216@1|root,COG0216@2|Bacteria,1TQ7V@1239|Firmicutes,248CN@186801|Clostridia,42FEW@68295|Thermoanaerobacterales 186801|Clostridia J Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA prfA - - ko:K02835 - - - - ko00000,ko03012 - - - PCRF,RF-1 k59_243868_1 648757.Rvan_0788 4.32e-54 185.0 COG1593@1|root,COG1593@2|Bacteria,1MUQE@1224|Proteobacteria,2TSSE@28211|Alphaproteobacteria,3N7IU@45401|Hyphomicrobiaceae 28211|Alphaproteobacteria G Malonyl-CoA decarboxylase matA - 4.1.1.9 ko:K01578 ko00410,ko00640,ko01100,ko04146,ko04152,map00410,map00640,map01100,map04146,map04152 - R00233 RC00040 ko00000,ko00001,ko01000 - - - MCD,MCD_N k59_75520_1 1219045.BV98_003977 1.26e-72 230.0 COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2TR7Q@28211|Alphaproteobacteria,2K3NH@204457|Sphingomonadales 204457|Sphingomonadales C CoA-transferase family III - - - - - - - - - - - - CoA_transf_3 k59_1599932_1 1229909.NSED_06360 2.17e-65 201.0 COG0251@1|root,arCOG01630@2157|Archaea,41T4N@651137|Thaumarchaeota 651137|Thaumarchaeota J YjgF/chorismate_mutase-like, putative endoribonuclease - - - - - - - - - - - - YjgF_endoribonc k59_243878_1 629773.AORY01000015_gene1279 4.82e-138 399.0 COG0451@1|root,COG0451@2|Bacteria,1MU7J@1224|Proteobacteria,2TSIP@28211|Alphaproteobacteria,2K0VH@204457|Sphingomonadales 204457|Sphingomonadales M epimerase dehydratase - - 5.1.3.6 ko:K08679 ko00520,ko01100,map00520,map01100 - R01385 RC00289 ko00000,ko00001,ko01000 - - - Epimerase,GDP_Man_Dehyd k59_809488_1 1122137.AQXF01000001_gene3155 1.46e-99 307.0 COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,2TR6Q@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Belongs to the DEAD box helicase family rhlE - 3.6.4.13 ko:K11927 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - DEAD,Helicase_C k59_582814_1 1202532.FF52_22309 1.64e-37 144.0 COG3177@1|root,COG3177@2|Bacteria,4NR8T@976|Bacteroidetes,1IDPT@117743|Flavobacteriia,2NYXI@237|Flavobacterium 976|Bacteroidetes M Domain of unknown function (DUF4157) - - - - - - - - - - - - DUF4157 k59_1769412_3 323261.Noc_1773 5.46e-24 96.7 COG1499@1|root,COG1499@2|Bacteria,1RD49@1224|Proteobacteria,1S4E9@1236|Gammaproteobacteria 1236|Gammaproteobacteria J ribosomal large subunit export from nucleus - - - - - - - - - - - - NMD3 k59_1204550_1 1121033.AUCF01000003_gene3324 2.52e-12 66.2 COG0438@1|root,COG0438@2|Bacteria,1R4Q9@1224|Proteobacteria,2TUGJ@28211|Alphaproteobacteria,2JR4M@204441|Rhodospirillales 204441|Rhodospirillales M Glycosyl transferases group 1 - - - - - - - - - - - - Glycos_transf_1 k59_1204550_2 279714.FuraDRAFT_3773 9.39e-36 135.0 COG0438@1|root,COG0438@2|Bacteria,1MVKK@1224|Proteobacteria,2VMU1@28216|Betaproteobacteria,2KS2V@206351|Neisseriales 206351|Neisseriales M Glycosyl transferases group 1 - - - - - - - - - - - - Glyco_transf_4,Glycos_transf_1 k59_1036139_1 436308.Nmar_0058 4.04e-57 183.0 COG2243@1|root,arCOG00648@2157|Archaea,41SGJ@651137|Thaumarchaeota 651137|Thaumarchaeota H Tetrapyrrole (Corrin/Porphyrin) Methylases - - 2.1.1.130,2.1.1.151 ko:K03394 ko00860,ko01100,map00860,map01100 - R03948,R05808 RC00003,RC01035,RC01662 ko00000,ko00001,ko01000 - - - TP_methylase k59_1036139_2 1229909.NSED_09915 1.48e-28 107.0 COG2242@1|root,arCOG00977@2157|Archaea,41SID@651137|Thaumarchaeota 651137|Thaumarchaeota J Catalyzes the methylation of C-15 in cobalt-precorrin-6B followed by the decarboxylation of C-12 to form cobalt-precorrin- 7 cbiT - 2.1.1.196 ko:K02191 ko00860,map00860 - R05813,R07774 RC00003,RC02052,RC02054 ko00000,ko00001,ko01000 - - - Methyltransf_31 k59_866445_2 1245469.S58_44200 5.97e-12 65.5 COG4608@1|root,COG4608@2|Bacteria,1NU4K@1224|Proteobacteria,2TQTV@28211|Alphaproteobacteria,3JVVP@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria P Oligopeptide/dipeptide transporter, C-terminal region - - - ko:K02032,ko:K10823 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00239,M00439 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 - - ABC_tran,oligo_HPY k59_1430192_1 552467.XP_003193558.1 2.01e-31 124.0 COG1304@1|root,KOG0538@2759|Eukaryota,38BCT@33154|Opisthokonta,3NTYS@4751|Fungi,3UXVJ@5204|Basidiomycota,3VDJN@5234|Tremellales 4751|Fungi C FMN-dependent dehydrogenase - - 1.1.3.15,1.13.12.4 ko:K00467,ko:K11517 ko00620,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko04146,map00620,map00630,map01100,map01110,map01120,map01130,map01200,map04146 M00532 R00319,R00475 RC00042,RC01312 ko00000,ko00001,ko00002,ko01000 - - - FMN_dh k59_141967_2 292415.Tbd_2149 1.75e-15 74.3 COG2755@1|root,COG2755@2|Bacteria,1RHDZ@1224|Proteobacteria,2WEFV@28216|Betaproteobacteria 28216|Betaproteobacteria E PFAM lipolytic protein G-D-S-L family - - 3.1.2.20 ko:K01073 - - - - ko00000,ko01000 - - - Lipase_GDSL_2 k59_877796_1 1229909.NSED_07365 2.65e-158 455.0 COG1301@1|root,arCOG04335@2157|Archaea 2157|Archaea C COG1301 Na H -dicarboxylate symporters gltP GO:0001504,GO:0001505,GO:0003333,GO:0003674,GO:0005215,GO:0005283,GO:0005310,GO:0005326,GO:0005342,GO:0005343,GO:0005416,GO:0005488,GO:0005515,GO:0006810,GO:0006811,GO:0006812,GO:0006814,GO:0006820,GO:0006821,GO:0006835,GO:0006836,GO:0006865,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0009987,GO:0015075,GO:0015077,GO:0015081,GO:0015103,GO:0015108,GO:0015171,GO:0015172,GO:0015179,GO:0015183,GO:0015291,GO:0015293,GO:0015294,GO:0015318,GO:0015370,GO:0015556,GO:0015672,GO:0015698,GO:0015711,GO:0015740,GO:0015800,GO:0015807,GO:0015849,GO:0016043,GO:0022607,GO:0022804,GO:0022857,GO:0022890,GO:0030001,GO:0034220,GO:0035725,GO:0042802,GO:0043090,GO:0043933,GO:0044085,GO:0046873,GO:0046942,GO:0046943,GO:0051179,GO:0051234,GO:0051259,GO:0051260,GO:0055085,GO:0065003,GO:0065007,GO:0065008,GO:0070206,GO:0070207,GO:0070778,GO:0071702,GO:0071705,GO:0071840,GO:0089718,GO:0098655,GO:0098656,GO:0098657,GO:0098660,GO:0098661,GO:0098662,GO:0098739,GO:0140009,GO:1902475,GO:1902476,GO:1903825,GO:1905039 - ko:K07862 - - - - ko00000,ko02000 2.A.23.4 - - SDF k59_254785_1 158500.BV97_02544 5.39e-60 206.0 COG4772@1|root,COG4772@2|Bacteria,1NTC4@1224|Proteobacteria,2U3CZ@28211|Alphaproteobacteria,2K50K@204457|Sphingomonadales 204457|Sphingomonadales P TonB dependent receptor - - - - - - - - - - - - Plug,TonB_dep_Rec k59_141977_1 392499.Swit_5197 2.7e-28 112.0 COG3547@1|root,COG3547@2|Bacteria,1MW0N@1224|Proteobacteria,2TUGE@28211|Alphaproteobacteria,2K3NU@204457|Sphingomonadales 204457|Sphingomonadales L Protein involved in DNA binding and transposition, DNA-mediated - - - ko:K07486 - - - - ko00000 - - - DEDD_Tnp_IS110,Transposase_20 k59_760711_1 1122137.AQXF01000005_gene1307 6.45e-140 412.0 COG0405@1|root,COG0405@2|Bacteria,1MUV6@1224|Proteobacteria,2TR49@28211|Alphaproteobacteria 28211|Alphaproteobacteria E gamma-glutamyltransferase ggt - 2.3.2.2,3.4.19.13 ko:K00681 ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100 - R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935 RC00064,RC00090,RC00096 ko00000,ko00001,ko01000,ko01002 - - - G_glu_transpept k59_312666_2 314278.NB231_11949 3e-40 141.0 COG3124@1|root,COG3124@2|Bacteria,1MZ59@1224|Proteobacteria,1S9IZ@1236|Gammaproteobacteria,1X1G0@135613|Chromatiales 135613|Chromatiales S Acyl carrier protein phosphodiesterase - - - - - - - - - - - - ACP_PD k59_141981_1 1205680.CAKO01000026_gene4555 3.75e-06 47.0 COG0346@1|root,COG0346@2|Bacteria,1RHIV@1224|Proteobacteria,2TR4K@28211|Alphaproteobacteria,2JUPC@204441|Rhodospirillales 204441|Rhodospirillales E Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - - - - - - - - - - Glyoxalase k59_141981_2 754477.Q7C_658 8.11e-48 156.0 COG0640@1|root,COG0640@2|Bacteria,1MZAU@1224|Proteobacteria,1SASR@1236|Gammaproteobacteria,463JH@72273|Thiotrichales 72273|Thiotrichales K helix_turn_helix, Arsenical Resistance Operon Repressor - - - ko:K03892 - - - - ko00000,ko03000 - - - HTH_20 k59_877802_1 1122137.AQXF01000002_gene484 2.51e-49 166.0 COG3173@1|root,COG3173@2|Bacteria,1MWAK@1224|Proteobacteria,2TT2N@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Aminoglycoside phosphotransferase - - - - - - - - - - - - APH k59_877802_2 1122137.AQXF01000002_gene482 4.42e-173 486.0 COG1946@1|root,COG1946@2|Bacteria,1MV9R@1224|Proteobacteria,2TRFD@28211|Alphaproteobacteria 28211|Alphaproteobacteria I acyl-CoA thioesterase - - - ko:K10805 ko01040,map01040 - - - ko00000,ko00001,ko01000,ko01004 - - - 4HBT_3 k59_877802_3 1122137.AQXF01000002_gene481 5.59e-142 405.0 COG0235@1|root,COG0235@2|Bacteria,1MWP9@1224|Proteobacteria,2TRMV@28211|Alphaproteobacteria 28211|Alphaproteobacteria G COG0235, Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases MA20_15730 - - - - - - - - - - - Aldolase_II k59_1326241_1 1096930.L284_02555 8.43e-98 296.0 COG0845@1|root,COG0845@2|Bacteria,1MU78@1224|Proteobacteria,2TSWK@28211|Alphaproteobacteria,2K12P@204457|Sphingomonadales 204457|Sphingomonadales M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - - - - - - - - - - HlyD_D23 k59_1100416_1 1131462.DCF50_p615 3.55e-45 155.0 COG0307@1|root,COG0307@2|Bacteria,1V1EP@1239|Firmicutes,24FVK@186801|Clostridia,260I1@186807|Peptococcaceae 186801|Clostridia H TIGRFAM riboflavin synthase, alpha subunit ribE - 2.5.1.9 ko:K00793 ko00740,ko01100,ko01110,map00740,map01100,map01110 M00125 R00066 RC00958,RC00960 ko00000,ko00001,ko00002,ko01000 - - - Lum_binding k59_369510_1 156578.ATW7_16019 5.44e-80 251.0 COG2855@1|root,COG2855@2|Bacteria,1MVIP@1224|Proteobacteria,1RPSG@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Belongs to the UPF0324 family - - - - - - - - - - - - Cons_hypoth698 k59_761607_2 1122605.KB893643_gene788 5.88e-17 81.3 COG1595@1|root,COG1595@2|Bacteria,4NMVF@976|Bacteroidetes,1IT30@117747|Sphingobacteriia 976|Bacteroidetes K DNA-templated transcription, initiation - - - - - - - - - - - - SatD k59_931426_2 1123514.KB905902_gene308 2.6e-16 76.6 COG3671@1|root,COG3671@2|Bacteria,1MZMW@1224|Proteobacteria,1S8EV@1236|Gammaproteobacteria,461DB@72273|Thiotrichales 72273|Thiotrichales S membrane - - - - - - - - - - - - - k59_370742_3 1239962.C943_01662 5.4e-26 100.0 COG3743@1|root,COG3743@2|Bacteria,4NQGZ@976|Bacteroidetes,47QTW@768503|Cytophagia 976|Bacteroidetes S Domain of unknown function (DUF4332) - - - - - - - - - - - - DUF4332,HHH_5 k59_142871_2 596320.NEIFL0001_0830 6.89e-47 155.0 COG0251@1|root,COG0251@2|Bacteria,1MZ3J@1224|Proteobacteria,2VRQ3@28216|Betaproteobacteria,2KR3Y@206351|Neisseriales 206351|Neisseriales J endoribonuclease L-PSP - - - - - - - - - - - - Ribonuc_L-PSP k59_142871_3 2340.JV46_16090 3.72e-46 169.0 COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,1RN3H@1236|Gammaproteobacteria,1J53A@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance spoT GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0007154,GO:0008150,GO:0008152,GO:0008728,GO:0008893,GO:0009116,GO:0009117,GO:0009119,GO:0009150,GO:0009259,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0015949,GO:0015969,GO:0016020,GO:0016740,GO:0016772,GO:0016778,GO:0016787,GO:0016788,GO:0016794,GO:0019637,GO:0019693,GO:0030312,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0033865,GO:0033875,GO:0034032,GO:0034035,GO:0034641,GO:0042278,GO:0042578,GO:0042594,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046128,GO:0046483,GO:0050896,GO:0051716,GO:0055086,GO:0071496,GO:0071704,GO:0071944,GO:0072521,GO:1901068,GO:1901135,GO:1901360,GO:1901564,GO:1901657 2.7.6.5,3.1.7.2 ko:K00951,ko:K01139 ko00230,map00230 - R00336,R00429 RC00002,RC00078 ko00000,ko00001,ko01000,ko03009 - - iECNA114_1301.ECNA114_3794,iECOK1_1307.ECOK1_4092,iECP_1309.ECP_3748,iECS88_1305.ECS88_4065,iECSF_1327.ECSF_3486,iLF82_1304.LF82_2165,iNRG857_1313.NRG857_18145,iUMN146_1321.UM146_18405,iUTI89_1310.UTI89_C4195,ic_1306.c4475 ACT_4,HD_4,RelA_SpoT,TGS k59_198361_1 1156937.MFUM_990011 1.15e-30 121.0 COG0787@1|root,COG0787@2|Bacteria,46SM1@74201|Verrucomicrobia,37GBR@326457|unclassified Verrucomicrobia 74201|Verrucomicrobia E Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids alr - 5.1.1.1 ko:K01775 ko00473,ko01100,ko01502,map00473,map01100,map01502 - R00401 RC00285 ko00000,ko00001,ko01000,ko01011 - - - Ala_racemase_C,Ala_racemase_N k59_534649_1 426355.Mrad2831_1620 1.44e-36 136.0 COG4307@1|root,COG4307@2|Bacteria,1MW31@1224|Proteobacteria,2TRR9@28211|Alphaproteobacteria,1JR6J@119045|Methylobacteriaceae 28211|Alphaproteobacteria S Putative zinc-binding metallo-peptidase - - - - - - - - - - - - Peptidase_Mx,zinc-ribbon_6 k59_818736_1 1229909.NSED_07380 2.01e-15 76.6 arCOG08738@1|root,arCOG08738@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - SHOCT k59_1612378_1 999541.bgla_1g22840 4.12e-41 136.0 COG1923@1|root,COG1923@2|Bacteria,1MZM1@1224|Proteobacteria,2VTXK@28216|Betaproteobacteria,1K8J4@119060|Burkholderiaceae 28216|Betaproteobacteria J RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs hfq - - ko:K03666 ko02024,ko03018,ko05111,map02024,map03018,map05111 - - - ko00000,ko00001,ko03019,ko03036 - - - Hfq k59_1612378_2 62928.azo1036 2.9e-17 80.1 COG0082@1|root,COG0082@2|Bacteria,1MU98@1224|Proteobacteria,2VJA4@28216|Betaproteobacteria,2KUQ4@206389|Rhodocyclales 206389|Rhodocyclales E Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system aroC - 4.2.3.5 ko:K01736 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R01714 RC00586 ko00000,ko00001,ko00002,ko01000 - - - Chorismate_synt k59_1387259_1 1392489.JPOL01000002_gene382 4.32e-89 285.0 COG0577@1|root,COG0577@2|Bacteria,4NDUK@976|Bacteroidetes,1HX0V@117743|Flavobacteriia,2XK1R@283735|Leeuwenhoekiella 976|Bacteroidetes V MacB-like periplasmic core domain - - - - - - - - - - - - FtsX,MacB_PCD k59_314018_1 1227360.C176_05702 1.74e-05 51.6 COG1876@1|root,COG1876@2|Bacteria,1V69M@1239|Firmicutes,4HHJT@91061|Bacilli,26EZ5@186818|Planococcaceae 91061|Bacilli M D-alanyl-D-alanine carboxypeptidase cwlK - - ko:K17733 - - - - ko00000,ko01000,ko01002,ko01011 - - - Peptidase_M15_4 k59_31222_1 1411685.U062_01892 7.12e-32 127.0 COG0616@1|root,COG0616@2|Bacteria,1MUXE@1224|Proteobacteria,1RNYW@1236|Gammaproteobacteria,1J4TN@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria OU COG0616 Periplasmic serine proteases (ClpP class) sppA GO:0003674,GO:0003824,GO:0004175,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006465,GO:0006508,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009987,GO:0010467,GO:0016020,GO:0016021,GO:0016485,GO:0016787,GO:0019538,GO:0031224,GO:0031226,GO:0034641,GO:0043170,GO:0043603,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0051604,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564 - ko:K04773 - - - - ko00000,ko01000,ko01002 - - - Peptidase_S49 k59_31222_2 1286093.C266_17200 3.26e-14 72.0 COG0593@1|root,COG0593@2|Bacteria,1MVW6@1224|Proteobacteria,2VSFD@28216|Betaproteobacteria,1K0WU@119060|Burkholderiaceae 28216|Betaproteobacteria L Belongs to the DnaA family hda - - ko:K10763 - - - - ko00000,ko03032 - - - Bac_DnaA k59_1048253_1 1122137.AQXF01000005_gene1295 4.23e-67 212.0 COG0412@1|root,COG0412@2|Bacteria,1MW7S@1224|Proteobacteria,2TTPH@28211|Alphaproteobacteria 28211|Alphaproteobacteria Q Dienelactone hydrolase - - 3.1.1.45 ko:K01061 ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130 - R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222 RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686 ko00000,ko00001,ko01000 - - - DLH k59_1048253_2 1038860.AXAP01000007_gene6029 1.62e-13 70.9 28SWB@1|root,2ZF5V@2|Bacteria,1RDU2@1224|Proteobacteria,2UAVH@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Protein of unknown function (DUF2971) - - - - - - - - - - - - DUF2971 k59_761643_1 215803.DB30_7689 1.4e-17 91.3 COG0243@1|root,COG0437@1|root,COG0243@2|Bacteria,COG0437@2|Bacteria,1MU1B@1224|Proteobacteria,42NEG@68525|delta/epsilon subdivisions,2WKHA@28221|Deltaproteobacteria,2YTUQ@29|Myxococcales 28221|Deltaproteobacteria C 4Fe-4S dicluster domain actB - - ko:K00184 - - - - ko00000 5.A.3 - - Fer4_7,Molybdop_Fe4S4,Molybdopterin,Molydop_binding k59_142893_1 1229909.NSED_09460 1.73e-13 66.6 COG0589@1|root,arCOG02053@2157|Archaea,41T7V@651137|Thaumarchaeota 651137|Thaumarchaeota T Universal stress protein - - - - - - - - - - - - Usp k59_142893_2 981336.F944_01389 1.15e-15 76.3 COG0517@1|root,COG0517@2|Bacteria,1N0H3@1224|Proteobacteria,1S6HB@1236|Gammaproteobacteria,3NNMS@468|Moraxellaceae 1236|Gammaproteobacteria S Domain in cystathionine beta-synthase and other proteins. - - - - - - - - - - - - CBS k59_1777665_1 762948.HMPREF0733_10310 2.03e-38 132.0 COG0049@1|root,COG0049@2|Bacteria,2GMVW@201174|Actinobacteria,1W87Y@1268|Micrococcaceae 201174|Actinobacteria J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA rpsG GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030312,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02992 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S7 k59_1777665_2 888050.HMPREF9004_0527 1.39e-47 155.0 COG0048@1|root,COG0048@2|Bacteria,2IHUF@201174|Actinobacteria,4D5TR@85005|Actinomycetales 201174|Actinobacteria J Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit rpsL GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02950 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosom_S12_S23 k59_88388_1 635013.TherJR_2111 1.75e-08 57.8 COG1639@1|root,COG1639@2|Bacteria,1TPRT@1239|Firmicutes,249CG@186801|Clostridia,262X5@186807|Peptococcaceae 186801|Clostridia T PFAM HDOD domain - - - - - - - - - - - - HDOD,Response_reg k59_1612403_1 1123269.NX02_13735 5.76e-19 84.3 COG0119@1|root,COG0119@2|Bacteria,1MUMX@1224|Proteobacteria,2TT1R@28211|Alphaproteobacteria,2K262@204457|Sphingomonadales 204457|Sphingomonadales E HMGL-like - - 4.1.3.4 ko:K01640 ko00072,ko00280,ko00281,ko00650,ko01100,ko04146,map00072,map00280,map00281,map00650,map01100,map04146 M00036,M00088 R01360,R08090 RC00502,RC00503,RC01118,RC01946 ko00000,ko00001,ko00002,ko01000 - - - HMGL-like k59_1612403_2 195250.CM001776_gene1131 2.18e-81 256.0 COG0044@1|root,COG0044@2|Bacteria,1G2H3@1117|Cyanobacteria,1GYM9@1129|Synechococcus 1117|Cyanobacteria F dihydroorotase - - 3.5.2.2,3.5.2.5 ko:K01464,ko:K01466 ko00230,ko00240,ko00410,ko00770,ko00983,ko01100,ko01120,map00230,map00240,map00410,map00770,map00983,map01100,map01120 M00046,M00546 R02269,R02425,R03055,R08227 RC00632,RC00680 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Amidohydro_1 k59_370794_1 1458427.BAWN01000020_gene1221 1.01e-85 266.0 COG1271@1|root,COG1271@2|Bacteria,1MV60@1224|Proteobacteria,2VHFR@28216|Betaproteobacteria,4AAGK@80864|Comamonadaceae 28216|Betaproteobacteria C PFAM cytochrome bd ubiquinol oxidase subunit I cydA - 1.10.3.14 ko:K00425 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00153 R11325 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.4.3 - - Cyt_bd_oxida_I k59_1048262_1 115417.EPrPW00000026193 1.26e-21 94.7 COG1028@1|root,KOG1201@2759|Eukaryota,1MENB@121069|Pythiales 121069|Pythiales Q Retinol dehydrogenase. Source PGD - - - - - - - - - - - - adh_short k59_88396_2 439235.Dalk_1172 6.07e-49 159.0 COG1917@1|root,COG1917@2|Bacteria,1RDGQ@1224|Proteobacteria,42U6Z@68525|delta/epsilon subdivisions,2WQZN@28221|Deltaproteobacteria,2MNDS@213118|Desulfobacterales 28221|Deltaproteobacteria H Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant ectC - 4.2.1.108 ko:K06720 ko00260,ko01100,ko01120,map00260,map01100,map01120 M00033 R06979 RC01729 ko00000,ko00001,ko00002,ko01000 - - - Ectoine_synth k59_1612408_1 331869.BAL199_03579 3.76e-24 100.0 COG2084@1|root,COG2084@2|Bacteria,1NS71@1224|Proteobacteria,2U0T6@28211|Alphaproteobacteria 28211|Alphaproteobacteria I 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases - - 1.1.1.31 ko:K00020 ko00280,ko01100,map00280,map01100 - R05066 RC00099 ko00000,ko00001,ko01000 - - - NAD_binding_11,NAD_binding_2 k59_314044_1 857087.Metme_2051 0.000427 48.9 COG0785@1|root,COG3209@1|root,COG0785@2|Bacteria,COG3209@2|Bacteria 2|Bacteria M self proteolysis mauF - 2.7.11.1 ko:K03466,ko:K06196,ko:K12132 - - - - ko00000,ko01000,ko01001,ko02000,ko03036 3.A.12,5.A.1.2 - - AAA_16,Trans_reg_C k59_708686_1 1121939.L861_19650 2.38e-79 255.0 COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,1RME8@1236|Gammaproteobacteria,1XIG3@135619|Oceanospirillales 135619|Oceanospirillales O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins - - - ko:K03798 - M00742 - - ko00000,ko00002,ko01000,ko01002,ko03110 - - - AAA,FtsH_ext,Peptidase_M41 k59_879126_1 42565.FP66_12330 2.04e-40 150.0 COG0530@1|root,COG0530@2|Bacteria,1MU3R@1224|Proteobacteria,1RMRD@1236|Gammaproteobacteria,1XN20@135619|Oceanospirillales 135619|Oceanospirillales P Sodium/calcium exchanger protein - - - ko:K07301 - - - - ko00000,ko02000 2.A.19.5 - - Na_Ca_ex k59_1667069_1 1122137.AQXF01000002_gene386 1.05e-47 164.0 COG2234@1|root,COG2234@2|Bacteria,1PB6Y@1224|Proteobacteria 1224|Proteobacteria S Peptidase family M28 - - - - - - - - - - - - Peptidase_M28 k59_1667069_2 1122137.AQXF01000002_gene387 3.49e-109 326.0 COG1206@1|root,COG1206@2|Bacteria,1MWNQ@1224|Proteobacteria,2TR6M@28211|Alphaproteobacteria 28211|Alphaproteobacteria J Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs trmFO GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901363 2.1.1.74 ko:K04094 - - - - ko00000,ko01000,ko03016,ko03036 - - - GIDA k59_1270379_1 199310.c5011 5.42e-218 622.0 COG2937@1|root,COG2937@2|Bacteria,1MWZ6@1224|Proteobacteria,1RM7K@1236|Gammaproteobacteria,3XNFZ@561|Escherichia 1236|Gammaproteobacteria I Belongs to the GPAT DAPAT family plsB GO:0003674,GO:0003824,GO:0004366,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006082,GO:0006629,GO:0006631,GO:0006644,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008374,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016020,GO:0016021,GO:0016740,GO:0016746,GO:0016747,GO:0019637,GO:0019752,GO:0031224,GO:0031226,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0071704,GO:0071944,GO:0090407,GO:1901576 2.3.1.15 ko:K00631 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R00851,R09380 RC00004,RC00039,RC00041 ko00000,ko00001,ko00002,ko01000,ko01004 - - iECs_1301.ECs5024,iG2583_1286.G2583_4866 Acyltransferase k59_595497_1 1380394.JADL01000013_gene682 1.42e-22 94.4 COG2175@1|root,COG2175@2|Bacteria,1R5TE@1224|Proteobacteria,2U2FJ@28211|Alphaproteobacteria 28211|Alphaproteobacteria Q Taurine catabolism dioxygenase TauD, TfdA family - - - ko:K06912 ko00361,ko01120,ko01220,map00361,map01120,map01220 - R05419,R05493 RC01371,RC01372 ko00000,ko00001,ko01000 - - - TauD k59_1725050_2 1229909.NSED_06265 5.11e-98 286.0 COG0440@1|root,arCOG04445@2157|Archaea,41SNS@651137|Thaumarchaeota 651137|Thaumarchaeota E acetolactate synthase, small - - 2.2.1.6 ko:K01653 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - ACT,ACT_5,ALS_ss_C k59_761667_1 555793.WSK_2508 7.25e-156 449.0 COG0260@1|root,COG0260@2|Bacteria,1MUIN@1224|Proteobacteria,2TSI6@28211|Alphaproteobacteria,2JZV7@204457|Sphingomonadales 204457|Sphingomonadales E Belongs to the peptidase M17 family - - 3.4.11.1 ko:K01255 ko00480,ko01100,map00480,map01100 - R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 - - - Peptidase_M17 k59_314071_1 1229909.NSED_07540 3.52e-45 156.0 COG0731@1|root,arCOG00953@2157|Archaea 2157|Archaea C Radical SAM domain protein rlmN - 2.1.1.192 ko:K06941 - - - - ko00000,ko01000,ko03009 - - - Fer4_14,Radical_SAM k59_314071_2 1229909.NSED_03375 3.62e-42 151.0 COG0008@1|root,arCOG00402@2157|Archaea,41SFI@651137|Thaumarchaeota 651137|Thaumarchaeota J Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) proS - 6.1.1.15 ko:K01881 ko00970,map00970 M00359,M00360 R03661 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,ProRS-C_1,tRNA-synt_2b k59_1500532_1 1122137.AQXF01000004_gene1445 7.55e-125 362.0 COG0842@1|root,COG0842@2|Bacteria,1MUH1@1224|Proteobacteria,2TQSY@28211|Alphaproteobacteria 28211|Alphaproteobacteria V transport, permease protein yadH - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane k59_595509_1 192875.XP_004349525.1 1.77e-35 133.0 KOG2947@1|root,KOG2947@2759|Eukaryota,38FDS@33154|Opisthokonta 33154|Opisthokonta G ketohexokinase activity KHK GO:0003674,GO:0003824,GO:0004396,GO:0004454,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006000,GO:0006001,GO:0006081,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006109,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008865,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009719,GO:0009725,GO:0009743,GO:0009744,GO:0009746,GO:0009749,GO:0009750,GO:0009987,GO:0010033,GO:0010035,GO:0010038,GO:0010043,GO:0010243,GO:0010675,GO:0010906,GO:0016052,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017144,GO:0018130,GO:0019200,GO:0019222,GO:0019318,GO:0019320,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019682,GO:0019693,GO:0019752,GO:0031323,GO:0032787,GO:0032868,GO:0032881,GO:0034284,GO:0034285,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042221,GO:0042866,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043434,GO:0043436,GO:0043467,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044262,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046365,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046835,GO:0046939,GO:0050789,GO:0050794,GO:0050896,GO:0051186,GO:0051188,GO:0055086,GO:0060255,GO:0061624,GO:0061625,GO:0062012,GO:0065007,GO:0070873,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0080090,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1901652,GO:1901698,GO:1901700 2.7.1.3 ko:K00846 ko00051,ko01100,ko01120,map00051,map01100,map01120 - R00866,R03819 RC00002,RC00017,RC00608 ko00000,ko00001,ko01000,ko04147 - - - PfkB k59_1387334_1 365528.KB891241_gene6084 2.2e-64 214.0 COG0154@1|root,COG0154@2|Bacteria,2GJK5@201174|Actinobacteria,4ES8T@85013|Frankiales 201174|Actinobacteria J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) gatA GO:0008150,GO:0040007 6.3.5.6,6.3.5.7 ko:K02433 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - Amidase k59_1387334_2 1167006.UWK_01078 2.51e-19 82.4 COG0721@1|root,COG0721@2|Bacteria,1QE6H@1224|Proteobacteria,42VPR@68525|delta/epsilon subdivisions,2WRP0@28221|Deltaproteobacteria,2MM1S@213118|Desulfobacterales 28221|Deltaproteobacteria J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) gatC - 6.3.5.6,6.3.5.7 ko:K02435 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - iAF987.Gmet_0076 Glu-tRNAGln k59_708704_1 1300345.LF41_2610 3.1e-53 193.0 COG2909@1|root,COG3629@1|root,COG2909@2|Bacteria,COG3629@2|Bacteria,1MVZZ@1224|Proteobacteria,1RN29@1236|Gammaproteobacteria,1X3EM@135614|Xanthomonadales 135614|Xanthomonadales K transcriptional regulator acoK - - ko:K03556 - - - - ko00000,ko03000 - - - AAA_16,AAA_25,GerE,TPR_12 k59_708704_2 351746.Pput_2238 0.000312 42.7 COG0405@1|root,COG0405@2|Bacteria,1MUV6@1224|Proteobacteria,1RMIT@1236|Gammaproteobacteria,1YV1V@136845|Pseudomonas putida group 1236|Gammaproteobacteria M gamma-glutamyltransferase ggt - 2.3.2.2,3.4.19.13 ko:K00681 ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100 - R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935 RC00064,RC00090,RC00096 ko00000,ko00001,ko01000,ko01002 - - - G_glu_transpept k59_1612443_1 1121937.AUHJ01000012_gene2800 7.37e-99 298.0 COG0137@1|root,COG0137@2|Bacteria,1MV0Y@1224|Proteobacteria,1RMEC@1236|Gammaproteobacteria,464YE@72275|Alteromonadaceae 1236|Gammaproteobacteria E Belongs to the argininosuccinate synthase family. Type 1 subfamily argG GO:0000050,GO:0000053,GO:0003674,GO:0003824,GO:0004055,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006575,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0019627,GO:0019752,GO:0034641,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:0072350,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 6.3.4.5 ko:K01940 ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418 M00029,M00844,M00845 R01954 RC00380,RC00629 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Arginosuc_synth k59_31294_1 243159.AFE_2600 1.92e-21 85.5 COG0425@1|root,COG0425@2|Bacteria,1NDVB@1224|Proteobacteria,1T176@1236|Gammaproteobacteria,2ND8U@225057|Acidithiobacillales 225057|Acidithiobacillales O Belongs to the sulfur carrier protein TusA family - - - - - - - - - - - - TusA k59_31294_2 1123393.KB891316_gene1812 6.38e-38 131.0 COG2210@1|root,COG2210@2|Bacteria,1NXM5@1224|Proteobacteria 1224|Proteobacteria S DsrE/DsrF/DrsH-like family - - - - - - - - - - - - DrsE_2 k59_818836_1 1125863.JAFN01000001_gene2128 2.76e-89 267.0 COG1348@1|root,COG1348@2|Bacteria,1MVTE@1224|Proteobacteria,42NE5@68525|delta/epsilon subdivisions,2WJ14@28221|Deltaproteobacteria 28221|Deltaproteobacteria P The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components the iron protein and the molybdenum-iron protein nifH - 1.18.6.1 ko:K02588 ko00625,ko00910,ko01100,ko01120,map00625,map00910,map01100,map01120 M00175 R05185,R05496 RC00002,RC01395,RC02891 ko00000,ko00001,ko00002,ko01000 - - - Fer4_NifH k59_534719_1 1469557.JSWF01000026_gene3432 3.69e-72 231.0 COG1055@1|root,COG1055@2|Bacteria,4NGP4@976|Bacteroidetes,1HYB2@117743|Flavobacteriia 976|Bacteroidetes P Na H antiporter NhaD and related arsenite nhaD - - - - - - - - - - - CitMHS k59_256142_1 1127673.GLIP_1292 5.78e-139 417.0 COG4773@1|root,COG4773@2|Bacteria,1MW5E@1224|Proteobacteria,1RMBD@1236|Gammaproteobacteria,4657T@72275|Alteromonadaceae 1236|Gammaproteobacteria P TonB dependent receptor - - - ko:K16088 - - - - ko00000,ko02000 1.B.14.1.10,1.B.14.1.3,1.B.14.1.8 - - Plug,TonB_dep_Rec k59_761682_1 1122137.AQXF01000007_gene3622 2.35e-82 264.0 COG0376@1|root,COG0376@2|Bacteria,1MUBF@1224|Proteobacteria,2TQJ7@28211|Alphaproteobacteria 28211|Alphaproteobacteria P Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity katG - 1.11.1.21 ko:K03782 ko00360,ko00380,ko00940,ko00983,ko01100,ko01110,map00360,map00380,map00940,map00983,map01100,map01110 - R00602,R00698,R02596,R02670,R03919,R04007,R07443,R11906 RC00034,RC00213,RC00767,RC02141 ko00000,ko00001,ko01000 - - - peroxidase k59_818839_2 1387312.BAUS01000007_gene2362 4.63e-21 92.0 COG0482@1|root,COG0482@2|Bacteria,1MUT1@1224|Proteobacteria,2VJRR@28216|Betaproteobacteria,2KM9V@206350|Nitrosomonadales 206350|Nitrosomonadales J Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 mnmA - 2.8.1.13 ko:K00566 ko04122,map04122 - R08700 RC02313,RC02315 ko00000,ko00001,ko01000,ko03016 - - - tRNA_Me_trans k59_1500558_1 1469557.JSWF01000034_gene833 3.53e-75 229.0 28Y1Y@1|root,2ZJXI@2|Bacteria,4NMQK@976|Bacteroidetes,1I1WY@117743|Flavobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_708724_1 402881.Plav_1026 7.23e-87 267.0 COG0183@1|root,COG0183@2|Bacteria,1MUZV@1224|Proteobacteria,2TRHF@28211|Alphaproteobacteria,1JPBG@119043|Rhodobiaceae 28211|Alphaproteobacteria I acetyl-coa acetyltransferase - - 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N k59_649169_2 742738.HMPREF9460_00797 0.000105 44.7 COG1595@1|root,COG1595@2|Bacteria,1V9UJ@1239|Firmicutes,24M76@186801|Clostridia,269EX@186813|unclassified Clostridiales 186801|Clostridia K Sigma-70, region 4 - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 k59_1567145_1 640081.Dsui_1393 1.92e-97 300.0 COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,2VHQ1@28216|Betaproteobacteria,2KUQA@206389|Rhodocyclales 206389|Rhodocyclales NU Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB - - - ko:K02454,ko:K02652 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02035,ko02044 3.A.15,3.A.15.2 - - T2SSE,T2SSE_N k59_323574_1 1484460.JSWG01000009_gene87 3.66e-79 250.0 COG2931@1|root,COG5434@1|root,COG2931@2|Bacteria,COG5434@2|Bacteria,4NFZJ@976|Bacteroidetes,1HZP4@117743|Flavobacteriia 976|Bacteroidetes M Large extracellular alpha-helical protein - - - - - - - - - - - - PSCyt1 k59_96116_2 348058.B9UDG7_9CAUD 1.97e-07 52.8 4QDBZ@10239|Viruses,4QVH1@35237|dsDNA viruses no RNA stage,4QQJ0@28883|Caudovirales,4QNCU@10744|Podoviridae 10744|Podoviridae - - - - - - - - - - - - - - - k59_718291_2 1123277.KB893195_gene5662 6.59e-47 169.0 COG1529@1|root,COG1529@2|Bacteria,4NFFU@976|Bacteroidetes,47N2K@768503|Cytophagia 976|Bacteroidetes C Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain - - 1.3.99.16 ko:K07303 - - - - ko00000,ko01000 - - - Ald_Xan_dh_C,Ald_Xan_dh_C2 k59_1334597_1 525904.Tter_0568 1.02e-52 183.0 COG0247@1|root,COG0247@2|Bacteria,2NNXS@2323|unclassified Bacteria 2|Bacteria C Cysteine-rich domain - - - ko:K11473 ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130 - R00475 RC00042 ko00000,ko00001 - - - CCG,Fer4_17,Fer4_7,Fer4_8 k59_1334597_2 2074.JNYD01000013_gene6826 1.45e-08 59.7 COG0277@1|root,COG0277@2|Bacteria,2H3K3@201174|Actinobacteria,4E18A@85010|Pseudonocardiales 201174|Actinobacteria C overlaps another CDS with the same product name glcE - - ko:K11472 ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130 - R00475 RC00042 ko00000,ko00001 - - - FAD-oxidase_C,FAD_binding_4 k59_1396585_2 436308.Nmar_1504 6.24e-30 108.0 arCOG08674@1|root,arCOG08674@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_1448036_1 748658.KB907312_gene1713 4.65e-21 89.7 2EK1K@1|root,33DS2@2|Bacteria,1NI6I@1224|Proteobacteria,1SH8F@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_1448036_2 472759.Nhal_2223 3.29e-63 206.0 COG0591@1|root,COG0591@2|Bacteria,1N8H2@1224|Proteobacteria,1RR54@1236|Gammaproteobacteria,1X0GD@135613|Chromatiales 135613|Chromatiales E Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family - - - - - - - - - - - - SSF k59_1448039_1 1206726.BAFV01000071_gene4963 2.44e-19 90.1 COG2124@1|root,COG2124@2|Bacteria,2GKCG@201174|Actinobacteria,4FWXA@85025|Nocardiaceae 201174|Actinobacteria Q Cytochrome P450 - - 1.14.15.14 ko:K20497 - - - - ko00000,ko00199,ko01000 - - - p450 k59_1277825_1 1288494.EBAPG3_25110 1.43e-29 110.0 COG0517@1|root,COG0517@2|Bacteria,1QTXQ@1224|Proteobacteria,2VWDB@28216|Betaproteobacteria,3734T@32003|Nitrosomonadales 28216|Betaproteobacteria S Domain in cystathionine beta-synthase and other proteins. - - - - - - - - - - - - CBS k59_1277825_2 1123393.KB891326_gene80 3.76e-28 107.0 COG1544@1|root,COG1544@2|Bacteria,1RJ55@1224|Proteobacteria,2VR5Q@28216|Betaproteobacteria,1KSAT@119069|Hydrogenophilales 119069|Hydrogenophilales J 'Cold-shock' DNA-binding domain - - - - - - - - - - - - CSD,Ribosomal_S30AE k59_1334616_1 395493.BegalDRAFT_3535 1.27e-85 261.0 COG0136@1|root,COG0136@2|Bacteria,1MUHG@1224|Proteobacteria,1RNB6@1236|Gammaproteobacteria,4605M@72273|Thiotrichales 72273|Thiotrichales E Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate asd - 1.2.1.11 ko:K00133 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00017,M00018,M00033,M00525,M00526,M00527 R02291 RC00684 ko00000,ko00001,ko00002,ko01000 - - - Semialdhyde_dh,Semialdhyde_dhC k59_605217_1 436308.Nmar_0977 3.83e-107 322.0 COG0702@1|root,arCOG03015@2157|Archaea 2157|Archaea GM NAD-dependent epimerase dehydratase - - 4.2.1.46 ko:K01710 ko00521,ko00523,ko00525,ko01055,ko01130,map00521,map00523,map00525,map01055,map01130 M00793 R06513 RC00402 ko00000,ko00001,ko00002,ko01000 - - - NAD_binding_10 k59_888527_1 1472716.KBK24_0102230 3.42e-41 141.0 COG2335@1|root,COG2335@2|Bacteria,1RD06@1224|Proteobacteria,2VSZ8@28216|Betaproteobacteria,1K6VJ@119060|Burkholderiaceae 28216|Betaproteobacteria M Four repeated domains in the Fasciclin I family of proteins, present in many other contexts. - - - - - - - - - - - - Fasciclin k59_1620142_1 314231.FP2506_13344 5.58e-15 72.8 COG1024@1|root,COG1024@2|Bacteria,1MXBB@1224|Proteobacteria,2TSPM@28211|Alphaproteobacteria 28211|Alphaproteobacteria I Enoyl-CoA hydratase MA20_43195 - - - - - - - - - - - ECH_1 k59_1620142_2 1288298.rosmuc_00338 5.37e-57 189.0 COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,2TQW5@28211|Alphaproteobacteria,46QKT@74030|Roseovarius 28211|Alphaproteobacteria G COG1593 TRAP-type C4-dicarboxylate transport system, large permease component - - - - - - - - - - - - DctM k59_1674393_1 1000565.METUNv1_01510 1.47e-75 240.0 COG0446@1|root,COG0446@2|Bacteria,1NR3M@1224|Proteobacteria,2VKIS@28216|Betaproteobacteria,2KVRE@206389|Rhodocyclales 206389|Rhodocyclales S FAD-dependent pyridine - - - - - - - - - - - - Pyr_redox_2 k59_994856_1 1229909.NSED_06495 9.62e-98 286.0 COG2406@1|root,arCOG01093@2157|Archaea,41S6X@651137|Thaumarchaeota 651137|Thaumarchaeota S Ferritin-like domain - - - - - - - - - - - - Ferritin k59_994856_2 1229909.NSED_06500 6.25e-20 82.4 arCOG08645@1|root,arCOG08645@2157|Archaea,41STW@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1334633_1 1380393.JHVP01000001_gene2577 4.39e-52 189.0 COG0507@1|root,COG1112@1|root,COG2251@1|root,COG0507@2|Bacteria,COG1112@2|Bacteria,COG2251@2|Bacteria,2GMX8@201174|Actinobacteria 201174|Actinobacteria L nuclease - - - - - - - - - - - - AAA_11,AAA_12,AAA_30,PDDEXK_1,RNase_H_2 k59_40458_1 246199.CUS_4271 1.98e-44 148.0 COG2755@1|root,COG2755@2|Bacteria,1UFZN@1239|Firmicutes,24V88@186801|Clostridia 186801|Clostridia E GDSL-like Lipase/Acylhydrolase - - 3.1.1.5 ko:K10804 ko01040,map01040 - - - ko00000,ko00001,ko01000,ko01004 - - - Lipase_GDSL_2 k59_40458_2 316407.85674632 1.04e-91 273.0 COG0300@1|root,COG0300@2|Bacteria,1RGKZ@1224|Proteobacteria,1T1HV@1236|Gammaproteobacteria,3XPHF@561|Escherichia 1236|Gammaproteobacteria S alcohol dehydrogenase (NADP+) activity ybbO GO:0003674,GO:0003824,GO:0004033,GO:0008106,GO:0008150,GO:0008152,GO:0016491,GO:0016614,GO:0016616,GO:0055114 - - - - - - - - - - adh_short k59_380020_1 1123487.KB892865_gene1380 7.59e-63 212.0 COG3170@1|root,COG3170@2|Bacteria,1PMRK@1224|Proteobacteria,2W7ZG@28216|Betaproteobacteria,2KZB6@206389|Rhodocyclales 206389|Rhodocyclales NU Tfp pilus assembly protein FimV - - - - - - - - - - - - - k59_1674408_1 506534.Rhein_0400 9.08e-76 252.0 COG4225@1|root,COG4225@2|Bacteria,1MU2J@1224|Proteobacteria,1RR65@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Glycosyl Hydrolase Family 88 - - - - - - - - - - - - DUF4861,Glyco_hydro_88 k59_96177_1 1121920.AUAU01000004_gene764 7.55e-151 441.0 COG0415@1|root,COG0415@2|Bacteria 2|Bacteria L Belongs to the DNA photolyase family phrB GO:0000003,GO:0000166,GO:0000719,GO:0001101,GO:0002252,GO:0002376,GO:0003006,GO:0003674,GO:0003824,GO:0003904,GO:0003913,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005773,GO:0006139,GO:0006259,GO:0006281,GO:0006290,GO:0006325,GO:0006338,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006873,GO:0006874,GO:0006875,GO:0006950,GO:0006952,GO:0006974,GO:0006996,GO:0007154,GO:0007165,GO:0007275,GO:0007623,GO:0008144,GO:0008150,GO:0008152,GO:0009117,GO:0009314,GO:0009414,GO:0009415,GO:0009416,GO:0009605,GO:0009606,GO:0009607,GO:0009615,GO:0009628,GO:0009637,GO:0009638,GO:0009642,GO:0009645,GO:0009646,GO:0009648,GO:0009719,GO:0009725,GO:0009785,GO:0009791,GO:0009881,GO:0009882,GO:0009888,GO:0009893,GO:0009909,GO:0009911,GO:0009987,GO:0010033,GO:0010035,GO:0010073,GO:0010075,GO:0010118,GO:0010228,GO:0010244,GO:0010617,GO:0014070,GO:0016043,GO:0016604,GO:0016829,GO:0016830,GO:0017076,GO:0019222,GO:0019637,GO:0019725,GO:0022414,GO:0022603,GO:0023052,GO:0030003,GO:0030522,GO:0030554,GO:0031323,GO:0031325,GO:0031974,GO:0031981,GO:0032501,GO:0032502,GO:0032553,GO:0032555,GO:0032559,GO:0033554,GO:0033993,GO:0034641,GO:0035639,GO:0036094,GO:0038023,GO:0040008,GO:0042221,GO:0042592,GO:0042726,GO:0042752,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0043207,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0044237,GO:0044238,GO:0044260,GO:0044281,GO:0044422,GO:0044424,GO:0044428,GO:0044444,GO:0044446,GO:0044451,GO:0044464,GO:0046483,GO:0048037,GO:0048507,GO:0048509,GO:0048511,GO:0048518,GO:0048522,GO:0048571,GO:0048573,GO:0048574,GO:0048580,GO:0048582,GO:0048583,GO:0048608,GO:0048638,GO:0048731,GO:0048831,GO:0048856,GO:0048878,GO:0050660,GO:0050662,GO:0050789,GO:0050793,GO:0050794,GO:0050801,GO:0050896,GO:0051094,GO:0051186,GO:0051239,GO:0051240,GO:0051276,GO:0051480,GO:0051607,GO:0051704,GO:0051707,GO:0051716,GO:0055065,GO:0055074,GO:0055080,GO:0055082,GO:0055086,GO:0060089,GO:0061458,GO:0065007,GO:0065008,GO:0070013,GO:0071214,GO:0071478,GO:0071482,GO:0071483,GO:0071704,GO:0071840,GO:0071949,GO:0072387,GO:0072503,GO:0072507,GO:0090304,GO:0097159,GO:0097367,GO:0098542,GO:0098771,GO:0104004,GO:0140097,GO:1900618,GO:1901265,GO:1901360,GO:1901363,GO:1901371,GO:1901564,GO:1901700,GO:1902347,GO:1905421,GO:2000024,GO:2000026,GO:2000028,GO:2000241,GO:2000243,GO:2000377,GO:2000379 4.1.99.3 ko:K01669 - - - - ko00000,ko01000,ko03400 - - - DNA_photolyase,FAD_binding_7 k59_1674410_1 316407.1742575 1.65e-30 108.0 2AV3H@1|root,31KTH@2|Bacteria,1QIP0@1224|Proteobacteria,1TGIC@1236|Gammaproteobacteria,3XR4Z@561|Escherichia 1236|Gammaproteobacteria - - ydfC - - - - - - - - - - - - k59_828194_1 1380387.JADM01000008_gene991 2.78e-23 103.0 COG0741@1|root,COG0741@2|Bacteria,1MV3F@1224|Proteobacteria,1RMS8@1236|Gammaproteobacteria,1XIND@135619|Oceanospirillales 135619|Oceanospirillales M COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains) slt - - ko:K08309 - - - - ko00000,ko01000,ko01011 - GH23 - SLT,SLT_L k59_1109148_1 1163398.AJJP01000129_gene4038 2.63e-05 51.6 COG4206@1|root,COG4206@2|Bacteria,1QTTF@1224|Proteobacteria,1T1GM@1236|Gammaproteobacteria 1236|Gammaproteobacteria H receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_1277872_1 360094.PXO_02388 1.02e-28 111.0 COG0352@1|root,COG0352@2|Bacteria,1RDSU@1224|Proteobacteria,1S6QS@1236|Gammaproteobacteria,1X6BT@135614|Xanthomonadales 135614|Xanthomonadales H Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) thiE GO:0003674,GO:0003824,GO:0004789,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.3 ko:K00788 ko00730,ko01100,map00730,map01100 M00127 R03223,R10712 RC00224,RC03255,RC03397 ko00000,ko00001,ko00002,ko01000 - - - TMP-TENI k59_542099_1 933262.AXAM01000056_gene3188 3.08e-58 197.0 COG1058@1|root,COG1546@1|root,COG1058@2|Bacteria,COG1546@2|Bacteria,1RH2Y@1224|Proteobacteria,42MQ4@68525|delta/epsilon subdivisions,2WMDT@28221|Deltaproteobacteria,2MHNR@213118|Desulfobacterales 28221|Deltaproteobacteria S TIGRFAM competence damage-inducible protein CinA cinA GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006139,GO:0006259,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363 3.5.1.42 ko:K03742,ko:K03743 ko00760,map00760 - R02322 RC00100 ko00000,ko00001,ko01000 - - - CinA,MoCF_biosynth k59_1732719_1 1123267.JONN01000002_gene313 1.55e-70 234.0 COG0643@1|root,COG0643@2|Bacteria,1MUAG@1224|Proteobacteria,2TSN2@28211|Alphaproteobacteria,2K0Z1@204457|Sphingomonadales 204457|Sphingomonadales NT chemotaxis protein cheA - 2.7.13.3 ko:K03407 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 - - - CheW,H-kinase_dim,HATPase_c,Hpt k59_542106_1 158500.BV97_04782 1.02e-105 311.0 COG0354@1|root,COG0354@2|Bacteria,1N852@1224|Proteobacteria,2TR8J@28211|Alphaproteobacteria,2K18B@204457|Sphingomonadales 204457|Sphingomonadales S Aminomethyltransferase - - - ko:K06980 - - - - ko00000,ko03016 - - - GCV_T k59_1277888_2 1122212.AULO01000013_gene2005 2.77e-05 46.2 COG0796@1|root,COG0796@2|Bacteria,1NAI2@1224|Proteobacteria,1RPU9@1236|Gammaproteobacteria,1XJHU@135619|Oceanospirillales 135619|Oceanospirillales M Provides the (R)-glutamate required for cell wall biosynthesis murI - 5.1.1.3 ko:K01776 ko00471,ko01100,map00471,map01100 - R00260 RC00302 ko00000,ko00001,ko01000,ko01011 - - - Asp_Glu_race k59_208015_1 1123393.KB891317_gene2304 9.23e-47 158.0 COG1043@1|root,COG1043@2|Bacteria,1MUHQ@1224|Proteobacteria,2VHDG@28216|Betaproteobacteria,1KRBA@119069|Hydrogenophilales 119069|Hydrogenophilales M Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell lpxA - 2.3.1.129 ko:K00677 ko00540,ko01100,ko01503,map00540,map01100,map01503 M00060 R04567 RC00039,RC00055 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Acetyltransf_11,Hexapep k59_1277895_1 394221.Mmar10_1402 6.83e-40 150.0 COG2861@1|root,COG2861@2|Bacteria,1N3JP@1224|Proteobacteria,2TUFD@28211|Alphaproteobacteria,43ZVG@69657|Hyphomonadaceae 28211|Alphaproteobacteria S Divergent polysaccharide deacetylase - - - ko:K09798 - - - - ko00000 - - - Polysacc_deac_2 k59_1509776_1 502025.Hoch_5890 2.67e-30 117.0 COG0389@1|root,COG0389@2|Bacteria,1MUUH@1224|Proteobacteria,42NGG@68525|delta/epsilon subdivisions,2WIVT@28221|Deltaproteobacteria,2YU4K@29|Myxococcales 28221|Deltaproteobacteria L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII dinB - 2.7.7.7 ko:K02346 - - - - ko00000,ko01000,ko03400 - - - IMS,IMS_C,IMS_HHH k59_1509776_2 553385.JEMF01000021_gene3127 5.88e-84 261.0 COG0142@1|root,COG0142@2|Bacteria,1MWNG@1224|Proteobacteria,1RMKY@1236|Gammaproteobacteria,1XHEV@135619|Oceanospirillales 135619|Oceanospirillales H Belongs to the FPP GGPP synthase family ispA - 2.5.1.1,2.5.1.10,2.5.1.29 ko:K00795,ko:K13789 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00364,M00366 R01658,R02003,R02061 RC00279 ko00000,ko00001,ko00002,ko01000,ko01006 - - - polyprenyl_synt k59_1334686_1 395963.Bind_1031 2.7e-08 55.5 COG0615@1|root,COG2870@1|root,COG0615@2|Bacteria,COG2870@2|Bacteria,1MV3Z@1224|Proteobacteria,2TU12@28211|Alphaproteobacteria,3NAVZ@45404|Beijerinckiaceae 28211|Alphaproteobacteria H Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose hldE - 2.7.1.167,2.7.7.70 ko:K03272 ko00540,ko01100,map00540,map01100 M00064 R05644,R05646 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000,ko01005 - - - CTP_transf_like,PfkB k59_1334686_2 1144275.COCOR_02689 1.94e-20 93.6 COG1561@1|root,COG1561@2|Bacteria,1MWRA@1224|Proteobacteria,42RFR@68525|delta/epsilon subdivisions,2WJYK@28221|Deltaproteobacteria,2YVIN@29|Myxococcales 28221|Deltaproteobacteria S Domain of unknown function (DUF1732) yicC - - - - - - - - - - - DUF1732,YicC_N k59_769412_3 883077.HMPREF9241_01712 2.43e-23 103.0 COG0791@1|root,COG0791@2|Bacteria,2I78U@201174|Actinobacteria,4D8B5@85005|Actinomycetales 201174|Actinobacteria M CHAP domain - - - - - - - - - - - - CHAP k59_939639_2 247634.GPB2148_3664 3.52e-57 181.0 COG3339@1|root,COG3339@2|Bacteria,1MZR5@1224|Proteobacteria,1S912@1236|Gammaproteobacteria,1J6X5@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Protein of unknown function (DUF1232) - - - - - - - - - - - - DUF1232 k59_1732729_1 671143.DAMO_1619 2.96e-82 263.0 COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,2NPPN@2323|unclassified Bacteria 2|Bacteria C Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg korA GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0030312,GO:0044464,GO:0050896,GO:0055114,GO:0071944 1.2.7.11,1.2.7.3 ko:K00174 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - PFOR_II,POR,POR_N k59_1732729_2 1201288.M900_1674 2.92e-22 95.5 COG0454@1|root,COG0456@2|Bacteria,1N9KA@1224|Proteobacteria,431PF@68525|delta/epsilon subdivisions,2MTBE@213481|Bdellovibrionales,2WW76@28221|Deltaproteobacteria 213481|Bdellovibrionales K Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_1,Acetyltransf_10 k59_1277899_1 1174684.EBMC1_02275 6.17e-102 321.0 COG4774@1|root,COG4774@2|Bacteria,1NMCN@1224|Proteobacteria,2U0J1@28211|Alphaproteobacteria,2K2U9@204457|Sphingomonadales 204457|Sphingomonadales P TonB dependent receptor - - - - - - - - - - - - Plug,TonB_dep_Rec k59_265342_1 1123377.AUIV01000034_gene668 6.96e-71 238.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1X3JU@135614|Xanthomonadales 135614|Xanthomonadales V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_1224566_1 483219.LILAB_13395 7.55e-43 148.0 COG1225@1|root,COG1225@2|Bacteria,1RD4R@1224|Proteobacteria,42RHG@68525|delta/epsilon subdivisions,2WQ59@28221|Deltaproteobacteria,2YV5F@29|Myxococcales 28221|Deltaproteobacteria O Redoxin prx-4 - 1.11.1.15 ko:K03564 - - - - ko00000,ko01000 - - - AhpC-TSA k59_542138_1 767434.Fraau_0171 1.96e-51 173.0 COG0500@1|root,COG2226@2|Bacteria,1PA5F@1224|Proteobacteria,1RY7A@1236|Gammaproteobacteria,1X53I@135614|Xanthomonadales 135614|Xanthomonadales H Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway bioC - 2.1.1.197 ko:K02169 ko00780,ko01100,map00780,map01100 M00572 R09543 RC00003,RC00460 ko00000,ko00001,ko00002,ko01000 - - - Methyltransf_11 k59_1396683_1 1492922.GY26_08375 2.5e-21 87.4 COG3549@1|root,COG3549@2|Bacteria,1MZKX@1224|Proteobacteria,1TF9J@1236|Gammaproteobacteria,1JBQP@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S RelE-like toxin of type II toxin-antitoxin system HigB - - - - - - - - - - - - HigB-like_toxin k59_1674473_1 1122137.AQXF01000003_gene2466 4.48e-141 411.0 COG0119@1|root,COG0119@2|Bacteria,1MUNQ@1224|Proteobacteria,2TSCJ@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) leuA - 2.3.3.13 ko:K01649 ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230 M00432 R01213 RC00004,RC00470,RC02754 br01601,ko00000,ko00001,ko00002,ko01000 - - - HMGL-like,LeuA_dimer k59_994917_1 637911.AM305_07748 8.05e-33 119.0 COG0629@1|root,COG0629@2|Bacteria,1RCWT@1224|Proteobacteria,1S3WP@1236|Gammaproteobacteria,1YA3M@135625|Pasteurellales 135625|Pasteurellales L Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism - - - ko:K03111 ko03030,ko03430,ko03440,map03030,map03430,map03440 - - - ko00000,ko00001,ko03029,ko03032,ko03400 - - - SSB k59_1168663_1 765910.MARPU_03685 4.39e-205 609.0 COG0085@1|root,COG0085@2|Bacteria,1MUC4@1224|Proteobacteria,1RMK0@1236|Gammaproteobacteria,1WX4P@135613|Chromatiales 135613|Chromatiales K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoB - 2.7.7.6 ko:K03043 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7 k59_150553_1 95619.PM1_0222195 1.52e-81 265.0 COG2609@1|root,COG2609@2|Bacteria,1MV21@1224|Proteobacteria,1SJVI@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) - - 1.2.4.1 ko:K00163 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200 M00307 R00014,R00209,R01699,R03270 RC00004,RC00027,RC00627,RC02742,RC02744,RC02882 br01601,ko00000,ko00001,ko00002,ko01000 - - - Transketolase_N k59_1620241_1 391598.FBBAL38_01285 2.52e-34 134.0 COG0439@1|root,COG0439@2|Bacteria,4NFEQ@976|Bacteroidetes,1IJW9@117743|Flavobacteriia 976|Bacteroidetes I Biotin carboxylase C-terminal domain accC - 6.3.4.14,6.4.1.2,6.4.1.3 ko:K01961,ko:K01965 ko00061,ko00280,ko00620,ko00630,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00280,map00620,map00630,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00373,M00376,M00741 R00742,R01859,R04385 RC00040,RC00097,RC00253,RC00367,RC00609 ko00000,ko00001,ko00002,ko01000 - - - Biotin_carb_C,Biotin_carb_N,CPSase_L_D2 k59_150563_1 857087.Metme_1112 5.73e-106 316.0 COG1117@1|root,COG1117@2|Bacteria,1MU16@1224|Proteobacteria,1RNUF@1236|Gammaproteobacteria,1XDTC@135618|Methylococcales 1236|Gammaproteobacteria P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system - - 3.6.3.27 ko:K02036 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.7 - - ABC_tran k59_1334716_1 1128421.JAGA01000002_gene1459 1.42e-21 97.1 COG2204@1|root,COG2206@1|root,COG2204@2|Bacteria,COG2206@2|Bacteria,2NS55@2323|unclassified Bacteria 2|Bacteria T HD domain - - - ko:K07814 - - - - ko00000,ko02022 - - - DUF3369,GAF_2,GAF_3,GGDEF,HD,HD_5,Response_reg,TPR_12 k59_1334716_2 338969.Rfer_2738 0.000224 42.4 COG2204@1|root,COG2204@2|Bacteria,1QZ6X@1224|Proteobacteria 1224|Proteobacteria T response regulator - - - - - - - - - - - - Response_reg k59_1567297_1 631362.Thi970DRAFT_00706 7.13e-28 116.0 COG5000@1|root,COG5000@2|Bacteria,1MWKZ@1224|Proteobacteria,1RQ8B@1236|Gammaproteobacteria,1WXE6@135613|Chromatiales 135613|Chromatiales T signal transduction histidine kinase - - - - - - - - - - - - HAMP,HATPase_c,HisKA,PAS_4,PAS_8 k59_380094_1 351607.Acel_1015 3.21e-65 215.0 COG0247@1|root,COG0247@2|Bacteria,2I3IR@201174|Actinobacteria,4EUJ2@85013|Frankiales 201174|Actinobacteria C 4Fe-4S dicluster domain - - - - - - - - - - - - Fer4_22 k59_994929_1 1122137.AQXF01000004_gene1427 6.77e-63 206.0 COG4223@1|root,COG4223@2|Bacteria 2|Bacteria DZ transferase activity, transferring acyl groups other than amino-acyl groups - - 4.2.1.75 ko:K01719 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R03165 RC01861 ko00000,ko00001,ko00002,ko01000 - - - FlxA,Mitofilin k59_994929_2 1122137.AQXF01000004_gene1428 2.45e-178 510.0 COG3898@1|root,COG3898@2|Bacteria,1P5RR@1224|Proteobacteria,2TT5Q@28211|Alphaproteobacteria 28211|Alphaproteobacteria S HemY domain protein lapB - - ko:K02498 - - - - ko00000 - - - HemY_N,TPR_19 k59_265374_1 929712.KI912613_gene300 9.4e-67 214.0 COG2378@1|root,COG2378@2|Bacteria,2GIZC@201174|Actinobacteria,4CSA9@84995|Rubrobacteria 84995|Rubrobacteria K PFAM Helix-turn-helix type 11 domain protein - - - - - - - - - - - - HTH_11,WYL k59_265374_2 391625.PPSIR1_30701 1.11e-75 233.0 COG0625@1|root,COG0625@2|Bacteria,1R6XK@1224|Proteobacteria 1224|Proteobacteria O Glutathione S-transferase - - - ko:K11209 - - - - ko00000,ko01000 - - - GST_C,GST_C_2,GST_N k59_265374_3 1382303.JPOM01000001_gene1408 1.92e-27 117.0 COG2211@1|root,COG2211@2|Bacteria,1MVUM@1224|Proteobacteria,2TVI8@28211|Alphaproteobacteria,2KJSU@204458|Caulobacterales 204458|Caulobacterales G MFS/sugar transport protein - - - - - - - - - - - - MFS_2 k59_1168689_1 247633.GP2143_17131 3e-77 245.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,1J4KP@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains glnG GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - ko:K07712 ko02020,map02020 M00497 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_1224624_1 983920.Y88_0267 1.7e-52 179.0 COG4993@1|root,COG4993@2|Bacteria,1MUQX@1224|Proteobacteria,2TS2Q@28211|Alphaproteobacteria,2K18E@204457|Sphingomonadales 204457|Sphingomonadales CG Dehydrogenase - - 1.1.2.8 ko:K00114 ko00010,ko00625,ko01100,ko01110,ko01120,ko01130,map00010,map00625,map01100,map01110,map01120,map01130 - R05062,R05198,R05285 RC00087,RC00088,RC01039 ko00000,ko00001,ko01000 - - - PQQ k59_1224624_2 158500.BV97_02336 1.04e-46 156.0 COG2197@1|root,COG2197@2|Bacteria,1P4TD@1224|Proteobacteria,2U06A@28211|Alphaproteobacteria,2K45U@204457|Sphingomonadales 204457|Sphingomonadales T Regulator - - - - - - - - - - - - GerE,Response_reg k59_994943_1 414684.RC1_1560 1.79e-19 85.1 COG0194@1|root,COG0194@2|Bacteria,1MW92@1224|Proteobacteria,2TSCQ@28211|Alphaproteobacteria,2JPXS@204441|Rhodospirillales 204441|Rhodospirillales F Essential for recycling GMP and indirectly, cGMP gmk - 2.7.4.8 ko:K00942 ko00230,ko01100,map00230,map01100 M00050 R00332,R02090 RC00002 ko00000,ko00001,ko00002,ko01000 - - - Guanylate_kin k59_994943_2 1238182.C882_4570 2.78e-45 155.0 COG1561@1|root,COG1561@2|Bacteria,1MWRA@1224|Proteobacteria,2TS81@28211|Alphaproteobacteria,2JPK7@204441|Rhodospirillales 204441|Rhodospirillales S Domain of unknown function (DUF1732) - - - - - - - - - - - - DUF1732,YicC_N k59_97134_1 1192868.CAIU01000006_gene483 7.14e-16 75.9 COG1309@1|root,COG1309@2|Bacteria,1R59A@1224|Proteobacteria,2U08S@28211|Alphaproteobacteria,43RPT@69277|Phyllobacteriaceae 28211|Alphaproteobacteria K Bacterial regulatory proteins, tetR family - - - - - - - - - - - - TetR_N k59_1621175_1 1177181.T9A_00440 9.9e-22 90.9 COG3255@1|root,COG3255@2|Bacteria,1N01E@1224|Proteobacteria,1SBCB@1236|Gammaproteobacteria 1236|Gammaproteobacteria I sterol carrier protein - - - - - - - - - - - - SCP2 k59_1621175_2 1203550.HMPREF1475_01902 0.000189 49.3 COG3735@1|root,COG3735@2|Bacteria,4NN4U@976|Bacteroidetes,2FNN7@200643|Bacteroidia 976|Bacteroidetes S GumN protein - - - ko:K09973 - - - - ko00000 - - - TraB k59_719573_1 1504672.669786654 5.05e-34 125.0 COG1215@1|root,COG1215@2|Bacteria,1RA75@1224|Proteobacteria,2VQQD@28216|Betaproteobacteria,4ADRH@80864|Comamonadaceae 28216|Betaproteobacteria M Glycosyl transferase family 2 - - - - - - - - - - - - Glycos_transf_2 k59_1344523_2 158500.BV97_01056 1.47e-32 120.0 2D4T1@1|root,32THI@2|Bacteria,1N892@1224|Proteobacteria,2TWF7@28211|Alphaproteobacteria,2KEER@204457|Sphingomonadales 204457|Sphingomonadales S PFAM SapC family protein - - - - - - - - - - - - SapC k59_1004997_1 1415778.JQMM01000001_gene1180 6.94e-124 381.0 COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,1RMS9@1236|Gammaproteobacteria,1J57N@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate uvrA GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009314,GO:0009380,GO:0009381,GO:0009628,GO:0009987,GO:0016462,GO:0016787,GO:0016788,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032991,GO:0033554,GO:0034641,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1902494,GO:1905347,GO:1905348,GO:1990391 - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - ABC_tran k59_105834_1 436308.Nmar_1077 5.45e-69 211.0 arCOG10267@1|root,arCOG10267@2157|Archaea,41STA@651137|Thaumarchaeota 651137|Thaumarchaeota S SnoaL-like domain - - - - - - - - - - - - SnoaL_3 k59_1742063_1 1144310.PMI07_001133 2.23e-38 141.0 COG2159@1|root,COG2159@2|Bacteria,1R5PG@1224|Proteobacteria,2U2G9@28211|Alphaproteobacteria,4BG3R@82115|Rhizobiaceae 28211|Alphaproteobacteria S Amidohydrolase - - 4.1.1.45 ko:K03392 ko00380,ko01100,map00380,map01100 M00038 R04323 RC00779 ko00000,ko00001,ko00002,ko01000 - - - Amidohydro_2 k59_333132_1 1392490.JHZX01000001_gene2027 2.94e-84 263.0 COG3866@1|root,COG3866@2|Bacteria,4NH4E@976|Bacteroidetes,1HWKE@117743|Flavobacteriia 976|Bacteroidetes G pectate lyase - - 4.2.2.2 ko:K01728 ko00040,ko02024,map00040,map02024 - R02361,R06240 RC00049,RC00705 ko00000,ko00001,ko01000 - - - Pec_lyase_C k59_1177907_1 1123037.AUDE01000004_gene51 1.5e-79 248.0 COG1216@1|root,COG1216@2|Bacteria,4NSN9@976|Bacteroidetes,1I55W@117743|Flavobacteriia 976|Bacteroidetes S Glycosyltransferase like family 2 - - - - - - - - - - - - Glycos_transf_2 k59_1794489_1 279714.FuraDRAFT_2385 1.64e-29 114.0 COG4786@1|root,COG4786@2|Bacteria,1MVMA@1224|Proteobacteria,2VKFQ@28216|Betaproteobacteria,2KSD6@206351|Neisseriales 206351|Neisseriales N Belongs to the flagella basal body rod proteins family - - - ko:K02392 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - Flg_bb_rod,Flg_bbr_C k59_1794489_2 926567.TheveDRAFT_0615 5.93e-27 110.0 COG4786@1|root,COG4786@2|Bacteria,3TA5C@508458|Synergistetes 508458|Synergistetes N basal body rod protein - - - ko:K02392 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - Flg_bb_rod,Flg_bbr_C k59_1684982_1 1286093.C266_17441 6.76e-42 157.0 COG0491@1|root,COG0491@2|Bacteria,1MVC3@1224|Proteobacteria,2VICE@28216|Betaproteobacteria,1KC56@119060|Burkholderiaceae 28216|Betaproteobacteria S Metallo-beta-lactamase superfamily - - - - - - - - - - - - Lactamase_B,NUDIX k59_1684982_2 83406.HDN1F_14030 2.9e-12 72.0 COG0491@1|root,COG0491@2|Bacteria 2|Bacteria GM Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid - - 1.3.1.34,3.1.2.6 ko:K00219,ko:K01069 ko00620,map00620 - R01736 RC00004,RC00137 ko00000,ko00001,ko01000 - - - Aminotran_5,Lactamase_B,Rhodanese k59_1684982_3 1177179.A11A3_01822 2.54e-10 60.5 COG3030@1|root,COG3030@2|Bacteria,1MZJJ@1224|Proteobacteria,1S8XU@1236|Gammaproteobacteria,1XJWY@135619|Oceanospirillales 135619|Oceanospirillales S Protein affecting phage T7 exclusion by the F plasmid fxsA - - ko:K07113 - - - - ko00000 - - - FxsA k59_838153_1 1121015.N789_00810 7.92e-74 240.0 COG0119@1|root,COG0119@2|Bacteria,1MUNQ@1224|Proteobacteria,1RMWE@1236|Gammaproteobacteria,1X3PI@135614|Xanthomonadales 135614|Xanthomonadales E Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) leuA - 2.3.3.13 ko:K01649 ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230 M00432 R01213 RC00004,RC00470,RC02754 br01601,ko00000,ko00001,ko00002,ko01000 - - - HMGL-like,LeuA_dimer k59_1344532_1 1097668.BYI23_B010390 8.88e-92 289.0 COG0045@1|root,COG1042@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,1MW98@1224|Proteobacteria,2VI9R@28216|Betaproteobacteria,1K035@119060|Burkholderiaceae 28216|Betaproteobacteria C CoA-binding domain protein - - 6.2.1.13 ko:K01905,ko:K22224 ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120 - R00229,R00920 RC00004,RC00012,RC00014 ko00000,ko00001,ko01000,ko01004 - - - ATP-grasp_5,Acetyltransf_3,Acetyltransf_4,CoA_binding_2,Succ_CoA_lig k59_949395_1 1231185.BAMP01000083_gene3629 1.12e-28 114.0 COG0179@1|root,COG0179@2|Bacteria,1MUPF@1224|Proteobacteria,2VF8I@28211|Alphaproteobacteria,43PUY@69277|Phyllobacteriaceae 28211|Alphaproteobacteria Q Domain of unknown function (DUF2437) - - - - - - - - - - - - DUF2437,FAA_hydrolase k59_949396_1 574376.BAMA_05870 3.91e-59 188.0 COG1720@1|root,COG1720@2|Bacteria,1TSBR@1239|Firmicutes,4HHKH@91061|Bacilli,1ZGXW@1386|Bacillus 91061|Bacilli S Uncharacterised protein family UPF0066 - - - - - - - - - - - - UPF0066 k59_105859_2 1157943.KB892705_gene3761 4.39e-06 49.3 COG0665@1|root,COG0665@2|Bacteria,2GNAE@201174|Actinobacteria,233VS@1762|Mycobacteriaceae 201174|Actinobacteria E PFAM FAD dependent oxidoreductase - - - - - - - - - - - - DAO k59_615236_2 1316936.K678_03327 3.47e-36 129.0 COG2360@1|root,COG2360@2|Bacteria,1R9W8@1224|Proteobacteria,2U59K@28211|Alphaproteobacteria,2JS03@204441|Rhodospirillales 204441|Rhodospirillales O Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine aat - 2.3.2.6 ko:K00684 - - R03813,R11443,R11444 RC00055,RC00064 ko00000,ko01000 - - - Leu_Phe_trans k59_1233800_1 246197.MXAN_2017 6.56e-135 407.0 COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,42M9W@68525|delta/epsilon subdivisions,2WJ29@28221|Deltaproteobacteria,2YU3Z@29|Myxococcales 28221|Deltaproteobacteria O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner lon-2 - 3.4.21.53 ko:K01338 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - AAA,LON_substr_bdg,Lon_C k59_898577_1 926569.ANT_16910 1.03e-33 131.0 COG1508@1|root,COG1508@2|Bacteria,2G5VM@200795|Chloroflexi 200795|Chloroflexi K TIGRFAM RNA polymerase sigma-54 factor, RpoN - - - ko:K03092 ko02020,ko05111,map02020,map05111 - - - ko00000,ko00001,ko03021 - - - Sigma54_AID,Sigma54_CBD,Sigma54_DBD k59_1005026_1 330214.NIDE3057 1.07e-86 270.0 COG4122@1|root,COG4122@2|Bacteria 2|Bacteria E O-methyltransferase activity dop GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0006464,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0010498,GO:0016787,GO:0016810,GO:0016811,GO:0017076,GO:0018193,GO:0018205,GO:0019538,GO:0019941,GO:0030163,GO:0030554,GO:0032446,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0036211,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0051603,GO:0070490,GO:0070647,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575 3.5.1.119,6.3.1.19 ko:K13571,ko:K20814 - M00342 R11207 RC00090,RC00096 ko00000,ko00002,ko01000,ko03051 - - - Pup_ligase k59_275505_1 351348.Maqu_1762 3.13e-38 139.0 COG0482@1|root,COG0482@2|Bacteria,1MUT1@1224|Proteobacteria,1RMAK@1236|Gammaproteobacteria,464B7@72275|Alteromonadaceae 1236|Gammaproteobacteria J Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 mnmA GO:0001510,GO:0002097,GO:0002098,GO:0002143,GO:0003674,GO:0003824,GO:0004808,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016741,GO:0016782,GO:0016783,GO:0030488,GO:0032259,GO:0034227,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.8.1.13 ko:K00566 ko04122,map04122 - R08700 RC02313,RC02315 ko00000,ko00001,ko01000,ko03016 - - - tRNA_Me_trans k59_275505_2 1415778.JQMM01000001_gene1756 1.26e-24 99.8 COG2915@1|root,COG2915@2|Bacteria,1RI8B@1224|Proteobacteria,1RPCC@1236|Gammaproteobacteria,1J6HZ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S High frequency lysogenization protein HflD homolog hflD GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006950,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009898,GO:0016020,GO:0019897,GO:0019898,GO:0031234,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0071944,GO:0098552,GO:0098562 - ko:K07153 - - - - ko00000 - - - DUF489 k59_667491_2 876044.IMCC3088_2689 5.43e-69 216.0 COG4764@1|root,COG4764@2|Bacteria,1MVRK@1224|Proteobacteria,1RQ79@1236|Gammaproteobacteria 1236|Gammaproteobacteria S protein conserved in bacteria - - - - - - - - - - - - SLT k59_667491_3 1201290.M902_1809 6.82e-55 193.0 COG2268@1|root,COG2268@2|Bacteria,1QIR4@1224|Proteobacteria,42Q0N@68525|delta/epsilon subdivisions,2WJDJ@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Band 7 protein - - - ko:K07192 ko04910,map04910 - - - ko00000,ko00001,ko03036,ko04131,ko04147 - - - Band_7,Flot k59_1233804_1 1469607.KK073769_gene6275 4.35e-14 73.6 COG0705@1|root,COG0705@2|Bacteria,1FZY1@1117|Cyanobacteria,1HJH9@1161|Nostocales 1117|Cyanobacteria S PFAM Rhomboid family - - - - - - - - - - - - Rhomboid k59_1005034_1 1122137.AQXF01000005_gene1123 3.54e-40 135.0 COG0509@1|root,COG0509@2|Bacteria,1RGV7@1224|Proteobacteria,2U9BY@28211|Alphaproteobacteria 28211|Alphaproteobacteria E The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein gcvH - - ko:K02437 ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200 M00532 R01221 RC00022,RC02834 ko00000,ko00001,ko00002 - - - GCV_H k59_1005034_2 1122137.AQXF01000005_gene1122 4.64e-233 650.0 COG0403@1|root,COG0403@2|Bacteria,1MVC1@1224|Proteobacteria,2TR6C@28211|Alphaproteobacteria 28211|Alphaproteobacteria E The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor gcvPA - 1.4.4.2 ko:K00282 ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200 - R01221,R03425 RC00022,RC00929,RC02834,RC02880 ko00000,ko00001,ko01000 - - - GDC-P k59_1519459_1 1117958.PE143B_0123590 7.16e-14 70.9 COG0117@1|root,COG1985@1|root,COG0117@2|Bacteria,COG1985@2|Bacteria,1MUWT@1224|Proteobacteria,1RN2M@1236|Gammaproteobacteria 1236|Gammaproteobacteria H Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate ribD GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0006139,GO:0006725,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0008703,GO:0008835,GO:0009058,GO:0009110,GO:0009231,GO:0009451,GO:0009987,GO:0016070,GO:0016491,GO:0016614,GO:0016616,GO:0016787,GO:0016810,GO:0016814,GO:0017144,GO:0018130,GO:0019239,GO:0034641,GO:0036094,GO:0042364,GO:0042726,GO:0042727,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 1.1.1.193,3.5.4.26 ko:K01498,ko:K11752 ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024 M00125 R03458,R03459 RC00204,RC00933 ko00000,ko00001,ko00002,ko01000 - - iB21_1397.B21_00366,iECBD_1354.ECBD_3247,iECB_1328.ECB_00362,iECD_1391.ECD_00362,iECED1_1282.ECED1_0437,iECNA114_1301.ECNA114_0391,iECSF_1327.ECSF_0374,iEcolC_1368.EcolC_3219,iJN746.PP_0514,iLF82_1304.LF82_1880,iNRG857_1313.NRG857_01945,iYL1228.KPN_00366,ic_1306.c0524 RibD_C,dCMP_cyt_deam_1 k59_1519459_2 566466.NOR53_90 1.63e-70 216.0 COG1327@1|root,COG1327@2|Bacteria,1RE7V@1224|Proteobacteria,1S3P9@1236|Gammaproteobacteria,1J883@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria K Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes nrdR GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0005488,GO:0005524,GO:0006355,GO:0008144,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0017076,GO:0019219,GO:0019222,GO:0030554,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 - ko:K07738 - - - - ko00000,ko03000 - - - ATP-cone k59_105868_1 1484460.JSWG01000004_gene2551 4.72e-21 84.3 2CKK3@1|root,334WA@2|Bacteria,4NUPS@976|Bacteroidetes,1I56I@117743|Flavobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_105868_2 1046627.BZARG_1209 1.35e-56 191.0 COG0038@1|root,COG0517@1|root,COG0038@2|Bacteria,COG0517@2|Bacteria,4NFCF@976|Bacteroidetes,1HWJE@117743|Flavobacteriia 976|Bacteroidetes P Chloride channel protein - - - ko:K03281 - - - - ko00000 2.A.49 - - CBS,Voltage_CLC k59_1577033_1 351607.Acel_0883 6.57e-42 151.0 COG0388@1|root,COG0388@2|Bacteria,2H03Y@201174|Actinobacteria,4EVT7@85013|Frankiales 201174|Actinobacteria S Carbon-nitrogen hydrolase - - 3.5.5.1,3.5.5.7 ko:K01501,ko:K01502 ko00380,ko00460,ko00627,ko00643,ko00910,ko01120,map00380,map00460,map00627,map00643,map00910,map01120 - R00540,R01887,R03093,R03542,R05358,R05591,R07855 RC00315,RC00325,RC00617,RC00959,RC01336,RC02811 ko00000,ko00001,ko01000 - - - CN_hydrolase k59_1066246_1 555778.Hneap_0344 3.11e-58 182.0 COG0099@1|root,COG0099@2|Bacteria,1RD1G@1224|Proteobacteria,1S3NX@1236|Gammaproteobacteria,1WYHF@135613|Chromatiales 135613|Chromatiales J Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits rpsM - - ko:K02952 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S13 k59_615262_1 1088721.NSU_2773 1.47e-38 134.0 298YE@1|root,2ZW29@2|Bacteria,1N9JF@1224|Proteobacteria,2UHRA@28211|Alphaproteobacteria,2K6ST@204457|Sphingomonadales 204457|Sphingomonadales - - - - - - - - - - - - - - - k59_1005043_1 330214.NIDE1421 3.68e-92 283.0 COG0516@1|root,COG0517@1|root,COG0516@2|Bacteria,COG0517@2|Bacteria,3J0A1@40117|Nitrospirae 40117|Nitrospirae F Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth guaB - 1.1.1.205 ko:K00088 ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 M00050 R01130,R08240 RC00143,RC02207 ko00000,ko00001,ko00002,ko01000,ko04147 - - - CBS,IMPDH k59_1177936_1 459349.CLOAM0164 2.03e-20 95.9 COG1520@1|root,COG1520@2|Bacteria 2|Bacteria S amino acid activation for nonribosomal peptide biosynthetic process - - - - - - - - - - - - SBBP k59_49966_1 394.NGR_c19610 8.27e-08 57.8 COG0500@1|root,COG2226@2|Bacteria,1NWX3@1224|Proteobacteria,2TURQ@28211|Alphaproteobacteria,4BCPH@82115|Rhizobiaceae 28211|Alphaproteobacteria Q ubiquinone menaquinone biosynthesis methyltransferase - - - - - - - - - - - - Methyltransf_11,Methyltransf_25,Ubie_methyltran k59_949435_1 941639.BCO26_1898 2.79e-29 113.0 COG0127@1|root,COG0127@2|Bacteria,1V6RN@1239|Firmicutes,4HCP6@91061|Bacilli,1ZFJM@1386|Bacillus 91061|Bacilli F Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions rdgB GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009141,GO:0009143,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0055086,GO:0071704,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576 3.6.1.66 ko:K02428 ko00230,map00230 - R00426,R00720,R01855,R02100,R02720,R03531 RC00002 ko00000,ko00001,ko01000 - - - Ham1p_like k59_1005059_1 314287.GB2207_08251 3.26e-15 76.3 COG3160@1|root,COG3160@2|Bacteria,1RHBB@1224|Proteobacteria,1S420@1236|Gammaproteobacteria,1J6CV@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria K Belongs to the Rsd AlgQ family rsd GO:0000988,GO:0000989,GO:0003674,GO:0008150,GO:0009889,GO:0010556,GO:0016989,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0140110,GO:1903506,GO:2001141 - ko:K07740 - - - - ko00000 - - - Rsd_AlgQ k59_1344599_1 436308.Nmar_0083 2.01e-26 106.0 COG1903@1|root,arCOG04383@2157|Archaea,41S70@651137|Thaumarchaeota 651137|Thaumarchaeota H Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A cbiD - 2.1.1.195 ko:K02188 ko00860,ko01100,map00860,map01100 - R07773 RC00003,RC02051 ko00000,ko00001,ko01000 - - - CbiD k59_1344599_2 436308.Nmar_0084 2.66e-18 82.8 COG0702@1|root,arCOG03015@2157|Archaea,41T19@651137|Thaumarchaeota 651137|Thaumarchaeota M NAD(P)H-binding - - 1.6.5.3,1.6.99.3 ko:K00329,ko:K00356 ko00190,map00190 - R11945 RC00061 ko00000,ko00001,ko01000 - - - NAD_binding_10 k59_105906_1 555793.WSK_0289 8.79e-42 140.0 COG5447@1|root,COG5447@2|Bacteria,1N1KU@1224|Proteobacteria,2UFES@28211|Alphaproteobacteria,2K70S@204457|Sphingomonadales 204457|Sphingomonadales S Protein of unknown function (DUF1491) - - - - - - - - - - - - DUF1491 k59_390335_1 13690.CP98_03809 4.03e-79 250.0 COG1538@1|root,COG1538@2|Bacteria,1MXB2@1224|Proteobacteria,2U4BD@28211|Alphaproteobacteria,2K01H@204457|Sphingomonadales 204457|Sphingomonadales MU Outer membrane efflux protein - - - - - - - - - - - - OEP k59_496640_2 3075.A0A087SQ98 1.44e-24 101.0 2A9IB@1|root,2RYIR@2759|Eukaryota,37UCN@33090|Viridiplantae 33090|Viridiplantae I Catalyzes the second two steps of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylmonomethylethanolamine (PMME) to phosphatidyldimethylethanolamine (PDME) and of PDME to phosphatidylcholine (PC) - - 2.1.1.71 ko:K00550 ko00564,ko01100,ko01110,map00564,map01100,map01110 M00091 R01320,R03424 RC00003,RC00181,RC00496 ko00000,ko00001,ko00002,ko01000 - - - PEMT k59_105916_1 1122137.AQXF01000001_gene2749 6.57e-95 292.0 COG0624@1|root,COG0624@2|Bacteria,1MWJS@1224|Proteobacteria,2TUHT@28211|Alphaproteobacteria 28211|Alphaproteobacteria E COG0624 Acetylornithine deacetylase Succinyl-diaminopimelate desuccinylase and related deacylases - - - - - - - - - - - - M20_dimer,Peptidase_M20,Peptidase_M28 k59_1344611_1 1120959.ATXF01000004_gene2553 8.5e-21 95.5 COG0389@1|root,COG0389@2|Bacteria,2GKBI@201174|Actinobacteria,4FKWX@85023|Microbacteriaceae 201174|Actinobacteria L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII dinB - 2.7.7.7 ko:K02346 - - - - ko00000,ko01000,ko03400 - - - HHH_5,IMS,IMS_C,IMS_HHH k59_552225_1 1122137.AQXF01000005_gene1355 6.32e-155 449.0 COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,2TRMU@28211|Alphaproteobacteria 28211|Alphaproteobacteria NU Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB gspE - - ko:K02454 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - T2SSE,T2SSE_N k59_1119139_1 1229909.NSED_02730 1.7e-69 220.0 COG0351@1|root,arCOG00020@2157|Archaea,41SA1@651137|Thaumarchaeota 651137|Thaumarchaeota H Phosphomethylpyrimidine kinase - - 2.5.1.3,2.7.1.49,2.7.4.7 ko:K21219 ko00730,ko01100,map00730,map01100 - R03223,R03471,R04509,R10712 RC00002,RC00017,RC00224,RC03255,RC03397 ko00000,ko00001,ko01000 - - - Phos_pyr_kin,ThiP_synth k59_1288374_1 1123269.NX02_02645 4.88e-81 253.0 COG0578@1|root,COG0578@2|Bacteria,1MUMY@1224|Proteobacteria,2TU11@28211|Alphaproteobacteria,2K0SB@204457|Sphingomonadales 204457|Sphingomonadales C Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family glpD - 1.1.5.3 ko:K00111 ko00564,ko01110,map00564,map01110 - R00848 RC00029 ko00000,ko00001,ko01000 - - - DAO,DAO_C k59_441216_1 1121859.KB890758_gene1823 1.46e-96 292.0 28HT5@1|root,2Z803@2|Bacteria,4NQQY@976|Bacteroidetes,47UZY@768503|Cytophagia 976|Bacteroidetes L HpaII restriction endonuclease hpaIIR - 3.1.21.4 ko:K01155 - - - - ko00000,ko01000,ko02048 - - - RE_HpaII k59_778830_1 158500.BV97_04618 6.45e-11 64.7 COG1629@1|root,COG4771@2|Bacteria,1MWKN@1224|Proteobacteria,2U3VD@28211|Alphaproteobacteria,2K0FN@204457|Sphingomonadales 204457|Sphingomonadales P Protein involved in receptor activity and transport - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_898647_2 84531.JMTZ01000063_gene1831 3.28e-54 181.0 COG0535@1|root,COG0535@2|Bacteria,1MUQP@1224|Proteobacteria,1RMR1@1236|Gammaproteobacteria,1X32K@135614|Xanthomonadales 135614|Xanthomonadales H Belongs to the radical SAM superfamily. PqqE family pqqE - - ko:K06139 - - - - ko00000 - - - Fer4_12,Radical_SAM,SPASM k59_1686344_1 498211.CJA_2411 7.44e-190 545.0 COG0018@1|root,COG0018@2|Bacteria,1MU4J@1224|Proteobacteria,1RPRC@1236|Gammaproteobacteria,1FH4W@10|Cellvibrio 1236|Gammaproteobacteria J Arginyl tRNA synthetase N terminal dom argS GO:0003674,GO:0003824,GO:0004812,GO:0004814,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006420,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.19 ko:K01887 ko00970,map00970 M00359,M00360 R03646 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - iECABU_c1320.ECABU_c21380,iECNA114_1301.ECNA114_1940,iECSE_1348.ECSE_2111,iECSF_1327.ECSF_1736,iEcolC_1368.EcolC_1756,iJN746.PP_5089,iLF82_1304.LF82_0128,iNRG857_1313.NRG857_09405,iUMNK88_1353.UMNK88_2348,ic_1306.c2291 Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d k59_899820_1 604354.TSIB_0694 2.84e-51 176.0 COG0598@1|root,arCOG02265@2157|Archaea,2XTRP@28890|Euryarchaeota,243JI@183968|Thermococci 183968|Thermococci P Mediates influx of magnesium ions corA - - ko:K03284 - - - - ko00000,ko02000 1.A.35.1,1.A.35.3 - - CorA k59_161657_1 1116472.MGMO_53c00080 2.14e-19 84.0 COG0526@1|root,COG0526@2|Bacteria,1RDJB@1224|Proteobacteria,1S5WT@1236|Gammaproteobacteria,1XDT7@135618|Methylococcales 135618|Methylococcales CO COG0526 Thiol-disulfide isomerase and thioredoxins - - - - - - - - - - - - AhpC-TSA k59_1289679_1 111780.Sta7437_3714 4.08e-22 99.8 COG1696@1|root,COG1696@2|Bacteria,1FZXB@1117|Cyanobacteria,3VJAD@52604|Pleurocapsales 1117|Cyanobacteria M MBOAT, membrane-bound O-acyltransferase family - - - ko:K19294 - - - - ko00000 - - - MBOAT k59_1520778_1 1506583.JQJY01000002_gene1799 1.83e-143 418.0 COG0702@1|root,COG0702@2|Bacteria,4NFWH@976|Bacteroidetes,1I01X@117743|Flavobacteriia,2NSR7@237|Flavobacterium 976|Bacteroidetes GM Pfam:SusD - - - ko:K21572 - - - - ko00000,ko02000 8.A.46.1,8.A.46.3 - - SusD-like_3,SusD_RagB k59_1743404_1 290397.Adeh_3015 1.11e-15 78.2 COG1038@1|root,COG1038@2|Bacteria,1NW9R@1224|Proteobacteria,43BKE@68525|delta/epsilon subdivisions,2X6YE@28221|Deltaproteobacteria,2YYQ8@29|Myxococcales 28221|Deltaproteobacteria C Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second pyc - 6.4.1.1 ko:K01958 ko00020,ko00620,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00720,map01100,map01120,map01200,map01230 M00173 R00344 RC00040,RC00367 ko00000,ko00001,ko00002,ko01000 - - - Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2,HMGL-like,PYC_OADA k59_1743404_2 290397.Adeh_0250 1.7e-43 156.0 COG4799@1|root,COG4799@2|Bacteria,1MVAX@1224|Proteobacteria,43AEE@68525|delta/epsilon subdivisions,2WIRF@28221|Deltaproteobacteria,2YU6I@29|Myxococcales 28221|Deltaproteobacteria I Carboxyl transferase domain pccB - 2.1.3.1,2.1.3.15,6.4.1.3 ko:K01966,ko:K17489 ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200 M00373,M00741 R00353,R01859 RC00040,RC00097,RC00609 ko00000,ko00001,ko00002,ko01000 - - - Carboxyl_trans k59_1289687_1 411154.GFO_2133 6.27e-50 176.0 COG0366@1|root,COG0366@2|Bacteria,4NEXF@976|Bacteroidetes,1HX5N@117743|Flavobacteriia 976|Bacteroidetes G Belongs to the glycosyl hydrolase 13 family - - 3.2.1.133,3.2.1.135,3.2.1.54 ko:K01208,ko:K21575 ko00500,ko01100,map00500,map01100 - R02112,R03122,R11262 - ko00000,ko00001,ko01000 - GH13 - Alpha-amylase,Cyc-maltodext_C,Cyc-maltodext_N k59_107254_1 399739.Pmen_0272 7.69e-38 137.0 COG3675@1|root,COG3675@2|Bacteria,1NICA@1224|Proteobacteria,1SHG9@1236|Gammaproteobacteria,1YDR8@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria I Lipase (class 3) - - 3.1.1.3 ko:K01046 ko00561,ko01100,map00561,map01100 M00098 R02250,R02687 RC00020,RC00037,RC00041,RC00094 ko00000,ko00001,ko00002,ko01000 - - - Lipase_3 k59_334401_1 436308.Nmar_1612 1.52e-26 103.0 COG1985@1|root,arCOG01484@2157|Archaea,41SK2@651137|Thaumarchaeota 651137|Thaumarchaeota H RibD C-terminal domain - - 1.1.1.302 ko:K14654 ko00740,ko01100,map00740,map01100 - R09375,R09376 RC00933 ko00000,ko00001,ko01000 - - - RibD_C k59_107256_1 414684.RC1_2501 1.38e-13 66.6 COG3536@1|root,COG3536@2|Bacteria,1MZ5M@1224|Proteobacteria,2U9GJ@28211|Alphaproteobacteria,2JT01@204441|Rhodospirillales 204441|Rhodospirillales S Protein of unknown function (DUF971) - - - - - - - - - - - - DUF971 k59_107256_2 1265313.HRUBRA_02263 2.82e-111 327.0 COG0500@1|root,COG2226@2|Bacteria,1MX8I@1224|Proteobacteria,1RMAU@1236|Gammaproteobacteria,1J4ZD@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2- polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) ubiE GO:0003674,GO:0003824,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008425,GO:0008757,GO:0009058,GO:0009108,GO:0009233,GO:0009234,GO:0009987,GO:0016740,GO:0016741,GO:0030580,GO:0032259,GO:0042180,GO:0042181,GO:0043333,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901661,GO:1901663 2.1.1.163,2.1.1.201 ko:K03183 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116,M00117 R04990,R04993,R06859,R08774,R09736 RC00003,RC01253,RC01662 ko00000,ko00001,ko00002,ko01000 - - iAF1260.b3833,iBWG_1329.BWG_3511,iE2348C_1286.E2348C_4147,iEC042_1314.EC042_4213,iEC55989_1330.EC55989_4310,iECDH10B_1368.ECDH10B_4024,iECDH1ME8569_1439.ECDH1ME8569_3712,iECH74115_1262.ECH74115_5274,iECIAI1_1343.ECIAI1_4028,iECIAI39_1322.ECIAI39_3162,iECO103_1326.ECO103_4330,iECO111_1330.ECO111_4661,iECO26_1355.ECO26_4752,iECSE_1348.ECSE_4121,iECSP_1301.ECSP_4888,iECUMN_1333.ECUMN_4359,iECW_1372.ECW_m4135,iECs_1301.ECs4763,iEKO11_1354.EKO11_4524,iETEC_1333.ETEC_4110,iEcDH1_1363.EcDH1_4146,iEcE24377_1341.EcE24377A_4354,iEcHS_1320.EcHS_A4057,iEcSMS35_1347.EcSMS35_4216,iEcolC_1368.EcolC_4175,iG2583_1286.G2583_4633,iJO1366.b3833,iJR904.b3833,iSBO_1134.SBO_3847,iSDY_1059.SDY_3910,iSFV_1184.SFV_3665,iSF_1195.SF3911,iSFxv_1172.SFxv_4263,iSSON_1240.SSON_4008,iS_1188.S3843,iSbBS512_1146.SbBS512_E4305,iUMNK88_1353.UMNK88_4663,iWFL_1372.ECW_m4135,iY75_1357.Y75_RS17910,iZ_1308.Z5355 Ubie_methyltran k59_668793_1 1049564.TevJSym_bc00320 1.9e-15 71.2 COG0375@1|root,COG0375@2|Bacteria,1MZJH@1224|Proteobacteria,1S5WG@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Probably plays a role in a hydrogenase nickel cofactor insertion step hypA GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009898,GO:0010467,GO:0016020,GO:0016151,GO:0019538,GO:0019897,GO:0019898,GO:0031234,GO:0043167,GO:0043169,GO:0043170,GO:0044238,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0046872,GO:0046914,GO:0051604,GO:0071704,GO:0071944,GO:0098552,GO:0098562,GO:1901564 - ko:K04651 - - - - ko00000,ko03110 - - - HypA k59_668793_2 297246.lpp0868 1.8e-40 148.0 COG0475@1|root,COG0475@2|Bacteria,1RB9F@1224|Proteobacteria,1S398@1236|Gammaproteobacteria,1JDR9@118969|Legionellales 118969|Legionellales P Sodium/hydrogen exchanger family - - - - - - - - - - - - Na_H_Exchanger k59_1743408_1 1123360.thalar_02884 7.2e-86 257.0 COG1622@1|root,COG1622@2|Bacteria,1NZNI@1224|Proteobacteria,2UJSY@28211|Alphaproteobacteria 28211|Alphaproteobacteria C cytochrome c oxidase (Subunit II) - - - - - - - - - - - - - k59_1235042_1 864702.OsccyDRAFT_4169 1.27e-71 228.0 COG4976@1|root,COG4976@2|Bacteria,1GQBZ@1117|Cyanobacteria,1HHY0@1150|Oscillatoriales 1117|Cyanobacteria S Putative zinc binding domain - - - - - - - - - - - - Methyltransf_13,Methyltransf_14,Methyltransf_23 k59_1235042_2 365046.Rta_24860 1.6e-16 77.8 COG0451@1|root,COG0451@2|Bacteria,1PB4Y@1224|Proteobacteria,2VU66@28216|Betaproteobacteria,4AG0U@80864|Comamonadaceae 28216|Betaproteobacteria GM 3-beta hydroxysteroid dehydrogenase/isomerase family - - 5.1.3.2 ko:K01784 ko00052,ko00520,ko01100,map00052,map00520,map01100 M00361,M00362,M00632 R00291,R02984 RC00289 ko00000,ko00001,ko00002,ko01000 - - - Epimerase k59_950602_1 298655.KI912266_gene3725 1.92e-10 66.6 COG2124@1|root,COG2124@2|Bacteria,2GJ3T@201174|Actinobacteria 201174|Actinobacteria Q cytochrome P450 - - - - - - - - - - - - p450 k59_1179273_1 1303692.SFUL_4901 6.8e-16 83.2 COG4292@1|root,COG4292@2|Bacteria,2GJPB@201174|Actinobacteria 201174|Actinobacteria S Low temperature requirement ltrA - - - - - - - - - - - LtrA k59_1073647_2 1415778.JQMM01000001_gene842 4.95e-119 352.0 COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,1RN9T@1236|Gammaproteobacteria,1J4WE@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O COG0265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain degS GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006508,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0009897,GO:0009986,GO:0009987,GO:0010033,GO:0016020,GO:0016021,GO:0016787,GO:0017171,GO:0019538,GO:0030288,GO:0030313,GO:0031224,GO:0031226,GO:0031233,GO:0031975,GO:0033554,GO:0035966,GO:0035967,GO:0042221,GO:0042597,GO:0042802,GO:0043170,GO:0044238,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051716,GO:0051788,GO:0070011,GO:0070887,GO:0071218,GO:0071310,GO:0071575,GO:0071704,GO:0071944,GO:0098552,GO:0140096,GO:1901564 - ko:K04691,ko:K04772 - - - - ko00000,ko01000,ko01002 - - - PDZ_2,Trypsin_2 k59_1243179_1 666685.R2APBS1_1436 1.36e-75 231.0 COG0353@1|root,COG0353@2|Bacteria,1MV9Q@1224|Proteobacteria,1RN99@1236|Gammaproteobacteria,1X30Z@135614|Xanthomonadales 135614|Xanthomonadales L May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO recR - - ko:K06187 ko03440,map03440 - - - ko00000,ko00001,ko03400 - - - RecR,Toprim_4 k59_1017267_1 1056820.KB900663_gene3804 7.03e-80 255.0 COG3420@1|root,COG3420@2|Bacteria,1NNDG@1224|Proteobacteria,1SZ6G@1236|Gammaproteobacteria,2PPKM@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria P Periplasmic copper-binding protein (NosD) - - - - - - - - - - - - Beta_helix k59_1299723_1 1415778.JQMM01000001_gene1936 1.31e-90 276.0 COG0084@1|root,COG0084@2|Bacteria,1MXN8@1224|Proteobacteria,1RNCC@1236|Gammaproteobacteria,1J64M@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L TatD related DNase tatD GO:0000175,GO:0000302,GO:0000738,GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004529,GO:0004532,GO:0004536,GO:0004540,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006308,GO:0006725,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008296,GO:0008297,GO:0008310,GO:0008408,GO:0009056,GO:0009057,GO:0009636,GO:0009987,GO:0010035,GO:0016070,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0016896,GO:0019439,GO:0034641,GO:0034655,GO:0042221,GO:0042493,GO:0042542,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046677,GO:0046700,GO:0046872,GO:0050896,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0140097,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901700 - ko:K03424 - - - - ko00000,ko01000 - - - TatD_DNase k59_791234_1 338963.Pcar_0396 9.88e-42 157.0 COG3210@1|root,COG3420@1|root,COG3210@2|Bacteria,COG3420@2|Bacteria,1R4VM@1224|Proteobacteria,43CFZ@68525|delta/epsilon subdivisions,2WQIB@28221|Deltaproteobacteria,43TE1@69541|Desulfuromonadales 28221|Deltaproteobacteria U Concanavalin A-like lectin/glucanases superfamily - - - ko:K12287 - - - - ko00000,ko02044 - - - Laminin_G_3 k59_1469188_1 1122137.AQXF01000001_gene3390 4.11e-42 145.0 COG3176@1|root,COG3176@2|Bacteria,1MWIM@1224|Proteobacteria,2TUVA@28211|Alphaproteobacteria 28211|Alphaproteobacteria S hemolysin olsB - 2.3.2.30 ko:K22310 - - - - ko00000,ko01000 - - - Acetyltransf_5 k59_1469188_2 1434929.X946_357 1.16e-32 119.0 COG0220@1|root,COG0220@2|Bacteria,1QTX5@1224|Proteobacteria,2WH0A@28216|Betaproteobacteria,1K3DS@119060|Burkholderiaceae 28216|Betaproteobacteria J Protein of unknown function (DUF938) - - - - - - - - - - - - DUF938 k59_1243185_1 1117379.BABA_12031 2.19e-15 79.3 COG1668@1|root,COG1668@2|Bacteria,1V5UX@1239|Firmicutes,4HJFQ@91061|Bacilli 91061|Bacilli CP ABC-2 family transporter protein - - - - - - - - - - - - ABC2_membrane_2 k59_1299731_1 305900.GV64_16110 9.61e-110 344.0 COG0249@1|root,COG0249@2|Bacteria,1MUGX@1224|Proteobacteria,1RNW3@1236|Gammaproteobacteria,1XI9K@135619|Oceanospirillales 135619|Oceanospirillales L that it carries out the mismatch recognition step. This protein has a weak ATPase activity mutS - - ko:K03555 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V k59_791244_1 404589.Anae109_2221 4.6e-78 261.0 COG0085@1|root,COG0085@2|Bacteria,1MUC4@1224|Proteobacteria,43DMZ@68525|delta/epsilon subdivisions,2WIW5@28221|Deltaproteobacteria,2YUEA@29|Myxococcales 28221|Deltaproteobacteria K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoB GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234 2.7.7.6 ko:K03043 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7 k59_1525684_1 378806.STAUR_8186 2.95e-68 226.0 COG4805@1|root,COG4805@2|Bacteria,1MUBX@1224|Proteobacteria,43BBS@68525|delta/epsilon subdivisions,2X6QY@28221|Deltaproteobacteria,2YU79@29|Myxococcales 28221|Deltaproteobacteria S Bacterial protein of unknown function (DUF885) - - - - - - - - - - - - DUF885 k59_1243194_2 1121422.AUMW01000001_gene2416 1.69e-12 67.8 COG1028@1|root,COG1028@2|Bacteria,1UETI@1239|Firmicutes,24BBC@186801|Clostridia,264PK@186807|Peptococcaceae 186801|Clostridia IQ PFAM short chain dehydrogenase - - 1.1.1.100 ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 k59_395716_2 457412.RSAG_01202 3.41e-12 63.2 COG0236@1|root,COG0236@2|Bacteria,1TU8E@1239|Firmicutes,25P60@186801|Clostridia,3WKUX@541000|Ruminococcaceae 186801|Clostridia IQ Carrier of the growing fatty acid chain in fatty acid biosynthesis - - - ko:K02078 - - - - ko00000,ko00001 - - - PP-binding k59_113287_1 44251.PDUR_20065 4.06e-15 77.0 COG0751@1|root,COG0751@2|Bacteria,1TNZ7@1239|Firmicutes,4H9NT@91061|Bacilli,26S3M@186822|Paenibacillaceae 91061|Bacilli J Glycyl-tRNA synthetase beta subunit glyS - 6.1.1.14 ko:K01879 ko00970,map00970 M00360 R03654 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DALR_1,tRNA_synt_2f k59_113287_2 1042377.AFPJ01000012_gene1353 3.55e-37 134.0 COG0752@1|root,COG0752@2|Bacteria,1MVCJ@1224|Proteobacteria,1RMYI@1236|Gammaproteobacteria,4640E@72275|Alteromonadaceae 1236|Gammaproteobacteria J glycyl-tRNA synthetase alpha subunit glyQ GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 6.1.1.14 ko:K01878 ko00970,map00970 M00360 R03654 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iAF1260.b3560,iJO1366.b3560,iPC815.YPO4072,iY75_1357.Y75_RS19360 tRNA-synt_2e k59_254_1 1037409.BJ6T_84920 3.72e-10 60.8 COG0604@1|root,COG0604@2|Bacteria,1MXUX@1224|Proteobacteria,2TTWF@28211|Alphaproteobacteria,3JTZF@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria C Zinc-binding dehydrogenase - - - - - - - - - - - - ADH_N,ADH_zinc_N k59_254_2 1131813.AQVT01000001_gene1785 2.49e-36 133.0 COG0265@1|root,COG0265@2|Bacteria,1MURF@1224|Proteobacteria,2TUVW@28211|Alphaproteobacteria,1JTF7@119045|Methylobacteriaceae 28211|Alphaproteobacteria O Trypsin-like peptidase domain MA20_20705 - - - - - - - - - - - PDZ_2,Trypsin_2 k59_508745_1 768706.Desor_4558 1.57e-06 52.4 COG3409@1|root,COG3409@2|Bacteria,1TT2K@1239|Firmicutes,24965@186801|Clostridia,261US@186807|Peptococcaceae 186801|Clostridia M peptidoglycan-binding domain-containing protein - - - - - - - - - - - - LysM,NLPC_P60,PG_binding_1 k59_508745_2 1279017.AQYJ01000029_gene3463 7.89e-17 88.6 COG1752@1|root,COG1752@2|Bacteria,1PDQ2@1224|Proteobacteria,1RMWI@1236|Gammaproteobacteria,4641T@72275|Alteromonadaceae 1236|Gammaproteobacteria S esterase of the alpha-beta hydrolase superfamily - - - ko:K07001 - - - - ko00000 - - - Patatin k59_1130292_1 1122604.JONR01000002_gene1654 2.71e-14 72.8 COG0108@1|root,COG0108@2|Bacteria,1MU8P@1224|Proteobacteria,1RQ49@1236|Gammaproteobacteria,1X31N@135614|Xanthomonadales 135614|Xanthomonadales H Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate ribB - 3.5.4.25,4.1.99.12 ko:K14652 ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110 M00125,M00840 R00425,R07281 RC00293,RC01792,RC01815,RC02504 ko00000,ko00001,ko00002,ko01000 - - - DHBP_synthase,GTP_cyclohydro2 k59_1130292_2 697282.Mettu_0904 8.07e-53 171.0 COG0054@1|root,COG0054@2|Bacteria,1RD9J@1224|Proteobacteria,1S3WD@1236|Gammaproteobacteria,1XF3G@135618|Methylococcales 135618|Methylococcales H Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin ribH - 2.5.1.78 ko:K00794 ko00740,ko01100,ko01110,map00740,map01100,map01110 M00125 R04457 RC00960 ko00000,ko00001,ko00002,ko01000 - - - DMRL_synthase k59_282846_2 1123261.AXDW01000004_gene2880 4.85e-59 194.0 COG0607@1|root,COG0664@1|root,COG0607@2|Bacteria,COG0664@2|Bacteria,1R9Q1@1224|Proteobacteria,1RSKD@1236|Gammaproteobacteria,1X71M@135614|Xanthomonadales 135614|Xanthomonadales PT Cyclic nucleotide-monophosphate binding domain - - - - - - - - - - - - Rhodanese,cNMP_binding k59_621726_1 1415778.JQMM01000001_gene1948 1.03e-28 112.0 COG2304@1|root,COG2304@2|Bacteria,1MXQ7@1224|Proteobacteria,1RMDX@1236|Gammaproteobacteria,1J577@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S protein containing a von Willebrand factor type A (vWA) domain - - - ko:K07114 - - - - ko00000,ko02000 1.A.13.2.2,1.A.13.2.3 - - VWA,VWA_2 k59_621726_2 1027273.GZ77_00995 1.07e-13 72.0 COG2304@1|root,COG2304@2|Bacteria,1MW51@1224|Proteobacteria,1RMD3@1236|Gammaproteobacteria,1XI5E@135619|Oceanospirillales 135619|Oceanospirillales S von Willebrand factor type A domain - - - ko:K07114 - - - - ko00000,ko02000 1.A.13.2.2,1.A.13.2.3 - - TPR_1,TPR_2,VWA_2 k59_1695175_1 521674.Plim_3270 3.47e-15 78.6 COG3219@1|root,COG3219@2|Bacteria,2J0EG@203682|Planctomycetes 203682|Planctomycetes S Putative DNA-binding domain - - - - - - - - - - - - DUF2063 k59_734816_1 1229909.NSED_06825 1.15e-97 296.0 COG0585@1|root,arCOG04252@2157|Archaea,41S7C@651137|Thaumarchaeota 651137|Thaumarchaeota J tRNA pseudouridine synthase - - 5.4.99.27 ko:K06176 - - - - ko00000,ko01000,ko03016 - - - TruD k59_791297_1 1121406.JAEX01000001_gene292 2.06e-19 91.3 COG0705@1|root,COG0705@2|Bacteria,1N258@1224|Proteobacteria,42UB4@68525|delta/epsilon subdivisions,2WQJ3@28221|Deltaproteobacteria,2MBT8@213115|Desulfovibrionales 28221|Deltaproteobacteria S PFAM Rhomboid family protein - - - - - - - - - - - - Rhomboid k59_1073692_1 1304275.C41B8_10148 3.96e-11 62.4 COG0084@1|root,COG0084@2|Bacteria,1MXN8@1224|Proteobacteria,1RNCC@1236|Gammaproteobacteria 1236|Gammaproteobacteria L 3'-5' exonuclease that prefers single-stranded DNA and RNA. May play a role in the H(2)O(2)-induced DNA damage repair tatD GO:0000175,GO:0000302,GO:0000738,GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004529,GO:0004532,GO:0004536,GO:0004540,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006308,GO:0006725,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008296,GO:0008297,GO:0008310,GO:0008408,GO:0009056,GO:0009057,GO:0009636,GO:0009987,GO:0010035,GO:0016070,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0016896,GO:0019439,GO:0034641,GO:0034655,GO:0042221,GO:0042493,GO:0042542,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046677,GO:0046700,GO:0046872,GO:0050896,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0140097,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901700 - ko:K03424 - - - - ko00000,ko01000 - - - TatD_DNase k59_1073692_2 580332.Slit_0721 4.54e-82 254.0 COG0842@1|root,COG0842@2|Bacteria,1PX28@1224|Proteobacteria,2VYZC@28216|Betaproteobacteria 28216|Betaproteobacteria V ABC-2 family transporter protein - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane,ABC2_membrane_3 k59_1017342_2 1122137.AQXF01000005_gene1253 1.89e-54 183.0 COG2207@1|root,COG2207@2|Bacteria,1MX23@1224|Proteobacteria,2TT6H@28211|Alphaproteobacteria 28211|Alphaproteobacteria K transcriptional regulator, AraC family - - - - - - - - - - - - Arabinose_bd,HTH_18 k59_280_2 485918.Cpin_1978 0.000497 43.5 COG3779@1|root,COG3779@2|Bacteria,4NSS5@976|Bacteroidetes,1IVH1@117747|Sphingobacteriia 976|Bacteroidetes S Uncharacterized protein conserved in bacteria (DUF2314) - - - - - - - - - - - - DUF2314 k59_113319_1 1057002.KB905372_gene5965 9.39e-165 474.0 COG5659@1|root,COG5659@2|Bacteria,1MXSV@1224|Proteobacteria,2TRKD@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Transposase - - - - - - - - - - - - DDE_5 k59_1186735_1 1160137.KB907307_gene3220 0.00047 48.1 COG1496@1|root,COG1496@2|Bacteria,2GN1M@201174|Actinobacteria,4FWAA@85025|Nocardiaceae 201174|Actinobacteria S Belongs to the multicopper oxidase YfiH RL5 family yfiH GO:0003674,GO:0005488,GO:0005507,GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0043167,GO:0043169,GO:0044464,GO:0046872,GO:0046914,GO:0071944 - ko:K05810 - - - - ko00000,ko01000 - - - Cu-oxidase_4 k59_904233_1 990285.RGCCGE502_06209 3.8e-30 122.0 COG1138@1|root,COG1138@2|Bacteria,1MUQS@1224|Proteobacteria,2TRNG@28211|Alphaproteobacteria,4B8ZH@82115|Rhizobiaceae 28211|Alphaproteobacteria O Cytochrome c-type biogenesis protein ccmF - - ko:K02198 - - - - ko00000,ko02000 9.B.14.1 - - CcmF_C,Cytochrom_C_asm k59_339332_1 265072.Mfla_2252 7.88e-92 285.0 COG0548@1|root,COG1246@1|root,COG1396@1|root,COG0548@2|Bacteria,COG1246@2|Bacteria,COG1396@2|Bacteria,1MUUP@1224|Proteobacteria,2VGZC@28216|Betaproteobacteria,2KKM3@206350|Nitrosomonadales 206350|Nitrosomonadales E Belongs to the acetyltransferase family. ArgA subfamily argA - 2.3.1.1 ko:K14682 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028 R00259 RC00004,RC00064 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase,Acetyltransf_1,HTH_31 k59_1130316_1 436308.Nmar_1571 5.3e-103 304.0 COG1634@1|root,arCOG04303@2157|Archaea,41SKX@651137|Thaumarchaeota 651137|Thaumarchaeota H Catalyzes the transfer of diphosphate from ATP to 6- hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6- hydroxymethyl-7,8-dihydropterin diphosphate (6-HMDP) mptE - 2.7.6.3 ko:K07142 ko00790,map00790 - R03503 RC00002,RC00017 ko00000,ko00001,ko01000 - - - MAF_flag10 k59_1752185_1 694429.Pyrfu_1968 1.23e-26 104.0 COG1522@1|root,arCOG01580@2157|Archaea,2XQYS@28889|Crenarchaeota 28889|Crenarchaeota K PFAM regulatory protein AsnC Lrp family - - - ko:K03718 - - - - ko00000,ko03000 - - - AsnC_trans_reg,HTH_24,HTH_AsnC-type k59_452665_1 1144275.COCOR_06731 2.8e-149 438.0 COG0438@1|root,COG0438@2|Bacteria,1MYTB@1224|Proteobacteria,42MCA@68525|delta/epsilon subdivisions,2WJVX@28221|Deltaproteobacteria 28221|Deltaproteobacteria M PFAM Glycosyl transferase, group 1 - - 2.4.1.245 ko:K13057 ko00500,ko01100,map00500,map01100 - R08946,R10525,R11306 RC00005,RC00049,RC02748 ko00000,ko00001,ko01000 - GT4 - Glycos_transf_1 k59_1695580_1 1158292.JPOE01000002_gene2994 1.07e-27 112.0 COG0639@1|root,COG0639@2|Bacteria,1MV10@1224|Proteobacteria,2VHV6@28216|Betaproteobacteria,1KJHU@119065|unclassified Burkholderiales 28216|Betaproteobacteria T Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP apaH - 3.6.1.41 ko:K01525 ko00230,map00230 - R00125 RC00002 ko00000,ko00001,ko01000 - - - Metallophos k59_735420_1 744979.R2A130_0517 5.12e-13 74.7 COG0642@1|root,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,2TUYS@28211|Alphaproteobacteria 28211|Alphaproteobacteria T Histidine kinase MA20_25925 - 2.7.13.3 ko:K07716 ko02020,ko04112,map02020,map04112 M00511 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA k59_735422_1 1449069.JMLO01000002_gene4733 2.87e-27 114.0 COG1020@1|root,COG1020@2|Bacteria,2GPHZ@201174|Actinobacteria,4FURZ@85025|Nocardiaceae 201174|Actinobacteria Q Belongs to the long-chain O-acyltransferase family - GO:0000302,GO:0001666,GO:0003674,GO:0003824,GO:0004144,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006629,GO:0006638,GO:0006639,GO:0006641,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008374,GO:0008610,GO:0009058,GO:0009628,GO:0009987,GO:0010035,GO:0016020,GO:0016411,GO:0016740,GO:0016746,GO:0016747,GO:0019432,GO:0030312,GO:0036293,GO:0040007,GO:0042221,GO:0042493,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044403,GO:0044419,GO:0044464,GO:0045017,GO:0046460,GO:0046463,GO:0046486,GO:0047196,GO:0050896,GO:0051704,GO:0070482,GO:0071704,GO:0071731,GO:0071944,GO:0097366,GO:1901576,GO:1901698,GO:1901700 2.3.1.20 ko:K00635 ko00561,ko01100,map00561,map01100 M00089 R02251 RC00004,RC00041 ko00000,ko00001,ko00002,ko01000 - - - DUF1298,WES_acyltransf k59_396223_1 1122137.AQXF01000006_gene746 4.82e-289 796.0 COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2TQR1@28211|Alphaproteobacteria 28211|Alphaproteobacteria C belongs to the aldehyde dehydrogenase family gabD GO:0000166,GO:0001505,GO:0003674,GO:0003824,GO:0004777,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006105,GO:0006520,GO:0006536,GO:0006538,GO:0006540,GO:0006807,GO:0008150,GO:0008152,GO:0009013,GO:0009056,GO:0009063,GO:0009064,GO:0009065,GO:0009448,GO:0009450,GO:0009987,GO:0016054,GO:0016491,GO:0016620,GO:0016903,GO:0017144,GO:0019752,GO:0032787,GO:0036094,GO:0042133,GO:0042135,GO:0043436,GO:0043648,GO:0043649,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044464,GO:0046395,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0065007,GO:0065008,GO:0071704,GO:0072329,GO:0097159,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 1.2.1.16,1.2.1.20,1.2.1.79 ko:K00135 ko00250,ko00310,ko00350,ko00650,ko00760,ko01100,ko01120,map00250,map00310,map00350,map00650,map00760,map01100,map01120 M00027 R00713,R00714,R02401 RC00080 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_791938_2 314287.GB2207_05529 1e-43 153.0 COG1090@1|root,COG1090@2|Bacteria,1MUB4@1224|Proteobacteria,1RN6A@1236|Gammaproteobacteria,1J5PT@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S nucleoside-diphosphate sugar epimerase yfcH - - ko:K07071 - - - - ko00000 - - - DUF1731,Epimerase k59_1582720_2 1149133.ppKF707_5492 6.69e-16 72.4 2DMSD@1|root,32TCS@2|Bacteria,1QEH1@1224|Proteobacteria,1TB6S@1236|Gammaproteobacteria,1YH1H@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria S Protein of unknown function (DUF1161) - - - - - - - - - - - - DUF1161 k59_1413239_1 472759.Nhal_1619 8.78e-57 196.0 COG0243@1|root,COG3383@1|root,COG0243@2|Bacteria,COG3383@2|Bacteria,1MW3N@1224|Proteobacteria,1RN6N@1236|Gammaproteobacteria,1X01G@135613|Chromatiales 135613|Chromatiales C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - 1.17.1.9 ko:K00123 ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200 - R00519 RC02796 ko00000,ko00001,ko01000 - - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding k59_1413239_2 1286106.MPL1_02548 5.53e-56 177.0 COG0437@1|root,COG0437@2|Bacteria,1MU5T@1224|Proteobacteria,1RRAN@1236|Gammaproteobacteria,461YS@72273|Thiotrichales 72273|Thiotrichales C 4Fe-4S dicluster domain - - - ko:K00124 ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200 - R00519 RC02796 ko00000,ko00001 - - - Fer4_7 k59_339933_1 1121396.KB892902_gene2275 1.42e-25 110.0 COG2909@1|root,COG3629@1|root,COG2909@2|Bacteria,COG3629@2|Bacteria,1ND43@1224|Proteobacteria,42Q70@68525|delta/epsilon subdivisions,2WKU1@28221|Deltaproteobacteria,2MMVA@213118|Desulfobacterales 28221|Deltaproteobacteria KT Transcriptional regulatory protein, C terminal - - - - - - - - - - - - BTAD,Trans_reg_C k59_735463_1 292.DM42_6053 1.11e-13 73.9 COG1028@1|root,COG1028@2|Bacteria,1MU6X@1224|Proteobacteria,2VJ3S@28216|Betaproteobacteria,1JZTR@119060|Burkholderiaceae 28216|Betaproteobacteria IQ reductase - - 1.1.1.100 ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 k59_1582741_1 1232410.KI421412_gene3 5.76e-06 53.1 COG1309@1|root,COG1309@2|Bacteria,1N0GT@1224|Proteobacteria,42UYU@68525|delta/epsilon subdivisions,2WQMK@28221|Deltaproteobacteria,43UZA@69541|Desulfuromonadales 28221|Deltaproteobacteria K Bacterial regulatory proteins, tetR family - - - - - - - - - - - - TetR_C_10,TetR_N k59_1582741_2 378806.STAUR_6702 2.55e-40 140.0 COG3837@1|root,COG3837@2|Bacteria,1N15Q@1224|Proteobacteria 1224|Proteobacteria S PFAM Cupin 2, conserved barrel domain protein manC - - - - - - - - - - - Cupin_2 k59_1582741_3 1122137.AQXF01000001_gene3256 3.8e-75 234.0 COG0484@1|root,COG0484@2|Bacteria,1MVMS@1224|Proteobacteria,2TRZ1@28211|Alphaproteobacteria 28211|Alphaproteobacteria O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins dnaJ - - ko:K03686 - - - - ko00000,ko03029,ko03110 - - - DnaJ,DnaJ_C,DnaJ_CXXCXGXG k59_678776_1 316274.Haur_1665 1.32e-32 118.0 COG1725@1|root,COG1725@2|Bacteria,2G7C5@200795|Chloroflexi 200795|Chloroflexi K PFAM regulatory protein GntR HTH - - - ko:K07979 - - - - ko00000,ko03000 - - - GntR k59_1187226_1 158500.BV97_05062 6.23e-25 102.0 COG1216@1|root,COG1216@2|Bacteria,1RDAK@1224|Proteobacteria,2UBKE@28211|Alphaproteobacteria,2K0ZU@204457|Sphingomonadales 204457|Sphingomonadales S Glycosyltransferase like family 2 - - - - - - - - - - - - Glycos_transf_2 k59_848338_1 886293.Sinac_1351 2.11e-74 244.0 COG0058@1|root,COG0058@2|Bacteria,2IY0J@203682|Planctomycetes 203682|Planctomycetes G COG0058 Glucan phosphorylase - - 2.4.1.1 ko:K00688 ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931 - R02111 - ko00000,ko00001,ko01000 - GT35 - DUF3417,Phosphorylase k59_735473_1 1209072.ALBT01000030_gene2247 1.65e-13 70.9 COG0635@1|root,COG0635@2|Bacteria,1MU76@1224|Proteobacteria,1RN6I@1236|Gammaproteobacteria,1FGUB@10|Cellvibrio 1236|Gammaproteobacteria H Involved in the biosynthesis of porphyrin-containing compound yggW GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 - - - - - - - - - - HemN_C,Radical_SAM k59_735473_3 243277.VC_0309 1.01e-05 46.6 COG0043@1|root,COG0043@2|Bacteria,1MU62@1224|Proteobacteria,1RNH8@1236|Gammaproteobacteria,1XUXR@135623|Vibrionales 135623|Vibrionales H Belongs to the UbiD family ubiD GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0008694,GO:0009058,GO:0009108,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901661,GO:1901663 4.1.1.98 ko:K03182 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00117 R04985,R04986 RC00391 ko00000,ko00001,ko00002,ko01000 - - - UbiD k59_1300429_1 768671.ThimaDRAFT_1961 1.93e-49 178.0 COG1020@1|root,COG1020@2|Bacteria,1QK4F@1224|Proteobacteria,1RPAG@1236|Gammaproteobacteria,1WW5W@135613|Chromatiales 1236|Gammaproteobacteria Q TIGRFAM Amino acid adenylation - - - - - - - - - - - - AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase k59_678800_2 436308.Nmar_1319 5.52e-159 447.0 COG0863@1|root,arCOG00115@2157|Archaea,41SZP@651137|Thaumarchaeota 651137|Thaumarchaeota L DNA methylase - - 2.1.1.113,2.1.1.72 ko:K00571,ko:K00590 - - - - ko00000,ko01000,ko02048 - - - N6_N4_Mtase k59_848345_1 1120953.AUBH01000008_gene197 1.01e-30 125.0 COG2199@1|root,COG2199@2|Bacteria,1NV1F@1224|Proteobacteria,1T5PE@1236|Gammaproteobacteria 1236|Gammaproteobacteria T diguanylate cyclase - - - - - - - - - - - - 7TMR-DISMED2,7TMR-DISM_7TM,GGDEF k59_113896_1 76114.ebA2478 2.8e-31 124.0 COG3039@1|root,COG3039@2|Bacteria,1MUVI@1224|Proteobacteria,2VK9J@28216|Betaproteobacteria,2KUE1@206389|Rhodocyclales 206389|Rhodocyclales L COG3666 Transposase and inactivated derivatives - - - - - - - - - - - - DDE_Tnp_1,DUF772 k59_1187244_1 523791.Kkor_1190 2.11e-106 320.0 COG0304@1|root,COG0304@2|Bacteria,1MU1X@1224|Proteobacteria,1RMDE@1236|Gammaproteobacteria,1XHKS@135619|Oceanospirillales 135619|Oceanospirillales I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP fabF - 2.3.1.179 ko:K09458 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119 RC00039,RC02728,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Ketoacyl-synt_C,ketoacyl-synt k59_226827_1 1463858.JOHR01000008_gene3100 3.98e-13 70.1 COG0739@1|root,COG0739@2|Bacteria,2GM7Q@201174|Actinobacteria 201174|Actinobacteria M peptidase mepA - - ko:K21471 - - - - ko00000,ko01000,ko01002,ko01011 - - - Peptidase_M23 k59_226827_2 565045.NOR51B_2317 3.39e-12 67.4 COG1664@1|root,COG1664@2|Bacteria,1PDPX@1224|Proteobacteria,1S9XY@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Integral membrane protein CcmA involved in cell shape determination - - - - - - - - - - - - Bactofilin k59_886_1 1485544.JQKP01000004_gene451 7.71e-40 141.0 COG0501@1|root,COG0501@2|Bacteria,1MUV4@1224|Proteobacteria,2VIVB@28216|Betaproteobacteria,44VBA@713636|Nitrosomonadales 28216|Betaproteobacteria O Belongs to the peptidase M48B family htpX - - ko:K03799 - M00743 - - ko00000,ko00002,ko01000,ko01002 - - - Peptidase_M48 k59_886_2 768671.ThimaDRAFT_0117 0.000323 42.0 COG5113@1|root,COG3236@2|Bacteria,1RCXE@1224|Proteobacteria,1S8DV@1236|Gammaproteobacteria 1236|Gammaproteobacteria O protein conserved in bacteria - - - ko:K09935 - - - - ko00000 - - - DUF1768 k59_735481_1 1370122.JHXQ01000011_gene1405 2.64e-05 43.9 COG0198@1|root,COG0198@2|Bacteria,1MZQD@1224|Proteobacteria,2UC6Y@28211|Alphaproteobacteria,4BFJ2@82115|Rhizobiaceae 28211|Alphaproteobacteria J One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit rplX GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02895 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - KOW,ribosomal_L24 k59_735481_2 525904.Tter_0727 3.51e-82 248.0 COG0094@1|root,COG0094@2|Bacteria,2NP65@2323|unclassified Bacteria 2|Bacteria J This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits rplE GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02931 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L5,Ribosomal_L5_C k59_735481_3 338963.Pcar_0714 1.5e-21 85.9 COG0199@1|root,COG0199@2|Bacteria,1PDMJ@1224|Proteobacteria,42VCE@68525|delta/epsilon subdivisions,2WR7W@28221|Deltaproteobacteria,43VH4@69541|Desulfuromonadales 28221|Deltaproteobacteria J Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site rpsN GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02954 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S14 k59_735481_4 795359.TOPB45_0767 2.79e-40 138.0 COG0096@1|root,COG0096@2|Bacteria,2GHUB@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria J One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit rpsH - - ko:K02994 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S8 k59_735481_5 273068.TTE2276 3.05e-64 202.0 COG0097@1|root,COG0097@2|Bacteria,1V1FC@1239|Firmicutes,2496R@186801|Clostridia,42GCD@68295|Thermoanaerobacterales 186801|Clostridia J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center rplF - - ko:K02933 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L6 k59_735482_1 626887.J057_07291 6.99e-102 303.0 COG0861@1|root,COG0861@2|Bacteria,1MWC9@1224|Proteobacteria,1T1GE@1236|Gammaproteobacteria,4670C@72275|Alteromonadaceae 1236|Gammaproteobacteria P Integral membrane protein TerC family ygdQ GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - - - - - - - - - - TerC k59_283576_1 1049564.TevJSym_aa02290 3.41e-109 338.0 COG0013@1|root,COG0013@2|Bacteria,1MU9A@1224|Proteobacteria,1RMWZ@1236|Gammaproteobacteria,1J58G@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain alaS GO:0001130,GO:0001131,GO:0001141,GO:0001217,GO:0002161,GO:0002196,GO:0003674,GO:0003700,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006355,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006450,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009451,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016070,GO:0016597,GO:0016787,GO:0016788,GO:0016874,GO:0016875,GO:0019219,GO:0019222,GO:0019538,GO:0019752,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0042802,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045934,GO:0046483,GO:0046872,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0052689,GO:0060255,GO:0065007,GO:0065008,GO:0071704,GO:0080090,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:0140110,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 6.1.1.7 ko:K01872 ko00970,map00970 M00359,M00360 R03038 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iECABU_c1320.ECABU_c29670,iECED1_1282.ECED1_3146,iEcHS_1320.EcHS_A2833,iJN746.PP_4474 DHHA1,tRNA-synt_2c,tRNA_SAD k59_1187262_1 1207063.P24_02281 2.66e-93 285.0 COG0247@1|root,COG0247@2|Bacteria,1MWTK@1224|Proteobacteria,2U059@28211|Alphaproteobacteria,2JQVN@204441|Rhodospirillales 204441|Rhodospirillales C Cysteine-rich domain - - - - - - - - - - - - CCG k59_1695665_1 935863.AWZR01000013_gene1449 1.04e-66 224.0 COG1199@1|root,COG1199@2|Bacteria,1MVCU@1224|Proteobacteria,1RMNX@1236|Gammaproteobacteria,1X3ZE@135614|Xanthomonadales 135614|Xanthomonadales KL Helicase yoaA - 3.6.4.12 ko:K03722 - - - - ko00000,ko01000,ko03400 - - - DEAD,Helicase_C_2,ResIII k59_565992_1 863365.XHC_2104 2.1e-27 126.0 COG3209@1|root,COG3209@2|Bacteria,1MVV1@1224|Proteobacteria,1RP75@1236|Gammaproteobacteria,1X4CP@135614|Xanthomonadales 135614|Xanthomonadales M RHS Repeat - - - - - - - - - - - - RHS_repeat k59_1639298_1 342113.DM82_686 1.45e-27 114.0 COG0845@1|root,COG0845@2|Bacteria,1MW65@1224|Proteobacteria,2VHQP@28216|Betaproteobacteria,1K3XT@119060|Burkholderiaceae 28216|Betaproteobacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family mdtA - - ko:K07799 ko02020,map02020 M00648 - - ko00000,ko00001,ko00002,ko02000 8.A.1 - - Biotin_lipoyl_2,HlyD_3,HlyD_D23 k59_622280_1 1122137.AQXF01000003_gene2444 1.13e-73 226.0 COG3814@1|root,COG3814@2|Bacteria,1N1FE@1224|Proteobacteria,2U7H9@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Protein conserved in bacteria MA20_02250 - - ko:K09985 - - - - ko00000 - - - SspB k59_1243803_1 1122137.AQXF01000002_gene508 2.29e-130 384.0 COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,2TRYI@28211|Alphaproteobacteria 28211|Alphaproteobacteria C COG0277 FAD FMN-containing dehydrogenases - - - - - - - - - - - - FAD-oxidase_C,FAD_binding_4 k59_678815_1 1123392.AQWL01000001_gene1649 6.78e-88 276.0 COG0058@1|root,COG0058@2|Bacteria,1MW4J@1224|Proteobacteria,2VM4W@28216|Betaproteobacteria,1KS15@119069|Hydrogenophilales 119069|Hydrogenophilales G Carbohydrate phosphorylase - - - - - - - - - - - - Phosphorylase k59_1582796_1 1112217.PPL19_07591 1.49e-68 215.0 COG1121@1|root,COG1121@2|Bacteria,1MUDW@1224|Proteobacteria,1RPJT@1236|Gammaproteobacteria 1236|Gammaproteobacteria P Part of the ABC transporter complex ZnuABC involved in zinc import. Responsible for energy coupling to the transport system znuC GO:0000041,GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005385,GO:0005488,GO:0005524,GO:0006810,GO:0006811,GO:0006812,GO:0006829,GO:0008144,GO:0008150,GO:0008324,GO:0015075,GO:0015318,GO:0015399,GO:0015405,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022890,GO:0030001,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0043167,GO:0043168,GO:0043492,GO:0046873,GO:0046915,GO:0051179,GO:0051234,GO:0055085,GO:0070838,GO:0071577,GO:0072509,GO:0072511,GO:0097159,GO:0097367,GO:0098655,GO:0098660,GO:0098662,GO:1901265,GO:1901363 - ko:K09817 ko02010,map02010 M00242 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.15.3,3.A.1.15.5 - iSFV_1184.SFV_1859,iSF_1195.SF1867,iSFxv_1172.SFxv_2092,iS_1188.S1934 ABC_tran k59_1695682_1 1415778.JQMM01000001_gene1448 1.83e-28 120.0 COG2982@1|root,COG2982@2|Bacteria,1NVUY@1224|Proteobacteria,1RPFM@1236|Gammaproteobacteria,1J6SC@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M involved in outer membrane biogenesis asmA - - ko:K07289 - - - - ko00000 - - - AsmA k59_233268_1 279238.Saro_0213 3.22e-32 118.0 COG4149@1|root,COG4149@2|Bacteria,1MUXR@1224|Proteobacteria,2TSYJ@28211|Alphaproteobacteria,2K0AD@204457|Sphingomonadales 204457|Sphingomonadales P Molybdate modB - - ko:K02018 ko02010,map02010 M00189 - - ko00000,ko00001,ko00002,ko02000 3.A.1.8 - - BPD_transp_1 k59_233268_2 1096930.L284_20490 7.26e-51 167.0 COG4148@1|root,COG4148@2|Bacteria,1MU8K@1224|Proteobacteria,2TR1Z@28211|Alphaproteobacteria,2K1F8@204457|Sphingomonadales 204457|Sphingomonadales P ABC-type molybdate transport system, ATPase component modC - 3.6.3.29 ko:K02017 ko02010,map02010 M00189 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.8 - - ABC_tran k59_346975_1 479433.Caci_8329 1.41e-29 116.0 COG0560@1|root,COG0560@2|Bacteria,2GJW9@201174|Actinobacteria 201174|Actinobacteria E HAD-superfamily subfamily IB hydrolase, TIGR01490 serB1 GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 - - - - - - - - - - HAD k59_685182_1 566466.NOR53_23 2.08e-60 199.0 COG0475@1|root,COG0475@2|Bacteria 2|Bacteria P glutathione-regulated potassium exporter activity napA GO:0003674,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0006812,GO:0006814,GO:0008150,GO:0008324,GO:0009847,GO:0015075,GO:0015077,GO:0015081,GO:0015291,GO:0015297,GO:0015318,GO:0015672,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0022890,GO:0030001,GO:0031224,GO:0032502,GO:0034220,GO:0035725,GO:0044425,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0098655,GO:0098660,GO:0098662 - - - - - - - - - - Na_H_Exchanger k59_572187_1 270374.MELB17_21435 6.11e-106 316.0 COG0329@1|root,COG0329@2|Bacteria,1MXM5@1224|Proteobacteria 1224|Proteobacteria EM Belongs to the DapA family - - 4.3.3.7 ko:K01714 ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R10147 RC03062,RC03063 ko00000,ko00001,ko00002,ko01000 - - - DHDPS k59_685186_1 886379.AEWI01000024_gene364 1.83e-56 188.0 2DBAQ@1|root,2Z848@2|Bacteria,4NFR9@976|Bacteroidetes,2FRYW@200643|Bacteroidia,3XJ5Y@558415|Marinilabiliaceae 976|Bacteroidetes - - - - - - - - - - - - - - - k59_233282_1 319795.Dgeo_2161 5.26e-77 239.0 COG0039@1|root,COG0039@2|Bacteria,1WJHY@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus C Catalyzes the reversible oxidation of malate to oxaloacetate mdh GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006107,GO:0006108,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006734,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009060,GO:0009117,GO:0009987,GO:0015980,GO:0016491,GO:0016614,GO:0016615,GO:0016616,GO:0016999,GO:0017144,GO:0019362,GO:0019637,GO:0019674,GO:0019752,GO:0030060,GO:0034641,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044464,GO:0045333,GO:0046483,GO:0046496,GO:0051186,GO:0055086,GO:0055114,GO:0071704,GO:0072350,GO:0072524,GO:1901360,GO:1901564 1.1.1.37 ko:K00024 ko00020,ko00270,ko00620,ko00630,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00270,map00620,map00630,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740 R00342,R07136 RC00031 ko00000,ko00001,ko00002,ko01000 - - - Ldh_1_C,Ldh_1_N k59_1025136_2 1068978.AMETH_5777 6.74e-23 99.0 COG1595@1|root,COG1595@2|Bacteria,2GJ02@201174|Actinobacteria,4DXKC@85010|Pseudonocardiales 201174|Actinobacteria K Belongs to the sigma-70 factor family. ECF subfamily sigH GO:0000988,GO:0000990,GO:0003674,GO:0005575,GO:0005618,GO:0005623,GO:0006355,GO:0006950,GO:0006979,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0016987,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031326,GO:0033554,GO:0034605,GO:0043254,GO:0044087,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051252,GO:0051409,GO:0051716,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:0140110,GO:1903506,GO:2000112,GO:2000142,GO:2001141 - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 k59_515459_1 330084.JNYZ01000052_gene1486 2.08e-42 157.0 COG1884@1|root,COG1884@2|Bacteria,2GNBQ@201174|Actinobacteria,4DYG1@85010|Pseudonocardiales 201174|Actinobacteria I Methylmalonyl-CoA mutase mutA GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016999,GO:0017144,GO:0019541,GO:0019678,GO:0019752,GO:0030312,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046459,GO:0071704,GO:0071944 5.4.99.2 ko:K01847 ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200 M00373,M00376,M00741 R00833 RC00395 ko00000,ko00001,ko00002,ko01000 - - - MM_CoA_mutase k59_176856_1 316407.85676078 8e-29 103.0 COG2104@1|root,COG2104@2|Bacteria,1N6ZF@1224|Proteobacteria,1SCFT@1236|Gammaproteobacteria,3XPYX@561|Escherichia 1236|Gammaproteobacteria H thiamine biosynthesis protein ThiS thiS - - ko:K03154 ko04122,map04122 - - - ko00000,ko00001 - - iAF1260.b4407,iBWG_1329.BWG_3651,iECDH10B_1368.ECDH10B_4180,iECDH1ME8569_1439.ECDH1ME8569_3851,iECDH1ME8569_1439.EcDH1_4003,iEcDH1_1363.EcDH1_4003,iEcolC_1368.EcolC_4034,iJO1366.b4407,iJR904.b4407,iUMNK88_1353.UMNK88_4832,iY75_1357.Y75_RS17090 ThiS k59_176856_2 511145.b3991 1.98e-81 246.0 COG2022@1|root,COG2022@2|Bacteria,1N0N5@1224|Proteobacteria,1RMPD@1236|Gammaproteobacteria,3XN6M@561|Escherichia 1236|Gammaproteobacteria H Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S thiG GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.8.1.10 ko:K03149 ko00730,ko01100,map00730,map01100 - R10247 RC03096,RC03097,RC03461 ko00000,ko00001,ko01000 - - iECABU_c1320.ECABU_c45060,iECO26_1355.ECO26_5099,ic_1306.c4947 ThiG k59_64654_1 436308.Nmar_0266 5.05e-24 91.3 COG5466@1|root,arCOG05278@2157|Archaea,41T8X@651137|Thaumarchaeota 651137|Thaumarchaeota S Protein of unknown function (DUF1059) - - - - - - - - - - - - DUF1059 k59_1363590_1 506534.Rhein_3921 2.68e-28 106.0 COG0346@1|root,COG0346@2|Bacteria,1RHD4@1224|Proteobacteria,1S67S@1236|Gammaproteobacteria 1236|Gammaproteobacteria E glyoxalase bleomycin resistance protein dioxygenase - - - - - - - - - - - - Glyoxalase k59_1363590_2 857087.Metme_4272 2.29e-15 72.4 COG1734@1|root,COG1734@2|Bacteria,1N8K6@1224|Proteobacteria,1SCNZ@1236|Gammaproteobacteria,1XFHY@135618|Methylococcales 135618|Methylococcales K Prokaryotic dksA/traR C4-type zinc finger - - - - - - - - - - - - zf-dskA_traR k59_176857_1 159450.NH14_30620 2.28e-120 360.0 COG3039@1|root,COG3039@2|Bacteria,1MUVI@1224|Proteobacteria,2VZNG@28216|Betaproteobacteria,1K6IW@119060|Burkholderiaceae 28216|Betaproteobacteria L similarity to GP 3192745 - - - - - - - - - - - - DDE_Tnp_1_6,DUF772 k59_347003_1 1229909.NSED_02400 1.72e-100 296.0 COG0842@1|root,arCOG01467@2157|Archaea,41SQQ@651137|Thaumarchaeota 651137|Thaumarchaeota V PFAM ABC-2 type transporter - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane k59_1646191_1 99598.Cal7507_1651 2.91e-24 106.0 COG2274@1|root,COG2274@2|Bacteria,1FZZ2@1117|Cyanobacteria,1HJEP@1161|Nostocales 1117|Cyanobacteria V type I secretion system ABC transporter, HlyB family - - - ko:K06147 - - - - ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran,Peptidase_C39,cNMP_binding k59_120862_1 1192034.CAP_5378 1.08e-12 72.0 COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,42Q67@68525|delta/epsilon subdivisions,2WKZ1@28221|Deltaproteobacteria 1224|Proteobacteria KLT serine threonine protein kinase - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase k59_120862_2 546268.NEISUBOT_03655 1.07e-76 244.0 COG0165@1|root,COG0165@2|Bacteria,1MUTU@1224|Proteobacteria,2VH47@28216|Betaproteobacteria,2KPKI@206351|Neisseriales 206351|Neisseriales E Psort location Cytoplasmic, score 8.96 argH - 4.3.2.1 ko:K01755 ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230 M00029,M00844,M00845 R01086 RC00445,RC00447 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ASL_C2,Lyase_1 k59_7843_1 1250232.JQNJ01000001_gene1661 4.68e-25 107.0 COG1529@1|root,COG1529@2|Bacteria,4NFFU@976|Bacteroidetes,1HXJS@117743|Flavobacteriia 976|Bacteroidetes C COG1529 Aerobic-type carbon monoxide dehydrogenase large subunit CoxL CutL homologs - - 1.3.99.16 ko:K07303 - - - - ko00000,ko01000 - - - Ald_Xan_dh_C2 k59_1647170_3 1229909.NSED_03000 1.24e-21 88.6 COG1528@1|root,arCOG01095@2157|Archaea 2157|Archaea P PFAM Ferritin, Dps family protein - - 1.16.3.2 ko:K02217 - - - - ko00000,ko01000 - - - Ferritin k59_121897_1 1441930.Z042_23090 9.11e-59 202.0 COG0863@1|root,COG4725@1|root,COG0863@2|Bacteria,COG4725@2|Bacteria,1R43Z@1224|Proteobacteria,1RP5C@1236|Gammaproteobacteria,402NB@613|Serratia 1236|Gammaproteobacteria KT DNA N-6-adenine-methyltransferase (Dam) - - - - - - - - - - - - Dam k59_1138200_1 1415778.JQMM01000001_gene927 7.82e-112 340.0 COG1154@1|root,COG1154@2|Bacteria,1MUSJ@1224|Proteobacteria,1RNQD@1236|Gammaproteobacteria,1J4FF@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) dxs GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006725,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008614,GO:0008615,GO:0008654,GO:0008661,GO:0009058,GO:0009108,GO:0009110,GO:0009228,GO:0009240,GO:0009987,GO:0016740,GO:0016744,GO:0017144,GO:0018130,GO:0019288,GO:0019438,GO:0019637,GO:0019682,GO:0019752,GO:0019842,GO:0030976,GO:0032787,GO:0034641,GO:0036094,GO:0042180,GO:0042181,GO:0042364,GO:0042723,GO:0042724,GO:0042816,GO:0042819,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046490,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0071704,GO:0072524,GO:0072525,GO:0072527,GO:0072528,GO:0090407,GO:0097159,GO:1901135,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617,GO:1901661,GO:1901663,GO:1901681 2.2.1.7 ko:K01662 ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130 M00096 R05636 RC00032 ko00000,ko00001,ko00002,ko01000 - - iEcSMS35_1347.EcSMS35_0456,iJN746.PP_0527 DXP_synthase_N,Transket_pyr,Transketolase_C k59_8903_1 551789.ATVJ01000001_gene1183 7.93e-83 251.0 COG0778@1|root,COG0778@2|Bacteria,1R9VX@1224|Proteobacteria,2U5B0@28211|Alphaproteobacteria,43XGR@69657|Hyphomonadaceae 28211|Alphaproteobacteria C NADH dehydrogenase NAD(P)H nitroreductase rutE - - ko:K09019 ko00240,ko01100,map00240,map01100 - R09289 RC00087 ko00000,ko00001,ko01000 - - - Nitroreductase k59_8903_2 1122137.AQXF01000001_gene3038 6.89e-156 447.0 COG0726@1|root,COG0726@2|Bacteria,1MWR2@1224|Proteobacteria 1224|Proteobacteria G polysaccharide deacetylase yadE GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016787,GO:0016810,GO:0016814,GO:0044424,GO:0044444,GO:0044464 - - - - - - - - - - Polysacc_deac_1 k59_856378_1 702113.PP1Y_AT27402 5.97e-44 152.0 COG0649@1|root,COG0649@2|Bacteria,1MVIN@1224|Proteobacteria,2TQZ0@28211|Alphaproteobacteria,2K0QX@204457|Sphingomonadales 204457|Sphingomonadales C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoD - 1.6.5.3 ko:K00333 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_49kDa k59_856378_2 1144305.PMI02_01461 1.96e-67 210.0 COG0852@1|root,COG0852@2|Bacteria,1MX4B@1224|Proteobacteria,2TSMT@28211|Alphaproteobacteria,2K0IR@204457|Sphingomonadales 204457|Sphingomonadales C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoC - 1.6.5.3 ko:K00332 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_30kDa k59_800070_1 87626.PTD2_10914 1.42e-42 155.0 COG1629@1|root,COG4206@1|root,COG4206@2|Bacteria,COG4771@2|Bacteria,1MU9K@1224|Proteobacteria,1RMTG@1236|Gammaproteobacteria,2Q0XA@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria HP TonB dependent receptor - - - - - - - - - - - - Plug,TonB_dep_Rec k59_1026123_1 1505227.A0A076G4M1_9CAUD 3.15e-51 176.0 4QAUT@10239|Viruses,4QQ7X@28883|Caudovirales,4QIGV@10662|Myoviridae 10662|Myoviridae S DNA ligase (ATP) activity - - - - - - - - - - - - - k59_1759764_1 1088721.NSU_0945 6.75e-78 234.0 COG0094@1|root,COG0094@2|Bacteria,1MUU9@1224|Proteobacteria,2TQPF@28211|Alphaproteobacteria,2K0S5@204457|Sphingomonadales 204457|Sphingomonadales J This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits rplE - - ko:K02931 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L5,Ribosomal_L5_C k59_1759764_2 702113.PP1Y_AT17049 1.91e-60 186.0 COG0199@1|root,COG0199@2|Bacteria,1MZDT@1224|Proteobacteria,2UC01@28211|Alphaproteobacteria,2K53G@204457|Sphingomonadales 204457|Sphingomonadales J Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site rpsN - - ko:K02954 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S14 k59_800075_1 1123228.AUIH01000031_gene1679 3.47e-69 218.0 COG0673@1|root,COG0673@2|Bacteria,1MXUP@1224|Proteobacteria,1RP9K@1236|Gammaproteobacteria,1XIDD@135619|Oceanospirillales 135619|Oceanospirillales S Oxidoreductase family, NAD-binding Rossmann fold - - 1.1.1.312 ko:K10219 ko00350,ko00362,ko00627,ko01120,ko01220,map00350,map00362,map00627,map01120,map01220 M00533 R04278,R04279,R04418,R04419 RC00251,RC00254 ko00000,ko00001,ko00002,ko01000 - - - GFO_IDH_MocA,GFO_IDH_MocA_C k59_800075_2 398578.Daci_4441 5.85e-26 104.0 COG0667@1|root,COG0667@2|Bacteria,1MVEH@1224|Proteobacteria,2VH1Q@28216|Betaproteobacteria,4AA26@80864|Comamonadaceae 28216|Betaproteobacteria C aldo keto reductase - - - - - - - - - - - - Aldo_ket_red k59_1590013_1 1232683.ADIMK_2697 6.67e-16 79.3 2E8EH@1|root,332SX@2|Bacteria,1REIA@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_1590013_2 159087.Daro_2820 2.9e-23 92.8 COG2391@1|root,COG2391@2|Bacteria,1MZ3A@1224|Proteobacteria,2VSDD@28216|Betaproteobacteria,2KX6D@206389|Rhodocyclales 206389|Rhodocyclales S transporter component - - - ko:K07112 - - - - ko00000 - - - Sulf_transp k59_912596_1 314260.PB2503_02222 2.96e-88 281.0 COG0018@1|root,COG0018@2|Bacteria,1MU4J@1224|Proteobacteria,2TS3Y@28211|Alphaproteobacteria 28211|Alphaproteobacteria J Arginyl-tRNA synthetase argS - 6.1.1.19 ko:K01887 ko00970,map00970 M00359,M00360 R03646 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d k59_856404_1 247633.GP2143_14591 2.55e-50 172.0 COG1683@1|root,COG3272@1|root,COG1683@2|Bacteria,COG3272@2|Bacteria,1MXYZ@1224|Proteobacteria,1RNMF@1236|Gammaproteobacteria,1J5J0@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Protein of unknown function (DUF1722) ybgA - - - - - - - - - - - DUF1722,DUF523 k59_743067_1 640081.Dsui_2860 1.02e-107 329.0 COG0608@1|root,COG0608@2|Bacteria,1MU1M@1224|Proteobacteria,2VIGF@28216|Betaproteobacteria,2KUSS@206389|Rhodocyclales 206389|Rhodocyclales L Single-stranded-DNA-specific exonuclease RecJ recJ - - ko:K07462 ko03410,ko03430,ko03440,map03410,map03430,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DHH,DHHA1 k59_1703140_1 160799.PBOR_04275 3.45e-21 98.2 COG0747@1|root,COG0747@2|Bacteria,1TQ0N@1239|Firmicutes,4HARF@91061|Bacilli,26QIY@186822|Paenibacillaceae 91061|Bacilli E ABC transporter substrate-binding protein - - - ko:K02035 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - SBP_bac_5 k59_629858_2 13690.CP98_03708 7.41e-58 197.0 COG3723@1|root,COG3723@2|Bacteria,1R6DB@1224|Proteobacteria,2U82T@28211|Alphaproteobacteria 28211|Alphaproteobacteria L RecT family - - - ko:K07455 - - - - ko00000,ko03400 - - - RecT k59_629858_3 279238.Saro_2700 4.51e-118 348.0 COG5377@1|root,COG5377@2|Bacteria,1QCSV@1224|Proteobacteria,2UCBP@28211|Alphaproteobacteria,2K8IJ@204457|Sphingomonadales 204457|Sphingomonadales L YqaJ-like viral recombinase domain - - - - - - - - - - - - YqaJ k59_65694_1 1121921.KB898709_gene382 3.59e-22 90.5 COG5626@1|root,COG5626@2|Bacteria,1N8QB@1224|Proteobacteria,1SDJI@1236|Gammaproteobacteria,2PNZJ@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria S Protein of unknown function (DUF2288) - - - - - - - - - - - - DUF2288 k59_1364698_1 316407.85675481 8.44e-148 426.0 COG0541@1|root,COG0541@2|Bacteria,1MVIA@1224|Proteobacteria,1RMU9@1236|Gammaproteobacteria,3XNYY@561|Escherichia 1236|Gammaproteobacteria U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components ffh GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006605,GO:0006612,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0032991,GO:0033036,GO:0034613,GO:0035639,GO:0036094,GO:0042886,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0045184,GO:0046907,GO:0048500,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0070727,GO:0071702,GO:0071705,GO:0072657,GO:0090150,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1990904 3.6.5.4 ko:K03106 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko01000,ko02044 3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9 - - SRP54,SRP54_N,SRP_SPB k59_1026148_2 414684.RC1_1620 2.76e-17 81.3 COG2945@1|root,COG2945@2|Bacteria,1MUDY@1224|Proteobacteria,2TRMI@28211|Alphaproteobacteria,2JPJ6@204441|Rhodospirillales 204441|Rhodospirillales S hydrolase of the alpha beta superfamily - - - ko:K07018 - - - - ko00000 - - - Hydrolase_4,Peptidase_S15,Peptidase_S9 k59_348012_1 95619.PM1_0222295 1.54e-54 182.0 COG1028@1|root,COG1028@2|Bacteria,1R59E@1224|Proteobacteria 1224|Proteobacteria IQ KR domain - - - - - - - - - - - - adh_short_C2 k59_1759794_1 1229909.NSED_09580 1.12e-70 217.0 COG1711@1|root,arCOG00551@2157|Archaea,41SVQ@651137|Thaumarchaeota 651137|Thaumarchaeota L protein conserved in archaea - - - ko:K09723 - - - - ko00000,ko03032 - - - - k59_912617_1 765913.ThidrDRAFT_2125 1.54e-68 228.0 COG0145@1|root,COG0145@2|Bacteria,1MU2Y@1224|Proteobacteria,1RN6C@1236|Gammaproteobacteria,1WXQN@135613|Chromatiales 135613|Chromatiales EQ PFAM Hydantoinase oxoprolinase - - 3.5.2.14 ko:K01473 ko00330,ko01100,map00330,map01100 - R03187 RC00632 ko00000,ko00001,ko01000 - - - Hydant_A_N,Hydantoinase_A k59_629872_1 1122247.C731_3559 2.66e-100 309.0 COG0028@1|root,COG0028@2|Bacteria,2GM6Y@201174|Actinobacteria,234PM@1762|Mycobacteriaceae 201174|Actinobacteria EH Belongs to the TPP enzyme family - - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_65720_1 1297569.MESS2_730053 5.58e-14 75.9 COG0389@1|root,COG0389@2|Bacteria,1MUUH@1224|Proteobacteria,2TRWG@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII - - 2.7.7.7 ko:K02346 - - - - ko00000,ko01000,ko03400 - - - IMS,IMS_C k59_629880_1 224325.AF_0974 1.3e-44 161.0 COG1804@1|root,arCOG02304@2157|Archaea,2XTW7@28890|Euryarchaeota 28890|Euryarchaeota C acyl-CoA transferases carnitine dehydratase - - - - - - - - - - - - CoA_transf_3 k59_1081994_1 330214.NIDE0564 2.25e-80 246.0 COG0500@1|root,COG2226@2|Bacteria,3J0S6@40117|Nitrospirae 40117|Nitrospirae H Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) menG - 2.1.1.163,2.1.1.201 ko:K03183 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116,M00117 R04990,R04993,R06859,R08774,R09736 RC00003,RC01253,RC01662 ko00000,ko00001,ko00002,ko01000 - - - Ubie_methyltran k59_1138253_1 1379270.AUXF01000003_gene3698 2.04e-55 197.0 COG1197@1|root,COG1197@2|Bacteria,1ZT88@142182|Gemmatimonadetes 142182|Gemmatimonadetes L Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site mfd - - ko:K03723 ko03420,map03420 - - - ko00000,ko00001,ko01000,ko03400 - - - CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF k59_1647223_1 1238182.C882_1842 1.78e-66 216.0 COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2TQR1@28211|Alphaproteobacteria,2JPSC@204441|Rhodospirillales 204441|Rhodospirillales C belongs to the aldehyde dehydrogenase family gabD - 1.2.1.16,1.2.1.20,1.2.1.79 ko:K00135 ko00250,ko00310,ko00350,ko00650,ko00760,ko01100,ko01120,map00250,map00310,map00350,map00650,map00760,map01100,map01120 M00027 R00713,R00714,R02401 RC00080 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_1138259_2 76114.ebA587 3.29e-79 248.0 COG1409@1|root,COG1409@2|Bacteria,1MW6B@1224|Proteobacteria,2VHKF@28216|Betaproteobacteria,2KWHP@206389|Rhodocyclales 206389|Rhodocyclales L Calcineurin-like phosphoesterase superfamily domain - - - - - - - - - - - - Metallophos k59_968707_2 1347392.CCEZ01000014_gene2704 1.13e-32 123.0 COG0444@1|root,COG0444@2|Bacteria,1TP6E@1239|Firmicutes,247NN@186801|Clostridia,36DZS@31979|Clostridiaceae 186801|Clostridia P Belongs to the ABC transporter superfamily - - - ko:K15583 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00439 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 - - ABC_tran,oligo_HPY k59_1026173_1 1283300.ATXB01000001_gene1162 6.49e-144 449.0 COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1145@1|root,COG1146@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1145@2|Bacteria,COG1146@2|Bacteria,1MVM0@1224|Proteobacteria,1RNNX@1236|Gammaproteobacteria,1XE3B@135618|Methylococcales 135618|Methylococcales C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin - - 1.2.7.1 ko:K03737 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00173,M00307 R01196,R10866 RC00004,RC02742 br01601,ko00000,ko00001,ko00002,ko01000 - - - EKR,Fer4_16,PFOR_II,POR,POR_N,TPP_enzyme_C k59_1420574_1 318167.Sfri_2069 1.28e-91 279.0 COG1960@1|root,COG1960@2|Bacteria,1MU2V@1224|Proteobacteria,1RNJH@1236|Gammaproteobacteria,2QDIN@267890|Shewanellaceae 1236|Gammaproteobacteria C Acyl-CoA dehydrogenase, type 2, C-terminal - - 1.3.8.7 ko:K00249 ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320 M00013,M00036,M00087 R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754 RC00052,RC00068,RC00076,RC00095,RC00148,RC00246 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_800122_1 502025.Hoch_6464 4.78e-155 440.0 COG0447@1|root,COG0447@2|Bacteria,1QTZ2@1224|Proteobacteria,42MZ7@68525|delta/epsilon subdivisions,2WKXM@28221|Deltaproteobacteria,2YU3B@29|Myxococcales 28221|Deltaproteobacteria H Belongs to the enoyl-CoA hydratase isomerase family. MenB subfamily menB - 4.1.3.36 ko:K01661 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116 R07263 RC01923 ko00000,ko00001,ko00002,ko01000 - - - ECH_1 k59_1251568_1 391625.PPSIR1_16130 2.02e-68 224.0 COG3039@1|root,COG3039@2|Bacteria,1R70H@1224|Proteobacteria,42Y58@68525|delta/epsilon subdivisions,2WTVD@28221|Deltaproteobacteria 28221|Deltaproteobacteria L Transposase domain (DUF772) - - - ko:K07487 - - - - ko00000 - - - DDE_Tnp_1,DUF772 k59_686328_1 1269813.ATUL01000008_gene1515 2.62e-73 231.0 COG0649@1|root,COG0649@2|Bacteria,1MVIN@1224|Proteobacteria,1RM98@1236|Gammaproteobacteria,1WWN5@135613|Chromatiales 135613|Chromatiales C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoD - 1.6.5.3 ko:K00333 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_49kDa k59_686328_2 1122164.JHWF01000016_gene1555 2.43e-17 78.6 COG1905@1|root,COG1905@2|Bacteria,1MWS2@1224|Proteobacteria,1RN4C@1236|Gammaproteobacteria,1JCT5@118969|Legionellales 118969|Legionellales C Thioredoxin-like [2Fe-2S] ferredoxin nuoE - 1.6.5.3 ko:K00334 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - 2Fe-2S_thioredx k59_686333_1 387631.Asulf_00750 9.91e-08 61.2 COG2202@1|root,arCOG02387@1|root,arCOG02387@2157|Archaea,arCOG06538@2157|Archaea,2Y14Z@28890|Euryarchaeota,2473B@183980|Archaeoglobi 28890|Euryarchaeota T PAS domain - - - - - - - - - - - - PAS,PAS_9 k59_1026196_1 690850.Desaf_2867 9.72e-26 100.0 COG3324@1|root,COG3324@2|Bacteria,1PV0A@1224|Proteobacteria,4367N@68525|delta/epsilon subdivisions,2X9GI@28221|Deltaproteobacteria,2MD8H@213115|Desulfovibrionales 28221|Deltaproteobacteria S Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - ko:K06996 - - - - ko00000 - - - Glyoxalase k59_9032_1 469371.Tbis_2156 1.74e-77 257.0 COG0022@1|root,COG1071@1|root,COG0022@2|Bacteria,COG1071@2|Bacteria,2GNII@201174|Actinobacteria,4DYAF@85010|Pseudonocardiales 201174|Actinobacteria C Transketolase, pyrimidine binding domain - - 1.2.4.4 ko:K11381 ko00280,ko00640,ko01100,ko01110,ko01130,map00280,map00640,map01100,map01110,map01130 M00036 R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997 RC00027,RC00627,RC02743,RC02883,RC02949,RC02953 br01601,ko00000,ko00001,ko00002,ko01000 - - - E1_dh,Transket_pyr,Transketolase_C k59_291643_1 498211.CJA_0150 2.97e-107 315.0 COG0745@1|root,COG0745@2|Bacteria,1MY2Z@1224|Proteobacteria,1RN41@1236|Gammaproteobacteria,1FFRQ@10|Cellvibrio 1236|Gammaproteobacteria K Transcriptional regulatory protein, C terminal phoB GO:0001098,GO:0001108,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0042802,GO:0043254,GO:0044087,GO:0044424,GO:0044464,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:1903506,GO:2000112,GO:2000142,GO:2001141 - ko:K07657 ko02020,map02020 M00434 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Trans_reg_C k59_912653_1 859657.RPSI07_3066 6.15e-27 110.0 COG0004@1|root,COG0004@2|Bacteria,1NR9F@1224|Proteobacteria,2VJ8B@28216|Betaproteobacteria,1K0BN@119060|Burkholderiaceae 28216|Betaproteobacteria P Ammonium transporter amtB - - ko:K03320 - - - - ko00000,ko02000 1.A.11 - - Ammonium_transp k59_912653_2 272568.GDI0707 1.88e-44 147.0 COG0347@1|root,COG0347@2|Bacteria,1RGWK@1224|Proteobacteria,2U952@28211|Alphaproteobacteria,2JSPI@204441|Rhodospirillales 204441|Rhodospirillales K Belongs to the P(II) protein family - - - ko:K04752 - - - - ko00000 - - - P-II k59_9037_1 1120953.AUBH01000001_gene741 3.86e-201 574.0 COG0480@1|root,COG0480@2|Bacteria,1MUCV@1224|Proteobacteria,1RNNJ@1236|Gammaproteobacteria,464WS@72275|Alteromonadaceae 1236|Gammaproteobacteria J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome fusA2 GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2 k59_298125_1 160799.PBOR_21250 1.4e-13 71.6 COG0618@1|root,COG0618@2|Bacteria,1TPXX@1239|Firmicutes,4H9ZW@91061|Bacilli,26S55@186822|Paenibacillaceae 91061|Bacilli S DHH family nrnA - 3.1.13.3,3.1.3.7 ko:K06881 ko00920,ko01100,ko01120,map00920,map01100,map01120 - R00188,R00508 RC00078 ko00000,ko00001,ko01000,ko03400 - - - DHH,DHHA1 k59_298125_2 266117.Rxyl_1415 8.03e-41 145.0 COG0130@1|root,COG0130@2|Bacteria,2GJZK@201174|Actinobacteria,4CPY4@84995|Rubrobacteria 84995|Rubrobacteria J Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs truB - 5.4.99.25 ko:K03177 - - - - ko00000,ko01000,ko03016 - - - TruB-C_2,TruB_N k59_1709680_1 161528.ED21_23756 1.58e-82 262.0 COG0484@1|root,COG0484@2|Bacteria,1MXM9@1224|Proteobacteria,2U31V@28211|Alphaproteobacteria,2K3PY@204457|Sphingomonadales 204457|Sphingomonadales O heat shock protein binding - - - - - - - - - - - - - k59_1653727_1 83406.HDN1F_06470 3.72e-85 263.0 COG2046@1|root,COG2046@2|Bacteria,1MUQB@1224|Proteobacteria,1RP4Q@1236|Gammaproteobacteria,1J8M1@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria F Sulfate adenylate transferase sat - 2.7.7.4 ko:K00958 ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130 M00176,M00596 R00529,R04929 RC02809,RC02889 ko00000,ko00001,ko00002,ko01000 - - - ATP-sulfurylase,PUA_2 k59_466658_1 744872.Spica_0030 1.59e-24 100.0 COG2816@1|root,COG2816@2|Bacteria,2JBJ3@203691|Spirochaetes 203691|Spirochaetes L NUDIX domain - - - - - - - - - - - - NUDIX k59_184767_1 264462.Bd3189 2.17e-77 249.0 COG0206@1|root,COG0206@2|Bacteria,1MV2X@1224|Proteobacteria,42MHK@68525|delta/epsilon subdivisions,2MSTJ@213481|Bdellovibrionales,2WJAZ@28221|Deltaproteobacteria 213481|Bdellovibrionales D Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity ftsZ - - ko:K03531 ko04112,map04112 - - - ko00000,ko00001,ko02048,ko03036,ko04812 - - - FtsZ_C,Tubulin k59_749095_1 1123279.ATUS01000001_gene1000 4.15e-39 141.0 COG1024@1|root,COG1024@2|Bacteria,1MXZ2@1224|Proteobacteria,1S4UD@1236|Gammaproteobacteria,1J9HV@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria I Enoyl-CoA hydratase/isomerase - - 5.3.3.18 ko:K15866 ko00360,ko01120,map00360,map01120 - R09837,R09839 RC00004,RC00326,RC02689,RC03003 ko00000,ko00001,ko01000 - - - ECH_1 k59_974533_1 1174684.EBMC1_14530 5.24e-12 66.2 COG0065@1|root,COG0065@2|Bacteria,1MVYR@1224|Proteobacteria,2TR6K@28211|Alphaproteobacteria,2K0IM@204457|Sphingomonadales 204457|Sphingomonadales E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate - - - - - - - - - - - - Aconitase k59_974533_2 1121106.JQKB01000020_gene1981 2.54e-52 178.0 COG1893@1|root,COG1893@2|Bacteria,1MVZ1@1224|Proteobacteria,2TRJN@28211|Alphaproteobacteria,2JV65@204441|Rhodospirillales 204441|Rhodospirillales H Ketopantoate reductase PanE/ApbA C terminal - - - - - - - - - - - - ApbA,ApbA_C k59_1426983_1 1117647.M5M_08040 1.43e-37 132.0 COG5126@1|root,COG5126@2|Bacteria,1N311@1224|Proteobacteria,1S9K9@1236|Gammaproteobacteria 1236|Gammaproteobacteria DTZ EF hand - - - - - - - - - - - - EF-hand_5 k59_1426983_2 1168065.DOK_13794 1.15e-14 72.4 COG0540@1|root,COG0540@2|Bacteria,1MWAB@1224|Proteobacteria,1RPSV@1236|Gammaproteobacteria,1J4H1@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria F Belongs to the ATCase OTCase family pyrB GO:0003674,GO:0003824,GO:0004070,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016741,GO:0016743,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.3.2 ko:K00609 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R01397 RC00064,RC02850 ko00000,ko00001,ko00002,ko01000 - - iZ_1308.Z5856 OTCace,OTCace_N k59_466659_1 1380600.AUYN01000002_gene2 8.16e-07 57.0 COG3291@1|root,COG3291@2|Bacteria,4NDZQ@976|Bacteroidetes,1HX5A@117743|Flavobacteriia 976|Bacteroidetes M C-terminal domain of CHU protein family - - - - - - - - - - - - CHU_C,HYR,PKD,SprB k59_72331_1 1123072.AUDH01000041_gene1352 8.33e-17 86.7 COG1196@1|root,COG1196@2|Bacteria,1R2C4@1224|Proteobacteria 1224|Proteobacteria D Protein of unknown function (DUF563) - - - - - - - - - - - - DUF563 k59_1201525_1 1229909.NSED_05610 8.37e-07 52.0 arCOG08728@1|root,arCOG08728@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_579831_2 543728.Vapar_4891 1.07e-46 159.0 COG0745@1|root,COG0745@2|Bacteria,1MY3D@1224|Proteobacteria,2VIYR@28216|Betaproteobacteria,4ACV9@80864|Comamonadaceae 28216|Betaproteobacteria K Two component transcriptional regulator - - - ko:K11329 ko02020,map02020 M00467 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Trans_reg_C k59_1766278_1 1056820.KB900674_gene2664 2.54e-12 67.8 COG3866@1|root,COG3866@2|Bacteria,1QPFF@1224|Proteobacteria,1RQEM@1236|Gammaproteobacteria,2PMMI@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria G Amb_all - - - - - - - - - - - - CBM_35,CBM_5_12_2,CBM_6,Pec_lyase_C,RicinB_lectin_2 k59_692796_1 411483.FAEPRAA2165_03089 2.85e-83 269.0 COG3459@1|root,COG3459@2|Bacteria,1TQY8@1239|Firmicutes,248YP@186801|Clostridia,3WGK9@541000|Ruminococcaceae 186801|Clostridia G Glycosyltransferase family 36 - - 2.4.1.20 ko:K00702 ko00500,ko01100,map00500,map01100 - R00952 RC00049 ko00000,ko00001,ko01000 - GT36 - Glyco_hydro_36,Glyco_transf_36 k59_1653765_1 580332.Slit_1793 5.46e-64 215.0 COG1138@1|root,COG1138@2|Bacteria,1MUQS@1224|Proteobacteria,2VHUE@28216|Betaproteobacteria,44VEM@713636|Nitrosomonadales 28216|Betaproteobacteria O TIGRFAM cytochrome c-type biogenesis protein CcmF ccmF - - ko:K02198 - - - - ko00000,ko02000 9.B.14.1 - - CcmF_C,Cytochrom_C_asm k59_1653765_2 243233.MCA0417 1.17e-51 168.0 COG0526@1|root,COG0526@2|Bacteria,1RI3N@1224|Proteobacteria,1S5YV@1236|Gammaproteobacteria,1XF10@135618|Methylococcales 135618|Methylococcales CO TIGRFAM periplasmic protein thiol - - - ko:K02199 - - - - ko00000,ko03110 - - - Redoxin k59_1371410_1 1178825.ALIH01000003_gene2027 1.02e-78 240.0 COG2197@1|root,COG2197@2|Bacteria,4NN0B@976|Bacteroidetes,1I0A6@117743|Flavobacteriia 976|Bacteroidetes T COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain - - - - - - - - - - - - GerE,Response_reg k59_692799_1 928724.SacglDRAFT_02959 2.97e-05 52.4 COG3063@1|root,COG3088@1|root,COG3063@2|Bacteria,COG3088@2|Bacteria,2I5EC@201174|Actinobacteria,4EBQB@85010|Pseudonocardiales 201174|Actinobacteria NU subunit of a heme lyase - - - - - - - - - - - - - k59_749134_1 935567.JAES01000029_gene2752 1.46e-28 112.0 COG1073@1|root,COG1073@2|Bacteria,1R34U@1224|Proteobacteria,1SYR4@1236|Gammaproteobacteria,1X4S6@135614|Xanthomonadales 135614|Xanthomonadales S alpha beta - - - ko:K06889 - - - - ko00000 - - - - k59_863392_1 697282.Mettu_0353 1.26e-36 130.0 COG1704@1|root,COG1704@2|Bacteria,1MVH0@1224|Proteobacteria,1RP1N@1236|Gammaproteobacteria 1236|Gammaproteobacteria S LemA family lemA - - ko:K03744 - - - - ko00000 - - - LemA k59_579844_1 1054213.HMPREF9946_01130 4.29e-27 110.0 COG2936@1|root,COG2936@2|Bacteria,1MVA8@1224|Proteobacteria,2TU0R@28211|Alphaproteobacteria,2JV41@204441|Rhodospirillales 204441|Rhodospirillales S X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain - - - - - - - - - - - - PepX_C,Peptidase_S15 k59_579844_2 493475.GARC_1658 1.43e-104 320.0 COG1288@1|root,COG1288@2|Bacteria,1MY1J@1224|Proteobacteria,1RS2M@1236|Gammaproteobacteria,46ACE@72275|Alteromonadaceae 1236|Gammaproteobacteria S C4-dicarboxylate anaerobic carrier - - - - - - - - - - - - DcuC k59_522782_2 1500306.JQLA01000029_gene188 2.86e-27 111.0 COG0415@1|root,COG0415@2|Bacteria,1MV9Y@1224|Proteobacteria,2TSDP@28211|Alphaproteobacteria,4B91H@82115|Rhizobiaceae 28211|Alphaproteobacteria L Belongs to the DNA photolyase family phrB GO:0000003,GO:0000166,GO:0000719,GO:0001101,GO:0002252,GO:0002376,GO:0003006,GO:0003674,GO:0003824,GO:0003904,GO:0003913,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005773,GO:0006139,GO:0006259,GO:0006281,GO:0006290,GO:0006325,GO:0006338,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006873,GO:0006874,GO:0006875,GO:0006950,GO:0006952,GO:0006974,GO:0006996,GO:0007154,GO:0007165,GO:0007275,GO:0007623,GO:0008144,GO:0008150,GO:0008152,GO:0009117,GO:0009314,GO:0009414,GO:0009415,GO:0009416,GO:0009605,GO:0009606,GO:0009607,GO:0009615,GO:0009628,GO:0009637,GO:0009638,GO:0009642,GO:0009645,GO:0009646,GO:0009648,GO:0009719,GO:0009725,GO:0009785,GO:0009791,GO:0009881,GO:0009882,GO:0009888,GO:0009893,GO:0009909,GO:0009911,GO:0009987,GO:0010033,GO:0010035,GO:0010073,GO:0010075,GO:0010118,GO:0010228,GO:0010244,GO:0010617,GO:0014070,GO:0016043,GO:0016604,GO:0016829,GO:0016830,GO:0017076,GO:0019222,GO:0019637,GO:0019725,GO:0022414,GO:0022603,GO:0023052,GO:0030003,GO:0030522,GO:0030554,GO:0031323,GO:0031325,GO:0031974,GO:0031981,GO:0032501,GO:0032502,GO:0032553,GO:0032555,GO:0032559,GO:0033554,GO:0033993,GO:0034641,GO:0035639,GO:0036094,GO:0038023,GO:0040008,GO:0042221,GO:0042592,GO:0042726,GO:0042752,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0043207,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0044237,GO:0044238,GO:0044260,GO:0044281,GO:0044422,GO:0044424,GO:0044428,GO:0044444,GO:0044446,GO:0044451,GO:0044464,GO:0046483,GO:0048037,GO:0048507,GO:0048509,GO:0048511,GO:0048518,GO:0048522,GO:0048571,GO:0048573,GO:0048574,GO:0048580,GO:0048582,GO:0048583,GO:0048608,GO:0048638,GO:0048731,GO:0048831,GO:0048856,GO:0048878,GO:0050660,GO:0050662,GO:0050789,GO:0050793,GO:0050794,GO:0050801,GO:0050896,GO:0051094,GO:0051186,GO:0051239,GO:0051240,GO:0051276,GO:0051480,GO:0051607,GO:0051704,GO:0051707,GO:0051716,GO:0055065,GO:0055074,GO:0055080,GO:0055082,GO:0055086,GO:0060089,GO:0061458,GO:0065007,GO:0065008,GO:0070013,GO:0071214,GO:0071478,GO:0071482,GO:0071483,GO:0071704,GO:0071840,GO:0071949,GO:0072387,GO:0072503,GO:0072507,GO:0090304,GO:0097159,GO:0097367,GO:0098542,GO:0098771,GO:0104004,GO:0140097,GO:1900618,GO:1901265,GO:1901360,GO:1901363,GO:1901371,GO:1901564,GO:1901700,GO:1902347,GO:1905421,GO:2000024,GO:2000026,GO:2000028,GO:2000241,GO:2000243,GO:2000377,GO:2000379 4.1.99.3 ko:K01669 - - - - ko00000,ko01000,ko03400 - - - DNA_photolyase,FAD_binding_7 k59_636364_1 396595.TK90_1971 3.93e-62 202.0 COG0797@1|root,COG3087@1|root,COG0797@2|Bacteria,COG3087@2|Bacteria,1MZ8S@1224|Proteobacteria,1RMCG@1236|Gammaproteobacteria,1WW9X@135613|Chromatiales 135613|Chromatiales M Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides rlpA - - ko:K03642 - - - - ko00000 - - - DPBB_1,SPOR k59_1032728_1 1231391.AMZF01000074_gene1297 3.24e-69 234.0 COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,2VI87@28216|Betaproteobacteria,3T1BB@506|Alcaligenaceae 28216|Betaproteobacteria L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate uvrA2 - - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - ABC_tran k59_15229_1 909663.KI867150_gene2882 1.4e-23 99.8 COG0493@1|root,COG0543@1|root,COG0493@2|Bacteria,COG0543@2|Bacteria,1MU2H@1224|Proteobacteria,42MGY@68525|delta/epsilon subdivisions,2WJHC@28221|Deltaproteobacteria,2MREN@213462|Syntrophobacterales 28221|Deltaproteobacteria C TIGRFAM glutamate synthase (NADPH), homotetrameric nfnA - 1.4.1.13,1.4.1.14 ko:K00266 ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 - R00093,R00114,R00248 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - DHODB_Fe-S_bind,Fer4_20,Pyr_redox_2 k59_1201550_1 1122137.AQXF01000002_gene500 3.26e-113 337.0 COG2265@1|root,COG2265@2|Bacteria,1MV3A@1224|Proteobacteria,2TR40@28211|Alphaproteobacteria 28211|Alphaproteobacteria J Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family rumA - 2.1.1.190,2.1.1.35 ko:K00557,ko:K03215 - - - - ko00000,ko01000,ko03009,ko03016 - - - tRNA_U5-meth_tr k59_1201550_2 375286.mma_3323 1.03e-15 81.6 COG3713@1|root,COG3713@2|Bacteria,1MWQN@1224|Proteobacteria,2VX3J@28216|Betaproteobacteria,4790A@75682|Oxalobacteraceae 28216|Betaproteobacteria M MltA-interacting protein MipA - - - ko:K07274 - - - - ko00000,ko02000 9.B.99.1 - - MipA k59_410337_1 1459636.NTE_02516 2.31e-16 75.9 COG1714@1|root,arCOG03633@2157|Archaea,41T5P@651137|Thaumarchaeota 651137|Thaumarchaeota S membrane protein domain - - - - - - - - - - - - RDD k59_410337_2 1459636.NTE_01238 8.26e-12 62.0 COG1522@1|root,arCOG01117@2157|Archaea 1459636.NTE_01238|- K COG1522 Transcriptional regulators - - - - - - - - - - - - - k59_1709748_1 1121374.KB891589_gene94 5.44e-63 211.0 COG0477@1|root,COG2814@2|Bacteria,1QKNX@1224|Proteobacteria,1RSAI@1236|Gammaproteobacteria 1236|Gammaproteobacteria EGP Major Facilitator - - - - - - - - - - - - MFS_1 k59_72382_1 887898.HMPREF0551_1238 3.68e-15 78.6 COG1187@1|root,COG1187@2|Bacteria,1MUCE@1224|Proteobacteria,2VITB@28216|Betaproteobacteria,1K0N5@119060|Burkholderiaceae 28216|Betaproteobacteria J Belongs to the pseudouridine synthase RsuA family rluB - 5.4.99.22 ko:K06178 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2,S4 k59_72382_2 454957.IA64_11700 1.55e-18 87.0 COG0128@1|root,COG0128@2|Bacteria,1MWMK@1224|Proteobacteria,1RQ8U@1236|Gammaproteobacteria,1X36A@135614|Xanthomonadales 135614|Xanthomonadales E Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate aroA GO:0003674,GO:0003824,GO:0003866,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046417,GO:0071704,GO:1901576 2.5.1.19 ko:K00800 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R03460 RC00350 ko00000,ko00001,ko00002,ko01000 - - - EPSP_synthase k59_15239_1 1122137.AQXF01000001_gene3281 4.16e-64 205.0 COG1466@1|root,COG1466@2|Bacteria,1R8PA@1224|Proteobacteria,2U1KQ@28211|Alphaproteobacteria 28211|Alphaproteobacteria L DNA polymerase III delta subunit holA - 2.7.7.7 ko:K02340 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_delta k59_1427033_1 1469557.JSWF01000027_gene1928 5.7e-12 64.3 COG1555@1|root,COG1555@2|Bacteria,4NK4K@976|Bacteroidetes,1HX4K@117743|Flavobacteriia 976|Bacteroidetes L COG1555 DNA uptake protein and related DNA-binding comEA - - - - - - - - - - - HHH_3 k59_1427033_2 1121912.AUHD01000001_gene2415 1.17e-77 241.0 COG1960@1|root,COG1960@2|Bacteria,4NFD4@976|Bacteroidetes,1HWQD@117743|Flavobacteriia 976|Bacteroidetes I acyl-CoA dehydrogenase - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_749161_1 391603.FBALC1_13827 6.12e-132 382.0 COG3064@1|root,COG3064@2|Bacteria,4NEVD@976|Bacteroidetes,1HXMP@117743|Flavobacteriia 976|Bacteroidetes M membrane - - - - - - - - - - - - PorP_SprF k59_410353_1 1123518.ARWI01000001_gene1639 1.89e-07 57.4 COG2132@1|root,COG2132@2|Bacteria,1PM6Q@1224|Proteobacteria,1RRZJ@1236|Gammaproteobacteria 1236|Gammaproteobacteria Q Parallel beta-helix repeats - - - - - - - - - - - - Cu-oxidase_3 k59_1257673_1 1100720.ALKN01000040_gene2175 5.17e-66 214.0 COG2873@1|root,COG2873@2|Bacteria,1NQME@1224|Proteobacteria,2VHYA@28216|Betaproteobacteria,4AACZ@80864|Comamonadaceae 28216|Betaproteobacteria E TIGRFAM O-acetylhomoserine O-acetylserine sulfhydrylase - - 2.5.1.49 ko:K01740 ko00270,ko01100,map00270,map01100 - R01287,R04859 RC00020,RC02821,RC02848 ko00000,ko00001,ko01000 - - - Cys_Met_Meta_PP k59_354694_1 1415778.JQMM01000001_gene978 6.25e-78 252.0 COG0497@1|root,COG0497@2|Bacteria,1MUNP@1224|Proteobacteria,1RNPZ@1236|Gammaproteobacteria,1J5DR@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L May be involved in recombinational repair of damaged DNA recN GO:0000724,GO:0000725,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009314,GO:0009432,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0090304,GO:1901360 - ko:K03631 - - - - ko00000,ko03400 - - - AAA_23,SMC_N k59_1032765_1 929794.CALV01000016_gene131 3.26e-81 257.0 COG1384@1|root,COG1384@2|Bacteria,1MV32@1224|Proteobacteria,2TQYH@28211|Alphaproteobacteria,48T8Q@772|Bartonellaceae 28211|Alphaproteobacteria J Belongs to the class-I aminoacyl-tRNA synthetase family lysS - 6.1.1.6 ko:K04566 ko00970,map00970 M00360 R03658 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_1f k59_466708_1 1122970.AUHC01000004_gene2316 3.38e-106 330.0 COG1472@1|root,COG1472@2|Bacteria,1MVIV@1224|Proteobacteria,2TS28@28211|Alphaproteobacteria,2JZVY@204457|Sphingomonadales 204457|Sphingomonadales G Belongs to the glycosyl hydrolase 3 family - - 3.2.1.21 ko:K05349 ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110 - R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040 RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248 ko00000,ko00001,ko01000 - GH3 - Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C k59_1088342_1 1499686.BN1079_00332 2.78e-78 244.0 COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,1RM93@1236|Gammaproteobacteria 1236|Gammaproteobacteria I Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed fadA GO:0003674,GO:0003824,GO:0003988,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016408,GO:0016740,GO:0016746,GO:0016747,GO:0019395,GO:0019752,GO:0030258,GO:0032787,GO:0034440,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044424,GO:0044464,GO:0046395,GO:0055114,GO:0071704,GO:0072329,GO:1901575 2.3.1.16 ko:K00632 ko00071,ko00280,ko00281,ko00362,ko00592,ko00642,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00362,map00592,map00642,map01100,map01110,map01120,map01130,map01212 M00087,M00113 R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095 RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955 ko00000,ko00001,ko00002,ko01000 - - iAPECO1_1312.APECO1_2612,iECNA114_1301.ECNA114_4154,iECOK1_1307.ECOK1_4314,iECP_1309.ECP_4058,iECS88_1305.ECS88_4293,iECSF_1327.ECSF_3702,iEcE24377_1341.EcE24377A_4364,iLF82_1304.LF82_0613,iNRG857_1313.NRG857_19195,iPC815.YPO3767 Thiolase_C,Thiolase_N k59_1427039_1 1147137.I1TJZ3_9CAUD 3.85e-13 80.5 4QAKZ@10239|Viruses,4QYAE@35237|dsDNA viruses no RNA stage,4QPYH@28883|Caudovirales,4QM57@10699|Siphoviridae 10699|Siphoviridae S intein-mediated protein splicing - - - - - - - - - - - - - k59_749172_1 1144305.PMI02_01301 4.64e-185 543.0 COG1752@1|root,COG1752@2|Bacteria,1MWH2@1224|Proteobacteria,2TU16@28211|Alphaproteobacteria,2K0ET@204457|Sphingomonadales 204457|Sphingomonadales S Protein of unknown function (DUF3376) - - - - - - - - - - - - DUF3376,Patatin k59_749172_2 158500.BV97_00770 2.07e-09 57.0 COG0484@1|root,COG0484@2|Bacteria,1MVMS@1224|Proteobacteria,2TRZ1@28211|Alphaproteobacteria,2K1EY@204457|Sphingomonadales 204457|Sphingomonadales O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins dnaJ - - ko:K03686 - - - - ko00000,ko03029,ko03110 - - - DnaJ,DnaJ_C,DnaJ_CXXCXGXG k59_1201583_1 1144275.COCOR_07754 1.42e-37 145.0 COG4232@1|root,COG4233@1|root,COG4232@2|Bacteria,COG4233@2|Bacteria,1MU8W@1224|Proteobacteria,42MVQ@68525|delta/epsilon subdivisions,2WKBG@28221|Deltaproteobacteria,2YYAD@29|Myxococcales 28221|Deltaproteobacteria CO Disulphide bond corrector protein DsbC dsbD - 1.8.1.8 ko:K04084 - - - - ko00000,ko01000,ko03110 5.A.1.1 - - DsbC,DsbD,Thioredoxin,Thioredoxin_7 k59_1201583_2 1173027.Mic7113_6375 5.05e-51 171.0 COG1225@1|root,COG1225@2|Bacteria,1G7FA@1117|Cyanobacteria,1HFB0@1150|Oscillatoriales 1117|Cyanobacteria O Redoxin - - - - - - - - - - - - AhpC-TSA k59_72411_1 1123008.KB905692_gene276 3.36e-41 149.0 COG3203@1|root,COG3203@2|Bacteria,4NHHZ@976|Bacteroidetes 976|Bacteroidetes M Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane - - - - - - - - - - - - Porin_4 k59_1653821_1 1443111.JASG01000004_gene611 8.68e-69 225.0 COG4962@1|root,COG4962@2|Bacteria,1R7EN@1224|Proteobacteria,2TRNT@28211|Alphaproteobacteria,3ZVJ3@60136|Sulfitobacter 28211|Alphaproteobacteria U Type II/IV secretion system protein cpaF - - ko:K02283 - - - - ko00000,ko02035,ko02044 - - - T2SSE k59_863430_1 1238182.C882_0320 3.3e-39 139.0 COG1126@1|root,COG1126@2|Bacteria,1MWKQ@1224|Proteobacteria,2TSCU@28211|Alphaproteobacteria,2JRVW@204441|Rhodospirillales 204441|Rhodospirillales E ABC transporter - - - - - - - - - - - - ABC_tran k59_863430_2 384765.SIAM614_22527 1.5e-07 53.9 COG2998@1|root,COG2998@2|Bacteria,1MVSF@1224|Proteobacteria,2TU33@28211|Alphaproteobacteria 28211|Alphaproteobacteria H COG2998 ABC-type tungstate transport system, permease component tupA - - ko:K05772 ko02010,map02010 M00186 - - ko00000,ko00001,ko00002,ko02000 3.A.1.6.2,3.A.1.6.4 - - PBP_like_2 k59_72414_1 702113.PP1Y_AT24676 3.7e-147 430.0 COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,2TR1I@28211|Alphaproteobacteria,2K0GG@204457|Sphingomonadales 204457|Sphingomonadales EH COG0028 Thiamine pyrophosphate-requiring enzymes acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase ilvB - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_354719_1 1027292.HMPREF9372_1559 6.5e-13 74.3 COG1960@1|root,COG1960@2|Bacteria,1TQC8@1239|Firmicutes,4HC6Y@91061|Bacilli,26EEQ@186818|Planococcaceae 91061|Bacilli I Acyl-CoA dehydrogenase, C-terminal domain - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M k59_72417_1 1541065.JRFE01000047_gene3309 2.36e-68 224.0 COG2837@1|root,COG2837@2|Bacteria,1G5Q6@1117|Cyanobacteria 1117|Cyanobacteria P TIGRFAM Dyp-type peroxidase family - - - - - - - - - - - - Dyp_perox k59_1484685_1 5180.EDO03703 2.92e-19 88.6 COG1132@1|root,KOG0055@2759|Eukaryota,39F0C@33154|Opisthokonta,3NX6D@4751|Fungi,3QRFA@4890|Ascomycota 4751|Fungi Q multidrug - - - - - - - - - - - - ABC_membrane,ABC_tran k59_1371493_1 192952.MM_1316 5.24e-30 120.0 COG0591@1|root,arCOG01316@2157|Archaea,2XU91@28890|Euryarchaeota,2NA72@224756|Methanomicrobia 224756|Methanomicrobia E Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family - - - ko:K11928 - - - - ko00000,ko02000 2.A.21.2 - - SSF k59_918901_1 1255043.TVNIR_2636 7.35e-44 154.0 COG0530@1|root,COG0530@2|Bacteria,1MU3R@1224|Proteobacteria,1RMRD@1236|Gammaproteobacteria,1WXKK@135613|Chromatiales 135613|Chromatiales P Sodium/calcium exchanger protein - - - ko:K07301 - - - - ko00000,ko02000 2.A.19.5 - - Na_Ca_ex k59_15276_1 502025.Hoch_5377 1.44e-86 276.0 COG0326@1|root,COG0326@2|Bacteria,1MUUE@1224|Proteobacteria,42N42@68525|delta/epsilon subdivisions,2WK62@28221|Deltaproteobacteria,2YWZ7@29|Myxococcales 28221|Deltaproteobacteria O Molecular chaperone. Has ATPase activity htpG - - ko:K04079 ko04141,ko04151,ko04217,ko04612,ko04621,ko04626,ko04657,ko04659,ko04914,ko04915,ko05200,ko05215,ko05418,map04141,map04151,map04217,map04612,map04621,map04626,map04657,map04659,map04914,map04915,map05200,map05215,map05418 - - - ko00000,ko00001,ko01009,ko03029,ko03051,ko03110,ko04131,ko04147 - - - HATPase_c,HATPase_c_3,HSP90 k59_1088387_1 1349820.M707_07340 4.73e-30 116.0 COG2189@1|root,COG2189@2|Bacteria,2I8FH@201174|Actinobacteria,1W812@1268|Micrococcaceae 201174|Actinobacteria L Belongs to the N(4) N(6)-methyltransferase family - - 2.1.1.72 ko:K00571 - - - - ko00000,ko01000,ko02048 - - - N6_N4_Mtase k59_1201628_1 400668.Mmwyl1_0171 4.76e-57 187.0 COG0491@1|root,COG0491@2|Bacteria,1R4FA@1224|Proteobacteria,1S1QD@1236|Gammaproteobacteria,1XMJP@135619|Oceanospirillales 135619|Oceanospirillales S Metallo-beta-lactamase superfamily - - - - - - - - - - - - Lactamase_B k59_1653858_1 667632.KB890176_gene4405 2.23e-15 77.4 COG2010@1|root,COG2010@2|Bacteria,1MV6D@1224|Proteobacteria,2WHBT@28216|Betaproteobacteria,1K0BU@119060|Burkholderiaceae 28216|Betaproteobacteria C Cytochrome c class I - - - - - - - - - - - - Cytochrom_C,Cytochrome_CBB3 k59_298279_1 247633.GP2143_01710 2.67e-26 110.0 COG2211@1|root,COG2211@2|Bacteria,1MVUM@1224|Proteobacteria,1RP5J@1236|Gammaproteobacteria 1236|Gammaproteobacteria G COG2211 Na melibiose symporter and related transporters - - - - - - - - - - - - MFS_2 k59_1201629_1 234267.Acid_5307 8.05e-52 191.0 COG0508@1|root,COG0567@1|root,COG0508@2|Bacteria,COG0567@2|Bacteria,3Y3EF@57723|Acidobacteria 57723|Acidobacteria C 2-oxoglutarate dehydrogenase, E1 - - 1.2.4.2 ko:K00164 ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00032 R00621,R01933,R01940,R03316,R08549 RC00004,RC00027,RC00627,RC02743,RC02833,RC02883 br01601,ko00000,ko00001,ko00002,ko01000 - - - 2-oxoacid_dh,E1_dh,OxoGdeHyase_C,Transket_pyr k59_1766396_1 1550073.JROH01000014_gene90 6.64e-16 70.5 COG0745@1|root,COG0745@2|Bacteria,1RHDD@1224|Proteobacteria,2UA4W@28211|Alphaproteobacteria,2K5CB@204457|Sphingomonadales 204457|Sphingomonadales T response regulator - - - ko:K03413 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko02022,ko02035 - - - Response_reg k59_1766396_2 1096930.L284_05450 3.83e-62 211.0 COG0643@1|root,COG0643@2|Bacteria,1MUAG@1224|Proteobacteria,2TSN2@28211|Alphaproteobacteria,2K08K@204457|Sphingomonadales 204457|Sphingomonadales NT CheA signal transduction histidine kinase - - 2.7.13.3 ko:K03407 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 - - - CheW,H-kinase_dim,HATPase_c,Hpt k59_354760_1 316407.1736572 6.49e-133 392.0 COG0322@1|root,COG0322@2|Bacteria,1MV38@1224|Proteobacteria,1RNGV@1236|Gammaproteobacteria,3XNGD@561|Escherichia 1236|Gammaproteobacteria L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision uvrC GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009314,GO:0009380,GO:0009381,GO:0009628,GO:0009987,GO:0016787,GO:0016788,GO:0032991,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1902494,GO:1905347,GO:1905348,GO:1990391 - ko:K03703 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - GIY-YIG,HHH,HHH_2,HHH_5,UVR,UvrC_HhH_N k59_918919_1 330214.NIDE1834 4.65e-49 166.0 COG3547@1|root,COG3547@2|Bacteria,3J17W@40117|Nitrospirae 40117|Nitrospirae L hmm pf02371 - - - ko:K07486 - - - - ko00000 - - - DEDD_Tnp_IS110,Transposase_20 k59_1088401_1 1144305.PMI02_00565 3.97e-19 89.4 COG1187@1|root,COG1187@2|Bacteria,1MUCE@1224|Proteobacteria,2TQP2@28211|Alphaproteobacteria,2K0YS@204457|Sphingomonadales 204457|Sphingomonadales J Belongs to the pseudouridine synthase RsuA family rluB - 5.4.99.22 ko:K06178 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2,S4 k59_1371521_1 583355.Caka_2422 2.43e-21 89.7 2DTM2@1|root,33KVG@2|Bacteria,46T9U@74201|Verrucomicrobia,3K8F9@414999|Opitutae 414999|Opitutae - - - - - - - - - - - - - - - k59_1144614_1 172088.AUGA01000022_gene623 1.08e-78 261.0 COG1215@1|root,COG5309@1|root,COG1215@2|Bacteria,COG5309@2|Bacteria,1MWF8@1224|Proteobacteria,2VEZT@28211|Alphaproteobacteria,3JTNP@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria M Glycosyl transferase family 21 MA20_12920 - 2.4.1.12,3.2.1.58 ko:K00694,ko:K01210 ko00500,ko01100,ko02026,map00500,map01100,map02026 - R00308,R02889,R03115 RC00005,RC00467 ko00000,ko00001,ko01000,ko01003,ko02000 4.D.3.1.2,4.D.3.1.5,4.D.3.1.6 GT2 - Glyco_hydro_17,Glyco_tranf_2_3,Glyco_trans_2_3 k59_15293_1 926569.ANT_07910 1.97e-10 66.2 COG0845@1|root,COG0845@2|Bacteria,2G8US@200795|Chloroflexi 200795|Chloroflexi M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - ko:K02005,ko:K13888 - M00709 - - ko00000,ko00002,ko02000 8.A.1 - - Biotin_lipoyl_2,HlyD_3,HlyD_D23 k59_1596889_1 1123037.AUDE01000001_gene1824 1.5e-156 482.0 COG1404@1|root,COG3227@1|root,COG3291@1|root,COG4733@1|root,COG4935@1|root,COG1404@2|Bacteria,COG3227@2|Bacteria,COG3291@2|Bacteria,COG4733@2|Bacteria,COG4935@2|Bacteria,4NF8H@976|Bacteroidetes,1IJ61@117743|Flavobacteriia 976|Bacteroidetes E Thermolysin metallopeptidase, catalytic domain - - - - - - - - - - - - DUF5011,MAM,Peptidase_M14,Peptidase_M43,Reprolysin_4,fn3 k59_1257735_1 1131462.DCF50_p2326 2.89e-25 109.0 COG0784@1|root,COG2202@1|root,COG3829@1|root,COG5002@1|root,COG0784@2|Bacteria,COG2202@2|Bacteria,COG3829@2|Bacteria,COG5002@2|Bacteria,1TSDF@1239|Firmicutes,250SJ@186801|Clostridia,267B4@186807|Peptococcaceae 186801|Clostridia T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - HATPase_c,HisKA,Hpt,PAS_9,Response_reg k59_354771_1 378806.STAUR_0837 1.26e-06 55.5 COG0745@1|root,COG0745@2|Bacteria,1Q34X@1224|Proteobacteria,438VM@68525|delta/epsilon subdivisions,2X41B@28221|Deltaproteobacteria,2YZYK@29|Myxococcales 28221|Deltaproteobacteria T cheY-homologous receiver domain - - - - - - - - - - - - Response_reg k59_1088413_1 330214.NIDE4248 3.53e-55 181.0 COG2801@1|root,COG2801@2|Bacteria 2|Bacteria L transposition - - - ko:K07497 - - - - ko00000 - - - HTH_21,rve k59_919726_2 1121422.AUMW01000021_gene1680 5.16e-20 87.8 COG4227@1|root,COG4227@2|Bacteria,1UY3K@1239|Firmicutes,24HPV@186801|Clostridia 186801|Clostridia L Domain of unknown function (DUF1738) - - - - - - - - - - - - DUF1738 k59_299186_1 1280953.HOC_01671 1.28e-25 99.0 COG0640@1|root,COG0640@2|Bacteria,1N72Q@1224|Proteobacteria,2UFSY@28211|Alphaproteobacteria,43YNK@69657|Hyphomonadaceae 28211|Alphaproteobacteria K helix_turn_helix, Arsenical Resistance Operon Repressor nolR GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0044212,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1903506,GO:2000112,GO:2001141 - ko:K22042 - - - - ko00000,ko03000 - - - HTH_5 k59_1494267_1 1317122.ATO12_00580 7.36e-132 380.0 COG3774@1|root,COG3774@2|Bacteria,4NITG@976|Bacteroidetes,1I139@117743|Flavobacteriia,2YGPI@290174|Aquimarina 976|Bacteroidetes M Polysaccharide pyruvyl transferase - - - - - - - - - - - - PS_pyruv_trans k59_1494267_2 1121007.AUML01000024_gene338 8.87e-60 198.0 arCOG10304@1|root,30WUR@2|Bacteria,4NGAA@976|Bacteroidetes,1HZC7@117743|Flavobacteriia,2YGWM@290174|Aquimarina 976|Bacteroidetes - - - - - - - - - - - - - - - k59_1550616_1 748280.NH8B_2466 1.74e-16 73.2 2E70X@1|root,331JP@2|Bacteria 2|Bacteria S Putative F0F1-ATPase subunit Ca2+/Mg2+ transporter - - - ko:K02116 - - - - ko00000,ko00194 3.A.2.1 - - ATPase_gene1 k59_1550616_2 522306.CAP2UW1_2679 6.07e-63 200.0 COG0356@1|root,COG0356@2|Bacteria,1RBEV@1224|Proteobacteria,2WGC1@28216|Betaproteobacteria 28216|Betaproteobacteria C it plays a direct role in the translocation of protons across the membrane - - - ko:K02108 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko03110 3.A.2.1 - - ATP-synt_A k59_250046_1 1122137.AQXF01000004_gene1762 7.9e-86 270.0 COG2759@1|root,COG2759@2|Bacteria,1MUR8@1224|Proteobacteria,2TRMM@28211|Alphaproteobacteria 28211|Alphaproteobacteria H Belongs to the formate--tetrahydrofolate ligase family fhs - 6.3.4.3 ko:K01938 ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200 M00140,M00377 R00943 RC00026,RC00111 ko00000,ko00001,ko00002,ko01000 - - - FTHFS k59_474885_1 1149133.ppKF707_2711 6.64e-24 102.0 COG4313@1|root,COG4313@2|Bacteria,1R58D@1224|Proteobacteria,1RYZE@1236|Gammaproteobacteria,1YGXK@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria C Putative MetA-pathway of phenol degradation - - - - - - - - - - - - Phenol_MetA_deg k59_1435245_2 1317124.DW2_03004 4.03e-16 76.6 COG4315@1|root,COG4315@2|Bacteria,1MZC6@1224|Proteobacteria,2UCKS@28211|Alphaproteobacteria,2XPGJ@285107|Thioclava 28211|Alphaproteobacteria S Secreted repeat of unknown function MA20_31645 - - - - - - - - - - - Lipoprotein_15 k59_364522_2 1122137.AQXF01000003_gene2067 7.33e-233 646.0 COG0505@1|root,COG0505@2|Bacteria,1MUB9@1224|Proteobacteria,2TR3W@28211|Alphaproteobacteria 28211|Alphaproteobacteria F Belongs to the CarA family carA GO:0000050,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005951,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0019627,GO:0019752,GO:0032991,GO:0034641,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494 6.3.5.5 ko:K01956 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - - CPSase_sm_chain,GATase k59_1719487_1 1122137.AQXF01000001_gene2761 1.26e-91 294.0 COG2866@1|root,COG2866@2|Bacteria,1N9W9@1224|Proteobacteria,2U2SA@28211|Alphaproteobacteria 28211|Alphaproteobacteria E carboxypeptidase - - - - - - - - - - - - Peptidase_M14 k59_1096737_1 96561.Dole_0362 6.44e-69 221.0 COG2211@1|root,COG2211@2|Bacteria,1QVH9@1224|Proteobacteria,43BQR@68525|delta/epsilon subdivisions,2X71T@28221|Deltaproteobacteria,2MKDF@213118|Desulfobacterales 28221|Deltaproteobacteria G Sugar (and other) transporter - - - - - - - - - - - - MFS_1 k59_872969_1 1415778.JQMM01000001_gene755 8.44e-175 504.0 COG0187@1|root,COG0187@2|Bacteria,1MVH1@1224|Proteobacteria,1RMCI@1236|Gammaproteobacteria,1J4HN@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule parE - - ko:K02622 - - - - ko00000,ko01000,ko02048,ko03032,ko03036 - - - DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim k59_137726_1 305900.GV64_04020 3.22e-23 103.0 COG0729@1|root,COG0729@2|Bacteria,1MUKM@1224|Proteobacteria,1RNQ3@1236|Gammaproteobacteria,1XHG0@135619|Oceanospirillales 135619|Oceanospirillales M COG0729 Outer membrane protein - - - ko:K07278 - - - - ko00000,ko02000 1.B.33.2.4 - - Bac_surface_Ag,POTRA,POTRA_TamA_1 k59_1042715_1 1206101.AZXC01000022_gene5705 5.9e-16 80.1 COG1017@1|root,COG1018@1|root,COG1017@2|Bacteria,COG1018@2|Bacteria,2GKXT@201174|Actinobacteria 201174|Actinobacteria C Belongs to the globin family fhbA - - - - - - - - - - - FAD_binding_6,Globin,NAD_binding_1 k59_1381032_1 311424.DhcVS_930 3.71e-33 123.0 COG1173@1|root,COG1173@2|Bacteria,2G9WH@200795|Chloroflexi,34DKE@301297|Dehalococcoidia 301297|Dehalococcoidia EP N-terminal TM domain of oligopeptide transport permease C - - - ko:K15582 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00439 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 - - BPD_transp_1,OppC_N k59_1381032_2 278957.ABEA03000201_gene4325 1.01e-20 94.4 COG0444@1|root,COG4608@1|root,COG0444@2|Bacteria,COG4608@2|Bacteria,46U8E@74201|Verrucomicrobia,3KA26@414999|Opitutae 414999|Opitutae P Oligopeptide/dipeptide transporter, C-terminal region - - - ko:K10823 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00439 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 - - ABC_tran,oligo_HPY k59_250068_1 309801.trd_A0709 5.62e-33 128.0 COG2377@1|root,COG2377@2|Bacteria,2G7X8@200795|Chloroflexi,27YT7@189775|Thermomicrobia 189775|Thermomicrobia O Anhydro-N-acetylmuramic acid kinase - - 2.7.1.170 ko:K09001 - - - - ko00000,ko01000 - - - AnmK k59_927125_1 1229909.NSED_03175 2.77e-42 142.0 COG2042@1|root,arCOG04733@2157|Archaea,41SMC@651137|Thaumarchaeota 651137|Thaumarchaeota S Ribosome biogenesis protein, C-terminal - - - ko:K09140 - - - - ko00000,ko03009 - - - RLI,Ribo_biogen_C k59_927125_2 1229909.NSED_03180 9.86e-72 240.0 COG3889@1|root,arCOG01672@2157|Archaea,41SA5@651137|Thaumarchaeota 651137|Thaumarchaeota S Bacterial extracellular solute-binding proteins, family 5 Middle - - - ko:K02035 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - SBP_bac_5 k59_1435266_1 1122137.AQXF01000003_gene2345 7.61e-109 324.0 COG0104@1|root,COG0104@2|Bacteria,1MU5B@1224|Proteobacteria,2TRKY@28211|Alphaproteobacteria 28211|Alphaproteobacteria F Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP purA GO:0003674,GO:0003824,GO:0004019,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046033,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.4.4 ko:K01939 ko00230,ko00250,ko01100,map00230,map00250,map01100 M00049 R01135 RC00458,RC00459 ko00000,ko00001,ko00002,ko01000 - - - Adenylsucc_synt k59_589301_1 1144305.PMI02_00578 4.11e-47 162.0 COG0538@1|root,COG0538@2|Bacteria,1MUIB@1224|Proteobacteria,2TQWD@28211|Alphaproteobacteria,2K05F@204457|Sphingomonadales 204457|Sphingomonadales C Belongs to the isocitrate and isopropylmalate dehydrogenases family icd - 1.1.1.42 ko:K00031 ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146 M00009,M00010,M00173,M00740 R00267,R00268,R01899 RC00001,RC00084,RC00114,RC00626,RC02801 br01601,ko00000,ko00001,ko00002,ko01000 - - - Iso_dh k59_589301_2 1122137.AQXF01000002_gene406 4.58e-100 303.0 COG0664@1|root,COG0664@2|Bacteria,1QU34@1224|Proteobacteria,2TVH6@28211|Alphaproteobacteria 28211|Alphaproteobacteria T COG1226 Kef-type K transport systems - GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0042802,GO:0044464,GO:0071944 - ko:K10716 - - - - ko00000,ko02000 1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6 - - Ion_trans,Ion_trans_2,cNMP_binding k59_1494316_1 1116472.MGMO_34c00260 4.66e-46 166.0 COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,1RQX2@1236|Gammaproteobacteria,1XEHZ@135618|Methylococcales 135618|Methylococcales C FAD linked oxidases, C-terminal domain glcD - 1.1.3.15 ko:K00104 ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130 - R00475 RC00042 ko00000,ko00001,ko01000 - - - FAD-oxidase_C,FAD_binding_4 k59_927137_1 316407.85674494 4.89e-119 347.0 COG0119@1|root,COG0119@2|Bacteria,1MVQG@1224|Proteobacteria,1RPPW@1236|Gammaproteobacteria,3XQEH@561|Escherichia 1236|Gammaproteobacteria E Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of mhpE GO:0003674,GO:0003824,GO:0008701,GO:0016829,GO:0016830,GO:0016833 2.3.3.13,4.1.3.39 ko:K01649,ko:K01666 ko00290,ko00360,ko00362,ko00620,ko00621,ko00622,ko01100,ko01110,ko01120,ko01210,ko01220,ko01230,map00290,map00360,map00362,map00620,map00621,map00622,map01100,map01110,map01120,map01210,map01220,map01230 M00432,M00545,M00569 R00750,R01213 RC00004,RC00307,RC00371,RC00470,RC02754 br01601,br01602,ko00000,ko00001,ko00002,ko01000 - - iECIAI39_1322.ECIAI39_0326,iEcSMS35_1347.EcSMS35_0383,iYL1228.KPN_02117 DmpG_comm,HMGL-like k59_307792_1 702113.PP1Y_AT24969 3.11e-134 390.0 COG0148@1|root,COG0148@2|Bacteria,1MU1N@1224|Proteobacteria,2TR04@28211|Alphaproteobacteria,2K00W@204457|Sphingomonadales 204457|Sphingomonadales G Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis eno - 4.2.1.11 ko:K01689 ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066 M00001,M00002,M00003,M00346,M00394 R00658 RC00349 ko00000,ko00001,ko00002,ko01000,ko03019,ko04147 - - - Enolase_C,Enolase_N k59_927139_1 329726.AM1_3560 1.68e-39 144.0 COG1396@1|root,COG1396@2|Bacteria,1G398@1117|Cyanobacteria 1117|Cyanobacteria K Transcriptional regulator - - - - - - - - - - - - HTH_3,HTH_31 k59_250092_1 1121912.AUHD01000004_gene2048 2.45e-29 115.0 COG3391@1|root,COG4124@1|root,COG3391@2|Bacteria,COG4124@2|Bacteria,4NEZG@976|Bacteroidetes,1HZEF@117743|Flavobacteriia 976|Bacteroidetes G Belongs to the glycosyl hydrolase 26 family - - 3.2.1.78 ko:K01218 ko00051,ko02024,map00051,map02024 - R01332 RC00467 ko00000,ko00001,ko01000 - GH26 - Calx-beta,Glyco_hydro_26 k59_250092_2 1123234.AUKI01000011_gene1447 5e-41 148.0 COG3934@1|root,COG3934@2|Bacteria,4NH10@976|Bacteroidetes,1HZPB@117743|Flavobacteriia 976|Bacteroidetes G Belongs to the glycosyl hydrolase 5 (cellulase A) family - - 3.2.1.78 ko:K19355 ko00051,map00051 - R01332 RC00467 ko00000,ko00001,ko01000 - - - Cellulase,Glyco_hydro_42 k59_1773896_1 863365.XHC_0102 2.38e-18 79.7 COG0500@1|root,COG0500@2|Bacteria,1RDHE@1224|Proteobacteria,1S3U0@1236|Gammaproteobacteria,1X6QC@135614|Xanthomonadales 135614|Xanthomonadales Q Protein of unknown function (DUF938) - - - - - - - - - - - - DUF938 k59_1773896_2 402626.Rpic_0813 9.55e-61 193.0 COG1949@1|root,COG1949@2|Bacteria,1R9WX@1224|Proteobacteria,2VIA2@28216|Betaproteobacteria,1K394@119060|Burkholderiaceae 28216|Betaproteobacteria L 3'-to-5' exoribonuclease specific for small oligoribonucleotides orn - - ko:K13288 ko03008,map03008 - - - ko00000,ko00001,ko01000,ko03009,ko03019 - - - RNase_T k59_419519_1 631454.N177_3894 7.05e-19 87.4 COG0651@1|root,COG0651@2|Bacteria,1MURB@1224|Proteobacteria,2TRQ2@28211|Alphaproteobacteria,1JP3A@119043|Rhodobiaceae 28211|Alphaproteobacteria CP Proton-conducting membrane transporter nuoN2 - 1.6.5.3 ko:K00343,ko:K05568 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000,ko02000 2.A.63.1,2.A.63.2,3.D.1 - - Proton_antipo_M k59_419519_2 1454004.AW11_02853 1.65e-50 163.0 COG1006@1|root,COG1006@2|Bacteria,1RGU1@1224|Proteobacteria 1224|Proteobacteria P COG1006 Multisubunit Na H antiporter, MnhC subunit mnhC - - ko:K05567 - - - - ko00000,ko02000 2.A.63.1,2.A.63.2 - - Oxidored_q2 k59_419519_3 1454004.AW11_02852 3.41e-39 134.0 COG2111@1|root,COG2111@2|Bacteria,1N1CK@1224|Proteobacteria 1224|Proteobacteria P Na H antiporter, MnhB - - - ko:K05566 - - - - ko00000,ko02000 2.A.63.1,2.A.63.2 - - DUF4040,MnhB k59_1550676_2 1122599.AUGR01000006_gene3724 4.94e-111 332.0 COG2821@1|root,COG2821@2|Bacteria,1MXD4@1224|Proteobacteria,1RP7K@1236|Gammaproteobacteria,1XK0I@135619|Oceanospirillales 135619|Oceanospirillales M MltA specific insert domain - - - ko:K08304 - - - - ko00000,ko01000,ko01011 - GH102 - 3D,MltA k59_644588_1 1122137.AQXF01000002_gene80 4.67e-76 246.0 COG2146@1|root,COG2146@2|Bacteria 2|Bacteria P nitrite reductase [NAD(P)H] activity - - - ko:K15762 ko00623,ko00920,ko01100,ko01120,ko01220,map00623,map00920,map01100,map01120,map01220 M00538 R02550,R03562,R05666,R09513 RC00269,RC00490,RC02556 ko00000,ko00001,ko00002 - - - Glu_synthase,Rieske k59_1662419_1 1121939.L861_09375 5.21e-51 181.0 COG0398@1|root,COG1249@1|root,COG0398@2|Bacteria,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,1RQTU@1236|Gammaproteobacteria,1XHNV@135619|Oceanospirillales 135619|Oceanospirillales C Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family - - - - - - - - - - - - Pyr_redox_2,Pyr_redox_dim,SNARE_assoc k59_1381064_1 864051.BurJ1DRAFT_2494 8.58e-50 172.0 COG0460@1|root,COG0460@2|Bacteria,1MUDC@1224|Proteobacteria,2VH9T@28216|Betaproteobacteria,1KJ3I@119065|unclassified Burkholderiales 28216|Betaproteobacteria E homoserine dehydrogenase hom - 1.1.1.3 ko:K00003 ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230 M00017,M00018 R01773,R01775 RC00087 ko00000,ko00001,ko00002,ko01000 - - - ACT,Homoserine_dh,NAD_binding_3 k59_250103_2 436308.Nmar_0041 2.91e-09 57.0 COG0083@1|root,arCOG01027@2157|Archaea,41S89@651137|Thaumarchaeota 651137|Thaumarchaeota E Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate thrB - 2.7.1.39 ko:K00872 ko00260,ko01100,ko01110,ko01120,ko01230,map00260,map01100,map01110,map01120,map01230 M00018 R01771 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - GHMP_kinases_C,GHMP_kinases_N k59_927147_1 234267.Acid_7271 5.18e-51 183.0 COG0421@1|root,COG0421@2|Bacteria,3Y6UP@57723|Acidobacteria 57723|Acidobacteria E Spermine/spermidine synthase domain - - - - - - - - - - - - Spermine_synth k59_1042763_1 1197477.IA57_10660 2.69e-78 253.0 COG0210@1|root,COG0210@2|Bacteria,4NDWN@976|Bacteroidetes,1HWYD@117743|Flavobacteriia 976|Bacteroidetes L DNA helicase pcrA - 3.6.4.12 ko:K03657 ko03420,ko03430,map03420,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - UvrD-helicase,UvrD_C k59_137781_1 314254.OA2633_14950 2.3e-05 53.9 COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,2TQPZ@28211|Alphaproteobacteria,43X8X@69657|Hyphomonadaceae 28211|Alphaproteobacteria O Belongs to the peptidase S1C family dop GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005575,GO:0005623,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0016787,GO:0017171,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043170,GO:0044238,GO:0044464,GO:0070011,GO:0071704,GO:0140096,GO:1901564 3.4.21.107 ko:K04771 ko01503,ko02020,map01503,map02020 M00728 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 - - - PDZ_2,Trypsin_2 k59_1381078_1 502025.Hoch_1780 1.13e-95 301.0 COG0855@1|root,COG0855@2|Bacteria,1MUM3@1224|Proteobacteria,42NN7@68525|delta/epsilon subdivisions,2WJG7@28221|Deltaproteobacteria,2YUAP@29|Myxococcales 28221|Deltaproteobacteria H Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) ppk - 2.7.4.1 ko:K00937 ko00190,ko03018,map00190,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - PP_kinase,PP_kinase_C,PP_kinase_N k59_530600_1 522306.CAP2UW1_4329 5.77e-38 133.0 COG3917@1|root,COG3917@2|Bacteria,1RDNQ@1224|Proteobacteria,2VQJ1@28216|Betaproteobacteria,1KQTA@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria Q DSBA-like thioredoxin domain - - 5.99.1.4 ko:K14584 ko00626,ko01100,ko01120,ko01220,map00626,map01100,map01120,map01220 M00534 R05137 RC03084 br01602,ko00000,ko00001,ko00002,ko01000 - - - DSBA k59_530600_2 648757.Rvan_3409 3.43e-31 118.0 COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,2TQKE@28211|Alphaproteobacteria,3N9EF@45401|Hyphomicrobiaceae 28211|Alphaproteobacteria C Acyl-CoA dehydrogenase, C-terminal domain - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_644603_1 247634.GPB2148_52 2.66e-108 320.0 COG1082@1|root,COG1082@2|Bacteria,1MVSJ@1224|Proteobacteria,1RRKK@1236|Gammaproteobacteria,1J5MG@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L AP endonuclease family 2 C terminus - - - - - - - - - - - - AP_endonuc_2,AP_endonuc_2_N k59_419535_1 640081.Dsui_1209 2.86e-79 256.0 COG0568@1|root,COG0568@2|Bacteria,1MVNJ@1224|Proteobacteria,2VH74@28216|Betaproteobacteria,2KVA2@206389|Rhodocyclales 206389|Rhodocyclales K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth rpoD - - ko:K03086 - - - - ko00000,ko03021 - - - Sigma70_ner,Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4 k59_1494355_1 1565129.JSFF01000006_gene2554 4.98e-132 385.0 COG1680@1|root,COG1680@2|Bacteria,1P3SQ@1224|Proteobacteria,1SWQX@1236|Gammaproteobacteria,2QCYP@267890|Shewanellaceae 1236|Gammaproteobacteria V Beta-lactamase - - - - - - - - - - - - Beta-lactamase k59_873033_1 765911.Thivi_3181 9.97e-40 147.0 COG4656@1|root,COG4656@2|Bacteria,1QTUI@1224|Proteobacteria,1RMIM@1236|Gammaproteobacteria,1WXET@135613|Chromatiales 135613|Chromatiales C Part of a membrane complex involved in electron transport - - - ko:K03615 - - - - ko00000 - - - Complex1_51K,Fer4_8,RnfC_N,SLBB k59_1153856_1 98439.AJLL01000022_gene924 1.22e-58 199.0 COG1132@1|root,COG1132@2|Bacteria,1GI0Z@1117|Cyanobacteria,1JJX7@1189|Stigonemataceae 1117|Cyanobacteria V ABC transporter transmembrane region - - - - - - - - - - - - ABC_membrane,ABC_tran k59_24995_1 997296.PB1_15539 1.25e-21 100.0 COG0507@1|root,COG0507@2|Bacteria,1TPZH@1239|Firmicutes,4HATQ@91061|Bacilli,1ZAYS@1386|Bacillus 91061|Bacilli L DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity recD2 - 3.1.11.5 ko:K03581 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - AAA_30,HHH_4,HHH_5,UvrD_C_2 k59_137796_1 1089550.ATTH01000001_gene2276 3.09e-56 192.0 COG0141@1|root,COG0141@2|Bacteria,4NFPZ@976|Bacteroidetes,1FIVP@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes E Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine hisD GO:0000105,GO:0003674,GO:0003824,GO:0004399,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0052803,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.23 ko:K00013 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R01158,R01163,R03012 RC00099,RC00242,RC00463 ko00000,ko00001,ko00002,ko01000 - - - Histidinol_dh k59_307833_1 706587.Desti_3883 2.05e-30 120.0 COG0564@1|root,COG0564@2|Bacteria,1MUBN@1224|Proteobacteria,42MBA@68525|delta/epsilon subdivisions,2WKX9@28221|Deltaproteobacteria,2MQGD@213462|Syntrophobacterales 28221|Deltaproteobacteria J Responsible for synthesis of pseudouridine from uracil rluD - 5.4.99.23 ko:K06180 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2,S4 k59_137798_1 1353537.TP2_09630 2.18e-48 172.0 28HPH@1|root,2Z7XH@2|Bacteria,1Q80I@1224|Proteobacteria,2TVGE@28211|Alphaproteobacteria,2XM8R@285107|Thioclava 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_644617_1 1121957.ATVL01000012_gene663 1e-58 193.0 COG0667@1|root,COG0667@2|Bacteria,4NEDK@976|Bacteroidetes,47KVC@768503|Cytophagia 976|Bacteroidetes C Aldo/keto reductase family - - - - - - - - - - - - Aldo_ket_red k59_702620_1 870187.Thini_2577 5.2e-103 307.0 COG0540@1|root,COG0540@2|Bacteria,1MWAB@1224|Proteobacteria,1RPSV@1236|Gammaproteobacteria,460SK@72273|Thiotrichales 72273|Thiotrichales F Belongs to the ATCase OTCase family pyrB - 2.1.3.2 ko:K00609 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R01397 RC00064,RC02850 ko00000,ko00001,ko00002,ko01000 - - - OTCace,OTCace_N k59_250930_1 1088721.NSU_4150 5.71e-162 467.0 COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,2TSB1@28211|Alphaproteobacteria,2K1IG@204457|Sphingomonadales 204457|Sphingomonadales EH Belongs to the TPP enzyme family - - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_1551694_1 1440774.Y900_004990 1.65e-38 145.0 COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,2GMN4@201174|Actinobacteria,2337W@1762|Mycobacteriaceae 201174|Actinobacteria H Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate ppsA - 2.7.9.1,2.7.9.2 ko:K01006,ko:K01007,ko:K21787 ko00333,ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01130,ko01200,map00333,map00620,map00680,map00710,map00720,map01100,map01120,map01130,map01200 M00169,M00171,M00172,M00173,M00374,M00837,M00838 R00199,R00206,R11662,R11673 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - PEP-utilizers,PEP-utilizers_C,PPDK_N k59_1381950_1 768671.ThimaDRAFT_1303 4.41e-34 133.0 COG3064@1|root,COG3064@2|Bacteria,1RINZ@1224|Proteobacteria,1S7TN@1236|Gammaproteobacteria,1WYR1@135613|Chromatiales 135613|Chromatiales M Domain of unknown function (DUF4350) - - - - - - - - - - - - DUF4350 k59_138646_1 1282876.BAOK01000001_gene1433 3.38e-88 279.0 28HMZ@1|root,2Z7WD@2|Bacteria,1MU3Q@1224|Proteobacteria,2TSGX@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Protein of unknown function (DUF3604) - - - - - - - - - - - - DUF3604 k59_1323483_1 436308.Nmar_0001 2.05e-116 343.0 COG1474@1|root,arCOG00467@2157|Archaea,41SED@651137|Thaumarchaeota 651137|Thaumarchaeota L Involved in regulation of DNA replication - - - ko:K10725 - - - - ko00000,ko03032 - - - AAA_22,Cdc6_C k59_1720468_1 1121897.AUGO01000001_gene1229 5.53e-101 307.0 COG1032@1|root,COG1032@2|Bacteria,4NH8Y@976|Bacteroidetes,1HZR8@117743|Flavobacteriia,2NSS4@237|Flavobacterium 976|Bacteroidetes C B12 binding domain - - - - - - - - - - - - B12-binding,Radical_SAM k59_25910_1 1163617.SCD_n00575 4.92e-55 179.0 COG1127@1|root,COG1127@2|Bacteria,1MUSD@1224|Proteobacteria,2VJIA@28216|Betaproteobacteria 28216|Betaproteobacteria Q abc transporter ttg2A - - ko:K02065 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - ABC_tran k59_927764_1 930169.B5T_03706 2.07e-32 123.0 COG4105@1|root,COG4105@2|Bacteria,1MVS5@1224|Proteobacteria,1RSE6@1236|Gammaproteobacteria,1XJHK@135619|Oceanospirillales 135619|Oceanospirillales M Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane bamD - - ko:K05807 - - - - ko00000,ko02000 1.B.33.1 - - YfiO k59_25915_1 686340.Metal_1537 2.76e-148 437.0 COG0481@1|root,COG0481@2|Bacteria,1MVZA@1224|Proteobacteria,1RPFB@1236|Gammaproteobacteria,1XE1C@135618|Methylococcales 135618|Methylococcales J Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner lepA - - ko:K03596 ko05134,map05134 - - - ko00000,ko00001 - - - EFG_C,EFG_II,GTP_EFTU,GTP_EFTU_D2,LepA_C k59_1551724_1 936455.KI421499_gene3749 5.22e-108 323.0 COG0683@1|root,COG0683@2|Bacteria,1N11P@1224|Proteobacteria,2TRQ4@28211|Alphaproteobacteria,3JVI6@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria E Periplasmic binding protein - - - ko:K01999 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - Peripla_BP_6 k59_1211939_1 1229205.BUPH_01487 7.46e-51 182.0 COG0296@1|root,COG0296@2|Bacteria,1QTVN@1224|Proteobacteria,2VGZZ@28216|Betaproteobacteria,1K0ZA@119060|Burkholderiaceae 28216|Betaproteobacteria G Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position glgB - 2.4.1.18 ko:K00700 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R02110 - ko00000,ko00001,ko00002,ko01000,ko04147 - CBM48,GH13 - Alpha-amylase,Alpha-amylase_C,CBM_48,Glyco_hydro_77 k59_1211939_2 757424.Hsero_2500 5.36e-21 100.0 COG1640@1|root,COG1640@2|Bacteria,1QTVJ@1224|Proteobacteria,2VMMN@28216|Betaproteobacteria,47891@75682|Oxalobacteraceae 28216|Betaproteobacteria G 4-alpha-glucanotransferase malQ - 2.4.1.25 ko:K00705 ko00500,ko01100,map00500,map01100 - R05196 RC00049 ko00000,ko00001,ko01000 - GH77 - Glyco_hydro_77 k59_83110_1 1122137.AQXF01000001_gene2778 6.81e-76 239.0 2C57D@1|root,2Z7RS@2|Bacteria,1MX6G@1224|Proteobacteria,2TTDU@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Protein of unknown function (DUF2891) - - - - - - - - - - - - DUF2891 k59_83110_2 1122137.AQXF01000001_gene2775 3.81e-190 556.0 COG1752@1|root,COG1752@2|Bacteria,1MWH2@1224|Proteobacteria,2TU16@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Protein of unknown function (DUF3376) - - - - - - - - - - - - DUF3376,Patatin k59_1323496_1 1449350.OCH239_20365 4.05e-83 257.0 COG3328@1|root,COG3328@2|Bacteria,1MU4P@1224|Proteobacteria,2TTAW@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Transposase - - - - - - - - - - - - Transposase_mut k59_758009_1 316407.85675396 1.97e-109 333.0 COG0272@1|root,COG0272@2|Bacteria,1MV3R@1224|Proteobacteria,1RPAV@1236|Gammaproteobacteria,3XMQY@561|Escherichia 1236|Gammaproteobacteria L DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA ligA GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003909,GO:0003911,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016874,GO:0016886,GO:0033554,GO:0034641,GO:0034645,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050662,GO:0050896,GO:0051103,GO:0051287,GO:0051716,GO:0070403,GO:0071704,GO:0090304,GO:0097159,GO:0140097,GO:1901265,GO:1901360,GO:1901363,GO:1901576 6.5.1.2 ko:K01972 ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430 - R00382 RC00005 ko00000,ko00001,ko01000,ko03032,ko03400 - - iEC55989_1330.EC55989_2701,iECABU_c1320.ECABU_c27320,iECIAI1_1343.ECIAI1_2469,iECO103_1326.ECO103_2930,iECO111_1330.ECO111_3141,iECO26_1355.ECO26_3464,iECSE_1348.ECSE_2702,iECW_1372.ECW_m2640,iEKO11_1354.EKO11_1317,iEcE24377_1341.EcE24377A_2698,iEcSMS35_1347.EcSMS35_2566,iWFL_1372.ECW_m2640,iYL1228.KPN_02758,ic_1306.c2945 BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5 k59_1381987_1 436308.Nmar_0258 1.18e-111 336.0 COG1053@1|root,arCOG00571@2157|Archaea,41SAM@651137|Thaumarchaeota 651137|Thaumarchaeota C fumarate reductase flavoprotein - - 1.3.5.1,1.3.5.4 ko:K00239 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134 M00009,M00011,M00149,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,Succ_DH_flav_C k59_91749_1 1157708.KB907459_gene2156 2.23e-23 96.3 COG3917@1|root,COG3917@2|Bacteria,1MWB9@1224|Proteobacteria,2WFRW@28216|Betaproteobacteria,4ADQJ@80864|Comamonadaceae 28216|Betaproteobacteria Q DSBA-like thioredoxin domain - - - - - - - - - - - - DSBA k59_1562421_1 521000.PROVRETT_07967 7.27e-05 45.4 COG4559@1|root,COG4559@2|Bacteria,1RD7N@1224|Proteobacteria,1RPUV@1236|Gammaproteobacteria,3Z746@586|Providencia 1236|Gammaproteobacteria P Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system hmuV - 3.6.3.34 ko:K02013 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.14 - - ABC_tran k59_1562421_2 227377.CBU_0383 3.79e-32 118.0 COG2818@1|root,COG2818@2|Bacteria,1R9X5@1224|Proteobacteria,1S25K@1236|Gammaproteobacteria,1JCQG@118969|Legionellales 118969|Legionellales L Methyladenine glycosylase tag - 3.2.2.20 ko:K01246 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - Adenine_glyco k59_1505132_1 1333998.M2A_2710 7.7e-58 194.0 COG3203@1|root,COG3203@2|Bacteria,1R5I5@1224|Proteobacteria,2TZUW@28211|Alphaproteobacteria 28211|Alphaproteobacteria M Phosphate-selective porin O and P - - - - - - - - - - - - Porin_O_P k59_1392102_1 1123400.KB904780_gene1911 5.91e-43 158.0 COG0493@1|root,COG1143@1|root,COG0493@2|Bacteria,COG1143@2|Bacteria,1MU2H@1224|Proteobacteria,1RREP@1236|Gammaproteobacteria,463NI@72273|Thiotrichales 72273|Thiotrichales C Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster - - - - - - - - - - - - Fer4_20,Fer4_7,Pyr_redox_2 k59_1780685_1 380358.XALC_1196 1.78e-82 257.0 COG2115@1|root,COG2115@2|Bacteria,1MXS2@1224|Proteobacteria,1RN5Y@1236|Gammaproteobacteria,1X4B9@135614|Xanthomonadales 135614|Xanthomonadales G Belongs to the xylose isomerase family xylA GO:0003674,GO:0003824,GO:0005975,GO:0005996,GO:0008150,GO:0008152,GO:0009045,GO:0009056,GO:0016052,GO:0016853,GO:0016860,GO:0016861,GO:0019321,GO:0019323,GO:0042732,GO:0042843,GO:0044238,GO:0044281,GO:0044282,GO:0046365,GO:0071704,GO:1901575 5.3.1.5 ko:K01805 ko00040,ko00051,ko01100,map00040,map00051,map01100 - R00878,R01432 RC00376,RC00516 ko00000,ko00001,ko01000 - - - - k59_203114_1 1286093.C266_06784 7.5e-29 115.0 COG1737@1|root,COG1737@2|Bacteria,1MV3U@1224|Proteobacteria,2VH1T@28216|Betaproteobacteria,1K19A@119060|Burkholderiaceae 28216|Betaproteobacteria K Transcriptional regulator hexR - - ko:K19337 - - - - ko00000,ko03000 - - - HTH_6,SIS k59_260803_1 1197477.IA57_03535 7.47e-101 307.0 COG1538@1|root,COG1538@2|Bacteria,4NF4X@976|Bacteroidetes,1HYW1@117743|Flavobacteriia 976|Bacteroidetes MU Outer membrane efflux protein - - - - - - - - - - - - OEP k59_1052360_1 1173024.KI912150_gene1284 2.48e-48 176.0 COG0737@1|root,COG2931@1|root,COG3391@1|root,COG0737@2|Bacteria,COG2931@2|Bacteria,COG3391@2|Bacteria,1G0YK@1117|Cyanobacteria,1JKJH@1189|Stigonemataceae 1117|Cyanobacteria F phosphatase - - 3.1.3.8 ko:K01083,ko:K07004 ko00562,map00562 - R03371 RC00078 ko00000,ko00001,ko01000 - - - 5_nucleotid_C,Calx-beta,DUF4114,Exo_endo_phos,LTD,Phytase-like,VPEP k59_990627_3 1229909.NSED_09390 2.55e-19 79.0 arCOG08748@1|root,arCOG08748@2157|Archaea,41TAF@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1104950_1 222984.JNCS01000013_gene1445 5.06e-06 53.1 COG1011@1|root,arCOG02291@2157|Archaea,2XXMA@28890|Euryarchaeota,23VH3@183963|Halobacteria 183963|Halobacteria S subfamily IA, variant 1 - - - ko:K07025 - - - - ko00000 - - - HAD_2 k59_823542_1 1121904.ARBP01000025_gene6077 2.1e-21 98.2 COG3464@1|root,COG3464@2|Bacteria,4NR8V@976|Bacteroidetes,47TD6@768503|Cytophagia 976|Bacteroidetes L Transposase - - - - - - - - - - - - UPF0236 k59_1163786_1 1197477.IA57_05405 3.56e-56 197.0 COG1196@1|root,COG1196@2|Bacteria,4NF7P@976|Bacteroidetes,1HYD4@117743|Flavobacteriia 976|Bacteroidetes D ATPase involved in DNA repair - - - - - - - - - - - - DUF4175 k59_260819_1 1123020.AUIE01000010_gene1146 1.63e-113 345.0 COG2132@1|root,COG2132@2|Bacteria,1MU0J@1224|Proteobacteria,1SZFR@1236|Gammaproteobacteria 1236|Gammaproteobacteria Q Multicopper oxidase - - 1.16.3.3 ko:K06324 - - - - ko00000,ko01000 - - - Cu-oxidase,Cu-oxidase_2,Cu-oxidase_3 k59_1052370_1 572477.Alvin_2036 4.46e-38 140.0 COG0374@1|root,COG0374@2|Bacteria,1MWFJ@1224|Proteobacteria,1RMC3@1236|Gammaproteobacteria,1WWEA@135613|Chromatiales 135613|Chromatiales C Belongs to the NiFe NiFeSe hydrogenase large subunit family - - 1.12.99.6 ko:K06281 ko00633,ko01120,map00633,map01120 - R08034 RC00250 ko00000,ko00001,ko01000 - - - NiFeSe_Hases k59_1052370_2 75379.Tint_2963 7.52e-29 115.0 COG0247@1|root,COG1139@1|root,COG0247@2|Bacteria,COG1139@2|Bacteria,1MUMH@1224|Proteobacteria,2VJGA@28216|Betaproteobacteria,1KN5P@119065|unclassified Burkholderiales 28216|Betaproteobacteria C Fe-S oxidoreductase - - - ko:K21834 - - - - ko00000 - - - CCG,DUF3483,Fer4_8 k59_1670586_1 1229909.NSED_07490 8.19e-113 330.0 COG0457@1|root,arCOG03038@2157|Archaea,41SMV@651137|Thaumarchaeota 651137|Thaumarchaeota S Transglutaminase-like superfamily - - - - - - - - - - - - TPR_9,Transglut_core2 k59_1163794_1 686340.Metal_0143 3e-48 175.0 COG4775@1|root,COG4775@2|Bacteria,1MU0D@1224|Proteobacteria,1RMAP@1236|Gammaproteobacteria,1XDRZ@135618|Methylococcales 135618|Methylococcales M Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane bamA - - ko:K07277 - - - - ko00000,ko02000,ko03029 1.B.33 - - Bac_surface_Ag,POTRA k59_823555_1 384765.SIAM614_17164 1.07e-14 72.8 COG4664@1|root,COG4664@2|Bacteria,1R4MZ@1224|Proteobacteria,2TQNR@28211|Alphaproteobacteria 28211|Alphaproteobacteria Q TRAP-type mannitol chloroaromatic compound transport system large permease component - - - - - - - - - - - - DctM k59_823555_2 1123247.AUIJ01000001_gene1730 3.95e-59 197.0 COG4665@1|root,COG4665@2|Bacteria,1QZG7@1224|Proteobacteria,2U0WE@28211|Alphaproteobacteria 28211|Alphaproteobacteria Q Tripartite ATP-independent periplasmic transporters, DctQ component - - - - - - - - - - - - DctQ k59_91810_1 1385514.N782_03295 4.81e-28 112.0 COG1360@1|root,COG1360@2|Bacteria,1V8KE@1239|Firmicutes,4H9MD@91061|Bacilli,2Y8U0@289201|Pontibacillus 91061|Bacilli N Flagellar motor protein MotS ytxE - - ko:K02557 ko02030,ko02040,map02030,map02040 - - - ko00000,ko00001,ko02000,ko02035 1.A.30.1 - - MotB_plug,OmpA k59_823566_1 926559.JoomaDRAFT_0292 3.15e-80 247.0 COG1638@1|root,COG1638@2|Bacteria,4NGV4@976|Bacteroidetes,1HZ02@117743|Flavobacteriia 976|Bacteroidetes G Bacterial extracellular solute-binding protein, family 7 - - - - - - - - - - - - DctP k59_823566_2 1380600.AUYN01000001_gene2839 1.12e-47 158.0 COG0800@1|root,COG0800@2|Bacteria,4NEFY@976|Bacteroidetes,1HYMQ@117743|Flavobacteriia 976|Bacteroidetes G Aldolase eda - 4.1.2.14,4.1.3.42 ko:K01625 ko00030,ko00630,ko01100,ko01120,ko01200,map00030,map00630,map01100,map01120,map01200 M00008,M00061,M00308,M00631 R00470,R05605 RC00307,RC00308,RC00435 ko00000,ko00001,ko00002,ko01000 - - - Aldolase k59_35907_1 393283.XP_007837632.1 0.000837 48.1 COG0666@1|root,KOG4177@2759|Eukaryota,39XHE@33154|Opisthokonta,3NY2D@4751|Fungi,3QTT7@4890|Ascomycota,218DJ@147550|Sordariomycetes 4751|Fungi M Ankyrin repeat - - - ko:K21440 - - - - ko00000,ko04131 - - - Ank_2,Ank_4 k59_319042_1 1121904.ARBP01000006_gene3811 1.59e-10 60.8 COG0192@1|root,COG0192@2|Bacteria,4NG7Y@976|Bacteroidetes,47JW7@768503|Cytophagia 976|Bacteroidetes H Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme metK GO:0003674,GO:0003824,GO:0004478,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016740,GO:0016765,GO:0044424,GO:0044444,GO:0044464 2.5.1.6 ko:K00789 ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230 M00034,M00035,M00368,M00609 R00177,R04771 RC00021,RC01211 ko00000,ko00001,ko00002,ko01000 - - - S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N k59_260844_1 1122137.AQXF01000003_gene2180 6.25e-234 650.0 COG1157@1|root,COG1157@2|Bacteria,1MUH6@1224|Proteobacteria,2TRXU@28211|Alphaproteobacteria 28211|Alphaproteobacteria NU COG1157 Flagellar biosynthesis type III secretory pathway ATPase fliI - 3.6.3.14 ko:K02412 ko02040,map02040 - - - ko00000,ko00001,ko01000,ko02035,ko02044 3.A.6.2,3.A.6.3 - - ATP-synt_ab,ATP-synt_ab_N k59_260844_2 1279038.KB907338_gene825 4.1e-05 46.2 2A16B@1|root,30PCB@2|Bacteria,1Q29I@1224|Proteobacteria,2V9PI@28211|Alphaproteobacteria,2JU5S@204441|Rhodospirillales 204441|Rhodospirillales - - - - - - - - - - - - - - FliJ k59_36767_1 1144305.PMI02_01615 3.75e-35 124.0 COG2197@1|root,COG2197@2|Bacteria,1QWB3@1224|Proteobacteria,2UDC1@28211|Alphaproteobacteria,2KB6T@204457|Sphingomonadales 204457|Sphingomonadales KT cheY-homologous receiver domain - - - - - - - - - - - - Response_reg k59_36767_2 158500.BV97_03451 2.93e-49 169.0 COG4251@1|root,COG4251@2|Bacteria,1NSQ1@1224|Proteobacteria,2TSPY@28211|Alphaproteobacteria,2K9I0@204457|Sphingomonadales 204457|Sphingomonadales T PAS domain - - - - - - - - - - - - HATPase_c,HisKA,PAS,PAS_8,PAS_9 k59_1220980_1 1123258.AQXZ01000019_gene3340 4.51e-24 108.0 COG1053@1|root,COG1413@1|root,COG1053@2|Bacteria,COG1413@2|Bacteria,2GPN8@201174|Actinobacteria,4FWFU@85025|Nocardiaceae 201174|Actinobacteria C HEAT repeats - - 1.3.5.1,1.3.5.4 ko:K00239 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134 M00009,M00011,M00149,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 - - - Cohesin_HEAT,FAD_binding_2,HEAT_2,Succ_DH_flav_C k59_1671181_1 316407.85676410 4.39e-77 238.0 COG0859@1|root,COG0859@2|Bacteria,1MYZA@1224|Proteobacteria,1RR6K@1236|Gammaproteobacteria,3XMTY@561|Escherichia 1236|Gammaproteobacteria M Catalyzes heptose transfer to the lipopolysaccharide core. It transfers a heptose, called heptose(III), to the heptose(II) of the inner core rfaQ GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0008713,GO:0008920,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016740,GO:0016757,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0046401,GO:0071704,GO:0071967,GO:1901135,GO:1901137,GO:1901576,GO:1903509 - ko:K02849 ko00540,ko01100,map00540,map01100 M00080 - - ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT9 iAF1260.b3632,iBWG_1329.BWG_3323,iECDH10B_1368.ECDH10B_3814,iJO1366.b3632,iSSON_1240.SSON_3775,iY75_1357.Y75_RS18975 Glyco_transf_9 k59_1506071_1 404589.Anae109_0680 3.02e-12 65.5 COG4969@1|root,COG4969@2|Bacteria 2|Bacteria NU cell adhesion - - - ko:K02650 ko02020,map02020 - - - ko00000,ko00001,ko02035,ko02044 3.A.15.2 - - N_methyl,Pilin k59_1506071_2 1122194.AUHU01000018_gene3448 0.000695 41.6 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,4642R@72275|Alteromonadaceae 1236|Gammaproteobacteria T COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains pilR - - ko:K02481,ko:K02667 ko02020,map02020 M00501 - - ko00000,ko00001,ko00002,ko02022,ko02035 - - - HTH_8,Response_reg,Sigma54_activat k59_824457_1 330214.NIDE1010 1.1e-52 176.0 COG0809@1|root,COG0809@2|Bacteria,3J0HB@40117|Nitrospirae 40117|Nitrospirae J Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) queA GO:0002097,GO:0002099,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016853,GO:0018130,GO:0019438,GO:0034404,GO:0034470,GO:0034641,GO:0034654,GO:0034660,GO:0042455,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0051075,GO:0055086,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.4.99.17 ko:K07568 - - - - ko00000,ko01000,ko03016 - - - Queuosine_synth k59_1331131_1 1121921.KB898706_gene3188 1.34e-95 285.0 COG2878@1|root,COG2878@2|Bacteria,1MUWU@1224|Proteobacteria,1RNSJ@1236|Gammaproteobacteria,2PMP0@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria C Putative Fe-S cluster rnfB GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0055114 - ko:K03616 - - - - ko00000 - - - FeS,Fer4_21 k59_1331131_2 1323663.AROI01000037_gene1290 2.63e-12 66.2 COG3064@1|root,COG4656@1|root,COG3064@2|Bacteria,COG4656@2|Bacteria,1QTUI@1224|Proteobacteria,1RMIM@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Part of a membrane complex involved in electron transport rnfC GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0055114 - ko:K03615 - - - - ko00000 - - - Complex1_51K,Fer4_10,Fer4_7,Fer4_8,RnfC_N,SLBB k59_714371_1 555793.WSK_0803 5.78e-98 291.0 COG0596@1|root,COG0596@2|Bacteria,1RFX1@1224|Proteobacteria,2U79Q@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Alpha beta hydrolase - - - - - - - - - - - - Abhydrolase_1 k59_427857_1 1229909.NSED_08960 2.04e-53 178.0 COG0803@1|root,arCOG01005@2157|Archaea,41T29@651137|Thaumarchaeota 651137|Thaumarchaeota P Periplasmic solute binding protein - - - ko:K09815 ko02010,map02010 M00242 - - ko00000,ko00001,ko00002,ko02000 3.A.1.15.3,3.A.1.15.5 - - ZnuA k59_1164661_1 436308.Nmar_1725 2.64e-90 274.0 COG0301@1|root,arCOG00038@2157|Archaea,41T1A@651137|Thaumarchaeota 651137|Thaumarchaeota H Thiamine biosynthesis protein (ThiI) - - - - - - - - - - - - DUF814,ThiI k59_1164661_3 1229909.NSED_09195 6.88e-47 165.0 COG1782@1|root,arCOG00543@2157|Archaea,41T05@651137|Thaumarchaeota 651137|Thaumarchaeota S RNA-metabolising metallo-beta-lactamase - - - ko:K07041 - - - - ko00000 - - - Beta-Casp,KH_7,Lactamase_B_6,RMMBL k59_538396_1 1144307.PMI04_01050 3.95e-40 139.0 COG4319@1|root,COG4319@2|Bacteria,1R2NE@1224|Proteobacteria,2UWNA@28211|Alphaproteobacteria,2K8A2@204457|Sphingomonadales 204457|Sphingomonadales S SnoaL-like domain - - - - - - - - - - - - SnoaL_4 k59_427864_2 76114.ebA1021 1.73e-53 187.0 COG0013@1|root,COG0013@2|Bacteria,1MU9A@1224|Proteobacteria,2VH6Z@28216|Betaproteobacteria,2KVJ1@206389|Rhodocyclales 206389|Rhodocyclales J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain alaS - 6.1.1.7 ko:K01872 ko00970,map00970 M00359,M00360 R03038 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DHHA1,tRNA-synt_2c,tRNA_SAD k59_765725_1 1122137.AQXF01000002_gene426 2.05e-93 290.0 COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2U0WI@28211|Alphaproteobacteria 28211|Alphaproteobacteria IQ COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II - - - - - - - - - - - - AMP-binding,AMP-binding_C k59_376444_1 278957.ABEA03000195_gene525 1.57e-18 89.7 COG0111@1|root,COG0111@2|Bacteria,46S96@74201|Verrucomicrobia,3K7KV@414999|Opitutae 2|Bacteria EH D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain - - - - - - - - - - - - 2-Hacid_dh_C k59_1164674_1 436308.Nmar_0651 2.17e-121 381.0 COG1196@1|root,arCOG00371@2157|Archaea,41SDS@651137|Thaumarchaeota 651137|Thaumarchaeota D SMC proteins Flexible Hinge Domain - - - ko:K03529 - - - - ko00000,ko03036 - - - SMC_N,SMC_hinge k59_538410_2 1125971.ASJB01000064_gene6648 1.4e-11 66.2 COG0601@1|root,COG0601@2|Bacteria,2GM72@201174|Actinobacteria,4DZ95@85010|Pseudonocardiales 201174|Actinobacteria P ABC-type dipeptide oligopeptide nickel transport - - - ko:K02033 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1 k59_261739_1 452637.Oter_1396 5.64e-91 280.0 COG1139@1|root,COG1139@2|Bacteria,46SBN@74201|Verrucomicrobia,3K7N0@414999|Opitutae 414999|Opitutae C Domain of unknown function (DUF3390) - - - ko:K18929 - - - - ko00000 - - - DUF3390,Fer4_8,LUD_dom k59_1444177_2 926569.ANT_30020 3.13e-38 130.0 COG1662@1|root,COG1662@2|Bacteria 2|Bacteria L PFAM IS1 transposase - - - ko:K07480 - - - - ko00000 - - - DDE_Tnp_IS1 k59_146682_1 160488.PP_5213 8.26e-35 130.0 COG0043@1|root,COG0043@2|Bacteria,1MU62@1224|Proteobacteria,1RNH8@1236|Gammaproteobacteria,1YWHF@136845|Pseudomonas putida group 1236|Gammaproteobacteria H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol, an intermediate step in ubiquinone biosynthesis ubiD GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0008694,GO:0009058,GO:0009108,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0042180,GO:0042181,GO:0042802,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901661,GO:1901663 4.1.1.98 ko:K03182 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00117 R04985,R04986 RC00391 ko00000,ko00001,ko00002,ko01000 - - iECO111_1330.ECO111_4669 UbiD k59_146682_2 1033806.HTIA_0597 1.87e-05 48.5 COG1192@1|root,arCOG00586@2157|Archaea,2XV5C@28890|Euryarchaeota,23RZK@183963|Halobacteria 183963|Halobacteria D COG1192 ATPases involved in chromosome partitioning - - - ko:K03496 - - - - ko00000,ko03036,ko04812 - - - AAA_31 k59_376476_1 656519.Halsa_0984 1.88e-66 219.0 COG4909@1|root,COG4909@2|Bacteria,1TPU7@1239|Firmicutes,24AFR@186801|Clostridia 186801|Clostridia Q Dehydratase large subunit dhaB - 4.2.1.28,4.2.1.30 ko:K01699,ko:K06120 ko00561,ko00640,map00561,map00640 - R01047,R02376 RC00429,RC00707 ko00000,ko00001,ko01000 - - - Dehydratase_LU k59_1506122_1 1242864.D187_002077 2.35e-159 497.0 COG0514@1|root,COG0550@1|root,COG0514@2|Bacteria,COG0550@2|Bacteria,1MUFZ@1224|Proteobacteria,42NQG@68525|delta/epsilon subdivisions,2WJXC@28221|Deltaproteobacteria,2YU8A@29|Myxococcales 28221|Deltaproteobacteria L ATP-dependent DNA helicase RecQ topB - 5.99.1.2 ko:K03169 - - - - ko00000,ko01000,ko03032 - - - DEAD,HRDC,Helicase_C,RecQ_Zn_bind,Topoisom_bac,Toprim,Toprim_Crpt,zf-C4_Topoisom k59_204101_1 344747.PM8797T_03740 9.19e-34 125.0 2EMAF@1|root,33EZG@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_714436_1 1415778.JQMM01000001_gene245 5.55e-55 175.0 2C46F@1|root,32SRD@2|Bacteria,1N540@1224|Proteobacteria,1S8P6@1236|Gammaproteobacteria,1J6QG@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_714436_2 765912.Thimo_1297 1.35e-14 73.2 COG0119@1|root,COG0119@2|Bacteria,1R7YB@1224|Proteobacteria,1RQB8@1236|Gammaproteobacteria,1WX74@135613|Chromatiales 135613|Chromatiales E Belongs to the alpha-IPM synthase homocitrate synthase family - - 2.3.1.182 ko:K09011 ko00290,ko00660,ko01100,ko01210,ko01230,map00290,map00660,map01100,map01210,map01230 M00535 R07399 RC00004,RC01205 br01601,ko00000,ko00001,ko00002,ko01000 - - - HMGL-like,LeuA_dimer k59_765760_1 450851.PHZ_c0726 9.45e-69 222.0 COG2267@1|root,COG2267@2|Bacteria,1QDFI@1224|Proteobacteria,2U244@28211|Alphaproteobacteria,2KIAB@204458|Caulobacterales 204458|Caulobacterales I Protein of unknown function (DUF3089) - - - - - - - - - - - - DUF3089 k59_714450_1 158500.BV97_00666 2.12e-127 384.0 COG0046@1|root,COG0046@2|Bacteria,1MYN4@1224|Proteobacteria,2TRGM@28211|Alphaproteobacteria,2K25A@204457|Sphingomonadales 204457|Sphingomonadales F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL purL - 6.3.5.3 ko:K01952 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04463 RC00010,RC01160 ko00000,ko00001,ko00002,ko01000 - - - AIRS,AIRS_C k59_1393150_1 158500.BV97_04730 4.39e-12 68.2 COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TR8X@28211|Alphaproteobacteria,2K0ZS@204457|Sphingomonadales 204457|Sphingomonadales T nitrogen fixation sensor protein fixL - - 2.7.13.3 ko:K14986 ko02020,map02020 M00524 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA,PAS k59_1563529_1 1122137.AQXF01000002_gene332 3.56e-43 156.0 COG4421@1|root,COG4421@2|Bacteria,1R5RK@1224|Proteobacteria,2U181@28211|Alphaproteobacteria 28211|Alphaproteobacteria G COG4421 Capsular polysaccharide biosynthesis protein - - - - - - - - - - - - DUF563,Methyltransf_21 k59_1274273_1 861450.HMPREF0080_00476 1.95e-41 143.0 COG0041@1|root,COG0041@2|Bacteria,1V1MV@1239|Firmicutes,4H4GQ@909932|Negativicutes 909932|Negativicutes F Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) purE - 5.4.99.18 ko:K01588 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R07405 RC01947 ko00000,ko00001,ko00002,ko01000 - - - AIRC k59_1164738_1 1038859.AXAU01000016_gene6881 1.28e-08 55.5 COG0796@1|root,COG0796@2|Bacteria,1NAI2@1224|Proteobacteria,2TSR7@28211|Alphaproteobacteria,3JRJY@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria M Provides the (R)-glutamate required for cell wall biosynthesis murI - 5.1.1.3 ko:K01776 ko00471,ko01100,map00471,map01100 - R00260 RC00302 ko00000,ko00001,ko01000,ko01011 - - - Asp_Glu_race k59_884946_1 1030157.AFMP01000014_gene3367 8.69e-84 263.0 COG2072@1|root,COG2072@2|Bacteria,1MUQH@1224|Proteobacteria,2TRG4@28211|Alphaproteobacteria,2JZUE@204457|Sphingomonadales 204457|Sphingomonadales P Flavin-binding monooxygenase-like - - - - - - - - - - - - FMO-like,K_oxygenase,Pyr_redox_3 k59_204142_1 1122137.AQXF01000001_gene3261 6.4e-153 456.0 COG1629@1|root,COG1629@2|Bacteria,COG4771@2|Bacteria,1MWKN@1224|Proteobacteria,2VFCK@28211|Alphaproteobacteria 28211|Alphaproteobacteria P TonB dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_1506169_1 1121033.AUCF01000015_gene1515 2.71e-18 87.4 COG2207@1|root,COG2207@2|Bacteria,1Q1II@1224|Proteobacteria,2TUE0@28211|Alphaproteobacteria,2JTDC@204441|Rhodospirillales 204441|Rhodospirillales K COG2207 AraC-type DNA-binding domain-containing proteins - - - - - - - - - - - - AraC_binding_2,HTH_18 k59_942628_1 1163617.SCD_n00294 3e-21 86.3 COG0346@1|root,COG0346@2|Bacteria,1N116@1224|Proteobacteria,2VRA3@28216|Betaproteobacteria 28216|Betaproteobacteria E PFAM Glyoxalase bleomycin resistance protein dioxygenase - - - ko:K07032 - - - - ko00000 - - - Glyoxalase k59_942628_2 1121935.AQXX01000116_gene5183 4.14e-59 182.0 COG3461@1|root,COG3461@2|Bacteria,1MZZN@1224|Proteobacteria,1S688@1236|Gammaproteobacteria,1XPP3@135619|Oceanospirillales 135619|Oceanospirillales S Evidence 4 Homologs of previously reported genes of - - - ko:K09700 - - - - ko00000 - - - - k59_1735753_1 713586.KB900536_gene1377 9.82e-121 365.0 COG0770@1|root,COG0770@2|Bacteria,1QTSF@1224|Proteobacteria,1RMGD@1236|Gammaproteobacteria,1WWTC@135613|Chromatiales 135613|Chromatiales M Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein murF - 6.3.2.10 ko:K01929 ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502 - R04573,R04617 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_1735753_2 1127673.GLIP_2963 3.54e-06 48.1 COG0472@1|root,COG0472@2|Bacteria,1MUTK@1224|Proteobacteria,1RNIG@1236|Gammaproteobacteria,465NF@72275|Alteromonadaceae 1236|Gammaproteobacteria M First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan mraY GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008963,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016780,GO:0030203,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 2.7.8.13 ko:K01000 ko00550,ko01100,ko01502,map00550,map01100,map01502 - R05629,R05630 RC00002,RC02753 ko00000,ko00001,ko01000,ko01011 9.B.146 - iEC042_1314.EC042_0088,iECABU_c1320.ECABU_c00920,iECED1_1282.ECED1_0088,iECH74115_1262.ECH74115_0095,iECSP_1301.ECSP_0090,iECs_1301.ECs0091,iG2583_1286.G2583_0091,iSDY_1059.SDY_0117,iZ_1308.Z0097,ic_1306.c0105 Glycos_transf_4,MraY_sig1 k59_326828_1 686578.AFFX01000004_gene3809 1.1e-28 116.0 COG0475@1|root,COG1226@1|root,COG0475@2|Bacteria,COG1226@2|Bacteria,1MV34@1224|Proteobacteria,1RNVR@1236|Gammaproteobacteria 1236|Gammaproteobacteria P Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family kefB - - ko:K03455,ko:K11745,ko:K11747 - - - - ko00000,ko02000 2.A.37,2.A.37.1.1,2.A.37.1.2 - - Na_H_Exchanger,TrkA_N k59_1171580_1 1379270.AUXF01000006_gene133 3.9e-82 254.0 COG1077@1|root,COG1077@2|Bacteria,1ZT9B@142182|Gemmatimonadetes 142182|Gemmatimonadetes D Hsp70 protein - - - ko:K03569 - - - - ko00000,ko02048,ko03036,ko04812 1.A.33.1,9.B.157.1 - - MreB_Mbl k59_1512947_1 509190.Cseg_3364 1.58e-24 107.0 COG1629@1|root,COG1629@2|Bacteria,1QVFQ@1224|Proteobacteria,2TWDY@28211|Alphaproteobacteria,2KH4Y@204458|Caulobacterales 204458|Caulobacterales P Carboxypeptidase regulatory-like domain - - - - - - - - - - - - CarboxypepD_reg,Plug,TonB_dep_Rec k59_1112641_2 2074.JNYD01000007_gene2179 1.52e-05 47.0 COG1028@1|root,COG1028@2|Bacteria,2GJU1@201174|Actinobacteria,4DYZY@85010|Pseudonocardiales 201174|Actinobacteria IQ Enoyl-(Acyl carrier protein) reductase - - 1.1.1.69 ko:K00046 - - - - ko00000,ko01000 - - - adh_short_C2 k59_1171582_1 1304275.C41B8_14360 1.03e-06 51.2 COG2377@1|root,COG2377@2|Bacteria,1MV4E@1224|Proteobacteria,1RNTZ@1236|Gammaproteobacteria 1236|Gammaproteobacteria F Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling anmK GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0044237 2.7.1.170 ko:K09001 - - - - ko00000,ko01000 - - iECABU_c1320.ECABU_c18930,iECED1_1282.ECED1_1841,ic_1306.c2032 AnmK k59_1171582_2 1127673.GLIP_2431 2.93e-24 103.0 COG0739@1|root,COG0739@2|Bacteria,1MVTF@1224|Proteobacteria,1RM7S@1236|Gammaproteobacteria,4640S@72275|Alteromonadaceae 1236|Gammaproteobacteria M COG0739 Membrane proteins related to metalloendopeptidases yebA - - - - - - - - - - - OapA,OapA_N,Peptidase_M23 k59_43422_1 1122225.AULQ01000005_gene2431 1.27e-111 359.0 COG1747@1|root,COG1747@2|Bacteria,4NEB8@976|Bacteroidetes,1HXVQ@117743|Flavobacteriia 976|Bacteroidetes S SprA protein sprA - - - - - - - - - - - SprA_N k59_722570_2 1151127.KB906334_gene4226 8.54e-40 137.0 COG2867@1|root,COG2867@2|Bacteria,1RGUH@1224|Proteobacteria,1S61C@1236|Gammaproteobacteria,1YQBG@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria I Polyketide cyclase / dehydrase and lipid transport ratA GO:0003674,GO:0005488,GO:0006417,GO:0006446,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0017148,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0034248,GO:0034249,GO:0043021,GO:0043023,GO:0044877,GO:0045947,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0080090,GO:2000112,GO:2000113 - - - - - - - - - - Polyketide_cyc k59_546461_1 1380600.AUYN01000003_gene109 2.06e-54 175.0 COG0457@1|root,COG0457@2|Bacteria,4NRIH@976|Bacteroidetes,1I1SZ@117743|Flavobacteriia 976|Bacteroidetes S Protein of unknown function (DUF2911) - - - - - - - - - - - - DUF2911 k59_1113315_1 573413.Spirs_2799 1.08e-13 74.3 2DPIM@1|root,33285@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - Terminase_6C k59_773306_1 247633.GP2143_16171 3.15e-61 209.0 COG1200@1|root,COG1200@2|Bacteria,1MWN2@1224|Proteobacteria,1RMMQ@1236|Gammaproteobacteria,1J4VK@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) recG GO:0003674,GO:0003678,GO:0003724,GO:0003824,GO:0004003,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006807,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0008186,GO:0009314,GO:0009379,GO:0009628,GO:0009987,GO:0010501,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0032991,GO:0033202,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0051276,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:0140098,GO:1901360,GO:1902494 3.6.4.12 ko:K03655 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,Helicase_C,RecG_wedge k59_384124_1 1121459.AQXE01000013_gene2186 1.13e-31 119.0 COG3926@1|root,COG3926@2|Bacteria,1MVXW@1224|Proteobacteria,42X4V@68525|delta/epsilon subdivisions,2WSN4@28221|Deltaproteobacteria,2MD5R@213115|Desulfovibrionales 28221|Deltaproteobacteria S Predicted Peptidoglycan domain - - - - - - - - - - - - Glyco_hydro_108,PG_binding_3 k59_1788667_1 1288494.EBAPG3_8930 8.45e-90 271.0 COG4535@1|root,COG4535@2|Bacteria,1QTU8@1224|Proteobacteria,2VIU8@28216|Betaproteobacteria,372B3@32003|Nitrosomonadales 28216|Betaproteobacteria P Transporter associated domain corC - - ko:K06189 - - - - ko00000,ko02000 9.A.40.1.2 - - CBS,CorC_HlyC k59_1571189_1 1163617.SCD_n02927 3.62e-37 132.0 COG0351@1|root,COG0351@2|Bacteria,1MU9J@1224|Proteobacteria,2VKD2@28216|Betaproteobacteria 28216|Betaproteobacteria H Phosphomethylpyrimidine kinase thiD - 2.7.1.49,2.7.4.7 ko:K00941 ko00730,ko01100,map00730,map01100 M00127 R03471,R04509 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - Phos_pyr_kin k59_1571189_2 228410.NE1426 1.74e-34 118.0 COG1773@1|root,COG1773@2|Bacteria,1N731@1224|Proteobacteria,2VVP4@28216|Betaproteobacteria,373M4@32003|Nitrosomonadales 28216|Betaproteobacteria C PFAM Rubredoxin-type Fe(Cys)4 protein rubA - - - - - - - - - - - Rubredoxin k59_99953_1 1229909.NSED_07110 1.32e-89 274.0 COG0477@1|root,arCOG00130@2157|Archaea 2157|Archaea EGP Major facilitator superfamily - - - ko:K08153 - M00717 - - ko00000,ko00002,ko02000 2.A.1.2.8 - - MFS_1,PUCC k59_1452039_1 1033740.CAEW01000014_gene3012 7.94e-33 127.0 COG1003@1|root,COG1003@2|Bacteria,1TPK9@1239|Firmicutes,4HB80@91061|Bacilli,26DQY@186818|Planococcaceae 91061|Bacilli E The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor gcvPB - 1.4.4.2 ko:K00283 ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200 - R01221,R03425 RC00022,RC00929,RC02834,RC02880 ko00000,ko00001,ko01000 - - - GDC-P k59_1452039_2 1121423.JONT01000001_gene2099 1.64e-118 357.0 COG0403@1|root,COG0403@2|Bacteria,1TQGG@1239|Firmicutes,2492A@186801|Clostridia,2608E@186807|Peptococcaceae 186801|Clostridia E The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor gcvPA - 1.4.4.2 ko:K00282 ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200 - R01221,R03425 RC00022,RC00929,RC02834,RC02880 ko00000,ko00001,ko01000 - - - GDC-P k59_999397_1 316407.1799963 2.69e-107 317.0 COG1172@1|root,COG1172@2|Bacteria,1PSTG@1224|Proteobacteria,1RSQZ@1236|Gammaproteobacteria,3XQ7B@561|Escherichia 1236|Gammaproteobacteria G Probably part of the binding-protein-dependent transport system YphDEF. Probably responsible for the translocation of the substrate across the membrane yphD GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0008643,GO:0015144,GO:0015145,GO:0015749,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034219,GO:0044425,GO:0044459,GO:0044464,GO:0051119,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944 - ko:K02057 - M00221 - - ko00000,ko00002,ko02000 3.A.1.2 - - BPD_transp_2 k59_999397_2 316407.1799964 5.98e-39 141.0 COG1129@1|root,COG1129@2|Bacteria,1MU22@1224|Proteobacteria,1S1ND@1236|Gammaproteobacteria,3XNWJ@561|Escherichia 1236|Gammaproteobacteria P ABC transporter, ATP-binding protein yphE - 3.6.3.17 ko:K02056 - M00221 - - ko00000,ko00002,ko01000,ko02000 3.A.1.2 - - ABC_tran k59_99956_1 1247726.MIM_c09780 1.61e-41 147.0 COG1181@1|root,COG1181@2|Bacteria,1MUTB@1224|Proteobacteria,2VHIW@28216|Betaproteobacteria,3T1X0@506|Alcaligenaceae 28216|Betaproteobacteria F Belongs to the D-alanine--D-alanine ligase family ddl - 6.3.2.4 ko:K01921 ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502 - R01150 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Dala_Dala_lig_C,Dala_Dala_lig_N k59_99956_2 498761.HM1_2061 9.95e-18 82.0 COG0812@1|root,COG0812@2|Bacteria,1TP3W@1239|Firmicutes,247IU@186801|Clostridia 186801|Clostridia M Cell wall formation murB - 1.3.1.98 ko:K00075 ko00520,ko00550,ko01100,map00520,map00550,map01100 - R03191,R03192 RC02639 ko00000,ko00001,ko01000,ko01011 - - - FAD_binding_4,MurB_C k59_1172377_1 83219.PM02_17300 1.06e-53 179.0 COG1946@1|root,COG1946@2|Bacteria,1MV9R@1224|Proteobacteria,2TRFD@28211|Alphaproteobacteria,3ZVM1@60136|Sulfitobacter 28211|Alphaproteobacteria I Acyl-CoA thioesterase tesB GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006163,GO:0006629,GO:0006631,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009117,GO:0009150,GO:0009259,GO:0009987,GO:0016042,GO:0016054,GO:0016289,GO:0016787,GO:0016788,GO:0016790,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0033865,GO:0033875,GO:0034032,GO:0034641,GO:0035383,GO:0042802,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0046483,GO:0047617,GO:0051186,GO:0055086,GO:0071704,GO:0072329,GO:0072521,GO:1901135,GO:1901360,GO:1901564,GO:1901575 - ko:K10805 ko01040,map01040 - - - ko00000,ko00001,ko01000,ko01004 - - - 4HBT_3 k59_1172379_1 1122179.KB890426_gene3975 7.66e-67 223.0 COG4670@1|root,COG4670@2|Bacteria,4NIRA@976|Bacteroidetes 976|Bacteroidetes I Coenzyme A transferase - - - - - - - - - - - - CoA_trans k59_722602_1 1178825.ALIH01000001_gene2586 3.13e-53 184.0 COG4775@1|root,COG4775@2|Bacteria,4NF35@976|Bacteroidetes,1HZII@117743|Flavobacteriia 976|Bacteroidetes M Outer membrane protein protective antigen OMA87 - - - - - - - - - - - - Bac_surface_Ag,POTRA,ShlB k59_1623756_2 1121035.AUCH01000003_gene1395 1.23e-10 58.2 28UD1@1|root,2ZGI9@2|Bacteria,1PBC7@1224|Proteobacteria,2W6D3@28216|Betaproteobacteria,2KZFV@206389|Rhodocyclales 206389|Rhodocyclales - - - - - - - - - - - - - - - k59_435313_1 556268.OFAG_00651 2.18e-33 129.0 COG0845@1|root,COG0845@2|Bacteria,1MU78@1224|Proteobacteria,2VINC@28216|Betaproteobacteria,47760@75682|Oxalobacteraceae 28216|Betaproteobacteria M Barrel-sandwich domain of CusB or HlyD membrane-fusion - - - ko:K03585 ko01501,ko01503,map01501,map01503 M00646,M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000,ko03036 2.A.6.2,8.A.1.6 - - HlyD_D23 k59_435313_2 314231.FP2506_09646 1.28e-15 76.3 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2TQT0@28211|Alphaproteobacteria,2PKF7@255475|Aurantimonadaceae 28211|Alphaproteobacteria U AcrB/AcrD/AcrF family - - - ko:K18138,ko:K18902 ko01501,ko01503,map01501,map01503 M00647,M00698,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000 2.A.6.2 - - ACR_tran k59_44061_2 1385517.N800_12720 5.12e-56 178.0 COG3791@1|root,COG3791@2|Bacteria,1N031@1224|Proteobacteria,1S69Q@1236|Gammaproteobacteria,1X8MY@135614|Xanthomonadales 135614|Xanthomonadales S Glutathione-dependent formaldehyde-activating enzyme - - - - - - - - - - - - GFA k59_44061_3 747.DR93_2008 5.16e-07 50.1 COG0692@1|root,COG0692@2|Bacteria,1MV80@1224|Proteobacteria,1RPDH@1236|Gammaproteobacteria,1Y793@135625|Pasteurellales 135625|Pasteurellales L Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine ung GO:0003674,GO:0003824,GO:0004844,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006285,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097506,GO:0097510,GO:0140097,GO:1901360 3.2.2.27 ko:K03648 ko03410,ko05340,map03410,map05340 - - - ko00000,ko00001,ko01000,ko03400 - - - UDG k59_211700_1 1229780.BN381_300027 1.17e-80 266.0 COG0433@1|root,COG0433@2|Bacteria 2|Bacteria S helicase activity - - - - - - - - - - - - DUF853,DUF87 k59_1060526_1 1469557.JSWF01000035_gene958 2.35e-177 561.0 COG3291@1|root,COG3291@2|Bacteria,4NDZQ@976|Bacteroidetes,1HX5A@117743|Flavobacteriia 976|Bacteroidetes M C-terminal domain of CHU protein family - - - - - - - - - - - - CHU_C,CUB,HYR,PKD,SprB k59_609165_1 436308.Nmar_1310 2.61e-86 259.0 COG0518@1|root,arCOG00090@2157|Archaea,41T3Z@651137|Thaumarchaeota 651137|Thaumarchaeota F glutamine amidotransferase - - - - - - - - - - - - GATase k59_384149_1 543526.Htur_0136 6.56e-247 707.0 COG2217@1|root,arCOG01576@2157|Archaea,2XT3T@28890|Euryarchaeota,23S6X@183963|Halobacteria 183963|Halobacteria P copper-translocating P-type ATPase - - 3.6.3.4 ko:K01533 - - R00086 RC00002 ko00000,ko01000 3.A.3.5 - - E1-E2_ATPase,Hydrolase k59_1228259_2 207954.MED92_09241 6.53e-54 176.0 COG3067@1|root,COG3067@2|Bacteria,1MV0F@1224|Proteobacteria,1RPE3@1236|Gammaproteobacteria,1XI7E@135619|Oceanospirillales 135619|Oceanospirillales P Na( ) H( ) antiporter that extrudes sodium in exchange for external protons nhaB - - ko:K03314 - - - - ko00000,ko02000 2.A.34.1 - - NhaB k59_609173_1 937777.Deipe_0025 1.79e-51 182.0 COG3525@1|root,COG3525@2|Bacteria 2|Bacteria G beta-N-acetylhexosaminidase activity hyl GO:0003674,GO:0003824,GO:0004553,GO:0004563,GO:0005488,GO:0005515,GO:0005975,GO:0006464,GO:0006517,GO:0006807,GO:0008150,GO:0008152,GO:0009100,GO:0009987,GO:0015929,GO:0016231,GO:0016787,GO:0016798,GO:0019538,GO:0030246,GO:0036211,GO:0042802,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0071704,GO:1901135,GO:1901564 2.3.1.48,3.2.1.169,3.2.1.35 ko:K01197,ko:K15719 ko00531,ko01100,ko04931,map00531,map01100,map04931 M00076,M00077 R07824,R07825,R09672,R09673,R10905 RC00059,RC00397,RC00451,RC00746 ko00000,ko00001,ko00002,ko00536,ko00537,ko01000,ko02042 - GH84 - F5_F8_type_C,Glyco_hydro_20b,NAGidase k59_773348_1 1234595.C725_2330 2.82e-16 76.3 COG0090@1|root,COG0090@2|Bacteria,1MVTD@1224|Proteobacteria,2TTKD@28211|Alphaproteobacteria,4BP8Y@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria J One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity rplB GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02886 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L2,Ribosomal_L2_C k59_773348_2 1122137.AQXF01000006_gene973 1.27e-54 171.0 COG0089@1|root,COG0089@2|Bacteria,1MZXX@1224|Proteobacteria,2UBQ1@28211|Alphaproteobacteria 28211|Alphaproteobacteria J One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome rplW GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02892 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L23 k59_773348_3 935261.JAGL01000003_gene3190 1.39e-17 79.0 COG0088@1|root,COG0088@2|Bacteria,1MXPF@1224|Proteobacteria,2TRUT@28211|Alphaproteobacteria,43H9Y@69277|Phyllobacteriaceae 28211|Alphaproteobacteria J Forms part of the polypeptide exit tunnel rplD GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02926 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L4 k59_1401162_1 504487.JCM19302_1878 3.69e-102 301.0 COG0568@1|root,COG0568@2|Bacteria,4NEBF@976|Bacteroidetes,1HWSN@117743|Flavobacteriia 976|Bacteroidetes K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released rpoD - - ko:K03086 - - - - ko00000,ko03021 - - - Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4 k59_1571226_1 1298593.TOL_1870 1.76e-09 57.4 COG0215@1|root,COG0215@2|Bacteria,1MV8H@1224|Proteobacteria,1RP5K@1236|Gammaproteobacteria,1XH2Z@135619|Oceanospirillales 135619|Oceanospirillales J Belongs to the class-I aminoacyl-tRNA synthetase family cysS - 6.1.1.16 ko:K01883 ko00970,map00970 M00359,M00360 R03650 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DALR_2,tRNA-synt_1e,tRNA-synt_1g k59_1571226_2 1121374.KB891585_gene2303 5.11e-64 213.0 COG0008@1|root,COG0008@2|Bacteria,1MUC8@1224|Proteobacteria,1RQ7G@1236|Gammaproteobacteria 1236|Gammaproteobacteria J Catalyzes a two-step reaction, first charging a glutamine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA glnS GO:0003674,GO:0003824,GO:0004812,GO:0004819,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006425,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.18 ko:K01886 ko00970,ko01100,map00970,map01100 M00359,M00360 R03652 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iECIAI39_1322.ECIAI39_0637 tRNA-synt_1c,tRNA-synt_1c_C k59_1513715_1 77586.LPERR03G01300.1 7.74e-38 140.0 COG3001@1|root,KOG3021@2759|Eukaryota,37MIU@33090|Viridiplantae,3GEFM@35493|Streptophyta,3KS2X@4447|Liliopsida,3I8BU@38820|Poales 35493|Streptophyta G Fructosamine kinase - GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009507,GO:0009536,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044424,GO:0044444,GO:0044464 2.7.1.172 ko:K15523 - - - - ko00000,ko01000 - - - Fructosamin_kin k59_999436_1 1122137.AQXF01000002_gene519 1.56e-125 380.0 COG0480@1|root,COG0480@2|Bacteria,1MU2W@1224|Proteobacteria,2TYVK@28211|Alphaproteobacteria 28211|Alphaproteobacteria J elongation factor G MA20_05220 - - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2 k59_1788751_1 911045.PSE_4992 1.1e-120 353.0 COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,2TREJ@28211|Alphaproteobacteria 28211|Alphaproteobacteria I Catalyzes the formation of 3-methylbut-2-enoyl CoA from 3-methylbutanoyl CoA ivd - 1.3.8.4 ko:K00253 ko00280,ko01100,map00280,map01100 M00036 R04095 RC00246 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_327569_1 1229909.NSED_03915 1.38e-64 209.0 arCOG08742@1|root,arCOG08742@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_546535_2 1322246.BN4_11469 1.53e-05 46.2 COG3437@1|root,COG3437@2|Bacteria,1QUN9@1224|Proteobacteria,42PB6@68525|delta/epsilon subdivisions,2WJJ9@28221|Deltaproteobacteria,2M8RX@213115|Desulfovibrionales 28221|Deltaproteobacteria T SMART Metal-dependent phosphohydrolase, HD region - - - - - - - - - - - - DUF3369,HD,HD_5,Response_reg k59_384183_1 745718.JADT01000008_gene3126 6.6e-121 350.0 COG0090@1|root,COG0090@2|Bacteria,4NE8G@976|Bacteroidetes,1HXDV@117743|Flavobacteriia 976|Bacteroidetes J One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity rplB GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02886 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L2,Ribosomal_L2_C k59_832143_1 436308.Nmar_1577 9.8e-137 401.0 COG0459@1|root,arCOG01257@2157|Archaea,41T11@651137|Thaumarchaeota 651137|Thaumarchaeota O TCP-1/cpn60 chaperonin family - - - ko:K22447 - - - - ko00000,ko03110 - - - Cpn60_TCP1 k59_1338553_2 118797.XP_007471766.1 9.11e-32 124.0 29J1X@1|root,2RS9Y@2759|Eukaryota,3AG7Y@33154|Opisthokonta,3BY7J@33208|Metazoa,3DDMG@33213|Bilateria 33208|Metazoa S Rho termination factor, RNA-binding domain - - - - - - - - - - - - ATP-synt_ab,Rho_N,Rho_RNA_bind k59_1623806_1 760117.JN27_01205 5.73e-75 243.0 COG0303@1|root,COG0746@1|root,COG0303@2|Bacteria,COG0746@2|Bacteria,1MVD5@1224|Proteobacteria,2VH78@28216|Betaproteobacteria,473QZ@75682|Oxalobacteraceae 28216|Betaproteobacteria H Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor moeA2 - 2.10.1.1 ko:K03750 ko00790,ko01100,map00790,map01100 - R09735 RC03462 ko00000,ko00001,ko01000 - - - MoCF_biosynth,MoeA_C,MoeA_N k59_1401197_1 1265313.HRUBRA_01352 2.41e-87 265.0 COG0189@1|root,COG0189@2|Bacteria,1MVUA@1224|Proteobacteria,1RMU0@1236|Gammaproteobacteria,1J4CV@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Belongs to the prokaryotic GSH synthase family gshB GO:0000287,GO:0003674,GO:0003824,GO:0004363,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006518,GO:0006575,GO:0006749,GO:0006750,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0019184,GO:0034641,GO:0042398,GO:0043043,GO:0043167,GO:0043169,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0051186,GO:0051188,GO:0071704,GO:1901564,GO:1901566,GO:1901576 6.3.2.3 ko:K01920 ko00270,ko00480,ko01100,map00270,map00480,map01100 M00118 R00497,R10994 RC00096,RC00141 ko00000,ko00001,ko00002,ko01000 - - iECED1_1282.ECED1_3410,iECP_1309.ECP_2941 GSH-S_ATP,GSH-S_N k59_1228295_1 98439.AJLL01000061_gene661 1.31e-34 132.0 COG0568@1|root,COG0568@2|Bacteria,1G0DU@1117|Cyanobacteria,1JHZU@1189|Stigonemataceae 1117|Cyanobacteria K Sigma-70 factor, region 1.2 sigA - - ko:K03086 - - - - ko00000,ko03021 - - - Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4 k59_491138_1 1123037.AUDE01000028_gene2989 1.4e-105 320.0 COG3172@1|root,COG3172@2|Bacteria,4NEQF@976|Bacteroidetes,1HYEB@117743|Flavobacteriia 976|Bacteroidetes H Domain of unknown function (DUF4301) - - - - - - - - - - - - AAA_28,DUF4301 k59_943531_1 196367.JNFG01000023_gene8186 1.81e-68 219.0 COG2301@1|root,COG2301@2|Bacteria,1RCCS@1224|Proteobacteria,2VQUU@28216|Betaproteobacteria,1KIC2@119060|Burkholderiaceae 28216|Betaproteobacteria H HpcH/HpaI aldolase/citrate lyase family - - 4.1.3.34 ko:K01644 ko02020,map02020 - R00362 RC00067,RC01118 ko00000,ko00001,ko01000 - - - HpcH_HpaI k59_100018_1 1121004.ATVC01000002_gene563 1.86e-10 67.4 COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2VHTK@28216|Betaproteobacteria,2KSQE@206351|Neisseriales 206351|Neisseriales T PAS fold - - - - - - - - - - - - HATPase_c,HisKA,PAS_4,PAS_7,Response_reg k59_609213_1 443906.CMM_2183 1.87e-47 171.0 COG1173@1|root,COG1173@2|Bacteria,2GJ9E@201174|Actinobacteria,4FK7A@85023|Microbacteriaceae 201174|Actinobacteria EP Binding-protein-dependent transport system inner membrane component oppC - - ko:K02034 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1,OppC_N k59_943542_1 1122137.AQXF01000002_gene299 3.6e-174 497.0 COG0519@1|root,COG0519@2|Bacteria,1MU2A@1224|Proteobacteria,2TRN0@28211|Alphaproteobacteria 28211|Alphaproteobacteria F Catalyzes the synthesis of GMP from XMP guaA GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046037,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 6.3.5.2 ko:K01951 ko00230,ko00983,ko01100,map00230,map00983,map01100 M00050 R01230,R01231,R08244 RC00010,RC00204 ko00000,ko00001,ko00002,ko01000,ko01002 - - - GATase,GMP_synt_C,NAD_synthase k59_773395_1 251229.Chro_0825 4.06e-171 497.0 COG1115@1|root,COG1115@2|Bacteria,1G1I5@1117|Cyanobacteria,3VJ8N@52604|Pleurocapsales 1117|Cyanobacteria E PFAM Sodium alanine symporter family - - - ko:K03310 - - - - ko00000 2.A.25 - - Na_Ala_symp k59_1736545_1 305900.GV64_23175 2.79e-33 118.0 COG2193@1|root,COG2193@2|Bacteria,1RF3C@1224|Proteobacteria,1S72I@1236|Gammaproteobacteria 1236|Gammaproteobacteria P Ferritin-like domain - - 1.16.3.1 ko:K03594 ko00860,map00860 - R00078 RC02758 ko00000,ko00001,ko01000 - - - Ferritin k59_1736545_2 1123270.ATUR01000006_gene155 1.33e-41 150.0 COG2807@1|root,COG2807@2|Bacteria,1QUSV@1224|Proteobacteria,2TW64@28211|Alphaproteobacteria,2K0D2@204457|Sphingomonadales 204457|Sphingomonadales P Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 k59_661780_1 483219.LILAB_16180 1.9e-96 298.0 COG3146@1|root,COG3146@2|Bacteria,1MU35@1224|Proteobacteria,42RUS@68525|delta/epsilon subdivisions,2WNWT@28221|Deltaproteobacteria,2YWXA@29|Myxococcales 28221|Deltaproteobacteria S Peptidogalycan biosysnthesis/recognition - - - ko:K09919 - - - - ko00000 - - - FemAB_like k59_1623851_1 996637.SGM_4006 7.12e-12 68.2 COG0318@1|root,COG0318@2|Bacteria,2GIUC@201174|Actinobacteria 201174|Actinobacteria IQ PFAM AMP-dependent synthetase and ligase - - 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding,AMP-binding_C k59_435387_1 1088721.NSU_1243 5.79e-85 259.0 29W19@1|root,30HJP@2|Bacteria,1R60N@1224|Proteobacteria,2TV4D@28211|Alphaproteobacteria,2K2WI@204457|Sphingomonadales 204457|Sphingomonadales - - - - - - - - - - - - - - - k59_269506_1 1122137.AQXF01000006_gene791 6.54e-181 527.0 COG0525@1|root,COG0525@2|Bacteria,1MV7B@1224|Proteobacteria,2TS9E@28211|Alphaproteobacteria 28211|Alphaproteobacteria J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner valS GO:0003674,GO:0003824,GO:0004812,GO:0004832,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006438,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.9 ko:K01873 ko00970,map00970 M00359,M00360 R03665 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1 k59_722667_1 1336235.JAEG01000012_gene4056 9.43e-80 248.0 COG0409@1|root,COG0409@2|Bacteria,1MU1F@1224|Proteobacteria,2TSE4@28211|Alphaproteobacteria,4BB53@82115|Rhizobiaceae 28211|Alphaproteobacteria O Hydrogenase formation hypA family hypD - - ko:K04654 - - - - ko00000 - - - HypD k59_722667_2 580332.Slit_2422 1.7e-28 104.0 COG0298@1|root,COG0298@2|Bacteria,1N76Y@1224|Proteobacteria,2VVZH@28216|Betaproteobacteria,44WJT@713636|Nitrosomonadales 28216|Betaproteobacteria O PFAM hydrogenase expression formation protein (HUPF HYPC) hypC - - ko:K04653 - - - - ko00000 - - - HupF_HypC k59_722667_3 1123368.AUIS01000008_gene2250 1.65e-15 76.3 COG0068@1|root,COG0068@2|Bacteria,1MVP8@1224|Proteobacteria,1RP08@1236|Gammaproteobacteria,2NC37@225057|Acidithiobacillales 225057|Acidithiobacillales O Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide - - - ko:K04656 - - - - ko00000 - - - Acylphosphatase,Sua5_yciO_yrdC,zf-HYPF k59_435390_1 290397.Adeh_1944 4.94e-08 51.2 COG0089@1|root,COG0089@2|Bacteria,1MZXX@1224|Proteobacteria,42V3Y@68525|delta/epsilon subdivisions,2WRMX@28221|Deltaproteobacteria,2Z0X0@29|Myxococcales 28221|Deltaproteobacteria J One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome rplW GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02892 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L23 k59_1068575_1 1415778.JQMM01000001_gene1133 5.57e-38 134.0 29B18@1|root,2ZY02@2|Bacteria,1REMG@1224|Proteobacteria,1S4B1@1236|Gammaproteobacteria,1JA2W@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_1007281_1 1144319.PMI16_02356 2.43e-120 356.0 COG1290@1|root,COG1290@2|Bacteria,1MV97@1224|Proteobacteria,2VHP5@28216|Betaproteobacteria,4727H@75682|Oxalobacteraceae 28216|Betaproteobacteria C Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis petB - - ko:K00412 ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016 M00151,M00152 - - ko00000,ko00001,ko00002,ko03029 - - - Cytochrom_B_C,Cytochrome_B k59_1796732_1 1122137.AQXF01000001_gene3279 1.85e-154 457.0 COG0495@1|root,COG0495@2|Bacteria,1MV47@1224|Proteobacteria,2TQPK@28211|Alphaproteobacteria 28211|Alphaproteobacteria J Belongs to the class-I aminoacyl-tRNA synthetase family leuS GO:0003674,GO:0003824,GO:0004812,GO:0004823,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006429,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.4 ko:K01869 ko00970,map00970 M00359,M00360 R03657 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - Anticodon_1,tRNA-synt_1,tRNA-synt_1_2 k59_1290821_1 398767.Glov_0027 2.71e-49 177.0 COG0188@1|root,COG0188@2|Bacteria,1MUGG@1224|Proteobacteria,42KZ9@68525|delta/epsilon subdivisions,2WJBC@28221|Deltaproteobacteria,43T5S@69541|Desulfuromonadales 28221|Deltaproteobacteria L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrA - 5.99.1.3 ko:K02469 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseA_C,DNA_topoisoIV k59_554610_1 710685.MycrhN_5484 1.47e-29 122.0 COG2936@1|root,COG2936@2|Bacteria,2GK8B@201174|Actinobacteria,235H0@1762|Mycobacteriaceae 201174|Actinobacteria S peptidase S15 - - - ko:K06978 - - - - ko00000 - - - PepX_C,Peptidase_S15 k59_781157_1 1122137.AQXF01000001_gene2898 6.23e-40 148.0 COG2199@1|root,COG2199@2|Bacteria,1PPIP@1224|Proteobacteria,2U091@28211|Alphaproteobacteria 28211|Alphaproteobacteria T COG2202 FOG PAS PAC domain - - - - - - - - - - - - GGDEF,PAS,PAS_4,PAS_9 k59_669822_1 1283300.ATXB01000001_gene1193 1.38e-37 134.0 COG3752@1|root,COG3752@2|Bacteria,1MXCP@1224|Proteobacteria,1RQID@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Membrane - - - - - - - - - - - - DUF1295 k59_669822_2 196367.JNFG01000038_gene7649 5.77e-10 58.9 2CH72@1|root,32ZK4@2|Bacteria,1N8YD@1224|Proteobacteria,2VVUJ@28216|Betaproteobacteria,1K9FP@119060|Burkholderiaceae 28216|Betaproteobacteria S Protein of unknown function (DUF2878) - - - - - - - - - - - - DUF2878 k59_1007285_1 1485544.JQKP01000005_gene346 4.6e-104 322.0 COG0542@1|root,COG0542@2|Bacteria,1MV8B@1224|Proteobacteria,2VH1K@28216|Betaproteobacteria,44VIS@713636|Nitrosomonadales 28216|Betaproteobacteria O TIGRFAM ATP-dependent Clp protease, ATP-binding subunit clpA clpA - - ko:K03694 - - - - ko00000,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N k59_1007286_1 338969.Rfer_2156 2.24e-52 187.0 COG1640@1|root,COG3280@1|root,COG1640@2|Bacteria,COG3280@2|Bacteria,1QTVJ@1224|Proteobacteria,2WGPV@28216|Betaproteobacteria,4AD3R@80864|Comamonadaceae 28216|Betaproteobacteria G SMART alpha amylase catalytic sub domain treY - 2.4.1.25,5.4.99.15 ko:K00705,ko:K06044 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R01824,R05196,R09995 RC00049 ko00000,ko00001,ko00002,ko01000 - GH13,GH77 - Alpha-amylase,Glyco_hydro_77 k59_1687486_2 455436.DS989810_gene180 3.73e-19 79.7 COG0291@1|root,COG0291@2|Bacteria,1N6V4@1224|Proteobacteria,1SCHI@1236|Gammaproteobacteria,468CG@72275|Alteromonadaceae 1236|Gammaproteobacteria J Belongs to the bacterial ribosomal protein bL35 family rpmI GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - ko:K02916 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L35p k59_1687486_3 556268.OFAG_00066 1.09e-25 100.0 COG0290@1|root,COG0290@2|Bacteria,1RDD2@1224|Proteobacteria,2VQ19@28216|Betaproteobacteria,473AV@75682|Oxalobacteraceae 28216|Betaproteobacteria J IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins infC - - ko:K02520 - - - - ko00000,ko03012,ko03029 - - - IF3_C,IF3_N k59_1290846_1 1144310.PMI07_002709 5.79e-104 311.0 COG1089@1|root,COG1089@2|Bacteria,1MUX0@1224|Proteobacteria,2TR8G@28211|Alphaproteobacteria,4B6ZB@82115|Rhizobiaceae 28211|Alphaproteobacteria M Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose gmd - 4.2.1.47 ko:K01711 ko00051,ko00520,ko01100,map00051,map00520,map01100 - R00888 RC00402 ko00000,ko00001,ko01000 - - - GDP_Man_Dehyd k59_900918_1 1122603.ATVI01000005_gene3762 8e-29 126.0 COG4773@1|root,COG4773@2|Bacteria,1QTXJ@1224|Proteobacteria,1T2K9@1236|Gammaproteobacteria,1XD9B@135614|Xanthomonadales 135614|Xanthomonadales P TonB dependent receptor - - - - - - - - - - - - Plug,TonB_dep_Rec k59_277942_2 1121372.AULK01000007_gene417 3.17e-06 49.7 COG4221@1|root,COG4221@2|Bacteria,2I2YS@201174|Actinobacteria,4FKTS@85023|Microbacteriaceae 201174|Actinobacteria S KR domain - - - - - - - - - - - - adh_short k59_1460530_1 158500.BV97_03274 0.0 896.0 COG0146@1|root,COG0146@2|Bacteria,1QU46@1224|Proteobacteria,2TVYU@28211|Alphaproteobacteria,2K11U@204457|Sphingomonadales 204457|Sphingomonadales EQ PFAM Hydantoinase B oxoprolinase - - 3.5.2.14 ko:K01474 ko00330,ko01100,map00330,map01100 - R03187 RC00632 ko00000,ko00001,ko01000 - - - Hydantoinase_B k59_1290850_1 1123228.AUIH01000009_gene1913 2.91e-19 87.0 COG0495@1|root,COG0495@2|Bacteria,1MV47@1224|Proteobacteria,1RP14@1236|Gammaproteobacteria,1XHWN@135619|Oceanospirillales 135619|Oceanospirillales J due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm leuS - 6.1.1.4 ko:K01869 ko00970,map00970 M00359,M00360 R03657 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - Anticodon_1,tRNA-synt_1,tRNA-synt_1_2 k59_1290850_2 1265313.HRUBRA_00734 5.31e-54 176.0 COG2980@1|root,COG2980@2|Bacteria,1PSFI@1224|Proteobacteria,1SE86@1236|Gammaproteobacteria,1J796@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane lptE - - ko:K03643 - - - - ko00000,ko02000 1.B.42.1 - - LptE k59_1290850_3 247634.GPB2148_1072 3.25e-12 65.5 COG1466@1|root,COG1466@2|Bacteria,1MWYT@1224|Proteobacteria,1RQRE@1236|Gammaproteobacteria,1J58M@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L DNA polymerase III delta subunit holA GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0032991,GO:0034641,GO:0034645,GO:0042575,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0090304,GO:1901360,GO:1901576,GO:1902494,GO:1990234 2.7.7.7 ko:K02340 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_delt_C,DNA_pol3_delta k59_1579469_1 1192034.CAP_0004 2.27e-131 389.0 COG1249@1|root,COG1249@2|Bacteria,1MU2Z@1224|Proteobacteria,42MMZ@68525|delta/epsilon subdivisions,2WJF0@28221|Deltaproteobacteria,2YWP5@29|Myxococcales 28221|Deltaproteobacteria C Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family gor - 1.8.1.7 ko:K00383 ko00480,ko04918,map00480,map04918 - R00094,R00115 RC00011 ko00000,ko00001,ko01000 - - - Pyr_redox_2,Pyr_redox_dim k59_617751_1 247634.GPB2148_1295 8.76e-91 273.0 COG0052@1|root,COG0052@2|Bacteria,1MU33@1224|Proteobacteria,1RN0Z@1236|Gammaproteobacteria,1J5AE@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Belongs to the universal ribosomal protein uS2 family rpsB GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046872,GO:0046914,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02967 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S2 k59_162788_1 1178825.ALIH01000003_gene2005 3.79e-114 354.0 COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,4NDVA@976|Bacteroidetes,1HXMT@117743|Flavobacteriia 976|Bacteroidetes L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity polA - 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1 k59_781201_1 941449.dsx2_2051 7.59e-26 107.0 COG0637@1|root,COG1554@1|root,COG0637@2|Bacteria,COG1554@2|Bacteria,1MWJE@1224|Proteobacteria,42Q4Z@68525|delta/epsilon subdivisions,2WM28@28221|Deltaproteobacteria,2M9SQ@213115|Desulfovibrionales 28221|Deltaproteobacteria G PFAM Glycoside hydrolase family 65, central catalytic - - - - - - - - - - - - Glyco_hydro_65C,Glyco_hydro_65N,Glyco_hydro_65m,HAD_2,Hydrolase k59_781201_2 196162.Noca_3421 2.05e-25 106.0 COG1554@1|root,COG1554@2|Bacteria,2GKEV@201174|Actinobacteria,4DNX8@85009|Propionibacteriales 201174|Actinobacteria G Glycosyl hydrolase family 65 central catalytic domain - - 2.4.1.64 ko:K05342 ko00500,ko01100,map00500,map01100 - R02727 RC00049 ko00000,ko00001,ko01000 - GH65 - Glyco_hydro_65C,Glyco_hydro_65N,Glyco_hydro_65m k59_1409641_1 1177179.A11A3_08545 2.2e-76 248.0 COG3320@1|root,COG4221@1|root,COG3320@2|Bacteria,COG4221@2|Bacteria,1QSHC@1224|Proteobacteria,1RQP8@1236|Gammaproteobacteria,1XMDW@135619|Oceanospirillales 135619|Oceanospirillales M dehydrogenase domain of multifunctional non-ribosomal peptide synthetases and related enzymes - - - - - - - - - - - - NAD_binding_4,adh_short k59_219910_1 702113.PP1Y_AT16904 1.79e-62 200.0 COG0652@1|root,COG0652@2|Bacteria,1RGF5@1224|Proteobacteria,2U980@28211|Alphaproteobacteria,2K19C@204457|Sphingomonadales 204457|Sphingomonadales M peptidyl-prolyl cis-trans isomerase - - 5.2.1.8 ko:K03767 ko01503,ko04217,map01503,map04217 - - - ko00000,ko00001,ko01000,ko03110,ko04147 - - - Phytase-like,Pro_isomerase k59_900930_1 493475.GARC_1181 3.7e-12 68.9 COG1629@1|root,COG4206@1|root,COG1629@2|Bacteria,COG4206@2|Bacteria,1QUTW@1224|Proteobacteria,1T3T4@1236|Gammaproteobacteria,465DE@72275|Alteromonadaceae 1236|Gammaproteobacteria HP receptor - - - - - - - - - - - - Plug,TonB_dep_Rec k59_900930_2 322710.Avin_04360 5.77e-44 157.0 COG1453@1|root,COG1453@2|Bacteria,1NIR6@1224|Proteobacteria,1T3EJ@1236|Gammaproteobacteria 1236|Gammaproteobacteria S 4Fe-4S dicluster domain - - - - - - - - - - - - Fer4_22 k59_1236079_1 316407.85674942 1.36e-113 330.0 COG1024@1|root,COG1024@2|Bacteria,1MWZC@1224|Proteobacteria,1RPSX@1236|Gammaproteobacteria 1236|Gammaproteobacteria I Belongs to the enoyl-CoA hydratase isomerase family paaF GO:0003674,GO:0003824,GO:0004300,GO:0005488,GO:0005515,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0006725,GO:0006805,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009404,GO:0009407,GO:0009410,GO:0009636,GO:0009850,GO:0009852,GO:0009987,GO:0010124,GO:0010817,GO:0016042,GO:0016054,GO:0016829,GO:0016835,GO:0016836,GO:0019395,GO:0019439,GO:0019748,GO:0019752,GO:0030258,GO:0032787,GO:0034440,GO:0042178,GO:0042221,GO:0042445,GO:0042447,GO:0042537,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0046395,GO:0050896,GO:0051716,GO:0055114,GO:0065007,GO:0065008,GO:0070887,GO:0071466,GO:0071704,GO:0072329,GO:0098754,GO:1901360,GO:1901361,GO:1901575 4.2.1.17 ko:K01692 ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212 M00032,M00087 R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093 RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 - - - ECH_1 k59_1236080_2 1163408.UU9_03957 2.35e-19 87.0 COG0664@1|root,COG0664@2|Bacteria,1MVGE@1224|Proteobacteria,1RPTB@1236|Gammaproteobacteria,1X4Z7@135614|Xanthomonadales 135614|Xanthomonadales K COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases - - - ko:K01420 - - - - ko00000,ko03000 - - - HTH_Crp_2,cNMP_binding k59_1579481_2 571166.KI421509_gene366 7.64e-14 75.9 COG4148@1|root,COG4148@2|Bacteria,1MU8K@1224|Proteobacteria,2TR1Z@28211|Alphaproteobacteria 28211|Alphaproteobacteria P Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system modC GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 3.6.3.29 ko:K02017 ko02010,map02010 M00189 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.8 - - ABC_tran,TOBE k59_1121490_1 41431.PCC8801_3684 5.69e-63 219.0 COG1020@1|root,COG3882@1|root,COG1020@2|Bacteria,COG3882@2|Bacteria,1GM4C@1117|Cyanobacteria,3KJ7V@43988|Cyanothece 1117|Cyanobacteria Q Pfam:HxxPF_rpt - - - - - - - - - - - - Condensation k59_1521881_1 1245471.PCA10_12010 5.64e-82 265.0 COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,1RNBK@1236|Gammaproteobacteria,1YDAK@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria IQ AMP-binding enzyme C-terminal domain - - - ko:K00666 - - - - ko00000,ko01000,ko01004 - - - AMP-binding,AMP-binding_C k59_730964_1 436308.Nmar_1056 1.17e-12 65.5 COG1573@1|root,arCOG00905@2157|Archaea,41SJ1@651137|Thaumarchaeota 651137|Thaumarchaeota L uracil-DNA glycosylase - - 3.2.2.27 ko:K21929 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - UDG k59_730964_2 935839.JAGJ01000007_gene3260 7.34e-23 98.6 COG2094@1|root,COG2094@2|Bacteria,2GNW1@201174|Actinobacteria,4F474@85017|Promicromonosporaceae 201174|Actinobacteria L Methylpurine-DNA glycosylase (MPG) alkA GO:0003674,GO:0003824,GO:0003905,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360 3.2.2.21 ko:K03652 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - Pur_DNA_glyco k59_730964_3 1131266.ARWQ01000006_gene274 1.41e-40 136.0 arCOG08729@1|root,arCOG08729@2157|Archaea,41T79@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_730964_4 436308.Nmar_1058 2.97e-80 243.0 arCOG03119@1|root,arCOG03119@2157|Archaea,41SMJ@651137|Thaumarchaeota 651137|Thaumarchaeota S SNARE associated Golgi protein - - - - - - - - - - - - SNARE_assoc k59_277974_1 351607.Acel_1287 1.7e-106 322.0 COG0161@1|root,COG0161@2|Bacteria,2GKF6@201174|Actinobacteria,4ERWH@85013|Frankiales 201174|Actinobacteria H Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family tpa - - - - - - - - - - - Aminotran_3 k59_1521883_1 1167006.UWK_03128 1.24e-34 132.0 COG1253@1|root,COG1253@2|Bacteria,1MWT3@1224|Proteobacteria,42N45@68525|delta/epsilon subdivisions,2WKUD@28221|Deltaproteobacteria,2MHZA@213118|Desulfobacterales 28221|Deltaproteobacteria S CBS domain - - - - - - - - - - - - CBS,DUF21 k59_1121506_1 713586.KB900536_gene1371 5.32e-60 195.0 COG0812@1|root,COG0812@2|Bacteria,1MXDH@1224|Proteobacteria,1RNXK@1236|Gammaproteobacteria,1WW8T@135613|Chromatiales 135613|Chromatiales M Cell wall formation murB - 1.3.1.98 ko:K00075 ko00520,ko00550,ko01100,map00520,map00550,map01100 - R03191,R03192 RC02639 ko00000,ko00001,ko01000,ko01011 - - - FAD_binding_4,MurB_C k59_1121506_2 977880.RALTA_A2727 2.05e-35 130.0 COG1181@1|root,COG1181@2|Bacteria,1MUTB@1224|Proteobacteria,2VHIW@28216|Betaproteobacteria,1K3MM@119060|Burkholderiaceae 28216|Betaproteobacteria F Cell wall formation ddl - 6.3.2.4 ko:K01921 ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502 - R01150 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Dala_Dala_lig_C,Dala_Dala_lig_N k59_52373_1 1121296.JONJ01000014_gene321 3.4e-29 121.0 COG0358@1|root,COG0358@2|Bacteria,1TQ0X@1239|Firmicutes,2480W@186801|Clostridia,21YKE@1506553|Lachnoclostridium 186801|Clostridia L RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication dnaG - - ko:K02316 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB,DnaB_bind,Toprim_2,Toprim_4,Toprim_N,zf-CHC2 k59_900971_1 1121935.AQXX01000127_gene1162 2.32e-64 221.0 COG0747@1|root,COG3210@1|root,COG0747@2|Bacteria,COG3210@2|Bacteria,1QUXB@1224|Proteobacteria,1T32K@1236|Gammaproteobacteria,1XMGN@135619|Oceanospirillales 135619|Oceanospirillales U domain, Protein - - - - - - - - - - - - - k59_840763_1 1121921.KB898712_gene2149 5.57e-51 180.0 COG3250@1|root,COG3250@2|Bacteria,1MXXM@1224|Proteobacteria,1RYMD@1236|Gammaproteobacteria,2PN2T@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria G Pfam:DUF303 - - 3.1.1.53 ko:K05970 - - - - ko00000,ko01000 - - - BetaGal_dom4_5,Glyco_hydro_2_N,SASA k59_617807_1 572478.Vdis_0232 2.48e-09 66.6 COG2030@1|root,arCOG00775@1|root,arCOG00774@2157|Archaea,arCOG00775@2157|Archaea,2XRUR@28889|Crenarchaeota 28889|Crenarchaeota I PFAM MaoC like domain - - 4.2.1.148 ko:K14449 ko00630,ko00660,ko00720,ko01120,ko01200,map00630,map00660,map00720,map01120,map01200 M00373,M00376,M00740 R05076 RC01984 ko00000,ko00001,ko00002,ko01000 - - - MaoC_dehydratas k59_1347041_1 1229909.NSED_00585 6.22e-13 67.0 COG1492@1|root,arCOG00105@2157|Archaea,41SG6@651137|Thaumarchaeota 651137|Thaumarchaeota H Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation cobQ - 6.3.5.10 ko:K02232 ko00860,ko01100,map00860,map01100 M00122 R05225 RC00010,RC01302 ko00000,ko00001,ko00002,ko01000 - - - CbiA k59_1347041_2 1131266.ARWQ01000009_gene955 2.49e-83 258.0 COG0079@1|root,arCOG04273@2157|Archaea,41SGU@651137|Thaumarchaeota 651137|Thaumarchaeota E PFAM Aminotransferase class I and II - - 4.1.1.81 ko:K04720 ko00860,map00860 - R06530 RC00517 ko00000,ko00001,ko01000 - - - Aminotran_1_2 k59_108348_1 1121940.AUDZ01000005_gene1682 3.77e-42 144.0 COG2859@1|root,COG2859@2|Bacteria,1QU0K@1224|Proteobacteria,1RR22@1236|Gammaproteobacteria,1XNBP@135619|Oceanospirillales 135619|Oceanospirillales S Protein of unknown function (DUF541) - - - ko:K09797 - - - - ko00000 - - - SIMPL k59_108348_2 314285.KT71_01635 1.92e-114 335.0 COG3484@1|root,COG3484@2|Bacteria,1N057@1224|Proteobacteria,1RRR0@1236|Gammaproteobacteria,1J84B@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O Proteasome subunit - - - ko:K07395 - - - - ko00000 - - - Proteasome k59_108348_3 857087.Metme_2726 7.05e-26 106.0 COG0366@1|root,COG0366@2|Bacteria,1MVKX@1224|Proteobacteria,1RMXP@1236|Gammaproteobacteria,1XEE5@135618|Methylococcales 1236|Gammaproteobacteria G SMART Glycosyl hydrolase, family 13, subfamily, catalytic region ycjM - 2.4.1.7 ko:K00690 ko00500,map00500 - R00803 RC00028 ko00000,ko00001,ko01000 - GH13 - Alpha-amylase,DUF3459,Malt_amylase_C k59_1579509_2 1131266.ARWQ01000005_gene813 7.38e-08 52.0 arCOG08758@1|root,arCOG08758@2157|Archaea,41SVS@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_392786_2 1313421.JHBV01000041_gene3512 0.000202 44.3 COG2819@1|root,COG2819@2|Bacteria,4NN8M@976|Bacteroidetes,1IQIY@117747|Sphingobacteriia 976|Bacteroidetes S Putative esterase - - - ko:K07017 - - - - ko00000 - - - Esterase,TPR_8 k59_951805_1 1459636.NTE_02476 8.53e-84 256.0 COG2086@1|root,arCOG00446@2157|Archaea,41SX2@651137|Thaumarchaeota 651137|Thaumarchaeota C Electron transfer flavoprotein domain - - - ko:K03521 - - - - ko00000 - - - ETF k59_1796811_1 436308.Nmar_1497 8.05e-74 231.0 arCOG03932@1|root,arCOG03932@2157|Archaea,41SKB@651137|Thaumarchaeota 651137|Thaumarchaeota K Cobalamin B12-binding domain protein - - - - - - - - - - - - - k59_1796811_2 1229909.NSED_08235 2.22e-13 66.6 COG0526@1|root,arCOG00314@2157|Archaea,41SKE@651137|Thaumarchaeota 651137|Thaumarchaeota O Redoxin - - - - - - - - - - - - AhpC-TSA k59_1007347_2 765952.PUV_00830 2e-09 61.6 COG0861@1|root,COG0861@2|Bacteria,2JGY6@204428|Chlamydiae 204428|Chlamydiae P Integral membrane protein TerC family - - - ko:K05794 - - - - ko00000 - - - TerC k59_1290919_1 870967.VIS19158_02350 1.73e-21 98.2 COG1574@1|root,COG1574@2|Bacteria,1MWP2@1224|Proteobacteria,1RNB7@1236|Gammaproteobacteria,1XTUF@135623|Vibrionales 135623|Vibrionales S metal-dependent hydrolase with the TIM-barrel fold - - - - - - - - - - - - Amidohydro_3 k59_1796813_1 1121912.AUHD01000011_gene737 1.49e-88 271.0 COG0179@1|root,COG0179@2|Bacteria,4NGI0@976|Bacteroidetes,1HXN9@117743|Flavobacteriia 976|Bacteroidetes Q Fumarylacetoacetase fahA - 3.7.1.2 ko:K01555 ko00350,ko00643,ko01100,ko01120,map00350,map00643,map01100,map01120 M00044 R01364 RC00326,RC00446 ko00000,ko00001,ko00002,ko01000,ko04147 - - - FAA_hydrolase,FAA_hydrolase_N k59_162861_2 436308.Nmar_1662 2.23e-41 147.0 COG0428@1|root,arCOG00576@2157|Archaea,41S6R@651137|Thaumarchaeota 651137|Thaumarchaeota P divalent heavy-metal cations transporter - - - - - - - - - - - - - k59_1796817_1 316407.21239026 1.38e-166 466.0 COG0528@1|root,COG0528@2|Bacteria,1MV3N@1224|Proteobacteria,1RMHX@1236|Gammaproteobacteria,3XP3X@561|Escherichia 1236|Gammaproteobacteria F Catalyzes the reversible phosphorylation of UMP to UDP pyrH GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009165,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0033862,GO:0034641,GO:0034654,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.4.22 ko:K09903 ko00240,ko01100,map00240,map01100 - R00158 RC00002 ko00000,ko00001,ko01000 - - - AA_kinase k59_554741_1 330214.NIDE2928 3.27e-87 264.0 2CHNQ@1|root,2Z7KM@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_443697_1 398720.MED217_14945 1.39e-53 181.0 COG4409@1|root,COG4409@2|Bacteria 2|Bacteria G exo-alpha-(2->6)-sialidase activity nanH - 3.2.1.18 ko:K01186 ko00511,ko00600,ko04142,map00511,map00600,map04142 - R04018 RC00028,RC00077 ko00000,ko00001,ko01000,ko02042 - GH33 - BNR_2,CW_binding_1,F5_F8_type_C,NPCBM_assoc k59_840790_1 365528.KB891246_gene6447 2.16e-12 67.8 COG1028@1|root,COG1028@2|Bacteria,2I9FM@201174|Actinobacteria,4EU1P@85013|Frankiales 201174|Actinobacteria IQ Enoyl-(Acyl carrier protein) reductase - - - - - - - - - - - - adh_short_C2 k59_840790_2 1041522.MCOL_V203300 2.45e-39 147.0 COG0318@1|root,COG0318@2|Bacteria,2GMVB@201174|Actinobacteria,236WM@1762|Mycobacteriaceae 201174|Actinobacteria IQ COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II - - - - - - - - - - - - AMP-binding,AMP-binding_C k59_781274_1 556268.OFAG_02107 6.25e-32 126.0 COG0075@1|root,COG0075@2|Bacteria,1MWHJ@1224|Proteobacteria,2VNWB@28216|Betaproteobacteria,478EE@75682|Oxalobacteraceae 28216|Betaproteobacteria E Aminotransferase class-V - - 2.6.1.44,2.6.1.45,2.6.1.51 ko:K00830 ko00250,ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko04146,map00250,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200,map04146 M00346,M00532 R00369,R00372,R00585,R00588 RC00006,RC00008,RC00018 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_5 k59_1632298_1 1298593.TOL_0496 1.03e-40 140.0 COG5005@1|root,COG5005@2|Bacteria,1QEN6@1224|Proteobacteria,1TBER@1236|Gammaproteobacteria,1XQFM@135619|Oceanospirillales 135619|Oceanospirillales S Phage virion morphogenesis family - - - - - - - - - - - - Phage_tail_S k59_617841_1 1123247.AUIJ01000008_gene2533 1.36e-88 270.0 COG1638@1|root,COG1638@2|Bacteria,1MVHC@1224|Proteobacteria,2TS46@28211|Alphaproteobacteria 28211|Alphaproteobacteria G COG1638 TRAP-type C4-dicarboxylate transport system, periplasmic component dctP - - ko:K11688 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.56.1 - - DctP k59_278054_1 158500.BV97_01923 9.04e-98 306.0 COG2274@1|root,COG2274@2|Bacteria,1R2T0@1224|Proteobacteria,2USBQ@28211|Alphaproteobacteria,2K0KD@204457|Sphingomonadales 204457|Sphingomonadales V ABC-type bacteriocin lantibiotic exporters, contain an N-terminal double-glycine peptidase domain hlyB - - ko:K11004 ko02010,ko03070,ko05133,map02010,map03070,map05133 M00325,M00575 - - ko00000,ko00001,ko00002,ko02000,ko02044 3.A.1.109.1,3.A.1.109.2 - - ABC_membrane,ABC_tran,Peptidase_C39 k59_1687556_1 1411685.U062_01787 3.05e-51 167.0 COG2259@1|root,COG2259@2|Bacteria,1RBZP@1224|Proteobacteria,1S28E@1236|Gammaproteobacteria,1J5W4@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S DoxX - - - - - - - - - - - - DoxX k59_1122660_2 1191523.MROS_1503 2.89e-14 69.3 COG1917@1|root,COG1917@2|Bacteria 2|Bacteria L Cupin 2, conserved barrel domain protein - - - - - - - - - - - - Cupin_2,DUF4437 k59_555804_1 1524880.A0A076G6J2_9VIRU 5.35e-68 224.0 4QD9Y@10239|Viruses 10239|Viruses S Pfam:Terminase_6C - - - - - - - - - - - - - k59_1237137_2 158500.BV97_02751 1.37e-110 327.0 COG1028@1|root,COG1028@2|Bacteria,1MU3W@1224|Proteobacteria,2TT5X@28211|Alphaproteobacteria,2K05I@204457|Sphingomonadales 204457|Sphingomonadales IQ Short-chain dehydrogenase reductase sdr - - - - - - - - - - - - adh_short_C2 k59_782373_1 521460.Athe_1331 1.06e-34 136.0 COG0013@1|root,COG0013@2|Bacteria,1TPK6@1239|Firmicutes,248M3@186801|Clostridia,42EUK@68295|Thermoanaerobacterales 186801|Clostridia J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain alaS - 6.1.1.7 ko:K01872 ko00970,map00970 M00359,M00360 R03038 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DHHA1,tRNA-synt_2c,tRNA_SAD k59_618999_1 438753.AZC_0170 7.59e-69 222.0 COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,2TQW5@28211|Alphaproteobacteria,3F17M@335928|Xanthobacteraceae 28211|Alphaproteobacteria G Tripartite ATP-independent periplasmic transporter, DctM component - - - - - - - - - - - - DctM k59_221025_1 1172185.KB911517_gene1674 1.03e-27 114.0 COG1960@1|root,COG1960@2|Bacteria,2H211@201174|Actinobacteria 201174|Actinobacteria I Acyl-CoA dehydrogenase, C-terminal domain - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_N k59_221025_2 337191.KTR9_2786 1.05e-67 235.0 COG1960@1|root,COG1960@2|Bacteria,2GM1Q@201174|Actinobacteria,4GDMK@85026|Gordoniaceae 201174|Actinobacteria I Acyl-CoA dehydrogenase, middle domain - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_340112_1 953739.SVEN_5432 5.6e-63 201.0 COG1126@1|root,COG1126@2|Bacteria,2GIZW@201174|Actinobacteria 201174|Actinobacteria E ABC transporter, ATP-binding protein - - - ko:K10008 ko02010,map02010 M00233 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.3.9 - - ABC_tran k59_452868_1 72004.XP_005893422.1 2.65e-10 63.2 COG2032@1|root,KOG0441@2759|Eukaryota,3A1IR@33154|Opisthokonta,3BQA3@33208|Metazoa,3D760@33213|Bilateria,48E5V@7711|Chordata,49AW9@7742|Vertebrata,3JGNV@40674|Mammalia,4J5C9@91561|Cetartiodactyla 33208|Metazoa P Superoxide dismutase SOD1 GO:0000003,GO:0000187,GO:0000209,GO:0000302,GO:0000303,GO:0000305,GO:0000323,GO:0000902,GO:0000904,GO:0001306,GO:0001541,GO:0001817,GO:0001819,GO:0001890,GO:0001894,GO:0001895,GO:0001932,GO:0001934,GO:0001975,GO:0002064,GO:0002065,GO:0002066,GO:0002093,GO:0002262,GO:0002376,GO:0002520,GO:0002576,GO:0002682,GO:0002694,GO:0003006,GO:0003008,GO:0003012,GO:0003013,GO:0003015,GO:0003018,GO:0003674,GO:0003824,GO:0004784,GO:0004842,GO:0005488,GO:0005507,GO:0005515,GO:0005575,GO:0005576,GO:0005615,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005740,GO:0005758,GO:0005759,GO:0005764,GO:0005773,GO:0005777,GO:0005829,GO:0006464,GO:0006508,GO:0006511,GO:0006518,GO:0006575,GO:0006749,GO:0006790,GO:0006801,GO:0006807,GO:0006810,GO:0006873,GO:0006875,GO:0006879,GO:0006887,GO:0006928,GO:0006937,GO:0006940,GO:0006950,GO:0006979,GO:0006996,GO:0007009,GO:0007010,GO:0007017,GO:0007018,GO:0007154,GO:0007165,GO:0007166,GO:0007272,GO:0007275,GO:0007276,GO:0007283,GO:0007399,GO:0007422,GO:0007423,GO:0007548,GO:0007565,GO:0007566,GO:0007568,GO:0007569,GO:0007571,GO:0007584,GO:0007600,GO:0007605,GO:0007610,GO:0007626,GO:0008015,GO:0008088,GO:0008089,GO:0008090,GO:0008150,GO:0008152,GO:0008217,GO:0008270,GO:0008366,GO:0008406,GO:0008544,GO:0008585,GO:0009056,GO:0009057,GO:0009058,GO:0009266,GO:0009408,GO:0009410,GO:0009605,GO:0009611,GO:0009628,GO:0009636,GO:0009653,GO:0009719,GO:0009790,GO:0009887,GO:0009888,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009913,GO:0009966,GO:0009967,GO:0009987,GO:0009991,GO:0010001,GO:0010033,GO:0010035,GO:0010038,GO:0010243,GO:0010256,GO:0010498,GO:0010556,GO:0010557,GO:0010562,GO:0010604,GO:0010646,GO:0010647,GO:0010894,GO:0010941,GO:0010942,GO:0010970,GO:0012505,GO:0014037,GO:0014044,GO:0014070,GO:0014074,GO:0014075,GO:0016043,GO:0016192,GO:0016209,GO:0016491,GO:0016567,GO:0016721,GO:0016740,GO:0016999,GO:0017000,GO:0017016,GO:0017048,GO:0017144,GO:0019216,GO:0019218,GO:0019220,GO:0019221,GO:0019222,GO:0019226,GO:0019430,GO:0019538,GO:0019725,GO:0019787,GO:0019899,GO:0019902,GO:0019903,GO:0019941,GO:0019953,GO:0021782,GO:0022008,GO:0022011,GO:0022414,GO:0023051,GO:0023052,GO:0023056,GO:0030003,GO:0030030,GO:0030141,GO:0030154,GO:0030163,GO:0030182,GO:0030346,GO:0030425,GO:0030705,GO:0030855,GO:0031012,GO:0031045,GO:0031175,GO:0031267,GO:0031323,GO:0031325,GO:0031399,GO:0031401,GO:0031410,GO:0031667,GO:0031668,GO:0031669,GO:0031670,GO:0031967,GO:0031970,GO:0031974,GO:0031975,GO:0031981,GO:0031982,GO:0032147,GO:0032268,GO:0032270,GO:0032287,GO:0032292,GO:0032446,GO:0032501,GO:0032502,GO:0032504,GO:0032838,GO:0032839,GO:0032928,GO:0032930,GO:0032940,GO:0032989,GO:0032991,GO:0033081,GO:0033198,GO:0033554,GO:0033674,GO:0034097,GO:0034465,GO:0034599,GO:0034614,GO:0034641,GO:0035150,GO:0035296,GO:0035315,GO:0035637,GO:0035690,GO:0035722,GO:0035864,GO:0035865,GO:0036211,GO:0036477,GO:0040008,GO:0040014,GO:0040028,GO:0042063,GO:0042221,GO:0042311,GO:0042325,GO:0042327,GO:0042391,GO:0042471,GO:0042472,GO:0042490,GO:0042491,GO:0042493,GO:0042542,GO:0042552,GO:0042554,GO:0042579,GO:0042592,GO:0042743,GO:0042802,GO:0042803,GO:0042981,GO:0042995,GO:0043005,GO:0043025,GO:0043065,GO:0043066,GO:0043067,GO:0043068,GO:0043069,GO:0043085,GO:0043087,GO:0043161,GO:0043167,GO:0043169,GO:0043170,GO:0043209,GO:0043217,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043405,GO:0043406,GO:0043408,GO:0043410,GO:0043412,GO:0043523,GO:0043524,GO:0043549,GO:0043583,GO:0043603,GO:0043632,GO:0044057,GO:0044093,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044297,GO:0044419,GO:0044421,GO:0044422,GO:0044424,GO:0044428,GO:0044429,GO:0044444,GO:0044446,GO:0044463,GO:0044464,GO:0044557,GO:0044703,GO:0044706,GO:0045055,GO:0045103,GO:0045104,GO:0045137,GO:0045471,GO:0045540,GO:0045541,GO:0045580,GO:0045595,GO:0045619,GO:0045833,GO:0045859,GO:0045860,GO:0045932,GO:0045937,GO:0045939,GO:0045986,GO:0046545,GO:0046620,GO:0046660,GO:0046677,GO:0046683,GO:0046686,GO:0046688,GO:0046716,GO:0046872,GO:0046890,GO:0046903,GO:0046907,GO:0046914,GO:0046916,GO:0046983,GO:0048232,GO:0048365,GO:0048468,GO:0048513,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048534,GO:0048538,GO:0048562,GO:0048568,GO:0048580,GO:0048583,GO:0048584,GO:0048598,GO:0048608,GO:0048609,GO:0048638,GO:0048666,GO:0048667,GO:0048678,GO:0048699,GO:0048731,GO:0048732,GO:0048839,GO:0048856,GO:0048869,GO:0048871,GO:0048872,GO:0048878,GO:0050665,GO:0050789,GO:0050790,GO:0050793,GO:0050794,GO:0050801,GO:0050810,GO:0050863,GO:0050865,GO:0050877,GO:0050880,GO:0050896,GO:0050954,GO:0051020,GO:0051055,GO:0051087,GO:0051171,GO:0051173,GO:0051174,GO:0051179,GO:0051186,GO:0051188,GO:0051234,GO:0051239,GO:0051240,GO:0051241,GO:0051246,GO:0051247,GO:0051249,GO:0051336,GO:0051338,GO:0051347,GO:0051597,GO:0051603,GO:0051641,GO:0051649,GO:0051704,GO:0051716,GO:0051769,GO:0051770,GO:0051881,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0055114,GO:0060047,GO:0060052,GO:0060087,GO:0060088,GO:0060113,GO:0060117,GO:0060119,GO:0060122,GO:0060249,GO:0060255,GO:0060378,GO:0060429,GO:0060548,GO:0060563,GO:0061024,GO:0061062,GO:0061458,GO:0062012,GO:0062014,GO:0065007,GO:0065008,GO:0065009,GO:0070013,GO:0070050,GO:0070647,GO:0070671,GO:0070887,GO:0071241,GO:0071248,GO:0071276,GO:0071310,GO:0071318,GO:0071345,GO:0071349,GO:0071407,GO:0071417,GO:0071450,GO:0071451,GO:0071495,GO:0071496,GO:0071704,GO:0071840,GO:0071900,GO:0071902,GO:0072593,GO:0080090,GO:0080134,GO:0080135,GO:0090066,GO:0090075,GO:0090181,GO:0090206,GO:0090257,GO:0090322,GO:0090596,GO:0097237,GO:0097305,GO:0097332,GO:0097366,GO:0097447,GO:0097458,GO:0097708,GO:0097746,GO:0097755,GO:0098754,GO:0098771,GO:0098869,GO:0098930,GO:0099111,GO:0099503,GO:0099568,GO:0106118,GO:0106119,GO:0120025,GO:0120036,GO:0120038,GO:0120111,GO:0140096,GO:1900407,GO:1900409,GO:1901214,GO:1901215,GO:1901564,GO:1901565,GO:1901575,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902105,GO:1902175,GO:1902177,GO:1902531,GO:1902533,GO:1902882,GO:1902884,GO:1902930,GO:1902931,GO:1903201,GO:1903209,GO:1903409,GO:1903706,GO:1990748,GO:2000026,GO:2000377,GO:2000379,GO:2001233,GO:2001235,GO:2001242,GO:2001244 1.15.1.1 ko:K04565 ko04146,ko04213,ko05014,ko05016,ko05020,map04146,map04213,map05014,map05016,map05020 - - - ko00000,ko00001,ko01000 - - - Sod_Cu k59_1582906_1 1394178.AWOO02000023_gene5566 6.25e-77 243.0 COG0160@1|root,COG0160@2|Bacteria,2GKUY@201174|Actinobacteria,4EI46@85012|Streptosporangiales 201174|Actinobacteria E Aminotransferase class-III ectB - 2.6.1.76 ko:K00836 ko00260,ko01100,ko01120,ko01210,ko01230,map00260,map01100,map01120,map01210,map01230 M00033 R06977 RC00006,RC00062 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 k59_1300608_1 1120983.KB894571_gene2250 4.53e-124 363.0 COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2TQWK@28211|Alphaproteobacteria,1JPZ9@119043|Rhodobiaceae 28211|Alphaproteobacteria S Tripartite tricarboxylate transporter family receptor - - - - - - - - - - - - TctC k59_283708_1 1144307.PMI04_01375 2.24e-90 274.0 COG0583@1|root,COG0583@2|Bacteria,1MXDQ@1224|Proteobacteria,2TVHJ@28211|Alphaproteobacteria,2K21M@204457|Sphingomonadales 204457|Sphingomonadales K LysR family - - - - - - - - - - - - HTH_1,LysR_substrate k59_283708_2 114615.BRADO0018 1.57e-44 152.0 COG1028@1|root,COG1028@2|Bacteria,1MXNY@1224|Proteobacteria,2U126@28211|Alphaproteobacteria,3JUEP@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria IQ Enoyl-(Acyl carrier protein) reductase - - - - - - - - - - - - adh_short_C2 k59_1018184_1 1415778.JQMM01000001_gene636 3.36e-64 202.0 COG0762@1|root,COG0762@2|Bacteria,1RCZV@1224|Proteobacteria,1S6DW@1236|Gammaproteobacteria,1J6HX@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S integral membrane protein yggT GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K02221 - - - - ko00000,ko02044 - - - YGGT k59_678962_1 1121106.JQKB01000028_gene4185 1.8e-07 58.5 COG0810@1|root,COG0810@2|Bacteria,1MZPX@1224|Proteobacteria,2UHNB@28211|Alphaproteobacteria,2JUGI@204441|Rhodospirillales 204441|Rhodospirillales M Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins - - - ko:K03832 - - - - ko00000,ko02000 2.C.1.1 - - TonB_C k59_1752355_1 1121441.AUCX01000004_gene3111 2.78e-43 158.0 COG0405@1|root,COG0405@2|Bacteria,1MUV6@1224|Proteobacteria,42Q48@68525|delta/epsilon subdivisions,2X5G4@28221|Deltaproteobacteria,2MGQF@213115|Desulfovibrionales 28221|Deltaproteobacteria E Gamma-glutamyltranspeptidase - - 2.3.2.2,3.4.19.13 ko:K00681 ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100 - R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935 RC00064,RC00090,RC00096 ko00000,ko00001,ko01000,ko01002 - - - G_glu_transpept k59_1639436_1 1122137.AQXF01000005_gene1207 3.78e-78 254.0 COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2TQR1@28211|Alphaproteobacteria 28211|Alphaproteobacteria C belongs to the aldehyde dehydrogenase family aldA - 1.2.1.3 ko:K00128 ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130 M00135 R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146 RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_1639436_2 1122137.AQXF01000005_gene1208 3.12e-107 316.0 COG0274@1|root,COG0274@2|Bacteria,1N8AG@1224|Proteobacteria,2TS26@28211|Alphaproteobacteria 28211|Alphaproteobacteria F Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate deoC - 4.1.2.4 ko:K01619 ko00030,map00030 - R01066 RC00436,RC00437 ko00000,ko00001,ko01000 - - - DeoC k59_622439_1 765420.OSCT_0205 4.93e-58 191.0 COG1173@1|root,COG1173@2|Bacteria,2G6HB@200795|Chloroflexi,375I1@32061|Chloroflexia 32061|Chloroflexia P PFAM binding-protein-dependent transport systems inner membrane component - - - ko:K02034 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1,OppC_N k59_509479_1 1122137.AQXF01000007_gene3584 2.99e-59 188.0 2CGK2@1|root,2ZSMN@2|Bacteria,1PB67@1224|Proteobacteria,2UWR1@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_509479_2 412597.AEPN01000009_gene1774 2.95e-36 131.0 COG0800@1|root,COG0800@2|Bacteria,1MUVJ@1224|Proteobacteria,2TUMH@28211|Alphaproteobacteria,2PWKF@265|Paracoccus 28211|Alphaproteobacteria G Catalyzes the formation of pyruvate and glyoxylate from 4-hydroxy-2-oxoglutarate eda GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 4.1.2.14,4.1.3.42 ko:K01625 ko00030,ko00630,ko01100,ko01120,ko01200,map00030,map00630,map01100,map01120,map01200 M00008,M00061,M00308,M00631 R00470,R05605 RC00307,RC00308,RC00435 ko00000,ko00001,ko00002,ko01000 - - - Aldolase k59_1582923_1 1265313.HRUBRA_01167 3.61e-62 200.0 COG0136@1|root,COG0136@2|Bacteria,1MUHG@1224|Proteobacteria,1RNB6@1236|Gammaproteobacteria,1J5B6@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate asd GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004073,GO:0006082,GO:0006520,GO:0006549,GO:0006553,GO:0006555,GO:0006566,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009081,GO:0009082,GO:0009085,GO:0009086,GO:0009088,GO:0009089,GO:0009097,GO:0009987,GO:0016053,GO:0016491,GO:0016620,GO:0016903,GO:0019752,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046451,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.2.1.11 ko:K00133 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00017,M00018,M00033,M00525,M00526,M00527 R02291 RC00684 ko00000,ko00001,ko00002,ko01000 - - - Semialdhyde_dh,Semialdhyde_dhC k59_1582923_2 1122604.JONR01000025_gene4570 5.22e-06 47.4 COG0082@1|root,COG0082@2|Bacteria,1MU98@1224|Proteobacteria,1RMQS@1236|Gammaproteobacteria,1X365@135614|Xanthomonadales 135614|Xanthomonadales E Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system aroC GO:0000166,GO:0003674,GO:0003824,GO:0004107,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0010181,GO:0016053,GO:0016829,GO:0016835,GO:0016838,GO:0019438,GO:0019752,GO:0032553,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050662,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 4.2.3.5 ko:K01736 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R01714 RC00586 ko00000,ko00001,ko00002,ko01000 - - - Chorismate_synt k59_735665_1 509190.Cseg_1079 5.27e-70 225.0 COG0402@1|root,COG0402@2|Bacteria,1MUPT@1224|Proteobacteria,2TU1V@28211|Alphaproteobacteria,2KIZZ@204458|Caulobacterales 204458|Caulobacterales F TIGRFAM guanine deaminase - - 3.5.4.3 ko:K01487 ko00230,ko01100,map00230,map01100 - R01676 RC00204 ko00000,ko00001,ko01000 - - - Amidohydro_1 k59_340147_1 76114.ebA2533 2.44e-56 194.0 COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,2VHGH@28216|Betaproteobacteria,2KUY0@206389|Rhodocyclales 206389|Rhodocyclales S COG0488 ATPase components of ABC transporters with duplicated ATPase domains yheS - - ko:K06158 - - - - ko00000,ko03012 - - - ABC_tran,ABC_tran_CTD,ABC_tran_Xtn k59_1695836_1 1209072.ALBT01000012_gene3456 9.12e-05 48.9 COG0810@1|root,COG0810@2|Bacteria,1RJI3@1224|Proteobacteria,1SA6H@1236|Gammaproteobacteria 1236|Gammaproteobacteria U Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins - - - ko:K03832 - - - - ko00000,ko02000 2.C.1.1 - - TonB_C k59_57690_2 1297742.A176_05131 5.36e-08 57.4 COG0206@1|root,COG0206@2|Bacteria,1MV2X@1224|Proteobacteria,42MHK@68525|delta/epsilon subdivisions,2WJAZ@28221|Deltaproteobacteria,2YTTW@29|Myxococcales 28221|Deltaproteobacteria D Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity ftsZ - - ko:K03531 ko04112,map04112 - - - ko00000,ko00001,ko02048,ko03036,ko04812 - - - FtsZ_C,Tubulin k59_396550_1 258594.RPA2194 1.1e-60 213.0 COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,2TQMW@28211|Alphaproteobacteria,3JQVN@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria C Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain MA20_27485 - 1.2.5.3 ko:K03520 - - R11168 RC02800 ko00000,ko01000 - - - Ald_Xan_dh_C,Ald_Xan_dh_C2 k59_735672_1 498211.CJA_1080 6.03e-93 289.0 COG0155@1|root,COG0155@2|Bacteria,1MVVB@1224|Proteobacteria,1RMFH@1236|Gammaproteobacteria,1FG54@10|Cellvibrio 1236|Gammaproteobacteria C Nitrite and sulphite reductase 4Fe-4S domain cysI - 1.8.1.2 ko:K00381 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00176 R00858 RC00065 ko00000,ko00001,ko00002,ko01000 - - - NIR_SIR,NIR_SIR_ferr k59_1074321_1 1096930.L284_16790 1.38e-148 424.0 COG0196@1|root,COG0196@2|Bacteria,1MV9I@1224|Proteobacteria,2TTUY@28211|Alphaproteobacteria,2K0M2@204457|Sphingomonadales 204457|Sphingomonadales H Belongs to the ribF family ribF - 2.7.1.26,2.7.7.2 ko:K11753 ko00740,ko01100,ko01110,map00740,map01100,map01110 M00125 R00161,R00549 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - FAD_syn,Flavokinase k59_566138_1 1232410.KI421415_gene2984 1.18e-59 194.0 COG1999@1|root,COG1999@2|Bacteria,1R9EM@1224|Proteobacteria,42N5F@68525|delta/epsilon subdivisions,2WKG7@28221|Deltaproteobacteria,43RX9@69541|Desulfuromonadales 28221|Deltaproteobacteria S protein SCO1 SenC PrrC involved in biogenesis of respiratory and photosynthetic systems sco - - ko:K07152 - - - - ko00000,ko03029 - - - - k59_566138_2 243231.GSU0219 1.37e-05 47.0 COG0843@1|root,COG0843@2|Bacteria,1MU7S@1224|Proteobacteria,42M18@68525|delta/epsilon subdivisions,2WJUK@28221|Deltaproteobacteria,43S0R@69541|Desulfuromonadales 28221|Deltaproteobacteria C Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B coxA - 1.10.3.10,1.9.3.1 ko:K02274,ko:K02298 ko00190,ko01100,map00190,map01100 M00155,M00417 R00081,R11335 RC00016,RC00061 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.5,3.D.4.6 - - COX1 k59_1695851_1 1123487.KB892834_gene3080 5.25e-75 227.0 COG0346@1|root,COG0346@2|Bacteria,1N3A9@1224|Proteobacteria,2W2MH@28216|Betaproteobacteria,2KYUS@206389|Rhodocyclales 206389|Rhodocyclales E Glyoxalase-like domain - - - - - - - - - - - - Glyoxalase k59_396559_1 316407.85677046 4.35e-20 81.6 COG3414@1|root,COG3414@2|Bacteria,1RKWM@1224|Proteobacteria,1S6WB@1236|Gammaproteobacteria 1236|Gammaproteobacteria G The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane sgcB GO:0006810,GO:0008150,GO:0008643,GO:0009401,GO:0051179,GO:0051234,GO:0071702 2.7.1.200 ko:K02774 ko00052,ko01100,ko02060,map00052,map01100,map02060 M00279 R05570 RC00017,RC03206 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.5.1 - - PTS_IIB k59_396559_2 316407.85677047 1.97e-105 312.0 COG1363@1|root,COG1363@2|Bacteria,1MXEU@1224|Proteobacteria,1RYRZ@1236|Gammaproteobacteria,3XN5P@561|Escherichia 1236|Gammaproteobacteria G Has a broad aminopeptidase activity on non-blocked peptides by progressively cleaving amino acids off the peptide substrate. Aminopeptidase activity stops at the residue before the first proline in the peptide. Cannot cleave when proline is the first N-terminal residue sgcX GO:0003674,GO:0003824,GO:0004177,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0008238,GO:0016787,GO:0019538,GO:0043170,GO:0044238,GO:0070011,GO:0071704,GO:0140096,GO:1901564 - ko:K18530,ko:K20609 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M42 k59_1187412_1 1123504.JQKD01000038_gene3019 6.74e-45 163.0 28IUR@1|root,2Z8TE@2|Bacteria,1NW7C@1224|Proteobacteria,2W0UN@28216|Betaproteobacteria,4AGJ7@80864|Comamonadaceae 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_170651_1 1122197.ATWI01000011_gene413 2.77e-62 214.0 COG0348@1|root,COG3901@1|root,COG0348@2|Bacteria,COG3901@2|Bacteria,1MY5M@1224|Proteobacteria,1RNSU@1236|Gammaproteobacteria,465B0@72275|Alteromonadaceae 1236|Gammaproteobacteria CK Regulator of nitric oxide reductase transcription yccM GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K19339 - - - - ko00000,ko03000 - - - FMN_bind,Fer4,Fer4_5 k59_509503_1 1492922.GY26_18990 9.29e-28 112.0 COG0322@1|root,COG0322@2|Bacteria,1MV38@1224|Proteobacteria,1RNGV@1236|Gammaproteobacteria,1J4GN@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision uvrC GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009314,GO:0009380,GO:0009381,GO:0009628,GO:0009987,GO:0016787,GO:0016788,GO:0032991,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1902494,GO:1905347,GO:1905348,GO:1990391 - ko:K03703 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - GIY-YIG,HHH,HHH_2,HHH_5,UVR,UvrC_HhH_N k59_509503_2 1122212.AULO01000011_gene567 3.44e-31 115.0 COG0558@1|root,COG0558@2|Bacteria,1RCZ7@1224|Proteobacteria,1S465@1236|Gammaproteobacteria,1XJF2@135619|Oceanospirillales 135619|Oceanospirillales I Belongs to the CDP-alcohol phosphatidyltransferase class-I family pgsA - 2.7.8.41,2.7.8.5 ko:K00995,ko:K08744 ko00564,ko01100,map00564,map01100 - R01801,R02030 RC00002,RC00017,RC02795 ko00000,ko00001,ko01000 - - - CDP-OH_P_transf k59_1074331_1 290398.Csal_2755 2.78e-23 104.0 COG4258@1|root,COG4258@2|Bacteria,1MU1E@1224|Proteobacteria,1RMP8@1236|Gammaproteobacteria,1XH8E@135619|Oceanospirillales 135619|Oceanospirillales S exporter - - - - - - - - - - - - MMPL k59_1639461_1 1121921.KB898706_gene2535 4.12e-26 108.0 COG2942@1|root,COG2942@2|Bacteria,1P7CS@1224|Proteobacteria,1S0PA@1236|Gammaproteobacteria,2PN8M@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria G N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase) unk2 - 5.1.3.11 ko:K16213 - - R01445,R10810 RC00289 ko00000,ko01000 - - - GlcNAc_2-epim k59_1300681_1 1137281.D778_01102 3.38e-114 345.0 COG3975@1|root,COG3975@2|Bacteria,4NE4D@976|Bacteroidetes,1HXD0@117743|Flavobacteriia 976|Bacteroidetes S Peptidase, M61 - - - - - - - - - - - - PDZ_2,Peptidase_M61 k59_961432_1 436308.Nmar_1783 4.8e-58 187.0 COG2112@1|root,arCOG01182@2157|Archaea,41SJV@651137|Thaumarchaeota 651137|Thaumarchaeota T Ser thr protein kinase - - - ko:K07176 - - - - ko00000 - - - RIO1 k59_283774_1 159749.E7BWJ3 1.11e-12 66.6 28JJ8@1|root,2QRYE@2759|Eukaryota 2759|Eukaryota C chlorophyll binding psaA GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0009507,GO:0009534,GO:0009535,GO:0009536,GO:0009579,GO:0016020,GO:0031976,GO:0031984,GO:0034357,GO:0042651,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044436,GO:0044444,GO:0044446,GO:0044464,GO:0055035 - ko:K02689,ko:K02690 ko00195,ko01100,map00195,map01100 M00163 - - ko00000,ko00001,ko00002,ko00194 - - - PsaA_PsaB k59_1131097_1 1049564.TevJSym_ca00050 1.46e-71 240.0 COG1033@1|root,COG2834@1|root,COG1033@2|Bacteria,COG2834@2|Bacteria,1MUE1@1224|Proteobacteria,1RPIP@1236|Gammaproteobacteria,1J96Q@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M MMPL family VP1286 - - ko:K07003 - - - - ko00000 - - - MMPL k59_227083_1 247633.GP2143_01950 7.46e-05 44.3 2EZXX@1|root,33T24@2|Bacteria,1NQQH@1224|Proteobacteria 1224|Proteobacteria S Tellurite resistance protein TerB - - - - - - - - - - - - TerB k59_1018233_1 870187.Thini_2509 2.17e-64 212.0 COG0168@1|root,COG0168@2|Bacteria,1MUIJ@1224|Proteobacteria,1RMN6@1236|Gammaproteobacteria,45ZP9@72273|Thiotrichales 72273|Thiotrichales P Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA trkH - - ko:K03498 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - - TrkH k59_1526467_1 498211.CJA_0031 6.67e-08 53.9 COG0577@1|root,COG0577@2|Bacteria,1R88B@1224|Proteobacteria,1S1I0@1236|Gammaproteobacteria,1FG3S@10|Cellvibrio 1236|Gammaproteobacteria V MacB-like periplasmic core domain - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_1526467_2 498211.CJA_0032 1.07e-67 218.0 COG0845@1|root,COG0845@2|Bacteria,1MU8D@1224|Proteobacteria,1RN0E@1236|Gammaproteobacteria,1FFXB@10|Cellvibrio 1236|Gammaproteobacteria M Biotin-lipoyl like macA - - ko:K02005 - - - - ko00000 - - - Biotin_lipoyl_2,HlyD_3,HlyD_D23 k59_1244001_1 436308.Nmar_1521 1.1e-92 275.0 arCOG10589@1|root,arCOG10589@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_1244001_2 436308.Nmar_1522 1.69e-58 192.0 arCOG08643@1|root,arCOG08643@2157|Archaea,41T5M@651137|Thaumarchaeota 651137|Thaumarchaeota S peptidyl-tyrosine sulfation - - - - - - - - - - - - - k59_566170_1 436308.Nmar_0031 7.64e-07 53.5 arCOG10512@1|root,arCOG10512@2157|Archaea,41T3J@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1018235_1 1122137.AQXF01000002_gene181 3.81e-137 410.0 COG5000@1|root,COG5000@2|Bacteria,1MWKZ@1224|Proteobacteria,2TQTB@28211|Alphaproteobacteria 28211|Alphaproteobacteria T Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation ntrY GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 2.7.13.3 ko:K13598 ko02020,map02020 M00498 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,HisKA,PAS,PAS_4 k59_284794_1 1122137.AQXF01000007_gene3605 9.67e-130 397.0 COG2352@1|root,COG2352@2|Bacteria 2|Bacteria C phosphoenolpyruvate carboxylase activity - - 4.1.1.31 ko:K01595 ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200 M00168,M00170,M00171,M00172,M00173,M00346,M00374 R00345 RC02741 ko00000,ko00001,ko00002,ko01000 - - - PEPcase k59_284794_2 551275.KB899545_gene3007 1.14e-06 51.2 COG0364@1|root,COG0364@2|Bacteria,1MUN0@1224|Proteobacteria,2TQXA@28211|Alphaproteobacteria,43WJP@69657|Hyphomonadaceae 28211|Alphaproteobacteria G Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone zwf - 1.1.1.363,1.1.1.49 ko:K00036 ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230 M00004,M00006,M00008 R00835,R02736,R10907 RC00001,RC00066 ko00000,ko00001,ko00002,ko01000,ko04147 - - - G6PD_C,G6PD_N k59_284795_1 1038867.AXAY01000030_gene7082 1.84e-140 404.0 COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,1MW7X@1224|Proteobacteria,2TTH8@28211|Alphaproteobacteria,3JWD8@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria L DDE superfamily endonuclease - - - ko:K07494 - - - - ko00000 - - - DDE_3,HTH_23,HTH_29,HTH_32 k59_736746_1 675813.VIB_001825 1.66e-59 201.0 COG3540@1|root,COG3540@2|Bacteria,1MWAF@1224|Proteobacteria,1RNY4@1236|Gammaproteobacteria,1XVJ1@135623|Vibrionales 135623|Vibrionales P PhoD-like phosphatase, N-terminal domain - - 3.1.3.1 ko:K01113 ko00790,ko01100,ko02020,map00790,map01100,map02020 M00126 R04620 RC00017 ko00000,ko00001,ko00002,ko01000 - - - PhoD,PhoD_N k59_1696849_1 1056820.KB900685_gene2821 8.19e-88 272.0 COG0500@1|root,COG2226@2|Bacteria,1PFIM@1224|Proteobacteria,1SXHR@1236|Gammaproteobacteria,2PPGW@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria Q O-methyltransferase - - - - - - - - - - - - Methyltransf_11,PP-binding k59_510466_1 155864.EDL933_5261 1.83e-193 538.0 COG1575@1|root,COG1575@2|Bacteria,1MXQQ@1224|Proteobacteria,1RPW5@1236|Gammaproteobacteria,3XNGM@561|Escherichia 1236|Gammaproteobacteria H Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK) menA GO:0000287,GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0006766,GO:0006775,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009233,GO:0009234,GO:0009987,GO:0016020,GO:0016740,GO:0016765,GO:0032194,GO:0042180,GO:0042181,GO:0042362,GO:0042371,GO:0042373,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046428,GO:0046872,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:1901576,GO:1901661,GO:1901663 2.5.1.74 ko:K02548 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116 R05617,R06858,R10757 RC02935,RC02936,RC03264 ko00000,ko00001,ko00002,ko01000,ko01006 - - iECH74115_1262.ECH74115_5387,iG2583_1286.G2583_4737 UbiA k59_1188489_2 1144342.PMI40_03164 4.51e-41 149.0 COG0114@1|root,COG0114@2|Bacteria,1MUQI@1224|Proteobacteria,2VHA5@28216|Betaproteobacteria,472U1@75682|Oxalobacteraceae 28216|Betaproteobacteria C Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate fumC - 4.2.1.2 ko:K01679 ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04934,ko05200,ko05211,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200,map04934,map05200,map05211 M00009,M00011,M00173,M00376 R01082 RC00443 ko00000,ko00001,ko00002,ko01000 - - - FumaraseC_C,Lyase_1 k59_567252_1 1122137.AQXF01000004_gene1737 1.17e-06 46.6 COG1278@1|root,COG1278@2|Bacteria,1N6Q5@1224|Proteobacteria 1224|Proteobacteria K Cold shock cspA - - ko:K03704 - - - - ko00000,ko03000 - - - CSD k59_567252_2 1380391.JIAS01000015_gene352 3.03e-06 52.8 COG5388@1|root,COG5388@2|Bacteria,1Q1Q6@1224|Proteobacteria,2UKHQ@28211|Alphaproteobacteria 2|Bacteria S PAS domain - - - - - - - - - - - - PAS_5 k59_736750_1 450851.PHZ_p0312 1.18e-11 70.1 COG0664@1|root,COG0664@2|Bacteria,1MXID@1224|Proteobacteria,2TT42@28211|Alphaproteobacteria 28211|Alphaproteobacteria K COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases - - - ko:K10914 ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111 - - - ko00000,ko00001,ko03000 - - - HTH_Crp_2,cNMP_binding k59_1075248_1 935557.ATYB01000009_gene734 1.11e-19 93.2 COG2203@1|root,COG4191@1|root,COG2203@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TR8X@28211|Alphaproteobacteria,4BBZJ@82115|Rhizobiaceae 28211|Alphaproteobacteria T Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - - - - - - - - - - GAF_2,HATPase_c,HisKA,PAS,PAS_4,PAS_7,PAS_9 k59_1696856_1 313606.M23134_05947 2.62e-06 49.3 COG3579@1|root,COG3579@2|Bacteria,4NE02@976|Bacteroidetes 976|Bacteroidetes E Peptidase C1-like family pepC - 3.4.22.40 ko:K01372 - - - - ko00000,ko01000,ko01002 - - - Peptidase_C1,Peptidase_C1_2 k59_1696856_3 391598.FBBAL38_12610 1.98e-20 88.6 COG2996@1|root,COG2996@2|Bacteria,4NGS6@976|Bacteroidetes,1HYJ6@117743|Flavobacteriia 976|Bacteroidetes S protein conserved in bacteria yitL - - ko:K00243 - - - - ko00000 - - - S1_2 k59_1358053_1 1234664.AMRO01000076_gene2450 1.13e-60 199.0 COG0502@1|root,COG0502@2|Bacteria,1TPQ4@1239|Firmicutes,4HAGM@91061|Bacilli,1WEI6@129337|Geobacillus 91061|Bacilli H Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism bioB - 2.8.1.6 ko:K01012 ko00780,ko01100,map00780,map01100 M00123,M00573,M00577 R01078 RC00441 ko00000,ko00001,ko00002,ko01000 - - iYO844.BSU30200 BATS,Radical_SAM k59_1131981_1 1040989.AWZU01000092_gene1243 9.41e-102 310.0 COG2133@1|root,COG2133@2|Bacteria,1RI7V@1224|Proteobacteria,2UNGB@28211|Alphaproteobacteria,3K55D@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria G pyrroloquinoline quinone binding - - - - - - - - - - - - - k59_397632_1 1117319.PSPO_03495 7.74e-16 77.0 COG4147@1|root,COG4147@2|Bacteria,1MVJ8@1224|Proteobacteria,1RN0R@1236|Gammaproteobacteria,2PZGX@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria S Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family actP - - ko:K14393 - - - - ko00000,ko02000 2.A.21.7 - - SSF k59_397632_2 566466.NOR53_1757 3.34e-212 598.0 COG0624@1|root,COG0624@2|Bacteria,1MUSU@1224|Proteobacteria,1RNIW@1236|Gammaproteobacteria,1J5FR@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E COG0624 Acetylornithine deacetylase Succinyl-diaminopimelate desuccinylase and related deacylases cpg2_2 - 3.4.17.11 ko:K01295 - - - - ko00000,ko01000,ko01002 - - - M20_dimer,Peptidase_M20,Peptidase_M28 k59_397632_3 1089552.KI911559_gene1481 3.54e-13 69.3 COG1230@1|root,COG1230@2|Bacteria,1MVQB@1224|Proteobacteria,2TR65@28211|Alphaproteobacteria,2JRGG@204441|Rhodospirillales 204441|Rhodospirillales P Cation efflux family - - - ko:K16264 - - - - ko00000,ko02000 2.A.4.1 - - Cation_efflux k59_623531_1 1385517.N800_13895 8.44e-05 50.8 COG0745@1|root,COG0784@1|root,COG0840@1|root,COG1511@1|root,COG2203@1|root,COG2770@1|root,COG5002@1|root,COG0745@2|Bacteria,COG0784@2|Bacteria,COG0840@2|Bacteria,COG1511@2|Bacteria,COG2203@2|Bacteria,COG2770@2|Bacteria,COG5002@2|Bacteria,1NC9X@1224|Proteobacteria,1SVEC@1236|Gammaproteobacteria,1XDBG@135614|Xanthomonadales 135614|Xanthomonadales T Histidine kinase - - - - - - - - - - - - CHASE3,GAF_2,HATPase_c,HisKA,Response_reg k59_453981_1 1286631.X805_07940 1.36e-60 199.0 COG5008@1|root,COG5008@2|Bacteria,1QTTX@1224|Proteobacteria,2VIWS@28216|Betaproteobacteria,1KJHY@119065|unclassified Burkholderiales 28216|Betaproteobacteria NU twitching motility protein pilU - - ko:K02670 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE k59_623536_2 243365.CV_3507 2.77e-50 166.0 COG0603@1|root,COG0603@2|Bacteria,1MU5V@1224|Proteobacteria,2VHY3@28216|Betaproteobacteria,2KQ1A@206351|Neisseriales 206351|Neisseriales F Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) queC - 6.3.4.20 ko:K06920 ko00790,ko01100,map00790,map01100 - R09978 RC00959 ko00000,ko00001,ko01000,ko03016 - - - QueC k59_1414473_1 305900.GV64_01255 8.78e-69 213.0 COG0288@1|root,COG0288@2|Bacteria,1NGFN@1224|Proteobacteria,1RSY6@1236|Gammaproteobacteria,1XJD9@135619|Oceanospirillales 135619|Oceanospirillales P Reversible hydration of carbon dioxide yadF - 4.2.1.1 ko:K01673 ko00910,map00910 - R00132,R10092 RC02807 ko00000,ko00001,ko01000 - - - Pro_CA k59_1358083_1 1229909.NSED_01445 1.58e-148 430.0 COG0036@1|root,COG3959@1|root,arCOG01053@2157|Archaea,arCOG05046@2157|Archaea,41SBE@651137|Thaumarchaeota 651137|Thaumarchaeota G Transketolase, thiamine diphosphate binding domain - - 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 - - - Ribul_P_3_epim,Transketolase_N k59_1188532_1 1502851.FG93_04260 6.28e-77 235.0 COG3293@1|root,COG3293@2|Bacteria,1PVIT@1224|Proteobacteria,2TURP@28211|Alphaproteobacteria,3JWWQ@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria L Putative transposase of IS4/5 family (DUF4096) - - - - - - - - - - - - DDE_Tnp_1,DDE_Tnp_1_2,DUF4096 k59_1132002_1 1049564.TevJSym_ak00330 2.9e-56 189.0 COG1055@1|root,COG1055@2|Bacteria,1MUX4@1224|Proteobacteria,1RMAV@1236|Gammaproteobacteria,1JBHG@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria U Involved in arsenical resistance. Thought to form the channel of an arsenite pump - - - - - - - - - - - - ArsB,CitMHS k59_741180_1 1229909.NSED_08715 1.54e-30 112.0 COG3945@1|root,arCOG01471@2157|Archaea,41T3D@651137|Thaumarchaeota 651137|Thaumarchaeota S Hemerythrin HHE cation binding - - - - - - - - - - - - Hemerythrin k59_741180_2 1229909.NSED_08720 5.36e-24 93.2 arCOG10596@1|root,arCOG10596@2157|Archaea,41T8F@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1249459_2 436308.Nmar_0435 3.29e-34 120.0 COG2892@1|root,arCOG04414@2157|Archaea,41T5I@651137|Thaumarchaeota 651137|Thaumarchaeota S protein conserved in archaea - - - ko:K09741 - - - - ko00000,ko03016 - - - Pcc1 k59_1588154_1 1454004.AW11_00335 2.33e-37 137.0 COG0160@1|root,COG0160@2|Bacteria,1QY1E@1224|Proteobacteria,2WI1Y@28216|Betaproteobacteria 28216|Betaproteobacteria E Aminotransferase class-III - - 2.6.1.19 ko:K00823 ko00250,ko00410,ko00640,ko00650,ko01100,ko01120,map00250,map00410,map00640,map00650,map01100,map01120 M00027 R00908,R01648 RC00006,RC00062 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 k59_63686_1 83406.HDN1F_33560 1.06e-92 289.0 COG2812@1|root,COG2812@2|Bacteria,1MVCK@1224|Proteobacteria,1RMIA@1236|Gammaproteobacteria,1J4KC@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity dnaX GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030234,GO:0030337,GO:0032991,GO:0034641,GO:0034645,GO:0042575,GO:0042802,GO:0043170,GO:0043846,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050790,GO:0061695,GO:0065007,GO:0065009,GO:0071704,GO:0090304,GO:0098772,GO:1901360,GO:1901576,GO:1902494,GO:1990234 2.7.7.7 ko:K02343 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_delta2,DNA_pol3_gamma3,DNA_pol3_tau_4,DNA_pol3_tau_5 k59_684380_1 991905.SL003B_2890 1.77e-30 120.0 COG1123@1|root,COG4172@2|Bacteria,1MU09@1224|Proteobacteria,2TQP0@28211|Alphaproteobacteria,4BPA1@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria P Oligopeptide/dipeptide transporter, C-terminal region gsiA1 - - ko:K02031,ko:K02032,ko:K13896 ko02010,ko02024,map02010,map02024 M00239,M00349 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5,3.A.1.5.21,3.A.1.5.24 - - ABC_tran,oligo_HPY k59_514620_1 1121921.KB898706_gene2936 1.19e-46 163.0 COG0633@1|root,COG1018@1|root,COG0633@2|Bacteria,COG1018@2|Bacteria,1QX7I@1224|Proteobacteria,1T4B5@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Oxidoreductase FAD-binding domain - - - - - - - - - - - - FAD_binding_6,Fer2,NAD_binding_1 k59_514620_2 1415778.JQMM01000001_gene104 5.3e-10 60.8 COG0668@1|root,COG0668@2|Bacteria,1N66N@1224|Proteobacteria,1RQWI@1236|Gammaproteobacteria,1J5R8@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Mechanosensitive ion channel - - - - - - - - - - - - MS_channel k59_176049_1 863365.XHC_0244 1.24e-31 124.0 COG1181@1|root,COG1181@2|Bacteria,1MUTB@1224|Proteobacteria,1RMTM@1236|Gammaproteobacteria,1XA8S@135614|Xanthomonadales 135614|Xanthomonadales F Belongs to the D-alanine--D-alanine ligase family - - 6.3.2.4 ko:K01921 ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502 - R01150 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Dala_Dala_lig_C,Dala_Dala_lig_N k59_176049_2 298653.Franean1_0147 3.32e-15 77.8 COG0546@1|root,COG1606@1|root,COG0546@2|Bacteria,COG1606@2|Bacteria,2GPA1@201174|Actinobacteria,4EUBD@85013|Frankiales 201174|Actinobacteria S PFAM ExsB family protein - - - ko:K06864 - - - - ko00000 - - - Asn_synthase,HAD,HAD_2,Hydrolase_like,NAD_synthase,QueC k59_1306351_1 391625.PPSIR1_01909 1.21e-11 70.1 COG2027@1|root,COG2027@2|Bacteria,1MW40@1224|Proteobacteria,42UDC@68525|delta/epsilon subdivisions,2X5AW@28221|Deltaproteobacteria,2Z34Y@29|Myxococcales 28221|Deltaproteobacteria M D-alanyl-D-alanine carboxypeptidase dacB - 3.4.16.4 ko:K07259 ko00550,map00550 - - - ko00000,ko00001,ko01000,ko01002,ko01011 - - - Peptidase_S13 k59_1249465_1 247634.GPB2148_822 2.21e-75 252.0 COG2937@1|root,COG2937@2|Bacteria,1MWZ6@1224|Proteobacteria,1RM7K@1236|Gammaproteobacteria,1J527@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria I Belongs to the GPAT DAPAT family plsB - 2.3.1.15 ko:K00631 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R00851,R09380 RC00004,RC00039,RC00041 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Acyltransferase k59_120070_2 351607.Acel_1073 1.75e-10 63.2 COG0134@1|root,COG0134@2|Bacteria,2GIVV@201174|Actinobacteria,4ERMN@85013|Frankiales 201174|Actinobacteria E Belongs to the TrpC family trpC GO:0000162,GO:0000287,GO:0003674,GO:0003824,GO:0004425,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016020,GO:0016053,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019752,GO:0030312,GO:0034641,GO:0040007,GO:0042401,GO:0042430,GO:0042435,GO:0043167,GO:0043169,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046219,GO:0046391,GO:0046394,GO:0046483,GO:0046872,GO:0071704,GO:0071944,GO:1901135,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.1.1.48 ko:K01609 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R03508 RC00944 ko00000,ko00001,ko00002,ko01000 - - - IGPS k59_1024228_1 1280680.AUJU01000023_gene2556 1.26e-06 51.6 COG0318@1|root,COG0318@2|Bacteria,1TPSX@1239|Firmicutes,248JC@186801|Clostridia,4BYGM@830|Butyrivibrio 186801|Clostridia IQ AMP-binding enzyme C-terminal domain - - - ko:K00666 - - - - ko00000,ko01000,ko01004 - - - AMP-binding,AMP-binding_C,STAS k59_1024228_2 1120970.AUBZ01000007_gene2935 1.87e-07 55.1 COG3945@1|root,COG3945@2|Bacteria,1RM01@1224|Proteobacteria,1S7CW@1236|Gammaproteobacteria,46CD2@72275|Alteromonadaceae 1236|Gammaproteobacteria S Hemerythrin HHE cation binding domain - - - - - - - - - - - - Hemerythrin k59_289666_2 439235.Dalk_5256 1.15e-136 399.0 COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,42WT2@68525|delta/epsilon subdivisions,2WR9X@28221|Deltaproteobacteria,2MNIW@213118|Desulfobacterales 28221|Deltaproteobacteria L PFAM transposase IS116 IS110 IS902 family protein - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_458562_1 999425.HMPREF9186_00252 8.53e-21 94.0 COG2890@1|root,COG2890@2|Bacteria,1TSMA@1239|Firmicutes,4HC6W@91061|Bacilli 91061|Bacilli J Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif prmC GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0008168,GO:0008757,GO:0016740,GO:0016741,GO:0032259,GO:0044424,GO:0044444,GO:0044464 2.1.1.297 ko:K02493 - - R10806 RC00003,RC03279 ko00000,ko01000,ko03012 - - - MTS k59_684388_1 1538644.KO02_18055 7.22e-32 114.0 COG0735@1|root,COG0735@2|Bacteria,4NSES@976|Bacteroidetes 976|Bacteroidetes P Belongs to the Fur family - - - ko:K03711 - - - - ko00000,ko03000 - - - FUR k59_120074_1 187272.Mlg_1840 4.05e-47 159.0 COG2877@1|root,COG2877@2|Bacteria,1MV91@1224|Proteobacteria,1RMGQ@1236|Gammaproteobacteria,1WWZU@135613|Chromatiales 135613|Chromatiales M 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase kdsA - 2.5.1.55 ko:K01627 ko00540,ko01100,map00540,map01100 M00063 R03254 RC00435 ko00000,ko00001,ko00002,ko01000,ko01005 - - - DAHP_synth_1 k59_120074_2 937774.TEQUI_0011 3.38e-36 134.0 COG0148@1|root,COG0148@2|Bacteria,1MU1N@1224|Proteobacteria,2VH7Y@28216|Betaproteobacteria,3T1EX@506|Alcaligenaceae 28216|Betaproteobacteria G Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis eno GO:0000015,GO:0000287,GO:0003674,GO:0003824,GO:0004634,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005856,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009986,GO:0009987,GO:0016052,GO:0016053,GO:0016310,GO:0016829,GO:0016835,GO:0016836,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0032991,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042802,GO:0042866,GO:0043167,GO:0043169,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046872,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1902494 4.2.1.11 ko:K01689 ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066 M00001,M00002,M00003,M00346,M00394 R00658 RC00349 ko00000,ko00001,ko00002,ko01000,ko03019,ko04147 - - - Enolase_C,Enolase_N k59_854481_1 684719.HIMB114_00009780 8.3e-73 229.0 COG0226@1|root,COG0226@2|Bacteria,1MUH9@1224|Proteobacteria,2TR1C@28211|Alphaproteobacteria,4BPI3@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria P PBP superfamily domain pstS - - ko:K02040 ko02010,ko02020,ko05152,map02010,map02020,map05152 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - PBP_like_2 k59_966871_1 1280944.HY17_08295 5.75e-08 61.2 COG1450@1|root,COG1450@2|Bacteria,1MUUA@1224|Proteobacteria,2TT8A@28211|Alphaproteobacteria,43WBK@69657|Hyphomonadaceae 28211|Alphaproteobacteria NU general secretion pathway protein D gspD - - ko:K02453 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - Secretin,Secretin_N k59_401993_1 172088.AUGA01000002_gene5848 1.3e-15 84.7 COG1020@1|root,COG1020@2|Bacteria,1N7HY@1224|Proteobacteria,2TRZV@28211|Alphaproteobacteria,3JSC2@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria Q Protein of unknown function (DUF1298) MA20_16710 - - - - - - - - - - - DUF1298,WES_acyltransf k59_120076_1 1123037.AUDE01000008_gene695 1.86e-06 52.0 COG0574@1|root,COG0574@2|Bacteria,4NH4R@976|Bacteroidetes,1HWKY@117743|Flavobacteriia 976|Bacteroidetes G Pyruvate phosphate dikinase - - 2.7.9.2 ko:K01007 ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200 M00173,M00374 R00199 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - PEP-utilizers,PPDK_N k59_1136416_1 316407.1651330 3.23e-53 169.0 COG0848@1|root,COG0848@2|Bacteria,1MZ6M@1224|Proteobacteria,1S8RS@1236|Gammaproteobacteria,3XPID@561|Escherichia 1236|Gammaproteobacteria U involved in the tonB-independent uptake of group A colicins tolR GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0015833,GO:0015893,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0032153,GO:0042221,GO:0042493,GO:0042886,GO:0042891,GO:0043213,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944 - ko:K03560 - - - - ko00000,ko02000 1.A.30.2.2 - - ExbD k59_1136416_2 316407.1651329 1.31e-58 186.0 COG0811@1|root,COG0811@2|Bacteria,1NCWW@1224|Proteobacteria,1RMD4@1236|Gammaproteobacteria,3XN9R@561|Escherichia 1236|Gammaproteobacteria U Involved in the TonB-independent uptake of tolQ GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0015893,GO:0016020,GO:0016021,GO:0017038,GO:0030313,GO:0031224,GO:0031226,GO:0031975,GO:0032153,GO:0033036,GO:0042221,GO:0042493,GO:0042886,GO:0042891,GO:0043213,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0050896,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944 - ko:K03562 ko01120,map01120 - - - ko00000,ko02000 1.A.30.2.2 - - MotA_ExbB k59_1757883_1 1301098.PKB_3826 7.95e-84 258.0 COG0167@1|root,COG0167@2|Bacteria,1MU7C@1224|Proteobacteria,1RMCP@1236|Gammaproteobacteria 1236|Gammaproteobacteria F Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor pyrD GO:0000166,GO:0003674,GO:0003824,GO:0004152,GO:0004158,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006206,GO:0006207,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0010181,GO:0016020,GO:0016491,GO:0016627,GO:0016634,GO:0016635,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019856,GO:0032553,GO:0034641,GO:0034654,GO:0036094,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046112,GO:0046390,GO:0046483,GO:0048037,GO:0050662,GO:0055086,GO:0055114,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 1.3.5.2 ko:K00254 ko00240,ko01100,map00240,map01100 M00051 R01868 RC00051 ko00000,ko00001,ko00002,ko01000 - - iEC042_1314.EC042_1029,iECIAI39_1322.ECIAI39_2202,iECUMN_1333.ECUMN_1134,iEcSMS35_1347.EcSMS35_2174,iPC815.YPO1415,iYL1228.KPN_00974 DHO_dh k59_684398_1 1385935.N836_18245 7.46e-50 179.0 COG0577@1|root,COG0577@2|Bacteria,1G0Z7@1117|Cyanobacteria,1H9BF@1150|Oscillatoriales 1117|Cyanobacteria V FtsX-like permease family - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_1645376_1 247634.GPB2148_1743 7.65e-112 332.0 2CEWZ@1|root,33QME@2|Bacteria,1NTHN@1224|Proteobacteria,1SKH8@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_684402_1 1122137.AQXF01000005_gene1155 1.44e-145 412.0 COG1788@1|root,COG1788@2|Bacteria,1MVEI@1224|Proteobacteria,2TTE6@28211|Alphaproteobacteria 28211|Alphaproteobacteria I COG1788 Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit scoA - 2.8.3.5 ko:K01028 ko00072,ko00280,ko00650,map00072,map00280,map00650 - R00410 RC00014 ko00000,ko00001,ko01000 - - - CoA_trans k59_402015_2 1207076.ALAT01000221_gene3516 5.53e-69 222.0 COG0213@1|root,COG0213@2|Bacteria,1MV3H@1224|Proteobacteria,1RPTG@1236|Gammaproteobacteria,1Z0BC@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria F Thymidine phosphorylase deoA GO:0003674,GO:0003824,GO:0004645,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006213,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009032,GO:0009116,GO:0009987,GO:0016740,GO:0016757,GO:0016758,GO:0016763,GO:0033554,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0055086,GO:0071704,GO:0072527,GO:1901135,GO:1901360,GO:1901564,GO:1901657 2.4.2.2,2.4.2.4 ko:K00756,ko:K00758 ko00240,ko00983,ko01100,ko05219,map00240,map00983,map01100,map05219 - R01570,R01876,R02296,R02484,R08222,R08230 RC00063 ko00000,ko00001,ko01000 - - iB21_1397.B21_04224,iEC042_1314.EC042_4879,iECBD_1354.ECBD_3638,iECB_1328.ECB_04258,iECD_1391.ECD_04258,iECH74115_1262.ECH74115_5897,iECIAI1_1343.ECIAI1_4605,iECIAI39_1322.ECIAI39_4914,iECSE_1348.ECSE_4657,iECSP_1301.ECSP_5465,iECUMN_1333.ECUMN_5006,iECW_1372.ECW_m4744,iEKO11_1354.EKO11_3932,iETEC_1333.ETEC_4738,iEcE24377_1341.EcE24377A_4981,iEcSMS35_1347.EcSMS35_4931,iEcolC_1368.EcolC_3674,iG2583_1286.G2583_5242,iSSON_1240.SSON_4533,iSbBS512_1146.SbBS512_E4929,iUMNK88_1353.UMNK88_5301,iWFL_1372.ECW_m4744,iYL1228.KPN_04838,iZ_1308.Z5984,ic_1306.c5466 Glycos_trans_3N,Glycos_transf_3,PYNP_C k59_1701301_1 1158150.KB906242_gene82 1.8e-05 45.8 COG0529@1|root,COG2046@1|root,COG0529@2|Bacteria,COG2046@2|Bacteria,1MUQB@1224|Proteobacteria,1RP4Q@1236|Gammaproteobacteria 1236|Gammaproteobacteria P Belongs to the sulfate adenylyltransferase family cysC - 2.7.7.4 ko:K00958 ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130 M00176,M00596 R00529,R04929 RC02809,RC02889 ko00000,ko00001,ko00002,ko01000 - - - APS_kinase,ATP-sulfurylase,PUA_2 k59_1701301_2 519989.ECTPHS_03066 3.53e-171 489.0 COG0621@1|root,COG0621@2|Bacteria,1MURS@1224|Proteobacteria,1RMD8@1236|Gammaproteobacteria,1WWN1@135613|Chromatiales 135613|Chromatiales J Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine miaB - 2.8.4.3 ko:K06168 - - R10645,R10646,R10647 RC00003,RC00980,RC03221,RC03222 ko00000,ko01000,ko03016 - - - Radical_SAM,TRAM,UPF0004 k59_1418819_1 1229909.NSED_01895 1.3e-88 279.0 COG1404@1|root,arCOG00702@2157|Archaea,41SX3@651137|Thaumarchaeota 651137|Thaumarchaeota O Belongs to the peptidase S8 family - - - ko:K14647 ko02024,map02024 - - - ko00000,ko00001,ko01000,ko01002,ko03110 - - - PA,Peptidase_S8 k59_1701302_1 420324.KI911965_gene528 4.42e-103 333.0 COG0642@1|root,COG2199@1|root,COG4192@1|root,COG2205@2|Bacteria,COG3706@2|Bacteria,COG4192@2|Bacteria,1NRP8@1224|Proteobacteria,2TXMN@28211|Alphaproteobacteria,1JQWM@119045|Methylobacteriaceae 28211|Alphaproteobacteria T SMART PAS domain containing protein - - - - - - - - - - - - CHASE3,HATPase_c,HisKA,PAS_3,PAS_4,Response_reg k59_346143_1 555793.WSK_0533 9.22e-52 175.0 COG0201@1|root,COG0201@2|Bacteria,1MVU7@1224|Proteobacteria,2TQMT@28211|Alphaproteobacteria,2JZY0@204457|Sphingomonadales 204457|Sphingomonadales U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently secY - - ko:K03076 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5 - - SecY k59_346143_2 702113.PP1Y_AT17117 1.5e-71 219.0 COG0563@1|root,COG0563@2|Bacteria,1MXCZ@1224|Proteobacteria,2TT6A@28211|Alphaproteobacteria,2JZW8@204457|Sphingomonadales 204457|Sphingomonadales F Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism adk - 2.7.4.3 ko:K00939 ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130 M00049 R00127,R01547,R11319 RC00002 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ADK,ADK_lid k59_571336_1 948106.AWZT01000050_gene2097 1.91e-80 247.0 COG1741@1|root,COG1741@2|Bacteria,1MWIP@1224|Proteobacteria,2VHGK@28216|Betaproteobacteria,1K4AM@119060|Burkholderiaceae 28216|Betaproteobacteria S Belongs to the pirin family - - - ko:K06911 - - - - ko00000 - - - Pirin,Pirin_C k59_1024267_1 1229909.NSED_08810 5.73e-68 214.0 COG1422@1|root,arCOG02673@2157|Archaea,41SNR@651137|Thaumarchaeota 651137|Thaumarchaeota U membrane - - - - - - - - - - - - DUF106 k59_1645409_1 243090.RB6683 1.17e-148 435.0 COG0372@1|root,COG0372@2|Bacteria,2IYFN@203682|Planctomycetes 203682|Planctomycetes H citrate synthase gltA - 2.3.3.1 ko:K01647 ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00740 R00351 RC00004,RC00067 br01601,ko00000,ko00001,ko00002,ko01000 - - - Citrate_synt k59_176869_1 983544.Lacal_0459 1.12e-74 231.0 COG1131@1|root,COG1131@2|Bacteria,4NEH0@976|Bacteroidetes,1HWPM@117743|Flavobacteriia 976|Bacteroidetes V Gliding motility-associated ABC transporter ATP-binding subunit GldA gldA - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_799061_1 436308.Nmar_1489 4.66e-81 252.0 COG0016@1|root,arCOG00410@2157|Archaea,41S9U@651137|Thaumarchaeota 651137|Thaumarchaeota J Phenylalanyl-tRNA synthetase alpha subunit - - 6.1.1.20 ko:K01889 ko00970,map00970 M00359,M00360 R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_2d k59_799061_2 1229909.NSED_08190 8.51e-43 153.0 COG0072@1|root,arCOG00412@2157|Archaea,41S8M@651137|Thaumarchaeota 651137|Thaumarchaeota J phenylalanyl-tRNA synthetase, beta subunit - - 6.1.1.20 ko:K01890 ko00970,map00970 M00359,M00360 R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - B3_4,B5 k59_1758769_2 436308.Nmar_1691 5.26e-125 372.0 COG1155@1|root,arCOG00868@2157|Archaea,41SZU@651137|Thaumarchaeota 651137|Thaumarchaeota F Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit atpA - 3.6.3.14,3.6.3.15 ko:K02117 ko00190,ko01100,map00190,map01100 M00159 - - ko00000,ko00001,ko00002,ko01000 3.A.2.2,3.A.2.3 - - ATP-synt_ab,ATP-synt_ab_N,ATP-synt_ab_Xtn k59_459486_1 1279017.AQYJ01000026_gene363 4.05e-24 100.0 COG1354@1|root,COG1354@2|Bacteria,1MVCN@1224|Proteobacteria,1RNBB@1236|Gammaproteobacteria,465A1@72275|Alteromonadaceae 1236|Gammaproteobacteria D Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves scpA - - ko:K05896 - - - - ko00000,ko03036 - - - SMC_ScpA k59_459486_2 1415778.JQMM01000001_gene2027 1.53e-32 120.0 COG1386@1|root,COG1386@2|Bacteria,1PUA6@1224|Proteobacteria,1RNXE@1236|Gammaproteobacteria,1J5NC@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria D Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves scpB - - ko:K06024 - - - - ko00000,ko03036 - - - SMC_ScpB k59_7864_1 1089552.KI911559_gene1682 6.35e-87 280.0 COG3383@1|root,COG3383@2|Bacteria,1QTZB@1224|Proteobacteria,2TVZI@28211|Alphaproteobacteria,2JQ15@204441|Rhodospirillales 204441|Rhodospirillales C Formate dehydrogenase subunit alpha - - - - - - - - - - - - Fer2_4,Fer4_7,Fer4_9,Molybdop_Fe4S4,Molybdopterin,Molydop_binding k59_1476776_1 926549.KI421517_gene3249 2.54e-33 126.0 COG0738@1|root,COG0738@2|Bacteria,4NFHM@976|Bacteroidetes,47JNK@768503|Cytophagia 976|Bacteroidetes G PFAM Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 k59_1080873_1 1123228.AUIH01000002_gene1532 1.82e-82 256.0 COG0739@1|root,COG0739@2|Bacteria,1MVTF@1224|Proteobacteria,1RMIR@1236|Gammaproteobacteria,1XIFQ@135619|Oceanospirillales 135619|Oceanospirillales M peptidase - - - - - - - - - - - - Peptidase_M23 k59_799103_1 1117315.AHCA01000001_gene2617 2.64e-21 100.0 COG3501@1|root,COG4253@1|root,COG3501@2|Bacteria,COG4253@2|Bacteria,1R9SB@1224|Proteobacteria,1RYBD@1236|Gammaproteobacteria,2Q41V@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria S Phage late control gene D protein (GPD) - - - ko:K11904 ko03070,map03070 M00334 - - ko00000,ko00001,ko00002,ko02044 3.A.23.1 - - Phage_GPD k59_1702096_1 1401328.P856_569 1.29e-21 95.1 COG0564@1|root,COG0564@2|Bacteria,1MUBN@1224|Proteobacteria,2TSBK@28211|Alphaproteobacteria,2JQ4Y@204441|Rhodospirillales 204441|Rhodospirillales J Responsible for synthesis of pseudouridine from uracil rluD - 5.4.99.23 ko:K06180 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2,S4 k59_1702096_2 318464.IO99_09620 2.35e-19 89.0 COG1496@1|root,COG1496@2|Bacteria,1TS34@1239|Firmicutes,248TD@186801|Clostridia,36I6A@31979|Clostridiaceae 186801|Clostridia S Belongs to the multicopper oxidase YfiH RL5 family yfiH - - ko:K05810 - - - - ko00000,ko01000 - - - Cu-oxidase_4 k59_572231_1 502025.Hoch_3411 3.34e-107 326.0 COG0626@1|root,COG0626@2|Bacteria,1MU57@1224|Proteobacteria,42M67@68525|delta/epsilon subdivisions,2WJQX@28221|Deltaproteobacteria,2YY2Q@29|Myxococcales 28221|Deltaproteobacteria H Cys/Met metabolism PLP-dependent enzyme - - 2.5.1.48 ko:K01739 ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00270,map00450,map00920,map01100,map01110,map01130,map01230 M00017 R00999,R01288,R02508,R03217,R03260,R04944,R04945,R04946 RC00020,RC00056,RC00069,RC00420,RC02848,RC02866 ko00000,ko00001,ko00002,ko01000 - - - Cys_Met_Meta_PP k59_1307198_1 1469557.JSWF01000044_gene667 7.73e-45 153.0 2EP6X@1|root,33GTN@2|Bacteria,4NXH1@976|Bacteroidetes 976|Bacteroidetes S Protein of unknown function (DUF3575) - - - - - - - - - - - - DUF3575 k59_1080877_1 1122137.AQXF01000004_gene1857 4.36e-62 211.0 COG0457@1|root,COG0457@2|Bacteria,1MVMG@1224|Proteobacteria,2U099@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Sulfotransferase domain - - - - - - - - - - - - Sulfotransfer_3,TPR_16,TPR_2,TPR_8 k59_628894_1 1121104.AQXH01000002_gene699 9.69e-22 100.0 COG0464@1|root,COG0464@2|Bacteria 2|Bacteria O ATPase activity - - - - - - - - - - - - AAA k59_347085_1 1313172.YM304_02480 3.36e-20 89.0 COG0526@1|root,COG0526@2|Bacteria,2H8ZP@201174|Actinobacteria 201174|Actinobacteria CO Redoxin - - - - - - - - - - - - - k59_347085_2 479432.Sros_6754 6.69e-21 91.7 COG2141@1|root,COG2141@2|Bacteria,2GJ6T@201174|Actinobacteria,4EG4H@85012|Streptosporangiales 201174|Actinobacteria C Luciferase-like monooxygenase - - 1.14.14.5 ko:K04091 ko00920,map00920 - R07210,R10206 RC01779,RC02556 ko00000,ko00001,ko01000 - - - Bac_luciferase k59_1758805_1 1128421.JAGA01000003_gene2818 2.1e-61 202.0 COG0517@1|root,COG1994@1|root,COG0517@2|Bacteria,COG1994@2|Bacteria,2NPE1@2323|unclassified Bacteria 2|Bacteria S Peptidase family M50 rip3 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 - ko:K06212,ko:K06402 - - - - ko00000,ko01000,ko01002,ko02000 1.A.16.1.1,1.A.16.1.3 - - CBS,Form_Nir_trans,Peptidase_M50 k59_1702103_1 436308.Nmar_1031 2.29e-07 52.0 arCOG08678@1|root,arCOG08678@2157|Archaea,41SR1@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1702103_2 1229909.NSED_06075 1.06e-13 66.6 arCOG10406@1|root,arCOG10406@2157|Archaea,41SVU@651137|Thaumarchaeota 651137|Thaumarchaeota S Zinc finger, C2H2 type - - - - - - - - - - - - zf-C2H2 k59_1702103_3 436308.Nmar_1032 4.4e-37 125.0 COG1996@1|root,arCOG04341@2157|Archaea,41SWH@651137|Thaumarchaeota 651137|Thaumarchaeota K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates - - 2.7.7.6 ko:K03059 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00184 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021 - - - - k59_1250418_1 1218084.BBJK01000027_gene2636 6.22e-10 65.9 COG0658@1|root,COG2333@1|root,COG0658@2|Bacteria,COG2333@2|Bacteria,1MUKF@1224|Proteobacteria,2VHKP@28216|Betaproteobacteria,1JZT5@119060|Burkholderiaceae 28216|Betaproteobacteria S Competence protein ComEC comA - - ko:K02238 - M00429 - - ko00000,ko00002,ko02044 3.A.11.1,3.A.11.2 - - Competence,DUF4131,Lactamase_B k59_402977_1 1322246.BN4_12655 5.83e-71 230.0 COG0380@1|root,COG0380@2|Bacteria,1MUIY@1224|Proteobacteria,42NBU@68525|delta/epsilon subdivisions,2WJX9@28221|Deltaproteobacteria,2MA96@213115|Desulfovibrionales 28221|Deltaproteobacteria G PFAM Glycosyl transferase, family 20 otsAB - 2.4.1.15,2.4.1.347,3.1.3.12 ko:K00697,ko:K16055 ko00500,ko01100,map00500,map01100 - R02737,R02778 RC00005,RC00017,RC00049,RC02748 ko00000,ko00001,ko01000,ko01003 - GT20 - Glyco_transf_20,S6PP,Trehalose_PPase k59_1307214_1 1122137.AQXF01000003_gene2423 4.86e-17 82.0 COG5388@1|root,COG5388@2|Bacteria,1Q47N@1224|Proteobacteria,2UME7@28211|Alphaproteobacteria 28211|Alphaproteobacteria S PAS domain - - - - - - - - - - - - PAS_5 k59_1476804_1 1229909.NSED_01670 1.75e-52 183.0 COG0085@1|root,arCOG01762@2157|Archaea,41SF5@651137|Thaumarchaeota 651137|Thaumarchaeota K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates - - 2.7.7.6 ko:K13798 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00184 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021 - - - RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_4,RNA_pol_Rpb2_5,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7 k59_1476804_2 1229909.NSED_01675 1.52e-67 227.0 COG0086@1|root,arCOG04256@2157|Archaea,arCOG04257@2157|Archaea,41SB2@651137|Thaumarchaeota 651137|Thaumarchaeota K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoA2 - 2.7.7.6 ko:K03041 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00184 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021 - - - RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5 k59_685260_1 1123035.ARLA01000028_gene2530 2.94e-42 157.0 COG3188@1|root,COG3188@2|Bacteria,4NHVA@976|Bacteroidetes,1I7AS@117743|Flavobacteriia 976|Bacteroidetes NU usher protein - - - - - - - - - - - - - k59_347123_1 1056820.KB900674_gene2658 1.66e-11 65.9 COG1629@1|root,COG1629@2|Bacteria,COG4771@2|Bacteria,1MV8W@1224|Proteobacteria,1RMQA@1236|Gammaproteobacteria,2PN5Q@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria P TonB dependent receptor - - - - - - - - - - - - Plug,TonB_dep_Rec k59_347123_2 1121124.JNIX01000001_gene983 3.82e-59 199.0 COG2272@1|root,COG2272@2|Bacteria,1MVQZ@1224|Proteobacteria,2TTHT@28211|Alphaproteobacteria,2KFIK@204458|Caulobacterales 204458|Caulobacterales I Belongs to the type-B carboxylesterase lipase family - - - ko:K03929 - - - - ko00000,ko01000 - CE10 - COesterase k59_1193998_1 1229909.NSED_08245 2.6e-82 244.0 arCOG08677@1|root,arCOG08677@2157|Archaea,41SVJ@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1193998_2 1131266.ARWQ01000001_gene1136 4.23e-10 60.1 arCOG03932@1|root,arCOG03932@2157|Archaea,41SKB@651137|Thaumarchaeota 651137|Thaumarchaeota K Cobalamin B12-binding domain protein - - - - - - - - - - - - - k59_120969_1 1388763.O165_003840 1.11e-39 141.0 COG1943@1|root,COG1943@2|Bacteria,1PJ9C@1224|Proteobacteria,1TM6V@1236|Gammaproteobacteria,1YZ5E@136845|Pseudomonas putida group 1236|Gammaproteobacteria L Transposase IS200 like - - - ko:K07491 - - - - ko00000 - - - Y1_Tnp k59_1646284_1 1121434.AULY01000009_gene2266 2.25e-25 109.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,42M0W@68525|delta/epsilon subdivisions,2WIK8@28221|Deltaproteobacteria,2M8CQ@213115|Desulfovibrionales 28221|Deltaproteobacteria T Diguanylate cyclase phosphodiesterase with PAS PAC sensor(S) - - - - - - - - - - - - EAL,GGDEF,Response_reg k59_911691_1 981369.JQMJ01000004_gene2951 6.98e-33 124.0 COG0428@1|root,COG0428@2|Bacteria,2IBHZ@201174|Actinobacteria,2NHVS@228398|Streptacidiphilus 201174|Actinobacteria P ZIP Zinc transporter - - - ko:K07238 - - - - ko00000,ko02000 2.A.5.5 - - Zip k59_1476822_1 1137281.D778_01459 2.24e-61 194.0 COG3279@1|root,COG3279@2|Bacteria,4NI3K@976|Bacteroidetes,1HZ0N@117743|Flavobacteriia 976|Bacteroidetes T Response regulator of the LytR AlgR family - - - ko:K02477 - - - - ko00000,ko02022 - - - LytTR,Response_reg k59_1476822_2 1122225.AULQ01000007_gene2337 1.55e-61 200.0 COG0508@1|root,COG0508@2|Bacteria,4NED0@976|Bacteroidetes,1HWW8@117743|Flavobacteriia 976|Bacteroidetes C dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex bfmBB - 2.3.1.61 ko:K00658 ko00020,ko00310,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00032 R02570,R02571,R08549 RC00004,RC02727,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - 2-oxoacid_dh,Biotin_lipoyl,E3_binding k59_578895_2 448385.sce6471 3.73e-50 171.0 COG0278@1|root,COG0316@1|root,COG0607@1|root,COG0278@2|Bacteria,COG0316@2|Bacteria,COG0607@2|Bacteria,1MZ4V@1224|Proteobacteria,43154@68525|delta/epsilon subdivisions,2WWCI@28221|Deltaproteobacteria,2YVCT@29|Myxococcales 28221|Deltaproteobacteria C Belongs to the glutaredoxin family. Monothiol subfamily - - - ko:K07390 - - - - ko00000,ko03029,ko03110 - - - Glutaredoxin,Rhodanese k59_578901_2 207954.MED92_14333 2.49e-56 189.0 COG0161@1|root,COG0161@2|Bacteria,1MU2N@1224|Proteobacteria,1RP0C@1236|Gammaproteobacteria,1XHQT@135619|Oceanospirillales 135619|Oceanospirillales E Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family - - 2.6.1.18 ko:K00822 ko00280,ko00410,ko00640,ko01100,map00280,map00410,map00640,map01100 - R00907,R04187 RC00008,RC00062,RC00160 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_3 k59_409472_1 219305.MCAG_02268 2.29e-30 116.0 COG0596@1|root,COG0596@2|Bacteria,2GNFU@201174|Actinobacteria,4DDT0@85008|Micromonosporales 201174|Actinobacteria S alpha/beta hydrolase fold - - - - - - - - - - - - Abhydrolase_1,Abhydrolase_6 k59_748114_1 983920.Y88_3198 2.5e-55 177.0 COG1376@1|root,COG1376@2|Bacteria,1RKB2@1224|Proteobacteria,2UAA8@28211|Alphaproteobacteria,2K4DR@204457|Sphingomonadales 204457|Sphingomonadales S L,D-transpeptidase catalytic domain - - - - - - - - - - - - YkuD_2 k59_183785_1 338963.Pcar_3001 3.42e-70 238.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MQ0@68525|delta/epsilon subdivisions,2WJ2A@28221|Deltaproteobacteria,43SE5@69541|Desulfuromonadales 28221|Deltaproteobacteria V AcrB/AcrD/AcrF family - - - - - - - - - - - - ACR_tran k59_1256834_2 1229909.NSED_01685 9.89e-128 375.0 arCOG08777@1|root,arCOG08800@1|root,arCOG08777@2157|Archaea,arCOG08800@2157|Archaea 2157|Archaea L metallopeptidase activity - - - - - - - - - - - - CHB_HEX_C_1,Polysacc_deac_1 k59_1143661_1 702113.PP1Y_Mpl6736 8.59e-59 194.0 COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2TQR1@28211|Alphaproteobacteria,2JZVD@204457|Sphingomonadales 204457|Sphingomonadales C belongs to the aldehyde dehydrogenase family - - - - - - - - - - - - Aldedh k59_1143661_2 1248760.ANFZ01000019_gene1753 5.62e-17 79.7 COG1062@1|root,COG1062@2|Bacteria,1MUK4@1224|Proteobacteria,2TUMG@28211|Alphaproteobacteria,2K338@204457|Sphingomonadales 204457|Sphingomonadales C Alcohol dehydrogenase GroES-like domain - - 1.1.1.90 ko:K00055 ko00350,ko00360,ko00622,ko00623,ko01100,ko01120,ko01220,map00350,map00360,map00622,map00623,map01100,map01120,map01220 M00537,M00538 R01763,R02611,R04304,R05282,R05347,R05348 RC00087,RC00116 ko00000,ko00001,ko00002,ko01000 - - - ADH_N,ADH_zinc_N k59_917951_1 1122137.AQXF01000001_gene3390 1.25e-111 328.0 COG3176@1|root,COG3176@2|Bacteria,1MWIM@1224|Proteobacteria,2TUVA@28211|Alphaproteobacteria 28211|Alphaproteobacteria S hemolysin olsB - 2.3.2.30 ko:K22310 - - - - ko00000,ko01000 - - - Acetyltransf_5 k59_1200536_1 1173027.Mic7113_2362 3.83e-66 209.0 COG3128@1|root,COG3128@2|Bacteria,1G0QX@1117|Cyanobacteria,1HAKV@1150|Oscillatoriales 1117|Cyanobacteria C PKHD-type hydroxylase piuC - - ko:K07336 - - - - ko00000,ko01000 - - - 2OG-FeII_Oxy_3 k59_465839_1 298386.PBPRA0583 0.000208 43.1 COG3004@1|root,COG3004@2|Bacteria,1MW15@1224|Proteobacteria,1RNDE@1236|Gammaproteobacteria,1XT58@135623|Vibrionales 135623|Vibrionales P ) H( ) antiporter that extrudes sodium in exchange for external protons nhaA GO:0003674,GO:0005215,GO:0005451,GO:0006810,GO:0006811,GO:0006812,GO:0006814,GO:0008150,GO:0008324,GO:0015075,GO:0015077,GO:0015078,GO:0015081,GO:0015291,GO:0015297,GO:0015298,GO:0015299,GO:0015318,GO:0015385,GO:0015491,GO:0015672,GO:0022804,GO:0022857,GO:0022890,GO:0030001,GO:0034220,GO:0035725,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0098655,GO:0098660,GO:0098662,GO:0099516,GO:1902600 - ko:K03313 - - - - ko00000,ko02000 2.A.33.1 - - Na_H_antiport_1 k59_465839_2 1121374.KB891588_gene3351 1.43e-60 193.0 COG1670@1|root,COG1670@2|Bacteria,1MXEE@1224|Proteobacteria,1S2G5@1236|Gammaproteobacteria 1236|Gammaproteobacteria J Acetyltransferases including N-acetylases of ribosomal proteins ydaF_1 - - - - - - - - - - - Acetyltransf_1,Acetyltransf_3 k59_1313995_2 1122137.AQXF01000001_gene3106 1.69e-262 723.0 COG0820@1|root,COG0820@2|Bacteria,1MUYK@1224|Proteobacteria,2TQT3@28211|Alphaproteobacteria 28211|Alphaproteobacteria J Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs rlmN GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0022613,GO:0030488,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140101,GO:0140102,GO:1901360 2.1.1.192 ko:K06941 - - - - ko00000,ko01000,ko03009 - - - Radical_SAM k59_1313995_3 1121949.AQXT01000002_gene2067 8.39e-25 104.0 COG1835@1|root,COG1835@2|Bacteria,1R4CU@1224|Proteobacteria,2U2AF@28211|Alphaproteobacteria,43WPC@69657|Hyphomonadaceae 28211|Alphaproteobacteria I Acyltransferase family - - - - - - - - - - - - Acyl_transf_3 k59_1370524_1 1229909.NSED_09015 1.98e-178 518.0 COG1269@1|root,arCOG04138@2157|Archaea,41SRH@651137|Thaumarchaeota 651137|Thaumarchaeota C Belongs to the V-ATPase 116 kDa subunit family - - - ko:K02123 ko00190,ko01100,map00190,map01100 M00159 - - ko00000,ko00001,ko00002 3.A.2.2,3.A.2.3 - - V_ATPase_I k59_1426120_1 614083.AWQR01000034_gene3572 1.39e-82 260.0 COG1032@1|root,COG1032@2|Bacteria,1Q5NG@1224|Proteobacteria,2VPEG@28216|Betaproteobacteria,4AGU0@80864|Comamonadaceae 28216|Betaproteobacteria C Protein of unknown function (DUF4080) - - - - - - - - - - - - B12-binding,DUF4080,Radical_SAM k59_1313999_1 1122137.AQXF01000002_gene84 5.73e-95 298.0 COG2185@1|root,COG2185@2|Bacteria,1QU3N@1224|Proteobacteria,2TVY1@28211|Alphaproteobacteria 28211|Alphaproteobacteria I Methylmalonyl-CoA mutase - - 5.4.99.2 ko:K01847 ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200 M00373,M00376,M00741 R00833 RC00395 ko00000,ko00001,ko00002,ko01000 - - - B12-binding,MM_CoA_mutase k59_465845_1 523791.Kkor_0597 2.35e-75 244.0 COG3808@1|root,COG3808@2|Bacteria,1MUQ3@1224|Proteobacteria,1RN4K@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force hppA - 3.6.1.1 ko:K15987 ko00190,map00190 - - - ko00000,ko00001,ko01000 3.A.10.1 - - H_PPase k59_521961_2 1216966.BAUC01000009_gene2168 1.45e-40 142.0 COG0584@1|root,COG0584@2|Bacteria,1MU8H@1224|Proteobacteria,1RQWX@1236|Gammaproteobacteria 1236|Gammaproteobacteria C glycerophosphoryl diester phosphodiesterase ugpQ GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0008081,GO:0008889,GO:0016787,GO:0016788,GO:0042578,GO:0043167,GO:0043169,GO:0046872,GO:0047389,GO:0047395 3.1.4.46 ko:K01126 ko00564,map00564 - R01030,R01470 RC00017,RC00425 ko00000,ko00001,ko01000 - - iEC042_1314.EC042_3710,iEC55989_1330.EC55989_3857 GDPD k59_1766555_2 436308.Nmar_1393 2.52e-80 243.0 COG0164@1|root,arCOG04121@2157|Archaea,41SK9@651137|Thaumarchaeota 651137|Thaumarchaeota L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids rnhB - 3.1.26.4 ko:K03470 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - RNase_HII k59_1597047_2 1219031.BBJR01000055_gene2003 8.22e-42 144.0 COG1664@1|root,COG1664@2|Bacteria,1N26P@1224|Proteobacteria,2VSIS@28216|Betaproteobacteria,4AE27@80864|Comamonadaceae 28216|Betaproteobacteria M Polymer-forming cytoskeletal - - - - - - - - - - - - Bactofilin k59_522975_1 553385.JEMF01000078_gene651 3.04e-51 177.0 COG0173@1|root,COG0173@2|Bacteria,1MUXB@1224|Proteobacteria,1RNMI@1236|Gammaproteobacteria,1XH85@135619|Oceanospirillales 135619|Oceanospirillales J Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) aspS - 6.1.1.12 ko:K01876 ko00970,map00970 M00359,M00360 R05577 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - GAD,tRNA-synt_2,tRNA_anti-codon k59_522975_2 713586.KB900536_gene1058 1.38e-06 49.7 COG2928@1|root,COG2928@2|Bacteria,1MWT5@1224|Proteobacteria,1S3MU@1236|Gammaproteobacteria,1X29U@135613|Chromatiales 135613|Chromatiales S Protein of unknown function (DUF502) - - - - - - - - - - - - DUF502 k59_974852_2 1415778.JQMM01000001_gene1403 1.44e-48 163.0 COG3165@1|root,COG3165@2|Bacteria,1R1CM@1224|Proteobacteria,1S1SM@1236|Gammaproteobacteria,1J6XG@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S protein conserved in bacteria yigP - - ko:K03690 - - - - ko00000 - - - SCP2 k59_1710010_1 1479239.JQMU01000001_gene1712 0.000138 42.7 COG1558@1|root,COG1558@2|Bacteria,1RHI3@1224|Proteobacteria,2U94I@28211|Alphaproteobacteria,2K5CH@204457|Sphingomonadales 204457|Sphingomonadales N Belongs to the flagella basal body rod proteins family flgC - - ko:K02388 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - Flg_bb_rod,Flg_bbr_C k59_1710010_3 1096930.L284_06635 8.01e-29 110.0 COG4786@1|root,COG4786@2|Bacteria,1NSEC@1224|Proteobacteria,2U418@28211|Alphaproteobacteria,2K0W9@204457|Sphingomonadales 204457|Sphingomonadales N flagellar basal body flgE - - ko:K02390 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - Flg_bb_rod,Flg_bbr_C k59_15411_1 398527.Bphyt_0528 9.5e-67 213.0 COG0189@1|root,COG0189@2|Bacteria,1MVUA@1224|Proteobacteria,2VIZ3@28216|Betaproteobacteria,1K2PI@119060|Burkholderiaceae 28216|Betaproteobacteria H Belongs to the prokaryotic GSH synthase family gshB - 6.3.2.3 ko:K01920 ko00270,ko00480,ko01100,map00270,map00480,map01100 M00118 R00497,R10994 RC00096,RC00141 ko00000,ko00001,ko00002,ko01000 - - - GSH-S_ATP,GSH-S_N k59_15411_2 85643.Tmz1t_0469 1.32e-22 91.7 COG2893@1|root,COG2893@2|Bacteria,1RHH7@1224|Proteobacteria,2VT9I@28216|Betaproteobacteria,2KWTC@206389|Rhodocyclales 206389|Rhodocyclales G Phosphotransferase system, mannose fructose-specific component IIA ptsL - 2.7.1.194 ko:K02821 ko00053,ko01100,ko01120,ko02060,map00053,map01100,map01120,map02060 M00283,M00550 R07671 RC00017,RC03206 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.7.1 - - EIIA-man k59_1597057_1 285514.JNWO01000003_gene6899 0.000621 48.1 COG2197@1|root,COG3899@1|root,COG2197@2|Bacteria,COG3899@2|Bacteria,2I2R1@201174|Actinobacteria 201174|Actinobacteria K regulatory protein LuxR - - - - - - - - - - - - AAA_16,GerE k59_1257876_1 1089552.KI911559_gene2914 3.74e-47 172.0 COG2931@1|root,COG2982@1|root,COG4932@1|root,COG2931@2|Bacteria,COG2982@2|Bacteria,COG4932@2|Bacteria,1MU7T@1224|Proteobacteria,2TRVY@28211|Alphaproteobacteria,2JZKC@204441|Rhodospirillales 204441|Rhodospirillales MQU Dystroglycan-type cadherin-like domains. - - - - - - - - - - - - DUF4347 k59_1766568_1 595460.RRSWK_03632 0.000425 44.7 COG3119@1|root,COG3119@2|Bacteria,2IWSZ@203682|Planctomycetes 203682|Planctomycetes P COG3119 Arylsulfatase A - - - - - - - - - - - - Sulfatase k59_1597062_1 504487.JCM19302_3737 1.8e-18 84.7 COG0308@1|root,COG0308@2|Bacteria,4NE13@976|Bacteroidetes,1HWXD@117743|Flavobacteriia 976|Bacteroidetes E aminopeptidase - - - - - - - - - - - - Peptidase_M1 k59_1597062_2 1296416.JACB01000015_gene4825 5.62e-21 91.3 COG3808@1|root,COG3808@2|Bacteria,4NF2I@976|Bacteroidetes,1HWN8@117743|Flavobacteriia,2YH8J@290174|Aquimarina 976|Bacteroidetes C Inorganic H+ pyrophosphatase hppA - 3.6.1.1 ko:K15987 ko00190,map00190 - - - ko00000,ko00001,ko01000 3.A.10.1 - - H_PPase,OmpA k59_185130_1 485913.Krac_0569 4.64e-32 124.0 COG2017@1|root,COG2017@2|Bacteria,2G7BC@200795|Chloroflexi 200795|Chloroflexi G converts alpha-aldose to the beta-anomer - - - - - - - - - - - - DUF5107 k59_1201853_1 998674.ATTE01000001_gene3580 7.14e-32 122.0 COG0805@1|root,COG0805@2|Bacteria,1MVAY@1224|Proteobacteria,1RPRN@1236|Gammaproteobacteria,45ZPS@72273|Thiotrichales 72273|Thiotrichales U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides tatC - - ko:K03118 ko03060,ko03070,map03060,map03070 M00336 - - ko00000,ko00001,ko00002,ko02044 2.A.64 - - TatC k59_522982_1 1121405.dsmv_0646 1.11e-64 210.0 COG5660@1|root,2Z7TM@2|Bacteria,1PMCV@1224|Proteobacteria,42Q81@68525|delta/epsilon subdivisions,2WIJ3@28221|Deltaproteobacteria,2MJ76@213118|Desulfobacterales 28221|Deltaproteobacteria S TRAP transporter T-component - - - - - - - - - - - - TAtT k59_1257879_1 395494.Galf_0608 7.96e-81 249.0 COG1211@1|root,COG1211@2|Bacteria,1MY3B@1224|Proteobacteria,2VMD6@28216|Betaproteobacteria,44VGQ@713636|Nitrosomonadales 28216|Betaproteobacteria I Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) ispD - 2.7.7.60,4.6.1.12 ko:K00991,ko:K12506 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05633,R05637 RC00002,RC01440 ko00000,ko00001,ko00002,ko01000 - - - IspD k59_1257879_2 1280682.AUKA01000001_gene1968 5.15e-38 132.0 COG0245@1|root,COG0245@2|Bacteria,1V3P0@1239|Firmicutes,24HCM@186801|Clostridia,4BX0E@830|Butyrivibrio 186801|Clostridia I Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) ispF - 2.7.7.60,4.6.1.12 ko:K01770,ko:K12506 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05633,R05637 RC00002,RC01440 ko00000,ko00001,ko00002,ko01000 - - - IspD,YgbB k59_354963_1 1267535.KB906767_gene4070 5.07e-23 97.4 COG3570@1|root,COG3570@2|Bacteria 2|Bacteria V aminoglycoside hydroxyurea antibiotic resistance kinase strB - 2.7.1.72 ko:K04343 - M00766 R02225 RC00002,RC00078 br01600,ko00000,ko00002,ko01000,ko01504 - - - APH_6_hur k59_1314973_1 446468.Ndas_3101 3.43e-22 97.1 COG0543@1|root,COG0543@2|Bacteria,2HQ24@201174|Actinobacteria,4EG48@85012|Streptosporangiales 201174|Actinobacteria CH Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B pyrK - - ko:K02823 ko00240,ko01100,map00240,map01100 - - - ko00000,ko00001 - - - DHODB_Fe-S_bind,FAD_binding_6,NAD_binding_1 k59_1314973_2 411464.DESPIG_02027 5.68e-101 305.0 COG0167@1|root,COG0167@2|Bacteria,1MU7C@1224|Proteobacteria,42M46@68525|delta/epsilon subdivisions,2WJ7G@28221|Deltaproteobacteria,2M8K5@213115|Desulfovibrionales 28221|Deltaproteobacteria F Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily pyrD GO:0003674,GO:0003824,GO:0004152,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006206,GO:0006207,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016491,GO:0016627,GO:0016635,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019856,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046112,GO:0046390,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 1.3.1.14,1.3.5.2 ko:K00254,ko:K02823,ko:K17828 ko00240,ko01100,map00240,map01100 M00051 R01868,R01869 RC00051 ko00000,ko00001,ko00002,ko01000 - - - DHO_dh k59_466915_1 981384.AEYW01000001_gene1705 8.59e-98 294.0 COG0435@1|root,COG0435@2|Bacteria,1MV50@1224|Proteobacteria,2TRDE@28211|Alphaproteobacteria,4NAR2@97050|Ruegeria 28211|Alphaproteobacteria O Glutathione S-transferase, C-terminal domain yqjG GO:0003674,GO:0003824,GO:0004364,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0016491,GO:0016667,GO:0016672,GO:0016740,GO:0016765,GO:0042221,GO:0044424,GO:0044464,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1990748 1.8.5.7 ko:K07393 - - - - ko00000,ko01000 - - - GST_C_2,GST_N_2 k59_185144_1 667632.KB890217_gene4870 6.78e-82 260.0 COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,2VH16@28216|Betaproteobacteria,1K3N3@119060|Burkholderiaceae 28216|Betaproteobacteria JKL DEAD-box RNA helicase involved in ribosome assembly. Has RNA-dependent ATPase activity and unwinds double-stranded RNA rhlE GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008026,GO:0008104,GO:0008150,GO:0008186,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032991,GO:0033036,GO:0035770,GO:0036464,GO:0042623,GO:0043186,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044424,GO:0044444,GO:0044464,GO:0045495,GO:0051179,GO:0060293,GO:0070035,GO:0140098,GO:1990904 3.6.4.13 ko:K11927 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - DEAD,Helicase_C k59_1710046_1 278957.ABEA03000060_gene3151 4.52e-24 99.4 COG0115@1|root,COG0115@2|Bacteria,46S9W@74201|Verrucomicrobia,3K7I4@414999|Opitutae 414999|Opitutae E Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family ilvE - 2.6.1.42 ko:K00826 ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00036,M00119,M00570 R01090,R01214,R02199,R10991 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_4 k59_354979_1 316407.85676681 1.24e-62 202.0 COG4992@1|root,COG4992@2|Bacteria,1MV3C@1224|Proteobacteria,1RMV1@1236|Gammaproteobacteria,3XPBV@561|Escherichia 1236|Gammaproteobacteria E Involved in both the arginine and lysine biosynthetic pathways argD GO:0003674,GO:0003824,GO:0003992,GO:0004069,GO:0005488,GO:0005515,GO:0006082,GO:0006105,GO:0006520,GO:0006525,GO:0006526,GO:0006527,GO:0006553,GO:0006591,GO:0006593,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009016,GO:0009056,GO:0009058,GO:0009063,GO:0009064,GO:0009065,GO:0009066,GO:0009067,GO:0009084,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016054,GO:0016740,GO:0016769,GO:0017144,GO:0019545,GO:0019752,GO:0019842,GO:0030170,GO:0033359,GO:0036094,GO:0042450,GO:0042802,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0043825,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044281,GO:0044282,GO:0044283,GO:0046394,GO:0046395,GO:0046451,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1901607 2.6.1.11,2.6.1.17,2.6.1.81 ko:K00821,ko:K00840 ko00220,ko00300,ko00330,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map00330,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00028,M00845 R02283,R04217,R04475 RC00006,RC00062 ko00000,ko00001,ko00002,ko01000,ko01007 - - iEC55989_1330.EC55989_1916,iSFV_1184.SFV_3365,iSF_1195.SF3378,iSFxv_1172.SFxv_3689,iSSON_1240.SSON_3490,iS_1188.S4385 Aminotran_3 k59_354979_2 316407.85676680 1.49e-68 210.0 COG0512@1|root,COG0512@2|Bacteria,1MV5Y@1224|Proteobacteria,1RMQW@1236|Gammaproteobacteria,3XN45@561|Escherichia 1236|Gammaproteobacteria EH Part of a heterodimeric complex that catalyzes the two- step biosynthesis of 4-amino-4-deoxychorismate (ADC), a precursor of p-aminobenzoate (PABA) and tetrahydrofolate. In the first step, a glutamine amidotransferase (PabA) generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by aminodeoxychorismate synthase (PabB) to produce ADC. PabA converts glutamine into glutamate only in the presence of stoichiometric amounts of PabB pabA GO:0000162,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005950,GO:0006082,GO:0006520,GO:0006568,GO:0006575,GO:0006576,GO:0006586,GO:0006725,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009108,GO:0009308,GO:0009309,GO:0009396,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0018130,GO:0019438,GO:0019752,GO:0032991,GO:0034641,GO:0042398,GO:0042401,GO:0042430,GO:0042435,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0046653,GO:0046654,GO:0046820,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494 2.6.1.85,4.1.3.27 ko:K01658,ko:K01664 ko00400,ko00405,ko00790,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map00790,map01100,map01110,map01130,map01230,map02024,map02025 M00023 R00985,R00986,R01716 RC00010,RC01418,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 - - iAPECO1_1312.APECO1_3095,iEC042_1314.EC042_3623,iECABU_c1320.ECABU_c37840,iECED1_1282.ECED1_4024,iECNA114_1301.ECNA114_3463,iECOK1_1307.ECOK1_3780,iECP_1309.ECP_3451,iECS88_1305.ECS88_3751,iECSF_1327.ECSF_3187,iLF82_1304.LF82_1586,iNRG857_1313.NRG857_16660,iUMN146_1321.UM146_16880,iUTI89_1310.UTI89_C3863,ic_1306.c4135 GATase k59_410557_1 396588.Tgr7_1439 8.82e-87 268.0 COG0460@1|root,COG0460@2|Bacteria,1MUDC@1224|Proteobacteria,1RPEU@1236|Gammaproteobacteria,1WWHB@135613|Chromatiales 135613|Chromatiales E homoserine dehydrogenase - - 1.1.1.3 ko:K00003 ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230 M00017,M00018 R01773,R01775 RC00087 ko00000,ko00001,ko00002,ko01000 - - - ACT,Homoserine_dh,NAD_binding_3 k59_749472_1 483219.LILAB_16930 6.07e-07 51.2 COG1396@1|root,COG1396@2|Bacteria,1NGM7@1224|Proteobacteria,435V2@68525|delta/epsilon subdivisions,2X0AM@28221|Deltaproteobacteria,2Z0JA@29|Myxococcales 28221|Deltaproteobacteria K Cro/C1-type HTH DNA-binding domain - - - - - - - - - - - - HTH_3 k59_1257893_1 493475.GARC_3364 1.42e-12 69.3 2ECN7@1|root,32Y4C@2|Bacteria,1NEKK@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_1257893_2 1479238.JQMZ01000001_gene1493 3.01e-11 69.7 2ECN7@1|root,31C3K@2|Bacteria,1Q81Z@1224|Proteobacteria,2V92U@28211|Alphaproteobacteria,4406R@69657|Hyphomonadaceae 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_693078_1 1123399.AQVE01000004_gene2516 2.95e-107 317.0 COG0113@1|root,COG0113@2|Bacteria,1MWMW@1224|Proteobacteria,1RP6Q@1236|Gammaproteobacteria,45ZPX@72273|Thiotrichales 72273|Thiotrichales H Belongs to the ALAD family - - 4.2.1.24 ko:K01698 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R00036 RC00918,RC01781 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ALAD k59_693078_2 1123228.AUIH01000007_gene2573 4.28e-20 89.0 COG0169@1|root,COG0169@2|Bacteria,1MVH4@1224|Proteobacteria,1RPB7@1236|Gammaproteobacteria,1XHB7@135619|Oceanospirillales 135619|Oceanospirillales E Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) aroE - 1.1.1.25 ko:K00014 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02413 RC00206 ko00000,ko00001,ko00002,ko01000 - - - Shikimate_DH,Shikimate_dh_N k59_354992_1 1411685.U062_02207 2.57e-13 69.7 COG0129@1|root,COG0129@2|Bacteria,1MU3T@1224|Proteobacteria,1RMNA@1236|Gammaproteobacteria,1J4FW@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria EG Belongs to the IlvD Edd family edd GO:0003674,GO:0003824,GO:0004456,GO:0005975,GO:0006082,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016052,GO:0016054,GO:0016829,GO:0016835,GO:0016836,GO:0019520,GO:0019521,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044262,GO:0044275,GO:0044281,GO:0044282,GO:0046176,GO:0046177,GO:0046395,GO:0071704,GO:0072329,GO:1901575 4.2.1.12 ko:K01690 ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200 M00008 R02036 RC00543 ko00000,ko00001,ko00002,ko01000 - - iEcolC_1368.EcolC_1781,iJN746.PP_1010,iPC815.YPO2533,iYL1228.KPN_02366 ILVD_EDD k59_636604_1 497964.CfE428DRAFT_3460 1.81e-20 100.0 COG0457@1|root,COG2304@1|root,COG0457@2|Bacteria,COG2304@2|Bacteria,46SP8@74201|Verrucomicrobia 74201|Verrucomicrobia J von Willebrand factor (vWF) type A domain - - - - - - - - - - - - VWA_2 k59_974912_1 1117647.M5M_17475 2.52e-97 298.0 COG0064@1|root,COG0064@2|Bacteria,1MUKG@1224|Proteobacteria,1RP7U@1236|Gammaproteobacteria,1J4ZC@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) gatB GO:0003674,GO:0003824,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564 6.3.5.6,6.3.5.7 ko:K02434 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - GatB_N,GatB_Yqey k59_863642_1 316407.85675654 1.11e-31 120.0 COG0019@1|root,COG0019@2|Bacteria,1MUA6@1224|Proteobacteria,1RMI2@1236|Gammaproteobacteria,3XNIT@561|Escherichia 1236|Gammaproteobacteria E Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine lysA GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0008836,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016829,GO:0016830,GO:0016831,GO:0019752,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046451,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.1.1.20 ko:K01586 ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R00451 RC00299 ko00000,ko00001,ko00002,ko01000 - - iG2583_1286.G2583_3495 Orn_Arg_deC_N,Orn_DAP_Arg_deC k59_863642_2 316407.85675653 4.24e-76 235.0 COG1609@1|root,COG1609@2|Bacteria,1MU1G@1224|Proteobacteria,1RMSP@1236|Gammaproteobacteria,3XNH3@561|Escherichia 1236|Gammaproteobacteria K Transcriptional regulator GalR galR GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005515,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031326,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1903506,GO:2000112,GO:2001141 - ko:K02529 - - - - ko00000,ko03000 - - - LacI,Peripla_BP_3 k59_298500_1 521010.BbiDN127_0328 8.71e-31 124.0 COG4166@1|root,COG4166@2|Bacteria,2J687@203691|Spirochaetes 203691|Spirochaetes E extracellular solute-binding protein, family 5 oppA-3 - - ko:K02035,ko:K15580 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00239,M00439 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 - - SBP_bac_5 k59_806654_1 883080.HMPREF9697_00800 1.03e-11 68.2 COG0451@1|root,COG0451@2|Bacteria,1PB4Y@1224|Proteobacteria,2TTV7@28211|Alphaproteobacteria,3JWIV@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria M 3-beta hydroxysteroid dehydrogenase/isomerase family - - 5.1.3.2 ko:K01784 ko00052,ko00520,ko01100,map00052,map00520,map01100 M00361,M00362,M00632 R00291,R02984 RC00289 ko00000,ko00001,ko00002,ko01000 - - - Epimerase k59_1427279_1 1223523.H340_24680 5.05e-50 176.0 COG0001@1|root,COG0001@2|Bacteria,2GKJV@201174|Actinobacteria 201174|Actinobacteria H Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family - - 5.4.3.8 ko:K01845 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R02272 RC00677 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 k59_1427279_2 1007105.PT7_0500 6.88e-16 79.0 COG1028@1|root,COG1028@2|Bacteria,1MUFX@1224|Proteobacteria,2VPKC@28216|Betaproteobacteria,3T2XP@506|Alcaligenaceae 28216|Betaproteobacteria IQ Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - - - - - - - - - - - adh_short_C2 k59_1654139_1 485913.Krac_7358 1.27e-59 204.0 COG1472@1|root,COG1472@2|Bacteria,2G84T@200795|Chloroflexi 200795|Chloroflexi G PFAM glycoside hydrolase, family 3 domain protein - - 3.2.1.21 ko:K05349 ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110 - R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040 RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248 ko00000,ko00001,ko01000 - GH3 - Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C k59_974924_1 1082933.MEA186_11431 2.28e-49 173.0 COG0446@1|root,COG0446@2|Bacteria,1NR3M@1224|Proteobacteria,2TS0K@28211|Alphaproteobacteria,43HTS@69277|Phyllobacteriaceae 28211|Alphaproteobacteria S pyridine nucleotide-disulfide oxidoreductase thcD - 1.14.13.111,1.18.1.3 ko:K00529,ko:K16968 ko00071,ko00360,ko00920,ko01120,ko01220,map00071,map00360,map00920,map01120,map01220 M00545 R02000,R06782,R06783,R09513 RC00098,RC02556 br01602,ko00000,ko00001,ko00002,ko01000 - - - Pyr_redox_2,Reductase_C k59_974924_2 1380347.JNII01000005_gene3188 1.42e-93 285.0 COG0667@1|root,COG0667@2|Bacteria,2ICY2@201174|Actinobacteria 201174|Actinobacteria C Aldo/keto reductase family - - - - - - - - - - - - Aldo_ket_red k59_693109_1 1218076.BAYB01000029_gene4755 9.93e-50 172.0 COG1960@1|root,COG1960@2|Bacteria,1MUBH@1224|Proteobacteria,2VHX0@28216|Betaproteobacteria,1K0SX@119060|Burkholderiaceae 28216|Betaproteobacteria C acyl-CoA dehydrogenase - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_580146_1 604331.AUHY01000040_gene92 3.62e-84 264.0 COG0554@1|root,COG0554@2|Bacteria,1WI6Q@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus C Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate glpK GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615 2.7.1.30 ko:K00864 ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626 - R00847 RC00002,RC00017 ko00000,ko00001,ko01000,ko04147 - - - FGGY_C,FGGY_N k59_241131_1 887062.HGR_02578 7.85e-158 454.0 COG1894@1|root,COG1894@2|Bacteria,1MV8F@1224|Proteobacteria,2VJJ1@28216|Betaproteobacteria,4AAFV@80864|Comamonadaceae 28216|Betaproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain nuoF - 1.6.5.3 ko:K00335 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_51K,NADH_4Fe-4S,SLBB k59_241131_2 1454004.AW11_00863 5.68e-17 75.9 COG1905@1|root,COG1905@2|Bacteria,1MWS2@1224|Proteobacteria,2VQD9@28216|Betaproteobacteria,1KPZW@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria C NADH dehydrogenase I subunit E nuoE - 1.6.5.3 ko:K00334 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - 2Fe-2S_thioredx k59_919108_1 1139219.I569_00497 2.51e-16 80.5 COG1051@1|root,COG1051@2|Bacteria,1U7WX@1239|Firmicutes,4HHQT@91061|Bacilli,4B27V@81852|Enterococcaceae 91061|Bacilli F Hydrolase of X-linked nucleoside diphosphate N terminal yjhB - 3.6.1.13 ko:K01515 ko00230,map00230 - R01054 RC00002 ko00000,ko00001,ko01000 - - - NUDIX,Nudix_N k59_749513_1 1123368.AUIS01000032_gene1398 5.94e-111 345.0 COG0398@1|root,COG1502@1|root,COG0398@2|Bacteria,COG1502@2|Bacteria,1MV8I@1224|Proteobacteria,1RSB6@1236|Gammaproteobacteria 1236|Gammaproteobacteria I Pfam SNARE associated Golgi protein - - - - - - - - - - - - PLDc,PLDc_2,SNARE_assoc k59_1033094_1 1500894.JQNN01000001_gene2617 7.84e-35 133.0 COG0303@1|root,COG0746@1|root,COG0303@2|Bacteria,COG0746@2|Bacteria,1MVD5@1224|Proteobacteria,2VH78@28216|Betaproteobacteria,473QZ@75682|Oxalobacteraceae 28216|Betaproteobacteria H Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor moeA2 - 2.10.1.1 ko:K03750 ko00790,ko01100,map00790,map01100 - R09735 RC03462 ko00000,ko00001,ko01000 - - - MoCF_biosynth,MoeA_C,MoeA_N k59_1654153_1 436308.Nmar_1234 1.96e-225 625.0 COG0489@1|root,arCOG01846@1|root,arCOG00585@2157|Archaea,arCOG01846@2157|Archaea,41SF1@651137|Thaumarchaeota 651137|Thaumarchaeota D Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP - - - ko:K03593 - - - - ko00000,ko03029,ko03036 - - - FeS_assembly_P,ParA k59_1427303_1 1082933.MEA186_31406 1.11e-161 462.0 COG0123@1|root,COG0123@2|Bacteria,1MU7P@1224|Proteobacteria,2TRRH@28211|Alphaproteobacteria,43JHB@69277|Phyllobacteriaceae 28211|Alphaproteobacteria BQ including yeast histone deacetylase and acetoin utilization protein - - - - - - - - - - - - Hist_deacetyl k59_758235_1 436308.Nmar_1312 1.36e-100 303.0 COG0334@1|root,arCOG01352@2157|Archaea,41S7T@651137|Thaumarchaeota 651137|Thaumarchaeota E Belongs to the Glu Leu Phe Val dehydrogenases family - - 1.4.1.3 ko:K00261 ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964 M00740 R00243,R00248 RC00006,RC02799 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ELFV_dehydrog,ELFV_dehydrog_N k59_309068_1 436308.Nmar_0011 7.49e-196 561.0 COG0464@1|root,arCOG01308@2157|Archaea,41SX8@651137|Thaumarchaeota 651137|Thaumarchaeota O Cell division protein 48 (CDC48), domain 2 - - - ko:K13525 ko04141,ko05134,map04141,map05134 M00400,M00403 - - ko00000,ko00001,ko00002,ko03019,ko04131,ko04147 3.A.16.1 - - AAA,CDC48_2,CDC48_N k59_703836_1 298653.Franean1_1935 1.66e-146 457.0 COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,2GN09@201174|Actinobacteria,4ERS2@85013|Frankiales 201174|Actinobacteria E Glutamate synthase gltB GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006541,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0015930,GO:0016020,GO:0016053,GO:0016491,GO:0016638,GO:0019676,GO:0019740,GO:0019752,GO:0040007,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.4.1.13,1.4.1.14,1.4.7.1 ko:K00265,ko:K00284 ko00250,ko00630,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00630,map00910,map01100,map01110,map01120,map01130,map01230 - R00021,R00093,R00114,R00248,R10086 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - GATase_2,GXGXG,Glu_syn_central,Glu_synthase k59_26297_1 436308.Nmar_1191 3.74e-67 223.0 COG1331@1|root,arCOG02007@2157|Archaea,41SHZ@651137|Thaumarchaeota 651137|Thaumarchaeota O Protein of unknown function, DUF255 - - - ko:K06888 - - - - ko00000 - - - Thioredox_DsbH k59_1044001_1 526227.Mesil_3485 4.62e-78 244.0 COG3385@1|root,COG3385@2|Bacteria 2|Bacteria L transposase activity - - - - - - - - - - - - DDE_5 k59_1552114_1 203122.Sde_1893 6.83e-110 340.0 COG1049@1|root,COG1049@2|Bacteria,1MVCR@1224|Proteobacteria,1RNMC@1236|Gammaproteobacteria,46445@72275|Alteromonadaceae 1236|Gammaproteobacteria C Belongs to the aconitase IPM isomerase family acnB - 4.2.1.3,4.2.1.99 ko:K01682 ko00020,ko00630,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00173 R01324,R01325,R01900,R04425 RC00497,RC00498,RC00618,RC01153 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase,Aconitase_2_N,Aconitase_B_N k59_1266667_1 641526.ADIWIN_2255 9.64e-48 158.0 COG0262@1|root,COG0262@2|Bacteria,4NTP8@976|Bacteroidetes,1I3X6@117743|Flavobacteriia 976|Bacteroidetes H 2TM domain - - - - - - - - - - - - 2TM k59_1266667_2 1380600.AUYN01000009_gene1147 6.67e-34 124.0 COG0262@1|root,COG0262@2|Bacteria,4NQ2Y@976|Bacteroidetes,1I272@117743|Flavobacteriia 976|Bacteroidetes H Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis folA - 1.5.1.3 ko:K00287 ko00670,ko00790,ko01100,ko01523,map00670,map00790,map01100,map01523 M00126,M00840 R00936,R00937,R00939,R00940,R02235,R02236,R11765 RC00109,RC00110,RC00158 ko00000,ko00001,ko00002,ko01000 - - - 2TM,DHFR_1 k59_645475_2 1173022.Cri9333_0100 1.33e-32 123.0 COG3021@1|root,COG3021@2|Bacteria,1G1V5@1117|Cyanobacteria,1HAVR@1150|Oscillatoriales 1117|Cyanobacteria S Endonuclease Exonuclease phosphatase - - - - - - - - - - - - Exo_endo_phos k59_1382325_1 1192034.CAP_4132 1.6e-71 241.0 COG1331@1|root,COG1331@2|Bacteria,1MUUT@1224|Proteobacteria,42MP3@68525|delta/epsilon subdivisions,2WJ7Y@28221|Deltaproteobacteria,2YX41@29|Myxococcales 28221|Deltaproteobacteria O Protein of unknown function, DUF255 yyaL - - ko:K06888 - - - - ko00000 - - - GlcNAc_2-epim,Thioredox_DsbH k59_139024_1 987059.RBXJA2T_14421 1.12e-57 181.0 COG0316@1|root,COG0316@2|Bacteria,1RHCW@1224|Proteobacteria,2VR2M@28216|Betaproteobacteria,1KKSP@119065|unclassified Burkholderiales 28216|Betaproteobacteria C Required for insertion of 4Fe-4S clusters erpA - - ko:K15724 - - - - ko00000 - - - Fe-S_biosyn k59_1154820_1 1121887.AUDK01000024_gene1090 3.23e-77 251.0 COG1082@1|root,COG1082@2|Bacteria,4NEWC@976|Bacteroidetes,1HY05@117743|Flavobacteriia,2NSRK@237|Flavobacterium 976|Bacteroidetes G Alpha-glucosidase - - 3.2.1.20,3.2.1.3 ko:K01187,ko:K21574 ko00052,ko00500,ko01100,map00052,map00500,map01100 - R00028,R00801,R00802,R01790,R01791,R06087,R06088 RC00028,RC00049,RC00077 ko00000,ko00001,ko01000 - GH31,GH97 - GH97_C,GH97_N,Glyco_hydro_97 k59_1154820_2 1121912.AUHD01000001_gene2895 4.46e-64 215.0 COG1472@1|root,COG1472@2|Bacteria,4NE90@976|Bacteroidetes,1HX27@117743|Flavobacteriia 976|Bacteroidetes G Belongs to the glycosyl hydrolase 3 family bglX - 3.2.1.21 ko:K05349 ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110 - R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040 RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248 ko00000,ko00001,ko01000 - GH3 - Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C k59_703848_1 768671.ThimaDRAFT_0622 6.16e-99 308.0 COG0584@1|root,COG0584@2|Bacteria,1MU8H@1224|Proteobacteria,1RQWX@1236|Gammaproteobacteria,1WZGU@135613|Chromatiales 135613|Chromatiales C PFAM Glycerophosphoryl diester phosphodiesterase - - 3.1.4.46 ko:K01126 ko00564,map00564 - R01030,R01470 RC00017,RC00425 ko00000,ko00001,ko01000 - - - GDPD k59_1382331_2 1408444.JHYC01000008_gene1320 5.2e-29 113.0 COG3608@1|root,COG3608@2|Bacteria,1MUAA@1224|Proteobacteria,1RNQQ@1236|Gammaproteobacteria,1JC5A@118969|Legionellales 118969|Legionellales S Succinylglutamate desuccinylase / Aspartoacylase family - - - ko:K06987 - - - - ko00000 - - - AstE_AspA k59_420345_1 1112204.GPOL_c21930 3.01e-18 87.4 COG0558@1|root,COG0558@2|Bacteria,2GYKW@201174|Actinobacteria,4GAFV@85026|Gordoniaceae 201174|Actinobacteria I CDP-alcohol phosphatidyltransferase pgsA1 GO:0003674,GO:0003824,GO:0003881,GO:0003882,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0006629,GO:0006644,GO:0006650,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016740,GO:0016772,GO:0016780,GO:0017169,GO:0019637,GO:0030312,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044464,GO:0045017,GO:0046474,GO:0046486,GO:0071704,GO:0071944,GO:0090407,GO:1901576 2.7.8.11,2.7.8.5 ko:K00995,ko:K00999 ko00562,ko00564,ko01100,ko04070,map00562,map00564,map01100,map04070 - R01801,R01802 RC00002,RC00017,RC00078,RC02795 ko00000,ko00001,ko01000 - - - CDP-OH_P_transf k59_1495672_1 247634.GPB2148_3272 1.37e-52 184.0 COG0639@1|root,COG0639@2|Bacteria,1QEIM@1224|Proteobacteria,1RZDP@1236|Gammaproteobacteria 1236|Gammaproteobacteria T COG0639 Diadenosine tetraphosphatase and related serine threonine protein phosphatases - - - - - - - - - - - - Metallophos k59_1212305_1 1415778.JQMM01000001_gene1174 2.62e-33 119.0 COG0071@1|root,COG0071@2|Bacteria,1N7C7@1224|Proteobacteria,1S607@1236|Gammaproteobacteria,1J70E@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O Belongs to the small heat shock protein (HSP20) family - - - ko:K13993 ko04141,map04141 - - - ko00000,ko00001,ko03110 - - - HSP20 k59_475842_1 247633.GP2143_16781 6.64e-128 370.0 COG1082@1|root,COG1082@2|Bacteria,1MVSJ@1224|Proteobacteria,1RRKK@1236|Gammaproteobacteria,1J5MG@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L AP endonuclease family 2 C terminus - - - - - - - - - - - - AP_endonuc_2,AP_endonuc_2_N k59_814931_1 1415779.JOMH01000001_gene2583 2.39e-109 330.0 COG0129@1|root,COG0129@2|Bacteria,1MUTQ@1224|Proteobacteria,1RMP2@1236|Gammaproteobacteria,1X4TP@135614|Xanthomonadales 135614|Xanthomonadales E Belongs to the IlvD Edd family - - - - - - - - - - - - ILVD_EDD k59_1552136_1 211165.AJLN01000068_gene4599 3.23e-23 100.0 COG0520@1|root,COG0520@2|Bacteria,1G4XH@1117|Cyanobacteria,1JIED@1189|Stigonemataceae 1117|Cyanobacteria E Cys/Met metabolism PLP-dependent enzyme - - - - - - - - - - - - Aminotran_5 k59_1552136_2 1173025.GEI7407_2253 3.17e-23 100.0 COG3338@1|root,COG3338@2|Bacteria,1G5J4@1117|Cyanobacteria,1HBC2@1150|Oscillatoriales 1117|Cyanobacteria P carbonic anhydrase ecaA - 4.2.1.1 ko:K01674 ko00910,map00910 - R00132,R10092 RC02807 ko00000,ko00001,ko01000 - - - Carb_anhydrase k59_420350_1 1502850.FG91_01897 2.22e-61 199.0 COG3828@1|root,COG3828@2|Bacteria,1RF65@1224|Proteobacteria,2UA54@28211|Alphaproteobacteria,2K450@204457|Sphingomonadales 204457|Sphingomonadales S Trehalose utilisation - - - ko:K09992 - - - - ko00000 - - - ThuA k59_1495685_1 315456.RF_0730 7.12e-49 162.0 COG0242@1|root,COG0242@2|Bacteria,1RM12@1224|Proteobacteria,2UAFH@28211|Alphaproteobacteria,47G82@766|Rickettsiales 766|Rickettsiales J Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions def2 - 3.5.1.88 ko:K01462 - - - - ko00000,ko01000 - - - Pep_deformylase k59_531441_1 1122622.ATWJ01000007_gene1664 4.69e-15 75.9 COG2801@1|root,COG2801@2|Bacteria,2GKDY@201174|Actinobacteria,4FEXK@85021|Intrasporangiaceae 201174|Actinobacteria L COG2801 Transposase and inactivated derivatives - - - ko:K07497 - - - - ko00000 - - - HTH_21,rve,rve_2,rve_3 k59_531441_2 316273.XCV2263 1.22e-20 85.9 COG2963@1|root,COG2963@2|Bacteria,1N28U@1224|Proteobacteria,1S9BK@1236|Gammaproteobacteria,1XAPX@135614|Xanthomonadales 135614|Xanthomonadales L Transposase - - - ko:K07483 - - - - ko00000 - - - HTH_Tnp_1 k59_1436197_1 330779.Saci_0416 6.75e-12 68.6 COG0517@1|root,arCOG00606@2157|Archaea,2XQQK@28889|Crenarchaeota 28889|Crenarchaeota S PFAM CBS domain containing protein - - - - - - - - - - - - CBS k59_1212321_1 1120953.AUBH01000008_gene250 1.14e-34 136.0 COG0771@1|root,COG0771@2|Bacteria,1MVYD@1224|Proteobacteria,1RP25@1236|Gammaproteobacteria,465HJ@72275|Alteromonadaceae 1236|Gammaproteobacteria M Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) murD GO:0000270,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008764,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0030203,GO:0034645,GO:0042546,GO:0042802,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 6.3.2.9 ko:K01925 ko00471,ko00550,ko01100,map00471,map00550,map01100 - R02783 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - iAPECO1_1312.APECO1_1898,iECNA114_1301.ECNA114_0081,iECOK1_1307.ECOK1_0089,iECP_1309.ECP_0090,iECS88_1305.ECS88_0091,iECSF_1327.ECSF_0098,iLF82_1304.LF82_1418,iNRG857_1313.NRG857_00450,iUMN146_1321.UM146_23225,iUTI89_1310.UTI89_C0097 Mur_ligase_C,Mur_ligase_M k59_1382357_1 745310.G432_12965 4.48e-94 280.0 COG2080@1|root,COG2080@2|Bacteria,1MY3F@1224|Proteobacteria,2TRGH@28211|Alphaproteobacteria,2K11H@204457|Sphingomonadales 204457|Sphingomonadales C aerobic-type carbon monoxide dehydrogenase, small subunit CoxS - - - ko:K13483 ko00230,ko01100,ko01120,map00230,map01100,map01120 M00546 R01768,R02103 RC00143 ko00000,ko00001,ko00002 - - - Fer2,Fer2_2 k59_1552158_1 1437609.BCAL_0193 0.000173 50.4 COG3941@1|root,COG5412@1|root,COG3941@2|Bacteria,COG5412@2|Bacteria,2H75F@201174|Actinobacteria,4CZ1P@85004|Bifidobacteriales 201174|Actinobacteria NT phage tail tape measure protein - - - - - - - - - - - - - k59_1097830_1 1443665.JACA01000005_gene464 5.1e-10 67.0 COG1629@1|root,COG4771@2|Bacteria,4NFJJ@976|Bacteroidetes,1HXEC@117743|Flavobacteriia,2YGYI@290174|Aquimarina 976|Bacteroidetes P TonB dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - CarbopepD_reg_2,Plug,TonB_dep_Rec k59_645501_1 649831.L083_6556 3.08e-244 689.0 2DB71@1|root,2Z7JE@2|Bacteria,2I2SN@201174|Actinobacteria,4DMCH@85008|Micromonosporales 201174|Actinobacteria Q Animal haem peroxidase - - - - - - - - - - - - An_peroxidase k59_645501_2 1463856.JOHY01000014_gene3422 3.52e-34 130.0 COG1073@1|root,COG1073@2|Bacteria,2I2YU@201174|Actinobacteria 201174|Actinobacteria S alpha beta - - - - - - - - - - - - - k59_309125_2 198628.Dda3937_02816 4.38e-90 273.0 COG0745@1|root,COG0745@2|Bacteria,1MVCB@1224|Proteobacteria,1RMD0@1236|Gammaproteobacteria,2JCPZ@204037|Dickeya 1236|Gammaproteobacteria T Two component transcriptional regulator, winged helix family baeR GO:0000976,GO:0000984,GO:0000986,GO:0000987,GO:0001017,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031334,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0042802,GO:0043170,GO:0043254,GO:0043565,GO:0044087,GO:0044089,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0045893,GO:0045935,GO:0046483,GO:0048518,GO:0048522,GO:0048583,GO:0050789,GO:0050794,GO:0051128,GO:0051130,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2000142,GO:2000144,GO:2001023,GO:2001141 - ko:K07664,ko:K18144 ko01501,ko02020,map01501,map02020 M00450,M00645,M00646,M00648,M00649,M00655 - - ko00000,ko00001,ko00002,ko01504,ko02022 - - - Response_reg,Trans_reg_C k59_309125_3 543728.Vapar_4258 4.31e-29 116.0 COG0642@1|root,COG3850@1|root,COG2205@2|Bacteria,COG3850@2|Bacteria,1N17V@1224|Proteobacteria,2VK7C@28216|Betaproteobacteria,4ABIY@80864|Comamonadaceae 28216|Betaproteobacteria T histidine kinase HAMP region domain protein baeS - 2.7.13.3 ko:K07642 ko02020,map02020 M00450,M00645,M00646,M00648 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,HisKA k59_1608182_1 292415.Tbd_0541 4.47e-47 169.0 COG0642@1|root,COG0642@2|Bacteria,1R49A@1224|Proteobacteria,2VKU5@28216|Betaproteobacteria 28216|Betaproteobacteria T Histidine kinase-like ATPases - - - - - - - - - - - - HATPase_c k59_365939_1 96561.Dole_1895 2.87e-41 151.0 COG1028@1|root,COG3347@1|root,COG1028@2|Bacteria,COG3347@2|Bacteria,1MWSB@1224|Proteobacteria,42MXK@68525|delta/epsilon subdivisions,2WKEJ@28221|Deltaproteobacteria,2MI70@213118|Desulfobacterales 28221|Deltaproteobacteria IQ PFAM class II aldolase adducin family protein - - - - - - - - - - - - Aldolase_II,adh_short,adh_short_C2 k59_365939_2 1123354.AUDR01000015_gene405 6.37e-48 166.0 COG0700@1|root,COG2715@1|root,COG0700@2|Bacteria,COG2715@2|Bacteria,1MVZ0@1224|Proteobacteria,2VKEY@28216|Betaproteobacteria,1KRGF@119069|Hydrogenophilales 119069|Hydrogenophilales S Nucleoside recognition - - - - - - - - - - - - Gate k59_26359_1 1231392.OCGS_2830 7.93e-138 400.0 COG0183@1|root,COG0183@2|Bacteria,1MU8C@1224|Proteobacteria,2TS6P@28211|Alphaproteobacteria 28211|Alphaproteobacteria I Belongs to the thiolase family - - 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N k59_139084_1 316407.85676003 1.65e-113 328.0 COG3155@1|root,COG3155@2|Bacteria,1MW2K@1224|Proteobacteria,1RMDJ@1236|Gammaproteobacteria,3XMZK@561|Escherichia 1236|Gammaproteobacteria Q Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate elbB GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009893,GO:0009987,GO:0019216,GO:0019222,GO:0019747,GO:0031323,GO:0031325,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0045828,GO:0045834,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0065007,GO:0071704,GO:0080090,GO:1901576 - - - - - - - - - - DJ-1_PfpI k59_758282_1 158500.BV97_02083 3.83e-71 220.0 COG3279@1|root,COG3279@2|Bacteria,1MUE8@1224|Proteobacteria,2U0M2@28211|Alphaproteobacteria,2K2B0@204457|Sphingomonadales 204457|Sphingomonadales KT Response regulator of the LytR AlgR family - - - ko:K08083 ko02020,map02020 M00493 - - ko00000,ko00001,ko00002,ko02022 - - - LytTR,Response_reg k59_758283_1 1122201.AUAZ01000012_gene1335 1.73e-68 226.0 COG0768@1|root,COG0768@2|Bacteria,1MV8C@1224|Proteobacteria,1RN9H@1236|Gammaproteobacteria,464KX@72275|Alteromonadaceae 1236|Gammaproteobacteria M Catalyzes cross-linking of the peptidoglycan cell wall mrdA GO:0000270,GO:0003674,GO:0003824,GO:0004180,GO:0004185,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006022,GO:0006023,GO:0006024,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0008238,GO:0008360,GO:0008658,GO:0009002,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016021,GO:0016043,GO:0016787,GO:0017171,GO:0019538,GO:0022603,GO:0022604,GO:0030203,GO:0031224,GO:0031226,GO:0031406,GO:0033218,GO:0033293,GO:0034645,GO:0036094,GO:0042221,GO:0042493,GO:0042546,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044425,GO:0044459,GO:0044464,GO:0045229,GO:0046677,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051128,GO:0065007,GO:0065008,GO:0070008,GO:0070011,GO:0070589,GO:0071554,GO:0071555,GO:0071704,GO:0071840,GO:0071944,GO:0071972,GO:0097159,GO:0140096,GO:1901135,GO:1901137,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901681 3.4.16.4 ko:K05515 ko00550,ko01501,map00550,map01501 - - - ko00000,ko00001,ko01000,ko01011 - - iEcE24377_1341.EcE24377A_0661,iPC815.YPO2604 PBP_dimer,Transpeptidase k59_590654_1 472759.Nhal_1154 5.49e-100 317.0 COG1277@1|root,COG3225@1|root,COG1277@2|Bacteria,COG3225@2|Bacteria,1NZZ9@1224|Proteobacteria,1RP6C@1236|Gammaproteobacteria,1WX0W@135613|Chromatiales 135613|Chromatiales N transport system - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_2,ABC_transp_aux k59_83548_1 1081640.AGFU01000037_gene3025 2.61e-26 116.0 COG2931@1|root,COG2931@2|Bacteria,1RD10@1224|Proteobacteria,2U9TE@28211|Alphaproteobacteria,2K1W4@204457|Sphingomonadales 204457|Sphingomonadales Q calcium- and calmodulin-responsive adenylate cyclase activity - - - - - - - - - - - - - k59_1266751_1 1209072.ALBT01000029_gene2208 5.62e-36 130.0 COG1121@1|root,COG1121@2|Bacteria,1MUDW@1224|Proteobacteria,1RPJT@1236|Gammaproteobacteria,1FGPN@10|Cellvibrio 1236|Gammaproteobacteria P Part of the ABC transporter complex ZnuABC involved in zinc import. Responsible for energy coupling to the transport system znuC GO:0000041,GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005385,GO:0005488,GO:0005524,GO:0006810,GO:0006811,GO:0006812,GO:0006829,GO:0008144,GO:0008150,GO:0008324,GO:0015075,GO:0015318,GO:0015399,GO:0015405,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022890,GO:0030001,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0043167,GO:0043168,GO:0043492,GO:0046873,GO:0046915,GO:0051179,GO:0051234,GO:0055085,GO:0070838,GO:0071577,GO:0072509,GO:0072511,GO:0097159,GO:0097367,GO:0098655,GO:0098660,GO:0098662,GO:1901265,GO:1901363 - ko:K09817 ko02010,map02010 M00242 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.15.3,3.A.1.15.5 - iSFV_1184.SFV_1859,iSF_1195.SF1867,iSFxv_1172.SFxv_2092,iS_1188.S1934 ABC_tran k59_1266751_2 391937.NA2_04556 3.63e-32 120.0 COG1108@1|root,COG1108@2|Bacteria,1MVC2@1224|Proteobacteria,2TS2V@28211|Alphaproteobacteria,43GZN@69277|Phyllobacteriaceae 28211|Alphaproteobacteria P ABC 3 transport family znuB GO:0000006,GO:0000041,GO:0003674,GO:0005215,GO:0005385,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006829,GO:0008150,GO:0008324,GO:0010035,GO:0010038,GO:0010043,GO:0015075,GO:0015318,GO:0016020,GO:0022857,GO:0022890,GO:0030001,GO:0034220,GO:0042221,GO:0044464,GO:0046873,GO:0046915,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0070838,GO:0071577,GO:0071944,GO:0072509,GO:0072511,GO:0098655,GO:0098660,GO:0098662 - ko:K09816 ko02010,map02010 M00242 - - ko00000,ko00001,ko00002,ko02000 3.A.1.15.3,3.A.1.15.5 - - ABC-3 k59_83554_1 1044.EH31_13790 7.46e-75 249.0 COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,2TRWM@28211|Alphaproteobacteria,2K0B8@204457|Sphingomonadales 204457|Sphingomonadales P Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K15726 - - - - ko00000,ko02000 2.A.6.1.2 - - ACR_tran k59_758295_1 635013.TherJR_0733 1.85e-05 49.7 COG0682@1|root,COG0682@2|Bacteria,1TPAK@1239|Firmicutes,24APG@186801|Clostridia,261Q5@186807|Peptococcaceae 186801|Clostridia M Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins lgt - - ko:K13292 - - - - ko00000,ko01000 - - - LGT k59_26401_1 1276920.ADIAG_02194 2.17e-27 115.0 COG1252@1|root,COG1252@2|Bacteria,2GJFE@201174|Actinobacteria,1W7TQ@1268|Micrococcaceae 201174|Actinobacteria C Pyridine nucleotide-disulphide oxidoreductase - - 1.6.99.3 ko:K03885 ko00190,map00190 - - - ko00000,ko00001,ko01000 - - - Pyr_redox_2 k59_814975_1 62928.azo3572 1.57e-72 236.0 COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,2VHAN@28216|Betaproteobacteria,2KUTR@206389|Rhodocyclales 206389|Rhodocyclales V Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation msbA - - ko:K11085 ko02010,map02010 - - - ko00000,ko00001,ko01000,ko02000 3.A.1.106 - - ABC_membrane,ABC_tran k59_1608222_2 1229909.NSED_01145 1.05e-39 133.0 COG2835@1|root,arCOG04124@2157|Archaea,41STB@651137|Thaumarchaeota 651137|Thaumarchaeota S Trm112p-like protein - - - - - - - - - - - - Trm112p k59_1608222_3 1229909.NSED_01135 1.77e-20 84.0 arCOG11288@1|root,arCOG11288@2157|Archaea,41T86@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1608222_4 436308.Nmar_0244 4.26e-41 145.0 COG0472@1|root,arCOG03199@2157|Archaea,41S8B@651137|Thaumarchaeota 651137|Thaumarchaeota M glycosyl transferase family - - 2.7.8.15 ko:K01001 ko00510,ko01100,map00510,map01100 M00055 R05969 RC00002 ko00000,ko00001,ko00002,ko01000,ko01003 - - - Glycos_transf_4 k59_1154898_1 547144.HydHO_1269 2.72e-31 120.0 COG1023@1|root,COG1023@2|Bacteria 2|Bacteria G D-gluconate metabolic process gnd - 1.1.1.343,1.1.1.44 ko:K00033 ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00480,map01100,map01110,map01120,map01130,map01200 M00004,M00006 R01528,R10221 RC00001,RC00539 ko00000,ko00001,ko00002,ko01000 - - - 6PGD,NAD_binding_2 k59_874343_1 264201.pc0660 9.45e-15 79.0 COG1561@1|root,COG1561@2|Bacteria,2JG0Y@204428|Chlamydiae 204428|Chlamydiae S Domain of unknown function (DUF1732) - - - - - - - - - - - - DUF1732,YicC_N k59_1552239_2 322710.Avin_42910 1.07e-34 122.0 COG1534@1|root,COG1534@2|Bacteria,1N8K5@1224|Proteobacteria,1SDIM@1236|Gammaproteobacteria 1236|Gammaproteobacteria J RNA-binding protein containing KH domain possibly ribosomal protein yhbY GO:0000027,GO:0000028,GO:0000966,GO:0000967,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016072,GO:0022607,GO:0022613,GO:0022618,GO:0034470,GO:0034471,GO:0034622,GO:0034641,GO:0034660,GO:0042254,GO:0042255,GO:0042273,GO:0042274,GO:0043021,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:1901360,GO:1990275 - ko:K07574 - - - - ko00000,ko03009 - - - CRS1_YhbY k59_1552239_3 1122197.ATWI01000010_gene1068 2.92e-31 116.0 COG0293@1|root,COG0293@2|Bacteria,1MW1C@1224|Proteobacteria,1RN5M@1236|Gammaproteobacteria,464RW@72275|Alteromonadaceae 1236|Gammaproteobacteria J Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit ftsJ GO:0000027,GO:0000154,GO:0000451,GO:0000453,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008173,GO:0008649,GO:0008650,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016072,GO:0016436,GO:0016740,GO:0016741,GO:0022607,GO:0022613,GO:0022618,GO:0031167,GO:0032259,GO:0034470,GO:0034622,GO:0034641,GO:0034660,GO:0042254,GO:0042255,GO:0042273,GO:0043170,GO:0043412,GO:0043414,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.166 ko:K02427 - - - - ko00000,ko01000,ko03009 - - - FtsJ k59_814986_1 1054213.HMPREF9946_03416 6.49e-08 57.4 COG0500@1|root,COG0640@1|root,COG0640@2|Bacteria,COG2226@2|Bacteria,1NFSV@1224|Proteobacteria,2TSMV@28211|Alphaproteobacteria,2JPME@204441|Rhodospirillales 204441|Rhodospirillales KQ helix_turn_helix, Arsenical Resistance Operon Repressor - - - - - - - - - - - - HTH_20,HTH_5,Methyltransf_11 k59_1324536_1 1229909.NSED_06860 2.9e-109 335.0 COG0464@1|root,arCOG01308@2157|Archaea,41S7X@651137|Thaumarchaeota 651137|Thaumarchaeota O Cell division protein 48 (CDC48) domain 2 - - - ko:K13525 ko04141,ko05134,map04141,map05134 M00400,M00403 - - ko00000,ko00001,ko00002,ko03019,ko04131,ko04147 3.A.16.1 - - AAA,CDC48_2,CDC48_N k59_1098679_1 95619.PM1_0215755 1.38e-114 336.0 COG1126@1|root,COG1126@2|Bacteria,1MU9Q@1224|Proteobacteria,1RMX1@1236|Gammaproteobacteria 1236|Gammaproteobacteria E (ABC) transporter yhdZ GO:0000166,GO:0003674,GO:0005488,GO:0005524,GO:0008144,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0097159,GO:0097367,GO:1901265,GO:1901363 3.6.3.21 ko:K02028,ko:K02029,ko:K09972 ko02010,map02010 M00232,M00236 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.3,3.A.1.3.17,3.A.1.3.18,3.A.1.3.7,3.A.1.3.8 - iJN746.PP_1300 ABC_tran k59_367102_2 1440774.Y900_016185 7.87e-11 65.5 COG2234@1|root,COG2234@2|Bacteria,2HEN8@201174|Actinobacteria,235II@1762|Mycobacteriaceae 201174|Actinobacteria S Peptidase, M28 lpqL GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - - - - - - - - - - PA,Peptidase_M28 k59_1664300_2 2002.JOEQ01000003_gene2497 4.8e-08 58.9 COG1522@1|root,COG1522@2|Bacteria,2GN6I@201174|Actinobacteria,4EPPE@85012|Streptosporangiales 201174|Actinobacteria K helix_turn_helix ASNC type - - - ko:K03719 - - - - ko00000,ko03000,ko03036 - - - AsnC_trans_reg,HTH_24,HTH_AsnC-type k59_1609276_1 1957.JODX01000021_gene2976 9.56e-10 57.8 COG2041@1|root,COG2041@2|Bacteria,2GMG2@201174|Actinobacteria 201174|Actinobacteria M Oxidoreductase molybdopterin binding - - - - - - - - - - - - Oxidored_molyb k59_1609276_2 926569.ANT_25850 5.22e-49 169.0 COG0265@1|root,COG0265@2|Bacteria,2G6KG@200795|Chloroflexi 200795|Chloroflexi O PFAM peptidase S1 and S6, chymotrypsin Hap - - 3.4.21.107 ko:K04771 ko01503,ko02020,map01503,map02020 M00728 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 - - - PDZ_2,Trypsin_2 k59_875410_1 323848.Nmul_A2562 1.08e-106 317.0 COG0134@1|root,COG0134@2|Bacteria,1MW5K@1224|Proteobacteria,2VIN7@28216|Betaproteobacteria,37291@32003|Nitrosomonadales 28216|Betaproteobacteria E Belongs to the TrpC family trpC GO:0003674,GO:0003824,GO:0004425,GO:0016829,GO:0016830,GO:0016831 4.1.1.48 ko:K01609 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R03508 RC00944 ko00000,ko00001,ko00002,ko01000 - - - IGPS k59_310214_1 1247726.MIM_c29550 4.19e-64 204.0 COG0540@1|root,COG0540@2|Bacteria,1MWAB@1224|Proteobacteria,2VHG9@28216|Betaproteobacteria,3T2G4@506|Alcaligenaceae 28216|Betaproteobacteria F Catalyzes the transfer of the carbamoyl moiety from carbamoyl phosphate to L- aspartate in pyrimidine biosynthesis pyrB - 2.1.3.2 ko:K00609 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R01397 RC00064,RC02850 ko00000,ko00001,ko00002,ko01000 - - - OTCace,OTCace_N k59_476699_1 331869.BAL199_03484 7.27e-55 179.0 COG1028@1|root,COG1028@2|Bacteria,1MW9A@1224|Proteobacteria,2TRFW@28211|Alphaproteobacteria 28211|Alphaproteobacteria IQ Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - - - - - - - - - - - adh_short_C2 k59_984485_1 1049564.TevJSym_at00200 1.49e-72 233.0 COG0438@1|root,COG0438@2|Bacteria,1MU9C@1224|Proteobacteria,1RS5D@1236|Gammaproteobacteria,1J70I@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Glycosyltransferase Family 4 - - - - - - - - - - - - Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1 k59_1383465_1 1121875.KB907546_gene2238 7.21e-59 194.0 COG1409@1|root,COG1409@2|Bacteria,4NFAP@976|Bacteroidetes,1I2DE@117743|Flavobacteriia 976|Bacteroidetes S Calcineurin-like phosphoesterase - - - - - - - - - - - - Metallophos,PA14 k59_1167185_1 158500.BV97_00026 1.76e-49 173.0 2CCEV@1|root,2Z7ZC@2|Bacteria,1PQAK@1224|Proteobacteria,2TUR6@28211|Alphaproteobacteria,2K1PM@204457|Sphingomonadales 204457|Sphingomonadales S Alginate export - - - - - - - - - - - - Alginate_exp k59_430067_1 279238.Saro_3164 1.59e-69 228.0 COG2303@1|root,COG2303@2|Bacteria,1MU3F@1224|Proteobacteria,2TT3C@28211|Alphaproteobacteria,2K0QC@204457|Sphingomonadales 204457|Sphingomonadales E Oxidoreductase - - 1.1.5.9 ko:K19813 ko00030,ko01100,ko01110,ko01130,map00030,map01100,map01110,map01130 - R00305 RC00066 ko00000,ko00001,ko01000 - - - FAD_binding_2,GMC_oxred_C,GMC_oxred_N,NAD_binding_8 k59_767997_1 436308.Nmar_0481 1.34e-78 242.0 COG0573@1|root,arCOG00167@2157|Archaea,41SYE@651137|Thaumarchaeota 651137|Thaumarchaeota P probably responsible for the translocation of the substrate across the membrane - - - ko:K02037 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - BPD_transp_1 k59_540679_1 1121937.AUHJ01000006_gene2459 2.41e-48 165.0 COG2141@1|root,COG2141@2|Bacteria,1MWI8@1224|Proteobacteria,1S10Y@1236|Gammaproteobacteria,468VQ@72275|Alteromonadaceae 1236|Gammaproteobacteria C Luciferase-like monooxygenase - - - - - - - - - - - - Bac_luciferase k59_1107858_1 1968.JOEV01000032_gene8127 1.75e-18 85.9 COG1802@1|root,COG1802@2|Bacteria,2I8SM@201174|Actinobacteria 201174|Actinobacteria K gntR family - - - - - - - - - - - - FCD,GntR k59_1107858_2 1223410.KN050846_gene200 8.43e-05 47.0 COG4799@1|root,COG4799@2|Bacteria,4NEMJ@976|Bacteroidetes,1HY0V@117743|Flavobacteriia 976|Bacteroidetes I Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) accD5 - - - - - - - - - - - Carboxyl_trans k59_604007_1 522306.CAP2UW1_2897 5.43e-17 76.3 COG5416@1|root,COG5416@2|Bacteria 2|Bacteria FG Lipopolysaccharide assembly protein A domain lapA - - ko:K08992 - - - - ko00000 - - - LapA_dom k59_604007_2 640081.Dsui_1946 1.12e-50 171.0 COG2956@1|root,COG2956@2|Bacteria,1MVDP@1224|Proteobacteria,2VH49@28216|Betaproteobacteria,2KU7Z@206389|Rhodocyclales 206389|Rhodocyclales G Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane lapB - - ko:K19804 - - - - ko00000 - - - TPR_16 k59_887159_1 485913.Krac_8276 2.84e-36 136.0 COG0657@1|root,COG0657@2|Bacteria 2|Bacteria I acetylesterase activity - - - ko:K01066 - - - - ko00000,ko01000 - - - Abhydrolase_3 k59_887159_2 392499.Swit_3313 4.12e-85 259.0 COG4221@1|root,COG4221@2|Bacteria,1MVYG@1224|Proteobacteria,2VEVF@28211|Alphaproteobacteria,2K1H0@204457|Sphingomonadales 204457|Sphingomonadales S Belongs to the short-chain dehydrogenases reductases (SDR) family - - - - - - - - - - - - adh_short k59_1731319_1 1122201.AUAZ01000008_gene360 1e-71 231.0 COG1249@1|root,COG1249@2|Bacteria,1MU2Z@1224|Proteobacteria,1RMC0@1236|Gammaproteobacteria,46406@72275|Alteromonadaceae 1236|Gammaproteobacteria C Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family gor GO:0000166,GO:0003674,GO:0003824,GO:0004362,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0015036,GO:0015037,GO:0015038,GO:0016209,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0036094,GO:0042221,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0048037,GO:0050660,GO:0050662,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0071949,GO:0097159,GO:0097237,GO:0098754,GO:0098869,GO:1901265,GO:1901363,GO:1990748 1.8.1.7 ko:K00383 ko00480,ko04918,map00480,map04918 - R00094,R00115 RC00011 ko00000,ko00001,ko01000 - - iZ_1308.Z4900 Pyr_redox_2,Pyr_redox_dim k59_655782_1 316407.85676772 3.91e-250 696.0 COG1283@1|root,COG1283@2|Bacteria,1MUDE@1224|Proteobacteria,1RNMM@1236|Gammaproteobacteria,3XNUB@561|Escherichia 1236|Gammaproteobacteria P sodium-dependent phosphate transmembrane transporter activity yjbB GO:0003674,GO:0005215,GO:0005315,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006817,GO:0006820,GO:0008150,GO:0015291,GO:0015318,GO:0015698,GO:0016020,GO:0022804,GO:0022857,GO:0034220,GO:0035435,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098656,GO:0098660,GO:0098661 - ko:K03324 - - - - ko00000,ko02000 2.A.58.2 - - Na_Pi_cotrans,PhoU k59_1731324_1 395493.BegalDRAFT_0383 2.5e-112 332.0 COG0714@1|root,COG0714@2|Bacteria,1MUFN@1224|Proteobacteria,1RP45@1236|Gammaproteobacteria,45ZZF@72273|Thiotrichales 72273|Thiotrichales S PFAM ATPase family associated with various cellular activities (AAA) - - - ko:K03924 - - - - ko00000,ko01000 - - - AAA_3 k59_1055457_1 1336237.JAEE01000008_gene89 6.41e-79 259.0 COG0532@1|root,COG0532@2|Bacteria,1MV26@1224|Proteobacteria,1RM9X@1236|Gammaproteobacteria 1236|Gammaproteobacteria J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex infB GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003676,GO:0003723,GO:0003743,GO:0003824,GO:0003924,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006413,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019538,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034641,GO:0034645,GO:0036094,GO:0043021,GO:0043024,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0097159,GO:0097216,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - ko:K02519 - - - - ko00000,ko03012,ko03029 - - - GTP_EFTU,GTP_EFTU_D2,IF-2,IF2_N,IF2_assoc k59_1565968_1 1122137.AQXF01000002_gene428 4.37e-92 280.0 COG1171@1|root,COG1171@2|Bacteria,1MVWJ@1224|Proteobacteria,2TQN9@28211|Alphaproteobacteria 28211|Alphaproteobacteria E threonine dehydratase ilvA - 4.3.1.19 ko:K01754 ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230 M00570 R00220,R00996 RC00418,RC02600 ko00000,ko00001,ko00002,ko01000 - - - ACT,ACT_4,PALP k59_1673213_1 1266909.AUAG01000010_gene2659 9.25e-139 421.0 COG0550@1|root,COG0550@2|Bacteria,1MUFZ@1224|Proteobacteria,1RNZ2@1236|Gammaproteobacteria,1WWWP@135613|Chromatiales 135613|Chromatiales L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone topA - 5.99.1.2 ko:K03168 - - - - ko00000,ko01000,ko03032,ko03400 - - - Topo_Zn_Ribbon,Topoisom_bac,Toprim,Toprim_C_rpt,zf-C4_Topoisom k59_1107879_1 1366050.N234_16570 6.61e-87 270.0 COG0277@1|root,COG0277@2|Bacteria,1MV1Q@1224|Proteobacteria,2VI37@28216|Betaproteobacteria,1JZVX@119060|Burkholderiaceae 28216|Betaproteobacteria C PFAM FAD linked oxidase domain protein - - - - - - - - - - - - ALO,FAD_binding_4 k59_1107879_2 477184.KYC_08050 4.66e-65 206.0 COG0300@1|root,COG0300@2|Bacteria,1NGXF@1224|Proteobacteria,2VPF9@28216|Betaproteobacteria 28216|Betaproteobacteria S Short-chain dehydrogenase reductase (SDR) - - - - - - - - - - - - adh_short k59_827029_1 1298863.AUEP01000003_gene2940 3.3e-54 191.0 COG1060@1|root,COG1060@2|Bacteria,2GK83@201174|Actinobacteria,4DN7M@85009|Propionibacteriales 201174|Actinobacteria H SMART Elongator protein 3 MiaB NifB fbiC - 2.5.1.77 ko:K11779 ko00680,ko01120,map00680,map01120 M00378 R09396 RC01381,RC03002,RC03007 ko00000,ko00001,ko00002,ko01000 - - - Radical_SAM k59_540706_1 13035.Dacsa_2870 2.4e-82 281.0 COG0737@1|root,COG2374@1|root,COG3391@1|root,COG4222@1|root,COG0737@2|Bacteria,COG2374@2|Bacteria,COG3391@2|Bacteria,COG4222@2|Bacteria,1G0YK@1117|Cyanobacteria 1117|Cyanobacteria K phosphatase - - - - - - - - - - - - 5_nucleotid_C,CHRD,DUF4114,DUF4214,Exo_endo_phos,Phytase-like,VPEP,W_rich_C k59_717079_1 1219031.BBJR01000001_gene591 3.92e-08 58.2 COG1589@1|root,COG1589@2|Bacteria,1N0T7@1224|Proteobacteria,2VRMV@28216|Betaproteobacteria,4A9Y5@80864|Comamonadaceae 28216|Betaproteobacteria D Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly ftsQ - - ko:K03589 ko04112,map04112 - - - ko00000,ko00001,ko03036 - - - FtsQ,POTRA_1 k59_717079_2 1395571.TMS3_0119270 9.61e-14 70.1 COG1181@1|root,COG1181@2|Bacteria,1MUTB@1224|Proteobacteria,1RMTM@1236|Gammaproteobacteria 1236|Gammaproteobacteria F Belongs to the D-alanine--D-alanine ligase family ddl - 6.3.2.4 ko:K01921 ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502 - R01150 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Dala_Dala_lig_C,Dala_Dala_lig_N k59_604041_1 1048834.TC41_3292 3.53e-44 159.0 COG0012@1|root,COG0012@2|Bacteria,1TPRK@1239|Firmicutes,4H9SQ@91061|Bacilli,277Y5@186823|Alicyclobacillaceae 91061|Bacilli J ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner ychF GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0044424,GO:0044464 - ko:K06942 - - - - ko00000,ko03009 - - - MMR_HSR1,YchF-GTPase_C k59_1731369_1 179408.Osc7112_4364 3.66e-35 138.0 COG0642@1|root,COG0784@1|root,COG2202@1|root,COG0784@2|Bacteria,COG2202@2|Bacteria,COG2205@2|Bacteria,1G09B@1117|Cyanobacteria,1H7M4@1150|Oscillatoriales 1117|Cyanobacteria T Signal transduction histidine kinase, subgroup 1, dimerisation phosphoacceptor domain - - - - - - - - - - - - HATPase_c,HisKA,PAS_3,PAS_4,PAS_9,Response_reg k59_485703_1 1219049.SP5_037_00290 1.18e-09 64.3 COG3250@1|root,COG3250@2|Bacteria,1MVBN@1224|Proteobacteria,2U222@28211|Alphaproteobacteria,2K19A@204457|Sphingomonadales 204457|Sphingomonadales G Beta galactosidase small chain - - - - - - - - - - - - Bgal_small_N,DUF4981,Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N k59_1565989_2 6087.XP_002154169.2 5.21e-09 62.0 KOG1591@1|root,KOG1591@2759|Eukaryota,38BMH@33154|Opisthokonta,3BA6F@33208|Metazoa 33208|Metazoa E procollagen-proline 4-dioxygenase activity - - 1.14.11.2 ko:K00472 ko00330,ko01100,map00330,map01100 - R01252 RC00478 ko00000,ko00001,ko01000 - - - 2OG-FeII_Oxy_3,P4Ha_N k59_1731378_1 515635.Dtur_1560 9.07e-55 198.0 COG0466@1|root,COG0466@2|Bacteria 2|Bacteria O ATP-dependent peptidase activity lon - 3.4.21.53 ko:K01338 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - AAA,LON_substr_bdg,Lon_C k59_485714_1 1230476.C207_00518 6.5e-22 99.8 COG0457@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2TRUI@28211|Alphaproteobacteria,3JR8W@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria T Adenylate cyclase - - - - - - - - - - - - BTAD,Guanylate_cyc,Trans_reg_C k59_1333473_1 436308.Nmar_1792 3.77e-143 419.0 COG0459@1|root,arCOG01257@2157|Archaea,41SDG@651137|Thaumarchaeota 651137|Thaumarchaeota O PFAM TCP-1 cpn60 chaperonin family - - - ko:K22447 - - - - ko00000,ko03110 - - - Cpn60_TCP1 k59_1167276_1 351348.Maqu_3557 3.82e-55 186.0 COG0548@1|root,COG1246@1|root,COG0548@2|Bacteria,COG1246@2|Bacteria,1MUUP@1224|Proteobacteria,1RMV5@1236|Gammaproteobacteria,46457@72275|Alteromonadaceae 1236|Gammaproteobacteria E Belongs to the acetyltransferase family. ArgA subfamily argA GO:0003674,GO:0003824,GO:0004042,GO:0004358,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.3.1.1 ko:K14682 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028 R00259 RC00004,RC00064 ko00000,ko00001,ko00002,ko01000 - - iECP_1309.ECP_2830,iLF82_1304.LF82_0116,iNRG857_1313.NRG857_13920,iYL1228.KPN_03226 AA_kinase,Acetyltransf_1 k59_39324_1 493475.GARC_3432 9.99e-36 132.0 2C3QV@1|root,2Z7YP@2|Bacteria,1MXAM@1224|Proteobacteria,1RNIA@1236|Gammaproteobacteria,4662K@72275|Alteromonadaceae 1236|Gammaproteobacteria S Alginate export - - - - - - - - - - - - Alginate_exp k59_717115_1 987059.RBXJA2T_17047 7.77e-139 408.0 COG1053@1|root,COG1053@2|Bacteria,1MU5M@1224|Proteobacteria,2VKSM@28216|Betaproteobacteria,1KNEK@119065|unclassified Burkholderiales 28216|Betaproteobacteria C Fumarate reductase flavoprotein C-term frdA - 1.3.5.4 ko:K00244 ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020 M00009,M00011,M00150,M00173 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,Succ_DH_flav_C k59_94922_1 1234364.AMSF01000095_gene2591 3.71e-36 139.0 COG1100@1|root,COG1100@2|Bacteria,1QXSV@1224|Proteobacteria,1S5FA@1236|Gammaproteobacteria,1X4RA@135614|Xanthomonadales 135614|Xanthomonadales S 50S ribosome-binding GTPase - - - ko:K06883 - - - - ko00000 - - - DUF697,MMR_HSR1 k59_1508456_1 439235.Dalk_1606 7.63e-28 114.0 COG1639@1|root,COG1639@2|Bacteria,1RAH3@1224|Proteobacteria,42PRF@68525|delta/epsilon subdivisions,2WP0E@28221|Deltaproteobacteria,2MJVK@213118|Desulfobacterales 28221|Deltaproteobacteria T HDOD domain - - - - - - - - - - - - HDOD k59_540740_1 1144275.COCOR_01938 4.96e-45 156.0 COG0483@1|root,COG0483@2|Bacteria,1MUQT@1224|Proteobacteria,42R1W@68525|delta/epsilon subdivisions,2WMQ4@28221|Deltaproteobacteria,2YVHS@29|Myxococcales 28221|Deltaproteobacteria G Inositol monophosphatase suhB - 3.1.3.25 ko:K01092 ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070 M00131 R01185,R01186,R01187 RC00078 ko00000,ko00001,ko00002,ko01000 - - - Inositol_P k59_206824_2 1209072.ALBT01000058_gene808 5.42e-25 94.4 COG0255@1|root,COG0255@2|Bacteria,1N6PR@1224|Proteobacteria,1SCBN@1236|Gammaproteobacteria,1FHQ8@10|Cellvibrio 1236|Gammaproteobacteria J Ribosomal L29 protein rpmC GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02904 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L29 k59_95804_1 314287.GB2207_00775 2.88e-77 260.0 COG2902@1|root,COG2902@2|Bacteria,1MXNV@1224|Proteobacteria,1RQVZ@1236|Gammaproteobacteria,1J56W@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E COG2902 NAD-specific glutamate dehydrogenase gdhB - 1.4.1.2 ko:K15371 ko00220,ko00250,ko00430,ko00910,ko01100,map00220,map00250,map00430,map00910,map01100 - R00243 RC00006,RC02799 ko00000,ko00001,ko01000 - - - Bac_GDH,GDH_N k59_1224228_1 882082.SaccyDRAFT_3811 1.4e-58 199.0 COG4626@1|root,COG4626@2|Bacteria,2IB7D@201174|Actinobacteria,4E8SB@85010|Pseudonocardiales 201174|Actinobacteria S Terminase - - - - - - - - - - - - Terminase_1 k59_1277466_1 1178825.ALIH01000012_gene1819 2.46e-45 164.0 COG0683@1|root,COG1388@1|root,COG0683@2|Bacteria,COG1388@2|Bacteria,4NG96@976|Bacteroidetes,1HY84@117743|Flavobacteriia 976|Bacteroidetes EM LysM domain lysM - - - - - - - - - - - ANF_receptor,LysM,Peripla_BP_6 k59_1168237_1 1122137.AQXF01000006_gene966 2.03e-25 96.7 COG0093@1|root,COG0093@2|Bacteria,1RCWZ@1224|Proteobacteria,2U743@28211|Alphaproteobacteria 28211|Alphaproteobacteria J Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome rplN GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070180,GO:0097159,GO:1901363,GO:1990904 - ko:K02874 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L14 k59_1168237_2 1122137.AQXF01000006_gene965 7.61e-62 190.0 COG0198@1|root,COG0198@2|Bacteria,1MZQD@1224|Proteobacteria,2UC6Y@28211|Alphaproteobacteria 28211|Alphaproteobacteria J One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit rplX GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02895 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - KOW,ribosomal_L24 k59_1168237_3 1122137.AQXF01000006_gene964 8.49e-116 333.0 COG0094@1|root,COG0094@2|Bacteria,1MUU9@1224|Proteobacteria,2TQPF@28211|Alphaproteobacteria 28211|Alphaproteobacteria J This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits rplE GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02931 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L5,Ribosomal_L5_C k59_1168237_4 1122137.AQXF01000006_gene963 4.67e-52 165.0 COG0199@1|root,COG0199@2|Bacteria,1MZDT@1224|Proteobacteria,2UC01@28211|Alphaproteobacteria 28211|Alphaproteobacteria J Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site rpsN GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02954 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S14 k59_323356_1 1030157.AFMP01000008_gene3260 6.82e-21 97.1 COG1301@1|root,COG1301@2|Bacteria,1MU0Q@1224|Proteobacteria,2TRET@28211|Alphaproteobacteria,2K103@204457|Sphingomonadales 204457|Sphingomonadales C Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family - - - - - - - - - - - - SDF k59_1168249_1 582744.Msip34_2351 1.18e-73 231.0 COG1054@1|root,COG1054@2|Bacteria,1MUFV@1224|Proteobacteria,2VIX6@28216|Betaproteobacteria,2KMBX@206350|Nitrosomonadales 206350|Nitrosomonadales S Belongs to the UPF0176 family - - - ko:K07146 - - - - ko00000 - - - Rhodanese k59_888178_1 743722.Sph21_0233 6.45e-46 154.0 COG1247@1|root,COG1247@2|Bacteria,4NNGH@976|Bacteroidetes,1ISBX@117747|Sphingobacteriia 976|Bacteroidetes M Acetyltransferase (GNAT) domain - - 2.3.1.183 ko:K03823 ko00440,ko01130,map00440,map01130 - R08871,R08938 RC00004,RC00064 ko00000,ko00001,ko01000 - - - Acetyltransf_1,Acetyltransf_4 k59_888178_3 237727.NAP1_03860 5.2e-18 82.0 COG5331@1|root,COG5331@2|Bacteria,1N0MD@1224|Proteobacteria,2UEP8@28211|Alphaproteobacteria,2KE6X@204457|Sphingomonadales 204457|Sphingomonadales S MAPEG family - - - - - - - - - - - - MAPEG k59_888178_4 1122137.AQXF01000005_gene1173 9.6e-35 122.0 COG3576@1|root,COG3576@2|Bacteria,1R8RC@1224|Proteobacteria,2TUXH@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Pyridoxamine 5-phosphate - - - - - - - - - - - - Putative_PNPOx k59_1784188_1 1283287.KB822578_gene2254 8.19e-22 97.1 COG0580@1|root,COG0580@2|Bacteria,2GKK3@201174|Actinobacteria,4DR8Z@85009|Propionibacteriales 201174|Actinobacteria G Major intrinsic protein aqpZ - - ko:K06188 - - - - ko00000,ko02000 1.A.8 - - MIP k59_1674094_1 1196322.A370_03667 5.2e-14 78.6 COG0515@1|root,COG2199@1|root,COG2203@1|root,COG2972@1|root,COG3899@1|root,COG0515@2|Bacteria,COG2199@2|Bacteria,COG2203@2|Bacteria,COG2972@2|Bacteria,COG3899@2|Bacteria,1TS5J@1239|Firmicutes,25EAF@186801|Clostridia 186801|Clostridia T Diguanylate cyclase (GGDEF) domain - - - - - - - - - - - - AAA_16,GAF,GGDEF,HAMP,HATPase_c,HisKA,PAS_3,PAS_9,Pkinase,Response_reg,SBP_bac_3,dCache_1 k59_95838_1 344747.PM8797T_13992 4.37e-28 125.0 COG0457@1|root,COG0457@2|Bacteria,2IWZ3@203682|Planctomycetes 203682|Planctomycetes S Oxygen tolerance - - - - - - - - - - - - BatD k59_1566864_1 1229909.NSED_08925 1.5e-240 676.0 arCOG08793@1|root,arCOG08812@1|root,arCOG08793@2157|Archaea,arCOG08812@2157|Archaea,41SXB@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_40109_1 1282876.BAOK01000001_gene3204 6.05e-80 248.0 COG2030@1|root,COG2030@2|Bacteria,1MUR2@1224|Proteobacteria,2TUM7@28211|Alphaproteobacteria 28211|Alphaproteobacteria I dehydratase MA20_35600 - - - - - - - - - - - MaoC_dehydrat_N,MaoC_dehydratas k59_939215_1 436308.Nmar_0746 5.29e-79 241.0 COG2107@1|root,arCOG00654@2157|Archaea,41SB8@651137|Thaumarchaeota 651137|Thaumarchaeota H Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2) mqnD - - ko:K11785 ko00130,ko01110,map00130,map01110 - R08589 RC02330 ko00000,ko00001,ko01000 - - - VitK2_biosynth k59_264963_1 257310.BB3134 4.77e-62 207.0 COG0028@1|root,COG0028@2|Bacteria,1MXG0@1224|Proteobacteria,2W14W@28216|Betaproteobacteria,3T3F3@506|Alcaligenaceae 1224|Proteobacteria EH Thiamine pyrophosphate enzyme, central domain - - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_1509427_1 1387312.BAUS01000004_gene1676 2.5e-81 250.0 COG1305@1|root,COG1305@2|Bacteria,1MVMI@1224|Proteobacteria,2VH3S@28216|Betaproteobacteria,2KKHH@206350|Nitrosomonadales 206350|Nitrosomonadales E Transglutaminase/protease-like homologues - - - - - - - - - - - - Bact_transglu_N,Transglut_core k59_40121_1 1117647.M5M_13595 1.66e-69 233.0 COG1629@1|root,COG4771@2|Bacteria,1MU9K@1224|Proteobacteria,1RMTG@1236|Gammaproteobacteria,1J5SV@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P COG1629 Outer membrane receptor proteins, mostly Fe transport - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_264968_1 865937.Gilli_0403 2.98e-132 389.0 COG0506@1|root,COG0506@2|Bacteria,4NEH5@976|Bacteroidetes,1HWSR@117743|Flavobacteriia,2P685@244698|Gillisia 976|Bacteroidetes E Proline dehydrogenase putA - - ko:K00318 ko00330,ko01100,ko01110,ko01130,map00330,map01100,map01110,map01130 - R10507 RC00083 ko00000,ko00001,ko01000 - - - Pro_dh k59_541738_1 648757.Rvan_2056 1.07e-102 307.0 28K0U@1|root,2Z9QP@2|Bacteria,1R4IB@1224|Proteobacteria,2UIF7@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_656718_1 566466.NOR53_2601 4.98e-72 219.0 COG1734@1|root,COG1734@2|Bacteria,1RD08@1224|Proteobacteria,1S47H@1236|Gammaproteobacteria,1J620@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters. Also required for regulation of fis expression dksA GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - ko:K06204 ko02026,map02026 - - - ko00000,ko00001,ko03000,ko03009,ko03021 - - - zf-dskA_traR k59_1509430_1 1121921.KB898708_gene1324 2.47e-36 130.0 COG0565@1|root,COG0565@2|Bacteria,1N47Y@1224|Proteobacteria,1RPD3@1236|Gammaproteobacteria,2PMN9@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria J SpoU rRNA Methylase family trmJ - 2.1.1.200 ko:K02533,ko:K15396 - - - - ko00000,ko01000,ko03016 - - - SpoU_methylase k59_1509430_2 747.DR93_1091 4.51e-14 68.2 COG1959@1|root,COG1959@2|Bacteria,1RDA4@1224|Proteobacteria,1S3RW@1236|Gammaproteobacteria,1Y8MI@135625|Pasteurellales 135625|Pasteurellales K Regulates the transcription of several operons and genes involved in the biogenesis of Fe-S clusters and Fe-S-containing proteins iscR - - ko:K13643 - - - - ko00000,ko03000 - - - Rrf2 k59_150178_1 588932.JHOF01000018_gene710 5.89e-33 120.0 COG2259@1|root,COG2259@2|Bacteria,1N072@1224|Proteobacteria,2UCXT@28211|Alphaproteobacteria,2KJ9S@204458|Caulobacterales 204458|Caulobacterales S PFAM DoxX family protein - - - ko:K15977 - - - - ko00000 - - - DoxX k59_1619825_1 743719.PaelaDRAFT_5872 5.42e-75 237.0 COG0148@1|root,COG0148@2|Bacteria,1TP2S@1239|Firmicutes,4HAKI@91061|Bacilli,26REN@186822|Paenibacillaceae 91061|Bacilli G Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis eno GO:0001968,GO:0003674,GO:0003824,GO:0004634,GO:0005488,GO:0005515,GO:0005518,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009986,GO:0009987,GO:0016052,GO:0016053,GO:0016310,GO:0016829,GO:0016835,GO:0016836,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0019899,GO:0030312,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0035375,GO:0042866,GO:0043236,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0044877,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0050840,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0071944,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576 4.2.1.11 ko:K01689 ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066 M00001,M00002,M00003,M00346,M00394 R00658 RC00349 ko00000,ko00001,ko00002,ko01000,ko03019,ko04147 - - - Enolase_C,Enolase_N k59_1056377_1 95619.PM1_0222735 6.85e-37 141.0 COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,1RMBQ@1236|Gammaproteobacteria 1236|Gammaproteobacteria C belongs to the aldehyde dehydrogenase family pedI - - ko:K00138 ko00010,ko00620,ko01100,ko01110,ko01120,map00010,map00620,map01100,map01110,map01120 - R00711 RC00047 ko00000,ko00001,ko01000 - - - Aldedh k59_827924_1 1282876.BAOK01000001_gene980 1.19e-41 146.0 COG2175@1|root,COG2175@2|Bacteria,1MV5K@1224|Proteobacteria,2TQTZ@28211|Alphaproteobacteria,4BQDS@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria Q Taurine catabolism dioxygenase TauD, TfdA family - - 1.14.11.17 ko:K03119 ko00430,ko00920,map00430,map00920 - R05320 RC01331 ko00000,ko00001,ko01000 - - - TauD k59_827924_2 1205680.CAKO01000004_gene3679 3.49e-13 67.8 COG1024@1|root,COG1024@2|Bacteria,1MWZC@1224|Proteobacteria,2TRIH@28211|Alphaproteobacteria 28211|Alphaproteobacteria I Belongs to the enoyl-CoA hydratase isomerase family MA20_16365 - 4.2.1.149 ko:K08299 - - R10675 RC01095 ko00000,ko01000 - - - ECH_1 k59_604975_1 926560.KE387027_gene881 9.21e-130 377.0 COG0031@1|root,COG0031@2|Bacteria,1WJ3S@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus E Belongs to the cysteine synthase cystathionine beta- synthase family - - 2.5.1.47 ko:K01738 ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230 M00021 R00897,R03601,R04859 RC00020,RC02814,RC02821 ko00000,ko00001,ko00002,ko01000 - - - PALP k59_264995_1 1353276.JADR01000001_gene680 2.59e-62 201.0 2D1GA@1|root,32TAN@2|Bacteria,4NSH6@976|Bacteroidetes,1I2BP@117743|Flavobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_1509452_1 1123073.KB899241_gene1962 1.42e-27 109.0 COG1595@1|root,COG1595@2|Bacteria,1MVPD@1224|Proteobacteria,1SC6Q@1236|Gammaproteobacteria,1X520@135614|Xanthomonadales 135614|Xanthomonadales K Belongs to the sigma-70 factor family. ECF subfamily rpoE4 - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4,Sigma70_r4_2 k59_95882_1 1209072.ALBT01000028_gene1238 5.73e-12 72.4 COG0591@1|root,COG0591@2|Bacteria,1MUBI@1224|Proteobacteria,1RXW2@1236|Gammaproteobacteria,1FHYK@10|Cellvibrio 1236|Gammaproteobacteria E Sodium:solute symporter family - - - - - - - - - - - - SSF k59_47626_1 1090318.ATTI01000001_gene3143 2.32e-73 246.0 COG0726@1|root,COG1215@1|root,COG3858@1|root,COG0726@2|Bacteria,COG1215@2|Bacteria,COG3858@2|Bacteria,1MXG7@1224|Proteobacteria,2TVZ5@28211|Alphaproteobacteria,2K1ER@204457|Sphingomonadales 204457|Sphingomonadales GM Polysaccharide deacetylase - - 3.5.1.104 ko:K22278 - - - - ko00000,ko01000 - - - Glyco_hydro_18,Glyco_tranf_2_3,Polysacc_deac_1 k59_726149_1 626887.J057_14445 5.83e-58 202.0 COG4796@1|root,COG4796@2|Bacteria,1QTT6@1224|Proteobacteria,1RN3Z@1236|Gammaproteobacteria,465HK@72275|Alteromonadaceae 1236|Gammaproteobacteria U COG4796 Type II secretory pathway, component HofQ pilQ GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006139,GO:0006259,GO:0006308,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0015976,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901361,GO:1901363,GO:1901575 - ko:K02507,ko:K02666 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - AMIN,STN,Secretin,Secretin_N k59_1574662_1 472759.Nhal_3460 2.04e-36 136.0 COG1988@1|root,COG1988@2|Bacteria,1R5QP@1224|Proteobacteria,1S64C@1236|Gammaproteobacteria,1X05J@135613|Chromatiales 135613|Chromatiales S membrane-bound metal-dependent - - - ko:K07038 - - - - ko00000 - - - YdjM k59_1116926_1 450851.PHZ_c1920 1.21e-19 88.2 COG3173@1|root,COG3173@2|Bacteria,1MY0Y@1224|Proteobacteria,2TRMW@28211|Alphaproteobacteria,2KFT2@204458|Caulobacterales 204458|Caulobacterales S Phosphotransferase enzyme family - - - - - - - - - - - - APH k59_1116926_2 882083.SacmaDRAFT_2999 4.76e-10 63.5 COG3173@1|root,COG3173@2|Bacteria,2HU7E@201174|Actinobacteria,4DYKS@85010|Pseudonocardiales 201174|Actinobacteria S Phosphotransferase enzyme family - - - - - - - - - - - - APH k59_1116940_1 1122137.AQXF01000002_gene260 1.22e-30 120.0 COG1562@1|root,COG1562@2|Bacteria,1MX4W@1224|Proteobacteria,2U08T@28211|Alphaproteobacteria 28211|Alphaproteobacteria I Phytoene squalene synthetase crtB - 2.5.1.32,2.5.1.99 ko:K02291,ko:K18163 ko00906,ko01062,ko01100,ko01110,ko04714,map00906,map01062,map01100,map01110,map04714 M00097 R02065,R04218,R07270,R10177 RC00362,RC01101,RC02869 ko00000,ko00001,ko00002,ko01000,ko01006,ko03029 - - - SQS_PSY k59_1231598_1 1163617.SCD_n00311 2e-94 283.0 COG0253@1|root,COG0253@2|Bacteria,1MWDH@1224|Proteobacteria,2VI0C@28216|Betaproteobacteria 28216|Betaproteobacteria E Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan dapF GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008837,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016853,GO:0016854,GO:0016855,GO:0019752,GO:0036361,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0047661,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.1.1.7 ko:K01778 ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00527 R02735 RC00302 ko00000,ko00001,ko00002,ko01000 - - - DAP_epimerase k59_549942_1 1117647.M5M_19330 4.71e-28 108.0 COG2111@1|root,COG2111@2|Bacteria,1N1CK@1224|Proteobacteria,1RR3K@1236|Gammaproteobacteria,1J5HN@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P COG2111 Multisubunit Na H antiporter, MnhB subunit - - - ko:K05566 - - - - ko00000,ko02000 2.A.63.1,2.A.63.2 - - DUF4040,MnhB k59_549942_2 2340.JV46_13170 1.6e-55 177.0 COG2111@1|root,COG2111@2|Bacteria,1N1CK@1224|Proteobacteria,1RR3K@1236|Gammaproteobacteria,1J5HN@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P COG2111 Multisubunit Na H antiporter, MnhB subunit - - - - - - - - - - - - DUF4040,MnhB k59_549942_3 1304275.C41B8_05758 1.71e-06 48.1 COG1006@1|root,COG1006@2|Bacteria,1RGU1@1224|Proteobacteria,1S6BB@1236|Gammaproteobacteria 1236|Gammaproteobacteria P NADH-ubiquinone oxidoreductase, chain 4L - - - ko:K05567 - - - - ko00000,ko02000 2.A.63.1,2.A.63.2 - - Oxidored_q2 k59_1175608_1 882.DVU_1258 6.08e-51 181.0 COG3968@1|root,COG3968@2|Bacteria,1QUKF@1224|Proteobacteria,42PBH@68525|delta/epsilon subdivisions,2WJZG@28221|Deltaproteobacteria,2M9AA@213115|Desulfovibrionales 28221|Deltaproteobacteria S Glutamine synthetase, catalytic region glnN - 6.3.1.2 ko:K01915 ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 - R00253 RC00010,RC02798 ko00000,ko00001,ko01000,ko04147 - - - GSIII_N,Gln-synt_C k59_896345_1 1232683.ADIMK_1266 7.25e-131 399.0 COG0525@1|root,COG0525@2|Bacteria,1MV7B@1224|Proteobacteria,1RNEB@1236|Gammaproteobacteria,465F9@72275|Alteromonadaceae 1236|Gammaproteobacteria J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner valS GO:0000287,GO:0002161,GO:0003674,GO:0003824,GO:0004812,GO:0004832,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006417,GO:0006418,GO:0006438,GO:0006450,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0016070,GO:0016787,GO:0016788,GO:0016874,GO:0016875,GO:0019222,GO:0019538,GO:0019752,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0034248,GO:0034250,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045727,GO:0045903,GO:0046483,GO:0046872,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0052689,GO:0060255,GO:0061475,GO:0065007,GO:0065008,GO:0071704,GO:0080090,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:2000112 6.1.1.9 ko:K01873 ko00970,map00970 M00359,M00360 R03665 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iECH74115_1262.ECH74115_5779,iECNA114_1301.ECNA114_4481,iECO26_1355.ECO26_5428,iECSP_1301.ECSP_5359,iECs_1301.ECs5235,iG2583_1286.G2583_5088,iJN746.PP_0977,iSBO_1134.SBO_4182,iSSON_1240.SSON_4443,iYL1228.KPN_04663,iZ_1308.Z5870 Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1 k59_1739903_2 765913.ThidrDRAFT_3254 8.83e-50 176.0 COG0376@1|root,COG0376@2|Bacteria,1MUBF@1224|Proteobacteria,1RNA5@1236|Gammaproteobacteria,1WWMA@135613|Chromatiales 135613|Chromatiales P Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity katG - 1.11.1.21 ko:K03782 ko00360,ko00380,ko00940,ko00983,ko01100,ko01110,map00360,map00380,map00940,map00983,map01100,map01110 - R00602,R00698,R02596,R02670,R03919,R04007,R07443,R11906 RC00034,RC00213,RC00767,RC02141 ko00000,ko00001,ko01000 - - - peroxidase k59_1682788_1 566466.NOR53_2818 1.45e-26 112.0 COG0689@1|root,COG0810@1|root,COG3210@1|root,COG4932@1|root,COG0689@2|Bacteria,COG0810@2|Bacteria,COG3210@2|Bacteria,COG4932@2|Bacteria,1QUXB@1224|Proteobacteria 1224|Proteobacteria U 6-phosphogluconolactonase activity - - - - - - - - - - - - Big_5,Cadherin_3,Calx-beta,DUF11,DUF4347,He_PIG,OmpA_membrane,PATR,VCBS k59_494371_1 1121930.AQXG01000016_gene1818 1.09e-131 396.0 COG1757@1|root,COG1757@2|Bacteria,4NFF8@976|Bacteroidetes 976|Bacteroidetes C Na H anti-porter mleN - - - - - - - - - - - Na_H_antiporter k59_47648_1 395963.Bind_2848 1.41e-69 220.0 COG4122@1|root,COG4122@2|Bacteria,1RDAN@1224|Proteobacteria,2TYBD@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Macrocin-O-methyltransferase (TylF) - - - - - - - - - - - - TylF k59_47648_2 936136.ARRT01000006_gene3012 1.25e-28 112.0 COG3568@1|root,COG3568@2|Bacteria,1Q1Q1@1224|Proteobacteria,2U28J@28211|Alphaproteobacteria,4BAH9@82115|Rhizobiaceae 28211|Alphaproteobacteria S endonuclease exonuclease phosphatase - - - - - - - - - - - - Exo_endo_phos k59_1517306_2 1282876.BAOK01000001_gene3446 9.57e-11 64.3 COG0204@1|root,COG0560@1|root,COG0204@2|Bacteria,COG0560@2|Bacteria,1MY51@1224|Proteobacteria,2UI5H@28211|Alphaproteobacteria 28211|Alphaproteobacteria I Phosphate acyltransferases - - 2.3.1.51,3.1.3.3 ko:K15781 - - - - ko00000,ko01000 - - - Acyltransferase,HAD k59_1231600_1 1463881.KL591004_gene4026 5.22e-32 115.0 COG1476@1|root,COG1476@2|Bacteria,2GQIU@201174|Actinobacteria 201174|Actinobacteria K PFAM helix-turn-helix domain protein - - - ko:K07729 - - - - ko00000,ko03000 - - - HTH_3 k59_1002787_2 1335757.SPICUR_01350 1.87e-36 137.0 COG2853@1|root,COG2853@2|Bacteria,1MVX0@1224|Proteobacteria,1RNPS@1236|Gammaproteobacteria,1WW1D@135613|Chromatiales 135613|Chromatiales M PFAM VacJ family lipoprotein - - - ko:K04754 - - - - ko00000 - - - MlaA k59_216326_1 436308.Nmar_0975 1.12e-06 50.1 COG1602@1|root,arCOG04269@2157|Archaea,41S7H@651137|Thaumarchaeota 651137|Thaumarchaeota S Archaeal Nre, N-terminal - - - - - - - - - - - - Nre_C,Nre_N k59_727316_1 436308.Nmar_0444 5.61e-113 343.0 COG1215@1|root,arCOG01389@2157|Archaea,41SDD@651137|Thaumarchaeota 651137|Thaumarchaeota M Glycosyl transferase family group 2 - - - - - - - - - - - - Glyco_tranf_2_3 k59_274276_1 1096930.L284_21565 6.39e-130 387.0 COG1154@1|root,COG1154@2|Bacteria,1MUSJ@1224|Proteobacteria,2TRDD@28211|Alphaproteobacteria,2K0XY@204457|Sphingomonadales 204457|Sphingomonadales H Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) dxs - 2.2.1.7 ko:K01662 ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130 M00096 R05636 RC00032 ko00000,ko00001,ko00002,ko01000 - - - DXP_synthase_N,Transket_pyr,Transketolase_C k59_104627_1 1123065.ATWL01000002_gene1503 1.2e-67 218.0 COG3639@1|root,COG3639@2|Bacteria,2IAPI@201174|Actinobacteria 201174|Actinobacteria P ABC-type phosphate phosphonate transport system permease component - - - ko:K02042 ko02010,map02010 M00223 - - ko00000,ko00001,ko00002,ko02000 3.A.1.9 - - BPD_transp_1 k59_1740937_1 330214.NIDE3558 8.85e-66 200.0 COG0316@1|root,COG0316@2|Bacteria,3J0TZ@40117|Nitrospirae 40117|Nitrospirae S Belongs to the HesB IscA family - - - ko:K15724 - - - - ko00000 - - - Fe-S_biosyn k59_1117954_1 272560.BPSS1381 4.19e-32 129.0 COG0398@1|root,COG1502@1|root,COG0398@2|Bacteria,COG1502@2|Bacteria,1MV8I@1224|Proteobacteria,2VHM3@28216|Betaproteobacteria,1JZPX@119060|Burkholderiaceae 28216|Betaproteobacteria I phospholipase D - - 3.1.4.4 ko:K01115 ko00564,ko00565,ko01100,ko01110,ko04014,ko04024,ko04071,ko04072,ko04144,ko04666,ko04724,ko04912,ko05231,map00564,map00565,map01100,map01110,map04014,map04024,map04071,map04072,map04144,map04666,map04724,map04912,map05231 - R01310,R02051,R07385 RC00017,RC00425 ko00000,ko00001,ko01000,ko04131 - - - PLDc,PLDc_2,SNARE_assoc k59_727325_1 436308.Nmar_1714 6.3e-17 79.0 COG4591@1|root,arCOG02313@2157|Archaea,41TBB@651137|Thaumarchaeota 651137|Thaumarchaeota M FtsX-like permease family - - - ko:K09808 ko02010,map02010 M00255 - - ko00000,ko00001,ko00002,ko02000 3.A.1.125 - - FtsX,MacB_PCD k59_727325_2 436308.Nmar_1715 2.05e-42 147.0 COG1522@1|root,arCOG01586@2157|Archaea,41T3N@651137|Thaumarchaeota 651137|Thaumarchaeota K AsnC-type helix-turn-helix domain - - - - - - - - - - - - HTH_24 k59_551004_1 1122137.AQXF01000003_gene2376 7.61e-113 328.0 COG0491@1|root,COG0491@2|Bacteria,1MUDN@1224|Proteobacteria,2TQJ9@28211|Alphaproteobacteria 28211|Alphaproteobacteria S COG0491 Zn-dependent hydrolases, including glyoxylases ycbL GO:0003674,GO:0003824,GO:0004416,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006082,GO:0006089,GO:0008150,GO:0008152,GO:0009056,GO:0009438,GO:0009987,GO:0016787,GO:0016788,GO:0016790,GO:0019243,GO:0019752,GO:0032787,GO:0042180,GO:0042182,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046185,GO:0051596,GO:0061727,GO:0071704,GO:1901575,GO:1901615 - - - - - - - - - - Lactamase_B k59_1003791_1 1123368.AUIS01000005_gene303 2.64e-45 160.0 COG0232@1|root,COG0232@2|Bacteria,1MVQ2@1224|Proteobacteria,1RPVJ@1236|Gammaproteobacteria,2NCE1@225057|Acidithiobacillales 225057|Acidithiobacillales F Belongs to the dGTPase family. Type 2 subfamily - - 3.1.5.1 ko:K01129 ko00230,map00230 - R01856 RC00017 ko00000,ko00001,ko01000 - - - HD,HD_assoc k59_1003791_2 686340.Metal_1547 4.8e-109 320.0 COG0284@1|root,COG0284@2|Bacteria,1MW2C@1224|Proteobacteria,1RNJR@1236|Gammaproteobacteria,1XEBB@135618|Methylococcales 135618|Methylococcales F Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) pyrF GO:0003674,GO:0003824,GO:0004590,GO:0006139,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.1.23 ko:K01591 ko00240,ko01100,map00240,map01100 M00051 R00965 RC00409 ko00000,ko00001,ko00002,ko01000 - - - OMPdecase k59_48690_1 882083.SacmaDRAFT_2401 1.49e-32 129.0 COG3333@1|root,COG3333@2|Bacteria,2GJB2@201174|Actinobacteria,4E9ZB@85010|Pseudonocardiales 201174|Actinobacteria S Tripartite tricarboxylate transporter TctA family - - - ko:K07793 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.80.1 - - TctA k59_1003793_1 498211.CJA_2227 2e-132 394.0 COG0504@1|root,COG0504@2|Bacteria,1MUIT@1224|Proteobacteria,1RM92@1236|Gammaproteobacteria,1FG88@10|Cellvibrio 1236|Gammaproteobacteria F Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates pyrG GO:0003674,GO:0003824,GO:0003883,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006213,GO:0006220,GO:0006221,GO:0006241,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009208,GO:0009209,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046036,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 6.3.4.2 ko:K01937 ko00240,ko01100,map00240,map01100 M00052 R00571,R00573 RC00010,RC00074 ko00000,ko00001,ko00002,ko01000 - - iECO103_1326.ECO103_3323,iPC815.YPO3377 CTP_synth_N,GATase k59_666301_1 1088721.NSU_0715 4.01e-20 92.4 COG0790@1|root,COG3147@1|root,COG0790@2|Bacteria,COG3147@2|Bacteria,1RJ71@1224|Proteobacteria,2U15P@28211|Alphaproteobacteria,2K032@204457|Sphingomonadales 204457|Sphingomonadales S FOG TPR repeat, SEL1 subfamily - - - ko:K07126 - - - - ko00000 - - - SPOR,Sel1 k59_1287140_1 702113.PP1Y_AT2262 1.32e-104 315.0 COG0312@1|root,COG0312@2|Bacteria,1MUSK@1224|Proteobacteria,2TRSR@28211|Alphaproteobacteria,2JZY8@204457|Sphingomonadales 204457|Sphingomonadales S peptidase U62, modulator of DNA gyrase tldD - - ko:K03568 - - - - ko00000,ko01002 - - - PmbA_TldD k59_948207_2 1229909.NSED_01435 1.07e-43 146.0 arCOG08747@1|root,arCOG08747@2157|Archaea,41T48@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1740947_1 1120792.JAFV01000001_gene2600 1.06e-07 55.8 COG2266@1|root,COG2266@2|Bacteria,1RFQ8@1224|Proteobacteria,2U7WE@28211|Alphaproteobacteria 28211|Alphaproteobacteria H MobA-like NTP transferase domain - - - - - - - - - - - - NTP_transf_3 k59_1065150_1 1500897.JQNA01000002_gene1046 4.54e-29 112.0 COG3794@1|root,COG3794@2|Bacteria,1RH5A@1224|Proteobacteria,2VSEN@28216|Betaproteobacteria,1K851@119060|Burkholderiaceae 28216|Betaproteobacteria C Domain of unknown function (DUF4399) - - - - - - - - - - - - DUF4399 k59_1065151_1 1123368.AUIS01000021_gene1000 1.75e-114 340.0 COG0055@1|root,COG0055@2|Bacteria,1MUFU@1224|Proteobacteria,1RN6U@1236|Gammaproteobacteria,2NCIZ@225057|Acidithiobacillales 225057|Acidithiobacillales C Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits atpD - 3.6.3.14 ko:K02112 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - - ATP-synt_ab,ATP-synt_ab_N k59_1343403_1 864051.BurJ1DRAFT_3189 9.36e-69 221.0 COG0381@1|root,COG0381@2|Bacteria,1QUYI@1224|Proteobacteria,2WFJ1@28216|Betaproteobacteria,1KJTK@119065|unclassified Burkholderiales 28216|Betaproteobacteria G Belongs to the UDP-N-acetylglucosamine 2-epimerase family wecB - 5.1.3.14 ko:K01791 ko00520,ko01100,ko05111,map00520,map01100,map05111 M00362 R00420 RC00290 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Epimerase_2 k59_1117974_1 857087.Metme_0993 7.08e-52 189.0 COG0515@1|root,COG0515@2|Bacteria,1PJRR@1224|Proteobacteria,1RMDQ@1236|Gammaproteobacteria,1XE9V@135618|Methylococcales 1236|Gammaproteobacteria KLT Tyrosine-protein kinase, subgroup, catalytic domain - - - - - - - - - - - - DUF1566,FGE-sulfatase,Pkinase k59_666312_1 1415778.JQMM01000001_gene1050 4.04e-118 342.0 COG0209@1|root,COG0209@2|Bacteria,1P4EH@1224|Proteobacteria,1RP1A@1236|Gammaproteobacteria,1J553@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria F COG0209 Ribonucleotide reductase, alpha subunit nrdJb - - - - - - - - - - - - k59_1456880_1 740709.A10D4_08809 1.46e-72 234.0 COG1680@1|root,COG1680@2|Bacteria,1MY4Y@1224|Proteobacteria,1RY1C@1236|Gammaproteobacteria,2QFNS@267893|Idiomarinaceae 1236|Gammaproteobacteria V Beta-lactamase - - - - - - - - - - - - Beta-lactamase k59_389035_1 1279015.KB908454_gene846 9.64e-56 194.0 COG3563@1|root,COG3563@2|Bacteria,1MW0T@1224|Proteobacteria,1RPMS@1236|Gammaproteobacteria,1Y50E@135624|Aeromonadales 135624|Aeromonadales M Capsule polysaccharide biosynthesis protein - - - ko:K07266 - - - - ko00000 - - - Capsule_synth k59_159098_1 1122137.AQXF01000001_gene2911 2.39e-93 281.0 COG2816@1|root,COG2816@2|Bacteria,1QGCX@1224|Proteobacteria,2TVMG@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Belongs to the Nudix hydrolase family nudC - 3.6.1.22 ko:K03426 ko00760,ko01100,ko04146,map00760,map01100,map04146 - R00103,R03004,R11104 RC00002 ko00000,ko00001,ko01000 - - - NUDIX,NUDIX-like,zf-NADH-PPase k59_389037_1 465817.ETA_17240 1.69e-43 154.0 COG0753@1|root,COG0753@2|Bacteria,1MUXZ@1224|Proteobacteria,1RNE7@1236|Gammaproteobacteria,3X66X@551|Erwinia 1236|Gammaproteobacteria C Belongs to the catalase family katA - 1.11.1.6 ko:K03781 ko00380,ko00630,ko01110,ko01130,ko01200,ko04011,ko04016,ko04068,ko04146,ko04211,ko04212,ko04213,ko05014,map00380,map00630,map01110,map01130,map01200,map04011,map04016,map04068,map04146,map04211,map04212,map04213,map05014 M00532 R00009,R00602,R02670 RC00034,RC00767,RC02141,RC02755 ko00000,ko00001,ko00002,ko01000 - - - Catalase,Catalase-rel k59_1456884_1 1437448.AZRT01000012_gene705 4.35e-05 45.1 COG2070@1|root,COG2070@2|Bacteria,1MU0U@1224|Proteobacteria,2TS5U@28211|Alphaproteobacteria,1J1DB@118882|Brucellaceae 28211|Alphaproteobacteria S FMN-dependent dehydrogenase MA20_20850 - 1.13.12.16 ko:K00459 ko00910,map00910 - R00025 RC02541,RC02759 ko00000,ko00001,ko01000 - - - NMO k59_1456884_2 1123257.AUFV01000002_gene2617 3.02e-18 90.9 COG4235@1|root,COG4235@2|Bacteria,1MY4J@1224|Proteobacteria,1RZEA@1236|Gammaproteobacteria,1X3KB@135614|Xanthomonadales 135614|Xanthomonadales O Cytochrome C biogenesis cycH - - ko:K02200 - - - - ko00000 - - - TPR_16,TPR_19,TPR_2 k59_389043_1 1297742.A176_03489 1.07e-249 721.0 COG0436@1|root,COG2890@1|root,COG0436@2|Bacteria,COG2890@2|Bacteria,1P71G@1224|Proteobacteria,4392Z@68525|delta/epsilon subdivisions,2X48U@28221|Deltaproteobacteria,2YYI8@29|Myxococcales 28221|Deltaproteobacteria EJ Pfam:Methyltransf_26 - - - - - - - - - - - - Aminotran_1_2 k59_1343425_1 436308.Nmar_0410 7.21e-41 136.0 arCOG08666@1|root,arCOG08666@2157|Archaea,41SVR@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1343425_2 436308.Nmar_0409 9.81e-83 258.0 COG0579@1|root,arCOG00754@2157|Archaea,41SXA@651137|Thaumarchaeota 651137|Thaumarchaeota S FAD dependent oxidoreductase - - - ko:K15736 - - - - ko00000,ko01000 - - - DAO k59_159114_1 551789.ATVJ01000002_gene2998 1.74e-52 186.0 COG4773@1|root,COG4773@2|Bacteria,1QTXJ@1224|Proteobacteria,2UQ22@28211|Alphaproteobacteria,43WUA@69657|Hyphomonadaceae 28211|Alphaproteobacteria P TonB dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_389046_1 522306.CAP2UW1_2584 6.28e-31 118.0 COG1013@1|root,COG1013@2|Bacteria,1R5BF@1224|Proteobacteria,2VIQM@28216|Betaproteobacteria 28216|Betaproteobacteria C PFAM Thiamine pyrophosphate - - 1.2.7.11,1.2.7.3 ko:K00175 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C k59_1343436_1 204669.Acid345_0159 7.51e-53 176.0 COG1606@1|root,COG1606@2|Bacteria,3Y30C@57723|Acidobacteria,2JKD3@204432|Acidobacteriia 204432|Acidobacteriia L tRNA processing - - - ko:K06864 - - - - ko00000 - - - NAD_synthase k59_1518372_1 1173026.Glo7428_2152 1.14e-13 72.4 COG0405@1|root,COG0405@2|Bacteria,1G20A@1117|Cyanobacteria 1117|Cyanobacteria E PFAM Gamma-glutamyltranspeptidase ggt - 2.3.2.2,3.4.19.13 ko:K00681 ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100 - R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935 RC00064,RC00090,RC00096 ko00000,ko00001,ko01000,ko01002 - - - G_glu_transpept k59_1518372_2 243233.MCA2148 3.05e-25 106.0 COG0405@1|root,COG0405@2|Bacteria,1MUV6@1224|Proteobacteria,1RMIT@1236|Gammaproteobacteria,1XENK@135618|Methylococcales 135618|Methylococcales M Gamma-glutamyltranspeptidase - - 2.3.2.2,3.4.19.13 ko:K00681 ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100 - R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935 RC00064,RC00090,RC00096 ko00000,ko00001,ko01000,ko01002 - - - G_glu_transpept k59_1232699_1 1229909.NSED_09145 1.92e-103 307.0 COG0704@1|root,arCOG00318@2157|Archaea,41T1H@651137|Thaumarchaeota 651137|Thaumarchaeota P Phosphate uptake regulator - - - - - - - - - - - - PhoU k59_439976_1 1049564.TevJSym_au00430 3.08e-53 186.0 COG0741@1|root,COG1388@1|root,COG0741@2|Bacteria,COG1388@2|Bacteria,1MWKE@1224|Proteobacteria,1RMFZ@1236|Gammaproteobacteria,1J524@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains) mltD GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0008150,GO:0008932,GO:0008933,GO:0009893,GO:0016020,GO:0016740,GO:0016757,GO:0019222,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043085,GO:0044093,GO:0044464,GO:0048518,GO:0050789,GO:0050790,GO:0051341,GO:0051353,GO:0061783,GO:0065007,GO:0065009 - ko:K08307 - - - - ko00000,ko01000,ko01011 - - - LysM,SLT k59_439976_2 443152.MDG893_06650 1.16e-15 74.7 COG0623@1|root,COG0623@2|Bacteria,1MV05@1224|Proteobacteria,1RNMW@1236|Gammaproteobacteria,46AM0@72275|Alteromonadaceae 1236|Gammaproteobacteria I Enoyl- acyl-carrier-protein reductase NADH fabI GO:0003674,GO:0003824,GO:0004312,GO:0004318,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016043,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0016740,GO:0016746,GO:0016747,GO:0017144,GO:0018130,GO:0019752,GO:0022607,GO:0030497,GO:0032787,GO:0034641,GO:0042364,GO:0042802,GO:0043436,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 1.3.1.10,1.3.1.9 ko:K00208 ko00061,ko00333,ko00780,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01100,map01130,map01212 M00083,M00572 R01404,R04429,R04430,R04724,R04725,R04955,R04956,R04958,R04959,R04961,R04962,R04966,R04967,R04969,R04970,R07765,R10118,R10122,R11671 RC00052,RC00076,RC00120 ko00000,ko00001,ko00002,ko01000,ko01004 - - iECUMN_1333.ECUMN_1592 adh_short_C2 k59_1405897_1 1123253.AUBD01000008_gene556 4.12e-95 300.0 COG3827@1|root,COG3827@2|Bacteria,1QQR0@1224|Proteobacteria,1S068@1236|Gammaproteobacteria,1X3QQ@135614|Xanthomonadales 135614|Xanthomonadales - - - - - - - - - - - - - - - k59_1575766_1 211114.JOEF01000001_gene7585 2.86e-18 77.0 COG0238@1|root,COG0238@2|Bacteria,2IQ92@201174|Actinobacteria,4E6ZN@85010|Pseudonocardiales 201174|Actinobacteria J Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit rpsR1 - - ko:K02963 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S18 k59_1575766_2 1007105.PT7_0468 4.48e-24 98.2 COG0359@1|root,COG0359@2|Bacteria,1RD0R@1224|Proteobacteria,2VR40@28216|Betaproteobacteria,3T3MM@506|Alcaligenaceae 28216|Betaproteobacteria J Binds to the 23S rRNA rplI - - ko:K02939 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L9_C,Ribosomal_L9_N k59_727393_1 767434.Fraau_2427 2.23e-86 261.0 COG0745@1|root,COG0745@2|Bacteria,1N0YI@1224|Proteobacteria,1RMWT@1236|Gammaproteobacteria,1X2XT@135614|Xanthomonadales 135614|Xanthomonadales KT Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain phoP - - ko:K07660 ko01503,ko02020,map01503,map02020 M00444,M00709,M00721,M00723,M00724,M00744 - - ko00000,ko00001,ko00002,ko01504,ko02022 - - - Response_reg,Trans_reg_C k59_727393_2 713586.KB900536_gene2283 7.09e-09 55.5 2913D@1|root,2ZNQV@2|Bacteria,1P4TF@1224|Proteobacteria,1SV4Y@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_948249_1 1175306.GWL_16170 4.5e-63 204.0 COG1043@1|root,COG1043@2|Bacteria,1MUHQ@1224|Proteobacteria,2VHDG@28216|Betaproteobacteria,472GR@75682|Oxalobacteraceae 28216|Betaproteobacteria M Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell lpxA - 2.3.1.129 ko:K00677 ko00540,ko01100,ko01503,map00540,map01100,map01503 M00060 R04567 RC00039,RC00055 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Acetyltransf_11,Hexapep k59_727400_1 316407.1742304 1.95e-106 338.0 COG1643@1|root,COG1643@2|Bacteria,1MUEQ@1224|Proteobacteria,1RMU1@1236|Gammaproteobacteria,3XN59@561|Escherichia 1236|Gammaproteobacteria L helicase HrpA hrpA GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0006139,GO:0006396,GO:0006397,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0034641,GO:0042623,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0070035,GO:0071704,GO:0090304,GO:0140098,GO:1901360 3.6.4.13 ko:K03578 - - - - ko00000,ko01000 - - - DEAD,DUF3418,HA2,Helicase_C,OB_NTP_bind k59_274339_1 1121380.JNIW01000017_gene3018 1.24e-32 128.0 COG1207@1|root,COG1207@2|Bacteria,1WIYX@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus M Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain glmU - 2.3.1.157,2.7.7.23 ko:K04042 ko00520,ko01100,ko01130,map00520,map01100,map01130 M00362 R00416,R05332 RC00002,RC00004,RC00166 ko00000,ko00001,ko00002,ko01000 - - - Hexapep,NTP_transf_3 k59_777621_1 391625.PPSIR1_27763 2.34e-45 159.0 COG1013@1|root,COG1013@2|Bacteria,1R5BF@1224|Proteobacteria,42MRV@68525|delta/epsilon subdivisions,2WK9C@28221|Deltaproteobacteria,2YZ1X@29|Myxococcales 28221|Deltaproteobacteria C PFAM thiamine pyrophosphate protein domain protein TPP-binding - - 1.2.7.11,1.2.7.3 ko:K00175 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - PFO_beta_C,TPP_enzyme_C k59_727406_1 1122165.AUHS01000003_gene2152 1.68e-36 134.0 COG1560@1|root,COG1560@2|Bacteria,1MVNI@1224|Proteobacteria,1SXQH@1236|Gammaproteobacteria,1JCPN@118969|Legionellales 118969|Legionellales M Bacterial lipid A biosynthesis acyltransferase - - 2.3.1.241 ko:K02517 ko00540,ko01100,map00540,map01100 M00060 R05146 RC00037,RC00039 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Lip_A_acyltrans k59_1456930_1 1122137.AQXF01000007_gene3498 3.58e-195 553.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2TQPG@28211|Alphaproteobacteria 28211|Alphaproteobacteria T COG2204 Response regulator containing CheY-like receiver AAA-type ATPase and DNA-binding domains - - - - - - - - - - - - HTH_8,Response_reg,Sigma54_activ_2,Sigma54_activat,V4R,XylR_N k59_1456930_2 1122137.AQXF01000007_gene3499 8.08e-33 125.0 COG5000@1|root,COG5000@2|Bacteria,1MWKZ@1224|Proteobacteria 1224|Proteobacteria T signal transduction histidine kinase - - 2.7.13.3 ko:K07709 ko02020,map02020 M00499 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA,PAS,PAS_8 k59_1518383_1 1453501.JELR01000002_gene341 6.93e-66 226.0 COG2885@1|root,COG2885@2|Bacteria,1QW22@1224|Proteobacteria,1T4AK@1236|Gammaproteobacteria,46ACU@72275|Alteromonadaceae 1236|Gammaproteobacteria M OmpA family - - - - - - - - - - - - DUF11,OmpA k59_727408_1 1122137.AQXF01000006_gene823 1.03e-07 60.5 COG0642@1|root,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria 1224|Proteobacteria T Histidine kinase - - 2.7.13.3 ko:K20974 ko02020,ko02025,map02020,map02025 M00820 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - CHASE,HATPase_c,HisKA,Hpt,PAS_3,Response_reg k59_551070_1 1123228.AUIH01000001_gene1191 4.53e-72 224.0 COG3571@1|root,COG3571@2|Bacteria,1RD20@1224|Proteobacteria,1S3Y4@1236|Gammaproteobacteria,1XK3I@135619|Oceanospirillales 135619|Oceanospirillales S hydrolase of the alpha beta-hydrolase fold - - - ko:K07020 - - - - ko00000 - - - Abhydrolase_5,Abhydrolase_6,DLH,Hydrolase_4 k59_1343458_1 926559.JoomaDRAFT_0386 1.84e-23 99.0 COG2273@1|root,COG4289@1|root,COG2273@2|Bacteria,COG4289@2|Bacteria,4NEU3@976|Bacteroidetes,1HZN1@117743|Flavobacteriia 976|Bacteroidetes G protein conserved in bacteria - - - - - - - - - - - - DUF2264,Glyco_hydro_16,Glyco_hydro_88 k59_1343458_2 1492738.FEM21_16580 9.65e-29 113.0 COG4225@1|root,COG4225@2|Bacteria,4NHM1@976|Bacteroidetes,1HY88@117743|Flavobacteriia,2NVCI@237|Flavobacterium 976|Bacteroidetes S BNR repeat-containing family member - - - - - - - - - - - - BNR_4 k59_1412465_1 1395513.P343_02890 2.8e-05 45.8 COG2201@1|root,COG2201@2|Bacteria,1TRHC@1239|Firmicutes,4HBJY@91061|Bacilli,26NQ8@186821|Sporolactobacillaceae 91061|Bacilli NT catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR cheB GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 3.1.1.61,3.5.1.44 ko:K03412 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko02022,ko02035 - - - CheB_methylest,Response_reg k59_1412465_2 1545915.JROG01000007_gene3269 1.31e-66 211.0 COG1352@1|root,COG1352@2|Bacteria,1MU6W@1224|Proteobacteria,2U1VY@28211|Alphaproteobacteria,2K2T1@204457|Sphingomonadales 204457|Sphingomonadales NT Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP - - 2.1.1.80 ko:K00575 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko01000,ko02035 - - - CheR,CheR_N k59_1016983_2 1502850.FG91_00559 6.49e-06 50.8 COG4774@1|root,COG4774@2|Bacteria,1NMCN@1224|Proteobacteria,2TW4E@28211|Alphaproteobacteria,2K2TV@204457|Sphingomonadales 204457|Sphingomonadales P TonB dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_282501_1 522306.CAP2UW1_0804 3.36e-67 220.0 COG0006@1|root,COG0006@2|Bacteria,1MUZS@1224|Proteobacteria,2VHQI@28216|Betaproteobacteria,1KPR2@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria E Belongs to the peptidase M24B family pepP - 3.4.11.9 ko:K01262 - - - - ko00000,ko01000,ko01002 - - - AMP_N,Peptidase_M24 k59_678001_1 196162.Noca_0170 5.59e-33 125.0 COG0077@1|root,COG0077@2|Bacteria,2GJQ5@201174|Actinobacteria,4DN8Z@85009|Propionibacteriales 201174|Actinobacteria E Prephenate dehydratase pheA - 1.3.1.12,4.2.1.51,5.4.99.5 ko:K04518,ko:K14170,ko:K14187 ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230 M00024,M00025 R00691,R01373,R01715,R01728 RC00125,RC00360,RC03116 ko00000,ko00001,ko00002,ko01000 - - - ACT,CM_2,PDT k59_1073488_1 1207076.ALAT01000011_gene1522 1.1e-83 256.0 COG0667@1|root,COG0667@2|Bacteria,1PDY4@1224|Proteobacteria,1RQYV@1236|Gammaproteobacteria,1Z16Z@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria C oxidoreductases (related to aryl-alcohol dehydrogenases) - - - - - - - - - - - - Aldo_ket_red k59_1638465_1 1415778.JQMM01000001_gene704 1.08e-86 267.0 COG0524@1|root,COG0524@2|Bacteria,1MUUC@1224|Proteobacteria,1RMN2@1236|Gammaproteobacteria,1J4GV@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria G COG0524 Sugar kinases, ribokinase family gsk GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008906,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0044237 2.7.1.15,2.7.1.4,2.7.1.73 ko:K00847,ko:K00852,ko:K00892 ko00030,ko00051,ko00230,ko00500,ko00520,ko01100,map00030,map00051,map00230,map00500,map00520,map01100 - R00760,R00867,R01051,R01131,R01228,R02750,R03920 RC00002,RC00017 ko00000,ko00001,ko01000 - - iSDY_1059.SDY_0442 PfkB k59_1242991_1 1223410.KN050846_gene418 3.98e-27 101.0 2AU0F@1|root,31JKB@2|Bacteria,4NHS6@976|Bacteroidetes,1I02M@117743|Flavobacteriia 976|Bacteroidetes S COG NOG14600 non supervised orthologous group - - - - - - - - - - - - - k59_565006_2 1122137.AQXF01000004_gene1835 1.19e-80 240.0 COG0494@1|root,COG0494@2|Bacteria,1RCZM@1224|Proteobacteria,2U7A4@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Belongs to the Nudix hydrolase family mutT GO:0003674,GO:0003824,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360 3.6.1.55 ko:K03574 - - - - ko00000,ko01000,ko03400 - - - Acetyltransf_3,NUDIX,NUDIX_4 k59_113014_1 575590.HMPREF0156_01116 1.52e-05 53.5 COG0507@1|root,COG0507@2|Bacteria,4NDYK@976|Bacteroidetes 976|Bacteroidetes L COG0507 ATP-dependent exoDNAse (exonuclease V) alpha subunit - helicase superfamily I member recD2_2 - 3.1.11.5 ko:K01144 - - - - ko00000,ko01000 - - - AAA_30,UvrD_C_2 k59_1468989_2 1279015.KB908457_gene2311 3.97e-56 185.0 COG0022@1|root,COG0022@2|Bacteria,1R8KB@1224|Proteobacteria,1RP3G@1236|Gammaproteobacteria,1Y56W@135624|Aeromonadales 135624|Aeromonadales C COG0022 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit - - 1.2.4.1,1.2.4.4 ko:K00162,ko:K00167 ko00010,ko00020,ko00280,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00280,map00620,map00640,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230 M00036,M00307 R00014,R00209,R01699,R03270,R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997 RC00004,RC00027,RC00627,RC02742,RC02743,RC02744,RC02882,RC02883,RC02949,RC02953 br01601,ko00000,ko00001,ko00002,ko01000 - - - Transket_pyr,Transketolase_C k59_1694980_1 278963.ATWD01000001_gene4385 2.55e-30 115.0 COG0581@1|root,COG0581@2|Bacteria,3Y3JF@57723|Acidobacteria,2JHVP@204432|Acidobacteriia 204432|Acidobacteriia P Phosphate transport system permease protein PstA - - - ko:K02038 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - BPD_transp_1 k59_1694980_2 1437606.BBOH_1555 7.76e-26 103.0 COG1117@1|root,COG1117@2|Bacteria,2GJQ3@201174|Actinobacteria,4CYVE@85004|Bifidobacteriales 201174|Actinobacteria P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system pstB - 3.6.3.27 ko:K02036 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.7 - - ABC_tran k59_904012_1 794846.AJQU01000045_gene4398 2.49e-102 298.0 COG0221@1|root,COG0221@2|Bacteria,1RA2F@1224|Proteobacteria,2TQZM@28211|Alphaproteobacteria,4BB0Q@82115|Rhizobiaceae 28211|Alphaproteobacteria C Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions ppa - 3.6.1.1 ko:K01507 ko00190,map00190 - - - ko00000,ko00001,ko01000 - - - Pyrophosphatase k59_904012_2 314260.PB2503_04942 2.51e-49 169.0 COG2133@1|root,COG2133@2|Bacteria,1MV2E@1224|Proteobacteria,2TR47@28211|Alphaproteobacteria 28211|Alphaproteobacteria G glucose sorbosone yliI - 1.1.5.2 ko:K00117,ko:K21430 ko00030,ko01100,ko01110,ko01130,map00030,map01100,map01110,map01130 - R06620 RC00066 ko00000,ko00001,ko01000 - - - GSDH k59_791016_1 1033736.CAHK01000049_gene1960 9.38e-20 93.6 COG0515@1|root,COG0515@2|Bacteria,2GJ1J@201174|Actinobacteria,4F8NT@85019|Brevibacteriaceae 201174|Actinobacteria KLT PASTA pknB GO:0000270,GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005623,GO:0006022,GO:0006023,GO:0006024,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008047,GO:0008150,GO:0008152,GO:0008360,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009605,GO:0009607,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0010698,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019216,GO:0019217,GO:0019222,GO:0019538,GO:0022603,GO:0022604,GO:0030145,GO:0030203,GO:0030234,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032091,GO:0034645,GO:0036211,GO:0040007,GO:0042304,GO:0042546,GO:0042802,GO:0043085,GO:0043086,GO:0043167,GO:0043169,GO:0043170,GO:0043207,GO:0043388,GO:0043393,GO:0043412,GO:0044036,GO:0044038,GO:0044085,GO:0044092,GO:0044093,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044403,GO:0044419,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046777,GO:0046872,GO:0046890,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050793,GO:0050794,GO:0050896,GO:0051055,GO:0051098,GO:0051099,GO:0051100,GO:0051101,GO:0051128,GO:0051701,GO:0051704,GO:0051707,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0062012,GO:0062014,GO:0065007,GO:0065008,GO:0065009,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:0075136,GO:0080090,GO:0098772,GO:0140096,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 2.7.11.1 ko:K08884,ko:K12132 - - - - ko00000,ko01000,ko01001 - - - PASTA,Pkinase k59_113027_1 1366050.N234_19250 3.29e-104 336.0 COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,1MU7B@1224|Proteobacteria,2VHUY@28216|Betaproteobacteria,1K0VQ@119060|Burkholderiaceae 28216|Betaproteobacteria E glutamate synthase gltB - 1.4.1.13,1.4.1.14,1.4.7.1 ko:K00265,ko:K00284 ko00250,ko00630,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00630,map00910,map01100,map01110,map01120,map01130,map01230 - R00021,R00093,R00114,R00248,R10086 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - GATase_2,GXGXG,Glu_syn_central,Glu_synthase k59_1243005_1 509635.N824_01340 9.62e-47 163.0 COG3507@1|root,COG3507@2|Bacteria,4NGA5@976|Bacteroidetes,1IP09@117747|Sphingobacteriia 976|Bacteroidetes G Belongs to the glycosyl hydrolase 43 family - - - - - - - - - - - - Glyco_hydro_43 k59_56542_1 158500.BV97_00995 1.37e-108 335.0 COG0784@1|root,COG4191@1|root,COG0784@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TQQ9@28211|Alphaproteobacteria,2K0WG@204457|Sphingomonadales 204457|Sphingomonadales T Histidine kinase - - 2.7.13.3 ko:K13587 ko02020,ko04112,map02020,map04112 M00512 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA,PAS_4,PAS_8,Response_reg k59_1243006_1 1134474.O59_003724 1.58e-70 223.0 COG0030@1|root,COG0030@2|Bacteria,1MVNU@1224|Proteobacteria,1RMHW@1236|Gammaproteobacteria,1FGA8@10|Cellvibrio 1236|Gammaproteobacteria J Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits ksgA GO:0000028,GO:0000154,GO:0000179,GO:0001510,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003723,GO:0003729,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016072,GO:0016433,GO:0016740,GO:0016741,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0031167,GO:0032259,GO:0034470,GO:0034622,GO:0034641,GO:0034660,GO:0042254,GO:0042255,GO:0042274,GO:0043170,GO:0043412,GO:0043414,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0065003,GO:0070475,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0097159,GO:0140098,GO:0140102,GO:1901360,GO:1901363 2.1.1.182 ko:K02528 - - R10716 RC00003,RC03257 ko00000,ko01000,ko03009 - - - RrnaAD k59_1186493_1 258533.BN977_00180 3.14e-52 181.0 COG0318@1|root,COG0318@2|Bacteria,2GJA2@201174|Actinobacteria,232FY@1762|Mycobacteriaceae 201174|Actinobacteria IQ COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II - - - ko:K00666 - - - - ko00000,ko01000,ko01004 - - - AMP-binding,AMP-binding_C k59_1469000_1 1122137.AQXF01000007_gene3625 3.26e-87 271.0 COG2224@1|root,COG2224@2|Bacteria,1MWIF@1224|Proteobacteria,2TU0Q@28211|Alphaproteobacteria 28211|Alphaproteobacteria C Isocitrate lyase aceA - 4.1.3.1 ko:K01637 ko00630,ko01100,ko01110,ko01120,ko01200,map00630,map01100,map01110,map01120,map01200 M00012 R00479 RC00311,RC00313 ko00000,ko00001,ko00002,ko01000 - - - ICL k59_1469000_2 1123060.JONP01000004_gene527 4.48e-17 76.3 COG2314@1|root,COG2314@2|Bacteria,1N8Y8@1224|Proteobacteria,2UFKT@28211|Alphaproteobacteria 28211|Alphaproteobacteria S TM2 domain - - - - - - - - - - - - TM2 k59_904022_1 157783.LK03_17485 4.02e-20 94.4 COG0729@1|root,COG0729@2|Bacteria,1MUKM@1224|Proteobacteria,1RNQ3@1236|Gammaproteobacteria 1236|Gammaproteobacteria M COG0729 Outer membrane protein ytfM GO:0002790,GO:0005575,GO:0005623,GO:0006810,GO:0008104,GO:0008150,GO:0009279,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0019867,GO:0030312,GO:0030313,GO:0031224,GO:0031230,GO:0031975,GO:0032940,GO:0032991,GO:0033036,GO:0042886,GO:0044425,GO:0044462,GO:0044464,GO:0045184,GO:0045203,GO:0046903,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944,GO:0097347 - ko:K07278 - - - - ko00000,ko02000 1.B.33.2.4 - - Bac_surface_Ag,POTRA,POTRA_TamA_1 k59_1130020_1 1549858.MC45_00945 1.69e-124 362.0 COG0384@1|root,COG0384@2|Bacteria,1MUAS@1224|Proteobacteria,2U3ND@28211|Alphaproteobacteria,2KD9U@204457|Sphingomonadales 204457|Sphingomonadales S phenazine biosynthesis protein - - - - - - - - - - - - PhzC-PhzF k59_1130020_2 1170562.Cal6303_2669 8.41e-26 104.0 COG0454@1|root,COG0454@2|Bacteria,1G5K5@1117|Cyanobacteria,1HMPM@1161|Nostocales 1117|Cyanobacteria K Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_1 k59_169550_1 980584.AFPB01000178_gene710 1.99e-16 74.7 COG0244@1|root,COG0244@2|Bacteria,4NFFK@976|Bacteroidetes,1HXJG@117743|Flavobacteriia,406CY@61432|unclassified Flavobacteriaceae 976|Bacteroidetes J Ribosomal protein L10 rplJ - - ko:K02864 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L10 k59_169550_2 1197477.IA57_01550 1.39e-64 202.0 COG0081@1|root,COG0081@2|Bacteria,4NEIC@976|Bacteroidetes,1HZJ6@117743|Flavobacteriia 976|Bacteroidetes J Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release rplA GO:0000470,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022625,GO:0022626,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02863 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L1 k59_1299533_2 877415.JNJQ01000002_gene2405 1.46e-14 73.2 COG0598@1|root,COG0598@2|Bacteria,1TPSV@1239|Firmicutes,3VQWA@526524|Erysipelotrichia 526524|Erysipelotrichia P CorA-like Mg2+ transporter protein - - - - - - - - - - - - CorA k59_508563_1 436308.Nmar_1652 1.67e-55 195.0 COG4257@1|root,arCOG06267@1|root,arCOG03564@2157|Archaea,arCOG06267@2157|Archaea,41S5S@651137|Thaumarchaeota 651137|Thaumarchaeota V resistance protein - - - ko:K14166 - - - - ko00000,ko02000 - - - CopC,CopD k59_1299538_1 1167006.UWK_03571 2.01e-75 239.0 COG1007@1|root,COG1007@2|Bacteria,1MV56@1224|Proteobacteria,42P7Z@68525|delta/epsilon subdivisions,2WKS0@28221|Deltaproteobacteria,2MIJK@213118|Desulfobacterales 28221|Deltaproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoN - 1.6.5.3 ko:K00343 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Proton_antipo_M k59_565054_1 1248917.ANFX01000012_gene1788 1.35e-95 292.0 COG3391@1|root,COG3391@2|Bacteria,1MXXH@1224|Proteobacteria,2TW31@28211|Alphaproteobacteria,2K2PG@204457|Sphingomonadales 204457|Sphingomonadales S Cytochrome c554 and c-prime - - - - - - - - - - - - Cytochrome_C554 k59_1017064_1 1341181.FLJC2902T_00460 1.32e-91 279.0 COG2873@1|root,COG2873@2|Bacteria,4NE27@976|Bacteroidetes,1HXJC@117743|Flavobacteriia,2NSFM@237|Flavobacterium 976|Bacteroidetes E Catalyzes the formation of L-homocysteine from O- succinyl-L-homoserine (OSHS) and hydrogen sulfide metZ - 2.5.1.49 ko:K01740,ko:K10764 ko00270,ko00920,ko01100,map00270,map00920,map01100 - R01287,R01288,R04859 RC00020,RC02821,RC02848 ko00000,ko00001,ko01000 - - - Cys_Met_Meta_PP k59_1638513_1 998674.ATTE01000001_gene3907 1.03e-127 369.0 COG0410@1|root,COG0410@2|Bacteria,1MVVC@1224|Proteobacteria,1RMK8@1236|Gammaproteobacteria 1236|Gammaproteobacteria P Branched-chain amino acid transport livF3 - - ko:K01996 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - ABC_tran k59_1638513_2 1449350.OCH239_07490 1.04e-05 47.0 COG1541@1|root,COG1541@2|Bacteria,1MV1W@1224|Proteobacteria,2TQN5@28211|Alphaproteobacteria,4KM4Y@93682|Roseivivax 28211|Alphaproteobacteria H COG1541 Coenzyme F390 synthetase paaK - 6.2.1.30 ko:K01912 ko00360,ko01120,ko05111,map00360,map01120,map05111 - R02539 RC00004,RC00014 ko00000,ko00001,ko01000 - - - AMP-binding,AMP-binding_C_2 k59_1751516_1 316407.85676075 2.6e-177 508.0 COG0422@1|root,COG0422@2|Bacteria,1MUVV@1224|Proteobacteria,1RP1F@1236|Gammaproteobacteria,3XMHV@561|Escherichia 1236|Gammaproteobacteria H Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction thiC GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.99.17 ko:K03147 ko00730,ko01100,map00730,map01100 M00127 R03472 RC03251,RC03252 ko00000,ko00001,ko00002,ko01000 - - iECABU_c1320.ECABU_c45100 ThiC-associated,ThiC_Rad_SAM k59_1017068_1 267608.RSc0395 1.6e-67 213.0 COG0462@1|root,COG0462@2|Bacteria,1MW21@1224|Proteobacteria,2VHU0@28216|Betaproteobacteria,1K1FD@119060|Burkholderiaceae 28216|Betaproteobacteria F Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) prs - 2.7.6.1 ko:K00948 ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230 M00005 R01049 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - Pribosyl_synth,Pribosyltran_N k59_1130059_1 748247.AZKH_4207 3.61e-19 91.3 COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,2VHEM@28216|Betaproteobacteria,2KY2G@206389|Rhodocyclales 206389|Rhodocyclales O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins - - - ko:K03798 - M00742 - - ko00000,ko00002,ko01000,ko01002,ko03110 - - - AAA,FtsH_ext,Peptidase_M41 k59_89_1 477228.YO5_03907 5.09e-42 147.0 COG0275@1|root,COG0275@2|Bacteria,1MUT4@1224|Proteobacteria,1RM7M@1236|Gammaproteobacteria,1Z2ED@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria J Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA rsmH GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070475,GO:0071424,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.199 ko:K03438 - - - - ko00000,ko01000,ko03009 - - - Methyltransf_5 k59_89_2 323848.Nmul_A2501 2.08e-12 65.1 COG3116@1|root,COG3116@2|Bacteria,1N6WK@1224|Proteobacteria,2VW1W@28216|Betaproteobacteria,373NV@32003|Nitrosomonadales 28216|Betaproteobacteria D Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic ftsL - - ko:K03586 - - - - ko00000,ko03036 - - - FtsL k59_1412526_1 78245.Xaut_2335 4.64e-34 133.0 COG4251@1|root,COG5278@1|root,COG4251@2|Bacteria,COG5278@2|Bacteria,1NSQ1@1224|Proteobacteria,2TSPY@28211|Alphaproteobacteria,3F09D@335928|Xanthobacteraceae 28211|Alphaproteobacteria T CHASE3 domain - - - - - - - - - - - - CHASE3,HATPase_c,HisKA,MHYT,PAS_3 k59_1751518_1 1122137.AQXF01000006_gene736 2.55e-197 566.0 COG4805@1|root,COG4805@2|Bacteria,1MUBX@1224|Proteobacteria,2TSUQ@28211|Alphaproteobacteria 28211|Alphaproteobacteria O Protein conserved in bacteria - - - - - - - - - - - - DUF885 k59_113094_1 926562.Oweho_1267 2.61e-24 107.0 COG0457@1|root,COG3379@1|root,COG0457@2|Bacteria,COG3379@2|Bacteria 2|Bacteria S Type I phosphodiesterase / nucleotide pyrophosphatase - - - - - - - - - - - - Phosphodiest,Sulfotransfer_1,TPR_16,TPR_19 k59_1525547_1 196367.JNFG01000215_gene783 9.2e-84 262.0 COG2271@1|root,COG2271@2|Bacteria,1MVPS@1224|Proteobacteria,2VKBG@28216|Betaproteobacteria,1K17S@119060|Burkholderiaceae 28216|Betaproteobacteria G Major facilitator superfamily MFS_1 - - - ko:K08194 - - - - ko00000,ko02000 2.A.1.14.7 - - MFS_1 k59_452073_1 751994.AGIG01000028_gene2025 3.07e-25 108.0 COG0789@1|root,COG5012@1|root,COG0789@2|Bacteria,COG5012@2|Bacteria,1R2NF@1224|Proteobacteria 1224|Proteobacteria K PFAM regulatory protein, MerR - - - ko:K22491 - - - - ko00000,ko03000 - - - B12-binding,B12-binding_2,MerR_1 k59_226063_1 1046627.BZARG_648 1.78e-94 281.0 COG0119@1|root,COG0119@2|Bacteria,4NDZH@976|Bacteroidetes,1HWWP@117743|Flavobacteriia 976|Bacteroidetes E Hydroxymethylglutaryl-CoA lyase mvaB - 4.1.3.4 ko:K01640 ko00072,ko00280,ko00281,ko00650,ko01100,ko04146,map00072,map00280,map00281,map00650,map01100,map04146 M00036,M00088 R01360,R08090 RC00502,RC00503,RC01118,RC01946 ko00000,ko00001,ko00002,ko01000 - - - HMGL-like k59_226063_2 391603.FBALC1_10567 4.89e-16 75.9 2BVHW@1|root,32QW8@2|Bacteria,4NQ2Q@976|Bacteroidetes,1I316@117743|Flavobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_282591_1 436308.Nmar_1784 1.29e-27 101.0 arCOG08810@1|root,arCOG08810@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_1073549_1 497964.CfE428DRAFT_2490 3.62e-08 57.8 COG0497@1|root,COG0497@2|Bacteria,46SGB@74201|Verrucomicrobia 74201|Verrucomicrobia L May be involved in recombinational repair of damaged DNA recN - - ko:K03631 - - - - ko00000,ko03400 - - - SMC_N k59_169586_1 1235813.JCM10003_3191 3.33e-16 77.8 COG1091@1|root,COG1091@2|Bacteria,4NE3K@976|Bacteroidetes,2FN7H@200643|Bacteroidia,4AMIY@815|Bacteroidaceae 976|Bacteroidetes M Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose rfbD - 1.1.1.133 ko:K00067 ko00521,ko00523,ko01130,map00521,map00523,map01130 M00793 R02777 RC00182 ko00000,ko00001,ko00002,ko01000 - - - RmlD_sub_bind k59_1751531_1 1096546.WYO_3593 3.24e-10 59.7 COG2303@1|root,COG2303@2|Bacteria,1MUK2@1224|Proteobacteria,2U08V@28211|Alphaproteobacteria,1JTFM@119045|Methylobacteriaceae 28211|Alphaproteobacteria E PFAM glucose-methanol-choline oxidoreductase - - - - - - - - - - - - FAD_binding_2,GMC_oxred_C,GMC_oxred_N,NAD_binding_8 k59_1130082_1 582744.Msip34_1771 2.18e-24 115.0 COG1629@1|root,COG1629@2|Bacteria,1QTVF@1224|Proteobacteria,2VMVG@28216|Betaproteobacteria,2KKX3@206350|Nitrosomonadales 206350|Nitrosomonadales P TonB dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_1582051_1 395493.BegalDRAFT_0037 4.32e-66 213.0 COG2304@1|root,COG2304@2|Bacteria,1MXQ7@1224|Proteobacteria,1RMDX@1236|Gammaproteobacteria,4604T@72273|Thiotrichales 72273|Thiotrichales S von Willebrand factor, type A - - - ko:K07114 - - - - ko00000,ko02000 1.A.13.2.2,1.A.13.2.3 - - VWA,VWA_2 k59_113113_2 1229909.NSED_01470 7.49e-60 186.0 arCOG08781@1|root,arCOG08781@2157|Archaea,41SVY@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1243058_1 95619.PM1_0216555 1.22e-55 182.0 COG4137@1|root,COG4137@2|Bacteria,1R3YD@1224|Proteobacteria,1RPUQ@1236|Gammaproteobacteria 1236|Gammaproteobacteria S cytochrome C assembly protein ypjD GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - - - - - - - - - - Cytochrom_C_asm k59_960585_1 314345.SPV1_01092 5.34e-15 73.2 COG2020@1|root,COG2020@2|Bacteria 2|Bacteria O methyltransferase activity - - - - - - - - - - - - PEMT k59_621589_1 641143.HMPREF9331_02152 1.58e-48 168.0 COG0372@1|root,COG0372@2|Bacteria,4NFXK@976|Bacteroidetes,1HWVX@117743|Flavobacteriia,1ER19@1016|Capnocytophaga 976|Bacteroidetes H citrate synthase gltA - 2.3.3.1 ko:K01647 ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00740 R00351 RC00004,RC00067 br01601,ko00000,ko00001,ko00002,ko01000 - - - Citrate_synt k59_1299599_1 911045.PSE_3737 4.33e-23 103.0 COG1289@1|root,COG1289@2|Bacteria 2|Bacteria S transmembrane transporter activity VPA1578 - - - - - - - - - - - FUSC k59_282640_1 1461694.ATO9_20940 0.000462 47.8 COG1377@1|root,COG1377@2|Bacteria,1MUWI@1224|Proteobacteria,2TS13@28211|Alphaproteobacteria,2PF9D@252301|Oceanicola 28211|Alphaproteobacteria N FlhB HrpN YscU SpaS Family flhB - - ko:K02401 ko02040,map02040 - - - ko00000,ko00001,ko02035,ko02044 3.A.6.2 - - Bac_export_2 k59_1186578_1 717773.Thicy_1397 4.43e-12 67.8 COG0525@1|root,COG0525@2|Bacteria,1MV7B@1224|Proteobacteria,1RNEB@1236|Gammaproteobacteria,45ZRC@72273|Thiotrichales 72273|Thiotrichales J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner valS - 6.1.1.9 ko:K01873 ko00970,map00970 M00359,M00360 R03665 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1 k59_1186578_2 390235.PputW619_1722 4.66e-28 108.0 COG0730@1|root,COG0730@2|Bacteria,1MWX2@1224|Proteobacteria,1S2BC@1236|Gammaproteobacteria,1YXBN@136845|Pseudomonas putida group 1236|Gammaproteobacteria S membrane transporter protein - - - ko:K07090 - - - - ko00000 - - - TauE k59_1751554_1 1415778.JQMM01000001_gene397 9.45e-189 565.0 COG0086@1|root,COG0086@2|Bacteria,1MU3M@1224|Proteobacteria,1RPYH@1236|Gammaproteobacteria,1J4ZQ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoC GO:0000428,GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0030880,GO:0032774,GO:0032991,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234 2.7.7.6 ko:K03046 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5 k59_154_1 158500.BV97_02043 1.92e-108 317.0 COG0623@1|root,COG0623@2|Bacteria,1MV05@1224|Proteobacteria,2TSU4@28211|Alphaproteobacteria,2K0BH@204457|Sphingomonadales 204457|Sphingomonadales I Enoyl- acyl-carrier-protein reductase NADH fabI - 1.3.1.10,1.3.1.9 ko:K00208 ko00061,ko00333,ko00780,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01100,map01130,map01212 M00083,M00572 R01404,R04429,R04430,R04724,R04725,R04955,R04956,R04958,R04959,R04961,R04962,R04966,R04967,R04969,R04970,R07765,R10118,R10122,R11671 RC00052,RC00076,RC00120 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 k59_169644_1 472759.Nhal_1189 5.25e-45 165.0 COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,1RMYC@1236|Gammaproteobacteria,1WX32@135613|Chromatiales 135613|Chromatiales P ATPase, P-type (transporting), HAD superfamily, subfamily IC - - 3.6.3.8 ko:K01537 - - - - ko00000,ko01000 3.A.3.2 - - Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3 k59_904116_1 314285.KT71_01825 1.26e-75 249.0 COG1262@1|root,COG1262@2|Bacteria,1NQ5K@1224|Proteobacteria,1RQVS@1236|Gammaproteobacteria,1J55S@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Sulfatase-modifying factor enzyme 1 - - - - - - - - - - - - FGE-sulfatase,PEGA k59_1525612_1 1535422.ND16A_1041 2.92e-103 320.0 COG1297@1|root,COG1297@2|Bacteria,1N7SK@1224|Proteobacteria,1RNC8@1236|Gammaproteobacteria 1236|Gammaproteobacteria S oligopeptide transporter oliA GO:0003674,GO:0005215,GO:0005575,GO:0006810,GO:0008150,GO:0016020,GO:0022857,GO:0051179,GO:0051234,GO:0055085 - - - - - - - - - - OPT k59_508644_1 247634.GPB2148_158 2.52e-50 173.0 COG0008@1|root,COG0008@2|Bacteria,1MUCR@1224|Proteobacteria,1RN3R@1236|Gammaproteobacteria,1J547@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) gltX GO:0003674,GO:0003824,GO:0004812,GO:0004818,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006424,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.17 ko:K01885 ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120 M00121,M00359,M00360 R05578 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016 - - iEC042_1314.EC042_2616 tRNA-synt_1c k59_508644_2 1122604.JONR01000007_gene2878 7.11e-39 139.0 COG0625@1|root,COG0625@2|Bacteria,1R7YC@1224|Proteobacteria,1S06X@1236|Gammaproteobacteria,1X693@135614|Xanthomonadales 135614|Xanthomonadales O Glutathione S-transferase, N-terminal domain - - - - - - - - - - - - GST_N_3 k59_734646_1 436308.Nmar_1770 1.65e-09 57.4 arCOG08811@1|root,arCOG08811@2157|Archaea,41T85@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1412596_2 270374.MELB17_00095 1.4e-10 61.2 COG0129@1|root,COG0129@2|Bacteria,1MUTQ@1224|Proteobacteria,1RMP2@1236|Gammaproteobacteria,4664R@72275|Alteromonadaceae 1236|Gammaproteobacteria EG Belongs to the IlvD Edd family ilvD - 4.2.1.9 ko:K01687 ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R01209,R04441,R05070 RC00468,RC01714 ko00000,ko00001,ko00002,ko01000 - - - ILVD_EDD k59_904117_1 316407.85675701 4.48e-134 379.0 COG1443@1|root,COG1443@2|Bacteria,1R9YJ@1224|Proteobacteria,1S6ZT@1236|Gammaproteobacteria,3XNXM@561|Escherichia 1236|Gammaproteobacteria I Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) idi GO:0003674,GO:0003824,GO:0004452,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006629,GO:0006644,GO:0006720,GO:0006793,GO:0006796,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016853,GO:0016860,GO:0016863,GO:0019637,GO:0033554,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044464,GO:0046490,GO:0050896,GO:0051716,GO:0071704,GO:0090407,GO:1901576 4.1.1.33,5.3.3.2 ko:K01597,ko:K01823 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00095,M00096,M00364,M00365,M00366,M00367 R01121,R01123 RC00453,RC00455 ko00000,ko00001,ko00002,ko01000 - - iECH74115_1262.ECH74115_4179,iECIAI1_1343.ECIAI1_3008,iECO103_1326.ECO103_3464,iECSP_1301.ECSP_3858,iECs_1301.ECs3761,iEcE24377_1341.EcE24377A_3215,iG2583_1286.G2583_3542,iSFV_1184.SFV_2937,iSF_1195.SF2875,iSFxv_1172.SFxv_3153,iSSON_1240.SSON_3042,iS_1188.S3074,iZ_1308.Z4227 NUDIX k59_1638582_1 384765.SIAM614_09733 3.3e-70 221.0 COG3618@1|root,COG3618@2|Bacteria,1P5PT@1224|Proteobacteria,2U3BR@28211|Alphaproteobacteria 28211|Alphaproteobacteria S metal-dependent hydrolase of the TIM-barrel fold - - - ko:K07046 ko00051,ko01120,map00051,map01120 - R10689 RC00537 ko00000,ko00001,ko01000 - - - Amidohydro_2 k59_791139_1 1463825.JNXC01000003_gene3750 3.51e-26 113.0 COG1196@1|root,COG1196@2|Bacteria,2GK93@201174|Actinobacteria,4DYMX@85010|Pseudonocardiales 201174|Actinobacteria D Required for chromosome condensation and partitioning smc GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944 - ko:K03529 - - - - ko00000,ko03036 - - - SMC_N,SMC_hinge k59_1300873_1 1144305.PMI02_01235 8.17e-68 211.0 COG3719@1|root,COG3719@2|Bacteria,1PTUN@1224|Proteobacteria,2TQUU@28211|Alphaproteobacteria,2K2KG@204457|Sphingomonadales 204457|Sphingomonadales J Belongs to the RNase T2 family - - 3.1.27.1 ko:K01166 - - - - ko00000,ko01000,ko03016 - - - Ribonuclease_T2 k59_340340_1 1121949.AQXT01000002_gene3005 6.54e-28 116.0 COG1228@1|root,COG1228@2|Bacteria,1MY4V@1224|Proteobacteria,2U3IV@28211|Alphaproteobacteria,43X0R@69657|Hyphomonadaceae 28211|Alphaproteobacteria Q COG1228 Imidazolonepropionase and related amidohydrolases - - - - - - - - - - - - Amidohydro_1 k59_1421218_1 1545915.JROG01000009_gene2664 4.31e-32 136.0 COG1629@1|root,COG4771@2|Bacteria,1MWKN@1224|Proteobacteria,2U3YD@28211|Alphaproteobacteria,2KEF9@204457|Sphingomonadales 204457|Sphingomonadales P TonB-dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_630516_1 1120953.AUBH01000001_gene1201 6.57e-78 254.0 COG1501@1|root,COG1501@2|Bacteria,1MWNJ@1224|Proteobacteria,1RMJ9@1236|Gammaproteobacteria,465UA@72275|Alteromonadaceae 1236|Gammaproteobacteria G Belongs to the glycosyl hydrolase 31 family malZ GO:0003674,GO:0003824,GO:0016740,GO:0016757,GO:0016758,GO:0033825,GO:0046527 2.4.1.161,3.2.1.177,3.2.1.20 ko:K01187,ko:K01811,ko:K18820 ko00052,ko00500,ko01100,map00052,map00500,map01100 - R00028,R00801,R00802,R06087,R06088 RC00028,RC00049,RC00077 ko00000,ko00001,ko01000 - GH31 - CBM_20,DUF4968,DUF5110,Gal_mutarotas_2,Glyco_hydro_31,PA14 k59_461109_2 522306.CAP2UW1_0384 3.23e-49 176.0 COG2885@1|root,COG3808@1|root,COG2885@2|Bacteria,COG3808@2|Bacteria,1MUQ3@1224|Proteobacteria,2VI3K@28216|Betaproteobacteria,1KQ7I@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria C Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force hppA - 3.6.1.1 ko:K15987 ko00190,map00190 - - - ko00000,ko00001,ko01000 3.A.10.1 - - H_PPase,OmpA k59_1647814_1 768671.ThimaDRAFT_1461 5.8e-48 159.0 COG0745@1|root,COG0745@2|Bacteria,1MU3A@1224|Proteobacteria,1RRT6@1236|Gammaproteobacteria,1WXWX@135613|Chromatiales 135613|Chromatiales K response regulator receiver - - - ko:K07776 ko02020,map02020 M00443 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Trans_reg_C k59_1647814_2 349521.HCH_00945 1.65e-22 93.2 COG1842@1|root,COG1842@2|Bacteria 2|Bacteria KT Phage shock protein A - - - ko:K03969 - - - - ko00000 - - - PspA_IM30 k59_1138911_1 1121013.P873_01910 1.18e-17 83.6 COG1663@1|root,COG1663@2|Bacteria,1MU8G@1224|Proteobacteria,1RMMW@1236|Gammaproteobacteria,1X3DM@135614|Xanthomonadales 135614|Xanthomonadales M Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) lpxK - 2.7.1.130 ko:K00912 ko00540,ko01100,map00540,map01100 M00060 R04657 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000,ko01005 - - - LpxK k59_1138911_2 580332.Slit_1363 7.05e-23 89.0 COG2835@1|root,COG2835@2|Bacteria,1N6Y2@1224|Proteobacteria,2VW58@28216|Betaproteobacteria,44W2Q@713636|Nitrosomonadales 28216|Betaproteobacteria S Trm112p-like protein ycaR - - ko:K09791 - - - - ko00000 - - - Trm112p k59_1138911_3 34506.g6122 8.9e-09 55.8 COG1663@1|root,2RUHI@2759|Eukaryota,39HZU@33154|Opisthokonta,3CMT8@33208|Metazoa,3E3F2@33213|Bilateria,40PU3@6231|Nematoda,1M7BC@119089|Chromadorea,415XZ@6236|Rhabditida 33208|Metazoa M Tetraacyldisaccharide-1-P 4'-kinase - - - - - - - - - - - - LpxK k59_1026883_1 498211.CJA_1772 3.12e-81 254.0 COG1249@1|root,COG1249@2|Bacteria,1MVVE@1224|Proteobacteria,1RMJT@1236|Gammaproteobacteria,1FGXF@10|Cellvibrio 1236|Gammaproteobacteria C FAD dependent oxidoreductase sthA GO:0000166,GO:0003674,GO:0003824,GO:0003957,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0008746,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015672,GO:0016491,GO:0016651,GO:0016652,GO:0019725,GO:0022857,GO:0022890,GO:0034220,GO:0036094,GO:0042592,GO:0042802,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0045454,GO:0048037,GO:0050660,GO:0050662,GO:0050789,GO:0050794,GO:0051179,GO:0051234,GO:0055085,GO:0055114,GO:0065007,GO:0065008,GO:0097159,GO:0098655,GO:0098660,GO:0098662,GO:1901265,GO:1901363,GO:1902600 1.6.1.1 ko:K00322 ko00760,ko01100,map00760,map01100 - R00112 RC00001 ko00000,ko00001,ko01000 - - iECED1_1282.ECED1_4669,iECs_1301.ECs4891,iZ_1308.Z5521 Pyr_redox_2,Pyr_redox_dim k59_1647820_1 1380387.JADM01000016_gene3825 6.53e-56 188.0 COG1301@1|root,COG1301@2|Bacteria,1MU0Q@1224|Proteobacteria,1RMEN@1236|Gammaproteobacteria,1XHZY@135619|Oceanospirillales 135619|Oceanospirillales U Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family gltP - - - - - - - - - - - SDF k59_1703860_1 745411.B3C1_00710 4.26e-63 213.0 COG0616@1|root,COG0616@2|Bacteria,1MUXE@1224|Proteobacteria,1RNYW@1236|Gammaproteobacteria,1J4TN@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria OU COG0616 Periplasmic serine proteases (ClpP class) sppA GO:0003674,GO:0003824,GO:0004175,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006465,GO:0006508,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009987,GO:0010467,GO:0016020,GO:0016021,GO:0016485,GO:0016787,GO:0019538,GO:0031224,GO:0031226,GO:0034641,GO:0043170,GO:0043603,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0051604,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564 - ko:K04773 - - - - ko00000,ko01000,ko01002 - - - Peptidase_S49 k59_461121_1 1125863.JAFN01000001_gene2260 3.85e-23 98.6 COG3420@1|root,COG3420@2|Bacteria,1Q48B@1224|Proteobacteria,42YK2@68525|delta/epsilon subdivisions,2WUN5@28221|Deltaproteobacteria 28221|Deltaproteobacteria P PQQ-like domain - - - - - - - - - - - - PQQ_3 k59_687014_1 436308.Nmar_0658 3.85e-143 417.0 COG0008@1|root,arCOG00402@2157|Archaea,41SFI@651137|Thaumarchaeota 651137|Thaumarchaeota J Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) proS - 6.1.1.15 ko:K01881 ko00970,map00970 M00359,M00360 R03661 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,ProRS-C_1,tRNA-synt_2b k59_913221_1 1122134.KB893650_gene1381 3.49e-127 377.0 COG0644@1|root,COG2440@1|root,COG0644@2|Bacteria,COG2440@2|Bacteria,1MVU6@1224|Proteobacteria,1RNY5@1236|Gammaproteobacteria,1XHVH@135619|Oceanospirillales 135619|Oceanospirillales C Electron transfer flavoprotein-ubiquinone oxidoreductase etf - 1.5.5.1 ko:K00311 - - - - ko00000,ko01000 - - - ETF_QO,FAD_binding_2,NAD_binding_8 k59_1760511_1 1161401.ASJA01000001_gene377 9.55e-26 100.0 COG4067@1|root,COG4067@2|Bacteria,1QXY3@1224|Proteobacteria,2TYFX@28211|Alphaproteobacteria,4415C@69657|Hyphomonadaceae 28211|Alphaproteobacteria O Putative ATP-dependant zinc protease - - - - - - - - - - - - Zn_protease k59_178626_1 1229909.NSED_01680 3.49e-29 105.0 COG1958@1|root,arCOG00998@2157|Archaea 2157|Archaea K Like-Sm ribonucleoprotein core lsm GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360 - ko:K04796 - - - - ko00000 - - - LSM k59_178626_2 436308.Nmar_0348 2.98e-48 171.0 COG0086@1|root,arCOG04256@2157|Archaea,arCOG04257@2157|Archaea,41SB2@651137|Thaumarchaeota 651137|Thaumarchaeota K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoA2 - 2.7.7.6 ko:K03041 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00184 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021 - - - RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5 k59_1421257_1 880072.Desac_2171 2.89e-49 177.0 COG0417@1|root,COG0417@2|Bacteria 2|Bacteria L DNA replication proofreading polB - 2.7.7.7 ko:K02336,ko:K06877 - - - - ko00000,ko01000,ko03400 - - - CarbopepD_reg_2,DNA_pol_B,DNA_pol_B_exo1,RNase_H_2 k59_292310_1 436308.Nmar_0594 9.76e-71 225.0 COG0265@1|root,arCOG02833@2157|Archaea,41S9W@651137|Thaumarchaeota 651137|Thaumarchaeota O Trypsin-like serine protease with C-terminal PDZ domain - - - - - - - - - - - - PDZ_2,Trypsin_2 k59_969356_1 1004149.AFOE01000006_gene2002 5.96e-39 137.0 COG1159@1|root,COG1159@2|Bacteria,4NES2@976|Bacteroidetes,1HX06@117743|Flavobacteriia 976|Bacteroidetes S An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism era - - ko:K03595 - - - - ko00000,ko03009,ko03029 - - - KH_2,MMR_HSR1 k59_969356_2 1123037.AUDE01000029_gene1532 6.51e-46 152.0 299NP@1|root,2ZWR1@2|Bacteria,4NP8Q@976|Bacteroidetes,1I269@117743|Flavobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_687031_2 698964.CDPW8_0947 2.05e-07 52.8 COG1611@1|root,COG1611@2|Bacteria,2GKJH@201174|Actinobacteria,22JX4@1653|Corynebacteriaceae 201174|Actinobacteria S Belongs to the LOG family fmt2 - 3.2.2.10 ko:K06966 ko00230,ko00240,map00230,map00240 - R00182,R00510 RC00063,RC00318 ko00000,ko00001,ko01000 - - - Lysine_decarbox k59_348670_1 743722.Sph21_1227 7.49e-68 229.0 COG0577@1|root,COG0577@2|Bacteria,4P0EI@976|Bacteroidetes,1IUSV@117747|Sphingobacteriia 976|Bacteroidetes V MacB-like periplasmic core domain - - - - - - - - - - - - FtsX,MacB_PCD k59_1703888_1 1298864.AUEQ01000014_gene416 9.22e-07 52.0 COG1309@1|root,COG1309@2|Bacteria,2H0KR@201174|Actinobacteria,23C9G@1762|Mycobacteriaceae 201174|Actinobacteria K Bacterial regulatory proteins, tetR family - - - ko:K22107 - - - - ko00000,ko03000 - - - TetR_N k59_1138954_1 1415778.JQMM01000001_gene683 1.81e-69 221.0 COG0547@1|root,COG0547@2|Bacteria,1MUPV@1224|Proteobacteria,1RNXV@1236|Gammaproteobacteria,1J4GF@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria F Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) trpD GO:0000162,GO:0003674,GO:0003824,GO:0004048,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.18 ko:K00766 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R01073 RC00440 ko00000,ko00001,ko00002,ko01000 - - iJN746.PP_0421 Glycos_trans_3N,Glycos_transf_3 k59_913240_1 991905.SL003B_2151 7.05e-72 237.0 COG1012@1|root,COG2030@1|root,COG1012@2|Bacteria,COG2030@2|Bacteria,1MWD4@1224|Proteobacteria,2TUPI@28211|Alphaproteobacteria 28211|Alphaproteobacteria CI phenylacetic acid degradation protein paaN - 1.2.1.91,3.3.2.12 ko:K02618 ko00360,ko01120,map00360,map01120 - R09820,R09836 RC00080,RC02667 ko00000,ko00001,ko01000 - - - Aldedh,MaoC_dehydratas k59_1703889_1 1121897.AUGO01000008_gene2565 2.15e-105 326.0 COG1472@1|root,COG1472@2|Bacteria,4NE90@976|Bacteroidetes,1HX27@117743|Flavobacteriia,2NSID@237|Flavobacterium 976|Bacteroidetes G Belongs to the glycosyl hydrolase 3 family - - 3.2.1.21 ko:K05349 ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110 - R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040 RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248 ko00000,ko00001,ko01000 - GH3 - Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C k59_1534779_1 1122137.AQXF01000003_gene1968 3.34e-115 346.0 COG0654@1|root,COG0654@2|Bacteria,1NSGN@1224|Proteobacteria,2UPGQ@28211|Alphaproteobacteria 28211|Alphaproteobacteria CH Tryptophan halogenase - - 1.14.19.9 ko:K14266 ko00404,ko01130,map00404,map01130 M00789,M00790 R09570 RC00949 ko00000,ko00001,ko00002,ko01000 - - - Trp_halogenase k59_1534779_2 1122137.AQXF01000003_gene1969 2.86e-103 323.0 COG1472@1|root,COG1472@2|Bacteria,1MVIV@1224|Proteobacteria,2TS28@28211|Alphaproteobacteria 28211|Alphaproteobacteria G Belongs to the glycosyl hydrolase 3 family - - 3.2.1.21 ko:K05349 ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110 - R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040 RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248 ko00000,ko00001,ko01000 - GH3 - Glyco_hydro_3,Glyco_hydro_3_C k59_1590690_1 1499686.BN1079_00662 3.72e-61 208.0 COG0296@1|root,COG0296@2|Bacteria,1MVM7@1224|Proteobacteria,1SYH1@1236|Gammaproteobacteria 1236|Gammaproteobacteria G Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position glgB - 2.4.1.18 ko:K00700 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R02110 - ko00000,ko00001,ko00002,ko01000,ko04147 - CBM48,GH13 - Alpha-amylase,Alpha-amylase_C,CBM_48 k59_1647845_1 667014.Thein_1415 6.29e-16 80.5 COG0755@1|root,COG0755@2|Bacteria,2GGYG@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria O Cytochrome C assembly protein - - - - - - - - - - - - Cytochrom_C_asm k59_630583_2 1122137.AQXF01000001_gene2906 6.37e-42 139.0 COG2827@1|root,COG2827@2|Bacteria,1N2X6@1224|Proteobacteria,2UCV1@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Excinuclease ABC - - - ko:K07461 - - - - ko00000 - - - GIY-YIG k59_630583_4 1122137.AQXF01000001_gene2904 1.71e-27 104.0 COG0353@1|root,COG0353@2|Bacteria,1MV9Q@1224|Proteobacteria,2TRZM@28211|Alphaproteobacteria 28211|Alphaproteobacteria L May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO recR - - ko:K06187 ko03440,map03440 - - - ko00000,ko00001,ko03400 - - - RecR,Toprim_4 k59_1760555_1 452637.Oter_0878 4.06e-06 47.4 COG0712@1|root,COG0712@2|Bacteria,46TC4@74201|Verrucomicrobia,3K886@414999|Opitutae 414999|Opitutae C ATP synthase delta (OSCP) subunit - - - ko:K02113 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - OSCP k59_1760555_2 1207076.ALAT01000183_gene3031 4.53e-43 155.0 COG0056@1|root,COG0056@2|Bacteria,1MUG7@1224|Proteobacteria,1RP4V@1236|Gammaproteobacteria,1Z15X@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria C Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit atpA GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045261,GO:0045262,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 3.6.3.14 ko:K02111 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - iSbBS512_1146.SbBS512_E4187 ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N k59_574062_1 876044.IMCC3088_1311 2.16e-51 182.0 COG0243@1|root,COG0243@2|Bacteria,1NR6J@1224|Proteobacteria,1RN6S@1236|Gammaproteobacteria,1J7RY@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - - - - - - - - - - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding k59_292340_1 1229909.NSED_06535 1.02e-19 92.0 arCOG03042@1|root,arCOG03042@2157|Archaea 2157|Archaea KLT PFAM Tetratricopeptide repeat - - - - - - - - - - - - TPR_1,TPR_16,TPR_2,TPR_8 k59_1252314_1 1288494.EBAPG3_14290 1.54e-61 197.0 COG1381@1|root,COG1381@2|Bacteria,1RHIC@1224|Proteobacteria,2VJUC@28216|Betaproteobacteria,372H0@32003|Nitrosomonadales 28216|Betaproteobacteria L Involved in DNA repair and RecF pathway recombination recO - - ko:K03584 ko03440,map03440 - - - ko00000,ko00001,ko03400 - - - RecO_C,RecO_N k59_969390_1 159450.NH14_07135 0.000192 46.2 COG0560@1|root,COG0560@2|Bacteria,1RA1A@1224|Proteobacteria,2VMGV@28216|Betaproteobacteria,1K0JT@119060|Burkholderiaceae 28216|Betaproteobacteria E HAD-superfamily hydrolase, subfamily IB (PSPase-like) - - - - - - - - - - - - HAD k59_1421305_1 1122137.AQXF01000001_gene3028 2.55e-54 187.0 COG0815@1|root,COG0815@2|Bacteria,1MUBU@1224|Proteobacteria,2TQRC@28211|Alphaproteobacteria 28211|Alphaproteobacteria M Transfers the fatty acyl group on membrane lipoproteins lnt - - ko:K03820 - - - - ko00000,ko01000 - GT2 - CN_hydrolase k59_1760581_1 158500.BV97_02679 3.1e-63 206.0 COG1975@1|root,COG1975@2|Bacteria,1MXKU@1224|Proteobacteria,2TUF3@28211|Alphaproteobacteria,2K17D@204457|Sphingomonadales 204457|Sphingomonadales O Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family - - - ko:K07402 - - - - ko00000 - - - XdhC_C,XdhC_CoxI k59_574080_1 436308.Nmar_1203 2.22e-30 115.0 arCOG10580@1|root,arCOG10580@2157|Archaea 436308.Nmar_1203|- - - - - - - - - - - - - - - - k59_574080_2 981336.F944_02788 1.02e-10 65.1 COG0643@1|root,COG0745@1|root,COG2198@1|root,COG0643@2|Bacteria,COG0745@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,1RMS6@1236|Gammaproteobacteria,3NII0@468|Moraxellaceae 1236|Gammaproteobacteria T Signal transducing histidine kinase, homodimeric domain chpA - - ko:K02487,ko:K06596 ko02020,ko02025,map02020,map02025 M00507 - - ko00000,ko00001,ko00002,ko01001,ko02022,ko02035 - - - CheW,H-kinase_dim,HATPase_c,Hpt,Response_reg k59_1760592_1 1038860.AXAP01000015_gene2094 6.47e-132 395.0 COG3957@1|root,COG3957@2|Bacteria,1MVSE@1224|Proteobacteria,2TU2E@28211|Alphaproteobacteria,3JRH2@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria G aldehyde-lyase activity xfp - 4.1.2.22,4.1.2.9 ko:K01621 ko00030,ko00710,ko01100,ko01120,map00030,map00710,map01100,map01120 - R00761,R01621 RC00032,RC00226 ko00000,ko00001,ko01000 - - - XFP,XFP_C,XFP_N k59_1308880_1 1379270.AUXF01000005_gene637 1.2e-81 255.0 COG0498@1|root,COG0498@2|Bacteria,1ZSVV@142182|Gemmatimonadetes 142182|Gemmatimonadetes E Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine - - 4.2.3.1 ko:K01733 ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230 M00018 R01466,R05086 RC00017,RC00526 ko00000,ko00001,ko00002,ko01000 - - - PALP k59_1534830_2 436308.Nmar_0200 1.3e-57 183.0 arCOG08634@1|root,arCOG08634@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_743875_1 517418.Ctha_2061 1.13e-42 160.0 COG1596@1|root,COG1596@2|Bacteria,1FF7A@1090|Chlorobi 1090|Chlorobi M Capsule biosynthesis GfcC - - - - - - - - - - - - Caps_synth_GfcC,Poly_export,SLBB k59_574099_1 661367.LLO_0482 2.1e-12 64.3 COG0049@1|root,COG0049@2|Bacteria,1MXC8@1224|Proteobacteria,1RN77@1236|Gammaproteobacteria,1JDP5@118969|Legionellales 118969|Legionellales J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA rpsG GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02992 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S7 k59_574099_2 28229.ND2E_1696 1.58e-74 224.0 COG0048@1|root,COG0048@2|Bacteria,1RCWY@1224|Proteobacteria,1S3WB@1236|Gammaproteobacteria,2Q6PP@267889|Colwelliaceae 1236|Gammaproteobacteria J Ribosomal protein S12/S23 rpsL GO:0000372,GO:0000375,GO:0000376,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008380,GO:0009058,GO:0009059,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010604,GO:0010628,GO:0015935,GO:0016070,GO:0019219,GO:0019222,GO:0019538,GO:0019843,GO:0022626,GO:0022627,GO:0031323,GO:0031325,GO:0032991,GO:0033120,GO:0034336,GO:0034337,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043484,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0045935,GO:0046483,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990145,GO:1990904 - ko:K02950 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosom_S12_S23 k59_1760604_1 1121937.AUHJ01000017_gene3009 6.21e-24 105.0 COG1262@1|root,COG1262@2|Bacteria,1NQ5K@1224|Proteobacteria,1RQVS@1236|Gammaproteobacteria,46674@72275|Alteromonadaceae 1236|Gammaproteobacteria S PEGA domain - - - - - - - - - - - - FGE-sulfatase,PEGA k59_235095_1 649349.Lbys_1449 1.9e-19 87.0 COG3970@1|root,COG3970@2|Bacteria,4NGTH@976|Bacteroidetes,47MQU@768503|Cytophagia 976|Bacteroidetes S PFAM fumarylacetoacetate (FAA) hydrolase - - 4.2.1.141 ko:K14259 ko00040,map00040 - R09186 RC00429 ko00000,ko00001,ko01000 - - - FAA_hydrolase k59_235095_2 926556.Echvi_3768 3.78e-17 80.9 COG2610@1|root,COG2610@2|Bacteria,4NFQH@976|Bacteroidetes,47JEB@768503|Cytophagia 976|Bacteroidetes EG H gluconate symporter and related - - - ko:K03299 - - - - ko00000,ko02000 2.A.8 - - GntP_permease k59_1027009_1 285535.JOEY01000038_gene2800 1.42e-44 156.0 COG1228@1|root,COG1228@2|Bacteria,2GMUS@201174|Actinobacteria 201174|Actinobacteria Q amidohydrolase - - - - - - - - - - - - Amidohydro_1 k59_1027009_2 1144307.PMI04_01601 1.15e-27 110.0 COG0654@1|root,COG0654@2|Bacteria,1MX9R@1224|Proteobacteria,2TR4U@28211|Alphaproteobacteria,2K3D6@204457|Sphingomonadales 204457|Sphingomonadales CH FAD binding domain - - 1.14.13.127 ko:K05712 ko00360,ko01120,ko01220,map00360,map01120,map01220 M00545 R06786,R06787 RC00236 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_3 k59_1139043_1 1123503.KB908056_gene1801 2.97e-11 68.9 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,2TQR7@28211|Alphaproteobacteria,2KH9A@204458|Caulobacterales 204458|Caulobacterales T histidine kinase HAMP region domain protein - - - - - - - - - - - - MCPsignal k59_800829_1 1229909.NSED_01295 5.17e-130 377.0 COG0649@1|root,arCOG01548@2157|Archaea,41S62@651137|Thaumarchaeota 651137|Thaumarchaeota C Belongs to the complex I 49 kDa subunit family - - 1.6.5.3 ko:K00333 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_49kDa k59_687136_1 215803.DB30_3583 1.13e-10 61.2 COG5434@1|root,COG5434@2|Bacteria,1MUGF@1224|Proteobacteria,43802@68525|delta/epsilon subdivisions,2X39Z@28221|Deltaproteobacteria,2YV1S@29|Myxococcales 28221|Deltaproteobacteria M Belongs to the glycosyl hydrolase 28 family - - - - - - - - - - - - - k59_687136_2 1122137.AQXF01000001_gene3261 4.82e-52 183.0 COG1629@1|root,COG1629@2|Bacteria,COG4771@2|Bacteria,1MWKN@1224|Proteobacteria,2VFCK@28211|Alphaproteobacteria 28211|Alphaproteobacteria P TonB dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_687137_1 1415778.JQMM01000001_gene1238 9.23e-49 175.0 COG0542@1|root,COG0542@2|Bacteria,1MURH@1224|Proteobacteria,1RN55@1236|Gammaproteobacteria,1J534@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE clpB GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0006950,GO:0006986,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009266,GO:0009408,GO:0009628,GO:0010033,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030554,GO:0031249,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0035966,GO:0036094,GO:0042221,GO:0042623,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564 - ko:K03695 ko04213,map04213 - - - ko00000,ko00001,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N k59_1195665_1 247633.GP2143_09080 5.35e-65 217.0 COG0471@1|root,COG0471@2|Bacteria,1MU0K@1224|Proteobacteria,1RMI1@1236|Gammaproteobacteria,1J4XJ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P COG0471 Di- and tricarboxylate transporters - - - - - - - - - - - - CitMHS,TrkA_C k59_1365421_1 511062.GU3_00190 3.17e-115 343.0 COG0161@1|root,COG0161@2|Bacteria,1MU2N@1224|Proteobacteria,1RNW9@1236|Gammaproteobacteria,1Y586@135624|Aeromonadales 135624|Aeromonadales E Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family - - 2.6.1.113 ko:K12256 ko00330,ko01100,map00330,map01100 - R08714 RC00008,RC00062 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_3 k59_404768_1 1122137.AQXF01000002_gene316 7.14e-119 363.0 COG1452@1|root,COG1452@2|Bacteria,1MUJC@1224|Proteobacteria,2TR3B@28211|Alphaproteobacteria 28211|Alphaproteobacteria M Involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane lptD - - ko:K04744 - - - - ko00000,ko02000 1.B.42.1 - - OstA,OstA_C k59_1027024_1 1122137.AQXF01000004_gene1603 2.59e-92 284.0 COG0593@1|root,COG0593@2|Bacteria,1MU5H@1224|Proteobacteria,2TT03@28211|Alphaproteobacteria 28211|Alphaproteobacteria L it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids dnaA GO:0003674,GO:0003676,GO:0003677,GO:0003688,GO:0003690,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0034641,GO:0034645,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901576,GO:1990837 - ko:K02313 ko02020,ko04112,map02020,map04112 - - - ko00000,ko00001,ko03032,ko03036 - - - Bac_DnaA,Bac_DnaA_C,DnaA_N k59_858304_1 340177.Cag_1242 8.74e-05 50.4 COG0689@1|root,COG0726@1|root,COG1785@1|root,COG2133@1|root,COG2304@1|root,COG2911@1|root,COG2931@1|root,COG3210@1|root,COG3898@1|root,COG4254@1|root,COG4932@1|root,COG0689@2|Bacteria,COG0726@2|Bacteria,COG1785@2|Bacteria,COG2133@2|Bacteria,COG2304@2|Bacteria,COG2911@2|Bacteria,COG2931@2|Bacteria,COG3210@2|Bacteria,COG3898@2|Bacteria,COG4254@2|Bacteria,COG4932@2|Bacteria 2|Bacteria M domain protein rph GO:0003674,GO:0003824,GO:0004518,GO:0004540,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006401,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016075,GO:0016787,GO:0016788,GO:0019439,GO:0022613,GO:0031123,GO:0031125,GO:0034470,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0042254,GO:0043170,GO:0043628,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0140098,GO:1901360,GO:1901361,GO:1901575 2.7.7.56,3.1.3.1,3.4.24.40,3.6.1.66 ko:K00989,ko:K01077,ko:K01406,ko:K02428,ko:K20276,ko:K21430 ko00230,ko00730,ko00790,ko01100,ko01503,ko02020,ko02024,map00230,map00730,map00790,map01100,map01503,map02020,map02024 M00126 R00426,R00720,R01855,R02100,R02135,R02720,R03531,R04620 RC00002,RC00017 ko00000,ko00001,ko00002,ko00537,ko01000,ko01002,ko03016,ko04147 - - - RNase_PH,RNase_PH_C k59_1253382_1 748658.KB907313_gene2181 1.52e-34 132.0 COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,1RPCB@1236|Gammaproteobacteria,1WWYF@135613|Chromatiales 135613|Chromatiales O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner lon - 3.4.21.53 ko:K01338 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - AAA,LON_substr_bdg,Lon_C k59_1309930_1 106370.Francci3_1660 1.06e-76 243.0 COG0719@1|root,COG0719@2|Bacteria,2GKCZ@201174|Actinobacteria,4ERKY@85013|Frankiales 201174|Actinobacteria O TIGRFAM FeS assembly protein SufB sufB GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016788,GO:0034641,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:1901360 - ko:K09014 - - - - ko00000 - - - UPF0051 k59_970149_1 1313172.YM304_30930 5.3e-70 221.0 COG3383@1|root,COG3383@2|Bacteria,2GKBP@201174|Actinobacteria 201174|Actinobacteria C 2Fe-2S iron-sulfur cluster binding domain - - 1.6.5.3 ko:K00336 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Fe_hyd_SSU,Fe_hyd_lg_C,Fer2_4,Fer4,Fer4_6,Fer4_7,Molybdop_Fe4S4,NADH-G_4Fe-4S_3 k59_970149_2 666684.AfiDRAFT_3440 0.000779 42.7 COG1894@1|root,COG1905@1|root,COG1894@2|Bacteria,COG1905@2|Bacteria,1MV8F@1224|Proteobacteria,2TR1V@28211|Alphaproteobacteria,3JRTE@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria C NADH-ubiquinone oxidoreductase-F iron-sulfur binding region fdsB - 1.12.1.2,1.6.5.3 ko:K00124,ko:K00335,ko:K18005 ko00190,ko00630,ko00680,ko01100,ko01120,ko01200,map00190,map00630,map00680,map01100,map01120,map01200 M00144 R00519,R11945 RC00061,RC02796 ko00000,ko00001,ko00002,ko01000 3.D.1 - - 2Fe-2S_thioredx,Complex1_51K,NADH_4Fe-4S,SLBB k59_1479748_1 76114.ebA3040 5.15e-10 68.2 COG0768@1|root,COG0768@2|Bacteria,1MV8C@1224|Proteobacteria,2VHBZ@28216|Betaproteobacteria,2KUYH@206389|Rhodocyclales 206389|Rhodocyclales M Catalyzes cross-linking of the peptidoglycan cell wall mrdA - 3.4.16.4 ko:K05515 ko00550,ko01501,map00550,map01501 - - - ko00000,ko00001,ko01000,ko01011 - - - PBP_dimer,Transpeptidase k59_1591772_1 631362.Thi970DRAFT_01750 1.65e-39 155.0 COG0715@1|root,COG5002@1|root,COG0715@2|Bacteria,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,1T1JE@1236|Gammaproteobacteria 1236|Gammaproteobacteria T Histidine kinase - - - - - - - - - - - - HATPase_c,HisKA,Hpt,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg,SBP_bac_3 k59_1253396_1 1255043.TVNIR_3026 3.77e-139 407.0 COG0843@1|root,COG0843@2|Bacteria,1MU7S@1224|Proteobacteria,1RPC3@1236|Gammaproteobacteria,1WWX1@135613|Chromatiales 135613|Chromatiales C Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B - - 1.9.3.1 ko:K02274 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6 - - COX1 k59_405750_1 1122137.AQXF01000003_gene2137 1.05e-61 204.0 COG0642@1|root,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,2TRHH@28211|Alphaproteobacteria 28211|Alphaproteobacteria T Histidine kinase - - - - - - - - - - - - HATPase_c,HisKA,PAS_4,PAS_7 k59_405750_2 1121935.AQXX01000131_gene2844 9.51e-79 236.0 COG0346@1|root,COG0346@2|Bacteria,1RCYX@1224|Proteobacteria,1S1Z9@1236|Gammaproteobacteria,1XJS8@135619|Oceanospirillales 135619|Oceanospirillales E Glyoxalase bleomycin resistance protein dioxygenase - - 4.4.1.5 ko:K01759 ko00620,map00620 - R02530 RC00004,RC00740 ko00000,ko00001,ko01000 - - - Glyoxalase k59_405750_3 1122137.AQXF01000003_gene2135 3.08e-72 220.0 COG1956@1|root,COG1956@2|Bacteria,1RDBM@1224|Proteobacteria,2U595@28211|Alphaproteobacteria 28211|Alphaproteobacteria T COG1956 GAF domain-containing protein msrC - 1.8.4.14 ko:K08968 ko00270,map00270 - R02025 RC00639 ko00000,ko00001,ko01000 - - - GAF_2 k59_1083646_1 641526.ADIWIN_1018 8.25e-97 304.0 COG4772@1|root,COG4772@2|Bacteria,4NEJW@976|Bacteroidetes,1HWWZ@117743|Flavobacteriia 976|Bacteroidetes P TonB-dependent receptor - - - - - - - - - - - - CarbopepD_reg_2,Plug,TonB_dep_Rec k59_293177_1 1140.Synpcc7942_1708 1.83e-223 636.0 COG0339@1|root,COG0339@2|Bacteria,1G05V@1117|Cyanobacteria,1GZBK@1129|Synechococcus 1117|Cyanobacteria E COG0339 Zn-dependent oligopeptidases prlC - 3.4.24.70 ko:K01414 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M3 k59_518446_1 314285.KT71_05607 7.36e-93 282.0 COG3316@1|root,COG3316@2|Bacteria,1RHKZ@1224|Proteobacteria,1S7XK@1236|Gammaproteobacteria,1JC1M@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L Transposase IS66 family - - - ko:K07484 - - - - ko00000 - - - DDE_Tnp_IS66,DDE_Tnp_IS66_C,LZ_Tnp_IS66,zf-IS66 k59_1591784_1 1121874.KB892377_gene834 3.08e-10 61.2 COG1011@1|root,COG1011@2|Bacteria,1V6I4@1239|Firmicutes,3VR6C@526524|Erysipelotrichia 526524|Erysipelotrichia S Haloacid dehalogenase-like hydrolase - - - - - - - - - - - - HAD_2 k59_1591789_1 2340.JV46_20200 8.45e-135 392.0 COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,1RMYC@1236|Gammaproteobacteria 1236|Gammaproteobacteria P ATPase, P-type (transporting), HAD superfamily, subfamily IC - - - - - - - - - - - - Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase k59_1591791_1 314345.SPV1_01487 3.43e-73 226.0 293CN@1|root,2ZQV6@2|Bacteria,1RDZB@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_640746_7 395495.Lcho_2244 0.000154 47.8 2CDSP@1|root,32RYD@2|Bacteria,1N213@1224|Proteobacteria,2VUV3@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_1037270_1 321332.CYB_2518 2.2e-49 169.0 COG3001@1|root,COG3001@2|Bacteria,1G040@1117|Cyanobacteria,1GZY8@1129|Synechococcus 1117|Cyanobacteria G COG3001 Fructosamine-3-kinase - GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0044237 - - - - - - - - - - Fructosamin_kin k59_1037270_2 870187.Thini_3187 2.1e-50 173.0 COG0258@1|root,COG0258@2|Bacteria,1RAAR@1224|Proteobacteria,1S54F@1236|Gammaproteobacteria,463Q1@72273|Thiotrichales 72273|Thiotrichales L Helix-hairpin-helix class 2 (Pol1 family) motifs - - - - - - - - - - - - 5_3_exonuc,5_3_exonuc_N k59_189099_1 85643.Tmz1t_2488 2.4e-18 84.7 COG1960@1|root,COG1960@2|Bacteria,1MU20@1224|Proteobacteria,2VNQH@28216|Betaproteobacteria,2KVPC@206389|Rhodocyclales 206389|Rhodocyclales C Acyl-CoA dehydrogenase N terminal - - - ko:K20035 ko00920,map00920 - R11130 RC03363 ko00000,ko00001,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_C,Acyl-CoA_dh_M,Acyl-CoA_dh_N,AcylCoA_DH_N k59_189099_2 1500893.JQNB01000001_gene709 1.28e-22 96.3 COG2224@1|root,COG2224@2|Bacteria,1MWIF@1224|Proteobacteria,1RQAK@1236|Gammaproteobacteria,1X3U8@135614|Xanthomonadales 135614|Xanthomonadales C Catalyzes the reversible formation of glyoxylate and succinate from isocitrate aceA - 4.1.3.1 ko:K01637 ko00630,ko01100,ko01110,ko01120,ko01200,map00630,map01100,map01110,map01120,map01200 M00012 R00479 RC00311,RC00313 ko00000,ko00001,ko00002,ko01000 - - - ICL k59_526972_1 700015.Corgl_0595 1.46e-15 77.8 COG0500@1|root,COG0500@2|Bacteria,2I6HE@201174|Actinobacteria,4CW1I@84998|Coriobacteriia 84998|Coriobacteriia Q methyltransferase - - - - - - - - - - - - Methyltransf_11,Methyltransf_23,Methyltransf_25 k59_753512_1 562970.Btus_0142 1.47e-29 112.0 COG0244@1|root,COG0244@2|Bacteria,1V3JJ@1239|Firmicutes,4HH0N@91061|Bacilli,278CE@186823|Alicyclobacillaceae 91061|Bacilli J Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors rplJ GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02864 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L10 k59_753512_2 1238182.C882_2938 1.59e-39 136.0 COG0222@1|root,COG0222@2|Bacteria,1RGU4@1224|Proteobacteria,2U9FX@28211|Alphaproteobacteria,2JSU1@204441|Rhodospirillales 204441|Rhodospirillales J Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation rplL - - ko:K02935 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L12,Ribosomal_L12_N k59_583963_2 1449976.KALB_4802 2.12e-121 354.0 2C1EG@1|root,2Z7MZ@2|Bacteria,2GK4W@201174|Actinobacteria,4DZP1@85010|Pseudonocardiales 201174|Actinobacteria - - - - - - - - - - - - - - - k59_978682_1 452637.Oter_0855 1.29e-62 209.0 COG2265@1|root,COG2265@2|Bacteria,46SYJ@74201|Verrucomicrobia,3K7H7@414999|Opitutae 414999|Opitutae J Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family - - 2.1.1.190,2.1.1.35 ko:K03215,ko:K15331 - - - - ko00000,ko01000,ko03009,ko03016 - - - TRAM,tRNA_U5-meth_tr k59_471056_1 436308.Nmar_1696 2.24e-19 84.7 COG0778@1|root,arCOG00288@2157|Archaea 2157|Archaea C Nitroreductase - - - - - - - - - - - - Nitroreductase k59_471056_2 1229909.NSED_05065 1.3e-53 170.0 arCOG07348@1|root,arCOG07348@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_1148806_1 345341.KUTG_05641 1.63e-97 303.0 COG0449@1|root,COG0449@2|Bacteria,2GKH0@201174|Actinobacteria,4DX4Z@85010|Pseudonocardiales 201174|Actinobacteria M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source glmS - 2.6.1.16 ko:K00820 ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931 - R00768 RC00010,RC00163,RC02752 ko00000,ko00001,ko01000,ko01002 - - - GATase_6,SIS k59_414535_1 930945.SiRe_2402 4.05e-17 79.7 COG0589@1|root,arCOG02053@2157|Archaea,2XQTK@28889|Crenarchaeota 28889|Crenarchaeota T PFAM UspA domain protein - - - - - - - - - - - - Usp k59_753516_1 883077.HMPREF9241_00001 8.26e-10 56.2 2DEPW@1|root,2ZNS6@2|Bacteria,2GWSK@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - - k59_1261803_1 595460.RRSWK_06759 1.4e-130 402.0 COG0643@1|root,COG0643@2|Bacteria,2IWWG@203682|Planctomycetes 203682|Planctomycetes T Signal transducing histidine kinase, homodimeric - - 2.7.13.3 ko:K02487,ko:K03407,ko:K06596 ko02020,ko02025,ko02030,map02020,map02025,map02030 M00506,M00507 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 - - - CheW,H-kinase_dim,HATPase_c,Hpt,Response_reg k59_867550_2 1171373.PACID_02270 3.96e-29 113.0 COG0205@1|root,COG0205@2|Bacteria,2GK6W@201174|Actinobacteria,4DPJ3@85009|Propionibacteriales 201174|Actinobacteria G Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis pfkA - 2.7.1.11,2.7.1.90 ko:K00850,ko:K21071 ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230 M00001,M00345 R00756,R00764,R02073,R03236,R03237,R03238,R03239,R04779 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000,ko01009,ko03019 - - - PFK k59_923221_1 118005.AWNK01000001_gene1846 4.02e-34 129.0 COG0722@1|root,COG0722@2|Bacteria 2|Bacteria E Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) aroF GO:0003674,GO:0003824,GO:0003849,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0019438,GO:0019752,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.54 ko:K01626 ko00400,ko01100,ko01110,ko01130,ko01230,ko02024,map00400,map01100,map01110,map01130,map01230,map02024 M00022 R01826 RC00435 ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_2375,iAPECO1_1312.APECO1_3932,iECOK1_1307.ECOK1_2946,iECS88_1305.ECS88_2787,iUMN146_1321.UM146_03705,iUTI89_1310.UTI89_C2934 DAHP_synth_1 k59_1488797_1 452662.SJA_C2-01350 7.19e-66 207.0 COG1116@1|root,COG1116@2|Bacteria,1MWZG@1224|Proteobacteria,2TT79@28211|Alphaproteobacteria,2K0H1@204457|Sphingomonadales 204457|Sphingomonadales P ABC transporter - - - ko:K02049 - M00188 - - ko00000,ko00002,ko02000 3.A.1.16,3.A.1.17 - - ABC_tran k59_1488797_2 158500.BV97_01717 3.23e-40 136.0 COG0864@1|root,COG0864@2|Bacteria,1RDN6@1224|Proteobacteria,2U61K@28211|Alphaproteobacteria,2K4CQ@204457|Sphingomonadales 204457|Sphingomonadales K Transcriptional regulator - - - ko:K07722 - - - - ko00000,ko03000 - - - NikR_C,RHH_1 k59_583974_1 1168034.FH5T_06355 1.44e-116 350.0 COG4565@1|root,COG4584@1|root,COG4565@2|Bacteria,COG4584@2|Bacteria,4NEY6@976|Bacteroidetes,2FMHY@200643|Bacteroidia 976|Bacteroidetes L COG4584 Transposase and inactivated derivatives - - - - - - - - - - - - HTH_11,HTH_23,rve k59_19439_2 1172180.KB911795_gene7772 9.22e-25 106.0 COG0438@1|root,COG0438@2|Bacteria,2GMXE@201174|Actinobacteria 201174|Actinobacteria M Glycosyl transferase - - - - - - - - - - - - Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1 k59_527003_1 1169152.AXVD01000031_gene2212 1.07e-51 178.0 COG3173@1|root,COG3173@2|Bacteria,2GJT0@201174|Actinobacteria,4FUKX@85025|Nocardiaceae 201174|Actinobacteria S Aminoglycoside phosphotransferase - - - - - - - - - - - - APH k59_527003_2 1005995.GTPT_1326 9.27e-07 51.6 COG0077@1|root,COG1605@1|root,COG0077@2|Bacteria,COG1605@2|Bacteria,1MU60@1224|Proteobacteria,1RNRD@1236|Gammaproteobacteria,4BTKR@82986|Tatumella 1236|Gammaproteobacteria E Prephenate dehydratase pheA GO:0003674,GO:0003824,GO:0004106,GO:0004664,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006558,GO:0006570,GO:0006571,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009094,GO:0009095,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016866,GO:0017144,GO:0019438,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902221,GO:1902223 4.2.1.51,5.4.99.5 ko:K14170 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00024,M00025 R00691,R01373,R01715 RC00360,RC03116 ko00000,ko00001,ko00002,ko01000 - - iECNA114_1301.ECNA114_2667 CM_2,DAHP_synth_1,PDT k59_471084_1 709991.Odosp_0307 2.17e-29 125.0 COG1295@1|root,COG1295@2|Bacteria,4NH0H@976|Bacteroidetes,2FP7P@200643|Bacteroidia,22WV5@171551|Porphyromonadaceae 976|Bacteroidetes S ribonuclease BN yihY - - ko:K07058 - - - - ko00000 - - - Virul_fac_BrkB k59_471084_2 1123073.KB899241_gene2335 1.06e-40 139.0 COG3791@1|root,COG3791@2|Bacteria,1RHWZ@1224|Proteobacteria,1S4HQ@1236|Gammaproteobacteria,1X72V@135614|Xanthomonadales 135614|Xanthomonadales S Glutathione-dependent formaldehyde-activating enzyme - - - - - - - - - - - - GFA k59_1601094_1 525898.Sdel_1788 5.03e-45 162.0 COG0399@1|root,COG0399@2|Bacteria,1MUPN@1224|Proteobacteria,42MA3@68525|delta/epsilon subdivisions,2YMI4@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E Belongs to the DegT DnrJ EryC1 family - - 1.17.1.1 ko:K12452 ko00520,map00520 - R03391,R03392 RC00230 ko00000,ko00001,ko01000 - - - DegT_DnrJ_EryC1 k59_189150_1 1088721.NSU_2459 2.05e-217 607.0 COG0795@1|root,COG0795@2|Bacteria,1MUF2@1224|Proteobacteria,2U55Q@28211|Alphaproteobacteria,2K07C@204457|Sphingomonadales 204457|Sphingomonadales S YjgP YjgQ family - - - ko:K07091 ko02010,map02010 M00320 - - ko00000,ko00001,ko00002,ko02000 1.B.42.1 - - YjgP_YjgQ k59_1037338_1 436308.Nmar_0380 1.12e-55 186.0 arCOG10517@1|root,arCOG10517@2157|Archaea,41T0I@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_753546_1 1415778.JQMM01000001_gene576 6.42e-95 290.0 COG0569@1|root,COG0569@2|Bacteria,1MW8R@1224|Proteobacteria,1RNVQ@1236|Gammaproteobacteria,1J4GQ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P COG0569 K transport systems, NAD-binding component trkA GO:0003674,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0015075,GO:0015672,GO:0016020,GO:0022857,GO:0030001,GO:0034220,GO:0051179,GO:0051234,GO:0055085,GO:0098655 - ko:K03499 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - iE2348C_1286.E2348C_3552 TrkA_C,TrkA_N k59_1601103_1 1206741.BAFX01000042_gene3063 1.13e-10 70.1 COG2909@1|root,COG3629@1|root,COG2909@2|Bacteria,COG3629@2|Bacteria,2GJAR@201174|Actinobacteria,4G9EW@85025|Nocardiaceae 201174|Actinobacteria KT Bacterial transcriptional activator domain - - - - - - - - - - - - AAA_16,BTAD,Trans_reg_C k59_1092483_1 684949.ATTJ01000002_gene175 1.17e-39 137.0 COG3832@1|root,COG3832@2|Bacteria 2|Bacteria J glyoxalase III activity - - - - - - - - - - - - 3-dmu-9_3-mt,AHSA1 k59_1092483_2 717785.HYPMC_3864 1.75e-39 134.0 COG0640@1|root,COG0640@2|Bacteria,1RH5P@1224|Proteobacteria,2U960@28211|Alphaproteobacteria,3N8NC@45401|Hyphomicrobiaceae 28211|Alphaproteobacteria K Bacterial regulatory protein, arsR family - - - - - - - - - - - - HTH_20 k59_527021_1 1229909.NSED_08465 9.83e-96 287.0 COG0122@1|root,arCOG00464@2157|Archaea,41SHE@651137|Thaumarchaeota 651137|Thaumarchaeota L 8-oxoguanine DNA glycosylase - - 4.2.99.18 ko:K03660 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - HhH-GPD k59_1544933_1 1227349.C170_00119 2.55e-42 159.0 COG0001@1|root,COG0318@1|root,COG1020@1|root,COG3321@1|root,COG0001@2|Bacteria,COG0318@2|Bacteria,COG1020@2|Bacteria,COG3321@2|Bacteria,1TPTH@1239|Firmicutes,4HAHU@91061|Bacilli,26Q93@186822|Paenibacillaceae 91061|Bacilli Q Non-ribosomal peptide synthetase modules and related proteins - - - - - - - - - - - - AMP-binding,AMP-binding_C,Aminotran_3,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,Thioesterase,adh_short,ketoacyl-synt k59_1093713_1 1206731.BAGB01000172_gene274 1.66e-63 206.0 COG1541@1|root,COG1541@2|Bacteria,2IANT@201174|Actinobacteria,4FXTR@85025|Nocardiaceae 201174|Actinobacteria H Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA) - - - - - - - - - - - - - k59_1093713_2 298653.Franean1_4697 2e-70 227.0 COG1012@1|root,COG1012@2|Bacteria 2|Bacteria C belongs to the aldehyde dehydrogenase family luxC - 1.2.1.50 ko:K03400 ko02020,ko02024,map02020,map02024 - R10549 RC00004,RC00184 ko00000,ko00001,ko01000 - - - LuxC k59_133927_1 347834.RHE_CH01065 2.62e-46 166.0 COG0659@1|root,COG0659@2|Bacteria,1MX8F@1224|Proteobacteria,2U0IJ@28211|Alphaproteobacteria,4BM6J@82115|Rhizobiaceae 28211|Alphaproteobacteria P Sulfate permease family - - - - - - - - - - - - STAS_2,Sulfate_transp k59_360548_1 1224318.DT73_22040 1.16e-24 106.0 COG4584@1|root,COG4584@2|Bacteria,1MWIV@1224|Proteobacteria,1RQ9W@1236|Gammaproteobacteria 1236|Gammaproteobacteria L to Escherichia coli transposase for insertion sequence element IS21 IstA SW ISTA_ECOLI (P15025) (390 aa) fasta scores E() 3e-27, 33.1 id in 329 aa. Identical to the previously sequenced Yersinia pestis,Yersinia pseudotuberculosis and Escherichia coli pesticin plasmid insertion sequence transposase Y1055 TR P74993 (EMBL U59875) (340 aa) fasta scores E() 0, 100.0 id in 340 aa - - - - - - - - - - - - HTH_23,rve k59_528062_1 219305.MCAG_02249 1.71e-67 211.0 COG1335@1|root,COG1335@2|Bacteria,2I9AW@201174|Actinobacteria,4DA0A@85008|Micromonosporales 201174|Actinobacteria Q Isochorismatase family - - 3.5.1.110 ko:K09020 ko00240,ko01100,map00240,map01100 - R09947,R09980 RC02737,RC02738 ko00000,ko00001,ko01000 - - - Isochorismatase k59_133931_1 1522072.IL54_2259 3.36e-144 410.0 COG1024@1|root,COG1024@2|Bacteria,1QGFN@1224|Proteobacteria,2U3FJ@28211|Alphaproteobacteria,2K0W7@204457|Sphingomonadales 204457|Sphingomonadales I Enoyl-CoA hydratase/isomerase - - - - - - - - - - - - ECH_1 k59_303975_2 518766.Rmar_0637 5.8e-14 69.7 2FDJV@1|root,345M5@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_1262906_1 272560.BPSS2190 7.3e-12 70.9 COG4964@1|root,COG4964@2|Bacteria,1MV8G@1224|Proteobacteria,2VIVD@28216|Betaproteobacteria,1JZXV@119060|Burkholderiaceae 28216|Betaproteobacteria U Belongs to the GSP D family cpaC1 - - ko:K02280 - - - - ko00000,ko02035,ko02044 - - - BON,Secretin,T2SS-T3SS_pil_N k59_811802_1 46429.BV95_01230 1.24e-91 280.0 COG0526@1|root,COG0526@2|Bacteria,1RC8N@1224|Proteobacteria,2U7IW@28211|Alphaproteobacteria,2K9S5@204457|Sphingomonadales 204457|Sphingomonadales CO COG0526, thiol-disulfide isomerase and thioredoxins - - - - - - - - - - - - - k59_303983_1 797515.HMPREF9103_00168 3.14e-07 52.8 COG0589@1|root,COG0589@2|Bacteria,1VEJR@1239|Firmicutes,4HR56@91061|Bacilli,3F8D9@33958|Lactobacillaceae 91061|Bacilli T Universal stress protein family - - - - - - - - - - - - Usp k59_303983_2 436308.Nmar_1774 1.28e-07 53.5 COG0462@1|root,arCOG00067@2157|Archaea,41SH1@651137|Thaumarchaeota 651137|Thaumarchaeota F Ribose-phosphate pyrophosphokinase - - 2.7.6.1 ko:K00948 ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230 M00005 R01049 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - Pribosyl_synth,Pribosyltran,Pribosyltran_N k59_1546611_1 511145.b1479 7.95e-106 320.0 COG0281@1|root,COG0281@2|Bacteria,1MU0A@1224|Proteobacteria,1RQ11@1236|Gammaproteobacteria,3XNQS@561|Escherichia 1236|Gammaproteobacteria C malate dehydrogenase (decarboxylating) (NAD+) activity maeA GO:0003674,GO:0003824,GO:0004470,GO:0004471,GO:0004473,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006082,GO:0006090,GO:0006094,GO:0006108,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016051,GO:0016491,GO:0016614,GO:0016615,GO:0016616,GO:0019318,GO:0019319,GO:0019752,GO:0032787,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046364,GO:0055114,GO:0071704,GO:1901576 1.1.1.38,1.1.1.40 ko:K00027,ko:K00029 ko00620,ko00710,ko01100,ko01120,ko01200,ko02020,map00620,map00710,map01100,map01120,map01200,map02020 M00169,M00172 R00214,R00216 RC00105 ko00000,ko00001,ko00002,ko01000 - - iSbBS512_1146.SbBS512_E1742 Malic_M,malic k59_641845_1 1283299.AUKG01000001_gene3171 6.95e-38 142.0 COG0146@1|root,COG0146@2|Bacteria,2HWA8@201174|Actinobacteria,4CRNM@84995|Rubrobacteria 84995|Rubrobacteria EQ PFAM Hydantoinase B oxoprolinase - - 3.5.2.14 ko:K01474 ko00330,ko01100,map00330,map01100 - R03187 RC00632 ko00000,ko00001,ko01000 - - - Hydantoinase_B k59_1602744_1 247633.GP2143_09040 7.14e-309 888.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1J8T8@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_1602744_3 1254432.SCE1572_19035 1.96e-79 243.0 COG0670@1|root,COG0670@2|Bacteria,1R7VN@1224|Proteobacteria,43DVQ@68525|delta/epsilon subdivisions,2WZ04@28221|Deltaproteobacteria,2Z11K@29|Myxococcales 28221|Deltaproteobacteria S Belongs to the BI1 family - - - ko:K06890 - - - - ko00000 - - - Bax1-I k59_78380_1 158500.BV97_00990 5.19e-115 352.0 COG0741@1|root,COG0741@2|Bacteria,1MV3F@1224|Proteobacteria,2TRDB@28211|Alphaproteobacteria,2K0PK@204457|Sphingomonadales 204457|Sphingomonadales M COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains) - - - ko:K08309 - - - - ko00000,ko01000,ko01011 - GH23 - SLT k59_1771584_1 29540.C481_01957 3.46e-05 45.4 COG2217@1|root,arCOG01576@2157|Archaea,2XT3T@28890|Euryarchaeota,23S6X@183963|Halobacteria 183963|Halobacteria P copper-translocating P-type ATPase - - 3.6.3.4 ko:K01533 - - R00086 RC00002 ko00000,ko01000 3.A.3.5 - - E1-E2_ATPase,Hydrolase k59_1771584_2 192952.MM_1891 1.8e-09 62.4 COG0025@1|root,arCOG01961@2157|Archaea,2Y0UK@28890|Euryarchaeota,2NBGR@224756|Methanomicrobia 224756|Methanomicrobia P Sodium/hydrogen exchanger family - - - - - - - - - - - - Na_H_Exchanger k59_924436_1 1524467.IV04_09530 4.26e-104 325.0 COG0187@1|root,COG0187@2|Bacteria,1MVKT@1224|Proteobacteria,1RNB2@1236|Gammaproteobacteria,401QC@613|Serratia 1236|Gammaproteobacteria L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrB GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003916,GO:0003918,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006265,GO:0006351,GO:0006725,GO:0006807,GO:0006996,GO:0007059,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009295,GO:0009330,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017076,GO:0017111,GO:0018130,GO:0019438,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032774,GO:0032991,GO:0034335,GO:0034641,GO:0034645,GO:0034654,GO:0035639,GO:0036094,GO:0042221,GO:0042493,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051276,GO:0061505,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0097367,GO:0097659,GO:0140097,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901576 5.99.1.3 ko:K02470 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim k59_1659524_1 436308.Nmar_1684 4.76e-82 256.0 arCOG08795@1|root,arCOG08795@2157|Archaea 2157|Archaea C copper ion binding - - - - - - - - - - - - - k59_472252_1 1229909.NSED_09410 1.02e-109 327.0 COG0520@1|root,arCOG00065@2157|Archaea,41SYH@651137|Thaumarchaeota 651137|Thaumarchaeota E Aminotransferase class-V - - 2.8.1.7,4.4.1.16 ko:K11717 ko00450,ko01100,map00450,map01100 - R03599,R11528 RC00961,RC01789,RC02313 ko00000,ko00001,ko01000 - - - Aminotran_5 k59_924438_1 1229909.NSED_09095 3.02e-99 303.0 COG0661@1|root,arCOG01189@2157|Archaea,41SYQ@651137|Thaumarchaeota 651137|Thaumarchaeota S ABC1 family - - - - - - - - - - - - ABC1 k59_1602756_1 1266925.JHVX01000007_gene2349 4.67e-172 494.0 COG0154@1|root,COG0154@2|Bacteria,1MUVQ@1224|Proteobacteria,2VIG3@28216|Betaproteobacteria,372CW@32003|Nitrosomonadales 28216|Betaproteobacteria J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) gatA - 6.3.5.6,6.3.5.7 ko:K02433 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - Amidase k59_1715574_1 1380387.JADM01000008_gene954 2.41e-34 127.0 COG1403@1|root,COG1403@2|Bacteria,1RIBS@1224|Proteobacteria,1S88N@1236|Gammaproteobacteria 1236|Gammaproteobacteria V Bacteriophage Lambda NinG protein - - - - - - - - - - - - NinG k59_1490379_1 1235279.C772_02546 1.67e-102 317.0 COG2936@1|root,COG2936@2|Bacteria,1TT0H@1239|Firmicutes,4HB0H@91061|Bacilli,26H03@186818|Planococcaceae 91061|Bacilli S X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain cocE - - ko:K06978 - - - - ko00000 - - - PepX_C,Peptidase_S15 k59_1546640_1 1380355.JNIJ01000022_gene3581 1.24e-101 319.0 COG2303@1|root,COG2303@2|Bacteria,1MV19@1224|Proteobacteria,2TQKQ@28211|Alphaproteobacteria,3JSS3@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria E GMC oxidoreductase - - 1.1.99.1 ko:K00108 ko00260,ko01100,map00260,map01100 M00555 R01025 RC00087 ko00000,ko00001,ko00002,ko01000 - - - GMC_oxred_C,GMC_oxred_N k59_698754_1 1244869.H261_06244 1.2e-62 200.0 COG0020@1|root,COG0020@2|Bacteria,1MVP1@1224|Proteobacteria,2TTVJ@28211|Alphaproteobacteria,2JPMI@204441|Rhodospirillales 204441|Rhodospirillales I Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids uppS - 2.5.1.31 ko:K00806 ko00900,ko01110,map00900,map01110 - R06447 RC00279,RC02839 ko00000,ko00001,ko01000,ko01006 - - - Prenyltransf k59_1150411_1 33876.JNXY01000015_gene7541 3.73e-05 47.4 COG4152@1|root,COG4152@2|Bacteria,2I2U6@201174|Actinobacteria,4DMD2@85008|Micromonosporales 201174|Actinobacteria S AAA domain, putative AbiEii toxin, Type IV TA system - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - AAA_21,ABC_tran,DUF4162 k59_1150411_2 211114.JOEF01000038_gene6845 2.76e-19 94.7 COG1277@1|root,COG1277@2|Bacteria,2ID14@201174|Actinobacteria,4E7AP@85010|Pseudonocardiales 201174|Actinobacteria S ABC-2 family transporter protein - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_2 k59_304021_1 1260251.SPISAL_05785 3.88e-80 250.0 COG0172@1|root,COG0172@2|Bacteria,1MUJF@1224|Proteobacteria,1RNAQ@1236|Gammaproteobacteria,1WX7U@135613|Chromatiales 135613|Chromatiales J Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) serS - 6.1.1.11 ko:K01875 ko00970,map00970 M00359,M00360 R03662,R08218 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Seryl_tRNA_N,tRNA-synt_2b k59_304021_2 493475.GARC_5087 1.39e-05 46.2 COG2010@1|root,COG2010@2|Bacteria,1N5P8@1224|Proteobacteria,1S9K3@1236|Gammaproteobacteria,46AXG@72275|Alteromonadaceae 1236|Gammaproteobacteria C Cytochrome c - - - - - - - - - - - - Cytochrom_C k59_1602777_1 1121459.AQXE01000014_gene360 1.72e-44 153.0 2BHRH@1|root,32BUY@2|Bacteria,1MZ2C@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_585592_1 765911.Thivi_4549 1.22e-26 106.0 COG1355@1|root,COG1355@2|Bacteria,1MXK5@1224|Proteobacteria,1RQPK@1236|Gammaproteobacteria,1WX63@135613|Chromatiales 135613|Chromatiales S Belongs to the MEMO1 family - - - ko:K06990 - - - - ko00000,ko04812 - - - Memo k59_979943_1 1288494.EBAPG3_9310 2.09e-106 315.0 COG0568@1|root,COG0568@2|Bacteria,1MVWR@1224|Proteobacteria,2VI91@28216|Betaproteobacteria,3723K@32003|Nitrosomonadales 28216|Betaproteobacteria K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is involved in regulation of expression of heat shock genes rpoH - - ko:K03089 - - - - ko00000,ko03021 - - - Sigma70_r1_2,Sigma70_r2,Sigma70_r4 k59_246520_1 1123276.KB893246_gene854 3.67e-61 206.0 COG3385@1|root,COG3385@2|Bacteria,4P02Y@976|Bacteroidetes,47TUA@768503|Cytophagia 976|Bacteroidetes L Transposase DDE domain - - - - - - - - - - - - DDE_Tnp_1 k59_1207309_1 435591.BDI_2980 8.82e-31 125.0 COG2189@1|root,COG2189@2|Bacteria,4NFKE@976|Bacteroidetes,2FNVJ@200643|Bacteroidia 976|Bacteroidetes L COG2189 Adenine specific DNA methylase Mod - - 2.1.1.72 ko:K00571,ko:K07316 - - - - ko00000,ko01000,ko02048 - - - N6_N4_Mtase k59_811837_1 1278311.AUAL01000001_gene107 2.12e-20 95.5 COG1132@1|root,COG1132@2|Bacteria,3WSYI@544448|Tenericutes 544448|Tenericutes V COG1132 ABC-type multidrug transport system, ATPase and permease components - - - ko:K18890 ko02010,map02010 M00707 - - ko00000,ko00001,ko00002,ko02000 3.A.1.106.13,3.A.1.106.5 - - ABC_membrane,ABC_tran k59_1038930_1 314287.GB2207_11783 3.46e-47 164.0 COG2270@1|root,COG2270@2|Bacteria,1QUVA@1224|Proteobacteria,1T226@1236|Gammaproteobacteria,1JC10@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S COG0477 Permeases of the major facilitator superfamily Z012_03780 - - ko:K08218 ko01501,map01501 M00628 - - ko00000,ko00001,ko00002,ko02000 2.A.1.25 - - MFS_1 k59_1490414_1 865937.Gilli_2150 5.86e-110 323.0 COG0180@1|root,COG0180@2|Bacteria,4NETX@976|Bacteroidetes,1HY8G@117743|Flavobacteriia,2P60M@244698|Gillisia 976|Bacteroidetes J tRNA synthetases class I (W and Y) trpS - 6.1.1.2 ko:K01867 ko00970,map00970 M00359,M00360 R03664 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_1b k59_416041_1 436308.Nmar_0402 7.37e-178 506.0 COG5253@1|root,arCOG04169@2157|Archaea,41S9X@651137|Thaumarchaeota 651137|Thaumarchaeota U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently secY - - ko:K03076 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5 - - Plug_translocon,SecY k59_1150444_1 1206731.BAGB01000167_gene958 1.31e-81 256.0 COG1071@1|root,COG1071@2|Bacteria,2GK3W@201174|Actinobacteria,4G0JR@85025|Nocardiaceae 201174|Actinobacteria C Dehydrogenase E1 component acoA - 1.2.4.1 ko:K00161,ko:K21416 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230 M00307 R00014,R00209,R01699,R03270 RC00004,RC00027,RC00627,RC02742,RC02744,RC02882 br01601,ko00000,ko00001,ko00002,ko01000 - - - E1_dh k59_1602812_1 156889.Mmc1_3646 9.81e-77 239.0 COG3298@1|root,COG3298@2|Bacteria,1MVZJ@1224|Proteobacteria 1224|Proteobacteria L 3'-5' exonuclease related to the exonuclease domain of PolB wlaX - - ko:K07501 - - - - ko00000 - - - DNA_pol_B_exo2 k59_1160145_1 379731.PST_1557 4.2e-79 249.0 COG0148@1|root,COG0148@2|Bacteria,1MU1N@1224|Proteobacteria,1RNQA@1236|Gammaproteobacteria,1YZY1@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria G Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis eno - 4.2.1.11 ko:K01689 ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066 M00001,M00002,M00003,M00346,M00394 R00658 RC00349 ko00000,ko00001,ko00002,ko01000,ko03019,ko04147 - - - Enolase_C,Enolase_N k59_1725750_1 1499967.BAYZ01000095_gene4213 1.76e-129 385.0 COG0364@1|root,COG0364@2|Bacteria,2NNUR@2323|unclassified Bacteria 2|Bacteria G Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone zwf GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 1.1.1.363,1.1.1.49 ko:K00036 ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230 M00004,M00006,M00008 R00835,R02736,R10907 RC00001,RC00066 ko00000,ko00001,ko00002,ko01000,ko04147 - - iIT341.HP1101 G6PD_C,G6PD_N k59_315084_1 702113.PP1Y_AT17039 1.42e-65 200.0 COG0093@1|root,COG0093@2|Bacteria,1RCWZ@1224|Proteobacteria,2U743@28211|Alphaproteobacteria,2K4G3@204457|Sphingomonadales 204457|Sphingomonadales J Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome rplN - - ko:K02874 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L14 k59_315084_2 702113.PP1Y_AT17033 3.55e-51 162.0 COG0186@1|root,COG0186@2|Bacteria,1MZIK@1224|Proteobacteria,2UBRF@28211|Alphaproteobacteria,2K5VH@204457|Sphingomonadales 204457|Sphingomonadales J One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA rpsQ - - ko:K02961 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S17 k59_315084_3 1144305.PMI02_02091 6.74e-30 107.0 COG0255@1|root,COG0255@2|Bacteria,1N6PR@1224|Proteobacteria,2UF59@28211|Alphaproteobacteria,2K6RZ@204457|Sphingomonadales 204457|Sphingomonadales J Belongs to the universal ribosomal protein uL29 family rpmC - - ko:K02904 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L29 k59_315084_4 1088721.NSU_0950 5.34e-20 83.2 COG0197@1|root,COG0197@2|Bacteria,1RA0Z@1224|Proteobacteria,2U710@28211|Alphaproteobacteria,2K3Z0@204457|Sphingomonadales 204457|Sphingomonadales J Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs rplP - - ko:K02878 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L16 k59_1667835_1 948565.AFFP02000002_gene1215 4.75e-50 174.0 COG1160@1|root,COG1160@2|Bacteria,1MU9S@1224|Proteobacteria,1RMSF@1236|Gammaproteobacteria,1Y7U7@135625|Pasteurellales 135625|Pasteurellales S GTPase that plays an essential role in the late steps of ribosome biogenesis der - - ko:K03977 - - - - ko00000,ko03009 - - - KH_dom-like,MMR_HSR1 k59_89149_1 111780.Sta7437_2945 3.85e-32 132.0 COG0642@1|root,COG2205@2|Bacteria,1G06C@1117|Cyanobacteria,3VJD5@52604|Pleurocapsales 1117|Cyanobacteria T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - HATPase_c,HisKA,Response_reg k59_1102133_1 392499.Swit_1693 5.76e-144 415.0 COG4948@1|root,COG4948@2|Bacteria,1MURK@1224|Proteobacteria,2TV84@28211|Alphaproteobacteria,2JZUU@204457|Sphingomonadales 204457|Sphingomonadales M Belongs to the mandelate racemase muconate lactonizing enzyme family - GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005975,GO:0008150,GO:0008152,GO:0008927,GO:0009056,GO:0016052,GO:0016829,GO:0016835,GO:0016836,GO:0043167,GO:0043169,GO:0044238,GO:0046872,GO:0071704,GO:1901575 4.2.1.8 ko:K08323 ko00040,ko01100,map00040,map01100 M00061 R05606 RC00543 ko00000,ko00001,ko00002,ko01000 - - - MR_MLE_C,MR_MLE_N k59_762357_1 591158.SSMG_03088 6.34e-30 123.0 COG1529@1|root,COG1529@2|Bacteria,2GIVI@201174|Actinobacteria 201174|Actinobacteria C aldehyde oxidase and xanthine dehydrogenase, a b hammerhead - - 1.2.5.3 ko:K03520 - - R11168 RC02800 ko00000,ko01000 - - - Ald_Xan_dh_C,Ald_Xan_dh_C2 k59_649875_1 1122927.KB895434_gene538 2.71e-22 95.1 COG2207@1|root,COG2207@2|Bacteria,1TS5C@1239|Firmicutes,4HF34@91061|Bacilli,26T8N@186822|Paenibacillaceae 91061|Bacilli K AraC family transcriptional regulator rhaS1 - - - - - - - - - - - AraC_binding,HTH_18,HTH_AraC k59_1160163_1 1207076.ALAT01000089_gene1021 2.41e-08 65.1 COG1231@1|root,COG1231@2|Bacteria,1PN10@1224|Proteobacteria,1SXFP@1236|Gammaproteobacteria,1Z4A9@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria E Flavin containing amine oxidoreductase - - 1.4.3.4 ko:K00274 ko00260,ko00330,ko00340,ko00350,ko00360,ko00380,ko00950,ko00982,ko01100,ko01110,ko04726,ko04728,ko05030,ko05031,ko05034,map00260,map00330,map00340,map00350,map00360,map00380,map00950,map00982,map01100,map01110,map04726,map04728,map05030,map05031,map05034 M00135 R02173,R02382,R02529,R02532,R02613,R02908,R02919,R04025,R04300,R04674,R04890,R04893,R04894,R04907,R04908,R08346,R08347,R08348,R11354 RC00062,RC00160,RC00225,RC00676,RC00807,RC00808,RC01808,RC02226,RC02713 ko00000,ko00001,ko00002,ko01000 - - - Amino_oxidase k59_535347_1 1254432.SCE1572_16030 1.69e-46 163.0 COG0620@1|root,COG0620@2|Bacteria,1MV2Z@1224|Proteobacteria,42NPA@68525|delta/epsilon subdivisions,2WT46@28221|Deltaproteobacteria 28221|Deltaproteobacteria E Cobalamin-independent synthase, Catalytic domain - - 2.1.1.14 ko:K00549 ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230 M00017 R04405,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 - - - Meth_synt_2 k59_424499_1 937777.Deipe_2474 6.09e-08 57.8 COG4454@1|root,COG4454@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - Cupredoxin_1 k59_425448_1 595536.ADVE02000001_gene2292 2.99e-47 166.0 COG2759@1|root,COG2759@2|Bacteria,1MUR8@1224|Proteobacteria,2TRMM@28211|Alphaproteobacteria,36XKU@31993|Methylocystaceae 28211|Alphaproteobacteria F Formate--tetrahydrofolate ligase fhs - 6.3.4.3 ko:K01938 ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200 M00140,M00377 R00943 RC00026,RC00111 ko00000,ko00001,ko00002,ko01000 - - - FTHFS k59_1559879_1 1201290.M902_1459 7.65e-61 201.0 COG1005@1|root,COG1005@2|Bacteria,1MU2R@1224|Proteobacteria,42MMX@68525|delta/epsilon subdivisions,2MSXI@213481|Bdellovibrionales,2WIX8@28221|Deltaproteobacteria 213481|Bdellovibrionales C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone nuoH - 1.6.5.3 ko:K00337 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - NADHdh,PDZ_2 k59_1218716_1 1957.JODX01000001_gene5387 3.62e-29 119.0 COG1215@1|root,COG1215@2|Bacteria,2GJCE@201174|Actinobacteria 201174|Actinobacteria M Glycosyl transferase family 2 - - - - - - - - - - - - Glycos_transf_2 k59_821100_1 498211.CJA_1421 1.74e-18 82.4 COG2801@1|root,COG2801@2|Bacteria,1MVXQ@1224|Proteobacteria,1RR4F@1236|Gammaproteobacteria,1FHA5@10|Cellvibrio 1236|Gammaproteobacteria L hmm pf00665 - - - ko:K07497 - - - - ko00000 - - - HTH_21,rve k59_1441588_1 1144305.PMI02_02110 3.18e-145 435.0 COG3211@1|root,COG3211@2|Bacteria,1MU8T@1224|Proteobacteria,2TRVM@28211|Alphaproteobacteria,2K051@204457|Sphingomonadales 204457|Sphingomonadales S Bacterial protein of unknown function (DUF839) - - - ko:K07093 - - - - ko00000 - - - DUF839 k59_763301_1 316407.85676873 7.41e-38 131.0 COG3647@1|root,COG3647@2|Bacteria,1N7NB@1224|Proteobacteria,1RS4F@1236|Gammaproteobacteria,3XMPA@561|Escherichia 1236|Gammaproteobacteria S Predicted membrane protein (DUF2238) yjdF GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K08984 - - - - ko00000 - - - DUF2238 k59_763301_2 316407.85676872 2.7e-31 119.0 COG2211@1|root,COG2211@2|Bacteria,1MVUM@1224|Proteobacteria,1RP5J@1236|Gammaproteobacteria,3XQX4@561|Escherichia 1236|Gammaproteobacteria P Responsible for melibiose and other galactoside transport. It is capable of using hydrogen, sodium, and lithium cations as coupling cations for cotransport, depending on the particular sugar transported (symport system) melB GO:0003674,GO:0005215,GO:0005402,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006814,GO:0008150,GO:0008324,GO:0008643,GO:0015075,GO:0015077,GO:0015081,GO:0015144,GO:0015154,GO:0015156,GO:0015157,GO:0015291,GO:0015293,GO:0015294,GO:0015318,GO:0015370,GO:0015487,GO:0015592,GO:0015672,GO:0015765,GO:0015766,GO:0015769,GO:0015772,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0022890,GO:0030001,GO:0031224,GO:0031226,GO:0034219,GO:0034220,GO:0035725,GO:0043887,GO:0044425,GO:0044459,GO:0044464,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:1901264,GO:1901505,GO:1901656 - ko:K03292,ko:K11104,ko:K16139 - - - - ko00000,ko02000 2.A.2,2.A.2.1 - iBWG_1329.BWG_3833,iECDH10B_1368.ECDH10B_4312,iECDH1ME8569_1439.ECDH1ME8569_3979,iEKO11_1354.EKO11_4199,iEcDH1_1363.EcDH1_3872 MFS_2 k59_1502810_1 288000.BBta_1933 2.79e-13 76.3 COG1073@1|root,COG1073@2|Bacteria,1MXJ3@1224|Proteobacteria,2TVHP@28211|Alphaproteobacteria,3JQQG@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S hydrolases or acyltransferases, alpha beta hydrolase superfamily - - - - - - - - - - - - Abhydrolase_6,DUF1100,Peptidase_S9 k59_1779180_1 391587.KAOT1_04520 2.78e-79 241.0 COG0778@1|root,COG0778@2|Bacteria,4NF4K@976|Bacteroidetes,1HY0I@117743|Flavobacteriia 976|Bacteroidetes C nitroreductase - - - - - - - - - - - - Nitroreductase k59_1779180_2 1121912.AUHD01000004_gene2029 5.6e-11 61.6 COG0399@1|root,COG0399@2|Bacteria,4NG9W@976|Bacteroidetes,1HZDU@117743|Flavobacteriia 976|Bacteroidetes E Belongs to the DegT DnrJ EryC1 family - - 2.6.1.109 ko:K19715 - - R11395 RC00160 ko00000,ko01000,ko01005 - - - DegT_DnrJ_EryC1 k59_1161451_1 1209072.ALBT01000009_gene3073 1.24e-149 430.0 COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,1RN5B@1236|Gammaproteobacteria,1FGFA@10|Cellvibrio 1236|Gammaproteobacteria E DegT/DnrJ/EryC1/StrS aminotransferase family alaA GO:0003674,GO:0003824,GO:0004021,GO:0005488,GO:0006082,GO:0006090,GO:0006520,GO:0006522,GO:0006523,GO:0006807,GO:0006950,GO:0006974,GO:0008144,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009058,GO:0009078,GO:0009079,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0019272,GO:0019752,GO:0019842,GO:0030170,GO:0030632,GO:0032787,GO:0033554,GO:0036094,GO:0042221,GO:0042851,GO:0042852,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046144,GO:0046145,GO:0046394,GO:0046416,GO:0046436,GO:0046437,GO:0046677,GO:0047635,GO:0048037,GO:0050662,GO:0050896,GO:0051716,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.6.1.2,2.6.1.66 ko:K14260 ko00220,ko00250,ko00290,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00290,map01100,map01110,map01130,map01210,map01230 - R00258,R01215 RC00006,RC00008,RC00036 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_1_2 k59_1218728_1 1167006.UWK_02593 5.72e-75 228.0 COG0440@1|root,COG0440@2|Bacteria,1RAGN@1224|Proteobacteria,42RRU@68525|delta/epsilon subdivisions,2WNBY@28221|Deltaproteobacteria,2MJMK@213118|Desulfobacterales 28221|Deltaproteobacteria E TIGRFAM acetolactate synthase, small subunit ilvN - 2.2.1.6 ko:K01653 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - ACT,ACT_5,ALS_ss_C k59_1389709_1 13690.CP98_04526 7.98e-25 105.0 COG1216@1|root,COG1216@2|Bacteria,1R5GW@1224|Proteobacteria,2TTEN@28211|Alphaproteobacteria,2K3YZ@204457|Sphingomonadales 204457|Sphingomonadales S Glycosyltransferase like family 2 - - - - - - - - - - - - Glyco_tranf_2_3,Glycos_transf_2 k59_1328788_1 1175306.GWL_03730 1.45e-19 86.7 COG0654@1|root,COG0654@2|Bacteria,1MWWT@1224|Proteobacteria,2VKZ4@28216|Betaproteobacteria 28216|Betaproteobacteria CH 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases xlnD_2 - 1.14.13.1 ko:K00480 ko00621,ko00624,ko00626,ko01100,ko01120,ko01220,map00621,map00624,map00626,map01100,map01120,map01220 - R00818,R05632,R06915,R06936,R06939 RC00389 ko00000,ko00001,ko01000 - - - FAD_binding_3 k59_1328788_2 864051.BurJ1DRAFT_2818 7.42e-114 343.0 COG4656@1|root,COG4656@2|Bacteria,1R0TB@1224|Proteobacteria,2WI3R@28216|Betaproteobacteria 28216|Betaproteobacteria C Part of a membrane complex involved in electron transport - - - ko:K13795 - - - - ko00000 - - - - k59_650895_1 316407.85676861 9.91e-32 122.0 COG0699@1|root,COG0699@2|Bacteria,1N3I9@1224|Proteobacteria,1RSA8@1236|Gammaproteobacteria,3XMJU@561|Escherichia 1236|Gammaproteobacteria S Important for the colocalization of sister nascent DNA strands after replication fork passage during DNA replication, and for positioning and subsequent partitioning of sister chromosomes. Does not have GTPase activity on its own yjdA GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0007059,GO:0008150,GO:0009987,GO:0044424,GO:0044444,GO:0044464 - - - - - - - - - - Dynamin_N k59_373138_1 1380600.AUYN01000009_gene1026 4.81e-158 468.0 COG0249@1|root,COG0249@2|Bacteria,4NEGB@976|Bacteroidetes,1HX43@117743|Flavobacteriia 976|Bacteroidetes L that it carries out the mismatch recognition step. This protein has a weak ATPase activity mutS GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - ko:K03555 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V k59_933264_1 1121930.AQXG01000001_gene1531 8.79e-107 322.0 COG2211@1|root,COG2211@2|Bacteria,4NE3F@976|Bacteroidetes,1IPIA@117747|Sphingobacteriia 976|Bacteroidetes G Major Facilitator - - - ko:K16211 - - - - ko00000,ko02000 2.A.2.6 - - MFS_1 k59_1779189_1 1254432.SCE1572_27670 1.82e-74 246.0 COG1185@1|root,COG1185@2|Bacteria,1MVB9@1224|Proteobacteria,42MTZ@68525|delta/epsilon subdivisions,2WJCE@28221|Deltaproteobacteria,2YUER@29|Myxococcales 28221|Deltaproteobacteria J Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction pnp GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004654,GO:0005488,GO:0006139,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009892,GO:0009987,GO:0010468,GO:0010605,GO:0010629,GO:0016070,GO:0016071,GO:0016740,GO:0016772,GO:0016779,GO:0019222,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0060255,GO:0065007,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901361,GO:1901363,GO:1901575 2.7.7.8 ko:K00962 ko00230,ko00240,ko03018,map00230,map00240,map03018 M00394 R00437,R00438,R00439,R00440 RC02795 ko00000,ko00001,ko00002,ko01000,ko03016,ko03019 - - - KH_1,PNPase,RNase_PH,RNase_PH_C,S1 k59_1103169_1 204773.HEAR1431 4.61e-07 50.1 COG3094@1|root,COG3094@2|Bacteria,1MZN6@1224|Proteobacteria,2VUWN@28216|Betaproteobacteria,474VE@75682|Oxalobacteraceae 28216|Betaproteobacteria S Invasion gene expression up-regulator, SirB sirB - - - - - - - - - - - SirB k59_650901_1 452637.Oter_1364 5.71e-90 286.0 COG1874@1|root,COG1874@2|Bacteria,46UPS@74201|Verrucomicrobia,3K991@414999|Opitutae 414999|Opitutae G Glycosyl hydrolases family 35 - - - - - - - - - - - - Glyco_hydro_35 k59_1050582_1 156889.Mmc1_3053 1.19e-52 179.0 COG3385@1|root,COG3385@2|Bacteria,1QT8J@1224|Proteobacteria 1224|Proteobacteria L Transposase - - - - - - - - - - - - DDE_Tnp_1_4 k59_881527_1 452637.Oter_4080 2.87e-43 159.0 COG0348@1|root,COG0348@2|Bacteria,46TZJ@74201|Verrucomicrobia,3K7F6@414999|Opitutae 414999|Opitutae C cytochrome c oxidase - - - - - - - - - - - - Fer4_18,Fer4_5,FixG_C k59_373154_1 1137281.D778_02061 2.22e-88 276.0 COG0793@1|root,COG0793@2|Bacteria,4NEGV@976|Bacteroidetes,1HXSR@117743|Flavobacteriia 976|Bacteroidetes M Belongs to the peptidase S41A family ctp - 3.4.21.102 ko:K03797 - - - - ko00000,ko01000,ko01002 - - - PDZ_2,Peptidase_S41 k59_1161481_1 1248916.ANFY01000003_gene830 1.15e-35 140.0 COG2366@1|root,COG2366@2|Bacteria,1MVMH@1224|Proteobacteria,2TS4D@28211|Alphaproteobacteria,2K4AK@204457|Sphingomonadales 204457|Sphingomonadales E Penicillin amidase - - 3.5.1.11 ko:K01434 ko00311,ko01130,map00311,map01130 - R02170 RC00166,RC00328 ko00000,ko00001,ko01000,ko01002 - - - Penicil_amidase k59_1161481_2 1282360.ABAC460_15075 2.72e-106 320.0 COG1680@1|root,COG1680@2|Bacteria,1P3SQ@1224|Proteobacteria,2TTI5@28211|Alphaproteobacteria,2KGKC@204458|Caulobacterales 204458|Caulobacterales V Beta-lactamase - - - - - - - - - - - - Beta-lactamase k59_1559958_1 929562.Emtol_1639 3.06e-88 273.0 COG2115@1|root,COG2115@2|Bacteria,4NEBQ@976|Bacteroidetes,47K9A@768503|Cytophagia 976|Bacteroidetes G Belongs to the xylose isomerase family xylA - 5.3.1.5 ko:K01805 ko00040,ko00051,ko01100,map00040,map00051,map01100 - R00878,R01432 RC00376,RC00516 ko00000,ko00001,ko01000 - - - - k59_650914_1 158500.BV97_02931 1.3e-71 237.0 COG3119@1|root,COG3119@2|Bacteria,1MV92@1224|Proteobacteria,2TTXG@28211|Alphaproteobacteria,2K2F0@204457|Sphingomonadales 204457|Sphingomonadales P PFAM Sulfatase - - 3.1.6.1 ko:K01130 ko00140,ko00600,map00140,map00600 - R03980,R04856 RC00128,RC00231 ko00000,ko00001,ko01000 - - - Sulfatase k59_933289_1 685778.AORL01000010_gene2793 5.4e-17 78.6 COG0812@1|root,COG0812@2|Bacteria,1MXDH@1224|Proteobacteria,2TRQR@28211|Alphaproteobacteria,2K0QA@204457|Sphingomonadales 204457|Sphingomonadales M Cell wall formation murB - 1.3.1.98 ko:K00075 ko00520,ko00550,ko01100,map00520,map00550,map01100 - R03191,R03192 RC02639 ko00000,ko00001,ko01000,ko01011 - - - FAD_binding_4,MurB_C k59_933289_2 702113.PP1Y_AT7463 6.62e-94 288.0 COG0773@1|root,COG0773@2|Bacteria,1MV68@1224|Proteobacteria,2TRT0@28211|Alphaproteobacteria,2K03S@204457|Sphingomonadales 204457|Sphingomonadales M Belongs to the MurCDEF family murC - 6.3.2.8 ko:K01924 ko00471,ko00550,ko01100,map00471,map00550,map01100 - R03193 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_763340_1 1122137.AQXF01000004_gene1425 1.23e-109 323.0 COG0181@1|root,COG0181@2|Bacteria,1MU56@1224|Proteobacteria,2TS3D@28211|Alphaproteobacteria 28211|Alphaproteobacteria H Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps hemC - 2.5.1.61 ko:K01749 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R00084 RC02317 ko00000,ko00001,ko00002,ko01000 - - - Porphobil_deam,Porphobil_deamC k59_763340_2 1122137.AQXF01000004_gene1424 1.32e-26 106.0 COG0533@1|root,COG0533@2|Bacteria,1MU6S@1224|Proteobacteria,2TSF7@28211|Alphaproteobacteria 28211|Alphaproteobacteria J Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction tsaD GO:0000408,GO:0002949,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006508,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0019538,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:1901360,GO:1901564 2.3.1.234 ko:K01409 - - R10648 RC00070,RC00416 ko00000,ko01000,ko03016 - - - Peptidase_M22 k59_90072_1 1122137.AQXF01000001_gene3154 5.44e-114 333.0 COG5429@1|root,COG5429@2|Bacteria,1MW6R@1224|Proteobacteria,2U33F@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Secreted protein MA20_43790 - - - - - - - - - - - DUF1223 k59_821165_1 436308.Nmar_1293 2.92e-108 321.0 COG0119@1|root,arCOG02092@2157|Archaea,41S7Y@651137|Thaumarchaeota 651137|Thaumarchaeota E HMGL-like - - 2.3.3.13 ko:K01649 ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230 M00432 R01213 RC00004,RC00470,RC02754 br01601,ko00000,ko00001,ko00002,ko01000 - - - HMGL-like k59_1441654_1 1207063.P24_10765 3.77e-63 201.0 COG0854@1|root,COG0854@2|Bacteria,1MU9W@1224|Proteobacteria,2TTTF@28211|Alphaproteobacteria,2JPM4@204441|Rhodospirillales 204441|Rhodospirillales H Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate pdxJ - 2.6.99.2 ko:K03474 ko00750,ko01100,map00750,map01100 M00124 R05838 RC01476 ko00000,ko00001,ko00002,ko01000 - - - PdxJ k59_1441654_2 1122963.AUHB01000003_gene3909 5.03e-07 48.9 COG0736@1|root,COG0736@2|Bacteria,1MZBF@1224|Proteobacteria,2U77S@28211|Alphaproteobacteria,36YC3@31993|Methylocystaceae 28211|Alphaproteobacteria I 4'-phosphopantetheinyl transferase superfamily acpS - 2.7.8.7 ko:K00997 ko00770,map00770 - R01625 RC00002 ko00000,ko00001,ko01000 - - - ACPS k59_1559994_1 247633.GP2143_07274 3.15e-06 52.0 COG0614@1|root,COG0614@2|Bacteria,1MWVF@1224|Proteobacteria,1RMV8@1236|Gammaproteobacteria,1J651@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P COG0614 ABC-type Fe3 -hydroxamate transport system, periplasmic component btuF GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0006810,GO:0008144,GO:0008150,GO:0015889,GO:0015893,GO:0019842,GO:0030288,GO:0030313,GO:0031419,GO:0031975,GO:0036094,GO:0042221,GO:0042493,GO:0042597,GO:0044464,GO:0046906,GO:0048037,GO:0050896,GO:0051179,GO:0051180,GO:0051181,GO:0051234,GO:0071702,GO:0071705,GO:0097159,GO:1901363 - ko:K02016,ko:K06858 ko02010,map02010 M00240,M00241 - - ko00000,ko00001,ko00002,ko02000 3.A.1.13,3.A.1.14 - iECH74115_1262.ECH74115_0168,iECSP_1301.ECSP_0159,iECs_1301.ECs0162,iZ_1308.Z0169 Peripla_BP_2 k59_1559994_2 1485545.JQLW01000006_gene308 1e-23 99.4 COG1492@1|root,COG1492@2|Bacteria,1MUFY@1224|Proteobacteria 1224|Proteobacteria H Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation cobQ GO:0003674,GO:0003824,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009235,GO:0009236,GO:0009987,GO:0017144,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042364,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.5.10 ko:K02232 ko00860,ko01100,map00860,map01100 M00122 R05225 RC00010,RC01302 ko00000,ko00001,ko00002,ko01000 - - - AAA_26,CbiA,GATase_3 k59_1614146_1 65497.JODV01000007_gene635 5.16e-24 110.0 COG1316@1|root,COG1316@2|Bacteria,2GJJJ@201174|Actinobacteria,4DXB2@85010|Pseudonocardiales 201174|Actinobacteria K PFAM Cell envelope-related transcriptional attenuator lytR2 - - - - - - - - - - - LytR_cpsA_psr k59_33583_1 1117319.PSPO_19261 2.04e-13 77.8 COG2911@1|root,COG2931@1|root,COG3420@1|root,COG3637@1|root,COG5295@1|root,COG2911@2|Bacteria,COG2931@2|Bacteria,COG3420@2|Bacteria,COG3637@2|Bacteria,COG5295@2|Bacteria,1MU7T@1224|Proteobacteria,1RNK8@1236|Gammaproteobacteria,2Q11U@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria MQU COG2931 RTX toxins and related Ca2 -binding proteins - - - - - - - - - - - - Big_3_2,Big_5,Cadherin_3,He_PIG,OMP_b-brl,OmpA_membrane,fn3 k59_90086_1 1163617.SCD_n02190 1.77e-56 182.0 COG0518@1|root,COG0518@2|Bacteria,1MUDH@1224|Proteobacteria,2VJEI@28216|Betaproteobacteria 28216|Betaproteobacteria F PFAM Glutamine amidotransferase class-I - - 6.3.5.2 ko:K01951 ko00230,ko00983,ko01100,map00230,map00983,map01100 M00050 R01230,R01231,R08244 RC00010,RC00204 ko00000,ko00001,ko00002,ko01000,ko01002 - - - GATase k59_90086_2 666681.M301_0611 0.000676 42.4 COG3577@1|root,COG3577@2|Bacteria,1N2PE@1224|Proteobacteria,2VS6Z@28216|Betaproteobacteria,2KMNB@206350|Nitrosomonadales 206350|Nitrosomonadales S gag-polyprotein putative aspartyl protease - - - ko:K06985 ko04112,map04112 - - - ko00000,ko00001 - - - gag-asp_proteas k59_763360_1 1396141.BATP01000058_gene1988 6.49e-08 56.2 COG0665@1|root,COG0665@2|Bacteria,46ZMA@74201|Verrucomicrobia,2IVR4@203494|Verrucomicrobiae 203494|Verrucomicrobiae E FAD dependent oxidoreductase - - - - - - - - - - - - DAO k59_763360_2 1089550.ATTH01000001_gene296 1.31e-82 259.0 COG0733@1|root,COG0733@2|Bacteria,4P0HG@976|Bacteroidetes,1FJSG@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes S Sodium:neurotransmitter symporter family - - - ko:K03308 - - - - ko00000 2.A.22.4,2.A.22.5 - - SNF k59_1668917_1 1096930.L284_03275 2.91e-96 290.0 COG0484@1|root,COG0484@2|Bacteria,1MVMS@1224|Proteobacteria,2TRZ1@28211|Alphaproteobacteria,2K1EY@204457|Sphingomonadales 204457|Sphingomonadales O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins dnaJ - - ko:K03686 - - - - ko00000,ko03029,ko03110 - - - DnaJ,DnaJ_C,DnaJ_CXXCXGXG k59_1389802_2 436308.Nmar_0430 2.99e-132 378.0 COG1500@1|root,arCOG04187@2157|Archaea,41SC7@651137|Thaumarchaeota 651137|Thaumarchaeota J Shwachman-Bodian-Diamond syndrome (SBDS) protein - - - ko:K14574 ko03008,map03008 - - - ko00000,ko00001,ko03009 - - - SBDS,SBDS_C k59_481045_1 199310.c1090 2.46e-22 90.9 COG0764@1|root,COG0764@2|Bacteria,1MWV8@1224|Proteobacteria,1RP6W@1236|Gammaproteobacteria,3XMG8@561|Escherichia 1236|Gammaproteobacteria I Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length fabA GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0008693,GO:0009058,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016860,GO:0016863,GO:0019171,GO:0019752,GO:0032787,GO:0034017,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0047451,GO:0071704,GO:0072330,GO:1901576 4.2.1.59,5.3.3.14 ko:K01716 ko00061,ko01100,ko01212,map00061,map01100,map01212 M00083 R04428,R04535,R04537,R04544,R04568,R04954,R04965,R07639 RC00831,RC01078,RC01095 ko00000,ko00001,ko00002,ko01000,ko01004 - - iAF1260.b0954,iB21_1397.B21_00965,iBWG_1329.BWG_0806,iE2348C_1286.E2348C_0940,iEC042_1314.EC042_1039,iECBD_1354.ECBD_2641,iECB_1328.ECB_00958,iECDH10B_1368.ECDH10B_1024,iECD_1391.ECD_00958,iECED1_1282.ECED1_0977,iECH74115_1262.ECH74115_1118,iECIAI1_1343.ECIAI1_0995,iECIAI39_1322.ECIAI39_2193,iECNA114_1301.ECNA114_1032,iECO103_1326.ECO103_1000,iECO111_1330.ECO111_1022,iECO26_1355.ECO26_1081,iECOK1_1307.ECOK1_1013,iECS88_1305.ECS88_0975,iECSF_1327.ECSF_0868,iECSP_1301.ECSP_1060,iECUMN_1333.ECUMN_1143,iECW_1372.ECW_m1064,iECs_1301.ECs1038,iEKO11_1354.EKO11_2876,iETEC_1333.ETEC_1024,iEcE24377_1341.EcE24377A_1068,iEcHS_1320.EcHS_A1063,iEcSMS35_1347.EcSMS35_2166,iEcolC_1368.EcolC_2642,iG2583_1286.G2583_1189,iJO1366.b0954,iJR904.b0954,iLF82_1304.LF82_0604,iSBO_1134.SBO_2277,iSDY_1059.SDY_0927,iSF_1195.SF0954,iSSON_1240.SSON_0958,iSbBS512_1146.SbBS512_E2362,iUMNK88_1353.UMNK88_1108,iWFL_1372.ECW_m1064,iY75_1357.Y75_RS04955,iZ_1308.Z1304,ic_1306.c1090 FabA k59_481045_2 316407.85674799 1.52e-170 489.0 COG1067@1|root,COG1067@2|Bacteria,1MWGB@1224|Proteobacteria,1RMPC@1236|Gammaproteobacteria,3XNXW@561|Escherichia 1236|Gammaproteobacteria O Belongs to the peptidase S16 family ycbZ - - ko:K04770 - - - - ko00000,ko01000,ko01002 - - - AAA_32,Lon_C k59_597988_1 342610.Patl_3901 8.02e-06 53.9 COG1629@1|root,COG4206@1|root,COG1629@2|Bacteria,COG4206@2|Bacteria,1QZ7Y@1224|Proteobacteria,1T418@1236|Gammaproteobacteria 1236|Gammaproteobacteria HP TonB dependent receptor - - - - - - - - - - - - Plug,TonB_dep_Rec k59_1161531_1 1469557.JSWF01000029_gene3317 6.75e-12 63.5 COG0194@1|root,COG0194@2|Bacteria,4NEDG@976|Bacteroidetes,1HXN2@117743|Flavobacteriia 976|Bacteroidetes F Essential for recycling GMP and indirectly, cGMP gmk GO:0003674,GO:0003824,GO:0004385,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009126,GO:0009132,GO:0009135,GO:0009150,GO:0009161,GO:0009165,GO:0009167,GO:0009179,GO:0009185,GO:0009259,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0042278,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046037,GO:0046128,GO:0046483,GO:0046710,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901576,GO:1901657 2.7.4.8 ko:K00942 ko00230,ko01100,map00230,map01100 M00050 R00332,R02090 RC00002 ko00000,ko00001,ko00002,ko01000 - - - Guanylate_kin k59_1624976_2 686340.Metal_2805 3.45e-45 149.0 COG1981@1|root,COG1981@2|Bacteria,1RHGS@1224|Proteobacteria,1S5XY@1236|Gammaproteobacteria,1XF45@135618|Methylococcales 135618|Methylococcales S PFAM Uncharacterised protein family (UPF0093) - - - ko:K08973 - - - - ko00000 - - - UPF0093 k59_1402390_1 2850.Phatr20657 6.02e-06 50.8 COG0224@1|root,KOG1531@2759|Eukaryota,2XAWJ@2836|Bacillariophyta 2836|Bacillariophyta C ATP synthase - - - ko:K02115 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt k59_1402390_2 1174684.EBMC1_09709 4.1e-15 74.3 COG1595@1|root,COG1595@2|Bacteria,1N3PK@1224|Proteobacteria,2UIGA@28211|Alphaproteobacteria,2KD1I@204457|Sphingomonadales 204457|Sphingomonadales K Belongs to the sigma-70 factor family. ECF subfamily - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 k59_1624980_1 349521.HCH_03195 2.03e-16 79.3 COG2911@1|root,COG3210@1|root,COG2911@2|Bacteria,COG3210@2|Bacteria,1P8N9@1224|Proteobacteria,1SCTK@1236|Gammaproteobacteria 1236|Gammaproteobacteria G Hep Hag repeat protein - - - - - - - - - - - - Cadherin,DUF4347,DUF5122,He_PIG,OmpA_membrane k59_1514926_1 500635.MITSMUL_04534 1.43e-08 56.2 COG0517@1|root,COG0517@2|Bacteria,1V0XU@1239|Firmicutes,4H33K@909932|Negativicutes 909932|Negativicutes S CBS domain acuB - - ko:K04767 - - - - ko00000 - - - ACT,CBS k59_1514926_2 1229909.NSED_02900 2.24e-48 157.0 COG0432@1|root,arCOG04214@2157|Archaea 2157|Archaea S PFAM Uncharacterised protein family UPF0047 - - - - - - - - - - - - UPF0047 k59_1402411_1 1229909.NSED_09215 7.3e-87 266.0 COG0075@1|root,arCOG00082@2157|Archaea,41SZZ@651137|Thaumarchaeota 651137|Thaumarchaeota E Aminotransferase class-V - - - - - - - - - - - - Aminotran_5 k59_1000448_1 637389.Acaty_c1526 3.13e-16 84.7 COG4796@1|root,COG4796@2|Bacteria,1QTT6@1224|Proteobacteria,1RN3Z@1236|Gammaproteobacteria,2NBYZ@225057|Acidithiobacillales 225057|Acidithiobacillales U Secretin and TonB N terminus short domain - - - ko:K02666 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - Secretin,Secretin_N k59_101020_1 857087.Metme_1089 1.58e-50 166.0 COG1028@1|root,COG1028@2|Bacteria,1MU6X@1224|Proteobacteria,1RMBB@1236|Gammaproteobacteria,1XDSR@135618|Methylococcales 135618|Methylococcales IQ 3-oxoacyl-(Acyl-carrier-protein) reductase - - 1.1.1.100 ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 k59_492148_1 1172188.KB911821_gene1224 2.99e-89 279.0 COG1012@1|root,COG1012@2|Bacteria,2GIWZ@201174|Actinobacteria,4FFAD@85021|Intrasporangiaceae 201174|Actinobacteria C Aldehyde dehydrogenase family calB - 1.2.1.3,1.2.99.10 ko:K00128,ko:K22445 ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130 M00135 R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146 RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_893830_1 1280947.HY30_04505 1.69e-05 54.3 COG4773@1|root,COG4773@2|Bacteria,1QTXJ@1224|Proteobacteria,2U0KK@28211|Alphaproteobacteria 28211|Alphaproteobacteria P Outer membrane receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_547575_1 1267533.KB906734_gene4426 1.73e-11 70.5 COG2271@1|root,COG2271@2|Bacteria,3Y5MH@57723|Acidobacteria 57723|Acidobacteria G PFAM Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 k59_1114417_1 1122137.AQXF01000002_gene57 1.03e-192 539.0 COG0113@1|root,COG0113@2|Bacteria,1MWMW@1224|Proteobacteria,2TS3F@28211|Alphaproteobacteria 28211|Alphaproteobacteria H Belongs to the ALAD family hemB GO:0003674,GO:0003824,GO:0004655,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009987,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.2.1.24 ko:K01698 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R00036 RC00918,RC01781 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ALAD k59_662725_1 926562.Oweho_0727 4.97e-12 70.9 2EGAR@1|root,33A2K@2|Bacteria,4P8IZ@976|Bacteroidetes 976|Bacteroidetes - - - - - - - - - - - - - - - k59_1453219_1 760192.Halhy_4467 3.87e-38 140.0 COG4221@1|root,COG4221@2|Bacteria,4NJF6@976|Bacteroidetes,1IYIM@117747|Sphingobacteriia 976|Bacteroidetes S KR domain acdS - - - - - - - - - - - adh_short k59_893843_1 558152.IQ37_12030 6.04e-05 46.6 2DXXW@1|root,34750@2|Bacteria,4P5I4@976|Bacteroidetes 976|Bacteroidetes - - - - - - - - - - - - - - - k59_1229197_2 266834.SMc01740 8.25e-45 157.0 COG1304@1|root,COG1304@2|Bacteria,1MUEZ@1224|Proteobacteria,2TQNW@28211|Alphaproteobacteria,4B8SA@82115|Rhizobiaceae 28211|Alphaproteobacteria C L-lactate dehydrogenase - - 1.1.2.3,1.1.99.31 ko:K00101,ko:K15054 ko00620,ko00627,ko01100,ko01120,map00620,map00627,map01100,map01120 - R00196,R04160,R07664 RC00044,RC00240 ko00000,ko00001,ko01000 - - - FMN_dh k59_1402443_1 94624.Bpet4807 4.68e-78 246.0 COG1686@1|root,COG1686@2|Bacteria,1MUU7@1224|Proteobacteria,2VH46@28216|Betaproteobacteria,3T1UE@506|Alcaligenaceae 28216|Betaproteobacteria M Belongs to the peptidase S11 family dacC - 3.4.16.4 ko:K07258 ko00550,ko01100,map00550,map01100 - - - ko00000,ko00001,ko01000,ko01002,ko01011 - - - PBP5_C,Peptidase_S11 k59_1680086_1 330214.NIDE1026 3.26e-66 207.0 COG3901@1|root,COG3901@2|Bacteria 2|Bacteria CK FMN binding nosR - - ko:K19339,ko:K19343 - - - - ko00000,ko03000 - - - FMN_bind,Fer4_5 k59_1283416_1 511.JT27_04615 2.21e-84 269.0 COG4770@1|root,COG4770@2|Bacteria,1P6RE@1224|Proteobacteria,2VH59@28216|Betaproteobacteria,3T32G@506|Alcaligenaceae 28216|Betaproteobacteria I carboxylase accA1 GO:0003674,GO:0003824,GO:0004075,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0016053,GO:0016874,GO:0016879,GO:0019216,GO:0019217,GO:0019222,GO:0019752,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032787,GO:0042304,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046394,GO:0046890,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051055,GO:0062012,GO:0062014,GO:0065007,GO:0071704,GO:0072330,GO:0080090,GO:1901576 6.4.1.4 ko:K01968 ko00280,ko01100,map00280,map01100 M00036 R04138 RC00367,RC00942 ko00000,ko00001,ko00002,ko01000 - - - Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2 k59_1737426_1 1492922.GY26_18785 2.65e-87 264.0 COG0179@1|root,COG0179@2|Bacteria,1MUPF@1224|Proteobacteria,1RPYA@1236|Gammaproteobacteria,1J7R7@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria Q Fumarylacetoacetate (FAA) hydrolase family - - 4.3.2.3 ko:K16856 ko00230,ko01100,map00230,map01100 - R00776 RC00153,RC00379 ko00000,ko00001,ko01000 - - - FAA_hydrolase k59_1283423_2 340.xcc-b100_0722 1.15e-12 71.6 COG3284@1|root,COG3284@2|Bacteria,1NRG5@1224|Proteobacteria,1RQMR@1236|Gammaproteobacteria,1X4UD@135614|Xanthomonadales 135614|Xanthomonadales KQ Bacterial regulatory protein, Fis family acoR - - ko:K21405 - - - - ko00000,ko03000 - - - GAF,HTH_8,Sigma54_activat k59_212718_1 420324.KI911961_gene1908 0.000566 45.1 COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,2TQQJ@28211|Alphaproteobacteria,1JRWU@119045|Methylobacteriaceae 28211|Alphaproteobacteria E ATPase component of ABC-type sugar transporter - - - ko:K10112 ko02010,map02010 M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1 - - ABC_tran,TOBE_2 k59_1453247_1 1121380.JNIW01000016_gene2522 5.64e-12 70.9 COG1527@1|root,COG1527@2|Bacteria,1WIV8@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus C Produces ATP from ADP in the presence of a proton gradient across the membrane atpC - - ko:K02119 ko00190,ko01100,map00190,map01100 M00159 - - ko00000,ko00001,ko00002 3.A.2.2,3.A.2.3 - - vATP-synt_AC39 k59_662748_1 745718.JADT01000002_gene2364 1.98e-122 375.0 COG2352@1|root,COG2352@2|Bacteria,4NFC0@976|Bacteroidetes,1HWZI@117743|Flavobacteriia 976|Bacteroidetes C Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle ppc - 4.1.1.31 ko:K01595 ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200 M00168,M00170,M00171,M00172,M00173,M00346,M00374 R00345 RC02741 ko00000,ko00001,ko00002,ko01000 - - - PEPcase k59_436489_1 1229909.NSED_05665 1.07e-13 67.0 arCOG05491@1|root,arCOG05491@2157|Archaea,41SVB@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_436489_2 436308.Nmar_0980 2.39e-140 406.0 COG0012@1|root,arCOG00357@2157|Archaea,41S8X@651137|Thaumarchaeota 651137|Thaumarchaeota J GTPase of unknown function C-terminal - - - ko:K06942 - - - - ko00000,ko03009 - - - MMR_HSR1,MMR_HSR1_C,TGS k59_1453254_1 326298.Suden_1584 2.24e-61 209.0 COG3391@1|root,COG3391@2|Bacteria,1QYKD@1224|Proteobacteria,43E97@68525|delta/epsilon subdivisions,2YSSS@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Cytochrome c554 and c-prime - - - - - - - - - - - - Cytochrome_C554 k59_45162_1 994479.GL877878_gene1911 7.34e-31 120.0 COG3842@1|root,COG3842@2|Bacteria,2GJCM@201174|Actinobacteria,4DY7I@85010|Pseudonocardiales 201174|Actinobacteria E Belongs to the ABC transporter superfamily sugC GO:0006810,GO:0008150,GO:0008643,GO:0009405,GO:0015766,GO:0015771,GO:0015772,GO:0040007,GO:0044110,GO:0044116,GO:0044117,GO:0044403,GO:0044419,GO:0051179,GO:0051234,GO:0051704,GO:0071702 - ko:K10112 ko02010,map02010 M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1 - - ABC_tran,TOBE_2 k59_45162_2 1232410.KI421424_gene1744 1.58e-06 49.3 COG0395@1|root,COG0395@2|Bacteria 2|Bacteria P glycerophosphodiester transmembrane transport - - - ko:K02026 - M00207 - - ko00000,ko00002,ko02000 3.A.1.1 - - BPD_transp_1 k59_212729_2 497321.C664_00315 2.67e-81 259.0 COG1232@1|root,COG1232@2|Bacteria,1NQUH@1224|Proteobacteria,2VJV1@28216|Betaproteobacteria,2KVAB@206389|Rhodocyclales 206389|Rhodocyclales H squalene-associated FAD-dependent desaturase - - - - - - - - - - - - Amino_oxidase k59_1680124_1 582402.Hbal_1504 1.05e-32 124.0 COG0066@1|root,COG0066@2|Bacteria,1MVXB@1224|Proteobacteria,2TRRS@28211|Alphaproteobacteria,43W7M@69657|Hyphomonadaceae 28211|Alphaproteobacteria E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate - - 4.2.1.33,4.2.1.35 ko:K01704 ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230 M00432,M00535 R03896,R03898,R03968,R04001,R10170 RC00976,RC00977,RC01041,RC01046,RC03072 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase_C k59_1680124_2 1088721.NSU_3424 3.6e-12 65.9 COG0065@1|root,COG0065@2|Bacteria,1MVYR@1224|Proteobacteria,2TR6K@28211|Alphaproteobacteria,2K0IM@204457|Sphingomonadales 204457|Sphingomonadales E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate - - 4.2.1.33,4.2.1.35 ko:K01703 ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230 M00432,M00535 R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170 RC00497,RC00976,RC00977,RC01041,RC01046,RC03072 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase k59_270623_1 1443665.JACA01000065_gene4001 5.84e-23 97.1 COG0791@1|root,COG0791@2|Bacteria,4NPFE@976|Bacteroidetes,1I26J@117743|Flavobacteriia,2YJWG@290174|Aquimarina 976|Bacteroidetes M CHAP domain - - - - - - - - - - - - CHAP k59_893897_1 199310.c0692 1.15e-93 278.0 COG1651@1|root,COG1651@2|Bacteria,1NEFD@1224|Proteobacteria,1RQAW@1236|Gammaproteobacteria,3XNA2@561|Escherichia 1236|Gammaproteobacteria O Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process dsbG GO:0003674,GO:0003756,GO:0003824,GO:0005575,GO:0005623,GO:0008150,GO:0008152,GO:0015035,GO:0015036,GO:0016491,GO:0016667,GO:0016853,GO:0016860,GO:0016864,GO:0042597,GO:0044464,GO:0055114,GO:0140096 - ko:K03805 - - - - ko00000,ko03110 - - iECO111_1330.ECO111_0636,iECO26_1355.ECO26_0680,iEcE24377_1341.EcE24377A_0625,iG2583_1286.G2583_0768 Thioredoxin_2 k59_547621_1 1122137.AQXF01000001_gene3001 6.7e-27 112.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,2TQR7@28211|Alphaproteobacteria 28211|Alphaproteobacteria T methyl-accepting chemotaxis protein - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - HAMP,MCPsignal,PilZ,dCache_1 k59_101079_1 1123059.KB823014_gene138 8.13e-72 230.0 2C3QV@1|root,2Z7YP@2|Bacteria,1MXAM@1224|Proteobacteria,2U1FE@28211|Alphaproteobacteria,43WDC@69657|Hyphomonadaceae 28211|Alphaproteobacteria - - - - - - - - - - - - - - Alginate_exp k59_610444_1 1265313.HRUBRA_02707 4.11e-51 171.0 COG5281@1|root,COG5281@2|Bacteria,1NZ1M@1224|Proteobacteria,1S4VY@1236|Gammaproteobacteria,1JAMV@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria D sister chromatid segregation - - - - - - - - - - - - - k59_1680158_1 1278309.KB907107_gene1653 8.78e-34 124.0 COG0030@1|root,COG0030@2|Bacteria,1MVNU@1224|Proteobacteria,1RMHW@1236|Gammaproteobacteria,1XIZA@135619|Oceanospirillales 135619|Oceanospirillales J Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits ksgA - 2.1.1.182 ko:K02528 - - R10716 RC00003,RC03257 ko00000,ko01000,ko03009 - - - RrnaAD k59_1680158_2 1134474.O59_003725 1.5e-39 140.0 COG1995@1|root,COG1995@2|Bacteria,1MX5W@1224|Proteobacteria,1RNZV@1236|Gammaproteobacteria,1FFTZ@10|Cellvibrio 1236|Gammaproteobacteria H Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) pdxA GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006081,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008614,GO:0008615,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0034641,GO:0036094,GO:0042364,GO:0042802,GO:0042816,GO:0042819,GO:0042822,GO:0042823,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046184,GO:0046483,GO:0046872,GO:0046914,GO:0048037,GO:0050570,GO:0050662,GO:0051186,GO:0051188,GO:0051287,GO:0055114,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 1.1.1.262 ko:K00097 ko00750,ko01100,map00750,map01100 M00124 R05681,R05837,R07406 RC00089,RC00675,RC01475 ko00000,ko00001,ko00002,ko01000 - - iECO111_1330.ECO111_0056 PdxA k59_1453304_1 983544.Lacal_2372 3.95e-127 388.0 COG0178@1|root,COG0178@2|Bacteria,4NEHM@976|Bacteroidetes,1HXI7@117743|Flavobacteriia 976|Bacteroidetes L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate uvrA1 - - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - AAA_21,ABC_tran k59_547636_1 1442599.JAAN01000035_gene626 7.88e-126 370.0 COG0473@1|root,COG0473@2|Bacteria,1MUH4@1224|Proteobacteria,1RMZQ@1236|Gammaproteobacteria,1X4UN@135614|Xanthomonadales 135614|Xanthomonadales CE Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate leuB GO:0003674,GO:0003824,GO:0003862,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.85 ko:K00052 ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230 M00432,M00535 R00994,R04426,R10052 RC00084,RC00417,RC03036 br01601,ko00000,ko00001,ko00002,ko01000 - - - Iso_dh k59_1402532_1 187272.Mlg_0982 3.02e-135 406.0 COG1298@1|root,COG1298@2|Bacteria,1MUF3@1224|Proteobacteria,1RMSM@1236|Gammaproteobacteria,1WVWU@135613|Chromatiales 135613|Chromatiales N Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin flhA - - ko:K02400 ko02040,map02040 - - - ko00000,ko00001,ko02035,ko02044 3.A.6.2,3.A.6.3 - - FHIPEP k59_101096_1 1380384.JADN01000004_gene2164 7.79e-79 245.0 COG0665@1|root,COG0665@2|Bacteria,4NEEY@976|Bacteroidetes,1HZ4W@117743|Flavobacteriia 976|Bacteroidetes E Oxidoreductase - - - - - - - - - - - - DAO k59_101096_2 1121912.AUHD01000003_gene3099 7.47e-42 143.0 COG0744@1|root,COG0744@2|Bacteria,4NF90@976|Bacteroidetes,1HXMN@117743|Flavobacteriia 976|Bacteroidetes M Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors mtgA - 2.4.1.129 ko:K03814 ko00550,map00550 - - - ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 - Transgly k59_833264_2 1449347.JQLN01000007_gene1769 6.04e-91 279.0 COG1090@1|root,COG1090@2|Bacteria,2GJS0@201174|Actinobacteria,2M2J5@2063|Kitasatospora 201174|Actinobacteria S Domain of unknown function (DUF1731) - - - ko:K07071 - - - - ko00000 - - - DUF1731,Epimerase k59_1339771_1 994479.GL877879_gene5652 3.75e-64 208.0 COG0473@1|root,COG0473@2|Bacteria,2I8V7@201174|Actinobacteria 201174|Actinobacteria CE Isocitrate isopropylmalate dehydrogenase - - 1.1.1.85 ko:K00052 ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230 M00432,M00535 R00994,R04426,R10052 RC00084,RC00417,RC03036 br01601,ko00000,ko00001,ko00002,ko01000 - - - Iso_dh k59_45230_1 1453498.LG45_05670 9.56e-44 162.0 COG4733@1|root,COG4733@2|Bacteria,4PKY7@976|Bacteroidetes,1IJH4@117743|Flavobacteriia,2P0QU@237|Flavobacterium 976|Bacteroidetes L Metallo-peptidase family M12B Reprolysin-like - - - - - - - - - - - - MAM,Reprolysin_4,fn3 k59_1737475_1 1122137.AQXF01000001_gene3226 8.98e-111 321.0 COG0127@1|root,COG0127@2|Bacteria,1MUK5@1224|Proteobacteria,2TV4B@28211|Alphaproteobacteria 28211|Alphaproteobacteria F Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions rdgB GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009141,GO:0009143,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0055086,GO:0071704,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576 3.6.1.66 ko:K02428 ko00230,map00230 - R00426,R00720,R01855,R02100,R02720,R03531 RC00002 ko00000,ko00001,ko01000 - - - Ham1p_like k59_1229294_2 523791.Kkor_0092 3.33e-58 184.0 COG0789@1|root,COG0789@2|Bacteria,1RGW6@1224|Proteobacteria,1S6HG@1236|Gammaproteobacteria,1XKT1@135619|Oceanospirillales 135619|Oceanospirillales K transcriptional - - - - - - - - - - - - MerR_1 k59_1625093_1 1273103.NM10_04956 1.18e-31 128.0 COG0322@1|root,COG0322@2|Bacteria,1TP4B@1239|Firmicutes,4H2IU@909932|Negativicutes 909932|Negativicutes L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision uvrC - - ko:K03703 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - GIY-YIG,HHH_2,HHH_5,UVR,UvrC_HhH_N k59_1283506_1 1385518.N798_07845 6.68e-64 208.0 COG4974@1|root,COG4974@2|Bacteria,2GNDP@201174|Actinobacteria,4FETP@85021|Intrasporangiaceae 201174|Actinobacteria L recombinase XerD xerD GO:0008150,GO:0040007 - ko:K04763 - - - - ko00000,ko03036 - - - Phage_int_SAM_1,Phage_integrase k59_1061834_1 448385.sce0438 1.89e-124 369.0 COG0031@1|root,COG3620@1|root,COG0031@2|Bacteria,COG3620@2|Bacteria,1MUBE@1224|Proteobacteria,42N1R@68525|delta/epsilon subdivisions,2WJ7R@28221|Deltaproteobacteria,2YTZR@29|Myxococcales 28221|Deltaproteobacteria EK Pyridoxal-phosphate dependent enzyme - - 4.2.1.22 ko:K01697 ko00260,ko00270,ko01100,ko01130,ko01230,map00260,map00270,map01100,map01130,map01230 M00035,M00338 R00891,R01290,R04942 RC00056,RC00069,RC00256,RC00489,RC01246 ko00000,ko00001,ko00002,ko01000 - - - CBS,PALP k59_1402565_1 1217720.ALOX01000076_gene418 2.3e-08 58.5 COG0643@1|root,COG0745@1|root,COG0643@2|Bacteria,COG0745@2|Bacteria,1MUAG@1224|Proteobacteria,2TSN2@28211|Alphaproteobacteria,2JRJI@204441|Rhodospirillales 204441|Rhodospirillales T Two component signalling adaptor domain - - 2.7.13.3 ko:K03407 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 - - - CheW,HATPase_c,Hpt,Response_reg k59_270704_1 1121396.KB893105_gene1813 2.04e-15 80.1 COG0477@1|root,COG2814@2|Bacteria,1QTX0@1224|Proteobacteria,42PT2@68525|delta/epsilon subdivisions,2WJ6Q@28221|Deltaproteobacteria,2MPYF@213118|Desulfobacterales 28221|Deltaproteobacteria EGP Transmembrane secretion effector - - - - - - - - - - - - MFS_3 k59_774407_1 1234364.AMSF01000015_gene3114 1.33e-37 140.0 COG0303@1|root,COG0303@2|Bacteria,1MVD5@1224|Proteobacteria,1RMQU@1236|Gammaproteobacteria,1X5HG@135614|Xanthomonadales 135614|Xanthomonadales H molybdopterin biosynthesis moeA1 - 2.10.1.1 ko:K03750 ko00790,ko01100,map00790,map01100 - R09735 RC03462 ko00000,ko00001,ko01000 - - - MoCF_biosynth,MoeA_C,MoeA_N k59_1789974_1 1122137.AQXF01000003_gene2453 6.49e-97 294.0 COG0489@1|root,COG0489@2|Bacteria,1MU7R@1224|Proteobacteria,2TRDM@28211|Alphaproteobacteria 28211|Alphaproteobacteria D Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP mrp - - ko:K03593 - - - - ko00000,ko03029,ko03036 - - - FeS_assembly_P,ParA k59_1789974_2 1122137.AQXF01000001_gene2661 2.79e-73 227.0 COG0834@1|root,COG0834@2|Bacteria,1MXAY@1224|Proteobacteria,2U4S7@28211|Alphaproteobacteria 28211|Alphaproteobacteria ET Bacterial extracellular solute-binding proteins, family 3 - - - - - - - - - - - - SBP_bac_3 k59_492231_1 4932.YPL283C 2.05e-117 373.0 2CNHI@1|root,2QWCT@2759|Eukaryota,39XTN@33154|Opisthokonta,3NYG1@4751|Fungi,3QNWA@4890|Ascomycota,3RU1R@4891|Saccharomycetes,3RZ5H@4893|Saccharomycetaceae 4751|Fungi A highly expressed in the mutants lacking the telomerase component TLC1 - GO:0000722,GO:0000723,GO:0003674,GO:0003678,GO:0003824,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005739,GO:0006139,GO:0006259,GO:0006310,GO:0006312,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0032200,GO:0032392,GO:0032508,GO:0034641,GO:0042592,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051276,GO:0060249,GO:0065007,GO:0065008,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360 - - - - - - - - - - DEAD,Helicase_C,Sir1 k59_1000583_1 1001585.MDS_0062 0.000394 43.9 COG0454@1|root,COG0456@2|Bacteria,1MZUT@1224|Proteobacteria,1S7GR@1236|Gammaproteobacteria,1YFY2@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria K Acetyltransferase (GNAT) domain ats - - - - - - - - - - - Acetyltransf_1 k59_1000583_2 1122137.AQXF01000003_gene2094 1.76e-55 195.0 COG0823@1|root,COG0823@2|Bacteria,1MWYK@1224|Proteobacteria,2VGDT@28211|Alphaproteobacteria 28211|Alphaproteobacteria U WD40-like Beta Propeller Repeat - - - - - - - - - - - - PD40 k59_893976_1 317619.ANKN01000133_gene3271 6.6e-17 85.5 COG0531@1|root,COG0531@2|Bacteria,1G2VF@1117|Cyanobacteria 1117|Cyanobacteria E PFAM Amino acid permease - - - ko:K03294 - - - - ko00000 2.A.3.2 - - AA_permease_2 k59_1283528_1 1463901.JOIY01000071_gene1456 9.72e-33 128.0 COG1063@1|root,COG1063@2|Bacteria,2GISW@201174|Actinobacteria 201174|Actinobacteria E dehydrogenase - - - ko:K18369 ko00640,map00640 - R10703 RC00545 ko00000,ko00001,ko01000 - - - ADH_N,ADH_N_assoc,ADH_zinc_N k59_944811_1 1237149.C900_00068 1.54e-23 106.0 COG2374@1|root,COG4935@1|root,COG2374@2|Bacteria,COG4935@2|Bacteria,4NHFV@976|Bacteroidetes,47M74@768503|Cytophagia 976|Bacteroidetes M endonuclease I - - - - - - - - - - - - Big_5,CHB_HEX_C_1,Exo_endo_phos k59_1625106_1 1485544.JQKP01000001_gene1248 7.07e-66 214.0 COG0330@1|root,COG0330@2|Bacteria,1MUM2@1224|Proteobacteria,2VIG2@28216|Betaproteobacteria,44VCI@713636|Nitrosomonadales 28216|Betaproteobacteria O HflC and HflK could encode or regulate a protease hflK - - ko:K04088 - M00742 - - ko00000,ko00002,ko01000 - - - Band_7,HflK_N k59_723881_1 1336803.PHEL49_1399 3.59e-69 230.0 COG0591@1|root,COG0591@2|Bacteria,4NEN8@976|Bacteroidetes,1HYVB@117743|Flavobacteriia,3VVMM@52959|Polaribacter 976|Bacteroidetes E Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family yidK - - - - - - - - - - - SSF k59_328823_1 357804.Ping_2217 1.02e-27 102.0 COG0291@1|root,COG0291@2|Bacteria,1N6V4@1224|Proteobacteria,1SCHI@1236|Gammaproteobacteria,2QIDF@267894|Psychromonadaceae 1236|Gammaproteobacteria J Belongs to the bacterial ribosomal protein bL35 family rpmI GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - ko:K02916 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L35p k59_1284855_1 502025.Hoch_4477 2.01e-77 259.0 COG1331@1|root,COG1331@2|Bacteria,1MUUT@1224|Proteobacteria,42MP3@68525|delta/epsilon subdivisions,2WJ7Y@28221|Deltaproteobacteria,2YTWV@29|Myxococcales 28221|Deltaproteobacteria O Protein of unknown function, DUF255 yyaL - - ko:K06888 - - - - ko00000 - - - GlcNAc_2-epim,Thioredox_DsbH k59_156911_1 1121033.AUCF01000011_gene1792 6.75e-100 304.0 COG4239@1|root,COG4239@2|Bacteria,1MUM5@1224|Proteobacteria,2TR1Y@28211|Alphaproteobacteria,2JPAS@204441|Rhodospirillales 204441|Rhodospirillales P transport system, permease component - - - ko:K13895 ko02010,map02010 M00349 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5.21,3.A.1.5.24 - - BPD_transp_1,OppC_N k59_156911_2 794846.AJQU01000078_gene3238 4.56e-41 145.0 COG4174@1|root,COG4174@2|Bacteria,1MVKE@1224|Proteobacteria,2TQJD@28211|Alphaproteobacteria,4B805@82115|Rhizobiaceae 28211|Alphaproteobacteria P ABC transporter yejB GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006857,GO:0008150,GO:0015833,GO:0015893,GO:0016020,GO:0022857,GO:0035672,GO:0042221,GO:0042493,GO:0042884,GO:0042886,GO:0042891,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944 - ko:K13894 ko02010,map02010 M00349 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5.21,3.A.1.5.24 - - BPD_transp_1 k59_1230544_1 1379701.JPJC01000037_gene1574 9.43e-23 105.0 COG4191@1|root,COG5000@1|root,COG4191@2|Bacteria,COG5000@2|Bacteria,1RCM9@1224|Proteobacteria,2TQQ9@28211|Alphaproteobacteria,2K8Y6@204457|Sphingomonadales 204457|Sphingomonadales T Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) - - - - - - - - - - - - HATPase_c,HisKA,PAS_4,Response_reg k59_386755_1 1121440.AUMA01000001_gene53 1.65e-62 218.0 COG1042@1|root,COG1042@2|Bacteria,1MW98@1224|Proteobacteria,42KZW@68525|delta/epsilon subdivisions,2WIQB@28221|Deltaproteobacteria,2M7VR@213115|Desulfovibrionales 28221|Deltaproteobacteria C PFAM CoA-binding domain protein - - 6.2.1.13 ko:K01905,ko:K22224 ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120 - R00229,R00920 RC00004,RC00012,RC00014 ko00000,ko00001,ko01000,ko01004 - - - ATP-grasp_5,CoA_binding_2,Succ_CoA_lig k59_46509_1 1282876.BAOK01000001_gene1673 3.74e-80 250.0 COG4313@1|root,COG4313@2|Bacteria,1MXNW@1224|Proteobacteria,2TV0V@28211|Alphaproteobacteria 28211|Alphaproteobacteria C Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety - - - - - - - - - - - - OMP_b-brl,Phenol_MetA_deg k59_558571_2 330084.JNYZ01000006_gene1231 4.23e-59 192.0 COG1028@1|root,COG1028@2|Bacteria,2GJ1F@201174|Actinobacteria,4E15A@85010|Pseudonocardiales 201174|Actinobacteria IQ Enoyl-(Acyl carrier protein) reductase - GO:0003674,GO:0003824,GO:0004303,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005777,GO:0006066,GO:0006629,GO:0007568,GO:0008150,GO:0008152,GO:0008202,GO:0008203,GO:0009719,GO:0009725,GO:0009987,GO:0010033,GO:0014070,GO:0016125,GO:0016229,GO:0016491,GO:0016614,GO:0016616,GO:0016829,GO:0016835,GO:0016836,GO:0018812,GO:0030283,GO:0032502,GO:0033764,GO:0033993,GO:0042221,GO:0042493,GO:0042579,GO:0042802,GO:0042803,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0044594,GO:0046983,GO:0048545,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0071310,GO:0071407,GO:0071704,GO:1901360,GO:1901615,GO:1902652 - - - - - - - - - - adh_short k59_1011166_1 28258.KP05_12810 1.09e-60 198.0 COG0134@1|root,COG0134@2|Bacteria,1MW5K@1224|Proteobacteria,1RNYH@1236|Gammaproteobacteria,1XIIP@135619|Oceanospirillales 135619|Oceanospirillales E Belongs to the TrpC family trpC - 4.1.1.48,5.3.1.24 ko:K01609,ko:K13498 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R03508,R03509 RC00944,RC00945 ko00000,ko00001,ko00002,ko01000 - - - IGPS k59_844882_1 59196.RICGR_0036 1.08e-49 178.0 COG0326@1|root,COG0326@2|Bacteria,1MUUE@1224|Proteobacteria,1RNWD@1236|Gammaproteobacteria,1JCHY@118969|Legionellales 118969|Legionellales F Molecular chaperone. Has ATPase activity htpG - - ko:K04079 ko04141,ko04151,ko04217,ko04612,ko04621,ko04626,ko04657,ko04659,ko04914,ko04915,ko05200,ko05215,ko05418,map04141,map04151,map04217,map04612,map04621,map04626,map04657,map04659,map04914,map04915,map05200,map05215,map05418 - - - ko00000,ko00001,ko01009,ko03029,ko03051,ko03110,ko04131,ko04147 - - - HATPase_c,HATPase_c_3,HSP90 k59_844882_2 1396418.BATQ01000117_gene4534 3.19e-25 97.4 COG0229@1|root,COG0229@2|Bacteria,46TM8@74201|Verrucomicrobia 74201|Verrucomicrobia O Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine msrA - 1.8.4.11,1.8.4.12 ko:K07305,ko:K12267 - - - - ko00000,ko01000 - - - PMSR,SelR k59_558589_1 1242864.D187_008923 4.87e-52 178.0 COG0657@1|root,COG0657@2|Bacteria,1RGFY@1224|Proteobacteria 1224|Proteobacteria I alpha/beta hydrolase fold - - - - - - - - - - - - Abhydrolase_3 k59_558589_2 551275.KB899544_gene1751 5.73e-60 201.0 COG2303@1|root,COG2303@2|Bacteria,1MU3F@1224|Proteobacteria,2TT3C@28211|Alphaproteobacteria,43XCU@69657|Hyphomonadaceae 28211|Alphaproteobacteria E GMC oxidoreductase - - - - - - - - - - - - FAD_binding_2,GMC_oxred_C,GMC_oxred_N k59_1294904_1 1229909.NSED_09005 3.83e-72 232.0 COG1155@1|root,arCOG00868@2157|Archaea,41SZU@651137|Thaumarchaeota 651137|Thaumarchaeota F Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit atpA - 3.6.3.14,3.6.3.15 ko:K02117 ko00190,ko01100,map00190,map01100 M00159 - - ko00000,ko00001,ko00002,ko01000 3.A.2.2,3.A.2.3 - - ATP-synt_ab,ATP-synt_ab_N,ATP-synt_ab_Xtn k59_955711_1 861299.J421_5906 3.95e-14 76.6 COG0457@1|root,COG0823@1|root,COG0457@2|Bacteria,COG0823@2|Bacteria 2|Bacteria U Involved in the tonB-independent uptake of proteins - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - PD40,Pkinase,WD40 k59_1636188_1 1449049.JONW01000008_gene428 7.63e-78 244.0 COG1960@1|root,COG1960@2|Bacteria,1MW97@1224|Proteobacteria,2TUS1@28211|Alphaproteobacteria 28211|Alphaproteobacteria I acyl-CoA dehydrogenase MA20_38160 - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_2,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_785248_1 1137281.D778_01917 2.1e-75 230.0 COG1788@1|root,COG1788@2|Bacteria,4NF3T@976|Bacteroidetes,1HY5F@117743|Flavobacteriia 976|Bacteroidetes I COG1788 Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit scoA - 2.8.3.5,2.8.3.6,2.8.3.8,2.8.3.9 ko:K01027,ko:K01028,ko:K01031,ko:K01034 ko00072,ko00280,ko00310,ko00362,ko00627,ko00640,ko00650,ko01100,ko01120,ko02020,map00072,map00280,map00310,map00362,map00627,map00640,map00650,map01100,map01120,map02020 - R00410,R01179,R01359,R01365,R02990,R07832 RC00012,RC00014 ko00000,ko00001,ko01000 - - - CoA_trans k59_785248_2 1469557.JSWF01000028_gene2783 2.54e-138 392.0 COG2057@1|root,COG2057@2|Bacteria,4NG9J@976|Bacteroidetes,1HWRK@117743|Flavobacteriia 976|Bacteroidetes I COG2057 Acyl CoA acetate 3-ketoacid CoA transferase, beta subunit scoB - 2.8.3.5,2.8.3.6 ko:K01029,ko:K01032 ko00072,ko00280,ko00362,ko00650,ko01100,ko01120,map00072,map00280,map00362,map00650,map01100,map01120 - R00410,R02990 RC00014 ko00000,ko00001,ko01000 - - - CoA_trans k59_844937_1 198214.SF2931 4.22e-177 509.0 COG1166@1|root,COG1166@2|Bacteria,1MU80@1224|Proteobacteria,1RP2J@1236|Gammaproteobacteria 1236|Gammaproteobacteria H Catalyzes the biosynthesis of agmatine from arginine speA GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006525,GO:0006527,GO:0006576,GO:0006595,GO:0006596,GO:0006807,GO:0008150,GO:0008152,GO:0008792,GO:0009056,GO:0009058,GO:0009063,GO:0009064,GO:0009065,GO:0009308,GO:0009309,GO:0009445,GO:0009446,GO:0009987,GO:0016054,GO:0016829,GO:0016830,GO:0016831,GO:0019752,GO:0034641,GO:0042401,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044271,GO:0044281,GO:0044282,GO:0046395,GO:0071704,GO:0097164,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606 4.1.1.19 ko:K01585 ko00330,ko01100,map00330,map01100 M00133 R00566 RC00299 ko00000,ko00001,ko00002,ko01000 - - iAPECO1_1312.APECO1_3590,iE2348C_1286.E2348C_3191,iEC55989_1330.EC55989_3231,iECABU_c1320.ECABU_c32250,iECED1_1282.ECED1_3401,iECIAI1_1343.ECIAI1_3071,iECIAI39_1322.ECIAI39_3358,iECO103_1326.ECO103_3518,iECO26_1355.ECO26_4037,iECOK1_1307.ECOK1_3327,iECP_1309.ECP_2933,iECS88_1305.ECS88_3221,iECSE_1348.ECSE_3207,iECSF_1327.ECSF_2737,iECSP_1301.ECSP_3909,iECUMN_1333.ECUMN_3290,iECW_1372.ECW_m3198,iECs_1301.ECs3814,iEKO11_1354.EKO11_0788,iEcE24377_1341.EcE24377A_3281,iEcHS_1320.EcHS_A3096,iEcolC_1368.EcolC_0773,iG2583_1286.G2583_3597,iLF82_1304.LF82_2157,iNRG857_1313.NRG857_14440,iPC815.YPO0929,iSBO_1134.SBO_3051,iSDY_1059.SDY_3134,iSSON_1240.SSON_3092,iSbBS512_1146.SbBS512_E3371,iWFL_1372.ECW_m3198,iZ_1308.Z4283 Orn_Arg_deC_N k59_223950_1 1265502.KB905948_gene1025 1.09e-15 80.5 COG2207@1|root,COG2207@2|Bacteria,1MXDJ@1224|Proteobacteria,2VKP6@28216|Betaproteobacteria,4AE1J@80864|Comamonadaceae 28216|Betaproteobacteria K helix_turn_helix, arabinose operon control protein pobR - - ko:K18954 - - - - ko00000,ko03000 - - - AraC_binding,HTH_18 k59_223953_1 327079.R9P1C2 6.59e-26 103.0 COG0106@1|root,KOG3055@2759|Eukaryota,39RKQ@33154|Opisthokonta,3NVJU@4751|Fungi,3UYMU@5204|Basidiomycota,3N4ZC@452284|Ustilaginomycotina 4751|Fungi E Histidine biosynthesis protein HIS6 GO:0000105,GO:0000162,GO:0003674,GO:0003824,GO:0003949,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.3.1.16 ko:K01814 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04640 RC00945 ko00000,ko00001,ko00002,ko01000 - - - His_biosynth k59_223953_2 28072.Nos7524_3479 1.83e-51 174.0 COG1932@1|root,COG1932@2|Bacteria,1G0W3@1117|Cyanobacteria,1HIX0@1161|Nostocales 1117|Cyanobacteria EH Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine - - 2.6.1.52 ko:K00831 ko00260,ko00680,ko00750,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map00750,map01100,map01120,map01130,map01200,map01230 M00020,M00124 R04173,R05085 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_5 k59_447561_1 330214.NIDE3237 1.66e-90 293.0 COG0243@1|root,COG0243@2|Bacteria 2|Bacteria C molybdopterin cofactor binding ddhA GO:0005575,GO:0005623,GO:0042597,GO:0044464 1.17.99.2,1.7.5.1,1.8.2.4 ko:K00370,ko:K10700,ko:K16964,ko:K17050 ko00642,ko00910,ko00920,ko01100,ko01120,ko01220,ko02020,map00642,map00910,map00920,map01100,map01120,map01220,map02020 M00529,M00530,M00804 R00798,R01106,R05745,R09497,R09500 RC00275,RC02555,RC02812 ko00000,ko00001,ko00002,ko01000,ko02000 5.A.3.1,5.A.3.8,5.A.3.9 - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding,TAT_signal k59_1464562_1 203122.Sde_1767 6.72e-98 300.0 COG3534@1|root,COG3534@2|Bacteria,1PPWJ@1224|Proteobacteria,1RQ0J@1236|Gammaproteobacteria,465P4@72275|Alteromonadaceae 1236|Gammaproteobacteria G Alpha-L-arabinofuranosidase C-terminus abfA - 3.2.1.55 ko:K01209 ko00520,map00520 - R01762 - ko00000,ko00001,ko01000 - GH51 - Alpha-L-AF_C k59_955771_1 521674.Plim_1809 5.9e-53 185.0 COG0265@1|root,COG0265@2|Bacteria,2IXA0@203682|Planctomycetes 203682|Planctomycetes O peptidase S1 and S6 chymotrypsin Hap - - - - - - - - - - - - PDZ_2,Trypsin_2 k59_1294954_1 1122207.MUS1_13680 7.57e-14 79.0 2BX7Z@1|root,2ZBYH@2|Bacteria,1RFFM@1224|Proteobacteria,1S5CF@1236|Gammaproteobacteria,1XPRN@135619|Oceanospirillales 135619|Oceanospirillales S F plasmid transfer operon, TraF, protein - - - - - - - - - - - - TraF_2 k59_502744_1 745411.B3C1_11207 4.74e-25 102.0 COG0112@1|root,COG0112@2|Bacteria,1MUIS@1224|Proteobacteria,1RMHQ@1236|Gammaproteobacteria,1J4EX@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism glyA GO:0001505,GO:0003674,GO:0003824,GO:0004372,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006544,GO:0006545,GO:0006546,GO:0006563,GO:0006565,GO:0006730,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008270,GO:0008652,GO:0009056,GO:0009058,GO:0009063,GO:0009069,GO:0009070,GO:0009071,GO:0009987,GO:0016053,GO:0016054,GO:0016740,GO:0016741,GO:0016742,GO:0017144,GO:0019264,GO:0019752,GO:0019842,GO:0030170,GO:0036094,GO:0042133,GO:0042135,GO:0042136,GO:0042737,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046395,GO:0046872,GO:0046914,GO:0048037,GO:0050662,GO:0065007,GO:0065008,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1901607 2.1.2.1 ko:K00600 ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523 M00140,M00141,M00346,M00532 R00945,R09099 RC00022,RC00112,RC01583,RC02958 ko00000,ko00001,ko00002,ko01000 - - iG2583_1286.G2583_3081 SHMT k59_502744_2 626887.J057_14500 3.85e-37 129.0 COG1327@1|root,COG1327@2|Bacteria,1RE7V@1224|Proteobacteria,1S3P9@1236|Gammaproteobacteria,466Q5@72275|Alteromonadaceae 1236|Gammaproteobacteria K Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes nrdR GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0005488,GO:0005524,GO:0006355,GO:0008144,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0017076,GO:0019219,GO:0019222,GO:0030554,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 - ko:K07738 - - - - ko00000,ko03000 - - - ATP-cone k59_1691472_1 1122137.AQXF01000003_gene2433 2.4e-117 344.0 COG2264@1|root,COG2264@2|Bacteria,1MUPC@1224|Proteobacteria,2TTP3@28211|Alphaproteobacteria 28211|Alphaproteobacteria J Ribosomal protein L11 methyltransferase prmA - - ko:K02687 - - - - ko00000,ko01000,ko03009 - - - PrmA k59_558675_1 1049564.TevJSym_bn00220 1.19e-53 182.0 COG1638@1|root,COG1638@2|Bacteria 2|Bacteria G carbohydrate transport - - - ko:K11688,ko:K21395 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.56.1 - - DctP k59_558675_2 1298593.TOL_3420 1.55e-31 117.0 COG3090@1|root,COG3090@2|Bacteria,1MZNX@1224|Proteobacteria,1SD4H@1236|Gammaproteobacteria,1XM5N@135619|Oceanospirillales 135619|Oceanospirillales G TRAP-type C4-dicarboxylate transport system, small permease component - - - - - - - - - - - - DctQ k59_1350824_1 247639.MGP2080_08444 3.58e-48 172.0 COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,1RMZ8@1236|Gammaproteobacteria,1J7SB@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria I 3-hydroxyacyl-coa dehydrogenase fadJ - 1.1.1.35,4.2.1.17,5.1.2.3 ko:K01782 ko00071,ko00280,ko00281,ko00310,ko00362,ko00380,ko00410,ko00640,ko00650,ko00903,ko00930,ko01040,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00362,map00380,map00410,map00640,map00650,map00903,map00930,map01040,map01100,map01110,map01120,map01130,map01200,map01212 M00032,M00087 R01975,R03026,R03045,R03276,R04137,R04170,R04203,R04204,R04224,R04737,R04738,R04739,R04740,R04741,R04744,R04745,R04746,R04748,R04749,R05066,R05305,R06411,R06412,R06941,R06942,R07935,R07951,R08093,R08094 RC00029,RC00099,RC00117,RC00241,RC00525,RC00831,RC00834,RC00896,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 - - - 3HCDH,3HCDH_N,ECH_1 k59_844974_1 426117.M446_2100 7.73e-13 69.3 COG0259@1|root,COG0259@2|Bacteria,1NZUU@1224|Proteobacteria,2TT1U@28211|Alphaproteobacteria,1JSJM@119045|Methylobacteriaceae 28211|Alphaproteobacteria H Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) pdxH GO:0003674,GO:0003824,GO:0004733,GO:0006081,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0016491,GO:0016638,GO:0016641,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0034641,GO:0042364,GO:0042816,GO:0042819,GO:0042822,GO:0042823,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046184,GO:0046483,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 1.4.3.5 ko:K00275 ko00750,ko01100,ko01120,map00750,map01100,map01120 M00124 R00277,R00278,R01710,R01711 RC00048,RC00116 ko00000,ko00001,ko00002,ko01000 - - - PNP_phzG_C,Putative_PNPOx k59_844974_2 83219.PM02_13275 6.54e-05 47.8 COG3063@1|root,COG3063@2|Bacteria,1QV6V@1224|Proteobacteria,2TWBN@28211|Alphaproteobacteria,3ZX5D@60136|Sulfitobacter 28211|Alphaproteobacteria NU Type IV pilus biogenesis stability protein PilW - - - - - - - - - - - - TPR_16,TPR_2,TPR_6 k59_673732_2 1254432.SCE1572_22045 6.52e-49 176.0 2DMMW@1|root,32SIJ@2|Bacteria,1N004@1224|Proteobacteria,42TSJ@68525|delta/epsilon subdivisions,2WQHG@28221|Deltaproteobacteria,2YV84@29|Myxococcales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_673732_3 429009.Adeg_1868 7.23e-12 65.1 COG1521@1|root,COG1521@2|Bacteria,1W6WH@1239|Firmicutes,25MFC@186801|Clostridia,42IST@68295|Thermoanaerobacterales 186801|Clostridia H Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis coaX - 2.7.1.33 ko:K03525 ko00770,ko01100,map00770,map01100 M00120 R02971,R03018,R04391 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - Pan_kinase k59_1294974_1 565045.NOR51B_247 9.38e-66 218.0 COG0457@1|root,COG0457@2|Bacteria,1MVMG@1224|Proteobacteria,1RU5N@1236|Gammaproteobacteria 1236|Gammaproteobacteria K COG0457 FOG TPR repeat - - - - - - - - - - - - Sulfotransfer_3,TPR_16,TPR_19,TPR_8 k59_1691513_1 1121035.AUCH01000022_gene3191 1.64e-84 272.0 COG0204@1|root,COG0318@1|root,COG0204@2|Bacteria,COG0318@2|Bacteria,1MWDY@1224|Proteobacteria,2VK7T@28216|Betaproteobacteria,2KUKS@206389|Rhodocyclales 206389|Rhodocyclales IQ Phosphate acyltransferases - - 2.3.1.40,6.2.1.20 ko:K05939 ko00071,ko00564,map00071,map00564 - R01406,R04864 RC00014,RC00039,RC00041 ko00000,ko00001,ko01000 - - - AMP-binding,Acyltransferase k59_1072757_1 199310.c0090 1.04e-16 78.2 COG0473@1|root,COG0473@2|Bacteria,1MUH4@1224|Proteobacteria,1RMZQ@1236|Gammaproteobacteria,3XNII@561|Escherichia 1236|Gammaproteobacteria CE Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate leuB GO:0000287,GO:0003674,GO:0003824,GO:0003862,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0006950,GO:0007154,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0030145,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0034198,GO:0042594,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0055114,GO:0071496,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1990928 1.1.1.85 ko:K00052 ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230 M00432,M00535 R00994,R04426,R10052 RC00084,RC00417,RC03036 br01601,ko00000,ko00001,ko00002,ko01000 - - iECs_1301.ECs0077,iYL1228.KPN_00079,iZ_1308.Z0082 Iso_dh k59_1072757_2 316407.85674316 9.8e-98 295.0 COG0065@1|root,COG0065@2|Bacteria,1MVYR@1224|Proteobacteria,1RMF6@1236|Gammaproteobacteria,3XN9T@561|Escherichia 1236|Gammaproteobacteria E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate leuC GO:0003674,GO:0003824,GO:0003861,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009316,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016866,GO:0019752,GO:0032991,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494 4.2.1.33,4.2.1.35 ko:K01703 ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230 M00432,M00535 R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170 RC00497,RC00976,RC00977,RC01041,RC01046,RC03072 br01601,ko00000,ko00001,ko00002,ko01000 - - iEcE24377_1341.EcE24377A_0075,iPC815.YPO0531 Aconitase k59_447604_1 1005048.CFU_4378 3.08e-90 280.0 COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2VHGR@28216|Betaproteobacteria,472HD@75682|Oxalobacteraceae 28216|Betaproteobacteria C Belongs to the aldehyde dehydrogenase family gabD - 1.2.1.16,1.2.1.20,1.2.1.79 ko:K00135 ko00250,ko00310,ko00350,ko00650,ko00760,ko01100,ko01120,map00250,map00310,map00350,map00650,map00760,map01100,map01120 M00027 R00713,R00714,R02401 RC00080 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_1184224_1 398527.Bphyt_2906 1.09e-56 181.0 COG1595@1|root,COG1595@2|Bacteria,1MX7T@1224|Proteobacteria,2VHR2@28216|Betaproteobacteria,1K1T9@119060|Burkholderiaceae 28216|Betaproteobacteria K Belongs to the sigma-70 factor family. ECF subfamily rpoE - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 k59_112552_1 298653.Franean1_0298 6.51e-125 377.0 COG0465@1|root,COG0465@2|Bacteria,2GJ4Q@201174|Actinobacteria,4ERQQ@85013|Frankiales 201174|Actinobacteria O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins ftsH GO:0003674,GO:0003824,GO:0004176,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009056,GO:0009057,GO:0010468,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019222,GO:0019538,GO:0030163,GO:0040007,GO:0042623,GO:0043170,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050896,GO:0060255,GO:0065007,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901565,GO:1901575 - ko:K03798 - M00742 - - ko00000,ko00002,ko01000,ko01002,ko03110 - - - AAA,FtsH_ext,Peptidase_M41 k59_282102_1 1123270.ATUR01000006_gene203 5.41e-137 400.0 COG4638@1|root,COG4638@2|Bacteria,1R4IX@1224|Proteobacteria,2U511@28211|Alphaproteobacteria,2K30Q@204457|Sphingomonadales 204457|Sphingomonadales P PFAM Rieske 2Fe-2S domain - - - - - - - - - - - - Rieske,Ring_hydroxyl_A k59_1350860_1 436308.Nmar_0707 5.25e-26 103.0 COG2201@1|root,arCOG02382@2157|Archaea 2157|Archaea NT catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR cheB - 3.1.1.61,3.5.1.44 ko:K03412,ko:K03413 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko02022,ko02035 - - - CheB_methylest,Response_reg k59_1295006_2 1122137.AQXF01000008_gene3443 5.17e-80 259.0 COG4618@1|root,COG4618@2|Bacteria,1NTI5@1224|Proteobacteria,2TR17@28211|Alphaproteobacteria 28211|Alphaproteobacteria V COG4618 ABC-type protease lipase transport system, ATPase and permease components - - - ko:K16299 ko02010,map02010 M00571 - - ko00000,ko00001,ko00002,ko02000,ko02044 3.A.1.110.10 - - ABC_membrane,ABC_tran k59_558722_1 86416.Clopa_4610 3.01e-16 83.2 COG0488@1|root,COG0488@2|Bacteria,1TPAX@1239|Firmicutes,247U6@186801|Clostridia,36ER9@31979|Clostridiaceae 186801|Clostridia S ABC transporter yfmM - - ko:K06158 - - - - ko00000,ko03012 - - - ABC_tran,ABC_tran_Xtn k59_1184268_1 87626.PTD2_22022 1.08e-30 120.0 COG1506@1|root,COG1506@2|Bacteria,1R60J@1224|Proteobacteria,1RS55@1236|Gammaproteobacteria,2Q01P@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria E COG1506 Dipeptidyl aminopeptidases acylaminoacyl-peptidases - - - - - - - - - - - - Peptidase_S9 k59_166925_1 998086.F8SJ76_9CAUD 1.84e-28 122.0 4QAKZ@10239|Viruses,4QYAE@35237|dsDNA viruses no RNA stage,4QPYH@28883|Caudovirales 28883|Caudovirales S N-acetyltransferase activity - - - - - - - - - - - - - k59_1350873_1 1121939.L861_22545 1.01e-57 202.0 COG1201@1|root,COG1201@2|Bacteria,1MUSW@1224|Proteobacteria,1RSNV@1236|Gammaproteobacteria,1XNJ7@135619|Oceanospirillales 135619|Oceanospirillales L DEAD/H associated - - - ko:K03724 - - - - ko00000,ko01000,ko03400 - - - DEAD,DEAD_assoc,Helicase_C k59_502784_1 1122137.AQXF01000001_gene3124 4.99e-09 57.0 COG1502@1|root,COG1502@2|Bacteria,1MWUW@1224|Proteobacteria,2TUW3@28211|Alphaproteobacteria 28211|Alphaproteobacteria I Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol cls - - ko:K06131 ko00564,ko01100,map00564,map01100 - R07390 RC00017 ko00000,ko00001,ko01000 - - - PLDc_2,PLDc_N k59_502784_2 1122137.AQXF01000001_gene3123 5.4e-54 177.0 COG4133@1|root,COG4133@2|Bacteria,1MZPC@1224|Proteobacteria,2TVBT@28211|Alphaproteobacteria 28211|Alphaproteobacteria P once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system ccmA - 3.6.3.41 ko:K02193 ko02010,map02010 M00259 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.107 - - ABC_tran k59_1011306_1 547559.Nmag_2901 5.86e-22 98.2 COG1960@1|root,arCOG01707@2157|Archaea,2XT5S@28890|Euryarchaeota,23SK3@183963|Halobacteria 183963|Halobacteria I COG1960 Acyl-CoA dehydrogenases acdC - 1.3.8.7 ko:K00249 ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320 M00013,M00036,M00087 R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754 RC00052,RC00068,RC00076,RC00095,RC00148,RC00246 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_1466125_1 702113.PP1Y_AT35241 5.04e-134 402.0 COG1674@1|root,COG1674@2|Bacteria,1MVPI@1224|Proteobacteria,2TR48@28211|Alphaproteobacteria,2K02P@204457|Sphingomonadales 204457|Sphingomonadales D DNA segregation ATPase FtsK SpoIIIE ftsK - - ko:K03466 - - - - ko00000,ko03036 3.A.12 - - FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma k59_1466127_2 1123242.JH636435_gene1166 6.21e-29 119.0 COG2755@1|root,COG3119@1|root,COG2755@2|Bacteria,COG3119@2|Bacteria,2IX9T@203682|Planctomycetes 203682|Planctomycetes P COG3119 Arylsulfatase A and related enzymes - - - - - - - - - - - - DUF4976,Sulfatase k59_786859_1 1163617.SCD_n00618 2.28e-43 157.0 COG0085@1|root,COG0085@2|Bacteria,1MUC4@1224|Proteobacteria,2VHF3@28216|Betaproteobacteria 28216|Betaproteobacteria K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoB - 2.7.7.6 ko:K03043 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7 k59_846587_2 1415780.JPOG01000001_gene2678 3.7e-44 157.0 COG4962@1|root,COG4962@2|Bacteria,1R7EN@1224|Proteobacteria,1RP9G@1236|Gammaproteobacteria,1X4ZD@135614|Xanthomonadales 135614|Xanthomonadales U secretion system protein - - - ko:K02283,ko:K20527 ko02024,map02024 - - - ko00000,ko00001,ko02035,ko02044 3.A.7.4 - - FHA,T2SSE k59_225663_1 115417.EPrPW00000013195 2.27e-37 144.0 COG0265@1|root,KOG1421@2759|Eukaryota,1MAFU@121069|Pythiales 121069|Pythiales O Pro-apoptotic serine protease - - - - - - - - - - - - PDZ_1,PDZ_2,Trypsin_2 k59_1012889_1 1280949.HAD_05125 2.74e-78 253.0 COG0405@1|root,COG0405@2|Bacteria,1Q089@1224|Proteobacteria,2U8PM@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Gamma-glutamyltranspeptidase - - 2.3.2.2,3.4.19.13 ko:K00681 ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100 - R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935 RC00064,RC00090,RC00096 ko00000,ko00001,ko01000,ko01002 - - - G_glu_transpept k59_846592_2 314225.ELI_08265 7.25e-21 90.5 COG4961@1|root,COG4961@2|Bacteria,1N654@1224|Proteobacteria,2U9MJ@28211|Alphaproteobacteria,2K5IF@204457|Sphingomonadales 204457|Sphingomonadales U overlaps another CDS with the same product name - - - - - - - - - - - - TadE k59_1637943_2 234267.Acid_3616 5.4e-52 176.0 COG0436@1|root,COG0436@2|Bacteria,3Y2TF@57723|Acidobacteria 57723|Acidobacteria E PFAM aminotransferase, class I - - - ko:K10907 - - - - ko00000,ko01000,ko01007 - - - Aminotran_1_2 k59_504487_1 1122137.AQXF01000003_gene2088 2.35e-111 333.0 COG1228@1|root,COG1228@2|Bacteria,1MVAF@1224|Proteobacteria,2U0BD@28211|Alphaproteobacteria 28211|Alphaproteobacteria Q Amidohydrolase family - - - - - - - - - - - - Amidohydro_1 k59_225678_1 316407.85676514 7.94e-22 93.6 COG0457@1|root,COG3118@1|root,COG0457@2|Bacteria,COG3118@2|Bacteria,1MVB8@1224|Proteobacteria,1RPSN@1236|Gammaproteobacteria,3XMYE@561|Escherichia 1236|Gammaproteobacteria O cellulose synthase operon protein C bcsC - - ko:K20543 - - - - ko00000,ko02000 1.B.55.3 - - BCSC_C,TPR_16,TPR_19,TPR_8 k59_225678_2 199310.c4343 9.3e-160 452.0 COG3405@1|root,COG3405@2|Bacteria,1MW17@1224|Proteobacteria,1RNEU@1236|Gammaproteobacteria,3XP70@561|Escherichia 1236|Gammaproteobacteria G Belongs to the glycosyl hydrolase 8 (cellulase D) family bcsZ GO:0003674,GO:0003824,GO:0004553,GO:0005575,GO:0005576,GO:0008810,GO:0016787,GO:0016798 3.2.1.4 ko:K20542 - - - - ko00000,ko01000 - GH8 - Glyco_hydro_8 k59_957487_1 556268.OFAG_00821 3.24e-100 319.0 COG5525@1|root,COG5525@2|Bacteria,1NE5I@1224|Proteobacteria 1224|Proteobacteria S Phage terminase large subunit (GpA) - - - - - - - - - - - - Terminase_GpA k59_1637953_1 566466.NOR53_3634 2.79e-06 50.4 COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,1RNB5@1236|Gammaproteobacteria,1J52M@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C acyl-CoA transferases carnitine dehydratase caiB - 2.8.3.16 ko:K07749 - - - - ko00000,ko01000 - - - CoA_transf_3 k59_1637953_2 1123073.KB899241_gene2699 1.17e-95 293.0 COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,1RN5B@1236|Gammaproteobacteria,1X32P@135614|Xanthomonadales 135614|Xanthomonadales E aminotransferase - - 2.6.1.2,2.6.1.66 ko:K14260 ko00220,ko00250,ko00290,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00290,map01100,map01110,map01130,map01210,map01230 - R00258,R01215 RC00006,RC00008,RC00036 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_1_2 k59_1637954_1 237609.PSAKL28_25340 8.14e-38 143.0 28HMZ@1|root,2Z7WD@2|Bacteria,1MU3Q@1224|Proteobacteria,1RRUM@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Protein of unknown function (DUF3604) - - - - - - - - - - - - DUF3604 k59_1637954_2 1216007.AOPM01000102_gene745 1.35e-09 58.5 COG0695@1|root,COG0695@2|Bacteria,1N0IY@1224|Proteobacteria,1SA4G@1236|Gammaproteobacteria,2Q2N6@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria O COG0695 Glutaredoxin and related proteins - - - - - - - - - - - - GST_N_3,Glutaredoxin k59_1637955_1 1123487.KB892863_gene1991 3.45e-14 75.5 COG0492@1|root,COG0492@2|Bacteria 2|Bacteria C ferredoxin-NADP+ reductase activity trxB_2 - 1.18.1.2,1.19.1.1,1.8.1.9 ko:K00384,ko:K21567 ko00450,map00450 - R02016,R03596,R09372 RC00013,RC02518,RC02873 ko00000,ko00001,ko01000 - - - Fer4,Fer4_10,Pyr_redox_3 k59_957510_1 196490.AUEZ01000002_gene4196 2.49e-08 54.7 COG1053@1|root,COG1053@2|Bacteria,1MU5M@1224|Proteobacteria,2U1QF@28211|Alphaproteobacteria,3JXWM@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria C Fumarate reductase flavoprotein C-term - - - - - - - - - - - - FAD_binding_2,Succ_DH_flav_C k59_1466178_2 768671.ThimaDRAFT_1867 4.25e-103 310.0 COG1752@1|root,COG1752@2|Bacteria,1MUM9@1224|Proteobacteria,1RRA1@1236|Gammaproteobacteria,1WWUF@135613|Chromatiales 135613|Chromatiales S PFAM Patatin - - - ko:K07001 - - - - ko00000 - - - Patatin k59_1012930_1 1329516.JPST01000014_gene535 1.83e-20 95.9 COG0009@1|root,COG0009@2|Bacteria,1TP1I@1239|Firmicutes,4HA7W@91061|Bacilli,27AVQ@186824|Thermoactinomycetaceae 91061|Bacilli J Putative GTP-binding controlling metal-binding ywlC GO:0000049,GO:0000166,GO:0002949,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006450,GO:0006725,GO:0006807,GO:0008033,GO:0008144,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034470,GO:0034641,GO:0034660,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0065007,GO:0065008,GO:0070525,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901363 2.7.7.87 ko:K07566 - - R10463 RC00745 ko00000,ko01000,ko03009,ko03016 - - - SUA5,Sua5_yciO_yrdC k59_225710_1 1408473.JHXO01000002_gene3836 4.33e-125 371.0 COG3664@1|root,COG3664@2|Bacteria,4NHQ0@976|Bacteroidetes,2FQ9R@200643|Bacteroidia 976|Bacteroidetes G Glycosyl hydrolases family 39 - - 3.2.1.37 ko:K01198 ko00520,ko01100,map00520,map01100 - R01433 RC00467 ko00000,ko00001,ko01000 - GH43 - Glyco_hydro_39 k59_1251724_1 702113.PP1Y_AT20428 9.36e-127 373.0 COG0760@1|root,COG0760@2|Bacteria,1MVB3@1224|Proteobacteria,2TSJ3@28211|Alphaproteobacteria,2K0UR@204457|Sphingomonadales 204457|Sphingomonadales O peptidylprolyl isomerase surA - 5.2.1.8 ko:K03771 - - - - ko00000,ko01000,ko03110 - - - Rotamase,SurA_N,SurA_N_3 k59_856593_1 1120983.KB894573_gene367 9.5e-60 212.0 COG4232@1|root,COG4233@1|root,COG4232@2|Bacteria,COG4233@2|Bacteria,1MU8W@1224|Proteobacteria,2VA2G@28211|Alphaproteobacteria,1JPF2@119043|Rhodobiaceae 28211|Alphaproteobacteria CO Disulphide bond corrector protein DsbC - - - - - - - - - - - - DsbC,DsbD,Thioredoxin_7 k59_1308230_1 1207063.P24_10720 9.03e-36 133.0 COG4663@1|root,COG4663@2|Bacteria,1MVMD@1224|Proteobacteria,2TS4J@28211|Alphaproteobacteria,2JPP5@204441|Rhodospirillales 204441|Rhodospirillales Q Part of the tripartite ATP-independent periplasmic (TRAP) transport system - - - - - - - - - - - - DctP k59_686473_1 713586.KB900536_gene612 9.72e-71 234.0 COG1674@1|root,COG1674@2|Bacteria,1MVPI@1224|Proteobacteria,1RM9A@1236|Gammaproteobacteria,1WWP6@135613|Chromatiales 135613|Chromatiales D DNA segregation ATPase FtsK SpoIIIE - - - ko:K03466 - - - - ko00000,ko03036 3.A.12 - - FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma k59_1759946_1 1226994.AMZB01000091_gene821 2.84e-63 204.0 COG0714@1|root,COG0714@2|Bacteria,1MUFN@1224|Proteobacteria,1RP45@1236|Gammaproteobacteria,1YDVU@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria S ATPase family associated with various cellular activities (AAA) moxR - - ko:K03924 - - - - ko00000,ko01000 - - - AAA_3 k59_1308238_2 1134413.ANNK01000135_gene3117 2.32e-06 50.1 COG2146@1|root,COG2146@2|Bacteria,1TU1F@1239|Firmicutes,4IM3H@91061|Bacilli,1ZJ0X@1386|Bacillus 91061|Bacilli P Rieske-like [2Fe-2S] domain - - - - - - - - - - - - Rieske k59_800297_1 1894.JOER01000052_gene6164 1.14e-05 54.3 COG0791@1|root,COG3409@1|root,COG0791@2|Bacteria,COG3409@2|Bacteria 2|Bacteria M Peptidoglycan-binding domain 1 protein - - 2.3.2.3 ko:K14205,ko:K21471 ko01503,ko02020,ko05150,map01503,map02020,map05150 M00726 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko01011,ko01504 2.A.1.3.37 - - CW_binding_1,NLPC_P60,PG_binding_1 k59_404105_1 1123270.ATUR01000005_gene614 1.07e-111 327.0 COG2801@1|root,COG2801@2|Bacteria,1MVN5@1224|Proteobacteria,2TQK0@28211|Alphaproteobacteria,2K2F6@204457|Sphingomonadales 204457|Sphingomonadales L COG2801 Transposase and inactivated derivatives - - - - - - - - - - - - HTH_21,rve_3 k59_1703345_1 316055.RPE_4895 1.65e-20 93.6 COG2885@1|root,COG2885@2|Bacteria,1MWHF@1224|Proteobacteria,2TUGX@28211|Alphaproteobacteria,3JTJQ@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria M Belongs to the ompA family MA20_22450 - - ko:K03286 - - - - ko00000,ko02000 1.B.6 - - BON,OmpA k59_1590207_1 189753.AXAS01000001_gene3671 1.49e-81 261.0 COG0145@1|root,COG0145@2|Bacteria,1MU2Y@1224|Proteobacteria,2TQZ6@28211|Alphaproteobacteria,3JSA9@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria EQ Hydantoinase/oxoprolinase - - 3.5.2.14 ko:K01473 ko00330,ko01100,map00330,map01100 - R03187 RC00632 ko00000,ko00001,ko01000 - - - Hydant_A_N,Hydantoinase_A,Hydantoinase_B k59_912793_1 1144305.PMI02_00188 3.41e-120 360.0 COG3206@1|root,COG3206@2|Bacteria,1MVBX@1224|Proteobacteria,2U1E2@28211|Alphaproteobacteria,2K08I@204457|Sphingomonadales 204457|Sphingomonadales M Chain-length determining protein - - - - - - - - - - - - GNVR,Wzz k59_348216_2 1121422.AUMW01000006_gene714 5.72e-18 87.4 COG0683@1|root,COG0683@2|Bacteria,1TPQ2@1239|Firmicutes,24CIR@186801|Clostridia,2606N@186807|Peptococcaceae 186801|Clostridia E PFAM Extracellular ligand-binding receptor - - - ko:K01999 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - Peripla_BP_6 k59_1138486_1 330214.NIDE3256 1.62e-125 366.0 COG1140@1|root,COG1140@2|Bacteria,3J1FU@40117|Nitrospirae 2|Bacteria C Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology ddhB GO:0005575,GO:0005623,GO:0042597,GO:0044464 1.7.5.1 ko:K00371,ko:K16965,ko:K17048,ko:K17051 ko00642,ko00910,ko00920,ko01100,ko01120,ko01220,ko02020,map00642,map00910,map00920,map01100,map01120,map01220,map02020 M00529,M00530,M00804 R00798,R01106,R05745,R09497,R09500 RC00275,RC02555,RC02812 ko00000,ko00001,ko00002,ko01000,ko02000 5.A.3.1,5.A.3.8,5.A.3.9 - - Fer4_11 k59_1703350_1 436308.Nmar_1105 1.99e-167 485.0 COG0556@1|root,arCOG04748@2157|Archaea,41T0H@651137|Thaumarchaeota 651137|Thaumarchaeota L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage uvrB - - ko:K03702 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - Helicase_C,ResIII,UVR,UvrB k59_234515_1 522306.CAP2UW1_4185 4.3e-115 355.0 COG4796@1|root,COG4796@2|Bacteria,1QTT6@1224|Proteobacteria,2VHY4@28216|Betaproteobacteria,1KQBW@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria U Bacterial type II and III secretion system protein pilQ - - ko:K02666 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - AMIN,STN,Secretin,Secretin_N k59_9220_1 1144305.PMI02_03525 4.6e-101 313.0 COG1298@1|root,COG1298@2|Bacteria,1MUF3@1224|Proteobacteria,2TQUR@28211|Alphaproteobacteria,2K2PH@204457|Sphingomonadales 204457|Sphingomonadales N Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin flhA - - ko:K02400 ko02040,map02040 - - - ko00000,ko00001,ko02035,ko02044 3.A.6.2,3.A.6.3 - - FHIPEP k59_65959_1 269799.Gmet_0526 2.71e-49 176.0 COG1368@1|root,COG1368@2|Bacteria,1MVCM@1224|Proteobacteria,42P62@68525|delta/epsilon subdivisions,2WKBP@28221|Deltaproteobacteria,43V54@69541|Desulfuromonadales 28221|Deltaproteobacteria M Sulfatase - - - - - - - - - - - - PAP2,Sulfatase k59_630076_1 471852.Tcur_2241 4.18e-71 234.0 COG1132@1|root,COG1132@2|Bacteria,2GITR@201174|Actinobacteria,4EFP3@85012|Streptosporangiales 201174|Actinobacteria V ABC transporter transmembrane region - - - ko:K06147 - - - - ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran k59_800322_1 864051.BurJ1DRAFT_2821 5.71e-142 412.0 COG0015@1|root,COG0015@2|Bacteria,1MXNN@1224|Proteobacteria,2VID3@28216|Betaproteobacteria,1KKNG@119065|unclassified Burkholderiales 28216|Betaproteobacteria F Adenylosuccinate lyase C-terminus - - 5.5.1.2 ko:K01857 ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220 - R03307 RC00902 ko00000,ko00001,ko01000 - - - ADSL_C,Lyase_1 k59_573498_2 1297865.APJD01000007_gene1978 1.66e-06 49.3 COG2303@1|root,COG2303@2|Bacteria,1MV19@1224|Proteobacteria,2TQKQ@28211|Alphaproteobacteria,3JUPN@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria E GMC oxidoreductase MA20_01285 - 1.1.99.1 ko:K00108 ko00260,ko01100,map00260,map01100 M00555 R01025 RC00087 ko00000,ko00001,ko00002,ko01000 - - - GMC_oxred_C,GMC_oxred_N k59_235780_2 396588.Tgr7_1224 1.37e-05 47.4 COG1706@1|root,COG1706@2|Bacteria,1MVKW@1224|Proteobacteria,1RMRB@1236|Gammaproteobacteria,1WVV3@135613|Chromatiales 135613|Chromatiales N Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation flgI - - ko:K02394 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - FlgI k59_67094_1 1229909.NSED_09300 4.87e-65 202.0 COG4063@1|root,arCOG03220@2157|Archaea,41T46@651137|Thaumarchaeota 651137|Thaumarchaeota H Tetrahydromethanopterin S-methyltransferase, subunit A - - 2.1.1.86 ko:K00577 ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200 M00357,M00567 R04347 RC00035,RC00113,RC02892 ko00000,ko00001,ko00002,ko01000 - - - MtrA k59_67094_2 1229909.NSED_09295 1.82e-66 203.0 arCOG08766@1|root,arCOG08766@2157|Archaea,41T41@651137|Thaumarchaeota 651137|Thaumarchaeota G dUTPase - - - - - - - - - - - - dUTPase_2 k59_518210_2 29581.BW37_01545 8.58e-07 50.8 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,472XU@75682|Oxalobacteraceae 28216|Betaproteobacteria T Putative diguanylate phosphodiesterase - - - - - - - - - - - - EAL,GGDEF,PAS_3,PAS_9 k59_1422175_1 1122137.AQXF01000001_gene3271 3.22e-128 371.0 COG0454@1|root,COG0454@2|Bacteria,1MVVG@1224|Proteobacteria,2TR1B@28211|Alphaproteobacteria 28211|Alphaproteobacteria K COG0454 Histone acetyltransferase HPA2 and related acetyltransferases - - - - - - - - - - - - Acetyltransf_1,Acetyltransf_10 k59_1422175_2 1122137.AQXF01000001_gene3270 2e-90 270.0 COG0708@1|root,COG0708@2|Bacteria,1MVMC@1224|Proteobacteria,2TRWQ@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Exodeoxyribonuclease III xthA2 - 3.1.11.2 ko:K01142 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - Exo_endo_phos k59_1309744_1 471855.Shel_16340 1.25e-53 190.0 COG0210@1|root,COG0210@2|Bacteria,2GISS@201174|Actinobacteria,4CUMT@84998|Coriobacteriia 84998|Coriobacteriia L DNA helicase - - 3.6.4.12 ko:K03657 ko03420,ko03430,map03420,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - UvrD-helicase,UvrD_C k59_858100_1 247634.GPB2148_712 3.14e-49 167.0 COG5008@1|root,COG5008@2|Bacteria,1QTTX@1224|Proteobacteria,1RN0B@1236|Gammaproteobacteria 1236|Gammaproteobacteria NU twitching motility protein pilU - - ko:K02670 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE k59_858100_2 1042377.AFPJ01000054_gene1713 1.06e-20 89.4 COG2805@1|root,COG2805@2|Bacteria,1MU3J@1224|Proteobacteria,1RN8G@1236|Gammaproteobacteria,464R4@72275|Alteromonadaceae 1236|Gammaproteobacteria NU COG2805 Tfp pilus assembly protein, pilus retraction ATPase PilT pilT GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - ko:K02669 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE k59_1535456_1 743299.Acife_0161 8.48e-171 507.0 COG0610@1|root,COG0610@2|Bacteria,1MU96@1224|Proteobacteria,1RP2Q@1236|Gammaproteobacteria,2NCAX@225057|Acidithiobacillales 225057|Acidithiobacillales V Subunit R is required for both nuclease and ATPase activities, but not for modification - - 3.1.21.3 ko:K01153 - - - - ko00000,ko01000,ko02048 - - - HSDR_N,ResIII k59_462093_1 349521.HCH_02819 3.63e-45 147.0 COG1343@1|root,COG1343@2|Bacteria,1MZ9Q@1224|Proteobacteria,1S93C@1236|Gammaproteobacteria,1XM4R@135619|Oceanospirillales 135619|Oceanospirillales L CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette cas2 - - ko:K09951 - - - - ko00000,ko02048 - - - CRISPR_Cas2 k59_462093_2 1283300.ATXB01000001_gene933 4.27e-18 81.6 COG1518@1|root,COG1518@2|Bacteria,1MUKK@1224|Proteobacteria,1RNYK@1236|Gammaproteobacteria,1XDTJ@135618|Methylococcales 135618|Methylococcales L CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette - - - ko:K15342 - - - - ko00000,ko02048,ko03400 - - - Cas_Cas1 k59_293002_1 1144307.PMI04_04564 6.73e-123 365.0 COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,2TRII@28211|Alphaproteobacteria,2K2B6@204457|Sphingomonadales 204457|Sphingomonadales I AMP-binding enzyme C-terminal domain - - 6.2.1.1,6.2.1.2 ko:K01895,ko:K01896 ko00010,ko00620,ko00640,ko00650,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00650,map00680,map00720,map01100,map01110,map01120,map01130,map01200 M00357 R00235,R00236,R00316,R00926,R01176,R01354 RC00004,RC00012,RC00014,RC00043,RC00070,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000,ko01004 - - - AMP-binding,AMP-binding_C k59_687984_1 1122137.AQXF01000002_gene326 1.75e-96 289.0 COG0331@1|root,COG0331@2|Bacteria,1MV6N@1224|Proteobacteria,2TRTT@28211|Alphaproteobacteria 28211|Alphaproteobacteria I malonyl CoA-acyl carrier protein transacylase fabD GO:0003674,GO:0003824,GO:0004312,GO:0004314,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016417,GO:0016419,GO:0016420,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0072330,GO:1901576 2.3.1.39 ko:K00645 ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212 M00082 R01626,R11671 RC00004,RC00039,RC02727 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Acyl_transf_1 k59_913965_1 351607.Acel_1789 1.87e-52 179.0 COG2201@1|root,COG2201@2|Bacteria,2GMBC@201174|Actinobacteria,4ES6U@85013|Frankiales 201174|Actinobacteria NT catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR cheB - 3.1.1.61,3.5.1.44 ko:K03412 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko02022,ko02035 - - - CheB_methylest,Response_reg k59_1704806_1 436308.Nmar_1367 7.5e-56 187.0 arCOG08650@1|root,arCOG08650@2157|Archaea,41SZ5@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1479597_1 644076.SCH4B_1852 1.63e-76 246.0 COG0471@1|root,COG0471@2|Bacteria,1MU0K@1224|Proteobacteria,2TSFS@28211|Alphaproteobacteria,4NAWE@97050|Ruegeria 28211|Alphaproteobacteria P TrkA-C domain protein - - - - - - - - - - - - CitMHS,Na_sulph_symp,TrkA_C k59_1535501_1 296591.Bpro_4706 3.53e-22 95.9 COG2801@1|root,COG2801@2|Bacteria,1MVXQ@1224|Proteobacteria,2VQF1@28216|Betaproteobacteria,4AEQ3@80864|Comamonadaceae 28216|Betaproteobacteria L PFAM Integrase catalytic insF - - ko:K07497 - - - - ko00000 - - - HTH_21,rve,rve_3 k59_462125_1 653733.Selin_1079 2.2e-10 68.2 COG5607@1|root,COG5607@2|Bacteria 2|Bacteria F PFAM CHAD domain containing protein sixA-2 - - ko:K08296 - - - - ko00000,ko01000 - - - CHAD,His_Phos_1 k59_10392_1 436308.Nmar_1578 3.08e-90 281.0 COG1001@1|root,arCOG00693@2157|Archaea,41SZH@651137|Thaumarchaeota 651137|Thaumarchaeota F Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family ade - 3.5.4.2 ko:K01486 ko00230,ko01100,map00230,map01100 - R01244 RC00477 ko00000,ko00001,ko01000 - - - Adenine_deam_C,Amidohydro_1 k59_801451_1 228410.NE0970 6.91e-47 164.0 COG0612@1|root,COG0612@2|Bacteria,1MU6R@1224|Proteobacteria,2VH8D@28216|Betaproteobacteria,3724I@32003|Nitrosomonadales 28216|Betaproteobacteria S PFAM Peptidase M16 - - - ko:K07263 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M16,Peptidase_M16_C k59_1704829_1 1123256.KB907925_gene1511 1.21e-10 61.6 COG3784@1|root,COG3784@2|Bacteria,1MYIH@1224|Proteobacteria,1S8D2@1236|Gammaproteobacteria,1X61X@135614|Xanthomonadales 135614|Xanthomonadales S Protein of unknown function (DUF1318) - - - - - - - - - - - - DUF1318 k59_1704829_2 395493.BegalDRAFT_3156 2.15e-17 82.0 COG2911@1|root,COG2911@2|Bacteria,1MW9V@1224|Proteobacteria,1S3FX@1236|Gammaproteobacteria,461VT@72273|Thiotrichales 72273|Thiotrichales S Protein conserved in bacteria - - - - - - - - - - - - - k59_462134_2 1122137.AQXF01000003_gene2361 3.04e-117 352.0 COG1115@1|root,COG1115@2|Bacteria,1MUI3@1224|Proteobacteria,2TQVA@28211|Alphaproteobacteria 28211|Alphaproteobacteria E alanine symporter - - - ko:K03310 - - - - ko00000 2.A.25 - - Na_Ala_symp k59_1761513_1 247634.GPB2148_1184 7.41e-91 279.0 28H52@1|root,2Z7HQ@2|Bacteria,1MXTF@1224|Proteobacteria,1RN8H@1236|Gammaproteobacteria,1J8US@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Protein of unknown function (DUF1329) - - - - - - - - - - - - DUF1329 k59_462143_1 228405.HNE_1958 3.23e-58 185.0 COG3837@1|root,COG3837@2|Bacteria,1R9WZ@1224|Proteobacteria,2U6K6@28211|Alphaproteobacteria,43Y7K@69657|Hyphomonadaceae 28211|Alphaproteobacteria S Cupin domain - - - - - - - - - - - - Cupin_2 k59_405659_1 471223.GWCH70_3186 3.82e-38 144.0 COG1943@1|root,COG3599@1|root,COG1943@2|Bacteria,COG3599@2|Bacteria,1TRNH@1239|Firmicutes,4HHNJ@91061|Bacilli,1WEPY@129337|Geobacillus 91061|Bacilli DL PFAM transposase IS66 - - - ko:K07484 - - - - ko00000 - - - DDE_Tnp_IS66,zf-IS66 k59_1591670_1 37919.EP51_21535 3.08e-45 155.0 COG0500@1|root,COG2226@2|Bacteria,2H9G5@201174|Actinobacteria,4FUPK@85025|Nocardiaceae 201174|Actinobacteria Q ubiE/COQ5 methyltransferase family - - - - - - - - - - - - Methyltransf_11,Methyltransf_23 k59_1591670_2 768671.ThimaDRAFT_3706 1.57e-97 308.0 COG0243@1|root,COG0243@2|Bacteria,1NS3T@1224|Proteobacteria,1RMWN@1236|Gammaproteobacteria,1WWTA@135613|Chromatiales 1236|Gammaproteobacteria C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family aoxB - - - - - - - - - - - Molybdopterin,Molydop_binding k59_1422273_1 870187.Thini_0877 1.78e-47 168.0 COG0843@1|root,COG0843@2|Bacteria,1QJ23@1224|Proteobacteria,1SKBI@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Cytochrome C and Quinol oxidase polypeptide I - - - - - - - - - - - - COX1 k59_1253277_1 1184607.AUCHE_08_04980 9.25e-47 160.0 COG2301@1|root,COG2301@2|Bacteria,2GK5J@201174|Actinobacteria,4F6NB@85018|Dermatophilaceae 201174|Actinobacteria G C-C_Bond_Lyase of the TIM-Barrel fold mcl2 - 4.1.3.34 ko:K01644 ko02020,map02020 - R00362 RC00067,RC01118 ko00000,ko00001,ko01000 - - - HpcH_HpaI,PEP-utilizers_C k59_349665_1 1502724.FF80_03732 2.14e-118 344.0 COG3293@1|root,COG3293@2|Bacteria,1PVIT@1224|Proteobacteria,2TURP@28211|Alphaproteobacteria,3N8G4@45401|Hyphomicrobiaceae 28211|Alphaproteobacteria L Transposase DDE domain - - - ko:K07492 - - - - ko00000 - - - DDE_Tnp_1,DDE_Tnp_1_2,DUF4096 k59_179597_1 1122137.AQXF01000006_gene817 7.85e-17 80.5 COG1629@1|root,COG4771@2|Bacteria,1MUWN@1224|Proteobacteria,2TUIR@28211|Alphaproteobacteria 28211|Alphaproteobacteria P COG1629 Outer membrane receptor proteins, mostly Fe transport - - - - - - - - - - - - CarbopepD_reg_2,CarboxypepD_reg,Plug,TonB_dep_Rec k59_179597_2 981384.AEYW01000016_gene45 1.22e-24 94.4 COG1278@1|root,COG1278@2|Bacteria,1N6Q5@1224|Proteobacteria,2UF6W@28211|Alphaproteobacteria,4NCNR@97050|Ruegeria 28211|Alphaproteobacteria K Cold shock protein domain - - - ko:K03704 - - - - ko00000,ko03000 - - - CSD k59_67190_1 1280950.HJO_08342 5.8e-24 106.0 COG1629@1|root,COG1629@2|Bacteria,1R479@1224|Proteobacteria,2TV3V@28211|Alphaproteobacteria,43Z4Z@69657|Hyphomonadaceae 28211|Alphaproteobacteria P COG1629 Outer membrane receptor proteins, mostly Fe transport - - - - - - - - - - - - Plug,STN,TonB_dep_Rec k59_349672_2 525245.HMPREF0044_0122 5.47e-09 59.3 COG4626@1|root,COG4626@2|Bacteria,2IH1M@201174|Actinobacteria,4D5X7@85005|Actinomycetales 201174|Actinobacteria S Phage Terminase - - - - - - - - - - - - Terminase_1 k59_1253297_1 1197477.IA57_01530 4.91e-98 317.0 COG0086@1|root,COG0086@2|Bacteria,4NEMW@976|Bacteroidetes,1HYVS@117743|Flavobacteriia 976|Bacteroidetes K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoC GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234 2.7.7.6 ko:K03046 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5 k59_405692_1 713586.KB900536_gene1568 6.79e-100 306.0 COG2170@1|root,COG2170@2|Bacteria,1MXET@1224|Proteobacteria,1RPKZ@1236|Gammaproteobacteria,1WWXK@135613|Chromatiales 135613|Chromatiales S glutamate--cysteine ligase - - - - - - - - - - - - GCS2 k59_349694_1 319225.Plut_0298 1.64e-24 107.0 COG1067@1|root,COG1067@2|Bacteria 2|Bacteria O ATP-dependent peptidase activity lonB - 3.4.21.53 ko:K01338,ko:K04076,ko:K04770 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - AAA_32,Lon_C k59_688050_1 436308.Nmar_0641 1.92e-88 268.0 arCOG08669@1|root,arCOG08669@2157|Archaea,41SEB@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1309834_2 314292.VAS14_02051 2.31e-195 547.0 COG1063@1|root,COG1063@2|Bacteria,1MV9A@1224|Proteobacteria,1RMNY@1236|Gammaproteobacteria,1XUZV@135623|Vibrionales 135623|Vibrionales C Catalyzes the NAD( )-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate tdh - 1.1.1.103 ko:K00060 ko00260,map00260 - R01465 RC00525 ko00000,ko00001,ko01000 - - - ADH_N,ADH_zinc_N k59_1309834_3 388739.RSK20926_09232 7.75e-09 55.8 COG0156@1|root,COG0156@2|Bacteria,1MVVH@1224|Proteobacteria,2TQYP@28211|Alphaproteobacteria,2P17B@2433|Roseobacter 28211|Alphaproteobacteria H Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA kbl - 2.3.1.29 ko:K00639 ko00260,map00260 - R00371 RC00004,RC00394 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_1_2 k59_518331_1 1122137.AQXF01000006_gene684 7.11e-168 475.0 COG1868@1|root,COG1868@2|Bacteria,1MX01@1224|Proteobacteria,2TR4F@28211|Alphaproteobacteria 28211|Alphaproteobacteria N FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation fliM - - ko:K02416 ko02030,ko02040,map02030,map02040 - - - ko00000,ko00001,ko02035 - - - FliM,FliMN_C k59_1704871_2 66897.DJ64_17135 3.22e-57 192.0 COG1073@1|root,COG1073@2|Bacteria,2GNB6@201174|Actinobacteria 201174|Actinobacteria L Alpha Beta - - - - - - - - - - - - Hydrolase_4,Peptidase_S15 k59_67212_2 589865.DaAHT2_1105 5.24e-64 209.0 COG0059@1|root,COG0059@2|Bacteria,1MV7M@1224|Proteobacteria,42MRS@68525|delta/epsilon subdivisions,2WJW8@28221|Deltaproteobacteria,2MIRN@213118|Desulfobacterales 28221|Deltaproteobacteria EH Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by ilvC - 1.1.1.86 ko:K00053 ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R03051,R04439,R04440,R05068,R05069,R05071 RC00726,RC00836,RC00837,RC01726 ko00000,ko00001,ko00002,ko01000 - - - IlvC,IlvN k59_123468_1 1246995.AFR_38655 8.89e-17 87.4 COG0438@1|root,COG0438@2|Bacteria 2|Bacteria M transferase activity, transferring glycosyl groups - - - - - - - - - - - - Glyco_transf_4,Glycos_transf_1 k59_123468_2 298654.FraEuI1c_0009 7.45e-19 85.1 COG0500@1|root,COG2226@2|Bacteria,2H38T@201174|Actinobacteria,4EU2T@85013|Frankiales 201174|Actinobacteria Q PFAM Methyltransferase type 11 - - - - - - - - - - - - Methyltransf_11 k59_1657517_2 351607.Acel_0703 4.29e-24 102.0 COG0493@1|root,COG1144@1|root,COG0493@2|Bacteria,COG1144@2|Bacteria,2GJ0A@201174|Actinobacteria,4ERK8@85013|Frankiales 201174|Actinobacteria C TIGRFAM glutamate synthase, NADH NADPH, small subunit preT - - - - - - - - - - - Fer4,Fer4_20,Pyr_redox_2,Pyr_redox_3 k59_131616_1 1123267.JONN01000001_gene1091 8.14e-09 58.5 COG0062@1|root,COG0063@1|root,COG0062@2|Bacteria,COG0063@2|Bacteria,1MU1Q@1224|Proteobacteria,2TT58@28211|Alphaproteobacteria,2K1P3@204457|Sphingomonadales 204457|Sphingomonadales G Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration nnrD - - - - - - - - - - - Carb_kinase,YjeF_N k59_131616_2 953739.SVEN_7032 1.62e-17 80.9 COG0736@1|root,COG0736@2|Bacteria,2IPP4@201174|Actinobacteria 201174|Actinobacteria I Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein - - 2.7.8.7 ko:K00997 ko00770,map00770 - R01625 RC00002 ko00000,ko00001,ko01000 - - - ACPS k59_131616_3 991.IW20_14435 5.46e-24 101.0 COG0449@1|root,COG0449@2|Bacteria,4NE8Q@976|Bacteroidetes,1HX0U@117743|Flavobacteriia,2NS9M@237|Flavobacterium 976|Bacteroidetes M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source glmS - 2.6.1.16 ko:K00820 ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931 - R00768 RC00010,RC00163,RC02752 ko00000,ko00001,ko01000,ko01002 - - - GATase_6,SIS k59_809884_1 100226.SCO4716 1.78e-30 111.0 COG0096@1|root,COG0096@2|Bacteria,2IHQZ@201174|Actinobacteria 201174|Actinobacteria J One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit rpsH GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0008150,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - ko:K02994 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S8 k59_809884_2 1287475.HMPREF1650_00355 6.99e-38 129.0 COG0199@1|root,COG0199@2|Bacteria,2IKN9@201174|Actinobacteria,22NID@1653|Corynebacteriaceae 201174|Actinobacteria J Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site rpsN GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02954 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S14 k59_131630_3 1452718.JBOY01000021_gene715 4.49e-36 135.0 COG0553@1|root,COG0553@2|Bacteria 2|Bacteria L helicase activity - - - - - - - - - - - - Helicase_C,SNF2_N k59_1091802_1 765913.ThidrDRAFT_3149 1.33e-32 127.0 COG2199@1|root,COG3706@2|Bacteria,1MZV7@1224|Proteobacteria,1RPR0@1236|Gammaproteobacteria,1X2B9@135613|Chromatiales 135613|Chromatiales T TIGRFAM Diguanylate cyclase - - - - - - - - - - - - GGDEF k59_640966_2 1444309.JAQG01000026_gene4099 3.03e-94 286.0 COG0012@1|root,COG0012@2|Bacteria,1TPRK@1239|Firmicutes,4H9SQ@91061|Bacilli,26RK6@186822|Paenibacillaceae 91061|Bacilli J ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner ychF GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0044424,GO:0044464 - ko:K06942 - - - - ko00000,ko03009 - - - MMR_HSR1,YchF-GTPase_C k59_1545276_1 1144305.PMI02_01203 8.22e-87 278.0 COG0542@1|root,COG0542@2|Bacteria,1MV8B@1224|Proteobacteria,2TQUZ@28211|Alphaproteobacteria,2K0MN@204457|Sphingomonadales 204457|Sphingomonadales O Belongs to the ClpA ClpB family clpA - - ko:K03694 - - - - ko00000,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N k59_867907_1 311424.DhcVS_89 2.2e-30 110.0 COG2963@1|root,COG2963@2|Bacteria,2GAW0@200795|Chloroflexi,34DGC@301297|Dehalococcoidia 301297|Dehalococcoidia L Transposase - - - - - - - - - - - - HTH_Tnp_1 k59_867907_2 1121028.ARQE01000016_gene2619 4.26e-44 152.0 COG2801@1|root,COG2801@2|Bacteria,1MVN5@1224|Proteobacteria,2TQK0@28211|Alphaproteobacteria,2PK0U@255475|Aurantimonadaceae 28211|Alphaproteobacteria L Integrase core domain - - - - - - - - - - - - HTH_21,rve,rve_3 k59_471353_1 94624.Bpet0693 9.2e-54 191.0 COG0769@1|root,COG0770@1|root,COG0769@2|Bacteria,COG0770@2|Bacteria,1QTSF@1224|Proteobacteria,2VH2H@28216|Betaproteobacteria,3T2I5@506|Alcaligenaceae 28216|Betaproteobacteria M Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan murF - 6.3.2.10,6.3.2.13 ko:K01929,ko:K15792 ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502 - R02788,R04573,R04617 RC00064,RC00090,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_414774_1 702113.PP1Y_AT314 1.64e-224 638.0 COG0542@1|root,COG0542@2|Bacteria,1MV8B@1224|Proteobacteria,2TQUZ@28211|Alphaproteobacteria,2K0MN@204457|Sphingomonadales 204457|Sphingomonadales O Belongs to the ClpA ClpB family clpA - - ko:K03694 - - - - ko00000,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N k59_1658575_1 1122137.AQXF01000004_gene1843 6.87e-87 266.0 COG1266@1|root,COG1266@2|Bacteria,1MY1N@1224|Proteobacteria,2U3EH@28211|Alphaproteobacteria 28211|Alphaproteobacteria S infection protein - - - ko:K07052 - - - - ko00000 - - - Abi k59_697492_1 1249627.D779_3352 5.01e-120 378.0 COG0085@1|root,COG0085@2|Bacteria,1MUC4@1224|Proteobacteria,1RMK0@1236|Gammaproteobacteria,1WX4P@135613|Chromatiales 135613|Chromatiales K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoB - 2.7.7.6 ko:K03043 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7 k59_1714273_1 1122137.AQXF01000003_gene2437 1.07e-33 117.0 COG4321@1|root,COG4321@2|Bacteria 2|Bacteria O Ribbon-helix-helix domain - - - - - - - - - - - - RHH_4 k59_1714273_2 1122137.AQXF01000003_gene2436 2.35e-71 246.0 COG2982@1|root,COG2982@2|Bacteria,1MUNH@1224|Proteobacteria,2TT0W@28211|Alphaproteobacteria 28211|Alphaproteobacteria M protein involved in outer membrane biogenesis asmA - - ko:K07289 - - - - ko00000 - - - AsmA,AsmA_2 k59_867940_1 1207055.C100_23705 3.53e-27 103.0 COG0723@1|root,COG0723@2|Bacteria,1RAA2@1224|Proteobacteria,2TTT2@28211|Alphaproteobacteria,2K1YX@204457|Sphingomonadales 204457|Sphingomonadales C Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis petA - 1.10.2.2 ko:K00411 ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016 M00151,M00152 - - ko00000,ko00001,ko00002,ko01000 - - - Rieske,UCR_Fe-S_N k59_867940_2 1088721.NSU_1833 2.04e-158 452.0 COG1290@1|root,COG1290@2|Bacteria,1MV97@1224|Proteobacteria,2TSZ3@28211|Alphaproteobacteria,2K0CE@204457|Sphingomonadales 204457|Sphingomonadales C Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis petB - - ko:K00412 ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016 M00151,M00152 - - ko00000,ko00001,ko00002,ko03029 - - - Cytochrom_B_C,Cytochrome_B k59_584377_1 78245.Xaut_3805 2.56e-15 84.0 COG0604@1|root,COG1028@1|root,COG3321@1|root,COG0604@2|Bacteria,COG1028@2|Bacteria,COG3321@2|Bacteria,1R89Z@1224|Proteobacteria,2UR2U@28211|Alphaproteobacteria,3EYIN@335928|Xanthobacteraceae 28211|Alphaproteobacteria CIQ KR domain protein rkpA - - - - - - - - - - - ADH_N,ADH_zinc_N,ADH_zinc_N_2,Acyl_transf_1,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,PS-DH,ketoacyl-synt k59_1092769_1 1229909.NSED_09385 3.26e-15 68.2 arCOG08748@1|root,arCOG08748@2157|Archaea,41SV7@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_302768_1 439235.Dalk_0753 9.25e-44 161.0 COG1033@1|root,COG1033@2|Bacteria,1MUE1@1224|Proteobacteria,42ME2@68525|delta/epsilon subdivisions,2WJRI@28221|Deltaproteobacteria,2MHZ1@213118|Desulfobacterales 28221|Deltaproteobacteria S Sterol-sensing domain of SREBP cleavage-activation - - - ko:K07003 - - - - ko00000 - - - MMPL k59_1431619_1 1122194.AUHU01000010_gene3108 1.04e-53 181.0 COG2211@1|root,COG2211@2|Bacteria,1MVUM@1224|Proteobacteria,1RP5J@1236|Gammaproteobacteria,464K4@72275|Alteromonadaceae 1236|Gammaproteobacteria G COG2211 Na melibiose symporter and related transporters - - - ko:K03292 - - - - ko00000 2.A.2 - - MFS_2 k59_1431619_2 1216007.AOPM01000064_gene1620 1.27e-25 102.0 COG3940@1|root,COG3940@2|Bacteria,1NKF0@1224|Proteobacteria,1RNIH@1236|Gammaproteobacteria 1236|Gammaproteobacteria G Belongs to the glycosyl hydrolase 43 family abf2 - - - - - - - - - - - Glyco_hydro_43 k59_77200_1 1122137.AQXF01000007_gene3625 2.63e-17 80.9 COG2224@1|root,COG2224@2|Bacteria,1MWIF@1224|Proteobacteria,2TU0Q@28211|Alphaproteobacteria 28211|Alphaproteobacteria C Isocitrate lyase aceA - 4.1.3.1 ko:K01637 ko00630,ko01100,ko01110,ko01120,ko01200,map00630,map01100,map01110,map01120,map01200 M00012 R00479 RC00311,RC00313 ko00000,ko00001,ko00002,ko01000 - - - ICL k59_77200_2 1122137.AQXF01000007_gene3626 8.41e-49 167.0 COG3800@1|root,COG3800@2|Bacteria,1MU50@1224|Proteobacteria,2TRKE@28211|Alphaproteobacteria 28211|Alphaproteobacteria K transcriptional regulator - - - ko:K07110 - - - - ko00000,ko03000 - - - DUF2083,HTH_19,HTH_3,HTH_31,Peptidase_M78 k59_979051_1 251221.35211042 2.06e-05 48.5 COG1309@1|root,COG1309@2|Bacteria,1GDB4@1117|Cyanobacteria 1117|Cyanobacteria K BetI-type transcriptional repressor, C-terminal - - - - - - - - - - - - TetR_C_6,TetR_N k59_1431620_1 292.DM42_7161 4.54e-68 218.0 COG1659@1|root,COG1659@2|Bacteria,1QKHQ@1224|Proteobacteria,2VZYS@28216|Betaproteobacteria,1K1YZ@119060|Burkholderiaceae 28216|Betaproteobacteria S PFAM Linocin_M18 bacteriocin protein - - - - - - - - - - - - Linocin_M18 k59_471386_1 243365.CV_1033 2.25e-29 122.0 COG2202@1|root,COG4192@1|root,COG5001@1|root,COG2202@2|Bacteria,COG4192@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,2KQT8@206351|Neisseriales 206351|Neisseriales T signal transduction protein containing a membrane domain, an EAL and a GGDEF domain - - - - - - - - - - - - EAL,GGDEF,HAMP,PAS_9 k59_1262092_1 391625.PPSIR1_27198 2.43e-34 138.0 COG2203@1|root,COG3899@1|root,COG4191@1|root,COG2203@2|Bacteria,COG3899@2|Bacteria,COG4191@2|Bacteria,1R609@1224|Proteobacteria,42MTJ@68525|delta/epsilon subdivisions,2WJYM@28221|Deltaproteobacteria,2Z38S@29|Myxococcales 28221|Deltaproteobacteria T COG0515 Serine threonine protein kinase - - - - - - - - - - - - AAA_16,GAF,GAF_2,HATPase_c,HisKA,PAS_3,PAS_4,PAS_9,Pkinase k59_979056_1 869209.Tresu_0038 2.8e-06 55.8 COG1502@1|root,COG1502@2|Bacteria,2J62N@203691|Spirochaetes 203691|Spirochaetes I Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol - - - ko:K06131 ko00564,ko01100,map00564,map01100 - R07390 RC00017 ko00000,ko00001,ko01000 - - - PLDc_2,PLDc_N k59_1489112_1 745718.JADT01000004_gene1255 4e-85 259.0 COG4974@1|root,COG4974@2|Bacteria,4NGQW@976|Bacteroidetes,1HWMN@117743|Flavobacteriia 976|Bacteroidetes L Belongs to the 'phage' integrase family xerC - - ko:K03733 - - - - ko00000,ko03036 - - - Phage_int_SAM_1,Phage_integrase k59_19841_1 113395.AXAI01000003_gene6016 2.81e-31 127.0 COG4191@1|root,COG5000@1|root,COG4191@2|Bacteria,COG5000@2|Bacteria,1RCM9@1224|Proteobacteria,2TQQ9@28211|Alphaproteobacteria,3JTQS@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HAMP,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg,dCache_1 k59_1545348_1 494416.AYXN01000012_gene1243 3.64e-38 153.0 COG2902@1|root,COG2902@2|Bacteria,1MXNV@1224|Proteobacteria,1RQVZ@1236|Gammaproteobacteria,3NR8V@468|Moraxellaceae 1236|Gammaproteobacteria E Bacterial NAD-glutamate dehydrogenase gdhB - 1.4.1.2 ko:K15371 ko00220,ko00250,ko00430,ko00910,ko01100,map00220,map00250,map00430,map00910,map01100 - R00243 RC00006,RC02799 ko00000,ko00001,ko01000 - - - Bac_GDH,GDH_N k59_189551_1 861299.J421_3813 4.03e-259 736.0 COG1523@1|root,COG1523@2|Bacteria,1ZV42@142182|Gemmatimonadetes 142182|Gemmatimonadetes G Carbohydrate-binding module 48 (Isoamylase N-terminal domain) - - 3.2.1.68 ko:K01214 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R09995,R11261 - ko00000,ko00001,ko00002,ko01000 - CBM48,GH13 - CBM_48 k59_414814_1 555779.Dthio_PD2502 1.5e-29 115.0 COG2201@1|root,COG2201@2|Bacteria,1MWCN@1224|Proteobacteria,42M27@68525|delta/epsilon subdivisions,2WJ2S@28221|Deltaproteobacteria,2M8K6@213115|Desulfovibrionales 28221|Deltaproteobacteria NT catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR cheB - 3.1.1.61,3.5.1.44 ko:K03412 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko02022,ko02035 - - - CheB_methylest,Response_reg k59_414814_2 456320.Mvol_0949 1.09e-09 60.8 COG0643@1|root,arCOG04403@2157|Archaea,2XSUS@28890|Euryarchaeota,23QQT@183939|Methanococci 183939|Methanococci T P2 response regulator binding domain protein - - 2.7.13.3 ko:K03407 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 - - - CheW,H-kinase_dim,HATPase_c,Hpt,P2 k59_77231_1 1234364.AMSF01000015_gene3100 1.86e-59 206.0 COG4993@1|root,COG4993@2|Bacteria,1MUQX@1224|Proteobacteria,1RN5D@1236|Gammaproteobacteria,1X4FN@135614|Xanthomonadales 135614|Xanthomonadales G Glucose dehydrogenase - - - - - - - - - - - - PQQ,PQQ_2 k59_1037678_2 1120792.JAFV01000001_gene84 5.22e-28 113.0 COG0483@1|root,COG0483@2|Bacteria,1MV4W@1224|Proteobacteria,2TV4R@28211|Alphaproteobacteria,36YDW@31993|Methylocystaceae 28211|Alphaproteobacteria G Inositol monophosphatase family suhB2 - 3.1.3.25 ko:K01092 ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070 M00131 R01185,R01186,R01187 RC00078 ko00000,ko00001,ko00002,ko01000 - - - Inositol_P k59_1545367_1 702113.PP1Y_AT6202 2.94e-88 276.0 COG1217@1|root,COG1217@2|Bacteria,1MV5Q@1224|Proteobacteria,2TR63@28211|Alphaproteobacteria,2K169@204457|Sphingomonadales 204457|Sphingomonadales T GTP-binding protein TypA typA - - ko:K06207 - - - - ko00000 - - - EFG_C,GTP_EFTU,GTP_EFTU_D2 k59_1262110_1 1411685.U062_01340 1.26e-62 202.0 COG3137@1|root,COG3137@2|Bacteria,1RHDT@1224|Proteobacteria,1S1K4@1236|Gammaproteobacteria,1J6JF@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Protein of unknown function, DUF481 - - - - - - - - - - - - DUF481 k59_245372_1 215803.DB30_8735 9.06e-56 192.0 COG1641@1|root,COG1641@2|Bacteria,1MUKU@1224|Proteobacteria,42MHQ@68525|delta/epsilon subdivisions,2WJAC@28221|Deltaproteobacteria,2YUS7@29|Myxococcales 28221|Deltaproteobacteria S Belongs to the LarC family - - 4.99.1.12 ko:K09121 - - - - ko00000,ko01000 - - - DUF111 k59_1658630_1 1266909.AUAG01000008_gene2004 6.24e-64 203.0 COG0500@1|root,COG2226@2|Bacteria,1RDD9@1224|Proteobacteria,1S71N@1236|Gammaproteobacteria 1236|Gammaproteobacteria Q Methyltransferase type 11 - - - - - - - - - - - - Methyltransf_11 k59_584431_1 1122137.AQXF01000002_gene594 1.74e-84 265.0 COG4664@1|root,COG4664@2|Bacteria,1R4MZ@1224|Proteobacteria,2TQNR@28211|Alphaproteobacteria 28211|Alphaproteobacteria Q TRAP-type mannitol chloroaromatic compound transport system large permease component - - - - - - - - - - - - DctM k59_19878_1 1122137.AQXF01000004_gene1436 7.18e-76 240.0 COG0719@1|root,COG0719@2|Bacteria,1MVK0@1224|Proteobacteria,2TTK9@28211|Alphaproteobacteria 28211|Alphaproteobacteria O ABC-type transport system involved in Fe-S cluster assembly, permease component sufD - - ko:K09015 - - - - ko00000 - - - UPF0051 k59_1149282_1 1396858.Q666_07940 3e-38 141.0 COG2603@1|root,COG2603@2|Bacteria,1N4T5@1224|Proteobacteria,1RPFP@1236|Gammaproteobacteria,46469@72275|Alteromonadaceae 1236|Gammaproteobacteria H Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA selU GO:0001887,GO:0002097,GO:0002098,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016785,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043828,GO:0044237,GO:0044238,GO:0046483,GO:0070329,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 - ko:K06917 - - - - ko00000,ko01000,ko03016 - - - Rhodanese k59_1376140_1 945713.IALB_0893 7.46e-105 325.0 COG1034@1|root,COG3383@1|root,COG1034@2|Bacteria,COG3383@2|Bacteria 2|Bacteria C formate dehydrogenase (NAD+) activity nuoG - 1.6.5.3 ko:K00336 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Fer2_4,Fer4,Fer4_7,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3 k59_1770903_1 690850.Desaf_2584 8.55e-72 229.0 COG0385@1|root,COG0385@2|Bacteria,1Q36S@1224|Proteobacteria,42WV7@68525|delta/epsilon subdivisions,2WSXX@28221|Deltaproteobacteria 28221|Deltaproteobacteria S PFAM Bile acid sodium symporter - - - ko:K03453 - - - - ko00000 2.A.28 - - SBF k59_1770903_2 1177928.TH2_10059 2.37e-06 48.5 COG3637@1|root,COG3637@2|Bacteria,1R3Z1@1224|Proteobacteria,2U1SQ@28211|Alphaproteobacteria 28211|Alphaproteobacteria M Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety - - - - - - - - - - - - OMP_b-brl k59_1489152_1 1121875.KB907550_gene788 3.17e-105 336.0 COG1413@1|root,COG2133@1|root,COG3474@1|root,COG1413@2|Bacteria,COG2133@2|Bacteria,COG3474@2|Bacteria 2|Bacteria C electron transfer activity - - - ko:K02305,ko:K08738 ko00910,ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00910,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416 M00529,M00595 R00294,R10151 RC02794,RC03151,RC03152 ko00000,ko00001,ko00002 3.D.4.10,3.D.4.6 - - Cytochrom_C,HEAT_2 k59_753887_1 1121374.KB891576_gene248 4.8e-93 300.0 COG2304@1|root,COG2304@2|Bacteria,1MW8K@1224|Proteobacteria,1RNU3@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Von willebrand factor, type a - - - ko:K07114 - - - - ko00000,ko02000 1.A.13.2.2,1.A.13.2.3 - - VIT,VWA_3 k59_132806_2 926556.Echvi_1469 2.22e-37 138.0 COG0138@1|root,COG0138@2|Bacteria,4NEZD@976|Bacteroidetes,47JQT@768503|Cytophagia 976|Bacteroidetes F Bifunctional purine biosynthesis protein PurH purH - 2.1.2.3,3.5.4.10 ko:K00602 ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523 M00048 R01127,R04560 RC00026,RC00263,RC00456 ko00000,ko00001,ko00002,ko01000,ko04147 - - - AICARFT_IMPCHas,MGS k59_19903_2 1122137.AQXF01000002_gene97 2.18e-12 65.9 COG0187@1|root,COG0187@2|Bacteria,1MVH1@1224|Proteobacteria,2TQZV@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule parE - - ko:K02622 - - - - ko00000,ko01000,ko02048,ko03032,ko03036 - - - DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim k59_1376159_1 1117647.M5M_00030 1.84e-97 310.0 COG0013@1|root,COG0013@2|Bacteria,1MU9A@1224|Proteobacteria,1RMWZ@1236|Gammaproteobacteria,1J58G@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain alaS GO:0001130,GO:0001131,GO:0001141,GO:0001217,GO:0002161,GO:0002196,GO:0003674,GO:0003700,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006355,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006450,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009451,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016070,GO:0016597,GO:0016787,GO:0016788,GO:0016874,GO:0016875,GO:0019219,GO:0019222,GO:0019538,GO:0019752,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0042802,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045934,GO:0046483,GO:0046872,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0052689,GO:0060255,GO:0065007,GO:0065008,GO:0071704,GO:0080090,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:0140110,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 6.1.1.7 ko:K01872 ko00970,map00970 M00359,M00360 R03038 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iECABU_c1320.ECABU_c29670,iECED1_1282.ECED1_3146,iEcHS_1320.EcHS_A2833,iJN746.PP_4474 DHHA1,tRNA-synt_2c,tRNA_SAD k59_923613_1 1173023.KE650771_gene1413 5.11e-50 185.0 COG0515@1|root,COG3899@1|root,COG4191@1|root,COG0515@2|Bacteria,COG3899@2|Bacteria,COG4191@2|Bacteria,1GBKM@1117|Cyanobacteria,1JI2C@1189|Stigonemataceae 1117|Cyanobacteria T AAA ATPase domain - - - - - - - - - - - - AAA_16,GAF,HATPase_c,HisKA,PAS_3,PAS_9,Pkinase k59_1037741_1 1232410.KI421421_gene3823 1.05e-51 177.0 COG3016@1|root,COG3016@2|Bacteria,1MX1I@1224|Proteobacteria,42U2R@68525|delta/epsilon subdivisions,2WQAR@28221|Deltaproteobacteria,43SXZ@69541|Desulfuromonadales 28221|Deltaproteobacteria O Haem-binding uptake, Tiki superfamily, ChaN - - - - - - - - - - - - Cofac_haem_bdg,PDZ_2,Peptidase_M1 k59_1489187_1 1121877.JQKF01000002_gene1618 1.26e-10 66.6 COG1222@1|root,COG1222@2|Bacteria,2GMR1@201174|Actinobacteria,4CMRU@84992|Acidimicrobiia 84992|Acidimicrobiia O Proteasomal ATPase OB/ID domain arc - - ko:K13527 ko03050,map03050 M00342 - - ko00000,ko00001,ko00002,ko03051 - - - AAA,Prot_ATP_ID_OB k59_19920_1 158500.BV97_03786 1.05e-112 332.0 COG0179@1|root,COG0179@2|Bacteria,1MUPF@1224|Proteobacteria,2TQQG@28211|Alphaproteobacteria,2K0DM@204457|Sphingomonadales 28211|Alphaproteobacteria Q 2-keto-4-pentenoate hydratase 2-oxohepta-3-ene-1,7-dioic acid hydratase - - - - - - - - - - - - DUF2437,FAA_hydrolase k59_527366_2 1144275.COCOR_06286 8.16e-111 333.0 COG1459@1|root,COG1459@2|Bacteria,1MV4U@1224|Proteobacteria,42NES@68525|delta/epsilon subdivisions,2WJ0V@28221|Deltaproteobacteria,2YU38@29|Myxococcales 28221|Deltaproteobacteria NU Type II secretion system (T2SS), protein F pilC - - ko:K02653 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSF k59_1149333_1 1380600.AUYN01000001_gene2546 8.57e-77 244.0 COG1866@1|root,COG1866@2|Bacteria,4NEGI@976|Bacteroidetes,1HX6C@117743|Flavobacteriia 976|Bacteroidetes H Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA pckA - 4.1.1.49 ko:K01610 ko00010,ko00020,ko00620,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00710,map01100,map01110,map01120,map01130,map01200 M00003,M00170 R00341 RC00002,RC02741 ko00000,ko00001,ko00002,ko01000 - - - PEPCK_ATP k59_527367_1 402881.Plav_1394 1.48e-57 201.0 COG3127@1|root,COG3127@2|Bacteria,1MU9R@1224|Proteobacteria,2TS8V@28211|Alphaproteobacteria,1JN72@119043|Rhodobiaceae 28211|Alphaproteobacteria Q FtsX-like permease family MA20_43810 - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_359391_1 1236494.BAJN01000010_gene1480 6.92e-43 159.0 COG3250@1|root,COG3250@2|Bacteria,4NEDF@976|Bacteroidetes,2FMTQ@200643|Bacteroidia 976|Bacteroidetes G Belongs to the glycosyl hydrolase 2 family - - 3.2.1.23 ko:K01190 ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100 - R01105,R01678,R03355,R04783,R06114 RC00049,RC00452 ko00000,ko00001,ko01000 - - - DUF4982,Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N k59_1714409_1 941824.TCEL_02004 8.74e-83 272.0 COG0474@1|root,COG0474@2|Bacteria,1TPF5@1239|Firmicutes,247JN@186801|Clostridia,36DDM@31979|Clostridiaceae 186801|Clostridia P ATPase, P-type (transporting), HAD superfamily, subfamily IC - - 3.6.3.8 ko:K01537 - - - - ko00000,ko01000 3.A.3.2 - - Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase k59_1658685_1 1459636.NTE_02477 7.71e-70 219.0 COG0317@1|root,arCOG06870@2157|Archaea 2157|Archaea KT HD domain - - 2.7.6.5,3.1.7.2 ko:K00951,ko:K01139 ko00230,map00230 - R00336,R00429 RC00002,RC00078 ko00000,ko00001,ko01000,ko03009 - - - HD_4 k59_19936_1 1096930.L284_10780 5.55e-147 423.0 COG0677@1|root,COG0677@2|Bacteria,1MUC6@1224|Proteobacteria,2TR5F@28211|Alphaproteobacteria,2K04J@204457|Sphingomonadales 204457|Sphingomonadales M Belongs to the UDP-glucose GDP-mannose dehydrogenase family wecC - 1.1.1.336 ko:K02472 ko00520,ko05111,map00520,map05111 - R03317 RC00291 ko00000,ko00001,ko01000 - - - UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N k59_1714417_1 243230.DR_1720 3.95e-91 293.0 COG1048@1|root,COG1048@2|Bacteria,1WIMG@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus C Catalyzes the isomerization of citrate to isocitrate via cis-aconitate acn GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003730,GO:0003824,GO:0003994,GO:0005488,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017144,GO:0019541,GO:0019679,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0045333,GO:0046459,GO:0047456,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0071704,GO:0072350,GO:0097159,GO:1901363 4.2.1.3 ko:K01681 ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00173,M00740 R01324,R01325,R01900 RC00497,RC00498,RC00618 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase,Aconitase_C k59_1489207_1 377629.TERTU_3213 2.01e-69 229.0 COG1185@1|root,COG1185@2|Bacteria,1MVB9@1224|Proteobacteria,1RNBF@1236|Gammaproteobacteria,2PN46@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria J KH domain pnp GO:0000166,GO:0000175,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004518,GO:0004527,GO:0004532,GO:0004540,GO:0004654,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0008408,GO:0009056,GO:0009057,GO:0009266,GO:0009408,GO:0009628,GO:0009892,GO:0009987,GO:0010468,GO:0010605,GO:0010629,GO:0016070,GO:0016071,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016796,GO:0016896,GO:0017076,GO:0019001,GO:0019222,GO:0019439,GO:0030551,GO:0032553,GO:0032555,GO:0032561,GO:0034641,GO:0034655,GO:0035438,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0050896,GO:0060255,GO:0065007,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0097159,GO:0097367,GO:0140098,GO:1901265,GO:1901360,GO:1901361,GO:1901363,GO:1901575 2.7.7.8 ko:K00962 ko00230,ko00240,ko03018,map00230,map00240,map03018 M00394 R00437,R00438,R00439,R00440 RC02795 ko00000,ko00001,ko00002,ko01000,ko03016,ko03019 - - - KH_1,PNPase,RNase_PH,RNase_PH_C,S1 k59_189644_1 388051.AUFE01000001_gene2188 3.01e-102 318.0 COG1034@1|root,COG1034@2|Bacteria,1P8MN@1224|Proteobacteria,2VJYV@28216|Betaproteobacteria,1JZXQ@119060|Burkholderiaceae 28216|Betaproteobacteria C NADH-quinone oxidoreductase nuoG - 1.6.5.3 ko:K00336 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Fer2_4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3 k59_753926_1 399795.CtesDRAFT_PD4914 1.75e-53 181.0 COG4992@1|root,COG4992@2|Bacteria,1MV3C@1224|Proteobacteria,2VHEB@28216|Betaproteobacteria,4AD0Q@80864|Comamonadaceae 28216|Betaproteobacteria E acetylornithine - - 2.6.1.11,2.6.1.17 ko:K00821 ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00028,M00845 R02283,R04475 RC00006,RC00062 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 k59_697640_1 1229909.NSED_08170 5.45e-119 342.0 arCOG08638@1|root,arCOG08638@2157|Archaea,41T08@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_697644_1 1134474.O59_002438 3.75e-41 150.0 COG1028@1|root,COG3347@1|root,COG1028@2|Bacteria,COG3347@2|Bacteria,1MWSB@1224|Proteobacteria,1RNTD@1236|Gammaproteobacteria 1236|Gammaproteobacteria IQ Class II Aldolase and Adducin N-terminal domain - - - - - - - - - - - - Aldolase_II,adh_short_C2 k59_1101751_1 1121373.KB903630_gene282 7.51e-20 92.0 COG2267@1|root,COG2267@2|Bacteria,4NK38@976|Bacteroidetes,47N7P@768503|Cytophagia 976|Bacteroidetes I Protein of unknown function (DUF3089) - - - - - - - - - - - - DUF3089 k59_1327473_1 1122137.AQXF01000001_gene3010 1.59e-188 538.0 COG0481@1|root,COG0481@2|Bacteria,1MVZA@1224|Proteobacteria,2TR3H@28211|Alphaproteobacteria 28211|Alphaproteobacteria M Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner lepA - - ko:K03596 ko05134,map05134 - - - ko00000,ko00001 - - - EFG_C,EFG_II,GTP_EFTU,GTP_EFTU_D2,LepA_C k59_1101754_1 314345.SPV1_11186 1.93e-33 124.0 COG3440@1|root,COG3440@2|Bacteria,1N4JP@1224|Proteobacteria 1224|Proteobacteria L restriction endonuclease - - - ko:K07454 - - - - ko00000 - - - HNH_2 k59_1270739_1 118173.KB235914_gene2427 9.09e-49 171.0 COG1175@1|root,COG1175@2|Bacteria,1G0YN@1117|Cyanobacteria,1H7ZN@1150|Oscillatoriales 1117|Cyanobacteria P PFAM Binding-protein-dependent transport system inner membrane component ugpA - - ko:K02025 - M00207 - - ko00000,ko00002,ko02000 3.A.1.1 - - BPD_transp_1 k59_424128_1 1122137.AQXF01000001_gene3126 2.26e-67 212.0 COG1024@1|root,COG1024@2|Bacteria,1MVPQ@1224|Proteobacteria,2TTJ4@28211|Alphaproteobacteria 28211|Alphaproteobacteria I Enoyl-CoA hydratase MA20_32365 - - - - - - - - - - - ECH_1 k59_424128_2 1122137.AQXF01000001_gene3125 3.32e-17 76.6 COG4539@1|root,COG4539@2|Bacteria,1RHUB@1224|Proteobacteria 1224|Proteobacteria S membrane - - - - - - - - - - - - DUF962 k59_371303_1 1415754.JQMK01000012_gene834 2.36e-29 118.0 COG5281@1|root,COG5281@2|Bacteria,1NZ1M@1224|Proteobacteria,1S7A2@1236|Gammaproteobacteria,46DM9@72275|Alteromonadaceae 1236|Gammaproteobacteria D sister chromatid segregation - - - - - - - - - - - - - k59_1612767_1 1088721.NSU_0971 1.92e-54 172.0 COG3785@1|root,COG3785@2|Bacteria,1RHM7@1224|Proteobacteria,2U9MS@28211|Alphaproteobacteria,2K54K@204457|Sphingomonadales 204457|Sphingomonadales S DNA-binding protein - - - ko:K11940 - - - - ko00000,ko03036 - - - YccV-like k59_256601_1 338966.Ppro_3621 1.27e-56 192.0 COG0445@1|root,COG0445@2|Bacteria,1MU6F@1224|Proteobacteria,42KZC@68525|delta/epsilon subdivisions,2WJ31@28221|Deltaproteobacteria,43TF6@69541|Desulfuromonadales 28221|Deltaproteobacteria D NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 gidA GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901363 - ko:K03495 - - R08701 RC00053,RC00209,RC00870 ko00000,ko03016,ko03036 - - - GIDA,GIDA_assoc k59_256601_2 1232410.KI421422_gene2038 5.75e-15 74.7 COG0486@1|root,COG0486@2|Bacteria,1MUCQ@1224|Proteobacteria,42M6T@68525|delta/epsilon subdivisions,2WIWY@28221|Deltaproteobacteria,43TPQ@69541|Desulfuromonadales 28221|Deltaproteobacteria J Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 mnmE - - ko:K03650 - - R08701 RC00053,RC00209,RC00870 ko00000,ko01000,ko03016 - - - MMR_HSR1,MnmE_helical,TrmE_N k59_371321_1 566466.NOR53_1183 1.64e-83 255.0 COG0179@1|root,COG0179@2|Bacteria,1NN9V@1224|Proteobacteria,1RYW8@1236|Gammaproteobacteria 1236|Gammaproteobacteria Q Fumarylacetoacetate (FAA) hydrolase family - - - - - - - - - - - - DUF2437,FAA_hydrolase k59_1387849_1 247633.GP2143_16501 1.54e-105 320.0 COG1171@1|root,COG1171@2|Bacteria,1MVWJ@1224|Proteobacteria,1RMY6@1236|Gammaproteobacteria,1J4D3@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA ilvA GO:0003674,GO:0003824,GO:0004794,GO:0005488,GO:0006082,GO:0006520,GO:0006549,GO:0006566,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009081,GO:0009082,GO:0009097,GO:0009987,GO:0016053,GO:0016597,GO:0016829,GO:0016840,GO:0016841,GO:0019752,GO:0019842,GO:0030170,GO:0031406,GO:0036094,GO:0043167,GO:0043168,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.3.1.19 ko:K01754 ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230 M00570 R00220,R00996 RC00418,RC02600 ko00000,ko00001,ko00002,ko01000 - - iAPECO1_1312.APECO1_2699 PALP,Thr_dehydrat_C k59_371328_1 1232410.KI421426_gene1458 3.44e-68 231.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJVV@28221|Deltaproteobacteria,43U04@69541|Desulfuromonadales 28221|Deltaproteobacteria V TIGRFAM transporter, hydrophobe amphiphile efflux-1 (HAE1) family - - - ko:K03296,ko:K18138 ko01501,ko01503,map01501,map01503 M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000 2.A.6.2 - - ACR_tran k59_709176_1 575540.Isop_3402 7.04e-112 335.0 COG2006@1|root,COG2006@2|Bacteria,2IYV1@203682|Planctomycetes 203682|Planctomycetes C Domain of unknown function (DUF362) - - - - - - - - - - - - DUF362 k59_709176_2 575540.Isop_3403 1.67e-32 129.0 COG1657@1|root,COG1657@2|Bacteria,2J0IG@203682|Planctomycetes 203682|Planctomycetes I PFAM Prenyltransferase squalene oxidase - - - - - - - - - - - - - k59_256615_1 1229909.NSED_07215 2.06e-96 290.0 COG0358@1|root,arCOG04281@2157|Archaea,41S75@651137|Thaumarchaeota 651137|Thaumarchaeota L DNA primase dnaG - - ko:K02316 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - Toprim_4 k59_1327501_1 1122137.AQXF01000003_gene2426 2.1e-127 368.0 COG0115@1|root,COG0115@2|Bacteria,1MVB0@1224|Proteobacteria,2TR1H@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family ilvE - 2.6.1.42 ko:K00826 ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00036,M00119,M00570 R01090,R01214,R02199,R10991 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_4 k59_1327501_2 1122137.AQXF01000003_gene2427 1.13e-29 108.0 COG1396@1|root,COG1396@2|Bacteria,1RIM2@1224|Proteobacteria,2UAD5@28211|Alphaproteobacteria 28211|Alphaproteobacteria K transcriptional regulators hipB - - - - - - - - - - - HTH_3 k59_479716_1 272134.KB731325_gene580 1.39e-08 57.4 COG1020@1|root,COG1020@2|Bacteria,1G0XE@1117|Cyanobacteria,1H837@1150|Oscillatoriales 1117|Cyanobacteria Q Non-ribosomal peptide synthetase modules and related - - - - - - - - - - - - AMP-binding,AMP-binding_C,Condensation,Methyltransf_12,PP-binding,PilZ k59_479716_2 1894.JOER01000020_gene3829 6.58e-24 106.0 COG1020@1|root,COG1020@2|Bacteria,2GISR@201174|Actinobacteria 201174|Actinobacteria Q Non-ribosomal peptide synthetase modules and related proteins - - - - - - - - - - - - AMP-binding,AMP-binding_C,Beta-lactamase,Condensation,PP-binding k59_1101786_1 1382356.JQMP01000001_gene812 3.42e-57 188.0 COG1294@1|root,COG1294@2|Bacteria,2G6IA@200795|Chloroflexi 200795|Chloroflexi C PFAM cytochrome bd ubiquinol oxidase subunit II - - 1.10.3.14 ko:K00426 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00153 R11325 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.4.3 - - Cyt_bd_oxida_II k59_1101786_2 1382356.JQMP01000001_gene813 1.29e-46 165.0 COG1271@1|root,COG1271@2|Bacteria,2G63Q@200795|Chloroflexi 200795|Chloroflexi C PFAM cytochrome bd ubiquinol oxidase subunit I - - 1.10.3.14 ko:K00425 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00153 R11325 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.4.3 - - Cyt_bd_oxida_I k59_1557990_1 224911.27354274 4.72e-71 223.0 COG1028@1|root,COG1028@2|Bacteria,1Q3GM@1224|Proteobacteria,2U25Q@28211|Alphaproteobacteria,3JTXF@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria IQ KR domain - - - - - - - - - - - - adh_short_C2 k59_762022_1 1552758.NC00_16800 1.26e-75 238.0 COG0635@1|root,COG0635@2|Bacteria,1MU76@1224|Proteobacteria,1RN6I@1236|Gammaproteobacteria,1X32N@135614|Xanthomonadales 135614|Xanthomonadales H Involved in the biosynthesis of porphyrin-containing compound - - - - - - - - - - - - HemN_C,Radical_SAM k59_879683_1 1122929.KB908219_gene1787 2.83e-107 319.0 COG3328@1|root,COG3328@2|Bacteria,1MU4P@1224|Proteobacteria,2TUQT@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Transposase - - - - - - - - - - - - Transposase_mut k59_987662_1 565045.NOR51B_1655 1.02e-46 166.0 COG2234@1|root,COG2234@2|Bacteria,1MV86@1224|Proteobacteria,1RNNQ@1236|Gammaproteobacteria,1J7E4@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S aminopeptidases - - - - - - - - - - - - PA,Peptidase_M28 k59_819337_1 1120963.KB894492_gene1583 8.99e-27 111.0 COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,1RMBS@1236|Gammaproteobacteria,2Q0FH@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria NU COG2804 Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB gspE - - ko:K02454 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - T2SSE k59_1667490_1 1156935.QWE_22756 2.74e-66 224.0 COG0403@1|root,COG1003@1|root,COG0403@2|Bacteria,COG1003@2|Bacteria,1MUDP@1224|Proteobacteria,2TSFF@28211|Alphaproteobacteria,4BB0S@82115|Rhizobiaceae 28211|Alphaproteobacteria E The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor gcvP - 1.4.4.2 ko:K00281,ko:K00283 ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200 M00532 R01221,R03425 RC00022,RC00929,RC02834,RC02880 ko00000,ko00001,ko00002,ko01000 - - - Aminotran_5,GDC-P k59_1667491_1 82654.Pse7367_0767 1.08e-31 124.0 COG0473@1|root,COG0473@2|Bacteria,1GQHJ@1117|Cyanobacteria 1117|Cyanobacteria C PFAM isocitrate isopropylmalate dehydrogenase icd - 1.1.1.41 ko:K00030 ko00020,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010 R00709 RC00114 br01601,ko00000,ko00001,ko00002,ko01000 - - - Iso_dh k59_596060_1 1327971.R9ZYK2_9CAUD 5.63e-38 137.0 4QCM7@10239|Viruses,4QVN1@35237|dsDNA viruses no RNA stage,4QPQ5@28883|Caudovirales 28883|Caudovirales S RNA ligase - - - - - - - - - - - - - k59_198982_1 1380394.JADL01000009_gene3274 2.51e-40 147.0 COG0758@1|root,COG0758@2|Bacteria,1MVF6@1224|Proteobacteria,2TRQE@28211|Alphaproteobacteria,2JPC1@204441|Rhodospirillales 204441|Rhodospirillales LU Rossmann fold nucleotide-binding protein involved in DNA uptake dprA - - ko:K04096 - - - - ko00000 - - - DNA_processg_A k59_1558015_1 525904.Tter_2623 5.62e-61 209.0 COG1060@1|root,COG1060@2|Bacteria,2NP8W@2323|unclassified Bacteria 2|Bacteria H Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2) fbiC - 1.21.98.1,2.5.1.77 ko:K11779,ko:K11784 ko00130,ko00680,ko01110,ko01120,map00130,map00680,map01110,map01120 M00378 R08588,R09396 RC01381,RC02329,RC03002,RC03007 ko00000,ko00001,ko00002,ko01000 - - - CofC,Radical_SAM k59_879701_1 236097.ADG881_2510 5.46e-126 363.0 COG0107@1|root,COG0107@2|Bacteria,1MUS0@1224|Proteobacteria,1RPJQ@1236|Gammaproteobacteria,1XIEI@135619|Oceanospirillales 135619|Oceanospirillales E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit hisF - - ko:K02500 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04558 RC00010,RC01190,RC01943 ko00000,ko00001,ko00002,ko01000 - - - His_biosynth k59_1159724_1 1211777.BN77_p230001 1.71e-68 218.0 COG0010@1|root,COG0010@2|Bacteria,1MVFH@1224|Proteobacteria,2TQSZ@28211|Alphaproteobacteria,4BEH3@82115|Rhizobiaceae 28211|Alphaproteobacteria E Arginase family - - 3.5.3.11 ko:K01480 ko00330,ko01100,map00330,map01100 M00133 R01157 RC00024,RC00329 ko00000,ko00001,ko00002,ko01000 - - - Arginase k59_1270793_1 491952.Mar181_2521 1.05e-105 317.0 COG0161@1|root,COG0161@2|Bacteria,1MU2N@1224|Proteobacteria,1RNW9@1236|Gammaproteobacteria,1XI3H@135619|Oceanospirillales 135619|Oceanospirillales H Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family - - - - - - - - - - - - Aminotran_3 k59_479748_1 1004785.AMBLS11_12225 5.36e-26 106.0 COG1066@1|root,COG1066@2|Bacteria,1MUJQ@1224|Proteobacteria,1RN2E@1236|Gammaproteobacteria,4659K@72275|Alteromonadaceae 1236|Gammaproteobacteria O DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function radA GO:0000725,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009314,GO:0009628,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363 - ko:K04485 - - - - ko00000,ko03400 - - - AAA_25,ATPase,ChlI k59_479748_2 1033802.SSPSH_002045 1.03e-36 136.0 COG4536@1|root,COG4536@2|Bacteria,1NZ99@1224|Proteobacteria,1RNCE@1236|Gammaproteobacteria 1236|Gammaproteobacteria P Mg2 and Co2 transporter CorB yfjD GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - - - - - - - - - - CBS,CorC_HlyC,DUF21 k59_762048_1 1415778.JQMM01000001_gene1832 2.14e-27 115.0 COG1643@1|root,COG1643@2|Bacteria,1MUEQ@1224|Proteobacteria,1RMU1@1236|Gammaproteobacteria,1J5AR@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L COG1643 HrpA-like helicases hrpA GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0006139,GO:0006396,GO:0006397,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0034641,GO:0042623,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0070035,GO:0071704,GO:0090304,GO:0140098,GO:1901360 3.6.4.13 ko:K03578 - - - - ko00000,ko01000 - - - DEAD,DUF3418,HA2,Helicase_C,OB_NTP_bind k59_256675_1 1125863.JAFN01000001_gene769 2.63e-101 317.0 COG0542@1|root,COG0542@2|Bacteria,1MURH@1224|Proteobacteria,42M9S@68525|delta/epsilon subdivisions,2WJSZ@28221|Deltaproteobacteria 28221|Deltaproteobacteria O Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE clpB - - ko:K03695 ko04213,map04213 - - - ko00000,ko00001,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N k59_424188_1 316407.85675232 9.08e-148 422.0 COG0714@1|root,COG0714@2|Bacteria,1QDUZ@1224|Proteobacteria,1RQGT@1236|Gammaproteobacteria,3XN4P@561|Escherichia 1236|Gammaproteobacteria S ATPase activity yehL - - - - - - - - - - - AAA_5 k59_819373_1 219305.MCAG_02052 1.52e-06 56.2 COG2133@1|root,COG3291@1|root,COG3507@1|root,COG3828@1|root,COG2133@2|Bacteria,COG3291@2|Bacteria,COG3507@2|Bacteria,COG3828@2|Bacteria,2GJFY@201174|Actinobacteria,4D8ZK@85008|Micromonosporales 201174|Actinobacteria G Protein of unknown function (DUF1349) - - - - - - - - - - - - CBM_6,DUF1349,GSDH,PKD,ThuA k59_1501089_1 1229909.NSED_05170 4.81e-63 210.0 COG0441@1|root,arCOG00401@2157|Archaea,41S9K@651137|Thaumarchaeota 651137|Thaumarchaeota J Belongs to the class-II aminoacyl-tRNA synthetase family thrS - 6.1.1.3 ko:K01868 ko00970,map00970 M00359,M00360 R03663 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,tRNA-Thr_ED,tRNA-synt_2b k59_1501089_2 1229909.NSED_03015 8.83e-15 68.9 arCOG08710@1|root,arCOG08710@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_371414_1 740709.A10D4_04190 1.68e-57 194.0 COG4805@1|root,COG4805@2|Bacteria,1MUBX@1224|Proteobacteria,1RMT7@1236|Gammaproteobacteria,2QEZK@267893|Idiomarinaceae 1236|Gammaproteobacteria S Bacterial protein of unknown function (DUF885) - - - - - - - - - - - - DUF885 k59_314691_1 551275.KB899544_gene1347 6.63e-12 68.2 COG0477@1|root,COG2814@2|Bacteria,1NU31@1224|Proteobacteria,2U5M0@28211|Alphaproteobacteria,440UM@69657|Hyphomonadaceae 28211|Alphaproteobacteria EGP Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 k59_314691_2 887062.HGR_13814 7.21e-06 49.3 COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,2VH5A@28216|Betaproteobacteria,4AA7M@80864|Comamonadaceae 28216|Betaproteobacteria C PFAM FAD linked oxidase domain protein - - - - - - - - - - - - FAD-oxidase_C,FAD_binding_4 k59_1048926_1 215803.DB30_8544 1.22e-26 114.0 COG0515@1|root,COG3899@1|root,COG4191@1|root,COG0515@2|Bacteria,COG3899@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,43BX5@68525|delta/epsilon subdivisions,2X77Z@28221|Deltaproteobacteria,2YY1C@29|Myxococcales 28221|Deltaproteobacteria KLT Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - - - - - - - - - - AAA_16,GAF,GAF_2,HATPase_c,Pkinase k59_199037_1 1122137.AQXF01000003_gene2289 6.8e-06 47.0 COG0472@1|root,COG0472@2|Bacteria,1MUTK@1224|Proteobacteria,2TRUG@28211|Alphaproteobacteria 28211|Alphaproteobacteria M First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan mraY - 2.7.8.13 ko:K01000 ko00550,ko01100,ko01502,map00550,map01100,map01502 - R05629,R05630 RC00002,RC02753 ko00000,ko00001,ko01000,ko01011 9.B.146 - - Glycos_transf_4,MraY_sig1 k59_199037_2 1122137.AQXF01000003_gene2290 1.67e-66 216.0 COG0771@1|root,COG0771@2|Bacteria,1MVYD@1224|Proteobacteria,2TTE8@28211|Alphaproteobacteria 28211|Alphaproteobacteria M Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) murD - 6.3.2.9 ko:K01925 ko00471,ko00550,ko01100,map00471,map00550,map01100 - R02783 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase_C,Mur_ligase_M k59_1387958_1 795666.MW7_0915 3.04e-127 400.0 COG0587@1|root,COG0587@2|Bacteria,1MUIF@1224|Proteobacteria,2VH3F@28216|Betaproteobacteria,1K1A9@119060|Burkholderiaceae 28216|Betaproteobacteria L DNA polymerase dnaE - 2.7.7.7 ko:K02337 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon k59_31873_2 998674.ATTE01000001_gene594 3.15e-64 209.0 COG1300@1|root,COG1300@2|Bacteria,1Q1GN@1224|Proteobacteria,1RR61@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Membrane - - - - - - - - - - - - SpoIIM k59_256724_1 314287.GB2207_09511 2.76e-114 339.0 COG0174@1|root,COG0174@2|Bacteria,1MUGQ@1224|Proteobacteria,1RMD1@1236|Gammaproteobacteria,1J4KI@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E glutamine synthetase glnA - 6.3.1.2 ko:K01915 ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 - R00253 RC00010,RC02798 ko00000,ko00001,ko01000,ko04147 - - iJN746.PP_5046 Gln-synt_C,Gln-synt_N k59_256724_2 1168034.FH5T_12285 3.16e-138 398.0 COG0174@1|root,COG0174@2|Bacteria,4NGG2@976|Bacteroidetes 976|Bacteroidetes E glutamine synthetase glnII - 6.3.1.2 ko:K01915 ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 - R00253 RC00010,RC02798 ko00000,ko00001,ko01000,ko04147 - - - Gln-synt_C,Gln-synt_N k59_1270831_1 288000.BBta_6814 4.79e-66 226.0 COG1020@1|root,COG1020@2|Bacteria,1QK4F@1224|Proteobacteria,2TRUN@28211|Alphaproteobacteria,3JQV9@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria Q Phosphopantetheine attachment site - - - - - - - - - - - - AMP-binding,AMP-binding_C,Condensation,PP-binding k59_88906_1 349521.HCH_01933 1.33e-31 124.0 COG0795@1|root,COG0795@2|Bacteria,1MUF2@1224|Proteobacteria,1RMN5@1236|Gammaproteobacteria,1XHM6@135619|Oceanospirillales 135619|Oceanospirillales S Permease lptF - - ko:K07091 ko02010,map02010 M00320 - - ko00000,ko00001,ko00002,ko02000 1.B.42.1 - - YjgP_YjgQ k59_371454_1 991905.SL003B_1604 1.16e-36 132.0 COG0714@1|root,COG0714@2|Bacteria,1MV5I@1224|Proteobacteria,2TREB@28211|Alphaproteobacteria,4BPS0@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria S AAA domain (dynein-related subfamily) MA20_09400 - - - - - - - - - - - AAA_5 k59_256733_1 436308.Nmar_1080 5.62e-43 141.0 COG1436@1|root,arCOG04102@2157|Archaea,41T76@651137|Thaumarchaeota 651137|Thaumarchaeota C ATP synthase (F/14-kDa) subunit - - - ko:K02122 ko00190,ko01100,map00190,map01100 M00159 - - ko00000,ko00001,ko00002 3.A.2.2,3.A.2.3 - - ATP-synt_F k59_256733_2 1229909.NSED_06295 2.54e-23 90.9 arCOG08700@1|root,arCOG08700@2157|Archaea,41SV2@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1159795_1 571166.KI421509_gene4088 3.9e-84 265.0 COG5476@1|root,COG5476@2|Bacteria,1MX4P@1224|Proteobacteria,2TS1C@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Involved in peptidolytic degradation of cyclic heptapeptide hepatotoxin microcystin (MC) - - - - - - - - - - - - DUF1485,MlrC_C k59_143312_1 314271.RB2654_20588 1.12e-28 108.0 COG1393@1|root,COG1393@2|Bacteria,1MZ4Z@1224|Proteobacteria,2U70U@28211|Alphaproteobacteria 28211|Alphaproteobacteria P arsenate reductase arsC - 1.20.4.1 ko:K00537 - - - - ko00000,ko01000 - - - ArsC k59_143312_2 1122137.AQXF01000001_gene3211 8.02e-106 322.0 COG0534@1|root,COG0534@2|Bacteria,1MV6B@1224|Proteobacteria,2TSKZ@28211|Alphaproteobacteria 28211|Alphaproteobacteria V COG0534 Na -driven multidrug efflux pump dinF - - ko:K03327 - - - - ko00000,ko02000 2.A.66.1 - - MatE k59_1159796_1 176299.Atu5260 2.03e-77 248.0 COG1680@1|root,COG1680@2|Bacteria,1PDR2@1224|Proteobacteria,2U487@28211|Alphaproteobacteria,4BC3V@82115|Rhizobiaceae 28211|Alphaproteobacteria V Beta-lactamase - - - - - - - - - - - - Beta-lactamase k59_1778092_1 1298593.TOL_0436 8.21e-29 120.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1XIWS@135619|Oceanospirillales 135619|Oceanospirillales V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_988796_2 1144305.PMI02_04200 3.69e-48 159.0 COG1981@1|root,COG1981@2|Bacteria,1RHGS@1224|Proteobacteria,2U987@28211|Alphaproteobacteria,2K4J9@204457|Sphingomonadales 204457|Sphingomonadales S membrane - - - ko:K08973 - - - - ko00000 - - - UPF0093 k59_988796_3 1122137.AQXF01000001_gene3247 2.97e-114 333.0 COG0407@1|root,COG0407@2|Bacteria,1MUG1@1224|Proteobacteria,2TQQV@28211|Alphaproteobacteria 28211|Alphaproteobacteria H Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III hemE GO:0003674,GO:0003824,GO:0004853,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.1.37 ko:K01599 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R03197,R04972 RC00872 ko00000,ko00001,ko00002,ko01000 - - - URO-D k59_1779043_1 316407.85677026 6.19e-240 661.0 COG2826@1|root,COG2826@2|Bacteria,1PP49@1224|Proteobacteria,1RN7B@1236|Gammaproteobacteria,3XQB0@561|Escherichia 1236|Gammaproteobacteria L Transposase insI for insertion sequence element insI GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003824,GO:0004803,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006310,GO:0006313,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0030983,GO:0032135,GO:0032196,GO:0032991,GO:0032993,GO:0034641,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363 - - - - - - - - - - HTH_38,rve k59_1613947_1 745014.OMB55_00021440 1.8e-50 183.0 COG4774@1|root,COG4774@2|Bacteria,1MX2G@1224|Proteobacteria,1RYSK@1236|Gammaproteobacteria,1J7TN@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P COG1629 Outer membrane receptor proteins, mostly Fe transport - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_820886_1 1463821.JOGR01000021_gene3093 2.14e-30 116.0 COG0745@1|root,COG0745@2|Bacteria,2GKYV@201174|Actinobacteria,4EZQQ@85014|Glycomycetales 201174|Actinobacteria T Transcriptional regulatory protein, C terminal - - - - - - - - - - - - Response_reg,Trans_reg_C k59_820886_2 1123229.AUBC01000006_gene1032 1.55e-34 137.0 COG0642@1|root,COG0642@2|Bacteria,1MX6R@1224|Proteobacteria,2TS9N@28211|Alphaproteobacteria,3JRDW@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria T Histidine kinase feuQ - - - - - - - - - - - 2CSK_N,HATPase_c k59_200542_1 1123261.AXDW01000005_gene2656 1.72e-08 62.0 COG0457@1|root,COG0457@2|Bacteria,1MXSS@1224|Proteobacteria,1S157@1236|Gammaproteobacteria,1X48H@135614|Xanthomonadales 135614|Xanthomonadales S Tetratricopeptide repeat - - - - - - - - - - - - - k59_1502638_1 1120956.JHZK01000015_gene2999 1.64e-84 263.0 COG0389@1|root,COG0389@2|Bacteria,1MUUH@1224|Proteobacteria,2TSJN@28211|Alphaproteobacteria,1JN7I@119043|Rhodobiaceae 28211|Alphaproteobacteria L DNA polymerase IV dinB GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0050896,GO:0051716,GO:0071496 2.7.7.7 ko:K02346 - - - - ko00000,ko01000,ko03400 - - - IMS,IMS_C k59_820891_1 1122137.AQXF01000001_gene2504 4.67e-95 295.0 COG0529@1|root,COG2895@1|root,COG0529@2|Bacteria,COG2895@2|Bacteria,1MUD9@1224|Proteobacteria,2TQNJ@28211|Alphaproteobacteria 28211|Alphaproteobacteria P Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN NodQ subfamily cysC - 2.7.1.25,2.7.7.4 ko:K00955,ko:K00956 ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130 M00176,M00596 R00509,R00529,R04928,R04929 RC00002,RC00078,RC02809,RC02889 ko00000,ko00001,ko00002,ko01000 - - - APS_kinase,GTP_EFTU,GTP_EFTU_D2 k59_1050398_1 1268239.PALB_19690 7.66e-43 154.0 COG0845@1|root,COG0845@2|Bacteria,1MUFW@1224|Proteobacteria,1RQJ9@1236|Gammaproteobacteria,2Q0C6@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - ko:K03585 ko01501,ko01503,map01501,map01503 M00646,M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000,ko03036 2.A.6.2,8.A.1.6 - - HlyD_D23 k59_1050398_2 572477.Alvin_2517 5.31e-38 142.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1WW0R@135613|Chromatiales 135613|Chromatiales V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K18138 ko01501,ko01503,map01501,map01503 M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000 2.A.6.2 - - ACR_tran k59_1668682_1 1121943.KB899989_gene3288 1.72e-88 272.0 COG2017@1|root,COG2017@2|Bacteria,1MVMN@1224|Proteobacteria,1RNZN@1236|Gammaproteobacteria,1XJKW@135619|Oceanospirillales 135619|Oceanospirillales G Converts alpha-aldose to the beta-anomer galM - 5.1.3.3 ko:K01785 ko00010,ko00052,ko01100,ko01110,ko01120,ko01130,map00010,map00052,map01100,map01110,map01120,map01130 M00632 R01602,R10619 RC00563 ko00000,ko00001,ko00002,ko01000 - - - Aldose_epim k59_1389524_1 1144325.PMI22_04418 1.65e-95 300.0 COG1032@1|root,COG1032@2|Bacteria,1MUG3@1224|Proteobacteria,1RN9V@1236|Gammaproteobacteria 1236|Gammaproteobacteria C UPF0313 protein ygiQ - - - - - - - - - - - DUF3362,Radical_SAM,Radical_SAM_N k59_1227692_2 1380600.AUYN01000009_gene1739 3.5e-56 177.0 2AFHA@1|root,315HT@2|Bacteria,4NQ5F@976|Bacteroidetes,1I2SM@117743|Flavobacteriia 976|Bacteroidetes S S23 ribosomal protein - - - - - - - - - - - - 23S_rRNA_IVP k59_211150_1 1449063.JMLS01000030_gene476 9.62e-11 67.8 COG1793@1|root,COG1793@2|Bacteria,1V5A5@1239|Firmicutes,4HHAK@91061|Bacilli,26UIH@186822|Paenibacillaceae 91061|Bacilli L DNA ligase - - 6.5.1.1,6.5.1.6,6.5.1.7 ko:K10747 ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430 - R00381,R00382,R10822,R10823 RC00005 ko00000,ko00001,ko01000,ko03032,ko03400 - - - DNA_ligase_A_M k59_1112717_1 1122137.AQXF01000002_gene340 2.92e-73 243.0 COG1391@1|root,COG1391@2|Bacteria,1MU4I@1224|Proteobacteria,2TRY7@28211|Alphaproteobacteria 28211|Alphaproteobacteria H Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell glnE GO:0000820,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006521,GO:0008150,GO:0008882,GO:0010565,GO:0016740,GO:0016772,GO:0016779,GO:0019222,GO:0031323,GO:0033238,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0062012,GO:0065007,GO:0070566,GO:0080090 2.7.7.42,2.7.7.89 ko:K00982 - - - - ko00000,ko01000 - - - GlnD_UR_UTase,GlnE k59_43472_1 1122137.AQXF01000001_gene3224 9.21e-67 212.0 COG1420@1|root,COG1420@2|Bacteria,1MVX4@1224|Proteobacteria,2TRUF@28211|Alphaproteobacteria 28211|Alphaproteobacteria K Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons hrcA - - ko:K03705 - - - - ko00000,ko03000 - - - HrcA,HrcA_DNA-bdg k59_43472_2 522373.Smlt0532 2.27e-17 76.6 COG2764@1|root,COG2764@2|Bacteria,1N0S4@1224|Proteobacteria,1SA7P@1236|Gammaproteobacteria,1X7Y5@135614|Xanthomonadales 135614|Xanthomonadales S 3-demethylubiquinone-9 3-methyltransferase - - - ko:K04750 - - - - ko00000 - - - 3-dmu-9_3-mt k59_1227700_1 497321.C664_10892 4.62e-99 298.0 COG0133@1|root,COG0133@2|Bacteria,1MUS8@1224|Proteobacteria,2VHV3@28216|Betaproteobacteria,2KUYW@206389|Rhodocyclales 206389|Rhodocyclales E The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine trpB - 4.2.1.20 ko:K01696 ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230 M00023 R00674,R02340,R02722 RC00209,RC00210,RC00700,RC00701,RC02868 ko00000,ko00001,ko00002,ko01000 - - - PALP k59_1059905_1 2340.JV46_19560 1.12e-77 253.0 COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MU0R@1224|Proteobacteria,1RP3T@1236|Gammaproteobacteria,1J5GE@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria G Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate ppsA GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006094,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008986,GO:0009058,GO:0009987,GO:0016051,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016781,GO:0019318,GO:0019319,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046364,GO:0046872,GO:0071704,GO:1901576 2.7.9.2 ko:K01007 ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200 M00173,M00374 R00199 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - iEcE24377_1341.EcE24377A_1919,iYL1228.KPN_02160 PEP-utilizers,PEP-utilizers_C,PPDK_N k59_99359_1 436308.Nmar_0348 5.43e-108 343.0 COG0086@1|root,arCOG04256@2157|Archaea,arCOG04257@2157|Archaea,41SB2@651137|Thaumarchaeota 651137|Thaumarchaeota K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoA2 - 2.7.7.6 ko:K03041 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00184 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021 - - - RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5 k59_1570556_1 1144305.PMI02_00240 6.11e-82 251.0 COG1609@1|root,COG1609@2|Bacteria,1MVUR@1224|Proteobacteria,2U0SC@28211|Alphaproteobacteria,2K0F6@204457|Sphingomonadales 204457|Sphingomonadales K LacI family - - - ko:K02529 - - - - ko00000,ko03000 - - - LacI,Peripla_BP_3 k59_1570556_2 1081640.AGFU01000011_gene1257 2.86e-18 85.9 COG2721@1|root,COG2721@2|Bacteria,1MU9V@1224|Proteobacteria,2TTDT@28211|Alphaproteobacteria,2K15R@204457|Sphingomonadales 204457|Sphingomonadales G D-galactarate dehydratase / Altronate hydrolase, C terminus - - 4.2.1.7 ko:K01685 ko00040,ko01100,map00040,map01100 M00631 R01540 RC00543 ko00000,ko00001,ko00002,ko01000 - - - GD_AH_C,SAF k59_1112721_1 1122137.AQXF01000004_gene1718 6.42e-20 85.9 COG0122@1|root,COG0122@2|Bacteria,1MX9C@1224|Proteobacteria,2TVJ7@28211|Alphaproteobacteria 28211|Alphaproteobacteria L 3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase alkA - 3.2.2.21 ko:K01247 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - HhH-GPD k59_721925_1 1122137.AQXF01000001_gene3090 3.94e-107 317.0 COG2382@1|root,COG2382@2|Bacteria,1MXJN@1224|Proteobacteria,2TRGT@28211|Alphaproteobacteria 28211|Alphaproteobacteria P Domain of unknown function (DUF3327) fes - - ko:K07214 - - - - ko00000 - - - DUF3327,Esterase k59_268802_1 1150469.RSPPHO_01516 3.19e-97 294.0 COG0840@1|root,COG0840@2|Bacteria,1P0ZT@1224|Proteobacteria,2TUX8@28211|Alphaproteobacteria,2JPZN@204441|Rhodospirillales 204441|Rhodospirillales NT methyl-accepting chemotaxis protein - - - - - - - - - - - - MCPsignal,dCache_1 k59_1735862_1 314225.ELI_08535 1.64e-127 377.0 COG2239@1|root,COG2239@2|Bacteria,1MW24@1224|Proteobacteria,2TRWK@28211|Alphaproteobacteria,2K0AK@204457|Sphingomonadales 204457|Sphingomonadales P Acts as a magnesium transporter mgtE - - ko:K06213 - - - - ko00000,ko02000 1.A.26.1 - - CBS,MgtE,MgtE_N k59_490465_1 1411685.U062_01414 8.26e-85 272.0 COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,1RNJI@1236|Gammaproteobacteria,1J4RW@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L DNA helicase uvrD GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006289,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009628,GO:0009987,GO:0015616,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017116,GO:0022607,GO:0031297,GO:0032392,GO:0032508,GO:0033554,GO:0034641,GO:0034645,GO:0042623,GO:0042802,GO:0043142,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0045005,GO:0046483,GO:0050896,GO:0051259,GO:0051260,GO:0051276,GO:0051716,GO:0065003,GO:0070035,GO:0070581,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360,GO:1901576 3.6.4.12 ko:K03657 ko03420,ko03430,map03420,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - UvrD-helicase,UvrD_C k59_772822_1 1121374.KB891576_gene711 1.93e-106 327.0 COG5265@1|root,COG5265@2|Bacteria,1NSKS@1224|Proteobacteria,1T1W9@1236|Gammaproteobacteria 1236|Gammaproteobacteria V COG5265 ABC-type transport system involved in Fe-S cluster assembly permease and ATPase components atmA - - ko:K06147 - - - - ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran k59_1735868_2 717774.Marme_4063 5.51e-29 115.0 COG2253@1|root,COG2253@2|Bacteria,1MWST@1224|Proteobacteria,1RMAN@1236|Gammaproteobacteria,1XJ3K@135619|Oceanospirillales 135619|Oceanospirillales S Nucleotidyl transferase AbiEii toxin, Type IV TA system - - - - - - - - - - - - AbiEii k59_1513058_1 1121405.dsmv_2651 8.45e-41 149.0 COG5421@1|root,COG5421@2|Bacteria,1R3NX@1224|Proteobacteria,42QDV@68525|delta/epsilon subdivisions,2WIRQ@28221|Deltaproteobacteria,2MN1S@213118|Desulfobacterales 68525|delta/epsilon subdivisions L PFAM transposase IS4 family protein - - - - - - - - - - - - DDE_Tnp_1 k59_1337975_1 316407.85674519 1.81e-181 509.0 28HWK@1|root,2Z82H@2|Bacteria,1MVDT@1224|Proteobacteria,1RQ61@1236|Gammaproteobacteria,3XNC1@561|Escherichia 1236|Gammaproteobacteria S response to peptide yaiW GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0009279,GO:0010033,GO:0010243,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031240,GO:0031975,GO:0042221,GO:0044424,GO:0044425,GO:0044444,GO:0044462,GO:0044464,GO:0050896,GO:0071944,GO:0098552,GO:1901652,GO:1901698,GO:1901700 - - - - - - - - - - DUF1615 k59_1059916_1 338963.Pcar_3001 6.39e-121 379.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MQ0@68525|delta/epsilon subdivisions,2WJ2A@28221|Deltaproteobacteria,43SE5@69541|Desulfuromonadales 28221|Deltaproteobacteria V AcrB/AcrD/AcrF family - - - - - - - - - - - - ACR_tran k59_772826_1 580340.Tlie_1798 2.51e-45 160.0 COG1840@1|root,COG1840@2|Bacteria,3TBR1@508458|Synergistetes 508458|Synergistetes P PFAM extracellular solute-binding protein family 1 - - - ko:K02012 ko02010,map02010 M00190 - - ko00000,ko00001,ko00002,ko02000 3.A.1.10 - - SBP_bac_6 k59_1171694_2 644283.Micau_5124 8.5e-73 235.0 COG0766@1|root,COG0766@2|Bacteria,2GJPW@201174|Actinobacteria,4DAAS@85008|Micromonosporales 201174|Actinobacteria M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine murA GO:0008150,GO:0040007 2.5.1.7 ko:K00790 ko00520,ko00550,ko01100,map00520,map00550,map01100 - R00660 RC00350 ko00000,ko00001,ko01000,ko01011 - - - EPSP_synthase k59_383565_1 1223410.KN050846_gene1421 3.89e-96 281.0 COG0221@1|root,COG0221@2|Bacteria,4NGBU@976|Bacteroidetes,1HX3R@117743|Flavobacteriia 976|Bacteroidetes C Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions ppa - 3.6.1.1 ko:K01507 ko00190,map00190 - - - ko00000,ko00001,ko01000 - - - Pyrophosphatase k59_326964_1 1283299.AUKG01000002_gene4334 8.15e-66 209.0 COG0074@1|root,COG0074@2|Bacteria,2GK00@201174|Actinobacteria,4CSIF@84995|Rubrobacteria 84995|Rubrobacteria C Succinyl-CoA ligase like flavodoxin domain - - - - - - - - - - - - CoA_binding,Succ_CoA_lig k59_326964_2 469383.Cwoe_4214 2.66e-46 160.0 COG0045@1|root,COG0045@2|Bacteria,2GKSB@201174|Actinobacteria 201174|Actinobacteria C Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit - - 6.2.1.18 ko:K15232 ko00720,ko01100,ko01120,ko01200,map00720,map01100,map01120,map01200 M00173 R01322 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000 - - - ATP-grasp_2 k59_153907_1 713587.THITH_01885 1.8e-132 405.0 COG0610@1|root,COG0610@2|Bacteria,1MU96@1224|Proteobacteria,1RP2Q@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Subunit R is required for both nuclease and ATPase activities, but not for modification - - 3.1.21.3 ko:K01153 - - - - ko00000,ko01000,ko02048 - - - DUF3387,HSDR_N,ResIII k59_721949_1 436308.Nmar_0730 1.13e-133 394.0 arCOG08764@1|root,arCOG08798@2157|Archaea,41SZ3@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_891842_1 1168034.FH5T_20550 1.22e-63 208.0 COG2223@1|root,COG2223@2|Bacteria,4NHX9@976|Bacteroidetes,2FZ04@200643|Bacteroidia 976|Bacteroidetes P Major Facilitator Superfamily - - - ko:K08177 - - - - ko00000,ko02000 2.A.1.11 - - MFS_1 k59_942719_1 1353276.JADR01000001_gene473 2.46e-32 125.0 COG2304@1|root,COG2304@2|Bacteria,4NFX3@976|Bacteroidetes,1HY6K@117743|Flavobacteriia 976|Bacteroidetes M von Willebrand factor, type A yfbK - - ko:K07114 - - - - ko00000,ko02000 1.A.13.2.2,1.A.13.2.3 - - CarbopepD_reg_2,DUF3520,Plug,TSP_3,VWA,vWF_A k59_942719_2 983544.Lacal_2321 1.1e-39 144.0 COG4799@1|root,COG4799@2|Bacteria,4NEMJ@976|Bacteroidetes,1HY0V@117743|Flavobacteriia 976|Bacteroidetes I Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) accD5 - - - - - - - - - - - Carboxyl_trans k59_1451441_1 1122137.AQXF01000006_gene772 9.12e-37 132.0 COG0805@1|root,COG0805@2|Bacteria,1MVAY@1224|Proteobacteria,2TTIX@28211|Alphaproteobacteria 28211|Alphaproteobacteria U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides tatC - - ko:K03118 ko03060,ko03070,map03060,map03070 M00336 - - ko00000,ko00001,ko00002,ko02044 2.A.64 - - TatC k59_1451441_2 1122137.AQXF01000006_gene773 8.59e-40 136.0 COG1826@1|root,COG1826@2|Bacteria 2|Bacteria U protein secretion tatB GO:0003674,GO:0005215 - ko:K03116,ko:K03117 ko03060,ko03070,map03060,map03070 M00336 - - ko00000,ko00001,ko00002,ko02044 2.A.64 - - MttA_Hcf106 k59_1451441_3 34007.IT40_21130 5.25e-14 68.6 COG1826@1|root,COG1826@2|Bacteria,1NGDP@1224|Proteobacteria,2V4P0@28211|Alphaproteobacteria,2PXHV@265|Paracoccus 28211|Alphaproteobacteria U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system tatA - - ko:K03116 ko03060,ko03070,map03060,map03070 M00336 - - ko00000,ko00001,ko00002,ko02044 2.A.64 - - MttA_Hcf106 k59_1788068_1 1197477.IA57_00515 3.6e-152 446.0 COG0272@1|root,COG0272@2|Bacteria,4NE2X@976|Bacteroidetes,1HXSG@117743|Flavobacteriia 976|Bacteroidetes L DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA ligA GO:0003674,GO:0003824,GO:0003909,GO:0003911,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016874,GO:0016886,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360 6.5.1.2 ko:K01972 ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430 - R00382 RC00005 ko00000,ko00001,ko01000,ko03032,ko03400 - - - BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5 k59_434773_1 338969.Rfer_1144 4.12e-148 445.0 COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,2VH8J@28216|Betaproteobacteria,4A9KK@80864|Comamonadaceae 28216|Betaproteobacteria P heavy metal translocating P-type ATPase actP - 3.6.3.54 ko:K17686 ko01524,ko04016,map01524,map04016 - R00086 RC00002 ko00000,ko00001,ko01000 3.A.3.5 - - E1-E2_ATPase,Hydrolase,YHS k59_1227729_1 330214.NIDE3344 3.11e-70 229.0 COG0265@1|root,COG0750@1|root,COG0265@2|Bacteria,COG0750@2|Bacteria,3J0VW@40117|Nitrospirae 40117|Nitrospirae O Trypsin - - 3.4.21.107 ko:K04771 ko01503,ko02020,map01503,map02020 M00728 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 - - - PDZ_2,Trypsin_2 k59_1623176_1 208439.AJAP_27675 2.03e-30 122.0 COG3214@1|root,COG3214@2|Bacteria,2GJM7@201174|Actinobacteria,4E01A@85010|Pseudonocardiales 201174|Actinobacteria S Winged helix DNA-binding domain - - - ko:K09927 - - - - ko00000 - - - HTH_42 k59_1623177_1 1429046.RR21198_0739 1.17e-10 67.0 COG2141@1|root,COG2141@2|Bacteria,2GJAN@201174|Actinobacteria,4FVWR@85025|Nocardiaceae 201174|Actinobacteria C COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - - - - - - - - - - Bac_luciferase k59_891850_1 436308.Nmar_1734 9.13e-38 131.0 COG5615@1|root,arCOG05392@2157|Archaea,41T4B@651137|Thaumarchaeota 651137|Thaumarchaeota S Copper resistance protein D - - - - - - - - - - - - CopD k59_891850_2 436308.Nmar_1733 2.51e-136 397.0 COG0430@1|root,arCOG04125@2157|Archaea,41T1K@651137|Thaumarchaeota 651137|Thaumarchaeota J Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps (A) adenylation of the enzyme by ATP rtcA - 6.5.1.4 ko:K01974 - - - - ko00000,ko01000 - - - RTC k59_891850_3 1229909.NSED_09220 3.49e-86 256.0 COG1056@1|root,arCOG00972@2157|Archaea,41T7B@651137|Thaumarchaeota 651137|Thaumarchaeota H Cytidylyltransferase-like - - 2.7.7.1 ko:K00952 ko00760,ko01100,map00760,map01100 - R00137,R03005 RC00002 ko00000,ko00001,ko01000 - - - CTP_transf_like k59_1789327_1 1229909.NSED_06915 3.76e-70 216.0 COG1909@1|root,arCOG04076@2157|Archaea,41SNQ@651137|Thaumarchaeota 651137|Thaumarchaeota S Belongs to the UPF0218 family - - - ko:K09735 - - - - ko00000 - - - DUF359 k59_384755_1 436308.Nmar_1291 6.7e-127 370.0 COG4992@1|root,arCOG00914@2157|Archaea,41SC8@651137|Thaumarchaeota 651137|Thaumarchaeota E Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family lysJ - - ko:K05830 ko00220,ko00300,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01130,map01210,map01230 M00031,M00763 R09778,R10932 RC00006,RC00062 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 k59_1061096_1 1121949.AQXT01000002_gene2094 3.14e-69 235.0 COG1629@1|root,COG4771@2|Bacteria,1N6JG@1224|Proteobacteria,2TSK9@28211|Alphaproteobacteria,43WCB@69657|Hyphomonadaceae 28211|Alphaproteobacteria P Outer membrane receptor - - - - - - - - - - - - CarboxypepD_reg,Plug,TonB_dep_Rec k59_1624291_1 1121127.JAFA01000011_gene3780 6.78e-05 51.2 COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2VI0I@28216|Betaproteobacteria,1JZTX@119060|Burkholderiaceae 28216|Betaproteobacteria IQ PFAM AMP-dependent synthetase and ligase - - 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding,AMP-binding_C k59_100428_1 391603.FBALC1_16507 7.32e-65 202.0 COG0299@1|root,COG0299@2|Bacteria,4NNZP@976|Bacteroidetes,1I19R@117743|Flavobacteriia 976|Bacteroidetes F Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate purN - 2.1.2.2 ko:K11175 ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130 M00048 R04325,R04326 RC00026,RC00197,RC01128 ko00000,ko00001,ko00002,ko01000 - - - Formyl_trans_N k59_100428_2 411154.GFO_3382 2.5e-43 141.0 COG0236@1|root,COG0236@2|Bacteria,4NS6C@976|Bacteroidetes,1I3VI@117743|Flavobacteriia 976|Bacteroidetes IQ Carrier of the growing fatty acid chain in fatty acid biosynthesis acpP - - ko:K02078 - - - - ko00000,ko00001 - - - PP-binding k59_1624298_1 1122137.AQXF01000002_gene94 2.43e-70 227.0 COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,2TR6Q@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Belongs to the DEAD box helicase family rhlE - 3.6.4.13 ko:K03732,ko:K11927 ko03018,map03018 M00394 - - ko00000,ko00001,ko00002,ko01000,ko03019 - - - DEAD,Helicase_C k59_893128_1 362976.HQ_2208A 1.91e-23 103.0 COG3174@1|root,arCOG04203@2157|Archaea,2XT0W@28890|Euryarchaeota,23UFT@183963|Halobacteria 183963|Halobacteria P Domain of unknown function (DUF4010) - - - - - - - - - - - - DUF4010,MgtC k59_609770_1 314225.ELI_03140 4.58e-38 135.0 COG2301@1|root,COG2301@2|Bacteria,1MW0A@1224|Proteobacteria,2TTC0@28211|Alphaproteobacteria,2K2E1@204457|Sphingomonadales 204457|Sphingomonadales G Belongs to the HpcH HpaI aldolase family - - 4.1.3.34 ko:K01644 ko02020,map02020 - R00362 RC00067,RC01118 ko00000,ko00001,ko01000 - - - HpcH_HpaI k59_609770_2 1144305.PMI02_04350 3.15e-46 160.0 COG0427@1|root,COG0427@2|Bacteria,1MUGE@1224|Proteobacteria,2TZDG@28211|Alphaproteobacteria,2K2PK@204457|Sphingomonadales 204457|Sphingomonadales C Acetyl-CoA hydrolase/transferase N-terminal domain - - - - - - - - - - - - AcetylCoA_hyd_C,AcetylCoA_hydro k59_491645_1 595537.Varpa_2715 1.77e-33 131.0 COG1530@1|root,COG1530@2|Bacteria,1MV65@1224|Proteobacteria,2VI3N@28216|Betaproteobacteria,4AA30@80864|Comamonadaceae 28216|Betaproteobacteria J ribonuclease, Rne Rng family cafA - - ko:K08301 - - - - ko00000,ko01000,ko03009,ko03019 - - - RNase_E_G,S1 k59_547024_1 1395571.TMS3_0109225 4.09e-120 358.0 COG1167@1|root,COG1167@2|Bacteria,1MVGT@1224|Proteobacteria,1RPFK@1236|Gammaproteobacteria 1236|Gammaproteobacteria K Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs - - - ko:K00375,ko:K05825 ko00300,ko01100,ko01130,ko01210,map00300,map01100,map01130,map01210 - R01939 RC00006 ko00000,ko00001,ko01000,ko03000 - - - Aminotran_1_2,GntR k59_1736948_1 930945.SiRe_2320 1.56e-31 116.0 COG0599@1|root,arCOG02149@2157|Archaea,2XSKA@28889|Crenarchaeota 28889|Crenarchaeota S Carboxymuconolactone decarboxylase family - - 4.1.1.44 ko:K01607 ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220 - R03470 RC00938 ko00000,ko00001,ko01000 - - - CMD k59_662192_1 316067.Geob_0374 2.42e-35 125.0 COG2018@1|root,COG2018@2|Bacteria,1RDN5@1224|Proteobacteria,42S13@68525|delta/epsilon subdivisions,2WNKB@28221|Deltaproteobacteria,43T83@69541|Desulfuromonadales 28221|Deltaproteobacteria S PFAM Roadblock LC7 family protein mglB - - - - - - - - - - - Robl_LC7 k59_662192_2 1121918.ARWE01000001_gene253 7.53e-108 314.0 COG1100@1|root,COG1100@2|Bacteria,1R6NS@1224|Proteobacteria,42NIX@68525|delta/epsilon subdivisions,2WJ44@28221|Deltaproteobacteria,43RZJ@69541|Desulfuromonadales 28221|Deltaproteobacteria S ADP-ribosylation factor family mglA - - ko:K06883 - - - - ko00000 - - - Arf,Ras k59_435866_1 1385517.N800_10145 2.59e-24 107.0 COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,1S0D5@1236|Gammaproteobacteria,1X4Y2@135614|Xanthomonadales 135614|Xanthomonadales KLT Protein tyrosine kinase - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase,TPR_12 k59_1339121_1 1380394.JADL01000013_gene585 3.35e-118 355.0 COG3243@1|root,COG3243@2|Bacteria,1MU68@1224|Proteobacteria,2TR7S@28211|Alphaproteobacteria,2JQCH@204441|Rhodospirillales 204441|Rhodospirillales I Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus phbC - - ko:K03821 ko00650,map00650 - R04254 RC00004 ko00000,ko00001,ko01000 - - - Abhydrolase_1,PhaC_N k59_773847_2 118005.AWNK01000004_gene1068 3.69e-19 87.4 COG0613@1|root,COG0613@2|Bacteria 2|Bacteria Q PHP domain protein - - 3.1.3.97 ko:K07053 - - R00188,R11188 RC00078 ko00000,ko01000 - - - PHP k59_893150_1 1176165.CAJD01000013_gene752 5.01e-64 207.0 COG1351@1|root,COG1351@2|Bacteria,2HYJF@201174|Actinobacteria,4F8EJ@85019|Brevibacteriaceae 201174|Actinobacteria F Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant thyX - 2.1.1.148 ko:K03465 ko00240,ko00670,ko01100,map00240,map00670,map01100 - R06613 RC00022,RC00332 ko00000,ko00001,ko01000 - - - Thy1 k59_1282743_1 326423.RBAM_008680 9.53e-27 109.0 COG0596@1|root,COG0596@2|Bacteria,1UJGF@1239|Firmicutes,4IT98@91061|Bacilli,1ZJ8A@1386|Bacillus 91061|Bacilli S Alpha/beta hydrolase family - - - - - - - - - - - - Abhydrolase_1 k59_944142_1 1122225.AULQ01000002_gene658 3.29e-10 60.1 COG3087@1|root,COG3087@2|Bacteria,4NF9U@976|Bacteroidetes,1HYQM@117743|Flavobacteriia 976|Bacteroidetes D sporulation - - - - - - - - - - - - SPOR k59_944142_2 1123234.AUKI01000017_gene2593 1.76e-69 213.0 COG1607@1|root,COG1607@2|Bacteria,4NERA@976|Bacteroidetes,1HZ1Y@117743|Flavobacteriia 976|Bacteroidetes I thioesterase - - - - - - - - - - - - 4HBT k59_270007_1 1033991.RLEG12_03190 2.28e-41 157.0 COG3903@1|root,COG3903@2|Bacteria,1N5E5@1224|Proteobacteria,2UHJR@28211|Alphaproteobacteria,4BHBS@82115|Rhizobiaceae 28211|Alphaproteobacteria K Transcriptional regulator - - - - - - - - - - - - NAD_binding_8,Pyr_redox_2 k59_1624346_2 338963.Pcar_2240 6.92e-91 277.0 COG0133@1|root,COG0133@2|Bacteria,1MUS8@1224|Proteobacteria,42MIA@68525|delta/epsilon subdivisions,2WJJA@28221|Deltaproteobacteria 28221|Deltaproteobacteria E The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine trpB - 4.2.1.20 ko:K01696,ko:K06001 ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230 M00023 R00674,R02340,R02722 RC00209,RC00210,RC00700,RC00701,RC02868 ko00000,ko00001,ko00002,ko01000 - - - PALP k59_270010_2 246197.MXAN_2494 7.54e-29 113.0 COG3324@1|root,COG3324@2|Bacteria,1R81W@1224|Proteobacteria,439F3@68525|delta/epsilon subdivisions,2X4QF@28221|Deltaproteobacteria,2YZE7@29|Myxococcales 28221|Deltaproteobacteria S glyoxalase bleomycin resistance protein dioxygenase - - - ko:K06996 - - - - ko00000 - - - Glyoxalase k59_893161_1 697282.Mettu_0561 2.53e-34 132.0 28HK0@1|root,2Z7V0@2|Bacteria,1MXSJ@1224|Proteobacteria,1RRAP@1236|Gammaproteobacteria,1XG88@135618|Methylococcales 135618|Methylococcales S Domain of unknown function (DUF4105) - - - - - - - - - - - - DUF4105 k59_609820_1 1307436.PBF_17239 1.73e-83 257.0 COG2255@1|root,COG2255@2|Bacteria,1TR47@1239|Firmicutes,4HBMW@91061|Bacilli,1ZC5A@1386|Bacillus 91061|Bacilli L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing ruvB - 3.6.4.12 ko:K03551 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - RuvB_C,RuvB_N k59_155137_1 396588.Tgr7_3081 9.62e-12 64.7 COG0715@1|root,COG0715@2|Bacteria,1MVJA@1224|Proteobacteria,1RUI0@1236|Gammaproteobacteria,1WXI7@135613|Chromatiales 135613|Chromatiales P NMT1/THI5 like - - - ko:K02051 - M00188 - - ko00000,ko00002,ko02000 3.A.1.16,3.A.1.17 - - NMT1,NMT1_2 k59_832718_1 1219035.NT2_12_00780 2.16e-111 323.0 COG0625@1|root,COG0625@2|Bacteria,1MXM4@1224|Proteobacteria,2TTXD@28211|Alphaproteobacteria,2K1DG@204457|Sphingomonadales 204457|Sphingomonadales O Glutathione S-transferase - - 2.5.1.18 ko:K00799 ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418 - R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905 RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944 ko00000,ko00001,ko01000,ko02000 1.A.12.2.2,1.A.12.3.2 - - GST_C,GST_C_2,GST_N_3 k59_1228748_1 1229780.BN381_160007 6.93e-99 311.0 COG1034@1|root,COG1034@2|Bacteria,2GJGX@201174|Actinobacteria,3UWBF@52018|unclassified Actinobacteria (class) 201174|Actinobacteria C NADH-ubiquinone oxidoreductase-G iron-sulfur binding region nuoG GO:0003674,GO:0003824,GO:0003954,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0008152,GO:0009405,GO:0010941,GO:0016020,GO:0016491,GO:0016651,GO:0030312,GO:0033668,GO:0035821,GO:0042981,GO:0043067,GO:0043069,GO:0044003,GO:0044068,GO:0044403,GO:0044419,GO:0044464,GO:0044531,GO:0044532,GO:0048037,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051536,GO:0051540,GO:0051701,GO:0051704,GO:0051817,GO:0052040,GO:0052041,GO:0052150,GO:0052248,GO:0052433,GO:0052490,GO:0055114,GO:0060548,GO:0065007,GO:0071944 1.6.5.3 ko:K00336 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Fer2_4,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3 k59_270025_1 935567.JAES01000005_gene539 9.3e-31 122.0 COG3158@1|root,COG3158@2|Bacteria,1MUVH@1224|Proteobacteria,1RPM6@1236|Gammaproteobacteria,1X3P7@135614|Xanthomonadales 135614|Xanthomonadales P Transport of potassium into the cell kup GO:0003674,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015318,GO:0015672,GO:0016020,GO:0022857,GO:0022890,GO:0030001,GO:0034220,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0071804,GO:0071805,GO:0098655,GO:0098660,GO:0098662 - ko:K03549 - - - - ko00000,ko02000 2.A.72 - - K_trans k59_1580255_1 1000565.METUNv1_00806 5.43e-78 243.0 COG2603@1|root,COG2603@2|Bacteria,1N4T5@1224|Proteobacteria,2VIMH@28216|Betaproteobacteria,2KU8P@206389|Rhodocyclales 206389|Rhodocyclales H Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA ybbB - - ko:K06917 - - - - ko00000,ko01000,ko03016 - - - Rhodanese k59_444321_1 558173.CDOO_00220 1.87e-06 50.4 COG0768@1|root,COG0768@2|Bacteria,2GJUQ@201174|Actinobacteria,22KPA@1653|Corynebacteriaceae 201174|Actinobacteria M Cell division protein FtsI penicillin-binding protein 2 pbpA GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - ko:K05364 ko00550,map00550 - R04519 RC00005,RC00049 ko00000,ko00001,ko01011 - - - Transpeptidase k59_444321_2 465515.Mlut_00750 4.63e-78 257.0 COG0515@1|root,COG2815@1|root,COG0515@2|Bacteria,COG2815@2|Bacteria,2GJ1J@201174|Actinobacteria,1W8KD@1268|Micrococcaceae 201174|Actinobacteria KLT Serine threonine protein kinase pknB GO:0000270,GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005623,GO:0006022,GO:0006023,GO:0006024,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008047,GO:0008150,GO:0008152,GO:0008360,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009605,GO:0009607,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0010698,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019216,GO:0019217,GO:0019222,GO:0019538,GO:0022603,GO:0022604,GO:0030145,GO:0030203,GO:0030234,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032091,GO:0034645,GO:0036211,GO:0040007,GO:0042304,GO:0042546,GO:0042802,GO:0043085,GO:0043086,GO:0043167,GO:0043169,GO:0043170,GO:0043207,GO:0043388,GO:0043393,GO:0043412,GO:0044036,GO:0044038,GO:0044085,GO:0044092,GO:0044093,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044403,GO:0044419,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046777,GO:0046872,GO:0046890,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050793,GO:0050794,GO:0050896,GO:0051055,GO:0051098,GO:0051099,GO:0051100,GO:0051101,GO:0051128,GO:0051701,GO:0051704,GO:0051707,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0062012,GO:0062014,GO:0065007,GO:0065008,GO:0065009,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:0075136,GO:0080090,GO:0098772,GO:0140096,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 2.7.11.1 ko:K08884,ko:K12132 - - - - ko00000,ko01000,ko01001 - - - PASTA,Pkinase k59_1347753_1 1131266.ARWQ01000004_gene1463 2.8e-57 184.0 COG1339@1|root,arCOG01904@2157|Archaea,41SG9@651137|Thaumarchaeota 651137|Thaumarchaeota H Domain of unknown function DUF120 - - 2.7.1.161 ko:K07732 ko00740,ko01100,map00740,map01100 - R08574 RC00002,RC00017 ko00000,ko00001,ko01000 - - - CTP-dep_RFKase k59_1007974_1 870187.Thini_0745 4.41e-33 131.0 COG3264@1|root,COG3264@2|Bacteria,1MWSA@1224|Proteobacteria,1RMYY@1236|Gammaproteobacteria,462CG@72273|Thiotrichales 72273|Thiotrichales M Mechanosensitive ion channel - - - ko:K05802 - - - - ko00000,ko02000 1.A.23.1.1 - - MS_channel,MscS_TM k59_952558_1 391603.FBALC1_16217 7.55e-23 93.6 COG0261@1|root,COG3743@1|root,COG0261@2|Bacteria,COG3743@2|Bacteria,4NSHE@976|Bacteroidetes,1HYAI@117743|Flavobacteriia 976|Bacteroidetes J This protein binds to 23S rRNA in the presence of protein L20 rplU GO:0003674,GO:0003735,GO:0005198 - ko:K02888 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - HHH_5,Rho_N,Ribosomal_L21p k59_952558_2 1250232.JQNJ01000001_gene960 1.12e-52 166.0 COG0211@1|root,COG0211@2|Bacteria,4NS7T@976|Bacteroidetes,1I2S0@117743|Flavobacteriia 976|Bacteroidetes J Belongs to the bacterial ribosomal protein bL27 family rpmA GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - ko:K02899 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L27 k59_841472_1 887062.HGR_05414 2.44e-46 161.0 COG0789@1|root,COG0789@2|Bacteria,1R2NF@1224|Proteobacteria,2VJDG@28216|Betaproteobacteria,4ACBQ@80864|Comamonadaceae 28216|Betaproteobacteria K PFAM regulatory protein, MerR - - - ko:K22491 - - - - ko00000,ko03000 - - - B12-binding,B12-binding_2,MerR_1 k59_731726_1 765912.Thimo_3399 3.74e-37 131.0 28JRZ@1|root,2Z9HI@2|Bacteria,1R52Z@1224|Proteobacteria,1RRWN@1236|Gammaproteobacteria,1WYE4@135613|Chromatiales 135613|Chromatiales S Domain of unknown function (DUF4126) - - - - - - - - - - - - DUF4126 k59_1181046_1 1054213.HMPREF9946_00696 1.91e-14 81.3 COG4773@1|root,COG4773@2|Bacteria,1QTT0@1224|Proteobacteria,2U1HB@28211|Alphaproteobacteria 28211|Alphaproteobacteria P TonB dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_901702_1 1223521.BBJX01000005_gene2080 1.45e-44 154.0 COG0581@1|root,COG0581@2|Bacteria,1MUWB@1224|Proteobacteria,2VH6Y@28216|Betaproteobacteria,4ABXP@80864|Comamonadaceae 28216|Betaproteobacteria P TIGRFAM phosphate ABC transporter, inner membrane subunit PstA pstA - - ko:K02038 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - BPD_transp_1 k59_901702_2 1485544.JQKP01000004_gene502 4.58e-71 223.0 COG0573@1|root,COG0573@2|Bacteria,1MVKP@1224|Proteobacteria,2VH4G@28216|Betaproteobacteria,44VHI@713636|Nitrosomonadales 28216|Betaproteobacteria P probably responsible for the translocation of the substrate across the membrane pstC - - ko:K02037 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - BPD_transp_1 k59_1347778_1 566466.NOR53_144 9.14e-118 345.0 COG0379@1|root,COG0379@2|Bacteria,1MWQU@1224|Proteobacteria,1RMFS@1236|Gammaproteobacteria,1J56G@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate nadA GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006734,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008987,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016053,GO:0017144,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0019805,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046496,GO:0046874,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.5.1.72 ko:K03517 ko00760,ko01100,map00760,map01100 M00115 R04292 RC01119 ko00000,ko00001,ko00002,ko01000 - - iAF1260.b0750,iAPECO1_1312.APECO1_1338,iB21_1397.B21_00692,iBWG_1329.BWG_0602,iECBD_1354.ECBD_2917,iECB_1328.ECB_00703,iECDH10B_1368.ECDH10B_0817,iECDH1ME8569_1439.ECDH1ME8569_0703,iECD_1391.ECD_00703,iECED1_1282.ECED1_0711,iECOK1_1307.ECOK1_0750,iECP_1309.ECP_0761,iECS88_1305.ECS88_0766,iECSP_1301.ECSP_0802,iECs_1301.ECs0778,iETEC_1333.ETEC_0754,iEcDH1_1363.EcDH1_2892,iEcolC_1368.EcolC_2912,iJN746.PP_1231,iJO1366.b0750,iJR904.b0750,iUMN146_1321.UM146_13905,iUTI89_1310.UTI89_C0747,iY75_1357.Y75_RS03905,iZ_1308.Z0919 NadA k59_278752_1 1356854.N007_07605 9.4e-35 126.0 COG3880@1|root,COG3880@2|Bacteria,1V6YM@1239|Firmicutes,4HH4R@91061|Bacilli,278EU@186823|Alicyclobacillaceae 91061|Bacilli S UvrB/uvrC motif mcsA GO:0003674,GO:0005488,GO:0005507,GO:0006950,GO:0008150,GO:0008270,GO:0010035,GO:0010038,GO:0042221,GO:0043167,GO:0043169,GO:0046686,GO:0046688,GO:0046870,GO:0046872,GO:0046914,GO:0050896,GO:0050897,GO:0097501,GO:1990169,GO:1990170 - ko:K19411 - - - - ko00000 - - - UVR k59_1181076_1 1122137.AQXF01000002_gene461 3.28e-110 327.0 COG1446@1|root,COG1446@2|Bacteria,1MWFC@1224|Proteobacteria,2TU8K@28211|Alphaproteobacteria 28211|Alphaproteobacteria E asparaginase iaaA - 3.4.19.5,3.5.1.1 ko:K01424,ko:K13051 ko00250,ko00460,ko01100,ko01110,map00250,map00460,map01100,map01110 - R00485 RC00010,RC02798 ko00000,ko00001,ko01000,ko01002 - - - Asparaginase_2,Peptidase_S51 k59_1410420_1 1415778.JQMM01000001_gene2051 1.79e-167 486.0 COG1138@1|root,COG1138@2|Bacteria,1MUQS@1224|Proteobacteria,1RMY5@1236|Gammaproteobacteria,1J4J1@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O Cytochrome c-type biogenesis protein ccmF GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016021,GO:0016043,GO:0017003,GO:0017004,GO:0017006,GO:0018063,GO:0019538,GO:0020037,GO:0022607,GO:0031224,GO:0031226,GO:0034622,GO:0036211,GO:0043170,GO:0043412,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0046906,GO:0048037,GO:0065003,GO:0071704,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564 - ko:K02198 - - - - ko00000,ko02000 9.B.14.1 - - CcmF_C,Cytochrom_C_asm k59_1688243_1 2110.MAGa0540 1.44e-07 55.5 COG0030@1|root,COG0030@2|Bacteria,3WTCB@544448|Tenericutes 544448|Tenericutes J Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits ksgA - 2.1.1.182 ko:K02528 - - R10716 RC00003,RC03257 ko00000,ko01000,ko03009 - - - RrnaAD k59_1688243_2 1157490.EL26_11895 5.39e-11 63.2 COG0084@1|root,COG0084@2|Bacteria,1TNY1@1239|Firmicutes,4HA74@91061|Bacilli,27859@186823|Alicyclobacillaceae 91061|Bacilli L TatD related DNase tatD GO:0003674,GO:0003824,GO:0004518,GO:0004536,GO:0006139,GO:0006259,GO:0006308,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016787,GO:0016788,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901361,GO:1901575 - ko:K03424 - - - - ko00000,ko01000 - - - TatD_DNase k59_1797642_1 688270.Celal_1413 2.52e-29 116.0 COG0491@1|root,COG0491@2|Bacteria,4NE98@976|Bacteroidetes,1HX48@117743|Flavobacteriia,1F7TJ@104264|Cellulophaga 976|Bacteroidetes S Metallo-beta-lactamase superfamily - - - - - - - - - - - - Lactamase_B k59_1236813_2 1323663.AROI01000060_gene1411 1.7e-31 124.0 COG0397@1|root,COG0397@2|Bacteria,1MVK3@1224|Proteobacteria,1RNCS@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Belongs to the UPF0061 (SELO) family ydiU - - - - - - - - - - - UPF0061 k59_336413_1 391603.FBALC1_05973 1.06e-60 194.0 COG0224@1|root,COG0224@2|Bacteria,4NM5H@976|Bacteroidetes,1I2IW@117743|Flavobacteriia 976|Bacteroidetes C WbqC-like protein - - - - - - - - - - - - WbqC k59_1688253_1 1266914.ATUK01000012_gene284 4.31e-35 124.0 COG1595@1|root,COG1595@2|Bacteria,1MX7T@1224|Proteobacteria,1RN64@1236|Gammaproteobacteria,1WXBZ@135613|Chromatiales 135613|Chromatiales K Belongs to the sigma-70 factor family. ECF subfamily - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 k59_336414_2 1122137.AQXF01000004_gene1612 9.49e-06 46.2 COG0476@1|root,COG0476@2|Bacteria,1MW7H@1224|Proteobacteria,2TRWY@28211|Alphaproteobacteria 28211|Alphaproteobacteria H Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family moeB - 2.7.7.80 ko:K21029 ko04122,map04122 - R07459 RC00043 ko00000,ko00001,ko01000 - - - ThiF k59_954227_1 1168065.DOK_17195 1.53e-56 187.0 COG0452@1|root,COG0452@2|Bacteria,1MVQP@1224|Proteobacteria,1RMKQ@1236|Gammaproteobacteria,1J4KE@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine coaBC GO:0000166,GO:0003674,GO:0003824,GO:0004632,GO:0004633,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0010181,GO:0015936,GO:0015937,GO:0016829,GO:0016830,GO:0016831,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0032553,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0036094,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 4.1.1.36,6.3.2.5 ko:K13038 ko00770,ko01100,map00770,map01100 M00120 R03269,R04231 RC00064,RC00090,RC00822 ko00000,ko00001,ko00002,ko01000 - - iEC042_1314.EC042_3945,iECUMN_1333.ECUMN_4154,iJN746.PP_5285,iSBO_1134.SBO_3641 DFP,Flavoprotein k59_843243_1 1192759.AKIB01000026_gene2145 3.32e-61 195.0 COG0625@1|root,COG0625@2|Bacteria,1Q5XX@1224|Proteobacteria,2U18C@28211|Alphaproteobacteria,2K8H4@204457|Sphingomonadales 204457|Sphingomonadales O Glutathione S-transferase, N-terminal domain - - 2.5.1.18 ko:K00799 ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418 - R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905 RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944 ko00000,ko00001,ko01000,ko02000 1.A.12.2.2,1.A.12.3.2 - - GST_N_3 k59_843243_2 1112212.JH584235_gene3600 2.58e-13 68.9 COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2TQR1@28211|Alphaproteobacteria,2JZVD@204457|Sphingomonadales 204457|Sphingomonadales C belongs to the aldehyde dehydrogenase family - - 1.2.1.3 ko:K00128 ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130 M00135 R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146 RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_501136_1 439235.Dalk_1072 2.67e-91 300.0 COG0784@1|root,COG2203@1|root,COG2204@1|root,COG4191@1|root,COG0784@2|Bacteria,COG2203@2|Bacteria,COG2204@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42MC4@68525|delta/epsilon subdivisions,2WIZU@28221|Deltaproteobacteria,2MJ2F@213118|Desulfobacterales 28221|Deltaproteobacteria T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - ABC_sub_bind,GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg k59_280437_1 1216007.AOPM01000073_gene1348 3.38e-23 105.0 COG0747@1|root,COG3637@1|root,COG4625@1|root,COG0747@2|Bacteria,COG3637@2|Bacteria,COG4625@2|Bacteria,1QU2X@1224|Proteobacteria,1T3XP@1236|Gammaproteobacteria 1236|Gammaproteobacteria M outer membrane autotransporter barrel domain - - - - - - - - - - - - DUF4347 k59_1123929_1 71139.XP_010060996.1 0.000299 42.7 COG2802@1|root,KOG4159@2759|Eukaryota,37KXB@33090|Viridiplantae,3GGBR@35493|Streptophyta 35493|Streptophyta O LON peptidase N-terminal domain and RING finger protein - - - - - - - - - - - - LON_substr_bdg k59_1123932_1 1049564.TevJSym_an00380 9e-105 318.0 COG0469@1|root,COG0469@2|Bacteria,1MU21@1224|Proteobacteria,1RMW3@1236|Gammaproteobacteria,1J4EJ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria G Belongs to the pyruvate kinase family pykA GO:0003674,GO:0003824,GO:0004743,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016043,GO:0016052,GO:0016053,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0022607,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042802,GO:0042866,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055086,GO:0065003,GO:0071704,GO:0071840,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576 2.7.1.40 ko:K00873 ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230 M00001,M00002,M00049,M00050 R00200,R00430,R01138,R01858,R02320 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - e_coli_core.b1854,iAF1260.b1854,iB21_1397.B21_01813,iBWG_1329.BWG_1668,iEC042_1314.EC042_2021,iECBD_1354.ECBD_1784,iECB_1328.ECB_01825,iECDH10B_1368.ECDH10B_1995,iECDH1ME8569_1439.ECDH1ME8569_1801,iECD_1391.ECD_01825,iECO103_1326.ECO103_2044,iECO111_1330.ECO111_2362,iECO26_1355.ECO26_2692,iECUMN_1333.ECUMN_2152,iETEC_1333.ETEC_1887,iEcDH1_1363.EcDH1_1786,iEcE24377_1341.EcE24377A_2084,iEcHS_1320.EcHS_A1947,iEcSMS35_1347.EcSMS35_1332,iEcolC_1368.EcolC_1778,iG2583_1286.G2583_2306,iJO1366.b1854,iJR904.b1854,iSBO_1134.SBO_1162,iSSON_1240.SSON_1294,iSbBS512_1146.SbBS512_E2130,iUMNK88_1353.UMNK88_2326,iY75_1357.Y75_RS09740 PK,PK_C k59_338084_1 93220.LV28_16050 2.06e-235 654.0 COG0137@1|root,COG0137@2|Bacteria,1MV0Y@1224|Proteobacteria,2VJ7Z@28216|Betaproteobacteria,1K0VF@119060|Burkholderiaceae 28216|Betaproteobacteria E Belongs to the argininosuccinate synthase family. Type argG GO:0000050,GO:0000053,GO:0003674,GO:0003824,GO:0004055,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006575,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0019627,GO:0019752,GO:0034641,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:0072350,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 6.3.4.5 ko:K01940 ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418 M00029,M00844,M00845 R01954 RC00380,RC00629 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Arginosuc_synth k59_1581906_1 903818.KI912269_gene537 5.91e-44 159.0 COG1164@1|root,COG1164@2|Bacteria 2|Bacteria E metalloendopeptidase activity pepF GO:0003674,GO:0003824,GO:0004175,GO:0004222,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006465,GO:0006508,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009987,GO:0010467,GO:0016485,GO:0016787,GO:0019538,GO:0034641,GO:0043170,GO:0043603,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0051604,GO:0070011,GO:0071704,GO:0140096,GO:1901564 - ko:K08602 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M3,Peptidase_M3_N k59_1581906_2 523791.Kkor_0358 7.44e-39 150.0 COG2203@1|root,COG5001@1|root,COG2203@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1XHGD@135619|Oceanospirillales 135619|Oceanospirillales T signal transduction protein containing a membrane domain, an EAL and a GGDEF domain - - - - - - - - - - - - EAL,GAF_2,GGDEF,PAS_9,Response_reg k59_1349224_1 1187851.A33M_1652 9.21e-84 258.0 COG3039@1|root,COG3039@2|Bacteria,1MUVI@1224|Proteobacteria,2TSA7@28211|Alphaproteobacteria,3FDDV@34008|Rhodovulum 28211|Alphaproteobacteria L Transposase DDE domain - - - - - - - - - - - - DDE_Tnp_1,DDE_Tnp_1_6,DUF772 k59_110834_1 264462.Bd3790 9.53e-18 85.5 COG0484@1|root,COG1426@1|root,COG0484@2|Bacteria,COG1426@2|Bacteria,1NCYU@1224|Proteobacteria,42WS1@68525|delta/epsilon subdivisions,2MT9U@213481|Bdellovibrionales,2WSDX@28221|Deltaproteobacteria 213481|Bdellovibrionales O Helix-turn-helix domain - - - - - - - - - - - - DnaJ,HTH_25 k59_110834_3 555088.DealDRAFT_2710 5.7e-55 183.0 COG0564@1|root,COG0564@2|Bacteria,1TPCM@1239|Firmicutes,247Y2@186801|Clostridia,42JJW@68298|Syntrophomonadaceae 186801|Clostridia J Responsible for synthesis of pseudouridine from uracil rluD - 5.4.99.23 ko:K06180 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2,S4 k59_620456_1 382464.ABSI01000005_gene1043 8.69e-18 87.0 COG1657@1|root,COG1657@2|Bacteria,46V6M@74201|Verrucomicrobia,2IUBE@203494|Verrucomicrobiae 203494|Verrucomicrobiae I Pectic acid lyase - - - - - - - - - - - - Pec_lyase k59_1746888_1 1410626.JHXB01000003_gene954 9.19e-39 139.0 COG0336@1|root,COG0336@2|Bacteria,1TPBV@1239|Firmicutes,247JF@186801|Clostridia,27IBD@186928|unclassified Lachnospiraceae 186801|Clostridia J Belongs to the RNA methyltransferase TrmD family trmD - 2.1.1.228 ko:K00554 - - R00597 RC00003,RC00334 ko00000,ko01000,ko03016 - - - tRNA_m1G_MT k59_1746888_2 491915.Aflv_1759 5.26e-14 67.8 COG0335@1|root,COG0335@2|Bacteria,1V6FT@1239|Firmicutes,4HIK3@91061|Bacilli,21VQP@150247|Anoxybacillus 91061|Bacilli J This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site rplS GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - ko:K02884 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L19 k59_1123940_1 1144275.COCOR_03289 4.83e-18 84.0 COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria 1224|Proteobacteria IQ COG0318, Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II - - - - - - - - - - - - AMP-binding,AMP-binding_C,Acyl_transf_1,Bac_luciferase,Condensation,KAsynt_C_assoc,Ketoacyl-synt_C,PP-binding,Thioesterase,ketoacyl-synt k59_1463083_1 121759.XP_010759132.1 1.81e-79 253.0 COG0362@1|root,KOG2653@2759|Eukaryota,38BP7@33154|Opisthokonta,3NVGP@4751|Fungi,3QNUN@4890|Ascomycota,20ACR@147545|Eurotiomycetes,3B1T3@33183|Onygenales,3FIVR@34383|Onygenales incertae sedis 4751|Fungi G Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH GND1 GO:0000166,GO:0003674,GO:0003824,GO:0004616,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005829,GO:0005886,GO:0005975,GO:0006081,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006098,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009051,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016052,GO:0016053,GO:0016054,GO:0016310,GO:0016491,GO:0016614,GO:0016616,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019520,GO:0019521,GO:0019637,GO:0019682,GO:0019693,GO:0019752,GO:0032787,GO:0033554,GO:0034404,GO:0034599,GO:0034641,GO:0034654,GO:0034655,GO:0036094,GO:0042221,GO:0042866,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044262,GO:0044270,GO:0044271,GO:0044275,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046176,GO:0046177,GO:0046390,GO:0046394,GO:0046395,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0048037,GO:0050661,GO:0050662,GO:0050896,GO:0051156,GO:0051186,GO:0051188,GO:0051716,GO:0055086,GO:0055114,GO:0061688,GO:0070887,GO:0071704,GO:0071944,GO:0072329,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:1901135,GO:1901137,GO:1901265,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901575,GO:1901576 1.1.1.343,1.1.1.44 ko:K00033 ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00480,map01100,map01110,map01120,map01130,map01200 M00004,M00006 R01528,R10221 RC00001,RC00539 ko00000,ko00001,ko00002,ko01000 - - iMM904.YHR183W,iND750.YHR183W 6PGD,NAD_binding_2 k59_1412127_1 700598.Niako_3744 2.04e-69 219.0 COG1262@1|root,COG1262@2|Bacteria,4NFR2@976|Bacteroidetes,1IPME@117747|Sphingobacteriia 976|Bacteroidetes S PFAM Formylglycine-generating sulfatase enzyme - - - - - - - - - - - - FGE-sulfatase k59_280455_1 555793.WSK_0251 8.39e-20 89.4 COG0542@1|root,COG0542@2|Bacteria,1MV8B@1224|Proteobacteria,2TQUZ@28211|Alphaproteobacteria,2K0MN@204457|Sphingomonadales 204457|Sphingomonadales O Belongs to the ClpA ClpB family clpA - - ko:K03694 - - - - ko00000,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N k59_280455_2 1219035.NT2_04_03700 2.43e-34 121.0 COG2346@1|root,COG2346@2|Bacteria,1NBIW@1224|Proteobacteria,2U65Z@28211|Alphaproteobacteria,2K6G2@204457|Sphingomonadales 204457|Sphingomonadales S Bacterial-like globin - - - ko:K06886 - - - - ko00000 - - - Bac_globin k59_1238475_1 1123261.AXDW01000002_gene1648 4.29e-86 266.0 COG0372@1|root,COG0372@2|Bacteria,1MUKX@1224|Proteobacteria,1RNDK@1236|Gammaproteobacteria,1X3KV@135614|Xanthomonadales 135614|Xanthomonadales C Belongs to the citrate synthase family gltA - 2.3.3.1 ko:K01647 ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00740 R00351 RC00004,RC00067 br01601,ko00000,ko00001,ko00002,ko01000 - - - Citrate_synt k59_280457_2 679201.HMPREF9334_01848 1.62e-06 54.3 COG1213@1|root,COG1213@2|Bacteria,1V3I9@1239|Firmicutes,4H6RP@909932|Negativicutes 909932|Negativicutes M Nucleotidyl transferase - - - - - - - - - - - - NTP_transf_3 k59_1581924_1 1337093.MBE-LCI_3777 2.14e-145 419.0 COG3328@1|root,COG3328@2|Bacteria,1MU4P@1224|Proteobacteria,2TUQT@28211|Alphaproteobacteria,2P9DW@245186|Loktanella 28211|Alphaproteobacteria L MULE transposase domain - - - - - - - - - - - - Transposase_mut k59_1412132_1 566466.NOR53_3467 2.28e-89 280.0 COG1020@1|root,COG1020@2|Bacteria,1N7HY@1224|Proteobacteria,1SMER@1236|Gammaproteobacteria,1J8V8@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Protein of unknown function (DUF1298) - - - - - - - - - - - - DUF1298,WES_acyltransf k59_783632_1 316407.1799942 4.06e-12 64.7 COG1073@1|root,COG1073@2|Bacteria,1RFAF@1224|Proteobacteria,1S2YT@1236|Gammaproteobacteria,3XPC6@561|Escherichia 1236|Gammaproteobacteria S Prolyl oligopeptidase family yfhR - - ko:K06889 - - - - ko00000 - - - Hydrolase_4 k59_783632_2 316407.1799941 1.63e-67 210.0 COG0483@1|root,COG0483@2|Bacteria,1MUQT@1224|Proteobacteria,1RNME@1236|Gammaproteobacteria,3XNR1@561|Escherichia 1236|Gammaproteobacteria G inositol metabolic process suhB GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006020,GO:0006066,GO:0006793,GO:0006796,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0008934,GO:0009056,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019637,GO:0019751,GO:0023052,GO:0031403,GO:0031420,GO:0042578,GO:0043167,GO:0043169,GO:0043647,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046164,GO:0046174,GO:0046434,GO:0046838,GO:0046855,GO:0046872,GO:0047954,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0052745,GO:0052834,GO:0065007,GO:0071545,GO:0071704,GO:1901575,GO:1901615,GO:1901616 3.1.3.25 ko:K01092 ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070 M00131 R01185,R01186,R01187 RC00078 ko00000,ko00001,ko00002,ko01000 - - iECP_1309.ECP_2538,iPC815.YPO2899 Inositol_P k59_557097_1 365528.KB891275_gene701 1.82e-08 55.5 COG2124@1|root,COG2124@2|Bacteria,2HCZN@201174|Actinobacteria 201174|Actinobacteria Q cytochrome P450 - - 1.14.13.141 ko:K15981 ko00984,ko01120,map00984,map01120 - R09859,R11357 RC01216,RC03368 ko00000,ko00001,ko00199,ko01000 - - - p450 k59_672261_1 298653.Franean1_1217 6.72e-79 265.0 COG1201@1|root,COG1201@2|Bacteria,2GJG3@201174|Actinobacteria,4ES42@85013|Frankiales 201174|Actinobacteria L DEAD DEAH box helicase domain protein lhr - - ko:K03724 - - - - ko00000,ko01000,ko03400 - - - DEAD,DEAD_assoc,HTH_42,Helicase_C k59_557102_1 316407.4902969 6.7e-25 95.9 COG0454@1|root,COG0454@2|Bacteria,1QUD7@1224|Proteobacteria,1T1U8@1236|Gammaproteobacteria,3XQ3D@561|Escherichia 1236|Gammaproteobacteria K SOS response yafP - - ko:K03830 - - - - ko00000,ko01000 - - - Acetyltransf_10 k59_557102_2 316407.4902968 1.69e-75 226.0 28S4M@1|root,2ZEGB@2|Bacteria,1RAMY@1224|Proteobacteria,1S2NG@1236|Gammaproteobacteria 1236|Gammaproteobacteria S this blockage is overcome by subsequent expression of antitoxin YafN. Overexpression causes cleavage of a number of mRNAs in a ribosome-dependent fashion. YafO binding to the 50S ribosomal subunit in the translation complex induces mRNA cleavage 3' to the region protected by the ribosome yafO GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0005488,GO:0006139,GO:0006417,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0016070,GO:0016787,GO:0016788,GO:0017148,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0034248,GO:0034249,GO:0034641,GO:0043021,GO:0043023,GO:0043170,GO:0044237,GO:0044238,GO:0044877,GO:0046483,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:2000112,GO:2000113 - ko:K19160 - - - - ko00000,ko01000,ko02048 - - - YafO_toxin k59_54916_1 631362.Thi970DRAFT_01420 1.59e-43 153.0 COG0834@1|root,COG0834@2|Bacteria,1MV5D@1224|Proteobacteria,1RPBX@1236|Gammaproteobacteria 1236|Gammaproteobacteria ET ABC-type amino acid transport signal transduction systems periplasmic component domain gltI GO:0003333,GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0006810,GO:0006811,GO:0006820,GO:0006835,GO:0006836,GO:0006855,GO:0006865,GO:0008150,GO:0015711,GO:0015740,GO:0015800,GO:0015807,GO:0015813,GO:0015849,GO:0015893,GO:0016595,GO:0016597,GO:0030288,GO:0030313,GO:0031406,GO:0031975,GO:0034220,GO:0036094,GO:0042221,GO:0042493,GO:0042597,GO:0043167,GO:0043168,GO:0043177,GO:0044464,GO:0046942,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0070335,GO:0070778,GO:0071702,GO:0071705,GO:0098656,GO:1902475,GO:1903825,GO:1905039 - ko:K10001 ko02010,ko02020,map02010,map02020 M00230 - - ko00000,ko00001,ko00002,ko02000 3.A.1.3.19,3.A.1.3.4 - iECH74115_1262.ECH74115_0748,iECSE_1348.ECSE_0725,iECSP_1301.ECSP_0707,iECW_1372.ECW_m0710,iECs_1301.ECs0694,iEKO11_1354.EKO11_3211,iG2583_1286.G2583_0819,iSFV_1184.SFV_0671,iSF_1195.SF0626,iS_1188.S0648,iWFL_1372.ECW_m0710,iZ_1308.Z0805 SBP_bac_3 k59_1009610_1 1121946.AUAX01000001_gene2329 2.18e-55 199.0 COG3629@1|root,COG3903@1|root,COG3629@2|Bacteria,COG3903@2|Bacteria,2GIZ1@201174|Actinobacteria,4D96C@85008|Micromonosporales 201174|Actinobacteria K Transcriptional regulator - - - - - - - - - - - - AAA_16,AAA_22,ANAPC5,BTAD,NB-ARC,Trans_reg_C k59_954270_1 1198232.CYCME_1941 4.7e-30 118.0 COG2907@1|root,COG2907@2|Bacteria,1MV4Z@1224|Proteobacteria,1RP4P@1236|Gammaproteobacteria,45ZNJ@72273|Thiotrichales 72273|Thiotrichales S Flavin containing amine oxidoreductase - - - ko:K06954 - - - - ko00000 - - - Amino_oxidase,NAD_binding_8 k59_954270_2 754477.Q7C_336 4.79e-37 137.0 COG3496@1|root,COG3496@2|Bacteria,1RC56@1224|Proteobacteria,1RRT8@1236|Gammaproteobacteria,460Q0@72273|Thiotrichales 72273|Thiotrichales S Protein of unknown function (DUF1365) - - - ko:K09701 - - - - ko00000 - - - DUF1365 k59_620479_1 1237149.C900_00078 1.61e-14 74.3 COG3571@1|root,COG3571@2|Bacteria,4NEGG@976|Bacteroidetes,47UR6@768503|Cytophagia 976|Bacteroidetes S Dienelactone hydrolase family - - - ko:K07020 - - - - ko00000 - - - Abhydrolase_5 k59_620479_3 1395587.P364_0119585 5.79e-05 45.8 COG0491@1|root,COG0491@2|Bacteria,1TSWY@1239|Firmicutes,4HE91@91061|Bacilli,26WWW@186822|Paenibacillaceae 91061|Bacilli S Metallo-beta-lactamase superfamily gloB - 3.1.2.6 ko:K01069 ko00620,map00620 - R01736 RC00004,RC00137 ko00000,ko00001,ko01000 - - - HAGH_C,Lactamase_B k59_1293341_1 1128421.JAGA01000003_gene3365 4.27e-68 216.0 COG0179@1|root,COG0179@2|Bacteria,2NP4G@2323|unclassified Bacteria 2|Bacteria Q Fumarylacetoacetate (FAA) hydrolase family - - - - - - - - - - - - DUF2437,FAA_hydrolase k59_620481_1 1122137.AQXF01000002_gene460 2.12e-79 253.0 COG4805@1|root,COG4805@2|Bacteria,1MUBX@1224|Proteobacteria,2TSQN@28211|Alphaproteobacteria 28211|Alphaproteobacteria C Protein conserved in bacteria - - - - - - - - - - - - DUF885 k59_110896_1 1123251.ATWM01000006_gene2201 1.43e-78 266.0 COG0086@1|root,COG0086@2|Bacteria,2GKWF@201174|Actinobacteria,4FFYE@85021|Intrasporangiaceae 201174|Actinobacteria K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoC GO:0000428,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0030880,GO:0032991,GO:0040007,GO:0044424,GO:0044464,GO:0061695,GO:0071944,GO:1902494,GO:1990234 2.7.7.6 ko:K03046 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5 k59_165201_1 1123237.Salmuc_00558 3.52e-167 484.0 COG0056@1|root,COG0056@2|Bacteria,1MVHM@1224|Proteobacteria,2TQZ8@28211|Alphaproteobacteria 28211|Alphaproteobacteria C Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit atpA_2 - 3.6.3.14 ko:K02111 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - - ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N k59_446124_1 627192.SLG_37520 1.54e-106 314.0 COG3384@1|root,COG3384@2|Bacteria,1MW77@1224|Proteobacteria,2TRP1@28211|Alphaproteobacteria,2K8TJ@204457|Sphingomonadales 204457|Sphingomonadales C Catalytic LigB subunit of aromatic ring-opening dioxygenase - - 1.13.11.8 ko:K04101 ko00362,ko00624,ko00627,ko01120,map00362,map00624,map00627,map01120 - R01632,R03550,R04280,R09565 RC00233,RC00387,RC00535,RC02567,RC02694 br01602,ko00000,ko00001,ko01000 - - - LigB k59_446124_2 400668.Mmwyl1_3921 4.99e-42 140.0 COG3384@1|root,COG3384@2|Bacteria,1RIBC@1224|Proteobacteria,1SYBG@1236|Gammaproteobacteria,1XPM7@135619|Oceanospirillales 135619|Oceanospirillales S PFAM Extradiol ring-cleavage dioxygenase LigAB LigA subunit - - 1.13.11.8 ko:K04100 ko00362,ko00624,ko00627,ko01120,map00362,map00624,map00627,map01120 - R01632,R03550,R04280,R09565 RC00233,RC00387,RC00535,RC02567,RC02694 br01602,ko00000,ko00001,ko01000 - - - LigA k59_395198_1 1449346.JQMO01000002_gene646 9.8e-25 98.2 COG2018@1|root,COG2018@2|Bacteria,2IMEY@201174|Actinobacteria 201174|Actinobacteria S Roadblock/LC7 domain - - - - - - - - - - - - - k59_1009653_1 1382306.JNIM01000001_gene3742 9.08e-10 59.7 COG0781@1|root,COG0781@2|Bacteria,2G6XA@200795|Chloroflexi 200795|Chloroflexi K Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons nusB - - ko:K03625 - - - - ko00000,ko03009,ko03021 - - - NusB k59_501223_1 316407.1651366 5.8e-14 67.8 COG0783@1|root,COG0783@2|Bacteria,1RAC5@1224|Proteobacteria,1RR4N@1236|Gammaproteobacteria,3XN85@561|Escherichia 1236|Gammaproteobacteria P During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction dps GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005506,GO:0005515,GO:0005575,GO:0005623,GO:0006950,GO:0008150,GO:0008199,GO:0009289,GO:0009295,GO:0009605,GO:0009991,GO:0031667,GO:0042594,GO:0042802,GO:0042995,GO:0043167,GO:0043169,GO:0044464,GO:0046872,GO:0046914,GO:0050896,GO:0097159,GO:1901363 - ko:K04047 - - - - ko00000,ko03036 - - - Ferritin k59_501223_2 1440052.EAKF1_ch0662 1.79e-72 223.0 COG0834@1|root,COG0834@2|Bacteria,1MV3Q@1224|Proteobacteria,1RRI5@1236|Gammaproteobacteria,3XMFU@561|Escherichia 1236|Gammaproteobacteria ET glutamine-binding periplasmic protein glnH GO:0005575,GO:0005623,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0044464 - ko:K02030,ko:K10036 ko02010,map02010 M00227,M00236 - - ko00000,ko00001,ko00002,ko02000 3.A.1.3,3.A.1.3.2 - - SBP_bac_3 k59_338153_1 436308.Nmar_0088 3.13e-179 526.0 COG1201@1|root,arCOG00557@2157|Archaea,41S8P@651137|Thaumarchaeota 651137|Thaumarchaeota L DEAD/H associated - - - ko:K03724 - - - - ko00000,ko01000,ko03400 - - - DEAD,DEAD_assoc,Helicase_C k59_1524460_1 85643.Tmz1t_3202 8.53e-22 96.3 COG2206@1|root,COG2206@2|Bacteria,1R3VR@1224|Proteobacteria,2VMY5@28216|Betaproteobacteria,2KVPZ@206389|Rhodocyclales 206389|Rhodocyclales T Domain of unknown function (DUF3391) - - - - - - - - - - - - DUF3391,HD_5 k59_1192299_3 1282876.BAOK01000002_gene802 1.06e-37 138.0 COG1364@1|root,COG1364@2|Bacteria,1MU0T@1224|Proteobacteria,2TS98@28211|Alphaproteobacteria,4BPI6@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria E Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate argJ GO:0003674,GO:0003824,GO:0004042,GO:0004358,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006592,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.3.1.1,2.3.1.35 ko:K00620 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028 R00259,R02282 RC00004,RC00064 ko00000,ko00001,ko00002,ko01000 - - - ArgJ k59_909600_2 240302.BN982_01195 2.1e-37 140.0 COG0463@1|root,COG0463@2|Bacteria,1TPR3@1239|Firmicutes,4HC2Z@91061|Bacilli,3NFYG@45667|Halobacillus 91061|Bacilli M Glycosyltransferase like family 2 - - - ko:K20534 - - - - ko00000,ko01000,ko01005,ko02000 4.D.2.1.9 GT2 - Glycos_transf_2 k59_1757027_1 1229909.NSED_02125 6.33e-18 81.3 COG0517@1|root,arCOG00601@2157|Archaea 2157|Archaea C CBS domain - - - - - - - - - - - - - k59_1757027_2 436308.Nmar_1098 4.81e-203 569.0 COG0608@1|root,arCOG00424@2157|Archaea,41SE2@651137|Thaumarchaeota 651137|Thaumarchaeota L DHHA1 domain - - - ko:K07463 - - - - ko00000 - - - DHHA1 k59_1644333_1 631362.Thi970DRAFT_01929 1.55e-86 271.0 COG0373@1|root,COG0373@2|Bacteria,1MU41@1224|Proteobacteria,1RNQ8@1236|Gammaproteobacteria,1WX0A@135613|Chromatiales 135613|Chromatiales H Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) hemA - 1.2.1.70 ko:K02492 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R04109 RC00055,RC00149 ko00000,ko00001,ko00002,ko01000 - - - GlutR_N,GlutR_dimer,Shikimate_DH k59_1417933_1 1216966.BAUC01000010_gene2293 1.04e-33 124.0 COG0742@1|root,COG0742@2|Bacteria,1MXKW@1224|Proteobacteria,1RN21@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Specifically methylates the guanine in position 966 of 16S rRNA in the assembled 30S particle rsmD GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0008990,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0052913,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.171 ko:K08316 - - R07234 RC00003 ko00000,ko01000,ko03009 - - - Cons_hypoth95 k59_1587395_1 1254432.SCE1572_10350 3.47e-30 122.0 COG0265@1|root,COG0265@2|Bacteria,1NE6G@1224|Proteobacteria,4321S@68525|delta/epsilon subdivisions,2WWD7@28221|Deltaproteobacteria,2YXPK@29|Myxococcales 28221|Deltaproteobacteria O Trypsin-like peptidase domain - - - - - - - - - - - - Trypsin_2 k59_5985_1 298655.KI912266_gene4611 8.33e-101 311.0 COG0318@1|root,COG0318@2|Bacteria,2GJA2@201174|Actinobacteria 201174|Actinobacteria IQ synthetase fadD19_2 - - ko:K00666 - - - - ko00000,ko01000,ko01004 - - - AMP-binding,AMP-binding_C k59_119053_1 466088.CL42_05735 6.97e-54 178.0 COG3555@1|root,COG3555@2|Bacteria,1MW3M@1224|Proteobacteria,1RN80@1236|Gammaproteobacteria,3NJ31@468|Moraxellaceae 1236|Gammaproteobacteria O Aspartyl/Asparaginyl beta-hydroxylase lpxO - - ko:K12979 - - - - ko00000,ko01000,ko01005 - - - Asp_Arg_Hydrox k59_1417945_1 1160137.KB907307_gene239 2.8e-38 146.0 COG0318@1|root,COG0318@2|Bacteria,2GJAA@201174|Actinobacteria,4FUI3@85025|Nocardiaceae 201174|Actinobacteria IQ AMP-binding enzyme C-terminal domain - - - ko:K00666 - - - - ko00000,ko01000,ko01004 - - - AMP-binding,AMP-binding_C k59_1587410_1 1120953.AUBH01000005_gene2427 1.27e-35 136.0 COG4447@1|root,COG4447@2|Bacteria,1MVIT@1224|Proteobacteria,1RZK1@1236|Gammaproteobacteria,46979@72275|Alteromonadaceae 1236|Gammaproteobacteria G Sortilin, neurotensin receptor 3, - - - - - - - - - - - - Sortilin-Vps10 k59_1248664_1 566466.NOR53_1887 2.45e-26 110.0 COG1629@1|root,COG1629@2|Bacteria,COG4771@2|Bacteria,1MU9K@1224|Proteobacteria,1RWYZ@1236|Gammaproteobacteria,1J9VN@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P TonB dependent receptor - - - - - - - - - - - - Plug,TonB_dep_Rec k59_853505_1 999611.KI421504_gene1867 1.17e-48 174.0 COG4176@1|root,COG4176@2|Bacteria,1MUM4@1224|Proteobacteria,2TT2M@28211|Alphaproteobacteria 28211|Alphaproteobacteria P ABC-type proline glycine betaine transport system permease component - - - ko:K02001 ko02010,map02010 M00208 - - ko00000,ko00001,ko00002,ko02000 3.A.1.12 - - BPD_transp_1 k59_1023208_1 316407.85674859 9.56e-130 380.0 COG2200@1|root,COG2200@2|Bacteria,1N299@1224|Proteobacteria,1RNP4@1236|Gammaproteobacteria,3XQT7@561|Escherichia 1236|Gammaproteobacteria T cyclic-guanylate-specific phosphodiesterase activity ycgG GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 3.1.4.52 ko:K13244 - - R08991 RC00296 ko00000,ko01000 - - - CSS-motif,EAL k59_1644380_3 322710.Avin_07070 7.98e-34 130.0 COG0534@1|root,COG0534@2|Bacteria,1MV6B@1224|Proteobacteria,1RPGF@1236|Gammaproteobacteria 1236|Gammaproteobacteria V COG0534 Na -driven multidrug efflux pump dinF GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K03327 - - - - ko00000,ko02000 2.A.66.1 - - MatE k59_1644383_1 270374.MELB17_08216 8.26e-86 266.0 COG3550@1|root,COG3550@2|Bacteria,1N458@1224|Proteobacteria,1RMP7@1236|Gammaproteobacteria,4645K@72275|Alteromonadaceae 1236|Gammaproteobacteria S HipA-like C-terminal domain - - 2.7.11.1 ko:K07154 - - - - ko00000,ko01000,ko01001,ko02048 - - - Couple_hipA,HipA_C k59_1474899_1 1336233.JAEH01000029_gene350 1.23e-61 200.0 COG0306@1|root,COG0306@2|Bacteria,1QSHE@1224|Proteobacteria,1RVXY@1236|Gammaproteobacteria,2Q9J4@267890|Shewanellaceae 1236|Gammaproteobacteria P Phosphate transporter family - - - ko:K03306 - - - - ko00000 2.A.20 - - PHO4 k59_6030_1 1122137.AQXF01000007_gene3553 2.26e-115 342.0 COG0621@1|root,COG0621@2|Bacteria,1MU7N@1224|Proteobacteria,2TQUS@28211|Alphaproteobacteria 28211|Alphaproteobacteria J Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 rimO - 2.8.4.4 ko:K14441 - - R10652 RC00003,RC03217 ko00000,ko01000,ko03009 - - - Radical_SAM,TRAM,UPF0004 k59_6030_3 1313301.AUGC01000004_gene2205 4.1e-91 283.0 COG0076@1|root,COG0076@2|Bacteria,4NFUP@976|Bacteroidetes 976|Bacteroidetes E COG0076 Glutamate decarboxylase and related PLP-dependent - - 4.1.1.105,4.1.1.28 ko:K01593 ko00350,ko00360,ko00380,ko00901,ko00950,ko00965,ko01100,ko01110,ko04726,ko04728,ko05030,ko05031,ko05034,map00350,map00360,map00380,map00901,map00950,map00965,map01100,map01110,map04726,map04728,map05030,map05031,map05034 M00037,M00042 R00685,R00699,R00736,R02080,R02701,R04909 RC00299 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Pyridoxal_deC k59_1700568_1 243276.TPANIC_0345 2.35e-45 160.0 COG0472@1|root,COG0472@2|Bacteria,2J6QK@203691|Spirochaetes 203691|Spirochaetes M First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan mraY - 2.7.8.13 ko:K01000 ko00550,ko01100,ko01502,map00550,map01100,map01502 - R05629,R05630 RC00002,RC02753 ko00000,ko00001,ko01000,ko01011 9.B.146 - - Glycos_transf_4,MraY_sig1 k59_231676_1 450851.PHZ_c2409 1.42e-68 215.0 COG4126@1|root,COG4126@2|Bacteria,1MVNB@1224|Proteobacteria,2U28G@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Hydantoin racemase - - - - - - - - - - - - Asp_Glu_race k59_1023227_1 118161.KB235922_gene2022 2.69e-155 447.0 COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,1G3YK@1117|Cyanobacteria,3VNCI@52604|Pleurocapsales 1117|Cyanobacteria L DDE superfamily endonuclease - - - - - - - - - - - - DDE_3,HTH_23 k59_1248696_1 1229909.NSED_01625 1.74e-142 407.0 COG0039@1|root,arCOG00246@2157|Archaea,41S7Z@651137|Thaumarchaeota 651137|Thaumarchaeota C Belongs to the LDH MDH superfamily - - 1.1.1.37 ko:K00024 ko00020,ko00270,ko00620,ko00630,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00270,map00620,map00630,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740 R00342,R07136 RC00031 ko00000,ko00001,ko00002,ko01000 - - - Ldh_1_C,Ldh_1_N k59_909685_1 1379698.RBG1_1C00001G1725 3.23e-125 395.0 COG0841@1|root,COG0841@2|Bacteria,2NNUH@2323|unclassified Bacteria 2|Bacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family acrD - - ko:K03296,ko:K18138,ko:K18307 ko01501,ko01503,ko02024,map01501,map01503,map02024 M00644,M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000 2.A.6.2,2.A.6.2.20,2.A.6.2.32 - - ACR_tran k59_909685_2 123899.JPQP01000004_gene630 5.98e-05 45.8 COG0845@1|root,COG0845@2|Bacteria,1MU78@1224|Proteobacteria,2VINC@28216|Betaproteobacteria,3T1PI@506|Alcaligenaceae 28216|Betaproteobacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family acrA_4 - - ko:K03585 ko01501,ko01503,map01501,map01503 M00646,M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000,ko03036 2.A.6.2,8.A.1.6 - - HlyD_D23 k59_853556_1 1384054.N790_04105 7.25e-171 514.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1X41A@135614|Xanthomonadales 135614|Xanthomonadales V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_1531359_1 1283300.ATXB01000001_gene2393 2.02e-64 206.0 COG1376@1|root,COG1376@2|Bacteria,1MVYT@1224|Proteobacteria,1RMNC@1236|Gammaproteobacteria,1XE3K@135618|Methylococcales 135618|Methylococcales M PFAM YkuD domain - - - ko:K16291 - - - - ko00000,ko01002,ko01011 - - - YkuD k59_570630_1 1229909.NSED_09205 6.18e-76 236.0 COG0371@1|root,arCOG00982@2157|Archaea,41T0B@651137|Thaumarchaeota 651137|Thaumarchaeota C Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea egsA - 1.1.1.261 ko:K00096 ko00564,map00564 - R05679,R05680 RC00029 ko00000,ko00001,ko01000 - - - Fe-ADH_2 k59_514046_1 1323663.AROI01000020_gene690 6.03e-45 154.0 COG1024@1|root,COG1024@2|Bacteria,1MVPQ@1224|Proteobacteria,1SYQM@1236|Gammaproteobacteria 1236|Gammaproteobacteria I COG1024 Enoyl-CoA hydratase carnithine racemase - - - - - - - - - - - - ECH_1 k59_514046_2 1313172.YM304_17300 1.53e-67 218.0 COG0427@1|root,COG0427@2|Bacteria,2IAMG@201174|Actinobacteria,4CNYP@84992|Acidimicrobiia 84992|Acidimicrobiia C Acetyl-CoA hydrolase/transferase C-terminal domain - - - - - - - - - - - - AcetylCoA_hyd_C k59_1023244_1 1206731.BAGB01000166_gene829 3.15e-73 234.0 COG1071@1|root,COG1071@2|Bacteria,2GK3W@201174|Actinobacteria,4G0JR@85025|Nocardiaceae 201174|Actinobacteria C Dehydrogenase E1 component acoA - 1.2.4.1 ko:K00161,ko:K21416 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230 M00307 R00014,R00209,R01699,R03270 RC00004,RC00027,RC00627,RC02742,RC02744,RC02882 br01601,ko00000,ko00001,ko00002,ko01000 - - - E1_dh k59_1192391_1 349521.HCH_06112 6.21e-32 117.0 COG0036@1|root,COG0036@2|Bacteria,1MUZM@1224|Proteobacteria,1RN3K@1236|Gammaproteobacteria,1XI2U@135619|Oceanospirillales 135619|Oceanospirillales G Belongs to the ribulose-phosphate 3-epimerase family rpe - 5.1.3.1 ko:K01783 ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007 R01529 RC00540 ko00000,ko00001,ko00002,ko01000 - - - Ribul_P_3_epim k59_1192391_2 1415778.JQMM01000001_gene686 1.63e-75 233.0 COG0664@1|root,COG0664@2|Bacteria,1MXID@1224|Proteobacteria,1RMIZ@1236|Gammaproteobacteria,1J52V@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria K COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases crp GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0007154,GO:0007584,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009605,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0009991,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0016070,GO:0017076,GO:0018130,GO:0019001,GO:0019219,GO:0019222,GO:0019438,GO:0030551,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0031667,GO:0031668,GO:0031669,GO:0031670,GO:0032553,GO:0032555,GO:0032561,GO:0032774,GO:0032991,GO:0032993,GO:0034641,GO:0034645,GO:0034654,GO:0035438,GO:0036094,GO:0042221,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0045013,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0045990,GO:0046483,GO:0046983,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0051716,GO:0060255,GO:0061984,GO:0061985,GO:0065007,GO:0070887,GO:0071496,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097367,GO:0097659,GO:0140110,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:2000112,GO:2000113,GO:2001141 - ko:K10914 ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111 - - - ko00000,ko00001,ko03000 - - - Crp,cNMP_binding k59_1361805_3 1392487.JIAD01000001_gene576 8.21e-48 172.0 COG0569@1|root,COG0569@2|Bacteria,1TPNS@1239|Firmicutes,24830@186801|Clostridia,25V3H@186806|Eubacteriaceae 186801|Clostridia P Potassium transporter peripheral membrane component trkA - - ko:K03499 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - - TrkA_C,TrkA_N k59_401348_1 1250278.JQNQ01000001_gene1265 5.61e-34 134.0 COG1331@1|root,COG1331@2|Bacteria,4NFE2@976|Bacteroidetes,1HWWU@117743|Flavobacteriia 976|Bacteroidetes O Highly conserved protein containing a thioredoxin domain - - - ko:K06888 - - - - ko00000 - - - GlcNAc_2-epim,Thioredox_DsbH k59_1700605_1 1144310.PMI07_005986 4.48e-77 240.0 COG2030@1|root,COG2030@2|Bacteria,1NAYM@1224|Proteobacteria,2TRU0@28211|Alphaproteobacteria,4BF2C@82115|Rhizobiaceae 28211|Alphaproteobacteria I N-terminal half of MaoC dehydratase - - - - - - - - - - - - MaoC_dehydrat_N,MaoC_dehydratas k59_966189_1 13690.CP98_01826 7.5e-13 67.4 COG1960@1|root,COG1960@2|Bacteria,1R6EH@1224|Proteobacteria,2U2J9@28211|Alphaproteobacteria,2K0SA@204457|Sphingomonadales 204457|Sphingomonadales I Acyl-CoA dehydrogenase, middle domain - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_966189_2 1144307.PMI04_03289 9.56e-81 246.0 COG1024@1|root,COG1024@2|Bacteria,1NT5J@1224|Proteobacteria,2UPR2@28211|Alphaproteobacteria,2K2E7@204457|Sphingomonadales 204457|Sphingomonadales I Enoyl-CoA hydratase/isomerase - - - - - - - - - - - - ECH_1 k59_1135679_1 198804.BUsg_536 8.37e-10 63.9 COG0796@1|root,COG0796@2|Bacteria,1NAI2@1224|Proteobacteria,1RPU9@1236|Gammaproteobacteria,37D0V@32199|Buchnera 1236|Gammaproteobacteria M Provides the (R)-glutamate required for cell wall biosynthesis murI GO:0000270,GO:0003674,GO:0003824,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008881,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016853,GO:0016854,GO:0016855,GO:0030203,GO:0034645,GO:0036361,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0047661,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 5.1.1.3 ko:K01776 ko00471,ko01100,map00471,map01100 - R00260 RC00302 ko00000,ko00001,ko01000,ko01011 - - iAPECO1_1312.APECO1_2496,iEC042_1314.EC042_4342,iECOK1_1307.ECOK1_4443,iECS88_1305.ECS88_4426,iPC815.YPO3909,iUMN146_1321.UM146_20110,iUTI89_1310.UTI89_C4562 Asp_Glu_race k59_345271_1 1229909.NSED_09015 1.29e-144 427.0 COG1269@1|root,arCOG04138@2157|Archaea,41SRH@651137|Thaumarchaeota 651137|Thaumarchaeota C Belongs to the V-ATPase 116 kDa subunit family - - - ko:K02123 ko00190,ko01100,map00190,map01100 M00159 - - ko00000,ko00001,ko00002 3.A.2.2,3.A.2.3 - - V_ATPase_I k59_231709_1 702113.PP1Y_Mpl700 2.13e-34 133.0 COG2079@1|root,COG2079@2|Bacteria,1R5UM@1224|Proteobacteria,2U1F8@28211|Alphaproteobacteria,2K5YZ@204457|Sphingomonadales 204457|Sphingomonadales S MmgE/PrpD family - - - - - - - - - - - - MmgE_PrpD k59_514073_1 864051.BurJ1DRAFT_2685 6.86e-92 293.0 COG4117@1|root,COG4117@2|Bacteria,1R4HB@1224|Proteobacteria,2WFJG@28216|Betaproteobacteria 28216|Betaproteobacteria C Cytochrome b/b6/petB - - - - - - - - - - - - Ni_hydr_CYTB k59_909729_1 1195246.AGRI_09996 9.41e-106 324.0 COG0366@1|root,COG0366@2|Bacteria,1Q8Y2@1224|Proteobacteria,1RQV0@1236|Gammaproteobacteria,464WX@72275|Alteromonadaceae 1236|Gammaproteobacteria G Alpha amylase, catalytic domain - - - - - - - - - - - - Alpha-amylase,Alpha-amylase_C,Malt_amylase_C k59_853601_1 329726.AM1_1057 2.35e-78 249.0 2DBBI@1|root,2Z888@2|Bacteria,1GR4N@1117|Cyanobacteria 1117|Cyanobacteria S YHYH protein - - - - - - - - - - - - YHYH k59_1587492_1 1122176.KB903598_gene4620 3.54e-67 218.0 COG2124@1|root,COG2124@2|Bacteria,4NG9Z@976|Bacteroidetes 976|Bacteroidetes Q cytochrome P450 - - - - - - - - - - - - FAD_binding_1,Flavodoxin_1,NAD_binding_1,p450 k59_627346_1 555079.Toce_0868 5.22e-63 218.0 COG0587@1|root,COG0587@2|Bacteria,1TPYG@1239|Firmicutes,247U0@186801|Clostridia,42EPB@68295|Thermoanaerobacterales 186801|Clostridia L TIGRFAM DNA polymerase III, alpha subunit dnaE - 2.7.7.7 ko:K02337 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon k59_627347_1 1219049.SP5_001_01340 2.04e-06 50.1 COG0428@1|root,COG0428@2|Bacteria,1Q7FM@1224|Proteobacteria,2VDKU@28211|Alphaproteobacteria,2K5HG@204457|Sphingomonadales 204457|Sphingomonadales P transporter - - - - - - - - - - - - Zip k59_627347_2 1123270.ATUR01000002_gene2100 4.26e-16 76.6 COG3942@1|root,COG3942@2|Bacteria,1N0K8@1224|Proteobacteria,2UDGN@28211|Alphaproteobacteria,2K5G2@204457|Sphingomonadales 204457|Sphingomonadales S CHAP domain - - - - - - - - - - - - CHAP k59_288804_1 338966.Ppro_3150 9.38e-34 133.0 COG0784@1|root,COG2202@1|root,COG3829@1|root,COG4191@1|root,COG0784@2|Bacteria,COG2202@2|Bacteria,COG3829@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42MC4@68525|delta/epsilon subdivisions,2WIZU@28221|Deltaproteobacteria,43SAI@69541|Desulfuromonadales 28221|Deltaproteobacteria T Histidine kinase - - - - - - - - - - - - GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg,dCache_1 k59_1079125_1 1158146.KB907122_gene415 2.37e-08 55.8 COG0030@1|root,COG0030@2|Bacteria,1MVNU@1224|Proteobacteria,1RMHW@1236|Gammaproteobacteria,1WWC4@135613|Chromatiales 135613|Chromatiales J Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits ksgA - 2.1.1.182 ko:K02528 - - R10716 RC00003,RC03257 ko00000,ko01000,ko03009 - - - RrnaAD k59_1079125_2 291112.PAU_00568 2.33e-42 148.0 COG1995@1|root,COG1995@2|Bacteria,1MX5W@1224|Proteobacteria,1RNZV@1236|Gammaproteobacteria 1236|Gammaproteobacteria H Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) pdxA GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006081,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008614,GO:0008615,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0034641,GO:0036094,GO:0042364,GO:0042802,GO:0042816,GO:0042819,GO:0042822,GO:0042823,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046184,GO:0046483,GO:0046872,GO:0046914,GO:0048037,GO:0050570,GO:0050662,GO:0051186,GO:0051188,GO:0051287,GO:0055114,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 1.1.1.262 ko:K00097 ko00750,ko01100,map00750,map01100 M00124 R05681,R05837,R07406 RC00089,RC00675,RC01475 ko00000,ko00001,ko00002,ko01000 - - iECO111_1330.ECO111_0056 PdxA k59_909748_1 362663.ECP_4188 1.03e-102 303.0 COG1072@1|root,COG1072@2|Bacteria,1MV3M@1224|Proteobacteria,1RNXX@1236|Gammaproteobacteria,3XMR3@561|Escherichia 1236|Gammaproteobacteria F Pantothenic acid kinase coaA GO:0003674,GO:0003824,GO:0004594,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.1.33 ko:K00867 ko00770,ko01100,map00770,map01100 M00120 R02971,R03018,R04391 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - iECDH1ME8569_1439.ECDH1ME8569_3838,iECH74115_1262.ECH74115_5439,iECSE_1348.ECSE_4265,iECSF_1327.ECSF_3833,iECSP_1301.ECSP_5045,iECW_1372.ECW_m4332,iEcDH1_1363.EcDH1_4016,iEcolC_1368.EcolC_4046,iPC815.YPO3758,iSFV_1184.SFV_4047,iSFxv_1172.SFxv_4418,iWFL_1372.ECW_m4332,iZ_1308.Z5545 PRK k59_909748_2 316407.85676092 2.43e-65 206.0 COG0340@1|root,COG1654@1|root,COG0340@2|Bacteria,COG1654@2|Bacteria,1MWCC@1224|Proteobacteria,1RNGC@1236|Gammaproteobacteria,3XN5Y@561|Escherichia 1236|Gammaproteobacteria K Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon birA GO:0000166,GO:0000976,GO:0000984,GO:0001017,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003824,GO:0004077,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0006082,GO:0006464,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009305,GO:0009374,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0017053,GO:0017076,GO:0017144,GO:0018130,GO:0018271,GO:0019538,GO:0019752,GO:0019842,GO:0030554,GO:0031406,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0032991,GO:0033218,GO:0033293,GO:0034641,GO:0035639,GO:0036094,GO:0036211,GO:0042364,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043565,GO:0043603,GO:0043604,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0046983,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901681,GO:1990837 6.3.4.15 ko:K03524 ko00780,ko01100,map00780,map01100 - R01074,R05145 RC00043,RC00070,RC00096,RC02896 ko00000,ko00001,ko01000,ko03000 - - - BPL_C,BPL_LplA_LipB,HTH_11 k59_1644486_1 640081.Dsui_3445 1.64e-34 135.0 COG1807@1|root,COG1807@2|Bacteria,1P6JE@1224|Proteobacteria,2VN72@28216|Betaproteobacteria,2KU7A@206389|Rhodocyclales 206389|Rhodocyclales M Dolichyl-phosphate-mannose-protein mannosyltransferase - - - ko:K00786 - - - - ko00000,ko01000 - - - PMT_2 k59_570667_1 392499.Swit_1436 8.37e-08 58.9 COG4773@1|root,COG4773@2|Bacteria,1QTXJ@1224|Proteobacteria,2TYER@28211|Alphaproteobacteria,2KEM2@204457|Sphingomonadales 204457|Sphingomonadales P TonB dependent receptor - - - - - - - - - - - - Plug,TonB_dep_Rec k59_457934_1 1122604.JONR01000033_gene45 7.16e-75 255.0 COG2114@1|root,COG3899@1|root,COG2114@2|Bacteria,COG3899@2|Bacteria,1MUDT@1224|Proteobacteria,1S0DF@1236|Gammaproteobacteria 1236|Gammaproteobacteria K AAA ATPase domain - - - - - - - - - - - - AAA_16,BTAD,Guanylate_cyc k59_1700633_1 1229909.NSED_03080 2.25e-61 189.0 arCOG10530@1|root,arCOG10530@2157|Archaea,41T2M@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1700633_2 1229909.NSED_03065 6.14e-136 389.0 COG1938@1|root,arCOG00347@2157|Archaea,41SSA@651137|Thaumarchaeota 651137|Thaumarchaeota S PAC2 family - - - ko:K06869 - - - - ko00000 - - - PAC2 k59_231740_1 305700.B447_18879 9.23e-16 82.8 COG3210@1|root,COG3210@2|Bacteria,1QUXB@1224|Proteobacteria,2WHGF@28216|Betaproteobacteria,2KYKB@206389|Rhodocyclales 206389|Rhodocyclales U haemagglutination activity domain - - - - - - - - - - - - - k59_1023329_2 1229909.NSED_02810 1.1e-82 254.0 COG1060@1|root,arCOG00656@2157|Archaea,41SCN@651137|Thaumarchaeota 651137|Thaumarchaeota C Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2) mqnC - - - - - - - - - - - Radical_SAM k59_514101_2 1144305.PMI02_05028 1.13e-101 300.0 COG1137@1|root,COG1137@2|Bacteria,1MU8M@1224|Proteobacteria,2TR7F@28211|Alphaproteobacteria,2K0YX@204457|Sphingomonadales 204457|Sphingomonadales S ABC-type (Unclassified) transport system, ATPase component - - - ko:K06861 ko02010,map02010 M00320 - - ko00000,ko00001,ko00002,ko01000,ko02000 1.B.42.1 - - ABC_tran,BCA_ABC_TP_C k59_457948_1 1397528.Q671_06430 5.7e-129 383.0 COG0538@1|root,COG0538@2|Bacteria,1MUIB@1224|Proteobacteria,1RNT7@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Isocitrate - - 1.1.1.42 ko:K00031 ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146 M00009,M00010,M00173,M00740 R00267,R00268,R01899 RC00001,RC00084,RC00114,RC00626,RC02801 br01601,ko00000,ko00001,ko00002,ko01000 - - - Iso_dh k59_853658_1 998674.ATTE01000001_gene1999 2.63e-70 228.0 COG1160@1|root,COG1160@2|Bacteria,1MU9S@1224|Proteobacteria,1RMSF@1236|Gammaproteobacteria,4604V@72273|Thiotrichales 72273|Thiotrichales S GTPase that plays an essential role in the late steps of ribosome biogenesis der - - ko:K03977 - - - - ko00000,ko03009 - - - KH_dom-like,MMR_HSR1 k59_909784_1 406552.NJ7G_2327 7.86e-08 56.6 arCOG10710@1|root,arCOG10710@2157|Archaea,2XXDN@28890|Euryarchaeota,23VNN@183963|Halobacteria 183963|Halobacteria S Ferritin-like domain - - - - - - - - - - - - Ferritin_2 k59_1192449_1 199310.c2586 1.26e-97 304.0 COG0489@1|root,COG3206@1|root,COG0489@2|Bacteria,COG3206@2|Bacteria,1MVI9@1224|Proteobacteria,1RNB0@1236|Gammaproteobacteria,3XN7H@561|Escherichia 1236|Gammaproteobacteria DM Tyrosine-protein kinase wzc GO:0000271,GO:0003674,GO:0003824,GO:0004672,GO:0004713,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0005975,GO:0005976,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009242,GO:0009987,GO:0016020,GO:0016021,GO:0016051,GO:0016301,GO:0016310,GO:0016462,GO:0016740,GO:0016772,GO:0016773,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0018108,GO:0018193,GO:0018212,GO:0019538,GO:0031224,GO:0031226,GO:0033692,GO:0034637,GO:0034645,GO:0036211,GO:0038083,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0046377,GO:0046777,GO:0071704,GO:0071944,GO:0140096,GO:1901135,GO:1901137,GO:1901564,GO:1901576 - ko:K16692 - - - - ko00000,ko01000,ko01001 - - - AAA_31,GNVR,Wzz k59_571497_2 1297617.JPJD01000059_gene2633 3.52e-58 200.0 2C377@1|root,2Z7II@2|Bacteria,1V1QQ@1239|Firmicutes,24ETZ@186801|Clostridia 186801|Clostridia S P22 coat protein - gene protein 5 - - - - - - - - - - - - P22_CoatProtein k59_15714_1 351348.Maqu_2913 2.4e-32 130.0 COG5373@1|root,COG5373@2|Bacteria,1N08V@1224|Proteobacteria,1RTF0@1236|Gammaproteobacteria,46626@72275|Alteromonadaceae 1236|Gammaproteobacteria S Predicted membrane protein (DUF2339) - - - - - - - - - - - - DUF2339 k59_693395_1 391625.PPSIR1_09051 5.76e-28 119.0 COG0312@1|root,COG0312@2|Bacteria,1MUVW@1224|Proteobacteria,42RID@68525|delta/epsilon subdivisions,2WN9N@28221|Deltaproteobacteria,2YUME@29|Myxococcales 28221|Deltaproteobacteria S Zn-dependent proteases and their inactivated homologs pmbA - - ko:K03592 - - - - ko00000,ko01002 - - - PmbA_TldD k59_1485152_1 550540.Fbal_2970 3.45e-30 125.0 COG0642@1|root,COG0784@1|root,COG2198@1|root,COG2202@1|root,COG3829@1|root,COG5002@1|root,COG0784@2|Bacteria,COG2198@2|Bacteria,COG2202@2|Bacteria,COG2205@2|Bacteria,COG3829@2|Bacteria,COG5002@2|Bacteria,1NRP8@1224|Proteobacteria,1SKTW@1236|Gammaproteobacteria 1236|Gammaproteobacteria T Histidine kinase - - - - - - - - - - - - HATPase_c,HisKA,Hpt,PAS_3,PAS_4,PAS_9,Response_reg,dCache_1 k59_1485152_2 641491.DND132_3354 9.34e-11 68.9 COG1639@1|root,COG1639@2|Bacteria,1RAH3@1224|Proteobacteria,42PRF@68525|delta/epsilon subdivisions,2WP0E@28221|Deltaproteobacteria,2MA4G@213115|Desulfovibrionales 28221|Deltaproteobacteria T PFAM Metal-dependent hydrolase HDOD - - - - - - - - - - - - HDOD k59_1485152_3 521045.Kole_0738 3.73e-10 62.8 COG3437@1|root,COG3437@2|Bacteria,2GD4C@200918|Thermotogae 200918|Thermotogae T metal-dependent phosphohydrolase, HD sub domain - - - ko:K07814 - - - - ko00000,ko02022 - - - HD,Response_reg k59_1202162_1 1123267.JONN01000001_gene1752 0.000129 42.0 COG0099@1|root,COG0099@2|Bacteria,1RD1G@1224|Proteobacteria,2U73D@28211|Alphaproteobacteria,2K4E3@204457|Sphingomonadales 204457|Sphingomonadales J Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits rpsM - - ko:K02952 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S13 k59_1202162_2 1122137.AQXF01000006_gene955 7.22e-129 369.0 COG0563@1|root,COG0563@2|Bacteria,1MXCZ@1224|Proteobacteria,2TT6A@28211|Alphaproteobacteria 28211|Alphaproteobacteria F Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism adk - 2.7.4.3 ko:K00939 ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130 M00049 R00127,R01547,R11319 RC00002 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ADK,ADK_lid k59_1202162_3 1122137.AQXF01000006_gene956 1.72e-44 155.0 COG0201@1|root,COG0201@2|Bacteria,1MVU7@1224|Proteobacteria,2TQMT@28211|Alphaproteobacteria 28211|Alphaproteobacteria U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently secY - - ko:K03076 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5 - - SecY k59_580455_1 1498011.A0A096XUX6_9CAUD 1e-127 396.0 4QCZC@10239|Viruses,4QRH3@28883|Caudovirales 28883|Caudovirales S Bacterial DNA polymerase III alpha subunit - - - - - - - - - - - - - k59_749806_1 1094561.MEI_00797 6.29e-29 107.0 COG0335@1|root,COG0335@2|Bacteria,1RH3A@1224|Proteobacteria,2U9DF@28211|Alphaproteobacteria,48TZR@772|Bartonellaceae 28211|Alphaproteobacteria J This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site rplS GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - ko:K02884 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L19 k59_749806_2 1183438.GKIL_0117 7.95e-21 90.5 COG0164@1|root,COG0164@2|Bacteria,1G507@1117|Cyanobacteria 1117|Cyanobacteria L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids rnhB GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006281,GO:0006298,GO:0006401,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0032299,GO:0032991,GO:0033554,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576 3.1.26.4 ko:K03470 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - RNase_HII k59_749807_2 1089552.KI911559_gene3442 8.47e-34 130.0 COG0578@1|root,COG0578@2|Bacteria,1MUMY@1224|Proteobacteria,2TU11@28211|Alphaproteobacteria,2JQAF@204441|Rhodospirillales 204441|Rhodospirillales C Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family glpD - 1.1.5.3 ko:K00111 ko00564,ko01110,map00564,map01110 - R00848 RC00029 ko00000,ko00001,ko01000 - - - DAO,DAO_C k59_806946_1 1265313.HRUBRA_02301 9.73e-66 218.0 COG0204@1|root,COG0560@1|root,COG0204@2|Bacteria,COG0560@2|Bacteria,1MY51@1224|Proteobacteria,1RQYC@1236|Gammaproteobacteria,1J8AD@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria I Phosphate acyltransferases - - - - - - - - - - - - Acyltransferase,HAD k59_467254_1 709797.CSIRO_0192 1.12e-41 145.0 COG0625@1|root,COG0625@2|Bacteria,1MUN3@1224|Proteobacteria,2TTVR@28211|Alphaproteobacteria,3JU3S@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria O Belongs to the GST superfamily - - - ko:K11209 - - - - ko00000,ko01000 - - - GST_C,GST_N k59_467254_2 1266925.JHVX01000009_gene124 4.76e-14 70.9 COG1064@1|root,COG1064@2|Bacteria,1MUTT@1224|Proteobacteria,2VHZ4@28216|Betaproteobacteria,372EU@32003|Nitrosomonadales 28216|Betaproteobacteria S Alcohol dehydrogenase GroES-like domain - - 1.1.1.1 ko:K13953 ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220 - R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310 RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273 ko00000,ko00001,ko01000 - - - ADH_N k59_1597431_1 247634.GPB2148_2455 2.01e-63 211.0 COG3307@1|root,COG3307@2|Bacteria,1N225@1224|Proteobacteria,1RQWW@1236|Gammaproteobacteria,1J709@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M O-Antigen ligase - - - - - - - - - - - - Wzy_C k59_1315250_1 391615.ABSJ01000022_gene298 3.17e-116 341.0 COG3220@1|root,COG3220@2|Bacteria,1MURE@1224|Proteobacteria,1RQ9H@1236|Gammaproteobacteria,1J4P3@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S protein conserved in bacteria - - - ko:K09930 - - - - ko00000 - - - DUF692 k59_1315250_2 1177154.Y5S_00034 2.17e-20 88.2 COG3219@1|root,COG3219@2|Bacteria,1R8C9@1224|Proteobacteria,1S23S@1236|Gammaproteobacteria,1XJMH@135619|Oceanospirillales 135619|Oceanospirillales S protein conserved in bacteria - - - ko:K09929 - - - - ko00000 - - - DUF2063 k59_298794_2 414684.RC1_3379 3.58e-41 146.0 COG1752@1|root,COG1752@2|Bacteria,1MU6Z@1224|Proteobacteria,2UB6R@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Esterase of the alpha-beta hydrolase superfamily - - - - - - - - - - - - - k59_919346_1 1216976.AX27061_5183 9.54e-08 49.7 COG0023@1|root,COG0023@2|Bacteria,1MZ8T@1224|Proteobacteria,2VU7V@28216|Betaproteobacteria,3T83D@506|Alcaligenaceae 28216|Betaproteobacteria J Translation initiation factor yciH - - ko:K03113 ko03013,map03013 - - - ko00000,ko00001,ko03012 - - - SUI1 k59_1145091_1 177439.DP1142 9.68e-52 167.0 COG0098@1|root,COG0098@2|Bacteria,1MUS4@1224|Proteobacteria,42QX0@68525|delta/epsilon subdivisions,2WNBN@28221|Deltaproteobacteria,2MHKK@213118|Desulfobacterales 28221|Deltaproteobacteria J Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body rpsE GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02988 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S5,Ribosomal_S5_C k59_1145091_2 1223545.GS4_01_00590 1.89e-08 53.1 COG0256@1|root,COG0256@2|Bacteria,2IKTX@201174|Actinobacteria,4GE69@85026|Gordoniaceae 201174|Actinobacteria J This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance rplR GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0008097,GO:0008150,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0097159,GO:1901363,GO:1990904 - ko:K02881 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L18p k59_580482_1 402881.Plav_1578 3.6e-56 186.0 COG0491@1|root,COG0491@2|Bacteria,1MU8Q@1224|Proteobacteria,2TSVS@28211|Alphaproteobacteria,1JNV9@119043|Rhodobiaceae 28211|Alphaproteobacteria S Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid gloB - 3.1.2.6 ko:K01069 ko00620,map00620 - R01736 RC00004,RC00137 ko00000,ko00001,ko01000 - - - HAGH_C,Lactamase_B k59_1088933_2 1123487.KB892864_gene2215 2.69e-22 92.4 COG0792@1|root,COG0792@2|Bacteria,1N6VN@1224|Proteobacteria,2VU20@28216|Betaproteobacteria,2KX35@206389|Rhodocyclales 206389|Rhodocyclales L Belongs to the UPF0102 family - - - ko:K07460 - - - - ko00000 - - - UPF0102 k59_1541260_2 991.IW20_06725 2.71e-35 131.0 COG1233@1|root,COG1233@2|Bacteria,4NG5Y@976|Bacteroidetes,1HZF6@117743|Flavobacteriia,2NV8R@237|Flavobacterium 976|Bacteroidetes Q All-trans-retinol 13,14-reductase - - 1.3.99.23 ko:K09516 ko00830,map00830 - R07163 RC01835 ko00000,ko00001,ko01000 - - - Amino_oxidase,NAD_binding_8 k59_15768_1 158500.BV97_00601 3.66e-54 180.0 COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,2TQQ7@28211|Alphaproteobacteria,2K0FQ@204457|Sphingomonadales 204457|Sphingomonadales I Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation - - 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N k59_1654461_1 867900.Celly_0551 3.21e-36 135.0 COG0584@1|root,COG0584@2|Bacteria,4NGI1@976|Bacteroidetes,1I0PI@117743|Flavobacteriia 976|Bacteroidetes C glycerophosphoryl diester phosphodiesterase glpQ - 3.1.4.46 ko:K01126 ko00564,map00564 - R01030,R01470 RC00017,RC00425 ko00000,ko00001,ko01000 - - - GDPD,Phytase-like k59_410945_1 1122137.AQXF01000004_gene1621 1.01e-95 294.0 COG0260@1|root,COG0260@2|Bacteria,1MUIN@1224|Proteobacteria,2TSI6@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Belongs to the peptidase M17 family pepA - 3.4.11.1 ko:K01255 ko00480,ko01100,map00480,map01100 - R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 - - - Peptidase_M17 k59_1315269_1 1121124.JNIX01000002_gene80 5.24e-38 139.0 COG2962@1|root,COG2962@2|Bacteria,1MX5G@1224|Proteobacteria,2TV8D@28211|Alphaproteobacteria,2KG4P@204458|Caulobacterales 204458|Caulobacterales S TIGRFAM RarD protein, DMT superfamily transporter - - - ko:K05786 - - - - ko00000,ko02000 2.A.7.7 - - EamA k59_355387_2 279383.Q5DN15_9CAUD 2.39e-06 48.1 4QEUP@10239|Viruses,4QZ9A@35237|dsDNA viruses no RNA stage,4QPUA@28883|Caudovirales 28883|Caudovirales S D-alanyl-D-alanine carboxypeptidase - - - - - - - - - - - - - k59_1088955_1 158500.BV97_00412 8.13e-67 208.0 COG0571@1|root,COG0571@2|Bacteria,1MUQ6@1224|Proteobacteria,2TTIA@28211|Alphaproteobacteria,2K1G1@204457|Sphingomonadales 204457|Sphingomonadales J Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism rnc - 3.1.26.3 ko:K03685 ko03008,ko05205,map03008,map05205 - - - ko00000,ko00001,ko01000,ko03009,ko03019,ko03036 - - - Ribonucleas_3_3,dsrm k59_1088955_2 702113.PP1Y_AT29811 5.11e-156 445.0 COG0681@1|root,COG0681@2|Bacteria,1MXUF@1224|Proteobacteria,2TR9N@28211|Alphaproteobacteria,2K1QM@204457|Sphingomonadales 204457|Sphingomonadales U Belongs to the peptidase S26 family - - 3.4.21.89 ko:K03100 ko02024,ko03060,map02024,map03060 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_S24 k59_580507_1 1123257.AUFV01000014_gene3388 7.94e-08 52.4 COG1845@1|root,COG1845@2|Bacteria,1MUCK@1224|Proteobacteria,1RN9D@1236|Gammaproteobacteria,1X4MW@135614|Xanthomonadales 135614|Xanthomonadales C cytochrome o ubiquinol oxidase subunit III cyoC - - ko:K02299 ko00190,ko01100,map00190,map01100 M00417 - - ko00000,ko00001,ko00002 3.D.4.5 - - COX3 k59_580507_2 1292034.OR37_00404 2.08e-64 214.0 COG0843@1|root,COG0843@2|Bacteria,1MU7S@1224|Proteobacteria,2TQP1@28211|Alphaproteobacteria,2KFKY@204458|Caulobacterales 204458|Caulobacterales C Belongs to the heme-copper respiratory oxidase family - - 1.10.3.10 ko:K02298 ko00190,ko01100,map00190,map01100 M00417 R11335 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.4.5 - - COX1 k59_185563_1 391603.FBALC1_04557 4.16e-70 234.0 COG0577@1|root,COG0577@2|Bacteria,4NDUK@976|Bacteroidetes,1HX0V@117743|Flavobacteriia 976|Bacteroidetes V COG0577 ABC-type antimicrobial peptide transport system permease component - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_1710413_1 717774.Marme_0568 1.45e-28 115.0 COG0443@1|root,COG0443@2|Bacteria,1MVEN@1224|Proteobacteria,1RMDD@1236|Gammaproteobacteria,1XI2A@135619|Oceanospirillales 135619|Oceanospirillales O Heat shock 70 kDa protein dnaK - - ko:K04043 ko03018,ko04212,ko05152,map03018,map04212,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 1.A.33.1 - - HSP70 k59_1710413_2 745014.OMB55_00003160 2.97e-114 340.0 COG0484@1|root,COG0484@2|Bacteria,1MVMS@1224|Proteobacteria,1RNHY@1236|Gammaproteobacteria,1J4DE@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins dnaJ GO:0006457,GO:0008150,GO:0009987 - ko:K03686 - - - - ko00000,ko03029,ko03110 - - - DnaJ,DnaJ_C,DnaJ_CXXCXGXG k59_1202206_1 1144275.COCOR_01406 3.97e-160 473.0 COG2304@1|root,COG2304@2|Bacteria,1MUTS@1224|Proteobacteria,42Q78@68525|delta/epsilon subdivisions,2WJHK@28221|Deltaproteobacteria 28221|Deltaproteobacteria S von Willebrand factor, type A - - - ko:K07114 - - - - ko00000,ko02000 1.A.13.2.2,1.A.13.2.3 - - CarboxypepD_reg,DUF3520,VWA,vWF_A k59_1258289_1 187303.BN69_1426 3.32e-72 246.0 COG0604@1|root,COG1028@1|root,COG3321@1|root,COG0604@2|Bacteria,COG1028@2|Bacteria,COG3321@2|Bacteria,1R89Z@1224|Proteobacteria,2UR2U@28211|Alphaproteobacteria,36XER@31993|Methylocystaceae 28211|Alphaproteobacteria Q PKS_KR rkpA - - - - - - - - - - - ADH_N,ADH_zinc_N,ADH_zinc_N_2,Acyl_transf_1,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,PS-DH,ketoacyl-synt k59_1654490_3 1233488.S4T7U7_9CAUD 2.19e-28 118.0 4QAUT@10239|Viruses,4QVIM@35237|dsDNA viruses no RNA stage,4QQ7X@28883|Caudovirales,4QNET@10744|Podoviridae 10744|Podoviridae S DNA ligase (ATP) activity - - - - - - - - - - - - - k59_975243_1 1122137.AQXF01000001_gene3139 6.3e-276 781.0 COG4581@1|root,COG4581@2|Bacteria,1MVD6@1224|Proteobacteria,2TR7N@28211|Alphaproteobacteria 28211|Alphaproteobacteria L COG0513 Superfamily II DNA and RNA helicases mgpS - 3.6.4.13 ko:K17675 - - - - ko00000,ko01000,ko03029 - - - Helicase_C k59_863938_1 1552758.NC00_02855 1.14e-09 61.2 COG2264@1|root,COG2264@2|Bacteria,1MUPC@1224|Proteobacteria,1RNAR@1236|Gammaproteobacteria,1X3WM@135614|Xanthomonadales 135614|Xanthomonadales J Methylates ribosomal protein L11 prmA - - ko:K02687 - - - - ko00000,ko01000,ko03009 - - - PrmA k59_863938_2 1134474.O59_003180 1.51e-18 84.3 COG0439@1|root,COG0439@2|Bacteria,1MU4H@1224|Proteobacteria,1RMNB@1236|Gammaproteobacteria,1FGM5@10|Cellvibrio 1236|Gammaproteobacteria I Biotin carboxylase C-terminal domain accC GO:0003674,GO:0003824,GO:0004075,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0016053,GO:0016874,GO:0016879,GO:0019216,GO:0019217,GO:0019222,GO:0019752,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032787,GO:0042304,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046394,GO:0046890,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051055,GO:0062012,GO:0062014,GO:0065007,GO:0071704,GO:0072330,GO:0080090,GO:1901576 6.3.4.14,6.4.1.2 ko:K01961 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04385 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 - - iSF_1195.SF3294 Biotin_carb_C,Biotin_carb_N,CPSase_L_D2 k59_73029_1 1121405.dsmv_2195 2.61e-29 120.0 COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,42M5F@68525|delta/epsilon subdivisions,2WISF@28221|Deltaproteobacteria,2MIAR@213118|Desulfobacterales 28221|Deltaproteobacteria IQ PFAM AMP-dependent synthetase and ligase fadD - 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding,AMP-binding_C k59_1258305_1 1137799.GZ78_15055 3.43e-143 412.0 COG0045@1|root,COG0045@2|Bacteria,1MVCE@1224|Proteobacteria,1RMSU@1236|Gammaproteobacteria,1XHT9@135619|Oceanospirillales 135619|Oceanospirillales C Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit sucC - 6.2.1.5 ko:K01903 ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374,M00620 R00405,R02404 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000 - - - ATP-grasp_2,Ligase_CoA k59_1088965_1 436308.Nmar_0178 2.22e-67 206.0 arCOG00516@1|root,arCOG00516@2157|Archaea,41T43@651137|Thaumarchaeota 651137|Thaumarchaeota S Pyridoxamine 5'-phosphate - - - - - - - - - - - - Putative_PNPOx k59_1088965_2 436308.Nmar_0179 3.94e-28 102.0 arCOG08823@1|root,arCOG08823@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_807002_1 1121033.AUCF01000003_gene3221 6.54e-29 108.0 COG1493@1|root,COG1493@2|Bacteria,1NNN5@1224|Proteobacteria,2UFPB@28211|Alphaproteobacteria,2JTFD@204441|Rhodospirillales 204441|Rhodospirillales T COG1493 Serine kinase of the HPr protein, regulates carbohydrate metabolism hprK - - ko:K06023 - - - - ko00000,ko01000 - - - Hpr_kinase_C k59_807002_2 1122137.AQXF01000001_gene2971 6.91e-92 285.0 COG0642@1|root,COG2205@2|Bacteria,1N17V@1224|Proteobacteria,2TS69@28211|Alphaproteobacteria 28211|Alphaproteobacteria T Histidine kinase chvG GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 2.7.13.3 ko:K14980 ko02020,map02020 M00520 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,HisKA,Sensor_TM1,Stimulus_sens_1 k59_1428563_2 436308.Nmar_0674 5.17e-28 107.0 COG0589@1|root,arCOG02053@2157|Archaea,41TB2@651137|Thaumarchaeota 651137|Thaumarchaeota T COG0589 Universal stress protein UspA and related nucleotide-binding proteins - - - - - - - - - - - - Usp k59_1428563_5 1229909.NSED_01475 3.32e-31 115.0 COG0500@1|root,arCOG01631@2157|Archaea,41SJC@651137|Thaumarchaeota 651137|Thaumarchaeota Q RNA methylase - - - - - - - - - - - - DOT1 k59_1316289_1 1415780.JPOG01000001_gene2382 9.83e-70 230.0 COG3827@1|root,COG3827@2|Bacteria,1QQR0@1224|Proteobacteria,1S068@1236|Gammaproteobacteria,1X3QQ@135614|Xanthomonadales 135614|Xanthomonadales - - - - - - - - - - - - - - - k59_186552_1 517418.Ctha_1621 2.43e-09 63.2 COG2267@1|root,COG2267@2|Bacteria,1FF0P@1090|Chlorobi 1090|Chlorobi I Serine aminopeptidase, S33 - - - - - - - - - - - - Hydrolase_4 k59_299774_1 1144305.PMI02_02568 2.91e-24 105.0 2AEHD@1|root,314CP@2|Bacteria,1N9V6@1224|Proteobacteria,2VGGW@28211|Alphaproteobacteria,2KE3S@204457|Sphingomonadales 204457|Sphingomonadales - - - - - - - - - - - - - - - k59_920389_1 1212548.B381_13976 1.14e-116 363.0 COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,1RMUR@1236|Gammaproteobacteria,1YZRQ@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria V Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation msbA GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005319,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006855,GO:0006869,GO:0008144,GO:0008150,GO:0008289,GO:0008559,GO:0009987,GO:0010876,GO:0015221,GO:0015238,GO:0015399,GO:0015405,GO:0015437,GO:0015893,GO:0015920,GO:0016020,GO:0016021,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0034040,GO:0034204,GO:0035639,GO:0036094,GO:0042221,GO:0042493,GO:0042623,GO:0042626,GO:0042802,GO:0042908,GO:0042910,GO:0043167,GO:0043168,GO:0043190,GO:0043492,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0061024,GO:0065007,GO:0065008,GO:0071702,GO:0071840,GO:0071944,GO:0097035,GO:0097159,GO:0097367,GO:0098533,GO:0098796,GO:0098797,GO:1901264,GO:1901265,GO:1901363,GO:1901505,GO:1902494,GO:1902495,GO:1904949,GO:1990351 - ko:K11085 ko02010,map02010 - - - ko00000,ko00001,ko01000,ko02000 3.A.1.106 - iJN746.PP_4935,iPC815.YPO1395,iUMN146_1321.UM146_12980 ABC_membrane,ABC_tran k59_750801_1 270374.MELB17_15596 6.17e-70 221.0 COG0583@1|root,COG0583@2|Bacteria,1MZTA@1224|Proteobacteria,1RN7R@1236|Gammaproteobacteria,466EN@72275|Alteromonadaceae 1236|Gammaproteobacteria K Transcriptional regulator yhaJ GO:0001130,GO:0001216,GO:0003674,GO:0003700,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031334,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043254,GO:0044087,GO:0044089,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0045893,GO:0045935,GO:0046483,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051128,GO:0051130,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901576,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2000142,GO:2000144,GO:2001141 - - - - - - - - - - HTH_1,LysR_substrate k59_186562_2 1134474.O59_000060 2.31e-69 218.0 COG0253@1|root,COG0253@2|Bacteria,1MWDH@1224|Proteobacteria,1RMGV@1236|Gammaproteobacteria,1FGQB@10|Cellvibrio 1236|Gammaproteobacteria E Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan dapF - 5.1.1.7 ko:K01778 ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00527 R02735 RC00302 ko00000,ko00001,ko00002,ko01000 - - - DAP_epimerase k59_807903_1 472759.Nhal_3769 1.98e-121 368.0 COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,1RNJI@1236|Gammaproteobacteria,1WWI3@135613|Chromatiales 135613|Chromatiales L PFAM UvrD REP helicase uvrD - 3.6.4.12 ko:K03657 ko03420,ko03430,map03420,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - UvrD-helicase,UvrD_C k59_1655533_1 498211.CJA_1154 1.78e-89 280.0 COG0370@1|root,COG0370@2|Bacteria,1MUZC@1224|Proteobacteria,1RME9@1236|Gammaproteobacteria,1FG2H@10|Cellvibrio 1236|Gammaproteobacteria P Ferrous iron transport protein B C terminus feoB - - ko:K04759 - - - - ko00000,ko02000 9.A.8.1 - - FeoB_C,FeoB_N,Gate k59_242364_1 1366050.N234_07210 2e-53 179.0 COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,2VH4C@28216|Betaproteobacteria,1JZQU@119060|Burkholderiaceae 28216|Betaproteobacteria I Belongs to the thiolase family bktB - 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N k59_242364_2 1502852.FG94_03820 3e-13 70.9 COG0621@1|root,COG0621@2|Bacteria,1MU7N@1224|Proteobacteria,2VI16@28216|Betaproteobacteria,472V0@75682|Oxalobacteraceae 28216|Betaproteobacteria J Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 rimO - 2.8.4.4 ko:K14441 - - R10652 RC00003,RC03217 ko00000,ko01000,ko03009 - - - Radical_SAM,TRAM,UPF0004 k59_1655534_1 105559.Nwat_0443 1.44e-35 129.0 COG0811@1|root,COG0811@2|Bacteria,1QNJ1@1224|Proteobacteria,1RQWT@1236|Gammaproteobacteria,1WX5A@135613|Chromatiales 135613|Chromatiales U PFAM MotA TolQ ExbB proton channel - - - ko:K03561 - - - - ko00000,ko02000 1.A.30.2.1 - - MotA_ExbB k59_1655534_2 1120970.AUBZ01000001_gene3639 7.78e-23 100.0 COG0658@1|root,COG2333@1|root,COG0658@2|Bacteria,COG2333@2|Bacteria,1MUKF@1224|Proteobacteria,1RMW6@1236|Gammaproteobacteria,464JA@72275|Alteromonadaceae 1236|Gammaproteobacteria S DNA internalization-related competence protein ComEC Rec2 ycaI GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K02238 - M00429 - - ko00000,ko00002,ko02044 3.A.11.1,3.A.11.2 - - Competence,DUF4131,Lactamase_B k59_356377_1 1432050.IE4771_CH03257 4.99e-60 209.0 COG2304@1|root,COG2304@2|Bacteria,1MW8K@1224|Proteobacteria,2TV9Y@28211|Alphaproteobacteria,4B7WH@82115|Rhizobiaceae 28211|Alphaproteobacteria S Von Willebrand factor type A - - - ko:K07114 - - - - ko00000,ko02000 1.A.13.2.2,1.A.13.2.3 - - VIT,VWA_3 k59_1146235_1 316274.Haur_3648 8.99e-22 96.7 COG0791@1|root,COG3807@1|root,COG0791@2|Bacteria,COG3807@2|Bacteria,2G99E@200795|Chloroflexi,3759J@32061|Chloroflexia 200795|Chloroflexi M SH3, type 3 domain protein - - - - - - - - - - - - NLPC_P60,SH3_3 k59_581540_1 1280944.HY17_05995 3.9e-28 105.0 2EN6Y@1|root,33FUT@2|Bacteria,1NHQ0@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_807915_1 1123037.AUDE01000027_gene2097 2.02e-74 245.0 COG1629@1|root,COG4771@2|Bacteria,4NEIG@976|Bacteroidetes,1HXUG@117743|Flavobacteriia 976|Bacteroidetes P TonB-dependent receptor - - - - - - - - - - - - CarbopepD_reg_2,OMP_b-brl_3,Plug k59_638012_1 194439.CT1683 7.63e-88 283.0 COG0474@1|root,COG0474@2|Bacteria 2|Bacteria P ATPase, P-type transporting, HAD superfamily, subfamily IC - - 3.6.3.2,3.6.3.6 ko:K01531,ko:K01535 ko00190,map00190 - - - ko00000,ko00001,ko01000 3.A.3.3,3.A.3.4 - - Cation_ATPase_N,E1-E2_ATPase,Hydrolase k59_694463_1 1122194.AUHU01000014_gene1187 4.51e-47 167.0 COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,1RMBS@1236|Gammaproteobacteria,4662Z@72275|Alteromonadaceae 1236|Gammaproteobacteria NU COG2804 Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB gspE - - ko:K02454 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - T2SSE,T2SSE_N k59_694463_2 1415778.JQMM01000001_gene2239 9.27e-129 366.0 COG0717@1|root,COG0717@2|Bacteria,1MV2J@1224|Proteobacteria,1RMCD@1236|Gammaproteobacteria,1J5D8@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria F Belongs to the dCTP deaminase family dcd GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006220,GO:0006244,GO:0006253,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008829,GO:0009056,GO:0009058,GO:0009117,GO:0009141,GO:0009143,GO:0009147,GO:0009149,GO:0009166,GO:0009200,GO:0009204,GO:0009211,GO:0009213,GO:0009219,GO:0009223,GO:0009262,GO:0009264,GO:0009314,GO:0009394,GO:0009628,GO:0009987,GO:0015949,GO:0016787,GO:0016810,GO:0016814,GO:0018130,GO:0019239,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046065,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0050896,GO:0055086,GO:0071704,GO:0072527,GO:0072529,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576 3.5.4.13 ko:K01494 ko00240,ko01100,map00240,map01100 M00053 R00568,R02325 RC00074 ko00000,ko00001,ko00002,ko01000 - - iPC815.YPO1525 DCD,dUTPase k59_750831_1 316407.85675605 4.64e-111 343.0 COG0642@1|root,COG3437@1|root,COG3850@1|root,COG4999@1|root,COG2205@2|Bacteria,COG3437@2|Bacteria,COG3850@2|Bacteria,COG4999@2|Bacteria,1NRP8@1224|Proteobacteria,1SKTW@1236|Gammaproteobacteria,3XMAV@561|Escherichia 1236|Gammaproteobacteria T Member of the two-component regulatory system UvrY BarA involved in the regulation of carbon metabolism via the CsrA CsrB regulatory system. Phosphorylates UvrY, probably via a four-step phosphorelay barA GO:0000155,GO:0000160,GO:0000302,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006979,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009636,GO:0009927,GO:0009987,GO:0010033,GO:0010035,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0023014,GO:0023052,GO:0035556,GO:0036211,GO:0042221,GO:0042493,GO:0042542,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0046677,GO:0046777,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0060089,GO:0065007,GO:0070887,GO:0071310,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901700 2.7.13.3 ko:K07678 ko02020,ko02025,ko02026,ko05111,map02020,map02025,map02026,map05111 M00475 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - DUF2222,HAMP,HATPase_c,HisKA,Hpt,Response_reg k59_468414_2 243090.RB818 1.49e-15 77.8 COG3344@1|root,COG3344@2|Bacteria,2IZGP@203682|Planctomycetes 203682|Planctomycetes L Reverse transcriptase (RNA-dependent DNA polymerase) - - 2.7.7.49 ko:K00986 - - - - ko00000,ko01000 - - - GIIM,RVT_1 k59_638013_1 745310.G432_03540 2.17e-90 274.0 COG1064@1|root,COG1064@2|Bacteria,1MUTT@1224|Proteobacteria,2TTYY@28211|Alphaproteobacteria,2JZXZ@204457|Sphingomonadales 204457|Sphingomonadales S alcohol dehydrogenase - - 1.1.1.1 ko:K13953 ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220 - R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310 RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273 ko00000,ko00001,ko01000 - - - ADH_N,ADH_zinc_N k59_299799_1 465541.ATCJ01000005_gene2499 3e-05 45.4 COG0515@1|root,COG0515@2|Bacteria,2GIV0@201174|Actinobacteria 201174|Actinobacteria KLT serine threonine protein kinase - - - - - - - - - - - - Pkinase k59_365447_1 257310.BB1309 3.68e-106 325.0 COG0843@1|root,COG0843@2|Bacteria,1MU7S@1224|Proteobacteria,2VHGU@28216|Betaproteobacteria,3T1ED@506|Alcaligenaceae 28216|Betaproteobacteria C Belongs to the heme-copper respiratory oxidase family cyoB - 1.10.3.10 ko:K02298 ko00190,ko01100,map00190,map01100 M00417 R11335 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.4.5 - - COX1 k59_475551_1 436308.Nmar_1193 8.44e-111 327.0 COG1064@1|root,arCOG01455@2157|Archaea,41SK3@651137|Thaumarchaeota 651137|Thaumarchaeota C PFAM Alcohol dehydrogenase - - 1.1.1.1 ko:K13953 ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220 - R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310 RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273 ko00000,ko00001,ko01000 - - - ADH_N,ADH_zinc_N k59_308651_1 326442.PSHAb0502 3.29e-35 137.0 COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,1RMQ4@1236|Gammaproteobacteria,2Q1QS@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria IQ COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II fadD - 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding,AMP-binding_C k59_1381908_1 436308.Nmar_1489 5.18e-125 369.0 COG0016@1|root,arCOG00410@2157|Archaea,41S9U@651137|Thaumarchaeota 651137|Thaumarchaeota J Phenylalanyl-tRNA synthetase alpha subunit - - 6.1.1.20 ko:K01889 ko00970,map00970 M00359,M00360 R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_2d k59_420060_1 1123514.KB905899_gene1880 9.17e-15 72.4 COG3748@1|root,COG3748@2|Bacteria,1RFIZ@1224|Proteobacteria,1S8F8@1236|Gammaproteobacteria,4638B@72273|Thiotrichales 72273|Thiotrichales S Urate oxidase N-terminal - - - - - - - - - - - - Urate_ox_N k59_420060_2 686340.Metal_1492 1.39e-24 94.7 COG0278@1|root,COG0278@2|Bacteria,1MZ4V@1224|Proteobacteria,1S640@1236|Gammaproteobacteria,1XFF2@135618|Methylococcales 135618|Methylococcales C Belongs to the glutaredoxin family. Monothiol subfamily - - - ko:K07390 - - - - ko00000,ko03029,ko03110 - - - Glutaredoxin k59_873829_1 305900.GV64_13355 4.06e-70 221.0 COG0681@1|root,COG0681@2|Bacteria,1MXUF@1224|Proteobacteria,1RMHI@1236|Gammaproteobacteria,1XJ0T@135619|Oceanospirillales 135619|Oceanospirillales U Belongs to the peptidase S26 family lepB - 3.4.21.89 ko:K03100 ko02024,ko03060,map02024,map03060 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_S24,Peptidase_S26 k59_420062_1 682795.AciX8_3608 7.8e-47 171.0 COG1472@1|root,COG1472@2|Bacteria,3Y3WN@57723|Acidobacteria,2JIHY@204432|Acidobacteriia 204432|Acidobacteriia G PFAM glycoside hydrolase family 3 - - 3.2.1.21 ko:K05349 ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110 - R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040 RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248 ko00000,ko00001,ko01000 - GH3 - Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C k59_1043592_1 247490.KSU1_C1314 1.67e-42 157.0 COG0535@1|root,COG0535@2|Bacteria,2J2KS@203682|Planctomycetes 203682|Planctomycetes S Proto-chlorophyllide reductase 57 kD subunit - - - - - - - - - - - - PCP_red,Radical_SAM,SPASM k59_1551660_1 1122137.AQXF01000006_gene939 4.7e-21 90.5 COG0564@1|root,COG0564@2|Bacteria,1MVDX@1224|Proteobacteria,2TTQC@28211|Alphaproteobacteria 28211|Alphaproteobacteria J Responsible for synthesis of pseudouridine from uracil rluC GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360 5.4.99.24 ko:K06179 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2,S4 k59_1551660_2 1122137.AQXF01000006_gene940 6.56e-61 189.0 COG0239@1|root,COG0239@2|Bacteria,1MZNH@1224|Proteobacteria,2UBUP@28211|Alphaproteobacteria 28211|Alphaproteobacteria D Important for reducing fluoride concentration in the cell, thus reducing its toxicity crcB - - ko:K06199 - - - - ko00000,ko02000 1.A.43.1,1.A.43.2,1.A.43.3 - - CRCB k59_1551660_3 1122137.AQXF01000006_gene941 1.26e-06 48.9 2CF7S@1|root,32S1E@2|Bacteria,1R918@1224|Proteobacteria,2UBK2@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_645191_1 323097.Nham_3685 6.12e-07 56.6 COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TQTN@28211|Alphaproteobacteria,3JUK1@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria T Histidine kinase MA20_22730 - - - - - - - - - - - HAMP,HATPase_c,PAS_4,PAS_8 k59_873831_1 1117647.M5M_02505 7.1e-07 50.1 COG2227@1|root,COG2227@2|Bacteria,1MU89@1224|Proteobacteria,1RMV7@1236|Gammaproteobacteria,1J584@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway ubiG GO:0003674,GO:0003824,GO:0005488,GO:0005543,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0006950,GO:0006970,GO:0006972,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008289,GO:0008689,GO:0008757,GO:0009058,GO:0009108,GO:0009628,GO:0009651,GO:0009987,GO:0016740,GO:0016741,GO:0032259,GO:0042180,GO:0042181,GO:0042538,GO:0043167,GO:0043168,GO:0043431,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051186,GO:0051188,GO:0061542,GO:0071704,GO:1901576,GO:1901611,GO:1901661,GO:1901663 2.1.1.222,2.1.1.64 ko:K00568 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00117 R04988,R05614,R08769,R08781 RC00003,RC00392,RC01895 ko00000,ko00001,ko00002,ko01000 - - iE2348C_1286.E2348C_2376 Methyltransf_23 k59_873831_2 247633.GP2143_10167 1.81e-61 199.0 COG0546@1|root,COG0546@2|Bacteria,1RCXJ@1224|Proteobacteria,1S3VU@1236|Gammaproteobacteria,1J674@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S HAD-hyrolase-like gph GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006022,GO:0006040,GO:0006082,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008967,GO:0009254,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019752,GO:0030203,GO:0033554,GO:0034641,GO:0042578,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044260,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097172,GO:1901135,GO:1901360,GO:1901564 3.1.3.105,3.1.3.18 ko:K01091,ko:K22292 ko00520,ko00630,ko01100,ko01110,ko01130,map00520,map00630,map01100,map01110,map01130 - R01334,R11785 RC00017 ko00000,ko00001,ko01000 - - - HAD_2 k59_873831_3 61273.S3C2R8 0.000154 45.8 KOG1210@1|root,KOG1210@2759|Eukaryota,38GV8@33154|Opisthokonta,3NYA2@4751|Fungi,3QQ55@4890|Ascomycota,212Y8@147550|Sordariomycetes,3UT04@5151|Ophiostomatales 4751|Fungi Q KR domain TSC10 GO:0000234,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005741,GO:0005783,GO:0005789,GO:0005811,GO:0006464,GO:0006497,GO:0006505,GO:0006506,GO:0006629,GO:0006643,GO:0006644,GO:0006650,GO:0006661,GO:0006664,GO:0006665,GO:0006666,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008610,GO:0008654,GO:0008757,GO:0009058,GO:0009059,GO:0009247,GO:0009987,GO:0012505,GO:0016020,GO:0016491,GO:0016614,GO:0016616,GO:0016651,GO:0016740,GO:0016741,GO:0019538,GO:0019637,GO:0019867,GO:0030148,GO:0031090,GO:0031966,GO:0031967,GO:0031968,GO:0031975,GO:0031984,GO:0032259,GO:0034645,GO:0036211,GO:0042157,GO:0042158,GO:0042175,GO:0042180,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044281,GO:0044422,GO:0044424,GO:0044425,GO:0044429,GO:0044432,GO:0044444,GO:0044446,GO:0044464,GO:0045017,GO:0046467,GO:0046474,GO:0046486,GO:0046488,GO:0046519,GO:0047560,GO:0055114,GO:0071704,GO:0090407,GO:0097164,GO:0098588,GO:0098805,GO:0098827,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576,GO:1903509 1.1.1.102,1.1.1.56 ko:K00039,ko:K04708 ko00040,ko00600,ko01100,map00040,map00600,map01100 M00094,M00099 R01895,R02978 RC00089,RC00102 ko00000,ko00001,ko00002,ko01000 - - - adh_short k59_1323457_1 436308.Nmar_1519 1.58e-116 335.0 COG2101@1|root,arCOG01764@2157|Archaea,41SZD@651137|Thaumarchaeota 651137|Thaumarchaeota K General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation - - - ko:K03120 ko03022,ko05016,ko05165,ko05166,ko05168,ko05169,ko05203,map03022,map05016,map05165,map05166,map05168,map05169,map05203 - - - ko00000,ko00001,ko03000,ko03021 - - - TBP k59_1323457_2 1229909.NSED_08345 1.54e-41 140.0 arCOG04405@1|root,arCOG04405@2157|Archaea 2157|Archaea S ASCH domain - - - - - - - - - - - - ASCH k59_1607706_1 1280952.HJA_03591 3.01e-52 185.0 COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,2TRWM@28211|Alphaproteobacteria,43WSR@69657|Hyphomonadaceae 28211|Alphaproteobacteria P Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K07787 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.6.1.4 - - ACR_tran k59_814684_1 1122137.AQXF01000001_gene2900 3.01e-108 319.0 COG2171@1|root,COG2171@2|Bacteria,1MU0Y@1224|Proteobacteria,2TS3H@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Belongs to the transferase hexapeptide repeat family dapD - 2.3.1.117 ko:K00674 ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230 M00016 R04365 RC00004,RC01136 ko00000,ko00001,ko00002,ko01000 - - - Hexapep,Hexapep_2,THDPS_N_2 k59_814684_2 1122137.AQXF01000001_gene2899 5.85e-108 317.0 COG1011@1|root,COG1011@2|Bacteria,1PHPQ@1224|Proteobacteria,2TUDN@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Pyrimidine 5'-nucleotidase MA20_21845 - - ko:K07025 - - - - ko00000 - - - HAD_2 k59_365476_1 392500.Swoo_2544 4.04e-86 272.0 COG1164@1|root,COG1164@2|Bacteria,1MWYN@1224|Proteobacteria,1RS2Q@1236|Gammaproteobacteria,2QANN@267890|Shewanellaceae 1236|Gammaproteobacteria E PFAM peptidase M2, peptidyl-dipeptidase A - - 3.4.15.1 ko:K01283 ko04614,ko04924,ko05142,ko05410,map04614,map04924,map05142,map05410 - - - ko00000,ko00001,ko01000,ko01002,ko04090,ko04147 - - - Peptidase_M2 k59_1607708_1 868864.Dester_0765 1.79e-37 140.0 COG0436@1|root,COG0436@2|Bacteria,2G3PX@200783|Aquificae 200783|Aquificae E PFAM Aminotransferase class I and II dapC - - - - - - - - - - - Aminotran_1_2 k59_1551676_1 1380394.JADL01000008_gene3704 7.08e-132 386.0 COG0114@1|root,COG0114@2|Bacteria,1MUQI@1224|Proteobacteria,2TQM7@28211|Alphaproteobacteria,2JP9U@204441|Rhodospirillales 204441|Rhodospirillales C Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate fumC - 4.2.1.2 ko:K01679 ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04934,ko05200,ko05211,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200,map04934,map05200,map05211 M00009,M00011,M00173,M00376 R01082 RC00443 ko00000,ko00001,ko00002,ko01000 - - - FumaraseC_C,Lyase_1 k59_1266297_1 641526.ADIWIN_4032 6.07e-153 436.0 COG1932@1|root,COG1932@2|Bacteria,4NE06@976|Bacteroidetes,1HYNV@117743|Flavobacteriia 976|Bacteroidetes E Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine serC GO:0003674,GO:0003824,GO:0004648,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006563,GO:0006564,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.6.1.52 ko:K00831 ko00260,ko00680,ko00750,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map00750,map01100,map01120,map01130,map01200,map01230 M00020,M00124 R04173,R05085 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_5 k59_1495249_1 1469245.JFBG01000100_gene1340 6.84e-72 226.0 COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,1RNJ1@1236|Gammaproteobacteria,1WW7F@135613|Chromatiales 135613|Chromatiales EP PFAM Binding-protein-dependent transport - - - ko:K02033 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1 k59_983336_1 549.BW31_01155 2.04e-26 110.0 COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,1RMZ8@1236|Gammaproteobacteria,3VZH2@53335|Pantoea 1236|Gammaproteobacteria I Involved in the aerobic and anaerobic degradation of long-chain fatty acids via beta-oxidation cycle. Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA. It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate fadB GO:0003674,GO:0003824,GO:0003857,GO:0004165,GO:0004300,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0008692,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016491,GO:0016614,GO:0016616,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016854,GO:0016856,GO:0016860,GO:0016863,GO:0019395,GO:0019752,GO:0030258,GO:0032787,GO:0034440,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0046395,GO:0055114,GO:0071704,GO:0072329,GO:1901575 1.1.1.35,4.2.1.17,5.1.2.3,5.3.3.8 ko:K01782,ko:K01825 ko00071,ko00280,ko00281,ko00310,ko00362,ko00380,ko00410,ko00640,ko00650,ko00903,ko00930,ko01040,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00362,map00380,map00410,map00640,map00650,map00903,map00930,map01040,map01100,map01110,map01120,map01130,map01200,map01212 M00032,M00087 R01975,R03026,R03045,R03276,R04137,R04170,R04203,R04204,R04224,R04737,R04738,R04739,R04740,R04741,R04744,R04745,R04746,R04748,R04749,R04756,R05066,R05305,R06411,R06412,R06941,R06942,R07935,R07951,R08093,R08094 RC00029,RC00099,RC00117,RC00241,RC00525,RC00831,RC00834,RC00896,RC01078,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 - - iLF82_1304.LF82_0614,iNRG857_1313.NRG857_19200 3HCDH,3HCDH_N,ECH_1 k59_1721446_1 1038858.AXBA01000023_gene405 1.4e-06 48.1 2BKYI@1|root,32FF5@2|Bacteria,1MY1A@1224|Proteobacteria,2U1KI@28211|Alphaproteobacteria,3EZUF@335928|Xanthobacteraceae 28211|Alphaproteobacteria S Tripartite tricarboxylate transporter TctB family - - - - - - - - - - - - TctB k59_1721446_2 883080.HMPREF9697_00436 6.71e-51 175.0 COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,2TR4Q@28211|Alphaproteobacteria,3JT7G@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S Tripartite tricarboxylate transporter TctA family - - - ko:K07793 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.80.1 - - TctA k59_194582_1 706587.Desti_3113 3.56e-13 76.6 COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,42M01@68525|delta/epsilon subdivisions,2WJ7M@28221|Deltaproteobacteria,2MQ69@213462|Syntrophobacterales 28221|Deltaproteobacteria V Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation msbA - - ko:K06147,ko:K11085 ko02010,map02010 - - - ko00000,ko00001,ko01000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran k59_1098284_1 629773.AORY01000012_gene829 1.74e-95 284.0 28PH0@1|root,2ZC7M@2|Bacteria,1R6YG@1224|Proteobacteria,2U2A9@28211|Alphaproteobacteria,2K0JC@204457|Sphingomonadales 204457|Sphingomonadales - - - - - - - - - - - - - - - k59_1098284_2 1144305.PMI02_00895 1.04e-23 96.7 2BFHU@1|root,329BM@2|Bacteria,1RFVJ@1224|Proteobacteria,2U8MF@28211|Alphaproteobacteria,2K1CV@204457|Sphingomonadales 204457|Sphingomonadales - - - - - - - - - - - - - - - k59_815285_1 882378.RBRH_02142 6.15e-33 124.0 COG1660@1|root,COG1660@2|Bacteria,1MVX6@1224|Proteobacteria,2VIH5@28216|Betaproteobacteria,1K3DN@119060|Burkholderiaceae 28216|Betaproteobacteria S Displays ATPase and GTPase activities yhbJ - - ko:K06958 - - - - ko00000,ko03019 - - - ATP_bind_2 k59_815285_2 1123255.JHYS01000004_gene945 1.06e-18 84.0 COG2802@1|root,COG2802@2|Bacteria,1RFYH@1224|Proteobacteria,2VSA4@28216|Betaproteobacteria,4ADGM@80864|Comamonadaceae 28216|Betaproteobacteria S PFAM peptidase S16 lon domain protein - - - ko:K07157 - - - - ko00000 - - - LON_substr_bdg k59_1721448_1 436308.Nmar_0308 3.27e-57 179.0 COG2146@1|root,arCOG02852@2157|Archaea,41SSE@651137|Thaumarchaeota 651137|Thaumarchaeota P Rieske 2Fe-2S - - - ko:K05710 ko00360,ko01120,ko01220,map00360,map01120,map01220 M00545 R06782,R06783 RC00098 br01602,ko00000,ko00001,ko00002 - - - Rieske k59_1721448_3 1229909.NSED_01475 1.08e-14 71.6 COG0500@1|root,arCOG01631@2157|Archaea,41SJC@651137|Thaumarchaeota 651137|Thaumarchaeota Q RNA methylase - - - - - - - - - - - - DOT1 k59_309696_1 246197.MXAN_6551 4.21e-05 52.4 COG0747@1|root,COG0747@2|Bacteria,1N4PK@1224|Proteobacteria,42P0B@68525|delta/epsilon subdivisions,2X5XH@28221|Deltaproteobacteria,2YUKB@29|Myxococcales 28221|Deltaproteobacteria E ABC-type dipeptide transport system periplasmic component - - - ko:K02035 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - SBP_bac_5 k59_1324179_1 1121948.AUAC01000002_gene1823 4.67e-91 280.0 COG0665@1|root,COG0665@2|Bacteria,1R40G@1224|Proteobacteria,2U1VU@28211|Alphaproteobacteria 28211|Alphaproteobacteria E FAD dependent oxidoreductase - - - - - - - - - - - - DAO k59_309707_1 745310.G432_12125 4e-82 254.0 COG1609@1|root,COG1609@2|Bacteria,1MVUR@1224|Proteobacteria,2TUNV@28211|Alphaproteobacteria,2K2P2@204457|Sphingomonadales 204457|Sphingomonadales K helix_turn _helix lactose operon repressor - - - ko:K02529 - - - - ko00000,ko03000 - - - LacI,Peripla_BP_3 k59_476311_1 1112216.JH594425_gene2920 4.7e-39 150.0 COG1472@1|root,COG1472@2|Bacteria,1MVIV@1224|Proteobacteria,2TS28@28211|Alphaproteobacteria,2K11N@204457|Sphingomonadales 204457|Sphingomonadales G Glycosyl hydrolase family 3 C-terminal domain - - 3.2.1.21 ko:K05349 ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110 - R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040 RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248 ko00000,ko00001,ko01000 - GH3 - Glyco_hydro_3,Glyco_hydro_3_C k59_1155308_1 1123368.AUIS01000017_gene2580 2.58e-06 52.0 COG1381@1|root,COG1381@2|Bacteria,1RHIC@1224|Proteobacteria,1RN8Y@1236|Gammaproteobacteria,2NC6H@225057|Acidithiobacillales 225057|Acidithiobacillales L Involved in DNA repair and RecF pathway recombination recO - - ko:K03584 ko03440,map03440 - - - ko00000,ko00001,ko03400 - - - RecO_C,RecO_N k59_1721476_1 454957.IA64_10300 3.43e-25 110.0 COG0642@1|root,COG0745@1|root,COG0745@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,1SKTW@1236|Gammaproteobacteria,1X3RD@135614|Xanthomonadales 135614|Xanthomonadales T Histidine kinase rpfC - 2.7.13.3 ko:K10715 ko02020,ko02024,map02020,map02024 M00517 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA,Hpt,Response_reg k59_84116_2 658187.LDG_8108 3.34e-113 332.0 COG0396@1|root,COG0396@2|Bacteria,1MUGK@1224|Proteobacteria,1RPFE@1236|Gammaproteobacteria,1JCFI@118969|Legionellales 118969|Legionellales O ABC transporter sufC - - ko:K09013 - - - - ko00000,ko02000 - - - ABC_tran k59_194607_1 1349767.GJA_2052 7.92e-103 310.0 COG0626@1|root,COG0626@2|Bacteria,1MU57@1224|Proteobacteria,2VHAC@28216|Betaproteobacteria,473FV@75682|Oxalobacteraceae 28216|Betaproteobacteria E Cys/Met metabolism PLP-dependent enzyme metC - 2.5.1.48,4.4.1.1,4.4.1.11,4.4.1.8 ko:K01739,ko:K01758,ko:K01760,ko:K01761 ko00260,ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00260,map00270,map00450,map00920,map01100,map01110,map01130,map01230 M00017,M00338 R00654,R00782,R00999,R01001,R01286,R01288,R02408,R02508,R03217,R03260,R04770,R04930,R04941,R04944,R04945,R04946,R09366 RC00020,RC00056,RC00069,RC00196,RC00348,RC00382,RC00420,RC00488,RC00710,RC01209,RC01210,RC01245,RC02303,RC02848,RC02866 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Cys_Met_Meta_PP k59_928463_1 1226325.HMPREF1548_01680 4.06e-11 68.2 COG2199@1|root,COG3437@1|root,COG2199@2|Bacteria,COG3437@2|Bacteria,1UQJH@1239|Firmicutes,248UM@186801|Clostridia,36DPS@31979|Clostridiaceae 186801|Clostridia T domain protein rpfG3 - - ko:K07814 - - - - ko00000,ko02022 - - - GAF_2,GGDEF,HD,HD_5,Response_reg k59_1155309_1 1232683.ADIMK_0828 3.15e-45 164.0 COG1492@1|root,COG1492@2|Bacteria,1MUFY@1224|Proteobacteria,1RP8G@1236|Gammaproteobacteria,464HY@72275|Alteromonadaceae 1236|Gammaproteobacteria H Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation cobQ GO:0003674,GO:0003824,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009235,GO:0009236,GO:0009987,GO:0017144,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042364,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.5.10 ko:K02232 ko00860,ko01100,map00860,map01100 M00122 R05225 RC00010,RC01302 ko00000,ko00001,ko00002,ko01000 - - - AAA_26,CbiA,GATase_3 k59_476324_1 1122137.AQXF01000003_gene2087 3.2e-37 137.0 COG0624@1|root,COG0624@2|Bacteria,1MWJS@1224|Proteobacteria,2TUHT@28211|Alphaproteobacteria 28211|Alphaproteobacteria E COG0624 Acetylornithine deacetylase Succinyl-diaminopimelate desuccinylase and related deacylases - - - - - - - - - - - - M20_dimer,Peptidase_M20,Peptidase_M28 k59_476324_2 491952.Mar181_2756 5.79e-15 72.4 COG0692@1|root,COG0692@2|Bacteria,1MV80@1224|Proteobacteria,1RPDH@1236|Gammaproteobacteria,1XI06@135619|Oceanospirillales 135619|Oceanospirillales L Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine ung - 3.2.2.27 ko:K03648 ko03410,ko05340,map03410,map05340 - - - ko00000,ko00001,ko01000,ko03400 - - - UDG k59_1608808_1 1280001.BAOA01000022_gene546 3.08e-47 169.0 COG3746@1|root,COG3746@2|Bacteria,1MY3M@1224|Proteobacteria,1RZ3M@1236|Gammaproteobacteria,1XVU4@135623|Vibrionales 135623|Vibrionales P phosphate-selective porin O and P - - - - - - - - - - - - - k59_531855_1 1392498.JQLH01000001_gene1826 4.98e-67 219.0 COG0415@1|root,COG0415@2|Bacteria,4NEDW@976|Bacteroidetes,1HXRR@117743|Flavobacteriia,2PGIN@252356|Maribacter 976|Bacteroidetes L DNA photolyase phr - 4.1.99.3 ko:K01669 - - - - ko00000,ko01000,ko03400 - - - DNA_photolyase,FAD_binding_7 k59_1663910_1 1415775.U729_758 3.84e-18 88.2 COG2265@1|root,COG2265@2|Bacteria,1TP4H@1239|Firmicutes,248B4@186801|Clostridia,36EBZ@31979|Clostridiaceae 186801|Clostridia J Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family rumA - 2.1.1.190 ko:K03215 - - - - ko00000,ko01000,ko03009 - - - TRAM,tRNA_U5-meth_tr k59_1044667_2 686340.Metal_3304 2.91e-28 104.0 COG0186@1|root,COG0186@2|Bacteria,1MZIK@1224|Proteobacteria,1S8SS@1236|Gammaproteobacteria,1XFGP@135618|Methylococcales 135618|Methylococcales J One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA rpsQ - - ko:K02961 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S17 k59_1044667_3 305700.B447_16006 4.95e-17 75.1 COG0093@1|root,COG0093@2|Bacteria,1RCWZ@1224|Proteobacteria,2VR2N@28216|Betaproteobacteria,2KWBZ@206389|Rhodocyclales 206389|Rhodocyclales J Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome rplN - - ko:K02874 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L14 k59_1212925_1 1266909.AUAG01000063_gene1806 8.01e-106 317.0 COG3547@1|root,COG3547@2|Bacteria,1NGR7@1224|Proteobacteria,1RMF9@1236|Gammaproteobacteria,1WZPM@135613|Chromatiales 135613|Chromatiales L Transposase IS116/IS110/IS902 family - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_309750_1 269799.Gmet_1348 1.48e-70 221.0 COG0637@1|root,COG0637@2|Bacteria,1PUMZ@1224|Proteobacteria,42W4B@68525|delta/epsilon subdivisions,2WP0P@28221|Deltaproteobacteria,43UMI@69541|Desulfuromonadales 28221|Deltaproteobacteria S TIGRFAM HAD-superfamily hydrolase, subfamily IA, variant 3 - - 5.4.2.6 ko:K01838 ko00500,map00500 - R02728,R11310 RC00408 ko00000,ko00001,ko01000 - - - HAD_2 k59_531864_1 316407.85675819 6.26e-119 360.0 COG1032@1|root,COG1032@2|Bacteria,1MUG3@1224|Proteobacteria,1RN9V@1236|Gammaproteobacteria,3XN2Q@561|Escherichia 1236|Gammaproteobacteria C UPF0313 protein YgiQ ygiQ - - - - - - - - - - - DUF3362,Radical_SAM,Radical_SAM_N k59_1324217_1 756272.Plabr_3568 2.84e-19 92.0 2CGZ8@1|root,31WRF@2|Bacteria,2J256@203682|Planctomycetes 203682|Planctomycetes - - - - - - - - - - - - - - - k59_1608828_1 436308.Nmar_1338 4.06e-54 182.0 COG4742@1|root,arCOG04362@2157|Archaea,41SGE@651137|Thaumarchaeota 651137|Thaumarchaeota K Transcriptional regulator - - - - - - - - - - - - HTH_20,HTH_5 k59_1608831_1 234267.Acid_7732 2.26e-109 350.0 COG0514@1|root,COG0550@1|root,COG0514@2|Bacteria,COG0550@2|Bacteria,3Y363@57723|Acidobacteria 57723|Acidobacteria L TIGRFAM ATP-dependent DNA helicase, RecQ family - - 3.6.4.12,5.99.1.2 ko:K03169,ko:K03654 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03032,ko03400 - - - DEAD,HRDC,Helicase_C,RecQ_Zn_bind k59_928494_1 857087.Metme_0076 4.61e-36 126.0 COG3791@1|root,COG3791@2|Bacteria,1N0W7@1224|Proteobacteria,1SC8R@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Glutathione-dependent formaldehyde-activating enzyme - - - - - - - - - - - - GFA k59_1155354_1 159087.Daro_0331 2.14e-95 283.0 COG0094@1|root,COG0094@2|Bacteria,1MUU9@1224|Proteobacteria,2VHCP@28216|Betaproteobacteria,2KUBB@206389|Rhodocyclales 206389|Rhodocyclales J This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits rplE - - ko:K02931 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L5,Ribosomal_L5_C k59_1212978_1 1088721.NSU_1360 3.98e-93 287.0 COG2939@1|root,COG2939@2|Bacteria,1MW05@1224|Proteobacteria,2TS7R@28211|Alphaproteobacteria,2K2R0@204457|Sphingomonadales 204457|Sphingomonadales E Serine carboxypeptidase - - - - - - - - - - - - Peptidase_S10 k59_1155360_1 1117647.M5M_07390 3.73e-29 110.0 COG2606@1|root,COG2606@2|Bacteria,1N10Y@1224|Proteobacteria,1SAQE@1236|Gammaproteobacteria,1J6XR@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Aminoacyl-tRNA editing domain - - - ko:K19055 - - - - ko00000,ko01000,ko03016 - - - tRNA_edit k59_1155360_2 314278.NB231_07482 4.39e-30 120.0 COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,1RMUR@1236|Gammaproteobacteria,1WW7H@135613|Chromatiales 135613|Chromatiales V ABC transporter transmembrane region - - - ko:K06147 - - - - ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran k59_1496421_1 338966.Ppro_2545 6.91e-39 147.0 COG0768@1|root,COG0768@2|Bacteria,1MV8C@1224|Proteobacteria,42M1S@68525|delta/epsilon subdivisions,2WJ02@28221|Deltaproteobacteria,43U7Y@69541|Desulfuromonadales 28221|Deltaproteobacteria M PFAM penicillin-binding protein transpeptidase mrdA - 3.4.16.4 ko:K05515 ko00550,ko01501,map00550,map01501 - - - ko00000,ko00001,ko01000,ko01011 - - iAF987.Gmet_0928 PBP_dimer,Transpeptidase k59_646027_1 1333998.M2A_2644 1.72e-78 246.0 COG1024@1|root,COG1024@2|Bacteria,1MXZ2@1224|Proteobacteria,2TRQ8@28211|Alphaproteobacteria 28211|Alphaproteobacteria I Enoyl-CoA hydratase MA20_25215 - - - - - - - - - - - ECH_1 k59_646027_2 999550.KI421507_gene2810 2.93e-07 54.7 COG3393@1|root,COG3393@2|Bacteria,1RKK4@1224|Proteobacteria,2U63H@28211|Alphaproteobacteria 28211|Alphaproteobacteria S acetyltransferase, GNAT family - - - - - - - - - - - - Acetyltransf_1,Acetyltransf_9,FR47 k59_874991_1 391937.NA2_16393 4.53e-38 140.0 COG1477@1|root,COG1477@2|Bacteria,1MW6K@1224|Proteobacteria,2TT9G@28211|Alphaproteobacteria,43JWR@69277|Phyllobacteriaceae 28211|Alphaproteobacteria H Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein apbE - 2.7.1.180 ko:K03734 - - - - ko00000,ko01000 - - - ApbE k59_1044738_1 1265313.HRUBRA_01636 1.02e-113 337.0 COG4307@1|root,COG4307@2|Bacteria,1MW31@1224|Proteobacteria,1RRA7@1236|Gammaproteobacteria,1JA5V@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Putative zinc-binding metallo-peptidase - - - - - - - - - - - - Peptidase_Mx,zinc-ribbon_6 k59_1267409_1 258052.JNYV01000002_gene1506 0.000109 47.4 COG0685@1|root,COG0685@2|Bacteria,2GJ6U@201174|Actinobacteria 201174|Actinobacteria E Methylenetetrahydrofolate reductase - - - - - - - - - - - - MTHFR,MTHFR_C k59_1267409_2 1347087.CBYO010000007_gene1011 1.19e-07 53.9 COG0800@1|root,COG0800@2|Bacteria,1TS0F@1239|Firmicutes,4HDWW@91061|Bacilli 91061|Bacilli G KDPG and KHG aldolase eda - 4.1.2.14,4.1.3.42 ko:K01625 ko00030,ko00630,ko01100,ko01120,ko01200,map00030,map00630,map01100,map01120,map01200 M00008,M00061,M00308,M00631 R00470,R05605 RC00307,RC00308,RC00435 ko00000,ko00001,ko00002,ko01000 - - - Aldolase k59_366698_1 1122207.MUS1_06645 5.12e-89 275.0 COG2230@1|root,COG2230@2|Bacteria,1MX3U@1224|Proteobacteria,1RNID@1236|Gammaproteobacteria,1XHND@135619|Oceanospirillales 135619|Oceanospirillales M COG2230 Cyclopropane fatty acid synthase and related methyltransferases - - 2.1.1.79 ko:K00574 - - - - ko00000,ko01000 - - - CMAS k59_1608883_1 1286170.RORB6_20895 1.21e-13 65.5 COG0198@1|root,COG0198@2|Bacteria,1MZQD@1224|Proteobacteria,1S973@1236|Gammaproteobacteria 1236|Gammaproteobacteria J One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit rplX GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02895 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - KOW,ribosomal_L24 k59_1608883_2 316407.85676731 7.31e-82 242.0 COG0093@1|root,COG0093@2|Bacteria,1RCWZ@1224|Proteobacteria,1S3Z3@1236|Gammaproteobacteria,3XPKB@561|Escherichia 1236|Gammaproteobacteria J Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome rplN GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070180,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02874 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L14 k59_420849_1 1454004.AW11_03350 3.43e-73 241.0 COG5009@1|root,COG5009@2|Bacteria,1MU5A@1224|Proteobacteria,2VHXF@28216|Betaproteobacteria,1KPP9@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria M penicillin-binding protein mrcA - 2.4.1.129,3.4.16.4 ko:K05366 ko00550,ko01100,ko01501,map00550,map01100,map01501 - - - ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 - PCB_OB,Transgly,Transpeptidase k59_815364_1 756067.MicvaDRAFT_4927 7.17e-56 199.0 COG0515@1|root,COG0642@1|root,COG2199@1|root,COG3899@1|root,COG0515@2|Bacteria,COG2205@2|Bacteria,COG3706@2|Bacteria,COG3899@2|Bacteria,1GBKM@1117|Cyanobacteria,1H7D9@1150|Oscillatoriales 1117|Cyanobacteria KLT Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - AAA_16,GAF,HATPase_c,HisKA,Pkinase,Response_reg k59_1044749_1 1397527.Q670_11735 3.62e-59 199.0 COG2124@1|root,COG2124@2|Bacteria,1MV75@1224|Proteobacteria,1RR6Y@1236|Gammaproteobacteria,1XJCM@135619|Oceanospirillales 135619|Oceanospirillales C cytochrome P450 - - - - - - - - - - - - p450 k59_531910_1 553385.JEMF01000111_gene1087 1.25e-80 247.0 COG2801@1|root,COG2801@2|Bacteria,1MVC8@1224|Proteobacteria,1RXYF@1236|Gammaproteobacteria,1XHWD@135619|Oceanospirillales 135619|Oceanospirillales L HTH-like domain - - - ko:K07497 - - - - ko00000 - - - HTH_21,rve,rve_3 k59_1496451_1 566466.NOR53_3216 1.15e-115 351.0 COG4770@1|root,COG4770@2|Bacteria,1P6RE@1224|Proteobacteria,1RM95@1236|Gammaproteobacteria,1J8VB@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria F Pfam:CPSase_L_chain mccA - 6.4.1.4,6.4.1.5 ko:K01968,ko:K13777 ko00280,ko00281,ko01100,map00280,map00281,map01100 M00036 R03494,R04138 RC00367,RC00942 ko00000,ko00001,ko00002,ko01000 - - - Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2 k59_531914_1 1229909.NSED_00115 4.44e-89 270.0 COG0702@1|root,arCOG03015@2157|Archaea,41T19@651137|Thaumarchaeota 651137|Thaumarchaeota M NAD(P)H-binding - - 1.6.5.3,1.6.99.3 ko:K00329,ko:K00356 ko00190,map00190 - R11945 RC00061 ko00000,ko00001,ko01000 - - - NAD_binding_10 k59_481495_1 1121405.dsmv_1910 4.25e-31 124.0 COG0621@1|root,COG0621@2|Bacteria,1MU7N@1224|Proteobacteria,42MRJ@68525|delta/epsilon subdivisions,2WITA@28221|Deltaproteobacteria,2MISV@213118|Desulfobacterales 28221|Deltaproteobacteria J Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 rimO - 2.8.4.4 ko:K14441 - - R10652 RC00003,RC03217 ko00000,ko01000,ko03009 - - - Radical_SAM,TRAM,UPF0004 k59_763809_1 1279017.AQYJ01000028_gene2346 2.69e-40 140.0 28H65@1|root,2Z7IN@2|Bacteria,1Q4IY@1224|Proteobacteria,1RZHE@1236|Gammaproteobacteria,46703@72275|Alteromonadaceae 1236|Gammaproteobacteria - - - - - - - - - - - - - - Phage_lambda_P k59_259131_2 1229909.NSED_01175 8.51e-20 84.0 COG1581@1|root,arCOG01753@2157|Archaea,41SQ4@651137|Thaumarchaeota 651137|Thaumarchaeota K Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes - - - ko:K03622 - - - - ko00000 - - - Alba k59_317233_1 316407.85676875 6.03e-94 286.0 COG2704@1|root,COG2704@2|Bacteria,1MVHH@1224|Proteobacteria,1RPTE@1236|Gammaproteobacteria,3XMXI@561|Escherichia 1236|Gammaproteobacteria S Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane dcuB GO:0003674,GO:0005215,GO:0005310,GO:0005342,GO:0005469,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0006835,GO:0006855,GO:0008150,GO:0008509,GO:0008514,GO:0015075,GO:0015138,GO:0015141,GO:0015238,GO:0015291,GO:0015297,GO:0015318,GO:0015556,GO:0015711,GO:0015740,GO:0015741,GO:0015744,GO:0015849,GO:0015893,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0042221,GO:0042493,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071422,GO:0071702,GO:0071944,GO:0098656,GO:1903825,GO:1905039 - ko:K07792 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.13.1 - iUMNK88_1353.UMNK88_4987 DcuA_DcuB k59_425974_1 290397.Adeh_0235 8.55e-74 240.0 COG0696@1|root,COG0696@2|Bacteria,1MUQ1@1224|Proteobacteria,42N6C@68525|delta/epsilon subdivisions,2WJ66@28221|Deltaproteobacteria,2YWA3@29|Myxococcales 28221|Deltaproteobacteria G Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate gpmI - 5.4.2.12 ko:K15633 ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003 R01518 RC00536 ko00000,ko00001,ko00002,ko01000 - - - Metalloenzyme,Phosphodiest,iPGM_N k59_425974_2 1200792.AKYF01000009_gene3175 3.39e-06 47.0 COG0799@1|root,COG0799@2|Bacteria,1VA2Z@1239|Firmicutes,4HKEJ@91061|Bacilli,26Y7E@186822|Paenibacillaceae 91061|Bacilli J Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation rsfS GO:0003674,GO:0005488,GO:0006417,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0017148,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0034248,GO:0034249,GO:0043021,GO:0043023,GO:0044087,GO:0044877,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0080090,GO:0090069,GO:0090071,GO:2000112,GO:2000113 - ko:K09710 - - - - ko00000,ko03009 - - - RsfS k59_317237_1 1229909.NSED_04885 8.37e-14 65.5 arCOG11517@1|root,arCOG11517@2157|Archaea,41TAE@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1391310_2 589865.DaAHT2_1974 2.68e-16 80.9 COG0612@1|root,COG0612@2|Bacteria,1MVST@1224|Proteobacteria,42NYP@68525|delta/epsilon subdivisions,2WIPJ@28221|Deltaproteobacteria,2MIG6@213118|Desulfobacterales 28221|Deltaproteobacteria S Belongs to the peptidase M16 family - - - ko:K07263 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M16,Peptidase_M16_C k59_712619_1 710421.Mycch_3649 5.06e-23 97.4 COG2159@1|root,COG2159@2|Bacteria,2GKG2@201174|Actinobacteria,234EQ@1762|Mycobacteriaceae 201174|Actinobacteria S amidohydrolase - - - - - - - - - - - - Amidohydro_2 k59_712619_2 247634.GPB2148_2088 6.59e-13 72.4 COG2717@1|root,COG2717@2|Bacteria,1R4CY@1224|Proteobacteria,1SHX8@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain - - - - - - - - - - - - Ferric_reduct k59_426596_1 441620.Mpop_5093 6.2e-24 106.0 COG0389@1|root,COG0389@2|Bacteria,1MU5X@1224|Proteobacteria,2TQVR@28211|Alphaproteobacteria,1JTHG@119045|Methylobacteriaceae 28211|Alphaproteobacteria L Nucleotidyltransferase DNA polymerase involved in DNA repair - - - ko:K14161 - - - - ko00000,ko03400 - - - IMS,IMS_C k59_712625_1 436308.Nmar_1291 9.3e-164 465.0 COG4992@1|root,arCOG00914@2157|Archaea,41SC8@651137|Thaumarchaeota 651137|Thaumarchaeota E Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family lysJ - - ko:K05830 ko00220,ko00300,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01130,map01210,map01230 M00031,M00763 R09778,R10932 RC00006,RC00062 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 k59_1104337_1 1049564.TevJSym_at00640 3.24e-27 108.0 COG0004@1|root,COG0004@2|Bacteria,1NR9F@1224|Proteobacteria,1RNKF@1236|Gammaproteobacteria,1J4I3@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P Ammonium Transporter amtB - - ko:K03320 - - - - ko00000,ko02000 1.A.11 - - Ammonium_transp k59_318168_1 159087.Daro_3373 3.09e-12 65.9 COG0805@1|root,COG0805@2|Bacteria,1MVAY@1224|Proteobacteria,2VI2H@28216|Betaproteobacteria,2KUWA@206389|Rhodocyclales 206389|Rhodocyclales U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides tatC - - ko:K03118 ko03060,ko03070,map03060,map03070 M00336 - - ko00000,ko00001,ko00002,ko02044 2.A.64 - - TatC k59_318168_2 391038.Bphy_2747 1.34e-26 104.0 COG1826@1|root,COG1826@2|Bacteria,1N73F@1224|Proteobacteria,2VT7B@28216|Betaproteobacteria,1K5T3@119060|Burkholderiaceae 28216|Betaproteobacteria U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation tatB - - ko:K03117 ko03060,ko03070,map03060,map03070 M00336 - - ko00000,ko00001,ko00002,ko02044 2.A.64 - - MttA_Hcf106 k59_318168_3 1235457.C404_26975 1.85e-23 91.7 COG1826@1|root,COG1826@2|Bacteria,1N6S4@1224|Proteobacteria,2VVT6@28216|Betaproteobacteria,1K977@119060|Burkholderiaceae 28216|Betaproteobacteria U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system tatA - - ko:K03116 ko03060,ko03070,map03060,map03070 M00336 - - ko00000,ko00001,ko00002,ko02044 2.A.64 - - MttA_Hcf106 k59_318168_4 1000565.METUNv1_02439 3.92e-20 84.0 COG0537@1|root,COG0537@2|Bacteria,1RDCJ@1224|Proteobacteria,2VSMS@28216|Betaproteobacteria,2KWJU@206389|Rhodocyclales 206389|Rhodocyclales FG COG0537 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases - - - ko:K02503 - - - - ko00000,ko04147 - - - DcpS_C,HIT k59_1391319_2 938288.HG326227_gene386 4.89e-09 62.8 COG0635@1|root,COG0635@2|Bacteria,1TREM@1239|Firmicutes,247JT@186801|Clostridia,267TZ@186813|unclassified Clostridiales 186801|Clostridia H Elongator protein 3, MiaB family, Radical SAM hemZ - - - - - - - - - - - Radical_SAM k59_1162987_1 314607.KB13_1001 3.59e-05 47.0 COG1825@1|root,COG1825@2|Bacteria,1RDH0@1224|Proteobacteria,2VQNU@28216|Betaproteobacteria,1KPYI@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria J This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance ctc - - ko:K02897 ko03010,map03010 M00178 - - ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L25p,Ribosomal_TL5_C k59_1162987_2 1313172.YM304_33090 3.55e-20 89.0 COG0462@1|root,COG0462@2|Bacteria,2GJ9S@201174|Actinobacteria,4CMVQ@84992|Acidimicrobiia 84992|Acidimicrobiia F Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) prs - 2.7.6.1 ko:K00948 ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230 M00005 R01049 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - Pribosyl_synth,Pribosyltran_N k59_1504385_1 930166.CD58_06270 1.1e-39 147.0 COG5301@1|root,COG5301@2|Bacteria,1MWNN@1224|Proteobacteria 1224|Proteobacteria M tail fiber protein - - - - - - - - - - - - Collar,DUF3751,Phage_fiber_2 k59_1504385_3 1572704.A0A0D3MWE6_9CAUD 0.000812 48.9 4QAMU@10239|Viruses,4QPEV@28883|Caudovirales,4QI0J@10662|Myoviridae 10662|Myoviridae S Baseplate J-like protein - GO:0005575,GO:0019012,GO:0044423,GO:0098015,GO:0098025 - - - - - - - - - - - k59_1504385_4 556268.OFAG_00791 1.22e-47 162.0 29881@1|root,2ZVDS@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_1219828_1 1122137.AQXF01000005_gene1076 9.82e-114 341.0 COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,2TS7G@28211|Alphaproteobacteria 28211|Alphaproteobacteria S COG0488 ATPase components of ABC transporters with duplicated ATPase domains chvD - - ko:K15738 - - - - ko00000,ko02000 3.A.1.120.6 - - ABC_tran,ABC_tran_Xtn k59_35094_1 1229909.NSED_02970 1.17e-93 284.0 COG0412@1|root,arCOG10350@1|root,arCOG01659@2157|Archaea,arCOG10350@2157|Archaea,41T1E@651137|Thaumarchaeota 651137|Thaumarchaeota Q Chlorophyllase - - 3.1.1.45 ko:K01061 ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130 - R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222 RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686 ko00000,ko00001,ko01000 - - - DLH k59_883109_2 977880.RALTA_A1493 4.03e-59 199.0 COG0354@1|root,COG0354@2|Bacteria,1N852@1224|Proteobacteria,2VK2D@28216|Betaproteobacteria,1K0KG@119060|Burkholderiaceae 28216|Betaproteobacteria S Belongs to the GcvT family ygfZ - - ko:K06980 - - - - ko00000,ko03016 - - - GCV_T,GCV_T_C k59_482102_1 443255.SCLAV_5255 6.96e-57 194.0 COG4948@1|root,COG4948@2|Bacteria,2GJJR@201174|Actinobacteria 201174|Actinobacteria M Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB) - - 5.5.1.1 ko:K01856 ko00361,ko00362,ko00364,ko00623,ko01100,ko01120,ko01220,map00361,map00362,map00364,map00623,map01100,map01120,map01220 M00568 R05300,R05390,R06989,R08116,R09229 RC00903,RC01038,RC01108,RC01321,RC01356 ko00000,ko00001,ko00002,ko01000 - - - MR_MLE_C,MR_MLE_N k59_1561634_1 1229909.NSED_09685 1.74e-74 226.0 COG0071@1|root,arCOG01833@2157|Archaea,41SPJ@651137|Thaumarchaeota 651137|Thaumarchaeota O Belongs to the small heat shock protein (HSP20) family - - - ko:K13993 ko04141,map04141 - - - ko00000,ko00001,ko03110 - - - HSP20 k59_1561634_2 1229909.NSED_09680 4.59e-121 349.0 arCOG01806@1|root,arCOG01806@2157|Archaea,41T2B@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_599557_1 1122137.AQXF01000006_gene725 1.58e-106 344.0 COG1196@1|root,COG1196@2|Bacteria,1MVEP@1224|Proteobacteria,2TR50@28211|Alphaproteobacteria 28211|Alphaproteobacteria D domain, Protein - - - - - - - - - - - - Apolipoprotein k59_537251_1 177437.HRM2_44910 1.04e-10 63.9 COG3133@1|root,COG3133@2|Bacteria,1RA1D@1224|Proteobacteria,42TU5@68525|delta/epsilon subdivisions,2WQHI@28221|Deltaproteobacteria,2MJT9@213118|Desulfobacterales 28221|Deltaproteobacteria M Glycine zipper 2TM domain - - - ko:K06077 - - - - ko00000 - - - Rick_17kDa_Anti k59_883118_1 1125973.JNLC01000010_gene1411 1.69e-100 301.0 COG1073@1|root,COG1073@2|Bacteria,1MXJ3@1224|Proteobacteria,2TVHP@28211|Alphaproteobacteria,3JQQG@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S hydrolases or acyltransferases, alpha beta hydrolase superfamily - - - - - - - - - - - - Abhydrolase_6,DUF1100,Peptidase_S9 k59_35113_1 1318628.MARLIPOL_07379 6.09e-28 114.0 COG0058@1|root,COG0058@2|Bacteria,1MW4J@1224|Proteobacteria,1RN8P@1236|Gammaproteobacteria,464XN@72275|Alteromonadaceae 1236|Gammaproteobacteria G Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties glgP - 2.4.1.1 ko:K00688 ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931 - R02111 - ko00000,ko00001,ko01000 - GT35 - DUF3417,Phosphorylase k59_35118_1 1000565.METUNv1_03063 6.93e-39 141.0 COG0223@1|root,COG0223@2|Bacteria,1MU4Q@1224|Proteobacteria,2VIS2@28216|Betaproteobacteria,2KVNV@206389|Rhodocyclales 206389|Rhodocyclales J Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus fmt - 2.1.2.9 ko:K00604 ko00670,ko00970,map00670,map00970 - R03940 RC00026,RC00165 ko00000,ko00001,ko01000 - - - Formyl_trans_C,Formyl_trans_N k59_1504425_1 317025.Tcr_1987 2.81e-70 234.0 COG1198@1|root,COG1198@2|Bacteria,1MUUZ@1224|Proteobacteria,1RPZ7@1236|Gammaproteobacteria,4600P@72273|Thiotrichales 72273|Thiotrichales L Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA priA - - ko:K04066 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,Helicase_C,ResIII k59_1561649_1 436308.Nmar_1087 6.3e-08 60.1 arCOG08812@1|root,arCOG08812@2157|Archaea 436308.Nmar_1087|- - - - - - - - - - - - - - - - k59_1104373_1 1120963.KB894502_gene1356 1.26e-112 364.0 COG0840@1|root,COG2202@1|root,COG0840@2|Bacteria,COG2202@2|Bacteria,1MU9B@1224|Proteobacteria,1RMH0@1236|Gammaproteobacteria,2PZZT@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria T COG2202 FOG PAS PAC domain mcpA - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - Cache_3-Cache_2,HAMP,MCPsignal,PAS_3,PAS_4,PAS_8,PAS_9 k59_822742_1 390235.PputW619_0846 3.66e-105 319.0 COG4962@1|root,COG4962@2|Bacteria,1R7EN@1224|Proteobacteria,1RP9G@1236|Gammaproteobacteria,1YXTQ@136845|Pseudomonas putida group 1236|Gammaproteobacteria U secretion system protein E tadA - - ko:K02283 - - - - ko00000,ko02035,ko02044 - - - T2SSE k59_1561653_1 1088721.NSU_0380 1.9e-96 303.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2TQS3@28211|Alphaproteobacteria,2K07A@204457|Sphingomonadales 204457|Sphingomonadales T signal transduction protein containing a membrane domain, an EAL and a GGDEF domain - - - - - - - - - - - - EAL,GGDEF,PAS_4 k59_712682_1 402880.MmarC5_1266 2.24e-20 104.0 arCOG02636@1|root,arCOG02636@2157|Archaea 2157|Archaea - - - - 2.1.1.72 ko:K07317 - - - - ko00000,ko01000,ko02048 - - - Eco57I,MTS,N6_Mtase,TaqI_C k59_1442850_1 1121948.AUAC01000004_gene49 7.32e-12 65.1 COG0730@1|root,COG0730@2|Bacteria,1MVY3@1224|Proteobacteria,2TU6M@28211|Alphaproteobacteria,43ZSE@69657|Hyphomonadaceae 28211|Alphaproteobacteria S Sulfite exporter TauE/SafE - - - ko:K07090 - - - - ko00000 - - - TauE k59_1442850_2 314287.GB2207_09226 1.46e-34 119.0 COG1278@1|root,COG1278@2|Bacteria,1N6Q5@1224|Proteobacteria,1SCA7@1236|Gammaproteobacteria 1236|Gammaproteobacteria K Cold shock cspA - - ko:K03704 - - - - ko00000,ko03000 - - - CSD k59_1391377_1 436308.Nmar_0404 2.61e-77 238.0 COG1422@1|root,arCOG02673@2157|Archaea,41SNR@651137|Thaumarchaeota 651137|Thaumarchaeota U membrane - - - - - - - - - - - - DUF106 k59_764514_1 1217712.F971_02058 1.04e-32 119.0 COG0603@1|root,COG0603@2|Bacteria,1MU5V@1224|Proteobacteria,1RMG9@1236|Gammaproteobacteria,3NKQJ@468|Moraxellaceae 1236|Gammaproteobacteria F Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) queC - 6.3.4.20 ko:K06920 ko00790,ko01100,map00790,map01100 - R09978 RC00959 ko00000,ko00001,ko01000,ko03016 - - - QueC k59_764514_2 472759.Nhal_3160 0.000153 41.2 COG0369@1|root,COG0369@2|Bacteria 2|Bacteria C hydroxylamine reductase activity petH GO:0005575,GO:0005622,GO:0005623,GO:0009579,GO:0016020,GO:0034357,GO:0042651,GO:0044424,GO:0044436,GO:0044464 1.14.13.208,1.18.1.2,1.19.1.1 ko:K00528,ko:K02287,ko:K02641,ko:K15511 ko00195,ko00196,ko00362,ko01100,map00195,map00196,map00362,map01100 - R09555,R10159 RC01739 ko00000,ko00001,ko00194,ko01000 - - iJN678.petH CpcD,FAD_binding_6,Fer4,NAD_binding_1 k59_202400_1 1125863.JAFN01000001_gene1350 5.46e-82 258.0 COG0043@1|root,COG0043@2|Bacteria,1MU62@1224|Proteobacteria,42N7V@68525|delta/epsilon subdivisions,2WJWF@28221|Deltaproteobacteria 28221|Deltaproteobacteria H 3-octaprenyl-4-hydroxybenzoate carboxy-lyase - - 4.1.1.98 ko:K03182 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00117 R04985,R04986 RC00391 ko00000,ko00001,ko00002,ko01000 - - - UbiD k59_1727878_1 85643.Tmz1t_1462 6.01e-06 47.4 arCOG10317@1|root,2Z7VW@2|Bacteria,1RGUS@1224|Proteobacteria,2VYXP@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_1727878_2 1174528.JH992892_gene6418 3.37e-222 635.0 COG3119@1|root,COG3119@2|Bacteria,1G3QV@1117|Cyanobacteria 1117|Cyanobacteria P COG3119 Arylsulfatase A and related enzymes - - 3.1.6.1 ko:K01130 ko00140,ko00600,map00140,map00600 - R03980,R04856 RC00128,RC00231 ko00000,ko00001,ko01000 - - - Sulfatase k59_35143_1 1318628.MARLIPOL_03360 1.15e-30 119.0 COG1651@1|root,COG1651@2|Bacteria,1MX2T@1224|Proteobacteria,1SASV@1236|Gammaproteobacteria 1236|Gammaproteobacteria O COG1651 Protein-disulfide isomerase - - - - - - - - - - - - Thioredoxin_4 k59_1051813_1 436308.Nmar_0290 5.54e-145 417.0 COG3875@1|root,arCOG02046@2157|Archaea,41SK4@651137|Thaumarchaeota 651137|Thaumarchaeota S Domain of unknown function (DUF2088) - - - - - - - - - - - - - k59_1051813_2 436308.Nmar_0291 9.18e-26 103.0 COG0750@1|root,arCOG00609@2157|Archaea,41S8V@651137|Thaumarchaeota 651137|Thaumarchaeota M Peptidase family M50 - - - - - - - - - - - - Peptidase_M50 k59_202402_1 1411685.U062_00280 2.84e-81 253.0 COG2265@1|root,COG2265@2|Bacteria,1MY45@1224|Proteobacteria,1RN2B@1236|Gammaproteobacteria,1J4SP@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Dual-specificity methyltransferase that catalyzes the formation of 5-methyluridine at position 54 (m5U54) in all tRNAs, and that of position 341 (m5U341) in tmRNA (transfer-mRNA) trmA GO:0000049,GO:0001510,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016300,GO:0016740,GO:0016741,GO:0019843,GO:0030488,GO:0030696,GO:0030697,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0140098,GO:0140101,GO:1901360,GO:1901363 2.1.1.35 ko:K00557 - - - - ko00000,ko01000,ko03016 - - - tRNA_U5-meth_tr k59_35150_1 5691.AAZ11720 1.28e-15 75.9 COG2084@1|root,KOG0409@2759|Eukaryota,3XS8U@5653|Kinetoplastida 5653|Kinetoplastida E 2-hydroxy-3-oxopropionate reductase - - 1.1.1.60 ko:K00042 ko00630,ko01100,map00630,map01100 - R01745,R01747 RC00099 ko00000,ko00001,ko01000 - - - NAD_binding_11,NAD_binding_2 k59_35150_2 1123284.KB899042_gene1333 1.48e-07 55.5 COG1284@1|root,COG1284@2|Bacteria,1TRBT@1239|Firmicutes,4HBPR@91061|Bacilli,26PBC@186821|Sporolactobacillaceae 91061|Bacilli S Uncharacterized protein conserved in bacteria (DUF2179) yitT - - - - - - - - - - - DUF2179,YitT_membrane k59_934524_1 203122.Sde_0505 6.26e-54 182.0 COG2942@1|root,COG2942@2|Bacteria,1R7VZ@1224|Proteobacteria,1RY4Y@1236|Gammaproteobacteria,466HS@72275|Alteromonadaceae 1236|Gammaproteobacteria G N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase) - - 5.3.1.8 ko:K01809 ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130 M00114 R01819 RC00376 ko00000,ko00001,ko00002,ko01000 - - - GlcNAc_2-epim k59_599604_1 1207063.P24_02201 7.34e-77 243.0 COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,2TRN7@28211|Alphaproteobacteria,2JQ3A@204441|Rhodospirillales 204441|Rhodospirillales C COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes lpd - 1.8.1.4 ko:K00382 ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00036,M00307,M00532 R00209,R01221,R01698,R03815,R07618,R08549 RC00004,RC00022,RC00583,RC02742,RC02833,RC02834 br01601,ko00000,ko00001,ko00002,ko01000,ko04147 - - - Biotin_lipoyl,Pyr_redox_2,Pyr_redox_dim k59_1051818_1 384765.SIAM614_22462 1.28e-109 325.0 COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,2TQTP@28211|Alphaproteobacteria 1224|Proteobacteria L Transposase ISPlu13C - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_1391399_1 402881.Plav_3577 3.2e-56 183.0 COG4094@1|root,COG4094@2|Bacteria,1RDHB@1224|Proteobacteria,2TQWY@28211|Alphaproteobacteria,1JP7J@119043|Rhodobiaceae 28211|Alphaproteobacteria S NnrU protein nnrU - - - - - - - - - - - NnrU k59_1504463_1 1283299.AUKG01000002_gene4199 8.65e-95 302.0 COG1138@1|root,COG1138@2|Bacteria,2HZM9@201174|Actinobacteria,4CRCE@84995|Rubrobacteria 84995|Rubrobacteria O Cytochrome c-type biogenesis protein CcmF C-terminal - - - ko:K02198 - - - - ko00000,ko02000 9.B.14.1 - - CcmF_C,Cytochrom_C_asm k59_202414_1 243159.AFE_1910 5.03e-79 248.0 COG0304@1|root,COG0304@2|Bacteria,1MU1X@1224|Proteobacteria,1RMDE@1236|Gammaproteobacteria,2NCB1@225057|Acidithiobacillales 225057|Acidithiobacillales I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP - - 2.3.1.179 ko:K09458 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119 RC00039,RC02728,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Ketoacyl-synt_C,ketoacyl-synt k59_1670077_1 1121878.AUGL01000026_gene1905 5.97e-31 125.0 COG3419@1|root,COG3419@2|Bacteria,1NUAV@1224|Proteobacteria,1RPV3@1236|Gammaproteobacteria 1236|Gammaproteobacteria NU Tfp pilus assembly protein tip-associated adhesin PilY1 comC - - ko:K02674 - - - - ko00000,ko02035,ko02044 - - - Neisseria_PilC,VWA_2 k59_1561697_1 1123393.KB891329_gene991 6.18e-99 298.0 COG1219@1|root,COG1219@2|Bacteria,1MVQK@1224|Proteobacteria,2VIEU@28216|Betaproteobacteria,1KRGT@119069|Hydrogenophilales 119069|Hydrogenophilales O ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP clpX - - ko:K03544 ko04112,map04112 - - - ko00000,ko00001,ko03110 - - - AAA_2,ClpB_D2-small,zf-C4_ClpX k59_1163083_1 1217718.ALOU01000002_gene4659 1.19e-14 74.3 COG0751@1|root,COG0751@2|Bacteria,1MV2F@1224|Proteobacteria,2VICG@28216|Betaproteobacteria,1K0KS@119060|Burkholderiaceae 28216|Betaproteobacteria J Glycyl-tRNA synthetase beta subunit glyS - 6.1.1.14 ko:K01879 ko00970,map00970 M00360 R03654 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DALR_1,tRNA_synt_2f k59_1163083_2 754476.Q7A_610 9.45e-12 66.2 COG0204@1|root,COG0204@2|Bacteria,1MY51@1224|Proteobacteria,1RQYC@1236|Gammaproteobacteria,460NX@72273|Thiotrichales 72273|Thiotrichales I Acyltransferase - - 2.3.1.51 ko:K00655 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R02241,R09381 RC00004,RC00037,RC00039 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Acyltransferase k59_1615316_1 745310.G432_01645 1.49e-30 124.0 COG1629@1|root,COG4771@2|Bacteria,1MWKN@1224|Proteobacteria,2U3JH@28211|Alphaproteobacteria,2K1GK@204457|Sphingomonadales 204457|Sphingomonadales P receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_1104413_1 751945.Theos_2002 1.41e-13 72.4 COG0441@1|root,COG0441@2|Bacteria,1WI8Y@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus J Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) thrS GO:0003674,GO:0003824,GO:0004812,GO:0004829,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006435,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.3 ko:K01868 ko00970,map00970 M00359,M00360 R03663 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,TGS,tRNA-synt_2b,tRNA_SAD k59_1391431_1 51511.ENSCSAVP00000007785 1.8e-60 202.0 COG1249@1|root,KOG0405@2759|Eukaryota,39J8D@33154|Opisthokonta,3BDB0@33208|Metazoa,3D06N@33213|Bilateria,482J2@7711|Chordata 33208|Metazoa Q glutathione-disulfide reductase activity GSR GO:0000003,GO:0000166,GO:0000302,GO:0000303,GO:0000305,GO:0002931,GO:0003674,GO:0003824,GO:0004362,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0005829,GO:0005886,GO:0006091,GO:0006139,GO:0006518,GO:0006575,GO:0006725,GO:0006749,GO:0006790,GO:0006807,GO:0006950,GO:0006979,GO:0007276,GO:0007283,GO:0007568,GO:0007584,GO:0008150,GO:0008152,GO:0009055,GO:0009605,GO:0009636,GO:0009897,GO:0009986,GO:0009987,GO:0009991,GO:0010033,GO:0010035,GO:0010038,GO:0010039,GO:0010041,GO:0014823,GO:0015036,GO:0015037,GO:0015038,GO:0015949,GO:0016020,GO:0016209,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0018996,GO:0019953,GO:0022404,GO:0022414,GO:0022900,GO:0031667,GO:0031974,GO:0032501,GO:0032502,GO:0032504,GO:0033189,GO:0033218,GO:0033273,GO:0033554,GO:0033993,GO:0034599,GO:0034641,GO:0035094,GO:0036094,GO:0042221,GO:0042277,GO:0042303,GO:0042395,GO:0042493,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043295,GO:0043603,GO:0044237,GO:0044238,GO:0044281,GO:0044422,GO:0044424,GO:0044425,GO:0044429,GO:0044444,GO:0044446,GO:0044459,GO:0044464,GO:0044703,GO:0045471,GO:0046483,GO:0046677,GO:0046686,GO:0046983,GO:0048037,GO:0048232,GO:0048609,GO:0050660,GO:0050661,GO:0050662,GO:0050896,GO:0051186,GO:0051704,GO:0051716,GO:0055086,GO:0055114,GO:0070013,GO:0070887,GO:0071704,GO:0071944,GO:0072341,GO:0097159,GO:0097237,GO:0097305,GO:0098552,GO:0098622,GO:0098754,GO:0098869,GO:1900750,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901681,GO:1901700,GO:1990748 1.8.1.7 ko:K00383 ko00480,ko04918,map00480,map04918 - R00094,R00115 RC00011 ko00000,ko00001,ko01000 - - - Pyr_redox_2,Pyr_redox_dim k59_652187_1 1415778.JQMM01000001_gene988 8.98e-116 350.0 COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,1RME8@1236|Gammaproteobacteria,1J4WR@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins ftsH GO:0000166,GO:0003674,GO:0003824,GO:0004175,GO:0004176,GO:0004222,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0008270,GO:0009056,GO:0009057,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030145,GO:0030163,GO:0030554,GO:0031224,GO:0031226,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043273,GO:0044238,GO:0044425,GO:0044459,GO:0044464,GO:0046872,GO:0046914,GO:0070011,GO:0071704,GO:0071944,GO:0097159,GO:0097367,GO:0098796,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575 - ko:K03798 - M00742 - - ko00000,ko00002,ko01000,ko01002,ko03110 - - - AAA,FtsH_ext,Peptidase_M41 k59_260131_1 1121948.AUAC01000002_gene1572 2.75e-25 100.0 COG4719@1|root,COG4719@2|Bacteria,1N09K@1224|Proteobacteria,2VGKU@28211|Alphaproteobacteria,440K6@69657|Hyphomonadaceae 28211|Alphaproteobacteria S TIGRFAM conserved repeat domain - - - - - - - - - - - - DUF11 k59_1329988_1 1122604.JONR01000004_gene772 1.73e-42 145.0 COG5517@1|root,COG5517@2|Bacteria,1RAFN@1224|Proteobacteria,1RR9V@1236|Gammaproteobacteria 1236|Gammaproteobacteria Q K COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit - - - - - - - - - - - - SnoaL_4 k59_990145_2 1522072.IL54_1138 2.82e-53 182.0 COG4770@1|root,COG4770@2|Bacteria,1P6RE@1224|Proteobacteria,2TRC2@28211|Alphaproteobacteria,2K27B@204457|Sphingomonadales 204457|Sphingomonadales I acetyl propionyl-CoA carboxylase, alpha subunit - - 6.4.1.4 ko:K01968 ko00280,ko01100,map00280,map01100 M00036 R04138 RC00367,RC00942 ko00000,ko00001,ko00002,ko01000 - - - Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2 k59_318301_1 1229909.NSED_07010 2.74e-36 138.0 COG3794@1|root,arCOG10350@1|root,arCOG02926@2157|Archaea,arCOG10350@2157|Archaea 2157|Archaea C sister chromatid segregation - - - - - - - - - - - - Copper-bind,Kazal_1 k59_1780287_1 1122137.AQXF01000004_gene1683 1.71e-63 205.0 COG0428@1|root,COG0428@2|Bacteria,1QZBY@1224|Proteobacteria 1224|Proteobacteria P Predicted permease - - - - - - - - - - - - ArsP_1 k59_35214_1 1122622.ATWJ01000001_gene2507 1.53e-64 221.0 COG2905@1|root,COG2905@2|Bacteria,2I91C@201174|Actinobacteria,4FEXU@85021|Intrasporangiaceae 201174|Actinobacteria T Putative nucleotidyltransferase DUF294 - - - ko:K07182 - - - - ko00000 - - - CBS,DUF294,DUF294_C,cNMP_binding k59_202464_1 1121935.AQXX01000143_gene4233 1.55e-54 185.0 COG0859@1|root,COG0859@2|Bacteria,1MYZA@1224|Proteobacteria,1RR6K@1236|Gammaproteobacteria,1XJE3@135619|Oceanospirillales 135619|Oceanospirillales M Glycosyl transferase family 9 opsX - - ko:K02849,ko:K12982 ko00540,ko01100,map00540,map01100 M00080 - - ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT9 - Glyco_transf_9 k59_1219910_1 1286631.X805_01930 7.95e-82 251.0 COG0289@1|root,COG0289@2|Bacteria,1MUCT@1224|Proteobacteria,2VJC3@28216|Betaproteobacteria,1KJ45@119065|unclassified Burkholderiales 28216|Betaproteobacteria E Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate dapB GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008839,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0019752,GO:0019877,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576 1.17.1.8 ko:K00215 ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R04198,R04199 RC00478 ko00000,ko00001,ko00002,ko01000 - - - DapB_C,DapB_N k59_1561751_1 1122962.AULH01000021_gene3661 1.05e-105 311.0 COG0450@1|root,COG0450@2|Bacteria,1MX2B@1224|Proteobacteria,2TT09@28211|Alphaproteobacteria,37097@31993|Methylocystaceae 28211|Alphaproteobacteria O Redoxin - - 1.11.1.15 ko:K03386 ko04214,map04214 - - - ko00000,ko00001,ko01000,ko04147 - - - 1-cysPrx_C,AhpC-TSA k59_1780298_1 1278309.KB907099_gene2796 7.73e-103 311.0 COG1115@1|root,COG1115@2|Bacteria,1MUI3@1224|Proteobacteria,1RMNF@1236|Gammaproteobacteria,1XHC5@135619|Oceanospirillales 135619|Oceanospirillales E alanine symporter dagA - - ko:K03310 - - - - ko00000 2.A.25 - - Na_Ala_symp k59_934590_1 1137799.GZ78_28565 1.05e-49 163.0 COG1943@1|root,COG1943@2|Bacteria,1MX19@1224|Proteobacteria,1RSJY@1236|Gammaproteobacteria,1XQ07@135619|Oceanospirillales 135619|Oceanospirillales L Transposase - - - - - - - - - - - - Y1_Tnp k59_944832_1 436308.Nmar_1492 7.85e-22 96.3 arCOG03272@1|root,arCOG03272@2157|Archaea 436308.Nmar_1492|- - - - - - - - - - - - - - - - k59_436585_1 316067.Geob_1952 4.22e-62 201.0 COG1071@1|root,COG1071@2|Bacteria,1MU5R@1224|Proteobacteria,42MHF@68525|delta/epsilon subdivisions,2WJ1R@28221|Deltaproteobacteria,43SF0@69541|Desulfuromonadales 28221|Deltaproteobacteria C The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) pdhA - 1.2.4.1 ko:K00161,ko:K21416 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230 M00307 R00014,R00209,R01699,R03270 RC00004,RC00027,RC00627,RC02742,RC02744,RC02882 br01601,ko00000,ko00001,ko00002,ko01000 - - - E1_dh k59_101216_2 436308.Nmar_1756 5.5e-48 155.0 COG1594@1|root,arCOG00579@2157|Archaea,41SS3@651137|Thaumarchaeota 651137|Thaumarchaeota K Belongs to the archaeal rpoM eukaryotic RPA12 RPB9 RPC11 RNA polymerase family - - - ko:K03057 ko01100,map01100 - - - br01611,ko00000,ko03021 - - - TFIIS_C k59_385476_1 641526.ADIWIN_2800 9.47e-46 157.0 COG1253@1|root,COG1253@2|Bacteria,4NE7C@976|Bacteroidetes,1HYD7@117743|Flavobacteriia 976|Bacteroidetes S COGs COG1253 Hemolysins and related protein containing CBS domains - - - - - - - - - - - - CBS,DUF21 k59_385476_2 1046627.BZARG_1709 1.79e-49 161.0 COG0350@1|root,COG0350@2|Bacteria,4NFYC@976|Bacteroidetes,1I29J@117743|Flavobacteriia 976|Bacteroidetes L Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated ogt - 2.1.1.63 ko:K00567,ko:K10778 - - - - ko00000,ko01000,ko03000,ko03400 - - - DNA_binding_1,Methyltransf_1N k59_1402640_1 1197477.IA57_02520 2.14e-77 250.0 COG1305@1|root,COG1305@2|Bacteria,4NE7G@976|Bacteroidetes,1HWP9@117743|Flavobacteriia 976|Bacteroidetes E Domain of Unknown Function with PDB structure (DUF3857) - - - - - - - - - - - - DUF3857,DUF3858,Transglut_core k59_1283591_1 861530.ALOZ01000049_gene2527 1.29e-17 83.6 COG1070@1|root,COG1070@2|Bacteria,1TP91@1239|Firmicutes,4HBGF@91061|Bacilli,4GYIG@90964|Staphylococcaceae 91061|Bacilli G FGGY family of carbohydrate kinases, N-terminal domain araB - 2.7.1.16 ko:K00853 ko00040,ko01100,map00040,map01100 - R01526,R02439 RC00002,RC00538 ko00000,ko00001,ko01000 - - - FGGY_C,FGGY_N k59_1000635_1 493475.GARC_1936 1.09e-58 197.0 COG2207@1|root,COG2207@2|Bacteria,1MX23@1224|Proteobacteria,1RRXM@1236|Gammaproteobacteria 1236|Gammaproteobacteria K AraC family transcriptional regulator oruR - - - - - - - - - - - Arabinose_bd,HTH_18 k59_723940_1 390235.PputW619_1616 3.63e-34 140.0 COG2199@1|root,COG3706@2|Bacteria,1RC1J@1224|Proteobacteria,1S2CD@1236|Gammaproteobacteria,1YXDR@136845|Pseudomonas putida group 1236|Gammaproteobacteria T Diguanylate cyclase with PAS PAC sensor - - - - - - - - - - - - CHASE,GGDEF,PAS,PAS_3,PAS_9 k59_1114604_1 525368.HMPREF0591_3111 7.94e-77 248.0 COG0318@1|root,COG0318@2|Bacteria,2GMVB@201174|Actinobacteria,236WM@1762|Mycobacteriaceae 201174|Actinobacteria IQ COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II - - - - - - - - - - - - AMP-binding,AMP-binding_C k59_1283616_1 1121897.AUGO01000008_gene2707 1.68e-09 60.5 COG0745@1|root,COG0745@2|Bacteria,4NQNT@976|Bacteroidetes,1I3AQ@117743|Flavobacteriia,2NWVA@237|Flavobacterium 976|Bacteroidetes KT cheY-homologous receiver domain - - - - - - - - - - - - Response_reg k59_1061885_1 1337936.IJ00_07990 1.02e-44 150.0 COG5113@1|root,COG3236@2|Bacteria 2|Bacteria O hydrolase activity, hydrolyzing N-glycosyl compounds - - - ko:K09935 - - - - ko00000 - - - DUF1768 k59_155873_1 313628.LNTAR_09736 3.12e-68 219.0 COG4099@1|root,COG4099@2|Bacteria 2|Bacteria F phospholipase Carboxylesterase - - - - - - - - - - - - Abhydrolase_2,Abhydrolase_8,DLH,Esterase,Peptidase_S9 k59_610551_1 1122137.AQXF01000003_gene2485 2.21e-42 149.0 COG0677@1|root,COG0677@2|Bacteria,1MUC6@1224|Proteobacteria,2TR5F@28211|Alphaproteobacteria 28211|Alphaproteobacteria M Belongs to the UDP-glucose GDP-mannose dehydrogenase family wecC - 1.1.1.336 ko:K02472 ko00520,ko05111,map00520,map05111 - R03317 RC00291 ko00000,ko00001,ko01000 - - - UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N k59_610551_2 1122137.AQXF01000003_gene2486 2.84e-66 212.0 COG0381@1|root,COG0381@2|Bacteria,1MWZN@1224|Proteobacteria,2TTGZ@28211|Alphaproteobacteria 28211|Alphaproteobacteria M Belongs to the UDP-N-acetylglucosamine 2-epimerase family wecB - 5.1.3.14 ko:K01791 ko00520,ko01100,ko05111,map00520,map01100,map05111 M00362 R00420 RC00290 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Epimerase_2 k59_662885_2 345073.VC395_0242 2.9e-81 250.0 COG0689@1|root,COG0689@2|Bacteria,1MVFZ@1224|Proteobacteria,1RNTB@1236|Gammaproteobacteria,1XU74@135623|Vibrionales 135623|Vibrionales J Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates rph GO:0003674,GO:0003824,GO:0004518,GO:0004540,GO:0006139,GO:0006396,GO:0006399,GO:0006401,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016075,GO:0016787,GO:0016788,GO:0019439,GO:0034470,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0140098,GO:1901360,GO:1901361,GO:1901575 2.7.7.56 ko:K00989 - - - - ko00000,ko01000,ko03016 - - - RNase_PH,RNase_PH_C k59_1000660_1 1120953.AUBH01000004_gene3151 3.67e-115 343.0 COG0388@1|root,COG0388@2|Bacteria,1MX4I@1224|Proteobacteria,1RP30@1236|Gammaproteobacteria,4648Q@72275|Alteromonadaceae 1236|Gammaproteobacteria K COG0454 Histone acetyltransferase HPA2 and related acetyltransferases yhcX - - - - - - - - - - - Acetyltransf_1,CN_hydrolase k59_328923_1 552811.Dehly_0707 8.24e-24 110.0 COG0493@1|root,COG1148@1|root,COG0493@2|Bacteria,COG1148@2|Bacteria,2G6SR@200795|Chloroflexi,34CV6@301297|Dehalococcoidia 200795|Chloroflexi C Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster - - 1.4.1.13,1.4.1.14,1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 ko:K00266,ko:K03388 ko00250,ko00680,ko00910,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00250,map00680,map00910,map01100,map01110,map01120,map01130,map01200,map01230 M00356,M00357,M00563,M00567 R00093,R00114,R00248,R04540,R11928,R11931,R11943,R11944 RC00006,RC00010,RC00011,RC02799 ko00000,ko00001,ko00002,ko01000 - - - Fer4_20,Pyr_redox_2 k59_1790055_1 158500.BV97_02412 6.35e-28 109.0 COG2084@1|root,COG2084@2|Bacteria,1MUGU@1224|Proteobacteria,2TT50@28211|Alphaproteobacteria,2K0B1@204457|Sphingomonadales 204457|Sphingomonadales I COG2084 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases - - 1.1.1.31 ko:K00020 ko00280,ko01100,map00280,map01100 - R05066 RC00099 ko00000,ko00001,ko01000 - - - NAD_binding_11,NAD_binding_2 k59_1790055_2 1174684.EBMC1_00135 1.13e-07 54.7 COG1171@1|root,COG1171@2|Bacteria,1MVWJ@1224|Proteobacteria,2TQN9@28211|Alphaproteobacteria,2K130@204457|Sphingomonadales 204457|Sphingomonadales E Threonine dehydratase ilvA - 4.3.1.19 ko:K01754 ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230 M00570 R00220,R00996 RC00418,RC02600 ko00000,ko00001,ko00002,ko01000 - - - ACT,PALP k59_1737578_1 88036.EFJ26969 3.51e-11 68.9 KOG2615@1|root,KOG2615@2759|Eukaryota,37P1M@33090|Viridiplantae,3GGHM@35493|Streptophyta 35493|Streptophyta J Protein ZINC INDUCED - - - - - - - - - - - - MFS_1 k59_723970_1 1523503.JPMY01000022_gene3368 2.28e-94 283.0 2BVTQ@1|root,2Z7J9@2|Bacteria,1P01Z@1224|Proteobacteria,1RNNB@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Protein of unknown function (DUF2797) LA2027 - - - - - - - - - - - DUF2797 k59_662891_1 985762.SAGN_06229 2.48e-11 65.9 COG0085@1|root,COG0085@2|Bacteria,1TP96@1239|Firmicutes,4H9PK@91061|Bacilli,4GXQI@90964|Staphylococcaceae 91061|Bacilli K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoB GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234 2.7.7.6 ko:K03043 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7 k59_1173494_1 1144310.PMI07_001133 3.44e-75 239.0 COG2159@1|root,COG2159@2|Bacteria,1R5PG@1224|Proteobacteria,2U2G9@28211|Alphaproteobacteria,4BG3R@82115|Rhizobiaceae 28211|Alphaproteobacteria S Amidohydrolase - - 4.1.1.45 ko:K03392 ko00380,ko01100,map00380,map01100 M00038 R04323 RC00779 ko00000,ko00001,ko00002,ko01000 - - - Amidohydro_2 k59_547804_2 650150.ERH_0952 6.9e-17 83.6 COG1160@1|root,COG1160@2|Bacteria,1TPNM@1239|Firmicutes,3VNXS@526524|Erysipelotrichia 526524|Erysipelotrichia S GTPase that plays an essential role in the late steps of ribosome biogenesis der - - ko:K03977 - - - - ko00000,ko03009 - - - KH_dom-like,MMR_HSR1 k59_833359_1 1121403.AUCV01000061_gene3736 2.72e-54 192.0 COG1529@1|root,COG2080@1|root,COG1529@2|Bacteria,COG2080@2|Bacteria,1MUEA@1224|Proteobacteria,42MER@68525|delta/epsilon subdivisions,2WIYV@28221|Deltaproteobacteria,2MJFX@213118|Desulfobacterales 28221|Deltaproteobacteria C Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain coxL - 1.17.1.4,1.2.99.7 ko:K00087,ko:K07469 ko00230,ko01100,ko01120,map00230,map01100,map01120 M00546 R01768,R02103 RC00143 ko00000,ko00001,ko00002,ko01000 - - - Ald_Xan_dh_C,Ald_Xan_dh_C2,Fer2,Fer2_2 k59_1402694_1 1122137.AQXF01000004_gene1852 1.77e-31 120.0 COG2890@1|root,COG2890@2|Bacteria,1MXCQ@1224|Proteobacteria,2TZFK@28211|Alphaproteobacteria 28211|Alphaproteobacteria J Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif prmC GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006479,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0016740,GO:0016741,GO:0018364,GO:0019538,GO:0032259,GO:0036009,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0140096,GO:1901564 2.1.1.297 ko:K02493 - - R10806 RC00003,RC03279 ko00000,ko01000,ko03012 - - - MTS,Methyltransf_31 k59_1402694_2 1082931.KKY_2896 1.1e-38 139.0 COG0216@1|root,COG0216@2|Bacteria,1MV28@1224|Proteobacteria,2TQSV@28211|Alphaproteobacteria,3N6BP@45401|Hyphomicrobiaceae 28211|Alphaproteobacteria J Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA prfA - - ko:K02835 - - - - ko00000,ko03012 - - - PCRF,RF-1 k59_270853_1 1238182.C882_0948 2.74e-12 65.9 COG0508@1|root,COG0508@2|Bacteria,1MUGY@1224|Proteobacteria,2TRXM@28211|Alphaproteobacteria,2JPJK@204441|Rhodospirillales 204441|Rhodospirillales C The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) pdhC - 2.3.1.12 ko:K00627 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200 M00307 R00209,R02569 RC00004,RC02742,RC02857 br01601,ko00000,ko00001,ko00002,ko01000 - - - 2-oxoacid_dh,Biotin_lipoyl,E3_binding k59_270853_2 1122137.AQXF01000002_gene169 4.09e-77 243.0 COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,2TR8H@28211|Alphaproteobacteria 28211|Alphaproteobacteria C COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes lpd GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 1.8.1.4 ko:K00382 ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00036,M00307,M00532 R00209,R01221,R01698,R03815,R07618,R08549 RC00004,RC00022,RC00583,RC02742,RC02833,RC02834 br01601,ko00000,ko00001,ko00002,ko01000,ko04147 - - - Pyr_redox_2,Pyr_redox_dim k59_1229464_1 768706.Desor_1833 3.14e-09 63.9 COG1835@1|root,COG1835@2|Bacteria,1V7CG@1239|Firmicutes,24WKR@186801|Clostridia,263B9@186807|Peptococcaceae 186801|Clostridia I Acyltransferase family - - - - - - - - - - - - Acyl_transf_3 k59_385573_1 926550.CLDAP_19070 1.19e-68 217.0 COG3253@1|root,COG3253@2|Bacteria 2|Bacteria S peroxidase activity ywfI - - ko:K00435 ko00860,ko01100,ko01110,map00860,map01100,map01110 - R11522 RC00884 ko00000,ko00001,ko01000 - - - Chlor_dismutase k59_894126_1 436308.Nmar_0491 5.77e-159 452.0 COG0181@1|root,arCOG04299@2157|Archaea,41S6Z@651137|Thaumarchaeota 651137|Thaumarchaeota H Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps hemC - 2.5.1.61 ko:K01749 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R00084 RC02317 ko00000,ko00001,ko00002,ko01000 - - - Porphobil_deam,Porphobil_deamC k59_1737616_1 396588.Tgr7_0944 1.46e-80 249.0 COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,1RMAQ@1236|Gammaproteobacteria,1WXTC@135613|Chromatiales 135613|Chromatiales L transposase IS116 IS110 IS902 family - - - ko:K07486 - - - - ko00000 - - - DEDD_Tnp_IS110,Transposase_20 k59_436664_1 1229909.NSED_04960 9.25e-77 233.0 arCOG10557@1|root,arCOG10557@2157|Archaea,41T1I@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_833376_1 1122137.AQXF01000001_gene3385 1.15e-96 300.0 COG5360@1|root,COG5360@2|Bacteria,1MUJ4@1224|Proteobacteria,2TR5G@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Heparinase II III family protein MA20_25080 - - - - - - - - - - - Hepar_II_III k59_1680379_1 1117315.AHCA01000017_gene1589 7.34e-116 353.0 COG1028@1|root,COG3347@1|root,COG1028@2|Bacteria,COG3347@2|Bacteria,1MWSB@1224|Proteobacteria,1RNTD@1236|Gammaproteobacteria 1236|Gammaproteobacteria IQ Class II Aldolase and Adducin N-terminal domain - - - - - - - - - - - - Aldolase_II,adh_short_C2 k59_894134_1 1049564.TevJSym_as00240 3.57e-54 186.0 COG0815@1|root,COG0815@2|Bacteria,1MUBU@1224|Proteobacteria,1RM8M@1236|Gammaproteobacteria,1J4WW@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Transfers the fatty acyl group on membrane lipoproteins lnt GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016021,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019538,GO:0031224,GO:0031226,GO:0034645,GO:0036211,GO:0042157,GO:0042158,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576 - ko:K03820 - - - - ko00000,ko01000 - GT2 iEcSMS35_1347.EcSMS35_0678,iSbBS512_1146.SbBS512_E0590 CN_hydrolase k59_1339964_1 768671.ThimaDRAFT_0867 3.99e-90 274.0 COG0767@1|root,COG0767@2|Bacteria,1MVPN@1224|Proteobacteria,1S0WJ@1236|Gammaproteobacteria,1WWFB@135613|Chromatiales 135613|Chromatiales Q Permease MlaE - - - ko:K02066 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - MlaE,STAS_2 k59_724008_1 1120949.KB903311_gene758 0.000148 48.9 COG1309@1|root,COG1309@2|Bacteria,2HMZF@201174|Actinobacteria,4DECJ@85008|Micromonosporales 201174|Actinobacteria K Transcriptional regulator - - - - - - - - - - - - TetR_N,WHG k59_270889_1 1392490.JHZX01000001_gene3220 6.04e-39 134.0 COG0450@1|root,COG0450@2|Bacteria,4NEZZ@976|Bacteroidetes,1I036@117743|Flavobacteriia 976|Bacteroidetes O PFAM C-terminal domain of 1-Cys peroxiredoxin - - 1.11.1.15 ko:K03386 ko04214,map04214 - - - ko00000,ko00001,ko01000,ko04147 - - - 1-cysPrx_C,AhpC-TSA k59_270889_2 1046627.BZARG_2539 7.92e-73 223.0 COG0693@1|root,COG0693@2|Bacteria,4NQI1@976|Bacteroidetes,1HX4U@117743|Flavobacteriia 976|Bacteroidetes S Intracellular protease, PfpI family - - 3.5.1.124 ko:K05520 - - - - ko00000,ko01000,ko01002 - - - DJ-1_PfpI k59_1453509_1 984892.SPSE_1537 5.48e-48 168.0 COG0164@1|root,COG0164@2|Bacteria,1V1D6@1239|Firmicutes,4HB7M@91061|Bacilli,4GXD1@90964|Staphylococcaceae 91061|Bacilli L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids rnhB GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006281,GO:0006298,GO:0006401,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0032299,GO:0032991,GO:0033554,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576 3.1.26.4 ko:K03470 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - RNase_HII k59_1625286_1 1229909.NSED_00845 1.78e-17 81.6 COG0681@1|root,arCOG01739@2157|Archaea,41SQ2@651137|Thaumarchaeota 651137|Thaumarchaeota U Signal peptidase - - 3.4.21.89 ko:K13280 ko03060,map03060 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_S24 k59_1339977_2 1469245.JFBG01000037_gene1849 6.51e-33 127.0 COG3276@1|root,COG3276@2|Bacteria,1MWXH@1224|Proteobacteria,1RQJI@1236|Gammaproteobacteria 1236|Gammaproteobacteria J Translation elongation factor selB GO:0000049,GO:0000166,GO:0001514,GO:0001882,GO:0001883,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006412,GO:0006414,GO:0006417,GO:0006451,GO:0006518,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009069,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010608,GO:0016259,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019003,GO:0019222,GO:0019538,GO:0019752,GO:0031323,GO:0031326,GO:0032268,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034248,GO:0034641,GO:0034645,GO:0035368,GO:0035639,GO:0036094,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051246,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:2000112 - ko:K03833 - - - - ko00000,ko03012 - - - GTP_EFTU,GTP_EFTU_D2,SelB-wing_2,SelB-wing_3 k59_662937_1 1453503.AU05_21150 1.57e-21 96.3 COG0536@1|root,COG0536@2|Bacteria,1MUGZ@1224|Proteobacteria,1RMFQ@1236|Gammaproteobacteria 1236|Gammaproteobacteria S An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control obg GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006996,GO:0007059,GO:0008150,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019003,GO:0022607,GO:0022611,GO:0022613,GO:0022618,GO:0032502,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034622,GO:0035639,GO:0036094,GO:0042254,GO:0042255,GO:0043021,GO:0043023,GO:0043167,GO:0043168,GO:0043933,GO:0044085,GO:0044087,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0065003,GO:0065007,GO:0070925,GO:0071826,GO:0071840,GO:0090069,GO:0090071,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - ko:K03979 - - - - ko00000,ko01000,ko03009 - - - GTP1_OBG,MMR_HSR1 k59_662937_2 1149133.ppKF707_0229 5.2e-22 94.7 COG0263@1|root,COG0263@2|Bacteria,1MUBG@1224|Proteobacteria,1RM7X@1236|Gammaproteobacteria,1YF5B@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria E Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate proB GO:0000287,GO:0003674,GO:0003824,GO:0004349,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016597,GO:0016740,GO:0016772,GO:0016774,GO:0017144,GO:0018130,GO:0019202,GO:0019752,GO:0031406,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046872,GO:0055129,GO:0071704,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1901973 2.7.2.11 ko:K00931 ko00330,ko00332,ko01100,ko01130,ko01230,map00330,map00332,map01100,map01130,map01230 M00015 R00239 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase,PUA k59_610600_1 1379701.JPJC01000120_gene2105 2.84e-08 62.4 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,2TQR7@28211|Alphaproteobacteria,2K0BV@204457|Sphingomonadales 204457|Sphingomonadales NT methyl-accepting chemotaxis protein - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - HAMP,MCPsignal,dCache_1 k59_1515149_1 290397.Adeh_3846 6.18e-131 386.0 COG0312@1|root,COG0312@2|Bacteria,1MUSK@1224|Proteobacteria,42Y66@68525|delta/epsilon subdivisions,2WU83@28221|Deltaproteobacteria,2YX71@29|Myxococcales 28221|Deltaproteobacteria S Putative modulator of DNA gyrase - - - ko:K03568 - - - - ko00000,ko01002 - - - PmbA_TldD k59_1515149_2 411479.BACUNI_00222 1.5e-10 65.1 COG0312@1|root,COG0312@2|Bacteria,4NE1F@976|Bacteroidetes,2FPXY@200643|Bacteroidia,4AMRA@815|Bacteroidaceae 976|Bacteroidetes S Psort location Cytoplasmic, score 9.26 tldD3 - - ko:K03592 - - - - ko00000,ko01002 - - - PmbA_TldD k59_774547_1 1492738.FEM21_20960 1.19e-93 303.0 COG3408@1|root,COG3408@2|Bacteria,4NE1I@976|Bacteroidetes,1HY0D@117743|Flavobacteriia,2NUYK@237|Flavobacterium 976|Bacteroidetes G Domain of unknown function (DUF4450) - - - - - - - - - - - - Bac_rhamnosid6H,DUF4450,DUF608 k59_611353_1 1122137.AQXF01000005_gene1256 4.86e-17 79.3 COG0730@1|root,COG0730@2|Bacteria,1NAFA@1224|Proteobacteria 1224|Proteobacteria S membrane transporter protein - - - ko:K07090 - - - - ko00000 - - - TauE k59_611353_2 1122137.AQXF01000005_gene1255 0.0 1006.0 COG3653@1|root,COG3653@2|Bacteria,1MWWY@1224|Proteobacteria,2TSZZ@28211|Alphaproteobacteria 28211|Alphaproteobacteria Q COG3653 N-acyl-D-aspartate D-glutamate deacylase MA20_22865 - - - - - - - - - - - Amidohydro_3 k59_1340682_1 1168065.DOK_15074 3.39e-72 233.0 COG1012@1|root,COG1012@2|Bacteria,1MVGW@1224|Proteobacteria,1RN53@1236|Gammaproteobacteria,1J4US@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Belongs to the aldehyde dehydrogenase family calB - 1.2.1.68 ko:K00154 - - - - ko00000,ko01000 - - - Aldedh k59_1230099_1 1150469.RSPPHO_01492 2.17e-11 68.9 COG0500@1|root,COG2226@2|Bacteria,1PA5F@1224|Proteobacteria,2TRFS@28211|Alphaproteobacteria,2JQFF@204441|Rhodospirillales 204441|Rhodospirillales Q Methyltransferase domain - - - - - - - - - - - - Methyltransf_11,Methyltransf_23 k59_213661_1 435908.IDSA_03870 2.77e-84 260.0 COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,1RMM4@1236|Gammaproteobacteria,2QG7H@267893|Idiomarinaceae 1236|Gammaproteobacteria V AAA domain, putative AbiEii toxin, Type IV TA system ybhF - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_492845_1 1096930.L284_05985 5.79e-34 134.0 COG2199@1|root,COG3447@1|root,COG3447@2|Bacteria,COG3706@2|Bacteria,1RD8D@1224|Proteobacteria,2U0TB@28211|Alphaproteobacteria,2K2KT@204457|Sphingomonadales 204457|Sphingomonadales T MASE1 - - - - - - - - - - - - GGDEF,MASE1,PAS_3 k59_548323_1 316407.85675924 2.31e-123 362.0 COG2271@1|root,COG2271@2|Bacteria,1MVPS@1224|Proteobacteria,1RNMV@1236|Gammaproteobacteria,3XNY3@561|Escherichia 1236|Gammaproteobacteria P galactarate transporter garP GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0015711,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0044425,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944 - ko:K03535,ko:K08194,ko:K12299 - - - - ko00000,ko02000 2.A.1.14.1,2.A.1.14.14,2.A.1.14.7 - iECO103_1326.ECO103_4467,iSF_1195.SF3164,iSFxv_1172.SFxv_3474,iSSON_1240.SSON_2946,iS_1188.S3379 MFS_1 k59_1790777_1 765914.ThisiDRAFT_1083 6.92e-68 210.0 COG0233@1|root,COG0233@2|Bacteria,1N66T@1224|Proteobacteria,1RN75@1236|Gammaproteobacteria,1WY5S@135613|Chromatiales 135613|Chromatiales J Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another frr - - ko:K02838 - - - - ko00000,ko03012 - - - RRF k59_1790777_2 1196028.ALEF01000006_gene3254 1.14e-09 58.2 COG0020@1|root,COG0020@2|Bacteria,1TQTS@1239|Firmicutes,4HA37@91061|Bacilli,4C511@84406|Virgibacillus 91061|Bacilli I Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids uppS GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006066,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0071704,GO:1901576,GO:1901615,GO:1901617 2.5.1.31 ko:K00806 ko00900,ko01110,map00900,map01110 - R06447 RC00279,RC02839 ko00000,ko00001,ko01000,ko01006 - - - Prenyltransf k59_156400_1 1122137.AQXF01000007_gene3543 1.79e-160 465.0 COG0471@1|root,COG0471@2|Bacteria,1MUSA@1224|Proteobacteria,2TU0C@28211|Alphaproteobacteria 28211|Alphaproteobacteria P COG0471 Di- and tricarboxylate transporters - - - ko:K03319,ko:K09477,ko:K11106,ko:K14445 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.47,2.A.47.1,2.A.47.3.2,2.A.47.3.3 - - Na_sulph_symp k59_492847_2 436308.Nmar_1604 1.36e-101 303.0 COG0704@1|root,arCOG00318@2157|Archaea,41SC5@651137|Thaumarchaeota 651137|Thaumarchaeota K Phosphate uptake regulator - - - - - - - - - - - - MazE_antitoxin,PhoU k59_1625941_1 436308.Nmar_1743 9.52e-43 145.0 arCOG10601@1|root,arCOG10601@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_1625941_2 1229909.NSED_09275 1.85e-28 102.0 arCOG11612@1|root,arCOG11612@2157|Archaea,41T8D@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1515726_1 702113.PP1Y_Mpl5313 3.62e-82 249.0 COG2375@1|root,COG2375@2|Bacteria,1R4TD@1224|Proteobacteria,2U6TC@28211|Alphaproteobacteria,2K4AS@204457|Sphingomonadales 204457|Sphingomonadales P Siderophore-interacting protein - - - - - - - - - - - - FAD_binding_9,SIP k59_386265_1 926566.Terro_1937 8.98e-32 130.0 COG2374@1|root,COG2374@2|Bacteria,3Y6CB@57723|Acidobacteria,2JMEK@204432|Acidobacteriia 204432|Acidobacteriia S Endonuclease Exonuclease Phosphatase - - - - - - - - - - - - - k59_101956_1 685035.ADAE01000023_gene1731 4.28e-106 323.0 COG4653@1|root,COG4653@2|Bacteria,1MWU1@1224|Proteobacteria,2TSSY@28211|Alphaproteobacteria,2K0P2@204457|Sphingomonadales 204457|Sphingomonadales S phage phi-C31 gp36 major capsid-like protein - - - - - - - - - - - - Phage_capsid k59_834095_1 702113.PP1Y_AT20553 1.79e-41 141.0 COG0047@1|root,COG0047@2|Bacteria,1MU4Y@1224|Proteobacteria,2TS67@28211|Alphaproteobacteria,2K0NC@204457|Sphingomonadales 204457|Sphingomonadales F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL purQ - 6.3.5.3 ko:K01952 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04463 RC00010,RC01160 ko00000,ko00001,ko00002,ko01000 - - - GATase_5 k59_834095_3 983920.Y88_2652 6.45e-14 70.1 COG1028@1|root,COG1028@2|Bacteria,1MXNQ@1224|Proteobacteria,2TS6G@28211|Alphaproteobacteria,2K07N@204457|Sphingomonadales 204457|Sphingomonadales IQ Belongs to the short-chain dehydrogenases reductases (SDR) family - - - - - - - - - - - - adh_short k59_213675_1 331869.BAL199_11191 6.77e-32 127.0 COG0443@1|root,COG0443@2|Bacteria,1MVEN@1224|Proteobacteria,2TR5H@28211|Alphaproteobacteria,4BPSN@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria O Heat shock 70 kDa protein dnaK - - ko:K04043 ko03018,ko04212,ko05152,map03018,map04212,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 1.A.33.1 - - HSP70 k59_156402_1 1170562.Cal6303_5180 5.85e-43 155.0 COG2843@1|root,COG2843@2|Bacteria,1G0W8@1117|Cyanobacteria,1HJIW@1161|Nostocales 1117|Cyanobacteria M PFAM Bacterial capsule synthesis protein PGA_cap - - - ko:K07282 - - - - ko00000 - - - PGA_cap k59_894769_1 870187.Thini_3645 9.04e-99 300.0 COG0065@1|root,COG0065@2|Bacteria,1MVYR@1224|Proteobacteria,1RMF6@1236|Gammaproteobacteria,4601D@72273|Thiotrichales 72273|Thiotrichales E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate leuC - 4.2.1.33,4.2.1.35 ko:K01703 ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230 M00432,M00535 R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170 RC00497,RC00976,RC00977,RC01041,RC01046,RC03072 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase k59_945469_1 1128912.GMES_4077 2.1e-29 120.0 COG3746@1|root,COG3750@1|root,COG3746@2|Bacteria,COG3750@2|Bacteria,1RA39@1224|Proteobacteria,1RYTV@1236|Gammaproteobacteria,469GJ@72275|Alteromonadaceae 1236|Gammaproteobacteria P Phosphate-selective porin O and P - - - ko:K07221 - - - - ko00000,ko02000 1.B.5.1 - - Porin_O_P k59_1625944_1 1229909.NSED_09600 1.21e-158 454.0 COG0112@1|root,arCOG00070@2157|Archaea,41S7U@651137|Thaumarchaeota 651137|Thaumarchaeota E Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism glyA - 2.1.2.1 ko:K00600 ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523 M00140,M00141,M00346,M00532 R00945,R09099 RC00022,RC00112,RC01583,RC02958 ko00000,ko00001,ko00002,ko01000 - - - SHMT k59_213679_1 416348.Hlac_1335 6.99e-66 226.0 COG5013@1|root,arCOG01497@2157|Archaea,2XTNG@28890|Euryarchaeota,23TXI@183963|Halobacteria 183963|Halobacteria C Nitrate reductase alpha subunit narG - - ko:K17050 - - - - ko00000,ko02000 5.A.3.8 - - Molybdopterin,Molydop_binding k59_437225_1 1116472.MGMO_70c00130 5.98e-06 53.1 COG4773@1|root,COG4773@2|Bacteria,1QTT0@1224|Proteobacteria,1RNBT@1236|Gammaproteobacteria,1XEVS@135618|Methylococcales 135618|Methylococcales P TIGRFAM TonB-dependent siderophore receptor - - - - - - - - - - - - Plug,STN,TonB_dep_Rec k59_101969_1 671143.DAMO_0479 8.02e-28 114.0 COG3437@1|root,COG3437@2|Bacteria,2NPBP@2323|unclassified Bacteria 2|Bacteria T HD domain - - - ko:K07814 - - - - ko00000,ko02022 - - - HD,HD_5,Response_reg k59_338010_2 1417296.U879_00355 4.29e-09 58.9 28JTG@1|root,2Z7PY@2|Bacteria,1QVNY@1224|Proteobacteria,2U7ED@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Protein of unknown function (DUF2793) - - - - - - - - - - - - DUF2793 k59_338010_3 648757.Rvan_3322 5.17e-122 371.0 28MJ5@1|root,2ZAVR@2|Bacteria,1R5CR@1224|Proteobacteria,2UAIJ@28211|Alphaproteobacteria,3N8IV@45401|Hyphomicrobiaceae 28211|Alphaproteobacteria - - - - - - - - - - - - - - Phage_stabilise k59_1182681_1 765912.Thimo_1062 1.21e-85 277.0 COG0342@1|root,COG0342@2|Bacteria,1MV5U@1224|Proteobacteria,1RMIQ@1236|Gammaproteobacteria,1WX1G@135613|Chromatiales 135613|Chromatiales U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA secD - - ko:K03072 ko03060,ko03070,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 2.A.6.4,3.A.5.2,3.A.5.7 - - SecD-TM1,SecD_SecF,Sec_GG k59_222251_1 247634.GPB2148_3570 5.4e-79 249.0 COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,1RMFF@1236|Gammaproteobacteria,1J50Z@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes lpdG GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 1.8.1.4 ko:K00382 ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00036,M00307,M00532 R00209,R01221,R01698,R03815,R07618,R08549 RC00004,RC00022,RC00583,RC02742,RC02833,RC02834 br01601,ko00000,ko00001,ko00002,ko01000,ko04147 - - iE2348C_1286.E2348C_4372,iJN746.PP_4187 Pyr_redox_2,Pyr_redox_dim k59_445984_1 1122137.AQXF01000001_gene3224 6.03e-92 278.0 COG1420@1|root,COG1420@2|Bacteria,1MVX4@1224|Proteobacteria,2TRUF@28211|Alphaproteobacteria 28211|Alphaproteobacteria K Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons hrcA - - ko:K03705 - - - - ko00000,ko03000 - - - HrcA,HrcA_DNA-bdg k59_445984_2 1122137.AQXF01000001_gene3223 3.01e-70 218.0 COG0576@1|root,COG0576@2|Bacteria,1RH8T@1224|Proteobacteria,2U5V2@28211|Alphaproteobacteria 28211|Alphaproteobacteria O Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ grpE - - ko:K03687 - - - - ko00000,ko03029,ko03110 - - - GrpE k59_903333_1 555500.I215_10435 2.98e-06 48.5 COG0665@1|root,COG0665@2|Bacteria,4NEUE@976|Bacteroidetes,1HYMG@117743|Flavobacteriia 976|Bacteroidetes E Glycine D-amino acid dadA - 1.4.5.1 ko:K00285 ko00360,map00360 - R01374,R09493 RC00006,RC00025 ko00000,ko00001,ko01000 - - - DAO k59_903333_2 999550.KI421507_gene367 8.79e-59 192.0 COG3938@1|root,COG3938@2|Bacteria,1NVF9@1224|Proteobacteria,2TX8Z@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Belongs to the proline racemase family - GO:0003674,GO:0003824,GO:0016853,GO:0016854,GO:0016855,GO:0036361,GO:0047580,GO:0047661 5.1.1.4,5.1.1.8 ko:K01777,ko:K12658 ko00330,ko01100,map00330,map01100 - R01255,R03296 RC00479 ko00000,ko00001,ko01000 - - - Pro_racemase k59_280375_1 1123270.ATUR01000006_gene157 1.77e-87 266.0 COG1960@1|root,COG1960@2|Bacteria,1REWC@1224|Proteobacteria,2U8I5@28211|Alphaproteobacteria,2K2J2@204457|Sphingomonadales 204457|Sphingomonadales I Acyl-CoA dehydrogenase, C-terminal domain - - - - - - - - - - - - Acyl-CoA_dh_1 k59_783526_1 1365176.N186_06845 2.6e-08 60.5 COG0554@1|root,arCOG00024@2157|Archaea,2XPZQ@28889|Crenarchaeota 28889|Crenarchaeota F Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate glpK GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615 2.7.1.30 ko:K00864 ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626 - R00847 RC00002,RC00017 ko00000,ko00001,ko01000,ko04147 - - - FGGY_C,FGGY_N k59_1123913_1 566466.NOR53_585 1.06e-15 81.6 COG5616@1|root,COG5616@2|Bacteria,1NSKC@1224|Proteobacteria,1S0KQ@1236|Gammaproteobacteria,1J82F@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S cAMP biosynthetic process - - - - - - - - - - - - - k59_110761_1 745718.JADT01000001_gene1742 4.45e-28 108.0 COG1272@1|root,COG1272@2|Bacteria,4NM95@976|Bacteroidetes,1HYZQ@117743|Flavobacteriia 976|Bacteroidetes S membrane protein, hemolysin III homolog hly-III - - ko:K11068 - - - - ko00000,ko02042 - - - HlyIII k59_783529_1 1229909.NSED_03865 2.35e-40 147.0 arCOG08796@1|root,arCOG08796@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_1462981_1 1198452.Jab_1c17710 1.06e-26 105.0 COG0755@1|root,COG0755@2|Bacteria,1MU61@1224|Proteobacteria,2VHF8@28216|Betaproteobacteria 28216|Betaproteobacteria U Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes ccmC - - ko:K02195 ko02010,map02010 M00259 - - ko00000,ko00001,ko00002,ko02000 3.A.1.107 - - Cytochrom_C_asm k59_1462981_2 323848.Nmul_A1216 9.28e-22 90.9 COG2386@1|root,COG2386@2|Bacteria,1NJB0@1224|Proteobacteria,2VNPU@28216|Betaproteobacteria,371Q1@32003|Nitrosomonadales 28216|Betaproteobacteria U Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes ccmB - - ko:K02194 ko02010,map02010 M00259 - - ko00000,ko00001,ko00002,ko02000 3.A.1.107 - - CcmB k59_843210_1 710421.Mycch_3007 5.37e-13 68.9 COG4221@1|root,COG4221@2|Bacteria,2GP05@201174|Actinobacteria,233G0@1762|Mycobacteriaceae 201174|Actinobacteria S Belongs to the short-chain dehydrogenases reductases (SDR) family cad - - - - - - - - - - - adh_short k59_843210_2 998674.ATTE01000001_gene3420 4.56e-05 46.2 COG1309@1|root,COG1309@2|Bacteria,1N6HV@1224|Proteobacteria,1SBC8@1236|Gammaproteobacteria 1236|Gammaproteobacteria K COG1309 Transcriptional regulator - - - - - - - - - - - - TetR_C_2,TetR_C_6,TetR_N k59_733371_1 393595.ABO_1787 1.08e-26 100.0 COG2963@1|root,COG2963@2|Bacteria,1N1CG@1224|Proteobacteria,1SAIC@1236|Gammaproteobacteria,1XPKX@135619|Oceanospirillales 135619|Oceanospirillales L Transposase - - - ko:K07483 - - - - ko00000 - - - HTH_Tnp_1 k59_733371_2 926692.AZYG01000085_gene856 5.88e-82 258.0 COG2801@1|root,COG2801@2|Bacteria,1TU21@1239|Firmicutes,249HN@186801|Clostridia,3WA8E@53433|Halanaerobiales 186801|Clostridia L Integrase catalytic region - - - ko:K07497 - - - - ko00000 - - - HTH_21,rve k59_1581848_2 861299.J421_2655 6.94e-40 142.0 COG0825@1|root,COG0825@2|Bacteria,1ZSW6@142182|Gemmatimonadetes 142182|Gemmatimonadetes I Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA accA - 2.1.3.15,6.4.1.2 ko:K01962 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04386 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 - - - ACCA k59_280396_1 1122137.AQXF01000001_gene2579 1.51e-56 204.0 COG2931@1|root,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,2U7AB@28211|Alphaproteobacteria 28211|Alphaproteobacteria MQ Haemolysin-type calcium-binding repeat (2 copies) - - - - - - - - - - - - HemolysinCabind k59_1123914_1 1415778.JQMM01000001_gene705 2.56e-83 269.0 COG0744@1|root,COG0744@2|Bacteria,1QTST@1224|Proteobacteria,1RNHV@1236|Gammaproteobacteria,1J4N3@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits) mrcB - 2.4.1.129,3.4.16.4 ko:K05365 ko00550,map00550 - R04519 RC00005,RC00049 ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 - Transgly,Transpeptidase,UB2H k59_1123914_2 1415778.JQMM01000001_gene706 1.16e-22 95.5 COG0457@1|root,COG0457@2|Bacteria,1PGU5@1224|Proteobacteria,1S3ND@1236|Gammaproteobacteria,1JBDC@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Tetratricopeptide repeat - - - - - - - - - - - - - k59_1412085_2 862751.SACTE_6479 1.91e-29 114.0 COG1028@1|root,COG1028@2|Bacteria,2GM3I@201174|Actinobacteria 201174|Actinobacteria IQ Short-chain dehydrogenase reductase sdr - - - - - - - - - - - - adh_short,adh_short_C2 k59_1123924_1 883126.HMPREF9710_05181 8.61e-42 154.0 COG0457@1|root,COG0457@2|Bacteria,1N0A9@1224|Proteobacteria,2VKEE@28216|Betaproteobacteria 28216|Betaproteobacteria S COG0457 FOG TPR repeat - - - - - - - - - - - - TPR_14 k59_338040_1 1415778.JQMM01000001_gene2244 9.03e-54 191.0 COG1196@1|root,COG4656@1|root,COG1196@2|Bacteria,COG4656@2|Bacteria,1QTUI@1224|Proteobacteria,1RMIM@1236|Gammaproteobacteria,1J4YP@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Part of a membrane complex involved in electron transport rnfC GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0055114 - ko:K03615 - - - - ko00000 - - - Complex1_51K,Fer4_10,Fer4_7,Fer4_8,RnfC_N,SLBB k59_1799257_1 1288484.APCS01000056_gene2827 1.43e-11 71.2 COG3850@1|root,COG5002@1|root,COG3850@2|Bacteria,COG5002@2|Bacteria,1WNDZ@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - HAMP,HATPase_c,HisKA k59_954194_1 384765.SIAM614_04290 5.16e-49 175.0 COG0072@1|root,COG0073@1|root,COG0072@2|Bacteria,COG0073@2|Bacteria,1MWKS@1224|Proteobacteria,2TQV8@28211|Alphaproteobacteria 28211|Alphaproteobacteria J Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily pheT GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016070,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494 6.1.1.20 ko:K01890 ko00970,map00970 M00359,M00360 R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - B3_4,B5,FDX-ACB,tRNA_bind k59_954194_2 1122137.AQXF01000004_gene1410 6.48e-184 518.0 COG2230@1|root,COG2230@2|Bacteria,1RJ4C@1224|Proteobacteria,2UA2C@28211|Alphaproteobacteria 28211|Alphaproteobacteria M cyclopropane-fatty-acyl-phospholipid synthase - - - - - - - - - - - - CMAS,Methyltransf_23,Methyltransf_31 k59_954194_3 1122137.AQXF01000004_gene1411 1.42e-198 567.0 COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,2TRKS@28211|Alphaproteobacteria 28211|Alphaproteobacteria I Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA acsA - 6.2.1.1,6.2.1.16 ko:K01895,ko:K01907 ko00010,ko00280,ko00620,ko00640,ko00650,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00280,map00620,map00640,map00650,map00680,map00720,map01100,map01110,map01120,map01130,map01200 M00357 R00235,R00236,R00316,R00926,R01354,R01357 RC00004,RC00012,RC00014,RC00043,RC00070,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000,ko01004 - - - ACAS_N,AMP-binding,AMP-binding_C k59_783554_1 1122137.AQXF01000006_gene685 1.28e-48 159.0 COG1580@1|root,COG1580@2|Bacteria,1RH5D@1224|Proteobacteria,2U9BF@28211|Alphaproteobacteria 28211|Alphaproteobacteria N Controls the rotational direction of flagella during chemotaxis fliL - - ko:K02415 - - - - ko00000,ko02035 - - - FliL k59_783554_2 1122137.AQXF01000006_gene684 9.34e-13 69.3 COG1868@1|root,COG1868@2|Bacteria,1MX01@1224|Proteobacteria,2TR4F@28211|Alphaproteobacteria 28211|Alphaproteobacteria N FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation fliM - - ko:K02416 ko02030,ko02040,map02030,map02040 - - - ko00000,ko00001,ko02035 - - - FliM,FliMN_C k59_1182716_1 1282360.ABAC460_22420 7.98e-62 209.0 COG0657@1|root,COG4677@1|root,COG0657@2|Bacteria,COG4677@2|Bacteria,1QBYN@1224|Proteobacteria,2U34J@28211|Alphaproteobacteria,2KINJ@204458|Caulobacterales 204458|Caulobacterales G Pectinesterase - - 3.1.1.11 ko:K01051 ko00040,ko01100,map00040,map01100 M00081 R02362 RC00460,RC00461 ko00000,ko00001,ko00002,ko01000 - - - Abhydrolase_3,Pectinesterase k59_110813_1 580332.Slit_2576 2.09e-105 316.0 COG0172@1|root,COG0172@2|Bacteria,1MUJF@1224|Proteobacteria,2VHJJ@28216|Betaproteobacteria,44V1U@713636|Nitrosomonadales 28216|Betaproteobacteria J Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) serS - 6.1.1.11 ko:K01875 ko00970,map00970 M00359,M00360 R03662,R08218 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Seryl_tRNA_N,tRNA-synt_2b k59_673037_1 1205680.CAKO01000037_gene1375 2.82e-05 46.2 COG0696@1|root,COG0696@2|Bacteria,1MUQ1@1224|Proteobacteria,2TS6R@28211|Alphaproteobacteria,2JR4Y@204441|Rhodospirillales 204441|Rhodospirillales G Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate gpmI - 5.4.2.12 ko:K15633 ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003 R01518 RC00536 ko00000,ko00001,ko00002,ko01000 - - - Metalloenzyme,Phosphodiest,iPGM_N k59_673037_2 1304878.AUGD01000003_gene2355 1.03e-05 51.6 COG4942@1|root,COG4942@2|Bacteria,1MY3E@1224|Proteobacteria,2TUSP@28211|Alphaproteobacteria,3JT1N@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria D Peptidase family M23 filA - - - - - - - - - - - Peptidase_M23 k59_784484_1 1122137.AQXF01000005_gene1209 1.17e-101 310.0 COG0659@1|root,COG0659@2|Bacteria,1MXA7@1224|Proteobacteria,2TV6Y@28211|Alphaproteobacteria 28211|Alphaproteobacteria P secondary active sulfate transmembrane transporter activity MA20_17540 - - ko:K06901 - - - - ko00000,ko02000 2.A.1.40 - - - k59_1239472_1 1088721.NSU_4226 2.49e-23 94.7 COG0149@1|root,COG0149@2|Bacteria,1MWK5@1224|Proteobacteria,2TS6I@28211|Alphaproteobacteria,2K1PI@204457|Sphingomonadales 204457|Sphingomonadales G Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) tpiA - 5.3.1.1 ko:K01803 ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003 R01015 RC00423 ko00000,ko00001,ko00002,ko01000,ko04147 - - - TIM k59_55794_2 436308.Nmar_0369 7.53e-40 141.0 COG1063@1|root,arCOG01459@2157|Archaea 2157|Archaea C Catalyzes the NAD(P)( )-dependent oxidation of D-glucose to D-gluconate via gluconolactone. Can utilize both NAD( ) and NADP( ) as electron acceptor. Is involved in the degradation of glucose through a - - 1.1.1.1 ko:K00001 ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220 - R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310 RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273 ko00000,ko00001,ko01000 - - - ADH_N,ADH_zinc_N,Glu_dehyd_C k59_1525307_2 1210045.ALNP01000014_gene2811 1.82e-22 98.6 COG1132@1|root,COG1132@2|Bacteria,2GITR@201174|Actinobacteria 201174|Actinobacteria V ABC transporter - - - ko:K06147 - - - - ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran k59_621419_1 983545.Glaag_1037 3.81e-71 221.0 COG0704@1|root,COG0704@2|Bacteria,1MUMI@1224|Proteobacteria,1RMW5@1236|Gammaproteobacteria,466D2@72275|Alteromonadaceae 1236|Gammaproteobacteria P Plays a role in the regulation of phosphate uptake phoU GO:0000287,GO:0001558,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006873,GO:0006950,GO:0007154,GO:0008150,GO:0009266,GO:0009267,GO:0009268,GO:0009405,GO:0009408,GO:0009605,GO:0009628,GO:0009892,GO:0009987,GO:0009991,GO:0010468,GO:0010563,GO:0010605,GO:0010629,GO:0010966,GO:0016020,GO:0016036,GO:0019220,GO:0019222,GO:0019725,GO:0019897,GO:0019898,GO:0022898,GO:0030002,GO:0030145,GO:0030320,GO:0030643,GO:0031323,GO:0031324,GO:0031667,GO:0031668,GO:0031669,GO:0032409,GO:0032410,GO:0032412,GO:0032413,GO:0032879,GO:0033554,GO:0034605,GO:0034762,GO:0034763,GO:0034765,GO:0034766,GO:0040008,GO:0042221,GO:0042592,GO:0042594,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0043269,GO:0043271,GO:0044070,GO:0044092,GO:0044419,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0045936,GO:0046677,GO:0046872,GO:0046914,GO:0046983,GO:0048519,GO:0048523,GO:0048878,GO:0050789,GO:0050794,GO:0050801,GO:0050896,GO:0051049,GO:0051051,GO:0051128,GO:0051174,GO:0051704,GO:0051716,GO:0055062,GO:0055081,GO:0055082,GO:0055083,GO:0060255,GO:0065007,GO:0065008,GO:0065009,GO:0070887,GO:0071214,GO:0071236,GO:0071467,GO:0071496,GO:0071944,GO:0072501,GO:0072502,GO:0072505,GO:0072506,GO:0098771,GO:0104004,GO:1903792,GO:1903795,GO:1903796,GO:1903959,GO:1903960,GO:2000185,GO:2000186 - ko:K02039 - - - - ko00000 - - - PhoU k59_1350131_1 1123355.JHYO01000012_gene773 6.95e-13 64.7 COG0278@1|root,COG0278@2|Bacteria,1MZ4V@1224|Proteobacteria,2U9QB@28211|Alphaproteobacteria,36YMN@31993|Methylocystaceae 28211|Alphaproteobacteria O Glutaredoxin grxC2 - - ko:K07390 - - - - ko00000,ko03029,ko03110 - - - Glutaredoxin k59_1350131_2 1122137.AQXF01000002_gene548 3.45e-43 141.0 COG0271@1|root,COG0271@2|Bacteria,1R3MM@1224|Proteobacteria,2UBUW@28211|Alphaproteobacteria 28211|Alphaproteobacteria T Belongs to the BolA IbaG family MA20_09125 - - - - - - - - - - - BolA k59_1183600_1 1173022.Cri9333_1599 5.73e-37 145.0 COG0515@1|root,COG2203@1|root,COG3899@1|root,COG4191@1|root,COG0515@2|Bacteria,COG2203@2|Bacteria,COG3899@2|Bacteria,COG4191@2|Bacteria,1GBKM@1117|Cyanobacteria,1H7D9@1150|Oscillatoriales 1117|Cyanobacteria KLT Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - AAA_16,GAF,HATPase_c,HisKA,Pkinase k59_166119_1 436308.Nmar_0703 2.38e-44 152.0 COG0258@1|root,arCOG04050@2157|Archaea,41SBU@651137|Thaumarchaeota 651137|Thaumarchaeota L Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double- stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into fen - - ko:K04799 ko03030,ko03410,ko03450,map03030,map03410,map03450 - - - ko00000,ko00001,ko01000,ko03032,ko03400,ko04147 - - - XPG_I,XPG_N k59_1747768_1 316407.85674338 3.98e-134 397.0 COG3064@1|root,COG3064@2|Bacteria,1MXPS@1224|Proteobacteria,1RQIV@1236|Gammaproteobacteria,3XNHJ@561|Escherichia 1236|Gammaproteobacteria M Protein of unknown function (DUF3300) yacH - - - - - - - - - - - DUF3300 k59_223218_1 1123240.ATVO01000006_gene1534 1.28e-21 93.6 COG0145@1|root,COG0145@2|Bacteria,1MU2Y@1224|Proteobacteria,2TQZ6@28211|Alphaproteobacteria,2K20D@204457|Sphingomonadales 204457|Sphingomonadales EQ PFAM Hydantoinase oxoprolinase - - 3.5.2.14 ko:K01473 ko00330,ko01100,map00330,map01100 - R03187 RC00632 ko00000,ko00001,ko01000 - - - Hydant_A_N,Hydantoinase_A k59_223218_2 1248760.ANFZ01000018_gene517 4.95e-81 251.0 COG0119@1|root,COG0119@2|Bacteria,1MUMX@1224|Proteobacteria,2TT1R@28211|Alphaproteobacteria,2K1YI@204457|Sphingomonadales 204457|Sphingomonadales E HMGL-like - - 4.1.3.4 ko:K01640 ko00072,ko00280,ko00281,ko00650,ko01100,ko04146,map00072,map00280,map00281,map00650,map01100,map04146 M00036,M00088 R01360,R08090 RC00502,RC00503,RC01118,RC01946 ko00000,ko00001,ko00002,ko01000 - - - HMGL-like k59_1124811_1 378806.STAUR_3281 3.07e-06 54.7 COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,42Q67@68525|delta/epsilon subdivisions,2WKZ1@28221|Deltaproteobacteria,2YZQ7@29|Myxococcales 28221|Deltaproteobacteria KLT Phosphotransferase enzyme family - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase k59_1124816_1 644107.SL1157_0407 3.1e-14 68.6 COG2080@1|root,COG2080@2|Bacteria,1MWA6@1224|Proteobacteria,2TS73@28211|Alphaproteobacteria,4NDS8@97050|Ruegeria 28211|Alphaproteobacteria C [2Fe-2S] binding domain - - - - - - - - - - - - Fer2,Fer2_2 k59_1124816_2 247639.MGP2080_04095 1.74e-41 153.0 COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,1RN40@1236|Gammaproteobacteria,1J9VK@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C COG1529 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL CutL homologs yagR GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016903,GO:0030151,GO:0033554,GO:0042597,GO:0043167,GO:0043169,GO:0044464,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0055114 1.17.1.4 ko:K11177 ko00230,ko01100,ko01120,map00230,map01100,map01120 M00546 R01768,R02103 RC00143 ko00000,ko00001,ko00002,ko01000 - - - Ald_Xan_dh_C,Ald_Xan_dh_C2 k59_1690828_1 1122137.AQXF01000005_gene1200 3.32e-93 281.0 COG1079@1|root,COG1079@2|Bacteria,1MVDQ@1224|Proteobacteria,2TSTD@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Belongs to the binding-protein-dependent transport system permease family araH - - ko:K02057 - M00221 - - ko00000,ko00002,ko02000 3.A.1.2 - - BPD_transp_2 k59_1635553_1 497321.C664_11380 2.04e-09 58.5 COG0010@1|root,COG4992@1|root,COG0010@2|Bacteria,COG4992@2|Bacteria,1MV3C@1224|Proteobacteria,2VHEB@28216|Betaproteobacteria,2KWDX@206389|Rhodocyclales 206389|Rhodocyclales E COG0010 Arginase agmatinase formimionoglutamate hydrolase, arginase family rocD - 2.6.1.13 ko:K00819 ko00330,ko01100,ko01110,ko01130,map00330,map01100,map01110,map01130 - R00667 RC00006,RC00062 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_3,Arginase k59_1239517_1 1110502.TMO_2113 5.47e-85 272.0 COG1376@1|root,COG1376@2|Bacteria,1MVYT@1224|Proteobacteria,2TUXV@28211|Alphaproteobacteria,2JS3F@204441|Rhodospirillales 204441|Rhodospirillales S L,D-transpeptidase catalytic domain - - - ko:K16291 - - - - ko00000,ko01002,ko01011 - - - YkuD k59_734265_1 436308.Nmar_0291 5.35e-109 323.0 COG0750@1|root,arCOG00609@2157|Archaea,41S8V@651137|Thaumarchaeota 651137|Thaumarchaeota M Peptidase family M50 - - - - - - - - - - - - Peptidase_M50 k59_1800208_1 525904.Tter_0617 2.97e-43 158.0 COG2317@1|root,COG2317@2|Bacteria,2NQC7@2323|unclassified Bacteria 2|Bacteria E Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues ypwA - 3.4.17.19 ko:K01299,ko:K03281 - - - - ko00000,ko01000,ko01002 2.A.49 - - Peptidase_M32 k59_621455_1 653733.Selin_1920 8e-55 186.0 COG0845@1|root,COG0845@2|Bacteria 2|Bacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family macA - - ko:K13888 - M00709 - - ko00000,ko00002,ko02000 8.A.1 - - HlyD_D23 k59_1747785_1 1461577.CCMH01000046_gene869 4.85e-28 110.0 COG0732@1|root,COG0732@2|Bacteria,4NIPK@976|Bacteroidetes,1I56H@117743|Flavobacteriia 976|Bacteroidetes V Type I restriction modification DNA specificity domain - - - - - - - - - - - - Methylase_S k59_1747785_2 986075.CathTA2_0129 1.57e-81 258.0 COG0286@1|root,COG0286@2|Bacteria,1USEH@1239|Firmicutes,4HDU1@91061|Bacilli 91061|Bacilli V Type I restriction-modification system methyltransferase subunit() - - 2.1.1.72 ko:K03427 - - - - ko00000,ko01000,ko02048 - - - N6_Mtase k59_1747786_1 1121937.AUHJ01000005_gene2183 3.42e-07 50.4 COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MUT8@1224|Proteobacteria,1RN6R@1236|Gammaproteobacteria,469XN@72275|Alteromonadaceae 1236|Gammaproteobacteria G PEP-utilising enzyme, TIM barrel domain ppdK - 2.7.1.202,2.7.3.9,2.7.9.1,2.7.9.2 ko:K01006,ko:K01007,ko:K02768,ko:K08483,ko:K11183 ko00051,ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,ko02060,map00051,map00620,map00680,map00710,map00720,map01100,map01120,map01200,map02060 M00169,M00171,M00172,M00173,M00273,M00374 R00199,R00206,R03232 RC00002,RC00015,RC00017,RC03206 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.2.1,8.A.7 - - PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C,PPDK_N,PTS-HPr,PTS_EIIA_2 k59_844210_1 472759.Nhal_1647 1.17e-36 129.0 COG1278@1|root,COG1278@2|Bacteria,1QW5N@1224|Proteobacteria,1T3Z1@1236|Gammaproteobacteria 1236|Gammaproteobacteria K Sigma 54 modulation protein / S30EA ribosomal protein - - - - - - - - - - - - CSD,Ribosomal_S30AE k59_1800229_1 314287.GB2207_10858 4.45e-112 335.0 COG0165@1|root,COG0165@2|Bacteria,1MUTU@1224|Proteobacteria,1RMA3@1236|Gammaproteobacteria,1J4JZ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E argininosuccinate lyase argH GO:0003674,GO:0003824,GO:0004056,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016829,GO:0016840,GO:0016842,GO:0019752,GO:0042450,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.3.2.1 ko:K01755 ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230 M00029,M00844,M00845 R01086 RC00445,RC00447 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ASL_C2,Lyase_1 k59_1294254_1 1054213.HMPREF9946_04474 3.78e-55 187.0 COG0160@1|root,COG0160@2|Bacteria,1MWY6@1224|Proteobacteria,2TUDG@28211|Alphaproteobacteria,2JQQB@204441|Rhodospirillales 204441|Rhodospirillales E Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family - - 2.6.1.19,2.6.1.22 ko:K07250 ko00250,ko00280,ko00410,ko00640,ko00650,ko01100,ko01120,map00250,map00280,map00410,map00640,map00650,map01100,map01120 M00027 R00908,R01648,R04188 RC00006,RC00062,RC00160 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 k59_1294254_2 553207.HMPREF0299_5930 3.4e-15 76.6 COG2207@1|root,COG2207@2|Bacteria,2IARM@201174|Actinobacteria 201174|Actinobacteria K transcriptional regulator - - - - - - - - - - - - Arabinose_bd,HTH_18 k59_1072080_1 1337093.MBE-LCI_3778 9.67e-46 159.0 COG3328@1|root,COG3328@2|Bacteria,1MU4P@1224|Proteobacteria,2TTBD@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Transposase, Mutator family - - - - - - - - - - - - Transposase_mut k59_1800243_1 1229909.NSED_07570 1.14e-25 105.0 COG1498@1|root,arCOG01923@2157|Archaea,41SY9@651137|Thaumarchaeota 651137|Thaumarchaeota J NOSIC (NUC001) domain - - - ko:K14564 ko03008,map03008 - - - ko00000,ko00001,ko03009 - - - Nop k59_1800243_2 436308.Nmar_1390 7.08e-28 108.0 COG0167@1|root,arCOG00603@2157|Archaea 2157|Archaea F Catalyzes the conversion of dihydroorotate to orotate pyrD GO:0003674,GO:0003824,GO:0004152,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006206,GO:0006207,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009987,GO:0016491,GO:0016627,GO:0016635,GO:0018130,GO:0019856,GO:0034641,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046112,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 1.3.1.1,1.3.1.14,1.3.5.2,1.3.98.1 ko:K00226,ko:K00254,ko:K17723,ko:K17828 ko00240,ko00410,ko00770,ko01100,map00240,map00410,map00770,map01100 M00046,M00051 R00977,R01414,R01867,R01868,R01869,R11026 RC00051,RC00072,RC00123 ko00000,ko00001,ko00002,ko01000 - - - DHO_dh k59_1463982_1 401053.AciPR4_1305 2.23e-43 154.0 COG1660@1|root,COG1660@2|Bacteria,3Y2HM@57723|Acidobacteria,2JHJM@204432|Acidobacteriia 204432|Acidobacteriia S Displays ATPase and GTPase activities - - - ko:K06958 - - - - ko00000,ko03019 - - - ATP_bind_2 k59_844237_1 1458275.AZ34_17520 2.87e-30 115.0 COG4608@1|root,COG4608@2|Bacteria,1NU4K@1224|Proteobacteria,2W19X@28216|Betaproteobacteria,4ABCC@80864|Comamonadaceae 28216|Betaproteobacteria P Belongs to the ABC transporter superfamily - - - ko:K02032 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - ABC_tran,oligo_HPY k59_844237_2 1415779.JOMH01000001_gene485 5.92e-07 53.5 COG2982@1|root,COG2982@2|Bacteria,1NVUY@1224|Proteobacteria,1RPFM@1236|Gammaproteobacteria,1X3AR@135614|Xanthomonadales 135614|Xanthomonadales M AsmA family - - - - - - - - - - - - AsmA k59_1586193_1 1123269.NX02_09305 1.22e-59 202.0 COG0645@1|root,COG2187@1|root,COG0645@2|Bacteria,COG2187@2|Bacteria,1MU9M@1224|Proteobacteria,2TQJN@28211|Alphaproteobacteria,2K0MY@204457|Sphingomonadales 204457|Sphingomonadales S AAA domain - - - ko:K07028 - - - - ko00000 - - - AAA_33,APH k59_1755858_1 316407.4062537 4.63e-21 87.8 COG0670@1|root,COG0670@2|Bacteria,1MU69@1224|Proteobacteria,1RRVZ@1236|Gammaproteobacteria,3XNC8@561|Escherichia 1236|Gammaproteobacteria S Belongs to the BI1 family yccA GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0016021,GO:0019222,GO:0030162,GO:0031224,GO:0044425,GO:0044464,GO:0050789,GO:0051171,GO:0051246,GO:0060255,GO:0065007,GO:0071944,GO:0080090 - ko:K19416 - M00742 - - ko00000,ko00002,ko02000 1.A.14.2.1 - - Bax1-I k59_1755858_2 198214.SF0971 2.39e-73 220.0 COG2920@1|root,COG2920@2|Bacteria,1RGVG@1224|Proteobacteria,1S5ZA@1236|Gammaproteobacteria 1236|Gammaproteobacteria P part of a sulfur-relay system tusE GO:0002097,GO:0002098,GO:0002143,GO:0003674,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0034227,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0097163,GO:0140104,GO:1901360 - ko:K11179 ko04122,map04122 - - - ko00000,ko00001,ko01000,ko03016 - - - DsrC k59_1755858_3 199310.c1106 5.05e-17 74.7 COG1254@1|root,COG1254@2|Bacteria,1N6NU@1224|Proteobacteria,1SCPF@1236|Gammaproteobacteria,3XPZE@561|Escherichia 1236|Gammaproteobacteria C acylphosphatase activity acyP GO:0003674,GO:0003824,GO:0003998,GO:0006950,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0016787,GO:0016817,GO:0016818,GO:0050896 3.6.1.7 ko:K01512 ko00620,ko00627,ko01120,map00620,map00627,map01120 - R00317,R01421,R01515 RC00043 ko00000,ko00001,ko01000 - - iSBO_1134.SBO_2263,iSF_1195.SF0969,iSFxv_1172.SFxv_1053,iS_1188.S1036 Acylphosphatase k59_61391_1 262316.MAP_3512 4.13e-141 417.0 COG0028@1|root,COG0028@2|Bacteria,2GM6Y@201174|Actinobacteria,234PM@1762|Mycobacteriaceae 201174|Actinobacteria EH Belongs to the TPP enzyme family - - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_1191092_1 1122137.AQXF01000001_gene3186 2.16e-112 350.0 COG2844@1|root,COG2844@2|Bacteria,1MV54@1224|Proteobacteria,2TSV0@28211|Alphaproteobacteria 28211|Alphaproteobacteria O Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen glnD GO:0006355,GO:0006464,GO:0006807,GO:0006808,GO:0007154,GO:0007584,GO:0008150,GO:0008152,GO:0009605,GO:0009719,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0009991,GO:0010033,GO:0010243,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0018175,GO:0018177,GO:0019219,GO:0019222,GO:0019538,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031667,GO:0031668,GO:0031669,GO:0031670,GO:0036211,GO:0042221,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051716,GO:0060255,GO:0065007,GO:0070887,GO:0071310,GO:0071417,GO:0071495,GO:0071496,GO:0071704,GO:0080090,GO:0090293,GO:1901564,GO:1901698,GO:1901699,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141 2.7.7.59 ko:K00990 ko02020,map02020 - - - ko00000,ko00001,ko01000 - - - ACT,GlnD_UR_UTase,GlnE,HD,NTP_transf_2 k59_343831_1 502025.Hoch_5260 3.73e-07 53.9 COG1012@1|root,COG1012@2|Bacteria 2|Bacteria C belongs to the aldehyde dehydrogenase family luxC - 1.2.1.50 ko:K03400 ko02020,ko02024,map02020,map02024 - R10549 RC00004,RC00184 ko00000,ko00001,ko01000 - - - LuxC k59_343831_2 1027273.GZ77_13535 0.000408 42.4 COG0346@1|root,COG0346@2|Bacteria,1RJR7@1224|Proteobacteria,1S71Y@1236|Gammaproteobacteria 1236|Gammaproteobacteria E Lactoylglutathione lyase and related lyases - - - - - - - - - - - - Glyoxalase k59_1021947_1 757424.Hsero_2970 1.87e-117 348.0 COG0372@1|root,COG0372@2|Bacteria,1MUKX@1224|Proteobacteria,2VIJF@28216|Betaproteobacteria,472V7@75682|Oxalobacteraceae 28216|Betaproteobacteria H Belongs to the citrate synthase family gltA - 2.3.3.1 ko:K01647 ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00740 R00351 RC00004,RC00067 br01601,ko00000,ko00001,ko00002,ko01000 - - - Citrate_synt k59_1699386_1 1122137.AQXF01000002_gene603 6.69e-87 259.0 COG0461@1|root,COG0461@2|Bacteria,1RIC5@1224|Proteobacteria,2TUX2@28211|Alphaproteobacteria 28211|Alphaproteobacteria F Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) pyrE - 2.4.2.10 ko:K00762 ko00240,ko01100,map00240,map01100 M00051 R01870 RC00611 ko00000,ko00001,ko00002,ko01000 - - - Pribosyltran k59_625957_1 1122137.AQXF01000002_gene380 6.59e-140 423.0 COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,2TQK9@28211|Alphaproteobacteria 28211|Alphaproteobacteria L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate uvrA - - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - ABC_tran k59_964937_1 556268.OFAG_00818 2.54e-151 512.0 COG0553@1|root,COG0553@2|Bacteria 2|Bacteria L helicase activity - - - - - - - - - - - - Helicase_C,SNF2_N k59_852106_1 1027273.GZ77_25130 1.04e-54 187.0 COG0642@1|root,COG2205@2|Bacteria,1MUAK@1224|Proteobacteria,1RPP2@1236|Gammaproteobacteria,1XJ2S@135619|Oceanospirillales 135619|Oceanospirillales T Histidine kinase envZ - 2.7.13.3 ko:K07638 ko02020,ko02026,map02020,map02026 M00445,M00742,M00743 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,HisKA k59_343836_1 1265505.ATUG01000002_gene1234 5.28e-31 126.0 COG1196@1|root,COG1196@2|Bacteria,1MVMQ@1224|Proteobacteria,42NF4@68525|delta/epsilon subdivisions,2WIMP@28221|Deltaproteobacteria,2MJAB@213118|Desulfobacterales 28221|Deltaproteobacteria D nuclear chromosome segregation - - - - - - - - - - - - - k59_1021950_1 436308.Nmar_1008 7.66e-157 462.0 COG0458@1|root,COG0624@1|root,arCOG01107@2157|Archaea,arCOG01596@2157|Archaea 2157|Archaea EF ATP-grasp domain cxp2 - 3.4.17.11,3.5.1.18,6.3.2.4 ko:K01295,ko:K01439,ko:K01921,ko:K16181 ko00300,ko00473,ko00550,ko01100,ko01120,ko01230,ko01502,map00300,map00473,map00550,map01100,map01120,map01230,map01502 M00016 R01150,R02734,R10011 RC00064,RC00090,RC00096,RC00141 ko00000,ko00001,ko00002,ko01000,ko01002,ko01011 - - - ATP-grasp_3,CPSase_L_D2,Dala_Dala_lig_C,M20_dimer,Peptidase_M20 k59_569610_1 1415778.JQMM01000001_gene988 4.82e-114 344.0 COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,1RME8@1236|Gammaproteobacteria,1J4WR@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins ftsH GO:0000166,GO:0003674,GO:0003824,GO:0004175,GO:0004176,GO:0004222,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0008270,GO:0009056,GO:0009057,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030145,GO:0030163,GO:0030554,GO:0031224,GO:0031226,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043273,GO:0044238,GO:0044425,GO:0044459,GO:0044464,GO:0046872,GO:0046914,GO:0070011,GO:0071704,GO:0071944,GO:0097159,GO:0097367,GO:0098796,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575 - ko:K03798 - M00742 - - ko00000,ko00002,ko01000,ko01002,ko03110 - - - AAA,FtsH_ext,Peptidase_M41 k59_1416795_1 362418.IW19_01370 9.13e-05 50.1 COG1538@1|root,COG1538@2|Bacteria,4NDZ6@976|Bacteroidetes,1HY4E@117743|Flavobacteriia,2NSE6@237|Flavobacterium 976|Bacteroidetes MU outer membrane efflux protein - - - - - - - - - - - - OEP k59_1416795_2 998088.B565_3477 5e-14 67.8 COG0640@1|root,COG0640@2|Bacteria,1N72Q@1224|Proteobacteria,1SCH5@1236|Gammaproteobacteria,1Y5WU@135624|Aeromonadales 135624|Aeromonadales K helix_turn_helix, Arsenical Resistance Operon Repressor - - - ko:K22042 - - - - ko00000,ko03000 - - - HTH_5 k59_456581_1 1415778.JQMM01000001_gene556 1.08e-89 270.0 COG1192@1|root,COG1192@2|Bacteria,1MV43@1224|Proteobacteria,1RNJK@1236|Gammaproteobacteria,1J5A9@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria D ATPases involved in chromosome partitioning parA - - ko:K03496 - - - - ko00000,ko03036,ko04812 - - - AAA_31 k59_231747_1 1121104.AQXH01000001_gene1400 6.5e-22 98.6 COG0624@1|root,COG0624@2|Bacteria,4NEA7@976|Bacteroidetes,1IWTY@117747|Sphingobacteriia 976|Bacteroidetes E Peptidase dimerisation domain - - - - - - - - - - - - M20_dimer,Peptidase_M20 k59_627384_1 1044.EH31_07530 6.42e-88 280.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2TQS3@28211|Alphaproteobacteria,2K07A@204457|Sphingomonadales 204457|Sphingomonadales T signal transduction protein containing a membrane domain, an EAL and a GGDEF domain - - - - - - - - - - - - EAL,GGDEF,PAS_4 k59_345336_1 468059.AUHA01000002_gene563 3.43e-30 125.0 COG0457@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria,4NFW7@976|Bacteroidetes,1IR3J@117747|Sphingobacteriia 976|Bacteroidetes K Tetratricopeptide repeat - - - - - - - - - - - - ANAPC3,Guanylate_cyc,HTH_18,TPR_8 k59_797169_1 697284.ERIC2_c37820 4.96e-34 132.0 COG1624@1|root,COG1624@2|Bacteria,1TPRW@1239|Firmicutes,4H9XZ@91061|Bacilli,26R2I@186822|Paenibacillaceae 91061|Bacilli S Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria dacA GO:0003674,GO:0003824,GO:0004016,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0009975,GO:0016020,GO:0016021,GO:0016829,GO:0016849,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 2.7.7.85 ko:K18672 - - - - ko00000,ko01000 - - - DisA_N k59_1475042_1 1415778.JQMM01000001_gene1142 7.99e-30 119.0 28MBM@1|root,2ZAQ2@2|Bacteria,1R5V6@1224|Proteobacteria,1S0K0@1236|Gammaproteobacteria,1J5EM@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_1361883_1 436308.Nmar_1378 3.67e-24 97.1 COG1409@1|root,arCOG01153@2157|Archaea,41SF2@651137|Thaumarchaeota 651137|Thaumarchaeota S Calcineurin-like phosphoesterase superfamily domain - - - - - - - - - - - - Metallophos k59_1361883_2 436308.Nmar_1379 1.82e-55 182.0 COG0473@1|root,arCOG01163@2157|Archaea,41S5U@651137|Thaumarchaeota 651137|Thaumarchaeota C Isocitrate isopropylmalate dehydrogenase - - 1.1.1.42 ko:K00031 ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146 M00009,M00010,M00173,M00740 R00267,R00268,R01899 RC00001,RC00084,RC00114,RC00626,RC02801 br01601,ko00000,ko00001,ko00002,ko01000 - - - Iso_dh k59_1531501_1 1088721.NSU_1159 9.57e-30 110.0 2BNY5@1|root,32HN6@2|Bacteria,1NPJR@1224|Proteobacteria,2UMBD@28211|Alphaproteobacteria,2K80A@204457|Sphingomonadales 204457|Sphingomonadales - - - - - - - - - - - - - - - k59_1531501_2 702113.PP1Y_AT7336 1.07e-67 213.0 COG0031@1|root,COG0031@2|Bacteria,1MUBE@1224|Proteobacteria,2TR4W@28211|Alphaproteobacteria,2K0XR@204457|Sphingomonadales 204457|Sphingomonadales E Cysteine synthase - - 2.5.1.47 ko:K01738 ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230 M00021 R00897,R03601,R04859 RC00020,RC02814,RC02821 ko00000,ko00001,ko00002,ko01000 - - - PALP k59_1361897_1 1249627.D779_1220 4.18e-16 76.3 COG2823@1|root,COG2823@2|Bacteria,1MUZ2@1224|Proteobacteria,1RY2B@1236|Gammaproteobacteria,1WY1Q@135613|Chromatiales 135613|Chromatiales S PFAM transport-associated - - - - - - - - - - - - BON k59_1361897_2 1328313.DS2_14369 7.66e-07 51.6 COG1226@1|root,COG4651@1|root,COG1226@2|Bacteria,COG4651@2|Bacteria,1MV34@1224|Proteobacteria,1RNH4@1236|Gammaproteobacteria,464VC@72275|Alteromonadaceae 1236|Gammaproteobacteria P Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family ybaL - - ko:K03455 - - - - ko00000 2.A.37 - - Na_H_Exchanger,TrkA_N k59_853695_1 448385.sce5328 1.23e-111 341.0 COG0129@1|root,COG0129@2|Bacteria,1MUTQ@1224|Proteobacteria,42N3P@68525|delta/epsilon subdivisions,2WJB7@28221|Deltaproteobacteria,2YWT1@29|Myxococcales 28221|Deltaproteobacteria H Belongs to the IlvD Edd family ilvD - 4.2.1.9 ko:K01687 ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R01209,R04441,R05070 RC00468,RC01714 ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_1259 ILVD_EDD k59_853695_2 1118054.CAGW01000031_gene847 2.24e-07 54.3 COG0515@1|root,COG2815@1|root,COG0515@2|Bacteria,COG2815@2|Bacteria,1TP3F@1239|Firmicutes,4H9KD@91061|Bacilli,26TP2@186822|Paenibacillaceae 91061|Bacilli KLT serine threonine protein kinase prkC GO:0002237,GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005488,GO:0005539,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009605,GO:0009607,GO:0009617,GO:0009719,GO:0009847,GO:0009987,GO:0010033,GO:0010243,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019538,GO:0023052,GO:0032494,GO:0032502,GO:0036211,GO:0042221,GO:0042834,GO:0043170,GO:0043207,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051704,GO:0051707,GO:0051716,GO:0065007,GO:0070887,GO:0071216,GO:0071219,GO:0071224,GO:0071310,GO:0071417,GO:0071495,GO:0071704,GO:0071944,GO:0097367,GO:0140096,GO:1901564,GO:1901698,GO:1901699,GO:1901700,GO:1901701 2.7.11.1 ko:K08884,ko:K12132 - - - - ko00000,ko01000,ko01001 - - - PASTA,Pkinase k59_570717_1 543913.D521_1490 2.82e-59 186.0 COG3565@1|root,COG3565@2|Bacteria,1RD7C@1224|Proteobacteria,2VRG8@28216|Betaproteobacteria 28216|Betaproteobacteria S glyoxalase bleomycin resistance protein dioxygenase - - - ko:K06991 - - - - ko00000 - - - Glyoxalase k59_1475083_1 1229909.NSED_07415 8.3e-137 390.0 COG2159@1|root,arCOG01931@2157|Archaea 2157|Archaea S metal-dependent hydrolase of the TIM-barrel fold - - - ko:K07045 - - - - ko00000 - - - Amidohydro_2 k59_1475083_2 1229909.NSED_07420 1.36e-88 263.0 COG0456@1|root,arCOG00833@2157|Archaea 2157|Archaea C PFAM GCN5-related N-acetyltransferase - - 2.3.1.128 ko:K03789 - - - - ko00000,ko01000,ko03009 - - - Acetyltransf_1,Acetyltransf_10,Acetyltransf_7 k59_1644580_1 13690.CP98_00097 3.05e-104 320.0 COG1053@1|root,COG1053@2|Bacteria,1MURY@1224|Proteobacteria,2UQ4B@28211|Alphaproteobacteria,2KD4E@204457|Sphingomonadales 204457|Sphingomonadales C HI0933-like protein - - 1.3.99.4 ko:K05898 ko00984,ko01100,ko01120,map00984,map01100,map01120 - R09884 RC00991 ko00000,ko00001,ko01000 - - - FAD_binding_2 k59_1531558_1 153721.MYP_2418 1.66e-08 59.7 COG1127@1|root,COG1127@2|Bacteria,4NETJ@976|Bacteroidetes,47NIJ@768503|Cytophagia 976|Bacteroidetes Q ABC transporter - - - ko:K02065 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - ABC_tran k59_797230_1 1499967.BAYZ01000026_gene1569 1.13e-246 699.0 COG0443@1|root,COG0443@2|Bacteria,2NNU1@2323|unclassified Bacteria 2|Bacteria O Heat shock 70 kDa protein dnaK - - ko:K04043 ko03018,ko04212,ko05152,map03018,map04212,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 1.A.33.1 - - HSP70 k59_1475101_1 293826.Amet_4762 6.99e-12 70.5 COG0308@1|root,COG0308@2|Bacteria,1U6PC@1239|Firmicutes,24AYS@186801|Clostridia,36F7X@31979|Clostridiaceae 186801|Clostridia E PFAM Peptidase M1, membrane alanine - - - - - - - - - - - - Peptidase_M1 k59_570732_1 875328.JDM601_3502 0.000958 41.6 COG2128@1|root,COG2128@2|Bacteria,2IAT6@201174|Actinobacteria,238XY@1762|Mycobacteriaceae 201174|Actinobacteria S carboxymuconolactone decarboxylase - - - - - - - - - - - - CMD k59_1079206_1 696747.NIES39_J05200 6.17e-24 107.0 COG4122@1|root,COG4122@2|Bacteria,1GQYW@1117|Cyanobacteria,1HG6G@1150|Oscillatoriales 1117|Cyanobacteria S Sulfotransferase family - - - - - - - - - - - - Sulfotransfer_2 k59_175571_1 985665.HPL003_25715 1.05e-97 307.0 COG0495@1|root,COG0495@2|Bacteria,1TP0Y@1239|Firmicutes,4HAG1@91061|Bacilli,26QCH@186822|Paenibacillaceae 91061|Bacilli J Belongs to the class-I aminoacyl-tRNA synthetase family leuS GO:0003674,GO:0003824,GO:0004812,GO:0004823,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006429,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.4 ko:K01869 ko00970,map00970 M00359,M00360 R03657 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - Anticodon_1,tRNA-synt_1,tRNA-synt_1_2 k59_62977_1 675635.Psed_1447 4.73e-130 385.0 COG0138@1|root,COG0138@2|Bacteria,2I8U6@201174|Actinobacteria,4EAKX@85010|Pseudonocardiales 201174|Actinobacteria F AICARFT/IMPCHase bienzyme - - 2.1.2.3,3.5.4.10 ko:K00602 ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523 M00048 R01127,R04560 RC00026,RC00263,RC00456 ko00000,ko00001,ko00002,ko01000,ko04147 - - - AICARFT_IMPCHas k59_231800_1 69328.PVLB_08150 3.55e-41 149.0 2CCYB@1|root,2Z88J@2|Bacteria,1RA8X@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_740698_1 247639.MGP2080_01160 1.08e-45 161.0 COG1020@1|root,COG1020@2|Bacteria,1N7HY@1224|Proteobacteria,1RQJX@1236|Gammaproteobacteria 1236|Gammaproteobacteria Q Acyltransferase ws dgat mgat atfA1 - 2.3.1.20 ko:K00635 ko00561,ko01100,map00561,map01100 M00089 R02251 RC00004,RC00041 ko00000,ko00001,ko00002,ko01000 - - - DUF1298,WES_acyltransf k59_740698_2 83406.HDN1F_00750 2.29e-30 113.0 2DN4P@1|root,32VH9@2|Bacteria,1N2W8@1224|Proteobacteria,1SAXT@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Polyketide cyclase / dehydrase and lipid transport - - - - - - - - - - - - Polyketide_cyc2 k59_458016_1 1122149.BACN01000051_gene97 1.11e-24 102.0 COG1234@1|root,COG1234@2|Bacteria,1TRGP@1239|Firmicutes,4HABM@91061|Bacilli,3F4F1@33958|Lactobacillaceae 91061|Bacilli J Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA rnz GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0031123,GO:0034414,GO:0034470,GO:0034641,GO:0034660,GO:0042779,GO:0042780,GO:0042781,GO:0043170,GO:0043628,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1905267 3.1.26.11 ko:K00784 ko03013,map03013 - - - ko00000,ko00001,ko01000,ko03016 - - - Lactamase_B,Lactamase_B_2 k59_458016_2 1121289.JHVL01000013_gene1618 2.63e-12 66.6 COG0205@1|root,COG0205@2|Bacteria,1TPF4@1239|Firmicutes,248PB@186801|Clostridia,36DGA@31979|Clostridiaceae 186801|Clostridia F Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis pfkA - 2.7.1.11 ko:K00850 ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230 M00001,M00345 R00756,R03236,R03237,R03238,R03239,R04779 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000,ko01009,ko03019 - - - PFK k59_62981_2 1137799.GZ78_04645 3.39e-08 55.8 COG0591@1|root,COG0591@2|Bacteria,1MUBI@1224|Proteobacteria,1RMXU@1236|Gammaproteobacteria,1XI4B@135619|Oceanospirillales 1236|Gammaproteobacteria E Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family - - - ko:K11928 - - - - ko00000,ko02000 2.A.21.2 - - SSF k59_119351_1 1122132.AQYH01000002_gene1445 1.41e-59 208.0 COG0060@1|root,COG0060@2|Bacteria,1MVBQ@1224|Proteobacteria,2TR3N@28211|Alphaproteobacteria,4B8NI@82115|Rhizobiaceae 28211|Alphaproteobacteria J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) ileS - 6.1.1.5 ko:K01870 ko00970,map00970 M00359,M00360 R03656 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,tRNA-synt_1,zf-FPG_IleRS k59_1192517_1 717606.PaecuDRAFT_0475 2.12e-11 63.9 COG1307@1|root,COG1307@2|Bacteria,1TRM7@1239|Firmicutes,4HBIR@91061|Bacilli,26S8K@186822|Paenibacillaceae 91061|Bacilli S DegV family degV3 - - - - - - - - - - - DegV k59_1192517_2 1128421.JAGA01000002_gene938 2.77e-26 103.0 COG0302@1|root,COG0302@2|Bacteria,2NPAT@2323|unclassified Bacteria 2|Bacteria H GTP cyclohydrolase I folE GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003933,GO:0003934,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006066,GO:0006725,GO:0006729,GO:0006732,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009108,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019238,GO:0019438,GO:0019751,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034311,GO:0034312,GO:0034641,GO:0035639,GO:0036094,GO:0042558,GO:0042559,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046146,GO:0046165,GO:0046173,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 3.5.4.16 ko:K01495 ko00790,ko01100,map00790,map01100 M00126,M00841,M00842,M00843 R00428,R04639,R05046,R05048 RC00263,RC00294,RC00323,RC00945,RC01188 ko00000,ko00001,ko00002,ko01000 - - - GTP_cyclohydroI k59_627446_1 1178825.ALIH01000007_gene1621 4.35e-123 356.0 COG2267@1|root,COG2267@2|Bacteria,4PKJZ@976|Bacteroidetes,1IJBC@117743|Flavobacteriia 976|Bacteroidetes I Alpha beta hydrolase - - - - - - - - - - - - Abhydrolase_1 k59_627446_2 1484460.JSWG01000005_gene2686 3.11e-79 241.0 COG0854@1|root,COG0854@2|Bacteria,4NF4Z@976|Bacteroidetes,1HX38@117743|Flavobacteriia 976|Bacteroidetes H Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate pdxJ GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008614,GO:0008615,GO:0009058,GO:0009110,GO:0009987,GO:0016740,GO:0016769,GO:0017144,GO:0018130,GO:0019438,GO:0033856,GO:0034641,GO:0042364,GO:0042816,GO:0042819,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072524,GO:0072525,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 2.6.99.2 ko:K03474 ko00750,ko01100,map00750,map01100 M00124 R05838 RC01476 ko00000,ko00001,ko00002,ko01000 - - - PdxJ k59_909885_1 395019.Bmul_1960 1.35e-65 209.0 COG0604@1|root,COG0604@2|Bacteria,1MWRK@1224|Proteobacteria,2VJ1C@28216|Betaproteobacteria,1K27J@119060|Burkholderiaceae 28216|Betaproteobacteria C PFAM Alcohol dehydrogenase zinc-binding domain protein - - 1.6.5.5 ko:K00344 - - - - ko00000,ko01000 - - - ADH_N,ADH_zinc_N k59_1587614_1 1134474.O59_002163 1.35e-05 46.2 COG0316@1|root,COG0316@2|Bacteria,1RH6T@1224|Proteobacteria,1S5XD@1236|Gammaproteobacteria,1FHIC@10|Cellvibrio 1236|Gammaproteobacteria S Iron-sulphur cluster biosynthesis sufA - - ko:K05997,ko:K13628 - - - - ko00000,ko03016 - - - Fe-S_biosyn k59_1587614_2 984962.XP_009540429.1 1.89e-34 123.0 COG0251@1|root,KOG2317@2759|Eukaryota,3A5RT@33154|Opisthokonta,3P5AT@4751|Fungi,3V1QC@5204|Basidiomycota,229S8@155619|Agaricomycetes,3H5N8@355688|Agaricomycetes incertae sedis 4751|Fungi J YjgF-like protein - - 3.5.99.10 ko:K09022 - - R11098,R11099 RC03275,RC03354 ko00000,ko01000 - - - Ribonuc_L-PSP k59_1587614_3 986075.CathTA2_0642 1.48e-08 57.8 COG1012@1|root,COG1012@2|Bacteria,1TP4S@1239|Firmicutes,4H9MF@91061|Bacilli 91061|Bacilli C Belongs to the aldehyde dehydrogenase family aldHT_1 - - ko:K22187 ko00040,map00040 - R11768 RC00080 ko00000,ko00001,ko01000 - - - Aldedh k59_1023441_1 981369.JQMJ01000003_gene7894 9.01e-66 206.0 COG0634@1|root,COG0634@2|Bacteria,2GMDZ@201174|Actinobacteria,2NEBJ@228398|Streptacidiphilus 201174|Actinobacteria F Phosphoribosyl transferase domain hpt - 2.4.2.8 ko:K00760 ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 - R00190,R01132,R01229,R02142,R08237,R08238,R08245 RC00063,RC00122 ko00000,ko00001,ko01000 - - - Pribosyltran k59_1531585_1 717773.Thicy_1255 2.33e-07 52.4 COG0772@1|root,COG0772@2|Bacteria,1MUK3@1224|Proteobacteria,1RMEJ@1236|Gammaproteobacteria,460BS@72273|Thiotrichales 72273|Thiotrichales M Peptidoglycan polymerase that is essential for cell wall elongation mrdB - - ko:K05837 - - - - ko00000,ko03036 - - - FTSW_RODA_SPOVE k59_1531585_2 1064535.MELS_0687 5.21e-29 107.0 COG3118@1|root,COG3118@2|Bacteria,1VA3Y@1239|Firmicutes,4H5KC@909932|Negativicutes 909932|Negativicutes O Belongs to the thioredoxin family trxA - - ko:K03671 ko04621,ko05418,map04621,map05418 - - - ko00000,ko00001,ko03110 - - - Thioredoxin k59_1023444_1 323848.Nmul_A0787 6.52e-80 249.0 COG0201@1|root,COG0201@2|Bacteria,1MVU7@1224|Proteobacteria,2VHQH@28216|Betaproteobacteria,372DI@32003|Nitrosomonadales 28216|Betaproteobacteria U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently secY - - ko:K03076 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5 - - SecY k59_1023444_2 237368.SCABRO_03483 1.77e-05 42.7 COG0257@1|root,COG0257@2|Bacteria,2J1IK@203682|Planctomycetes 203682|Planctomycetes J Belongs to the bacterial ribosomal protein bL36 family rpmJ - - ko:K02919 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L36 k59_345445_1 1307761.L21SP2_2217 7.39e-59 198.0 COG0330@1|root,COG0330@2|Bacteria,2J73X@203691|Spirochaetes 203691|Spirochaetes O PFAM SPFH domain Band 7 family - - - - - - - - - - - - Band_7 k59_1757280_1 1122137.AQXF01000002_gene488 3.99e-73 232.0 COG1454@1|root,COG1454@2|Bacteria,1MVPH@1224|Proteobacteria,2TSX8@28211|Alphaproteobacteria 28211|Alphaproteobacteria C alcohol dehydrogenase - - 1.1.1.1 ko:K00001 ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220 - R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310 RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273 ko00000,ko00001,ko01000 - - - Fe-ADH k59_1757280_2 1122137.AQXF01000002_gene489 1.75e-176 503.0 COG1012@1|root,COG1012@2|Bacteria,1MVGW@1224|Proteobacteria,2TR9T@28211|Alphaproteobacteria 28211|Alphaproteobacteria C belongs to the aldehyde dehydrogenase family calB - 1.2.1.68,1.2.99.10 ko:K00154,ko:K22445 - - - - ko00000,ko01000 - - - Aldedh k59_458034_1 1300345.LF41_1595 1.18e-10 64.7 COG1273@1|root,COG1273@2|Bacteria,1MWCU@1224|Proteobacteria,1RYQ0@1236|Gammaproteobacteria,1X70Z@135614|Xanthomonadales 135614|Xanthomonadales S Protein of unknown function (DUF3426) - - - - - - - - - - - - DUF3426,zinc_ribbon_4 k59_458034_2 435908.IDSA_08195 8.95e-24 98.6 COG0042@1|root,COG0042@2|Bacteria,1MV5V@1224|Proteobacteria,1RMJP@1236|Gammaproteobacteria,2QFMK@267893|Idiomarinaceae 1236|Gammaproteobacteria J Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines dusB GO:0002943,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009314,GO:0009451,GO:0009628,GO:0009987,GO:0010467,GO:0016070,GO:0016491,GO:0016627,GO:0017150,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0050896,GO:0055114,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 - ko:K05540 - - - - ko00000,ko01000,ko03016 - - - Dus k59_1531601_1 436308.Nmar_1767 1.41e-201 566.0 COG0484@1|root,arCOG02846@2157|Archaea,41T1F@651137|Thaumarchaeota 651137|Thaumarchaeota O DnaJ molecular chaperone homology domain - - - - - - - - - - - - DnaJ k59_1700733_1 316407.85676106 4.53e-152 441.0 COG2194@1|root,COG2194@2|Bacteria,1MWS7@1224|Proteobacteria,1RQI2@1236|Gammaproteobacteria,3XMV4@561|Escherichia 1236|Gammaproteobacteria S Catalyzes the addition of a phosphoethanolamine moiety to the outer membrane lipopolysaccharide core cptA GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016740,GO:0016772,GO:0016776,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044464,GO:0046401,GO:0071704,GO:0071944,GO:1901135,GO:1901137,GO:1901576,GO:1903509 - ko:K19353 ko00540,map00540 - - - ko00000,ko00001,ko01000,ko01005 - - - DUF1705,Sulfatase k59_853790_1 158500.BV97_02337 3.49e-107 324.0 COG4993@1|root,COG4993@2|Bacteria,1MUQX@1224|Proteobacteria,2TS2Q@28211|Alphaproteobacteria,2K18E@204457|Sphingomonadales 204457|Sphingomonadales CG Dehydrogenase - - 1.1.2.8 ko:K00114 ko00010,ko00625,ko01100,ko01110,ko01120,ko01130,map00010,map00625,map01100,map01110,map01120,map01130 - R05062,R05198,R05285 RC00087,RC00088,RC01039 ko00000,ko00001,ko01000 - - - PQQ k59_1418195_1 1123499.KB908018_gene2118 7.94e-12 67.8 COG1686@1|root,COG1686@2|Bacteria,1MWZA@1224|Proteobacteria,2VH1S@28216|Betaproteobacteria,2KPUP@206351|Neisseriales 206351|Neisseriales M Belongs to the peptidase S11 family pbpG - - ko:K07262 - - - - ko00000,ko01000,ko01002,ko01011 - - - Peptidase_S11 k59_63030_1 436308.Nmar_0976 2.42e-97 292.0 COG0614@1|root,arCOG04233@2157|Archaea,41SXD@651137|Thaumarchaeota 651137|Thaumarchaeota P Periplasmic binding protein - - - ko:K02016 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko02000 3.A.1.14 - - Peripla_BP_2 k59_1531618_1 1380600.AUYN01000001_gene2435 2.25e-62 196.0 2DEWU@1|root,2ZPJP@2|Bacteria,4NPJW@976|Bacteroidetes,1I25Z@117743|Flavobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_1531618_2 411154.GFO_2270 1.56e-19 82.8 COG0691@1|root,COG0691@2|Bacteria,4NNJU@976|Bacteroidetes,1I191@117743|Flavobacteriia 976|Bacteroidetes O the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA smpB - - ko:K03664 - - - - ko00000 - - - SmpB k59_1587646_1 1168065.DOK_12326 3.88e-83 256.0 COG0667@1|root,COG0667@2|Bacteria,1MVEH@1224|Proteobacteria,1RPX5@1236|Gammaproteobacteria,1JBV4@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C oxidoreductases (related to aryl-alcohol dehydrogenases) - - - - - - - - - - - - Aldo_ket_red k59_1079244_2 754476.Q7A_2453 8.39e-42 145.0 COG1496@1|root,COG1496@2|Bacteria,1MW2H@1224|Proteobacteria,1RNV4@1236|Gammaproteobacteria,460JQ@72273|Thiotrichales 72273|Thiotrichales S Belongs to the multicopper oxidase YfiH RL5 family - - - ko:K05810 - - - - ko00000,ko01000 - - - Cu-oxidase_4 k59_357221_17 56780.SYN_03379 7.91e-15 77.0 2CDSP@1|root,32RYD@2|Bacteria,1N213@1224|Proteobacteria,42U4H@68525|delta/epsilon subdivisions,2WQTU@28221|Deltaproteobacteria,2MSDT@213462|Syntrophobacterales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_1429628_2 465515.Mlut_17580 3.26e-11 64.7 COG1228@1|root,COG1228@2|Bacteria,2I9IW@201174|Actinobacteria,1W8Q4@1268|Micrococcaceae 201174|Actinobacteria Q Amidohydrolase family - - - - - - - - - - - - Amidohydro_1,Amidohydro_3 k59_243388_2 439481.Aboo_0326 2.35e-07 58.2 COG1524@1|root,arCOG01378@2157|Archaea,2XVGR@28890|Euryarchaeota,3F33R@33867|unclassified Euryarchaeota 28890|Euryarchaeota S PFAM type I phosphodiesterase nucleotide pyrophosphatase - - - - - - - - - - - - Phosphodiest k59_300717_1 493475.GARC_0300 6.7e-25 104.0 COG0668@1|root,COG0668@2|Bacteria,1N2GE@1224|Proteobacteria,1SBRX@1236|Gammaproteobacteria 1236|Gammaproteobacteria M COG0668 Small-conductance mechanosensitive channel cmpX - - - - - - - - - - - MS_channel,TM_helix k59_1599337_1 1088721.NSU_1948 4.02e-47 156.0 2ATYG@1|root,31JI4@2|Bacteria,1N46N@1224|Proteobacteria,2UCQE@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_1599337_2 555793.WSK_3164 4.57e-75 237.0 COG5323@1|root,COG5323@2|Bacteria,1MW8S@1224|Proteobacteria,2TREI@28211|Alphaproteobacteria,2K2BG@204457|Sphingomonadales 204457|Sphingomonadales S Terminase RNaseH-like domain - - - - - - - - - - - - Terminase_6,Terminase_6C k59_582391_1 1280953.HOC_01616 1.82e-83 261.0 COG4402@1|root,COG4402@2|Bacteria,1MVMM@1224|Proteobacteria,2U464@28211|Alphaproteobacteria,43WAC@69657|Hyphomonadaceae 28211|Alphaproteobacteria S Uncharacterized protein conserved in bacteria (DUF2330) - - - - - - - - - - - - DUF2330 k59_808900_1 1125863.JAFN01000001_gene3296 4.72e-09 55.8 COG0088@1|root,COG0088@2|Bacteria,1MXPF@1224|Proteobacteria,42MPW@68525|delta/epsilon subdivisions,2WN96@28221|Deltaproteobacteria 28221|Deltaproteobacteria J One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome rplD GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02926 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L4 k59_808900_2 1125863.JAFN01000001_gene3295 4.48e-58 185.0 COG0087@1|root,COG0087@2|Bacteria,1MUST@1224|Proteobacteria,42NV2@68525|delta/epsilon subdivisions,2WNJ1@28221|Deltaproteobacteria 28221|Deltaproteobacteria J One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit rplC - - ko:K02906 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L3 k59_187532_2 493475.GARC_4353 0.000215 46.2 COG1033@1|root,COG1033@2|Bacteria,1MUE1@1224|Proteobacteria,1RNWM@1236|Gammaproteobacteria,465X0@72275|Alteromonadaceae 1236|Gammaproteobacteria S exporters of the RND superfamily - - - ko:K07003 - - - - ko00000 - - - MMPL k59_243398_1 222534.KB893728_gene5512 6.22e-15 74.7 COG1028@1|root,COG1309@1|root,COG1028@2|Bacteria,COG1309@2|Bacteria,2GK20@201174|Actinobacteria,4EUIF@85013|Frankiales 201174|Actinobacteria IQ KR domain - - - - - - - - - - - - adh_short_C2 k59_74958_1 395965.Msil_1418 2.89e-65 215.0 COG0457@1|root,COG3710@1|root,COG5616@1|root,COG0457@2|Bacteria,COG3710@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2TRUI@28211|Alphaproteobacteria,3NCQR@45404|Beijerinckiaceae 28211|Alphaproteobacteria K Adenylate cyclase - - - - - - - - - - - - BTAD,Trans_reg_C k59_130751_1 1120950.KB892786_gene117 4.47e-57 198.0 COG3540@1|root,COG3540@2|Bacteria,2GJCI@201174|Actinobacteria,4DN41@85009|Propionibacteriales 201174|Actinobacteria P PhoD-like phosphatase, N-terminal domain phoD - 3.1.3.1 ko:K01113 ko00790,ko01100,ko02020,map00790,map01100,map02020 M00126 R04620 RC00017 ko00000,ko00001,ko00002,ko01000 - - - PhoD,PhoD_N k59_243402_1 1096930.L284_03270 1.42e-21 94.0 COG0443@1|root,COG0443@2|Bacteria,1MVEN@1224|Proteobacteria,2TR5H@28211|Alphaproteobacteria,2K1KK@204457|Sphingomonadales 204457|Sphingomonadales O Heat shock 70 kDa protein dnaK - - ko:K04043 ko03018,ko04212,ko05152,map03018,map04212,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 1.A.33.1 - - HSP70 k59_243402_2 702113.PP1Y_AT25594 2.26e-42 149.0 COG0484@1|root,COG0484@2|Bacteria,1MVMS@1224|Proteobacteria,2TRZ1@28211|Alphaproteobacteria,2K1EY@204457|Sphingomonadales 204457|Sphingomonadales O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins dnaJ - - ko:K03686 - - - - ko00000,ko03029,ko03110 - - - DnaJ,DnaJ_C,DnaJ_CXXCXGXG k59_525323_1 583345.Mmol_2332 6.68e-63 202.0 COG0224@1|root,COG0224@2|Bacteria,1MU28@1224|Proteobacteria,2VJBW@28216|Betaproteobacteria,2KKJZ@206350|Nitrosomonadales 206350|Nitrosomonadales C Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex atpG - - ko:K02115 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt k59_1147266_1 1500894.JQNN01000001_gene2813 8.25e-19 87.0 COG1894@1|root,COG1894@2|Bacteria,1MV8F@1224|Proteobacteria,2VIMM@28216|Betaproteobacteria,473CK@75682|Oxalobacteraceae 28216|Betaproteobacteria C NADH-ubiquinone oxidoreductase-F iron-sulfur binding region fdwB - 1.17.1.9 ko:K00122 ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200 - R00519 RC02796 ko00000,ko00001,ko01000 - - - 2Fe-2S_thioredx,Complex1_51K,NADH_4Fe-4S,SLBB k59_1147266_2 1485544.JQKP01000004_gene490 3.27e-56 182.0 COG0074@1|root,COG0074@2|Bacteria,1MUGA@1224|Proteobacteria,2VH1U@28216|Betaproteobacteria,44V0Q@713636|Nitrosomonadales 28216|Betaproteobacteria C Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit sucD GO:0003674,GO:0003824,GO:0004774,GO:0004776,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0016874,GO:0016877,GO:0016878,GO:0031974,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0070013 6.2.1.5 ko:K01902 ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374,M00620 R00405,R02404 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000 - - - CoA_binding,Ligase_CoA k59_412990_1 1454004.AW11_02488 6.66e-35 132.0 COG0394@1|root,COG0704@1|root,COG0394@2|Bacteria,COG0704@2|Bacteria 2|Bacteria P negative regulation of phosphate transmembrane transport phoU GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009892,GO:0010563,GO:0010966,GO:0019220,GO:0019222,GO:0031323,GO:0031324,GO:0032879,GO:0034762,GO:0034763,GO:0034765,GO:0034766,GO:0042802,GO:0042803,GO:0043269,GO:0043271,GO:0044070,GO:0044424,GO:0044464,GO:0045936,GO:0046983,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051049,GO:0051051,GO:0051174,GO:0065007,GO:1903792,GO:1903795,GO:1903796,GO:1903959,GO:1903960,GO:2000185,GO:2000186 1.20.4.1,3.1.3.48 ko:K01104,ko:K02039,ko:K03741 - - - - ko00000,ko01000 - - - PhoU k59_1204120_1 1280946.HY29_03775 6.42e-58 192.0 COG1804@1|root,COG1804@2|Bacteria,1MU5U@1224|Proteobacteria,2TRIZ@28211|Alphaproteobacteria 28211|Alphaproteobacteria C L-carnitine dehydratase bile acid-inducible protein F - - - - - - - - - - - - CoA_transf_3 k59_357256_1 1229909.NSED_08805 1.13e-35 125.0 COG3794@1|root,arCOG02929@2157|Archaea,41T61@651137|Thaumarchaeota 651137|Thaumarchaeota C Cupredoxin-like domain - - - - - - - - - - - - Cupredoxin_1 k59_1317403_1 279238.Saro_2712 7.01e-193 546.0 COG3598@1|root,COG3598@2|Bacteria,1R4V4@1224|Proteobacteria,2TTYV@28211|Alphaproteobacteria 28211|Alphaproteobacteria L AAA domain - - - ko:K07505 - - - - ko00000 - - - AAA_25,Prim-Pol k59_413017_1 1254432.SCE1572_36535 1.57e-08 54.7 COG0479@1|root,COG0479@2|Bacteria,1QVWG@1224|Proteobacteria,43BWA@68525|delta/epsilon subdivisions,2X771@28221|Deltaproteobacteria,2YUJP@29|Myxococcales 28221|Deltaproteobacteria C 4Fe-4S dicluster domain - - - - - - - - - - - - Fer4_22 k59_413017_2 521719.ATXQ01000002_gene2349 5.31e-05 49.7 COG0664@1|root,COG0664@2|Bacteria,1R5P7@1224|Proteobacteria,1S6X3@1236|Gammaproteobacteria,1YF0M@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria K helix_turn_helix, cAMP Regulatory protein dnr - - ko:K21563 - - - - ko00000,ko03000 - - - HTH_Crp_2,cNMP_binding k59_413017_3 395961.Cyan7425_2662 1.15e-11 66.2 COG0543@1|root,COG0543@2|Bacteria 2|Bacteria C 2 iron, 2 sulfur cluster binding asrB - - ko:K02823 ko00240,ko01100,map00240,map01100 - - - ko00000,ko00001 - - - DHODB_Fe-S_bind,FAD_binding_6,NAD_binding_1 k59_300756_1 436308.Nmar_0404 8.6e-50 168.0 COG1422@1|root,arCOG02673@2157|Archaea,41SNR@651137|Thaumarchaeota 651137|Thaumarchaeota U membrane - - - - - - - - - - - - DUF106 k59_300756_2 986075.CathTA2_0405 7.77e-34 144.0 COG5001@1|root,COG5001@2|Bacteria,1TP8V@1239|Firmicutes,4HA3G@91061|Bacilli 91061|Bacilli T Diguanylate cyclase - - - - - - - - - - - - EAL,GGDEF k59_243417_1 886377.Murru_2046 1.49e-87 280.0 COG0168@1|root,COG0168@2|Bacteria,4NGMF@976|Bacteroidetes,1HXPV@117743|Flavobacteriia 976|Bacteroidetes P Trk-type K transport systems, membrane components trkH - - ko:K03498 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - - TrkH k59_1204131_1 1415778.JQMM01000001_gene111 1.01e-29 117.0 COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,1MU7B@1224|Proteobacteria,1RN2W@1236|Gammaproteobacteria,1J55M@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Glutamate synthase domain gltB GO:0003674,GO:0003824,GO:0004355,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006541,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0015930,GO:0016053,GO:0016491,GO:0016638,GO:0016639,GO:0019676,GO:0019740,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045181,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.4.1.13,1.4.1.14 ko:K00265 ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 - R00093,R00114,R00248 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - iBWG_1329.BWG_2914,iECDH10B_1368.ECDH10B_3387,iECDH1ME8569_1439.EcDH1_0495,iEcDH1_1363.EcDH1_0495,iPC815.YPO3557 GATase_2,GXGXG,Glu_syn_central,Glu_synthase k59_751920_1 111780.Sta7437_1344 7.44e-32 125.0 COG2227@1|root,COG2227@2|Bacteria,1G2VI@1117|Cyanobacteria,3VMCM@52604|Pleurocapsales 1117|Cyanobacteria H C-methyltransferase C-terminal domain - - - - - - - - - - - - Methyltransf_13,Methyltransf_14,Methyltransf_23 k59_17803_1 228410.NE2476 2.08e-32 125.0 COG0445@1|root,COG0445@2|Bacteria,1MU6F@1224|Proteobacteria,2VIGG@28216|Betaproteobacteria,371SY@32003|Nitrosomonadales 28216|Betaproteobacteria D NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 gidA - - ko:K03495 - - R08701 RC00053,RC00209,RC00870 ko00000,ko03016,ko03036 - - - GIDA,GIDA_assoc k59_17803_2 977880.RALTA_A3102 8.12e-14 70.9 COG0357@1|root,COG0357@2|Bacteria,1MY0K@1224|Proteobacteria,2VR3B@28216|Betaproteobacteria,1K0RU@119060|Burkholderiaceae 28216|Betaproteobacteria J Specifically methylates the N7 position of guanine in position 527 of 16S rRNA rsmG - 2.1.1.170 ko:K03501 - - - - ko00000,ko01000,ko03009,ko03036 - - - GidB k59_808961_1 1396858.Q666_07380 1.95e-83 263.0 COG0644@1|root,COG0644@2|Bacteria,1MXQY@1224|Proteobacteria,1SEJ8@1236|Gammaproteobacteria 1236|Gammaproteobacteria C geranylgeranyl reductase - - - - - - - - - - - - FAD_binding_3 k59_808965_1 1121935.AQXX01000112_gene5703 2.17e-102 303.0 COG1117@1|root,COG1117@2|Bacteria,1MU16@1224|Proteobacteria,1RNUF@1236|Gammaproteobacteria,1XHJU@135619|Oceanospirillales 135619|Oceanospirillales P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system pstB - 3.6.3.27 ko:K02036 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.7 - - ABC_tran k59_469425_2 160492.XF_0278 1.92e-26 103.0 COG0515@1|root,COG0515@2|Bacteria,1N75K@1224|Proteobacteria,1RZ61@1236|Gammaproteobacteria,1X5C5@135614|Xanthomonadales 135614|Xanthomonadales KLT serine threonine protein kinase - - - - - - - - - - - - APH k59_1090807_1 316407.85676242 2e-42 138.0 COG5567@1|root,COG5567@2|Bacteria,1N70H@1224|Proteobacteria,1SDC8@1236|Gammaproteobacteria,3XPYT@561|Escherichia 1236|Gammaproteobacteria N Prokaryotic lipoprotein-attachment site yifL - - - - - - - - - - - LPAM_2 k59_1090807_2 1397284.AYMN01000004_gene3015 6.07e-38 134.0 COG0253@1|root,COG0253@2|Bacteria,1MWDH@1224|Proteobacteria,1RMGV@1236|Gammaproteobacteria,401MV@613|Serratia 1236|Gammaproteobacteria E Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan dapF GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008837,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016853,GO:0016854,GO:0016855,GO:0019752,GO:0036361,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0047661,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.1.1.7 ko:K01778 ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00527 R02735 RC00302 ko00000,ko00001,ko00002,ko01000 - - iECED1_1282.ECED1_4494 DAP_epimerase k59_1543298_1 1120959.ATXF01000004_gene3133 3.51e-11 70.9 COG2304@1|root,COG2304@2|Bacteria,2IPKX@201174|Actinobacteria,4FSE7@85023|Microbacteriaceae 201174|Actinobacteria S oxidoreductase activity - - - - - - - - - - - - - k59_1768948_1 512565.AMIS_31080 5.84e-43 148.0 2BPUP@1|root,32IN9@2|Bacteria,2H785@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - - k59_1260248_2 1278073.MYSTI_06315 3.46e-13 67.4 28S5K@1|root,2ZEH5@2|Bacteria,1NI42@1224|Proteobacteria 1224|Proteobacteria S Protein of unknown function (FYDLN_acid) - - - - - - - - - - - - FYDLN_acid k59_1543299_1 159087.Daro_2239 1.24e-52 183.0 28IYI@1|root,2Z8W8@2|Bacteria,1R8BG@1224|Proteobacteria,2VNFN@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_300819_1 637389.Acaty_c1454 6.32e-11 67.0 COG1187@1|root,COG1187@2|Bacteria,1MUCE@1224|Proteobacteria,1RQU0@1236|Gammaproteobacteria,2NC1T@225057|Acidithiobacillales 225057|Acidithiobacillales J Belongs to the pseudouridine synthase RsuA family - - 5.4.99.22 ko:K06178 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2,S4 k59_1543303_1 1123256.KB907934_gene2393 5.33e-46 166.0 COG4805@1|root,COG4805@2|Bacteria,1PIM6@1224|Proteobacteria,1RRW7@1236|Gammaproteobacteria,1X3BX@135614|Xanthomonadales 135614|Xanthomonadales S Bacterial protein of unknown function (DUF885) - - - - - - - - - - - - DUF885 k59_1712356_1 1095769.CAHF01000022_gene253 5.66e-48 173.0 COG1073@1|root,COG1073@2|Bacteria 2|Bacteria S thiolester hydrolase activity - - - - - - - - - - - - Abhydrolase_1,Abhydrolase_6 k59_1768955_1 882378.RBRH_00960 1.33e-50 182.0 COG0187@1|root,COG0187@2|Bacteria,1MVKT@1224|Proteobacteria,2VI8N@28216|Betaproteobacteria,1K194@119060|Burkholderiaceae 28216|Betaproteobacteria L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrB - 5.99.1.3 ko:K02470 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim k59_1487272_1 436308.Nmar_1255 1.95e-56 183.0 arCOG08778@1|root,arCOG08778@2157|Archaea,41T5W@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1429750_1 1323663.AROI01000021_gene898 3.32e-132 387.0 COG3278@1|root,COG3278@2|Bacteria,1MU18@1224|Proteobacteria,1RM7I@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Belongs to the heme-copper respiratory oxidase family ccoN GO:0003674,GO:0003824,GO:0004129,GO:0005215,GO:0005488,GO:0005506,GO:0005507,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006119,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008144,GO:0008150,GO:0008152,GO:0008324,GO:0009055,GO:0009060,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015002,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015672,GO:0015975,GO:0015980,GO:0015988,GO:0015990,GO:0016020,GO:0016021,GO:0016310,GO:0016491,GO:0016675,GO:0016676,GO:0016705,GO:0017144,GO:0019411,GO:0019637,GO:0019646,GO:0019693,GO:0019825,GO:0020037,GO:0022857,GO:0022890,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0032991,GO:0034220,GO:0034641,GO:0036094,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0045154,GO:0045333,GO:0046034,GO:0046483,GO:0046872,GO:0046906,GO:0046914,GO:0048037,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0055114,GO:0070069,GO:0070469,GO:0070470,GO:0071704,GO:0071944,GO:0072521,GO:0097159,GO:0098655,GO:0098660,GO:0098662,GO:1901135,GO:1901360,GO:1901363,GO:1901564,GO:1902600 1.9.3.1 ko:K00404 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00156 - - ko00000,ko00001,ko00002,ko01000 3.D.4.3 - - COX1 k59_525391_1 1122137.AQXF01000001_gene3161 1.76e-93 304.0 COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,1MU7B@1224|Proteobacteria,2TRHQ@28211|Alphaproteobacteria 28211|Alphaproteobacteria E glutamate synthase gltB - 1.4.1.13,1.4.1.14,1.4.7.1 ko:K00265,ko:K00284 ko00250,ko00630,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00630,map00910,map01100,map01110,map01120,map01130,map01230 - R00021,R00093,R00114,R00248,R10086 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - GATase_2,GXGXG,Glu_syn_central,Glu_synthase k59_1656657_2 1122612.AUBA01000002_gene1876 1.09e-55 193.0 COG4773@1|root,COG4773@2|Bacteria,1NXPR@1224|Proteobacteria,2U161@28211|Alphaproteobacteria 28211|Alphaproteobacteria P TonB-dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_243464_1 1298593.TOL_0793 2.22e-29 109.0 COG2001@1|root,COG2001@2|Bacteria,1RHCG@1224|Proteobacteria,1S63F@1236|Gammaproteobacteria,1XJJI@135619|Oceanospirillales 135619|Oceanospirillales K Belongs to the MraZ family mraZ - - ko:K03925 - - - - ko00000 - - - MraZ k59_1090854_2 298654.FraEuI1c_1766 4.04e-18 84.7 COG1403@1|root,COG1403@2|Bacteria,2GP2N@201174|Actinobacteria,4ET3J@85013|Frankiales 201174|Actinobacteria L HNH endonuclease - GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 - - - - - - - - - - DUF222,HNH k59_130839_1 2340.JV46_14280 1.07e-80 253.0 COG1156@1|root,COG1156@2|Bacteria,1QUQE@1224|Proteobacteria,1T210@1236|Gammaproteobacteria,1JC0C@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit - - - - - - - - - - - - ATP-synt_ab k59_75054_1 27923.ML18931a-PA 4.35e-15 84.0 COG2937@1|root,KOG3730@2759|Eukaryota,38CW0@33154|Opisthokonta,3BB7J@33208|Metazoa 33208|Metazoa I glycerone-phosphate O-acyltransferase activity GNPAT GO:0001101,GO:0003674,GO:0003824,GO:0005102,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005777,GO:0005778,GO:0005782,GO:0005829,GO:0006605,GO:0006625,GO:0006629,GO:0006644,GO:0006650,GO:0006654,GO:0006662,GO:0006793,GO:0006796,GO:0006810,GO:0006886,GO:0006950,GO:0006996,GO:0007031,GO:0007043,GO:0007272,GO:0007275,GO:0007399,GO:0007416,GO:0007417,GO:0007420,GO:0007584,GO:0008104,GO:0008150,GO:0008152,GO:0008366,GO:0008374,GO:0008610,GO:0008611,GO:0008654,GO:0009058,GO:0009605,GO:0009653,GO:0009987,GO:0009991,GO:0010033,GO:0010927,GO:0015031,GO:0015833,GO:0016020,GO:0016043,GO:0016287,GO:0016289,GO:0016290,GO:0016407,GO:0016413,GO:0016740,GO:0016746,GO:0016747,GO:0016787,GO:0016788,GO:0016790,GO:0018904,GO:0019637,GO:0021549,GO:0021575,GO:0021587,GO:0022037,GO:0022607,GO:0030902,GO:0030913,GO:0031090,GO:0031667,GO:0031903,GO:0031907,GO:0031974,GO:0032288,GO:0032501,GO:0032502,GO:0032989,GO:0033036,GO:0033365,GO:0033993,GO:0034329,GO:0034330,GO:0034613,GO:0042221,GO:0042493,GO:0042552,GO:0042579,GO:0042594,GO:0042886,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043574,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044422,GO:0044424,GO:0044438,GO:0044439,GO:0044444,GO:0044446,GO:0044464,GO:0045017,GO:0045184,GO:0045216,GO:0046473,GO:0046474,GO:0046485,GO:0046486,GO:0046504,GO:0046907,GO:0047617,GO:0048513,GO:0048646,GO:0048731,GO:0048856,GO:0048869,GO:0050808,GO:0050896,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0060322,GO:0061024,GO:0070013,GO:0070542,GO:0070727,GO:0071702,GO:0071704,GO:0071705,GO:0071840,GO:0072594,GO:0072662,GO:0072663,GO:0090407,GO:0097384,GO:0098588,GO:0098805,GO:1901503,GO:1901576,GO:1901700 2.3.1.42 ko:K00649 ko00564,ko04146,map00564,map04146 - R01013 RC00004,RC00041 ko00000,ko00001,ko01000 - - - Acyltransferase k59_1204183_1 511145.b2022 1.22e-38 137.0 COG0131@1|root,COG0241@1|root,COG0131@2|Bacteria,COG0241@2|Bacteria,1MWBS@1224|Proteobacteria,1RPA9@1236|Gammaproteobacteria,3XMA4@561|Escherichia 1236|Gammaproteobacteria E Histidine biosynthesis bifunctional protein HisB hisB GO:0000105,GO:0003674,GO:0003824,GO:0004401,GO:0004424,GO:0005488,GO:0005515,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042578,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 3.1.3.15,4.2.1.19 ko:K01089,ko:K01693 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R03013,R03457 RC00017,RC00932 ko00000,ko00001,ko00002,ko01000 - - iECO111_1330.ECO111_2746,iECS88_1305.ECS88_2121,iJN746.PP_0289,iUMNK88_1353.UMNK88_2570 Hydrolase_like,IGPD,PNK3P k59_470360_1 349521.HCH_02183 3.34e-48 165.0 COG1426@1|root,COG1426@2|Bacteria,1RIIX@1224|Proteobacteria,1S62E@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Protein conserved in bacteria - - - - - - - - - - - - - k59_1318375_1 316407.85674819 4.99e-220 605.0 COG2801@1|root,COG2801@2|Bacteria,1MVXQ@1224|Proteobacteria,1RR4F@1236|Gammaproteobacteria 1236|Gammaproteobacteria L COG2801 Transposase and inactivated derivatives insF GO:0008150,GO:0009987,GO:0032196 - ko:K07497 - - - - ko00000 - - - HTH_21,rve k59_1318375_2 316407.85675214 8.31e-57 177.0 COG2963@1|root,COG2963@2|Bacteria,1RHBZ@1224|Proteobacteria,1S69Y@1236|Gammaproteobacteria,3XR2P@561|Escherichia 1236|Gammaproteobacteria L transposase activity - GO:0005575,GO:0005623,GO:0006139,GO:0006259,GO:0006310,GO:0006313,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009279,GO:0009405,GO:0009987,GO:0016020,GO:0019867,GO:0030260,GO:0030312,GO:0030313,GO:0031975,GO:0032196,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044403,GO:0044409,GO:0044419,GO:0044462,GO:0044464,GO:0046483,GO:0051701,GO:0051704,GO:0051806,GO:0051828,GO:0071704,GO:0071944,GO:0090304,GO:1901360 - ko:K07483 - - - - ko00000 - - - HTH_Tnp_1 k59_1318375_3 481805.EcolC_2568 1.54e-53 168.0 COG0331@1|root,COG0331@2|Bacteria 2|Bacteria I [acyl-carrier-protein] S-malonyltransferase activity fabD - 2.3.1.39 ko:K00645,ko:K15327,ko:K15329,ko:K15355,ko:K15469 ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212 M00082 R01626,R11671 RC00004,RC00039,RC02727 ko00000,ko00001,ko00002,ko01000,ko01004,ko01008 - - iEcE24377_1341.EcE24377A_1213 Acyl_transf_1,NMO k59_922487_1 1122137.AQXF01000005_gene1305 5.13e-91 278.0 COG0845@1|root,COG0845@2|Bacteria,1PEVY@1224|Proteobacteria,2VF2W@28211|Alphaproteobacteria 28211|Alphaproteobacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - - - - - - - - - - Biotin_lipoyl_2,HlyD_3 k59_1148163_1 1118235.CAJH01000005_gene412 3.91e-22 91.7 COG5394@1|root,COG5394@2|Bacteria,1RHRC@1224|Proteobacteria,1S2XX@1236|Gammaproteobacteria,1XC5X@135614|Xanthomonadales 135614|Xanthomonadales S synthesis repressor, PhaR phaR - - - - - - - - - - - PHB_acc,PHB_acc_N k59_1713177_1 316407.85676960 2.99e-151 425.0 COG2846@1|root,COG2846@2|Bacteria,1MVCQ@1224|Proteobacteria,1RPY6@1236|Gammaproteobacteria,3XMW2@561|Escherichia 1236|Gammaproteobacteria D Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions ytfE GO:0003674,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0016226,GO:0018282,GO:0018283,GO:0019538,GO:0022607,GO:0030091,GO:0031163,GO:0036211,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0051186,GO:0071704,GO:0071840,GO:1901564 - ko:K07322 - - - - ko00000 - - iECED1_1282.ECED1_5068,iECH74115_1262.ECH74115_5726,iECSP_1301.ECSP_5311,iECs_1301.ECs5187,iG2583_1286.G2583_5039,iZ_1308.Z5820 Hemerythrin,ScdA_N k59_1657556_1 493475.GARC_3471 3.97e-65 213.0 COG0577@1|root,COG0577@2|Bacteria,1MXFC@1224|Proteobacteria,1RQX0@1236|Gammaproteobacteria,46698@72275|Alteromonadaceae 1236|Gammaproteobacteria V FtsX-like permease family - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_188376_1 1122137.AQXF01000001_gene3124 1.58e-113 340.0 COG1502@1|root,COG1502@2|Bacteria,1MWUW@1224|Proteobacteria,2TUW3@28211|Alphaproteobacteria 28211|Alphaproteobacteria I Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol cls - - ko:K06131 ko00564,ko01100,map00564,map01100 - R07390 RC00017 ko00000,ko00001,ko01000 - - - PLDc_2,PLDc_N k59_1046018_1 493475.GARC_3274 7.98e-74 232.0 COG4977@1|root,COG4977@2|Bacteria,1MUDK@1224|Proteobacteria,1RP9W@1236|Gammaproteobacteria,464RD@72275|Alteromonadaceae 1236|Gammaproteobacteria K DJ-1/PfpI family - - - - - - - - - - - - DJ-1_PfpI,HTH_18 k59_1046018_2 377629.TERTU_1616 1.77e-52 173.0 COG2227@1|root,COG2227@2|Bacteria,1R9ZR@1224|Proteobacteria,1S27B@1236|Gammaproteobacteria,2PNN5@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria H Methyltransferase domain - - - - - - - - - - - - Methyltransf_23 k59_367990_1 1205680.CAKO01000010_gene3901 9.61e-46 159.0 COG4177@1|root,COG4177@2|Bacteria,1PSHZ@1224|Proteobacteria,2TVQQ@28211|Alphaproteobacteria,2JVEV@204441|Rhodospirillales 204441|Rhodospirillales E Branched-chain amino acid transport system / permease component - - - - - - - - - - - - BPD_transp_2 k59_876314_1 1454004.AW11_02485 1.39e-81 249.0 COG1117@1|root,COG1117@2|Bacteria,1MU16@1224|Proteobacteria,2VI4J@28216|Betaproteobacteria 28216|Betaproteobacteria P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system - - - - - - - - - - - - ABC_tran k59_1156508_1 247634.GPB2148_2488 5.41e-26 103.0 COG1682@1|root,COG1682@2|Bacteria,1N0X3@1224|Proteobacteria,1S2H4@1236|Gammaproteobacteria,1J6FE@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P COG1682 ABC-type polysaccharide polyol phosphate export systems, permease component - - - ko:K09690 ko02010,map02010 M00250 - - ko00000,ko00001,ko00002,ko02000 3.A.1.103 - - ABC2_membrane k59_1156508_2 96561.Dole_1285 1.4e-07 53.5 COG1134@1|root,COG1134@2|Bacteria,1MWWC@1224|Proteobacteria,42NNW@68525|delta/epsilon subdivisions,2WMWA@28221|Deltaproteobacteria,2MJQ5@213118|Desulfobacterales 28221|Deltaproteobacteria GM PFAM ABC transporter - - - ko:K09691 ko02010,map02010 M00250 - - ko00000,ko00001,ko00002,ko02000 3.A.1.103 - - ABC_tran,Wzt_C k59_421781_1 448385.sce4835 5.23e-57 190.0 COG0820@1|root,COG0820@2|Bacteria,1MUYK@1224|Proteobacteria,42N69@68525|delta/epsilon subdivisions,2WIUJ@28221|Deltaproteobacteria,2YURZ@29|Myxococcales 28221|Deltaproteobacteria J Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs rlmN GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0022613,GO:0030488,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140101,GO:0140102,GO:1901360 2.1.1.192 ko:K06941 - - - - ko00000,ko01000,ko03009 - - - Fer4_14,Radical_SAM k59_28480_1 471854.Dfer_0171 7.97e-26 112.0 COG0745@1|root,COG2198@1|root,COG5002@1|root,COG5278@1|root,COG0745@2|Bacteria,COG2198@2|Bacteria,COG5002@2|Bacteria,COG5278@2|Bacteria,4P0IA@976|Bacteroidetes,47Y5H@768503|Cytophagia 976|Bacteroidetes T CHASE3 domain - - - - - - - - - - - - CHASE3,Guanylate_cyc,HATPase_c,HisKA,PAS_3,PAS_4,PAS_9,Response_reg,TPR_12 k59_646977_1 1168065.DOK_16273 4.04e-101 322.0 COG1629@1|root,COG1629@2|Bacteria,COG4771@2|Bacteria,1MUWN@1224|Proteobacteria,1S005@1236|Gammaproteobacteria,1J8XF@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P Outer membrane protein beta-barrel family - - - - - - - - - - - - Plug,TonB_dep_Rec k59_1384346_1 1208321.D104_10880 2.75e-11 64.3 COG1448@1|root,COG1448@2|Bacteria,1MUT0@1224|Proteobacteria,1RN02@1236|Gammaproteobacteria,1XH9R@135619|Oceanospirillales 135619|Oceanospirillales E Aminotransferase - - 2.6.1.1,2.6.1.57 ko:K00813,ko:K00832 ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230 M00024,M00025,M00034,M00040 R00355,R00694,R00734,R00896,R01731,R02433,R02619,R05052,R07396,R10845 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 k59_1384346_2 1218076.BAYB01000014_gene3051 2.5e-110 328.0 COG0491@1|root,COG0491@2|Bacteria,1MURA@1224|Proteobacteria,2VJYK@28216|Betaproteobacteria,1K220@119060|Burkholderiaceae 28216|Betaproteobacteria P PFAM beta-lactamase domain protein baeB - - - - - - - - - - - Lactamase_B k59_1722918_1 69395.JQLZ01000006_gene2286 4.52e-96 304.0 COG3451@1|root,COG3451@2|Bacteria,1MXH0@1224|Proteobacteria,2TR1U@28211|Alphaproteobacteria,2KEYI@204458|Caulobacterales 204458|Caulobacterales U Type VI secretion protein - - - ko:K03199 ko03070,map03070 M00333 - - ko00000,ko00001,ko00002,ko02044 3.A.7 - - CagE_TrbE_VirB k59_195668_1 338963.Pcar_1555 3.33e-101 328.0 COG0532@1|root,COG0532@2|Bacteria,1MV26@1224|Proteobacteria,42M5Q@68525|delta/epsilon subdivisions,2WIIX@28221|Deltaproteobacteria,43RX8@69541|Desulfuromonadales 28221|Deltaproteobacteria J Translation-initiation factor 2 infB - - ko:K02519 - - - - ko00000,ko03012,ko03029 - - - GTP_EFTU,IF-2,IF2_N k59_1610201_2 471857.Svir_20670 2.05e-17 81.3 COG1708@1|root,COG1708@2|Bacteria,2I8HB@201174|Actinobacteria,4E31Y@85010|Pseudonocardiales 201174|Actinobacteria S Domain of unknown function (DUF4111) - - 2.7.7.47 ko:K00984 - - - - ko00000,ko01000,ko01504 - - - DUF4111,NTP_transf_2 k59_1214219_1 98439.AJLL01000039_gene1855 8.5e-29 118.0 COG0006@1|root,COG0006@2|Bacteria,1G0KH@1117|Cyanobacteria,1JIC3@1189|Stigonemataceae 1117|Cyanobacteria E Aminopeptidase P, N-terminal domain pepP - 3.4.11.9 ko:K01262 - - - - ko00000,ko01000,ko01002 - - - AMP_N,Peptidase_M24 k59_876349_1 247639.MGP2080_02675 2.13e-24 104.0 COG2211@1|root,COG2211@2|Bacteria,1MVUM@1224|Proteobacteria,1RP5J@1236|Gammaproteobacteria 1236|Gammaproteobacteria G COG2211 Na melibiose symporter and related transporters - - - ko:K03292 - - - - ko00000 2.A.2 - - MFS_2 k59_1775935_1 1117647.M5M_12375 4.34e-55 184.0 COG0223@1|root,COG0223@2|Bacteria,1MU4Q@1224|Proteobacteria,1RP1T@1236|Gammaproteobacteria,1J4V0@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus fmt GO:0003674,GO:0003824,GO:0004479,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006413,GO:0006418,GO:0006431,GO:0006464,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016741,GO:0016742,GO:0019538,GO:0019752,GO:0019988,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036211,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071951,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 2.1.2.9 ko:K00604 ko00670,ko00970,map00670,map00970 - R03940 RC00026,RC00165 ko00000,ko00001,ko01000 - - iECABU_c1320.ECABU_c37050,iECUMN_1333.ECUMN_3761,ic_1306.c4048 Formyl_trans_C,Formyl_trans_N k59_592613_1 1129794.C427_5273 3.17e-112 336.0 COG0773@1|root,COG0773@2|Bacteria,1MUC5@1224|Proteobacteria,1RMMT@1236|Gammaproteobacteria,465PV@72275|Alteromonadaceae 1236|Gammaproteobacteria M Reutilizes the intact tripeptide L-alanyl-gamma-D- glutamyl-meso-diaminopimelate by linking it to UDP-N- acetylmuramate mpl GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0016874,GO:0016879,GO:0016881,GO:0042802,GO:0044424,GO:0044464 6.3.2.45 ko:K02558 - - - - ko00000,ko01000 - - iSDY_1059.SDY_4251 Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_195679_1 1120983.KB894572_gene2814 4.84e-73 240.0 COG4666@1|root,COG4666@2|Bacteria,1MUNB@1224|Proteobacteria,2TQY9@28211|Alphaproteobacteria 28211|Alphaproteobacteria S transport system fused permease components - - - - - - - - - - - - DctM k59_592617_1 533247.CRD_02200 4.85e-37 131.0 COG0778@1|root,COG0778@2|Bacteria,1G4SQ@1117|Cyanobacteria,1HQ49@1161|Nostocales 1117|Cyanobacteria C Nitroreductase family - - - - - - - - - - - - Nitroreductase k59_311148_1 1131266.ARWQ01000001_gene1349 2.07e-45 157.0 COG0462@1|root,arCOG00067@2157|Archaea,41SH1@651137|Thaumarchaeota 651137|Thaumarchaeota F Ribose-phosphate pyrophosphokinase - - 2.7.6.1 ko:K00948 ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230 M00005 R01049 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - Pribosyl_synth,Pribosyltran,Pribosyltran_N k59_477362_1 305900.GV64_13865 1.55e-45 148.0 COG0776@1|root,COG0776@2|Bacteria,1MZ5B@1224|Proteobacteria,1S8VH@1236|Gammaproteobacteria,1XKNG@135619|Oceanospirillales 135619|Oceanospirillales L Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions hupB - - ko:K03530 - - - - ko00000,ko03032,ko03036,ko03400 - - - Bac_DNA_binding k59_477362_2 203122.Sde_1610 6.56e-59 201.0 COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,1RPCB@1236|Gammaproteobacteria,464ZC@72275|Alteromonadaceae 1236|Gammaproteobacteria O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner lon GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0004175,GO:0004176,GO:0004252,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006515,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0009056,GO:0009057,GO:0009266,GO:0009314,GO:0009408,GO:0009628,GO:0009987,GO:0010165,GO:0010212,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0017171,GO:0019538,GO:0030163,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051603,GO:0070011,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575 3.4.21.53 ko:K01338 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - AAA,LON_substr_bdg,Lon_C k59_195691_1 207954.MED92_18038 3.66e-25 103.0 COG3165@1|root,COG3165@2|Bacteria,1R1CM@1224|Proteobacteria,1S1SM@1236|Gammaproteobacteria,1XKHK@135619|Oceanospirillales 135619|Oceanospirillales S SCP-2 sterol transfer family - - - ko:K03690 - - - - ko00000 - - - SCP2 k59_1610224_1 330214.NIDE3442 6.87e-64 208.0 COG3705@1|root,COG3705@2|Bacteria,3J13R@40117|Nitrospirae 40117|Nitrospirae E Histidyl-tRNA synthetase - - - ko:K02502 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R01071 RC02819,RC03200 ko00000,ko00001,ko00002 - - - tRNA-synt_His k59_929452_1 1178825.ALIH01000007_gene1631 9.11e-95 303.0 COG2982@1|root,COG2982@2|Bacteria,4NEJQ@976|Bacteroidetes,1HXHN@117743|Flavobacteriia 976|Bacteroidetes M membrane - - - - - - - - - - - - AsmA,AsmA_2 k59_311158_1 626887.J057_22855 1.65e-40 155.0 COG2203@1|root,COG4191@1|root,COG2203@2|Bacteria,COG4191@2|Bacteria,1MU55@1224|Proteobacteria,1RQ5N@1236|Gammaproteobacteria,4643T@72275|Alteromonadaceae 1236|Gammaproteobacteria T COG0642 Signal transduction histidine kinase prsK - - - - - - - - - - - GAF_2,HATPase_c k59_816208_1 926559.JoomaDRAFT_1169 4.09e-54 189.0 COG3507@1|root,COG3507@2|Bacteria,4NFXE@976|Bacteroidetes,1HZNM@117743|Flavobacteriia 976|Bacteroidetes G Belongs to the glycosyl hydrolase 43 family - - - - - - - - - - - - Glyco_hydro_43 k59_1268419_1 1227497.C491_03385 2.57e-36 146.0 arCOG02348@1|root,arCOG02350@1|root,arCOG02360@1|root,arCOG07605@1|root,arCOG02348@2157|Archaea,arCOG02350@2157|Archaea,arCOG02360@2157|Archaea,arCOG07605@2157|Archaea,2Y7VS@28890|Euryarchaeota,2410Y@183963|Halobacteria 183963|Halobacteria T GAF domain - - - - - - - - - - - - HATPase_c,HisKA,PAS_4 k59_1046096_1 1415778.JQMM01000001_gene1940 7.52e-85 272.0 COG0659@1|root,COG0659@2|Bacteria,1MVWV@1224|Proteobacteria,1RMCN@1236|Gammaproteobacteria,1J86M@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P STAS domain - - - ko:K03321 - - - - ko00000,ko02000 2.A.53.3 - - STAS,Sulfate_transp k59_1046097_1 469381.Dpep_1429 1.45e-41 147.0 COG3568@1|root,COG3568@2|Bacteria,3TC5E@508458|Synergistetes 508458|Synergistetes L Endonuclease Exonuclease phosphatase - - - - - - - - - - - - Exo_endo_phos k59_1046097_2 323098.Nwi_2993 4.62e-16 79.3 COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,2TS8E@28211|Alphaproteobacteria,3JSUZ@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria I enoyl-CoA hydratase isomerase MA20_44845 - 1.1.1.35,4.2.1.17,5.1.2.3,5.3.3.8 ko:K01782,ko:K01825 ko00071,ko00280,ko00281,ko00310,ko00362,ko00380,ko00410,ko00640,ko00650,ko00903,ko00930,ko01040,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00362,map00380,map00410,map00640,map00650,map00903,map00930,map01040,map01100,map01110,map01120,map01130,map01200,map01212 M00032,M00087 R01975,R03026,R03045,R03276,R04137,R04170,R04203,R04204,R04224,R04737,R04738,R04739,R04740,R04741,R04744,R04745,R04746,R04748,R04749,R04756,R05066,R05305,R06411,R06412,R06941,R06942,R07935,R07951,R08093,R08094 RC00029,RC00099,RC00117,RC00241,RC00525,RC00831,RC00834,RC00896,RC01078,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 - - - 3HCDH,3HCDH_N,ECH_1 k59_816215_1 1125863.JAFN01000001_gene114 2.21e-67 211.0 COG0664@1|root,COG0664@2|Bacteria,1MZZD@1224|Proteobacteria,42QUX@68525|delta/epsilon subdivisions,2WMWV@28221|Deltaproteobacteria 28221|Deltaproteobacteria K PFAM Cyclic nucleotide-binding fnr-1 - - ko:K01420,ko:K21563 - - - - ko00000,ko03000 - - - HTH_Crp_2,cNMP_binding k59_140936_1 1121374.KB891576_gene511 2.89e-20 87.8 28NHW@1|root,2ZBJG@2|Bacteria,1RBJB@1224|Proteobacteria,1S31B@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_140936_2 106370.Francci3_3380 2.33e-62 197.0 COG0602@1|root,COG0602@2|Bacteria,2I9R3@201174|Actinobacteria 201174|Actinobacteria H Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds queE - 4.3.99.3 ko:K10026 ko00790,ko01100,map00790,map01100 - R10002 RC02989 ko00000,ko00001,ko01000,ko03016 - - - Fer4_14,Radical_SAM k59_1384417_1 1451261.AS96_04820 4.23e-27 113.0 COG0661@1|root,COG0661@2|Bacteria,2GJQ6@201174|Actinobacteria,4FKT0@85023|Microbacteriaceae 201174|Actinobacteria S ABC1 family - - - - - - - - - - - - ABC1 k59_929465_1 247634.GPB2148_2636 1.51e-69 227.0 COG2303@1|root,COG2303@2|Bacteria,1MU3F@1224|Proteobacteria,1RPBQ@1236|Gammaproteobacteria,1J5ZV@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E COG2303 Choline dehydrogenase and related flavoproteins neoG - - - - - - - - - - - FAD_binding_2,GMC_oxred_C,GMC_oxred_N,NAD_binding_8 k59_1437710_1 1336233.JAEH01000016_gene3023 1.29e-15 71.6 COG0633@1|root,COG0633@2|Bacteria,1RHDC@1224|Proteobacteria,1S5XW@1236|Gammaproteobacteria,2QBX0@267890|Shewanellaceae 1236|Gammaproteobacteria C TIGRFAM ferredoxin, 2Fe-2S type, ISC system fdx - - ko:K04755 - - - - ko00000 - - - Fer2 k59_1437710_2 159450.NH14_21575 3.72e-28 102.0 COG2975@1|root,COG2975@2|Bacteria,1N7C1@1224|Proteobacteria,2VVQU@28216|Betaproteobacteria,1K9HY@119060|Burkholderiaceae 28216|Betaproteobacteria S Fe-S assembly protein IscX iscX - - - - - - - - - - - Fe-S_assembly k59_1437710_3 1121033.AUCF01000007_gene5882 2.92e-150 435.0 COG0119@1|root,COG0119@2|Bacteria,1MUNQ@1224|Proteobacteria,2TSCJ@28211|Alphaproteobacteria,2JQB8@204441|Rhodospirillales 204441|Rhodospirillales E Belongs to the alpha-IPM synthase homocitrate synthase family nifV - 2.3.3.14 ko:K02594 ko00620,map00620 - R00271 RC00004,RC00067,RC02754 ko00000,ko00001,ko01000 - - - HMGL-like k59_1384435_1 158500.BV97_04128 9.76e-90 269.0 COG1028@1|root,COG1028@2|Bacteria,1MUBQ@1224|Proteobacteria,2TRPN@28211|Alphaproteobacteria,2K13W@204457|Sphingomonadales 204457|Sphingomonadales IQ Belongs to the short-chain dehydrogenases reductases (SDR) family - - - - - - - - - - - - adh_short k59_1384435_2 1415756.JQMY01000001_gene781 3.84e-46 159.0 COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,2V8I8@28211|Alphaproteobacteria,2PFAX@252301|Oceanicola 28211|Alphaproteobacteria I Thiolase, C-terminal domain - - - - - - - - - - - - Thiolase_C,Thiolase_N k59_1723009_1 1122216.AUHW01000001_gene682 6.86e-07 55.8 COG0110@1|root,COG0110@2|Bacteria,1TQEX@1239|Firmicutes,4H4S1@909932|Negativicutes 909932|Negativicutes S Hexapeptide repeat of succinyl-transferase - - - - - - - - - - - - Hexapep,Mac k59_86818_2 525368.HMPREF0591_2927 3.26e-53 178.0 COG2141@1|root,COG2141@2|Bacteria,2GJRF@201174|Actinobacteria,2361K@1762|Mycobacteriaceae 201174|Actinobacteria C Catalyzes the reduction of the keto moiety of phthiodiolone dimycocerosates (DIM B) and glycosylated phenolphthiodiolone dimycocerosates to form the intermediate compounds phthiotriol and glycosylated phenolphthiotriol dimycocerosates during phthiocerol dimycocerosates (DIM A) and glycosylated phenolphthiocerol dimycocerosates (PGL) biosynthesis - - - ko:K14728 - - - - ko00000,ko01000 - - - Bac_luciferase k59_1611214_1 391626.OAN307_c11050 5.22e-75 238.0 COG0330@1|root,COG0330@2|Bacteria,1N5JY@1224|Proteobacteria,2TUCR@28211|Alphaproteobacteria 28211|Alphaproteobacteria O prohibitin homologues - - - - - - - - - - - - Band_7 k59_254498_1 1229909.NSED_07170 2.47e-76 229.0 COG1522@1|root,arCOG01580@2157|Archaea,41SNE@651137|Thaumarchaeota 651137|Thaumarchaeota K helix_turn_helix ASNC type - - - - - - - - - - - - AsnC_trans_reg,HTH_AsnC-type k59_254498_2 1229909.NSED_07165 1.98e-06 48.9 COG4992@1|root,arCOG00914@2157|Archaea,41SC8@651137|Thaumarchaeota 651137|Thaumarchaeota E Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family lysJ - - ko:K05830 ko00220,ko00300,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01130,map01210,map01230 M00031,M00763 R09778,R10932 RC00006,RC00062 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 k59_1100205_1 1122137.AQXF01000002_gene349 3.52e-246 700.0 COG1530@1|root,COG1530@2|Bacteria,1MV65@1224|Proteobacteria,2TRX2@28211|Alphaproteobacteria 28211|Alphaproteobacteria J Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs rne - 3.1.26.12 ko:K08300 ko03018,map03018 M00394 - - ko00000,ko00001,ko00002,ko01000,ko03009,ko03019 - - - RNase_E_G,S1 k59_1723887_1 1313172.YM304_29200 4.51e-58 198.0 COG1132@1|root,COG1132@2|Bacteria,2GITR@201174|Actinobacteria,4CNI7@84992|Acidimicrobiia 84992|Acidimicrobiia V ABC transporter transmembrane region - - - ko:K06147 - - - - ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran k59_986075_1 1265313.HRUBRA_01625 5.31e-87 281.0 COG0557@1|root,COG0557@2|Bacteria,1MUS6@1224|Proteobacteria,1RMQE@1236|Gammaproteobacteria,1J4SW@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs rnr GO:0000175,GO:0003674,GO:0003724,GO:0003824,GO:0004386,GO:0004518,GO:0004527,GO:0004532,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008408,GO:0008997,GO:0009056,GO:0009057,GO:0009266,GO:0009409,GO:0009628,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010605,GO:0010629,GO:0016070,GO:0016071,GO:0016462,GO:0016787,GO:0016788,GO:0016796,GO:0016817,GO:0016818,GO:0016896,GO:0017111,GO:0019222,GO:0019439,GO:0034458,GO:0034470,GO:0034641,GO:0034655,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0050896,GO:0060255,GO:0065007,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0140098,GO:1901360,GO:1901361,GO:1901575 - ko:K12573 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03016,ko03019 - - - HTH_12,OB_RNB,RNB,S1 k59_817179_1 1336237.JAEE01000002_gene1310 1.73e-42 145.0 COG2077@1|root,COG2077@2|Bacteria,1RAJ9@1224|Proteobacteria,1S263@1236|Gammaproteobacteria 1236|Gammaproteobacteria O Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides tpx GO:0003674,GO:0003824,GO:0004601,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008379,GO:0009636,GO:0009987,GO:0016209,GO:0016491,GO:0016667,GO:0016671,GO:0016684,GO:0032843,GO:0033554,GO:0034599,GO:0042221,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716,GO:0051920,GO:0055114,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1990748 1.11.1.15 ko:K11065 - - - - ko00000,ko01000 - - - Redoxin k59_817179_2 1123261.AXDW01000001_gene1495 9.34e-12 65.5 COG0403@1|root,COG0403@2|Bacteria,1MVC1@1224|Proteobacteria,1RPGZ@1236|Gammaproteobacteria,1X3XE@135614|Xanthomonadales 135614|Xanthomonadales E Glycine cleavage system P-protein - - 1.4.4.2 ko:K00282 ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200 - R01221,R03425 RC00022,RC00929,RC02834,RC02880 ko00000,ko00001,ko01000 - - - GDC-P k59_1611222_1 231434.JQJH01000027_gene1584 1.04e-63 214.0 COG1960@1|root,COG1960@2|Bacteria,1MU20@1224|Proteobacteria,2TQJS@28211|Alphaproteobacteria,3N9VZ@45404|Beijerinckiaceae 28211|Alphaproteobacteria I Acyl-CoA dehydrogenase type 2 domain - - 1.3.8.1 ko:K00248 ko00071,ko00280,ko00650,ko01100,ko01110,ko01120,ko01200,ko01212,map00071,map00280,map00650,map01100,map01110,map01120,map01200,map01212 - R01175,R01178,R02661,R03172,R04751 RC00052,RC00068,RC00076,RC00120,RC00148 ko00000,ko00001,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_C,Acyl-CoA_dh_M,Acyl-CoA_dh_N,AcylCoA_DH_N k59_1215419_2 1229909.NSED_06570 2.35e-11 63.2 COG1405@1|root,arCOG01981@2157|Archaea,41SXZ@651137|Thaumarchaeota 651137|Thaumarchaeota K Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB) - - - ko:K03124 ko03022,ko05169,ko05203,map03022,map05169,map05203 - - - ko00000,ko00001,ko03021 - - - TFIIB,TF_Zn_Ribbon k59_1665885_1 694569.D7S_01787 8.87e-40 149.0 COG0144@1|root,COG0223@1|root,COG0781@1|root,COG0144@2|Bacteria,COG0223@2|Bacteria,COG0781@2|Bacteria,1MWPE@1224|Proteobacteria,1RN8X@1236|Gammaproteobacteria,1Y781@135625|Pasteurellales 135625|Pasteurellales J Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA rsmB GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008173,GO:0008649,GO:0008757,GO:0009383,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.176 ko:K03500 - - - - ko00000,ko01000,ko03009 - - - Methyltr_RsmB-F,NusB k59_1555734_1 1265502.KB905934_gene3206 8.83e-07 48.9 COG1949@1|root,COG1949@2|Bacteria,1R9WX@1224|Proteobacteria,2VIA2@28216|Betaproteobacteria,4A9QS@80864|Comamonadaceae 28216|Betaproteobacteria L 3'-to-5' exoribonuclease specific for small oligoribonucleotides orn - - ko:K13288 ko03008,map03008 - - - ko00000,ko00001,ko01000,ko03009,ko03019 - - - RNase_T k59_1555734_2 644801.Psest_0485 3.58e-36 131.0 COG3577@1|root,COG3577@2|Bacteria,1N2PE@1224|Proteobacteria,1S60F@1236|Gammaproteobacteria,1Z1AK@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria S aspartyl protease orf - - ko:K06985 ko04112,map04112 - - - ko00000,ko00001 - - - gag-asp_proteas k59_196859_1 1122137.AQXF01000007_gene3490 7.65e-73 229.0 COG5330@1|root,COG5330@2|Bacteria 2|Bacteria K Evidence 4 Homologs of previously reported genes of - - - - - - - - - - - - DUF2336 k59_760526_1 436308.Nmar_0974 1.9e-38 135.0 COG1683@1|root,arCOG04848@2157|Archaea 2157|Archaea S Protein of unknown function (DUF1722) - - - - - - - - - - - - DUF1722,DUF523 k59_760526_2 1304885.AUEY01000046_gene7 1.43e-09 58.5 COG0415@1|root,COG0415@2|Bacteria,1MV9Y@1224|Proteobacteria,42MQ6@68525|delta/epsilon subdivisions,2WMJQ@28221|Deltaproteobacteria 28221|Deltaproteobacteria L FAD binding domain of DNA photolyase phr - 4.1.99.3 ko:K01669 - - - - ko00000,ko01000,ko03400 - - - DNA_photolyase,FAD_binding_7 k59_86850_1 1096930.L284_02310 7.14e-33 118.0 COG2001@1|root,COG2001@2|Bacteria,1RHCS@1224|Proteobacteria,2UJTK@28211|Alphaproteobacteria,2K6WD@204457|Sphingomonadales 204457|Sphingomonadales K Belongs to the MraZ family - - - ko:K03925 - - - - ko00000 - - - - k59_29739_1 1124983.PFLCHA0_c16240 2.29e-17 85.5 COG2207@1|root,COG2207@2|Bacteria,1R73I@1224|Proteobacteria,1SYD3@1236|Gammaproteobacteria,1YNSR@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria K Transcriptional regulator - - - - - - - - - - - - Arabinose_bd,HTH_18 k59_1100224_2 1517416.IDAT_10415 1.24e-61 215.0 COG1629@1|root,COG1629@2|Bacteria,COG4771@2|Bacteria,1MU9K@1224|Proteobacteria,1RMTG@1236|Gammaproteobacteria,2QFU2@267893|Idiomarinaceae 1236|Gammaproteobacteria M TonB-dependent Receptor - - - - - - - - - - - - Plug,TonB_dep_Rec k59_647909_1 903818.KI912268_gene1854 8.39e-35 138.0 28JHJ@1|root,2Z9B3@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_1499018_1 443598.AUFA01000094_gene6162 2.33e-100 309.0 COG3039@1|root,COG3039@2|Bacteria,1MVTU@1224|Proteobacteria,2TVIR@28211|Alphaproteobacteria,3JT6Q@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria L hmm pf01609 - - - ko:K07481 - - - - ko00000 - - - DDE_Tnp_1_6,DUF772 k59_533601_1 452637.Oter_0509 4.86e-58 196.0 COG1538@1|root,COG1538@2|Bacteria 2|Bacteria MU efflux transmembrane transporter activity - - - - - - - - - - - - OEP k59_647917_2 95619.PM1_0225890 1.14e-45 157.0 COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,1RW1Q@1236|Gammaproteobacteria 1236|Gammaproteobacteria I acyl-CoA dehydrogenase atuD - - ko:K11731 ko00281,map00281 - R08089 RC01893 ko00000,ko00001,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_877571_1 675812.VHA_001341 4.36e-85 272.0 COG0668@1|root,COG0668@2|Bacteria,1N596@1224|Proteobacteria,1RQZP@1236|Gammaproteobacteria,1XVNX@135623|Vibrionales 135623|Vibrionales M Small-conductance mechanosensitive channel - - - ko:K03442 - - - - ko00000,ko02000 1.A.23.2 - - MS_channel k59_312426_1 658187.LDG_5403 5.68e-10 55.5 COG1826@1|root,COG1826@2|Bacteria,1NGDP@1224|Proteobacteria,1T7EI@1236|Gammaproteobacteria,1JFA1@118969|Legionellales 118969|Legionellales U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system tatA - - ko:K03116 ko03060,ko03070,map03060,map03070 M00336 - - ko00000,ko00001,ko00002,ko02044 2.A.64 - - MttA_Hcf106 k59_312426_2 187272.Mlg_2618 1.23e-49 162.0 COG1490@1|root,COG1490@2|Bacteria,1RGTV@1224|Proteobacteria,1S61I@1236|Gammaproteobacteria,1WYB4@135613|Chromatiales 135613|Chromatiales J rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality dtd - - ko:K07560 - - - - ko00000,ko01000,ko03016 - - - Tyr_Deacylase k59_593869_1 1122137.AQXF01000003_gene2344 6.14e-121 357.0 COG3705@1|root,COG3705@2|Bacteria,1MWIG@1224|Proteobacteria,2TSVG@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine hisZ - - ko:K02502 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R01071 RC02819,RC03200 ko00000,ko00001,ko00002 - - - tRNA-synt_His k59_930313_1 1229780.BN381_30024 9.19e-99 305.0 COG0364@1|root,COG0364@2|Bacteria,2GISI@201174|Actinobacteria,3UW8Z@52018|unclassified Actinobacteria (class) 201174|Actinobacteria G Glucose-6-phosphate dehydrogenase, C-terminal domain zwf - 1.1.1.363,1.1.1.49 ko:K00036 ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230 M00004,M00006,M00008 R00835,R02736,R10907 RC00001,RC00066 ko00000,ko00001,ko00002,ko01000,ko04147 - - - G6PD_C,G6PD_N k59_1438586_1 56780.SYN_02631 1.13e-05 52.0 COG0668@1|root,COG0668@2|Bacteria,1N2GE@1224|Proteobacteria,42XYJ@68525|delta/epsilon subdivisions,2WSKT@28221|Deltaproteobacteria 28221|Deltaproteobacteria M PFAM Conserved TM helix repeat-containing protein - - - - - - - - - - - - TM_helix k59_94029_1 377629.TERTU_3934 3.56e-60 209.0 COG0823@1|root,COG0823@2|Bacteria,1R3VN@1224|Proteobacteria,1RNKG@1236|Gammaproteobacteria,2PN4G@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria U COG0823 Periplasmic component of the Tol biopolymer transport system - - - - - - - - - - - - PD40 k59_603086_1 1219035.NT2_05_03880 1.09e-40 137.0 COG0633@1|root,COG0633@2|Bacteria,1N261@1224|Proteobacteria,2UC7B@28211|Alphaproteobacteria,2K5DE@204457|Sphingomonadales 204457|Sphingomonadales C ferredoxin - - - ko:K04755 - - - - ko00000 - - - Fer2 k59_886369_1 1415778.JQMM01000001_gene1917 6.15e-116 342.0 COG4658@1|root,COG4658@2|Bacteria,1MVY6@1224|Proteobacteria,1T20Y@1236|Gammaproteobacteria,1JC0A@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol nqrB - 1.6.5.8 ko:K00347,ko:K03614 - - - - ko00000,ko01000 - - - NQR2_RnfD_RnfE k59_1564962_1 1144307.PMI04_03292 1e-07 52.4 COG4221@1|root,COG4221@2|Bacteria,1NR0X@1224|Proteobacteria,2UP15@28211|Alphaproteobacteria,2K5RB@204457|Sphingomonadales 204457|Sphingomonadales S Belongs to the short-chain dehydrogenases reductases (SDR) family - - - - - - - - - - - - adh_short k59_1564962_2 1123270.ATUR01000006_gene191 4.48e-81 248.0 2ADS9@1|root,313HS@2|Bacteria,1PSFQ@1224|Proteobacteria,2V4MP@28211|Alphaproteobacteria,2K8JT@204457|Sphingomonadales 204457|Sphingomonadales - - - - - - - - - - - - - - - k59_484765_1 1232443.BAIA02000004_gene626 5.5e-33 131.0 COG0008@1|root,COG0008@2|Bacteria,1TP8G@1239|Firmicutes,247Y0@186801|Clostridia,267XP@186813|unclassified Clostridiales 186801|Clostridia J tRNA synthetases class I (E and Q), anti-codon binding domain glnS - 6.1.1.18 ko:K01886 ko00970,ko01100,map00970,map01100 M00359,M00360 R03652 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_1c,tRNA-synt_1c_C k59_321597_1 436308.Nmar_1577 2.07e-152 442.0 COG0459@1|root,arCOG01257@2157|Archaea,41T11@651137|Thaumarchaeota 651137|Thaumarchaeota O TCP-1/cpn60 chaperonin family - - - ko:K22447 - - - - ko00000,ko03110 - - - Cpn60_TCP1 k59_321597_2 436308.Nmar_1576 3.96e-100 298.0 COG1940@1|root,arCOG04280@2157|Archaea,41SWX@651137|Thaumarchaeota 651137|Thaumarchaeota K ROK family - - 2.7.1.4 ko:K00847 ko00051,ko00500,ko00520,ko01100,map00051,map00500,map00520,map01100 - R00760,R00867,R03920 RC00002,RC00017 ko00000,ko00001,ko01000 - - - ROK k59_1275453_1 198214.SF2764 4.44e-112 329.0 COG0568@1|root,COG0568@2|Bacteria,1MUDI@1224|Proteobacteria,1RN8V@1236|Gammaproteobacteria 1236|Gammaproteobacteria K RNA polymerase sigma rpoS GO:0000988,GO:0000990,GO:0001000,GO:0001121,GO:0001123,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006351,GO:0006352,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0016987,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0019899,GO:0031323,GO:0031326,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043175,GO:0043254,GO:0044087,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0070063,GO:0071704,GO:0080090,GO:0090304,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901576,GO:1903506,GO:2000112,GO:2000142,GO:2001141 - ko:K03087 ko02026,ko05111,map02026,map05111 - - - ko00000,ko00001,ko03021 - - - Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4 k59_1275453_2 1440052.EAKF1_ch3252 7.77e-21 89.7 COG1388@1|root,COG4942@1|root,COG1388@2|Bacteria,COG4942@2|Bacteria,1RD24@1224|Proteobacteria,1RR11@1236|Gammaproteobacteria,3XP0U@561|Escherichia 1236|Gammaproteobacteria M autolysis nlpD GO:0000920,GO:0001896,GO:0005575,GO:0005623,GO:0008150,GO:0008219,GO:0009279,GO:0009987,GO:0012501,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0032153,GO:0042221,GO:0042493,GO:0043085,GO:0044093,GO:0044462,GO:0044464,GO:0050790,GO:0050896,GO:0051301,GO:0051336,GO:0051345,GO:0065007,GO:0065009,GO:0071944 - ko:K06194,ko:K12943 - - - - ko00000 1.A.34.1.2 - - LysM,Peptidase_M23 k59_148056_1 1415778.JQMM01000001_gene1901 2.67e-146 423.0 COG4651@1|root,COG4651@2|Bacteria,1QUQS@1224|Proteobacteria,1T21E@1236|Gammaproteobacteria,1J57I@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P Kef-type K transport kefC_1 - - - - - - - - - - - Na_H_Exchanger k59_377872_1 1122137.AQXF01000002_gene90 1.05e-175 500.0 COG1066@1|root,COG1066@2|Bacteria,1MUJQ@1224|Proteobacteria,2TS6F@28211|Alphaproteobacteria 28211|Alphaproteobacteria O DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function radA - - ko:K04485 - - - - ko00000,ko03400 - - - AAA_25,ATPase,ChlI k59_205799_1 574087.Acear_2126 2.69e-13 74.3 COG2244@1|root,COG2244@2|Bacteria,1TPSH@1239|Firmicutes,2492X@186801|Clostridia 186801|Clostridia S Polysaccharide biosynthesis protein - - - ko:K03328 - - - - ko00000 2.A.66.2 - - Polysacc_synt_3 k59_716020_1 305700.B447_11312 2.65e-71 229.0 COG2239@1|root,COG2239@2|Bacteria,1MW24@1224|Proteobacteria,2VI29@28216|Betaproteobacteria,2KUHE@206389|Rhodocyclales 206389|Rhodocyclales P Acts as a magnesium transporter mgtE - - ko:K06213 - - - - ko00000,ko02000 1.A.26.1 - - CBS,MgtE,MgtE_N k59_1394621_2 1122137.AQXF01000002_gene308 1.48e-82 249.0 COG0299@1|root,COG0299@2|Bacteria,1MWN1@1224|Proteobacteria,2TRY6@28211|Alphaproteobacteria 28211|Alphaproteobacteria F Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate purN GO:0003674,GO:0003824,GO:0004644,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0016740,GO:0016741,GO:0016742,GO:0033554,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716 2.1.2.2 ko:K11175 ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130 M00048 R04325,R04326 RC00026,RC00197,RC01128 ko00000,ko00001,ko00002,ko01000 - - - Formyl_trans_N,YjbR k59_94064_1 1229909.NSED_04810 1.54e-93 287.0 COG4962@1|root,arCOG01817@2157|Archaea,41T25@651137|Thaumarchaeota 651137|Thaumarchaeota N COG0630 Type IV secretory pathway, VirB11 components, and related ATPases involved in archaeal flagella biosynthesis - - - ko:K07332 - - - - ko00000,ko02035,ko02044 - - - T2SSE k59_1166311_1 309801.trd_1437 8.6e-24 98.6 COG1192@1|root,COG1192@2|Bacteria,2G62U@200795|Chloroflexi,27Y51@189775|Thermomicrobia 189775|Thermomicrobia D Anion-transporting ATPase - - - ko:K03496 - - - - ko00000,ko03036,ko04812 - - - AAA_31 k59_1166311_2 926569.ANT_13990 2.6e-30 115.0 COG0524@1|root,COG0524@2|Bacteria,2G6PQ@200795|Chloroflexi 200795|Chloroflexi G PFAM PfkB domain protein - - - - - - - - - - - - PfkB k59_1332523_1 941449.dsx2_3133 1.83e-41 155.0 COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,42MER@68525|delta/epsilon subdivisions,2WIYV@28221|Deltaproteobacteria,2MAGR@213115|Desulfovibrionales 28221|Deltaproteobacteria C xanthine dehydrogenase a b hammerhead - - 1.17.1.4 ko:K11177 ko00230,ko01100,ko01120,map00230,map01100,map01120 M00546 R01768,R02103 RC00143 ko00000,ko00001,ko00002,ko01000 - - - Ald_Xan_dh_C,Ald_Xan_dh_C2,Fer2_2 k59_1394628_1 1117315.AHCA01000024_gene1754 8.37e-16 80.5 COG3408@1|root,COG3408@2|Bacteria,1NJCP@1224|Proteobacteria,1RXM5@1236|Gammaproteobacteria 1236|Gammaproteobacteria G Bacterial alpha-L-rhamnosidase C-terminal domain - - 3.2.1.40 ko:K05989 - - - - ko00000,ko01000 - - - Bac_rhamnosid,Bac_rhamnosid6H,Bac_rhamnosid_C,Bac_rhamnosid_N k59_937265_1 1411685.U062_01902 4.9e-145 431.0 28HMZ@1|root,2Z7WD@2|Bacteria,1MU3Q@1224|Proteobacteria,1RRUM@1236|Gammaproteobacteria,1J7FC@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Protein of unknown function (DUF3604) - - - - - - - - - - - - DUF3604 k59_937265_2 1280944.HY17_09590 0.000533 42.0 COG0624@1|root,COG0624@2|Bacteria,1MWJS@1224|Proteobacteria,2TUHT@28211|Alphaproteobacteria 28211|Alphaproteobacteria E COG0624 Acetylornithine deacetylase Succinyl-diaminopimelate desuccinylase and related deacylases - - - - - - - - - - - - M20_dimer,Peptidase_M20,Peptidase_M28 k59_263078_1 436308.Nmar_0483 5.41e-81 247.0 COG1117@1|root,arCOG00231@2157|Archaea,41SYJ@651137|Thaumarchaeota 651137|Thaumarchaeota P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system pstB - 3.6.3.27 ko:K02036 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.7 - - ABC_tran k59_1507618_1 467661.RKLH11_3570 3.64e-165 486.0 COG2274@1|root,COG2274@2|Bacteria,1R2T0@1224|Proteobacteria,2USBQ@28211|Alphaproteobacteria 28211|Alphaproteobacteria V COG2274 ABC-type bacteriocin lantibiotic exporters, contain an N-terminal double-glycine peptidase domain hlyB - - ko:K06147,ko:K11004 ko02010,ko03070,ko05133,map02010,map03070,map05133 M00325,M00575 - - ko00000,ko00001,ko00002,ko02000,ko02044 3.A.1.106,3.A.1.109,3.A.1.109.1,3.A.1.109.2,3.A.1.21 - - ABC_membrane,ABC_tran,Peptidase_C39 k59_937274_1 426114.THI_1615 1.46e-85 278.0 COG0532@1|root,COG0532@2|Bacteria,1MV26@1224|Proteobacteria,2VK2H@28216|Betaproteobacteria,1KJJS@119065|unclassified Burkholderiales 28216|Betaproteobacteria J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex infB - - ko:K02519 - - - - ko00000,ko03012,ko03029 - - - GTP_EFTU,IF-2,IF2_N,IF2_assoc k59_263082_1 1005999.GLGR_2993 4.64e-38 143.0 28RV9@1|root,2ZE7I@2|Bacteria,1RCB8@1224|Proteobacteria,1S3ED@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - DUF3137 k59_38394_1 649638.Trad_1258 7.93e-78 240.0 COG0074@1|root,COG0074@2|Bacteria,1WJBR@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus C Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit sucD - 6.2.1.5 ko:K01902 ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374,M00620 R00405,R02404 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000 - - - CoA_binding,Ligase_CoA,Succ_CoA_lig k59_379042_1 999550.KI421507_gene453 5.32e-20 85.1 COG0848@1|root,COG0848@2|Bacteria,1MZ6M@1224|Proteobacteria,2UA46@28211|Alphaproteobacteria 28211|Alphaproteobacteria U biopolymer transport protein tolR - - ko:K03559,ko:K03560 - - - - ko00000,ko02000 1.A.30.2.1,1.A.30.2.2 - - ExbD k59_379042_2 1122137.AQXF01000003_gene2159 4.63e-60 191.0 COG0811@1|root,COG0811@2|Bacteria,1NCWW@1224|Proteobacteria,2TQXQ@28211|Alphaproteobacteria 28211|Alphaproteobacteria U MotA TolQ ExbB proton channel tolQ - - ko:K03562 ko01120,map01120 - - - ko00000,ko02000 1.A.30.2.2 - - MotA_ExbB k59_1447116_1 203908.EGF97968 1.07e-10 57.0 2CZUP@1|root,2SBR2@2759|Eukaryota,3ADX9@33154|Opisthokonta,3PHVZ@4751|Fungi 4751|Fungi - - - - - - - - - - - - - - - k59_264135_1 316067.Geob_2015 8.13e-17 87.0 COG1639@1|root,COG1639@2|Bacteria 2|Bacteria T HDOD domain - - - - - - - - - - - - DUF4388,HDOD k59_1731578_1 314287.GB2207_04722 1.24e-56 193.0 COG0062@1|root,COG0063@1|root,COG0062@2|Bacteria,COG0063@2|Bacteria,1MU1Q@1224|Proteobacteria,1RMPS@1236|Gammaproteobacteria,1J54X@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration nnrD GO:0003674,GO:0003824,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016854,GO:0052855,GO:0052856,GO:0052857 4.2.1.136,5.1.99.6 ko:K17758,ko:K17759 - - - - ko00000,ko01000 - - - Carb_kinase,YjeF_N k59_717312_1 1122137.AQXF01000006_gene896 4.99e-104 323.0 COG1629@1|root,COG4771@2|Bacteria,1MWKN@1224|Proteobacteria,2U10R@28211|Alphaproteobacteria 28211|Alphaproteobacteria P receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_717314_1 234267.Acid_3838 7.83e-19 90.9 COG0577@1|root,COG0577@2|Bacteria,3Y6B8@57723|Acidobacteria 57723|Acidobacteria V MacB-like periplasmic core domain - - - - - - - - - - - - FtsX,MacB_PCD k59_1619073_1 436308.Nmar_1627 0.0 890.0 COG0209@1|root,arCOG03713@1|root,arCOG03713@2157|Archaea,arCOG04276@2157|Archaea,41SAH@651137|Thaumarchaeota 651137|Thaumarchaeota F Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen - - 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - ATP-cone,Ribonuc_red_lgC,Ribonuc_red_lgN k59_768348_1 42565.FP66_13450 3.22e-60 206.0 COG1185@1|root,COG1185@2|Bacteria,1MVB9@1224|Proteobacteria,1RNBF@1236|Gammaproteobacteria,1XHJZ@135619|Oceanospirillales 135619|Oceanospirillales J Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction pnp - 2.7.7.8 ko:K00962 ko00230,ko00240,ko03018,map00230,map00240,map03018 M00394 R00437,R00438,R00439,R00440 RC02795 ko00000,ko00001,ko00002,ko01000,ko03016,ko03019 - - - KH_1,PNPase,RNase_PH,RNase_PH_C,S1 k59_887446_1 247634.GPB2148_1822 6.18e-68 224.0 COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,1RN3H@1236|Gammaproteobacteria 1236|Gammaproteobacteria KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance relA GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008728,GO:0008893,GO:0009116,GO:0009117,GO:0009119,GO:0009150,GO:0009259,GO:0009605,GO:0009987,GO:0009991,GO:0015949,GO:0015969,GO:0016020,GO:0016740,GO:0016772,GO:0016778,GO:0016787,GO:0016788,GO:0016794,GO:0019637,GO:0019693,GO:0030312,GO:0031667,GO:0033865,GO:0033875,GO:0034032,GO:0034035,GO:0034641,GO:0042278,GO:0042578,GO:0042594,GO:0044237,GO:0044238,GO:0044281,GO:0044464,GO:0046128,GO:0046483,GO:0050896,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:1901068,GO:1901135,GO:1901360,GO:1901564,GO:1901657 2.7.6.5 ko:K00951 ko00230,map00230 - R00429 RC00002,RC00078 ko00000,ko00001,ko01000 - - iSFV_1184.SFV_2673 ACT_4,HD_4,RelA_SpoT,TGS k59_264163_1 1123278.KB893554_gene3971 2.25e-39 137.0 COG4122@1|root,COG4122@2|Bacteria,4NGQ1@976|Bacteroidetes,47PD3@768503|Cytophagia 976|Bacteroidetes S Methyltransferase domain - - - - - - - - - - - - Methyltransf_24,Methyltransf_3 k59_149447_1 388051.AUFE01000018_gene233 1.11e-25 105.0 COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2VHFW@28216|Betaproteobacteria 28216|Betaproteobacteria C PFAM L-carnitine dehydratase bile acid-inducible protein F - - - - - - - - - - - - CoA_transf_3 k59_827218_1 391625.PPSIR1_41779 3.87e-21 99.0 COG3303@1|root,COG3303@2|Bacteria,1QX6Q@1224|Proteobacteria 1224|Proteobacteria C Cytochrome c554 and c-prime - - - - - - - - - - - - Cytochrom_C552,Cytochrome_C554,Paired_CXXCH_1 k59_887449_1 1123270.ATUR01000002_gene2636 9.46e-05 44.7 COG0795@1|root,COG0795@2|Bacteria,1MUF2@1224|Proteobacteria,2U55Q@28211|Alphaproteobacteria,2K07C@204457|Sphingomonadales 204457|Sphingomonadales S YjgP YjgQ family - - - ko:K07091 ko02010,map02010 M00320 - - ko00000,ko00001,ko00002,ko02000 1.B.42.1 - - YjgP_YjgQ k59_887449_2 1122137.AQXF01000006_gene857 8.21e-50 165.0 COG4704@1|root,COG4704@2|Bacteria,1REQD@1224|Proteobacteria,2U8UI@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Protein conserved in bacteria - - - - - - - - - - - - DUF2141 k59_1276685_2 1122604.JONR01000021_gene575 2.28e-24 100.0 COG1587@1|root,COG1587@2|Bacteria,1N93T@1224|Proteobacteria,1S367@1236|Gammaproteobacteria,1X75E@135614|Xanthomonadales 135614|Xanthomonadales H Uroporphyrinogen-III synthase HemD - - - - - - - - - - - - HEM4 k59_604261_1 316274.Haur_0429 2.97e-72 234.0 COG1274@1|root,COG1274@2|Bacteria,2G7VM@200795|Chloroflexi,374XU@32061|Chloroflexia 32061|Chloroflexia H Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle pckG - 4.1.1.32 ko:K01596 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko03320,ko04068,ko04151,ko04152,ko04910,ko04920,ko04922,ko04931,ko04964,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map03320,map04068,map04151,map04152,map04910,map04920,map04922,map04931,map04964 M00003 R00431,R00726 RC00002,RC02741 ko00000,ko00001,ko00002,ko01000 - - - PEPCK_C,PEPCK_N k59_604261_2 1122947.FR7_2190 8.49e-23 95.1 COG3861@1|root,COG3861@2|Bacteria,1V5R4@1239|Firmicutes 1239|Firmicutes S electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity - - - - - - - - - - - - PRC k59_1783566_1 391589.RGAI101_3935 2.1e-05 46.6 COG4424@1|root,COG4424@2|Bacteria,1N77D@1224|Proteobacteria,2TW4Z@28211|Alphaproteobacteria,2P3TN@2433|Roseobacter 28211|Alphaproteobacteria H Sulfotransferase domain - - - - - - - - - - - - Sulfotransfer_3 k59_1783566_2 631362.Thi970DRAFT_01138 2.03e-12 72.0 COG5360@1|root,COG5360@2|Bacteria,1MZ5X@1224|Proteobacteria,1T0KQ@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Heparinase II/III N-terminus - - - - - - - - - - - - Hepar_II_III,Hepar_II_III_N k59_1731608_1 269796.Rru_A1804 3.11e-27 115.0 COG0045@1|root,COG1042@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,1MW98@1224|Proteobacteria,2TR24@28211|Alphaproteobacteria,2JPV8@204441|Rhodospirillales 204441|Rhodospirillales C COG1042 Acyl-CoA synthetase (NDP forming) yfiQ - - ko:K09181 - - - - ko00000 - - - ATP-grasp_5,Acetyltransf_1,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig k59_1731608_2 196490.AUEZ01000021_gene773 1.84e-06 53.1 COG2079@1|root,COG2079@2|Bacteria,1MU3X@1224|Proteobacteria,2U4FQ@28211|Alphaproteobacteria,3K6HM@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S MmgE/PrpD family - - - - - - - - - - - - MmgE_PrpD k59_1673410_1 591157.SSLG_05744 0.000312 42.7 COG1123@1|root,COG4172@2|Bacteria,2H3HY@201174|Actinobacteria 201174|Actinobacteria O Belongs to the ABC transporter superfamily - - - ko:K02031,ko:K02032 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - ABC_tran,oligo_HPY k59_1673410_2 395019.Bmul_0839 4.7e-50 179.0 COG0609@1|root,COG0609@2|Bacteria,1MV9W@1224|Proteobacteria,2VK1S@28216|Betaproteobacteria,1K1E7@119060|Burkholderiaceae 28216|Betaproteobacteria P Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily btuC - - ko:K02015 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko02000 3.A.1.14 - - FecCD k59_1673410_3 1279038.KB907351_gene2824 9.44e-40 140.0 COG2087@1|root,COG2087@2|Bacteria,1RH0A@1224|Proteobacteria,2U98X@28211|Alphaproteobacteria,2JSPU@204441|Rhodospirillales 204441|Rhodospirillales H Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate cobU - 2.7.1.156,2.7.7.62 ko:K02231 ko00860,ko01100,map00860,map01100 M00122 R05221,R05222,R06558 RC00002,RC00428 ko00000,ko00001,ko00002,ko01000 - - - CobU k59_379071_1 903818.KI912268_gene2111 1.01e-67 217.0 COG0517@1|root,COG0517@2|Bacteria,3Y7MI@57723|Acidobacteria 57723|Acidobacteria S Putative transposase - - - - - - - - - - - - Y2_Tnp,Zn_Tnp_IS91 k59_379071_2 313595.P700755_001435 1.38e-08 56.6 COG4974@1|root,COG4974@2|Bacteria,4NGB5@976|Bacteroidetes,1HXP1@117743|Flavobacteriia,4C433@83612|Psychroflexus 976|Bacteroidetes L Site specific recombinase integrase - - - - - - - - - - - - Phage_integrase k59_39443_2 998674.ATTE01000001_gene2980 1.28e-22 100.0 COG0673@1|root,COG0673@2|Bacteria,1PFCP@1224|Proteobacteria,1RRTX@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Oxidoreductase family, NAD-binding Rossmann fold - - - - - - - - - - - - GFO_IDH_MocA k59_540939_1 290398.Csal_3112 7.55e-73 231.0 COG0019@1|root,COG0019@2|Bacteria,1MUA6@1224|Proteobacteria,1RMI2@1236|Gammaproteobacteria,1XHK6@135619|Oceanospirillales 135619|Oceanospirillales E Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine lysA - 4.1.1.20 ko:K01586 ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R00451 RC00299 ko00000,ko00001,ko00002,ko01000 - - - Orn_Arg_deC_N,Orn_DAP_Arg_deC k59_1508615_1 1122599.AUGR01000010_gene1060 2.57e-14 70.5 COG1309@1|root,COG1309@2|Bacteria,1MX72@1224|Proteobacteria,1RZBH@1236|Gammaproteobacteria,1XJWF@135619|Oceanospirillales 135619|Oceanospirillales K Repressor involved in choline regulation of the bet genes betI - - ko:K02167 - - - - ko00000,ko03000 - - - TetR_C_6,TetR_N k59_1508615_2 1122207.MUS1_06695 2.19e-49 171.0 COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,1RMBQ@1236|Gammaproteobacteria,1XIMQ@135619|Oceanospirillales 135619|Oceanospirillales C Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the reversible oxidation of betaine aldehyde to the corresponding acid betB - 1.2.1.8 ko:K00130 ko00260,ko01100,map00260,map01100 M00555 R02565,R02566 RC00080 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_656007_1 1137281.D778_00953 4.91e-97 305.0 COG0072@1|root,COG0073@1|root,COG0072@2|Bacteria,COG0073@2|Bacteria,4NF5B@976|Bacteroidetes,1HX4I@117743|Flavobacteriia 976|Bacteroidetes J Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily pheT GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016070,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494 6.1.1.20 ko:K01890 ko00970,map00970 M00359,M00360 R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - B3_4,B5,FDX-ACB,tRNA_bind k59_379075_1 196367.JNFG01000009_gene6338 2.95e-67 220.0 COG5421@1|root,COG5421@2|Bacteria,1R3NX@1224|Proteobacteria,2VNNI@28216|Betaproteobacteria,1K3QF@119060|Burkholderiaceae 28216|Betaproteobacteria L Transposase DDE domain - - - - - - - - - - - - DDE_Tnp_1 k59_1447150_1 1123253.AUBD01000009_gene2281 0.00097 48.9 COG3107@1|root,COG3107@2|Bacteria,1MUHR@1224|Proteobacteria,1RXX4@1236|Gammaproteobacteria,1X4TB@135614|Xanthomonadales 135614|Xanthomonadales M (Lipo)protein - - - ko:K07121 - - - - ko00000 - - - LppC k59_1223565_1 742723.HMPREF9477_00626 3.15e-37 149.0 COG0249@1|root,COG0249@2|Bacteria,1TPRJ@1239|Firmicutes,248GI@186801|Clostridia,27IUI@186928|unclassified Lachnospiraceae 186801|Clostridia L that it carries out the mismatch recognition step. This protein has a weak ATPase activity mutS - - ko:K03555 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V k59_1276702_1 748247.AZKH_0681 5.57e-57 184.0 COG3568@1|root,COG3568@2|Bacteria,1MVN7@1224|Proteobacteria,2VJYW@28216|Betaproteobacteria,2KV21@206389|Rhodocyclales 206389|Rhodocyclales L Endonuclease Exonuclease phosphatase - - - - - - - - - - - - Exo_endo_phos k59_1276702_2 1304883.KI912532_gene1500 2.47e-14 68.9 COG0494@1|root,COG0494@2|Bacteria,1RH6N@1224|Proteobacteria,2VR3U@28216|Betaproteobacteria,2KWKI@206389|Rhodocyclales 206389|Rhodocyclales L NUDIX domain - - 3.6.1.67 ko:K08310 ko00790,map00790 M00126 R04638 RC00002 ko00000,ko00001,ko00002,ko01000 - - - NUDIX k59_656011_1 1144305.PMI02_04764 1.6e-67 217.0 COG1289@1|root,COG1289@2|Bacteria,1PMRM@1224|Proteobacteria,2U2PT@28211|Alphaproteobacteria,2K31B@204457|Sphingomonadales 204457|Sphingomonadales S Fusaric acid resistance protein family - - - - - - - - - - - - FUSC_2 k59_1276705_1 1385515.N791_08305 1.24e-73 237.0 COG4805@1|root,COG4805@2|Bacteria,1MUBX@1224|Proteobacteria,1RMT7@1236|Gammaproteobacteria,1X4HY@135614|Xanthomonadales 135614|Xanthomonadales S protein conserved in bacteria - - - - - - - - - - - - DUF885 k59_1276705_2 1177181.T9A_00017 5.53e-38 134.0 2CD0I@1|root,32RWS@2|Bacteria,1N0MC@1224|Proteobacteria,1SABW@1236|Gammaproteobacteria,1XPPR@135619|Oceanospirillales 135619|Oceanospirillales S Domain of unknown function (DUF4399) - - - - - - - - - - - - DUF4399 k59_1276705_3 237609.PSAKL28_45280 1.47e-20 86.3 COG1047@1|root,COG1047@2|Bacteria,1RD35@1224|Proteobacteria,1S3QR@1236|Gammaproteobacteria 1236|Gammaproteobacteria G Peptidyl-prolyl cis-trans slyD GO:0000413,GO:0003674,GO:0003755,GO:0003824,GO:0005488,GO:0005507,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006464,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008270,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0010467,GO:0016151,GO:0016853,GO:0016859,GO:0018193,GO:0018208,GO:0019538,GO:0022417,GO:0031647,GO:0035821,GO:0036211,GO:0042026,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043963,GO:0044003,GO:0044068,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044403,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0044501,GO:0046872,GO:0046914,GO:0050821,GO:0050896,GO:0050897,GO:0051082,GO:0051604,GO:0051701,GO:0051704,GO:0051817,GO:0052027,GO:0052250,GO:0065007,GO:0065008,GO:0071704,GO:0140096,GO:1901564 5.2.1.8 ko:K03775 - - - - ko00000,ko01000,ko03110 - - - FKBP_C k59_264201_1 1219065.VPR01S_21_00620 1.53e-31 126.0 COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,1RN9T@1236|Gammaproteobacteria,1XSK2@135623|Vibrionales 135623|Vibrionales M Belongs to the peptidase S1C family degQ - 3.4.21.107 ko:K04771,ko:K04772 ko01503,ko02020,map01503,map02020 M00728 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 - - - PDZ,PDZ_2,Trypsin_2 k59_1055657_1 460265.Mnod_6253 8.33e-13 73.6 COG3567@1|root,COG3567@2|Bacteria,1QNPU@1224|Proteobacteria,2U19C@28211|Alphaproteobacteria 28211|Alphaproteobacteria S TIGRFAM phage-associated protein, HI1409 family - - - ko:K09961 - - - - ko00000 - - - DUF1073 k59_149491_1 316407.85675626 1.53e-72 218.0 COG2363@1|root,COG2363@2|Bacteria,1MZX3@1224|Proteobacteria,1SCNB@1236|Gammaproteobacteria,3XPMP@561|Escherichia 1236|Gammaproteobacteria S UPF0382 inner membrane protein YgdD ygdD GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - - - - - - - - - - DUF423 k59_149491_2 316407.85675625 7.25e-68 214.0 COG2933@1|root,COG2933@2|Bacteria,1MWBM@1224|Proteobacteria,1RMSB@1236|Gammaproteobacteria,3XM5R@561|Escherichia 1236|Gammaproteobacteria J Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily rlmM GO:0000154,GO:0000451,GO:0000453,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070677,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.186 ko:K06968 - - - - ko00000,ko01000,ko03009 - - - FtsJ k59_768402_1 765914.ThisiDRAFT_1913 1.09e-28 111.0 COG1077@1|root,COG1077@2|Bacteria,1MUMW@1224|Proteobacteria,1RN82@1236|Gammaproteobacteria,1WW91@135613|Chromatiales 135613|Chromatiales D TIGRFAM Cell shape determining protein MreB Mrl - - - ko:K03569 - - - - ko00000,ko02048,ko03036,ko04812 1.A.33.1,9.B.157.1 - - MreB_Mbl k59_725771_1 243090.RB8873 8.26e-09 62.8 COG0642@1|root,COG0745@1|root,COG2202@1|root,COG5278@1|root,COG0745@2|Bacteria,COG2202@2|Bacteria,COG2205@2|Bacteria,COG5278@2|Bacteria 2|Bacteria T phosphoserine phosphatase activity - - 2.1.1.80,2.7.13.3,3.1.1.61 ko:K03407,ko:K13924 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 - - - CHASE,CHASE3,CheB_methylest,CheR,CheR_N,GAF,HATPase_c,HisKA,Hpt,PAS,PAS_3,PAS_4,PAS_7,PAS_9,Response_reg,dCache_1 k59_1516964_1 316407.85676623 2.44e-69 230.0 COG2909@1|root,COG2909@2|Bacteria,1MVZZ@1224|Proteobacteria,1RN29@1236|Gammaproteobacteria,3XN8M@561|Escherichia 1236|Gammaproteobacteria K Positively regulates the transcription of the maltose regulon whose gene products are responsible for uptake and catabolism of malto-oligosaccharides. Binds and recognizes a DNA motif (called the malT box) 5'-GGA TG GA-3' malT GO:0003674,GO:0003700,GO:0005488,GO:0005515,GO:0005975,GO:0006355,GO:0008150,GO:0008152,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0030246,GO:0031323,GO:0031326,GO:0042802,GO:0044238,GO:0048031,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0070492,GO:0071704,GO:0080090,GO:0140110,GO:1903506,GO:2000112,GO:2001141 - ko:K03556 - - - - ko00000,ko03000 - - - AAA_16,GerE k59_895980_1 1088721.NSU_1743 3.14e-84 276.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2TQT0@28211|Alphaproteobacteria,2K0BI@204457|Sphingomonadales 204457|Sphingomonadales V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_157703_2 909663.KI867150_gene1576 7.69e-37 132.0 COG2043@1|root,COG2043@2|Bacteria,1R8EH@1224|Proteobacteria,42Q2F@68525|delta/epsilon subdivisions,2WJZN@28221|Deltaproteobacteria,2MQKY@213462|Syntrophobacterales 28221|Deltaproteobacteria S Uncharacterised ArCR, COG2043 - - - - - - - - - - - - DUF169 k59_725786_1 1122137.AQXF01000001_gene2726 1.08e-14 75.1 COG1506@1|root,COG1506@2|Bacteria,1MUJ3@1224|Proteobacteria,2U2CJ@28211|Alphaproteobacteria 28211|Alphaproteobacteria EU COG1506 Dipeptidyl aminopeptidases acylaminoacyl-peptidases - - - - - - - - - - - - PD40,Peptidase_S9 k59_1117529_1 323261.Noc_1696 9.78e-26 97.8 COG0780@1|root,COG0780@2|Bacteria,1MW0M@1224|Proteobacteria,1TJD2@1236|Gammaproteobacteria,1WYEP@135613|Chromatiales 135613|Chromatiales S Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) queF - 1.7.1.13 ko:K09457 ko00790,ko01100,map00790,map01100 - R07605 RC01875 ko00000,ko00001,ko01000,ko03016 - - - QueF k59_1117529_2 765914.ThisiDRAFT_2514 3.33e-41 150.0 COG1196@1|root,COG1196@2|Bacteria,1MUAQ@1224|Proteobacteria,1RNA6@1236|Gammaproteobacteria,1WW7V@135613|Chromatiales 135613|Chromatiales D Required for chromosome condensation and partitioning smc - - ko:K03529 - - - - ko00000,ko03036 - - - SMC_N,SMC_hinge k59_388481_1 864702.OsccyDRAFT_4705 1.99e-65 220.0 COG3174@1|root,COG3174@2|Bacteria,1G4HU@1117|Cyanobacteria 1117|Cyanobacteria S membrane - - - - - - - - - - - - DUF4010,MgtC k59_1792809_1 316407.21321977 4.69e-124 358.0 COG0774@1|root,COG0774@2|Bacteria,1MV6T@1224|Proteobacteria,1RQ72@1236|Gammaproteobacteria,3XP96@561|Escherichia 1236|Gammaproteobacteria M Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis lpxC GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008270,GO:0008610,GO:0008654,GO:0008759,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016787,GO:0016810,GO:0016811,GO:0019213,GO:0019637,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044464,GO:0046467,GO:0046493,GO:0046872,GO:0046914,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 3.5.1.108 ko:K02535 ko00540,ko01100,map00540,map01100 M00060 R04587 RC00166,RC00300 ko00000,ko00001,ko00002,ko01000,ko01005 - - iECS88_1305.ECS88_0100 LpxC k59_158551_1 265072.Mfla_2151 1.05e-46 162.0 COG1995@1|root,COG1995@2|Bacteria,1MX5W@1224|Proteobacteria,2VJN0@28216|Betaproteobacteria,2KKW8@206350|Nitrosomonadales 206350|Nitrosomonadales H Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) pdxA - 1.1.1.262 ko:K00097 ko00750,ko01100,map00750,map01100 M00124 R05681,R05837,R07406 RC00089,RC00675,RC01475 ko00000,ko00001,ko00002,ko01000 - - - PdxA k59_1064659_1 1158292.JPOE01000005_gene1203 6.78e-101 306.0 COG0056@1|root,COG0056@2|Bacteria,1MUG7@1224|Proteobacteria,2VHQU@28216|Betaproteobacteria,1KJ5T@119065|unclassified Burkholderiales 28216|Betaproteobacteria C Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit atpA - 3.6.3.14 ko:K02111 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - - ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N k59_1517916_1 1229909.NSED_05780 7.7e-75 236.0 COG0001@1|root,arCOG00918@2157|Archaea,41S5Y@651137|Thaumarchaeota 651137|Thaumarchaeota H Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family - - 5.4.3.8 ko:K01845 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R02272 RC00677 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 k59_1405373_1 1033802.SSPSH_002159 3.27e-39 141.0 COG0159@1|root,COG0159@2|Bacteria,1MXJV@1224|Proteobacteria,1RMGN@1236|Gammaproteobacteria 1236|Gammaproteobacteria E The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate trpA - 4.2.1.20 ko:K01695 ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230 M00023 R00674,R02340,R02722 RC00209,RC00210,RC00700,RC00701,RC02868 ko00000,ko00001,ko00002,ko01000 - - - Trp_syntA k59_947761_1 925775.XVE_3393 5.6e-13 66.6 COG2193@1|root,COG2193@2|Bacteria,1QU2D@1224|Proteobacteria,1T0QP@1236|Gammaproteobacteria,1XD19@135614|Xanthomonadales 135614|Xanthomonadales P Bacterioferritin - - 1.16.3.1 ko:K03594 ko00860,map00860 - R00078 RC02758 ko00000,ko00001,ko01000 - - - Ferritin k59_947761_3 1123072.AUDH01000017_gene2592 8.19e-05 44.7 COG0664@1|root,COG0664@2|Bacteria,1NCGM@1224|Proteobacteria,2UDQX@28211|Alphaproteobacteria,2JTVE@204441|Rhodospirillales 204441|Rhodospirillales T Cyclic nucleotide-binding domain - - - ko:K21563 - - - - ko00000,ko03000 - - - cNMP_binding k59_158592_1 983544.Lacal_1318 8.87e-68 206.0 COG3682@1|root,COG3682@2|Bacteria,4NNVM@976|Bacteroidetes,1I2YA@117743|Flavobacteriia 976|Bacteroidetes K transcriptional regulator - - - - - - - - - - - - Penicillinase_R k59_1456391_1 86416.Clopa_2341 1.02e-08 62.4 COG1074@1|root,COG1074@2|Bacteria,1TQ35@1239|Firmicutes,248ZF@186801|Clostridia,36E2W@31979|Clostridiaceae 186801|Clostridia L ATP-dependent helicase nuclease subunit A addA - 3.6.4.12 ko:K16898 - - - - ko00000,ko01000,ko03400 - - - PDDEXK_1,UvrD-helicase,UvrD_C k59_1740508_1 1279017.AQYJ01000028_gene2260 6.87e-47 171.0 COG1033@1|root,COG1033@2|Bacteria,1MUE1@1224|Proteobacteria,1RPIP@1236|Gammaproteobacteria,465BT@72275|Alteromonadaceae 1236|Gammaproteobacteria S exporters of the RND superfamily VP1286 - - ko:K07003 - - - - ko00000 - - - MMPL k59_104205_1 436308.Nmar_1443 1.85e-50 163.0 COG3794@1|root,arCOG02926@2157|Archaea,41TAN@651137|Thaumarchaeota 651137|Thaumarchaeota C Copper binding proteins, plastocyanin/azurin family - - - - - - - - - - - - Copper-bind k59_494962_1 566466.NOR53_2929 1.47e-74 243.0 COG0706@1|root,COG0706@2|Bacteria,1MV5M@1224|Proteobacteria,1RMH1@1236|Gammaproteobacteria,1J9G2@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins yidC GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006457,GO:0006810,GO:0008104,GO:0008150,GO:0008565,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0016043,GO:0022607,GO:0031224,GO:0031226,GO:0032977,GO:0033036,GO:0034613,GO:0042886,GO:0043933,GO:0044085,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051205,GO:0051234,GO:0051259,GO:0051260,GO:0051641,GO:0061024,GO:0065003,GO:0070727,GO:0071702,GO:0071705,GO:0071840,GO:0071944,GO:0072657,GO:0090150 - ko:K03217 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044,ko03029 2.A.9 - - 60KD_IMP,YidC_periplas k59_104206_1 436308.Nmar_1233 1.83e-67 208.0 COG1909@1|root,arCOG04076@2157|Archaea,41SNQ@651137|Thaumarchaeota 651137|Thaumarchaeota S Belongs to the UPF0218 family - - - ko:K09735 - - - - ko00000 - - - DUF359 k59_1405401_1 426114.THI_0122 1.91e-35 140.0 COG1452@1|root,COG1452@2|Bacteria,1MUJC@1224|Proteobacteria,2VIJ7@28216|Betaproteobacteria,1KJYE@119065|unclassified Burkholderiales 28216|Betaproteobacteria M Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane lptD - - ko:K04744 - - - - ko00000,ko02000 1.B.42.1 - - OstA,OstA_C k59_104211_2 436308.Nmar_0806 9.18e-47 152.0 COG0185@1|root,arCOG04099@2157|Archaea,41SMH@651137|Thaumarchaeota 651137|Thaumarchaeota J Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA rps19p - - ko:K02965 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S19 k59_836500_1 158500.BV97_00894 5.46e-98 300.0 COG0433@1|root,COG0433@2|Bacteria,1MUSH@1224|Proteobacteria,2TUN9@28211|Alphaproteobacteria,2K091@204457|Sphingomonadales 204457|Sphingomonadales S Domain of unknown function DUF87 - - - ko:K06915 - - - - ko00000 - - - DUF853,DUF87 k59_836502_1 1307759.JOMJ01000004_gene2450 1.66e-55 187.0 2DC6N@1|root,2ZD32@2|Bacteria,1Q0S4@1224|Proteobacteria,436UF@68525|delta/epsilon subdivisions,2X1IB@28221|Deltaproteobacteria,2MF4A@213115|Desulfovibrionales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_896982_1 1121904.ARBP01000007_gene3044 1.84e-51 169.0 COG2326@1|root,COG2326@2|Bacteria,4NFJ5@976|Bacteroidetes,47MY7@768503|Cytophagia 976|Bacteroidetes S Polyphosphate kinase 2 (PPK2) - - 2.7.4.1 ko:K22468 ko00190,ko03018,map00190,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - PPK2 k59_777132_1 99598.Cal7507_4921 3.85e-41 155.0 COG0745@1|root,COG2198@1|root,COG2199@1|root,COG2204@1|root,COG3437@1|root,COG5002@1|root,COG0745@2|Bacteria,COG2198@2|Bacteria,COG2204@2|Bacteria,COG3437@2|Bacteria,COG3706@2|Bacteria,COG5002@2|Bacteria,1G027@1117|Cyanobacteria,1HKPC@1161|Nostocales 1117|Cyanobacteria T COGs COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain - - - - - - - - - - - - GAF_2,GGDEF,HATPase_c,HisKA,Hpt,PAS_3,PAS_9,Response_reg,Trans_reg_C k59_104216_1 1057002.KB905370_gene4613 2.32e-24 107.0 COG0457@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2TRUI@28211|Alphaproteobacteria,4B9BA@82115|Rhizobiaceae 28211|Alphaproteobacteria T Adenylate cyclase - - - - - - - - - - - - Guanylate_cyc,TPR_16,TPR_2,TPR_8 k59_1117610_1 1122603.ATVI01000005_gene3679 1.28e-154 449.0 COG1003@1|root,COG1003@2|Bacteria,1MUDP@1224|Proteobacteria,1RND3@1236|Gammaproteobacteria,1X35C@135614|Xanthomonadales 135614|Xanthomonadales E The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor gcvP - 1.4.4.2 ko:K00281,ko:K00283 ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200 M00532 R01221,R03425 RC00022,RC00929,RC02834,RC02880 ko00000,ko00001,ko00002,ko01000 - - - GDC-P k59_1575361_1 1072685.IX83_08030 7.97e-45 156.0 COG0331@1|root,COG0331@2|Bacteria,1MV6N@1224|Proteobacteria,2VJF7@28216|Betaproteobacteria,3T1JV@506|Alcaligenaceae 28216|Betaproteobacteria I Malonyl CoA-acyl carrier protein transacylase fabD GO:0003674,GO:0003824,GO:0004312,GO:0004314,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016417,GO:0016419,GO:0016420,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0072330,GO:1901576 2.3.1.39 ko:K00645,ko:K15355 ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212 M00082 R01626,R11671 RC00004,RC00039,RC02727 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Acyl_transf_1 k59_48224_1 670307.HYPDE_33203 6.27e-57 189.0 COG1752@1|root,COG1752@2|Bacteria,1MVHW@1224|Proteobacteria,2TS4V@28211|Alphaproteobacteria 28211|Alphaproteobacteria S esterase of the alpha-beta hydrolase superfamily - - - ko:K07001 - - - - ko00000 - - - Patatin k59_273891_2 1298608.JCM18900_11088 4.39e-12 65.1 COG1690@1|root,COG1690@2|Bacteria,1MUHA@1224|Proteobacteria,1RMXH@1236|Gammaproteobacteria,3NJQZ@468|Moraxellaceae 1236|Gammaproteobacteria S tRNA-splicing ligase RtcB rtcB - 6.5.1.3 ko:K14415 - - - - ko00000,ko01000,ko03016 - - - RtcB k59_777150_1 153948.NAL212_1200 7.52e-23 99.0 COG0471@1|root,COG0471@2|Bacteria,1MU0K@1224|Proteobacteria,2VP0G@28216|Betaproteobacteria 28216|Betaproteobacteria P COG0471 Di- and tricarboxylate transporters - - - - - - - - - - - - CitMHS,Na_sulph_symp,TrkA_C k59_104229_1 1463854.JOHT01000009_gene1326 2.39e-15 76.3 COG1021@1|root,COG1021@2|Bacteria,2I2IR@201174|Actinobacteria 201174|Actinobacteria Q PFAM AMP-dependent synthetase and ligase - - 2.7.7.58,6.3.2.14 ko:K02363 ko01053,ko01110,ko01130,map01053,map01110,map01130 - R07644 RC00162,RC03046 ko00000,ko00001,ko01000,ko01008 - - - AMP-binding,AMP-binding_C k59_104229_2 218491.ECA0477 2.76e-49 168.0 COG1169@1|root,COG1169@2|Bacteria,1MVB7@1224|Proteobacteria,1RRBX@1236|Gammaproteobacteria,1MRHS@122277|Pectobacterium 1236|Gammaproteobacteria HQ Isochorismate synthase entC GO:0003674,GO:0003824,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008909,GO:0009058,GO:0009237,GO:0009987,GO:0016853,GO:0016866,GO:0019184,GO:0019290,GO:0019748,GO:0034641,GO:0043043,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044550,GO:0050486,GO:0051186,GO:0051188,GO:0071704,GO:1901564,GO:1901566,GO:1901576 5.4.4.2 ko:K01851,ko:K02361 ko00130,ko01053,ko01100,ko01110,ko01130,map00130,map01053,map01100,map01110,map01130 M00116 R01717 RC00588 ko00000,ko00001,ko00002,ko01000 - - - Chorismate_bind k59_726922_1 1247963.JPHU01000002_gene2658 1.76e-125 377.0 COG4770@1|root,COG4770@2|Bacteria,1P6RE@1224|Proteobacteria,2TRC2@28211|Alphaproteobacteria 28211|Alphaproteobacteria I Acetyl propionyl-CoA carboxylase alpha subunit MA20_30205 - 6.4.1.4 ko:K01968 ko00280,ko01100,map00280,map01100 M00036 R04138 RC00367,RC00942 ko00000,ko00001,ko00002,ko01000 - - - Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2 k59_494980_1 391937.NA2_13180 5.91e-15 80.1 COG0470@1|root,COG0470@2|Bacteria,1MY1W@1224|Proteobacteria,2TV3E@28211|Alphaproteobacteria,43H53@69277|Phyllobacteriaceae 28211|Alphaproteobacteria L DNA polymerase III holB - 2.7.7.7 ko:K02341 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_delta2 k59_777160_1 656024.FsymDg_3631 5.73e-15 75.5 COG0289@1|root,COG0289@2|Bacteria,2GM2T@201174|Actinobacteria,4ERHD@85013|Frankiales 201174|Actinobacteria E Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate dapB GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008839,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016020,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0019752,GO:0019877,GO:0030312,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0048037,GO:0050661,GO:0050662,GO:0051287,GO:0055114,GO:0070402,GO:0070404,GO:0071704,GO:0071944,GO:0097159,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.17.1.8 ko:K00215 ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R04198,R04199 RC00478 ko00000,ko00001,ko00002,ko01000 - - iNJ661.Rv2773c DapB_C,DapB_N k59_777160_2 1123320.KB889675_gene4004 2.75e-18 85.9 COG0612@1|root,COG0612@2|Bacteria,2GJZ3@201174|Actinobacteria 201174|Actinobacteria S Belongs to the peptidase M16 family pepR GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - - - - - - - - - - Peptidase_M16,Peptidase_M16_C k59_1405448_1 1122137.AQXF01000006_gene923 4.05e-23 98.2 COG0834@1|root,COG0834@2|Bacteria 2|Bacteria ET amino acid transport - - 2.7.13.3 ko:K02030,ko:K07679 ko02020,ko05133,map02020,map05133 M00236,M00477 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02000,ko02022 3.A.1.3 - - SBP_bac_3 k59_836559_1 1385517.N800_04425 5.33e-11 67.0 COG1596@1|root,COG1596@2|Bacteria,1N7GP@1224|Proteobacteria,1RQSM@1236|Gammaproteobacteria,1X7BN@135614|Xanthomonadales 135614|Xanthomonadales M Polysaccharide biosynthesis/export protein - - - - - - - - - - - - Poly_export,SLBB k59_1117632_1 511062.GU3_11510 5.16e-38 130.0 COG0718@1|root,COG0718@2|Bacteria,1RGZD@1224|Proteobacteria,1S5WU@1236|Gammaproteobacteria,1Y4H5@135624|Aeromonadales 135624|Aeromonadales L Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection - - - ko:K09747 - - - - ko00000 - - - YbaB_DNA_bd k59_1117632_2 1134474.O59_001928 2.42e-13 71.6 COG2812@1|root,COG2812@2|Bacteria,1MVCK@1224|Proteobacteria,1RMIA@1236|Gammaproteobacteria,1FH14@10|Cellvibrio 1236|Gammaproteobacteria L DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity dnaX GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030234,GO:0030337,GO:0032991,GO:0034641,GO:0034645,GO:0042575,GO:0042802,GO:0043170,GO:0043846,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050790,GO:0061695,GO:0065007,GO:0065009,GO:0071704,GO:0090304,GO:0098772,GO:1901360,GO:1901576,GO:1902494,GO:1990234 2.7.7.7 ko:K02343 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_delta2,DNA_pol3_gamma3,DNA_pol3_tau_4,DNA_pol3_tau_5 k59_1683411_1 1122137.AQXF01000005_gene1249 1.11e-111 347.0 COG3383@1|root,COG3383@2|Bacteria,1QTZB@1224|Proteobacteria,2TVZI@28211|Alphaproteobacteria 28211|Alphaproteobacteria C Formate dehydrogenase, alpha subunit - - 1.17.1.9 ko:K00123 ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200 - R00519 RC02796 ko00000,ko00001,ko01000 - - - Fer2_4,Fer4,Fer4_6,Fer4_7,Fer4_9,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3 k59_1683411_2 463191.SSEG_10289 3.52e-75 241.0 COG1894@1|root,COG1894@2|Bacteria,2GMMC@201174|Actinobacteria 201174|Actinobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain - - - ko:K00124 ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200 - R00519 RC02796 ko00000,ko00001 - - - 2Fe-2S_thioredx,Complex1_51K,NADH_4Fe-4S,SLBB k59_48250_1 1122137.AQXF01000001_gene3173 8.52e-158 445.0 COG1137@1|root,COG1137@2|Bacteria,1MU8M@1224|Proteobacteria,2TR7F@28211|Alphaproteobacteria 28211|Alphaproteobacteria S ABC transporter, (ATP-binding protein) lptB - - ko:K06861 ko02010,map02010 M00320 - - ko00000,ko00001,ko00002,ko01000,ko02000 1.B.42.1 - - ABC_tran,BCA_ABC_TP_C k59_48250_2 1122137.AQXF01000001_gene3174 1.08e-20 91.7 COG1508@1|root,COG1508@2|Bacteria,1MW4V@1224|Proteobacteria,2TS41@28211|Alphaproteobacteria 28211|Alphaproteobacteria K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released rpoN - - ko:K03092 ko02020,ko05111,map02020,map05111 - - - ko00000,ko00001,ko03021 - - - Sigma54_AID,Sigma54_CBD,Sigma54_DBD k59_665913_2 247634.GPB2148_227 4.7e-40 139.0 COG5514@1|root,COG5514@2|Bacteria,1MX90@1224|Proteobacteria,1S9SH@1236|Gammaproteobacteria,1JAEA@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Domain of unknown function (DUF1794) - - - - - - - - - - - - DUF1794 k59_331626_1 946483.Cenrod_1394 3.8e-26 117.0 COG1345@1|root,COG1345@2|Bacteria,1MUVP@1224|Proteobacteria,2VHMK@28216|Betaproteobacteria,4AB3F@80864|Comamonadaceae 28216|Betaproteobacteria N Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end fliD - - ko:K02407 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - Flagellin_IN,FliD_C,FliD_N k59_1683418_1 926569.ANT_12410 2.72e-101 303.0 COG0189@1|root,COG0189@2|Bacteria,2G5RN@200795|Chloroflexi 200795|Chloroflexi HJ Belongs to the RimK family - - 6.3.2.43 ko:K05827 ko00300,ko01100,ko01210,ko01230,map00300,map01100,map01210,map01230 M00031 R09775 RC00064,RC00090 ko00000,ko00001,ko00002,ko01000 - - - RimK k59_1628113_1 1123228.AUIH01000002_gene1534 2.95e-41 148.0 COG0206@1|root,COG0206@2|Bacteria,1MV2X@1224|Proteobacteria,1RPZS@1236|Gammaproteobacteria,1XIF2@135619|Oceanospirillales 135619|Oceanospirillales D Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity ftsZ - - ko:K03531 ko04112,map04112 - - - ko00000,ko00001,ko02048,ko03036,ko04812 - - - FtsZ_C,Tubulin k59_777184_1 931627.MycrhDRAFT_0068 1.16e-10 63.9 COG5517@1|root,COG5517@2|Bacteria,2GR5G@201174|Actinobacteria,23BED@1762|Mycobacteriaceae 201174|Actinobacteria Q SnoaL-like domain - - - - - - - - - - - - SnoaL_4 k59_495007_1 316407.1651595 4.05e-107 323.0 COG1626@1|root,COG1626@2|Bacteria,1MWSM@1224|Proteobacteria,1RMFP@1236|Gammaproteobacteria,3XMWX@561|Escherichia 1236|Gammaproteobacteria G Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system treA GO:0003674,GO:0003824,GO:0004553,GO:0004555,GO:0005575,GO:0005623,GO:0005975,GO:0005984,GO:0005991,GO:0005993,GO:0006950,GO:0006970,GO:0006972,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009311,GO:0009313,GO:0009628,GO:0009987,GO:0015927,GO:0016052,GO:0016787,GO:0016798,GO:0030288,GO:0030313,GO:0031975,GO:0033554,GO:0042597,GO:0044237,GO:0044238,GO:0044248,GO:0044262,GO:0044275,GO:0044464,GO:0046352,GO:0050896,GO:0051716,GO:0071214,GO:0071470,GO:0071474,GO:0071704,GO:0104004,GO:1901575 3.2.1.28 ko:K01194 ko00500,ko01100,map00500,map01100 - R00010 RC00049 ko00000,ko00001,ko00537,ko01000 - GH37 iAF1260.b1197,iB21_1397.B21_01182,iBWG_1329.BWG_1022,iECBD_1354.ECBD_2425,iECB_1328.ECB_01172,iECDH10B_1368.ECDH10B_1250,iECDH1ME8569_1439.ECDH1ME8569_1136,iECD_1391.ECD_01172,iECUMN_1333.ECUMN_1493,iETEC_1333.ETEC_1301,iEcDH1_1363.EcDH1_2451,iEcHS_1320.EcHS_A1301,iEcolC_1368.EcolC_2429,iJO1366.b1197,iJR904.b1197,iSBO_1134.SBO_3518,iY75_1357.Y75_RS06245 Trehalase k59_495007_2 316407.85674872 3.05e-77 242.0 COG1080@1|root,COG1925@1|root,COG3412@1|root,COG1080@2|Bacteria,COG1925@2|Bacteria,COG3412@2|Bacteria,1MUT8@1224|Proteobacteria,1RRCZ@1236|Gammaproteobacteria,3XN0F@561|Escherichia 1236|Gammaproteobacteria G Protein deacetylase that removes acetyl groups on specific lysine residues in target proteins. Regulates transcription by catalyzing deacetylation of 'Lys-52' and 'Lys-62' of the transcriptional repressor RutR. Is also able to deacetylate NhoA and RluC in vitro. Targets a distinct set of substrates compared to CobB dhaM GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006476,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016787,GO:0018193,GO:0018205,GO:0019213,GO:0019538,GO:0033554,GO:0033558,GO:0034983,GO:0035601,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0047324,GO:0050896,GO:0051716,GO:0071704,GO:0098732,GO:0140096,GO:1901564 2.7.1.121 ko:K05881 ko00561,map00561 - R01012 RC00015,RC00017 ko00000,ko00001,ko01000,ko02000 - - iECs_1301.ECs1703,iSF_1195.SF1201,iS_1188.S1285,iUTI89_1310.UTI89_C1391,iZ_1308.Z1969 EIIA-man,PEP-utilisers_N,PEP-utilizers,PTS-HPr k59_836574_2 436308.Nmar_0549 7.18e-147 420.0 COG1685@1|root,arCOG01025@2157|Archaea,41SGZ@651137|Thaumarchaeota 651137|Thaumarchaeota E GHMP kinases N terminal domain aroK - 2.7.1.71 ko:K00891 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02412 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - GHMP_kinases_C,GHMP_kinases_N k59_836574_3 436308.Nmar_0550 1.68e-104 308.0 COG0169@1|root,arCOG01033@2157|Archaea,41S6G@651137|Thaumarchaeota 651137|Thaumarchaeota E Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) aroE - 1.1.1.25 ko:K00014 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02413 RC00206 ko00000,ko00001,ko00002,ko01000 - - - Shikimate_DH,Shikimate_dh_N k59_1456478_1 909663.KI867150_gene213 7.08e-46 167.0 COG0457@1|root,COG0457@2|Bacteria,1NNJ6@1224|Proteobacteria,42PBD@68525|delta/epsilon subdivisions,2WKWJ@28221|Deltaproteobacteria,2MRCI@213462|Syntrophobacterales 28221|Deltaproteobacteria M PFAM Tetratricopeptide repeat - - - - - - - - - - - - PMT_2,TPR_1,TPR_11,TPR_16,TPR_17,TPR_2,TPR_8 k59_331639_1 398767.Glov_1281 1.17e-16 84.3 COG1450@1|root,COG1450@2|Bacteria,1MUUA@1224|Proteobacteria,42M9I@68525|delta/epsilon subdivisions,2WK1H@28221|Deltaproteobacteria 28221|Deltaproteobacteria NU Type II and III secretion system protein gspD - - ko:K02453 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - Secretin,Secretin_N k59_439549_1 911045.PSE_3368 1.86e-77 248.0 COG1232@1|root,COG1232@2|Bacteria,1MX35@1224|Proteobacteria,2TU7I@28211|Alphaproteobacteria 28211|Alphaproteobacteria H amine oxidase - - - - - - - - - - - - Amino_oxidase k59_1575426_1 713587.THITH_01770 1.63e-81 268.0 COG0209@1|root,COG1372@1|root,COG0209@2|Bacteria,COG1372@2|Bacteria,1MUJ8@1224|Proteobacteria,1RQUR@1236|Gammaproteobacteria,1WW7J@135613|Chromatiales 135613|Chromatiales F Ribonucleotide reductase, barrel domain - - 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - Intein_splicing,LAGLIDADG_3,Ribonuc_red_lgC,Ribonuc_red_lgN k59_215916_2 1276227.SCHRY_v1c03710 4.22e-08 55.5 COG1428@1|root,COG1428@2|Bacteria,3WT89@544448|Tenericutes 544448|Tenericutes F Deoxynucleoside kinase dck - 2.7.1.74,2.7.1.76 ko:K15519 ko00230,ko00240,ko01100,map00230,map00240,map01100 - R00185,R01666,R02089 RC00002,RC00017 ko00000,ko00001,ko01000 - - - dNK k59_388616_1 1229780.BN381_450015 2.18e-15 79.7 COG2010@1|root,COG2010@2|Bacteria,2H5KX@201174|Actinobacteria 201174|Actinobacteria C Cytochrome c - - - - - - - - - - - - - k59_1575427_1 1122137.AQXF01000003_gene2324 3.14e-101 316.0 COG0751@1|root,COG0751@2|Bacteria,1MV2F@1224|Proteobacteria,2TQKJ@28211|Alphaproteobacteria 28211|Alphaproteobacteria J Glycyl-tRNA synthetase beta subunit glyS - 6.1.1.14 ko:K01879 ko00970,map00970 M00360 R03654 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DALR_1,tRNA_synt_2f k59_665942_1 1120998.AUFC01000001_gene1968 1.81e-46 157.0 COG4887@1|root,COG4887@2|Bacteria,1V4ZU@1239|Firmicutes,24CCD@186801|Clostridia 186801|Clostridia C Psort location Cytoplasmic, score - - - - - - - - - - - - DUF1847 k59_388629_1 1515746.HR45_07875 9.22e-91 271.0 COG2259@1|root,COG2259@2|Bacteria,1RBZP@1224|Proteobacteria,1S28E@1236|Gammaproteobacteria,2Q9UR@267890|Shewanellaceae 1236|Gammaproteobacteria S PFAM DoxX family protein - - - - - - - - - - - - DoxX k59_439554_2 1298867.AUES01000001_gene1805 5.27e-54 180.0 COG4948@1|root,COG4948@2|Bacteria,1MURK@1224|Proteobacteria,2U10C@28211|Alphaproteobacteria,3JR02@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria M Mandelate racemase / muconate lactonizing enzyme, N-terminal domain - - - - - - - - - - - - MR_MLE_C,MR_MLE_N k59_158695_1 436308.Nmar_0299 1.02e-192 546.0 COG0036@1|root,COG3959@1|root,arCOG01053@2157|Archaea,arCOG05046@2157|Archaea,41SBE@651137|Thaumarchaeota 651137|Thaumarchaeota G Transketolase, thiamine diphosphate binding domain - - 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 - - - Ribul_P_3_epim,Transketolase_N k59_1518010_1 631454.N177_3989 4.57e-17 86.7 COG4993@1|root,COG4993@2|Bacteria,1MUQX@1224|Proteobacteria,2TQMV@28211|Alphaproteobacteria,1JPPK@119043|Rhodobiaceae 28211|Alphaproteobacteria G PQQ enzyme repeat - - 1.1.5.2 ko:K00117 ko00030,ko01100,ko01110,ko01130,map00030,map01100,map01110,map01130 - R06620 RC00066 ko00000,ko00001,ko01000 - - - PQQ,PQQ_2 k59_613720_1 436308.Nmar_1704 3.05e-60 187.0 arCOG08775@1|root,arCOG08775@2157|Archaea,41T9K@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1405479_2 247633.GP2143_15941 5.47e-22 92.4 COG1392@1|root,COG1392@2|Bacteria,1MXY9@1224|Proteobacteria,1RQHT@1236|Gammaproteobacteria,1J5PM@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P COG1392 Phosphate transport regulator (distant homolog of PhoU) UF78_21250 - - ko:K07220 - - - - ko00000 - - - PhoU_div k59_1740594_1 316407.85675741 1.12e-150 428.0 COG1494@1|root,COG1494@2|Bacteria,1R5BK@1224|Proteobacteria,1S16G@1236|Gammaproteobacteria,3XPBC@561|Escherichia 1236|Gammaproteobacteria G Catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate. Also displays a low activity toward glucose 1,6-bisphosphate, and no activity against ribulose 1,5- bisphosphate, fructose 2,6-bisphosphate, or fructose 1-phosphate yggF GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006094,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016051,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019203,GO:0019318,GO:0019319,GO:0019637,GO:0030145,GO:0030388,GO:0042132,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046364,GO:0046872,GO:0046914,GO:0050308,GO:0071704,GO:1901135,GO:1901576 - - - - - - - - - iSF_1195.SF2920,iUMNK88_1353.UMNK88_3626 FBPase_glpX k59_1117671_1 247634.GPB2148_2721 3.06e-75 244.0 COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,1RPCU@1236|Gammaproteobacteria,1J4ET@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S COG0488 ATPase components of ABC transporters with duplicated ATPase domains uup GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0008150,GO:0009314,GO:0009628,GO:0010528,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019219,GO:0019222,GO:0031323,GO:0044424,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051171,GO:0060255,GO:0065007,GO:0070894,GO:0071944,GO:0080090,GO:0097159,GO:1901363 - ko:K15738 - - - - ko00000,ko02000 3.A.1.120.6 - - ABC_tran,ABC_tran_CTD,ABC_tran_Xtn k59_1456515_1 1094508.Tsac_2416 7.94e-50 180.0 COG1345@1|root,COG5280@1|root,COG5412@1|root,COG1345@2|Bacteria,COG5280@2|Bacteria,COG5412@2|Bacteria,1TQ28@1239|Firmicutes,247QT@186801|Clostridia,42GRZ@68295|Thermoanaerobacterales 186801|Clostridia N tail tape measure protein TP901 core region - - - - - - - - - - - - PhageMin_Tail k59_388649_1 450851.PHZ_c1140 3.08e-22 97.1 COG0824@1|root,COG0824@2|Bacteria,1R6A6@1224|Proteobacteria,2TU6J@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Thioesterase - - - - - - - - - - - - - k59_777233_1 1304877.KI519399_gene5062 2.23e-11 63.9 COG0604@1|root,COG0604@2|Bacteria,1MW2V@1224|Proteobacteria,2U07M@28211|Alphaproteobacteria,3JQSM@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria C COG0604 NADPH quinone reductase and related Zn-dependent oxidoreductases - - - - - - - - - - - - ADH_N,ADH_zinc_N k59_777233_2 1121377.KB906398_gene2693 6.85e-17 80.9 COG1028@1|root,COG1028@2|Bacteria,1WM8P@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus IQ KR domain - - - - - - - - - - - - adh_short_C2 k59_165418_1 1122137.AQXF01000001_gene2763 4.1e-86 262.0 COG0596@1|root,COG0596@2|Bacteria,1QIT9@1224|Proteobacteria,2U8SV@28211|Alphaproteobacteria 28211|Alphaproteobacteria S hydrolases or acyltransferases (alpha beta hydrolase superfamily) - - - - - - - - - - - - Abhydrolase_1,Abhydrolase_6 k59_620697_1 566466.NOR53_3035 1.24e-83 266.0 COG0475@1|root,COG1226@1|root,COG0475@2|Bacteria,COG1226@2|Bacteria,1MV34@1224|Proteobacteria,1RNVR@1236|Gammaproteobacteria,1J52N@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family kefC - - ko:K03455,ko:K11745,ko:K11747 - - - - ko00000,ko02000 2.A.37,2.A.37.1.1,2.A.37.1.2 - - Na_H_Exchanger,TrkA_N k59_1747127_2 1459636.NTE_03340 5.42e-31 111.0 COG3432@1|root,arCOG01055@2157|Archaea 2157|Archaea K Transcriptional regulator - - - - - - - - - - - - HTH_45 k59_1293543_1 1385519.N801_18725 5.88e-36 124.0 COG0234@1|root,COG0234@2|Bacteria,2IKTH@201174|Actinobacteria,4FGWG@85021|Intrasporangiaceae 201174|Actinobacteria O Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter groS GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006355,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010033,GO:0010468,GO:0010556,GO:0016020,GO:0019219,GO:0019222,GO:0019899,GO:0030312,GO:0031323,GO:0031326,GO:0033554,GO:0034605,GO:0035375,GO:0035966,GO:0040007,GO:0042221,GO:0043167,GO:0043169,GO:0044424,GO:0044444,GO:0044464,GO:0046677,GO:0046872,GO:0050789,GO:0050794,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0051171,GO:0051252,GO:0051716,GO:0060255,GO:0061077,GO:0065007,GO:0071944,GO:0080090,GO:1903506,GO:2000112,GO:2001141 - ko:K04078 - - - - ko00000,ko03029,ko03110 - - - Cpn10 k59_903635_1 1458427.BAWN01000005_gene241 3.8e-43 152.0 COG0399@1|root,COG0399@2|Bacteria,1MUPN@1224|Proteobacteria,2VJDZ@28216|Betaproteobacteria,4AGKT@80864|Comamonadaceae 28216|Betaproteobacteria E Aminotransferase class-V - - 2.6.1.59 ko:K02805 - - - - ko00000,ko01000,ko01007 - - - DegT_DnrJ_EryC1 k59_1009870_1 1168065.DOK_09249 3.57e-53 177.0 COG4764@1|root,COG4764@2|Bacteria,1MVRK@1224|Proteobacteria,1RQ79@1236|Gammaproteobacteria,1J5V9@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S protein conserved in bacteria - - - - - - - - - - - - SLT k59_1349504_1 1123037.AUDE01000028_gene2974 3.14e-101 300.0 COG2360@1|root,COG2360@2|Bacteria,4NG3A@976|Bacteroidetes,1HY9J@117743|Flavobacteriia 976|Bacteroidetes O Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine aat - 2.3.2.6 ko:K00684 - - R03813,R11443,R11444 RC00055,RC00064 ko00000,ko01000 - - - Leu_Phe_trans k59_954510_1 768671.ThimaDRAFT_4344 7.75e-95 288.0 COG0714@1|root,COG0714@2|Bacteria,1MUFN@1224|Proteobacteria,1RN5G@1236|Gammaproteobacteria,1X2CM@135613|Chromatiales 135613|Chromatiales S associated with various cellular activities - - - ko:K03924 - - - - ko00000,ko01000 - - - AAA_3 k59_1293550_1 1459636.NTE_01565 5.78e-63 205.0 COG0475@1|root,arCOG01955@2157|Archaea,41SG1@651137|Thaumarchaeota 2157|Archaea P Sodium hydrogen exchanger - - - ko:K03455 - - - - ko00000 2.A.37 - - Na_H_Exchanger k59_1009878_1 744980.TRICHSKD4_6249 4.56e-70 224.0 COG0683@1|root,COG0683@2|Bacteria,1MWJ1@1224|Proteobacteria,2TT0T@28211|Alphaproteobacteria 28211|Alphaproteobacteria E ABC-type branched-chain amino acid transport systems, periplasmic component livJ - - ko:K01999 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - Peripla_BP_6 k59_1747147_1 349521.HCH_06350 6.13e-48 174.0 COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,1RNBG@1236|Gammaproteobacteria,1XI69@135619|Oceanospirillales 135619|Oceanospirillales L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity polA - 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1 k59_557341_1 1121918.ARWE01000001_gene1764 3.72e-65 222.0 COG0280@1|root,COG0281@1|root,COG0280@2|Bacteria,COG0281@2|Bacteria,1MU0A@1224|Proteobacteria,42MDI@68525|delta/epsilon subdivisions,2WIVY@28221|Deltaproteobacteria,43TZZ@69541|Desulfuromonadales 28221|Deltaproteobacteria C Malic enzyme, NAD binding domain maeB - 1.1.1.40 ko:K00029 ko00620,ko00710,ko01100,ko01120,ko01200,map00620,map00710,map01100,map01120,map01200 M00169,M00172 R00216 RC00105 ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_1637 Malic_M,PTA_PTB,malic k59_903654_1 1120956.JHZK01000021_gene1612 1.34e-25 110.0 COG0744@1|root,COG0744@2|Bacteria,1QTST@1224|Proteobacteria,2TQQ8@28211|Alphaproteobacteria,1JPZG@119043|Rhodobiaceae 28211|Alphaproteobacteria M Transglycosylase pbp - 2.4.1.129,3.4.16.4 ko:K05366 ko00550,ko01100,ko01501,map00550,map01100,map01501 - - - ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 - Transgly,Transpeptidase k59_1293588_1 927658.AJUM01000034_gene68 2.52e-22 102.0 COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,4NHS5@976|Bacteroidetes,2FN1K@200643|Bacteroidia,3XJPB@558415|Marinilabiliaceae 976|Bacteroidetes EU Prolyl oligopeptidase family - - - - - - - - - - - - PD40,Peptidase_S9 k59_446343_1 220664.PFL_3568 3e-51 175.0 COG0722@1|root,COG0722@2|Bacteria,1MU5Q@1224|Proteobacteria,1RMAA@1236|Gammaproteobacteria,1YNX4@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria E Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) aroF - 2.5.1.54 ko:K01626 ko00400,ko01100,ko01110,ko01130,ko01230,ko02024,map00400,map01100,map01110,map01130,map01230,map02024 M00022 R01826 RC00435 ko00000,ko00001,ko00002,ko01000 - - - DAHP_synth_1 k59_1747162_2 305700.B447_12519 7.01e-22 97.4 COG3026@1|root,COG3026@2|Bacteria,1MUQ8@1224|Proteobacteria,2VMZQ@28216|Betaproteobacteria,2KUKH@206389|Rhodocyclales 206389|Rhodocyclales T Sigma E regulatory protein, MucB RseB rseB - - ko:K03598 - - - - ko00000,ko03021 - - - MucB_RseB,MucB_RseB_C k59_843525_2 1278073.MYSTI_07016 3.55e-75 247.0 COG0642@1|root,COG2205@2|Bacteria,1RDRR@1224|Proteobacteria 1224|Proteobacteria T Histidine kinase phoR3 - - ko:K20971 ko02025,map02025 - - - ko00000,ko00001,ko01001,ko02022 - - - 7TMR-DISMED2,7TMR-DISM_7TM,HATPase_c,HisKA k59_843528_1 572477.Alvin_2856 8.17e-84 262.0 COG0154@1|root,COG0154@2|Bacteria,1MUVQ@1224|Proteobacteria,1RP7E@1236|Gammaproteobacteria,1WWC9@135613|Chromatiales 135613|Chromatiales J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) gatA - 6.3.5.6,6.3.5.7 ko:K02433 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - Amidase k59_903677_1 1122137.AQXF01000001_gene2694 1.06e-28 120.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,2TQR7@28211|Alphaproteobacteria 28211|Alphaproteobacteria T methyl-accepting chemotaxis protein - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - HAMP,MCPsignal,PilZ,dCache_1 k59_672543_1 1223410.KN050846_gene1816 1.47e-54 184.0 COG0438@1|root,COG0438@2|Bacteria,4NIP2@976|Bacteroidetes,1I2H3@117743|Flavobacteriia 976|Bacteroidetes M Glycosyl transferases group 1 - - - - - - - - - - - - Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1 k59_1747177_1 1168065.DOK_00425 8.45e-37 132.0 COG0280@1|root,COG0280@2|Bacteria,1QTS5@1224|Proteobacteria,1RMJS@1236|Gammaproteobacteria,1J5CB@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C belongs to the CobB CobQ family eutD GO:0003674,GO:0003824,GO:0006950,GO:0008150,GO:0008959,GO:0009266,GO:0009408,GO:0009628,GO:0016407,GO:0016740,GO:0016746,GO:0016747,GO:0050896 2.3.1.8 ko:K00625,ko:K04020,ko:K13788 ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200 M00357,M00579 R00230,R00921 RC00004,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000 - - iE2348C_1286.E2348C_2692 AAA_26,DRTGG,PTA_PTB k59_1747177_2 566466.NOR53_1433 8.68e-55 190.0 COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MUT8@1224|Proteobacteria,1RN6R@1236|Gammaproteobacteria,1J5MR@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Pyruvate phosphate dikinase ppdK - 2.7.3.9,2.7.9.1,2.7.9.2 ko:K01006,ko:K01007,ko:K08483 ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,ko02060,map00620,map00680,map00710,map00720,map01100,map01120,map01200,map02060 M00169,M00171,M00172,M00173,M00374 R00199,R00206 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000,ko02000 8.A.7 - - PEP-utilizers,PEP-utilizers_C,PPDK_N k59_395471_1 266779.Meso_3227 3.95e-42 152.0 COG1512@1|root,COG1512@2|Bacteria,1PB41@1224|Proteobacteria,2TUVD@28211|Alphaproteobacteria,43H59@69277|Phyllobacteriaceae 28211|Alphaproteobacteria S COG1512 Beta-propeller domains of methanol dehydrogenase type - - - ko:K06872 - - - - ko00000 - - - TPM_phosphatase k59_395480_1 1168065.DOK_02836 1.47e-73 236.0 COG0477@1|root,COG2814@2|Bacteria,1MU1I@1224|Proteobacteria,1RNTG@1236|Gammaproteobacteria,1J5ZS@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P the major facilitator superfamily emrB - - ko:K03446 - M00701 - - ko00000,ko00002,ko02000 2.A.1.3 - - MFS_1 k59_1412447_1 1088721.NSU_1812 2.17e-104 304.0 COG1403@1|root,COG1403@2|Bacteria,1MWEQ@1224|Proteobacteria,2TR3M@28211|Alphaproteobacteria,2K04Q@204457|Sphingomonadales 204457|Sphingomonadales L HNH endonuclease - - - - - - - - - - - - HNH_5 k59_501482_1 490103.B0FIG9_BPE32 2.21e-47 174.0 4QD9Y@10239|Viruses,4QUXQ@35237|dsDNA viruses no RNA stage,4QTPE@28883|Caudovirales,4QNY4@10744|Podoviridae 10744|Podoviridae S Terminase-like family - - - - - - - - - - - - - k59_1412461_1 313612.L8106_10612 9.24e-28 116.0 COG0652@1|root,COG2133@1|root,COG2885@1|root,COG2931@1|root,COG3291@1|root,COG0652@2|Bacteria,COG2133@2|Bacteria,COG2885@2|Bacteria,COG2931@2|Bacteria,COG3291@2|Bacteria,1G0DX@1117|Cyanobacteria,1H8AY@1150|Oscillatoriales 1117|Cyanobacteria Q COG2931 RTX toxins and related Ca2 -binding - - - - - - - - - - - - Cadherin_3,DUF11,DUF4347,HemolysinCabind,Laminin_G_3,VCBS k59_733682_1 452637.Oter_4228 1.87e-41 151.0 COG0559@1|root,COG0559@2|Bacteria,46U7D@74201|Verrucomicrobia,3K73C@414999|Opitutae 414999|Opitutae P Urea ABC transporter permease - - - ko:K11960 ko02010,map02010 M00323 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4.4,3.A.1.4.5 - - BPD_transp_2 k59_733682_2 452637.Oter_4227 1.56e-31 121.0 COG4177@1|root,COG4177@2|Bacteria,46S8E@74201|Verrucomicrobia,3K7EY@414999|Opitutae 414999|Opitutae P Urea ABC transporter permease - - - ko:K11961 ko02010,map02010 M00323 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4.4,3.A.1.4.5 - - BPD_transp_2 k59_222687_1 237368.SCABRO_03837 1.82e-16 86.3 29MQ2@1|root,308MT@2|Bacteria,2J179@203682|Planctomycetes 203682|Planctomycetes - - - - - - - - - - - - - - - k59_1412462_2 1229909.NSED_09275 2.11e-31 110.0 arCOG11612@1|root,arCOG11612@2157|Archaea,41T8D@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1634979_2 452637.Oter_3243 1.46e-08 63.5 COG0489@1|root,COG3206@1|root,COG0489@2|Bacteria,COG3206@2|Bacteria,46ZJI@74201|Verrucomicrobia,3K7RY@414999|Opitutae 414999|Opitutae D AAA domain - - - - - - - - - - - - CbiA k59_1634979_3 639030.JHVA01000001_gene3247 6.5e-18 85.9 COG3267@1|root,COG3267@2|Bacteria,3Y6P4@57723|Acidobacteria,2JKNX@204432|Acidobacteriia 204432|Acidobacteriia U AAA domain - - - - - - - - - - - - AAA_22 k59_280777_1 397945.Aave_1482 2.73e-112 350.0 COG0542@1|root,COG0542@2|Bacteria,1MVBH@1224|Proteobacteria,2VHSN@28216|Betaproteobacteria,4AAVS@80864|Comamonadaceae 28216|Betaproteobacteria O TIGRFAM type VI secretion ATPase, ClpV1 family clpV - - ko:K11907 ko02025,ko03070,map02025,map03070 M00334 - - ko00000,ko00001,ko00002,ko02044 3.A.23.1 - - AAA,AAA_2,ClpB_D2-small,Clp_N k59_557420_1 1219035.NT2_06_02940 2.23e-74 224.0 COG0698@1|root,COG0698@2|Bacteria,1RHBF@1224|Proteobacteria,2U94R@28211|Alphaproteobacteria,2K4KN@204457|Sphingomonadales 204457|Sphingomonadales G Ribose 5-phosphate isomerase rpiB - 5.3.1.6 ko:K01808 ko00030,ko00051,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00051,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01056,R09030 RC00376,RC00434 ko00000,ko00001,ko00002,ko01000 - - - LacAB_rpiB k59_557420_2 158500.BV97_00684 1.54e-23 98.2 COG0112@1|root,COG0112@2|Bacteria,1MUIS@1224|Proteobacteria,2TQKT@28211|Alphaproteobacteria,2K0BB@204457|Sphingomonadales 204457|Sphingomonadales E Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism glyA - 2.1.2.1 ko:K00600 ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523 M00140,M00141,M00346,M00532 R00945,R09099 RC00022,RC00112,RC01583,RC02958 ko00000,ko00001,ko00002,ko01000 - - - SHMT k59_1463419_1 436308.Nmar_1306 7.54e-41 137.0 COG0640@1|root,arCOG03067@2157|Archaea,41TA3@651137|Thaumarchaeota 651137|Thaumarchaeota K transcriptional regulators - - - - - - - - - - - - - k59_1463421_1 296591.Bpro_2004 7.89e-90 272.0 COG2358@1|root,COG2358@2|Bacteria,1MXW1@1224|Proteobacteria,2VH6G@28216|Betaproteobacteria,4ABRZ@80864|Comamonadaceae 28216|Betaproteobacteria S NMT1-like family - - - ko:K07080 - - - - ko00000 - - - NMT1_3 k59_954593_1 1229909.NSED_05840 5.11e-93 293.0 COG0145@1|root,arCOG01511@2157|Archaea,41SZ7@651137|Thaumarchaeota 651137|Thaumarchaeota E N-methylhydantoinase A acetone carboxylase, beta subunit - - - - - - - - - - - - Hydant_A_N,Hydantoinase_A k59_954593_2 1229909.NSED_05845 2.84e-18 84.0 COG0672@1|root,arCOG04330@2157|Archaea,41T07@651137|Thaumarchaeota 651137|Thaumarchaeota P High-affinity Fe2 Pb2 permease - - - ko:K07243 - - - - ko00000,ko02000 2.A.108.1,2.A.108.2 - - FTR1 k59_1690321_1 296591.Bpro_3743 8.87e-15 74.7 COG5003@1|root,COG5003@2|Bacteria,1PZWK@1224|Proteobacteria,2W4G4@28216|Betaproteobacteria 28216|Betaproteobacteria S Domain of unknown function (DUF1834) - - - - - - - - - - - - DUF1834 k59_1690321_2 1187848.AJYQ01000156_gene3816 2.05e-06 47.8 2EICU@1|root,33C46@2|Bacteria,1NGMA@1224|Proteobacteria,1SGJZ@1236|Gammaproteobacteria,1XZI9@135623|Vibrionales 135623|Vibrionales S Protein of unknown function (DUF2635) - - - - - - - - - - - - DUF2635 k59_1690321_3 1187848.AJYQ01000156_gene3815 1.6e-06 49.7 COG4386@1|root,COG4386@2|Bacteria,1MXZD@1224|Proteobacteria,1RN4Q@1236|Gammaproteobacteria,1XWPC@135623|Vibrionales 135623|Vibrionales S Phage tail sheath C-terminal domain - - - - - - - - - - - - Phage_sheath_1,Phage_sheath_1C k59_222706_1 1229780.BN381_80371 7.57e-05 45.4 COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,2GKXV@201174|Actinobacteria 201174|Actinobacteria C Ferredoxin oxidoreductase porA - 1.2.7.11,1.2.7.3 ko:K00174 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - PFOR_II,POR,POR_N k59_222706_2 446468.Ndas_5088 4.97e-77 239.0 COG1013@1|root,COG1013@2|Bacteria,2GMI5@201174|Actinobacteria,4EH97@85012|Streptosporangiales 201174|Actinobacteria C Thiamine pyrophosphate enzyme, C-terminal TPP binding domain korB - 1.2.7.11,1.2.7.3 ko:K00175 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C k59_222714_1 123899.JPQP01000020_gene1902 3.66e-60 204.0 COG1502@1|root,COG1502@2|Bacteria,1MUDJ@1224|Proteobacteria,2VHSI@28216|Betaproteobacteria,3T1RJ@506|Alcaligenaceae 28216|Betaproteobacteria I COG1502 Phosphatidylserine phosphatidylglycerophosphate cardiolipi n synthases and related enzymes - - - ko:K06132 ko00564,ko01100,map00564,map01100 - R11062 RC00017 ko00000,ko00001,ko01000 - - - PLDc_2 k59_1183117_1 1212548.B381_03497 2.99e-107 332.0 COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,1RQ2G@1236|Gammaproteobacteria,1Z2AH@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins ftsH_1 - - ko:K03798 - M00742 - - ko00000,ko00002,ko01000,ko01002,ko03110 - - - AAA,FtsH_ext,Peptidase_M41 k59_1799643_1 518766.Rmar_2521 3.75e-194 560.0 COG2234@1|root,COG2234@2|Bacteria,4NFDJ@976|Bacteroidetes,1FKC5@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes S Peptidase family M28 - - - - - - - - - - - - PA,Peptidase_M28 k59_903782_1 247634.GPB2148_474 5.26e-16 82.4 COG3213@1|root,COG3213@2|Bacteria,1MUJK@1224|Proteobacteria,1RMCR@1236|Gammaproteobacteria,1J6E8@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P involved in response to NO nnrS - - ko:K07234 - - - - ko00000 - - - NnrS k59_557462_1 585503.HMPREF7545_0781 9.96e-52 181.0 COG0326@1|root,COG0326@2|Bacteria,1TQEU@1239|Firmicutes,4H2HJ@909932|Negativicutes 909932|Negativicutes O Molecular chaperone. Has ATPase activity htpG - - ko:K04079 ko04141,ko04151,ko04217,ko04612,ko04621,ko04626,ko04657,ko04659,ko04914,ko04915,ko05200,ko05215,ko05418,map04141,map04151,map04217,map04612,map04621,map04626,map04657,map04659,map04914,map04915,map05200,map05215,map05418 - - - ko00000,ko00001,ko01009,ko03029,ko03051,ko03110,ko04131,ko04147 - - - HATPase_c,HATPase_c_3,HSP90 k59_1524779_1 1144305.PMI02_00878 6.89e-133 389.0 COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2TQR1@28211|Alphaproteobacteria,2JZVD@204457|Sphingomonadales 204457|Sphingomonadales C belongs to the aldehyde dehydrogenase family - - 1.2.1.39 ko:K00146 ko00360,ko00643,ko01100,ko01120,map00360,map00643,map01100,map01120 - R02536 RC00080 ko00000,ko00001,ko01000 - - - Aldedh k59_280816_1 1122137.AQXF01000002_gene384 3.48e-88 268.0 COG0834@1|root,COG0834@2|Bacteria,1MY7Y@1224|Proteobacteria,2UHUS@28211|Alphaproteobacteria 28211|Alphaproteobacteria ET Bacterial extracellular solute-binding proteins, family 3 - - - ko:K02030 - M00236 - - ko00000,ko00002,ko02000 3.A.1.3 - - SBP_bac_3 k59_1690346_2 740709.A10D4_01215 5.69e-77 246.0 COG0577@1|root,COG0577@2|Bacteria,1MXFC@1224|Proteobacteria,1RQX0@1236|Gammaproteobacteria,2QGAM@267893|Idiomarinaceae 1236|Gammaproteobacteria V MacB-like periplasmic core domain - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_111233_1 1121897.AUGO01000008_gene2607 2.13e-109 321.0 COG3064@1|root,COG3064@2|Bacteria,4NEVD@976|Bacteroidetes,1HXMP@117743|Flavobacteriia,2NZXK@237|Flavobacterium 976|Bacteroidetes M membrane - - - - - - - - - - - - PorP_SprF k59_785510_1 33898.JRHJ01000076_gene195 2.02e-05 53.1 COG1680@1|root,COG1680@2|Bacteria,2GIX5@201174|Actinobacteria 201174|Actinobacteria V Beta-lactamase - - 3.4.16.4 ko:K01286 - - - - ko00000,ko01000 - - - Beta-lactamase k59_112775_1 580340.Tlie_1476 8.42e-66 213.0 COG0436@1|root,COG0436@2|Bacteria,3TC22@508458|Synergistetes 508458|Synergistetes E DegT/DnrJ/EryC1/StrS aminotransferase family - - - - - - - - - - - - Aminotran_1_2 k59_112777_1 1209072.ALBT01000023_gene3944 4.63e-52 172.0 COG3665@1|root,COG3665@2|Bacteria,1N2KR@1224|Proteobacteria,1RN5H@1236|Gammaproteobacteria,1FGKU@10|Cellvibrio 1236|Gammaproteobacteria S Domain of unknown function (DUF1989) IV02_09290 - - ko:K09967 - - - - ko00000 - - - DUF1989 k59_112777_2 382464.ABSI01000002_gene4382 1.52e-21 89.7 COG3665@1|root,COG3665@2|Bacteria,46UWG@74201|Verrucomicrobia,2IU25@203494|Verrucomicrobiae 203494|Verrucomicrobiae S Domain of unknown function (DUF1989) - - - - - - - - - - - - DUF1989 k59_503022_1 234267.Acid_5256 5.98e-11 61.2 COG2318@1|root,COG2318@2|Bacteria,3Y4TA@57723|Acidobacteria 57723|Acidobacteria S Mycothiol maleylpyruvate isomerase N-terminal domain - - - - - - - - - - - - DinB_2 k59_845263_1 1207063.P24_11145 2.79e-27 112.0 COG0845@1|root,COG0845@2|Bacteria,1MVFN@1224|Proteobacteria,2TRSC@28211|Alphaproteobacteria,2JRQT@204441|Rhodospirillales 204441|Rhodospirillales M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - ko:K18990 - M00720 - - ko00000,ko00002,ko02000 2.A.6.2.30,8.A.1 - - HlyD_D23 k59_1476578_1 717605.Theco_1838 1.6e-25 108.0 COG0287@1|root,COG0287@2|Bacteria,1TPXG@1239|Firmicutes,4HBI4@91061|Bacilli,26SZR@186822|Paenibacillaceae 91061|Bacilli E prephenate dehydrogenase tyrA GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006520,GO:0006570,GO:0006571,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008977,GO:0009058,GO:0009072,GO:0009073,GO:0009095,GO:0009987,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0019438,GO:0019752,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0070403,GO:0071704,GO:0097159,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.3.1.12 ko:K04517 ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230 M00025 R01728 RC00125 ko00000,ko00001,ko00002,ko01000 - - iYO844.BSU22610 ACT,PDH k59_1307036_1 63737.Npun_R3025 1.33e-59 207.0 COG1020@1|root,COG1020@2|Bacteria,1G0XE@1117|Cyanobacteria,1HKNU@1161|Nostocales 1117|Cyanobacteria Q TIGRFAM amino acid adenylation domain - - - - - - - - - - - - AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase k59_233127_1 428126.CLOSPI_02182 2.49e-17 84.3 COG0601@1|root,COG0601@2|Bacteria,1TP1S@1239|Firmicutes,3VNY0@526524|Erysipelotrichia 526524|Erysipelotrichia P Psort location CytoplasmicMembrane, score 10.00 - - - ko:K02033 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1 k59_967560_1 298654.FraEuI1c_3036 3.16e-58 193.0 COG0438@1|root,COG0438@2|Bacteria,2IABI@201174|Actinobacteria,4ETU6@85013|Frankiales 201174|Actinobacteria M Sulfotransferase domain - - - - - - - - - - - - Sulfotransfer_3 k59_911446_1 203122.Sde_0814 1.7e-44 162.0 COG4232@1|root,COG4232@2|Bacteria,1MU8W@1224|Proteobacteria,1RPF7@1236|Gammaproteobacteria,46550@72275|Alteromonadaceae 1236|Gammaproteobacteria CO Thiol disulfide interchange protein dsbD - 1.8.1.8 ko:K04084 - - - - ko00000,ko01000,ko03110 5.A.1.1 - - DsbC,DsbD,Thioredoxin_7 k59_515357_1 1089545.KB913037_gene8116 1.75e-45 166.0 COG4805@1|root,COG4805@2|Bacteria,2GMUR@201174|Actinobacteria,4DZQU@85010|Pseudonocardiales 201174|Actinobacteria S Bacterial protein of unknown function (DUF885) - - - - - - - - - - - - DUF885 k59_856227_1 1128421.JAGA01000003_gene3683 9.63e-50 180.0 COG5297@1|root,COG5297@2|Bacteria,2NQDB@2323|unclassified Bacteria 2|Bacteria G CBD_II - - 3.2.1.91 ko:K19668 ko00500,ko01100,ko02020,map00500,map01100,map02020 - R02886,R11308 RC00799 ko00000,ko00001,ko01000 - GH6 - CBM_10,CBM_2,Glyco_hydro_6,PKD k59_65490_2 1417296.U879_03770 1.36e-07 53.1 COG2721@1|root,COG2721@2|Bacteria,1MU9V@1224|Proteobacteria,2TTDT@28211|Alphaproteobacteria 28211|Alphaproteobacteria G D-galactarate dehydratase Altronate hydrolase garD GO:0003674,GO:0003824,GO:0005975,GO:0006082,GO:0008150,GO:0008152,GO:0008867,GO:0009056,GO:0009987,GO:0016052,GO:0016054,GO:0016829,GO:0016835,GO:0016836,GO:0019577,GO:0019579,GO:0019580,GO:0019752,GO:0043436,GO:0043648,GO:0043649,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0046392,GO:0046395,GO:0071704,GO:1901575 4.2.1.7 ko:K01685 ko00040,ko01100,map00040,map01100 M00631 R01540 RC00543 ko00000,ko00001,ko00002,ko01000 - - - GD_AH_C,SAF k59_1589856_1 1348583.ATLH01000016_gene3464 7.29e-10 59.7 COG4902@1|root,COG4902@2|Bacteria,4NNNJ@976|Bacteroidetes,1I2NY@117743|Flavobacteriia 976|Bacteroidetes S Uncharacterized protein domain (DUF2202) - - - - - - - - - - - - DUF2202 k59_1420382_1 297246.lpp3054 6.99e-16 77.8 COG0224@1|root,COG0224@2|Bacteria,1MU28@1224|Proteobacteria,1RNWJ@1236|Gammaproteobacteria,1JCPD@118969|Legionellales 118969|Legionellales C Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex atpG - - ko:K02115 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt k59_1420382_2 632245.CLP_3722 1.96e-46 166.0 COG0056@1|root,COG0056@2|Bacteria,1TNZ8@1239|Firmicutes,248IY@186801|Clostridia,36ENE@31979|Clostridiaceae 186801|Clostridia C Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit atpA GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 3.6.3.14 ko:K02111 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - - ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N k59_291429_1 1134474.O59_001439 1.49e-101 314.0 COG0556@1|root,COG0556@2|Bacteria,1MUFK@1224|Proteobacteria,1RN6Z@1236|Gammaproteobacteria,1FH04@10|Cellvibrio 1236|Gammaproteobacteria L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage uvrB GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009314,GO:0009380,GO:0009628,GO:0032991,GO:0042802,GO:0044424,GO:0044464,GO:0050896,GO:1902494,GO:1905347,GO:1905348,GO:1990391 - ko:K03702 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - Helicase_C,ResIII,UVR,UvrB k59_1138095_1 1443665.JACA01000042_gene1723 5.4e-07 50.4 COG5263@1|root,COG5263@2|Bacteria,4NJ6B@976|Bacteroidetes,1HX7Q@117743|Flavobacteriia,2YKC2@290174|Aquimarina 976|Bacteroidetes S WG containing repeat - - - - - - - - - - - - WG_beta_rep k59_1138095_2 216432.CA2559_03910 1.86e-133 383.0 COG1028@1|root,COG1028@2|Bacteria,4NFTU@976|Bacteroidetes,1HX2B@117743|Flavobacteriia 976|Bacteroidetes IQ reductase fabG3 - 1.1.1.100,1.1.1.36 ko:K00023,ko:K00059 ko00061,ko00333,ko00630,ko00650,ko00780,ko01040,ko01100,ko01120,ko01130,ko01200,ko01212,map00061,map00333,map00630,map00650,map00780,map01040,map01100,map01120,map01130,map01200,map01212 M00083,M00373,M00572 R01779,R01977,R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00103,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 k59_1138095_3 1268240.ATFI01000004_gene4147 1.98e-10 60.5 COG0304@1|root,COG0304@2|Bacteria,4NFBN@976|Bacteroidetes,2FNHE@200643|Bacteroidia,4AM5N@815|Bacteroidaceae 976|Bacteroidetes IQ Belongs to the beta-ketoacyl-ACP synthases family fabB - 2.3.1.41 ko:K00647 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119 RC00039,RC02728,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Ketoacyl-synt_C,ketoacyl-synt k59_799930_1 903818.KI912268_gene1090 5.32e-44 159.0 COG1639@1|root,COG2204@1|root,COG1639@2|Bacteria,COG2204@2|Bacteria 2|Bacteria T phosphorelay signal transduction system phcR - - ko:K19622 ko02020,map02020 - - - ko00000,ko00001,ko02022 - - - HATPase_c,HDOD,Response_reg k59_460257_1 953739.SVEN_1077 1.35e-54 186.0 COG0452@1|root,COG0452@2|Bacteria,2GJGJ@201174|Actinobacteria 201174|Actinobacteria H Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine coaBC GO:0003674,GO:0003824,GO:0004633,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016020,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044464,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.1.36,6.3.2.5 ko:K13038 ko00770,ko01100,map00770,map01100 M00120 R03269,R04231 RC00064,RC00090,RC00822 ko00000,ko00001,ko00002,ko01000 - - - DFP,Flavoprotein k59_799932_1 199310.c1027 1.27e-120 377.0 COG1178@1|root,COG1674@1|root,COG1178@2|Bacteria,COG1674@2|Bacteria,1MVPI@1224|Proteobacteria,1RM9A@1236|Gammaproteobacteria,3XN27@561|Escherichia 1236|Gammaproteobacteria D Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region. Translocation stops specifically at Xer-dif sites, where FtsK interacts with the Xer recombinase, allowing activation of chromosome unlinking by recombination. FtsK orienting polar sequences (KOPS) guide the direction of DNA translocation. FtsK can remove proteins from DNA as it translocates, but translocation stops specifically at XerCD-dif site, thereby preventing removal of XerC and XerD from dif ftsK GO:0000920,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006355,GO:0006950,GO:0006970,GO:0007059,GO:0008094,GO:0008150,GO:0009628,GO:0009651,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0015616,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019219,GO:0019222,GO:0031224,GO:0031226,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0033676,GO:0042221,GO:0042623,GO:0042802,GO:0043085,GO:0043565,GO:0044093,GO:0044425,GO:0044459,GO:0044464,GO:0045893,GO:0045935,GO:0046677,GO:0048518,GO:0048522,GO:0050789,GO:0050790,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051301,GO:0051716,GO:0060255,GO:0065007,GO:0065009,GO:0070887,GO:0071236,GO:0071944,GO:0080090,GO:0097159,GO:0140097,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141 - ko:K03466 - - - - ko00000,ko03036 3.A.12 - - FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma k59_177745_1 69395.JQLZ01000002_gene1001 1.34e-69 228.0 COG0642@1|root,COG2205@2|Bacteria,1MUAK@1224|Proteobacteria,2TSUC@28211|Alphaproteobacteria,2KEYY@204458|Caulobacterales 204458|Caulobacterales T histidine kinase HAMP region domain protein - - - - - - - - - - - - HAMP,HATPase_c k59_1251356_1 983920.Y88_0023 2.92e-74 234.0 COG0399@1|root,COG0399@2|Bacteria,1MUPN@1224|Proteobacteria,2TRIQ@28211|Alphaproteobacteria,2KD20@204457|Sphingomonadales 204457|Sphingomonadales E Belongs to the DegT DnrJ EryC1 family - - - - - - - - - - - - DegT_DnrJ_EryC1 k59_8801_1 269800.Tfu_2021 4e-60 205.0 COG0322@1|root,COG0322@2|Bacteria,2GIS4@201174|Actinobacteria,4EHD5@85012|Streptosporangiales 201174|Actinobacteria L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision uvrC GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0006950,GO:0006974,GO:0008150,GO:0009380,GO:0009987,GO:0016020,GO:0030312,GO:0032991,GO:0033554,GO:0040007,GO:0044424,GO:0044464,GO:0050896,GO:0051716,GO:0071944,GO:1902494,GO:1905347,GO:1905348,GO:1990391 - ko:K03703 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - GIY-YIG,HHH_2,HHH_5,UVR,UvrC_HhH_N k59_177748_1 1123487.KB892865_gene1380 1.05e-166 490.0 COG3170@1|root,COG3170@2|Bacteria,1PMRK@1224|Proteobacteria,2W7ZG@28216|Betaproteobacteria,2KZB6@206389|Rhodocyclales 206389|Rhodocyclales NU Tfp pilus assembly protein FimV - - - - - - - - - - - - - k59_291450_1 745014.OMB55_00010160 4.5e-105 314.0 COG1960@1|root,COG1960@2|Bacteria,1MU2V@1224|Proteobacteria,1RNJH@1236|Gammaproteobacteria,1J4QM@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C COG1960 Acyl-CoA dehydrogenases - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_856258_1 215803.DB30_4733 2e-07 55.5 COG3064@1|root,COG3064@2|Bacteria,1QX7A@1224|Proteobacteria,43C08@68525|delta/epsilon subdivisions,2X7AZ@28221|Deltaproteobacteria,2YYPY@29|Myxococcales 28221|Deltaproteobacteria M YXWGXW repeat (2 copies) - - - - - - - - - - - - YXWGXW k59_516436_1 1187851.A33M_4387 1.08e-83 266.0 COG0069@1|root,COG2218@1|root,COG0069@2|Bacteria,COG2218@2|Bacteria,1MU7B@1224|Proteobacteria,2TREH@28211|Alphaproteobacteria,3FD8Z@34008|Rhodovulum 28211|Alphaproteobacteria E Conserved region in glutamate synthase - - - - - - - - - - - - Glu_synthase,zf-CDGSH k59_629718_1 717605.Theco_2126 1.37e-49 167.0 COG0336@1|root,COG0336@2|Bacteria,1TPBV@1239|Firmicutes,4HBFV@91061|Bacilli,26RCU@186822|Paenibacillaceae 91061|Bacilli J Belongs to the RNA methyltransferase TrmD family trmD GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009019,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0016772,GO:0016779,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050518,GO:0070567,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.1.1.228 ko:K00554 - - R00597 RC00003,RC00334 ko00000,ko01000,ko03016 - - - tRNA_m1G_MT k59_8812_1 247634.GPB2148_3313 5.52e-65 201.0 COG1545@1|root,COG1545@2|Bacteria,1N9MM@1224|Proteobacteria,1SQKT@1236|Gammaproteobacteria,1JAQN@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S DUF35 OB-fold domain, acyl-CoA-associated - - - - - - - - - - - - OB_aCoA_assoc k59_1364569_1 232721.Ajs_3343 7.28e-11 64.3 COG2847@1|root,COG2847@2|Bacteria,1MZ3M@1224|Proteobacteria,2VTY7@28216|Betaproteobacteria,4AEN7@80864|Comamonadaceae 28216|Betaproteobacteria S Copper chaperone PCu(A)C - - - ko:K09796 - - - - ko00000,ko03110 - - - PCuAC k59_1364569_2 626887.J057_05456 1.75e-29 111.0 COG0071@1|root,COG0071@2|Bacteria,1N7C7@1224|Proteobacteria,1S607@1236|Gammaproteobacteria,468FQ@72275|Alteromonadaceae 1236|Gammaproteobacteria O Belongs to the small heat shock protein (HSP20) family - - - ko:K13993 ko04141,map04141 - - - ko00000,ko00001,ko03110 - - - HSP20 k59_516444_1 1229909.NSED_08020 1.06e-101 307.0 COG0015@1|root,arCOG01747@2157|Archaea,41SD1@651137|Thaumarchaeota 651137|Thaumarchaeota F adenylosuccinate lyase - - 4.3.2.2 ko:K01756 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048,M00049 R01083,R04559 RC00379,RC00444,RC00445 ko00000,ko00001,ko00002,ko01000 - - - ADSL_C,Lyase_1 k59_912456_1 589865.DaAHT2_2197 3.86e-41 152.0 COG5616@1|root,COG5616@2|Bacteria,1RBBE@1224|Proteobacteria,42QR8@68525|delta/epsilon subdivisions,2WN1X@28221|Deltaproteobacteria,2MHSI@213118|Desulfobacterales 28221|Deltaproteobacteria S PFAM Curli production assembly transport component CsgG - - - - - - - - - - - - CsgG,VCBS k59_912460_1 240302.BN982_00238 7.23e-25 107.0 COG0457@1|root,COG0705@1|root,COG0457@2|Bacteria,COG0705@2|Bacteria,1TQXT@1239|Firmicutes,4HCDF@91061|Bacilli,3NE1J@45667|Halobacillus 91061|Bacilli S Rhomboid family gluP - 3.4.21.105 ko:K19225 - - - - ko00000,ko01000,ko01002 - - - Rhomboid,TPR_2,TPR_8 k59_686130_1 1333998.M2A_2283 6.66e-28 115.0 COG1520@1|root,COG1520@2|Bacteria,1MXIJ@1224|Proteobacteria,2TUAD@28211|Alphaproteobacteria,4BQ2V@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria S PQQ-like domain bamB - - ko:K17713 - - - - ko00000,ko02000 1.B.33.1 - - PQQ_2,PQQ_3 k59_686130_2 1122137.AQXF01000002_gene292 1.49e-35 130.0 COG4649@1|root,COG4649@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - TPR_21 k59_177766_1 1229909.NSED_08320 2.15e-14 69.3 COG1325@1|root,arCOG01042@2157|Archaea,41SWK@651137|Thaumarchaeota 651137|Thaumarchaeota J RNA binding - - - ko:K07581 - - - - ko00000 - - - RNA_binding k59_177766_2 436308.Nmar_1512 2.91e-129 369.0 COG1890@1|root,arCOG04186@2157|Archaea,41SM9@651137|Thaumarchaeota 651137|Thaumarchaeota J Belongs to the eukaryotic ribosomal protein eS1 family rps3ae - - ko:K02984 ko03010,map03010 M00177,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S3Ae k59_1420427_1 1123400.KB904761_gene2504 2.33e-165 483.0 COG0480@1|root,COG0480@2|Bacteria,1MUCV@1224|Proteobacteria,1RNNJ@1236|Gammaproteobacteria,4607G@72273|Thiotrichales 72273|Thiotrichales J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome - - - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2 k59_799969_1 314285.KT71_04010 8.34e-102 303.0 COG3496@1|root,COG3496@2|Bacteria,1RC56@1224|Proteobacteria,1RRT8@1236|Gammaproteobacteria,1J601@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Protein of unknown function (DUF1365) - - - ko:K09701 - - - - ko00000 - - - DUF1365 k59_799969_2 565045.NOR51B_475 3.66e-39 142.0 COG2907@1|root,COG2907@2|Bacteria,1MV4Z@1224|Proteobacteria,1RP4P@1236|Gammaproteobacteria,1J551@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Amine oxidase flavin-containing - - - ko:K06954 - - - - ko00000 - - - Amino_oxidase,NAD_binding_8 k59_516497_1 1147153.K7PLU3_9CAUD 3e-31 123.0 4QBU2@10239|Viruses,4QV13@35237|dsDNA viruses no RNA stage,4QPH3@28883|Caudovirales,4QM65@10699|Siphoviridae 10699|Siphoviridae S IstB-like ATP binding protein - - - - - - - - - - - - - k59_516497_2 1117958.PE143B_0130405 1.3e-42 152.0 28N2X@1|root,2ZB8P@2|Bacteria,1R4KJ@1224|Proteobacteria,1T3E3@1236|Gammaproteobacteria 1236|Gammaproteobacteria S sty2063 SWALL Q8Z5Z8 (EMBL AL627272) (262 aa) fasta scores E() 1.5e-07, 24.43 id in 266 aa, and to Escherichia coli O157 H7 - - - - - - - - - - - - - k59_968573_2 522373.Smlt4595 1.62e-06 48.9 COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,1RNJI@1236|Gammaproteobacteria,1X3W3@135614|Xanthomonadales 135614|Xanthomonadales L Unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present uvrD - 3.6.4.12 ko:K03657 ko03420,ko03430,map03420,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - UvrD-helicase,UvrD_C k59_799982_1 1046627.BZARG_1277 1.12e-112 344.0 COG2183@1|root,COG2183@2|Bacteria,4NETD@976|Bacteroidetes,1HXWN@117743|Flavobacteriia 976|Bacteroidetes K RNA binding protein with S1 RNA-binding domain yhgF - - ko:K06959 - - - - ko00000 - - - HHH_3,S1,Tex_N,Tex_YqgF k59_121831_1 395494.Galf_1624 1.54e-36 125.0 COG0776@1|root,COG0776@2|Bacteria,1MZ5B@1224|Proteobacteria,2VU4V@28216|Betaproteobacteria,44W21@713636|Nitrosomonadales 28216|Betaproteobacteria L bacterial (prokaryotic) histone like domain hupB - - ko:K03530 - - - - ko00000,ko03032,ko03036,ko03400 - - - Bac_DNA_binding k59_291476_1 1415778.JQMM01000001_gene2100 2.91e-166 477.0 COG0577@1|root,COG0577@2|Bacteria,1PBKH@1224|Proteobacteria,1T1FT@1236|Gammaproteobacteria,1J5IY@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria V COG0577 ABC-type antimicrobial peptide transport system, permease component VP1997 - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_291476_2 1415778.JQMM01000001_gene2101 6.46e-147 427.0 COG0577@1|root,COG0577@2|Bacteria,1PBKH@1224|Proteobacteria,1T1FT@1236|Gammaproteobacteria,1J5FS@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria V MacB-like periplasmic core domain VP1997 - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_516514_2 1229909.NSED_07515 1.97e-71 219.0 COG2890@1|root,arCOG00109@2157|Archaea,41SSD@651137|Thaumarchaeota 651137|Thaumarchaeota Q Methyltransferase small domain - - 2.1.1.297 ko:K02493 - - R10806 RC00003,RC03279 ko00000,ko01000,ko03012 - - - MTS k59_1647112_2 765910.MARPU_05055 7.45e-60 190.0 COG1267@1|root,COG1267@2|Bacteria,1MZJA@1224|Proteobacteria,1S68A@1236|Gammaproteobacteria,1WY89@135613|Chromatiales 135613|Chromatiales I Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG) - - 3.1.3.27 ko:K01095 ko00564,ko01100,map00564,map01100 - R02029 RC00017 ko00000,ko00001,ko01000 - - - PgpA k59_65598_1 631362.Thi970DRAFT_03536 1.89e-92 300.0 COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,1MV6G@1224|Proteobacteria,1RMYD@1236|Gammaproteobacteria,1WW84@135613|Chromatiales 135613|Chromatiales E Vitamin B12 dependent methionine synthase activation metH - 2.1.1.13 ko:K00548 ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230 M00017 R00946,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 - - - B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans k59_516515_1 551789.ATVJ01000001_gene1173 5.52e-22 99.0 COG0642@1|root,COG0784@1|root,COG0784@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,2V7E0@28211|Alphaproteobacteria,43WW8@69657|Hyphomonadaceae 28211|Alphaproteobacteria T sensor histidine kinase response regulator - - - - - - - - - - - - HATPase_c,HisKA,PAS,Response_reg k59_8863_1 194867.ALBQ01000059_gene3383 4.03e-98 306.0 COG4987@1|root,COG4987@2|Bacteria,1QU1P@1224|Proteobacteria,2TV54@28211|Alphaproteobacteria,2JZZJ@204457|Sphingomonadales 204457|Sphingomonadales CO COG4987 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components cydC - - ko:K16012 ko02010,map02010 - - - ko00000,ko00001,ko02000 3.A.1.129 - - ABC_membrane,ABC_tran k59_1138158_1 1454004.AW11_02145 7.21e-71 225.0 COG1215@1|root,COG1215@2|Bacteria,1QTWU@1224|Proteobacteria,2WGWG@28216|Betaproteobacteria 28216|Betaproteobacteria M Glycosyl transferase family 2 - - - ko:K20534 - - - - ko00000,ko01000,ko01005,ko02000 4.D.2.1.9 GT2 - Glycos_transf_2 k59_8872_1 1219045.BV98_002756 1.14e-92 301.0 COG1629@1|root,COG4771@2|Bacteria,1R4SS@1224|Proteobacteria 1224|Proteobacteria P TonB dependent receptor - - - - - - - - - - - - Plug,TonB_dep_Rec k59_234216_1 1049564.TevJSym_aj00080 4.47e-10 60.8 COG3637@1|root,COG3637@2|Bacteria,1RDPZ@1224|Proteobacteria,1S4GQ@1236|Gammaproteobacteria,1JADW@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety - - - - - - - - - - - - OMP_b-brl k59_234216_2 203122.Sde_3549 1.26e-73 232.0 COG3807@1|root,COG3807@2|Bacteria,1RE8W@1224|Proteobacteria,1S4BU@1236|Gammaproteobacteria,46D3W@72275|Alteromonadaceae 1236|Gammaproteobacteria S Bacterial SH3 domain - - - - - - - - - - - - OMP_b-brl,SH3_3,SH3_4 k59_234216_3 443152.MDG893_05289 6.9e-85 281.0 COG0823@1|root,COG0823@2|Bacteria,1R3VN@1224|Proteobacteria,1RNKG@1236|Gammaproteobacteria,46408@72275|Alteromonadaceae 1236|Gammaproteobacteria U COG0823 Periplasmic component of the Tol biopolymer transport system - - - - - - - - - - - - PD40 k59_65616_1 1384049.CD29_07515 1.07e-38 141.0 COG1171@1|root,COG1171@2|Bacteria,1TP22@1239|Firmicutes,4HECI@91061|Bacilli,3IVXM@400634|Lysinibacillus 91061|Bacilli E Pyridoxal-phosphate dependent enzyme - - 4.3.1.19 ko:K01754 ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230 M00570 R00220,R00996 RC00418,RC02600 ko00000,ko00001,ko00002,ko01000 - - - PALP k59_1026077_1 316274.Haur_3629 2.02e-11 63.9 COG1073@1|root,COG1073@2|Bacteria,2G690@200795|Chloroflexi 200795|Chloroflexi S Alpha/beta hydrolase family - - - - - - - - - - - - Abhydrolase_5 k59_1026077_2 388467.A19Y_3359 3.19e-05 45.8 COG1225@1|root,COG1225@2|Bacteria,1G052@1117|Cyanobacteria,1HAIN@1150|Oscillatoriales 1117|Cyanobacteria O PFAM AhpC TSA family - - - - - - - - - - - - AhpC-TSA k59_1477812_1 765914.ThisiDRAFT_1511 4.87e-72 230.0 COG0079@1|root,COG0079@2|Bacteria,1MW7I@1224|Proteobacteria,1RP4T@1236|Gammaproteobacteria,1WX7G@135613|Chromatiales 135613|Chromatiales E Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily hisC2 - 2.6.1.9 ko:K00817 ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230 M00026 R00694,R00734,R03243 RC00006,RC00888 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 k59_1081926_1 1347342.BN863_33240 2.82e-14 73.2 COG1629@1|root,COG1629@2|Bacteria,COG4771@2|Bacteria,4NDX3@976|Bacteroidetes,1HY9Q@117743|Flavobacteriia 976|Bacteroidetes P TonB-dependent receptor - - - - - - - - - - - - CarbopepD_reg_2,Plug,TonB_dep_Rec k59_1081926_2 1178825.ALIH01000013_gene562 1.45e-88 277.0 COG0449@1|root,COG0449@2|Bacteria,4NE8Q@976|Bacteroidetes,1HX0U@117743|Flavobacteriia 976|Bacteroidetes M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source glmS - 2.6.1.16 ko:K00820 ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931 - R00768 RC00010,RC00163,RC02752 ko00000,ko00001,ko01000,ko01002 - - - GATase_6,SIS k59_177828_1 316407.4062803 1.4e-115 337.0 COG1752@1|root,COG1752@2|Bacteria,1MUM9@1224|Proteobacteria,1RRA1@1236|Gammaproteobacteria,3XQ8D@561|Escherichia 1236|Gammaproteobacteria S phosphatidylcholine metabolic process rssA GO:0003674,GO:0003824,GO:0016787 - ko:K07001 - - - - ko00000 - - - Patatin k59_1307996_2 1045855.DSC_12495 7.7e-36 136.0 COG0122@1|root,COG2169@1|root,COG0122@2|Bacteria,COG2169@2|Bacteria,1QTXM@1224|Proteobacteria,1RNQB@1236|Gammaproteobacteria,1X4AJ@135614|Xanthomonadales 135614|Xanthomonadales K AlkA N-terminal domain Ada - 3.2.2.21 ko:K13529 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03000,ko03400 - - - Ada_Zn_binding,AlkA_N,HTH_18,HhH-GPD k59_968629_1 316274.Haur_0047 1.75e-15 82.4 COG3552@1|root,COG3552@2|Bacteria,2G60I@200795|Chloroflexi,3757T@32061|Chloroflexia 32061|Chloroflexia S PFAM VWA containing CoxE family protein - - - ko:K07161 - - - - ko00000 - - - VWA_CoxE k59_291516_1 365046.Rta_02540 3.8e-39 147.0 COG0318@1|root,COG0764@1|root,COG0318@2|Bacteria,COG0764@2|Bacteria,1MXPB@1224|Proteobacteria,2VJ3A@28216|Betaproteobacteria,4ABEX@80864|Comamonadaceae 28216|Betaproteobacteria IQ AMP-binding enzyme - - - - - - - - - - - - AMP-binding,AMP-binding_C,FabA k59_1589964_1 1123258.AQXZ01000018_gene1007 2.58e-11 67.8 COG1020@1|root,COG1020@2|Bacteria,2GPHZ@201174|Actinobacteria,4FURZ@85025|Nocardiaceae 201174|Actinobacteria Q Belongs to the long-chain O-acyltransferase family - - - - - - - - - - - - DUF1298,WES_acyltransf k59_968636_1 1268237.G114_15656 9.85e-07 55.5 COG2902@1|root,COG2902@2|Bacteria,1MXNV@1224|Proteobacteria,1RQVZ@1236|Gammaproteobacteria,1Y5CD@135624|Aeromonadales 135624|Aeromonadales E Bacterial NAD-glutamate dehydrogenase - - 1.4.1.2 ko:K15371 ko00220,ko00250,ko00430,ko00910,ko01100,map00220,map00250,map00430,map00910,map01100 - R00243 RC00006,RC02799 ko00000,ko00001,ko01000 - - - Bac_GDH k59_968636_2 1121405.dsmv_0717 1.08e-13 73.6 COG0110@1|root,COG0110@2|Bacteria,1PHGJ@1224|Proteobacteria,4346I@68525|delta/epsilon subdivisions,2X9QW@28221|Deltaproteobacteria,2MP3M@213118|Desulfobacterales 28221|Deltaproteobacteria S Hexapeptide repeat of succinyl-transferase - - - - - - - - - - - - Hexapep k59_1420482_2 436308.Nmar_1350 2.6e-26 101.0 arCOG08684@1|root,arCOG08684@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_1420482_3 1229909.NSED_09385 1.65e-27 99.8 arCOG08748@1|root,arCOG08748@2157|Archaea,41SV7@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1026105_2 32057.KB217478_gene5442 8.75e-20 95.9 COG3210@1|root,COG3210@2|Bacteria,1G0EK@1117|Cyanobacteria,1HKYK@1161|Nostocales 1117|Cyanobacteria U TIGRFAM filamentous hemagglutinin family N-terminal domain - - - - - - - - - - - - Haemagg_act k59_460361_1 314345.SPV1_07366 1.83e-35 132.0 COG1262@1|root,COG1262@2|Bacteria,1MZ25@1224|Proteobacteria 1224|Proteobacteria D PFAM Formylglycine-generating sulfatase enzyme - - 1.14.99.50 ko:K18912 ko00340,map00340 - R11013 RC03323,RC03324 ko00000,ko00001,ko01000 - - - FGE-sulfatase k59_629821_1 926554.KI912668_gene5108 3.63e-18 84.7 COG0836@1|root,COG0836@2|Bacteria,1WIIC@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus M PFAM Nucleotidyl transferase - - 2.7.7.13 ko:K00971 ko00051,ko00520,ko01100,ko01110,map00051,map00520,map01100,map01110 M00114,M00361,M00362 R00885 RC00002 ko00000,ko00001,ko00002,ko01000 - - - MannoseP_isomer,NTP_transferase k59_1655087_1 1049564.TevJSym_au00560 1.86e-39 144.0 COG0585@1|root,COG0585@2|Bacteria,1MXHD@1224|Proteobacteria,1RPRF@1236|Gammaproteobacteria,1J50G@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs truD GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0016070,GO:0016853,GO:0016866,GO:0034641,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360 5.4.99.27 ko:K06176 - - - - ko00000,ko01000,ko03016 - - - TruD k59_1089456_1 1313172.YM304_26020 4.67e-102 310.0 COG0638@1|root,COG0638@2|Bacteria,2GMC6@201174|Actinobacteria,4CMS0@84992|Acidimicrobiia 84992|Acidimicrobiia F Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine pafA - 6.3.1.19 ko:K13571 - M00342 R11207 RC00090,RC00096 ko00000,ko00002,ko01000,ko03051 - - - Pup_ligase k59_73535_1 760192.Halhy_4759 3.11e-08 53.5 COG0098@1|root,COG0098@2|Bacteria,4NG1Z@976|Bacteroidetes,1IQ9B@117747|Sphingobacteriia 976|Bacteroidetes J Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body rpsE GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02988 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S5,Ribosomal_S5_C k59_73535_2 1110502.TMO_2614 9.41e-10 55.8 COG1841@1|root,COG1841@2|Bacteria,1PU2S@1224|Proteobacteria,2UF55@28211|Alphaproteobacteria,2JTU5@204441|Rhodospirillales 204441|Rhodospirillales J Ribosomal protein L30 rpmD - - ko:K02907 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L30 k59_73535_3 309803.CTN_1012 3.21e-14 69.3 COG0200@1|root,COG0200@2|Bacteria,2GD4I@200918|Thermotogae 200918|Thermotogae J binds to the 23S rRNA rplO GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - ko:K02876 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L27A k59_1655092_1 338966.Ppro_0024 1.91e-06 50.1 2AKQ6@1|root,2ZAYQ@2|Bacteria,1R429@1224|Proteobacteria,42NWN@68525|delta/epsilon subdivisions,2WMKI@28221|Deltaproteobacteria,43V14@69541|Desulfuromonadales 28221|Deltaproteobacteria S TIGRFAM MJ0042 family finger-like protein - - - - - - - - - - - - DUF3426,zinc_ribbon_4,zinc_ribbon_5 k59_1655092_2 1266914.ATUK01000011_gene2308 5.24e-16 80.1 COG0805@1|root,COG0805@2|Bacteria,1MVAY@1224|Proteobacteria,1RPRN@1236|Gammaproteobacteria,1WVX9@135613|Chromatiales 135613|Chromatiales U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides tatC - - ko:K03118 ko03060,ko03070,map03060,map03070 M00336 - - ko00000,ko00001,ko00002,ko02044 2.A.64 - - TatC k59_1541764_1 134676.ACPL_6886 2.15e-25 111.0 COG5001@1|root,COG5001@2|Bacteria,2GIZF@201174|Actinobacteria,4DAB5@85008|Micromonosporales 201174|Actinobacteria T signal transduction protein containing a membrane domain, an EAL and a GGDEF domain - - - - - - - - - - - - EAL,GGDEF,PAS_4 k59_524017_1 158500.BV97_00350 8.86e-105 314.0 COG4553@1|root,COG4553@2|Bacteria,1MVUH@1224|Proteobacteria,2TQXW@28211|Alphaproteobacteria,2K1W9@204457|Sphingomonadales 204457|Sphingomonadales I de-polymerase - - - - - - - - - - - - PHB_depo_C k59_1428162_1 1280952.HJA_02525 3.37e-104 306.0 COG2304@1|root,COG2304@2|Bacteria,1RBVD@1224|Proteobacteria,2UQGF@28211|Alphaproteobacteria,43XCY@69657|Hyphomonadaceae 28211|Alphaproteobacteria S von Willebrand factor (vWF) type A domain - - - - - - - - - - - - VWA k59_356019_1 1122138.AQUZ01000004_gene1003 3.18e-87 274.0 COG4653@1|root,COG4653@2|Bacteria,2HZB6@201174|Actinobacteria,4DVIV@85009|Propionibacteriales 201174|Actinobacteria OU Phage capsid family - - - - - - - - - - - - Phage_capsid k59_1372631_1 1442599.JAAN01000041_gene3127 4.02e-19 87.4 COG1252@1|root,COG1252@2|Bacteria,1MX96@1224|Proteobacteria,1RM9I@1236|Gammaproteobacteria,1X3HK@135614|Xanthomonadales 135614|Xanthomonadales C NADH dehydrogenase, FAD-containing subunit ndh - 1.6.99.3 ko:K03885 ko00190,map00190 - - - ko00000,ko00001,ko01000 - - - Pyr_redox_2 k59_1372631_2 1380394.JADL01000004_gene6065 4.04e-51 171.0 COG2227@1|root,COG2227@2|Bacteria,1QXTA@1224|Proteobacteria 1224|Proteobacteria H ubiE/COQ5 methyltransferase family - - - - - - - - - - - - Methyltransf_11 k59_864484_1 1178825.ALIH01000007_gene1633 3.39e-41 147.0 COG0801@1|root,COG1428@1|root,COG0801@2|Bacteria,COG1428@2|Bacteria,4NGE8@976|Bacteroidetes,1HWTH@117743|Flavobacteriia 976|Bacteroidetes FH Pfam 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK) folK - 2.7.6.3 ko:K00950 ko00790,ko01100,map00790,map01100 M00126,M00841 R03503 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - HPPK,dNK k59_467864_2 378806.STAUR_6949 4.18e-06 53.9 COG3291@1|root,COG3291@2|Bacteria 2|Bacteria S metallopeptidase activity - - - - - - - - - - - - DUF5011,F5_F8_type_C,LTD,MAM,PKD,PPC,Peptidase_M43,Peptidase_M9,Peptidase_M9_N,Peptidase_S8,fn3 k59_356025_1 1173028.ANKO01000014_gene1034 5.8e-15 79.7 COG4191@1|root,COG4191@2|Bacteria,1G0AZ@1117|Cyanobacteria,1H7MZ@1150|Oscillatoriales 1117|Cyanobacteria T Signal Transduction Histidine Kinase - - - - - - - - - - - - HATPase_c,HisKA,Response_reg k59_1655112_1 713586.KB900536_gene2146 4.99e-84 255.0 COG0708@1|root,COG0708@2|Bacteria,1MVII@1224|Proteobacteria,1RN4H@1236|Gammaproteobacteria,1WWV1@135613|Chromatiales 135613|Chromatiales L PFAM Endonuclease Exonuclease phosphatase - - 3.1.11.2 ko:K01142 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - Exo_endo_phos k59_1258866_2 187303.BN69_1179 9.38e-13 67.0 COG2759@1|root,COG2759@2|Bacteria,1MUR8@1224|Proteobacteria,2TRMM@28211|Alphaproteobacteria,36XKU@31993|Methylocystaceae 28211|Alphaproteobacteria F Formate--tetrahydrofolate ligase fhs - 6.3.4.3 ko:K01938 ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200 M00140,M00377 R00943 RC00026,RC00111 ko00000,ko00001,ko00002,ko01000 - - - FTHFS k59_16396_1 498211.CJA_0127 6.8e-40 152.0 COG3209@1|root,COG3210@1|root,COG3209@2|Bacteria,COG3210@2|Bacteria,1MVV1@1224|Proteobacteria,1RMPT@1236|Gammaproteobacteria,1FI4C@10|Cellvibrio 1236|Gammaproteobacteria M Insecticide toxin TcdB middle/N-terminal region - - - - - - - - - - - - RHS_repeat,SpvB,TcdB_toxin_midN,VCBS k59_1372646_1 1453501.JELR01000002_gene579 7.62e-57 199.0 COG0642@1|root,COG0784@1|root,COG1457@1|root,COG0784@2|Bacteria,COG1457@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,1RRGT@1236|Gammaproteobacteria,464VX@72275|Alteromonadaceae 1236|Gammaproteobacteria T COG0642 Signal transduction histidine kinase - - - - - - - - - - - - HATPase_c,HisKA,Response_reg k59_1541778_1 1122137.AQXF01000002_gene258 1.28e-53 180.0 COG5010@1|root,COG5010@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - TPR_16,TPR_19 k59_1372649_1 436308.Nmar_1086 3.34e-108 321.0 COG0505@1|root,arCOG00064@2157|Archaea,41SF0@651137|Thaumarchaeota 651137|Thaumarchaeota E carbamoyl-phosphate synthase, small subunit carA - 6.3.5.5 ko:K01956 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - - CPSase_sm_chain,GATase k59_1428177_1 247639.MGP2080_13153 2.5e-76 234.0 COG1028@1|root,COG1028@2|Bacteria,1NB6S@1224|Proteobacteria 1224|Proteobacteria IQ COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - - - - - - - - - - - adh_short_C2 k59_1428177_2 331869.BAL199_01524 1.27e-20 90.1 COG4221@1|root,COG4221@2|Bacteria,1QXEV@1224|Proteobacteria 1224|Proteobacteria S COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - 1.1.1.100 ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 k59_1202769_1 330084.JNYZ01000052_gene1466 1.63e-74 233.0 COG0274@1|root,COG0274@2|Bacteria,2GJIR@201174|Actinobacteria,4DYMF@85010|Pseudonocardiales 201174|Actinobacteria F Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate deoC - 4.1.2.4 ko:K01619 ko00030,map00030 - R01066 RC00436,RC00437 ko00000,ko00001,ko01000 - - - DeoC k59_241989_1 1347342.BN863_33230 5e-155 451.0 COG0449@1|root,COG0449@2|Bacteria,4NE8Q@976|Bacteroidetes,1HX0U@117743|Flavobacteriia 976|Bacteroidetes M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source glmS - 2.6.1.16 ko:K00820 ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931 - R00768 RC00010,RC00163,RC02752 ko00000,ko00001,ko01000,ko01002 - - - GATase_6,SIS k59_299410_2 157783.LK03_07610 3.95e-66 211.0 COG0002@1|root,COG0002@2|Bacteria,1MVJ6@1224|Proteobacteria,1RNMX@1236|Gammaproteobacteria 1236|Gammaproteobacteria E Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde argC GO:0003674,GO:0003824,GO:0003942,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016491,GO:0016620,GO:0016903,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.2.1.38 ko:K00145 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028,M00845 R03443 RC00684 ko00000,ko00001,ko00002,ko01000 - - iSSON_1240.SSON_4131 Semialdhyde_dh,Semialdhyde_dhC k59_467884_1 1033732.CAHI01000035_gene2790 2.46e-27 111.0 COG3385@1|root,COG3385@2|Bacteria,4NNZ7@976|Bacteroidetes 976|Bacteroidetes L Pfam Transposase DDE domain - - - - - - - - - - - - DDE_Tnp_1 k59_1598018_1 436308.Nmar_0178 6.69e-70 213.0 arCOG00516@1|root,arCOG00516@2157|Archaea,41T43@651137|Thaumarchaeota 651137|Thaumarchaeota S Pyridoxamine 5'-phosphate - - - - - - - - - - - - Putative_PNPOx k59_1598018_2 436308.Nmar_0177 5.23e-14 70.5 COG0436@1|root,arCOG01131@2157|Archaea,41S8G@651137|Thaumarchaeota 651137|Thaumarchaeota E DegT/DnrJ/EryC1/StrS aminotransferase family - - - - - - - - - - - - Aminotran_1_2 k59_807522_1 1089548.KI783301_gene238 5.16e-14 70.9 COG0064@1|root,COG0064@2|Bacteria,1TPG3@1239|Firmicutes,4HAFB@91061|Bacilli,3WDZI@539002|Bacillales incertae sedis 91061|Bacilli J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) gatB GO:0003674,GO:0003824,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564 6.3.5.6,6.3.5.7 ko:K02434 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - GatB_N,GatB_Yqey k59_807522_2 671143.DAMO_0810 5.2e-59 196.0 COG0154@1|root,COG0154@2|Bacteria,2NNSD@2323|unclassified Bacteria 2|Bacteria J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) gatA GO:0008150,GO:0040007 6.3.5.6,6.3.5.7 ko:K02433 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - Amidase k59_467889_1 716928.AJQT01000039_gene1468 1.05e-92 288.0 COG1116@1|root,COG1116@2|Bacteria,1MUDV@1224|Proteobacteria,2TSH9@28211|Alphaproteobacteria,4BAAI@82115|Rhizobiaceae 28211|Alphaproteobacteria P ABC transporter - - - ko:K02049,ko:K15555,ko:K15578 ko00910,ko00920,ko02010,map00910,map00920,map02010 M00188,M00436,M00438 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.16,3.A.1.16.1,3.A.1.17,3.A.1.17.2 - - ABC_tran k59_1598028_1 1120971.AUCA01000003_gene1464 1.37e-26 103.0 COG1117@1|root,COG1117@2|Bacteria,1TP1M@1239|Firmicutes,4HAB1@91061|Bacilli,277YK@186823|Alicyclobacillaceae 91061|Bacilli P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system pstB - 3.6.3.27 ko:K02036 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.7 - iSB619.SA_RS06920 ABC_tran k59_1598028_2 290315.Clim_0380 6.76e-08 55.8 COG0704@1|root,COG0704@2|Bacteria,1FEEN@1090|Chlorobi 1090|Chlorobi P Plays a role in the regulation of phosphate uptake - - - ko:K02039 - - - - ko00000 - - - PhoU k59_1089500_1 436308.Nmar_0326 4.49e-20 83.6 arCOG08780@1|root,arCOG08780@2157|Archaea,41T84@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1034060_1 887898.HMPREF0551_1704 2.87e-65 203.0 COG0757@1|root,COG0757@2|Bacteria,1RDDT@1224|Proteobacteria,2VR4Y@28216|Betaproteobacteria,1K5S0@119060|Burkholderiaceae 28216|Betaproteobacteria E Catalyzes a trans-dehydration via an enolate intermediate aroQ - 4.2.1.10 ko:K03786 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R03084 RC00848 ko00000,ko00001,ko00002,ko01000 - - - DHquinase_II k59_581124_2 996637.SGM_3603 9.59e-06 50.8 COG0006@1|root,COG0006@2|Bacteria,2GM7D@201174|Actinobacteria 201174|Actinobacteria E Belongs to the peptidase M24B family pepPI - 3.4.11.9 ko:K01262 - - - - ko00000,ko01000,ko01002 - - - AMP_N,Peptidase_M24 k59_356071_1 1323663.AROI01000020_gene780 2.43e-103 311.0 COG0683@1|root,COG0683@2|Bacteria,1MU8V@1224|Proteobacteria,1RMIJ@1236|Gammaproteobacteria 1236|Gammaproteobacteria E COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component - - - ko:K11959 ko02010,map02010 M00323 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4.4,3.A.1.4.5 - - Peripla_BP_5 k59_1315916_1 981223.AIED01000057_gene2655 8.33e-29 118.0 COG0399@1|root,COG0399@2|Bacteria,1MUMJ@1224|Proteobacteria,1RSDY@1236|Gammaproteobacteria,3NKKZ@468|Moraxellaceae 1236|Gammaproteobacteria M Putative transposase - - - - - - - - - - - - Y2_Tnp,Zn_Tnp_IS91 k59_411525_1 267608.RSp1637 2.22e-77 246.0 COG1609@1|root,COG1609@2|Bacteria,1MVUR@1224|Proteobacteria,2VJ85@28216|Betaproteobacteria,1K347@119060|Burkholderiaceae 28216|Betaproteobacteria K Transcription regulator - - - ko:K02529 - - - - ko00000,ko03000 - - - LacI,Peripla_BP_3 k59_807557_1 983920.Y88_0353 9.66e-94 286.0 COG1473@1|root,COG1473@2|Bacteria,1MUIV@1224|Proteobacteria,2TR5B@28211|Alphaproteobacteria,2K9Q2@204457|Sphingomonadales 204457|Sphingomonadales M Peptidase dimerisation domain - - - - - - - - - - - - M20_dimer,Peptidase_M20 k59_1202809_1 1385515.N791_07990 2.65e-50 169.0 COG1250@1|root,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,1RMZ8@1236|Gammaproteobacteria,1X486@135614|Xanthomonadales 135614|Xanthomonadales I 3-hydroxyacyl-coa dehydrogenase fadJ - 1.1.1.35,4.2.1.17,5.1.2.3 ko:K01782 ko00071,ko00280,ko00281,ko00310,ko00362,ko00380,ko00410,ko00640,ko00650,ko00903,ko00930,ko01040,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00362,map00380,map00410,map00640,map00650,map00903,map00930,map01040,map01100,map01110,map01120,map01130,map01200,map01212 M00032,M00087 R01975,R03026,R03045,R03276,R04137,R04170,R04203,R04204,R04224,R04737,R04738,R04739,R04740,R04741,R04744,R04745,R04746,R04748,R04749,R05066,R05305,R06411,R06412,R06941,R06942,R07935,R07951,R08093,R08094 RC00029,RC00099,RC00117,RC00241,RC00525,RC00831,RC00834,RC00896,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 - - - 3HCDH,3HCDH_N,ECH_1 k59_16470_1 1265503.KB905162_gene3650 1.68e-79 261.0 COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,1T234@1236|Gammaproteobacteria,2Q73E@267889|Colwelliaceae 1236|Gammaproteobacteria K Adenylate cyclase - - - - - - - - - - - - TPR_16 k59_637563_1 749927.AMED_2058 3.72e-50 176.0 COG0513@1|root,COG0513@2|Bacteria,2GIUR@201174|Actinobacteria,4DX9Q@85010|Pseudonocardiales 201174|Actinobacteria L DNA RNA helicase, superfamily II rhlE_2 - - - - - - - - - - - DEAD,Helicase_C k59_864554_1 399739.Pmen_1942 2.5e-37 129.0 COG0454@1|root,COG0456@2|Bacteria,1RA6D@1224|Proteobacteria,1TAUK@1236|Gammaproteobacteria,1YGK0@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria K Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_1 k59_1711034_1 247634.GPB2148_640 4.8e-66 216.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,1J4KP@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains glnG GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - ko:K07712 ko02020,map02020 M00497 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_637567_1 1380600.AUYN01000006_gene487 2.07e-122 353.0 COG2197@1|root,COG2197@2|Bacteria,4NHNP@976|Bacteroidetes,1I09Z@117743|Flavobacteriia 976|Bacteroidetes KT COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain - - - - - - - - - - - - Response_reg k59_637567_2 1131812.JQMS01000001_gene1108 1.46e-15 77.0 COG0457@1|root,COG4585@1|root,COG0457@2|Bacteria,COG4585@2|Bacteria,4NEPS@976|Bacteroidetes,1HYQ1@117743|Flavobacteriia,2NSA0@237|Flavobacterium 976|Bacteroidetes T Histidine kinase - - - - - - - - - - - - HATPase_c,HisKA_3,TPR_12,TPR_7,TPR_8 k59_1428253_1 383381.EH30_13215 1.03e-12 63.5 COG1815@1|root,COG1815@2|Bacteria,1MZ8P@1224|Proteobacteria,2UA68@28211|Alphaproteobacteria,2KDMA@204457|Sphingomonadales 204457|Sphingomonadales N Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body flgB - - ko:K02387 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - Flg_bb_rod k59_1428253_2 1096930.L284_06655 1.65e-09 57.8 COG1291@1|root,COG1291@2|Bacteria,1N0TR@1224|Proteobacteria,2UBP6@28211|Alphaproteobacteria,2K5AE@204457|Sphingomonadales 204457|Sphingomonadales U MotA/TolQ/ExbB proton channel family - - - ko:K02556 ko02020,ko02030,ko02040,map02020,map02030,map02040 - - - ko00000,ko00001,ko02000,ko02035 1.A.30.1 - - MotA_ExbB k59_1541845_1 1380394.JADL01000001_gene2522 2.76e-17 84.7 COG0028@1|root,COG0028@2|Bacteria,1MX6Q@1224|Proteobacteria,2TS3K@28211|Alphaproteobacteria,2JRPY@204441|Rhodospirillales 204441|Rhodospirillales EH Belongs to the TPP enzyme family mdlC - 4.1.1.7 ko:K01576 ko00627,ko01120,map00627,map01120 - R01764,R02672 RC00595 ko00000,ko00001,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_242058_1 913865.DOT_2689 6.78e-24 99.0 COG0041@1|root,COG0041@2|Bacteria,1V1MV@1239|Firmicutes,24HCB@186801|Clostridia,261MR@186807|Peptococcaceae 186801|Clostridia F Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) purE - 5.4.99.18 ko:K01588 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R07405 RC01947 ko00000,ko00001,ko00002,ko01000 - - - AIRC k59_242058_2 1210908.HSB1_04070 1.44e-20 90.9 COG0530@1|root,arCOG02881@2157|Archaea,2XVHN@28890|Euryarchaeota,241D1@183963|Halobacteria 183963|Halobacteria P Na Ca antiporter, CaCA family - - - ko:K07301 - - - - ko00000,ko02000 2.A.19.5 - - Na_Ca_ex k59_1428257_1 1198452.Jab_2c08620 6.87e-39 147.0 COG2208@1|root,COG4252@1|root,COG2208@2|Bacteria,COG4252@2|Bacteria,1QUNZ@1224|Proteobacteria,2WEJF@28216|Betaproteobacteria 28216|Betaproteobacteria T CHASE2 - - - - - - - - - - - - CHASE2,SpoIIE k59_1711046_1 1123393.KB891316_gene1172 1.97e-59 191.0 COG2854@1|root,COG2854@2|Bacteria,1NKFA@1224|Proteobacteria,2VR85@28216|Betaproteobacteria,1KRPH@119069|Hydrogenophilales 119069|Hydrogenophilales Q MlaC protein - - - ko:K07323 ko02010,map02010 M00210 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27.3 - - MlaC k59_807587_1 158500.BV97_03430 8.06e-74 231.0 COG1562@1|root,COG1562@2|Bacteria,1MX4W@1224|Proteobacteria,2TTI0@28211|Alphaproteobacteria,2K2BH@204457|Sphingomonadales 204457|Sphingomonadales I Phytoene synthase crtB - 2.5.1.32,2.5.1.99 ko:K02291 ko00906,ko01062,ko01100,ko01110,map00906,map01062,map01100,map01110 M00097 R02065,R04218,R07270,R10177 RC00362,RC01101,RC02869 ko00000,ko00001,ko00002,ko01000,ko01006 - - - SQS_PSY k59_807587_2 1096930.L284_00535 1.26e-07 51.6 COG1611@1|root,COG1611@2|Bacteria,1RD59@1224|Proteobacteria,2U5DP@28211|Alphaproteobacteria,2K0TW@204457|Sphingomonadales 204457|Sphingomonadales K Belongs to the LOG family - - 3.2.2.10 ko:K06966 ko00230,ko00240,map00230,map00240 - R00182,R00510 RC00063,RC00318 ko00000,ko00001,ko01000 - - - Lysine_decarbox k59_637577_1 502025.Hoch_1338 1.98e-33 120.0 2FGT4@1|root,348NF@2|Bacteria,1QAAV@1224|Proteobacteria,434Y1@68525|delta/epsilon subdivisions,2WZ8V@28221|Deltaproteobacteria,2Z1KQ@29|Myxococcales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_299473_1 171693.BN988_03739 2.22e-27 104.0 COG0346@1|root,COG0346@2|Bacteria,1V716@1239|Firmicutes,4HJJ4@91061|Bacilli 91061|Bacilli E bleomycin resistance protein - - - - - - - - - - - - Glyoxalase k59_299473_2 1148.1651703 4.57e-22 90.1 COG2318@1|root,COG2318@2|Bacteria,1G5EJ@1117|Cyanobacteria,1H6PR@1142|Synechocystis 1117|Cyanobacteria S DinB family - - - - - - - - - - - - DinB k59_920017_1 1122132.AQYH01000019_gene266 1.31e-12 68.9 COG0565@1|root,COG0565@2|Bacteria,1N47Y@1224|Proteobacteria,2TS8J@28211|Alphaproteobacteria,4B74Q@82115|Rhizobiaceae 28211|Alphaproteobacteria J Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA trmJ - - ko:K02533 - - - - ko00000,ko01000,ko03016 - - - DUF559,SpoU_methylase k59_920017_2 1122137.AQXF01000002_gene56 2.64e-75 232.0 2EMH2@1|root,33F5P@2|Bacteria,1NH3U@1224|Proteobacteria,2UMZ7@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_581180_1 1117647.M5M_15535 2.9e-55 187.0 COG2718@1|root,COG2718@2|Bacteria,1MWQM@1224|Proteobacteria,1RQWC@1236|Gammaproteobacteria,1J4X8@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Belongs to the UPF0229 family yeaH - - ko:K09786 - - - - ko00000 - - - DUF444 k59_1541866_1 395494.Galf_0060 7.61e-95 285.0 COG1013@1|root,COG1013@2|Bacteria,1MUY9@1224|Proteobacteria,2VKQX@28216|Betaproteobacteria 28216|Betaproteobacteria C PFAM Thiamine pyrophosphate porB - 1.2.1.58,1.2.7.1 ko:K00170,ko:K18356 ko00010,ko00020,ko00360,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00360,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200 M00173,M00307,M00374,M00620 R01196,R01199,R02450,R08034 RC00004,RC00250,RC02742,RC02833,RC02860 br01601,ko00000,ko00001,ko00002,ko01000 - - - Fer4_11,Fer4_6,TPP_enzyme_C k59_1485927_1 484019.THA_2040 8.38e-07 53.9 COG2801@1|root,COG2963@1|root,COG2801@2|Bacteria,COG2963@2|Bacteria,2GDHE@200918|Thermotogae 200918|Thermotogae L HTH-like domain - - - ko:K07497 - - - - ko00000 - - - HTH_21,HTH_Tnp_1,rve k59_1485927_2 997346.HMPREF9374_4040 3.25e-58 194.0 COG2801@1|root,COG2801@2|Bacteria,1TQQY@1239|Firmicutes,4HFFP@91061|Bacilli,27BYM@186824|Thermoactinomycetaceae 91061|Bacilli L Integrase core domain - - - - - - - - - - - - HTH_21,rve,rve_2 k59_1258971_1 436308.Nmar_0008 1.08e-89 276.0 COG1252@1|root,arCOG01067@2157|Archaea 2157|Archaea C COG1252 NADH dehydrogenase, FAD-containing subunit ndh2 - 1.6.99.3 ko:K03885 ko00190,map00190 - - - ko00000,ko00001,ko01000 - - - Pyr_redox_2 k59_187223_1 365046.Rta_18440 6.15e-82 257.0 COG0044@1|root,COG0044@2|Bacteria,1MW10@1224|Proteobacteria,2VJZV@28216|Betaproteobacteria,4ABSY@80864|Comamonadaceae 28216|Betaproteobacteria F PFAM amidohydrolase - - 3.5.2.2,3.5.2.5 ko:K01464,ko:K01466 ko00230,ko00240,ko00410,ko00770,ko00983,ko01100,ko01120,map00230,map00240,map00410,map00770,map00983,map01100,map01120 M00046,M00546 R02269,R02425,R03055,R08227 RC00632,RC00680 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Amidohydro_1 k59_300412_1 644966.Tmar_1403 1.71e-47 169.0 COG0277@1|root,COG0277@2|Bacteria,1TPBC@1239|Firmicutes,24A99@186801|Clostridia 186801|Clostridia C FAD linked oxidases, C-terminal domain - - 1.1.3.15 ko:K00104 ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130 - R00475 RC00042 ko00000,ko00001,ko01000 - - - FAD-oxidase_C,FAD_binding_4 k59_525016_1 1463825.JNXC01000003_gene3954 1.8e-18 89.4 COG0773@1|root,COG0773@2|Bacteria,2I2E7@201174|Actinobacteria,4DYX2@85010|Pseudonocardiales 201174|Actinobacteria M Belongs to the MurCDEF family murC GO:0000270,GO:0003674,GO:0003824,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008763,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0030203,GO:0034645,GO:0040007,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 6.3.2.8 ko:K01924 ko00471,ko00550,ko01100,map00471,map00550,map01100 - R03193 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_751527_1 1286631.X805_32920 1.69e-41 149.0 COG1835@1|root,COG1835@2|Bacteria,1RKTJ@1224|Proteobacteria,2VRZ5@28216|Betaproteobacteria 28216|Betaproteobacteria I PFAM acyltransferase 3 - - - - - - - - - - - - Acyl_transf_3 k59_751527_2 323848.Nmul_A2705 1.45e-09 57.4 COG2878@1|root,COG2878@2|Bacteria,1MUWU@1224|Proteobacteria,2VN5I@28216|Betaproteobacteria,3731C@32003|Nitrosomonadales 28216|Betaproteobacteria C Part of a membrane complex involved in electron transport rnfB - - ko:K03616 - - - - ko00000 - - - FeS,Fer4_21 k59_300414_1 760568.Desku_0435 7.61e-135 402.0 COG1053@1|root,COG1053@2|Bacteria,1TPAR@1239|Firmicutes,247SY@186801|Clostridia,2616M@186807|Peptococcaceae 186801|Clostridia C TIGRFAM succinate dehydrogenase or fumarate reductase, flavoprotein sdhA - 1.3.5.1,1.3.5.4 ko:K00239,ko:K00244 ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,ko05134,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020,map05134 M00009,M00011,M00149,M00150,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,Succ_DH_flav_C k59_1373668_1 330214.NIDE2515 2.02e-54 193.0 COG2982@1|root,COG2982@2|Bacteria 2|Bacteria M Protein involved in outer membrane biogenesis - - - ko:K07290 - - - - ko00000 9.B.121 - - AsmA,AsmA_2,DUF3971,DUF748 k59_1146966_1 765913.ThidrDRAFT_3296 7.16e-23 98.6 COG0188@1|root,COG0188@2|Bacteria,1MURI@1224|Proteobacteria,1RMTC@1236|Gammaproteobacteria,1WWE3@135613|Chromatiales 135613|Chromatiales L Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule parC - - ko:K02621 - - - - ko00000,ko01000,ko02048,ko03032,ko03036 - - - DNA_gyraseA_C,DNA_topoisoIV k59_1146966_2 472759.Nhal_0222 8.71e-08 53.9 COG0784@1|root,COG2199@1|root,COG2200@1|root,COG0784@2|Bacteria,COG2199@2|Bacteria,COG2200@2|Bacteria,1PJCA@1224|Proteobacteria,1RS4H@1236|Gammaproteobacteria,1WWNV@135613|Chromatiales 135613|Chromatiales T PFAM EAL domain - - - ko:K21025 ko02025,map02025 - - - ko00000,ko00001 - - - EAL,GGDEF,PAS,PAS_8,PAS_9,Response_reg k59_921132_3 985054.JQEZ01000001_gene2301 4.61e-08 54.7 COG0626@1|root,COG0626@2|Bacteria,1MU57@1224|Proteobacteria,2TTMF@28211|Alphaproteobacteria,4NA43@97050|Ruegeria 28211|Alphaproteobacteria E Catalyzes the formation of L-homocysteine from O- succinyl-L-homoserine (OSHS) and hydrogen sulfide metZ GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0003962,GO:0004123,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0016829,GO:0016846,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.5.1.48 ko:K01739,ko:K10764 ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00270,map00450,map00920,map01100,map01110,map01130,map01230 M00017 R00999,R01288,R02508,R03217,R03260,R04944,R04945,R04946 RC00020,RC00056,RC00069,RC00420,RC02848,RC02866 ko00000,ko00001,ko00002,ko01000 - - - Cys_Met_Meta_PP k59_1768593_1 1229909.NSED_07265 2.23e-47 154.0 COG1658@1|root,arCOG01486@2157|Archaea,41SU4@651137|Thaumarchaeota 651137|Thaumarchaeota L Toprim domain - - - - - - - - - - - - - k59_1768593_2 1229909.NSED_07270 8.56e-59 192.0 COG0334@1|root,arCOG01352@2157|Archaea,41S7T@651137|Thaumarchaeota 651137|Thaumarchaeota E Belongs to the Glu Leu Phe Val dehydrogenases family - - 1.4.1.3 ko:K00261 ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964 M00740 R00243,R00248 RC00006,RC02799 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ELFV_dehydrog,ELFV_dehydrog_N k59_983519_1 498211.CJA_2930 3.83e-69 222.0 COG0772@1|root,COG0772@2|Bacteria,1MVDB@1224|Proteobacteria,1RMIV@1236|Gammaproteobacteria,1FG9B@10|Cellvibrio 1236|Gammaproteobacteria M Peptidoglycan polymerase that is essential for cell division ftsW GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0008360,GO:0009987,GO:0015647,GO:0015648,GO:0015835,GO:0015836,GO:0016020,GO:0016021,GO:0022603,GO:0022604,GO:0022857,GO:0022884,GO:0031224,GO:0031226,GO:0032153,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0051179,GO:0051234,GO:0051301,GO:0055085,GO:0065007,GO:0065008,GO:0071702,GO:0071705,GO:0071944,GO:1901264,GO:1901505 - ko:K03588 ko04112,map04112 - - - ko00000,ko00001,ko02000,ko03036 2.A.103.1 - - FTSW_RODA_SPOVE k59_365745_1 1168065.DOK_03543 4.81e-15 72.0 COG3832@1|root,COG3832@2|Bacteria,1NKKP@1224|Proteobacteria,1SHSG@1236|Gammaproteobacteria,1JACX@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Protein of unknown function (DUF2505) - - - - - - - - - - - - DUF2505 k59_26156_1 690850.Desaf_0605 3.25e-28 109.0 COG4099@1|root,COG4099@2|Bacteria,1RHBS@1224|Proteobacteria,431BR@68525|delta/epsilon subdivisions,2WX0J@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Alpha/beta hydrolase family - - - - - - - - - - - - DLH k59_1212150_1 176652.289L_IIV6 1.26e-62 206.0 4QAPV@10239|Viruses,4QV7H@35237|dsDNA viruses no RNA stage 10239|Viruses S DNA binding - - - - - - - - - - - - - k59_251172_1 998674.ATTE01000001_gene3686 4.77e-118 348.0 COG1158@1|root,COG1158@2|Bacteria,1MUCF@1224|Proteobacteria,1RP95@1236|Gammaproteobacteria,45ZQQ@72273|Thiotrichales 72273|Thiotrichales K Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template rho - - ko:K03628 ko03018,map03018 - - - ko00000,ko00001,ko03019,ko03021 - - - ATP-synt_ab,Rho_N,Rho_RNA_bind k59_420247_2 521719.ATXQ01000002_gene2385 4.53e-33 134.0 COG2812@1|root,COG2812@2|Bacteria,1MVCK@1224|Proteobacteria,1RMIA@1236|Gammaproteobacteria,1YEVC@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria H DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity dnaX GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030234,GO:0030337,GO:0032991,GO:0034641,GO:0034645,GO:0042575,GO:0042802,GO:0043170,GO:0043846,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050790,GO:0061695,GO:0065007,GO:0065009,GO:0071704,GO:0090304,GO:0098772,GO:1901360,GO:1901576,GO:1902494,GO:1990234 2.7.7.7 ko:K02343 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_delta2,DNA_pol3_gamma3,DNA_pol3_tau_4,DNA_pol3_tau_5 k59_1154728_1 1121937.AUHJ01000001_gene474 1.44e-13 69.3 COG0493@1|root,COG1143@1|root,COG0493@2|Bacteria,COG1143@2|Bacteria,1MU2H@1224|Proteobacteria,1RMY7@1236|Gammaproteobacteria,464UQ@72275|Alteromonadaceae 1236|Gammaproteobacteria E COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductases - - 1.4.1.13,1.4.1.14 ko:K00266 ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 - R00093,R00114,R00248 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - DHODB_Fe-S_bind,Fer4_20,Fer4_7,NAD_binding_1,Pyr_redox_2 k59_1154728_2 83406.HDN1F_09550 1.35e-95 296.0 COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,1NBSJ@1224|Proteobacteria,1S0WV@1236|Gammaproteobacteria,1J5KF@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Pyruvate ferredoxin oxidoreductase and related 2-oxoacid ferredoxin oxidoreductases korA - 1.2.7.11,1.2.7.3 ko:K00174 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - PFOR_II,POR,POR_N k59_26178_1 436308.Nmar_1244 1.69e-83 258.0 COG0420@1|root,arCOG00397@2157|Archaea,41S68@651137|Thaumarchaeota 651137|Thaumarchaeota L Calcineurin-like phosphoesterase superfamily domain - - - ko:K03547 - - - - ko00000,ko03400 - - - Metallophos_2 k59_1608012_1 506534.Rhein_1575 2.9e-31 121.0 COG1835@1|root,COG1835@2|Bacteria,1MV2W@1224|Proteobacteria,1RQS2@1236|Gammaproteobacteria,1WY1F@135613|Chromatiales 135613|Chromatiales I PFAM Acyltransferase - - - - - - - - - - - - Acyl_transf_3 k59_531350_1 1392490.JHZX01000001_gene2018 8.48e-120 353.0 COG1593@1|root,COG1593@2|Bacteria,4NE5T@976|Bacteroidetes,1HX6G@117743|Flavobacteriia 976|Bacteroidetes G Tripartite ATP-independent periplasmic transporter, DctM component - - - - - - - - - - - - DctM k59_251196_1 158500.BV97_00778 6.24e-105 316.0 COG0442@1|root,COG0442@2|Bacteria,1MU7E@1224|Proteobacteria,2TQQ4@28211|Alphaproteobacteria,2K1F1@204457|Sphingomonadales 204457|Sphingomonadales J Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) proS - 6.1.1.15 ko:K01881 ko00970,map00970 M00359,M00360 R03661 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,tRNA-synt_2b k59_251196_2 1096930.L284_03310 0.000203 42.4 COG5394@1|root,COG5394@2|Bacteria,1RHRC@1224|Proteobacteria,2TQWQ@28211|Alphaproteobacteria,2K0W5@204457|Sphingomonadales 204457|Sphingomonadales S synthesis repressor PhaR phaR - - - - - - - - - - - PHB_acc,PHB_acc_N k59_365779_1 911045.PSE_3369 3.36e-80 247.0 COG0672@1|root,COG0672@2|Bacteria,1MXHM@1224|Proteobacteria,2VF5Q@28211|Alphaproteobacteria 28211|Alphaproteobacteria P PFAM Iron permease FTR1 - - - ko:K07243 - - - - ko00000,ko02000 2.A.108.1,2.A.108.2 - - FTR1 k59_475764_1 1304885.AUEY01000005_gene806 1.07e-21 89.7 COG0228@1|root,COG0228@2|Bacteria,1MZCT@1224|Proteobacteria,42V30@68525|delta/epsilon subdivisions,2WRH7@28221|Deltaproteobacteria,2MKIH@213118|Desulfobacterales 28221|Deltaproteobacteria J Belongs to the bacterial ribosomal protein bS16 family rpsP GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02959 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011,ko03029 - - - Ribosomal_S16 k59_475764_2 1379270.AUXF01000003_gene3580 9.42e-26 106.0 COG0541@1|root,COG0541@2|Bacteria,1ZSPG@142182|Gemmatimonadetes 142182|Gemmatimonadetes U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY ffh - 3.6.5.4 ko:K03106 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko01000,ko02044 3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9 - - SRP54,SRP54_N,SRP_SPB k59_1663331_1 62977.ACIAD1045 0.000948 40.8 COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,1MV6G@1224|Proteobacteria,1RMYD@1236|Gammaproteobacteria,3NJ8A@468|Moraxellaceae 1236|Gammaproteobacteria E B12 binding domain metH GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006464,GO:0006479,GO:0006520,GO:0006555,GO:0006575,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0008213,GO:0008270,GO:0008276,GO:0008652,GO:0008705,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0019538,GO:0019752,GO:0019842,GO:0031419,GO:0032259,GO:0034641,GO:0035999,GO:0036094,GO:0036211,GO:0042084,GO:0042558,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043414,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046653,GO:0046872,GO:0046906,GO:0046914,GO:0048037,GO:0050667,GO:0051186,GO:0071704,GO:0097159,GO:0140096,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.1.1.13 ko:K00548 ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230 M00017 R00946,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 - - iECO103_1326.ECO103_4764,iECUMN_1333.ECUMN_4545 B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans k59_1663331_2 1122137.AQXF01000005_gene1070 1.09e-127 370.0 COG1234@1|root,COG1234@2|Bacteria,1R64Z@1224|Proteobacteria,2TU6T@28211|Alphaproteobacteria 28211|Alphaproteobacteria S COG1234 Metal-dependent hydrolases of the beta-lactamase superfamily III - - - - - - - - - - - - Lactamase_B_2 k59_703756_1 1229909.NSED_06960 1.77e-38 135.0 arCOG08716@1|root,arCOG08716@2157|Archaea 1229909.NSED_06960|- - - - - - - - - - - - - - - - k59_365785_1 31964.CMS1818 1.43e-74 251.0 COG1530@1|root,COG1530@2|Bacteria,2GMM5@201174|Actinobacteria,4FM45@85023|Microbacteriaceae 201174|Actinobacteria J Ribonuclease E/G family rne - 3.1.26.12 ko:K08300,ko:K08301 ko03018,map03018 M00394 - - ko00000,ko00001,ko00002,ko01000,ko03009,ko03019 - - - IF2_N,RNase_E_G,S1 k59_927966_1 1415779.JOMH01000001_gene3285 2.46e-113 339.0 COG1622@1|root,COG1622@2|Bacteria,1MWHZ@1224|Proteobacteria,1RP4H@1236|Gammaproteobacteria,1X3IF@135614|Xanthomonadales 135614|Xanthomonadales C Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) ctaC - 1.9.3.1 ko:K02275 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.4,3.D.4.6 - - COX2,COX2_TM,Cytochrome_CBB3 k59_927966_2 550540.Fbal_0186 2.44e-19 87.4 COG0843@1|root,COG0843@2|Bacteria,1MU7S@1224|Proteobacteria,1RPC3@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B ctaD - 1.9.3.1 ko:K02274 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6 - iJN746.PP_0104 COX1 k59_1097713_1 1229909.NSED_07115 1.19e-78 263.0 COG2132@1|root,COG3391@1|root,COG3794@1|root,arCOG02562@2157|Archaea,arCOG02926@2157|Archaea,arCOG03914@2157|Archaea 2157|Archaea Q Multicopper - - - - - - - - - - - - Lactonase k59_1097713_2 436308.Nmar_1283 1.23e-44 150.0 COG0600@1|root,arCOG00169@2157|Archaea,41SIT@651137|Thaumarchaeota 651137|Thaumarchaeota P ABC-type nitrate sulfonate bicarbonate transport system, permease component - - - ko:K02050 - M00188 - - ko00000,ko00002,ko02000 3.A.1.16,3.A.1.17 - - BPD_transp_1 k59_475771_2 1229909.NSED_03755 2.62e-29 114.0 arCOG08797@1|root,arCOG08797@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_1495569_1 316407.85676998 2.41e-138 392.0 COG1309@1|root,COG1309@2|Bacteria,1RC4X@1224|Proteobacteria,1S20B@1236|Gammaproteobacteria 1236|Gammaproteobacteria K tetR family yjgJ GO:0000976,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0043565,GO:0044212,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2001141 - ko:K19335 - - - - ko00000,ko03000 - - - TetR_N k59_1382244_1 1306174.JODP01000005_gene1602 1.01e-79 258.0 COG1168@1|root,COG1168@2|Bacteria,2GJFQ@201174|Actinobacteria 201174|Actinobacteria E Aminotransferase, class I - - 4.4.1.8 ko:K14155 ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230 - R00782,R01286,R02408,R04941 RC00056,RC00069,RC00382,RC00488,RC00710,RC01245,RC02303 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_1_2,DUF664 k59_138931_1 1134474.O59_000209 1.08e-61 200.0 COG3852@1|root,COG3852@2|Bacteria,1MVN6@1224|Proteobacteria,1RN15@1236|Gammaproteobacteria,1FFTM@10|Cellvibrio 1236|Gammaproteobacteria T His Kinase A (phosphoacceptor) domain glnL GO:0000155,GO:0000160,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0004721,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0006464,GO:0006468,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016311,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0016787,GO:0016788,GO:0016791,GO:0018106,GO:0018193,GO:0018202,GO:0019222,GO:0019538,GO:0023014,GO:0023052,GO:0035556,GO:0036211,GO:0042578,GO:0042802,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0046777,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051716,GO:0065007,GO:0071704,GO:0140096,GO:1901564 2.7.13.3 ko:K07708 ko02020,map02020 M00497 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA,PAS,PAS_4 k59_138931_2 1027273.GZ77_18910 1.5e-22 97.1 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,1XI3Y@135619|Oceanospirillales 135619|Oceanospirillales T Response regulator of a two-component regulatory system involved in the activation of nitrogen assimilation genes glnG - - ko:K07712 ko02020,map02020 M00497 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_309000_1 395019.Bmul_1129 3.6e-74 243.0 COG0339@1|root,COG0339@2|Bacteria,1MU1K@1224|Proteobacteria,2VHPQ@28216|Betaproteobacteria,1K0UB@119060|Burkholderiaceae 28216|Betaproteobacteria E PFAM peptidase M3A and M3B, thimet oligopeptidase F prlC - 3.4.24.70 ko:K01414 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M3 k59_251222_1 392499.Swit_0728 2.09e-21 94.0 COG2303@1|root,COG2303@2|Bacteria,1MU3F@1224|Proteobacteria,2TT3C@28211|Alphaproteobacteria,2K0QC@204457|Sphingomonadales 204457|Sphingomonadales E Oxidoreductase - - 1.1.5.9 ko:K19813 ko00030,ko01100,ko01110,ko01130,map00030,map01100,map01110,map01130 - R00305 RC00066 ko00000,ko00001,ko01000 - - - FAD_binding_2,GMC_oxred_C,GMC_oxred_N,NAD_binding_8 k59_1382249_1 568768.CM001975_gene2485 4.15e-11 69.7 COG3297@1|root,COG3297@2|Bacteria,1NVVW@1224|Proteobacteria,1S01F@1236|Gammaproteobacteria,2JDBR@204037|Dickeya 1236|Gammaproteobacteria U Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins gspL - - ko:K02461 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - GspL_C,T2SSL k59_1436130_1 1192759.AKIB01000052_gene910 5.48e-194 547.0 COG0141@1|root,COG0141@2|Bacteria,1MUUF@1224|Proteobacteria,2TS04@28211|Alphaproteobacteria,2K1SZ@204457|Sphingomonadales 204457|Sphingomonadales E Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine - - 1.1.1.308 ko:K15509 - - - - ko00000,ko01000 - - - Histidinol_dh k59_1495578_1 316407.4062205 2.12e-133 406.0 COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,1SP6I@1236|Gammaproteobacteria,3XP8C@561|Escherichia 1236|Gammaproteobacteria P Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family cusA GO:0000041,GO:0003674,GO:0005215,GO:0005375,GO:0005488,GO:0005507,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006825,GO:0006873,GO:0006875,GO:0006878,GO:0006950,GO:0008150,GO:0008324,GO:0009636,GO:0009987,GO:0010035,GO:0010038,GO:0010272,GO:0010273,GO:0015075,GO:0015080,GO:0015318,GO:0015673,GO:0015679,GO:0016020,GO:0016021,GO:0019725,GO:0022857,GO:0022890,GO:0030001,GO:0030003,GO:0031224,GO:0034220,GO:0035434,GO:0042221,GO:0042592,GO:0043167,GO:0043169,GO:0044425,GO:0044464,GO:0046688,GO:0046872,GO:0046873,GO:0046914,GO:0046915,GO:0046916,GO:0048878,GO:0050801,GO:0050896,GO:0051179,GO:0051234,GO:0055065,GO:0055070,GO:0055076,GO:0055080,GO:0055082,GO:0055085,GO:0060003,GO:0061687,GO:0065007,GO:0065008,GO:0071944,GO:0097501,GO:0098655,GO:0098660,GO:0098662,GO:0098754,GO:0098771,GO:1902601,GO:1990169 - ko:K07787 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.6.1.4 - iB21_1397.B21_00525,iECBD_1354.ECBD_3087,iECB_1328.ECB_00536,iECD_1391.ECD_00536 ACR_tran k59_983568_1 377629.TERTU_3074 2.71e-64 208.0 COG5345@1|root,COG5345@2|Bacteria,1MWVH@1224|Proteobacteria,1RP5X@1236|Gammaproteobacteria,2PN6X@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria S Uncharacterized protein conserved in bacteria (DUF2333) - - - - - - - - - - - - DUF2333 k59_194060_1 1089551.KE386572_gene2577 1.87e-22 93.2 COG2802@1|root,COG2802@2|Bacteria,1NV9N@1224|Proteobacteria,2TQZ4@28211|Alphaproteobacteria,4BQ9E@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria S ATP-dependent protease La (LON) substrate-binding domain lonD - 3.4.21.53 ko:K01338,ko:K07157 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - LON_substr_bdg k59_194060_2 1122137.AQXF01000001_gene3354 9.19e-59 192.0 COG3118@1|root,COG3118@2|Bacteria,1MV0R@1224|Proteobacteria,2TS5X@28211|Alphaproteobacteria 28211|Alphaproteobacteria O Thioredoxin trxA2 - - ko:K03671,ko:K05838 ko04621,ko05418,map04621,map05418 - - - ko00000,ko00001,ko03110 - - - TPR_19,TPR_20,Thioredoxin k59_1495584_1 489825.LYNGBM3L_01970 1.06e-56 194.0 COG0659@1|root,COG0659@2|Bacteria,1G1F1@1117|Cyanobacteria,1H92U@1150|Oscillatoriales 1117|Cyanobacteria P Sulfate transporter - - - ko:K03321 - - - - ko00000,ko02000 2.A.53.3 - - STAS,Sulfate_transp k59_1212214_1 1229909.NSED_02465 9.83e-147 416.0 COG0007@1|root,arCOG00644@2157|Archaea,41S9J@651137|Thaumarchaeota 651137|Thaumarchaeota H Belongs to the precorrin methyltransferase family - - 2.1.1.107 ko:K02303 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R03194 RC00003,RC00871 ko00000,ko00001,ko00002,ko01000 - - - TP_methylase k59_1212214_2 436308.Nmar_0491 6.42e-50 167.0 COG0181@1|root,arCOG04299@2157|Archaea,41S6Z@651137|Thaumarchaeota 651137|Thaumarchaeota H Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps hemC - 2.5.1.61 ko:K01749 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R00084 RC02317 ko00000,ko00001,ko00002,ko01000 - - - Porphobil_deam,Porphobil_deamC k59_1720770_1 199310.c2573 2e-45 159.0 COG1109@1|root,COG1109@2|Bacteria,1MUA5@1224|Proteobacteria,1RMU8@1236|Gammaproteobacteria,3XN19@561|Escherichia 1236|Gammaproteobacteria F Involved in GDP-mannose biosynthesis which serves as the activated sugar nucleotide precursor for mannose residues in cell surface polysaccharides. This enzyme participates in synthesis of the LPS manB - 5.4.2.8 ko:K01840 ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130 M00114 R01818 RC00408 ko00000,ko00001,ko00002,ko01000 - - iECS88_1305.ECS88_2145,iECUMN_1333.ECUMN_2384,iUTI89_1310.UTI89_C2321 PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV k59_1720770_2 218491.ECA2329 4.22e-74 232.0 COG1210@1|root,COG1210@2|Bacteria,1MV5F@1224|Proteobacteria,1RNDX@1236|Gammaproteobacteria,1MQ84@122277|Pectobacterium 1236|Gammaproteobacteria M UTP-glucose-1-phosphate uridylyltransferase galU GO:0000271,GO:0000287,GO:0003674,GO:0003824,GO:0003983,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0005996,GO:0006011,GO:0006012,GO:0006073,GO:0006139,GO:0006629,GO:0006725,GO:0006793,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0009056,GO:0009058,GO:0009059,GO:0009103,GO:0009225,GO:0009242,GO:0009244,GO:0009250,GO:0009311,GO:0009312,GO:0009987,GO:0016043,GO:0016051,GO:0016052,GO:0016740,GO:0016772,GO:0016779,GO:0019318,GO:0019320,GO:0019388,GO:0022607,GO:0033499,GO:0033692,GO:0034637,GO:0034641,GO:0034645,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0043933,GO:0044042,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046377,GO:0046401,GO:0046483,GO:0046872,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0051748,GO:0055086,GO:0065003,GO:0070569,GO:0071704,GO:0071840,GO:1900725,GO:1900727,GO:1901135,GO:1901137,GO:1901360,GO:1901575,GO:1901576,GO:1903509 2.7.7.9 ko:K00963 ko00040,ko00052,ko00500,ko00520,ko01100,ko01130,map00040,map00052,map00500,map00520,map01100,map01130 M00129,M00361,M00362,M00549 R00289 RC00002 ko00000,ko00001,ko00002,ko01000 - - iECIAI39_1322.ECIAI39_1571 NTP_transferase k59_309026_1 1385519.N801_18290 1.71e-66 223.0 COG0022@1|root,COG1071@1|root,COG0022@2|Bacteria,COG1071@2|Bacteria,2GNII@201174|Actinobacteria,4FIVS@85021|Intrasporangiaceae 201174|Actinobacteria C Transketolase, pyrimidine binding domain - - 1.2.4.4 ko:K11381 ko00280,ko00640,ko01100,ko01110,ko01130,map00280,map00640,map01100,map01110,map01130 M00036 R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997 RC00027,RC00627,RC02743,RC02883,RC02949,RC02953 br01601,ko00000,ko00001,ko00002,ko01000 - - - E1_dh,Transket_pyr,Transketolase_C k59_1043951_1 717605.Theco_2138 6e-23 97.1 COG0331@1|root,COG0331@2|Bacteria,1TPB7@1239|Firmicutes,4HBCU@91061|Bacilli,26QJX@186822|Paenibacillaceae 91061|Bacilli I malonyl CoA-acyl carrier protein transacylase fabD - 2.3.1.39 ko:K00645 ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212 M00082 R01626,R11671 RC00004,RC00039,RC02727 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Acyl_transf_1 k59_1043951_2 1232410.KI421413_gene695 1.07e-15 70.9 COG0333@1|root,COG0333@2|Bacteria,1NGM1@1224|Proteobacteria,42XHF@68525|delta/epsilon subdivisions,2WSX6@28221|Deltaproteobacteria,43SSW@69541|Desulfuromonadales 28221|Deltaproteobacteria J structural constituent of ribosome rpmF GO:0003674,GO:0003735,GO:0005198 - ko:K02911 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011,ko03029 - - - Ribosomal_L32p k59_194069_1 225937.HP15_2344 1.7e-74 238.0 COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,1RNGU@1236|Gammaproteobacteria,4653T@72275|Alteromonadaceae 1236|Gammaproteobacteria I Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed fadI - 2.3.1.16,2.3.1.9 ko:K00626,ko:K00632 ko00071,ko00072,ko00280,ko00281,ko00310,ko00362,ko00380,ko00592,ko00620,ko00630,ko00640,ko00642,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00281,map00310,map00362,map00380,map00592,map00620,map00630,map00640,map00642,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00087,M00088,M00095,M00113,M00373,M00374,M00375 R00238,R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095 RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N k59_1382271_1 199310.c1511 8.79e-42 142.0 COG2915@1|root,COG2915@2|Bacteria,1RI8B@1224|Proteobacteria,1RPCC@1236|Gammaproteobacteria,3XMJX@561|Escherichia 1236|Gammaproteobacteria S Negative regulator of phage lambda lysogenization. Contributes to the degradation of the phage regulatory protein CII. Acts probably by holding CII on the membrane surface, away from the target promoters, but close to the FtsH protease hflD GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006950,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009898,GO:0016020,GO:0019897,GO:0019898,GO:0031234,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0071944,GO:0098552,GO:0098562 - ko:K07153 - - - - ko00000 - - - DUF489 k59_1382271_2 316407.1651559 1.05e-206 578.0 COG0015@1|root,COG0015@2|Bacteria,1MV4B@1224|Proteobacteria,1RN93@1236|Gammaproteobacteria,3XNCV@561|Escherichia 1236|Gammaproteobacteria F Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily purB GO:0003674,GO:0003824,GO:0004018,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0016829,GO:0016840,GO:0016842,GO:0033554,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716 4.3.2.2 ko:K01756 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048,M00049 R01083,R04559 RC00379,RC00444,RC00445 ko00000,ko00001,ko00002,ko01000 - - iAF1260.b1131,iBWG_1329.BWG_0979,iE2348C_1286.E2348C_1272,iEC042_1314.EC042_1202,iECABU_c1320.ECABU_c13450,iECDH10B_1368.ECDH10B_1203,iECP_1309.ECP_1126,iECUMN_1333.ECUMN_1375,iETEC_1333.ETEC_1255,iEcHS_1320.EcHS_A1251,iEcolC_1368.EcolC_2472,iJO1366.b1131,iJR904.b1131,iLF82_1304.LF82_1774,iNRG857_1313.NRG857_05460,iY75_1357.Y75_RS05905,ic_1306.c1510 ASL_C,Lyase_1 k59_1608075_1 768671.ThimaDRAFT_0368 1.12e-69 225.0 COG0247@1|root,COG0247@2|Bacteria,1MWTK@1224|Proteobacteria,1RQ9M@1236|Gammaproteobacteria,1WX1I@135613|Chromatiales 135613|Chromatiales C Cysteine-rich domain - - - - - - - - - - - - CCG k59_591983_2 83406.HDN1F_15630 1.39e-18 84.0 COG0045@1|root,COG0045@2|Bacteria,1MVCE@1224|Proteobacteria,1RMSU@1236|Gammaproteobacteria,1J53T@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria F Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit sucC GO:0003674,GO:0003824,GO:0004774,GO:0004775,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016874,GO:0016877,GO:0016878,GO:0016999,GO:0017144,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0055114,GO:0071704,GO:0072350 6.2.1.5,6.2.1.9 ko:K01903,ko:K14067 ko00020,ko00630,ko00640,ko00660,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00630,map00640,map00660,map00680,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00346,M00374,M00620 R00405,R01256,R02404 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000 - - - ATP-grasp_2,Ligase_CoA k59_984680_1 94624.Bpet3454 1.42e-60 197.0 COG2908@1|root,COG2908@2|Bacteria,1N3U7@1224|Proteobacteria,2VQRP@28216|Betaproteobacteria,3T1DM@506|Alcaligenaceae 28216|Betaproteobacteria S Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell lpxH - 3.6.1.54 ko:K03269 ko00540,ko01100,map00540,map01100 M00060 R04549 RC00002 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Metallophos,Metallophos_2 k59_421328_1 502025.Hoch_4506 1.24e-11 63.5 COG0359@1|root,COG0359@2|Bacteria,1RD0R@1224|Proteobacteria,42SCQ@68525|delta/epsilon subdivisions,2WPZQ@28221|Deltaproteobacteria,2YX0Q@29|Myxococcales 28221|Deltaproteobacteria J binds to the 23S rRNA rplI GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02939 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L9_C,Ribosomal_L9_N k59_1155964_1 1282362.AEAC466_13280 1.16e-56 203.0 COG1629@1|root,COG1629@2|Bacteria,COG4771@2|Bacteria,1MV8W@1224|Proteobacteria,2TSUV@28211|Alphaproteobacteria,2KHWB@204458|Caulobacterales 204458|Caulobacterales P TonB dependent receptor - - - - - - - - - - - - Plug,TonB_dep_Rec k59_1213644_1 946483.Cenrod_0945 1.22e-89 280.0 COG3288@1|root,COG3288@2|Bacteria,1MVXU@1224|Proteobacteria,2VJZN@28216|Betaproteobacteria,4A9YY@80864|Comamonadaceae 28216|Betaproteobacteria C The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane pntA - 1.6.1.2 ko:K00324 ko00760,ko01100,map00760,map01100 - R00112 RC00001 ko00000,ko00001,ko01000 - - - AlaDh_PNT_C,AlaDh_PNT_N,PNTB_4TM k59_84956_1 344747.PM8797T_10829 4.87e-42 152.0 COG1167@1|root,COG1167@2|Bacteria,2IY9J@203682|Planctomycetes 203682|Planctomycetes EK COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs - - - ko:K05825 ko00300,ko01100,ko01130,ko01210,map00300,map01100,map01130,map01210 - R01939 RC00006 ko00000,ko00001,ko01000 - - - Aminotran_1_2 k59_1213650_1 298655.KI912266_gene4028 1.49e-25 107.0 COG0778@1|root,COG0778@2|Bacteria,2I6AB@201174|Actinobacteria 201174|Actinobacteria C PFAM Nitroreductase - - - - - - - - - - - - Nitroreductase k59_1267990_1 63737.Npun_R0801 1.05e-35 134.0 COG3385@1|root,COG3385@2|Bacteria,1GQDD@1117|Cyanobacteria 1117|Cyanobacteria L transposase activity - - - - - - - - - - - - - k59_1553757_1 1007104.SUS17_2460 2.82e-57 201.0 COG1629@1|root,COG4771@2|Bacteria,1MVFB@1224|Proteobacteria,2U2UJ@28211|Alphaproteobacteria,2KEDN@204457|Sphingomonadales 204457|Sphingomonadales P TonB-dependent receptor plug - - - - - - - - - - - - Plug,TonB_dep_Rec k59_252716_1 436308.Nmar_0090 1.51e-94 283.0 COG1131@1|root,arCOG00194@2157|Archaea,41TB8@651137|Thaumarchaeota 651137|Thaumarchaeota E AAA domain, putative AbiEii toxin, Type IV TA system - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_1722346_1 1122194.AUHU01000004_gene1607 1.21e-41 142.0 COG0164@1|root,COG0164@2|Bacteria,1RA65@1224|Proteobacteria,1RQ4B@1236|Gammaproteobacteria,466FV@72275|Alteromonadaceae 1236|Gammaproteobacteria L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids rnhB GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006281,GO:0006298,GO:0006401,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0032299,GO:0032991,GO:0033554,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576 3.1.26.4 ko:K03470 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - RNase_HII k59_1722346_2 641147.HMPREF9021_01801 8.95e-09 58.2 COG0763@1|root,COG3266@1|root,COG0763@2|Bacteria,COG3266@2|Bacteria,1MVBI@1224|Proteobacteria,2VIBP@28216|Betaproteobacteria,2KPQB@206351|Neisseriales 206351|Neisseriales M Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell lpxB - 2.4.1.182 ko:K00748 ko00540,ko01100,map00540,map01100 M00060 R04606 RC00005,RC00059 ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT19 - LpxB k59_252718_1 240015.ACP_2928 2.3e-78 263.0 COG0085@1|root,COG0085@2|Bacteria,3Y36G@57723|Acidobacteria,2JIQM@204432|Acidobacteriia 204432|Acidobacteriia K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoB - 2.7.7.6 ko:K03043 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7 k59_984714_1 935548.KI912159_gene3858 9.73e-35 129.0 COG0604@1|root,COG0604@2|Bacteria,1MWZ1@1224|Proteobacteria,2U1CX@28211|Alphaproteobacteria 28211|Alphaproteobacteria C PFAM Alcohol dehydrogenase zinc-binding domain protein - - 1.6.5.5 ko:K00344 - - - - ko00000,ko01000 - - - ADH_zinc_N k59_984714_2 1031711.RSPO_c01868 2.89e-32 116.0 COG1846@1|root,COG1846@2|Bacteria,1RE7A@1224|Proteobacteria,2W76K@28216|Betaproteobacteria,1KDYE@119060|Burkholderiaceae 28216|Betaproteobacteria K helix_turn_helix multiple antibiotic resistance protein - - - - - - - - - - - - MarR k59_1155997_1 1484460.JSWG01000004_gene2630 6.12e-132 390.0 COG3743@1|root,COG5557@1|root,COG3743@2|Bacteria,COG5557@2|Bacteria,4NE3X@976|Bacteroidetes,1HY9P@117743|Flavobacteriia 976|Bacteroidetes C Polysulphide reductase nrfD - - ko:K00185 - - - - ko00000 5.A.3 - - NrfD k59_1155997_2 1249997.JHZW01000002_gene487 7.51e-10 57.4 COG2010@1|root,COG2010@2|Bacteria,4NEX9@976|Bacteroidetes,1HXN6@117743|Flavobacteriia,2PGVS@252356|Maribacter 976|Bacteroidetes C Protein of unknown function (DUF3341) actD - - - - - - - - - - - DUF3341 k59_1497202_1 402881.Plav_2205 6.92e-113 336.0 COG1960@1|root,COG1960@2|Bacteria,1MVJC@1224|Proteobacteria,2TUVB@28211|Alphaproteobacteria 28211|Alphaproteobacteria I acyl-CoA dehydrogenase MA20_22780 - 1.3.8.7 ko:K00249 ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320 M00013,M00036,M00087 R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754 RC00052,RC00068,RC00076,RC00095,RC00148,RC00246 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_984719_1 1123237.Salmuc_01346 2.46e-17 82.0 COG0589@1|root,COG0589@2|Bacteria,1PAFP@1224|Proteobacteria,2U0JA@28211|Alphaproteobacteria 28211|Alphaproteobacteria T COG0589 Universal stress protein UspA and related nucleotide-binding proteins - - - - - - - - - - - - Usp k59_984719_2 1040983.AXAE01000012_gene2275 2.06e-14 70.9 COG1846@1|root,COG1846@2|Bacteria,1NBQR@1224|Proteobacteria,2UGT1@28211|Alphaproteobacteria,43REK@69277|Phyllobacteriaceae 28211|Alphaproteobacteria K helix_turn_helix multiple antibiotic resistance protein - - - - - - - - - - - - HTH_27,MarR k59_1722368_1 76114.ebA5226 2.02e-32 125.0 COG3950@1|root,COG3950@2|Bacteria 2|Bacteria S AAA domain, putative AbiEii toxin, Type IV TA system - - - - - - - - - - - - AAA_15,AAA_21,AAA_23 k59_1722368_2 1211579.PP4_29920 1.41e-18 83.6 COG1403@1|root,COG1403@2|Bacteria,1N1B0@1224|Proteobacteria,1SJZQ@1236|Gammaproteobacteria 1236|Gammaproteobacteria V HNH endonuclease - - - - - - - - - - - - - k59_1268004_1 1122137.AQXF01000001_gene3400 4.88e-105 322.0 28IA1@1|root,2Z8CN@2|Bacteria,1QTRI@1224|Proteobacteria,2U31S@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_1268004_2 880070.Cycma_4814 3.78e-11 65.5 COG2271@1|root,COG2271@2|Bacteria,4NF82@976|Bacteroidetes,47M0P@768503|Cytophagia 976|Bacteroidetes G Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 k59_1383801_1 298654.FraEuI1c_5620 7.3e-23 105.0 COG3629@1|root,COG3903@1|root,COG3629@2|Bacteria,COG3903@2|Bacteria,2GIZ1@201174|Actinobacteria,4EUCA@85013|Frankiales 201174|Actinobacteria K transcriptional regulator, winged helix family - - - - - - - - - - - - BTAD,Guanylate_cyc,NB-ARC,Trans_reg_C k59_592055_1 1229909.NSED_05845 7.62e-83 267.0 COG0672@1|root,arCOG04330@2157|Archaea,41T07@651137|Thaumarchaeota 651137|Thaumarchaeota P High-affinity Fe2 Pb2 permease - - - ko:K07243 - - - - ko00000,ko02000 2.A.108.1,2.A.108.2 - - FTR1 k59_27922_1 1205680.CAKO01000040_gene723 3.68e-46 152.0 COG0599@1|root,COG0599@2|Bacteria,1RJU6@1224|Proteobacteria,2U5JQ@28211|Alphaproteobacteria,2JSN6@204441|Rhodospirillales 204441|Rhodospirillales S Carboxymuconolactone decarboxylase family - - - - - - - - - - - - CMD k59_27922_2 1049564.TevJSym_bb00030 7.3e-14 71.6 COG1013@1|root,COG1013@2|Bacteria,1R28U@1224|Proteobacteria 1224|Proteobacteria C 4fe-4S ferredoxin, iron-sulfur binding domain protein - - - - - - - - - - - - TPP_enzyme_C k59_1672507_1 395495.Lcho_1350 1.07e-113 340.0 COG2710@1|root,COG2710@2|Bacteria,1MWSX@1224|Proteobacteria,2VJNA@28216|Betaproteobacteria,1KKHN@119065|unclassified Burkholderiales 28216|Betaproteobacteria C Belongs to the NifD NifK NifE NifN family nifN - - ko:K02592 - - - - ko00000 - - - Oxidored_nitro k59_1275593_2 1185653.A1A1_15503 1.5e-91 295.0 COG2272@1|root,COG2272@2|Bacteria,1UXY5@1239|Firmicutes,4HCKV@91061|Bacilli,26HGA@186818|Planococcaceae 91061|Bacilli I Belongs to the type-B carboxylesterase lipase family pnbA - - ko:K03929 - - - - ko00000,ko01000 - CE10 - COesterase k59_1275593_3 1137268.AZXF01000004_gene2223 1.54e-28 113.0 28SI0@1|root,2ZEUB@2|Bacteria,2GNT0@201174|Actinobacteria,4EJEG@85012|Streptosporangiales 201174|Actinobacteria S Protein of unknown function (DUF2867) - - - - - - - - - - - - DUF2867 k59_205964_1 223192.XP_007919464.1 5.64e-13 74.7 28QPS@1|root,2QXCM@2759|Eukaryota,3A37T@33154|Opisthokonta,3P3IB@4751|Fungi,3QTFY@4890|Ascomycota,219F9@147550|Sordariomycetes 4751|Fungi E Phytanoyl-CoA dioxygenase (PhyH) - - - - - - - - - - - - PhyH k59_1107066_1 316407.85674343 4.4e-110 320.0 COG0842@1|root,COG0842@2|Bacteria,1MUH1@1224|Proteobacteria,1RP0Z@1236|Gammaproteobacteria,3XMRT@561|Escherichia 1236|Gammaproteobacteria V transmembrane transport yadH GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane k59_1332679_1 876044.IMCC3088_2132 1.17e-153 445.0 COG1228@1|root,COG1228@2|Bacteria,1MXXR@1224|Proteobacteria,1RRK7@1236|Gammaproteobacteria,1J7PK@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria Q COG1228 Imidazolonepropionase and related amidohydrolases - - - - - - - - - - - - Amidohydro_1,Amidohydro_3 k59_263173_2 266264.Rmet_2531 7.27e-33 125.0 COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,2VH9Y@28216|Betaproteobacteria,1K0HZ@119060|Burkholderiaceae 28216|Betaproteobacteria C acyl-CoA dehydrogenase - - 1.3.8.7 ko:K00249 ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320 M00013,M00036,M00087 R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754 RC00052,RC00068,RC00076,RC00095,RC00148,RC00246 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_484891_1 159087.Daro_3869 2.77e-45 160.0 COG0661@1|root,COG0661@2|Bacteria,1MU1Z@1224|Proteobacteria,2VJ07@28216|Betaproteobacteria,2KVNA@206389|Rhodocyclales 206389|Rhodocyclales H Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis ubiB - - ko:K03688 - - - - ko00000 - - - ABC1 k59_1107071_1 449447.MAE_09140 8.3e-20 81.3 COG1724@1|root,COG1724@2|Bacteria,1G8K9@1117|Cyanobacteria 1117|Cyanobacteria N PFAM YcfA-like protein - - - - - - - - - - - - HicA_toxin k59_1107071_2 880073.Calab_3411 1.69e-31 111.0 COG1598@1|root,COG1598@2|Bacteria,2NQ8D@2323|unclassified Bacteria 2|Bacteria S HicB_like antitoxin of bacterial toxin-antitoxin system - - - - - - - - - - - - HicB_lk_antitox k59_655076_1 1122137.AQXF01000001_gene3112 6.11e-55 178.0 COG2917@1|root,COG2917@2|Bacteria,1NWIZ@1224|Proteobacteria,2U74X@28211|Alphaproteobacteria 28211|Alphaproteobacteria D probably involved in intracellular septation ispZ - - ko:K06190 - - - - ko00000 - - - IspA k59_655076_2 1122137.AQXF01000001_gene3111 2.94e-127 374.0 COG2271@1|root,COG2271@2|Bacteria,1QV8S@1224|Proteobacteria,2TZ56@28211|Alphaproteobacteria 28211|Alphaproteobacteria G Transmembrane secretion effector - - - - - - - - - - - - MFS_3 k59_1054659_2 1168065.DOK_12301 4.84e-59 192.0 COG2159@1|root,COG2159@2|Bacteria,1MVHB@1224|Proteobacteria,1RMYJ@1236|Gammaproteobacteria,1J9DQ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S metal-dependent hydrolase of the TIM-barrel fold fldW - 4.1.1.45,4.2.1.83 ko:K03392,ko:K10220 ko00362,ko00380,ko01100,ko01120,map00362,map00380,map01100,map01120 M00038 R04323,R04478 RC00498,RC00779 ko00000,ko00001,ko00002,ko01000 - - - Amidohydro_2 k59_1618205_1 278957.ABEA03000110_gene1309 9.2e-25 110.0 COG2211@1|root,COG2211@2|Bacteria,46Y3F@74201|Verrucomicrobia,3K8VH@414999|Opitutae 414999|Opitutae G MFS/sugar transport protein - - - ko:K03292 - - - - ko00000 2.A.2 - - MFS_2 k59_206020_1 745014.OMB55_00021440 3.61e-86 280.0 COG4774@1|root,COG4774@2|Bacteria,1MX2G@1224|Proteobacteria,1RYSK@1236|Gammaproteobacteria,1J7TN@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P COG1629 Outer membrane receptor proteins, mostly Fe transport - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_38550_1 247633.GP2143_16281 9.62e-25 95.5 2E7KC@1|root,3322E@2|Bacteria,1NBFM@1224|Proteobacteria,1SDU2@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Multidrug transporter - - - - - - - - - - - - - k59_38550_2 498211.CJA_3503 8.35e-77 233.0 COG0669@1|root,COG0669@2|Bacteria,1RD9F@1224|Proteobacteria,1S41J@1236|Gammaproteobacteria,1FGMI@10|Cellvibrio 1236|Gammaproteobacteria H Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate coaD GO:0003674,GO:0003824,GO:0004595,GO:0005488,GO:0005515,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0070566,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.7.3 ko:K00954 ko00770,ko01100,map00770,map01100 M00120 R03035 RC00002 ko00000,ko00001,ko00002,ko01000 - - iPC815.YPO0053,iSDY_1059.SDY_4064 CTP_transf_like k59_1222602_1 1049564.TevJSym_af00690 4.95e-14 70.9 COG1028@1|root,COG3347@1|root,COG1028@2|Bacteria,COG3347@2|Bacteria,1MWSB@1224|Proteobacteria,1RNTD@1236|Gammaproteobacteria,1J9TP@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria IQ Class II Aldolase and Adducin N-terminal domain - - - - - - - - - - - - Aldolase_II,adh_short_C2 k59_1222602_2 156889.Mmc1_1944 3.44e-23 99.8 COG0182@1|root,COG0182@2|Bacteria,1MUPM@1224|Proteobacteria,2U6SW@28211|Alphaproteobacteria 28211|Alphaproteobacteria J Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P) - - 5.3.1.23 ko:K08963 ko00270,ko01100,map00270,map01100 M00034 R04420 RC01151 ko00000,ko00001,ko00002,ko01000 - - - IF-2B k59_148367_1 1096930.L284_14650 3.27e-100 318.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2TQS3@28211|Alphaproteobacteria,2K0SK@204457|Sphingomonadales 204457|Sphingomonadales T Putative diguanylate phosphodiesterase - - - - - - - - - - - - EAL,GGDEF,MHYT,PAS,PAS_7,PAS_9 k59_206028_1 316407.85676378 1.7e-121 362.0 COG1001@1|root,COG1001@2|Bacteria,1MVFP@1224|Proteobacteria,1RYZ1@1236|Gammaproteobacteria,3XPH7@561|Escherichia 1236|Gammaproteobacteria F adenine deaminase ade GO:0000034,GO:0003674,GO:0003824,GO:0004096,GO:0004601,GO:0005488,GO:0005506,GO:0006040,GO:0006044,GO:0006046,GO:0006139,GO:0006144,GO:0006145,GO:0006146,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008198,GO:0008448,GO:0009056,GO:0009058,GO:0009112,GO:0009113,GO:0009636,GO:0009987,GO:0016209,GO:0016491,GO:0016684,GO:0016787,GO:0016810,GO:0016811,GO:0016814,GO:0018130,GO:0019213,GO:0019239,GO:0019438,GO:0019439,GO:0030145,GO:0034641,GO:0042221,GO:0042440,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0046083,GO:0046100,GO:0046101,GO:0046112,GO:0046113,GO:0046148,GO:0046348,GO:0046483,GO:0046700,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0055086,GO:0055114,GO:0070887,GO:0071704,GO:0072521,GO:0072522,GO:0072523,GO:0097237,GO:0098754,GO:0098869,GO:1901071,GO:1901072,GO:1901135,GO:1901136,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1990748 3.5.4.2 ko:K01486 ko00230,ko01100,map00230,map01100 - R01244 RC00477 ko00000,ko00001,ko01000 - - iECUMN_1333.ECUMN_4192,iSFV_1184.SFV_3844 Adenine_deam_C,Amidohydro_1 k59_716220_1 794903.OPIT5_05350 6.24e-63 210.0 COG0173@1|root,COG0173@2|Bacteria,46S7W@74201|Verrucomicrobia,3K79T@414999|Opitutae 414999|Opitutae J Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) aspS - 6.1.1.12 ko:K01876 ko00970,map00970 M00359,M00360 R05577 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - GAD,tRNA-synt_2,tRNA_anti-codon k59_767245_1 288000.BBta_5540 5.04e-25 101.0 COG2062@1|root,COG2062@2|Bacteria,1N0FX@1224|Proteobacteria,2UBYD@28211|Alphaproteobacteria,3JSQ3@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria T Histidine phosphatase superfamily (branch 1) sixA - - ko:K08296 - - - - ko00000,ko01000 - - - His_Phos_1 k59_767245_2 1173023.KE650771_gene4626 1.07e-07 56.2 COG0457@1|root,COG0457@2|Bacteria,1G5P9@1117|Cyanobacteria,1JIH2@1189|Stigonemataceae 1117|Cyanobacteria S Tetratricopeptide repeat - - - - - - - - - - - - TPR_1,TPR_16,TPR_2,TPR_6,TPR_8 k59_1054703_1 1207063.P24_08624 1.14e-59 195.0 COG1309@1|root,COG1309@2|Bacteria,1RDM7@1224|Proteobacteria,2U83S@28211|Alphaproteobacteria,2JZP6@204441|Rhodospirillales 204441|Rhodospirillales K BetI-type transcriptional repressor, C-terminal - - - - - - - - - - - - TetR_C_6,TetR_N k59_1618218_1 285514.JNWO01000002_gene5508 7.08e-48 170.0 COG0654@1|root,COG0654@2|Bacteria,2GK88@201174|Actinobacteria 201174|Actinobacteria CH PFAM monooxygenase FAD-binding mhpA - 1.14.13.219 ko:K20943 ko00362,ko01120,map00362,map01120 - R05249 RC00046 ko00000,ko00001,ko01000 - - - FAD_binding_3 k59_1508687_1 203122.Sde_0773 6.79e-74 227.0 COG0235@1|root,COG0235@2|Bacteria,1MU54@1224|Proteobacteria,1RMIP@1236|Gammaproteobacteria,4642V@72275|Alteromonadaceae 1236|Gammaproteobacteria G Class II Aldolase and Adducin N-terminal domain araD GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008270,GO:0008742,GO:0009056,GO:0009058,GO:0009987,GO:0016052,GO:0016829,GO:0016830,GO:0016832,GO:0016853,GO:0016854,GO:0016857,GO:0019321,GO:0019323,GO:0019324,GO:0019566,GO:0019568,GO:0019569,GO:0019572,GO:0019637,GO:0019752,GO:0019852,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046373,GO:0046872,GO:0046914,GO:0051167,GO:0051186,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901159,GO:1901575,GO:1901576 5.1.3.4 ko:K03077 ko00040,ko00053,ko01100,ko01120,map00040,map00053,map01100,map01120 M00550 R05850 RC01479 ko00000,ko00001,ko00002,ko01000 - - iECO111_1330.ECO111_4403,iLF82_1304.LF82_2127,iNRG857_1313.NRG857_17845,iSDY_1059.SDY_4367,iSSON_1240.SSON_0067 Aldolase_II k59_1508687_2 1123236.KB899383_gene2661 3.88e-08 53.9 COG2160@1|root,COG2160@2|Bacteria,1MW0J@1224|Proteobacteria,1RQEF@1236|Gammaproteobacteria,4669F@72275|Alteromonadaceae 1236|Gammaproteobacteria G L-arabinose isomerase C-terminal domain araA GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008733,GO:0009056,GO:0009058,GO:0009987,GO:0016052,GO:0016853,GO:0016860,GO:0016861,GO:0019321,GO:0019323,GO:0019566,GO:0019568,GO:0019569,GO:0019572,GO:0019637,GO:0044237,GO:0044238,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046373,GO:0051167,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901159,GO:1901575,GO:1901576 5.3.1.4 ko:K01804 ko00040,ko01100,map00040,map01100 - R01761 RC00516 ko00000,ko00001,ko01000 - - iAPECO1_1312.APECO1_1922,iB21_1397.B21_00063,iBWG_1329.BWG_0058,iE2348C_1286.E2348C_0063,iECBD_1354.ECBD_3555,iECD_1391.ECD_00064,iECED1_1282.ECED1_0061,iECIAI1_1343.ECIAI1_0062,iECNA114_1301.ECNA114_0050,iECO103_1326.ECO103_0063,iECO26_1355.ECO26_0064,iECOK1_1307.ECOK1_0061,iECP_1309.ECP_0063,iECS88_1305.ECS88_0065,iECSE_1348.ECSE_0062,iECW_1372.ECW_m0060,iEKO11_1354.EKO11_3852,iEcE24377_1341.EcE24377A_0064,iEcHS_1320.EcHS_A0066,iEcSMS35_1347.EcSMS35_0064,iEcolC_1368.EcolC_3595,iLF82_1304.LF82_0105,iNRG857_1313.NRG857_00320,iSBO_1134.SBO_0049,iSSON_1240.SSON_0068,iUMN146_1321.UM146_23095,iUTI89_1310.UTI89_C0067,iWFL_1372.ECW_m0060 Arabinose_Iso_C,Arabinose_Isome k59_1055724_1 189753.AXAS01000008_gene6622 1.1e-38 138.0 COG1651@1|root,COG1651@2|Bacteria,1MX2T@1224|Proteobacteria,2TRAG@28211|Alphaproteobacteria,3JSDD@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria O Thioredoxin MA20_20720 - - - - - - - - - - - DSBA,Thioredoxin_4 k59_656102_1 436308.Nmar_1290 6.12e-99 293.0 COG0548@1|root,arCOG00862@2157|Archaea,41SFB@651137|Thaumarchaeota 651137|Thaumarchaeota E Involved in both the arginine and lysine biosynthetic pathways. Phosphorylates the LysW-bound precursors glutamate (for arginine biosynthesis), respectively alpha-aminoadipate (for lysine biosynthesis) lysZ - - ko:K05828 ko00220,ko00300,ko01100,ko01110,ko01210,ko01230,map00220,map00300,map01100,map01110,map01210,map01230 M00031,M00763 R09776,R10930 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase k59_656102_2 1229909.NSED_07155 2.11e-249 684.0 COG0002@1|root,arCOG00495@2157|Archaea,41S8R@651137|Thaumarchaeota 651137|Thaumarchaeota E Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. LysY sub-subfamily lysY - - ko:K05829 ko00220,ko00300,ko01100,ko01110,ko01210,ko01230,map00220,map00300,map01100,map01110,map01210,map01230 M00031,M00763 R09777,R10931 RC00684 ko00000,ko00001,ko00002,ko01000 - - - Semialdhyde_dh,Semialdhyde_dhC k59_656102_3 1229909.NSED_07150 5.47e-29 110.0 COG0189@1|root,arCOG01589@2157|Archaea,41SCQ@651137|Thaumarchaeota 651137|Thaumarchaeota H Lysine biosynthesis - - 6.3.2.43 ko:K05827 ko00300,ko01100,ko01210,ko01230,map00300,map01100,map01210,map01230 M00031 R09775 RC00064,RC00090 ko00000,ko00001,ko00002,ko01000 - - - RimK k59_1395836_1 1122137.AQXF01000004_gene1695 1.19e-07 53.5 COG0706@1|root,COG0706@2|Bacteria,1MV5M@1224|Proteobacteria,2TSTJ@28211|Alphaproteobacteria 28211|Alphaproteobacteria U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins yidC GO:0002790,GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0008565,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0032940,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944 - ko:K03217 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044,ko03029 2.A.9 - - 60KD_IMP,YidC_periplas k59_1395836_2 1122137.AQXF01000004_gene1696 1.61e-34 122.0 COG0759@1|root,COG0759@2|Bacteria,1N6U4@1224|Proteobacteria,2UFKH@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Could be involved in insertion of integral membrane proteins into the membrane yidD - - ko:K08998 - - - - ko00000 - - - Haemolytic k59_1395836_3 1122137.AQXF01000004_gene1697 3.76e-20 84.3 COG0594@1|root,COG0594@2|Bacteria,1N6QY@1224|Proteobacteria,2UFAB@28211|Alphaproteobacteria 28211|Alphaproteobacteria J RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme rnpA - 3.1.26.5 ko:K03536 - - - - ko00000,ko01000,ko03016 - - - Ribonuclease_P k59_1508701_2 69395.JQLZ01000001_gene3328 8.19e-131 394.0 COG2234@1|root,COG2234@2|Bacteria,1MV86@1224|Proteobacteria,2TVJ5@28211|Alphaproteobacteria,2KF25@204458|Caulobacterales 204458|Caulobacterales S peptidase - - - - - - - - - - - - PA,Peptidase_M28 k59_264297_2 1232437.KL661966_gene3135 1e-40 153.0 COG1104@1|root,COG1104@2|Bacteria,1MU1C@1224|Proteobacteria,42M5V@68525|delta/epsilon subdivisions,2WIR6@28221|Deltaproteobacteria,2MHW4@213118|Desulfobacterales 28221|Deltaproteobacteria E Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine nifS-1 - 2.8.1.7 ko:K04487 ko00730,ko01100,ko04122,map00730,map01100,map04122 - R07460,R11528,R11529 RC01789,RC02313 ko00000,ko00001,ko01000,ko02048,ko03016,ko03029 - - - Aminotran_5 k59_149581_1 1379270.AUXF01000001_gene2009 1.71e-84 268.0 COG0515@1|root,COG0515@2|Bacteria,1ZUBQ@142182|Gemmatimonadetes 142182|Gemmatimonadetes KLT Protein kinase domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase k59_1395858_1 1122137.AQXF01000003_gene2008 8.18e-104 327.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,2TQR7@28211|Alphaproteobacteria 28211|Alphaproteobacteria T methyl-accepting chemotaxis protein - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - HAMP,MCPsignal,Protoglobin k59_827305_1 511145.b0727 8.52e-126 367.0 COG0508@1|root,COG0508@2|Bacteria,1MUJD@1224|Proteobacteria,1RME0@1236|Gammaproteobacteria,3XP92@561|Escherichia 1236|Gammaproteobacteria C The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) sucB GO:0003674,GO:0003824,GO:0004149,GO:0005488,GO:0005504,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0008289,GO:0009060,GO:0009987,GO:0015980,GO:0016417,GO:0016740,GO:0016746,GO:0016747,GO:0016748,GO:0016751,GO:0016999,GO:0017144,GO:0019752,GO:0031405,GO:0031406,GO:0032991,GO:0033293,GO:0036094,GO:0043167,GO:0043168,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045239,GO:0045240,GO:0045252,GO:0045333,GO:0048037,GO:0050662,GO:0055114,GO:0071704,GO:0072350,GO:0097159,GO:0140096,GO:1901363,GO:1901681,GO:1902494,GO:1990204,GO:1990234 2.3.1.61 ko:K00658 ko00020,ko00310,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00032 R02570,R02571,R08549 RC00004,RC02727,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - iAPECO1_1312.APECO1_1352,iECED1_1282.ECED1_0696,iECOK1_1307.ECOK1_0726,iECS88_1305.ECS88_0752,iLF82_1304.LF82_2196,iNRG857_1313.NRG857_03235,iUMN146_1321.UM146_13990,iUTI89_1310.UTI89_C0722 2-oxoacid_dh,Biotin_lipoyl,E3_binding k59_1731739_2 713586.KB900536_gene2316 2.16e-11 63.9 COG1192@1|root,COG1192@2|Bacteria,1QBJX@1224|Proteobacteria,1S739@1236|Gammaproteobacteria 1236|Gammaproteobacteria D involved in chromosome partitioning - - - ko:K03496 - - - - ko00000,ko03036,ko04812 - - - AAA_31,CbiA k59_1619226_1 1219045.BV98_000860 2.49e-158 462.0 COG3119@1|root,COG3119@2|Bacteria,1MV0B@1224|Proteobacteria,2TRI6@28211|Alphaproteobacteria,2KCQN@204457|Sphingomonadales 204457|Sphingomonadales P Domain of unknown function (DUF4976) - - - - - - - - - - - - DUF4976,Sulfatase k59_656148_1 279238.Saro_0146 3.08e-124 354.0 COG0717@1|root,COG0717@2|Bacteria,1MV2J@1224|Proteobacteria,2TSDM@28211|Alphaproteobacteria,2JZVF@204457|Sphingomonadales 204457|Sphingomonadales F Belongs to the dCTP deaminase family dcd - 3.5.4.13 ko:K01494 ko00240,ko01100,map00240,map01100 M00053 R00568,R02325 RC00074 ko00000,ko00001,ko00002,ko01000 - - - dUTPase k59_1731741_1 56110.Oscil6304_4169 1.16e-31 116.0 COG0283@1|root,COG0414@1|root,COG0283@2|Bacteria,COG0414@2|Bacteria,1G1BX@1117|Cyanobacteria,1H7SQ@1150|Oscillatoriales 1117|Cyanobacteria F Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate panC/cmk GO:0003674,GO:0003824,GO:0004127,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006573,GO:0006575,GO:0006725,GO:0006732,GO:0006753,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009117,GO:0009123,GO:0009165,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0034654,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046939,GO:0046940,GO:0050145,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.7.4.25,6.3.2.1 ko:K13799 ko00240,ko00410,ko00770,ko01100,ko01110,map00240,map00410,map00770,map01100,map01110 M00052,M00119 R00158,R00512,R01665,R02473 RC00002,RC00096,RC00141 ko00000,ko00001,ko00002,ko01000 - - - Cytidylate_kin,Pantoate_ligase k59_207100_1 1380390.JIAT01000012_gene2939 2.87e-79 258.0 COG2303@1|root,COG2303@2|Bacteria,2GJAU@201174|Actinobacteria,4CSB6@84995|Rubrobacteria 84995|Rubrobacteria E GMC oxidoreductase - - - - - - - - - - - - GMC_oxred_C,GMC_oxred_N k59_207100_2 1133849.O3I_027895 7.43e-54 180.0 COG0604@1|root,COG0604@2|Bacteria,2GKHW@201174|Actinobacteria,4FVZS@85025|Nocardiaceae 201174|Actinobacteria C Zinc-binding dehydrogenase qor - 1.6.5.5 ko:K00344 - - - - ko00000,ko01000 - - - ADH_N,ADH_zinc_N k59_1566249_1 511145.b2010 2.37e-139 401.0 COG1686@1|root,COG1686@2|Bacteria,1MUU7@1224|Proteobacteria,1RMJA@1236|Gammaproteobacteria,3XP01@561|Escherichia 1236|Gammaproteobacteria M Belongs to the peptidase S11 family dacA GO:0000270,GO:0003674,GO:0003824,GO:0004175,GO:0004180,GO:0004185,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006022,GO:0006023,GO:0006024,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0008238,GO:0008360,GO:0008658,GO:0009002,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016021,GO:0016787,GO:0017171,GO:0019538,GO:0022603,GO:0022604,GO:0030203,GO:0031224,GO:0031226,GO:0031406,GO:0033218,GO:0033293,GO:0034645,GO:0036094,GO:0042221,GO:0042493,GO:0042546,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051128,GO:0065007,GO:0065008,GO:0070008,GO:0070011,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:0097159,GO:0140096,GO:1901135,GO:1901137,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901681 3.4.16.4 ko:K07258 ko00550,ko01100,map00550,map01100 - - - ko00000,ko00001,ko01000,ko01002,ko01011 - - iEC55989_1330.EC55989_2269,iSFV_1184.SFV_0694,iSbBS512_1146.SbBS512_E2506 PBP5_C,Peptidase_S11 k59_717477_1 768671.ThimaDRAFT_0197 1.18e-34 136.0 COG0834@1|root,COG4585@1|root,COG0834@2|Bacteria,COG4585@2|Bacteria,1N315@1224|Proteobacteria,1T3XJ@1236|Gammaproteobacteria 1236|Gammaproteobacteria ET Bacterial extracellular solute-binding proteins, family 3 - - - - - - - - - - - - SBP_bac_3 k59_149597_1 1122201.AUAZ01000002_gene1052 1.01e-132 396.0 COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,1RR14@1236|Gammaproteobacteria,463YE@72275|Alteromonadaceae 1236|Gammaproteobacteria I COG0365 Acyl-coenzyme A synthetases AMP-(fatty) acid ligases prpE - 6.2.1.17 ko:K01908 ko00640,ko01100,map00640,map01100 - R00926,R01354 RC00004,RC00043,RC00070,RC02816 ko00000,ko00001,ko01000,ko01004 - - - ACAS_N,AMP-binding,AMP-binding_C k59_717481_1 1267534.KB906756_gene311 1.02e-13 70.9 COG0126@1|root,COG0126@2|Bacteria,3Y2T7@57723|Acidobacteria,2JI0Z@204432|Acidobacteriia 204432|Acidobacteriia F Belongs to the phosphoglycerate kinase family pgk - 2.7.2.3 ko:K00927 ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01512 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000,ko04147 - - - PGK k59_717481_2 1123261.AXDW01000001_gene1231 1.05e-30 117.0 COG0149@1|root,COG0149@2|Bacteria,1MWK5@1224|Proteobacteria,1RM8I@1236|Gammaproteobacteria,1X3VV@135614|Xanthomonadales 135614|Xanthomonadales G Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) tpiA GO:0003674,GO:0003824,GO:0004807,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006066,GO:0006071,GO:0006081,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0018130,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019400,GO:0019405,GO:0019438,GO:0019439,GO:0019563,GO:0019637,GO:0019682,GO:0019693,GO:0019751,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044262,GO:0044270,GO:0044271,GO:0044275,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046164,GO:0046166,GO:0046174,GO:0046184,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1901615,GO:1901616 5.3.1.1 ko:K01803 ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003 R01015 RC00423 ko00000,ko00001,ko00002,ko01000,ko04147 - - - TIM k59_207116_1 247639.MGP2080_11993 1.66e-107 324.0 COG1228@1|root,COG1228@2|Bacteria,1MXXR@1224|Proteobacteria,1RRK7@1236|Gammaproteobacteria,1J7PK@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria Q COG1228 Imidazolonepropionase and related amidohydrolases - - - - - - - - - - - - Amidohydro_1,Amidohydro_3 k59_264332_1 4558.Sb01g006640.1 1.14e-39 139.0 COG1143@1|root,KOG3256@2759|Eukaryota,37KYT@33090|Viridiplantae,3GDJE@35493|Streptophyta,3KM57@4447|Liliopsida,3IEF3@38820|Poales 35493|Streptophyta C 4Fe-4S dicluster domain - GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0005746,GO:0005747,GO:0016020,GO:0019866,GO:0030964,GO:0031090,GO:0031966,GO:0031967,GO:0031975,GO:0032991,GO:0043167,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044425,GO:0044429,GO:0044444,GO:0044446,GO:0044455,GO:0044464,GO:0045271,GO:0046872,GO:0070469,GO:0098796,GO:0098798,GO:0098800,GO:0098803,GO:1902494,GO:1990204 1.6.5.3,1.6.99.3 ko:K03941 ko00190,ko01100,ko04714,ko04723,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map04714,map04723,map04932,map05010,map05012,map05016 M00143 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1.6 - - Fer4 k59_264332_2 555793.WSK_1061 1.31e-83 251.0 COG0839@1|root,COG0839@2|Bacteria,1MWJV@1224|Proteobacteria,2TRB2@28211|Alphaproteobacteria,2JZZS@204457|Sphingomonadales 204457|Sphingomonadales C Belongs to the complex I subunit 6 family nuoJ - 1.6.5.3 ko:K00339 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q3 k59_430385_1 436308.Nmar_0393 2.63e-07 53.5 COG1404@1|root,arCOG00702@2157|Archaea,41SX3@651137|Thaumarchaeota 651137|Thaumarchaeota O Belongs to the peptidase S8 family - - - ko:K14647 ko02024,map02024 - - - ko00000,ko00001,ko01000,ko01002,ko03110 - - - PA,Peptidase_S8 k59_430385_2 1229909.NSED_01890 9.76e-88 272.0 COG1866@1|root,arCOG06073@2157|Archaea,41SE5@651137|Thaumarchaeota 651137|Thaumarchaeota C Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA pckA - 4.1.1.49 ko:K01610 ko00010,ko00020,ko00620,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00710,map01100,map01110,map01120,map01130,map01200 M00003,M00170 R00341 RC00002,RC02741 ko00000,ko00001,ko00002,ko01000 - - - PEPCK_ATP k59_1566272_1 1415780.JPOG01000001_gene1954 5.09e-23 104.0 COG3103@1|root,COG3103@2|Bacteria,1MVX1@1224|Proteobacteria,1S3BH@1236|Gammaproteobacteria 1236|Gammaproteobacteria T N-Acetylmuramoyl-L-alanine amidase - - - - - - - - - - - - AMIN k59_717490_1 1452718.JBOY01000008_gene3472 1.34e-06 51.2 COG0810@1|root,COG0810@2|Bacteria,1MUMT@1224|Proteobacteria 1224|Proteobacteria M Periplasmic protein TonB links inner and outer membranes tonB3 - - ko:K03832 - - - - ko00000,ko02000 2.C.1.1 - - TonB_2,TonB_C k59_717490_2 745014.OMB55_00022010 4.97e-46 157.0 COG0189@1|root,COG0189@2|Bacteria,1MVUA@1224|Proteobacteria,1RMU0@1236|Gammaproteobacteria,1J4CV@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Belongs to the prokaryotic GSH synthase family gshB GO:0000287,GO:0003674,GO:0003824,GO:0004363,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006518,GO:0006575,GO:0006749,GO:0006750,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0019184,GO:0034641,GO:0042398,GO:0043043,GO:0043167,GO:0043169,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0051186,GO:0051188,GO:0071704,GO:1901564,GO:1901566,GO:1901576 6.3.2.3 ko:K01920 ko00270,ko00480,ko01100,map00270,map00480,map01100 M00118 R00497,R10994 RC00096,RC00141 ko00000,ko00001,ko00002,ko01000 - - iECED1_1282.ECED1_3410,iECP_1309.ECP_2941 GSH-S_ATP,GSH-S_N k59_1223712_1 331869.BAL199_19366 5.62e-77 249.0 COG0021@1|root,COG0021@2|Bacteria,1MUEY@1224|Proteobacteria,2TQUX@28211|Alphaproteobacteria,4BPMI@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria G Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate tkt - 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 - - - Transket_pyr,Transketolase_C,Transketolase_N k59_1566286_1 1382306.JNIM01000001_gene348 3.82e-112 343.0 COG0318@1|root,COG0318@2|Bacteria,2G5SX@200795|Chloroflexi 200795|Chloroflexi IQ AMP-binding enzyme C-terminal domain - - - ko:K00666 - - - - ko00000,ko01000,ko01004 - - - AMP-binding,AMP-binding_C k59_39613_1 228405.HNE_2994 1.16e-59 187.0 COG5485@1|root,COG5485@2|Bacteria,1RFES@1224|Proteobacteria,2U8B5@28211|Alphaproteobacteria 28211|Alphaproteobacteria S SnoaL-like polyketide cyclase - - - - - - - - - - - - SnoaL_2 k59_1783712_1 866536.Belba_2760 2.17e-35 137.0 COG4584@1|root,COG4584@2|Bacteria,4NEY6@976|Bacteroidetes,47MFD@768503|Cytophagia 976|Bacteroidetes L PFAM integrase - - - - - - - - - - - - HTH_23,rve k59_1333780_1 1000565.METUNv1_00214 5.82e-53 188.0 COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,2VJIV@28216|Betaproteobacteria,2KUK2@206389|Rhodocyclales 206389|Rhodocyclales F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides - - 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - ATP-cone,Ribonuc_red_lgC,Ribonuc_red_lgN k59_1276845_1 95619.PM1_0203195 9.98e-61 218.0 COG1629@1|root,COG4771@2|Bacteria,1MX42@1224|Proteobacteria,1RQ2K@1236|Gammaproteobacteria 1236|Gammaproteobacteria P receptor phuR - - ko:K16087,ko:K16089 - - - - ko00000,ko02000 1.B.14.1,1.B.14.10,1.B.14.2 - - Plug,TonB_dep_Rec k59_541140_1 269796.Rru_A3560 1.11e-31 127.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2TT8R@28211|Alphaproteobacteria,2JPD1@204441|Rhodospirillales 204441|Rhodospirillales T Putative diguanylate phosphodiesterase - - - - - - - - - - - - EAL,GGDEF,PAS,PAS_3,PAS_4,PAS_9 k59_604396_1 314285.KT71_08440 3.88e-103 317.0 COG1053@1|root,COG1053@2|Bacteria,1MU5M@1224|Proteobacteria,1RYVY@1236|Gammaproteobacteria,1J84E@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Fumarate reductase flavoprotein C-term - - 1.3.5.4 ko:K00244 ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020 M00009,M00011,M00150,M00173 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,Succ_DH_flav_C k59_1333782_1 436308.Nmar_1000 1.79e-55 190.0 arCOG11734@1|root,arCOG11734@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_1508783_1 317025.Tcr_0390 1.26e-10 62.0 COG0373@1|root,COG0373@2|Bacteria,1MU41@1224|Proteobacteria,1RNQ8@1236|Gammaproteobacteria,460DY@72273|Thiotrichales 72273|Thiotrichales H Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) hemA - 1.2.1.70 ko:K02492 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R04109 RC00055,RC00149 ko00000,ko00001,ko00002,ko01000 - - - GlutR_N,GlutR_dimer,Shikimate_DH k59_1055825_1 1454004.AW11_02876 1.19e-103 311.0 COG3344@1|root,COG3344@2|Bacteria,1MVI1@1224|Proteobacteria,2VMDU@28216|Betaproteobacteria 28216|Betaproteobacteria L RNA-directed DNA polymerase - - 2.7.7.49 ko:K00986 - - - - ko00000,ko01000 - - - GIIM,Intron_maturas2,RVT_1 k59_1223735_1 1249975.JQLP01000001_gene3060 1.78e-05 52.0 COG3291@1|root,COG3291@2|Bacteria,4NDZQ@976|Bacteroidetes,1HX5A@117743|Flavobacteriia,2P61H@244698|Gillisia 976|Bacteroidetes S C-terminal domain of CHU protein family - - - - - - - - - - - - CHU_C,HYR,IgGFc_binding,Lectin_leg-like,SprB k59_264393_1 555079.Toce_0821 6.7e-40 147.0 COG0457@1|root,COG3359@1|root,COG0457@2|Bacteria,COG3359@2|Bacteria,1TQQU@1239|Firmicutes,25JM1@186801|Clostridia,42HJP@68295|Thermoanaerobacterales 186801|Clostridia L RNase_H superfamily - - - ko:K07502 - - - - ko00000 - - - RNase_H_2 k59_1508786_1 990285.RGCCGE502_22105 2.45e-50 182.0 COG2114@1|root,COG4252@1|root,COG2114@2|Bacteria,COG4252@2|Bacteria,1MV1V@1224|Proteobacteria,2TRTY@28211|Alphaproteobacteria,4B8DM@82115|Rhizobiaceae 28211|Alphaproteobacteria T Adenylate cyaD - 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 - - - CHASE2,Guanylate_cyc k59_379244_1 1121374.KB891585_gene2291 2.03e-59 186.0 COG0229@1|root,COG0229@2|Bacteria,1RGWC@1224|Proteobacteria,1S5WI@1236|Gammaproteobacteria 1236|Gammaproteobacteria O Belongs to the MsrB Met sulfoxide reductase family msrB - 1.8.4.12 ko:K07305 - - - - ko00000,ko01000 - - - SelR k59_604415_2 300852.55771677 3.16e-12 67.4 COG0589@1|root,COG0589@2|Bacteria,1WJVG@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus T Universal stress protein - - - - - - - - - - - - Usp k59_1223755_1 1121931.AUHG01000011_gene2176 1.12e-30 125.0 COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,4NHS5@976|Bacteroidetes,1HZ0Y@117743|Flavobacteriia 976|Bacteroidetes EU peptidase - - - - - - - - - - - - PD40,Peptidase_S9 k59_379249_1 502025.Hoch_5653 2.44e-122 357.0 COG0708@1|root,COG0708@2|Bacteria,1MVII@1224|Proteobacteria,42NY7@68525|delta/epsilon subdivisions,2WIXK@28221|Deltaproteobacteria,2Z364@29|Myxococcales 28221|Deltaproteobacteria L Endonuclease/Exonuclease/phosphatase family - - 3.1.11.2 ko:K01142 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - Exo_endo_phos k59_486057_1 1207063.P24_02246 6.88e-38 139.0 COG0697@1|root,COG0697@2|Bacteria,1MZQM@1224|Proteobacteria,2TUPG@28211|Alphaproteobacteria,2JQS8@204441|Rhodospirillales 204441|Rhodospirillales EG EamA-like transporter family - - - - - - - - - - - - EamA k59_39639_1 666509.RCA23_c08300 3.93e-75 231.0 COG0411@1|root,COG0411@2|Bacteria,1MUFT@1224|Proteobacteria,2U22X@28211|Alphaproteobacteria 28211|Alphaproteobacteria E branched-chain amino acid - - - ko:K01995 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - ABC_tran,BCA_ABC_TP_C k59_775689_1 1112217.PPL19_12528 3.76e-30 110.0 COG4696@1|root,COG4696@2|Bacteria,1N92T@1224|Proteobacteria,1SP95@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Protein conserved in bacteria - - - - - - - - - - - - - k59_775689_2 479434.Sthe_3290 3.82e-31 118.0 COG3663@1|root,COG3663@2|Bacteria,2G9BC@200795|Chloroflexi 200795|Chloroflexi L Uracil DNA glycosylase superfamily - - 3.2.2.28 ko:K03649 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - UDG k59_1063251_1 5334.XP_003032316.1 5.98e-05 47.0 COG0642@1|root,KOG0519@2759|Eukaryota,38EIJ@33154|Opisthokonta,3NVY0@4751|Fungi,3UYEV@5204|Basidiomycota,224EP@155619|Agaricomycetes,3W5UT@5338|Agaricales 4751|Fungi T Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - - - - - - - - - - GAF,HATPase_c,HisKA,Response_reg k59_1063251_2 34506.g816 5.44e-66 227.0 COG0621@1|root,KOG2492@2759|Eukaryota,39W8Q@33154|Opisthokonta,3BFMT@33208|Metazoa,3DD6H@33213|Bilateria,40QX1@6231|Nematoda,1M7UH@119089|Chromadorea,4171R@6236|Rhabditida 33208|Metazoa T Uncharacterized protein family UPF0004 - - - - - - - - - - - - PhoH,Radical_SAM,TRAM,UPF0004 k59_1681917_1 1122137.AQXF01000005_gene1131 3.86e-119 358.0 COG2234@1|root,COG2234@2|Bacteria,1MUZ7@1224|Proteobacteria,2TRSJ@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Peptidase, M28 - - - - - - - - - - - - PA,Peptidase_M28 k59_664339_1 396588.Tgr7_1754 5.11e-69 219.0 COG1472@1|root,COG1472@2|Bacteria,1MVAJ@1224|Proteobacteria,1RMQF@1236|Gammaproteobacteria,1WXR0@135613|Chromatiales 135613|Chromatiales G Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide-linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N-acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides nagZ - 3.2.1.52 ko:K01207 ko00520,ko00531,ko01100,ko01501,map00520,map00531,map01100,map01501 M00628 R00022,R05963,R07809,R07810,R10831 RC00049 ko00000,ko00001,ko00002,ko01000 - - - Glyco_hydro_3 k59_1001982_1 875328.JDM601_3521 7.53e-92 276.0 COG2175@1|root,COG2175@2|Bacteria,2I8RZ@201174|Actinobacteria,2363N@1762|Mycobacteriaceae 201174|Actinobacteria Q taurine catabolism dioxygenase - - - - - - - - - - - - TauD k59_1230816_1 1027273.GZ77_01815 2.96e-71 223.0 COG0692@1|root,COG0692@2|Bacteria,1MV80@1224|Proteobacteria,1RPDH@1236|Gammaproteobacteria,1XI06@135619|Oceanospirillales 135619|Oceanospirillales L Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine ung - 3.2.2.27 ko:K03648 ko03410,ko05340,map03410,map05340 - - - ko00000,ko00001,ko01000,ko03400 - - - UDG k59_549167_1 1137281.D778_00984 4.86e-98 293.0 COG1360@1|root,COG1360@2|Bacteria,4NF2Y@976|Bacteroidetes,1HY7B@117743|Flavobacteriia 976|Bacteroidetes N flagellar motor protein - - - ko:K02557 ko02030,ko02040,map02030,map02040 - - - ko00000,ko00001,ko02000,ko02035 1.A.30.1 - - OmpA k59_946188_2 670307.HYPDE_22888 1.49e-29 115.0 COG3023@1|root,COG3023@2|Bacteria,1RDHU@1224|Proteobacteria,2TSW3@28211|Alphaproteobacteria,3N7HW@45401|Hyphomicrobiaceae 28211|Alphaproteobacteria V N-acetylmuramyl-L-alanine amidase, negative regulator of AmpC, AmpD amiD GO:0000270,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0006022,GO:0006026,GO:0006027,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008745,GO:0009056,GO:0009057,GO:0009253,GO:0009254,GO:0009392,GO:0016020,GO:0016787,GO:0016810,GO:0016811,GO:0019867,GO:0030203,GO:0043167,GO:0043169,GO:0043170,GO:0046872,GO:0046914,GO:0061783,GO:0071704,GO:1901135,GO:1901136,GO:1901564,GO:1901565,GO:1901575 2.5.1.3,3.5.1.28 ko:K00788,ko:K01447,ko:K03806 ko00730,ko01100,map00730,map01100 M00127 R03223,R04112,R10712 RC00064,RC00141,RC00224,RC03255,RC03397 ko00000,ko00001,ko00002,ko01000,ko01011 - - - Amidase_2,PG_binding_1 k59_157235_1 360910.BAV0846 3.78e-44 159.0 COG2027@1|root,COG2027@2|Bacteria,1MW40@1224|Proteobacteria,2VH20@28216|Betaproteobacteria,3T1FM@506|Alcaligenaceae 28216|Betaproteobacteria M D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) dacB - 3.4.16.4 ko:K07259 ko00550,map00550 - - - ko00000,ko00001,ko01000,ko01002,ko01011 - - - Peptidase_S13 k59_549175_1 1122137.AQXF01000002_gene242 2.09e-60 198.0 COG2951@1|root,COG2951@2|Bacteria,1MUZ3@1224|Proteobacteria,2TRP0@28211|Alphaproteobacteria 28211|Alphaproteobacteria M Lytic murein transglycosylase mltB - - ko:K08305 - - - - ko00000,ko01000,ko01011 - GH103 - SLT_2 k59_947430_1 1131266.ARWQ01000009_gene951 9.66e-171 481.0 COG0535@1|root,arCOG00938@2157|Archaea,41SXS@651137|Thaumarchaeota 651137|Thaumarchaeota S 4Fe-4S single cluster domain - - - - - - - - - - - - Fer4_12,Radical_SAM k59_947436_1 1122137.AQXF01000005_gene1075 1.01e-84 256.0 COG2853@1|root,COG2853@2|Bacteria,1MVX0@1224|Proteobacteria,2U7CZ@28211|Alphaproteobacteria 28211|Alphaproteobacteria M (Lipo)protein - - - ko:K04754 - - - - ko00000 - - - MlaA k59_613262_1 1384484.AEQU_2191 4.77e-21 96.7 COG0631@1|root,COG0631@2|Bacteria,2GJ3M@201174|Actinobacteria,4CUGE@84998|Coriobacteriia 84998|Coriobacteriia T phosphatase 2C - - 3.1.3.16 ko:K20074 - - - - ko00000,ko01000,ko01009 - - - BofC_C,PP2C,PP2C_2 k59_215565_1 290512.Paes_2104 3.23e-28 111.0 COG3344@1|root,COG3344@2|Bacteria,1FEPS@1090|Chlorobi 1090|Chlorobi L PFAM RNA-directed DNA polymerase (Reverse transcriptase) - - 2.7.7.49 ko:K00986 - - - - ko00000,ko01000 - - - GIIM,RVT_1 k59_47933_1 1122604.JONR01000018_gene1065 1.73e-06 49.3 29W19@1|root,30HJP@2|Bacteria,1R60N@1224|Proteobacteria,1S21W@1236|Gammaproteobacteria,1X6BC@135614|Xanthomonadales 135614|Xanthomonadales - - - - - - - - - - - - - - - k59_1286319_1 1218352.B597_021950 9.9e-53 178.0 COG0541@1|root,COG0541@2|Bacteria,1MVIA@1224|Proteobacteria,1RMU9@1236|Gammaproteobacteria,1Z0BS@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components ffh GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006605,GO:0006612,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0032991,GO:0033036,GO:0034613,GO:0035639,GO:0036094,GO:0042886,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0045184,GO:0046907,GO:0048500,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0070727,GO:0071702,GO:0071705,GO:0072657,GO:0090150,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1990904 3.6.5.4 ko:K03106 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko01000,ko02044 3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9 - - SRP54,SRP54_N,SRP_SPB k59_273588_1 864051.BurJ1DRAFT_0192 1.07e-08 55.8 COG1704@1|root,COG1704@2|Bacteria,1MVH0@1224|Proteobacteria,2VHT5@28216|Betaproteobacteria,1KK0R@119065|unclassified Burkholderiales 28216|Betaproteobacteria S LemA family lemA - - ko:K03744 - - - - ko00000 - - - LemA k59_331260_1 1449335.JQLG01000004_gene310 3.69e-41 148.0 COG2309@1|root,COG2309@2|Bacteria,1TP65@1239|Firmicutes,4H9W8@91061|Bacilli,27FI0@186828|Carnobacteriaceae 91061|Bacilli E Thermophilic metalloprotease (M29) pepS - - ko:K19689 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M29 k59_776793_1 1088721.NSU_1563 6.34e-42 143.0 COG3577@1|root,COG3577@2|Bacteria,1N2PE@1224|Proteobacteria,2VG8N@28211|Alphaproteobacteria,2KE22@204457|Sphingomonadales 204457|Sphingomonadales S gag-polyprotein putative aspartyl protease - - - ko:K06985 ko04112,map04112 - - - ko00000,ko00001 - - - gag-asp_proteas k59_494636_2 1117314.PCIT_04203 1.46e-30 117.0 COG0535@1|root,COG0535@2|Bacteria,1PEN5@1224|Proteobacteria,1SDT2@1236|Gammaproteobacteria,2Q3ED@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria C Iron-sulfur cluster-binding domain - - - - - - - - - - - - Radical_SAM,SPASM k59_1405113_1 1286093.C266_14707 2.45e-39 142.0 2C171@1|root,2Z7ZR@2|Bacteria,1R8AZ@1224|Proteobacteria,2WIGH@28216|Betaproteobacteria,1KBEB@119060|Burkholderiaceae 28216|Betaproteobacteria S SIR2-like domain - - - - - - - - - - - - SIR2_2 k59_1405113_2 377629.TERTU_1467 1.48e-23 99.4 COG0433@1|root,COG0433@2|Bacteria,1MUSH@1224|Proteobacteria,1RRBD@1236|Gammaproteobacteria 1236|Gammaproteobacteria S AAA-like domain - - - ko:K06915 - - - - ko00000 - - - DUF87 k59_388186_1 85643.Tmz1t_0188 3.52e-53 185.0 COG3243@1|root,COG3243@2|Bacteria,1MU68@1224|Proteobacteria,2VKMW@28216|Betaproteobacteria,2KV2G@206389|Rhodocyclales 206389|Rhodocyclales I Poly-beta-hydroxybutyrate - - - ko:K03821 ko00650,map00650 - R04254 RC00004 ko00000,ko00001,ko01000 - - - PhaC_N k59_1456077_1 436308.Nmar_1608 4.1e-104 312.0 COG1012@1|root,arCOG01252@2157|Archaea,41T0F@651137|Thaumarchaeota 651137|Thaumarchaeota C PFAM Aldehyde dehydrogenase - - 1.2.1.16,1.2.1.20,1.2.1.79 ko:K00135,ko:K18601 ko00250,ko00310,ko00350,ko00650,ko00760,ko01100,ko01120,map00250,map00310,map00350,map00650,map00760,map01100,map01120 M00027 R00713,R00714,R02401 RC00080 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_331274_1 436308.Nmar_0517 3.3e-136 391.0 COG1405@1|root,arCOG01981@2157|Archaea,41S8Y@651137|Thaumarchaeota 651137|Thaumarchaeota K factor TFIIB - - - ko:K03124 ko03022,ko05169,ko05203,map03022,map05169,map05203 - - - ko00000,ko00001,ko03021 - - - TFIIB,TF_Zn_Ribbon k59_1792554_1 398580.Dshi_0315 6.33e-05 46.2 COG0564@1|root,COG0564@2|Bacteria,1MVDX@1224|Proteobacteria,2TTQC@28211|Alphaproteobacteria 28211|Alphaproteobacteria J Responsible for synthesis of pseudouridine from uracil rluC GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360 5.4.99.24 ko:K06179 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2,S4 k59_103961_1 491952.Mar181_2591 5.7e-38 131.0 COG0521@1|root,COG0521@2|Bacteria,1R9W2@1224|Proteobacteria,1S21E@1236|Gammaproteobacteria,1XJ5T@135619|Oceanospirillales 135619|Oceanospirillales H May be involved in the biosynthesis of molybdopterin moaB - 2.7.7.75 ko:K03638 ko00790,ko01100,map00790,map01100 - R09726 RC00002 ko00000,ko00001,ko01000 - - - MoCF_biosynth k59_103961_2 1122197.ATWI01000010_gene1151 1.1e-08 58.2 COG0303@1|root,COG0303@2|Bacteria,1MVD5@1224|Proteobacteria,1RMQU@1236|Gammaproteobacteria,4662Y@72275|Alteromonadaceae 1236|Gammaproteobacteria H COG0303 Molybdopterin biosynthesis enzyme moeA - 2.10.1.1 ko:K03750 ko00790,ko01100,map00790,map01100 - R09735 RC03462 ko00000,ko00001,ko01000 - - - MoCF_biosynth,MoeA_C,MoeA_N k59_1456085_1 880073.Calab_0391 9.23e-75 240.0 COG0119@1|root,COG0119@2|Bacteria,2NNVW@2323|unclassified Bacteria 2|Bacteria E Belongs to the alpha-IPM synthase homocitrate synthase family cimA - 2.3.3.13 ko:K01649 ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230 M00432 R01213 RC00004,RC00470,RC02754 br01601,ko00000,ko00001,ko00002,ko01000 - - - HMGL-like,LeuA_dimer k59_776827_1 710687.KI912270_gene73 4.7e-43 150.0 2EX42@1|root,33QF2@2|Bacteria,2I9M3@201174|Actinobacteria,235US@1762|Mycobacteriaceae 201174|Actinobacteria - - - - - - - - - - - - - - - k59_494653_1 224911.27356517 7.85e-13 71.6 COG0405@1|root,COG0405@2|Bacteria,1Q089@1224|Proteobacteria,2U8PM@28211|Alphaproteobacteria,3K32F@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria E Gamma-glutamyltranspeptidase - - 2.3.2.2,3.4.19.13 ko:K00681 ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100 - R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935 RC00064,RC00090,RC00096 ko00000,ko00001,ko01000,ko01002 - - - G_glu_transpept k59_836215_1 1229204.AMYY01000035_gene828 4.63e-37 140.0 COG4774@1|root,COG4774@2|Bacteria,1QVG7@1224|Proteobacteria,2TV9I@28211|Alphaproteobacteria 28211|Alphaproteobacteria P receptor - - - - - - - - - - - - Plug,TonB_dep_Rec k59_215591_1 1122137.AQXF01000002_gene72 1.45e-101 315.0 COG3808@1|root,COG3808@2|Bacteria,1MUQ3@1224|Proteobacteria,2TR9G@28211|Alphaproteobacteria 28211|Alphaproteobacteria C Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force hppA - 3.6.1.1 ko:K15987 ko00190,map00190 - - - ko00000,ko00001,ko01000 3.A.10.1 - - H_PPase k59_1627781_1 796942.HMPREF9623_00987 1.96e-32 126.0 COG0216@1|root,COG0216@2|Bacteria,1TQ7V@1239|Firmicutes,248CN@186801|Clostridia 186801|Clostridia J Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA prfA - - ko:K02835 - - - - ko00000,ko03012 - - - PCRF,RF-1 k59_1683131_1 616991.JPOO01000001_gene2984 5.57e-100 294.0 COG2940@1|root,COG2940@2|Bacteria,4NM5I@976|Bacteroidetes,1I1ME@117743|Flavobacteriia,23HVJ@178469|Arenibacter 976|Bacteroidetes S SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain - - - - - - - - - - - - SET k59_439204_2 1121878.AUGL01000001_gene166 1.26e-49 174.0 COG0122@1|root,COG2169@1|root,COG0122@2|Bacteria,COG2169@2|Bacteria,1QTXM@1224|Proteobacteria,1RNQB@1236|Gammaproteobacteria 1236|Gammaproteobacteria K COG2169 Adenosine deaminase ada - 3.2.2.21 ko:K01247,ko:K13529 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03000,ko03400 - - - Ada_Zn_binding,AlkA_N,HTH_18,HhH-GPD k59_1792579_1 1415778.JQMM01000001_gene1975 1.37e-137 408.0 COG0441@1|root,COG0441@2|Bacteria,1MUP2@1224|Proteobacteria,1RMYE@1236|Gammaproteobacteria,1J4XI@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) thrS GO:0003674,GO:0003824,GO:0004812,GO:0004829,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006435,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.3 ko:K01868 ko00970,map00970 M00359,M00360 R03663 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,TGS,tRNA-synt_2b,tRNA_SAD k59_1792586_1 1114964.L485_16810 2.63e-22 93.2 COG1414@1|root,COG1414@2|Bacteria,1NVYA@1224|Proteobacteria,2US7Y@28211|Alphaproteobacteria,2KAFJ@204457|Sphingomonadales 204457|Sphingomonadales K helix_turn_helix isocitrate lyase regulation - - - - - - - - - - - - HTH_IclR k59_1003153_1 870187.Thini_3392 3.22e-44 160.0 COG0769@1|root,COG0769@2|Bacteria,1MU6P@1224|Proteobacteria,1RMD6@1236|Gammaproteobacteria,45ZR1@72273|Thiotrichales 72273|Thiotrichales M acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan murE - 6.3.2.13 ko:K01928 ko00300,ko00550,map00300,map00550 - R02788 RC00064,RC00090 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_1286378_1 983920.Y88_0010 5.8e-34 129.0 COG2710@1|root,COG2710@2|Bacteria,1MWSX@1224|Proteobacteria,2TTNK@28211|Alphaproteobacteria,2K9A4@204457|Sphingomonadales 204457|Sphingomonadales H Belongs to the NifD NifK NifE NifN family - - - ko:K02592 - - - - ko00000 - - - Oxidored_nitro k59_1286378_2 983920.Y88_0009 7.5e-34 119.0 COG1433@1|root,COG1433@2|Bacteria,1RD9P@1224|Proteobacteria,2U9AX@28211|Alphaproteobacteria,2KBAA@204457|Sphingomonadales 204457|Sphingomonadales S PFAM Dinitrogenase iron-molybdenum cofactor biosynthesis protein - - - ko:K02596 - - - - ko00000 - - - Nitro_FeMo-Co k59_1064449_1 224911.27353268 0.000266 51.2 COG0582@1|root,COG0582@2|Bacteria,1MWBN@1224|Proteobacteria,2TUNW@28211|Alphaproteobacteria,3JW40@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria L Phage integrase family - - - - - - - - - - - - Phage_integrase k59_613346_2 1229909.NSED_09150 4.02e-15 74.7 COG1829@1|root,arCOG04263@2157|Archaea,41T1V@651137|Thaumarchaeota 651137|Thaumarchaeota S kinase, sugar kinase superfamily - - 2.7.1.169 ko:K06982 ko00770,ko01100,map00770,map01100 - R09378 RC00002,RC00017 ko00000,ko00001,ko01000 - - - GHMP_kinases_N k59_494686_1 1306947.ARQD01000001_gene675 2.46e-05 46.2 COG0728@1|root,COG0728@2|Bacteria,2NNX8@2323|unclassified Bacteria 2|Bacteria U Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane murJ GO:0000270,GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0006810,GO:0006869,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0010876,GO:0015647,GO:0015648,GO:0015835,GO:0015836,GO:0016020,GO:0016021,GO:0016043,GO:0022857,GO:0022884,GO:0030203,GO:0031224,GO:0031226,GO:0033036,GO:0034204,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0061024,GO:0065007,GO:0065008,GO:0070589,GO:0071554,GO:0071702,GO:0071704,GO:0071705,GO:0071840,GO:0071944,GO:0097035,GO:1901135,GO:1901137,GO:1901264,GO:1901505,GO:1901564,GO:1901566,GO:1901576 - ko:K03980 - - - - ko00000,ko01011,ko02000 2.A.66.4 - - MVIN k59_1792595_1 1123322.KB904668_gene3717 4.75e-38 144.0 COG0305@1|root,COG0467@1|root,COG0305@2|Bacteria,COG0467@2|Bacteria,2IAGX@201174|Actinobacteria 201174|Actinobacteria LT AAA domain - - 3.6.4.12 ko:K02314 ko03030,ko04112,map03030,map04112 - - - ko00000,ko00001,ko01000,ko03032 - - - AAA_25,DnaB k59_47982_1 1005395.CSV86_19358 1.94e-46 164.0 COG0845@1|root,COG0845@2|Bacteria,1N97Q@1224|Proteobacteria,1RXZP@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Multidrug transporter - - - - - - - - - - - - Biotin_lipoyl_2,GAF,HlyD_3,HlyD_D23 k59_47982_2 1301098.PKB_3106 6.74e-13 72.0 COG0845@1|root,COG1994@1|root,COG0845@2|Bacteria,COG1994@2|Bacteria,1MW9I@1224|Proteobacteria,1RRTY@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Peptidase M50 - - - ko:K16922 - - - - ko00000,ko01002 - - - Biotin_lipoyl_2,HlyD_3,HlyD_D23 k59_1575064_1 1122137.AQXF01000001_gene2872 5.72e-83 255.0 COG2021@1|root,COG2021@2|Bacteria,1MVJV@1224|Proteobacteria,2TQYA@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine metXA GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004414,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008374,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009086,GO:0009092,GO:0009987,GO:0016053,GO:0016407,GO:0016413,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.3.1.31 ko:K00641 ko00270,ko01100,ko01130,map00270,map01100,map01130 - R01776 RC00004,RC00041 ko00000,ko00001,ko01000 - - - Abhydrolase_1 k59_1575064_2 1122137.AQXF01000001_gene2871 4.61e-92 279.0 COG0079@1|root,COG0079@2|Bacteria,1MW7I@1224|Proteobacteria,2TQPN@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily hisC - 2.6.1.9 ko:K00817 ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230 M00026 R00694,R00734,R03243 RC00006,RC00888 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 k59_47989_1 234831.PSM_B0311 2.74e-27 107.0 COG1403@1|root,COG1403@2|Bacteria,1N9PJ@1224|Proteobacteria,1SD8R@1236|Gammaproteobacteria 1236|Gammaproteobacteria L HNH nucleases - - - - - - - - - - - - HNH k59_48000_1 411479.BACUNI_03805 1.56e-18 85.5 COG3250@1|root,COG3250@2|Bacteria,4NKZX@976|Bacteroidetes,2FNTC@200643|Bacteroidia,4APHM@815|Bacteroidaceae 976|Bacteroidetes G Beta galactosidase small chain - - 3.2.1.23 ko:K01190 ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100 - R01105,R01678,R03355,R04783,R06114 RC00049,RC00452 ko00000,ko00001,ko01000 - - - Bgal_small_N,DUF4981,Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N,Laminin_G_3 k59_1003169_1 1121943.KB900003_gene2829 4.23e-56 192.0 COG0728@1|root,COG0728@2|Bacteria,1MUH0@1224|Proteobacteria,1RMXX@1236|Gammaproteobacteria,1XH8T@135619|Oceanospirillales 135619|Oceanospirillales S Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane murJ - - ko:K03980 - - - - ko00000,ko01011,ko02000 2.A.66.4 - - MVIN k59_1286396_1 556268.OFAG_00266 1.06e-22 93.2 COG0663@1|root,COG0663@2|Bacteria,1RD76@1224|Proteobacteria,2VR65@28216|Betaproteobacteria,4740H@75682|Oxalobacteraceae 28216|Betaproteobacteria S Bacterial transferase hexapeptide (six repeats) yrdA - - - - - - - - - - - Hexapep k59_1286396_2 1265502.KB905951_gene821 1.24e-22 97.1 COG0665@1|root,COG0665@2|Bacteria,1MVIZ@1224|Proteobacteria,2VH1D@28216|Betaproteobacteria,4A9ZE@80864|Comamonadaceae 28216|Betaproteobacteria C PFAM FAD dependent oxidoreductase dadA4 - 1.4.5.1 ko:K00285 ko00360,map00360 - R01374,R09493 RC00006,RC00025 ko00000,ko00001,ko01000 - - - DAO,FAD_binding_2 k59_439220_1 83406.HDN1F_16240 1.52e-74 239.0 COG0464@1|root,COG0464@2|Bacteria,1MW4T@1224|Proteobacteria,1RPUI@1236|Gammaproteobacteria,1J50R@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O ATPase family associated with various cellular activities (AAA) - - - - - - - - - - - - AAA k59_947564_1 314225.ELI_04655 1.39e-96 299.0 COG4147@1|root,COG4147@2|Bacteria,1MVJ8@1224|Proteobacteria,2TTA4@28211|Alphaproteobacteria,2K3ET@204457|Sphingomonadales 204457|Sphingomonadales S Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family actP - - ko:K14393 - - - - ko00000,ko02000 2.A.21.7 - - SSF k59_48015_1 1210884.HG799466_gene12589 0.0002 45.4 COG1677@1|root,COG1677@2|Bacteria,2J1P2@203682|Planctomycetes 203682|Planctomycetes N Flagellar hook-basal body complex protein FliE fliE - - ko:K02408 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - FliE k59_1129564_1 1123023.JIAI01000015_gene3181 1.91e-08 60.5 COG0642@1|root,COG2205@2|Bacteria,2GNUQ@201174|Actinobacteria,4DZ34@85010|Pseudonocardiales 201174|Actinobacteria T Histidine kinase - - - - - - - - - - - - HAMP,HATPase_c,HisKA k59_1298744_1 290397.Adeh_1619 7.94e-83 261.0 COG0044@1|root,COG0044@2|Bacteria,1MVXY@1224|Proteobacteria,42MJ9@68525|delta/epsilon subdivisions,2WJH8@28221|Deltaproteobacteria,2YU2Z@29|Myxococcales 28221|Deltaproteobacteria F Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily pyrC GO:0003674,GO:0003824,GO:0004038,GO:0004151,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006144,GO:0006145,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016787,GO:0016810,GO:0016812,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046113,GO:0046390,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576 3.5.2.3 ko:K01465 ko00240,ko01100,map00240,map01100 M00051 R01993 RC00632 ko00000,ko00001,ko00002,ko01000 - - - Amidohydro_1 k59_788948_1 221360.RS9917_13315 2.24e-50 175.0 COG3666@1|root,COG3666@2|Bacteria,1GEUC@1117|Cyanobacteria 1117|Cyanobacteria L PFAM Transposase DDE domain - - - - - - - - - - - - DDE_Tnp_1_6,DUF772 k59_506746_1 1219375.CM002139_gene3946 2.42e-80 263.0 COG4773@1|root,COG4773@2|Bacteria,1QTT0@1224|Proteobacteria,1RNBT@1236|Gammaproteobacteria,1X5NT@135614|Xanthomonadales 135614|Xanthomonadales P TonB dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_1129579_1 1294143.H681_21220 6.5e-32 124.0 COG0439@1|root,COG4799@1|root,COG0439@2|Bacteria,COG4799@2|Bacteria,1MU4H@1224|Proteobacteria,1RQ9Q@1236|Gammaproteobacteria 1236|Gammaproteobacteria I Biotin carboxylase pyc - - - - - - - - - - - Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2,Carboxyl_trans k59_562825_1 247634.GPB2148_688 3.81e-90 290.0 COG1391@1|root,COG1391@2|Bacteria,1MU4I@1224|Proteobacteria,1RP9N@1236|Gammaproteobacteria 1236|Gammaproteobacteria H Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell glnE GO:0000166,GO:0000287,GO:0000820,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006521,GO:0006541,GO:0006542,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0008882,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0010565,GO:0016053,GO:0016740,GO:0016772,GO:0016779,GO:0017076,GO:0019222,GO:0019752,GO:0030554,GO:0031323,GO:0032553,GO:0032555,GO:0032559,GO:0033238,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046872,GO:0050789,GO:0050794,GO:0051171,GO:0062012,GO:0065007,GO:0070566,GO:0071704,GO:0080090,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.7.42,2.7.7.89 ko:K00982 - - - - ko00000,ko01000 - - - GlnD_UR_UTase,GlnE k59_1129581_1 876269.ARWA01000001_gene3463 1.03e-28 110.0 28I9W@1|root,2Z8CH@2|Bacteria,1QCN6@1224|Proteobacteria,2U1GU@28211|Alphaproteobacteria,3NAQG@45404|Beijerinckiaceae 28211|Alphaproteobacteria S SIR2-like domain - - - - - - - - - - - - SIR2_2 k59_1129581_2 1038858.AXBA01000034_gene4887 1.56e-26 101.0 2E0VA@1|root,32WCJ@2|Bacteria,1RI6W@1224|Proteobacteria,2U91Z@28211|Alphaproteobacteria,3F1RK@335928|Xanthobacteraceae 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_1129581_3 857087.Metme_1919 1.47e-12 72.4 COG0354@1|root,COG0354@2|Bacteria,1N852@1224|Proteobacteria,1RPWB@1236|Gammaproteobacteria,1XEWJ@135618|Methylococcales 135618|Methylococcales S Belongs to the GcvT family - - - ko:K06980 - - - - ko00000,ko03016 - - - GCV_T k59_1015076_1 313596.RB2501_02915 1.1e-42 145.0 COG0218@1|root,COG0218@2|Bacteria,4NEA9@976|Bacteroidetes,1HXAB@117743|Flavobacteriia 976|Bacteroidetes D Necessary for normal cell division and for the maintenance of normal septation engB GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - ko:K03978 - - - - ko00000,ko03036 - - - MMR_HSR1 k59_1015076_2 143224.JQMD01000002_gene2077 8.84e-09 57.4 COG1482@1|root,COG1482@2|Bacteria,4NF9A@976|Bacteroidetes,1HXBP@117743|Flavobacteriia 976|Bacteroidetes G isomerase manA - 5.3.1.8 ko:K01809 ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130 M00114 R01819 RC00376 ko00000,ko00001,ko00002,ko01000 - - - PMI_typeI k59_562831_1 1229909.NSED_03575 1.1e-99 297.0 COG2519@1|root,arCOG00978@2157|Archaea,41SEF@651137|Thaumarchaeota 651137|Thaumarchaeota Q tRNA methyltransferase complex GCD14 subunit - - 2.1.1.219,2.1.1.220 ko:K07442 - - - - ko00000,ko01000,ko03016 - - - GCD14 k59_1129600_1 247634.GPB2148_1866 3.3e-34 129.0 COG0583@1|root,COG0583@2|Bacteria,1RI6D@1224|Proteobacteria,1S7GN@1236|Gammaproteobacteria,1J7TK@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria K Transcriptional regulator, LysR family - - - - - - - - - - - - HTH_1,LysR_substrate k59_677638_1 1550073.JROH01000008_gene1731 1.1e-28 118.0 COG0495@1|root,COG0495@2|Bacteria,1MV47@1224|Proteobacteria,2TQPK@28211|Alphaproteobacteria,2K0Q0@204457|Sphingomonadales 204457|Sphingomonadales J Belongs to the class-I aminoacyl-tRNA synthetase family leuS - 6.1.1.4 ko:K01869 ko00970,map00970 M00359,M00360 R03657 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - Anticodon_1,tRNA-synt_1,tRNA-synt_1_2 k59_1298783_1 690850.Desaf_1279 6.71e-26 110.0 COG0642@1|root,COG5002@1|root,COG2205@2|Bacteria,COG5002@2|Bacteria,1NRP8@1224|Proteobacteria,42M0Y@68525|delta/epsilon subdivisions,2WIR4@28221|Deltaproteobacteria,2M7T3@213115|Desulfovibrionales 28221|Deltaproteobacteria T histidine kinase A domain protein - - - - - - - - - - - - GAF_2,HATPase_c,HisKA,PAS,PAS_4,PAS_9,Response_reg k59_1298783_2 317655.Sala_0049 1.81e-28 122.0 COG0419@1|root,COG4717@1|root,COG0419@2|Bacteria,COG4717@2|Bacteria,1MVAW@1224|Proteobacteria,2TTMD@28211|Alphaproteobacteria,2K46E@204457|Sphingomonadales 204457|Sphingomonadales L AAA domain - - - - - - - - - - - - AAA_27 k59_1129611_1 1415778.JQMM01000001_gene640 1.52e-23 98.2 COG5008@1|root,COG5008@2|Bacteria,1QTTX@1224|Proteobacteria,1RN0B@1236|Gammaproteobacteria,1J564@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria NU COG5008 Tfp pilus assembly protein, ATPase PilU pilU - - ko:K02670 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE k59_1129611_2 95619.PM1_0226580 3.82e-43 146.0 COG0816@1|root,COG0816@2|Bacteria,1RDHZ@1224|Proteobacteria,1S96Q@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA yqgF GO:0000966,GO:0000967,GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008296,GO:0008408,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0022613,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0140097,GO:1901360 - ko:K07447 - - - - ko00000,ko01000 - - - RuvX k59_506796_1 558884.JRGM01000145_gene2036 4.16e-72 229.0 COG2148@1|root,COG2148@2|Bacteria,1MV6W@1224|Proteobacteria,1RMMN@1236|Gammaproteobacteria,1Y5VG@135624|Aeromonadales 135624|Aeromonadales M Bacterial sugar transferase - GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009243,GO:0009987,GO:0016051,GO:0016740,GO:0016772,GO:0016780,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0046402,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 2.7.8.40,2.7.8.6 ko:K00996,ko:K21303 - - - - ko00000,ko01000,ko01003,ko01005 - - - Bac_transf,CoA_binding_3 k59_562870_2 382464.ABSI01000012_gene2201 1.84e-09 62.8 COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria 2|Bacteria S cAMP biosynthetic process - - - - - - - - - - - - BTAD,TPR_11,TPR_16,TPR_7,TPR_8,Trans_reg_C k59_789018_2 1278309.KB907109_gene3283 3.41e-13 71.2 COG0038@1|root,COG0038@2|Bacteria,1MV4K@1224|Proteobacteria,1RQJW@1236|Gammaproteobacteria,1XHEE@135619|Oceanospirillales 135619|Oceanospirillales P Chloride channel - - - - - - - - - - - - CBS,Voltage_CLC k59_562898_1 566466.NOR53_1433 4.13e-83 269.0 COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MUT8@1224|Proteobacteria,1RN6R@1236|Gammaproteobacteria,1J5MR@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Pyruvate phosphate dikinase ppdK - 2.7.3.9,2.7.9.1,2.7.9.2 ko:K01006,ko:K01007,ko:K08483 ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,ko02060,map00620,map00680,map00710,map00720,map01100,map01120,map01200,map02060 M00169,M00171,M00172,M00173,M00374 R00199,R00206 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000,ko02000 8.A.7 - - PEP-utilizers,PEP-utilizers_C,PPDK_N k59_1354710_1 1437824.BN940_12546 0.000297 44.3 COG3572@1|root,COG3572@2|Bacteria,1N0R0@1224|Proteobacteria,2VUCP@28216|Betaproteobacteria,3T7KV@506|Alcaligenaceae 28216|Betaproteobacteria H Chalcone isomerase-like - - - - - - - - - - - - Chalcone_3 k59_1354710_2 1000565.METUNv1_00295 2e-56 187.0 COG2230@1|root,COG2230@2|Bacteria,1MX3U@1224|Proteobacteria,2VJ00@28216|Betaproteobacteria,2KVAC@206389|Rhodocyclales 206389|Rhodocyclales M Cyclopropane fatty acid synthase cfaA - 2.1.1.79 ko:K00574 - - - - ko00000,ko01000 - - - CMAS k59_451507_1 1144307.PMI04_04587 5.34e-68 232.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2TQT0@28211|Alphaproteobacteria,2K02H@204457|Sphingomonadales 204457|Sphingomonadales V Efflux pump membrane transporter - - - ko:K18138 ko01501,ko01503,map01501,map01503 M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000 2.A.6.2 - - ACR_tran k59_1298842_1 178901.AmDm5_2874 2.7e-99 305.0 COG3119@1|root,COG3119@2|Bacteria,1MV0B@1224|Proteobacteria,2TRI6@28211|Alphaproteobacteria 28211|Alphaproteobacteria P COG3119 Arylsulfatase A and related enzymes - - 3.1.6.6 ko:K01133 - - - - ko00000,ko01000 - - - DUF4976,HemolysinCabind,Sulfatase k59_506882_1 1380390.JIAT01000009_gene1076 5.89e-48 166.0 COG1893@1|root,COG1893@2|Bacteria,2GP6K@201174|Actinobacteria,4CTXT@84995|Rubrobacteria 84995|Rubrobacteria H Ketopantoate reductase PanE/ApbA C terminal - - 1.1.1.169 ko:K00077 ko00770,ko01100,ko01110,map00770,map01100,map01110 M00119 R02472 RC00726 ko00000,ko00001,ko00002,ko01000 - - - ApbA,ApbA_C k59_1354752_1 316407.85677029 3.3e-37 132.0 COG0609@1|root,COG0609@2|Bacteria,1MV9W@1224|Proteobacteria,1RR9X@1236|Gammaproteobacteria,3XRJS@561|Escherichia 1236|Gammaproteobacteria P Part of the binding-protein-dependent transport system for citrate-dependent Fe(3 ). Probably responsible for the translocation of the substrate across the membrane fecD GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0015603,GO:0015688,GO:0016020,GO:0022857,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:1901678 - ko:K02015 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko02000 3.A.1.14 - iB21_1397.B21_04117,iEC042_1314.EC042_4777,iEC55989_1330.EC55989_4961,iECABU_c1320.ECABU_c49000,iECBD_1354.ECBD_3750,iECB_1328.ECB_04154,iECD_1391.ECD_04154,iECED1_1282.ECED1_5153,iECNA114_1301.ECNA114_2547,iECO26_1355.ECO26_5456,iEcE24377_1341.EcE24377A_4865,iEcolC_1368.EcolC_0740,iUMNK88_1353.UMNK88_5227 FecCD k59_1354752_2 316407.85677030 5.28e-119 347.0 COG0609@1|root,COG0609@2|Bacteria,1R87A@1224|Proteobacteria,1RP2K@1236|Gammaproteobacteria,3XRJT@561|Escherichia 1236|Gammaproteobacteria P Part of the binding-protein-dependent transport system for citrate-dependent Fe(3 ). Probably responsible for the translocation of the substrate across the membrane fecC GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0015603,GO:0015688,GO:0016020,GO:0022857,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:1901678 - ko:K02015 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko02000 3.A.1.14 - iEC55989_1330.EC55989_4962,iECIAI39_1322.ECIAI39_4767,iEcE24377_1341.EcE24377A_4866 FecCD k59_1804975_1 983545.Glaag_3413 2.46e-56 182.0 COG0566@1|root,COG0566@2|Bacteria,1MWCM@1224|Proteobacteria,1RN2F@1236|Gammaproteobacteria,4640C@72275|Alteromonadaceae 1236|Gammaproteobacteria J Specifically methylates the ribose of guanosine 2251 in 23S rRNA rlmB GO:0000154,GO:0000451,GO:0000453,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070039,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.185 ko:K03218 - - - - ko00000,ko01000,ko03009 - - - SpoU_methylase,SpoU_sub_bind k59_1468672_1 1484460.JSWG01000009_gene317 1.95e-54 193.0 COG2373@1|root,COG3291@1|root,COG2373@2|Bacteria,COG3291@2|Bacteria,4NDZQ@976|Bacteroidetes,1HX5A@117743|Flavobacteriia 976|Bacteroidetes M C-terminal domain of CHU protein family - - - - - - - - - - - - CHU_C,Cleaved_Adhesin,MAM,fn3 k59_1129749_2 298386.PBPRA0440 7.04e-22 99.8 COG3267@1|root,COG3409@1|root,COG3267@2|Bacteria,COG3409@2|Bacteria,1MU3G@1224|Proteobacteria,1RMI0@1236|Gammaproteobacteria,1XSH3@135623|Vibrionales 135623|Vibrionales MU general secretion pathway protein exeA - - ko:K02450 - M00331 - - ko00000,ko00002,ko02044 9.B.42 - - AAA_22,PG_binding_1,T2SSB k59_1129751_1 314285.KT71_14689 6.09e-37 141.0 COG0729@1|root,COG0729@2|Bacteria,1MUKM@1224|Proteobacteria,1RNQ3@1236|Gammaproteobacteria,1J531@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M M COG4775 Outer membrane protein protective antigen OMA87 ytfM GO:0002790,GO:0005575,GO:0005623,GO:0006810,GO:0008104,GO:0008150,GO:0009279,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0019867,GO:0030312,GO:0030313,GO:0031224,GO:0031230,GO:0031975,GO:0032940,GO:0032991,GO:0033036,GO:0042886,GO:0044425,GO:0044462,GO:0044464,GO:0045184,GO:0045203,GO:0046903,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944,GO:0097347 - ko:K07278 - - - - ko00000,ko02000 1.B.33.2.4 - - Bac_surface_Ag,POTRA,POTRA_TamA_1 k59_959916_1 338963.Pcar_2889 1.07e-85 281.0 COG3299@1|root,COG3299@2|Bacteria,1MWKI@1224|Proteobacteria,42QGQ@68525|delta/epsilon subdivisions,2WIVM@28221|Deltaproteobacteria,43VNB@69541|Desulfuromonadales 28221|Deltaproteobacteria S Baseplate J-like protein - - - - - - - - - - - - Baseplate_J k59_506925_1 247634.GPB2148_2242 6.14e-31 125.0 COG1409@1|root,COG1409@2|Bacteria 2|Bacteria S acid phosphatase activity - - - - - - - - - - - - Metallophos,Pur_ac_phosph_N k59_506925_2 342610.Patl_3463 5.1e-14 70.1 COG2928@1|root,COG2928@2|Bacteria,1R79M@1224|Proteobacteria,1S6CC@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Protein of unknown function (DUF502) - - - - - - - - - - - - DUF502 k59_1298937_1 685035.ADAE01000018_gene497 8.95e-91 276.0 COG3535@1|root,COG3535@2|Bacteria,1NCBV@1224|Proteobacteria,2TU70@28211|Alphaproteobacteria,2K3WI@204457|Sphingomonadales 204457|Sphingomonadales S Protein of unknown function (DUF917) - - - ko:K09703 - - - - ko00000 - - - DUF917 k59_1298937_2 33188.XP_002585319.1 1.45e-05 47.4 COG0145@1|root,2QQBE@2759|Eukaryota,38D7D@33154|Opisthokonta,3NXTA@4751|Fungi,3QRFJ@4890|Ascomycota,20CYK@147545|Eurotiomycetes,3B2HF@33183|Onygenales 4751|Fungi EQ Protein of unknown function (DUF917) - - - - - - - - - - - - DUF917,Hydant_A_N,Hydantoinase_A k59_959943_1 1100720.ALKN01000028_gene2604 8.81e-65 210.0 COG0639@1|root,COG0639@2|Bacteria,1PXN4@1224|Proteobacteria 1224|Proteobacteria T COG0639 Diadenosine tetraphosphatase and related serine threonine protein phosphatases - - - - - - - - - - - - Metallophos_2 k59_451596_1 1280950.HJO_10534 5.39e-49 170.0 COG0277@1|root,COG0277@2|Bacteria,1NB6A@1224|Proteobacteria,2U3ZG@28211|Alphaproteobacteria,43ZF5@69657|Hyphomonadaceae 28211|Alphaproteobacteria C COG0277 FAD FMN-containing dehydrogenases xyoA - 1.1.3.41 ko:K00594 ko00040,ko00051,ko01100,map00040,map00051,map01100 - R07152,R11620 RC00108,RC00133 ko00000,ko00001,ko01000 - - - ALO,FAD_binding_4 k59_677771_1 702113.PP1Y_AT35241 3.41e-88 283.0 COG1674@1|root,COG1674@2|Bacteria,1MVPI@1224|Proteobacteria,2TR48@28211|Alphaproteobacteria,2K02P@204457|Sphingomonadales 204457|Sphingomonadales D DNA segregation ATPase FtsK SpoIIIE ftsK - - ko:K03466 - - - - ko00000,ko03036 3.A.12 - - FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma k59_1805012_1 553385.JEMF01000039_gene2923 1.18e-39 150.0 COG1570@1|root,COG1570@2|Bacteria,1MUA4@1224|Proteobacteria,1RNAZ@1236|Gammaproteobacteria,1XIJ4@135619|Oceanospirillales 135619|Oceanospirillales L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides xseA - 3.1.11.6 ko:K03601 ko03430,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - Exonuc_VII_L,tRNA_anti_2 k59_789154_1 861299.J421_1532 2.78e-59 203.0 COG0021@1|root,COG0021@2|Bacteria,1ZTA2@142182|Gemmatimonadetes 142182|Gemmatimonadetes G Transketolase, thiamine diphosphate binding domain - - 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 - - - Transket_pyr,Transketolase_C,Transketolase_N k59_677784_1 1144275.COCOR_03246 1.23e-129 393.0 COG1217@1|root,COG1217@2|Bacteria,1MV5Q@1224|Proteobacteria,42M3S@68525|delta/epsilon subdivisions,2WJVZ@28221|Deltaproteobacteria,2YU94@29|Myxococcales 28221|Deltaproteobacteria T GTP-binding protein typA - - ko:K06207 - - - - ko00000 - - - EFG_C,GTP_EFTU,GTP_EFTU_D2 k59_959985_1 1469557.JSWF01000028_gene3025 4.22e-49 168.0 COG0330@1|root,COG0330@2|Bacteria,4NFPK@976|Bacteroidetes,1HZJ2@117743|Flavobacteriia 976|Bacteroidetes O prohibitin homologues - - - - - - - - - - - - Band_7 k59_1298983_1 287.DR97_6182 9.06e-55 191.0 COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,1RNBK@1236|Gammaproteobacteria,1YJ97@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria IQ AMP-binding enzyme C-terminal domain - - 6.2.1.3 ko:K00666,ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding,AMP-binding_C k59_507000_1 314225.ELI_07095 3.92e-84 265.0 COG0516@1|root,COG0517@1|root,COG0516@2|Bacteria,COG0517@2|Bacteria,1MUJM@1224|Proteobacteria,2TQXC@28211|Alphaproteobacteria,2K0CG@204457|Sphingomonadales 204457|Sphingomonadales F Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth guaB - 1.1.1.205 ko:K00088 ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 M00050 R01130,R08240 RC00143,RC02207 ko00000,ko00001,ko00002,ko01000,ko04147 - - - CBS,IMPDH,NMO k59_563084_1 1229909.NSED_01900 4.74e-119 342.0 COG0605@1|root,arCOG04147@2157|Archaea,41S6C@651137|Thaumarchaeota 651137|Thaumarchaeota P Destroys radicals which are normally produced within the cells and which are toxic to biological systems - - 1.15.1.1 ko:K04564 ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016 - - - ko00000,ko00001,ko01000 - - - Sod_Fe_C,Sod_Fe_N k59_563084_2 436308.Nmar_0393 5.78e-18 84.0 COG1404@1|root,arCOG00702@2157|Archaea,41SX3@651137|Thaumarchaeota 651137|Thaumarchaeota O Belongs to the peptidase S8 family - - - ko:K14647 ko02024,map02024 - - - ko00000,ko00001,ko01000,ko01002,ko03110 - - - PA,Peptidase_S8 k59_1805057_1 338963.Pcar_0515 1.73e-20 88.6 COG2126@1|root,COG2126@2|Bacteria,1MXCS@1224|Proteobacteria,42NVQ@68525|delta/epsilon subdivisions,2WJFT@28221|Deltaproteobacteria,43TVE@69541|Desulfuromonadales 28221|Deltaproteobacteria J Ion transport protein - - - ko:K10716 - - - - ko00000,ko02000 1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6 - - Ion_trans k59_789187_1 1163617.SCD_n00008 1.07e-71 230.0 COG1652@1|root,COG1652@2|Bacteria,1MUBV@1224|Proteobacteria,2VIZJ@28216|Betaproteobacteria 28216|Betaproteobacteria S PFAM Peptidoglycan-binding LysM - - - - - - - - - - - - LysM k59_1015372_1 1411685.U062_00106 4.92e-36 130.0 COG0020@1|root,COG0020@2|Bacteria,1MVP1@1224|Proteobacteria,1RMVX@1236|Gammaproteobacteria,1J5QE@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with (2E,6E)-farnesyl diphosphate (E,E-FPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E,38E)-undecaprenyl diphosphate (di-trans,octa-cis-UPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide uppS GO:0000270,GO:0000287,GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006022,GO:0006023,GO:0006024,GO:0006066,GO:0006629,GO:0006720,GO:0006807,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008834,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0030203,GO:0034645,GO:0042546,GO:0043164,GO:0043167,GO:0043169,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0046872,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 2.5.1.31 ko:K00806 ko00900,ko01110,map00900,map01110 - R06447 RC00279,RC02839 ko00000,ko00001,ko01000,ko01006 - - iECBD_1354.ECBD_3445,iECOK1_1307.ECOK1_0175,iECSE_1348.ECSE_0173,iECW_1372.ECW_m0170,iEKO11_1354.EKO11_3744,iEcDH1_1363.EcDH1_3429,iEcE24377_1341.EcE24377A_0178,iEcHS_1320.EcHS_A0176,iNRG857_1313.NRG857_00890,iSFV_1184.SFV_0157,iUMN146_1321.UM146_23675,iUMNK88_1353.UMNK88_178,iWFL_1372.ECW_m0170,iY75_1357.Y75_RS00880 Prenyltransf k59_1015372_2 1168065.DOK_07314 5.82e-19 82.4 COG0233@1|root,COG0233@2|Bacteria,1N66T@1224|Proteobacteria,1RN75@1236|Gammaproteobacteria,1J5ZJ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another frr GO:0002181,GO:0002184,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0022411,GO:0032984,GO:0034641,GO:0034645,GO:0043021,GO:0043023,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576 - ko:K02838 - - - - ko00000,ko03012 - - - RRF k59_1299055_1 744980.TRICHSKD4_5728 2.13e-142 408.0 COG2801@1|root,COG2963@1|root,COG2801@2|Bacteria,COG2963@2|Bacteria,1PBHA@1224|Proteobacteria,2TRQF@28211|Alphaproteobacteria 28211|Alphaproteobacteria L COG2801 Transposase and inactivated derivatives - - 2.7.7.49 ko:K00986,ko:K07497 - - - - ko00000,ko01000 - - - HTH_32,rve,rve_3 k59_1299058_1 395965.Msil_3774 4.56e-100 313.0 COG1251@1|root,COG1251@2|Bacteria,1MW58@1224|Proteobacteria,2TS8I@28211|Alphaproteobacteria,3NAQ3@45404|Beijerinckiaceae 28211|Alphaproteobacteria C Pyridine nucleotide-disulphide oxidoreductase - - 1.7.1.15 ko:K00362 ko00910,ko01120,map00910,map01120 M00530 R00787 RC00176 ko00000,ko00001,ko00002,ko01000 - - - Fer2_BFD,NIR_SIR,NIR_SIR_ferr,Pyr_redox_2,Rieske_2 k59_1015434_2 575788.VS_0512 2.18e-05 47.8 COG4974@1|root,COG4974@2|Bacteria,1MVNF@1224|Proteobacteria,1RPI8@1236|Gammaproteobacteria,1XT87@135623|Vibrionales 135623|Vibrionales D recombinase XerD xerD GO:0000150,GO:0003674,GO:0003824,GO:0006139,GO:0006259,GO:0006310,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009009,GO:0009987,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:0140097,GO:1901360 - ko:K04763 - - - - ko00000,ko03036 - - - Phage_int_SAM_1,Phage_integrase k59_677859_1 1304872.JAGC01000003_gene3691 1.82e-97 323.0 COG1352@1|root,COG2201@1|root,COG5002@1|root,COG1352@2|Bacteria,COG2201@2|Bacteria,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,42NK9@68525|delta/epsilon subdivisions,2WMCQ@28221|Deltaproteobacteria,2MH9G@213115|Desulfovibrionales 28221|Deltaproteobacteria T response regulator, receiver - - 2.1.1.80,3.1.1.61 ko:K13924 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko02022,ko02035 - - - CheB_methylest,CheR,CheR_N,GAF_2,HATPase_c,HisKA,PAS_10,PAS_3,PAS_4,PAS_9,Response_reg,dCache_3 k59_1805118_1 2340.JV46_04630 1.28e-29 113.0 COG0758@1|root,COG0758@2|Bacteria,1MZGB@1224|Proteobacteria,1S95S@1236|Gammaproteobacteria,1JB42@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria LU Putative molybdenum carrier - - - - - - - - - - - - MoCo_carrier k59_1189264_1 395965.Msil_1419 9.4e-35 119.0 COG1942@1|root,COG1942@2|Bacteria,1NBW3@1224|Proteobacteria,2V2E1@28211|Alphaproteobacteria,3NCUB@45404|Beijerinckiaceae 28211|Alphaproteobacteria S Tautomerase enzyme - - 5.3.2.6 ko:K01821 ko00362,ko00621,ko00622,ko01100,ko01120,ko01220,map00362,map00621,map00622,map01100,map01120,map01220 M00569 R03966,R05389 RC01040,RC01355 ko00000,ko00001,ko00002,ko01000 - - - Tautomerase k59_1189264_2 1280944.HY17_11145 1.94e-53 185.0 COG0457@1|root,COG3710@1|root,COG5616@1|root,COG0457@2|Bacteria,COG3710@2|Bacteria,COG5616@2|Bacteria,1PF3H@1224|Proteobacteria,2V7F9@28211|Alphaproteobacteria,43YSF@69657|Hyphomonadaceae 28211|Alphaproteobacteria K Transcriptional regulatory protein, C terminal - - - - - - - - - - - - TPR_16,Trans_reg_C k59_737721_1 43759.JNWK01000050_gene8170 4.22e-08 60.5 COG0515@1|root,COG0515@2|Bacteria,2GM6E@201174|Actinobacteria 201174|Actinobacteria KLT serine threonine protein kinase pkaA - 2.7.11.1 ko:K08884,ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase k59_1020172_1 1379270.AUXF01000004_gene3278 2.97e-115 339.0 COG0601@1|root,COG0601@2|Bacteria,1ZSXJ@142182|Gemmatimonadetes 142182|Gemmatimonadetes U Binding-protein-dependent transport system inner membrane component - - - ko:K02033 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1 k59_398456_1 1229909.NSED_09835 1.12e-117 342.0 COG1100@1|root,arCOG01225@2157|Archaea,41T0A@651137|Thaumarchaeota 651137|Thaumarchaeota S Conserved hypothetical ATP binding protein - - - ko:K06883 - - - - ko00000 - - - ATP_bind_1 k59_398456_2 1229909.NSED_09840 1.62e-73 230.0 COG0392@1|root,arCOG00899@2157|Archaea,41SFV@651137|Thaumarchaeota 651137|Thaumarchaeota S Lysylphosphatidylglycerol synthase TM region - - - ko:K07027 - - - - ko00000,ko02000 4.D.2 - - LPG_synthase_TM k59_172713_1 316407.4062664 6.58e-147 422.0 COG0304@1|root,COG0304@2|Bacteria,1MU1X@1224|Proteobacteria,1RMDE@1236|Gammaproteobacteria,3XMVA@561|Escherichia 1236|Gammaproteobacteria I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP fabF GO:0003674,GO:0003824,GO:0004312,GO:0004315,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0032787,GO:0033817,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:0072330,GO:1901576 2.3.1.179 ko:K09458 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119 RC00039,RC02728,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - iAF1260.b1095,iAPECO1_1312.APECO1_176,iB21_1397.B21_01099,iBWG_1329.BWG_0943,iE2348C_1286.E2348C_1187,iEC042_1314.EC042_1165,iEC55989_1330.EC55989_1207,iECABU_c1320.ECABU_c13085,iECBD_1354.ECBD_2506,iECB_1328.ECB_01091,iECDH10B_1368.ECDH10B_1167,iECDH1ME8569_1439.ECDH1ME8569_1030,iECD_1391.ECD_01091,iECED1_1282.ECED1_1238,iECH74115_1262.ECH74115_1474,iECIAI1_1343.ECIAI1_1130,iECIAI39_1322.ECIAI39_2066,iECO103_1326.ECO103_1140,iECO111_1330.ECO111_1372,iECO26_1355.ECO26_1428,iECOK1_1307.ECOK1_1202,iECP_1309.ECP_1087,iECS88_1305.ECS88_1109,iECSE_1348.ECSE_1159,iECSF_1327.ECSF_0994,iECSP_1301.ECSP_1396,iECUMN_1333.ECUMN_1270,iECW_1372.ECW_m1203,iECs_1301.ECs1473,iEKO11_1354.EKO11_2739,iETEC_1333.ETEC_1160,iEcDH1_1363.EcDH1_2552,iEcE24377_1341.EcE24377A_1216,iEcSMS35_1347.EcSMS35_2032,iG2583_1286.G2583_1355,iJO1366.b1095,iJR904.b1095,iLF82_1304.LF82_0607,iNRG857_1313.NRG857_05280,iSF_1195.SF1099,iSFxv_1172.SFxv_1251,iS_1188.S1179,iUMN146_1321.UM146_11850,iWFL_1372.ECW_m1203,iY75_1357.Y75_RS05720,iZ_1308.Z1734,ic_1306.c1365 Ketoacyl-synt_C,ketoacyl-synt k59_1020173_1 1232437.KL662042_gene1993 3.42e-35 127.0 COG2761@1|root,COG2761@2|Bacteria,1NXUB@1224|Proteobacteria,42TBH@68525|delta/epsilon subdivisions,2WPJ5@28221|Deltaproteobacteria,2MK76@213118|Desulfobacterales 28221|Deltaproteobacteria Q DSBA-like thioredoxin domain - - - - - - - - - - - - DSBA k59_1020173_2 395495.Lcho_2418 2.8e-14 72.4 COG0015@1|root,COG0015@2|Bacteria,1MXNN@1224|Proteobacteria,2VID3@28216|Betaproteobacteria,1KKNG@119065|unclassified Burkholderiales 28216|Betaproteobacteria F Adenylosuccinate lyase C-terminus - - 5.5.1.2 ko:K01857 ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220 - R03307 RC00902 ko00000,ko00001,ko01000 - - - ADSL_C,Lyase_1 k59_398468_1 1229909.NSED_07065 2.05e-98 298.0 COG1027@1|root,arCOG01750@2157|Archaea,41S9C@651137|Thaumarchaeota 651137|Thaumarchaeota E Fumarase C C-terminus - - 4.3.1.1 ko:K01744 ko00250,ko01100,map00250,map01100 - R00490 RC00316,RC02799 ko00000,ko00001,ko01000 - - - FumaraseC_C,Lyase_1 k59_794104_1 1122137.AQXF01000002_gene544 2.79e-112 331.0 COG4757@1|root,COG4757@2|Bacteria,1RI0P@1224|Proteobacteria 1224|Proteobacteria S Serine aminopeptidase, S33 - - - - - - - - - - - - Hydrolase_4 k59_1697755_1 1122137.AQXF01000003_gene2297 3e-45 166.0 COG0206@1|root,COG0206@2|Bacteria,1MV2X@1224|Proteobacteria,2TS1Q@28211|Alphaproteobacteria 28211|Alphaproteobacteria D Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity ftsZ - - ko:K03531 ko04112,map04112 - - - ko00000,ko00001,ko02048,ko03036,ko04812 - - - FtsZ_C,Tubulin k59_624353_1 497321.C664_10148 1.86e-98 297.0 COG1533@1|root,COG1533@2|Bacteria,1MW0H@1224|Proteobacteria,2VIYE@28216|Betaproteobacteria,2KUH2@206389|Rhodocyclales 206389|Rhodocyclales L Elongator protein 3, MiaB family, Radical SAM - - - - - - - - - - - - Radical_SAM k59_737739_2 83406.HDN1F_03740 2.07e-33 117.0 COG0186@1|root,COG0186@2|Bacteria,1MZIK@1224|Proteobacteria,1S8SS@1236|Gammaproteobacteria,1J6GF@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA rpsQ GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042221,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046677,GO:0050896,GO:0065003,GO:0070181,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02961 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S17 k59_737739_3 1453501.JELR01000005_gene1729 1.59e-15 70.1 COG0255@1|root,COG0255@2|Bacteria,1N6PR@1224|Proteobacteria,1SCBN@1236|Gammaproteobacteria,468D6@72275|Alteromonadaceae 1236|Gammaproteobacteria J Belongs to the universal ribosomal protein uL29 family rpmC GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02904 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L29 k59_624358_2 94624.Bpet4910 2.79e-78 248.0 COG0337@1|root,COG0337@2|Bacteria,1MUBK@1224|Proteobacteria,2VHXR@28216|Betaproteobacteria,3T1P8@506|Alcaligenaceae 28216|Betaproteobacteria E Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) aroB - 2.7.1.71,4.2.3.4 ko:K01735,ko:K13829 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02412,R03083 RC00002,RC00078,RC00847 ko00000,ko00001,ko00002,ko01000 - - - DHQ_synthase,SKI k59_454929_1 436308.Nmar_1501 1.64e-55 176.0 arCOG10586@1|root,arCOG10586@2157|Archaea,41STH@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1020195_1 1122137.AQXF01000001_gene3004 1.01e-128 388.0 COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,1MWGR@1224|Proteobacteria,2TRTE@28211|Alphaproteobacteria 28211|Alphaproteobacteria EU COG1506 Dipeptidyl aminopeptidases acylaminoacyl-peptidases - - - - - - - - - - - - PD40,Peptidase_S9 k59_680802_1 1279038.KB907340_gene1548 3.17e-38 135.0 COG1999@1|root,COG1999@2|Bacteria,1RHJ8@1224|Proteobacteria,2U0Q3@28211|Alphaproteobacteria,2JSPF@204441|Rhodospirillales 204441|Rhodospirillales S protein SCO1 SenC PrrC, involved in biogenesis of respiratory and photosynthetic systems - - - ko:K07152 - - - - ko00000,ko03029 - - - SCO1-SenC k59_1415215_1 1415778.JQMM01000001_gene626 5.69e-98 306.0 COG1200@1|root,COG1200@2|Bacteria,1MWN2@1224|Proteobacteria,1RMMQ@1236|Gammaproteobacteria,1J4VK@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) recG GO:0003674,GO:0003678,GO:0003724,GO:0003824,GO:0004003,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006807,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0008186,GO:0009314,GO:0009379,GO:0009628,GO:0009987,GO:0010501,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0032991,GO:0033202,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0051276,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:0140098,GO:1901360,GO:1902494 3.6.4.12 ko:K03655 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,Helicase_C,RecG_wedge k59_850497_1 397948.Cmaq_0355 1.94e-12 67.4 COG0454@1|root,arCOG00845@2157|Archaea 2157|Archaea K COG0454 Histone acetyltransferase HPA2 and related acetyltransferases - - 2.3.1.82 ko:K18816 - - - - br01600,ko00000,ko01000,ko01504 - - - Acetyltransf_1 k59_850497_2 1231190.NA8A_14719 1.41e-46 162.0 COG0022@1|root,COG0022@2|Bacteria,1R8KB@1224|Proteobacteria,2TRFK@28211|Alphaproteobacteria,43HIU@69277|Phyllobacteriaceae 28211|Alphaproteobacteria C COG0022 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit - - - ko:K21417 - - - - ko00000,ko01000 - - - Transket_pyr,Transketolase_C k59_398497_2 204669.Acid345_3738 6.84e-42 145.0 COG1028@1|root,COG1028@2|Bacteria,3Y2SE@57723|Acidobacteria,2JKTX@204432|Acidobacteriia 204432|Acidobacteriia IQ PFAM Short-chain dehydrogenase reductase SDR - - - - - - - - - - - - adh_short_C2 k59_1302498_1 1128912.GMES_1695 6.86e-74 245.0 COG1048@1|root,COG1048@2|Bacteria,1MU9T@1224|Proteobacteria,1RN5I@1236|Gammaproteobacteria,465HN@72275|Alteromonadaceae 1236|Gammaproteobacteria C Catalyzes the isomerization of citrate to isocitrate via cis-aconitate acnA GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003730,GO:0003824,GO:0003994,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006081,GO:0006082,GO:0006091,GO:0006097,GO:0006099,GO:0006101,GO:0006629,GO:0006631,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009060,GO:0009061,GO:0009987,GO:0015980,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017144,GO:0019541,GO:0019679,GO:0019752,GO:0032787,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044255,GO:0044262,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0046459,GO:0046487,GO:0046872,GO:0046914,GO:0047456,GO:0048037,GO:0050896,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0071704,GO:0072350,GO:0097159,GO:1901363 4.2.1.3 ko:K01681 ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00173,M00740 R01324,R01325,R01900 RC00497,RC00498,RC00618 br01601,ko00000,ko00001,ko00002,ko01000 - - iAPECO1_1312.APECO1_436,iECOK1_1307.ECOK1_1491,iECS88_1305.ECS88_1416,iJN746.PP_2112,iUMN146_1321.UM146_10390,iUTI89_1310.UTI89_C1547 Aconitase,Aconitase_C k59_1584677_4 1218352.B597_019440 1.3e-21 90.5 COG4570@1|root,COG4570@2|Bacteria,1N92D@1224|Proteobacteria,1TA3B@1236|Gammaproteobacteria,1Z47G@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria L Endodeoxyribonuclease RusA - - - - - - - - - - - - RusA k59_794116_1 1125863.JAFN01000001_gene865 2.64e-08 59.3 COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,42NB6@68525|delta/epsilon subdivisions,2WIWE@28221|Deltaproteobacteria 28221|Deltaproteobacteria M Belongs to the peptidase S1C family degP-2 - 3.4.21.107 ko:K04771 ko01503,ko02020,map01503,map02020 M00728 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 - - - PDZ_2,Trypsin_2 k59_568072_1 1120999.JONM01000003_gene2534 4.43e-72 231.0 COG2115@1|root,COG2115@2|Bacteria,1MXS2@1224|Proteobacteria,2VNPT@28216|Betaproteobacteria 28216|Betaproteobacteria G Belongs to the xylose isomerase family xylA - 5.3.1.5 ko:K01805 ko00040,ko00051,ko01100,map00040,map00051,map01100 - R00878,R01432 RC00376,RC00516 ko00000,ko00001,ko01000 - - - - k59_1076064_1 396588.Tgr7_3178 6.02e-76 246.0 COG0469@1|root,COG0469@2|Bacteria,1NNNX@1224|Proteobacteria,1RYF5@1236|Gammaproteobacteria,1X04N@135613|Chromatiales 135613|Chromatiales G PFAM Pyruvate kinase barrel - - 2.7.1.40 ko:K00873 ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230 M00001,M00002,M00049,M00050 R00200,R00430,R01138,R01858,R02320 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - PK k59_963325_1 391615.ABSJ01000034_gene1035 2.72e-27 106.0 COG0152@1|root,COG0152@2|Bacteria,1MUR9@1224|Proteobacteria,1RNNY@1236|Gammaproteobacteria,1J4E7@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria F COG0152 Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase purC GO:0003674,GO:0003824,GO:0004639,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006188,GO:0006189,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.2.6 ko:K01923 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04591 RC00064,RC00162 ko00000,ko00001,ko00002,ko01000 - - iAF1260.b2476,iB21_1397.B21_02330,iBWG_1329.BWG_2240,iE2348C_1286.E2348C_2713,iEC042_1314.EC042_2677,iEC55989_1330.EC55989_2759,iECABU_c1320.ECABU_c27880,iECBD_1354.ECBD_1213,iECB_1328.ECB_02368,iECDH10B_1368.ECDH10B_2642,iECDH1ME8569_1439.ECDH1ME8569_2402,iECDH1ME8569_1439.EcDH1_1193,iECD_1391.ECD_02368,iECED1_1282.ECED1_2911,iECH74115_1262.ECH74115_3698,iECIAI1_1343.ECIAI1_2527,iECNA114_1301.ECNA114_2561,iECO103_1326.ECO103_2988,iECO111_1330.ECO111_3199,iECO26_1355.ECO26_3522,iECOK1_1307.ECOK1_2784,iECP_1309.ECP_2490,iECS88_1305.ECS88_2658,iECSE_1348.ECSE_2760,iECSF_1327.ECSF_2329,iECSP_1301.ECSP_3415,iECUMN_1333.ECUMN_2789,iECW_1372.ECW_m2698,iECs_1301.ECs3338,iEKO11_1354.EKO11_1259,iETEC_1333.ETEC_2581,iEcDH1_1363.EcDH1_1193,iEcE24377_1341.EcE24377A_2757,iEcHS_1320.EcHS_A2607,iEcSMS35_1347.EcSMS35_2623,iEcolC_1368.EcolC_1200,iG2583_1286.G2583_2999,iJN746.PP_1240,iJO1366.b2476,iJR904.b2476,iLF82_1304.LF82_1775,iNRG857_1313.NRG857_12360,iSFV_1184.SFV_2521,iSF_1195.SF2519,iSFxv_1172.SFxv_2773,iS_1188.S2669,iSbBS512_1146.SbBS512_E2848,iUMNK88_1353.UMNK88_3071,iWFL_1372.ECW_m2698,iY75_1357.Y75_RS12925,iYL1228.KPN_02810,iZ_1308.Z3735 SAICAR_synt k59_963325_2 1198232.CYCME_2436 7.51e-10 61.2 COG0741@1|root,COG1388@1|root,COG0741@2|Bacteria,COG1388@2|Bacteria,1MWKE@1224|Proteobacteria,1RMFZ@1236|Gammaproteobacteria 1236|Gammaproteobacteria M COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains) mltD - - ko:K08307 - - - - ko00000,ko01000,ko01011 - - - LysM,SLT k59_1697793_1 1415778.JQMM01000001_gene2205 6.32e-107 320.0 COG0527@1|root,COG0527@2|Bacteria,1MW3H@1224|Proteobacteria,1RN1G@1236|Gammaproteobacteria,1J4D1@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Belongs to the aspartokinase family lysC GO:0003674,GO:0003824,GO:0004072,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0019202,GO:0044237 2.7.2.4 ko:K00928 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00017,M00018,M00033,M00525,M00526,M00527 R00480 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase,ACT,ACT_7 k59_1641426_1 551275.KB899545_gene2739 2.11e-27 104.0 COG0605@1|root,COG0605@2|Bacteria,1MVW2@1224|Proteobacteria,2TU3T@28211|Alphaproteobacteria,43WEZ@69657|Hyphomonadaceae 28211|Alphaproteobacteria P Destroys radicals which are normally produced within the cells and which are toxic to biological systems sodB - 1.15.1.1 ko:K04564 ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016 - - - ko00000,ko00001,ko01000 - - - Sod_Fe_C,Sod_Fe_N k59_1641426_2 1122137.AQXF01000002_gene265 7.13e-28 105.0 COG0663@1|root,COG0663@2|Bacteria,1RD76@1224|Proteobacteria,2U5GR@28211|Alphaproteobacteria 28211|Alphaproteobacteria S COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily yrdA - - - - - - - - - - - Hexapep k59_1754258_1 1279017.AQYJ01000027_gene1584 1.2e-29 122.0 COG4796@1|root,COG4796@2|Bacteria,1QTT6@1224|Proteobacteria,1RN3Z@1236|Gammaproteobacteria,465HK@72275|Alteromonadaceae 1236|Gammaproteobacteria U COG4796 Type II secretory pathway, component HofQ pilQ GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006139,GO:0006259,GO:0006308,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0015976,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901361,GO:1901363,GO:1901575 - ko:K02507,ko:K02666 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - AMIN,STN,Secretin,Secretin_N k59_228869_1 1415778.JQMM01000001_gene500 9.22e-91 288.0 COG1109@1|root,COG1109@2|Bacteria,1MUA5@1224|Proteobacteria,1RMU8@1236|Gammaproteobacteria,1J5ED@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria G COG1109 Phosphomannomutase algC GO:0003674,GO:0003824,GO:0004615,GO:0005975,GO:0008150,GO:0008152,GO:0016853,GO:0016866,GO:0016868,GO:0044238,GO:0071704 5.4.2.2,5.4.2.8 ko:K01840,ko:K15778 ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130 M00114 R00959,R01057,R01818,R08639 RC00408 ko00000,ko00001,ko00002,ko01000 - - - PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV k59_1302517_1 1122137.AQXF01000003_gene2283 1.1e-27 103.0 COG2001@1|root,COG2001@2|Bacteria,1RHCG@1224|Proteobacteria,2UD3W@28211|Alphaproteobacteria 28211|Alphaproteobacteria K Belongs to the MraZ family mraZ - - ko:K03925 - - - - ko00000 - - - MraZ k59_737797_3 1121272.KB903283_gene4923 2.83e-26 100.0 COG0346@1|root,COG0346@2|Bacteria,2IFMD@201174|Actinobacteria,4DM35@85008|Micromonosporales 201174|Actinobacteria E lactoylglutathione lyase activity - - - - - - - - - - - - - k59_511380_1 316407.85674635 2.07e-85 272.0 COG3127@1|root,COG3127@2|Bacteria,1MU9R@1224|Proteobacteria,1RM8Y@1236|Gammaproteobacteria,3XMBI@561|Escherichia 1236|Gammaproteobacteria Q FtsX-like permease family ybbP GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX k59_511380_2 316407.85674634 2e-12 64.7 COG4181@1|root,COG4181@2|Bacteria,1MXG9@1224|Proteobacteria,1RMG1@1236|Gammaproteobacteria,3XMIH@561|Escherichia 1236|Gammaproteobacteria P ATP-binding protein YbbA ybbA GO:0000166,GO:0003674,GO:0005488,GO:0005524,GO:0008144,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_172787_1 107636.JQNK01000009_gene2382 5.24e-105 319.0 COG1251@1|root,COG2710@1|root,COG1251@2|Bacteria,COG2710@2|Bacteria,1MWAJ@1224|Proteobacteria,2TQUV@28211|Alphaproteobacteria,36ZI6@31993|Methylocystaceae 28211|Alphaproteobacteria C Nitrogenase component 1 type Oxidoreductase nifE - - ko:K02587 - - - - ko00000 - - - Fer2_BFD,Oxidored_nitro k59_398554_1 82996.sch_02610 4.66e-73 231.0 COG0270@1|root,COG0270@2|Bacteria,1MV9H@1224|Proteobacteria,1S054@1236|Gammaproteobacteria,403XF@613|Serratia 1236|Gammaproteobacteria L C-5 cytosine-specific DNA methylase - - 2.1.1.37 ko:K00558 ko00270,ko01100,ko05206,map00270,map01100,map05206 M00035 R04858 RC00003,RC00332 ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036 - - - DNA_methylase k59_398554_2 765698.Mesci_2774 2.19e-103 333.0 COG0323@1|root,COG4191@1|root,COG0323@2|Bacteria,COG4191@2|Bacteria,1ND4X@1224|Proteobacteria,2U54V@28211|Alphaproteobacteria,43P11@69277|Phyllobacteriaceae 28211|Alphaproteobacteria T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - HATPase_c,HATPase_c_3 k59_850562_1 519989.ECTPHS_08823 1.28e-21 91.3 COG0224@1|root,COG0224@2|Bacteria,1MU28@1224|Proteobacteria,1RNWJ@1236|Gammaproteobacteria,1WW4K@135613|Chromatiales 135613|Chromatiales C Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex atpG - - ko:K02115 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt k59_850562_2 1177154.Y5S_02609 1.02e-65 213.0 COG0055@1|root,COG0055@2|Bacteria,1MUFU@1224|Proteobacteria,1RN6U@1236|Gammaproteobacteria,1XIMC@135619|Oceanospirillales 135619|Oceanospirillales C Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits atpD - 3.6.3.14 ko:K02112 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - - ATP-synt_ab,ATP-synt_ab_N k59_1302544_1 436308.Nmar_0067 1.43e-142 429.0 COG1615@1|root,arCOG06128@2157|Archaea,41SCS@651137|Thaumarchaeota 651137|Thaumarchaeota S Uncharacterised protein family (UPF0182) - - - ko:K09118 - - - - ko00000 - - - UPF0182 k59_1415287_1 1229909.NSED_08270 1.41e-105 306.0 arCOG08675@1|root,arCOG08675@2157|Archaea,41SI5@651137|Thaumarchaeota 651137|Thaumarchaeota C Monooxygenase subunit B protein - - - ko:K10945 ko00680,ko00910,ko01100,ko01120,ko01200,map00680,map00910,map01100,map01120,map01200 M00174,M00528,M00804 R00148,R09518 RC00173,RC02797 ko00000,ko00001,ko00002 - - - Monooxygenase_B k59_59862_1 1177928.TH2_10989 6.45e-129 382.0 COG0129@1|root,COG0129@2|Bacteria,1MV4I@1224|Proteobacteria,2TQRW@28211|Alphaproteobacteria,2JQ3R@204441|Rhodospirillales 204441|Rhodospirillales EG Belongs to the IlvD Edd family - - 4.2.1.25 ko:K13875 ko00053,ko01100,map00053,map01100 - R02522 RC00543 ko00000,ko00001,ko01000 - - - ILVD_EDD k59_1415289_1 1144305.PMI02_00141 1.91e-68 220.0 COG5361@1|root,COG5361@2|Bacteria,1R8Y7@1224|Proteobacteria,2UPHX@28211|Alphaproteobacteria,2K48D@204457|Sphingomonadales 204457|Sphingomonadales S Conserved Protein - - - - - - - - - - - - DUF1214 k59_342256_1 316407.85675434 4.78e-38 132.0 COG2976@1|root,COG2976@2|Bacteria,1N117@1224|Proteobacteria,1S95P@1236|Gammaproteobacteria,3XMCB@561|Escherichia 1236|Gammaproteobacteria S Tetratricopeptide repeat-like domain yfgM GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0009897,GO:0009986,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0031233,GO:0044425,GO:0044459,GO:0044464,GO:0071575,GO:0071944,GO:0098552 - - - - - - - - - - TPR_21 k59_342256_2 316407.1805571 4.67e-103 307.0 COG1520@1|root,COG1520@2|Bacteria,1MXIJ@1224|Proteobacteria,1RN4V@1236|Gammaproteobacteria,3XN9I@561|Escherichia 1236|Gammaproteobacteria M Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane bamB GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0008104,GO:0008150,GO:0008152,GO:0009279,GO:0009987,GO:0016020,GO:0016043,GO:0016491,GO:0019867,GO:0022607,GO:0030312,GO:0030313,GO:0031224,GO:0031230,GO:0031241,GO:0031246,GO:0031975,GO:0032991,GO:0033036,GO:0034613,GO:0042802,GO:0043163,GO:0043165,GO:0044085,GO:0044091,GO:0044425,GO:0044462,GO:0044464,GO:0045184,GO:0045229,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0055114,GO:0061024,GO:0070727,GO:0071709,GO:0071840,GO:0071944,GO:0072657,GO:0090150,GO:0098552,GO:0098796,GO:1990063 - ko:K17713 - - - - ko00000,ko02000 1.B.33.1 - - PQQ_2,PQQ_3 k59_1754320_2 420246.GTNG_2830 7.53e-21 90.5 2DRIA@1|root,33BX1@2|Bacteria,1VY3D@1239|Firmicutes,4HX43@91061|Bacilli,1WHEN@129337|Geobacillus 91061|Bacilli - - - - - - - - - - - - - - - k59_1697855_1 1116472.MGMO_105c00370 4.04e-65 215.0 COG3267@1|root,COG3409@1|root,COG3267@2|Bacteria,COG3409@2|Bacteria,1MU3G@1224|Proteobacteria,1RMI0@1236|Gammaproteobacteria,1XERT@135618|Methylococcales 135618|Methylococcales U SMART ATPase, AAA type, core - - - ko:K02450 - M00331 - - ko00000,ko00002,ko02044 9.B.42 - - AAA_22,PG_binding_1 k59_1528444_1 436308.Nmar_1295 7.09e-175 490.0 COG0189@1|root,arCOG01589@2157|Archaea,41SE8@651137|Thaumarchaeota 651137|Thaumarchaeota H Lysine biosynthesis - - 6.3.2.43 ko:K05827 ko00300,ko01100,ko01210,ko01230,map00300,map01100,map01210,map01230 M00031 R09775 RC00064,RC00090 ko00000,ko00001,ko00002,ko01000 - - - RimK k59_1528444_2 436308.Nmar_1296 1.17e-25 103.0 COG0624@1|root,arCOG01107@2157|Archaea,41SAX@651137|Thaumarchaeota 651137|Thaumarchaeota E Catalyzes the release of L-lysine from LysW -gamma-L- lysine and the release of L-ornithine from LysW -L-ornithine lysK - - ko:K05831 ko00220,ko00300,ko01100,ko01210,ko01230,map00220,map00300,map01100,map01210,map01230 M00031,M00763 R09779,R10933 RC00064,RC00090 ko00000,ko00001,ko00002 - - - M20_dimer,Peptidase_M20 k59_1132903_2 349124.Hhal_1200 1.12e-62 206.0 COG0253@1|root,COG0253@2|Bacteria,1MWDH@1224|Proteobacteria,1RMGV@1236|Gammaproteobacteria,1WVYQ@135613|Chromatiales 135613|Chromatiales E Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan dapF - 5.1.1.7 ko:K01778 ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00527 R02735 RC00302 ko00000,ko00001,ko00002,ko01000 - - - DAP_epimerase k59_1471977_1 1121033.AUCF01000001_gene1998 1.16e-19 93.2 COG0642@1|root,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,2TXJ2@28211|Alphaproteobacteria,2JPEA@204441|Rhodospirillales 204441|Rhodospirillales T Histidine kinase - - - - - - - - - - - - HATPase_c,HisKA,Hpt,PAS,PAS_4,PAS_7,Response_reg k59_455014_1 1056816.JAFQ01000004_gene2206 5.21e-50 172.0 COG4638@1|root,COG4638@2|Bacteria,2GKJY@201174|Actinobacteria,4FWEJ@85025|Nocardiaceae 201174|Actinobacteria P Ring hydroxylating alpha subunit (catalytic domain) - - - - - - - - - - - - Rieske,Ring_hydroxyl_A k59_1641509_1 443218.AS9A_2007 3.36e-34 130.0 COG4122@1|root,COG4122@2|Bacteria,2GJGI@201174|Actinobacteria,233XE@1762|Mycobacteriaceae 201174|Actinobacteria S proteasome accessory factor PafA2 dop GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0006464,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0010498,GO:0016787,GO:0016810,GO:0016811,GO:0017076,GO:0018193,GO:0018205,GO:0019538,GO:0019941,GO:0030163,GO:0030554,GO:0032446,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0036211,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0051603,GO:0070490,GO:0070647,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575 3.5.1.119 ko:K20814 - - - - ko00000,ko01000,ko03051 - - - Pup_ligase k59_1641509_2 1122138.AQUZ01000001_gene1627 3.06e-05 45.1 2E9C2@1|root,333JS@2|Bacteria,2IQ5V@201174|Actinobacteria,4DSCX@85009|Propionibacteriales 201174|Actinobacteria S Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation pup GO:0003674,GO:0005488,GO:0006464,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0010498,GO:0018193,GO:0018205,GO:0019538,GO:0019941,GO:0030163,GO:0031386,GO:0032446,GO:0036211,GO:0040007,GO:0043170,GO:0043412,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044877,GO:0051603,GO:0070490,GO:0070628,GO:0070647,GO:0071704,GO:1901564,GO:1901565,GO:1901575 - ko:K13570 - - - - ko00000,ko04121 - - - Pup k59_1189413_1 1049564.TevJSym_as00710 1.33e-14 73.9 COG0373@1|root,COG0373@2|Bacteria,1MU41@1224|Proteobacteria,1RNQ8@1236|Gammaproteobacteria,1J5GP@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) hemA GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006082,GO:0006520,GO:0006536,GO:0006725,GO:0006778,GO:0006779,GO:0006782,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0008883,GO:0009058,GO:0009064,GO:0009987,GO:0016491,GO:0016620,GO:0016903,GO:0018130,GO:0019353,GO:0019438,GO:0019752,GO:0033013,GO:0033014,GO:0033526,GO:0034641,GO:0042168,GO:0042440,GO:0042802,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046148,GO:0046483,GO:0046501,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0140098,GO:0140101,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 1.2.1.70 ko:K02492 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R04109 RC00055,RC00149 ko00000,ko00001,ko00002,ko01000 - - iECNA114_1301.ECNA114_1375,iECSF_1327.ECSF_1186,iUTI89_1310.UTI89_C1404 GlutR_N,GlutR_dimer,Shikimate_DH k59_1189413_2 1122201.AUAZ01000012_gene1381 7.33e-24 100.0 COG0216@1|root,COG0216@2|Bacteria,1MV28@1224|Proteobacteria,1RM7Q@1236|Gammaproteobacteria,464HV@72275|Alteromonadaceae 1236|Gammaproteobacteria J Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA prfA GO:0003674,GO:0003676,GO:0003723,GO:0003747,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008079,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0016149,GO:0019538,GO:0022411,GO:0032984,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - ko:K02835 - - - - ko00000,ko03012 - - - PCRF,RF-1 k59_568152_1 522306.CAP2UW1_4328 2.04e-119 357.0 COG4799@1|root,COG4799@2|Bacteria,1MVAX@1224|Proteobacteria,2VI77@28216|Betaproteobacteria,1KQJI@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria I Carboxyl transferase domain accB - 6.4.1.4 ko:K01969 ko00280,ko01100,map00280,map01100 M00036 R04138 RC00367,RC00942 ko00000,ko00001,ko00002,ko01000 - - - Carboxyl_trans k59_1641518_1 316407.1742775 1.67e-157 444.0 COG1917@1|root,COG2207@1|root,COG1917@2|Bacteria,COG2207@2|Bacteria,1MXC6@1224|Proteobacteria,1RZKV@1236|Gammaproteobacteria,3XNJU@561|Escherichia 1236|Gammaproteobacteria K Transcriptional regulator ydiP GO:0003674,GO:0003700,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031326,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901576,GO:1903506,GO:2000112,GO:2001141 - - - - - - - - - - AraC_binding,Cupin_2,HTH_18 k59_59889_1 1437882.AZRU01000020_gene6107 1.21e-170 491.0 COG2159@1|root,COG2159@2|Bacteria,1PZ2X@1224|Proteobacteria,1TBU9@1236|Gammaproteobacteria,1YJ2X@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria S Amidohydrolase - - - - - - - - - - - - Amidohydro_2 k59_398586_1 1123060.JONP01000001_gene1386 1.09e-129 385.0 COG0662@1|root,COG0836@1|root,COG0662@2|Bacteria,COG0836@2|Bacteria,1MV39@1224|Proteobacteria,2TT0R@28211|Alphaproteobacteria,2JRI0@204441|Rhodospirillales 204441|Rhodospirillales GM Belongs to the mannose-6-phosphate isomerase type 2 family cpsB - 2.7.7.13,5.3.1.8 ko:K16011 ko00051,ko00520,ko01100,ko01110,ko01130,ko02025,map00051,map00520,map01100,map01110,map01130,map02025 M00114,M00362 R00885,R01819 RC00002,RC00376 ko00000,ko00001,ko00002,ko01000 - - - MannoseP_isomer,NTP_transferase k59_511442_1 1449126.JQKL01000021_gene72 6.7e-19 90.1 COG0768@1|root,COG0768@2|Bacteria,1TP93@1239|Firmicutes,248KB@186801|Clostridia,26862@186813|unclassified Clostridiales 186801|Clostridia M Penicillin-binding Protein dimerisation domain spoVD - - ko:K08384 ko00550,map00550 - - - ko00000,ko00001,ko01011 - - - PASTA,PBP_dimer,Transpeptidase k59_511442_2 42565.FP66_00220 0.000826 43.1 COG0769@1|root,COG0769@2|Bacteria,1MU6P@1224|Proteobacteria,1RMD6@1236|Gammaproteobacteria,1XHNY@135619|Oceanospirillales 135619|Oceanospirillales M Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan murE - 6.3.2.13 ko:K01928 ko00300,ko00550,map00300,map00550 - R02788 RC00064,RC00090 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_1303532_1 1229909.NSED_06530 1.24e-39 147.0 arCOG08764@1|root,arCOG08764@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_1190498_1 321332.CYB_0507 4.01e-54 196.0 COG0642@1|root,COG2203@1|root,COG0642@2|Bacteria,COG2203@2|Bacteria,COG2205@2|Bacteria,1G09B@1117|Cyanobacteria,1GYFK@1129|Synechococcus 1117|Cyanobacteria T Histidine kinase - - - - - - - - - - - - CHASE3,GAF,GAF_2,HATPase_c,HisKA,Hpt,PAS,PAS_3,PAS_4,PAS_9,Response_reg k59_1133914_1 1121877.JQKF01000009_gene580 1.3e-44 159.0 COG0649@1|root,COG0649@2|Bacteria,2GKEZ@201174|Actinobacteria,4CMP9@84992|Acidimicrobiia 84992|Acidimicrobiia C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient - - 1.6.5.3 ko:K00333 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_49kDa k59_1077216_1 1042377.AFPJ01000037_gene2954 1.93e-48 168.0 COG0025@1|root,COG0025@2|Bacteria,1MW5T@1224|Proteobacteria,1RPH6@1236|Gammaproteobacteria,467E9@72275|Alteromonadaceae 1236|Gammaproteobacteria P COG0025 NhaP-type Na H and K H antiporters nhaP - - ko:K03316 - - - - ko00000 2.A.36 - - Na_H_Exchanger,cNMP_binding k59_117322_1 1122137.AQXF01000002_gene448 4.59e-10 59.3 COG0179@1|root,COG0179@2|Bacteria,1MV0V@1224|Proteobacteria,2TQYU@28211|Alphaproteobacteria 28211|Alphaproteobacteria Q COG0179 2-keto-4-pentenoate hydratase 2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) - - 3.7.1.2 ko:K16171 ko00350,ko00643,ko01100,ko01120,map00350,map00643,map01100,map01120 M00044 R01364 RC00326,RC00446 ko00000,ko00001,ko00002,ko01000 - - - FAA_hydrolase k59_117322_2 1122137.AQXF01000002_gene449 4.46e-104 303.0 COG0346@1|root,COG0346@2|Bacteria,1MWCV@1224|Proteobacteria,2TTXE@28211|Alphaproteobacteria 28211|Alphaproteobacteria E glyoxalase - - - ko:K08234 - - - - ko00000 - - - Glyoxalase k59_527574_2 1229909.NSED_08890 1.56e-121 355.0 COG0183@1|root,arCOG01278@2157|Archaea,41SCI@651137|Thaumarchaeota 651137|Thaumarchaeota I Thiolase, N-terminal domain - - 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N k59_1206501_1 1415778.JQMM01000001_gene982 3.87e-112 328.0 COG0289@1|root,COG0289@2|Bacteria,1MUCT@1224|Proteobacteria,1RMCZ@1236|Gammaproteobacteria,1J4SJ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate dapB GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008839,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0019752,GO:0019877,GO:0042802,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.17.1.8 ko:K00215 ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R04198,R04199 RC00478 ko00000,ko00001,ko00002,ko01000 - - iSbBS512_1146.SbBS512_E0035 DapB_C,DapB_N k59_1319607_1 984262.SGRA_0462 2.27e-48 168.0 COG3488@1|root,COG3488@2|Bacteria,4NGBS@976|Bacteroidetes,1IWE8@117747|Sphingobacteriia 976|Bacteroidetes C Di-haem oxidoreductase, putative peroxidase - - - - - - - - - - - - DHOR k59_1714745_1 580332.Slit_0533 3.77e-60 206.0 COG2114@1|root,COG4252@1|root,COG2114@2|Bacteria,COG4252@2|Bacteria,1MV1V@1224|Proteobacteria,2VJ72@28216|Betaproteobacteria 28216|Betaproteobacteria T Adenylyl cyclase class-3 4 guanylyl cyclase cyaA - 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 - - - CHASE2,Guanylate_cyc k59_1601968_1 1379270.AUXF01000006_gene233 2.74e-67 209.0 COG1905@1|root,COG1905@2|Bacteria,1ZTJ9@142182|Gemmatimonadetes 142182|Gemmatimonadetes C Thioredoxin-like [2Fe-2S] ferredoxin - - 1.6.5.3 ko:K00334 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - 2Fe-2S_thioredx k59_1601968_2 1379270.AUXF01000006_gene232 0.000397 42.0 COG0649@1|root,COG0649@2|Bacteria,1ZSV6@142182|Gemmatimonadetes 142182|Gemmatimonadetes C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient - - 1.6.5.3 ko:K00333 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_49kDa k59_133166_1 316058.RPB_4705 1.97e-35 134.0 COG0318@1|root,COG0318@2|Bacteria,1MWF2@1224|Proteobacteria,2TU4I@28211|Alphaproteobacteria,3JR3C@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria IQ AMP-binding enzyme C-terminal domain - - 6.2.1.48 ko:K02182 - - - - ko00000,ko01000 - - - AMP-binding,AMP-binding_C k59_133166_2 1122137.AQXF01000007_gene3475 3.55e-36 123.0 COG3750@1|root,COG3750@2|Bacteria,1N77J@1224|Proteobacteria,2UFX6@28211|Alphaproteobacteria 28211|Alphaproteobacteria D Belongs to the UPF0335 family - - - - - - - - - - - - DUF2312 k59_415197_2 1122137.AQXF01000001_gene2986 3.28e-60 199.0 COG2271@1|root,COG2271@2|Bacteria,1MWYR@1224|Proteobacteria,2U1SE@28211|Alphaproteobacteria 28211|Alphaproteobacteria G Major facilitator Superfamily - - - - - - - - - - - - MFS_1 k59_1376526_1 269799.Gmet_1368 1.48e-10 62.0 COG0586@1|root,COG0586@2|Bacteria,1NBBA@1224|Proteobacteria,42MFR@68525|delta/epsilon subdivisions,2WR9B@28221|Deltaproteobacteria 28221|Deltaproteobacteria S SNARE associated Golgi protein - - - - - - - - - - - - SNARE_assoc k59_471709_1 443152.MDG893_04372 2.46e-81 256.0 COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,1RMBQ@1236|Gammaproteobacteria,465NN@72275|Alteromonadaceae 1236|Gammaproteobacteria C belongs to the aldehyde dehydrogenase family aldB - 1.2.1.3 ko:K00128,ko:K00138 ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130 M00135 R00264,R00631,R00710,R00711,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146 RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_20272_1 330214.NIDE0631 8.1e-101 304.0 COG4313@1|root,COG4313@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_1262398_1 1448139.AI20_07910 2.68e-44 158.0 COG0402@1|root,COG0402@2|Bacteria,1MUPT@1224|Proteobacteria,1SYCI@1236|Gammaproteobacteria,1Y5B7@135624|Aeromonadales 135624|Aeromonadales F Amidohydrolase family - - 3.5.4.3 ko:K01487 ko00230,ko01100,map00230,map01100 - R01676 RC00204 ko00000,ko00001,ko01000 - - - Amidohydro_1 k59_868414_1 159087.Daro_3885 1.79e-06 48.9 COG0345@1|root,COG0345@2|Bacteria,1R5J1@1224|Proteobacteria,2VJD1@28216|Betaproteobacteria,2KUUS@206389|Rhodocyclales 206389|Rhodocyclales E Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline proC - 1.5.1.2 ko:K00286 ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230 M00015 R01248,R01251,R03291,R03293 RC00054,RC00083 ko00000,ko00001,ko00002,ko01000 - - - F420_oxidored,P5CR_dimer k59_868414_2 748247.AZKH_3848 6.45e-76 235.0 COG0325@1|root,COG0325@2|Bacteria,1MWN7@1224|Proteobacteria,2VHNY@28216|Betaproteobacteria,2KU9T@206389|Rhodocyclales 206389|Rhodocyclales S Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis - - - ko:K06997 - - - - ko00000 - - - Ala_racemase_N k59_1601982_2 1502724.FF80_01682 9.81e-14 78.2 COG0728@1|root,COG0728@2|Bacteria,1MUH0@1224|Proteobacteria,2TS44@28211|Alphaproteobacteria,3N6AR@45401|Hyphomicrobiaceae 28211|Alphaproteobacteria S Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane murJ - - ko:K03980 - - - - ko00000,ko01011,ko02000 2.A.66.4 - - MVIN k59_1545817_1 436308.Nmar_0845 3.65e-16 76.3 arCOG08709@1|root,arCOG08709@2157|Archaea,41T5B@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1149670_1 1380387.JADM01000001_gene189 1.02e-78 249.0 COG0493@1|root,COG0493@2|Bacteria,1MU2H@1224|Proteobacteria,1RMY7@1236|Gammaproteobacteria,1XIGF@135619|Oceanospirillales 135619|Oceanospirillales E glutamate synthase gltD - 1.4.1.13,1.4.1.14 ko:K00266 ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 - R00093,R00114,R00248 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - Fer4_20,Pyr_redox_2 k59_584844_2 269799.Gmet_1426 4.37e-74 256.0 COG2844@1|root,COG2844@2|Bacteria,1MV54@1224|Proteobacteria,42MN5@68525|delta/epsilon subdivisions,2WINN@28221|Deltaproteobacteria,43SYQ@69541|Desulfuromonadales 28221|Deltaproteobacteria H Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism glnD - 2.7.7.59 ko:K00990 ko02020,map02020 - - - ko00000,ko00001,ko01000 - - - ACT,DUF294,GlnD_UR_UTase,GlnE,HD,NTP_transf_2 k59_471724_1 330214.NIDE3419 2.59e-103 311.0 COG1232@1|root,COG1232@2|Bacteria 2|Bacteria H protoporphyrinogen oxidase activity - - 5.4.99.9 ko:K01854 ko00052,ko00520,map00052,map00520 - R00505,R09009 RC00317,RC02396 ko00000,ko00001,ko01000 - - - Amino_oxidase,Glyco_trans_1_4,NAD_binding_8 k59_1771156_1 1116472.MGMO_131c00050 1.5e-36 138.0 COG0376@1|root,COG0376@2|Bacteria,1MUBF@1224|Proteobacteria,1RNA5@1236|Gammaproteobacteria,1XG48@135618|Methylococcales 135618|Methylococcales P Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity katG - - - - - - - - - - - peroxidase k59_1771156_2 1336208.JADY01000008_gene2105 6.72e-10 56.2 COG2314@1|root,COG2314@2|Bacteria 2|Bacteria J TM2 domain - - - - - - - - - - - - TM2 k59_923878_1 436308.Nmar_1072 1.06e-140 412.0 COG0028@1|root,arCOG01998@2157|Archaea,41S63@651137|Thaumarchaeota 651137|Thaumarchaeota E TIGRFAM acetolactate synthase, large subunit, biosynthetic type - - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_1431966_1 1411685.U062_02196 3.29e-115 341.0 COG3288@1|root,COG3288@2|Bacteria,1MVXU@1224|Proteobacteria,1RN23@1236|Gammaproteobacteria 1236|Gammaproteobacteria C The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane pntA - 1.6.1.2 ko:K00324 ko00760,ko01100,map00760,map01100 - R00112 RC00001 ko00000,ko00001,ko01000 - - - AlaDh_PNT_C,AlaDh_PNT_N k59_698004_1 404589.Anae109_3753 4.65e-26 104.0 COG0262@1|root,COG0262@2|Bacteria,1R6X0@1224|Proteobacteria,42SP7@68525|delta/epsilon subdivisions,2WPDJ@28221|Deltaproteobacteria,2Z1J7@29|Myxococcales 28221|Deltaproteobacteria H RibD C-terminal domain - - - - - - - - - - - - RibD_C k59_1376562_1 316058.RPB_1394 2.46e-22 87.8 COG3237@1|root,COG3237@2|Bacteria,1N6X4@1224|Proteobacteria,2UF5Q@28211|Alphaproteobacteria,3K05I@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S CsbD-like - - - - - - - - - - - - CsbD k59_1545852_1 243233.MCA2540 1.57e-29 119.0 COG0058@1|root,COG0058@2|Bacteria,1MW4J@1224|Proteobacteria,1RN8P@1236|Gammaproteobacteria,1XDP7@135618|Methylococcales 135618|Methylococcales F Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties - - 2.4.1.1 ko:K00688 ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931 - R02111 - ko00000,ko00001,ko01000 - GT35 - Phosphorylase k59_979416_1 472759.Nhal_2104 2.57e-34 124.0 COG3339@1|root,COG3791@1|root,COG3339@2|Bacteria,COG3791@2|Bacteria,1MZR5@1224|Proteobacteria,1S912@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Protein of unknown function (DUF1232) - - - - - - - - - - - - DUF1232 k59_979416_2 714943.Mucpa_0384 4.15e-10 59.7 COG2062@1|root,COG2062@2|Bacteria,4NQFM@976|Bacteroidetes,1IST0@117747|Sphingobacteriia 976|Bacteroidetes T phosphohistidine phosphatase sixA - - ko:K08296 - - - - ko00000,ko01000 - - - His_Phos_1 k59_415255_1 1392490.JHZX01000001_gene1658 2.98e-95 291.0 COG2244@1|root,COG2244@2|Bacteria,4NDZ0@976|Bacteroidetes,1HWQF@117743|Flavobacteriia 976|Bacteroidetes S Polysaccharide biosynthesis protein cap - - - - - - - - - - - Polysacc_synt,Polysacc_synt_3,Polysacc_synt_C k59_1602031_1 1122137.AQXF01000003_gene2002 9.73e-96 294.0 COG1012@1|root,COG1012@2|Bacteria,1MV2I@1224|Proteobacteria,2TU8S@28211|Alphaproteobacteria 28211|Alphaproteobacteria C Catalyzes the NAD-dependent reduction of succinylglutamate semialdehyde into succinylglutamate astD - 1.2.1.71 ko:K06447 ko00330,ko01100,map00330,map01100 - R05049 RC00080 ko00000,ko00001,ko01000 - - - Aldedh k59_527619_1 316275.VSAL_I1813 5.55e-37 139.0 COG1823@1|root,COG1823@2|Bacteria,1R3F8@1224|Proteobacteria,1RMHV@1236|Gammaproteobacteria,1XUK9@135623|Vibrionales 135623|Vibrionales U Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family - - - ko:K06956 - - - - ko00000 - - - SDF k59_133234_1 436308.Nmar_0261 3.13e-112 326.0 COG0479@1|root,arCOG00962@2157|Archaea,41SAW@651137|Thaumarchaeota 651137|Thaumarchaeota C TIGRFAM succinate dehydrogenase and fumarate reductase iron-sulfur protein - - 1.3.5.1,1.3.5.4 ko:K00240 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00149,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 - - - Fer2_3,Fer4_8 k59_1376576_1 1122194.AUHU01000009_gene3165 2.33e-59 203.0 COG1200@1|root,COG1200@2|Bacteria,1MWN2@1224|Proteobacteria,1RMMQ@1236|Gammaproteobacteria,46544@72275|Alteromonadaceae 1236|Gammaproteobacteria L Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) recG GO:0003674,GO:0003678,GO:0003724,GO:0003824,GO:0004003,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006807,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0008186,GO:0009314,GO:0009379,GO:0009628,GO:0009987,GO:0010501,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0032991,GO:0033202,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0051276,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:0140098,GO:1901360,GO:1902494 3.6.4.12 ko:K03655 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,Helicase_C,RecG_wedge k59_1319657_1 313603.FB2170_09671 8.2e-138 400.0 COG1883@1|root,COG1883@2|Bacteria,4NH3V@976|Bacteroidetes,1I0X4@117743|Flavobacteriia 976|Bacteroidetes C Na+-transporting oxaloacetate decarboxylase beta subunit oadB - 4.1.1.3 ko:K01572 ko00620,ko01100,map00620,map01100 - R00217 RC00040 ko00000,ko00001,ko01000,ko02000 3.B.1.1.1 - - OAD_beta k59_190900_1 1235790.C805_02006 2.52e-06 49.7 COG1360@1|root,COG1360@2|Bacteria,1V8KE@1239|Firmicutes,24GQQ@186801|Clostridia,25WC4@186806|Eubacteriaceae 186801|Clostridia N OmpA family motB - - ko:K02557 ko02030,ko02040,map02030,map02040 - - - ko00000,ko00001,ko02000,ko02035 1.A.30.1 - - MotB_plug,OmpA k59_1320614_1 690597.JH730935_gene3309 5.08e-41 147.0 COG2951@1|root,COG2951@2|Bacteria,1MUZ3@1224|Proteobacteria,1RMQ6@1236|Gammaproteobacteria,1YPQY@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria M Lytic murein transglycosylase B mltB - - ko:K08305 - - - - ko00000,ko01000,ko01011 - GH103 - SLT_2 k59_1039546_1 1121943.KB899994_gene904 6.43e-11 71.6 COG2133@1|root,COG2931@1|root,COG3209@1|root,COG3291@1|root,COG3401@1|root,COG4733@1|root,COG4870@1|root,COG5276@1|root,COG2133@2|Bacteria,COG2931@2|Bacteria,COG3209@2|Bacteria,COG3291@2|Bacteria,COG3401@2|Bacteria,COG4733@2|Bacteria,COG4870@2|Bacteria,COG5276@2|Bacteria,1MU7T@1224|Proteobacteria,1S1HJ@1236|Gammaproteobacteria 1236|Gammaproteobacteria Q COG2931, RTX toxins and related Ca2 -binding proteins - - - - - - - - - - - - Cadherin,Cadherin_3,DUF4214,DUF4347,He_PIG,HemolysinCabind,PATR,VCBS k59_586191_1 861299.J421_2550 5.87e-81 250.0 COG0266@1|root,COG0266@2|Bacteria,1ZUR3@142182|Gemmatimonadetes 142182|Gemmatimonadetes L Formamidopyrimidine-DNA glycosylase N-terminal domain - - 3.2.2.23,4.2.99.18 ko:K10563 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - Fapy_DNA_glyco,H2TH,zf-FPG_IleRS k59_699374_1 395961.Cyan7425_3279 1.13e-21 102.0 COG5002@1|root,COG5002@2|Bacteria,1GHEK@1117|Cyanobacteria 1117|Cyanobacteria T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - CBS,GAF,HATPase_c,HisKA,Hpt,PAS,PAS_3,PAS_4,PAS_9,Response_reg,dCache_1 k59_1263342_2 1565129.JSFF01000001_gene947 2.11e-10 60.1 COG0330@1|root,COG0330@2|Bacteria,1PRSV@1224|Proteobacteria,1TK9U@1236|Gammaproteobacteria,2QACD@267890|Shewanellaceae 1236|Gammaproteobacteria O SPFH domain / Band 7 family - - - - - - - - - - - - Band_7 k59_79046_1 158500.BV97_02264 3.36e-16 77.8 COG1391@1|root,COG1391@2|Bacteria,1MU4I@1224|Proteobacteria,2TRY7@28211|Alphaproteobacteria,2K1YP@204457|Sphingomonadales 204457|Sphingomonadales H Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell glnE - 2.7.7.42,2.7.7.89 ko:K00982 - - - - ko00000,ko01000 - - - GlnD_UR_UTase,GlnE k59_79046_2 702113.PP1Y_AT1900 6.52e-79 236.0 COG1225@1|root,COG1225@2|Bacteria,1RD4R@1224|Proteobacteria,2U6Z9@28211|Alphaproteobacteria,2K4IB@204457|Sphingomonadales 204457|Sphingomonadales O Alkyl hydroperoxide reductase bcp - 1.11.1.15 ko:K03564 - - - - ko00000,ko01000 - - - AhpC-TSA k59_304664_1 713587.THITH_11265 9.2e-113 352.0 COG3280@1|root,COG3280@2|Bacteria 2|Bacteria G synthase treY GO:0000272,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0005984,GO:0005991,GO:0005992,GO:0006073,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009251,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016052,GO:0016853,GO:0016866,GO:0030978,GO:0030980,GO:0034637,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044247,GO:0044248,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044275,GO:0044424,GO:0044444,GO:0044464,GO:0046351,GO:0047470,GO:0071704,GO:1901575,GO:1901576 2.4.1.25,5.4.99.15 ko:K00705,ko:K06044 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R01824,R05196,R09995 RC00049 ko00000,ko00001,ko00002,ko01000 - GH13,GH77 - Alpha-amylase,Glyco_hydro_77 k59_755172_1 323848.Nmul_A0073 6.41e-72 221.0 COG3448@1|root,COG3448@2|Bacteria,1PW0P@1224|Proteobacteria,2WBMR@28216|Betaproteobacteria,373ER@32003|Nitrosomonadales 28216|Betaproteobacteria T HPP family - - - - - - - - - - - - HPP k59_1377953_1 314270.RB2083_945 1.56e-24 107.0 COG0591@1|root,COG0642@1|root,COG0591@2|Bacteria,COG2205@2|Bacteria,1MUY7@1224|Proteobacteria,2TR1M@28211|Alphaproteobacteria,3ZGQZ@58840|unclassified Rhodobacteraceae 28211|Alphaproteobacteria T Histidine kinase-, DNA gyrase B-, and HSP90-like resE - - - - - - - - - - - HATPase_c,HisKA,PAS_7,Response_reg,SSF k59_361286_1 335543.Sfum_0043 6.97e-98 312.0 COG0542@1|root,COG0542@2|Bacteria,1MV8B@1224|Proteobacteria,42M2T@68525|delta/epsilon subdivisions,2WJ2W@28221|Deltaproteobacteria,2MQYS@213462|Syntrophobacterales 28221|Deltaproteobacteria O C-terminal, D2-small domain, of ClpB protein clpA - - ko:K03694 - - - - ko00000,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N k59_361286_2 941449.dsx2_1852 1.02e-13 66.2 COG2127@1|root,COG2127@2|Bacteria,1MZU8@1224|Proteobacteria,42TN3@68525|delta/epsilon subdivisions,2WQ23@28221|Deltaproteobacteria,2MCM5@213115|Desulfovibrionales 28221|Deltaproteobacteria S Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation clpS - - ko:K06891 - - - - ko00000 - - - ClpS k59_1039583_1 1229909.NSED_08925 2.66e-82 261.0 arCOG08793@1|root,arCOG08812@1|root,arCOG08793@2157|Archaea,arCOG08812@2157|Archaea,41SXB@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_586221_1 1396418.BATQ01000008_gene1509 1.3e-37 133.0 COG1335@1|root,COG1335@2|Bacteria,46WYG@74201|Verrucomicrobia 74201|Verrucomicrobia Q Isochorismatase family - - - - - - - - - - - - Isochorismatase k59_1716267_1 566466.NOR53_1524 5.28e-37 135.0 COG0830@1|root,COG0830@2|Bacteria,1MW8Q@1224|Proteobacteria,1SWJT@1236|Gammaproteobacteria,1J9CY@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O Required for maturation of urease via the functional incorporation of the urease nickel metallocenter ureF - - - - - - - - - - - UreF k59_1094266_1 13689.BV96_00510 3.18e-132 386.0 COG0404@1|root,COG0404@2|Bacteria,1MWZS@1224|Proteobacteria,2TSVD@28211|Alphaproteobacteria,2K1VS@204457|Sphingomonadales 204457|Sphingomonadales E Aminomethyltransferase folate-binding domain - - - ko:K15064 ko00627,ko01120,map00627,map01120 - R09270 RC00113,RC00392 ko00000,ko00001,ko01000 - - - GCV_T,GCV_T_C k59_1547339_2 555793.WSK_0954 1.72e-84 258.0 COG0053@1|root,COG0053@2|Bacteria,1MVH8@1224|Proteobacteria,2TVQV@28211|Alphaproteobacteria,2JZZM@204457|Sphingomonadales 204457|Sphingomonadales P cation diffusion facilitator - - - - - - - - - - - - Cation_efflux,ZT_dimer k59_21733_1 1123279.ATUS01000001_gene1540 2.04e-09 60.1 COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,1RMQ4@1236|Gammaproteobacteria,1J5JW@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria IQ COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II - - - ko:K00666 - - - - ko00000,ko01000,ko01004 - - - AMP-binding,AMP-binding_C k59_21733_2 298655.KI912266_gene4773 9.25e-48 157.0 COG1545@1|root,COG1545@2|Bacteria 2|Bacteria I DUF35 OB-fold domain, acyl-CoA-associated - - - ko:K07068 - - - - ko00000 - - - DUF35_N,OB_aCoA_assoc k59_361311_1 643562.Daes_0004 1.4e-37 139.0 COG2870@1|root,COG2870@2|Bacteria,1MV3Z@1224|Proteobacteria,42MBC@68525|delta/epsilon subdivisions,2WIKU@28221|Deltaproteobacteria,2M9B9@213115|Desulfovibrionales 28221|Deltaproteobacteria M Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose hldE GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0006629,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0008713,GO:0008920,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016301,GO:0016310,GO:0016740,GO:0016757,GO:0016772,GO:0019200,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0046401,GO:0046835,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 2.7.1.167,2.7.7.70 ko:K03272 ko00540,ko01100,map00540,map01100 M00064 R05644,R05646 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000,ko01005 - - iAF987.Gmet_0922 CTP_transf_like,PfkB k59_361311_2 1121028.ARQE01000003_gene611 1.62e-80 254.0 COG0451@1|root,COG0451@2|Bacteria,1MVI8@1224|Proteobacteria,2TT7Q@28211|Alphaproteobacteria 28211|Alphaproteobacteria M NAD-dependent epimerase dehydratase - - 4.1.1.35,5.1.3.10,5.1.3.2,5.1.3.25 ko:K01784,ko:K08678,ko:K12454,ko:K17947 ko00052,ko00520,ko00523,ko01100,ko01130,map00052,map00520,map00523,map01100,map01130 M00361,M00362,M00632 R00291,R01384,R02984,R04266,R10279 RC00289,RC00508,RC00528 ko00000,ko00001,ko00002,ko01000 - - - Epimerase,GDP_Man_Dehyd k59_1771993_1 1713.JOFV01000006_gene2800 3.8e-08 57.8 COG0392@1|root,COG0392@2|Bacteria,2GMAV@201174|Actinobacteria,4F0KN@85016|Cellulomonadaceae 201174|Actinobacteria S Lysylphosphatidylglycerol synthase TM region - - - ko:K07027 - - - - ko00000,ko02000 4.D.2 - - LPG_synthase_TM k59_1771993_2 1043493.BBLU01000004_gene2703 1.7e-12 68.9 COG0628@1|root,COG0628@2|Bacteria,2GN4Y@201174|Actinobacteria 201174|Actinobacteria S permease - - - - - - - - - - - - AI-2E_transport k59_1377984_1 247634.GPB2148_821 5.07e-99 304.0 COG1012@1|root,COG1012@2|Bacteria,1MY4N@1224|Proteobacteria,1RR7Y@1236|Gammaproteobacteria,1J8SW@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Aldehyde dehydrogenase family paaN - - - - - - - - - - - Aldedh k59_1377984_2 247634.GPB2148_873 8.8e-45 157.0 COG3670@1|root,COG3670@2|Bacteria,1MY1X@1224|Proteobacteria,1RRE0@1236|Gammaproteobacteria,1J5JG@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C and related enzymes - - - ko:K11159 - - - - ko00000 - - - RPE65 k59_924966_1 1121921.KB898706_gene2997 3.92e-85 272.0 COG5265@1|root,COG5265@2|Bacteria,1NSKS@1224|Proteobacteria,1T1W9@1236|Gammaproteobacteria,2PMM7@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria V ABC transporter transmembrane region atmA - - ko:K06147 - - - - ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran k59_812239_1 1323361.JPOC01000021_gene2742 2.72e-25 109.0 COG2072@1|root,COG2072@2|Bacteria,2GJEA@201174|Actinobacteria,4FV0T@85025|Nocardiaceae 201174|Actinobacteria P L-lysine 6-monooxygenase (NADPH-requiring) - - 1.14.13.84 ko:K14520 ko00363,ko01100,ko01120,map00363,map01100,map01120 - R06892 RC01644 ko00000,ko00001,ko01000 - - - FMO-like,K_oxygenase,Pyr_redox_2,Pyr_redox_3 k59_361317_1 1122194.AUHU01000007_gene261 5.66e-40 145.0 COG0742@1|root,COG0742@2|Bacteria,1MX8Z@1224|Proteobacteria,1RMIB@1236|Gammaproteobacteria,466ZU@72275|Alteromonadaceae 1236|Gammaproteobacteria J Specifically methylates the guanosine in position 1516 of 16S rRNA rsmJ GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0008990,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036308,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.242 ko:K15984 - - - - ko00000,ko01000,ko03009 - - - SAM_MT k59_1320688_1 1165096.ARWF01000001_gene1384 1.36e-35 133.0 COG1652@1|root,COG1652@2|Bacteria,1MUBV@1224|Proteobacteria,2VIZJ@28216|Betaproteobacteria,2KMAE@206350|Nitrosomonadales 206350|Nitrosomonadales S Lysin motif - - - - - - - - - - - - LysM k59_79103_1 1221522.B723_15550 7.2e-28 112.0 COG0687@1|root,COG0687@2|Bacteria,1MUYW@1224|Proteobacteria,1RM7W@1236|Gammaproteobacteria 1236|Gammaproteobacteria P Required for the activity of the bacterial periplasmic transport system of putrescine potF - - ko:K11073 ko02010,map02010 M00300 - - ko00000,ko00001,ko00002,ko02000 3.A.1.11.2 - - SBP_bac_8 k59_79103_2 1122135.KB893134_gene3128 1.44e-44 155.0 COG1960@1|root,COG1960@2|Bacteria,1MUTN@1224|Proteobacteria,2U38F@28211|Alphaproteobacteria 28211|Alphaproteobacteria I Acyl-CoA dehydrogenase, C-terminal domain - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_1603498_1 316407.85676108 1.32e-44 145.0 COG1445@1|root,COG1445@2|Bacteria,1RICG@1224|Proteobacteria,1S65D@1236|Gammaproteobacteria,3XPRU@561|Escherichia 1236|Gammaproteobacteria G The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane frwD GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0008643,GO:0009401,GO:0015144,GO:0016020,GO:0016740,GO:0016772,GO:0016773,GO:0022804,GO:0022857,GO:0034219,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0090563,GO:0090582 - ko:K11202 - M00306 - - ko00000,ko00002,ko01000,ko02000 4.A.2.1 - - PTS_IIB k59_1603498_2 316407.85676109 6.76e-76 233.0 COG1180@1|root,COG1180@2|Bacteria,1PD9E@1224|Proteobacteria,1RQG5@1236|Gammaproteobacteria,3XN6N@561|Escherichia 1236|Gammaproteobacteria O Activation of pyruvate formate-lyase 2 under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine pflC - 1.97.1.4 ko:K04069 - - R04710 - ko00000,ko01000 - - e_coli_core.b3952,iAF1260.b3952,iAPECO1_1312.APECO1_2515,iBWG_1329.BWG_3620,iECDH10B_1368.ECDH10B_4140,iECDH1ME8569_1439.ECDH1ME8569_3820,iEcDH1_1363.EcDH1_4034,iJO1366.b3952,iJR904.b3952,iLF82_1304.LF82_1623,iNRG857_1313.NRG857_19745,iY75_1357.Y75_RS17295 Fer4_12,Radical_SAM k59_1263387_2 118161.KB235922_gene2280 1.05e-49 163.0 COG0225@1|root,COG0225@2|Bacteria,1G1QF@1117|Cyanobacteria,3VHR0@52604|Pleurocapsales 1117|Cyanobacteria O Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine msrA - 1.8.4.11 ko:K07304 - - - - ko00000,ko01000 - - - PMSR k59_1547377_1 1268068.PG5_40120 1.17e-89 272.0 COG1995@1|root,COG1995@2|Bacteria,1MX5W@1224|Proteobacteria,1RNZV@1236|Gammaproteobacteria 1236|Gammaproteobacteria H Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) pdxA GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006081,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008614,GO:0008615,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0034641,GO:0036094,GO:0042364,GO:0042802,GO:0042816,GO:0042819,GO:0042822,GO:0042823,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046184,GO:0046483,GO:0046872,GO:0046914,GO:0048037,GO:0050570,GO:0050662,GO:0051186,GO:0051188,GO:0051287,GO:0055114,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 1.1.1.262 ko:K00097 ko00750,ko01100,map00750,map01100 M00124 R05681,R05837,R07406 RC00089,RC00675,RC01475 ko00000,ko00001,ko00002,ko01000 - - iECO111_1330.ECO111_0056 PdxA k59_869897_1 387093.SUN_1413 8.41e-160 461.0 COG3119@1|root,COG3119@2|Bacteria,1MV92@1224|Proteobacteria,42PRE@68525|delta/epsilon subdivisions 1224|Proteobacteria P PFAM sulfatase atsA - 3.1.6.1 ko:K01130 ko00140,ko00600,map00140,map00600 - R03980,R04856 RC00128,RC00231 ko00000,ko00001,ko01000 - - - Sulfatase,Sulfatase_C k59_642373_1 326442.PSHAa0438 1.19e-46 171.0 COG4247@1|root,COG4247@2|Bacteria,1MVTA@1224|Proteobacteria,1RQXH@1236|Gammaproteobacteria,2PZWH@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria I Phytase phy - 3.1.3.8 ko:K01083 ko00562,map00562 - R03371 RC00078 ko00000,ko00001,ko01000 - - - Phytase k59_372286_2 1096930.L284_20605 2.45e-22 96.7 COG2200@1|root,COG4252@1|root,COG2200@2|Bacteria,COG4252@2|Bacteria,1N299@1224|Proteobacteria,2U5C8@28211|Alphaproteobacteria,2K2WP@204457|Sphingomonadales 204457|Sphingomonadales T Putative diguanylate phosphodiesterase - - - - - - - - - - - - CHASE2,EAL k59_1558990_1 316407.85675652 2.22e-111 339.0 COG0204@1|root,COG0318@1|root,COG0204@2|Bacteria,COG0318@2|Bacteria,1MWDY@1224|Proteobacteria,1RRXF@1236|Gammaproteobacteria,3XPGR@561|Escherichia 1236|Gammaproteobacteria I Plays a role in lysophospholipid acylation. Transfers fatty acids to the 1-position via an enzyme-bound acyl-ACP intermediate in the presence of ATP and magnesium. Its physiological function is to regenerate phosphatidylethanolamine from 2-acyl-glycero-3-phosphoethanolamine (2-acyl-GPE) formed by transacylation reactions or degradation by phospholipase A1 aas GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006629,GO:0006631,GO:0006644,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008374,GO:0008610,GO:0008654,GO:0008779,GO:0008922,GO:0009058,GO:0009987,GO:0015645,GO:0016020,GO:0016021,GO:0016740,GO:0016746,GO:0016747,GO:0016874,GO:0016877,GO:0016878,GO:0019637,GO:0019752,GO:0031224,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044425,GO:0044464,GO:0071704,GO:0071944,GO:0090407,GO:1901576 2.3.1.40,6.2.1.20 ko:K05939 ko00071,ko00564,map00071,map00564 - R01406,R04864 RC00014,RC00039,RC00041 ko00000,ko00001,ko01000 - - iEC042_1314.EC042_3034 AMP-binding,AMP-binding_C,Acyltransferase k59_1218126_1 1088721.NSU_3324 4.02e-105 311.0 COG0668@1|root,COG0668@2|Bacteria,1QATN@1224|Proteobacteria,2UUYU@28211|Alphaproteobacteria 28211|Alphaproteobacteria M Mechanosensitive ion channel - - - - - - - - - - - - MS_channel k59_933999_2 436308.Nmar_0741 2.64e-27 99.8 arCOG08803@1|root,arCOG08803@2157|Archaea 2157|Archaea S zinc finger - - - - - - - - - - - - - k59_1560984_1 1096930.L284_01695 7.64e-68 228.0 COG3127@1|root,COG3127@2|Bacteria,1MU9R@1224|Proteobacteria,2TS8V@28211|Alphaproteobacteria,2K03T@204457|Sphingomonadales 204457|Sphingomonadales Q ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_1051298_1 330214.NIDE3387 1.25e-58 195.0 COG2204@1|root,COG2204@2|Bacteria 2|Bacteria T phosphorelay signal transduction system - - - - - - - - - - - - HTH_8,Response_reg,Sigma54_activat k59_1779801_1 983920.Y88_2751 2.83e-63 199.0 COG0680@1|root,COG0680@2|Bacteria,1RE1C@1224|Proteobacteria,2U2IN@28211|Alphaproteobacteria 28211|Alphaproteobacteria C hydrogenase expression formation protein hupD GO:0003674,GO:0003824,GO:0004175,GO:0006464,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009987,GO:0010467,GO:0016485,GO:0016787,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0051604,GO:0070011,GO:0071704,GO:0140096,GO:1901564 - ko:K03605 - - - - ko00000,ko01000,ko01002 - - - HycI k59_1162404_1 1267535.KB906767_gene3159 7.41e-147 457.0 COG1201@1|root,COG1201@2|Bacteria,3Y348@57723|Acidobacteria,2JIVQ@204432|Acidobacteriia 204432|Acidobacteriia L dead deah - - - ko:K03724 - - - - ko00000,ko01000,ko03400 - - - DEAD,DEAD_assoc,Helicase_C k59_481705_1 443152.MDG893_12640 2.54e-26 107.0 COG1364@1|root,COG1364@2|Bacteria,1MU0T@1224|Proteobacteria,1RNVF@1236|Gammaproteobacteria,464AB@72275|Alteromonadaceae 1236|Gammaproteobacteria E Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate argJ - 2.3.1.1,2.3.1.35 ko:K00620 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028 R00259,R02282 RC00004,RC00064 ko00000,ko00001,ko00002,ko01000 - - - ArgJ k59_882500_1 1137799.GZ78_01890 8.28e-94 285.0 COG0500@1|root,COG2226@2|Bacteria,1MVXN@1224|Proteobacteria,1RNTN@1236|Gammaproteobacteria,1XICS@135619|Oceanospirillales 135619|Oceanospirillales Q ( 3 oxidation state) methyltransferase - - 2.1.1.137 ko:K07755 - - - - ko00000,ko01000 - - - Methyltransf_31 k59_764051_1 1232410.KI421418_gene2189 3.74e-81 265.0 COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MU0R@1224|Proteobacteria,42NDJ@68525|delta/epsilon subdivisions,2WJSH@28221|Deltaproteobacteria,43S61@69541|Desulfuromonadales 28221|Deltaproteobacteria G Pyruvate phosphate dikinase, PEP/pyruvate binding domain ppdK - 2.7.9.1 ko:K01006 ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200 M00169,M00171,M00172,M00173 R00206 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - PEP-utilizers,PEP-utilizers_C,PPDK_N k59_1614825_1 675817.VDA_002600 8.56e-13 73.9 COG1766@1|root,COG1766@2|Bacteria,1MUQR@1224|Proteobacteria,1RN6T@1236|Gammaproteobacteria,1XTYM@135623|Vibrionales 135623|Vibrionales N The M ring may be actively involved in energy transduction fliF - - ko:K02409 ko02040,map02040 - - - ko00000,ko00001,ko02035,ko02044 3.A.6.2,3.A.6.3 - - YscJ_FliF,YscJ_FliF_C k59_1614825_2 1500893.JQNB01000001_gene59 2.38e-14 68.2 COG1677@1|root,COG1677@2|Bacteria,1N6RZ@1224|Proteobacteria,1SD52@1236|Gammaproteobacteria,1X7II@135614|Xanthomonadales 135614|Xanthomonadales N Flagellar hook-basal body complex protein FliE fliE - - ko:K02408 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - FliE k59_1272681_1 1469607.KK073768_gene2652 1.49e-31 125.0 COG0855@1|root,COG0855@2|Bacteria,1G1WA@1117|Cyanobacteria,1HIDJ@1161|Nostocales 1117|Cyanobacteria P Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) ppk - 2.7.4.1 ko:K00937 ko00190,ko03018,map00190,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - PP_kinase,PP_kinase_C,PP_kinase_N k59_712078_1 1121012.AUKX01000017_gene3054 1.96e-29 117.0 COG1409@1|root,COG1409@2|Bacteria,4NW6R@976|Bacteroidetes,1I81S@117743|Flavobacteriia,23H2U@178469|Arenibacter 976|Bacteroidetes S Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes - - - - - - - - - - - - Metallophos k59_1561017_1 882378.RBRH_00333 0.000299 50.1 COG0642@1|root,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,2VJI1@28216|Betaproteobacteria,1JZSA@119060|Burkholderiaceae 28216|Betaproteobacteria T catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR - - - - - - - - - - - - DUF4118,GerE,HATPase_c,HisKA,PAS,PAS_10,PAS_3,PAS_4,Response_reg k59_1329519_1 1384056.N787_12640 1.53e-58 205.0 COG1391@1|root,COG1391@2|Bacteria,1MU4I@1224|Proteobacteria,1RP9N@1236|Gammaproteobacteria,1X38Z@135614|Xanthomonadales 135614|Xanthomonadales H Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell glnE GO:0000820,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006521,GO:0008150,GO:0008882,GO:0010565,GO:0016740,GO:0016772,GO:0016779,GO:0019222,GO:0031323,GO:0033238,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0062012,GO:0065007,GO:0070566,GO:0080090 2.7.7.42,2.7.7.89 ko:K00982 - - - - ko00000,ko01000 - - - GlnD_UR_UTase,GlnE k59_598951_1 1121930.AQXG01000001_gene1099 3.21e-52 177.0 COG1171@1|root,COG1171@2|Bacteria,4NEY2@976|Bacteroidetes,1IUV5@117747|Sphingobacteriia 976|Bacteroidetes E Pyridoxal-phosphate dependent enzyme ilvA - 4.3.1.19 ko:K01754 ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230 M00570 R00220,R00996 RC00418,RC02600 ko00000,ko00001,ko00002,ko01000 - - - PALP k59_481727_1 1280948.HY36_16710 3.34e-41 157.0 COG2272@1|root,COG2272@2|Bacteria,1MVQZ@1224|Proteobacteria,2UPPD@28211|Alphaproteobacteria,43ZBQ@69657|Hyphomonadaceae 28211|Alphaproteobacteria I Belongs to the type-B carboxylesterase lipase family - - - - - - - - - - - - COesterase k59_481727_2 765952.PUV_00830 1.29e-25 105.0 COG0861@1|root,COG0861@2|Bacteria,2JGY6@204428|Chlamydiae 204428|Chlamydiae P Integral membrane protein TerC family - - - ko:K05794 - - - - ko00000 - - - TerC k59_34546_1 745411.B3C1_03040 6.95e-25 114.0 COG4772@1|root,COG4772@2|Bacteria,1MUIH@1224|Proteobacteria,1RQYX@1236|Gammaproteobacteria,1J7KI@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P TonB dependent receptor yncD - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_259469_1 1121033.AUCF01000044_gene4597 1.57e-22 102.0 COG0457@1|root,COG0457@2|Bacteria,1MUZK@1224|Proteobacteria,2TS0U@28211|Alphaproteobacteria,2JPRT@204441|Rhodospirillales 204441|Rhodospirillales M Tetratricopeptide repeat - - - - - - - - - - - - Glyco_transf_9,TPR_1,TPR_11,TPR_16,TPR_2,TPR_4,TPR_8 k59_201782_1 247634.GPB2148_2037 1.21e-20 91.7 COG1228@1|root,COG1228@2|Bacteria,1MVAF@1224|Proteobacteria,1RQRP@1236|Gammaproteobacteria,1J8WE@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria Q COG1228 Imidazolonepropionase and related amidohydrolases - - - - - - - - - - - - Amidohydro_1 k59_201782_2 313606.M23134_07903 2.74e-36 127.0 COG0346@1|root,COG0346@2|Bacteria,4NQ3F@976|Bacteroidetes,47VM6@768503|Cytophagia 976|Bacteroidetes E Glyoxalase-like domain - - - - - - - - - - - - Glyoxalase k59_822159_1 1120950.KB892747_gene3684 9.36e-18 86.3 COG0612@1|root,COG0612@2|Bacteria,2GJZ3@201174|Actinobacteria,4DNY1@85009|Propionibacteriales 201174|Actinobacteria S Insulinase (Peptidase family M16) pepR GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - - - - - - - - - - Peptidase_M16,Peptidase_M16_C k59_1219454_1 1317118.ATO8_21461 9.47e-86 263.0 COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,2TQTP@28211|Alphaproteobacteria,4KNPA@93682|Roseivivax 28211|Alphaproteobacteria L Transposase IS116/IS110/IS902 family - - - ko:K07486 - - - - ko00000 - - - DEDD_Tnp_IS110,Transposase_20 k59_1162453_2 566466.NOR53_3038 4.75e-21 95.9 28M5H@1|root,2ZAJ9@2|Bacteria,1RJY2@1224|Proteobacteria,1SM8E@1236|Gammaproteobacteria,1J7EK@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_374183_1 1535422.ND16A_0424 3.87e-101 308.0 COG2304@1|root,COG2304@2|Bacteria,1R8EZ@1224|Proteobacteria,1SG9K@1236|Gammaproteobacteria,2Q7R9@267889|Colwelliaceae 1236|Gammaproteobacteria S Peptidase M64 N-terminus - - - - - - - - - - - - M64_N,Peptidase_M64 k59_1442409_1 983548.Krodi_0600 4.28e-162 461.0 COG1960@1|root,COG1960@2|Bacteria,4NEHA@976|Bacteroidetes,1HWV4@117743|Flavobacteriia,37E80@326319|Dokdonia 976|Bacteroidetes C Acyl-CoA dehydrogenase, N-terminal domain acdA - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_1561062_2 1096930.L284_23205 4.66e-40 144.0 COG4799@1|root,COG4799@2|Bacteria,1MVAX@1224|Proteobacteria,2TRI1@28211|Alphaproteobacteria,2K0V7@204457|Sphingomonadales 204457|Sphingomonadales I acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) pccB - 2.1.3.15,6.4.1.3 ko:K01966 ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200 M00373,M00741 R01859 RC00097,RC00609 ko00000,ko00001,ko00002,ko01000 - - - Carboxyl_trans k59_1051350_1 1229909.NSED_00030 1.11e-116 361.0 COG1615@1|root,arCOG06128@2157|Archaea,41SCS@651137|Thaumarchaeota 651137|Thaumarchaeota S Uncharacterised protein family (UPF0182) - - - ko:K09118 - - - - ko00000 - - - UPF0182 k59_764090_1 309801.trd_1276 6.07e-80 256.0 COG1154@1|root,COG1154@2|Bacteria,2G68R@200795|Chloroflexi,27XH0@189775|Thermomicrobia 189775|Thermomicrobia F Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) dxs - 2.2.1.7 ko:K01662 ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130 M00096 R05636 RC00032 ko00000,ko00001,ko00002,ko01000 - - - DXP_synthase_N,Transket_pyr,Transketolase_C k59_34561_1 316407.85676342 4.64e-192 541.0 COG0593@1|root,COG0593@2|Bacteria,1MU5H@1224|Proteobacteria,1RNHP@1236|Gammaproteobacteria,3XNWU@561|Escherichia 1236|Gammaproteobacteria L it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids dnaA GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003688,GO:0003690,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006275,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010556,GO:0016020,GO:0017076,GO:0019219,GO:0019222,GO:0030554,GO:0031323,GO:0031326,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0035639,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0051052,GO:0051171,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0090304,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901363,GO:1901576,GO:1990837,GO:2000112 - ko:K02313 ko02020,ko04112,map02020,map04112 - - - ko00000,ko00001,ko03032,ko03036 - - - Bac_DnaA,Bac_DnaA_C,DnaA_N k59_822174_1 1088721.NSU_3752 1.05e-80 251.0 COG0491@1|root,COG0607@1|root,COG0491@2|Bacteria,COG0607@2|Bacteria,1MURA@1224|Proteobacteria,2TR1F@28211|Alphaproteobacteria,2K3NJ@204457|Sphingomonadales 204457|Sphingomonadales P COG0491 Zn-dependent hydrolases, including glyoxylases - - - - - - - - - - - - Lactamase_B,Rhodanese k59_1272717_1 1423780.LOT_0127 0.000112 45.4 COG0454@1|root,COG0456@2|Bacteria,1V22A@1239|Firmicutes,4ITA6@91061|Bacilli,3F7BU@33958|Lactobacillaceae 91061|Bacilli K Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_1 k59_481744_1 644283.Micau_1624 5.09e-14 81.6 COG0265@1|root,COG5164@1|root,COG0265@2|Bacteria,COG5164@2|Bacteria,2IJ6Q@201174|Actinobacteria,4DDWI@85008|Micromonosporales 201174|Actinobacteria O peptidase S1 and S6, chymotrypsin Hap hhoB - - ko:K08372 ko02020,map02020 - - - ko00000,ko00001,ko01000,ko01002 - - - Trypsin_2 k59_1390823_1 105559.Nwat_1197 3.26e-80 250.0 COG0075@1|root,COG0075@2|Bacteria,1MWHJ@1224|Proteobacteria,1RNNI@1236|Gammaproteobacteria,1WZI5@135613|Chromatiales 135613|Chromatiales H Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. PhnW subfamily phnW - 2.6.1.37 ko:K03430 ko00440,ko01100,ko01120,map00440,map01100,map01120 - R04152 RC00008,RC00062 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_5 k59_599001_1 1088721.NSU_2591 5.8e-66 204.0 COG0605@1|root,COG0605@2|Bacteria,1MVW2@1224|Proteobacteria,2TU3T@28211|Alphaproteobacteria,2K112@204457|Sphingomonadales 204457|Sphingomonadales P Destroys radicals which are normally produced within the cells and which are toxic to biological systems - - 1.15.1.1 ko:K04564 ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016 - - - ko00000,ko00001,ko01000 - - - Sod_Fe_C,Sod_Fe_N k59_882576_1 717774.Marme_2968 5.87e-62 198.0 COG0462@1|root,COG0462@2|Bacteria,1MW21@1224|Proteobacteria,1RMUC@1236|Gammaproteobacteria,1XI6V@135619|Oceanospirillales 135619|Oceanospirillales F Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) prs - 2.7.6.1 ko:K00948 ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230 M00005 R01049 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - Pribosyl_synth,Pribosyltran_N k59_1390829_1 192222.Cj1601 1.08e-44 155.0 COG0106@1|root,COG0106@2|Bacteria,1MW6S@1224|Proteobacteria,42NRX@68525|delta/epsilon subdivisions,2YMSK@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria E 1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase hisA - 5.3.1.16 ko:K01814 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04640 RC00945 ko00000,ko00001,ko00002,ko01000 - - - His_biosynth k59_1390829_2 1384056.N787_11670 8.16e-46 154.0 COG0118@1|root,COG0118@2|Bacteria,1MU4X@1224|Proteobacteria,1RRP3@1236|Gammaproteobacteria,1X5IB@135614|Xanthomonadales 135614|Xanthomonadales E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR hisH - - ko:K02501 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04558 RC00010,RC01190,RC01943 ko00000,ko00001,ko00002,ko01000 - - - GATase k59_1390831_1 1229909.NSED_06435 1.16e-07 52.0 COG2141@1|root,arCOG02410@2157|Archaea,41SBM@651137|Thaumarchaeota 651137|Thaumarchaeota C Luciferase-like monooxygenase - - - ko:K14728 - - - - ko00000,ko01000 - - - Bac_luciferase k59_1390831_2 1229909.NSED_06440 1.16e-151 430.0 COG1454@1|root,arCOG00984@2157|Archaea,41SFC@651137|Thaumarchaeota 651137|Thaumarchaeota C PFAM Iron-containing alcohol dehydrogenase - - - ko:K18602 ko00720,ko01120,map00720,map01120 - R09289 RC00087 ko00000,ko00001,ko01000 - - - Fe-ADH k59_599020_1 519989.ECTPHS_10611 3.76e-37 137.0 COG0789@1|root,COG0789@2|Bacteria,1R9SN@1224|Proteobacteria,1S967@1236|Gammaproteobacteria,1WYBA@135613|Chromatiales 135613|Chromatiales K helix_turn_helix, mercury resistance - - - ko:K22491 - - - - ko00000,ko03000 - - - MerR_1 k59_882593_1 1122194.AUHU01000001_gene3 2.89e-59 191.0 COG1349@1|root,COG1349@2|Bacteria,1QM4U@1224|Proteobacteria,1RNN2@1236|Gammaproteobacteria,465D2@72275|Alteromonadaceae 1236|Gammaproteobacteria K DeoR C terminal sensor domain ulaR GO:0003674,GO:0005488,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0019842,GO:0030246,GO:0031406,GO:0031418,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0048029,GO:0048037,GO:0050662,GO:0071704,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576 - ko:K03477 - - - - ko00000,ko03000 - - - DeoRC,HTH_DeoR k59_882593_2 436229.JOEH01000008_gene4313 6.07e-44 152.0 COG1028@1|root,COG1028@2|Bacteria,2GJ1F@201174|Actinobacteria,2NGIZ@228398|Streptacidiphilus 201174|Actinobacteria IQ KR domain - - - - - - - - - - - - adh_short k59_317643_1 436308.Nmar_0495 1.91e-92 282.0 COG0719@1|root,arCOG01715@2157|Archaea,41S5W@651137|Thaumarchaeota 651137|Thaumarchaeota O FeS assembly protein SufB - - - ko:K09014 - - - - ko00000 - - - UPF0051 k59_1103986_1 1122137.AQXF01000006_gene712 4.21e-57 180.0 COG5442@1|root,COG5442@2|Bacteria,1N3N6@1224|Proteobacteria,2UC0Z@28211|Alphaproteobacteria 28211|Alphaproteobacteria N Flagellar protein FlaF - - - ko:K06602 - - - - ko00000,ko02035 - - - FlaF k59_317644_1 1121946.AUAX01000009_gene4396 1.94e-18 82.8 COG2197@1|root,COG2197@2|Bacteria,2GJ46@201174|Actinobacteria,4D8HK@85008|Micromonosporales 201174|Actinobacteria T helix_turn_helix, Lux Regulon - - - - - - - - - - - - GerE,Response_reg k59_317644_2 1380347.JNII01000006_gene1824 1.41e-13 73.2 COG4585@1|root,COG4585@2|Bacteria,2HDZV@201174|Actinobacteria,4EX5G@85013|Frankiales 201174|Actinobacteria T Histidine kinase - - - - - - - - - - - - HATPase_c,HisKA_3 k59_882610_1 1122998.AUHZ01000010_gene1519 4.92e-12 65.5 COG0493@1|root,COG1144@1|root,COG0493@2|Bacteria,COG1144@2|Bacteria,2GJ0A@201174|Actinobacteria,4DU0U@85009|Propionibacteriales 201174|Actinobacteria C Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster preT - - - - - - - - - - - Fer4,Fer4_20,Pyr_redox_2,Pyr_redox_3 k59_882610_2 700598.Niako_1259 1.69e-71 240.0 COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1146@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1146@2|Bacteria,4NF4F@976|Bacteroidetes,1IPIS@117747|Sphingobacteriia 976|Bacteroidetes C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin nifJ - 1.2.7.1 ko:K03737 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00173,M00307 R01196,R10866 RC00004,RC02742 br01601,ko00000,ko00001,ko00002,ko01000 - - - EKR,Fer4_16,Fer4_7,PFOR_II,POR,POR_N,TPP_enzyme_C k59_822215_1 1379270.AUXF01000004_gene3139 3.33e-56 202.0 COG0612@1|root,COG0612@2|Bacteria,1ZT1M@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Insulinase (Peptidase family M16) - - - ko:K07263 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M16,Peptidase_M16_C k59_1779879_2 983544.Lacal_2091 1.69e-54 173.0 COG0764@1|root,COG0764@2|Bacteria,4NSGQ@976|Bacteroidetes,1I431@117743|Flavobacteriia 976|Bacteroidetes I dehydratase fabZ - 4.2.1.59 ko:K02372 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04428,R04535,R04537,R04544,R04568,R04954,R04965,R07764,R10117,R10121 RC00831,RC01095 ko00000,ko00001,ko00002,ko01000,ko01004 - - - FabA k59_1503946_1 1114964.L485_21320 7.44e-19 90.5 COG2211@1|root,COG2211@2|Bacteria,1MVUM@1224|Proteobacteria,2U1DI@28211|Alphaproteobacteria,2K2D8@204457|Sphingomonadales 204457|Sphingomonadales G MFS/sugar transport protein - - - - - - - - - - - - MFS_2 k59_651729_1 1163617.SCD_n02481 4.43e-55 182.0 COG1589@1|root,COG1589@2|Bacteria,1N0T7@1224|Proteobacteria,2VRMV@28216|Betaproteobacteria 28216|Betaproteobacteria D Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly ftsQ - - ko:K03589 ko04112,map04112 - - - ko00000,ko00001,ko03036 - - - FtsQ,POTRA_1 k59_599052_1 1122137.AQXF01000003_gene2094 2.51e-44 160.0 COG0823@1|root,COG0823@2|Bacteria,1MWYK@1224|Proteobacteria,2VGDT@28211|Alphaproteobacteria 28211|Alphaproteobacteria U WD40-like Beta Propeller Repeat - - - - - - - - - - - - PD40 k59_599052_2 1122137.AQXF01000003_gene2093 5.31e-34 131.0 COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,1MWGR@1224|Proteobacteria 1224|Proteobacteria EU COG1506 Dipeptidyl aminopeptidases acylaminoacyl-peptidases - - - - - - - - - - - - PD40,Peptidase_S9 k59_1051398_1 1219045.BV98_000193 1.2e-120 363.0 COG2960@1|root,COG2960@2|Bacteria,1R494@1224|Proteobacteria,2TTAS@28211|Alphaproteobacteria,2KE1K@204457|Sphingomonadales 204457|Sphingomonadales S Protein of unknown function (DUF1552) - - - - - - - - - - - - HXXSHH k59_1051398_2 521674.Plim_2937 9.2e-05 46.6 COG2204@1|root,COG2204@2|Bacteria,2IXYA@203682|Planctomycetes 203682|Planctomycetes T COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains - - - ko:K07712 ko02020,map02020 M00497 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_1219504_1 203122.Sde_0925 1.84e-70 238.0 COG0086@1|root,COG0086@2|Bacteria,1MU3M@1224|Proteobacteria,1RPYH@1236|Gammaproteobacteria,46403@72275|Alteromonadaceae 1236|Gammaproteobacteria K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoC GO:0000428,GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0030880,GO:0032774,GO:0032991,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234 2.7.7.6 ko:K03046 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5 k59_1503951_1 883081.HMPREF9698_00097 8.06e-05 44.7 COG1057@1|root,COG1057@2|Bacteria,1V3SK@1239|Firmicutes,4HGXK@91061|Bacilli,27G7J@186828|Carnobacteriaceae 91061|Bacilli H Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) nadD GO:0000309,GO:0003674,GO:0003824,GO:0004515,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0070566,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.7.7.18 ko:K00969 ko00760,ko01100,map00760,map01100 M00115 R00137,R03005 RC00002 ko00000,ko00001,ko00002,ko01000 - - - CTP_transf_like k59_1503951_2 95619.PM1_0204980 1.25e-82 260.0 COG1466@1|root,COG1466@2|Bacteria,1MWYT@1224|Proteobacteria,1RQRE@1236|Gammaproteobacteria 1236|Gammaproteobacteria L dna polymerase III delta subunit holA GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0032991,GO:0034641,GO:0034645,GO:0042575,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0090304,GO:1901360,GO:1901576,GO:1902494,GO:1990234 2.7.7.7 ko:K02340 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_delt_C,DNA_pol3_delta k59_651734_1 1192124.LIG30_1364 1.26e-65 215.0 COG0369@1|root,COG1151@2|Bacteria,1N88B@1224|Proteobacteria,2VNCJ@28216|Betaproteobacteria,1K2Y7@119060|Burkholderiaceae 28216|Betaproteobacteria C Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O hcp - 1.7.99.1 ko:K05601 ko00910,map00910 - R00143 RC02797 ko00000,ko00001,ko01000 - - - Prismane k59_651734_2 999419.HMPREF1077_03078 0.0007 41.6 COG1052@1|root,COG1052@2|Bacteria,4NF1R@976|Bacteroidetes,2FMNY@200643|Bacteroidia,22WSN@171551|Porphyromonadaceae 976|Bacteroidetes CH D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain ldhA - 1.1.1.28 ko:K03778 ko00620,ko01120,map00620,map01120 - R00704 RC00044 ko00000,ko00001,ko01000 - - - 2-Hacid_dh,2-Hacid_dh_C k59_481788_1 1118235.CAJH01000013_gene809 1.31e-35 126.0 COG4567@1|root,COG4567@2|Bacteria,1RD7J@1224|Proteobacteria,1S3PE@1236|Gammaproteobacteria,1X637@135614|Xanthomonadales 135614|Xanthomonadales T Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain regR - - ko:K15012 ko02020,map02020 M00523 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg k59_481788_2 1122185.N792_04740 4.34e-58 198.0 COG1629@1|root,COG4771@2|Bacteria,1MW7D@1224|Proteobacteria,1RNET@1236|Gammaproteobacteria,1X3EK@135614|Xanthomonadales 135614|Xanthomonadales P receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_426283_1 1121912.AUHD01000020_gene3383 4.87e-135 392.0 COG0626@1|root,COG0626@2|Bacteria,4PKE6@976|Bacteroidetes,1IJ8Q@117743|Flavobacteriia 976|Bacteroidetes E Catalyzes the formation of L-homocysteine from O- succinyl-L-homoserine (OSHS) and hydrogen sulfide - - 4.4.1.8 ko:K01760 ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230 M00017 R00782,R01286,R02408,R04941 RC00056,RC00069,RC00382,RC00488,RC00710,RC01245,RC02303 ko00000,ko00001,ko00002,ko01000 - - - Cys_Met_Meta_PP k59_1503964_1 1177181.T9A_00339 3e-07 53.5 COG0725@1|root,COG0725@2|Bacteria,1MVNA@1224|Proteobacteria,1RN71@1236|Gammaproteobacteria,1XJRJ@135619|Oceanospirillales 135619|Oceanospirillales P ABC transporter periplasmic modA - - ko:K02020 ko02010,map02010 M00189 - - ko00000,ko00001,ko00002,ko02000 3.A.1.8 - - SBP_bac_11 k59_1503964_2 1034943.BN1094_02094 6.61e-20 85.1 COG0454@1|root,COG0456@2|Bacteria,1N891@1224|Proteobacteria 1224|Proteobacteria K COG0454 Histone acetyltransferase HPA2 and related acetyltransferases - - - - - - - - - - - - Acetyltransf_1,Acetyltransf_10,Acetyltransf_7 k59_317679_1 1488328.JMCL01000057_gene1142 7.1e-144 421.0 COG3385@1|root,COG3385@2|Bacteria 2|Bacteria L transposase activity - - - - - - - - - - - - DDE_Tnp_1,Nterm_IS4 k59_764141_1 857087.Metme_0076 6.38e-47 154.0 COG3791@1|root,COG3791@2|Bacteria,1N0W7@1224|Proteobacteria,1SC8R@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Glutathione-dependent formaldehyde-activating enzyme - - - - - - - - - - - - GFA k59_201882_1 247633.GP2143_04028 6.05e-114 335.0 2BVW3@1|root,2Z7TB@2|Bacteria,1MY60@1224|Proteobacteria,1RNI9@1236|Gammaproteobacteria,1J5IV@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S 5'-nucleotidase ushA - 3.1.3.5 ko:K01081 ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110 - R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346 RC00017 ko00000,ko00001,ko01000 - - - 5-nucleotidase k59_1561166_1 477184.KYC_12198 3.12e-96 283.0 COG1335@1|root,COG1335@2|Bacteria,1RBT2@1224|Proteobacteria,2WFJT@28216|Betaproteobacteria 28216|Betaproteobacteria Q Isochorismatase family - - - - - - - - - - - - Isochorismatase k59_1561166_2 477184.KYC_12193 3.44e-16 77.8 COG1804@1|root,COG1804@2|Bacteria,1NSWZ@1224|Proteobacteria 1224|Proteobacteria C Dehydratase - - 2.8.3.15 ko:K07544 ko00623,ko01100,ko01120,ko01220,map00623,map01100,map01120,map01220 M00418 R05588 RC00014,RC00137 ko00000,ko00001,ko00002,ko01000 - - - CoA_transf_3 k59_1561167_1 1408445.JHXP01000020_gene1908 7.74e-39 144.0 COG0708@1|root,COG0708@2|Bacteria,1NHXD@1224|Proteobacteria,1T3UJ@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Endonuclease/Exonuclease/phosphatase family - - - - - - - - - - - - Exo_endo_phos k59_1518066_1 1042375.AFPL01000016_gene7 3.08e-32 122.0 COG1752@1|root,COG1752@2|Bacteria,1MUM9@1224|Proteobacteria,1RRA1@1236|Gammaproteobacteria,4641H@72275|Alteromonadaceae 1236|Gammaproteobacteria S esterase of the alpha-beta hydrolase superfamily rssA GO:0003674,GO:0003824,GO:0016787 - ko:K07001 - - - - ko00000 - - - Patatin k59_1518066_2 1122137.AQXF01000002_gene346 1.1e-194 544.0 COG1186@1|root,COG1186@2|Bacteria,1MUAW@1224|Proteobacteria,2TR9V@28211|Alphaproteobacteria 28211|Alphaproteobacteria J Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA prfB - - ko:K02836 - - - - ko00000,ko03012 - - - PCRF,RF-1 k59_1518066_3 1122137.AQXF01000002_gene347 7.2e-19 85.1 COG5009@1|root,COG5009@2|Bacteria,1MU5A@1224|Proteobacteria,2USBB@28211|Alphaproteobacteria 28211|Alphaproteobacteria M penicillin-binding protein mrcA - 2.4.1.129,3.4.16.4 ko:K05366 ko00550,ko01100,ko01501,map00550,map01100,map01501 - - - ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 - PCB_OB,Transgly,Transpeptidase k59_495095_1 644107.SL1157_0432 3.31e-68 218.0 COG2084@1|root,COG2084@2|Bacteria,1MUGU@1224|Proteobacteria,2TT50@28211|Alphaproteobacteria,4NAW8@97050|Ruegeria 28211|Alphaproteobacteria C hmm pf03446 MA20_25935 - 1.1.1.31,1.1.1.60 ko:K00020,ko:K00042 ko00280,ko00630,ko01100,map00280,map00630,map01100 - R01745,R01747,R05066 RC00099 ko00000,ko00001,ko01000 - - - NAD_binding_11,NAD_binding_2 k59_665998_1 448385.sce7469 1.45e-24 108.0 COG1858@1|root,COG3391@1|root,COG1858@2|Bacteria,COG3391@2|Bacteria,1R66T@1224|Proteobacteria 1224|Proteobacteria C amine dehydrogenase activity - - - - - - - - - - - - Lactonase k59_1793008_1 1229909.NSED_00615 7.65e-98 300.0 COG1001@1|root,arCOG00693@2157|Archaea,41SZH@651137|Thaumarchaeota 651137|Thaumarchaeota F Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family ade - 3.5.4.2 ko:K01486 ko00230,ko01100,map00230,map01100 - R01244 RC00477 ko00000,ko00001,ko01000 - - - Adenine_deam_C,Amidohydro_1 k59_48386_2 525897.Dbac_1791 1.47e-14 78.2 COG1559@1|root,COG1559@2|Bacteria,1MUQF@1224|Proteobacteria,42MPA@68525|delta/epsilon subdivisions,2WJ0Q@28221|Deltaproteobacteria,2M83W@213115|Desulfovibrionales 28221|Deltaproteobacteria S Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation mltG - - ko:K07082 - - - - ko00000 - - - YceG k59_48387_1 1379270.AUXF01000004_gene3082 1.65e-103 318.0 COG0187@1|root,COG0187@2|Bacteria,1ZSP9@142182|Gemmatimonadetes 142182|Gemmatimonadetes L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrB - 5.99.1.3 ko:K02470 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim k59_1628221_1 743836.AYNA01000004_gene1841 1.31e-47 162.0 COG3023@1|root,COG3023@2|Bacteria,1RDHU@1224|Proteobacteria,2VF4R@28211|Alphaproteobacteria 28211|Alphaproteobacteria V Ami_2 ampD - - - - - - - - - - - Amidase_2,SH3_3 k59_1405546_1 745014.OMB55_00024120 2.24e-48 170.0 COG0793@1|root,COG0793@2|Bacteria,1MU39@1224|Proteobacteria,1RMSR@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Belongs to the peptidase S41A family ctpA - 3.4.21.102 ko:K03797 - - - - ko00000,ko01000,ko01002 - - - PDZ_2,Peptidase_S41 k59_550720_1 309807.SRU_0696 7.84e-50 183.0 COG3127@1|root,COG3127@2|Bacteria,4NF16@976|Bacteroidetes,1FIZR@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes Q MacB-like periplasmic core domain - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_666011_1 305900.GV64_06660 2.01e-09 60.5 2CH72@1|root,32ZK4@2|Bacteria,1N8YD@1224|Proteobacteria,1SCY7@1236|Gammaproteobacteria,1XM5R@135619|Oceanospirillales 135619|Oceanospirillales S Protein of unknown function (DUF2878) - - - - - - - - - - - - DUF2878 k59_666011_2 1131730.BAVI_08241 5.46e-15 79.0 COG0318@1|root,COG0318@2|Bacteria,1TPSX@1239|Firmicutes,4HACS@91061|Bacilli,1ZB6H@1386|Bacillus 91061|Bacilli H Belongs to the ATP-dependent AMP-binding enzyme family. MenE subfamily menE - 6.2.1.26 ko:K01911 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116 R04030 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000 - - - AMP-binding,AMP-binding_C k59_1628236_2 1122137.AQXF01000005_gene1301 6.72e-163 471.0 COG1570@1|root,COG1570@2|Bacteria,1MUA4@1224|Proteobacteria,2TR1R@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides xseA - 3.1.11.6 ko:K03601 ko03430,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - Exonuc_VII_L,tRNA_anti_2 k59_1628240_1 196367.JNFG01000201_gene3024 6.83e-12 70.9 COG0523@1|root,COG0523@2|Bacteria,1R632@1224|Proteobacteria,2W97E@28216|Betaproteobacteria,1KDFP@119060|Burkholderiaceae 28216|Betaproteobacteria S Cobalamin synthesis protein cobW C-terminal domain - - - - - - - - - - - - CobW_C,cobW k59_1628242_1 1163617.SCD_n01322 4.66e-26 107.0 COG3156@1|root,COG3156@2|Bacteria,1RBNV@1224|Proteobacteria,2VS9P@28216|Betaproteobacteria 28216|Betaproteobacteria U general secretion pathway protein K gspK - - ko:K02460 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - T2SSK k59_495112_1 688245.CtCNB1_3605 9.39e-09 57.4 COG1380@1|root,COG1380@2|Bacteria,1PTJY@1224|Proteobacteria,2VXJQ@28216|Betaproteobacteria,4AF84@80864|Comamonadaceae 28216|Betaproteobacteria S PFAM LrgA family protein - - - - - - - - - - - - LrgA k59_331726_1 1229909.NSED_01005 2.13e-90 268.0 COG0586@1|root,arCOG03117@2157|Archaea,41SQ5@651137|Thaumarchaeota 651137|Thaumarchaeota S SNARE associated Golgi protein - - - - - - - - - - - - SNARE_assoc k59_331726_2 1229909.NSED_07240 3.95e-07 52.8 COG3794@1|root,arCOG02926@2157|Archaea 2157|Archaea C PFAM blue (type 1) copper domain protein - - - - - - - - - - - - Copper-bind,Cu-oxidase_2,Cu-oxidase_3,Cupredoxin_1 k59_836690_1 1041147.AUFB01000008_gene882 2.74e-20 96.3 COG0642@1|root,COG0745@1|root,COG2203@1|root,COG4191@1|root,COG0745@2|Bacteria,COG2203@2|Bacteria,COG2205@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TQQ9@28211|Alphaproteobacteria,4B880@82115|Rhizobiaceae 28211|Alphaproteobacteria T Histidine kinase - - - - - - - - - - - - CHASE3,GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg k59_1405578_1 1120983.KB894570_gene1244 7.89e-97 288.0 COG0034@1|root,COG0034@2|Bacteria,1MWHP@1224|Proteobacteria,2U06H@28211|Alphaproteobacteria,1JPSI@119043|Rhodobiaceae 28211|Alphaproteobacteria F Glutamine amidotransferase domain glxB - 2.1.1.21 ko:K22081 ko00680,ko01120,map00680,map01120 - R01586 RC00554 ko00000,ko00001,ko01000 - - - GATase_6 k59_1405578_2 1120983.KB894570_gene1245 9.55e-17 77.8 COG2218@1|root,COG2218@2|Bacteria,1MUUQ@1224|Proteobacteria,2TSRA@28211|Alphaproteobacteria,1JPZU@119043|Rhodobiaceae 28211|Alphaproteobacteria C GXGXG motif glxC - 2.1.1.21 ko:K22082 ko00680,ko01120,map00680,map01120 - R01586 RC00554 ko00000,ko00001,ko01000 - - - GXGXG k59_947963_1 187272.Mlg_2654 6.8e-62 208.0 COG0405@1|root,COG0405@2|Bacteria,1MUV6@1224|Proteobacteria,1RMIT@1236|Gammaproteobacteria,1WWYZ@135613|Chromatiales 135613|Chromatiales E PFAM Gamma-glutamyltranspeptidase - - 2.3.2.2,3.4.19.13 ko:K00681 ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100 - R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935 RC00064,RC00090,RC00096 ko00000,ko00001,ko01000,ko01002 - - - G_glu_transpept k59_1405587_1 1415779.JOMH01000001_gene101 2.99e-11 69.3 COG1020@1|root,COG1020@2|Bacteria,1N7HY@1224|Proteobacteria,1RQJX@1236|Gammaproteobacteria,1X3CA@135614|Xanthomonadales 135614|Xanthomonadales Q Protein of unknown function (DUF1298) - - - - - - - - - - - - DUF1298,WES_acyltransf k59_1793048_1 861299.J421_3741 2.83e-90 282.0 COG1217@1|root,COG1217@2|Bacteria,1ZT8A@142182|Gemmatimonadetes 142182|Gemmatimonadetes T Elongation factor G C-terminus - - - ko:K06207 - - - - ko00000 - - - EFG_C,GTP_EFTU,GTP_EFTU_D2 k59_388766_1 207559.Dde_1881 0.000418 44.3 2C4D9@1|root,337PW@2|Bacteria,1NE4W@1224|Proteobacteria,42QXQ@68525|delta/epsilon subdivisions,2WMPR@28221|Deltaproteobacteria,2MB2C@213115|Desulfovibrionales 28221|Deltaproteobacteria S Protein of unknown function (DUF1353) - - - - - - - - - - - - DUF1353 k59_388766_2 984262.SGRA_3155 0.000538 46.6 COG1864@1|root,COG1864@2|Bacteria,4NFYJ@976|Bacteroidetes 976|Bacteroidetes F DNA RNA non-specific endonuclease nucA - - ko:K01173 ko04210,map04210 - - - ko00000,ko00001,ko03029 - - - Endonuclease_NS k59_1405598_2 492774.JQMB01000012_gene475 2.75e-23 97.1 COG3917@1|root,COG3917@2|Bacteria,1MWB9@1224|Proteobacteria,2U07P@28211|Alphaproteobacteria,4BCUR@82115|Rhizobiaceae 28211|Alphaproteobacteria Q 2-hydroxychromene-2-carboxylate isomerase - - - - - - - - - - - - DSBA k59_48423_2 1122137.AQXF01000007_gene3518 1.69e-209 581.0 COG0039@1|root,COG0039@2|Bacteria,1MV57@1224|Proteobacteria,2TSV6@28211|Alphaproteobacteria 28211|Alphaproteobacteria C Catalyzes the reversible oxidation of malate to oxaloacetate mdh GO:0003674,GO:0003824,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016491,GO:0016614,GO:0016615,GO:0016616,GO:0016999,GO:0017144,GO:0019752,GO:0030060,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0055114,GO:0071704,GO:0072350 1.1.1.37 ko:K00024 ko00020,ko00270,ko00620,ko00630,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00270,map00620,map00630,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740 R00342,R07136 RC00031 ko00000,ko00001,ko00002,ko01000 - - - Ldh_1_C,Ldh_1_N k59_1117759_1 1229909.NSED_08955 1.04e-91 273.0 COG1121@1|root,arCOG00201@2157|Archaea,41S7E@651137|Thaumarchaeota 651137|Thaumarchaeota E PFAM ABC transporter - - - ko:K09817 ko02010,map02010 M00242 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.15.3,3.A.1.15.5 - - ABC_tran k59_836732_2 589865.DaAHT2_1352 3.86e-61 202.0 COG0568@1|root,COG0568@2|Bacteria,1MVWR@1224|Proteobacteria,42NRM@68525|delta/epsilon subdivisions,2WJ0S@28221|Deltaproteobacteria,2MHVP@213118|Desulfobacterales 28221|Deltaproteobacteria K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released rpoH - - ko:K03086,ko:K03089 - - - - ko00000,ko03021 - - - Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4 k59_1518120_1 1209989.TepiRe1_1991 4.64e-35 124.0 COG0054@1|root,COG0054@2|Bacteria,1V1DA@1239|Firmicutes,24FRS@186801|Clostridia,42G01@68295|Thermoanaerobacterales 186801|Clostridia H Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin ribH - 2.5.1.78 ko:K00794 ko00740,ko01100,ko01110,map00740,map01100,map01110 M00125 R04457 RC00960 ko00000,ko00001,ko00002,ko01000 - - - DMRL_synthase k59_1518120_2 395493.BegalDRAFT_1167 1.23e-12 68.9 COG0108@1|root,COG0108@2|Bacteria,1MU8P@1224|Proteobacteria,1RQ49@1236|Gammaproteobacteria,45ZV7@72273|Thiotrichales 72273|Thiotrichales H Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate ribB - 3.5.4.25,4.1.99.12 ko:K14652 ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110 M00125,M00840 R00425,R07281 RC00293,RC01792,RC01815,RC02504 ko00000,ko00001,ko00002,ko01000 - - - DHBP_synthase,GTP_cyclohydro2 k59_1117768_1 1216976.AX27061_5878 1.09e-27 105.0 COG2096@1|root,COG2096@2|Bacteria,1RDUF@1224|Proteobacteria,2VQ7P@28216|Betaproteobacteria,3T3U8@506|Alcaligenaceae 28216|Betaproteobacteria S Cobalamin adenosyltransferase yvqK GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005525,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009235,GO:0009236,GO:0009987,GO:0016043,GO:0016740,GO:0016765,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019003,GO:0019438,GO:0019538,GO:0022607,GO:0030091,GO:0030554,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032559,GO:0032561,GO:0033013,GO:0033014,GO:0034641,GO:0035639,GO:0036094,GO:0042364,GO:0043167,GO:0043168,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0051186,GO:0051188,GO:0051259,GO:0051260,GO:0065003,GO:0070206,GO:0070207,GO:0071704,GO:0071840,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.5.1.17 ko:K00798 ko00860,ko01100,map00860,map01100 M00122 R01492,R05220,R07268 RC00533 ko00000,ko00001,ko00002,ko01000 - - - Cob_adeno_trans k59_1117768_2 667632.KB890198_gene1207 4.51e-29 111.0 COG1595@1|root,COG1595@2|Bacteria,1N00E@1224|Proteobacteria,2VQNP@28216|Betaproteobacteria,1K7A5@119060|Burkholderiaceae 28216|Betaproteobacteria K Belongs to the sigma-70 factor family. ECF subfamily rpoE1 - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4,Sigma70_r4_2 k59_1003531_1 1370120.AUWR01000065_gene3535 1.1e-07 58.5 COG0645@1|root,COG2187@1|root,COG0645@2|Bacteria,COG2187@2|Bacteria,2GM3U@201174|Actinobacteria,23637@1762|Mycobacteriaceae 201174|Actinobacteria S AAA domain - GO:0003674,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0009987,GO:0030312,GO:0044464,GO:0044764,GO:0046812,GO:0051704,GO:0071944 - ko:K07028 - - - - ko00000 - - - AAA_33,APH k59_550765_1 247633.GP2143_09160 2.67e-68 223.0 COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,1RN0I@1236|Gammaproteobacteria,1J9RA@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria MU Outer membrane efflux protein cusC - - ko:K18139 ko01501,ko02024,map01501,map02024 M00642,M00643,M00647,M00718,M00768,M00822 - - ko00000,ko00001,ko00002,ko01504,ko02000 1.B.17,2.A.6.2 - - OEP k59_897189_2 1229909.NSED_05195 7.69e-36 124.0 COG4901@1|root,arCOG04327@2157|Archaea,41SUF@651137|Thaumarchaeota 651137|Thaumarchaeota J S25 ribosomal protein - - - ko:K02975 ko03010,map03010 M00177,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S25 k59_897189_3 436308.Nmar_0929 1.27e-14 67.0 arCOG05330@1|root,arCOG05330@2157|Archaea,41SUC@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1683576_1 158500.BV97_01846 1.07e-11 67.0 COG4773@1|root,COG4773@2|Bacteria,1QTXJ@1224|Proteobacteria,2UPEK@28211|Alphaproteobacteria,2KEF0@204457|Sphingomonadales 204457|Sphingomonadales P TonB dependent receptor - - - - - - - - - - - - Plug,TonB_dep_Rec k59_1683576_2 392499.Swit_3248 5.95e-54 180.0 COG0123@1|root,COG0123@2|Bacteria,1MU7P@1224|Proteobacteria,2TRRH@28211|Alphaproteobacteria,2K0SH@204457|Sphingomonadales 204457|Sphingomonadales BQ Histone deacetylase domain - - - - - - - - - - - - Hist_deacetyl k59_216073_1 512565.AMIS_55080 1.19e-11 70.9 COG3866@1|root,COG3866@2|Bacteria,2GJEJ@201174|Actinobacteria,4DA4Q@85008|Micromonosporales 201174|Actinobacteria G Pectate lyase pel - 4.2.2.2 ko:K01728 ko00040,ko02024,map00040,map02024 - R02361,R06240 RC00049,RC00705 ko00000,ko00001,ko01000 - - - Pec_lyase_C k59_1575536_1 1265313.HRUBRA_02662 7.39e-92 296.0 COG0458@1|root,COG0458@2|Bacteria,1MUDZ@1224|Proteobacteria,1RPIU@1236|Gammaproteobacteria 1236|Gammaproteobacteria F Carbamoyl-phosphate synthetase ammonia chain carB GO:0000050,GO:0000166,GO:0003674,GO:0003824,GO:0004087,GO:0004088,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005951,GO:0006082,GO:0006139,GO:0006206,GO:0006220,GO:0006221,GO:0006520,GO:0006525,GO:0006526,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016053,GO:0016597,GO:0016874,GO:0016879,GO:0016884,GO:0017076,GO:0018130,GO:0019438,GO:0019627,GO:0019637,GO:0019693,GO:0019752,GO:0019856,GO:0030554,GO:0031406,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046112,GO:0046390,GO:0046394,GO:0046483,GO:0046872,GO:0055086,GO:0071704,GO:0071941,GO:0072527,GO:0072528,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494 6.3.5.5 ko:K01955 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - iAF1260.b0033,iBWG_1329.BWG_0031,iECDH10B_1368.ECDH10B_0034,iECDH1ME8569_1439.ECDH1ME8569_0031,iECUMN_1333.ECUMN_0034,iEcDH1_1363.EcDH1_3566,iJN746.PP_4723,iJO1366.b0033,iJR904.b0033,iPC815.YPO0482,iY75_1357.Y75_RS00170,iYL1228.KPN_00041 CPSase_L_D2,CPSase_L_D3,MGS k59_777353_1 397288.C806_04444 6.36e-17 80.5 COG0164@1|root,COG0164@2|Bacteria,1V1D6@1239|Firmicutes,248IT@186801|Clostridia,27JFF@186928|unclassified Lachnospiraceae 186801|Clostridia L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids rnhB - 3.1.26.4 ko:K03470 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - RNase_HII k59_777353_2 1267533.KB906740_gene361 7.55e-16 75.5 COG0424@1|root,COG0424@2|Bacteria,3Y4ZU@57723|Acidobacteria,2JJH8@204432|Acidobacteriia 204432|Acidobacteriia D Maf-like protein - - - ko:K06287 - - - - ko00000 - - - Maf k59_1232434_1 247633.GP2143_08604 4.35e-69 236.0 COG1643@1|root,COG1643@2|Bacteria,1MUEQ@1224|Proteobacteria,1RMU1@1236|Gammaproteobacteria,1J5AR@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L COG1643 HrpA-like helicases hrpA GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0006139,GO:0006396,GO:0006397,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0034641,GO:0042623,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0070035,GO:0071704,GO:0090304,GO:0140098,GO:1901360 3.6.4.13 ko:K03578 - - - - ko00000,ko01000 - - - DEAD,DUF3418,HA2,Helicase_C,OB_NTP_bind k59_550782_1 945550.VISI1226_02562 4.2e-17 82.8 COG0668@1|root,COG0668@2|Bacteria,1N596@1224|Proteobacteria,1RQZP@1236|Gammaproteobacteria,1XU44@135623|Vibrionales 135623|Vibrionales M COG0668 Small-conductance mechanosensitive channel mscS - - ko:K03442 - - - - ko00000,ko02000 1.A.23.2 - - MS_channel,TM_helix k59_274099_1 1333998.M2A_1476 6.38e-33 124.0 COG3173@1|root,COG3173@2|Bacteria,1MWAK@1224|Proteobacteria,2TT2N@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Aminoglycoside phosphotransferase - - - - - - - - - - - - APH k59_274099_2 247633.GP2143_17911 1.25e-41 146.0 COG2141@1|root,COG2141@2|Bacteria 2|Bacteria C COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - - - - - - - - - - Bac_luciferase k59_495199_1 1122137.AQXF01000006_gene770 8.31e-132 379.0 COG0496@1|root,COG0496@2|Bacteria,1MVHE@1224|Proteobacteria,2TQXZ@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates surE - 3.1.3.5 ko:K03787 ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110 - R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346 RC00017 ko00000,ko00001,ko01000 - - - SurE k59_495199_2 1122137.AQXF01000006_gene771 1.94e-119 352.0 COG0172@1|root,COG0172@2|Bacteria,1MUJF@1224|Proteobacteria,2TR4T@28211|Alphaproteobacteria 28211|Alphaproteobacteria J Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) serS - 6.1.1.11 ko:K01875 ko00970,map00970 M00359,M00360 R03662,R08218 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Seryl_tRNA_N,tRNA-synt_2b k59_1794446_2 1229909.NSED_02795 1.1e-69 216.0 COG0169@1|root,arCOG02097@2157|Archaea,41SKU@651137|Thaumarchaeota 651137|Thaumarchaeota E Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3- dehydroshikimate aroD - 4.2.1.10 ko:K03785 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R03084 RC00848 ko00000,ko00001,ko00002,ko01000 - - - DHquinase_I k59_552112_1 216432.CA2559_06150 1.42e-94 282.0 COG2171@1|root,COG2171@2|Bacteria,4NEWD@976|Bacteroidetes,1HWTI@117743|Flavobacteriia 976|Bacteroidetes E Belongs to the transferase hexapeptide repeat family dapD - 2.3.1.117 ko:K00674 ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230 M00016 R04365 RC00004,RC01136 ko00000,ko00001,ko00002,ko01000 - - - Hexapep,Hexapep_2,THDPS_N_2 k59_838111_1 1323663.AROI01000009_gene3505 1.53e-62 199.0 COG4181@1|root,COG4181@2|Bacteria,1MXG9@1224|Proteobacteria,1RMG1@1236|Gammaproteobacteria 1236|Gammaproteobacteria Q (ABC) transporter ybbA GO:0000166,GO:0003674,GO:0005488,GO:0005524,GO:0008144,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_496526_1 1384056.N787_12390 4.15e-25 103.0 COG1294@1|root,COG1294@2|Bacteria,1MURP@1224|Proteobacteria,1RN0N@1236|Gammaproteobacteria,1X35A@135614|Xanthomonadales 135614|Xanthomonadales C oxidase, subunit II - - - - - - - - - - - - Cyt_bd_oxida_II k59_496526_2 1230476.C207_00724 2.24e-08 55.1 2E5W4@1|root,330K6@2|Bacteria,1N893@1224|Proteobacteria,2UGUZ@28211|Alphaproteobacteria,3JRW1@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S NIPSNAP - - - - - - - - - - - - NIPSNAP k59_1629713_1 436308.Nmar_1178 4.01e-08 53.1 arCOG11736@1|root,arCOG11736@2157|Archaea,41T70@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1629713_2 1229909.NSED_06590 2.46e-28 112.0 arCOG08686@1|root,arCOG08686@2157|Archaea,41T56@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_390256_1 228410.NE0209 1.34e-78 252.0 COG0449@1|root,COG0449@2|Bacteria,1MW4K@1224|Proteobacteria,2VHVY@28216|Betaproteobacteria,3721Z@32003|Nitrosomonadales 28216|Betaproteobacteria M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source glmS - 2.6.1.16 ko:K00820 ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931 - R00768 RC00010,RC00163,RC02752 ko00000,ko00001,ko01000,ko01002 - - - GATase_6,SIS k59_275448_1 472759.Nhal_3848 3.75e-67 216.0 COG1459@1|root,COG1459@2|Bacteria,1MV4U@1224|Proteobacteria,1RNV0@1236|Gammaproteobacteria,1WWAB@135613|Chromatiales 135613|Chromatiales U Type II secretion system - - - ko:K02653 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSF k59_275448_2 1515746.HR45_17505 3.62e-08 54.7 COG1989@1|root,COG1989@2|Bacteria,1MUZF@1224|Proteobacteria,1RN90@1236|Gammaproteobacteria,2Q91S@267890|Shewanellaceae 1236|Gammaproteobacteria M Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue pilD - 3.4.23.43 ko:K02464,ko:K02654 ko03070,map03070 M00331 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko02035,ko02044 3.A.15,3.A.15.2 - - DiS_P_DiS,Peptidase_A24 k59_1684944_1 10224.XP_006819722.1 1.6e-197 563.0 COG1838@1|root,2QT04@2759|Eukaryota,39WD1@33154|Opisthokonta,3BI53@33208|Metazoa,3D3TJ@33213|Bilateria 33208|Metazoa C Fumarase C-terminus - - 4.2.1.2 ko:K01676 ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374 R01082 RC00443 ko00000,ko00001,ko00002,ko01000 - - - Fumerase,Fumerase_C k59_1519405_1 1088721.NSU_0566 3.66e-41 155.0 COG4774@1|root,COG4774@2|Bacteria,1R9FU@1224|Proteobacteria,2U4AC@28211|Alphaproteobacteria,2K30U@204457|Sphingomonadales 204457|Sphingomonadales P TonB dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_496547_1 189425.PGRAT_24155 9.14e-11 61.2 28ZQ2@1|root,2ZMF3@2|Bacteria,1W1S0@1239|Firmicutes,4HZYI@91061|Bacilli,270FF@186822|Paenibacillaceae 91061|Bacilli - - - - - - - - - - - - - - - k59_441144_1 876044.IMCC3088_1087 1.5e-65 218.0 COG1884@1|root,COG2185@1|root,COG1884@2|Bacteria,COG2185@2|Bacteria,1MUXX@1224|Proteobacteria,1RSHX@1236|Gammaproteobacteria 1236|Gammaproteobacteria I Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly scpA GO:0003674,GO:0003824,GO:0004494,GO:0005488,GO:0008144,GO:0016853,GO:0016866,GO:0019842,GO:0031419,GO:0036094,GO:0046906,GO:0048037,GO:0097159,GO:1901363 5.4.99.2 ko:K01847,ko:K01848 ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200 M00373,M00375,M00376,M00741 R00833 RC00395 ko00000,ko00001,ko00002,ko01000 - - iECO111_1330.ECO111_3653,iECO26_1355.ECO26_4004 B12-binding,MM_CoA_mutase k59_441144_2 1121937.AUHJ01000001_gene341 3.94e-41 137.0 COG0346@1|root,COG0346@2|Bacteria,1RCYU@1224|Proteobacteria,1S4GD@1236|Gammaproteobacteria 1236|Gammaproteobacteria E COG0346 Lactoylglutathione lyase and related lyases mce - 5.1.99.1 ko:K05606 ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200 M00373,M00375,M00376,M00741 R02765,R09979 RC00780,RC02739 ko00000,ko00001,ko00002,ko01000 - - - Glyoxalase_4 k59_1344523_1 1123267.JONN01000002_gene187 4.01e-13 69.3 COG3741@1|root,COG3741@2|Bacteria,1MY4D@1224|Proteobacteria,2TUPZ@28211|Alphaproteobacteria,2K41R@204457|Sphingomonadales 204457|Sphingomonadales E N-formylglutamate amidohydrolase - - - - - - - - - - - - FGase k59_1128915_1 436308.Nmar_0303 1.15e-103 309.0 COG0598@1|root,arCOG02265@2157|Archaea,41SZC@651137|Thaumarchaeota 651137|Thaumarchaeota P Mg2 transporter protein - - - ko:K03284 - - - - ko00000,ko02000 1.A.35.1,1.A.35.3 - - CorA k59_676999_1 1121937.AUHJ01000015_gene138 3.4e-64 211.0 COG0402@1|root,COG0402@2|Bacteria,1MVPA@1224|Proteobacteria,1RN13@1236|Gammaproteobacteria,465K9@72275|Alteromonadaceae 1236|Gammaproteobacteria F Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine mtaD - - - - - - - - - - - Amidohydro_1 k59_562007_1 1499967.BAYZ01000028_gene1305 1.56e-69 220.0 COG0683@1|root,COG0683@2|Bacteria 2|Bacteria E ABC-type branched-chain amino acid transport systems, periplasmic component - - - ko:K01999 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - Peripla_BP_6 k59_562007_2 1307759.JOMJ01000003_gene1853 1.4e-05 46.2 COG0559@1|root,COG0559@2|Bacteria,1MU25@1224|Proteobacteria,42NME@68525|delta/epsilon subdivisions,2WJ4A@28221|Deltaproteobacteria,2M86U@213115|Desulfovibrionales 28221|Deltaproteobacteria E Belongs to the binding-protein-dependent transport system permease family livH - - ko:K01997 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - BPD_transp_2 k59_562019_1 1085623.GNIT_3493 1.83e-111 342.0 COG2943@1|root,COG2943@2|Bacteria,1MVXZ@1224|Proteobacteria,1RMGX@1236|Gammaproteobacteria,465E9@72275|Alteromonadaceae 1236|Gammaproteobacteria M COG2943 Membrane glycosyltransferase mdoH GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0005975,GO:0005976,GO:0006073,GO:0006950,GO:0006970,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009250,GO:0009628,GO:0009987,GO:0016020,GO:0016021,GO:0016051,GO:0016740,GO:0016757,GO:0031224,GO:0031226,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051273,GO:0051274,GO:0071704,GO:0071944,GO:1901576 - ko:K03669 - - - - ko00000,ko01000,ko01003,ko02000 4.D.3.1.1 GT2 - Glyco_trans_2_3,Glycos_transf_2 k59_506060_1 314278.NB231_13031 1.49e-12 62.8 COG0724@1|root,COG0724@2|Bacteria,1N6VR@1224|Proteobacteria,1SCKA@1236|Gammaproteobacteria,1WZAJ@135613|Chromatiales 135613|Chromatiales S COG0724 RNA-binding proteins (RRM domain) - - - - - - - - - - - - RRM_1 k59_1014281_2 1229909.NSED_09720 7.98e-38 130.0 arCOG10511@1|root,arCOG10511@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_1298095_1 446468.Ndas_0722 3.16e-14 72.4 COG2084@1|root,COG2084@2|Bacteria,2GNB0@201174|Actinobacteria,4EHG8@85012|Streptosporangiales 201174|Actinobacteria I NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase garR - 1.1.1.31,1.1.1.60 ko:K00020,ko:K00042 ko00280,ko00630,ko01100,map00280,map00630,map01100 - R01745,R01747,R05066 RC00099 ko00000,ko00001,ko01000 - - - NAD_binding_11,NAD_binding_2 k59_1298095_2 1122137.AQXF01000003_gene1997 2.25e-86 265.0 COG1024@1|root,COG1024@2|Bacteria,1MU0B@1224|Proteobacteria,2TQW3@28211|Alphaproteobacteria 28211|Alphaproteobacteria I enoyl-CoA hydratase hibch - 3.1.2.4,4.2.1.17 ko:K01692,ko:K05605 ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01200,map01212 M00013,M00032,M00087 R03026,R03045,R03158,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05064,R05595,R06411,R06412,R06942,R08093 RC00004,RC00014,RC00137,RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 - - - ECH_2 k59_1467764_1 889378.Spiaf_0207 5.79e-23 103.0 COG2114@1|root,COG4252@1|root,COG2114@2|Bacteria,COG4252@2|Bacteria,2J6FV@203691|Spirochaetes 203691|Spirochaetes T Adenylate guanylate cyclase catalytic domain protein - - 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 - - - CHASE2,Guanylate_cyc k59_562059_1 522306.CAP2UW1_0701 6.23e-92 281.0 COG1686@1|root,COG1686@2|Bacteria,1MUU7@1224|Proteobacteria,2VH46@28216|Betaproteobacteria,1KPVQ@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria M Belongs to the peptidase S11 family dacC - 3.4.16.4 ko:K01286,ko:K07258 ko00550,ko01100,map00550,map01100 - - - ko00000,ko00001,ko01000,ko01002,ko01011 - - - PBP5_C,Peptidase_S11 k59_1694883_1 1279017.AQYJ01000023_gene3250 1.58e-91 284.0 COG1012@1|root,COG1012@2|Bacteria,1MVGW@1224|Proteobacteria,1RN53@1236|Gammaproteobacteria,4656Y@72275|Alteromonadaceae 1236|Gammaproteobacteria C belongs to the aldehyde dehydrogenase family ywdH - 1.2.1.3 ko:K00128 ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130 M00135 R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146 RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_1694892_1 243365.CV_2321 4.43e-52 182.0 COG0497@1|root,COG0497@2|Bacteria,1MUNP@1224|Proteobacteria,2VHHA@28216|Betaproteobacteria,2KPNM@206351|Neisseriales 206351|Neisseriales L May be involved in recombinational repair of damaged DNA recN - - ko:K03631 - - - - ko00000,ko03400 - - - SMC_N k59_1694892_2 204773.HEAR2652 1.42e-08 55.8 COG0061@1|root,COG0061@2|Bacteria,1MUBC@1224|Proteobacteria,2VIV0@28216|Betaproteobacteria,472PK@75682|Oxalobacteraceae 28216|Betaproteobacteria H Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP nadK - 2.7.1.23 ko:K00858 ko00760,ko01100,map00760,map01100 - R00104 RC00002,RC00078 ko00000,ko00001,ko01000 - - - NAD_kinase k59_1467796_1 436308.Nmar_1389 2.52e-117 341.0 COG0543@1|root,arCOG02199@2157|Archaea,41SY5@651137|Thaumarchaeota 651137|Thaumarchaeota H Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B - - - ko:K02823 ko00240,ko01100,map00240,map01100 - - - ko00000,ko00001 - - - DHODB_Fe-S_bind,NAD_binding_1 k59_1467796_2 436308.Nmar_1390 7.04e-36 129.0 COG0167@1|root,arCOG00603@2157|Archaea 2157|Archaea F Catalyzes the conversion of dihydroorotate to orotate pyrD GO:0003674,GO:0003824,GO:0004152,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006206,GO:0006207,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009987,GO:0016491,GO:0016627,GO:0016635,GO:0018130,GO:0019856,GO:0034641,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046112,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 1.3.1.1,1.3.1.14,1.3.5.2,1.3.98.1 ko:K00226,ko:K00254,ko:K17723,ko:K17828 ko00240,ko00410,ko00770,ko01100,map00240,map00410,map00770,map01100 M00046,M00051 R00977,R01414,R01867,R01868,R01869,R11026 RC00051,RC00072,RC00123 ko00000,ko00001,ko00002,ko01000 - - - DHO_dh k59_506128_1 1144325.PMI22_04902 3.49e-74 238.0 COG1622@1|root,COG2010@1|root,COG1622@2|Bacteria,COG2010@2|Bacteria,1MVYW@1224|Proteobacteria,1RY2R@1236|Gammaproteobacteria 1236|Gammaproteobacteria C COG1622 Heme copper-type cytochrome quinol oxidases, subunit 2 - - 1.9.3.1 ko:K02275 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.4,3.D.4.6 - - COX2,COX2_TM,Cytochrom_C k59_450902_1 269796.Rru_A0002 3.91e-73 231.0 COG0592@1|root,COG0592@2|Bacteria,1MVD9@1224|Proteobacteria,2TSRZ@28211|Alphaproteobacteria,2JQAW@204441|Rhodospirillales 204441|Rhodospirillales L Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria dnaN - 2.7.7.7 ko:K02338 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_beta,DNA_pol3_beta_2,DNA_pol3_beta_3 k59_1804308_1 1082931.KKY_3786 7.54e-06 52.0 COG3473@1|root,COG3473@2|Bacteria,1N3F7@1224|Proteobacteria,2TUQE@28211|Alphaproteobacteria,3N6GC@45401|Hyphomicrobiaceae 28211|Alphaproteobacteria G Catalyzes the conversion of maleate to fumarate maiA - 5.2.1.1 ko:K01799 ko00650,ko00760,ko01120,map00650,map00760,map01120 M00622 R01087 RC00448 ko00000,ko00001,ko00002,ko01000 - - - - k59_562125_2 1122137.AQXF01000004_gene1603 3.1e-74 234.0 COG0593@1|root,COG0593@2|Bacteria,1MU5H@1224|Proteobacteria,2TT03@28211|Alphaproteobacteria 28211|Alphaproteobacteria L it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids dnaA GO:0003674,GO:0003676,GO:0003677,GO:0003688,GO:0003690,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0034641,GO:0034645,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901576,GO:1990837 - ko:K02313 ko02020,ko04112,map02020,map04112 - - - ko00000,ko00001,ko03032,ko03036 - - - Bac_DnaA,Bac_DnaA_C,DnaA_N k59_788368_1 688270.Celal_0061 7.1e-10 65.5 COG3291@1|root,COG3291@2|Bacteria,4PG3Q@976|Bacteroidetes,1IGZD@117743|Flavobacteriia,1FA0X@104264|Cellulophaga 976|Bacteroidetes E Domain of unknown function (DUF5011) - - - - - - - - - - - - DUF5011 k59_1014383_2 1229909.NSED_06205 3.72e-65 200.0 arCOG08684@1|root,arCOG08684@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_450922_1 765911.Thivi_2946 8.02e-144 418.0 COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,1RMAQ@1236|Gammaproteobacteria,1WXTC@135613|Chromatiales 135613|Chromatiales L transposase IS116 IS110 IS902 family - - - ko:K07486 - - - - ko00000 - - - DEDD_Tnp_IS110,Transposase_20 k59_1354176_1 637905.SVI_0139 3.18e-30 122.0 COG0339@1|root,COG0339@2|Bacteria,1MU1K@1224|Proteobacteria,1RMAH@1236|Gammaproteobacteria,2Q9RZ@267890|Shewanellaceae 1236|Gammaproteobacteria E PFAM peptidase M3A and M3B, thimet oligopeptidase F prlC GO:0003674,GO:0003824,GO:0004175,GO:0004222,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006465,GO:0006508,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016485,GO:0016787,GO:0019538,GO:0034641,GO:0034645,GO:0043170,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051604,GO:0070011,GO:0071704,GO:0090304,GO:0140096,GO:1901360,GO:1901564,GO:1901576 3.4.24.70 ko:K01414 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M3 k59_1014402_1 1298593.TOL_0898 5.92e-30 117.0 COG1196@1|root,COG1196@2|Bacteria,1NGHR@1224|Proteobacteria,1RQW7@1236|Gammaproteobacteria,1XKSV@135619|Oceanospirillales 135619|Oceanospirillales D Protein of unknown function (DUF3450) - - - - - - - - - - - - DUF3450 k59_677107_1 580332.Slit_2514 1.65e-33 125.0 COG0842@1|root,COG0842@2|Bacteria,1MW5R@1224|Proteobacteria,2VKHP@28216|Betaproteobacteria 28216|Betaproteobacteria V ABC-2 type transporter - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_3 k59_677107_2 580332.Slit_2515 4.91e-47 162.0 COG0842@1|root,COG0842@2|Bacteria,1MW5R@1224|Proteobacteria,2VKHP@28216|Betaproteobacteria 28216|Betaproteobacteria V ABC-2 type transporter - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_3 k59_562188_1 247639.MGP2080_15914 2.49e-13 73.2 COG0673@1|root,COG0673@2|Bacteria,1MZIG@1224|Proteobacteria,1RS5T@1236|Gammaproteobacteria,1JAYB@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Oxidoreductase family, NAD-binding Rossmann fold - - - - - - - - - - - - GFO_IDH_MocA,GFO_IDH_MocA_C k59_1014435_1 519442.Huta_1252 3.3e-11 66.6 COG0492@1|root,arCOG01296@2157|Archaea,2XUYB@28890|Euryarchaeota,23UE3@183963|Halobacteria 183963|Halobacteria O Pyridine nucleotide-disulphide oxidoreductase - - 1.8.1.9 ko:K00384 ko00450,map00450 - R02016,R03596,R09372 RC00013,RC02518,RC02873 ko00000,ko00001,ko01000 - - - Pyr_redox_2,Pyr_redox_3 k59_1014435_2 103733.JNYO01000003_gene8118 1.89e-59 199.0 COG3486@1|root,COG3486@2|Bacteria,2GKTG@201174|Actinobacteria,4DZIB@85010|Pseudonocardiales 201174|Actinobacteria Q L-lysine 6-monooxygenase (NADPH-requiring) iucD - 1.14.13.195,1.14.13.196,1.14.13.59 ko:K03897,ko:K10531 ko00310,ko01120,map00310,map01120 - R00448 RC00298 ko00000,ko00001,ko01000 - - - K_oxygenase k59_450982_1 452662.SJA_C2-00940 8.86e-40 150.0 COG4993@1|root,COG4993@2|Bacteria,1MUQX@1224|Proteobacteria,2TQMV@28211|Alphaproteobacteria,2K0W1@204457|Sphingomonadales 204457|Sphingomonadales G Glucose dehydrogenase - - 1.1.5.2,1.1.5.8 ko:K00117,ko:K05358 ko00030,ko00400,ko01100,ko01110,ko01130,map00030,map00400,map01100,map01110,map01130 - R01873,R02415,R06620 RC00066,RC00154,RC00206 ko00000,ko00001,ko01000 - - - PQQ,PQQ_2 k59_1129059_1 305900.GV64_07995 1.85e-55 177.0 COG1970@1|root,COG1970@2|Bacteria,1RHG8@1224|Proteobacteria,1S3PD@1236|Gammaproteobacteria,1XKKT@135619|Oceanospirillales 135619|Oceanospirillales M Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell mscL - - ko:K03282 - - - - ko00000,ko02000 1.A.22.1 - - MscL k59_1129059_2 1416759.AYMR01000009_gene2769 2.15e-16 82.8 COG1028@1|root,COG1028@2|Bacteria,2GIYQ@201174|Actinobacteria,4FN2B@85023|Microbacteriaceae 201174|Actinobacteria IQ Enoyl-(Acyl carrier protein) reductase - - - - - - - - - - - - adh_short k59_1129064_2 765912.Thimo_2519 8.9e-38 138.0 COG4591@1|root,COG4591@2|Bacteria,1R4Q2@1224|Proteobacteria,1RQW0@1236|Gammaproteobacteria,1X1HR@135613|Chromatiales 135613|Chromatiales M ABC-type transport system, involved in lipoprotein release, permease component - - - - - - - - - - - - FtsX,MacB_PCD k59_1014452_1 1122137.AQXF01000002_gene28 2.97e-78 242.0 COG3267@1|root,COG3267@2|Bacteria,1MU3G@1224|Proteobacteria,2U1EJ@28211|Alphaproteobacteria 28211|Alphaproteobacteria U Type II secretory pathway, component ExeA exeA - - - - - - - - - - - AAA_22 k59_1014452_2 1122137.AQXF01000002_gene27 2.94e-201 574.0 COG5338@1|root,COG5338@2|Bacteria,1RHNA@1224|Proteobacteria 1224|Proteobacteria S Protein conserved in bacteria - - - - - - - - - - - - BBP2_2 k59_1014455_1 706587.Desti_2062 5.03e-08 56.2 COG0662@1|root,COG1426@1|root,COG0662@2|Bacteria,COG1426@2|Bacteria 2|Bacteria S sequence-specific DNA binding - - - - - - - - - - - - Cupin_2,HTH_19,HTH_25,HTH_3,HTH_31 k59_1014455_2 1390370.O203_11085 6.23e-15 72.8 COG0346@1|root,COG0346@2|Bacteria,1RJR7@1224|Proteobacteria,1S71Y@1236|Gammaproteobacteria,1YG07@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria E Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - - - - - - - - - - Glyoxalase k59_677155_1 1122137.AQXF01000005_gene1189 5.71e-139 411.0 COG0370@1|root,COG0370@2|Bacteria,1MUZC@1224|Proteobacteria,2TQSU@28211|Alphaproteobacteria 28211|Alphaproteobacteria P Ferrous iron transport protein B feoB - - ko:K04759 - - - - ko00000,ko02000 9.A.8.1 - - FeoB_C,FeoB_N,Gate k59_1129071_1 243233.MCA0016 5.13e-135 402.0 COG0073@1|root,COG0143@1|root,COG0073@2|Bacteria,COG0143@2|Bacteria,1MUBY@1224|Proteobacteria,1RMYM@1236|Gammaproteobacteria,1XE7K@135618|Methylococcales 135618|Methylococcales J Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation metG - 6.1.1.10 ko:K01874 ko00450,ko00970,map00450,map00970 M00359,M00360 R03659,R04773 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,tRNA-synt_1g,tRNA_bind k59_847630_1 225937.HP15_2623 3.67e-30 118.0 COG0334@1|root,COG0334@2|Bacteria,1MUXS@1224|Proteobacteria,1RQ0T@1236|Gammaproteobacteria,4648M@72275|Alteromonadaceae 1236|Gammaproteobacteria E Belongs to the Glu Leu Phe Val dehydrogenases family ldh - 1.4.1.9 ko:K00263 ko00280,ko00290,ko01100,ko01110,ko01130,map00280,map00290,map01100,map01110,map01130 - R01088,R01434,R02196 RC00006,RC00036 ko00000,ko00001,ko01000 - - - ELFV_dehydrog,ELFV_dehydrog_N k59_1525618_1 1120972.AUMH01000007_gene1715 2.92e-50 182.0 COG1198@1|root,COG1198@2|Bacteria,1TNYB@1239|Firmicutes,4H9WW@91061|Bacilli,27835@186823|Alicyclobacillaceae 91061|Bacilli L Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA priA GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006268,GO:0006270,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0033554,GO:0034641,GO:0034645,GO:0042623,GO:0043138,GO:0043140,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0046483,GO:0050896,GO:0051276,GO:0051716,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360,GO:1901576 - ko:K04066 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,Helicase_C,ResIII k59_1017179_1 1122137.AQXF01000003_gene2473 1.6e-113 343.0 COG0768@1|root,COG0768@2|Bacteria,1MV8C@1224|Proteobacteria,2TRXN@28211|Alphaproteobacteria 28211|Alphaproteobacteria M COG0768 cell division protein FtsI penicillin-binding protein 2 mrdA - 3.4.16.4 ko:K05515 ko00550,ko01501,map00550,map01501 - - - ko00000,ko00001,ko01000,ko01011 - - - PBP_dimer,Transpeptidase k59_169663_2 1552123.EP57_02685 3.46e-14 78.6 COG2244@1|root,COG2244@2|Bacteria,1V90S@1239|Firmicutes,4HJC1@91061|Bacilli,26N4V@186820|Listeriaceae 91061|Bacilli S Polysaccharide biosynthesis protein - - - - - - - - - - - - Polysacc_synt_3 k59_1525628_1 981369.JQMJ01000001_gene6762 1.61e-19 92.4 COG0642@1|root,COG0642@2|Bacteria,COG2205@2|Bacteria,2I2M2@201174|Actinobacteria,2NNJM@228398|Streptacidiphilus 201174|Actinobacteria T Histidine Phosphotransfer domain - - - - - - - - - - - - HAMP,HATPase_c,HisKA,Hpt,Response_reg,dCache_1 k59_1525628_2 1122137.AQXF01000001_gene3306 1.21e-24 112.0 COG1629@1|root,COG4771@2|Bacteria,1MWKN@1224|Proteobacteria,2U3ES@28211|Alphaproteobacteria 28211|Alphaproteobacteria P TonB-dependent receptor plug - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_678150_1 1415778.JQMM01000001_gene4 3.29e-84 265.0 COG4783@1|root,COG4783@2|Bacteria,1MVFV@1224|Proteobacteria,1RP5S@1236|Gammaproteobacteria,1J5N2@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Functions as both a chaperone and a metalloprotease. Maintains the integrity of the outer membrane by promoting either the assembly or the elimination of outer membrane proteins, depending on their folding state bepA GO:0003674,GO:0003756,GO:0003824,GO:0004175,GO:0004222,GO:0005488,GO:0005575,GO:0005623,GO:0006457,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009056,GO:0009057,GO:0009987,GO:0016020,GO:0016043,GO:0016787,GO:0016853,GO:0016860,GO:0016864,GO:0019538,GO:0022607,GO:0030163,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043163,GO:0043165,GO:0043167,GO:0043169,GO:0043170,GO:0044085,GO:0044091,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044464,GO:0045229,GO:0046872,GO:0051603,GO:0061024,GO:0061077,GO:0070011,GO:0071704,GO:0071709,GO:0071840,GO:0140096,GO:1901564,GO:1901565,GO:1901575 - - - - - - - - - - Peptidase_M48,TPR_19 k59_678150_2 1179778.PMM47T1_03089 1.15e-13 71.6 COG0628@1|root,COG0628@2|Bacteria,1MW0B@1224|Proteobacteria,1RPVP@1236|Gammaproteobacteria 1236|Gammaproteobacteria S permease perM GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944 - ko:K03548 - - - - ko00000,ko02000 2.A.86.1 - - AI-2E_transport k59_1130177_1 279238.Saro_2803 2.45e-195 569.0 COG4774@1|root,COG4774@2|Bacteria,1NSA5@1224|Proteobacteria,2UNVI@28211|Alphaproteobacteria,2K93P@204457|Sphingomonadales 204457|Sphingomonadales P TonB dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_508666_1 446470.Snas_0922 6.25e-62 194.0 COG0102@1|root,COG0102@2|Bacteria,2IFG1@201174|Actinobacteria,4EYPN@85014|Glycomycetales 201174|Actinobacteria J Ribosomal protein L13 rplM GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0019538,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02871 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L13 k59_169677_1 1288494.EBAPG3_25340 3.04e-35 130.0 COG1459@1|root,COG1459@2|Bacteria,1MV4U@1224|Proteobacteria,2VM1X@28216|Betaproteobacteria,374KT@32003|Nitrosomonadales 28216|Betaproteobacteria U Type II secretion system (T2SS), protein F gspF - - ko:K02455 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - T2SSF k59_169677_2 1125863.JAFN01000001_gene2969 3.9e-20 91.3 COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,42M51@68525|delta/epsilon subdivisions,2WIPP@28221|Deltaproteobacteria 28221|Deltaproteobacteria NU PFAM Type II secretion system protein E gspE - - ko:K02454 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - T2SSE,T2SSE_N k59_1469130_1 436308.Nmar_0299 9.73e-117 349.0 COG0036@1|root,COG3959@1|root,arCOG01053@2157|Archaea,arCOG05046@2157|Archaea,41SBE@651137|Thaumarchaeota 651137|Thaumarchaeota G Transketolase, thiamine diphosphate binding domain - - 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 - - - Ribul_P_3_epim,Transketolase_N k59_186_1 649638.Trad_0374 2.58e-79 251.0 KOG2524@1|root,2ZJ84@2|Bacteria 2|Bacteria S Potential Queuosine, Q, salvage protein family - - - - - - - - - - - - Q_salvage k59_847651_1 1122137.AQXF01000003_gene1915 1.59e-37 140.0 COG0477@1|root,COG2814@2|Bacteria,1MU1I@1224|Proteobacteria,2TVXT@28211|Alphaproteobacteria 28211|Alphaproteobacteria EGP Major facilitator Superfamily emrB - - ko:K03446 - M00701 - - ko00000,ko00002,ko02000 2.A.1.3 - - MFS_1 k59_847651_2 1122137.AQXF01000003_gene1914 2.47e-20 85.9 COG0176@1|root,COG0176@2|Bacteria,1MWQ8@1224|Proteobacteria,2TQJB@28211|Alphaproteobacteria 28211|Alphaproteobacteria G Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway tal GO:0003674,GO:0003824,GO:0006002,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016829,GO:0016830,GO:0016832,GO:0019637,GO:0044237,GO:0071704,GO:1901135 2.2.1.2 ko:K00616 ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007 R01827 RC00439,RC00604 ko00000,ko00001,ko00002,ko01000 - - - TAL_FSA k59_56702_1 926556.Echvi_2225 1.32e-171 493.0 COG3039@1|root,COG3039@2|Bacteria,4NGW9@976|Bacteroidetes,47SIQ@768503|Cytophagia 976|Bacteroidetes L PFAM Transposase domain (DUF772) - - - - - - - - - - - - DDE_Tnp_1_2,DUF772 k59_1525637_1 1118153.MOY_02989 1.47e-06 53.1 COG2951@1|root,COG2951@2|Bacteria,1MUZ3@1224|Proteobacteria,1RMQ6@1236|Gammaproteobacteria,1XIS6@135619|Oceanospirillales 135619|Oceanospirillales M Lytic murein transglycosylase B mltB - - ko:K08305 - - - - ko00000,ko01000,ko01011 - GH103 - SLT_2 k59_1525637_2 519989.ECTPHS_02511 1.83e-31 119.0 COG0772@1|root,COG0772@2|Bacteria,1MUK3@1224|Proteobacteria,1RMEJ@1236|Gammaproteobacteria,1WWAV@135613|Chromatiales 135613|Chromatiales M Peptidoglycan polymerase that is essential for cell wall elongation mrdB - - ko:K05837 - - - - ko00000,ko03036 - - - FTSW_RODA_SPOVE k59_678159_1 29581.BW37_05350 4e-35 124.0 COG3267@1|root,COG3267@2|Bacteria,1MU3G@1224|Proteobacteria,2VIK1@28216|Betaproteobacteria,472FY@75682|Oxalobacteraceae 28216|Betaproteobacteria U Putative peptidoglycan binding domain exeA - - ko:K02450 - M00331 - - ko00000,ko00002,ko02044 9.B.42 - - AAA_22,PG_binding_1 k59_678159_2 1278073.MYSTI_03647 1.12e-104 311.0 COG2801@1|root,COG2801@2|Bacteria,1MVXQ@1224|Proteobacteria,42M98@68525|delta/epsilon subdivisions,2WMKB@28221|Deltaproteobacteria 28221|Deltaproteobacteria L PFAM Integrase catalytic - - - ko:K07497 - - - - ko00000 - - - HTH_21,HTH_Tnp_1,rve k59_565223_1 876044.IMCC3088_1700 2.74e-67 211.0 COG0106@1|root,COG0106@2|Bacteria,1MW6S@1224|Proteobacteria,1RN3M@1236|Gammaproteobacteria,1J5HX@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E 1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase hisA - 5.3.1.16,5.3.1.24 ko:K01814,ko:K01817 ko00340,ko00400,ko01100,ko01110,ko01130,ko01230,map00340,map00400,map01100,map01110,map01130,map01230 M00023,M00026 R03509,R04640 RC00945 ko00000,ko00001,ko00002,ko01000 - - - His_biosynth k59_395676_1 583355.Caka_1840 3.39e-58 202.0 COG5373@1|root,COG5373@2|Bacteria,46ZI2@74201|Verrucomicrobia,3KA23@414999|Opitutae 414999|Opitutae S Predicted membrane protein (DUF2339) - - - - - - - - - - - - DUF2339 k59_1695123_1 234267.Acid_7382 3.04e-85 271.0 COG2303@1|root,COG2303@2|Bacteria,3Y6UA@57723|Acidobacteria 57723|Acidobacteria E GMC oxidoreductase - - - - - - - - - - - - GMC_oxred_C,GMC_oxred_N k59_1299705_2 1229909.NSED_08320 6.84e-24 94.4 COG1325@1|root,arCOG01042@2157|Archaea,41SWK@651137|Thaumarchaeota 651137|Thaumarchaeota J RNA binding - - - ko:K07581 - - - - ko00000 - - - RNA_binding k59_1356158_1 468059.AUHA01000002_gene540 2.54e-37 148.0 COG0612@1|root,COG0612@2|Bacteria,4NFY0@976|Bacteroidetes,1IP4P@117747|Sphingobacteriia 976|Bacteroidetes S Peptidase M16 - - - ko:K07263 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M16,Peptidase_M16_C k59_1525658_1 759362.KVU_0961 1.56e-42 149.0 COG0468@1|root,COG0468@2|Bacteria,1MU3C@1224|Proteobacteria,2TRPR@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage recA GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716,GO:0071496 - ko:K03553 ko03440,map03440 M00729 - - ko00000,ko00001,ko00002,ko03400 - - - RecA k59_282766_1 1122614.JHZF01000013_gene3463 2.07e-22 99.4 COG0659@1|root,COG0659@2|Bacteria,1MWDF@1224|Proteobacteria,2TT0G@28211|Alphaproteobacteria 28211|Alphaproteobacteria P COG0659 Sulfate permease and related transporters (MFS superfamily - - - ko:K03321 - - - - ko00000,ko02000 2.A.53.3 - - STAS,Sulfate_transp k59_1356162_1 1487953.JMKF01000039_gene3016 1.61e-19 82.4 COG3251@1|root,COG3251@2|Bacteria 2|Bacteria P PFAM MbtH domain protein - - - ko:K05375 ko00261,ko01130,map00261,map01130 M00736 R10880 RC00064,RC00141,RC03296,RC03297,RC03298 ko00000,ko00001,ko00002 - - - CBF_beta,MbtH k59_214_1 1122137.AQXF01000003_gene2352 1.11e-139 409.0 COG0318@1|root,COG0318@2|Bacteria,1MUMC@1224|Proteobacteria,2TR96@28211|Alphaproteobacteria 28211|Alphaproteobacteria IQ COG0318, Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II - - 6.2.1.48 ko:K00666,ko:K02182 - - - - ko00000,ko01000,ko01004 - - - AMP-binding,AMP-binding_C k59_214_2 1333998.M2A_2406 1.16e-34 123.0 COG5646@1|root,COG5646@2|Bacteria,1N03F@1224|Proteobacteria,2U57T@28211|Alphaproteobacteria 28211|Alphaproteobacteria S InterPro IPR014922 - - - - - - - - - - - - DUF1801 k59_734737_1 565045.NOR51B_1638 2.02e-43 160.0 COG0532@1|root,COG0532@2|Bacteria,1MV26@1224|Proteobacteria,1RM9X@1236|Gammaproteobacteria,1J4HS@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex infB GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003676,GO:0003723,GO:0003743,GO:0003824,GO:0003924,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006413,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019538,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034641,GO:0034645,GO:0036094,GO:0043021,GO:0043024,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0097159,GO:0097216,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - ko:K02519 - - - - ko00000,ko03012,ko03029 - - - GTP_EFTU,GTP_EFTU_D2,IF-2,IF2_N,IF2_assoc k59_401880_1 926569.ANT_01020 1.96e-18 84.3 COG3464@1|root,COG3464@2|Bacteria,2G9B1@200795|Chloroflexi 200795|Chloroflexi L Transposase IS66 family - - - - - - - - - - - - DDE_Tnp_IS66 k59_232152_1 378806.STAUR_6825 1.58e-190 564.0 COG1703@1|root,COG1884@1|root,COG2185@1|root,COG1703@2|Bacteria,COG1884@2|Bacteria,COG2185@2|Bacteria,1MUXX@1224|Proteobacteria,42MVK@68525|delta/epsilon subdivisions,2WKEN@28221|Deltaproteobacteria,2YWT4@29|Myxococcales 28221|Deltaproteobacteria F Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly icmF - 5.4.99.13 ko:K11942 - - - - ko00000,ko01000 - - - ArgK,B12-binding,MM_CoA_mutase k59_119942_1 1291050.JAGE01000001_gene312 2.21e-25 110.0 COG1404@1|root,COG3209@1|root,COG1404@2|Bacteria,COG3209@2|Bacteria,1TR8F@1239|Firmicutes,248C6@186801|Clostridia,3WNZA@541000|Ruminococcaceae 186801|Clostridia M RHS Repeat - - - - - - - - - - - - Peptidase_S8,RHS_repeat k59_1024050_1 383407.XOC_0646 5.94e-58 191.0 COG3677@1|root,COG3677@2|Bacteria,1NUTK@1224|Proteobacteria,1S11R@1236|Gammaproteobacteria,1XCXA@135614|Xanthomonadales 135614|Xanthomonadales L ISXO2-like transposase domain - - - - - - - - - - - - DDE_Tnp_IS1595,Zn_Tnp_IS1595 k59_1306218_2 1242864.D187_009512 3.85e-23 98.6 COG0484@1|root,COG0484@2|Bacteria,1NT8N@1224|Proteobacteria,42YPD@68525|delta/epsilon subdivisions,2WTQY@28221|Deltaproteobacteria 28221|Deltaproteobacteria O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins - - - ko:K03686 - - - - ko00000,ko03029,ko03110 - - - DnaJ,DnaJ_C,DnaJ_CXXCXGXG k59_966732_1 1122137.AQXF01000004_gene1431 1.29e-89 278.0 COG0168@1|root,COG0168@2|Bacteria,1MUIJ@1224|Proteobacteria,2TRPX@28211|Alphaproteobacteria 28211|Alphaproteobacteria P Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA - - - ko:K03498 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - - TrkH k59_1532196_1 267608.RSc2376 5.82e-48 174.0 COG1148@1|root,COG1148@2|Bacteria,1QUQG@1224|Proteobacteria,2VMBE@28216|Betaproteobacteria,1K513@119060|Burkholderiaceae 28216|Betaproteobacteria C Ferredoxin - - - - - - - - - - - - Fer4,Fer4_4,Fer4_6,Fer4_7 k59_458421_1 314254.OA2633_03791 7.42e-16 84.7 COG3209@1|root,COG3209@2|Bacteria,1MVV1@1224|Proteobacteria,2U4RY@28211|Alphaproteobacteria,43YWV@69657|Hyphomonadaceae 28211|Alphaproteobacteria M TIGRFAM RHS repeat-associated core domain-containing protein, YD repeat protein - - - - - - - - - - - - RHS_repeat,SpvB,TcdB_toxin_midN k59_289549_1 1276756.AUEX01000001_gene905 2.28e-81 263.0 COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,2VIR8@28216|Betaproteobacteria,4ACHC@80864|Comamonadaceae 28216|Betaproteobacteria C aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding coxL - 1.2.5.3 ko:K03520 - - R11168 RC02800 ko00000,ko01000 - - - Ald_Xan_dh_C,Ald_Xan_dh_C2 k59_401890_1 247156.NFA_6180 3.49e-28 119.0 COG2937@1|root,COG2937@2|Bacteria,2GMQF@201174|Actinobacteria,4FWRE@85025|Nocardiaceae 201174|Actinobacteria I Belongs to the GPAT DAPAT family plsB GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 2.3.1.15 ko:K00631 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R00851,R09380 RC00004,RC00039,RC00041 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Acyltransferase k59_119953_1 381666.H16_A1575 4.72e-45 150.0 COG3339@1|root,COG3339@2|Bacteria,1MZCY@1224|Proteobacteria,2VSZM@28216|Betaproteobacteria,1KDH5@119060|Burkholderiaceae 28216|Betaproteobacteria S Protein of unknown function (DUF1232) - - - - - - - - - - - - DUF1232 k59_1645234_1 1122137.AQXF01000005_gene1073 1.1e-145 417.0 COG0685@1|root,COG0685@2|Bacteria,1MUC9@1224|Proteobacteria,2TQZA@28211|Alphaproteobacteria 28211|Alphaproteobacteria E reductase metF GO:0003674,GO:0003824,GO:0004489,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006730,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016645,GO:0016646,GO:0044237,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0055114 1.5.1.20 ko:K00297 ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,map00670,map00720,map01100,map01120,map01200,map01523 M00377 R01224,R07168 RC00081 ko00000,ko00001,ko00002,ko01000 - - - MTHFR k59_458429_1 436308.Nmar_0620 5.27e-118 354.0 COG3356@1|root,arCOG04351@2157|Archaea,41S7S@651137|Thaumarchaeota 651137|Thaumarchaeota S Predicted membrane protein (DUF2070) - - - ko:K08979 - - - - ko00000 - - - DUF2070 k59_1192946_1 640081.Dsui_3135 1.49e-57 192.0 COG0330@1|root,COG0330@2|Bacteria,1MUM2@1224|Proteobacteria,2VIG2@28216|Betaproteobacteria,2KUKU@206389|Rhodocyclales 206389|Rhodocyclales O HflC and HflK could encode or regulate a protease - - - ko:K04088 - M00742 - - ko00000,ko00002,ko01000 - - - Band_7,HflK_N k59_232171_1 397945.Aave_4553 5.58e-86 262.0 COG0289@1|root,COG0289@2|Bacteria,1MUCT@1224|Proteobacteria,2VJC3@28216|Betaproteobacteria,4AAJX@80864|Comamonadaceae 28216|Betaproteobacteria E Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate dapB GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008839,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0019752,GO:0019877,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576 1.17.1.8 ko:K00215 ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R04198,R04199 RC00478 ko00000,ko00001,ko00002,ko01000 - - - DapB_C,DapB_N k59_175948_1 1380394.JADL01000010_gene4230 5.23e-22 93.6 COG2020@1|root,COG2020@2|Bacteria,1MWU6@1224|Proteobacteria,2TU80@28211|Alphaproteobacteria,2JU60@204441|Rhodospirillales 204441|Rhodospirillales O methyltransferase activity - - - - - - - - - - - - PEMT k59_1024084_1 1122139.KB907897_gene3179 2.91e-31 125.0 COG0719@1|root,COG0719@2|Bacteria,1MVK0@1224|Proteobacteria,1RP2A@1236|Gammaproteobacteria,1XINT@135619|Oceanospirillales 135619|Oceanospirillales O COG0719 ABC-type transport system involved in Fe-S cluster assembly, permease component sufD - - ko:K09015 - - - - ko00000 - - - UPF0051 k59_1363396_1 493475.GARC_0456 1.37e-14 84.0 COG0642@1|root,COG0642@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,1SKTW@1236|Gammaproteobacteria,463ZD@72275|Alteromonadaceae 1236|Gammaproteobacteria T COG0642 Signal transduction histidine kinase - - - - - - - - - - - - HAMP,HATPase_c,HisKA,Hpt,PAS,PAS_3,PAS_4,PAS_9,Response_reg,dCache_1 k59_1476597_2 1122611.KB903960_gene4315 9.63e-40 150.0 COG3321@1|root,COG3321@2|Bacteria,2H477@201174|Actinobacteria,4EHXQ@85012|Streptosporangiales 201174|Actinobacteria Q PKS_KR pks13 - - ko:K12437,ko:K12443 - - - - ko00000,ko01004 - - - Acyl_transf_1,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,PS-DH,Thioesterase,ketoacyl-synt k59_685085_1 290397.Adeh_1613 1.21e-62 218.0 COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,42N8M@68525|delta/epsilon subdivisions,2WJRT@28221|Deltaproteobacteria,2YUBZ@29|Myxococcales 28221|Deltaproteobacteria F Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen nrdA1 - 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - Ribonuc_red_2_N,Ribonuc_red_lgC k59_7703_1 316067.Geob_3299 1.11e-05 52.0 COG0583@1|root,COG0583@2|Bacteria,1MWVU@1224|Proteobacteria,42PMQ@68525|delta/epsilon subdivisions,2WKB8@28221|Deltaproteobacteria,43T3W@69541|Desulfuromonadales 28221|Deltaproteobacteria K LysR substrate binding domain - - - - - - - - - - - - HTH_1,LysR_substrate k59_7703_2 1042377.AFPJ01000008_gene2000 1.24e-28 108.0 COG3473@1|root,COG3473@2|Bacteria,1RB05@1224|Proteobacteria,1S5KQ@1236|Gammaproteobacteria 1236|Gammaproteobacteria Q Asp Glu racemase - - 5.2.1.1 ko:K01799 ko00650,ko00760,ko01120,map00650,map00760,map01120 M00622 R01087 RC00448 ko00000,ko00001,ko00002,ko01000 - - - Asp_Glu_race k59_1646056_1 861299.J421_0563 8.44e-156 464.0 COG1472@1|root,COG1472@2|Bacteria 2|Bacteria G Belongs to the glycosyl hydrolase 3 family - - 3.2.1.21 ko:K05349 ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110 - R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040 RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248 ko00000,ko00001,ko01000 - GH3 - Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C,PA14 k59_628688_1 985255.APHJ01000020_gene780 1.01e-48 179.0 COG1345@1|root,COG3209@1|root,COG1345@2|Bacteria,COG3209@2|Bacteria,4PKBQ@976|Bacteroidetes,1IJ6N@117743|Flavobacteriia 976|Bacteroidetes M SprB repeat - - - - - - - - - - - - CHU_C,Laminin_G_3,SprB k59_1588894_1 1260251.SPISAL_03470 3.34e-98 305.0 COG0556@1|root,COG0556@2|Bacteria,1MUFK@1224|Proteobacteria,1RN6Z@1236|Gammaproteobacteria,1WW4U@135613|Chromatiales 135613|Chromatiales L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage uvrB - - ko:K03702 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - Helicase_C,ResIII,UVR,UvrB k59_1476616_1 158500.BV97_02718 3.08e-48 169.0 2AXEK@1|root,31PDZ@2|Bacteria,1RADG@1224|Proteobacteria,2U5IY@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Replication protein C N-terminal domain - - - - - - - - - - - - RP-C k59_1476622_1 1197477.IA57_06750 3.98e-47 153.0 COG0537@1|root,COG0537@2|Bacteria,4NQ4X@976|Bacteroidetes,1I1YY@117743|Flavobacteriia 976|Bacteroidetes FG HIT family hinT - - ko:K02503 - - - - ko00000,ko04147 - - - HIT k59_1476622_2 391603.FBALC1_01442 2.43e-85 254.0 COG0782@1|root,COG0782@2|Bacteria,4NNH6@976|Bacteroidetes,1I18I@117743|Flavobacteriia 976|Bacteroidetes K Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides greA - - ko:K03624 - - - - ko00000,ko03021 - - - GreA_GreB,GreA_GreB_N k59_967594_1 436308.Nmar_0183 1.68e-45 149.0 COG1622@1|root,arCOG01236@2157|Archaea,41SMY@651137|Thaumarchaeota 651137|Thaumarchaeota C Heme copper-type cytochrome quinol oxidases, subunit 2 - - 1.9.3.1 ko:K02275 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.4,3.D.4.6 - - COX2 k59_967594_2 436308.Nmar_0182 3.83e-42 139.0 arCOG08824@1|root,arCOG08824@2157|Archaea,41SW7@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1025037_1 1056820.KB900663_gene3758 9.78e-54 194.0 COG1391@1|root,COG1391@2|Bacteria,1MU4I@1224|Proteobacteria,1RP9N@1236|Gammaproteobacteria,2PMWX@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria OT Glutamate-ammonia ligase adenylyltransferase glnE GO:0000166,GO:0000287,GO:0000820,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006521,GO:0006541,GO:0006542,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0008882,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0010565,GO:0016053,GO:0016740,GO:0016772,GO:0016779,GO:0017076,GO:0019222,GO:0019752,GO:0030554,GO:0031323,GO:0032553,GO:0032555,GO:0032559,GO:0033238,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046872,GO:0050789,GO:0050794,GO:0051171,GO:0062012,GO:0065007,GO:0070566,GO:0071704,GO:0080090,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.7.42,2.7.7.89 ko:K00982 - - - - ko00000,ko01000 - - - GlnD_UR_UTase,GlnE k59_1701987_1 1121106.JQKB01000142_gene4032 1.24e-82 260.0 COG3039@1|root,COG3039@2|Bacteria,1MVDK@1224|Proteobacteria,2U401@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Transposase - - - ko:K07481 - - - - ko00000 - - - DDE_Tnp_1,DUF772 k59_1476638_1 436308.Nmar_0832 3.21e-90 276.0 COG1253@1|root,arCOG00626@2157|Archaea,41T1G@651137|Thaumarchaeota 651137|Thaumarchaeota S Transporter associated domain - - - - - - - - - - - - CBS,CorC_HlyC,DUF21 k59_1419507_1 1411685.U062_01896 1.53e-23 99.8 COG1295@1|root,COG1295@2|Bacteria,1QICW@1224|Proteobacteria,1RMKI@1236|Gammaproteobacteria,1J640@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Virulence factor BrkB rbn GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K07058 - - - - ko00000 - - - Virul_fac_BrkB k59_1419507_2 498211.CJA_2283 3.27e-36 125.0 COG1393@1|root,COG1393@2|Bacteria,1MZ4Z@1224|Proteobacteria,1S8XH@1236|Gammaproteobacteria,1FHHN@10|Cellvibrio 1236|Gammaproteobacteria P ArsC family arsC GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 1.20.4.1 ko:K00537 - - - - ko00000,ko01000 - - - ArsC k59_628729_1 1415778.JQMM01000001_gene627 2.25e-90 273.0 COG0583@1|root,COG0583@2|Bacteria,1MVA1@1224|Proteobacteria,1RPAJ@1236|Gammaproteobacteria,1J4UM@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria K transcriptional regulator oxyR - - ko:K04761 ko02026,map02026 - - - ko00000,ko00001,ko03000 - - - HTH_1,LysR_substrate k59_685121_1 1502724.FF80_01023 2.03e-70 220.0 COG2801@1|root,COG2801@2|Bacteria,1MVXQ@1224|Proteobacteria,2U0FG@28211|Alphaproteobacteria 28211|Alphaproteobacteria L COG2801 Transposase and inactivated derivatives - - - ko:K07497 - - - - ko00000 - - - HTH_21,rve,rve_3 k59_1363467_1 388051.AUFE01000023_gene4544 7.86e-137 398.0 COG2197@1|root,COG2267@1|root,COG2197@2|Bacteria,COG2267@2|Bacteria,1QYHB@1224|Proteobacteria,2W1S8@28216|Betaproteobacteria,1K5IY@119060|Burkholderiaceae 28216|Betaproteobacteria K helix_turn_helix, Lux Regulon - - - - - - - - - - - - Abhydrolase_1,GerE k59_1025056_1 1049564.TevJSym_ca00050 4.66e-83 275.0 COG1033@1|root,COG2834@1|root,COG1033@2|Bacteria,COG2834@2|Bacteria,1MUE1@1224|Proteobacteria,1RPIP@1236|Gammaproteobacteria,1J96Q@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M MMPL family VP1286 - - ko:K07003 - - - - ko00000 - - - MMPL k59_459393_1 396588.Tgr7_2020 1.64e-45 157.0 COG0760@1|root,COG0760@2|Bacteria,1MZDK@1224|Proteobacteria,1S3VR@1236|Gammaproteobacteria,1X2I5@135613|Chromatiales 135613|Chromatiales M peptidylprolyl isomerase - - 5.2.1.8 ko:K03769 - - - - ko00000,ko01000,ko03110 - - - Rotamase_3 k59_911528_1 1229909.NSED_03040 9.79e-102 309.0 COG1384@1|root,arCOG00485@2157|Archaea,41SB4@651137|Thaumarchaeota 651137|Thaumarchaeota J Belongs to the class-I aminoacyl-tRNA synthetase family lysS - 6.1.1.6 ko:K04566 ko00970,map00970 M00360 R03658 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_1f k59_1476649_1 1229909.NSED_03435 1.48e-126 364.0 COG1635@1|root,arCOG00574@2157|Archaea,41SDJ@651137|Thaumarchaeota 651137|Thaumarchaeota G Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur thi4 - - ko:K03146 ko00730,ko01100,map00730,map01100 - R10685 RC00033,RC03253,RC03254 ko00000,ko00001 - - - Thi4 k59_1363481_1 316407.85675923 3.44e-38 133.0 COG3836@1|root,COG3836@2|Bacteria,1MUSG@1224|Proteobacteria,1RMWJ@1236|Gammaproteobacteria,3XMGU@561|Escherichia 1236|Gammaproteobacteria G Catalyzes the reversible retro-aldol cleavage of both 5- keto-4-deoxy-D-glucarate and 2-keto-3-deoxy-D-glucarate to pyruvate and tartronic semialdehyde garL GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0006082,GO:0008150,GO:0008152,GO:0008672,GO:0009056,GO:0009987,GO:0016052,GO:0016054,GO:0016829,GO:0016830,GO:0016832,GO:0017144,GO:0019392,GO:0019394,GO:0019577,GO:0019579,GO:0019580,GO:0019752,GO:0042737,GO:0042836,GO:0042838,GO:0043436,GO:0043648,GO:0043649,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044464,GO:0046392,GO:0046395,GO:0071704,GO:1901575 4.1.2.20 ko:K01630 ko00053,map00053 - R02754,R03277 RC00307,RC00435 ko00000,ko00001,ko01000 - - iAPECO1_1312.APECO1_3301,iE2348C_1286.E2348C_3412,iEC042_1314.EC042_3416,iEC55989_1330.EC55989_3544,iECIAI1_1343.ECIAI1_3274,iECIAI39_1322.ECIAI39_3625,iECNA114_1301.ECNA114_3207,iECO103_1326.ECO103_3871,iECO26_1355.ECO26_4229,iECOK1_1307.ECOK1_3549,iECP_1309.ECP_3216,iECS88_1305.ECS88_3514,iECSE_1348.ECSE_3410,iECSF_1327.ECSF_2962,iECUMN_1333.ECUMN_3608,iECW_1372.ECW_m3394,iECs_1301.ECs4004,iEKO11_1354.EKO11_0593,iEcE24377_1341.EcE24377A_3604,iEcSMS35_1347.EcSMS35_3421,iG2583_1286.G2583_3848,iLF82_1304.LF82_0805,iNRG857_1313.NRG857_15525,iSBO_1134.SBO_2991,iUMN146_1321.UM146_00720,iUTI89_1310.UTI89_C3557,iWFL_1372.ECW_m3394,iZ_1308.Z4478 HpcH_HpaI k59_1363481_2 316407.85675924 2.79e-68 218.0 COG2271@1|root,COG2271@2|Bacteria,1MVPS@1224|Proteobacteria,1RNMV@1236|Gammaproteobacteria,3XNY3@561|Escherichia 1236|Gammaproteobacteria P galactarate transporter garP GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0015711,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0044425,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944 - ko:K03535,ko:K08194,ko:K12299 - - - - ko00000,ko02000 2.A.1.14.1,2.A.1.14.14,2.A.1.14.7 - iECO103_1326.ECO103_4467,iSF_1195.SF3164,iSFxv_1172.SFxv_3474,iSSON_1240.SSON_2946,iS_1188.S3379 MFS_1 k59_64594_2 1229909.NSED_06270 2.22e-78 248.0 COG0028@1|root,arCOG01998@2157|Archaea,41S63@651137|Thaumarchaeota 651137|Thaumarchaeota E TIGRFAM acetolactate synthase, large subunit, biosynthetic type - - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_1646109_1 232346.JHQL01000001_gene2201 1.18e-65 218.0 COG2072@1|root,COG2072@2|Bacteria,1MWPJ@1224|Proteobacteria,1RQW4@1236|Gammaproteobacteria,1XN2J@135619|Oceanospirillales 135619|Oceanospirillales P Flavin-binding monooxygenase-like - - - ko:K07222 - - - - ko00000 - - - Pyr_redox_3 k59_290405_1 436308.Nmar_0651 1.38e-100 320.0 COG1196@1|root,arCOG00371@2157|Archaea,41SDS@651137|Thaumarchaeota 651137|Thaumarchaeota D SMC proteins Flexible Hinge Domain - - - ko:K03529 - - - - ko00000,ko03036 - - - SMC_N,SMC_hinge k59_233214_1 330214.NIDE4267 1.31e-70 220.0 COG3794@1|root,COG3794@2|Bacteria 2|Bacteria C PFAM blue (type 1) copper domain protein - - - - - - - - - - - - CarboxypepD_reg,fn3_3 k59_233214_2 330214.NIDE3936 1.75e-27 107.0 COG3794@1|root,COG3794@2|Bacteria 2|Bacteria C PFAM blue (type 1) copper domain protein - - - - - - - - - - - - CarboxypepD_reg,fn3_3 k59_459412_1 377629.TERTU_1782 1.02e-09 59.3 COG2963@1|root,COG2963@2|Bacteria,1N1CG@1224|Proteobacteria 1224|Proteobacteria L Transposase - - - ko:K07483 - - - - ko00000 - - - HTH_Tnp_1 k59_1588918_1 1033802.SSPSH_002810 1.51e-06 49.3 COG0053@1|root,COG0053@2|Bacteria,1MVH8@1224|Proteobacteria,1RQ3E@1236|Gammaproteobacteria 1236|Gammaproteobacteria P Co Zn Cd cation transporters catA - - - - - - - - - - - Cation_efflux,ZT_dimer k59_1588918_2 765911.Thivi_0735 1.27e-61 203.0 COG3174@1|root,COG3174@2|Bacteria,1NDBI@1224|Proteobacteria,1RRGY@1236|Gammaproteobacteria,1WVVW@135613|Chromatiales 135613|Chromatiales S Domain of unknown function (DUF4010) - - - - - - - - - - - - DUF4010,MgtC k59_290414_1 1122194.AUHU01000010_gene3111 2.6e-103 316.0 COG1069@1|root,COG1069@2|Bacteria,1MY11@1224|Proteobacteria,1RP3F@1236|Gammaproteobacteria,4662E@72275|Alteromonadaceae 1236|Gammaproteobacteria G FGGY family of carbohydrate kinases, N-terminal domain araB GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0005996,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008741,GO:0009056,GO:0009058,GO:0009987,GO:0016052,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019200,GO:0019321,GO:0019323,GO:0019566,GO:0019568,GO:0019569,GO:0019572,GO:0019637,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0044424,GO:0044464,GO:0046365,GO:0046373,GO:0046835,GO:0051167,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901159,GO:1901575,GO:1901576 2.7.1.16 ko:K00853 ko00040,ko01100,map00040,map01100 - R01526,R02439 RC00002,RC00538 ko00000,ko00001,ko01000 - - iBWG_1329.BWG_0059,iECH74115_1262.ECH74115_0068,iECSP_1301.ECSP_0067,iECs_1301.ECs0067,iG2583_1286.G2583_0066,iPC815.YPO2254,iZ_1308.Z0072 FGGY_C,FGGY_N k59_1646120_1 323848.Nmul_A0948 2.44e-93 305.0 COG3127@1|root,COG3127@2|Bacteria,1MU9R@1224|Proteobacteria,2VHHQ@28216|Betaproteobacteria,37208@32003|Nitrosomonadales 28216|Betaproteobacteria Q ABC-type transport system involved in lysophospholipase L1 biosynthesis permease component - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_402843_1 1229909.NSED_00570 5.88e-236 651.0 COG0136@1|root,arCOG00494@2157|Archaea,41SFD@651137|Thaumarchaeota 651137|Thaumarchaeota E aspartate-semialdehyde dehydrogenase - - 1.2.1.11 ko:K00133 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00017,M00018,M00033,M00525,M00526,M00527 R02291 RC00684 ko00000,ko00001,ko00002,ko01000 - - - Semialdhyde_dh,Semialdhyde_dhC k59_1307110_1 436308.Nmar_1453 1.83e-195 551.0 COG1690@1|root,arCOG04246@2157|Archaea,41SE4@651137|Thaumarchaeota 651137|Thaumarchaeota S Belongs to the RtcB family rtcB - 6.5.1.3 ko:K14415 - - - - ko00000,ko01000,ko03016 - - - RtcB k59_967650_1 247634.GPB2148_1335 2.5e-91 286.0 COG4770@1|root,COG4770@2|Bacteria,1P6RE@1224|Proteobacteria,1RM95@1236|Gammaproteobacteria,1J4GW@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria I COG4770 Acetyl propionyl-CoA carboxylase, alpha subunit mccA - 6.4.1.4 ko:K01968 ko00280,ko01100,map00280,map01100 M00036 R04138 RC00367,RC00942 ko00000,ko00001,ko00002,ko01000 - - - Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2 k59_1307111_1 555793.WSK_2699 4.12e-103 311.0 COG1904@1|root,COG1904@2|Bacteria,1MVRI@1224|Proteobacteria,2TS93@28211|Alphaproteobacteria,2JZWP@204457|Sphingomonadales 204457|Sphingomonadales G glucuronate isomerase uxaC - 5.3.1.12 ko:K01812 ko00040,ko01100,map00040,map01100 M00061,M00631 R01482,R01983 RC00376 ko00000,ko00001,ko00002,ko01000 - - - UxaC k59_346926_1 1128421.JAGA01000002_gene695 7.4e-88 270.0 COG0050@1|root,COG0050@2|Bacteria,2NNQV@2323|unclassified Bacteria 2|Bacteria J This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis tuf - - ko:K02358 - - - - ko00000,ko03012,ko03029,ko04147 - - - GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3 k59_1250291_1 158500.BV97_03585 8.16e-55 181.0 COG1706@1|root,COG1706@2|Bacteria,1MVKW@1224|Proteobacteria,2TQNX@28211|Alphaproteobacteria,2K00I@204457|Sphingomonadales 204457|Sphingomonadales N Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation flgI - - ko:K02394 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - FlgI k59_1250291_2 1096930.L284_05355 8.73e-24 92.4 COG3951@1|root,COG3951@2|Bacteria,1NG9S@1224|Proteobacteria,2VCVQ@28211|Alphaproteobacteria,2K71S@204457|Sphingomonadales 204457|Sphingomonadales MNO Rod binding protein - - - - - - - - - - - - Rod-binding k59_1646134_1 382464.ABSI01000012_gene2200 5.99e-55 193.0 COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria 2|Bacteria S cAMP biosynthetic process - - - - - - - - - - - - BTAD,TPR_11,TPR_16,TPR_7,TPR_8,Trans_reg_C k59_7798_3 1242864.D187_005699 2.21e-67 233.0 COG2114@1|root,COG3899@1|root,COG2114@2|Bacteria,COG3899@2|Bacteria,1MUDT@1224|Proteobacteria,42NXT@68525|delta/epsilon subdivisions,2WIZ3@28221|Deltaproteobacteria,2YU18@29|Myxococcales 28221|Deltaproteobacteria KLT Adenylyl- / guanylyl cyclase, catalytic domain - - - - - - - - - - - - AAA_16,Guanylate_cyc,Pkinase k59_346943_1 1122137.AQXF01000002_gene431 1.82e-43 152.0 COG0845@1|root,COG0845@2|Bacteria,1MUFW@1224|Proteobacteria,2U2CU@28211|Alphaproteobacteria 28211|Alphaproteobacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - ko:K03585 ko01501,ko01503,map01501,map01503 M00646,M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000,ko03036 2.A.6.2,8.A.1.6 - - HlyD_D23 k59_346943_2 1122137.AQXF01000002_gene432 7.35e-27 106.0 COG0583@1|root,COG0583@2|Bacteria,1R7RW@1224|Proteobacteria,2U8Q9@28211|Alphaproteobacteria 28211|Alphaproteobacteria K Transcriptional regulator - - - - - - - - - - - - HTH_1,LysR_substrate k59_402885_1 1298593.TOL_0092 2.54e-20 91.7 COG4774@1|root,COG4774@2|Bacteria,1NMCN@1224|Proteobacteria,1T239@1236|Gammaproteobacteria,1XRZ0@135619|Oceanospirillales 135619|Oceanospirillales P TonB dependent receptor - - - - - - - - - - - - Plug,TonB_dep_Rec k59_1250310_1 1415778.JQMM01000001_gene750 1.02e-61 206.0 COG1538@1|root,COG1538@2|Bacteria,1MWCJ@1224|Proteobacteria,1RQQV@1236|Gammaproteobacteria,1J52S@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria MU COG1538 Outer membrane protein tolC - - ko:K12340 ko01501,ko01503,ko02020,ko03070,ko04626,ko05133,map01501,map01503,map02020,map03070,map04626,map05133 M00325,M00326,M00339,M00571,M00575,M00646,M00647,M00696,M00697,M00709,M00720,M00821 - - ko00000,ko00001,ko00002,ko01504,ko02000,ko02044 1.B.17,2.A.6.2 - - OEP k59_1702046_1 864051.BurJ1DRAFT_1716 1.6e-59 204.0 COG0525@1|root,COG0525@2|Bacteria,1MV7B@1224|Proteobacteria,2VH5Z@28216|Betaproteobacteria,1KJN2@119065|unclassified Burkholderiales 28216|Betaproteobacteria J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner valS - 6.1.1.9 ko:K01873 ko00970,map00970 M00359,M00360 R03665 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1 k59_1025120_1 411684.HPDFL43_00110 1.71e-38 130.0 COG1396@1|root,COG1396@2|Bacteria 2|Bacteria K sequence-specific DNA binding - - - - - - - - - - - - HTH_3,HTH_37 k59_1080790_1 1144307.PMI04_01389 1.46e-96 288.0 COG0583@1|root,COG0583@2|Bacteria,1MU7H@1224|Proteobacteria,2TS72@28211|Alphaproteobacteria,2K1X2@204457|Sphingomonadales 204457|Sphingomonadales K Transcriptional regulator - - - - - - - - - - - - HTH_1,LysR_substrate k59_1646168_1 351348.Maqu_3729 8.42e-23 100.0 COG3520@1|root,COG3520@2|Bacteria,1MWVS@1224|Proteobacteria,1RQD5@1236|Gammaproteobacteria,468RQ@72275|Alteromonadaceae 1236|Gammaproteobacteria S protein conserved in bacteria impH - - ko:K11895 ko02025,map02025 M00334 - - ko00000,ko00001,ko00002,ko02044 3.A.23.1 - - T6SS_TssG k59_130967_1 935863.AWZR01000014_gene2976 8.04e-71 231.0 COG3420@1|root,COG3420@2|Bacteria,1NNDG@1224|Proteobacteria,1SZ6G@1236|Gammaproteobacteria 1236|Gammaproteobacteria P Periplasmic copper-binding protein (NosD) - - - - - - - - - - - - Beta_helix k59_1543506_1 323261.Noc_0240 5.35e-56 184.0 COG4535@1|root,COG4535@2|Bacteria,1QTU8@1224|Proteobacteria,1RMKX@1236|Gammaproteobacteria,1WW4G@135613|Chromatiales 135613|Chromatiales P PFAM CBS domain - - - ko:K06189 - - - - ko00000,ko02000 9.A.40.1.2 - - CBS,CorC_HlyC k59_1204270_1 81985.XP_006279602.1 3.41e-136 407.0 COG1012@1|root,KOG2451@2759|Eukaryota,37KPW@33090|Viridiplantae,3GA3J@35493|Streptophyta,3HMPB@3699|Brassicales 35493|Streptophyta C Delta-1-pyrroline-5-carboxylate dehydrogenase 12A1 - GO:0003674,GO:0003824,GO:0003842,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0006082,GO:0006520,GO:0006536,GO:0006560,GO:0006562,GO:0006807,GO:0006950,GO:0006970,GO:0008150,GO:0008152,GO:0008270,GO:0009056,GO:0009063,GO:0009064,GO:0009065,GO:0009507,GO:0009536,GO:0009628,GO:0009651,GO:0009987,GO:0010133,GO:0016054,GO:0016491,GO:0016645,GO:0016646,GO:0019752,GO:0043167,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0046483,GO:0046700,GO:0046872,GO:0046914,GO:0050896,GO:0050897,GO:0055114,GO:0071704,GO:0072593,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 1.2.1.88 ko:K00294 ko00250,ko00330,ko01100,map00250,map00330,map01100 - R00245,R00707,R00708,R04444,R04445,R05051 RC00080,RC00216,RC00242,RC00255 ko00000,ko00001,ko01000 - - - Aldedh k59_1317641_1 1114970.PSF113_0819 1.54e-85 271.0 COG1233@1|root,COG1233@2|Bacteria,1MV2R@1224|Proteobacteria,1RSGI@1236|Gammaproteobacteria 1236|Gammaproteobacteria Q COG1233 Phytoene dehydrogenase and related proteins - - - - - - - - - - - - Amino_oxidase,DAO,NAD_binding_8 k59_1147452_1 316407.85675733 4.27e-85 255.0 COG2968@1|root,COG2968@2|Bacteria,1RH7T@1224|Proteobacteria,1RP7T@1236|Gammaproteobacteria,3XNCG@561|Escherichia 1236|Gammaproteobacteria S cellular response to heat yggE GO:0000302,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006950,GO:0006974,GO:0006979,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009897,GO:0009986,GO:0009987,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0031233,GO:0033554,GO:0034599,GO:0034605,GO:0034614,GO:0042221,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051716,GO:0070887,GO:0071575,GO:0071944,GO:0098552,GO:1901700,GO:1901701 - ko:K09807 - - - - ko00000 - - - SIMPL k59_187874_1 1288494.EBAPG3_29150 5.11e-69 216.0 COG0356@1|root,COG0356@2|Bacteria,1MV87@1224|Proteobacteria,2VHR5@28216|Betaproteobacteria,371W5@32003|Nitrosomonadales 28216|Betaproteobacteria C it plays a direct role in the translocation of protons across the membrane atpB - - ko:K02108 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko03110 3.A.2.1 - - ATP-synt_A k59_187874_2 323848.Nmul_A0303 7.18e-16 73.9 COG3312@1|root,COG3312@2|Bacteria,1NQF1@1224|Proteobacteria,2W4BE@28216|Betaproteobacteria,373BY@32003|Nitrosomonadales 28216|Betaproteobacteria C ATP synthase I chain - - - ko:K02116 - - - - ko00000,ko00194 3.A.2.1 - - ATP-synt_I k59_187875_2 391615.ABSJ01000057_gene1518 6.9e-30 117.0 COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,1RM93@1236|Gammaproteobacteria 1236|Gammaproteobacteria I Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed fadA - 2.3.1.16 ko:K00632 ko00071,ko00280,ko00281,ko00362,ko00592,ko00642,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00362,map00592,map00642,map01100,map01110,map01120,map01130,map01212 M00087,M00113 R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095 RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955 ko00000,ko00001,ko00002,ko01000 - - - Thiolase_C,Thiolase_N k59_75255_1 391615.ABSJ01000026_gene121 2.82e-79 250.0 2CIBN@1|root,2Z8JT@2|Bacteria,1R902@1224|Proteobacteria,1RXPM@1236|Gammaproteobacteria,1J8X1@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Metal dependent phosphohydrolases with conserved 'HD' motif. - - - - - - - - - - - - - k59_301052_1 795359.TOPB45_0757 5.01e-26 97.8 COG0185@1|root,COG0185@2|Bacteria,2GHZ4@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria J Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA rpsS - - ko:K02965 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S19 k59_301052_2 1196083.SALWKB12_1427 8.43e-49 163.0 COG0090@1|root,COG0090@2|Bacteria,1MVTD@1224|Proteobacteria,2VHSD@28216|Betaproteobacteria,2KPKG@206351|Neisseriales 206351|Neisseriales J One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity rplB - - ko:K02886 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L2,Ribosomal_L2_C k59_1204287_1 382464.ABSI01000011_gene2783 3.18e-95 289.0 COG2730@1|root,COG2730@2|Bacteria,46US1@74201|Verrucomicrobia 74201|Verrucomicrobia G Belongs to the glycosyl hydrolase 5 (cellulase A) family - - - - - - - - - - - - Cellulase k59_301065_1 1380386.JIAW01000010_gene4109 1.2e-79 255.0 COG2072@1|root,COG2072@2|Bacteria,2GKYU@201174|Actinobacteria,234M3@1762|Mycobacteriaceae 201174|Actinobacteria P flavoprotein involved in K transport - - 1.14.13.22 ko:K03379 ko00930,ko01120,ko01220,map00930,map01120,map01220 - R02231,R06622 RC00662,RC01550 ko00000,ko00001,ko01000 - - - FMO-like,NAD_binding_8,Pyr_redox_2,Pyr_redox_3 k59_809166_1 926569.ANT_05220 6.39e-23 98.6 COG0405@1|root,COG0405@2|Bacteria,2G5R2@200795|Chloroflexi 200795|Chloroflexi E PFAM Gamma-glutamyltranspeptidase - - 2.3.2.2,3.4.19.13 ko:K00681 ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100 - R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935 RC00064,RC00090,RC00096 ko00000,ko00001,ko01000,ko01002 - - - G_glu_transpept k59_809166_2 314230.DSM3645_19883 9.46e-62 206.0 COG0069@1|root,COG0069@2|Bacteria,2J28V@203682|Planctomycetes 203682|Planctomycetes E Belongs to the glutamate synthase family - - 2.1.1.21 ko:K22083 ko00680,ko01120,map00680,map01120 - R01586 RC00554 ko00000,ko00001,ko01000 - - - Glu_synthase k59_752111_1 266264.Rmet_5178 3.48e-60 192.0 COG0265@1|root,COG0265@2|Bacteria,1R40X@1224|Proteobacteria,2VMJD@28216|Betaproteobacteria,1K51P@119060|Burkholderiaceae 28216|Betaproteobacteria O Trypsin-like peptidase domain - - - - - - - - - - - - Trypsin_2 k59_469672_1 983545.Glaag_3057 2.09e-49 182.0 COG1404@1|root,COG1404@2|Bacteria,1MVJE@1224|Proteobacteria,1RQ2M@1236|Gammaproteobacteria,4683H@72275|Alteromonadaceae 1236|Gammaproteobacteria O Peptidase inhibitor I9 - - - - - - - - - - - - Inhibitor_I9,PA,Peptidase_S8 k59_1147475_1 32042.PstZobell_16059 1.06e-21 97.8 COG2211@1|root,COG2211@2|Bacteria,1MVUM@1224|Proteobacteria,1RP5J@1236|Gammaproteobacteria,1Z0HS@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria G Na melibiose symporter and related - - - - - - - - - - - - MFS_2 k59_866119_1 246197.MXAN_3650 3.95e-12 71.2 COG0577@1|root,COG0577@2|Bacteria,1PIKV@1224|Proteobacteria 1224|Proteobacteria V ABC-type antimicrobial peptide transport system, permease component - - - - - - - - - - - - FtsX,MacB_PCD k59_1260439_1 1209072.ALBT01000007_gene2781 3.59e-26 112.0 COG2931@1|root,COG2982@1|root,COG4733@1|root,COG4932@1|root,COG2931@2|Bacteria,COG2982@2|Bacteria,COG4733@2|Bacteria,COG4932@2|Bacteria,1MU7T@1224|Proteobacteria,1RNK8@1236|Gammaproteobacteria 1236|Gammaproteobacteria Q COG2931 RTX toxins and related Ca2 -binding proteins - - - ko:K11005 - - - - ko00000,ko02000,ko02042 1.C.11 - - Cadherin_3,Calx-beta,He_PIG,HemolysinCabind,VWA_2 k59_1204294_2 1168065.DOK_16878 2.67e-28 111.0 COG0762@1|root,COG0762@2|Bacteria,1RCZV@1224|Proteobacteria,1S6DW@1236|Gammaproteobacteria,1J6HX@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S integral membrane protein yggT GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K02221 - - - - ko00000,ko02044 - - - YGGT k59_525623_2 511.JT27_14935 5.9e-83 257.0 COG2309@1|root,COG2309@2|Bacteria,1R4JS@1224|Proteobacteria,2VITA@28216|Betaproteobacteria,3T6H6@506|Alcaligenaceae 28216|Betaproteobacteria E leucyl aminopeptidase, aminopeptidase T - - 1.13.11.9 ko:K18028 ko00760,ko01120,map00760,map01120 M00622 R09125 RC02430 ko00000,ko00001,ko00002,ko01000 - - - - k59_1429905_1 146922.JOFU01000027_gene1152 2.49e-72 246.0 COG3321@1|root,COG3321@2|Bacteria 2|Bacteria Q synthase - - - - - - - - - - - - ACPS,Acyl_transf_1,KAsynt_C_assoc,Ketoacyl-synt_C,PS-DH,ketoacyl-synt k59_187907_1 1137281.D778_01795 2.36e-96 288.0 COG0042@1|root,COG0042@2|Bacteria,4NEN4@976|Bacteroidetes,1HWK5@117743|Flavobacteriia 976|Bacteroidetes J Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines dus - - - - - - - - - - - Dus k59_18106_2 714083.JH370377_gene2716 3.75e-43 158.0 COG3845@1|root,COG3845@2|Bacteria,2H7KJ@201174|Actinobacteria,4FKR5@85023|Microbacteriaceae 201174|Actinobacteria S ATPases associated with a variety of cellular activities - - 3.6.3.17 ko:K02056 - M00221 - - ko00000,ko00002,ko01000,ko02000 3.A.1.2 - - ABC_tran k59_809207_2 1150469.RSPPHO_02753 4.96e-23 97.4 COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2TR7Q@28211|Alphaproteobacteria,2JQKF@204441|Rhodospirillales 204441|Rhodospirillales C III protein, CoA-transferase family - - 2.8.3.16 ko:K07749 - - - - ko00000,ko01000 - - - CoA_transf_3 k59_695671_1 1168034.FH5T_11765 5.76e-22 94.7 COG1426@1|root,COG1426@2|Bacteria 2|Bacteria S sequence-specific DNA binding - - - ko:K15539 - - - - ko00000 - - - DUF4115,HTH_25,HTH_3 k59_921760_1 1088721.NSU_0754 2.16e-214 604.0 COG5362@1|root,COG5362@2|Bacteria,1R90H@1224|Proteobacteria,2U236@28211|Alphaproteobacteria,2K93W@204457|Sphingomonadales 204457|Sphingomonadales S TIGRFAM Phage - - - - - - - - - - - - - k59_866158_1 589865.DaAHT2_1568 1.55e-43 163.0 COG5002@1|root,COG5002@2|Bacteria,1MWF3@1224|Proteobacteria,42NB5@68525|delta/epsilon subdivisions,2WJGX@28221|Deltaproteobacteria,2MI1J@213118|Desulfobacterales 28221|Deltaproteobacteria T histidine kinase HAMP region domain protein phoR - 2.7.13.3 ko:K07636 ko02020,map02020 M00434 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,HisKA,PAS,PAS_4,PAS_8,sCache_like k59_977324_1 1173027.Mic7113_2251 2.62e-25 110.0 COG2831@1|root,COG2831@2|Bacteria,1G03B@1117|Cyanobacteria,1H7Y8@1150|Oscillatoriales 1117|Cyanobacteria U Hemolysin activation secretion protein - - - - - - - - - - - - POTRA_2,ShlB k59_1769124_1 120017.I2G3U6 6.21e-15 75.9 COG1304@1|root,COG5274@1|root,KOG0537@2759|Eukaryota,KOG0538@2759|Eukaryota,39X9P@33154|Opisthokonta,3NYXS@4751|Fungi,3UZHV@5204|Basidiomycota,3N3SX@452284|Ustilaginomycotina 4751|Fungi C Conserved region in glutamate synthase - - 1.1.2.3 ko:K00101 ko00620,ko01100,map00620,map01100 - R00196 RC00044 ko00000,ko00001,ko01000 - - - Cyt-b5,FMN_dh,Glu_synthase k59_187951_1 702113.PP1Y_Mpl6736 5.56e-100 303.0 COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2TQR1@28211|Alphaproteobacteria,2JZVD@204457|Sphingomonadales 204457|Sphingomonadales C belongs to the aldehyde dehydrogenase family - - - - - - - - - - - - Aldedh k59_1656869_1 1049564.TevJSym_bb00130 2.39e-21 97.8 COG5009@1|root,COG5009@2|Bacteria,1MU5A@1224|Proteobacteria,1RM7J@1236|Gammaproteobacteria,1J4BX@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M penicillin-binding protein mrcA GO:0000270,GO:0003674,GO:0003824,GO:0004180,GO:0004185,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006022,GO:0006023,GO:0006024,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0008238,GO:0008360,GO:0008658,GO:0008955,GO:0009002,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016021,GO:0016740,GO:0016757,GO:0016758,GO:0016787,GO:0017171,GO:0019538,GO:0022603,GO:0022604,GO:0030203,GO:0031224,GO:0031226,GO:0031406,GO:0033218,GO:0033293,GO:0034645,GO:0036094,GO:0042221,GO:0042546,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044425,GO:0044459,GO:0044464,GO:0046677,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051128,GO:0065007,GO:0065008,GO:0070008,GO:0070011,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:0097159,GO:0140096,GO:1901135,GO:1901137,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901681 2.4.1.129,3.4.16.4 ko:K05366 ko00550,ko01100,ko01501,map00550,map01100,map01501 - - - ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 - PCB_OB,Transgly,Transpeptidase k59_639356_1 882378.RBRH_00943 3.39e-16 72.0 COG1278@1|root,COG1278@2|Bacteria,1N6Q5@1224|Proteobacteria,2VVTG@28216|Betaproteobacteria,1K9CX@119060|Burkholderiaceae 28216|Betaproteobacteria K Cold shock protein cspD - - ko:K03704 - - - - ko00000,ko03000 - - - CSD k59_752155_1 269799.Gmet_1426 3.63e-42 157.0 COG2844@1|root,COG2844@2|Bacteria,1MV54@1224|Proteobacteria,42MN5@68525|delta/epsilon subdivisions,2WINN@28221|Deltaproteobacteria,43SYQ@69541|Desulfuromonadales 28221|Deltaproteobacteria H Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism glnD - 2.7.7.59 ko:K00990 ko02020,map02020 - - - ko00000,ko00001,ko01000 - - - ACT,DUF294,GlnD_UR_UTase,GlnE,HD,NTP_transf_2 k59_525663_1 1192124.LIG30_3044 6.02e-10 62.8 2CESE@1|root,32S0D@2|Bacteria,1RHTD@1224|Proteobacteria,2VSJ5@28216|Betaproteobacteria,1K83E@119060|Burkholderiaceae 28216|Betaproteobacteria S Glycine-zipper domain - - - - - - - - - - - - Gly-zipper_OmpA,Gly-zipper_YMGG k59_525663_2 1198232.CYCME_2436 1.1e-11 67.0 COG0741@1|root,COG1388@1|root,COG0741@2|Bacteria,COG1388@2|Bacteria,1MWKE@1224|Proteobacteria,1RMFZ@1236|Gammaproteobacteria 1236|Gammaproteobacteria M COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains) mltD - - ko:K08307 - - - - ko00000,ko01000,ko01011 - - - LysM,SLT k59_1429949_1 1437882.AZRU01000025_gene5857 1.58e-46 155.0 COG0778@1|root,COG0778@2|Bacteria,1MZN8@1224|Proteobacteria,1RPVA@1236|Gammaproteobacteria,1YD6B@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria C Cob(II)yrinic acid a,c-diamide reductase bluB - 1.13.11.79 ko:K04719 ko00740,ko01100,map00740,map01100 - R09083 RC00435,RC02413 ko00000,ko00001,ko01000 - - - Nitroreductase k59_1429949_2 1122194.AUHU01000005_gene984 1.05e-22 94.7 COG0614@1|root,COG0614@2|Bacteria,1MWVF@1224|Proteobacteria,1RMV8@1236|Gammaproteobacteria,466A4@72275|Alteromonadaceae 1236|Gammaproteobacteria P COG0614 ABC-type Fe3 -hydroxamate transport system, periplasmic component btuF GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0006810,GO:0008144,GO:0008150,GO:0015889,GO:0015893,GO:0019842,GO:0030288,GO:0030313,GO:0031419,GO:0031975,GO:0036094,GO:0042221,GO:0042493,GO:0042597,GO:0044464,GO:0046906,GO:0048037,GO:0050896,GO:0051179,GO:0051180,GO:0051181,GO:0051234,GO:0071702,GO:0071705,GO:0097159,GO:1901363 - ko:K02016,ko:K06858 ko02010,map02010 M00240,M00241 - - ko00000,ko00001,ko00002,ko02000 3.A.1.13,3.A.1.14 - iECH74115_1262.ECH74115_0168,iECSP_1301.ECSP_0159,iECs_1301.ECs0162,iZ_1308.Z0169 Peripla_BP_2 k59_301129_1 314266.SKA58_12707 7.08e-115 335.0 COG0039@1|root,COG0039@2|Bacteria,1MV57@1224|Proteobacteria,2TSV6@28211|Alphaproteobacteria,2K17I@204457|Sphingomonadales 204457|Sphingomonadales C Catalyzes the reversible oxidation of malate to oxaloacetate mdh - 1.1.1.37 ko:K00024 ko00020,ko00270,ko00620,ko00630,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00270,map00620,map00630,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740 R00342,R07136 RC00031 ko00000,ko00001,ko00002,ko01000 - - - Ldh_1_C,Ldh_1_N k59_977340_1 768671.ThimaDRAFT_2966 1.66e-71 238.0 COG1331@1|root,COG1331@2|Bacteria,1MUUT@1224|Proteobacteria,1RSQQ@1236|Gammaproteobacteria,1WWA4@135613|Chromatiales 135613|Chromatiales O Protein of unknown function, DUF255 - - - ko:K06888 - - - - ko00000 - - - Thioredox_DsbH k59_413225_1 1191523.MROS_0107 6.24e-42 155.0 COG3420@1|root,COG3420@2|Bacteria 2|Bacteria P alginic acid biosynthetic process algG - 5.1.3.37 ko:K01795 ko00051,map00051 - R08693 RC00509 ko00000,ko00001,ko01000 - - - Beta_helix,DUF1565,NosD k59_18154_1 1122137.AQXF01000006_gene788 4.9e-246 689.0 COG0129@1|root,COG0129@2|Bacteria,1MUTQ@1224|Proteobacteria,2TRTQ@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Belongs to the IlvD Edd family ilvD - 4.2.1.9 ko:K01687 ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R01209,R04441,R05070 RC00468,RC01714 ko00000,ko00001,ko00002,ko01000 - - - ILVD_EDD k59_752171_1 247639.MGP2080_12048 6.7e-32 129.0 COG1757@1|root,COG1757@2|Bacteria,1MY5C@1224|Proteobacteria,1RP6I@1236|Gammaproteobacteria,1J88H@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C COG1757 Na H antiporter - - - - - - - - - - - - Na_H_antiporter k59_809264_1 666685.R2APBS1_3029 2.11e-50 167.0 COG0742@1|root,COG0742@2|Bacteria,1MXKW@1224|Proteobacteria,1RN21@1236|Gammaproteobacteria,1X6P7@135614|Xanthomonadales 135614|Xanthomonadales L Specifically methylates the guanine in position 966 of 16S rRNA in the assembled 30S particle - - 2.1.1.171 ko:K08316 - - R07234 RC00003 ko00000,ko01000,ko03009 - - - Cons_hypoth95 k59_809264_2 519989.ECTPHS_06612 2.46e-118 356.0 COG0552@1|root,COG0552@2|Bacteria,1MUDU@1224|Proteobacteria,1RNIN@1236|Gammaproteobacteria,1WW5G@135613|Chromatiales 135613|Chromatiales U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components ftsY - - ko:K03110 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2,3.A.5.7 - - SRP54,SRP54_N k59_809264_3 876044.IMCC3088_2187 2.59e-87 264.0 COG2884@1|root,COG2884@2|Bacteria,1MVQ4@1224|Proteobacteria,1RMZA@1236|Gammaproteobacteria 1236|Gammaproteobacteria D cell division ATP-binding protein FtsE ftsE GO:0000166,GO:0003674,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0008144,GO:0008150,GO:0009898,GO:0009987,GO:0016020,GO:0017076,GO:0019897,GO:0019898,GO:0030554,GO:0031234,GO:0032153,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042221,GO:0043167,GO:0043168,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0046677,GO:0050896,GO:0051301,GO:0071944,GO:0097159,GO:0097367,GO:0098552,GO:0098562,GO:1901265,GO:1901363 - ko:K09812 ko02010,map02010 M00256 - - ko00000,ko00001,ko00002,ko02000,ko03036 3.A.1.140 - - ABC_tran k59_866196_1 1198452.Jab_2c08800 2.92e-22 100.0 COG4251@1|root,COG4251@2|Bacteria,1NSQ1@1224|Proteobacteria 1224|Proteobacteria T Histidine kinase - - 2.7.13.3 ko:K20974 ko02020,ko02025,map02020,map02025 M00820 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,HisKA,Hpt,PAS_3,PAS_4,Response_reg,SBP_bac_3,dCache_1 k59_75333_1 1096930.L284_04480 2.21e-79 257.0 COG0855@1|root,COG0855@2|Bacteria,1MUM3@1224|Proteobacteria,2TRBP@28211|Alphaproteobacteria,2K167@204457|Sphingomonadales 204457|Sphingomonadales P Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) ppk - 2.7.4.1 ko:K00937 ko00190,ko03018,map00190,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - PP_kinase,PP_kinase_C,PP_kinase_N k59_1769182_1 748658.KB907312_gene1698 2.59e-13 74.7 COG4425@1|root,COG4425@2|Bacteria,1MXSU@1224|Proteobacteria,1RYFH@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Alpha/beta-hydrolase family N-terminus - - - - - - - - - - - - Abhydrolase_9,Abhydrolase_9_N k59_752176_1 1122194.AUHU01000006_gene532 1.71e-123 368.0 COG4225@1|root,COG4225@2|Bacteria,1NIRN@1224|Proteobacteria,1S2HX@1236|Gammaproteobacteria,467YP@72275|Alteromonadaceae 1236|Gammaproteobacteria S BNR repeat-containing family member - - - - - - - - - - - - BNR_4 k59_1374295_1 1117647.M5M_10885 6.49e-129 383.0 COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,1RR00@1236|Gammaproteobacteria,1J5GX@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria EH Thiamine pyrophosphate enzyme, C-terminal TPP binding domain alsS - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_1487593_1 1288494.EBAPG3_10730 9.35e-74 228.0 COG2928@1|root,COG2928@2|Bacteria,1MWT5@1224|Proteobacteria,2VH65@28216|Betaproteobacteria,372E4@32003|Nitrosomonadales 28216|Betaproteobacteria S Protein of unknown function (DUF502) - - - - - - - - - - - - DUF502 k59_1092227_2 95619.PM1_0219205 5.92e-69 218.0 COG0123@1|root,COG0123@2|Bacteria,1MU7P@1224|Proteobacteria,1S070@1236|Gammaproteobacteria 1236|Gammaproteobacteria BQ COG0123 Deacetylases, including yeast histone deacetylase and acetoin utilization protein - - - - - - - - - - - - Hist_deacetyl k59_867251_1 765914.ThisiDRAFT_1590 3.39e-68 226.0 COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,1RPCU@1236|Gammaproteobacteria,1WWF4@135613|Chromatiales 135613|Chromatiales S ABC transporter - - - ko:K15738 - - - - ko00000,ko02000 3.A.1.120.6 - - ABC_tran,ABC_tran_CTD,ABC_tran_Xtn k59_302211_1 497321.C664_16790 4.14e-25 100.0 COG1191@1|root,COG1191@2|Bacteria,1MWEU@1224|Proteobacteria,2VHR3@28216|Betaproteobacteria,2KUVX@206389|Rhodocyclales 206389|Rhodocyclales K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor controls the expression of flagella-related genes fliA - - ko:K02405 ko02020,ko02025,ko02026,ko02040,ko05111,map02020,map02025,map02026,map02040,map05111 - - - ko00000,ko00001,ko02035,ko03021 - - - Sigma70_r2,Sigma70_r3,Sigma70_r4 k59_302211_2 399739.Pmen_2804 4.03e-44 146.0 COG0745@1|root,COG0745@2|Bacteria,1RDNP@1224|Proteobacteria,1S47I@1236|Gammaproteobacteria,1YFTG@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria KT Response regulator receiver domain cheY - - ko:K03413 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko02022,ko02035 - - - Response_reg k59_1770322_1 1121403.AUCV01000053_gene2642 5.99e-66 237.0 COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42PJW@68525|delta/epsilon subdivisions,2WJQ3@28221|Deltaproteobacteria,2MPRM@213118|Desulfobacterales 28221|Deltaproteobacteria T Bacterial periplasmic substrate-binding proteins - - - - - - - - - - - - HATPase_c,HisKA,PAS_3,PAS_4,PAS_9,Response_reg,SBP_bac_3 k59_526711_1 1535422.ND16A_2166 7.15e-07 58.9 COG0358@1|root,COG0358@2|Bacteria,1MUHC@1224|Proteobacteria,1RMGA@1236|Gammaproteobacteria,2Q65W@267889|Colwelliaceae 1236|Gammaproteobacteria L DNA primase DnaG DnaB-binding dnaG - - ko:K02316 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB_bind,DnaG_DnaB_bind,Toprim_2,Toprim_4,Toprim_N,zf-CHC2 k59_526711_2 404589.Anae109_0762 2.06e-157 479.0 COG0568@1|root,COG0568@2|Bacteria,1MVNJ@1224|Proteobacteria,42N2S@68525|delta/epsilon subdivisions,2WJ0E@28221|Deltaproteobacteria,2YUHI@29|Myxococcales 28221|Deltaproteobacteria K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth rpoD - - ko:K03086 - - - - ko00000,ko03021 - - - Sigma70_ner,Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4 k59_302216_1 1229909.NSED_03795 8.11e-05 44.3 arCOG08801@1|root,arCOG08801@2157|Archaea 2157|Archaea S Metal dependent phosphohydrolases with conserved 'HD' motif. - - - - - - - - - - - - - k59_302216_2 436308.Nmar_0889 3.73e-29 107.0 arCOG10559@1|root,arCOG10559@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_302216_4 1229909.NSED_04010 3.18e-40 137.0 arCOG08802@1|root,arCOG08802@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_1384503_1 926569.ANT_04670 1.36e-99 301.0 COG0498@1|root,COG0498@2|Bacteria,2G6D6@200795|Chloroflexi 200795|Chloroflexi E Pyridoxal-phosphate dependent enzyme - - 4.2.3.1 ko:K01733 ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230 M00018 R01466,R05086 RC00017,RC00526 ko00000,ko00001,ko00002,ko01000 - - - PALP k59_1776006_1 316407.85675365 5.74e-103 309.0 COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,1RNGU@1236|Gammaproteobacteria,3XMTM@561|Escherichia 1236|Gammaproteobacteria I Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed fadI GO:0003674,GO:0003824,GO:0003857,GO:0003988,GO:0004300,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016408,GO:0016491,GO:0016614,GO:0016616,GO:0016740,GO:0016746,GO:0016747,GO:0016829,GO:0016835,GO:0016836,GO:0019395,GO:0019752,GO:0030258,GO:0032787,GO:0033542,GO:0034440,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0055114,GO:0071704,GO:0072329,GO:1901575 2.3.1.16 ko:K00632 ko00071,ko00280,ko00281,ko00362,ko00592,ko00642,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00362,map00592,map00642,map01100,map01110,map01120,map01130,map01212 M00087,M00113 R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095 RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955 ko00000,ko00001,ko00002,ko01000 - - iECO103_1326.ECO103_2806,iEcHS_1320.EcHS_A2493 Thiolase_C,Thiolase_N k59_647086_1 555793.WSK_2719 6.21e-63 196.0 COG0864@1|root,COG0864@2|Bacteria,1RDN6@1224|Proteobacteria,2UIUA@28211|Alphaproteobacteria,2KDS6@204457|Sphingomonadales 204457|Sphingomonadales K Transcriptional regulator - - - ko:K07722 - - - - ko00000,ko03000 - - - NikR_C,RHH_1 k59_1046195_1 316057.RPD_2072 1.35e-32 132.0 COG2010@1|root,COG3258@1|root,COG2010@2|Bacteria,COG3258@2|Bacteria,1MV6D@1224|Proteobacteria,2TT9U@28211|Alphaproteobacteria,3JR14@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria C Cytochrome C oxidase, cbb3-type, subunit III - - 1.8.2.2 ko:K19713 - - - - ko00000,ko01000 - - - Cytochrom_C,Cytochrome_CBB3 k59_759761_2 1000565.METUNv1_02172 4.05e-12 65.1 COG3038@1|root,COG3038@2|Bacteria,1QHFX@1224|Proteobacteria,2VUUJ@28216|Betaproteobacteria,2KZ01@206389|Rhodocyclales 206389|Rhodocyclales C Cytochrome b/b6/petB - - - - - - - - - - - - Ni_hydr_CYTB k59_421906_1 1541065.JRFE01000017_gene27 1.31e-74 261.0 COG0515@1|root,COG0642@1|root,COG0745@1|root,COG2203@1|root,COG3899@1|root,COG4251@1|root,COG0515@2|Bacteria,COG0745@2|Bacteria,COG2203@2|Bacteria,COG2205@2|Bacteria,COG3899@2|Bacteria,COG4251@2|Bacteria,1GD97@1117|Cyanobacteria,3VI2Q@52604|Pleurocapsales 1117|Cyanobacteria KLT Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - AAA_16,GAF,GAF_2,HATPase_c,HisKA,HisKA_3,PAS_4,PAS_9,Pkinase,Response_reg k59_706068_1 1121459.AQXE01000018_gene2098 7.17e-65 208.0 COG0583@1|root,COG0583@2|Bacteria,1MWUP@1224|Proteobacteria,42P24@68525|delta/epsilon subdivisions,2WJR2@28221|Deltaproteobacteria,2M8VU@213115|Desulfovibrionales 28221|Deltaproteobacteria K TIGRFAM Transcriptional regulator, ArgP iciA - - ko:K05596 - - - - ko00000,ko03000,ko03036 - - - HTH_1,LysR_substrate k59_876508_1 1122137.AQXF01000002_gene415 3.39e-25 98.6 COG1815@1|root,COG1815@2|Bacteria,1N1G1@1224|Proteobacteria,2UCJ4@28211|Alphaproteobacteria 28211|Alphaproteobacteria N Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body flgB - - ko:K02387 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - Flg_bb_rod k59_876508_2 1122137.AQXF01000002_gene414 4.14e-72 218.0 COG1558@1|root,COG1558@2|Bacteria,1RHI3@1224|Proteobacteria,2U94I@28211|Alphaproteobacteria 28211|Alphaproteobacteria N Belongs to the flagella basal body rod proteins family flgC GO:0005575,GO:0005623,GO:0009288,GO:0009425,GO:0042995,GO:0043226,GO:0043228,GO:0044422,GO:0044461,GO:0044463,GO:0044464 - ko:K02388 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - Flg_bb_rod,Flg_bbr_C k59_1554581_1 1223543.GP2_013_00280 2.74e-15 80.9 COG1253@1|root,COG1253@2|Bacteria,2GIWR@201174|Actinobacteria,4GAY3@85026|Gordoniaceae 201174|Actinobacteria S Transporter associated domain corC GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - - - - - - - - - - CBS,CorC_HlyC,DUF21 k59_1497976_1 1131553.JIBI01000051_gene976 8.6e-81 246.0 COG0084@1|root,COG0084@2|Bacteria,1MUC0@1224|Proteobacteria,2VHCT@28216|Betaproteobacteria,372C1@32003|Nitrosomonadales 28216|Betaproteobacteria L TatD related DNase ycfH - - ko:K03424 - - - - ko00000,ko01000 - - - TatD_DNase k59_759770_1 1122137.AQXF01000001_gene3408 1.45e-120 349.0 COG1192@1|root,COG1192@2|Bacteria,1MWH3@1224|Proteobacteria,2U100@28211|Alphaproteobacteria 28211|Alphaproteobacteria D Involved in chromosome partitioning - - - ko:K03496 - - - - ko00000,ko03036,ko04812 - - - AAA_31,CbiA k59_759770_3 1265313.HRUBRA_02160 7.79e-14 70.5 COG1077@1|root,COG1077@2|Bacteria,1MUMW@1224|Proteobacteria,1RN82@1236|Gammaproteobacteria,1J52U@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria D COG1077 Actin-like ATPase involved in cell morphogenesis mreB GO:0000003,GO:0000910,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005856,GO:0005886,GO:0007049,GO:0008150,GO:0008360,GO:0009987,GO:0016020,GO:0019954,GO:0022402,GO:0022414,GO:0022603,GO:0022604,GO:0031224,GO:0031226,GO:0032505,GO:0042802,GO:0043093,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0048519,GO:0048523,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0051301,GO:0051302,GO:0051782,GO:0051983,GO:0065007,GO:0065008,GO:0071944 - ko:K03569 - - - - ko00000,ko02048,ko03036,ko04812 1.A.33.1,9.B.157.1 - - MreB_Mbl k59_647108_1 1116472.MGMO_9c00410 1.03e-38 131.0 COG3123@1|root,COG3123@2|Bacteria,1MZ8N@1224|Proteobacteria,1S9G3@1236|Gammaproteobacteria,1XFBE@135618|Methylococcales 135618|Methylococcales S Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases. Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates. Also catalyzes the reverse reactions ppnP - 2.4.2.1,2.4.2.2 ko:K09913 ko00230,ko00240,map00230,map00240 - R01561,R01570,R01863,R01876,R02147,R02296,R02297 RC00063,RC00122 ko00000,ko00001,ko01000 - - - DUF1255 k59_647108_2 261292.Nit79A3_1885 3.84e-39 141.0 COG0240@1|root,COG0240@2|Bacteria,1RED0@1224|Proteobacteria,2W2AD@28216|Betaproteobacteria 28216|Betaproteobacteria I PFAM NAD-dependent glycerol-3-phosphate dehydrogenase - - 1.1.1.94 ko:K00057 ko00564,ko01110,map00564,map01110 - R00842,R00844 RC00029 ko00000,ko00001,ko01000 - - - NAD_Gly3P_dh_C,NAD_Gly3P_dh_N k59_85775_1 1502850.FG91_00059 2.49e-23 109.0 COG1506@1|root,COG1506@2|Bacteria,1MUJ3@1224|Proteobacteria,2U08D@28211|Alphaproteobacteria,2KD2V@204457|Sphingomonadales 204457|Sphingomonadales E Prolyl oligopeptidase - - - - - - - - - - - - Peptidase_S9 k59_985282_1 640081.Dsui_3073 1.61e-67 214.0 COG0061@1|root,COG0061@2|Bacteria,1MUBC@1224|Proteobacteria,2VIV0@28216|Betaproteobacteria,2KV3J@206389|Rhodocyclales 206389|Rhodocyclales F Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP ppnK - 2.7.1.23 ko:K00858 ko00760,ko01100,map00760,map01100 - R00104 RC00002,RC00078 ko00000,ko00001,ko01000 - - - NAD_kinase k59_1437782_1 1229909.NSED_07960 5.52e-34 125.0 COG0611@1|root,arCOG00638@2157|Archaea,41SIN@651137|Thaumarchaeota 651137|Thaumarchaeota H Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 thiL - 2.7.4.16 ko:K00946 ko00730,ko01100,map00730,map01100 M00127 R00617 RC00002 ko00000,ko00001,ko00002,ko01000 - - - AIRS,AIRS_C k59_1437782_2 1229909.NSED_07955 3.34e-65 211.0 COG1109@1|root,arCOG00767@2157|Archaea,41SC1@651137|Thaumarchaeota 651137|Thaumarchaeota G phosphoglucomutase phosphomannomutase alpha beta alpha domain I - - - - - - - - - - - - PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV k59_1610379_1 489825.LYNGBM3L_73570 1.98e-16 84.3 COG0683@1|root,COG1672@1|root,COG0683@2|Bacteria,COG1672@2|Bacteria,1G4E9@1117|Cyanobacteria,1HAXK@1150|Oscillatoriales 1117|Cyanobacteria E Receptor family ligand binding region - - - ko:K01999 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - AAA_16,Peripla_BP_6,TPR_16 k59_1156718_1 1144305.PMI02_02867 8.2e-128 375.0 COG1157@1|root,COG1157@2|Bacteria,1MUH6@1224|Proteobacteria,2TRXU@28211|Alphaproteobacteria,2JZWF@204457|Sphingomonadales 204457|Sphingomonadales NU Flagellar biosynthesis type III secretory pathway ATPase fliI - 3.6.3.14 ko:K02412 ko02040,map02040 - - - ko00000,ko00001,ko01000,ko02035,ko02044 3.A.6.2,3.A.6.3 - - ATP-synt_ab k59_876546_1 697282.Mettu_3224 3.46e-78 251.0 COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,1RMBS@1236|Gammaproteobacteria,1XE8Y@135618|Methylococcales 135618|Methylococcales NU PFAM Type II secretion system protein E - - - ko:K02454 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - T2SSE,T2SSE_N k59_1046251_1 265072.Mfla_0562 4.21e-24 93.2 COG1146@1|root,COG1146@2|Bacteria,1RJJP@1224|Proteobacteria,2W4G1@28216|Betaproteobacteria 28216|Betaproteobacteria C Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions - - - ko:K05524 - - - - ko00000 - - - DUF3470,Fer4_10,Fer4_4 k59_1325353_1 929556.Solca_1033 3.16e-26 106.0 COG1044@1|root,COG1044@2|Bacteria,4NP38@976|Bacteroidetes,1IXVZ@117747|Sphingobacteriia 976|Bacteroidetes M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell - - - - - - - - - - - - - k59_647132_1 1229909.NSED_08810 1.69e-16 76.6 COG1422@1|root,arCOG02673@2157|Archaea,41SNR@651137|Thaumarchaeota 651137|Thaumarchaeota U membrane - - - - - - - - - - - - DUF106 k59_421942_1 436308.Nmar_1243 1.54e-12 66.6 COG0433@1|root,arCOG00280@2157|Archaea,41SE3@651137|Thaumarchaeota 651137|Thaumarchaeota L Domain of unknown function DUF87 - - - ko:K06915 - - - - ko00000 - - - DUF87 k59_421942_2 436308.Nmar_1242 8.68e-140 399.0 COG1630@1|root,arCOG00367@2157|Archaea,41SJX@651137|Thaumarchaeota 651137|Thaumarchaeota L NurA - - - - - - - - - - - - NurA k59_368234_2 313595.P700755_002725 6.25e-32 115.0 COG1813@1|root,COG1813@2|Bacteria,4NXM7@976|Bacteroidetes,1I6PV@117743|Flavobacteriia 976|Bacteroidetes K Helix-turn-helix XRE-family like proteins - - - - - - - - - - - - HTH_3 k59_532921_1 756067.MicvaDRAFT_5382 1.05e-48 172.0 COG0391@1|root,COG0391@2|Bacteria,1G0R0@1117|Cyanobacteria,1H815@1150|Oscillatoriales 1117|Cyanobacteria S Required for morphogenesis under gluconeogenic growth conditions - - - - - - - - - - - - UPF0052 k59_1156738_1 1122194.AUHU01000003_gene2156 1.2e-51 169.0 COG1011@1|root,COG1011@2|Bacteria,1NH15@1224|Proteobacteria,1RP27@1236|Gammaproteobacteria,466G1@72275|Alteromonadaceae 1236|Gammaproteobacteria S Haloacid dehalogenase-like hydrolase yrfG GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008252,GO:0008253,GO:0008477,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0016798,GO:0016799,GO:0030145,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0046872,GO:0046914,GO:0050483,GO:0050484 3.1.3.5 ko:K20881 ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110 - R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346 RC00017 ko00000,ko00001,ko01000 - - - HAD_2,Hydrolase k59_1156738_2 377629.TERTU_0240 1.11e-46 153.0 COG1188@1|root,COG1188@2|Bacteria,1MZR6@1224|Proteobacteria,1S8VU@1236|Gammaproteobacteria,2PNQI@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria J S4 RNA-binding domain hslR GO:0003674,GO:0003676,GO:0003677,GO:0003723,GO:0003727,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009266,GO:0009408,GO:0009451,GO:0009628,GO:0009987,GO:0016070,GO:0033554,GO:0034605,GO:0034641,GO:0043021,GO:0043023,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363 - ko:K04762 - - - - ko00000,ko03110 - - - S4 k59_929570_1 1151118.KB895783_gene3344 0.000592 48.1 COG1196@1|root,COG1196@2|Bacteria,2GK93@201174|Actinobacteria,1W7K7@1268|Micrococcaceae 201174|Actinobacteria D Required for chromosome condensation and partitioning smc - - ko:K03529 - - - - ko00000,ko03036 - - - SMC_N,SMC_hinge k59_592824_1 991905.SL003B_0832 1.72e-94 282.0 COG0411@1|root,COG0411@2|Bacteria,1MUTY@1224|Proteobacteria,2TQK1@28211|Alphaproteobacteria,4BRCY@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria E Branched-chain amino acid ATP-binding cassette transporter cysA - - ko:K01995,ko:K01998 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - ABC_tran,BCA_ABC_TP_C k59_85831_3 1038859.AXAU01000001_gene3025 1.23e-24 100.0 COG0500@1|root,COG2226@2|Bacteria,1PPKI@1224|Proteobacteria 1224|Proteobacteria Q Methyl-transferase - - - - - - - - - - - - Methyltransf_25,Methyltransf_31,Ubie_methyltran k59_421956_1 485913.Krac_6942 9.89e-09 60.1 COG4584@1|root,COG4584@2|Bacteria,2G808@200795|Chloroflexi 200795|Chloroflexi L Integrase core domain - - - - - - - - - - - - rve k59_421956_2 643648.Slip_1606 1.69e-62 204.0 COG1484@1|root,COG1484@2|Bacteria,1UYIT@1239|Firmicutes,24DFX@186801|Clostridia,42KKU@68298|Syntrophomonadaceae 186801|Clostridia L IstB-like ATP binding protein - - - - - - - - - - - - IstB_IS21 k59_929583_1 1122225.AULQ01000008_gene1281 1.11e-112 363.0 COG2373@1|root,COG2373@2|Bacteria,4NED2@976|Bacteroidetes,1HWJJ@117743|Flavobacteriia 976|Bacteroidetes P Large extracellular alpha-helical protein - - - - - - - - - - - - A2M,A2M_N,A2M_N_2,CarbopepD_reg_2 k59_1214456_1 316407.85676869 9.94e-11 60.8 COG1982@1|root,COG1982@2|Bacteria,1MWK4@1224|Proteobacteria,1RMVF@1236|Gammaproteobacteria,3XNRQ@561|Escherichia 1236|Gammaproteobacteria E Biodegradative arginine decarboxylase adiA GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006527,GO:0006807,GO:0006873,GO:0006885,GO:0008144,GO:0008150,GO:0008152,GO:0008792,GO:0009056,GO:0009063,GO:0009064,GO:0009065,GO:0009987,GO:0016054,GO:0016829,GO:0016830,GO:0016831,GO:0019725,GO:0019752,GO:0019842,GO:0030003,GO:0030004,GO:0030170,GO:0030641,GO:0036094,GO:0042592,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044464,GO:0045852,GO:0046395,GO:0048037,GO:0048878,GO:0050662,GO:0050801,GO:0051453,GO:0051454,GO:0055067,GO:0055080,GO:0055082,GO:0065007,GO:0065008,GO:0070279,GO:0071704,GO:0097159,GO:0098771,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 4.1.1.19 ko:K01584 ko00330,ko01100,map00330,map01100 M00133 R00566 RC00299 ko00000,ko00001,ko00002,ko01000 - - iEC042_1314.EC042_4483 OKR_DC_1,OKR_DC_1_C,OKR_DC_1_N k59_1214456_2 316407.85676870 2.01e-218 602.0 COG2169@1|root,COG2169@2|Bacteria,1R4BQ@1224|Proteobacteria,1RTAM@1236|Gammaproteobacteria,3XQ6C@561|Escherichia 1236|Gammaproteobacteria K Transcription activator for the expression of the melAB operon. MelR binds at two sites located upstream of the melAB transcription site melR GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1903506,GO:2000112,GO:2001141 - - - - - - - - - - HTH_18,HTH_AraC k59_706149_1 1229909.NSED_01805 1.08e-136 411.0 COG0013@1|root,arCOG01255@2157|Archaea,41SBJ@651137|Thaumarchaeota 651137|Thaumarchaeota J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain alaS - 6.1.1.7 ko:K01872 ko00970,map00970 M00359,M00360 R03038 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DHHA1,tRNA-synt_2c,tRNA_SAD k59_1384609_1 1229909.NSED_09770 6.11e-79 240.0 COG1028@1|root,arCOG01259@2157|Archaea,41SXY@651137|Thaumarchaeota 651137|Thaumarchaeota I Short-chain dehydrogenase reductase SDR - - 1.1.1.100 ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 k59_1384609_3 1229909.NSED_09760 2.59e-27 106.0 COG0483@1|root,arCOG01349@2157|Archaea,41T8P@651137|Thaumarchaeota 651137|Thaumarchaeota G Inositol monophosphatase - - 3.1.3.25,3.1.3.7 ko:K01082,ko:K01092 ko00521,ko00562,ko00920,ko01100,ko01120,ko01130,ko04070,map00521,map00562,map00920,map01100,map01120,map01130,map04070 M00131 R00188,R00508,R01185,R01186,R01187 RC00078 ko00000,ko00001,ko00002,ko01000,ko03016 - - - Inositol_P k59_368272_1 1229909.NSED_09500 2.49e-105 323.0 COG0668@1|root,arCOG01568@2157|Archaea,41SYX@651137|Thaumarchaeota 651137|Thaumarchaeota M Mechanosensitive ion channel - - - ko:K05802 - - - - ko00000,ko02000 1.A.23.1.1 - - MS_channel k59_706150_1 247633.GP2143_09295 1.31e-73 236.0 COG0154@1|root,COG0154@2|Bacteria,1MW3Z@1224|Proteobacteria,1RP33@1236|Gammaproteobacteria,1J6AR@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J COG0154 Asp-tRNAAsn Glu-tRNAGln amidotransferase A subunit and related amidases - - 6.3.5.6,6.3.5.7 ko:K02433 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - Amidase k59_1268557_1 1415778.JQMM01000001_gene2138 2.87e-16 75.9 COG2105@1|root,COG2105@2|Bacteria,1N3EK@1224|Proteobacteria,1SA6J@1236|Gammaproteobacteria,1J6PH@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Gamma-glutamyl cyclotransferase, AIG2-like - - - - - - - - - - - - GGACT k59_876596_1 1249627.D779_0836 2.25e-52 172.0 COG4619@1|root,COG4619@2|Bacteria,1QTWV@1224|Proteobacteria,1S627@1236|Gammaproteobacteria,1WXSI@135613|Chromatiales 135613|Chromatiales S ABC transporter - - - - - - - - - - - - ABC_tran k59_28779_1 1122137.AQXF01000001_gene2751 1.73e-168 483.0 COG0007@1|root,COG0007@2|Bacteria,1MUI0@1224|Proteobacteria,2TRJC@28211|Alphaproteobacteria 28211|Alphaproteobacteria H Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme cysG - 1.3.1.76,2.1.1.107,4.99.1.4 ko:K02302,ko:K02303 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R02864,R03194,R03947 RC00003,RC00871,RC01012,RC01034 ko00000,ko00001,ko00002,ko01000 - - - CysG_dimeriser,NAD_binding_7,Sirohm_synth_M,TP_methylase k59_195922_1 1282876.BAOK01000001_gene2958 3.76e-08 58.5 COG0625@1|root,COG0625@2|Bacteria,1RAP2@1224|Proteobacteria 1224|Proteobacteria O Glutathione S-transferase - - 2.5.1.18 ko:K00799 ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418 - R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905 RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944 ko00000,ko00001,ko01000,ko02000 1.A.12.2.2,1.A.12.3.2 - - GST_C,GST_C_2,GST_N_3 k59_929591_1 1085623.GNIT_3487 1.49e-18 89.4 COG0845@1|root,COG5569@1|root,COG0845@2|Bacteria,COG5569@2|Bacteria,1MVAS@1224|Proteobacteria,1RPBZ@1236|Gammaproteobacteria,464X2@72275|Alteromonadaceae 1236|Gammaproteobacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family cusB - - ko:K07798 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.6.1.4,8.A.1 - - CusF_Ec,HlyD_D23,HlyD_D4 k59_707748_1 745411.B3C1_07494 2.8e-78 239.0 COG3619@1|root,COG3619@2|Bacteria,1RB5Q@1224|Proteobacteria,1RRG5@1236|Gammaproteobacteria,1J5U6@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Protein of unknown function (DUF1275) - - - - - - - - - - - - DUF1275 k59_1666384_1 983920.Y88_2995 1.14e-88 278.0 COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,2TQMR@28211|Alphaproteobacteria,2K0VT@204457|Sphingomonadales 204457|Sphingomonadales V ABC-type multidrug transport system, ATPase and permease - - - ko:K06147 - - - - ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran k59_1100703_2 391603.FBALC1_04257 6.34e-60 188.0 2DSUM@1|root,33HGR@2|Bacteria,4PMCB@976|Bacteroidetes,1IMTF@117743|Flavobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_478725_1 316407.85675842 3.98e-178 496.0 COG3384@1|root,COG3384@2|Bacteria,1MXJZ@1224|Proteobacteria,1RR5P@1236|Gammaproteobacteria,3XNY6@561|Escherichia 1236|Gammaproteobacteria S In vitro, opens the cyclic ring of dihydroxy- phenylalanine (DOPA) between carbons 4 and 5, thus producing an unstable seco-DOPA that rearranges nonenzymatically to betalamic acid. The physiological substrate is ygiD GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0016491,GO:0046566,GO:0051213,GO:0055114 - ko:K15777 ko00965,map00965 - R08836 RC00387 ko00000,ko00001,ko01000 - - - LigB k59_87501_1 935848.JAEN01000008_gene555 6.42e-09 58.2 29CEM@1|root,2ZZD2@2|Bacteria,1REFA@1224|Proteobacteria,2U7YJ@28211|Alphaproteobacteria,2PWWK@265|Paracoccus 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_1047584_1 999141.GME_18453 3.24e-59 187.0 COG0131@1|root,COG0131@2|Bacteria,1MWBS@1224|Proteobacteria,1RPA9@1236|Gammaproteobacteria,1XIRE@135619|Oceanospirillales 135619|Oceanospirillales E Imidazoleglycerol-phosphate dehydratase hisB - 4.2.1.19 ko:K01693 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R03457 RC00932 ko00000,ko00001,ko00002,ko01000 - - - IGPD k59_1047584_2 272560.BPSL2903 9.23e-10 57.0 COG1490@1|root,COG1490@2|Bacteria,1RGTV@1224|Proteobacteria,2VR31@28216|Betaproteobacteria,1K3IP@119060|Burkholderiaceae 28216|Betaproteobacteria J rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality dtd - - ko:K07560 - - - - ko00000,ko01000,ko03016 - - - Tyr_Deacylase k59_1158315_1 526227.Mesil_1694 9.69e-69 222.0 COG3328@1|root,COG3328@2|Bacteria,1WI20@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus L COGs COG3328 Transposase and inactivated derivatives - - - - - - - - - - - - Transposase_mut k59_1269708_1 1229780.BN381_90078 1.13e-114 350.0 COG1154@1|root,COG1154@2|Bacteria,2GMFA@201174|Actinobacteria,3UW82@52018|unclassified Actinobacteria (class) 201174|Actinobacteria H Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) dxs - 2.2.1.7 ko:K01662 ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130 M00096 R05636 RC00032 ko00000,ko00001,ko00002,ko01000 - - - DXP_synthase_N,Transket_pyr,Transketolase_C k59_1777097_1 314345.SPV1_07074 1.92e-73 238.0 COG0204@1|root,COG3176@1|root,COG0204@2|Bacteria,COG3176@2|Bacteria,1MWIM@1224|Proteobacteria 1224|Proteobacteria L Hemolysin - - - - - - - - - - - - Acetyltransf_5,Acyltransferase k59_87506_1 392500.Swoo_3044 1.69e-90 280.0 COG1396@1|root,COG1396@2|Bacteria,1R3Z8@1224|Proteobacteria,1RRMV@1236|Gammaproteobacteria,2QAI5@267890|Shewanellaceae 1236|Gammaproteobacteria K Transcriptional regulator, XRE family - - - - - - - - - - - - DUF3612,HTH_19,HTH_3,Peptidase_M78 k59_648416_1 1463854.JOHT01000004_gene1037 4.09e-46 165.0 COG1022@1|root,COG1022@2|Bacteria,2GIXQ@201174|Actinobacteria 201174|Actinobacteria I AMP-dependent synthetase and ligase - - 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding k59_478732_1 1121918.ARWE01000001_gene3657 1.24e-53 175.0 COG0745@1|root,COG0745@2|Bacteria,1MVCB@1224|Proteobacteria,42RGE@68525|delta/epsilon subdivisions,2WNF7@28221|Deltaproteobacteria 28221|Deltaproteobacteria K PFAM response regulator receiver - - - - - - - - - - - - Response_reg,Trans_reg_C k59_1499645_1 316407.85676388 2.47e-76 243.0 COG2982@1|root,COG2982@2|Bacteria,1MU7Y@1224|Proteobacteria,1RN96@1236|Gammaproteobacteria,3XMHH@561|Escherichia 1236|Gammaproteobacteria M AsmA family yicH GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - - - - - - - - - - AsmA k59_1499645_2 199310.c4479 7.46e-20 87.4 COG2233@1|root,COG2233@2|Bacteria,1MUN9@1224|Proteobacteria,1RMGW@1236|Gammaproteobacteria,3XNJJ@561|Escherichia 1236|Gammaproteobacteria F Specific, proton motive force-dependent high-affinity transporter for xanthine xanP GO:0003674,GO:0005215,GO:0005345,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006863,GO:0008150,GO:0015205,GO:0015851,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0042906,GO:0042907,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0072530,GO:1904823 - ko:K03458,ko:K16345,ko:K16346 - - - - ko00000,ko02000 2.A.40,2.A.40.4.2,2.A.40.4.3 - iG2583_1286.G2583_3536,iSDY_1059.SDY_4086 Xan_ur_permease k59_313093_1 983917.RGE_28020 1.41e-74 236.0 COG1686@1|root,COG1686@2|Bacteria,1MWZA@1224|Proteobacteria,2VH1S@28216|Betaproteobacteria,1KJDZ@119065|unclassified Burkholderiales 28216|Betaproteobacteria M Belongs to the peptidase S11 family pbpG - - ko:K07262 - - - - ko00000,ko01000,ko01002,ko01011 - - - Peptidase_S11 k59_255182_1 702113.PP1Y_AT16938 4.94e-80 238.0 COG0048@1|root,COG0048@2|Bacteria,1RCWY@1224|Proteobacteria,2U70K@28211|Alphaproteobacteria,2K3W8@204457|Sphingomonadales 204457|Sphingomonadales J Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit rpsL - - ko:K02950 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosom_S12_S23 k59_1556444_1 555793.WSK_3395 2.67e-54 184.0 COG0534@1|root,COG0534@2|Bacteria,1MUAM@1224|Proteobacteria,2TSDU@28211|Alphaproteobacteria 28211|Alphaproteobacteria V Mate efflux family protein norM - - ko:K03327 - - - - ko00000,ko02000 2.A.66.1 - - MatE k59_707775_1 448385.sce4702 8.46e-149 443.0 COG0243@1|root,COG0243@2|Bacteria,1NS3T@1224|Proteobacteria,42M9Q@68525|delta/epsilon subdivisions,2WKKT@28221|Deltaproteobacteria,2Z2XB@29|Myxococcales 28221|Deltaproteobacteria C Molybdopterin oxidoreductase Fe4S4 domain - - - ko:K02567 ko00910,ko01120,map00910,map01120 M00529,M00530 R00798,R01106 RC02812 ko00000,ko00001,ko00002,ko01000 - - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding,TAT_signal k59_478741_1 1177154.Y5S_03480 4.85e-95 292.0 COG1228@1|root,COG1228@2|Bacteria,1MVAF@1224|Proteobacteria,1RQRP@1236|Gammaproteobacteria,1XMY1@135619|Oceanospirillales 135619|Oceanospirillales Q COG1228 Imidazolonepropionase and related amidohydrolases - - - - - - - - - - - - Amidohydro_1 k59_1216143_1 555793.WSK_0731 5.77e-111 323.0 COG2740@1|root,COG2740@2|Bacteria,1RHPR@1224|Proteobacteria,2U9RY@28211|Alphaproteobacteria,2K2B7@204457|Sphingomonadales 204457|Sphingomonadales K Nucleic-acid-binding protein - - - ko:K07742 - - - - ko00000 - - - DUF448 k59_1439110_1 1046724.KB889952_gene1997 7.65e-86 259.0 COG0560@1|root,COG0560@2|Bacteria,1MZPG@1224|Proteobacteria,1RRRU@1236|Gammaproteobacteria,465E1@72275|Alteromonadaceae 1236|Gammaproteobacteria E phosphoserine phosphatase thrH - 2.7.1.39,3.1.3.3 ko:K02203 ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00680,map01100,map01110,map01120,map01130,map01230 M00018 R00582,R01771 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - HAD,Hydrolase k59_1439110_2 1232410.KI421426_gene1411 6.42e-152 441.0 COG0045@1|root,COG0045@2|Bacteria,1MVCE@1224|Proteobacteria,42M5K@68525|delta/epsilon subdivisions,2WJTS@28221|Deltaproteobacteria,43T89@69541|Desulfuromonadales 28221|Deltaproteobacteria F Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit sucC - 6.2.1.5 ko:K01903 ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374,M00620 R00405,R02404 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_2261 ATP-grasp_2,Ligase_CoA k59_1439110_3 558169.AGAV01000012_gene1798 1.41e-77 241.0 COG0074@1|root,COG0074@2|Bacteria,1TPIT@1239|Firmicutes,4HA2J@91061|Bacilli 91061|Bacilli C Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit sucD - 6.2.1.5 ko:K01902 ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374,M00620 R00405,R02404 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000 - - iYO844.BSU16100 CoA_binding,Ligase_CoA k59_930807_1 436308.Nmar_1492 5.4e-30 122.0 arCOG03272@1|root,arCOG03272@2157|Archaea 436308.Nmar_1492|- - - - - - - - - - - - - - - - k59_197551_1 1216976.AX27061_5949 3.04e-87 281.0 COG2225@1|root,COG2225@2|Bacteria,1MVEV@1224|Proteobacteria,2VJMS@28216|Betaproteobacteria,3T1PS@506|Alcaligenaceae 28216|Betaproteobacteria C Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA glcB - 2.3.3.9 ko:K01638 ko00620,ko00630,ko01100,ko01110,ko01120,ko01200,map00620,map00630,map01100,map01110,map01120,map01200 M00012 R00472 RC00004,RC00308,RC02747 ko00000,ko00001,ko00002,ko01000 - - - Malate_synthase k59_817917_1 504487.JCM19302_655 2.33e-69 218.0 COG3712@1|root,COG3712@2|Bacteria,4NH8I@976|Bacteroidetes,1HXP7@117743|Flavobacteriia 976|Bacteroidetes PT Fe2 -dicitrate sensor, membrane component - - - - - - - - - - - - DUF4974,FecR k59_1269737_1 1122137.AQXF01000007_gene3583 6.07e-107 322.0 COG0591@1|root,COG0591@2|Bacteria,1MUBI@1224|Proteobacteria,2VF3C@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family - - - ko:K11928 - - - - ko00000,ko02000 2.A.21.2 - - SSF k59_484574_2 1229909.NSED_08265 2e-47 155.0 arCOG08699@1|root,arCOG08699@2157|Archaea,41S8N@651137|Thaumarchaeota 651137|Thaumarchaeota C PFAM Ammonia monooxygenase methane monooxygenase, subunit C - - - ko:K10946 ko00680,ko00910,ko01100,ko01120,ko01200,map00680,map00910,map01100,map01120,map01200 M00174,M00528,M00804 R00148,R09518 RC00173,RC02797 ko00000,ko00001,ko00002 - - - AmoC k59_147826_1 69395.JQLZ01000003_gene451 7.27e-32 128.0 COG0457@1|root,COG0457@2|Bacteria,1MVMG@1224|Proteobacteria,2TSGE@28211|Alphaproteobacteria,2KFVS@204458|Caulobacterales 204458|Caulobacterales S Sulfotransferase - - - - - - - - - - - - Sulfotransfer_3,TPR_14,TPR_16,TPR_19,TPR_8 k59_484580_2 402881.Plav_0485 7.62e-53 178.0 COG0625@1|root,COG0625@2|Bacteria,1R3VG@1224|Proteobacteria,2U50H@28211|Alphaproteobacteria 28211|Alphaproteobacteria O COG0625 Glutathione S-transferase - - - - - - - - - - - - GST_C_2,GST_N_3 k59_654749_1 926550.CLDAP_28400 2.05e-69 233.0 COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,2G5W2@200795|Chloroflexi 200795|Chloroflexi G Belongs to the PEP-utilizing enzyme family ppdK - 2.7.9.1 ko:K01006 ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200 M00169,M00171,M00172,M00173 R00206 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - PEP-utilizers,PEP-utilizers_C,PPDK_N k59_825796_1 158500.BV97_02295 1.07e-160 463.0 COG0138@1|root,COG0138@2|Bacteria,1MUDQ@1224|Proteobacteria,2TRMY@28211|Alphaproteobacteria,2K0R5@204457|Sphingomonadales 204457|Sphingomonadales F Bifunctional purine biosynthesis protein PurH purH - 2.1.2.3,3.5.4.10 ko:K00602 ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523 M00048 R01127,R04560 RC00026,RC00263,RC00456 ko00000,ko00001,ko00002,ko01000,ko04147 - - - AICARFT_IMPCHas,MGS k59_715894_1 1121904.ARBP01000003_gene6606 5.7e-10 59.3 2DFSX@1|root,2ZT12@2|Bacteria,4P99D@976|Bacteroidetes 976|Bacteroidetes - - - - - - - - - - - - - - - k59_93920_1 382464.ABSI01000012_gene2221 2.43e-91 295.0 COG0458@1|root,COG0458@2|Bacteria,46SBT@74201|Verrucomicrobia,2IU2N@203494|Verrucomicrobiae 203494|Verrucomicrobiae EF Carbamoyl-phosphate synthetase large chain, oligomerisation domain - - 6.3.5.5 ko:K01955 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - - CPSase_L_D2,CPSase_L_D3,MGS k59_1106782_1 1122226.AUHX01000004_gene1804 7.71e-92 280.0 COG1134@1|root,COG1134@2|Bacteria,4NEDM@976|Bacteroidetes,1HXJV@117743|Flavobacteriia 976|Bacteroidetes GM ABC-type polysaccharide polyol phosphate transport system ATPase component rfbB - - ko:K01990,ko:K09691 ko02010,map02010 M00250,M00254 - - ko00000,ko00001,ko00002,ko02000 3.A.1,3.A.1.103 - - ABC_tran,Wzt_C k59_205621_1 318167.Sfri_3225 2.13e-61 208.0 COG4773@1|root,COG4773@2|Bacteria,1NZCG@1224|Proteobacteria,1T1NA@1236|Gammaproteobacteria,2QC94@267890|Shewanellaceae 1236|Gammaproteobacteria P TonB dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,STN,TonB_dep_Rec k59_937119_1 991905.SL003B_2453 1.79e-76 236.0 COG1024@1|root,COG1024@2|Bacteria,1Q51H@1224|Proteobacteria,2U84X@28211|Alphaproteobacteria 28211|Alphaproteobacteria I Enoyl-CoA hydratase/isomerase - - 3.7.1.18 ko:K20765 - - - - ko00000,ko01000 - - - ECH_1 k59_147863_1 313590.MED134_09206 1.64e-40 137.0 COG2153@1|root,COG2153@2|Bacteria,4NQPR@976|Bacteroidetes,1I23R@117743|Flavobacteriia,37F7T@326319|Dokdonia 976|Bacteroidetes S Acetyltransferase (GNAT) domain elaA - - ko:K02348 - - - - ko00000 - - - Acetyltransf_10 k59_147863_2 983544.Lacal_1004 9.3e-58 187.0 COG1360@1|root,COG2885@1|root,COG1360@2|Bacteria,COG2885@2|Bacteria,4NHRP@976|Bacteroidetes,1HXVY@117743|Flavobacteriia 976|Bacteroidetes M Belongs to the ompA family - - - - - - - - - - - - OmpA k59_1332338_1 1122137.AQXF01000003_gene1991 1.4e-80 252.0 29N6M@1|root,3094I@2|Bacteria,1RKQF@1224|Proteobacteria,2U9JV@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Protein of unknown function, DUF547 - - - - - - - - - - - - DUF547 k59_321504_1 1137799.GZ78_11825 3.64e-157 446.0 COG2159@1|root,COG2159@2|Bacteria,1MUUR@1224|Proteobacteria,1S1Y6@1236|Gammaproteobacteria 1236|Gammaproteobacteria S amidohydrolase - - - - - - - - - - - - Amidohydro_2 k59_1106807_3 926550.CLDAP_22390 7.42e-28 110.0 COG0162@1|root,COG0162@2|Bacteria,2G64J@200795|Chloroflexi 200795|Chloroflexi J Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) tyrS - 6.1.1.1 ko:K01866 ko00970,map00970 M00359,M00360 R02918 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - S4,tRNA-synt_1b k59_1782376_1 1232683.ADIMK_1382 1.3e-111 335.0 COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,1RMBQ@1236|Gammaproteobacteria,464PE@72275|Alteromonadaceae 1236|Gammaproteobacteria C Belongs to the aldehyde dehydrogenase family - - 1.2.1.3,1.2.1.71 ko:K00128,ko:K06447 ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130 M00135 R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05049,R05050,R05237,R05238,R05286,R06366,R08146 RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_264005_1 114615.BRADO0276 4.91e-39 146.0 COG0624@1|root,COG0624@2|Bacteria,1MWJS@1224|Proteobacteria,2TUHT@28211|Alphaproteobacteria,3JTSY@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria E Peptidase family M20/M25/M40 - - - ko:K13049 - - - - ko00000,ko01000,ko01002 - - - M20_dimer,Peptidase_M20,Peptidase_M28 k59_94937_1 744980.TRICHSKD4_5682 2.73e-71 226.0 COG1638@1|root,COG1638@2|Bacteria,1MWAW@1224|Proteobacteria,2TV91@28211|Alphaproteobacteria 28211|Alphaproteobacteria G COG1638 TRAP-type C4-dicarboxylate transport system, periplasmic component MA20_30160 - - - - - - - - - - - DctP k59_1333488_1 234267.Acid_0086 4.09e-78 244.0 COG0596@1|root,COG0596@2|Bacteria 2|Bacteria S hydrolase activity, acting on ester bonds - - - - - - - - - - - - Abhydrolase_6,Hydrolase_4 k59_1731422_1 379066.GAU_1376 1.33e-74 233.0 COG2070@1|root,COG2070@2|Bacteria,1ZUN8@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Nitronate monooxygenase - - 1.13.12.16 ko:K00459 ko00910,map00910 - R00025 RC02541,RC02759 ko00000,ko00001,ko01000 - - - NMO k59_94939_1 1549858.MC45_17235 2.13e-14 72.4 COG0187@1|root,COG0187@2|Bacteria,1MVKT@1224|Proteobacteria,2TRBK@28211|Alphaproteobacteria,2K0E4@204457|Sphingomonadales 204457|Sphingomonadales L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrB - 5.99.1.3 ko:K02470 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim k59_94939_2 323848.Nmul_A0002 6.7e-67 214.0 COG0592@1|root,COG0592@2|Bacteria,1MVD9@1224|Proteobacteria,2VH9B@28216|Betaproteobacteria,371UF@32003|Nitrosomonadales 28216|Betaproteobacteria L Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria dnaN - 2.7.7.7 ko:K02338 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_beta,DNA_pol3_beta_2,DNA_pol3_beta_3 k59_1333489_1 565045.NOR51B_387 1.2e-70 235.0 COG0542@1|root,COG0542@2|Bacteria,1MURH@1224|Proteobacteria,1RN55@1236|Gammaproteobacteria 1236|Gammaproteobacteria O Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE clpB GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0006950,GO:0006986,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009266,GO:0009408,GO:0009628,GO:0010033,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030554,GO:0031249,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0035966,GO:0036094,GO:0042221,GO:0042623,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564 - ko:K03695 ko04213,map04213 - - - ko00000,ko00001,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N k59_887271_2 483219.LILAB_17900 2e-53 179.0 COG1385@1|root,COG1385@2|Bacteria,1MZBG@1224|Proteobacteria,42UAY@68525|delta/epsilon subdivisions,2X5BX@28221|Deltaproteobacteria,2YV3H@29|Myxococcales 28221|Deltaproteobacteria J Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit - - - - - - - - - - - - Methyltrans_RNA k59_993683_1 1229909.NSED_08690 6.74e-91 276.0 COG2262@1|root,arCOG00353@2157|Archaea,41SD4@651137|Thaumarchaeota 651137|Thaumarchaeota S GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis hflX - - ko:K03665 - - - - ko00000,ko03009 - - - GTP-bdg_M,GTP-bdg_N,MMR_HSR1 k59_938329_1 1479235.KK366039_gene1759 3.06e-15 77.4 COG3118@1|root,COG3118@2|Bacteria,1MV0R@1224|Proteobacteria,1RMSQ@1236|Gammaproteobacteria,1XJCT@135619|Oceanospirillales 135619|Oceanospirillales O Thioredoxin domain-containing protein trx-1 - - ko:K05838 - - - - ko00000,ko03110 - - - TPR_19,TPR_20,Thioredoxin k59_94947_1 1278309.KB907099_gene2520 1.43e-93 281.0 COG0714@1|root,COG0714@2|Bacteria,1MV5I@1224|Proteobacteria,1RZDH@1236|Gammaproteobacteria,1XIX3@135619|Oceanospirillales 135619|Oceanospirillales S ATPase, AAA - - - - - - - - - - - - AAA_5 k59_1783400_1 316407.85675785 4.13e-132 383.0 COG0247@1|root,COG0247@2|Bacteria,1MWTK@1224|Proteobacteria,1RPAB@1236|Gammaproteobacteria,3XPGJ@561|Escherichia 1236|Gammaproteobacteria C glycolate dehydrogenase activity glcF GO:0003674,GO:0003824,GO:0006066,GO:0006082,GO:0008150,GO:0008152,GO:0009056,GO:0009441,GO:0009987,GO:0016054,GO:0016491,GO:0016614,GO:0017144,GO:0019154,GO:0019752,GO:0032787,GO:0034308,GO:0034310,GO:0042737,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046164,GO:0046296,GO:0046395,GO:0055114,GO:0071704,GO:0072329,GO:1901575,GO:1901615,GO:1901616 - ko:K11473 ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130 - R00475 RC00042 ko00000,ko00001 - - iECABU_c1320.ECABU_c33760,iECIAI1_1343.ECIAI1_3119,iECIAI39_1322.ECIAI39_3465,iECNA114_1301.ECNA114_3053,iECP_1309.ECP_3055 CCG,Fer4_7,Fer4_8 k59_938352_1 504487.JCM19302_2283 2.19e-93 274.0 COG1595@1|root,COG1595@2|Bacteria,4NETF@976|Bacteroidetes,1HXWP@117743|Flavobacteriia 976|Bacteroidetes K Belongs to the sigma-70 factor family. ECF subfamily sigG - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 k59_938352_2 1249975.JQLP01000005_gene1984 3.29e-27 104.0 2AQR4@1|root,31FYV@2|Bacteria,4NQYS@976|Bacteroidetes,1I3DS@117743|Flavobacteriia,2P6SS@244698|Gillisia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_1618966_2 1122137.AQXF01000001_gene2768 2.91e-50 172.0 COG3264@1|root,COG3264@2|Bacteria,1MWSA@1224|Proteobacteria,2TRKK@28211|Alphaproteobacteria 28211|Alphaproteobacteria M mechanosensitive ion channel MA20_40450 - - - - - - - - - - - MS_channel k59_1055522_1 391603.FBALC1_13547 6.44e-79 248.0 COG0526@1|root,COG0526@2|Bacteria,4NH2A@976|Bacteroidetes,1HXIW@117743|Flavobacteriia 976|Bacteroidetes O Thioredoxin - - - - - - - - - - - - AhpC-TSA,Redoxin,Thioredoxin_8 k59_264025_1 33876.JNXY01000006_gene1337 5.29e-19 89.0 COG5297@1|root,COG5297@2|Bacteria,2HDPZ@201174|Actinobacteria,4DBZI@85008|Micromonosporales 201174|Actinobacteria G Belongs to the glycosyl hydrolase 12 (cellulase H) family celA1 - 3.2.1.4 ko:K01179 ko00500,ko01100,map00500,map01100 - R06200,R11307,R11308 - ko00000,ko00001,ko01000 - GH5,GH9 - CBM_2,Glyco_hydro_12 k59_938373_1 1415778.JQMM01000001_gene2244 1.87e-05 51.2 COG1196@1|root,COG4656@1|root,COG1196@2|Bacteria,COG4656@2|Bacteria,1QTUI@1224|Proteobacteria,1RMIM@1236|Gammaproteobacteria,1J4YP@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Part of a membrane complex involved in electron transport rnfC GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0055114 - ko:K03615 - - - - ko00000 - - - Complex1_51K,Fer4_10,Fer4_7,Fer4_8,RnfC_N,SLBB k59_938373_2 1122201.AUAZ01000044_gene1306 9.03e-14 70.5 COG4658@1|root,COG4658@2|Bacteria,1MVY6@1224|Proteobacteria,1RMEU@1236|Gammaproteobacteria,464JB@72275|Alteromonadaceae 1236|Gammaproteobacteria C Part of a membrane complex involved in electron transport rnfD GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016651,GO:0044464,GO:0055114,GO:0071944 - ko:K03614 - - - - ko00000 - - - NQR2_RnfD_RnfE k59_1783417_1 1049564.TevJSym_ag01080 5.43e-49 162.0 COG2922@1|root,COG2922@2|Bacteria,1RD5F@1224|Proteobacteria,1S43X@1236|Gammaproteobacteria,1J6PQ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Protein of unknown function (DUF494) smg - - ko:K03747 - - - - ko00000 - - - DUF494 k59_378959_1 102125.Xen7305DRAFT_00030060 7.81e-68 227.0 COG0365@1|root,COG0365@2|Bacteria,1G112@1117|Cyanobacteria,3VHSF@52604|Pleurocapsales 1117|Cyanobacteria I AMP-binding enzyme - - 6.2.1.1 ko:K01895 ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200 M00357 R00235,R00236,R00316,R00926,R01354 RC00004,RC00012,RC00043,RC00070,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000,ko01004 - - - ACAS_N,AMP-binding,AMP-binding_C k59_1395668_1 1122134.KB893651_gene2050 1.06e-104 310.0 COG0037@1|root,COG0037@2|Bacteria,1MW5Q@1224|Proteobacteria,1RN2H@1236|Gammaproteobacteria,1XIBX@135619|Oceanospirillales 135619|Oceanospirillales J Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32). The sulfur atoms are provided by the cysteine cysteine desulfurase (IscS) system ttcA - - ko:K14058 - - - - ko00000,ko03016 - - - ATP_bind_3 k59_1731464_1 378806.STAUR_2936 1.7e-15 76.6 COG3642@1|root,COG3642@2|Bacteria,1R9NI@1224|Proteobacteria,43BZ9@68525|delta/epsilon subdivisions,2X7A0@28221|Deltaproteobacteria,2YYM9@29|Myxococcales 28221|Deltaproteobacteria T Domain of unknown function (DUF4032) - - - - - - - - - - - - DUF4032,Kdo k59_655911_1 1123405.AUMM01000004_gene657 2.71e-13 68.9 COG0225@1|root,COG0229@1|root,COG0225@2|Bacteria,COG0229@2|Bacteria,1TQ3E@1239|Firmicutes,4HAIV@91061|Bacilli,26NA3@186821|Sporolactobacillaceae 91061|Bacilli O Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine msrB - 1.8.4.11,1.8.4.12 ko:K07304,ko:K12267 - - - - ko00000,ko01000 - - - PMSR,SelR k59_655911_2 1201288.M900_1284 5.27e-16 76.3 COG0846@1|root,COG0846@2|Bacteria,1MUK1@1224|Proteobacteria,42SWD@68525|delta/epsilon subdivisions,2MTV3@213481|Bdellovibrionales,2WK1W@28221|Deltaproteobacteria 213481|Bdellovibrionales K NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form cobB - - ko:K12410 - - - - ko00000,ko01000 - - - SIR2 k59_887317_1 436308.Nmar_1102 1.45e-23 99.0 COG3794@1|root,arCOG06255@1|root,arCOG02926@2157|Archaea,arCOG06255@2157|Archaea 2157|Archaea C PFAM blue (type 1) copper domain protein - - - - - - - - - - - - Copper-bind k59_1447020_2 305700.B447_21100 2.63e-55 182.0 COG1305@1|root,COG1305@2|Bacteria,1MVMI@1224|Proteobacteria,2VH3S@28216|Betaproteobacteria,2KUAT@206389|Rhodocyclales 206389|Rhodocyclales E Bacterial transglutaminase-like N-terminal region - - - - - - - - - - - - Bact_transglu_N,Transglut_core k59_1107979_1 45351.EDO26892 8.86e-73 228.0 COG0304@1|root,KOG1394@2759|Eukaryota,3AGBW@33154|Opisthokonta,3BYGE@33208|Metazoa 33208|Metazoa G Beta-ketoacyl synthase, N-terminal domain - - - - - - - - - - - - ketoacyl-synt k59_149362_1 158500.BV97_04618 6.94e-86 277.0 COG1629@1|root,COG4771@2|Bacteria,1MWKN@1224|Proteobacteria,2U3VD@28211|Alphaproteobacteria,2K0FN@204457|Sphingomonadales 204457|Sphingomonadales P Protein involved in receptor activity and transport - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_322581_1 1121448.DGI_0896 2.35e-11 65.5 COG0068@1|root,COG0068@2|Bacteria,1MVP8@1224|Proteobacteria,42M3G@68525|delta/epsilon subdivisions,2WJ51@28221|Deltaproteobacteria,2M8IT@213115|Desulfovibrionales 28221|Deltaproteobacteria O Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide hypF - - ko:K04656 - - - - ko00000 - - iAF987.Gmet_0119 Acylphosphatase,Sua5_yciO_yrdC,zf-HYPF k59_322581_2 1049564.TevJSym_bc00300 2.52e-97 293.0 COG0409@1|root,COG0409@2|Bacteria,1MU1F@1224|Proteobacteria,1RRTQ@1236|Gammaproteobacteria,1J9VF@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O Hydrogenase formation hypA family hypD GO:0003674,GO:0005488,GO:0005506,GO:0006464,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0019538,GO:0036211,GO:0042165,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0046872,GO:0046914,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0051604,GO:0070025,GO:0071704,GO:1901564 - ko:K04654 - - - - ko00000 - - - HypD k59_264062_1 555793.WSK_2712 6.46e-103 328.0 COG0439@1|root,COG1984@1|root,COG2049@1|root,COG4770@1|root,COG0439@2|Bacteria,COG1984@2|Bacteria,COG2049@2|Bacteria,COG4770@2|Bacteria,1MU4H@1224|Proteobacteria,2TRU5@28211|Alphaproteobacteria,2K20A@204457|Sphingomonadales 204457|Sphingomonadales EI Allophanate hydrolase subunit 2 - - 6.3.4.6 ko:K01941 ko00220,ko00791,ko01100,map00220,map00791,map01100 - R00774 RC00378 ko00000,ko00001,ko01000 - - - Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2,CT_A_B,CT_C_D k59_1276594_1 1229909.NSED_04250 1.23e-69 228.0 COG0168@1|root,COG0517@1|root,arCOG00606@2157|Archaea,arCOG04145@2157|Archaea,41SZ8@651137|Thaumarchaeota 651137|Thaumarchaeota P CBS domain - - - ko:K03498 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - - CBS,TrkH k59_1619008_1 1223410.KN050846_gene2315 1.42e-86 271.0 COG3104@1|root,COG3104@2|Bacteria,4NE8R@976|Bacteroidetes,1HWTF@117743|Flavobacteriia 976|Bacteroidetes E amino acid peptide transporter - - - ko:K03305 - - - - ko00000 2.A.17 - - PTR2 k59_1619008_2 1229204.AMYY01000003_gene952 1.28e-16 82.8 COG3104@1|root,COG3104@2|Bacteria,1MW6W@1224|Proteobacteria,2U15C@28211|Alphaproteobacteria 28211|Alphaproteobacteria E amino acid peptide transporter - - - ko:K03305 - - - - ko00000 2.A.17 - - PTR2 k59_768229_1 29760.VIT_00s0445g00020.t01 5.86e-12 65.9 COG0320@1|root,KOG2672@2759|Eukaryota,37QDC@33090|Viridiplantae,3GA64@35493|Streptophyta 35493|Streptophyta H Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives LIP1 GO:0001505,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0006082,GO:0006464,GO:0006520,GO:0006544,GO:0006546,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009056,GO:0009058,GO:0009063,GO:0009069,GO:0009071,GO:0009106,GO:0009107,GO:0009108,GO:0009249,GO:0009987,GO:0010467,GO:0016053,GO:0016054,GO:0016740,GO:0016782,GO:0016783,GO:0016992,GO:0017144,GO:0018065,GO:0018130,GO:0018193,GO:0018205,GO:0019538,GO:0019752,GO:0031974,GO:0032787,GO:0036211,GO:0042133,GO:0042135,GO:0042737,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044282,GO:0044283,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046394,GO:0046395,GO:0046483,GO:0051186,GO:0051188,GO:0051604,GO:0065007,GO:0065008,GO:0070013,GO:0070283,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1901605,GO:1901606 2.8.1.8 ko:K03644 ko00785,ko01100,map00785,map01100 - R07767,R07768 RC01978 ko00000,ko00001,ko01000 - - - LIAS_N,Radical_SAM k59_149380_2 436308.Nmar_0689 2.21e-22 89.4 arCOG08023@1|root,arCOG08023@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - zinc_ribbon_2 k59_1223496_1 546271.Selsp_1823 3.61e-07 57.0 COG0769@1|root,COG0770@1|root,COG0769@2|Bacteria,COG0770@2|Bacteria,1TPQE@1239|Firmicutes,4H2VD@909932|Negativicutes 909932|Negativicutes M Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan murE - 6.3.2.10,6.3.2.13 ko:K01928,ko:K15792 ko00300,ko00550,map00300,map00550 - R02788,R04617 RC00064,RC00090,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_1167390_1 1125863.JAFN01000001_gene2041 2.99e-69 225.0 COG0539@1|root,COG0539@2|Bacteria,1N2EJ@1224|Proteobacteria,42NXS@68525|delta/epsilon subdivisions,2WJ0A@28221|Deltaproteobacteria 28221|Deltaproteobacteria J PFAM RNA binding S1 domain protein - - - ko:K02945 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - S1 k59_39377_1 1122612.AUBA01000003_gene1545 0.000135 43.1 COG0418@1|root,COG0418@2|Bacteria,1MUYP@1224|Proteobacteria,2TT2U@28211|Alphaproteobacteria,2K057@204457|Sphingomonadales 204457|Sphingomonadales F Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate pyrC - 3.5.2.3 ko:K01465 ko00240,ko01100,map00240,map01100 M00051 R01993 RC00632 ko00000,ko00001,ko00002,ko01000 - - - Amidohydro_1 k59_39377_2 1122137.AQXF01000003_gene2330 7.74e-102 300.0 COG1280@1|root,COG1280@2|Bacteria,1N227@1224|Proteobacteria,2UCZW@28211|Alphaproteobacteria 28211|Alphaproteobacteria E lysine exporter protein (LysE YggA) - - - - - - - - - - - - LysE k59_768246_1 1298865.H978DRAFT_1629 1.71e-13 76.3 COG1404@1|root,COG1404@2|Bacteria,1QYT6@1224|Proteobacteria,1T3TK@1236|Gammaproteobacteria,46488@72275|Alteromonadaceae 1236|Gammaproteobacteria O Domain of unknown function (DUF4397) - - - - - - - - - - - - CHRD,DUF4397 k59_1404948_1 1122137.AQXF01000002_gene75 9.64e-55 177.0 COG1399@1|root,COG1399@2|Bacteria 2|Bacteria K metal-binding, possibly nucleic acid-binding protein yceD GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0040007,GO:0044424,GO:0044444,GO:0044464 - ko:K07040 - - - - ko00000 - - - DUF177 k59_1404948_2 1282876.BAOK01000001_gene1920 7.02e-34 125.0 COG5452@1|root,COG5452@2|Bacteria,1N12T@1224|Proteobacteria,2UCES@28211|Alphaproteobacteria,4BQT7@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria S Ubiquinol-cytochrome C chaperone - - - ko:K17662 - - - - ko00000,ko03029 - - - Ubiq_cyt_C_chap k59_1404948_3 1122137.AQXF01000002_gene73 2.39e-81 244.0 COG2913@1|root,COG2913@2|Bacteria,1RHYM@1224|Proteobacteria,2UBU9@28211|Alphaproteobacteria 28211|Alphaproteobacteria J Small protein A (tmRNA-binding) MA20_36760 - - - - - - - - - - - SmpA_OmlA k59_1404948_4 1122137.AQXF01000002_gene72 3.2e-140 416.0 COG3808@1|root,COG3808@2|Bacteria,1MUQ3@1224|Proteobacteria,2TR9G@28211|Alphaproteobacteria 28211|Alphaproteobacteria C Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force hppA - 3.6.1.1 ko:K15987 ko00190,map00190 - - - ko00000,ko00001,ko01000 3.A.10.1 - - H_PPase k59_948322_1 1349785.BAUG01000003_gene225 1.24e-65 202.0 COG0346@1|root,COG0346@2|Bacteria,4NNGG@976|Bacteroidetes,1I1YS@117743|Flavobacteriia 976|Bacteroidetes E Glyoxalase bleomycin resistance protein dioxygenase mce - 5.1.99.1 ko:K05606 ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200 M00373,M00375,M00376,M00741 R02765,R09979 RC00780,RC02739 ko00000,ko00001,ko00002,ko01000 - - - Glyoxalase_4 k59_948322_2 504487.JCM19302_2551 1.51e-34 121.0 COG0858@1|root,COG0858@2|Bacteria,4NSQJ@976|Bacteroidetes,1I2VE@117743|Flavobacteriia 976|Bacteroidetes J One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA rbfA - - ko:K02834 - - - - ko00000,ko03009 - - - RBFA k59_332081_1 448385.sce2408 1.47e-61 199.0 COG1077@1|root,COG1077@2|Bacteria,1MUMW@1224|Proteobacteria,42M1J@68525|delta/epsilon subdivisions,2WIQR@28221|Deltaproteobacteria,2YTUE@29|Myxococcales 28221|Deltaproteobacteria D Rod shape-determining protein mreB - - ko:K03569 - - - - ko00000,ko02048,ko03036,ko04812 1.A.33.1,9.B.157.1 - - MreB_Mbl k59_332081_3 671143.DAMO_0750 1.56e-13 73.6 COG4122@1|root,COG4122@2|Bacteria,2NQFB@2323|unclassified Bacteria 2|Bacteria S Pup-ligase protein dop GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0006464,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0010498,GO:0016787,GO:0016810,GO:0016811,GO:0017076,GO:0018193,GO:0018205,GO:0019538,GO:0019941,GO:0030163,GO:0030554,GO:0032446,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0036211,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0051603,GO:0070490,GO:0070647,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575 3.5.1.119 ko:K20814 - - - - ko00000,ko01000,ko03051 - - - Pup_ligase k59_614223_1 247633.GP2143_09045 5.93e-23 103.0 COG0845@1|root,COG0845@2|Bacteria,1PEVY@1224|Proteobacteria,1RPEQ@1236|Gammaproteobacteria,1JA4A@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - - - - - - - - - - HlyD_3 k59_1232815_1 398512.JQKC01000044_gene1271 1.62e-14 76.3 COG4974@1|root,COG4974@2|Bacteria,1TR57@1239|Firmicutes,24ACW@186801|Clostridia,3WNBT@541000|Ruminococcaceae 186801|Clostridia L Phage integrase, N-terminal SAM-like domain - - - - - - - - - - - - Phage_int_SAM_4,Phage_integrase k59_440079_1 926562.Oweho_1455 6.68e-97 315.0 COG1703@1|root,COG1884@1|root,COG2185@1|root,COG1703@2|Bacteria,COG1884@2|Bacteria,COG2185@2|Bacteria,4NFHX@976|Bacteroidetes,1HX21@117743|Flavobacteriia,2PAM0@246874|Cryomorphaceae 976|Bacteroidetes EI Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly icmF - 5.4.99.13 ko:K11942 - - - - ko00000,ko01000 - - - ArgK,B12-binding,MM_CoA_mutase k59_1518443_1 1122137.AQXF01000005_gene1141 1.17e-19 85.9 COG3346@1|root,COG3346@2|Bacteria,1MWWG@1224|Proteobacteria,2U0N5@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Surf1-like protein surf1 GO:0006996,GO:0007005,GO:0008150,GO:0008535,GO:0009987,GO:0016043,GO:0017004,GO:0022607,GO:0033108,GO:0033617,GO:0034622,GO:0043933,GO:0044085,GO:0065003,GO:0071840 - ko:K14998 - - - - ko00000,ko03029 3.D.4.8 - - SURF1 k59_1518443_2 1122137.AQXF01000005_gene1142 1.14e-31 115.0 COG5349@1|root,COG5349@2|Bacteria 2|Bacteria S Protein of unknown function (DUF983) MA20_19755 - - - - - - - - - - - DUF983 k59_1518443_3 1122137.AQXF01000005_gene1143 6.46e-182 508.0 COG1845@1|root,COG1845@2|Bacteria,1MUCK@1224|Proteobacteria,2TQWA@28211|Alphaproteobacteria 28211|Alphaproteobacteria C heme copper-type cytochrome quinol oxidase, subunit 3 ctaE GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 1.9.3.1 ko:K02276 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.4,3.D.4.6 - - COX3 k59_1518443_4 1122137.AQXF01000005_gene1144 1.2e-82 249.0 COG3175@1|root,COG3175@2|Bacteria,1RDTU@1224|Proteobacteria,2U6ZT@28211|Alphaproteobacteria 28211|Alphaproteobacteria O Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I ctaG - - ko:K02258 ko00190,ko01100,ko04714,map00190,map01100,map04714 M00154 - - ko00000,ko00001,ko00002,ko03029 3.D.4.8 - - CtaG_Cox11 k59_1628669_1 1121007.AUML01000001_gene1341 5.5e-28 116.0 COG4206@1|root,COG4206@2|Bacteria,4NI2R@976|Bacteroidetes,1HZ23@117743|Flavobacteriia,2YGXF@290174|Aquimarina 976|Bacteroidetes H Putative porin - - - - - - - - - - - - Porin_10 k59_1232823_1 339670.Bamb_4594 4.25e-88 278.0 COG0477@1|root,COG2814@2|Bacteria,1MVQQ@1224|Proteobacteria,2VKHX@28216|Betaproteobacteria,1K7SN@119060|Burkholderiaceae 28216|Betaproteobacteria EGP Sugar (and other) transporter - - - - - - - - - - - - MFS_1 k59_1232824_1 1185652.USDA257_c46300 5.05e-06 47.8 COG3311@1|root,COG3311@2|Bacteria,1NAM7@1224|Proteobacteria,2UJYF@28211|Alphaproteobacteria,4BHM7@82115|Rhizobiaceae 28211|Alphaproteobacteria K Transcriptional regulator - - - - - - - - - - - - - k59_1232824_2 1117314.PCIT_07832 2.39e-84 259.0 COG0582@1|root,COG0582@2|Bacteria,1MXUB@1224|Proteobacteria,1RPVR@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Belongs to the 'phage' integrase family - - - - - - - - - - - - Integrase_1,Phage_int_SAM_2 k59_777718_1 314278.NB231_11089 5.13e-71 227.0 COG0019@1|root,COG0019@2|Bacteria,1MUA6@1224|Proteobacteria,1RMI2@1236|Gammaproteobacteria,1WVUW@135613|Chromatiales 135613|Chromatiales E Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine lysA - 4.1.1.20 ko:K01586 ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R00451 RC00299 ko00000,ko00001,ko00002,ko01000 - - - Orn_Arg_deC_N,Orn_DAP_Arg_deC k59_1741093_1 1122223.KB890687_gene2395 1.88e-32 135.0 COG1404@1|root,COG1404@2|Bacteria,1WMNE@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus O Subtilase family - - - - - - - - - - - - PKD,Peptidase_S8 k59_440107_1 627192.SLG_07080 3.03e-85 279.0 COG0506@1|root,COG4230@1|root,COG0506@2|Bacteria,COG4230@2|Bacteria,1MV93@1224|Proteobacteria,2TQPT@28211|Alphaproteobacteria,2K1B6@204457|Sphingomonadales 204457|Sphingomonadales CE Oxidizes proline to glutamate for use as a carbon and nitrogen source putA - 1.2.1.88,1.5.5.2 ko:K13821 ko00250,ko00330,ko01100,ko01110,ko01130,map00250,map00330,map01100,map01110,map01130 - R00245,R00707,R00708,R01253,R04444,R04445,R05051 RC00080,RC00083,RC00216,RC00242,RC00255 ko00000,ko00001,ko01000,ko03000 - - - Aldedh,Pro_dh,Pro_dh-DNA_bdg k59_1793439_1 998674.ATTE01000001_gene3239 4e-25 102.0 COG0518@1|root,COG0518@2|Bacteria,1MV9U@1224|Proteobacteria,1S2MK@1236|Gammaproteobacteria,4613G@72273|Thiotrichales 72273|Thiotrichales F Glutamine amidotransferase class-I - - 6.3.5.2 ko:K01951 ko00230,ko00983,ko01100,map00230,map00983,map01100 M00050 R01230,R01231,R08244 RC00010,RC00204 ko00000,ko00001,ko00002,ko01000,ko01002 - - - GATase k59_837163_1 240015.ACP_0460 1.77e-49 176.0 COG0038@1|root,COG0038@2|Bacteria,3Y7TT@57723|Acidobacteria,2JMYW@204432|Acidobacteriia 204432|Acidobacteriia P Voltage gated chloride channel - - - ko:K03281 - - - - ko00000 2.A.49 - - Voltage_CLC k59_1683962_1 1380391.JIAS01000003_gene1877 8.77e-68 216.0 COG1028@1|root,COG1028@2|Bacteria,1MXWI@1224|Proteobacteria,2TQQ6@28211|Alphaproteobacteria,2JRYF@204441|Rhodospirillales 204441|Rhodospirillales IQ KR domain - - - - - - - - - - - - adh_short_C2 k59_777731_1 203122.Sde_0778 1.67e-46 169.0 COG3533@1|root,COG3533@2|Bacteria,1MWEN@1224|Proteobacteria,1RSMM@1236|Gammaproteobacteria,4646J@72275|Alteromonadaceae 1236|Gammaproteobacteria S Domain of unknown function - - - ko:K09955 - - - - ko00000 - - - DUF4986,Glyco_hydro_127 k59_1793456_1 1122137.AQXF01000005_gene1132 9.86e-64 208.0 COG3917@1|root,COG3917@2|Bacteria,1MV6E@1224|Proteobacteria,2TVJ4@28211|Alphaproteobacteria 28211|Alphaproteobacteria Q 2-hydroxychromene-2-carboxylate isomerase - - - - - - - - - - - - DSBA k59_1683964_1 1089553.Tph_c08500 4.39e-25 104.0 COG0138@1|root,COG0138@2|Bacteria,1TPQ5@1239|Firmicutes,24AB8@186801|Clostridia,42EZN@68295|Thermoanaerobacterales 186801|Clostridia F Bifunctional purine biosynthesis protein PurH purH - 2.1.2.3,3.5.4.10 ko:K00602 ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523 M00048 R01127,R04560 RC00026,RC00263,RC00456 ko00000,ko00001,ko00002,ko01000,ko04147 - - iHN637.CLJU_RS04230 AICARFT_IMPCHas,MGS k59_1683964_2 546271.Selsp_1017 6.68e-51 171.0 COG0299@1|root,COG0299@2|Bacteria,1V3RJ@1239|Firmicutes,4H2JI@909932|Negativicutes 909932|Negativicutes F Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate purN - 2.1.2.2 ko:K11175 ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130 M00048 R04325,R04326 RC00026,RC00197,RC01128 ko00000,ko00001,ko00002,ko01000 - - - Formyl_trans_N k59_897605_2 502025.Hoch_6687 1.33e-38 141.0 COG0003@1|root,COG0003@2|Bacteria,1PMWP@1224|Proteobacteria,42RUR@68525|delta/epsilon subdivisions,2WNEE@28221|Deltaproteobacteria,2YUU4@29|Myxococcales 28221|Deltaproteobacteria D AAA domain agmR - - - - - - - - - - - ArsA_ATPase k59_1065316_1 1131553.JIBI01000005_gene2233 2.59e-86 272.0 COG2303@1|root,COG2303@2|Bacteria,1MV19@1224|Proteobacteria,2VI6F@28216|Betaproteobacteria,371KX@32003|Nitrosomonadales 28216|Betaproteobacteria E GMC oxidoreductase - - - - - - - - - - - - GMC_oxred_C,GMC_oxred_N k59_440134_1 1283283.ATXA01000001_gene1279 2.01e-98 296.0 COG0714@1|root,COG0714@2|Bacteria,2GMM2@201174|Actinobacteria,4ETQ9@85013|Frankiales 201174|Actinobacteria S PFAM ATPase associated with various cellular activities - - - - - - - - - - - - AAA,AAA_5 k59_897617_1 436308.Nmar_1243 1.51e-148 430.0 COG0433@1|root,arCOG00280@2157|Archaea,41SE3@651137|Thaumarchaeota 651137|Thaumarchaeota L Domain of unknown function DUF87 - - - ko:K06915 - - - - ko00000 - - - DUF87 k59_1628724_1 1197906.CAJQ02000053_gene4270 2.51e-55 187.0 COG1960@1|root,COG1960@2|Bacteria,1N05C@1224|Proteobacteria,2TT9T@28211|Alphaproteobacteria,3JTG7@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria I acyl-CoA dehydrogenase MA20_06725 - 1.3.8.7 ko:K00249 ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320 M00013,M00036,M00087 R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754 RC00052,RC00068,RC00076,RC00095,RC00148,RC00246 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_N k59_1287337_1 502025.Hoch_5996 5.27e-42 151.0 COG1075@1|root,COG1075@2|Bacteria,1QTCH@1224|Proteobacteria,437VW@68525|delta/epsilon subdivisions,2WYPR@28221|Deltaproteobacteria,2YUCF@29|Myxococcales 28221|Deltaproteobacteria S acetyltransferases and hydrolases with the alpha beta hydrolase fold - - - - - - - - - - - - - k59_1065325_1 13690.CP98_01372 1.07e-85 271.0 COG3182@1|root,COG3182@2|Bacteria,1MVET@1224|Proteobacteria,2TVHW@28211|Alphaproteobacteria,2K0UQ@204457|Sphingomonadales 204457|Sphingomonadales S PepSY-associated TM region - - - - - - - - - - - - PepSY_TM k59_1406040_1 1121921.KB898713_gene1721 4.62e-78 249.0 COG1217@1|root,COG1217@2|Bacteria,1MV5Q@1224|Proteobacteria,1RMJB@1236|Gammaproteobacteria,2PN2N@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria T Elongation factor G C-terminus typA GO:0000027,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006996,GO:0008150,GO:0009266,GO:0009408,GO:0009409,GO:0009628,GO:0009987,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0042254,GO:0042255,GO:0042273,GO:0043933,GO:0044085,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0065003,GO:0070925,GO:0071826,GO:0071840 - ko:K06207 - - - - ko00000 - - - EFG_C,GTP_EFTU,GTP_EFTU_D2 k59_274480_1 366602.Caul_2432 9.1e-91 273.0 COG0300@1|root,COG0300@2|Bacteria,1RAFB@1224|Proteobacteria,2U13J@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Belongs to the short-chain dehydrogenases reductases (SDR) family - - - - - - - - - - - - adh_short k59_274480_2 76114.ebA6236 8.83e-65 206.0 COG3063@1|root,COG3063@2|Bacteria,1RD9T@1224|Proteobacteria,2VQ2E@28216|Betaproteobacteria,2KWK0@206389|Rhodocyclales 206389|Rhodocyclales NU COG0457 FOG TPR repeat - - - - - - - - - - - - - k59_216528_1 1342301.JASD01000008_gene2681 2.93e-61 199.0 COG1638@1|root,COG1638@2|Bacteria,1MVHI@1224|Proteobacteria,2TRHD@28211|Alphaproteobacteria,3ZZCJ@60136|Sulfitobacter 28211|Alphaproteobacteria G Bacterial extracellular solute-binding protein, family 7 - - - - - - - - - - - - DctP k59_897631_1 1379270.AUXF01000006_gene153 2.99e-103 321.0 COG0046@1|root,COG0046@2|Bacteria,1ZT8W@142182|Gemmatimonadetes 142182|Gemmatimonadetes F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL purL - 6.3.5.3 ko:K01952 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04463 RC00010,RC01160 ko00000,ko00001,ko00002,ko01000 - - - AIRS,AIRS_C k59_1518488_1 1459636.NTE_00888 1.49e-19 87.4 COG0589@1|root,arCOG02053@2157|Archaea 2157|Archaea T COG0589 Universal stress protein UspA and related nucleotide-binding proteins - - - ko:K20989 - - - - ko00000,ko02000 2.A.21.6 - - Usp k59_551230_1 1049564.TevJSym_ap00790 1.09e-17 86.7 COG0037@1|root,COG0037@2|Bacteria,1MU85@1224|Proteobacteria,1RN14@1236|Gammaproteobacteria,1J5PD@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria D Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine tilS GO:0002097,GO:0002101,GO:0002136,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016879,GO:0032267,GO:0034470,GO:0034641,GO:0034660,GO:0042802,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 6.3.4.19 ko:K04075 - - R09597 RC02633,RC02634 ko00000,ko01000,ko03016 - - - ATP_bind_3,TilS,TilS_C k59_1287343_1 436308.Nmar_0088 7.12e-104 325.0 COG1201@1|root,arCOG00557@2157|Archaea,41S8P@651137|Thaumarchaeota 651137|Thaumarchaeota L DEAD/H associated - - - ko:K03724 - - - - ko00000,ko01000,ko03400 - - - DEAD,DEAD_assoc,Helicase_C k59_1004010_1 1384056.N787_06560 5.62e-96 296.0 COG0111@1|root,COG0111@2|Bacteria,1MW1U@1224|Proteobacteria,1RRQE@1236|Gammaproteobacteria,1X7AT@135614|Xanthomonadales 135614|Xanthomonadales EH D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain - - - - - - - - - - - - 2-Hacid_dh_C k59_104869_1 1415778.JQMM01000001_gene8 2.33e-13 72.4 COG1729@1|root,COG1729@2|Bacteria,1MUSV@1224|Proteobacteria,1RQWA@1236|Gammaproteobacteria,1J6G5@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria D Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division cpoB GO:0005575,GO:0005623,GO:0008150,GO:0009987,GO:0016043,GO:0022607,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043933,GO:0044085,GO:0044464,GO:0051259,GO:0051260,GO:0051301,GO:0065003,GO:0071840 - - - - - - - - - - TPR_16,TPR_6,TolA_bind_tri k59_1004011_1 199310.c1676 2.58e-112 332.0 COG0387@1|root,COG0387@2|Bacteria,1MWD8@1224|Proteobacteria,1RME3@1236|Gammaproteobacteria,3XM80@561|Escherichia 1236|Gammaproteobacteria P proton antiporter chaA GO:0003674,GO:0005215,GO:0005451,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0006814,GO:0008150,GO:0008324,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015079,GO:0015081,GO:0015291,GO:0015297,GO:0015298,GO:0015299,GO:0015318,GO:0015385,GO:0015386,GO:0015491,GO:0015672,GO:0016020,GO:0016021,GO:0022804,GO:0022821,GO:0022857,GO:0022890,GO:0030001,GO:0031224,GO:0031226,GO:0034220,GO:0035725,GO:0044425,GO:0044459,GO:0044464,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0071804,GO:0071805,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:0099516,GO:1902600 - ko:K07300 - - - - ko00000,ko02000 2.A.19 - iB21_1397.B21_01204,iEC55989_1330.EC55989_1314,iECBD_1354.ECBD_2403,iECB_1328.ECB_01194,iECD_1391.ECD_01194,iECIAI1_1343.ECIAI1_1238,iECO103_1326.ECO103_1321,iECO111_1330.ECO111_1548,iECO26_1355.ECO26_1732,iECSE_1348.ECSE_1269,iECW_1372.ECW_m1308,iETEC_1333.ETEC_1322,iEcE24377_1341.EcE24377A_1366,iEcHS_1320.EcHS_A1324,iEcolC_1368.EcolC_2407,iSSON_1240.SSON_1961,iSbBS512_1146.SbBS512_E1383,iUMNK88_1353.UMNK88_1535,iWFL_1372.ECW_m1308 Na_Ca_ex k59_440174_1 702113.PP1Y_AT11612 6.05e-06 48.5 COG1396@1|root,COG1396@2|Bacteria,1MUG2@1224|Proteobacteria,2TR3R@28211|Alphaproteobacteria,2K94Y@204457|Sphingomonadales 204457|Sphingomonadales K Helix-turn-helix XRE-family like proteins - - - - - - - - - - - - HTH_31 k59_440174_2 627192.SLG_28740 1.77e-124 377.0 COG2271@1|root,COG2271@2|Bacteria,1MWYR@1224|Proteobacteria,2U1SE@28211|Alphaproteobacteria,2K2V3@204457|Sphingomonadales 204457|Sphingomonadales G Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 k59_1343648_2 1177154.Y5S_00136 9.1e-13 68.9 COG3571@1|root,COG3571@2|Bacteria,1RD20@1224|Proteobacteria,1S3Y4@1236|Gammaproteobacteria,1XK3I@135619|Oceanospirillales 135619|Oceanospirillales S hydrolase of the alpha beta-hydrolase fold - - - ko:K07020 - - - - ko00000 - - - Abhydrolase_5,Abhydrolase_6,DLH,Hydrolase_4 k59_1741147_1 1537994.JQFW01000028_gene87 1.15e-16 79.7 COG4105@1|root,COG4105@2|Bacteria,1MVS5@1224|Proteobacteria,1RSE6@1236|Gammaproteobacteria,46691@72275|Alteromonadaceae 1236|Gammaproteobacteria M Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane bamD GO:0005575,GO:0005623,GO:0008104,GO:0008150,GO:0009279,GO:0009987,GO:0016020,GO:0016043,GO:0019867,GO:0022607,GO:0030312,GO:0030313,GO:0031224,GO:0031230,GO:0031241,GO:0031246,GO:0031975,GO:0032991,GO:0033036,GO:0034613,GO:0043163,GO:0043165,GO:0044085,GO:0044091,GO:0044425,GO:0044462,GO:0044464,GO:0045184,GO:0045229,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0061024,GO:0070727,GO:0071709,GO:0071840,GO:0071944,GO:0072657,GO:0090150,GO:0098552,GO:0098796,GO:1990063 - ko:K05807 - - - - ko00000,ko02000 1.B.33.1 - - YfiO k59_1741147_2 1283300.ATXB01000001_gene407 6.56e-12 65.5 COG0564@1|root,COG0564@2|Bacteria,1MUBN@1224|Proteobacteria,1RN7F@1236|Gammaproteobacteria,1XEJR@135618|Methylococcales 135618|Methylococcales J Responsible for synthesis of pseudouridine from uracil rluD - 5.4.99.23 ko:K06180 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2,S4 k59_1232871_1 1265505.ATUG01000001_gene4766 7.16e-73 235.0 COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,42N0C@68525|delta/epsilon subdivisions,2WIUM@28221|Deltaproteobacteria,2MI28@213118|Desulfobacterales 28221|Deltaproteobacteria C Aldehyde dehydrogenase family - - 1.2.1.3 ko:K00128 ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130 M00135 R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146 RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_1575908_1 1149133.ppKF707_5256 4.21e-09 63.5 COG2207@1|root,COG2207@2|Bacteria,1RB13@1224|Proteobacteria,1S2ZB@1236|Gammaproteobacteria,1YD8A@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria K Arabinose-binding domain of AraC transcription regulator, N-term - - - - - - - - - - - - Arabinose_bd,HTH_18 k59_1628742_1 765911.Thivi_4353 5.63e-103 316.0 COG0187@1|root,COG0187@2|Bacteria,1MVH1@1224|Proteobacteria,1RMCI@1236|Gammaproteobacteria,1WXIB@135613|Chromatiales 135613|Chromatiales L Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule parE - - ko:K02622 - - - - ko00000,ko01000,ko02048,ko03032,ko03036 - - - DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim k59_1628747_2 391625.PPSIR1_37669 1.92e-48 169.0 COG0508@1|root,COG0508@2|Bacteria,1MU7K@1224|Proteobacteria,42MYB@68525|delta/epsilon subdivisions,2WIUY@28221|Deltaproteobacteria,2YU5E@29|Myxococcales 28221|Deltaproteobacteria C acetyltransferase component of pyruvate dehydrogenase complex pdhC - 2.3.1.12 ko:K00627 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200 M00307 R00209,R02569 RC00004,RC02742,RC02857 br01601,ko00000,ko00001,ko00002,ko01000 - - - 2-oxoacid_dh,Biotin_lipoyl,E3_binding k59_159296_1 1408254.T458_10840 4.33e-09 61.2 COG0664@1|root,COG0664@2|Bacteria,1VD7I@1239|Firmicutes,4HMTP@91061|Bacilli,274XP@186822|Paenibacillaceae 91061|Bacilli K helix_turn_helix, cAMP Regulatory protein - - - ko:K10914 ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111 - - - ko00000,ko00001,ko03000 - - - HTH_Crp_2,cNMP_binding k59_1628750_2 1123360.thalar_02682 2.16e-21 89.7 COG0328@1|root,COG0328@2|Bacteria,1RCZ1@1224|Proteobacteria,2U7C4@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids rnhA - 3.1.26.4 ko:K03469 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - RNase_H k59_48939_1 1229909.NSED_08960 1.95e-57 187.0 COG0803@1|root,arCOG01005@2157|Archaea,41T29@651137|Thaumarchaeota 651137|Thaumarchaeota P Periplasmic solute binding protein - - - ko:K09815 ko02010,map02010 M00242 - - ko00000,ko00001,ko00002,ko02000 3.A.1.15.3,3.A.1.15.5 - - ZnuA k59_48939_2 1229909.NSED_08955 1.66e-112 327.0 COG1121@1|root,arCOG00201@2157|Archaea,41S7E@651137|Thaumarchaeota 651137|Thaumarchaeota E PFAM ABC transporter - - - ko:K09817 ko02010,map02010 M00242 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.15.3,3.A.1.15.5 - - ABC_tran k59_1518509_1 1380600.AUYN01000003_gene184 5.47e-65 209.0 COG2755@1|root,COG2755@2|Bacteria,4NFN6@976|Bacteroidetes,1HX8X@117743|Flavobacteriia 976|Bacteroidetes E Gscfa family - - - - - - - - - - - - GSCFA k59_948414_1 1249627.D779_4092 4.14e-91 280.0 COG1173@1|root,COG1173@2|Bacteria,1MU26@1224|Proteobacteria,1RND6@1236|Gammaproteobacteria,1WW5Y@135613|Chromatiales 135613|Chromatiales EP PFAM binding-protein-dependent transport systems inner membrane component - - - ko:K02034 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1 k59_897662_1 1123401.JHYQ01000005_gene247 1.65e-68 219.0 COG0247@1|root,COG0247@2|Bacteria,1MUMH@1224|Proteobacteria,1RNBY@1236|Gammaproteobacteria,4637B@72273|Thiotrichales 72273|Thiotrichales C Fe-S oxidoreductase - - - - - - - - - - - - CCG,Fer4_8 k59_897662_2 1123401.JHYQ01000005_gene246 5.83e-15 72.4 COG2181@1|root,COG2181@2|Bacteria,1QQCT@1224|Proteobacteria,1RRNM@1236|Gammaproteobacteria 1236|Gammaproteobacteria C nitrate reductase activity - - - - - - - - - - - - - k59_389298_2 1122137.AQXF01000005_gene1101 1.41e-63 204.0 COG2189@1|root,COG2189@2|Bacteria,1MX9M@1224|Proteobacteria,2TSW9@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Belongs to the N(4) N(6)-methyltransferase family ccrM - 2.1.1.72 ko:K13581 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko02048 - - - N6_N4_Mtase k59_1065376_1 1134474.O59_003434 9.36e-114 361.0 COG0085@1|root,COG0085@2|Bacteria,1MUC4@1224|Proteobacteria,1RMK0@1236|Gammaproteobacteria,1FH46@10|Cellvibrio 1236|Gammaproteobacteria K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoB GO:0000428,GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0030880,GO:0032774,GO:0032991,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234 2.7.7.6 ko:K03043 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7 k59_1406093_1 1122925.KB895378_gene2609 2.06e-09 62.4 COG0715@1|root,COG0715@2|Bacteria,1UWSI@1239|Firmicutes,4HTDG@91061|Bacilli,26UBI@186822|Paenibacillaceae 91061|Bacilli P NMT1-like family - - - - - - - - - - - - NMT1 k59_1575948_1 1150469.RSPPHO_01095 4.63e-69 229.0 COG1217@1|root,COG1217@2|Bacteria,1MV5Q@1224|Proteobacteria,2TR63@28211|Alphaproteobacteria,2JQ9U@204441|Rhodospirillales 204441|Rhodospirillales T GTP-binding protein TypA typA - - ko:K06207 - - - - ko00000 - - - EFG_C,GTP_EFTU,GTP_EFTU_D2 k59_1232884_1 247633.GP2143_07304 1.58e-67 215.0 COG4559@1|root,COG4559@2|Bacteria,1RD7N@1224|Proteobacteria,1RPUV@1236|Gammaproteobacteria,1J8FB@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system hmuV - 3.6.3.34 ko:K02013 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.14 - - ABC_tran k59_1118165_1 765420.OSCT_2678 1.38e-39 147.0 COG2304@1|root,COG2304@2|Bacteria,2G82P@200795|Chloroflexi,374TF@32061|Chloroflexia 32061|Chloroflexia S PFAM von Willebrand factor type A - - - ko:K07114 - - - - ko00000,ko02000 1.A.13.2.2,1.A.13.2.3 - - VWA k59_551259_2 1096930.L284_06215 4.97e-20 89.4 COG0438@1|root,COG0438@2|Bacteria,1N0DG@1224|Proteobacteria,2TU8I@28211|Alphaproteobacteria,2K1WH@204457|Sphingomonadales 204457|Sphingomonadales M Glycosyl transferase 4-like - - - - - - - - - - - - Glyco_trans_1_4,Glyco_trans_4_2,Glyco_trans_4_4,Glycos_transf_1 k59_1741192_1 309801.trd_0102 3.77e-12 67.0 COG0147@1|root,COG0147@2|Bacteria,2G5M7@200795|Chloroflexi,27XZ8@189775|Thermomicrobia 189775|Thermomicrobia H Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia trpE - 4.1.3.27 ko:K01657 ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025 M00023 R00985,R00986 RC00010,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 - - - Anth_synt_I_N,Chorismate_bind k59_1741195_1 1123255.JHYS01000015_gene1112 2.29e-49 172.0 COG3034@1|root,COG3034@2|Bacteria,1N2B6@1224|Proteobacteria,2VJXB@28216|Betaproteobacteria,4A9Z4@80864|Comamonadaceae 28216|Betaproteobacteria S ErfK YbiS YcfS YnhG - - - - - - - - - - - - YkuD k59_1176951_1 436308.Nmar_0651 2.32e-138 426.0 COG1196@1|root,arCOG00371@2157|Archaea,41SDS@651137|Thaumarchaeota 651137|Thaumarchaeota D SMC proteins Flexible Hinge Domain - - - ko:K03529 - - - - ko00000,ko03036 - - - SMC_N,SMC_hinge k59_551283_1 247634.GPB2148_1444 8.52e-89 274.0 COG3243@1|root,COG3243@2|Bacteria,1MU68@1224|Proteobacteria,1RN38@1236|Gammaproteobacteria,1J7HP@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria I Alpha/beta hydrolase family phbC - - ko:K03821 ko00650,map00650 - R04254 RC00004 ko00000,ko00001,ko01000 - - - Abhydrolase_1 k59_1118187_1 502025.Hoch_4519 8e-30 111.0 COG0852@1|root,COG0852@2|Bacteria,1MX4B@1224|Proteobacteria,42NAR@68525|delta/epsilon subdivisions,2WQB1@28221|Deltaproteobacteria,2YVJM@29|Myxococcales 28221|Deltaproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoC GO:0003674,GO:0003824,GO:0003954,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564 1.6.5.3 ko:K00332 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - iAF987.Gmet_3353 Complex1_30kDa k59_1118187_2 1244531.CIG1485E_0172 3.11e-47 156.0 COG0377@1|root,COG0377@2|Bacteria,1MUI2@1224|Proteobacteria,42MDJ@68525|delta/epsilon subdivisions,2YMUT@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoB - 1.6.5.3 ko:K00331 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q6 k59_1684035_1 987059.RBXJA2T_09899 8.35e-13 65.1 COG2938@1|root,COG2938@2|Bacteria,1N2AS@1224|Proteobacteria,2VVYR@28216|Betaproteobacteria,1KMK1@119065|unclassified Burkholderiales 28216|Betaproteobacteria S Flavinator of succinate dehydrogenase - - - ko:K09159 - - - - ko00000,ko02048 - - - Sdh5 k59_216566_2 983544.Lacal_2708 8.82e-05 48.5 COG1231@1|root,COG1231@2|Bacteria,4NGST@976|Bacteroidetes,1I09T@117743|Flavobacteriia 976|Bacteroidetes E Flavin containing amine oxidoreductase - - 1.4.3.4 ko:K00274 ko00260,ko00330,ko00340,ko00350,ko00360,ko00380,ko00950,ko00982,ko01100,ko01110,ko04726,ko04728,ko05030,ko05031,ko05034,map00260,map00330,map00340,map00350,map00360,map00380,map00950,map00982,map01100,map01110,map04726,map04728,map05030,map05031,map05034 M00135 R02173,R02382,R02529,R02532,R02613,R02908,R02919,R04025,R04300,R04674,R04890,R04893,R04894,R04907,R04908,R08346,R08347,R08348,R11354 RC00062,RC00160,RC00225,RC00676,RC00807,RC00808,RC01808,RC02226,RC02713 ko00000,ko00001,ko00002,ko01000 - - - Amino_oxidase k59_159338_1 349521.HCH_03378 5.5e-30 119.0 COG0457@1|root,COG4995@1|root,COG0457@2|Bacteria,COG4995@2|Bacteria,1MWRF@1224|Proteobacteria,1T431@1236|Gammaproteobacteria,1XMNE@135619|Oceanospirillales 135619|Oceanospirillales T CHAT domain - - - - - - - - - - - - CHAT k59_847943_2 1249627.D779_1946 7.75e-96 300.0 COG0119@1|root,COG0119@2|Bacteria,1R7YB@1224|Proteobacteria,1RQB8@1236|Gammaproteobacteria,1WX74@135613|Chromatiales 135613|Chromatiales E Belongs to the alpha-IPM synthase homocitrate synthase family - - 2.3.1.182 ko:K09011 ko00290,ko00660,ko01100,ko01210,ko01230,map00290,map00660,map01100,map01210,map01230 M00535 R07399 RC00004,RC01205 br01601,ko00000,ko00001,ko00002,ko01000 - - - HMGL-like,LeuA_dimer k59_791575_1 1121403.AUCV01000002_gene547 1.21e-37 144.0 COG0168@1|root,COG0168@2|Bacteria,1N412@1224|Proteobacteria,42MBI@68525|delta/epsilon subdivisions,2WIZ9@28221|Deltaproteobacteria,2MI8M@213118|Desulfobacterales 28221|Deltaproteobacteria P TIGRFAM potassium uptake protein, TrkH family ktrB - - ko:K03498 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - - TrkH k59_1582380_1 1122137.AQXF01000001_gene2660 1.7e-38 145.0 COG0642@1|root,COG0642@2|Bacteria,1NXDJ@1224|Proteobacteria 1224|Proteobacteria T Histidine kinase - - - - - - - - - - - - GAF,HATPase_c,HisKA,Response_reg k59_1582380_2 1122137.AQXF01000003_gene2454 6.91e-147 426.0 COG0330@1|root,COG0330@2|Bacteria,1MUM2@1224|Proteobacteria,2TRTP@28211|Alphaproteobacteria 28211|Alphaproteobacteria O HflC and HflK could encode or regulate a protease hflK - - ko:K04088 - M00742 - - ko00000,ko00002,ko01000 - - - Band_7,HflK_N k59_1582380_3 488538.SAR116_0717 9.61e-08 53.5 COG0330@1|root,COG0330@2|Bacteria,1MV7R@1224|Proteobacteria,2TRP4@28211|Alphaproteobacteria,4BPGN@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria O HflC and HflK could regulate a protease hflC - - ko:K04087 - M00742 - - ko00000,ko00002,ko01000 - - - Band_7 k59_678444_1 1254432.SCE1572_42235 4.02e-63 217.0 COG0457@1|root,COG1305@1|root,COG0457@2|Bacteria,COG1305@2|Bacteria,1R5BE@1224|Proteobacteria,4339F@68525|delta/epsilon subdivisions,2WYFR@28221|Deltaproteobacteria,2YTXM@29|Myxococcales 28221|Deltaproteobacteria E Domain of Unknown Function with PDB structure (DUF3857) - - - - - - - - - - - - DUF3857,DUF3858,TPR_16,TPR_19,TPR_8,Transglut_core k59_735086_1 987059.RBXJA2T_10941 4.03e-160 478.0 COG1032@1|root,COG1032@2|Bacteria,1MUG3@1224|Proteobacteria,2VJ9A@28216|Betaproteobacteria,1KKIR@119065|unclassified Burkholderiales 28216|Betaproteobacteria C Domain of unknown function (DUF3362) - - - - - - - - - - - - DUF3362,Radical_SAM,Radical_SAM_N k59_791582_1 158500.BV97_02130 6.79e-05 43.9 COG0766@1|root,COG0766@2|Bacteria,1MUH7@1224|Proteobacteria,2TRPH@28211|Alphaproteobacteria,2K1H1@204457|Sphingomonadales 204457|Sphingomonadales M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine murA - 2.5.1.7 ko:K00790 ko00520,ko00550,ko01100,map00520,map00550,map01100 - R00660 RC00350 ko00000,ko00001,ko01000,ko01011 - - - EPSP_synthase k59_791582_2 1144305.PMI02_05506 3.19e-19 80.1 2EMS8@1|root,33FEP@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_791582_3 555793.WSK_2282 1.54e-13 65.5 COG4321@1|root,COG4321@2|Bacteria,1PSCA@1224|Proteobacteria,2VA8Q@28211|Alphaproteobacteria,2K6W1@204457|Sphingomonadales 204457|Sphingomonadales S protein related to arylsulfate sulfotransferase involved in siderophore biosynthesis - - - - - - - - - - - - RHH_4 k59_1469509_1 1122137.AQXF01000002_gene624 4.9e-128 377.0 COG0064@1|root,COG0064@2|Bacteria,1MUKG@1224|Proteobacteria,2TRHX@28211|Alphaproteobacteria 28211|Alphaproteobacteria J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) gatB GO:0003674,GO:0003824,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564 6.3.5.6,6.3.5.7 ko:K02434 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - GatB_N,GatB_Yqey k59_847949_1 105559.Nwat_0572 4.27e-32 126.0 COG1331@1|root,COG1331@2|Bacteria,1MUUT@1224|Proteobacteria,1RSQQ@1236|Gammaproteobacteria,1WWA4@135613|Chromatiales 135613|Chromatiales O Protein of unknown function, DUF255 - - - ko:K06888 - - - - ko00000 - - - Thioredox_DsbH k59_847949_2 1118235.CAJH01000040_gene2572 5.32e-32 126.0 COG0739@1|root,COG0739@2|Bacteria,1N19D@1224|Proteobacteria,1S8IP@1236|Gammaproteobacteria,1XBXP@135614|Xanthomonadales 135614|Xanthomonadales M Peptidase family M23 - - - - - - - - - - - - Peptidase_M23 k59_1469511_1 1121441.AUCX01000005_gene1319 1.86e-44 158.0 COG0530@1|root,COG0530@2|Bacteria,1MU3R@1224|Proteobacteria,42Q58@68525|delta/epsilon subdivisions,2WUIX@28221|Deltaproteobacteria,2MGSM@213115|Desulfovibrionales 28221|Deltaproteobacteria P Sodium/calcium exchanger protein - - - ko:K07301 - - - - ko00000,ko02000 2.A.19.5 - - Na_Ca_ex k59_1073868_1 102129.Lepto7375DRAFT_7506 7.19e-28 116.0 COG3209@1|root,COG3209@2|Bacteria,1G3BX@1117|Cyanobacteria,1HER8@1150|Oscillatoriales 1117|Cyanobacteria M Insecticide toxin TcdB middle/N-terminal region - - - - - - - - - - - - SpvB,TcdB_toxin_midC,TcdB_toxin_midN k59_170037_1 330084.JNYZ01000033_gene5628 2.31e-34 133.0 COG4638@1|root,COG4638@2|Bacteria,2GMB2@201174|Actinobacteria 201174|Actinobacteria P Rieske 2Fe-2S - - - - - - - - - - - - Rieske,Ring_hydroxyl_A k59_621942_1 1097668.BYI23_C003870 1.88e-41 148.0 COG0329@1|root,COG0329@2|Bacteria,1MXM5@1224|Proteobacteria,2VIKK@28216|Betaproteobacteria,1K06U@119060|Burkholderiaceae 28216|Betaproteobacteria EM Belongs to the DapA family - - 4.3.3.7 ko:K01714 ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R10147 RC03062,RC03063 ko00000,ko00001,ko00002,ko01000 - - - DHDPS k59_1469539_1 55529.EKX41003 1.48e-18 89.0 COG0637@1|root,KOG2914@2759|Eukaryota 2759|Eukaryota L pseudouridine 5'-phosphatase activity - - - - - - - - - - - - HAD_2 k59_1469539_2 266264.Rmet_1511 2.17e-13 69.3 COG0158@1|root,COG0158@2|Bacteria,1MW0E@1224|Proteobacteria,2VIJT@28216|Betaproteobacteria,1K0KJ@119060|Burkholderiaceae 28216|Betaproteobacteria G D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 fbp2 - 3.1.3.11,3.1.3.37 ko:K01086,ko:K03841 ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko04152,ko04910,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map04152,map04910 M00003,M00165,M00167,M00344 R00762,R01845,R04780 RC00017 ko00000,ko00001,ko00002,ko01000,ko04147 - - - FBPase k59_532_1 745310.G432_01470 1.5e-35 137.0 COG5276@1|root,COG5276@2|Bacteria,1R66X@1224|Proteobacteria,2U4DF@28211|Alphaproteobacteria,2K18I@204457|Sphingomonadales 204457|Sphingomonadales S LVIVD repeat - - - - - - - - - - - - LVIVD k59_621943_1 477228.YO5_01656 5.86e-111 327.0 COG1024@1|root,COG1024@2|Bacteria,1MWZC@1224|Proteobacteria,1RR3Z@1236|Gammaproteobacteria 1236|Gammaproteobacteria I Belongs to the enoyl-CoA hydratase isomerase family - - 4.2.1.17 ko:K01692 ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212 M00032,M00087 R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093 RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 - - - ECH_1 k59_226481_1 316407.85676818 5.2e-06 49.3 COG1357@1|root,COG1357@2|Bacteria,1QGYJ@1224|Proteobacteria,1SJA2@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Pentapeptide repeats (9 copies) yjcF - - - - - - - - - - - Pentapeptide k59_226481_2 316407.85676818 3.13e-58 191.0 COG1357@1|root,COG1357@2|Bacteria,1QGYJ@1224|Proteobacteria,1SJA2@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Pentapeptide repeats (9 copies) yjcF - - - - - - - - - - - Pentapeptide k59_1356436_1 710111.FraQA3DRAFT_5645 1.63e-28 117.0 COG5001@1|root,COG5001@2|Bacteria,2GIZF@201174|Actinobacteria,4ERVM@85013|Frankiales 201174|Actinobacteria T Diguanylate cyclase - - - - - - - - - - - - EAL,GGDEF k59_538_1 1380350.JIAP01000029_gene996 4.05e-38 150.0 COG4191@1|root,COG5001@1|root,COG4191@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2TQS3@28211|Alphaproteobacteria 28211|Alphaproteobacteria T Diguanylate cyclase - - - - - - - - - - - - 4HB_MCP_1,EAL,GGDEF,MHYT,PAS_4,PAS_7 k59_1243478_1 768671.ThimaDRAFT_3445 1.2e-44 155.0 COG1363@1|root,COG1363@2|Bacteria,1MXEU@1224|Proteobacteria,1RSHP@1236|Gammaproteobacteria,1WWZP@135613|Chromatiales 135613|Chromatiales G peptidase M42 - - - - - - - - - - - - Peptidase_M42 k59_1243478_2 765912.Thimo_1802 2.1e-45 160.0 COG0189@1|root,COG0454@1|root,COG0189@2|Bacteria,COG0456@2|Bacteria,1MVN2@1224|Proteobacteria,1RS1C@1236|Gammaproteobacteria,1WWH7@135613|Chromatiales 135613|Chromatiales HJ ATP-grasp - - 6.3.2.29,6.3.2.30 ko:K03802 - - - - ko00000,ko01000 - - - Acetyltransf_1,RimK k59_1300104_1 1266908.AQPB01000061_gene1139 3.17e-51 175.0 COG0547@1|root,COG0547@2|Bacteria,1MUPV@1224|Proteobacteria,1RNXV@1236|Gammaproteobacteria,1WW7U@135613|Chromatiales 135613|Chromatiales E Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) trpD - 2.4.2.18 ko:K00766 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R01073 RC00440 ko00000,ko00001,ko00002,ko01000 - - - Glycos_trans_3N,Glycos_transf_3 k59_1412942_1 1267005.KB911256_gene2040 3.86e-206 591.0 COG0376@1|root,COG0376@2|Bacteria,1MUBF@1224|Proteobacteria,2TQJ7@28211|Alphaproteobacteria 28211|Alphaproteobacteria P Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity katG GO:0000302,GO:0003674,GO:0003824,GO:0004096,GO:0004601,GO:0005488,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009636,GO:0009987,GO:0010035,GO:0016209,GO:0016491,GO:0016684,GO:0016999,GO:0017001,GO:0017144,GO:0020037,GO:0033554,GO:0034599,GO:0034614,GO:0035690,GO:0042221,GO:0042493,GO:0042542,GO:0042737,GO:0042743,GO:0042744,GO:0044237,GO:0044248,GO:0044424,GO:0044444,GO:0044464,GO:0046677,GO:0046906,GO:0048037,GO:0050896,GO:0051186,GO:0051187,GO:0051716,GO:0055114,GO:0070301,GO:0070887,GO:0071236,GO:0072593,GO:0097159,GO:0097237,GO:0098754,GO:0098869,GO:1901363,GO:1901700,GO:1901701,GO:1990748 1.11.1.21 ko:K03782 ko00360,ko00380,ko00940,ko00983,ko01100,ko01110,map00360,map00380,map00940,map00983,map01100,map01110 - R00602,R00698,R02596,R02670,R03919,R04007,R07443,R11906 RC00034,RC00213,RC00767,RC02141 ko00000,ko00001,ko01000 - - - peroxidase k59_339643_1 870187.Thini_1592 7.73e-56 180.0 COG0745@1|root,COG0745@2|Bacteria,1N0YI@1224|Proteobacteria,1S0IN@1236|Gammaproteobacteria,463NM@72273|Thiotrichales 72273|Thiotrichales K PFAM Response regulator receiver domain - - - - - - - - - - - - Response_reg,Trans_reg_C k59_339643_2 754476.Q7A_414 4.26e-10 57.8 COG3212@1|root,COG3212@2|Bacteria,1NHDB@1224|Proteobacteria,1SH2G@1236|Gammaproteobacteria 1236|Gammaproteobacteria S peptidase - - - - - - - - - - - - PepSY k59_1243486_2 1163617.SCD_n00562 7.1e-47 161.0 COG0517@1|root,COG0794@1|root,COG0517@2|Bacteria,COG0794@2|Bacteria,1MUXD@1224|Proteobacteria,2VI24@28216|Betaproteobacteria 28216|Betaproteobacteria M Belongs to the SIS family. GutQ KpsF subfamily kdsD - 5.3.1.13 ko:K06041 ko00540,ko01100,map00540,map01100 M00063 R01530 RC00541 ko00000,ko00001,ko00002,ko01000,ko01005 - - - CBS,SIS k59_452399_1 876044.IMCC3088_2167 2.57e-74 231.0 COG0685@1|root,COG0685@2|Bacteria,1MUC9@1224|Proteobacteria,1RMXS@1236|Gammaproteobacteria,1J562@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E COG0685 5,10-methylenetetrahydrofolate reductase metF GO:0000166,GO:0003674,GO:0003824,GO:0004489,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006575,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009396,GO:0009987,GO:0016043,GO:0016053,GO:0016491,GO:0016645,GO:0016646,GO:0018130,GO:0019438,GO:0019752,GO:0022607,GO:0034641,GO:0036094,GO:0042398,GO:0042558,GO:0042559,GO:0043167,GO:0043168,GO:0043436,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046653,GO:0046654,GO:0048037,GO:0050660,GO:0050662,GO:0051186,GO:0051188,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:0071949,GO:0097159,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 1.5.1.20 ko:K00297 ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,map00670,map00720,map01100,map01120,map01200,map01523 M00377 R01224,R07168 RC00081 ko00000,ko00001,ko00002,ko01000 - - iPC815.YPO0117,iSBO_1134.SBO_3961 MTHFR k59_847991_1 1172185.KB911511_gene3035 1.31e-104 318.0 COG4638@1|root,COG4638@2|Bacteria,2GMB2@201174|Actinobacteria,4FW0J@85025|Nocardiaceae 201174|Actinobacteria P Ring hydroxylating alpha subunit (catalytic domain) - - - - - - - - - - - - Rieske,Ring_hydroxyl_A k59_1243489_1 1255043.TVNIR_0850 6.64e-15 74.3 COG0437@1|root,COG0437@2|Bacteria,1NBU3@1224|Proteobacteria,1RRYZ@1236|Gammaproteobacteria,1WVZM@135613|Chromatiales 135613|Chromatiales C PFAM 4Fe-4S ferredoxin iron-sulfur binding domain protein - - - ko:K00184 - - - - ko00000 5.A.3 - - Fer4_11,Fer4_7 k59_1243489_2 1163617.SCD_n02709 2.99e-29 110.0 2E6CU@1|root,3310G@2|Bacteria,1N0TM@1224|Proteobacteria,2VV3Z@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_1130624_1 1121948.AUAC01000002_gene1823 7.52e-129 378.0 COG0665@1|root,COG0665@2|Bacteria,1R40G@1224|Proteobacteria,2U1VU@28211|Alphaproteobacteria 28211|Alphaproteobacteria E FAD dependent oxidoreductase - - - - - - - - - - - - DAO k59_1073889_1 1229909.NSED_05135 6.06e-174 498.0 COG0504@1|root,arCOG00063@2157|Archaea,41S7G@651137|Thaumarchaeota 651137|Thaumarchaeota F Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates pyrG - 6.3.4.2 ko:K01937 ko00240,ko01100,map00240,map01100 M00052 R00571,R00573 RC00010,RC00074 ko00000,ko00001,ko00002,ko01000 - - - CTP_synth_N,GATase k59_1751985_1 1395571.TMS3_0100155 1.78e-70 224.0 COG1995@1|root,COG1995@2|Bacteria,1MX5W@1224|Proteobacteria,1RNZV@1236|Gammaproteobacteria 1236|Gammaproteobacteria H Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) pdxA GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006081,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008614,GO:0008615,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0034641,GO:0036094,GO:0042364,GO:0042802,GO:0042816,GO:0042819,GO:0042822,GO:0042823,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046184,GO:0046483,GO:0046872,GO:0046914,GO:0048037,GO:0050570,GO:0050662,GO:0051186,GO:0051188,GO:0051287,GO:0055114,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 1.1.1.262 ko:K00097 ko00750,ko01100,map00750,map01100 M00124 R05681,R05837,R07406 RC00089,RC00675,RC01475 ko00000,ko00001,ko00002,ko01000 - - iECO111_1330.ECO111_0056 PdxA k59_1243494_1 251221.35210568 2.35e-22 94.7 COG0226@1|root,COG0226@2|Bacteria,1FZZ0@1117|Cyanobacteria 1117|Cyanobacteria P TIGRFAM phosphate binding protein sphX GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K02040 ko02010,ko02020,ko05152,map02010,map02020,map05152 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - PBP_like,PBP_like_2 k59_1243494_2 582744.Msip34_1860 2.76e-17 82.0 COG0573@1|root,COG0573@2|Bacteria,1MVKP@1224|Proteobacteria,2VH4G@28216|Betaproteobacteria,2KKVV@206350|Nitrosomonadales 206350|Nitrosomonadales P probably responsible for the translocation of the substrate across the membrane - - - ko:K02037 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - BPD_transp_1 k59_791646_1 1122137.AQXF01000001_gene2497 9.23e-198 553.0 COG0794@1|root,COG0794@2|Bacteria,1MUXD@1224|Proteobacteria,2TU5X@28211|Alphaproteobacteria 28211|Alphaproteobacteria M Belongs to the SIS family. GutQ KpsF subfamily kpsF - 5.3.1.13 ko:K06041 ko00540,ko01100,map00540,map01100 M00063 R01530 RC00541 ko00000,ko00001,ko00002,ko01000,ko01005 - - - CBS,SIS k59_1751990_1 1545915.JROG01000007_gene3067 1.54e-29 110.0 COG0663@1|root,COG0663@2|Bacteria,1RD76@1224|Proteobacteria,2U5GR@28211|Alphaproteobacteria,2K4AW@204457|Sphingomonadales 204457|Sphingomonadales S COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily - - - - - - - - - - - - Hexapep k59_1751990_2 1255043.TVNIR_2798 8.05e-26 102.0 COG1136@1|root,COG1136@2|Bacteria,1MU45@1224|Proteobacteria,1RR3R@1236|Gammaproteobacteria,1WXTU@135613|Chromatiales 135613|Chromatiales V ABC transporter - - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_848005_1 187272.Mlg_2272 2.73e-30 108.0 COG1598@1|root,COG1598@2|Bacteria,1NBIX@1224|Proteobacteria,1SCV3@1236|Gammaproteobacteria,1WZ6M@135613|Chromatiales 135613|Chromatiales S HicB_like antitoxin of bacterial toxin-antitoxin system - - - - - - - - - - - - HicB_lk_antitox k59_565710_1 1485544.JQKP01000003_gene194 2.03e-38 151.0 COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,2VHAN@28216|Betaproteobacteria,44W70@713636|Nitrosomonadales 28216|Betaproteobacteria V ABC transporter transmembrane region - - - ko:K06147 - - - - ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran k59_170076_1 436308.Nmar_0657 6.25e-96 290.0 COG1262@1|root,arCOG03517@2157|Archaea,41T1B@651137|Thaumarchaeota 651137|Thaumarchaeota S DinB superfamily - - - - - - - - - - - - DinB_2,FGE-sulfatase k59_170076_2 436308.Nmar_0653 1.72e-33 124.0 COG4301@1|root,arCOG06722@2157|Archaea,41SWR@651137|Thaumarchaeota 651137|Thaumarchaeota S Histidine-specific methyltransferase, SAM-dependent - - - - - - - - - - - - Methyltransf_33 k59_574_2 1229909.NSED_00935 2.25e-54 177.0 COG1402@1|root,arCOG04536@2157|Archaea,41SNC@651137|Thaumarchaeota 651137|Thaumarchaeota H Creatinine amidohydrolase - - 3.5.2.10 ko:K01470 ko00330,map00330 - R01884 RC00615 ko00000,ko00001,ko01000 - - - Creatininase k59_1130643_2 335283.Neut_2322 2.39e-38 139.0 COG4942@1|root,COG4942@2|Bacteria,1RD24@1224|Proteobacteria,2VINR@28216|Betaproteobacteria,3727U@32003|Nitrosomonadales 28216|Betaproteobacteria DM Lysin motif - - - ko:K06194 - - - - ko00000 1.A.34.1.2 - - LysM,Peptidase_M23 k59_1300564_1 1282876.BAOK01000002_gene550 6.04e-66 214.0 COG1960@1|root,COG1960@2|Bacteria,1MXMQ@1224|Proteobacteria,2U0CV@28211|Alphaproteobacteria 28211|Alphaproteobacteria I acyl-CoA dehydrogenase - - 1.14.13.235 ko:K22027 - - - - ko00000,ko01000 - - - Acyl-CoA_dh_2,Acyl-CoA_dh_N k59_1526353_1 1286632.P278_15990 1.2e-16 79.0 COG2207@1|root,COG2207@2|Bacteria,4NIRD@976|Bacteroidetes,1I0T7@117743|Flavobacteriia 976|Bacteroidetes K dna-binding - - - - - - - - - - - - HTH_18 k59_1526353_2 765912.Thimo_0956 2.08e-20 89.4 COG1024@1|root,COG1024@2|Bacteria,1MUD7@1224|Proteobacteria,1RSI6@1236|Gammaproteobacteria,1X2EM@135613|Chromatiales 135613|Chromatiales I Belongs to the enoyl-CoA hydratase isomerase family - - - ko:K13816 ko02020,ko02024,map02020,map02024 - - - ko00000,ko00001 - - - ECH_1 k59_340078_1 1156937.MFUM_300009 4.42e-165 481.0 COG1053@1|root,COG1053@2|Bacteria,46S7D@74201|Verrucomicrobia,37FY2@326457|unclassified Verrucomicrobia 74201|Verrucomicrobia C Fumarate reductase flavoprotein C-term sdhA - 1.3.5.1,1.3.5.4 ko:K00239 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134 M00009,M00011,M00149,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,Succ_DH_flav_C k59_1752313_1 857087.Metme_1574 2.16e-38 146.0 COG1752@1|root,COG1752@2|Bacteria,1QJJS@1224|Proteobacteria,1THK7@1236|Gammaproteobacteria,1XENQ@135618|Methylococcales 135618|Methylococcales S Patatin-like phospholipase - - - - - - - - - - - - Patatin k59_735589_1 305900.GV64_09630 1.49e-102 311.0 COG0161@1|root,COG0161@2|Bacteria,1MU2N@1224|Proteobacteria,1RP0C@1236|Gammaproteobacteria,1XHQT@135619|Oceanospirillales 135619|Oceanospirillales E Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family - - - - - - - - - - - - Aminotran_3 k59_678909_1 1123236.KB899388_gene2054 9.29e-22 99.4 COG1629@1|root,COG1629@2|Bacteria,1MV8W@1224|Proteobacteria,1RQEQ@1236|Gammaproteobacteria,463XU@72275|Alteromonadaceae 1236|Gammaproteobacteria P COG1629 Outer membrane receptor proteins, mostly Fe transport - - - - - - - - - - - - Plug,TonB_dep_Rec k59_792095_1 713587.THITH_16940 2.37e-29 108.0 COG0251@1|root,COG0251@2|Bacteria,1MZ3J@1224|Proteobacteria,1S5XS@1236|Gammaproteobacteria,1WY7E@135613|Chromatiales 135613|Chromatiales J PFAM Endoribonuclease L-PSP - - 3.5.99.10 ko:K09022 - - R11098,R11099 RC03275,RC03354 ko00000,ko01000 - - - Ribonuc_L-PSP k59_792095_2 743299.Acife_2220 2.8e-11 64.7 COG1200@1|root,COG1200@2|Bacteria,1MWN2@1224|Proteobacteria,1RMMQ@1236|Gammaproteobacteria,2NCR6@225057|Acidithiobacillales 225057|Acidithiobacillales L Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) recG - 3.6.4.12 ko:K03655 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,Helicase_C,RecG_wedge k59_114042_1 93220.LV28_06080 2.49e-61 206.0 COG0248@1|root,COG0248@2|Bacteria,1MV35@1224|Proteobacteria,2VI1K@28216|Betaproteobacteria,1K0ST@119060|Burkholderiaceae 28216|Betaproteobacteria FP PFAM Ppx GppA phosphatase ppx - 3.6.1.11,3.6.1.40 ko:K01524 ko00230,map00230 - R03409 RC00002 ko00000,ko00001,ko01000 - - - Ppx-GppA k59_452842_1 1122613.ATUP01000001_gene1599 3.75e-23 98.2 COG1301@1|root,COG1301@2|Bacteria,1MU0Q@1224|Proteobacteria,2TUFB@28211|Alphaproteobacteria,43Z26@69657|Hyphomonadaceae 28211|Alphaproteobacteria C Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family - - - - - - - - - - - - SDF k59_1074261_1 1168065.DOK_18630 6.34e-85 271.0 COG2010@1|root,COG4993@1|root,COG2010@2|Bacteria,COG4993@2|Bacteria,1MUQX@1224|Proteobacteria,1RN5D@1236|Gammaproteobacteria,1J8FD@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C PQQ-like domain - - 1.1.2.8,1.1.9.1 ko:K00114,ko:K17760 ko00010,ko00625,ko01100,ko01110,ko01120,ko01130,map00010,map00625,map01100,map01110,map01120,map01130 - R05062,R05198,R05285 RC00087,RC00088,RC01039 ko00000,ko00001,ko01000 - - - Cytochrome_CBB3,PQQ,PQQ_2 k59_678918_1 1274.HX89_03725 7.64e-68 226.0 COG0480@1|root,COG0480@2|Bacteria,2GKB3@201174|Actinobacteria,1ZVJ6@145357|Dermacoccaceae 201174|Actinobacteria J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome fusA GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944 - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2 k59_792106_2 1209072.ALBT01000061_gene943 5.54e-45 159.0 COG1652@1|root,COG1652@2|Bacteria,1MUBV@1224|Proteobacteria,1RPMB@1236|Gammaproteobacteria,1FFZF@10|Cellvibrio 1236|Gammaproteobacteria S LysM domain lysM - - - - - - - - - - - LysM k59_1695773_1 1198232.CYCME_2324 5.57e-83 261.0 COG0119@1|root,COG0119@2|Bacteria,1R7YB@1224|Proteobacteria,1RQB8@1236|Gammaproteobacteria,4622G@72273|Thiotrichales 72273|Thiotrichales E LeuA allosteric (dimerisation) domain - - 2.3.1.182 ko:K09011 ko00290,ko00660,ko01100,ko01210,ko01230,map00290,map00660,map01100,map01210,map01230 M00535 R07399 RC00004,RC01205 br01601,ko00000,ko00001,ko00002,ko01000 - - - HMGL-like,LeuA_dimer k59_1469991_1 1121930.AQXG01000002_gene1952 2.26e-23 105.0 COG1042@1|root,COG1042@2|Bacteria,4NFTI@976|Bacteroidetes,1IVTU@117747|Sphingobacteriia 976|Bacteroidetes C CoA binding domain - - - ko:K09181 - - - - ko00000 - - - ATP-grasp_5,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig k59_1074267_1 702113.PP1Y_AT29441 3.78e-188 545.0 COG0642@1|root,COG0642@2|Bacteria,1QWE6@1224|Proteobacteria,2TWWP@28211|Alphaproteobacteria,2KEEF@204457|Sphingomonadales 204457|Sphingomonadales T PAS fold - - - - - - - - - - - - HATPase_c,HisKA,PAS_7 k59_1018161_1 316407.85674522 7.03e-108 318.0 COG1181@1|root,COG1181@2|Bacteria,1MUTB@1224|Proteobacteria,1RMTM@1236|Gammaproteobacteria,3XP25@561|Escherichia 1236|Gammaproteobacteria F Cell wall formation ddl GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008716,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009314,GO:0009628,GO:0009987,GO:0010165,GO:0010212,GO:0016874,GO:0016879,GO:0016881,GO:0030203,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 6.3.2.4 ko:K01921 ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502 - R01150 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - iAF1260.b0381,iB21_1397.B21_00332,iBWG_1329.BWG_0265,iE2348C_1286.E2348C_0317,iEC042_1314.EC042_0413,iEC55989_1330.EC55989_0386,iECBD_1354.ECBD_3283,iECB_1328.ECB_00328,iECDH10B_1368.ECDH10B_0338,iECDH1ME8569_1439.ECDH1ME8569_0367,iECD_1391.ECD_00328,iECH74115_1262.ECH74115_0453,iECIAI1_1343.ECIAI1_0377,iECIAI39_1322.ECIAI39_0301,iECO103_1326.ECO103_0356,iECO111_1330.ECO111_0411,iECO26_1355.ECO26_0414,iECSE_1348.ECSE_0401,iECSP_1301.ECSP_0441,iECs_1301.ECs0431,iETEC_1333.ETEC_0434,iEcDH1_1363.EcDH1_3227,iEcE24377_1341.EcE24377A_0406,iEcHS_1320.EcHS_A0447,iEcSMS35_1347.EcSMS35_0410,iEcolC_1368.EcolC_3251,iJO1366.b0381,iJR904.b0381,iSF_1195.SF0232,iSFxv_1172.SFxv_0245,iS_1188.S0254,iUMNK88_1353.UMNK88_429,iY75_1357.Y75_RS01965,iZ_1308.Z0477 Dala_Dala_lig_C,Dala_Dala_lig_N k59_396487_1 158500.BV97_04553 8.64e-104 321.0 COG1629@1|root,COG4771@2|Bacteria,1MWKN@1224|Proteobacteria 1224|Proteobacteria P COG1629 Outer membrane receptor proteins, mostly Fe transport - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_114060_1 436308.Nmar_0738 1.23e-10 58.9 COG1522@1|root,arCOG01580@2157|Archaea,41T4E@651137|Thaumarchaeota 651137|Thaumarchaeota K helix_turn_helix ASNC type - - - - - - - - - - - - AsnC_trans_reg,HTH_AsnC-type k59_1413390_1 234267.Acid_1797 7.51e-21 89.0 COG4319@1|root,COG4319@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - DUF4440,SnoaL_2,SnoaL_4 k59_1413390_2 264730.PSPPH_1325 2.31e-09 57.4 COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,1RNN0@1236|Gammaproteobacteria,1Z6FW@136849|Pseudomonas syringae group 1236|Gammaproteobacteria E Aminotransferase ybdL - 2.6.1.88 ko:K14287 - - R08618 RC00006,RC00025 ko00000,ko01000,ko01007 - - - Aminotran_1_2 k59_904853_1 1215092.PA6_020_01200 8.02e-07 50.8 2DR2Y@1|root,339YA@2|Bacteria,1NHB7@1224|Proteobacteria,1SDH6@1236|Gammaproteobacteria,1YKTT@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria M Domain of unknown function (DUF4124) - - - - - - - - - - - - DUF4124 k59_904853_2 1463926.JOCA01000004_gene5051 1.52e-36 140.0 COG1680@1|root,COG1680@2|Bacteria,2GJJB@201174|Actinobacteria 201174|Actinobacteria V COG1680 Beta-lactamase class C and other penicillin binding proteins - - - - - - - - - - - - Beta-lactamase k59_509454_1 998674.ATTE01000001_gene1417 6.51e-100 300.0 COG0075@1|root,COG0075@2|Bacteria,1QCKV@1224|Proteobacteria,1RQ1T@1236|Gammaproteobacteria 1236|Gammaproteobacteria E aminotransferase - - - - - - - - - - - - Aminotran_5 k59_848460_1 1122137.AQXF01000005_gene1147 1.26e-119 355.0 COG0843@1|root,COG0843@2|Bacteria,1MU7S@1224|Proteobacteria,2TQP1@28211|Alphaproteobacteria 28211|Alphaproteobacteria C Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B ctaD GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015672,GO:0015980,GO:0015988,GO:0015990,GO:0016020,GO:0022900,GO:0022904,GO:0034220,GO:0044237,GO:0044464,GO:0045333,GO:0051179,GO:0051234,GO:0055085,GO:0055114,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:1902600 1.9.3.1 ko:K02274 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6 - - COX1 k59_574564_1 420662.Mpe_A0260 7.63e-71 222.0 COG0057@1|root,COG0057@2|Bacteria,1MU93@1224|Proteobacteria,2VHHG@28216|Betaproteobacteria,1KKA5@119065|unclassified Burkholderiales 28216|Betaproteobacteria C Belongs to the glyceraldehyde-3-phosphate dehydrogenase family gap GO:0000166,GO:0000226,GO:0001817,GO:0001819,GO:0001906,GO:0001907,GO:0002376,GO:0002791,GO:0002793,GO:0003674,GO:0003824,GO:0004365,GO:0004857,GO:0004866,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005635,GO:0005737,GO:0005811,GO:0005829,GO:0005856,GO:0005886,GO:0005975,GO:0005996,GO:0006006,GO:0006007,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006417,GO:0006464,GO:0006725,GO:0006732,GO:0006733,GO:0006734,GO:0006735,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0006915,GO:0006950,GO:0006952,GO:0006955,GO:0006959,GO:0006996,GO:0007010,GO:0007017,GO:0008017,GO:0008092,GO:0008150,GO:0008152,GO:0008219,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009435,GO:0009605,GO:0009607,GO:0009620,GO:0009889,GO:0009890,GO:0009892,GO:0009894,GO:0009987,GO:0010033,GO:0010466,GO:0010468,GO:0010506,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0010941,GO:0010942,GO:0010951,GO:0012501,GO:0012505,GO:0015630,GO:0015631,GO:0016020,GO:0016043,GO:0016051,GO:0016052,GO:0016053,GO:0016241,GO:0016310,GO:0016491,GO:0016620,GO:0016740,GO:0016769,GO:0016903,GO:0017014,GO:0017144,GO:0017148,GO:0018119,GO:0018130,GO:0018193,GO:0018198,GO:0019222,GO:0019318,GO:0019319,GO:0019320,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019538,GO:0019637,GO:0019674,GO:0019693,GO:0019730,GO:0019752,GO:0019828,GO:0019904,GO:0030162,GO:0030234,GO:0030414,GO:0031090,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031329,GO:0031341,GO:0031343,GO:0031640,GO:0031647,GO:0031965,GO:0031967,GO:0031975,GO:0032268,GO:0032269,GO:0032787,GO:0032879,GO:0032880,GO:0032991,GO:0034097,GO:0034248,GO:0034249,GO:0034341,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0035605,GO:0035606,GO:0035821,GO:0036094,GO:0036211,GO:0042221,GO:0042802,GO:0042866,GO:0042981,GO:0043065,GO:0043067,GO:0043068,GO:0043086,GO:0043170,GO:0043207,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043412,GO:0043436,GO:0043891,GO:0043900,GO:0043902,GO:0043903,GO:0044003,GO:0044004,GO:0044068,GO:0044092,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044267,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0044364,GO:0044403,GO:0044419,GO:0044422,GO:0044424,GO:0044428,GO:0044444,GO:0044446,GO:0044464,GO:0044531,GO:0044532,GO:0044533,GO:0045087,GO:0045861,GO:0046031,GO:0046034,GO:0046364,GO:0046365,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0048037,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050662,GO:0050707,GO:0050708,GO:0050714,GO:0050715,GO:0050789,GO:0050790,GO:0050794,GO:0050821,GO:0050832,GO:0050896,GO:0051046,GO:0051047,GO:0051049,GO:0051050,GO:0051171,GO:0051172,GO:0051186,GO:0051188,GO:0051222,GO:0051223,GO:0051239,GO:0051240,GO:0051246,GO:0051248,GO:0051287,GO:0051336,GO:0051346,GO:0051402,GO:0051701,GO:0051702,GO:0051704,GO:0051707,GO:0051709,GO:0051712,GO:0051716,GO:0051817,GO:0051818,GO:0051851,GO:0051852,GO:0051873,GO:0051883,GO:0052040,GO:0052042,GO:0052248,GO:0052330,GO:0052433,GO:0052501,GO:0052547,GO:0052548,GO:0055086,GO:0055114,GO:0060255,GO:0061134,GO:0061135,GO:0061615,GO:0061620,GO:0061621,GO:0061718,GO:0061844,GO:0065007,GO:0065008,GO:0065009,GO:0070201,GO:0070887,GO:0070997,GO:0071310,GO:0071345,GO:0071346,GO:0071704,GO:0071840,GO:0071944,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0080090,GO:0090087,GO:0090407,GO:0097159,GO:0097452,GO:0097718,GO:0098542,GO:0098772,GO:0140096,GO:1901135,GO:1901137,GO:1901265,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1903530,GO:1903532,GO:1904951,GO:1990904,GO:2000112,GO:2000113 1.2.1.12 ko:K00134 ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01061 RC00149 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - Gp_dh_C,Gp_dh_N k59_574564_2 62928.azo2836 8.97e-64 214.0 COG0021@1|root,COG0021@2|Bacteria,1MUEY@1224|Proteobacteria,2VHNX@28216|Betaproteobacteria,2KV91@206389|Rhodocyclales 206389|Rhodocyclales H Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate tkt - 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 - - - Transket_pyr,Transketolase_C,Transketolase_N k59_179190_1 348824.LPU83_2010 1.54e-40 150.0 COG4626@1|root,COG4626@2|Bacteria,1R2FH@1224|Proteobacteria,2UCW2@28211|Alphaproteobacteria,4BCYA@82115|Rhizobiaceae 28211|Alphaproteobacteria S Terminase - - - - - - - - - - - - - k59_857693_1 1229909.NSED_00565 6.42e-08 50.4 COG1522@1|root,arCOG01580@2157|Archaea,41SKI@651137|Thaumarchaeota 651137|Thaumarchaeota K Lrp/AsnC ligand binding domain - - - ko:K03718 - - - - ko00000,ko03000 - - - AsnC_trans_reg,HTH_24 k59_801147_1 1122137.AQXF01000001_gene2523 2.02e-61 199.0 COG4695@1|root,COG4695@2|Bacteria,1MUP5@1224|Proteobacteria,2TT33@28211|Alphaproteobacteria 28211|Alphaproteobacteria S portal protein - - - - - - - - - - - - Phage_portal k59_1704454_2 1238182.C882_0739 1.23e-67 211.0 COG3707@1|root,COG3707@2|Bacteria,1MXDV@1224|Proteobacteria,2U220@28211|Alphaproteobacteria,2JSAN@204441|Rhodospirillales 204441|Rhodospirillales T ANTAR - - - ko:K07183 - - - - ko00000,ko02022 - - - ANTAR,Response_reg k59_1479203_1 1121448.DGI_0830 3.71e-57 202.0 COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,42NCZ@68525|delta/epsilon subdivisions,2WK3X@28221|Deltaproteobacteria,2M9PX@213115|Desulfovibrionales 28221|Deltaproteobacteria P Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K07787 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.6.1.4 - iAF987.Gmet_1547 ACR_tran k59_913649_1 745718.JADT01000004_gene1147 3.41e-31 120.0 COG2373@1|root,COG2373@2|Bacteria,4NED2@976|Bacteroidetes,1HWJJ@117743|Flavobacteriia 976|Bacteroidetes P Large extracellular alpha-helical protein - - - - - - - - - - - - A2M,A2M_N,A2M_N_2,CarbopepD_reg_2 k59_969674_1 240015.ACP_1519 1.37e-163 495.0 COG0587@1|root,COG0587@2|Bacteria,3Y3YK@57723|Acidobacteria,2JKQG@204432|Acidobacteriia 204432|Acidobacteriia L Belongs to the DNA polymerase type-C family. DnaE2 subfamily - - 2.7.7.7 ko:K14162 - - - - ko00000,ko01000,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon k59_461701_1 1246626.BleG1_0647 1.45e-13 72.0 COG0402@1|root,COG0402@2|Bacteria,1TP43@1239|Firmicutes,4HBV3@91061|Bacilli,1ZCH7@1386|Bacillus 91061|Bacilli F Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine - - 3.5.4.28,3.5.4.31 ko:K12960 ko00270,ko01100,map00270,map01100 - R09660 RC00477 ko00000,ko00001,ko01000 - - - Amidohydro_1 k59_461701_2 935548.KI912159_gene4081 3.37e-35 128.0 COG0022@1|root,COG0022@2|Bacteria,1R8KB@1224|Proteobacteria,2TRFK@28211|Alphaproteobacteria,43HIU@69277|Phyllobacteriaceae 28211|Alphaproteobacteria C COG0022 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit - - 1.2.4.1 ko:K00162,ko:K21417 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230 M00307 R00014,R00209,R01699,R03270 RC00004,RC00027,RC00627,RC02742,RC02744,RC02882 br01601,ko00000,ko00001,ko00002,ko01000 - - - Transket_pyr,Transketolase_C k59_1704473_1 319224.Sputcn32_0434 9.01e-42 150.0 COG0304@1|root,COG0304@2|Bacteria,1N91E@1224|Proteobacteria,1RMPP@1236|Gammaproteobacteria,2QAPB@267890|Shewanellaceae 1236|Gammaproteobacteria IQ Belongs to the beta-ketoacyl-ACP synthases family fabF2 - 2.3.1.41 ko:K00647 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119 RC00039,RC02728,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Ketoacyl-synt_C,ketoacyl-synt k59_179219_1 1171373.PACID_07910 0.000258 48.9 COG3291@1|root,COG3291@2|Bacteria,2GN7G@201174|Actinobacteria,4DP00@85009|Propionibacteriales 201174|Actinobacteria S Repeats in polycystic kidney disease 1 (PKD1) and other proteins wcoG - - - - - - - - - - - Laminin_G_3,PKD k59_857718_2 1280947.HY30_05255 5.25e-28 108.0 298YE@1|root,2ZW29@2|Bacteria,1N9JF@1224|Proteobacteria,2UHRA@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_1535166_1 1122137.AQXF01000002_gene19 8.83e-59 202.0 COG5373@1|root,COG5373@2|Bacteria 2|Bacteria KLT membrane - - 2.7.7.7,3.4.21.10 ko:K01317,ko:K02343,ko:K02666 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko01002,ko02035,ko02044,ko03032,ko03400,ko04131 3.A.15.2 - - FecR,LptC,NLPC_P60,Pkinase,SH3_3 k59_179221_1 635013.TherJR_1749 0.000405 44.3 COG4970@1|root,COG4970@2|Bacteria,1U4QW@1239|Firmicutes,25IDV@186801|Clostridia,266MB@186807|Peptococcaceae 186801|Clostridia U TIGRFAM general secretion pathway protein H - - - ko:K08084 - - - - ko00000,ko02044 3.A.15.2 - - N_methyl k59_179221_2 998088.B565_2893 8.34e-32 117.0 COG2165@1|root,COG2165@2|Bacteria,1RDX2@1224|Proteobacteria,1S3VS@1236|Gammaproteobacteria,1Y4JA@135624|Aeromonadales 135624|Aeromonadales U general secretion pathway protein G exeG - - ko:K02456 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - N_methyl,T2SSG k59_179221_3 1487923.DP73_16745 8.57e-11 65.1 COG1459@1|root,COG1459@2|Bacteria,1TQRZ@1239|Firmicutes,249FV@186801|Clostridia,2600P@186807|Peptococcaceae 186801|Clostridia U Type II secretion system - - - ko:K02653 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSF k59_631140_1 1122137.AQXF01000006_gene878 1.53e-114 344.0 COG0642@1|root,COG0642@2|Bacteria,1NXDJ@1224|Proteobacteria 1224|Proteobacteria T Histidine kinase - - 2.7.13.3 ko:K07716,ko:K20974 ko02020,ko02025,ko04112,map02020,map02025,map04112 M00511,M00820 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - CHASE,CHASE3,HATPase_c,HisKA,PAS_7,Response_reg k59_687661_1 158500.BV97_01066 1.72e-93 285.0 COG4638@1|root,COG4638@2|Bacteria,1NSC4@1224|Proteobacteria,2UQBE@28211|Alphaproteobacteria,2K2BM@204457|Sphingomonadales 204457|Sphingomonadales P Ring hydroxylating alpha subunit (catalytic domain) - - - - - - - - - - - - Rieske,Ring_hydroxyl_A k59_517951_1 1088721.NSU_3860 2.08e-33 126.0 COG2234@1|root,COG2234@2|Bacteria,1R88X@1224|Proteobacteria,2U1MC@28211|Alphaproteobacteria,2K3J3@204457|Sphingomonadales 204457|Sphingomonadales S M42 glutamyl aminopeptidase - - - - - - - - - - - - PA,Peptidase_M28 k59_517951_2 702113.PP1Y_AT30600 5.32e-62 203.0 COG0516@1|root,COG0517@1|root,COG0516@2|Bacteria,COG0517@2|Bacteria,1MUJM@1224|Proteobacteria,2TQXC@28211|Alphaproteobacteria,2K0CG@204457|Sphingomonadales 204457|Sphingomonadales F Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth guaB - 1.1.1.205 ko:K00088 ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 M00050 R01130,R08240 RC00143,RC02207 ko00000,ko00001,ko00002,ko01000,ko04147 - - - CBS,IMPDH,NMO k59_1648194_1 702113.PP1Y_AT19311 1.38e-92 297.0 COG0612@1|root,COG0612@2|Bacteria,1NAH6@1224|Proteobacteria,2U0S5@28211|Alphaproteobacteria,2K0RS@204457|Sphingomonadales 204457|Sphingomonadales S Peptidase, M16 - - - ko:K07263 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M16,Peptidase_M16_C k59_687680_1 1209072.ALBT01000031_gene1847 4.15e-77 253.0 COG0187@1|root,COG0187@2|Bacteria,1MVKT@1224|Proteobacteria,1RNB2@1236|Gammaproteobacteria,1FGV1@10|Cellvibrio 1236|Gammaproteobacteria L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrB GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003916,GO:0003918,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006265,GO:0006351,GO:0006725,GO:0006807,GO:0006996,GO:0007059,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009295,GO:0009330,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017076,GO:0017111,GO:0018130,GO:0019438,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032774,GO:0032991,GO:0034335,GO:0034641,GO:0034645,GO:0034654,GO:0035639,GO:0036094,GO:0042221,GO:0042493,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051276,GO:0061505,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0097367,GO:0097659,GO:0140097,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901576 5.99.1.3 ko:K02470 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim k59_292708_1 1074451.CRL705_1045 4.13e-30 117.0 COG1691@1|root,COG1691@2|Bacteria,1TP0Z@1239|Firmicutes,4HBMK@91061|Bacilli,3F526@33958|Lactobacillaceae 91061|Bacilli S AIR carboxylase larB - - ko:K06898 - - - - ko00000 - - - AIRC k59_857746_1 644076.SCH4B_1779 4.88e-07 52.0 COG0330@1|root,COG0330@2|Bacteria,1MUM2@1224|Proteobacteria,2TRTP@28211|Alphaproteobacteria,4NBMN@97050|Ruegeria 28211|Alphaproteobacteria O HflC and HflK could encode or regulate a protease hflK - - ko:K04088 - M00742 - - ko00000,ko00002,ko01000 - - - Band_7,HflK_N k59_857746_2 1089544.KB912942_gene1653 0.000874 45.8 COG0330@1|root,COG0330@2|Bacteria,2GKFP@201174|Actinobacteria 201174|Actinobacteria O PFAM Band 7 protein - - - - - - - - - - - - Band_7 k59_1367072_2 62928.azo0931 3.15e-59 197.0 COG1160@1|root,COG1160@2|Bacteria,1MU9S@1224|Proteobacteria,2VI8D@28216|Betaproteobacteria,2KVNI@206389|Rhodocyclales 206389|Rhodocyclales S GTPase that plays an essential role in the late steps of ribosome biogenesis der - - ko:K03977 - - - - ko00000,ko03009 - - - KH_dom-like,MMR_HSR1 k59_1197375_1 582515.KR51_00009590 3.07e-12 67.4 COG4663@1|root,COG4663@2|Bacteria,1G1BA@1117|Cyanobacteria 1117|Cyanobacteria C Part of the tripartite ATP-independent periplasmic (TRAP) transport system - GO:0003674,GO:0005215,GO:0005342,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006810,GO:0008150,GO:0015849,GO:0022857,GO:0031317,GO:0032991,GO:0036094,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0043177,GO:0044464,GO:0046872,GO:0046983,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:1903825,GO:1990351 - - - - - - - - - - DctP k59_1197375_2 518766.Rmar_2648 1.6e-113 339.0 COG4664@1|root,COG4664@2|Bacteria,4PM5T@976|Bacteroidetes,1FIK6@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes Q Tripartite ATP-independent periplasmic transporter, DctM component - - - - - - - - - - - - DctM k59_462902_1 1150469.RSPPHO_00142 8.03e-25 102.0 COG0226@1|root,COG0226@2|Bacteria,1MUH9@1224|Proteobacteria,2TR1C@28211|Alphaproteobacteria,2JQB9@204441|Rhodospirillales 204441|Rhodospirillales P COG0226 ABC-type phosphate transport system, periplasmic component pstS - - ko:K02040 ko02010,ko02020,ko05152,map02010,map02020,map05152 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - PBP_like_2 k59_462902_2 1150469.RSPPHO_00141 2.52e-63 213.0 COG0573@1|root,COG0573@2|Bacteria,1MVKP@1224|Proteobacteria,2TQU1@28211|Alphaproteobacteria,2JQK1@204441|Rhodospirillales 204441|Rhodospirillales P probably responsible for the translocation of the substrate across the membrane pstC - - ko:K02037 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - BPD_transp_1,DUF3708 k59_802211_2 1123236.KB899377_gene338 7.9e-11 60.8 COG1028@1|root,COG1028@2|Bacteria,1MUEV@1224|Proteobacteria,1RNH2@1236|Gammaproteobacteria,465ZA@72275|Alteromonadaceae 1236|Gammaproteobacteria IQ KR domain phbB - 1.1.1.100,1.1.1.36 ko:K00023,ko:K00059 ko00061,ko00333,ko00630,ko00650,ko00780,ko01040,ko01100,ko01120,ko01130,ko01200,ko01212,map00061,map00333,map00630,map00650,map00780,map01040,map01100,map01120,map01130,map01200,map01212 M00083,M00373,M00572 R01779,R01977,R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00103,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 k59_1254079_1 502025.Hoch_2755 7.16e-80 258.0 COG1508@1|root,COG1508@2|Bacteria,1MW4V@1224|Proteobacteria,42M3C@68525|delta/epsilon subdivisions,2WJ21@28221|Deltaproteobacteria,2YTW6@29|Myxococcales 28221|Deltaproteobacteria K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released rpoN - - ko:K03092 ko02020,ko05111,map02020,map05111 - - - ko00000,ko00001,ko03021 - - - Sigma54_AID,Sigma54_CBD,Sigma54_DBD k59_1028706_1 1112216.JH594426_gene3799 1.55e-75 246.0 COG4584@1|root,COG4584@2|Bacteria,1MWIV@1224|Proteobacteria,2TQKF@28211|Alphaproteobacteria,2K2UN@204457|Sphingomonadales 204457|Sphingomonadales L Integrase core domain - - - - - - - - - - - - rve k59_1367086_1 1255043.TVNIR_3268 1.79e-94 294.0 COG0281@1|root,COG0281@2|Bacteria,1MU0A@1224|Proteobacteria,1RQ11@1236|Gammaproteobacteria,1WX9G@135613|Chromatiales 135613|Chromatiales C PFAM Malic enzyme, NAD binding domain - - 1.1.1.40 ko:K00029 ko00620,ko00710,ko01100,ko01120,ko01200,map00620,map00710,map01100,map01120,map01200 M00169,M00172 R00216 RC00105 ko00000,ko00001,ko00002,ko01000 - - - Malic_M,malic k59_1028709_1 1168065.DOK_16273 1.2e-139 424.0 COG1629@1|root,COG1629@2|Bacteria,COG4771@2|Bacteria,1MUWN@1224|Proteobacteria,1S005@1236|Gammaproteobacteria,1J8XF@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P Outer membrane protein beta-barrel family - - - - - - - - - - - - Plug,TonB_dep_Rec k59_632181_1 1122137.AQXF01000004_gene1831 1.07e-184 541.0 COG0653@1|root,COG0653@2|Bacteria,1MUJZ@1224|Proteobacteria,2TTBF@28211|Alphaproteobacteria 28211|Alphaproteobacteria U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane secA GO:0000166,GO:0002790,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0009306,GO:0009987,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015627,GO:0015628,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032940,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:0098776,GO:1901265,GO:1901363,GO:1904680 - ko:K03070 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4 - - SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW k59_575680_1 1137281.D778_00162 2.44e-116 355.0 COG0855@1|root,COG0855@2|Bacteria,4NE3P@976|Bacteroidetes,1HY58@117743|Flavobacteriia 976|Bacteroidetes P Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) ppk - 2.7.4.1 ko:K00937 ko00190,ko03018,map00190,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - PP_kinase,PP_kinase_C,PP_kinase_N k59_970826_1 1129794.C427_1366 3.33e-40 159.0 COG0596@1|root,COG4206@1|root,COG0596@2|Bacteria,COG4206@2|Bacteria,1QVV2@1224|Proteobacteria,1T4JF@1236|Gammaproteobacteria 1236|Gammaproteobacteria H TonB dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_1197397_1 1121468.AUBR01000012_gene2599 2.63e-139 406.0 COG1804@1|root,COG1804@2|Bacteria,1TP54@1239|Firmicutes,24AFB@186801|Clostridia 186801|Clostridia C CoA-transferase family III - - - - - - - - - - - - CoA_transf_3 k59_1762224_1 866895.HBHAL_4807 2.31e-05 48.9 COG0120@1|root,COG0120@2|Bacteria,1V1DB@1239|Firmicutes,4HFQ7@91061|Bacilli,3NDMT@45667|Halobacillus 91061|Bacilli G Ribose 5-phosphate isomerase A (phosphoriboisomerase A) rpiA - 5.3.1.6 ko:K01807 ko00030,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167,M00580 R01056 RC00434 ko00000,ko00001,ko00002,ko01000 - - - Rib_5-P_isom_A k59_1762224_2 1229909.NSED_00920 1.24e-34 129.0 arCOG08635@1|root,arCOG08635@2157|Archaea,41T54@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1649359_1 984962.XP_009552703.1 4.84e-28 116.0 COG3693@1|root,2S0Y4@2759|Eukaryota,39KY3@33154|Opisthokonta,3Q5BR@4751|Fungi,3V40R@5204|Basidiomycota,228C0@155619|Agaricomycetes,3H82J@355688|Agaricomycetes incertae sedis 4751|Fungi G Glycosyl hydrolase family 10 - - 3.2.1.8 ko:K01181 - - - - ko00000,ko01000 - - - Glyco_hydro_10 k59_11256_1 1229909.NSED_00210 1.53e-91 280.0 COG0252@1|root,arCOG01924@2157|Archaea,41SD7@651137|Thaumarchaeota 651137|Thaumarchaeota J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate gatD - 6.3.5.7 ko:K09482 ko00970,ko01100,map00970,map01100 - R03905 RC00010 ko00000,ko00001,ko01000 - - - Asparaginase k59_462935_2 439292.Bsel_1942 3.61e-16 80.5 COG1680@1|root,COG1680@2|Bacteria,1VRUW@1239|Firmicutes,4HTF4@91061|Bacilli 91061|Bacilli V Beta-lactamase - - - - - - - - - - - - Beta-lactamase k59_180386_1 1120950.KB892731_gene3787 4.35e-42 149.0 COG4122@1|root,COG4122@2|Bacteria,2IARG@201174|Actinobacteria,4DST0@85009|Propionibacteriales 201174|Actinobacteria S Macrocin-O-methyltransferase (TylF) - - - ko:K05303 - - - - ko00000,ko01000 - - - TylF k59_462945_1 305900.GV64_09075 1.53e-32 127.0 COG2355@1|root,COG2355@2|Bacteria,1MWEW@1224|Proteobacteria,1RPBD@1236|Gammaproteobacteria,1XI79@135619|Oceanospirillales 135619|Oceanospirillales E Peptidase M19 - - - - - - - - - - - - Peptidase_M19 k59_236652_1 395964.KE386496_gene66 3.56e-61 190.0 COG3293@1|root,COG3293@2|Bacteria,1RKZ9@1224|Proteobacteria,2UAD3@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Putative transposase of IS4/5 family (DUF4096) - - - - - - - - - - - - DUF4096 k59_236652_2 1247963.JPHU01000034_gene1 2.38e-05 45.8 COG2801@1|root,COG2801@2|Bacteria,1QYY9@1224|Proteobacteria,2TY18@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Transposase DDE domain - - - - - - - - - - - - DDE_Tnp_1_2 k59_1140699_1 1122137.AQXF01000002_gene134 4.22e-150 425.0 COG0052@1|root,COG0052@2|Bacteria,1MU33@1224|Proteobacteria,2TRXE@28211|Alphaproteobacteria 28211|Alphaproteobacteria J Belongs to the universal ribosomal protein uS2 family rpsB GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02967 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S2 k59_1140699_2 1122137.AQXF01000002_gene133 2.75e-101 301.0 COG0494@1|root,COG0494@2|Bacteria,1NTFG@1224|Proteobacteria,2U0I4@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Hydrolase MA20_35615 - - - - - - - - - - - NUDIX k59_1140699_3 1122137.AQXF01000002_gene132 5.58e-15 73.9 COG0587@1|root,COG0587@2|Bacteria,1MUIF@1224|Proteobacteria,2TSCN@28211|Alphaproteobacteria 28211|Alphaproteobacteria L DNA polymerase III alpha subunit dnaE GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0050896,GO:0051716,GO:0071496 2.7.7.7 ko:K02337 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon k59_1310554_1 356851.JOAN01000003_gene1437 1.4e-15 75.5 2BAD0@1|root,323TF@2|Bacteria,2H8IH@201174|Actinobacteria,4DJY8@85008|Micromonosporales 201174|Actinobacteria - - - - - - - - - - - - - - - k59_462953_1 1528106.JRJE01000005_gene1315 2.03e-16 78.2 COG1573@1|root,COG1573@2|Bacteria,1MWX1@1224|Proteobacteria,2TT4Q@28211|Alphaproteobacteria,2JRPG@204441|Rhodospirillales 204441|Rhodospirillales L Uracil-DNA glycosylase - - 3.2.2.27 ko:K21929 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - UDG k59_462953_2 1397666.RS24_01309 1.78e-26 110.0 COG0741@1|root,COG0741@2|Bacteria,1MV3F@1224|Proteobacteria,2U35U@28211|Alphaproteobacteria,4BPNI@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria M Transglycosylase SLT domain - - - - - - - - - - - - SLT k59_1480502_1 1229909.NSED_01805 3.56e-108 336.0 COG0013@1|root,arCOG01255@2157|Archaea,41SBJ@651137|Thaumarchaeota 651137|Thaumarchaeota J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain alaS - 6.1.1.7 ko:K01872 ko00970,map00970 M00359,M00360 R03038 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DHHA1,tRNA-synt_2c,tRNA_SAD k59_914826_1 436308.Nmar_0249 5.46e-30 125.0 COG0642@1|root,arCOG02358@2157|Archaea,41T5G@651137|Thaumarchaeota 651137|Thaumarchaeota T PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - HATPase_c,HisKA,dCache_1 k59_1367128_1 555779.Dthio_PD1979 2.79e-44 155.0 COG0004@1|root,COG0004@2|Bacteria,1NR9F@1224|Proteobacteria,42M8M@68525|delta/epsilon subdivisions,2WJE2@28221|Deltaproteobacteria,2M80K@213115|Desulfovibrionales 28221|Deltaproteobacteria P TIGRFAM Ammonium transporter - - - ko:K03320 - - - - ko00000,ko02000 1.A.11 - - Ammonium_transp k59_1367128_2 1415778.JQMM01000001_gene147 8.43e-57 179.0 COG0347@1|root,COG0347@2|Bacteria,1RGWK@1224|Proteobacteria,1S67I@1236|Gammaproteobacteria,1J6F3@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria K Belongs to the P(II) protein family glnK - - ko:K04751,ko:K04752 ko02020,map02020 - - - ko00000,ko00001 - - - P-II k59_1705580_1 1278073.MYSTI_06096 5.55e-53 185.0 COG0277@1|root,COG0277@2|Bacteria,1MXTV@1224|Proteobacteria,42RXR@68525|delta/epsilon subdivisions,2WNHV@28221|Deltaproteobacteria 28221|Deltaproteobacteria C PFAM FAD linked oxidase domain protein - - 2.5.1.26 ko:K00803 ko00565,ko01100,ko04146,map00565,map01100,map04146 - R04311 RC00020,RC02886 ko00000,ko00001,ko01000 - - - FAD-oxidase_C,FAD_binding_4 k59_970890_1 1254432.SCE1572_00290 2.28e-68 228.0 COG0517@1|root,COG0517@2|Bacteria,1QZT1@1224|Proteobacteria,43CN4@68525|delta/epsilon subdivisions,2X7VC@28221|Deltaproteobacteria,2Z3IG@29|Myxococcales 28221|Deltaproteobacteria S Domain in cystathionine beta-synthase and other proteins. - - - - - - - - - - - - CBS k59_462955_1 247490.KSU1_D0675 4.17e-22 101.0 COG1012@1|root,COG1012@2|Bacteria,2IX0I@203682|Planctomycetes 203682|Planctomycetes C Belongs to the aldehyde dehydrogenase family - - 1.2.1.18,1.2.1.27 ko:K00140 ko00280,ko00410,ko00562,ko00640,ko01100,ko01200,map00280,map00410,map00562,map00640,map01100,map01200 M00013 R00705,R00706,R00922,R00935 RC00004,RC02723,RC02817 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_688898_1 998674.ATTE01000001_gene237 9.83e-10 62.0 COG0654@1|root,COG0654@2|Bacteria,1MU6I@1224|Proteobacteria,1RMS3@1236|Gammaproteobacteria,45ZU3@72273|Thiotrichales 72273|Thiotrichales CH Ubiquinone biosynthesis hydroxylase, UbiH UbiF VisC COQ6 - - - ko:K03185 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00117 R04989,R08773 RC02670 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_3 k59_688898_2 1121374.KB891575_gene1616 6.82e-48 164.0 COG0006@1|root,COG0006@2|Bacteria,1MUZS@1224|Proteobacteria,1RN0W@1236|Gammaproteobacteria 1236|Gammaproteobacteria E aminopeptidase pepP - 3.4.11.9 ko:K01262 - - - - ko00000,ko01000,ko01002 - - - AMP_N,Peptidase_M24 k59_1649395_1 305700.B447_10353 2.27e-26 100.0 COG1977@1|root,COG1977@2|Bacteria,1N0IE@1224|Proteobacteria,2VVSP@28216|Betaproteobacteria,2KX9K@206389|Rhodocyclales 206389|Rhodocyclales H Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin moaD - - ko:K03636 ko04122,map04122 - - - ko00000,ko00001 - - - ThiS k59_1649395_2 666684.AfiDRAFT_3805 2.32e-28 107.0 COG1763@1|root,COG1763@2|Bacteria,1RD3Q@1224|Proteobacteria,2U5T0@28211|Alphaproteobacteria,3JSEJ@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria H Molybdopterin guanine dinucleotide synthesis protein B mobB GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0005488,GO:0005525,GO:0017076,GO:0019001,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - ko:K03753 - - - - ko00000 - - - MobB k59_1705581_1 477184.KYC_12193 2.51e-59 197.0 COG1804@1|root,COG1804@2|Bacteria,1NSWZ@1224|Proteobacteria 1224|Proteobacteria C Dehydratase - - 2.8.3.15 ko:K07544 ko00623,ko01100,ko01120,ko01220,map00623,map01100,map01120,map01220 M00418 R05588 RC00014,RC00137 ko00000,ko00001,ko00002,ko01000 - - - CoA_transf_3 k59_859003_1 1229172.JQFA01000002_gene4768 7.88e-26 108.0 COG4638@1|root,COG4638@2|Bacteria,1G4T7@1117|Cyanobacteria,1HA75@1150|Oscillatoriales 1117|Cyanobacteria P COG4638 Phenylpropionate dioxygenase and related ring-hydroxylating - - - - - - - - - - - - Rieske k59_301587_1 1163389.OOM_0219 9.67e-28 111.0 COG0480@1|root,COG0480@2|Bacteria,1MUCV@1224|Proteobacteria,1RNSZ@1236|Gammaproteobacteria,46061@72273|Thiotrichales 72273|Thiotrichales J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome fusA - - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2 k59_752683_1 1122137.AQXF01000007_gene3482 4.46e-103 308.0 COG2866@1|root,COG2866@2|Bacteria,1MUMN@1224|Proteobacteria,2TREN@28211|Alphaproteobacteria 28211|Alphaproteobacteria E carboxypeptidase - - - - - - - - - - - - Peptidase_M14 k59_752683_2 412597.AEPN01000016_gene1192 1.22e-08 55.1 COG0503@1|root,COG0503@2|Bacteria,1MVZ6@1224|Proteobacteria,2TV7J@28211|Alphaproteobacteria,2PUIS@265|Paracoccus 28211|Alphaproteobacteria F Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis apt - 2.4.2.7 ko:K00759 ko00230,ko01100,map00230,map01100 - R00190,R01229,R04378 RC00063 ko00000,ko00001,ko01000,ko04147 - - - Pribosyltran k59_1260948_1 1122135.KB893157_gene168 5.56e-64 211.0 COG4664@1|root,COG4664@2|Bacteria,1R4MZ@1224|Proteobacteria,2TQNR@28211|Alphaproteobacteria 28211|Alphaproteobacteria Q TRAP-type mannitol chloroaromatic compound transport system large permease component - - - - - - - - - - - - DctM k59_1260948_2 1122201.AUAZ01000009_gene2763 4.81e-17 78.6 COG4665@1|root,COG4665@2|Bacteria,1RE14@1224|Proteobacteria,1S582@1236|Gammaproteobacteria,46AGS@72275|Alteromonadaceae 1236|Gammaproteobacteria Q Tripartite ATP-independent periplasmic transporters, DctQ component - - - - - - - - - - - - DctQ k59_696158_1 585531.HMPREF0063_10065 2.45e-74 238.0 COG4626@1|root,COG4626@2|Bacteria,2GNSB@201174|Actinobacteria,4DTXN@85009|Propionibacteriales 201174|Actinobacteria S Terminase - - - - - - - - - - - - - k59_1037346_1 767434.Fraau_0171 7.41e-51 174.0 COG0500@1|root,COG2226@2|Bacteria,1PA5F@1224|Proteobacteria,1RY7A@1236|Gammaproteobacteria,1X53I@135614|Xanthomonadales 135614|Xanthomonadales H Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway bioC - 2.1.1.197 ko:K02169 ko00780,ko01100,map00780,map01100 M00572 R09543 RC00003,RC00460 ko00000,ko00001,ko00002,ko01000 - - - Methyltransf_11 k59_640791_2 1229909.NSED_05735 3.76e-65 202.0 COG0589@1|root,arCOG02053@2157|Archaea,41TB2@651137|Thaumarchaeota 651137|Thaumarchaeota T COG0589 Universal stress protein UspA and related nucleotide-binding proteins - - - - - - - - - - - - Usp k59_19469_1 1298867.AUES01000002_gene1380 4.26e-75 241.0 COG2303@1|root,COG2303@2|Bacteria,1MV19@1224|Proteobacteria,2TQKQ@28211|Alphaproteobacteria,3JSS3@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria E GMC oxidoreductase - - 1.1.99.1 ko:K00108 ko00260,ko01100,map00260,map01100 M00555 R01025 RC00087 ko00000,ko00001,ko00002,ko01000 - - - GMC_oxred_C,GMC_oxred_N k59_697174_1 1229909.NSED_02215 2.51e-61 192.0 COG0102@1|root,arCOG04242@2157|Archaea,41SP4@651137|Thaumarchaeota 651137|Thaumarchaeota J This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly rpl13 - - ko:K02871 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L13 k59_697174_2 1229909.NSED_02220 6.06e-53 167.0 COG1727@1|root,arCOG00780@2157|Archaea,41SRE@651137|Thaumarchaeota 651137|Thaumarchaeota J ribosomal protein - - - ko:K02883 ko03010,map03010 M00177,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L18 k59_1488832_2 402777.KB235903_gene2078 5.76e-14 75.9 COG0642@1|root,COG2199@1|root,COG2205@2|Bacteria,COG3706@2|Bacteria,1GDIS@1117|Cyanobacteria,1HHSX@1150|Oscillatoriales 1117|Cyanobacteria T diguanylate cyclase (GGDEF domain) - - - - - - - - - - - - CHASE,EAL,GAF,GGDEF,PAS,PAS_4,PAS_9,Response_reg k59_1037358_1 1134912.AJTV01000014_gene279 3.04e-27 108.0 COG2710@1|root,COG2710@2|Bacteria,1MVY2@1224|Proteobacteria,2TU8M@28211|Alphaproteobacteria,36ZIG@31993|Methylocystaceae 28211|Alphaproteobacteria C Nitrogenase component 1 type Oxidoreductase nifD - 1.18.6.1 ko:K02586 ko00625,ko00910,ko01100,ko01120,map00625,map00910,map01100,map01120 M00175 R05185,R05496 RC00002,RC01395,RC02891 ko00000,ko00001,ko00002,ko01000 - - - Oxidored_nitro k59_1037358_2 663610.JQKO01000002_gene1195 6.08e-106 320.0 COG2710@1|root,COG2710@2|Bacteria,1MWQ4@1224|Proteobacteria,2TT37@28211|Alphaproteobacteria,3N9Q9@45404|Beijerinckiaceae 28211|Alphaproteobacteria C This molybdenum-iron protein is part of the nitrogenase complex that catalyzes the key enzymatic reactions in nitrogen fixation nifK - 1.18.6.1 ko:K02591 ko00625,ko00910,ko01100,ko01120,map00625,map00910,map01100,map01120 M00175 R05185,R05496 RC00002,RC01395,RC02891 ko00000,ko00001,ko00002,ko01000 - - - DUF3364,Oxidored_nitro k59_584012_1 1122194.AUHU01000012_gene391 2.1e-41 152.0 COG3712@1|root,COG3712@2|Bacteria,1PN9U@1224|Proteobacteria,1RRFX@1236|Gammaproteobacteria,466BK@72275|Alteromonadaceae 1236|Gammaproteobacteria PT Concanavalin A-like lectin/glucanases superfamily - - - - - - - - - - - - FecR,Laminin_G_3 k59_1713968_1 472759.Nhal_1928 2.71e-109 320.0 COG1045@1|root,COG1045@2|Bacteria,1MVFX@1224|Proteobacteria,1RNCA@1236|Gammaproteobacteria,1WW81@135613|Chromatiales 135613|Chromatiales E TIGRFAM Serine O-acetyltransferase - - 2.3.1.30 ko:K00640 ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111 M00021 R00586 RC00004,RC00041 ko00000,ko00001,ko00002,ko01000 - - - Hexapep,SATase_N k59_1037367_1 672.VV93_v1c42870 4.1e-06 47.4 COG3439@1|root,COG3439@2|Bacteria,1RH9Z@1224|Proteobacteria 1224|Proteobacteria S Domain of unknown function DUF302 - - - - - - - - - - - - DUF302 k59_1037367_2 1205753.A989_10440 9.68e-32 115.0 COG0640@1|root,COG0640@2|Bacteria,1N72Q@1224|Proteobacteria,1SCH5@1236|Gammaproteobacteria,1X7P3@135614|Xanthomonadales 135614|Xanthomonadales K transcriptional - - - - - - - - - - - - HTH_5 k59_867593_2 1288494.EBAPG3_25250 1.01e-30 112.0 COG2165@1|root,COG2165@2|Bacteria,1N0C2@1224|Proteobacteria,2VVJ8@28216|Betaproteobacteria,374BR@32003|Nitrosomonadales 28216|Betaproteobacteria NU Type II secretion system (T2SS), protein I gspI - - ko:K02458 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - N_methyl,T2SSI k59_19492_1 1515746.HR45_01130 1.45e-82 258.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,2Q9RH@267890|Shewanellaceae 1236|Gammaproteobacteria T Two component, sigma54 specific, transcriptional regulator, Fis family - - - ko:K02481 - - - - ko00000,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_867616_1 1121374.KB891576_gene250 1.86e-26 111.0 COG0642@1|root,COG0642@2|Bacteria,1QU3Z@1224|Proteobacteria,1T311@1236|Gammaproteobacteria 1236|Gammaproteobacteria T Histidine kinase - - - - - - - - - - - - CBM9_1,HATPase_c,HisKA k59_923334_1 1232410.KI421418_gene2112 1.23e-79 246.0 COG0158@1|root,COG0158@2|Bacteria,1MW0E@1224|Proteobacteria,42NRA@68525|delta/epsilon subdivisions,2WJ62@28221|Deltaproteobacteria,43TID@69541|Desulfuromonadales 28221|Deltaproteobacteria G D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 fbp GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005984,GO:0005985,GO:0005986,GO:0005996,GO:0006000,GO:0006002,GO:0006006,GO:0006094,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009058,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019203,GO:0019318,GO:0019319,GO:0019637,GO:0030388,GO:0034637,GO:0042132,GO:0042578,GO:0044237,GO:0044238,GO:0044249,GO:0044262,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046351,GO:0046364,GO:0050308,GO:0071704,GO:1901135,GO:1901576 3.1.3.11 ko:K03841 ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko04152,ko04910,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map04152,map04910 M00003,M00165,M00167,M00344 R00762,R04780 RC00017 ko00000,ko00001,ko00002,ko01000,ko04147 - - - FBPase k59_640828_1 1122137.AQXF01000001_gene3096 2.87e-27 103.0 COG1872@1|root,COG1872@2|Bacteria,1N6V2@1224|Proteobacteria,2UF67@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Belongs to the UPF0235 family MA20_25230 - - ko:K09131 - - - - ko00000 - - - DUF167 k59_640828_2 1122137.AQXF01000001_gene3095 1.69e-71 223.0 COG0190@1|root,COG0190@2|Bacteria,1MWU4@1224|Proteobacteria,2TRZZ@28211|Alphaproteobacteria 28211|Alphaproteobacteria F Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate folD - 1.5.1.5,3.5.4.9 ko:K01491 ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200 M00140,M00377 R01220,R01655 RC00202,RC00578 ko00000,ko00001,ko00002,ko01000 - - - THF_DHG_CYH,THF_DHG_CYH_C k59_867632_1 1380391.JIAS01000013_gene3841 1.55e-47 162.0 COG0730@1|root,COG0730@2|Bacteria,1RDKW@1224|Proteobacteria,2TQP3@28211|Alphaproteobacteria,2JSF0@204441|Rhodospirillales 204441|Rhodospirillales S Sulfite exporter TauE/SafE - - - - - - - - - - - - TauE k59_132441_1 436308.Nmar_0193 4.61e-68 221.0 COG0527@1|root,arCOG00861@2157|Archaea,41SFK@651137|Thaumarchaeota 651137|Thaumarchaeota E Amino acid kinase family - - 2.7.2.4 ko:K00928 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00017,M00018,M00033,M00525,M00526,M00527 R00480 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase k59_810827_1 1454004.AW11_00314 1.15e-72 244.0 COG0046@1|root,COG0047@1|root,COG0046@2|Bacteria,COG0047@2|Bacteria,1MYN4@1224|Proteobacteria,2VHTE@28216|Betaproteobacteria,1KPW6@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria F Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate purL GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004642,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0017076,GO:0018130,GO:0019438,GO:0019637,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046872,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.3.5.3 ko:K01952 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04463 RC00010,RC01160 ko00000,ko00001,ko00002,ko01000 - - - AIRS_C,GATase_5 k59_640834_1 316407.85676525 5.48e-36 133.0 COG1626@1|root,COG1626@2|Bacteria,1MWSM@1224|Proteobacteria,1RMFP@1236|Gammaproteobacteria,3XMAI@561|Escherichia 1236|Gammaproteobacteria G Hydrolyzes trehalose to glucose. Could be involved, in cells returning to low osmolarity conditions, in the utilization of the accumulated cytoplasmic trehalose, which was synthesized in response to high osmolarity treF GO:0003674,GO:0003824,GO:0004553,GO:0004555,GO:0005575,GO:0005623,GO:0005975,GO:0005984,GO:0005991,GO:0005993,GO:0006950,GO:0006970,GO:0006972,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009311,GO:0009313,GO:0009628,GO:0009987,GO:0015927,GO:0016052,GO:0016787,GO:0016798,GO:0030288,GO:0030313,GO:0031975,GO:0033554,GO:0042597,GO:0044237,GO:0044238,GO:0044248,GO:0044262,GO:0044275,GO:0044464,GO:0046352,GO:0050896,GO:0051716,GO:0071214,GO:0071470,GO:0071474,GO:0071704,GO:0104004,GO:1901575 3.2.1.28 ko:K01194 ko00500,ko01100,map00500,map01100 - R00010 RC00049 ko00000,ko00001,ko00537,ko01000 - GH37 iAF1260.b1197,iB21_1397.B21_01182,iBWG_1329.BWG_1022,iECBD_1354.ECBD_2425,iECB_1328.ECB_01172,iECDH10B_1368.ECDH10B_1250,iECDH1ME8569_1439.ECDH1ME8569_1136,iECD_1391.ECD_01172,iETEC_1333.ETEC_1301,iEcDH1_1363.EcDH1_2451,iEcHS_1320.EcHS_A1301,iEcolC_1368.EcolC_2429,iJO1366.b1197,iJR904.b1197,iSBO_1134.SBO_3518,iY75_1357.Y75_RS06245 Trehalase k59_584072_1 1265313.HRUBRA_00252 1.69e-110 332.0 COG2170@1|root,COG2170@2|Bacteria,1MXET@1224|Proteobacteria,1RPKZ@1236|Gammaproteobacteria,1J4M1@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S glutamate--cysteine ligase - - - - - - - - - - - - GCS2 k59_245045_1 246197.MXAN_0621 1.8e-23 95.1 COG3382@1|root,COG3382@2|Bacteria,1N6A7@1224|Proteobacteria,4337M@68525|delta/epsilon subdivisions,2WXR0@28221|Deltaproteobacteria,2YUZ2@29|Myxococcales 28221|Deltaproteobacteria S B3/4 domain - - - - - - - - - - - - B3_4 k59_697220_1 1122137.AQXF01000001_gene3405 1.03e-100 310.0 COG5010@1|root,COG5010@2|Bacteria,1RK9P@1224|Proteobacteria,2U5CI@28211|Alphaproteobacteria 28211|Alphaproteobacteria U Sporulation related domain - - - - - - - - - - - - SPOR,TPR_16,TPR_19,TPR_4 k59_923359_1 763034.HMPREF9446_00437 3.72e-81 257.0 COG3344@1|root,COG3344@2|Bacteria,4NGGU@976|Bacteroidetes,2G2I8@200643|Bacteroidia,4AVZB@815|Bacteroidaceae 976|Bacteroidetes H Group II intron, maturase-specific domain - - 2.7.7.49 ko:K00986 - - - - ko00000,ko01000 - - - GIIM,HNH,Intron_maturas2,RVT_1,RVT_N k59_1601200_1 396588.Tgr7_0944 5.56e-114 338.0 COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,1RMAQ@1236|Gammaproteobacteria,1WXTC@135613|Chromatiales 135613|Chromatiales L transposase IS116 IS110 IS902 family - - - ko:K07486 - - - - ko00000 - - - DEDD_Tnp_IS110,Transposase_20 k59_1092542_1 655815.ZPR_3629 1.15e-24 97.8 COG1648@1|root,COG1648@2|Bacteria,4NI81@976|Bacteroidetes,1HYI1@117743|Flavobacteriia 976|Bacteroidetes H COG1648 Siroheme synthase (precorrin-2 oxidase ferrochelatase domain) cysG - 1.3.1.76,4.99.1.4 ko:K02304,ko:K07090 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R02864,R03947 RC01012,RC01034 ko00000,ko00001,ko00002,ko01000 - - - NAD_binding_7,Sirohm_synth_M,TauE k59_1092542_2 411154.GFO_0330 5.25e-81 249.0 COG0492@1|root,COG0492@2|Bacteria,4NEQM@976|Bacteroidetes,1HWUC@117743|Flavobacteriia 976|Bacteroidetes C Ferredoxin--NADP reductase trxB2 - 1.8.1.9 ko:K00384 ko00450,map00450 - R02016,R03596,R09372 RC00013,RC02518,RC02873 ko00000,ko00001,ko01000 - - - Pyr_redox_2 k59_358992_1 1122137.AQXF01000002_gene129 3.6e-127 373.0 COG0442@1|root,COG0442@2|Bacteria,1MU7E@1224|Proteobacteria,2TQQ4@28211|Alphaproteobacteria 28211|Alphaproteobacteria J Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) proS GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 6.1.1.15 ko:K01881 ko00970,map00970 M00359,M00360 R03661 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,tRNA-synt_2b k59_867667_1 627192.SLG_26890 1.09e-31 130.0 COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,1R6VI@1224|Proteobacteria,2U4V7@28211|Alphaproteobacteria,2K029@204457|Sphingomonadales 204457|Sphingomonadales EU Prolyl oligopeptidase family - - - - - - - - - - - - PD40,Peptidase_S9 k59_1714003_2 338963.Pcar_2211 4.07e-06 47.0 COG2001@1|root,COG2001@2|Bacteria,1RHCG@1224|Proteobacteria,42TRZ@68525|delta/epsilon subdivisions,2WQRI@28221|Deltaproteobacteria,43SN1@69541|Desulfuromonadales 28221|Deltaproteobacteria K MraZ protein, putative antitoxin-like mraZ GO:0000976,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031333,GO:0043254,GO:0043565,GO:0044087,GO:0044212,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051129,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2000142,GO:2000143,GO:2001141 - ko:K03925 - - - - ko00000 - - - MraZ k59_810848_1 420324.KI912086_gene7356 4.71e-17 78.6 COG1225@1|root,COG1225@2|Bacteria,1N86B@1224|Proteobacteria,2TVN1@28211|Alphaproteobacteria 28211|Alphaproteobacteria O AhpC/TSA family - - - - - - - - - - - - AhpC-TSA k59_810848_2 420324.KI912086_gene7356 2.66e-33 122.0 COG1225@1|root,COG1225@2|Bacteria,1N86B@1224|Proteobacteria,2TVN1@28211|Alphaproteobacteria 28211|Alphaproteobacteria O AhpC/TSA family - - - - - - - - - - - - AhpC-TSA k59_1601225_1 377629.TERTU_3485 1.29e-86 286.0 COG0439@1|root,COG1984@1|root,COG2049@1|root,COG0439@2|Bacteria,COG1984@2|Bacteria,COG2049@2|Bacteria,1MU4H@1224|Proteobacteria,1T1GN@1236|Gammaproteobacteria,2PMW8@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria EI Pfam:AHS1 uca - 6.3.4.6 ko:K01941 ko00220,ko00791,ko01100,map00220,map00791,map01100 - R00774 RC00378 ko00000,ko00001,ko01000 - - - Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2,CT_A_B,CT_C_D k59_1375819_1 316407.1742764 1.45e-114 332.0 COG0396@1|root,COG0396@2|Bacteria,1MUGK@1224|Proteobacteria,1RPFE@1236|Gammaproteobacteria,3XNS8@561|Escherichia 1236|Gammaproteobacteria P Has low ATPase activity. The SufBCD complex acts synergistically with SufE to stimulate the cysteine desulfurase activity of SufS. The SufBCD complex contributes to the assembly or repair of oxygen-labile iron-sulfur clusters under oxidative stress. May facilitate iron uptake from extracellular iron chelators under iron limitation sufC GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006790,GO:0008150,GO:0008152,GO:0009314,GO:0009628,GO:0009987,GO:0016043,GO:0016226,GO:0022607,GO:0031163,GO:0044085,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051186,GO:0071840 - ko:K09013 - - - - ko00000,ko02000 - - iECH74115_1262.ECH74115_2396,iECIAI1_1343.ECIAI1_1734,iECIAI39_1322.ECIAI39_1376,iECSP_1301.ECSP_2249,iECs_1301.ECs2389,iEcSMS35_1347.EcSMS35_1514,iG2583_1286.G2583_2077,iSFV_1184.SFV_1705,iSFxv_1172.SFxv_1919,iSSON_1240.SSON_1474,iS_1188.S1844,iZ_1308.Z2710 ABC_tran k59_978847_2 443144.GM21_3843 1.74e-08 55.5 COG1706@1|root,COG1706@2|Bacteria,1MVKW@1224|Proteobacteria,42MAU@68525|delta/epsilon subdivisions,2WK22@28221|Deltaproteobacteria,43TZ1@69541|Desulfuromonadales 28221|Deltaproteobacteria N Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation flgI - - ko:K02394 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - FlgI k59_810849_1 1249627.D779_2413 1.28e-96 297.0 COG0539@1|root,COG0539@2|Bacteria,1MVAV@1224|Proteobacteria,1RMFY@1236|Gammaproteobacteria,1WVVK@135613|Chromatiales 135613|Chromatiales J thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence rpsA - - ko:K02945 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - S1 k59_359014_2 1111479.AXAR01000007_gene902 2.5e-05 45.8 COG3027@1|root,COG3027@2|Bacteria 2|Bacteria D Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division zapA - - ko:K09888 - - - - ko00000,ko03036 - - - ZapA k59_697246_1 436308.Nmar_1408 5.65e-122 365.0 COG1389@1|root,arCOG01165@2157|Archaea,41SJ2@651137|Thaumarchaeota 651137|Thaumarchaeota L Relaxes both positive and negative superturns and exhibits a strong decatenase activity top6B - 5.99.1.3 ko:K03167 - - - - ko00000,ko01000,ko03032 - - - HATPase_c,Topo-VIb_trans k59_697246_2 436308.Nmar_1409 8.83e-104 303.0 COG1094@1|root,arCOG04150@2157|Archaea,41SNG@651137|Thaumarchaeota 651137|Thaumarchaeota J K homology RNA-binding domain - - - ko:K06961 - - - - ko00000,ko03009 - - - KH_1 k59_923388_1 1112212.JH584235_gene3219 2.45e-12 66.6 COG4221@1|root,COG4221@2|Bacteria,1MUF8@1224|Proteobacteria,2TR5S@28211|Alphaproteobacteria,2K1R4@204457|Sphingomonadales 204457|Sphingomonadales S Belongs to the short-chain dehydrogenases reductases (SDR) family - - 1.1.1.276 ko:K05886 - - - - ko00000,ko01000 - - - adh_short k59_923388_2 1144305.PMI02_04969 6.05e-39 139.0 COG2017@1|root,COG2017@2|Bacteria,1MVR4@1224|Proteobacteria,2TZZR@28211|Alphaproteobacteria,2K0MD@204457|Sphingomonadales 204457|Sphingomonadales G Aldose 1-epimerase - - - - - - - - - - - - Aldose_epim k59_1601229_1 1096930.L284_04180 9.51e-62 196.0 COG1309@1|root,COG1309@2|Bacteria,1MZ9E@1224|Proteobacteria,2U0MU@28211|Alphaproteobacteria,2K4G0@204457|Sphingomonadales 204457|Sphingomonadales K Transcriptional regulator - - - - - - - - - - - - TetR_C_11,TetR_C_7,TetR_N k59_1205757_1 1123279.ATUS01000002_gene55 4.08e-60 189.0 COG1610@1|root,COG1610@2|Bacteria,1RGZS@1224|Proteobacteria,1S61A@1236|Gammaproteobacteria,1J67Q@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Yqey-like protein lporfX - - ko:K09117 - - - - ko00000 - - - YqeY k59_1148983_1 1121374.KB891588_gene3296 7.55e-31 125.0 COG0591@1|root,COG0784@1|root,COG4191@1|root,COG0591@2|Bacteria,COG0784@2|Bacteria,COG4191@2|Bacteria,1QTSW@1224|Proteobacteria,1T1G2@1236|Gammaproteobacteria 1236|Gammaproteobacteria T COG0591 Na proline symporter - - - - - - - - - - - - HATPase_c,HisKA,PAS_4,PAS_7,Response_reg,SSF k59_1319111_1 1178825.ALIH01000001_gene2570 1.75e-49 181.0 COG2373@1|root,COG2373@2|Bacteria,4NED2@976|Bacteroidetes,1HWJJ@117743|Flavobacteriia 976|Bacteroidetes P Large extracellular alpha-helical protein - - - - - - - - - - - - A2M,A2M_N,A2M_N_2,CarbopepD_reg_2 k59_359026_1 1122137.AQXF01000002_gene602 2.53e-89 266.0 COG3216@1|root,COG3216@2|Bacteria,1QA1I@1224|Proteobacteria,2TS9W@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Protein conserved in bacteria - - - ko:K09928 - - - - ko00000 - - - DUF2062 k59_359026_2 1122137.AQXF01000002_gene601 1.36e-30 113.0 COG0854@1|root,COG0854@2|Bacteria,1MU9W@1224|Proteobacteria,2TTTF@28211|Alphaproteobacteria 28211|Alphaproteobacteria H Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate pdxJ GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008614,GO:0008615,GO:0009058,GO:0009110,GO:0009987,GO:0016740,GO:0016769,GO:0017144,GO:0018130,GO:0019438,GO:0033856,GO:0034641,GO:0042364,GO:0042816,GO:0042819,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072524,GO:0072525,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 2.6.99.2 ko:K03474 ko00750,ko01100,map00750,map01100 M00124 R05838 RC01476 ko00000,ko00001,ko00002,ko01000 - - - PdxJ k59_19569_1 1349767.GJA_5142 3.15e-51 177.0 COG0732@1|root,COG0732@2|Bacteria,1R42B@1224|Proteobacteria,2VK3X@28216|Betaproteobacteria 28216|Betaproteobacteria L Restriction modification system DNA specificity domain - - 3.1.21.3 ko:K01154 - - - - ko00000,ko01000,ko02048 - - - Methylase_S k59_1375841_1 236097.ADG881_2558 4.09e-53 175.0 COG0408@1|root,COG0408@2|Bacteria,1MWMF@1224|Proteobacteria,1RMM8@1236|Gammaproteobacteria,1XIDG@135619|Oceanospirillales 135619|Oceanospirillales H Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX hemF GO:0003674,GO:0005488,GO:0005515,GO:0042802,GO:0042803,GO:0046983 1.3.3.3 ko:K00228 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R03220 RC00884 ko00000,ko00001,ko00002,ko01000 - - - Coprogen_oxidas k59_1770678_1 1121374.KB891586_gene2678 2.48e-13 68.6 COG0320@1|root,COG0320@2|Bacteria,1MVRD@1224|Proteobacteria,1RMAT@1236|Gammaproteobacteria 1236|Gammaproteobacteria H Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives lipA GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009106,GO:0009107,GO:0009108,GO:0009249,GO:0009987,GO:0010467,GO:0016053,GO:0016740,GO:0016782,GO:0016783,GO:0016992,GO:0018065,GO:0018130,GO:0018193,GO:0018205,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0051604,GO:0070283,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901576 2.8.1.8 ko:K03644 ko00785,ko01100,map00785,map01100 - R07767,R07768 RC01978 ko00000,ko00001,ko01000 - - iAPECO1_1312.APECO1_1427,iB21_1397.B21_00586,iBWG_1329.BWG_0499,iE2348C_1286.E2348C_0528,iEC55989_1330.EC55989_0620,iECABU_c1320.ECABU_c06820,iECBD_1354.ECBD_3023,iECB_1328.ECB_00597,iECDH10B_1368.ECDH10B_0589,iECDH1ME8569_1439.ECDH1ME8569_0597,iECD_1391.ECD_00597,iECED1_1282.ECED1_0624,iECH74115_1262.ECH74115_0716,iECIAI1_1343.ECIAI1_0611,iECIAI39_1322.ECIAI39_0603,iECNA114_1301.ECNA114_0567,iECO103_1326.ECO103_0635,iECO111_1330.ECO111_0658,iECO26_1355.ECO26_0702,iECOK1_1307.ECOK1_0638,iECP_1309.ECP_0658,iECS88_1305.ECS88_0669,iECSE_1348.ECSE_0695,iECSF_1327.ECSF_0567,iECSP_1301.ECSP_0681,iECUMN_1333.ECUMN_0720,iECW_1372.ECW_m0682,iECs_1301.ECs0666,iEKO11_1354.EKO11_3238,iETEC_1333.ETEC_0656,iEcDH1_1363.EcDH1_2998,iEcE24377_1341.EcE24377A_0652,iEcHS_1320.EcHS_A0679,iEcSMS35_1347.EcSMS35_0648,iEcolC_1368.EcolC_3017,iG2583_1286.G2583_0791,iJO1366.b0628,iLF82_1304.LF82_1199,iNRG857_1313.NRG857_02855,iSBO_1134.SBO_0492,iSDY_1059.SDY_0550,iSF_1195.SF0653,iSFxv_1172.SFxv_0720,iSSON_1240.SSON_0582,iS_1188.S0675,iSbBS512_1146.SbBS512_E0542,iUMN146_1321.UM146_14375,iUMNK88_1353.UMNK88_663,iUTI89_1310.UTI89_C0631,iWFL_1372.ECW_m0682,iY75_1357.Y75_RS03275,ic_1306.c0718 LIAS_N,Radical_SAM k59_1770678_2 1001585.MDS_1993 8.98e-35 135.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1YEI8@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria T Putative diguanylate phosphodiesterase - - - - - - - - - - - - EAL,GGDEF,PAS,PAS_3,PAS_4,PAS_9 k59_1375842_1 359.CN09_08450 1e-42 155.0 COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,2TQQJ@28211|Alphaproteobacteria,4B8N5@82115|Rhizobiaceae 28211|Alphaproteobacteria E Part of the ABC transporter complex UgpABCE involved in sn-glycerol-3-phosphate import. Responsible for energy coupling to the transport system ugpC - 3.6.3.20 ko:K05816 ko02010,map02010 M00198 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.1.3 - - ABC_tran,TOBE_2 k59_1658416_1 519989.ECTPHS_04568 1.1e-10 60.5 COG0394@1|root,COG0394@2|Bacteria,1RH90@1224|Proteobacteria,1S5X6@1236|Gammaproteobacteria,1WY50@135613|Chromatiales 135613|Chromatiales T low molecular weight - - 3.1.3.48 ko:K01104 - - - - ko00000,ko01000 - - - LMWPc k59_1714043_1 479434.Sthe_0596 6.37e-76 247.0 COG0492@1|root,COG3437@1|root,COG0492@2|Bacteria,COG3437@2|Bacteria,2G5Z5@200795|Chloroflexi 200795|Chloroflexi C FAD-dependent pyridine nucleotide-disulphide oxidoreductase - - 1.8.1.9 ko:K00384 ko00450,map00450 - R02016,R03596,R09372 RC00013,RC02518,RC02873 ko00000,ko00001,ko01000 - - - Pyr_redox_2,Response_reg k59_189295_1 1298593.TOL_2309 2.35e-10 60.8 COG0679@1|root,COG0679@2|Bacteria,1P2SH@1224|Proteobacteria,1RQGC@1236|Gammaproteobacteria,1XRNP@135619|Oceanospirillales 135619|Oceanospirillales S Membrane transport protein - - - ko:K07088 - - - - ko00000 - - - Mem_trans k59_1205780_1 1379270.AUXF01000002_gene1559 2.79e-127 373.0 COG3832@1|root,COG3832@2|Bacteria,1ZUBY@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Activator of Hsp90 ATPase homolog 1-like protein - - - - - - - - - - - - AHSA1 k59_640869_1 1114964.L485_16570 2.18e-91 290.0 COG1629@1|root,COG4771@2|Bacteria,1MVFB@1224|Proteobacteria,2U0N7@28211|Alphaproteobacteria,2KEFU@204457|Sphingomonadales 204457|Sphingomonadales P TonB-dependent receptor plug - - - - - - - - - - - - Plug,TonB_dep_Rec k59_189302_1 2340.JV46_14410 2e-58 207.0 COG1196@1|root,COG1196@2|Bacteria,1MUAQ@1224|Proteobacteria,1RNA6@1236|Gammaproteobacteria,1J4IV@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria D Required for chromosome condensation and partitioning smc - - ko:K03529 - - - - ko00000,ko03036 - - - SMC_N,SMC_hinge k59_76959_1 926569.ANT_03840 5.61e-24 97.8 COG0359@1|root,COG0359@2|Bacteria,2G6V2@200795|Chloroflexi 200795|Chloroflexi J Binds to the 23S rRNA rplI GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02939 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L9_C,Ribosomal_L9_N k59_19597_1 756272.Plabr_1651 4.57e-08 60.1 COG1073@1|root,COG1073@2|Bacteria,2IWT8@203682|Planctomycetes 203682|Planctomycetes S alpha beta - - - - - - - - - - - - - k59_1714060_1 436308.Nmar_0433 1.54e-93 279.0 COG2123@1|root,arCOG01574@2157|Archaea,41SFZ@651137|Thaumarchaeota 651137|Thaumarchaeota J Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Contributes to the structuring of the Rrp41 active site rrp42 - - ko:K12589 ko03018,map03018 M00390,M00391 - - ko00000,ko00001,ko00002,ko03019 - - - RNase_PH,RNase_PH_C k59_359056_1 1280952.HJA_13060 5.97e-46 159.0 COG3616@1|root,COG3616@2|Bacteria,1MXV3@1224|Proteobacteria,2TTPK@28211|Alphaproteobacteria,43ZE0@69657|Hyphomonadaceae 28211|Alphaproteobacteria E amino acid aldolase or racemase - - - - - - - - - - - - Ala_racemase_N k59_359056_2 1280952.HJA_05872 1.32e-34 128.0 COG1309@1|root,COG1309@2|Bacteria 2|Bacteria K transcriptional regulator - - - - - - - - - - - - TetR_N k59_584163_1 448385.sce0567 3.2e-21 98.2 COG3973@1|root,COG3973@2|Bacteria,1P638@1224|Proteobacteria,42MXR@68525|delta/epsilon subdivisions,2WK1Z@28221|Deltaproteobacteria,2Z32G@29|Myxococcales 28221|Deltaproteobacteria L DNA helicase - - 3.6.4.12 ko:K03657 ko03420,ko03430,map03420,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - AAA_19,UvrD_C_2 k59_810877_1 247639.MGP2080_07614 3.25e-60 194.0 COG2041@1|root,COG2041@2|Bacteria,1MUW0@1224|Proteobacteria,1RQ2J@1236|Gammaproteobacteria,1J5HC@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide msrP GO:0000302,GO:0001101,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009987,GO:0010035,GO:0016491,GO:0016667,GO:0016672,GO:0016675,GO:0019538,GO:0030091,GO:0030288,GO:0030313,GO:0031975,GO:0042221,GO:0042597,GO:0043170,GO:0043546,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0048037,GO:0050662,GO:0050896,GO:0055114,GO:0071704,GO:0097159,GO:1901363,GO:1901530,GO:1901564,GO:1901700 - ko:K07147 - - - - ko00000,ko01000 - - - Oxidored_molyb k59_810877_2 2340.JV46_27190 5.27e-06 49.3 COG2717@1|root,COG2717@2|Bacteria,1RDUP@1224|Proteobacteria,1RS9K@1236|Gammaproteobacteria,1J6EB@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain msrQ GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010181,GO:0016020,GO:0016021,GO:0016491,GO:0016679,GO:0019538,GO:0020037,GO:0030091,GO:0031224,GO:0031226,GO:0032553,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0046906,GO:0048037,GO:0050662,GO:0055114,GO:0071704,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901564 - ko:K17247 - - - - ko00000 - - - Ferric_reduct k59_1431429_2 1068980.ARVW01000001_gene6930 1.26e-05 50.8 COG1309@1|root,COG1309@2|Bacteria,2IBTG@201174|Actinobacteria 201174|Actinobacteria K Bacterial regulatory proteins, tetR family - - - - - - - - - - - - TetR_N k59_1601284_1 436308.Nmar_1086 1.49e-121 357.0 COG0505@1|root,arCOG00064@2157|Archaea,41SF0@651137|Thaumarchaeota 651137|Thaumarchaeota E carbamoyl-phosphate synthase, small subunit carA - 6.3.5.5 ko:K01956 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - - CPSase_sm_chain,GATase k59_1149025_1 477184.KYC_13522 1.64e-20 97.8 COG1251@1|root,COG1251@2|Bacteria,1MW58@1224|Proteobacteria,2VIEA@28216|Betaproteobacteria,3T39I@506|Alcaligenaceae 28216|Betaproteobacteria C Nitrite reductase nirB - 1.18.1.1,1.7.1.15 ko:K00362,ko:K05297 ko00071,ko00910,ko01120,map00071,map00910,map01120 M00530 R00787,R02000 RC00176 ko00000,ko00001,ko00002,ko01000 - - - Fer2_BFD,NIR_SIR,NIR_SIR_ferr,Pyr_redox_2 k59_753684_1 1122137.AQXF01000003_gene1913 1.42e-104 305.0 COG4122@1|root,COG4122@2|Bacteria 2|Bacteria E O-methyltransferase activity pafA2 - 3.5.1.119 ko:K20814 - - - - ko00000,ko01000,ko03051 - - - Methyltransf_21,Pup_ligase k59_1658440_1 1229909.NSED_08020 9.8e-31 119.0 COG0015@1|root,arCOG01747@2157|Archaea,41SD1@651137|Thaumarchaeota 651137|Thaumarchaeota F adenylosuccinate lyase - - 4.3.2.2 ko:K01756 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048,M00049 R01083,R04559 RC00379,RC00444,RC00445 ko00000,ko00001,ko00002,ko01000 - - - ADSL_C,Lyase_1 k59_1771487_1 1266925.JHVX01000010_gene1321 2.99e-30 119.0 COG1123@1|root,COG4172@2|Bacteria,1MU09@1224|Proteobacteria,2VH5T@28216|Betaproteobacteria,372B6@32003|Nitrosomonadales 28216|Betaproteobacteria P Belongs to the ABC transporter superfamily dppF - - ko:K02031,ko:K02032 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - ABC_tran,oligo_HPY k59_303828_1 1122137.AQXF01000007_gene3525 1.2e-198 563.0 COG1053@1|root,COG1053@2|Bacteria,1MU5M@1224|Proteobacteria,2TQJA@28211|Alphaproteobacteria 28211|Alphaproteobacteria C Belongs to the FAD-dependent oxidoreductase 2 family. FRD SDH subfamily sdhA - 1.3.5.1,1.3.5.4 ko:K00239 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134 M00009,M00011,M00149,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,Succ_DH_flav_C k59_1207102_1 472759.Nhal_2013 2.59e-12 65.1 COG0776@1|root,COG0776@2|Bacteria,1RFWH@1224|Proteobacteria,1SBVN@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Belongs to the bacterial histone-like protein family hup - - - - - - - - - - - Bac_DNA_binding k59_1048384_1 663610.JQKO01000008_gene76 1.33e-05 48.1 COG0845@1|root,COG0845@2|Bacteria,1MUFW@1224|Proteobacteria,2U2CU@28211|Alphaproteobacteria,3NASE@45404|Beijerinckiaceae 28211|Alphaproteobacteria M HlyD family secretion protein - - - ko:K03585 ko01501,ko01503,map01501,map01503 M00646,M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000,ko03036 2.A.6.2,8.A.1.6 - - HlyD_D23 k59_1048384_2 314285.KT71_03780 2.04e-45 164.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1J4V8@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K18138 ko01501,ko01503,map01501,map01503 M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000 2.A.6.2 - - ACR_tran k59_1048387_1 1381751.JAJB01000028_gene1325 0.000359 46.2 COG3275@1|root,COG3275@2|Bacteria,2HEXS@201174|Actinobacteria,4F8YK@85019|Brevibacteriaceae 201174|Actinobacteria T phosphorelay sensor kinase activity - - - ko:K16923 - M00582 - - ko00000,ko00002,ko02000 3.A.1.28 - - - k59_256243_1 1122137.AQXF01000006_gene877 2.28e-70 227.0 COG2939@1|root,COG2939@2|Bacteria,1MW05@1224|Proteobacteria,2TS7R@28211|Alphaproteobacteria 28211|Alphaproteobacteria E PFAM peptidase S10 serine carboxypeptidase - - - - - - - - - - - - Peptidase_S10 k59_256243_2 1122137.AQXF01000006_gene876 4.93e-18 80.9 COG0061@1|root,COG0061@2|Bacteria,1MUBC@1224|Proteobacteria,2TSKN@28211|Alphaproteobacteria 28211|Alphaproteobacteria H Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP nadK - 2.7.1.23 ko:K00858 ko00760,ko01100,map00760,map01100 - R00104 RC00002,RC00078 ko00000,ko00001,ko01000 - - - NAD_kinase k59_761752_1 641526.ADIWIN_0743 3.67e-11 65.5 2DNBA@1|root,32WJE@2|Bacteria,4NUM3@976|Bacteroidetes,1I4CD@117743|Flavobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_761752_2 216432.CA2559_08066 6.81e-20 85.9 COG0177@1|root,COG0177@2|Bacteria,4NE7K@976|Bacteroidetes,1HWQK@117743|Flavobacteriia 976|Bacteroidetes L TIGRFAM TIGR02757 family protein - - - - - - - - - - - - DUF2400 k59_1270472_2 314232.SKA53_13736 9.81e-10 57.0 COG1977@1|root,COG1977@2|Bacteria,1N0IE@1224|Proteobacteria,2UF4F@28211|Alphaproteobacteria,2P92C@245186|Loktanella 28211|Alphaproteobacteria H Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin moaD - - ko:K03636 ko04122,map04122 - - - ko00000,ko00001 - - - ThiS k59_1327257_1 1500897.JQNA01000002_gene4921 7.41e-20 88.6 COG0019@1|root,COG0019@2|Bacteria,1MUA6@1224|Proteobacteria,2VI3M@28216|Betaproteobacteria,1K0I1@119060|Burkholderiaceae 28216|Betaproteobacteria E Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine lysA - 4.1.1.20 ko:K01586 ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R00451 RC00299 ko00000,ko00001,ko00002,ko01000 - - - Orn_Arg_deC_N,Orn_DAP_Arg_deC k59_879275_1 580332.Slit_1703 3.31e-34 124.0 COG3439@1|root,COG3439@2|Bacteria,1RHPD@1224|Proteobacteria,2VV5X@28216|Betaproteobacteria 28216|Betaproteobacteria S Domain of unknown function DUF302 - - - - - - - - - - - - DUF302 k59_1612525_1 1207055.C100_19055 4.14e-221 629.0 COG0376@1|root,COG0376@2|Bacteria,1MUBF@1224|Proteobacteria,2TQJ7@28211|Alphaproteobacteria,2K0B7@204457|Sphingomonadales 204457|Sphingomonadales P Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity katG - 1.11.1.21 ko:K03782 ko00360,ko00380,ko00940,ko00983,ko01100,ko01110,map00360,map00380,map00940,map00983,map01100,map01110 - R00602,R00698,R02596,R02670,R03919,R04007,R07443,R11906 RC00034,RC00213,RC00767,RC02141 ko00000,ko00001,ko01000 - - - peroxidase k59_1387469_1 1536774.H70357_22995 2.89e-21 96.3 COG1595@1|root,COG1595@2|Bacteria,1UZM5@1239|Firmicutes,4HEK0@91061|Bacilli,26SC7@186822|Paenibacillaceae 91061|Bacilli K Belongs to the sigma-70 factor family. ECF subfamily rpoE3 - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 k59_1500641_2 1121382.JQKG01000020_gene1221 9.1e-94 293.0 COG2070@1|root,COG2070@2|Bacteria,1WMCT@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus S Nitronate monooxygenase - - - - - - - - - - - - NMO k59_708844_1 1229909.NSED_00710 5.11e-119 347.0 COG0040@1|root,arCOG02208@2157|Archaea,41SCJ@651137|Thaumarchaeota 651137|Thaumarchaeota E ATP phosphoribosyltransferase - - 2.4.2.17 ko:K00765 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R01071 RC02819,RC03200 ko00000,ko00001,ko00002,ko01000 - - - HisG,HisG_C k59_708844_2 1229909.NSED_00705 3.99e-19 85.9 COG1257@1|root,arCOG04260@2157|Archaea,41SAU@651137|Thaumarchaeota 651137|Thaumarchaeota I Belongs to the HMG-CoA reductase family - - 1.1.1.88 ko:K00054 ko00900,ko01110,ko01130,map00900,map01110,map01130 - R02081 RC00004,RC00644 ko00000,ko00001,ko01000 - - - HMG-CoA_red k59_708847_1 591167.Sfla_4731 1.43e-09 62.8 COG0769@1|root,COG0769@2|Bacteria,2GIS2@201174|Actinobacteria 201174|Actinobacteria M acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan murE GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008765,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016874,GO:0016879,GO:0016881,GO:0030203,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 6.3.2.13 ko:K01928 ko00300,ko00550,map00300,map00550 - R02788 RC00064,RC00090 ko00000,ko00001,ko01000,ko01011 - - iNJ661.Rv2158c Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_1327271_1 555793.WSK_0501 4.87e-29 111.0 COG0797@1|root,COG0797@2|Bacteria,1MZ8S@1224|Proteobacteria,2UBTC@28211|Alphaproteobacteria,2K5XU@204457|Sphingomonadales 204457|Sphingomonadales M Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides rlpA - - ko:K03642 - - - - ko00000 - - - DPBB_1 k59_1557590_1 714083.JH370377_gene505 1.5e-09 62.4 COG1597@1|root,COG1597@2|Bacteria,2GJ3K@201174|Actinobacteria,4FKAS@85023|Microbacteriaceae 201174|Actinobacteria I Diacylglycerol kinase catalytic domain - - - - - - - - - - - - DAGK_cat k59_708852_1 1085623.GNIT_3458 5.9e-82 258.0 COG0138@1|root,COG0138@2|Bacteria,1MUDQ@1224|Proteobacteria,1RMWS@1236|Gammaproteobacteria,4646Q@72275|Alteromonadaceae 1236|Gammaproteobacteria F COG0138 AICAR transformylase IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful) purH GO:0003674,GO:0003824,GO:0004643,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016741,GO:0016742,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.2.3,3.5.4.10 ko:K00602 ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523 M00048 R01127,R04560 RC00026,RC00263,RC00456 ko00000,ko00001,ko00002,ko01000,ko04147 - - iEcHS_1320.EcHS_A4240,iPC815.YPO3728 AICARFT_IMPCHas,MGS k59_423915_1 722419.PH505_be00340 5.19e-84 262.0 COG0189@1|root,COG0189@2|Bacteria,1MX5X@1224|Proteobacteria,1RNXP@1236|Gammaproteobacteria,2Q1MC@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria HJ Belongs to the D-alanine--D-alanine ligase family - - - - - - - - - - - - Dala_Dala_lig_C,RLAN,RimK k59_479488_1 580332.Slit_0818 4.13e-46 157.0 COG5660@1|root,2Z7TM@2|Bacteria,1PMCV@1224|Proteobacteria,2VWPY@28216|Betaproteobacteria 28216|Betaproteobacteria S TRAP transporter T-component - - - - - - - - - - - - TAtT k59_1048453_1 247634.GPB2148_2033 3.21e-79 247.0 COG2230@1|root,COG2230@2|Bacteria,1MX3U@1224|Proteobacteria,1RNID@1236|Gammaproteobacteria 1236|Gammaproteobacteria M synthase cfa - 2.1.1.79 ko:K00574 - - - - ko00000,ko01000 - - iJN746.PP_2734 CMAS k59_931628_2 595537.Varpa_5610 2.81e-71 221.0 COG0412@1|root,COG0412@2|Bacteria,1MW88@1224|Proteobacteria,2VQD1@28216|Betaproteobacteria,4ACGY@80864|Comamonadaceae 28216|Betaproteobacteria Q dienelactone hydrolase - - 3.1.1.45 ko:K01061 ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130 - R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222 RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686 ko00000,ko00001,ko01000 - - - DLH k59_31449_1 1122223.KB890696_gene244 2.72e-33 127.0 COG0324@1|root,COG0324@2|Bacteria,1WIBB@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus J Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) miaA GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016765,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0052381,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.5.1.75 ko:K00791 ko00908,ko01100,ko01110,map00908,map01100,map01110 - R01122 RC02820 ko00000,ko00001,ko01000,ko01006,ko03016 - - - IPPT k59_987407_1 1454004.AW11_03212 1.64e-104 317.0 COG3119@1|root,COG3119@2|Bacteria,1MV92@1224|Proteobacteria,2VIFW@28216|Betaproteobacteria,1KR2K@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria P C-terminal region of aryl-sulfatase - - - - - - - - - - - - Sulfatase,Sulfatase_C k59_314259_1 1178825.ALIH01000013_gene542 4.53e-31 120.0 COG3292@1|root,COG3292@2|Bacteria,4NDWE@976|Bacteroidetes,1HY9S@117743|Flavobacteriia 976|Bacteroidetes T periplasmic ligand-binding sensor domain - - - - - - - - - - - - Reg_prop k59_314259_2 391603.FBALC1_01212 5.59e-39 137.0 COG1381@1|root,COG1381@2|Bacteria,4NIBQ@976|Bacteroidetes,1I1E3@117743|Flavobacteriia 976|Bacteroidetes L Involved in DNA repair and RecF pathway recombination recO - - ko:K03584 ko03440,map03440 - - - ko00000,ko00001,ko03400 - - - RecO_C,RecO_N k59_1101564_1 1096930.L284_04625 3.41e-136 412.0 COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,2TRJF@28211|Alphaproteobacteria,2K1KW@204457|Sphingomonadales 204457|Sphingomonadales L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity polA - 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1 k59_198630_2 1121033.AUCF01000028_gene350 1.11e-11 67.4 COG1595@1|root,COG1595@2|Bacteria,1MZMC@1224|Proteobacteria,2TUUZ@28211|Alphaproteobacteria,2JTDN@204441|Rhodospirillales 204441|Rhodospirillales K Belongs to the sigma-70 factor family. ECF subfamily - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 k59_987408_1 1122137.AQXF01000003_gene2412 1.44e-10 59.3 COG0219@1|root,COG0219@2|Bacteria,1RCY4@1224|Proteobacteria,2U78W@28211|Alphaproteobacteria 28211|Alphaproteobacteria J Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide trmL - 2.1.1.207 ko:K03216 - - - - ko00000,ko01000,ko03016 - - - SpoU_methylase k59_987408_2 1122137.AQXF01000003_gene2411 1.67e-137 394.0 COG0408@1|root,COG0408@2|Bacteria,1MWMF@1224|Proteobacteria,2TQNC@28211|Alphaproteobacteria 28211|Alphaproteobacteria H Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX hemF GO:0003674,GO:0005488,GO:0005515,GO:0042802,GO:0042803,GO:0046983 1.3.3.3 ko:K00228 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R03220 RC00884 ko00000,ko00001,ko00002,ko01000 - - - Coprogen_oxidas k59_371022_1 1210884.HG799465_gene12259 1.59e-57 204.0 COG4191@1|root,COG4191@2|Bacteria,2IWUM@203682|Planctomycetes 203682|Planctomycetes T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - GAF,GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg k59_1387530_1 998674.ATTE01000001_gene2426 7.62e-163 466.0 COG0012@1|root,COG0012@2|Bacteria,1MVM4@1224|Proteobacteria,1RMBI@1236|Gammaproteobacteria,45ZRA@72273|Thiotrichales 72273|Thiotrichales J ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner ychF - - ko:K06942 - - - - ko00000,ko03009 - - - MMR_HSR1,YchF-GTPase_C k59_1439960_1 745718.JADT01000008_gene3088 5.66e-81 245.0 COG0461@1|root,COG0461@2|Bacteria,4NEF8@976|Bacteroidetes,1HXXU@117743|Flavobacteriia 976|Bacteroidetes F Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) pyrE - 2.4.2.10,4.1.1.23 ko:K00762,ko:K13421 ko00240,ko00983,ko01100,map00240,map00983,map01100 M00051 R00965,R01870,R08231 RC00063,RC00409,RC00611 ko00000,ko00001,ko00002,ko01000 - - - OMPdecase,Pribosyltran k59_479501_1 1415779.JOMH01000001_gene447 3.88e-17 82.0 COG0642@1|root,COG0642@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,1SKTW@1236|Gammaproteobacteria,1XD55@135614|Xanthomonadales 135614|Xanthomonadales T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA,Hpt,PAS_3,PAS_4,PAS_9,Response_reg k59_479501_2 756067.MicvaDRAFT_2827 1.32e-25 109.0 COG5001@1|root,COG5001@2|Bacteria,1G0SY@1117|Cyanobacteria,1H8WC@1150|Oscillatoriales 1117|Cyanobacteria T Response regulator receiver domain - - - - - - - - - - - - EAL,GGDEF,Response_reg k59_708888_2 930166.CD58_19660 1.59e-05 53.5 COG0616@1|root,COG0616@2|Bacteria,1MUXE@1224|Proteobacteria,1RNN9@1236|Gammaproteobacteria 1236|Gammaproteobacteria OU peptidase sohB GO:0005575,GO:0005623,GO:0005886,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0016020,GO:0019538,GO:0043170,GO:0044238,GO:0044464,GO:0071704,GO:0071944,GO:1901564 - ko:K04774 - - - - ko00000,ko01000,ko01002 - - - Peptidase_S49,Peptidase_S49_N k59_931644_1 1117647.M5M_05195 2.17e-88 290.0 COG0587@1|root,COG0587@2|Bacteria,1MUIF@1224|Proteobacteria,1RP0K@1236|Gammaproteobacteria,1J4NP@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L DNA polymerase III, alpha subunit dnaE GO:0003674,GO:0003824,GO:0003887,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032991,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0042575,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044776,GO:0046483,GO:0061695,GO:0071704,GO:0071897,GO:0090304,GO:0140097,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234 2.7.7.7 ko:K02337 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon k59_1500718_1 1121374.KB891585_gene1948 1.22e-64 214.0 COG1283@1|root,COG1283@2|Bacteria,1MUDE@1224|Proteobacteria,1RNMM@1236|Gammaproteobacteria 1236|Gammaproteobacteria P Na Pi-Cotransporter - - - ko:K03324 - - - - ko00000,ko02000 2.A.58.2 - - Na_Pi_cotrans k59_314285_2 93220.LV28_22660 2.05e-50 167.0 COG2716@1|root,COG2716@2|Bacteria,1MZJ6@1224|Proteobacteria,2VRVD@28216|Betaproteobacteria 28216|Betaproteobacteria E Glycine cleavage system regulatory protein gcvR - - - - - - - - - - - ACT,ACT_6 k59_256334_1 10224.XP_002738379.1 1.68e-53 185.0 COG4638@1|root,2QQJW@2759|Eukaryota,39XH1@33154|Opisthokonta,3BZMW@33208|Metazoa,3DEK0@33213|Bilateria 33208|Metazoa P Ring hydroxylating alpha subunit (catalytic domain) - - 1.14.15.7 ko:K00499 ko00260,map00260 - R07409 RC00087 ko00000,ko00001,ko01000 - - - Rieske,Ring_hydroxyl_A k59_1777829_1 1123277.KB893217_gene4444 3.82e-23 100.0 COG1058@1|root,COG1546@1|root,COG1058@2|Bacteria,COG1546@2|Bacteria,4NDVV@976|Bacteroidetes,47JN4@768503|Cytophagia 976|Bacteroidetes S CinA-like protein cinA - 3.5.1.42 ko:K03742,ko:K03743 ko00760,map00760 - R02322 RC00100 ko00000,ko00001,ko01000 - - - CinA,MoCF_biosynth k59_1777829_2 96561.Dole_1265 5.77e-24 97.1 COG1267@1|root,COG1267@2|Bacteria,1MZJA@1224|Proteobacteria,42U6G@68525|delta/epsilon subdivisions,2WQDR@28221|Deltaproteobacteria,2MKIR@213118|Desulfobacterales 28221|Deltaproteobacteria I Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG) pgpA - 3.1.3.27 ko:K01095 ko00564,ko01100,map00564,map01100 - R02029 RC00017 ko00000,ko00001,ko01000 - - iAF987.Gmet_0195 PgpA k59_820267_1 29581.BW37_03696 1.61e-75 250.0 COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2VI18@28216|Betaproteobacteria,473H2@75682|Oxalobacteraceae 28216|Betaproteobacteria C Aldehyde dehydrogenase family - - 1.2.1.3 ko:K00128 ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130 M00135 R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146 RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_257582_1 1124780.ANNU01000062_gene555 4.42e-40 147.0 COG2204@1|root,COG2204@2|Bacteria,4NE89@976|Bacteroidetes,47JF9@768503|Cytophagia 976|Bacteroidetes T two component, sigma54 specific, transcriptional regulator, Fis family - - - - - - - - - - - - HTH_8,Response_reg,Sigma54_activat k59_1160652_1 321846.PS417_27980 7.05e-90 287.0 COG0542@1|root,COG0542@2|Bacteria,1MVBH@1224|Proteobacteria,1RMZH@1236|Gammaproteobacteria 1236|Gammaproteobacteria O Belongs to the ClpA ClpB family clpV - - ko:K11907 ko02025,ko03070,map02025,map03070 M00334 - - ko00000,ko00001,ko00002,ko02044 3.A.23.1 - - AAA,AAA_2,ClpB_D2-small,Clp_N k59_1440944_1 436308.Nmar_1573 1e-132 389.0 COG0519@1|root,arCOG00085@2157|Archaea,41SDI@651137|Thaumarchaeota 651137|Thaumarchaeota F Catalyzes the synthesis of GMP from XMP guaA - 6.3.5.2 ko:K01951 ko00230,ko00983,ko01100,map00230,map00983,map01100 M00050 R01230,R01231,R08244 RC00010,RC00204 ko00000,ko00001,ko00002,ko01000,ko01002 - - - GATase,GMP_synt_C,NAD_synthase k59_372335_1 1469245.JFBG01000007_gene640 5.93e-18 83.6 COG4631@1|root,COG4631@2|Bacteria,1NQSR@1224|Proteobacteria,1T1HI@1236|Gammaproteobacteria 1236|Gammaproteobacteria F Xanthine dehydrogenase xdhB - 1.17.1.4 ko:K13482 ko00230,ko01100,ko01120,map00230,map01100,map01120 M00546 R01768,R02103 RC00143 ko00000,ko00001,ko00002,ko01000 - - - Ald_Xan_dh_C,Ald_Xan_dh_C2 k59_372335_2 266809.PM03_01310 4.47e-16 79.7 COG1975@1|root,COG1975@2|Bacteria,1R3RT@1224|Proteobacteria,2TUI0@28211|Alphaproteobacteria 28211|Alphaproteobacteria O COG1975 Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family xdhC - - ko:K07402 - - - - ko00000 - - - XdhC_C,XdhC_CoxI k59_1778675_1 935567.JAES01000001_gene2182 6.55e-34 133.0 COG1508@1|root,COG1508@2|Bacteria,1MW4V@1224|Proteobacteria,1RMY0@1236|Gammaproteobacteria,1X3TH@135614|Xanthomonadales 135614|Xanthomonadales K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released rpoN - - ko:K03092 ko02020,ko05111,map02020,map05111 - - - ko00000,ko00001,ko03021 - - - Sigma54_AID,Sigma54_CBD,Sigma54_DBD k59_143904_1 926550.CLDAP_30470 5.76e-77 254.0 COG0243@1|root,COG0243@2|Bacteria,2G5ZB@200795|Chloroflexi 200795|Chloroflexi C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - - - - - - - - - - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding k59_1328221_1 1550073.JROH01000074_gene2862 1.74e-11 62.8 2AEG6@1|root,314B9@2|Bacteria,1NMR1@1224|Proteobacteria,2UU1S@28211|Alphaproteobacteria,2K71V@204457|Sphingomonadales 204457|Sphingomonadales S Gluconate 2-dehydrogenase subunit 3 - - - - - - - - - - - - Gluconate_2-dh3 k59_1328221_2 1502850.FG91_01901 2.99e-69 224.0 COG2303@1|root,COG2303@2|Bacteria,1MU3F@1224|Proteobacteria,2TT3C@28211|Alphaproteobacteria,2K0QC@204457|Sphingomonadales 204457|Sphingomonadales E Oxidoreductase - - 1.1.5.9 ko:K19813 ko00030,ko01100,ko01110,ko01130,map00030,map01100,map01110,map01130 - R00305 RC00066 ko00000,ko00001,ko01000 - - - FAD_binding_2,GMC_oxred_C,GMC_oxred_N,NAD_binding_8 k59_1049942_1 765911.Thivi_3000 4.75e-39 149.0 COG0642@1|root,COG0784@1|root,COG2202@1|root,COG0784@2|Bacteria,COG2202@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,1RQ3H@1236|Gammaproteobacteria,1WW3T@135613|Chromatiales 135613|Chromatiales T response regulator receiver - - - - - - - - - - - - HATPase_c,HisKA,PAS_3,PAS_4,PAS_9,Response_reg k59_1328228_1 290397.Adeh_0342 6.46e-18 84.7 COG1575@1|root,COG1575@2|Bacteria 2|Bacteria H Belongs to the MenA family. Type 1 subfamily menA GO:0000287,GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0006766,GO:0006775,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009233,GO:0009234,GO:0009987,GO:0016020,GO:0016740,GO:0016765,GO:0032194,GO:0042180,GO:0042181,GO:0042362,GO:0042371,GO:0042373,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046428,GO:0046872,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:1901576,GO:1901661,GO:1901663 2.5.1.74 ko:K02548 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116 R05617,R06858,R10757 RC02935,RC02936,RC03264 ko00000,ko00001,ko00002,ko01000,ko01006 - - iECH74115_1262.ECH74115_5387,iG2583_1286.G2583_4737 UbiA k59_1328228_2 314285.KT71_03995 5.63e-23 94.4 COG3806@1|root,COG3806@2|Bacteria,1RI6T@1224|Proteobacteria,1S341@1236|Gammaproteobacteria,1J98V@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T ChrR Cupin-like domain chrR - - ko:K07167 - - - - ko00000 - - - Cupin_7 k59_1049947_1 1163617.SCD_n03013 4.3e-11 63.2 COG1651@1|root,COG1651@2|Bacteria,1RGWH@1224|Proteobacteria,2VSFV@28216|Betaproteobacteria 28216|Betaproteobacteria O Thiol disulfide interchange protein dsbA - - ko:K03673 ko01503,map01503 M00728 - - ko00000,ko00001,ko00002,ko03110 - - - DSBA,Thioredoxin_4 k59_1049947_2 1121918.ARWE01000001_gene1081 7.71e-19 90.9 COG3034@1|root,COG3034@2|Bacteria,1N2B6@1224|Proteobacteria,42QS4@68525|delta/epsilon subdivisions,2WPZF@28221|Deltaproteobacteria 28221|Deltaproteobacteria S L,D-transpeptidase catalytic domain - - - - - - - - - - - - YkuD k59_480444_1 1415778.JQMM01000001_gene82 5.68e-72 229.0 COG3705@1|root,COG3705@2|Bacteria,1MWIG@1224|Proteobacteria,1RPRQ@1236|Gammaproteobacteria,1J4S0@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine hisZ - - ko:K02502 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R01071 RC02819,RC03200 ko00000,ko00001,ko00002 - - - tRNA-synt_His k59_597093_1 1245469.S58_11920 4.68e-78 239.0 COG1028@1|root,COG1028@2|Bacteria,1MXQR@1224|Proteobacteria,2TW65@28211|Alphaproteobacteria,3JTUA@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria IQ Enoyl-(Acyl carrier protein) reductase MA20_18140 - 1.1.1.100 ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 k59_762758_1 67281.JNZZ01000001_gene2359 8.75e-38 132.0 COG0346@1|root,COG0346@2|Bacteria,2IFMD@201174|Actinobacteria,41AU2@629295|Streptomyces griseus group 201174|Actinobacteria E lactoylglutathione lyase activity - - - - - - - - - - - - - k59_762758_2 1121878.AUGL01000009_gene3415 1.08e-25 107.0 COG0463@1|root,COG0463@2|Bacteria,1MWE5@1224|Proteobacteria,1RPCE@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Catalyzes the transfer of 4-deoxy-4-formamido-L- arabinose from UDP to undecaprenyl phosphate. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides gtrB GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K20534 - - - - ko00000,ko01000,ko01005,ko02000 4.D.2.1.9 GT2 - Glycos_transf_2 k59_1726161_1 1111730.ATTM01000004_gene2133 5.48e-28 117.0 COG1345@1|root,COG1361@1|root,COG2373@1|root,COG1345@2|Bacteria,COG1361@2|Bacteria,COG2373@2|Bacteria,4NFVP@976|Bacteroidetes,1HY1K@117743|Flavobacteriia,2NSFX@237|Flavobacterium 976|Bacteroidetes N PFAM SMP-30 Gluconolaconase - - - - - - - - - - - - CUB,LTD,fn3 k59_1328241_1 722419.PH505_bv00240 3.03e-09 60.5 COG1639@1|root,COG1639@2|Bacteria,1N7EN@1224|Proteobacteria,1RT8G@1236|Gammaproteobacteria,2Q16K@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria T Signal transduction protein - - 6.3.1.2 ko:K01915 ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 - R00253 RC00010,RC02798 ko00000,ko00001,ko01000,ko04147 - - - HDOD k59_1328241_2 880071.Fleli_1829 2.82e-26 109.0 COG1960@1|root,COG1960@2|Bacteria,4NEHA@976|Bacteroidetes,47JZA@768503|Cytophagia 976|Bacteroidetes I acyl-CoA dehydrogenase acdA - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_1388968_1 436308.Nmar_0102 9.47e-113 328.0 COG0090@1|root,arCOG04067@2157|Archaea,41SCT@651137|Thaumarchaeota 651137|Thaumarchaeota J One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity rpl2 - - ko:K02886 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L2,Ribosomal_L2_C k59_315713_2 1279017.AQYJ01000028_gene2499 8.48e-49 159.0 COG0735@1|root,COG0735@2|Bacteria,1RDWJ@1224|Proteobacteria,1S4H7@1236|Gammaproteobacteria,4674B@72275|Alteromonadaceae 1236|Gammaproteobacteria K Belongs to the Fur family fur - - ko:K03711 - - - - ko00000,ko03000 - - - FUR k59_1569043_2 1380391.JIAS01000014_gene2120 1.41e-49 171.0 COG0285@1|root,COG0285@2|Bacteria,1MVCH@1224|Proteobacteria,2TR64@28211|Alphaproteobacteria,2JPGC@204441|Rhodospirillales 204441|Rhodospirillales H Belongs to the folylpolyglutamate synthase family folC - 6.3.2.12,6.3.2.17 ko:K11754 ko00790,ko01100,map00790,map01100 M00126,M00841 R00942,R02237,R04241 RC00064,RC00090,RC00162 ko00000,ko00001,ko00002,ko01000 - - - Mur_ligase_M k59_1336415_1 1454202.PPBDW_140238___1 2.92e-08 56.2 COG1076@1|root,COG1076@2|Bacteria,1N270@1224|Proteobacteria,1RP0P@1236|Gammaproteobacteria,1XSR9@135623|Vibrionales 135623|Vibrionales O Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host djlA - - ko:K05801 - - - - ko00000,ko03110 - - - DnaJ,TerB k59_1336415_2 857087.Metme_0716 6.56e-77 238.0 COG0152@1|root,COG0152@2|Bacteria,1MUR9@1224|Proteobacteria,1RNNY@1236|Gammaproteobacteria,1XDSQ@135618|Methylococcales 135618|Methylococcales F SAICAR synthetase purC - 6.3.2.6 ko:K01923 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04591 RC00064,RC00162 ko00000,ko00001,ko00002,ko01000 - - - SAICAR_synt k59_488791_1 1122137.AQXF01000002_gene432 4.23e-83 254.0 COG0583@1|root,COG0583@2|Bacteria,1R7RW@1224|Proteobacteria,2U8Q9@28211|Alphaproteobacteria 28211|Alphaproteobacteria K Transcriptional regulator - - - - - - - - - - - - HTH_1,LysR_substrate k59_97944_1 690585.JNNU01000004_gene4125 1.42e-138 417.0 COG0280@1|root,COG0281@1|root,COG0280@2|Bacteria,COG0281@2|Bacteria,1MU0A@1224|Proteobacteria,2TQJT@28211|Alphaproteobacteria,4B8Q2@82115|Rhizobiaceae 28211|Alphaproteobacteria C malic enzyme tme - 1.1.1.40 ko:K00029 ko00620,ko00710,ko01100,ko01120,ko01200,map00620,map00710,map01100,map01120,map01200 M00169,M00172 R00216 RC00105 ko00000,ko00001,ko00002,ko01000 - - - Malic_M,PTA_PTB,malic k59_97944_2 446468.Ndas_2370 7.33e-16 77.8 COG0786@1|root,COG0786@2|Bacteria,2I8VA@201174|Actinobacteria 201174|Actinobacteria E glutamate symporter gltT - - ko:K03312 - - - - ko00000,ko02000 2.A.27 - - Glt_symporter k59_771110_1 627192.SLG_27970 4.5e-152 440.0 COG3670@1|root,COG3670@2|Bacteria,1MY1X@1224|Proteobacteria,2TS7A@28211|Alphaproteobacteria 28211|Alphaproteobacteria Q dioxygenase MA20_08640 - - ko:K11159 - - - - ko00000 - - - RPE65 k59_1511434_1 1380387.JADM01000002_gene2137 8.12e-89 273.0 COG1252@1|root,COG1252@2|Bacteria,1MX96@1224|Proteobacteria,1RM9I@1236|Gammaproteobacteria,1XHG8@135619|Oceanospirillales 135619|Oceanospirillales C NADH dehydrogenase ndh - 1.6.99.3 ko:K03885 ko00190,map00190 - - - ko00000,ko00001,ko01000 - - - Pyr_redox_2 k59_996963_1 1501391.LG35_07705 4.34e-07 55.5 COG1216@1|root,COG1216@2|Bacteria,4NKAZ@976|Bacteroidetes,2FRDA@200643|Bacteroidia 976|Bacteroidetes S Glycosyltransferase like family 2 - - - - - - - - - - - - Glycos_transf_2 k59_209754_1 1197477.IA57_12710 1.05e-114 367.0 COG3209@1|root,COG3291@1|root,COG3209@2|Bacteria,COG3291@2|Bacteria,4NDZC@976|Bacteroidetes,1HY1V@117743|Flavobacteriia 976|Bacteroidetes DZ adhesin AidA-related sprB - - - - - - - - - - - CHU_C,DUF11,SprB k59_209756_1 312153.Pnuc_1096 2.13e-17 86.7 COG0457@1|root,COG0859@1|root,COG3118@1|root,COG0457@2|Bacteria,COG0859@2|Bacteria,COG3118@2|Bacteria,1PEV4@1224|Proteobacteria,2W92U@28216|Betaproteobacteria,1K1Y1@119060|Burkholderiaceae 28216|Betaproteobacteria M Glycosyltransferase family 9 (heptosyltransferase) - - - - - - - - - - - - Glyco_transf_9,TPR_1,TPR_10,TPR_16,TPR_2,TPR_8 k59_543919_1 1205680.CAKO01000002_gene2850 1.26e-83 258.0 COG1633@1|root,COG1633@2|Bacteria,1R02H@1224|Proteobacteria,2TYHQ@28211|Alphaproteobacteria 28211|Alphaproteobacteria S P-aminobenzoate N-oxygenase AurF - - - - - - - - - - - - AurF k59_42169_1 631362.Thi970DRAFT_02339 6.56e-66 214.0 COG3852@1|root,COG3852@2|Bacteria,1MVN6@1224|Proteobacteria,1RN15@1236|Gammaproteobacteria,1WWFQ@135613|Chromatiales 135613|Chromatiales T signal transduction histidine kinase - - 2.7.13.3 ko:K07708 ko02020,map02020 M00497 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA,PAS,PAS_4 k59_42169_2 998674.ATTE01000001_gene2597 2.71e-08 54.3 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,4607S@72273|Thiotrichales 72273|Thiotrichales T nitrogen regulation protein NR(I) - - - ko:K07712 ko02020,map02020 M00497 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_1676366_1 1439940.BAY1663_02120 2.97e-69 223.0 COG1560@1|root,COG1560@2|Bacteria,1MVNI@1224|Proteobacteria,1RMZ5@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Catalyzes the transfer of laurate from lauroyl-acyl carrier protein (ACP) to Kdo(2)-lipid IV(A) to form Kdo(2)- (lauroyl)-lipid IV(A) lpxL GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0006082,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0006950,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0008951,GO:0009058,GO:0009245,GO:0009247,GO:0009266,GO:0009311,GO:0009312,GO:0009409,GO:0009628,GO:0009987,GO:0016020,GO:0016051,GO:0016053,GO:0016740,GO:0016746,GO:0016747,GO:0019637,GO:0019752,GO:0036103,GO:0036104,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046467,GO:0046493,GO:0050896,GO:0071704,GO:0071944,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 2.3.1.241,2.3.1.242 ko:K02517,ko:K12974 ko00540,ko01100,map00540,map01100 M00060 R05146,R10906 RC00037,RC00039 ko00000,ko00001,ko00002,ko01000,ko01005 - - iEC042_1314.EC042_2597,iSF_1195.SF1061,iS_1188.S1138,iYL1228.KPN_01068 Lip_A_acyltrans k59_659233_1 1100720.ALKN01000035_gene975 4.53e-42 142.0 COG3193@1|root,COG3193@2|Bacteria,1N08N@1224|Proteobacteria,2VUSK@28216|Betaproteobacteria 28216|Betaproteobacteria S Haem-degrading - - - - - - - - - - - - Haem_degrading k59_152258_1 1122179.KB890458_gene692 7.27e-32 127.0 COG1395@1|root,COG1395@2|Bacteria,4PHD6@976|Bacteroidetes,1IVF2@117747|Sphingobacteriia 976|Bacteroidetes K Pfam:SusD - - - ko:K21572 - - - - ko00000,ko02000 8.A.46.1,8.A.46.3 - - SusD-like_3,SusD_RagB k59_1398631_1 266779.Meso_1501 5.73e-61 201.0 COG4977@1|root,COG4977@2|Bacteria,1MUDK@1224|Proteobacteria,2U1C5@28211|Alphaproteobacteria,43KVP@69277|Phyllobacteriaceae 28211|Alphaproteobacteria K PFAM helix-turn-helix, AraC type ThiJ PfpI - - - - - - - - - - - - DJ-1_PfpI,HTH_18 k59_1621817_1 1122137.AQXF01000003_gene1915 5.14e-66 216.0 COG0477@1|root,COG2814@2|Bacteria,1MU1I@1224|Proteobacteria,2TVXT@28211|Alphaproteobacteria 28211|Alphaproteobacteria EGP Major facilitator Superfamily emrB - - ko:K03446 - M00701 - - ko00000,ko00002,ko02000 2.A.1.3 - - MFS_1 k59_1621817_2 1122137.AQXF01000003_gene1916 4.18e-161 461.0 COG1566@1|root,COG1566@2|Bacteria,1MU7I@1224|Proteobacteria,2TS39@28211|Alphaproteobacteria 28211|Alphaproteobacteria V PFAM secretion protein HlyD family protein - - - ko:K03543 - M00701 - - ko00000,ko00002,ko02000 8.A.1.1 - - Biotin_lipoyl_2,HlyD_3,HlyD_D23 k59_381927_1 247490.KSU1_D0400 4.77e-53 183.0 COG2204@1|root,COG2204@2|Bacteria 247490.KSU1_D0400|- T phosphorelay signal transduction system - - - - - - - - - - - - - k59_381927_2 411479.BACUNI_03344 0.000228 43.1 COG0642@1|root,COG0745@1|root,COG0745@2|Bacteria,COG2205@2|Bacteria,4NDXU@976|Bacteroidetes,2FM2N@200643|Bacteroidia,4ANEF@815|Bacteroidaceae 976|Bacteroidetes T adenylate cyclase carring two-component hybrid sensor and regulator domains - - - - - - - - - - - - HATPase_c,HTH_18,HisKA,Reg_prop,Response_reg,Y_Y_Y k59_1279868_2 1379270.AUXF01000001_gene2202 6.84e-13 70.9 COG2453@1|root,COG2453@2|Bacteria 2|Bacteria T phosphatase - - - - - - - - - - - - CDKN3,DSPc,Y_phosphatase3 k59_1279868_4 1173025.GEI7407_3449 1.44e-126 369.0 COG0627@1|root,COG0627@2|Bacteria,1G1D6@1117|Cyanobacteria,1H7I8@1150|Oscillatoriales 1117|Cyanobacteria S Serine hydrolase involved in the detoxification of formaldehyde - - 3.1.2.12 ko:K01070 ko00680,ko01120,ko01200,map00680,map01120,map01200 - R00527 RC00167,RC00320 ko00000,ko00001,ko01000 - CE1 - Esterase k59_1279868_5 1313304.CALK_2308 1.68e-30 118.0 COG0205@1|root,COG0205@2|Bacteria 2|Bacteria G 6-phosphofructokinase activity pfkA - 2.7.1.11,2.7.1.90 ko:K00850,ko:K21071 ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230 M00001,M00345 R00756,R00764,R02073,R03236,R03237,R03238,R03239,R04779 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000,ko01009,ko03019 - - iJN678.pfkA PFK k59_1058611_1 1121033.AUCF01000029_gene289 2.14e-80 246.0 COG3484@1|root,COG3484@2|Bacteria,1N057@1224|Proteobacteria,2U09K@28211|Alphaproteobacteria,2JRQ8@204441|Rhodospirillales 204441|Rhodospirillales O Proteasome-type protease - - - ko:K07395 - - - - ko00000 - - - Proteasome k59_1511476_1 1122137.AQXF01000006_gene893 4.3e-63 199.0 COG2003@1|root,COG2003@2|Bacteria,1MXZ5@1224|Proteobacteria,2TQXM@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Belongs to the UPF0758 family radC - - ko:K03630 - - - - ko00000 - - - RadC k59_1786486_1 316407.1736730 2.58e-124 358.0 COG1091@1|root,COG1091@2|Bacteria,1MUXM@1224|Proteobacteria,1RSNR@1236|Gammaproteobacteria,3XQ8Q@561|Escherichia 1236|Gammaproteobacteria F Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose rfbD GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0008831,GO:0009058,GO:0009059,GO:0009103,GO:0009987,GO:0016051,GO:0016491,GO:0016614,GO:0016616,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0045226,GO:0046379,GO:0055114,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 1.1.1.133 ko:K00067 ko00521,ko00523,ko01130,map00521,map00523,map01130 M00793 R02777 RC00182 ko00000,ko00001,ko00002,ko01000 - - iECSF_1327.ECSF_1929,iEcHS_1320.EcHS_A2180 RmlD_sub_bind k59_1676398_1 1123508.JH636453_gene5798 3.29e-34 127.0 COG3293@1|root,COG3293@2|Bacteria,2J0XQ@203682|Planctomycetes 203682|Planctomycetes L COGs COG3293 Transposase and inactivated derivatives - - - - - - - - - - - - DDE_Tnp_1_2,DUF4096 k59_1337301_1 1185876.BN8_01275 6.99e-66 220.0 COG0166@1|root,COG0166@2|Bacteria,4NDV0@976|Bacteroidetes,47JID@768503|Cytophagia 976|Bacteroidetes G Belongs to the GPI family pgi - 5.3.1.9 ko:K01810 ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200 M00001,M00004,M00114 R02739,R02740,R03321 RC00376,RC00563 ko00000,ko00001,ko00002,ko01000,ko04147 - - - PGI k59_772151_2 1121935.AQXX01000118_gene4925 2.12e-66 213.0 COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,1RMMJ@1236|Gammaproteobacteria 1236|Gammaproteobacteria I acyl-CoA dehydrogenase - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_721150_1 247490.KSU1_D0122 2.36e-58 190.0 COG0039@1|root,COG0039@2|Bacteria,2IY7S@203682|Planctomycetes 203682|Planctomycetes C Catalyzes the reversible oxidation of malate to oxaloacetate mdh - 1.1.1.37 ko:K00024 ko00020,ko00270,ko00620,ko00630,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00270,map00620,map00630,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740 R00342,R07136 RC00031 ko00000,ko00001,ko00002,ko01000 - - - Ldh_1_C,Ldh_1_N k59_998061_1 640511.BC1002_5272 3.4e-88 279.0 COG1154@1|root,COG1154@2|Bacteria,1MUSJ@1224|Proteobacteria,2VHXG@28216|Betaproteobacteria,1K2IB@119060|Burkholderiaceae 28216|Betaproteobacteria H Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) dxs - 2.2.1.7 ko:K01662 ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130 M00096 R05636 RC00032 ko00000,ko00001,ko00002,ko01000 - - - DXP_synthase_N,Transket_pyr,Transketolase_C k59_1569950_1 1238450.VIBNISOn1_1630010 5.08e-124 363.0 COG2801@1|root,COG2801@2|Bacteria,1MZ45@1224|Proteobacteria,1RSNX@1236|Gammaproteobacteria,1XWDU@135623|Vibrionales 135623|Vibrionales L COG2801 Transposase and inactivated derivatives - - - - - - - - - - - - HTH_29,rve k59_1569950_2 1440774.Y900_031070 0.0003 42.7 COG2801@1|root,COG2801@2|Bacteria,2GKDY@201174|Actinobacteria,237V0@1762|Mycobacteriaceae 201174|Actinobacteria L Transposase - GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K07497 - - - - ko00000 - - - HTH_21,rve,rve_3 k59_210603_1 1168065.DOK_11349 1.01e-129 382.0 COG0560@1|root,COG0560@2|Bacteria,1MWA3@1224|Proteobacteria,1RNJE@1236|Gammaproteobacteria,1J58R@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E phosphoserine phosphatase serB GO:0000287,GO:0001505,GO:0003674,GO:0003824,GO:0004647,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006544,GO:0006545,GO:0006563,GO:0006564,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0017144,GO:0019752,GO:0042133,GO:0042136,GO:0042578,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046872,GO:0065007,GO:0065008,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 3.1.3.3 ko:K01079 ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230 M00020 R00582 RC00017 ko00000,ko00001,ko00002,ko01000,ko01009 - - iE2348C_1286.E2348C_4686,iEC042_1314.EC042_4885,iECO26_1355.ECO26_5594,iECSF_1327.ECSF_4321,iECUMN_1333.ECUMN_5012,iETEC_1333.ETEC_4743,iPC815.YPO0442,iUMNK88_1353.UMNK88_5307 ACT_6,HAD,Hydrolase k59_326307_1 1380355.JNIJ01000047_gene229 1.34e-22 104.0 COG0515@1|root,COG2203@1|root,COG3899@1|root,COG4191@1|root,COG0515@2|Bacteria,COG2203@2|Bacteria,COG3899@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TQX3@28211|Alphaproteobacteria,3JR5W@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria T Histidine kinase-like ATPases - - - - - - - - - - - - AAA_16,GAF,GAF_2,HATPase_c,HisKA,PAS_9,Pkinase k59_1677450_1 497321.C664_16138 1.24e-48 155.0 COG1145@1|root,COG1145@2|Bacteria,1MZ6H@1224|Proteobacteria,2VTZ1@28216|Betaproteobacteria,2KX13@206389|Rhodocyclales 206389|Rhodocyclales C Ferredoxin - - - - - - - - - - - - Fer4 k59_544996_1 694430.Natoc_2652 2.48e-15 80.5 arCOG06159@1|root,arCOG06159@2157|Archaea,2XUHW@28890|Euryarchaeota,23U8Y@183963|Halobacteria 183963|Halobacteria L COG3385 FOG Transposase and inactivated derivatives - - - - - - - - - - - - DDE_Tnp_1 k59_607855_1 1443665.JACA01000007_gene238 3.44e-104 331.0 COG0584@1|root,COG4222@1|root,COG0584@2|Bacteria,COG4222@2|Bacteria,4NGI1@976|Bacteroidetes,1I0PI@117743|Flavobacteriia,2YGYQ@290174|Aquimarina 976|Bacteroidetes C Esterase-like activity of phytase glpQ - 3.1.4.46 ko:K01126 ko00564,map00564 - R01030,R01470 RC00017,RC00425 ko00000,ko00001,ko01000 - - - GDPD k59_1677453_1 1085623.GNIT_2827 5.72e-25 106.0 COG0845@1|root,COG0845@2|Bacteria,1MUFW@1224|Proteobacteria,1RQJ9@1236|Gammaproteobacteria,466HH@72275|Alteromonadaceae 1236|Gammaproteobacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - ko:K03585 ko01501,ko01503,map01501,map01503 M00646,M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000,ko03036 2.A.6.2,8.A.1.6 - - HlyD_D23 k59_42953_1 1411123.JQNH01000001_gene2483 7.91e-73 231.0 COG3055@1|root,COG3055@2|Bacteria,1QSB4@1224|Proteobacteria,2U0J2@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Kelch repeat protein - - - - - - - - - - - - Kelch_1,Kelch_2,Kelch_4,Kelch_6 k59_268238_1 391603.FBALC1_03382 1.85e-76 242.0 COG0168@1|root,COG0168@2|Bacteria,4NGMF@976|Bacteroidetes,1HXPV@117743|Flavobacteriia 976|Bacteroidetes P Trk-type K transport systems, membrane components trkH - - ko:K03498 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - - TrkH k59_1677454_1 317013.NY99_09640 3.35e-49 179.0 COG2352@1|root,COG2352@2|Bacteria,1MUD5@1224|Proteobacteria,1RPTP@1236|Gammaproteobacteria,1X4MI@135614|Xanthomonadales 135614|Xanthomonadales C Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle ppc GO:0003674,GO:0003824,GO:0004611,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008964,GO:0016829,GO:0016830,GO:0016831,GO:0044424,GO:0044444,GO:0044464 4.1.1.31 ko:K01595 ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200 M00168,M00170,M00171,M00172,M00173,M00346,M00374 R00345 RC02741 ko00000,ko00001,ko00002,ko01000 - - - PEPcase k59_326327_1 1122137.AQXF01000002_gene44 1.67e-40 146.0 28JAH@1|root,2Z95A@2|Bacteria,1MXKT@1224|Proteobacteria,2U1QQ@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Uncharacterised nucleotidyltransferase - - - - - - - - - - - - NTP_transf_5 k59_326327_2 1122137.AQXF01000002_gene45 5.42e-32 118.0 COG0546@1|root,COG0546@2|Bacteria,1RDDY@1224|Proteobacteria,2U79T@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress gph - 3.1.3.18 ko:K01091 ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130 - R01334 RC00017 ko00000,ko00001,ko01000 - - - HAD_2 k59_830864_1 316407.1651235 4.43e-82 248.0 COG2207@1|root,COG2207@2|Bacteria,1R8WH@1224|Proteobacteria,1S13W@1236|Gammaproteobacteria,3XQQ2@561|Escherichia 1236|Gammaproteobacteria K Porin thermoregulatory protein EnvY envY GO:0003674,GO:0003700,GO:0005575,GO:0006355,GO:0008150,GO:0009266,GO:0009628,GO:0009889,GO:0010468,GO:0010556,GO:0016020,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0140110,GO:1903506,GO:2000112,GO:2001141 - ko:K03755,ko:K11920 - - - - ko00000,ko03000 - - - HTH_18,HTH_AraC k59_1677479_1 1122137.AQXF01000001_gene3126 7.28e-86 260.0 COG1024@1|root,COG1024@2|Bacteria,1MVPQ@1224|Proteobacteria,2TTJ4@28211|Alphaproteobacteria 28211|Alphaproteobacteria I Enoyl-CoA hydratase MA20_32365 - - - - - - - - - - - ECH_1 k59_1677479_2 1267005.KB911260_gene3516 2.66e-19 80.5 COG2824@1|root,COG2824@2|Bacteria,1RGUU@1224|Proteobacteria,2UFDJ@28211|Alphaproteobacteria,3N7GS@45401|Hyphomicrobiaceae 28211|Alphaproteobacteria P PhnA domain phnA - - ko:K06193 ko01120,map01120 - - - ko00000 - - - PhnA,PhnA_Zn_Ribbon k59_98835_1 414996.IL38_07595 5.99e-111 333.0 COG0499@1|root,COG0499@2|Bacteria,2GK2Q@201174|Actinobacteria,407VI@622450|Actinopolysporales 201174|Actinobacteria H S-adenosyl-L-homocysteine hydrolase, NAD binding domain ahcY - 3.3.1.1 ko:K01251 ko00270,ko01100,map00270,map01100 M00035 R00192,R04936 RC00056,RC00069,RC01161,RC01243 ko00000,ko00001,ko00002,ko01000,ko01009,ko04147 - - - AdoHcyase,AdoHcyase_NAD k59_98835_2 909663.KI867150_gene2501 1.3e-21 88.6 COG1862@1|root,COG1862@2|Bacteria,1MZT2@1224|Proteobacteria,42V1U@68525|delta/epsilon subdivisions,2WR76@28221|Deltaproteobacteria,2MQKT@213462|Syntrophobacterales 28221|Deltaproteobacteria U TIGRFAM preprotein translocase, YajC subunit yajC - - ko:K03210 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2 - - YajC k59_98835_3 34506.g3105 1.52e-15 83.6 COG0343@1|root,KOG3908@2759|Eukaryota,38H9M@33154|Opisthokonta,3BB83@33208|Metazoa,3CT6A@33213|Bilateria,40C8R@6231|Nematoda,1KUK2@119089|Chromadorea,414R9@6236|Rhabditida 33208|Metazoa A Queuine tRNA-ribosyltransferase - - - - - - - - - - - - TGT k59_830868_1 317936.Nos7107_0990 2.44e-78 251.0 COG0318@1|root,COG0318@2|Bacteria,1G2H0@1117|Cyanobacteria,1HIDR@1161|Nostocales 1117|Cyanobacteria IQ Acyl-CoA synthetase (AMP-forming) AMP-acid ligase II - - 6.2.1.3 ko:K00666,ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding,AMP-binding_C k59_607882_1 203122.Sde_0122 3.7e-32 129.0 COG2304@1|root,COG2304@2|Bacteria,1MW8K@1224|Proteobacteria,1RNU3@1236|Gammaproteobacteria,46676@72275|Alteromonadaceae 1236|Gammaproteobacteria S protein containing a von Willebrand factor type A (vWA) domain - - - ko:K07114 - - - - ko00000,ko02000 1.A.13.2.2,1.A.13.2.3 - - VIT,VWA_3 k59_1450798_1 391625.PPSIR1_15980 3.56e-51 183.0 COG0515@1|root,COG2319@1|root,COG0515@2|Bacteria,COG2319@2|Bacteria,1MWJA@1224|Proteobacteria,42P8D@68525|delta/epsilon subdivisions,2WMH1@28221|Deltaproteobacteria,2YWWP@29|Myxococcales 28221|Deltaproteobacteria KLT COG0515 Serine threonine protein kinase - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - AAA_35,PD40,Pkinase,Pkinase_Tyr,WD40 k59_1622549_1 595460.RRSWK_00555 1.04e-66 228.0 COG3119@1|root,COG3291@1|root,COG3119@2|Bacteria,COG3291@2|Bacteria 2|Bacteria S metallopeptidase activity - - - - - - - - - - - - DUF1080,DUF4976,Dockerin_1,LRR_5,Sulfatase k59_1622549_2 190650.CC_0978 1.13e-116 367.0 COG3408@1|root,COG3408@2|Bacteria,1NJCP@1224|Proteobacteria,2U1JA@28211|Alphaproteobacteria,2KI0F@204458|Caulobacterales 204458|Caulobacterales G Bacterial alpha-L-rhamnosidase C-terminal domain - - 3.2.1.40 ko:K05989 - - - - ko00000,ko01000 - - - Bac_rhamnosid,Bac_rhamnosid6H,Bac_rhamnosid_C,Bac_rhamnosid_N k59_268276_2 667632.KB890173_gene3821 5.32e-27 107.0 COG3118@1|root,COG3118@2|Bacteria,1MV0R@1224|Proteobacteria,2VI6Z@28216|Betaproteobacteria,1K2GU@119060|Burkholderiaceae 28216|Betaproteobacteria O Thioredoxin - - - ko:K05838 - - - - ko00000,ko03110 - - - TPR_19,TPR_20,Thioredoxin k59_660438_1 472759.Nhal_2268 2.96e-42 149.0 COG3178@1|root,COG3178@2|Bacteria,1MXCH@1224|Proteobacteria,1RQ1Q@1236|Gammaproteobacteria,1X2FT@135613|Chromatiales 135613|Chromatiales S PFAM Aminoglycoside phosphotransferase - - 2.7.1.221 ko:K07102 ko00520,ko01100,map00520,map01100 - R08968,R11024 RC00002,RC00078 ko00000,ko00001,ko01000 - - - APH k59_660438_2 1485544.JQKP01000020_gene55 3.58e-18 81.6 COG1208@1|root,COG1208@2|Bacteria,1R9ZD@1224|Proteobacteria,2VJUN@28216|Betaproteobacteria,44V8V@713636|Nitrosomonadales 28216|Betaproteobacteria M Nucleotidyl transferase rmlA - 2.7.7.99 ko:K00992 ko00520,ko01100,map00520,map01100 - R11025 RC00002 ko00000,ko00001,ko01000 - - - NTP_transferase k59_1280829_1 880072.Desac_2596 1.09e-10 63.5 COG0741@1|root,COG0741@2|Bacteria,1MZ4X@1224|Proteobacteria,42TVX@68525|delta/epsilon subdivisions,2WP4F@28221|Deltaproteobacteria,2MQJV@213462|Syntrophobacterales 28221|Deltaproteobacteria M PFAM Lytic - - - ko:K08309 - - - - ko00000,ko01000,ko01011 - GH23 - DUF4124,SLT k59_383011_1 666685.R2APBS1_3815 9.93e-116 342.0 COG0535@1|root,COG0535@2|Bacteria,1MU07@1224|Proteobacteria,1RN94@1236|Gammaproteobacteria,1X8WG@135614|Xanthomonadales 135614|Xanthomonadales S Protein of unknown function (DUF3641) - - - - - - - - - - - - DUF3641,Radical_SAM k59_942195_1 1415778.JQMM01000001_gene1782 4.18e-159 471.0 COG0793@1|root,COG0793@2|Bacteria,1MU39@1224|Proteobacteria,1RMSR@1236|Gammaproteobacteria,1J57P@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Belongs to the peptidase S41A family prc GO:0003674,GO:0003824,GO:0004175,GO:0005575,GO:0005623,GO:0005886,GO:0006508,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0016020,GO:0016787,GO:0019538,GO:0023052,GO:0030163,GO:0030288,GO:0030313,GO:0031975,GO:0042221,GO:0042597,GO:0043170,GO:0044238,GO:0044464,GO:0046677,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901565,GO:1901575 3.4.21.102 ko:K03797 - - - - ko00000,ko01000,ko01002 - - - BAGE,DUF3340,PDZ,Peptidase_S41 k59_98853_1 1144305.PMI02_01082 1.92e-162 461.0 COG2141@1|root,COG2141@2|Bacteria,1MXZH@1224|Proteobacteria,2TQJH@28211|Alphaproteobacteria,2K3GK@204457|Sphingomonadales 204457|Sphingomonadales C Catalyzes the pyrimidine ring opening between N-3 and C- 4 by an unusual flavin hydroperoxide-catalyzed mechanism to yield ureidoacrylate peracid. It cleaves pyrmidine rings directly by adding oxygen atoms, making a toxic ureidoacrylate peracid product which can be spontaneously reduced to ureidoacrylate - - 1.14.99.46 ko:K09018 ko00240,ko01100,map00240,map01100 - R09936 RC02732 ko00000,ko00001,ko01000 - - - Bac_luciferase k59_1059338_1 1358423.N180_05275 8.46e-50 181.0 COG0616@1|root,COG0616@2|Bacteria,4NES1@976|Bacteroidetes,1IP6H@117747|Sphingobacteriia 976|Bacteroidetes OU signal peptide peptidase SppA, 67K type sppA - - ko:K04773 - - - - ko00000,ko01000,ko01002 - - - Peptidase_S49 k59_1280841_1 203119.Cthe_0039 0.000295 48.9 COG0840@1|root,COG0840@2|Bacteria,1TP5A@1239|Firmicutes,247S3@186801|Clostridia,3WIJV@541000|Ruminococcaceae 186801|Clostridia NT Four helix bundle sensory module for signal transduction - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - 4HB_MCP_1,HAMP,MCPsignal k59_1512456_1 314287.GB2207_04149 4.26e-14 72.4 COG3127@1|root,COG3127@2|Bacteria,1MU9R@1224|Proteobacteria,1RM8Y@1236|Gammaproteobacteria,1J4N8@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria Q ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component ybbP GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX k59_1512456_2 390235.PputW619_1759 3.3e-44 150.0 COG4181@1|root,COG4181@2|Bacteria,1MXG9@1224|Proteobacteria,1RMG1@1236|Gammaproteobacteria,1YW57@136845|Pseudomonas putida group 1236|Gammaproteobacteria Q ABC transporter ybbA GO:0000166,GO:0003674,GO:0005488,GO:0005524,GO:0008144,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_489902_1 1502851.FG93_00182 5.87e-46 169.0 COG0642@1|root,COG2203@1|root,COG5002@1|root,COG2203@2|Bacteria,COG2205@2|Bacteria,COG5002@2|Bacteria,1NRP8@1224|Proteobacteria,2TX3Q@28211|Alphaproteobacteria 28211|Alphaproteobacteria T Histidine kinase-like ATPases - - - - - - - - - - - - GAF,GAF_2,HAMP,HATPase_c,HisKA,Hpt,Response_reg,dCache_1 k59_1236005_1 1122137.AQXF01000003_gene2148 7.46e-269 752.0 COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,2TR3X@28211|Alphaproteobacteria 28211|Alphaproteobacteria S COG0488 ATPase components of ABC transporters with duplicated ATPase domains uup GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0008150,GO:0009314,GO:0009628,GO:0010528,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019219,GO:0019222,GO:0031323,GO:0044424,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051171,GO:0060255,GO:0065007,GO:0070894,GO:0071944,GO:0080090,GO:0097159,GO:1901363 - ko:K15738 - - - - ko00000,ko02000 3.A.1.120.6 - - ABC_tran,ABC_tran_CTD k59_1236005_3 1123355.JHYO01000012_gene676 1.83e-32 115.0 COG2119@1|root,COG2119@2|Bacteria,1N85A@1224|Proteobacteria,2UIGI@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Uncharacterized protein family UPF0016 - - - - - - - - - - - - UPF0016 k59_1236005_4 392500.Swoo_2240 2.83e-32 118.0 COG3791@1|root,COG3791@2|Bacteria,1NC41@1224|Proteobacteria,1SCYZ@1236|Gammaproteobacteria,2QE2D@267890|Shewanellaceae 1236|Gammaproteobacteria S Glutathione-dependent formaldehyde-activating - - - - - - - - - - - - GFA k59_108208_2 1408423.JHYA01000004_gene2191 1.49e-05 46.6 COG0172@1|root,COG0172@2|Bacteria,1TP4W@1239|Firmicutes,4H2SJ@909932|Negativicutes 909932|Negativicutes J Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) serS - 6.1.1.11 ko:K01875 ko00970,map00970 M00359,M00360 R03662,R08218 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Seryl_tRNA_N,tRNA-synt_2b k59_277906_2 1235794.C811_00123 0.000621 46.2 COG0791@1|root,COG0791@2|Bacteria,2HFK8@201174|Actinobacteria,4CXNR@84998|Coriobacteriia 84998|Coriobacteriia M NlpC/P60 family - - - ko:K21471 - - - - ko00000,ko01000,ko01002,ko01011 - - - NLPC_P60 k59_1290805_1 1123228.AUIH01000038_gene2751 1.51e-36 139.0 COG0260@1|root,COG0260@2|Bacteria,1MUF9@1224|Proteobacteria,1RNM1@1236|Gammaproteobacteria,1XH34@135619|Oceanospirillales 1236|Gammaproteobacteria E Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides - - - - - - - - - - - - Peptidase_M17 k59_162724_1 350058.Mvan_1263 2.27e-69 217.0 COG3914@1|root,COG3914@2|Bacteria,2IA30@201174|Actinobacteria,237SU@1762|Mycobacteriaceae 201174|Actinobacteria O Methyltransferase FkbM domain - - - - - - - - - - - - Methyltransf_21 k59_108215_1 469381.Dpep_2333 6.81e-44 151.0 COG0194@1|root,COG0194@2|Bacteria,3TB1Q@508458|Synergistetes 508458|Synergistetes F Essential for recycling GMP and indirectly, cGMP gmk - 2.7.4.8 ko:K00942 ko00230,ko01100,map00230,map01100 M00050 R00332,R02090 RC00002 ko00000,ko00001,ko00002,ko01000 - - - Guanylate_kin k59_1180260_1 765914.ThisiDRAFT_1983 1.12e-81 254.0 COG5008@1|root,COG5008@2|Bacteria,1QTTX@1224|Proteobacteria,1RN0B@1236|Gammaproteobacteria,1WX4M@135613|Chromatiales 135613|Chromatiales NU PFAM Type II secretion system protein E - - - ko:K02670 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE k59_1068560_1 236097.ADG881_347 1.04e-66 209.0 COG1881@1|root,COG1881@2|Bacteria,1N0Y4@1224|Proteobacteria,1RYVQ@1236|Gammaproteobacteria,1XR2C@135619|Oceanospirillales 135619|Oceanospirillales S COG1881 Phospholipid-binding protein - - - ko:K06910 - - - - ko00000 - - - PBP k59_498808_1 1121022.ABENE_17455 7.01e-26 107.0 COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,1R6VI@1224|Proteobacteria,2U4V7@28211|Alphaproteobacteria,2KIZJ@204458|Caulobacterales 204458|Caulobacterales EU WD40-like Beta Propeller Repeat - - - - - - - - - - - - PD40,Peptidase_S9 k59_952583_1 857087.Metme_1574 1.49e-14 79.0 COG1752@1|root,COG1752@2|Bacteria,1QJJS@1224|Proteobacteria,1THK7@1236|Gammaproteobacteria,1XENQ@135618|Methylococcales 135618|Methylococcales S Patatin-like phospholipase - - - - - - - - - - - - Patatin k59_952583_2 1380393.JHVP01000005_gene3508 2.56e-12 73.6 COG4235@1|root,COG4235@2|Bacteria,2IEIE@201174|Actinobacteria 201174|Actinobacteria O cytochrome complex assembly - - - - - - - - - - - - - k59_901741_1 1279017.AQYJ01000028_gene2183 5.01e-39 146.0 COG0811@1|root,COG0811@2|Bacteria,1MX5J@1224|Proteobacteria,1RMSA@1236|Gammaproteobacteria,4641Y@72275|Alteromonadaceae 1236|Gammaproteobacteria U MotA TolQ ExbB proton channel - - - ko:K03561 - - - - ko00000,ko02000 1.A.30.2.1 - - MotA_ExbB k59_1797653_1 301.JNHE01000010_gene3503 6.22e-119 352.0 COG2072@1|root,COG2072@2|Bacteria,1MWPJ@1224|Proteobacteria,1RNQP@1236|Gammaproteobacteria,1YEH6@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria P L-lysine 6-monooxygenase (NADPH-requiring) - - - ko:K07222 - - - - ko00000 - - - Pyr_redox_3 k59_1181094_2 1442599.JAAN01000033_gene1594 1.08e-12 64.7 COG0252@1|root,COG0252@2|Bacteria,1RHAW@1224|Proteobacteria,1S5WS@1236|Gammaproteobacteria,1X5DN@135614|Xanthomonadales 135614|Xanthomonadales EJ asparaginase VL23_12675 - 3.5.1.1 ko:K01424 ko00250,ko00460,ko01100,ko01110,map00250,map00460,map01100,map01110 - R00485 RC00010,RC02798 ko00000,ko00001,ko01000 - - - Asparaginase k59_393485_1 1232410.KI421426_gene1459 1.92e-49 171.0 COG0845@1|root,COG0845@2|Bacteria,1MU78@1224|Proteobacteria,42PGM@68525|delta/epsilon subdivisions,2X5J8@28221|Deltaproteobacteria,43SW4@69541|Desulfuromonadales 28221|Deltaproteobacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - ko:K03585 ko01501,ko01503,map01501,map01503 M00646,M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000,ko03036 2.A.6.2,8.A.1.6 - - Biotin_lipoyl_2,HlyD_3,HlyD_D23 k59_1688277_1 1122137.AQXF01000005_gene1140 4.6e-27 108.0 COG0498@1|root,COG0498@2|Bacteria,1MUWQ@1224|Proteobacteria,2TT0D@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Threonine synthase thrC - 4.2.3.1 ko:K01733 ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230 M00018 R01466,R05086 RC00017,RC00526 ko00000,ko00001,ko00002,ko01000 - - - PALP,Thr_synth_N k59_1688277_2 1122137.AQXF01000005_gene1139 7.53e-60 196.0 COG0612@1|root,COG0612@2|Bacteria,1MVST@1224|Proteobacteria,2TR39@28211|Alphaproteobacteria 28211|Alphaproteobacteria C Belongs to the peptidase M16 family mpp - - - - - - - - - - - Peptidase_M16,Peptidase_M16_C k59_1522698_2 1211114.ALIP01000134_gene1596 1.73e-33 124.0 COG1952@1|root,COG1952@2|Bacteria,1RI75@1224|Proteobacteria,1S62H@1236|Gammaproteobacteria,1X65X@135614|Xanthomonadales 135614|Xanthomonadales U One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA secB - - ko:K03071 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044,ko03110 3.A.5 - - SecB k59_1580339_1 1121937.AUHJ01000021_gene1432 2.86e-124 362.0 COG3039@1|root,COG3039@2|Bacteria,1MVDK@1224|Proteobacteria,1RR0T@1236|Gammaproteobacteria,46BKC@72275|Alteromonadaceae 1236|Gammaproteobacteria L DDE superfamily endonuclease - - - - - - - - - - - - DDE_Tnp_1,DUF772 k59_278827_1 1122137.AQXF01000001_gene2956 5.29e-81 253.0 COG0285@1|root,COG0285@2|Bacteria,1MVCH@1224|Proteobacteria,2TR64@28211|Alphaproteobacteria 28211|Alphaproteobacteria H Belongs to the folylpolyglutamate synthase family folC - 6.3.2.12,6.3.2.17 ko:K11754 ko00790,ko01100,map00790,map01100 M00126,M00841 R00942,R02237,R04241 RC00064,RC00090,RC00162 ko00000,ko00001,ko00002,ko01000 - - - Mur_ligase_M k59_278827_2 290633.GOX0626 2.04e-37 129.0 COG3118@1|root,COG3118@2|Bacteria,1MZBB@1224|Proteobacteria,2UCCR@28211|Alphaproteobacteria,2JSQZ@204441|Rhodospirillales 204441|Rhodospirillales O Belongs to the thioredoxin family trxA - - ko:K03671 ko04621,ko05418,map04621,map05418 - - - ko00000,ko00001,ko03110 - - - Thioredoxin k59_555532_1 247634.GPB2148_808 3.39e-11 62.8 COG0372@1|root,COG0372@2|Bacteria,1R9CW@1224|Proteobacteria,1RZXF@1236|Gammaproteobacteria,1J8A8@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Belongs to the citrate synthase family - - - - - - - - - - - - Citrate_synt k59_555532_2 765910.MARPU_15610 2.39e-64 202.0 2DBXS@1|root,2ZBR1@2|Bacteria,1RBUD@1224|Proteobacteria,1S1ZK@1236|Gammaproteobacteria,1X03Q@135613|Chromatiales 135613|Chromatiales - - - - - - - - - - - - - - - k59_278828_1 1121374.KB891590_gene1671 4.78e-83 265.0 COG2132@1|root,COG2132@2|Bacteria,1MU0J@1224|Proteobacteria,1RQ4N@1236|Gammaproteobacteria 1236|Gammaproteobacteria Q Multi-copper pcoA - - - - - - - - - - - CopB,Cu-oxidase,Cu-oxidase_2,Cu-oxidase_3 k59_1291707_1 1336208.JADY01000010_gene3319 7.8e-70 225.0 COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2TRI3@28211|Alphaproteobacteria 28211|Alphaproteobacteria C Belongs to the aldehyde dehydrogenase family ligV - 1.2.1.67 ko:K21802 ko00627,ko01120,map00627,map01120 - R05699 RC00075 ko00000,ko00001,ko01000 - - - Aldedh k59_1291707_2 1168065.DOK_12306 6.65e-192 536.0 COG3618@1|root,COG3618@2|Bacteria,1N2QM@1224|Proteobacteria,1RQ8V@1236|Gammaproteobacteria,1J5VK@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S metal-dependent hydrolase of the TIM-barrel fold - - 3.1.1.57 ko:K10221 ko00362,ko00627,ko01120,map00362,map00627,map01120 - R04277 RC03110 ko00000,ko00001,ko01000 - - - Amidohydro_2 k59_1461400_1 435591.BDI_3044 4.81e-15 83.2 COG3209@1|root,COG4290@1|root,COG3209@2|Bacteria,COG4290@2|Bacteria,4NGJF@976|Bacteroidetes,2FQPQ@200643|Bacteroidia,22VUM@171551|Porphyromonadaceae 976|Bacteroidetes M RHS repeat-associated core domain protein - - - - - - - - - - - - RHS_repeat,Ribonuclease,SpvB,TcdB_toxin_midN,VCBS k59_1688293_1 69395.JQLZ01000014_gene4014 1.13e-89 290.0 COG1472@1|root,COG1472@2|Bacteria,1MVIV@1224|Proteobacteria,2U23T@28211|Alphaproteobacteria,2KHWR@204458|Caulobacterales 204458|Caulobacterales G PA14 - - 3.2.1.21 ko:K05349 ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110 - R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040 RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248 ko00000,ko00001,ko01000 - GH3 - Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C,PA14 k59_952639_1 1089553.Tph_c09340 1.1e-20 95.5 COG0587@1|root,COG0587@2|Bacteria,1TPYG@1239|Firmicutes,247U0@186801|Clostridia,42EPB@68295|Thermoanaerobacterales 186801|Clostridia L TIGRFAM DNA polymerase III, alpha subunit dnaE - 2.7.7.7 ko:K02337,ko:K14162 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon k59_220766_1 644282.Deba_0587 3.98e-150 451.0 COG0038@1|root,COG2905@1|root,COG0038@2|Bacteria,COG2905@2|Bacteria,1MV4K@1224|Proteobacteria,42N93@68525|delta/epsilon subdivisions,2WJ9N@28221|Deltaproteobacteria 28221|Deltaproteobacteria P PFAM Cl- channel voltage-gated family protein - - - ko:K03281 - - - - ko00000 2.A.49 - - CBS,Voltage_CLC k59_841547_1 1088721.NSU_2463 2.58e-47 163.0 COG0454@1|root,COG0456@2|Bacteria,1PMA3@1224|Proteobacteria,2TUU2@28211|Alphaproteobacteria,2K0BS@204457|Sphingomonadales 204457|Sphingomonadales K acetyltransferase - - - - - - - - - - - - - k59_841547_2 1088721.NSU_2462 1.6e-21 94.0 COG3239@1|root,COG3239@2|Bacteria,1MVY5@1224|Proteobacteria,2U156@28211|Alphaproteobacteria,2K0CR@204457|Sphingomonadales 204457|Sphingomonadales I Fatty acid desaturase - - - - - - - - - - - - FA_desaturase k59_499726_1 301.JNHE01000033_gene979 1.14e-79 249.0 COG2256@1|root,COG2256@2|Bacteria,1MUVS@1224|Proteobacteria,1RPBY@1236|Gammaproteobacteria,1YDJT@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria L AAA C-terminal domain rarA GO:0005575,GO:0005622,GO:0005623,GO:0005657,GO:0005694,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006310,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0030894,GO:0032991,GO:0032993,GO:0034641,GO:0034645,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044422,GO:0044424,GO:0044427,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901576 - ko:K07478 - - - - ko00000 - - - AAA,AAA_assoc_2,MgsA_C,RuvB_N k59_555546_1 326423.RBAM_035140 1.31e-32 127.0 COG0399@1|root,COG0399@2|Bacteria,1TPDH@1239|Firmicutes,4HDN8@91061|Bacilli,1ZQW8@1386|Bacillus 91061|Bacilli E Belongs to the DegT DnrJ EryC1 family spsC - 2.6.1.102 ko:K13010 ko00520,map00520 - R10460 RC00006,RC00781 ko00000,ko00001,ko01000,ko01005,ko01007 - - - DegT_DnrJ_EryC1 k59_1236866_1 331869.BAL199_12636 5.9e-56 186.0 COG3039@1|root,COG3039@2|Bacteria,1MUVI@1224|Proteobacteria,2TSA7@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Transposase - - - - - - - - - - - - DDE_Tnp_1,DDE_Tnp_1_6,DUF772 k59_1236877_1 1458427.BAWN01000015_gene992 1.78e-107 315.0 28HYK@1|root,2Z83Z@2|Bacteria,1MY0H@1224|Proteobacteria,2W10U@28216|Betaproteobacteria 28216|Betaproteobacteria S Protein of unknown function (DUF3800) - - - - - - - - - - - - DUF3800 k59_555555_2 1122915.AUGY01000063_gene4184 4.23e-12 65.1 COG1208@1|root,COG1208@2|Bacteria,1VDBC@1239|Firmicutes,4IS8X@91061|Bacilli,277CZ@186822|Paenibacillaceae 91061|Bacilli JM Nucleotidyl transferase - - - - - - - - - - - - Hydrolase_like,NTP_transferase k59_1291736_1 436308.Nmar_1628 3.26e-124 376.0 COG0640@1|root,COG1328@1|root,arCOG00734@2157|Archaea,arCOG04889@2157|Archaea,41SBG@651137|Thaumarchaeota 651137|Thaumarchaeota FK Anaerobic ribonucleoside-triphosphate reductase - - 1.1.98.6 ko:K21636 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R11633,R11634,R11635,R11636 RC00613 ko00000,ko00001,ko00002,ko01000 - - - ATP-cone,HTH_20,NRDD k59_841579_1 1178825.ALIH01000005_gene130 2.79e-86 262.0 COG4974@1|root,COG4974@2|Bacteria,4NE0E@976|Bacteroidetes,1HYPM@117743|Flavobacteriia 976|Bacteroidetes L Tyrosine recombinase XerC xerC - - ko:K04763 - - - - ko00000,ko03036 - - - Phage_int_SAM_1,Phage_integrase k59_952677_1 258533.BN977_06297 1.3e-57 197.0 COG2072@1|root,COG2072@2|Bacteria,2GKYU@201174|Actinobacteria,234M3@1762|Mycobacteriaceae 201174|Actinobacteria P flavoprotein involved in K transport - - 1.14.13.22 ko:K03379 ko00930,ko01120,ko01220,map00930,map01120,map01220 - R02231,R06622 RC00662,RC01550 ko00000,ko00001,ko01000 - - - FMO-like,NAD_binding_8,Pyr_redox_2,Pyr_redox_3 k59_1633155_1 1027396.LMOSA_26800 6.47e-13 73.6 COG0210@1|root,COG0210@2|Bacteria,1TPSU@1239|Firmicutes,4HB12@91061|Bacilli,26K20@186820|Listeriaceae 91061|Bacilli L ATP-dependent DNA helicase pcrA - 3.6.4.12 ko:K03657 ko03420,ko03430,map03420,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - UvrD-helicase,UvrD_C k59_1522761_1 228410.NE2402 2.36e-134 405.0 COG0542@1|root,COG0542@2|Bacteria,1MURH@1224|Proteobacteria,2VHYF@28216|Betaproteobacteria,371VX@32003|Nitrosomonadales 28216|Betaproteobacteria O Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE clpB - - ko:K03695 ko04213,map04213 - - - ko00000,ko00001,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N k59_1236908_1 530564.Psta_1385 8.74e-24 98.2 COG3298@1|root,COG3298@2|Bacteria,2IWT7@203682|Planctomycetes 203682|Planctomycetes L 3'-5' exonuclease related to the exonuclease domain of PolB - - - ko:K07501 - - - - ko00000 - - - DNA_pol_B_exo2 k59_1522764_1 472175.EL18_02408 8.44e-98 293.0 28JXP@1|root,2Z9N4@2|Bacteria,1MXG4@1224|Proteobacteria,2TSXI@28211|Alphaproteobacteria,43HHP@69277|Phyllobacteriaceae 28211|Alphaproteobacteria S Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family MA20_24470 - - - - - - - - - - - Peptidase_C92 k59_53240_1 72019.SARC_04465T0 0.000773 44.3 KOG0118@1|root,KOG0118@2759|Eukaryota 2759|Eukaryota H RNA binding - GO:0003674,GO:0003676,GO:0003723,GO:0003727,GO:0003729,GO:0003730,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005844,GO:0006139,GO:0006396,GO:0006397,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008187,GO:0008266,GO:0008283,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0030154,GO:0031974,GO:0031981,GO:0032502,GO:0032991,GO:0034046,GO:0034641,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0044237,GO:0044238,GO:0044422,GO:0044424,GO:0044428,GO:0044444,GO:0044446,GO:0044464,GO:0046483,GO:0048468,GO:0048856,GO:0048863,GO:0048864,GO:0048869,GO:0070013,GO:0070717,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990904 - ko:K12741,ko:K14411 ko03015,ko03040,map03015,map03040 - - - ko00000,ko00001,ko03019,ko03041 - - - RRM_1 k59_109247_1 1229909.NSED_03350 6.01e-71 220.0 COG0388@1|root,arCOG00062@2157|Archaea 2157|Archaea H Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase - - 3.5.1.3 ko:K13566 ko00250,map00250 - R00269,R00348 RC00010 ko00000,ko00001,ko01000 - - - CN_hydrolase k59_336512_1 1219045.BV98_001287 3.62e-08 59.3 COG1960@1|root,COG1960@2|Bacteria,1MVJC@1224|Proteobacteria,2TQRA@28211|Alphaproteobacteria,2K01U@204457|Sphingomonadales 204457|Sphingomonadales I acyl-CoA dehydrogenase - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_1580387_1 1231190.NA8A_09394 2.87e-08 53.9 COG0558@1|root,COG0558@2|Bacteria,1MZ8B@1224|Proteobacteria,2U7AP@28211|Alphaproteobacteria,43JVR@69277|Phyllobacteriaceae 28211|Alphaproteobacteria I Belongs to the CDP-alcohol phosphatidyltransferase class-I family MA20_28295 - 2.7.8.41,2.7.8.5 ko:K00995,ko:K08744 ko00564,ko01100,map00564,map01100 - R01801,R02030 RC00002,RC00017,RC02795 ko00000,ko00001,ko01000 - - - CDP-OH_P_transf k59_1580387_2 948106.AWZT01000006_gene3243 3.21e-30 116.0 COG0150@1|root,COG0150@2|Bacteria,1MURG@1224|Proteobacteria,2VHJT@28216|Betaproteobacteria,1K2VU@119060|Burkholderiaceae 28216|Betaproteobacteria F Phosphoribosylformylglycinamidine cyclo-ligase purM - 6.3.3.1 ko:K01933 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04208 RC01100 ko00000,ko00001,ko00002,ko01000 - - - AIRS,AIRS_C k59_1181170_1 395493.BegalDRAFT_2410 1.09e-124 376.0 COG0376@1|root,COG0376@2|Bacteria,1MUBF@1224|Proteobacteria,1RNA5@1236|Gammaproteobacteria,4605A@72273|Thiotrichales 72273|Thiotrichales P Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity katG - 1.11.1.21 ko:K03782 ko00360,ko00380,ko00940,ko00983,ko01100,ko01110,map00360,map00380,map00940,map00983,map01100,map01110 - R00602,R00698,R02596,R02670,R03919,R04007,R07443,R11906 RC00034,RC00213,RC00767,RC02141 ko00000,ko00001,ko01000 - - - peroxidase k59_1008097_1 1190603.AJYD01000039_gene2922 1.12e-09 64.3 COG0583@1|root,COG0583@2|Bacteria,1R5BA@1224|Proteobacteria,1S4S1@1236|Gammaproteobacteria,1XT26@135623|Vibrionales 135623|Vibrionales K Transcriptional regulator aphB - - ko:K10918 ko05111,map05111 - - - ko00000,ko00001,ko03000 - - - HTH_1,LysR_substrate k59_1008097_2 1479235.KK366039_gene888 6.23e-23 98.6 COG0006@1|root,COG0006@2|Bacteria,1MURT@1224|Proteobacteria,1RMKT@1236|Gammaproteobacteria,1XHWX@135619|Oceanospirillales 135619|Oceanospirillales E Splits dipeptides with a prolyl residue in the C- terminal position pepQ - 3.4.13.9 ko:K01271 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M24 k59_952710_1 1453501.JELR01000001_gene2864 3.09e-52 185.0 COG0457@1|root,COG0457@2|Bacteria,1MX2U@1224|Proteobacteria,1RPD2@1236|Gammaproteobacteria,464NG@72275|Alteromonadaceae 1236|Gammaproteobacteria C Cytochrome c554 and c-prime - - - - - - - - - - - - Cytochrome_C554,HEAT_2,Paired_CXXCH_1,TPR_16,TPR_19,TPR_20,TPR_8 k59_1122450_1 316407.85675977 4.5e-134 387.0 COG0536@1|root,COG0536@2|Bacteria,1MUGZ@1224|Proteobacteria,1RMFQ@1236|Gammaproteobacteria,3XNNJ@561|Escherichia 1236|Gammaproteobacteria S An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control obg GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006996,GO:0007059,GO:0008150,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019003,GO:0022607,GO:0022611,GO:0022613,GO:0022618,GO:0032502,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034622,GO:0035639,GO:0036094,GO:0042254,GO:0042255,GO:0043021,GO:0043023,GO:0043167,GO:0043168,GO:0043933,GO:0044085,GO:0044087,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0065003,GO:0065007,GO:0070925,GO:0071826,GO:0071840,GO:0090069,GO:0090071,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - ko:K03979 - - - - ko00000,ko01000,ko03009 - - - GTP1_OBG,MMR_HSR1 k59_278889_2 1121937.AUHJ01000010_gene1688 2.94e-89 274.0 COG0477@1|root,COG2814@2|Bacteria,1MVSH@1224|Proteobacteria,1RYB9@1236|Gammaproteobacteria,467YJ@72275|Alteromonadaceae 1236|Gammaproteobacteria EGP Sugar (and other) transporter tetA - - ko:K08151 - M00668 - - ko00000,ko00002,ko01504,ko02000 2.A.1.2.38,2.A.1.2.39,2.A.1.2.4,2.A.1.2.41,2.A.1.2.68,2.A.1.2.75 - - MFS_1,Sugar_tr k59_841640_1 391603.FBALC1_03712 3.76e-50 169.0 COG0057@1|root,COG0057@2|Bacteria,4NEMF@976|Bacteroidetes,1HXVU@117743|Flavobacteriia 976|Bacteroidetes G Belongs to the glyceraldehyde-3-phosphate dehydrogenase family gap - 1.2.1.12 ko:K00134 ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01061 RC00149 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - Gp_dh_C,Gp_dh_N k59_841640_2 983544.Lacal_1443 4.71e-76 234.0 COG0320@1|root,COG0320@2|Bacteria,4NEB5@976|Bacteroidetes,1HXXW@117743|Flavobacteriia 976|Bacteroidetes H Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives lipA - 2.8.1.8 ko:K03644 ko00785,ko01100,map00785,map01100 - R07767,R07768 RC01978 ko00000,ko00001,ko01000 - - - LIAS_N,Radical_SAM k59_555606_1 316407.1799599 6.1e-90 275.0 COG2271@1|root,COG2271@2|Bacteria,1MUEK@1224|Proteobacteria,1RMB4@1236|Gammaproteobacteria,3XNKV@561|Escherichia 1236|Gammaproteobacteria P transmembrane transport rhmT GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - - - - - - - - - iAPECO1_1312.APECO1_4315,iUTI89_1310.UTI89_C2528,ic_1306.c2788 MFS_1 k59_555606_2 316407.85675322 2.6e-52 171.0 COG3836@1|root,COG3836@2|Bacteria,1MUSG@1224|Proteobacteria,1RMWJ@1236|Gammaproteobacteria,3XNDD@561|Escherichia 1236|Gammaproteobacteria H Catalyzes the reversible retro-aldol cleavage of 2-keto- 3-deoxy-L-rhamnonate (KDR) to pyruvate and lactaldehyde rhmA GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0006725,GO:0008150,GO:0008152,GO:0009987,GO:0016151,GO:0016829,GO:0016830,GO:0016832,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046872,GO:0046914,GO:0071704 4.1.2.52,4.1.2.53 ko:K02510,ko:K12660 ko00051,ko00350,ko01120,map00051,map00350,map01120 - R01645,R01647,R02261 RC00307,RC00435,RC00572,RC00574,RC03057 ko00000,ko00001,ko01000 - - iSBO_1134.SBO_2049 HpcH_HpaI k59_782151_1 765913.ThidrDRAFT_0733 3.88e-28 112.0 COG0796@1|root,COG0796@2|Bacteria,1NAI2@1224|Proteobacteria,1RPU9@1236|Gammaproteobacteria,1WW6Z@135613|Chromatiales 135613|Chromatiales M Provides the (R)-glutamate required for cell wall biosynthesis murI - 5.1.1.3 ko:K01776 ko00471,ko01100,map00471,map01100 - R00260 RC00302 ko00000,ko00001,ko01000,ko01011 - - - Asp_Glu_race k59_782151_2 1306174.JODP01000006_gene3453 9.53e-60 197.0 COG0345@1|root,COG0345@2|Bacteria,2GJ7D@201174|Actinobacteria 201174|Actinobacteria E Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline proC GO:0000287,GO:0003674,GO:0003824,GO:0004735,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016020,GO:0016053,GO:0016491,GO:0016645,GO:0016646,GO:0018130,GO:0019752,GO:0030145,GO:0040007,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046483,GO:0046872,GO:0046914,GO:0055114,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.5.1.2 ko:K00286 ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230 M00015 R01248,R01251,R03291,R03293 RC00054,RC00083 ko00000,ko00001,ko00002,ko01000 - - - F420_oxidored,P5CR_dimer k59_1236939_1 269799.Gmet_1255 0.000139 50.1 COG4589@1|root,COG4589@2|Bacteria,1R34Q@1224|Proteobacteria,42QTH@68525|delta/epsilon subdivisions,2WQ6V@28221|Deltaproteobacteria,43SXU@69541|Desulfuromonadales 28221|Deltaproteobacteria M PFAM phosphatidate cytidylyltransferase cdsA - 2.7.7.41 ko:K00981 ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070 M00093 R01799 RC00002 ko00000,ko00001,ko00002,ko01000 - - - CTP_transf_1 k59_109275_1 765914.ThisiDRAFT_0870 2.25e-06 54.7 COG5002@1|root,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,1T1JE@1236|Gammaproteobacteria 1236|Gammaproteobacteria T Histidine kinase - - - - - - - - - - - - CHASE,HATPase_c,HisKA,Hpt,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg,dCache_3 k59_53277_1 1333523.L593_04100 2.71e-13 75.5 COG3291@1|root,arCOG02546@2157|Archaea 2157|Archaea M protein contain chitin-binding domain type 3 - - 3.2.1.14,3.2.1.202 ko:K01183,ko:K21606 ko00520,ko01100,map00520,map01100 - R01206,R02334 RC00467 ko00000,ko00001,ko01000 - CBM5,GH18 - CARDB,Glyco_hydro_18,Malectin,PKD k59_901841_1 765910.MARPU_00630 1.63e-120 353.0 COG0714@1|root,COG0714@2|Bacteria,1MUFN@1224|Proteobacteria,1RP45@1236|Gammaproteobacteria,1WXIF@135613|Chromatiales 135613|Chromatiales S associated with various cellular activities - - - ko:K03924 - - - - ko00000,ko01000 - - - AAA_3 k59_841667_1 1033730.CAHG01000012_gene2265 1.51e-23 106.0 COG0767@1|root,COG1127@1|root,COG0767@2|Bacteria,COG1127@2|Bacteria,2GXR8@201174|Actinobacteria,4DU72@85009|Propionibacteriales 201174|Actinobacteria Q Permease MlaE yrbE4A - - ko:K02066 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - MlaE k59_670747_1 1123501.KB902280_gene433 1.68e-23 96.7 COG1173@1|root,COG1173@2|Bacteria,1MU0P@1224|Proteobacteria,2TSX5@28211|Alphaproteobacteria 28211|Alphaproteobacteria P COG1173 ABC-type dipeptide oligopeptide nickel transport systems permease components - - - ko:K02034 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1,OppC_N k59_670747_2 1123360.thalar_01575 2e-25 104.0 COG5486@1|root,COG5486@2|Bacteria,1NFSK@1224|Proteobacteria,2U4IW@28211|Alphaproteobacteria 28211|Alphaproteobacteria S metal-binding integral membrane protein - - - - - - - - - - - - DUF2182 k59_499794_1 883.DvMF_3084 6.25e-88 283.0 COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,42M9W@68525|delta/epsilon subdivisions,2WJ29@28221|Deltaproteobacteria,2M832@213115|Desulfovibrionales 28221|Deltaproteobacteria O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner lon-3 - 3.4.21.53 ko:K01338 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - AAA,LON_substr_bdg,Lon_C k59_731929_1 795359.TOPB45_0035 1.07e-29 116.0 COG0767@1|root,COG0767@2|Bacteria,2GH54@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria Q Permease MlaE - - - ko:K02066 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - MlaE k59_841685_1 199310.c4744 2.39e-192 547.0 COG0514@1|root,COG0514@2|Bacteria,1MVGG@1224|Proteobacteria,1RMPG@1236|Gammaproteobacteria,3XNKI@561|Escherichia 1236|Gammaproteobacteria L ATP-dependent DNA helicase recQ GO:0003674,GO:0003676,GO:0003677,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005657,GO:0005694,GO:0005737,GO:0006139,GO:0006259,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0008270,GO:0009295,GO:0009378,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017116,GO:0017117,GO:0030894,GO:0032392,GO:0032508,GO:0032991,GO:0032993,GO:0033202,GO:0033554,GO:0034641,GO:0042623,GO:0043138,GO:0043140,GO:0043142,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043590,GO:0044237,GO:0044238,GO:0044260,GO:0044422,GO:0044424,GO:0044427,GO:0044446,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0050896,GO:0051276,GO:0051716,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1902494,GO:1904949 3.6.4.12 ko:K03654 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,HRDC,Helicase_C,RQC,RecQ_Zn_bind k59_163671_1 1476876.JOJO01000008_gene2722 7.1e-05 44.7 COG4221@1|root,COG4221@2|Bacteria,2GP05@201174|Actinobacteria 201174|Actinobacteria L Belongs to the short-chain dehydrogenases reductases (SDR) family - - - ko:K12677 ko00331,ko01130,map00331,map01130 - R05471 RC00649 ko00000,ko00001 - - - adh_short k59_65226_1 1202532.FF52_22264 1.28e-61 211.0 COG1239@1|root,COG1239@2|Bacteria,4PMD7@976|Bacteroidetes,1I7K7@117743|Flavobacteriia,2P0W4@237|Flavobacterium 976|Bacteroidetes H Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX - - - - - - - - - - - - - k59_1420145_1 1229909.NSED_07845 6.09e-85 257.0 COG0084@1|root,arCOG00891@2157|Archaea,41SGP@651137|Thaumarchaeota 651137|Thaumarchaeota L TatD related DNase - - - ko:K03424 - - - - ko00000,ko01000 - - - TatD_DNase k59_65231_1 1828.JOKB01000028_gene2166 1.13e-06 56.6 COG2909@1|root,COG3629@1|root,COG2909@2|Bacteria,COG3629@2|Bacteria,2GJAR@201174|Actinobacteria,4G9EW@85025|Nocardiaceae 201174|Actinobacteria KT Bacterial transcriptional activator domain - - - - - - - - - - - - AAA_16,BTAD,Trans_reg_C k59_1759418_1 221288.JH992901_gene3895 4.76e-52 179.0 COG0715@1|root,COG0715@2|Bacteria,1GFIM@1117|Cyanobacteria 1117|Cyanobacteria P Protein of unknown function (DUF3500) - - - - - - - - - - - - DUF3500 k59_1137873_1 1120956.JHZK01000027_gene1193 1.09e-57 189.0 COG1575@1|root,COG1575@2|Bacteria,1MXQQ@1224|Proteobacteria,2UAN7@28211|Alphaproteobacteria 28211|Alphaproteobacteria H UbiA prenyltransferase family - - 2.5.1.74 ko:K02548 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116 R05617,R06858,R10757 RC02935,RC02936,RC03264 ko00000,ko00001,ko00002,ko01000,ko01006 - - - UbiA k59_685785_1 1231185.BAMP01000009_gene2280 2.8e-29 123.0 COG2304@1|root,COG2931@1|root,COG2304@2|Bacteria,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,2U1YP@28211|Alphaproteobacteria 28211|Alphaproteobacteria Q COG2931, RTX toxins and related Ca2 -binding proteins - - - - - - - - - - - - VWA,VWA_2 k59_968324_1 298655.KI912267_gene7945 4.24e-26 107.0 COG0578@1|root,COG0578@2|Bacteria,2GJKN@201174|Actinobacteria,4ES07@85013|Frankiales 201174|Actinobacteria C Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family - - 1.1.5.3 ko:K00111 ko00564,ko01110,map00564,map01110 - R00848 RC00029 ko00000,ko00001,ko01000 - - - DAO,DAO_C k59_968324_2 502025.Hoch_3811 1.12e-12 70.5 COG0730@1|root,COG0730@2|Bacteria,1MXNM@1224|Proteobacteria,42KZF@68525|delta/epsilon subdivisions,2WMFY@28221|Deltaproteobacteria,2Z2XR@29|Myxococcales 28221|Deltaproteobacteria S Sulfite exporter TauE/SafE - - - ko:K07090 - - - - ko00000 - - - TauE k59_177492_1 557599.MKAN_03615 2.13e-45 160.0 COG0493@1|root,COG0493@2|Bacteria,2GJ0A@201174|Actinobacteria,236N6@1762|Mycobacteriaceae 201174|Actinobacteria C glutamate synthase preT - - - - - - - - - - - Fer4,Fer4_20,Pyr_redox_2,Pyr_redox_3 k59_177492_2 243233.MCA0769 2.31e-29 115.0 COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1146@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1146@2|Bacteria,1MVM0@1224|Proteobacteria,1RNNX@1236|Gammaproteobacteria,1XE3B@135618|Methylococcales 135618|Methylococcales C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin - - 1.2.7.1 ko:K03737 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00173,M00307 R01196,R10866 RC00004,RC02742 br01601,ko00000,ko00001,ko00002,ko01000 - - - EKR,Fer4_16,PFOR_II,POR,POR_N,TPP_enzyme_C k59_1081577_1 349124.Hhal_1016 2.52e-70 225.0 COG3608@1|root,COG3608@2|Bacteria,1R784@1224|Proteobacteria,1RRY6@1236|Gammaproteobacteria,1WWYR@135613|Chromatiales 135613|Chromatiales S PFAM Succinylglutamate desuccinylase Aspartoacylase - - - - - - - - - - - - AstE_AspA k59_742712_1 1123393.KB891331_gene2925 5.92e-61 203.0 COG1032@1|root,COG1032@2|Bacteria 2|Bacteria C radical SAM domain protein - - - - - - - - - - - - B12-binding,Radical_SAM k59_1137877_1 671143.DAMO_3166 2.69e-26 110.0 COG0845@1|root,COG0845@2|Bacteria,2NPBH@2323|unclassified Bacteria 2|Bacteria M Barrel-sandwich domain of CusB or HlyD membrane-fusion macA_1 - - ko:K02005,ko:K13888 - M00709 - - ko00000,ko00002,ko02000 8.A.1 - - HlyD_D23 k59_1477460_1 1122137.AQXF01000006_gene779 4.94e-36 132.0 COG3087@1|root,COG3087@2|Bacteria,1MXII@1224|Proteobacteria,2TTG3@28211|Alphaproteobacteria 28211|Alphaproteobacteria D sporulation - - - - - - - - - - - - SPOR k59_1533687_1 1042377.AFPJ01000020_gene2099 2.64e-134 391.0 COG0715@1|root,COG0715@2|Bacteria,1MWDN@1224|Proteobacteria,1RPUP@1236|Gammaproteobacteria,465AR@72275|Alteromonadaceae 1236|Gammaproteobacteria P COG0715 ABC-type nitrate sulfonate bicarbonate transport systems, periplasmic components nrtC - - ko:K15576 ko00910,ko02010,map00910,map02010 M00438 - - ko00000,ko00001,ko00002,ko02000 3.A.1.16.1,3.A.1.16.2 - - NMT1_2 k59_856040_1 395495.Lcho_1988 1.25e-87 278.0 COG1529@1|root,COG1529@2|Bacteria,1QTTJ@1224|Proteobacteria,2VHB9@28216|Betaproteobacteria,1KJ3Z@119065|unclassified Burkholderiales 28216|Betaproteobacteria C Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL CutL-like protein - - 1.3.99.16 ko:K07303 - - - - ko00000,ko01000 - - - Ald_Xan_dh_C,Ald_Xan_dh_C2 k59_516219_1 710696.Intca_0768 4.04e-13 67.0 2AWFS@1|root,31NC1@2|Bacteria,2IMS0@201174|Actinobacteria,4FH76@85021|Intrasporangiaceae 201174|Actinobacteria - - - - - - - - - - - - - - - k59_516219_2 1323663.AROI01000002_gene1227 1.01e-09 62.4 COG2335@1|root,COG2335@2|Bacteria,1RD06@1224|Proteobacteria,1RSMY@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Secreted and surface protein containing fasciclin-like repeats - - - - - - - - - - - - Fasciclin k59_799722_2 686578.AFFX01000005_gene4287 4.17e-61 203.0 COG0130@1|root,COG0130@2|Bacteria,1MV0N@1224|Proteobacteria,1RMKP@1236|Gammaproteobacteria 1236|Gammaproteobacteria J Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs truB GO:0000049,GO:0001522,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016556,GO:0016853,GO:0016866,GO:0031119,GO:0034337,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990481 5.4.99.25 ko:K03177 - - - - ko00000,ko01000,ko03016 - - - TruB-C_2,TruB_C_2,TruB_N k59_1759444_1 926569.ANT_15620 1.24e-52 181.0 COG1122@1|root,COG1122@2|Bacteria,2G5RY@200795|Chloroflexi 200795|Chloroflexi P PFAM ABC transporter related - - - ko:K16786,ko:K16787 ko02010,map02010 M00582 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35 - - ABC_tran k59_8611_1 1123401.JHYQ01000041_gene3214 3.85e-62 198.0 COG3128@1|root,COG3128@2|Bacteria,1MUI7@1224|Proteobacteria,1RQ0M@1236|Gammaproteobacteria,460NQ@72273|Thiotrichales 72273|Thiotrichales S PFAM 2OG-Fe(II) oxygenase superfamily - - - ko:K07336 - - - - ko00000,ko01000 - - - 2OG-FeII_Oxy_3 k59_685830_1 298654.FraEuI1c_1474 1.05e-143 419.0 COG1012@1|root,COG1012@2|Bacteria 2|Bacteria C belongs to the aldehyde dehydrogenase family luxC - 1.2.1.50 ko:K03400 ko02020,ko02024,map02020,map02024 - R10549 RC00004,RC00184 ko00000,ko00001,ko01000 - - - LuxC k59_1420176_1 1238182.C882_4113 1.52e-66 215.0 COG0543@1|root,COG0543@2|Bacteria,1R6QZ@1224|Proteobacteria,2V6M0@28211|Alphaproteobacteria,2JQRT@204441|Rhodospirillales 204441|Rhodospirillales CH Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B - - - - - - - - - - - - DHODB_Fe-S_bind,NAD_binding_1 k59_516226_1 1565129.JSFF01000028_gene695 4.93e-83 257.0 COG1680@1|root,COG1680@2|Bacteria,1MY01@1224|Proteobacteria,1RNUI@1236|Gammaproteobacteria,2Q8IR@267890|Shewanellaceae 1236|Gammaproteobacteria V PFAM beta-lactamase ampC - 3.5.2.6 ko:K01467 ko01501,ko02020,map01501,map02020 M00628 R06363 RC01499 ko00000,ko00001,ko00002,ko01000 - - - Beta-lactamase k59_685835_1 1231392.OCGS_0226 2.67e-76 247.0 COG2223@1|root,COG2223@2|Bacteria,1MWC7@1224|Proteobacteria,2TWNV@28211|Alphaproteobacteria 28211|Alphaproteobacteria P Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 k59_685839_1 1056820.KB900651_gene3158 1.06e-87 268.0 COG0673@1|root,COG0673@2|Bacteria,1MZIG@1224|Proteobacteria,1RYNC@1236|Gammaproteobacteria,2PMM6@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria S Oxidoreductase family, C-terminal alpha/beta domain gfo - 1.1.99.28 ko:K00118 - - - - ko00000,ko01000 - - - GFO_IDH_MocA,GFO_IDH_MocA_C k59_799732_1 1380600.AUYN01000001_gene2263 3.18e-43 146.0 COG2148@1|root,COG2148@2|Bacteria,4NNHR@976|Bacteroidetes,1I2JE@117743|Flavobacteriia 976|Bacteroidetes M Bacterial sugar transferase - - - - - - - - - - - - Bac_transf k59_799732_2 1046627.BZARG_131 1.46e-36 127.0 2CT98@1|root,32SSW@2|Bacteria,4NSGA@976|Bacteroidetes,1I40N@117743|Flavobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - DUF4258 k59_629469_1 1340493.JNIF01000003_gene1315 2e-113 338.0 COG0330@1|root,COG0330@2|Bacteria,3Y33E@57723|Acidobacteria 57723|Acidobacteria O PFAM Band 7 protein - - - - - - - - - - - - Band_7 k59_1646855_1 1384054.N790_05150 2.7e-65 215.0 COG3211@1|root,COG3211@2|Bacteria,1QY0R@1224|Proteobacteria,1S13A@1236|Gammaproteobacteria,1X5KR@135614|Xanthomonadales 135614|Xanthomonadales S Bacterial protein of unknown function (DUF839) - - - ko:K07093 - - - - ko00000 - - - DUF839,TAT_signal k59_1646855_2 521045.Kole_0098 1.36e-05 53.1 COG3437@1|root,COG3437@2|Bacteria,2GD4C@200918|Thermotogae 200918|Thermotogae T metal-dependent phosphohydrolase, HD sub domain - - - ko:K07814 - - - - ko00000,ko02022 - - - HD,Response_reg k59_1477497_1 59196.RICGR_1391 3.05e-09 56.2 COG0605@1|root,COG0605@2|Bacteria,1MVW2@1224|Proteobacteria,1RP7X@1236|Gammaproteobacteria,1JCK2@118969|Legionellales 118969|Legionellales C radicals which are normally produced within the cells and which are toxic to biological systems sodB - 1.15.1.1 ko:K04564 ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016 - - - ko00000,ko00001,ko01000 - - - Sod_Fe_C,Sod_Fe_N k59_1477497_2 290397.Adeh_0929 8.17e-26 109.0 COG0003@1|root,COG0003@2|Bacteria,1NA7C@1224|Proteobacteria,42V2J@68525|delta/epsilon subdivisions,2WS25@28221|Deltaproteobacteria,2YUZS@29|Myxococcales 28221|Deltaproteobacteria P Anion-transporting ATPase - - 3.6.3.16 ko:K01551 - - - - ko00000,ko01000,ko02000 3.A.19.1,3.A.21.1,3.A.4.1 - - ArsA_ATPase k59_1759473_1 876044.IMCC3088_709 3.79e-21 92.0 COG1012@1|root,COG1012@2|Bacteria,1MVGW@1224|Proteobacteria,1RN53@1236|Gammaproteobacteria,1J4US@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Belongs to the aldehyde dehydrogenase family calB - 1.2.1.68 ko:K00154 - - - - ko00000,ko01000 - - - Aldedh k59_572935_1 1121904.ARBP01000016_gene5190 4.5e-11 64.7 COG0469@1|root,COG0469@2|Bacteria,4NGQX@976|Bacteroidetes,47T9Y@768503|Cytophagia 976|Bacteroidetes G Pyruvate kinase, barrel domain - - 2.7.1.40 ko:K00873 ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230 M00001,M00002,M00049,M00050 R00200,R00430,R01138,R01858,R02320 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - PK k59_572935_2 1265313.HRUBRA_01464 3.97e-17 79.7 COG2010@1|root,COG2010@2|Bacteria,1RBTK@1224|Proteobacteria,1SMG9@1236|Gammaproteobacteria,1J913@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Cytochrome c - - - - - - - - - - - - Cytochrom_C k59_1251101_1 479434.Sthe_0985 4.34e-95 297.0 COG0277@1|root,COG0277@2|Bacteria,2G5TM@200795|Chloroflexi,27XF8@189775|Thermomicrobia 189775|Thermomicrobia C FAD linked oxidases, C-terminal domain - - 1.1.3.15 ko:K00104 ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130 - R00475 RC00042 ko00000,ko00001,ko01000 - - - FAD-oxidase_C,FAD_binding_4 k59_516242_1 161528.ED21_27993 1.2e-25 103.0 COG0649@1|root,COG0649@2|Bacteria,1MVIN@1224|Proteobacteria,2TQZ0@28211|Alphaproteobacteria,2K0QX@204457|Sphingomonadales 204457|Sphingomonadales C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoD - 1.6.5.3 ko:K00333 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_49kDa k59_516242_2 1096930.L284_15880 2.61e-65 200.0 COG4538@1|root,COG4538@2|Bacteria,1N60B@1224|Proteobacteria,2UEVR@28211|Alphaproteobacteria,2K5BA@204457|Sphingomonadales 204457|Sphingomonadales S SnoaL-like domain - - - - - - - - - - - - SnoaL_2 k59_460085_1 257310.BB2293 0.000167 43.5 COG1190@1|root,COG1190@2|Bacteria,1MX1V@1224|Proteobacteria,2VH1A@28216|Betaproteobacteria,3T2GE@506|Alcaligenaceae 28216|Betaproteobacteria J Belongs to the class-II aminoacyl-tRNA synthetase family lysS - 6.1.1.6 ko:K04567 ko00970,map00970 M00359,M00360 R03658 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_2,tRNA_anti-codon k59_460085_2 991905.SL003B_4266 1.41e-53 178.0 COG4122@1|root,COG4122@2|Bacteria,1MYYK@1224|Proteobacteria,2UADT@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Macrocin-O-methyltransferase (TylF) - - - - - - - - - - - - TylF k59_1137930_1 1198452.Jab_2c30280 1.24e-42 152.0 COG3826@1|root,COG3826@2|Bacteria,1MWVV@1224|Proteobacteria,2VHMX@28216|Betaproteobacteria,47322@75682|Oxalobacteraceae 28216|Betaproteobacteria S Oxygenase, catalysing oxidative methylation of damaged DNA - - - ko:K09990 - - - - ko00000 - - - Oxygenase-NA k59_121557_1 222534.KB893670_gene3882 2.72e-18 87.8 COG3507@1|root,COG3507@2|Bacteria 2|Bacteria G Belongs to the glycosyl hydrolase 43 family - - - ko:K20276 ko02024,map02024 - - - ko00000,ko00001 - - - Glyco_hyd_101C,Glyco_hydro_101,Glyco_hydro_43,NPCBM,NPCBM_assoc,RicinB_lectin_2 k59_121557_2 1192034.CAP_0656 1.28e-09 60.1 COG2308@1|root,COG2308@2|Bacteria,1MUAD@1224|Proteobacteria,42MA8@68525|delta/epsilon subdivisions,2WIXR@28221|Deltaproteobacteria,2YUA9@29|Myxococcales 28221|Deltaproteobacteria S Circularly permuted ATP-grasp type 2 - - - - - - - - - - - - CP_ATPgrasp_2 k59_629505_1 396595.TK90_0632 1.1e-32 119.0 COG1150@1|root,COG1150@2|Bacteria,1R7PH@1224|Proteobacteria,1SMDU@1236|Gammaproteobacteria 1236|Gammaproteobacteria C 4Fe-4S dicluster domain - - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 ko:K03390 ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200 M00356,M00357,M00563,M00567 R04540,R11928,R11931,R11943,R11944 RC00011 ko00000,ko00001,ko00002,ko01000 - - - Fer4_8 k59_629505_2 519989.ECTPHS_10836 1.54e-61 202.0 COG2048@1|root,COG2048@2|Bacteria,1R97P@1224|Proteobacteria,1SJXJ@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Cysteine-rich domain - - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 ko:K03389 ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200 M00356,M00357,M00563,M00567 R04540,R11928,R11931,R11943,R11944 RC00011 ko00000,ko00001,ko00002,ko01000 - - - CCG k59_460090_1 1459636.NTE_03071 2.25e-72 230.0 COG0861@1|root,arCOG09430@2157|Archaea 2157|Archaea P PFAM Integral membrane protein TerC - - - ko:K05794 - - - - ko00000 - - - TerC k59_856085_1 158500.BV97_00355 3.21e-43 150.0 COG1619@1|root,COG1619@2|Bacteria,1MWIY@1224|Proteobacteria,2U0U5@28211|Alphaproteobacteria,2K08M@204457|Sphingomonadales 204457|Sphingomonadales V proteins, homologs of microcin C7 resistance protein MccF - - 3.4.17.13 ko:K01297 - - - - ko00000,ko01000,ko01002,ko01011 - - - Peptidase_S66 k59_856085_2 555793.WSK_1342 1.42e-56 188.0 COG0773@1|root,COG0773@2|Bacteria,1MVCG@1224|Proteobacteria,2TTDN@28211|Alphaproteobacteria,2K0S4@204457|Sphingomonadales 204457|Sphingomonadales M UDP-N-acetylmuramate-alanine ligase - - 6.3.2.8 ko:K01924 ko00471,ko00550,ko01100,map00471,map00550,map01100 - R03193 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_1533748_1 246200.SPO0590 1.08e-17 84.7 COG1609@1|root,COG1609@2|Bacteria,1MVUR@1224|Proteobacteria,2TUPD@28211|Alphaproteobacteria,4NAVD@97050|Ruegeria 28211|Alphaproteobacteria K Transcriptional regulator, LacI family - - - ko:K02529,ko:K06145 - - - - ko00000,ko03000 - - - LacI,Peripla_BP_3 k59_1533748_2 1307761.L21SP2_2526 5.28e-05 45.4 COG1070@1|root,COG1070@2|Bacteria,2J5M1@203691|Spirochaetes 203691|Spirochaetes G PFAM FGGY family of carbohydrate kinases, N-terminal domain xylB - 2.7.1.17 ko:K00854 ko00040,ko01100,map00040,map01100 M00014 R01639 RC00002,RC00538 ko00000,ko00001,ko00002,ko01000 - - - FGGY_C,FGGY_N k59_742765_1 1121921.KB898710_gene455 5.21e-31 119.0 COG2375@1|root,COG2375@2|Bacteria,1R4TD@1224|Proteobacteria,1RY01@1236|Gammaproteobacteria 1236|Gammaproteobacteria P Siderophore-interacting protein - - - - - - - - - - - - FAD_binding_9,SIP k59_742765_2 1206744.BAGL01000055_gene1534 4.52e-32 120.0 COG1695@1|root,COG1695@2|Bacteria,2GMKD@201174|Actinobacteria,4G1XT@85025|Nocardiaceae 201174|Actinobacteria K Transcriptional regulator PadR-like family - - - - - - - - - - - - PadR k59_516267_1 247634.GPB2148_1955 2.68e-39 143.0 COG4638@1|root,COG4638@2|Bacteria,1NTEB@1224|Proteobacteria,1SBPF@1236|Gammaproteobacteria 1236|Gammaproteobacteria P Ring hydroxylating alpha subunit (catalytic domain) - - - - - - - - - - - - Rieske,Ring_hydroxyl_A k59_516267_2 1215092.PA6_010_00060 5e-05 45.1 COG0625@1|root,COG0625@2|Bacteria,1P71B@1224|Proteobacteria,1S29M@1236|Gammaproteobacteria,1YDJI@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria O Glutathione S-transferase, C-terminal domain - - - - - - - - - - - - GST_C_2,GST_N_3 k59_291266_1 187272.Mlg_1890 3.83e-73 241.0 COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MU0R@1224|Proteobacteria,1RP3T@1236|Gammaproteobacteria,1WXGJ@135613|Chromatiales 135613|Chromatiales G Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate - - 2.7.9.2 ko:K01007 ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200 M00173,M00374 R00199 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - PEP-utilizers,PEP-utilizers_C,PPDK_N k59_1477537_2 1121406.JAEX01000002_gene1174 5.86e-50 169.0 COG0438@1|root,COG0438@2|Bacteria,1MUB7@1224|Proteobacteria,42N14@68525|delta/epsilon subdivisions,2WIKT@28221|Deltaproteobacteria,2MEQX@213115|Desulfovibrionales 28221|Deltaproteobacteria M Glycosyltransferase Family 4 - - - - - - - - - - - - Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1 k59_516269_1 1283300.ATXB01000001_gene1161 5.62e-134 387.0 COG2878@1|root,COG2878@2|Bacteria,1RE44@1224|Proteobacteria,1S5MU@1236|Gammaproteobacteria,1XF1N@135618|Methylococcales 135618|Methylococcales C Part of a membrane complex involved in electron transport - - - ko:K03616 - - - - ko00000 - - - FeS,Fer4_21 k59_516269_2 1027273.GZ77_25365 1.28e-30 119.0 COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1145@1|root,COG1146@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1145@2|Bacteria,COG1146@2|Bacteria,1MVM0@1224|Proteobacteria,1RNNX@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin - - 1.2.7.1 ko:K03737 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00173,M00307 R01196,R10866 RC00004,RC02742 br01601,ko00000,ko00001,ko00002,ko01000 - - - Fer4,Fer4_13,Fer4_6,PFOR_II,POR,POR_N,TPP_enzyme_C k59_1702824_1 1121939.L861_18215 4.97e-20 94.4 COG1538@1|root,COG2885@1|root,COG1538@2|Bacteria,COG2885@2|Bacteria,1MYX2@1224|Proteobacteria,1RNX1@1236|Gammaproteobacteria,1XIGH@135619|Oceanospirillales 135619|Oceanospirillales MU type I secretion outer membrane protein, TolC - - - ko:K12543 - M00330 - - ko00000,ko00002,ko02000,ko02044 1.B.17,3.A.1.109.4 - - OEP,OmpA,SPOR k59_1590609_1 1120983.KB894571_gene2712 2.79e-13 72.8 COG1296@1|root,COG1296@2|Bacteria,1QFIN@1224|Proteobacteria,2U0SX@28211|Alphaproteobacteria,1JP0E@119043|Rhodobiaceae 28211|Alphaproteobacteria E AzlC protein MA20_36175 - - - - - - - - - - - AzlC k59_292267_1 436308.Nmar_1773 1.84e-137 404.0 COG0668@1|root,arCOG01568@2157|Archaea,41SYX@651137|Thaumarchaeota 651137|Thaumarchaeota M Mechanosensitive ion channel - - - ko:K05802 - - - - ko00000,ko02000 1.A.23.1.1 - - MS_channel k59_1365262_2 436308.Nmar_0068 3.75e-22 90.9 COG0518@1|root,arCOG00087@2157|Archaea,41SQR@651137|Thaumarchaeota 651137|Thaumarchaeota F glutamine amidotransferase - - 6.3.5.2 ko:K01951 ko00230,ko00983,ko01100,map00230,map00983,map01100 M00050 R01230,R01231,R08244 RC00010,RC00204 ko00000,ko00001,ko00002,ko01000,ko01002 - - - GATase k59_461092_1 1121015.N789_01370 3.55e-35 134.0 COG1187@1|root,COG1187@2|Bacteria,1MUCE@1224|Proteobacteria,1RQU0@1236|Gammaproteobacteria,1X2YH@135614|Xanthomonadales 135614|Xanthomonadales J Belongs to the pseudouridine synthase RsuA family rluB GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360 5.4.99.22 ko:K06178 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2,S4 k59_743740_1 1205680.CAKO01000040_gene504 1.21e-29 107.0 COG0537@1|root,COG0537@2|Bacteria,1RDCJ@1224|Proteobacteria,2U956@28211|Alphaproteobacteria,2JSVP@204441|Rhodospirillales 204441|Rhodospirillales FG COG0537 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases - - - - - - - - - - - - HIT k59_743740_2 1122137.AQXF01000001_gene3350 1.11e-77 243.0 COG1220@1|root,COG1220@2|Bacteria,1MVK9@1224|Proteobacteria,2TRXC@28211|Alphaproteobacteria 28211|Alphaproteobacteria O this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis hslU - - ko:K03667 - - - - ko00000,ko03110 - - - AAA_2,ClpB_D2-small k59_573957_1 351746.Pput_3339 5.8e-50 180.0 COG4251@1|root,COG4251@2|Bacteria,1NSQ1@1224|Proteobacteria,1RYEF@1236|Gammaproteobacteria,1YV2N@136845|Pseudomonas putida group 1236|Gammaproteobacteria T Histidine kinase - - - - - - - - - - - - GAF,HATPase_c,HisKA,PAS_2,PHY k59_1534737_1 338963.Pcar_1256 2.26e-66 213.0 COG0673@1|root,COG0673@2|Bacteria,1MV7C@1224|Proteobacteria,42NV0@68525|delta/epsilon subdivisions,2WK1Y@28221|Deltaproteobacteria,43T3I@69541|Desulfuromonadales 28221|Deltaproteobacteria S Oxidoreductase family, NAD-binding Rossmann fold gnnA - - ko:K09949 - - - - ko00000 - - iAF987.Gmet_2352 GFO_IDH_MocA,GFO_IDH_MocA_C k59_1365266_1 745776.DGo_CA0909 2.73e-89 272.0 COG0667@1|root,COG0667@2|Bacteria 2|Bacteria C Aldo Keto reductase - - - - - - - - - - - - Aldo_ket_red k59_404608_1 405948.SACE_4929 1.88e-50 171.0 COG1960@1|root,COG1960@2|Bacteria,2HJFH@201174|Actinobacteria,4E0MB@85010|Pseudonocardiales 201174|Actinobacteria I Acyl-CoA dehydrogenase, C-terminal domain - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_2,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_1308749_1 572544.Ilyop_1275 4.1e-11 68.9 COG0240@1|root,COG0240@2|Bacteria,378MQ@32066|Fusobacteria 32066|Fusobacteria I Glycerol-3-phosphate dehydrogenase gpsA - 1.1.1.94 ko:K00057 ko00564,ko01110,map00564,map01110 - R00842,R00844 RC00029 ko00000,ko00001,ko01000 - - - NAD_Gly3P_dh_C,NAD_Gly3P_dh_N k59_573962_1 314264.ROS217_22957 1.34e-10 61.6 COG1233@1|root,COG1233@2|Bacteria,1MV2R@1224|Proteobacteria,2TSR0@28211|Alphaproteobacteria,46NN6@74030|Roseovarius 28211|Alphaproteobacteria Q And related proteins - - - - - - - - - - - - Amino_oxidase,NAD_binding_8 k59_573962_2 1122135.KB893134_gene3132 2.59e-34 131.0 COG1233@1|root,COG1233@2|Bacteria,1MV2R@1224|Proteobacteria,2TSR0@28211|Alphaproteobacteria 28211|Alphaproteobacteria Q Phytoene dehydrogenase - - - - - - - - - - - - Amino_oxidase,NAD_binding_8 k59_1252215_1 1266925.JHVX01000004_gene1207 2.84e-77 257.0 COG0439@1|root,COG1984@1|root,COG2049@1|root,COG0439@2|Bacteria,COG1984@2|Bacteria,COG2049@2|Bacteria,1MU4H@1224|Proteobacteria,2WGI2@28216|Betaproteobacteria,3729H@32003|Nitrosomonadales 28216|Betaproteobacteria EI Biotin lipoyl attachment uca - 6.3.4.6 ko:K01941 ko00220,ko00791,ko01100,map00220,map00791,map01100 - R00774 RC00378 ko00000,ko00001,ko01000 - - - Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2,CT_A_B,CT_C_D k59_913201_1 983545.Glaag_2757 3.02e-77 239.0 COG0294@1|root,COG0294@2|Bacteria,1MUIR@1224|Proteobacteria,1RM8G@1236|Gammaproteobacteria,4642K@72275|Alteromonadaceae 1236|Gammaproteobacteria H Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives folP GO:0003674,GO:0003824,GO:0004156,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009396,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042221,GO:0042364,GO:0042398,GO:0042493,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046653,GO:0046654,GO:0046655,GO:0046656,GO:0050896,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.15 ko:K00796 ko00790,ko01100,map00790,map01100 M00126,M00841 R03066,R03067 RC00121,RC00842 ko00000,ko00001,ko00002,ko01000 - - iECO103_1326.ECO103_3924,iPC815.YPO3501 Pterin_bind k59_1655968_1 886293.Sinac_1361 1.85e-101 323.0 COG1009@1|root,COG1009@2|Bacteria,2IX10@203682|Planctomycetes 203682|Planctomycetes CP NADH-Ubiquinone oxidoreductase (complex I), chain 5 - - 1.6.5.3 ko:K00341 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Proton_antipo_M,Proton_antipo_N k59_412373_1 688245.CtCNB1_2970 1.88e-40 142.0 COG1595@1|root,COG1595@2|Bacteria,1N38X@1224|Proteobacteria,2VU1J@28216|Betaproteobacteria,4AFBS@80864|Comamonadaceae 28216|Betaproteobacteria K TIGRFAM RNA polymerase sigma factor, sigma-70 family - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4,Sigma70_r4_2 k59_412373_2 399795.CtesDRAFT_PD1636 1.74e-05 47.4 2A20V@1|root,30QAU@2|Bacteria,1RDQH@1224|Proteobacteria,2VQZV@28216|Betaproteobacteria,4ADSI@80864|Comamonadaceae 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_1203601_8 498211.CJA_0728 9.12e-56 181.0 COG0629@1|root,COG0629@2|Bacteria,1RCWT@1224|Proteobacteria,1S3WP@1236|Gammaproteobacteria,1FH39@10|Cellvibrio 1236|Gammaproteobacteria L Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism ssb - - ko:K03111 ko03030,ko03430,ko03440,map03030,map03430,map03440 - - - ko00000,ko00001,ko03029,ko03032,ko03400 - - - SSB k59_1034976_1 391625.PPSIR1_30075 3.28e-28 111.0 COG1028@1|root,COG1028@2|Bacteria,1MU2T@1224|Proteobacteria,43A1N@68525|delta/epsilon subdivisions,2X25S@28221|Deltaproteobacteria,2YYJ4@29|Myxococcales 28221|Deltaproteobacteria IQ NAD dependent epimerase dehydratase family protein - - 1.1.1.100 ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 k59_1034976_2 1122180.Lokhon_01436 3e-47 167.0 COG0628@1|root,COG0628@2|Bacteria,1MXXU@1224|Proteobacteria,2TVPN@28211|Alphaproteobacteria,2P9QW@245186|Loktanella 28211|Alphaproteobacteria S AI-2E family transporter - - - - - - - - - - - - AI-2E_transport k59_300185_1 392499.Swit_4014 1.55e-40 148.0 COG3524@1|root,COG3524@2|Bacteria,1R3ZY@1224|Proteobacteria,2U0I2@28211|Alphaproteobacteria,2K2BB@204457|Sphingomonadales 204457|Sphingomonadales M COG3524 Capsule polysaccharide export protein - - - ko:K10107 ko02010,map02010 M00249 - - ko00000,ko00001,ko00002,ko02000 3.A.1.101 - - Wzz k59_1542606_1 568706.BN118_0974 2.91e-104 324.0 COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,2VKIW@28216|Betaproteobacteria,3T1CY@506|Alcaligenaceae 28216|Betaproteobacteria I Acyl-CoA dehydrogenases fadE - - ko:K06445 ko00071,ko01100,ko01212,map00071,map01100,map01212 M00087 R01175,R01279,R03777,R03857,R03990,R04751,R04754 RC00052,RC00076 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N,DUF1974 k59_17168_2 105420.BBPO01000059_gene3249 3.93e-16 76.6 COG5637@1|root,COG5637@2|Bacteria,2HQQX@201174|Actinobacteria,2NMEQ@228398|Streptacidiphilus 201174|Actinobacteria S Polyketide cyclase / dehydrase and lipid transport - - - - - - - - - - - - Polyketide_cyc2 k59_300189_1 247633.GP2143_09510 1.83e-87 275.0 COG5265@1|root,COG5265@2|Bacteria,1NSKS@1224|Proteobacteria,1T1W9@1236|Gammaproteobacteria,1J5MS@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria V COG5265 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components atmA - - ko:K06147 - - - - ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran k59_1034989_1 436308.Nmar_1358 2.08e-56 192.0 COG0491@1|root,arCOG00507@2157|Archaea 2157|Archaea S Metallo-beta-lactamase superfamily - - - - - - - - - - - - Lactamase_B k59_1259622_1 1266909.AUAG01000001_gene1482 4.45e-58 194.0 2DG8R@1|root,2ZUYV@2|Bacteria,1RG4Q@1224|Proteobacteria,1SA59@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Sulfotransferase domain - - - - - - - - - - - - Sulfotransfer_1 k59_1542611_1 595537.Varpa_5066 1.9e-97 305.0 COG0318@1|root,COG0318@2|Bacteria,1MUQZ@1224|Proteobacteria,2VIB6@28216|Betaproteobacteria,4ACZX@80864|Comamonadaceae 28216|Betaproteobacteria IQ PFAM AMP-dependent synthetase and ligase fcs - 6.2.1.34 ko:K12508 - - - - ko00000,ko01000 - - - AMP-binding k59_1768359_1 765913.ThidrDRAFT_3811 5.72e-85 260.0 COG0136@1|root,COG0136@2|Bacteria,1MUHG@1224|Proteobacteria,1RMN3@1236|Gammaproteobacteria,1WW1E@135613|Chromatiales 135613|Chromatiales E Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate asd - 1.2.1.11 ko:K00133 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00017,M00018,M00033,M00525,M00526,M00527 R02291 RC00684 ko00000,ko00001,ko00002,ko01000 - - - Semialdhyde_dh,Semialdhyde_dhC k59_524815_1 1163617.SCD_n01900 6.33e-64 213.0 COG0323@1|root,COG0323@2|Bacteria,1MV61@1224|Proteobacteria,2VIBW@28216|Betaproteobacteria 28216|Betaproteobacteria L This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex mutL - - ko:K03572 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - DNA_mis_repair,HATPase_c_3,MutL_C k59_865328_1 436308.Nmar_0701 5.43e-22 94.7 COG0365@1|root,arCOG04201@2157|Archaea 2157|Archaea I COG0365 Acyl-coenzyme A synthetases AMP-(fatty) acid ligases acsA - 6.2.1.1 ko:K01895 ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200 M00357 R00235,R00236,R00316,R00926,R01354 RC00004,RC00012,RC00043,RC00070,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000,ko01004 - - - ACAS_N,AMP-binding,AMP-binding_C k59_865328_2 1229909.NSED_03635 6.12e-70 216.0 arCOG05183@1|root,arCOG05183@2157|Archaea 2157|Archaea T PAS domain - - - - - - - - - - - - HATPase_c,HisKA_2,PAS,PAS_4,PAS_9,Response_reg k59_1486693_1 1051985.l11_05270 2.12e-25 108.0 COG0845@1|root,COG0845@2|Bacteria,1MU78@1224|Proteobacteria,2VINC@28216|Betaproteobacteria,2KPHI@206351|Neisseriales 206351|Neisseriales M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family acrA - - ko:K03585 ko01501,ko01503,map01501,map01503 M00646,M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000,ko03036 2.A.6.2,8.A.1.6 - - HlyD_D23 k59_865341_1 335283.Neut_2457 1.01e-94 303.0 COG1048@1|root,COG1048@2|Bacteria,1MU9T@1224|Proteobacteria,2VKDZ@28216|Betaproteobacteria,371SX@32003|Nitrosomonadales 28216|Betaproteobacteria C Aconitase C-terminal domain acnA - 4.2.1.3 ko:K01681 ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00173,M00740 R01324,R01325,R01900 RC00497,RC00498,RC00618 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase,Aconitase_C k59_1656028_1 95619.PM1_0215945 1.3e-54 191.0 COG0342@1|root,COG0342@2|Bacteria,1MV5U@1224|Proteobacteria,1RMIQ@1236|Gammaproteobacteria 1236|Gammaproteobacteria U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA secD GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944 - ko:K03072 ko03060,ko03070,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 2.A.6.4,3.A.5.2,3.A.5.7 - - SecD-TM1,SecD_SecF,Sec_GG k59_694954_1 40483.S8F826 0.000303 47.0 COG2272@1|root,KOG4389@2759|Eukaryota,39UVY@33154|Opisthokonta,3NUEU@4751|Fungi,3V0BA@5204|Basidiomycota,228PS@155619|Agaricomycetes,3H1NF@355688|Agaricomycetes incertae sedis 4751|Fungi T Alpha beta-hydrolase - - - - - - - - - - - - COesterase k59_581967_2 65497.JODV01000002_gene4340 6.53e-54 187.0 COG2141@1|root,COG2141@2|Bacteria,2GM94@201174|Actinobacteria,4DXUF@85010|Pseudonocardiales 201174|Actinobacteria C Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone fgd GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016491,GO:0016614,GO:0019725,GO:0030312,GO:0031406,GO:0036094,GO:0042592,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043177,GO:0044424,GO:0044444,GO:0044464,GO:0045454,GO:0046983,GO:0048037,GO:0050662,GO:0050789,GO:0050794,GO:0055114,GO:0065007,GO:0065008,GO:0070967,GO:0071944,GO:0097159,GO:0097367,GO:1901363 1.1.98.2 ko:K15510 - - - - ko00000,ko01000 - - - Bac_luciferase k59_976544_1 1122137.AQXF01000004_gene1826 2.59e-126 377.0 COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,2TS19@28211|Alphaproteobacteria 28211|Alphaproteobacteria F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides nrdA - 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - RNR_N,Ribonuc_red_lgC,Ribonuc_red_lgN k59_1316799_1 1144319.PMI16_02016 4.17e-56 183.0 COG1309@1|root,COG1309@2|Bacteria,1RE2I@1224|Proteobacteria,2VK5I@28216|Betaproteobacteria 28216|Betaproteobacteria K to Deinococcus radiodurans transcriptional regulator, tetr family dr2376 SWALL Q9RRV9 (EMBL AE002068) (197 aa) fasta scores E() - - - - - - - - - - - - TetR_N k59_468856_1 1207063.P24_18194 4.47e-18 82.0 COG0526@1|root,COG0526@2|Bacteria,1MZ5J@1224|Proteobacteria,2TR0C@28211|Alphaproteobacteria,2JT90@204441|Rhodospirillales 204441|Rhodospirillales CO COG0526 Thiol-disulfide isomerase and thioredoxins - - - - - - - - - - - - Redoxin k59_694966_1 512565.AMIS_48360 1.59e-28 119.0 COG2124@1|root,COG2124@2|Bacteria,2GJ8V@201174|Actinobacteria,4DD1T@85008|Micromonosporales 201174|Actinobacteria Q Cytochrome P450 - - - - - - - - - - - - p450 k59_74411_1 1123388.AQWU01000070_gene112 6.45e-23 105.0 COG2202@1|root,COG3437@1|root,COG3829@1|root,COG2202@2|Bacteria,COG3437@2|Bacteria,COG3829@2|Bacteria,1WJ3D@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus T PFAM HD domain - - - - - - - - - - - - GAF,GAF_2,HD,HD_5,PAS,PAS_3,PAS_4,PAS_9 k59_1598816_1 504487.JCM19302_3590 6.54e-11 64.3 COG2271@1|root,COG2271@2|Bacteria,4NGCR@976|Bacteroidetes,1HWZ4@117743|Flavobacteriia 976|Bacteroidetes G Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 k59_1598816_2 1230341.MJ3_07923 0.000116 47.4 COG0646@1|root,COG0646@2|Bacteria,1TPYV@1239|Firmicutes,4HAB5@91061|Bacilli 91061|Bacilli E catalyzes the formation of 5,10-methylenetetrahydrofolate from 5-methyltetrahydrofolate and S-adenosyl-L-homocysteine and methionine from S-adenosyl-L-methionine and L-homocysteine yitJ - 1.5.1.20,2.1.1.10,2.1.1.5 ko:K00297,ko:K00544,ko:K00547 ko00260,ko00270,ko00670,ko00720,ko01100,ko01110,ko01120,ko01200,ko01523,map00260,map00270,map00670,map00720,map01100,map01110,map01120,map01200,map01523 M00377 R00650,R01224,R02821,R07168 RC00003,RC00035,RC00081,RC00496 ko00000,ko00001,ko00002,ko01000 - - - MTHFR,S-methyl_trans k59_412440_1 1160137.KB907309_gene5718 7.06e-28 113.0 COG2084@1|root,COG2084@2|Bacteria,2GNI7@201174|Actinobacteria,4FVG5@85025|Nocardiaceae 201174|Actinobacteria I NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase - - 1.1.1.31,1.1.1.60 ko:K00020,ko:K00042 ko00280,ko00630,ko01100,map00280,map00630,map01100 - R01745,R01747,R05066 RC00099 ko00000,ko00001,ko01000 - - - NAD_binding_11,NAD_binding_2 k59_1542663_1 1249627.D779_3240 5.06e-66 210.0 COG0190@1|root,COG0190@2|Bacteria,1MWU4@1224|Proteobacteria,1RNSW@1236|Gammaproteobacteria,1WWX4@135613|Chromatiales 135613|Chromatiales F Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate folD - 1.5.1.5,3.5.4.9 ko:K01491 ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200 M00140,M00377 R01220,R01655 RC00202,RC00578 ko00000,ko00001,ko00002,ko01000 - - - THF_DHG_CYH,THF_DHG_CYH_C k59_1316813_1 944480.ATUV01000001_gene1329 1.15e-05 52.0 COG0457@1|root,COG0457@2|Bacteria,1MZCR@1224|Proteobacteria,42R7I@68525|delta/epsilon subdivisions,2WMT6@28221|Deltaproteobacteria,2M7IU@213113|Desulfurellales 28221|Deltaproteobacteria S Tetratricopeptide repeat pilG - - - - - - - - - - - - k59_1316813_2 1306174.JODP01000016_gene7152 7.95e-18 82.0 COG1131@1|root,COG1131@2|Bacteria,2GKI7@201174|Actinobacteria 201174|Actinobacteria V ABC transporter - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran,DUF4162 k59_1542675_1 941449.dsx2_0017 2.12e-18 90.9 COG5000@1|root,COG5000@2|Bacteria,1NU7E@1224|Proteobacteria,42YTZ@68525|delta/epsilon subdivisions,2WU37@28221|Deltaproteobacteria,2MHFF@213115|Desulfovibrionales 28221|Deltaproteobacteria T PFAM ATP-binding region ATPase domain protein, histidine kinase A domain protein - - - - - - - - - - - - HATPase_c,HisKA k59_865382_1 287.DR97_303 1.53e-55 187.0 COG0508@1|root,COG0508@2|Bacteria,1MUJD@1224|Proteobacteria,1RME0@1236|Gammaproteobacteria,1YF4F@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria C The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) sucB GO:0003674,GO:0003824,GO:0004149,GO:0005488,GO:0005504,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0008289,GO:0009060,GO:0009987,GO:0015980,GO:0016417,GO:0016740,GO:0016746,GO:0016747,GO:0016748,GO:0016751,GO:0016999,GO:0017144,GO:0019752,GO:0031405,GO:0031406,GO:0032991,GO:0033293,GO:0036094,GO:0043167,GO:0043168,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045239,GO:0045240,GO:0045252,GO:0045333,GO:0048037,GO:0050662,GO:0055114,GO:0071704,GO:0072350,GO:0097159,GO:0140096,GO:1901363,GO:1901681,GO:1902494,GO:1990204,GO:1990234 2.3.1.61 ko:K00658 ko00020,ko00310,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00032 R02570,R02571,R08549 RC00004,RC02727,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - iAPECO1_1312.APECO1_1352,iECED1_1282.ECED1_0696,iECOK1_1307.ECOK1_0726,iECS88_1305.ECS88_0752,iLF82_1304.LF82_2196,iNRG857_1313.NRG857_03235,iUMN146_1321.UM146_13990,iUTI89_1310.UTI89_C0722 2-oxoacid_dh,Biotin_lipoyl,E3_binding k59_1656092_1 635013.TherJR_1368 8.64e-62 207.0 COG0442@1|root,COG0442@2|Bacteria,1TRBV@1239|Firmicutes,249PY@186801|Clostridia,260WS@186807|Peptococcaceae 186801|Clostridia J Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS proS - 6.1.1.15 ko:K01881 ko00970,map00970 M00359,M00360 R03661 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,tRNA-synt_2b,tRNA_edit k59_74452_1 1183438.GKIL_2326 7.76e-84 261.0 COG0399@1|root,COG0399@2|Bacteria,1G0IM@1117|Cyanobacteria 1117|Cyanobacteria E Belongs to the DegT DnrJ EryC1 family - - - - - - - - - - - - DegT_DnrJ_EryC1 k59_1712643_1 331869.BAL199_18781 1.22e-89 266.0 COG0723@1|root,COG0723@2|Bacteria,1RAA2@1224|Proteobacteria,2TTT2@28211|Alphaproteobacteria,4BQ3Z@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria C Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis petA - 1.10.2.2 ko:K00411 ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016 M00151,M00152 - - ko00000,ko00001,ko00002,ko01000 - - - Rieske,UCR_Fe-S_N k59_357539_1 330214.NIDE0304 7.44e-77 243.0 COG5000@1|root,COG5002@1|root,COG5000@2|Bacteria,COG5002@2|Bacteria,3J11K@40117|Nitrospirae 40117|Nitrospirae T HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - - - - - - - - - - - HATPase_c,HisKA k59_752195_1 1197477.IA57_00010 2.32e-56 192.0 COG2304@1|root,COG2304@2|Bacteria,4PKD0@976|Bacteroidetes,1HWKJ@117743|Flavobacteriia 976|Bacteroidetes U Large extracellular alpha-helical protein - - - - - - - - - - - - CHU_C,HYR,LRR_adjacent k59_752195_2 1347342.BN863_23390 1.12e-26 105.0 COG3064@1|root,COG3064@2|Bacteria,4NEVD@976|Bacteroidetes,1HWKC@117743|Flavobacteriia 976|Bacteroidetes M membrane - - - - - - - - - - - - PorP_SprF k59_809279_1 1122137.AQXF01000004_gene1727 3.56e-202 570.0 COG0006@1|root,COG0006@2|Bacteria,1MUZS@1224|Proteobacteria,2TRQ5@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Belongs to the peptidase M24B family - - 3.4.13.9 ko:K01271 - - - - ko00000,ko01000,ko01002 - - - Creatinase_N,Peptidase_M24 k59_977367_1 1068980.ARVW01000001_gene523 2.13e-09 59.3 COG0529@1|root,COG2895@1|root,COG0529@2|Bacteria,COG2895@2|Bacteria,2GJDX@201174|Actinobacteria,4E0GC@85010|Pseudonocardiales 201174|Actinobacteria P Catalyzes the synthesis of activated sulfate cysN GO:0000103,GO:0003674,GO:0003824,GO:0004020,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006790,GO:0006793,GO:0006796,GO:0006950,GO:0006979,GO:0007154,GO:0008150,GO:0008152,GO:0009267,GO:0009336,GO:0009605,GO:0009987,GO:0009991,GO:0010134,GO:0010438,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019419,GO:0031667,GO:0031668,GO:0031669,GO:0032991,GO:0033554,GO:0034599,GO:0040007,GO:0042221,GO:0042594,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716,GO:0055114,GO:0061695,GO:0070887,GO:0071496,GO:0071944,GO:1902494,GO:1902503,GO:1990234 2.7.1.25,2.7.7.4 ko:K00955,ko:K00956 ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130 M00176,M00596 R00509,R00529,R04928,R04929 RC00002,RC00078,RC02809,RC02889 ko00000,ko00001,ko00002,ko01000 - - - APS_kinase,GTP_EFTU k59_1147575_1 882083.SacmaDRAFT_5488 1.45e-21 98.6 COG3391@1|root,COG3794@1|root,COG3391@2|Bacteria,COG3794@2|Bacteria,2GM0K@201174|Actinobacteria,4DZ7Y@85010|Pseudonocardiales 201174|Actinobacteria C amine dehydrogenase activity - - - - - - - - - - - - Cupredoxin_1 k59_809281_1 448385.sce1542 9.85e-09 64.7 2DQ41@1|root,334MP@2|Bacteria,1QWJG@1224|Proteobacteria,43CUB@68525|delta/epsilon subdivisions,2X81Y@28221|Deltaproteobacteria,2Z1U1@29|Myxococcales 1224|Proteobacteria S Kazal type serine protease inhibitors - - - - - - - - - - - - Kazal_1 k59_695706_1 316407.1742104 3.47e-135 388.0 COG1123@1|root,COG4172@2|Bacteria,1MU09@1224|Proteobacteria,1RMEI@1236|Gammaproteobacteria,3XNRN@561|Escherichia 1236|Gammaproteobacteria P Part of a putrescine export transport system, does not play a role in resistance to antimicrobial peptides. Stimulates K( )-uptake proteins TrkG and TrkH to import K( ), may act via ATP-binding rather than ATP hydrolysis sapD GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0006857,GO:0008144,GO:0008150,GO:0008324,GO:0008519,GO:0009987,GO:0015075,GO:0015101,GO:0015203,GO:0015399,GO:0015405,GO:0015489,GO:0015672,GO:0015695,GO:0015696,GO:0015833,GO:0015846,GO:0015847,GO:0015893,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0030001,GO:0030554,GO:0031224,GO:0031226,GO:0032553,GO:0032555,GO:0032559,GO:0034220,GO:0035639,GO:0035672,GO:0036094,GO:0042221,GO:0042493,GO:0042623,GO:0042626,GO:0042884,GO:0042886,GO:0042891,GO:0043167,GO:0043168,GO:0043492,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071804,GO:0071805,GO:0071944,GO:0072488,GO:0097159,GO:0097367,GO:0098655,GO:0098660,GO:0098662,GO:1901265,GO:1901363,GO:1902047 - ko:K02031,ko:K02032,ko:K13892,ko:K13896,ko:K19229,ko:K19230 ko01503,ko02010,ko02024,map01503,map02010,map02024 M00239,M00348,M00349,M00739 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5,3.A.1.5.11,3.A.1.5.21,3.A.1.5.24,3.A.1.5.5 - iSbBS512_1146.SbBS512_E2519,iYL1228.KPN_01288 ABC_tran,oligo_HPY k59_1429988_1 436308.Nmar_0599 1.51e-08 55.1 COG4046@1|root,arCOG04181@2157|Archaea,41S8T@651137|Thaumarchaeota 651137|Thaumarchaeota S Protein of unknown function (DUF1512) - - - - - - - - - - - - DUF1512 k59_1656951_1 1122137.AQXF01000002_gene171 9.76e-150 425.0 COG0320@1|root,COG0320@2|Bacteria,1MVRD@1224|Proteobacteria,2TRP3@28211|Alphaproteobacteria 28211|Alphaproteobacteria H Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives lipA GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009106,GO:0009107,GO:0009108,GO:0009249,GO:0009987,GO:0010467,GO:0016053,GO:0016740,GO:0016782,GO:0016783,GO:0016992,GO:0018065,GO:0018130,GO:0018193,GO:0018205,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0051604,GO:0070283,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901576 2.8.1.8 ko:K03644 ko00785,ko01100,map00785,map01100 - R07767,R07768 RC01978 ko00000,ko00001,ko01000 - - - LIAS_N,Radical_SAM k59_1429992_1 1123393.KB891316_gene1932 1.52e-77 247.0 COG0773@1|root,COG0773@2|Bacteria,1MUC5@1224|Proteobacteria,2VIX5@28216|Betaproteobacteria,1KSMD@119069|Hydrogenophilales 119069|Hydrogenophilales M Mur ligase family, catalytic domain - - 6.3.2.45 ko:K02558 - - - - ko00000,ko01000 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_1429993_1 1122214.AQWH01000004_gene1104 2.36e-30 121.0 COG4246@1|root,COG4246@2|Bacteria,1N7Y1@1224|Proteobacteria,2TTZW@28211|Alphaproteobacteria,2PJR0@255475|Aurantimonadaceae 28211|Alphaproteobacteria S Esterase-like activity of phytase - - - - - - - - - - - - Phytase-like k59_977379_1 644282.Deba_2836 3.25e-40 151.0 COG1033@1|root,COG1033@2|Bacteria,1MUE1@1224|Proteobacteria,42ME2@68525|delta/epsilon subdivisions,2WJRI@28221|Deltaproteobacteria 28221|Deltaproteobacteria T PFAM MMPL family - - - ko:K07003 - - - - ko00000 - - - MMPL k59_639457_1 1304872.JAGC01000003_gene2364 6.62e-39 146.0 28I8B@1|root,2Z8B5@2|Bacteria,1MUNM@1224|Proteobacteria,42NZH@68525|delta/epsilon subdivisions,2WKHB@28221|Deltaproteobacteria,2M9ZJ@213115|Desulfovibrionales 28221|Deltaproteobacteria P Cytochrome c bacterial - - - - - - - - - - - - Cytochrome_cB k59_469779_1 1283300.ATXB01000001_gene2059 8.97e-77 243.0 COG0460@1|root,COG0460@2|Bacteria,1MUDC@1224|Proteobacteria,1RPEU@1236|Gammaproteobacteria,1XEDH@135618|Methylococcales 135618|Methylococcales E homoserine dehydrogenase hom - 1.1.1.3 ko:K00003 ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230 M00017,M00018 R01773,R01775 RC00087 ko00000,ko00001,ko00002,ko01000 - - - ACT,Homoserine_dh,NAD_binding_3 k59_75369_1 261292.Nit79A3_3289 6.15e-18 80.5 COG1595@1|root,COG1595@2|Bacteria,1MVPD@1224|Proteobacteria,2WA1D@28216|Betaproteobacteria,3741J@32003|Nitrosomonadales 28216|Betaproteobacteria K PFAM RNA polymerase sigma factor 70, region 4 type 2 - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r4_2 k59_639461_1 746697.Aeqsu_2955 1.06e-107 335.0 COG0178@1|root,COG0178@2|Bacteria,4NFQU@976|Bacteroidetes,1HXMR@117743|Flavobacteriia 976|Bacteroidetes L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate uvrA2 - - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - ABC_tran k59_695718_2 344747.PM8797T_03484 1.3e-95 292.0 COG0500@1|root,COG2226@2|Bacteria,2IYB6@203682|Planctomycetes 203682|Planctomycetes Q Methylase involved in ubiquinone menaquinone - - 2.1.1.137 ko:K07755 - - - - ko00000,ko01000 - - - Methyltransf_31 k59_639466_1 631362.Thi970DRAFT_04735 2.17e-49 172.0 COG0845@1|root,COG0845@2|Bacteria,1MUFW@1224|Proteobacteria,1RQJ9@1236|Gammaproteobacteria,1WX1C@135613|Chromatiales 135613|Chromatiales M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - ko:K03585 ko01501,ko01503,map01501,map01503 M00646,M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000,ko03036 2.A.6.2,8.A.1.6 - - HlyD_D23 k59_131093_1 1122137.AQXF01000005_gene979 1.26e-64 206.0 COG0566@1|root,COG0566@2|Bacteria,1MWCM@1224|Proteobacteria,2TUG7@28211|Alphaproteobacteria 28211|Alphaproteobacteria J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family rlmB - 2.1.1.185 ko:K03218 - - - - ko00000,ko01000,ko03009 - - - SpoU_methylase,SpoU_sub_bind k59_131093_2 1122137.AQXF01000005_gene980 1.99e-31 114.0 COG3542@1|root,COG3542@2|Bacteria,1RHBE@1224|Proteobacteria,2U962@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Cupin superfamily MA20_39615 - - ko:K09705 - - - - ko00000 - - - Cupin_5 k59_752235_1 1123261.AXDW01000003_gene1997 1.7e-11 67.8 COG2271@1|root,COG2271@2|Bacteria,1MWYR@1224|Proteobacteria,1RR7T@1236|Gammaproteobacteria,1XC6N@135614|Xanthomonadales 135614|Xanthomonadales G Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 k59_752235_2 936455.KI421499_gene6948 1.75e-112 349.0 COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2TR2W@28211|Alphaproteobacteria,3JTTG@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria IQ AMP-binding enzyme C-terminal domain MA20_22985 - - ko:K00666 - - - - ko00000,ko01000,ko01004 - - - AMP-binding,AMP-binding_C k59_1599736_2 476272.RUMHYD_02845 3.77e-18 91.7 COG1783@1|root,COG1783@2|Bacteria,1TRQP@1239|Firmicutes,248E9@186801|Clostridia 186801|Clostridia L Phage terminase, large subunit, PBSX family - - - ko:K06909 - - - - ko00000 - - - Terminase_3,Terminase_3C k59_1712677_2 864051.BurJ1DRAFT_3887 0.000104 44.3 COG1028@1|root,COG1028@2|Bacteria,1MWB6@1224|Proteobacteria,2VIXS@28216|Betaproteobacteria,1KNH5@119065|unclassified Burkholderiales 28216|Betaproteobacteria IQ KR domain kduD - 1.1.1.69 ko:K00046 - - - - ko00000,ko01000 - - - adh_short,adh_short_C2 k59_75393_1 502025.Hoch_2597 2.44e-72 236.0 COG3581@1|root,COG3581@2|Bacteria,1R7UD@1224|Proteobacteria,42W9G@68525|delta/epsilon subdivisions,2X3M8@28221|Deltaproteobacteria,2YWH5@29|Myxococcales 28221|Deltaproteobacteria I 4 iron, 4 sulfur cluster binding - - - - - - - - - - - - - k59_1609498_1 1121374.KB891585_gene2395 8.2e-78 256.0 COG0188@1|root,COG0188@2|Bacteria,1MUGG@1224|Proteobacteria,1RN03@1236|Gammaproteobacteria 1236|Gammaproteobacteria L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrA GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003916,GO:0003918,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006265,GO:0006351,GO:0006725,GO:0006807,GO:0006996,GO:0008094,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017111,GO:0018130,GO:0019438,GO:0032774,GO:0034335,GO:0034641,GO:0034645,GO:0034654,GO:0042221,GO:0042493,GO:0042623,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051276,GO:0061505,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0097659,GO:0140097,GO:1901360,GO:1901362,GO:1901363,GO:1901576 5.99.1.3 ko:K02469 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseA_C,DNA_topoisoIV k59_1722244_1 439235.Dalk_3325 4.42e-07 59.3 COG1480@1|root,COG1480@2|Bacteria,1NCY5@1224|Proteobacteria,42MI9@68525|delta/epsilon subdivisions,2WJI1@28221|Deltaproteobacteria,2MI01@213118|Desulfobacterales 28221|Deltaproteobacteria S metal-dependent phosphohydrolase 7TM intracellular region - - - ko:K07037 - - - - ko00000 - - - 7TM-7TMR_HD,7TMR-HDED,HD k59_84883_1 702113.PP1Y_AT17165 1.1e-83 268.0 COG1505@1|root,COG1505@2|Bacteria,1NZ7N@1224|Proteobacteria,2TW70@28211|Alphaproteobacteria,2K10C@204457|Sphingomonadales 204457|Sphingomonadales E Prolyl oligopeptidase - - 3.4.21.26 ko:K01322 ko04614,map04614 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_S9,Peptidase_S9_N k59_532297_2 1472716.KBK24_0120330 5.21e-42 147.0 COG0329@1|root,COG0329@2|Bacteria,1NZA1@1224|Proteobacteria,2WB6I@28216|Betaproteobacteria,1KCPZ@119060|Burkholderiaceae 28216|Betaproteobacteria EM Dihydrodipicolinate synthetase family - - - - - - - - - - - - DHDPS k59_140363_1 765912.Thimo_1615 1.72e-50 168.0 COG0031@1|root,COG0031@2|Bacteria,1MUBE@1224|Proteobacteria,1RN6J@1236|Gammaproteobacteria,1WX3I@135613|Chromatiales 135613|Chromatiales E Belongs to the cysteine synthase cystathionine beta- synthase family - - 2.5.1.47 ko:K12339 ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230 M00021 R00897,R03132,R03601,R04859 RC00020,RC02814,RC02821,RC02876 ko00000,ko00001,ko00002,ko01000 - - - PALP k59_1383679_1 1056820.KB900629_gene1814 8.31e-140 420.0 28I5V@1|root,2Z891@2|Bacteria,1R3WS@1224|Proteobacteria,1RY0Y@1236|Gammaproteobacteria,2PN8W@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria S Cellulase N-terminal ig-like domain - - - - - - - - - - - - CelD_N,Glyco_hydro_9 k59_759175_1 1485544.JQKP01000012_gene2126 8.85e-84 256.0 COG0351@1|root,COG0351@2|Bacteria,1MU9J@1224|Proteobacteria,2VKD2@28216|Betaproteobacteria,44V55@713636|Nitrosomonadales 28216|Betaproteobacteria H Phosphomethylpyrimidine kinase thiD - 2.7.1.49,2.7.4.7 ko:K00941 ko00730,ko01100,map00730,map01100 M00127 R03471,R04509 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - Phos_pyr_kin k59_1045375_1 1397528.Q671_11615 1.8e-41 150.0 COG3213@1|root,COG3213@2|Bacteria,1MUJK@1224|Proteobacteria,1RMCR@1236|Gammaproteobacteria,1XJMJ@135619|Oceanospirillales 135619|Oceanospirillales P protein involved in response to NO nnrS - - ko:K07234 - - - - ko00000 - - - NnrS k59_705230_2 1030157.AFMP01000008_gene3258 2.23e-08 55.1 COG0718@1|root,COG0718@2|Bacteria,1RGZD@1224|Proteobacteria,2UBQB@28211|Alphaproteobacteria,2K5JW@204457|Sphingomonadales 204457|Sphingomonadales S Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection - - - ko:K09747 - - - - ko00000 - - - YbaB_DNA_bd k59_705230_3 883081.HMPREF9698_01082 3.33e-29 112.0 COG0353@1|root,COG0353@2|Bacteria,1TR87@1239|Firmicutes,4HAZR@91061|Bacilli,27F77@186828|Carnobacteriaceae 91061|Bacilli L May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO recR - - ko:K06187 ko03440,map03440 - - - ko00000,ko00001,ko03400 - - - RecR,Toprim_4 k59_1609519_1 1248232.BANQ01000071_gene1640 2.14e-26 103.0 COG2386@1|root,COG2386@2|Bacteria,1NJB0@1224|Proteobacteria,1RRFJ@1236|Gammaproteobacteria,1XSZY@135623|Vibrionales 135623|Vibrionales U Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes ccmB - - ko:K02194 ko02010,map02010 M00259 - - ko00000,ko00001,ko00002,ko02000 3.A.1.107 - - CcmB k59_1609519_2 1123070.KB899250_gene542 2.4e-11 68.9 COG3842@1|root,COG3842@2|Bacteria,46SFH@74201|Verrucomicrobia,2ITPH@203494|Verrucomicrobiae 203494|Verrucomicrobiae E ATPases associated with a variety of cellular activities - - - - - - - - - - - - ABC_tran,TOBE_2 k59_195051_1 247634.GPB2148_548 1.88e-60 192.0 COG0703@1|root,COG0703@2|Bacteria,1MUFJ@1224|Proteobacteria,1S40K@1236|Gammaproteobacteria 1236|Gammaproteobacteria F Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate aroK_2 - 2.7.1.71 ko:K00891 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02412 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - SKI k59_84898_1 448385.sce0178 8.5e-74 241.0 COG1858@1|root,COG1858@2|Bacteria,1RC4D@1224|Proteobacteria 1224|Proteobacteria C cytochrome C peroxidase - - - - - - - - - - - - - k59_1553684_1 1318628.MARLIPOL_03725 7.67e-26 104.0 COG4454@1|root,COG4454@2|Bacteria,1R91G@1224|Proteobacteria,1S5Y8@1236|Gammaproteobacteria,46DJJ@72275|Alteromonadaceae 1236|Gammaproteobacteria P Copper binding proteins, plastocyanin/azurin family - - - - - - - - - - - - Copper-bind,Cupredoxin_1 k59_984659_1 710243.XP_007593853.1 4.41e-22 97.1 COG1804@1|root,KOG3957@2759|Eukaryota,39K31@33154|Opisthokonta 33154|Opisthokonta I Domain of unknown function (DUF4387) - - - - - - - - - - - - AtuA,CoA_transf_3,DUF4387 k59_1045390_1 29730.Gorai.010G213800.1 2.74e-11 67.4 KOG1546@1|root,KOG1546@2759|Eukaryota,37IKY@33090|Viridiplantae,3GCHP@35493|Streptophyta 35493|Streptophyta DO AtMC9,MC9 - GO:0003674,GO:0003824,GO:0005575,GO:0005576,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008234,GO:0016787,GO:0019538,GO:0043170,GO:0044238,GO:0048046,GO:0070011,GO:0071704,GO:0140096,GO:1901564 - - - - - - - - - - Peptidase_C14 k59_84915_1 925409.KI911562_gene2704 7.52e-23 100.0 COG2273@1|root,COG2273@2|Bacteria,4NHP5@976|Bacteroidetes,1IY2Y@117747|Sphingobacteriia 976|Bacteroidetes G glycoside hydrolase family 16 - - - - - - - - - - - - CBM_6,Glyco_hydro_16 k59_591972_1 399739.Pmen_4455 5.37e-35 132.0 COG4324@1|root,COG4324@2|Bacteria,1N0FE@1224|Proteobacteria,1S0UK@1236|Gammaproteobacteria,1YE3V@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria S Putative aminopeptidase - - - - - - - - - - - - Aminopep k59_476885_1 1415778.JQMM01000001_gene1137 2.94e-15 75.9 2ASXF@1|root,31ID0@2|Bacteria,1RM30@1224|Proteobacteria,1S8I2@1236|Gammaproteobacteria,1JAB6@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_476885_2 1415778.JQMM01000001_gene1138 8.19e-49 162.0 COG0811@1|root,COG0811@2|Bacteria,1NXZ9@1224|Proteobacteria,1S154@1236|Gammaproteobacteria,1J4YC@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria U COG0811 Biopolymer transport proteins - - - - - - - - - - - - MotA_ExbB k59_591977_1 136993.KB900626_gene756 2.45e-48 168.0 COG0014@1|root,COG0014@2|Bacteria,1MUGJ@1224|Proteobacteria,2TS83@28211|Alphaproteobacteria,36XAH@31993|Methylocystaceae 28211|Alphaproteobacteria E Aldehyde dehydrogenase family proA GO:0003674,GO:0003824,GO:0004350,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0055114 1.2.1.41 ko:K00147 ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230 M00015 R03313 RC00684 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_476888_1 870187.Thini_0894 1.35e-29 119.0 COG3540@1|root,COG3540@2|Bacteria,1MWAF@1224|Proteobacteria,1RNY4@1236|Gammaproteobacteria,4637W@72273|Thiotrichales 72273|Thiotrichales P PhoD-like phosphatase, N-terminal domain - - - - - - - - - - - - PhoD,PhoD_N k59_1555073_2 857087.Metme_0709 4.61e-74 234.0 COG1660@1|root,COG1660@2|Bacteria,1MVX6@1224|Proteobacteria,1RNJX@1236|Gammaproteobacteria,1XE9S@135618|Methylococcales 135618|Methylococcales S Displays ATPase and GTPase activities - - - ko:K06958 - - - - ko00000,ko03019 - - - ATP_bind_2 k59_1610794_1 279238.Saro_1053 6.13e-58 202.0 COG1629@1|root,COG4771@2|Bacteria,1QURZ@1224|Proteobacteria,2U2N2@28211|Alphaproteobacteria,2KEB8@204457|Sphingomonadales 204457|Sphingomonadales P TonB dependent receptor - - - - - - - - - - - - Plug,TonB_dep_Rec k59_706501_2 1033802.SSPSH_001113 1.9e-53 180.0 COG0148@1|root,COG0148@2|Bacteria,1MU1N@1224|Proteobacteria,1RNQA@1236|Gammaproteobacteria 1236|Gammaproteobacteria G Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis eno GO:0000015,GO:0000287,GO:0003674,GO:0003824,GO:0004634,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005856,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009986,GO:0009987,GO:0016052,GO:0016053,GO:0016310,GO:0016829,GO:0016835,GO:0016836,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0032991,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042802,GO:0042866,GO:0043167,GO:0043169,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046872,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1902494 4.2.1.11 ko:K01689 ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066 M00001,M00002,M00003,M00346,M00394 R00658 RC00349 ko00000,ko00001,ko00002,ko01000,ko03019,ko04147 - - iPC815.YPO3376 Enolase_C,Enolase_N k59_533164_1 1121423.JONT01000015_gene1356 0.000725 44.7 COG2919@1|root,COG2919@2|Bacteria 2|Bacteria D cell cycle divIC - - ko:K05589,ko:K13052 - - - - ko00000,ko03036 - - - DivIC k59_29162_1 745014.OMB55_00003830 4.43e-86 266.0 COG0404@1|root,COG0404@2|Bacteria,1MV96@1224|Proteobacteria,1RN2A@1236|Gammaproteobacteria 1236|Gammaproteobacteria E The glycine cleavage system catalyzes the degradation of glycine - - 2.1.2.10 ko:K00605 ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200 M00532 R01221,R02300,R04125 RC00022,RC00069,RC00183,RC02834 ko00000,ko00001,ko00002,ko01000 - - - DUF1989,GCV_T,GCV_T_C k59_1214844_1 1178825.ALIH01000003_gene2095 1.62e-92 288.0 COG0204@1|root,COG3176@1|root,COG0204@2|Bacteria,COG3176@2|Bacteria,4NF25@976|Bacteroidetes,1HXD1@117743|Flavobacteriia 976|Bacteroidetes I glycerol acyltransferase - - - - - - - - - - - - Acetyltransf_5,Acyltransferase k59_477832_1 565045.NOR51B_122 9.49e-79 246.0 COG4638@1|root,COG4638@2|Bacteria,1MWXW@1224|Proteobacteria,1RQ0P@1236|Gammaproteobacteria,1JA4R@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P COG4638 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit - - - - - - - - - - - - Rieske,Ring_hydroxyl_A k59_593240_1 1123073.KB899241_gene2348 8.87e-64 203.0 COG0518@1|root,COG0518@2|Bacteria,1MUDH@1224|Proteobacteria,1RXUZ@1236|Gammaproteobacteria,1X60Y@135614|Xanthomonadales 135614|Xanthomonadales F Glutamine amidotransferase class-I - - 6.3.5.2 ko:K01951 ko00230,ko00983,ko01100,map00230,map00983,map01100 M00050 R01230,R01231,R08244 RC00010,RC00204 ko00000,ko00001,ko00002,ko01000,ko01002 - - - GATase k59_929862_1 1121937.AUHJ01000005_gene2183 1.31e-220 633.0 COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MUT8@1224|Proteobacteria,1RN6R@1236|Gammaproteobacteria,469XN@72275|Alteromonadaceae 1236|Gammaproteobacteria G PEP-utilising enzyme, TIM barrel domain ppdK - 2.7.1.202,2.7.3.9,2.7.9.1,2.7.9.2 ko:K01006,ko:K01007,ko:K02768,ko:K08483,ko:K11183 ko00051,ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,ko02060,map00051,map00620,map00680,map00710,map00720,map01100,map01120,map01200,map02060 M00169,M00171,M00172,M00173,M00273,M00374 R00199,R00206,R03232 RC00002,RC00015,RC00017,RC03206 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.2.1,8.A.7 - - PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C,PPDK_N,PTS-HPr,PTS_EIIA_2 k59_29183_1 1288494.EBAPG3_27460 2.85e-42 153.0 COG0497@1|root,COG0497@2|Bacteria,1MUNP@1224|Proteobacteria,2VHHA@28216|Betaproteobacteria,372RK@32003|Nitrosomonadales 28216|Betaproteobacteria L May be involved in recombinational repair of damaged DNA recN - - ko:K03631 - - - - ko00000,ko03400 - - - SMC_N k59_29183_2 1266925.JHVX01000010_gene1403 1.7e-45 155.0 COG0061@1|root,COG0061@2|Bacteria,1MUBC@1224|Proteobacteria,2VIV0@28216|Betaproteobacteria,372GT@32003|Nitrosomonadales 28216|Betaproteobacteria F Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP nadK - 2.7.1.23 ko:K00858 ko00760,ko01100,map00760,map01100 - R00104 RC00002,RC00078 ko00000,ko00001,ko01000 - - - NAD_kinase k59_1438137_1 1205680.CAKO01000038_gene1749 4.68e-26 106.0 COG1051@1|root,COG1051@2|Bacteria,1QU5T@1224|Proteobacteria,2TW0R@28211|Alphaproteobacteria 28211|Alphaproteobacteria F Nudix hydrolase - - - - - - - - - - - - NUDIX k59_816632_1 556268.OFAG_00814 1.54e-153 451.0 2EX9E@1|root,33QK4@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_877003_1 710696.Intca_0708 1.04e-24 105.0 COG1013@1|root,COG1013@2|Bacteria,2GMI5@201174|Actinobacteria,4FEAR@85021|Intrasporangiaceae 201174|Actinobacteria C 2-oxoacid ferredoxin oxidoreductase subunit beta korB - 1.2.7.11,1.2.7.3 ko:K00175 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C k59_929865_1 1122169.AREN01000027_gene1517 1.21e-19 85.1 COG0355@1|root,COG0355@2|Bacteria,1RHE4@1224|Proteobacteria,1S25H@1236|Gammaproteobacteria,1JEI4@118969|Legionellales 118969|Legionellales C Produces ATP from ADP in the presence of a proton gradient across the membrane atpC GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016469,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0045259,GO:0045261,GO:0046034,GO:0046390,GO:0046483,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - ko:K02114 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt_DE,ATP-synt_DE_N k59_929865_2 287.DR97_3441 1.02e-60 194.0 COG0625@1|root,COG0625@2|Bacteria,1RDQ5@1224|Proteobacteria,1S883@1236|Gammaproteobacteria,1YIGW@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria O Glutathione S-transferase, N-terminal domain - - - - - - - - - - - - GST_C_3,GST_N_3 k59_1665486_1 1118235.CAJH01000065_gene3564 6.4e-80 265.0 COG0086@1|root,COG0086@2|Bacteria,1MU3M@1224|Proteobacteria,1RPYH@1236|Gammaproteobacteria,1X3IQ@135614|Xanthomonadales 135614|Xanthomonadales K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoC GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234 2.7.7.6 ko:K03046 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5 k59_877004_1 913325.N799_14250 2.77e-55 185.0 COG0053@1|root,COG0053@2|Bacteria,1MVH8@1224|Proteobacteria,1RQ3E@1236|Gammaproteobacteria,1X2XD@135614|Xanthomonadales 135614|Xanthomonadales P cation diffusion facilitator family transporter - - - - - - - - - - - - Cation_efflux,ZT_dimer k59_1665489_1 190650.CC_1183 6.05e-78 239.0 COG0491@1|root,COG0491@2|Bacteria,1MUDN@1224|Proteobacteria,2TQJ9@28211|Alphaproteobacteria,2KG0M@204458|Caulobacterales 204458|Caulobacterales S Metallo-beta-lactamase superfamily - - - - - - - - - - - - Lactamase_B k59_1665489_2 767434.Fraau_2415 7.85e-14 68.2 COG1047@1|root,COG1047@2|Bacteria,1RD35@1224|Proteobacteria,1S3QR@1236|Gammaproteobacteria,1X69P@135614|Xanthomonadales 135614|Xanthomonadales O Peptidyl-prolyl cis-trans - - 5.2.1.8 ko:K03775 - - - - ko00000,ko01000,ko03110 - - - FKBP_C k59_253962_1 1122137.AQXF01000002_gene617 1.13e-201 585.0 COG5549@1|root,COG5549@2|Bacteria,1QVUS@1224|Proteobacteria 1224|Proteobacteria O Domain of unknown function (DUF5117) - - - - - - - - - - - - DUF4953,DUF5117 k59_196305_1 748449.Halha_0134 5.26e-49 173.0 COG2759@1|root,COG2759@2|Bacteria,1TP6N@1239|Firmicutes,247P5@186801|Clostridia,3WAEU@53433|Halanaerobiales 186801|Clostridia F PFAM Formate--tetrahydrofolate ligase fhs - 6.3.4.3 ko:K01938 ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200 M00140,M00377 R00943 RC00026,RC00111 ko00000,ko00001,ko00002,ko01000 - - - FTHFS k59_877013_2 436308.Nmar_0048 8.01e-130 378.0 COG0301@1|root,arCOG00038@2157|Archaea,41ST5@651137|Thaumarchaeota 651137|Thaumarchaeota H Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS - - - - - - - - - - - - - k59_877014_2 1415778.JQMM01000001_gene831 2.78e-56 182.0 COG1137@1|root,COG1137@2|Bacteria,1MU8M@1224|Proteobacteria,1RPW1@1236|Gammaproteobacteria,1J4XA@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S COG1137 ABC-type (unclassified) transport system, ATPase component lptB GO:0003674,GO:0003824,GO:0005215,GO:0005319,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006869,GO:0008150,GO:0010876,GO:0015221,GO:0015399,GO:0015405,GO:0015437,GO:0015920,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0031224,GO:0032991,GO:0033036,GO:0034040,GO:0042623,GO:0042626,GO:0043190,GO:0043492,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0098533,GO:0098796,GO:0098797,GO:1901264,GO:1901505,GO:1902494,GO:1902495,GO:1904949,GO:1990351 - ko:K06861 ko02010,map02010 M00320 - - ko00000,ko00001,ko00002,ko01000,ko02000 1.B.42.1 - - ABC_tran,BCA_ABC_TP_C k59_1723524_1 450851.PHZ_c2867 1.16e-68 217.0 COG0412@1|root,COG0412@2|Bacteria,1MW7S@1224|Proteobacteria,2TTPH@28211|Alphaproteobacteria,2KGFH@204458|Caulobacterales 204458|Caulobacterales Q Dienelactone hydrolase family - - 3.1.1.45 ko:K01061 ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130 - R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222 RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686 ko00000,ko00001,ko01000 - - - DLH k59_1723524_2 1229780.BN381_100185 3.87e-35 130.0 COG0235@1|root,COG0235@2|Bacteria,2GJ8W@201174|Actinobacteria 201174|Actinobacteria G Class II aldolase - - - - - - - - - - - - Aldolase_II k59_1325672_1 1122137.AQXF01000002_gene609 3.14e-82 252.0 COG0664@1|root,COG1716@1|root,COG0664@2|Bacteria,COG1716@2|Bacteria,1Q49P@1224|Proteobacteria,2UMKG@28211|Alphaproteobacteria 28211|Alphaproteobacteria T Cyclic nucleotide-monophosphate binding domain - - - ko:K10914 ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111 - - - ko00000,ko00001,ko03000 - - - FHA,cNMP_binding k59_647506_1 388399.SSE37_06104 9.33e-25 109.0 COG2370@1|root,COG2370@2|Bacteria,1MV6Z@1224|Proteobacteria,2TSX2@28211|Alphaproteobacteria 28211|Alphaproteobacteria O membrane - - - - - - - - - - - - HupE_UreJ_2 k59_647506_2 871585.BDGL_003584 3.01e-14 74.3 COG1473@1|root,COG1473@2|Bacteria,1MUIV@1224|Proteobacteria,1RQAM@1236|Gammaproteobacteria,3NMIP@468|Moraxellaceae 1236|Gammaproteobacteria S Peptidase dimerisation domain hipO - - ko:K01436 - - - - ko00000,ko01000,ko01002 - - - M20_dimer,Peptidase_M20 k59_1723530_2 566466.NOR53_2268 2.71e-62 197.0 COG0353@1|root,COG0353@2|Bacteria,1MV9Q@1224|Proteobacteria,1RN99@1236|Gammaproteobacteria,1J8HR@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO recR GO:0000731,GO:0006139,GO:0006259,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009411,GO:0009416,GO:0009628,GO:0009987,GO:0018130,GO:0019438,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:1901360,GO:1901362,GO:1901576 - ko:K06187 ko03440,map03440 - - - ko00000,ko00001,ko03400 - - - RecR,Toprim_4 k59_1776353_1 42256.RradSPS_1575 2.87e-28 107.0 COG0838@1|root,COG0838@2|Bacteria,2IKWT@201174|Actinobacteria,4CQ6Q@84995|Rubrobacteria 84995|Rubrobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoA - 1.6.5.3 ko:K00330 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q4 k59_985672_1 999541.bgla_2g14470 1.72e-80 253.0 COG1432@1|root,COG1432@2|Bacteria,1MX5C@1224|Proteobacteria,2VK44@28216|Betaproteobacteria,1KGZV@119060|Burkholderiaceae 28216|Betaproteobacteria NU NYN domain - - - - - - - - - - - - NYN,OST-HTH k59_1665516_1 391165.GbCGDNIH1_0434 6.39e-75 245.0 COG0769@1|root,COG0769@2|Bacteria,1MU6P@1224|Proteobacteria,2TVXI@28211|Alphaproteobacteria,2JQ77@204441|Rhodospirillales 204441|Rhodospirillales M Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan murE - 6.3.2.13 ko:K01928 ko00300,ko00550,map00300,map00550 - R02788 RC00064,RC00090 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_706574_1 1123256.KB907933_gene2266 2.13e-32 121.0 COG1024@1|root,COG1024@2|Bacteria,1R3U7@1224|Proteobacteria,1RRUT@1236|Gammaproteobacteria,1XA5W@135614|Xanthomonadales 135614|Xanthomonadales I Enoyl-CoA hydratase/isomerase - - - - - - - - - - - - ECH_1 k59_706574_2 1415780.JPOG01000001_gene1920 2.34e-143 417.0 COG2070@1|root,COG2070@2|Bacteria,1MWPC@1224|Proteobacteria,1RPZN@1236|Gammaproteobacteria,1X463@135614|Xanthomonadales 135614|Xanthomonadales S Nitronate monooxygenase - - - - - - - - - - - - NMO k59_647515_1 269797.Mbar_A1663 5.29e-112 333.0 COG1228@1|root,arCOG00696@2157|Archaea,2XWAY@28890|Euryarchaeota 28890|Euryarchaeota Q COG1228 Imidazolonepropionase and related amidohydrolases - - - - - - - - - - - - Amidohydro_1 k59_477875_1 696747.NIES39_Q02040 3.98e-10 58.5 COG0432@1|root,COG0432@2|Bacteria,1G5T5@1117|Cyanobacteria,1HB1Q@1150|Oscillatoriales 1117|Cyanobacteria S PFAM Uncharacterised protein family UPF0047 - - - - - - - - - - - - UPF0047 k59_477875_2 1144275.COCOR_05019 6.14e-14 73.2 COG2840@1|root,COG2840@2|Bacteria,1RH34@1224|Proteobacteria,42TQG@68525|delta/epsilon subdivisions,2WQG8@28221|Deltaproteobacteria 28221|Deltaproteobacteria S PFAM Smr protein MutS2 - - - - - - - - - - - - Smr k59_196351_1 1286106.MPL1_05734 2.29e-41 142.0 COG2930@1|root,COG2930@2|Bacteria,1RAIB@1224|Proteobacteria,1S5B7@1236|Gammaproteobacteria,463KN@72273|Thiotrichales 72273|Thiotrichales S Las17-binding protein actin regulator - - - - - - - - - - - - Ysc84 k59_647521_1 1384054.N790_11805 2.83e-18 84.0 COG2353@1|root,COG2353@2|Bacteria,1R9XD@1224|Proteobacteria,1T042@1236|Gammaproteobacteria,1X4RF@135614|Xanthomonadales 135614|Xanthomonadales S Belongs to the UPF0312 family - - - - - - - - - - - - YceI k59_533238_2 1229909.NSED_01290 6.62e-92 273.0 COG0852@1|root,arCOG01551@2157|Archaea,41SJS@651137|Thaumarchaeota 651137|Thaumarchaeota C NADH ubiquinone oxidoreductase 27 kD subunit - - 1.6.5.3 ko:K00332 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_30kDa k59_196365_1 1088721.NSU_2620 9.88e-110 333.0 COG0367@1|root,COG0367@2|Bacteria,1MW4E@1224|Proteobacteria,2TSCY@28211|Alphaproteobacteria,2JZZC@204457|Sphingomonadales 204457|Sphingomonadales E Asparagine synthase - - 6.3.5.4 ko:K01953 ko00250,ko01100,ko01110,map00250,map01100,map01110 - R00578 RC00010 ko00000,ko00001,ko01000,ko01002 - - - Asn_synthase,GATase_7 k59_1157220_1 1229909.NSED_01530 4.35e-117 345.0 COG0148@1|root,arCOG01169@2157|Archaea,41SE9@651137|Thaumarchaeota 651137|Thaumarchaeota G Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis eno - 4.2.1.11 ko:K01689 ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066 M00001,M00002,M00003,M00346,M00394 R00658 RC00349 ko00000,ko00001,ko00002,ko01000,ko03019,ko04147 - - - Enolase_C,Enolase_N k59_477891_1 316407.85674602 2.4e-116 342.0 COG0845@1|root,COG0845@2|Bacteria,1MU78@1224|Proteobacteria,1RPI1@1236|Gammaproteobacteria,3XM5Z@561|Escherichia 1236|Gammaproteobacteria M AcrA-AcrB-AcrZ-TolC is a drug efflux protein complex with broad substrate specificity that uses the proton motive force to export substrates. This subunit may act as an adapter protein that links AcrB and TolC stably together acrA GO:0003674,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006820,GO:0006855,GO:0006869,GO:0008150,GO:0010876,GO:0015238,GO:0015711,GO:0015718,GO:0015721,GO:0015849,GO:0015850,GO:0015893,GO:0016020,GO:0016021,GO:0022857,GO:0030288,GO:0030313,GO:0031224,GO:0031226,GO:0031975,GO:0032991,GO:0033036,GO:0042221,GO:0042493,GO:0042597,GO:0042802,GO:0044425,GO:0044459,GO:0044464,GO:0046677,GO:0046942,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0098796,GO:1902495,GO:1990281,GO:1990351 - ko:K03585,ko:K18141 ko01501,ko01503,map01501,map01503 M00646,M00647,M00696,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000,ko03036 2.A.6.2,8.A.1,8.A.1.6 - iSDY_1059.SDY_0456 Biotin_lipoyl_2,HlyD,HlyD_3,HlyD_D23 k59_760174_1 187272.Mlg_1947 5.44e-05 43.5 COG0858@1|root,COG0858@2|Bacteria,1MZPE@1224|Proteobacteria,1S9AF@1236|Gammaproteobacteria 1236|Gammaproteobacteria J One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA rbfA GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009266,GO:0009409,GO:0009628,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0022613,GO:0030490,GO:0033554,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0042274,GO:0043021,GO:0043024,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071840,GO:0090304,GO:1901360 - ko:K02834 - - - - ko00000,ko03009 - - - RBFA k59_706611_1 1088721.NSU_0705 2.35e-97 301.0 COG0544@1|root,COG0544@2|Bacteria,1MUJP@1224|Proteobacteria,2TS8W@28211|Alphaproteobacteria,2K02U@204457|Sphingomonadales 204457|Sphingomonadales D Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase tig GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - ko:K03545 - - - - ko00000 - - - FKBP_C,Trigger_C,Trigger_N k59_1268900_1 395493.BegalDRAFT_3404 2.21e-57 188.0 COG0739@1|root,COG0739@2|Bacteria,1MY2X@1224|Proteobacteria,1RMYN@1236|Gammaproteobacteria,460J5@72273|Thiotrichales 72273|Thiotrichales M PFAM Peptidase family M23 - - - - - - - - - - - - Peptidase_M23 k59_1214949_1 1229909.NSED_06260 8.61e-113 337.0 COG0119@1|root,arCOG02092@2157|Archaea,41SBX@651137|Thaumarchaeota 651137|Thaumarchaeota E Belongs to the alpha-IPM synthase homocitrate synthase family - - 2.3.3.13 ko:K01649 ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230 M00432 R01213 RC00004,RC00470,RC02754 br01601,ko00000,ko00001,ko00002,ko01000 - - - HMGL-like,LeuA_dimer k59_985705_1 384676.PSEEN4252 3.24e-96 292.0 COG0460@1|root,COG0460@2|Bacteria,1MUDC@1224|Proteobacteria,1RPEU@1236|Gammaproteobacteria 1236|Gammaproteobacteria E homoserine dehydrogenase hom - 1.1.1.3,2.7.2.4 ko:K00003,ko:K12524 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00017,M00018,M00526,M00527 R00480,R01773,R01775 RC00002,RC00043,RC00087 ko00000,ko00001,ko00002,ko01000 - - - ACT,Homoserine_dh,NAD_binding_3 k59_1157229_1 1449076.JOOE01000001_gene2097 1.05e-54 201.0 COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TR8X@28211|Alphaproteobacteria,2K0ZS@204457|Sphingomonadales 204457|Sphingomonadales T nitrogen fixation sensor protein fixL - - 2.7.13.3 ko:K14986 ko02020,map02020 M00524 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - DUF4118,HATPase_c,HisKA,PAS,PAS_9 k59_1566796_1 1484460.JSWG01000008_gene1825 1.35e-101 305.0 COG1960@1|root,COG1960@2|Bacteria,4NFD4@976|Bacteroidetes,1HWQD@117743|Flavobacteriia 976|Bacteroidetes I acyl-CoA dehydrogenase - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_939169_1 1122604.JONR01000008_gene2127 4.13e-74 240.0 COG2114@1|root,COG2114@2|Bacteria,1MV1V@1224|Proteobacteria,1RYBQ@1236|Gammaproteobacteria,1X5EM@135614|Xanthomonadales 135614|Xanthomonadales T Adenylyl- / guanylyl cyclase, catalytic domain - - - - - - - - - - - - Guanylate_cyc k59_604902_1 702113.PP1Y_Mpl10172 6.22e-66 226.0 COG3250@1|root,COG3250@2|Bacteria,1P9KJ@1224|Proteobacteria,2UZ0A@28211|Alphaproteobacteria,2K315@204457|Sphingomonadales 204457|Sphingomonadales G alpha-L-rhamnosidase - - - - - - - - - - - - Glyco_hydro_106 k59_40056_1 1278073.MYSTI_03335 5.28e-83 271.0 COG0553@1|root,COG0553@2|Bacteria,1MV6M@1224|Proteobacteria,42M5P@68525|delta/epsilon subdivisions,2WIW8@28221|Deltaproteobacteria,2YUB7@29|Myxococcales 28221|Deltaproteobacteria KL Superfamily II DNA RNA helicases, SNF2 family - - - - - - - - - - - - Helicase_C,SNF2_N,SWIM k59_379725_1 322710.Avin_20640 7.18e-71 221.0 COG1443@1|root,COG1443@2|Bacteria,1R9YJ@1224|Proteobacteria,1S6ZT@1236|Gammaproteobacteria 1236|Gammaproteobacteria I Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) idi GO:0003674,GO:0003824,GO:0004452,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006629,GO:0006644,GO:0006720,GO:0006793,GO:0006796,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016853,GO:0016860,GO:0016863,GO:0019637,GO:0033554,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044464,GO:0046490,GO:0050896,GO:0051716,GO:0071704,GO:0090407,GO:1901576 5.3.3.2 ko:K01823 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00095,M00096,M00364,M00365,M00366,M00367 R01123 RC00455 ko00000,ko00001,ko00002,ko01000 - - iECH74115_1262.ECH74115_4179,iECIAI1_1343.ECIAI1_3008,iECO103_1326.ECO103_3464,iECSP_1301.ECSP_3858,iECs_1301.ECs3761,iEcE24377_1341.EcE24377A_3215,iG2583_1286.G2583_3542,iSFV_1184.SFV_2937,iSF_1195.SF2875,iSFxv_1172.SFxv_3153,iSSON_1240.SSON_3042,iS_1188.S3074,iZ_1308.Z4227 NUDIX k59_1568019_1 1122137.AQXF01000005_gene1198 3.67e-147 427.0 COG0213@1|root,COG0213@2|Bacteria,1MV3H@1224|Proteobacteria,2TS24@28211|Alphaproteobacteria 28211|Alphaproteobacteria F The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis deoA - 2.4.2.4 ko:K00758 ko00240,ko00983,ko01100,ko05219,map00240,map00983,map01100,map05219 - R01570,R02484,R08222,R08230 RC00063 ko00000,ko00001,ko01000 - - - Glycos_trans_3N,Glycos_transf_3,PYNP_C k59_1335547_1 1320556.AVBP01000011_gene3333 1.02e-73 231.0 COG3246@1|root,COG3246@2|Bacteria,1MZTP@1224|Proteobacteria,2TQKN@28211|Alphaproteobacteria,43J5G@69277|Phyllobacteriaceae 28211|Alphaproteobacteria S beta-keto acid cleavage enzyme - - - - - - - - - - - - BKACE k59_658033_1 316407.1736878 7.3e-135 392.0 COG2031@1|root,COG2031@2|Bacteria,1MV5A@1224|Proteobacteria,1RMTZ@1236|Gammaproteobacteria,3XN8R@561|Escherichia 1236|Gammaproteobacteria I Short chain fatty acid transporter atoE GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K02106 ko02020,map02020 - - - ko00000,ko00001 2.A.73.1 - iECUMN_1333.ECUMN_2561 SCFA_trans k59_1510511_1 1313421.JHBV01000015_gene5729 6.07e-35 133.0 COG4409@1|root,COG4409@2|Bacteria 2|Bacteria G exo-alpha-(2->6)-sialidase activity - - - - - - - - - - - - BNR_2,Gram_pos_anchor k59_1225479_1 234267.Acid_2503 1.57e-22 93.2 COG1438@1|root,COG1438@2|Bacteria,3Y551@57723|Acidobacteria 57723|Acidobacteria K Regulates arginine biosynthesis genes argR - - ko:K03402 - - - - ko00000,ko03000 - - - Arg_repressor,Arg_repressor_C k59_1225479_2 1123008.KB905694_gene1703 1.94e-92 288.0 COG0137@1|root,COG0137@2|Bacteria,4NE3R@976|Bacteroidetes,2FMRA@200643|Bacteroidia,22X17@171551|Porphyromonadaceae 976|Bacteroidetes E argininosuccinate synthase argG - 6.3.4.5 ko:K01940 ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418 M00029,M00844,M00845 R01954 RC00380,RC00629 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Arginosuc_synth k59_1785411_1 436308.Nmar_0070 6.7e-24 91.7 arCOG08820@1|root,arCOG08820@2157|Archaea,41SWF@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_432055_2 1131266.ARWQ01000004_gene1449 2.87e-13 69.7 COG0715@1|root,arCOG01803@2157|Archaea,41SG5@651137|Thaumarchaeota 651137|Thaumarchaeota P TIGRFAM ABC transporter, substrate-binding protein, aliphatic sulfonates family - - - ko:K02051 - M00188 - - ko00000,ko00002,ko02000 3.A.1.16,3.A.1.17 - - NMT1_2 k59_324391_1 1121923.GPUN_0387 5.99e-93 285.0 COG3748@1|root,COG3748@2|Bacteria,1MWHB@1224|Proteobacteria,1RRV4@1236|Gammaproteobacteria,46A4Z@72275|Alteromonadaceae 1236|Gammaproteobacteria S Urate oxidase N-terminal - - - - - - - - - - - - Urate_ox_N k59_208906_1 243232.MJ_0203 6.68e-22 95.9 COG0150@1|root,arCOG00639@2157|Archaea,2XTBA@28890|Euryarchaeota,23Q83@183939|Methanococci 183939|Methanococci F AIR synthase related protein domain protein purM - 6.3.3.1 ko:K01933 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04208 RC01100 ko00000,ko00001,ko00002,ko01000 - - - AIRS,AIRS_C k59_1335561_1 1219049.SP5_095_00170 1.83e-54 184.0 COG4191@1|root,COG4191@2|Bacteria,1RCNQ@1224|Proteobacteria,2TYSZ@28211|Alphaproteobacteria,2KEND@204457|Sphingomonadales 2|Bacteria T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c k59_1278874_2 1229909.NSED_03465 1.42e-45 157.0 COG0517@1|root,arCOG00600@2157|Archaea 2157|Archaea K CBS domain - - - ko:K07182 - - - - ko00000 - - - CBS k59_770222_1 446470.Snas_1964 4.95e-63 202.0 COG0462@1|root,COG0462@2|Bacteria,2GJ9S@201174|Actinobacteria,4EXZH@85014|Glycomycetales 201174|Actinobacteria EF Phosphoribosyl synthetase-associated domain prs - 2.7.6.1 ko:K00948 ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230 M00005 R01049 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - Pribosyl_synth,Pribosyltran_N k59_208910_1 572477.Alvin_0393 3.69e-63 202.0 COG1211@1|root,COG1211@2|Bacteria,1MY3B@1224|Proteobacteria,1S21S@1236|Gammaproteobacteria,1WXHT@135613|Chromatiales 135613|Chromatiales I Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) ispD - 2.7.7.60 ko:K00991 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05633 RC00002 ko00000,ko00001,ko00002,ko01000 - - - IspD k59_208910_2 1265503.KB905161_gene3026 1.76e-17 78.6 COG2919@1|root,COG2919@2|Bacteria,1N7AA@1224|Proteobacteria,1SD8H@1236|Gammaproteobacteria,2Q76Q@267889|Colwelliaceae 1236|Gammaproteobacteria D Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic ftsB GO:0000003,GO:0000910,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0007049,GO:0008150,GO:0009987,GO:0019954,GO:0022402,GO:0022414,GO:0030428,GO:0032153,GO:0032505,GO:0042802,GO:0043093,GO:0044464,GO:0051301 - ko:K05589 - - - - ko00000,ko03036 - - - DivIC k59_1397570_1 316407.85676478 2.55e-59 194.0 COG2115@1|root,COG2115@2|Bacteria,1MXS2@1224|Proteobacteria,1RN5Y@1236|Gammaproteobacteria,3XMQW@561|Escherichia 1236|Gammaproteobacteria G Belongs to the xylose isomerase family xylA GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0005996,GO:0008150,GO:0008152,GO:0009045,GO:0009056,GO:0016052,GO:0016853,GO:0016860,GO:0016861,GO:0019321,GO:0019323,GO:0042732,GO:0042843,GO:0044238,GO:0044281,GO:0044282,GO:0044424,GO:0044464,GO:0046365,GO:0071704,GO:1901575 5.3.1.5 ko:K01805 ko00040,ko00051,ko01100,map00040,map00051,map01100 - R00878,R01432 RC00376,RC00516 ko00000,ko00001,ko01000 - - iECO26_1355.ECO26_5036,iPC815.YPO4038 - k59_1397570_2 316407.85676479 1.24e-35 131.0 COG1070@1|root,COG1070@2|Bacteria,1MW4A@1224|Proteobacteria,1RR7X@1236|Gammaproteobacteria,3XNNY@561|Escherichia 1236|Gammaproteobacteria F xylulose metabolic process xylB GO:0003674,GO:0003824,GO:0004856,GO:0005975,GO:0005996,GO:0005997,GO:0005998,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016052,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019200,GO:0019321,GO:0019323,GO:0042732,GO:0042843,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0046365,GO:0046835,GO:0071704,GO:1901575 2.7.1.17 ko:K00854 ko00040,ko01100,map00040,map01100 M00014 R01639 RC00002,RC00538 ko00000,ko00001,ko00002,ko01000 - - iAPECO1_1312.APECO1_2885,iEC55989_1330.EC55989_4019,iECIAI1_1343.ECIAI1_3729,iECO103_1326.ECO103_4670,iECO111_1330.ECO111_4384,iECO26_1355.ECO26_5037,iECOK1_1307.ECOK1_4011,iECP_1309.ECP_3667,iECS88_1305.ECS88_3982,iECSE_1348.ECSE_3838,iECW_1372.ECW_m3838,iEKO11_1354.EKO11_0162,iUMN146_1321.UM146_17990,iUTI89_1310.UTI89_C4105,iWFL_1372.ECW_m3838 FGGY_C,FGGY_N k59_1225491_1 1439940.BAY1663_00496 2.78e-164 469.0 COG4177@1|root,COG4177@2|Bacteria,1MUPI@1224|Proteobacteria,1RMAZ@1236|Gammaproteobacteria 1236|Gammaproteobacteria E Belongs to the binding-protein-dependent transport system permease family fmdF - - ko:K01998,ko:K11961 ko02010,ko02024,map02010,map02024 M00237,M00323 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4,3.A.1.4.4,3.A.1.4.5 - - BPD_transp_2 k59_1225491_2 1523503.JPMY01000010_gene2687 1.12e-29 113.0 COG0559@1|root,COG0559@2|Bacteria,1MVND@1224|Proteobacteria,1RQXD@1236|Gammaproteobacteria 1236|Gammaproteobacteria E Belongs to the binding-protein-dependent transport system permease family - - - ko:K11960 ko02010,map02010 M00323 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4.4,3.A.1.4.5 - - BPD_transp_2 k59_266237_1 553385.JEMF01000050_gene2186 1.28e-20 90.5 COG0508@1|root,COG0508@2|Bacteria,1MUJD@1224|Proteobacteria,1RME0@1236|Gammaproteobacteria,1XHYG@135619|Oceanospirillales 135619|Oceanospirillales C The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) sucB - 2.3.1.61 ko:K00658 ko00020,ko00310,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00032 R02570,R02571,R08549 RC00004,RC02727,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - 2-oxoacid_dh,Biotin_lipoyl,E3_binding k59_266237_2 1298593.TOL_1496 2.92e-37 137.0 COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,1RMFF@1236|Gammaproteobacteria,1XH5E@135619|Oceanospirillales 135619|Oceanospirillales C 2-oxoglutarate dehydrogenase complex lpdG - 1.8.1.4 ko:K00382 ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00036,M00307,M00532 R00209,R01221,R01698,R03815,R07618,R08549 RC00004,RC00022,RC00583,RC02742,RC02833,RC02834 br01601,ko00000,ko00001,ko00002,ko01000,ko04147 - - - Pyr_redox_2,Pyr_redox_dim k59_940527_1 9778.XP_004381822.1 1.51e-29 116.0 COG1335@1|root,KOG4044@2759|Eukaryota,39X6I@33154|Opisthokonta,3BIK9@33208|Metazoa,3CZM3@33213|Bilateria,489ZR@7711|Chordata,48YJV@7742|Vertebrata,3J1QA@40674|Mammalia,34SQ4@311790|Afrotheria 33208|Metazoa Q Isochorismatase domain-containing protein 2, mitochondrial ISOC2 GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0008150,GO:0031647,GO:0031648,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044464,GO:0065007,GO:0065008 - - - - - - - - - - Isochorismatase k59_1335573_1 1229909.NSED_04630 3.17e-164 470.0 COG0183@1|root,arCOG01278@2157|Archaea,41SB7@651137|Thaumarchaeota 651137|Thaumarchaeota I Thiolase, N-terminal domain - - 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N k59_770236_1 243231.GSU2706 2.63e-16 79.0 COG0280@1|root,COG0280@2|Bacteria,1QTS5@1224|Proteobacteria,42MPY@68525|delta/epsilon subdivisions,2WJ2V@28221|Deltaproteobacteria,43UJR@69541|Desulfuromonadales 28221|Deltaproteobacteria H PFAM phosphate acetyl butaryl transferase pta - 2.3.1.8 ko:K00625,ko:K13788 ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200 M00357,M00579 R00230,R00921 RC00004,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_1035 AAA_26,DRTGG,PTA_PTB k59_770236_2 479434.Sthe_2814 6.64e-49 170.0 COG0439@1|root,COG0439@2|Bacteria,2G62X@200795|Chloroflexi,27YU8@189775|Thermomicrobia 189775|Thermomicrobia I acetyl-CoA carboxylase, biotin carboxylase - - 6.3.4.14,6.4.1.2 ko:K01961 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04385 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 - - - Biotin_carb_C,Biotin_carb_N,CPSase_L_D2 k59_41251_1 316407.1799672 1.05e-127 364.0 COG0625@1|root,COG0625@2|Bacteria,1NX28@1224|Proteobacteria,1RQUP@1236|Gammaproteobacteria,3XNIX@561|Escherichia 1236|Gammaproteobacteria O however this activity is as low as 1 of that of GstA. Also displays a GSH-dependent peroxidase activity toward cumene hydroperoxide. Is involved in defense against oxidative stress, probably via its peroxidase activity yfcF GO:0000302,GO:0003674,GO:0003824,GO:0004364,GO:0006950,GO:0006979,GO:0008150,GO:0009636,GO:0010035,GO:0016740,GO:0016765,GO:0042221,GO:0042493,GO:0042542,GO:0046677,GO:0050896,GO:1901700 2.5.1.18 ko:K00799 ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418 - R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905 RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944 ko00000,ko00001,ko01000,ko02000 1.A.12.2.2,1.A.12.3.2 - iECW_1372.ECW_m2490,iWFL_1372.ECW_m2490 GST_C_4,GST_N,GST_N_3 k59_1568060_2 1229909.NSED_09695 3.75e-38 128.0 arCOG11529@1|root,arCOG11529@2157|Archaea,41TAA@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1568060_3 436308.Nmar_0011 4.82e-26 107.0 COG0464@1|root,arCOG01308@2157|Archaea,41SX8@651137|Thaumarchaeota 651137|Thaumarchaeota O Cell division protein 48 (CDC48), domain 2 - - - ko:K13525 ko04141,ko05134,map04141,map05134 M00400,M00403 - - ko00000,ko00001,ko00002,ko03019,ko04131,ko04147 3.A.16.1 - - AAA,CDC48_2,CDC48_N k59_1785433_1 330214.NIDE1678 2.2e-49 166.0 COG1214@1|root,COG1214@2|Bacteria,3J0VU@40117|Nitrospirae 40117|Nitrospirae O Glycoprotease family - - - ko:K14742 - - - - ko00000,ko03016 - - - Peptidase_M22 k59_1733571_1 1005048.CFU_1187 2.78e-50 171.0 COG0745@1|root,COG0745@2|Bacteria,1MY3D@1224|Proteobacteria,2VI0K@28216|Betaproteobacteria,473K3@75682|Oxalobacteraceae 28216|Betaproteobacteria K COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain - - - ko:K02483 - - - - ko00000,ko02022 - - - Response_reg,Trans_reg_C k59_658062_1 1123320.KB889686_gene654 3.83e-13 68.2 COG2128@1|root,COG2128@2|Bacteria,2H4IP@201174|Actinobacteria 201174|Actinobacteria S carboxymuconolactone decarboxylase - - - - - - - - - - - - CMD k59_208924_1 765914.ThisiDRAFT_2708 6.18e-14 70.5 COG0030@1|root,COG0030@2|Bacteria,1MVNU@1224|Proteobacteria,1RMHW@1236|Gammaproteobacteria,1WWC4@135613|Chromatiales 135613|Chromatiales J Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits ksgA - 2.1.1.182 ko:K02528 - - R10716 RC00003,RC03257 ko00000,ko01000,ko03009 - - - RrnaAD k59_208924_2 713587.THITH_06285 6.32e-55 182.0 COG1995@1|root,COG1995@2|Bacteria,1MX5W@1224|Proteobacteria,1RNZV@1236|Gammaproteobacteria,1WWTH@135613|Chromatiales 135613|Chromatiales H Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) pdxA - 1.1.1.262 ko:K00097 ko00750,ko01100,map00750,map01100 M00124 R05681,R05837,R07406 RC00089,RC00675,RC01475 ko00000,ko00001,ko00002,ko01000 - - - PdxA k59_1225511_1 100226.SCO5506 6.02e-08 60.1 COG2909@1|root,COG2909@2|Bacteria,2GJAR@201174|Actinobacteria 201174|Actinobacteria K transcriptional regulator - - - - - - - - - - - - AAA_16,GerE k59_151355_1 316407.85675607 4.09e-115 340.0 COG4948@1|root,COG4948@2|Bacteria,1NAKW@1224|Proteobacteria,1RN9M@1236|Gammaproteobacteria,3XMB0@561|Escherichia 1236|Gammaproteobacteria M Does not seem to have an in-vivo activity on glucarate or idarate. Its real substrate is gudX GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0044237,GO:0044248 4.2.1.40 ko:K01706,ko:K13918 ko00053,ko01100,map00053,map01100 - R02752,R08056 RC00543 ko00000,ko00001,ko01000 - - iECIAI39_1322.ECIAI39_3210 MR_MLE_C,MR_MLE_N k59_1057604_1 1502770.JQMG01000001_gene2056 8.85e-67 205.0 COG0780@1|root,COG0780@2|Bacteria,1MW0M@1224|Proteobacteria,2VINU@28216|Betaproteobacteria,2KMK5@206350|Nitrosomonadales 206350|Nitrosomonadales S Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) queF - 1.7.1.13 ko:K09457 ko00790,ko01100,map00790,map01100 - R07605 RC01875 ko00000,ko00001,ko01000,ko03016 - - - QueF k59_658065_2 626887.J057_19335 3.21e-22 92.8 COG4103@1|root,COG4103@2|Bacteria,1N6YZ@1224|Proteobacteria,1SD1K@1236|Gammaproteobacteria,468DI@72275|Alteromonadaceae 1236|Gammaproteobacteria S protein conserved in bacteria - - - - - - - - - - - - TerB k59_1620936_1 1392490.JHZX01000001_gene991 1.79e-17 79.3 COG1314@1|root,COG1314@2|Bacteria,4NUYQ@976|Bacteroidetes,1I418@117743|Flavobacteriia 976|Bacteroidetes U Preprotein translocase secG - - ko:K03075 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2 - - SecG k59_1620936_2 398720.MED217_03525 6.04e-07 50.1 28HHN@1|root,2Z7TA@2|Bacteria,4NEXR@976|Bacteroidetes,1HZ4X@117743|Flavobacteriia,2XIZK@283735|Leeuwenhoekiella 976|Bacteroidetes S Psort location Cytoplasmic, score 8.96 - - - - - - - - - - - - - k59_1225512_1 436308.Nmar_0001 5.47e-12 64.7 COG1474@1|root,arCOG00467@2157|Archaea,41SED@651137|Thaumarchaeota 651137|Thaumarchaeota L Involved in regulation of DNA replication - - - ko:K10725 - - - - ko00000,ko03032 - - - AAA_22,Cdc6_C k59_1225512_2 436308.Nmar_0002 4.25e-181 514.0 COG1311@1|root,arCOG04455@2157|Archaea,41T0D@651137|Thaumarchaeota 651137|Thaumarchaeota L Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase polB - 2.7.7.7 ko:K02323 ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030 M00264 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032 - - - DNA_pol_E_B k59_1785441_1 582899.Hden_0708 2.98e-40 142.0 COG3293@1|root,COG3293@2|Bacteria,1PVIT@1224|Proteobacteria,2TURP@28211|Alphaproteobacteria,3N8G4@45401|Hyphomicrobiaceae 28211|Alphaproteobacteria L Transposase DDE domain - - - - - - - - - - - - DDE_Tnp_1,DUF4096 k59_719309_1 1122134.KB893650_gene1403 9e-19 85.9 COG0508@1|root,COG0508@2|Bacteria,1MVDC@1224|Proteobacteria,1RQ9Y@1236|Gammaproteobacteria,1XHMK@135619|Oceanospirillales 135619|Oceanospirillales C Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex - - 2.3.1.12,2.3.1.168 ko:K00627,ko:K09699 ko00010,ko00020,ko00280,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00280,map00620,map00640,map01100,map01110,map01120,map01130,map01200 M00036,M00307 R00209,R02569,R02662,R03174,R04097,R10998 RC00004,RC02727,RC02742,RC02857,RC02870 br01601,ko00000,ko00001,ko00002,ko01000 - - - 2-oxoacid_dh,Biotin_lipoyl,E3_binding k59_719309_2 1121935.AQXX01000144_gene4439 2.35e-36 129.0 COG0695@1|root,COG0695@2|Bacteria,1N12W@1224|Proteobacteria,1SB6J@1236|Gammaproteobacteria,1XQX0@135619|Oceanospirillales 135619|Oceanospirillales O Domain of unknown function (DUF4124) - - - - - - - - - - - - DUF4124,Glutaredoxin k59_719309_3 1198232.CYCME_0771 2.12e-40 136.0 COG0203@1|root,COG0203@2|Bacteria,1RCWN@1224|Proteobacteria,1S3QK@1236|Gammaproteobacteria,460U0@72273|Thiotrichales 72273|Thiotrichales J Ribosomal protein L17 rplQ - - ko:K02879 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L17 k59_940539_2 550540.Fbal_3448 1.84e-21 90.5 2BWJV@1|root,32U7J@2|Bacteria,1N47S@1224|Proteobacteria,1SAYP@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - Frag1 k59_889425_2 1197130.BAFM01000005_gene1190 1.35e-79 266.0 COG2333@1|root,arCOG03009@2157|Archaea,2Y2NK@28890|Euryarchaeota,23ZB3@183963|Halobacteria 183963|Halobacteria S hydrolase (metallo-beta-lactamase superfamily) - - - - - - - - - - - - An_peroxidase k59_889425_3 69395.JQLZ01000014_gene4006 2.96e-28 107.0 COG0346@1|root,COG0346@2|Bacteria,1RH8G@1224|Proteobacteria,2U9BR@28211|Alphaproteobacteria,2KK33@204458|Caulobacterales 204458|Caulobacterales E COG0346 Lactoylglutathione lyase and related lyases - - - - - - - - - - - - - k59_151365_1 158500.BV97_00048 7.25e-66 210.0 COG1946@1|root,COG1946@2|Bacteria,1MV9R@1224|Proteobacteria,2TRFD@28211|Alphaproteobacteria,2K289@204457|Sphingomonadales 204457|Sphingomonadales I Acyl-CoA thioesterase - - - ko:K10805 ko01040,map01040 - - - ko00000,ko00001,ko01000,ko01004 - - - 4HBT_3 k59_940543_1 983917.RGE_35800 7.45e-67 210.0 COG0680@1|root,COG0680@2|Bacteria,1RE1C@1224|Proteobacteria,2VJ4W@28216|Betaproteobacteria,1KISY@119065|unclassified Burkholderiales 28216|Betaproteobacteria C Hydrogenase maturation protease hoxM - - ko:K03605 - - - - ko00000,ko01000,ko01002 - - - HycI k59_151369_1 880072.Desac_2720 7.11e-11 62.0 COG1136@1|root,COG1136@2|Bacteria,1MVSQ@1224|Proteobacteria,42QNS@68525|delta/epsilon subdivisions,2WMSN@28221|Deltaproteobacteria,2MQF7@213462|Syntrophobacterales 28221|Deltaproteobacteria V Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner lolD - - ko:K09810 ko02010,map02010 M00255 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.125 - - ABC_tran k59_151369_2 1562701.BBOF01000081_gene224 8.87e-29 116.0 COG4591@1|root,COG4591@2|Bacteria,1MVV7@1224|Proteobacteria,2VH7C@28216|Betaproteobacteria,1K125@119060|Burkholderiaceae 28216|Betaproteobacteria M lipoprotein releasing system, transmembrane protein, LolC E family lolC - - ko:K09808 ko02010,map02010 M00255 - - ko00000,ko00001,ko00002,ko02000 3.A.1.125 - - FtsX,MacB_PCD k59_324441_1 2340.JV46_14000 2.11e-59 211.0 COG1074@1|root,COG1074@2|Bacteria,1MUTF@1224|Proteobacteria,1RPC6@1236|Gammaproteobacteria,1J4ZX@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L Belongs to the helicase family. UvrD subfamily addA - - - - - - - - - - - PDDEXK_1,UvrD-helicase,UvrD_C k59_1568109_1 1038859.AXAU01000005_gene5005 5.09e-50 177.0 COG2272@1|root,COG2272@2|Bacteria,1MVQZ@1224|Proteobacteria,2TUA9@28211|Alphaproteobacteria,3JRPT@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria I Carboxylesterase family - GO:0001503,GO:0001505,GO:0001507,GO:0001540,GO:0001649,GO:0002076,GO:0002791,GO:0002793,GO:0003674,GO:0003824,GO:0003990,GO:0004104,GO:0005488,GO:0005515,GO:0005518,GO:0005575,GO:0005576,GO:0005604,GO:0005605,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005794,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006581,GO:0006629,GO:0006644,GO:0006650,GO:0006656,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0007154,GO:0007155,GO:0007267,GO:0007268,GO:0007271,GO:0007275,GO:0007399,GO:0007416,GO:0007517,GO:0008144,GO:0008150,GO:0008152,GO:0008283,GO:0008291,GO:0008610,GO:0008654,GO:0009056,GO:0009058,GO:0009059,GO:0009611,GO:0009987,GO:0010646,GO:0010648,GO:0010817,GO:0012505,GO:0016020,GO:0016043,GO:0016787,GO:0016788,GO:0017144,GO:0017171,GO:0019538,GO:0019637,GO:0022607,GO:0022610,GO:0023051,GO:0023052,GO:0023057,GO:0030154,GO:0031012,GO:0032222,GO:0032223,GO:0032501,GO:0032502,GO:0032879,GO:0032880,GO:0033218,GO:0034641,GO:0034645,GO:0042133,GO:0042135,GO:0042136,GO:0042165,GO:0042166,GO:0042277,GO:0042445,GO:0042447,GO:0042562,GO:0042737,GO:0042802,GO:0042803,GO:0042982,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043236,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044255,GO:0044260,GO:0044420,GO:0044421,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0045017,GO:0045202,GO:0046470,GO:0046474,GO:0046483,GO:0046486,GO:0046983,GO:0048468,GO:0048471,GO:0048513,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048731,GO:0048856,GO:0048869,GO:0050708,GO:0050714,GO:0050789,GO:0050794,GO:0050804,GO:0050805,GO:0050808,GO:0050840,GO:0050896,GO:0051046,GO:0051047,GO:0051049,GO:0051050,GO:0051222,GO:0051223,GO:0052689,GO:0061061,GO:0062023,GO:0065007,GO:0065008,GO:0070201,GO:0070405,GO:0071704,GO:0071840,GO:0071944,GO:0090087,GO:0090304,GO:0090407,GO:0097164,GO:0098916,GO:0099177,GO:0099536,GO:0099537,GO:1900619,GO:1901360,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1903530,GO:1903532,GO:1904951 - ko:K03929 - - - - ko00000,ko01000 - CE10 - COesterase k59_889434_2 264730.PSPPH_5221 0.000174 50.4 COG0759@1|root,COG0759@2|Bacteria,1N6U4@1224|Proteobacteria,1SCG6@1236|Gammaproteobacteria,1Z84C@136849|Pseudomonas syringae group 1236|Gammaproteobacteria S Could be involved in insertion of integral membrane proteins into the membrane yidD GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0008565,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0016043,GO:0031224,GO:0031226,GO:0032977,GO:0033036,GO:0034613,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0061024,GO:0070727,GO:0071702,GO:0071705,GO:0071840,GO:0071944,GO:0072657,GO:0090150 - ko:K08998 - - - - ko00000 - - - Haemolytic k59_829059_1 1121035.AUCH01000001_gene1937 4.05e-50 180.0 COG1530@1|root,COG1530@2|Bacteria,1MV65@1224|Proteobacteria,2VIE5@28216|Betaproteobacteria,2KV38@206389|Rhodocyclales 206389|Rhodocyclales J Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs rne - 3.1.26.12 ko:K08300 ko03018,map03018 M00394 - - ko00000,ko00001,ko00002,ko01000,ko03009,ko03019 - - - RNase_E_G,S1 k59_151375_1 876269.ARWA01000001_gene2271 4.42e-22 90.9 COG1393@1|root,COG1393@2|Bacteria,1MZ6S@1224|Proteobacteria,2U98B@28211|Alphaproteobacteria,3NBGN@45404|Beijerinckiaceae 28211|Alphaproteobacteria P ArsC family MA20_27840 GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 1.20.4.1 ko:K00537 - - - - ko00000,ko01000 - - - ArsC k59_151375_2 1387197.AWGA01000064_gene940 1.43e-59 197.0 COG0053@1|root,COG0053@2|Bacteria,1MUDS@1224|Proteobacteria,1RNS2@1236|Gammaproteobacteria 1236|Gammaproteobacteria P Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family fieF GO:0000041,GO:0003674,GO:0005215,GO:0005381,GO:0005385,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006826,GO:0006829,GO:0006873,GO:0006875,GO:0006876,GO:0006882,GO:0008150,GO:0008324,GO:0009987,GO:0015075,GO:0015086,GO:0015093,GO:0015291,GO:0015318,GO:0015341,GO:0015562,GO:0015684,GO:0015691,GO:0016020,GO:0019725,GO:0022804,GO:0022857,GO:0022883,GO:0022890,GO:0030001,GO:0030003,GO:0034220,GO:0034755,GO:0042592,GO:0042802,GO:0044464,GO:0046583,GO:0046873,GO:0046915,GO:0046916,GO:0048878,GO:0050801,GO:0051179,GO:0051234,GO:0055065,GO:0055069,GO:0055073,GO:0055076,GO:0055080,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0070574,GO:0070838,GO:0071577,GO:0071944,GO:0072503,GO:0072507,GO:0072509,GO:0072511,GO:0098655,GO:0098660,GO:0098662,GO:0098771,GO:1903874 - ko:K13283 - - - - ko00000,ko02000 2.A.4.7.1 - - Cation_efflux,ZT_dimer k59_658105_1 1118153.MOY_01339 1.66e-06 48.5 COG0384@1|root,COG0384@2|Bacteria,1R9X4@1224|Proteobacteria,1RZ0R@1236|Gammaproteobacteria,1XJPU@135619|Oceanospirillales 135619|Oceanospirillales S PhzC PhzF - - - - - - - - - - - - PhzC-PhzF k59_658105_2 1127673.GLIP_3893 1.07e-59 194.0 COG3000@1|root,COG3000@2|Bacteria,1PK2S@1224|Proteobacteria,1S338@1236|Gammaproteobacteria 1236|Gammaproteobacteria I COG3000 Sterol desaturase - - - - - - - - - - - - FA_hydroxylase k59_151379_1 765914.ThisiDRAFT_2001 4.98e-95 296.0 COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,1RME8@1236|Gammaproteobacteria,1WX7K@135613|Chromatiales 135613|Chromatiales O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins ftsH - - ko:K03798 - M00742 - - ko00000,ko00002,ko01000,ko01002,ko03110 - - - AAA,FtsH_ext,Peptidase_M41 k59_1169534_1 1207063.P24_13223 3.26e-39 150.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2TQT0@28211|Alphaproteobacteria,2JRMJ@204441|Rhodospirillales 204441|Rhodospirillales V AcrB/AcrD/AcrF family - - - - - - - - - - - - ACR_tran k59_995894_1 349521.HCH_05171 1.54e-42 149.0 COG1191@1|root,COG1191@2|Bacteria,1MWEU@1224|Proteobacteria,1RMKJ@1236|Gammaproteobacteria,1XIKW@135619|Oceanospirillales 135619|Oceanospirillales K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor controls the expression of flagella-related genes fliA - - ko:K02405 ko02020,ko02025,ko02026,ko02040,ko05111,map02020,map02025,map02026,map02040,map05111 - - - ko00000,ko00001,ko02035,ko03021 - - - Sigma70_r2,Sigma70_r3,Sigma70_r4 k59_940578_1 1286171.EAL2_c17640 1.82e-21 96.3 COG0533@1|root,COG0533@2|Bacteria,1TQDR@1239|Firmicutes,247MG@186801|Clostridia,25V7T@186806|Eubacteriaceae 186801|Clostridia O Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction tsaD - 2.3.1.234 ko:K01409 - - R10648 RC00070,RC00416 ko00000,ko01000,ko03016 - - - Peptidase_M22 k59_432119_1 1279017.AQYJ01000029_gene3449 8.15e-93 295.0 COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,1RPCB@1236|Gammaproteobacteria,464ZC@72275|Alteromonadaceae 1236|Gammaproteobacteria O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner lon GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0004175,GO:0004176,GO:0004252,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006515,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0009056,GO:0009057,GO:0009266,GO:0009314,GO:0009408,GO:0009628,GO:0009987,GO:0010165,GO:0010212,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0017171,GO:0019538,GO:0030163,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051603,GO:0070011,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575 3.4.21.53 ko:K01338 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - AAA,LON_substr_bdg,Lon_C k59_1449032_1 471881.PROPEN_04934 2.99e-26 111.0 COG0815@1|root,COG0815@2|Bacteria,1MUBU@1224|Proteobacteria,1RM8M@1236|Gammaproteobacteria,3Z29Z@583|Proteus 1236|Gammaproteobacteria M Transfers the fatty acyl group on membrane lipoproteins lnt GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016021,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019538,GO:0031224,GO:0031226,GO:0034645,GO:0036211,GO:0042157,GO:0042158,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576 - ko:K03820 - - - - ko00000,ko01000 - GT2 iEcSMS35_1347.EcSMS35_0678,iSbBS512_1146.SbBS512_E0590 CN_hydrolase k59_151394_1 1380393.JHVP01000001_gene2363 1.45e-39 147.0 COG1506@1|root,COG1506@2|Bacteria,2H90U@201174|Actinobacteria,4EVJW@85013|Frankiales 201174|Actinobacteria E Tannase and feruloyl esterase - - - - - - - - - - - - Tannase k59_719364_2 1410634.JHVD01000011_gene2228 5.25e-13 71.2 COG1013@1|root,COG1013@2|Bacteria,2GMI5@201174|Actinobacteria,4DQ3H@85009|Propionibacteriales 201174|Actinobacteria C Thiamine pyrophosphate enzyme, C-terminal TPP binding domain korB - 1.2.7.11,1.2.7.3 ko:K00175 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C k59_1733629_1 1384054.N790_11465 2.32e-17 79.7 COG3038@1|root,COG3038@2|Bacteria,1MZ7X@1224|Proteobacteria,1S9N2@1236|Gammaproteobacteria,1XCN3@135614|Xanthomonadales 135614|Xanthomonadales C Cytochrome B561 - - - ko:K12262 - - - - ko00000 - - - Ni_hydr_CYTB k59_1733629_2 1123253.AUBD01000011_gene2074 1.43e-57 186.0 COG2353@1|root,COG2353@2|Bacteria,1R9XD@1224|Proteobacteria,1T042@1236|Gammaproteobacteria,1X4RF@135614|Xanthomonadales 135614|Xanthomonadales S Belongs to the UPF0312 family - - - - - - - - - - - - YceI k59_97013_1 565045.NOR51B_122 5.05e-86 265.0 COG4638@1|root,COG4638@2|Bacteria,1MWXW@1224|Proteobacteria,1RQ0P@1236|Gammaproteobacteria,1JA4R@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P COG4638 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit - - - - - - - - - - - - Rieske,Ring_hydroxyl_A k59_1225577_2 436308.Nmar_1245 5.36e-69 227.0 COG0419@1|root,COG1122@1|root,arCOG00202@2157|Archaea,arCOG00368@2157|Archaea,41S9P@651137|Thaumarchaeota 651137|Thaumarchaeota LP AAA domain - - - ko:K03546 - - - - ko00000,ko03400 - - - AAA_15 k59_1794734_1 56780.SYN_01012 2.25e-08 56.6 COG0594@1|root,COG0594@2|Bacteria,1NGQJ@1224|Proteobacteria,42VBC@68525|delta/epsilon subdivisions,2WRF0@28221|Deltaproteobacteria,2MSHR@213462|Syntrophobacterales 28221|Deltaproteobacteria J RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme rnpA - 3.1.26.5 ko:K03536 - - - - ko00000,ko01000,ko03016 - - - Ribonuclease_P k59_1794734_2 1123288.SOV_2c05900 6.47e-20 82.4 COG0759@1|root,COG0759@2|Bacteria,1VEIG@1239|Firmicutes,4H5K3@909932|Negativicutes 909932|Negativicutes S Could be involved in insertion of integral membrane proteins into the membrane - - - ko:K08998 - - - - ko00000 - - - Haemolytic k59_1794734_3 398767.Glov_3642 3.72e-12 76.3 COG0706@1|root,COG0706@2|Bacteria,1MV5M@1224|Proteobacteria,42MS8@68525|delta/epsilon subdivisions,2WJB6@28221|Deltaproteobacteria 28221|Deltaproteobacteria U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins yidC - - ko:K03217 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044,ko03029 2.A.9 - - 60KD_IMP,YidC_periplas k59_1742346_1 633149.Bresu_0849 1.69e-78 261.0 COG0793@1|root,COG4946@1|root,COG0793@2|Bacteria,COG4946@2|Bacteria,1MX41@1224|Proteobacteria,2U26V@28211|Alphaproteobacteria 28211|Alphaproteobacteria M Tricorn protease homolog - - 3.4.21.102 ko:K03797,ko:K08676 - - - - ko00000,ko01000,ko01002 - - - PD40,PDZ_2,Peptidase_S41,Tricorn_C1,Tricorn_PDZ k59_1407423_1 882.DVU_3246 2.06e-45 164.0 COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,42MRU@68525|delta/epsilon subdivisions,2WIQX@28221|Deltaproteobacteria,2MA64@213115|Desulfovibrionales 28221|Deltaproteobacteria M TIGRFAM RND efflux system, outer membrane lipoprotein, NodT - - - - - - - - - - - - OEP k59_441443_1 1440052.EAKF1_ch2493 3.89e-06 47.4 COG2177@1|root,COG2177@2|Bacteria,1MU65@1224|Proteobacteria,1RYBV@1236|Gammaproteobacteria,3XP6A@561|Escherichia 1236|Gammaproteobacteria D Part of the ABC transporter FtsEX involved in cellular division ftsX GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0009274,GO:0009276,GO:0009987,GO:0016020,GO:0016021,GO:0030312,GO:0030313,GO:0031224,GO:0031975,GO:0032153,GO:0044425,GO:0044464,GO:0051301,GO:0071944 - ko:K09811 ko02010,map02010 M00256 - - ko00000,ko00001,ko00002,ko02000,ko03036 3.A.1.140 - - FtsX k59_441443_2 316407.85676580 3.71e-126 360.0 COG2884@1|root,COG2884@2|Bacteria,1MVQ4@1224|Proteobacteria,1RMZA@1236|Gammaproteobacteria,3XP97@561|Escherichia 1236|Gammaproteobacteria D Part of the ABC transporter FtsEX involved in cellular division. Important for assembly or stability of the septal ring ftsE GO:0000166,GO:0003674,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0008144,GO:0008150,GO:0009898,GO:0009987,GO:0016020,GO:0017076,GO:0019897,GO:0019898,GO:0030554,GO:0031234,GO:0032153,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042221,GO:0043167,GO:0043168,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0046677,GO:0050896,GO:0051301,GO:0071944,GO:0097159,GO:0097367,GO:0098552,GO:0098562,GO:1901265,GO:1901363 - ko:K09812 ko02010,map02010 M00256 - - ko00000,ko00001,ko00002,ko02000,ko03036 3.A.1.140 - - ABC_tran k59_1685283_1 1336803.PHEL49_0611 4.04e-78 256.0 COG5549@1|root,COG5549@2|Bacteria,4NEA0@976|Bacteroidetes,1HWUW@117743|Flavobacteriia 976|Bacteroidetes O Domain of unknown function (DUF5117) - - - - - - - - - - - - DUF4953,DUF5117,DUF5118 k59_1685290_1 649638.Trad_0781 2.63e-32 124.0 COG1972@1|root,COG1972@2|Bacteria,1WKZR@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus U Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family - - - ko:K03317 - - - - ko00000 2.A.41 - - Gate,Nucleos_tra2_C,Nucleos_tra2_N k59_1630035_1 1121912.AUHD01000027_gene290 8.21e-06 50.1 COG1028@1|root,COG1028@2|Bacteria,4NGQY@976|Bacteroidetes,1HZ7N@117743|Flavobacteriia 976|Bacteroidetes IQ short-chain dehydrogenase - - - - - - - - - - - - adh_short,adh_short_C2 k59_1630035_2 426117.M446_1296 4.27e-38 129.0 COG1359@1|root,COG1359@2|Bacteria,1N0P9@1224|Proteobacteria,2UCIC@28211|Alphaproteobacteria,1JYC9@119045|Methylobacteriaceae 28211|Alphaproteobacteria S Antibiotic biosynthesis monooxygenase - - - - - - - - - - - - ABM k59_1742351_1 1122613.ATUP01000002_gene2643 3.82e-31 126.0 COG1629@1|root,COG4771@2|Bacteria,1MWKN@1224|Proteobacteria,2U10R@28211|Alphaproteobacteria,43W4Y@69657|Hyphomonadaceae 28211|Alphaproteobacteria P TonB dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_667738_1 439235.Dalk_1576 2.62e-52 174.0 COG0745@1|root,COG0745@2|Bacteria,1MVCB@1224|Proteobacteria,42UVV@68525|delta/epsilon subdivisions,2WUTB@28221|Deltaproteobacteria 28221|Deltaproteobacteria K response - - - ko:K02483 - - - - ko00000,ko02022 - - - Response_reg,Trans_reg_C k59_1519723_1 1125863.JAFN01000001_gene3225 3.6e-140 405.0 COG0683@1|root,COG0683@2|Bacteria,1MU8V@1224|Proteobacteria,42NVW@68525|delta/epsilon subdivisions,2WMR9@28221|Deltaproteobacteria 28221|Deltaproteobacteria E Periplasmic binding protein domain - - - ko:K01999,ko:K11959 ko02010,ko02024,map02010,map02024 M00237,M00323 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4,3.A.1.4.4,3.A.1.4.5 - - Peripla_BP_5 k59_1458286_1 765912.Thimo_1481 2.36e-55 184.0 COG1651@1|root,COG1651@2|Bacteria,1RD39@1224|Proteobacteria,1S3U8@1236|Gammaproteobacteria,1WXSE@135613|Chromatiales 135613|Chromatiales O Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process - - 5.3.4.1 ko:K03981 - - - - ko00000,ko01000,ko02044,ko03110 3.A.7.11.1 - - DsbC_N,Thioredoxin_2 k59_1344848_1 1122137.AQXF01000003_gene2036 3.04e-43 159.0 COG0642@1|root,COG2205@2|Bacteria,1NUD7@1224|Proteobacteria,2URRQ@28211|Alphaproteobacteria 28211|Alphaproteobacteria T 7TM diverse intracellular signalling - - - - - - - - - - - - 7TMR-DISM_7TM,HATPase_c,HisKA k59_898808_1 377629.TERTU_4075 1.75e-57 185.0 COG1238@1|root,COG1238@2|Bacteria,1MWED@1224|Proteobacteria,1S034@1236|Gammaproteobacteria,2PNME@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria S SNARE associated Golgi protein - - - - - - - - - - - - SNARE_assoc k59_1344856_1 1123392.AQWL01000004_gene2603 5.73e-83 254.0 COG0668@1|root,COG0668@2|Bacteria,1N596@1224|Proteobacteria,2VQ9J@28216|Betaproteobacteria,1KSDQ@119069|Hydrogenophilales 119069|Hydrogenophilales M Conserved TM helix - - - - - - - - - - - - MS_channel,TM_helix k59_1344864_1 1116472.MGMO_14c00180 1.82e-32 123.0 COG1748@1|root,COG1748@2|Bacteria,1MY1G@1224|Proteobacteria,1RRUZ@1236|Gammaproteobacteria 1236|Gammaproteobacteria E Dehydrogenase lysDH - - - - - - - - - - - Sacchrp_dh_C,Sacchrp_dh_NADP k59_1344864_2 1453498.LG45_12590 0.000126 45.4 COG1012@1|root,COG1012@2|Bacteria,4NFPJ@976|Bacteroidetes,1HX3I@117743|Flavobacteriia,2NUBG@237|Flavobacterium 976|Bacteroidetes C Belongs to the aldehyde dehydrogenase family pcd - 1.2.1.3 ko:K00128 ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130 M00135 R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146 RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_1234058_1 1117318.PRUB_17702 2.14e-33 125.0 COG0454@1|root,COG0454@2|Bacteria,1MVVG@1224|Proteobacteria,1RQ5J@1236|Gammaproteobacteria,2Q1AZ@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria K COG0454 Histone acetyltransferase HPA2 and related acetyltransferases - - - - - - - - - - - - Acetyltransf_1 k59_1234058_2 158500.BV97_02270 9.11e-24 95.5 COG4262@1|root,COG4262@2|Bacteria,1P1G3@1224|Proteobacteria,2TQSR@28211|Alphaproteobacteria,2K07Q@204457|Sphingomonadales 204457|Sphingomonadales S Spermidine synthase - - - - - - - - - - - - Spermine_synth k59_1178251_1 525260.HMPREF0276_2160 3.82e-37 135.0 COG0284@1|root,COG0284@2|Bacteria,2GKWK@201174|Actinobacteria,22K1J@1653|Corynebacteriaceae 201174|Actinobacteria F Belongs to the OMP decarboxylase family. Type 2 subfamily pyrF - 4.1.1.23 ko:K01591 ko00240,ko01100,map00240,map01100 M00051 R00965 RC00409 ko00000,ko00001,ko00002,ko01000 - - - OMPdecase k59_779030_1 1280952.HJA_13220 4.4e-107 328.0 COG0493@1|root,COG1143@1|root,COG0493@2|Bacteria,COG1143@2|Bacteria,1MU2H@1224|Proteobacteria,2TQK5@28211|Alphaproteobacteria 28211|Alphaproteobacteria C COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductases MA20_01050 - 1.17.1.10 ko:K15022 ko00680,ko00720,ko01120,ko01200,map00680,map00720,map01120,map01200 M00377 R00134 RC02796 ko00000,ko00001,ko00002,ko01000 - - - Fer4_20,Fer4_7,NADH_4Fe-4S,Pyr_redox_2,Pyr_redox_3 k59_1794768_1 1122135.KB893139_gene1352 1.09e-72 233.0 COG0069@1|root,COG0069@2|Bacteria,1MU7B@1224|Proteobacteria,2TREH@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Belongs to the glutamate synthase family - - - - - - - - - - - - Glu_synthase k59_1407471_1 1122137.AQXF01000007_gene3532 2.69e-65 208.0 COG0136@1|root,COG0136@2|Bacteria,1MUHG@1224|Proteobacteria,2TSRD@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate asd - 1.2.1.11 ko:K00133 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00017,M00018,M00033,M00525,M00526,M00527 R02291 RC00684 ko00000,ko00001,ko00002,ko01000 - - - Semialdhyde_dh,Semialdhyde_dhC k59_1407471_2 1122137.AQXF01000007_gene3533 2.42e-79 246.0 COG0473@1|root,COG0473@2|Bacteria,1MUH4@1224|Proteobacteria,2TQKG@28211|Alphaproteobacteria 28211|Alphaproteobacteria CE Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate leuB GO:0003674,GO:0003824,GO:0003862,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.85 ko:K00052 ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230 M00432,M00535 R00994,R04426,R10052 RC00084,RC00417,RC03036 br01601,ko00000,ko00001,ko00002,ko01000 - - - Iso_dh k59_390617_1 391615.ABSJ01000039_gene1827 6.27e-79 251.0 COG3071@1|root,COG3071@2|Bacteria,1MU7A@1224|Proteobacteria,1RMRG@1236|Gammaproteobacteria,1J5RD@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H enzyme of heme biosynthesis hemY GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K02498 - - - - ko00000 - - - HemY_N,TPR_2 k59_615596_1 1869.MB27_18265 3.63e-17 82.0 COG0593@1|root,COG0593@2|Bacteria,2GJKI@201174|Actinobacteria,4DAG5@85008|Micromonosporales 201174|Actinobacteria L it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids dnaA GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003688,GO:0003690,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006172,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009133,GO:0009135,GO:0009136,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009179,GO:0009180,GO:0009185,GO:0009188,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016311,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030312,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046031,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090304,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990837 - ko:K02313 ko02020,ko04112,map02020,map04112 - - - ko00000,ko00001,ko03032,ko03036 - - - Bac_DnaA,Bac_DnaA_C k59_615596_2 1123392.AQWL01000007_gene902 1.42e-08 57.0 COG0564@1|root,COG0564@2|Bacteria,1MVDX@1224|Proteobacteria,2VI51@28216|Betaproteobacteria,1KRAR@119069|Hydrogenophilales 119069|Hydrogenophilales J S4 RNA-binding domain - - 5.4.99.24 ko:K06179 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2,S4 k59_1458349_1 1167006.UWK_00878 1.1e-61 204.0 COG2834@1|root,COG2834@2|Bacteria,1MXW0@1224|Proteobacteria,42QPE@68525|delta/epsilon subdivisions,2WN39@28221|Deltaproteobacteria,2MJHS@213118|Desulfobacterales 28221|Deltaproteobacteria M Protein of unknown function (DUF1329) - - - - - - - - - - - - LolA_like k59_1005336_1 316067.Geob_1534 3.02e-20 95.1 COG2199@1|root,COG2203@1|root,COG2203@2|Bacteria,COG3706@2|Bacteria,1MZV7@1224|Proteobacteria,43AIQ@68525|delta/epsilon subdivisions,2X5YZ@28221|Deltaproteobacteria 28221|Deltaproteobacteria T Sensor diguanylate cyclase, GAF domain-containing - - - - - - - - - - - - GAF_2,GGDEF,PocR k59_106179_1 85643.Tmz1t_1697 1.72e-35 124.0 COG1734@1|root,COG1734@2|Bacteria,1RD08@1224|Proteobacteria,2VRPJ@28216|Betaproteobacteria,2KW6P@206389|Rhodocyclales 206389|Rhodocyclales T Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters dksA - - ko:K06204 ko02026,map02026 - - - ko00000,ko00001,ko03000,ko03009,ko03021 - - - zf-dskA_traR k59_838517_1 1183438.GKIL_2426 9.87e-15 74.3 COG1502@1|root,COG1502@2|Bacteria,1G35F@1117|Cyanobacteria 1117|Cyanobacteria I Phosphatidylserine phosphatidylglycerophosphate cardiolipin synthase - - - ko:K06131 ko00564,ko01100,map00564,map01100 - R07390 RC00017 ko00000,ko00001,ko01000 - - - PLDc_2 k59_441515_1 1122137.AQXF01000001_gene3089 6.51e-313 877.0 COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,2TRJF@28211|Alphaproteobacteria 28211|Alphaproteobacteria L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity polA GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008408,GO:0008409,GO:0009058,GO:0009059,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901362,GO:1901363,GO:1901576 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1 k59_217791_1 47763.JNZA01000009_gene5523 6.19e-09 61.2 COG1277@1|root,COG1277@2|Bacteria,2GK3E@201174|Actinobacteria 201174|Actinobacteria S ABC-2 family transporter protein - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_2,ABC2_membrane_4 k59_1630091_1 215803.DB30_2624 7.09e-08 59.3 COG2124@1|root,COG2124@2|Bacteria,1MY5H@1224|Proteobacteria,437S5@68525|delta/epsilon subdivisions,2X314@28221|Deltaproteobacteria,2YTXI@29|Myxococcales 28221|Deltaproteobacteria C Cytochrome P450 - - - - - - - - - - - - p450 k59_1288699_1 1236542.BALM01000011_gene3913 1.11e-47 171.0 COG0369@1|root,COG0369@2|Bacteria,1QUAH@1224|Proteobacteria,1T1RJ@1236|Gammaproteobacteria,2Q8RU@267890|Shewanellaceae 1236|Gammaproteobacteria C Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component cysJ GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0008150,GO:0008152,GO:0009337,GO:0010181,GO:0016491,GO:0016645,GO:0016646,GO:0032553,GO:0032991,GO:0036094,GO:0042602,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0048037,GO:0050660,GO:0050661,GO:0050662,GO:0055114,GO:0070401,GO:0097159,GO:0097367,GO:1901265,GO:1901363 1.8.1.2 ko:K00380 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00176 R00858 RC00065 ko00000,ko00001,ko00002,ko01000 - - iECO26_1355.ECO26_3835,iECSE_1348.ECSE_3020,iECW_1372.ECW_m2972,iEKO11_1354.EKO11_1004,iEcE24377_1341.EcE24377A_3066,iEcolC_1368.EcolC_0948,iWFL_1372.ECW_m2972 FAD_binding_1,Flavodoxin_1,NAD_binding_1 k59_106192_1 1454004.AW11_01686 1.29e-19 90.1 COG1295@1|root,COG1959@1|root,COG1295@2|Bacteria,COG1959@2|Bacteria,1QICW@1224|Proteobacteria,2VPV7@28216|Betaproteobacteria 28216|Betaproteobacteria K Virulence factor BrkB - - - ko:K07058 - - - - ko00000 - - - Virul_fac_BrkB k59_106192_2 1279019.ARQK01000038_gene1910 6.94e-21 89.4 COG0152@1|root,COG0152@2|Bacteria,1MUR9@1224|Proteobacteria,1RNNY@1236|Gammaproteobacteria,1WVZH@135613|Chromatiales 135613|Chromatiales F SAICAR synthetase purC - 6.3.2.6 ko:K01923 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04591 RC00064,RC00162 ko00000,ko00001,ko00002,ko01000 - - - SAICAR_synt k59_333489_1 118161.KB235924_gene6574 2.24e-82 259.0 2DMFF@1|root,32R5F@2|Bacteria,1GAQC@1117|Cyanobacteria 1117|Cyanobacteria S IMG reference gene - - - - - - - - - - - - - k59_50238_1 1122137.AQXF01000002_gene452 3.34e-132 385.0 COG2200@1|root,COG2200@2|Bacteria,1MVJY@1224|Proteobacteria,2U1SU@28211|Alphaproteobacteria 28211|Alphaproteobacteria T COG2203 FOG GAF domain - - - - - - - - - - - - EAL,GAF,GAF_2 k59_1794814_1 1197477.IA57_07240 4.83e-50 166.0 COG1073@1|root,COG1073@2|Bacteria,4NGCE@976|Bacteroidetes,1HYN3@117743|Flavobacteriia 976|Bacteroidetes S Serine aminopeptidase, S33 - - - ko:K06889 - - - - ko00000 - - - Hydrolase_4 k59_1119409_1 269799.Gmet_0924 5.85e-79 244.0 COG1209@1|root,COG1209@2|Bacteria,1MU0X@1224|Proteobacteria,42MTN@68525|delta/epsilon subdivisions,2WJAI@28221|Deltaproteobacteria,43S7Y@69541|Desulfuromonadales 28221|Deltaproteobacteria H Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis rmlA - 2.7.7.24 ko:K00973 ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130 M00793 R02328 RC00002 ko00000,ko00001,ko00002,ko01000 - - - NTP_transferase k59_1119409_2 290315.Clim_0505 9.8e-21 89.4 COG0824@1|root,COG0824@2|Bacteria 2|Bacteria IQ Thioesterase - - - ko:K07107 - - - - ko00000,ko01000 - - - Acyl-ACP_TE k59_667796_2 1458357.BG58_12515 3.61e-76 239.0 COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2VHB0@28216|Betaproteobacteria,1K17R@119060|Burkholderiaceae 28216|Betaproteobacteria C PFAM L-carnitine dehydratase bile acid-inducible protein F - - 2.8.3.16 ko:K07749 - - - - ko00000,ko01000 - - - CoA_transf_3 k59_1005379_1 436308.Nmar_1783 1.44e-101 300.0 COG2112@1|root,arCOG01182@2157|Archaea,41SJV@651137|Thaumarchaeota 651137|Thaumarchaeota T Ser thr protein kinase - - - ko:K07176 - - - - ko00000 - - - RIO1 k59_1288716_1 936589.HMPREF1521_1087 3.25e-20 95.1 COG0841@1|root,COG0841@2|Bacteria,1TQ03@1239|Firmicutes,4H2FN@909932|Negativicutes 909932|Negativicutes V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family czcA - - ko:K18303 - M00642 - - ko00000,ko00002,ko01504,ko02000 2.A.6.2.17 - - ACR_tran k59_1178297_1 436308.Nmar_1513 2.84e-21 88.2 COG1325@1|root,arCOG01042@2157|Archaea,41SWK@651137|Thaumarchaeota 651137|Thaumarchaeota J RNA binding - - - ko:K07581 - - - - ko00000 - - - RNA_binding k59_106217_1 436308.Nmar_0883 1.55e-20 84.3 COG0537@1|root,arCOG00419@2157|Archaea,41SNV@651137|Thaumarchaeota 651137|Thaumarchaeota F HIT domain - - - ko:K02503 - - - - ko00000,ko04147 - - - HIT k59_552574_1 1122137.AQXF01000005_gene1218 5.32e-100 307.0 COG2200@1|root,COG2200@2|Bacteria,1N299@1224|Proteobacteria,2TT4R@28211|Alphaproteobacteria 28211|Alphaproteobacteria T EAL domain yfgF - - - - - - - - - - - EAL k59_615628_1 999541.bgla_1g26500 4.84e-87 265.0 COG0825@1|root,COG0825@2|Bacteria,1MURN@1224|Proteobacteria,2VHS0@28216|Betaproteobacteria,1K130@119060|Burkholderiaceae 28216|Betaproteobacteria I Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA accA - 2.1.3.15,6.4.1.2 ko:K01962 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04386 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 - - - ACCA k59_106226_2 1442599.JAAN01000026_gene1306 1.56e-37 142.0 COG3590@1|root,COG3590@2|Bacteria,1MVNQ@1224|Proteobacteria,1RNNA@1236|Gammaproteobacteria,1X4B6@135614|Xanthomonadales 135614|Xanthomonadales O peptidase - - - ko:K07386 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M13,Peptidase_M13_N k59_615632_2 644801.Psest_4375 5.26e-24 93.6 COG0759@1|root,COG0759@2|Bacteria,1N6U4@1224|Proteobacteria,1SCG6@1236|Gammaproteobacteria,1Z36Q@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria S Could be involved in insertion of integral membrane proteins into the membrane yidD GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0008565,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0016043,GO:0031224,GO:0031226,GO:0032977,GO:0033036,GO:0034613,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0061024,GO:0070727,GO:0071702,GO:0071705,GO:0071840,GO:0071944,GO:0072657,GO:0090150 - ko:K08998 - - - - ko00000 - - - Haemolytic k59_615632_3 1301098.PKB_5823 4.48e-13 66.6 COG0594@1|root,COG0594@2|Bacteria,1MZQE@1224|Proteobacteria,1S90M@1236|Gammaproteobacteria 1236|Gammaproteobacteria J RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme rnpA GO:0000966,GO:0001682,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004526,GO:0004540,GO:0004549,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005655,GO:0005730,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0030677,GO:0030681,GO:0031974,GO:0031981,GO:0032991,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0044237,GO:0044238,GO:0044422,GO:0044424,GO:0044428,GO:0044446,GO:0044452,GO:0044464,GO:0046483,GO:0070013,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0099116,GO:0140098,GO:0140101,GO:1901360,GO:1902494,GO:1902555,GO:1905348,GO:1990904 3.1.26.5 ko:K03536 - - - - ko00000,ko01000,ko03016 - - - Ribonuclease_P k59_1794828_1 1122137.AQXF01000001_gene3054 7.09e-15 74.7 COG3437@1|root,COG3437@2|Bacteria,1R0ZH@1224|Proteobacteria 1224|Proteobacteria KT HD domain - - - - - - - - - - - - HD_5,PAS_4 k59_1794828_2 1122137.AQXF01000001_gene3053 1.48e-45 154.0 COG3672@1|root,COG3672@2|Bacteria,1RDQS@1224|Proteobacteria,2TTZT@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Bacterial transglutaminase-like cysteine proteinase BTLCP - - - - - - - - - - - - Peptidase_C93 k59_552583_1 883078.HMPREF9695_00297 6.03e-18 88.6 COG1196@1|root,COG1196@2|Bacteria,1MUAQ@1224|Proteobacteria,2TRQG@28211|Alphaproteobacteria,3JUPU@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria D Required for chromosome condensation and partitioning smc - - ko:K03529 - - - - ko00000,ko03036 - - - SMC_N k59_838551_1 9986.ENSOCUP00000026973 2.41e-07 58.5 KOG1584@1|root,KOG1584@2759|Eukaryota,39XXS@33154|Opisthokonta,3BAJV@33208|Metazoa,3CSHX@33213|Bilateria,48878@7711|Chordata,48W0K@7742|Vertebrata,3JARM@40674|Mammalia 33208|Metazoa S Sulfotransferase family cytosolic 2B member 1 SULT2B1 GO:0000103,GO:0003674,GO:0003676,GO:0003824,GO:0004027,GO:0005488,GO:0005496,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006066,GO:0006082,GO:0006139,GO:0006163,GO:0006629,GO:0006725,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008146,GO:0008150,GO:0008152,GO:0008202,GO:0008203,GO:0008285,GO:0008289,GO:0009117,GO:0009150,GO:0009259,GO:0009987,GO:0015485,GO:0016125,GO:0016740,GO:0016782,GO:0019637,GO:0019693,GO:0030856,GO:0030858,GO:0032934,GO:0033865,GO:0033875,GO:0034032,GO:0034035,GO:0034641,GO:0036094,GO:0042127,GO:0042562,GO:0043178,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045595,GO:0045597,GO:0045604,GO:0045606,GO:0045682,GO:0045684,GO:0046483,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050294,GO:0050427,GO:0050789,GO:0050793,GO:0050794,GO:0051094,GO:0051239,GO:0055086,GO:0065007,GO:0071704,GO:0072521,GO:0097159,GO:1901135,GO:1901360,GO:1901363,GO:1901564,GO:1901615,GO:1902652,GO:1990239,GO:2000026 2.8.2.2 ko:K01015 ko00140,map00140 - R00629,R03405,R08977,R08978 RC00007,RC00231,RC00341 ko00000,ko00001,ko01000 - - - Sulfotransfer_1 k59_779081_1 1248916.ANFY01000005_gene2858 5.54e-53 184.0 COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2TRUI@28211|Alphaproteobacteria,2K6JI@204457|Sphingomonadales 204457|Sphingomonadales T Adenylate cyclase - - - - - - - - - - - - TIR_2,TPR_8,Trans_reg_C k59_950694_2 1122137.AQXF01000003_gene2235 3.95e-08 53.1 COG0745@1|root,COG0745@2|Bacteria,1N0YI@1224|Proteobacteria,2TSV8@28211|Alphaproteobacteria 28211|Alphaproteobacteria T Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain feuP - - ko:K02483 - - - - ko00000,ko02022 - - - Response_reg,Trans_reg_C k59_161818_1 493475.GARC_4493 2.97e-28 113.0 COG1589@1|root,COG1589@2|Bacteria,1N0T7@1224|Proteobacteria,1S9FJ@1236|Gammaproteobacteria,464U9@72275|Alteromonadaceae 1236|Gammaproteobacteria D Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly ftsQ GO:0000003,GO:0000278,GO:0000281,GO:0000910,GO:0000917,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0007049,GO:0008150,GO:0009987,GO:0016020,GO:0016021,GO:0016043,GO:0019954,GO:0022402,GO:0022414,GO:0022607,GO:0031224,GO:0031226,GO:0032153,GO:0032505,GO:0032506,GO:0042802,GO:0043093,GO:0044085,GO:0044425,GO:0044459,GO:0044464,GO:0051301,GO:0061640,GO:0071840,GO:0071944,GO:0090529,GO:1902410,GO:1903047 - ko:K03589 ko04112,map04112 - - - ko00000,ko00001,ko03036 - - - FtsQ,POTRA_1 k59_1631267_1 644107.SL1157_1377 8.46e-26 99.4 COG3795@1|root,COG3795@2|Bacteria,1RJJG@1224|Proteobacteria,2UCR2@28211|Alphaproteobacteria,4NCMU@97050|Ruegeria 28211|Alphaproteobacteria S YCII-related domain - - - - - - - - - - - - YCII k59_334580_1 748280.NH8B_2170 5.38e-10 60.8 COG1024@1|root,COG1024@2|Bacteria,1MWZC@1224|Proteobacteria,2VJVA@28216|Betaproteobacteria,2KR3Q@206351|Neisseriales 206351|Neisseriales I Enoyl-CoA hydratase/isomerase - - 4.2.1.17 ko:K01715 ko00650,ko01200,map00650,map01200 - R03026 RC00831 ko00000,ko00001,ko01000 - - - ECH_1 k59_1408663_1 1250005.PHEL85_1966 1.02e-112 336.0 COG1139@1|root,COG1139@2|Bacteria,4NEBT@976|Bacteroidetes,1HZDG@117743|Flavobacteriia 976|Bacteroidetes C 4Fe-4S ferredoxin - - - ko:K18929 - - - - ko00000 - - - DUF3390,Fer4_8,LUD_dom k59_334586_1 1121033.AUCF01000017_gene3777 4.18e-34 125.0 COG3090@1|root,COG3090@2|Bacteria,1N7J6@1224|Proteobacteria,2UDKU@28211|Alphaproteobacteria,2JTRZ@204441|Rhodospirillales 204441|Rhodospirillales G Tripartite ATP-independent periplasmic transporters, DctQ component - - - - - - - - - - - - DctQ k59_1578516_1 247633.GP2143_17331 3.89e-77 253.0 COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,1RN40@1236|Gammaproteobacteria,1J9VK@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C COG1529 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL CutL homologs yagR GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016903,GO:0030151,GO:0033554,GO:0042597,GO:0043167,GO:0043169,GO:0044464,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0055114 1.17.1.4 ko:K11177 ko00230,ko01100,ko01120,map00230,map01100,map01120 M00546 R01768,R02103 RC00143 ko00000,ko00001,ko00002,ko01000 - - - Ald_Xan_dh_C,Ald_Xan_dh_C2 k59_668952_1 550540.Fbal_1882 2.91e-69 233.0 COG1033@1|root,COG1033@2|Bacteria,1MUE1@1224|Proteobacteria,1RN01@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Exporters of the RND superfamily - - - ko:K07003 - - - - ko00000 - - - MMPL k59_1345999_1 1123261.AXDW01000025_gene1759 1.52e-11 68.9 COG3437@1|root,COG3437@2|Bacteria,1P1A3@1224|Proteobacteria,1S1WE@1236|Gammaproteobacteria,1X9QR@135614|Xanthomonadales 135614|Xanthomonadales KT cheY-homologous receiver domain - - - - - - - - - - - - Response_reg k59_497963_1 1219035.NT2_04_02130 9.03e-37 150.0 COG4774@1|root,COG4774@2|Bacteria,1NMCN@1224|Proteobacteria,2TW4E@28211|Alphaproteobacteria,2K2TV@204457|Sphingomonadales 204457|Sphingomonadales P TonB dependent receptor - - - - - - - - - - - - Plug,TonB_dep_Rec k59_1006415_1 1415778.JQMM01000001_gene2132 1.38e-95 290.0 COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,1RN5B@1236|Gammaproteobacteria,1J5DQ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E COG0436 Aspartate tyrosine aromatic aminotransferase alaA GO:0003674,GO:0003824,GO:0004021,GO:0005488,GO:0006082,GO:0006090,GO:0006520,GO:0006522,GO:0006523,GO:0006807,GO:0006950,GO:0006974,GO:0008144,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009058,GO:0009078,GO:0009079,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0019272,GO:0019752,GO:0019842,GO:0030170,GO:0030632,GO:0032787,GO:0033554,GO:0036094,GO:0042221,GO:0042851,GO:0042852,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046144,GO:0046145,GO:0046394,GO:0046416,GO:0046436,GO:0046437,GO:0046677,GO:0047635,GO:0048037,GO:0050662,GO:0050896,GO:0051716,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.6.1.2,2.6.1.66 ko:K14260 ko00220,ko00250,ko00290,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00290,map01100,map01110,map01130,map01210,map01230 - R00258,R01215 RC00006,RC00008,RC00036 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_1_2 k59_553677_1 394221.Mmar10_1457 1.44e-70 241.0 COG5616@1|root,COG5616@2|Bacteria,1NSKC@1224|Proteobacteria,2TWZ1@28211|Alphaproteobacteria,44159@69657|Hyphomonadaceae 28211|Alphaproteobacteria K cAMP biosynthetic process - - - - - - - - - - - - Guanylate_cyc,Trans_reg_C k59_1520910_1 880072.Desac_2284 5.75e-40 145.0 COG0196@1|root,COG0196@2|Bacteria,1MV9I@1224|Proteobacteria,42MV7@68525|delta/epsilon subdivisions,2WJTU@28221|Deltaproteobacteria,2MQCP@213462|Syntrophobacterales 28221|Deltaproteobacteria H Belongs to the ribF family ribF - 2.7.1.26,2.7.7.2 ko:K11753 ko00740,ko01100,ko01110,map00740,map01100,map01110 M00125 R00161,R00549 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - FAD_syn,Flavokinase k59_1179422_1 713586.KB900536_gene91 1.23e-68 228.0 COG0493@1|root,COG1143@1|root,COG0493@2|Bacteria,COG1143@2|Bacteria,1MU2H@1224|Proteobacteria,1RREP@1236|Gammaproteobacteria,1WWDT@135613|Chromatiales 135613|Chromatiales C PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase - - - - - - - - - - - - Fer4_20,Fer4_7,Pyr_redox_2 k59_1289863_1 998674.ATTE01000001_gene2257 1.74e-84 257.0 COG1043@1|root,COG1043@2|Bacteria,1MUHQ@1224|Proteobacteria,1RPHB@1236|Gammaproteobacteria,4605I@72273|Thiotrichales 72273|Thiotrichales M Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell lpxA - 2.3.1.129 ko:K00677 ko00540,ko01100,ko01503,map00540,map01100,map01503 M00060 R04567 RC00039,RC00055 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Acetyltransf_11,Hexapep k59_1631293_2 926550.CLDAP_30520 2.49e-18 82.4 COG2197@1|root,COG2197@2|Bacteria,2G8WD@200795|Chloroflexi 200795|Chloroflexi K helix_turn_helix, Lux Regulon - - - - - - - - - - - - GerE,Response_reg k59_277035_1 523791.Kkor_0637 2.54e-95 296.0 COG1530@1|root,COG1530@2|Bacteria,1MV65@1224|Proteobacteria,1RMIW@1236|Gammaproteobacteria,1XI2S@135619|Oceanospirillales 135619|Oceanospirillales J Involved in the processing of the 5'end of 16S rRNA - - - ko:K08301 - - - - ko00000,ko01000,ko03009,ko03019 - - - RNase_E_G,S1 k59_740949_2 1218352.B597_017140 1.06e-33 126.0 COG0714@1|root,COG0714@2|Bacteria,1MUFN@1224|Proteobacteria,1RN5G@1236|Gammaproteobacteria,1Z103@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria S COG0714 MoxR-like ATPases - - - ko:K03924 - - - - ko00000,ko01000 - - - AAA_3 k59_1531947_1 1140.Synpcc7942_1667 5.62e-25 107.0 COG0771@1|root,COG0771@2|Bacteria,1G16M@1117|Cyanobacteria,1GYZX@1129|Synechococcus 1117|Cyanobacteria M Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) murD - 6.3.2.9 ko:K01925 ko00471,ko00550,ko01100,map00471,map00550,map01100 - R02783 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase_C,Mur_ligase_M k59_1587889_1 1229909.NSED_07400 2.73e-12 65.5 COG1226@1|root,arCOG01964@2157|Archaea 2157|Archaea P PFAM Ion transport - GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0042802,GO:0044464,GO:0071944 - ko:K10716 - - - - ko00000,ko02000 1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6 - - Ion_trans,Ion_trans_2 k59_1587889_2 1229909.NSED_07405 7.91e-91 282.0 COG0598@1|root,arCOG02265@2157|Archaea 2157|Archaea P Mediates influx of magnesium ions corA - - ko:K03284 - - - - ko00000,ko02000 1.A.35.1,1.A.35.3 - - CorA k59_1249156_2 511.JT27_19185 8.4e-26 108.0 COG4603@1|root,COG4603@2|Bacteria,1MX6V@1224|Proteobacteria,2VH2R@28216|Betaproteobacteria,3T8UU@506|Alcaligenaceae 28216|Betaproteobacteria U Branched-chain amino acid transport system / permease component - - - ko:K02057 - M00221 - - ko00000,ko00002,ko02000 3.A.1.2 - - BPD_transp_2 k59_1418461_1 768066.HELO_1264 9.81e-60 201.0 COG0477@1|root,COG2814@2|Bacteria,1MVSH@1224|Proteobacteria,1RN70@1236|Gammaproteobacteria,1XHXW@135619|Oceanospirillales 135619|Oceanospirillales EGP Major facilitator superfamily - - - - - - - - - - - - MFS_1,Sugar_tr k59_1757578_1 1121904.ARBP01000024_gene6651 6e-31 125.0 COG1409@1|root,COG4775@1|root,COG1409@2|Bacteria,COG4775@2|Bacteria,4NI9F@976|Bacteroidetes,47TSW@768503|Cytophagia 976|Bacteroidetes M Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes - - - - - - - - - - - - - k59_627732_1 1301098.PKB_5087 1.23e-56 192.0 COG1066@1|root,COG1066@2|Bacteria,1MUJQ@1224|Proteobacteria,1RN2E@1236|Gammaproteobacteria 1236|Gammaproteobacteria O DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function radA GO:0000725,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009314,GO:0009628,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363 - ko:K04485 - - - - ko00000,ko03400 - - - AAA_25,ATPase,ChlI k59_1645015_2 439235.Dalk_0134 1.43e-16 81.6 COG0568@1|root,COG0568@2|Bacteria,1MVWR@1224|Proteobacteria,42NRM@68525|delta/epsilon subdivisions,2WJ0S@28221|Deltaproteobacteria,2MHVP@213118|Desulfobacterales 28221|Deltaproteobacteria K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released rpoH - - ko:K03086,ko:K03089 - - - - ko00000,ko03021 - - - Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4 k59_1475513_1 589865.DaAHT2_1179 2.39e-89 268.0 COG3640@1|root,COG3640@2|Bacteria,1R819@1224|Proteobacteria,42PQR@68525|delta/epsilon subdivisions,2WKE4@28221|Deltaproteobacteria,2MIKC@213118|Desulfobacterales 28221|Deltaproteobacteria D PFAM Cobyrinic acid ac-diamide synthase - - - ko:K07321 - - - - ko00000 - - - CbiA k59_1023831_1 316407.85675915 2.13e-153 440.0 COG0814@1|root,COG0814@2|Bacteria,1QB56@1224|Proteobacteria,1RMJ8@1236|Gammaproteobacteria,3XP6Z@561|Escherichia 1236|Gammaproteobacteria E Involved in the import of threonine and serine into the cell, with the concomitant import of a proton (symport system) tdcC GO:0003333,GO:0003674,GO:0005215,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006855,GO:0006865,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0015075,GO:0015077,GO:0015078,GO:0015171,GO:0015175,GO:0015179,GO:0015194,GO:0015195,GO:0015238,GO:0015291,GO:0015293,GO:0015294,GO:0015295,GO:0015318,GO:0015672,GO:0015711,GO:0015804,GO:0015807,GO:0015825,GO:0015826,GO:0015849,GO:0015893,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0022889,GO:0022890,GO:0031224,GO:0031226,GO:0032329,GO:0034220,GO:0042221,GO:0042493,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0098655,GO:0098656,GO:0098660,GO:0098662,GO:1902475,GO:1902600,GO:1903825,GO:1905039 - ko:K03838 - - - - ko00000,ko02000 2.A.42.2.2 - iAPECO1_1312.APECO1_3308,iE2348C_1286.E2348C_3406,iEC55989_1330.EC55989_3533,iECABU_c1320.ECABU_c35330,iECED1_1282.ECED1_3781,iECIAI1_1343.ECIAI1_3265,iECNA114_1301.ECNA114_4343,iECO103_1326.ECO103_3863,iECO26_1355.ECO26_4221,iECOK1_1307.ECOK1_3543,iECP_1309.ECP_3209,iECSE_1348.ECSE_3400,iECSF_1327.ECSF_2956,iECW_1372.ECW_m3385,iEKO11_1354.EKO11_0601,iLF82_1304.LF82_2232,iNRG857_1313.NRG857_15495,iSBO_1134.SBO_2981,iSbBS512_1146.SbBS512_E3241,iUMN146_1321.UM146_00750,iUTI89_1310.UTI89_C3551,iWFL_1372.ECW_m3385,ic_1306.c3874 Aa_trans,Trp_Tyr_perm k59_458290_1 1123368.AUIS01000003_gene1813 5.02e-121 361.0 COG0189@1|root,COG0189@2|Bacteria,1MX5X@1224|Proteobacteria,1RNXP@1236|Gammaproteobacteria,2NDPB@225057|Acidithiobacillales 225057|Acidithiobacillales HJ RimK-like ATPgrasp N-terminal domain - - - - - - - - - - - - RLAN k59_910274_1 96561.Dole_1103 5.3e-13 69.3 COG0755@1|root,COG0755@2|Bacteria,1RG0A@1224|Proteobacteria,42N37@68525|delta/epsilon subdivisions,2WIKV@28221|Deltaproteobacteria,2MHQ1@213118|Desulfobacterales 28221|Deltaproteobacteria O PFAM Cytochrome C assembly protein - - - - - - - - - - - - Cytochrom_C_asm k59_910274_2 314345.SPV1_11601 1.37e-17 83.6 COG1333@1|root,COG1333@2|Bacteria,1N6XE@1224|Proteobacteria 1224|Proteobacteria O PFAM ResB family protein resB - - ko:K07399 - - - - ko00000 - - - ResB k59_1306032_1 702113.PP1Y_AT11749 5.94e-52 167.0 COG1846@1|root,COG1846@2|Bacteria 2|Bacteria K DNA-binding transcription factor activity - - - ko:K06075 - - - - ko00000,ko03000 - - - MarR,MarR_2 k59_1362275_1 998674.ATTE01000001_gene293 5.67e-90 290.0 COG0749@1|root,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,1RNBG@1236|Gammaproteobacteria,45ZUW@72273|Thiotrichales 72273|Thiotrichales L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity polA - 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1 k59_175807_1 1229909.NSED_03070 3.1e-121 357.0 COG1253@1|root,arCOG00626@2157|Archaea 2157|Archaea S COG1253 Hemolysins and related proteins containing CBS domains cbs9 - - ko:K03699 - - - - ko00000,ko02042 - - - CBS,CorC_HlyC,DUF21 k59_175807_2 1131266.ARWQ01000034_gene706 1.9e-15 83.6 COG3794@1|root,arCOG07813@1|root,arCOG10599@1|root,arCOG02926@2157|Archaea,arCOG07813@2157|Archaea,arCOG10599@2157|Archaea 2157|Archaea C copper ion binding - - 2.4.99.18,3.5.1.56 ko:K03418,ko:K07151 ko00510,ko00513,ko00630,ko01100,ko04141,map00510,map00513,map00630,map01100,map04141 M00072 R02509,R04216,R05976 RC00005,RC00111,RC00482,RC00731 ko00000,ko00001,ko00002,ko01000,ko01003 - GT66 - Laminin_G_3,PKD,Pilin_N,STT3 k59_1700987_2 1120951.AUBG01000003_gene2765 1.71e-22 96.3 COG2207@1|root,COG3063@1|root,COG5616@1|root,COG2207@2|Bacteria,COG3063@2|Bacteria,COG5616@2|Bacteria,4NFW7@976|Bacteroidetes,1HZQR@117743|Flavobacteriia 976|Bacteroidetes K COGs COG5616 integral membrane protein - - - - - - - - - - - - ANAPC3,HTH_18,TPR_2,TPR_8 k59_1023850_1 1120956.JHZK01000021_gene1628 1.49e-10 58.2 COG1380@1|root,COG1380@2|Bacteria,1N753@1224|Proteobacteria,2UFFT@28211|Alphaproteobacteria,1JPI7@119043|Rhodobiaceae 28211|Alphaproteobacteria S LrgA family lrgA - - ko:K06518 - - - - ko00000,ko02000 1.E.14.2 - - LrgA k59_1023850_2 1380394.JADL01000001_gene3047 4.7e-45 150.0 COG1765@1|root,COG1765@2|Bacteria,1R9XU@1224|Proteobacteria,2U6E4@28211|Alphaproteobacteria,2JS0C@204441|Rhodospirillales 204441|Rhodospirillales O OsmC-like protein - - - - - - - - - - - - OsmC k59_1362284_1 754477.Q7C_596 1.32e-113 338.0 COG0014@1|root,COG0014@2|Bacteria,1MUGJ@1224|Proteobacteria,1RMAY@1236|Gammaproteobacteria,45ZMN@72273|Thiotrichales 72273|Thiotrichales E Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate proA - 1.2.1.41 ko:K00147 ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230 M00015 R03313 RC00684 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_345823_1 288000.BBta_6814 6.25e-235 729.0 COG1020@1|root,COG1020@2|Bacteria,1QK4F@1224|Proteobacteria,2TRUN@28211|Alphaproteobacteria,3JQV9@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria Q Phosphopantetheine attachment site - - - - - - - - - - - - AMP-binding,AMP-binding_C,Condensation,PP-binding k59_570986_1 867903.ThesuDRAFT_01424 1.45e-47 166.0 COG1090@1|root,COG1090@2|Bacteria,1TRCE@1239|Firmicutes,24GWH@186801|Clostridia 186801|Clostridia S PFAM NAD dependent epimerase dehydratase family - - - ko:K07071 - - - - ko00000 - - - DUF1731,Epimerase k59_854205_1 1121022.ABENE_21950 1.75e-73 232.0 COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,2TSGZ@28211|Alphaproteobacteria,2KHQT@204458|Caulobacterales 204458|Caulobacterales L PFAM transposase IS116 IS110 IS902 family protein - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_401777_1 316057.RPD_2516 9.75e-83 266.0 COG3119@1|root,COG3119@2|Bacteria,1MUJH@1224|Proteobacteria,2TSB8@28211|Alphaproteobacteria,3JVKE@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria P Sulfatase aslA - 3.1.6.1 ko:K01130,ko:K01138 ko00140,ko00600,map00140,map00600 - R03980,R04856 RC00128,RC00231 ko00000,ko00001,ko01000 - - - Sulfatase,Sulfatase_C k59_8049_1 1313265.JNIE01000007_gene59 3.67e-27 111.0 COG1840@1|root,COG1840@2|Bacteria 2|Bacteria P iron ion homeostasis fbpA GO:0005575,GO:0005623,GO:0042597,GO:0044464 - ko:K02012 ko02010,map02010 M00190 - - ko00000,ko00001,ko00002,ko02000 3.A.1.10 - iJN678.sufA SBP_bac_6,SBP_bac_8 k59_1702264_1 1088721.NSU_3886 2.81e-108 317.0 2D4T1@1|root,32THI@2|Bacteria,1N892@1224|Proteobacteria,2TWF7@28211|Alphaproteobacteria,2KEER@204457|Sphingomonadales 204457|Sphingomonadales S PFAM SapC family protein - - - - - - - - - - - - SapC k59_742244_1 504832.OCAR_6057 1.57e-19 96.7 COG4597@1|root,COG4597@2|Bacteria,1MV0S@1224|Proteobacteria,2TR7G@28211|Alphaproteobacteria,3JV9Y@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria E amino acid ABC transporter MA20_30065 - - ko:K09970 ko02010,map02010 M00232 - - ko00000,ko00001,ko00002,ko02000 3.A.1.3.18,3.A.1.3.7,3.A.1.3.8 - - BPD_transp_1 k59_1646373_1 1229909.NSED_08330 2.35e-160 453.0 COG0714@1|root,arCOG00441@2157|Archaea,41SDZ@651137|Thaumarchaeota 651137|Thaumarchaeota S ATPase family associated with various cellular activities (AAA) - - - ko:K04748 - - R00294 RC02794 ko00000 3.D.4.10 - - AAA_5 k59_1702268_1 710686.Mycsm_02005 1.16e-24 103.0 COG2124@1|root,COG2124@2|Bacteria,2GJ8V@201174|Actinobacteria,2369W@1762|Mycobacteriaceae 201174|Actinobacteria Q cytochrome p450 cyp128 GO:0003674,GO:0003824,GO:0006629,GO:0008150,GO:0008152,GO:0008202,GO:0016125,GO:0016491,GO:0040007,GO:0044238,GO:0055114,GO:0071704,GO:1901360,GO:1901615 - ko:K21199 - - - - ko00000,ko00199 - - - p450 k59_1533234_1 1122134.KB893651_gene2042 7.82e-112 347.0 COG2609@1|root,COG2609@2|Bacteria,1MV21@1224|Proteobacteria,1RN6K@1236|Gammaproteobacteria,1XHJR@135619|Oceanospirillales 135619|Oceanospirillales C Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) aceE - 1.2.4.1 ko:K00163 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200 M00307 R00014,R00209,R01699,R03270 RC00004,RC00027,RC00627,RC02742,RC02744,RC02882 br01601,ko00000,ko00001,ko00002,ko01000 - - - Transketolase_N k59_233488_1 1279017.AQYJ01000029_gene3313 1.05e-54 189.0 COG0511@1|root,COG5016@1|root,COG0511@2|Bacteria,COG5016@2|Bacteria,1QTTG@1224|Proteobacteria,1RNG6@1236|Gammaproteobacteria,4659U@72275|Alteromonadaceae 1236|Gammaproteobacteria CI COG5016 Pyruvate oxaloacetate carboxyltransferase oadA - 4.1.1.3 ko:K01571 ko00620,ko01100,map00620,map01100 - R00217 RC00040 ko00000,ko00001,ko01000,ko02000 3.B.1.1.1 - - Biotin_lipoyl,HMGL-like,PYC_OADA k59_177057_1 1220535.IMCC14465_05990 7.59e-49 170.0 COG1459@1|root,COG1459@2|Bacteria,1MV4U@1224|Proteobacteria,2TV76@28211|Alphaproteobacteria,4BQK9@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria NU Type II secretion system (T2SS), protein F gspF - - ko:K02455,ko:K02653 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02035,ko02044 3.A.15,3.A.15.2 - - T2SSF k59_1476929_1 1031711.RSPO_c02035 1.74e-111 330.0 COG0463@1|root,COG0463@2|Bacteria,1MWE5@1224|Proteobacteria,2VJ5G@28216|Betaproteobacteria,1KIEQ@119060|Burkholderiaceae 28216|Betaproteobacteria M Glycosyl transferase family 2 arnC - 2.4.2.53 ko:K10012 ko00520,ko01503,map00520,map01503 M00721,M00761 R07661 RC00005,RC02954 ko00000,ko00001,ko00002,ko01000,ko01005,ko02000 4.D.2.1.8 GT2 - Glycos_transf_2 k59_629023_3 744980.TRICHSKD4_0922 1.25e-30 111.0 COG1403@1|root,COG1403@2|Bacteria,1NACN@1224|Proteobacteria,2UI6R@28211|Alphaproteobacteria 28211|Alphaproteobacteria L HNH nucleases - - - - - - - - - - - - HNH k59_1194111_1 1397528.Q671_09350 2.96e-32 125.0 COG1354@1|root,COG1354@2|Bacteria,1MVCN@1224|Proteobacteria,1RNBB@1236|Gammaproteobacteria,1XHG7@135619|Oceanospirillales 135619|Oceanospirillales D Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves scpA - - ko:K05896 - - - - ko00000,ko03036 - - - SMC_ScpA k59_459647_1 483219.LILAB_36350 6.23e-67 237.0 COG4796@1|root,COG4796@2|Bacteria,1QTT6@1224|Proteobacteria,42MKN@68525|delta/epsilon subdivisions,2WJV6@28221|Deltaproteobacteria,2YTV4@29|Myxococcales 28221|Deltaproteobacteria U type IV pilus secretin PilQ pilQ - - ko:K02666 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - AMIN,STN,Secretin,Secretin_N k59_799288_1 1096930.L284_04300 2.75e-138 398.0 COG0463@1|root,COG0463@2|Bacteria,1MWE5@1224|Proteobacteria,2TRRT@28211|Alphaproteobacteria,2K3MJ@204457|Sphingomonadales 204457|Sphingomonadales M Glycosyltransferase like family 2 - - - ko:K20534 - - - - ko00000,ko01000,ko01005,ko02000 4.D.2.1.9 GT2 - Glycos_transf_2 k59_1081060_1 1165096.ARWF01000001_gene2254 2.92e-51 184.0 COG0658@1|root,COG2333@1|root,COG0658@2|Bacteria,COG2333@2|Bacteria,1MUKF@1224|Proteobacteria,2VHKP@28216|Betaproteobacteria,2KMAI@206350|Nitrosomonadales 206350|Nitrosomonadales S DNA internalization-related competence protein ComEC Rec2 - - - ko:K02238 - M00429 - - ko00000,ko00002,ko02044 3.A.11.1,3.A.11.2 - - Competence,DUF4131,Lactamase_B k59_799294_1 1120966.AUBU01000008_gene2453 3.58e-13 73.9 COG0760@1|root,COG0760@2|Bacteria,4NGIR@976|Bacteroidetes,47K78@768503|Cytophagia 976|Bacteroidetes O peptidyl-prolyl isomerase - - 5.2.1.8 ko:K03771 - - - - ko00000,ko01000,ko03110 - - - Rotamase,Rotamase_2,Rotamase_3 k59_629034_1 1134474.O59_002614 2.51e-123 363.0 COG1312@1|root,COG1312@2|Bacteria,1MWYD@1224|Proteobacteria,1RR0Q@1236|Gammaproteobacteria,1FGM6@10|Cellvibrio 1236|Gammaproteobacteria G D-mannonate dehydratase (UxuA) uxuA - 4.2.1.8 ko:K01686 ko00040,ko01100,map00040,map01100 M00061 R05606 RC00543 ko00000,ko00001,ko00002,ko01000 - - - UxuA k59_1702278_1 1088721.NSU_4025 1.9e-87 274.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,2TQQE@28211|Alphaproteobacteria,2K2U5@204457|Sphingomonadales 204457|Sphingomonadales NT chemotaxis protein - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - MCPsignal k59_855556_1 1288826.MSNKSG1_04501 7.85e-83 265.0 COG0556@1|root,COG0556@2|Bacteria,1MUFK@1224|Proteobacteria,1RN6Z@1236|Gammaproteobacteria,4645B@72275|Alteromonadaceae 1236|Gammaproteobacteria L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage uvrB GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009314,GO:0009380,GO:0009628,GO:0032991,GO:0042802,GO:0044424,GO:0044464,GO:0050896,GO:1902494,GO:1905347,GO:1905348,GO:1990391 - ko:K03702 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - Helicase_C,ResIII,UVR,UvrB k59_64886_1 743718.Isova_0153 4.95e-113 338.0 COG4222@1|root,COG4222@2|Bacteria,2GJN8@201174|Actinobacteria,4F3JV@85017|Promicromonosporaceae 201174|Actinobacteria S Endonuclease/Exonuclease/phosphatase family - - - - - - - - - - - - Exo_endo_phos k59_515683_1 1123518.ARWI01000001_gene2123 6.22e-20 88.2 COG0352@1|root,COG0494@1|root,COG0352@2|Bacteria,COG0494@2|Bacteria,1RCZM@1224|Proteobacteria,1RS3S@1236|Gammaproteobacteria,460MT@72273|Thiotrichales 72273|Thiotrichales L Belongs to the Nudix hydrolase family - - 3.6.1.55 ko:K03574 - - - - ko00000,ko01000,ko03400 - - - NUDIX,NUDIX_4,TMP-TENI k59_799303_1 1122137.AQXF01000006_gene873 1.28e-48 161.0 COG2761@1|root,COG2761@2|Bacteria,1NXUB@1224|Proteobacteria,2TRJ6@28211|Alphaproteobacteria 28211|Alphaproteobacteria Q dithiol-disulfide isomerase involved in polyketide biosynthesis dsb - - - - - - - - - - - DSBA k59_911813_1 1265313.HRUBRA_00460 1.04e-10 62.0 COG1520@1|root,COG1520@2|Bacteria,1MXIJ@1224|Proteobacteria,1RN4V@1236|Gammaproteobacteria,1J5PH@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane bamB GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0008104,GO:0008150,GO:0008152,GO:0009279,GO:0009987,GO:0016020,GO:0016043,GO:0016491,GO:0019867,GO:0022607,GO:0030312,GO:0030313,GO:0031224,GO:0031230,GO:0031241,GO:0031246,GO:0031975,GO:0032991,GO:0033036,GO:0034613,GO:0042802,GO:0043163,GO:0043165,GO:0044085,GO:0044091,GO:0044425,GO:0044462,GO:0044464,GO:0045184,GO:0045229,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0055114,GO:0061024,GO:0070727,GO:0071709,GO:0071840,GO:0071944,GO:0072657,GO:0090150,GO:0098552,GO:0098796,GO:1990063 - ko:K17713 - - - - ko00000,ko02000 1.B.33.1 - - PQQ_2,PQQ_3 k59_911813_2 1117647.M5M_04675 9.92e-37 135.0 COG1160@1|root,COG1160@2|Bacteria,1MU9S@1224|Proteobacteria,1RMSF@1236|Gammaproteobacteria,1J4NG@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S GTPase that plays an essential role in the late steps of ribosome biogenesis der GO:0000027,GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005515,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006996,GO:0008150,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0022607,GO:0022613,GO:0022618,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0032794,GO:0034622,GO:0035639,GO:0036094,GO:0042254,GO:0042255,GO:0042273,GO:0043021,GO:0043022,GO:0043023,GO:0043167,GO:0043168,GO:0043933,GO:0044085,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:0097159,GO:0097216,GO:0097367,GO:1901265,GO:1901363 - ko:K03977 - - - - ko00000,ko03009 - - - KH_dom-like,MMR_HSR1 k59_799309_1 1415778.JQMM01000001_gene464 2.1e-134 392.0 COG0499@1|root,COG0499@2|Bacteria,1MUQ2@1224|Proteobacteria,1RMW8@1236|Gammaproteobacteria,1J4SA@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine ahcY GO:0000096,GO:0003674,GO:0003824,GO:0004013,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006534,GO:0006555,GO:0006575,GO:0006725,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009066,GO:0009069,GO:0009116,GO:0009119,GO:0009987,GO:0016787,GO:0016801,GO:0016802,GO:0017144,GO:0019752,GO:0033353,GO:0034641,GO:0042278,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046128,GO:0046439,GO:0046483,GO:0046498,GO:0046500,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564,GO:1901605,GO:1901657 3.3.1.1 ko:K01251 ko00270,ko01100,map00270,map01100 M00035 R00192,R04936 RC00056,RC00069,RC01161,RC01243 ko00000,ko00001,ko00002,ko01000,ko01009,ko04147 - - iYL1228.KPN_02462 AdoHcyase,AdoHcyase_NAD k59_1589233_2 1121870.AUAA01000055_gene1173 2.76e-09 60.1 arCOG10603@1|root,32SV6@2|Bacteria,4NFE9@976|Bacteroidetes,1I3WY@117743|Flavobacteriia,3HIFF@358033|Chryseobacterium 976|Bacteroidetes - - - - - - - - - - - - - - - k59_515686_1 247490.KSU1_A0079 2.85e-09 55.8 2DCC8@1|root,2ZDND@2|Bacteria 2|Bacteria S Hydrogenase/urease nickel incorporation, metallochaperone, hypA - - - - - - - - - - - - HypA k59_515686_2 1173027.Mic7113_3072 5.35e-53 192.0 COG0068@1|root,COG0068@2|Bacteria,1G063@1117|Cyanobacteria,1H71F@1150|Oscillatoriales 1117|Cyanobacteria O Belongs to the carbamoyltransferase HypF family hypF - - ko:K04656 - - - - ko00000 - - - Acylphosphatase,Sua5_yciO_yrdC,zf-HYPF k59_64894_1 706587.Desti_3123 5.16e-34 127.0 COG2805@1|root,COG2805@2|Bacteria,1MU3J@1224|Proteobacteria,42M7F@68525|delta/epsilon subdivisions,2WIMF@28221|Deltaproteobacteria 28221|Deltaproteobacteria NU twitching motility protein pilT-4 - - ko:K02669 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE k59_64894_2 398767.Glov_1655 1.98e-10 62.4 COG1459@1|root,COG1459@2|Bacteria,1MV4U@1224|Proteobacteria,42NES@68525|delta/epsilon subdivisions,2WJ0V@28221|Deltaproteobacteria 28221|Deltaproteobacteria NU Type II secretion system pilC - - ko:K02653 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSF k59_347238_1 90813.JQMT01000001_gene659 2.5e-16 75.5 COG1905@1|root,COG1905@2|Bacteria,1MWS2@1224|Proteobacteria,1RN4C@1236|Gammaproteobacteria,460R3@72273|Thiotrichales 72273|Thiotrichales C NADH dehydrogenase nuoE - 1.6.5.3 ko:K00334 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - 2Fe-2S_thioredx k59_347238_2 671143.DAMO_2696 2.75e-155 452.0 COG1894@1|root,COG1894@2|Bacteria,2NNM1@2323|unclassified Bacteria 2|Bacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain nuoF - 1.6.5.3 ko:K00335 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_51K,NADH_4Fe-4S,SLBB k59_1533280_2 215803.DB30_6769 1.4e-114 359.0 COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,42M4I@68525|delta/epsilon subdivisions,2WJHM@28221|Deltaproteobacteria,2YUJ6@29|Myxococcales 28221|Deltaproteobacteria L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate uvrA - - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - ABC_tran k59_1194142_1 493475.GARC_5231 1.74e-25 102.0 COG0583@1|root,COG0583@2|Bacteria,1MZTA@1224|Proteobacteria,1RN7R@1236|Gammaproteobacteria,466EN@72275|Alteromonadaceae 1236|Gammaproteobacteria K Transcriptional regulator yhaJ GO:0001130,GO:0001216,GO:0003674,GO:0003700,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031334,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043254,GO:0044087,GO:0044089,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0045893,GO:0045935,GO:0046483,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051128,GO:0051130,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901576,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2000142,GO:2000144,GO:2001141 - - - - - - - - - - HTH_1,LysR_substrate k59_1194142_2 270374.MELB17_15601 5.82e-66 204.0 COG2259@1|root,COG2259@2|Bacteria,1RDYW@1224|Proteobacteria,1S3RT@1236|Gammaproteobacteria,466SA@72275|Alteromonadaceae 1236|Gammaproteobacteria S DoxX - - - ko:K15977 - - - - ko00000 - - - DoxX k59_799317_1 309801.trd_A0852 1.37e-08 55.1 COG0717@1|root,COG0717@2|Bacteria,2GBA2@200795|Chloroflexi,27Y8U@189775|Thermomicrobia 189775|Thermomicrobia F dUTPase - - 3.5.4.13 ko:K01494 ko00240,ko01100,map00240,map01100 M00053 R00568,R02325 RC00074 ko00000,ko00001,ko00002,ko01000 - - - dUTPase k59_799317_2 994479.GL877879_gene4909 6.17e-38 141.0 COG0584@1|root,COG0584@2|Bacteria,2GJ5W@201174|Actinobacteria,4DZWJ@85010|Pseudonocardiales 201174|Actinobacteria C glycerophosphoryl diester phosphodiesterase glpQ2 - 3.1.4.46 ko:K01126 ko00564,map00564 - R01030,R01470 RC00017,RC00425 ko00000,ko00001,ko01000 - - - GDPD k59_121112_1 1219045.BV98_002116 4.12e-119 350.0 COG0789@1|root,COG1192@1|root,COG0789@2|Bacteria,COG1192@2|Bacteria,1MVJU@1224|Proteobacteria,2TRYQ@28211|Alphaproteobacteria,2K10I@204457|Sphingomonadales 204457|Sphingomonadales D Chromosome partitioning - - - ko:K03496 - - - - ko00000,ko03036,ko04812 - - - AAA_31 k59_233517_1 1205753.A989_04678 8.19e-55 188.0 COG3202@1|root,COG3202@2|Bacteria,1MVP5@1224|Proteobacteria,1RNY6@1236|Gammaproteobacteria,1X4WT@135614|Xanthomonadales 135614|Xanthomonadales C Major Facilitator Superfamily - - - ko:K03301 - - - - ko00000 2.A.12 - - MFS_1 k59_629047_2 981384.AEYW01000013_gene538 1.54e-45 164.0 COG2114@1|root,COG2114@2|Bacteria,1NC69@1224|Proteobacteria,2VFPU@28211|Alphaproteobacteria 1224|Proteobacteria T SnoaL-like domain - - - - - - - - - - - - Guanylate_cyc,SnoaL_3 k59_629047_3 33876.JNXY01000021_gene4797 3.86e-11 64.7 COG1846@1|root,COG1846@2|Bacteria,2IQU8@201174|Actinobacteria,4DJDM@85008|Micromonosporales 201174|Actinobacteria K helix_turn_helix multiple antibiotic resistance protein - - - - - - - - - - - - MarR,MarR_2 k59_911829_1 523791.Kkor_1338 3.49e-85 261.0 COG2896@1|root,COG2896@2|Bacteria,1MW3W@1224|Proteobacteria,1RR68@1236|Gammaproteobacteria,1XHTC@135619|Oceanospirillales 135619|Oceanospirillales H Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate moaA - 4.1.99.22 ko:K03639 ko00790,ko01100,ko04122,map00790,map01100,map04122 - R09394 RC03420 ko00000,ko00001,ko01000 - - - Fer4_12,Mob_synth_C,Radical_SAM k59_1025400_1 640081.Dsui_3030 8.08e-129 385.0 COG1894@1|root,COG1905@1|root,COG1894@2|Bacteria,COG1905@2|Bacteria,1MV8F@1224|Proteobacteria,2VHW2@28216|Betaproteobacteria,2KUYG@206389|Rhodocyclales 206389|Rhodocyclales C Respiratory-chain NADH dehydrogenase hoxF - 1.12.1.2 ko:K18005 - - - - ko00000,ko01000 - - - 2Fe-2S_thioredx,Complex1_51K,NADH_4Fe-4S,SLBB k59_8138_1 1121022.ABENE_20725 2.74e-37 147.0 COG1413@1|root,COG1413@2|Bacteria,1R4FD@1224|Proteobacteria 1224|Proteobacteria C Domain of unknown function (DUF4132) - - - - - - - - - - - - DUF4132,HEAT_2 k59_1533313_1 1122137.AQXF01000006_gene728 3.14e-90 277.0 COG4664@1|root,COG4664@2|Bacteria,1R4MZ@1224|Proteobacteria,2TQNR@28211|Alphaproteobacteria 28211|Alphaproteobacteria Q TRAP-type mannitol chloroaromatic compound transport system large permease component - - - - - - - - - - - - DctM k59_347259_1 1122137.AQXF01000001_gene2923 3.32e-129 371.0 COG4181@1|root,COG4181@2|Bacteria,1MXG9@1224|Proteobacteria,2TS0J@28211|Alphaproteobacteria 28211|Alphaproteobacteria Q ABC-type transport system involved in lysophospholipase L1 biosynthesis ATPase component ybbA GO:0000166,GO:0003674,GO:0005488,GO:0005524,GO:0008144,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_347259_2 1121028.ARQE01000001_gene3469 3.13e-06 49.7 COG2755@1|root,COG2755@2|Bacteria,1RCXZ@1224|Proteobacteria,2U74E@28211|Alphaproteobacteria,2PJQW@255475|Aurantimonadaceae 28211|Alphaproteobacteria E GDSL-like Lipase/Acylhydrolase tesA - 3.1.1.5 ko:K10804 ko01040,map01040 - - - ko00000,ko00001,ko01000,ko01004 - - - Lipase_GDSL_2 k59_515718_1 1123269.NX02_11300 1.82e-19 86.3 COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2TQR1@28211|Alphaproteobacteria,2JZVD@204457|Sphingomonadales 204457|Sphingomonadales C belongs to the aldehyde dehydrogenase family - - - ko:K00138 ko00010,ko00620,ko01100,ko01110,ko01120,map00010,map00620,map01100,map01110,map01120 - R00711 RC00047 ko00000,ko00001,ko01000 - - - Aldedh k59_515718_2 316055.RPE_4493 5.66e-16 74.3 COG3224@1|root,COG3224@2|Bacteria,1N2DP@1224|Proteobacteria,2UBSR@28211|Alphaproteobacteria,3JZK5@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S EthD domain - - - - - - - - - - - - EthD k59_515718_3 702113.PP1Y_AT5681 9.61e-31 110.0 COG3564@1|root,COG3564@2|Bacteria,1RGYH@1224|Proteobacteria,2U9NU@28211|Alphaproteobacteria,2K4ER@204457|Sphingomonadales 204457|Sphingomonadales S Protein of unknown function (DUF779) - - - ko:K09959 - - - - ko00000 - - - DUF779 k59_1316988_1 1288494.EBAPG3_21520 2.44e-129 389.0 COG1009@1|root,COG1009@2|Bacteria,1MW2M@1224|Proteobacteria,2VJ2J@28216|Betaproteobacteria,371N6@32003|Nitrosomonadales 28216|Betaproteobacteria C chain 5 L nuoL - 1.6.5.3 ko:K00341 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Proton_antipo_C,Proton_antipo_M,Proton_antipo_N k59_74607_1 1318628.MARLIPOL_05145 2.21e-60 199.0 COG0644@1|root,COG0644@2|Bacteria,1MXQY@1224|Proteobacteria,1SEJ8@1236|Gammaproteobacteria 1236|Gammaproteobacteria C geranylgeranyl reductase - - - - - - - - - - - - FAD_binding_3 k59_1598977_1 330214.NIDE0360 2.86e-57 195.0 COG0706@1|root,COG0706@2|Bacteria,3J0GD@40117|Nitrospirae 40117|Nitrospirae U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins yidC - - ko:K03217 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044,ko03029 2.A.9 - - 60KD_IMP,YidC_periplas k59_130408_1 1123401.JHYQ01000009_gene2282 4.37e-33 124.0 COG0189@1|root,COG0189@2|Bacteria,1MV29@1224|Proteobacteria,1SB70@1236|Gammaproteobacteria 1236|Gammaproteobacteria HJ COG0189 Glutathione synthase Ribosomal protein S6 modification enzyme (glutaminyl transferase) dcsG - - - - - - - - - - - GSH-S_ATP,RimK k59_1259830_1 1056816.JAFQ01000004_gene1231 2.54e-34 134.0 COG0204@1|root,COG0560@1|root,COG0204@2|Bacteria,COG0560@2|Bacteria,2GJVX@201174|Actinobacteria,4FUIH@85025|Nocardiaceae 201174|Actinobacteria EI Phosphate acyltransferases plsC - 2.3.1.51,3.1.3.3 ko:K00655,ko:K15781 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R02241,R09381 RC00004,RC00037,RC00039 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Acyltransferase,HAD k59_1259832_1 1197477.IA57_08190 1.85e-135 395.0 COG0726@1|root,COG0726@2|Bacteria,4NF79@976|Bacteroidetes,1HWXT@117743|Flavobacteriia 976|Bacteroidetes G polysaccharide deacetylase - - - - - - - - - - - - - k59_1146957_1 1229909.NSED_09740 1.14e-134 387.0 COG1405@1|root,arCOG01981@2157|Archaea,41SXZ@651137|Thaumarchaeota 651137|Thaumarchaeota K Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB) - - - ko:K03124 ko03022,ko05169,ko05203,map03022,map05169,map05203 - - - ko00000,ko00001,ko03021 - - - TFIIB,TF_Zn_Ribbon k59_525015_1 522306.CAP2UW1_1374 2.2e-109 323.0 COG1235@1|root,COG1235@2|Bacteria,1R5N4@1224|Proteobacteria,2VKSE@28216|Betaproteobacteria,1KQW1@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria S Beta-lactamase superfamily domain - - - - - - - - - - - - Lactamase_B_2 k59_751522_1 1282361.ABAC402_13670 1.37e-13 73.9 COG0612@1|root,COG0612@2|Bacteria,1NAH6@1224|Proteobacteria,2U0S5@28211|Alphaproteobacteria,2KFX1@204458|Caulobacterales 204458|Caulobacterales S Belongs to the peptidase M16 family - - - ko:K07263 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M16,Peptidase_M16_C k59_751522_2 794903.OPIT5_28945 1.56e-14 72.4 COG0235@1|root,COG0235@2|Bacteria,46ZM6@74201|Verrucomicrobia,3K73A@414999|Opitutae 414999|Opitutae G Class II Aldolase and Adducin N-terminal domain - - 4.1.2.17 ko:K01628 ko00051,ko01120,map00051,map01120 - R02262 RC00603,RC00604 ko00000,ko00001,ko01000 - - - Aldolase_II k59_583067_1 1027273.GZ77_22515 3.06e-161 494.0 COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,1RNBG@1236|Gammaproteobacteria,1XI69@135619|Oceanospirillales 135619|Oceanospirillales L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity polA - 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1 k59_470228_1 1121921.KB898707_gene1168 3.16e-107 325.0 COG0442@1|root,COG0442@2|Bacteria,1MU7E@1224|Proteobacteria,1RN5R@1236|Gammaproteobacteria,2PMXW@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria J Aminoacyl-tRNA editing domain proS GO:0002161,GO:0003674,GO:0003824,GO:0004812,GO:0004827,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006433,GO:0006450,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0043906,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.15 ko:K01881 ko00970,map00970 M00359,M00360 R03661 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iUTI89_1310.UTI89_C0210 HGTP_anticodon,tRNA-synt_2b,tRNA_edit k59_977864_1 754477.Q7C_1194 7.24e-51 171.0 COG0564@1|root,COG0564@2|Bacteria,1MUBN@1224|Proteobacteria,1RN7F@1236|Gammaproteobacteria,45ZTJ@72273|Thiotrichales 72273|Thiotrichales J Responsible for synthesis of pseudouridine from uracil rluD - 5.4.99.23 ko:K06180 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2,S4 k59_977864_2 686340.Metal_3259 4.74e-45 155.0 COG1496@1|root,COG1496@2|Bacteria,1MW2H@1224|Proteobacteria,1RNV4@1236|Gammaproteobacteria,1XEWQ@135618|Methylococcales 135618|Methylococcales S Belongs to the multicopper oxidase YfiH RL5 family - - - ko:K05810 - - - - ko00000,ko01000 - - - Cu-oxidase_4 k59_75807_1 754477.Q7C_2661 3.78e-105 311.0 COG0078@1|root,COG0078@2|Bacteria,1MUFM@1224|Proteobacteria,1RQ59@1236|Gammaproteobacteria,460CS@72273|Thiotrichales 72273|Thiotrichales E Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline argF - 2.1.3.3 ko:K00611 ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230 M00029,M00844 R01398 RC00096 ko00000,ko00001,ko00002,ko01000 - - - OTCace,OTCace_N k59_526140_1 1121935.AQXX01000139_gene3042 3.97e-128 385.0 COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,1RR14@1236|Gammaproteobacteria,1XIX7@135619|Oceanospirillales 135619|Oceanospirillales I COG0365 Acyl-coenzyme A synthetases AMP-(fatty) acid ligases prpE - 6.2.1.17 ko:K01908 ko00640,ko01100,map00640,map01100 - R00926,R01354 RC00004,RC00043,RC00070,RC02816 ko00000,ko00001,ko01000,ko01004 - - - ACAS_N,AMP-binding,AMP-binding_C k59_977887_1 1122137.AQXF01000002_gene333 8.4e-29 105.0 COG0633@1|root,COG0633@2|Bacteria,1RHDC@1224|Proteobacteria,2U97J@28211|Alphaproteobacteria 28211|Alphaproteobacteria C ferredoxin fdx - - ko:K04755 - - - - ko00000 - - - Fer2 k59_977887_2 1316936.K678_08314 3.97e-66 218.0 COG1104@1|root,COG1104@2|Bacteria,1MU1C@1224|Proteobacteria,2TSQE@28211|Alphaproteobacteria,2JPHR@204441|Rhodospirillales 204441|Rhodospirillales E Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins iscS - 2.8.1.7 ko:K04487 ko00730,ko01100,ko04122,map00730,map01100,map04122 - R07460,R11528,R11529 RC01789,RC02313 ko00000,ko00001,ko01000,ko02048,ko03016,ko03029 - - - Aminotran_5 k59_1769659_1 1027273.GZ77_07930 4.62e-56 185.0 COG0297@1|root,COG0297@2|Bacteria,1R028@1224|Proteobacteria,1T4E9@1236|Gammaproteobacteria,1XRY8@135619|Oceanospirillales 135619|Oceanospirillales G Glycosyl transferase - - - - - - - - - - - - DUF3524,Glycos_transf_1 k59_1769659_2 1382306.JNIM01000001_gene3600 4.27e-06 49.3 COG0607@1|root,COG0607@2|Bacteria,2G71Z@200795|Chloroflexi 200795|Chloroflexi P PFAM Rhodanese domain protein - - - - - - - - - - - - Rhodanese k59_357990_1 926562.Oweho_1948 5.96e-38 135.0 COG2928@1|root,COG2928@2|Bacteria,4NR4F@976|Bacteroidetes,1I06H@117743|Flavobacteriia 976|Bacteroidetes S Protein of unknown function (DUF502) - - - - - - - - - - - - DUF502 k59_131527_1 518766.Rmar_2140 1.16e-83 259.0 COG3676@1|root,COG3677@1|root,COG3676@2|Bacteria,COG3677@2|Bacteria,4NS7V@976|Bacteroidetes 976|Bacteroidetes L ISXO2-like transposase domain - - - - - - - - - - - - DDE_Tnp_IS1595,Zn_Tnp_IS1595 k59_1713057_1 404589.Anae109_1393 6.13e-26 114.0 COG0312@1|root,COG0312@2|Bacteria,1Q3C0@1224|Proteobacteria,4393A@68525|delta/epsilon subdivisions,2X495@28221|Deltaproteobacteria,2YYIX@29|Myxococcales 28221|Deltaproteobacteria S peptidase U62 modulator of DNA gyrase - - - - - - - - - - - - PmbA_TldD k59_1713057_2 1408254.T458_04045 4.83e-19 97.4 COG0553@1|root,COG0553@2|Bacteria,1TQ5E@1239|Firmicutes,4H9WB@91061|Bacilli,27241@186822|Paenibacillaceae 91061|Bacilli KL SNF2 family N-terminal domain - - - - - - - - - - - - Helicase_C,SNF2_N k59_1318276_1 702113.PP1Y_AT5642 4.51e-27 108.0 COG0156@1|root,COG0156@2|Bacteria,1MVVH@1224|Proteobacteria,2TTAK@28211|Alphaproteobacteria,2JZVV@204457|Sphingomonadales 204457|Sphingomonadales E 8-amino-7-oxononanoate synthase bioF - 2.3.1.47 ko:K00652 ko00780,ko01100,map00780,map01100 M00123,M00573,M00577 R03210,R10124 RC00004,RC00039,RC02725 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 k59_244148_1 876044.IMCC3088_709 1.88e-72 234.0 COG1012@1|root,COG1012@2|Bacteria,1MVGW@1224|Proteobacteria,1RN53@1236|Gammaproteobacteria,1J4US@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Belongs to the aldehyde dehydrogenase family calB - 1.2.1.68 ko:K00154 - - - - ko00000,ko01000 - - - Aldedh k59_1261013_1 1182590.BN5_01247 6.55e-62 214.0 COG0587@1|root,COG0587@2|Bacteria,1MUIF@1224|Proteobacteria,1RP0K@1236|Gammaproteobacteria,1YD2I@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria L DNA polymerase dnaE GO:0003674,GO:0003824,GO:0003887,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032991,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0042575,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044776,GO:0046483,GO:0061695,GO:0071704,GO:0071897,GO:0090304,GO:0140097,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234 2.7.7.7 ko:K02337 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon k59_1318306_1 1122137.AQXF01000004_gene1449 1.96e-95 287.0 COG1281@1|root,COG1281@2|Bacteria,1MUMU@1224|Proteobacteria,2TTUR@28211|Alphaproteobacteria 28211|Alphaproteobacteria O Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress hslO - - ko:K04083 - - - - ko00000,ko03110 - - - HSP33 k59_1091714_1 59374.Fisuc_1862 1.76e-35 125.0 COG0662@1|root,COG0662@2|Bacteria 2|Bacteria G Cupin 2, conserved barrel domain protein - - - ko:K09705 - - - - ko00000 - - - Cupin_2,Cupin_5 k59_1657440_1 388051.AUFE01000005_gene1140 1.21e-58 195.0 COG0501@1|root,COG0501@2|Bacteria,1MUXT@1224|Proteobacteria,2VI1Y@28216|Betaproteobacteria,1K0JS@119060|Burkholderiaceae 28216|Betaproteobacteria O Peptidase M48 htpX_2 - 3.4.24.84 ko:K06013 ko00900,ko01130,map00900,map01130 - R09845 RC00141 ko00000,ko00001,ko01000,ko01002,ko04147 - - - Peptidase_M48,Peptidase_M48_N k59_583141_1 234826.AM584 2.91e-06 49.3 COG1028@1|root,COG1028@2|Bacteria,1MU6X@1224|Proteobacteria,2TQZG@28211|Alphaproteobacteria,47EY4@766|Rickettsiales 766|Rickettsiales IQ dehydrogenases with different specificities (related to short-chain alcohol) fabG GO:0000166,GO:0003674,GO:0003824,GO:0004312,GO:0004316,GO:0005488,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0030497,GO:0032787,GO:0036094,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0072330,GO:0097159,GO:1901265,GO:1901363,GO:1901576 1.1.1.100 ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 k59_583141_2 1040986.ATYO01000030_gene3481 7.78e-57 192.0 COG3618@1|root,COG3618@2|Bacteria,1MVG0@1224|Proteobacteria,2TRQX@28211|Alphaproteobacteria 1224|Proteobacteria S metal-dependent hydrolase of the TIM-barrel fold - - - - - - - - - - - - Amidohydro_2 k59_583141_3 1282362.AEAC466_07425 2.42e-25 101.0 COG4975@1|root,COG4975@2|Bacteria 2|Bacteria G carbohydrate transmembrane transporter activity glcU GO:0003674,GO:0005215,GO:0005355,GO:0006810,GO:0008150,GO:0008643,GO:0008645,GO:0015144,GO:0015145,GO:0015149,GO:0015749,GO:0022857,GO:0034219,GO:0051119,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:1904659 - ko:K05340,ko:K06216 - - - - ko00000,ko02000 2.A.7.5 - - Sugar_transport k59_413734_1 679197.HMPREF9336_00431 2.52e-12 74.3 COG3378@1|root,COG3378@2|Bacteria,2GQQM@201174|Actinobacteria 201174|Actinobacteria S Phage plasmid primase P4 family - - - - - - - - - - - - D5_N k59_131563_2 436308.Nmar_1338 3.05e-29 114.0 COG4742@1|root,arCOG04362@2157|Archaea,41SGE@651137|Thaumarchaeota 651137|Thaumarchaeota K Transcriptional regulator - - - - - - - - - - - - HTH_20,HTH_5 k59_18687_1 316407.85675243 1.78e-97 290.0 COG1125@1|root,COG1125@2|Bacteria,1QTUC@1224|Proteobacteria,1RQWQ@1236|Gammaproteobacteria,3XNHI@561|Escherichia 1236|Gammaproteobacteria P ATP-binding protein yehX GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0015695,GO:0015696,GO:0015697,GO:0015838,GO:0031460,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0072337 - ko:K05847 ko02010,map02010 M00209 - - ko00000,ko00001,ko00002,ko02000 3.A.1.12 - iECED1_1282.ECED1_2573,iEcE24377_1341.EcE24377A_2418,iPC815.YPO1198 ABC_tran,CBS k59_18687_2 316407.85675244 2.27e-47 162.0 COG1174@1|root,COG1174@2|Bacteria,1MXA1@1224|Proteobacteria,1RQDV@1236|Gammaproteobacteria,3XN5U@561|Escherichia 1236|Gammaproteobacteria P Permease protein yehY GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0015695,GO:0015696,GO:0015697,GO:0015838,GO:0016020,GO:0031460,GO:0044464,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944,GO:0072337 - ko:K05846 ko02010,map02010 M00209 - - ko00000,ko00001,ko00002,ko02000 3.A.1.12 - iECNA114_1301.ECNA114_2219,iECSF_1327.ECSF_2012,iETEC_1333.ETEC_2266 BPD_transp_1 k59_583151_1 436308.Nmar_0599 2.05e-80 249.0 COG4046@1|root,arCOG04181@2157|Archaea,41S8T@651137|Thaumarchaeota 651137|Thaumarchaeota S Protein of unknown function (DUF1512) - - - - - - - - - - - - DUF1512 k59_583153_1 436308.Nmar_1591 2.04e-34 132.0 arCOG07442@1|root,arCOG07442@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_977939_1 1122137.AQXF01000001_gene2986 1.68e-38 139.0 COG2271@1|root,COG2271@2|Bacteria,1MWYR@1224|Proteobacteria,2U1SE@28211|Alphaproteobacteria 28211|Alphaproteobacteria G Major facilitator Superfamily - - - - - - - - - - - - MFS_1 k59_977939_2 1122137.AQXF01000001_gene2985 7.68e-72 219.0 COG2166@1|root,COG2166@2|Bacteria,1RI8F@1224|Proteobacteria,2U9A2@28211|Alphaproteobacteria 28211|Alphaproteobacteria S SufE protein probably involved in Fe-S center assembly sufE - - ko:K02426 - - - - ko00000 - - - SufE k59_696252_1 1341679.P253_02704 4.23e-40 149.0 COG3677@1|root,COG3677@2|Bacteria,1N87H@1224|Proteobacteria,1RS9H@1236|Gammaproteobacteria,3NJX5@468|Moraxellaceae 1236|Gammaproteobacteria L Tn7-like transposition protein D - - - - - - - - - - - - TniQ,TnsD k59_244172_2 436308.Nmar_0401 1.58e-50 163.0 COG0200@1|root,arCOG00779@2157|Archaea,41SQY@651137|Thaumarchaeota 651137|Thaumarchaeota J Binds to the 23S rRNA rpl15 - - ko:K02876 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L27A k59_977946_1 42565.FP66_00270 1.71e-98 297.0 COG0206@1|root,COG0206@2|Bacteria,1MV2X@1224|Proteobacteria,1RPZS@1236|Gammaproteobacteria,1XIF2@135619|Oceanospirillales 135619|Oceanospirillales D Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity ftsZ - - ko:K03531 ko04112,map04112 - - - ko00000,ko00001,ko02048,ko03036,ko04812 - - - FtsZ_C,Tubulin k59_358023_1 572477.Alvin_1044 2.11e-157 481.0 COG0683@1|root,COG5001@1|root,COG0683@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RRQC@1236|Gammaproteobacteria,1WX34@135613|Chromatiales 135613|Chromatiales T Diguanylate cyclase - - - - - - - - - - - - BLUF,EAL,GGDEF,PAS,PAS_9,Peripla_BP_6 k59_358024_1 1122137.AQXF01000003_gene2140 3.63e-128 375.0 COG0626@1|root,COG0626@2|Bacteria,1MU57@1224|Proteobacteria,2TW14@28211|Alphaproteobacteria 28211|Alphaproteobacteria E COG0626 Cystathionine beta-lyases cystathionine gamma-synthases mdeA - 2.5.1.48,4.4.1.11 ko:K01739,ko:K01761 ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00270,map00450,map00920,map01100,map01110,map01130,map01230 M00017 R00654,R00999,R01288,R02508,R03217,R03260,R04770,R04944,R04945,R04946 RC00020,RC00056,RC00069,RC00196,RC00348,RC00420,RC01209,RC01210,RC02848,RC02866 ko00000,ko00001,ko00002,ko01000 - - - Cys_Met_Meta_PP k59_1600257_2 1127673.GLIP_2217 9.38e-07 53.5 COG0115@1|root,COG0115@2|Bacteria,1MZAK@1224|Proteobacteria,1RPPG@1236|Gammaproteobacteria,467J1@72275|Alteromonadaceae 1236|Gammaproteobacteria EH COG0115 Branched-chain amino acid aminotransferase 4-amino-4-deoxychorismate lyase pabC GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008696,GO:0009987,GO:0016829,GO:0016830,GO:0016833,GO:0019752,GO:0019842,GO:0030170,GO:0034641,GO:0036094,GO:0042558,GO:0043167,GO:0043168,GO:0043436,GO:0043603,GO:0044237,GO:0044281,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0070279,GO:0071704,GO:0097159,GO:1901360,GO:1901363,GO:1901564 4.1.3.38 ko:K02619 ko00790,map00790 - R05553 RC01843,RC02148 ko00000,ko00001,ko01000 - - iAPECO1_1312.APECO1_177,iE2348C_1286.E2348C_1188,iECED1_1282.ECED1_1239,iECNA114_1301.ECNA114_1153,iECOK1_1307.ECOK1_1203,iECS88_1305.ECS88_1110,iECSF_1327.ECSF_0995,iECUMN_1333.ECUMN_1273,iJN746.PP_1917,iPC815.YPO1603,iUMN146_1321.UM146_11845,iUTI89_1310.UTI89_C1222,ic_1306.c1366 Aminotran_4 k59_244184_1 309807.SRU_2062 1.66e-10 64.3 COG2202@1|root,COG2204@1|root,COG4191@1|root,COG2202@2|Bacteria,COG2204@2|Bacteria,COG4191@2|Bacteria,4PM6B@976|Bacteroidetes,1FIJK@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes T PAS fold - - - - - - - - - - - - HATPase_c,HisKA,Response_reg k59_244184_2 285514.JNWO01000008_gene2676 2.93e-16 77.4 COG0583@1|root,COG0583@2|Bacteria,2GNTF@201174|Actinobacteria 201174|Actinobacteria K Transcriptional regulator - - - - - - - - - - - - HTH_1,LysR_substrate k59_413757_1 1096930.L284_07930 7.29e-94 282.0 2E521@1|root,32ZVA@2|Bacteria,1RF95@1224|Proteobacteria,2U8QW@28211|Alphaproteobacteria,2K2DR@204457|Sphingomonadales 204457|Sphingomonadales S zinc-ribbon domain - - - - - - - - - - - - zinc_ribbon_4 k59_583173_2 314225.ELI_07740 4.68e-34 125.0 COG3216@1|root,COG3216@2|Bacteria,1RGV6@1224|Proteobacteria,2UB7Z@28211|Alphaproteobacteria,2K526@204457|Sphingomonadales 204457|Sphingomonadales S Uncharacterized protein conserved in bacteria (DUF2062) - - - ko:K09928 - - - - ko00000 - - - DUF2062 k59_639979_1 1125863.JAFN01000001_gene3302 5.9e-71 216.0 COG0197@1|root,COG0197@2|Bacteria,1RA0Z@1224|Proteobacteria,42QW5@68525|delta/epsilon subdivisions,2WP71@28221|Deltaproteobacteria 28221|Deltaproteobacteria J Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs rplP GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0097159,GO:1901363,GO:1990904 - ko:K02878 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L16 k59_639979_2 1125863.JAFN01000001_gene3303 5.37e-13 63.2 COG0255@1|root,COG0255@2|Bacteria,1Q1R3@1224|Proteobacteria,42WYX@68525|delta/epsilon subdivisions,2WSTS@28221|Deltaproteobacteria 28221|Deltaproteobacteria J Belongs to the universal ribosomal protein uL29 family rpmC GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - ko:K02904 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L29 k59_470315_1 1144305.PMI02_02252 2.14e-91 282.0 COG2124@1|root,COG2124@2|Bacteria,1MY5H@1224|Proteobacteria,2TTRR@28211|Alphaproteobacteria,2K2GN@204457|Sphingomonadales 204457|Sphingomonadales C cytochrome P450 - - - - - - - - - - - - p450 k59_1261051_1 1453496.AT03_20825 2.22e-60 201.0 COG1653@1|root,COG1653@2|Bacteria,1MVMW@1224|Proteobacteria,1RRH3@1236|Gammaproteobacteria 1236|Gammaproteobacteria G ABC transporter substrate-binding protein ugpB GO:0001407,GO:0005575,GO:0005623,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0015711,GO:0015748,GO:0015794,GO:0030288,GO:0030313,GO:0031975,GO:0034220,GO:0042597,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0098656,GO:1901264 - ko:K05813 ko02010,map02010 M00198 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.3 - iEcE24377_1341.EcE24377A_3931 SBP_bac_8 k59_413770_1 1125863.JAFN01000001_gene2677 1.99e-29 107.0 COG0636@1|root,COG0636@2|Bacteria,1NAIE@1224|Proteobacteria,42UFU@68525|delta/epsilon subdivisions,2WR59@28221|Deltaproteobacteria 28221|Deltaproteobacteria C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation - - - ko:K02110 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt_C k59_413770_2 1125863.JAFN01000001_gene2676 4.96e-24 96.7 COG0711@1|root,COG0711@2|Bacteria,1NA9K@1224|Proteobacteria,42VN2@68525|delta/epsilon subdivisions,2WR8C@28221|Deltaproteobacteria 28221|Deltaproteobacteria C Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) atpX - - ko:K02109 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt_B k59_244188_1 1265503.KB905166_gene839 3.95e-20 95.5 COG2866@1|root,COG2866@2|Bacteria,1R490@1224|Proteobacteria,1RYIE@1236|Gammaproteobacteria,2Q7MT@267889|Colwelliaceae 1236|Gammaproteobacteria E Zinc carboxypeptidase - - - - - - - - - - - - Peptidase_M14 k59_413771_1 1121423.JONT01000017_gene102 1.08e-72 230.0 COG0057@1|root,COG0057@2|Bacteria,1TNYU@1239|Firmicutes,247IZ@186801|Clostridia,260VU@186807|Peptococcaceae 186801|Clostridia G Belongs to the glyceraldehyde-3-phosphate dehydrogenase family gap - 1.2.1.12 ko:K00134 ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01061 RC00149 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - Gp_dh_C,Gp_dh_N k59_866730_1 1304275.C41B8_05778 2.65e-163 476.0 COG0651@1|root,COG0651@2|Bacteria,1MV6V@1224|Proteobacteria,1RQK5@1236|Gammaproteobacteria 1236|Gammaproteobacteria CP PFAM NADH Ubiquinone plastoquinone (complex I) - - - ko:K05568 - - - - ko00000,ko02000 2.A.63.1,2.A.63.2 - - Proton_antipo_M k59_866730_2 439235.Dalk_4925 2.11e-15 71.6 2EAIM@1|root,334MN@2|Bacteria,1Q4JY@1224|Proteobacteria,42XPC@68525|delta/epsilon subdivisions,2WT7M@28221|Deltaproteobacteria,2MPQQ@213118|Desulfobacterales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_866739_1 279714.FuraDRAFT_2461 1.6e-69 229.0 COG2812@1|root,COG2812@2|Bacteria,1MVCK@1224|Proteobacteria,2VIE0@28216|Betaproteobacteria,2KPX5@206351|Neisseriales 206351|Neisseriales L DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity dnaX - 2.7.7.7 ko:K02343 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_delta2,DNA_pol3_gamma3,DNA_pol3_tau_5 k59_1261054_1 1415778.JQMM01000001_gene2241 7.51e-114 347.0 COG0073@1|root,COG0143@1|root,COG0073@2|Bacteria,COG0143@2|Bacteria,1MUBY@1224|Proteobacteria,1RMYM@1236|Gammaproteobacteria,1J4VI@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation metG GO:0003674,GO:0003824,GO:0004812,GO:0004825,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006431,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.10 ko:K01874 ko00450,ko00970,map00450,map00970 M00359,M00360 R03659,R04773 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iEC042_1314.EC042_2346,iECUMN_1333.ECUMN_2446 Anticodon_1,tRNA-synt_1g,tRNA_bind k59_413774_1 1300345.LF41_2537 8.5e-23 90.9 COG2259@1|root,COG2259@2|Bacteria,1MZC7@1224|Proteobacteria,1SANJ@1236|Gammaproteobacteria,1X6YZ@135614|Xanthomonadales 135614|Xanthomonadales S GntR family transcriptional regulator - - - ko:K15977 - - - - ko00000 - - - DoxX k59_413774_2 398767.Glov_1187 1.55e-16 81.3 28K48@1|root,2Z9T8@2|Bacteria,1R4TF@1224|Proteobacteria,42MAD@68525|delta/epsilon subdivisions,2WKEM@28221|Deltaproteobacteria,43V42@69541|Desulfuromonadales 28221|Deltaproteobacteria S Domain of unknown function (DUF4405) - - - - - - - - - - - - DUF4405 k59_1204875_1 1437448.AZRT01000026_gene2079 6.29e-146 421.0 COG0842@1|root,COG0842@2|Bacteria,1MUIA@1224|Proteobacteria,2TU4P@28211|Alphaproteobacteria,1J294@118882|Brucellaceae 28211|Alphaproteobacteria V ABC-2 family transporter protein yhhJ - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_3 k59_1204879_1 278957.ABEA03000106_gene1824 5.79e-61 196.0 COG1556@1|root,COG1556@2|Bacteria,46TAQ@74201|Verrucomicrobia,3K821@414999|Opitutae 414999|Opitutae S LUD domain - - - ko:K00782 - - - - ko00000 - - - LUD_dom k59_1036486_2 337191.KTR9_4941 1.3e-44 157.0 COG0175@1|root,COG0175@2|Bacteria,2I5MS@201174|Actinobacteria 201174|Actinobacteria EH sulfate reduction - - - - - - - - - - - - - k59_1430548_1 876044.IMCC3088_811 4.13e-57 192.0 COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,1RMBQ@1236|Gammaproteobacteria,1J4DZ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Belongs to the aldehyde dehydrogenase family gabD - 1.2.1.16,1.2.1.20,1.2.1.79 ko:K00135 ko00250,ko00310,ko00350,ko00650,ko00760,ko01100,ko01120,map00250,map00310,map00350,map00650,map00760,map01100,map01120 M00027 R00713,R00714,R02401 RC00080 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_1374881_1 1229909.NSED_06615 3.04e-38 129.0 COG1522@1|root,arCOG01117@2157|Archaea,41T6G@651137|Thaumarchaeota 651137|Thaumarchaeota K Lrp/AsnC ligand binding domain - - - - - - - - - - - - AsnC_trans_reg k59_1374881_2 1229909.NSED_06610 7.26e-82 255.0 COG0513@1|root,arCOG00558@2157|Archaea,41SM1@651137|Thaumarchaeota 651137|Thaumarchaeota L DEAD DEAH box helicase - - 3.6.4.13 ko:K05592 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03009,ko03019 - - - DEAD,Helicase_C k59_977977_1 404589.Anae109_0647 3.35e-111 347.0 COG0643@1|root,COG0643@2|Bacteria,1MUAG@1224|Proteobacteria,42Y7C@68525|delta/epsilon subdivisions,2WTJH@28221|Deltaproteobacteria,2YXEJ@29|Myxococcales 28221|Deltaproteobacteria NT Chemotaxis protein histidine kinase and related kinases cheA2 - 2.7.13.3 ko:K03407 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 - - - CheW,H-kinase_dim,HATPase_c,Hpt k59_244208_1 666681.M301_2128 4.44e-51 170.0 COG1028@1|root,COG1028@2|Bacteria,1RHYX@1224|Proteobacteria,2VR0S@28216|Betaproteobacteria,2KKW7@206350|Nitrosomonadales 206350|Nitrosomonadales IQ PFAM short-chain dehydrogenase reductase SDR - - - - - - - - - - - - adh_short k59_866753_1 196367.JNFG01000203_gene378 3.85e-54 180.0 COG0549@1|root,COG0549@2|Bacteria,1MWXC@1224|Proteobacteria,2VM5W@28216|Betaproteobacteria,1K4E6@119060|Burkholderiaceae 28216|Betaproteobacteria E Belongs to the carbamate kinase family - - 2.7.2.2 ko:K00926 ko00220,ko00230,ko00910,ko01100,ko01120,ko01200,map00220,map00230,map00910,map01100,map01120,map01200 - R00150,R01395 RC00002,RC00043,RC02803,RC02804 ko00000,ko00001,ko01000 - - - AA_kinase k59_866753_2 196162.Noca_1631 6.11e-40 142.0 COG0540@1|root,COG0540@2|Bacteria,2GKNA@201174|Actinobacteria,4DV65@85009|Propionibacteriales 201174|Actinobacteria F Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain pyrB - 2.1.3.2 ko:K00609 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R01397 RC00064,RC02850 ko00000,ko00001,ko00002,ko01000 - - - OTCace,OTCace_N k59_1036512_1 745718.JADT01000008_gene3059 1.49e-84 259.0 COG2234@1|root,COG2234@2|Bacteria,4NEHY@976|Bacteroidetes,1HYWG@117743|Flavobacteriia 976|Bacteroidetes S Peptidase m28 - - - - - - - - - - - - Peptidase_M28 k59_254821_1 748658.KB907312_gene1695 3.54e-53 189.0 COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,1RN3H@1236|Gammaproteobacteria,1WWZ3@135613|Chromatiales 135613|Chromatiales KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance - - 2.7.6.5,3.1.7.2 ko:K01139 ko00230,map00230 - R00336,R00429 RC00002,RC00078 ko00000,ko00001,ko01000,ko03009 - - - ACT_4,HD_4,RelA_SpoT,TGS k59_369530_1 748658.KB907317_gene341 8.97e-57 183.0 COG0745@1|root,COG0745@2|Bacteria,1MY2Z@1224|Proteobacteria,1RN41@1236|Gammaproteobacteria,1WVZG@135613|Chromatiales 135613|Chromatiales T phosphate regulon transcriptional regulatory protein PhoB - - - ko:K07657 ko02020,map02020 M00434 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Trans_reg_C k59_1385926_4 292.DM42_5529 6.14e-12 64.7 COG0745@1|root,COG0745@2|Bacteria,1MY3D@1224|Proteobacteria,2VI0K@28216|Betaproteobacteria,1K24U@119060|Burkholderiaceae 28216|Betaproteobacteria KT response regulator - - - ko:K02483 - - - - ko00000,ko02022 - - - Response_reg,Trans_reg_C k59_707407_1 1487956.DR71_1569 6.75e-61 201.0 COG0183@1|root,COG0183@2|Bacteria,2GJAC@201174|Actinobacteria,22JVE@1653|Corynebacteriaceae 201174|Actinobacteria I Belongs to the thiolase family fadA3 - 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N k59_817516_2 580340.Tlie_0141 1.89e-61 204.0 COG0119@1|root,COG0119@2|Bacteria,3T9U1@508458|Synergistetes 508458|Synergistetes H Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) leuA - 2.3.3.13 ko:K01649 ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230 M00432 R01213 RC00004,RC00470,RC02754 br01601,ko00000,ko00001,ko00002,ko01000 - - - HMGL-like,LeuA_dimer k59_760755_1 314260.PB2503_00350 5.24e-73 245.0 COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,2TRWM@28211|Alphaproteobacteria 28211|Alphaproteobacteria P Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_1047333_1 221288.JH992901_gene2523 2.13e-33 139.0 COG2199@1|root,COG2203@1|root,COG2199@2|Bacteria,COG2203@2|Bacteria,1GQQT@1117|Cyanobacteria 1117|Cyanobacteria T Diguanylate cyclase phosphodiesterase with PAS PAC sensor(S) - - - - - - - - - - - - EAL,GGDEF,PAS,PAS_4,Response_reg k59_707421_1 1121887.AUDK01000018_gene3280 2.26e-109 331.0 COG3507@1|root,COG3507@2|Bacteria,4NIHD@976|Bacteroidetes,1I86D@117743|Flavobacteriia,2NTQQ@237|Flavobacterium 976|Bacteroidetes G Belongs to the glycosyl hydrolase 43 family - - 3.2.1.99 ko:K06113 - - - - ko00000,ko01000 - GH43 - GH43_C,Glyco_hydro_43 k59_533812_1 1209072.ALBT01000051_gene532 3.69e-37 131.0 COG0558@1|root,COG0558@2|Bacteria,1RCZ7@1224|Proteobacteria,1S465@1236|Gammaproteobacteria,1FGRZ@10|Cellvibrio 1236|Gammaproteobacteria I CDP-alcohol phosphatidyltransferase pgsA GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006629,GO:0006644,GO:0006650,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008444,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016020,GO:0016021,GO:0016740,GO:0016772,GO:0016780,GO:0017169,GO:0019637,GO:0031224,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044425,GO:0044464,GO:0045017,GO:0046474,GO:0046486,GO:0071704,GO:0071944,GO:0090407,GO:1901576 2.7.8.41,2.7.8.5 ko:K00995,ko:K08744 ko00564,ko01100,map00564,map01100 - R01801,R02030 RC00002,RC00017,RC02795 ko00000,ko00001,ko01000 - - iAF1260.b1912,iAPECO1_1312.APECO1_954,iB21_1397.B21_01866,iBWG_1329.BWG_1721,iE2348C_1286.E2348C_2030,iEC042_1314.EC042_2073,iEC55989_1330.EC55989_2132,iECABU_c1320.ECABU_c21710,iECBD_1354.ECBD_1731,iECB_1328.ECB_01877,iECDH10B_1368.ECDH10B_2053,iECDH1ME8569_1439.ECDH1ME8569_1852,iECD_1391.ECD_01877,iECED1_1282.ECED1_2177,iECH74115_1262.ECH74115_2684,iECIAI1_1343.ECIAI1_1996,iECIAI39_1322.ECIAI39_1143,iECNA114_1301.ECNA114_2003,iECO103_1326.ECO103_2168,iECO111_1330.ECO111_2492,iECO26_1355.ECO26_2804,iECOK1_1307.ECOK1_2029,iECP_1309.ECP_1852,iECS88_1305.ECS88_1966,iECSF_1327.ECSF_1764,iECSP_1301.ECSP_2516,iECUMN_1333.ECUMN_2204,iECs_1301.ECs2650,iETEC_1333.ETEC_2020,iEcDH1_1363.EcDH1_1734,iEcE24377_1341.EcE24377A_2145,iEcHS_1320.EcHS_A2010,iEcSMS35_1347.EcSMS35_1271,iEcolC_1368.EcolC_1727,iG2583_1286.G2583_2363,iJO1366.b1912,iJR904.b1912,iLF82_1304.LF82_1635,iNRG857_1313.NRG857_09550,iSDY_1059.SDY_1106,iSSON_1240.SSON_1206,iSbBS512_1146.SbBS512_E1039,iUMN146_1321.UM146_07620,iUMNK88_1353.UMNK88_2386,iUTI89_1310.UTI89_C2113,iY75_1357.Y75_RS10025,iYL1228.KPN_02410,iZ_1308.Z3000,ic_1306.c2325 CDP-OH_P_transf k59_1556089_1 1242864.D187_000788 4.02e-45 158.0 COG1398@1|root,COG1398@2|Bacteria,1N2MA@1224|Proteobacteria,42YFC@68525|delta/epsilon subdivisions,2WU03@28221|Deltaproteobacteria,2YUBP@29|Myxococcales 28221|Deltaproteobacteria I desaturase - - 1.14.19.1 ko:K00507 ko01040,ko01212,ko03320,ko04152,ko04212,map01040,map01212,map03320,map04152,map04212 - R02222 RC00917 ko00000,ko00001,ko01000,ko01004 - - - FA_desaturase k59_986332_1 999541.bgla_2g03610 3.53e-90 283.0 COG0402@1|root,COG0402@2|Bacteria,1MUFE@1224|Proteobacteria,2VH0A@28216|Betaproteobacteria,1K3SR@119060|Burkholderiaceae 28216|Betaproteobacteria F Formiminoglutamate deiminase hutF - 3.5.3.13 ko:K05603 ko00340,map00340 - R02286 RC00682 ko00000,ko00001,ko01000 - - - Amidohydro_1 k59_648155_2 1415778.JQMM01000001_gene357 1.27e-27 110.0 COG3178@1|root,COG3178@2|Bacteria,1MXCH@1224|Proteobacteria,1RQ1Q@1236|Gammaproteobacteria,1J50Q@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S related to Ser Thr protein kinases - GO:0000166,GO:0000270,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005975,GO:0006022,GO:0006040,GO:0006082,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009254,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0017076,GO:0019200,GO:0019752,GO:0030203,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0046835,GO:0071704,GO:0097159,GO:0097172,GO:0097367,GO:1901135,GO:1901265,GO:1901363,GO:1901564 2.7.1.221 ko:K07102 ko00520,ko01100,map00520,map01100 - R08968,R11024 RC00002,RC00078 ko00000,ko00001,ko01000 - - - APH k59_30059_1 644282.Deba_0889 1.42e-69 225.0 COG0195@1|root,COG0195@2|Bacteria,1MWT7@1224|Proteobacteria,42MUW@68525|delta/epsilon subdivisions,2WIXI@28221|Deltaproteobacteria 28221|Deltaproteobacteria K Participates in both transcription termination and antitermination nusA - - ko:K02600 - - - - ko00000,ko03009,ko03021 - - - HHH_5,KH_5,NusA_N,S1 k59_1158004_2 1267535.KB906767_gene2521 3.48e-09 55.5 294EW@1|root,2ZRUR@2|Bacteria,3Y5CG@57723|Acidobacteria 57723|Acidobacteria S Protein of unknown function (DUF1569) - - - - - - - - - - - - DUF1569 k59_1556100_1 378806.STAUR_2110 1.46e-112 343.0 COG2262@1|root,COG2262@2|Bacteria,1MUA0@1224|Proteobacteria,42NA6@68525|delta/epsilon subdivisions,2WIMU@28221|Deltaproteobacteria,2YU9T@29|Myxococcales 28221|Deltaproteobacteria S GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis hflX - - ko:K03665 - - - - ko00000,ko03009 - - - GTP-bdg_M,GTP-bdg_N,MMR_HSR1 k59_197203_1 1122137.AQXF01000006_gene684 1.1e-12 67.0 COG1868@1|root,COG1868@2|Bacteria,1MX01@1224|Proteobacteria,2TR4F@28211|Alphaproteobacteria 28211|Alphaproteobacteria N FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation fliM - - ko:K02416 ko02030,ko02040,map02030,map02040 - - - ko00000,ko00001,ko02035 - - - FliM,FliMN_C k59_197203_2 1122137.AQXF01000006_gene683 5.62e-31 114.0 2DT9H@1|root,33JBF@2|Bacteria,1NJYZ@1224|Proteobacteria,2UN13@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_1215783_1 365046.Rta_22810 1.73e-58 194.0 COG0845@1|root,COG0845@2|Bacteria,1N97Q@1224|Proteobacteria,2VIES@28216|Betaproteobacteria,4AHNX@80864|Comamonadaceae 28216|Betaproteobacteria M Biotin-lipoyl like - - - - - - - - - - - - Biotin_lipoyl_2,HlyD_3 k59_1215783_2 930166.CD58_17485 3.01e-20 89.7 COG0845@1|root,COG1994@1|root,COG0845@2|Bacteria,COG1994@2|Bacteria,1MW9I@1224|Proteobacteria,1RRTY@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Peptidase M50 - - - ko:K16922 - - - - ko00000,ko01002 - - - Biotin_lipoyl_2,HlyD_3 k59_369578_1 1121396.KB892921_gene66 1.28e-11 74.7 COG2202@1|root,COG3275@1|root,COG4191@1|root,COG4936@1|root,COG2202@2|Bacteria,COG3275@2|Bacteria,COG4191@2|Bacteria,COG4936@2|Bacteria,1RCM9@1224|Proteobacteria,42PKS@68525|delta/epsilon subdivisions,2WKCD@28221|Deltaproteobacteria,2MPM3@213118|Desulfobacterales 28221|Deltaproteobacteria T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,PocR,sCache_2 k59_1724154_1 1122137.AQXF01000001_gene3259 2.66e-222 621.0 COG3420@1|root,COG3420@2|Bacteria,1QUPB@1224|Proteobacteria,2TTFV@28211|Alphaproteobacteria 28211|Alphaproteobacteria P Periplasmic copper-binding protein (NosD) - - - - - - - - - - - - Beta_helix k59_1724154_2 1189612.A33Q_2206 1.68e-56 192.0 COG2010@1|root,COG2010@2|Bacteria,4PMQB@976|Bacteroidetes,47YEI@768503|Cytophagia 976|Bacteroidetes C Cytochrome c - - - - - - - - - - - - - k59_707453_1 744979.R2A130_1495 5.76e-50 174.0 COG0683@1|root,COG0683@2|Bacteria,1MWR8@1224|Proteobacteria,2UQXU@28211|Alphaproteobacteria 28211|Alphaproteobacteria E COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component MA20_19420 - - ko:K01999 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - Peripla_BP_6 k59_422909_1 279714.FuraDRAFT_2724 7.81e-45 166.0 COG1404@1|root,COG3506@1|root,COG1404@2|Bacteria,COG3506@2|Bacteria,1MU3S@1224|Proteobacteria,2VWI8@28216|Betaproteobacteria 28216|Betaproteobacteria O Subtilase family - - - - - - - - - - - - Peptidase_S8 k59_30084_1 572477.Alvin_1073 2.29e-78 261.0 COG0247@1|root,COG0277@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,1MU43@1224|Proteobacteria,1RMRH@1236|Gammaproteobacteria,1WWYS@135613|Chromatiales 135613|Chromatiales C FAD linked - - - - - - - - - - - - CCG,DUF3400,DUF3683,FAD-oxidase_C,FAD_binding_4,Fer4_8 k59_1499351_1 377629.TERTU_2279 3.41e-65 226.0 COG0577@1|root,COG0577@2|Bacteria,1NREW@1224|Proteobacteria,1RPKB@1236|Gammaproteobacteria,2PPVJ@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria V MacB-like periplasmic core domain - - - - - - - - - - - - FtsX,MacB_PCD k59_986352_1 215803.DB30_0442 2.64e-98 304.0 COG3387@1|root,COG3387@2|Bacteria,1MV08@1224|Proteobacteria,42QCJ@68525|delta/epsilon subdivisions,2WKE7@28221|Deltaproteobacteria,2YUF8@29|Myxococcales 28221|Deltaproteobacteria G Glycosyl hydrolases family 15 - - - - - - - - - - - - DUF547,Glyco_hydro_15 k59_1158029_1 1003200.AXXA_15347 0.000519 42.4 COG3181@1|root,COG3181@2|Bacteria,1NTSS@1224|Proteobacteria,2W1PH@28216|Betaproteobacteria 28216|Betaproteobacteria S Tripartite tricarboxylate transporter family receptor - - - - - - - - - - - - TctC k59_1158029_2 864051.BurJ1DRAFT_3909 4.54e-14 71.2 COG2721@1|root,COG2721@2|Bacteria,1MU9V@1224|Proteobacteria,2VHJB@28216|Betaproteobacteria,1KJ14@119065|unclassified Burkholderiales 28216|Betaproteobacteria G D-galactarate dehydratase Altronate hydrolase uxaA - 4.2.1.7,4.4.1.24 ko:K01685,ko:K16846 ko00040,ko00270,ko01100,map00040,map00270,map01100 M00631 R01540,R07633 RC00543,RC01785 ko00000,ko00001,ko00002,ko01000 - - - GD_AH_C,SAF k59_1556128_1 984262.SGRA_2150 4.48e-76 234.0 COG0778@1|root,COG0778@2|Bacteria,4NFJK@976|Bacteroidetes 976|Bacteroidetes C Nitroreductase family - - - - - - - - - - - - Nitroreductase k59_707470_1 377629.TERTU_3013 2.38e-130 379.0 COG0150@1|root,COG0150@2|Bacteria,1MURG@1224|Proteobacteria,1RNZZ@1236|Gammaproteobacteria,2PMV3@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria F AIR synthase related protein, N-terminal domain purM GO:0003674,GO:0003824,GO:0004641,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016882,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.3.1 ko:K01933 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04208 RC01100 ko00000,ko00001,ko00002,ko01000 - - iECSF_1327.ECSF_2340 AIRS,AIRS_C k59_312791_1 702113.PP1Y_AT25218 8.61e-82 245.0 COG0193@1|root,COG0193@2|Bacteria,1MX1P@1224|Proteobacteria,2TT6Q@28211|Alphaproteobacteria,2K0UK@204457|Sphingomonadales 204457|Sphingomonadales J The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis pth - 3.1.1.29 ko:K01056 - - - - ko00000,ko01000,ko03012 - - - Pept_tRNA_hydro k59_312791_2 1088721.NSU_4393 3.42e-22 91.7 COG1825@1|root,COG1825@2|Bacteria,1RDH0@1224|Proteobacteria,2U5P0@28211|Alphaproteobacteria,2K122@204457|Sphingomonadales 204457|Sphingomonadales J This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance ctc - - ko:K02897 ko03010,map03010 M00178 - - ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L25p,Ribosomal_TL5_C k59_594231_1 1380394.JADL01000010_gene4306 3.48e-56 188.0 COG0001@1|root,COG0001@2|Bacteria,1MUY5@1224|Proteobacteria,2U3S7@28211|Alphaproteobacteria,2JR3P@204441|Rhodospirillales 204441|Rhodospirillales H Aminotransferase class-III - - - - - - - - - - - - Aminotran_3 k59_594242_1 158500.BV97_02580 8.75e-101 306.0 COG0770@1|root,COG0770@2|Bacteria,1QTSF@1224|Proteobacteria,2TR0Q@28211|Alphaproteobacteria,2K1N2@204457|Sphingomonadales 204457|Sphingomonadales M Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein murF - 6.3.2.10 ko:K01929 ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502 - R04573,R04617 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_1438880_1 1144305.PMI02_02788 2.76e-102 307.0 COG1364@1|root,COG1364@2|Bacteria,1MU0T@1224|Proteobacteria,2TS98@28211|Alphaproteobacteria,2K035@204457|Sphingomonadales 204457|Sphingomonadales E Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate argJ - 2.3.1.1,2.3.1.35 ko:K00620 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028 R00259,R02282 RC00004,RC00064 ko00000,ko00001,ko00002,ko01000 - - - ArgJ k59_369629_1 323850.Shew_1852 5.71e-62 214.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,2QA13@267890|Shewanellaceae 1236|Gammaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family acrF - - ko:K18138 ko01501,ko01503,map01501,map01503 M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000 2.A.6.2 - - ACR_tran k59_254913_2 443144.GM21_3395 1.81e-39 146.0 COG0615@1|root,COG2870@1|root,COG0615@2|Bacteria,COG2870@2|Bacteria,1MV3Z@1224|Proteobacteria,42MBC@68525|delta/epsilon subdivisions,2WIKU@28221|Deltaproteobacteria,43TN4@69541|Desulfuromonadales 28221|Deltaproteobacteria F Catalyzes the phosphorylation of D-glycero-D-manno- heptose 7-phosphate at the C-1 position to selectively form D- glycero-beta-D-manno-heptose-1,7-bisphosphate hldE GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0006629,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0008713,GO:0008920,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016301,GO:0016310,GO:0016740,GO:0016757,GO:0016772,GO:0019200,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0046401,GO:0046835,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 2.7.1.167,2.7.7.70 ko:K03272 ko00540,ko01100,map00540,map01100 M00064 R05644,R05646 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000,ko01005 - - iAF987.Gmet_0922 CTP_transf_like,PfkB k59_254913_3 518766.Rmar_2551 8.34e-110 328.0 COG0714@1|root,COG0714@2|Bacteria,4NDVZ@976|Bacteroidetes,1FITR@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes S ATPase family associated with various cellular activities (AAA) moxR - - ko:K03924 - - - - ko00000,ko01000 - - - AAA_3 k59_254913_4 1304872.JAGC01000009_gene103 9.16e-21 92.8 COG1721@1|root,COG1721@2|Bacteria,1Q7RR@1224|Proteobacteria,42PJB@68525|delta/epsilon subdivisions,2WK1X@28221|Deltaproteobacteria,2MAI0@213115|Desulfovibrionales 28221|Deltaproteobacteria S Protein of unknown function DUF58 - - - - - - - - - - - - DUF58 k59_1158066_2 1000565.METUNv1_03841 1.26e-32 120.0 COG3279@1|root,COG3279@2|Bacteria,1MUE8@1224|Proteobacteria,2WEFP@28216|Betaproteobacteria,2M03Q@206389|Rhodocyclales 206389|Rhodocyclales K Alginate biosynthesis regulatory protein AlgR - - - ko:K08083 ko02020,map02020 M00493 - - ko00000,ko00001,ko00002,ko02022 - - - LytTR,Response_reg k59_1776944_1 555793.WSK_1474 1.95e-108 329.0 COG2234@1|root,COG2234@2|Bacteria,1MV86@1224|Proteobacteria,2TVJ5@28211|Alphaproteobacteria,2K04D@204457|Sphingomonadales 204457|Sphingomonadales S Peptidase, M28 - - - - - - - - - - - - PA,Peptidase_M28 k59_877951_1 91464.S7335_4522 4.3e-29 117.0 COG4424@1|root,COG4424@2|Bacteria 2|Bacteria S carbohydrate metabolic process - - - - - - - - - - - - Sulfotransfer_1,Sulfotransfer_3 k59_1499416_1 667014.Thein_1286 2.36e-83 280.0 COG0653@1|root,COG0653@2|Bacteria,2GGR1@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane secA - - ko:K03070 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4 - - Helicase_C,SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW k59_1499416_2 1123508.JH636442_gene3884 7.29e-14 72.8 COG1364@1|root,COG1364@2|Bacteria,2IWVM@203682|Planctomycetes 203682|Planctomycetes E Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate argJ GO:0003674,GO:0003824,GO:0004042,GO:0004358,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006592,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.3.1.1,2.3.1.35 ko:K00620 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028 R00259,R02282 RC00004,RC00064 ko00000,ko00001,ko00002,ko01000 - - - ArgJ k59_30156_1 1177179.A11A3_08670 4.08e-67 215.0 COG0263@1|root,COG0263@2|Bacteria,1MUBG@1224|Proteobacteria,1RM7X@1236|Gammaproteobacteria,1XI4K@135619|Oceanospirillales 135619|Oceanospirillales E Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate proB - 2.7.2.11 ko:K00931 ko00330,ko00332,ko01100,ko01130,ko01230,map00330,map00332,map01100,map01130,map01230 M00015 R00239 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase,PUA k59_369667_1 506534.Rhein_3855 1.47e-14 78.6 COG1629@1|root,COG1629@2|Bacteria,COG4771@2|Bacteria,1MU9K@1224|Proteobacteria,1RNBD@1236|Gammaproteobacteria 1236|Gammaproteobacteria P COG1629 Outer membrane receptor proteins, mostly Fe transport - - - - - - - - - - - - Plug,TonB_dep_Rec k59_1438907_1 59538.XP_005959125.1 3.61e-65 224.0 COG0443@1|root,KOG0102@2759|Eukaryota,38EJA@33154|Opisthokonta,3BABY@33208|Metazoa,3CT5K@33213|Bilateria,48BEX@7711|Chordata,48XVF@7742|Vertebrata,3JAJ8@40674|Mammalia,4IZNM@91561|Cetartiodactyla 33154|Opisthokonta O Heat shock 70 kDa protein - - - - - - - - - - - - HSP70 k59_197294_2 1415778.JQMM01000001_gene801 4.23e-74 225.0 COG0054@1|root,COG0054@2|Bacteria,1RD9J@1224|Proteobacteria,1S3WD@1236|Gammaproteobacteria,1J5Y6@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin ribH GO:0000906,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.78 ko:K00794 ko00740,ko01100,ko01110,map00740,map01100,map01110 M00125 R04457 RC00960 ko00000,ko00001,ko00002,ko01000 - - iSFV_1184.SFV_0380 DMRL_synthase k59_1724208_1 1415755.JQLV01000001_gene3278 3.59e-35 122.0 COG2329@1|root,COG2329@2|Bacteria,1MZKW@1224|Proteobacteria,1S9N8@1236|Gammaproteobacteria,1XKXM@135619|Oceanospirillales 135619|Oceanospirillales S Antibiotic biosynthesis monooxygenase - - - - - - - - - - - - ABM k59_312855_1 1121004.ATVC01000015_gene2108 3.98e-79 260.0 COG2609@1|root,COG2609@2|Bacteria,1MV21@1224|Proteobacteria,2VIAH@28216|Betaproteobacteria,2KPJE@206351|Neisseriales 206351|Neisseriales C Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) aceE - 1.2.4.1 ko:K00163 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200 M00307 R00014,R00209,R01699,R03270 RC00004,RC00027,RC00627,RC02742,RC02744,RC02882 br01601,ko00000,ko00001,ko00002,ko01000 - - - Transketolase_N k59_1215887_1 377629.TERTU_3485 1.86e-102 328.0 COG0439@1|root,COG1984@1|root,COG2049@1|root,COG0439@2|Bacteria,COG1984@2|Bacteria,COG2049@2|Bacteria,1MU4H@1224|Proteobacteria,1T1GN@1236|Gammaproteobacteria,2PMW8@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria EI Pfam:AHS1 uca - 6.3.4.6 ko:K01941 ko00220,ko00791,ko01100,map00220,map00791,map01100 - R00774 RC00378 ko00000,ko00001,ko01000 - - - Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2,CT_A_B,CT_C_D k59_1100553_1 1121920.AUAU01000017_gene1239 4.34e-70 230.0 COG0281@1|root,COG0281@2|Bacteria,3Y43V@57723|Acidobacteria 57723|Acidobacteria C Malic enzyme, NAD binding domain - - 1.1.1.38 ko:K00027 ko00620,ko01200,ko02020,map00620,map01200,map02020 - R00214 RC00105 ko00000,ko00001,ko01000 - - - Malic_M,malic k59_1499432_1 298655.KI912267_gene7359 1.41e-99 317.0 COG2609@1|root,COG2609@2|Bacteria,2GJRE@201174|Actinobacteria,4ESAA@85013|Frankiales 201174|Actinobacteria C Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) aceE - 1.2.4.1 ko:K00163 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200 M00307 R00014,R00209,R01699,R03270 RC00004,RC00027,RC00627,RC02742,RC02744,RC02882 br01601,ko00000,ko00001,ko00002,ko01000 - - - Transketolase_N k59_1724215_1 491952.Mar181_1935 8.86e-64 216.0 COG0326@1|root,COG0326@2|Bacteria,1MUUE@1224|Proteobacteria,1RNWD@1236|Gammaproteobacteria,1XHR3@135619|Oceanospirillales 135619|Oceanospirillales O Molecular chaperone. Has ATPase activity htpG - - ko:K04079 ko04141,ko04151,ko04217,ko04612,ko04621,ko04626,ko04657,ko04659,ko04914,ko04915,ko05200,ko05215,ko05418,map04141,map04151,map04217,map04612,map04621,map04626,map04657,map04659,map04914,map04915,map05200,map05215,map05418 - - - ko00000,ko00001,ko01009,ko03029,ko03051,ko03110,ko04131,ko04147 - - - HATPase_c,HATPase_c_3,HSP90 k59_197309_1 314285.KT71_15269 5.45e-17 81.3 COG0457@1|root,COG0457@2|Bacteria,1MVMG@1224|Proteobacteria,1RU5N@1236|Gammaproteobacteria,1J8CG@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Sulfotransferase domain - - - - - - - - - - - - Sulfotransfer_3,TPR_16,TPR_19,TPR_8 k59_197309_2 1283284.AZUK01000001_gene2587 1.24e-74 237.0 COG0160@1|root,COG0160@2|Bacteria,1MWY6@1224|Proteobacteria,1RMP0@1236|Gammaproteobacteria,1Y3PW@135624|Aeromonadales 135624|Aeromonadales E Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family gabT - 2.6.1.19,2.6.1.22 ko:K07250 ko00250,ko00280,ko00410,ko00640,ko00650,ko01100,ko01120,map00250,map00280,map00410,map00640,map00650,map01100,map01120 M00027 R00908,R01648,R04188 RC00006,RC00062,RC00160 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 k59_648253_1 326297.Sama_1023 6.58e-28 113.0 COG1030@1|root,COG1030@2|Bacteria,1MUJN@1224|Proteobacteria,1RN3U@1236|Gammaproteobacteria,2QANM@267890|Shewanellaceae 1236|Gammaproteobacteria O NfeD-like C-terminal, partner-binding nfeD - - ko:K07403 - - - - ko00000 - - - NfeD k59_707552_1 710111.FraQA3DRAFT_6425 8.19e-19 89.7 COG0438@1|root,COG0438@2|Bacteria,2GM6D@201174|Actinobacteria,4ERSX@85013|Frankiales 201174|Actinobacteria M PFAM Glycosyl transferase, group 1 pimB GO:0000009,GO:0000030,GO:0003674,GO:0003824,GO:0004376,GO:0005575,GO:0005623,GO:0005886,GO:0006629,GO:0006643,GO:0006664,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009247,GO:0009987,GO:0016020,GO:0016740,GO:0016757,GO:0016758,GO:0033164,GO:0040007,GO:0043750,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044464,GO:0046467,GO:0070085,GO:0071704,GO:0071944,GO:0097502,GO:1901135,GO:1901137,GO:1901576,GO:1903509 2.4.1.346 ko:K13668 - - R11703,R11704 - ko00000,ko01000,ko01003 - GT4 - Glyco_transf_4,Glycos_transf_1 k59_142127_1 1249997.JHZW01000002_gene344 4.69e-16 81.3 290I6@1|root,2ZN71@2|Bacteria,4NM5S@976|Bacteroidetes,1I19E@117743|Flavobacteriia,2PHDJ@252356|Maribacter 976|Bacteroidetes - - - - - - - - - - - - - - - k59_312875_1 395493.BegalDRAFT_0278 4.15e-75 240.0 COG0459@1|root,COG0459@2|Bacteria,1MURR@1224|Proteobacteria,1RMTB@1236|Gammaproteobacteria,4600M@72273|Thiotrichales 72273|Thiotrichales O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions groL - - ko:K04077 ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 - - - Cpn60_TCP1 k59_1440140_2 768671.ThimaDRAFT_3398 2.1e-65 204.0 COG3751@1|root,COG3751@2|Bacteria,1RBXB@1224|Proteobacteria,1RR8W@1236|Gammaproteobacteria,1WWUG@135613|Chromatiales 135613|Chromatiales O 2OG-Fe(II) oxygenase superfamily - - - - - - - - - - - - 2OG-FeII_Oxy_3 k59_31699_1 502025.Hoch_0273 7e-75 227.0 COG2080@1|root,COG2080@2|Bacteria,1RD8C@1224|Proteobacteria,42SQU@68525|delta/epsilon subdivisions,2WPRP@28221|Deltaproteobacteria,2YUSU@29|Myxococcales 28221|Deltaproteobacteria C [2Fe-2S] binding domain - - 1.3.99.16 ko:K07302 - - - - ko00000,ko01000 - - - Fer2,Fer2_2 k59_595951_1 1117647.M5M_19155 1.76e-62 211.0 COG0329@1|root,COG0379@1|root,COG0329@2|Bacteria,COG0379@2|Bacteria,1MWQU@1224|Proteobacteria,1RMFS@1236|Gammaproteobacteria,1J56G@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate nadA GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006734,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008987,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016053,GO:0017144,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0019805,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046496,GO:0046874,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.5.1.72 ko:K03517 ko00760,ko01100,map00760,map01100 M00115 R04292 RC01119 ko00000,ko00001,ko00002,ko01000 - - iAF1260.b0750,iAPECO1_1312.APECO1_1338,iB21_1397.B21_00692,iBWG_1329.BWG_0602,iECBD_1354.ECBD_2917,iECB_1328.ECB_00703,iECDH10B_1368.ECDH10B_0817,iECDH1ME8569_1439.ECDH1ME8569_0703,iECD_1391.ECD_00703,iECED1_1282.ECED1_0711,iECOK1_1307.ECOK1_0750,iECP_1309.ECP_0761,iECS88_1305.ECS88_0766,iECSP_1301.ECSP_0802,iECs_1301.ECs0778,iETEC_1333.ETEC_0754,iEcDH1_1363.EcDH1_2892,iEcolC_1368.EcolC_2912,iJN746.PP_1231,iJO1366.b0750,iJR904.b0750,iUMN146_1321.UM146_13905,iUTI89_1310.UTI89_C0747,iY75_1357.Y75_RS03905,iZ_1308.Z0919 NadA k59_595951_2 1049564.TevJSym_ax00210 3.38e-55 179.0 COG2716@1|root,COG2716@2|Bacteria,1R7W7@1224|Proteobacteria,1RSDP@1236|Gammaproteobacteria,1JBWT@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E ACT domain gcvR GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576 - ko:K03567 ko02026,map02026 - - - ko00000,ko00001,ko03000 - - - ACT,ACT_6 k59_1777958_2 1232410.KI421424_gene1794 5.48e-51 175.0 COG1007@1|root,COG1007@2|Bacteria,1MV56@1224|Proteobacteria,42P7Z@68525|delta/epsilon subdivisions,2WK06@28221|Deltaproteobacteria,43TSP@69541|Desulfuromonadales 28221|Deltaproteobacteria C Proton-conducting membrane transporter nuoN - 1.6.5.3 ko:K00343 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Proton_antipo_M k59_595961_1 1458427.BAWN01000012_gene705 4.85e-102 316.0 COG1924@1|root,COG1924@2|Bacteria,1PKG6@1224|Proteobacteria,2WE9S@28216|Betaproteobacteria 28216|Betaproteobacteria I BadF/BadG/BcrA/BcrD ATPase family - - - - - - - - - - - - BcrAD_BadFG,DUF2229,HGD-D k59_761974_1 313603.FB2170_10126 4.82e-92 294.0 COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,4NEHE@976|Bacteroidetes,1HY80@117743|Flavobacteriia 976|Bacteroidetes G Belongs to the PEP-utilizing enzyme family ppdK - 2.7.9.1 ko:K01006 ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200 M00169,M00171,M00172,M00173 R00206 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - PEP-utilizers,PEP-utilizers_C,PPDK_N k59_1676852_1 526222.Desal_2534 8.32e-54 186.0 COG1283@1|root,COG1283@2|Bacteria,1MUDE@1224|Proteobacteria,42PW9@68525|delta/epsilon subdivisions,2WJTI@28221|Deltaproteobacteria,2M9TB@213115|Desulfovibrionales 28221|Deltaproteobacteria P PFAM Na Pi-cotransporter - - - ko:K03324 - - - - ko00000,ko02000 2.A.58.2 - - Na_Pi_cotrans,PhoU k59_1676852_2 1366050.N234_19850 2.58e-29 109.0 COG0346@1|root,COG0346@2|Bacteria,1RHD4@1224|Proteobacteria,2VSJM@28216|Betaproteobacteria,1K7MX@119060|Burkholderiaceae 28216|Betaproteobacteria E PFAM Glyoxalase bleomycin resistance protein dioxygenase - - - ko:K08234 - - - - ko00000 - - - Glyoxalase k59_1786904_1 382640.BT_0703 4e-19 85.5 COG3088@1|root,COG3088@2|Bacteria,1MZZ5@1224|Proteobacteria,2U96P@28211|Alphaproteobacteria,48U3D@772|Bartonellaceae 28211|Alphaproteobacteria P subunit of a heme lyase cycL - - ko:K02200 - - - - ko00000 - - - CcmH k59_1450344_1 1229909.NSED_09085 1.33e-67 209.0 COG0125@1|root,arCOG01891@2157|Archaea,41T33@651137|Thaumarchaeota 651137|Thaumarchaeota F thymidylate kinase tmk - 2.7.4.9 ko:K00943 ko00240,ko01100,map00240,map01100 M00053 R02094,R02098 RC00002 ko00000,ko00001,ko00002,ko01000 - - - Thymidylate_kin k59_771628_1 298655.KI912266_gene4277 9.08e-19 81.3 COG0640@1|root,COG0640@2|Bacteria,2ISNZ@201174|Actinobacteria 201174|Actinobacteria K transcriptional - - - - - - - - - - - - HTH_20,HTH_5 k59_771628_2 247490.KSU1_C0202 1.88e-34 129.0 COG0330@1|root,COG0330@2|Bacteria 2|Bacteria O stress-induced mitochondrial fusion hflC GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 - - - - - - - - - - Band_7 k59_720678_1 1122137.AQXF01000001_gene3241 7.64e-38 134.0 COG3208@1|root,COG3208@2|Bacteria 2|Bacteria Q Thioesterase involved in non-ribosomal peptide biosynthesis bioH - 3.1.1.85 ko:K02170 ko00780,ko01100,map00780,map01100 M00572 R09725 RC00460,RC00461 ko00000,ko00001,ko00002,ko01000 - - - Abhydrolase_1,Abhydrolase_6 k59_720678_2 1122137.AQXF01000001_gene3240 6.73e-56 183.0 COG0604@1|root,COG0604@2|Bacteria,1MWBD@1224|Proteobacteria,2TS3Z@28211|Alphaproteobacteria 28211|Alphaproteobacteria C COG0604 NADPH quinone reductase and related Zn-dependent oxidoreductases qor - 1.6.5.5 ko:K00344 - - - - ko00000,ko01000 - - - ADH_N,ADH_zinc_N k59_1511804_1 1246459.KB898362_gene3303 8.91e-06 47.0 COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,2TS2I@28211|Alphaproteobacteria,4BAED@82115|Rhizobiaceae 28211|Alphaproteobacteria F Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen nrdJ - 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - Ribonuc_red_2_N,Ribonuc_red_lgC k59_1786925_1 1134474.O59_001303 4.96e-106 311.0 COG2022@1|root,COG2022@2|Bacteria,1N0N5@1224|Proteobacteria,1RMPD@1236|Gammaproteobacteria,1FGK5@10|Cellvibrio 1236|Gammaproteobacteria H Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S thiG GO:0003674,GO:0003824,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.8.1.10 ko:K03149 ko00730,ko01100,map00730,map01100 - R10247 RC03096,RC03097,RC03461 ko00000,ko00001,ko01000 - - - ThiG k59_1676875_1 439496.RBY4I_2937 7.61e-24 103.0 COG0405@1|root,COG0405@2|Bacteria,1MUV6@1224|Proteobacteria,2TR49@28211|Alphaproteobacteria 28211|Alphaproteobacteria E gamma-glutamyltransferase ggt - 2.3.2.2,3.4.19.13 ko:K00681 ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100 - R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935 RC00064,RC00090,RC00096 ko00000,ko00001,ko01000,ko01002 - - - G_glu_transpept k59_771632_2 379066.GAU_2215 5.35e-54 184.0 COG0531@1|root,COG0531@2|Bacteria,1ZSST@142182|Gemmatimonadetes 142182|Gemmatimonadetes E Amino acid permease - - - ko:K03294 - - - - ko00000 2.A.3.2 - - AA_permease_2 k59_1511821_1 78398.KS43_02530 4.78e-21 89.4 COG2877@1|root,COG2877@2|Bacteria,1MV91@1224|Proteobacteria,1RMGQ@1236|Gammaproteobacteria,1MQ8H@122277|Pectobacterium 1236|Gammaproteobacteria F 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase kdsA GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0005996,GO:0006082,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0008676,GO:0009058,GO:0009059,GO:0009103,GO:0009987,GO:0016043,GO:0016051,GO:0016053,GO:0016740,GO:0016765,GO:0019294,GO:0019752,GO:0022607,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046364,GO:0046394,GO:0046400,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0065003,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901576,GO:1903509 2.5.1.55 ko:K01627 ko00540,ko01100,map00540,map01100 M00063 R03254 RC00435 ko00000,ko00001,ko00002,ko01000,ko01005 - - - DAHP_synth_1 k59_1734859_1 243159.AFE_2766 1.04e-48 166.0 COG0462@1|root,COG0462@2|Bacteria,1MW21@1224|Proteobacteria,1RMUC@1236|Gammaproteobacteria,2NBR5@225057|Acidithiobacillales 225057|Acidithiobacillales F Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) prs - 2.7.6.1 ko:K00948 ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230 M00005 R01049 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - Pribosyl_synth,Pribosyltran_N k59_1734859_2 1144275.COCOR_02413 1.05e-08 57.8 COG1825@1|root,COG1825@2|Bacteria,1RDH0@1224|Proteobacteria,42RVM@68525|delta/epsilon subdivisions,2WQIY@28221|Deltaproteobacteria,2YVJV@29|Myxococcales 28221|Deltaproteobacteria J This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance ctc GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02897 ko03010,map03010 M00178 - - ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L25p,Ribosomal_TL5_C k59_1786934_1 1192034.CAP_4434 7.02e-116 362.0 COG1529@1|root,COG1529@2|Bacteria,1QTTJ@1224|Proteobacteria,42NU9@68525|delta/epsilon subdivisions,2WKXG@28221|Deltaproteobacteria,2YWEG@29|Myxococcales 28221|Deltaproteobacteria C Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain - - - - - - - - - - - - Ald_Xan_dh_C2 k59_1676889_1 316407.85676634 3.14e-123 372.0 COG2183@1|root,COG2183@2|Bacteria,1MUA7@1224|Proteobacteria,1RMNH@1236|Gammaproteobacteria,3XMBH@561|Escherichia 1236|Gammaproteobacteria K response to ionizing radiation yhgF GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0009314,GO:0009628,GO:0010212,GO:0044424,GO:0044444,GO:0044464,GO:0050896 - ko:K06959 - - - - ko00000 - - - HHH_3,S1,Tex_N,Tex_YqgF k59_1511828_1 377629.TERTU_0041 2.24e-51 168.0 COG0009@1|root,COG0009@2|Bacteria,1MVPM@1224|Proteobacteria,1S610@1236|Gammaproteobacteria,2PNPZ@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria J Telomere recombination tsaC GO:0000049,GO:0000166,GO:0002949,GO:0003674,GO:0003676,GO:0003723,GO:0003725,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006450,GO:0006725,GO:0006807,GO:0008033,GO:0008144,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034470,GO:0034641,GO:0034660,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0061710,GO:0065007,GO:0065008,GO:0070525,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901363 2.7.7.87 ko:K07566 - - R10463 RC00745 ko00000,ko01000,ko03009,ko03016 - - - Sua5_yciO_yrdC k59_830448_1 1221522.B723_17025 5.6e-67 213.0 COG3777@1|root,COG3777@2|Bacteria,1P96N@1224|Proteobacteria,1S0X8@1236|Gammaproteobacteria,1YP77@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria S N-terminal half of MaoC dehydratase - - 4.2.1.153,4.2.1.56 ko:K09709,ko:K18291 ko00660,ko00720,ko01120,ko01200,map00660,map00720,map01120,map01200 M00376 R02491,R09282 RC00730,RC02479 ko00000,ko00001,ko00002,ko01000 - - - MaoC_dehydrat_N k59_1450375_1 525246.HMPREF0058_1347 2.08e-86 269.0 COG1653@1|root,COG1653@2|Bacteria,2ICAE@201174|Actinobacteria,4D6EJ@85005|Actinomycetales 201174|Actinobacteria G Bacterial extracellular solute-binding protein - - - ko:K10117 ko02010,map02010 M00196 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.28 - - SBP_bac_1,SBP_bac_8 k59_1786942_1 1122137.AQXF01000001_gene3044 1.61e-50 167.0 COG1451@1|root,COG1451@2|Bacteria,1MXZU@1224|Proteobacteria,2U1JG@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Metal-dependent hydrolase MA20_23375 - - ko:K07043 - - - - ko00000 - - - DUF45 k59_1786942_2 1118235.CAJH01000014_gene898 6.05e-17 78.6 COG2346@1|root,COG2346@2|Bacteria,1MZSM@1224|Proteobacteria,1SIRV@1236|Gammaproteobacteria,1X7KZ@135614|Xanthomonadales 135614|Xanthomonadales S Preprotein translocase subunit TatC - - - ko:K06886 - - - - ko00000 - - - Bac_globin k59_890705_1 1229203.KI301992_gene2376 0.000169 49.7 COG1361@1|root,COG4719@1|root,COG1361@2|Bacteria,COG4719@2|Bacteria,2HEWW@201174|Actinobacteria,3UX8F@52018|unclassified Actinobacteria (class) 201174|Actinobacteria M Parallel beta-helix repeats - - - - - - - - - - - - - k59_489362_1 744980.TRICHSKD4_5336 5.8e-39 140.0 COG0190@1|root,COG0190@2|Bacteria,1MWU4@1224|Proteobacteria,2TRZZ@28211|Alphaproteobacteria 28211|Alphaproteobacteria F Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate folD GO:0003674,GO:0003824,GO:0004477,GO:0004488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006730,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016645,GO:0016646,GO:0016787,GO:0016810,GO:0016814,GO:0019238,GO:0044237,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0055114 1.5.1.5,3.5.4.9 ko:K01491 ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200 M00140,M00377 R01220,R01655 RC00202,RC00578 ko00000,ko00001,ko00002,ko01000 - - - THF_DHG_CYH,THF_DHG_CYH_C k59_489362_2 1238190.AMQY01000013_gene1117 9.69e-08 52.8 COG0500@1|root,COG0500@2|Bacteria,1RAE4@1224|Proteobacteria,1S0RC@1236|Gammaproteobacteria,1XKMG@135619|Oceanospirillales 135619|Oceanospirillales Q Belongs to the class I-like SAM-binding methyltransferase superfamily. TPMT family tpm - 2.1.1.67 ko:K00569 ko00983,map00983 - R08236,R08239,R08246 RC00003,RC00980,RC02277 ko00000,ko00001,ko01000 - - - TPMT k59_1170772_1 195250.CM001776_gene2822 1.87e-110 342.0 COG1060@1|root,COG1060@2|Bacteria,1G1HR@1117|Cyanobacteria,1H000@1129|Synechococcus 1117|Cyanobacteria H Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) cofH GO:0003674,GO:0003824,GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016740,GO:0016765,GO:0044237,GO:0044249,GO:0044689,GO:0051186,GO:0051188 2.5.1.77 ko:K11781 ko00680,ko01120,map00680,map01120 M00378 R09396 RC01381,RC03002,RC03007 ko00000,ko00001,ko00002,ko01000 - - - Radical_SAM k59_489372_1 584708.Apau_1083 2.59e-73 234.0 COG0037@1|root,COG0037@2|Bacteria 2|Bacteria D tRNA processing tilS - 6.3.4.19 ko:K04075 - - R09597 RC02633,RC02634 ko00000,ko01000,ko03016 - - - ATP_bind_3,TilS,TilS_C k59_1280244_1 1121344.JHZO01000004_gene1173 8.78e-14 72.4 COG3728@1|root,COG3728@2|Bacteria,1VAD9@1239|Firmicutes,24JSU@186801|Clostridia,3WQ8E@541000|Ruminococcaceae 186801|Clostridia L Terminase small subunit - - - ko:K07474 - - - - ko00000 - - - Terminase_2 k59_1399153_1 1500306.JQLA01000059_gene2145 2.57e-83 258.0 COG0517@1|root,COG0517@2|Bacteria,1MXI6@1224|Proteobacteria,2TS6X@28211|Alphaproteobacteria,4B8QI@82115|Rhizobiaceae 28211|Alphaproteobacteria S Putative transposase - - - - - - - - - - - - Y2_Tnp,Zn_Tnp_IS91 k59_98402_1 1328313.DS2_05705 3.75e-100 309.0 COG0591@1|root,COG0591@2|Bacteria,1PNHU@1224|Proteobacteria,1S0S6@1236|Gammaproteobacteria,46A7Z@72275|Alteromonadaceae 1236|Gammaproteobacteria E Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family - - - - - - - - - - - - SSF k59_720719_1 1250232.JQNJ01000001_gene3020 4.33e-11 60.1 COG3070@1|root,COG3070@2|Bacteria,4NTQF@976|Bacteroidetes,1II85@117743|Flavobacteriia 976|Bacteroidetes K TfoX N-terminal domain - - - - - - - - - - - - TfoX_N k59_830462_1 639282.DEFDS_0037 3.8e-87 270.0 COG2805@1|root,COG2805@2|Bacteria,2GEUC@200930|Deferribacteres 200930|Deferribacteres NU Type II/IV secretion system protein - - - ko:K02669 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE k59_1450390_1 519989.ECTPHS_01494 4.47e-80 247.0 COG0596@1|root,COG0596@2|Bacteria,1MWW8@1224|Proteobacteria,1RMKF@1236|Gammaproteobacteria,1WWD5@135613|Chromatiales 135613|Chromatiales E Belongs to the peptidase S33 family - - 3.4.11.5 ko:K01259 ko00330,map00330 - R00135 - ko00000,ko00001,ko01000,ko01002 - - - Abhydrolase_1 k59_1734878_1 512565.AMIS_76040 9.54e-40 147.0 COG0438@1|root,COG0438@2|Bacteria,2GJ57@201174|Actinobacteria,4D8PR@85008|Micromonosporales 201174|Actinobacteria M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway mshA GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006790,GO:0008150,GO:0008152,GO:0008194,GO:0008375,GO:0009058,GO:0009987,GO:0010125,GO:0010126,GO:0016137,GO:0016138,GO:0016740,GO:0016757,GO:0016758,GO:0044237,GO:0044249,GO:0044272,GO:0044424,GO:0044444,GO:0044464,GO:0051186,GO:0051188,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1901657,GO:1901659 2.4.1.250 ko:K15521 - - - - ko00000,ko01000 - - - Glyco_transf_4,Glycos_transf_1 k59_433693_1 1229909.NSED_03085 5.26e-55 182.0 COG0530@1|root,arCOG02881@2157|Archaea,41T1S@651137|Thaumarchaeota 651137|Thaumarchaeota P Sodium/calcium exchanger protein - - - ko:K07301 - - - - ko00000,ko02000 2.A.19.5 - - Na_Ca_ex k59_152660_1 472759.Nhal_3283 9.03e-118 350.0 COG1004@1|root,COG1004@2|Bacteria,1MW5U@1224|Proteobacteria,1RMVW@1236|Gammaproteobacteria,1WX6X@135613|Chromatiales 135613|Chromatiales C Belongs to the UDP-glucose GDP-mannose dehydrogenase family - - 1.1.1.22 ko:K00012 ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100 M00014,M00129,M00361,M00362 R00286 RC00291 ko00000,ko00001,ko00002,ko01000 - - - UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N k59_771699_1 1415754.JQMK01000002_gene3616 6.14e-52 185.0 COG1858@1|root,COG2133@1|root,COG3055@1|root,COG3291@1|root,COG3391@1|root,COG5183@1|root,COG5563@1|root,COG1858@2|Bacteria,COG2133@2|Bacteria,COG3055@2|Bacteria,COG3291@2|Bacteria,COG3391@2|Bacteria,COG5183@2|Bacteria,COG5563@2|Bacteria,1R9K3@1224|Proteobacteria,1S1R4@1236|Gammaproteobacteria,466T2@72275|Alteromonadaceae 1236|Gammaproteobacteria G Kelch motif - - - - - - - - - - - - Kelch_1,Kelch_4,Kelch_6 k59_890732_1 1211114.ALIP01000115_gene1475 1.42e-104 323.0 COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,1RMQ4@1236|Gammaproteobacteria,1X3W8@135614|Xanthomonadales 135614|Xanthomonadales IQ Activates fatty acids by binding to coenzyme A rpfB - 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding,AMP-binding_C k59_830482_1 379066.GAU_1340 3.79e-37 143.0 COG0745@1|root,COG0784@1|root,COG2202@1|root,COG4191@1|root,COG0745@2|Bacteria,COG0784@2|Bacteria,COG2202@2|Bacteria,COG4191@2|Bacteria,1ZUC5@142182|Gemmatimonadetes 142182|Gemmatimonadetes T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA,Response_reg k59_659872_1 85643.Tmz1t_2959 1.61e-139 423.0 COG0243@1|root,COG0243@2|Bacteria,1P01N@1224|Proteobacteria,2VMWP@28216|Betaproteobacteria,2KVYZ@206389|Rhodocyclales 206389|Rhodocyclales C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - 1.17.5.1,3.1.2.25 ko:K18361 ko00360,map00360 - R07222,R07294 RC00004,RC01844,RC01903 ko00000,ko00001,ko01000 - - - Molybdopterin,Molydop_binding k59_1226803_1 1408419.JHYG01000002_gene1058 2.07e-12 67.8 COG0454@1|root,COG0456@2|Bacteria,1PMA3@1224|Proteobacteria,2TUU2@28211|Alphaproteobacteria,2JRDH@204441|Rhodospirillales 204441|Rhodospirillales K acetyltransferase - - - - - - - - - - - - - k59_1787987_1 382464.ABSI01000002_gene4380 1.38e-57 198.0 COG0154@1|root,COG0154@2|Bacteria,46TME@74201|Verrucomicrobia,2ITNX@203494|Verrucomicrobiae 203494|Verrucomicrobiae J Amidase - - - - - - - - - - - - Amidase k59_211101_2 436308.Nmar_0674 1.59e-09 57.8 COG0589@1|root,arCOG02053@2157|Archaea,41TB2@651137|Thaumarchaeota 651137|Thaumarchaeota T COG0589 Universal stress protein UspA and related nucleotide-binding proteins - - - - - - - - - - - - Usp k59_1400371_1 861299.J421_1107 8.75e-66 214.0 COG3391@1|root,COG3391@2|Bacteria,1ZSNC@142182|Gemmatimonadetes 142182|Gemmatimonadetes S amine dehydrogenase activity - - - - - - - - - - - - - k59_1281396_1 1356854.N007_00870 1.32e-26 111.0 COG2124@1|root,COG2124@2|Bacteria,1TPWZ@1239|Firmicutes,4HAGS@91061|Bacilli,279CK@186823|Alicyclobacillaceae 91061|Bacilli Q Belongs to the cytochrome P450 family - - - - - - - - - - - - p450 k59_1735775_1 32057.KB217483_gene10078 2.01e-20 95.1 COG3385@1|root,2ZA2Q@2|Bacteria,1G4UP@1117|Cyanobacteria,1HTE9@1161|Nostocales 1117|Cyanobacteria L transposase activity - - - - - - - - - - - - DDE_Tnp_1 k59_268730_1 78245.Xaut_3373 2.17e-114 337.0 COG0451@1|root,COG0451@2|Bacteria,1MWVE@1224|Proteobacteria,2TS8F@28211|Alphaproteobacteria,3F1HG@335928|Xanthobacteraceae 28211|Alphaproteobacteria GM PFAM NAD-dependent epimerase dehydratase - GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0016491,GO:0016614,GO:0016616,GO:0050388,GO:0055114 1.1.1.203 ko:K18981 ko00053,map00053 - R10841 RC00066 ko00000,ko00001,ko01000 - - - Epimerase k59_1171606_1 749222.Nitsa_0633 4.23e-17 80.9 COG0809@1|root,COG0809@2|Bacteria,1MUH3@1224|Proteobacteria,42MMG@68525|delta/epsilon subdivisions,2YMCT@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) queA - 2.4.99.17 ko:K07568 - - - - ko00000,ko01000,ko03016 - - - Queuosine_synth k59_43433_1 436308.Nmar_0048 1.09e-88 273.0 COG0301@1|root,arCOG00038@2157|Archaea,41ST5@651137|Thaumarchaeota 651137|Thaumarchaeota H Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS - - - - - - - - - - - - - k59_490380_1 1167006.UWK_00349 1.85e-60 200.0 COG0535@1|root,COG1433@1|root,COG0535@2|Bacteria,COG1433@2|Bacteria,1MWDC@1224|Proteobacteria,42MHB@68525|delta/epsilon subdivisions,2WIPH@28221|Deltaproteobacteria,2MHW8@213118|Desulfobacterales 28221|Deltaproteobacteria C cofactor biosynthesis protein NifB nifB - - ko:K02585 - - - - ko00000 - - - Fer4_14,Nitro_FeMo-Co,Radical_SAM k59_1400385_1 1122137.AQXF01000005_gene1306 8.24e-123 379.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2TQT0@28211|Alphaproteobacteria 28211|Alphaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_1451346_1 1168065.DOK_16913 3.81e-21 97.1 COG2982@1|root,COG2982@2|Bacteria,1P6EN@1224|Proteobacteria,1S1EC@1236|Gammaproteobacteria,1J9AE@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Protein involved in outer membrane biogenesis - - - - - - - - - - - - DUF748 k59_942663_1 1347342.BN863_35680 3.45e-74 244.0 COG4772@1|root,COG4772@2|Bacteria,4PKRQ@976|Bacteroidetes,1HX89@117743|Flavobacteriia 976|Bacteroidetes P TonB-dependent receptor - - - - - - - - - - - - CarbopepD_reg_2,CarboxypepD_reg,OMP_b-brl_3 k59_211125_1 223926.28805310 2.02e-47 164.0 COG0142@1|root,COG0142@2|Bacteria,1MUK6@1224|Proteobacteria,1RPR7@1236|Gammaproteobacteria,1XTYZ@135623|Vibrionales 135623|Vibrionales H Belongs to the FPP GGPP synthase family ispB - 2.5.1.90 ko:K02523 ko00900,ko01110,map00900,map01110 - R09248 RC00279 ko00000,ko00001,ko01000,ko01006 - - - polyprenyl_synt k59_998758_1 572477.Alvin_2167 2.14e-84 267.0 COG0737@1|root,COG0737@2|Bacteria,1MX03@1224|Proteobacteria,1RPX3@1236|Gammaproteobacteria,1WXJT@135613|Chromatiales 135613|Chromatiales F Belongs to the 5'-nucleotidase family - - - ko:K17224 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00595 R10151 RC03151,RC03152 ko00000,ko00001,ko00002 - - - 5_nucleotid_C k59_490399_1 436308.Nmar_1272 2.64e-57 181.0 COG0589@1|root,arCOG02053@2157|Archaea 2157|Archaea T COG0589 Universal stress protein UspA and related nucleotide-binding proteins - - - - - - - - - - - - Usp k59_1513004_1 436308.Nmar_0846 3.19e-89 273.0 COG0026@1|root,arCOG01597@2157|Archaea,41SD9@651137|Thaumarchaeota 651137|Thaumarchaeota F Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) purK - 6.3.4.18 ko:K01589 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R07404 RC01927 ko00000,ko00001,ko00002,ko01000 - - - ATP-grasp k59_326904_1 1298867.AUES01000067_gene5125 9.57e-32 127.0 COG2203@1|root,COG4191@1|root,COG2203@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TTJ0@28211|Alphaproteobacteria,3JS5D@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria T Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - - - - - - - - - - GAF_2,HAMP,HATPase_c,HisKA,PAS_7,dCache_1 k59_153848_1 948106.AWZT01000007_gene3549 6.74e-101 318.0 COG2183@1|root,COG2183@2|Bacteria,1MUA7@1224|Proteobacteria,2VH6A@28216|Betaproteobacteria,1K0R2@119060|Burkholderiaceae 28216|Betaproteobacteria K SMART Resolvase, RNase H domain protein fold tex - - ko:K06959 - - - - ko00000 - - - HHH_3,S1,Tex_N,Tex_YqgF k59_831425_1 391626.OAN307_c35030 2.27e-38 147.0 COG2931@1|root,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,2TRVY@28211|Alphaproteobacteria 28211|Alphaproteobacteria Q COG2931 RTX toxins and related Ca2 -binding proteins - - - - - - - - - - - - HemolysinCabind k59_43450_1 511145.b0643 3.65e-55 175.0 COG2888@1|root,COG2888@2|Bacteria,1P9T7@1224|Proteobacteria,1RYIB@1236|Gammaproteobacteria,3XMF4@561|Escherichia 1236|Gammaproteobacteria J Zinc-ribbon containing domain ybeL - - - - - - - - - - - DUF1451 k59_211128_1 1449076.JOOE01000002_gene726 1.23e-207 587.0 COG3670@1|root,COG3670@2|Bacteria,1MY1X@1224|Proteobacteria,2TS7A@28211|Alphaproteobacteria,2K2PY@204457|Sphingomonadales 204457|Sphingomonadales Q Retinal pigment epithelial membrane protein - - - ko:K11159 - - - - ko00000 - - - RPE65 k59_608460_1 702113.PP1Y_AT198 5.38e-50 162.0 COG1329@1|root,COG1329@2|Bacteria,1MWI2@1224|Proteobacteria,2TTVP@28211|Alphaproteobacteria,2K0TA@204457|Sphingomonadales 204457|Sphingomonadales K CarD family transcriptional regulator - - - ko:K07736 - - - - ko00000,ko03000 - - - CarD_CdnL_TRCF k59_1227679_1 1469613.JT55_08595 6.49e-36 138.0 COG2374@1|root,COG2374@2|Bacteria 2|Bacteria - - xynX1 - 3.1.3.8 ko:K01083 ko00562,map00562 - R03371 RC00078 ko00000,ko00001,ko01000 - - - Big_5,CBM_3,DUF5011,Exo_endo_phos,F5_F8_type_C,LTD,SLH k59_1281415_2 1121020.JIAG01000003_gene2590 3.65e-31 117.0 COG0558@1|root,COG0558@2|Bacteria,2GM3F@201174|Actinobacteria,1W98W@1268|Micrococcaceae 201174|Actinobacteria I Belongs to the CDP-alcohol phosphatidyltransferase class-I family - - 2.7.8.41 ko:K08744 ko00564,ko01100,map00564,map01100 - R02030 RC00002,RC00017 ko00000,ko00001,ko01000 - - - CDP-OH_P_transf k59_721889_1 983544.Lacal_2608 4.89e-47 167.0 COG0542@1|root,COG0542@2|Bacteria,4NE1J@976|Bacteroidetes,1HWVR@117743|Flavobacteriia 976|Bacteroidetes O Belongs to the ClpA ClpB family clpC - - ko:K03696 ko01100,map01100 - - - ko00000,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N,UVR k59_1400422_1 2074.JNYD01000045_gene7435 5.33e-33 127.0 COG1804@1|root,COG1804@2|Bacteria,2GIU7@201174|Actinobacteria,4DZ1Z@85010|Pseudonocardiales 201174|Actinobacteria C PFAM CoA-transferase family III - - 2.8.3.16 ko:K07749 - - - - ko00000,ko01000 - - - CoA_transf_3 k59_1400422_2 296591.Bpro_3015 7.6e-28 110.0 COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,2VHMS@28216|Betaproteobacteria,4ABPG@80864|Comamonadaceae 28216|Betaproteobacteria I Belongs to the thiolase family - - 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N k59_1171650_1 1122137.AQXF01000001_gene3256 4.71e-107 320.0 COG0484@1|root,COG0484@2|Bacteria,1MVMS@1224|Proteobacteria,2TRZ1@28211|Alphaproteobacteria 28211|Alphaproteobacteria O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins dnaJ - - ko:K03686 - - - - ko00000,ko03029,ko03110 - - - DnaJ,DnaJ_C,DnaJ_CXXCXGXG k59_326919_1 1123279.ATUS01000002_gene15 9.31e-21 90.9 COG1064@1|root,COG1064@2|Bacteria,1MUTT@1224|Proteobacteria,1RPQC@1236|Gammaproteobacteria,1J8BK@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Alcohol dehydrogenase GroES-like domain adhA - 1.1.1.1 ko:K13953 ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220 - R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310 RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273 ko00000,ko00001,ko01000 - - - ADH_N k59_326919_2 509191.AEDB02000064_gene524 0.000171 46.2 COG2972@1|root,COG2972@2|Bacteria,1TPVR@1239|Firmicutes,247XB@186801|Clostridia,3WP5W@541000|Ruminococcaceae 186801|Clostridia T Histidine kinase - - - - - - - - - - - - 7TMR-DISM_7TM,HATPase_c,His_kinase k59_1281427_1 95619.PM1_0229045 7.34e-73 228.0 COG1475@1|root,COG1475@2|Bacteria,1MW2E@1224|Proteobacteria,1RN65@1236|Gammaproteobacteria 1236|Gammaproteobacteria K Belongs to the ParB family parB - - ko:K03497 - - - - ko00000,ko03000,ko03036,ko04812 - - - ParBc k59_608473_1 314287.GB2207_06778 2.25e-89 267.0 COG0193@1|root,COG0193@2|Bacteria,1MX1P@1224|Proteobacteria,1RPK3@1236|Gammaproteobacteria,1J5S9@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis pth GO:0003674,GO:0003824,GO:0004045,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006508,GO:0006515,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016787,GO:0016788,GO:0019538,GO:0030163,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044464,GO:0051603,GO:0052689,GO:0071704,GO:0140098,GO:0140101,GO:1901564,GO:1901565,GO:1901575 3.1.1.29 ko:K01056 - - - - ko00000,ko01000,ko03012 - - - Pept_tRNA_hydro k59_490439_1 1178482.BJB45_02235 2.93e-29 114.0 COG0157@1|root,COG0157@2|Bacteria,1MW0C@1224|Proteobacteria,1RMBU@1236|Gammaproteobacteria,1XHMZ@135619|Oceanospirillales 135619|Oceanospirillales H Belongs to the NadC ModD family nadC - 2.4.2.19 ko:K00767 ko00760,ko01100,map00760,map01100 M00115 R03348 RC02877 ko00000,ko00001,ko00002,ko01000 - - - QRPTase_C,QRPTase_N k59_490439_2 1159870.KB907784_gene3113 5.86e-13 68.9 COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,2VI09@28216|Betaproteobacteria,3T1ES@506|Alcaligenaceae 28216|Betaproteobacteria C FAD linked oxidases, C-terminal domain - - - - - - - - - - - - FAD-oxidase_C,FAD_binding_4 k59_1281433_1 247633.GP2143_04980 3.46e-50 171.0 COG0672@1|root,COG0672@2|Bacteria,1N48M@1224|Proteobacteria,1S7GF@1236|Gammaproteobacteria,1J6PW@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P COG0672 High-affinity Fe2 Pb2 permease - - - ko:K07243 - - - - ko00000,ko02000 2.A.108.1,2.A.108.2 - - FTR1 k59_392546_1 1121360.AUAQ01000011_gene330 2.06e-25 105.0 COG0111@1|root,COG0111@2|Bacteria,2GP09@201174|Actinobacteria,22JN3@1653|Corynebacteriaceae 201174|Actinobacteria EH Phosphoglycerate dehydrogenase and related dehydrogenases - - - - - - - - - - - - 2-Hacid_dh_C k59_951541_1 465817.ETA_05410 9.72e-23 101.0 COG5297@1|root,COG5297@2|Bacteria,1R6PF@1224|Proteobacteria,1RZMP@1236|Gammaproteobacteria,3X6AI@551|Erwinia 1236|Gammaproteobacteria G Pectate lyase hrpW - - - - - - - - - - - CBM_6,Pectate_lyase k59_1346778_1 1415778.JQMM01000001_gene871 2.79e-128 374.0 COG0849@1|root,COG0849@2|Bacteria,1MUSR@1224|Proteobacteria,1RMXY@1236|Gammaproteobacteria,1J4FB@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria D Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring ftsA GO:0000166,GO:0003674,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008144,GO:0008150,GO:0009898,GO:0009987,GO:0016020,GO:0017076,GO:0030554,GO:0032153,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0051301,GO:0071944,GO:0097159,GO:0097367,GO:0098552,GO:0098562,GO:1901265,GO:1901363 - ko:K03590 ko04112,map04112 - - - ko00000,ko00001,ko03036,ko04812 - - - FtsA,SHS2_FTSA k59_162550_1 1463926.JOCA01000001_gene4496 3.01e-116 357.0 COG1523@1|root,COG1523@2|Bacteria,2GJ00@201174|Actinobacteria 201174|Actinobacteria G Belongs to the glycosyl hydrolase 13 family glgX1 - 3.2.1.68 ko:K01214 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R09995,R11261 - ko00000,ko00001,ko00002,ko01000 - CBM48,GH13 - Alpha-amylase,CBM_48 k59_162550_2 1131553.JIBI01000050_gene1003 2.69e-256 723.0 COG0376@1|root,COG0376@2|Bacteria,1MUBF@1224|Proteobacteria,2VH5H@28216|Betaproteobacteria 28216|Betaproteobacteria P Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity katG2 - 1.11.1.21 ko:K03782 ko00360,ko00380,ko00940,ko00983,ko01100,ko01110,map00360,map00380,map00940,map00983,map01100,map01110 - R00602,R00698,R02596,R02670,R03919,R04007,R07443,R11906 RC00034,RC00213,RC00767,RC02141 ko00000,ko00001,ko01000 - - - peroxidase k59_900703_1 198214.SF2868 2.73e-67 222.0 COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,1RN40@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Xanthine dehydrogenase xdhA GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0016491,GO:0055114 1.17.1.4 ko:K00087 ko00230,ko01100,ko01120,map00230,map01100,map01120 M00546 R01768,R02103 RC00143 ko00000,ko00001,ko00002,ko01000 - - iEcHS_1320.EcHS_A3026 Ald_Xan_dh_C,Ald_Xan_dh_C2 k59_900708_1 1205680.CAKO01000029_gene5271 1.02e-16 84.7 COG3653@1|root,COG3653@2|Bacteria,1MWWY@1224|Proteobacteria,2U2SV@28211|Alphaproteobacteria,2JZPJ@204441|Rhodospirillales 28211|Alphaproteobacteria Q Amidohydrolase family - - - - - - - - - - - - Amidohydro_3 k59_1687295_1 396588.Tgr7_0270 8.78e-83 258.0 COG1282@1|root,COG1282@2|Bacteria,1MUP4@1224|Proteobacteria,1RMR4@1236|Gammaproteobacteria 1236|Gammaproteobacteria C The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane pntB - 1.6.1.2 ko:K00325 ko00760,ko01100,map00760,map01100 - R00112 RC00001 ko00000,ko00001,ko01000 - - - PNTB k59_335386_1 498211.CJA_3217 1.92e-72 240.0 COG0060@1|root,COG0060@2|Bacteria,1MVBQ@1224|Proteobacteria,1RMTF@1236|Gammaproteobacteria,1FGXJ@10|Cellvibrio 1236|Gammaproteobacteria J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) ileS GO:0003674,GO:0003824,GO:0004812,GO:0004822,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006428,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.5 ko:K01870 ko00970,map00970 M00359,M00360 R03656 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iG2583_1286.G2583_0027,iPC815.YPO0475 Anticodon_1,tRNA-synt_1,zf-FPG_IleRS k59_335386_2 1137799.GZ78_24265 0.000253 43.5 COG0196@1|root,COG0196@2|Bacteria,1MV9I@1224|Proteobacteria,1RN44@1236|Gammaproteobacteria,1XHBV@135619|Oceanospirillales 135619|Oceanospirillales H Belongs to the ribF family ribF - 2.7.1.26,2.7.7.2 ko:K11753 ko00740,ko01100,ko01110,map00740,map01100,map01110 M00125 R00161,R00549 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - FAD_syn,Flavokinase k59_1579288_1 1484158.PSNIH1_06980 2.85e-67 223.0 COG0405@1|root,COG0405@2|Bacteria,1MUV6@1224|Proteobacteria,1RMIT@1236|Gammaproteobacteria,3VY83@53335|Pantoea 1236|Gammaproteobacteria M cleaves the gammaglutamyl linkages of compounds such as glutathione and transfer the gammaglutamyl group to other amino acids and peptides ggt GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0006082,GO:0006508,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0008242,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016787,GO:0019538,GO:0019752,GO:0030288,GO:0030313,GO:0031975,GO:0034722,GO:0036374,GO:0042597,GO:0043094,GO:0043102,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0070011,GO:0071704,GO:0097264,GO:0140096,GO:1901564,GO:1901566,GO:1901576 2.3.2.2,3.4.19.13 ko:K00681 ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100 - R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935 RC00064,RC00090,RC00096 ko00000,ko00001,ko01000,ko01002 - - iAPECO1_1312.APECO1_3012,iECOK1_1307.ECOK1_3869,iECS88_1305.ECS88_3844,iECW_1372.ECW_m3706,iEKO11_1354.EKO11_0296,iETEC_1333.ETEC_3693,iUMN146_1321.UM146_17325,iUTI89_1310.UTI89_C3954,iWFL_1372.ECW_m3706 G_glu_transpept k59_277755_1 102232.GLO73106DRAFT_00015860 2.54e-53 183.0 COG0405@1|root,COG0405@2|Bacteria,1G20A@1117|Cyanobacteria 1117|Cyanobacteria E PFAM Gamma-glutamyltranspeptidase - - 2.3.2.2,3.4.19.13 ko:K00681 ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100 - R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935 RC00064,RC00090,RC00096 ko00000,ko00001,ko01000,ko01002 - - - G_glu_transpept k59_1687302_1 644282.Deba_0636 2.18e-40 145.0 COG0547@1|root,COG0547@2|Bacteria,1MUPV@1224|Proteobacteria,42NRG@68525|delta/epsilon subdivisions,2WJRU@28221|Deltaproteobacteria 28221|Deltaproteobacteria F Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) trpD GO:0000162,GO:0003674,GO:0003824,GO:0004048,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.18,4.1.3.27 ko:K00766,ko:K13497 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R00985,R00986,R01073 RC00010,RC00440,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_2495 GATase,Glycos_trans_3N,Glycos_transf_3 k59_1687302_2 290397.Adeh_2656 1.96e-68 218.0 COG1136@1|root,COG1136@2|Bacteria,1MU45@1224|Proteobacteria,42P6Q@68525|delta/epsilon subdivisions,2WKPS@28221|Deltaproteobacteria,2YXDB@29|Myxococcales 28221|Deltaproteobacteria P ABC transporter - - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_1687302_3 1299327.I546_6005 1.9e-17 84.3 COG0577@1|root,COG0577@2|Bacteria,2I5G9@201174|Actinobacteria,23906@1762|Mycobacteriaceae 201174|Actinobacteria V ABC-type transport system, involved in lipoprotein release, permease component - - - - - - - - - - - - FtsX k59_1409464_1 1499967.BAYZ01000001_gene5910 4.24e-82 269.0 COG0525@1|root,COG0525@2|Bacteria,2NNKR@2323|unclassified Bacteria 2|Bacteria J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner valS GO:0000287,GO:0002161,GO:0003674,GO:0003824,GO:0004812,GO:0004832,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006417,GO:0006418,GO:0006438,GO:0006450,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0016070,GO:0016787,GO:0016788,GO:0016874,GO:0016875,GO:0019222,GO:0019538,GO:0019752,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0034248,GO:0034250,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045727,GO:0045903,GO:0046483,GO:0046872,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0052689,GO:0060255,GO:0061475,GO:0065007,GO:0065008,GO:0071704,GO:0080090,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:2000112 6.1.1.9 ko:K01873 ko00970,map00970 M00359,M00360 R03665 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iECH74115_1262.ECH74115_5779,iECNA114_1301.ECNA114_4481,iECO26_1355.ECO26_5428,iECSP_1301.ECSP_5359,iECs_1301.ECs5235,iG2583_1286.G2583_5088,iJN746.PP_0977,iSBO_1134.SBO_4182,iSSON_1240.SSON_4443,iYL1228.KPN_04663,iZ_1308.Z5870 Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1 k59_1409464_2 1268622.AVS7_01181 7.42e-52 180.0 COG1262@1|root,COG1262@2|Bacteria,1MUNC@1224|Proteobacteria,2VH4V@28216|Betaproteobacteria,4AB40@80864|Comamonadaceae 28216|Betaproteobacteria S DinB superfamily egtB - - - - - - - - - - - DinB_2,FGE-sulfatase k59_1290651_1 1317118.ATO8_06091 1.15e-73 236.0 COG0404@1|root,COG0404@2|Bacteria,1MV96@1224|Proteobacteria,2TRN4@28211|Alphaproteobacteria,4KK2T@93682|Roseivivax 28211|Alphaproteobacteria E Glycine cleavage T-protein C-terminal barrel domain gcvT GO:0001505,GO:0003674,GO:0003824,GO:0004047,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005960,GO:0006082,GO:0006520,GO:0006544,GO:0006546,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008483,GO:0009056,GO:0009063,GO:0009069,GO:0009071,GO:0009987,GO:0016054,GO:0016740,GO:0016741,GO:0016769,GO:0017144,GO:0019464,GO:0019752,GO:0032259,GO:0032991,GO:0042133,GO:0042135,GO:0042737,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0065007,GO:0065008,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606,GO:1902494,GO:1990204 2.1.2.10 ko:K00605 ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200 M00532 R01221,R02300,R04125 RC00022,RC00069,RC00183,RC02834 ko00000,ko00001,ko00002,ko01000 - - - GCV_T,GCV_T_C k59_1121258_1 1122137.AQXF01000007_gene3573 2.36e-178 513.0 COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,1NBSJ@1224|Proteobacteria,2TU21@28211|Alphaproteobacteria 28211|Alphaproteobacteria C COG1014 Pyruvate ferredoxin oxidoreductase and related 2-oxoacid ferredoxin oxidoreductases, gamma subunit MA20_01045 - 1.2.7.11,1.2.7.3 ko:K00174 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - PFOR_II,POR,POR_N k59_1121258_2 1122137.AQXF01000007_gene3572 3.81e-117 342.0 COG1013@1|root,COG1013@2|Bacteria,1R5BF@1224|Proteobacteria,2TR4R@28211|Alphaproteobacteria 28211|Alphaproteobacteria C COG1013 Pyruvate ferredoxin oxidoreductase and related 2-oxoacid ferredoxin oxidoreductases, beta subunit MA20_01040 - 1.2.7.11,1.2.7.3 ko:K00175 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - PFO_beta_C,TPP_enzyme_C k59_617593_1 266809.PM03_05055 2.79e-28 107.0 COG3193@1|root,COG3193@2|Bacteria,1N08N@1224|Proteobacteria,2U5ES@28211|Alphaproteobacteria 28211|Alphaproteobacteria S protein possibly involved in utilization of glycolate and propanediol - - - - - - - - - - - - Haem_degrading k59_554458_1 1122137.AQXF01000002_gene588 4.5e-60 206.0 COG2366@1|root,COG2366@2|Bacteria,1MVMH@1224|Proteobacteria,2TS4D@28211|Alphaproteobacteria 28211|Alphaproteobacteria E COG2366 Protein related to penicillin acylase quiP - 3.5.1.11 ko:K01434 ko00311,ko01130,map00311,map01130 - R02170 RC00166,RC00328 ko00000,ko00001,ko01000,ko01002 - - - Penicil_amidase k59_617596_1 42345.XP_008783388.1 4.82e-13 75.1 COG0626@1|root,KOG0053@2759|Eukaryota,37HJ8@33090|Viridiplantae,3GEKB@35493|Streptophyta,3KQSB@4447|Liliopsida 35493|Streptophyta E cystathionine beta-lyase CBL GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0003962,GO:0004121,GO:0004123,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006534,GO:0006555,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009070,GO:0009086,GO:0009092,GO:0009507,GO:0009532,GO:0009536,GO:0009570,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0016829,GO:0016846,GO:0017144,GO:0019279,GO:0019343,GO:0019344,GO:0019346,GO:0019752,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0046394,GO:0048037,GO:0050662,GO:0050667,GO:0070279,GO:0071265,GO:0071266,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.4.1.8 ko:K01760 ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230 M00017 R00782,R01286,R02408,R04941 RC00056,RC00069,RC00382,RC00488,RC00710,RC01245,RC02303 ko00000,ko00001,ko00002,ko01000 - - - Cys_Met_Meta_PP k59_951575_1 391615.ABSJ01000056_gene1539 3.49e-30 120.0 COG3107@1|root,COG3107@2|Bacteria,1MUHR@1224|Proteobacteria,1RXX4@1236|Gammaproteobacteria,1J4Z4@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M lipoprotein lpoA GO:0000270,GO:0003674,GO:0005575,GO:0005623,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009279,GO:0009987,GO:0016020,GO:0019867,GO:0030203,GO:0030234,GO:0030312,GO:0030313,GO:0031241,GO:0031975,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044425,GO:0044462,GO:0044464,GO:0050790,GO:0065007,GO:0065009,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:0098552,GO:0098772,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 - ko:K07121 - - - - ko00000 - - - LppC k59_392571_1 436229.JOEH01000043_gene568 1.19e-88 281.0 COG1574@1|root,COG1574@2|Bacteria,2GJVW@201174|Actinobacteria,2NHRC@228398|Streptacidiphilus 201174|Actinobacteria S Amidohydrolase family - - - - - - - - - - - - Amidohydro_3 k59_277793_1 1030157.AFMP01000052_gene157 1.01e-25 105.0 COG1894@1|root,COG1894@2|Bacteria,1MV8F@1224|Proteobacteria,2TRAH@28211|Alphaproteobacteria,2JZYB@204457|Sphingomonadales 204457|Sphingomonadales C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain nuoF - 1.6.5.3 ko:K00335 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_51K,NADH_4Fe-4S,SLBB k59_277793_2 519989.ECTPHS_07067 2.38e-127 385.0 COG1034@1|root,COG1034@2|Bacteria,1P8MN@1224|Proteobacteria,1RMUH@1236|Gammaproteobacteria,1WWAH@135613|Chromatiales 135613|Chromatiales C TIGRFAM NADH-quinone oxidoreductase, chain G - - 1.6.5.3 ko:K00336 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Fer2_4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3 k59_669699_1 1128421.JAGA01000003_gene3588 1.89e-167 478.0 COG4213@1|root,COG4213@2|Bacteria,2NQJ2@2323|unclassified Bacteria 2|Bacteria G Periplasmic binding protein domain - - - ko:K10546 ko02010,map02010 M00216 - - ko00000,ko00001,ko00002,ko02000 3.A.1.2.5 - - Peripla_BP_4 k59_1180953_1 1088721.NSU_1958 1.19e-59 192.0 COG0584@1|root,COG0584@2|Bacteria,1MU8H@1224|Proteobacteria,2TV1D@28211|Alphaproteobacteria,2K3TX@204457|Sphingomonadales 204457|Sphingomonadales C glycerophosphoryl diester phosphodiesterase - - - - - - - - - - - - GDPD k59_1180953_2 1096930.L284_01920 1.1e-13 70.1 COG3146@1|root,COG3146@2|Bacteria,1MU35@1224|Proteobacteria,2TS5I@28211|Alphaproteobacteria,2K1NQ@204457|Sphingomonadales 204457|Sphingomonadales S protein conserved in bacteria - - - ko:K09919 - - - - ko00000 - - - FemAB_like k59_952446_1 90813.JQMT01000001_gene1190 2.24e-33 124.0 COG2908@1|root,COG2908@2|Bacteria,1MVKD@1224|Proteobacteria,1RQIA@1236|Gammaproteobacteria,4605X@72273|Thiotrichales 72273|Thiotrichales S Calcineurin-like phosphoesterase superfamily domain - - - - - - - - - - - - Metallophos_2 k59_952446_2 394221.Mmar10_0397 5.87e-50 171.0 COG0438@1|root,COG0438@2|Bacteria,1MUB7@1224|Proteobacteria,2TQQ0@28211|Alphaproteobacteria,43W4A@69657|Hyphomonadaceae 28211|Alphaproteobacteria M COG0438 Glycosyltransferase - - - - - - - - - - - - Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1 k59_1007917_1 1229909.NSED_06385 2.24e-106 317.0 COG0372@1|root,arCOG04237@2157|Archaea,41SAN@651137|Thaumarchaeota 651137|Thaumarchaeota C TIGRFAM 2-methylcitrate synthase citrate synthase II - - 2.3.3.1 ko:K01647 ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00740 R00351 RC00004,RC00067 br01601,ko00000,ko00001,ko00002,ko01000 - - - Citrate_synt k59_1632917_1 765913.ThidrDRAFT_3766 3.47e-88 269.0 COG0190@1|root,COG0190@2|Bacteria,1MWU4@1224|Proteobacteria,1RNSW@1236|Gammaproteobacteria,1WWX4@135613|Chromatiales 135613|Chromatiales F Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate folD - 1.5.1.5,3.5.4.9 ko:K01491 ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200 M00140,M00377 R01220,R01655 RC00202,RC00578 ko00000,ko00001,ko00002,ko01000 - - - THF_DHG_CYH,THF_DHG_CYH_C k59_1632917_2 631454.N177_1089 1.87e-26 107.0 COG0404@1|root,COG0404@2|Bacteria,1MV96@1224|Proteobacteria,2TRN4@28211|Alphaproteobacteria,1JNE3@119043|Rhodobiaceae 28211|Alphaproteobacteria E Glycine cleavage T-protein C-terminal barrel domain gcvT GO:0001505,GO:0003674,GO:0003824,GO:0004047,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005960,GO:0006082,GO:0006520,GO:0006544,GO:0006546,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008483,GO:0009056,GO:0009063,GO:0009069,GO:0009071,GO:0009987,GO:0016054,GO:0016740,GO:0016741,GO:0016769,GO:0017144,GO:0019464,GO:0019752,GO:0032259,GO:0032991,GO:0042133,GO:0042135,GO:0042737,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0065007,GO:0065008,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606,GO:1902494,GO:1990204 2.1.2.10 ko:K00605 ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200 M00532 R01221,R02300,R04125 RC00022,RC00069,RC00183,RC02834 ko00000,ko00001,ko00002,ko01000 - - - GCV_T,GCV_T_C k59_109029_1 316407.1799817 2.92e-103 303.0 COG0005@1|root,COG0005@2|Bacteria,1MUWW@1224|Proteobacteria,1RS0S@1236|Gammaproteobacteria,3XPEV@561|Escherichia 1236|Gammaproteobacteria F The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate xapA GO:0003674,GO:0003824,GO:0004731,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006148,GO:0006149,GO:0006152,GO:0006161,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008477,GO:0008617,GO:0009056,GO:0009116,GO:0009119,GO:0009120,GO:0009164,GO:0009987,GO:0015949,GO:0016043,GO:0016740,GO:0016757,GO:0016763,GO:0016787,GO:0016798,GO:0016799,GO:0019439,GO:0022607,GO:0034214,GO:0034641,GO:0034655,GO:0034656,GO:0042278,GO:0042453,GO:0042454,GO:0042802,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0044424,GO:0044464,GO:0046094,GO:0046102,GO:0046115,GO:0046121,GO:0046122,GO:0046124,GO:0046128,GO:0046130,GO:0046483,GO:0046700,GO:0047724,GO:0047975,GO:0051259,GO:0055086,GO:0065003,GO:0071704,GO:0071840,GO:0072521,GO:0072523,GO:1901068,GO:1901069,GO:1901135,GO:1901136,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575,GO:1901657,GO:1901658,GO:1903227,GO:1903228 2.4.2.1,2.4.2.28,2.4.2.44 ko:K00772,ko:K03783,ko:K03815,ko:K19696 ko00230,ko00240,ko00270,ko00760,ko01100,ko01110,map00230,map00240,map00270,map00760,map01100,map01110 M00034 R01402,R01561,R01863,R01969,R02147,R02294,R02295,R02297,R02484,R02557,R02748,R08368,R09668,R10244 RC00033,RC00063,RC00122,RC02819 ko00000,ko00001,ko00002,ko01000 - - iPC815.YPO1171,iUMN146_1321.UM146_04590,iUTI89_1310.UTI89_C2739 PNP_UDP_1 k59_670511_1 745411.B3C1_16300 5.86e-32 127.0 COG1629@1|root,COG4771@2|Bacteria,1MU9K@1224|Proteobacteria,1RMTG@1236|Gammaproteobacteria,1J9RX@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P COG1629 Outer membrane receptor proteins, mostly Fe transport - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_1236685_1 1380600.AUYN01000003_gene141 8.28e-65 209.0 COG1058@1|root,COG1546@1|root,COG1058@2|Bacteria,COG1546@2|Bacteria,4NDVV@976|Bacteroidetes,1HWME@117743|Flavobacteriia 976|Bacteroidetes S Belongs to the CinA family cinA - 3.5.1.42 ko:K03742,ko:K03743 ko00760,map00760 - R02322 RC00100 ko00000,ko00001,ko01000 - - - CinA,MoCF_biosynth k59_1236685_2 504487.JCM19302_703 6.1e-49 158.0 COG2198@1|root,COG2198@2|Bacteria,4NVS6@976|Bacteroidetes,1I5MU@117743|Flavobacteriia 976|Bacteroidetes T (Hpt) domain - - - - - - - - - - - - Hpt k59_1236685_3 746697.Aeqsu_2088 1.44e-20 86.7 COG0179@1|root,COG0179@2|Bacteria,4NGCT@976|Bacteroidetes,1HX6X@117743|Flavobacteriia 976|Bacteroidetes Q 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase fahA - - - - - - - - - - - FAA_hydrolase k59_1580186_1 1030157.AFMP01000036_gene2567 2.31e-23 102.0 COG3119@1|root,COG3119@2|Bacteria,1MV92@1224|Proteobacteria,2TTXG@28211|Alphaproteobacteria,2K2F0@204457|Sphingomonadales 204457|Sphingomonadales P PFAM Sulfatase - - 3.1.6.1 ko:K01130 ko00140,ko00600,map00140,map00600 - R03980,R04856 RC00128,RC00231 ko00000,ko00001,ko01000 - - - Sulfatase k59_1580186_2 877415.JNJQ01000005_gene1285 1.7e-82 254.0 COG1028@1|root,COG1028@2|Bacteria,1TRYD@1239|Firmicutes,3VQ2H@526524|Erysipelotrichia 526524|Erysipelotrichia IQ Enoyl-(Acyl carrier protein) reductase - - - - - - - - - - - - adh_short_C2 k59_670523_1 436308.Nmar_0101 1.52e-59 202.0 COG0464@1|root,arCOG01308@2157|Archaea,41SB6@651137|Thaumarchaeota 651137|Thaumarchaeota O Cell division protein 48 (CDC48), domain 2 - - - ko:K13525 ko04141,ko05134,map04141,map05134 M00400,M00403 - - ko00000,ko00001,ko00002,ko03019,ko04131,ko04147 3.A.16.1 - - AAA,CDC48_2,CDC48_N k59_1069224_1 288000.BBta_7137 6.34e-30 119.0 COG0583@1|root,COG0583@2|Bacteria,1MWY0@1224|Proteobacteria,2TSD9@28211|Alphaproteobacteria,3JRI1@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria K Bacterial regulatory helix-turn-helix protein, lysR family MA20_19295 - - ko:K03566 ko02026,map02026 - - - ko00000,ko00001,ko03000 - - - HTH_1,LysR_substrate k59_781957_1 983544.Lacal_1689 1.59e-98 291.0 COG0300@1|root,COG0300@2|Bacteria,4NEFB@976|Bacteroidetes,1HX0Q@117743|Flavobacteriia 976|Bacteroidetes S Belongs to the short-chain dehydrogenases reductases (SDR) family - - - - - - - - - - - - adh_short k59_1410347_2 1500893.JQNB01000001_gene2381 4.88e-54 178.0 COG3496@1|root,COG3496@2|Bacteria,1RC56@1224|Proteobacteria,1RRT8@1236|Gammaproteobacteria,1X449@135614|Xanthomonadales 135614|Xanthomonadales S Protein of unknown function (DUF1365) - - - ko:K09701 - - - - ko00000 - - - DUF1365 k59_1122191_1 1229909.NSED_01300 3.68e-130 380.0 COG1005@1|root,arCOG01546@2157|Archaea,41SAT@651137|Thaumarchaeota 651137|Thaumarchaeota C NADH dehydrogenase - - 1.6.5.3 ko:K00337 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - NADHdh k59_220607_1 439292.Bsel_1005 3.67e-36 140.0 COG0591@1|root,COG0591@2|Bacteria,1TPVE@1239|Firmicutes,4H9KW@91061|Bacilli,26P0I@186821|Sporolactobacillaceae 91061|Bacilli E Sodium:solute symporter family - - - ko:K11928 - - - - ko00000,ko02000 2.A.21.2 - - SSF k59_393380_1 1122137.AQXF01000004_gene1762 2.39e-205 581.0 COG2759@1|root,COG2759@2|Bacteria,1MUR8@1224|Proteobacteria,2TRMM@28211|Alphaproteobacteria 28211|Alphaproteobacteria H Belongs to the formate--tetrahydrofolate ligase family fhs - 6.3.4.3 ko:K01938 ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200 M00140,M00377 R00943 RC00026,RC00111 ko00000,ko00001,ko00002,ko01000 - - - FTHFS k59_555394_3 523794.Lebu_1887 3.21e-09 63.5 COG0358@1|root,COG0358@2|Bacteria,3790T@32066|Fusobacteria 32066|Fusobacteria L RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication dnaG - - ko:K02316 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB_bind,Toprim_2,Toprim_N,zf-CHC2 k59_1291575_2 1144307.PMI04_03713 9.73e-26 106.0 COG1989@1|root,COG1989@2|Bacteria,1MUZF@1224|Proteobacteria,2UAW0@28211|Alphaproteobacteria,2K2UB@204457|Sphingomonadales 204457|Sphingomonadales NOU Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue gspO - 3.4.23.43 ko:K02654 - M00331 - - ko00000,ko00002,ko01000,ko01002,ko02035,ko02044 3.A.15.2 - - DiS_P_DiS,Peptidase_A24 k59_1291575_3 1122137.AQXF01000005_gene1359 2.72e-188 552.0 COG2182@1|root,COG2182@2|Bacteria,1MU3H@1224|Proteobacteria,2U0ZI@28211|Alphaproteobacteria 28211|Alphaproteobacteria G Extracellular solute-binding protein - - - - - - - - - - - - - k59_393392_1 1537994.JQFW01000057_gene570 7.77e-08 58.9 COG0612@1|root,COG0612@2|Bacteria,1MVST@1224|Proteobacteria,1RN05@1236|Gammaproteobacteria,46ABX@72275|Alteromonadaceae 1236|Gammaproteobacteria S Insulinase (Peptidase family M16) pqqL - - ko:K07263 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M16,Peptidase_M16_C k59_393397_1 436308.Nmar_1583 3.59e-102 305.0 COG1270@1|root,arCOG04274@2157|Archaea,41S6I@651137|Thaumarchaeota 651137|Thaumarchaeota H Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group cobD - 6.3.1.10 ko:K02227 ko00860,ko01100,map00860,map01100 M00122 R06529,R07302 RC00090,RC00096 ko00000,ko00001,ko00002,ko01000 - - - CobD_Cbib k59_1522591_1 911045.PSE_4539 6.45e-34 122.0 COG3005@1|root,COG3005@2|Bacteria,1MWV2@1224|Proteobacteria,2TURW@28211|Alphaproteobacteria 28211|Alphaproteobacteria C Cytochrome c-type protein - - - ko:K02569 - - - - ko00000 - - - Cytochrom_NNT k59_670546_1 377629.TERTU_0705 1.62e-89 278.0 COG4108@1|root,COG4108@2|Bacteria,1MU7X@1224|Proteobacteria,1RMFT@1236|Gammaproteobacteria,2PMPK@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria J Class II release factor RF3, C-terminal domain prfC GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003676,GO:0003723,GO:0003747,GO:0003824,GO:0003924,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008079,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0016150,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019003,GO:0019538,GO:0022411,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0032984,GO:0034641,GO:0034645,GO:0036094,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0071840,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - ko:K02837 - - - - ko00000,ko03012 - - - GTP_EFTU,GTP_EFTU_D2,RF3_C k59_336321_1 1132855.KB913035_gene971 4.77e-71 226.0 COG1104@1|root,COG1104@2|Bacteria,1MU1C@1224|Proteobacteria,2VH91@28216|Betaproteobacteria,2KM7T@206350|Nitrosomonadales 206350|Nitrosomonadales E Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins iscS - 2.8.1.7 ko:K04487 ko00730,ko01100,ko04122,map00730,map01100,map04122 - R07460,R11528,R11529 RC01789,RC02313 ko00000,ko00001,ko01000,ko02048,ko03016,ko03029 - - - Aminotran_5 k59_1236726_1 667632.KB890179_gene106 1.14e-109 350.0 COG1014@1|root,COG4231@1|root,COG1014@2|Bacteria,COG4231@2|Bacteria,1MUKS@1224|Proteobacteria,2VJGC@28216|Betaproteobacteria,1K37E@119060|Burkholderiaceae 28216|Betaproteobacteria C oxidoreductase porG - 1.2.7.8 ko:K04090 - - - - br01601,ko00000,ko01000 - - - POR,TPP_enzyme_C k59_278695_1 656024.FsymDg_3334 3.81e-24 102.0 COG2256@1|root,COG2256@2|Bacteria,2GKDP@201174|Actinobacteria,4ERXK@85013|Frankiales 201174|Actinobacteria L AAA ATPase, central domain protein rarA - - ko:K07478 - - - - ko00000 - - - AAA,AAA_assoc_2,MgsA_C,RuvB_N k59_278695_2 1410674.JNKU01000002_gene2343 1.62e-25 106.0 COG0173@1|root,COG0173@2|Bacteria,1TPCN@1239|Firmicutes,4HACD@91061|Bacilli,3F4PE@33958|Lactobacillaceae 91061|Bacilli J Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp) aspS - 6.1.1.12 ko:K01876 ko00970,map00970 M00359,M00360 R05577 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - GAD,tRNA-synt_2,tRNA_anti-codon k59_444299_1 648757.Rvan_1803 1.05e-84 271.0 COG1387@1|root,COG1387@2|Bacteria,1R4SE@1224|Proteobacteria,2U0Q5@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Histidinol phosphatase and related hydrolases of the PHP family - - - - - - - - - - - - - k59_1410370_1 1123400.KB904802_gene3151 6.23e-85 263.0 COG0427@1|root,COG0427@2|Bacteria,1MUGE@1224|Proteobacteria,1RWFB@1236|Gammaproteobacteria,462CD@72273|Thiotrichales 72273|Thiotrichales C Acetyl-CoA hydrolase/transferase N-terminal domain - - - ko:K18288 ko00660,map00660 - R02407,R10600 RC00012,RC00014 ko00000,ko00001,ko01000 - - - AcetylCoA_hyd_C,AcetylCoA_hydro k59_841422_1 1125863.JAFN01000001_gene3206 1.05e-36 139.0 COG2159@1|root,COG2159@2|Bacteria,1QZ3W@1224|Proteobacteria,42PKB@68525|delta/epsilon subdivisions,2WM59@28221|Deltaproteobacteria 28221|Deltaproteobacteria L PFAM transposase, IS4 family protein - - - - - - - - - - - - DDE_Tnp_1_4 k59_670557_1 1122194.AUHU01000001_gene10 5.32e-96 296.0 COG1457@1|root,COG1457@2|Bacteria,1NGY9@1224|Proteobacteria,1RNK5@1236|Gammaproteobacteria,465U5@72275|Alteromonadaceae 1236|Gammaproteobacteria F COG1457 Purine-cytosine permease and related proteins - - - - - - - - - - - - - k59_109072_1 1121013.P873_09280 6.35e-33 125.0 COG3386@1|root,COG3386@2|Bacteria,1RE3R@1224|Proteobacteria,1T2II@1236|Gammaproteobacteria,1XD6C@135614|Xanthomonadales 135614|Xanthomonadales G PFAM SMP-30 Gluconolaconase - - - - - - - - - - - - - k59_841426_1 1384056.N787_06720 1.85e-24 99.8 COG2755@1|root,COG2755@2|Bacteria,1RE1B@1224|Proteobacteria,1S3DM@1236|Gammaproteobacteria,1X613@135614|Xanthomonadales 135614|Xanthomonadales E Lysophospholipase L1 and related esterases - - - - - - - - - - - - Lipase_GDSL_2 k59_841426_2 1121405.dsmv_2209 2.45e-15 79.0 COG0045@1|root,COG1042@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,1MW98@1224|Proteobacteria,42NET@68525|delta/epsilon subdivisions,2WKDX@28221|Deltaproteobacteria,2MJA1@213118|Desulfobacterales 28221|Deltaproteobacteria C CoA binding domain - - 6.2.1.13 ko:K01905,ko:K22224 ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120 - R00229,R00920 RC00004,RC00012,RC00014 ko00000,ko00001,ko01000,ko01004 - - - ATP-grasp_5,CoA_binding_2,Succ_CoA_lig k59_1122231_1 1504672.669784905 4.62e-71 237.0 COG1129@1|root,COG4177@1|root,COG1129@2|Bacteria,COG4177@2|Bacteria,1R9IW@1224|Proteobacteria,2VKMT@28216|Betaproteobacteria,4AK08@80864|Comamonadaceae 28216|Betaproteobacteria P Belongs to the binding-protein-dependent transport system permease family - - - ko:K01998 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - ABC_tran,BCA_ABC_TP_C,BPD_transp_2 k59_618563_1 981384.AEYW01000001_gene1549 4.67e-82 260.0 COG1858@1|root,COG1858@2|Bacteria,1MV70@1224|Proteobacteria,2U451@28211|Alphaproteobacteria 28211|Alphaproteobacteria P cytochrome c peroxidase - - 1.11.1.5 ko:K00428 - - - - ko00000,ko01000 - - - CCP_MauG,Cytochrom_C k59_499605_1 82996.sch_20250 9.02e-42 156.0 COG1233@1|root,COG1233@2|Bacteria,1MXNP@1224|Proteobacteria,1RY0P@1236|Gammaproteobacteria,40057@613|Serratia 1236|Gammaproteobacteria Q Spermidine dehydrogenase - - 1.5.99.6 ko:K00316 ko00330,ko00410,ko01100,map00330,map00410,map01100 - R01914,R01915 RC00053,RC00225 ko00000,ko00001,ko01000 - - - Amino_oxidase,NAD_binding_8 k59_781989_2 1305737.JAFX01000001_gene322 6.73e-28 112.0 COG2355@1|root,COG2355@2|Bacteria,4NEBG@976|Bacteroidetes,47JZD@768503|Cytophagia 976|Bacteroidetes E Membrane dipeptidase (Peptidase family M19) - - 3.4.13.19 ko:K01273 - - - - ko00000,ko00537,ko01000,ko01002,ko04147 - - - Peptidase_M19 k59_220658_1 1122137.AQXF01000002_gene106 2.27e-92 292.0 COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,2TR4E@28211|Alphaproteobacteria 28211|Alphaproteobacteria O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner lon - 3.4.21.53 ko:K01338 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - AAA,LON_substr_bdg,Lon_C k59_1699674_1 1122194.AUHU01000007_gene280 1.55e-35 128.0 COG0593@1|root,COG0593@2|Bacteria,1MVW6@1224|Proteobacteria,1RPJP@1236|Gammaproteobacteria,46796@72275|Alteromonadaceae 1236|Gammaproteobacteria L Belongs to the DnaA family. HdA subfamily hda GO:0000166,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006275,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008156,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010556,GO:0010558,GO:0010605,GO:0016020,GO:0017076,GO:0019219,GO:0019222,GO:0030174,GO:0030554,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032297,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0043531,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0045934,GO:0046483,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051052,GO:0051053,GO:0051171,GO:0051172,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0090329,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901363,GO:1901576,GO:2000104,GO:2000112,GO:2000113 - ko:K10763 - - - - ko00000,ko03032 - - - Bac_DnaA k59_1699674_2 1122194.AUHU01000004_gene1557 4.4e-06 50.1 COG0616@1|root,COG0616@2|Bacteria,1MUXE@1224|Proteobacteria,1RNYW@1236|Gammaproteobacteria,46415@72275|Alteromonadaceae 1236|Gammaproteobacteria OU COG0616 Periplasmic serine proteases (ClpP class) sppA GO:0003674,GO:0003824,GO:0004175,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006465,GO:0006508,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009987,GO:0010467,GO:0016020,GO:0016021,GO:0016485,GO:0016787,GO:0019538,GO:0031224,GO:0031226,GO:0034641,GO:0043170,GO:0043603,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0051604,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564 - ko:K04773 - - - - ko00000,ko01000,ko01002 - - - Peptidase_S49 k59_1078179_2 870187.Thini_1655 5.67e-35 141.0 COG0489@1|root,COG3206@1|root,COG0489@2|Bacteria,COG3206@2|Bacteria,1MVI9@1224|Proteobacteria,1RNB0@1236|Gammaproteobacteria,461WA@72273|Thiotrichales 72273|Thiotrichales D G-rich domain on putative tyrosine kinase - - - - - - - - - - - - AAA_31,GNVR,Wzz k59_1586492_1 1239962.C943_01963 4.11e-82 260.0 COG0028@1|root,COG0028@2|Bacteria,4NENG@976|Bacteroidetes,47KS8@768503|Cytophagia 976|Bacteroidetes EH TIGRFAM acetolactate synthase, large subunit, biosynthetic type - - 2.2.1.6,4.1.1.7 ko:K01576,ko:K01652 ko00290,ko00627,ko00650,ko00660,ko00770,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00290,map00627,map00650,map00660,map00770,map01100,map01110,map01120,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R01764,R02672,R03050,R04672,R04673,R08648 RC00027,RC00106,RC00595,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_118039_1 314254.OA2633_03741 1.45e-120 377.0 COG1629@1|root,COG4206@1|root,COG1629@2|Bacteria,COG4206@2|Bacteria,1QU0Y@1224|Proteobacteria,2TWDU@28211|Alphaproteobacteria,440TK@69657|Hyphomonadaceae 28211|Alphaproteobacteria P COG1629 Outer membrane receptor proteins, mostly Fe transport - - - - - - - - - - - - Plug,TonB_dep_Rec k59_174579_1 13690.CP98_01820 1.17e-37 134.0 2BQU6@1|root,32JQY@2|Bacteria,1PDNY@1224|Proteobacteria,2VDN7@28211|Alphaproteobacteria,2K5JU@204457|Sphingomonadales 204457|Sphingomonadales - - - - - - - - - - - - - - DUF2889 k59_174579_2 1144307.PMI04_03283 5.16e-62 201.0 COG0183@1|root,COG0183@2|Bacteria,1MUZV@1224|Proteobacteria,2TV6F@28211|Alphaproteobacteria,2K20Q@204457|Sphingomonadales 204457|Sphingomonadales I acetyl-coa acetyltransferase - - - - - - - - - - - - - k59_400385_1 436308.Nmar_0088 6.93e-127 387.0 COG1201@1|root,arCOG00557@2157|Archaea,41S8P@651137|Thaumarchaeota 651137|Thaumarchaeota L DEAD/H associated - - - ko:K03724 - - - - ko00000,ko01000,ko03400 - - - DEAD,DEAD_assoc,Helicase_C k59_1643331_1 1458357.BG58_04230 9.74e-41 154.0 COG2373@1|root,COG2373@2|Bacteria,1MV7J@1224|Proteobacteria,2VI2R@28216|Betaproteobacteria,1K2DM@119060|Burkholderiaceae 28216|Betaproteobacteria S PFAM alpha-2-macroglobulin domain protein - - - ko:K06894 - - - - ko00000 - - - A2M,A2M_N,A2M_N_2,MG1 k59_795979_1 1229909.NSED_06145 2.62e-10 62.0 arCOG10571@1|root,arCOG10571@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_795979_2 1229909.NSED_06140 1.42e-123 358.0 COG0730@1|root,arCOG02050@2157|Archaea,41SKY@651137|Thaumarchaeota 651137|Thaumarchaeota S membrane transporter protein - - - ko:K07090 - - - - ko00000 - - - TauE k59_795979_3 1229909.NSED_06135 1.26e-17 77.4 arCOG10570@1|root,arCOG10570@2157|Archaea,41T75@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_118046_1 998088.B565_1194 2.12e-151 452.0 COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,1RPM5@1236|Gammaproteobacteria,1Y52N@135624|Aeromonadales 135624|Aeromonadales I Domain of unknown function (DUF1974) - - - ko:K06445 ko00071,ko01100,ko01212,map00071,map01100,map01212 M00087 R01175,R01279,R03777,R03857,R03990,R04751,R04754 RC00052,RC00076 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_N,DUF1974 k59_852406_1 861299.J421_0371 5.99e-53 181.0 COG4225@1|root,COG4225@2|Bacteria 2|Bacteria S unsaturated chondroitin disaccharide hydrolase activity - - 3.2.1.172 ko:K15532 - - - - ko00000,ko01000 - GH105 - Glyco_hydro_88 k59_61675_1 1370122.JHXQ01000002_gene2745 1.66e-13 72.4 COG0784@1|root,COG4191@1|root,COG0784@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TQQ9@28211|Alphaproteobacteria,4B7V6@82115|Rhizobiaceae 28211|Alphaproteobacteria T Histidine kinase cckA - 2.7.13.3 ko:K13587 ko02020,ko04112,map02020,map04112 M00512 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA,PAS,PAS_4,PAS_8,PAS_9,Response_reg k59_61675_2 1189612.A33Q_4672 9.78e-40 139.0 COG2080@1|root,COG2080@2|Bacteria,4NM72@976|Bacteroidetes 976|Bacteroidetes C Aerobic-type carbon monoxide dehydrogenase small subunit CoxS - - 1.3.99.16 ko:K07302 - - - - ko00000,ko01000 - - - Fer2,Fer2_2 k59_61675_3 935840.JAEQ01000015_gene3700 1.42e-13 72.0 COG1529@1|root,COG1529@2|Bacteria,1QTTJ@1224|Proteobacteria,2TQVK@28211|Alphaproteobacteria,43J9I@69277|Phyllobacteriaceae 28211|Alphaproteobacteria C Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain - - 1.3.99.16 ko:K07303 - - - - ko00000,ko01000 - - - Ald_Xan_dh_C,Ald_Xan_dh_C2 k59_456885_1 365046.Rta_31630 4.56e-31 112.0 2FGH6@1|root,348D3@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_1247804_1 123899.JPQP01000020_gene1988 1.49e-64 211.0 COG0144@1|root,COG0144@2|Bacteria,1MWPE@1224|Proteobacteria,2VI4V@28216|Betaproteobacteria,3T1ZE@506|Alcaligenaceae 28216|Betaproteobacteria J Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA sun - 2.1.1.176 ko:K03500 - - - - ko00000,ko01000,ko03009 - - - Methyltr_RsmB-F,NusB k59_4921_1 316407.85675414 2.27e-113 346.0 COG0280@1|root,COG0281@1|root,COG0280@2|Bacteria,COG0281@2|Bacteria,1MU0A@1224|Proteobacteria,1RN5F@1236|Gammaproteobacteria,3XNEY@561|Escherichia 1236|Gammaproteobacteria C malate dehydrogenase (decarboxylating) (NADP+) activity maeB GO:0003674,GO:0003824,GO:0004470,GO:0004473,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016614,GO:0016615,GO:0016616,GO:0030145,GO:0043167,GO:0043169,GO:0046872,GO:0046914,GO:0055114 1.1.1.38,1.1.1.40 ko:K00027,ko:K00029 ko00620,ko00710,ko01100,ko01120,ko01200,ko02020,map00620,map00710,map01100,map01120,map01200,map02020 M00169,M00172 R00214,R00216 RC00105 ko00000,ko00001,ko00002,ko01000 - - - Malic_M,PTA_PTB,malic k59_1586510_1 330214.NIDE3722 4.08e-95 283.0 COG1692@1|root,COG1692@2|Bacteria,3J0JW@40117|Nitrospirae 40117|Nitrospirae S YmdB-like protein - - - ko:K09769 - - - - ko00000 - - - YmdB k59_852415_1 702113.PP1Y_AT12081 5.75e-46 162.0 COG0370@1|root,COG0370@2|Bacteria,1MUZC@1224|Proteobacteria,2TQSU@28211|Alphaproteobacteria,2K0AQ@204457|Sphingomonadales 204457|Sphingomonadales P Ferrous iron transport protein B feoB - - ko:K04759 - - - - ko00000,ko02000 9.A.8.1 - - FeoB_C,FeoB_N,Gate k59_852415_2 158500.BV97_03860 2.03e-24 96.3 COG0629@1|root,COG0629@2|Bacteria,1RCWT@1224|Proteobacteria,2U5BZ@28211|Alphaproteobacteria,2K464@204457|Sphingomonadales 204457|Sphingomonadales L Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism - - - ko:K03111 ko03030,ko03430,ko03440,map03030,map03430,map03440 - - - ko00000,ko00001,ko03029,ko03032,ko03400 - - - SSB k59_1699698_1 1121912.AUHD01000006_gene1308 4.1e-104 323.0 COG0280@1|root,COG0281@1|root,COG0280@2|Bacteria,COG0281@2|Bacteria,4NFUJ@976|Bacteroidetes,1HXS7@117743|Flavobacteriia 976|Bacteroidetes C Malic enzyme maeB - 1.1.1.38,1.1.1.40 ko:K00027,ko:K00029 ko00620,ko00710,ko01100,ko01120,ko01200,ko02020,map00620,map00710,map01100,map01120,map01200,map02020 M00169,M00172 R00214,R00216 RC00105 ko00000,ko00001,ko00002,ko01000 - - - Malic_M,PTA_PTB,malic k59_1078204_2 502025.Hoch_2050 7.65e-206 585.0 COG2308@1|root,COG2308@2|Bacteria,1MUAD@1224|Proteobacteria,42MA8@68525|delta/epsilon subdivisions,2WIXR@28221|Deltaproteobacteria,2YUA9@29|Myxococcales 28221|Deltaproteobacteria S Circularly permuted ATP-grasp type 2 - - - - - - - - - - - - CP_ATPgrasp_2 k59_852428_1 926690.KE386573_gene2745 3.12e-40 152.0 COG0028@1|root,arCOG01998@2157|Archaea,2XUC7@28890|Euryarchaeota,23TX7@183963|Halobacteria 183963|Halobacteria E COG0028 Thiamine pyrophosphate-requiring enzymes acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase - - - - - - - - - - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_1417038_1 13690.CP98_04435 7.64e-164 469.0 COG1566@1|root,COG1566@2|Bacteria,1MU7I@1224|Proteobacteria,2TS39@28211|Alphaproteobacteria,2K1WC@204457|Sphingomonadales 204457|Sphingomonadales V Secretion protein, HlyD vceA - - ko:K03543 - M00701 - - ko00000,ko00002,ko02000 8.A.1.1 - - Biotin_lipoyl_2,HlyD,HlyD_3,HlyD_D23 k59_344141_1 158500.BV97_01462 4.7e-105 317.0 COG0845@1|root,COG0845@2|Bacteria,1MU78@1224|Proteobacteria,2TSW4@28211|Alphaproteobacteria,2K1BG@204457|Sphingomonadales 204457|Sphingomonadales M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - ko:K03585 ko01501,ko01503,map01501,map01503 M00646,M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000,ko03036 2.A.6.2,8.A.1.6 - - HlyD,HlyD_D23 k59_287671_1 1229909.NSED_06790 2.52e-54 179.0 COG1064@1|root,arCOG01455@2157|Archaea,41SK3@651137|Thaumarchaeota 651137|Thaumarchaeota C PFAM Alcohol dehydrogenase - - 1.1.1.1 ko:K13953 ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220 - R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310 RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273 ko00000,ko00001,ko01000 - - - ADH_N,ADH_zinc_N k59_61687_1 247634.GPB2148_1109 1.35e-82 257.0 COG0661@1|root,COG0661@2|Bacteria,1MW1J@1224|Proteobacteria,1RYAY@1236|Gammaproteobacteria,1J9DN@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S ABC1 family - - - - - - - - - - - - ABC1 k59_739752_1 377629.TERTU_0105 1.35e-101 311.0 COG4147@1|root,COG4147@2|Bacteria,1MVJ8@1224|Proteobacteria,1RN0R@1236|Gammaproteobacteria,2PN3I@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria S Sodium:solute symporter family actP - - ko:K14393 - - - - ko00000,ko02000 2.A.21.7 - - SSF k59_1134824_1 330214.NIDE0325 3.63e-42 150.0 COG1236@1|root,COG1236@2|Bacteria,3J0FD@40117|Nitrospirae 40117|Nitrospirae J Beta-Casp domain - - - ko:K07576 - - - - ko00000 - - - Beta-Casp,Lactamase_B,RMMBL k59_1134824_2 330214.NIDE0324 1.69e-40 146.0 COG3191@1|root,COG3191@2|Bacteria 2|Bacteria EQ aminopeptidase activity dmpA - 3.4.11.19 ko:K01266 - - - - ko00000,ko01000,ko01002 - - - Peptidase_S58 k59_1530222_1 702113.PP1Y_AT21864 1.24e-95 301.0 COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,2TWGU@28211|Alphaproteobacteria,2KEQG@204457|Sphingomonadales 204457|Sphingomonadales C Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain - - - - - - - - - - - - Ald_Xan_dh_C,Ald_Xan_dh_C2 k59_1699737_1 1122137.AQXF01000006_gene725 4.96e-70 234.0 COG1196@1|root,COG1196@2|Bacteria,1MVEP@1224|Proteobacteria,2TR50@28211|Alphaproteobacteria 28211|Alphaproteobacteria D domain, Protein - - - - - - - - - - - - Apolipoprotein k59_1643376_2 314225.ELI_05490 6.91e-38 137.0 COG1304@1|root,COG1304@2|Bacteria,1MUEZ@1224|Proteobacteria,2TQNW@28211|Alphaproteobacteria,2K18M@204457|Sphingomonadales 204457|Sphingomonadales C Dehydrogenase - - 1.1.2.3,1.1.99.31 ko:K00101,ko:K15054 ko00620,ko00627,ko01100,ko01120,map00620,map00627,map01100,map01120 - R00196,R04160,R07664 RC00044,RC00240 ko00000,ko00001,ko01000 - - - FMN_dh k59_852451_1 322710.Avin_06540 1.35e-36 127.0 COG0629@1|root,COG0629@2|Bacteria,1RCWT@1224|Proteobacteria,1S3WP@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism ssb GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0005488,GO:0006139,GO:0006259,GO:0006260,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901576 - ko:K03111 ko03030,ko03430,ko03440,map03030,map03430,map03440 - - - ko00000,ko00001,ko03029,ko03032,ko03400 - - - SSB k59_852451_2 247634.GPB2148_1084 2.54e-19 90.1 COG0477@1|root,COG2814@2|Bacteria,1MVSH@1224|Proteobacteria,1RN70@1236|Gammaproteobacteria 1236|Gammaproteobacteria EGP Major facilitator superfamily yajR GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944 - - - - - - - - - - MFS_1,Sugar_tr k59_1191441_1 102232.GLO73106DRAFT_00019640 5.54e-33 130.0 COG5640@1|root,COG5640@2|Bacteria,1G5D3@1117|Cyanobacteria 1117|Cyanobacteria O PFAM Trypsin - - - - - - - - - - - - HemolysinCabind,Trypsin k59_1473854_1 1122137.AQXF01000001_gene2848 6.42e-86 258.0 COG2086@1|root,COG2086@2|Bacteria,1MVH6@1224|Proteobacteria,2TR4J@28211|Alphaproteobacteria 28211|Alphaproteobacteria C Electron transfer flavoprotein etfB GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009987,GO:0016491,GO:0022900,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0055114 - ko:K03521 - - - - ko00000 - - - ETF k59_739755_1 436308.Nmar_1645 1.85e-21 88.2 COG3398@1|root,arCOG02611@2157|Archaea,41T7Q@651137|Thaumarchaeota 651137|Thaumarchaeota K Winged helix-turn-helix DNA-binding - - - - - - - - - - - - HTH_24 k59_739755_2 436308.Nmar_1644 1.42e-41 148.0 arCOG08728@1|root,arCOG08728@2157|Archaea,41SW1@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1022297_1 1047013.AQSP01000139_gene2329 7.47e-66 220.0 COG2091@1|root,COG2091@2|Bacteria 2|Bacteria H lysine biosynthetic process via aminoadipic acid - - - - - - - - - - - - CBM9_1 k59_626275_1 158500.BV97_02282 3.59e-44 156.0 COG1668@1|root,COG1668@2|Bacteria,1MWAS@1224|Proteobacteria,2TU2K@28211|Alphaproteobacteria,2K1E9@204457|Sphingomonadales 204457|Sphingomonadales CP ABC-type Na efflux pump, permease component - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_3 k59_626275_2 1088721.NSU_1881 7.88e-87 264.0 COG4152@1|root,COG4152@2|Bacteria,1QUPV@1224|Proteobacteria,2TW40@28211|Alphaproteobacteria,2JZWA@204457|Sphingomonadales 204457|Sphingomonadales S ABC transporter, ATP-binding protein - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_852455_1 366394.Smed_5626 9.65e-32 122.0 COG3637@1|root,COG3637@2|Bacteria,1R3Z1@1224|Proteobacteria,2U1SQ@28211|Alphaproteobacteria,4BAX2@82115|Rhizobiaceae 28211|Alphaproteobacteria M Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety - - - - - - - - - - - - OMP_b-brl k59_1191453_1 365528.KB891230_gene1968 2.78e-26 114.0 COG2843@1|root,COG2843@2|Bacteria,2GK15@201174|Actinobacteria,4ETXZ@85013|Frankiales 201174|Actinobacteria M Bacterial capsule synthesis protein PGA_cap - - - ko:K07282 - - - - ko00000 - - - PGA_cap k59_513270_1 1123518.ARWI01000001_gene1639 7.19e-36 140.0 COG2132@1|root,COG2132@2|Bacteria,1PM6Q@1224|Proteobacteria,1RRZJ@1236|Gammaproteobacteria 1236|Gammaproteobacteria Q Parallel beta-helix repeats - - - - - - - - - - - - Cu-oxidase_3 k59_682701_1 1122135.KB893134_gene3308 2.78e-67 214.0 COG5285@1|root,COG5285@2|Bacteria,1Q78R@1224|Proteobacteria,2TSX3@28211|Alphaproteobacteria 28211|Alphaproteobacteria Q Phytanoyl-CoA dioxygenase (PhyH) - - - - - - - - - - - - PhyH k59_287696_1 1301098.PKB_2721 1.54e-60 196.0 COG1250@1|root,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,1RY2T@1236|Gammaproteobacteria 1236|Gammaproteobacteria I Dehydrogenase paaH - 1.1.1.157 ko:K00074 ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120 - R01976,R05576,R06941 RC00029,RC00117 ko00000,ko00001,ko01000 - - - 3HCDH,3HCDH_N k59_965281_1 377629.TERTU_0883 3.08e-87 287.0 COG0085@1|root,COG0085@2|Bacteria,1MUC4@1224|Proteobacteria,1RMK0@1236|Gammaproteobacteria,2PMMQ@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria K RNA polymerase beta subunit external 1 domain rpoB GO:0000428,GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0030880,GO:0032774,GO:0032991,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234 2.7.7.6 ko:K03043 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7 k59_908670_1 384765.SIAM614_02596 1.47e-174 503.0 COG3653@1|root,COG3653@2|Bacteria,1MWWY@1224|Proteobacteria,2TT5E@28211|Alphaproteobacteria 28211|Alphaproteobacteria Q COG3653 N-acyl-D-aspartate D-glutamate deacylase - - - - - - - - - - - - Amidohydro_3 k59_1699764_1 316407.85676152 5.61e-54 177.0 COG0697@1|root,2Z7ID@2|Bacteria,1MXB3@1224|Proteobacteria,1RQV6@1236|Gammaproteobacteria,3XPC7@561|Escherichia 1236|Gammaproteobacteria EG Uptake of L-rhamnose across the boundary membrane with the concomitant transport of protons into the cell (symport system) rhaT GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0008643,GO:0008645,GO:0015291,GO:0015293,GO:0015749,GO:0015762,GO:0016020,GO:0022804,GO:0022857,GO:0034219,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944 - ko:K02856 - - - - ko00000,ko02000 2.A.7.6 - iECSE_1348.ECSE_4196,iEcE24377_1341.EcE24377A_4438,iYL1228.KPN_04216 RhaT k59_1699764_2 199310.c4856 1.2e-64 204.0 COG1917@1|root,COG4977@1|root,COG1917@2|Bacteria,COG4977@2|Bacteria,1QA56@1224|Proteobacteria,1RSI2@1236|Gammaproteobacteria,3XP90@561|Escherichia 1236|Gammaproteobacteria K Activates expression of the rhaSR operon in response to L-rhamnose rhaR GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031326,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1903506,GO:2000112,GO:2001141 - ko:K02854 - - - - ko00000,ko03000 - - - AraC_binding,HTH_18,HTH_AraC k59_1586557_1 1218084.BBJK01000057_gene4372 3.14e-32 126.0 COG0741@1|root,COG0741@2|Bacteria,1RAP3@1224|Proteobacteria,2VQXG@28216|Betaproteobacteria,1K1Z2@119060|Burkholderiaceae 28216|Betaproteobacteria M PFAM Lytic transglycosylase catalytic - - - - - - - - - - - - SLT k59_1586557_2 1150626.PHAMO_340124 1.34e-09 56.6 COG2164@1|root,COG2164@2|Bacteria,1N81P@1224|Proteobacteria,2UF42@28211|Alphaproteobacteria,2JUDT@204441|Rhodospirillales 204441|Rhodospirillales S Cyclophilin-like - - - - - - - - - - - - Cyclophil_like k59_1360863_1 1229909.NSED_09505 1.4e-07 52.0 COG0462@1|root,arCOG00067@2157|Archaea,41SH1@651137|Thaumarchaeota 651137|Thaumarchaeota F Ribose-phosphate pyrophosphokinase - - 2.7.6.1 ko:K00948 ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230 M00005 R01049 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - Pribosyl_synth,Pribosyltran,Pribosyltran_N k59_1360863_2 1229909.NSED_09510 1.42e-109 323.0 COG1041@1|root,arCOG00047@2157|Archaea 2157|Archaea L RNA methylase trmG10 GO:0000049,GO:0001510,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0004809,GO:0005488,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0140098,GO:0140101,GO:1901360,GO:1901363 2.1.1.213 ko:K07446 - - - - ko00000,ko01000,ko03016 - - - THUMP,UPF0020 k59_1756209_1 1122137.AQXF01000001_gene3185 1.9e-103 325.0 COG0249@1|root,COG0249@2|Bacteria,1MUGX@1224|Proteobacteria,2TQRR@28211|Alphaproteobacteria 28211|Alphaproteobacteria L that it carries out the mismatch recognition step. This protein has a weak ATPase activity mutS GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - ko:K03555 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V k59_1756209_2 1122137.AQXF01000001_gene3184 2.06e-16 77.8 COG0280@1|root,COG0281@1|root,COG0280@2|Bacteria,COG0281@2|Bacteria,1MU0A@1224|Proteobacteria,2TQJT@28211|Alphaproteobacteria 28211|Alphaproteobacteria C Malic enzyme tme - 1.1.1.40 ko:K00029 ko00620,ko00710,ko01100,ko01120,ko01200,map00620,map00710,map01100,map01120,map01200 M00169,M00172 R00216 RC00105 ko00000,ko00001,ko00002,ko01000 - - - Malic_M,PTA_PTB,malic k59_1022339_1 398527.Bphyt_2088 2.72e-67 222.0 COG0477@1|root,COG2814@2|Bacteria,1MVQQ@1224|Proteobacteria,2VNGH@28216|Betaproteobacteria,1KGJH@119060|Burkholderiaceae 28216|Betaproteobacteria EGP Uncharacterised MFS-type transporter YbfB - - - ko:K08369 - - - - ko00000,ko02000 2.A.1 - - MFS_1,MFS_4,Sugar_tr k59_513302_1 382464.ABSI01000009_gene3911 1.45e-27 120.0 COG3328@1|root,COG3328@2|Bacteria,46XKE@74201|Verrucomicrobia,2IW4N@203494|Verrucomicrobiae 2|Bacteria L MULE transposase domain - - - ko:K07493 - - - - ko00000 - - - Transposase_mut k59_1473893_1 261292.Nit79A3_2380 2.78e-39 132.0 COG0211@1|root,COG0211@2|Bacteria,1MZGH@1224|Proteobacteria,2VU4W@28216|Betaproteobacteria,373IF@32003|Nitrosomonadales 28216|Betaproteobacteria J Belongs to the bacterial ribosomal protein bL27 family rpmA - - ko:K02899 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L27 k59_1473893_2 511.JT27_08460 1.75e-48 157.0 COG0261@1|root,COG0261@2|Bacteria,1MZEW@1224|Proteobacteria,2VSHZ@28216|Betaproteobacteria,3T477@506|Alcaligenaceae 28216|Betaproteobacteria J This protein binds to 23S rRNA in the presence of protein L20 rplU - - ko:K02888 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L21p k59_682752_1 1122137.AQXF01000002_gene38 1.77e-103 311.0 COG0573@1|root,COG0573@2|Bacteria,1MVKP@1224|Proteobacteria,2TQU1@28211|Alphaproteobacteria 28211|Alphaproteobacteria P probably responsible for the translocation of the substrate across the membrane pstC - - ko:K02037 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - BPD_transp_1,DUF3708 k59_1247886_2 565045.NOR51B_1802 1.66e-82 261.0 COG1217@1|root,COG1217@2|Bacteria,1MV5Q@1224|Proteobacteria,1RMJB@1236|Gammaproteobacteria 1236|Gammaproteobacteria T GTP-binding protein TypA typA GO:0000027,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006996,GO:0008150,GO:0009266,GO:0009408,GO:0009409,GO:0009628,GO:0009987,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0042254,GO:0042255,GO:0042273,GO:0043933,GO:0044085,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0065003,GO:0070925,GO:0071826,GO:0071840 - ko:K06207 - - - - ko00000 - - - EFG_C,GTP_EFTU,GTP_EFTU_D2 k59_1134878_1 1408424.JHYI01000038_gene2459 2.95e-07 58.9 COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,1TR2N@1239|Firmicutes,4H9RR@91061|Bacilli,1ZB2Q@1386|Bacillus 91061|Bacilli EU peptidase yuxL - 3.4.19.1 ko:K01303 - - - - ko00000,ko01000,ko01002 - - - PD40,Peptidase_S9 k59_400467_1 1328313.DS2_13739 6.55e-78 273.0 COG3209@1|root,COG3209@2|Bacteria,1MVV1@1224|Proteobacteria,1RP75@1236|Gammaproteobacteria,465V0@72275|Alteromonadaceae 1236|Gammaproteobacteria M COG3209 Rhs family protein - - - - - - - - - - - - RHS_repeat k59_287720_2 1177154.Y5S_02568 1.73e-21 90.9 COG2135@1|root,COG2135@2|Bacteria,1RCCC@1224|Proteobacteria,1S39B@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Belongs to the SOS response-associated peptidase family - - - - - - - - - - - - SRAP k59_1473909_1 330214.NIDE2489 3.33e-52 179.0 28MEN@1|root,2ZASA@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_1022356_1 1278309.KB907101_gene342 1.85e-68 215.0 COG3384@1|root,COG3384@2|Bacteria,1MW77@1224|Proteobacteria,1RQIK@1236|Gammaproteobacteria,1XMT5@135619|Oceanospirillales 135619|Oceanospirillales S PFAM Extradiol ring-cleavage dioxygenase, class III - - 1.13.11.8 ko:K04101 ko00362,ko00624,ko00627,ko01120,map00362,map00624,map00627,map01120 - R01632,R03550,R04280,R09565 RC00233,RC00387,RC00535,RC02567,RC02694 br01602,ko00000,ko00001,ko01000 - - - LigB k59_288648_1 330214.NIDE0520 2.62e-99 294.0 COG0842@1|root,COG0842@2|Bacteria 2|Bacteria V Transport permease protein ycf38 - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane k59_1587393_1 1082932.ATCR1_07964 8.77e-27 105.0 COG0346@1|root,COG0346@2|Bacteria,1NU4U@1224|Proteobacteria,2UP4U@28211|Alphaproteobacteria,4BE4E@82115|Rhizobiaceae 28211|Alphaproteobacteria E lactoylglutathione lyase activity - - - - - - - - - - - - - k59_1767890_2 1081644.IMCC13023_03350 2.49e-37 136.0 COG0259@1|root,COG0259@2|Bacteria,2GJCR@201174|Actinobacteria,4FNX1@85023|Microbacteriaceae 201174|Actinobacteria H Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) pdxH GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006081,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0010181,GO:0016491,GO:0016614,GO:0016899,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0032553,GO:0034641,GO:0036094,GO:0042364,GO:0042802,GO:0042803,GO:0042816,GO:0042819,GO:0042822,GO:0042823,GO:0043167,GO:0043168,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046184,GO:0046483,GO:0046983,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 1.4.3.5 ko:K00275 ko00750,ko01100,ko01120,map00750,map01100,map01120 M00124 R00277,R00278,R01710,R01711 RC00048,RC00116 ko00000,ko00001,ko00002,ko01000 - - iNJ661.Rv2607 PNP_phzG_C,Putative_PNPOx k59_807939_1 477184.KYC_01495 5.4e-51 177.0 2EQS1@1|root,33IBX@2|Bacteria,1NJHD@1224|Proteobacteria,2W31Y@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_16799_1 1267534.KB906754_gene3786 2.59e-10 60.1 COG1960@1|root,COG1960@2|Bacteria,3Y2FM@57723|Acidobacteria,2JIVG@204432|Acidobacteriia 204432|Acidobacteriia I Acyl-CoA dehydrogenase, C-terminal domain - - 1.3.8.6 ko:K00252 ko00071,ko00310,ko00362,ko00380,ko01100,ko01120,ko01130,map00071,map00310,map00362,map00380,map01100,map01120,map01130 M00032 R02487,R02488,R10074 RC00052,RC00156 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_1259253_1 745014.OMB55_00015840 1.69e-95 292.0 COG5505@1|root,COG5505@2|Bacteria,1RAF4@1224|Proteobacteria 1224|Proteobacteria S integral membrane protein - - - - - - - - - - - - DUF819 k59_524406_1 1123321.KB905815_gene3150 1.18e-34 128.0 COG0350@1|root,COG0350@2|Bacteria,2GKA9@201174|Actinobacteria 201174|Actinobacteria L Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated ogt - 2.1.1.63 ko:K00567 - - - - ko00000,ko01000,ko03400 - - - DNA_binding_1,Methyltransf_1N k59_524406_2 644968.DFW101_1713 1.24e-53 183.0 COG0613@1|root,COG0613@2|Bacteria,1MWIH@1224|Proteobacteria,42N9R@68525|delta/epsilon subdivisions,2WN5P@28221|Deltaproteobacteria,2M85C@213115|Desulfovibrionales 28221|Deltaproteobacteria S SMART phosphoesterase PHP domain protein - - 3.1.3.97 ko:K07053 - - R00188,R11188 RC00078 ko00000,ko01000 - - - PHP k59_1316361_1 697282.Mettu_0319 7.93e-13 70.1 COG4966@1|root,COG4966@2|Bacteria,1R5YK@1224|Proteobacteria,1RZIZ@1236|Gammaproteobacteria,1XF4P@135618|Methylococcales 135618|Methylococcales NU Type IV Pilus-assembly protein W - - - ko:K02672 - - - - ko00000,ko02035,ko02044 - - - N_methyl,PilW k59_920461_1 1122137.AQXF01000001_gene3266 3.75e-170 484.0 COG0654@1|root,COG0654@2|Bacteria,1MU6I@1224|Proteobacteria,2TRZU@28211|Alphaproteobacteria 28211|Alphaproteobacteria CH Ubiquinone biosynthesis hydroxylase, UbiH UbiF VisC COQ6 family ubiH GO:0003674,GO:0003824,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016491,GO:0019168,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:1901576,GO:1901661,GO:1901663 - ko:K03185 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00117 R04989,R08773 RC02670 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_3 k59_1089841_1 398580.Dshi_0204 1.3e-64 220.0 COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,2TR78@28211|Alphaproteobacteria 28211|Alphaproteobacteria I acyl-CoA dehydrogenase mcd - 1.3.8.12 ko:K14448 ko00630,ko01120,ko01200,map00630,map01120,map01200 M00373 R09293 RC02483 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_1767925_1 702113.PP1Y_AT793 1.28e-61 197.0 2C7BT@1|root,33MZ9@2|Bacteria,1NMQ4@1224|Proteobacteria,2UG5B@28211|Alphaproteobacteria,2K40I@204457|Sphingomonadales 204457|Sphingomonadales - - - - - - - - - - - - - - Porin_4 k59_1146294_1 247639.MGP2080_06002 2.2e-79 260.0 COG1472@1|root,COG1472@2|Bacteria,1MVIV@1224|Proteobacteria,1RMA0@1236|Gammaproteobacteria 1236|Gammaproteobacteria G Belongs to the glycosyl hydrolase 3 family - - 3.2.1.21 ko:K05349 ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110 - R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040 RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248 ko00000,ko00001,ko01000 - GH3 - Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C k59_694524_1 273075.Ta0668 1.48e-08 62.0 COG0491@1|root,arCOG00498@2157|Archaea,2XTW0@28890|Euryarchaeota,241WV@183967|Thermoplasmata 183967|Thermoplasmata S Metallo-beta-lactamase superfamily - - - - - - - - - - - - Lactamase_B k59_74016_1 270374.MELB17_16653 8.8e-80 258.0 COG0348@1|root,COG3901@1|root,COG0348@2|Bacteria,COG3901@2|Bacteria,1MY5M@1224|Proteobacteria,1RNSU@1236|Gammaproteobacteria,465B0@72275|Alteromonadaceae 1236|Gammaproteobacteria CK Regulator of nitric oxide reductase transcription yccM GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K19339 - - - - ko00000,ko03000 - - - FMN_bind,Fer4,Fer4_5 k59_694528_1 224911.27351364 9.75e-48 174.0 COG2203@1|root,COG4191@1|root,COG2203@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TTJ0@28211|Alphaproteobacteria,3JS5D@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria T Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - - - - - - - - - - GAF,GAF_2,HAMP,HATPase_c,HisKA,PAS_7,dCache_1 k59_1542247_1 1340493.JNIF01000003_gene3557 3.09e-08 62.4 COG3386@1|root,COG4625@1|root,COG3386@2|Bacteria,COG4625@2|Bacteria 2|Bacteria T pathogenesis - - 1.15.1.1,3.4.21.50 ko:K01337,ko:K04565,ko:K20276,ko:K21449 ko02024,ko04146,ko04213,ko05014,ko05016,ko05020,map02024,map04146,map04213,map05014,map05016,map05020 - - - ko00000,ko00001,ko01000,ko01002,ko02000 1.B.40.2 - - Autotransporter,He_PIG,SGL k59_750903_1 34007.IT40_20955 1.02e-121 352.0 COG1484@1|root,COG1484@2|Bacteria,1MWQX@1224|Proteobacteria,2TRGY@28211|Alphaproteobacteria,2PW77@265|Paracoccus 28211|Alphaproteobacteria L IstB-like ATP binding protein - - - - - - - - - - - - IstB_IS21 k59_468482_1 1122225.AULQ01000008_gene1332 2.79e-107 325.0 COG3186@1|root,COG3186@2|Bacteria,4NEX5@976|Bacteroidetes,1HX7H@117743|Flavobacteriia 976|Bacteroidetes E Pfam Biopterin-dependent aromatic amino acid hydroxylase phhA - 1.14.16.1 ko:K00500 ko00360,ko00400,ko00790,ko01100,ko01230,map00360,map00400,map00790,map01100,map01230 - R01795,R07211 RC00490 ko00000,ko00001,ko01000 - - - Biopterin_H k59_976142_1 545693.BMQ_1993 3.45e-08 60.5 COG0614@1|root,COG0614@2|Bacteria,1UNE3@1239|Firmicutes,4H9ZX@91061|Bacilli,1ZBS8@1386|Bacillus 91061|Bacilli P COG0614 ABC-type Fe3 -hydroxamate transport system, periplasmic component yvrC - - ko:K02016 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko02000 3.A.1.14 - - Peripla_BP_2 k59_920496_1 1096930.L284_09985 9.76e-56 177.0 COG2151@1|root,COG2151@2|Bacteria,1MZ9Y@1224|Proteobacteria,2U72U@28211|Alphaproteobacteria,2K4IC@204457|Sphingomonadales 204457|Sphingomonadales S FeS assembly SUF system protein - - - - - - - - - - - - FeS_assembly_P k59_920496_2 1096930.L284_09990 2.77e-48 165.0 COG0520@1|root,COG0520@2|Bacteria,1MUPD@1224|Proteobacteria,2TRNY@28211|Alphaproteobacteria,2JZVI@204457|Sphingomonadales 204457|Sphingomonadales E Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine sufS - 2.8.1.7,4.4.1.16 ko:K11717 ko00450,ko01100,map00450,map01100 - R03599,R11528 RC00961,RC01789,RC02313 ko00000,ko00001,ko01000 - - - Aminotran_5 k59_864967_1 1040989.AWZU01000013_gene1661 5.39e-07 58.2 COG2114@1|root,COG3899@1|root,COG2114@2|Bacteria,COG3899@2|Bacteria,1MUDT@1224|Proteobacteria,2TQVN@28211|Alphaproteobacteria,3K3KW@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria T Adenylate and Guanylate cyclase catalytic domain - - - - - - - - - - - - AAA_16,DZR,Guanylate_cyc,SAM_1 k59_1316423_2 1122917.KB899659_gene5502 9.43e-24 98.2 COG0597@1|root,COG0597@2|Bacteria,1VA9R@1239|Firmicutes,4HIR4@91061|Bacilli,26XRJ@186822|Paenibacillaceae 91061|Bacilli MU This protein specifically catalyzes the removal of signal peptides from prolipoproteins lspA GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 3.4.23.36 ko:K03101 ko03060,map03060 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_A8 k59_468499_1 525257.HMPREF0204_11782 9.48e-05 50.4 COG2819@1|root,COG2819@2|Bacteria,4NN8M@976|Bacteroidetes,1I1EI@117743|Flavobacteriia,3ZUA9@59732|Chryseobacterium 976|Bacteroidetes S Putative esterase - - - ko:K07017 - - - - ko00000 - - - Esterase,TPR_8 k59_1373124_1 1121928.AUHE01000004_gene2605 3.44e-53 177.0 COG2030@1|root,COG2030@2|Bacteria,2GJJI@201174|Actinobacteria,4GEPI@85026|Gordoniaceae 201174|Actinobacteria I N-terminal half of MaoC dehydratase htdY - - - - - - - - - - - MaoC_dehydrat_N,MaoC_dehydratas k59_920520_1 1229909.NSED_09240 3.72e-130 372.0 COG0778@1|root,arCOG00288@2157|Archaea,41S7D@651137|Thaumarchaeota 651137|Thaumarchaeota C Cob(II)yrinic acid a,c-diamide reductase - - 1.13.11.79 ko:K04719 ko00740,ko01100,map00740,map01100 - R09083 RC00435,RC02413 ko00000,ko00001,ko01000 - - - Nitroreductase k59_1146343_1 1499967.BAYZ01000041_gene2364 1.32e-65 206.0 COG1012@1|root,COG1012@2|Bacteria 2|Bacteria C belongs to the aldehyde dehydrogenase family adhE GO:0003674,GO:0003824,GO:0004022,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006066,GO:0006067,GO:0006115,GO:0008150,GO:0008152,GO:0008774,GO:0009058,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0016620,GO:0016903,GO:0016999,GO:0017000,GO:0017144,GO:0034308,GO:0034309,GO:0042802,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0055114,GO:0071704,GO:1901576,GO:1901615,GO:1901617 1.1.1.1,1.2.1.10 ko:K04072 ko00010,ko00071,ko00350,ko00620,ko00625,ko00626,ko00650,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00620,map00625,map00626,map00650,map01100,map01110,map01120,map01130,map01220 - R00228,R00623,R00754,R01172,R04880,R05233,R05234,R06917,R06927 RC00004,RC00050,RC00088,RC00099,RC00116,RC00184,RC00649,RC01195 ko00000,ko00001,ko01000 - - iEcE24377_1341.EcE24377A_1389,iYL1228.KPN_02199 Aldedh,Fe-ADH k59_1486325_1 357804.Ping_3418 3.39e-26 108.0 COG0566@1|root,COG0566@2|Bacteria,1MWCM@1224|Proteobacteria,1RN2F@1236|Gammaproteobacteria,2QHBP@267894|Psychromonadaceae 1236|Gammaproteobacteria J Specifically methylates the ribose of guanosine 2251 in 23S rRNA rlmB GO:0000154,GO:0000451,GO:0000453,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070039,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.185 ko:K03218 - - - - ko00000,ko01000,ko03009 - - - SpoU_methylase,SpoU_sub_bind k59_299879_1 1195236.CTER_0534 8.01e-44 166.0 COG0265@1|root,COG0265@2|Bacteria,1TRM8@1239|Firmicutes,247M5@186801|Clostridia,3WI5G@541000|Ruminococcaceae 186801|Clostridia O PDZ domain (Also known as DHR or GLGF) degQ - 3.4.21.107 ko:K04771 ko01503,ko02020,map01503,map02020 M00728 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 - - - PDZ_2,Trypsin_2 k59_1711473_1 396588.Tgr7_2118 4.25e-34 125.0 COG0501@1|root,COG0501@2|Bacteria,1MUV4@1224|Proteobacteria,1RMN0@1236|Gammaproteobacteria,1WWI6@135613|Chromatiales 135613|Chromatiales O Belongs to the peptidase M48B family htpX - - ko:K03799 - M00743 - - ko00000,ko00002,ko01000,ko01002 - - - Peptidase_M48 k59_1711473_2 713586.KB900536_gene89 1.49e-11 64.7 COG2199@1|root,COG2200@1|root,COG2199@2|Bacteria,COG2200@2|Bacteria,1PJCA@1224|Proteobacteria,1RS4H@1236|Gammaproteobacteria,1WWNV@135613|Chromatiales 135613|Chromatiales T PFAM EAL domain - - - ko:K21025 ko02025,map02025 - - - ko00000,ko00001 - - - EAL,GGDEF,PAS,PAS_8,PAS_9,Response_reg k59_1089897_1 748247.AZKH_p0651 1.89e-73 246.0 COG1038@1|root,COG1038@2|Bacteria,1NW9R@1224|Proteobacteria,2VI52@28216|Betaproteobacteria,2KXS7@206389|Rhodocyclales 206389|Rhodocyclales C Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second - - 6.4.1.1 ko:K01958 ko00020,ko00620,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00720,map01100,map01120,map01200,map01230 M00173 R00344 RC00040,RC00367 ko00000,ko00001,ko00002,ko01000 - - - Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2,HMGL-like,PYC_OADA k59_581659_1 1211115.ALIQ01000189_gene810 8.75e-204 578.0 COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2TQR1@28211|Alphaproteobacteria,3NAEX@45404|Beijerinckiaceae 28211|Alphaproteobacteria C Aldehyde dehydrogenase family - - 1.2.1.3 ko:K00128 ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130 M00135 R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146 RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_581659_2 700598.Niako_0973 2.77e-15 79.3 COG3000@1|root,COG3000@2|Bacteria,4NFWX@976|Bacteroidetes,1IPCD@117747|Sphingobacteriia 976|Bacteroidetes I PFAM Fatty acid hydroxylase - - - - - - - - - - - - FA_hydroxylase k59_1316456_1 397278.JOJN01000001_gene2690 3.02e-11 62.4 COG0792@1|root,COG0792@2|Bacteria,2IQ3X@201174|Actinobacteria,4DRQN@85009|Propionibacteriales 201174|Actinobacteria L Belongs to the UPF0102 family yraN - - ko:K07460 - - - - ko00000 - - - UPF0102 k59_1316456_2 1120949.KB903356_gene8636 7.32e-28 110.0 COG0681@1|root,COG0681@2|Bacteria,2GIYN@201174|Actinobacteria,4DBDV@85008|Micromonosporales 201174|Actinobacteria U Belongs to the peptidase S26 family lepB - 3.4.21.89 ko:K03100 ko02024,ko03060,map02024,map03060 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_S24,Peptidase_S26 k59_1428718_1 1522072.IL54_4511 3.05e-150 441.0 COG5433@1|root,COG5433@2|Bacteria,1MY25@1224|Proteobacteria,2U0Y8@28211|Alphaproteobacteria,2K1SN@204457|Sphingomonadales 204457|Sphingomonadales L Transposase DDE domain group 1 - - - - - - - - - - - - DDE_Tnp_1_4 k59_129953_1 1415780.JPOG01000001_gene1027 7.99e-29 112.0 COG1825@1|root,COG1825@2|Bacteria,1RDH0@1224|Proteobacteria,1S46A@1236|Gammaproteobacteria,1X34R@135614|Xanthomonadales 135614|Xanthomonadales J This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance ctc GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02897 ko03010,map03010 M00178 - - ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L25p,Ribosomal_TL5_C k59_1711495_1 1117943.SFHH103_01787 4.56e-07 57.4 COG2114@1|root,COG2114@2|Bacteria,1NAJG@1224|Proteobacteria,2TSVT@28211|Alphaproteobacteria,4B9BJ@82115|Rhizobiaceae 28211|Alphaproteobacteria T Adenylate cyclase cyaH - - - - - - - - - - - Guanylate_cyc k59_864992_1 1499967.BAYZ01000197_gene3054 5.31e-62 205.0 COG4388@1|root,COG4388@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - Mu-like_Pro k59_16865_1 1209072.ALBT01000045_gene2620 6.16e-69 216.0 COG3789@1|root,COG3789@2|Bacteria,1RFUB@1224|Proteobacteria,1S5PM@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Uncharacterized protein conserved in bacteria (DUF2170) - - - ko:K09980 - - - - ko00000 - - - DUF2170 k59_1146391_1 1042377.AFPJ01000009_gene175 2.8e-54 176.0 COG1028@1|root,COG1028@2|Bacteria,1MU6X@1224|Proteobacteria,1RMBB@1236|Gammaproteobacteria,46560@72275|Alteromonadaceae 1236|Gammaproteobacteria IQ COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) fabG GO:0000166,GO:0003674,GO:0003824,GO:0004312,GO:0004316,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0016740,GO:0016746,GO:0016747,GO:0017144,GO:0018130,GO:0019752,GO:0030497,GO:0032787,GO:0034641,GO:0036094,GO:0042364,GO:0042802,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0048037,GO:0050661,GO:0050662,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0072330,GO:0097159,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 1.1.1.100 ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - iAF1260.b1093,iAPECO1_1312.APECO1_174,iBWG_1329.BWG_0941,iE2348C_1286.E2348C_1185,iEC55989_1330.EC55989_1205,iECABU_c1320.ECABU_c13060,iECDH10B_1368.ECDH10B_1165,iECDH1ME8569_1439.ECDH1ME8569_1028,iECED1_1282.ECED1_1236,iECIAI39_1322.ECIAI39_2068,iECNA114_1301.ECNA114_1150,iECO103_1326.ECO103_1138,iECOK1_1307.ECOK1_1200,iECP_1309.ECP_1085,iECS88_1305.ECS88_1107,iECSE_1348.ECSE_1157,iECSF_1327.ECSF_0992,iECUMN_1333.ECUMN_1268,iECW_1372.ECW_m1201,iEKO11_1354.EKO11_2741,iETEC_1333.ETEC_1158,iEcDH1_1363.EcDH1_2554,iEcE24377_1341.EcE24377A_1214,iEcHS_1320.EcHS_A1215,iEcSMS35_1347.EcSMS35_2034,iEcolC_1368.EcolC_2508,iG2583_1286.G2583_1353,iJN746.PP_1914,iJO1366.b1093,iJR904.b1093,iSBO_1134.SBO_1970,iSFV_1184.SFV_1113,iSF_1195.SF1097,iSFxv_1172.SFxv_1249,iSSON_1240.SSON_1113,iS_1188.S1177,iSbBS512_1146.SbBS512_E2231,iUMN146_1321.UM146_11860,iUMNK88_1353.UMNK88_1363,iUTI89_1310.UTI89_C1218,iWFL_1372.ECW_m1201,iY75_1357.Y75_RS05710 adh_short_C2 k59_1146391_3 1212548.B381_07191 4.69e-12 66.2 COG0115@1|root,COG0115@2|Bacteria,1MZAK@1224|Proteobacteria,1RPPG@1236|Gammaproteobacteria,1Z0EF@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria EH COG0115 Branched-chain amino acid aminotransferase 4-amino-4-deoxychorismate lyase pabC GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008696,GO:0009987,GO:0016829,GO:0016830,GO:0016833,GO:0019752,GO:0019842,GO:0030170,GO:0034641,GO:0036094,GO:0042558,GO:0043167,GO:0043168,GO:0043436,GO:0043603,GO:0044237,GO:0044281,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0070279,GO:0071704,GO:0097159,GO:1901360,GO:1901363,GO:1901564 4.1.3.38 ko:K02619 ko00790,map00790 - R05553 RC01843,RC02148 ko00000,ko00001,ko01000 - - iAPECO1_1312.APECO1_177,iE2348C_1286.E2348C_1188,iECED1_1282.ECED1_1239,iECNA114_1301.ECNA114_1153,iECOK1_1307.ECOK1_1203,iECS88_1305.ECS88_1110,iECSF_1327.ECSF_0995,iECUMN_1333.ECUMN_1273,iJN746.PP_1917,iPC815.YPO1603,iUMN146_1321.UM146_11845,iUTI89_1310.UTI89_C1222,ic_1306.c1366 Aminotran_4 k59_186748_1 436308.Nmar_1325 2.07e-69 225.0 arCOG07561@1|root,arCOG07561@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - TSP_3,VWA k59_1768041_1 1041139.KB902578_gene5319 3.79e-13 71.2 COG0249@1|root,COG0249@2|Bacteria,1MUGX@1224|Proteobacteria,2TQRR@28211|Alphaproteobacteria,4B761@82115|Rhizobiaceae 28211|Alphaproteobacteria L that it carries out the mismatch recognition step. This protein has a weak ATPase activity mutS GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - ko:K03555 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V k59_920581_1 566466.NOR53_428 7.23e-164 466.0 COG0050@1|root,COG0050@2|Bacteria,1MVC0@1224|Proteobacteria,1RMYX@1236|Gammaproteobacteria,1J5DE@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis tuf GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - ko:K02358 - - - - ko00000,ko03012,ko03029,ko04147 - - - GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3 k59_1204183_2 316407.1736699 3.69e-127 369.0 COG0079@1|root,COG0079@2|Bacteria,1MW7I@1224|Proteobacteria,1RP4T@1236|Gammaproteobacteria,3XN8C@561|Escherichia 1236|Gammaproteobacteria E Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily hisC GO:0000105,GO:0003674,GO:0003824,GO:0004400,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.6.1.9 ko:K00817 ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230 M00026 R00694,R00734,R03243 RC00006,RC00888 ko00000,ko00001,ko00002,ko01000,ko01007 - - iECO111_1330.ECO111_2745,iSDY_1059.SDY_2220,iSSON_1240.SSON_2092 Aminotran_1_2 k59_1204184_1 1123504.JQKD01000003_gene565 2.09e-40 142.0 COG0668@1|root,COG0668@2|Bacteria,1N2GE@1224|Proteobacteria,2WFQP@28216|Betaproteobacteria,4ABHJ@80864|Comamonadaceae 28216|Betaproteobacteria M PFAM Conserved TM helix repeat-containing protein - - - - - - - - - - - - TM_helix k59_1204184_2 316279.Syncc9902_0933 7.57e-07 52.0 COG0837@1|root,COG0837@2|Bacteria,1G1TJ@1117|Cyanobacteria,1GYCB@1129|Synechococcus 1117|Cyanobacteria H Belongs to the bacterial glucokinase family glk GO:0003674,GO:0003824,GO:0004340,GO:0004396,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016052,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017144,GO:0018130,GO:0019200,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044262,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046835,GO:0046939,GO:0051156,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576 2.7.1.2 ko:K00845 ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200 M00001,M00549 R00299,R01600,R01786 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - Glucokinase k59_1035616_1 1229909.NSED_09490 6.6e-167 477.0 COG0174@1|root,arCOG01909@2157|Archaea,41SD6@651137|Thaumarchaeota 651137|Thaumarchaeota E TIGRFAM glutamine synthetase, type I - - 6.3.1.2 ko:K01915 ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 - R00253 RC00010,RC02798 ko00000,ko00001,ko01000,ko04147 - - - Gln-synt_C,Gln-synt_N k59_977106_1 744872.Spica_0007 2.29e-21 97.8 COG0706@1|root,COG0706@2|Bacteria,2J5HA@203691|Spirochaetes 203691|Spirochaetes U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins yidC - - ko:K03217 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044,ko03029 2.A.9 - - 60KD_IMP,YidC_periplas k59_1487297_1 436308.Nmar_0402 6.07e-147 425.0 COG5253@1|root,arCOG04169@2157|Archaea,41S9X@651137|Thaumarchaeota 651137|Thaumarchaeota U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently secY - - ko:K03076 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5 - - Plug_translocon,SecY k59_130849_1 1537917.JU82_06680 3.21e-67 212.0 COG0586@1|root,COG0586@2|Bacteria,1MX4M@1224|Proteobacteria,42RMJ@68525|delta/epsilon subdivisions,2YMZV@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S PFAM SNARE associated Golgi protein dedA - - - - - - - - - - - SNARE_assoc k59_1712400_1 1125863.JAFN01000001_gene606 2.68e-88 271.0 COG3303@1|root,COG3303@2|Bacteria,1P8CP@1224|Proteobacteria,42MXS@68525|delta/epsilon subdivisions,2WJ68@28221|Deltaproteobacteria 28221|Deltaproteobacteria C Seven times multi-haem cytochrome CxxCH - - - - - - - - - - - - Multi-haem_cyto k59_1599453_1 5180.EDO01865 1.3e-19 87.8 COG1233@1|root,KOG4254@2759|Eukaryota,38GIP@33154|Opisthokonta,3NY26@4751|Fungi,3QK9T@4890|Ascomycota 4751|Fungi H Phytoene dehydrogenase - - 1.3.99.30 ko:K15745 ko00906,ko01100,ko01110,map00906,map01100,map01110 - R04787,R04798,R04800,R07518,R09692 RC01214,RC02605 ko00000,ko00001,ko01000 - - - Amino_oxidase k59_1712407_1 1123368.AUIS01000006_gene559 7.19e-44 149.0 COG1238@1|root,COG1238@2|Bacteria,1MWED@1224|Proteobacteria,1RPT7@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Membrane Z012_09465 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - - - - - - - - - - SNARE_assoc k59_1712407_2 349521.HCH_01876 1.25e-09 61.6 COG1388@1|root,COG4942@1|root,COG1388@2|Bacteria,COG4942@2|Bacteria,1RD24@1224|Proteobacteria,1RR11@1236|Gammaproteobacteria,1XJ9X@135619|Oceanospirillales 135619|Oceanospirillales DM COG0739 Membrane proteins related to metalloendopeptidases nlpD - - ko:K06194 - - - - ko00000 1.A.34.1.2 - - LysM,Peptidase_M23 k59_1543361_1 365044.Pnap_3155 4.72e-36 130.0 2A8TA@1|root,30XW9@2|Bacteria,1RFF9@1224|Proteobacteria,2VRW0@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_1768998_1 436308.Nmar_1782 2.95e-116 348.0 COG1746@1|root,arCOG04249@2157|Archaea,41S76@651137|Thaumarchaeota 651137|Thaumarchaeota J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate cca - 2.7.7.72 ko:K07558 - - R09382,R09383,R09384,R09386 RC00078 ko00000,ko01000,ko03016 - - - NTP_transf_2,tRNA_NucTransf2 k59_17924_1 1397528.Q671_03650 1.08e-68 230.0 COG0557@1|root,COG0557@2|Bacteria,1MUS6@1224|Proteobacteria,1RMQE@1236|Gammaproteobacteria,1XH6K@135619|Oceanospirillales 135619|Oceanospirillales J 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs rnr - - ko:K12573 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03016,ko03019 - - - HTH_12,OB_RNB,RNB,S1 k59_525442_1 1219035.NT2_09_01550 7.29e-13 74.7 COG4774@1|root,COG4774@2|Bacteria,1NMCN@1224|Proteobacteria,2TW4E@28211|Alphaproteobacteria,2K2TV@204457|Sphingomonadales 204457|Sphingomonadales P TonB dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_525442_2 861208.AGROH133_14221 7.32e-108 314.0 COG0655@1|root,COG0655@2|Bacteria,1MW7N@1224|Proteobacteria,2TR4Z@28211|Alphaproteobacteria,4B9AC@82115|Rhizobiaceae 28211|Alphaproteobacteria S Flavodoxin wrbA - 1.6.5.2 ko:K03809 ko00130,ko01110,map00130,map01110 - R02964,R03643,R03816 RC00819 ko00000,ko00001,ko01000 - - - FMN_red k59_525442_3 1313172.YM304_41580 1.49e-81 254.0 COG0332@1|root,COG0332@2|Bacteria 2|Bacteria I beta-ketoacyl-acyl-carrier-protein synthase III activity fabH - 2.3.1.180,2.3.1.207 ko:K00648,ko:K16872 ko00061,ko01100,ko01212,map00061,map01100,map01212 M00082,M00083 R10707 RC00004,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - iIT341.HP0202 ACP_syn_III,ACP_syn_III_C k59_752015_1 1306947.ARQD01000001_gene915 3.59e-12 65.9 COG0187@1|root,COG0187@2|Bacteria,2NNSN@2323|unclassified Bacteria 2|Bacteria L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrB GO:0003674,GO:0003824,GO:0003916,GO:0003918,GO:0008094,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017111,GO:0034335,GO:0042623,GO:0061505,GO:0140097 5.99.1.3 ko:K02470 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim k59_1712416_1 645991.Sgly_1553 1.36e-70 227.0 COG0399@1|root,COG0399@2|Bacteria,1TPDH@1239|Firmicutes,24862@186801|Clostridia,25ZZI@186807|Peptococcaceae 186801|Clostridia E PFAM DegT DnrJ EryC1 StrS aminotransferase family - - 2.6.1.33 ko:K20429 - - R02773 RC00006,RC00781 ko00000,ko01000 - - - DegT_DnrJ_EryC1 k59_921599_1 485917.Phep_4225 1.06e-06 49.7 COG1092@1|root,COG1092@2|Bacteria,4NG9S@976|Bacteroidetes,1INTU@117747|Sphingobacteriia 976|Bacteroidetes J PUA domain containing protein - - 2.1.1.191 ko:K06969 - - - - ko00000,ko01000,ko03009 - - - Methyltrans_SAM k59_921599_2 929703.KE386491_gene1841 3.33e-57 184.0 COG0846@1|root,COG0846@2|Bacteria,4NE9Q@976|Bacteroidetes,47KMH@768503|Cytophagia 976|Bacteroidetes K NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form cobB - - ko:K12410 - - - - ko00000,ko01000 - - - SIR2 k59_413111_1 1318628.MARLIPOL_06964 1.96e-11 70.1 COG3103@1|root,COG3103@2|Bacteria,1MVX1@1224|Proteobacteria,1S3BH@1236|Gammaproteobacteria,468WE@72275|Alteromonadaceae 1236|Gammaproteobacteria T N-Acetylmuramoyl-L-alanine amidase - - - - - - - - - - - - AMIN k59_1035681_1 757424.Hsero_4423 1.27e-74 239.0 COG1207@1|root,COG1207@2|Bacteria,1MUPH@1224|Proteobacteria,2VH54@28216|Betaproteobacteria,472BG@75682|Oxalobacteraceae 28216|Betaproteobacteria M Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain glmU - 2.3.1.157,2.7.7.23 ko:K04042 ko00520,ko01100,ko01130,map00520,map01100,map01130 M00362 R00416,R05332 RC00002,RC00004,RC00166 ko00000,ko00001,ko00002,ko01000 - - - Hexapep,Hexapep_2,NTP_transf_3 k59_809052_1 1088721.NSU_1882 1.59e-46 162.0 COG1668@1|root,COG1668@2|Bacteria,1MWAS@1224|Proteobacteria,2TU2K@28211|Alphaproteobacteria,2K1E9@204457|Sphingomonadales 204457|Sphingomonadales CP ABC-type Na efflux pump, permease component - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_3 k59_1429783_1 1122137.AQXF01000001_gene3150 4.65e-94 299.0 COG1049@1|root,COG1049@2|Bacteria,1MVCR@1224|Proteobacteria,2TS9P@28211|Alphaproteobacteria 28211|Alphaproteobacteria C aconitate hydratase acnB - 4.2.1.3,4.2.1.99 ko:K01682 ko00020,ko00630,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00173 R01324,R01325,R01900,R04425 RC00497,RC00498,RC00618,RC01153 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase,Aconitase_2_N,Aconitase_B_N k59_695587_1 1121935.AQXX01000083_gene42 1.39e-44 164.0 COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,1RNBG@1236|Gammaproteobacteria,1XI69@135619|Oceanospirillales 135619|Oceanospirillales L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity polA - 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1 k59_865962_1 1469245.JFBG01000011_gene820 1.35e-64 207.0 COG0686@1|root,COG0686@2|Bacteria,1QTX1@1224|Proteobacteria,1T1JB@1236|Gammaproteobacteria,1WXVZ@135613|Chromatiales 135613|Chromatiales C Belongs to the AlaDH PNT family - - 1.4.1.1 ko:K00259 ko00250,ko00430,ko01100,map00250,map00430,map01100 - R00396 RC00008 ko00000,ko00001,ko01000 - - - AlaDh_PNT_C,AlaDh_PNT_N k59_130886_1 1229909.NSED_00700 9.76e-88 268.0 COG2133@1|root,arCOG02796@2157|Archaea,41S7F@651137|Thaumarchaeota 651137|Thaumarchaeota G Glucose sorbosone - - - - - - - - - - - - GSDH k59_1599492_1 479432.Sros_2550 0.000134 48.5 COG1680@1|root,COG1680@2|Bacteria,2I1Q1@201174|Actinobacteria,4EP5Z@85012|Streptosporangiales 201174|Actinobacteria V Beta-lactamase - - - - - - - - - - - - Beta-lactamase k59_1265188_1 1122137.AQXF01000004_gene1612 1.8e-51 169.0 COG0476@1|root,COG0476@2|Bacteria,1MW7H@1224|Proteobacteria,2TRWY@28211|Alphaproteobacteria 28211|Alphaproteobacteria H Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family moeB - 2.7.7.80 ko:K21029 ko04122,map04122 - R07459 RC00043 ko00000,ko00001,ko01000 - - - ThiF k59_1265188_2 1122137.AQXF01000004_gene1613 5.72e-29 108.0 COG2044@1|root,COG2044@2|Bacteria,1NMCT@1224|Proteobacteria,2UN6Z@28211|Alphaproteobacteria 28211|Alphaproteobacteria S DsrE/DsrF-like family - - - - - - - - - - - - DrsE k59_474581_1 1198452.Jab_2c14860 9.41e-16 87.8 COG1629@1|root,COG4771@2|Bacteria,1MVFB@1224|Proteobacteria 1224|Proteobacteria P COG1629 Outer membrane receptor proteins, mostly Fe transport - - - - - - - - - - - - Plug,TonB_dep_Rec k59_192845_1 1415778.JQMM01000001_gene1396 8.13e-79 258.0 COG1251@1|root,COG1251@2|Bacteria,1MW58@1224|Proteobacteria,1RNGY@1236|Gammaproteobacteria,1J7Y2@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C BFD-like [2Fe-2S] binding domain - - 1.7.1.15 ko:K00362 ko00910,ko01120,map00910,map01120 M00530 R00787 RC00176 ko00000,ko00001,ko00002,ko01000 - - - Fer2_BFD,Pyr_redox_2 k59_364052_1 1121472.AQWN01000002_gene2041 5.32e-46 155.0 COG0088@1|root,COG0088@2|Bacteria,1TPGW@1239|Firmicutes,248SY@186801|Clostridia,26186@186807|Peptococcaceae 186801|Clostridia J Forms part of the polypeptide exit tunnel rplD - - ko:K02926 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L4 k59_364052_2 1343158.SACS_0026 8.48e-05 43.9 COG0087@1|root,COG0087@2|Bacteria,1MUST@1224|Proteobacteria,2TRHB@28211|Alphaproteobacteria,2JPA8@204441|Rhodospirillales 204441|Rhodospirillales J One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit rplC - - ko:K02906 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L3 k59_872529_1 234267.Acid_2289 1.99e-72 244.0 COG2303@1|root,COG4993@1|root,COG2303@2|Bacteria,COG4993@2|Bacteria 2|Bacteria G Dehydrogenase - - 1.1.5.2,1.1.5.9 ko:K00117,ko:K19813 ko00030,ko01100,ko01110,ko01130,map00030,map01100,map01110,map01130 - R00305,R06620 RC00066 ko00000,ko00001,ko01000 - - - GMC_oxred_C,GMC_oxred_N,PQQ,PQQ_2 k59_192849_1 1096930.L284_05330 2.08e-72 243.0 COG1520@1|root,COG1520@2|Bacteria,1P31B@1224|Proteobacteria,2U4EC@28211|Alphaproteobacteria,2K25M@204457|Sphingomonadales 204457|Sphingomonadales S Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane - - - - - - - - - - - - - k59_249629_1 641526.ADIWIN_2972 1.33e-121 370.0 COG2217@1|root,COG2217@2|Bacteria,4NEI1@976|Bacteroidetes,1HXJI@117743|Flavobacteriia 976|Bacteroidetes P cation transport ATPase ccoI - 3.6.3.4,3.6.3.54 ko:K01533,ko:K17686 ko01524,ko04016,map01524,map04016 - R00086 RC00002 ko00000,ko00001,ko01000 3.A.3.5 - - ATPase-cat_bd,E1-E2_ATPase,HMA,Hydrolase k59_1662030_1 350688.Clos_2797 3.55e-58 197.0 COG0305@1|root,COG0305@2|Bacteria,1TPCT@1239|Firmicutes,247W3@186801|Clostridia,36DTR@31979|Clostridiaceae 186801|Clostridia L Participates in initiation and elongation during chromosome replication dnaB - 3.6.4.12 ko:K02314 ko03030,ko04112,map03030,map04112 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB,DnaB_C k59_192851_1 1217656.F964_03840 0.000194 48.1 COG2207@1|root,COG2207@2|Bacteria,1NQQ4@1224|Proteobacteria,1SK2X@1236|Gammaproteobacteria,3NT3B@468|Moraxellaceae 1236|Gammaproteobacteria K helix_turn_helix, arabinose operon control protein - - - - - - - - - - - - AraC_binding,HTH_18 k59_926804_1 1117315.AHCA01000017_gene1591 3.28e-148 434.0 COG1457@1|root,COG1457@2|Bacteria,1NGY9@1224|Proteobacteria,1RNK5@1236|Gammaproteobacteria,2Q050@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria F COG1457 Purine-cytosine permease and related proteins - - - - - - - - - - - - - k59_1380593_1 1121028.ARQE01000004_gene1488 2.39e-116 349.0 COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2TQR1@28211|Alphaproteobacteria,2PKK1@255475|Aurantimonadaceae 28211|Alphaproteobacteria C Aldehyde dehydrogenase family - - 1.2.1.3 ko:K00128 ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130 M00135 R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146 RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_588876_1 439497.RR11_883 1.1e-52 179.0 COG0765@1|root,COG0765@2|Bacteria,1MWF0@1224|Proteobacteria,2TRCT@28211|Alphaproteobacteria,4NBPQ@97050|Ruegeria 28211|Alphaproteobacteria P Amino acid ABC transporter, permease protein, 3-TM region, His Glu Gln Arg opine yxeN - - ko:K02029 - M00236 - - ko00000,ko00002,ko02000 3.A.1.3 - - BPD_transp_1 k59_1042295_1 316407.4062787 6.96e-159 451.0 COG0012@1|root,COG0012@2|Bacteria,1MVM4@1224|Proteobacteria,1RMBI@1236|Gammaproteobacteria,3XNGE@561|Escherichia 1236|Gammaproteobacteria J ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner ychF GO:0003674,GO:0003824,GO:0004857,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006950,GO:0006979,GO:0008150,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030234,GO:0043021,GO:0043022,GO:0043023,GO:0043086,GO:0044092,GO:0044424,GO:0044464,GO:0044877,GO:0050790,GO:0050896,GO:0065007,GO:0065009,GO:0098772 - ko:K06942 - - - - ko00000,ko03009 - - - MMR_HSR1,YchF-GTPase_C k59_530272_1 713587.THITH_10010 8.5e-41 143.0 COG0121@1|root,COG0121@2|Bacteria,1PX9X@1224|Proteobacteria,1SBGN@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Glutamine amidotransferase egtC - - - - - - - - - - - GATase_4 k59_530272_2 765913.ThidrDRAFT_3408 4.26e-29 112.0 COG0078@1|root,COG0078@2|Bacteria,1MUFM@1224|Proteobacteria,1RQ59@1236|Gammaproteobacteria,1WWPW@135613|Chromatiales 135613|Chromatiales E Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline argF - 2.1.3.3 ko:K00611 ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230 M00029,M00844 R01398 RC00096 ko00000,ko00001,ko00002,ko01000 - - - OTCace,OTCace_N k59_588884_1 472759.Nhal_0036 3.65e-105 324.0 COG0358@1|root,COG0358@2|Bacteria,1MUHC@1224|Proteobacteria,1RMGA@1236|Gammaproteobacteria,1WX02@135613|Chromatiales 135613|Chromatiales L RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication dnaG - - ko:K02316 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB_bind,DnaG_DnaB_bind,Toprim_2,Toprim_4,Toprim_N,zf-CHC2 k59_1380608_2 1037409.BJ6T_31660 1.18e-56 185.0 COG4566@1|root,COG4566@2|Bacteria,1N6WR@1224|Proteobacteria,2TRJB@28211|Alphaproteobacteria,3K5X9@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria T helix_turn_helix, Lux Regulon - - - - - - - - - - - - GerE,Response_reg k59_1096415_1 697282.Mettu_1061 2.33e-55 196.0 COG1201@1|root,COG1201@2|Bacteria,1MUSW@1224|Proteobacteria,1RSNV@1236|Gammaproteobacteria,1XDT8@135618|Methylococcales 135618|Methylococcales L DEAD DEAH box - - - ko:K03724 - - - - ko00000,ko01000,ko03400 - - - DEAD,DEAD_assoc,Helicase_C k59_1662058_1 1207063.P24_13673 1.55e-102 310.0 COG1053@1|root,COG1053@2|Bacteria,1MX5A@1224|Proteobacteria,2TV7T@28211|Alphaproteobacteria,2JQSB@204441|Rhodospirillales 204441|Rhodospirillales C FAD dependent oxidoreductase - - - - - - - - - - - - FAD_binding_2 k59_474615_1 1484460.JSWG01000009_gene216 4.63e-34 121.0 COG0712@1|root,COG0712@2|Bacteria,4NSNF@976|Bacteroidetes,1I28E@117743|Flavobacteriia 976|Bacteroidetes C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation atpH - - ko:K02113 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - OSCP k59_474615_2 1197477.IA57_05095 3.22e-81 255.0 COG0056@1|root,COG0056@2|Bacteria,4NFZW@976|Bacteroidetes,1HXGV@117743|Flavobacteriia 976|Bacteroidetes C Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit atpA - 3.6.3.14 ko:K02111 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - - ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N k59_813885_1 991.IW20_14410 1.22e-09 57.8 COG0055@1|root,COG0055@2|Bacteria,4NF1Q@976|Bacteroidetes,1HWM2@117743|Flavobacteriia,2NSI1@237|Flavobacterium 976|Bacteroidetes C Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits atpD - 3.6.3.14 ko:K02112 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - - ATP-synt_ab,ATP-synt_ab_N k59_813885_2 555500.I215_00695 1.77e-38 130.0 COG0355@1|root,COG0355@2|Bacteria,4NUYG@976|Bacteroidetes,1I5R2@117743|Flavobacteriia 976|Bacteroidetes C COG0355 F0F1-type ATP synthase epsilon subunit (mitochondrial delta subunit) atpC - - ko:K02114 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt_DE_N k59_531079_1 930166.CD58_06125 1.57e-105 336.0 COG0587@1|root,COG0587@2|Bacteria,1MUIF@1224|Proteobacteria,1RP0K@1236|Gammaproteobacteria 1236|Gammaproteobacteria L DNA polymerase dnaE GO:0003674,GO:0003824,GO:0003887,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032991,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0042575,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044776,GO:0046483,GO:0061695,GO:0071704,GO:0071897,GO:0090304,GO:0140097,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234 2.7.7.7 ko:K02337 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon k59_1154415_1 398580.Dshi_0845 2.29e-62 210.0 COG0534@1|root,COG0534@2|Bacteria,1MV6B@1224|Proteobacteria,2TSKZ@28211|Alphaproteobacteria 28211|Alphaproteobacteria V COG0534 Na -driven multidrug efflux pump dinF GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K03327 - - - - ko00000,ko02000 2.A.66.1 - - MatE k59_82947_1 436308.Nmar_1488 5.87e-43 154.0 COG0072@1|root,arCOG00412@2157|Archaea,41S8M@651137|Thaumarchaeota 651137|Thaumarchaeota J phenylalanyl-tRNA synthetase, beta subunit - - 6.1.1.20 ko:K01890 ko00970,map00970 M00359,M00360 R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - B3_4,B5 k59_1720306_1 1304880.JAGB01000002_gene2138 1.46e-181 521.0 COG0527@1|root,COG0527@2|Bacteria,1TPQJ@1239|Firmicutes,24811@186801|Clostridia 186801|Clostridia E Belongs to the aspartokinase family thrA - 2.7.2.4 ko:K00928 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00017,M00018,M00033,M00525,M00526,M00527 R00480 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase,ACT,ACT_7 k59_1323384_1 1429046.RR21198_4299 5.24e-10 65.5 COG0726@1|root,COG0726@2|Bacteria,2IC87@201174|Actinobacteria 201174|Actinobacteria G Polysaccharide deacetylase - - - - - - - - - - - - Polysacc_deac_1 k59_1211784_1 383381.EH30_08090 1.84e-61 211.0 COG1506@1|root,COG1506@2|Bacteria,1MUJ3@1224|Proteobacteria,2TUZZ@28211|Alphaproteobacteria,2JZXS@204457|Sphingomonadales 204457|Sphingomonadales E COG1506 Dipeptidyl aminopeptidases acylaminoacyl-peptidases - - - - - - - - - - - - Peptidase_S9 k59_1774338_1 977880.RALTA_B1898 4.24e-65 210.0 COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2VP82@28216|Betaproteobacteria,1KD4A@119060|Burkholderiaceae 28216|Betaproteobacteria S Tripartite tricarboxylate transporter family receptor - - - - - - - - - - - - TctC k59_927668_1 706587.Desti_5385 2.61e-60 206.0 COG2204@1|root,COG3850@1|root,COG2204@2|Bacteria,COG3850@2|Bacteria,1MU0N@1224|Proteobacteria,43BK2@68525|delta/epsilon subdivisions,2X6XX@28221|Deltaproteobacteria 28221|Deltaproteobacteria T Sigma-54 factor interaction domain-containing protein - - - ko:K02481,ko:K07712,ko:K07713 ko02020,map02020 M00497,M00499 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,PAS_4,Response_reg,Sigma54_activat k59_1043489_1 1121413.JMKT01000015_gene282 2.91e-54 189.0 COG3420@1|root,COG3420@2|Bacteria,1R629@1224|Proteobacteria 1224|Proteobacteria P alginic acid biosynthetic process - - - - - - - - - - - - - k59_927671_1 1122137.AQXF01000001_gene3155 2.44e-65 219.0 COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,2TR6Q@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Belongs to the DEAD box helicase family rhlE - 3.6.4.13 ko:K11927 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - DEAD,Helicase_C k59_250822_1 472759.Nhal_1956 5.78e-41 146.0 COG2187@1|root,COG2187@2|Bacteria,1R98V@1224|Proteobacteria,1T025@1236|Gammaproteobacteria 1236|Gammaproteobacteria S AAA domain - - - - - - - - - - - - - k59_25770_1 1202962.KB907151_gene927 1.54e-40 152.0 COG1574@1|root,COG3126@1|root,COG1574@2|Bacteria,COG3126@2|Bacteria,1MWP2@1224|Proteobacteria,1RNB7@1236|Gammaproteobacteria 1236|Gammaproteobacteria S metal-dependent hydrolase with the TIM-barrel fold - - - - - - - - - - - - Amidohydro_3,YscW k59_1154430_2 930169.B5T_01314 2.4e-42 146.0 2DZH7@1|root,32VAP@2|Bacteria,1N6FC@1224|Proteobacteria,1SABS@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - TerB k59_1266196_1 231434.JQJH01000003_gene449 1.3e-86 277.0 COG3119@1|root,COG3119@2|Bacteria,1MV92@1224|Proteobacteria,2TTXG@28211|Alphaproteobacteria 28211|Alphaproteobacteria P Arylsulfatase - - - - - - - - - - - - Sulfatase k59_873749_1 745014.OMB55_00001830 2.9e-89 268.0 COG0090@1|root,COG0090@2|Bacteria,1MVTD@1224|Proteobacteria,1RMGR@1236|Gammaproteobacteria,1J4FI@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity rplB GO:0000027,GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046872,GO:0046914,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02886 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L2,Ribosomal_L2_C k59_873749_2 566466.NOR53_218 2.37e-54 170.0 COG0185@1|root,COG0185@2|Bacteria,1RGYX@1224|Proteobacteria,1S5VT@1236|Gammaproteobacteria,1J6B1@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA rpsS GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02965 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S19 k59_873749_3 1415778.JQMM01000001_gene386 3.68e-61 189.0 COG0091@1|root,COG0091@2|Bacteria,1RH0W@1224|Proteobacteria,1S5XT@1236|Gammaproteobacteria,1J668@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome rplV GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005844,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042788,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02890 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L22 k59_873749_4 203122.Sde_0966 1.01e-16 76.6 COG0092@1|root,COG0092@2|Bacteria,1MUAI@1224|Proteobacteria,1RN0P@1236|Gammaproteobacteria,46670@72275|Alteromonadaceae 1236|Gammaproteobacteria J Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation rpsC GO:0000028,GO:0002181,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02982 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - KH_2,Ribosomal_S3_C k59_250834_1 1131553.JIBI01000053_gene38 1.68e-76 241.0 COG0156@1|root,COG0156@2|Bacteria,1MVVH@1224|Proteobacteria,2VH25@28216|Betaproteobacteria,372XJ@32003|Nitrosomonadales 28216|Betaproteobacteria H Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide bioF - 2.3.1.47 ko:K00652 ko00780,ko01100,map00780,map01100 M00123,M00573,M00577 R03210,R10124 RC00004,RC00039,RC02725 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 k59_1097408_2 391165.GbCGDNIH1_0959 5.31e-53 171.0 COG0347@1|root,COG0347@2|Bacteria,1RGWK@1224|Proteobacteria,2U73Z@28211|Alphaproteobacteria,2JS4R@204441|Rhodospirillales 204441|Rhodospirillales K Belongs to the P(II) protein family glnB GO:0003674,GO:0006808,GO:0008150,GO:0030234,GO:0050789,GO:0050790,GO:0065007,GO:0065009,GO:0098772 - ko:K04751 ko02020,map02020 - - - ko00000,ko00001 - - - P-II k59_873761_1 1096930.L284_15635 1.18e-81 272.0 COG2911@1|root,COG2911@2|Bacteria,1MUVD@1224|Proteobacteria,2TR45@28211|Alphaproteobacteria,2K0C4@204457|Sphingomonadales 204457|Sphingomonadales S protein conserved in bacteria - - - ko:K09800 - - - - ko00000,ko02000 - - - TamB k59_757907_2 671143.DAMO_0416 4.47e-37 142.0 COG0784@1|root,COG3829@1|root,COG4191@1|root,COG0784@2|Bacteria,COG3829@2|Bacteria,COG4191@2|Bacteria,2NS4C@2323|unclassified Bacteria 2|Bacteria T Histidine kinase - - - - - - - - - - - - CBS,GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg k59_531112_1 671065.MetMK1DRAFT_00019750 2.3e-06 50.8 COG0517@1|root,arCOG00606@2157|Archaea,2XQQK@28889|Crenarchaeota 28889|Crenarchaeota S PFAM CBS domain containing protein - - - - - - - - - - - - CBS k59_703393_1 236814.IX39_09125 1.29e-26 102.0 COG1595@1|root,COG1595@2|Bacteria,4NN4K@976|Bacteroidetes,1I0T3@117743|Flavobacteriia,3ZNVA@59732|Chryseobacterium 976|Bacteroidetes K Belongs to the sigma-70 factor family. ECF subfamily fecI - - - - - - - - - - - Sigma70_r2,Sigma70_r4,Sigma70_r4_2 k59_703393_2 694427.Palpr_0018 1.1e-17 79.7 2E5Q2@1|root,330EP@2|Bacteria,4NUMS@976|Bacteroidetes,2FUW0@200643|Bacteroidia,22YU0@171551|Porphyromonadaceae 976|Bacteroidetes - - - - - - - - - - - - - - - k59_1381864_1 1229909.NSED_09175 1.93e-58 186.0 arCOG10600@1|root,arCOG10600@2157|Archaea,41T8K@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_25812_1 1117647.M5M_01823 5.78e-59 188.0 COG0720@1|root,COG0720@2|Bacteria,1N10D@1224|Proteobacteria,1SBJZ@1236|Gammaproteobacteria,1J65G@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H COG0720 6-pyruvoyl-tetrahydropterin synthase - - 4.1.2.50,4.2.3.12 ko:K01737 ko00790,ko01100,map00790,map01100 M00842,M00843 R04286,R09959 RC01117,RC02846,RC02847 ko00000,ko00001,ko00002,ko01000,ko03016 - - - PTPS k59_1381871_1 78898.MVEG_04711T0 1.53e-25 110.0 COG1109@1|root,KOG1220@2759|Eukaryota,38FHZ@33154|Opisthokonta,3NXBY@4751|Fungi,1GSJA@112252|Fungi incertae sedis 4751|Fungi G Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III - GO:0003674,GO:0003824,GO:0004614,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006139,GO:0006148,GO:0006152,GO:0006166,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008617,GO:0008973,GO:0009056,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009164,GO:0009987,GO:0016853,GO:0016866,GO:0016868,GO:0018130,GO:0019318,GO:0019438,GO:0019439,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0042278,GO:0042451,GO:0042454,GO:0042455,GO:0043094,GO:0043101,GO:0043174,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046102,GO:0046115,GO:0046128,GO:0046129,GO:0046130,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0072523,GO:1901068,GO:1901069,GO:1901135,GO:1901136,GO:1901137,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901657,GO:1901658,GO:1901659 5.4.2.2,5.4.2.7 ko:K01835,ko:K15779 ko00010,ko00030,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130 M00549 R00959,R01057,R02749,R08639 RC00408 ko00000,ko00001,ko00002,ko01000 - - - PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV k59_250862_2 455436.DS989810_gene303 1.98e-80 253.0 COG4225@1|root,COG4225@2|Bacteria,1NSJK@1224|Proteobacteria,1T1DP@1236|Gammaproteobacteria,466IH@72275|Alteromonadaceae 1236|Gammaproteobacteria S Glycosyl Hydrolase Family 88 - - - - - - - - - - - - Glyco_hydro_88 k59_138558_1 1125973.JNLC01000011_gene548 2.65e-140 411.0 COG1053@1|root,COG1053@2|Bacteria,1MX5A@1224|Proteobacteria,2TV7T@28211|Alphaproteobacteria,3JQYS@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria C FAD dependent oxidoreductase cobZ - - ko:K13796 - - - - ko00000 - - - FAD_binding_2 k59_250867_1 1382306.JNIM01000001_gene1827 4.02e-22 100.0 COG4867@1|root,COG4867@2|Bacteria,2G8A6@200795|Chloroflexi 200795|Chloroflexi S von Willebrand factor (vWF) type A domain - - - - - - - - - - - - - k59_475535_1 693661.Arcve_0930 7.34e-26 103.0 COG1985@1|root,arCOG01484@2157|Archaea,2XU47@28890|Euryarchaeota,246Y1@183980|Archaeoglobi 183980|Archaeoglobi H RibD C-terminal domain - - 1.1.1.302 ko:K14654 ko00740,ko01100,map00740,map01100 - R09375,R09376 RC00933 ko00000,ko00001,ko01000 - - - RibD_C k59_193789_1 118166.JH976537_gene1710 1.15e-44 162.0 COG1459@1|root,COG1459@2|Bacteria,1G164@1117|Cyanobacteria,1H8FS@1150|Oscillatoriales 1117|Cyanobacteria U Bacterial type II secretion system protein F domain pilC - - ko:K02653 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSF k59_365433_1 1088721.NSU_3676 3.87e-82 256.0 COG0457@1|root,COG0457@2|Bacteria,1QZNZ@1224|Proteobacteria,2TYAT@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Protein of unknown function (DUF560) - - - - - - - - - - - - DUF560 k59_1211859_1 9778.XP_004381822.1 9.09e-20 88.2 COG1335@1|root,KOG4044@2759|Eukaryota,39X6I@33154|Opisthokonta,3BIK9@33208|Metazoa,3CZM3@33213|Bilateria,489ZR@7711|Chordata,48YJV@7742|Vertebrata,3J1QA@40674|Mammalia,34SQ4@311790|Afrotheria 33208|Metazoa Q Isochorismatase domain-containing protein 2, mitochondrial ISOC2 GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0008150,GO:0031647,GO:0031648,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044464,GO:0065007,GO:0065008 - - - - - - - - - - Isochorismatase k59_1663074_1 999413.HMPREF1094_01013 0.0006 48.5 COG0642@1|root,COG2205@2|Bacteria,1V10X@1239|Firmicutes,3VPM0@526524|Erysipelotrichia 526524|Erysipelotrichia T ATPase histidine kinase DNA gyrase B HSP90 domain protein - - - - - - - - - - - - HATPase_c,HisKA k59_1615354_1 1209072.ALBT01000023_gene4016 2.99e-19 95.5 28IAG@1|root,2Z8D2@2|Bacteria,1P5EH@1224|Proteobacteria,1RYCA@1236|Gammaproteobacteria,1FI1T@10|Cellvibrio 1236|Gammaproteobacteria - - - - - - - - - - - - - - DUF4129 k59_713998_1 1229909.NSED_03045 3.72e-234 655.0 COG1243@1|root,arCOG01361@2157|Archaea,41S9N@651137|Thaumarchaeota 651137|Thaumarchaeota K Histone acetyltransferase - - 2.3.1.48 ko:K07739 - - - - ko00000,ko01000,ko03016,ko03036 - - - Acetyltransf_1,Radical_SAM,Radical_SAM_C k59_1505720_1 379066.GAU_2161 1.49e-46 160.0 COG2177@1|root,COG2177@2|Bacteria,1ZTDR@142182|Gemmatimonadetes 142182|Gemmatimonadetes D Part of the ABC transporter FtsEX involved in - - - ko:K09811 ko02010,map02010 M00256 - - ko00000,ko00001,ko00002,ko02000,ko03036 3.A.1.140 - - - k59_1164312_1 314287.GB2207_09021 1.93e-50 173.0 COG0500@1|root,COG0640@1|root,COG0500@2|Bacteria,COG0640@2|Bacteria,1NFSV@1224|Proteobacteria,1RQT6@1236|Gammaproteobacteria,1J51S@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria KQ helix_turn_helix, Arsenical Resistance Operon Repressor - - - - - - - - - - - - HTH_20,HTH_5,Methyltransf_11,Methyltransf_23,Methyltransf_31 k59_1392695_1 436308.Nmar_1482 1.88e-126 380.0 COG1048@1|root,arCOG01697@2157|Archaea,41SE6@651137|Thaumarchaeota 651137|Thaumarchaeota C aconitate hydratase - - 4.2.1.3 ko:K01681 ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00173,M00740 R01324,R01325,R01900 RC00497,RC00498,RC00618 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase,Aconitase_C k59_1105348_1 1280949.HAD_06375 6.16e-50 165.0 28NHY@1|root,2ZBJH@2|Bacteria,1RAWQ@1224|Proteobacteria,2TYJH@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Protein of unknown function (DUF1217) - - - - - - - - - - - - DUF1217 k59_1105348_2 1280949.HAD_06370 1.17e-48 157.0 COG5443@1|root,COG5443@2|Bacteria,1Q14Y@1224|Proteobacteria,2V91R@28211|Alphaproteobacteria,43ZWB@69657|Hyphomonadaceae 28211|Alphaproteobacteria N Flagellar protein FlbT - - - - - - - - - - - - FlbT k59_261360_1 1333998.M2A_0383 6.04e-103 308.0 COG2175@1|root,COG2175@2|Bacteria,1Q0C7@1224|Proteobacteria,2TRGF@28211|Alphaproteobacteria,4BS4G@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria Q Taurine catabolism dioxygenase TauD, TfdA family - - - - - - - - - - - - TauD k59_36431_1 314287.GB2207_10813 3.24e-58 187.0 COG0806@1|root,COG0806@2|Bacteria,1MWQR@1224|Proteobacteria,1RNJ2@1236|Gammaproteobacteria,1J6R6@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes rimM GO:0000028,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016072,GO:0022607,GO:0022613,GO:0022618,GO:0030490,GO:0034470,GO:0034622,GO:0034641,GO:0034660,GO:0042254,GO:0042255,GO:0042274,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:1901360 - ko:K02860 - - - - ko00000,ko03009 - - - PRC,RimM k59_319567_1 517722.AEUE01000002_gene2089 1.68e-87 263.0 COG1192@1|root,COG1192@2|Bacteria,1MV43@1224|Proteobacteria,2TSWH@28211|Alphaproteobacteria,2K02Z@204457|Sphingomonadales 204457|Sphingomonadales D Chromosome partitioning - - - ko:K03496 - - - - ko00000,ko03036,ko04812 - - - AAA_31 k59_1563064_1 404380.Gbem_1761 1.26e-42 163.0 COG0308@1|root,COG0308@2|Bacteria,1PEPK@1224|Proteobacteria,42NJ8@68525|delta/epsilon subdivisions,2WM57@28221|Deltaproteobacteria,43TCR@69541|Desulfuromonadales 28221|Deltaproteobacteria E Peptidase family M1 domain - - - - - - - - - - - iAF987.Gmet_0348 Peptidase_M1 k59_1164319_2 436308.Nmar_0635 8.77e-112 329.0 COG2084@1|root,arCOG00247@2157|Archaea,41SI2@651137|Thaumarchaeota 651137|Thaumarchaeota I NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase - - 1.1.1.31 ko:K00020 ko00280,ko01100,map00280,map01100 - R05066 RC00099 ko00000,ko00001,ko01000 - - - NAD_binding_11,NAD_binding_2 k59_1505732_1 555793.WSK_0153 1.44e-79 251.0 COG3182@1|root,COG3182@2|Bacteria,1MX8C@1224|Proteobacteria,2TSQ9@28211|Alphaproteobacteria,2K2NI@204457|Sphingomonadales 204457|Sphingomonadales S PepSY-associated TM region - - - - - - - - - - - - PepSY_TM k59_991036_1 517418.Ctha_1642 1.71e-25 104.0 COG1723@1|root,COG1723@2|Bacteria 2|Bacteria S PFAM Uncharacterised ACR, YagE family COG1723 yagE - - - - - - - - - - - DUF155 k59_991040_1 1174528.JH992898_gene4658 1.08e-58 191.0 COG3385@1|root,COG3385@2|Bacteria,1G4GS@1117|Cyanobacteria 1117|Cyanobacteria L transposase activity - - - - - - - - - - - - DDE_5 k59_824111_1 756272.Plabr_3017 3.29e-68 210.0 COG0636@1|root,COG0636@2|Bacteria 2|Bacteria C ATP hydrolysis coupled proton transport atpE GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0042802,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0044769,GO:0045259,GO:0045263,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - ko:K02110,ko:K02124 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157,M00159 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1,3.A.2.2,3.A.2.3 - - ATP-synt_C k59_824111_2 756272.Plabr_3018 4.63e-36 135.0 COG1269@1|root,COG1269@2|Bacteria,2J3SY@203682|Planctomycetes 203682|Planctomycetes U V-type ATPase 116kDa subunit family - - - ko:K02123 ko00190,ko01100,map00190,map01100 M00159 - - ko00000,ko00001,ko00002 3.A.2.2,3.A.2.3 - - V_ATPase_I k59_36454_1 1122137.AQXF01000003_gene2240 1.35e-115 343.0 COG2124@1|root,COG2124@2|Bacteria,1MV75@1224|Proteobacteria,2TSV7@28211|Alphaproteobacteria 28211|Alphaproteobacteria Q cytochrome P450 MA20_23450 - - - - - - - - - - - p450 k59_714026_1 765912.Thimo_3423 2.19e-62 214.0 COG2010@1|root,COG2010@2|Bacteria,1R58S@1224|Proteobacteria,1RZ9B@1236|Gammaproteobacteria,1WXG4@135613|Chromatiales 135613|Chromatiales C Cytochrome c - - - - - - - - - - - - - k59_1505751_1 1122197.ATWI01000010_gene1004 1.04e-53 184.0 COG1233@1|root,COG1233@2|Bacteria,1MV2R@1224|Proteobacteria,1RMGJ@1236|Gammaproteobacteria,46C30@72275|Alteromonadaceae 1236|Gammaproteobacteria Q Flavin containing amine oxidoreductase - - 1.3.99.23 ko:K09516 ko00830,map00830 - R07163 RC01835 ko00000,ko00001,ko01000 - - - Amino_oxidase,FAD_binding_6,NAD_binding_1,NAD_binding_8 k59_483022_1 396588.Tgr7_0458 1.19e-31 127.0 COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,1RR36@1236|Gammaproteobacteria,1WYS8@135613|Chromatiales 135613|Chromatiales KLT serine threonine protein kinase - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - HAMP,HEAT_2,Pkinase,sCache_3_2 k59_991051_1 1121434.AULY01000006_gene929 3.75e-48 174.0 COG0668@1|root,COG0668@2|Bacteria,1MXD2@1224|Proteobacteria,43C4Y@68525|delta/epsilon subdivisions,2X7FA@28221|Deltaproteobacteria 28221|Deltaproteobacteria M Mechanosensitive ion channel - - - - - - - - - - - - MS_channel k59_146416_1 1121861.KB899913_gene2281 2.12e-54 179.0 COG0760@1|root,COG0760@2|Bacteria,1RDD3@1224|Proteobacteria,2U3I3@28211|Alphaproteobacteria,2JS8D@204441|Rhodospirillales 204441|Rhodospirillales O PPIC-type PPIASE domain - - 5.2.1.8 ko:K03769 - - - - ko00000,ko01000,ko03110 - - - Rotamase k59_884523_1 188626.HMPREF0321_2683 6.72e-34 134.0 COG2232@1|root,COG2232@2|Bacteria,2IDDC@201174|Actinobacteria,1ZWHS@145357|Dermacoccaceae 201174|Actinobacteria S ATP-grasp domain - - - - - - - - - - - - - k59_261399_1 243233.MCA0770 6.97e-28 112.0 COG0493@1|root,COG1144@1|root,COG0493@2|Bacteria,COG1144@2|Bacteria,1MU2H@1224|Proteobacteria,1RMY7@1236|Gammaproteobacteria,1XE4Y@135618|Methylococcales 1236|Gammaproteobacteria C Glutamate synthase, NADH NADPH, small subunit - - 1.4.1.13,1.4.1.14 ko:K00266 ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 - R00093,R00114,R00248 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - DHODB_Fe-S_bind,Fer4,Fer4_20,NAD_binding_1,Pyr_redox_2 k59_1164353_1 1121374.KB891575_gene1191 3.01e-29 116.0 28NHW@1|root,2ZBJG@2|Bacteria,1RBJB@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_1164353_2 1122137.AQXF01000006_gene749 7.85e-41 141.0 COG2071@1|root,COG2071@2|Bacteria,1MV8E@1224|Proteobacteria,2TSU3@28211|Alphaproteobacteria 28211|Alphaproteobacteria S -glutamine - - - ko:K07010 - - - - ko00000,ko01002 - - - Peptidase_C26 k59_319614_1 1266925.JHVX01000008_gene274 1.19e-72 235.0 COG0006@1|root,COG0006@2|Bacteria,1MUZS@1224|Proteobacteria,2VHQI@28216|Betaproteobacteria,372V1@32003|Nitrosomonadales 28216|Betaproteobacteria E peptidase M24B, X-Pro dipeptidase aminopeptidase pepP - 3.4.11.9 ko:K01262 - - - - ko00000,ko01000,ko01002 - - - AMP_N,Peptidase_M24 k59_36482_1 1229909.NSED_02425 3.88e-89 271.0 COG3329@1|root,arCOG11287@2157|Archaea 2157|Archaea S Na+-dependent bicarbonate transporter superfamily - - - ko:K07086 - - - - ko00000 - - - Sbt_1 k59_1563118_1 198214.SF4109 3.46e-157 453.0 COG2194@1|root,COG2194@2|Bacteria,1MWS7@1224|Proteobacteria,1RMNG@1236|Gammaproteobacteria 1236|Gammaproteobacteria S membrane-associated metal-dependent hydrolase eptA GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016740,GO:0016772,GO:0016776,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044464,GO:0046401,GO:0071704,GO:0071944,GO:1901135,GO:1901137,GO:1901576,GO:1903509 2.7.8.42,2.7.8.43 ko:K03760,ko:K12975,ko:K19353 ko00540,ko01503,map00540,map01503 M00722,M00723 R11204,R11205,R11555,R11556,R11557 RC00002,RC00017,RC00428 ko00000,ko00001,ko00002,ko01000,ko01005 - - iSSON_1240.SSON_3844 DUF1705,Sulfatase k59_714053_1 525244.HMPREF0023_1357 1.42e-71 224.0 COG1117@1|root,COG1117@2|Bacteria,1MU16@1224|Proteobacteria,1RNUF@1236|Gammaproteobacteria,3NIWW@468|Moraxellaceae 1236|Gammaproteobacteria P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system pstB - 3.6.3.27 ko:K02036 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.7 - - ABC_tran k59_146431_1 1454004.AW11_00446 2.36e-29 116.0 COG0457@1|root,COG0457@2|Bacteria,1MYB8@1224|Proteobacteria,2VI6C@28216|Betaproteobacteria,1KQJG@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria M SMART Tetratricopeptide domain protein - - - - - - - - - - - - TPR_16,TPR_19,TPR_8 k59_146431_2 1123393.KB891330_gene738 6.84e-15 73.2 COG3017@1|root,COG3017@2|Bacteria,1N02T@1224|Proteobacteria,2VUIR@28216|Betaproteobacteria,1KS6V@119069|Hydrogenophilales 119069|Hydrogenophilales M Outer membrane lipoprotein LolB - - - - - - - - - - - - LolB k59_1105393_1 330214.NIDE3643 1.34e-46 155.0 COG0221@1|root,COG0221@2|Bacteria,3J184@40117|Nitrospirae 40117|Nitrospirae C Inorganic pyrophosphatase ppa - 3.6.1.1 ko:K01507 ko00190,map00190 - - - ko00000,ko00001,ko01000 - - - Pyrophosphatase k59_1105393_2 365528.KB891219_gene1058 7.08e-38 142.0 COG0364@1|root,COG0364@2|Bacteria,2GISI@201174|Actinobacteria,4ES6Y@85013|Frankiales 201174|Actinobacteria G Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone zwf GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 1.1.1.363,1.1.1.49 ko:K00036 ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230 M00004,M00006,M00008 R00835,R02736,R10907 RC00001,RC00066 ko00000,ko00001,ko00002,ko01000,ko04147 - - - G6PD_C,G6PD_N k59_1505780_1 392499.Swit_0223 8.3e-32 126.0 COG5276@1|root,COG5276@2|Bacteria,1R66X@1224|Proteobacteria,2U4DF@28211|Alphaproteobacteria,2K18I@204457|Sphingomonadales 204457|Sphingomonadales S LVIVD repeat - - - - - - - - - - - - LVIVD k59_600984_1 595593.JREV01000008_gene2771 9.7e-10 58.5 COG2008@1|root,COG2008@2|Bacteria,2GJ0V@201174|Actinobacteria,1W8M0@1268|Micrococcaceae 201174|Actinobacteria E Threonine aldolase ltaE - 4.1.2.48 ko:K01620 ko00260,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map01100,map01110,map01120,map01130,map01230 - R00751,R06171 RC00312,RC00372 ko00000,ko00001,ko01000 - - - Beta_elim_lyase k59_1670975_1 1207075.PputUW4_01680 3.07e-106 331.0 COG1053@1|root,COG1053@2|Bacteria,1MX84@1224|Proteobacteria,1RRR6@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Succinate dehydrogenase fumarate reductase, flavoprotein subunit - - 1.3.99.5 ko:K16051 ko00984,ko01120,map00984,map01120 - R01834 RC00145 ko00000,ko00001,ko01000 - - - FAD_binding_2 k59_765511_1 765911.Thivi_1782 1.34e-31 113.0 COG3668@1|root,COG3668@2|Bacteria,1N5BN@1224|Proteobacteria 1224|Proteobacteria S ParE toxin of type II toxin-antitoxin system, parDE - - - - - - - - - - - - ParE_toxin k59_765511_2 1033802.SSPSH_003223 1.31e-13 65.5 2DPTZ@1|root,333CW@2|Bacteria,1NE58@1224|Proteobacteria,1SG82@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_765511_3 1121447.JONL01000001_gene519 2.93e-20 87.4 COG0479@1|root,COG0479@2|Bacteria,1MVHS@1224|Proteobacteria,42M2J@68525|delta/epsilon subdivisions,2WK9D@28221|Deltaproteobacteria,2MG2J@213115|Desulfovibrionales 28221|Deltaproteobacteria C TIGRFAM succinate dehydrogenase and fumarate reductase iron-sulfur protein frdB - 1.3.5.1,1.3.5.4 ko:K00240,ko:K00245 ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020 M00009,M00011,M00149,M00150,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_2395 Fer2_3,Fer4_7,Fer4_8 k59_824161_1 243231.GSU3395 1.15e-31 129.0 COG0506@1|root,COG1012@1|root,COG0506@2|Bacteria,COG1012@2|Bacteria,1MV93@1224|Proteobacteria,42MQH@68525|delta/epsilon subdivisions,2WJPV@28221|Deltaproteobacteria,43U56@69541|Desulfuromonadales 28221|Deltaproteobacteria C Oxidizes proline to glutamate for use as a carbon and nitrogen source putA - 1.2.1.88,1.5.5.2 ko:K13821 ko00250,ko00330,ko01100,ko01110,ko01130,map00250,map00330,map01100,map01110,map01130 - R00245,R00707,R00708,R01253,R04444,R04445,R05051 RC00080,RC00083,RC00216,RC00242,RC00255 ko00000,ko00001,ko01000,ko03000 - - iAF987.Gmet_3512 Aldedh,Pro_dh k59_319642_1 1085623.GNIT_3583 1.53e-19 94.4 COG1506@1|root,COG1506@2|Bacteria,1MUJ3@1224|Proteobacteria,1RPAW@1236|Gammaproteobacteria,46468@72275|Alteromonadaceae 1236|Gammaproteobacteria E COG1506 Dipeptidyl aminopeptidases acylaminoacyl-peptidases - - - - - - - - - - - - Peptidase_S9 k59_1330929_1 1298593.TOL_2416 7.83e-45 153.0 COG3665@1|root,COG3665@2|Bacteria,1N2KR@1224|Proteobacteria,1RN5H@1236|Gammaproteobacteria,1XIHT@135619|Oceanospirillales 135619|Oceanospirillales S Domain of unknown function (DUF1989) - - - ko:K09967 - - - - ko00000 - - - DUF1989 k59_1330929_2 1328313.DS2_14324 3.35e-83 250.0 COG3665@1|root,COG3665@2|Bacteria,1N9DM@1224|Proteobacteria,1RR1E@1236|Gammaproteobacteria,464DR@72275|Alteromonadaceae 1236|Gammaproteobacteria S Domain of unknown function (DUF1989) ycgI - - ko:K09967 - - - - ko00000 - - - DUF1989 k59_1220790_1 1227739.Hsw_1997 1.15e-41 151.0 COG2831@1|root,COG2831@2|Bacteria,4PMYI@976|Bacteroidetes,47YEW@768503|Cytophagia 976|Bacteroidetes U Protein of unknown function (DUF3570) - - - - - - - - - - - - DUF3570 k59_1563155_1 1370122.JHXQ01000011_gene1426 2.58e-28 112.0 COG0415@1|root,COG0415@2|Bacteria,1MV9Y@1224|Proteobacteria,2TSDP@28211|Alphaproteobacteria,4B91H@82115|Rhizobiaceae 28211|Alphaproteobacteria L Belongs to the DNA photolyase family phrB GO:0000003,GO:0000166,GO:0000719,GO:0001101,GO:0002252,GO:0002376,GO:0003006,GO:0003674,GO:0003824,GO:0003904,GO:0003913,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005773,GO:0006139,GO:0006259,GO:0006281,GO:0006290,GO:0006325,GO:0006338,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006873,GO:0006874,GO:0006875,GO:0006950,GO:0006952,GO:0006974,GO:0006996,GO:0007154,GO:0007165,GO:0007275,GO:0007623,GO:0008144,GO:0008150,GO:0008152,GO:0009117,GO:0009314,GO:0009414,GO:0009415,GO:0009416,GO:0009605,GO:0009606,GO:0009607,GO:0009615,GO:0009628,GO:0009637,GO:0009638,GO:0009642,GO:0009645,GO:0009646,GO:0009648,GO:0009719,GO:0009725,GO:0009785,GO:0009791,GO:0009881,GO:0009882,GO:0009888,GO:0009893,GO:0009909,GO:0009911,GO:0009987,GO:0010033,GO:0010035,GO:0010073,GO:0010075,GO:0010118,GO:0010228,GO:0010244,GO:0010617,GO:0014070,GO:0016043,GO:0016604,GO:0016829,GO:0016830,GO:0017076,GO:0019222,GO:0019637,GO:0019725,GO:0022414,GO:0022603,GO:0023052,GO:0030003,GO:0030522,GO:0030554,GO:0031323,GO:0031325,GO:0031974,GO:0031981,GO:0032501,GO:0032502,GO:0032553,GO:0032555,GO:0032559,GO:0033554,GO:0033993,GO:0034641,GO:0035639,GO:0036094,GO:0038023,GO:0040008,GO:0042221,GO:0042592,GO:0042726,GO:0042752,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0043207,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0044237,GO:0044238,GO:0044260,GO:0044281,GO:0044422,GO:0044424,GO:0044428,GO:0044444,GO:0044446,GO:0044451,GO:0044464,GO:0046483,GO:0048037,GO:0048507,GO:0048509,GO:0048511,GO:0048518,GO:0048522,GO:0048571,GO:0048573,GO:0048574,GO:0048580,GO:0048582,GO:0048583,GO:0048608,GO:0048638,GO:0048731,GO:0048831,GO:0048856,GO:0048878,GO:0050660,GO:0050662,GO:0050789,GO:0050793,GO:0050794,GO:0050801,GO:0050896,GO:0051094,GO:0051186,GO:0051239,GO:0051240,GO:0051276,GO:0051480,GO:0051607,GO:0051704,GO:0051707,GO:0051716,GO:0055065,GO:0055074,GO:0055080,GO:0055082,GO:0055086,GO:0060089,GO:0061458,GO:0065007,GO:0065008,GO:0070013,GO:0071214,GO:0071478,GO:0071482,GO:0071483,GO:0071704,GO:0071840,GO:0071949,GO:0072387,GO:0072503,GO:0072507,GO:0090304,GO:0097159,GO:0097367,GO:0098542,GO:0098771,GO:0104004,GO:0140097,GO:1900618,GO:1901265,GO:1901360,GO:1901363,GO:1901371,GO:1901564,GO:1901700,GO:1902347,GO:1905421,GO:2000024,GO:2000026,GO:2000028,GO:2000241,GO:2000243,GO:2000377,GO:2000379 4.1.99.3 ko:K01669 - - - - ko00000,ko01000,ko03400 - - - DNA_photolyase,FAD_binding_7 k59_1563155_2 1137799.GZ78_07545 1.67e-58 193.0 COG1804@1|root,COG1804@2|Bacteria,1MW1H@1224|Proteobacteria,1RN9B@1236|Gammaproteobacteria,1XID3@135619|Oceanospirillales 135619|Oceanospirillales C carnitine dehydratase - - 5.1.99.4 ko:K01796 ko00120,ko01100,ko04146,map00120,map01100,map04146 M00104 R08734,R08739 RC02345 ko00000,ko00001,ko00002,ko01000 - - - CoA_transf_3 k59_203768_1 1229909.NSED_07450 1.69e-80 256.0 COG0475@1|root,arCOG01956@2157|Archaea 2157|Archaea P Sodium hydrogen exchanger - - - - - - - - - - - - CBS,Na_H_Exchanger k59_376164_1 1137281.D778_01570 2.1e-201 568.0 COG1530@1|root,COG1530@2|Bacteria,4NED1@976|Bacteroidetes,1HWJC@117743|Flavobacteriia 976|Bacteroidetes J ribonuclease G rng - - ko:K08301 - - - - ko00000,ko01000,ko03009,ko03019 - - - RNase_E_G,S1 k59_601017_1 326427.Cagg_1876 1.71e-08 60.8 COG1316@1|root,COG1316@2|Bacteria,2G6PZ@200795|Chloroflexi,375HZ@32061|Chloroflexia 32061|Chloroflexia K TIGRFAM cell envelope-related function transcriptional attenuator, LytR CpsA family - - - - - - - - - - - - LytR_cpsA_psr k59_765530_1 1219035.NT2_02_02910 7.79e-124 365.0 COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,2TRN7@28211|Alphaproteobacteria,2K1EA@204457|Sphingomonadales 204457|Sphingomonadales C COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes - - 1.8.1.4 ko:K00382 ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00036,M00307,M00532 R00209,R01221,R01698,R03815,R07618,R08549 RC00004,RC00022,RC00583,RC02742,RC02833,RC02834 br01601,ko00000,ko00001,ko00002,ko01000,ko04147 - - - Pyr_redox_2,Pyr_redox_dim k59_376167_1 317936.Nos7107_3399 3.12e-39 146.0 COG2244@1|root,COG2244@2|Bacteria,1G2NK@1117|Cyanobacteria,1HP4C@1161|Nostocales 1117|Cyanobacteria S Membrane protein involved in the export of O-antigen and teichoic acid - - - ko:K03328 - - - - ko00000 2.A.66.2 - - Polysacc_synt_3,Polysacc_synt_C k59_653194_1 630626.EBL_c20290 3.7e-60 204.0 COG2272@1|root,COG2272@2|Bacteria,1MVQZ@1224|Proteobacteria,1RPFW@1236|Gammaproteobacteria 1236|Gammaproteobacteria I Belongs to the type-B carboxylesterase lipase family pnbA - - ko:K03929 - - - - ko00000,ko01000 - CE10 - COesterase k59_653194_2 365528.KB891137_gene428 2.54e-48 164.0 2F120@1|root,33U3I@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_36537_1 543632.JOJL01000027_gene2920 1.16e-54 183.0 COG0240@1|root,COG0240@2|Bacteria,2GJSD@201174|Actinobacteria,4DAAJ@85008|Micromonosporales 201174|Actinobacteria I Glycerol-3-phosphate dehydrogenase gpsA - 1.1.1.94 ko:K00057 ko00564,ko01110,map00564,map01110 - R00842,R00844 RC00029 ko00000,ko00001,ko01000 - - - NAD_Gly3P_dh_C,NAD_Gly3P_dh_N k59_1052863_3 1122947.FR7_4270 1.47e-07 55.8 COG0187@1|root,COG0187@2|Bacteria,1TQ0R@1239|Firmicutes,4H2D7@909932|Negativicutes 909932|Negativicutes L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrB - 5.99.1.3 ko:K02470 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim k59_1616317_1 381666.H16_B1519 2.77e-28 117.0 COG2114@1|root,COG3899@1|root,COG2114@2|Bacteria,COG3899@2|Bacteria,1MUDT@1224|Proteobacteria,2VKH1@28216|Betaproteobacteria,1JZT2@119060|Burkholderiaceae 28216|Betaproteobacteria T adenylyl cyclase class-3 4 guanylyl cyclase - - - - - - - - - - - - AAA_16,DZR,Guanylate_cyc,TPR_4 k59_1052867_1 983545.Glaag_4148 3.4e-39 144.0 COG3391@1|root,COG3391@2|Bacteria,1R8X0@1224|Proteobacteria,1S1R2@1236|Gammaproteobacteria,46BAZ@72275|Alteromonadaceae 1236|Gammaproteobacteria S Methylamine dehydrogenase heavy chain (MADH) mauB - 1.4.9.1 ko:K15229 ko00680,ko01120,map00680,map01120 - R00606 RC00189 ko00000,ko00001,ko01000 - - - Me-amine-dh_H k59_261478_1 1232410.KI421413_gene639 6.2e-37 127.0 COG1917@1|root,COG1917@2|Bacteria,1RJX2@1224|Proteobacteria,42TVK@68525|delta/epsilon subdivisions,2WQ2T@28221|Deltaproteobacteria,43SQH@69541|Desulfuromonadales 28221|Deltaproteobacteria S AraC-like ligand binding domain - - - - - - - - - - - - Cupin_2 k59_601046_2 436308.Nmar_0086 8.49e-43 140.0 COG1958@1|root,arCOG00998@2157|Archaea,41SS5@651137|Thaumarchaeota 651137|Thaumarchaeota K snRNP Sm proteins - - - ko:K04796 - - - - ko00000 - - - LSM k59_1392823_1 981369.JQMJ01000004_gene650 4.97e-102 322.0 COG2272@1|root,COG2272@2|Bacteria,2GJCN@201174|Actinobacteria,2NE76@228398|Streptacidiphilus 201174|Actinobacteria I Carboxylesterase family pnbA - - ko:K03929 - - - - ko00000,ko01000 - CE10 - COesterase k59_1505846_1 1255043.TVNIR_3015 4.37e-18 82.0 COG2847@1|root,COG2847@2|Bacteria,1MZ3M@1224|Proteobacteria,1SCJD@1236|Gammaproteobacteria,1WYZ4@135613|Chromatiales 135613|Chromatiales S Copper chaperone PCu(A)C - - - ko:K09796 - - - - ko00000,ko03110 - - - PCuAC k59_1505846_2 929713.NIASO_05895 7.52e-05 51.2 COG3012@1|root,COG3012@2|Bacteria 2|Bacteria - - yccF - - ko:K07039 - - - - ko00000 - - - HTH_psq,SEC-C,TPR_19 k59_319699_1 498211.CJA_2002 2.4e-46 172.0 COG0760@1|root,COG0760@2|Bacteria,1MWV0@1224|Proteobacteria,1RMT5@1236|Gammaproteobacteria,1FH1Q@10|Cellvibrio 1236|Gammaproteobacteria O SurA N-terminal domain ppiD GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006457,GO:0008150,GO:0009897,GO:0009986,GO:0009987,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0031233,GO:0042802,GO:0044425,GO:0044459,GO:0044464,GO:0061077,GO:0071575,GO:0071944,GO:0098552 5.2.1.8 ko:K03770 - - - - ko00000,ko01000,ko03110 - - - Rotamase,Rotamase_2,Rotamase_3,SurA_N_3 k59_991126_1 1122137.AQXF01000003_gene2291 8.52e-125 364.0 COG0772@1|root,COG0772@2|Bacteria,1MVDB@1224|Proteobacteria,2TQSA@28211|Alphaproteobacteria 28211|Alphaproteobacteria D Belongs to the SEDS family ftsW - - ko:K03588 ko04112,map04112 - - - ko00000,ko00001,ko02000,ko03036 2.A.103.1 - - FTSW_RODA_SPOVE k59_203808_1 279238.Saro_3453 2.82e-06 56.2 COG1629@1|root,COG4771@2|Bacteria,1R8R0@1224|Proteobacteria,2TTH0@28211|Alphaproteobacteria,2K0E8@204457|Sphingomonadales 204457|Sphingomonadales P TonB dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_376199_1 999541.bgla_1g03870 1.84e-20 84.0 COG1826@1|root,COG1826@2|Bacteria,1N6S4@1224|Proteobacteria,2VVT6@28216|Betaproteobacteria,1K977@119060|Burkholderiaceae 28216|Betaproteobacteria U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system tatA - - ko:K03116 ko03060,ko03070,map03060,map03070 M00336 - - ko00000,ko00001,ko00002,ko02044 2.A.64 - - MttA_Hcf106 k59_376199_2 1156919.QWC_12898 4.2e-28 110.0 COG1826@1|root,COG1826@2|Bacteria,1N73F@1224|Proteobacteria,2VVPX@28216|Betaproteobacteria,3T4FJ@506|Alcaligenaceae 28216|Betaproteobacteria U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation tatB - - ko:K03117 ko03060,ko03070,map03060,map03070 M00336 - - ko00000,ko00001,ko00002,ko02044 2.A.64 - - MttA_Hcf106 k59_376199_3 511.JT27_06895 1.27e-22 94.0 COG0805@1|root,COG0805@2|Bacteria,1MVAY@1224|Proteobacteria,2VI2H@28216|Betaproteobacteria,3T2MX@506|Alcaligenaceae 28216|Betaproteobacteria U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides tatC - - ko:K03118 ko03060,ko03070,map03060,map03070 M00336 - - ko00000,ko00001,ko00002,ko02044 2.A.64 - - TatC k59_261495_1 402777.KB235904_gene2884 5.48e-53 177.0 COG1741@1|root,COG1741@2|Bacteria,1G2VZ@1117|Cyanobacteria,1H98A@1150|Oscillatoriales 1117|Cyanobacteria S Belongs to the pirin family - - - ko:K06911 - - - - ko00000 - - - Pirin,Pirin_C k59_1164440_1 1123366.TH3_19407 1.18e-98 295.0 COG2801@1|root,COG2801@2|Bacteria,1MVQ9@1224|Proteobacteria,2TTHG@28211|Alphaproteobacteria,2JQIQ@204441|Rhodospirillales 204441|Rhodospirillales L Integrase core domain - - - - - - - - - - - - rve k59_884618_1 1415778.JQMM01000001_gene99 2.57e-85 265.0 COG0860@1|root,COG0860@2|Bacteria,1MUQK@1224|Proteobacteria,1RMP1@1236|Gammaproteobacteria,1J4PG@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M N-acetylmuramoyl-L-alanine amidase amiC - 3.5.1.28 ko:K01448 ko01503,map01503 M00727 R04112 RC00064,RC00141 ko00000,ko00001,ko00002,ko01000,ko01011,ko03036 - - - AMIN,Amidase_3,LysM k59_36572_1 1144275.COCOR_02593 4.7e-45 166.0 COG1020@1|root,COG1020@2|Bacteria,1QK4F@1224|Proteobacteria,42NH4@68525|delta/epsilon subdivisions,2WN7A@28221|Deltaproteobacteria,2YTZA@29|Myxococcales 28221|Deltaproteobacteria Q non-ribosomal peptide synthetase - - - ko:K16416 ko01052,map01052 - - - ko00000,ko00001,ko01008 - - - AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase k59_435676_1 158500.BV97_03359 6.36e-80 250.0 COG0845@1|root,COG0845@2|Bacteria,1NQZ0@1224|Proteobacteria,2U105@28211|Alphaproteobacteria,2K16Y@204457|Sphingomonadales 204457|Sphingomonadales M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - - - - - - - - - - HlyD_D23 k59_1571574_1 1397278.AYMV01000015_gene2193 8.03e-45 164.0 COG0707@1|root,COG0707@2|Bacteria,2GJEM@201174|Actinobacteria,4FM76@85023|Microbacteriaceae 201174|Actinobacteria M Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) murG - 2.4.1.227,6.3.2.8 ko:K01924,ko:K02563 ko00471,ko00550,ko01100,ko01502,ko04112,map00471,map00550,map01100,map01502,map04112 - R03193,R05032,R05662 RC00005,RC00049,RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - GT28 - Glyco_tran_28_C,Glyco_transf_28 k59_1736826_1 436308.Nmar_0088 1.18e-93 298.0 COG1201@1|root,arCOG00557@2157|Archaea,41S8P@651137|Thaumarchaeota 651137|Thaumarchaeota L DEAD/H associated - - - ko:K03724 - - - - ko00000,ko01000,ko03400 - - - DEAD,DEAD_assoc,Helicase_C k59_546896_1 1173026.Glo7428_1477 2e-82 279.0 COG1858@1|root,COG1858@2|Bacteria,1G358@1117|Cyanobacteria 1117|Cyanobacteria P PFAM Di-haem cytochrome c peroxidase - - - - - - - - - - - - CCP_MauG,Cytochrom_C k59_1113716_2 926569.ANT_03820 9.8e-14 70.5 COG2006@1|root,COG2006@2|Bacteria,2G7GH@200795|Chloroflexi 200795|Chloroflexi S 4fe-4S ferredoxin, iron-sulfur binding domain protein - - - - - - - - - - - - - k59_1172739_1 1117314.PCIT_10894 1.13e-13 77.8 COG1345@1|root,COG2911@1|root,COG3210@1|root,COG3637@1|root,COG5295@1|root,COG5625@1|root,COG1345@2|Bacteria,COG2911@2|Bacteria,COG3210@2|Bacteria,COG3637@2|Bacteria,COG5295@2|Bacteria,COG5625@2|Bacteria,1P8N9@1224|Proteobacteria,1SCTK@1236|Gammaproteobacteria 1236|Gammaproteobacteria G Hep Hag repeat protein - - - - - - - - - - - - Cadherin,DUF4347,DUF5122,He_PIG,OmpA_membrane k59_212100_1 639030.JHVA01000001_gene1136 5.04e-75 240.0 COG1239@1|root,COG1239@2|Bacteria,3Y3FM@57723|Acidobacteria,2JHY2@204432|Acidobacteriia 204432|Acidobacteriia H Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX - - 6.6.1.1 ko:K03405 ko00860,ko01100,ko01110,map00860,map01100,map01110 - R03877 RC01012 ko00000,ko00001,ko01000 - - - Sigma54_activat k59_609596_2 575540.Isop_3476 1.16e-64 214.0 COG3875@1|root,COG3875@2|Bacteria,2IZBN@203682|Planctomycetes 203682|Planctomycetes S conserved protein (DUF2088) - - - - - - - - - - - - DUF2088 k59_546898_1 1229909.NSED_02310 1.91e-80 252.0 COG0475@1|root,arCOG01955@2157|Archaea,41SG1@651137|Thaumarchaeota 651137|Thaumarchaeota P Sodium hydrogen exchanger - - - ko:K03455 - - - - ko00000 2.A.37 - - Na_H_Exchanger k59_662058_1 1403819.BATR01000162_gene5406 2.68e-16 79.7 COG2960@1|root,COG2960@2|Bacteria,46ZKH@74201|Verrucomicrobia,2IVHR@203494|Verrucomicrobiae 203494|Verrucomicrobiae S Protein of unknown function (DUF1552) - - - - - - - - - - - - HXXSHH k59_1338934_1 1278073.MYSTI_02061 8.57e-46 168.0 COG3321@1|root,COG3321@2|Bacteria,1R89Z@1224|Proteobacteria,42M10@68525|delta/epsilon subdivisions 1224|Proteobacteria Q Acyl transferase domain in polyketide synthase (PKS) enzymes. - - - ko:K04786 ko01053,map01053 - - - ko00000,ko00001,ko01004,ko01008 - - - Acyl_transf_1,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,PS-DH,Thioesterase,ketoacyl-synt k59_212104_1 1122135.KB893134_gene3795 1.14e-118 350.0 COG3572@1|root,COG3572@2|Bacteria,1MU47@1224|Proteobacteria,2TRPT@28211|Alphaproteobacteria 28211|Alphaproteobacteria H glutamate--cysteine ligase gshA - 6.3.2.2 ko:K01919 ko00270,ko00480,ko01100,map00270,map00480,map01100 M00118 R00894,R10993 RC00064,RC00090 ko00000,ko00001,ko00002,ko01000 - - - GCS2 k59_1452494_1 330214.NIDE3311 5.82e-156 442.0 COG3794@1|root,COG3794@2|Bacteria 2|Bacteria C PFAM blue (type 1) copper domain protein - - - - - - - - - - - - CarboxypepD_reg,fn3_3 k59_1679205_1 272123.Anacy_0494 2.25e-22 99.4 COG5421@1|root,COG5421@2|Bacteria,1G02P@1117|Cyanobacteria,1HJTW@1161|Nostocales 1117|Cyanobacteria L COGs COG5421 Transposase - - - - - - - - - - - - DDE_Tnp_1,DUF4277 k59_999810_3 377629.TERTU_1096 2.14e-13 74.3 COG4972@1|root,COG4972@2|Bacteria,1N0HS@1224|Proteobacteria,1SAQC@1236|Gammaproteobacteria,2PQB1@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria NU Pilus assembly protein mshI - - ko:K12279 - - - - ko00000,ko02044 - - - - k59_269855_1 1454004.AW11_01649 1.1e-123 365.0 COG0015@1|root,COG0015@2|Bacteria,1MV4B@1224|Proteobacteria,2VI2T@28216|Betaproteobacteria,1KPT1@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria F Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily purB - 4.3.2.2 ko:K01756 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048,M00049 R01083,R04559 RC00379,RC00444,RC00445 ko00000,ko00001,ko00002,ko01000 - - - ASL_C,Lyase_1 k59_1338970_1 1122612.AUBA01000008_gene2323 3.8e-20 91.3 COG0217@1|root,COG0217@2|Bacteria,1MW3X@1224|Proteobacteria,2TRSK@28211|Alphaproteobacteria,2K0KW@204457|Sphingomonadales 204457|Sphingomonadales K transcriptional regulatory protein - - - - - - - - - - - - Transcrip_reg k59_1228625_1 1869.MB27_41745 1.02e-35 137.0 COG1396@1|root,COG3800@1|root,COG1396@2|Bacteria,COG3800@2|Bacteria,2GMWU@201174|Actinobacteria,4DGHN@85008|Micromonosporales 201174|Actinobacteria K IrrE N-terminal-like domain hipB - - ko:K21686 - - - - ko00000,ko03000 - - - HTH_19,HTH_3,HTH_31,Peptidase_M78 k59_1228625_2 1110697.NCAST_05_01190 1.91e-09 59.7 COG2141@1|root,COG2141@2|Bacteria,2GJ6T@201174|Actinobacteria,4FX1U@85025|Nocardiaceae 201174|Actinobacteria C Luciferase-like monooxygenase - - - - - - - - - - - - Bac_luciferase k59_1452509_1 436308.Nmar_1037 7.82e-193 550.0 COG1793@1|root,arCOG01347@2157|Archaea,41SCK@651137|Thaumarchaeota 651137|Thaumarchaeota L DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair lig - 6.5.1.1,6.5.1.6,6.5.1.7 ko:K10747 ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430 - R00381,R00382,R10822,R10823 RC00005 ko00000,ko00001,ko01000,ko03032,ko03400 - - - DNA_ligase_A_C,DNA_ligase_A_M,DNA_ligase_A_N k59_44488_1 1227453.C444_10259 8.7e-48 165.0 COG1653@1|root,arCOG00151@2157|Archaea,2Y2AY@28890|Euryarchaeota,23Z4Y@183963|Halobacteria 183963|Halobacteria G COG1653 ABC-type sugar transport system, periplasmic component - - - - - - - - - - - - - k59_1514186_1 1250232.JQNJ01000001_gene546 5.75e-55 177.0 COG4319@1|root,COG4319@2|Bacteria,4PMRD@976|Bacteroidetes,1I1CU@117743|Flavobacteriia 976|Bacteroidetes S SnoaL-like domain - - - - - - - - - - - - DUF4440 k59_1789248_1 1280001.BAOA01000213_gene49 5.26e-25 111.0 COG3501@1|root,COG3501@2|Bacteria,1MU7Q@1224|Proteobacteria,1RMZS@1236|Gammaproteobacteria,1XUHW@135623|Vibrionales 135623|Vibrionales M protein conserved in bacteria vgrG1 GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0006464,GO:0006807,GO:0006996,GO:0007010,GO:0007015,GO:0008144,GO:0008150,GO:0008152,GO:0008154,GO:0009405,GO:0009987,GO:0016043,GO:0016874,GO:0016879,GO:0016881,GO:0017076,GO:0018149,GO:0018153,GO:0018193,GO:0018199,GO:0018205,GO:0018262,GO:0018995,GO:0019538,GO:0022411,GO:0030029,GO:0030036,GO:0030042,GO:0030430,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032984,GO:0033643,GO:0033646,GO:0035639,GO:0036094,GO:0036211,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043412,GO:0043624,GO:0043656,GO:0043657,GO:0043933,GO:0044215,GO:0044216,GO:0044217,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044419,GO:0046872,GO:0051261,GO:0051704,GO:0071704,GO:0071840,GO:0097159,GO:0097367,GO:0097435,GO:1901265,GO:1901363,GO:1901564 - ko:K11904 ko03070,map03070 M00334 - - ko00000,ko00001,ko00002,ko02044 3.A.23.1 - - PG_binding_1,Phage_GPD k59_1452512_1 522306.CAP2UW1_2271 6.24e-92 280.0 COG1219@1|root,COG1219@2|Bacteria,1MVQK@1224|Proteobacteria,2VIEU@28216|Betaproteobacteria,1KPS0@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria O ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP clpX - - ko:K03544 ko04112,map04112 - - - ko00000,ko00001,ko03110 - - - AAA_2,ClpB_D2-small,zf-C4_ClpX k59_1452512_2 375286.mma_1531 1.96e-09 57.4 COG0740@1|root,COG0740@2|Bacteria,1MV46@1224|Proteobacteria,2VHAZ@28216|Betaproteobacteria,4723Y@75682|Oxalobacteraceae 28216|Betaproteobacteria O Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins clpP - 3.4.21.92 ko:K01358 ko04112,ko04212,map04112,map04212 - - - ko00000,ko00001,ko01000,ko01002 - - - CLP_protease k59_1282621_1 1122137.AQXF01000001_gene3032 9.2e-97 295.0 COG0621@1|root,COG0621@2|Bacteria,1MURS@1224|Proteobacteria,2TQN6@28211|Alphaproteobacteria 28211|Alphaproteobacteria J Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine miaB - 2.8.4.3 ko:K06168 - - R10645,R10646,R10647 RC00003,RC00980,RC03221,RC03222 ko00000,ko01000,ko03016 - - - Radical_SAM,TRAM,UPF0004 k59_155017_2 266117.Rxyl_1516 3.13e-26 110.0 COG0481@1|root,COG0481@2|Bacteria,2GJAB@201174|Actinobacteria,4CP62@84995|Rubrobacteria 84995|Rubrobacteria M Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner lepA - - ko:K03596 ko05134,map05134 - - - ko00000,ko00001 - - - EFG_C,GTP_EFTU,GTP_EFTU_D2,LepA_C k59_1789259_1 436308.Nmar_0868 1.33e-87 271.0 COG0064@1|root,arCOG01718@2157|Archaea,41S9S@651137|Thaumarchaeota 651137|Thaumarchaeota J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) gatB - 6.3.5.6,6.3.5.7 ko:K02434 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - GatB_N,GatB_Yqey k59_1113770_1 936455.KI421499_gene208 1.05e-26 110.0 28KNR@1|root,2Z9F7@2|Bacteria,1NC4P@1224|Proteobacteria,2TSTI@28211|Alphaproteobacteria,3JTPT@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S Glycosyl hydrolase family 79, N-terminal domain - - - - - - - - - - - - Glyco_hydro_79n k59_155018_1 1229909.NSED_03170 5.31e-97 317.0 arCOG08231@1|root,arCOG08231@2157|Archaea,41T6Q@651137|Thaumarchaeota 651137|Thaumarchaeota L Lamin Tail Domain - - - - - - - - - - - - LTD k59_1282630_1 1336243.JAEA01000013_gene3269 1.19e-26 113.0 COG1835@1|root,COG1835@2|Bacteria,1MV2W@1224|Proteobacteria,2TRT8@28211|Alphaproteobacteria,1JTVR@119045|Methylobacteriaceae 28211|Alphaproteobacteria I PFAM Acyltransferase - - - - - - - - - - - - Acyl_transf_3 k59_1679254_1 316407.1742039 9.77e-116 341.0 COG1226@1|root,COG1226@2|Bacteria,1R3QQ@1224|Proteobacteria,1RPFS@1236|Gammaproteobacteria,3XNGG@561|Escherichia 1236|Gammaproteobacteria P Potassium channel kch GO:0003674,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0009987,GO:0015075,GO:0015318,GO:0015672,GO:0016020,GO:0016021,GO:0016043,GO:0022607,GO:0022857,GO:0022890,GO:0030001,GO:0031224,GO:0031226,GO:0034220,GO:0042802,GO:0043933,GO:0044085,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055085,GO:0065003,GO:0071804,GO:0071805,GO:0071840,GO:0071944,GO:0098655,GO:0098660,GO:0098662 - ko:K10716 - - - - ko00000,ko02000 1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6 - iEC042_1314.EC042_1304,iECUMN_1333.ECUMN_1549 Ion_trans_2,TrkA_N k59_1736879_1 1265503.KB905165_gene1050 1.74e-07 50.1 2DMKI@1|root,32S70@2|Bacteria,1N1FV@1224|Proteobacteria,1S778@1236|Gammaproteobacteria 1236|Gammaproteobacteria S SpoIIAA-like VVA0543 - - - - - - - - - - - SpoIIAA-like k59_1736879_2 1121923.GPUN_0450 3.37e-51 166.0 2CNK3@1|root,31TH7@2|Bacteria,1R38H@1224|Proteobacteria,1S7X7@1236|Gammaproteobacteria,46DFI@72275|Alteromonadaceae 1236|Gammaproteobacteria S Protein of Unknown function (DUF2784) - - - - - - - - - - - - DUF2784 k59_723083_1 323848.Nmul_A0224 1.38e-91 274.0 COG0708@1|root,COG0708@2|Bacteria,1MVII@1224|Proteobacteria,2VI74@28216|Betaproteobacteria,372JW@32003|Nitrosomonadales 28216|Betaproteobacteria L Exodeoxyribonuclease III xth exoA - 3.1.11.2 ko:K01142 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - Exo_endo_phos k59_609688_1 391612.CY0110_08276 2.16e-52 191.0 COG2304@1|root,COG3210@1|root,COG2304@2|Bacteria,COG3210@2|Bacteria 2|Bacteria U domain, Protein - - - - - - - - - - - - CHU_C,Calx-beta,DUF11,DUF4214,HemolysinCabind,SdrD_B,VWA,VWA_2 k59_1452534_1 1260251.SPISAL_04555 2.98e-50 171.0 COG1420@1|root,COG1420@2|Bacteria,1MVX4@1224|Proteobacteria,1RR2F@1236|Gammaproteobacteria,1WXB7@135613|Chromatiales 135613|Chromatiales K Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons hrcA - - ko:K03705 - - - - ko00000,ko03000 - - - HrcA,HrcA_DNA-bdg k59_944026_1 1283300.ATXB01000001_gene2049 1.16e-59 199.0 COG0007@1|root,COG1648@1|root,COG0007@2|Bacteria,COG1648@2|Bacteria,1MUI0@1224|Proteobacteria,1RM9V@1236|Gammaproteobacteria,1XEV7@135618|Methylococcales 135618|Methylococcales H Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme cysG - 1.3.1.76,2.1.1.107,4.99.1.4 ko:K02302 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R02864,R03194,R03947 RC00003,RC00871,RC01012,RC01034 ko00000,ko00001,ko00002,ko01000 - - - CysG_dimeriser,NAD_binding_7,Sirohm_synth_M,TP_methylase k59_546964_1 391615.ABSJ01000057_gene1523 1.29e-68 223.0 COG0195@1|root,COG0195@2|Bacteria,1MWT7@1224|Proteobacteria,1RNQS@1236|Gammaproteobacteria,1J4C0@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria K Participates in both transcription termination and antitermination nusA GO:0001000,GO:0001121,GO:0001125,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006353,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0019899,GO:0019904,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043175,GO:0043244,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0070063,GO:0071704,GO:0080090,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576,GO:1903506,GO:2000112,GO:2001141 - ko:K02600 - - - - ko00000,ko03009,ko03021 - - - HHH_5,KH_5,NusA_N,S1 k59_893064_1 983545.Glaag_2467 1.77e-54 191.0 COG4774@1|root,COG4774@2|Bacteria,1NMCN@1224|Proteobacteria,1T411@1236|Gammaproteobacteria,469IU@72275|Alteromonadaceae 1236|Gammaproteobacteria P TonB dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_723100_1 1121920.AUAU01000004_gene718 2.33e-55 189.0 COG2304@1|root,COG2304@2|Bacteria,3Y33Z@57723|Acidobacteria 57723|Acidobacteria S Peptidase M64 N-terminus - - - - - - - - - - - - M64_N,Peptidase_M64 k59_1339038_1 1288826.MSNKSG1_15037 4.13e-46 157.0 COG0189@1|root,COG0189@2|Bacteria,1MWQA@1224|Proteobacteria,1RPD7@1236|Gammaproteobacteria,4664B@72275|Alteromonadaceae 1236|Gammaproteobacteria HJ COG0189 Glutathione synthase Ribosomal protein S6 modification enzyme (glutaminyl transferase) - - - ko:K05844 - - - - ko00000,ko01000,ko03009 - - - RimK k59_1282666_1 537011.PREVCOP_04848 6e-46 162.0 COG0078@1|root,COG0078@2|Bacteria,4NEYX@976|Bacteroidetes,2FNR9@200643|Bacteroidia 976|Bacteroidetes E Belongs to the ATCase OTCase family argF GO:0000050,GO:0003674,GO:0003824,GO:0004585,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0016743,GO:0019627,GO:0019752,GO:0034641,GO:0042450,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.1.3.11,2.1.3.9 ko:K09065,ko:K13043 ko00220,ko01100,ko01230,map00220,map01100,map01230 M00845 R07245,R08937 RC00096 ko00000,ko00001,ko00002,ko01000 - - - OTCace,OTCace_N k59_435798_2 1049564.TevJSym_bu00100 9.15e-74 224.0 COG0250@1|root,COG0250@2|Bacteria,1MU14@1224|Proteobacteria,1RMW0@1236|Gammaproteobacteria,1J4SH@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria K Participates in transcription elongation, termination and antitermination nusG - - ko:K02601 - - - - ko00000,ko03009,ko03021 - - - KOW,NusG k59_1452549_2 1255043.TVNIR_1650 2.94e-20 93.6 COG2010@1|root,COG2010@2|Bacteria,1N3PN@1224|Proteobacteria,1RNS0@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Nitrite reductase nirS - 1.7.2.1,1.7.99.1 ko:K15864 ko00910,ko01120,map00910,map01120 M00529 R00143,R00783,R00785 RC00086,RC02797 ko00000,ko00001,ko00002,ko01000 - - - Cytochrom_D1,Cytochrome_CBB3 k59_1514251_1 1449353.JQMQ01000005_gene1442 3.03e-66 214.0 COG0006@1|root,COG0006@2|Bacteria,2GM7D@201174|Actinobacteria,2NF4W@228398|Streptacidiphilus 201174|Actinobacteria E Creatinase/Prolidase N-terminal domain pepE - 3.4.13.9 ko:K01271,ko:K01274 - - - - ko00000,ko01000,ko01002 - - - Creatinase_N,Peptidase_M24 k59_893081_1 1230457.C476_12681 4.22e-10 64.7 arCOG04555@1|root,arCOG04555@2157|Archaea,2XUY2@28890|Euryarchaeota,23TMB@183963|Halobacteria 183963|Halobacteria S Integral membrane protein CcmA involved in cell shape determination - - - - - - - - - - - - Bactofilin k59_155071_2 2055.JNXA01000001_gene1727 1.92e-11 70.5 COG0739@1|root,COG0739@2|Bacteria,2I9IY@201174|Actinobacteria,4GB6S@85026|Gordoniaceae 201174|Actinobacteria M Peptidase family M23 - - - - - - - - - - - - Peptidase_M23 k59_1061069_1 1509405.GV67_00590 4.56e-05 52.4 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2TQS3@28211|Alphaproteobacteria,4B73R@82115|Rhizobiaceae 28211|Alphaproteobacteria T Diguanylate cyclase - - - - - - - - - - - - CHASE,EAL,GGDEF,PAS_3 k59_100395_1 269798.CHU_0382 3.16e-06 53.1 COG2353@1|root,COG2353@2|Bacteria,4NT3W@976|Bacteroidetes,47R2B@768503|Cytophagia 976|Bacteroidetes S Belongs to the UPF0312 family - - - - - - - - - - - - YceI k59_1736914_1 342113.DM82_3850 4.63e-45 166.0 COG0417@1|root,COG0417@2|Bacteria,1MVY9@1224|Proteobacteria,2VHID@28216|Betaproteobacteria,1K16P@119060|Burkholderiaceae 28216|Betaproteobacteria L SMART DNA-directed DNA polymerase B polB - 2.7.7.7 ko:K02336 - - - - ko00000,ko01000,ko03400 - - - DNA_pol_B,DNA_pol_B_exo1 k59_1061076_1 1121920.AUAU01000006_gene324 8.7e-48 166.0 COG3185@1|root,COG3185@2|Bacteria,3Y2XN@57723|Acidobacteria 57723|Acidobacteria E Acyclic terpene utilisation family protein AtuA - - - - - - - - - - - - AtuA k59_44549_2 1283300.ATXB01000001_gene2014 1.32e-33 123.0 COG1678@1|root,COG1678@2|Bacteria,1RCXM@1224|Proteobacteria,1S3YV@1236|Gammaproteobacteria,1XEAF@135618|Methylococcales 135618|Methylococcales K Belongs to the UPF0301 (AlgH) family - - - ko:K07735 - - - - ko00000,ko03000 - - - DUF179 k59_832652_1 13689.BV96_02914 4.07e-27 114.0 COG4774@1|root,COG4774@2|Bacteria,1QPVC@1224|Proteobacteria,2U4WC@28211|Alphaproteobacteria,2K32N@204457|Sphingomonadales 204457|Sphingomonadales P TonB-dependent Receptor Plug Domain - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_328823_2 1288494.EBAPG3_4490 7.53e-55 174.0 COG0292@1|root,COG0292@2|Bacteria,1RGU2@1224|Proteobacteria,2VRWF@28216|Betaproteobacteria,3738Y@32003|Nitrosomonadales 28216|Betaproteobacteria J Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit rplT - - ko:K02887 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L20 k59_1572409_1 103690.17131969 9.18e-54 198.0 COG0642@1|root,COG0784@1|root,COG2198@1|root,COG2202@1|root,COG3452@1|root,COG3829@1|root,COG0784@2|Bacteria,COG2198@2|Bacteria,COG2202@2|Bacteria,COG2205@2|Bacteria,COG3452@2|Bacteria,COG3829@2|Bacteria,1G09B@1117|Cyanobacteria,1HRJ1@1161|Nostocales 1117|Cyanobacteria T Histidine Phosphotransfer domain - - - - - - - - - - - - CHASE,GAF,HATPase_c,HisKA,Hpt,PAS_3,PAS_9,Response_reg k59_774422_1 702113.PP1Y_AT24676 6.33e-39 142.0 COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,2TR1I@28211|Alphaproteobacteria,2K0GG@204457|Sphingomonadales 204457|Sphingomonadales EH COG0028 Thiamine pyrophosphate-requiring enzymes acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase ilvB - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_774422_2 702113.PP1Y_AT24692 9.01e-49 165.0 COG0324@1|root,COG0324@2|Bacteria,1MUB2@1224|Proteobacteria,2TR8Z@28211|Alphaproteobacteria,2K0WU@204457|Sphingomonadales 204457|Sphingomonadales J Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) miaA - 2.5.1.75 ko:K00791 ko00908,ko01100,ko01110,map00908,map01100,map01110 - R01122 RC02820 ko00000,ko00001,ko01000,ko01006,ko03016 - - - IPPT k59_1515013_1 1033736.CAHK01000027_gene1609 2.64e-39 149.0 COG0318@1|root,COG0318@2|Bacteria,2GIUC@201174|Actinobacteria,4F8D6@85019|Brevibacteriaceae 201174|Actinobacteria IQ AMP-binding enzyme C-terminal domain - - - ko:K00666 - - - - ko00000,ko01000,ko01004 - - - AMP-binding,AMP-binding_C k59_1114551_1 1280950.HJO_13121 1.79e-25 108.0 COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2TRUI@28211|Alphaproteobacteria,43XNB@69657|Hyphomonadaceae 28211|Alphaproteobacteria T Adenylate cyclase - - - - - - - - - - - - TIR_2,TPR_16,TPR_8,Trans_reg_C k59_1229340_1 1122137.AQXF01000005_gene1126 1.17e-65 205.0 2E6A6@1|root,330Y2@2|Bacteria,1NB20@1224|Proteobacteria,2UGF9@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_270730_1 1459636.NTE_02269 5.31e-79 241.0 COG0431@1|root,arCOG04624@2157|Archaea 2157|Archaea S NAD(P)H-dependent FMN reductase ssuE1 - 1.5.1.38 ko:K00299 ko00740,ko00920,ko01100,map00740,map00920,map01100 - R05706,R07210,R10206 RC00126,RC01779,RC02556 ko00000,ko00001,ko01000 - - - FMN_red k59_893991_2 29581.BW37_03310 6.95e-23 105.0 COG1404@1|root,COG1404@2|Bacteria,1MVJE@1224|Proteobacteria 1224|Proteobacteria O Belongs to the peptidase S8 family - - - - - - - - - - - - Inhibitor_I9,PA,Peptidase_S8 k59_833302_1 1123267.JONN01000001_gene1987 6.55e-33 130.0 COG0457@1|root,COG0457@2|Bacteria,1RHFI@1224|Proteobacteria,2TXPR@28211|Alphaproteobacteria,2KEIN@204457|Sphingomonadales 204457|Sphingomonadales S Putative 2OG-Fe(II) oxygenase - - - - - - - - - - - - 2OG-FeII_Oxy_5 k59_1680232_1 1565314.OA34_09990 1.5e-29 117.0 COG2838@1|root,COG2838@2|Bacteria,1MV6Q@1224|Proteobacteria,42MY0@68525|delta/epsilon subdivisions,2YMT1@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Isocitrate dehydrogenase icd - 1.1.1.42 ko:K00031 ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146 M00009,M00010,M00173,M00740 R00267,R00268,R01899 RC00001,RC00084,RC00114,RC00626,RC02801 br01601,ko00000,ko00001,ko00002,ko01000 - - - IDH k59_1061858_1 1254432.SCE1572_32510 4.69e-48 162.0 COG0500@1|root,COG2226@2|Bacteria,1N4AC@1224|Proteobacteria,43AT1@68525|delta/epsilon subdivisions,2X67C@28221|Deltaproteobacteria,2Z3A4@29|Myxococcales 28221|Deltaproteobacteria Q Nodulation protein S (NodS) - - - - - - - - - - - - Methyltransf_31 k59_1114563_1 1038859.AXAU01000026_gene2330 9.96e-70 227.0 COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria,2TT1G@28211|Alphaproteobacteria,3JQQ7@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria E Bacterial extracellular solute-binding proteins, family 5 Middle - - - ko:K02035 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - SBP_bac_5 k59_1339834_1 1122137.AQXF01000003_gene2372 9.22e-65 213.0 COG3844@1|root,COG3844@2|Bacteria,1MUKN@1224|Proteobacteria,2TR62@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively kynU - 3.7.1.3 ko:K01556 ko00380,ko01100,map00380,map01100 M00038 R00987,R02668,R03936 RC00284,RC00415 ko00000,ko00001,ko00002,ko01000 - - - Aminotran_5 k59_547716_1 1088721.NSU_3872 6.02e-121 357.0 COG0034@1|root,COG0034@2|Bacteria,1MU0V@1224|Proteobacteria,2TR8V@28211|Alphaproteobacteria,2K0C0@204457|Sphingomonadales 204457|Sphingomonadales F Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine purF - 2.4.2.14 ko:K00764 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048 R01072 RC00010,RC02724,RC02752 ko00000,ko00001,ko00002,ko01000,ko01002 - - - GATase_7,Pribosyltran k59_328843_1 3218.PP1S333_10V6.1 9.47e-22 95.1 COG0566@1|root,KOG0838@2759|Eukaryota,37MIT@33090|Viridiplantae,3G7FT@35493|Streptophyta 35493|Streptophyta A tRNA rRNA methyltransferase (SpoU) family protein - GO:0001510,GO:0002128,GO:0002938,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008173,GO:0008175,GO:0008757,GO:0009020,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:0106050,GO:0140098,GO:0140101,GO:1901360 - - - - - - - - - - SpoU_methylase k59_328843_2 106370.Francci3_1507 3.31e-19 85.5 COG1651@1|root,COG1651@2|Bacteria,2IT6U@201174|Actinobacteria 201174|Actinobacteria O DSBA-like thioredoxin domain - - - - - - - - - - - - DSBA k59_1339838_1 745310.G432_18260 2.77e-28 112.0 COG0596@1|root,COG0596@2|Bacteria,1MVVX@1224|Proteobacteria,2TT0S@28211|Alphaproteobacteria,2K14Q@204457|Sphingomonadales 204457|Sphingomonadales S Alpha beta hydrolase - - - - - - - - - - - - Abhydrolase_1,Abhydrolase_6 k59_1339838_2 1122137.AQXF01000002_gene428 2.08e-81 254.0 COG1171@1|root,COG1171@2|Bacteria,1MVWJ@1224|Proteobacteria,2TQN9@28211|Alphaproteobacteria 28211|Alphaproteobacteria E threonine dehydratase ilvA - 4.3.1.19 ko:K01754 ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230 M00570 R00220,R00996 RC00418,RC02600 ko00000,ko00001,ko00002,ko01000 - - - ACT,ACT_4,PALP k59_944831_1 1304275.C41B8_07607 2.33e-08 55.8 COG0215@1|root,COG0215@2|Bacteria,1MV8H@1224|Proteobacteria,1RP5K@1236|Gammaproteobacteria 1236|Gammaproteobacteria J Belongs to the class-I aminoacyl-tRNA synthetase family cysS GO:0000166,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.1.1.16 ko:K01883 ko00970,map00970 M00359,M00360 R03650 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iECUMN_1333.ECUMN_0566,iJN746.PP_2905 DALR_2,tRNA-synt_1e,tRNA-synt_1g k59_944831_2 1122137.AQXF01000002_gene55 2.33e-74 229.0 COG0565@1|root,COG0565@2|Bacteria,1N47Y@1224|Proteobacteria,2TS8J@28211|Alphaproteobacteria 28211|Alphaproteobacteria J Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA trmJ - - ko:K02533 - - - - ko00000,ko01000,ko03016 - - - DUF559,SpoU_methylase k59_492271_1 945713.IALB_1326 2.09e-29 108.0 COG3536@1|root,COG3536@2|Bacteria 2|Bacteria S Protein of unknown function (DUF971) - - - ko:K03593 - - - - ko00000,ko03029,ko03036 - - - DUF971 k59_492271_2 945713.IALB_1325 1.18e-20 89.0 COG0152@1|root,COG0152@2|Bacteria 2|Bacteria F phosphoribosylaminoimidazolesuccinocarboxamide synthase activity purC GO:0003674,GO:0003824,GO:0004639,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006188,GO:0006189,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.2.6,6.3.4.13 ko:K01923,ko:K01945,ko:K03566 ko00230,ko01100,ko01110,ko01130,ko02026,map00230,map01100,map01110,map01130,map02026 M00048 R04144,R04591 RC00064,RC00090,RC00162,RC00166 ko00000,ko00001,ko00002,ko01000,ko03000 - - - SAICAR_synt k59_1402613_1 1088721.NSU_3761 1.27e-200 560.0 COG0620@1|root,COG0620@2|Bacteria,1MUI9@1224|Proteobacteria,2TTWK@28211|Alphaproteobacteria,2K0DU@204457|Sphingomonadales 204457|Sphingomonadales E Methionine synthase - - 2.1.1.14 ko:K00549 ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230 M00017 R04405,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 - - - Meth_synt_2 k59_1402613_2 1088721.NSU_3762 7.77e-33 116.0 COG5517@1|root,COG5517@2|Bacteria,1N7B2@1224|Proteobacteria,2UIGP@28211|Alphaproteobacteria,2K6NI@204457|Sphingomonadales 204457|Sphingomonadales Q Nuclear transport factor 2 (NTF2) domain - - - - - - - - - - - - SnoaL_4 k59_1183661_1 1121434.AULY01000009_gene2098 4.32e-10 61.2 COG0329@1|root,COG0329@2|Bacteria,1MUCM@1224|Proteobacteria,42M0X@68525|delta/epsilon subdivisions,2WK4D@28221|Deltaproteobacteria,2M7XK@213115|Desulfovibrionales 28221|Deltaproteobacteria E Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) dapA - 4.3.3.7 ko:K01714 ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R10147 RC03062,RC03063 ko00000,ko00001,ko00002,ko01000 - - - DHDPS k59_1183661_2 243159.AFE_2663 9.06e-63 205.0 COG0289@1|root,COG0289@2|Bacteria,1MUCT@1224|Proteobacteria,1RMCZ@1236|Gammaproteobacteria,2NC2S@225057|Acidithiobacillales 225057|Acidithiobacillales E Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate dapB - 1.17.1.8 ko:K00215 ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R04198,R04199 RC00478 ko00000,ko00001,ko00002,ko01000 - - - DapB_C,DapB_N k59_1183661_3 1206744.BAGL01000052_gene2408 1.95e-09 57.8 COG0174@1|root,COG0174@2|Bacteria,2GMN1@201174|Actinobacteria,4FTXQ@85025|Nocardiaceae 201174|Actinobacteria E Glutamine synthetase, beta-Grasp domain glnA GO:0001968,GO:0003674,GO:0003824,GO:0004356,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006541,GO:0006542,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009405,GO:0009605,GO:0009607,GO:0009893,GO:0009987,GO:0010468,GO:0010604,GO:0010628,GO:0010755,GO:0010756,GO:0010954,GO:0016020,GO:0016053,GO:0016211,GO:0016874,GO:0016879,GO:0016880,GO:0019222,GO:0019752,GO:0019899,GO:0020012,GO:0030162,GO:0030312,GO:0030682,GO:0031323,GO:0031325,GO:0032268,GO:0032270,GO:0035375,GO:0040007,GO:0043207,GO:0043436,GO:0044044,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044403,GO:0044413,GO:0044415,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0045862,GO:0046394,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0051701,GO:0051704,GO:0051707,GO:0051805,GO:0051807,GO:0051832,GO:0051834,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0060255,GO:0065007,GO:0070613,GO:0071704,GO:0071944,GO:0075136,GO:0080090,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1903317,GO:1903319 6.3.1.2 ko:K01915 ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 - R00253 RC00010,RC02798 ko00000,ko00001,ko01000,ko04147 - - - Gln-synt_C,Gln-synt_N k59_446966_1 1167006.UWK_00746 3.82e-08 55.8 COG0714@1|root,COG0714@2|Bacteria,1MUFN@1224|Proteobacteria,42NCX@68525|delta/epsilon subdivisions,2WJUZ@28221|Deltaproteobacteria,2MHQ8@213118|Desulfobacterales 28221|Deltaproteobacteria S PFAM ATPase family associated with various cellular activities (AAA) - - - ko:K03924 - - - - ko00000,ko01000 - - - AAA_3 k59_446966_2 521674.Plim_2318 1.45e-66 211.0 COG0854@1|root,COG0854@2|Bacteria,2IYJ4@203682|Planctomycetes 203682|Planctomycetes H Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate pdxJ GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008614,GO:0008615,GO:0009058,GO:0009110,GO:0009987,GO:0016740,GO:0016769,GO:0017144,GO:0018130,GO:0019438,GO:0033856,GO:0034641,GO:0042364,GO:0042816,GO:0042819,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072524,GO:0072525,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 2.6.99.2 ko:K03474 ko00750,ko01100,map00750,map01100 M00124 R05838 RC01476 ko00000,ko00001,ko00002,ko01000 - - - PdxJ k59_844244_1 1125863.JAFN01000001_gene36 9.68e-40 132.0 COG0236@1|root,COG0236@2|Bacteria,1MZ4P@1224|Proteobacteria,42V9M@68525|delta/epsilon subdivisions,2WRDW@28221|Deltaproteobacteria 28221|Deltaproteobacteria IQ Carrier of the growing fatty acid chain in fatty acid biosynthesis acpP GO:0000035,GO:0000036,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016053,GO:0019637,GO:0019752,GO:0019842,GO:0031177,GO:0032787,GO:0033218,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0044620,GO:0046394,GO:0046467,GO:0046493,GO:0048037,GO:0051192,GO:0071704,GO:0072330,GO:0072341,GO:0090407,GO:0140104,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 - ko:K02078 - - - - ko00000,ko00001 - - - PP-binding k59_844244_2 1121405.dsmv_2217 1.69e-07 51.6 COG1028@1|root,COG1028@2|Bacteria,1MU6X@1224|Proteobacteria,42MB9@68525|delta/epsilon subdivisions,2WJ64@28221|Deltaproteobacteria,2MJ4H@213118|Desulfobacterales 28221|Deltaproteobacteria IQ Short-chain dehydrogenase reductase SDR - - 1.1.1.100 ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 k59_1690881_1 477184.KYC_12188 2.07e-65 212.0 COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2VKM4@28216|Betaproteobacteria 28216|Betaproteobacteria C transferase - - - - - - - - - - - - CoA_transf_3 k59_446978_1 366602.Caul_0050 6.17e-15 80.1 COG1529@1|root,COG1529@2|Bacteria,1QTTJ@1224|Proteobacteria,2TQVK@28211|Alphaproteobacteria,2KFXR@204458|Caulobacterales 204458|Caulobacterales C Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain - - 1.3.99.16 ko:K07303 - - - - ko00000,ko01000 - - - Ald_Xan_dh_C2 k59_281404_1 472759.Nhal_3838 1.44e-55 189.0 COG0576@1|root,COG0811@1|root,COG0576@2|Bacteria,COG0811@2|Bacteria,1MX5J@1224|Proteobacteria,1S2ZN@1236|Gammaproteobacteria,1WZ7W@135613|Chromatiales 135613|Chromatiales U MotA TolQ ExbB proton channel - - - ko:K03561 - - - - ko00000,ko02000 1.A.30.2.1 - - MotA_ExbB k59_1183678_1 1238182.C882_1603 6.73e-58 193.0 COG2148@1|root,COG2148@2|Bacteria,1MV6W@1224|Proteobacteria,2TRZA@28211|Alphaproteobacteria,2JPR4@204441|Rhodospirillales 204441|Rhodospirillales M Bacterial sugar transferase - - - - - - - - - - - - Bac_transf k59_1183678_2 1122137.AQXF01000002_gene22 5.28e-09 60.1 COG0457@1|root,COG0457@2|Bacteria,1PDUB@1224|Proteobacteria,2TTYN@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Tetratricopeptide repeat - - - - - - - - - - - - TPR_16,TPR_19,TPR_21 k59_223337_1 1380600.AUYN01000010_gene888 2.51e-63 219.0 COG3291@1|root,COG4935@1|root,COG3291@2|Bacteria,COG4935@2|Bacteria,4NDZC@976|Bacteroidetes,1HY1V@117743|Flavobacteriia 976|Bacteroidetes DZ adhesin AidA-related - - - - - - - - - - - - CHU_C,PKD,SprB k59_784646_1 436308.Nmar_1055 6.96e-128 376.0 COG1530@1|root,arCOG00321@2157|Archaea,41T2C@651137|Thaumarchaeota 651137|Thaumarchaeota L modulator of DNA gyrase - - - ko:K03568 - - - - ko00000,ko01002 - - - PmbA_TldD k59_223345_1 316407.1799720 3.82e-129 370.0 COG3770@1|root,COG3770@2|Bacteria,1MU9I@1224|Proteobacteria,1RMJK@1236|Gammaproteobacteria,3XMNR@561|Escherichia 1236|Gammaproteobacteria M Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus mepA GO:0000270,GO:0003674,GO:0003824,GO:0004175,GO:0006022,GO:0006023,GO:0006024,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016787,GO:0019538,GO:0030203,GO:0034645,GO:0042221,GO:0042493,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0050896,GO:0070011,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0140096,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 - ko:K07261 - - - - ko00000,ko01000,ko01002,ko01011 - - iAPECO1_1312.APECO1_4236,iE2348C_1286.E2348C_2468,iECABU_c1320.ECABU_c26610,iECED1_1282.ECED1_2792,iECIAI39_1322.ECIAI39_2477,iECOK1_1307.ECOK1_2610,iECS88_1305.ECS88_2476,iEcSMS35_1347.EcSMS35_2485,iLF82_1304.LF82_1316,iNRG857_1313.NRG857_11790,iUMN146_1321.UM146_05170,iUTI89_1310.UTI89_C2613,ic_1306.c2874 Peptidase_M74 k59_1747857_1 926549.KI421517_gene2838 4.02e-28 113.0 COG2303@1|root,COG2303@2|Bacteria,4NEF2@976|Bacteroidetes,47JQ2@768503|Cytophagia 976|Bacteroidetes E PFAM glucose-methanol-choline oxidoreductase - - - - - - - - - - - - FAD_binding_2,GMC_oxred_C,GMC_oxred_N k59_166221_1 1500894.JQNN01000001_gene1125 4.47e-20 91.7 COG1232@1|root,COG1232@2|Bacteria,1NQUH@1224|Proteobacteria,2VJV1@28216|Betaproteobacteria,472Y4@75682|Oxalobacteraceae 28216|Betaproteobacteria H Flavin containing amine oxidoreductase hpnE - 1.17.8.1 ko:K21677 - - - - ko00000,ko01000 - - - Amino_oxidase k59_166221_2 85643.Tmz1t_2158 2.02e-66 210.0 COG1562@1|root,COG1562@2|Bacteria,1MX4W@1224|Proteobacteria,2VJ13@28216|Betaproteobacteria,2KUHC@206389|Rhodocyclales 206389|Rhodocyclales I Squalene synthase HpnD - - 2.5.1.32,2.5.1.99 ko:K02291 ko00906,ko01062,ko01100,ko01110,map00906,map01062,map01100,map01110 M00097 R02065,R04218,R07270,R10177 RC00362,RC01101,RC02869 ko00000,ko00001,ko00002,ko01000,ko01006 - - - SQS_PSY k59_1183712_1 314287.GB2207_04517 2.44e-82 258.0 COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,1RN9T@1236|Gammaproteobacteria,1J4K6@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O Belongs to the peptidase S1C family mucD GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005575,GO:0005623,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0016787,GO:0017171,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043170,GO:0044238,GO:0044464,GO:0070011,GO:0071704,GO:0140096,GO:1901564 3.4.21.107 ko:K04771 ko01503,ko02020,map01503,map02020 M00728 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 - - - PDZ_2,Trypsin_2 k59_55948_1 1144325.PMI22_00598 4.78e-73 234.0 COG5361@1|root,COG5361@2|Bacteria,1MWTW@1224|Proteobacteria,1S3FP@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Protein of unknown function (DUF1214) - - - - - - - - - - - - DUF1214,DUF1254 k59_111886_1 883077.HMPREF9241_01703 1.72e-39 139.0 COG5492@1|root,COG5492@2|Bacteria,2IK71@201174|Actinobacteria 201174|Actinobacteria N domain, Protein - - - - - - - - - - - - - k59_1294332_1 1379270.AUXF01000005_gene391 2.71e-45 155.0 COG0558@1|root,COG0558@2|Bacteria,1ZSXG@142182|Gemmatimonadetes 142182|Gemmatimonadetes I CDP-alcohol phosphatidyltransferase - - 2.7.8.5 ko:K00995 ko00564,ko01100,map00564,map01100 - R01801 RC00002,RC00017,RC02795 ko00000,ko00001,ko01000 - - - CDP-OH_P_transf k59_223373_1 1150469.RSPPHO_01892 4.52e-56 189.0 COG0263@1|root,COG0263@2|Bacteria,1MUBG@1224|Proteobacteria,2TRKB@28211|Alphaproteobacteria,2JPD3@204441|Rhodospirillales 204441|Rhodospirillales E Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate proB - 2.7.2.11 ko:K00931 ko00330,ko00332,ko01100,ko01130,ko01230,map00330,map00332,map01100,map01130,map01230 M00015 R00239 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase,PUA k59_502186_1 928724.SacglDRAFT_02964 6.46e-15 72.8 COG2386@1|root,COG2386@2|Bacteria,2HRH1@201174|Actinobacteria,4EAQG@85010|Pseudonocardiales 201174|Actinobacteria O CcmB protein - - - ko:K02194 ko02010,map02010 M00259 - - ko00000,ko00001,ko00002,ko02000 3.A.1.107 - - CcmB k59_673153_1 1410609.JHVB01000008_gene837 3.72e-08 62.8 COG0527@1|root,COG0527@2|Bacteria,2J6FK@203691|Spirochaetes 203691|Spirochaetes E Belongs to the aspartokinase family - - 2.7.2.4 ko:K00928 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00017,M00018,M00033,M00525,M00526,M00527 R00480 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase,ACT_7 k59_1635662_1 996637.SGM_6204 1.82e-88 278.0 COG0459@1|root,COG0459@2|Bacteria,2GKC9@201174|Actinobacteria 201174|Actinobacteria O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions groL2 GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0016465,GO:0032991,GO:0044183,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0051082,GO:0061077,GO:0101031,GO:1990220 - ko:K04077 ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 - - - Cpn60_TCP1 k59_1690934_1 2340.JV46_19820 5.97e-13 73.6 COG2172@1|root,COG2203@1|root,COG2208@1|root,COG2172@2|Bacteria,COG2203@2|Bacteria,COG2208@2|Bacteria,1MXJQ@1224|Proteobacteria,1RQIY@1236|Gammaproteobacteria,1JA7R@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T Sigma factor PP2C-like phosphatases - - 3.1.3.3 ko:K01079 ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230 M00020 R00582 RC00017 ko00000,ko00001,ko00002,ko01000,ko01009 - - - GAF,GAF_2,HATPase_c_2,PAS,SpoIIE k59_673161_1 525897.Dbac_3479 2.86e-55 201.0 COG0642@1|root,COG0784@1|root,COG5000@1|root,COG0784@2|Bacteria,COG2205@2|Bacteria,COG5000@2|Bacteria,1NRP8@1224|Proteobacteria,42M0Y@68525|delta/epsilon subdivisions,2WIR4@28221|Deltaproteobacteria,2M7T3@213115|Desulfovibrionales 28221|Deltaproteobacteria T histidine kinase A domain protein - - - - - - - - - - - - 5TM-5TMR_LYT,GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg,dCache_1 k59_1010698_1 441620.Mpop_2976 2.17e-29 115.0 COG0626@1|root,COG0626@2|Bacteria,1MU57@1224|Proteobacteria,2TW14@28211|Alphaproteobacteria,1JSD2@119045|Methylobacteriaceae 28211|Alphaproteobacteria E aromatic amino acid beta-eliminating lyase threonine aldolase metB - 2.5.1.48 ko:K01739 ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00270,map00450,map00920,map01100,map01110,map01130,map01230 M00017 R00999,R01288,R02508,R03217,R03260,R04944,R04945,R04946 RC00020,RC00056,RC00069,RC00420,RC02848,RC02866 ko00000,ko00001,ko00002,ko01000 - - - Cys_Met_Meta_PP k59_1747909_1 1123508.JH636456_gene119 1.32e-22 94.0 COG3335@1|root,COG3335@2|Bacteria,2J1BU@203682|Planctomycetes 203682|Planctomycetes L DDE superfamily endonuclease - - - - - - - - - - - - DDE_3 k59_502212_2 436308.Nmar_1492 1.17e-14 75.1 arCOG03272@1|root,arCOG03272@2157|Archaea 436308.Nmar_1492|- - - - - - - - - - - - - - - - k59_1125757_1 519989.ECTPHS_04334 1.39e-30 122.0 COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,1RMBS@1236|Gammaproteobacteria,1WX5F@135613|Chromatiales 135613|Chromatiales NU PFAM Type II secretion system protein E - - - ko:K02454 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - T2SSE,T2SSE_N k59_1748535_2 1123320.KB889561_gene4688 5.86e-25 102.0 COG3211@1|root,COG3211@2|Bacteria,2GJKE@201174|Actinobacteria 201174|Actinobacteria G Bacterial protein of unknown function (DUF839) - - - ko:K07093 - - - - ko00000 - - - DUF839,PD40 k59_1184313_1 1131814.JAFO01000001_gene2836 7.11e-98 299.0 COG5361@1|root,COG5361@2|Bacteria,1NX2A@1224|Proteobacteria,2TTBA@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Protein of unknown function (DUF1254) - - - - - - - - - - - - DUF1214,DUF1254 k59_558778_1 1122137.AQXF01000001_gene2607 1.36e-118 360.0 COG1629@1|root,COG4771@2|Bacteria,1MVFB@1224|Proteobacteria,2U2KS@28211|Alphaproteobacteria 28211|Alphaproteobacteria P TonB-dependent receptor plug - - - - - - - - - - - - Plug,TonB_dep_Rec k59_1184314_1 697282.Mettu_0212 3.36e-20 88.2 COG4103@1|root,COG4103@2|Bacteria,1N6YZ@1224|Proteobacteria,1SD1K@1236|Gammaproteobacteria,1XFGU@135618|Methylococcales 135618|Methylococcales S Tellurite resistance protein TerB - - - - - - - - - - - - TerB k59_1184314_2 395963.Bind_2498 9.08e-35 123.0 COG1853@1|root,COG1853@2|Bacteria,1NB1B@1224|Proteobacteria,2U5NM@28211|Alphaproteobacteria,3NB22@45404|Beijerinckiaceae 28211|Alphaproteobacteria S Flavin reductase like domain - - - - - - - - - - - - Flavin_Reduct k59_845062_1 448385.sce5871 1.42e-61 213.0 COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,1MV6G@1224|Proteobacteria,42NHZ@68525|delta/epsilon subdivisions,2WJ2H@28221|Deltaproteobacteria,2YX1T@29|Myxococcales 28221|Deltaproteobacteria H Methionine synthase metH - 2.1.1.13 ko:K00548 ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230 M00017 R00946,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 - - - B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans k59_1011333_1 400668.Mmwyl1_2519 1.97e-11 66.2 COG1643@1|root,COG1643@2|Bacteria,1MUEQ@1224|Proteobacteria,1RMU1@1236|Gammaproteobacteria,1XHUD@135619|Oceanospirillales 135619|Oceanospirillales L Involved in the post-transcriptional processing of the daa operon mRNA, which encodes proteins involved in fimbrial biogenesis of an enteropathogenic E. coli strain hrpA - 3.6.4.13 ko:K03578 - - - - ko00000,ko01000 - - - DEAD,DUF3418,HA2,Helicase_C,OB_NTP_bind k59_1240299_1 1229909.NSED_09495 1.14e-193 546.0 COG1509@1|root,arCOG03246@2157|Archaea,41SY6@651137|Thaumarchaeota 651137|Thaumarchaeota E TIGRFAM lysine 2,3-aminomutase YodO family protein - - - - - - - - - - - - - k59_447699_1 1229756.C269_04885 2.55e-35 129.0 COG1028@1|root,COG1028@2|Bacteria,1TPZ8@1239|Firmicutes,4HAMW@91061|Bacilli,4AX7E@81850|Leuconostocaceae 91061|Bacilli IQ KR domain kduD - 1.1.1.127 ko:K00065 ko00040,map00040 - R01542 RC00089 ko00000,ko00001,ko01000 - - - adh_short,adh_short_C2 k59_1748567_1 1120970.AUBZ01000002_gene798 1.11e-15 76.6 COG1200@1|root,COG1200@2|Bacteria,1MWN2@1224|Proteobacteria,1RMMQ@1236|Gammaproteobacteria,46544@72275|Alteromonadaceae 1236|Gammaproteobacteria L Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) recG GO:0003674,GO:0003678,GO:0003724,GO:0003824,GO:0004003,GO:0004004,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006807,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0008186,GO:0009314,GO:0009379,GO:0009628,GO:0009987,GO:0010501,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0032991,GO:0033202,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0051276,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:0140098,GO:1901360,GO:1902494 3.6.4.12 ko:K03655 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,Helicase_C,RecG_wedge k59_1748567_2 2340.JV46_16080 8.19e-20 88.2 COG3161@1|root,COG3161@2|Bacteria,1N8BF@1224|Proteobacteria,1SDX2@1236|Gammaproteobacteria,1J6IV@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway ubiC GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0008813,GO:0009058,GO:0009108,GO:0009987,GO:0016829,GO:0016830,GO:0016833,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901661,GO:1901663 4.1.3.40 ko:K03181 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00117 R01302 RC00491,RC02148 ko00000,ko00001,ko00002,ko01000 - - iZ_1308.Z5638 Chor_lyase k59_673846_1 1122135.KB893134_gene3712 7.45e-35 126.0 COG1434@1|root,COG1434@2|Bacteria,1RHMV@1224|Proteobacteria,2U957@28211|Alphaproteobacteria 28211|Alphaproteobacteria S DUF218 domain MA20_20455 - - - - - - - - - - - DUF218 k59_1636366_1 765914.ThisiDRAFT_2072 4.31e-18 89.0 COG3170@1|root,COG3170@2|Bacteria,1MXV7@1224|Proteobacteria,1RMM5@1236|Gammaproteobacteria,1WVVA@135613|Chromatiales 135613|Chromatiales NU FimV C-terminal - - - ko:K08086 - - - - ko00000 - - - TPR_19 k59_166971_1 1370121.AUWS01000045_gene1739 2.96e-82 265.0 COG0402@1|root,COG0402@2|Bacteria,2GZ2Q@201174|Actinobacteria,23EX5@1762|Mycobacteriaceae 201174|Actinobacteria F Amidohydrolase family hutF - - - - - - - - - - - Amidohydro_1 k59_1072868_1 1144305.PMI02_00721 6.12e-124 363.0 COG0820@1|root,COG0820@2|Bacteria,1MUYK@1224|Proteobacteria,2TQT3@28211|Alphaproteobacteria,2K0CT@204457|Sphingomonadales 204457|Sphingomonadales J Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs rlmN - 2.1.1.192 ko:K06941 - - - - ko00000,ko01000,ko03009 - - - Radical_SAM k59_502857_2 526225.Gobs_3467 3.46e-38 146.0 COG1020@1|root,COG1020@2|Bacteria,2HEFF@201174|Actinobacteria,4EUAJ@85013|Frankiales 201174|Actinobacteria Q Protein of unknown function (DUF1298) - - - - - - - - - - - - DUF1298,WES_acyltransf k59_1350951_1 1189619.pgond44_14073 6.5e-62 214.0 COG0642@1|root,COG4191@1|root,COG2205@2|Bacteria,COG4191@2|Bacteria,4NEJX@976|Bacteroidetes,1I0JH@117743|Flavobacteriia 976|Bacteroidetes T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - 7TMR-DISMED2,7TMR-DISM_7TM,HATPase_c,HisKA,TPR_12,TPR_7 k59_1691633_1 1005048.CFU_4378 8.75e-73 234.0 COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2VHGR@28216|Betaproteobacteria,472HD@75682|Oxalobacteraceae 28216|Betaproteobacteria C Belongs to the aldehyde dehydrogenase family gabD - 1.2.1.16,1.2.1.20,1.2.1.79 ko:K00135 ko00250,ko00310,ko00350,ko00650,ko00760,ko01100,ko01120,map00250,map00310,map00350,map00650,map00760,map01100,map01120 M00027 R00713,R00714,R02401 RC00080 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_112659_1 883067.HMPREF9237_00897 5.79e-58 192.0 COG0468@1|root,COG0468@2|Bacteria,2GJ4P@201174|Actinobacteria,4D3IF@85005|Actinomycetales 201174|Actinobacteria L Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage recA GO:0000150,GO:0000166,GO:0000287,GO:0000725,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0009314,GO:0009411,GO:0009416,GO:0009432,GO:0009605,GO:0009628,GO:0009650,GO:0009987,GO:0009991,GO:0016462,GO:0016787,GO:0016788,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0030145,GO:0030554,GO:0031668,GO:0032553,GO:0032555,GO:0032559,GO:0033554,GO:0034641,GO:0035639,GO:0036094,GO:0042148,GO:0042221,GO:0042623,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046677,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0090304,GO:0090305,GO:0097159,GO:0097367,GO:0140097,GO:1901265,GO:1901360,GO:1901363 - ko:K03553 ko03440,map03440 M00729 - - ko00000,ko00001,ko00002,ko03400 - - - RecA k59_447716_1 46429.BV95_01286 6.42e-18 81.3 COG0670@1|root,COG0670@2|Bacteria,1MU69@1224|Proteobacteria,2TRSF@28211|Alphaproteobacteria,2K14K@204457|Sphingomonadales 204457|Sphingomonadales S Belongs to the BI1 family - - - ko:K06890 - - - - ko00000 - - - Bax1-I k59_447716_2 1096930.L284_02220 2.35e-51 171.0 COG0345@1|root,COG0345@2|Bacteria,1R5J1@1224|Proteobacteria,2TTY7@28211|Alphaproteobacteria,2K353@204457|Sphingomonadales 204457|Sphingomonadales E Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline proC - 1.5.1.2 ko:K00286 ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230 M00015 R01248,R01251,R03291,R03293 RC00054,RC00083 ko00000,ko00001,ko00002,ko01000 - - - F420_oxidored,P5CR_dimer k59_1295084_1 316407.85675877 1.29e-88 260.0 COG2731@1|root,COG2731@2|Bacteria,1RGW2@1224|Proteobacteria,1S72G@1236|Gammaproteobacteria,3XPHG@561|Escherichia 1236|Gammaproteobacteria G Required for full activity of the EbgA enzyme. Exact function not known ebgC - - ko:K12112 ko00052,ko00511,ko01100,map00052,map00511,map01100 - R01678 RC00049 ko00000,ko00001 - - - DUF386 k59_1295084_2 199310.c3833 1.77e-35 133.0 COG3250@1|root,COG3250@2|Bacteria,1MVBN@1224|Proteobacteria,1RMER@1236|Gammaproteobacteria,3XN5C@561|Escherichia 1236|Gammaproteobacteria G lactose catabolic process ebgA GO:0003674,GO:0003824,GO:0004553,GO:0004565,GO:0005575,GO:0005975,GO:0005984,GO:0005988,GO:0005990,GO:0008150,GO:0008152,GO:0009056,GO:0009311,GO:0009313,GO:0009341,GO:0009987,GO:0015925,GO:0016052,GO:0016787,GO:0016798,GO:0032991,GO:0044237,GO:0044238,GO:0044248,GO:0044262,GO:0044275,GO:0046352,GO:0071704,GO:1901575,GO:1902494 3.2.1.23 ko:K01190,ko:K12111 ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100 - R01105,R01678,R03355,R04783,R06114 RC00049,RC00452 ko00000,ko00001,ko01000 - - iECNA114_1301.ECNA114_0327 Bgal_small_N,DUF4981,Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N k59_447734_1 1122137.AQXF01000004_gene1444 1.1e-83 248.0 COG5352@1|root,COG5352@2|Bacteria,1RHI6@1224|Proteobacteria,2TS7F@28211|Alphaproteobacteria 28211|Alphaproteobacteria S GcrA cell cycle regulator gcrA - - ko:K13583 ko04112,map04112 - - - ko00000,ko00001 - - - GcrA k59_673891_1 1266925.JHVX01000007_gene2376 2.1e-97 303.0 COG1185@1|root,COG1185@2|Bacteria,1MVB9@1224|Proteobacteria,2VI1P@28216|Betaproteobacteria,372MQ@32003|Nitrosomonadales 28216|Betaproteobacteria J Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction pnp - 2.7.7.8 ko:K00962 ko00230,ko00240,ko03018,map00230,map00240,map03018 M00394 R00437,R00438,R00439,R00440 RC02795 ko00000,ko00001,ko00002,ko01000,ko03016,ko03019 - - - KH_1,PNPase,RNase_PH,RNase_PH_C,S1 k59_558843_1 375286.mma_2075 3.58e-07 53.9 COG5495@1|root,COG5495@2|Bacteria,1RBEZ@1224|Proteobacteria,2VS2J@28216|Betaproteobacteria,472QF@75682|Oxalobacteraceae 28216|Betaproteobacteria S Domain of unknown function (DUF2520) - - - - - - - - - - - - DUF2520,Rossmann-like k59_558843_2 469383.Cwoe_2891 9.03e-55 181.0 COG0414@1|root,COG0414@2|Bacteria,2GJEQ@201174|Actinobacteria,4CPNC@84995|Rubrobacteria 84995|Rubrobacteria H Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate panC - 6.3.2.1 ko:K01918 ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110 M00119 R02473 RC00096,RC00141 ko00000,ko00001,ko00002,ko01000 - - - Pantoate_ligase k59_955970_3 1229909.NSED_09710 1.14e-26 98.6 COG5466@1|root,arCOG05278@2157|Archaea 2157|Archaea S small metal-binding protein - - - - - - - - - - - - DUF1059 k59_1801044_1 983920.Y88_2753 1.27e-75 233.0 COG1969@1|root,COG1969@2|Bacteria,1MU87@1224|Proteobacteria,2TSH2@28211|Alphaproteobacteria 28211|Alphaproteobacteria C Ni Fe-hydrogenase, b-type cytochrome subunit hupC GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K03620 ko02020,map02020 - - - ko00000,ko00001 - - - Ni_hydr_CYTB k59_224135_2 469378.Ccur_06230 2.66e-07 53.5 COG0349@1|root,COG0349@2|Bacteria,2GKNM@201174|Actinobacteria,4CV2Q@84998|Coriobacteriia 84998|Coriobacteriia J Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides rnd - 3.1.13.5 ko:K03684 - - - - ko00000,ko01000,ko03016 - - - DNA_pol_A_exo1,HRDC k59_673901_1 1121015.N789_12665 2.12e-54 193.0 COG4447@1|root,COG4447@2|Bacteria,1NRDC@1224|Proteobacteria,1S0E3@1236|Gammaproteobacteria,1X7BC@135614|Xanthomonadales 135614|Xanthomonadales S cellulose binding - - - - - - - - - - - - - k59_1801046_1 436308.Nmar_0253 6.57e-152 430.0 COG1018@1|root,arCOG02200@2157|Archaea,41S72@651137|Thaumarchaeota 651137|Thaumarchaeota C oxidoreductase FAD NAD(P)-binding - - 1.18.1.2,1.19.1.1 ko:K00528 - - R10159 - ko00000,ko01000 - - - FAD_binding_6,NAD_binding_1 k59_1801046_2 436308.Nmar_0254 9.29e-28 109.0 COG1413@1|root,arCOG02970@2157|Archaea 2157|Archaea C HEAT repeat - - - - - - - - - - - - HEAT_2,HEAT_PBS k59_1072939_1 1121022.ABENE_01265 2.01e-40 148.0 COG1448@1|root,COG1448@2|Bacteria,1MUT0@1224|Proteobacteria,2TS9C@28211|Alphaproteobacteria,2KIGJ@204458|Caulobacterales 204458|Caulobacterales E Aminotransferase - - 2.6.1.57 ko:K00832 ko00270,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01230,map00270,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01230 M00024,M00025,M00034,M00040 R00694,R00734,R01731,R07396,R10845 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 k59_1072939_2 158190.SpiGrapes_1767 0.000273 42.7 COG1893@1|root,COG1893@2|Bacteria,2J64S@203691|Spirochaetes 203691|Spirochaetes H Ketopantoate reductase - - 1.1.1.169 ko:K00077 ko00770,ko01100,ko01110,map00770,map01100,map01110 M00119 R02472 RC00726 ko00000,ko00001,ko00002,ko01000 - - - ApbA k59_955991_2 204669.Acid345_3538 2.79e-106 322.0 COG1702@1|root,COG1702@2|Bacteria,3Y3RM@57723|Acidobacteria,2JI4V@204432|Acidobacteriia 204432|Acidobacteriia T PhoH-like protein - - - ko:K06217 - - - - ko00000 - - - PhoH k59_1072945_1 526227.Mesil_2226 9.51e-27 108.0 COG0169@1|root,COG0169@2|Bacteria,1WIM8@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus E Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA) aroE GO:0000166,GO:0003674,GO:0005488,GO:0036094,GO:0048037,GO:0050661,GO:0050662,GO:0097159,GO:1901265,GO:1901363 1.1.1.25 ko:K00014 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02413 RC00206 ko00000,ko00001,ko00002,ko01000 - - - Shikimate_DH,Shikimate_dh_N k59_673911_1 946077.W5A_00055 4.52e-09 56.6 COG0209@1|root,COG0209@2|Bacteria,4NEHQ@976|Bacteroidetes,1HXHB@117743|Flavobacteriia 976|Bacteroidetes F Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides nrdA - 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - ATP-cone,Ribonuc_red_lgC,Ribonuc_red_lgN k59_673911_2 391603.FBALC1_15597 1.04e-53 187.0 COG0306@1|root,COG0306@2|Bacteria,4NFCB@976|Bacteroidetes,1HYA8@117743|Flavobacteriia 976|Bacteroidetes U phosphate transporter - - - - - - - - - - - - PHO4 k59_1240359_1 1349767.GJA_5372 3.32e-26 106.0 COG3913@1|root,COG3913@2|Bacteria,1N01G@1224|Proteobacteria,2VUP0@28216|Betaproteobacteria 28216|Betaproteobacteria S TIGRFAM type VI secretion-associated protein, BMA_A0400 family - - - ko:K11890 ko02025,map02025 - - - ko00000,ko00001,ko02044 - - - DUF2094 k59_673916_1 107636.JQNK01000008_gene4093 1.39e-13 68.2 COG3212@1|root,COG3212@2|Bacteria,1NHDB@1224|Proteobacteria,2V0F9@28211|Alphaproteobacteria,370ZE@31993|Methylocystaceae 28211|Alphaproteobacteria S Peptidase propeptide and YPEB domain - - - - - - - - - - - - PepSY k59_673916_2 460265.Mnod_6194 2.85e-99 294.0 COG0745@1|root,COG0745@2|Bacteria,1N0YI@1224|Proteobacteria,2TSV8@28211|Alphaproteobacteria,1JRD4@119045|Methylobacteriaceae 28211|Alphaproteobacteria T PFAM response regulator receiver ctrA - - ko:K02483 - - - - ko00000,ko02022 - - - Response_reg,Trans_reg_C k59_673916_3 1333998.M2A_1655 7.5e-07 53.1 COG0642@1|root,COG0642@2|Bacteria,1MX6R@1224|Proteobacteria,2TS9N@28211|Alphaproteobacteria,4BQ1X@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria T His Kinase A (phosphoacceptor) domain feuQ - - - - - - - - - - - 2CSK_N,HATPase_c k59_1251307_1 649747.HMPREF0083_05196 4.26e-72 229.0 COG3185@1|root,COG3185@2|Bacteria,1UZP2@1239|Firmicutes,4HDQI@91061|Bacilli,26VND@186822|Paenibacillaceae 91061|Bacilli E Hydroxyphenylpyruvate dioxygenase, HPPD, N-terminal - - 1.13.11.27 ko:K00457 ko00130,ko00350,ko00360,ko01100,map00130,map00350,map00360,map01100 M00044 R01372,R02521 RC00505,RC00738 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Glyoxalase,Glyoxalase_5 k59_1251307_2 1068980.ARVW01000001_gene3483 8.12e-38 136.0 COG1912@1|root,COG1912@2|Bacteria,2IASJ@201174|Actinobacteria,4E3VM@85010|Pseudonocardiales 201174|Actinobacteria S S-adenosyl-l-methionine hydroxide adenosyltransferase - - - ko:K22205 - - - - ko00000,ko01000 - - - SAM_adeno_trans k59_1251308_1 641526.ADIWIN_1168 2.75e-180 535.0 COG1629@1|root,COG4771@2|Bacteria,4P1Z5@976|Bacteroidetes,1I04A@117743|Flavobacteriia 976|Bacteroidetes P Outer membrane receptor susC - - ko:K21573 - - - - ko00000,ko02000 1.B.14.6.1 - - CarbopepD_reg_2,Plug,TonB_dep_Rec k59_1307883_1 1353276.JADR01000005_gene2496 4.64e-110 323.0 COG2070@1|root,COG2070@2|Bacteria,4NF8Z@976|Bacteroidetes,1HYHD@117743|Flavobacteriia 976|Bacteroidetes S 2-nitropropane dioxygenase fabK - 1.3.1.9 ko:K02371 ko00061,ko01100,ko01212,map00061,map01100,map01212 M00083 R04429,R04724,R04955,R04958,R04961,R04966,R04969,R07765 RC00052,RC00076 ko00000,ko00001,ko00002,ko01000,ko01004 - - - NMO k59_742912_1 1229909.NSED_03210 3.46e-26 105.0 arCOG08741@1|root,arCOG08741@2157|Archaea,41SWQ@651137|Thaumarchaeota 651137|Thaumarchaeota E CAAX protease self-immunity - - - - - - - - - - - - Abi k59_742912_2 1229909.NSED_03215 5.97e-170 478.0 COG1405@1|root,arCOG01981@2157|Archaea,41SXZ@651137|Thaumarchaeota 651137|Thaumarchaeota K Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB) - - - ko:K03124 ko03022,ko05169,ko05203,map03022,map05169,map05203 - - - ko00000,ko00001,ko03021 - - - TFIIB,TF_Zn_Ribbon k59_1251324_1 316407.85675273 1.01e-201 558.0 COG0648@1|root,COG0648@2|Bacteria,1MX4Y@1224|Proteobacteria,1RQ60@1236|Gammaproteobacteria,3XNSH@561|Escherichia 1236|Gammaproteobacteria L Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin nfo GO:0000726,GO:0003674,GO:0003824,GO:0003906,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008081,GO:0008150,GO:0008152,GO:0008833,GO:0009987,GO:0016787,GO:0016788,GO:0016888,GO:0016893,GO:0033554,GO:0034641,GO:0042578,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360 3.1.21.2 ko:K01151 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - AP_endonuc_2 k59_629677_2 1229909.NSED_07115 2.07e-36 139.0 COG2132@1|root,COG3391@1|root,COG3794@1|root,arCOG02562@2157|Archaea,arCOG02926@2157|Archaea,arCOG03914@2157|Archaea 2157|Archaea Q Multicopper - - - - - - - - - - - - Lactonase k59_856220_1 706587.Desti_0974 3.54e-12 63.9 2BWQN@1|root,347D7@2|Bacteria,1P0PN@1224|Proteobacteria,431R8@68525|delta/epsilon subdivisions,2WW8A@28221|Deltaproteobacteria 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_856220_2 1121929.KB898666_gene2416 1.9e-26 101.0 COG4818@1|root,COG4818@2|Bacteria,1VBIZ@1239|Firmicutes,4HKBZ@91061|Bacilli 91061|Bacilli S membrane - - - - - - - - - - - - DUF4870 k59_912428_1 580340.Tlie_0532 4.73e-11 63.2 COG1206@1|root,COG1206@2|Bacteria,3TANY@508458|Synergistetes 508458|Synergistetes J Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs trmFO - 2.1.1.74 ko:K04094 - - - - ko00000,ko01000,ko03016,ko03036 - - - GIDA k59_912428_2 1185766.DL1_06235 4.94e-27 112.0 COG0758@1|root,COG0758@2|Bacteria,1MVF6@1224|Proteobacteria,2TRQE@28211|Alphaproteobacteria,2XKR6@285107|Thioclava 28211|Alphaproteobacteria LU DNA recombination-mediator protein A dprA - - ko:K04096 - - - - ko00000 - - - DNA_processg_A k59_857243_1 795666.MW7_1224 1.49e-16 79.7 COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2VJBE@28216|Betaproteobacteria 28216|Betaproteobacteria S protein conserved in bacteria - - - - - - - - - - - - TctC k59_857243_2 977880.RALTA_A0669 3.23e-93 290.0 COG0318@1|root,COG0318@2|Bacteria,1MWSD@1224|Proteobacteria,2VJYZ@28216|Betaproteobacteria,1KGJ3@119060|Burkholderiaceae 28216|Betaproteobacteria IQ AMP-binding enzyme C-terminal domain - - 6.2.1.48 ko:K02182 - - - - ko00000,ko01000 - - - AMP-binding,AMP-binding_C k59_969432_1 1121430.JMLG01000018_gene243 1.27e-91 286.0 COG1053@1|root,COG1053@2|Bacteria,1TPAR@1239|Firmicutes,247SY@186801|Clostridia,2616M@186807|Peptococcaceae 186801|Clostridia C TIGRFAM succinate dehydrogenase or fumarate reductase, flavoprotein sdhA - 1.3.5.1,1.3.5.4 ko:K00239,ko:K00244 ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,ko05134,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020,map05134 M00009,M00011,M00149,M00150,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,Succ_DH_flav_C k59_1082763_1 199310.c3208 4.1e-123 361.0 COG0579@1|root,COG0579@2|Bacteria,1N0QB@1224|Proteobacteria,1RN24@1236|Gammaproteobacteria,3XPBR@561|Escherichia 1236|Gammaproteobacteria C L-2-hydroxyglutarate oxidase LhgO lhgO GO:0000166,GO:0003674,GO:0003824,GO:0003973,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016614,GO:0016899,GO:0034419,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0048037,GO:0050660,GO:0050662,GO:0055114,GO:0071944,GO:0097159,GO:1901265,GO:1901363 - ko:K15736 - - - - ko00000,ko01000 - - - DAO k59_857246_1 498211.CJA_2655 1.29e-80 254.0 COG0464@1|root,COG0464@2|Bacteria,1MW4T@1224|Proteobacteria,1RPUI@1236|Gammaproteobacteria,1FGMK@10|Cellvibrio 1236|Gammaproteobacteria O ATPase family associated with various cellular activities (AAA) - - - - - - - - - - - - AAA k59_348789_1 1122137.AQXF01000007_gene3523 2.92e-24 98.2 COG0834@1|root,COG0834@2|Bacteria,1NE7N@1224|Proteobacteria 1224|Proteobacteria ET Bacterial extracellular solute-binding proteins, family 3 - - - - - - - - - - - - SBP_bac_3 k59_348789_2 1122137.AQXF01000007_gene3524 2.94e-98 289.0 COG0479@1|root,COG0479@2|Bacteria,1MVHS@1224|Proteobacteria,2TQYF@28211|Alphaproteobacteria 28211|Alphaproteobacteria C Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family sdhB - 1.3.5.1,1.3.5.4 ko:K00240 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00149,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 - - - Fer2_3,Fer4_10,Fer4_17,Fer4_8 k59_9757_1 1229909.NSED_00595 2.82e-118 344.0 COG0368@1|root,arCOG04338@2157|Archaea,41SI6@651137|Thaumarchaeota 651137|Thaumarchaeota H Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate cobS - 2.7.8.26 ko:K02233 ko00860,ko01100,map00860,map01100 M00122 R05223,R11174 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - CobS k59_1760652_1 566466.NOR53_1535 9.72e-109 318.0 COG0714@1|root,COG0714@2|Bacteria,1MV5I@1224|Proteobacteria,1RQ62@1236|Gammaproteobacteria,1J7IB@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S COG0714 MoxR-like ATPases HA62_21050 - - - - - - - - - - - AAA,AAA_5 k59_574152_1 743299.Acife_0160 3.42e-13 67.0 COG1451@1|root,COG1451@2|Bacteria,1MXZU@1224|Proteobacteria,1S9E4@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Metal-dependent hydrolase - - - ko:K07043 - - - - ko00000 - - - DUF45 k59_574152_2 743299.Acife_0161 1.03e-84 276.0 COG0610@1|root,COG0610@2|Bacteria,1MU96@1224|Proteobacteria,1RP2Q@1236|Gammaproteobacteria,2NCAX@225057|Acidithiobacillales 225057|Acidithiobacillales V Subunit R is required for both nuclease and ATPase activities, but not for modification - - 3.1.21.3 ko:K01153 - - - - ko00000,ko01000,ko02048 - - - HSDR_N,ResIII k59_1421396_1 357808.RoseRS_2126 8.11e-20 84.7 COG0346@1|root,COG0346@2|Bacteria,2G8UR@200795|Chloroflexi,377NI@32061|Chloroflexia 32061|Chloroflexia E PFAM Glyoxalase bleomycin resistance protein dioxygenase - - - - - - - - - - - - Glyoxalase k59_1421396_2 521096.Tpau_2851 4.59e-18 85.9 COG0008@1|root,COG0008@2|Bacteria,2GJJS@201174|Actinobacteria 201174|Actinobacteria J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) gltX GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 6.1.1.17 ko:K01885 ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120 M00121,M00359,M00360 R05578 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016 - - iNJ661.Rv2992c tRNA-synt_1c k59_235140_1 1120983.KB894571_gene2135 3.12e-107 315.0 COG0684@1|root,COG0684@2|Bacteria,1MW9P@1224|Proteobacteria,2TTGT@28211|Alphaproteobacteria,1JPPD@119043|Rhodobiaceae 28211|Alphaproteobacteria H Aldolase/RraA ligK - 4.1.3.17 ko:K02553,ko:K10218 ko00362,ko00660,ko01120,map00362,map00660,map01120 - R00008,R00350 RC00067,RC00502,RC01205 ko00000,ko00001,ko01000,ko03019 - - - RraA-like k59_235140_2 1172181.KB911703_gene145 7.54e-45 155.0 COG2828@1|root,COG2828@2|Bacteria,2GJF3@201174|Actinobacteria 201174|Actinobacteria S PrpF protein - - 5.3.2.8 ko:K16514 ko00362,ko01120,map00362,map01120 - R07839 RC02426 ko00000,ko00001,ko01000 - - - PrpF k59_1760663_1 312284.A20C1_10530 6.11e-223 621.0 COG4952@1|root,COG4952@2|Bacteria,2GK1Z@201174|Actinobacteria 201174|Actinobacteria M Isomerase rhaI - 5.3.1.14 ko:K01820 ko00040,ko00051,ko01120,map00040,map00051,map01120 - R01906,R02437,R06589 RC00376,RC00434,RC00516 ko00000,ko00001,ko01000 - - - AP_endonuc_2,RhaA k59_800859_1 1122135.KB893134_gene3649 7.59e-45 166.0 COG4166@1|root,COG4166@2|Bacteria,1MUVU@1224|Proteobacteria,2TQJX@28211|Alphaproteobacteria 28211|Alphaproteobacteria E ABC-type oligopeptide transport system periplasmic component yejA - - ko:K13893 ko02010,map02010 M00349 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5.21,3.A.1.5.24 - - SBP_bac_5 k59_800859_2 349124.Hhal_0596 4.36e-83 258.0 COG4174@1|root,COG4174@2|Bacteria,1MVKE@1224|Proteobacteria,1RMH8@1236|Gammaproteobacteria,1X292@135613|Chromatiales 135613|Chromatiales P binding-protein-dependent transport systems inner membrane component - - - ko:K13894 ko02010,map02010 M00349 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5.21,3.A.1.5.24 - - BPD_transp_1 k59_461283_1 1229909.NSED_00230 3.46e-38 131.0 arCOG10515@1|root,arCOG10515@2157|Archaea,41TAP@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1704047_1 1121898.Q766_04770 1.27e-53 179.0 COG2204@1|root,COG2204@2|Bacteria,4NDWI@976|Bacteroidetes,1HXHS@117743|Flavobacteriia,2NUNY@237|Flavobacterium 976|Bacteroidetes K ATPase (AAA fhlA - - - - - - - - - - - HTH_8,Sigma54_activat k59_1704047_2 886377.Murru_0850 7.18e-51 174.0 COG0621@1|root,COG0621@2|Bacteria,4NDU6@976|Bacteroidetes,1HX6T@117743|Flavobacteriia 976|Bacteroidetes J Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine miaB - 2.8.4.3 ko:K06168 - - R10645,R10646,R10647 RC00003,RC00980,RC03221,RC03222 ko00000,ko01000,ko03016 - - - Radical_SAM,TRAM,UPF0004 k59_122740_2 1123366.TH3_14754 6.03e-35 142.0 COG4254@1|root,COG4254@2|Bacteria,1N739@1224|Proteobacteria,2UFJF@28211|Alphaproteobacteria,2JU3N@204441|Rhodospirillales 204441|Rhodospirillales S FecR protein - - - - - - - - - - - - FecR k59_857305_1 1122137.AQXF01000003_gene2289 6.39e-111 328.0 COG0472@1|root,COG0472@2|Bacteria,1MUTK@1224|Proteobacteria,2TRUG@28211|Alphaproteobacteria 28211|Alphaproteobacteria M First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan mraY - 2.7.8.13 ko:K01000 ko00550,ko01100,ko01502,map00550,map01100,map01502 - R05629,R05630 RC00002,RC02753 ko00000,ko00001,ko01000,ko01011 9.B.146 - - Glycos_transf_4,MraY_sig1 k59_1478790_1 436308.Nmar_1066 1.05e-37 137.0 COG0017@1|root,arCOG00406@2157|Archaea,41S93@651137|Thaumarchaeota 651137|Thaumarchaeota J Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp) - - - - - - - - - - - - tRNA-synt_2,tRNA_anti-codon k59_1478790_2 436308.Nmar_1065 7.05e-81 243.0 COG0195@1|root,arCOG01761@2157|Archaea,41T4Q@651137|Thaumarchaeota 651137|Thaumarchaeota K Transcription elongation factor - - - - - - - - - - - - - k59_1704052_1 867845.KI911784_gene3678 2.16e-41 152.0 COG0653@1|root,COG0653@2|Bacteria,2G603@200795|Chloroflexi,374YG@32061|Chloroflexia 32061|Chloroflexia U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane secA GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680 - ko:K03070 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4 - - SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW k59_1195750_1 1096930.L284_15085 2e-89 266.0 COG2941@1|root,COG2941@2|Bacteria,1RAK4@1224|Proteobacteria,2U85I@28211|Alphaproteobacteria,2K46W@204457|Sphingomonadales 204457|Sphingomonadales H Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol coq7 - - ko:K06134 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00128 R04984,R08775 RC01254 ko00000,ko00001,ko00002,ko01000 - - - COQ7 k59_9790_1 876044.IMCC3088_164 1.06e-69 211.0 COG1592@1|root,COG1592@2|Bacteria,1R9WG@1224|Proteobacteria,1S25G@1236|Gammaproteobacteria,1J92R@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Rubrerythrin - - - - - - - - - - - - Rubrerythrin k59_1421436_1 1122137.AQXF01000002_gene303 1.85e-103 322.0 COG0855@1|root,COG0855@2|Bacteria,1MUM3@1224|Proteobacteria,2TRBP@28211|Alphaproteobacteria 28211|Alphaproteobacteria P Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) ppk - 2.7.4.1 ko:K00937 ko00190,ko03018,map00190,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - PP_kinase,PP_kinase_C,PP_kinase_N k59_1478796_1 1260251.SPISAL_06715 2.03e-29 119.0 COG0728@1|root,COG0728@2|Bacteria,1MUH0@1224|Proteobacteria,1RMXX@1236|Gammaproteobacteria,1WWAE@135613|Chromatiales 135613|Chromatiales S Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane murJ - - ko:K03980 - - - - ko00000,ko01011,ko02000 2.A.66.4 - - MVIN k59_1195752_2 926569.ANT_31550 2.02e-17 77.4 COG0242@1|root,COG0242@2|Bacteria,2G6VE@200795|Chloroflexi 200795|Chloroflexi J Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions def GO:0003674,GO:0003824,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016810,GO:0016811,GO:0018193,GO:0018206,GO:0019538,GO:0031365,GO:0036211,GO:0042586,GO:0043170,GO:0043412,GO:0043686,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0071704,GO:1901564 3.5.1.88 ko:K01462 - - - - ko00000,ko01000 - - - Pep_deformylase k59_178806_1 225937.HP15_2954 2.07e-84 266.0 COG3046@1|root,COG3046@2|Bacteria,1MUHX@1224|Proteobacteria,1RNUM@1236|Gammaproteobacteria,465DZ@72275|Alteromonadaceae 1236|Gammaproteobacteria S protein related to deoxyribodipyrimidine photolyase - - - ko:K06876 - - - - ko00000 - - - DPRP k59_1421439_1 1026882.MAMP_01989 2.86e-62 213.0 COG0025@1|root,COG0025@2|Bacteria,1QTUE@1224|Proteobacteria,1T1HJ@1236|Gammaproteobacteria,45ZN4@72273|Thiotrichales 72273|Thiotrichales P Sodium/hydrogen exchanger family - - - ko:K03316 - - - - ko00000 2.A.36 - - Na_H_Exchanger,TrkA_N k59_1760705_1 65393.PCC7424_4599 4.07e-64 211.0 COG0615@1|root,COG0615@2|Bacteria,1G8ZG@1117|Cyanobacteria,3KIXP@43988|Cyanothece 1117|Cyanobacteria IM Sulfotransferase family - - - - - - - - - - - - Sulfotransfer_3 k59_913383_1 1235457.C404_11460 1.62e-18 80.5 COG2963@1|root,COG2963@2|Bacteria,1N2T5@1224|Proteobacteria,2WENN@28216|Betaproteobacteria,1KHYE@119060|Burkholderiaceae 28216|Betaproteobacteria L Transposase - - - ko:K07483 - - - - ko00000 - - - HTH_Tnp_1 k59_913383_2 937777.Deipe_3510 2.48e-83 259.0 COG2801@1|root,COG2801@2|Bacteria 2|Bacteria L transposition - - - - - - - - - - - - HTH_21,rve k59_1760712_1 436308.Nmar_0507 7.26e-67 208.0 COG1418@1|root,arCOG01860@2157|Archaea,41T2N@651137|Thaumarchaeota 651137|Thaumarchaeota S Metal dependent phosphohydrolases with conserved 'HD' motif. - - - ko:K06950 - - - - ko00000 - - - HD k59_1195768_1 395019.Bmul_4677 3.62e-06 47.8 COG0220@1|root,COG0220@2|Bacteria,1QTX5@1224|Proteobacteria,2VZVN@28216|Betaproteobacteria,1KFMI@119060|Burkholderiaceae 28216|Betaproteobacteria J Protein of unknown function (DUF938) - - - - - - - - - - - - DUF938 k59_1195768_2 1380394.JADL01000012_gene1028 6.76e-31 124.0 COG2271@1|root,COG2271@2|Bacteria,1QXP5@1224|Proteobacteria,2TXP1@28211|Alphaproteobacteria,2JZ66@204441|Rhodospirillales 204441|Rhodospirillales G Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 k59_1590887_1 1229909.NSED_07455 3.02e-09 55.1 COG1846@1|root,arCOG03748@2157|Archaea 2157|Archaea K RNA secondary structure unwinding - - - - - - - - - - - - HTH_45,MarR_2,TrmB k59_1590887_2 1229909.NSED_07460 1.73e-81 250.0 COG0330@1|root,arCOG01915@2157|Archaea,41SYP@651137|Thaumarchaeota 651137|Thaumarchaeota O PFAM SPFH domain Band 7 family - - - - - - - - - - - - Band_7 k59_292447_1 1229909.NSED_06220 6.61e-40 136.0 COG0195@1|root,arCOG01761@2157|Archaea,41T4Q@651137|Thaumarchaeota 651137|Thaumarchaeota K Transcription elongation factor - - - - - - - - - - - - - k59_292447_2 436308.Nmar_1064 8.12e-55 180.0 COG0444@1|root,arCOG00181@2157|Archaea,41S9V@651137|Thaumarchaeota 651137|Thaumarchaeota E Oligopeptide/dipeptide transporter, C-terminal region - - - ko:K02031 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - ABC_tran,oligo_HPY k59_122761_1 382464.ABSI01000005_gene962 5.32e-62 202.0 COG3259@1|root,COG3259@2|Bacteria,46STG@74201|Verrucomicrobia 74201|Verrucomicrobia C Nickel-dependent hydrogenase frhA - 1.8.98.5 ko:K14126 ko00680,map00680 - R00019,R11943 RC00011 ko00000,ko00001,ko01000 - - - NiFeSe_Hases k59_122761_2 298655.KI912266_gene2855 1.78e-109 326.0 COG1941@1|root,COG1941@2|Bacteria,2GSPN@201174|Actinobacteria,4EU21@85013|Frankiales 201174|Actinobacteria C NADH ubiquinone oxidoreductase, 20 Kd subunit - - 1.12.1.2 ko:K18007 - - - - ko00000,ko01000 - - - Oxidored_q6 k59_574231_1 498761.HM1_2182 5.03e-57 192.0 COG0541@1|root,COG0541@2|Bacteria,1TP06@1239|Firmicutes,248EU@186801|Clostridia 186801|Clostridia U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY ffh - 3.6.5.4 ko:K03106 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko01000,ko02044 3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9 - - SRP54,SRP54_N,SRP_SPB k59_1421461_1 1158292.JPOE01000002_gene3685 1.09e-101 310.0 COG3666@1|root,COG3666@2|Bacteria,1N3QR@1224|Proteobacteria,2VK6J@28216|Betaproteobacteria,1KMID@119065|unclassified Burkholderiales 28216|Betaproteobacteria L Transposase DDE domain - - - - - - - - - - - - DDE_Tnp_1,DDE_Tnp_1_6,DUF772 k59_630777_2 436308.Nmar_1753 1.44e-31 121.0 arCOG08764@1|root,arCOG08764@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_1421465_1 243233.MCA0386 4.5e-14 72.0 COG1514@1|root,COG1514@2|Bacteria,1RDB2@1224|Proteobacteria,1SCZX@1236|Gammaproteobacteria,1XFHW@135618|Methylococcales 135618|Methylococcales J Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester - - 3.1.4.58 ko:K01975 - - - - ko00000,ko01000,ko03016 - - - LigT_PEase k59_1421465_2 292415.Tbd_2197 1.09e-41 146.0 COG0468@1|root,COG0468@2|Bacteria,1MU3C@1224|Proteobacteria,2VHNA@28216|Betaproteobacteria,1KRHR@119069|Hydrogenophilales 119069|Hydrogenophilales L Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage recA - - ko:K03553 ko03440,map03440 M00729 - - ko00000,ko00001,ko00002,ko03400 - - - RecA k59_743978_1 316407.1736572 3.6e-14 70.9 COG0322@1|root,COG0322@2|Bacteria,1MV38@1224|Proteobacteria,1RNGV@1236|Gammaproteobacteria,3XNGD@561|Escherichia 1236|Gammaproteobacteria L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision uvrC GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009314,GO:0009380,GO:0009381,GO:0009628,GO:0009987,GO:0016787,GO:0016788,GO:0032991,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1902494,GO:1905347,GO:1905348,GO:1990391 - ko:K03703 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - GIY-YIG,HHH,HHH_2,HHH_5,UVR,UvrC_HhH_N k59_743978_2 316407.1736573 3.98e-148 417.0 COG2197@1|root,COG2197@2|Bacteria,1MWGM@1224|Proteobacteria,1RQ1J@1236|Gammaproteobacteria,3XN63@561|Escherichia 1236|Gammaproteobacteria K Member of the two-component regulatory system UvrY BarA involved in the regulation of carbon metabolism via the CsrA CsrB regulatory system. UvrY activates the transcription of the untranslated csrB RNA and of barA, in an autoregulatory loop. Mediates the effects of CsrA on csrB RNA by BarA-dependent and BarA-independent mechanisms uvrY GO:0000156,GO:0000160,GO:0003674,GO:0007154,GO:0007165,GO:0008150,GO:0009987,GO:0023052,GO:0035556,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0060089,GO:0065007 - ko:K07689 ko02020,ko02025,ko02026,ko05111,map02020,map02025,map02026,map05111 M00475 - - ko00000,ko00001,ko00002,ko02022 - - - GerE,Response_reg k59_1647978_2 1278073.MYSTI_07874 6.38e-19 91.3 COG3391@1|root,COG3391@2|Bacteria,1R66T@1224|Proteobacteria,439FZ@68525|delta/epsilon subdivisions,2X4RS@28221|Deltaproteobacteria,2YZGC@29|Myxococcales 28221|Deltaproteobacteria G 6-phosphogluconolactonase activity - - - - - - - - - - - - - k59_687295_1 398527.Bphyt_1431 1.21e-107 318.0 COG0435@1|root,COG0435@2|Bacteria,1MV50@1224|Proteobacteria,2VKYJ@28216|Betaproteobacteria,1K3XV@119060|Burkholderiaceae 28216|Betaproteobacteria O Glutathione S-transferase, C-terminal domain - - 1.8.5.7 ko:K07393 - - - - ko00000,ko01000 - - - GST_C_2,GST_N_2 k59_913411_1 258533.BN977_02490 1.13e-16 82.0 COG0121@1|root,COG0121@2|Bacteria,2GXCD@201174|Actinobacteria,232FG@1762|Mycobacteriaceae 201174|Actinobacteria S Catalyzes the hydrolysis of the gamma-glutamyl amide bond of hercynyl-gamma-L-glutamyl-L-cysteine sulfoxide to produce hercynylcysteine sulfoxide, a step in the biosynthesis pathway of ergothioneine egtC GO:0000096,GO:0000097,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006082,GO:0006518,GO:0006520,GO:0006547,GO:0006548,GO:0006575,GO:0006577,GO:0006578,GO:0006725,GO:0006749,GO:0006751,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009056,GO:0009058,GO:0009063,GO:0009987,GO:0016020,GO:0016053,GO:0016054,GO:0019439,GO:0019752,GO:0032991,GO:0034641,GO:0042219,GO:0042398,GO:0043171,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044272,GO:0044273,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046395,GO:0046483,GO:0046700,GO:0051186,GO:0051187,GO:0052698,GO:0052699,GO:0052701,GO:0052703,GO:0052704,GO:0052708,GO:0052803,GO:0052805,GO:0061672,GO:0071704,GO:0071944,GO:0097164,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1902494,GO:1905368 3.5.1.118 ko:K07008 ko00340,map00340 - R11021 RC00064,RC00090 ko00000,ko00001,ko01000 - - - GATase_6 k59_1365569_1 1267534.KB906754_gene3787 0.000275 43.1 COG0577@1|root,COG0577@2|Bacteria 2|Bacteria V efflux transmembrane transporter activity - - - - - - - - - - - - FtsX,MacB_PCD k59_1365569_2 649349.Lbys_2090 1.23e-25 107.0 COG2234@1|root,COG2234@2|Bacteria,4NE66@976|Bacteroidetes,47M14@768503|Cytophagia 976|Bacteroidetes G Peptidase, M28 PGCP - - - - - - - - - - - Peptidase_M28 k59_1534951_1 265072.Mfla_0720 6.19e-82 267.0 COG3383@1|root,COG3383@2|Bacteria,1QTZB@1224|Proteobacteria,2VP2Q@28216|Betaproteobacteria,2KKYD@206350|Nitrosomonadales 206350|Nitrosomonadales C TIGRFAM formate dehydrogenase, alpha subunit - - 1.17.1.9 ko:K00123 ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200 - R00519 RC02796 ko00000,ko00001,ko01000 - - - Fer2_4,Fer4,Fer4_6,Fer4_7,Fer4_9,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3 k59_1760758_1 1054213.HMPREF9946_02554 5.49e-98 315.0 COG1305@1|root,COG4196@1|root,COG1305@2|Bacteria,COG4196@2|Bacteria,1MVAG@1224|Proteobacteria,2TSVH@28211|Alphaproteobacteria,2JPVV@204441|Rhodospirillales 204441|Rhodospirillales E Transglutaminase/protease-like homologues - - - - - - - - - - - - Bact_transglu_N,DUF2126,Transglut_core k59_1760758_2 886293.Sinac_1351 2.29e-62 210.0 COG0058@1|root,COG0058@2|Bacteria,2IY0J@203682|Planctomycetes 203682|Planctomycetes G COG0058 Glucan phosphorylase - - 2.4.1.1 ko:K00688 ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931 - R02111 - ko00000,ko00001,ko01000 - GT35 - DUF3417,Phosphorylase k59_292478_1 1123261.AXDW01000006_gene2464 1.35e-133 385.0 COG0462@1|root,COG0462@2|Bacteria,1MW21@1224|Proteobacteria,1RMUC@1236|Gammaproteobacteria,1X3Z0@135614|Xanthomonadales 135614|Xanthomonadales F Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) prs - 2.7.6.1 ko:K00948 ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230 M00005 R01049 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - Pribosyl_synth,Pribosyltran_N k59_913416_1 194867.ALBQ01000013_gene740 2.99e-49 167.0 COG0789@1|root,COG1192@1|root,COG0789@2|Bacteria,COG1192@2|Bacteria,1MVJU@1224|Proteobacteria,2TRYQ@28211|Alphaproteobacteria,2K10I@204457|Sphingomonadales 204457|Sphingomonadales D Chromosome partitioning - - - ko:K03496 - - - - ko00000,ko03036,ko04812 - - - AAA_31 k59_1590936_1 1137281.D778_00249 2.11e-96 293.0 COG0147@1|root,COG0147@2|Bacteria,4NFQ5@976|Bacteroidetes,1HXSE@117743|Flavobacteriia 976|Bacteroidetes EH Anthranilate synthase trpE - 4.1.3.27 ko:K01657 ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025 M00023 R00985,R00986 RC00010,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 - - - Anth_synt_I_N,Chorismate_bind k59_1027157_1 1122137.AQXF01000004_gene1630 5.49e-86 280.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2TQT0@28211|Alphaproteobacteria 28211|Alphaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_1027157_2 1122137.AQXF01000004_gene1631 4.2e-57 192.0 COG0845@1|root,COG0845@2|Bacteria,1PEVY@1224|Proteobacteria 1224|Proteobacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - - - - - - - - - - Biotin_lipoyl_2,HlyD_3 k59_630805_2 1122137.AQXF01000001_gene2803 9.6e-269 736.0 COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,2TR15@28211|Alphaproteobacteria 28211|Alphaproteobacteria I acyl-CoA dehydrogenase - - 1.3.8.8 ko:K00255 ko00071,ko01100,ko01212,ko03320,map00071,map01100,map01212,map03320 M00087 R01279,R03777,R03857,R03990,R04751,R04754 RC00052 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_905218_1 358220.C380_02745 8.79e-07 53.5 COG3794@1|root,COG3794@2|Bacteria,1RHQU@1224|Proteobacteria,2VSJJ@28216|Betaproteobacteria,4AEGW@80864|Comamonadaceae 28216|Betaproteobacteria C PFAM blue (type 1) copper domain protein - - - - - - - - - - - - - k59_1131387_1 1188252.AJYK01000068_gene228 1.81e-62 214.0 COG2352@1|root,COG2352@2|Bacteria,1MUD5@1224|Proteobacteria,1RPTP@1236|Gammaproteobacteria,1XUG5@135623|Vibrionales 135623|Vibrionales H Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle ppc GO:0003674,GO:0003824,GO:0004611,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0008964,GO:0009060,GO:0009987,GO:0015980,GO:0016829,GO:0016830,GO:0016831,GO:0016999,GO:0017144,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0055114,GO:0071704,GO:0072350 4.1.1.31 ko:K01595 ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200 M00168,M00170,M00171,M00172,M00173,M00346,M00374 R00345 RC02741 ko00000,ko00001,ko00002,ko01000 - - - PEPcase k59_58130_1 556269.ACDQ01000013_gene592 7.79e-52 174.0 COG0667@1|root,COG0667@2|Bacteria,1MV2Y@1224|Proteobacteria,2VHH9@28216|Betaproteobacteria,474CW@75682|Oxalobacteraceae 28216|Betaproteobacteria C Aldo/keto reductase family - - - - - - - - - - - - Aldo_ket_red k59_961805_2 1282876.BAOK01000001_gene2937 1.08e-25 105.0 COG3239@1|root,COG3239@2|Bacteria,1MUHK@1224|Proteobacteria,2TSTR@28211|Alphaproteobacteria 28211|Alphaproteobacteria I Fatty acid desaturase MA20_28095 - - - - - - - - - - - FA_desaturase k59_1752702_1 1348657.M622_04365 8.79e-10 65.1 COG0815@1|root,COG0815@2|Bacteria,1MUBU@1224|Proteobacteria,2VH1I@28216|Betaproteobacteria,2KUSA@206389|Rhodocyclales 206389|Rhodocyclales M Transfers the fatty acyl group on membrane lipoproteins lnt - - ko:K03820 - - - - ko00000,ko01000 - GT2 - CN_hydrolase k59_1244448_1 391615.ABSJ01000042_gene2279 1.05e-66 224.0 COG4796@1|root,COG4796@2|Bacteria,1QTT6@1224|Proteobacteria,1RN3Z@1236|Gammaproteobacteria,1J8IZ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria U Secretin and TonB N terminus short domain pilQ GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0006139,GO:0006259,GO:0006308,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0015976,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901361,GO:1901363,GO:1901575 - ko:K02507,ko:K02666 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - AMIN,STN,Secretin,Secretin_N k59_1426_1 1144305.PMI02_03418 2.7e-37 126.0 2ECT0@1|root,32RXS@2|Bacteria,1N6EY@1224|Proteobacteria,2UJ21@28211|Alphaproteobacteria,2K7E4@204457|Sphingomonadales 204457|Sphingomonadales - - - - - - - - - - - - - - - k59_1426_2 875328.JDM601_3367 2.29e-16 77.8 COG1804@1|root,COG1804@2|Bacteria,2GRB0@201174|Actinobacteria,2354S@1762|Mycobacteriaceae 201174|Actinobacteria C L-carnitine dehydratase bile acid-inducible protein F - - - - - - - - - - - - CoA_transf_3 k59_848916_2 247633.GP2143_06883 8.5e-47 158.0 COG0189@1|root,COG0189@2|Bacteria,1MX62@1224|Proteobacteria,1RM8B@1236|Gammaproteobacteria,1J55C@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria F COG0189 Glutathione synthase Ribosomal protein S6 modification enzyme (glutaminyl transferase) rimK GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0016874,GO:0016879,GO:0016881,GO:0018169,GO:0018410,GO:0019538,GO:0031668,GO:0033554,GO:0036211,GO:0042802,GO:0043170,GO:0043412,GO:0043687,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0050896,GO:0051716,GO:0070739,GO:0071496,GO:0071704,GO:0140096,GO:1901564 - ko:K05844 - - - - ko00000,ko01000,ko03009 - - - RimK k59_1074673_1 1122137.AQXF01000001_gene2748 3.76e-69 227.0 COG1505@1|root,COG1505@2|Bacteria,1NZ7N@1224|Proteobacteria,2TTAX@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Prolyl oligopeptidase ppcE - 3.4.21.26 ko:K01322 ko04614,map04614 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_S9,Peptidase_S9_N k59_1074673_2 1333998.M2A_0928 9.02e-72 223.0 COG0491@1|root,COG0491@2|Bacteria,1MU8Q@1224|Proteobacteria,2TSVS@28211|Alphaproteobacteria,4BPZF@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria S Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid gloB - 3.1.2.6 ko:K01069 ko00620,map00620 - R01736 RC00004,RC00137 ko00000,ko00001,ko01000 - - - HAGH_C,Lactamase_B k59_171127_1 314287.GB2207_02800 4.36e-80 262.0 COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,1RPCB@1236|Gammaproteobacteria,1J4ZW@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner lon GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0004175,GO:0004176,GO:0004252,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006515,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0009056,GO:0009057,GO:0009266,GO:0009314,GO:0009408,GO:0009628,GO:0009987,GO:0010165,GO:0010212,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0017171,GO:0019538,GO:0030163,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051603,GO:0070011,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575 3.4.21.53 ko:K01338 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - AAA,LON_substr_bdg,Lon_C k59_1074682_1 1392490.JHZX01000001_gene367 1.89e-120 358.0 COG0681@1|root,COG0681@2|Bacteria,4NFTP@976|Bacteroidetes,1HY4X@117743|Flavobacteriia 976|Bacteroidetes U Belongs to the peptidase S26 family lepB - 3.4.21.89 ko:K03100 ko02024,ko03060,map02024,map03060 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_S24,Peptidase_S26 k59_114580_1 502025.Hoch_2274 1.58e-52 183.0 COG1297@1|root,COG1297@2|Bacteria,1N7SK@1224|Proteobacteria,42PMM@68525|delta/epsilon subdivisions,2WWD4@28221|Deltaproteobacteria,2YTYG@29|Myxococcales 28221|Deltaproteobacteria S oligopeptide transporter, OPT family - - - - - - - - - - - - OPT k59_622910_1 1197477.IA57_08925 1.41e-236 673.0 COG0209@1|root,COG0209@2|Bacteria,4NEHQ@976|Bacteroidetes,1HXGF@117743|Flavobacteriia 976|Bacteroidetes F Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen nrd - 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - Ribonuc_red_lgC,Ribonuc_red_lgN k59_1018686_1 1046627.BZARG_2531 1.12e-82 265.0 2C5U1@1|root,2Z80K@2|Bacteria,4NG4G@976|Bacteroidetes,1HZNR@117743|Flavobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - DUF748 k59_1074688_1 436308.Nmar_0926 2.4e-98 304.0 COG0441@1|root,arCOG00401@2157|Archaea,41S9K@651137|Thaumarchaeota 651137|Thaumarchaeota J Belongs to the class-II aminoacyl-tRNA synthetase family thrS - 6.1.1.3 ko:K01868 ko00970,map00970 M00359,M00360 R03663 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,tRNA-Thr_ED,tRNA-synt_2b k59_509928_1 926562.Oweho_2792 5.27e-46 170.0 COG1409@1|root,COG1409@2|Bacteria,4NEQ8@976|Bacteroidetes,1I0MD@117743|Flavobacteriia 976|Bacteroidetes S Ser Thr phosphatase family protein - - - - - - - - - - - - Metallophos k59_1074692_1 247490.KSU1_C0797 2.89e-13 74.7 COG3642@1|root,COG3642@2|Bacteria 247490.KSU1_C0797|- T kinase activity - - - - - - - - - - - - - k59_1074692_2 96561.Dole_1431 1.6e-27 119.0 COG0795@1|root,COG0795@2|Bacteria,1MUF2@1224|Proteobacteria,42NYD@68525|delta/epsilon subdivisions,2WKHT@28221|Deltaproteobacteria,2MHU9@213118|Desulfobacterales 28221|Deltaproteobacteria S permease YjgP YjgQ family lptF - - ko:K07091 ko02010,map02010 M00320 - - ko00000,ko00001,ko00002,ko02000 1.B.42.1 - - YjgP_YjgQ k59_58169_1 1458427.BAWN01000024_gene1456 1.74e-29 114.0 COG0247@1|root,COG0247@2|Bacteria,1MWTK@1224|Proteobacteria,2VISA@28216|Betaproteobacteria,4AAZ5@80864|Comamonadaceae 28216|Betaproteobacteria C 4Fe-4S ferredoxin iron-sulfur binding domain protein glcF - - ko:K11473 ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130 - R00475 RC00042 ko00000,ko00001 - - - CCG,Fer4_7,Fer4_8 k59_453355_1 985054.JQEZ01000008_gene507 1.43e-39 139.0 COG0625@1|root,COG0625@2|Bacteria,1N1H5@1224|Proteobacteria,2VFQ0@28211|Alphaproteobacteria 28211|Alphaproteobacteria O Glutathione S-transferase, N-terminal domain - - - - - - - - - - - - - k59_1470461_1 864051.BurJ1DRAFT_4688 2.18e-54 180.0 COG1999@1|root,COG1999@2|Bacteria,1REUE@1224|Proteobacteria,2WA2J@28216|Betaproteobacteria,1KNIJ@119065|unclassified Burkholderiales 28216|Betaproteobacteria S SCO1/SenC - - - ko:K07152 - - - - ko00000,ko03029 - - - SCO1-SenC k59_1131435_1 1286632.P278_24240 2.54e-41 146.0 COG0446@1|root,COG0446@2|Bacteria,4NFUW@976|Bacteroidetes,1HY2U@117743|Flavobacteriia 976|Bacteroidetes S Pyridine nucleotide-disulphide oxidoreductase - - - - - - - - - - - - Pyr_redox_2 k59_1131435_2 1094466.KQS_02150 1.33e-13 69.3 COG4192@1|root,COG4192@2|Bacteria,4NFY7@976|Bacteroidetes,1HX1N@117743|Flavobacteriia,2NSVZ@237|Flavobacterium 976|Bacteroidetes T Domain of unknown function (DUF4407) - - - - - - - - - - - - DUF4407 k59_1583296_1 1207063.P24_00445 6.36e-91 276.0 COG2833@1|root,COG2833@2|Bacteria,1MW0V@1224|Proteobacteria,2TQJU@28211|Alphaproteobacteria,2JPH7@204441|Rhodospirillales 204441|Rhodospirillales S protein conserved in bacteria - - - - - - - - - - - - DUF455 k59_1583296_2 588932.JHOF01000018_gene857 2.94e-23 92.4 COG1225@1|root,COG1225@2|Bacteria,1RD4R@1224|Proteobacteria,2U6Z9@28211|Alphaproteobacteria,2KGSV@204458|Caulobacterales 204458|Caulobacterales O PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen - - 1.11.1.15 ko:K03564 - - - - ko00000,ko01000 - - - AhpC-TSA k59_1131442_1 1502770.JQMG01000001_gene1773 8.65e-47 159.0 COG1162@1|root,COG1162@2|Bacteria,1MUEF@1224|Proteobacteria,2VINY@28216|Betaproteobacteria,2KM0D@206350|Nitrosomonadales 206350|Nitrosomonadales S One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit rsgA - 3.1.3.100 ko:K06949 ko00730,ko01100,map00730,map01100 - R00615,R02135 RC00002,RC00017 ko00000,ko00001,ko01000,ko03009 - - - RsgA_GTPase k59_792661_1 1088721.NSU_4912 7.81e-07 50.8 COG3524@1|root,COG3524@2|Bacteria,1R3ZY@1224|Proteobacteria,2U0I2@28211|Alphaproteobacteria,2K2BB@204457|Sphingomonadales 204457|Sphingomonadales M COG3524 Capsule polysaccharide export protein - - - ko:K10107 ko02010,map02010 M00249 - - ko00000,ko00001,ko00002,ko02000 3.A.1.101 - - Wzz k59_1074719_1 1056512.D515_02504 1.64e-66 215.0 COG1228@1|root,COG1228@2|Bacteria,1MUYR@1224|Proteobacteria,1RMI9@1236|Gammaproteobacteria,1XSFM@135623|Vibrionales 135623|Vibrionales F COG1228 Imidazolonepropionase and related amidohydrolases hutI GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006547,GO:0006548,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009987,GO:0016054,GO:0016787,GO:0016810,GO:0016812,GO:0019439,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0046395,GO:0046483,GO:0046700,GO:0052803,GO:0052805,GO:0071704,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 3.5.2.7 ko:K01468 ko00340,ko01100,map00340,map01100 M00045 R02288 RC00683 ko00000,ko00001,ko00002,ko01000 - - - Amidohydro_1,Amidohydro_3 k59_679441_1 715226.ABI_44930 4.19e-63 204.0 COG1609@1|root,COG1609@2|Bacteria,1MUEP@1224|Proteobacteria,2U7WF@28211|Alphaproteobacteria 28211|Alphaproteobacteria K Periplasmic binding protein-like domain - - - ko:K06145 - - - - ko00000,ko03000 - - - LacI,Peripla_BP_3 k59_566659_1 216142.LT40_16230 3.08e-51 166.0 COG0242@1|root,COG0242@2|Bacteria,1RA2P@1224|Proteobacteria,1S247@1236|Gammaproteobacteria 1236|Gammaproteobacteria J Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions def - 3.5.1.88 ko:K01462 - - - - ko00000,ko01000 - - - Pep_deformylase k59_1639827_1 555779.Dthio_PD3188 2.62e-65 218.0 COG5433@1|root,COG5433@2|Bacteria,1MXB5@1224|Proteobacteria,431TI@68525|delta/epsilon subdivisions,2WWAP@28221|Deltaproteobacteria,2MB98@213115|Desulfovibrionales 28221|Deltaproteobacteria L DDE_Tnp_1-associated - - - - - - - - - - - - DDE_Tnp_1,DDE_Tnp_1_assoc,DUF4338 k59_1639827_2 314278.NB231_15263 7.56e-54 179.0 COG5433@1|root,COG5433@2|Bacteria 2|Bacteria L transposase activity - - - - - - - - - - - - DDE_Tnp_1,DDE_Tnp_1_assoc,DUF4338 k59_1187904_1 1545915.JROG01000004_gene2568 2.73e-52 176.0 COG0500@1|root,COG2226@2|Bacteria,1PTZF@1224|Proteobacteria,2V5SF@28211|Alphaproteobacteria,2K9JK@204457|Sphingomonadales 204457|Sphingomonadales Q ubiE/COQ5 methyltransferase family - - - - - - - - - - - - Methyltransf_25 k59_284289_1 999141.GME_09219 3.85e-08 59.7 COG0625@1|root,COG0625@2|Bacteria,1RA4Y@1224|Proteobacteria,1S2I8@1236|Gammaproteobacteria,1XJ5Z@135619|Oceanospirillales 135619|Oceanospirillales O Maleylacetoacetate isomerase - - 5.2.1.4 ko:K01801 ko00350,ko01100,ko01120,map00350,map01100,map01120 - R03868 RC00867 ko00000,ko00001,ko01000 - - - GST_C_2,GST_C_3,GST_N,GST_N_3 k59_284289_2 1292034.OR37_02460 9e-17 79.0 COG2130@1|root,COG2130@2|Bacteria,1MUC2@1224|Proteobacteria,2TQYM@28211|Alphaproteobacteria,2KFCR@204458|Caulobacterales 204458|Caulobacterales S N-terminal domain of oxidoreductase - - - ko:K07119 - - - - ko00000 - - - ADH_N_2,ADH_zinc_N k59_397070_1 111781.Lepto7376_2640 3.63e-57 202.0 COG0004@1|root,COG0642@1|root,COG0784@1|root,COG0004@2|Bacteria,COG0784@2|Bacteria,COG2205@2|Bacteria,1G09B@1117|Cyanobacteria,1HHZA@1150|Oscillatoriales 1117|Cyanobacteria T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - 2.1.1.80,3.1.1.61 ko:K03320,ko:K13924 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko02000,ko02022,ko02035 1.A.11 - - GAF,HAMP,HATPase_c,HisKA,MASE1,PAS_3,PAS_4,PAS_9,Response_reg,dCache_1 k59_340637_1 436308.Nmar_1532 1.76e-13 65.1 arCOG10590@1|root,arCOG10590@2157|Archaea,41SSG@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_340637_2 1229909.NSED_08420 3.26e-85 256.0 COG0533@1|root,arCOG01185@2157|Archaea,41SJJ@651137|Thaumarchaeota 651137|Thaumarchaeota T Mn2 -dependent serine threonine protein kinase - - 2.7.11.1 ko:K08851 - - - - ko00000,ko01000,ko01001,ko03016 - - - Pkinase k59_1413890_1 1121937.AUHJ01000007_gene1895 4.18e-10 59.3 COG2197@1|root,COG2197@2|Bacteria,1RDI0@1224|Proteobacteria,1RS5N@1236|Gammaproteobacteria,467VP@72275|Alteromonadaceae 1236|Gammaproteobacteria K COG2771 DNA-binding HTH domain-containing proteins - - - - - - - - - - - - GerE k59_1413890_2 1121937.AUHJ01000007_gene1894 2.53e-59 194.0 COG0174@1|root,COG0174@2|Bacteria,1MU6V@1224|Proteobacteria,1RPNZ@1236|Gammaproteobacteria,465I0@72275|Alteromonadaceae 1236|Gammaproteobacteria E Glutamine synthetase, catalytic domain - - 6.3.1.2 ko:K01915 ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 - R00253 RC00010,RC02798 ko00000,ko00001,ko01000,ko04147 - - - Gln-synt_C k59_679475_1 555793.WSK_1208 1.98e-85 261.0 COG2866@1|root,COG2866@2|Bacteria,1MUMN@1224|Proteobacteria,2TREN@28211|Alphaproteobacteria,2K01Q@204457|Sphingomonadales 204457|Sphingomonadales E Carboxypeptidase - - - - - - - - - - - - Peptidase_M14 k59_679475_2 1144305.PMI02_02303 8.82e-05 42.7 COG0295@1|root,COG0295@2|Bacteria,1RKQ5@1224|Proteobacteria,2U96B@28211|Alphaproteobacteria,2KD8D@204457|Sphingomonadales 204457|Sphingomonadales F This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis cdd - 3.5.4.5 ko:K01489 ko00240,ko00983,ko01100,map00240,map00983,map01100 - R01878,R02485,R08221 RC00074,RC00514 ko00000,ko00001,ko01000 - - - dCMP_cyt_deam_1,dCMP_cyt_deam_2 k59_736132_1 339671.Asuc_1057 3.52e-13 68.9 COG0809@1|root,COG0809@2|Bacteria,1MUH3@1224|Proteobacteria,1RMKW@1236|Gammaproteobacteria,1Y7EQ@135625|Pasteurellales 135625|Pasteurellales F Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) queA GO:0002097,GO:0002099,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016853,GO:0018130,GO:0019438,GO:0034404,GO:0034470,GO:0034641,GO:0034654,GO:0034660,GO:0042455,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0051075,GO:0055086,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.4.99.17 ko:K07568 - - - - ko00000,ko01000,ko03016 - - - Queuosine_synth k59_736132_2 1122201.AUAZ01000012_gene1364 2.9e-108 322.0 COG0343@1|root,COG0343@2|Bacteria,1MUCA@1224|Proteobacteria,1RMY3@1236|Gammaproteobacteria,464DG@72275|Alteromonadaceae 1236|Gammaproteobacteria J Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) tgt GO:0002097,GO:0002099,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008270,GO:0008479,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0034404,GO:0034470,GO:0034641,GO:0034654,GO:0034660,GO:0042455,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046116,GO:0046483,GO:0046872,GO:0046914,GO:0055086,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.4.2.29 ko:K00773 - - R03789,R10209 RC00063 ko00000,ko01000,ko03016 - - iECW_1372.ECW_m0475,iWFL_1372.ECW_m0475 TGT k59_792701_1 1122137.AQXF01000004_gene1630 2.68e-66 226.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2TQT0@28211|Alphaproteobacteria 28211|Alphaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_622971_1 391613.RTM1035_19521 2.65e-39 144.0 COG0142@1|root,COG0142@2|Bacteria,1MUK6@1224|Proteobacteria,2TSDZ@28211|Alphaproteobacteria,46PIA@74030|Roseovarius 28211|Alphaproteobacteria H Belongs to the FPP GGPP synthase family ispB GO:0003674,GO:0003824,GO:0004659,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006066,GO:0006629,GO:0006720,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009108,GO:0009987,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0042180,GO:0042181,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901615,GO:1901617,GO:1901661,GO:1901663 2.5.1.90 ko:K02523 ko00900,ko01110,map00900,map01110 - R09248 RC00279 ko00000,ko00001,ko01000,ko01006 - - - polyprenyl_synt k59_622971_2 1415780.JPOG01000001_gene192 6.5e-52 181.0 COG0156@1|root,COG0156@2|Bacteria,1MVVH@1224|Proteobacteria,1RNS6@1236|Gammaproteobacteria,1X31B@135614|Xanthomonadales 135614|Xanthomonadales H Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide bioF - 2.3.1.47 ko:K00652 ko00780,ko01100,map00780,map01100 M00123,M00573,M00577 R03210,R10124 RC00004,RC00039,RC02725 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 k59_1639871_1 1122169.AREN01000004_gene421 6.48e-09 55.1 COG1872@1|root,COG1872@2|Bacteria,1MZ4E@1224|Proteobacteria,1S9AB@1236|Gammaproteobacteria,1JEZQ@118969|Legionellales 118969|Legionellales S Belongs to the UPF0235 family - - - ko:K09131 - - - - ko00000 - - - DUF167 k59_1639871_2 1283284.AZUK01000001_gene976 3.51e-10 60.8 COG2331@1|root,COG2331@2|Bacteria,1N6Q9@1224|Proteobacteria,1SCJS@1236|Gammaproteobacteria,1Y4X4@135624|Aeromonadales 135624|Aeromonadales S Putative regulatory protein - - - - - - - - - - - - Zn-ribbon_8 k59_1639871_3 397288.C806_02250 3.06e-07 52.0 COG0190@1|root,COG0190@2|Bacteria,1TP1P@1239|Firmicutes,248DB@186801|Clostridia,27IT1@186928|unclassified Lachnospiraceae 186801|Clostridia H Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate folD - 1.5.1.5,3.5.4.9 ko:K01491 ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200 M00140,M00377 R01220,R01655 RC00202,RC00578 ko00000,ko00001,ko00002,ko01000 - - - THF_DHG_CYH,THF_DHG_CYH_C k59_510020_1 519989.ECTPHS_04955 8.99e-51 176.0 COG1030@1|root,COG1030@2|Bacteria,1MUJN@1224|Proteobacteria,1RN3U@1236|Gammaproteobacteria,1WXRD@135613|Chromatiales 135613|Chromatiales O NfeD-like C-terminal, partner-binding - - - ko:K07403 - - - - ko00000 - - - NfeD k59_510027_1 1411685.U062_01723 2.6e-70 232.0 COG4206@1|root,COG4206@2|Bacteria,1MW63@1224|Proteobacteria,1RMFJ@1236|Gammaproteobacteria,1J6E9@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P TonB dependent receptor btuB - - ko:K16092 - - - - ko00000,ko02000 1.B.14.3 - - Plug,TonB_dep_Rec k59_792725_1 2340.JV46_12140 1.2e-16 78.6 COG3159@1|root,COG3159@2|Bacteria,1R4BP@1224|Proteobacteria,1S9SC@1236|Gammaproteobacteria,1J612@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S protein conserved in bacteria yigA - - ko:K09921 - - - - ko00000 - - - DUF484 k59_792725_2 1301098.PKB_5621 1.44e-56 189.0 COG4973@1|root,COG4973@2|Bacteria,1MUJJ@1224|Proteobacteria,1RMJG@1236|Gammaproteobacteria 1236|Gammaproteobacteria D Belongs to the 'phage' integrase family. XerC subfamily xerC GO:0000150,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006276,GO:0006310,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008907,GO:0009009,GO:0009037,GO:0009987,GO:0015074,GO:0032991,GO:0034641,GO:0042150,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0048476,GO:0071139,GO:0071704,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363 - ko:K03733 - - - - ko00000,ko03036 - - - Phage_int_SAM_1,Phage_integrase k59_1131500_1 553385.JEMF01000039_gene2928 3.04e-53 182.0 COG0306@1|root,COG0306@2|Bacteria,1MVXK@1224|Proteobacteria,1RP0Q@1236|Gammaproteobacteria,1XIG9@135619|Oceanospirillales 135619|Oceanospirillales P phosphate transporter - - - ko:K03306 - - - - ko00000 2.A.20 - - PHO4 k59_171296_1 1499685.CCFJ01000046_gene3398 5.37e-49 174.0 COG0443@1|root,COG0443@2|Bacteria,1TP1J@1239|Firmicutes,4HA9S@91061|Bacilli,1ZAZ2@1386|Bacillus 91061|Bacilli O Heat shock 70 kDa protein dnaK GO:0001871,GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0008150,GO:0009986,GO:0030246,GO:0030247,GO:0044464,GO:0051704,GO:0098630,GO:0098743,GO:2001065 - ko:K04043 ko03018,ko04212,ko05152,map03018,map04212,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 1.A.33.1 - - HSP70 k59_227545_1 1242864.D187_007876 2.13e-11 68.9 COG0577@1|root,COG0577@2|Bacteria,1MWBK@1224|Proteobacteria,42PZC@68525|delta/epsilon subdivisions,2WK59@28221|Deltaproteobacteria 28221|Deltaproteobacteria V ABC-type transport system involved in lipoprotein release permease component - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_1470563_1 1229909.NSED_00720 8.55e-81 249.0 COG0079@1|root,arCOG04273@2157|Archaea,41SGB@651137|Thaumarchaeota 651137|Thaumarchaeota E PFAM Aminotransferase class I and II - - 2.6.1.9 ko:K00817 ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230 M00026 R00694,R00734,R03243 RC00006,RC00888 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 k59_792731_1 436308.Nmar_1616 2.59e-106 310.0 COG0108@1|root,arCOG01320@2157|Archaea,41SFW@651137|Thaumarchaeota 651137|Thaumarchaeota H Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate - - 4.1.99.12 ko:K02858 ko00740,ko01100,ko01110,map00740,map01100,map01110 M00125 R07281 RC01792,RC01815 ko00000,ko00001,ko00002,ko01000 - - - DHBP_synthase k59_792731_2 1122947.FR7_3283 2.98e-15 73.9 COG0307@1|root,COG0307@2|Bacteria,1V1EP@1239|Firmicutes,4H4M4@909932|Negativicutes 909932|Negativicutes H riboflavin synthase, alpha ribE - 2.5.1.9 ko:K00793 ko00740,ko01100,ko01110,map00740,map01100,map01110 M00125 R00066 RC00958,RC00960 ko00000,ko00001,ko00002,ko01000 - - - Lum_binding k59_58272_2 378806.STAUR_4024 2.72e-38 132.0 COG0662@1|root,COG0662@2|Bacteria,1NADF@1224|Proteobacteria,4383M@68525|delta/epsilon subdivisions,2X9WE@28221|Deltaproteobacteria,2YVKF@29|Myxococcales 28221|Deltaproteobacteria G Mannose-6-phosphate isomerase - - - - - - - - - - - - Cupin_2 k59_58272_3 264731.PRU_1542 1.02e-05 54.7 COG0451@1|root,COG0451@2|Bacteria,4NEKA@976|Bacteroidetes,2FMUU@200643|Bacteroidia 976|Bacteroidetes M NAD dependent epimerase dehydratase family - - - - - - - - - - - - Epimerase,GDP_Man_Dehyd k59_736183_1 68219.JNXI01000003_gene4897 1.44e-34 140.0 COG3291@1|root,COG3291@2|Bacteria,2GJR2@201174|Actinobacteria 201174|Actinobacteria S Pkd domain containing protein - - - - - - - - - - - - CBM_4_9 k59_171322_1 1001585.MDS_3772 4.57e-128 385.0 COG0443@1|root,COG0443@2|Bacteria,1MVQI@1224|Proteobacteria,1RN74@1236|Gammaproteobacteria,1YCW7@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria O Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB hscA GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0009266,GO:0009409,GO:0009628,GO:0009987,GO:0010467,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033554,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043531,GO:0044238,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0050896,GO:0051604,GO:0051716,GO:0070417,GO:0071704,GO:0097159,GO:0097367,GO:0097428,GO:1901265,GO:1901363,GO:1901564,GO:1902494,GO:1990230,GO:1990234 - ko:K04044 - - - - ko00000,ko03110 1.A.33 - - HSP70 k59_566788_1 526222.Desal_1789 5.36e-46 168.0 COG0845@1|root,COG0845@2|Bacteria,1MVAS@1224|Proteobacteria,42PKU@68525|delta/epsilon subdivisions,2WM5K@28221|Deltaproteobacteria,2M9X5@213115|Desulfovibrionales 28221|Deltaproteobacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - ko:K07798,ko:K15727 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.6.1.4,8.A.1,8.A.1.2.1 - - DUF3347,HlyD_D23 k59_1018843_1 1353276.JADR01000001_gene279 9.29e-80 250.0 COG0124@1|root,COG0124@2|Bacteria,4NE8N@976|Bacteroidetes,1HX0E@117743|Flavobacteriia 976|Bacteroidetes J histidyl-tRNA synthetase hisS - 6.1.1.21 ko:K01892 ko00970,map00970 M00359,M00360 R03655 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,tRNA-synt_His k59_1357549_1 323098.Nwi_1198 0.00022 47.0 COG0642@1|root,COG0642@2|Bacteria,1QTVA@1224|Proteobacteria,2U5EI@28211|Alphaproteobacteria,3JRC5@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria T HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain MA20_15235 - - - - - - - - - - - HAMP,HATPase_c,HisKA k59_1357549_2 1247963.JPHU01000008_gene2780 1.54e-25 99.4 COG0745@1|root,COG0745@2|Bacteria,1MU67@1224|Proteobacteria,2TRTZ@28211|Alphaproteobacteria 28211|Alphaproteobacteria T COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain ragA GO:0000160,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005515,GO:0006355,GO:0007154,GO:0007165,GO:0008150,GO:0009889,GO:0009893,GO:0009987,GO:0010035,GO:0010038,GO:0010468,GO:0010556,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0023052,GO:0031323,GO:0031326,GO:0035556,GO:0042221,GO:0042802,GO:0046688,GO:0048518,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0051716,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2000112,GO:2001141 - ko:K02483 - - - - ko00000,ko02022 - - - Response_reg,Trans_reg_C k59_1018854_1 1088721.NSU_1693 6.39e-49 158.0 COG1981@1|root,COG1981@2|Bacteria,1RHGS@1224|Proteobacteria,2U987@28211|Alphaproteobacteria,2K4J9@204457|Sphingomonadales 204457|Sphingomonadales S membrane - - - ko:K08973 - - - - ko00000 - - - UPF0093 k59_1018854_2 158500.BV97_02106 1.35e-60 195.0 COG0407@1|root,COG0407@2|Bacteria,1MUG1@1224|Proteobacteria,2TQQV@28211|Alphaproteobacteria,2JZZP@204457|Sphingomonadales 204457|Sphingomonadales H Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III hemE - 4.1.1.37 ko:K01599 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R03197,R04972 RC00872 ko00000,ko00001,ko00002,ko01000 - - - URO-D k59_1189251_1 331869.BAL199_11431 1.15e-63 205.0 COG0180@1|root,COG0180@2|Bacteria,1MV4T@1224|Proteobacteria,2TQZX@28211|Alphaproteobacteria,4BPHJ@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria J PFAM tRNA synthetases class I (W and Y) trpS - 6.1.1.2 ko:K01867 ko00970,map00970 M00359,M00360 R03664 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_1b k59_116284_1 322710.Avin_44060 1.2e-66 227.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria 1236|Gammaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K03296,ko:K18138 ko01501,ko01503,map01501,map01503 M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000 2.A.6.2 - - ACR_tran k59_680753_1 1123279.ATUS01000001_gene1776 7.14e-110 329.0 COG0446@1|root,COG0446@2|Bacteria,1NR3M@1224|Proteobacteria,1RN6P@1236|Gammaproteobacteria,1J52G@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P Reductase C-terminal alkT - 1.18.1.3 ko:K00529 ko00071,ko00360,ko01120,ko01220,map00071,map00360,map01120,map01220 M00545 R02000,R06782,R06783 RC00098 br01602,ko00000,ko00001,ko00002,ko01000 - - - Pyr_redox_2,Reductase_C k59_580271_1 436308.Nmar_1647 2.5e-69 225.0 arCOG08812@1|root,arCOG08812@2157|Archaea,41T0K@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_636733_1 997346.HMPREF9374_0260 7.78e-32 124.0 COG0209@1|root,COG0209@2|Bacteria,1TPFH@1239|Firmicutes,4HA07@91061|Bacilli,27CQZ@186824|Thermoactinomycetaceae 91061|Bacilli F Class II vitamin B12-dependent ribonucleotide reductase nrdA - 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - Ribonuc_red_lgC,Ribonuc_red_lgN k59_1088759_1 1144305.PMI02_00838 3.36e-129 375.0 COG0500@1|root,COG2226@2|Bacteria,1N6KT@1224|Proteobacteria 1224|Proteobacteria Q Pfam Methyltransferase - - 2.1.1.163,2.1.1.201 ko:K03183 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116,M00117 R04990,R04993,R06859,R08774,R09736 RC00003,RC01253,RC01662 ko00000,ko00001,ko00002,ko01000 - - - Methyltransf_11,Methyltransf_25 k59_806791_2 1313421.JHBV01000032_gene1630 9.01e-31 120.0 COG2885@1|root,COG2885@2|Bacteria 2|Bacteria M chlorophyll binding - - - - - - - - - - - - OmpA k59_580276_1 314254.OA2633_05636 1.52e-25 103.0 COG4948@1|root,COG4948@2|Bacteria,1MW76@1224|Proteobacteria,2TR16@28211|Alphaproteobacteria,43X6A@69657|Hyphomonadaceae 28211|Alphaproteobacteria M Belongs to the mandelate racemase muconate lactonizing enzyme family - GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016853,GO:0016854,GO:0034641,GO:0043167,GO:0043169,GO:0043603,GO:0044237,GO:0046872,GO:0071704,GO:1901564 5.1.1.20 ko:K19802 - - R10938 RC03309 ko00000,ko01000 - - - MR_MLE_C,MR_MLE_N k59_1258092_1 258533.BN977_05936 4.29e-19 87.8 COG0491@1|root,COG0491@2|Bacteria,2H8JM@201174|Actinobacteria,232EN@1762|Mycobacteriaceae 201174|Actinobacteria S beta-lactamase - - - - - - - - - - - - Lactamase_B k59_1485013_1 1469557.JSWF01000046_gene219 9.03e-83 263.0 2DBXW@1|root,2ZBRY@2|Bacteria,4NM6W@976|Bacteroidetes,1HYMB@117743|Flavobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - DUF5017 k59_1144897_1 556268.OFAG_00816 1.25e-94 288.0 2DF4I@1|root,2ZQGA@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_806794_1 1122137.AQXF01000002_gene343 4.84e-91 280.0 COG0739@1|root,COG0739@2|Bacteria,1MVTF@1224|Proteobacteria,2TQZE@28211|Alphaproteobacteria 28211|Alphaproteobacteria M COG0739 Membrane proteins related to metalloendopeptidases MA20_30780 - - - - - - - - - - - Peptidase_M23 k59_1088768_1 1122137.AQXF01000007_gene3522 4e-22 99.0 COG0834@1|root,COG0834@2|Bacteria,1NE7N@1224|Proteobacteria 1224|Proteobacteria ET Bacterial extracellular solute-binding proteins, family 3 - - - - - - - - - - - - SBP_bac_3 k59_1088768_2 1206720.BAFQ01000150_gene3951 6.66e-11 64.3 COG2365@1|root,COG2365@2|Bacteria,2GK28@201174|Actinobacteria,4FV70@85025|Nocardiaceae 201174|Actinobacteria T Tyrosine phosphatase family ptpB - 3.1.3.48 ko:K01104 - - - - ko00000,ko01000 - - - Y_phosphatase3 k59_580277_1 1094184.KWO_0119940 5.55e-53 180.0 COG3867@1|root,COG3867@2|Bacteria,1R33X@1224|Proteobacteria,1RYK6@1236|Gammaproteobacteria 1236|Gammaproteobacteria G Arabinogalactan endo-beta-1,4-galactanase ganB - 3.2.1.89 ko:K01224 - - - - ko00000,ko01000 - - - Glyco_hydro_53 k59_580277_2 1134474.O59_001167 1.11e-160 465.0 COG0446@1|root,COG0446@2|Bacteria,1Q0P8@1224|Proteobacteria,1T1NQ@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Tryptophan halogenase - - 1.14.19.9 ko:K14266 ko00404,ko01130,map00404,map01130 M00789,M00790 R09570 RC00949 ko00000,ko00001,ko00002,ko01000 - - - Trp_halogenase k59_298659_1 1411685.U062_01112 2.45e-111 338.0 COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,1RME8@1236|Gammaproteobacteria,1J4WR@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins ftsH GO:0000166,GO:0003674,GO:0003824,GO:0004175,GO:0004176,GO:0004222,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0008270,GO:0009056,GO:0009057,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030145,GO:0030163,GO:0030554,GO:0031224,GO:0031226,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043273,GO:0044238,GO:0044425,GO:0044459,GO:0044464,GO:0046872,GO:0046914,GO:0070011,GO:0071704,GO:0071944,GO:0097159,GO:0097367,GO:0098796,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575 - ko:K03798 - M00742 - - ko00000,ko00002,ko01000,ko01002,ko03110 - - - AAA,FtsH_ext,Peptidase_M41 k59_1541101_2 377629.TERTU_3361 7.54e-53 184.0 COG2730@1|root,COG2730@2|Bacteria,1QS6K@1224|Proteobacteria,1RR7S@1236|Gammaproteobacteria,2PN8T@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria G Cellulase (glycosyl hydrolase family 5) - - 3.2.1.4 ko:K01179 ko00500,ko01100,map00500,map01100 - R06200,R11307,R11308 - ko00000,ko00001,ko01000 - GH5,GH9 - Cellulase k59_1766764_2 1459636.NTE_01313 7.11e-37 140.0 arCOG08812@1|root,arCOG08812@2157|Archaea,41SXB@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_523191_1 1150864.MILUP08_46677 6.53e-10 58.5 COG3508@1|root,COG3508@2|Bacteria,2GKZV@201174|Actinobacteria,4DA7H@85008|Micromonosporales 201174|Actinobacteria Q homogentisate 12-dioxygenase hmgA - 1.13.11.5 ko:K00451 ko00350,ko00643,ko01100,ko01120,map00350,map00643,map01100,map01120 M00044 R02519 RC00737 ko00000,ko00001,ko00002,ko01000 - - - HgmA k59_523191_2 938709.AUSH02000017_gene991 4.24e-18 85.5 COG3185@1|root,COG3185@2|Bacteria,4NFI7@976|Bacteroidetes 976|Bacteroidetes E 4-hydroxyphenylpyruvate dioxygenase hppD - 1.13.11.27 ko:K00457 ko00130,ko00350,ko00360,ko01100,map00130,map00350,map00360,map01100 M00044 R01372,R02521 RC00505,RC00738 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Glyoxalase,Glyoxalase_5 k59_241269_2 1499967.BAYZ01000073_gene2017 1.15e-05 47.8 COG1470@1|root,COG2885@1|root,COG1470@2|Bacteria,COG2885@2|Bacteria,2NPWP@2323|unclassified Bacteria 2|Bacteria M OmpA family - - - ko:K03286 - - - - ko00000,ko02000 1.B.6 - - DUF4384,DUF4625,OmpA,PEGA k59_410776_1 760117.JN27_09910 5.93e-111 328.0 COG3173@1|root,COG3173@2|Bacteria,1MWAK@1224|Proteobacteria,2VJ31@28216|Betaproteobacteria,474PP@75682|Oxalobacteraceae 28216|Betaproteobacteria S Phosphotransferase enzyme family - - - - - - - - - - - - APH k59_1088793_1 436308.Nmar_0444 8.54e-117 353.0 COG1215@1|root,arCOG01389@2157|Archaea,41SDD@651137|Thaumarchaeota 651137|Thaumarchaeota M Glycosyl transferase family group 2 - - - - - - - - - - - - Glyco_tranf_2_3 k59_693291_1 158500.BV97_01438 3.45e-22 94.0 COG0604@1|root,COG0604@2|Bacteria,1MV3W@1224|Proteobacteria,2TRW7@28211|Alphaproteobacteria,2K3AQ@204457|Sphingomonadales 204457|Sphingomonadales C Zinc-binding dehydrogenase - - - ko:K19745 ko00640,ko01100,map00640,map01100 - R00919 RC00095 ko00000,ko00001,ko01000 - - - ADH_N,ADH_zinc_N k59_693291_2 13690.CP98_04267 2.76e-60 195.0 COG1414@1|root,COG1414@2|Bacteria,1RA2W@1224|Proteobacteria,2U0RW@28211|Alphaproteobacteria,2K3WV@204457|Sphingomonadales 204457|Sphingomonadales K Bacterial transcriptional regulator - - - - - - - - - - - - HTH_IclR,IclR k59_1597278_1 713586.KB900536_gene1194 1.97e-82 256.0 COG0162@1|root,COG0162@2|Bacteria,1MVUQ@1224|Proteobacteria,1RPKC@1236|Gammaproteobacteria,1WX6G@135613|Chromatiales 135613|Chromatiales J Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) tyrS - 6.1.1.1 ko:K01866 ko00970,map00970 M00359,M00360 R02918 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - S4,tRNA-synt_1b k59_975056_1 383381.EH30_11860 2.34e-37 141.0 COG2010@1|root,COG4993@1|root,COG2010@2|Bacteria,COG4993@2|Bacteria,1MUQX@1224|Proteobacteria,2TS2Q@28211|Alphaproteobacteria,2K18E@204457|Sphingomonadales 204457|Sphingomonadales CG Dehydrogenase - - 1.1.9.1 ko:K17760 - - - - ko00000,ko01000 - - - Cytochrome_CBB3,PQQ,PQQ_2 k59_1654328_1 555793.WSK_2466 2.45e-100 310.0 COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,2TQNY@28211|Alphaproteobacteria,2K15Q@204457|Sphingomonadales 204457|Sphingomonadales KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance - - 2.7.6.5,3.1.7.2 ko:K00951,ko:K01139 ko00230,map00230 - R00336,R00429 RC00002,RC00078 ko00000,ko00001,ko01000,ko03009 - - - ACT_4,HD_4,RelA_SpoT,TGS k59_128823_1 1235802.C823_03166 1.49e-15 77.8 COG0515@1|root,COG2815@1|root,COG0515@2|Bacteria,COG2815@2|Bacteria,1TP3F@1239|Firmicutes,24BJ8@186801|Clostridia,25W9R@186806|Eubacteriaceae 186801|Clostridia KLT Protein kinase domain - - - - - - - - - - - - FHA,PASTA,PDZ_2,Pkinase,YARHG k59_636765_2 1123073.KB899241_gene2690 9.71e-15 73.6 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RRXX@1236|Gammaproteobacteria,1X5SE@135614|Xanthomonadales 135614|Xanthomonadales T Sigma-54 interaction domain - - - - - - - - - - - - HTH_8,Response_reg,Sigma54_activat k59_749686_1 1500894.JQNN01000001_gene1850 6.87e-33 132.0 COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,2VJTV@28216|Betaproteobacteria,47284@75682|Oxalobacteraceae 28216|Betaproteobacteria MU Outer membrane efflux protein - - - - - - - - - - - - OEP k59_1485066_1 1297863.APJF01000022_gene4417 1.55e-58 202.0 COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,2TRRY@28211|Alphaproteobacteria,3JRVU@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria C Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain MA20_04660 - 1.2.5.3 ko:K03520 - - R11168 RC02800 ko00000,ko01000 - - - Ald_Xan_dh_C,Ald_Xan_dh_C2 k59_1315148_1 279238.Saro_0845 1.07e-20 92.8 COG2206@1|root,COG2206@2|Bacteria,1MW7F@1224|Proteobacteria,2U4W9@28211|Alphaproteobacteria,2K9S0@204457|Sphingomonadales 204457|Sphingomonadales T Domain of unknown function (DUF3391) - - - - - - - - - - - - DUF3391,HD_5 k59_1315148_2 1088721.NSU_2644 1.84e-66 218.0 COG0471@1|root,COG0471@2|Bacteria,1MU0K@1224|Proteobacteria,2TSFS@28211|Alphaproteobacteria,2K30T@204457|Sphingomonadales 204457|Sphingomonadales P Transporter - - - - - - - - - - - - CitMHS,TrkA_C k59_1485074_1 330214.NIDE3570 1.34e-30 124.0 COG2203@1|root,COG3437@1|root,COG4191@1|root,COG2203@2|Bacteria,COG3437@2|Bacteria,COG4191@2|Bacteria,3J10H@40117|Nitrospirae 40117|Nitrospirae T Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - - - - - - - - - - GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_9,Response_reg k59_1485075_1 1384057.CD33_06380 3.66e-50 171.0 COG0451@1|root,COG0451@2|Bacteria,1VP6I@1239|Firmicutes,4ISWU@91061|Bacilli,3IYUB@400634|Lysinibacillus 91061|Bacilli GM Male sterility protein yfnG - 4.2.1.45,4.2.1.46 ko:K01709,ko:K01710 ko00520,ko00521,ko00523,ko00525,ko01055,ko01130,map00520,map00521,map00523,map00525,map01055,map01130 M00793 R02426,R06513 RC00402 ko00000,ko00001,ko00002,ko01000 - - - Epimerase,GDP_Man_Dehyd k59_693326_1 1088721.NSU_3833 1.34e-69 215.0 COG5342@1|root,COG5342@2|Bacteria,1NVB8@1224|Proteobacteria,2UAQU@28211|Alphaproteobacteria,2K5Q9@204457|Sphingomonadales 204457|Sphingomonadales S invasion associated locus B - - - - - - - - - - - - - k59_523213_1 316407.4062459 1.3e-115 345.0 COG3593@1|root,COG3593@2|Bacteria,1N2CB@1224|Proteobacteria,1RQN2@1236|Gammaproteobacteria,3XMAS@561|Escherichia 1236|Gammaproteobacteria L DNA synthesis involved in DNA repair ybjD GO:0000731,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0018130,GO:0019438,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:1901360,GO:1901362,GO:1901576 - ko:K07459 - - - - ko00000 - - - DUF2813 k59_72871_1 1229909.NSED_04760 6.33e-23 95.1 COG1378@1|root,arCOG02037@2157|Archaea,41T5N@651137|Thaumarchaeota 651137|Thaumarchaeota K transcriptional - - - - - - - - - - - - TrmB k59_1710327_1 555793.WSK_2176 3.96e-57 181.0 COG0454@1|root,COG0456@2|Bacteria,1QTYD@1224|Proteobacteria,2TWX8@28211|Alphaproteobacteria,2K4KX@204457|Sphingomonadales 204457|Sphingomonadales K Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_1,Acetyltransf_7 k59_1710327_2 158500.BV97_02392 3.88e-30 116.0 COG0079@1|root,COG0079@2|Bacteria,1MW7I@1224|Proteobacteria,2TQPN@28211|Alphaproteobacteria,2JZXY@204457|Sphingomonadales 204457|Sphingomonadales E Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily hisC - 2.6.1.9 ko:K00817 ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230 M00026 R00694,R00734,R03243 RC00006,RC00888 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 k59_15631_1 158500.BV97_03459 2.38e-105 316.0 COG4638@1|root,COG4638@2|Bacteria,1R4IX@1224|Proteobacteria,2U511@28211|Alphaproteobacteria,2K30Q@204457|Sphingomonadales 204457|Sphingomonadales P PFAM Rieske 2Fe-2S domain - - - - - - - - - - - - Rieske,Ring_hydroxyl_A k59_1258151_1 1234595.C725_1374 3.65e-29 120.0 COG2902@1|root,COG2902@2|Bacteria,1MXNV@1224|Proteobacteria,2TS89@28211|Alphaproteobacteria,4BPMR@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria E Bacterial NAD-glutamate dehydrogenase gdhB GO:0003674,GO:0003824,GO:0004352,GO:0004353,GO:0008150,GO:0008152,GO:0016491,GO:0016638,GO:0016639,GO:0055114 1.4.1.2 ko:K15371 ko00220,ko00250,ko00430,ko00910,ko01100,map00220,map00250,map00430,map00910,map01100 - R00243 RC00006,RC02799 ko00000,ko00001,ko01000 - - - Bac_GDH k59_1541166_1 1206735.BAGG01000092_gene3710 9.69e-18 90.1 COG1012@1|root,COG1012@2|Bacteria,2GJ95@201174|Actinobacteria,4FWXS@85025|Nocardiaceae 201174|Actinobacteria C Aldehyde dehydrogenase family - - 1.2.99.10 ko:K22445 - - - - ko00000,ko01000 - - - Aldedh k59_1259384_1 1096930.L284_08205 2.88e-81 248.0 COG4395@1|root,COG4395@2|Bacteria,1NCIX@1224|Proteobacteria,2TTDQ@28211|Alphaproteobacteria,2K0UG@204457|Sphingomonadales 204457|Sphingomonadales S import inner membrane translocase, subunit Tim44 - - - - - - - - - - - - Tim44 k59_16872_1 479434.Sthe_1092 6.07e-28 117.0 COG0366@1|root,COG3281@1|root,COG0366@2|Bacteria,COG3281@2|Bacteria,2G86T@200795|Chloroflexi,27XQK@189775|Thermomicrobia 189775|Thermomicrobia G Alpha-amylase domain - - 3.2.1.1,5.4.99.16 ko:K05343 ko00500,ko01100,map00500,map01100 - R01557,R02108,R02112,R11262 RC01816 ko00000,ko00001,ko01000 - GH13 - APH,Alpha-amylase,Malt_amylase_C k59_186750_1 391589.RGAI101_4100 8.04e-35 128.0 COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,2TQQ7@28211|Alphaproteobacteria,2P2I7@2433|Roseobacter 28211|Alphaproteobacteria I Belongs to the thiolase family vraB - 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N k59_186750_2 1122137.AQXF01000002_gene471 2.41e-88 268.0 COG0604@1|root,COG0604@2|Bacteria,1MWRK@1224|Proteobacteria,2TQMF@28211|Alphaproteobacteria 28211|Alphaproteobacteria C COG0604 NADPH quinone reductase and related Zn-dependent oxidoreductases MA20_25320 - 1.1.1.1,1.6.5.5 ko:K00001,ko:K00344 ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220 - R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310 RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273 ko00000,ko00001,ko01000 - - - ADH_N,ADH_zinc_N k59_468566_1 1229909.NSED_01815 2.35e-14 68.9 arCOG08745@1|root,arCOG08745@2157|Archaea,41SU1@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_524514_1 1123376.AUIU01000012_gene1512 9.09e-45 165.0 COG0046@1|root,COG0047@1|root,COG0046@2|Bacteria,COG0047@2|Bacteria,3J0TJ@40117|Nitrospirae 40117|Nitrospirae F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL purL - 6.3.5.3 ko:K01952 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04463 RC00010,RC01160 ko00000,ko00001,ko00002,ko01000 - - - AIRS,AIRS_C,GATase_5 k59_1598471_5 292414.TM1040_0821 1.06e-24 110.0 COG3391@1|root,COG3391@2|Bacteria 2|Bacteria CO amine dehydrogenase activity - - - ko:K12287 - - - - ko00000,ko02044 - - - DUF11,VCBS k59_1598471_7 10754.VG16_BPP22 1.17e-29 132.0 4QEN7@10239|Viruses,4QW0U@35237|dsDNA viruses no RNA stage,4QSNP@28883|Caudovirales,4QNFM@10744|Podoviridae 10744|Podoviridae S viral entry into host cell - GO:0006810,GO:0008150,GO:0016032,GO:0019058,GO:0030260,GO:0039678,GO:0044403,GO:0044409,GO:0044419,GO:0044766,GO:0046718,GO:0046794,GO:0051179,GO:0051234,GO:0051701,GO:0051704,GO:0051806,GO:0051828,GO:0099002,GO:1902579 - - - - - - - - - - - k59_1598471_8 1156919.QWC_12603 2.63e-20 99.0 COG0741@1|root,COG0741@2|Bacteria,1N5XK@1224|Proteobacteria 1224|Proteobacteria M lytic transglycosylase activity - - - ko:K02395 - - - - ko00000,ko02035 - - - - k59_1598471_16 1211777.BN77_4169 2.51e-71 236.0 2C5GI@1|root,2Z8C1@2|Bacteria,1R8XM@1224|Proteobacteria,2TUME@28211|Alphaproteobacteria,4BJKS@82115|Rhizobiaceae 28211|Alphaproteobacteria S P22 coat protein - gene protein 5 - - - - - - - - - - - - P22_CoatProtein k59_1598471_18 1502851.FG93_01114 2.57e-113 364.0 COG3170@1|root,COG3170@2|Bacteria,1PMRN@1224|Proteobacteria,2VC7S@28211|Alphaproteobacteria,3K5GP@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria NU Tfp pilus assembly protein FimV - - - - - - - - - - - - - k59_1598471_19 1304878.AUGD01000002_gene1841 6.19e-102 310.0 COG5565@1|root,COG5565@2|Bacteria,1R6R3@1224|Proteobacteria,2U1P9@28211|Alphaproteobacteria 28211|Alphaproteobacteria S DNA packaging protein gp2 gp2 - - - - - - - - - - - Terminase_6,Terminase_6C k59_1598471_20 1082933.MEA186_10736 3.98e-84 253.0 COG5565@1|root,COG5565@2|Bacteria,1RHD5@1224|Proteobacteria,2UB9H@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Terminase-like family - - - - - - - - - - - - Terminase_6 k59_1598471_21 394.NGR_c11330 6.55e-25 98.6 2DTAB@1|root,33JEU@2|Bacteria,1NNYR@1224|Proteobacteria,2UKBA@28211|Alphaproteobacteria,4BG36@82115|Rhizobiaceae 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_1598471_23 1229204.AMYY01000059_gene2679 1.59e-13 67.0 2EK5N@1|root,33DW2@2|Bacteria,1NHDG@1224|Proteobacteria,2UJBG@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_367723_1 1122137.AQXF01000002_gene182 1.7e-106 320.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2TQW2@28211|Alphaproteobacteria 28211|Alphaproteobacteria T COG2204 Response regulator containing CheY-like receiver AAA-type ATPase and DNA-binding domains ntrX - - ko:K13599 ko02020,map02020 M00498 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_705609_1 1121004.ATVC01000005_gene1358 4.24e-95 295.0 COG0481@1|root,COG0481@2|Bacteria,1MVZA@1224|Proteobacteria,2VHM5@28216|Betaproteobacteria,2KPWD@206351|Neisseriales 206351|Neisseriales M Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner lepA - - ko:K03596 ko05134,map05134 - - - ko00000,ko00001 - - - EFG_C,GTP_EFTU,GTP_EFTU_D2,LepA_C k59_759419_1 292415.Tbd_0236 5.64e-59 194.0 COG1814@1|root,COG1814@2|Bacteria,1MUZE@1224|Proteobacteria,2VJ27@28216|Betaproteobacteria 28216|Betaproteobacteria S membrane - - - - - - - - - - - - VIT1 k59_85285_1 1174528.JH992892_gene6418 1.85e-182 528.0 COG3119@1|root,COG3119@2|Bacteria,1G3QV@1117|Cyanobacteria 1117|Cyanobacteria P COG3119 Arylsulfatase A and related enzymes - - 3.1.6.1 ko:K01130 ko00140,ko00600,map00140,map00600 - R03980,R04856 RC00128,RC00231 ko00000,ko00001,ko01000 - - - Sulfatase k59_1554101_1 1122137.AQXF01000004_gene1695 8.68e-07 49.7 COG0706@1|root,COG0706@2|Bacteria,1MV5M@1224|Proteobacteria,2TSTJ@28211|Alphaproteobacteria 28211|Alphaproteobacteria U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins yidC GO:0002790,GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0008565,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0032940,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944 - ko:K03217 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044,ko03029 2.A.9 - - 60KD_IMP,YidC_periplas k59_1554101_2 1122137.AQXF01000004_gene1694 9.69e-79 239.0 COG0218@1|root,COG0218@2|Bacteria,1MY3Z@1224|Proteobacteria,2U5E5@28211|Alphaproteobacteria 28211|Alphaproteobacteria D Necessary for normal cell division and for the maintenance of normal septation engB - - ko:K03978 - - - - ko00000,ko03036 - - - MMR_HSR1 k59_1213930_1 1229909.NSED_02150 3.38e-43 155.0 COG0674@1|root,arCOG01606@2157|Archaea,41S60@651137|Thaumarchaeota 651137|Thaumarchaeota C pyruvate flavodoxin ferredoxin oxidoreductase - - 1.2.7.11,1.2.7.3 ko:K00174 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - PFOR_II,POR,POR_N k59_1213930_2 1229909.NSED_02155 3.64e-204 568.0 COG1013@1|root,arCOG01599@2157|Archaea,41SAB@651137|Thaumarchaeota 651137|Thaumarchaeota C Pyruvate ferredoxin oxidoreductase beta subunit C terminal - - 1.2.7.11,1.2.7.3 ko:K00175 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - PFO_beta_C,TPP_enzyme_C k59_646777_1 1280390.CBQR020000036_gene811 6.56e-20 94.4 COG1017@1|root,COG1018@1|root,COG1017@2|Bacteria,COG1018@2|Bacteria,1TRG2@1239|Firmicutes,4HAU3@91061|Bacilli,26TT7@186822|Paenibacillaceae 91061|Bacilli C Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress hmp GO:0000041,GO:0000166,GO:0001505,GO:0003674,GO:0003824,GO:0004155,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0006826,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0008941,GO:0009056,GO:0009987,GO:0015669,GO:0015671,GO:0015893,GO:0016491,GO:0016645,GO:0016646,GO:0016705,GO:0016708,GO:0017144,GO:0019825,GO:0030001,GO:0033554,GO:0034641,GO:0036094,GO:0042133,GO:0042135,GO:0042221,GO:0042493,GO:0042737,GO:0043167,GO:0043168,GO:0044237,GO:0044248,GO:0044270,GO:0044464,GO:0046209,GO:0046210,GO:0048037,GO:0050660,GO:0050662,GO:0050896,GO:0051179,GO:0051213,GO:0051234,GO:0051409,GO:0051716,GO:0055114,GO:0065007,GO:0065008,GO:0071500,GO:0071949,GO:0072593,GO:0097159,GO:1901265,GO:1901363,GO:2001057 1.14.12.17,1.18.1.3 ko:K05916,ko:K15765 ko00623,ko00920,ko01100,ko01120,ko01220,ko05132,map00623,map00920,map01100,map01120,map01220,map05132 M00538 R02550,R03562,R05666,R09513 RC00269,RC00490,RC02556 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_6,Globin,NAD_binding_1 k59_477127_1 1442599.JAAN01000046_gene2751 2.75e-21 96.7 COG3712@1|root,COG3712@2|Bacteria,1MZCK@1224|Proteobacteria,1SYRC@1236|Gammaproteobacteria,1XCSV@135614|Xanthomonadales 135614|Xanthomonadales PT Domain of unknown function (DUF4880) - - - ko:K07165 - - - - ko00000 - - - DUF4880,FecR k59_1045767_1 637905.SVI_3846 3.51e-09 64.3 COG2304@1|root,COG2931@1|root,COG2304@2|Bacteria,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,1RNK8@1236|Gammaproteobacteria,2Q9AA@267890|Shewanellaceae 1236|Gammaproteobacteria Q Outer membrane adhesin like proteiin - - - - - - - - - - - - HemolysinCabind,VWA_2 k59_85295_1 396588.Tgr7_1276 2.55e-138 416.0 COG0068@1|root,COG0068@2|Bacteria,1MVP8@1224|Proteobacteria,1RP08@1236|Gammaproteobacteria,1WX2T@135613|Chromatiales 135613|Chromatiales O Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide - - - ko:K04656 - - - - ko00000 - - - Acylphosphatase,Sua5_yciO_yrdC,zf-HYPF k59_592318_1 436308.Nmar_1309 1.64e-106 327.0 COG1042@1|root,arCOG01338@2157|Archaea,arCOG01340@2157|Archaea,41S7I@651137|Thaumarchaeota 651137|Thaumarchaeota C Succinyl-CoA ligase like flavodoxin domain - - - ko:K18594 ko00720,ko01120,map00720,map01120 - R03157 RC00004,RC00014 ko00000,ko00001,ko01000 - - - ATP-grasp_5,CoA_binding_2,Succ_CoA_lig k59_592318_2 436308.Nmar_1308 1.77e-110 322.0 COG1024@1|root,arCOG00239@2157|Archaea,41SH7@651137|Thaumarchaeota 651137|Thaumarchaeota I Belongs to the enoyl-CoA hydratase isomerase family - - 4.2.1.116 ko:K15019 ko00720,ko01120,ko01200,map00720,map01120,map01200 M00375 R03045 RC00834 ko00000,ko00001,ko00002,ko01000 - - - ECH_1 k59_195408_1 1122137.AQXF01000002_gene430 1.45e-219 637.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2TQT0@28211|Alphaproteobacteria 28211|Alphaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K03296,ko:K18138 ko01501,ko01503,map01501,map01503 M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000 2.A.6.2 - - ACR_tran k59_646779_1 861299.J421_2762 1.55e-77 235.0 COG0250@1|root,COG0250@2|Bacteria,1ZSS2@142182|Gemmatimonadetes 142182|Gemmatimonadetes K Participates in transcription elongation, termination and antitermination nusG - - ko:K02601 - - - - ko00000,ko03009,ko03021 - - - NusG k59_1554116_1 199310.c1971 3.53e-65 209.0 COG4948@1|root,COG4948@2|Bacteria,1MURK@1224|Proteobacteria,1RNRB@1236|Gammaproteobacteria,3XP82@561|Escherichia 1236|Gammaproteobacteria M Has low D-mannonate dehydratase activity (in vitro), suggesting that this is not a physiological substrate and that it has no significant role in D-mannonate degradation in vivo. Has no detectable activity with a panel of 70 other acid sugars (in vitro) rspA GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005975,GO:0008150,GO:0008152,GO:0008927,GO:0009056,GO:0016052,GO:0016829,GO:0016835,GO:0016836,GO:0043167,GO:0043169,GO:0044238,GO:0046872,GO:0047929,GO:0071704,GO:1901575 4.2.1.8 ko:K08323 ko00040,ko01100,map00040,map01100 M00061 R05606 RC00543 ko00000,ko00001,ko00002,ko01000 - - - MR_MLE_C,MR_MLE_N k59_929242_1 316407.85677000 3.55e-51 179.0 2AUX4@1|root,31KKI@2|Bacteria,1QIG4@1224|Proteobacteria,1TGAH@1236|Gammaproteobacteria,3XQ8V@561|Escherichia 1236|Gammaproteobacteria - - yjgL - - - - - - - - - - - - k59_1156275_1 369723.Strop_4080 9.71e-55 183.0 COG0609@1|root,COG0609@2|Bacteria,2GK8Z@201174|Actinobacteria,4D9B0@85008|Micromonosporales 201174|Actinobacteria P Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily - - - ko:K02015 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko02000 3.A.1.14 - - FecCD k59_422745_2 330214.NIDE2086 3.99e-21 93.6 COG1074@1|root,COG1074@2|Bacteria,3J16M@40117|Nitrospirae 40117|Nitrospirae L PD-(D/E)XK nuclease superfamily - - - - - - - - - - - - PDDEXK_1,UvrD-helicase,UvrD_C k59_1611316_3 436308.Nmar_1761 6.44e-57 183.0 COG1878@1|root,arCOG02462@2157|Archaea,41SK8@651137|Thaumarchaeota 651137|Thaumarchaeota E Putative cyclase - - - - - - - - - - - - Cyclase k59_196977_1 521674.Plim_0240 5.48e-122 379.0 COG0612@1|root,COG0612@2|Bacteria,2IYKK@203682|Planctomycetes 203682|Planctomycetes S PFAM Peptidase M16 inactive domain - - - ko:K07263 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M16,Peptidase_M16_C k59_1326142_1 1163407.UU7_06888 2.95e-41 156.0 COG3391@1|root,COG4719@1|root,COG4932@1|root,COG3391@2|Bacteria,COG4719@2|Bacteria,COG4932@2|Bacteria,1QUEG@1224|Proteobacteria 1224|Proteobacteria M Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane - - 3.4.24.40 ko:K01406 ko01503,map01503 - - - ko00000,ko00001,ko01000,ko01002 - - - Cadherin,Cadherin_3,Calx-beta k59_1157808_1 1458427.BAWN01000029_gene1688 0.000145 41.6 COG2921@1|root,COG2921@2|Bacteria,1RGV5@1224|Proteobacteria,2VTY5@28216|Betaproteobacteria,4AEUT@80864|Comamonadaceae 28216|Betaproteobacteria S Belongs to the UPF0250 family ybeD - - ko:K09158 - - - - ko00000 - - - DUF493 k59_1157808_2 1323663.AROI01000004_gene2053 9.04e-39 143.0 COG1686@1|root,COG1686@2|Bacteria,1MUU7@1224|Proteobacteria,1RMJA@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Belongs to the peptidase S11 family dacA GO:0000270,GO:0003674,GO:0003824,GO:0004175,GO:0004180,GO:0004185,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006022,GO:0006023,GO:0006024,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0008238,GO:0008360,GO:0008658,GO:0009002,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016021,GO:0016787,GO:0017171,GO:0019538,GO:0022603,GO:0022604,GO:0030203,GO:0031224,GO:0031226,GO:0031406,GO:0033218,GO:0033293,GO:0034645,GO:0036094,GO:0042221,GO:0042493,GO:0042546,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051128,GO:0065007,GO:0065008,GO:0070008,GO:0070011,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:0097159,GO:0140096,GO:1901135,GO:1901137,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901681 3.4.16.4 ko:K07258 ko00550,ko01100,map00550,map01100 - - - ko00000,ko00001,ko01000,ko01002,ko01011 - - iEC55989_1330.EC55989_2269,iSFV_1184.SFV_0694,iSbBS512_1146.SbBS512_E2506,iYL1228.KPN_00664 PBP5_C,Peptidase_S11 k59_877676_1 436308.Nmar_0987 1.82e-177 498.0 COG1405@1|root,arCOG01981@2157|Archaea,41SYU@651137|Thaumarchaeota 651137|Thaumarchaeota K Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB) - - - ko:K03124 ko03022,ko05169,ko05203,map03022,map05169,map05203 - - - ko00000,ko00001,ko03021 - - - TFIIB,TF_Zn_Ribbon k59_877676_2 1229909.NSED_05700 4.62e-56 178.0 COG2236@1|root,arCOG00040@2157|Archaea,41TA1@651137|Thaumarchaeota 651137|Thaumarchaeota F phosphoribosyltransferase - - - ko:K07101 - - - - ko00000 - - - - k59_1269332_1 1085623.GNIT_1459 5.14e-52 186.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,463YW@72275|Alteromonadaceae 1236|Gammaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K03296 - - - - ko00000 2.A.6.2 - - ACR_tran k59_1047202_1 398527.Bphyt_1829 7.39e-91 278.0 COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2VHB0@28216|Betaproteobacteria,1K17R@119060|Burkholderiaceae 28216|Betaproteobacteria C PFAM L-carnitine dehydratase bile acid-inducible protein F frc_13 - 2.8.3.16 ko:K07749 - - - - ko00000,ko01000 - - - CoA_transf_3 k59_707235_1 1122137.AQXF01000004_gene1548 3.85e-175 501.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2TQPG@28211|Alphaproteobacteria 28211|Alphaproteobacteria T COG2204 Response regulator containing CheY-like receiver AAA-type ATPase and DNA-binding domains tacA GO:0003674,GO:0003700,GO:0004857,GO:0006355,GO:0008073,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0010967,GO:0019219,GO:0019222,GO:0030234,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0033238,GO:0042979,GO:0043086,GO:0044092,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050790,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0065009,GO:0080090,GO:0098772,GO:0140110,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141 - - - - - - - - - - HTH_8,Response_reg,Sigma54_activ_2,Sigma54_activat k59_1269333_1 1121921.KB898712_gene2187 1.18e-20 89.0 COG3201@1|root,COG3201@2|Bacteria,1MXN4@1224|Proteobacteria,1RMZE@1236|Gammaproteobacteria,2PNHM@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria H Nicotinamide mononucleotide transporter pnuC - - ko:K03811 - - - - ko00000,ko02000 4.B.1.1 - - NMN_transporter k59_1269333_2 1453501.JELR01000001_gene3107 1.98e-20 84.3 COG0011@1|root,COG0011@2|Bacteria,1N8R0@1224|Proteobacteria,1SCF3@1236|Gammaproteobacteria,468E8@72275|Alteromonadaceae 1236|Gammaproteobacteria S YKOF-related Family - - - - - - - - - - - - Thiamine_BP,Ykof k59_533687_1 504487.JCM19302_2955 4.38e-184 524.0 COG4799@1|root,COG4799@2|Bacteria,4NEMJ@976|Bacteroidetes,1HY0V@117743|Flavobacteriia 976|Bacteroidetes I Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) accD5 - - - - - - - - - - - Carboxyl_trans k59_533688_2 2074.JNYD01000019_gene2465 3.39e-10 60.8 COG0318@1|root,COG0318@2|Bacteria,2IA5S@201174|Actinobacteria,4E8RA@85010|Pseudonocardiales 201174|Actinobacteria IQ AMP-binding enzyme C-terminal domain - - - - - - - - - - - - AMP-binding,AMP-binding_C k59_312536_1 318996.AXAZ01000113_gene348 7.69e-63 205.0 COG0451@1|root,COG0451@2|Bacteria,1PB4Y@1224|Proteobacteria,2TTV7@28211|Alphaproteobacteria,3JWIV@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria M 3-beta hydroxysteroid dehydrogenase/isomerase family - - 5.1.3.2 ko:K01784 ko00052,ko00520,ko01100,map00052,map00520,map01100 M00361,M00362,M00632 R00291,R02984 RC00289 ko00000,ko00001,ko00002,ko01000 - - - Epimerase k59_1100329_1 1120972.AUMH01000001_gene1024 2.2e-104 318.0 COG2225@1|root,COG2225@2|Bacteria,1TPE8@1239|Firmicutes,4H9ST@91061|Bacilli,27820@186823|Alicyclobacillaceae 91061|Bacilli C Belongs to the malate synthase family aceB - 2.3.3.9 ko:K01638 ko00620,ko00630,ko01100,ko01110,ko01120,ko01200,map00620,map00630,map01100,map01110,map01120,map01200 M00012 R00472 RC00004,RC00308,RC02747 ko00000,ko00001,ko00002,ko01000 - - - Malate_synthase k59_1215580_1 1144305.PMI02_00793 7.77e-92 280.0 COG0706@1|root,COG0706@2|Bacteria,1MV5M@1224|Proteobacteria,2TSTJ@28211|Alphaproteobacteria,2K1E1@204457|Sphingomonadales 204457|Sphingomonadales U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins yidC - - ko:K03217 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044,ko03029 2.A.9 - - 60KD_IMP,YidC_periplas k59_1100332_1 997346.HMPREF9374_2222 1.73e-57 191.0 COG0148@1|root,COG0148@2|Bacteria,1TP2S@1239|Firmicutes,4HAKI@91061|Bacilli,27B4J@186824|Thermoactinomycetaceae 91061|Bacilli G Enolase, N-terminal domain eno GO:0001968,GO:0003674,GO:0003824,GO:0004634,GO:0005488,GO:0005515,GO:0005518,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009986,GO:0009987,GO:0016052,GO:0016053,GO:0016310,GO:0016829,GO:0016835,GO:0016836,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0019899,GO:0030312,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0035375,GO:0042866,GO:0043236,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0044877,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0050840,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0071944,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576 4.2.1.11 ko:K01689 ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066 M00001,M00002,M00003,M00346,M00394 R00658 RC00349 ko00000,ko00001,ko00002,ko01000,ko03019,ko04147 - - - Enolase_C,Enolase_N k59_86998_1 1336208.JADY01000010_gene3286 4.65e-36 141.0 COG0784@1|root,COG2203@1|root,COG4191@1|root,COG0784@2|Bacteria,COG2203@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TQQ9@28211|Alphaproteobacteria 28211|Alphaproteobacteria T Histidine kinase - - - - - - - - - - - - GAF,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg k59_986199_1 333138.LQ50_17405 4.79e-16 84.3 COG2239@1|root,COG2239@2|Bacteria,1TP4V@1239|Firmicutes,4HASP@91061|Bacilli,1ZCSG@1386|Bacillus 91061|Bacilli P Acts as a magnesium transporter mgtE - - ko:K06213 - - - - ko00000,ko02000 1.A.26.1 - iYO844.BSU13300 CBS,MgtE,MgtE_N k59_1499160_1 998674.ATTE01000001_gene2520 1.17e-74 230.0 COG1347@1|root,COG1347@2|Bacteria,1MUZR@1224|Proteobacteria,1RNFE@1236|Gammaproteobacteria,4602B@72273|Thiotrichales 72273|Thiotrichales C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol nqrD - 1.6.5.8 ko:K00349 - - - - ko00000,ko01000 - - - Rnf-Nqr k59_1157843_1 1151127.KB906328_gene2314 4.06e-12 66.6 COG2844@1|root,COG2844@2|Bacteria,1MV54@1224|Proteobacteria,1RN5T@1236|Gammaproteobacteria,1YMTE@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria O Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen glnD GO:0003674,GO:0003824,GO:0006082,GO:0006464,GO:0006520,GO:0006541,GO:0006542,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008773,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016740,GO:0016772,GO:0016779,GO:0019538,GO:0019752,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044283,GO:0046394,GO:0070569,GO:0071704,GO:0140096,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.7.59 ko:K00990 ko02020,map02020 - - - ko00000,ko00001,ko01000 - - - ACT,GlnD_UR_UTase,HD,NTP_transf_2 k59_1157843_2 1249627.D779_3217 1.03e-48 167.0 COG0436@1|root,COG0436@2|Bacteria,1MWS8@1224|Proteobacteria,1RPGJ@1236|Gammaproteobacteria,1WWET@135613|Chromatiales 135613|Chromatiales E PFAM Aminotransferase class I and II - - 2.6.1.17 ko:K14267 ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230 M00016 R04475 RC00006 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 k59_1326173_1 126957.SMAR014483-PA 5.35e-08 56.2 COG0204@1|root,COG2759@1|root,COG4229@1|root,KOG1505@2759|Eukaryota,KOG2630@2759|Eukaryota,KOG4230@2759|Eukaryota,38DB3@33154|Opisthokonta,3BBBH@33208|Metazoa,3CTTH@33213|Bilateria,41TMJ@6656|Arthropoda 33208|Metazoa H methylenetetrahydrofolate dehydrogenase (NADP ) activity. It is involved in the biological process described with folic acid-containing compound biosynthetic process MTHFD1 GO:0000096,GO:0000097,GO:0000166,GO:0001501,GO:0001776,GO:0001780,GO:0001838,GO:0001841,GO:0001843,GO:0002009,GO:0002262,GO:0002376,GO:0003674,GO:0003824,GO:0004329,GO:0004477,GO:0004486,GO:0004487,GO:0004488,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0005829,GO:0006082,GO:0006139,GO:0006144,GO:0006163,GO:0006164,GO:0006520,GO:0006534,GO:0006555,GO:0006575,GO:0006725,GO:0006730,GO:0006732,GO:0006753,GO:0006760,GO:0006766,GO:0006767,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0007275,GO:0007399,GO:0007507,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009070,GO:0009086,GO:0009092,GO:0009108,GO:0009112,GO:0009113,GO:0009117,GO:0009165,GO:0009256,GO:0009257,GO:0009396,GO:0009653,GO:0009790,GO:0009792,GO:0009887,GO:0009888,GO:0009987,GO:0010035,GO:0014020,GO:0015942,GO:0016053,GO:0016331,GO:0016491,GO:0016645,GO:0016646,GO:0016787,GO:0016810,GO:0016814,GO:0016874,GO:0016879,GO:0016999,GO:0017076,GO:0017144,GO:0018130,GO:0019238,GO:0019346,GO:0019438,GO:0019637,GO:0019752,GO:0021915,GO:0030554,GO:0031974,GO:0032501,GO:0032502,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0034641,GO:0034654,GO:0035148,GO:0035239,GO:0035295,GO:0035639,GO:0035713,GO:0035999,GO:0036094,GO:0042221,GO:0042398,GO:0042440,GO:0042558,GO:0042559,GO:0042592,GO:0042802,GO:0042803,GO:0043009,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0043603,GO:0043604,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046112,GO:0046148,GO:0046394,GO:0046483,GO:0046653,GO:0046654,GO:0046655,GO:0046983,GO:0048513,GO:0048562,GO:0048568,GO:0048598,GO:0048646,GO:0048701,GO:0048702,GO:0048703,GO:0048704,GO:0048705,GO:0048706,GO:0048729,GO:0048731,GO:0048856,GO:0048872,GO:0050667,GO:0050896,GO:0051186,GO:0051188,GO:0055086,GO:0055114,GO:0060429,GO:0060562,GO:0060606,GO:0061053,GO:0065007,GO:0065008,GO:0070013,GO:0071704,GO:0072175,GO:0072359,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1901698,GO:1901700,GO:1904888 1.5.1.15,1.5.1.5,3.5.4.9,6.3.4.3 ko:K00288,ko:K13402,ko:K13403 ko00670,ko01100,map00670,map01100 M00141 R00943,R01218,R01220,R01655 RC00026,RC00111,RC00202,RC00578 ko00000,ko00001,ko00002,ko01000,ko04147 - - - FTHFS,THF_DHG_CYH,THF_DHG_CYH_C k59_1326173_2 697282.Mettu_2015 2.49e-73 224.0 COG1791@1|root,COG1791@2|Bacteria,1RCZD@1224|Proteobacteria,1S42U@1236|Gammaproteobacteria,1XF09@135618|Methylococcales 135618|Methylococcales S Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway mtnD - 1.13.11.53,1.13.11.54 ko:K08967 ko00270,ko01100,map00270,map01100 M00034 R07363,R07364 RC01866,RC02018,RC02118 ko00000,ko00001,ko00002,ko01000 - - - ARD k59_478406_1 68199.JNZO01000025_gene5832 1.21e-72 236.0 COG4626@1|root,COG4626@2|Bacteria,2GNSB@201174|Actinobacteria 201174|Actinobacteria S Terminase - - - - - - - - - - - - - k59_1157844_2 272123.Anacy_3259 1.03e-33 133.0 COG2199@1|root,COG3706@2|Bacteria,1G35Y@1117|Cyanobacteria 1117|Cyanobacteria T COG3706 Response regulator containing a CheY-like receiver domain and a GGDEF domain - - 2.7.7.65 ko:K21020 ko02025,map02025 - - - ko00000,ko00001,ko01000 - - - GGDEF,Response_reg k59_1499168_1 1380391.JIAS01000012_gene3985 4.47e-79 247.0 COG1948@1|root,COG5276@1|root,COG4880@2|Bacteria,COG5276@2|Bacteria,1MU72@1224|Proteobacteria,2TZVG@28211|Alphaproteobacteria,2JUDH@204441|Rhodospirillales 204441|Rhodospirillales L Secreted protein containing C-terminal beta-propeller domain distantly related to WD-40 repeats - - - - - - - - - - - - LVIVD k59_1611359_1 595537.Varpa_5410 1.42e-05 48.9 COG1028@1|root,COG1028@2|Bacteria,1MX30@1224|Proteobacteria,2VNV9@28216|Betaproteobacteria,4ADT3@80864|Comamonadaceae 28216|Betaproteobacteria IQ PFAM Short-chain dehydrogenase reductase SDR - - - - - - - - - - - - adh_short_C2 k59_1611359_2 876044.IMCC3088_2216 1.02e-13 70.1 COG0583@1|root,COG0583@2|Bacteria,1MWY0@1224|Proteobacteria,1RP7Q@1236|Gammaproteobacteria,1JAQV@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria K LysR substrate binding domain ampR - - ko:K03566,ko:K17850 ko01501,ko02026,map01501,map02026 M00628 - - ko00000,ko00001,ko00002,ko03000 - - - HTH_1,LysR_substrate k59_312566_1 1282876.BAOK01000001_gene2489 2.95e-65 211.0 COG1804@1|root,COG1804@2|Bacteria,1MVY1@1224|Proteobacteria,2TVJ9@28211|Alphaproteobacteria,4BT9Y@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria C CoA-transferase family III - - - - - - - - - - - - CoA_transf_3 k59_312566_2 153721.MYP_4131 1.4e-17 82.0 COG0473@1|root,COG0473@2|Bacteria,4NGUA@976|Bacteroidetes,47KD2@768503|Cytophagia 976|Bacteroidetes CE Isocitrate dehydrogenase - - 1.1.1.41,1.1.1.85 ko:K00030,ko:K00052 ko00020,ko00290,ko00660,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00290,map00660,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00432,M00535 R00709,R00994,R04426,R10052 RC00084,RC00114,RC00417,RC03036 br01601,ko00000,ko00001,ko00002,ko01000 - - - Iso_dh k59_422791_1 316407.21321965 3.57e-35 131.0 COG0768@1|root,COG0768@2|Bacteria,1MUNY@1224|Proteobacteria,1RNGW@1236|Gammaproteobacteria,3XM4D@561|Escherichia 1236|Gammaproteobacteria M of the peptidoglycan cell wall at the division septum ftsI GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008144,GO:0008150,GO:0008658,GO:0008955,GO:0009987,GO:0016020,GO:0016021,GO:0016740,GO:0016757,GO:0016758,GO:0031224,GO:0031226,GO:0031406,GO:0032153,GO:0033218,GO:0033293,GO:0036094,GO:0042221,GO:0042493,GO:0043167,GO:0043168,GO:0043177,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051301,GO:0071944,GO:0097159,GO:1901363,GO:1901681 3.4.16.4 ko:K03587 ko00550,ko01501,map00550,map01501 - - - ko00000,ko00001,ko01000,ko01011,ko03036 - - iSSON_1240.SSON_0092 PBP_dimer,Transpeptidase k59_422791_2 316407.85674321 1.01e-78 234.0 COG3116@1|root,COG3116@2|Bacteria,1N9MH@1224|Proteobacteria,1SC7P@1236|Gammaproteobacteria,3XPMD@561|Escherichia 1236|Gammaproteobacteria D Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic ftsL GO:0000003,GO:0000910,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0007049,GO:0008150,GO:0009987,GO:0016020,GO:0016021,GO:0019954,GO:0022402,GO:0022414,GO:0031224,GO:0031226,GO:0032153,GO:0032505,GO:0043093,GO:0044425,GO:0044459,GO:0044464,GO:0051301,GO:0071944 - ko:K03586 - - - - ko00000,ko03036 - - - FtsL k59_1499176_1 436308.Nmar_0471 6.23e-96 302.0 COG1948@1|root,arCOG02284@2157|Archaea,41T0R@651137|Thaumarchaeota 651137|Thaumarchaeota L Beta propeller domain - - - - - - - - - - - - Beta_propel k59_1555937_1 876269.ARWA01000001_gene912 1.64e-95 303.0 COG0187@1|root,COG0187@2|Bacteria,1MVKT@1224|Proteobacteria,2TRBK@28211|Alphaproteobacteria,3NA4N@45404|Beijerinckiaceae 28211|Alphaproteobacteria L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrB - 5.99.1.3 ko:K02470 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim k59_254713_1 34506.g5664 9.53e-62 214.0 COG0016@1|root,COG0072@1|root,KOG2472@2759|Eukaryota,KOG2784@2759|Eukaryota,3A7RT@33154|Opisthokonta,3BXEE@33208|Metazoa,3DEU8@33213|Bilateria 33208|Metazoa J tRNA synthetase B5 domain - - - - - - - - - - - - B3_4,B5,FDX-ACB,tRNA_bind k59_594029_1 1479239.JQMU01000001_gene1640 1.15e-76 252.0 COG0249@1|root,COG0249@2|Bacteria,1MUGX@1224|Proteobacteria,2TQRR@28211|Alphaproteobacteria,2K09S@204457|Sphingomonadales 204457|Sphingomonadales L that it carries out the mismatch recognition step. This protein has a weak ATPase activity mutS - - ko:K03555 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V k59_1047237_1 1077972.ARGLB_035_00140 3.1e-33 128.0 COG3621@1|root,COG3621@2|Bacteria,2I97F@201174|Actinobacteria,1WAYR@1268|Micrococcaceae 201174|Actinobacteria S Patatin-like phospholipase - - - - - - - - - - - - Patatin k59_877743_1 1229909.NSED_00070 3.82e-97 306.0 COG1287@1|root,arCOG02044@2157|Archaea,41SBI@651137|Thaumarchaeota 651137|Thaumarchaeota G Oligosaccharyl transferase STT3 subunit - - 2.4.99.18 ko:K07151 ko00510,ko00513,ko01100,ko04141,map00510,map00513,map01100,map04141 M00072 R04216,R05976 RC00005,RC00482 ko00000,ko00001,ko00002,ko01000,ko01003 - GT66 - STT3 k59_422801_1 1042377.AFPJ01000009_gene224 2.16e-117 351.0 COG0591@1|root,COG0591@2|Bacteria,1R4VK@1224|Proteobacteria,1RQFS@1236|Gammaproteobacteria,464TB@72275|Alteromonadaceae 1236|Gammaproteobacteria E Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family nanT - - ko:K03307 - - - - ko00000 2.A.21 - - SSF k59_986236_1 231434.JQJH01000011_gene3143 1.48e-57 192.0 COG0582@1|root,COG0582@2|Bacteria,1MU23@1224|Proteobacteria,2TS2G@28211|Alphaproteobacteria,3NBGX@45404|Beijerinckiaceae 28211|Alphaproteobacteria L Pfam:DUF4102 intB - - - - - - - - - - - Arm-DNA-bind_3,Phage_integrase k59_478424_1 1122137.AQXF01000002_gene403 1.65e-49 168.0 COG1652@1|root,COG1652@2|Bacteria,1MWMR@1224|Proteobacteria,2U7UH@28211|Alphaproteobacteria 28211|Alphaproteobacteria M protein containing LysM domain lysM - - - - - - - - - - - LysM k59_478424_3 1122137.AQXF01000002_gene401 1.84e-41 141.0 COG0688@1|root,COG0688@2|Bacteria,1MW45@1224|Proteobacteria,2TRMG@28211|Alphaproteobacteria 28211|Alphaproteobacteria I Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer) psd - 4.1.1.65 ko:K01613 ko00564,ko01100,ko01110,map00564,map01100,map01110 M00093 R02055 RC00299 ko00000,ko00001,ko00002,ko01000 - - - PS_Dcarbxylase k59_1499199_1 1229909.NSED_08845 6.63e-59 195.0 arCOG08733@1|root,arCOG08733@2157|Archaea,41SRN@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_533728_1 1123400.KB904748_gene333 5.7e-23 96.3 COG4302@1|root,COG4302@2|Bacteria,1MWQI@1224|Proteobacteria,1RQ2T@1236|Gammaproteobacteria 1236|Gammaproteobacteria E Belongs to the EutC family eutC - 4.3.1.7 ko:K03736 ko00564,ko01100,map00564,map01100 - R00749 RC00370 ko00000,ko00001,ko01000 - - - EutC k59_533728_2 400668.Mmwyl1_0477 1.83e-36 135.0 COG4303@1|root,COG4303@2|Bacteria,1MUR4@1224|Proteobacteria,1RPN8@1236|Gammaproteobacteria,1XIY4@135619|Oceanospirillales 135619|Oceanospirillales E With EutC catalyzes the formation of acetaldehyde and ammonia from ethanolamine - - 4.3.1.7 ko:K03735 ko00564,ko01100,map00564,map01100 - R00749 RC00370 ko00000,ko00001,ko01000 - - - EutB k59_760677_1 1392838.AWNM01000010_gene2152 2.01e-122 362.0 COG0141@1|root,COG0141@2|Bacteria,1MUUF@1224|Proteobacteria,2VJ7K@28216|Betaproteobacteria,3T2YB@506|Alcaligenaceae 28216|Betaproteobacteria E Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine hisD GO:0000105,GO:0003674,GO:0003824,GO:0004399,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019752,GO:0030145,GO:0034641,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046872,GO:0046914,GO:0052803,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.23 ko:K00013 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R01158,R01163,R03012 RC00099,RC00242,RC00463 ko00000,ko00001,ko00002,ko01000 - - - Histidinol_dh k59_877759_1 1122137.AQXF01000002_gene307 2.68e-72 227.0 COG0150@1|root,COG0150@2|Bacteria,1MURG@1224|Proteobacteria,2TR6G@28211|Alphaproteobacteria 28211|Alphaproteobacteria F Phosphoribosylformylglycinamidine cyclo-ligase purM - 6.3.3.1 ko:K01933 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04208 RC01100 ko00000,ko00001,ko00002,ko01000 - - - AIRS,AIRS_C k59_877759_2 1122137.AQXF01000002_gene306 7.07e-112 337.0 COG3249@1|root,COG3249@2|Bacteria 2|Bacteria S Uncharacterized protein conserved in bacteria (DUF2066) VV2512 - - ko:K09938 - - - - ko00000 - - - DUF2066 k59_877759_3 1101190.ARWB01000001_gene1091 5.68e-12 69.3 COG0628@1|root,COG0628@2|Bacteria,1MW0B@1224|Proteobacteria,2TRD3@28211|Alphaproteobacteria,36XIX@31993|Methylocystaceae 28211|Alphaproteobacteria S AI-2E family transporter perM - - ko:K03548 - - - - ko00000,ko02000 2.A.86.1 - - AI-2E_transport k59_1157892_1 1047013.AQSP01000115_gene341 2.61e-28 116.0 COG0673@1|root,COG0673@2|Bacteria,2NQ5E@2323|unclassified Bacteria 2|Bacteria S Oxidoreductase family, NAD-binding Rossmann fold - - - - - - - - - - - - GFO_IDH_MocA,GFO_IDH_MocA_C k59_478439_1 1313172.YM304_17300 3.49e-97 295.0 COG0427@1|root,COG0427@2|Bacteria,2IAMG@201174|Actinobacteria,4CNYP@84992|Acidimicrobiia 84992|Acidimicrobiia C Acetyl-CoA hydrolase/transferase C-terminal domain - - - - - - - - - - - - AcetylCoA_hyd_C k59_1326213_2 762376.AXYL_03703 5.19e-14 73.2 COG2843@1|root,COG2843@2|Bacteria,1P1MG@1224|Proteobacteria 1224|Proteobacteria M Capsule synthesis protein - - - ko:K07282 - - - - ko00000 - - - PGA_cap k59_1215663_1 314275.MADE_1001145 2.11e-77 246.0 COG4146@1|root,COG4146@2|Bacteria,1MXWV@1224|Proteobacteria,1RR4S@1236|Gammaproteobacteria,463ZX@72275|Alteromonadaceae 1236|Gammaproteobacteria S Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family sglT - - ko:K03307 - - - - ko00000 2.A.21 - - SSF k59_1724074_1 1500257.JQNM01000015_gene3065 2.04e-96 293.0 COG0683@1|root,COG0683@2|Bacteria,1R548@1224|Proteobacteria,2U48S@28211|Alphaproteobacteria,4BNDZ@82115|Rhizobiaceae 28211|Alphaproteobacteria E Periplasmic binding protein domain - - - ko:K01999 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - Peripla_BP_6 k59_1555989_2 1121937.AUHJ01000002_gene3469 5.11e-64 206.0 COG0821@1|root,COG0821@2|Bacteria,1MUAX@1224|Proteobacteria,1RMXZ@1236|Gammaproteobacteria,464MT@72275|Alteromonadaceae 1236|Gammaproteobacteria I Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate ispG GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016491,GO:0016725,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0032787,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046429,GO:0046490,GO:0046872,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0052592,GO:0055114,GO:0071704,GO:0090407,GO:1901135,GO:1901576 1.17.7.1,1.17.7.3 ko:K03526 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R08689,R10859 RC01486 ko00000,ko00001,ko00002,ko01000 - - iAF1260.b2515,iAPECO1_1312.APECO1_4009,iB21_1397.B21_02369,iBWG_1329.BWG_2279,iE2348C_1286.E2348C_2798,iEC55989_1330.EC55989_2800,iECABU_c1320.ECABU_c28200,iECBD_1354.ECBD_1171,iECB_1328.ECB_02407,iECDH10B_1368.ECDH10B_2681,iECDH1ME8569_1439.ECDH1ME8569_2442,iECDH1ME8569_1439.EcDH1_1153,iECD_1391.ECD_02407,iECED1_1282.ECED1_2946,iECH74115_1262.ECH74115_3740,iECIAI39_1322.ECIAI39_2716,iECNA114_1301.ECNA114_2593,iECO103_1326.ECO103_3032,iECO111_1330.ECO111_3239,iECO26_1355.ECO26_3562,iECOK1_1307.ECOK1_2863,iECP_1309.ECP_2520,iECS88_1305.ECS88_2691,iECSE_1348.ECSE_2801,iECSF_1327.ECSF_2359,iECSP_1301.ECSP_3455,iECW_1372.ECW_m2740,iECs_1301.ECs3377,iEKO11_1354.EKO11_1218,iETEC_1333.ETEC_2672,iEcDH1_1363.EcDH1_1153,iEcE24377_1341.EcE24377A_2799,iEcolC_1368.EcolC_1162,iJO1366.b2515,iJR904.b2515,iLF82_1304.LF82_1130,iNRG857_1313.NRG857_12515,iUMN146_1321.UM146_04130,iUMNK88_1353.UMNK88_3165,iUTI89_1310.UTI89_C2836,iWFL_1372.ECW_m2740,iY75_1357.Y75_RS13130,iYL1228.KPN_02845,iZ_1308.Z3778,ic_1306.c3037 GcpE k59_533748_1 936455.KI421499_gene69 3.96e-81 250.0 COG2084@1|root,COG2084@2|Bacteria,1MV48@1224|Proteobacteria,2U0FZ@28211|Alphaproteobacteria,3JVBH@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria I NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase - - 1.1.1.31 ko:K00020 ko00280,ko01100,map00280,map01100 - R05066 RC00099 ko00000,ko00001,ko01000 - - - NAD_binding_11,NAD_binding_2 k59_1100393_1 1150626.PHAMO_320072 3.97e-33 130.0 COG2271@1|root,COG2271@2|Bacteria,1QUF4@1224|Proteobacteria,2TW2A@28211|Alphaproteobacteria,2JYUN@204441|Rhodospirillales 204441|Rhodospirillales G COG0477 Permeases of the major facilitator superfamily - - - ko:K08218 ko01501,map01501 M00628 - - ko00000,ko00001,ko00002,ko02000 2.A.1.25 - - Acatn,MFS_1 k59_1326223_1 1484460.JSWG01000001_gene2443 4.77e-33 127.0 COG3420@1|root,COG5295@1|root,COG3420@2|Bacteria,COG5295@2|Bacteria,4NJTK@976|Bacteroidetes,1HZNB@117743|Flavobacteriia 976|Bacteroidetes UW surface antigen - - - - - - - - - - - - Peptidase_S74,YadA_head k59_1326223_2 1484460.JSWG01000001_gene2442 1.93e-41 151.0 COG0457@1|root,COG4585@1|root,COG0457@2|Bacteria,COG4585@2|Bacteria,4NI65@976|Bacteroidetes,1HX4T@117743|Flavobacteriia 976|Bacteroidetes T Histidine kinase - - - - - - - - - - - - HATPase_c,HisKA_3,TPR_12 k59_141967_1 876269.ARWA01000001_gene2004 5.4e-117 352.0 COG1233@1|root,COG1233@2|Bacteria,1MV2R@1224|Proteobacteria,2TSR0@28211|Alphaproteobacteria,3NCSI@45404|Beijerinckiaceae 28211|Alphaproteobacteria Q Flavin containing amine oxidoreductase MA20_01895 - 1.3.99.27 ko:K09845 ko00906,ko01100,map00906,map01100 - R07517,R07520,R07523,R07534 RC02080 ko00000,ko00001,ko01000 - - - Amino_oxidase k59_719573_2 203122.Sde_2221 1.14e-16 78.6 COG0535@1|root,COG0535@2|Bacteria,1MU07@1224|Proteobacteria,1RN94@1236|Gammaproteobacteria,465Z3@72275|Alteromonadaceae 1236|Gammaproteobacteria S Protein of unknown function (DUF3641) - - - - - - - - - - - - DUF3641,Fer4_12,Radical_SAM k59_940767_1 1122137.AQXF01000001_gene3364 5.43e-106 317.0 COG0583@1|root,COG0583@2|Bacteria,1MW16@1224|Proteobacteria,2TRIG@28211|Alphaproteobacteria 28211|Alphaproteobacteria K transcriptional regulator - - - - - - - - - - - - HTH_1,LysR_substrate k59_940767_2 1380387.JADM01000004_gene2958 9.88e-52 172.0 COG0435@1|root,COG0435@2|Bacteria,1MV50@1224|Proteobacteria,1RMTI@1236|Gammaproteobacteria,1XI2Z@135619|Oceanospirillales 135619|Oceanospirillales O Glutathione S-transferase - - 1.8.5.7 ko:K07393 - - - - ko00000,ko01000 - - - GST_C_2,GST_N_2 k59_1510759_1 1122137.AQXF01000001_gene2966 1.23e-185 523.0 COG0499@1|root,COG0499@2|Bacteria,1MUQ2@1224|Proteobacteria,2TSJY@28211|Alphaproteobacteria 28211|Alphaproteobacteria H May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine ahcY GO:0000096,GO:0003674,GO:0003824,GO:0004013,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006534,GO:0006555,GO:0006575,GO:0006725,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009066,GO:0009069,GO:0009116,GO:0009119,GO:0009987,GO:0016787,GO:0016801,GO:0016802,GO:0017144,GO:0019752,GO:0033353,GO:0034641,GO:0042278,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046128,GO:0046439,GO:0046483,GO:0046498,GO:0046500,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564,GO:1901605,GO:1901657 3.3.1.1 ko:K01251 ko00270,ko01100,map00270,map01100 M00035 R00192,R04936 RC00056,RC00069,RC01161,RC01243 ko00000,ko00001,ko00002,ko01000,ko01009,ko04147 - - - AdoHcyase,AdoHcyase_NAD k59_1057862_1 522306.CAP2UW1_1114 9.21e-42 150.0 COG5473@1|root,COG5473@2|Bacteria,1N9UJ@1224|Proteobacteria,2VRZ3@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_770490_1 485915.Dret_2520 6.09e-56 187.0 COG2801@1|root,COG2801@2|Bacteria,1R471@1224|Proteobacteria,42QU7@68525|delta/epsilon subdivisions,2WMSX@28221|Deltaproteobacteria,2MGUC@213115|Desulfovibrionales 28221|Deltaproteobacteria L Integrase core domain - - - - - - - - - - - - HTH_21,rve,rve_3 k59_719579_1 743299.Acife_2001 4.21e-82 250.0 COG2227@1|root,COG2227@2|Bacteria,1MU89@1224|Proteobacteria,1RMV7@1236|Gammaproteobacteria,2NC4E@225057|Acidithiobacillales 225057|Acidithiobacillales H O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway ubiG - 2.1.1.222,2.1.1.64 ko:K00568 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00117 R04988,R05614,R08769,R08781 RC00003,RC00392,RC01895 ko00000,ko00001,ko00002,ko01000 - - - Methyltransf_11,Methyltransf_23 k59_719579_2 686340.Metal_1461 1.41e-30 119.0 COG0402@1|root,COG0402@2|Bacteria,1MVPA@1224|Proteobacteria,1RN13@1236|Gammaproteobacteria,1XEMS@135618|Methylococcales 135618|Methylococcales F Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine mtaD - 3.5.4.28,3.5.4.31 ko:K12960 ko00270,ko01100,map00270,map01100 - R09660 RC00477 ko00000,ko00001,ko01000 - - - Amidohydro_1 k59_1733816_1 237609.PSAKL28_03680 2.4e-37 135.0 COG0625@1|root,COG0625@2|Bacteria,1RHSK@1224|Proteobacteria,1S7VQ@1236|Gammaproteobacteria 1236|Gammaproteobacteria O Glutathione S-Transferase yibF - - - - - - - - - - - GST_C_2,GST_N_3 k59_1169719_1 1101195.Meth11DRAFT_1125 3.62e-72 238.0 COG1298@1|root,COG1298@2|Bacteria,1MUF3@1224|Proteobacteria,2VHVC@28216|Betaproteobacteria,2KKSD@206350|Nitrosomonadales 28216|Betaproteobacteria N Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin flhA - - ko:K02400 ko02040,map02040 - - - ko00000,ko00001,ko02035,ko02044 3.A.6.2,3.A.6.3 - - FHIPEP k59_719585_1 436308.Nmar_1414 2.53e-56 181.0 arCOG08774@1|root,arCOG08774@2157|Archaea,41T7U@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_719585_2 436308.Nmar_1415 8.11e-76 237.0 COG2237@1|root,arCOG04151@2157|Archaea,41SA3@651137|Thaumarchaeota 651137|Thaumarchaeota S Domain of unknown function (DUF373) - - - ko:K08975 - - - - ko00000 - - - DUF373 k59_1110601_1 404589.Anae109_1258 2.38e-45 160.0 COG0114@1|root,COG0114@2|Bacteria,1MUQI@1224|Proteobacteria,43BJP@68525|delta/epsilon subdivisions,2WJWZ@28221|Deltaproteobacteria,2YUKJ@29|Myxococcales 28221|Deltaproteobacteria C Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate fumC - 4.2.1.2,4.3.1.1 ko:K01679,ko:K01744 ko00020,ko00250,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04934,ko05200,ko05211,map00020,map00250,map00620,map00720,map01100,map01110,map01120,map01130,map01200,map04934,map05200,map05211 M00009,M00011,M00173,M00376 R00490,R01082 RC00316,RC00443,RC02799 ko00000,ko00001,ko00002,ko01000 - - - FumaraseC_C,Lyase_1 k59_543167_1 189753.AXAS01000075_gene6010 9.59e-95 291.0 COG3666@1|root,COG3666@2|Bacteria,1N3QR@1224|Proteobacteria,2TRXG@28211|Alphaproteobacteria,3JVHX@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria L Transposase - - - ko:K07487 - - - - ko00000 - - - DDE_Tnp_1,DDE_Tnp_1_6,DUF772 k59_1785733_1 522373.Smlt4572 2.41e-54 179.0 COG0204@1|root,COG0204@2|Bacteria,1RDN7@1224|Proteobacteria,1S4Z5@1236|Gammaproteobacteria,1X4GD@135614|Xanthomonadales 135614|Xanthomonadales I Phosphate acyltransferases - - - - - - - - - - - - Acyltransferase k59_1397863_1 402626.Rpic_3132 8.27e-64 217.0 COG3975@1|root,COG3975@2|Bacteria,1MUHZ@1224|Proteobacteria,2VH5R@28216|Betaproteobacteria,1JZW4@119060|Burkholderiaceae 28216|Betaproteobacteria S Peptidase M61 - - - - - - - - - - - - PDZ_2,Peptidase_M61 k59_266524_1 316407.85676991 2.65e-121 370.0 COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,1RMYC@1236|Gammaproteobacteria,3XNGR@561|Escherichia 1236|Gammaproteobacteria P Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIB subfamily mgtA GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008324,GO:0015075,GO:0015318,GO:0015399,GO:0015405,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0031224,GO:0031226,GO:0034220,GO:0042623,GO:0042625,GO:0042626,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043492,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0090662,GO:0098655,GO:0098660,GO:0099131,GO:0099132 3.6.3.2 ko:K01531,ko:K12955 - - - - ko00000,ko01000 3.A.3.24,3.A.3.4 - iSF_1195.SF4248 Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase k59_1335851_1 479432.Sros_0735 7.15e-20 99.4 COG2909@1|root,COG3629@1|root,COG2909@2|Bacteria,COG3629@2|Bacteria,2GJAR@201174|Actinobacteria,4EHMH@85012|Streptosporangiales 201174|Actinobacteria KT Bacterial transcriptional activator domain - - - - - - - - - - - - AAA_16,BTAD,Trans_reg_C k59_1279170_1 1122137.AQXF01000001_gene2701 6.12e-68 212.0 COG4961@1|root,COG4961@2|Bacteria,1N0M1@1224|Proteobacteria,2UCUG@28211|Alphaproteobacteria 28211|Alphaproteobacteria U Flp pilus assembly protein TadG - - - - - - - - - - - - TadE k59_1279170_2 1122137.AQXF01000001_gene2700 3.42e-82 256.0 COG4961@1|root,COG4961@2|Bacteria,1MWXU@1224|Proteobacteria,2TRQP@28211|Alphaproteobacteria 28211|Alphaproteobacteria U Flp pilus assembly protein TadG - - - - - - - - - - - - Tad k59_543172_2 1123360.thalar_01367 6.9e-42 150.0 COG0471@1|root,COG0471@2|Bacteria,1MUSA@1224|Proteobacteria,2TU0C@28211|Alphaproteobacteria 28211|Alphaproteobacteria P COG0471 Di- and tricarboxylate transporters - - - ko:K03319,ko:K09477,ko:K11106,ko:K14445 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.47,2.A.47.1,2.A.47.3.2,2.A.47.3.3 - - Na_sulph_symp k59_1568374_1 1397666.RS24_00331 6.97e-05 52.4 COG4206@1|root,COG4206@2|Bacteria,1QVV2@1224|Proteobacteria,2UNU8@28211|Alphaproteobacteria 28211|Alphaproteobacteria P TonB dependent receptor - - - - - - - - - - - - Plug,TonB_dep_Rec k59_381185_1 1144305.PMI02_04243 1.7e-32 128.0 COG2972@1|root,COG2972@2|Bacteria,1MXVQ@1224|Proteobacteria,2U103@28211|Alphaproteobacteria,2K0W4@204457|Sphingomonadales 204457|Sphingomonadales T Histidine kinase - - - - - - - - - - - - HATPase_c,His_kinase k59_889665_1 436308.Nmar_1073 6.38e-11 68.2 COG3794@1|root,arCOG05978@1|root,arCOG07813@1|root,arCOG02926@2157|Archaea,arCOG05978@2157|Archaea,arCOG07813@2157|Archaea 2157|Archaea C LamG domain protein jellyroll fold domain protein - - 2.7.11.1 ko:K12567 ko05410,ko05414,map05410,map05414 - - - ko00000,ko00001,ko01000,ko01001,ko04131,ko04147,ko04812 - - - Copper-bind,GSDH,Laminin_G_3,ThuA,fn3 k59_209174_1 1134474.O59_002146 3.09e-75 236.0 COG0042@1|root,COG0042@2|Bacteria,1MUY1@1224|Proteobacteria,1RN28@1236|Gammaproteobacteria,1FH51@10|Cellvibrio 1236|Gammaproteobacteria J Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U20 and U20a in tRNAs dusA GO:0002943,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016491,GO:0016627,GO:0017150,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055114,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 - ko:K05539 - - - - ko00000,ko01000,ko03016 - - - Dus k59_97191_1 297246.lpp0861 8.66e-56 189.0 COG0379@1|root,COG0379@2|Bacteria,1MWQU@1224|Proteobacteria,1RMFS@1236|Gammaproteobacteria,1JCWZ@118969|Legionellales 118969|Legionellales H Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate nadA - 2.5.1.72 ko:K03517 ko00760,ko01100,map00760,map01100 M00115 R04292 RC01119 ko00000,ko00001,ko00002,ko01000 - - - NadA k59_1510790_1 1229909.NSED_00875 4.1e-07 55.1 arCOG10350@1|root,arCOG10350@2157|Archaea 2157|Archaea C sister chromatid segregation - - - - - - - - - - - - - k59_996183_1 1286093.C266_14712 2.1e-53 186.0 COG0433@1|root,COG0433@2|Bacteria,1MUSH@1224|Proteobacteria,2VTF3@28216|Betaproteobacteria,1KHMD@119060|Burkholderiaceae 28216|Betaproteobacteria S Domain of unknown function DUF87 - - - - - - - - - - - - DUF87 k59_829270_1 1168065.DOK_10512 2.53e-26 102.0 COG0824@1|root,COG0824@2|Bacteria,1NN78@1224|Proteobacteria,1SHSA@1236|Gammaproteobacteria,1JABT@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Acyl-ACP thioesterase - - - ko:K07107 - - - - ko00000,ko01000 - - - 4HBT_2 k59_829270_2 436229.JOEH01000011_gene5431 1.01e-11 67.8 COG0657@1|root,COG0657@2|Bacteria,2GKX2@201174|Actinobacteria,2NJ9G@228398|Streptacidiphilus 201174|Actinobacteria I Carboxylesterase family - - - - - - - - - - - - Abhydrolase_3 k59_1568389_1 65071.PYU1_T003191 2.23e-35 131.0 COG0087@1|root,KOG3141@2759|Eukaryota,1MD2J@121069|Pythiales 121069|Pythiales J 50S ribosomal protein L3-2. Source PGD - - - - - - - - - - - - Ribosomal_L3 k59_209184_1 1122599.AUGR01000010_gene1043 1.2e-07 57.0 2E3CB@1|root,32YBM@2|Bacteria,1N6WD@1224|Proteobacteria,1SDBT@1236|Gammaproteobacteria,1XM5F@135619|Oceanospirillales 135619|Oceanospirillales S Domain of unknown function (DUF4154) - - - - - - - - - - - - DUF4154 k59_209184_2 261292.Nit79A3_3197 2.32e-36 142.0 COG1629@1|root,COG4771@2|Bacteria,1MUC1@1224|Proteobacteria,2VH4X@28216|Betaproteobacteria,374R9@32003|Nitrosomonadales 28216|Betaproteobacteria P PFAM TonB-dependent receptor, plug - - - ko:K02014,ko:K16089 - - - - ko00000,ko02000 1.B.14,1.B.14.1,1.B.14.10 - - Plug,TonB_dep_Rec k59_719613_1 1121895.Q765_01970 1.85e-104 315.0 COG1032@1|root,COG1032@2|Bacteria,4NFPW@976|Bacteroidetes,1INE4@117743|Flavobacteriia,2NZ97@237|Flavobacterium 976|Bacteroidetes C Elongator protein 3, MiaB family, Radical SAM - - - - - - - - - - - - B12-binding,DUF4070,Radical_SAM k59_770530_1 1121920.AUAU01000004_gene857 2.12e-120 353.0 COG1804@1|root,COG1804@2|Bacteria,3Y4ZM@57723|Acidobacteria 57723|Acidobacteria C CoA-transferase family III - - - - - - - - - - - - CoA_transf_3 k59_719617_1 199310.c2664 6.2e-112 337.0 COG0277@1|root,COG0277@2|Bacteria,1MVG7@1224|Proteobacteria,1RN5V@1236|Gammaproteobacteria,3XNSW@561|Escherichia 1236|Gammaproteobacteria C Catalyzes the oxidation of D-lactate to pyruvate dld GO:0000166,GO:0003674,GO:0003824,GO:0004457,GO:0004458,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006082,GO:0006089,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009060,GO:0009061,GO:0009898,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016614,GO:0016898,GO:0016901,GO:0019516,GO:0019752,GO:0019897,GO:0019898,GO:0022900,GO:0022904,GO:0031234,GO:0032787,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0045333,GO:0048037,GO:0050660,GO:0050662,GO:0051990,GO:0055114,GO:0071704,GO:0071944,GO:0071949,GO:0097159,GO:0098552,GO:0098562,GO:1901265,GO:1901363,GO:1901615 1.1.5.12 ko:K03777 ko00620,ko01120,map00620,map01120 - R00704,R11591 RC00044 ko00000,ko00001,ko01000 - - iEcHS_1320.EcHS_A2268,iPC815.YPO1177 FAD_binding_4,Lact-deh-memb k59_1675751_1 925775.XVE_4849 7.51e-71 235.0 COG1530@1|root,COG1530@2|Bacteria,1MV65@1224|Proteobacteria,1RMIW@1236|Gammaproteobacteria,1X2ZH@135614|Xanthomonadales 135614|Xanthomonadales J Involved in the processing of the 5'end of 16S rRNA rng - - ko:K08301 - - - - ko00000,ko01000,ko03009,ko03019 - - - RNase_E_G,S1 k59_543189_1 1198452.Jab_2c30780 2.92e-28 110.0 COG0545@1|root,COG0545@2|Bacteria,1RDA1@1224|Proteobacteria,2VSIG@28216|Betaproteobacteria,477PZ@75682|Oxalobacteraceae 28216|Betaproteobacteria O FKBP-type peptidyl-prolyl cis-trans isomerase fkpA - 5.2.1.8 ko:K01802,ko:K03772 - - - - ko00000,ko01000,ko03110 - - - FKBP_C k59_543189_2 478741.JAFS01000001_gene1810 1.24e-19 86.7 COG0225@1|root,COG0229@1|root,COG0225@2|Bacteria,COG0229@2|Bacteria,46TM8@74201|Verrucomicrobia,37G70@326457|unclassified Verrucomicrobia 74201|Verrucomicrobia C Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine msrA - 1.8.4.11,1.8.4.12 ko:K07305,ko:K12267 - - - - ko00000,ko01000 - - - PMSR,SelR k59_1057916_1 1266925.JHVX01000010_gene1317 1.58e-56 196.0 COG1198@1|root,COG1198@2|Bacteria,1MUUZ@1224|Proteobacteria,2VINT@28216|Betaproteobacteria,372GD@32003|Nitrosomonadales 28216|Betaproteobacteria L Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA priA - - ko:K04066 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,Helicase_C,ResIII k59_1057916_2 159087.Daro_3866 1.75e-24 104.0 COG0018@1|root,COG0018@2|Bacteria,1MU4J@1224|Proteobacteria,2VHT1@28216|Betaproteobacteria,2KUXG@206389|Rhodocyclales 206389|Rhodocyclales J Arginyl-tRNA synthetase argS - 6.1.1.19 ko:K01887 ko00970,map00970 M00359,M00360 R03646 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d k59_1510799_1 1347342.BN863_7710 7.35e-113 343.0 COG1452@1|root,COG1452@2|Bacteria,4NDU3@976|Bacteroidetes,1HWTD@117743|Flavobacteriia 976|Bacteroidetes M Organic solvent tolerance protein OstA - - - - - - - - - - - - OstA,OstA_2 k59_719620_1 323848.Nmul_A0442 1.6e-82 256.0 COG3705@1|root,COG3705@2|Bacteria,1MWIG@1224|Proteobacteria,2VHVX@28216|Betaproteobacteria,372G2@32003|Nitrosomonadales 28216|Betaproteobacteria E Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine hisZ - - ko:K02502 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R01071 RC02819,RC03200 ko00000,ko00001,ko00002 - - - tRNA-synt_His k59_719620_2 522306.CAP2UW1_2913 3.62e-20 82.0 COG3242@1|root,COG3242@2|Bacteria,1NG9Q@1224|Proteobacteria,2VXNJ@28216|Betaproteobacteria 28216|Betaproteobacteria S protein conserved in bacteria - - - ko:K09937 - - - - ko00000 - - - DUF2065 k59_719620_3 1454004.AW11_01575 6.52e-25 100.0 COG0330@1|root,COG0330@2|Bacteria,1MV7R@1224|Proteobacteria,2VI9W@28216|Betaproteobacteria,1KQ7P@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria O HflC and HflK could regulate a protease hflC - - ko:K04087 - M00742 - - ko00000,ko00002,ko01000 - - - Band_7 k59_1057932_1 1121374.KB891575_gene797 8.28e-29 114.0 COG1233@1|root,COG1233@2|Bacteria,1MV2R@1224|Proteobacteria,1RSGI@1236|Gammaproteobacteria 1236|Gammaproteobacteria Q COG1233 Phytoene dehydrogenase and related proteins - - - - - - - - - - - - Amino_oxidase,NAD_binding_8 k59_1057932_2 1122135.KB893134_gene3130 2.93e-37 137.0 COG0001@1|root,COG0001@2|Bacteria,1MUY5@1224|Proteobacteria,2TU8Q@28211|Alphaproteobacteria 28211|Alphaproteobacteria H Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family - - 5.4.3.8 ko:K01845 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R02272 RC00677 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3,CTP_transf_3 k59_1110656_1 1121405.dsmv_2629 2.63e-132 393.0 COG0281@1|root,COG0281@2|Bacteria,1MU0A@1224|Proteobacteria,42MDI@68525|delta/epsilon subdivisions,2WIVY@28221|Deltaproteobacteria,2MHYG@213118|Desulfobacterales 28221|Deltaproteobacteria C PFAM malic - - 1.1.1.38,1.1.1.40 ko:K00027,ko:K00029 ko00620,ko00710,ko01100,ko01120,ko01200,ko02020,map00620,map00710,map01100,map01120,map01200,map02020 M00169,M00172 R00214,R00216 RC00105 ko00000,ko00001,ko00002,ko01000 - - - Malic_M,malic k59_889701_1 1165841.SULAR_03857 4.46e-98 291.0 arCOG09454@1|root,30G4A@2|Bacteria,1N61J@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_1785798_1 481448.Minf_1922 3.74e-37 135.0 COG2242@1|root,COG2242@2|Bacteria,46X40@74201|Verrucomicrobia,37H8U@326457|unclassified Verrucomicrobia 74201|Verrucomicrobia H Met-10+ like-protein - - - - - - - - - - - - - k59_1335881_1 1229781.C272_13144 4.7e-11 68.2 COG4974@1|root,COG4974@2|Bacteria,2GNDP@201174|Actinobacteria,4F945@85019|Brevibacteriaceae 201174|Actinobacteria L Phage integrase, N-terminal SAM-like domain xerD GO:0008150,GO:0040007 - ko:K04763 - - - - ko00000,ko03036 - - - Phage_int_SAM_1,Phage_integrase k59_658427_1 1229909.NSED_00265 3.95e-39 132.0 COG1321@1|root,arCOG02100@2157|Archaea,41SIJ@651137|Thaumarchaeota 651137|Thaumarchaeota K Helix-turn-helix diphteria tox regulatory element - - - ko:K03709 - - - - ko00000,ko03000 - - - Fe_dep_repr_C,Fe_dep_repress k59_1449318_2 1444309.JAQG01000090_gene1270 3.33e-86 263.0 COG1089@1|root,COG1089@2|Bacteria,1UJFF@1239|Firmicutes,4HF5Y@91061|Bacilli,275YJ@186822|Paenibacillaceae 91061|Bacilli M Polysaccharide biosynthesis protein - - 1.1.1.281 ko:K15856 ko00051,ko00520,map00051,map00520 - R03397,R03399 RC00182 ko00000,ko00001,ko01000 - - - GDP_Man_Dehyd k59_97242_1 765913.ThidrDRAFT_1634 6.53e-31 117.0 COG0812@1|root,COG0812@2|Bacteria,1MXDH@1224|Proteobacteria,1RNXK@1236|Gammaproteobacteria,1WW8T@135613|Chromatiales 135613|Chromatiales M Cell wall formation murB - 1.3.1.98 ko:K00075 ko00520,ko00550,ko01100,map00520,map00550,map01100 - R03191,R03192 RC02639 ko00000,ko00001,ko01000,ko01011 - - - FAD_binding_4,MurB_C k59_97242_2 913325.N799_03065 1.93e-15 76.6 COG0773@1|root,COG0773@2|Bacteria,1MV68@1224|Proteobacteria,1RN88@1236|Gammaproteobacteria,1X3C1@135614|Xanthomonadales 135614|Xanthomonadales M Belongs to the MurCDEF family murC - 6.3.2.8 ko:K01924 ko00471,ko00550,ko01100,map00471,map00550,map01100 - R03193 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_151637_1 1121097.JCM15093_1419 4.49e-48 174.0 COG1652@1|root,COG4677@1|root,COG1652@2|Bacteria,COG4677@2|Bacteria,4P0WW@976|Bacteroidetes,2FQZK@200643|Bacteroidia,4AMZ3@815|Bacteroidaceae 976|Bacteroidetes G pectinesterase activity - - - - - - - - - - - - - k59_209221_1 324602.Caur_0377 2.22e-33 124.0 COG4221@1|root,COG4221@2|Bacteria,2GA7X@200795|Chloroflexi 200795|Chloroflexi S Belongs to the short-chain dehydrogenases reductases (SDR) family - - - - - - - - - - - - adh_short k59_97246_1 1305836.AXVE01000011_gene1140 3.09e-51 184.0 COG5001@1|root,COG5001@2|Bacteria,1TP8V@1239|Firmicutes,4HA3G@91061|Bacilli,26CYX@186818|Planococcaceae 91061|Bacilli T signal transduction protein containing a membrane domain, an EAL and a GGDEF domain - - - - - - - - - - - - EAL,GAF,GAF_2,GGDEF,PAS,PAS_9 k59_1057962_1 1229909.NSED_05940 3.58e-95 284.0 arCOG12095@1|root,arCOG12095@2157|Archaea 1229909.NSED_05940|- - - - - - - - - - - - - - - - k59_151649_1 62928.azo2523 4.66e-30 109.0 COG3384@1|root,COG3384@2|Bacteria,1RIBC@1224|Proteobacteria,2VSU2@28216|Betaproteobacteria,2KYSN@206389|Rhodocyclales 206389|Rhodocyclales S Aromatic-ring-opening dioxygenase LigAB, LigA subunit - - 1.13.11.8 ko:K04100 ko00362,ko00624,ko00627,ko01120,map00362,map00624,map00627,map01120 - R01632,R03550,R04280,R09565 RC00233,RC00387,RC00535,RC02567,RC02694 br01602,ko00000,ko00001,ko01000 - - - LigA k59_151649_2 1353531.AZNX01000024_gene4674 8.07e-16 76.6 COG2114@1|root,COG2146@1|root,COG2114@2|Bacteria,COG2146@2|Bacteria,1R110@1224|Proteobacteria 1224|Proteobacteria T Adenylyl- / guanylyl cyclase, catalytic domain - - 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 - - - CHASE2,Guanylate_cyc k59_97254_1 1123504.JQKD01000004_gene5106 7.23e-30 119.0 COG0491@1|root,COG0491@2|Bacteria,1MUXF@1224|Proteobacteria,2VKJX@28216|Betaproteobacteria,4AAKM@80864|Comamonadaceae 28216|Betaproteobacteria S PFAM beta-lactamase domain protein - - - - - - - - - - - - Lactamase_B k59_940824_1 402881.Plav_2076 9.57e-15 79.0 COG3746@1|root,COG3746@2|Bacteria,1RA39@1224|Proteobacteria,2U9KD@28211|Alphaproteobacteria 28211|Alphaproteobacteria P PFAM Phosphate-selective porin O and P - - - ko:K07221 - - - - ko00000,ko02000 1.B.5.1 - - Porin_O_P k59_1397940_1 545264.KB898747_gene379 1.81e-28 107.0 COG0781@1|root,COG0781@2|Bacteria,1RHFZ@1224|Proteobacteria,1S6AJ@1236|Gammaproteobacteria,1WY2Q@135613|Chromatiales 135613|Chromatiales K Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons nusB - - ko:K03625 - - - - ko00000,ko03009,ko03021 - - - NusB k59_324754_1 1323361.JPOC01000024_gene1164 3.81e-61 209.0 COG3119@1|root,COG3119@2|Bacteria,2GJ8H@201174|Actinobacteria,4FURR@85025|Nocardiaceae 201174|Actinobacteria P Arylsulfatase - - 3.1.6.1 ko:K01130 ko00140,ko00600,map00140,map00600 - R03980,R04856 RC00128,RC00231 ko00000,ko00001,ko01000 - - - Sulfatase k59_209239_1 391616.OA238_c02430 2.4e-48 167.0 COG3385@1|root,COG3385@2|Bacteria,1R8M9@1224|Proteobacteria,2UI32@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Transposase - - - - - - - - - - - - DDE_Tnp_1 k59_432362_1 715451.ambt_18155 3.66e-25 104.0 COG0598@1|root,COG0598@2|Bacteria,1MW8W@1224|Proteobacteria,1RRTZ@1236|Gammaproteobacteria,464S0@72275|Alteromonadaceae 1236|Gammaproteobacteria P CorA-like Mg2+ transporter protein zntB GO:0000041,GO:0003674,GO:0005215,GO:0005385,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006829,GO:0008150,GO:0008324,GO:0015075,GO:0015318,GO:0015562,GO:0016020,GO:0016021,GO:0022857,GO:0022883,GO:0022890,GO:0030001,GO:0031224,GO:0031226,GO:0034220,GO:0044425,GO:0044459,GO:0044464,GO:0046583,GO:0046873,GO:0046915,GO:0051179,GO:0051234,GO:0055085,GO:0070838,GO:0071577,GO:0071944,GO:0072509,GO:0072511,GO:0098655,GO:0098660,GO:0098662 - ko:K16074 - - - - ko00000,ko02000 1.A.35.4 - - CorA k59_940833_1 595460.RRSWK_04646 5.3e-111 337.0 COG0651@1|root,COG0651@2|Bacteria,2IXRM@203682|Planctomycetes 203682|Planctomycetes CP Proton-conducting membrane transporter - - - ko:K05568 - - - - ko00000,ko02000 2.A.63.1,2.A.63.2 - - Proton_antipo_M k59_996243_1 926569.ANT_15250 2.46e-91 286.0 COG1461@1|root,COG1461@2|Bacteria,2G61Z@200795|Chloroflexi 200795|Chloroflexi S PFAM Dak phosphatase - - - ko:K07030 - - - - ko00000 - - - Dak1_2,Dak2 k59_889723_1 316407.4062324 4.45e-141 403.0 COG1230@1|root,COG1230@2|Bacteria,1MVQB@1224|Proteobacteria,1RMR8@1236|Gammaproteobacteria,3XMQK@561|Escherichia 1236|Gammaproteobacteria P Involved in zinc efflux across the cytoplasmic membrane, thus reducing zinc accumulation in the cytoplasm and rendering bacteria more resistant to zinc. It may contribute to zinc homeostasis at low concentrations of zinc zitB GO:0000041,GO:0003674,GO:0005215,GO:0005385,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006829,GO:0008150,GO:0008324,GO:0015075,GO:0015318,GO:0016020,GO:0022857,GO:0022890,GO:0030001,GO:0034220,GO:0044464,GO:0046873,GO:0046915,GO:0051179,GO:0051234,GO:0055085,GO:0070838,GO:0071577,GO:0071944,GO:0072509,GO:0072511,GO:0098655,GO:0098660,GO:0098662 - ko:K16264 - - - - ko00000,ko02000 2.A.4.1 - iNRG857_1313.NRG857_03325,iPC815.YPO1129 Cation_efflux k59_1568458_1 1300345.LF41_2593 4.53e-22 99.8 COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,1T234@1236|Gammaproteobacteria,1X903@135614|Xanthomonadales 135614|Xanthomonadales S Adenylate cyclase - - - - - - - - - - - - TPR_16 k59_209250_1 335659.S23_10700 2.49e-15 80.5 COG2199@1|root,COG3706@2|Bacteria,1MWHH@1224|Proteobacteria,2TSEP@28211|Alphaproteobacteria,3JVWF@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria T Diguanylate cyclase - - - - - - - - - - - - GGDEF,dCache_1 k59_1733889_2 395495.Lcho_2302 5.3e-16 77.8 COG4949@1|root,COG4949@2|Bacteria,1MVI2@1224|Proteobacteria,2VIAD@28216|Betaproteobacteria,1KJI6@119065|unclassified Burkholderiales 28216|Betaproteobacteria S Protein of unknown function (DUF3422) - - - - - - - - - - - - DUF3422 k59_1785829_1 926569.ANT_10350 4.91e-11 59.7 COG0103@1|root,COG0103@2|Bacteria,2G6UZ@200795|Chloroflexi 200795|Chloroflexi J Belongs to the universal ribosomal protein uS9 family rpsI - - ko:K02996 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S9 k59_1785829_2 1007105.PT7_3532 4.62e-54 174.0 COG0102@1|root,COG0102@2|Bacteria,1RA11@1224|Proteobacteria,2VQ07@28216|Betaproteobacteria,3T3Q0@506|Alcaligenaceae 28216|Betaproteobacteria J This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly rplM - - ko:K02871 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L13 k59_432370_1 236097.ADG881_2625 1.64e-29 121.0 COG3107@1|root,COG3107@2|Bacteria,1MUHR@1224|Proteobacteria,1RXX4@1236|Gammaproteobacteria,1XI39@135619|Oceanospirillales 135619|Oceanospirillales M (Lipo)protein - - - ko:K07121 - - - - ko00000 - - - LppC k59_889730_1 203122.Sde_0832 3.62e-39 148.0 COG0038@1|root,COG0038@2|Bacteria,1MV4K@1224|Proteobacteria,1RQJW@1236|Gammaproteobacteria,465J9@72275|Alteromonadaceae 1236|Gammaproteobacteria P COG0038 Chloride channel protein EriC eriC - - ko:K03281 - - - - ko00000 2.A.49 - - Voltage_CLC k59_1449355_1 491952.Mar181_3169 1.77e-40 145.0 COG2230@1|root,COG2230@2|Bacteria,1MX3U@1224|Proteobacteria,1RNID@1236|Gammaproteobacteria,1XHND@135619|Oceanospirillales 135619|Oceanospirillales M COG2230 Cyclopropane fatty acid synthase and related methyltransferases - - 2.1.1.79 ko:K00574 - - - - ko00000,ko01000 - - - CMAS k59_1449355_2 640512.BC1003_1703 5.44e-13 68.9 COG2303@1|root,COG2303@2|Bacteria,1MV19@1224|Proteobacteria,2VI6F@28216|Betaproteobacteria,1K0X6@119060|Burkholderiaceae 28216|Betaproteobacteria E Belongs to the GMC oxidoreductase family - - 1.1.99.1 ko:K00108 ko00260,ko01100,map00260,map01100 M00555 R01025 RC00087 ko00000,ko00001,ko00002,ko01000 - - - GMC_oxred_C,GMC_oxred_N k59_1449362_1 582744.Msip34_1395 1.84e-75 242.0 COG5316@1|root,COG5316@2|Bacteria,1QCVP@1224|Proteobacteria,2VNEJ@28216|Betaproteobacteria,2KKQV@206350|Nitrosomonadales 206350|Nitrosomonadales S Domain of unknown function (DUF4139) - - - - - - - - - - - - DUF4139 k59_42832_2 879212.DespoDRAFT_00889 6.4e-38 143.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJVV@28221|Deltaproteobacteria,2MI2Z@213118|Desulfobacterales 28221|Deltaproteobacteria V Hydrophobe Amphiphile Efflux-1 (HAE1) Family - - - ko:K03296 - - - - ko00000 2.A.6.2 - - ACR_tran,OEP k59_1399527_2 298655.KI912266_gene992 5.87e-20 96.7 COG4585@1|root,COG4585@2|Bacteria 2|Bacteria T Histidine kinase - - - - - - - - - - - - HATPase_c,HisKA_3,Sensor k59_98688_1 1244869.H261_07071 3.87e-29 122.0 COG3852@1|root,COG5001@1|root,COG3852@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2TQS3@28211|Alphaproteobacteria,2JPBA@204441|Rhodospirillales 204441|Rhodospirillales T Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - - - - - - - - - - EAL,GGDEF,HisKA,PAS,PAS_4,PAS_9,Response_reg k59_433998_1 1088721.NSU_0037 3.62e-17 80.5 COG0358@1|root,COG0358@2|Bacteria,1MUHC@1224|Proteobacteria,2TRU2@28211|Alphaproteobacteria,2K0VR@204457|Sphingomonadales 204457|Sphingomonadales L RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication dnaG - - ko:K02316 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - Toprim_4,Toprim_N,zf-CHC2 k59_433998_2 1088721.NSU_0038 2.99e-47 168.0 COG0568@1|root,COG0568@2|Bacteria,1MVNJ@1224|Proteobacteria,2TS6C@28211|Alphaproteobacteria,2K260@204457|Sphingomonadales 204457|Sphingomonadales K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth rpoD - - ko:K03086 - - - - ko00000,ko03021 - - - Sigma70_ner,Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4 k59_442525_1 316407.85676276 1.83e-137 404.0 COG0129@1|root,COG0129@2|Bacteria,1MUTQ@1224|Proteobacteria,1RMP2@1236|Gammaproteobacteria,3XNTA@561|Escherichia 1236|Gammaproteobacteria E Dihydroxy-acid dehydratase ilvD GO:0003674,GO:0003824,GO:0004160,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006549,GO:0006573,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009097,GO:0009099,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.2.1.9 ko:K01687 ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R01209,R04441,R05070 RC00468,RC01714 ko00000,ko00001,ko00002,ko01000 - - iECIAI39_1322.ECIAI39_3015 ILVD_EDD k59_51219_1 702113.PP1Y_AT35756 3.47e-125 360.0 COG3568@1|root,COG3568@2|Bacteria,1MVN7@1224|Proteobacteria,2U1MH@28211|Alphaproteobacteria,2K0EG@204457|Sphingomonadales 204457|Sphingomonadales L endonuclease - - - - - - - - - - - - Exo_endo_phos k59_1631142_1 1459636.NTE_02474 2.76e-117 355.0 COG0644@1|root,COG2440@1|root,arCOG00570@2157|Archaea,arCOG01984@2157|Archaea,41SXJ@651137|Thaumarchaeota 651137|Thaumarchaeota C Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains - - - ko:K00313 - - - - ko00000,ko01000 - - - - k59_1289717_1 375286.mma_1927 5.99e-21 97.4 COG4774@1|root,COG4774@2|Bacteria,1MV0X@1224|Proteobacteria,2WGH3@28216|Betaproteobacteria,476J0@75682|Oxalobacteraceae 28216|Betaproteobacteria P Hydroxamate-type ferrisiderophore receptor signal peptide protein, tonB-dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_1289717_2 1001585.MDS_4882 1.09e-22 97.1 COG3182@1|root,COG3182@2|Bacteria,1MXGY@1224|Proteobacteria,1RYZN@1236|Gammaproteobacteria,1YD2H@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria S PepSY-associated TM region - - - - - - - - - - - - PepSY_TM k59_1686403_1 926569.ANT_27890 1.54e-27 115.0 COG3845@1|root,COG3845@2|Bacteria,2G625@200795|Chloroflexi 200795|Chloroflexi S PFAM ABC transporter related - - 3.6.3.17 ko:K02056 - M00221 - - ko00000,ko00002,ko01000,ko02000 3.A.1.2 - - ABC_tran k59_553546_1 1122137.AQXF01000003_gene2399 7.31e-24 101.0 COG3746@1|root,COG3746@2|Bacteria,1RA39@1224|Proteobacteria,2U9KD@28211|Alphaproteobacteria 28211|Alphaproteobacteria P PFAM Phosphate-selective porin O and P - - - ko:K07221 - - - - ko00000,ko02000 1.B.5.1 - - Porin_O_P k59_950618_1 266117.Rxyl_2529 4.82e-27 118.0 COG2902@1|root,COG2902@2|Bacteria,2GK0C@201174|Actinobacteria,4CPJ1@84995|Rubrobacteria 84995|Rubrobacteria E Bacterial NAD-glutamate dehydrogenase - - 1.4.1.2 ko:K15371 ko00220,ko00250,ko00430,ko00910,ko01100,map00220,map00250,map00430,map00910,map01100 - R00243 RC00006,RC02799 ko00000,ko00001,ko01000 - - - Bac_GDH k59_899872_1 158500.BV97_01438 1.42e-19 86.3 COG0604@1|root,COG0604@2|Bacteria,1MV3W@1224|Proteobacteria,2TRW7@28211|Alphaproteobacteria,2K3AQ@204457|Sphingomonadales 204457|Sphingomonadales C Zinc-binding dehydrogenase - - - ko:K19745 ko00640,ko01100,map00640,map01100 - R00919 RC00095 ko00000,ko00001,ko01000 - - - ADH_N,ADH_zinc_N k59_899872_2 1123270.ATUR01000006_gene196 1.2e-25 100.0 COG1309@1|root,COG1309@2|Bacteria,1Q53U@1224|Proteobacteria,2UPD9@28211|Alphaproteobacteria,2K556@204457|Sphingomonadales 204457|Sphingomonadales K Bacterial regulatory proteins, tetR family - - - - - - - - - - - - TetR_N k59_1235064_1 502025.Hoch_2431 5.17e-51 171.0 COG0413@1|root,COG0413@2|Bacteria,1MU3B@1224|Proteobacteria,42MES@68525|delta/epsilon subdivisions,2WIQK@28221|Deltaproteobacteria,2YU2N@29|Myxococcales 28221|Deltaproteobacteria H Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate panB - 2.1.2.11 ko:K00606 ko00770,ko01100,ko01110,map00770,map01100,map01110 M00119 R01226 RC00022,RC00200 ko00000,ko00001,ko00002,ko01000 - - - Pantoate_transf k59_391704_1 570967.JMLV01000010_gene1233 5.12e-47 166.0 COG0415@1|root,COG0415@2|Bacteria,1MV9Y@1224|Proteobacteria,2TSDP@28211|Alphaproteobacteria,2JQ32@204441|Rhodospirillales 204441|Rhodospirillales L Belongs to the DNA photolyase family phrB - 4.1.99.3 ko:K01669 - - - - ko00000,ko01000,ko03400 - - - DNA_photolyase,FAD_binding_7 k59_780043_1 1229909.NSED_07555 3.58e-12 65.5 COG1032@1|root,arCOG01357@2157|Archaea,41SCX@651137|Thaumarchaeota 651137|Thaumarchaeota C Radical SAM - - - - - - - - - - - - Radical_SAM k59_780043_2 436308.Nmar_1387 1.25e-33 115.0 COG4919@1|root,arCOG04293@2157|Archaea,41SVI@651137|Thaumarchaeota 651137|Thaumarchaeota J Ribosomal protein S30 - - - ko:K02983 ko03010,map03010 M00177,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011,ko04121 - - - Ribosomal_S30 k59_780043_3 1131266.ARWQ01000004_gene1490 4.38e-11 62.0 COG0468@1|root,arCOG00415@2157|Archaea,41SBA@651137|Thaumarchaeota 651137|Thaumarchaeota L Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules radA - - ko:K04483 - - - - ko00000,ko03400 - - - HHH_5,Rad51 k59_276885_1 582744.Msip34_2147 1.63e-56 181.0 COG2096@1|root,COG2096@2|Bacteria,1RDUF@1224|Proteobacteria,2VQ7P@28216|Betaproteobacteria,2KMKJ@206350|Nitrosomonadales 206350|Nitrosomonadales S PFAM Cobalamin adenosyltransferase - - 2.5.1.17 ko:K00798 ko00860,ko01100,map00860,map01100 M00122 R01492,R05220,R07268 RC00533 ko00000,ko00001,ko00002,ko01000 - - - Cob_adeno_trans k59_276885_2 1033802.SSPSH_001580 4.13e-09 59.3 COG0810@1|root,COG0810@2|Bacteria,1MZXC@1224|Proteobacteria,1S81P@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins tonB - - ko:K03832 - - - - ko00000,ko02000 2.C.1.1 - - TonB_C k59_668850_1 1463825.JNXC01000023_gene4962 7.74e-60 203.0 COG1022@1|root,COG1022@2|Bacteria,2GIXQ@201174|Actinobacteria,4DZ2U@85010|Pseudonocardiales 201174|Actinobacteria I AMP-forming long-chain acyl-CoA synthetase - - 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding k59_1520803_1 1121374.KB891576_gene633 1.1e-101 316.0 COG0457@1|root,COG0457@2|Bacteria,1MVMG@1224|Proteobacteria,1S13F@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Sulfotransferase family - - - - - - - - - - - - Sulfotransfer_3,TPR_16,TPR_19,TPR_8 k59_1179308_1 2340.JV46_14330 6.43e-65 216.0 COG1269@1|root,COG1269@2|Bacteria,1R6B8@1224|Proteobacteria,1RYT3@1236|Gammaproteobacteria 1236|Gammaproteobacteria U Belongs to the V-ATPase 116 kDa subunit family - - - ko:K02123 ko00190,ko01100,map00190,map01100 M00159 - - ko00000,ko00001,ko00002 3.A.2.2,3.A.2.3 - - V_ATPase_I k59_1120363_1 1121439.dsat_2229 1.91e-99 302.0 COG0031@1|root,COG0031@2|Bacteria,1QQKZ@1224|Proteobacteria,42PVJ@68525|delta/epsilon subdivisions,2WKKY@28221|Deltaproteobacteria,2MEAE@213115|Desulfovibrionales 28221|Deltaproteobacteria E PFAM Pyridoxal-5'-phosphate-dependent protein beta subunit - - - - - - - - - - - - PALP k59_729953_1 317655.Sala_1439 2.62e-31 119.0 COG0439@1|root,COG0439@2|Bacteria,1MU4H@1224|Proteobacteria,2U25Z@28211|Alphaproteobacteria,2K11Z@204457|Sphingomonadales 204457|Sphingomonadales I An AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism accC - 6.3.4.14,6.4.1.2 ko:K01961 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04385 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 - - - Biotin_carb_C,Biotin_carb_N,CPSase_L_D2 k59_729953_2 1122137.AQXF01000002_gene354 1.59e-66 206.0 COG0511@1|root,COG0511@2|Bacteria,1RCXA@1224|Proteobacteria,2U93Y@28211|Alphaproteobacteria 28211|Alphaproteobacteria I first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA accB GO:0003674,GO:0003824,GO:0003989,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009305,GO:0009987,GO:0016049,GO:0016053,GO:0016421,GO:0016874,GO:0016885,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0040007,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0072330,GO:1901564,GO:1901576 - ko:K02160 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742 RC00040,RC00367 ko00000,ko00001,ko00002 - - - Biotin_lipoyl k59_729953_3 1122137.AQXF01000002_gene353 4.23e-36 125.0 COG0757@1|root,COG0757@2|Bacteria,1RDDT@1224|Proteobacteria,2U9BV@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Catalyzes a trans-dehydration via an enolate intermediate aroQ - 4.2.1.10 ko:K03786 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R03084 RC00848 ko00000,ko00001,ko00002,ko01000 - - - DHquinase_II k59_729956_1 95619.PM1_0218220 2.71e-81 252.0 COG2255@1|root,COG2255@2|Bacteria,1MU38@1224|Proteobacteria,1RNWY@1236|Gammaproteobacteria 1236|Gammaproteobacteria L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing ruvB GO:0000725,GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0007154,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009314,GO:0009378,GO:0009411,GO:0009416,GO:0009432,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0031668,GO:0032392,GO:0032508,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0051276,GO:0051716,GO:0070035,GO:0071103,GO:0071496,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360 3.6.4.12 ko:K03551 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - RuvB_C,RuvB_N k59_729956_2 745014.OMB55_00018240 2.93e-43 150.0 COG0632@1|root,COG0632@2|Bacteria,1MWJR@1224|Proteobacteria,1RMET@1236|Gammaproteobacteria 1236|Gammaproteobacteria L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB ruvA GO:0000217,GO:0000400,GO:0000725,GO:0003674,GO:0003676,GO:0003677,GO:0003678,GO:0003824,GO:0004386,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0007154,GO:0008150,GO:0008152,GO:0009314,GO:0009378,GO:0009379,GO:0009432,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0022607,GO:0031668,GO:0032392,GO:0032508,GO:0032991,GO:0033202,GO:0033554,GO:0034641,GO:0042802,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0051259,GO:0051260,GO:0051262,GO:0051276,GO:0051289,GO:0051716,GO:0065003,GO:0071103,GO:0071496,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1902494 3.6.4.12 ko:K03550 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - HHH_5,RuvA_C,RuvA_N k59_729956_3 555778.Hneap_0529 1.29e-14 72.8 COG0817@1|root,COG0817@2|Bacteria,1MUJI@1224|Proteobacteria,1RQPJ@1236|Gammaproteobacteria,1WW8M@135613|Chromatiales 135613|Chromatiales L Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group ruvC - 3.1.22.4 ko:K01159 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - RuvC k59_334495_1 1122137.AQXF01000005_gene1293 4.16e-148 429.0 COG0043@1|root,COG0043@2|Bacteria,1MU62@1224|Proteobacteria,2TTSQ@28211|Alphaproteobacteria 28211|Alphaproteobacteria H Belongs to the UbiD family ubiD - 4.1.1.98 ko:K03182 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00117 R04985,R04986 RC00391 ko00000,ko00001,ko00002,ko01000 - - - UbiD k59_553601_1 1547437.LL06_10880 2e-21 97.4 COG0477@1|root,COG2814@2|Bacteria,1MW19@1224|Proteobacteria,2TRJ1@28211|Alphaproteobacteria,43J8Z@69277|Phyllobacteriaceae 28211|Alphaproteobacteria EGP Major Facilitator - - - ko:K07552 - - - - ko00000,ko02000 2.A.1.2 - - MFS_1 k59_1743469_1 768671.ThimaDRAFT_2746 8.92e-31 120.0 COG0422@1|root,COG0422@2|Bacteria,1MUVV@1224|Proteobacteria,1RP1F@1236|Gammaproteobacteria,1WX77@135613|Chromatiales 135613|Chromatiales H Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction thiC - 4.1.99.17 ko:K03147 ko00730,ko01100,map00730,map01100 M00127 R03472 RC03251,RC03252 ko00000,ko00001,ko00002,ko01000 - - - ThiC-associated,ThiC_Rad_SAM k59_1408608_1 1528106.JRJE01000008_gene1557 5.07e-30 118.0 COG4257@1|root,COG4257@2|Bacteria,1QR8W@1224|Proteobacteria,2TRQ1@28211|Alphaproteobacteria,2JU13@204441|Rhodospirillales 204441|Rhodospirillales V Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2-amino-butenoic acid - - - - - - - - - - - - - k59_899926_1 314260.PB2503_08409 1.14e-43 159.0 COG0322@1|root,COG0322@2|Bacteria,1MV38@1224|Proteobacteria,2TT32@28211|Alphaproteobacteria 28211|Alphaproteobacteria L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision uvrC GO:0005575,GO:0005622,GO:0005623,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009380,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0032991,GO:0033554,GO:0044424,GO:0044464,GO:0050896,GO:0051716,GO:0071496,GO:1902494,GO:1905347,GO:1905348,GO:1990391 - ko:K03703 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - GIY-YIG,HHH_2,HHH_5,UVR,UvrC_HhH_N k59_1686453_1 1121897.AUGO01000005_gene102 6.34e-35 134.0 COG3227@1|root,COG3291@1|root,COG3227@2|Bacteria,COG3291@2|Bacteria,4NJHV@976|Bacteroidetes,1IMXD@117743|Flavobacteriia,2NV4Y@237|Flavobacterium 976|Bacteroidetes O Fibronectin type 3 domain - - - - - - - - - - - - fn3 k59_1520830_1 1449076.JOOE01000002_gene734 3.52e-92 299.0 COG1629@1|root,COG4771@2|Bacteria,1R8R0@1224|Proteobacteria,2TTH0@28211|Alphaproteobacteria,2K0E8@204457|Sphingomonadales 204457|Sphingomonadales P TonB dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_899928_1 292414.TM1040_3767 1.22e-42 162.0 COG2911@1|root,COG2931@1|root,COG2982@1|root,COG2911@2|Bacteria,COG2931@2|Bacteria,COG2982@2|Bacteria,1MU7T@1224|Proteobacteria,2TRVY@28211|Alphaproteobacteria,4NCXW@97050|Ruegeria 28211|Alphaproteobacteria Q COG2931 RTX toxins and related Ca2 -binding proteins - - - - - - - - - - - - 5_nucleotid_C,Big_5,Cadherin,DUF4347,HemolysinCabind,Hint_2 k59_839640_1 765914.ThisiDRAFT_2398 3.07e-85 256.0 COG5405@1|root,COG5405@2|Bacteria,1MVF2@1224|Proteobacteria,1RP7P@1236|Gammaproteobacteria,1WVXJ@135613|Chromatiales 135613|Chromatiales O Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery hslV - 3.4.25.2 ko:K01419 - - - - ko00000,ko01000,ko01002 - - - Proteasome k59_334539_1 1415778.JQMM01000001_gene984 2.3e-33 127.0 COG0458@1|root,COG0458@2|Bacteria,1MUDZ@1224|Proteobacteria,1RPIU@1236|Gammaproteobacteria,1J5E8@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria F Carbamoyl-phosphate synthetase ammonia chain carB GO:0000050,GO:0000166,GO:0003674,GO:0003824,GO:0004087,GO:0004088,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005951,GO:0006082,GO:0006139,GO:0006206,GO:0006220,GO:0006221,GO:0006520,GO:0006525,GO:0006526,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016053,GO:0016597,GO:0016874,GO:0016879,GO:0016884,GO:0017076,GO:0018130,GO:0019438,GO:0019627,GO:0019637,GO:0019693,GO:0019752,GO:0019856,GO:0030554,GO:0031406,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046112,GO:0046390,GO:0046394,GO:0046483,GO:0046872,GO:0055086,GO:0071704,GO:0071941,GO:0072527,GO:0072528,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494 6.3.5.5 ko:K01955 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - iAF1260.b0033,iBWG_1329.BWG_0031,iECDH10B_1368.ECDH10B_0034,iECDH1ME8569_1439.ECDH1ME8569_0031,iECUMN_1333.ECUMN_0034,iEcDH1_1363.EcDH1_3566,iJN746.PP_4723,iJO1366.b0033,iJR904.b0033,iPC815.YPO0482,iY75_1357.Y75_RS00170,iYL1228.KPN_00041 CPSase_L_D2,CPSase_L_D3,MGS k59_334539_2 1415778.JQMM01000001_gene985 2.43e-70 215.0 COG0782@1|root,COG0782@2|Bacteria,1RCXW@1224|Proteobacteria,1S3UP@1236|Gammaproteobacteria,1J60X@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria K Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides greA GO:0001098,GO:0001108,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006354,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031326,GO:0032774,GO:0032784,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576,GO:1903506,GO:2000112,GO:2001141 - ko:K03624 - - - - ko00000,ko03021 - - - GreA_GreB,GreA_GreB_N k59_1795815_1 10116.ENSRNOP00000008536 2.08e-13 76.6 COG1404@1|root,KOG1153@2759|Eukaryota,38H6S@33154|Opisthokonta,3BGPH@33208|Metazoa,3CRC0@33213|Bilateria,480EY@7711|Chordata,494VM@7742|Vertebrata,3JG0W@40674|Mammalia,35N36@314146|Euarchontoglires,4PWDC@9989|Rodentia 33208|Metazoa O negative regulation of low-density lipoprotein particle receptor binding PCSK9 GO:0000323,GO:0001655,GO:0001822,GO:0001889,GO:0001919,GO:0001920,GO:0002028,GO:0002090,GO:0002092,GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005102,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005615,GO:0005622,GO:0005623,GO:0005737,GO:0005764,GO:0005765,GO:0005768,GO:0005769,GO:0005770,GO:0005773,GO:0005774,GO:0005783,GO:0005788,GO:0005791,GO:0005794,GO:0005798,GO:0005886,GO:0006066,GO:0006464,GO:0006508,GO:0006629,GO:0006638,GO:0006639,GO:0006641,GO:0006644,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006950,GO:0007034,GO:0007041,GO:0007154,GO:0007275,GO:0007399,GO:0008150,GO:0008152,GO:0008200,GO:0008202,GO:0008203,GO:0008233,GO:0008236,GO:0009056,GO:0009057,GO:0009267,GO:0009605,GO:0009719,GO:0009725,GO:0009892,GO:0009893,GO:0009894,GO:0009896,GO:0009897,GO:0009966,GO:0009968,GO:0009986,GO:0009987,GO:0009991,GO:0010008,GO:0010033,GO:0010243,GO:0010467,GO:0010469,GO:0010604,GO:0010605,GO:0010646,GO:0010648,GO:0010766,GO:0010941,GO:0010942,GO:0010959,GO:0010984,GO:0010985,GO:0010988,GO:0010989,GO:0012505,GO:0016020,GO:0016125,GO:0016247,GO:0016248,GO:0016485,GO:0016540,GO:0016787,GO:0017080,GO:0017171,GO:0019222,GO:0019538,GO:0019637,GO:0019871,GO:0019897,GO:0019898,GO:0022008,GO:0022898,GO:0023051,GO:0023057,GO:0030100,GO:0030134,GO:0030135,GO:0030154,GO:0030163,GO:0030169,GO:0030182,GO:0030545,GO:0030547,GO:0031090,GO:0031232,GO:0031323,GO:0031324,GO:0031325,GO:0031329,GO:0031331,GO:0031410,GO:0031667,GO:0031668,GO:0031669,GO:0031974,GO:0031982,GO:0032091,GO:0032268,GO:0032270,GO:0032368,GO:0032369,GO:0032371,GO:0032372,GO:0032374,GO:0032375,GO:0032377,GO:0032378,GO:0032380,GO:0032381,GO:0032383,GO:0032384,GO:0032386,GO:0032387,GO:0032409,GO:0032410,GO:0032412,GO:0032413,GO:0032501,GO:0032502,GO:0032799,GO:0032801,GO:0032802,GO:0032803,GO:0032805,GO:0032868,GO:0032869,GO:0032870,GO:0032879,GO:0032991,GO:0033554,GO:0034185,GO:0034189,GO:0034190,GO:0034381,GO:0034383,GO:0034762,GO:0034763,GO:0034765,GO:0034766,GO:0036019,GO:0036020,GO:0036211,GO:0042157,GO:0042176,GO:0042221,GO:0042592,GO:0042594,GO:0042632,GO:0042981,GO:0043065,GO:0043067,GO:0043068,GO:0043112,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043269,GO:0043271,GO:0043393,GO:0043412,GO:0043434,GO:0043523,GO:0043525,GO:0043621,GO:0043687,GO:0044092,GO:0044237,GO:0044238,GO:0044248,GO:0044255,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044281,GO:0044421,GO:0044422,GO:0044424,GO:0044425,GO:0044432,GO:0044433,GO:0044437,GO:0044440,GO:0044444,GO:0044446,GO:0044459,GO:0044464,GO:0044877,GO:0045732,GO:0045806,GO:0045807,GO:0046486,GO:0048259,GO:0048260,GO:0048261,GO:0048471,GO:0048513,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048583,GO:0048585,GO:0048699,GO:0048731,GO:0048732,GO:0048856,GO:0048869,GO:0048878,GO:0050750,GO:0050789,GO:0050794,GO:0050896,GO:0051049,GO:0051050,GO:0051051,GO:0051098,GO:0051100,GO:0051128,GO:0051129,GO:0051130,GO:0051171,GO:0051173,GO:0051179,GO:0051234,GO:0051239,GO:0051241,GO:0051246,GO:0051247,GO:0051604,GO:0051716,GO:0055088,GO:0055092,GO:0060255,GO:0060341,GO:0060627,GO:0061008,GO:0065007,GO:0065008,GO:0065009,GO:0070011,GO:0070013,GO:0070325,GO:0070326,GO:0070887,GO:0071310,GO:0071375,GO:0071417,GO:0071495,GO:0071496,GO:0071704,GO:0071813,GO:0071814,GO:0071944,GO:0072001,GO:0080090,GO:0097006,GO:0097708,GO:0098552,GO:0098588,GO:0098772,GO:0098805,GO:0098852,GO:0099106,GO:0140096,GO:1900120,GO:1900121,GO:1901214,GO:1901216,GO:1901360,GO:1901564,GO:1901565,GO:1901575,GO:1901615,GO:1901652,GO:1901653,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902305,GO:1902306,GO:1902652,GO:1903362,GO:1903364,GO:1904062,GO:1904063,GO:1905595,GO:1905596,GO:1905598,GO:1905600,GO:1905601,GO:1905952,GO:1905953,GO:1990666,GO:1990667,GO:2000272,GO:2000644,GO:2000646,GO:2000649,GO:2000650 - ko:K13050 ko04979,map04979 - - - ko00000,ko00001,ko01000,ko01002,ko03110 - - - Inhibitor_I9,Peptidase_S8 k59_218906_1 305700.B447_05458 2.23e-81 259.0 COG1960@1|root,COG1960@2|Bacteria,1MU20@1224|Proteobacteria,2VGZD@28216|Betaproteobacteria,2KUFZ@206389|Rhodocyclales 206389|Rhodocyclales C COG1960 Acyl-CoA dehydrogenases - - - ko:K20035 ko00920,map00920 - R11130 RC03363 ko00000,ko00001,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_C,Acyl-CoA_dh_M,Acyl-CoA_dh_N,AcylCoA_DH_N k59_442602_1 391625.PPSIR1_35857 2.52e-124 367.0 COG0442@1|root,COG0442@2|Bacteria,1MU7E@1224|Proteobacteria,42ME5@68525|delta/epsilon subdivisions,2WJVC@28221|Deltaproteobacteria,2YU5X@29|Myxococcales 28221|Deltaproteobacteria J Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro) proS - 6.1.1.15 ko:K01881 ko00970,map00970 M00359,M00360 R03661 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,ProRS-C_1,tRNA-synt_2b k59_1345960_1 631362.Thi970DRAFT_01076 8.77e-38 139.0 COG2265@1|root,COG2265@2|Bacteria,1MV3A@1224|Proteobacteria,1RN1D@1236|Gammaproteobacteria,1WWDA@135613|Chromatiales 135613|Chromatiales J Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA rlmD - 2.1.1.190 ko:K03215 - - - - ko00000,ko01000,ko03009 - - - TRAM,tRNA_U5-meth_tr k59_553637_1 316407.85676404 3.89e-96 283.0 COG2003@1|root,COG2003@2|Bacteria,1MXZ5@1224|Proteobacteria,1RP86@1236|Gammaproteobacteria,3XMBP@561|Escherichia 1236|Gammaproteobacteria E Belongs to the UPF0758 family. YicR subfamily radC GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360 - ko:K03630 - - - - ko00000 - - - RadC k59_1686485_1 1121949.AQXT01000002_gene645 8.5e-06 47.8 COG0120@1|root,COG0120@2|Bacteria,1MVGR@1224|Proteobacteria,2TU68@28211|Alphaproteobacteria,43WBG@69657|Hyphomonadaceae 28211|Alphaproteobacteria G Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate rpiA - 2.7.1.12,5.3.1.6 ko:K00851,ko:K01807 ko00030,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167,M00580 R01056,R01737 RC00002,RC00017,RC00434 ko00000,ko00001,ko00002,ko01000 - - - Rib_5-P_isom_A k59_1686485_3 765911.Thivi_3390 3.49e-26 105.0 COG0212@1|root,COG0212@2|Bacteria,1MZG0@1224|Proteobacteria,1S612@1236|Gammaproteobacteria,1WYDB@135613|Chromatiales 135613|Chromatiales H Belongs to the 5-formyltetrahydrofolate cyclo-ligase family - - 6.3.3.2 ko:K01934 ko00670,ko01100,map00670,map01100 - R02301 RC00183 ko00000,ko00001,ko01000 - - - 5-FTHF_cyc-lig k59_497906_1 1137799.GZ78_18965 8.17e-36 126.0 COG2001@1|root,COG2001@2|Bacteria,1RHCG@1224|Proteobacteria,1S63F@1236|Gammaproteobacteria,1XJJI@135619|Oceanospirillales 135619|Oceanospirillales K Belongs to the MraZ family mraZ - - ko:K03925 - - - - ko00000 - - - MraZ k59_1795820_1 679935.Alfi_2214 2.48e-19 88.6 COG4227@1|root,COG4227@2|Bacteria,4NRAE@976|Bacteroidetes,2FRYD@200643|Bacteroidia 976|Bacteroidetes L Domain of unknown function (DUF3560) - - - - - - - - - - - - DUF3560 k59_1006357_1 999141.GME_02535 1.36e-47 160.0 COG0039@1|root,COG0039@2|Bacteria,1MV57@1224|Proteobacteria,1RMAX@1236|Gammaproteobacteria,1XIPA@135619|Oceanospirillales 135619|Oceanospirillales C Catalyzes the reversible oxidation of malate to oxaloacetate mdh - 1.1.1.37 ko:K00024 ko00020,ko00270,ko00620,ko00630,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00270,map00620,map00630,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740 R00342,R07136 RC00031 ko00000,ko00001,ko00002,ko01000 - - - Ldh_1_C,Ldh_1_N k59_1006357_2 1238450.VIBNISOn1_1940017 5.05e-17 78.6 COG0494@1|root,COG0494@2|Bacteria,1RDMW@1224|Proteobacteria,1RPZV@1236|Gammaproteobacteria,1XUUC@135623|Vibrionales 135623|Vibrionales L COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes nudF - 3.6.1.13 ko:K01515 ko00230,map00230 - R01054 RC00002 ko00000,ko00001,ko01000 - - - NUDIX k59_780119_1 344747.PM8797T_15426 1.93e-07 60.8 COG0642@1|root,COG5002@1|root,COG0642@2|Bacteria,COG2205@2|Bacteria,COG5002@2|Bacteria,2IXFD@203682|Planctomycetes 203682|Planctomycetes T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - GAF_2,HAMP,HATPase_c,HisKA,Hpt,PAS,PAS_3,PAS_9,Response_reg k59_1520864_1 1056820.KB900641_gene534 4.99e-19 86.3 COG2730@1|root,COG2730@2|Bacteria,1PY25@1224|Proteobacteria,1SYWJ@1236|Gammaproteobacteria,2PMVX@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria G Cellulase (glycosyl hydrolase family 5) - - 3.2.1.4 ko:K01179 ko00500,ko01100,map00500,map01100 - R06200,R11307,R11308 - ko00000,ko00001,ko01000 - GH5,GH9 - CBM_10,CBM_2,CBM_5_12_2,Cellulase,Glyco_hydro_11 k59_899972_1 1122197.ATWI01000012_gene663 7.42e-147 430.0 COG3608@1|root,COG3608@2|Bacteria,1MUAA@1224|Proteobacteria,1RNQQ@1236|Gammaproteobacteria,464NX@72275|Alteromonadaceae 1236|Gammaproteobacteria S Succinylglutamate desuccinylase / Aspartoacylase family - - - ko:K06987 - - - - ko00000 - - - AstE_AspA k59_1006377_2 436308.Nmar_1105 3.14e-113 344.0 COG0556@1|root,arCOG04748@2157|Archaea,41T0H@651137|Thaumarchaeota 651137|Thaumarchaeota L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage uvrB - - ko:K03702 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - Helicase_C,ResIII,UVR,UvrB k59_950694_1 1122137.AQXF01000003_gene2236 4.33e-110 330.0 COG0642@1|root,COG0642@2|Bacteria,1MX6R@1224|Proteobacteria,2TS9N@28211|Alphaproteobacteria 28211|Alphaproteobacteria T Histidine kinase feuQ - - - - - - - - - - - 2CSK_N,HATPase_c k59_901141_2 1125863.JAFN01000001_gene900 6.68e-46 159.0 COG1493@1|root,COG1493@2|Bacteria,1NNN5@1224|Proteobacteria,42P9W@68525|delta/epsilon subdivisions,2WK54@28221|Deltaproteobacteria 28221|Deltaproteobacteria H Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr) hprK GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - ko:K06023 - - - - ko00000,ko01000 - - - Hpr_kinase_C,Hpr_kinase_N k59_499132_1 1280953.HOC_15227 5.21e-29 120.0 COG2272@1|root,COG2272@2|Bacteria,1MVQZ@1224|Proteobacteria,2UPPD@28211|Alphaproteobacteria,43ZBQ@69657|Hyphomonadaceae 28211|Alphaproteobacteria I Belongs to the type-B carboxylesterase lipase family - - - ko:K03929 - - - - ko00000,ko01000 - CE10 - COesterase k59_499134_1 545276.KB898724_gene1958 5.22e-42 145.0 COG0671@1|root,COG0671@2|Bacteria,1RJ1T@1224|Proteobacteria,1SAU1@1236|Gammaproteobacteria,1WXT6@135613|Chromatiales 135613|Chromatiales I PFAM phosphoesterase PA-phosphatase related - - 3.6.1.27 ko:K19302 ko00550,map00550 - R05627 RC00002 ko00000,ko00001,ko01000,ko01011 - - - PAP2 k59_951995_1 1082933.MEA186_25227 2.01e-13 69.7 COG1309@1|root,COG1309@2|Bacteria,1R5AI@1224|Proteobacteria,2U5HX@28211|Alphaproteobacteria,43R08@69277|Phyllobacteriaceae 28211|Alphaproteobacteria K Bacterial regulatory proteins, tetR family - - - - - - - - - - - - TetR_N k59_951995_2 1122917.KB899663_gene2772 2.19e-15 74.7 2DCFK@1|root,2ZDY1@2|Bacteria,1W5KF@1239|Firmicutes,4HZTU@91061|Bacilli,26ZEH@186822|Paenibacillaceae 91061|Bacilli - - - - - - - - - - - - - - - k59_951998_1 1121035.AUCH01000008_gene1067 8.1e-53 171.0 COG2885@1|root,COG2885@2|Bacteria,1MZTV@1224|Proteobacteria,2VSP6@28216|Betaproteobacteria,2KWKV@206389|Rhodocyclales 206389|Rhodocyclales M Belongs to the ompA family - - - ko:K03640 - - - - ko00000,ko02000 2.C.1.2 - - OmpA k59_951998_2 398527.Bphyt_0757 6.96e-19 88.2 COG1729@1|root,COG1729@2|Bacteria,1MUSV@1224|Proteobacteria,2VIPC@28216|Betaproteobacteria,1K2X7@119060|Burkholderiaceae 28216|Betaproteobacteria D Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division cpoB - - - - - - - - - - - TPR_16,TPR_6,TolA_bind_tri,YfiO k59_1347239_1 1121957.ATVL01000006_gene3280 3.51e-10 62.0 COG1845@1|root,COG1845@2|Bacteria,4NFA7@976|Bacteroidetes,47NS2@768503|Cytophagia 976|Bacteroidetes C PFAM cytochrome c oxidase subunit III ctaE - 1.9.3.1 ko:K02276 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.4,3.D.4.6 - - COX3 k59_1687709_1 234267.Acid_6465 4.34e-67 228.0 COG1629@1|root,COG4771@2|Bacteria,3Y33S@57723|Acidobacteria 57723|Acidobacteria P Carboxypeptidase regulatory-like domain - - - - - - - - - - - - CarboxypepD_reg,Plug k59_781444_1 511062.GU3_01305 1.4e-116 345.0 COG0240@1|root,COG0240@2|Bacteria,1MUU3@1224|Proteobacteria,1RPQ7@1236|Gammaproteobacteria,1Y3T2@135624|Aeromonadales 135624|Aeromonadales I Glycerol-3-phosphate dehydrogenase gpsA - 1.1.1.94 ko:K00057 ko00564,ko01110,map00564,map01110 - R00842,R00844 RC00029 ko00000,ko00001,ko01000 - - - NAD_Gly3P_dh_C,NAD_Gly3P_dh_N k59_1347248_1 1122201.AUAZ01000002_gene993 2.68e-29 120.0 COG1530@1|root,COG1530@2|Bacteria,1MV65@1224|Proteobacteria,1RMDS@1236|Gammaproteobacteria,464FV@72275|Alteromonadaceae 1236|Gammaproteobacteria J Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs rne - 3.1.26.12 ko:K08300 ko03018,map03018 M00394 - - ko00000,ko00001,ko00002,ko01000,ko03009,ko03019 - - - RNase_E_G,S1 k59_731230_1 1458357.BG58_24125 5.44e-69 219.0 COG0232@1|root,COG0232@2|Bacteria,1MVQ2@1224|Proteobacteria,2VI7B@28216|Betaproteobacteria,1K15K@119060|Burkholderiaceae 28216|Betaproteobacteria F Belongs to the dGTPase family. Type 2 subfamily dgt - 3.1.5.1 ko:K01129 ko00230,map00230 - R01856 RC00017 ko00000,ko00001,ko01000 - - - HD,HD_assoc k59_731230_2 748280.NH8B_3692 2.5e-43 152.0 COG0337@1|root,COG0337@2|Bacteria,1MUBK@1224|Proteobacteria,2VHXR@28216|Betaproteobacteria,2KQ69@206351|Neisseriales 206351|Neisseriales E Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) aroB - 4.2.3.4 ko:K01735 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R03083 RC00847 ko00000,ko00001,ko00002,ko01000 - - - DHQ_synthase k59_1632499_1 290400.Jann_2941 3.5e-59 199.0 COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,2TRM1@28211|Alphaproteobacteria 28211|Alphaproteobacteria G COG1593 TRAP-type C4-dicarboxylate transport system, large permease component - - - - - - - - - - - - DctM k59_781449_1 323261.Noc_1383 1.05e-07 50.8 COG0789@1|root,COG0789@2|Bacteria,1N9MT@1224|Proteobacteria,1SE7J@1236|Gammaproteobacteria,1WZDM@135613|Chromatiales 135613|Chromatiales K MerR HTH family regulatory protein - - - ko:K18997 - - - - ko00000,ko03036 - - - MerR_2 k59_781449_2 1265313.HRUBRA_02790 3.22e-14 75.1 COG0668@1|root,COG0668@2|Bacteria,1N66N@1224|Proteobacteria,1RQWI@1236|Gammaproteobacteria,1J5R8@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Mechanosensitive ion channel - - - - - - - - - - - - MS_channel k59_1291171_1 1123392.AQWL01000005_gene3134 6.7e-55 186.0 COG0696@1|root,COG0696@2|Bacteria,1MUQ1@1224|Proteobacteria,2VMTN@28216|Betaproteobacteria,1KS9H@119069|Hydrogenophilales 119069|Hydrogenophilales F Metalloenzyme superfamily - - 5.4.2.12 ko:K15633 ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003 R01518 RC00536 ko00000,ko00001,ko00002,ko01000 - - - Metalloenzyme,Phosphodiest,iPGM_N k59_1687722_1 298654.FraEuI1c_1474 9.97e-59 196.0 COG1012@1|root,COG1012@2|Bacteria 2|Bacteria C belongs to the aldehyde dehydrogenase family luxC - 1.2.1.50 ko:K03400 ko02020,ko02024,map02020,map02024 - R10549 RC00004,RC00184 ko00000,ko00001,ko01000 - - - LuxC k59_1347253_1 314282.PCNPT3_07895 1.44e-79 255.0 COG4146@1|root,COG4146@2|Bacteria,1MXWV@1224|Proteobacteria,1RR4S@1236|Gammaproteobacteria 1236|Gammaproteobacteria E Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family sglT - - ko:K03307 - - - - ko00000 2.A.21 - - SSF k59_1347254_1 1122604.JONR01000025_gene4532 2.23e-44 165.0 COG0587@1|root,COG0587@2|Bacteria,1MUE4@1224|Proteobacteria,1RQA8@1236|Gammaproteobacteria,1X3V7@135614|Xanthomonadales 135614|Xanthomonadales L DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase dnaE2 - 2.7.7.7 ko:K14162 - - - - ko00000,ko01000,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon k59_452736_1 420324.KI911947_gene5678 9.81e-68 209.0 COG0678@1|root,COG0678@2|Bacteria,1MU0H@1224|Proteobacteria,2TU5A@28211|Alphaproteobacteria 28211|Alphaproteobacteria O Peroxiredoxin - - - - - - - - - - - - Redoxin k59_1526301_1 1122137.AQXF01000002_gene419 2.59e-77 232.0 COG0346@1|root,COG0346@2|Bacteria,1N08M@1224|Proteobacteria,2UCUW@28211|Alphaproteobacteria 28211|Alphaproteobacteria E COG0346 Lactoylglutathione lyase and related lyases - - - - - - - - - - - - Glyoxalase k59_1526301_2 1182590.BN5_02426 1.43e-89 275.0 COG3386@1|root,COG3386@2|Bacteria,1MX7V@1224|Proteobacteria,1RMQK@1236|Gammaproteobacteria,1YF6H@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria G Strictosidine synthase - - - - - - - - - - - - Str_synth k59_1018089_1 357804.Ping_0228 5.71e-18 87.0 COG0002@1|root,COG0002@2|Bacteria,1MVJ6@1224|Proteobacteria,1RNMX@1236|Gammaproteobacteria,2QIWG@267894|Psychromonadaceae 1236|Gammaproteobacteria E Semialdehyde dehydrogenase, NAD binding domain argC GO:0003674,GO:0003824,GO:0003942,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016491,GO:0016620,GO:0016903,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.2.1.38 ko:K00145 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028,M00845 R03443 RC00684 ko00000,ko00001,ko00002,ko01000 - - iSSON_1240.SSON_4131 Semialdhyde_dh,Semialdhyde_dhC k59_904777_1 1205908.AKXW01000045_gene3643 2.44e-67 219.0 COG1680@1|root,COG1680@2|Bacteria,1P3SQ@1224|Proteobacteria,1SWQV@1236|Gammaproteobacteria,1XSBM@135623|Vibrionales 135623|Vibrionales V Beta-lactamase - - - - - - - - - - - - Beta-lactamase k59_961261_1 316407.85676505 5.91e-70 221.0 COG0814@1|root,COG0814@2|Bacteria,1PCGR@1224|Proteobacteria,1RSH4@1236|Gammaproteobacteria,3XN9W@561|Escherichia 1236|Gammaproteobacteria E amino acid transmembrane transport yhjV GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0009314,GO:0009628,GO:0016020,GO:0044464,GO:0050896,GO:0071944 - - - - - - - - - - Trp_Tyr_perm k59_904778_1 1158756.AQXQ01000011_gene893 5.69e-57 193.0 COG0144@1|root,COG0144@2|Bacteria,1MWPE@1224|Proteobacteria,1RN8X@1236|Gammaproteobacteria,1WVWG@135613|Chromatiales 135613|Chromatiales J Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA - - 2.1.1.176 ko:K03500 - - - - ko00000,ko01000,ko03009 - - - Methyltr_RsmB-F,Methyltr_RsmF_N,NusB k59_57517_1 404589.Anae109_4390 6.72e-146 430.0 COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,42M4Z@68525|delta/epsilon subdivisions,2WJZ3@28221|Deltaproteobacteria 28221|Deltaproteobacteria O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins - - - ko:K03798 - M00742 - - ko00000,ko00002,ko01000,ko01002,ko03110 - - - AAA,FtsH_ext,Peptidase_M41 k59_566006_1 160492.XF_0049 1.74e-34 130.0 COG0439@1|root,COG0439@2|Bacteria,1MU4H@1224|Proteobacteria,1RMNB@1236|Gammaproteobacteria,1X43Q@135614|Xanthomonadales 135614|Xanthomonadales I An AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism accC - 6.3.4.14,6.4.1.2 ko:K01961 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04385 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 - - - Biotin_carb_C,Biotin_carb_N,CPSase_L_D2 k59_566006_2 765914.ThisiDRAFT_0562 2.61e-10 63.2 COG2264@1|root,COG2264@2|Bacteria,1MUPC@1224|Proteobacteria,1RNAR@1236|Gammaproteobacteria,1WX2W@135613|Chromatiales 135613|Chromatiales J Ribosomal protein L11 methyltransferase prmA - - ko:K02687 - - - - ko00000,ko01000,ko03009 - - - PrmA k59_622324_1 397278.JOJN01000007_gene3295 6.18e-153 441.0 COG1960@1|root,COG1960@2|Bacteria,2GMEM@201174|Actinobacteria,4DNK5@85009|Propionibacteriales 201174|Actinobacteria I Acyl-CoA dehydrogenase, C-terminal domain fadE19 GO:0000062,GO:0000166,GO:0003674,GO:0003824,GO:0003995,GO:0004085,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005759,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0006950,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009605,GO:0009719,GO:0009725,GO:0009987,GO:0009991,GO:0010033,GO:0014070,GO:0016020,GO:0016042,GO:0016043,GO:0016054,GO:0016491,GO:0016627,GO:0017076,GO:0019395,GO:0019605,GO:0019626,GO:0019752,GO:0022607,GO:0030258,GO:0030554,GO:0031090,GO:0031667,GO:0031960,GO:0031966,GO:0031967,GO:0031974,GO:0031975,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0033218,GO:0033539,GO:0033993,GO:0034440,GO:0036094,GO:0042221,GO:0042594,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046359,GO:0046395,GO:0046459,GO:0048037,GO:0048545,GO:0050660,GO:0050662,GO:0050896,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0051384,GO:0052890,GO:0055114,GO:0065003,GO:0070013,GO:0071704,GO:0071840,GO:0072329,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901567,GO:1901575,GO:1901681 1.3.8.1,1.3.99.12 ko:K00248,ko:K11410 ko00071,ko00280,ko00650,ko01100,ko01110,ko01120,ko01200,ko01212,map00071,map00280,map00650,map01100,map01110,map01120,map01200,map01212 - R01175,R01178,R02661,R03172,R04751 RC00052,RC00068,RC00076,RC00120,RC00148 ko00000,ko00001,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_340036_2 1150469.RSPPHO_02499 2.54e-09 57.4 COG2350@1|root,COG2350@2|Bacteria,1MZ9Z@1224|Proteobacteria,2UF4X@28211|Alphaproteobacteria,2JTUA@204441|Rhodospirillales 204441|Rhodospirillales S Protein conserved in bacteria - - - ko:K09780 - - - - ko00000 - - - YCII k59_622329_1 1195246.AGRI_01425 1.41e-53 186.0 COG0845@1|root,COG0845@2|Bacteria,1PEVY@1224|Proteobacteria,1RPEQ@1236|Gammaproteobacteria,465PN@72275|Alteromonadaceae 1236|Gammaproteobacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - - - - - - - - - - Biotin_lipoyl_2,HlyD_3 k59_1130959_1 1122137.AQXF01000001_gene2984 1.32e-123 365.0 COG0733@1|root,COG0733@2|Bacteria,1MUZJ@1224|Proteobacteria,2TUE5@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Belongs to the sodium neurotransmitter symporter (SNF) (TC 2.A.22) family - - - ko:K03308 - - - - ko00000 2.A.22.4,2.A.22.5 - - SNF k59_452779_1 1117318.PRUB_19654 4.02e-07 53.1 COG0585@1|root,COG0585@2|Bacteria,1MXHD@1224|Proteobacteria,1RPRF@1236|Gammaproteobacteria,2Q0VY@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria J Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs truD GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0016070,GO:0016853,GO:0016866,GO:0034641,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360 5.4.99.27 ko:K06176 - - - - ko00000,ko01000,ko03016 - - - TruD k59_452779_2 1123367.C666_11905 2.84e-34 125.0 COG0518@1|root,COG0518@2|Bacteria,1MUDH@1224|Proteobacteria,2VJEI@28216|Betaproteobacteria,2KWJH@206389|Rhodocyclales 206389|Rhodocyclales F Glutamine amidotransferase class-I - - - - - - - - - - - - GATase k59_1582841_1 1121352.JHZP01000001_gene416 9.89e-12 68.6 COG3914@1|root,COG3914@2|Bacteria,1PEV2@1224|Proteobacteria,2VNE2@28216|Betaproteobacteria,2KQU4@206351|Neisseriales 206351|Neisseriales O O-linked N-acetylglucosamine transferase SPINDLY family - - - - - - - - - - - - - k59_622338_1 555793.WSK_0964 2.16e-171 494.0 COG0129@1|root,COG0129@2|Bacteria,1MUTQ@1224|Proteobacteria,2TRTQ@28211|Alphaproteobacteria,2K026@204457|Sphingomonadales 204457|Sphingomonadales EG Belongs to the IlvD Edd family ilvD - 4.2.1.9 ko:K01687 ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R01209,R04441,R05070 RC00468,RC01714 ko00000,ko00001,ko00002,ko01000 - - - ILVD_EDD k59_1695726_1 497964.CfE428DRAFT_6337 7.78e-46 158.0 COG1702@1|root,COG1702@2|Bacteria,46S7S@74201|Verrucomicrobia 74201|Verrucomicrobia T PhoH-like protein - - - ko:K06217 - - - - ko00000 - - - PhoH k59_283630_1 290397.Adeh_4332 1.35e-55 196.0 COG1197@1|root,COG1197@2|Bacteria,1MUXG@1224|Proteobacteria,42N8X@68525|delta/epsilon subdivisions,2WIVR@28221|Deltaproteobacteria,2YUID@29|Myxococcales 28221|Deltaproteobacteria L Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site mfd - - ko:K03723 ko03420,map03420 - - - ko00000,ko00001,ko01000,ko03400 - - - CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF k59_509395_1 391625.PPSIR1_27003 1.73e-43 162.0 COG2203@1|root,COG3899@1|root,COG4191@1|root,COG2203@2|Bacteria,COG3899@2|Bacteria,COG4191@2|Bacteria,1R609@1224|Proteobacteria,42MTJ@68525|delta/epsilon subdivisions,2WJYM@28221|Deltaproteobacteria,2Z2WR@29|Myxococcales 28221|Deltaproteobacteria T COG0515 Serine threonine protein kinase - - - - - - - - - - - - AAA_16,GAF,GAF_2,HATPase_c,HisKA,PAS_3,PAS_4,PAS_9,Pkinase k59_1469938_1 313595.P700755_000211 8.33e-94 283.0 28KCT@1|root,2Z9ZM@2|Bacteria,4NG7C@976|Bacteroidetes,1I08I@117743|Flavobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_1469938_2 313595.P700755_000210 8.06e-80 239.0 2BGNM@1|root,32AMA@2|Bacteria,4NUKD@976|Bacteroidetes,1I4IU@117743|Flavobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_1243836_1 1366050.N234_30170 1.15e-18 85.9 COG1894@1|root,COG1905@1|root,COG1894@2|Bacteria,COG1905@2|Bacteria,1MV8F@1224|Proteobacteria,2VIMM@28216|Betaproteobacteria,1K5P1@119060|Burkholderiaceae 28216|Betaproteobacteria C formate dehydrogenase fdwB - 1.17.1.9 ko:K00122 ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200 - R00519 RC02796 ko00000,ko00001,ko01000 - - - 2Fe-2S_thioredx,Complex1_51K,NADH_4Fe-4S,SLBB k59_622348_1 1297742.A176_02083 5.56e-47 166.0 COG1473@1|root,COG1473@2|Bacteria,1MUIV@1224|Proteobacteria,42NR8@68525|delta/epsilon subdivisions,2WM9T@28221|Deltaproteobacteria,2Z05D@29|Myxococcales 28221|Deltaproteobacteria M Peptidase dimerisation domain - - - ko:K01436 - - - - ko00000,ko01000,ko01002 - - - M20_dimer,Peptidase_M20 k59_1243844_1 690850.Desaf_1445 1.76e-09 63.9 COG5002@1|root,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,42NK9@68525|delta/epsilon subdivisions,2WMCQ@28221|Deltaproteobacteria,2MH9G@213115|Desulfovibrionales 28221|Deltaproteobacteria T response regulator, receiver - - - - - - - - - - - - HATPase_c,HisKA,Hpt,PAS,PAS_3,PAS_4,PAS_9,Response_reg k59_1130978_1 751945.Theos_0562 1.69e-08 63.5 COG0312@1|root,COG0312@2|Bacteria,1WIK5@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus S modulator of DNA gyrase tldD - - ko:K03568 - - - - ko00000,ko01002 - - - PmbA_TldD k59_1130983_1 861299.J421_0339 2.2e-14 72.8 COG2303@1|root,COG2303@2|Bacteria 2|Bacteria E choline dehydrogenase activity - - - - - - - - - - - - GMC_oxred_C,GMC_oxred_N k59_341082_3 994479.GL877884_gene7723 1.37e-37 132.0 COG0350@1|root,COG0350@2|Bacteria,2IHXW@201174|Actinobacteria,4E3JX@85010|Pseudonocardiales 201174|Actinobacteria L Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated ogt GO:0003674,GO:0003824,GO:0003908,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006304,GO:0006307,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0009987,GO:0016020,GO:0016740,GO:0016741,GO:0032259,GO:0033554,GO:0034641,GO:0035510,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0050896,GO:0051409,GO:0051716,GO:0071704,GO:0071944,GO:0090304,GO:1901360 2.1.1.63 ko:K00567 - - - - ko00000,ko01000,ko03400 - - - DNA_binding_1,Methyltransf_1N k59_284642_1 1096930.L284_07475 9.23e-123 363.0 COG0516@1|root,COG0517@1|root,COG0516@2|Bacteria,COG0517@2|Bacteria,1MUJM@1224|Proteobacteria,2TQXC@28211|Alphaproteobacteria,2K0CG@204457|Sphingomonadales 204457|Sphingomonadales F Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth guaB - 1.1.1.205 ko:K00088 ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 M00050 R01130,R08240 RC00143,RC02207 ko00000,ko00001,ko00002,ko01000,ko04147 - - - CBS,IMPDH,NMO k59_1583673_1 265072.Mfla_1778 9.4e-32 120.0 COG3111@1|root,COG3111@2|Bacteria,1MU8B@1224|Proteobacteria,2VSNU@28216|Betaproteobacteria,2KMH8@206350|Nitrosomonadales 206350|Nitrosomonadales S short chain amide porin - - - - - - - - - - - - - k59_1188331_1 13690.CP98_03897 6.97e-87 266.0 COG1960@1|root,COG1960@2|Bacteria,1MVAH@1224|Proteobacteria,2TR02@28211|Alphaproteobacteria,2K124@204457|Sphingomonadales 204457|Sphingomonadales I acyl-CoA dehydrogenase - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_1640311_1 448385.sce0202 4.79e-48 176.0 COG1858@1|root,COG3391@1|root,COG1858@2|Bacteria,COG3391@2|Bacteria,1R66T@1224|Proteobacteria 1224|Proteobacteria C amine dehydrogenase activity - - - - - - - - - - - - - k59_736563_1 436308.Nmar_0926 2.76e-136 403.0 COG0441@1|root,arCOG00401@2157|Archaea,41S9K@651137|Thaumarchaeota 651137|Thaumarchaeota J Belongs to the class-II aminoacyl-tRNA synthetase family thrS - 6.1.1.3 ko:K01868 ko00970,map00970 M00359,M00360 R03663 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,tRNA-Thr_ED,tRNA-synt_2b k59_171684_1 1217718.ALOU01000093_gene1735 2.5e-83 262.0 COG2303@1|root,COG2303@2|Bacteria,1MV19@1224|Proteobacteria,2VI6F@28216|Betaproteobacteria,1K2NR@119060|Burkholderiaceae 28216|Betaproteobacteria E (GMC) oxidoreductase betA - 1.1.99.1 ko:K00108 ko00260,ko01100,map00260,map01100 M00555 R01025 RC00087 ko00000,ko00001,ko00002,ko01000 - - - GMC_oxred_C,GMC_oxred_N k59_1527323_1 1167006.UWK_01273 4.34e-41 155.0 COG0840@1|root,COG4191@1|root,COG0840@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42PDY@68525|delta/epsilon subdivisions,2WMD0@28221|Deltaproteobacteria,2MPRX@213118|Desulfobacterales 28221|Deltaproteobacteria T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - GAF_2,HATPase_c,HisKA,PAS,PAS_4,PAS_9,Response_reg k59_962389_1 314345.SPV1_00967 4.5e-66 225.0 COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria 1224|Proteobacteria P ATPase, P-type transporting, HAD superfamily, subfamily IC - - 3.6.3.8,3.6.3.9 ko:K01537,ko:K01539 ko04022,ko04024,ko04260,ko04261,ko04911,ko04918,ko04919,ko04925,ko04960,ko04961,ko04964,ko04970,ko04971,ko04972,ko04973,ko04974,ko04976,ko04978,map04022,map04024,map04260,map04261,map04911,map04918,map04919,map04925,map04960,map04961,map04964,map04970,map04971,map04972,map04973,map04974,map04976,map04978 - - - ko00000,ko00001,ko01000,ko04147 3.A.3.1,3.A.3.2 - - Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3,PTS_EIIA_2 k59_736569_1 391625.PPSIR1_08821 3.31e-44 165.0 COG3829@1|root,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria,43BKG@68525|delta/epsilon subdivisions,2X6YI@28221|Deltaproteobacteria,2YTVN@29|Myxococcales 28221|Deltaproteobacteria K Bacterial regulatory protein, Fis family - - - ko:K02584 ko02020,map02020 - - - ko00000,ko00001,ko03000 - - - GAF,GAF_2,HTH_8,Pkinase,PocR,Sigma54_activat k59_1301519_1 983544.Lacal_1630 8.23e-104 319.0 COG0022@1|root,COG1071@1|root,COG0022@2|Bacteria,COG1071@2|Bacteria,4NE71@976|Bacteroidetes,1HXMC@117743|Flavobacteriia 976|Bacteroidetes C Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type bfmBAB - 1.2.4.4 ko:K11381 ko00280,ko00640,ko01100,ko01110,ko01130,map00280,map00640,map01100,map01110,map01130 M00036 R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997 RC00027,RC00627,RC02743,RC02883,RC02949,RC02953 br01601,ko00000,ko00001,ko00002,ko01000 - - - E1_dh,Transket_pyr,Transketolase_C k59_1188350_1 1123236.KB899376_gene756 1.08e-96 306.0 COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,1N4G0@1224|Proteobacteria,1RRIM@1236|Gammaproteobacteria,464YA@72275|Alteromonadaceae 1236|Gammaproteobacteria EU COG1506 Dipeptidyl aminopeptidases acylaminoacyl-peptidases - - - - - - - - - - - - DPPIV_N,PD40,Peptidase_S9 k59_1301528_1 1353276.JADR01000001_gene710 1.32e-80 252.0 COG2067@1|root,COG2067@2|Bacteria,4NG1B@976|Bacteroidetes,1HY7J@117743|Flavobacteriia 976|Bacteroidetes I Protein of unknown function (DUF3570) - - - - - - - - - - - - DUF3570 k59_1527336_1 1280952.HJA_00045 2.42e-09 64.7 COG0457@1|root,COG3710@1|root,COG5616@1|root,COG0457@2|Bacteria,COG3710@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2TRUI@28211|Alphaproteobacteria,43XNB@69657|Hyphomonadaceae 28211|Alphaproteobacteria T Adenylate cyclase - - - - - - - - - - - - TIR_2,TPR_16,TPR_8,Trans_reg_C k59_397528_1 1201293.AKXQ01000003_gene2560 2.06e-40 150.0 COG1228@1|root,COG1228@2|Bacteria,1MVAF@1224|Proteobacteria,1RQRP@1236|Gammaproteobacteria 1236|Gammaproteobacteria Q COG1228 Imidazolonepropionase and related amidohydrolases - - - - - - - - - - - - Amidohydro_1 k59_793033_1 1415778.JQMM01000001_gene1239 2.13e-142 418.0 COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,1RMQQ@1236|Gammaproteobacteria,1J523@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H COG0028 Thiamine pyrophosphate-requiring enzymes acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase ilvI GO:0000287,GO:0003674,GO:0003824,GO:0003984,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006549,GO:0006573,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009097,GO:0009099,GO:0009987,GO:0016053,GO:0016740,GO:0016744,GO:0019752,GO:0019842,GO:0030976,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046872,GO:0048037,GO:0050662,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1901681 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - iAPECO1_1312.APECO1_1907,iB21_1397.B21_00078,iBWG_1329.BWG_0073,iECBD_1354.ECBD_3539,iECB_1328.ECB_00079,iECD_1391.ECD_00079,iUTI89_1310.UTI89_C0085,iYL1228.KPN_00082 TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_341132_1 511145.b1449 1.56e-127 369.0 COG2130@1|root,COG2130@2|Bacteria,1MUC2@1224|Proteobacteria,1RNGM@1236|Gammaproteobacteria,3XNV4@561|Escherichia 1236|Gammaproteobacteria S Catalyzes the metal-independent reduction of curcumin to dihydrocurcumin (DHC) as an intermediate product, followed by further reduction to tetrahydrocurcumin (THC) as an end product. It also acts on 3-octene-2-one, 3-hepten-2-one, resveratrol, and trans-2-octenal yncB - - ko:K07119 - - - - ko00000 - - - ADH_N_2,ADH_zinc_N k59_341132_2 198214.SF1765 1.69e-21 89.4 COG1802@1|root,COG1802@2|Bacteria,1MVXM@1224|Proteobacteria,1S2YM@1236|Gammaproteobacteria 1236|Gammaproteobacteria K transcriptional regulator mcbR GO:0003674,GO:0003700,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0140110,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 - ko:K13654 - - - - ko00000,ko03000 - - - FCD,GntR k59_1527337_1 1122137.AQXF01000003_gene2071 3.83e-259 725.0 COG0358@1|root,COG0358@2|Bacteria,1MUHC@1224|Proteobacteria,2TRU2@28211|Alphaproteobacteria 28211|Alphaproteobacteria L RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication dnaG - - ko:K02316 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB_bind,Toprim_2,Toprim_4,Toprim_N,zf-CHC2 k59_1188363_1 1122137.AQXF01000001_gene3186 4.78e-108 336.0 COG2844@1|root,COG2844@2|Bacteria,1MV54@1224|Proteobacteria,2TSV0@28211|Alphaproteobacteria 28211|Alphaproteobacteria O Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen glnD GO:0006355,GO:0006464,GO:0006807,GO:0006808,GO:0007154,GO:0007584,GO:0008150,GO:0008152,GO:0009605,GO:0009719,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0009991,GO:0010033,GO:0010243,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0018175,GO:0018177,GO:0019219,GO:0019222,GO:0019538,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031667,GO:0031668,GO:0031669,GO:0031670,GO:0036211,GO:0042221,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051716,GO:0060255,GO:0065007,GO:0070887,GO:0071310,GO:0071417,GO:0071495,GO:0071496,GO:0071704,GO:0080090,GO:0090293,GO:1901564,GO:1901698,GO:1901699,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141 2.7.7.59 ko:K00990 ko02020,map02020 - - - ko00000,ko00001,ko01000 - - - ACT,GlnD_UR_UTase,GlnE,HD,NTP_transf_2 k59_510354_1 1096930.L284_01670 1.75e-121 350.0 COG0020@1|root,COG0020@2|Bacteria,1MVP1@1224|Proteobacteria,2TTVJ@28211|Alphaproteobacteria,2K0JM@204457|Sphingomonadales 204457|Sphingomonadales I Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids uppS - 2.5.1.31 ko:K00806 ko00900,ko01110,map00900,map01110 - R06447 RC00279,RC02839 ko00000,ko00001,ko01000,ko01006 - - - Prenyltransf k59_58671_1 696747.NIES39_E02400 1.83e-15 82.8 COG3506@1|root,COG3507@1|root,COG5434@1|root,COG3506@2|Bacteria,COG3507@2|Bacteria,COG5434@2|Bacteria,1G0JG@1117|Cyanobacteria,1HADF@1150|Oscillatoriales 1117|Cyanobacteria M Pectate lyase superfamily protein - - - - - - - - - - - - DUF1349,DUF4347,Pectate_lyase_3 k59_679908_1 1122137.AQXF01000004_gene1690 2.61e-34 122.0 2ESRE@1|root,33K9T@2|Bacteria 2|Bacteria S Hpt domain - - - - - - - - - - - - Hpt k59_679908_2 1122962.AULH01000011_gene1124 8e-06 48.1 2E3VV@1|root,32YT1@2|Bacteria,1N8KB@1224|Proteobacteria,2UGY9@28211|Alphaproteobacteria,3715G@31993|Methylocystaceae 28211|Alphaproteobacteria S Protein of unknown function (DUF3253) - - - - - - - - - - - - DUF3253 k59_1753243_1 396588.Tgr7_2034 2.07e-63 214.0 COG3957@1|root,COG3957@2|Bacteria,1MVSE@1224|Proteobacteria,1RYC8@1236|Gammaproteobacteria,1WX4W@135613|Chromatiales 135613|Chromatiales G Transketolase central region - - - - - - - - - - - - XFP,XFP_N k59_510364_1 1089546.AQUI01000002_gene1835 4.53e-19 90.1 COG1071@1|root,COG1071@2|Bacteria,2IBRC@201174|Actinobacteria,407TR@622450|Actinopolysporales 201174|Actinobacteria C Dehydrogenase E1 component pdhA - 1.2.4.1 ko:K00161 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230 M00307 R00014,R00209,R01699,R03270 RC00004,RC00027,RC00627,RC02742,RC02744,RC02882 br01601,ko00000,ko00001,ko00002,ko01000 - - - E1_dh k59_171712_1 511145.b0055 1.86e-115 335.0 COG1076@1|root,COG1076@2|Bacteria,1N270@1224|Proteobacteria,1RP0P@1236|Gammaproteobacteria,3XMH7@561|Escherichia 1236|Gammaproteobacteria O Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host djlA GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0051087,GO:0071944 - ko:K05801 - - - - ko00000,ko03110 - - - DnaJ,TerB k59_227853_1 204669.Acid345_2716 2.41e-13 78.6 COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria 2|Bacteria U Involved in the tonB-independent uptake of proteins - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - PD40,Pkinase,WD40 k59_171713_1 945550.VISI1226_12036 1.01e-08 58.2 COG1028@1|root,COG1028@2|Bacteria,1MW9A@1224|Proteobacteria,1RMMZ@1236|Gammaproteobacteria,1XV9R@135623|Vibrionales 135623|Vibrionales IQ COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - - - - - - - - - - - adh_short_C2 k59_171713_2 1415780.JPOG01000001_gene587 1.09e-34 122.0 COG2146@1|root,COG2146@2|Bacteria,1N8PE@1224|Proteobacteria,1SEE6@1236|Gammaproteobacteria,1X8IV@135614|Xanthomonadales 135614|Xanthomonadales P Rieske [2Fe-2S] domain - - - - - - - - - - - - Rieske k59_397554_1 521460.Athe_1675 3.31e-11 67.0 COG1256@1|root,COG4786@1|root,COG1256@2|Bacteria,COG4786@2|Bacteria,1TPXH@1239|Firmicutes,249PE@186801|Clostridia,42F3N@68295|Thermoanaerobacterales 186801|Clostridia N TIGRFAM Flagellar hook-associated protein, FlgK flgK - - ko:K02396 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - Flg_bb_rod,Flg_bbr_C k59_397554_2 1437882.AZRU01000030_gene138 7.09e-12 71.2 COG1344@1|root,COG1344@2|Bacteria,1PJUJ@1224|Proteobacteria,1RPNR@1236|Gammaproteobacteria,1YCS1@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria N Bacterial flagellin N-terminal helical region flgL - - ko:K02397 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - Flagellin_C,Flagellin_N k59_679926_2 595494.Tola_2147 2.51e-19 90.5 COG0417@1|root,COG0417@2|Bacteria,1MVY9@1224|Proteobacteria,1RMQ1@1236|Gammaproteobacteria,1Y43X@135624|Aeromonadales 135624|Aeromonadales L DNA polymerase polB - 2.7.7.7 ko:K02336 - - - - ko00000,ko01000,ko03400 - - - DNA_pol_B,DNA_pol_B_exo1 k59_905706_1 985054.JQEZ01000004_gene648 6.83e-80 254.0 COG0076@1|root,COG0076@2|Bacteria,1MWUX@1224|Proteobacteria,2TTUK@28211|Alphaproteobacteria,4NA0F@97050|Ruegeria 28211|Alphaproteobacteria E Pyridoxal-dependent decarboxylase conserved domain ddc - 4.1.1.105,4.1.1.28 ko:K01593 ko00350,ko00360,ko00380,ko00901,ko00950,ko00965,ko01100,ko01110,ko04726,ko04728,ko05030,ko05031,ko05034,map00350,map00360,map00380,map00901,map00950,map00965,map01100,map01110,map04726,map04728,map05030,map05031,map05034 M00037,M00042 R00685,R00699,R00736,R02080,R02701,R04909 RC00299 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Pyridoxal_deC k59_905706_2 1268239.PALB_18470 8.15e-13 72.8 COG0834@1|root,COG0834@2|Bacteria,1N40W@1224|Proteobacteria,1S11U@1236|Gammaproteobacteria,2Q18Z@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria ET COG0834 ABC-type amino acid transport signal transduction systems, periplasmic component domain - - - ko:K02030 - M00236 - - ko00000,ko00002,ko02000 3.A.1.3 - - SBP_bac_3 k59_510384_1 926550.CLDAP_23290 3.4e-56 193.0 COG1132@1|root,COG1132@2|Bacteria,2G7J5@200795|Chloroflexi 200795|Chloroflexi V ABC transporter, transmembrane region - - - ko:K06147 - - - - ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran k59_1019172_1 1122137.AQXF01000001_gene2920 6.14e-21 88.6 COG1514@1|root,COG1514@2|Bacteria,1RDB2@1224|Proteobacteria,2U7FV@28211|Alphaproteobacteria 28211|Alphaproteobacteria J Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester ligT - 3.1.4.58 ko:K01975 - - - - ko00000,ko01000,ko03016 - - - LigT_PEase k59_1019172_2 1120950.KB892786_gene117 1.08e-72 239.0 COG3540@1|root,COG3540@2|Bacteria,2GJCI@201174|Actinobacteria,4DN41@85009|Propionibacteriales 201174|Actinobacteria P PhoD-like phosphatase, N-terminal domain phoD - 3.1.3.1 ko:K01113 ko00790,ko01100,ko02020,map00790,map01100,map02020 M00126 R04620 RC00017 ko00000,ko00001,ko00002,ko01000 - - - PhoD,PhoD_N k59_1245008_1 861299.J421_0783 2.78e-05 52.8 COG5002@1|root,COG5002@2|Bacteria 2|Bacteria T protein histidine kinase activity - - - - - - - - - - - - GAF_2,HATPase_c,HisKA,PAS,PAS_9,Response_reg k59_227857_1 1121406.JAEX01000018_gene2815 3.03e-37 139.0 COG0438@1|root,COG0438@2|Bacteria,1MU9C@1224|Proteobacteria,42R6N@68525|delta/epsilon subdivisions,2WPW4@28221|Deltaproteobacteria,2MCTH@213115|Desulfovibrionales 28221|Deltaproteobacteria M PFAM Glycosyl transferase, group 1 - - - - - - - - - - - - Glyco_transf_4,Glycos_transf_1 k59_227857_2 198628.Dda3937_03155 1.92e-24 97.4 COG1546@1|root,COG1546@2|Bacteria,1RH2Y@1224|Proteobacteria,1S5WH@1236|Gammaproteobacteria,2JCH6@204037|Dickeya 1236|Gammaproteobacteria S Belongs to the CinA family ygaD GO:0003674,GO:0003824,GO:0016787,GO:0016810,GO:0016811,GO:0019159 3.5.1.42 ko:K03743 ko00760,map00760 - R02322 RC00100 ko00000,ko00001,ko01000 - - - CinA k59_567132_2 1504981.KO116_1685 1.03e-51 183.0 COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,1RMQB@1236|Gammaproteobacteria,1XIF1@135619|Oceanospirillales 135619|Oceanospirillales S Tripartite tricarboxylate transporter TctA family - - - ko:K07793 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.80.1 - - TctA k59_510390_1 247639.MGP2080_00135 1.53e-89 281.0 COG3653@1|root,COG3653@2|Bacteria,1MWWY@1224|Proteobacteria 1224|Proteobacteria Q COG3653 N-acyl-D-aspartate D-glutamate deacylase dan - 3.5.1.81 ko:K06015 - - R02192 RC00064,RC00328 ko00000,ko01000 - - - Amidohydro_3 k59_793082_1 935840.JAEQ01000006_gene2616 1.21e-29 107.0 COG2963@1|root,COG2963@2|Bacteria,1RGZ5@1224|Proteobacteria,2UAIS@28211|Alphaproteobacteria,43KTK@69277|Phyllobacteriaceae 28211|Alphaproteobacteria L Transposase - - - - - - - - - - - - HTH_Tnp_1 k59_793082_2 981384.AEYW01000014_gene131 1.85e-84 255.0 COG2801@1|root,COG2801@2|Bacteria,1MVN5@1224|Proteobacteria,2TQK0@28211|Alphaproteobacteria,4NC5D@97050|Ruegeria 28211|Alphaproteobacteria L Integrase core domain - - - - - - - - - - - - HTH_21,rve,rve_3 k59_623430_1 653733.Selin_1750 4.64e-58 195.0 COG1916@1|root,COG1916@2|Bacteria 2|Bacteria - - traB - - - - - - - - - - - TraB k59_115266_1 702113.PP1Y_AT5252 3.87e-59 193.0 COG1062@1|root,COG1062@2|Bacteria,1MUK4@1224|Proteobacteria,2TUMG@28211|Alphaproteobacteria,2K338@204457|Sphingomonadales 204457|Sphingomonadales C Alcohol dehydrogenase GroES-like domain - - 1.1.1.90 ko:K00055 ko00350,ko00360,ko00622,ko00623,ko01100,ko01120,ko01220,map00350,map00360,map00622,map00623,map01100,map01120,map01220 M00537,M00538 R01763,R02611,R04304,R05282,R05347,R05348 RC00087,RC00116 ko00000,ko00001,ko00002,ko01000 - - - ADH_N,ADH_zinc_N k59_1197249_1 436308.Nmar_1707 6.92e-39 134.0 COG0125@1|root,arCOG01891@2157|Archaea,41T33@651137|Thaumarchaeota 651137|Thaumarchaeota F thymidylate kinase tmk - 2.7.4.9 ko:K00943 ko00240,ko01100,map00240,map01100 M00053 R02094,R02098 RC00002 ko00000,ko00001,ko00002,ko01000 - - - Thymidylate_kin k59_1197249_2 436308.Nmar_1706 4.16e-242 671.0 COG1078@1|root,arCOG04430@2157|Archaea,41T0P@651137|Thaumarchaeota 651137|Thaumarchaeota S Metal dependent phosphohydrolases with conserved 'HD' motif. - - - ko:K06885 - - - - ko00000 - - - HD k59_1197249_3 436308.Nmar_1705 5.05e-139 395.0 COG0528@1|root,arCOG00858@2157|Archaea,41T1R@651137|Thaumarchaeota 651137|Thaumarchaeota F Catalyzes the reversible phosphorylation of UMP to UDP pyrH - 2.7.4.22 ko:K09903 ko00240,ko01100,map00240,map01100 - R00158 RC00002 ko00000,ko00001,ko01000 - - - AA_kinase k59_1705431_1 1122137.AQXF01000006_gene952 3.93e-226 625.0 COG0202@1|root,COG0202@2|Bacteria,1MU75@1224|Proteobacteria,2TSI0@28211|Alphaproteobacteria 28211|Alphaproteobacteria K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoA GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006351,GO:0006354,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576 2.7.7.6 ko:K03040 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_A_CTD,RNA_pol_A_bac,RNA_pol_L k59_1592281_1 870187.Thini_4470 2.66e-39 146.0 COG4974@1|root,COG4974@2|Bacteria,1MVAN@1224|Proteobacteria,1RMSS@1236|Gammaproteobacteria,460A2@72273|Thiotrichales 72273|Thiotrichales L Belongs to the 'phage' integrase family - - - - - - - - - - - - Phage_int_SAM_4,Phage_integrase k59_1084090_2 33876.JNXY01000004_gene1737 2.32e-07 52.8 28THE@1|root,2ZFRB@2|Bacteria,2IQVF@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - - k59_1084090_5 1476876.JOJO01000002_gene6633 2.52e-23 114.0 2B5CX@1|root,31Y73@2|Bacteria,2H0BC@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - - k59_1084090_8 1499967.BAYZ01000197_gene3065 6.98e-63 236.0 COG5283@1|root,COG5412@1|root,COG5283@2|Bacteria,COG5412@2|Bacteria 2|Bacteria N phage tail tape measure protein - - - - - - - - - - - - PhageMin_Tail,SLT k59_915576_1 1144305.PMI02_03964 1.28e-53 174.0 COG2135@1|root,COG2135@2|Bacteria,1RHFV@1224|Proteobacteria,2UA66@28211|Alphaproteobacteria,2K5CJ@204457|Sphingomonadales 204457|Sphingomonadales S SOS response associated peptidase (SRAP) - - - - - - - - - - - - SRAP k59_1763059_1 565045.NOR51B_1319 6.08e-22 104.0 COG4773@1|root,COG4773@2|Bacteria,1QTXJ@1224|Proteobacteria,1T2BS@1236|Gammaproteobacteria,1J84P@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M P COG1629 Outer membrane receptor proteins, mostly Fe transport - - - - - - - - - - - - Plug,TonB_dep_Rec k59_971552_1 1122915.AUGY01000004_gene5459 1.6e-09 61.2 COG2207@1|root,COG2207@2|Bacteria,1UZXQ@1239|Firmicutes,4IQ01@91061|Bacilli,2765J@186822|Paenibacillaceae 91061|Bacilli K helix_turn_helix, arabinose operon control protein - - - - - - - - - - - - HTH_18 k59_1481567_2 436308.Nmar_0052 7.46e-130 371.0 COG0177@1|root,arCOG00459@2157|Archaea,41SFM@651137|Thaumarchaeota 651137|Thaumarchaeota L DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate nth - 4.2.99.18 ko:K10773 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - HhH-GPD k59_1085013_1 497964.CfE428DRAFT_3883 2.59e-35 126.0 COG0852@1|root,COG0852@2|Bacteria,46STM@74201|Verrucomicrobia 74201|Verrucomicrobia C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoC - 1.6.5.3 ko:K00332 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_30kDa k59_1085013_2 981369.JQMJ01000004_gene3405 1.86e-07 52.8 COG0649@1|root,COG0649@2|Bacteria,2GKEZ@201174|Actinobacteria,2NEP1@228398|Streptacidiphilus 201174|Actinobacteria C Respiratory-chain NADH dehydrogenase, 49 Kd subunit nuoD GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 1.6.5.3 ko:K00333 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_49kDa k59_12228_1 1121033.AUCF01000010_gene4424 1.91e-51 177.0 COG0174@1|root,COG0174@2|Bacteria,1MU6V@1224|Proteobacteria,2TRCP@28211|Alphaproteobacteria,2JQHA@204441|Rhodospirillales 204441|Rhodospirillales E Glutamine synthetase, catalytic domain - - 6.3.1.2 ko:K01915 ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 - R00253 RC00010,RC02798 ko00000,ko00001,ko01000,ko04147 - - - Gln-synt_C k59_633222_1 1453505.JASY01000005_gene1575 1.58e-36 132.0 COG0457@1|root,COG0457@2|Bacteria,4PFCX@976|Bacteroidetes,1I8UB@117743|Flavobacteriia,2NYB3@237|Flavobacterium 976|Bacteroidetes S Tetratricopeptide repeat - - - - - - - - - - - - - k59_1198227_1 546271.Selsp_1636 9.89e-06 48.1 COG0824@1|root,COG0824@2|Bacteria,1VAGM@1239|Firmicutes,4H4IS@909932|Negativicutes 909932|Negativicutes S acyl-CoA thioester hydrolase, YbgC YbaW family - - - ko:K07107 - - - - ko00000,ko01000 - - - 4HBT,4HBT_2 k59_1198227_2 1122218.KB893654_gene2040 1.79e-16 77.0 COG1186@1|root,COG1186@2|Bacteria,1RH75@1224|Proteobacteria,2U9M7@28211|Alphaproteobacteria,1JUJ6@119045|Methylobacteriaceae 28211|Alphaproteobacteria J Class I peptide chain release factor MA20_05665 GO:0003674,GO:0003676,GO:0003723,GO:0003747,GO:0003824,GO:0004045,GO:0005488,GO:0006412,GO:0006414,GO:0006415,GO:0006417,GO:0006518,GO:0006807,GO:0008079,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010608,GO:0016043,GO:0016150,GO:0016787,GO:0016788,GO:0019222,GO:0019538,GO:0022411,GO:0031323,GO:0031326,GO:0032268,GO:0032984,GO:0034248,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044877,GO:0050789,GO:0050794,GO:0051171,GO:0051246,GO:0052689,GO:0060255,GO:0065007,GO:0071704,GO:0071840,GO:0072344,GO:0080090,GO:0097159,GO:0140098,GO:0140101,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:2000112 - ko:K15034 - - - - ko00000,ko03012 - - - RF-1 k59_689652_1 10228.TriadP20563 3.9e-19 95.9 COG0488@1|root,KOG0066@2759|Eukaryota,3AHFX@33154|Opisthokonta,3B9N7@33208|Metazoa 33208|Metazoa J translation activator activity ABCF1 GO:0000166,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005635,GO:0005654,GO:0005737,GO:0005829,GO:0005840,GO:0005844,GO:0006412,GO:0006413,GO:0006417,GO:0006518,GO:0006807,GO:0006810,GO:0006950,GO:0006952,GO:0006954,GO:0008135,GO:0008144,GO:0008150,GO:0008152,GO:0008494,GO:0009058,GO:0009059,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0012505,GO:0017076,GO:0019222,GO:0019538,GO:0030554,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031967,GO:0031974,GO:0031975,GO:0031981,GO:0032268,GO:0032270,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0034248,GO:0034250,GO:0034641,GO:0034645,GO:0035639,GO:0036094,GO:0042788,GO:0043021,GO:0043022,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044422,GO:0044424,GO:0044428,GO:0044444,GO:0044446,GO:0044464,GO:0044877,GO:0045182,GO:0045727,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051179,GO:0051234,GO:0051246,GO:0051247,GO:0055085,GO:0060255,GO:0065007,GO:0070013,GO:0071704,GO:0080090,GO:0090079,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904,GO:2000112 - ko:K06184 - - - - ko00000,ko03012 - - - ABC_tran,ABC_tran_Xtn k59_1368261_1 1219045.BV98_000638 1.15e-29 107.0 COG3041@1|root,COG3041@2|Bacteria,1N0K0@1224|Proteobacteria,2UC2Y@28211|Alphaproteobacteria,2K6W6@204457|Sphingomonadales 204457|Sphingomonadales S Addiction module - - - ko:K19157 - - - - ko00000,ko01000,ko02048 - - - YafQ_toxin k59_69153_1 926569.ANT_31640 2.51e-83 251.0 COG1573@1|root,COG1573@2|Bacteria,2G6BR@200795|Chloroflexi 200795|Chloroflexi L TIGRFAM phage SPO1 DNA polymerase-related protein - - 3.2.2.27 ko:K21929 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - UDG k59_181530_1 376686.Fjoh_4432 1.36e-61 204.0 28JXB@1|root,2Z9MU@2|Bacteria,4NJB5@976|Bacteroidetes,1I990@117743|Flavobacteriia,2NXFY@237|Flavobacterium 976|Bacteroidetes S Outer membrane protein SusF_SusE - - - ko:K21571 - - - - ko00000 - - - SusE,SusF_SusE k59_1423849_1 414684.RC1_3894 3.02e-63 211.0 COG3182@1|root,COG3182@2|Bacteria,1MVET@1224|Proteobacteria,2U200@28211|Alphaproteobacteria,2JUDG@204441|Rhodospirillales 204441|Rhodospirillales S PepSY-associated TM region - - - - - - - - - - - - PepSY_TM k59_1763087_1 1122137.AQXF01000005_gene1101 4.82e-131 379.0 COG2189@1|root,COG2189@2|Bacteria,1MX9M@1224|Proteobacteria,2TSW9@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Belongs to the N(4) N(6)-methyltransferase family ccrM - 2.1.1.72 ko:K13581 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko02048 - - - N6_N4_Mtase k59_463809_1 1097668.BYI23_C010890 8.42e-24 102.0 COG0477@1|root,COG2814@2|Bacteria,1MW6T@1224|Proteobacteria,2VMDP@28216|Betaproteobacteria,1K2PV@119060|Burkholderiaceae 28216|Betaproteobacteria EGP Major facilitator superfamily MFS_1 - - - - - - - - - - - - MFS_4 k59_803303_1 1172180.KB911779_gene5566 2.11e-81 249.0 COG0270@1|root,COG0270@2|Bacteria,2GNB2@201174|Actinobacteria 201174|Actinobacteria L DNA (cytosine-5-)-methyltransferase activity - - - - - - - - - - - - - k59_12245_1 316407.1651409 2.38e-131 388.0 COG4988@1|root,COG4988@2|Bacteria,1QU1N@1224|Proteobacteria,1RNPI@1236|Gammaproteobacteria,3XMAN@561|Escherichia 1236|Gammaproteobacteria P ATP-binding cydD GO:0000101,GO:0003333,GO:0003674,GO:0003824,GO:0005215,GO:0005319,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006857,GO:0006865,GO:0006869,GO:0008150,GO:0009987,GO:0010876,GO:0015399,GO:0015405,GO:0015711,GO:0015804,GO:0015833,GO:0015849,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019725,GO:0022804,GO:0022857,GO:0031224,GO:0031226,GO:0032973,GO:0032991,GO:0033036,GO:0033228,GO:0034040,GO:0034220,GO:0034635,GO:0034775,GO:0035443,GO:0035672,GO:0042592,GO:0042623,GO:0042626,GO:0042883,GO:0042886,GO:0042939,GO:0043190,GO:0043492,GO:0044425,GO:0044459,GO:0044464,GO:0045454,GO:0046942,GO:0050789,GO:0050794,GO:0051179,GO:0051181,GO:0051234,GO:0055085,GO:0065007,GO:0065008,GO:0071702,GO:0071705,GO:0071944,GO:0072337,GO:0072348,GO:0098533,GO:0098655,GO:0098656,GO:0098796,GO:0098797,GO:0140115,GO:1902494,GO:1902495,GO:1903712,GO:1903825,GO:1904949,GO:1905039,GO:1990351 - ko:K16013 ko02010,map02010 - - - ko00000,ko00001,ko02000 3.A.1.129 - iEC042_1314.EC042_0979,iECUMN_1333.ECUMN_1082,iETEC_1333.ETEC_0955 ABC_membrane,ABC_tran k59_1085028_2 1163409.UUA_10266 2.06e-25 104.0 COG0324@1|root,COG0324@2|Bacteria,1MUB2@1224|Proteobacteria,1RMDU@1236|Gammaproteobacteria,1X3TF@135614|Xanthomonadales 135614|Xanthomonadales J Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) miaA GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016765,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0052381,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.5.1.75 ko:K00791 ko00908,ko01100,ko01110,map00908,map01100,map01110 - R01122 RC02820 ko00000,ko00001,ko01000,ko01006,ko03016 - - - IPPT k59_1706328_1 316407.21238998 1.77e-80 240.0 COG0801@1|root,COG0801@2|Bacteria,1MZH8@1224|Proteobacteria,1S63J@1236|Gammaproteobacteria,3XMN2@561|Escherichia 1236|Gammaproteobacteria H 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity folK GO:0000287,GO:0003674,GO:0003824,GO:0003848,GO:0005488,GO:0016740,GO:0016772,GO:0016778,GO:0043167,GO:0043169,GO:0046872 2.7.6.3 ko:K00950 ko00790,ko01100,map00790,map01100 M00126,M00841 R03503 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - iECDH1ME8569_1439.ECDH1ME8569_0136,iEcDH1_1363.EcDH1_3460,iJN746.PP_4698,iSBO_1134.SBO_0131 HPPK k59_1706328_2 199310.c0176 4.46e-57 189.0 COG0617@1|root,COG0617@2|Bacteria,1MVCS@1224|Proteobacteria,1RMBG@1236|Gammaproteobacteria,3XNZM@561|Escherichia 1236|Gammaproteobacteria F Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control pcnB GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0004652,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006276,GO:0006378,GO:0006396,GO:0006397,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016740,GO:0016772,GO:0016779,GO:0031123,GO:0031124,GO:0034641,GO:0043170,GO:0043412,GO:0043631,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070566,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363 2.7.7.19 ko:K00970 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - PolyA_pol,PolyA_pol_RNAbd,PolyA_pol_arg_C k59_860132_1 706587.Desti_5255 9.34e-85 280.0 COG0086@1|root,COG0086@2|Bacteria,1MU3M@1224|Proteobacteria,42NAW@68525|delta/epsilon subdivisions,2WISU@28221|Deltaproteobacteria,2MR5Q@213462|Syntrophobacterales 28221|Deltaproteobacteria K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoC - 2.7.7.6 ko:K03046 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5 k59_519912_1 1121935.AQXX01000124_gene97 8.38e-19 90.9 COG0457@1|root,COG3712@1|root,COG4773@1|root,COG0457@2|Bacteria,COG3712@2|Bacteria,COG4773@2|Bacteria,1RJUD@1224|Proteobacteria,1S0ET@1236|Gammaproteobacteria 1236|Gammaproteobacteria PT FecR protein - - - - - - - - - - - - FecR,TPR_16,TPR_19,TonB_dep_Rec k59_294973_1 1082932.ATCR1_06741 4.59e-66 217.0 COG5323@1|root,COG5323@2|Bacteria,1R049@1224|Proteobacteria 1224|Proteobacteria S Terminase RNaseH-like domain - - - - - - - - - - - - Terminase_6 k59_803323_1 436308.Nmar_0710 9.8e-23 89.7 COG1522@1|root,arCOG01117@2157|Archaea 2157|Archaea K COG1522 Transcriptional regulators - - - - - - - - - - - - AsnC_trans_reg k59_1368295_1 870187.Thini_2353 2.22e-33 125.0 2DNXC@1|root,32ZN4@2|Bacteria,1NKWP@1224|Proteobacteria,1SH3A@1236|Gammaproteobacteria,463C1@72273|Thiotrichales 72273|Thiotrichales - - - - - - - - - - - - - - - k59_1311681_1 205918.Psyr_1716 2.93e-38 146.0 COG0457@1|root,COG0457@2|Bacteria,1MXK4@1224|Proteobacteria,1RNFM@1236|Gammaproteobacteria,1Z5M5@136849|Pseudomonas syringae group 1236|Gammaproteobacteria S Oxygen tolerance batD - - - - - - - - - - - BatD k59_971597_2 1254432.SCE1572_03995 1.07e-64 216.0 COG2114@1|root,COG3322@1|root,COG2114@2|Bacteria,COG3322@2|Bacteria,1QWNC@1224|Proteobacteria,42ZRB@68525|delta/epsilon subdivisions,2WV1J@28221|Deltaproteobacteria,2YV0C@29|Myxococcales 28221|Deltaproteobacteria T Belongs to the adenylyl cyclase class-4 guanylyl cyclase family - - 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 - - - CHASE4,Guanylate_cyc k59_633269_1 1122137.AQXF01000005_gene1329 1.2e-86 257.0 COG1522@1|root,COG1522@2|Bacteria,1RDB3@1224|Proteobacteria,2UAFU@28211|Alphaproteobacteria 28211|Alphaproteobacteria K helix_turn_helix ASNC type - - - - - - - - - - - - AsnC_trans_reg k59_181548_2 392500.Swoo_0299 4.86e-44 147.0 COG0494@1|root,COG0494@2|Bacteria,1RCZM@1224|Proteobacteria,1RS3S@1236|Gammaproteobacteria,2QC89@267890|Shewanellaceae 1236|Gammaproteobacteria L Nudix hydrolase mutT GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008413,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017110,GO:0030145,GO:0033554,GO:0034641,GO:0035539,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044715,GO:0044716,GO:0046483,GO:0046872,GO:0046914,GO:0047429,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360 3.6.1.55 ko:K03574 - - - - ko00000,ko01000,ko03400 - - iE2348C_1286.E2348C_0104,iSDY_1059.SDY_0129 NUDIX,NUDIX_4,TMP-TENI k59_294982_1 391603.FBALC1_14117 9.29e-133 394.0 COG2987@1|root,COG2987@2|Bacteria,4NF2P@976|Bacteroidetes,1HXQQ@117743|Flavobacteriia 976|Bacteroidetes E Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate hutU - 4.2.1.49 ko:K01712 ko00340,ko01100,map00340,map01100 M00045 R02914 RC00804 ko00000,ko00001,ko00002,ko01000 - - - Urocanase,Urocanase_C,Urocanase_N k59_1141618_1 525904.Tter_2373 4.32e-39 142.0 COG3394@1|root,COG3394@2|Bacteria 2|Bacteria G polysaccharide catabolic process - - 3.5.1.105 ko:K03478 - - - - ko00000,ko01000 - - - YdjC k59_1029829_1 627192.SLG_27430 2.13e-54 177.0 COG3812@1|root,COG3812@2|Bacteria,1RGUV@1224|Proteobacteria,2U9BA@28211|Alphaproteobacteria,2K5DU@204457|Sphingomonadales 204457|Sphingomonadales S Domain of unknown function (DUF1993) - - - ko:K09983 - - - - ko00000 - - - DUF1993 k59_633289_1 565045.NOR51B_1272 9.2e-09 67.4 COG1119@1|root,COG1119@2|Bacteria,1QVPR@1224|Proteobacteria,1SKAF@1236|Gammaproteobacteria 1236|Gammaproteobacteria P ATPase activity - - - - - - - - - - - - - k59_407504_1 644966.Tmar_1086 3.33e-18 86.3 COG0604@1|root,COG0604@2|Bacteria,1TQ0M@1239|Firmicutes,24IX8@186801|Clostridia,3WDCB@538999|Clostridiales incertae sedis 186801|Clostridia C Zinc-binding dehydrogenase - - 1.6.5.5 ko:K00344 - - - - ko00000,ko01000 - - - ADH_N,ADH_zinc_N,ADH_zinc_N_2 k59_1254862_1 231434.JQJH01000011_gene3170 1.62e-06 55.1 COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,2TR80@28211|Alphaproteobacteria,3NAW2@45404|Beijerinckiaceae 28211|Alphaproteobacteria P YHS domain - - 3.6.3.54 ko:K17686 ko01524,ko04016,map01524,map04016 - R00086 RC00002 ko00000,ko00001,ko01000 3.A.3.5 - - E1-E2_ATPase,Hydrolase,YHS k59_1254862_2 1304880.JAGB01000001_gene662 1.78e-67 224.0 COG0282@1|root,COG0282@2|Bacteria,1TQ22@1239|Firmicutes,248ZM@186801|Clostridia 186801|Clostridia F Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction ackA - 2.7.2.1 ko:K00925 ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200 M00357,M00579 R00315,R01353 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - Acetate_kinase k59_1650431_1 929558.SMGD1_1421 3.34e-44 163.0 COG3391@1|root,COG3391@2|Bacteria,1QYKD@1224|Proteobacteria,43E97@68525|delta/epsilon subdivisions,2YSSS@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria C Cytochrome c554 and c-prime - - - - - - - - - - - - Cytochrome_C554 k59_633305_1 377629.TERTU_3437 1.53e-60 192.0 arCOG03638@1|root,2Z7NN@2|Bacteria,1R3Y6@1224|Proteobacteria,1RTWY@1236|Gammaproteobacteria,2PPR1@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria S Protein of unknown function (DUF1538) - - - - - - - - - - - - DUF1538 k59_1706367_1 314278.NB231_05195 3.99e-196 549.0 COG3677@1|root,COG3677@2|Bacteria,1NUTK@1224|Proteobacteria,1S11R@1236|Gammaproteobacteria,1WZ4K@135613|Chromatiales 135613|Chromatiales L ISXO2-like transposase domain - - - - - - - - - - - - DDE_Tnp_IS1595,Zn_Tnp_IS1595 k59_1141651_1 1125863.JAFN01000001_gene182 2.2e-157 454.0 COG0685@1|root,COG0685@2|Bacteria,1NB3G@1224|Proteobacteria,42P1W@68525|delta/epsilon subdivisions,2WKDD@28221|Deltaproteobacteria 28221|Deltaproteobacteria E Methylene-tetrahydrofolate reductase C terminal - - 1.5.1.20 ko:K00297 ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,map00670,map00720,map01100,map01120,map01200,map01523 M00377 R01224,R07168 RC00081 ko00000,ko00001,ko00002,ko01000 - - - MTHFR,MTHFR_C k59_689713_1 436308.Nmar_1297 9.6e-29 111.0 COG1798@1|root,COG1849@1|root,arCOG01224@2157|Archaea,arCOG04161@2157|Archaea,41SC2@651137|Thaumarchaeota 651137|Thaumarchaeota H diphthine synthase - - 2.1.1.98 ko:K20215 - - R04481,R08468,R08469,R10306 RC00003,RC00190,RC01155,RC02136,RC02308 ko00000,ko01000 - - - DUF357,TP_methylase k59_689713_2 436308.Nmar_1298 2.32e-35 126.0 COG0615@1|root,arCOG01222@2157|Archaea,41SPR@651137|Thaumarchaeota 651137|Thaumarchaeota M Cytidylyltransferase-like - - 2.7.7.2,2.7.7.39 ko:K00980,ko:K14656 ko00564,ko00740,ko01100,ko01110,map00564,map00740,map01100,map01110 - R00161,R00856 RC00002 ko00000,ko00001,ko01000 - - - CTP_transf_like k59_237604_1 1282360.ABAC460_08245 9.97e-06 44.7 COG0776@1|root,COG0776@2|Bacteria,1MZ7M@1224|Proteobacteria,2UBR5@28211|Alphaproteobacteria,2KGZD@204458|Caulobacterales 204458|Caulobacterales K This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control himD - - ko:K05788 - - - - ko00000,ko03032,ko03036,ko03400 - - - Bac_DNA_binding k59_237604_2 1528106.JRJE01000032_gene2664 0.000338 45.4 COG5416@1|root,COG5416@2|Bacteria 2|Bacteria FG Lipopolysaccharide assembly protein A domain - - - ko:K08992 - - - - ko00000 - - - LapA_dom k59_181588_1 1469607.KK073769_gene6074 1.98e-81 253.0 COG3293@1|root,COG3293@2|Bacteria,1G0BW@1117|Cyanobacteria,1HNSC@1161|Nostocales 1117|Cyanobacteria L transposase - - - ko:K07492 - - - - ko00000 - - - DDE_Tnp_1,DDE_Tnp_1_2,DUF4096 k59_1368364_1 1195246.AGRI_15010 2.13e-91 282.0 COG1904@1|root,COG1904@2|Bacteria,1MVRI@1224|Proteobacteria,1RMRR@1236|Gammaproteobacteria,464VQ@72275|Alteromonadaceae 1236|Gammaproteobacteria G Glucuronate isomerase uxaC GO:0005975,GO:0005996,GO:0006063,GO:0006064,GO:0006082,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016052,GO:0016054,GO:0019585,GO:0019586,GO:0019698,GO:0019752,GO:0032787,GO:0042839,GO:0042840,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0046365,GO:0046395,GO:0046396,GO:0046397,GO:0071704,GO:0072329,GO:1901575 5.3.1.12 ko:K01812 ko00040,ko01100,map00040,map01100 M00061,M00631 R01482,R01983 RC00376 ko00000,ko00001,ko00002,ko01000 - - iPC815.YPO0579,iSbBS512_1146.SbBS512_E3528 UxaC k59_1141671_2 1088721.NSU_2925 1.34e-55 188.0 COG0173@1|root,COG0173@2|Bacteria,1MUXB@1224|Proteobacteria,2TR9U@28211|Alphaproteobacteria,2K0PT@204457|Sphingomonadales 204457|Sphingomonadales J Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) aspS - 6.1.1.12 ko:K01876 ko00970,map00970 M00359,M00360 R05577 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - GAD,tRNA-synt_2,tRNA_anti-codon k59_295022_1 323848.Nmul_A1898 1.69e-77 234.0 COG2165@1|root,COG2165@2|Bacteria,1RDX2@1224|Proteobacteria,2VR7N@28216|Betaproteobacteria,3743R@32003|Nitrosomonadales 28216|Betaproteobacteria U Type II secretion system (T2SS), protein G gspG - - ko:K02456 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - N_methyl,T2SSG k59_915654_2 1254432.SCE1572_21130 2.05e-32 129.0 COG2303@1|root,COG2303@2|Bacteria,1MV19@1224|Proteobacteria,42N4C@68525|delta/epsilon subdivisions,2WJIH@28221|Deltaproteobacteria,2YZWU@29|Myxococcales 28221|Deltaproteobacteria E GMC oxidoreductase - - 1.1.99.1 ko:K00108 ko00260,ko01100,map00260,map01100 M00555 R01025 RC00087 ko00000,ko00001,ko00002,ko01000 - - - GMC_oxred_C,GMC_oxred_N k59_1198302_1 158500.BV97_04842 5.14e-78 241.0 COG0494@1|root,COG0494@2|Bacteria,1NTFG@1224|Proteobacteria,2U0I4@28211|Alphaproteobacteria,2KEFS@204457|Sphingomonadales 204457|Sphingomonadales L NUDIX domain - - - - - - - - - - - - NUDIX k59_1198303_1 1205753.A989_05198 9.3e-64 218.0 COG2366@1|root,COG2366@2|Bacteria,1MVMH@1224|Proteobacteria,1RPRP@1236|Gammaproteobacteria,1X56U@135614|Xanthomonadales 135614|Xanthomonadales S Penicillin acylase - - 3.5.1.11 ko:K01434 ko00311,ko01130,map00311,map01130 - R02170 RC00166,RC00328 ko00000,ko00001,ko01000,ko01002 - - - Penicil_amidase k59_1368399_1 436308.Nmar_0071 1e-66 204.0 COG2125@1|root,arCOG01946@2157|Archaea,41SPC@651137|Thaumarchaeota 651137|Thaumarchaeota J Belongs to the eukaryotic ribosomal protein eS6 family rps6e - - ko:K02991 ko01521,ko03010,ko04066,ko04150,ko04151,ko04371,ko04714,ko04910,ko05205,map01521,map03010,map04066,map04150,map04151,map04371,map04714,map04910,map05205 M00177,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S6e k59_971699_1 481805.EcolC_0975 2.74e-127 371.0 COG3395@1|root,COG3395@2|Bacteria,1MW4G@1224|Proteobacteria,1RN8I@1236|Gammaproteobacteria,3XN2W@561|Escherichia 1236|Gammaproteobacteria S kinase activity ygbK - 2.7.1.217,2.7.1.219,2.7.1.220 ko:K21948,ko:K22129 - - R11706,R11707 - ko00000,ko01000 - - - DUF1357_C,DUF1537 k59_576933_1 1082705.JIBP01000019_gene1043 7.17e-30 115.0 COG0235@1|root,COG0235@2|Bacteria,1RE8T@1224|Proteobacteria,1S3UF@1236|Gammaproteobacteria 1236|Gammaproteobacteria E Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) mtnB - 4.1.1.104,4.2.1.109 ko:K08964,ko:K22130 ko00270,ko01100,map00270,map01100 M00034 R07392 RC01939 ko00000,ko00001,ko00002,ko01000 - - - Aldolase_II k59_576933_2 1123487.KB892834_gene2666 1e-23 100.0 COG0008@1|root,COG0008@2|Bacteria,1MUN7@1224|Proteobacteria,2VHYK@28216|Betaproteobacteria,2KV7X@206389|Rhodocyclales 206389|Rhodocyclales J Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon gluQ - - ko:K01894 - - - - ko00000,ko01000,ko01007,ko03016 - - - tRNA-synt_1c k59_803430_1 1122137.AQXF01000003_gene2297 1e-102 312.0 COG0206@1|root,COG0206@2|Bacteria,1MV2X@1224|Proteobacteria,2TS1Q@28211|Alphaproteobacteria 28211|Alphaproteobacteria D Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity ftsZ - - ko:K03531 ko04112,map04112 - - - ko00000,ko00001,ko02048,ko03036,ko04812 - - - FtsZ_C,Tubulin k59_351498_1 745014.OMB55_00020300 4.97e-71 218.0 COG0252@1|root,COG0252@2|Bacteria,1RHAW@1224|Proteobacteria,1S5WS@1236|Gammaproteobacteria,1J6RP@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria EJ COG0252 L-asparaginase archaeal Glu-tRNAGln amidotransferase subunit D VL23_12675 - 3.5.1.1 ko:K01424 ko00250,ko00460,ko01100,ko01110,map00250,map00460,map01100,map01110 - R00485 RC00010,RC02798 ko00000,ko00001,ko01000 - - - Asparaginase k59_1311790_1 859657.RPSI07_mp0920 2.24e-162 482.0 COG0243@1|root,COG0243@2|Bacteria,1MX0A@1224|Proteobacteria,2VI0G@28216|Betaproteobacteria,1KBQ7@119060|Burkholderiaceae 28216|Betaproteobacteria C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family aoxB - 1.20.2.1,1.20.9.1 ko:K08356 - - - - ko00000,ko01000,ko02000 5.A.3.6 - - Molybdopterin,Molydop_binding k59_69294_1 1122225.AULQ01000005_gene2565 4.64e-172 513.0 COG1197@1|root,COG1197@2|Bacteria,4NEPA@976|Bacteroidetes,1HWS4@117743|Flavobacteriia 976|Bacteroidetes L Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site mfd - - ko:K03723 ko03420,map03420 - - - ko00000,ko00001,ko01000,ko03400 - - - CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF k59_1368409_1 232346.JHQL01000002_gene1297 2.71e-65 213.0 COG0165@1|root,COG0165@2|Bacteria,1MUTU@1224|Proteobacteria,1RMA3@1236|Gammaproteobacteria,1XH3Y@135619|Oceanospirillales 135619|Oceanospirillales E argininosuccinate lyase argH - 4.3.2.1 ko:K01755 ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230 M00029,M00844,M00845 R01086 RC00445,RC00447 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ASL_C2,Lyase_1 k59_746149_1 1121098.HMPREF1534_02855 5.58e-72 231.0 COG0232@1|root,COG0232@2|Bacteria,4NENM@976|Bacteroidetes,2FP36@200643|Bacteroidia,4AN4S@815|Bacteroidaceae 976|Bacteroidetes F Psort location Cytoplasmic, score dgt - 3.1.5.1 ko:K01129 ko00230,map00230 - R01856 RC00017 ko00000,ko00001,ko01000 - - - HD,HD_assoc k59_407601_1 402626.Rpic_2803 2.04e-64 202.0 COG0605@1|root,COG0605@2|Bacteria,1MVW2@1224|Proteobacteria,2VI2Y@28216|Betaproteobacteria,1K0TN@119060|Burkholderiaceae 28216|Betaproteobacteria C Destroys radicals which are normally produced within the cells and which are toxic to biological systems sodB GO:0000302,GO:0000303,GO:0000305,GO:0003674,GO:0003824,GO:0004784,GO:0006801,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0010035,GO:0016209,GO:0016491,GO:0016721,GO:0019430,GO:0033554,GO:0034599,GO:0034614,GO:0042221,GO:0044237,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0071450,GO:0071451,GO:0072593,GO:0097237,GO:0098754,GO:0098869,GO:1901700,GO:1901701,GO:1990748 1.15.1.1,3.1.11.6 ko:K03601,ko:K04564 ko03430,ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map03430,map04013,map04068,map04146,map04211,map04212,map04213,map05016 - - - ko00000,ko00001,ko01000,ko03400 - - - Sod_Fe_C,Sod_Fe_N k59_407601_2 517722.AEUE01000006_gene1971 4.97e-23 98.6 COG0471@1|root,COG0471@2|Bacteria,1MU0K@1224|Proteobacteria,2TSFS@28211|Alphaproteobacteria,2K30T@204457|Sphingomonadales 204457|Sphingomonadales P Transporter - - - - - - - - - - - - CitMHS,TrkA_C k59_125267_1 436308.Nmar_1566 2.13e-93 276.0 COG1096@1|root,arCOG00676@2157|Archaea,41SQA@651137|Thaumarchaeota 651137|Thaumarchaeota J Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs csl4 - - ko:K07573 ko03018,map03018 M00390,M00391 - - ko00000,ko00001,ko00002,ko03019 - - - - k59_1423971_1 1121035.AUCH01000004_gene282 8.82e-12 66.6 2AQI0@1|root,31FQP@2|Bacteria,1RI31@1224|Proteobacteria,2VUDX@28216|Betaproteobacteria,2KYD2@206389|Rhodocyclales 206389|Rhodocyclales - - - - - - - - - - - - - - - k59_463946_1 1056820.KB900696_gene4020 8.19e-76 241.0 COG1866@1|root,COG1866@2|Bacteria,1MWXN@1224|Proteobacteria,1RPM0@1236|Gammaproteobacteria,2PQ8S@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria H Phosphoenolpyruvate carboxykinase pckA GO:0003674,GO:0003824,GO:0004611,GO:0004612,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006094,GO:0008150,GO:0008152,GO:0009058,GO:0016051,GO:0016829,GO:0016830,GO:0016831,GO:0019318,GO:0019319,GO:0044238,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046364,GO:0071704,GO:1901576 4.1.1.49 ko:K01610 ko00010,ko00020,ko00620,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00710,map01100,map01110,map01120,map01130,map01200 M00003,M00170 R00341 RC00002,RC02741 ko00000,ko00001,ko00002,ko01000 - - - PEPCK_ATP k59_181628_1 1424334.W822_22380 2.3e-42 143.0 COG1666@1|root,COG1666@2|Bacteria,1RDTF@1224|Proteobacteria,2VPZU@28216|Betaproteobacteria,3T3GD@506|Alcaligenaceae 28216|Betaproteobacteria S nucleotide binding property based on structural studies of Haemophilus influenzae crystallized protein in PDB Accession Number 1IN0 and NMR studies of Escherichia coli YajQ yajQ - - ko:K09767 - - - - ko00000 - - - DUF520 k59_77915_1 237368.SCABRO_03057 2.44e-41 150.0 COG0438@1|root,COG0438@2|Bacteria 2|Bacteria M transferase activity, transferring glycosyl groups - - - ko:K00754 - - - - ko00000,ko01000 - GT4 - Glyco_trans_1_4,Glyco_trans_4_2,Glyco_transf_4,Glycos_transf_1 k59_1432144_1 99598.Cal7507_2523 5.7e-35 137.0 COG2374@1|root,COG2374@2|Bacteria,1GQK9@1117|Cyanobacteria,1HTQZ@1161|Nostocales 1117|Cyanobacteria S Protein of unknown function (DUF3616) - - - ko:K07004 - - - - ko00000 - - - - k59_754371_1 1121918.ARWE01000001_gene825 2.94e-86 266.0 COG0151@1|root,COG0151@2|Bacteria,1MUAH@1224|Proteobacteria,42MCI@68525|delta/epsilon subdivisions,2WJ7H@28221|Deltaproteobacteria,43SXY@69541|Desulfuromonadales 28221|Deltaproteobacteria F Phosphoribosylglycinamide synthetase, C domain purD - 6.3.4.13 ko:K01945 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04144 RC00090,RC00166 ko00000,ko00001,ko00002,ko01000 - - - AIRC,GARS_A,GARS_C,GARS_N k59_1771302_1 1232410.KI421424_gene1738 3.23e-75 244.0 COG0556@1|root,COG0556@2|Bacteria,1MUFK@1224|Proteobacteria,42MFA@68525|delta/epsilon subdivisions,2WJ20@28221|Deltaproteobacteria,43S6K@69541|Desulfuromonadales 28221|Deltaproteobacteria L Ultra-violet resistance protein B uvrB - - ko:K03702 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - Helicase_C,ResIII,UVR,UvrB k59_1038402_1 412965.COSY_0037 3.07e-61 199.0 COG1845@1|root,COG1845@2|Bacteria,1MUCK@1224|Proteobacteria,1RN9D@1236|Gammaproteobacteria,1J4UE@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C COG1845 Heme copper-type cytochrome quinol oxidase, subunit 3 coxC - 1.9.3.1 ko:K02276 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.4,3.D.4.6 - - COX3 k59_1602305_1 864051.BurJ1DRAFT_3613 3.06e-96 290.0 COG0604@1|root,COG0604@2|Bacteria,1MX8A@1224|Proteobacteria,2VHCB@28216|Betaproteobacteria,1KJ1A@119065|unclassified Burkholderiales 28216|Betaproteobacteria C NAD(P)H quinone oxidoreductase, PIG3 family qor1 - 1.6.5.5 ko:K00344 - - - - ko00000,ko01000 - - - ADH_N,ADH_zinc_N k59_1038418_1 203122.Sde_0976 1.21e-93 276.0 COG0098@1|root,COG0098@2|Bacteria,1MUS4@1224|Proteobacteria,1RNEV@1236|Gammaproteobacteria,464RY@72275|Alteromonadaceae 1236|Gammaproteobacteria J Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body rpsE GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990145,GO:1990904 - ko:K02988 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S5,Ribosomal_S5_C k59_1038418_2 926554.KI912637_gene3241 2.01e-07 49.7 COG1841@1|root,COG1841@2|Bacteria 2|Bacteria J maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) rpmD GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02907 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L30 k59_1038418_3 15368.BRADI3G20440.1 3.34e-05 45.8 COG0200@1|root,KOG0846@2759|Eukaryota,37QWE@33090|Viridiplantae,3GCAP@35493|Streptophyta,3KNZC@4447|Liliopsida,3IAU0@38820|Poales 35493|Streptophyta J Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A - - - ko:K02876 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L27A k59_415527_1 436308.Nmar_1574 1.45e-50 162.0 arCOG08684@1|root,arCOG08684@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_415527_3 436308.Nmar_1575 5.06e-38 128.0 arCOG08720@1|root,arCOG08720@2157|Archaea 2157|Archaea S Domain of unknown function (DUF2024) - - - - - - - - - - - - DUF2024 k59_1262618_1 316407.85674689 5.66e-29 103.0 2E3SS@1|root,32YQ9@2|Bacteria,1NAY0@1224|Proteobacteria,1SFBJ@1236|Gammaproteobacteria,3XQ2B@561|Escherichia 1236|Gammaproteobacteria S Lysis protein S homolog from lambdoid prophage essD GO:0001906,GO:0001907,GO:0008150,GO:0016032,GO:0019048,GO:0019058,GO:0019076,GO:0031640,GO:0035821,GO:0035890,GO:0035891,GO:0039633,GO:0040011,GO:0044003,GO:0044004,GO:0044364,GO:0044403,GO:0044419,GO:0044659,GO:0044661,GO:0051701,GO:0051704,GO:0051817,GO:0051818,GO:0051883,GO:0052126,GO:0052192 - - - - - - - - - - Phage_holin_2_1 k59_979595_1 1120953.AUBH01000007_gene1757 1.16e-61 207.0 COG3808@1|root,COG3808@2|Bacteria,1MUQ3@1224|Proteobacteria,1RN4K@1236|Gammaproteobacteria,469CU@72275|Alteromonadaceae 1236|Gammaproteobacteria C Inorganic H+ pyrophosphatase hppA - 3.6.1.1 ko:K15987 ko00190,map00190 - - - ko00000,ko00001,ko01000 3.A.10.1 - - H_PPase k59_190151_1 1088721.NSU_2898 4.78e-53 174.0 COG2825@1|root,COG2825@2|Bacteria,1NFPH@1224|Proteobacteria,2U9NJ@28211|Alphaproteobacteria,2KDJR@204457|Sphingomonadales 204457|Sphingomonadales M Outer membrane protein (OmpH-like) - - - - - - - - - - - - OmpH k59_190151_2 1096930.L284_19450 1.35e-57 181.0 COG0764@1|root,COG0764@2|Bacteria,1RH2T@1224|Proteobacteria,2U7G4@28211|Alphaproteobacteria,2K4JA@204457|Sphingomonadales 204457|Sphingomonadales I Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs fabZ - 4.2.1.59 ko:K02372 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04428,R04535,R04537,R04544,R04568,R04954,R04965,R07764,R10117,R10121 RC00831,RC01095 ko00000,ko00001,ko00002,ko01000,ko01004 - - - FabA k59_1659200_1 1125863.JAFN01000001_gene1004 1.21e-82 255.0 COG0436@1|root,COG0436@2|Bacteria,1MWS8@1224|Proteobacteria,42MEF@68525|delta/epsilon subdivisions,2WJ4D@28221|Deltaproteobacteria 28221|Deltaproteobacteria E PFAM Aminotransferase class I and II yfdZ - 2.6.1.83 ko:K10206,ko:K14261 ko00300,ko01100,ko01110,ko01130,ko01230,map00300,map01100,map01110,map01130,map01230 M00527 R07613 RC00006,RC01847 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 k59_1602324_1 1042376.AFPK01000013_gene26 1.71e-55 190.0 COG1807@1|root,COG1807@2|Bacteria,4NE7V@976|Bacteroidetes,1HXX6@117743|Flavobacteriia 976|Bacteroidetes M 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family - - 2.4.2.43 ko:K07264 ko01503,map01503 M00721 R09773,R09774,R09781 RC00005 ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - - - PMT,PMT_2 k59_77973_1 926569.ANT_20730 2.96e-67 226.0 COG0249@1|root,COG0249@2|Bacteria,2G5IU@200795|Chloroflexi 200795|Chloroflexi L that it carries out the mismatch recognition step. This protein has a weak ATPase activity mutS GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - ko:K03555 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V k59_585161_1 396588.Tgr7_1157 1.27e-116 362.0 COG2844@1|root,COG2844@2|Bacteria,1MV54@1224|Proteobacteria,1RN5T@1236|Gammaproteobacteria,1WWDB@135613|Chromatiales 135613|Chromatiales O Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen glnD - 2.7.7.59 ko:K00990 ko02020,map02020 - - - ko00000,ko00001,ko01000 - - - ACT,DUF294,GlnD_UR_UTase,HD,NTP_transf_2 k59_1715107_1 1122137.AQXF01000007_gene3483 1.71e-67 222.0 COG2373@1|root,COG2373@2|Bacteria,1QV7E@1224|Proteobacteria 1224|Proteobacteria V TIGRFAM Outer membrane protein - - - ko:K13735,ko:K20276 ko02024,ko05100,map02024,map05100 - - - ko00000,ko00001 - - - Calx-beta,SWM_repeat,SdrD_B k59_303561_1 1254432.SCE1572_50740 3.01e-37 143.0 COG1948@1|root,COG3170@1|root,COG3170@2|Bacteria,COG4880@2|Bacteria,1PQKR@1224|Proteobacteria,438JJ@68525|delta/epsilon subdivisions,2X3U8@28221|Deltaproteobacteria,2YX4D@29|Myxococcales 28221|Deltaproteobacteria L Beta propeller domain - - - - - - - - - - - - Beta_propel k59_811537_1 565045.NOR51B_312 5.42e-40 149.0 COG0568@1|root,COG0568@2|Bacteria,1MVNJ@1224|Proteobacteria,1RMQI@1236|Gammaproteobacteria,1J4NF@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth rpoD GO:0000988,GO:0000990,GO:0003674,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006352,GO:0006355,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0016987,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031326,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043254,GO:0044087,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901576,GO:1903506,GO:2000112,GO:2000142,GO:2001141 - ko:K03086 - - - - ko00000,ko03021 - - - Sigma70_ner,Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4 k59_1489932_1 436308.Nmar_0003 2.71e-31 115.0 arCOG01995@1|root,arCOG01995@2157|Archaea,41T3M@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - SpoIIM k59_133538_1 1173020.Cha6605_3385 2.52e-09 58.5 COG0527@1|root,COG0527@2|Bacteria,1G095@1117|Cyanobacteria 1117|Cyanobacteria E aspartate kinase, monofunctional class lysC - 2.7.2.4 ko:K00928 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00017,M00018,M00033,M00525,M00526,M00527 R00480 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - iJN678.lysC AA_kinase,ACT,ACT_7 k59_133538_2 1287475.HMPREF1650_08790 3.45e-105 318.0 COG0136@1|root,COG0136@2|Bacteria,2GJJ8@201174|Actinobacteria,22KPD@1653|Corynebacteriaceae 201174|Actinobacteria E Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate asd GO:0003674,GO:0003824,GO:0004073,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016020,GO:0016053,GO:0016491,GO:0016620,GO:0016903,GO:0019752,GO:0019877,GO:0030312,GO:0040007,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046451,GO:0055114,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.2.1.11 ko:K00133 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00017,M00018,M00033,M00525,M00526,M00527 R02291 RC00684 ko00000,ko00001,ko00002,ko01000 - - iNJ661.Rv3708c Semialdhyde_dh,Semialdhyde_dhC k59_868751_1 1127673.GLIP_0706 2.36e-10 63.2 COG0463@1|root,COG0463@2|Bacteria,1QHN1@1224|Proteobacteria,1S89C@1236|Gammaproteobacteria,46AK9@72275|Alteromonadaceae 1236|Gammaproteobacteria M Glycosyl transferase family 2 - - - - - - - - - - - - Glyco_tranf_2_4 k59_868751_2 1122137.AQXF01000001_gene3169 2.07e-98 295.0 COG2050@1|root,COG2050@2|Bacteria,1QVFN@1224|Proteobacteria,2U7M3@28211|Alphaproteobacteria 28211|Alphaproteobacteria Q Thioesterase-like superfamily - - - - - - - - - - - - 4HBT_3 k59_868751_3 1122137.AQXF01000001_gene3170 1.36e-118 342.0 COG0349@1|root,COG0349@2|Bacteria,1MWFD@1224|Proteobacteria,2TQXS@28211|Alphaproteobacteria 28211|Alphaproteobacteria L 3-5 exonuclease rnd1 - 3.1.13.5 ko:K03684 - - - - ko00000,ko01000,ko03016 - - - DNA_pol_A_exo1 k59_303567_1 316407.1651288 7.52e-107 326.0 COG1263@1|root,COG1264@1|root,COG2190@1|root,COG1263@2|Bacteria,COG1264@2|Bacteria,COG2190@2|Bacteria,1MY1V@1224|Proteobacteria,1RMYZ@1236|Gammaproteobacteria,3XM9K@561|Escherichia 1236|Gammaproteobacteria G PTS system, N-acetylglucosamine-specific nagE GO:0003674,GO:0003824,GO:0005215,GO:0006810,GO:0006950,GO:0006974,GO:0008150,GO:0008643,GO:0009401,GO:0009987,GO:0015144,GO:0015764,GO:0016740,GO:0016772,GO:0016773,GO:0022804,GO:0022857,GO:0033554,GO:0034219,GO:0050896,GO:0051179,GO:0051234,GO:0051716,GO:0055085,GO:0071702,GO:0090563,GO:0090586,GO:1901264 2.7.1.193 ko:K02802,ko:K02803,ko:K02804 ko00520,ko02060,map00520,map02060 M00267 R05199 RC00017,RC03206 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.1.1.15,4.A.1.1.2,4.A.1.1.5,4.A.1.1.7 - iECP_1309.ECP_0691 PTS_EIIA_1,PTS_EIIB,PTS_EIIC k59_133542_1 247639.MGP2080_01861 8.14e-31 122.0 COG4206@1|root,COG4206@2|Bacteria,1MUZG@1224|Proteobacteria,1RP7I@1236|Gammaproteobacteria,1J4FA@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H COG1629 Outer membrane receptor proteins, mostly Fe transport - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_20619_1 1178825.ALIH01000008_gene777 1.84e-98 294.0 COG0191@1|root,COG0191@2|Bacteria,4NF5C@976|Bacteroidetes,1HXRN@117743|Flavobacteriia 976|Bacteroidetes G fructose-bisphosphate aldolase fbaA - 4.1.2.13 ko:K01624 ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00003,M00165,M00167,M00344,M00345 R01068,R01070,R01829,R02568 RC00438,RC00439,RC00603,RC00604 ko00000,ko00001,ko00002,ko01000 - - - F_bP_aldolase k59_20619_2 504487.JCM19302_1885 4.13e-139 397.0 COG0777@1|root,COG0777@2|Bacteria,4NFMH@976|Bacteroidetes,1HXQR@117743|Flavobacteriia 976|Bacteroidetes I Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA accD - 2.1.3.15,6.4.1.2 ko:K01963 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04386 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 - - - Carboxyl_trans k59_1659214_1 1173023.KE650771_gene4619 1.23e-84 271.0 COG5421@1|root,COG5421@2|Bacteria,1G3YW@1117|Cyanobacteria 1117|Cyanobacteria L Transposase - - - - - - - - - - - - DDE_Tnp_1 k59_924127_1 1122137.AQXF01000003_gene1998 2.21e-82 251.0 COG2084@1|root,COG2084@2|Bacteria,1RA7F@1224|Proteobacteria,2UVAZ@28211|Alphaproteobacteria 28211|Alphaproteobacteria I Belongs to the 3-hydroxyisobutyrate dehydrogenase family mmsB - 1.1.1.31 ko:K00020 ko00280,ko01100,map00280,map01100 - R05066 RC00099 ko00000,ko00001,ko01000 - - - NAD_binding_11,NAD_binding_2 k59_924127_2 1122137.AQXF01000003_gene1999 7.78e-84 256.0 COG2197@1|root,COG2197@2|Bacteria 2|Bacteria K response regulator - - - - - - - - - - - - AAA_16,GerE,Response_reg k59_246106_1 1122137.AQXF01000006_gene744 1.1e-85 265.0 COG0665@1|root,COG0665@2|Bacteria,1MVGP@1224|Proteobacteria,2TRX9@28211|Alphaproteobacteria 28211|Alphaproteobacteria E oxidoreductase - - - ko:K09471 ko00330,ko01100,map00330,map01100 M00136 R07415 RC00062 ko00000,ko00001,ko00002,ko01000 - - - DAO k59_924128_1 1370125.AUWT01000054_gene3595 2.83e-43 155.0 COG2124@1|root,COG2124@2|Bacteria,2GNZS@201174|Actinobacteria,234XZ@1762|Mycobacteriaceae 201174|Actinobacteria Q cytochrome P450 - - - - - - - - - - - - p450 k59_868763_1 1504672.669786985 2.35e-41 138.0 COG4274@1|root,COG4274@2|Bacteria,1MZVV@1224|Proteobacteria,2VUPM@28216|Betaproteobacteria 28216|Betaproteobacteria S PFAM GYD family protein - - - - - - - - - - - - GYD k59_471975_1 1033802.SSPSH_002018 6.71e-72 231.0 COG0146@1|root,COG0146@2|Bacteria,1QU46@1224|Proteobacteria,1T2DW@1236|Gammaproteobacteria 1236|Gammaproteobacteria EQ COG0146 N-methylhydantoinase B acetone carboxylase, alpha subunit hyuB - 3.5.2.14 ko:K01474 ko00330,ko01100,map00330,map01100 - R03187 RC00632 ko00000,ko00001,ko01000 - - - Hydantoinase_B k59_20631_1 697282.Mettu_3700 4.84e-62 214.0 COG1020@1|root,COG3321@1|root,COG1020@2|Bacteria,COG3321@2|Bacteria,1QK4F@1224|Proteobacteria,1RPAG@1236|Gammaproteobacteria 1236|Gammaproteobacteria Q COG1020 Non-ribosomal peptide synthetase modules and related proteins - - - - - - - - - - - - AMP-binding,AMP-binding_C,Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,Methyltransf_12,PP-binding,Thioesterase,ketoacyl-synt k59_1262646_1 1229909.NSED_08040 1.76e-123 374.0 COG0525@1|root,arCOG00808@2157|Archaea,41SBK@651137|Thaumarchaeota 651137|Thaumarchaeota J Anticodon-binding domain of tRNA - - 6.1.1.9 ko:K01873 ko00970,map00970 M00359,M00360 R03665 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,tRNA-synt_1 k59_585189_1 1465751.W8QRJ5_9VIRU 8.51e-71 234.0 4QAPV@10239|Viruses,4QV7H@35237|dsDNA viruses no RNA stage 10239|Viruses S DNA binding - - - - - - - - - - - - - k59_471982_1 118797.XP_007471717.1 3.22e-105 320.0 COG0508@1|root,COG1249@1|root,KOG0559@2759|Eukaryota,KOG1335@2759|Eukaryota,38CSR@33154|Opisthokonta,3BHTK@33208|Metazoa,3CS51@33213|Bilateria,480T0@7711|Chordata,48WVC@7742|Vertebrata,3J5CC@40674|Mammalia,4J55Z@91561|Cetartiodactyla 33208|Metazoa C Dihydrolipoyl dehydrogenase - - - - - - - - - - - - Pyr_redox_2,Pyr_redox_dim k59_585192_1 1121935.AQXX01000139_gene3072 4.62e-182 516.0 COG2873@1|root,COG2873@2|Bacteria,1NQME@1224|Proteobacteria,1T1GA@1236|Gammaproteobacteria,1XIBP@135619|Oceanospirillales 135619|Oceanospirillales E O-acetylhomoserine metY - 2.5.1.49 ko:K01740 ko00270,ko01100,map00270,map01100 - R01287,R04859 RC00020,RC02821,RC02848 ko00000,ko00001,ko01000 - - - Cys_Met_Meta_PP k59_20646_1 1131730.BAVI_07941 2.73e-54 183.0 COG0657@1|root,COG0657@2|Bacteria,1TQHX@1239|Firmicutes,4HB91@91061|Bacilli,1ZB27@1386|Bacillus 91061|Bacilli I COG0657 Esterase lipase - - - ko:K01066 - - - - ko00000,ko01000 - - - Abhydrolase_3 k59_20646_2 1123279.ATUS01000004_gene2837 9.96e-20 82.0 COG1146@1|root,COG1146@2|Bacteria,1RH5I@1224|Proteobacteria,1S5ZK@1236|Gammaproteobacteria,1J6E3@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions fdxA - - ko:K05524 - - - - ko00000 - - - DUF3470,Fer4,Fer4_9 k59_190191_1 1122137.AQXF01000003_gene2277 9.8e-69 229.0 COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,2TR80@28211|Alphaproteobacteria 28211|Alphaproteobacteria P P-type ATPase' - - 3.6.3.4 ko:K01533 - - R00086 RC00002 ko00000,ko01000 3.A.3.5 - - ATPase-cat_bd,E1-E2_ATPase,HMA,Hydrolase k59_1602384_1 1367847.JCM7686_0719 5.67e-15 76.6 COG0062@1|root,COG0063@1|root,COG0062@2|Bacteria,COG0063@2|Bacteria,1MU1Q@1224|Proteobacteria,2TT58@28211|Alphaproteobacteria,2PUMM@265|Paracoccus 28211|Alphaproteobacteria G Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration nnrD - 4.2.1.136,5.1.99.6 ko:K17758,ko:K17759 - - - - ko00000,ko01000 - - - Carb_kinase,YjeF_N k59_471992_3 760192.Halhy_5989 6.16e-16 75.1 COG1515@1|root,COG1515@2|Bacteria,4NQD8@976|Bacteroidetes,1IYMT@117747|Sphingobacteriia 976|Bacteroidetes L COGs COG1515 Deoxyinosine 3'endonuclease (endonuclease V) recD - 3.1.11.5,3.1.21.7 ko:K01144,ko:K05982 - - - - ko00000,ko01000,ko03400 - - - Endonuclease_5 k59_1319890_1 398578.Daci_5580 7.82e-09 56.2 COG3166@1|root,COG3166@2|Bacteria,1RF1S@1224|Proteobacteria,2VN9T@28216|Betaproteobacteria,4AAVZ@80864|Comamonadaceae 28216|Betaproteobacteria NU PFAM Fimbrial assembly family protein pilN - - ko:K02663 - - - - ko00000,ko02035,ko02044 - - - PilN k59_1319890_2 159087.Daro_0210 3.57e-71 226.0 COG4972@1|root,COG4972@2|Bacteria,1MX8P@1224|Proteobacteria,2VH6W@28216|Betaproteobacteria,2KV8N@206389|Rhodocyclales 206389|Rhodocyclales NU Pilus assembly protein pilM - - ko:K02662 - - - - ko00000,ko02035,ko02044 - - - PilM_2 k59_190193_2 710111.FraQA3DRAFT_3330 2.6e-135 398.0 COG0596@1|root,COG0596@2|Bacteria,2GK79@201174|Actinobacteria,4ETYJ@85013|Frankiales 201174|Actinobacteria S epoxide hydrolase - - 3.3.2.9 ko:K01253 ko00980,ko04976,ko05204,map00980,map04976,map05204 - R07013,R07014,R07027,R07071,R07072,R07082,R09410,R09417,R09443 RC01447,RC01728,RC01764,RC02528 ko00000,ko00001,ko01000,ko01002 - - - EHN k59_1376919_1 911045.PSE_3468 1.59e-16 78.6 COG0739@1|root,COG0739@2|Bacteria,1MVTF@1224|Proteobacteria,2TQZE@28211|Alphaproteobacteria 28211|Alphaproteobacteria M COG0739 Membrane proteins related to metalloendopeptidases MA20_30780 - - - - - - - - - - - Peptidase_M23 k59_1376919_2 95619.PM1_0206680 5.41e-61 209.0 COG0653@1|root,COG0653@2|Bacteria,1MUJZ@1224|Proteobacteria,1RM9M@1236|Gammaproteobacteria 1236|Gammaproteobacteria U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane secA GO:0000166,GO:0002790,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006457,GO:0006605,GO:0006810,GO:0006886,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0009306,GO:0009987,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032940,GO:0032991,GO:0033036,GO:0033220,GO:0034613,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042802,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0046903,GO:0046907,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0061077,GO:0065002,GO:0070727,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680 - ko:K03070 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4 - - SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW k59_754451_1 870187.Thini_2000 7.19e-82 249.0 COG0247@1|root,COG0247@2|Bacteria,1RF02@1224|Proteobacteria,1S302@1236|Gammaproteobacteria,462CF@72273|Thiotrichales 72273|Thiotrichales C Protein of unknown function (DUF3501) - - - - - - - - - - - - DUF3501 k59_78036_1 1081640.AGFU01000036_gene3047 1.21e-50 176.0 COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,2TVDE@28211|Alphaproteobacteria,2K1ZN@204457|Sphingomonadales 204457|Sphingomonadales M Outer membrane efflux protein - - - - - - - - - - - - OEP k59_979649_1 1122137.AQXF01000003_gene1927 5.99e-81 258.0 COG2861@1|root,COG2861@2|Bacteria,1N3JP@1224|Proteobacteria,2TUFD@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Protein conserved in bacteria - - - - - - - - - - - - Polysacc_deac_2 k59_1093459_1 1248760.ANFZ01000023_gene146 3.71e-29 117.0 COG0795@1|root,COG0795@2|Bacteria,1MUF2@1224|Proteobacteria,2U55Q@28211|Alphaproteobacteria,2K07C@204457|Sphingomonadales 204457|Sphingomonadales S YjgP YjgQ family - - - ko:K07091 ko02010,map02010 M00320 - - ko00000,ko00001,ko00002,ko02000 1.B.42.1 - - YjgP_YjgQ k59_1093459_2 1122137.AQXF01000005_gene994 7.19e-71 229.0 2EDGC@1|root,337CJ@2|Bacteria,1RE5R@1224|Proteobacteria,2U8YS@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_1771365_1 626887.J057_17665 3.07e-117 379.0 COG3637@1|root,COG4547@1|root,COG4932@1|root,COG3637@2|Bacteria,COG4547@2|Bacteria,COG4932@2|Bacteria,1QUEG@1224|Proteobacteria,1T4AQ@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane - - - - - - - - - - - - Calx-beta k59_698365_1 323848.Nmul_A1119 3.65e-53 180.0 COG0793@1|root,COG0793@2|Bacteria,1MU39@1224|Proteobacteria,2VJ86@28216|Betaproteobacteria,372E5@32003|Nitrosomonadales 28216|Betaproteobacteria M Belongs to the peptidase S41A family ctpA - 3.4.21.102 ko:K03797 - - - - ko00000,ko01000,ko01002 - - - PDZ,PDZ_2,Peptidase_S41 k59_698365_2 1005048.CFU_4065 2.24e-13 69.7 COG4942@1|root,COG4942@2|Bacteria,1MY3E@1224|Proteobacteria,2VIV9@28216|Betaproteobacteria,473EQ@75682|Oxalobacteraceae 28216|Betaproteobacteria D Peptidase family M23 envC - - - - - - - - - - - Peptidase_M23 k59_1319896_1 1232683.ADIMK_1486 1.25e-34 130.0 COG0154@1|root,COG0154@2|Bacteria,1MUVQ@1224|Proteobacteria,1RR5Z@1236|Gammaproteobacteria,465T3@72275|Alteromonadaceae 1236|Gammaproteobacteria J COG0154 Asp-tRNAAsn Glu-tRNAGln amidotransferase A subunit and related amidases atzF - 3.5.1.54 ko:K01457 ko00220,ko00791,ko01100,ko01120,map00220,map00791,map01100,map01120 - R00005 RC02756 ko00000,ko00001,ko01000 - - - Amidase k59_1038510_1 323848.Nmul_A1295 6.42e-108 321.0 COG2801@1|root,COG2801@2|Bacteria,1MVXQ@1224|Proteobacteria,2VQF1@28216|Betaproteobacteria,37275@32003|Nitrosomonadales 28216|Betaproteobacteria L HTH-like domain - - - ko:K07497 - - - - ko00000 - - - HTH_21,rve k59_1715178_1 436308.Nmar_1647 7.51e-30 119.0 arCOG08812@1|root,arCOG08812@2157|Archaea,41T0K@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_924178_1 335284.Pcryo_0641 5.35e-46 154.0 COG3223@1|root,COG3223@2|Bacteria,1PWBR@1224|Proteobacteria,1SES3@1236|Gammaproteobacteria,3NSQJ@468|Moraxellaceae 1236|Gammaproteobacteria S Phosphate-starvation-inducible E - - - - - - - - - - - - PsiE k59_1093467_2 1173264.KI913949_gene3646 8.46e-53 181.0 COG0017@1|root,COG0017@2|Bacteria,1G015@1117|Cyanobacteria,1H7PZ@1150|Oscillatoriales 1117|Cyanobacteria J PFAM tRNA synthetases class II (D, K and N) asnS - 6.1.1.22 ko:K01893 ko00970,map00970 M00359,M00360 R03648 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_2,tRNA_anti-codon k59_1208023_1 158500.BV97_01535 1.33e-07 52.0 COG1282@1|root,COG1282@2|Bacteria,1MUP4@1224|Proteobacteria,2TQN1@28211|Alphaproteobacteria,2K05C@204457|Sphingomonadales 204457|Sphingomonadales C The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane pntB - 1.6.1.2 ko:K00325 ko00760,ko01100,map00760,map01100 - R00112 RC00001 ko00000,ko00001,ko01000 - - - PNTB k59_1208023_2 1088721.NSU_4122 5.9e-34 120.0 297IB@1|root,2ZURJ@2|Bacteria,1NA2F@1224|Proteobacteria,2UH54@28211|Alphaproteobacteria,2K7CH@204457|Sphingomonadales 204457|Sphingomonadales - - - - - - - - - - - - - - - k59_1208023_3 1144305.PMI02_01445 1.81e-47 162.0 COG0232@1|root,COG0232@2|Bacteria,1MVQ2@1224|Proteobacteria,2TRCD@28211|Alphaproteobacteria,2K0JG@204457|Sphingomonadales 204457|Sphingomonadales F dGTPase family. Type 2 subfamily dgt - 3.1.5.1 ko:K01129 ko00230,map00230 - R01856 RC00017 ko00000,ko00001,ko01000 - - - HD,HD_assoc k59_699556_1 710685.MycrhN_6335 1.71e-45 161.0 COG0438@1|root,COG0438@2|Bacteria,2GP58@201174|Actinobacteria,23C8Y@1762|Mycobacteriaceae 201174|Actinobacteria M Sulfotransferase family - - - - - - - - - - - - Sulfotransfer_3 k59_134762_1 237368.SCABRO_00086 2.55e-70 221.0 COG2887@1|root,COG2887@2|Bacteria 2|Bacteria L Belongs to the helicase family. UvrD subfamily - - 3.6.4.12 ko:K10742 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - AAA_24,PDDEXK_1 k59_528608_2 521674.Plim_3498 3.06e-11 63.2 COG0247@1|root,COG0247@2|Bacteria,2IXBR@203682|Planctomycetes 203682|Planctomycetes C Cysteine-rich domain - - - ko:K11473 ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130 - R00475 RC00042 ko00000,ko00001 - - - CCG,Fer4_7,Fer4_8 k59_134768_1 446468.Ndas_4419 9.43e-07 51.6 COG0515@1|root,COG0515@2|Bacteria,2GIV0@201174|Actinobacteria,4EG74@85012|Streptosporangiales 201174|Actinobacteria KLT Protein tyrosine kinase - - - - - - - - - - - - Pkinase k59_191034_1 1144275.COCOR_05413 5.24e-142 422.0 COG2234@1|root,COG2234@2|Bacteria,1MV86@1224|Proteobacteria 1224|Proteobacteria U Peptidase m28 - - - - - - - - - - - - PA,Peptidase_M28 k59_1547464_1 697282.Mettu_2983 2.68e-44 159.0 COG2404@1|root,COG2404@2|Bacteria,1MXEH@1224|Proteobacteria,1SADM@1236|Gammaproteobacteria 1236|Gammaproteobacteria S phosphoesterase DHHA1 - - - - - - - - - - - - DHHA1 k59_1547464_3 1027396.LMOSA_9440 4.24e-16 74.3 2DRJA@1|root,33C0M@2|Bacteria,1VKIR@1239|Firmicutes,4HR8Z@91061|Bacilli,26MXA@186820|Listeriaceae 91061|Bacilli S Domain of Unknown Function with PDB structure (DUF3850) - - - - - - - - - - - - DUF3850 k59_478763_1 1122137.AQXF01000001_gene3397 4.23e-86 262.0 COG0501@1|root,COG0501@2|Bacteria,1MUV4@1224|Proteobacteria,2TS3N@28211|Alphaproteobacteria 28211|Alphaproteobacteria O Belongs to the peptidase M48B family htpX - - ko:K03799 - M00743 - - ko00000,ko00002,ko01000,ko01002 - - - Peptidase_M48 k59_369950_1 1333998.M2A_2835 1.6e-80 252.0 COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2TQR1@28211|Alphaproteobacteria 28211|Alphaproteobacteria C belongs to the aldehyde dehydrogenase family - GO:0001505,GO:0003674,GO:0003824,GO:0004777,GO:0006082,GO:0006520,GO:0006525,GO:0006527,GO:0006576,GO:0006595,GO:0006598,GO:0006807,GO:0008150,GO:0008152,GO:0009013,GO:0009056,GO:0009063,GO:0009064,GO:0009065,GO:0009308,GO:0009310,GO:0009445,GO:0009447,GO:0009448,GO:0009450,GO:0009987,GO:0016054,GO:0016491,GO:0016620,GO:0016903,GO:0019752,GO:0032787,GO:0034641,GO:0042133,GO:0042135,GO:0042402,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0055114,GO:0065007,GO:0065008,GO:0071704,GO:0072329,GO:0097164,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 1.2.1.16,1.2.1.20,1.2.1.24,1.2.1.79 ko:K00135,ko:K08324 ko00250,ko00310,ko00350,ko00650,ko00760,ko01100,ko01120,map00250,map00310,map00350,map00650,map00760,map01100,map01120 M00027 R00713,R00714,R02401 RC00080 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_1047625_1 762376.AXYL_05687 5.5e-60 207.0 COG0542@1|root,COG0542@2|Bacteria,1MVBH@1224|Proteobacteria,2VHSN@28216|Betaproteobacteria,3T655@506|Alcaligenaceae 28216|Betaproteobacteria O COG0542 ATPases with chaperone activity, ATP-binding subunit clpV - - ko:K11907 ko02025,ko03070,map02025,map03070 M00334 - - ko00000,ko00001,ko00002,ko02044 3.A.23.1 - - AAA,AAA_2,ClpB_D2-small,Clp_N k59_930819_1 1429916.X566_11915 1.11e-48 171.0 COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2TR2W@28211|Alphaproteobacteria,3JR7R@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria IQ AMP-binding enzyme C-terminal domain - - 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding,AMP-binding_C k59_878256_1 1040987.AZUY01000026_gene5762 1.57e-09 66.6 COG1020@1|root,COG3319@1|root,COG1020@2|Bacteria,COG3319@2|Bacteria,1MWZM@1224|Proteobacteria,2U0GA@28211|Alphaproteobacteria 28211|Alphaproteobacteria Q Thioesterase domain - - - - - - - - - - - - Thioesterase k59_594595_2 240015.ACP_2293 1.41e-30 121.0 COG0058@1|root,COG0058@2|Bacteria,3Y65H@57723|Acidobacteria,2JM98@204432|Acidobacteriia 204432|Acidobacteriia G Carbohydrate phosphorylase - - 2.4.1.1 ko:K00688 ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931 - R02111 - ko00000,ko00001,ko01000 - GT35 - Phosphorylase k59_761055_1 1267533.KB906734_gene3974 1.71e-63 206.0 COG2513@1|root,COG2513@2|Bacteria,3Y34U@57723|Acidobacteria 57723|Acidobacteria G Phosphoenolpyruvate phosphomutase - - - - - - - - - - - - PEP_mutase k59_817947_1 1382356.JQMP01000003_gene1647 1.37e-31 122.0 COG1651@1|root,COG1651@2|Bacteria,2G8TG@200795|Chloroflexi,27YB4@189775|Thermomicrobia 189775|Thermomicrobia O DSBA-like thioredoxin domain - - - - - - - - - - - - Thioredoxin_4 k59_30462_1 1121385.AQXW01000004_gene875 9.24e-25 103.0 COG1132@1|root,COG1132@2|Bacteria,2GITR@201174|Actinobacteria,1ZVJS@145357|Dermacoccaceae 201174|Actinobacteria V ABC transporter transmembrane region - - - - - - - - - - - - ABC_membrane,ABC_tran k59_594603_1 1122137.AQXF01000007_gene3514 3.84e-150 432.0 COG0508@1|root,COG0508@2|Bacteria,1MUJD@1224|Proteobacteria,2TS5N@28211|Alphaproteobacteria 28211|Alphaproteobacteria C The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) sucB - 2.3.1.61 ko:K00658 ko00020,ko00310,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00032 R02570,R02571,R08549 RC00004,RC02727,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - 2-oxoacid_dh,Biotin_lipoyl,E3_binding k59_594603_2 1122137.AQXF01000007_gene3513 1.58e-61 201.0 COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,2TRN7@28211|Alphaproteobacteria 28211|Alphaproteobacteria C COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes lpdA - 1.8.1.4 ko:K00382 ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00036,M00307,M00532 R00209,R01221,R01698,R03815,R07618,R08549 RC00004,RC00022,RC00583,RC02742,RC02833,RC02834 br01601,ko00000,ko00001,ko00002,ko01000,ko04147 - - - Biotin_lipoyl,Pyr_redox_2,Pyr_redox_dim k59_1499715_1 702113.PP1Y_AT11682 4.8e-182 517.0 COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2TQR1@28211|Alphaproteobacteria,2JZVD@204457|Sphingomonadales 204457|Sphingomonadales C belongs to the aldehyde dehydrogenase family - - 1.2.1.3 ko:K00128 ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130 M00135 R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146 RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_534127_1 395493.BegalDRAFT_2442 6.54e-29 119.0 COG3297@1|root,COG3297@2|Bacteria,1NVVW@1224|Proteobacteria,1S01F@1236|Gammaproteobacteria,462ER@72273|Thiotrichales 72273|Thiotrichales U Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins - - - ko:K02461 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - GspL_C,T2SSL k59_878298_1 316407.85676047 2.83e-124 364.0 COG0439@1|root,COG0439@2|Bacteria,1MU4H@1224|Proteobacteria,1RMNB@1236|Gammaproteobacteria,3XP5G@561|Escherichia 1236|Gammaproteobacteria I first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA accC GO:0003674,GO:0003824,GO:0004075,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0016053,GO:0016874,GO:0016879,GO:0019216,GO:0019217,GO:0019222,GO:0019752,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032787,GO:0042304,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046394,GO:0046890,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051055,GO:0062012,GO:0062014,GO:0065007,GO:0071704,GO:0072330,GO:0080090,GO:1901576 6.3.4.14,6.4.1.2 ko:K01961 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04385 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 - - iSF_1195.SF3294 Biotin_carb_C,Biotin_carb_N,CPSase_L_D2 k59_817968_1 930166.CD58_22615 5.01e-24 107.0 COG2207@1|root,COG2207@2|Bacteria,1R4MG@1224|Proteobacteria,1RQ8P@1236|Gammaproteobacteria 1236|Gammaproteobacteria K AraC family transcriptional regulator - - - - - - - - - - - - Arabinose_bd,HTH_18 k59_197617_1 391589.RGAI101_1235 2.65e-126 389.0 COG0004@1|root,COG0840@1|root,COG0004@2|Bacteria,COG0840@2|Bacteria,1NR9F@1224|Proteobacteria,2TYBM@28211|Alphaproteobacteria,2P46N@2433|Roseobacter 28211|Alphaproteobacteria P Ammonium Transporter Family - - - - - - - - - - - - Ammonium_transp,MCPsignal,SpoIIE k59_30493_1 330214.NIDE0029 1.04e-25 110.0 COG2203@1|root,COG3604@1|root,COG2203@2|Bacteria,COG3604@2|Bacteria 2|Bacteria KT transcription factor binding fhlA GO:0000976,GO:0000984,GO:0001017,GO:0001067,GO:0001150,GO:0001158,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006352,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016043,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0022607,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031334,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0035326,GO:0042802,GO:0043170,GO:0043254,GO:0043565,GO:0043933,GO:0044085,GO:0044087,GO:0044089,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0045893,GO:0045935,GO:0046483,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051128,GO:0051130,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0060255,GO:0065003,GO:0065007,GO:0071704,GO:0071840,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2000142,GO:2000144,GO:2001141 - ko:K02584,ko:K12146,ko:K12266,ko:K15836,ko:K21009 ko02020,ko02025,ko05132,map02020,map02025,map05132 - - - ko00000,ko00001,ko03000 - - - GAF,GAF_2,GAF_3,HTH_8,Sigma54_activat k59_1216229_1 1254432.SCE1572_32845 6.35e-37 137.0 COG0448@1|root,COG0448@2|Bacteria,1MVTC@1224|Proteobacteria,42NGK@68525|delta/epsilon subdivisions,2WM29@28221|Deltaproteobacteria,2YU1M@29|Myxococcales 28221|Deltaproteobacteria H Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans - - 2.7.7.27 ko:K00975 ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026 M00565 R00948 RC00002 ko00000,ko00001,ko00002,ko01000 - - - NTP_transferase k59_1386441_1 1005048.CFU_2131 1.83e-21 89.7 COG0625@1|root,COG0625@2|Bacteria,1RAIN@1224|Proteobacteria,2VKU4@28216|Betaproteobacteria 28216|Betaproteobacteria O Belongs to the GST superfamily - - 2.5.1.18 ko:K00799 ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418 - R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905 RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944 ko00000,ko00001,ko01000,ko02000 1.A.12.2.2,1.A.12.3.2 - - GST_C,GST_C_3,GST_N k59_1386441_2 1231185.BAMP01000029_gene472 5.72e-31 114.0 COG1733@1|root,COG1733@2|Bacteria,1R6HM@1224|Proteobacteria,2U1TS@28211|Alphaproteobacteria,43JPR@69277|Phyllobacteriaceae 28211|Alphaproteobacteria K transcriptional - - - - - - - - - - - - HxlR k59_1047670_1 203122.Sde_2940 1.11e-55 178.0 COG1238@1|root,COG1238@2|Bacteria,1RHUV@1224|Proteobacteria,1S69A@1236|Gammaproteobacteria,46808@72275|Alteromonadaceae 1236|Gammaproteobacteria S membrane yqaA GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - - - - - - - - - - SNARE_assoc k59_30494_1 626887.J057_22410 1.85e-41 139.0 COG0328@1|root,COG0328@2|Bacteria,1RCZ1@1224|Proteobacteria,1S3YC@1236|Gammaproteobacteria,4676A@72275|Alteromonadaceae 1236|Gammaproteobacteria L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids rnhA GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576 3.1.26.4 ko:K03469 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - RNase_H k59_30494_2 595536.ADVE02000001_gene641 5.7e-11 69.3 COG0500@1|root,COG2226@2|Bacteria,1NA7K@1224|Proteobacteria,2TT7T@28211|Alphaproteobacteria,36XZZ@31993|Methylocystaceae 28211|Alphaproteobacteria Q Methyltransferase domain MA20_39625 - - - - - - - - - - - Methyltransf_11 k59_1499745_1 1229909.NSED_06550 3.79e-43 144.0 arCOG08634@1|root,arCOG08634@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_1499745_2 436308.Nmar_1175 6.91e-94 275.0 COG0221@1|root,arCOG01711@2157|Archaea,41T3F@651137|Thaumarchaeota 651137|Thaumarchaeota C Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions ppa - 3.6.1.1 ko:K01507 ko00190,map00190 - - - ko00000,ko00001,ko01000 - - - Pyrophosphatase k59_1326598_1 1415778.JQMM01000001_gene1049 7.51e-106 326.0 COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,1RQUR@1236|Gammaproteobacteria,1J54K@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria F Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen nrdZ - 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - Intein_splicing,LAGLIDADG_3,Ribonuc_red_lgC,Ribonuc_red_lgN k59_1666484_1 227086.JGI_V11_90875 2.37e-41 156.0 COG0345@1|root,KOG3124@2759|Eukaryota 2759|Eukaryota E pyrroline-5-carboxylate reductase activity P5CR - 1.5.1.2 ko:K00286 ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230 M00015 R01248,R01251,R03291,R03293 RC00054,RC00083 ko00000,ko00001,ko00002,ko01000 - - - F420_oxidored,P5CR_dimer k59_817987_1 1232410.KI421418_gene2244 1.9e-44 160.0 COG2982@1|root,COG2982@2|Bacteria,1MUME@1224|Proteobacteria,42M50@68525|delta/epsilon subdivisions,2WIP4@28221|Deltaproteobacteria 28221|Deltaproteobacteria M Domain of Unknown Function (DUF748) - - - - - - - - - - - - DUF748 k59_255302_1 258594.RPA4703 8.02e-13 67.0 COG0673@1|root,COG0673@2|Bacteria,1MXUP@1224|Proteobacteria,2TV6R@28211|Alphaproteobacteria,3JWGS@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S Oxidoreductase family, NAD-binding Rossmann fold ligC - 1.1.1.312 ko:K10219 ko00350,ko00362,ko00627,ko01120,ko01220,map00350,map00362,map00627,map01120,map01220 M00533 R04278,R04279,R04418,R04419 RC00251,RC00254 ko00000,ko00001,ko00002,ko01000 - - - GFO_IDH_MocA,GFO_IDH_MocA_C k59_255302_2 1232410.KI421413_gene484 3.97e-51 165.0 COG2259@1|root,COG2259@2|Bacteria,1N072@1224|Proteobacteria,437CT@68525|delta/epsilon subdivisions,2XA0U@28221|Deltaproteobacteria,43VKC@69541|Desulfuromonadales 28221|Deltaproteobacteria S DoxX - - - ko:K15977 - - - - ko00000 - - - DoxX k59_1611831_1 686340.Metal_3993 2.24e-52 194.0 COG1352@1|root,COG5000@1|root,COG5001@1|root,COG1352@2|Bacteria,COG5000@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1XH10@135618|Methylococcales 135618|Methylococcales NT Methyltransferase, chemotaxis proteins - - 2.1.1.80,3.1.1.61 ko:K13924 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko02022,ko02035 - - - CheR,CheR_N,EAL,GGDEF,PAS_10 k59_1724450_2 1279017.AQYJ01000023_gene3126 4.87e-33 121.0 COG0565@1|root,COG0565@2|Bacteria,1N47Y@1224|Proteobacteria,1RPD3@1236|Gammaproteobacteria,465US@72275|Alteromonadaceae 1236|Gammaproteobacteria J Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA trmJ - 2.1.1.200 ko:K02533,ko:K15396 - - - - ko00000,ko01000,ko03016 - - - SpoU_methylase k59_1439179_2 1415778.JQMM01000001_gene1878 1.1e-18 86.7 COG1752@1|root,COG1752@2|Bacteria,1PDQ2@1224|Proteobacteria,1RMWI@1236|Gammaproteobacteria,1J54S@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S esterase of the alpha-beta hydrolase superfamily - - - ko:K07001 - - - - ko00000 - - - Patatin k59_1047678_1 666681.M301_0003 8.56e-15 79.0 COG0187@1|root,COG0187@2|Bacteria,1MVKT@1224|Proteobacteria,2VI8N@28216|Betaproteobacteria,2KKEJ@206350|Nitrosomonadales 206350|Nitrosomonadales L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrB - 5.99.1.3 ko:K02470 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim k59_878335_1 1117647.M5M_01042 1.15e-78 263.0 COG2902@1|root,COG2902@2|Bacteria,1MXNV@1224|Proteobacteria,1RQVZ@1236|Gammaproteobacteria,1J56W@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E COG2902 NAD-specific glutamate dehydrogenase gdhB - 1.4.1.2 ko:K15371 ko00220,ko00250,ko00430,ko00910,ko01100,map00220,map00250,map00430,map00910,map01100 - R00243 RC00006,RC02799 ko00000,ko00001,ko01000 - - - Bac_GDH,GDH_N k59_1439194_1 1449076.JOOE01000001_gene2630 1.96e-72 229.0 COG0454@1|root,COG0456@2|Bacteria,1PMA3@1224|Proteobacteria,2TUU2@28211|Alphaproteobacteria,2K0BS@204457|Sphingomonadales 204457|Sphingomonadales K acetyltransferase - - - - - - - - - - - - - k59_255325_2 1415779.JOMH01000001_gene3067 7.13e-67 223.0 COG3391@1|root,COG3391@2|Bacteria,1QU01@1224|Proteobacteria 1224|Proteobacteria S Major royal jelly protein - - - - - - - - - - - - MRJP k59_1499780_1 999541.bgla_1g28510 2.17e-38 140.0 COG0415@1|root,COG0415@2|Bacteria,1MV9Y@1224|Proteobacteria,2VITS@28216|Betaproteobacteria,1K2ZA@119060|Burkholderiaceae 28216|Betaproteobacteria L DNA photolyase phrB - 4.1.99.3 ko:K01669 - - - - ko00000,ko01000,ko03400 - - - DNA_photolyase,FAD_binding_7 k59_1499780_2 1346791.M529_07760 2.95e-29 114.0 COG4798@1|root,COG4798@2|Bacteria,1RHGZ@1224|Proteobacteria,2U69N@28211|Alphaproteobacteria,2KDKH@204457|Sphingomonadales 204457|Sphingomonadales S Methyltransferase - - - - - - - - - - - - Methyltransf_25,PCMT k59_30539_1 405948.SACE_5389 2.33e-62 204.0 COG0604@1|root,COG0604@2|Bacteria,2GK7Y@201174|Actinobacteria,4DZMC@85010|Pseudonocardiales 201174|Actinobacteria C Zinc-binding dehydrogenase - - 1.6.5.5 ko:K00344 - - - - ko00000,ko01000 - - - ADH_N,ADH_zinc_N k59_1100845_1 1123502.AQXD01000002_gene431 2.88e-79 255.0 COG0443@1|root,COG0443@2|Bacteria,1MVEN@1224|Proteobacteria,1RMDD@1236|Gammaproteobacteria,1X3SG@135614|Xanthomonadales 135614|Xanthomonadales O Heat shock 70 kDa protein dnaK - - ko:K04043 ko03018,ko04212,ko05152,map03018,map04212,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 1.A.33.1 - - HSP70 k59_478837_1 1187851.A33M_0287 2.47e-73 233.0 COG0859@1|root,COG0859@2|Bacteria,1MYZA@1224|Proteobacteria,2U0ZB@28211|Alphaproteobacteria 28211|Alphaproteobacteria M PFAM glycosyl transferase family 9 waaC - - ko:K02841 ko00540,ko01100,map00540,map01100 M00080 - - ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT9 - Glyco_transf_9 k59_878361_1 1122137.AQXF01000005_gene1210 4.72e-111 335.0 COG1816@1|root,COG1816@2|Bacteria,1R6Q8@1224|Proteobacteria,2U0BN@28211|Alphaproteobacteria 28211|Alphaproteobacteria F PFAM Adenosine AMP deaminase add - 3.5.4.4 ko:K01488 ko00230,ko01100,ko05340,map00230,map01100,map05340 - R01560,R02556 RC00477 ko00000,ko00001,ko01000 - - - A_deaminase k59_1439213_1 870187.Thini_1185 0.000252 41.6 2E0T4@1|root,32WAV@2|Bacteria,1N19Z@1224|Proteobacteria,1SBDA@1236|Gammaproteobacteria,462XP@72273|Thiotrichales 72273|Thiotrichales - - - - - - - - - - - - - - - k59_1439213_2 1123401.JHYQ01000015_gene1406 1.19e-80 245.0 COG0714@1|root,COG0714@2|Bacteria,1MXIW@1224|Proteobacteria,1RN7C@1236|Gammaproteobacteria,45ZUF@72273|Thiotrichales 72273|Thiotrichales S PFAM AAA domain (dynein-related subfamily) - - - ko:K04748 - - R00294 RC02794 ko00000 3.D.4.10 - - AAA_5,CbbQ_C k59_1100850_1 1144307.PMI04_04562 7.6e-159 455.0 COG1804@1|root,COG1804@2|Bacteria,1P68A@1224|Proteobacteria,2TR4B@28211|Alphaproteobacteria,2K371@204457|Sphingomonadales 204457|Sphingomonadales C CoA-transferase family III - - - - - - - - - - - - CoA_transf_3 k59_1439214_1 998674.ATTE01000001_gene2636 3.25e-31 122.0 COG0397@1|root,COG0397@2|Bacteria,1MVK3@1224|Proteobacteria,1RNCS@1236|Gammaproteobacteria,460BH@72273|Thiotrichales 72273|Thiotrichales S Uncharacterized ACR, YdiU/UPF0061 family - - - - - - - - - - - - UPF0061 k59_1270539_2 861299.J421_5719 1.62e-55 192.0 COG1028@1|root,COG3347@1|root,COG1028@2|Bacteria,COG3347@2|Bacteria 2|Bacteria IQ Class II Aldolase and Adducin N-terminal domain - - - - - - - - - - - - Aldolase_II,adh_short,adh_short_C2 k59_1048505_1 1407650.BAUB01000016_gene2370 0.000772 43.9 2E9D1@1|root,333KK@2|Bacteria,1GPAQ@1117|Cyanobacteria,1H2QT@1129|Synechococcus 1117|Cyanobacteria - - - - - - - - - - - - - - - k59_879377_1 1279019.ARQK01000032_gene1144 1.67e-85 270.0 COG0326@1|root,COG0326@2|Bacteria,1MUUE@1224|Proteobacteria,1RNWD@1236|Gammaproteobacteria,1WW6M@135613|Chromatiales 135613|Chromatiales O Molecular chaperone. Has ATPase activity htpG - - ko:K04079 ko04141,ko04151,ko04217,ko04612,ko04621,ko04626,ko04657,ko04659,ko04914,ko04915,ko05200,ko05215,ko05418,map04141,map04151,map04217,map04612,map04621,map04626,map04657,map04659,map04914,map04915,map05200,map05215,map05418 - - - ko00000,ko00001,ko01009,ko03029,ko03051,ko03110,ko04131,ko04147 - - - HATPase_c,HATPase_c_3,HSP90 k59_256350_2 1229909.NSED_02970 5.26e-23 98.2 COG0412@1|root,arCOG10350@1|root,arCOG01659@2157|Archaea,arCOG10350@2157|Archaea,41T1E@651137|Thaumarchaeota 651137|Thaumarchaeota Q Chlorophyllase - - 3.1.1.45 ko:K01061 ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130 - R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222 RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686 ko00000,ko00001,ko01000 - - - DLH k59_1101599_2 926569.ANT_05200 7.66e-64 211.0 COG0664@1|root,COG0664@2|Bacteria,2G63K@200795|Chloroflexi 200795|Chloroflexi T - Catabolite gene activator and regulatory subunit of cAMP-dependent protein - - - - - - - - - - - - - k59_1667256_1 240015.ACP_2896 6.52e-104 330.0 COG0178@1|root,COG0178@2|Bacteria,3Y3G9@57723|Acidobacteria,2JI80@204432|Acidobacteriia 204432|Acidobacteriia L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate - - - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - ABC_tran k59_879379_1 1160137.KB907307_gene2060 1.19e-12 76.3 COG0515@1|root,COG1651@1|root,COG0515@2|Bacteria,COG1651@2|Bacteria,2GNXG@201174|Actinobacteria,4FXUF@85025|Nocardiaceae 201174|Actinobacteria KLT Protein tyrosine kinase - - - - - - - - - - - - Pkinase k59_198681_1 1245469.S58_25950 8.37e-13 71.6 COG4249@1|root,COG4249@2|Bacteria,1R3WZ@1224|Proteobacteria,2TUBK@28211|Alphaproteobacteria,3JSNG@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S Caspase domain - - - - - - - - - - - - Peptidase_C14,SH3_3 k59_879384_1 1089447.RHAA1_09531 9.65e-57 187.0 COG1947@1|root,COG1947@2|Bacteria,1MVU3@1224|Proteobacteria,1RP23@1236|Gammaproteobacteria,1Y7VV@135625|Pasteurellales 135625|Pasteurellales F Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol ispE GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0044237,GO:0050515 2.7.1.148 ko:K00919 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05634 RC00002,RC01439 ko00000,ko00001,ko00002,ko01000 - - - GHMP_kinases_C,GHMP_kinases_N k59_1387581_1 436308.Nmar_0584 1.21e-14 81.3 arCOG08800@1|root,arCOG08800@2157|Archaea 2157|Archaea L metallopeptidase activity - - - - - - - - - - - - CHB_HEX_C_1,Polysacc_deac_1 k59_708932_1 686340.Metal_3856 0.000513 39.7 COG0053@1|root,COG0053@2|Bacteria,1N8A3@1224|Proteobacteria,1SDJW@1236|Gammaproteobacteria,1XFQ9@135618|Methylococcales 135618|Methylococcales P Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family - - - - - - - - - - - - - k59_708932_2 420662.Mpe_A1663 2.24e-19 82.4 COG2608@1|root,COG2608@2|Bacteria,1N95B@1224|Proteobacteria,2VW9C@28216|Betaproteobacteria,1KP0W@119065|unclassified Burkholderiales 28216|Betaproteobacteria P Mercury scavenger that specifically binds to one mercury ion and which passes it to the mercuric reductase (MerA) via the MerT protein merP - - ko:K08364 - - - - ko00000,ko02000 1.A.72.1 - - HMA k59_1777848_2 187272.Mlg_0681 6.01e-102 321.0 COG0272@1|root,COG0272@2|Bacteria,1MV3R@1224|Proteobacteria,1RPAV@1236|Gammaproteobacteria,1WX4B@135613|Chromatiales 135613|Chromatiales L DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA ligA - 6.5.1.2 ko:K01972 ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430 - R00382 RC00005 ko00000,ko00001,ko01000,ko03032,ko03400 - - - BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5 k59_1159421_1 665942.HMPREF1022_01632 2.02e-08 59.3 COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,42NKZ@68525|delta/epsilon subdivisions,2WK44@28221|Deltaproteobacteria,2MG5X@213115|Desulfovibrionales 28221|Deltaproteobacteria M RND efflux system, outer membrane - - - ko:K18139 ko01501,ko02024,map01501,map02024 M00642,M00643,M00647,M00718,M00768,M00822 - - ko00000,ko00001,ko00002,ko01504,ko02000 1.B.17,2.A.6.2 - - OEP k59_1159421_2 1396141.BATP01000060_gene4740 6.59e-14 68.9 COG0745@1|root,COG0745@2|Bacteria,46TFB@74201|Verrucomicrobia,2IUEX@203494|Verrucomicrobiae 203494|Verrucomicrobiae T Transcriptional regulatory protein, C terminal - - - - - - - - - - - - Response_reg,Trans_reg_C k59_595768_1 1120963.KB894507_gene3779 1.8e-37 138.0 COG1570@1|root,COG1570@2|Bacteria,1MUA4@1224|Proteobacteria,1RNAZ@1236|Gammaproteobacteria,2PZSA@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides xseA GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006308,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008855,GO:0009056,GO:0009057,GO:0009318,GO:0009987,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0019439,GO:0032991,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901361,GO:1901575,GO:1902494 3.1.11.6 ko:K03601 ko03430,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - Exonuc_VII_L,tRNA_anti_2 k59_819057_1 582515.KR51_00000330 6.19e-25 108.0 COG1680@1|root,COG1680@2|Bacteria,1G4D0@1117|Cyanobacteria 1117|Cyanobacteria V PFAM beta-lactamase - - - - - - - - - - - - Beta-lactamase k59_371082_2 1122137.AQXF01000002_gene22 2.48e-58 205.0 COG0457@1|root,COG0457@2|Bacteria,1PDUB@1224|Proteobacteria,2TTYN@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Tetratricopeptide repeat - - - - - - - - - - - - TPR_16,TPR_19,TPR_21 k59_1159427_1 1430440.MGMSRv2_3409 5.63e-47 164.0 COG2089@1|root,COG2089@2|Bacteria,1MWG3@1224|Proteobacteria,2TRA6@28211|Alphaproteobacteria,2JRJX@204441|Rhodospirillales 204441|Rhodospirillales M COG2089 Sialic acid synthase - - - - - - - - - - - - NeuB,SAF k59_595772_1 502025.Hoch_5665 8.4e-73 225.0 COG0135@1|root,COG0135@2|Bacteria,1RA5Q@1224|Proteobacteria,42T4S@68525|delta/epsilon subdivisions,2WP9V@28221|Deltaproteobacteria,2Z0RD@29|Myxococcales 28221|Deltaproteobacteria E N-(5'phosphoribosyl)anthranilate (PRA) isomerase - - 5.3.1.24 ko:K01817 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R03509 RC00945 ko00000,ko00001,ko00002,ko01000 - - - PRAI k59_1612619_1 1485544.JQKP01000002_gene1337 1.39e-48 161.0 COG0664@1|root,COG0664@2|Bacteria,1MVGE@1224|Proteobacteria,2VH04@28216|Betaproteobacteria,44VPR@713636|Nitrosomonadales 28216|Betaproteobacteria K helix_turn_helix, cAMP Regulatory protein fnr - - ko:K01420 - - - - ko00000,ko03000 - - - HTH_Crp_2,cNMP_binding k59_819065_1 326427.Cagg_2405 1.67e-19 92.4 COG0643@1|root,COG0745@1|root,COG2198@1|root,COG0643@2|Bacteria,COG0745@2|Bacteria,COG2198@2|Bacteria,2G6G3@200795|Chloroflexi,374SA@32061|Chloroflexia 32061|Chloroflexia T ATP-binding region, ATPase domain protein - - 2.7.13.3 ko:K03407 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 - - - CheW,H-kinase_dim,HATPase_c,Hpt,Response_reg k59_256380_1 436308.Nmar_1002 9.42e-61 189.0 arCOG08684@1|root,arCOG08684@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_604201_1 1123368.AUIS01000004_gene282 2.14e-48 169.0 COG1570@1|root,COG1570@2|Bacteria,1MUA4@1224|Proteobacteria,1RNAZ@1236|Gammaproteobacteria,2NCSP@225057|Acidithiobacillales 225057|Acidithiobacillales L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides xseA - 3.1.11.6 ko:K03601 ko03430,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - Exonuc_VII_L,tRNA_anti_2 k59_604201_2 1116472.MGMO_83c00160 1.09e-47 167.0 COG0516@1|root,COG0517@1|root,COG0516@2|Bacteria,COG0517@2|Bacteria,1MUJM@1224|Proteobacteria,1RMT8@1236|Gammaproteobacteria,1XESH@135618|Methylococcales 135618|Methylococcales F Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth guaB - 1.1.1.205 ko:K00088 ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 M00050 R01130,R08240 RC00143,RC02207 ko00000,ko00001,ko00002,ko01000,ko04147 - - - CBS,IMPDH k59_322618_1 1206741.BAFX01000123_gene650 6.26e-12 68.2 COG1716@1|root,COG3629@1|root,COG1716@2|Bacteria,COG3629@2|Bacteria,2HHCI@201174|Actinobacteria,4FXFV@85025|Nocardiaceae 201174|Actinobacteria T Bacterial transcriptional activator domain - - - - - - - - - - - - BTAD,FHA,Trans_reg_C k59_485851_1 1123257.AUFV01000010_gene3215 1.97e-62 200.0 COG1235@1|root,COG1235@2|Bacteria,1R5N4@1224|Proteobacteria,1S2TG@1236|Gammaproteobacteria,1X67H@135614|Xanthomonadales 135614|Xanthomonadales S Beta-lactamase superfamily domain - - - - - - - - - - - - Lactamase_B_2 k59_1508541_1 153948.NAL212_2186 1.06e-108 326.0 COG0312@1|root,COG0312@2|Bacteria,1MUSK@1224|Proteobacteria,2VHJ9@28216|Betaproteobacteria,372FQ@32003|Nitrosomonadales 28216|Betaproteobacteria S modulator of DNA gyrase tldD - - ko:K03568 - - - - ko00000,ko01002 - - - PmbA_TldD k59_655954_1 1123488.ATUF01000002_gene216 7.52e-27 118.0 COG1196@1|root,COG1196@2|Bacteria,2GK93@201174|Actinobacteria,4D3VV@85005|Actinomycetales 201174|Actinobacteria D Required for chromosome condensation and partitioning smc - - ko:K03529 - - - - ko00000,ko03036 - - - SMC_N,SMC_hinge k59_1395730_1 1123393.KB891327_gene314 1.16e-37 136.0 COG4447@1|root,COG4447@2|Bacteria,1ND1J@1224|Proteobacteria,2VMA5@28216|Betaproteobacteria,1KTCE@119069|Hydrogenophilales 119069|Hydrogenophilales S protein related to plant photosystem II stability assembly factor - - - - - - - - - - - - - k59_1395730_2 643562.Daes_2828 9.12e-15 70.5 COG1254@1|root,COG1254@2|Bacteria,1QUKD@1224|Proteobacteria,42XEI@68525|delta/epsilon subdivisions,2WTAI@28221|Deltaproteobacteria,2MD53@213115|Desulfovibrionales 28221|Deltaproteobacteria C PFAM acylphosphatase - - 3.6.1.7 ko:K01512 ko00620,ko00627,ko01120,map00620,map00627,map01120 - R00317,R01421,R01515 RC00043 ko00000,ko00001,ko01000 - - - Acylphosphatase k59_1395730_3 452637.Oter_3727 3.34e-13 71.6 COG1475@1|root,COG1475@2|Bacteria 2|Bacteria K chromosome segregation - - - ko:K03497 - - - - ko00000,ko03000,ko03036,ko04812 - - - ParBc k59_430227_1 627192.SLG_06480 2.89e-53 176.0 COG4122@1|root,COG4122@2|Bacteria,1N57D@1224|Proteobacteria,2U6NA@28211|Alphaproteobacteria,2KCBH@204457|Sphingomonadales 204457|Sphingomonadales S O-methyltransferase - - - - - - - - - - - - Methyltransf_24 k59_430227_2 1246474.ANBE01000022_gene3922 5.23e-09 58.2 COG0604@1|root,COG0604@2|Bacteria,2GIWC@201174|Actinobacteria,4EHSX@85012|Streptosporangiales 201174|Actinobacteria C Zinc-binding dehydrogenase - - - - - - - - - - - - ADH_N,ADH_zinc_N_2 k59_993747_1 1178825.ALIH01000009_gene1334 4.09e-278 788.0 COG4783@1|root,COG4783@2|Bacteria,4PMBD@976|Bacteroidetes,1IJQH@117743|Flavobacteriia 976|Bacteroidetes S chaperone-mediated protein folding - - - - - - - - - - - - TPR_8 k59_1731543_1 1122137.AQXF01000006_gene741 1.23e-71 229.0 COG0161@1|root,COG0161@2|Bacteria,1MU2N@1224|Proteobacteria,2TQND@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family bioA - 2.6.1.18 ko:K00822 ko00280,ko00410,ko00640,ko01100,map00280,map00410,map00640,map01100 - R00907,R04187 RC00008,RC00062,RC00160 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_3 k59_1731543_2 1281779.H009_10581 1.02e-17 77.8 2EGH4@1|root,33A97@2|Bacteria,1NJ4R@1224|Proteobacteria,2UK5T@28211|Alphaproteobacteria,4BG0M@82115|Rhizobiaceae 28211|Alphaproteobacteria - - - - - - - - - - - - - - PGPGW k59_768305_1 1049564.TevJSym_ag00830 2.21e-40 152.0 COG3850@1|root,COG3850@2|Bacteria,1MWZT@1224|Proteobacteria,1RNPP@1236|Gammaproteobacteria,1J7D0@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T Histidine kinase narX GO:0000155,GO:0000160,GO:0001101,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0004721,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009987,GO:0010035,GO:0010167,GO:0016020,GO:0016301,GO:0016310,GO:0016311,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0016787,GO:0016788,GO:0016791,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0023014,GO:0023052,GO:0033554,GO:0035556,GO:0036211,GO:0042221,GO:0042578,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0046777,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0070887,GO:0071229,GO:0071241,GO:0071249,GO:0071250,GO:0071704,GO:0071944,GO:0080033,GO:0140096,GO:1901564,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902170 2.7.13.3 ko:K07673,ko:K07674 ko02020,map02020 M00471,M00472 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,HisKA_3,PilJ k59_1167433_1 713586.KB900536_gene2601 2.42e-75 236.0 COG0404@1|root,COG0404@2|Bacteria,1MV96@1224|Proteobacteria,1RN2A@1236|Gammaproteobacteria,1WWZ0@135613|Chromatiales 135613|Chromatiales E The glycine cleavage system catalyzes the degradation of glycine gcvT - 2.1.2.10 ko:K00605 ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200 M00532 R01221,R02300,R04125 RC00022,RC00069,RC00183,RC02834 ko00000,ko00001,ko00002,ko01000 - - - GCV_T,GCV_T_C k59_1566114_1 935836.JAEL01000003_gene449 4.37e-240 674.0 COG0422@1|root,COG0422@2|Bacteria,1TNZ3@1239|Firmicutes,4HC0P@91061|Bacilli,1ZBCQ@1386|Bacillus 91061|Bacilli H Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction thiC GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.99.17 ko:K03147 ko00730,ko01100,map00730,map01100 M00127 R03472 RC03251,RC03252 ko00000,ko00001,ko00002,ko01000 - - iYO844.BSU08790 ThiC-associated,ThiC_Rad_SAM k59_655970_1 195105.CN97_16345 9.8e-61 197.0 COG4221@1|root,COG4221@2|Bacteria,1MW86@1224|Proteobacteria,2TSEM@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Belongs to the short-chain dehydrogenases reductases (SDR) family - - - - - - - - - - - - adh_short k59_1108060_2 1160707.AJIK01000019_gene2044 1.83e-08 56.6 COG0778@1|root,COG0778@2|Bacteria,1UYXM@1239|Firmicutes,4HE45@91061|Bacilli,26EC1@186818|Planococcaceae 91061|Bacilli C Nitroreductase family - - - - - - - - - - - - Nitroreductase k59_485878_1 1278307.KB907022_gene830 1.61e-59 207.0 COG0439@1|root,COG0777@1|root,COG0825@1|root,COG0439@2|Bacteria,COG0777@2|Bacteria,COG0825@2|Bacteria,1MU4H@1224|Proteobacteria,1T1GN@1236|Gammaproteobacteria,2QHBJ@267894|Psychromonadaceae 1236|Gammaproteobacteria I Biotin carboxylase C-terminal domain - - - - - - - - - - - - Biotin_carb_C,Biotin_carb_N,CPSase_L_D2,Carboxyl_trans k59_656815_2 1304888.ATWF01000001_gene2616 1.02e-21 89.4 COG1862@1|root,COG1862@2|Bacteria,2GFUW@200930|Deferribacteres 200930|Deferribacteres U Preprotein translocase subunit - - - ko:K03210 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.2 - - YajC k59_265098_1 1088721.NSU_0234 6.49e-83 253.0 COG1619@1|root,COG1619@2|Bacteria,1MWIY@1224|Proteobacteria,2U0U5@28211|Alphaproteobacteria,2K08M@204457|Sphingomonadales 204457|Sphingomonadales V proteins, homologs of microcin C7 resistance protein MccF - - 3.4.17.13 ko:K01297 - - - - ko00000,ko01000,ko01002,ko01011 - - - Peptidase_S66 k59_1168398_2 1179773.BN6_41510 1.32e-24 103.0 COG0318@1|root,COG0318@2|Bacteria,2HSBK@201174|Actinobacteria,4E92R@85010|Pseudonocardiales 201174|Actinobacteria IQ PFAM AMP-dependent synthetase and ligase - - - - - - - - - - - - LuxE k59_1224388_1 857087.Metme_1496 1.94e-22 100.0 COG1729@1|root,COG1729@2|Bacteria,1MUSV@1224|Proteobacteria,1RQWA@1236|Gammaproteobacteria,1XFEG@135618|Methylococcales 135618|Methylococcales D Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division cpoB - - - - - - - - - - - TPR_16,TPR_6,TolA_bind_tri k59_656818_2 1131553.JIBI01000010_gene1365 3.18e-48 164.0 COG1999@1|root,COG1999@2|Bacteria,1N17T@1224|Proteobacteria,2VQFQ@28216|Betaproteobacteria,37308@32003|Nitrosomonadales 28216|Betaproteobacteria S SCO1/SenC - - - ko:K07152 - - - - ko00000,ko03029 - - - SCO1-SenC k59_265108_1 1095750.HMPREF9970_0810 2.75e-12 66.2 COG0443@1|root,COG0443@2|Bacteria,1TP1J@1239|Firmicutes,248QV@186801|Clostridia,1HVI3@1164882|Lachnoanaerobaculum 186801|Clostridia O Heat shock 70 kDa protein dnaK - - ko:K04043 ko03018,ko04212,ko05152,map03018,map04212,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 1.A.33.1 - - HSP70 k59_1277636_1 521096.Tpau_3835 3.84e-48 166.0 COG1960@1|root,COG1960@2|Bacteria,2GM1Q@201174|Actinobacteria 201174|Actinobacteria I acyl-CoA dehydrogenase fadE30 - 1.3.8.7 ko:K00249 ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320 M00013,M00036,M00087 R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754 RC00052,RC00068,RC00076,RC00095,RC00148,RC00246 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_1277636_2 710685.MycrhN_4170 3.6e-11 65.5 COG1960@1|root,COG1960@2|Bacteria,2GKVN@201174|Actinobacteria,2362Z@1762|Mycobacteriaceae 201174|Actinobacteria I acyl-CoA dehydrogenase fadE18 - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_N k59_828024_1 631362.Thi970DRAFT_04697 1.26e-87 286.0 COG1197@1|root,COG1197@2|Bacteria,1MUXG@1224|Proteobacteria,1RNCU@1236|Gammaproteobacteria,1WWJQ@135613|Chromatiales 135613|Chromatiales L Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site mfd - - ko:K03723 ko03420,map03420 - - - ko00000,ko00001,ko01000,ko03400 - - - CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF k59_1619930_1 143224.JQMD01000002_gene3399 6.97e-18 88.6 COG0417@1|root,COG0417@2|Bacteria,4NGEJ@976|Bacteroidetes,1HXZC@117743|Flavobacteriia 976|Bacteroidetes L CarboxypepD_reg-like domain - - - - - - - - - - - - CarbopepD_reg_2 k59_1732488_2 436308.Nmar_1113 1.82e-195 546.0 COG1236@1|root,arCOG00545@2157|Archaea,41SYB@651137|Thaumarchaeota 651137|Thaumarchaeota J exonuclease of the beta-lactamase fold involved in RNA processing - - - ko:K07577 - - - - ko00000 - - - - k59_718181_1 1121912.AUHD01000004_gene2040 1.33e-128 376.0 2BHIY@1|root,32BMD@2|Bacteria,4NNVZ@976|Bacteroidetes,1I10C@117743|Flavobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - TIG k59_718181_2 926559.JoomaDRAFT_0134 1.01e-20 98.2 COG2335@1|root,COG2335@2|Bacteria,4NH49@976|Bacteroidetes,1HXZS@117743|Flavobacteriia 976|Bacteroidetes M Secreted and surface protein containing fasciclin-like repeats - - - - - - - - - - - - Fasciclin k59_888368_1 1144305.PMI02_00889 2.37e-102 306.0 COG0500@1|root,COG2226@2|Bacteria,1R41W@1224|Proteobacteria,2U1RV@28211|Alphaproteobacteria,2K2PR@204457|Sphingomonadales 204457|Sphingomonadales Q Methylase involved in ubiquinone menaquinone biosynthesis - - - - - - - - - - - - Methyltransf_25 k59_1732512_2 1415778.JQMM01000001_gene425 1.52e-48 162.0 COG1075@1|root,COG1075@2|Bacteria,1N2W0@1224|Proteobacteria,1S2JW@1236|Gammaproteobacteria,1J75P@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S acetyltransferases and hydrolases with the alpha beta hydrolase fold - - - - - - - - - - - - Abhydrolase_6,DUF676,Hydrolase_4,PGAP1 k59_1567070_1 272630.MexAM1_META1p1733 4.31e-27 107.0 COG2301@1|root,COG2301@2|Bacteria,1MW0A@1224|Proteobacteria,2TU4H@28211|Alphaproteobacteria,1JSWV@119045|Methylobacteriaceae 28211|Alphaproteobacteria G Belongs to the HpcH HpaI aldolase family - - 4.1.3.24,4.1.3.25 ko:K08691 ko00630,ko00660,ko00680,ko00720,ko01120,ko01200,map00630,map00660,map00680,map00720,map01120,map01200 M00346,M00373,M00376 R00237,R00473,R00934 RC00307,RC00308,RC00311,RC00407,RC00502,RC01205 ko00000,ko00001,ko00002,ko01000 - - - HpcH_HpaI k59_1567070_2 159087.Daro_3364 5.49e-35 130.0 COG0045@1|root,COG0045@2|Bacteria,1MVCE@1224|Proteobacteria,2VHBG@28216|Betaproteobacteria,2KV9X@206389|Rhodocyclales 206389|Rhodocyclales F Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit sucC - 6.2.1.5 ko:K01903 ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374,M00620 R00405,R02404 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000 - - - ATP-grasp_2,Ligase_CoA k59_150318_1 1122137.AQXF01000002_gene323 2.22e-182 515.0 COG0304@1|root,COG0304@2|Bacteria,1MU1X@1224|Proteobacteria,2TR32@28211|Alphaproteobacteria 28211|Alphaproteobacteria I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP fabF GO:0003674,GO:0003824,GO:0004312,GO:0004315,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:0072330,GO:1901576 2.3.1.179 ko:K09458 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119 RC00039,RC02728,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Ketoacyl-synt_C,ketoacyl-synt k59_1109011_2 1229909.NSED_02165 3.29e-80 241.0 arCOG08663@1|root,arCOG08663@2157|Archaea,41SR2@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1168446_1 1121033.AUCF01000028_gene370 1.2e-17 81.3 COG0583@1|root,COG0583@2|Bacteria,1MVA1@1224|Proteobacteria,2TSUS@28211|Alphaproteobacteria,2JPGK@204441|Rhodospirillales 204441|Rhodospirillales K transcriptional regulator - - - ko:K04761 ko02026,map02026 - - - ko00000,ko00001,ko03000 - - - HTH_1,LysR_substrate k59_1168446_2 1122137.AQXF01000001_gene2711 8.83e-100 298.0 COG2064@1|root,COG2064@2|Bacteria,1MWAZ@1224|Proteobacteria,2TSFA@28211|Alphaproteobacteria 28211|Alphaproteobacteria NU type II secretion system protein tadC - - ko:K12511 - - - - ko00000,ko02044 - - - T2SSF k59_541897_1 754477.Q7C_2215 6.22e-114 337.0 COG1290@1|root,COG1290@2|Bacteria,1MV97@1224|Proteobacteria,1RNCP@1236|Gammaproteobacteria,45ZV4@72273|Thiotrichales 72273|Thiotrichales C Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis - - - ko:K00412 ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016 M00151,M00152 - - ko00000,ko00001,ko00002,ko03029 - - - Cytochrom_B_C,Cytochrome_B k59_1674253_1 365528.KB891219_gene1039 1.1e-42 153.0 COG0861@1|root,COG0861@2|Bacteria,2GIWU@201174|Actinobacteria,4ES61@85013|Frankiales 201174|Actinobacteria P PFAM Integral membrane protein TerC - - - ko:K05794 - - - - ko00000 - - - TerC k59_1396472_1 436308.Nmar_1035 3.07e-125 365.0 COG1980@1|root,arCOG04180@2157|Archaea,41S67@651137|Thaumarchaeota 651137|Thaumarchaeota G Catalyzes two subsequent steps in gluconeogenesis the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P) fbp - 3.1.3.11,4.1.2.13 ko:K01622 ko00010,ko00030,ko00051,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map01100,map01110,map01120,map01130,map01200,map01230 M00003 R00762,R01068,R01070,R02568,R04780 RC00017,RC00438,RC00439 ko00000,ko00001,ko00002,ko01000 - - - FBPase_3 k59_1109015_1 292459.STH2616 3.53e-94 309.0 COG2217@1|root,COG2217@2|Bacteria,1TP5S@1239|Firmicutes,247MW@186801|Clostridia 186801|Clostridia P ATPase, P-type (transporting), HAD superfamily, subfamily IC - - 3.6.3.4,3.6.3.54 ko:K01533,ko:K17686 ko01524,ko04016,map01524,map04016 - R00086 RC00002 ko00000,ko00001,ko01000 3.A.3.5 - - E1-E2_ATPase,HMA,Hydrolase k59_1619961_1 1122137.AQXF01000001_gene2718 1.14e-66 216.0 COG1228@1|root,COG1228@2|Bacteria,1MXQX@1224|Proteobacteria,2U1V8@28211|Alphaproteobacteria 28211|Alphaproteobacteria Q overlaps another CDS with the same product name - - - - - - - - - - - - - k59_1732528_1 321846.PS417_07165 2.1e-15 75.5 COG0329@1|root,COG0329@2|Bacteria,1MUCM@1224|Proteobacteria,1RNH9@1236|Gammaproteobacteria 1236|Gammaproteobacteria E Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) dapA GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008840,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0019752,GO:0019877,GO:0042802,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.3.3.7 ko:K01714 ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R10147 RC03062,RC03063 ko00000,ko00001,ko00002,ko01000 - - iECP_1309.ECP_2492,iJN746.PP_1237,iYL1228.KPN_02812 DHDPS k59_1674256_1 555793.WSK_1474 1.06e-110 334.0 COG2234@1|root,COG2234@2|Bacteria,1MV86@1224|Proteobacteria,2TVJ5@28211|Alphaproteobacteria,2K04D@204457|Sphingomonadales 204457|Sphingomonadales S Peptidase, M28 - - - - - - - - - - - - PA,Peptidase_M28 k59_994752_1 1123234.AUKI01000011_gene1031 2.13e-30 121.0 COG3170@1|root,COG3170@2|Bacteria,4NIBX@976|Bacteroidetes,1I0Q0@117743|Flavobacteriia 976|Bacteroidetes NU Belongs to the peptidase M12A family - - - - - - - - - - - - Astacin k59_1732532_1 546264.NEIFLAOT_00958 4.59e-30 119.0 2FACE@1|root,342KV@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_1619968_1 436308.Nmar_0257 3.64e-88 261.0 COG1695@1|root,arCOG00002@2157|Archaea,41SN8@651137|Thaumarchaeota 651137|Thaumarchaeota K Transcriptional regulator PadR-like family - - - - - - - - - - - - PadR k59_1619968_2 1229909.NSED_01190 6.65e-18 82.4 COG1053@1|root,arCOG00571@2157|Archaea,41SAM@651137|Thaumarchaeota 651137|Thaumarchaeota C fumarate reductase flavoprotein - - 1.3.5.1,1.3.5.4 ko:K00239 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134 M00009,M00011,M00149,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,Succ_DH_flav_C k59_718213_1 95619.PM1_0211145 1.87e-106 320.0 COG0161@1|root,COG0161@2|Bacteria,1MU2N@1224|Proteobacteria,1RNW9@1236|Gammaproteobacteria 1236|Gammaproteobacteria E Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family - - - - - - - - - - - - Aminotran_3 k59_1509611_1 1169143.KB911055_gene2513 2.39e-71 225.0 COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,2VJ5H@28216|Betaproteobacteria,1K2CZ@119060|Burkholderiaceae 28216|Betaproteobacteria L transposase IS116 IS110 IS902 family - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_939448_1 329726.AM1_2860 9.26e-47 172.0 COG1716@1|root,COG2203@1|root,COG5001@1|root,COG1716@2|Bacteria,COG2203@2|Bacteria,COG5001@2|Bacteria,1G0SY@1117|Cyanobacteria 1117|Cyanobacteria T signal transduction protein containing a membrane domain an EAL and a GGDEF domain - - - - - - - - - - - - EAL,FHA,GAF,GGDEF,PAS_9 k59_1619969_1 1469245.JFBG01000088_gene1674 3.65e-16 79.7 COG2137@1|root,COG2137@2|Bacteria,1N6P6@1224|Proteobacteria,1SCMF@1236|Gammaproteobacteria,1WYJU@135613|Chromatiales 135613|Chromatiales S Modulates RecA activity recX - - ko:K03565 - - - - ko00000,ko03400 - - - RecX k59_150334_1 702113.PP1Y_AT19464 1.16e-83 253.0 COG3484@1|root,COG3484@2|Bacteria,1N057@1224|Proteobacteria,2U09K@28211|Alphaproteobacteria,2K318@204457|Sphingomonadales 204457|Sphingomonadales O proteasome-type protease - - - ko:K07395 - - - - ko00000 - - - Proteasome k59_1277706_1 565655.ECBG_02992 6.2e-05 45.8 COG0631@1|root,COG0631@2|Bacteria,1V6K5@1239|Firmicutes,4HCDR@91061|Bacilli,4B0N0@81852|Enterococcaceae 91061|Bacilli T Sigma factor PP2C-like phosphatases stp - 3.1.3.16 ko:K20074 - - - - ko00000,ko01000,ko01009 - - - PP2C,PP2C_2 k59_1277706_2 1379270.AUXF01000001_gene2451 4.6e-23 99.4 COG0577@1|root,COG0577@2|Bacteria,1ZTMQ@142182|Gemmatimonadetes 142182|Gemmatimonadetes V MacB-like periplasmic core domain - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_1334471_1 1242864.D187_004776 3e-20 85.9 COG0615@1|root,COG0615@2|Bacteria,1REW3@1224|Proteobacteria,42SGQ@68525|delta/epsilon subdivisions,2WPTP@28221|Deltaproteobacteria 28221|Deltaproteobacteria H Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose rfaE - - - - - - - - - - - CTP_transf_like k59_1334471_2 1499967.BAYZ01000036_gene2402 7.15e-122 379.0 COG1032@1|root,COG1032@2|Bacteria 1499967.BAYZ01000036_gene2402|- C radical SAM domain protein - - - - - - - - - - - - - k59_1334471_3 1123371.ATXH01000009_gene1105 1.02e-15 79.0 COG0682@1|root,COG0682@2|Bacteria,2GGWB@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria M Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins lgt - - ko:K13292 - - - - ko00000,ko01000 - - - LGT k59_1056525_1 316407.85675876 4.93e-178 523.0 COG3250@1|root,COG3250@2|Bacteria,1MVBN@1224|Proteobacteria,1RMER@1236|Gammaproteobacteria,3XN5C@561|Escherichia 1236|Gammaproteobacteria G lactose catabolic process ebgA GO:0000287,GO:0003674,GO:0003824,GO:0004553,GO:0004565,GO:0005488,GO:0005515,GO:0005575,GO:0005975,GO:0005984,GO:0005988,GO:0005990,GO:0008150,GO:0008152,GO:0009056,GO:0009311,GO:0009313,GO:0009341,GO:0009987,GO:0015925,GO:0016052,GO:0016787,GO:0016798,GO:0031420,GO:0032991,GO:0042802,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044262,GO:0044275,GO:0046352,GO:0046872,GO:0071704,GO:1901575,GO:1902494 3.2.1.23 ko:K01190,ko:K12111 ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100 - R01105,R01678,R03355,R04783,R06114 RC00049,RC00452 ko00000,ko00001,ko01000 - - iAF1260.b0344,iB21_1397.B21_00302,iECBD_1354.ECBD_3313,iECB_1328.ECB_00298,iECDH1ME8569_1439.ECDH1ME8569_0331,iECD_1391.ECD_00298,iEcDH1_1363.EcDH1_3262,iJO1366.b0344,iJR904.b0344,iY75_1357.Y75_RS01775 Bgal_small_N,DUF4981,Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N k59_431060_1 1178825.ALIH01000001_gene2328 5.24e-114 340.0 COG1253@1|root,COG1253@2|Bacteria,4NDZ7@976|Bacteroidetes,1HXF3@117743|Flavobacteriia 976|Bacteroidetes S gliding motility-associated protein GldE gldE - - - - - - - - - - - CBS,CorC_HlyC,DUF21 k59_431060_2 983544.Lacal_1223 1.08e-38 133.0 COG0629@1|root,COG0629@2|Bacteria,4NQBK@976|Bacteroidetes,1I27K@117743|Flavobacteriia 976|Bacteroidetes L Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism ssb - - ko:K03111 ko03030,ko03430,ko03440,map03030,map03430,map03440 - - - ko00000,ko00001,ko03029,ko03032,ko03400 - - - SSB k59_1619981_1 316067.Geob_3374 6.54e-87 273.0 COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,42M51@68525|delta/epsilon subdivisions,2WIPP@28221|Deltaproteobacteria,43TCZ@69541|Desulfuromonadales 28221|Deltaproteobacteria NU General secretory system II, protein E domain protein pilB - - ko:K02652 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE,T2SSE_N,cNMP_binding k59_718221_1 316407.85674638 1.58e-181 503.0 COG3209@1|root,COG3209@2|Bacteria 2|Bacteria M self proteolysis ylbH GO:0006950,GO:0007154,GO:0008150,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0010438,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0042594,GO:0050896,GO:0051716,GO:0071496 - - - - - - - - - - RHS,RHS_repeat k59_718221_2 316407.85674637 1.42e-83 246.0 2EV2G@1|root,33NHI@2|Bacteria,1NMGW@1224|Proteobacteria,1SGP1@1236|Gammaproteobacteria 1236|Gammaproteobacteria S NTF2 fold immunity protein ybbC - - - - - - - - - - - Imm-NTF2-2 k59_939456_1 90813.JQMT01000001_gene1800 2.81e-66 215.0 COG3608@1|root,COG3608@2|Bacteria,1MUAA@1224|Proteobacteria,1RNQQ@1236|Gammaproteobacteria,45ZS4@72273|Thiotrichales 72273|Thiotrichales S Succinylglutamate desuccinylase aspartoacylase - - - ko:K06987 - - - - ko00000 - - - AstE_AspA k59_1109035_1 448385.sce6263 6.85e-45 162.0 COG3202@1|root,COG3202@2|Bacteria,1MVP5@1224|Proteobacteria,438CB@68525|delta/epsilon subdivisions,2X3MN@28221|Deltaproteobacteria,2YWIY@29|Myxococcales 28221|Deltaproteobacteria C ATP ADP translocase - - - ko:K03301 - - - - ko00000 2.A.12 - - - k59_1784430_1 1234595.C725_0031 3.59e-53 179.0 COG1612@1|root,COG1612@2|Bacteria,1MVJ4@1224|Proteobacteria,2TR0M@28211|Alphaproteobacteria,4BQ8Z@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria O Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group ctaA - - ko:K02259 ko00190,ko00860,ko01100,ko01110,ko02020,ko04714,map00190,map00860,map01100,map01110,map02020,map04714 M00154 R07412 RC00769 ko00000,ko00001,ko00002,ko03029 3.D.4.4 - - COX15-CtaA k59_1784430_3 1122137.AQXF01000002_gene287 3.33e-53 173.0 COG0600@1|root,COG0600@2|Bacteria,1MVAE@1224|Proteobacteria,2TSP5@28211|Alphaproteobacteria 28211|Alphaproteobacteria P ABC-type nitrate sulfonate bicarbonate transport system permease component MA20_40340 - - ko:K02050 - M00188 - - ko00000,ko00002,ko02000 3.A.1.16,3.A.1.17 - - BPD_transp_1 k59_1732554_1 1429851.X548_04565 1.22e-31 127.0 28JVJ@1|root,2Z9KI@2|Bacteria,1QFFA@1224|Proteobacteria,1TCPH@1236|Gammaproteobacteria,1X9NB@135614|Xanthomonadales 135614|Xanthomonadales - - - - - - - - - - - - - - - k59_1056543_1 1122137.AQXF01000006_gene806 3.89e-111 327.0 COG0189@1|root,COG0189@2|Bacteria,1MV29@1224|Proteobacteria,2U88X@28211|Alphaproteobacteria 28211|Alphaproteobacteria HJ COG0189 Glutathione synthase Ribosomal protein S6 modification enzyme (glutaminyl transferase) - - - - - - - - - - - - GSH-S_ATP k59_48967_2 1122137.AQXF01000001_gene3045 4.18e-43 147.0 28U6D@1|root,2ZGC4@2|Bacteria,1P7GV@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_1344621_2 1028307.EAE_03785 1.72e-48 168.0 COG0641@1|root,COG0641@2|Bacteria,1MX3M@1224|Proteobacteria,1RN4R@1236|Gammaproteobacteria,3X2F9@547|Enterobacter 1236|Gammaproteobacteria C Radical SAM domain protein aslB - - ko:K06871 - - - - ko00000 - - - Fer4_12,Radical_SAM,SPASM k59_275573_1 83406.HDN1F_06900 8.6e-113 340.0 COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,1RPWS@1236|Gammaproteobacteria,1J503@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S COG0488 ATPase components of ABC transporters with duplicated ATPase domains yjjK GO:0003674,GO:0003824,GO:0005488,GO:0006417,GO:0006448,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017148,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0034248,GO:0034249,GO:0043021,GO:0043022,GO:0044877,GO:0045900,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0080090,GO:2000112,GO:2000113 3.6.3.25 ko:K06020 - - - - ko00000,ko01000 - - - ABC_tran,ABC_tran_Xtn k59_275573_2 105559.Nwat_2073 7.66e-133 387.0 COG0123@1|root,COG0123@2|Bacteria,1MU7P@1224|Proteobacteria,1RN8W@1236|Gammaproteobacteria,1WZ4R@135613|Chromatiales 135613|Chromatiales BQ PFAM histone deacetylase superfamily - - - ko:K04768 - - - - ko00000 - - - Hist_deacetyl k59_333223_1 1463895.JODA01000041_gene2979 2.08e-33 125.0 COG1028@1|root,COG1028@2|Bacteria,2IENS@201174|Actinobacteria 201174|Actinobacteria IQ Enoyl-(Acyl carrier protein) reductase - - - - - - - - - - - - adh_short_C2 k59_275583_1 1033802.SSPSH_003548 1.14e-106 347.0 COG0067@1|root,COG0069@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,1MU7B@1224|Proteobacteria,1RN2W@1236|Gammaproteobacteria 1236|Gammaproteobacteria E Glutamate synthase gltB GO:0003674,GO:0003824,GO:0004355,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006541,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0015930,GO:0016053,GO:0016491,GO:0016638,GO:0016639,GO:0019676,GO:0019740,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045181,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.4.1.13,1.4.1.14 ko:K00265 ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 - R00093,R00114,R00248 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - iBWG_1329.BWG_2914,iECDH10B_1368.ECDH10B_3387,iECDH1ME8569_1439.EcDH1_0495,iEcDH1_1363.EcDH1_0495,iPC815.YPO3557 GATase_2,GXGXG,Glu_syn_central,Glu_synthase k59_1119173_2 1178482.BJB45_12875 2.35e-18 85.9 COG0308@1|root,COG0308@2|Bacteria,1MUCI@1224|Proteobacteria,1RMA7@1236|Gammaproteobacteria,1XHS6@135619|Oceanospirillales 135619|Oceanospirillales E aminopeptidase N pepN - 3.4.11.2 ko:K01256 ko00480,ko01100,map00480,map01100 - R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 - - - DUF3458,DUF3458_C,Peptidase_M1 k59_838261_1 1303518.CCALI_02898 5.49e-63 217.0 COG0209@1|root,COG0209@2|Bacteria 2|Bacteria F ribonucleoside-diphosphate reductase activity nrdJ - 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - Ribonuc_red_2_N,Ribonuc_red_lgC k59_217531_1 1121948.AUAC01000002_gene1163 6.05e-33 120.0 COG2030@1|root,COG2030@2|Bacteria,1RHPH@1224|Proteobacteria,2U9GG@28211|Alphaproteobacteria,43Y20@69657|Hyphomonadaceae 28211|Alphaproteobacteria I MaoC like domain nodN - - - - - - - - - - - MaoC_dehydratas k59_1233889_1 1415778.JQMM01000001_gene1424 5.82e-41 144.0 COG3087@1|root,COG3087@2|Bacteria,1MYFG@1224|Proteobacteria,1SD3J@1236|Gammaproteobacteria,1J6IM@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria D COG3087 Cell division protein ftsN - - ko:K03591 - - - - ko00000,ko03036 - - - SPOR k59_1742197_1 743299.Acife_0165 2.02e-39 143.0 COG0286@1|root,COG0286@2|Bacteria,1MW3A@1224|Proteobacteria,1RMRA@1236|Gammaproteobacteria,2NBW9@225057|Acidithiobacillales 225057|Acidithiobacillales L M subunit - - 2.1.1.72 ko:K03427 - - - - ko00000,ko01000,ko02048 - - - HsdM_N,N6_Mtase k59_1742197_2 156889.Mmc1_0131 1.71e-37 135.0 COG3943@1|root,COG3943@2|Bacteria,1MWKW@1224|Proteobacteria,2TU1T@28211|Alphaproteobacteria 28211|Alphaproteobacteria S COG3943 Virulence protein - - - - - - - - - - - - Fic,Virulence_RhuM k59_1577120_1 158500.BV97_01377 1.49e-84 263.0 COG0215@1|root,COG0215@2|Bacteria,1MV8H@1224|Proteobacteria,2TQQ1@28211|Alphaproteobacteria,2K19T@204457|Sphingomonadales 204457|Sphingomonadales J Belongs to the class-I aminoacyl-tRNA synthetase family cysS - 6.1.1.16 ko:K01883 ko00970,map00970 M00359,M00360 R03650 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DALR_2,tRNA-synt_1e k59_1577125_1 1122137.AQXF01000004_gene1535 6.47e-134 391.0 COG0160@1|root,COG0160@2|Bacteria,1MWY6@1224|Proteobacteria,2TUDG@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family gabT - 2.6.1.19,2.6.1.22 ko:K07250 ko00250,ko00280,ko00410,ko00640,ko00650,ko01100,ko01120,map00250,map00280,map00410,map00640,map00650,map01100,map01120 M00027 R00908,R01648,R04188 RC00006,RC00062,RC00160 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 k59_838298_1 391625.PPSIR1_20719 2.16e-46 163.0 COG1408@1|root,COG1408@2|Bacteria,1Q3AY@1224|Proteobacteria,43923@68525|delta/epsilon subdivisions,2X47Q@28221|Deltaproteobacteria,2YYFK@29|Myxococcales 28221|Deltaproteobacteria S Calcineurin-like phosphoesterase superfamily domain - - - - - - - - - - - - Metallophos k59_1742205_1 450851.PHZ_p0163 1.08e-08 65.5 COG4773@1|root,COG4773@2|Bacteria,1QTXJ@1224|Proteobacteria,2U2G4@28211|Alphaproteobacteria,2KGAV@204458|Caulobacterales 204458|Caulobacterales P TonB dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_275614_1 1122137.AQXF01000002_gene467 1.24e-49 172.0 COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2TR2W@28211|Alphaproteobacteria 28211|Alphaproteobacteria IQ COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II fadD - 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding,AMP-binding_C k59_275614_2 1121935.AQXX01000084_gene5377 2.83e-33 126.0 COG1752@1|root,COG1752@2|Bacteria,1MU6Z@1224|Proteobacteria,1RPW6@1236|Gammaproteobacteria,1XIC5@135619|Oceanospirillales 135619|Oceanospirillales S Esterase of the alpha-beta hydrolase superfamily - - - - - - - - - - - - - k59_1178029_1 330214.NIDE3216 3.46e-41 151.0 COG0178@1|root,COG0178@2|Bacteria,3J0ZV@40117|Nitrospirae 40117|Nitrospirae L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate - - - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - - k59_1178029_2 1126627.BAWE01000006_gene6675 7.84e-19 87.8 COG4949@1|root,COG4949@2|Bacteria,1MVI2@1224|Proteobacteria,2TSQJ@28211|Alphaproteobacteria,3JQRM@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S Protein of unknown function (DUF3422) - - - - - - - - - - - - DUF3422 k59_1119203_1 555793.WSK_2661 9.95e-42 148.0 COG0564@1|root,COG0564@2|Bacteria,1MVDX@1224|Proteobacteria,2TTQC@28211|Alphaproteobacteria,2K1YR@204457|Sphingomonadales 204457|Sphingomonadales J Responsible for synthesis of pseudouridine from uracil - - 5.4.99.24 ko:K06179 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2 k59_1119203_2 702113.PP1Y_AT18968 2.76e-45 149.0 COG0239@1|root,COG0239@2|Bacteria,1MZNH@1224|Proteobacteria,2UBUP@28211|Alphaproteobacteria,2K5ZR@204457|Sphingomonadales 204457|Sphingomonadales D Important for reducing fluoride concentration in the cell, thus reducing its toxicity crcB - - ko:K06199 - - - - ko00000,ko02000 1.A.43.1,1.A.43.2,1.A.43.3 - - CRCB k59_1629885_1 349521.HCH_05964 7.13e-106 320.0 COG0493@1|root,COG0493@2|Bacteria,1MU2H@1224|Proteobacteria,1RMY7@1236|Gammaproteobacteria,1XIGF@135619|Oceanospirillales 135619|Oceanospirillales E glutamate synthase gltD - 1.4.1.13,1.4.1.14 ko:K00266 ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 - R00093,R00114,R00248 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - Fer4_20,Pyr_redox_2 k59_1794619_1 1123242.JH636437_gene5985 6.21e-43 148.0 2E01F@1|root,32VQP@2|Bacteria,2J36H@203682|Planctomycetes 203682|Planctomycetes S Chalcone isomerase-like - - - - - - - - - - - - Chalcone_3 k59_898705_1 1094556.MCY_00873 1.58e-19 87.4 COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,2TQK9@28211|Alphaproteobacteria,48TG9@772|Bartonellaceae 28211|Alphaproteobacteria L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate uvrA - - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - ABC_tran k59_898705_2 436308.Nmar_1103 7.63e-101 306.0 COG0322@1|root,arCOG04753@2157|Archaea,41SX9@651137|Thaumarchaeota 651137|Thaumarchaeota L TIGRFAM excinuclease ABC, C subunit - - - ko:K03703 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - GIY-YIG,UVR,UvrC_HhH_N k59_615405_1 1149133.ppKF707_0925 2.03e-32 131.0 COG0642@1|root,COG2205@2|Bacteria,1QTVU@1224|Proteobacteria,1RPFY@1236|Gammaproteobacteria,1YEV2@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria T His Kinase A (phosphoacceptor) domain phoQ GO:0000155,GO:0000160,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0004721,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006464,GO:0006468,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0010350,GO:0016020,GO:0016021,GO:0016301,GO:0016310,GO:0016311,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0016787,GO:0016788,GO:0016791,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0023014,GO:0023052,GO:0031224,GO:0031226,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0035556,GO:0036211,GO:0042578,GO:0042594,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0046777,GO:0046872,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0071496,GO:0071704,GO:0071944,GO:0140096,GO:1901564 2.7.13.3 ko:K07637 ko01503,ko02020,map01503,map02020 M00444,M00709,M00721,M00723,M00724,M00744 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko01504,ko02022 - - - HATPase_c,HisKA,PhoQ_Sensor k59_275630_1 319795.Dgeo_2328 7.78e-91 283.0 COG0114@1|root,COG0114@2|Bacteria,1WJ9Q@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus C Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate fumC GO:0003674,GO:0003824,GO:0004333,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006106,GO:0006108,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017144,GO:0019752,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0055114,GO:0071704,GO:0072350 4.2.1.2 ko:K01679 ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04934,ko05200,ko05211,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200,map04934,map05200,map05211 M00009,M00011,M00173,M00376 R01082 RC00443 ko00000,ko00001,ko00002,ko01000 - - - FumaraseC_C,Lyase_1 k59_778896_1 472759.Nhal_3534 4.56e-82 262.0 COG0366@1|root,COG0366@2|Bacteria,1MVKX@1224|Proteobacteria,1RMXP@1236|Gammaproteobacteria,1WXKA@135613|Chromatiales 135613|Chromatiales G PFAM Alpha amylase, catalytic - - 2.4.1.4,3.2.1.1,5.4.99.16 ko:K05341,ko:K05343 ko00500,ko01100,map00500,map01100 - R01557,R01823,R02108,R02112,R11262 RC00028,RC01816 ko00000,ko00001,ko01000 - GH13 - Alpha-amylase,Malt_amylase_C k59_1629891_1 1123270.ATUR01000006_gene168 7.31e-104 323.0 COG1629@1|root,COG4771@2|Bacteria,1R3VE@1224|Proteobacteria,2UNZN@28211|Alphaproteobacteria,2KEC9@204457|Sphingomonadales 204457|Sphingomonadales P TonB dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_441283_1 1123228.AUIH01000121_gene3493 1.52e-68 224.0 COG3436@1|root,COG3436@2|Bacteria,1MYAC@1224|Proteobacteria,1T2KH@1236|Gammaproteobacteria,1XIK6@135619|Oceanospirillales 135619|Oceanospirillales L Transposase IS66 family - - - - - - - - - - - - DDE_Tnp_IS66,DDE_Tnp_IS66_C,LZ_Tnp_IS66 k59_333293_1 2340.JV46_14790 2.33e-150 432.0 COG0332@1|root,COG0332@2|Bacteria,1MU9N@1224|Proteobacteria,1RNIR@1236|Gammaproteobacteria,1J5D9@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids fabH GO:0003674,GO:0003824,GO:0004312,GO:0004315,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0032787,GO:0033818,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0072330,GO:1901576 2.3.1.180 ko:K00648 ko00061,ko01100,ko01212,map00061,map01100,map01212 M00082,M00083 R10707 RC00004,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - iAF1260.b1091,iAPECO1_1312.APECO1_172,iBWG_1329.BWG_0939,iE2348C_1286.E2348C_1183,iEC55989_1330.EC55989_1203,iECABU_c1320.ECABU_c13040,iECDH10B_1368.ECDH10B_1163,iECDH1ME8569_1439.ECDH1ME8569_1026,iECED1_1282.ECED1_1234,iECH74115_1262.ECH74115_1470,iECIAI39_1322.ECIAI39_2070,iECO103_1326.ECO103_1136,iECO111_1330.ECO111_1368,iECO26_1355.ECO26_1424,iECOK1_1307.ECOK1_1198,iECP_1309.ECP_1083,iECS88_1305.ECS88_1105,iECSP_1301.ECSP_1392,iECW_1372.ECW_m1199,iECs_1301.ECs1469,iEKO11_1354.EKO11_2743,iETEC_1333.ETEC_1156,iEcDH1_1363.EcDH1_2556,iEcE24377_1341.EcE24377A_1212,iEcSMS35_1347.EcSMS35_2036,iG2583_1286.G2583_1351,iJO1366.b1091,iJR904.b1091,iLF82_1304.LF82_0609,iNRG857_1313.NRG857_05260,iSSON_1240.SSON_1111,iSbBS512_1146.SbBS512_E2233,iUMN146_1321.UM146_11870,iUMNK88_1353.UMNK88_1361,iUTI89_1310.UTI89_C1216,iWFL_1372.ECW_m1199,iY75_1357.Y75_RS05700,iZ_1308.Z1730,ic_1306.c1360 ACP_syn_III,ACP_syn_III_C k59_1794625_1 745014.OMB55_00019630 4.37e-44 155.0 COG2374@1|root,COG2374@2|Bacteria,1N5TK@1224|Proteobacteria 1224|Proteobacteria S Endonuclease/Exonuclease/phosphatase family - - - - - - - - - - - - Exo_endo_phos k59_106013_2 1121403.AUCV01000014_gene4561 1.19e-97 311.0 COG0768@1|root,COG0768@2|Bacteria,1MV8C@1224|Proteobacteria,42M1S@68525|delta/epsilon subdivisions,2WJ02@28221|Deltaproteobacteria,2MHV4@213118|Desulfobacterales 28221|Deltaproteobacteria M Penicillin-binding Protein dimerisation domain mrdA - 3.4.16.4 ko:K05515 ko00550,ko01501,map00550,map01501 - - - ko00000,ko00001,ko01000,ko01011 - - iAF987.Gmet_0928 PBP_dimer,Transpeptidase k59_949495_2 1229909.NSED_09100 7.97e-34 118.0 arCOG03681@1|root,arCOG03681@2157|Archaea,41T6V@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1066388_1 685778.AORL01000021_gene958 8.84e-79 254.0 COG1505@1|root,COG1505@2|Bacteria,1NZ7N@1224|Proteobacteria,2TTAX@28211|Alphaproteobacteria,2KDD3@204457|Sphingomonadales 204457|Sphingomonadales E COG1505 Serine proteases of the peptidase family S9A - - 3.4.21.26 ko:K01322 ko04614,map04614 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_S9,Peptidase_S9_N k59_217602_1 1122137.AQXF01000006_gene754 4.12e-120 347.0 COG1802@1|root,COG1802@2|Bacteria,1MVXM@1224|Proteobacteria,2TT9E@28211|Alphaproteobacteria 28211|Alphaproteobacteria K Transcriptional regulator GntR family - - - - - - - - - - - - FCD,GntR k59_1685143_1 794903.OPIT5_11255 1.66e-41 152.0 COG0012@1|root,COG0012@2|Bacteria,46UY8@74201|Verrucomicrobia 74201|Verrucomicrobia J GTP binding - - - - - - - - - - - - - k59_50087_1 643648.Slip_1535 3.6e-16 83.2 COG0728@1|root,COG0728@2|Bacteria,1TPFI@1239|Firmicutes,247N3@186801|Clostridia,42JWT@68298|Syntrophomonadaceae 186801|Clostridia S Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane murJ - - ko:K03980 - - - - ko00000,ko01011,ko02000 2.A.66.4 - - MVIN k59_441318_1 279238.Saro_3791 1.12e-122 356.0 COG0190@1|root,COG0190@2|Bacteria,1MWU4@1224|Proteobacteria,2TRZZ@28211|Alphaproteobacteria,2JZX3@204457|Sphingomonadales 204457|Sphingomonadales F Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate - - 1.5.1.5,3.5.4.9 ko:K01491 ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200 M00140,M00377 R01220,R01655 RC00202,RC00578 ko00000,ko00001,ko00002,ko01000 - - - THF_DHG_CYH,THF_DHG_CYH_C k59_333330_1 667632.KB890198_gene1256 7.6e-17 77.0 COG3657@1|root,COG3657@2|Bacteria,1N74C@1224|Proteobacteria,2VSVC@28216|Betaproteobacteria,1K8N7@119060|Burkholderiaceae 28216|Betaproteobacteria S addiction module killer protein - - - - - - - - - - - - Gp49 k59_333330_2 195250.CM001776_gene493 8.93e-21 85.9 COG3636@1|root,COG3636@2|Bacteria,1GP5B@1117|Cyanobacteria,1H2AT@1129|Synechococcus 1117|Cyanobacteria - - - - - - - - - - - - - - - k59_898728_1 926554.KI912673_gene2857 1.21e-33 130.0 COG1680@1|root,COG1680@2|Bacteria,1WMSE@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus V Beta-lactamase - - - - - - - - - - - - Beta-lactamase k59_615432_1 391603.FBALC1_03622 9.4e-75 236.0 COG1012@1|root,COG1012@2|Bacteria,4NEB7@976|Bacteroidetes,1HWQG@117743|Flavobacteriia 976|Bacteroidetes C Belongs to the aldehyde dehydrogenase family - - 1.2.1.32,1.2.1.85 ko:K10217 ko00362,ko00380,ko00622,ko01100,ko01120,ko01220,map00362,map00380,map00622,map01100,map01120,map01220 M00038,M00569 R02762,R03889,R05353 RC00218,RC00254 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_838362_1 580332.Slit_0825 3.72e-19 86.7 COG0247@1|root,COG0247@2|Bacteria,1MWTK@1224|Proteobacteria,2VISA@28216|Betaproteobacteria 28216|Betaproteobacteria C glycolate oxidase iron-sulfur subunit glcF - - ko:K11473 ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130 - R00475 RC00042 ko00000,ko00001 - - - CCG,Fer4_7,Fer4_8 k59_838362_2 232721.Ajs_0166 1.19e-07 55.8 COG0277@1|root,COG0277@2|Bacteria,1MVYV@1224|Proteobacteria,2VHUQ@28216|Betaproteobacteria,4AAAA@80864|Comamonadaceae 28216|Betaproteobacteria C PFAM FAD linked oxidase domain protein glcE - - ko:K11472 ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130 - R00475 RC00042 ko00000,ko00001 - - - FAD-oxidase_C,FAD_binding_4 k59_1344731_1 553385.JEMF01000007_gene1838 6.83e-36 131.0 COG0583@1|root,COG0583@2|Bacteria,1NSNV@1224|Proteobacteria,1RPNG@1236|Gammaproteobacteria,1XHP1@135619|Oceanospirillales 135619|Oceanospirillales K transcriptional regulator - - - - - - - - - - - - HTH_1,LysR_substrate k59_1344731_2 317013.NY99_03440 1.13e-47 165.0 COG0065@1|root,COG0065@2|Bacteria,1MVYR@1224|Proteobacteria,1RMF6@1236|Gammaproteobacteria,1X3KZ@135614|Xanthomonadales 135614|Xanthomonadales E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate leuC - 4.2.1.33,4.2.1.35 ko:K01703 ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230 M00432,M00535 R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170 RC00497,RC00976,RC00977,RC01041,RC01046,RC03072 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase k59_898734_1 273121.WS0680 2.89e-40 147.0 COG0615@1|root,COG2870@1|root,COG0615@2|Bacteria,COG2870@2|Bacteria,1MV3Z@1224|Proteobacteria,42MBC@68525|delta/epsilon subdivisions,2YMZG@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria F Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose hldE - 2.7.1.167,2.7.7.70 ko:K03272 ko00540,ko01100,map00540,map01100 M00064 R05644,R05646 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000,ko01005 - - - CTP_transf_like,PfkB k59_898734_2 926550.CLDAP_26430 1.91e-23 97.8 COG0388@1|root,COG0388@2|Bacteria,2G6KM@200795|Chloroflexi 200795|Chloroflexi S PFAM Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase - - 3.5.1.53 ko:K11206,ko:K12251 ko00330,ko01100,map00330,map01100 - R01152 RC00096 ko00000,ko00001,ko01000 - - - CN_hydrolase k59_949533_1 1367847.JCM7686_1175 2.77e-17 80.1 COG0583@1|root,COG0583@2|Bacteria,1R4QT@1224|Proteobacteria,2TRGQ@28211|Alphaproteobacteria,2PUA2@265|Paracoccus 28211|Alphaproteobacteria K LysR substrate binding domain - - - ko:K21645 - - - - ko00000,ko03000 - - - HTH_1,LysR_substrate k59_1629952_1 391625.PPSIR1_06878 2.55e-63 197.0 COG0537@1|root,COG0537@2|Bacteria,1PDTP@1224|Proteobacteria,42UAD@68525|delta/epsilon subdivisions,2WS0J@28221|Deltaproteobacteria,2Z2ZP@29|Myxococcales 28221|Deltaproteobacteria FG HIT domain - - - ko:K02503 - - - - ko00000,ko04147 - - - HIT k59_1005195_2 1229909.NSED_02630 3.56e-80 247.0 COG1064@1|root,arCOG01455@2157|Archaea,41SA9@651137|Thaumarchaeota 651137|Thaumarchaeota C PFAM Alcohol dehydrogenase GroES-like domain - - 1.1.1.1 ko:K13953 ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220 - R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310 RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273 ko00000,ko00001,ko01000 - - - ADH_N,ADH_zinc_N k59_50109_2 378806.STAUR_0004 3.3e-06 53.9 COG4968@1|root,COG4968@2|Bacteria,1QXV9@1224|Proteobacteria,42VR9@68525|delta/epsilon subdivisions,2WRJV@28221|Deltaproteobacteria,2YW4P@29|Myxococcales 28221|Deltaproteobacteria NU Type IV pilin PilA pilA GO:0005575,GO:0005623,GO:0009289,GO:0042995,GO:0044464 - ko:K02650 ko02020,map02020 - - - ko00000,ko00001,ko02035,ko02044 3.A.15.2 - - N_methyl,Pilin_PilA k59_1005199_1 161156.JQKW01000007_gene699 8.58e-96 297.0 COG0504@1|root,COG0504@2|Bacteria,2GHMU@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria F Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates pyrG - 6.3.4.2 ko:K01937 ko00240,ko01100,map00240,map01100 M00052 R00571,R00573 RC00010,RC00074 ko00000,ko00001,ko00002,ko01000 - - - CTP_synth_N,GATase k59_390496_1 926550.CLDAP_25350 2e-07 56.6 COG1040@1|root,COG1040@2|Bacteria,2G6WB@200795|Chloroflexi 200795|Chloroflexi S competence protein - - - - - - - - - - - - Pribosyltran k59_1519674_1 1210884.HG799469_gene14130 1.2e-85 259.0 COG1611@1|root,COG1611@2|Bacteria,2J21H@203682|Planctomycetes 203682|Planctomycetes S Possible lysine decarboxylase - - - - - - - - - - - - Lysine_decarbox k59_615464_1 1288494.EBAPG3_8200 1.58e-83 259.0 COG0766@1|root,COG0766@2|Bacteria,1MUH7@1224|Proteobacteria,2VHZN@28216|Betaproteobacteria,371PY@32003|Nitrosomonadales 28216|Betaproteobacteria M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine murA - 2.5.1.7 ko:K00790 ko00520,ko00550,ko01100,map00520,map00550,map01100 - R00660 RC00350 ko00000,ko00001,ko01000,ko01011 - - - EPSP_synthase k59_1577218_1 1123261.AXDW01000002_gene1694 1.18e-14 72.4 COG0625@1|root,COG0625@2|Bacteria,1REDI@1224|Proteobacteria,1S13N@1236|Gammaproteobacteria,1X4XE@135614|Xanthomonadales 135614|Xanthomonadales O Belongs to the GST superfamily gst5 - 2.5.1.18 ko:K00799 ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418 - R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905 RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944 ko00000,ko00001,ko01000,ko02000 1.A.12.2.2,1.A.12.3.2 - - GST_C,GST_N,GST_N_3 k59_1344763_1 870187.Thini_3856 2.83e-17 81.3 28KEQ@1|root,2ZA0Y@2|Bacteria,1RBS9@1224|Proteobacteria,1RZ6X@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Short C-terminal domain - - - - - - - - - - - - SHOCT k59_949560_1 716544.wcw_0593 1.5e-27 122.0 COG0086@1|root,COG0086@2|Bacteria,2JFCX@204428|Chlamydiae 204428|Chlamydiae K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoC - 2.7.7.6 ko:K03046 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5 k59_1519692_1 1114964.L485_16570 5.03e-60 204.0 COG1629@1|root,COG4771@2|Bacteria,1MVFB@1224|Proteobacteria,2U0N7@28211|Alphaproteobacteria,2KEFU@204457|Sphingomonadales 204457|Sphingomonadales P TonB-dependent receptor plug - - - - - - - - - - - - Plug,TonB_dep_Rec k59_1233983_1 998674.ATTE01000001_gene668 4.4e-06 49.3 COG0149@1|root,COG0149@2|Bacteria,1MWK5@1224|Proteobacteria,1RM8I@1236|Gammaproteobacteria,4608G@72273|Thiotrichales 72273|Thiotrichales G Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) tpiA - 5.3.1.1 ko:K01803 ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003 R01015 RC00423 ko00000,ko00001,ko00002,ko01000,ko04147 - - - TIM k59_1233983_2 314287.GB2207_10633 1.66e-33 128.0 COG1109@1|root,COG1109@2|Bacteria,1MU24@1224|Proteobacteria,1RMR2@1236|Gammaproteobacteria,1J55X@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria G Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate glmM - 5.4.2.10 ko:K03431 ko00520,ko01100,ko01130,map00520,map01100,map01130 - R02060 RC00408 ko00000,ko00001,ko01000 - - - PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV k59_1066470_1 436308.Nmar_0686 6.39e-51 177.0 COG0018@1|root,arCOG00487@2157|Archaea,41SAI@651137|Thaumarchaeota 651137|Thaumarchaeota J Belongs to the class-I aminoacyl-tRNA synthetase family argS - 6.1.1.19 ko:K01887 ko00970,map00970 M00359,M00360 R03646 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d k59_552405_1 198214.SF2743 2.73e-67 204.0 COG0375@1|root,COG0375@2|Bacteria,1MZJH@1224|Proteobacteria,1S5WG@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Probably plays a role in a hydrogenase nickel cofactor insertion step hypA GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009898,GO:0010467,GO:0016020,GO:0016151,GO:0019538,GO:0019897,GO:0019898,GO:0031234,GO:0043167,GO:0043169,GO:0043170,GO:0044238,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0046872,GO:0046914,GO:0051604,GO:0071704,GO:0071944,GO:0098552,GO:0098562,GO:1901564 - ko:K04651 - - - - ko00000,ko03110 - - - HypA k59_1630939_1 316407.85676903 1.38e-124 354.0 COG3040@1|root,COG3040@2|Bacteria,1RDAI@1224|Proteobacteria,1S3PW@1236|Gammaproteobacteria,3XMI7@561|Escherichia 1236|Gammaproteobacteria M Involved in the storage or transport of lipids necessary for membrane maintenance under stressful conditions. Displays a binding preference for lysophospholipids blc GO:0005575,GO:0005623,GO:0006950,GO:0006974,GO:0008150,GO:0009279,GO:0009987,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0033554,GO:0044462,GO:0044464,GO:0050896,GO:0051716,GO:0071944 - ko:K03098 - - - - ko00000,ko04147 - - - Lipocalin_2 k59_1408365_1 1144313.PMI10_03581 2.24e-16 77.8 COG0492@1|root,COG0492@2|Bacteria,4NEC8@976|Bacteroidetes,1HWPW@117743|Flavobacteriia,2NT1J@237|Flavobacterium 976|Bacteroidetes O pyridine nucleotide-disulfide oxidoreductase - - - - - - - - - - - - Pyr_redox_2 k59_1751223_2 710421.Mycch_4037 1.36e-14 74.3 COG0394@1|root,COG0394@2|Bacteria,2IHR3@201174|Actinobacteria,2352Q@1762|Mycobacteriaceae 201174|Actinobacteria T Low molecular weight phosphotyrosine protein phosphatase - - 1.20.4.1,2.8.4.2 ko:K03741,ko:K18701 - - - - ko00000,ko01000 - - - LMWPc k59_1751223_5 1229909.NSED_02425 2.9e-72 227.0 COG3329@1|root,arCOG11287@2157|Archaea 2157|Archaea S Na+-dependent bicarbonate transporter superfamily - - - ko:K07086 - - - - ko00000 - - - Sbt_1 k59_1013971_1 35754.JNYJ01000029_gene9532 6.61e-17 84.0 COG0810@1|root,COG0810@2|Bacteria,2IMCG@201174|Actinobacteria,4DEFA@85008|Micromonosporales 201174|Actinobacteria M Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins - - - - - - - - - - - - DUF2637 k59_958702_1 158500.BV97_04472 5.86e-110 327.0 COG0446@1|root,COG0446@2|Bacteria,1NR3M@1224|Proteobacteria,2TS0K@28211|Alphaproteobacteria,2K12H@204457|Sphingomonadales 204457|Sphingomonadales S pyridine nucleotide-disulfide oxidoreductase - - 1.18.1.3 ko:K00529 ko00071,ko00360,ko01120,ko01220,map00071,map00360,map01120,map01220 M00545 R02000,R06782,R06783 RC00098 br01602,ko00000,ko00001,ko00002,ko01000 - - - Pyr_redox_2,Reductase_C k59_1803836_1 314265.R2601_08676 2.04e-80 251.0 COG1305@1|root,COG1305@2|Bacteria,1MVAG@1224|Proteobacteria,2UPUE@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Transglutaminase/protease-like homologues - - - - - - - - - - - - Bact_transglu_N,Transglut_core k59_1803836_2 1403313.AXBR01000009_gene812 1.02e-06 54.7 COG3860@1|root,COG3860@2|Bacteria,1TPHH@1239|Firmicutes,4HCHE@91061|Bacilli,1ZEMD@1386|Bacillus 91061|Bacilli K Uncharacterized protein conserved in bacteria (DUF2087) - - - - - - - - - - - - DUF2087,GerE k59_1803836_3 331113.SNE_A22520 2.07e-38 134.0 COG1917@1|root,COG1917@2|Bacteria 2|Bacteria L Cupin 2, conserved barrel domain protein - - - - - - - - - - - - AraC_binding,Cupin_2,Cupin_7,HTH_18 k59_1694524_1 316067.Geob_1805 3.17e-93 279.0 COG3618@1|root,COG3618@2|Bacteria,1PF81@1224|Proteobacteria,42Z8K@68525|delta/epsilon subdivisions,2WU9E@28221|Deltaproteobacteria,43TN1@69541|Desulfuromonadales 28221|Deltaproteobacteria S Amidohydrolase - - - - - - - - - - - - Amidohydro_2 k59_1803853_1 1144305.PMI02_01777 7.32e-49 163.0 COG0596@1|root,COG0596@2|Bacteria,1P092@1224|Proteobacteria,2UV5T@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Alpha beta hydrolase - - - - - - - - - - - - Abhydrolase_1 k59_561708_1 626887.J057_06831 2.99e-36 141.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,464AK@72275|Alteromonadaceae 1236|Gammaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_450505_1 251229.Chro_5554 3.96e-27 115.0 COG0477@1|root,COG2814@2|Bacteria,1G1F0@1117|Cyanobacteria,3VMYG@52604|Pleurocapsales 1117|Cyanobacteria EGP Major Facilitator Superfamily - - - - - - - - - - - - MFS_1,Sugar_tr k59_450505_2 421052.F945_00323 7.74e-66 212.0 COG0604@1|root,COG0604@2|Bacteria,1MWBD@1224|Proteobacteria,1RPCQ@1236|Gammaproteobacteria,3NKCN@468|Moraxellaceae 1236|Gammaproteobacteria C Zinc-binding dehydrogenase - - 1.6.5.5 ko:K00344 - - - - ko00000,ko01000 - - - ADH_N,ADH_zinc_N k59_1128649_1 1123236.KB899376_gene583 1.23e-156 479.0 COG3507@1|root,COG3507@2|Bacteria,1R4H2@1224|Proteobacteria,1RSCC@1236|Gammaproteobacteria,465D9@72275|Alteromonadaceae 1236|Gammaproteobacteria G C-terminal of Glycosyl hydrolases family 43 - - 3.2.1.99 ko:K06113 - - - - ko00000,ko01000 - GH43 - GH43_C,Glyco_hydro_43,Laminin_G_3 k59_1803866_1 555793.WSK_0022 1.43e-90 270.0 COG0159@1|root,COG0159@2|Bacteria,1MXJV@1224|Proteobacteria,2TQN2@28211|Alphaproteobacteria,2K0XH@204457|Sphingomonadales 204457|Sphingomonadales E The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate trpA - 4.2.1.20 ko:K01695 ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230 M00023 R00674,R02340,R02722 RC00209,RC00210,RC00700,RC00701,RC02868 ko00000,ko00001,ko00002,ko01000 - - - Trp_syntA k59_1803866_2 1384056.N787_01995 2.09e-22 90.1 COG0662@1|root,COG0662@2|Bacteria 2|Bacteria G Cupin 2, conserved barrel domain protein - - - - - - - - - - - - 3-HAO,Cupin_2,HTH_18 k59_788009_1 713586.KB900536_gene1177 2.58e-197 588.0 COG0085@1|root,COG0085@2|Bacteria,1MUC4@1224|Proteobacteria,1RMK0@1236|Gammaproteobacteria,1WX4P@135613|Chromatiales 135613|Chromatiales K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoB - 2.7.7.6 ko:K03043 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7 k59_1467410_1 1457393.AZ09_03430 1.06e-05 51.2 COG1391@1|root,COG1391@2|Bacteria,1MU4I@1224|Proteobacteria,2TRY7@28211|Alphaproteobacteria,2JPFA@204441|Rhodospirillales 204441|Rhodospirillales H Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell glnE - 2.7.7.42,2.7.7.89 ko:K00982 - - - - ko00000,ko01000 - - - GlnD_UR_UTase,GlnE k59_1128664_1 1120977.JHUX01000004_gene2539 2.4e-14 72.8 COG0370@1|root,COG0370@2|Bacteria,1MUZC@1224|Proteobacteria,1RME9@1236|Gammaproteobacteria,3NK9Z@468|Moraxellaceae 1236|Gammaproteobacteria P Ferrous iron transport protein B feoB - - ko:K04759 - - - - ko00000,ko02000 9.A.8.1 - - FeoB_C,FeoB_N,Gate k59_1128664_2 272942.RCAP_rcc02028 3.96e-11 61.6 COG1918@1|root,COG1918@2|Bacteria,1N8DT@1224|Proteobacteria,2UFJ3@28211|Alphaproteobacteria 28211|Alphaproteobacteria P PFAM FeoA family protein feoA - - ko:K04758 - - - - ko00000,ko02000 - - - FeoA k59_450523_1 1088721.NSU_1086 1.25e-45 148.0 COG2261@1|root,COG2261@2|Bacteria,1N3E3@1224|Proteobacteria,2UEBF@28211|Alphaproteobacteria,2K6UA@204457|Sphingomonadales 204457|Sphingomonadales S Transglycosylase associated protein - - - - - - - - - - - - Transgly_assoc k59_450523_2 702113.PP1Y_AT513 5.9e-27 99.8 2AMHV@1|root,31CDG@2|Bacteria,1RGVA@1224|Proteobacteria,2U98Q@28211|Alphaproteobacteria,2K54G@204457|Sphingomonadales 204457|Sphingomonadales S Protein of unknown function (DUF1153) - - - - - - - - - - - - DUF1153 k59_1014016_1 876044.IMCC3088_2538 1.7e-79 254.0 COG3653@1|root,COG3653@2|Bacteria,1MWWY@1224|Proteobacteria,1RYI9@1236|Gammaproteobacteria 1236|Gammaproteobacteria Q COG3653 N-acyl-D-aspartate D-glutamate deacylase - - - - - - - - - - - - Amidohydro_3 k59_1014016_2 237368.SCABRO_02413 2.4e-09 60.5 29MQ2@1|root,308MT@2|Bacteria,2J179@203682|Planctomycetes 203682|Planctomycetes - - - - - - - - - - - - - - - k59_788023_1 1366050.N234_30675 2.58e-24 101.0 COG0111@1|root,COG0111@2|Bacteria,1MW1U@1224|Proteobacteria,2VPM0@28216|Betaproteobacteria,1K65S@119060|Burkholderiaceae 28216|Betaproteobacteria C D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain - - - - - - - - - - - - 2-Hacid_dh,2-Hacid_dh_C k59_788023_2 1307759.JOMJ01000004_gene2605 1.46e-14 75.9 COG4089@1|root,COG4089@2|Bacteria,1MV8K@1224|Proteobacteria,42SVR@68525|delta/epsilon subdivisions,2WPHU@28221|Deltaproteobacteria,2M8RJ@213115|Desulfovibrionales 28221|Deltaproteobacteria S Protein of unknown function (DUF1614) - - - - - - - - - - - - DUF1614 k59_1751300_1 1144305.PMI02_00508 1.25e-17 80.9 COG3751@1|root,COG3751@2|Bacteria,1NG7K@1224|Proteobacteria,2VG2X@28211|Alphaproteobacteria,2KE11@204457|Sphingomonadales 204457|Sphingomonadales O Prolyl 4-hydroxylase alpha subunit homologues. - - 1.14.11.2 ko:K00472 ko00330,ko01100,map00330,map01100 - R01252 RC00478 ko00000,ko00001,ko01000 - - - 2OG-FeII_Oxy_3 k59_1128695_1 1463900.JOIX01000014_gene2109 7.08e-41 145.0 COG1011@1|root,COG1011@2|Bacteria,2HHHH@201174|Actinobacteria 201174|Actinobacteria S haloacid dehalogenase dehII - 3.8.1.2 ko:K01560 ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120 - R05287 RC00697 ko00000,ko00001,ko01000 - - - HAD_2,Hydrolase k59_676785_1 502025.Hoch_2204 1.96e-23 102.0 COG1835@1|root,COG1835@2|Bacteria,1MYXY@1224|Proteobacteria,42VFT@68525|delta/epsilon subdivisions,2WRGM@28221|Deltaproteobacteria 28221|Deltaproteobacteria I Acyltransferase family - - - - - - - - - - - - Acyl_transf_3 k59_1353844_1 1190606.AJYG01000077_gene4127 2.72e-146 436.0 COG1251@1|root,COG1251@2|Bacteria,1MW58@1224|Proteobacteria,1RNGY@1236|Gammaproteobacteria,1XUM5@135623|Vibrionales 135623|Vibrionales C Belongs to the nitrite and sulfite reductase 4Fe-4S domain family - - - - - - - - - - - - Fer2_BFD,NIR_SIR,NIR_SIR_ferr,Pyr_redox_2 k59_1014044_1 4932.Q0250 2.88e-108 315.0 COG1622@1|root,KOG4767@2759|Eukaryota,38FF8@33154|Opisthokonta,3NUKK@4751|Fungi,3QKBA@4890|Ascomycota,3RRR1@4891|Saccharomycetes,3S2BR@4893|Saccharomycetaceae 4751|Fungi C cytochrome-c oxidase activity cox2 GO:0003674,GO:0003824,GO:0004129,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005740,GO:0005743,GO:0005746,GO:0005751,GO:0006091,GO:0006119,GO:0006123,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009055,GO:0009060,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015002,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015672,GO:0015980,GO:0016020,GO:0016021,GO:0016310,GO:0016491,GO:0016675,GO:0016676,GO:0017144,GO:0019637,GO:0019646,GO:0019693,GO:0019866,GO:0022857,GO:0022890,GO:0022900,GO:0022904,GO:0031090,GO:0031224,GO:0031966,GO:0031967,GO:0031975,GO:0032991,GO:0034220,GO:0034641,GO:0042773,GO:0042775,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044281,GO:0044422,GO:0044424,GO:0044425,GO:0044429,GO:0044444,GO:0044446,GO:0044455,GO:0044464,GO:0045277,GO:0045333,GO:0046034,GO:0046483,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0055114,GO:0070069,GO:0070469,GO:0071704,GO:0072521,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098798,GO:0098800,GO:0098803,GO:1901135,GO:1901360,GO:1901564,GO:1902600 - ko:K02261 ko00190,ko01100,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map04260,map04714,map04932,map05010,map05012,map05016 M00154 - - ko00000,ko00001,ko00002,ko03029 3.D.4.11,3.D.4.7,3.D.4.8 - - COX2,COX2_TM k59_1751339_1 1122612.AUBA01000015_gene874 3.26e-48 162.0 COG4221@1|root,COG4221@2|Bacteria,1MVYG@1224|Proteobacteria,2TSTP@28211|Alphaproteobacteria,2K8WB@204457|Sphingomonadales 204457|Sphingomonadales S KR domain - - - - - - - - - - - - adh_short k59_1751339_2 702113.PP1Y_AT11846 1.11e-45 155.0 COG4221@1|root,COG4221@2|Bacteria,1MVYG@1224|Proteobacteria,2TSTP@28211|Alphaproteobacteria,2K5TA@204457|Sphingomonadales 204457|Sphingomonadales S Belongs to the short-chain dehydrogenases reductases (SDR) family - - - - - - - - - - - - adh_short k59_450595_1 1121381.JNIV01000031_gene2407 4.88e-22 101.0 COG0433@1|root,COG0433@2|Bacteria,1WM64@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus D nuclear chromosome segregation - - - - - - - - - - - - - k59_450605_1 981384.AEYW01000023_gene3889 5.31e-40 147.0 COG1653@1|root,COG1653@2|Bacteria,1MXZJ@1224|Proteobacteria,2TSFY@28211|Alphaproteobacteria,4NBPJ@97050|Ruegeria 28211|Alphaproteobacteria G Extracellular solute-binding protein, family 1 aglE - - ko:K10232 ko02010,map02010 M00201 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.32,3.A.1.1.8 - - SBP_bac_1,SBP_bac_8 k59_958831_1 1121912.AUHD01000014_gene1051 3.86e-10 59.3 COG0497@1|root,COG0497@2|Bacteria,4NE2U@976|Bacteroidetes,1HY9M@117743|Flavobacteriia 976|Bacteroidetes L DNA recombination - - - - - - - - - - - - - k59_958831_2 398720.MED217_12599 7.17e-13 68.9 COG2220@1|root,COG2220@2|Bacteria,4NFJ4@976|Bacteroidetes,1HYS8@117743|Flavobacteriia,2XHXQ@283735|Leeuwenhoekiella 976|Bacteroidetes S Beta-lactamase superfamily domain - - - - - - - - - - - - Lactamase_B_3 k59_1128737_1 1122137.AQXF01000002_gene240 1.85e-89 274.0 COG1686@1|root,COG1686@2|Bacteria,1MUU7@1224|Proteobacteria,2TS1P@28211|Alphaproteobacteria 28211|Alphaproteobacteria M Belongs to the peptidase S11 family dacC - 3.4.16.4 ko:K07258 ko00550,ko01100,map00550,map01100 - - - ko00000,ko00001,ko01000,ko01002,ko01011 - - - PBP5_C,Peptidase_S11 k59_1128737_2 1333998.M2A_3254 8.84e-05 43.5 COG0125@1|root,COG0125@2|Bacteria,1MV9C@1224|Proteobacteria,2U72D@28211|Alphaproteobacteria,4BQ9N@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria F Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis tmk GO:0003674,GO:0003824,GO:0004798,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006227,GO:0006233,GO:0006235,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009165,GO:0009186,GO:0009189,GO:0009196,GO:0009197,GO:0009200,GO:0009202,GO:0009211,GO:0009212,GO:0009219,GO:0009221,GO:0009262,GO:0009263,GO:0009265,GO:0009394,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019692,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046072,GO:0046075,GO:0046077,GO:0046385,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.4.9 ko:K00943 ko00240,ko01100,map00240,map01100 M00053 R02094,R02098 RC00002 ko00000,ko00001,ko00002,ko01000 - - - Thymidylate_kin k59_1297871_1 1123355.JHYO01000007_gene477 3.63e-54 179.0 COG1024@1|root,COG1024@2|Bacteria,1MXBB@1224|Proteobacteria,2TU4V@28211|Alphaproteobacteria,36YFA@31993|Methylocystaceae 28211|Alphaproteobacteria I Enoyl-CoA hydratase/isomerase - - - - - - - - - - - - ECH_1 k59_1297882_1 748280.NH8B_3185 1.53e-51 181.0 COG0322@1|root,COG0322@2|Bacteria,1MV38@1224|Proteobacteria,2VIM4@28216|Betaproteobacteria,2KPQ4@206351|Neisseriales 206351|Neisseriales L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision uvrC - - ko:K03703 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - GIY-YIG,HHH,HHH_2,HHH_5,UVR,UvrC_HhH_N k59_1694666_1 1177154.Y5S_02077 1.93e-34 136.0 COG0457@1|root,COG0666@1|root,COG3209@1|root,COG3292@1|root,COG4995@1|root,COG0457@2|Bacteria,COG0666@2|Bacteria,COG3209@2|Bacteria,COG3292@2|Bacteria,COG4995@2|Bacteria,1MWRF@1224|Proteobacteria,1T431@1236|Gammaproteobacteria,1XMNE@135619|Oceanospirillales 135619|Oceanospirillales T CHAT domain - - - - - - - - - - - - CHAT k59_676851_1 436308.Nmar_0036 5.95e-36 122.0 arCOG08815@1|root,arCOG08815@2157|Archaea,41T9N@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_958857_1 316275.VSAL_I2795 4.07e-22 94.0 COG0053@1|root,COG0053@2|Bacteria,1MUDS@1224|Proteobacteria,1RNS2@1236|Gammaproteobacteria,1XSMN@135623|Vibrionales 135623|Vibrionales P Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family fieF - - ko:K13283 - - - - ko00000,ko02000 2.A.4.7.1 - - Cation_efflux,ZT_dimer k59_958857_2 195105.CN97_05865 1.54e-20 90.9 COG0711@1|root,COG0711@2|Bacteria,1N0P5@1224|Proteobacteria,2U5DD@28211|Alphaproteobacteria 28211|Alphaproteobacteria C Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) atpF - - ko:K02109 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt_B k59_1751389_1 1415778.JQMM01000001_gene499 2.1e-126 371.0 COG0452@1|root,COG0452@2|Bacteria,1MVQP@1224|Proteobacteria,1RMKQ@1236|Gammaproteobacteria,1J4KE@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine coaBC GO:0000166,GO:0003674,GO:0003824,GO:0004632,GO:0004633,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0010181,GO:0015936,GO:0015937,GO:0016829,GO:0016830,GO:0016831,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0032553,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0036094,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 4.1.1.36,6.3.2.5 ko:K13038 ko00770,ko01100,map00770,map01100 M00120 R03269,R04231 RC00064,RC00090,RC00822 ko00000,ko00001,ko00002,ko01000 - - iEC042_1314.EC042_3945,iECUMN_1333.ECUMN_4154,iJN746.PP_5285,iSBO_1134.SBO_3641 DFP,Flavoprotein k59_450650_1 266117.Rxyl_0815 1.23e-80 250.0 COG0516@1|root,COG0516@2|Bacteria,2GKVS@201174|Actinobacteria,4CP9K@84995|Rubrobacteria 84995|Rubrobacteria F IMP dehydrogenase GMP reductase - - 1.1.1.205 ko:K00088 ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 M00050 R01130,R08240 RC00143,RC02207 ko00000,ko00001,ko00002,ko01000,ko04147 - - - IMPDH k59_1694685_1 436308.Nmar_1085 8.16e-49 173.0 COG0458@1|root,arCOG01594@2157|Archaea,41SBF@651137|Thaumarchaeota 651137|Thaumarchaeota E MGS-like domain - - 6.3.5.5 ko:K01955 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - - CPSase_L_D2,CPSase_L_D3,MGS k59_1694685_2 1229909.NSED_06310 7.82e-103 303.0 COG1407@1|root,arCOG01150@2157|Archaea,41SJB@651137|Thaumarchaeota 651137|Thaumarchaeota S Calcineurin-like phosphoesterase - - - ko:K06953 - - - - ko00000 - - - Metallophos k59_1014108_1 861299.J421_1072 3.7e-84 260.0 COG0592@1|root,COG0592@2|Bacteria,1ZT22@142182|Gemmatimonadetes 142182|Gemmatimonadetes L Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria - - 2.7.7.7 ko:K02338 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_beta,DNA_pol3_beta_3 k59_1694706_1 156578.ATW7_11911 5.91e-25 107.0 COG4775@1|root,COG4775@2|Bacteria,1PT0R@1224|Proteobacteria,1RPWY@1236|Gammaproteobacteria 1236|Gammaproteobacteria M COG4775 Outer membrane protein protective antigen OMA87 - - - - - - - - - - - - Bac_surface_Ag,ShlB k59_1467566_2 589865.DaAHT2_1075 3.29e-24 100.0 COG0774@1|root,COG0774@2|Bacteria,1MV6T@1224|Proteobacteria,42MVM@68525|delta/epsilon subdivisions,2WJ4I@28221|Deltaproteobacteria,2MHWY@213118|Desulfobacterales 28221|Deltaproteobacteria M Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis lpxC - 3.5.1.108 ko:K02535,ko:K13599 ko00540,ko01100,ko02020,map00540,map01100,map02020 M00060,M00498 R04587 RC00166,RC00300 ko00000,ko00001,ko00002,ko01000,ko01005,ko02022 - - - LpxC k59_505922_1 89187.ISM_12325 3.76e-35 135.0 COG1053@1|root,COG1053@2|Bacteria,1MU5M@1224|Proteobacteria,2U1QF@28211|Alphaproteobacteria,46PWA@74030|Roseovarius 28211|Alphaproteobacteria C COG1053 Succinate dehydrogenase fumarate reductase, flavoprotein subunit - - 1.3.5.4 ko:K00244 ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020 M00009,M00011,M00150,M00173 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,Succ_DH_flav_C k59_505922_2 1429916.X566_04050 7.86e-43 146.0 COG4032@1|root,COG4032@2|Bacteria,1P0HU@1224|Proteobacteria,2TRJ2@28211|Alphaproteobacteria,3JQMU@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S Thiamine pyrophosphate enzyme, N-terminal TPP binding domain - - 4.1.1.79 ko:K06034 ko00680,ko01120,map00680,map01120 M00358 R05774 RC00506 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_N k59_958909_1 1120931.KB893945_gene340 4.52e-57 188.0 COG0040@1|root,COG0040@2|Bacteria,1MUCY@1224|Proteobacteria,1RNAX@1236|Gammaproteobacteria,1Y6ZD@135625|Pasteurellales 135625|Pasteurellales F ATP phosphoribosyltransferase hisG GO:0000105,GO:0003674,GO:0003824,GO:0003879,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.17 ko:K00765 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R01071 RC02819,RC03200 ko00000,ko00001,ko00002,ko01000 - - - HisG,HisG_C k59_1014153_2 211114.JOEF01000050_gene4672 2.24e-53 179.0 COG0451@1|root,COG0451@2|Bacteria,2GMHH@201174|Actinobacteria,4E213@85010|Pseudonocardiales 201174|Actinobacteria GM 3-beta hydroxysteroid dehydrogenase/isomerase family - GO:0000166,GO:0003674,GO:0003824,GO:0003854,GO:0004769,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006629,GO:0008150,GO:0008152,GO:0008202,GO:0016020,GO:0016229,GO:0016491,GO:0016614,GO:0016616,GO:0016853,GO:0016860,GO:0016863,GO:0030283,GO:0033764,GO:0036094,GO:0043167,GO:0043168,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0070403,GO:0071704,GO:0071944,GO:0097159,GO:1901265,GO:1901360,GO:1901363 1.1.1.145,1.1.1.412,5.3.3.1 ko:K16045,ko:K22320 ko00984,ko01120,map00984,map01120 - R09920 RC00146 ko00000,ko00001,ko01000 - - - 3Beta_HSD,Epimerase k59_1243398_2 1123386.AUIW01000002_gene1180 8.78e-06 48.5 COG0492@1|root,COG0492@2|Bacteria,1WJ2R@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus O PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase - - 1.8.1.9 ko:K00384 ko00450,map00450 - R02016,R03596,R09372 RC00013,RC02518,RC02873 ko00000,ko00001,ko01000 - - - Pyr_redox_3 k59_1017554_1 484022.Fphi_0291 1.9e-27 116.0 COG1807@1|root,COG1807@2|Bacteria,1NMIZ@1224|Proteobacteria,1RMA2@1236|Gammaproteobacteria,460NV@72273|Thiotrichales 72273|Thiotrichales M Dolichyl-phosphate-mannose-protein mannosyltransferase - - - - - - - - - - - - PMT_2 k59_960894_2 1127673.GLIP_0128 2.62e-08 55.1 COG1300@1|root,COG1300@2|Bacteria,1Q1GN@1224|Proteobacteria,1RR61@1236|Gammaproteobacteria,466VE@72275|Alteromonadaceae 1236|Gammaproteobacteria S Stage II sporulation protein M - - - - - - - - - - - - SpoIIM k59_1017558_1 1324957.K933_04306 9.23e-32 126.0 COG0168@1|root,arCOG04145@2157|Archaea,2XT89@28890|Euryarchaeota,23TBX@183963|Halobacteria 183963|Halobacteria P COG0168 Trk-type K transport systems, membrane components trkH - - ko:K03498 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - - TrkH k59_169977_1 765913.ThidrDRAFT_1052 1.04e-93 298.0 COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,1RN2C@1236|Gammaproteobacteria,1WVXM@135613|Chromatiales 135613|Chromatiales P heavy metal translocating P-type ATPase - - 3.6.3.4,3.6.3.54 ko:K01533,ko:K17686 ko01524,ko04016,map01524,map04016 - R00086 RC00002 ko00000,ko00001,ko01000 3.A.3.5 - - E1-E2_ATPase,HMA,Hydrolase k59_1130516_1 1158318.ATXC01000001_gene1233 8.68e-11 68.2 COG1541@1|root,COG1541@2|Bacteria 2|Bacteria H phenylacetate-CoA ligase activity paaK2 - 6.2.1.30 ko:K01912 ko00360,ko01120,ko05111,map00360,map01120,map05111 - R02539 RC00004,RC00014 ko00000,ko00001,ko01000 - - - AMP-binding,AMP-binding_C_2 k59_283113_1 391735.Veis_3319 1.48e-54 185.0 COG1960@1|root,COG1960@2|Bacteria,1MX17@1224|Proteobacteria,2VM2C@28216|Betaproteobacteria,4AC7G@80864|Comamonadaceae 28216|Betaproteobacteria C acyl-CoA dehydrogenase - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_339546_1 1120970.AUBZ01000029_gene1054 1.51e-79 252.0 COG3303@1|root,COG3303@2|Bacteria,1R5JF@1224|Proteobacteria,1S13K@1236|Gammaproteobacteria,4667Z@72275|Alteromonadaceae 1236|Gammaproteobacteria P Cytochrome c3 - - - - - - - - - - - - Cytochrom_C552,Cytochrom_c3_2 k59_1469476_1 118173.KB235910_gene5045 1.17e-55 196.0 COG0506@1|root,COG1012@1|root,COG0506@2|Bacteria,COG1012@2|Bacteria,1G217@1117|Cyanobacteria,1H72M@1150|Oscillatoriales 1117|Cyanobacteria CE Belongs to the aldehyde dehydrogenase family putA - 1.2.1.88,1.5.5.2 ko:K13821 ko00250,ko00330,ko01100,ko01110,ko01130,map00250,map00330,map01100,map01110,map01130 - R00245,R00707,R00708,R01253,R04444,R04445,R05051 RC00080,RC00083,RC00216,RC00242,RC00255 ko00000,ko00001,ko01000,ko03000 - - - Aldedh,Pro_dh k59_395882_1 383381.EH30_00440 5.79e-71 231.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,2TQR7@28211|Alphaproteobacteria,2K1AE@204457|Sphingomonadales 204457|Sphingomonadales NT chemotaxis - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - MCPsignal,Protoglobin k59_479_1 876044.IMCC3088_1463 3.26e-45 155.0 COG0158@1|root,COG0158@2|Bacteria,1MW0E@1224|Proteobacteria,1RNFF@1236|Gammaproteobacteria,1J4E2@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria G Belongs to the FBPase class 1 family fbp GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005984,GO:0005985,GO:0005986,GO:0005996,GO:0006000,GO:0006002,GO:0006006,GO:0006094,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009058,GO:0009311,GO:0009312,GO:0009987,GO:0016043,GO:0016051,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019203,GO:0019318,GO:0019319,GO:0019637,GO:0022607,GO:0030388,GO:0034637,GO:0042132,GO:0042578,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044262,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046351,GO:0046364,GO:0050308,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0065003,GO:0071704,GO:0071840,GO:1901135,GO:1901576 3.1.3.11 ko:K03841 ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko04152,ko04910,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map04152,map04910 M00003,M00165,M00167,M00344 R00762,R04780 RC00017 ko00000,ko00001,ko00002,ko01000,ko04147 - - iUTI89_1310.UTI89_C4836,ic_1306.c5329 FBPase k59_565610_1 498211.CJA_0076 1.06e-92 293.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,1RMH0@1236|Gammaproteobacteria,1FGN1@10|Cellvibrio 1236|Gammaproteobacteria NT Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer). pilJ - - ko:K02660 ko02020,ko02025,map02020,map02025 - - - ko00000,ko00001,ko02035,ko02044 - - - MCPsignal,PilJ k59_1243426_1 1535287.JP74_22965 1.06e-42 150.0 COG0101@1|root,COG0101@2|Bacteria,1MUYI@1224|Proteobacteria,2TR57@28211|Alphaproteobacteria,3N64K@45401|Hyphomicrobiaceae 28211|Alphaproteobacteria J Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs truA GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016853,GO:0016866,GO:0031119,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360 5.4.99.12 ko:K06173 - - - - ko00000,ko01000,ko03016 - - - PseudoU_synth_1 k59_565611_1 1297742.A176_00178 8.79e-15 73.9 COG1109@1|root,COG1109@2|Bacteria,1MU24@1224|Proteobacteria,42M6I@68525|delta/epsilon subdivisions,2WJTV@28221|Deltaproteobacteria,2YU3G@29|Myxococcales 28221|Deltaproteobacteria G Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate glmM - 5.4.2.10 ko:K03431 ko00520,ko01100,ko01130,map00520,map01100,map01130 - R02060 RC00408 ko00000,ko00001,ko01000 - - iAF987.Gmet_1886 PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV k59_113509_1 1336235.JAEG01000001_gene2488 5.16e-44 145.0 COG1610@1|root,COG1610@2|Bacteria,1RGZS@1224|Proteobacteria,2U7DJ@28211|Alphaproteobacteria,4BF16@82115|Rhizobiaceae 28211|Alphaproteobacteria S Yqey-like protein MA20_04985 - - ko:K09117 - - - - ko00000 - - - YqeY k59_678438_1 1094489.BAnh1_04270 1.64e-12 69.7 COG0329@1|root,COG0329@2|Bacteria,1MUCM@1224|Proteobacteria,2TR5W@28211|Alphaproteobacteria,48T19@772|Bartonellaceae 28211|Alphaproteobacteria E Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) dapA GO:0003674,GO:0003824,GO:0006082,GO:0006090,GO:0008150,GO:0008152,GO:0008840,GO:0009987,GO:0016829,GO:0016835,GO:0016836,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044281,GO:0071704 4.3.3.7 ko:K01714 ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R10147 RC03062,RC03063 ko00000,ko00001,ko00002,ko01000 - - - DHDPS k59_735082_1 395965.Msil_3172 5.46e-40 151.0 COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,2U0IK@28211|Alphaproteobacteria,3NC65@45404|Beijerinckiaceae 28211|Alphaproteobacteria O Found in ATP-dependent protease La (LON) MA20_45155 - 3.4.21.53 ko:K01338 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - AAA,LON_substr_bdg,Lon_C k59_960925_1 626887.J057_17885 6.5e-35 137.0 2C2C7@1|root,2Z85G@2|Bacteria,1PD07@1224|Proteobacteria,1RP6G@1236|Gammaproteobacteria,466J7@72275|Alteromonadaceae 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_1243438_1 62928.azo0838 0.00011 45.1 COG2885@1|root,COG2885@2|Bacteria,1MYBP@1224|Proteobacteria,2VR0Y@28216|Betaproteobacteria,2KVJ4@206389|Rhodocyclales 206389|Rhodocyclales M Belongs to the ompA family - - - - - - - - - - - - Gly-zipper_Omp,OmpA k59_1243438_2 690850.Desaf_0974 4.11e-25 99.0 2E8QN@1|root,3331M@2|Bacteria,1ND4I@1224|Proteobacteria,430TR@68525|delta/epsilon subdivisions,2WVZ7@28221|Deltaproteobacteria,2MF52@213115|Desulfovibrionales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_226441_1 926569.ANT_28320 2.22e-124 389.0 COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1146@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1146@2|Bacteria,2G5M1@200795|Chloroflexi 200795|Chloroflexi C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin porA - 1.2.7.1 ko:K00169,ko:K03737 ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200 M00173,M00307,M00374,M00620 R01196,R01199,R08034,R10866 RC00004,RC00250,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - EKR,Fer4_16,Fer4_6,Fer4_7,PFOR_II,POR,POR_N,TPP_enzyme_C k59_7921_2 1229909.NSED_02755 3.1e-52 167.0 COG1184@1|root,arCOG01127@2157|Archaea,41T2Z@651137|Thaumarchaeota 651137|Thaumarchaeota L NUDIX domain - - - - - - - - - - - - NUDIX k59_685269_1 1049564.TevJSym_aj00040 1.35e-164 491.0 COG2755@1|root,COG2755@2|Bacteria,1MXTS@1224|Proteobacteria,1RTPH@1236|Gammaproteobacteria,1J9AM@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Concanavalin A-like lectin/glucanases superfamily - - - - - - - - - - - - Laminin_G_3 k59_1476835_2 13690.CP98_02698 1.27e-69 226.0 COG2124@1|root,COG2124@2|Bacteria,1MY5H@1224|Proteobacteria,2TR6X@28211|Alphaproteobacteria 28211|Alphaproteobacteria Q Cytochrome P450 - - - - - - - - - - - - p450 k59_1702154_1 1229909.NSED_05125 2.74e-104 311.0 COG0133@1|root,arCOG01433@2157|Archaea,41S87@651137|Thaumarchaeota 651137|Thaumarchaeota E The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine trpB - 4.2.1.20 ko:K01696 ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230 M00023 R00674,R02340,R02722 RC00209,RC00210,RC00700,RC00701,RC02868 ko00000,ko00001,ko00002,ko01000 - - - PALP k59_1702154_2 436308.Nmar_0916 2.8e-69 216.0 COG0159@1|root,arCOG01086@2157|Archaea,41SG0@651137|Thaumarchaeota 651137|Thaumarchaeota E The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate trpA - 4.2.1.20 ko:K01695 ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230 M00023 R00674,R02340,R02722 RC00209,RC00210,RC00700,RC00701,RC02868 ko00000,ko00001,ko00002,ko01000 - - - Trp_syntA k59_1080946_1 351627.Csac_2059 2.76e-54 184.0 COG0281@1|root,COG0281@2|Bacteria,1TPJ3@1239|Firmicutes,2487U@186801|Clostridia,42F5T@68295|Thermoanaerobacterales 186801|Clostridia C PFAM malic - - 1.1.1.38 ko:K00027 ko00620,ko01200,ko02020,map00620,map01200,map02020 - R00214 RC00105 ko00000,ko00001,ko01000 - - - Malic_M,malic k59_64768_1 316407.85674655 1.11e-105 312.0 COG2055@1|root,COG2055@2|Bacteria,1MWQY@1224|Proteobacteria,1RSKW@1236|Gammaproteobacteria,3XQXU@561|Escherichia 1236|Gammaproteobacteria C AllD plays a pivotal role as a metabolic branch-point enzyme in nitrogen utilization via the assimilation of allantoin. It is able to utilize allantoin as a sole source of nitrogen under anaerobic conditions. Catalyzes the oxidation of ureidoglycolate to oxalurate allD GO:0000255,GO:0000256,GO:0003674,GO:0003824,GO:0006807,GO:0008150,GO:0008152,GO:0009040,GO:0009056,GO:0009442,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0017144,GO:0034641,GO:0042737,GO:0043603,GO:0043605,GO:0044237,GO:0044248,GO:0044270,GO:0046483,GO:0046700,GO:0055114,GO:0071704,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575 1.1.1.350 ko:K00073 ko00230,ko01120,map00230,map01120 - R02935,R02936 RC00169 ko00000,ko00001,ko01000 - - iEC042_1314.EC042_0560 Ldh_2 k59_1646306_1 278957.ABEA03000130_gene1701 1.81e-104 325.0 COG0464@1|root,COG0464@2|Bacteria 2|Bacteria O ATPase activity ycf46 - 3.6.4.6 ko:K06027 ko04138,ko04721,ko04727,ko04962,map04138,map04721,map04727,map04962 - - - ko00000,ko00001,ko01000,ko04131 1.F.1.1 - - AAA k59_1646307_1 1499967.BAYZ01000080_gene910 1.17e-10 67.8 COG5276@1|root,COG5295@1|root,COG5276@2|Bacteria,COG5295@2|Bacteria,2NRZP@2323|unclassified Bacteria 2|Bacteria M Hep Hag repeat protein - - - - - - - - - - - - Big_5,ESPR,LVIVD,YadA_anchor,YadA_head,YadA_stalk k59_1589107_1 1121921.KB898706_gene3422 4.8e-95 293.0 28KNR@1|root,2Z9F7@2|Bacteria,1NC4P@1224|Proteobacteria,1RS28@1236|Gammaproteobacteria,2PMPE@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria S Glycosyl hydrolase family 79, N-terminal domain - - - - - - - - - - - - Glyco_hydro_79n k59_1363700_1 454957.IA64_10280 7.37e-71 237.0 COG1048@1|root,COG1048@2|Bacteria,1MU9T@1224|Proteobacteria,1RN5I@1236|Gammaproteobacteria,1X3SP@135614|Xanthomonadales 135614|Xanthomonadales C Catalyzes the isomerization of citrate to isocitrate via cis-aconitate acnA - 4.2.1.3 ko:K01681 ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00173,M00740 R01324,R01325,R01900 RC00497,RC00498,RC00618 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase,Aconitase_C k59_1080958_1 91464.S7335_378 1.68e-59 191.0 COG5433@1|root,COG5433@2|Bacteria,1GJK3@1117|Cyanobacteria,1H391@1129|Synechococcus 1117|Cyanobacteria L Transposase DDE domain - - - - - - - - - - - - DDE_Tnp_1 k59_7982_1 582744.Msip34_1038 6.1e-31 115.0 COG1225@1|root,COG1225@2|Bacteria,1RH4P@1224|Proteobacteria,2VT1P@28216|Betaproteobacteria,2KMST@206350|Nitrosomonadales 206350|Nitrosomonadales O PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen - - 1.11.1.15 ko:K03564 - - - - ko00000,ko01000 - - - AhpC-TSA k59_7982_2 1122603.ATVI01000001_gene1892 3.15e-79 246.0 COG3825@1|root,COG3825@2|Bacteria,1MUAJ@1224|Proteobacteria,1RMRY@1236|Gammaproteobacteria,1X4SK@135614|Xanthomonadales 135614|Xanthomonadales S protein conserved in bacteria - - - ko:K09989 - - - - ko00000 - - - VWA_CoxE k59_1476868_1 330214.NIDE1201 3.37e-102 310.0 COG1249@1|root,COG1249@2|Bacteria,3J0IM@40117|Nitrospirae 40117|Nitrospirae C Evidence 2a Function of homologous gene experimentally demonstrated in an other organism - - 1.6.1.1,1.8.1.4 ko:K00322,ko:K00382 ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko00760,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map00760,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00036,M00307,M00532 R00112,R00209,R01221,R01698,R03815,R07618,R08549 RC00001,RC00004,RC00022,RC00583,RC02742,RC02833,RC02834 br01601,ko00000,ko00001,ko00002,ko01000,ko04147 - - - Pyr_redox_2,Pyr_redox_dim k59_1363717_1 197221.22295265 3.61e-27 118.0 COG0515@1|root,COG3170@1|root,COG4252@1|root,COG0515@2|Bacteria,COG3170@2|Bacteria,COG4252@2|Bacteria,1FZWQ@1117|Cyanobacteria 1117|Cyanobacteria KLT PFAM Protein kinase domain - - - - - - - - - - - - CHASE2,Pkinase k59_1702200_1 107635.AZUO01000005_gene4229 3.93e-41 145.0 COG0356@1|root,COG0356@2|Bacteria,1MV87@1224|Proteobacteria,2U06M@28211|Alphaproteobacteria,36ZGC@31993|Methylocystaceae 28211|Alphaproteobacteria C ATP synthase A chain - - - ko:K02108 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko03110 3.A.2.1 - - ATP-synt_A k59_1307290_1 421531.IX38_01510 5.38e-17 75.9 COG2318@1|root,COG2318@2|Bacteria,4NQEI@976|Bacteroidetes,1I2T3@117743|Flavobacteriia,3ZS40@59732|Chryseobacterium 976|Bacteroidetes S Protein of unknown function (DUF1572) - - - - - - - - - - - - DUF1572 k59_1307290_2 946077.W5A_04738 3.62e-39 144.0 COG0457@1|root,COG0457@2|Bacteria,4NH87@976|Bacteroidetes,1HZMD@117743|Flavobacteriia 976|Bacteroidetes S Tetratricopeptide repeat - - - - - - - - - - - - TPR_8 k59_1758885_1 1123270.ATUR01000002_gene2739 8.3e-23 101.0 COG4544@1|root,COG4544@2|Bacteria,1MY56@1224|Proteobacteria,2U9Y7@28211|Alphaproteobacteria,2K4KW@204457|Sphingomonadales 204457|Sphingomonadales S SOS response - - - ko:K14160 - - - - ko00000,ko03400 - - - - k59_1476879_1 1122137.AQXF01000002_gene25 1.12e-39 145.0 COG3206@1|root,COG3206@2|Bacteria,1MVBX@1224|Proteobacteria,2U1E2@28211|Alphaproteobacteria 28211|Alphaproteobacteria M Chain-length determining protein - - - - - - - - - - - - GNVR,Wzz k59_177013_1 1131814.JAFO01000001_gene1546 7.56e-64 210.0 COG1062@1|root,COG1062@2|Bacteria,1MUK4@1224|Proteobacteria,2TU1G@28211|Alphaproteobacteria,3F0F7@335928|Xanthobacteraceae 28211|Alphaproteobacteria C Alcohol dehydrogenase GroES-like domain - - 1.1.1.1 ko:K00001 ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220 - R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310 RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273 ko00000,ko00001,ko01000 - - - ADH_N,ADH_zinc_N k59_8008_1 1122137.AQXF01000006_gene907 2.87e-92 276.0 COG2199@1|root,COG3706@2|Bacteria,1RAHM@1224|Proteobacteria,2U5VI@28211|Alphaproteobacteria 28211|Alphaproteobacteria T Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - - - - - - - - - - Hpt,Response_reg k59_8008_2 1122137.AQXF01000002_gene639 5.43e-134 404.0 COG0557@1|root,COG0557@2|Bacteria,1MUS6@1224|Proteobacteria,2TRC1@28211|Alphaproteobacteria 28211|Alphaproteobacteria J 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs rnr GO:0000175,GO:0003674,GO:0003724,GO:0003824,GO:0004386,GO:0004518,GO:0004527,GO:0004532,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008408,GO:0008997,GO:0009056,GO:0009057,GO:0009266,GO:0009409,GO:0009628,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010605,GO:0010629,GO:0016070,GO:0016071,GO:0016462,GO:0016787,GO:0016788,GO:0016796,GO:0016817,GO:0016818,GO:0016896,GO:0017111,GO:0019222,GO:0019439,GO:0034458,GO:0034470,GO:0034641,GO:0034655,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0050896,GO:0060255,GO:0065007,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0140098,GO:1901360,GO:1901361,GO:1901575 - ko:K12573 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03016,ko03019 - - - RNB,S1 k59_233446_1 323848.Nmul_A0002 4.72e-46 160.0 COG0592@1|root,COG0592@2|Bacteria,1MVD9@1224|Proteobacteria,2VH9B@28216|Betaproteobacteria,371UF@32003|Nitrosomonadales 28216|Betaproteobacteria L Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria dnaN - 2.7.7.7 ko:K02338 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_beta,DNA_pol3_beta_2,DNA_pol3_beta_3 k59_1758894_1 1144305.PMI02_02359 9.46e-76 237.0 COG0111@1|root,COG0111@2|Bacteria,1MW1U@1224|Proteobacteria,2VFXC@28211|Alphaproteobacteria,2KE0C@204457|Sphingomonadales 204457|Sphingomonadales EH D-isomer specific 2-hydroxyacid dehydrogenase - - - - - - - - - - - - 2-Hacid_dh,2-Hacid_dh_C k59_1081004_1 1229780.BN381_290030 2.65e-54 183.0 COG2230@1|root,COG2230@2|Bacteria,2IA12@201174|Actinobacteria 201174|Actinobacteria M Mycolic acid cyclopropane synthetase - - 2.1.1.79 ko:K00574 - - - - ko00000,ko01000 - - - CMAS k59_572331_1 379066.GAU_0008 1.67e-21 94.7 COG0515@1|root,COG0515@2|Bacteria,1ZT9E@142182|Gemmatimonadetes 142182|Gemmatimonadetes KLT Protein kinase domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase k59_1137427_1 1121937.AUHJ01000004_gene1050 1.76e-27 115.0 2DUYH@1|root,33T16@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_967854_1 937777.Deipe_3233 7.39e-17 79.7 COG0579@1|root,COG0579@2|Bacteria,1WMNW@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus S FAD dependent oxidoreductase - - - ko:K15736 - - - - ko00000,ko01000 - - - DAO k59_967854_2 862751.SACTE_6266 4.82e-05 48.9 COG3967@1|root,COG3967@2|Bacteria,2GP7V@201174|Actinobacteria 201174|Actinobacteria M Belongs to the short-chain dehydrogenases reductases (SDR) family - - - - - - - - - - - - adh_short k59_233470_1 95619.PM1_0219080 4.83e-74 232.0 COG0031@1|root,COG0031@2|Bacteria,1MUBE@1224|Proteobacteria,1RN6J@1236|Gammaproteobacteria 1236|Gammaproteobacteria E Belongs to the cysteine synthase cystathionine beta- synthase family cysK GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004124,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009333,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0016829,GO:0016846,GO:0019344,GO:0019752,GO:0019842,GO:0030170,GO:0032991,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0080146,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494,GO:1990234 2.5.1.47 ko:K01738 ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230 M00021 R00897,R03601,R04859 RC00020,RC02814,RC02821 ko00000,ko00001,ko00002,ko01000 - - iAF1260.b2414,iAPECO1_1312.APECO1_4131,iB21_1397.B21_02275,iBWG_1329.BWG_2176,iE2348C_1286.E2348C_2600,iEC042_1314.EC042_2623,iEC55989_1330.EC55989_2704,iECABU_c1320.ECABU_c27350,iECBD_1354.ECBD_1267,iECB_1328.ECB_02314,iECDH10B_1368.ECDH10B_2579,iECDH1ME8569_1439.ECDH1ME8569_2348,iECD_1391.ECD_02314,iECED1_1282.ECED1_2858,iECH74115_1262.ECH74115_3645,iECIAI1_1343.ECIAI1_2472,iECNA114_1301.ECNA114_2491,iECO103_1326.ECO103_2933,iECO111_1330.ECO111_3144,iECO26_1355.ECO26_3467,iECOK1_1307.ECOK1_2731,iECP_1309.ECP_2438,iECS88_1305.ECS88_2604,iECSE_1348.ECSE_2705,iECSF_1327.ECSF_2278,iECSP_1301.ECSP_3362,iECUMN_1333.ECUMN_2736,iECW_1372.ECW_m2643,iECs_1301.ECs3286,iEKO11_1354.EKO11_1314,iETEC_1333.ETEC_2527,iEcDH1_1363.EcDH1_1247,iEcHS_1320.EcHS_A2549,iEcSMS35_1347.EcSMS35_2569,iEcolC_1368.EcolC_1264,iG2583_1286.G2583_2946,iJO1366.b2414,iJR904.b2414,iLF82_1304.LF82_0418,iNRG857_1313.NRG857_12105,iSSON_1240.SSON_2503,iSbBS512_1146.SbBS512_E2766,iUMN146_1321.UM146_04550,iUMNK88_1353.UMNK88_3016,iUTI89_1310.UTI89_C2747,iWFL_1372.ECW_m2643,iY75_1357.Y75_RS12650,iZ_1308.Z3680 PALP k59_1081028_1 1198452.Jab_2c29810 1.15e-46 162.0 COG1018@1|root,COG1018@2|Bacteria,1MY2Q@1224|Proteobacteria,2VKK1@28216|Betaproteobacteria,4736I@75682|Oxalobacteraceae 28216|Betaproteobacteria C Oxidoreductase FAD-binding domain paaE - - ko:K02613 ko00360,ko01120,map00360,map01120 - R09838 RC02690 ko00000,ko00001 - - - FAD_binding_6,Fer2,NAD_binding_1 k59_1081028_2 319236.JCM19294_1861 2.63e-12 64.3 COG2151@1|root,COG2151@2|Bacteria,4NMS0@976|Bacteroidetes,1HXIB@117743|Flavobacteriia,3HJDW@363408|Nonlabens 976|Bacteroidetes S Pfam:DUF59 paaD - - ko:K02612 ko00360,ko01120,map00360,map01120 - R09838 RC02690 ko00000,ko00001 - - - FeS_assembly_P k59_1025330_1 864073.HFRIS_020140 1.05e-189 535.0 COG2021@1|root,COG2021@2|Bacteria,1MVJV@1224|Proteobacteria,2VHU9@28216|Betaproteobacteria,473B8@75682|Oxalobacteraceae 28216|Betaproteobacteria E Transfers a succinyl group from succinyl-CoA to L- homoserine, forming succinyl-L-homoserine metXS - 2.3.1.31 ko:K00641 ko00270,ko01100,ko01130,map00270,map01100,map01130 - R01776 RC00004,RC00041 ko00000,ko00001,ko01000 - - - Abhydrolase_1 k59_1534281_1 522306.CAP2UW1_0860 4.58e-15 78.2 2BUI5@1|root,32PUE@2|Bacteria,1RHFT@1224|Proteobacteria,2VT0W@28216|Betaproteobacteria 28216|Betaproteobacteria S PEP-CTERM motif - - - - - - - - - - - - VPEP k59_1138503_1 1229909.NSED_03335 2.15e-50 167.0 COG1938@1|root,arCOG00347@2157|Archaea,41T2Y@651137|Thaumarchaeota 651137|Thaumarchaeota S PAC2 family - - - ko:K06869 - - - - ko00000 - - - PAC2 k59_1590221_1 1453501.JELR01000001_gene3106 2.46e-144 431.0 COG4773@1|root,COG4773@2|Bacteria,1QTXJ@1224|Proteobacteria,1T2NX@1236|Gammaproteobacteria,46D3S@72275|Alteromonadaceae 1236|Gammaproteobacteria P TonB dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_1026386_1 1121403.AUCV01000038_gene4230 6.31e-102 300.0 COG0356@1|root,COG0356@2|Bacteria,1RBEV@1224|Proteobacteria 1224|Proteobacteria C it plays a direct role in the translocation of protons across the membrane - - - ko:K02108 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko03110 3.A.2.1 - - ATP-synt_A k59_1478164_1 713586.KB900536_gene1749 1.43e-63 199.0 COG1898@1|root,COG1898@2|Bacteria,1R9YD@1224|Proteobacteria,1S245@1236|Gammaproteobacteria,1WVXE@135613|Chromatiales 135613|Chromatiales M Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose - - 5.1.3.13 ko:K01790 ko00521,ko00523,ko01130,map00521,map00523,map01130 M00793 R06514 RC01531 ko00000,ko00001,ko00002,ko01000 - - - dTDP_sugar_isom k59_968943_1 94122.Shewana3_0919 4.09e-63 201.0 28KDQ@1|root,2ZA05@2|Bacteria,1QE8C@1224|Proteobacteria,1S0JF@1236|Gammaproteobacteria,2QDSI@267890|Shewanellaceae 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_968943_2 62928.azo2383 4.65e-49 162.0 COG4659@1|root,COG4659@2|Bacteria,1RFGW@1224|Proteobacteria,2VTI7@28216|Betaproteobacteria 28216|Betaproteobacteria C PFAM FMN-binding domain protein - - - - - - - - - - - - FMN_bind k59_460694_1 1286631.X805_38580 1.97e-40 140.0 COG0614@1|root,COG0614@2|Bacteria,1PKNF@1224|Proteobacteria,2VMK5@28216|Betaproteobacteria,1KJ2A@119065|unclassified Burkholderiales 28216|Betaproteobacteria P Periplasmic binding protein - - - ko:K02016 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko02000 3.A.1.14 - - Peripla_BP_2 k59_460694_2 1117647.M5M_08490 1.11e-14 73.9 COG1804@1|root,COG1804@2|Bacteria,1MW1H@1224|Proteobacteria,1RN9B@1236|Gammaproteobacteria,1J4MI@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C acyl-CoA transferases carnitine dehydratase - - 5.1.99.4 ko:K01796 ko00120,ko01100,ko04146,map00120,map01100,map04146 M00104 R08734,R08739 RC02345 ko00000,ko00001,ko00002,ko01000 - - - CoA_transf_3 k59_1647430_1 580332.Slit_2584 1.05e-50 170.0 COG2836@1|root,COG2836@2|Bacteria,1RIGJ@1224|Proteobacteria,2VINE@28216|Betaproteobacteria,44VB0@713636|Nitrosomonadales 28216|Betaproteobacteria S Cytochrome C biogenesis protein transmembrane region - - - ko:K09792 - - - - ko00000 - - - DsbD_2 k59_1647433_1 290318.Cvib_0168 5.79e-42 156.0 COG4198@1|root,COG4198@2|Bacteria,1FDIR@1090|Chlorobi 1090|Chlorobi S PFAM conserved - - - - - - - - - - - - DUF1015 k59_178171_1 1187851.A33M_3618 2.92e-37 137.0 COG0391@1|root,COG0391@2|Bacteria,1NK78@1224|Proteobacteria,2TUUA@28211|Alphaproteobacteria 28211|Alphaproteobacteria S LPPG Fo 2-phospho-L-lactate transferase cofD - 2.7.8.28 ko:K11212 ko00680,ko01120,map00680,map01120 M00378 R09398 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - UPF0052 k59_65990_1 243233.MCA0234 6.09e-72 230.0 COG2710@1|root,COG2710@2|Bacteria,1MWSX@1224|Proteobacteria,1RPBI@1236|Gammaproteobacteria,1XEFD@135618|Methylococcales 135618|Methylococcales C Belongs to the NifD NifK NifE NifN family nifN - - ko:K02592 - - - - ko00000 - - - Oxidored_nitro k59_743337_1 1125973.JNLC01000001_gene149 1.4e-25 111.0 COG0399@1|root,COG0399@2|Bacteria,1MUPN@1224|Proteobacteria,2U51A@28211|Alphaproteobacteria 28211|Alphaproteobacteria M Belongs to the DegT DnrJ EryC1 family - - - - - - - - - - - - DegT_DnrJ_EryC1,Pyr_redox_2 k59_630105_1 1459636.NTE_01313 1.96e-10 67.0 arCOG08812@1|root,arCOG08812@2157|Archaea,41SXB@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_743342_3 436308.Nmar_0038 2.94e-111 322.0 COG0302@1|root,arCOG04542@2157|Archaea,41SGC@651137|Thaumarchaeota 651137|Thaumarchaeota H GTP cyclohydrolase I folE - 3.5.4.16 ko:K01495 ko00790,ko01100,map00790,map01100 M00126,M00841,M00842,M00843 R00428,R04639,R05046,R05048 RC00263,RC00294,RC00323,RC00945,RC01188 ko00000,ko00001,ko00002,ko01000 - - - GTP_cyclohydroI k59_686537_1 1167006.UWK_00731 4.23e-08 59.7 COG1629@1|root,COG4771@2|Bacteria,1MUC1@1224|Proteobacteria,42PWS@68525|delta/epsilon subdivisions,2WKI5@28221|Deltaproteobacteria,2MJ8W@213118|Desulfobacterales 28221|Deltaproteobacteria P TonB dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_800347_1 177437.HRM2_39480 9.07e-05 48.1 COG3385@1|root,COG3385@2|Bacteria,1RM2A@1224|Proteobacteria,42WE3@68525|delta/epsilon subdivisions,2X6QW@28221|Deltaproteobacteria,2MN97@213118|Desulfobacterales 28221|Deltaproteobacteria L Transposase DDE domain group 1 - - - - - - - - - - - - DDE_Tnp_1_4 k59_686539_1 393595.ABO_0909 3.3e-93 282.0 COG0451@1|root,COG0451@2|Bacteria,1MU7J@1224|Proteobacteria,1RPTA@1236|Gammaproteobacteria,1XI3X@135619|Oceanospirillales 135619|Oceanospirillales M Male sterility protein - - 5.1.3.7 ko:K02473 ko00520,ko01100,map00520,map01100 - R00418 RC00289 ko00000,ko00001,ko01000 - - - Epimerase k59_686540_1 1229909.NSED_08090 2.26e-27 104.0 COG1522@1|root,arCOG01117@2157|Archaea 2157|Archaea K COG1522 Transcriptional regulators - - - - - - - - - - - - AsnC_trans_reg k59_968978_1 158500.BV97_00751 1.17e-87 270.0 2CIPC@1|root,2Z9HB@2|Bacteria,1R3W8@1224|Proteobacteria,2TST7@28211|Alphaproteobacteria,2K56C@204457|Sphingomonadales 204457|Sphingomonadales S Glycosyltransferase family 87 - - - - - - - - - - - - GT87 k59_968978_2 1096930.L284_03185 1.06e-71 222.0 COG0714@1|root,COG0714@2|Bacteria,1MV5I@1224|Proteobacteria,2TRI8@28211|Alphaproteobacteria,2JZXF@204457|Sphingomonadales 204457|Sphingomonadales S ATPase AAA - - - - - - - - - - - - AAA k59_348262_1 84531.JMTZ01000024_gene4041 4.02e-19 87.8 COG3541@1|root,COG3541@2|Bacteria,1MYFT@1224|Proteobacteria,1RY9F@1236|Gammaproteobacteria,1X6IN@135614|Xanthomonadales 135614|Xanthomonadales S Predicted nucleotidyltransferase - - - ko:K07074 - - - - ko00000 - - - Nuc-transf k59_1534368_1 1056820.KB900647_gene2977 1.24e-59 202.0 COG4124@1|root,COG5297@1|root,COG4124@2|Bacteria,COG5297@2|Bacteria,1Q17Q@1224|Proteobacteria,1RZFV@1236|Gammaproteobacteria,2PMZW@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria G Glycosyl hydrolase family 26 - - 3.2.1.78 ko:K01218 ko00051,ko02024,map00051,map02024 - R01332 RC00467 ko00000,ko00001,ko01000 - GH26 - CBM_10,CBM_2,Glyco_hydro_26 k59_122260_1 1120934.KB894404_gene898 1.24e-34 134.0 COG1064@1|root,COG1064@2|Bacteria,2GNVQ@201174|Actinobacteria,4E0VQ@85010|Pseudonocardiales 201174|Actinobacteria S alcohol dehydrogenase - - 1.1.1.1 ko:K13953 ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220 - R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310 RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273 ko00000,ko00001,ko01000 - - - ADH_N,ADH_zinc_N k59_291901_1 686340.Metal_3742 1.22e-64 202.0 COG1510@1|root,COG1510@2|Bacteria,1RA49@1224|Proteobacteria,1RRGB@1236|Gammaproteobacteria,1XGG9@135618|Methylococcales 135618|Methylococcales K Belongs to the GbsR family - - - - - - - - - - - - - k59_573565_1 1380600.AUYN01000001_gene2425 1.23e-29 108.0 COG0811@1|root,COG0811@2|Bacteria,4NVQH@976|Bacteroidetes,1I40C@117743|Flavobacteriia 976|Bacteroidetes U MotA/TolQ/ExbB proton channel family - - - - - - - - - - - - MotA_ExbB k59_573565_2 1484460.JSWG01000003_gene795 9.39e-75 228.0 2DMRQ@1|root,32T84@2|Bacteria,4NU8C@976|Bacteroidetes,1I2RC@117743|Flavobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_573570_1 357808.RoseRS_0325 5.07e-23 95.1 COG0526@1|root,COG0526@2|Bacteria,2G72F@200795|Chloroflexi,377HE@32061|Chloroflexia 32061|Chloroflexia CO PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen - - - - - - - - - - - - AhpC-TSA k59_1703459_1 573065.Astex_2398 2.97e-48 174.0 COG1629@1|root,COG4771@2|Bacteria,1MXAE@1224|Proteobacteria,2TRQV@28211|Alphaproteobacteria,2KHQ9@204458|Caulobacterales 204458|Caulobacterales P TonB-dependent Receptor Plug Domain - - - - - - - - - - - - Plug k59_856700_1 436308.Nmar_1528 1.29e-15 81.6 arCOG07561@1|root,arCOG07561@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - TSP_3,VWA k59_66023_1 1088721.NSU_0827 2.01e-39 143.0 COG0534@1|root,COG0534@2|Bacteria,1MV6B@1224|Proteobacteria,2TSKZ@28211|Alphaproteobacteria,2K3P8@204457|Sphingomonadales 204457|Sphingomonadales V MATE efflux family protein - - - ko:K03327 - - - - ko00000,ko02000 2.A.66.1 - - MatE k59_856711_1 404380.Gbem_0293 1.18e-17 79.3 COG2885@1|root,COG2885@2|Bacteria,1MZTV@1224|Proteobacteria,42R5H@68525|delta/epsilon subdivisions,2WNZS@28221|Deltaproteobacteria,43UVU@69541|Desulfuromonadales 28221|Deltaproteobacteria M PFAM OmpA MotB domain protein pal - - ko:K03640 - - - - ko00000,ko02000 2.C.1.2 - - OmpA k59_630139_1 498211.CJA_3566 5.45e-82 265.0 COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,1RNJI@1236|Gammaproteobacteria,1FG8D@10|Cellvibrio 1236|Gammaproteobacteria L UvrD-like helicase C-terminal domain uvrD GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006289,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009628,GO:0009987,GO:0015616,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017116,GO:0022607,GO:0031297,GO:0032392,GO:0032508,GO:0033554,GO:0034641,GO:0034645,GO:0042623,GO:0042802,GO:0043142,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0045005,GO:0046483,GO:0050896,GO:0051259,GO:0051260,GO:0051276,GO:0051716,GO:0065003,GO:0070035,GO:0070581,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360,GO:1901576 3.6.4.12 ko:K03657 ko03420,ko03430,map03420,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - UvrD-helicase,UvrD_C k59_743393_2 472175.EL18_02583 3.27e-10 63.5 COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,2TT48@28211|Alphaproteobacteria,43R36@69277|Phyllobacteriaceae 28211|Alphaproteobacteria U transport systems - - - ko:K02033 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1 k59_630148_1 1129374.AJE_07701 1.97e-17 83.2 2E3UE@1|root,32YRS@2|Bacteria,1N75A@1224|Proteobacteria,1S9W5@1236|Gammaproteobacteria,468Q7@72275|Alteromonadaceae 1236|Gammaproteobacteria S Protein of unknown function (DUF2799) - - - - - - - - - - - - DUF2799 k59_1195130_1 1217712.F971_02477 2.49e-59 202.0 COG2271@1|root,COG2271@2|Bacteria,1MWYR@1224|Proteobacteria,1RNBI@1236|Gammaproteobacteria,3NSX3@468|Moraxellaceae 1236|Gammaproteobacteria G Organic Anion Transporter Polypeptide (OATP) family - - - - - - - - - - - - MFS_1 k59_1026464_2 1177179.A11A3_07970 7.38e-38 136.0 COG0226@1|root,COG0226@2|Bacteria,1MUH9@1224|Proteobacteria,1RN9U@1236|Gammaproteobacteria,1XHR0@135619|Oceanospirillales 135619|Oceanospirillales P Phosphate ABC transporter substrate-binding protein - - - ko:K02040 ko02010,ko02020,ko05152,map02010,map02020,map05152 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - PBP_like_2 k59_1427303_2 999549.KI421513_gene745 2.02e-52 178.0 COG0161@1|root,COG0161@2|Bacteria,1MU2N@1224|Proteobacteria,2TQND@28211|Alphaproteobacteria,2808W@191028|Leisingera 28211|Alphaproteobacteria H Aminotransferase class-III - - - - - - - - - - - - Aminotran_3 k59_1710107_1 1545915.JROG01000004_gene2150 4.29e-89 270.0 COG1028@1|root,COG1028@2|Bacteria,1MWGK@1224|Proteobacteria,2TVQ8@28211|Alphaproteobacteria,2K2DN@204457|Sphingomonadales 204457|Sphingomonadales IQ KR domain - - - - - - - - - - - - adh_short_C2 k59_1597152_1 298654.FraEuI1c_6563 6.77e-23 97.1 COG1028@1|root,COG1028@2|Bacteria,2GMQE@201174|Actinobacteria 201174|Actinobacteria IQ Short-chain dehydrogenase reductase sdr - - - - - - - - - - - - adh_short_C2 k59_919125_2 264462.Bd3044 2.4e-38 137.0 COG2036@1|root,COG2036@2|Bacteria,1N3S6@1224|Proteobacteria,42UYX@68525|delta/epsilon subdivisions,2MU6K@213481|Bdellovibrionales,2WQE4@28221|Deltaproteobacteria 213481|Bdellovibrionales B protein heterodimerization activity - - - - - - - - - - - - - k59_355052_1 29540.C481_04691 6.61e-11 68.2 COG2146@1|root,arCOG02852@2157|Archaea,2XUZH@28890|Euryarchaeota,23SZ3@183963|Halobacteria 183963|Halobacteria P COG2146 Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases - - - - - - - - - - - - Rieske,Rieske_2 k59_355052_2 1367847.JCM7686_2842 3.63e-33 124.0 COG2345@1|root,COG2345@2|Bacteria,1RDXT@1224|Proteobacteria,2U1K1@28211|Alphaproteobacteria 28211|Alphaproteobacteria K Transcriptional regulator - - - - - - - - - - - - HTH_11,HTH_5,MarR_2,PadR,Replic_Relax k59_523046_1 1122927.KB895414_gene5046 7.2e-42 157.0 COG3250@1|root,COG3250@2|Bacteria,1TPDC@1239|Firmicutes,4HUM3@91061|Bacilli,26UZS@186822|Paenibacillaceae 91061|Bacilli G Belongs to the glycosyl hydrolase 2 family - - 3.2.1.23 ko:K01190 ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100 - R01105,R01678,R03355,R04783,R06114 RC00049,RC00452 ko00000,ko00001,ko01000 - - - DUF4982,F5_F8_type_C,Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N k59_1257970_1 436308.Nmar_0049 1.38e-70 219.0 COG0175@1|root,arCOG00124@2157|Archaea,41S9Q@651137|Thaumarchaeota 651137|Thaumarchaeota E Phosphoadenosine phosphosulfate reductase family - - 1.8.4.10,1.8.4.8 ko:K00390 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00176 R02021 RC00007,RC02862 ko00000,ko00001,ko00002,ko01000 - - - PAPS_reduct k59_1257970_2 436308.Nmar_0050 7.18e-36 131.0 COG2046@1|root,arCOG04191@2157|Archaea,41SER@651137|Thaumarchaeota 651137|Thaumarchaeota P Belongs to the sulfate adenylyltransferase family sat - 2.7.7.4 ko:K00958 ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130 M00176,M00596 R00529,R04929 RC02809,RC02889 ko00000,ko00001,ko00002,ko01000 - - - ATP-sulfurylase,PUA_2 k59_1710133_1 498211.CJA_1314 1.12e-118 357.0 COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,1RPWS@1236|Gammaproteobacteria,1FGJH@10|Cellvibrio 1236|Gammaproteobacteria S ABC transporter yjjK GO:0003674,GO:0003824,GO:0005488,GO:0006417,GO:0006448,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017148,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0034248,GO:0034249,GO:0043021,GO:0043022,GO:0044877,GO:0045900,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0080090,GO:2000112,GO:2000113 3.6.3.25 ko:K06020 - - - - ko00000,ko01000 - - - ABC_tran,ABC_tran_Xtn k59_72750_1 314287.GB2207_06193 1.15e-54 172.0 COG0198@1|root,COG0198@2|Bacteria,1MZQD@1224|Proteobacteria,1S973@1236|Gammaproteobacteria,1J6C1@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit rplX GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02895 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - KOW,ribosomal_L24 k59_72750_2 498211.CJA_0709 1.64e-47 154.0 COG0093@1|root,COG0093@2|Bacteria,1RCWZ@1224|Proteobacteria,1S3Z3@1236|Gammaproteobacteria,1FH9T@10|Cellvibrio 1236|Gammaproteobacteria J Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome rplN GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070180,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02874 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L14 k59_749546_1 523791.Kkor_1995 1.97e-102 305.0 COG1131@1|root,COG1131@2|Bacteria,1R3XF@1224|Proteobacteria,1S0MM@1236|Gammaproteobacteria 1236|Gammaproteobacteria V abc transporter atp-binding protein nodI - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_1654198_1 926550.CLDAP_14210 3.17e-42 147.0 COG1899@1|root,COG1899@2|Bacteria,2G7R7@200795|Chloroflexi 200795|Chloroflexi O PFAM deoxyhypusine synthase - - 2.5.1.46 ko:K00809 - - - - ko00000,ko01000 - - - DS k59_1766681_1 543728.Vapar_1982 5.99e-140 417.0 COG1523@1|root,COG1523@2|Bacteria,1MU19@1224|Proteobacteria,2VH8E@28216|Betaproteobacteria,4AC1I@80864|Comamonadaceae 28216|Betaproteobacteria G PFAM glycoside hydrolase, family 13 domain protein - - 3.2.1.196,3.2.1.68 ko:K01214,ko:K02438 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R02111,R09995,R11261 - ko00000,ko00001,ko00002,ko01000 - CBM48,GH13 - Alpha-amylase,CBM_48 k59_919157_1 330214.NIDE3341 9.51e-105 313.0 COG0303@1|root,COG0303@2|Bacteria,3J0MX@40117|Nitrospirae 40117|Nitrospirae H Probable molybdopterin binding domain - - 2.10.1.1 ko:K03750 ko00790,ko01100,map00790,map01100 - R09735 RC03462 ko00000,ko00001,ko01000 - - - MoCF_biosynth,MoeA_C,MoeA_N k59_581309_1 95619.PM1_0218075 6.08e-72 226.0 COG1694@1|root,COG3956@2|Bacteria,1MVKM@1224|Proteobacteria,1RNVU@1236|Gammaproteobacteria 1236|Gammaproteobacteria C nucleoside triphosphate pyrophosphohydrolase mazG GO:0003674,GO:0003824,GO:0006139,GO:0006163,GO:0006195,GO:0006203,GO:0006213,GO:0006220,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0007154,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009143,GO:0009144,GO:0009146,GO:0009147,GO:0009149,GO:0009151,GO:0009155,GO:0009164,GO:0009166,GO:0009199,GO:0009200,GO:0009203,GO:0009204,GO:0009208,GO:0009210,GO:0009211,GO:0009213,GO:0009215,GO:0009217,GO:0009218,GO:0009219,GO:0009222,GO:0009223,GO:0009259,GO:0009261,GO:0009262,GO:0009264,GO:0009267,GO:0009394,GO:0009605,GO:0009987,GO:0009991,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0019693,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0042454,GO:0042594,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0046046,GO:0046047,GO:0046051,GO:0046052,GO:0046060,GO:0046061,GO:0046070,GO:0046075,GO:0046076,GO:0046080,GO:0046081,GO:0046131,GO:0046133,GO:0046135,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0050896,GO:0051716,GO:0055086,GO:0071496,GO:0071704,GO:0072521,GO:0072523,GO:0072527,GO:0072529,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1901657,GO:1901658 3.6.1.9 ko:K04765 ko00230,ko00240,ko00760,ko00770,ko01100,map00230,map00240,map00760,map00770,map01100 - R00086,R00087,R00103,R00287,R00426,R00515,R00662,R00720,R03004,R03036,R11323 RC00002 ko00000,ko00001,ko01000 - - iAF1260.b2781,iBWG_1329.BWG_2516,iE2348C_1286.E2348C_3048,iEC55989_1330.EC55989_3056,iECDH10B_1368.ECDH10B_2948,iECDH1ME8569_1439.ECDH1ME8569_2691,iECH74115_1262.ECH74115_4041,iECIAI1_1343.ECIAI1_2889,iECO103_1326.ECO103_3324,iECO111_1330.ECO111_3505,iECO26_1355.ECO26_3851,iECOK1_1307.ECOK1_3155,iECP_1309.ECP_2762,iECSE_1348.ECSE_3039,iECSP_1301.ECSP_3733,iECW_1372.ECW_m2990,iECs_1301.ECs3641,iEKO11_1354.EKO11_0987,iEcDH1_1363.EcDH1_0907,iEcE24377_1341.EcE24377A_3085,iEcHS_1320.EcHS_A2925,iEcolC_1368.EcolC_0931,iG2583_1286.G2583_3433,iJO1366.b2781,iJR904.b2781,iSBO_1134.SBO_2662,iSSON_1240.SSON_2938,iSbBS512_1146.SbBS512_E3092,iUMN146_1321.UM146_02665,iUMNK88_1353.UMNK88_3464,iUTI89_1310.UTI89_C3150,iWFL_1372.ECW_m2990,iY75_1357.Y75_RS14470,iZ_1308.Z4096 MazG k59_1655348_2 436308.Nmar_1351 4.29e-39 134.0 arCOG10581@1|root,arCOG10581@2157|Archaea,41T5S@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_411688_1 551789.ATVJ01000002_gene2998 4.14e-63 214.0 COG4773@1|root,COG4773@2|Bacteria,1QTXJ@1224|Proteobacteria,2UQ22@28211|Alphaproteobacteria,43WUA@69657|Hyphomonadaceae 28211|Alphaproteobacteria P TonB dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_299617_1 1250232.JQNJ01000001_gene3314 4.91e-102 321.0 2DB7A@1|root,2Z7KK@2|Bacteria,4NGC2@976|Bacteroidetes,1HYSC@117743|Flavobacteriia 976|Bacteroidetes S Glycosyl hydrolase family 115 - - - - - - - - - - - - Glyco_hydro_115,Glyco_hydro_67N k59_186410_1 498211.CJA_3207 2.93e-89 278.0 COG0171@1|root,COG0388@1|root,COG0171@2|Bacteria,COG0388@2|Bacteria,1MU9U@1224|Proteobacteria,1RNKA@1236|Gammaproteobacteria,1FGTG@10|Cellvibrio 1236|Gammaproteobacteria H Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source nadE - 6.3.1.5,6.3.5.1 ko:K01916,ko:K01950 ko00760,ko01100,map00760,map01100 M00115 R00189,R00257 RC00010,RC00100 ko00000,ko00001,ko00002,ko01000 - - - CN_hydrolase,NAD_synthase k59_186413_1 768670.Calni_0405 5.93e-21 91.3 COG1469@1|root,COG1469@2|Bacteria,2GES6@200930|Deferribacteres 200930|Deferribacteres S Converts GTP to 7,8-dihydroneopterin triphosphate folE2 - 3.5.4.16 ko:K09007 ko00790,ko01100,map00790,map01100 M00126 R00428,R04639,R05046,R05048 RC00263,RC00294,RC00323,RC00945,RC01188 ko00000,ko00001,ko00002,ko01000 - - - GCHY-1 k59_1034311_1 436308.Nmar_0259 1.22e-83 248.0 COG2009@1|root,arCOG02244@2157|Archaea,41SKZ@651137|Thaumarchaeota 651137|Thaumarchaeota C Succinate dehydrogenase/Fumarate reductase transmembrane subunit - - - ko:K00241 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00149,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002 - - - Sdh_cyt k59_1372907_1 1122137.AQXF01000001_gene2960 4.49e-106 335.0 COG2887@1|root,COG3893@1|root,COG2887@2|Bacteria,COG3893@2|Bacteria,1MY2G@1224|Proteobacteria,2TS74@28211|Alphaproteobacteria 28211|Alphaproteobacteria L double-strand break repair protein AddB addB - 3.6.4.12 ko:K16899 - - - - ko00000,ko01000,ko03400 - - - PDDEXK_1 k59_1711223_1 998674.ATTE01000001_gene1658 7.86e-12 68.2 28HYC@1|root,2Z83T@2|Bacteria,1QEBM@1224|Proteobacteria,1RRCK@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_1202987_1 305900.GV64_01070 4.62e-89 276.0 COG1207@1|root,COG1207@2|Bacteria,1MUPH@1224|Proteobacteria,1RNKE@1236|Gammaproteobacteria,1XHJE@135619|Oceanospirillales 135619|Oceanospirillales M Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain glmU - 2.3.1.157,2.7.7.23 ko:K04042 ko00520,ko01100,ko01130,map00520,map01100,map01130 M00362 R00416,R05332 RC00002,RC00004,RC00166 ko00000,ko00001,ko00002,ko01000 - - - Hexapep,NTP_transf_3 k59_1372916_1 1123228.AUIH01000006_gene2310 3.59e-09 62.0 COG0477@1|root,COG2814@2|Bacteria,1QTX0@1224|Proteobacteria,1T23I@1236|Gammaproteobacteria,1XQZC@135619|Oceanospirillales 135619|Oceanospirillales EGP Transmembrane secretion effector - - - - - - - - - - - - MFS_3 k59_1372916_2 926566.Terro_0568 1.02e-12 66.6 2DBN7@1|root,2ZA2Y@2|Bacteria,3Y62R@57723|Acidobacteria,2JKP9@204432|Acidobacteriia 204432|Acidobacteriia S Domain of unknown function (DUF4159) - - - - - - - - - - - - DUF4159 k59_807731_1 331869.BAL199_25369 2.24e-34 132.0 COG0544@1|root,COG0544@2|Bacteria,1MUJP@1224|Proteobacteria,2TS8W@28211|Alphaproteobacteria,4BP73@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria D Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase tig GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - ko:K03545 - - - - ko00000 - - - FKBP_C,Trigger_C,Trigger_N k59_356252_1 1449353.JQMQ01000005_gene1915 2.92e-66 228.0 COG1674@1|root,COG1674@2|Bacteria,2GK3T@201174|Actinobacteria,2NFYU@228398|Streptacidiphilus 201174|Actinobacteria D Ftsk_gamma ftsK GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0030312,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944 - ko:K03466 - - - - ko00000,ko03036 3.A.12 - - FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma k59_186435_2 1206741.BAFX01000064_gene5058 1.19e-64 226.0 COG0178@1|root,COG0178@2|Bacteria,2GJUV@201174|Actinobacteria,4FWNE@85025|Nocardiaceae 201174|Actinobacteria L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate uvrA GO:0000018,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006950,GO:0006974,GO:0008150,GO:0009892,GO:0009987,GO:0010605,GO:0016020,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031324,GO:0033554,GO:0044424,GO:0044444,GO:0044464,GO:0045910,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051053,GO:0051171,GO:0051172,GO:0051716,GO:0060255,GO:0060542,GO:0060543,GO:0065007,GO:0071944,GO:0080090 - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - ABC_tran k59_242224_1 392499.Swit_1890 6.71e-43 152.0 COG0524@1|root,COG0524@2|Bacteria,1MVG2@1224|Proteobacteria,2TSDV@28211|Alphaproteobacteria,2K37P@204457|Sphingomonadales 204457|Sphingomonadales G 2-dehydro-3-deoxygluconokinase kdgK - 2.7.1.45 ko:K00874 ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200 M00061,M00308,M00631 R01541 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - PfkB k59_1203014_1 1088721.NSU_1289 1.67e-79 246.0 COG0489@1|root,COG0489@2|Bacteria,1MU7R@1224|Proteobacteria,2TRDM@28211|Alphaproteobacteria,2K1RH@204457|Sphingomonadales 204457|Sphingomonadales D Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP - - - ko:K03593 - - - - ko00000,ko03029,ko03036 - - - ParA k59_864734_1 1122137.AQXF01000002_gene33 1.06e-90 285.0 COG0367@1|root,COG0367@2|Bacteria,1MW4E@1224|Proteobacteria,2TSCY@28211|Alphaproteobacteria 28211|Alphaproteobacteria E asparagine synthase asnB - 6.3.5.4 ko:K01953 ko00250,ko01100,ko01110,map00250,map01100,map01110 - R00578 RC00010 ko00000,ko00001,ko01000,ko01002 - - - Asn_synthase,GATase_7 k59_411726_1 324602.Caur_2245 6.71e-10 65.1 COG0419@1|root,COG0419@2|Bacteria,2G682@200795|Chloroflexi,375BN@32061|Chloroflexia 32061|Chloroflexia L PFAM SMC domain protein - - - ko:K03546 - - - - ko00000,ko03400 - - - AAA_23,Rad50_zn_hook,SbcCD_C k59_1767763_1 247634.GPB2148_1625 4.93e-81 247.0 COG3971@1|root,COG3971@2|Bacteria,1MVVV@1224|Proteobacteria,1RMZ4@1236|Gammaproteobacteria,1J54I@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria Q 2-keto-4-pentenoate hydratase - - 4.2.1.132,4.2.1.80 ko:K18364 ko00362,ko00621,ko00622,ko01100,ko01120,ko01220,map00362,map00621,map00622,map01100,map01120,map01220 M00569 R02601,R05864 RC00750,RC02676 br01602,ko00000,ko00001,ko00002,ko01000 - - - FAA_hydrolase k59_1542040_1 680198.SCAB_45351 6.64e-81 259.0 COG1012@1|root,COG1012@2|Bacteria,2GNJJ@201174|Actinobacteria 201174|Actinobacteria C Aldehyde dehydrogenase paaZ - - - - - - - - - - - Aldedh k59_129770_1 1283300.ATXB01000001_gene1465 1.77e-55 194.0 COG0744@1|root,COG0744@2|Bacteria,1QTST@1224|Proteobacteria,1RNHV@1236|Gammaproteobacteria,1XE8F@135618|Methylococcales 135618|Methylococcales M Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits) - - 2.4.1.129,3.4.16.4 ko:K05365 ko00550,map00550 - R04519 RC00005,RC00049 ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 - Transgly,Transpeptidase,UB2H k59_637857_1 1121428.DESHY_70038___1 9.06e-69 223.0 COG0064@1|root,COG0064@2|Bacteria,1TPG3@1239|Firmicutes,247MS@186801|Clostridia,260XG@186807|Peptococcaceae 186801|Clostridia J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) gatB - 6.3.5.6,6.3.5.7 ko:K02434 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - GatB_N,GatB_Yqey k59_581390_1 1415778.JQMM01000001_gene703 2.7e-71 237.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1J4C2@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T signal transduction protein containing a membrane domain, an EAL and a GGDEF domain - - - - - - - - - - - - EAL,GGDEF,PAS,PAS_3,PAS_4,PAS_9 k59_750647_1 1121937.AUHJ01000010_gene1697 5.68e-11 67.4 COG3137@1|root,COG3137@2|Bacteria,1RHDT@1224|Proteobacteria,1SIHP@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Protein of unknown function, DUF481 - - - - - - - - - - - - DUF481 k59_750647_2 1265313.HRUBRA_00703 1.04e-17 82.8 COG0834@1|root,COG0834@2|Bacteria,1MWDK@1224|Proteobacteria,1RZ89@1236|Gammaproteobacteria,1JBR6@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria ET Bacterial periplasmic substrate-binding proteins - - - ko:K02030 - M00236 - - ko00000,ko00002,ko02000 3.A.1.3 - - SBP_bac_3 k59_694329_1 314254.OA2633_12785 3.63e-59 190.0 COG0101@1|root,COG0101@2|Bacteria,1MUYI@1224|Proteobacteria,2TR57@28211|Alphaproteobacteria,43X0F@69657|Hyphomonadaceae 28211|Alphaproteobacteria J Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs truA GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016853,GO:0016866,GO:0031119,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360 5.4.99.12 ko:K06173 - - - - ko00000,ko01000,ko03016 - - - PseudoU_synth_1 k59_694329_2 1280950.HJO_13151 3.98e-22 90.9 COG3153@1|root,COG3153@2|Bacteria,1RA42@1224|Proteobacteria,2UDUB@28211|Alphaproteobacteria,43YPJ@69657|Hyphomonadaceae 28211|Alphaproteobacteria S Acetyltransferase (GNAT) domain - - - ko:K03824 - - - - ko00000,ko01000 - - - Acetyltransf_1,Acetyltransf_9 k59_411745_1 857087.Metme_2457 1.07e-47 159.0 COG1733@1|root,COG1733@2|Bacteria,1PGWN@1224|Proteobacteria,1SXVP@1236|Gammaproteobacteria,1XGTB@135618|Methylococcales 135618|Methylococcales K HxlR-like helix-turn-helix - - - - - - - - - - - - HxlR k59_1428469_2 1522072.IL54_1158 2.79e-48 162.0 COG1024@1|root,COG1024@2|Bacteria,1Q51H@1224|Proteobacteria,2TUPH@28211|Alphaproteobacteria,2K2FJ@204457|Sphingomonadales 204457|Sphingomonadales I Enoyl-CoA hydratase isomerase - - 4.2.1.17 ko:K01692 ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212 M00032,M00087 R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093 RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 - - - ECH_1 k59_581401_1 1131266.ARWQ01000006_gene260 9.74e-08 52.8 COG2084@1|root,arCOG00247@2157|Archaea,41SI2@651137|Thaumarchaeota 651137|Thaumarchaeota I NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase - - 1.1.1.31 ko:K00020 ko00280,ko01100,map00280,map01100 - R05066 RC00099 ko00000,ko00001,ko01000 - - - NAD_binding_11,NAD_binding_2 k59_299681_1 566466.NOR53_200 2.02e-69 211.0 COG0203@1|root,COG0203@2|Bacteria,1RCWN@1224|Proteobacteria,1S3QK@1236|Gammaproteobacteria,1J60B@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Ribosomal protein L17 rplQ GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02879 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L17 k59_581419_1 1401328.P856_745 3.37e-32 127.0 COG1364@1|root,COG1364@2|Bacteria,1MU0T@1224|Proteobacteria,2TS98@28211|Alphaproteobacteria,2JPX5@204441|Rhodospirillales 204441|Rhodospirillales E Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate argJ - 2.3.1.1,2.3.1.35 ko:K00620 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028 R00259,R02282 RC00004,RC00064 ko00000,ko00001,ko00002,ko01000 - - - ArgJ k59_411765_1 314278.NB231_15783 1.52e-50 169.0 COG0811@1|root,COG0811@2|Bacteria,1NCWW@1224|Proteobacteria,1RMD4@1236|Gammaproteobacteria,1WWA0@135613|Chromatiales 135613|Chromatiales U PFAM MotA TolQ ExbB proton channel - - - ko:K03562 ko01120,map01120 - - - ko00000,ko02000 1.A.30.2.2 - - MotA_ExbB k59_637903_1 631362.Thi970DRAFT_01284 9.91e-26 98.6 COG0139@1|root,COG0139@2|Bacteria,1MW67@1224|Proteobacteria,1RMV4@1236|Gammaproteobacteria,1WYNT@135613|Chromatiales 135613|Chromatiales E Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP hisI - 3.5.4.19 ko:K01496 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04037 RC01055 ko00000,ko00001,ko00002,ko01000 - - - PRA-CH,PRA-PH k59_637903_2 1210884.HG799465_gene12202 1.15e-37 135.0 COG0040@1|root,COG0040@2|Bacteria,2IXEV@203682|Planctomycetes 203682|Planctomycetes F ATP phosphoribosyltransferase hisG GO:0000105,GO:0003674,GO:0003824,GO:0003879,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.17 ko:K00765 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R01071 RC02819,RC03200 ko00000,ko00001,ko00002,ko01000 - - - HisG,HisG_C k59_1655433_1 330214.NIDE3560 2.37e-108 323.0 COG1894@1|root,COG1894@2|Bacteria,3J0WA@40117|Nitrospirae 40117|Nitrospirae C NADH-ubiquinone oxidoreductase-F iron-sulfur binding region - - 1.6.5.3 ko:K00335 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_51K,NADH_4Fe-4S,SLBB k59_750679_1 65489.OBART02G17860.1 1.1e-26 112.0 COG1028@1|root,KOG1205@2759|Eukaryota,37IE5@33090|Viridiplantae,3GCVE@35493|Streptophyta,3M3JI@4447|Liliopsida,3IGII@38820|Poales 35493|Streptophyta Q Enoyl-(Acyl carrier protein) reductase - GO:0005575,GO:0005622,GO:0005623,GO:0005811,GO:0016020,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044424,GO:0044464 1.1.1.146 ko:K22418 - - - - ko00000,ko01000 - - - adh_short k59_1203055_1 247634.GPB2148_758 1.95e-41 145.0 COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,1RMM4@1236|Gammaproteobacteria,1J4UX@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria V COG1131 ABC-type multidrug transport system, ATPase component ybhF - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_1203055_2 1249627.D779_3649 3.76e-22 94.4 COG1566@1|root,COG1566@2|Bacteria,1RBK7@1224|Proteobacteria,1S241@1236|Gammaproteobacteria,1X2HT@135613|Chromatiales 135613|Chromatiales V HlyD family secretion protein - - - ko:K01993 - - - - ko00000 - - - HlyD_3 k59_976015_1 153948.NAL212_0468 4.32e-18 88.6 COG0471@1|root,COG0471@2|Bacteria,1MUSA@1224|Proteobacteria,2VJ9R@28216|Betaproteobacteria,372ES@32003|Nitrosomonadales 28216|Betaproteobacteria P TIGRFAM Sodium sulphate symporter - - - ko:K11106,ko:K14445 - - - - ko00000,ko02000 2.A.47.1,2.A.47.3.3 - - Na_sulph_symp k59_1203063_2 395019.Bmul_1142 5.03e-36 128.0 COG0394@1|root,COG0394@2|Bacteria,1RH90@1224|Proteobacteria,2VSKW@28216|Betaproteobacteria,1K57G@119060|Burkholderiaceae 28216|Betaproteobacteria T Low molecular weight phosphotyrosine protein phosphatase ptpA GO:0000271,GO:0003674,GO:0003824,GO:0004721,GO:0004725,GO:0005975,GO:0005976,GO:0006464,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009242,GO:0009987,GO:0016051,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019538,GO:0033692,GO:0034637,GO:0034645,GO:0035335,GO:0036211,GO:0042578,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044267,GO:0046377,GO:0071704,GO:0140096,GO:1901135,GO:1901137,GO:1901564,GO:1901576 3.1.3.48 ko:K01104 - - - - ko00000,ko01000 - - - LMWPc k59_1316214_1 314282.PCNPT3_06580 4.45e-61 209.0 COG0793@1|root,COG0793@2|Bacteria,1MU39@1224|Proteobacteria,1RMSR@1236|Gammaproteobacteria,2QHSF@267894|Psychromonadaceae 1236|Gammaproteobacteria M Belongs to the peptidase S41A family prc GO:0003674,GO:0003824,GO:0004175,GO:0005575,GO:0005623,GO:0005886,GO:0006508,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0016020,GO:0016787,GO:0019538,GO:0023052,GO:0030163,GO:0030288,GO:0030313,GO:0031975,GO:0042221,GO:0042597,GO:0043170,GO:0044238,GO:0044464,GO:0046677,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901565,GO:1901575 3.4.21.102 ko:K03797 - - - - ko00000,ko01000,ko01002 - - - BAGE,DUF3340,PDZ,Peptidase_S41 k59_1711281_1 1205753.A989_14982 7.07e-54 193.0 COG1703@1|root,COG1884@1|root,COG2185@1|root,COG1703@2|Bacteria,COG1884@2|Bacteria,COG2185@2|Bacteria,1MUXX@1224|Proteobacteria,1RSHX@1236|Gammaproteobacteria,1X3T3@135614|Xanthomonadales 135614|Xanthomonadales EI Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly icmF - 5.4.99.13 ko:K11942 - - - - ko00000,ko01000 - - - ArgK,B12-binding,MM_CoA_mutase k59_468300_1 314285.KT71_10924 1.12e-09 59.3 COG3791@1|root,COG3791@2|Bacteria,1N7AZ@1224|Proteobacteria,1SDYM@1236|Gammaproteobacteria,1JAX2@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Glutathione-dependent formaldehyde-activating - - - - - - - - - - - - GFA k59_468300_2 1001240.GY21_12180 9.68e-30 112.0 COG0346@1|root,COG0346@2|Bacteria,2IMSM@201174|Actinobacteria 201174|Actinobacteria E lactoylglutathione lyase activity - - - - - - - - - - - - Glyoxalase k59_1316229_1 1379281.AVAG01000014_gene1441 1.64e-44 161.0 COG3829@1|root,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria,42MFH@68525|delta/epsilon subdivisions,2WIRW@28221|Deltaproteobacteria,2M7VS@213115|Desulfovibrionales 28221|Deltaproteobacteria KT PFAM sigma-54 factor interaction domain-containing protein - - - - - - - - - - - - HTH_8,PAS_4,PAS_9,Sigma54_activat k59_864822_1 1229909.NSED_01895 3.73e-87 277.0 COG1404@1|root,arCOG00702@2157|Archaea,41SX3@651137|Thaumarchaeota 651137|Thaumarchaeota O Belongs to the peptidase S8 family - - - ko:K14647 ko02024,map02024 - - - ko00000,ko00001,ko01000,ko01002,ko03110 - - - PA,Peptidase_S8 k59_1598387_1 187272.Mlg_1944 3.7e-91 287.0 COG1185@1|root,COG1185@2|Bacteria,1MVB9@1224|Proteobacteria,1RNBF@1236|Gammaproteobacteria,1WW27@135613|Chromatiales 135613|Chromatiales J Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction pnp - 2.7.7.8 ko:K00962 ko00230,ko00240,ko03018,map00230,map00240,map03018 M00394 R00437,R00438,R00439,R00440 RC02795 ko00000,ko00001,ko00002,ko01000,ko03016,ko03019 - - - KH_1,PNPase,RNase_PH,RNase_PH_C,S1 k59_976036_2 247634.GPB2148_2520 2.84e-47 156.0 COG2050@1|root,COG2050@2|Bacteria,1PP3K@1224|Proteobacteria,1TAF9@1236|Gammaproteobacteria,1JB9N@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria Q Thioesterase superfamily - - - - - - - - - - - - 4HBT k59_422134_1 234267.Acid_5235 2.32e-53 184.0 COG0402@1|root,COG0402@2|Bacteria,3Y64N@57723|Acidobacteria 57723|Acidobacteria F Amidohydrolase family - - 3.5.4.28,3.5.4.31 ko:K12960 ko00270,ko01100,map00270,map01100 - R09660 RC00477 ko00000,ko00001,ko01000 - - - Amidohydro_1 k59_477711_2 33035.JPJF01000017_gene3751 0.00017 49.7 COG2211@1|root,COG2211@2|Bacteria,1TRYR@1239|Firmicutes,25C8G@186801|Clostridia,3XZ0S@572511|Blautia 186801|Clostridia G MFS/sugar transport protein - - - ko:K03292 - - - - ko00000 2.A.2 - - MFS_2 k59_1610670_1 13690.CP98_01814 4.16e-96 291.0 COG1024@1|root,COG1024@2|Bacteria,1R5V7@1224|Proteobacteria,2U7HV@28211|Alphaproteobacteria,2K448@204457|Sphingomonadales 204457|Sphingomonadales I Enoyl-CoA hydratase/isomerase - - - - - - - - - - - - ECH_1 k59_311627_1 1394178.AWOO02000045_gene6429 1.16e-29 122.0 COG0068@1|root,COG0068@2|Bacteria,2GJYF@201174|Actinobacteria,4EMM0@85012|Streptosporangiales 201174|Actinobacteria O HypF finger hypF - - ko:K04656 - - - - ko00000 - - - Acylphosphatase,Sua5_yciO_yrdC,zf-HYPF k59_985527_1 296587.XP_002508168.1 2.82e-70 235.0 COG4992@1|root,KOG1401@2759|Eukaryota,37NS6@33090|Viridiplantae,34GPP@3041|Chlorophyta 2759|Eukaryota E Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family - - - - - - - - - - - - Aminotran_3 k59_141269_1 436308.Nmar_1753 4.87e-19 85.9 arCOG08764@1|root,arCOG08764@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_141269_2 1229909.NSED_09330 2.62e-169 475.0 COG1010@1|root,arCOG00647@2157|Archaea,41S6W@651137|Thaumarchaeota 651137|Thaumarchaeota H Tetrapyrrole (Corrin/Porphyrin) Methylases - - 2.1.1.131 ko:K05934 ko00860,ko01100,map00860,map01100 - R05180,R05809 RC00003,RC01293,RC03471 ko00000,ko00001,ko01000 - - - TP_methylase k59_141269_3 436308.Nmar_1751 7.75e-51 170.0 COG0162@1|root,arCOG01886@2157|Archaea,41S8C@651137|Thaumarchaeota 651137|Thaumarchaeota J Tyrosine--tRNA ligase - - 6.1.1.1 ko:K01866 ko00970,map00970 M00359,M00360 R02918 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - tRNA-synt_1b k59_196159_1 378806.STAUR_3340 1.57e-144 442.0 COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,42M4I@68525|delta/epsilon subdivisions,2WJHM@28221|Deltaproteobacteria,2YUJ6@29|Myxococcales 28221|Deltaproteobacteria L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate uvrA - - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - ABC_tran k59_760015_1 1229909.NSED_09360 8.05e-93 273.0 arCOG08749@1|root,arCOG08749@2157|Archaea,41SRV@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1610691_2 1089547.KB913014_gene4817 3.37e-37 134.0 COG3328@1|root,COG3328@2|Bacteria,4NFQS@976|Bacteroidetes,47NSF@768503|Cytophagia 976|Bacteroidetes L Transposase, Mutator family - - - - - - - - - - - - Transposase_mut k59_1610693_1 566466.NOR53_1803 1.86e-15 80.5 2A448@1|root,30SP9@2|Bacteria,1NJJ4@1224|Proteobacteria,1SWRZ@1236|Gammaproteobacteria,1J9CQ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Peptidoglycan-binding protein, CsiV - - - - - - - - - - - - CsiV k59_253826_1 573065.Astex_1381 2.52e-123 365.0 COG1621@1|root,COG1621@2|Bacteria,1R103@1224|Proteobacteria 1224|Proteobacteria G BNR repeat-like domain - - - - - - - - - - - - BNR_2 k59_196171_1 930169.B5T_02716 4.92e-131 399.0 COG1251@1|root,COG1251@2|Bacteria,1MW58@1224|Proteobacteria,1RNGY@1236|Gammaproteobacteria,1XIC7@135619|Oceanospirillales 135619|Oceanospirillales C Belongs to the nitrite and sulfite reductase 4Fe-4S domain family nirB - 1.7.1.15 ko:K00362 ko00910,ko01120,map00910,map01120 M00530 R00787 RC00176 ko00000,ko00001,ko00002,ko01000 - - - Fer2_BFD,NIR_SIR,NIR_SIR_ferr,Pyr_redox_2 k59_760023_1 1239962.C943_00092 1.01e-37 135.0 COG2878@1|root,COG2878@2|Bacteria,4NFEB@976|Bacteroidetes 976|Bacteroidetes C electron transport complex, RnfABCDGE type, B subunit rnfB - - ko:K03616 - - - - ko00000 - - - FeS,Fer4 k59_816529_1 1415778.JQMM01000001_gene1605 1.2e-08 56.6 COG1960@1|root,COG1960@2|Bacteria,1MU20@1224|Proteobacteria,1RNV1@1236|Gammaproteobacteria,1J4EB@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria I COG1960 Acyl-CoA dehydrogenases - - - ko:K20035 ko00920,map00920 - R11130 RC03363 ko00000,ko00001,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_C,Acyl-CoA_dh_M,Acyl-CoA_dh_N,AcylCoA_DH_N k59_816529_2 118005.AWNK01000004_gene1075 6.74e-27 106.0 COG1047@1|root,COG1047@2|Bacteria 2|Bacteria O modulation by symbiont of host adenylate cyclase-mediated signal transduction slyD - 5.2.1.8 ko:K01802,ko:K03774,ko:K03775 - - - - ko00000,ko01000,ko03110 - - - FKBP_C,Nitro_FeMo-Co k59_816529_3 1122915.AUGY01000023_gene342 5.84e-18 84.3 COG1132@1|root,COG1132@2|Bacteria,1UZA0@1239|Firmicutes,4HC2E@91061|Bacilli,26VPZ@186822|Paenibacillaceae 91061|Bacilli V ABC transporter transmembrane region - - - - - - - - - - - - ABC_membrane,ABC_tran k59_706417_1 1380600.AUYN01000006_gene552 6.83e-208 592.0 COG4704@1|root,COG4704@2|Bacteria,4NGPF@976|Bacteroidetes,1HWU2@117743|Flavobacteriia 976|Bacteroidetes S Bacterial Ig-like domain - - - - - - - - - - - - Big_5 k59_533106_1 472759.Nhal_1250 1.65e-69 218.0 COG0483@1|root,COG0483@2|Bacteria,1NFR1@1224|Proteobacteria,1S31N@1236|Gammaproteobacteria,1WXP2@135613|Chromatiales 135613|Chromatiales G PFAM Inositol monophosphatase - - 3.1.3.25 ko:K01092 ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070 M00131 R01185,R01186,R01187 RC00078 ko00000,ko00001,ko00002,ko01000 - - - Inositol_P k59_1099711_1 283942.IL1615 1.11e-24 95.5 COG2963@1|root,COG2963@2|Bacteria,1N28U@1224|Proteobacteria,1S9BK@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Transposase - - - ko:K07483 - - - - ko00000 - - - HTH_Tnp_1 k59_593129_1 864073.HFRIS_012049 1.23e-65 207.0 COG0744@1|root,COG0744@2|Bacteria,1RDAQ@1224|Proteobacteria,2VHW8@28216|Betaproteobacteria,473WN@75682|Oxalobacteraceae 28216|Betaproteobacteria M Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors mtgA - 2.4.1.129 ko:K03814 ko00550,map00550 - - - ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 - Transgly k59_1554994_2 1174528.JH992887_gene6160 7.91e-46 162.0 COG4974@1|root,COG4974@2|Bacteria,1G66T@1117|Cyanobacteria 1117|Cyanobacteria L Belongs to the 'phage' integrase family - - - ko:K04763 - - - - ko00000,ko03036 - - - Phage_int_SAM_1,Phage_int_SAM_4,Phage_int_SAM_5,Phage_integrase k59_368553_1 706587.Desti_5134 3.2e-19 92.8 COG0515@1|root,COG0642@1|root,COG0784@1|root,COG2198@1|root,COG3899@1|root,COG0515@2|Bacteria,COG0784@2|Bacteria,COG2198@2|Bacteria,COG2205@2|Bacteria,COG3899@2|Bacteria,1NRP8@1224|Proteobacteria,42M0Y@68525|delta/epsilon subdivisions,2X7MY@28221|Deltaproteobacteria 28221|Deltaproteobacteria T Histidine kinase A domain protein - - - - - - - - - - - - AAA_16,GAF,GAF_2,HAMP,HATPase_c,HisKA,Pkinase,Response_reg k59_1665397_1 316407.85675690 1.55e-98 288.0 COG2068@1|root,COG2068@2|Bacteria,1QE5N@1224|Proteobacteria,1S3GJ@1236|Gammaproteobacteria,3XN3C@561|Escherichia 1236|Gammaproteobacteria S Transfers a CMP moiety from CTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin cytosine dinucleotide (Mo-MCD) cofactor. Is specific for CTP ygfJ GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006139,GO:0006725,GO:0006732,GO:0006753,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0019538,GO:0019637,GO:0019720,GO:0034641,GO:0034654,GO:0043167,GO:0043169,GO:0043170,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0046872,GO:0051186,GO:0051188,GO:0051189,GO:0055086,GO:0061602,GO:0070567,GO:0071704,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902759,GO:1902760 2.7.7.76 ko:K07141 ko00790,map00790 - R11582 - ko00000,ko00001,ko01000 - - iAPECO1_1312.APECO1_3649,iB21_1397.B21_02672,iECABU_c1320.ECABU_c31580,iECBD_1354.ECBD_0860,iECB_1328.ECB_02710,iECD_1391.ECD_02710,iEcHS_1320.EcHS_A3037 NTP_transf_3 k59_253844_1 240292.Ava_3837 6.91e-63 207.0 COG1075@1|root,COG1075@2|Bacteria,1GBMW@1117|Cyanobacteria,1HS0K@1161|Nostocales 1117|Cyanobacteria S acetyltransferases and hydrolases with the alpha beta hydrolase fold - - - - - - - - - - - - - k59_1268756_1 436308.Nmar_1457 9.36e-87 266.0 arCOG01778@1|root,arCOG01778@2157|Archaea,41SXW@651137|Thaumarchaeota 651137|Thaumarchaeota Q O-methyltransferase - - - - - - - - - - - - Methyltransf_31 k59_593137_1 1123508.JH636439_gene1133 9.02e-32 129.0 COG0515@1|root,COG0515@2|Bacteria,2IY73@203682|Planctomycetes 203682|Planctomycetes KLT PFAM Protein kinase domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase,TPR_16 k59_422179_1 985054.JQEZ01000001_gene2202 4.87e-48 171.0 COG2905@1|root,COG2905@2|Bacteria,1MW8U@1224|Proteobacteria,2TRZC@28211|Alphaproteobacteria,4NBMM@97050|Ruegeria 28211|Alphaproteobacteria T Putative nucleotidyltransferase substrate binding domain - - - ko:K07182 - - - - ko00000 - - - CBS,DUF294,DUF294_C,cNMP_binding k59_86179_1 365046.Rta_13340 4.56e-34 140.0 COG0745@1|root,COG2202@1|root,COG5002@1|root,COG0745@2|Bacteria,COG2202@2|Bacteria,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria 1224|Proteobacteria T Histidine kinase - - - - - - - - - - - - HAMP,HATPase_c,HisKA,PAS_4,Response_reg,dCache_1 k59_1438067_1 436308.Nmar_0194 2.34e-46 159.0 COG1819@1|root,arCOG01393@2157|Archaea,41T16@651137|Thaumarchaeota 651137|Thaumarchaeota G Glycosyltransferase family 28 C-terminal domain - - - - - - - - - - - - Glyco_tran_28_C k59_1438067_2 1229909.NSED_00445 5.31e-31 120.0 COG0527@1|root,arCOG00861@2157|Archaea,41SFK@651137|Thaumarchaeota 651137|Thaumarchaeota E Amino acid kinase family - - 2.7.2.4 ko:K00928 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00017,M00018,M00033,M00525,M00526,M00527 R00480 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase k59_706444_1 13690.CP98_04504 1.2e-120 374.0 COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,2TRFN@28211|Alphaproteobacteria,2K06M@204457|Sphingomonadales 204457|Sphingomonadales C Xanthine dehydrogenase - - 1.2.5.3 ko:K03520 - - R11168 RC02800 ko00000,ko01000 - - - Ald_Xan_dh_C,Ald_Xan_dh_C2 k59_929799_1 1163409.UUA_02181 1.28e-13 68.6 COG5606@1|root,COG5606@2|Bacteria,1NA3S@1224|Proteobacteria,1SAMC@1236|Gammaproteobacteria,1X8MN@135614|Xanthomonadales 135614|Xanthomonadales K Helix-turn-helix domain - - - - - - - - - - - - HTH_37 k59_1214765_1 1229909.NSED_07230 8.22e-71 218.0 arCOG08805@1|root,arCOG08805@2157|Archaea,41T3X@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1325592_1 1380600.AUYN01000006_gene304 5.41e-132 395.0 COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,4NETS@976|Bacteroidetes,1HY3A@117743|Flavobacteriia 976|Bacteroidetes EU peptidase dpp - 3.4.14.5 ko:K01278 ko04974,map04974 - - - ko00000,ko00001,ko01000,ko01002,ko04090,ko04147 - - - DPPIV_N,Peptidase_S9 k59_1498389_1 316407.1742546 1.71e-98 289.0 COG2110@1|root,COG2110@2|Bacteria,1MYT5@1224|Proteobacteria,1S7KD@1236|Gammaproteobacteria,3XPJT@561|Escherichia 1236|Gammaproteobacteria S Tail fiber assembly protein homolog from lambdoid prophage tfaQ - - - - - - - - - - - Caudo_TAP k59_196218_1 504487.JCM19302_3678 5.66e-77 230.0 COG0103@1|root,COG0103@2|Bacteria,4NNN1@976|Bacteroidetes,1I21V@117743|Flavobacteriia 976|Bacteroidetes J Belongs to the universal ribosomal protein uS9 family rpsI GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02996 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S9 k59_196218_2 313603.FB2170_03185 1.23e-14 72.0 COG0052@1|root,COG0052@2|Bacteria,4NER0@976|Bacteroidetes,1HWUX@117743|Flavobacteriia,2PG18@252356|Maribacter 976|Bacteroidetes J Ribosomal protein S2 rpsB GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02967 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S2 k59_1325593_1 1242864.D187_006570 5.53e-17 79.7 2E2XW@1|root,32XYS@2|Bacteria,1N3ID@1224|Proteobacteria,42UFM@68525|delta/epsilon subdivisions,2WQKF@28221|Deltaproteobacteria 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_985580_1 1415778.JQMM01000001_gene1728 1.6e-60 194.0 COG0398@1|root,COG0398@2|Bacteria,1RBAE@1224|Proteobacteria,1S32X@1236|Gammaproteobacteria,1J70B@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Protein of unknown function, DUF547 VV0483 - - - - - - - - - - - DUF547 k59_196219_1 323848.Nmul_A1268 1.78e-104 304.0 COG0231@1|root,COG0231@2|Bacteria,1MW2J@1224|Proteobacteria,2VZ53@28216|Betaproteobacteria,374MG@32003|Nitrosomonadales 28216|Betaproteobacteria J Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase efp - - ko:K02356 - - - - ko00000,ko03012 - - - EFP,EFP_N,Elong-fact-P_C k59_816564_1 1454004.AW11_02008 2.76e-79 247.0 COG0845@1|root,COG0845@2|Bacteria,1MUFW@1224|Proteobacteria,2VKCK@28216|Betaproteobacteria,1KQVQ@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria M Biotin-lipoyl like - - - ko:K03585 ko01501,ko01503,map01501,map01503 M00646,M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000,ko03036 2.A.6.2,8.A.1.6 - - HlyD_D23 k59_1665423_1 1049564.TevJSym_bb00050 2.07e-37 140.0 COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,1NBSJ@1224|Proteobacteria,1S0WV@1236|Gammaproteobacteria,1J5KF@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Pyruvate ferredoxin oxidoreductase and related 2-oxoacid ferredoxin oxidoreductases korA - 1.2.7.11,1.2.7.3 ko:K00174 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - PFOR_II,POR,POR_N k59_1555041_1 414684.RC1_2509 2.26e-108 321.0 COG0179@1|root,COG0179@2|Bacteria,1MV0V@1224|Proteobacteria,2TQYU@28211|Alphaproteobacteria,2JQ2T@204441|Rhodospirillales 204441|Rhodospirillales Q Fumarylacetoacetate (FAA) hydrolase family - - 3.7.1.2 ko:K16171 ko00350,ko00643,ko01100,ko01120,map00350,map00643,map01100,map01120 M00044 R01364 RC00326,RC00446 ko00000,ko00001,ko00002,ko01000 - - - FAA_hydrolase k59_1384950_1 1283300.ATXB01000001_gene1948 1.56e-42 159.0 COG1391@1|root,COG1391@2|Bacteria,1MU4I@1224|Proteobacteria,1RP9N@1236|Gammaproteobacteria,1XE97@135618|Methylococcales 135618|Methylococcales OT Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell glnE GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006541,GO:0006542,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008882,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016740,GO:0016772,GO:0016779,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0070566,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.7.42,2.7.7.89 ko:K00982 - - - - ko00000,ko01000 - - - GlnD_UR_UTase,GlnE k59_29120_2 1085623.GNIT_1040 1.32e-34 127.0 COG1235@1|root,COG1235@2|Bacteria,1NW4Z@1224|Proteobacteria,1RPS3@1236|Gammaproteobacteria,4656V@72275|Alteromonadaceae 1236|Gammaproteobacteria S Beta-lactamase superfamily domain - - - - - - - - - - - - Lactamase_B_2 k59_141333_1 887062.HGR_09503 1.46e-61 203.0 COG0108@1|root,COG0807@1|root,COG0108@2|Bacteria,COG0807@2|Bacteria,1MU8P@1224|Proteobacteria,2VH6S@28216|Betaproteobacteria,4A9S0@80864|Comamonadaceae 28216|Betaproteobacteria H Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate ribB - 3.5.4.25,4.1.99.12 ko:K14652 ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110 M00125,M00840 R00425,R07281 RC00293,RC01792,RC01815,RC02504 ko00000,ko00001,ko00002,ko01000 - - - DHBP_synthase,GTP_cyclohydro2 k59_253891_1 1049564.TevJSym_at00760 7.86e-118 355.0 COG3808@1|root,COG3808@2|Bacteria,1MUQ3@1224|Proteobacteria,1RN4K@1236|Gammaproteobacteria,1J5F2@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Sodium pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for Na( ) movement across the membrane hppA - 3.6.1.1 ko:K15987 ko00190,map00190 - - - ko00000,ko00001,ko01000 3.A.10.1 - - H_PPase k59_368609_1 187303.BN69_2716 8.68e-41 157.0 COG1020@1|root,COG3319@1|root,COG1020@2|Bacteria,COG3319@2|Bacteria,1QK4F@1224|Proteobacteria,2TRUN@28211|Alphaproteobacteria,36Z5P@31993|Methylocystaceae 28211|Alphaproteobacteria Q Thioesterase domain dhbF - 6.3.2.14 ko:K02364 ko01053,ko01110,ko01130,map01053,map01110,map01130 - R07644 RC00162,RC03046 ko00000,ko00001,ko01000,ko01008 - - - AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase k59_1610778_1 414684.RC1_2185 2.8e-47 167.0 COG0168@1|root,COG0168@2|Bacteria,1MUIJ@1224|Proteobacteria,2TRPX@28211|Alphaproteobacteria,2JPKV@204441|Rhodospirillales 204441|Rhodospirillales P Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA - - - ko:K03498 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - - TrkH k59_816595_1 1197477.IA57_07835 6.54e-104 310.0 COG2871@1|root,COG2871@2|Bacteria,4NFKC@976|Bacteroidetes,1HWV9@117743|Flavobacteriia 976|Bacteroidetes C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway nqrF - 1.6.5.8 ko:K00351 - - - - ko00000,ko01000 - - - FAD_binding_6,Fer2,NAD_binding_1 k59_86247_1 1121912.AUHD01000002_gene3220 2.11e-20 86.3 2CEYI@1|root,33P74@2|Bacteria,4NZG6@976|Bacteroidetes,1I6WG@117743|Flavobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_312875_2 396595.TK90_0291 1.88e-32 114.0 COG0234@1|root,COG0234@2|Bacteria,1MZ2X@1224|Proteobacteria,1S8YR@1236|Gammaproteobacteria,1WYJ2@135613|Chromatiales 135613|Chromatiales O Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter groS - - ko:K04078 - - - - ko00000,ko03029,ko03110 - - - Cpn10 k59_930641_1 316407.85676521 1.31e-106 318.0 COG0477@1|root,COG0477@2|Bacteria,1MU46@1224|Proteobacteria,1RMF0@1236|Gammaproteobacteria,3XM70@561|Escherichia 1236|Gammaproteobacteria P transmembrane transporter activity yhjE GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - - - - - - - - - - MFS_1,Sugar_tr k59_1438938_1 1122137.AQXF01000001_gene3268 4.25e-28 108.0 COG2834@1|root,COG2834@2|Bacteria,1RA1S@1224|Proteobacteria,2U58W@28211|Alphaproteobacteria 28211|Alphaproteobacteria M Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) lolA - - - - - - - - - - - LolA k59_1438938_2 1122137.AQXF01000001_gene3267 1.2e-38 143.0 COG1674@1|root,COG1674@2|Bacteria,1MVPI@1224|Proteobacteria,2TR48@28211|Alphaproteobacteria 28211|Alphaproteobacteria D COG1674 DNA segregation ATPase FtsK SpoIIIE and related proteins ftsK - - ko:K03466 - - - - ko00000,ko03036 3.A.12 - - FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma k59_1100570_1 570967.JMLV01000002_gene1730 7.09e-12 68.2 2E521@1|root,32ZVA@2|Bacteria,1N9PP@1224|Proteobacteria,2UG1E@28211|Alphaproteobacteria 28211|Alphaproteobacteria S TIGRFAM MJ0042 family finger-like protein - - - - - - - - - - - - DUF3426,zinc_ribbon_4 k59_1100570_2 1122137.AQXF01000001_gene2865 1.61e-20 86.7 COG2884@1|root,COG2884@2|Bacteria,1MVQ4@1224|Proteobacteria,2TS9Y@28211|Alphaproteobacteria 28211|Alphaproteobacteria D cell division ATP-binding protein FtsE ftsE - - ko:K09812 ko02010,map02010 M00256 - - ko00000,ko00001,ko00002,ko02000,ko03036 3.A.1.140 - - ABC_tran k59_1611584_1 1117314.PCIT_16110 6.23e-21 96.7 COG3279@1|root,COG3279@2|Bacteria,1R90R@1224|Proteobacteria,1S3H3@1236|Gammaproteobacteria,2Q1PP@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria KT LytTr DNA-binding domain rpfD - - - - - - - - - - - LytTR k59_312885_1 436308.Nmar_1379 5.83e-117 342.0 COG0473@1|root,arCOG01163@2157|Archaea,41S5U@651137|Thaumarchaeota 651137|Thaumarchaeota C Isocitrate isopropylmalate dehydrogenase - - 1.1.1.42 ko:K00031 ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146 M00009,M00010,M00173,M00740 R00267,R00268,R01899 RC00001,RC00084,RC00114,RC00626,RC02801 br01601,ko00000,ko00001,ko00002,ko01000 - - - Iso_dh k59_369706_1 316407.85676399 4.48e-185 516.0 COG1561@1|root,COG1561@2|Bacteria,1MWRA@1224|Proteobacteria,1RMAB@1236|Gammaproteobacteria,3XPBQ@561|Escherichia 1236|Gammaproteobacteria S Domain of unknown function (DUF1732) yicC GO:0000175,GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004532,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008408,GO:0009022,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016072,GO:0016075,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016796,GO:0016896,GO:0019439,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0140098,GO:0140101,GO:1901360,GO:1901361,GO:1901575 - - - - - - - - - - DUF1732,YicC_N k59_369706_2 199310.c4467 4.17e-102 299.0 COG0689@1|root,COG0689@2|Bacteria,1MVFZ@1224|Proteobacteria,1RNTB@1236|Gammaproteobacteria,3XMIK@561|Escherichia 1236|Gammaproteobacteria J Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates rph GO:0003674,GO:0003824,GO:0004518,GO:0004540,GO:0006139,GO:0006396,GO:0006399,GO:0006401,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016075,GO:0016787,GO:0016788,GO:0019439,GO:0034470,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0140098,GO:1901360,GO:1901361,GO:1901575 2.7.7.56 ko:K00989 - - - - ko00000,ko01000,ko03016 - - - RNase_PH,RNase_PH_C k59_1269575_2 702113.PP1Y_AT27712 9.13e-40 131.0 COG0333@1|root,COG0333@2|Bacteria,1PU3Y@1224|Proteobacteria,2UF54@28211|Alphaproteobacteria,2K6RY@204457|Sphingomonadales 204457|Sphingomonadales J Belongs to the bacterial ribosomal protein bL32 family rpmF - - ko:K02911 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011,ko03029 - - - Ribosomal_L32p k59_1269575_3 158500.BV97_01386 8.63e-114 335.0 COG0416@1|root,COG0416@2|Bacteria,1MVM3@1224|Proteobacteria,2TR53@28211|Alphaproteobacteria,2K0QU@204457|Sphingomonadales 204457|Sphingomonadales I Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA plsX - 2.3.1.15 ko:K03621 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R00851,R09380 RC00004,RC00039,RC00041 ko00000,ko00001,ko00002,ko01000,ko01004 - - - FA_synthesis k59_1047456_1 525897.Dbac_2629 9.49e-14 76.6 COG3322@1|root,COG5001@1|root,COG3322@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,42M0W@68525|delta/epsilon subdivisions,2WIK8@28221|Deltaproteobacteria,2M8CQ@213115|Desulfovibrionales 28221|Deltaproteobacteria T Diguanylate cyclase phosphodiesterase with PAS PAC sensor(S) - - - - - - - - - - - - CHASE4,EAL,GGDEF,PAS,PAS_4,PAS_8,PAS_9,dCache_1 k59_197336_1 1050202.KB913024_gene1670 6.47e-52 183.0 COG0786@1|root,COG0786@2|Bacteria,2I9AV@201174|Actinobacteria,409NR@622450|Actinopolysporales 201174|Actinobacteria E Sodium/glutamate symporter - - - ko:K03312 - - - - ko00000,ko02000 2.A.27 - - Glt_symporter k59_817696_1 1131266.ARWQ01000029_gene979 9.81e-61 194.0 arCOG08794@1|root,arCOG08794@2157|Archaea,41SR7@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_930654_1 76114.ebA6918 8.7e-66 234.0 COG1640@1|root,COG3280@1|root,COG1640@2|Bacteria,COG3280@2|Bacteria,1QTVJ@1224|Proteobacteria,2WGPV@28216|Betaproteobacteria,2KX9C@206389|Rhodocyclales 206389|Rhodocyclales G 4-alpha-glucanotransferase treY - 2.4.1.25,5.4.99.15 ko:K00705,ko:K06044 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R01824,R05196,R09995 RC00049 ko00000,ko00001,ko00002,ko01000 - GH13,GH77 - Alpha-amylase,Glyco_hydro_77 k59_1666259_1 443598.AUFA01000039_gene5980 3.2e-52 176.0 COG0697@1|root,COG0697@2|Bacteria,1MYHQ@1224|Proteobacteria,2U4JI@28211|Alphaproteobacteria,3K0JH@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria EG EamA-like transporter family - - - - - - - - - - - - EamA k59_1215933_1 1122137.AQXF01000004_gene1400 2.09e-267 741.0 COG0539@1|root,COG0539@2|Bacteria,1MVAV@1224|Proteobacteria,2TQPV@28211|Alphaproteobacteria 28211|Alphaproteobacteria J thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence rpsA - - ko:K02945 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - S1 k59_1269591_1 1487953.JMKF01000058_gene5079 6.93e-65 205.0 COG2135@1|root,COG2135@2|Bacteria,1G1SA@1117|Cyanobacteria,1HAGW@1150|Oscillatoriales 1117|Cyanobacteria S Belongs to the SOS response-associated peptidase family - - - - - - - - - - - - SRAP k59_878038_1 1122137.AQXF01000002_gene255 6.86e-85 260.0 COG0208@1|root,COG0208@2|Bacteria,1R4T3@1224|Proteobacteria,2U55H@28211|Alphaproteobacteria 28211|Alphaproteobacteria F P-aminobenzoate N-oxygenase AurF - - - - - - - - - - - - AurF k59_1047474_1 1328313.DS2_04030 4.52e-34 136.0 COG4775@1|root,COG4775@2|Bacteria,1MU0D@1224|Proteobacteria,1RMAP@1236|Gammaproteobacteria,464XP@72275|Alteromonadaceae 1236|Gammaproteobacteria M Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane bamA GO:0005575,GO:0005623,GO:0008104,GO:0008150,GO:0009279,GO:0009987,GO:0016020,GO:0016043,GO:0019867,GO:0022607,GO:0030312,GO:0030313,GO:0031224,GO:0031230,GO:0031241,GO:0031246,GO:0031975,GO:0032991,GO:0033036,GO:0034613,GO:0043163,GO:0043165,GO:0044085,GO:0044091,GO:0044425,GO:0044462,GO:0044464,GO:0045184,GO:0045229,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0061024,GO:0070727,GO:0071709,GO:0071840,GO:0071944,GO:0072657,GO:0090150,GO:0098552,GO:0098796,GO:1990063 - ko:K07277 - - - - ko00000,ko02000,ko03029 1.B.33 - - Bac_surface_Ag,POTRA k59_312921_1 938288.HG326226_gene940 7.46e-27 109.0 COG0668@1|root,COG0668@2|Bacteria,1TR9Z@1239|Firmicutes,24CAG@186801|Clostridia 186801|Clostridia M mechanosensitive ion channel mscS GO:0003674,GO:0005488,GO:0005515,GO:0042802 - ko:K22044 - - - - ko00000,ko02000 1.A.23.3 - - MS_channel k59_817716_1 1454004.AW11_00241 1.17e-29 116.0 COG0667@1|root,COG0667@2|Bacteria,1MVEH@1224|Proteobacteria,2VH1Q@28216|Betaproteobacteria,1KQ98@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria C Aldo/keto reductase family yhdN_1 - - - - - - - - - - - Aldo_ket_red k59_888241_1 351016.RAZWK3B_06362 1.95e-25 96.7 COG3369@1|root,COG3369@2|Bacteria,1N6QZ@1224|Proteobacteria,2UGR1@28211|Alphaproteobacteria,2P3HS@2433|Roseobacter 28211|Alphaproteobacteria S Iron-binding zinc finger CDGSH type - - - - - - - - - - - - zf-CDGSH k59_888241_2 291985.CCSI01000002_gene1296 1.94e-19 86.7 COG4221@1|root,COG4221@2|Bacteria,1MUF8@1224|Proteobacteria,2TR5S@28211|Alphaproteobacteria,2K1R4@204457|Sphingomonadales 204457|Sphingomonadales S Belongs to the short-chain dehydrogenases reductases (SDR) family - - 1.1.1.276 ko:K05886 - - - - ko00000,ko01000 - - - adh_short k59_994641_1 316407.85675613 2.34e-23 95.1 COG0780@1|root,COG2904@1|root,COG0780@2|Bacteria,COG2904@2|Bacteria,1MW0M@1224|Proteobacteria,1RNXM@1236|Gammaproteobacteria,3XM7E@561|Escherichia 1236|Gammaproteobacteria F Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) queF GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0016491,GO:0016645,GO:0016646,GO:0016651,GO:0016657,GO:0018130,GO:0019438,GO:0033739,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046116,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 1.7.1.13 ko:K06879,ko:K09457 ko00790,ko01100,map00790,map01100 - R07605 RC01875 ko00000,ko00001,ko01000,ko03016 - - iSFV_1184.SFV_2663,iSF_1195.SF2807,iS_1188.S3002 QueF,QueF_N k59_994641_2 316407.85675612 1.18e-98 287.0 28Q4G@1|root,2ZCMR@2|Bacteria,1RAB3@1224|Proteobacteria,1S2N3@1236|Gammaproteobacteria,3XMHR@561|Escherichia 1236|Gammaproteobacteria S Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function syd GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0008150,GO:0009898,GO:0016020,GO:0019897,GO:0019898,GO:0031234,GO:0043254,GO:0044087,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050794,GO:0051128,GO:0065007,GO:0071944,GO:0098552,GO:0098562 - ko:K15723 - - - - ko00000 - - - Syd k59_1277562_1 264730.PSPPH_1708 1.14e-97 312.0 COG4166@1|root,COG4166@2|Bacteria,1MUVU@1224|Proteobacteria,1S1X3@1236|Gammaproteobacteria,1Z5HA@136849|Pseudomonas syringae group 1236|Gammaproteobacteria E Bacterial extracellular solute-binding proteins, family 5 Middle - - - ko:K13893 ko02010,map02010 M00349 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5.21,3.A.1.5.24 - - SBP_bac_5 k59_1674149_1 686340.Metal_1024 8.73e-06 47.4 COG1138@1|root,COG1138@2|Bacteria,1MUQS@1224|Proteobacteria,1RMY5@1236|Gammaproteobacteria,1XEQK@135618|Methylococcales 135618|Methylococcales O Cytochrome c-type biogenesis protein CcmF ccmF - - ko:K02198 - - - - ko00000,ko02000 9.B.14.1 - - CcmF_C,Cytochrom_C_asm k59_1674149_2 312153.Pnuc_1514 3.15e-32 116.0 COG2332@1|root,COG2332@2|Bacteria,1RHN5@1224|Proteobacteria,2VRKZ@28216|Betaproteobacteria,1K8MK@119060|Burkholderiaceae 28216|Betaproteobacteria O Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH ccmE - - ko:K02197 - - - - ko00000 - - - CcmE k59_1784248_1 1122137.AQXF01000001_gene3033 1.98e-101 302.0 COG0204@1|root,COG0204@2|Bacteria,1N2DG@1224|Proteobacteria,2TT8Q@28211|Alphaproteobacteria 28211|Alphaproteobacteria I Acyl-transferase - - 2.3.1.51 ko:K00655 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R02241,R09381 RC00004,RC00037,RC00039 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Acyltransferase k59_265024_1 1504981.KO116_4831 3.41e-147 424.0 COG3328@1|root,COG3328@2|Bacteria,1QE3G@1224|Proteobacteria,1TBD7@1236|Gammaproteobacteria,1XQDQ@135619|Oceanospirillales 135619|Oceanospirillales L transposase activity - - - - - - - - - - - - - k59_718060_1 1157635.KB892046_gene5747 0.000138 47.4 COG0454@1|root,COG0456@2|Bacteria,2IFC0@201174|Actinobacteria 201174|Actinobacteria K Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_1,Acetyltransf_10 k59_718060_2 485918.Cpin_3448 4.09e-76 243.0 COG0167@1|root,COG1146@1|root,COG0167@2|Bacteria,COG1146@2|Bacteria,4NGSB@976|Bacteroidetes,1IUH6@117747|Sphingobacteriia 976|Bacteroidetes C dihydroorotate dehydrogenase - - 1.3.1.1,1.3.98.1 ko:K00226,ko:K17723 ko00240,ko00410,ko00770,ko01100,map00240,map00410,map00770,map01100 M00046,M00051 R00977,R01414,R01867,R11026 RC00051,RC00072,RC00123 ko00000,ko00001,ko00002,ko01000 - - - DHO_dh,Fer4_21 k59_827958_2 1121396.KB893082_gene954 3.98e-06 49.7 COG1190@1|root,COG1190@2|Bacteria,1MX1V@1224|Proteobacteria,42M90@68525|delta/epsilon subdivisions,2WJ9G@28221|Deltaproteobacteria,2MHV2@213118|Desulfobacterales 28221|Deltaproteobacteria J Belongs to the class-II aminoacyl-tRNA synthetase family lysS - 6.1.1.6 ko:K04567 ko00970,map00970 M00359,M00360 R03658 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_2,tRNA_anti-codon k59_1108916_1 1121937.AUHJ01000009_gene1553 5.78e-92 285.0 COG2010@1|root,COG2010@2|Bacteria,1N3PN@1224|Proteobacteria,1RNS0@1236|Gammaproteobacteria,46ADA@72275|Alteromonadaceae 1236|Gammaproteobacteria C Cytochrome D1 heme domain nirS - 1.7.2.1,1.7.99.1 ko:K15864 ko00910,ko01120,map00910,map01120 M00529 R00143,R00783,R00785 RC00086,RC02797 ko00000,ko00001,ko00002,ko01000 - - - Cytochrom_D1,Cytochrome_CBB3 k59_207777_1 1049564.TevJSym_af00900 1.2e-43 155.0 COG3437@1|root,COG3437@2|Bacteria,1P1A3@1224|Proteobacteria,1S2RH@1236|Gammaproteobacteria,1JBJA@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria KT HD domain - - - - - - - - - - - - HD_5,Response_reg k59_656768_1 1266908.AQPB01000052_gene770 2.94e-30 119.0 COG0614@1|root,COG0614@2|Bacteria,1MWVF@1224|Proteobacteria,1RMV8@1236|Gammaproteobacteria,1WZG8@135613|Chromatiales 135613|Chromatiales P PFAM periplasmic binding protein - - - ko:K02016 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko02000 3.A.1.14 - - Peripla_BP_2 k59_939291_1 1121921.KB898711_gene1891 2.41e-112 330.0 COG0825@1|root,COG0825@2|Bacteria,1MURN@1224|Proteobacteria,1RNN8@1236|Gammaproteobacteria,2PMHF@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria I Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit accA GO:0001676,GO:0003674,GO:0003824,GO:0003989,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009317,GO:0009329,GO:0009987,GO:0016053,GO:0016421,GO:0016874,GO:0016885,GO:0019752,GO:0032787,GO:0032991,GO:0042759,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0072330,GO:1901576,GO:1902494,GO:1990234 2.1.3.15,6.4.1.2 ko:K01962 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04386 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 - - iAF1260.b0185,iBWG_1329.BWG_0177,iEC55989_1330.EC55989_0179,iECDH10B_1368.ECDH10B_0165,iECDH1ME8569_1439.ECDH1ME8569_0178,iECED1_1282.ECED1_0191,iECH74115_1262.ECH74115_0195,iECIAI1_1343.ECIAI1_0185,iECNA114_1301.ECNA114_0175,iECO111_1330.ECO111_0186,iECO26_1355.ECO26_0187,iECP_1309.ECP_0193,iECSE_1348.ECSE_0184,iECSF_1327.ECSF_0200,iECSP_1301.ECSP_0184,iECW_1372.ECW_m0181,iECs_1301.ECs0187,iEKO11_1354.EKO11_3733,iEcDH1_1363.EcDH1_3418,iEcE24377_1341.EcE24377A_0189,iEcHS_1320.EcHS_A0187,iG2583_1286.G2583_0188,iJN746.PP_1607,iJO1366.b0185,iJR904.b0185,iLF82_1304.LF82_0008,iNRG857_1313.NRG857_00945,iSDY_1059.SDY_0201,iSFV_1184.SFV_0168,iSF_1195.SF0175,iSFxv_1172.SFxv_0185,iS_1188.S0178,iUMNK88_1353.UMNK88_190,iWFL_1372.ECW_m0181,iY75_1357.Y75_RS00935,iZ_1308.Z0197 ACCA k59_1056448_1 1144305.PMI02_04933 5.76e-55 180.0 2F6IW@1|root,33Z1T@2|Bacteria,1NKX4@1224|Proteobacteria 1224|Proteobacteria S sterol desaturase - - - - - - - - - - - - FA_hydroxylase k59_994664_1 633149.Bresu_1681 2.38e-34 130.0 COG1609@1|root,COG1609@2|Bacteria,1MW7E@1224|Proteobacteria,2TVGC@28211|Alphaproteobacteria,2KHSG@204458|Caulobacterales 204458|Caulobacterales K periplasmic binding protein LacI transcriptional regulator - - - - - - - - - - - - LacI,Peripla_BP_3 k59_40212_1 765912.Thimo_3053 3.52e-64 201.0 COG1898@1|root,COG1898@2|Bacteria,1R9YD@1224|Proteobacteria,1S245@1236|Gammaproteobacteria,1WVXE@135613|Chromatiales 135613|Chromatiales M Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose - - 5.1.3.13 ko:K01790 ko00521,ko00523,ko01130,map00521,map00523,map01130 M00793 R06514 RC01531 ko00000,ko00001,ko00002,ko01000 - - - dTDP_sugar_isom k59_1334371_1 1121921.KB898707_gene1125 5.95e-46 159.0 COG0667@1|root,COG0667@2|Bacteria,1MWGQ@1224|Proteobacteria,1RQ4H@1236|Gammaproteobacteria,2PNUK@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria C Aldo/keto reductase family pld1 - 1.1.1.122 ko:K00064 ko00051,ko00053,ko01100,ko01110,ko01120,map00051,map00053,map01100,map01110,map01120 M00114 R07675,R08926 RC00066,RC00161 ko00000,ko00001,ko00002,ko01000 - - - Aldo_ket_red k59_1108952_1 488538.SAR116_1030 8.6e-104 310.0 COG1186@1|root,COG1186@2|Bacteria,1MUAW@1224|Proteobacteria,2TR9V@28211|Alphaproteobacteria,4BP5Y@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria J Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA prfB - - ko:K02836 - - - - ko00000,ko03012 - - - PCRF,RF-1 k59_1784305_1 1122604.JONR01000006_gene2736 2.94e-21 100.0 COG0591@1|root,COG0642@1|root,COG0591@2|Bacteria,COG2205@2|Bacteria,1MUY7@1224|Proteobacteria,1RP2U@1236|Gammaproteobacteria,1X43U@135614|Xanthomonadales 135614|Xanthomonadales T Histidine kinase - - - - - - - - - - - - HATPase_c,HisKA,PAS_7,Response_reg k59_1277605_1 130081.XP_005709379.1 1.17e-144 430.0 COG0318@1|root,KOG1176@2759|Eukaryota 2759|Eukaryota IQ ligase activity - - 6.2.1.8 ko:K18661,ko:K22133 ko00280,ko00630,ko01100,map00280,map00630,map01100 - R01558,R03383 RC00004,RC00137,RC00179 ko00000,ko00001,ko01000 - - - AMP-binding,AMP-binding_C,FSH1,PP-binding k59_605032_1 436308.Nmar_0207 2.14e-100 304.0 COG2368@1|root,arCOG02143@2157|Archaea,41SA0@651137|Thaumarchaeota 651137|Thaumarchaeota Q Vinylacetyl-CoA Delta-isomerase - - 4.2.1.120,5.3.3.3 ko:K14534 ko00650,ko00720,ko01100,ko01120,ko01200,map00650,map00720,map01100,map01120,map01200 M00374,M00375 R03031,R10782 RC01857,RC03277 ko00000,ko00001,ko00002,ko01000 - - - HpaB,HpaB_N k59_40234_1 765910.MARPU_15935 7.97e-100 308.0 COG0661@1|root,COG0661@2|Bacteria,1MU1Z@1224|Proteobacteria,1RNQM@1236|Gammaproteobacteria,1WWEC@135613|Chromatiales 135613|Chromatiales S Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis ubiB - - ko:K03688 - - - - ko00000 - - - ABC1 k59_828001_2 796606.BMMGA3_07020 1.93e-30 116.0 COG3510@1|root,COG3510@2|Bacteria,1V88X@1239|Firmicutes,4HK2A@91061|Bacilli,1ZMUG@1386|Bacillus 91061|Bacilli V Cephalosporin hydroxylase - - - - - - - - - - - - CmcI k59_1509520_1 1416759.AYMR01000017_gene2381 3.96e-08 56.6 COG0621@1|root,COG0621@2|Bacteria,2GJEV@201174|Actinobacteria,4FK4K@85023|Microbacteriaceae 201174|Actinobacteria J Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine miaB - 2.8.4.3 ko:K06168 - - R10645,R10646,R10647 RC00003,RC00980,RC03221,RC03222 ko00000,ko01000,ko03016 - - - Radical_SAM,TRAM,UPF0004 k59_1509520_2 593907.Celgi_2030 3.44e-24 100.0 COG0324@1|root,COG0324@2|Bacteria,2GKFT@201174|Actinobacteria,4F0Y4@85016|Cellulomonadaceae 201174|Actinobacteria J Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) miaA GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016765,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0052381,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.5.1.75 ko:K00791 ko00908,ko01100,ko01110,map00908,map01100,map01110 - R01122 RC02820 ko00000,ko00001,ko01000,ko01006,ko03016 - - - IPPT k59_656802_1 1260251.SPISAL_01535 1.75e-125 366.0 COG0320@1|root,COG0320@2|Bacteria,1MVRD@1224|Proteobacteria,1RMAT@1236|Gammaproteobacteria,1WXEN@135613|Chromatiales 135613|Chromatiales H Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives lipA - 2.8.1.8 ko:K03644 ko00785,ko01100,map00785,map01100 - R07767,R07768 RC01978 ko00000,ko00001,ko01000 - - - LIAS_N,Radical_SAM k59_718123_1 1144305.PMI02_04063 7.7e-127 365.0 COG0854@1|root,COG0854@2|Bacteria,1MU9W@1224|Proteobacteria,2TTTF@28211|Alphaproteobacteria,2K0T4@204457|Sphingomonadales 204457|Sphingomonadales H Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate pdxJ - 2.6.99.2 ko:K03474 ko00750,ko01100,map00750,map01100 M00124 R05838 RC01476 ko00000,ko00001,ko00002,ko01000 - - - PdxJ k59_718123_3 555793.WSK_2479 5.55e-77 231.0 COG0736@1|root,COG0736@2|Bacteria,1MZBF@1224|Proteobacteria,2U77S@28211|Alphaproteobacteria,2K4ID@204457|Sphingomonadales 204457|Sphingomonadales I Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein acpS - 2.7.8.7 ko:K00997 ko00770,map00770 - R01625 RC00002 ko00000,ko00001,ko01000 - - - ACPS k59_718124_1 1396858.Q666_07680 2.09e-60 211.0 COG1109@1|root,COG1109@2|Bacteria,1MUA5@1224|Proteobacteria,1RMU8@1236|Gammaproteobacteria,46404@72275|Alteromonadaceae 1236|Gammaproteobacteria G Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II algC GO:0003674,GO:0003824,GO:0004615,GO:0005975,GO:0008150,GO:0008152,GO:0016853,GO:0016866,GO:0016868,GO:0044238,GO:0071704 5.4.2.2,5.4.2.8 ko:K15778 ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130 M00114 R00959,R01057,R01818,R08639 RC00408 ko00000,ko00001,ko00002,ko01000 - - - PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV k59_1396409_1 1120953.AUBH01000002_gene1457 3.16e-68 213.0 COG4660@1|root,COG4660@2|Bacteria,1MW6N@1224|Proteobacteria,1RMEH@1236|Gammaproteobacteria,464BB@72275|Alteromonadaceae 1236|Gammaproteobacteria C Part of a membrane complex involved in electron transport rnfE - - ko:K03613 - - - - ko00000 - - - Rnf-Nqr k59_1396409_2 1283300.ATXB01000001_gene1167 1.65e-70 218.0 COG4657@1|root,COG4657@2|Bacteria,1MU8X@1224|Proteobacteria,1RQDN@1236|Gammaproteobacteria,1XGZB@135618|Methylococcales 135618|Methylococcales C Rnf-Nqr subunit, membrane protein - - - ko:K03617 - - - - ko00000 - - - Rnf-Nqr k59_1334407_1 76114.ebA1017 1.14e-54 192.0 COG0243@1|root,COG0243@2|Bacteria,1P01N@1224|Proteobacteria,2VKSY@28216|Betaproteobacteria,2KVC6@206389|Rhodocyclales 28216|Betaproteobacteria C Molybdopterin oxidoreductase Fe4S4 domain - - - - - - - - - - - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding k59_769193_1 316407.1799606 2.26e-65 207.0 COG0463@1|root,COG0463@2|Bacteria,1MWE5@1224|Proteobacteria,1RPCE@1236|Gammaproteobacteria,3XPBE@561|Escherichia 1236|Gammaproteobacteria I Catalyzes the transfer of 4-deoxy-4-formamido-L- arabinose from UDP to undecaprenyl phosphate. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides arnC GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0016740,GO:0016757,GO:0016763,GO:0044464,GO:0071944,GO:0099621 2.4.2.53 ko:K10012 ko00520,ko01503,map00520,map01503 M00721,M00761 R07661 RC00005,RC02954 ko00000,ko00001,ko00002,ko01000,ko01005,ko02000 4.D.2.1.8 GT2 iAPECO1_1312.APECO1_4307,iE2348C_1286.E2348C_2398,iECABU_c1320.ECABU_c25880,iECED1_1282.ECED1_2720,iECOK1_1307.ECOK1_2490,iECP_1309.ECP_2297,iECS88_1305.ECS88_2403,iLF82_1304.LF82_0138,iNRG857_1313.NRG857_11430,iUMN146_1321.UM146_05530,iUTI89_1310.UTI89_C2536,ic_1306.c2796 Glycos_transf_2 k59_769193_2 316407.1799607 6.52e-42 150.0 COG0223@1|root,COG0451@1|root,COG0223@2|Bacteria,COG0451@2|Bacteria,1MXKV@1224|Proteobacteria,1RNJD@1236|Gammaproteobacteria,3XPGM@561|Escherichia 1236|Gammaproteobacteria I Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto- arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4- amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido- arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides arnA GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006040,GO:0006139,GO:0006725,GO:0006793,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009225,GO:0009226,GO:0009987,GO:0016043,GO:0016491,GO:0016614,GO:0016616,GO:0016740,GO:0016741,GO:0016742,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0022607,GO:0033319,GO:0033320,GO:0034214,GO:0034641,GO:0034654,GO:0036094,GO:0042221,GO:0042802,GO:0043167,GO:0043168,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046349,GO:0046483,GO:0046677,GO:0048037,GO:0048040,GO:0050662,GO:0050896,GO:0051259,GO:0051287,GO:0055086,GO:0055114,GO:0065003,GO:0070403,GO:0071704,GO:0071840,GO:0097159,GO:0099618,GO:0099619,GO:1901135,GO:1901137,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:2001313,GO:2001315 1.1.1.305,2.1.2.13,5.1.3.2 ko:K01784,ko:K10011 ko00052,ko00520,ko01100,ko01503,map00052,map00520,map01100,map01503 M00361,M00362,M00632,M00721,M00761 R00291,R02984,R07658,R07660 RC00026,RC00289,RC01575,RC01812 ko00000,ko00001,ko00002,ko01000,ko01005 - - iPC815.YPO2420,iSFV_1184.SFV_2325 Epimerase,Formyl_trans_C,Formyl_trans_N k59_40251_1 1297742.A176_00178 2.11e-51 177.0 COG1109@1|root,COG1109@2|Bacteria,1MU24@1224|Proteobacteria,42M6I@68525|delta/epsilon subdivisions,2WJTV@28221|Deltaproteobacteria,2YU3G@29|Myxococcales 28221|Deltaproteobacteria G Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate glmM - 5.4.2.10 ko:K03431 ko00520,ko01100,ko01130,map00520,map01100,map01130 - R02060 RC00408 ko00000,ko00001,ko01000 - - iAF987.Gmet_1886 PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV k59_40251_2 56110.Oscil6304_4869 3.91e-41 147.0 COG0854@1|root,COG0854@2|Bacteria,1G0QW@1117|Cyanobacteria,1H8WB@1150|Oscillatoriales 1117|Cyanobacteria H Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate pdxJ GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008614,GO:0008615,GO:0009058,GO:0009110,GO:0009987,GO:0016740,GO:0016769,GO:0017144,GO:0018130,GO:0019438,GO:0033856,GO:0034641,GO:0042364,GO:0042816,GO:0042819,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072524,GO:0072525,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 2.6.99.2 ko:K03474 ko00750,ko01100,map00750,map01100 M00124 R05838 RC01476 ko00000,ko00001,ko00002,ko01000 - - - PdxJ k59_40251_3 997346.HMPREF9374_2946 9.73e-19 89.0 COG0062@1|root,COG0063@1|root,COG0062@2|Bacteria,COG0063@2|Bacteria,1TNZE@1239|Firmicutes,4HBZC@91061|Bacilli,27CR2@186824|Thermoactinomycetaceae 91061|Bacilli G YjeF-related protein N-terminus nnrD - 4.2.1.136,5.1.99.6 ko:K17758,ko:K17759 - - - - ko00000,ko01000 - - - Carb_kinase,YjeF_N k59_150282_1 1121912.AUHD01000001_gene2401 7.29e-100 313.0 COG0550@1|root,COG0550@2|Bacteria,4NF9S@976|Bacteroidetes,1HX5E@117743|Flavobacteriia 976|Bacteroidetes L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone topA - 5.99.1.2 ko:K03168 - - - - ko00000,ko01000,ko03032,ko03400 - - - Topoisom_bac,Toprim,Toprim_C_rpt k59_656815_1 754477.Q7C_2363 1.45e-14 76.3 COG0342@1|root,COG0342@2|Bacteria,1MV5U@1224|Proteobacteria,1RMIQ@1236|Gammaproteobacteria,45ZN8@72273|Thiotrichales 72273|Thiotrichales U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA secD - - ko:K03072 ko03060,ko03070,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 2.A.6.4,3.A.5.2,3.A.5.7 - - SecD-TM1,SecD_SecF,Sec_GG k59_431943_1 930169.B5T_03817 7.22e-80 250.0 COG0162@1|root,COG0162@2|Bacteria,1MVUQ@1224|Proteobacteria,1RPKC@1236|Gammaproteobacteria,1XHJ0@135619|Oceanospirillales 135619|Oceanospirillales J Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) tyrS - 6.1.1.1 ko:K01866 ko00970,map00970 M00359,M00360 R02918 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - S4,tRNA-synt_1b k59_1448781_1 1198232.CYCME_1066 6.57e-41 150.0 COG1345@1|root,COG1345@2|Bacteria,1MUVP@1224|Proteobacteria,1RS2S@1236|Gammaproteobacteria,460Z0@72273|Thiotrichales 72273|Thiotrichales N Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end - - - ko:K02407 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - Flagellin_IN,FliD_C,FliD_N k59_1448781_2 1196835.A458_11520 8.17e-11 60.8 COG1516@1|root,COG1516@2|Bacteria,1MZ3G@1224|Proteobacteria,1S8TQ@1236|Gammaproteobacteria,1Z33V@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria N Flagellar protein FliS fliS - - ko:K02422 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - FliS k59_542784_1 504472.Slin_0380 6.88e-44 157.0 COG4805@1|root,COG4805@2|Bacteria,4NFAK@976|Bacteroidetes,47MIN@768503|Cytophagia 976|Bacteroidetes S Bacterial protein of unknown function (DUF885) - - - - - - - - - - - - DUF885 k59_605954_1 1116472.MGMO_92c00340 2.17e-73 256.0 COG0642@1|root,COG0642@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,1SKTW@1236|Gammaproteobacteria,1XEM2@135618|Methylococcales 1236|Gammaproteobacteria T Signal transduction histidine kinase, subgroup 1, dimerisation phosphoacceptor region - - - - - - - - - - - - CHASE8,GAF_2,HAMP,HATPase_c,HisKA,Hpt,PAS_3,PAS_4,PAS_7,PAS_9,Response_reg k59_208778_1 661367.LLO_1605 7.98e-94 315.0 COG2373@1|root,COG2373@2|Bacteria,1MV7J@1224|Proteobacteria,1RNRY@1236|Gammaproteobacteria,1JCHF@118969|Legionellales 118969|Legionellales S Alpha-2-macroglobulin family - - - ko:K06894 - - - - ko00000 - - - A2M,A2M_N,A2M_N_2,MG1 k59_770031_2 985867.AEWF01000004_gene350 1.58e-07 53.5 COG0654@1|root,COG0654@2|Bacteria,1MU6I@1224|Proteobacteria,2TRZU@28211|Alphaproteobacteria,47F81@766|Rickettsiales 766|Rickettsiales CH Ubiquinone biosynthesis hydroxylase, UbiH UbiF VisC COQ6 ubiH - - ko:K03185 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00117 R04989,R08773 RC02670 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_3 k59_657868_2 948106.AWZT01000005_gene4465 1.08e-32 123.0 COG2896@1|root,COG2896@2|Bacteria,1MW3W@1224|Proteobacteria,2VHW4@28216|Betaproteobacteria,1K3UV@119060|Burkholderiaceae 28216|Betaproteobacteria H Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate moaA - 4.1.99.22 ko:K03639 ko00790,ko01100,ko04122,map00790,map01100,map04122 - R09394 RC03420 ko00000,ko00001,ko01000 - - - Fer4_12,Fer4_14,Mob_synth_C,Radical_SAM k59_208782_1 1071679.BG57_08855 5.01e-89 276.0 COG2225@1|root,COG2225@2|Bacteria,1MVEV@1224|Proteobacteria,2VJK0@28216|Betaproteobacteria,1K4T4@119060|Burkholderiaceae 28216|Betaproteobacteria H Belongs to the malate synthase family aceB - 2.3.3.9 ko:K01638 ko00620,ko00630,ko01100,ko01110,ko01120,ko01200,map00620,map00630,map01100,map01110,map01120,map01200 M00012 R00472 RC00004,RC00308,RC02747 ko00000,ko00001,ko00002,ko01000 - - - Malate_synthase k59_770034_1 713586.KB900536_gene2239 1.48e-77 240.0 COG0408@1|root,COG0408@2|Bacteria,1MWMF@1224|Proteobacteria,1RMM8@1236|Gammaproteobacteria,1WX13@135613|Chromatiales 135613|Chromatiales H Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX hemF GO:0003674,GO:0005488,GO:0005515,GO:0042802,GO:0042803,GO:0046983 1.3.3.3 ko:K00228 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R03220 RC00884 ko00000,ko00001,ko00002,ko01000 - - - Coprogen_oxidas k59_96816_1 1122137.AQXF01000007_gene3567 5.74e-147 430.0 COG0033@1|root,COG0033@2|Bacteria,1MU5S@1224|Proteobacteria,2TRUJ@28211|Alphaproteobacteria 28211|Alphaproteobacteria G Phosphoglucomutase pgm - 5.4.2.2 ko:K01835 ko00010,ko00030,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130 M00549 R00959,R01057,R08639 RC00408 ko00000,ko00001,ko00002,ko01000 - - - PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV k59_96816_2 1177928.TH2_07041 5.63e-44 152.0 COG1595@1|root,COG1595@2|Bacteria,1RHRR@1224|Proteobacteria,2U9G0@28211|Alphaproteobacteria,2JS74@204441|Rhodospirillales 204441|Rhodospirillales K Belongs to the sigma-70 factor family. ECF subfamily - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4,Sigma70_r4_2 k59_96816_3 1121948.AUAC01000003_gene2387 6.07e-30 117.0 COG3806@1|root,COG3806@2|Bacteria,1RI6T@1224|Proteobacteria,2TVH9@28211|Alphaproteobacteria,43YFK@69657|Hyphomonadaceae 28211|Alphaproteobacteria T ChrR Cupin-like domain chrR - - ko:K07167 - - - - ko00000 - - - Cupin_7,zf-HC2 k59_1675308_2 1229909.NSED_01780 5.2e-39 139.0 COG1525@1|root,arCOG03192@2157|Archaea 2157|Archaea L COG1525 Micrococcal nuclease (thermonuclease) homologs - - 3.1.31.1 ko:K01174 - - - - ko00000,ko01000 - - - SNase k59_380707_1 1536773.R70331_16735 4.85e-35 127.0 COG3576@1|root,COG3576@2|Bacteria,1UZ02@1239|Firmicutes,4HEN8@91061|Bacilli,26R91@186822|Paenibacillaceae 91061|Bacilli S Pyridoxamine 5'-phosphate oxidase - - - ko:K07006 - - - - ko00000 - - - Putative_PNPOx k59_1567926_1 1509403.GW12_16490 3.47e-73 247.0 COG0567@1|root,COG0567@2|Bacteria,1MVBF@1224|Proteobacteria,1RN8K@1236|Gammaproteobacteria,3NIYG@468|Moraxellaceae 1236|Gammaproteobacteria C COG0567 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes sucA GO:0003674,GO:0003824,GO:0004591,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016491,GO:0016624,GO:0016903,GO:0016999,GO:0017144,GO:0019752,GO:0032991,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045239,GO:0045240,GO:0045252,GO:0045333,GO:0055114,GO:0071704,GO:0072350,GO:1902494,GO:1990204,GO:1990234 1.2.4.2 ko:K00164 ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00032 R00621,R01933,R01940,R03316,R08549 RC00004,RC00027,RC00627,RC02743,RC02833,RC02883 br01601,ko00000,ko00001,ko00002,ko01000 - - - 2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr k59_605989_1 1088721.NSU_3434 1.55e-87 269.0 COG2141@1|root,COG2141@2|Bacteria,1MX64@1224|Proteobacteria,2VEY3@28211|Alphaproteobacteria,2KAGJ@204457|Sphingomonadales 204457|Sphingomonadales C Luciferase-like monooxygenase - - - - - - - - - - - - Bac_luciferase k59_657890_1 1123242.JH636436_gene594 6.13e-72 223.0 COG1611@1|root,COG1611@2|Bacteria,2IZK9@203682|Planctomycetes 203682|Planctomycetes S Belongs to the LOG family - - 3.2.2.10 ko:K06966 ko00230,ko00240,map00230,map00240 - R00182,R00510 RC00063,RC00318 ko00000,ko00001,ko01000 - - - Lysine_decarbox k59_657890_2 290397.Adeh_3728 5.59e-21 101.0 COG3829@1|root,COG3852@1|root,COG3829@2|Bacteria,COG3852@2|Bacteria,1QW3X@1224|Proteobacteria 1224|Proteobacteria T PAS domain containing protein - - 3.1.3.3 ko:K07315 - - - - ko00000,ko01000,ko03021 - - - HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg,SpoIIE k59_1335409_2 1088721.NSU_1493 5.32e-90 280.0 COG4638@1|root,COG4638@2|Bacteria,1N3CA@1224|Proteobacteria,2VG2K@28211|Alphaproteobacteria,2K2PB@204457|Sphingomonadales 204457|Sphingomonadales P Rieske [2Fe-2S] domain - - - - - - - - - - - - Rieske k59_1448824_1 498211.CJA_1786 4.33e-61 206.0 COG0322@1|root,COG0322@2|Bacteria,1MV38@1224|Proteobacteria,1RNGV@1236|Gammaproteobacteria,1FH43@10|Cellvibrio 1236|Gammaproteobacteria L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision uvrC GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009314,GO:0009380,GO:0009381,GO:0009628,GO:0009987,GO:0016787,GO:0016788,GO:0032991,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1902494,GO:1905347,GO:1905348,GO:1990391 - ko:K03703 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - GIY-YIG,HHH,HHH_2,HHH_5,UVR,UvrC_HhH_N k59_542819_1 1175306.GWL_01570 4.83e-44 160.0 COG0642@1|root,COG0642@2|Bacteria,1QTSX@1224|Proteobacteria,2VI80@28216|Betaproteobacteria,473A1@75682|Oxalobacteraceae 28216|Betaproteobacteria T PFAM HAMP domain, Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, His Kinase A (phosphoacceptor) domain, Two-component sensor kinase N-terminal - - 2.7.13.3 ko:K07649 ko02020,map02020 M00457 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - 2CSK_N,HATPase_c,HisKA k59_1675329_1 637389.Acaty_c1276 1.29e-62 216.0 COG0247@1|root,COG0277@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,1MU43@1224|Proteobacteria,1RMRH@1236|Gammaproteobacteria,2NBY2@225057|Acidithiobacillales 225057|Acidithiobacillales C Domain of unknown function (DUF3400) - - - - - - - - - - - - CCG,DUF3400,DUF3683,FAD-oxidase_C,FAD_binding_4,Fer4_8 k59_266090_1 762903.Pedsa_2411 1.37e-19 93.6 COG2911@1|root,COG3209@1|root,COG3391@1|root,COG4386@1|root,COG4677@1|root,COG4932@1|root,COG5184@1|root,COG5492@1|root,COG2911@2|Bacteria,COG3209@2|Bacteria,COG3391@2|Bacteria,COG4386@2|Bacteria,COG4677@2|Bacteria,COG4932@2|Bacteria,COG5184@2|Bacteria,COG5492@2|Bacteria,4NHHA@976|Bacteroidetes,1IVM6@117747|Sphingobacteriia 976|Bacteroidetes M Domain of unknown function - - - ko:K20276 ko02024,map02024 - - - ko00000,ko00001 - - - Big_4,CHU_C,Calx-beta,He_PIG,NHL,TIG,fn3 k59_96846_1 314285.KT71_06779 2.25e-09 60.1 COG0719@1|root,COG0719@2|Bacteria,1MVK0@1224|Proteobacteria,1RP2A@1236|Gammaproteobacteria,1J4N2@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O COG0719 ABC-type transport system involved in Fe-S cluster assembly, permease component sufD GO:0006790,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0016226,GO:0022607,GO:0031163,GO:0044085,GO:0044237,GO:0050896,GO:0051186,GO:0071840 - ko:K09015 - - - - ko00000 - - iB21_1397.B21_01640,iECBD_1354.ECBD_1964,iECB_1328.ECB_01650,iECD_1391.ECD_01650,iUMNK88_1353.UMNK88_2144 UPF0051 k59_96846_2 203122.Sde_1415 5.53e-46 154.0 COG0396@1|root,COG0396@2|Bacteria,1MUGK@1224|Proteobacteria,1RPFE@1236|Gammaproteobacteria,4659A@72275|Alteromonadaceae 1236|Gammaproteobacteria O COG0396 ABC-type transport system involved in Fe-S cluster assembly, ATPase component sufC GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006790,GO:0008150,GO:0008152,GO:0009314,GO:0009628,GO:0009987,GO:0016043,GO:0016226,GO:0022607,GO:0031163,GO:0044085,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051186,GO:0071840 - ko:K09013 - - - - ko00000,ko02000 - - iECH74115_1262.ECH74115_2396,iECIAI1_1343.ECIAI1_1734,iECIAI39_1322.ECIAI39_1376,iECSP_1301.ECSP_2249,iECs_1301.ECs2389,iEcSMS35_1347.EcSMS35_1514,iG2583_1286.G2583_2077,iSFV_1184.SFV_1705,iSFxv_1172.SFxv_1919,iSSON_1240.SSON_1474,iS_1188.S1844,iZ_1308.Z2710 ABC_tran k59_828941_1 670292.JH26_08850 3.86e-16 80.1 COG0457@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2TRUI@28211|Alphaproteobacteria,1JTMR@119045|Methylobacteriaceae 28211|Alphaproteobacteria T Adenylate cyclase - - - - - - - - - - - - Guanylate_cyc k59_889301_1 1056820.KB900656_gene3620 3.8e-54 180.0 28JEH@1|root,2Z98N@2|Bacteria,1RIK2@1224|Proteobacteria,1S7I8@1236|Gammaproteobacteria,2PNXX@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_96853_1 1229203.KI301992_gene1079 4.47e-07 52.0 COG1187@1|root,COG1187@2|Bacteria,2GJ4N@201174|Actinobacteria,3UWKC@52018|unclassified Actinobacteria (class) 201174|Actinobacteria J RNA pseudouridylate synthase rluB GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360 5.4.99.19,5.4.99.22 ko:K06178,ko:K06183 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2,S4 k59_889302_1 1207055.C100_16815 8.4e-304 837.0 COG1233@1|root,COG1233@2|Bacteria,1MV2R@1224|Proteobacteria,2TSR0@28211|Alphaproteobacteria,2K3Q1@204457|Sphingomonadales 204457|Sphingomonadales Q Flavin containing amine oxidoreductase - - - - - - - - - - - - Amino_oxidase,NAD_binding_8 k59_889302_2 491952.Mar181_2394 3.09e-27 100.0 2FHPP@1|root,349H9@2|Bacteria,1NC8W@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_719189_1 316407.85676316 7.24e-126 374.0 COG1263@1|root,COG1264@1|root,COG2190@1|root,COG1263@2|Bacteria,COG1264@2|Bacteria,COG2190@2|Bacteria,1MXEG@1224|Proteobacteria,1RNEG@1236|Gammaproteobacteria,3XMAD@561|Escherichia 1236|Gammaproteobacteria G The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in beta-glucoside transport bglF GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0008643,GO:0009401,GO:0015144,GO:0016020,GO:0016740,GO:0016772,GO:0016773,GO:0022804,GO:0022857,GO:0034219,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0090563 - ko:K02755,ko:K02756,ko:K02757 ko02060,map02060 M00271 - - ko00000,ko00001,ko00002,ko01000,ko02000 4.A.1.2.11,4.A.1.2.2,4.A.1.2.5,4.A.1.2.6 - iE2348C_1286.E2348C_4032,iEcHS_1320.EcHS_A3936 PTS_EIIA_1,PTS_EIIB,PTS_EIIC k59_1335457_1 1280949.HAD_05160 1.89e-113 337.0 COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2TR7Q@28211|Alphaproteobacteria,43WK1@69657|Hyphomonadaceae 28211|Alphaproteobacteria C acyl-CoA transferases carnitine dehydratase - - 2.8.3.16 ko:K07749 - - - - ko00000,ko01000 - - - CoA_transf_3 k59_1683876_1 1366050.N234_36590 3.97e-20 92.4 COG3344@1|root,COG3344@2|Bacteria,1MVI1@1224|Proteobacteria,2VMDU@28216|Betaproteobacteria,1K21K@119060|Burkholderiaceae 28216|Betaproteobacteria L DNA polymerase - - - - - - - - - - - - GIIM,RVT_1 k59_389094_1 1417296.U879_08080 2.71e-28 110.0 COG0446@1|root,COG1148@1|root,COG0446@2|Bacteria,COG1148@2|Bacteria,1R882@1224|Proteobacteria,2U526@28211|Alphaproteobacteria 28211|Alphaproteobacteria C FAD dependent oxidoreductase - - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 ko:K03388 ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200 M00356,M00357,M00563,M00567 R04540,R11928,R11931,R11943,R11944 RC00011 ko00000,ko00001,ko00002,ko01000 - - - FAD_oxidored,Pyr_redox_2 k59_389094_2 1417296.U879_08075 3.21e-39 142.0 COG2048@1|root,COG2048@2|Bacteria,1R97P@1224|Proteobacteria,2TSIB@28211|Alphaproteobacteria 28211|Alphaproteobacteria C Cysteine-rich domain - - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 ko:K03389 ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200 M00356,M00357,M00563,M00567 R04540,R11928,R11931,R11943,R11944 RC00011 ko00000,ko00001,ko00002,ko01000 - - - CCG k59_551103_2 926569.ANT_00530 6.77e-45 161.0 COG0497@1|root,COG0497@2|Bacteria,2G5V1@200795|Chloroflexi 200795|Chloroflexi L May be involved in recombinational repair of damaged DNA recN - - ko:K03631 - - - - ko00000,ko03400 - - - AAA_23,SMC_N k59_274365_2 1090319.KE386571_gene1603 4.22e-24 100.0 COG1946@1|root,COG1946@2|Bacteria,1MV9R@1224|Proteobacteria,2TRFD@28211|Alphaproteobacteria,2K289@204457|Sphingomonadales 204457|Sphingomonadales I Acyl-CoA thioesterase - - - ko:K10805 ko01040,map01040 - - - ko00000,ko00001,ko01000,ko01004 - - - 4HBT_3 k59_104748_1 436308.Nmar_0063 1.69e-130 383.0 COG0423@1|root,arCOG00405@2157|Archaea,41S8S@651137|Thaumarchaeota 651137|Thaumarchaeota J synthetase (class II) - - 6.1.1.14 ko:K01880 ko00970,map00970 M00359,M00360 R03654 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - HGTP_anticodon,tRNA-synt_2b k59_440029_2 1229909.NSED_00555 4.97e-21 84.3 arCOG10591@1|root,arCOG10591@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_1575816_1 1532557.JL37_16315 1.37e-18 85.5 COG3576@1|root,COG3576@2|Bacteria,1QTUS@1224|Proteobacteria,2VNJ5@28216|Betaproteobacteria,3T5TQ@506|Alcaligenaceae 28216|Betaproteobacteria S Pyridoxamine 5'-phosphate oxidase - - - ko:K07006 - - - - ko00000 - - - Putative_PNPOx k59_1575816_2 997296.PB1_16929 2.78e-37 133.0 COG3448@1|root,COG3448@2|Bacteria,1V4K3@1239|Firmicutes,4HHZV@91061|Bacilli,1ZR53@1386|Bacillus 91061|Bacilli T HPP family - - - - - - - - - - - - HPP k59_1575816_3 194867.ALBQ01000039_gene3071 3.52e-16 85.9 COG2885@1|root,COG3637@1|root,COG2885@2|Bacteria,COG3637@2|Bacteria,1N6EM@1224|Proteobacteria,2U17R@28211|Alphaproteobacteria,2K18P@204457|Sphingomonadales 204457|Sphingomonadales M Belongs to the ompA family - - - - - - - - - - - - OMP_b-brl,OmpA k59_948293_1 349521.HCH_05560 1.68e-76 238.0 COG0596@1|root,COG0596@2|Bacteria,1MUSF@1224|Proteobacteria,1RZNC@1236|Gammaproteobacteria,1XPMR@135619|Oceanospirillales 135619|Oceanospirillales L Alpha beta hydrolase superfamily - - 3.8.1.5 ko:K01563 ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120 - R05284,R05367,R05368,R05369,R05370,R07669,R07670 RC01317,RC01340,RC01341,RC02013 ko00000,ko00001,ko01000 - - - Abhydrolase_1 k59_1683900_1 314287.GB2207_06473 1.15e-98 300.0 COG1066@1|root,COG1066@2|Bacteria,1MUJQ@1224|Proteobacteria,1RN2E@1236|Gammaproteobacteria,1J54Q@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function radA GO:0000725,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009314,GO:0009628,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363 - ko:K04485 - - - - ko00000,ko03400 - - - AAA_25,ATPase,ChlI k59_948297_1 1390370.O203_23385 8.79e-32 125.0 COG3386@1|root,COG3386@2|Bacteria,1P3IB@1224|Proteobacteria 1224|Proteobacteria G PFAM SMP-30 Gluconolaconase - - - - - - - - - - - - SGL k59_1343507_1 330214.NIDE1934 2.58e-05 46.6 COG0477@1|root,COG2814@2|Bacteria,3J0ZP@40117|Nitrospirae 40117|Nitrospirae EGP Acetyl-coenzyme A transporter 1 - - - ko:K08218 ko01501,map01501 M00628 - - ko00000,ko00001,ko00002,ko02000 2.A.1.25 - - MFS_1 k59_1343507_2 1173263.Syn7502_01679 1.53e-25 108.0 COG0726@1|root,COG0726@2|Bacteria,1G2IW@1117|Cyanobacteria,1H1AU@1129|Synechococcus 1117|Cyanobacteria G xylanase chitin deacetylase - - - - - - - - - - - - Polysacc_deac_1 k59_1118041_1 1229909.NSED_09020 3.75e-34 126.0 arCOG10599@1|root,arCOG10599@2157|Archaea 2157|Archaea C copper ion binding - - - - - - - - - - - - - k59_897535_1 391735.Veis_2281 5.03e-28 111.0 COG1414@1|root,COG1414@2|Bacteria,1R7W5@1224|Proteobacteria,2VNWH@28216|Betaproteobacteria,4ADE4@80864|Comamonadaceae 28216|Betaproteobacteria K Bacterial transcriptional regulator - - - - - - - - - - - - HTH_IclR,IclR k59_1343516_1 1122137.AQXF01000002_gene115 3.4e-83 264.0 COG1034@1|root,COG1034@2|Bacteria,1P8MN@1224|Proteobacteria,2TS97@28211|Alphaproteobacteria 28211|Alphaproteobacteria C NADH-quinone oxidoreductase nuoG - 1.6.5.3 ko:K00336 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Fer2_4,Molybdopterin,NADH-G_4Fe-4S_3,NADH_dhqG_C k59_1343516_2 113395.AXAI01000043_gene6076 4.9e-07 50.4 COG1894@1|root,COG1894@2|Bacteria,1MV8F@1224|Proteobacteria,2TRAH@28211|Alphaproteobacteria,3JRII@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain nuoF GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 1.6.5.3 ko:K00335 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_51K,NADH_4Fe-4S,SLBB k59_1456966_1 1111069.TCCBUS3UF1_2850 1.89e-130 382.0 COG4663@1|root,COG4663@2|Bacteria,1WJ6R@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus Q Part of the tripartite ATP-independent periplasmic (TRAP) transport system - - - - - - - - - - - - DctP,TAT_signal k59_1793386_1 999549.KI421513_gene512 4.16e-16 79.7 COG0330@1|root,COG0330@2|Bacteria,1MUM2@1224|Proteobacteria,2TRTP@28211|Alphaproteobacteria,27ZV8@191028|Leisingera 28211|Alphaproteobacteria O SPFH domain / Band 7 family hflK - - ko:K04088 - M00742 - - ko00000,ko00002,ko01000 - - - Band_7,HflK_N k59_1793386_2 1121930.AQXG01000020_gene107 7.07e-93 285.0 COG0330@1|root,COG0330@2|Bacteria,4NHUE@976|Bacteroidetes 976|Bacteroidetes O HflC and HflK could regulate a protease hflC - - ko:K04087 - M00742 - - ko00000,ko00002,ko01000 - - - Band_7 k59_1793386_3 1238184.CM001792_gene2394 1.74e-09 63.5 COG1404@1|root,COG4412@1|root,COG1404@2|Bacteria,COG4412@2|Bacteria,1TPUY@1239|Firmicutes,4HBDE@91061|Bacilli,23J7J@182709|Oceanobacillus 91061|Bacilli O CarboxypepD_reg-like domain bpr GO:0005575,GO:0005576 - ko:K13276 - - - - ko00000,ko01000,ko01002,ko03110 - - - CarbopepD_reg_2,CarboxypepD_reg,Inhibitor_I9,Peptidase_M6,Peptidase_S8 k59_948321_1 702113.PP1Y_AT9635 1.23e-106 316.0 COG2199@1|root,COG3706@2|Bacteria,1NVZM@1224|Proteobacteria,2USQQ@28211|Alphaproteobacteria,2K9Y0@204457|Sphingomonadales 204457|Sphingomonadales T Diguanylate cyclase, GGDEF domain - - - - - - - - - - - - GGDEF,PAS_4 k59_275260_1 1150626.PHAMO_10118 3.11e-21 92.8 COG0352@1|root,COG0352@2|Bacteria,1MZ0K@1224|Proteobacteria,2UA7U@28211|Alphaproteobacteria,2JT3I@204441|Rhodospirillales 204441|Rhodospirillales H Thiamine monophosphate synthase - - 2.5.1.3 ko:K00788 ko00730,ko01100,map00730,map01100 M00127 R03223,R10712 RC00224,RC03255,RC03397 ko00000,ko00001,ko00002,ko01000 - - - TMP-TENI k59_275260_3 1150469.RSPPHO_00285 8.13e-23 95.1 2C2J5@1|root,315UG@2|Bacteria,1RHAH@1224|Proteobacteria,2U94W@28211|Alphaproteobacteria,2JSXP@204441|Rhodospirillales 204441|Rhodospirillales S Domain of unknown function (DUF3576) - - - - - - - - - - - - DUF3576 k59_1177725_1 1229909.NSED_04610 3.57e-39 133.0 arCOG11395@1|root,arCOG11395@2157|Archaea,41TBH@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1177725_2 1229909.NSED_04605 1.01e-45 149.0 arCOG08697@1|root,arCOG08697@2157|Archaea,41SUN@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_160086_1 198214.SF0271 6.1e-157 462.0 COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,1RPM5@1236|Gammaproteobacteria 1236|Gammaproteobacteria I acyl-CoA dehydrogenase fadE GO:0003674,GO:0003824,GO:0003995,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009987,GO:0016020,GO:0016042,GO:0016054,GO:0016491,GO:0016627,GO:0019395,GO:0019752,GO:0030258,GO:0032787,GO:0033539,GO:0034440,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044464,GO:0046395,GO:0055114,GO:0071704,GO:0071944,GO:0072329,GO:1901575 - ko:K06445 ko00071,ko01100,ko01212,map00071,map01100,map01212 M00087 R01175,R01279,R03777,R03857,R03990,R04751,R04754 RC00052,RC00076 ko00000,ko00001,ko00002,ko01000 - - iSbBS512_1146.SbBS512_E0217 Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N,DUF1974 k59_949190_1 977880.RALTA_A1549 5.03e-81 255.0 COG4799@1|root,COG4799@2|Bacteria,1MVAX@1224|Proteobacteria,2VI77@28216|Betaproteobacteria,1K003@119060|Burkholderiaceae 28216|Betaproteobacteria I carboxylase accB - 6.4.1.4 ko:K01969 ko00280,ko01100,map00280,map01100 M00036 R04138 RC00367,RC00942 ko00000,ko00001,ko00002,ko01000 - - - Carboxyl_trans k59_1066047_1 930166.CD58_03495 3.81e-38 145.0 COG4603@1|root,COG4603@2|Bacteria,1MX6V@1224|Proteobacteria,1RS4S@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Belongs to the binding-protein-dependent transport system permease family IV02_22040 - - ko:K02057 - M00221 - - ko00000,ko00002,ko02000 3.A.1.2 - - BPD_transp_2 k59_1519261_1 1249627.D779_2374 2.76e-74 237.0 COG1301@1|root,COG1301@2|Bacteria,1MU0Q@1224|Proteobacteria,1RMEN@1236|Gammaproteobacteria,1WWIC@135613|Chromatiales 135613|Chromatiales U Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family - - - - - - - - - - - - SDF k59_1288134_1 402881.Plav_0955 1.95e-40 149.0 COG0174@1|root,COG0174@2|Bacteria,1MU6V@1224|Proteobacteria,2TTPD@28211|Alphaproteobacteria,1JNAJ@119043|Rhodobiaceae 28211|Alphaproteobacteria E Glutamine synthetase, catalytic domain glnA GO:0003674,GO:0003824,GO:0006576,GO:0006595,GO:0006598,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009308,GO:0009310,GO:0009445,GO:0009447,GO:0009987,GO:0016874,GO:0016879,GO:0016880,GO:0034024,GO:0034641,GO:0042402,GO:0044106,GO:0044237,GO:0071704,GO:0097164,GO:1901564,GO:1901565,GO:1901575 6.3.1.2 ko:K01915 ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 - R00253 RC00010,RC02798 ko00000,ko00001,ko01000,ko04147 - - - Gln-synt_C k59_1288134_2 1192759.AKIB01000026_gene2169 1.74e-22 95.9 COG3670@1|root,COG3670@2|Bacteria,1MY1X@1224|Proteobacteria,2TS7A@28211|Alphaproteobacteria,2K2PY@204457|Sphingomonadales 204457|Sphingomonadales Q Retinal pigment epithelial membrane protein - - - ko:K11159 - - - - ko00000 - - - RPE65 k59_1576765_1 247634.GPB2148_2723 1.98e-57 199.0 COG0612@1|root,COG0612@2|Bacteria,1MVST@1224|Proteobacteria,1RN05@1236|Gammaproteobacteria,1J4IJ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Zn-dependent peptidases pqqL - - ko:K07263 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M16,Peptidase_M16_C k59_1576765_2 56780.SYN_01162 2.72e-35 128.0 COG0428@1|root,COG0428@2|Bacteria,1R40E@1224|Proteobacteria,43B49@68525|delta/epsilon subdivisions,2X6I2@28221|Deltaproteobacteria 28221|Deltaproteobacteria P ZIP Zinc transporter - - - ko:K16267 - - - - ko00000,ko02000 2.A.5.4.11 - - Zip k59_160100_1 1163407.UU7_13868 3.91e-22 97.4 COG1215@1|root,COG1215@2|Bacteria,1QU92@1224|Proteobacteria 1224|Proteobacteria M Glycosyl transferase family 2 - - - - - - - - - - - - Glycos_transf_2 k59_1629559_1 1207063.P24_03610 8.67e-95 281.0 COG1028@1|root,COG1028@2|Bacteria,1MUEV@1224|Proteobacteria,2TRCF@28211|Alphaproteobacteria,2JQTW@204441|Rhodospirillales 204441|Rhodospirillales IQ COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) phbB - 1.1.1.100,1.1.1.36 ko:K00023,ko:K00059 ko00061,ko00333,ko00630,ko00650,ko00780,ko01040,ko01100,ko01120,ko01130,ko01200,ko01212,map00061,map00333,map00630,map00650,map00780,map01040,map01100,map01120,map01130,map01200,map01212 M00083,M00373,M00572 R01779,R01977,R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00103,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 k59_1629559_2 34740.HMEL012370-PA 5.54e-05 45.8 COG1028@1|root,KOG4169@2759|Eukaryota,39MT4@33154|Opisthokonta,3BJE1@33208|Metazoa,3D0NN@33213|Bilateria,42213@6656|Arthropoda,3SZWI@50557|Insecta,44B25@7088|Lepidoptera 33208|Metazoa Q Enoyl-(Acyl carrier protein) reductase HPGD GO:0000003,GO:0000166,GO:0001568,GO:0001655,GO:0001676,GO:0001822,GO:0001944,GO:0002237,GO:0003674,GO:0003824,GO:0004888,GO:0004930,GO:0004953,GO:0004954,GO:0004955,GO:0004957,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005615,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0006636,GO:0006690,GO:0006692,GO:0006693,GO:0007154,GO:0007165,GO:0007166,GO:0007167,GO:0007178,GO:0007179,GO:0007186,GO:0007275,GO:0007276,GO:0007292,GO:0007565,GO:0007567,GO:0008150,GO:0008152,GO:0008284,GO:0008610,GO:0009058,GO:0009605,GO:0009607,GO:0009617,GO:0009636,GO:0009653,GO:0009719,GO:0009725,GO:0009987,GO:0010033,GO:0010941,GO:0010942,GO:0014070,GO:0016053,GO:0016404,GO:0016491,GO:0016614,GO:0016616,GO:0019372,GO:0019752,GO:0019953,GO:0022414,GO:0023052,GO:0030728,GO:0031974,GO:0031981,GO:0032355,GO:0032496,GO:0032501,GO:0032502,GO:0032504,GO:0032787,GO:0033559,GO:0033993,GO:0035239,GO:0035295,GO:0036094,GO:0038023,GO:0042127,GO:0042221,GO:0042493,GO:0042759,GO:0042802,GO:0042803,GO:0042981,GO:0043065,GO:0043067,GO:0043068,GO:0043167,GO:0043168,GO:0043207,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044421,GO:0044422,GO:0044424,GO:0044428,GO:0044444,GO:0044446,GO:0044464,GO:0044703,GO:0044706,GO:0045471,GO:0045786,GO:0046394,GO:0046456,GO:0046677,GO:0046983,GO:0048037,GO:0048513,GO:0048514,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048609,GO:0048660,GO:0048661,GO:0048731,GO:0048844,GO:0048856,GO:0050662,GO:0050789,GO:0050794,GO:0050896,GO:0051287,GO:0051704,GO:0051707,GO:0051716,GO:0051726,GO:0055114,GO:0060089,GO:0060840,GO:0065007,GO:0070013,GO:0070403,GO:0070493,GO:0070848,GO:0070887,GO:0071310,GO:0071363,GO:0071495,GO:0071559,GO:0071560,GO:0071704,GO:0072001,GO:0072330,GO:0072358,GO:0072359,GO:0097070,GO:0097159,GO:0097305,GO:1901265,GO:1901363,GO:1901568,GO:1901570,GO:1901576,GO:1901700,GO:1904705,GO:1904707,GO:2001300,GO:2001301 1.1.1.141 ko:K00069 ko05202,map05202 - - - ko00000,ko00001,ko01000,ko04147 - - - adh_short k59_837974_1 768671.ThimaDRAFT_2361 2.45e-73 234.0 COG0569@1|root,COG0569@2|Bacteria,1MW8R@1224|Proteobacteria,1RNVQ@1236|Gammaproteobacteria,1WVX7@135613|Chromatiales 135613|Chromatiales P PFAM TrkA-N domain trkA - - ko:K03499 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - - TrkA_C,TrkA_N k59_837974_2 1123393.KB891332_gene2756 6.19e-06 45.4 COG0168@1|root,COG0168@2|Bacteria 2|Bacteria P Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA trkH - - ko:K03498 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - - TrkH k59_1004809_1 1122137.AQXF01000003_gene2379 1.94e-79 237.0 COG0229@1|root,COG0229@2|Bacteria,1RGWC@1224|Proteobacteria,2U70T@28211|Alphaproteobacteria 28211|Alphaproteobacteria O methionine sulfoxide reductase msrB - 1.8.4.12 ko:K07305 - - - - ko00000,ko01000 - - - SelR k59_1118889_1 1415778.JQMM01000001_gene639 1.99e-56 185.0 COG2805@1|root,COG2805@2|Bacteria,1MU3J@1224|Proteobacteria,1RN8G@1236|Gammaproteobacteria,1J4KJ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria NU Tfp pilus assembly protein, pilus retraction ATPase PilT pilT GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - ko:K02669 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE k59_1118889_2 864565.HMPREF0379_0178 4.03e-10 60.8 COG2805@1|root,COG2805@2|Bacteria,1TQ5F@1239|Firmicutes,249H9@186801|Clostridia 186801|Clostridia NU twitching motility protein pilT - - ko:K02669 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE k59_1066082_1 266264.Rmet_4862 1.95e-28 104.0 COG2329@1|root,COG2329@2|Bacteria,1N078@1224|Proteobacteria,2VSX8@28216|Betaproteobacteria,1K8F7@119060|Burkholderiaceae 28216|Betaproteobacteria S Antibiotic biosynthesis monooxygenase - - - - - - - - - - - - ABM k59_1066082_2 1207055.C100_16835 2.49e-42 148.0 COG0451@1|root,COG0451@2|Bacteria,1MU1A@1224|Proteobacteria,2TU1A@28211|Alphaproteobacteria,2K47P@204457|Sphingomonadales 204457|Sphingomonadales GM RmlD substrate binding domain - - - - - - - - - - - - Epimerase k59_728399_1 1247726.MIM_c17880 2.56e-110 329.0 COG0821@1|root,COG0821@2|Bacteria,1MUAX@1224|Proteobacteria,2VID7@28216|Betaproteobacteria,3T1KN@506|Alcaligenaceae 28216|Betaproteobacteria I Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate ispG - 1.17.7.1,1.17.7.3 ko:K03526 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R08689,R10859 RC01486 ko00000,ko00001,ko00002,ko01000 - - - GcpE k59_1288157_1 402881.Plav_0002 2.56e-43 146.0 COG0607@1|root,COG0607@2|Bacteria,1REHH@1224|Proteobacteria,2UBVU@28211|Alphaproteobacteria,1JP2H@119043|Rhodobiaceae 28211|Alphaproteobacteria P Rhodanese Homology Domain pspE - - - - - - - - - - - Rhodanese k59_1288157_2 1380393.JHVP01000004_gene401 7.08e-05 44.7 COG5416@1|root,COG5416@2|Bacteria,2HD5K@201174|Actinobacteria 201174|Actinobacteria S Lipopolysaccharide assembly protein A domain - - - - - - - - - - - - LapA_dom k59_1576780_1 1454004.AW11_02281 2.32e-07 54.7 COG0318@1|root,COG0318@2|Bacteria,1MW0Y@1224|Proteobacteria,2VPB2@28216|Betaproteobacteria 28216|Betaproteobacteria IQ AMP-binding enzyme C-terminal domain menE - 6.2.1.26 ko:K01911 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116 R04030 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000 - - - AMP-binding,AMP-binding_C k59_1576780_2 1001585.MDS_3658 5.48e-14 71.6 COG0789@1|root,COG0789@2|Bacteria,1N1YK@1224|Proteobacteria,1RPG2@1236|Gammaproteobacteria,1YEU9@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria K helix_turn_helix, mercury resistance - - - - - - - - - - - - MerR_1 k59_898434_1 1202532.FF52_00060 8.31e-98 297.0 COG1312@1|root,COG1312@2|Bacteria,4NFA5@976|Bacteroidetes,1HY45@117743|Flavobacteriia,2NTTU@237|Flavobacterium 976|Bacteroidetes G Catalyzes the dehydration of D-mannonate uxuA GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0005975,GO:0005996,GO:0006063,GO:0006064,GO:0006082,GO:0008150,GO:0008152,GO:0008198,GO:0008927,GO:0009056,GO:0009987,GO:0016052,GO:0016054,GO:0016829,GO:0016835,GO:0016836,GO:0019585,GO:0019752,GO:0030145,GO:0032787,GO:0042839,GO:0042840,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0046365,GO:0046395,GO:0046872,GO:0046914,GO:0071704,GO:0072329,GO:1901575 4.2.1.8 ko:K01686 ko00040,ko01100,map00040,map01100 M00061 R05606 RC00543 ko00000,ko00001,ko00002,ko01000 - - - UxuA k59_1629573_1 1552758.NC00_03110 6.94e-116 354.0 COG0419@1|root,COG0419@2|Bacteria,1R5QS@1224|Proteobacteria,1RRME@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Protein of unknown function (DUF3732) - - - - - - - - - - - - AAA_23,DUF3732 k59_1519290_1 391603.FBALC1_17157 3.01e-106 311.0 COG2932@1|root,COG2932@2|Bacteria,4NDUW@976|Bacteroidetes,1HYBJ@117743|Flavobacteriia 976|Bacteroidetes K transcriptional regulator - - - - - - - - - - - - HTH_19,HTH_3,Peptidase_S24 k59_667322_2 379731.PST_3347 8.98e-119 344.0 COG2801@1|root,COG2801@2|Bacteria,1MVN5@1224|Proteobacteria,1RP6D@1236|Gammaproteobacteria,1Z4DU@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria L Integrase core domain - - - ko:K07497 - - - - ko00000 - - - rve,rve_3 k59_778617_1 316407.4062544 4.23e-119 358.0 COG4775@1|root,COG4775@2|Bacteria,1MX3H@1224|Proteobacteria,1RQKV@1236|Gammaproteobacteria,3XMA1@561|Escherichia 1236|Gammaproteobacteria M extracellular polysaccharide metabolic process wbfB GO:0000271,GO:0005975,GO:0005976,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016051,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0045226,GO:0046379,GO:0071704,GO:1901576 - - - - - - - - - - YjbH k59_1519296_1 158500.BV97_01057 5.74e-87 270.0 COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,2TRYI@28211|Alphaproteobacteria,2K0VP@204457|Sphingomonadales 204457|Sphingomonadales C FAD linked - - - - - - - - - - - - FAD-oxidase_C,FAD_binding_4 k59_615090_1 402777.KB235904_gene3963 3.75e-35 139.0 COG2202@1|root,COG4251@1|root,COG5278@1|root,COG2202@2|Bacteria,COG4251@2|Bacteria,COG5278@2|Bacteria,1G0A1@1117|Cyanobacteria,1H7JR@1150|Oscillatoriales 1117|Cyanobacteria T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - CHASE3,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9 k59_615090_2 358396.C445_04493 2.17e-34 139.0 COG0642@1|root,arCOG02330@1|root,arCOG02348@1|root,arCOG02330@2157|Archaea,arCOG02348@2157|Archaea,arCOG02358@2157|Archaea,2Y7KE@28890|Euryarchaeota,240TZ@183963|Halobacteria 183963|Halobacteria T Histidine kinase - - - - - - - - - - - - GAF_2,HATPase_c,HisKA,PAS_4 k59_49760_1 382464.ABSI01000012_gene2201 9.89e-29 120.0 COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria 2|Bacteria S cAMP biosynthetic process - - - - - - - - - - - - BTAD,TPR_11,TPR_16,TPR_7,TPR_8,Trans_reg_C k59_1629593_1 247633.GP2143_15761 2.64e-75 240.0 COG1612@1|root,COG1612@2|Bacteria,1MVJ4@1224|Proteobacteria,1RQWB@1236|Gammaproteobacteria,1J5KM@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O protein required for cytochrome oxidase assembly ctaA - - ko:K02259 ko00190,ko00860,ko01100,ko01110,ko02020,ko04714,map00190,map00860,map01100,map01110,map02020,map04714 M00154 R07412 RC00769 ko00000,ko00001,ko00002,ko03029 3.D.4.4 - - COX15-CtaA k59_1177771_1 1122137.AQXF01000001_gene3290 3.93e-40 135.0 COG1396@1|root,COG1396@2|Bacteria,1N1CT@1224|Proteobacteria,2UCMF@28211|Alphaproteobacteria 28211|Alphaproteobacteria K Transcriptional - - - - - - - - - - - - HTH_3,HTH_31 k59_1177771_2 203122.Sde_3699 6.39e-21 91.7 COG3004@1|root,COG3004@2|Bacteria,1MW15@1224|Proteobacteria,1RNDE@1236|Gammaproteobacteria,465KF@72275|Alteromonadaceae 1236|Gammaproteobacteria P Na( ) H( ) antiporter that extrudes sodium in exchange for external protons nhaA - - ko:K03313 - - - - ko00000,ko02000 2.A.33.1 - - Na_H_antiport_1 k59_1118908_1 1455608.JDTH01000011_gene2339 3.69e-35 134.0 COG2217@1|root,arCOG01576@2157|Archaea,2XTD8@28890|Euryarchaeota,23SNP@183963|Halobacteria 183963|Halobacteria P COG2217 Cation transport ATPase - - 3.6.3.3,3.6.3.5 ko:K01534 - - - - ko00000,ko01000 3.A.3.6 - - E1-E2_ATPase,HMA,Hydrolase k59_1118908_2 1168034.FH5T_18155 2.81e-15 74.7 COG0667@1|root,COG0667@2|Bacteria,4NEB0@976|Bacteroidetes,2FMYE@200643|Bacteroidia 976|Bacteroidetes C aldo keto reductase - - - - - - - - - - - - Aldo_ket_red k59_898455_1 522306.CAP2UW1_0623 2.66e-82 258.0 COG3266@1|root,COG3267@1|root,COG3266@2|Bacteria,COG3267@2|Bacteria,1MU3G@1224|Proteobacteria,2VMD2@28216|Betaproteobacteria 28216|Betaproteobacteria U AAA domain exeA1 - - - - - - - - - - - AAA_22,SPOR k59_1457876_1 1121459.AQXE01000003_gene1149 6.09e-64 209.0 COG1760@1|root,COG1760@2|Bacteria,1MUZN@1224|Proteobacteria,42N88@68525|delta/epsilon subdivisions,2WISX@28221|Deltaproteobacteria,2M8PI@213115|Desulfovibrionales 28221|Deltaproteobacteria E PFAM serine dehydratase alpha chain - - 4.3.1.17 ko:K01752 ko00260,ko00270,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00270,map01100,map01110,map01130,map01200,map01230 - R00220,R00590 RC00331,RC02600 ko00000,ko00001,ko01000 - - - SDH_alpha,SDH_beta k59_49777_1 1121937.AUHJ01000007_gene1784 6.14e-114 337.0 COG0004@1|root,COG0004@2|Bacteria,1NR9F@1224|Proteobacteria,1RNKF@1236|Gammaproteobacteria,4652P@72275|Alteromonadaceae 1236|Gammaproteobacteria P Ammonium transporter amtB - - ko:K03320 - - - - ko00000,ko02000 1.A.11 - - Ammonium_transp k59_1576841_1 1121374.KB891586_gene2439 4.32e-44 169.0 COG4774@1|root,COG4774@2|Bacteria,1QXWU@1224|Proteobacteria,1T3IF@1236|Gammaproteobacteria 1236|Gammaproteobacteria P TonB dependent receptor - - - - - - - - - - - - Plug,TonB_dep_Rec k59_1004866_1 762376.AXYL_04515 4.85e-69 220.0 COG3181@1|root,COG3181@2|Bacteria,1P88K@1224|Proteobacteria,2VJJP@28216|Betaproteobacteria,3T1V0@506|Alcaligenaceae 28216|Betaproteobacteria S Tripartite tricarboxylate transporter family receptor - - - - - - - - - - - - TctC k59_390156_1 349124.Hhal_0063 1.01e-14 77.0 COG4659@1|root,COG4659@2|Bacteria,1R6FE@1224|Proteobacteria,1RYZ7@1236|Gammaproteobacteria,1WXWE@135613|Chromatiales 135613|Chromatiales U Part of a membrane complex involved in electron transport - - - ko:K03612 - - - - ko00000 - - - FMN_bind k59_1233646_1 1313172.YM304_01570 2.47e-71 227.0 COG0402@1|root,COG0402@2|Bacteria,2ISY0@201174|Actinobacteria 201174|Actinobacteria F Amidohydrolase family - - - - - - - - - - - - Amidohydro_1 k59_1519327_1 867900.Celly_1649 6.19e-149 435.0 COG1154@1|root,COG1154@2|Bacteria,4NDY5@976|Bacteroidetes,1HYDB@117743|Flavobacteriia,1F8QJ@104264|Cellulophaga 976|Bacteroidetes H Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) dxs - 2.2.1.7 ko:K01662 ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130 M00096 R05636 RC00032 ko00000,ko00001,ko00002,ko01000 - - - DXP_synthase_N,E1_dh,Transket_pyr,Transketolase_C k59_496442_1 1265503.KB905171_gene498 5.23e-10 66.2 COG5616@1|root,COG5616@2|Bacteria,1NSKC@1224|Proteobacteria,1S0KQ@1236|Gammaproteobacteria 1236|Gammaproteobacteria S cAMP biosynthetic process - - - - - - - - - - - - - k59_332998_1 1003200.AXXA_28670 2.69e-66 237.0 COG3210@1|root,COG3210@2|Bacteria,1QVC2@1224|Proteobacteria,2VSG1@28216|Betaproteobacteria 28216|Betaproteobacteria U domain, Protein - - - - - - - - - - - - Haemagg_act,VPEP k59_1576850_2 1429916.X566_23815 1.03e-41 144.0 COG3917@1|root,COG3917@2|Bacteria,1RDNQ@1224|Proteobacteria,2VGB4@28211|Alphaproteobacteria,3JSB7@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria Q 2-hydroxychromene-2-carboxylate isomerase MA20_32385 - - - - - - - - - - - DSBA k59_275349_1 1235794.C811_00606 1.93e-42 145.0 COG1327@1|root,COG1327@2|Bacteria,2IHU9@201174|Actinobacteria,4CVYF@84998|Coriobacteriia 84998|Coriobacteriia K Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes nrdR - - ko:K07738 - - - - ko00000,ko03000 - - - ATP-cone k59_49812_1 319003.Bra1253DRAFT_05154 1.34e-34 124.0 COG2801@1|root,COG2801@2|Bacteria,1N207@1224|Proteobacteria,2U1EH@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Homeodomain-like domain - - - - - - - - - - - - HTH_32,rve,rve_3 k59_1684879_2 1229909.NSED_00815 1.06e-47 154.0 arCOG10520@1|root,arCOG10520@2157|Archaea,41T7W@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1684879_3 436308.Nmar_0204 5.92e-40 136.0 arCOG10529@1|root,arCOG10529@2157|Archaea,41SSF@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_615127_1 1090318.ATTI01000001_gene3064 6.11e-14 73.6 COG0635@1|root,COG0635@2|Bacteria,1MU76@1224|Proteobacteria,2TT63@28211|Alphaproteobacteria,2K09I@204457|Sphingomonadales 204457|Sphingomonadales H Involved in the biosynthesis of porphyrin-containing compound - - - - - - - - - - - - HemN_C,Radical_SAM k59_615127_2 331869.BAL199_11226 2.26e-64 216.0 COG0683@1|root,COG0683@2|Bacteria,1QURG@1224|Proteobacteria,2TS62@28211|Alphaproteobacteria,4BQ8V@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria E Periplasmic binding protein MA20_24635 - - - - - - - - - - - Peripla_BP_6 k59_949294_1 1122137.AQXF01000005_gene1022 4.15e-129 381.0 COG2850@1|root,COG2850@2|Bacteria 2|Bacteria P peptidyl-arginine hydroxylation - - - - - - - - - - - - Cupin_4 k59_949294_2 392499.Swit_1306 1.29e-19 86.7 COG2266@1|root,COG2266@2|Bacteria,1RFQ8@1224|Proteobacteria,2U7WE@28211|Alphaproteobacteria,2KEM1@204457|Sphingomonadales 204457|Sphingomonadales H MobA-like NTP transferase domain - - - - - - - - - - - - NTP_transf_3 k59_1074486_1 391603.FBALC1_00842 9.67e-106 325.0 COG0370@1|root,COG0370@2|Bacteria,4NEII@976|Bacteroidetes,1HXDK@117743|Flavobacteriia 976|Bacteroidetes P transporter of a GTP-driven Fe(2 ) uptake system feoB - - ko:K04759 - - - - ko00000,ko02000 9.A.8.1 - - FeoA,FeoB_C,FeoB_N,Gate k59_227232_1 555793.WSK_0438 2.55e-100 294.0 COG1611@1|root,COG1611@2|Bacteria,1RD59@1224|Proteobacteria,2U5DP@28211|Alphaproteobacteria,2K4X8@204457|Sphingomonadales 204457|Sphingomonadales S Belongs to the LOG family - - 3.2.2.10 ko:K06966 ko00230,ko00240,map00230,map00240 - R00182,R00510 RC00063,RC00318 ko00000,ko00001,ko01000 - - - Lysine_decarbox k59_1131234_1 1026882.MAMP_01427 1.43e-34 128.0 COG4582@1|root,COG4582@2|Bacteria,1MW69@1224|Proteobacteria,1RNPD@1236|Gammaproteobacteria,460VI@72273|Thiotrichales 72273|Thiotrichales D Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity zapD - - ko:K18778 - - - - ko00000,ko03036 - - - ZapD k59_1357204_1 1144313.PMI10_02243 7.73e-43 159.0 COG3291@1|root,COG3291@2|Bacteria,4NDZC@976|Bacteroidetes,1HY1V@117743|Flavobacteriia,2P0KB@237|Flavobacterium 976|Bacteroidetes M Repeats in polycystic kidney disease 1 (PKD1) and other proteins - - - - - - - - - - - - CHU_C,PKD,SprB k59_396757_1 596151.DesfrDRAFT_0590 1.17e-118 366.0 COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,42M9W@68525|delta/epsilon subdivisions,2WJ29@28221|Deltaproteobacteria,2M832@213115|Desulfovibrionales 28221|Deltaproteobacteria O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner lon-3 - 3.4.21.53 ko:K01338 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - AAA,LON_substr_bdg,Lon_C k59_284011_1 330214.NIDE3562 5.13e-36 130.0 COG0039@1|root,COG0039@2|Bacteria,3J0EG@40117|Nitrospirae 40117|Nitrospirae C Catalyzes the reversible oxidation of malate to oxaloacetate mdh - 1.1.1.37 ko:K00024 ko00020,ko00270,ko00620,ko00630,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00270,map00620,map00630,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740 R00342,R07136 RC00031 ko00000,ko00001,ko00002,ko01000 - - - Ldh_1_C,Ldh_1_N k59_1244217_1 861299.J421_2862 7.6e-95 291.0 COG0499@1|root,COG0499@2|Bacteria,1ZTEF@142182|Gemmatimonadetes 142182|Gemmatimonadetes H May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine ahcY - 3.3.1.1 ko:K01251 ko00270,ko01100,map00270,map01100 M00035 R00192,R04936 RC00056,RC00069,RC01161,RC01243 ko00000,ko00001,ko00002,ko01000,ko01009,ko04147 - - - AdoHcyase,AdoHcyase_NAD k59_961616_1 156889.Mmc1_3646 2.36e-18 82.8 COG3298@1|root,COG3298@2|Bacteria,1MVZJ@1224|Proteobacteria 1224|Proteobacteria L 3'-5' exonuclease related to the exonuclease domain of PolB wlaX - - ko:K07501 - - - - ko00000 - - - DNA_pol_B_exo2 k59_961616_2 472759.Nhal_0141 1.47e-56 189.0 COG3930@1|root,COG3930@2|Bacteria,1PYFH@1224|Proteobacteria,1RP1J@1236|Gammaproteobacteria,1WYBF@135613|Chromatiales 135613|Chromatiales S DUF1704 - - - - - - - - - - - - DUF1704 k59_1246_1 207559.Dde_0636 3.4e-65 213.0 COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,42M9N@68525|delta/epsilon subdivisions,2WIZR@28221|Deltaproteobacteria,2M9FR@213115|Desulfovibrionales 28221|Deltaproteobacteria G PFAM TRAP C4-dicarboxylate transport system permease DctM subunit - - - - - - - - - - - - DctM k59_679225_2 944564.HMPREF9200_1479 4.12e-45 151.0 COG1490@1|root,COG1490@2|Bacteria,1V6GH@1239|Firmicutes 1239|Firmicutes J rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality dtd GO:0002161,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006399,GO:0006450,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0034641,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0051499,GO:0051500,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360 - ko:K07560 - - - - ko00000,ko01000,ko03016 - - - Tyr_Deacylase k59_679225_3 479434.Sthe_3238 2.92e-40 138.0 COG0717@1|root,COG0717@2|Bacteria,2GBA2@200795|Chloroflexi,27Y8U@189775|Thermomicrobia 189775|Thermomicrobia F dUTPase - - 3.5.4.13 ko:K01494 ko00240,ko01100,map00240,map01100 M00053 R00568,R02325 RC00074 ko00000,ko00001,ko00002,ko01000 - - - dUTPase k59_227246_2 926550.CLDAP_02040 2.06e-128 384.0 COG3385@1|root,COG3385@2|Bacteria,2G7UE@200795|Chloroflexi 200795|Chloroflexi L transposase activity - - - - - - - - - - - - - k59_509708_1 314282.PCNPT3_07010 4.53e-46 165.0 COG0641@1|root,COG0641@2|Bacteria,1MX3M@1224|Proteobacteria,1RN4R@1236|Gammaproteobacteria 1236|Gammaproteobacteria C radical SAM domain protein aslB - - ko:K06871 - - - - ko00000 - - - Fer4_12,Radical_SAM,SPASM k59_1526643_1 436308.Nmar_1203 6.16e-73 228.0 arCOG10580@1|root,arCOG10580@2157|Archaea 436308.Nmar_1203|- - - - - - - - - - - - - - - - k59_735845_1 1122137.AQXF01000002_gene395 2.88e-115 335.0 COG0293@1|root,COG0293@2|Bacteria,1MW1C@1224|Proteobacteria,2TSBW@28211|Alphaproteobacteria 28211|Alphaproteobacteria J Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit ftsJ - 2.1.1.166 ko:K02427 - - - - ko00000,ko01000,ko03009 - - - FtsJ k59_735845_2 1122137.AQXF01000002_gene394 8.5e-317 867.0 COG0516@1|root,COG0517@1|root,COG0516@2|Bacteria,COG0517@2|Bacteria,1MUJM@1224|Proteobacteria,2TQXC@28211|Alphaproteobacteria 28211|Alphaproteobacteria F Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth guaB GO:0003674,GO:0003824,GO:0003938,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006183,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046039,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 1.1.1.205,1.7.1.7 ko:K00088,ko:K00364 ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 M00050 R01130,R01134,R08240 RC00143,RC00457,RC02207 ko00000,ko00001,ko00002,ko01000,ko04147 - - - CBS,IMPDH,NMO k59_735845_3 1122137.AQXF01000002_gene393 1.05e-76 246.0 COG0144@1|root,COG0144@2|Bacteria,1MV2Q@1224|Proteobacteria,2TS6U@28211|Alphaproteobacteria 28211|Alphaproteobacteria J Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB NOP family sun1 - 2.1.1.176 ko:K03500 - - - - ko00000,ko01000,ko03009 - - - Methyltr_RsmB-F k59_905083_1 1229909.NSED_06845 4.16e-120 353.0 COG0644@1|root,arCOG00570@2157|Archaea,41SB5@651137|Thaumarchaeota 651137|Thaumarchaeota C Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains - - - - - - - - - - - - - k59_396790_1 342610.Patl_0853 8.5e-71 229.0 COG0583@1|root,COG0583@2|Bacteria,1PEF2@1224|Proteobacteria,1RS7V@1236|Gammaproteobacteria,2Q5E8@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria K PFAM regulatory protein, LysR LysR, substrate-binding - - - - - - - - - - - - HTH_1,LysR_substrate k59_396790_2 46429.BV95_02268 0.000306 47.4 COG1629@1|root,COG4771@2|Bacteria,1MWKN@1224|Proteobacteria,2U3JH@28211|Alphaproteobacteria,2K1GK@204457|Sphingomonadales 204457|Sphingomonadales P receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_566392_1 330214.NIDE1362 2.39e-116 360.0 COG2844@1|root,COG2844@2|Bacteria 2|Bacteria O Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen glnD - 2.7.7.42,2.7.7.59,2.7.7.89 ko:K00982,ko:K00990 ko02020,map02020 - - - ko00000,ko00001,ko01000 - - - ACT,GlnD_UR_UTase,HD,NTP_transf_2 k59_1074530_1 441620.Mpop_2366 3.08e-15 81.3 COG2207@1|root,COG2207@2|Bacteria,1Q1II@1224|Proteobacteria,2TUE0@28211|Alphaproteobacteria,1JTDS@119045|Methylobacteriaceae 28211|Alphaproteobacteria K PFAM helix-turn-helix- domain containing protein AraC type - - - - - - - - - - - - AraC_binding_2,HTH_18 k59_1752589_1 573370.DMR_14920 3.33e-90 276.0 COG0112@1|root,COG0112@2|Bacteria,1MUIS@1224|Proteobacteria,42M0T@68525|delta/epsilon subdivisions,2WJ3C@28221|Deltaproteobacteria,2M9J9@213115|Desulfovibrionales 28221|Deltaproteobacteria E Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism glyA - 2.1.2.1 ko:K00600 ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523 M00140,M00141,M00346,M00532 R00945,R09099 RC00022,RC00112,RC01583,RC02958 ko00000,ko00001,ko00002,ko01000 - - - SHMT k59_1131272_1 1121405.dsmv_0026 1.4e-53 172.0 COG2050@1|root,COG2050@2|Bacteria,1RBPE@1224|Proteobacteria,42RKY@68525|delta/epsilon subdivisions,2WNSM@28221|Deltaproteobacteria,2MJZR@213118|Desulfobacterales 28221|Deltaproteobacteria Q Thioesterase superfamily - - - - - - - - - - - - 4HBT k59_622710_1 488538.SAR116_0446 4.9e-84 258.0 COG0031@1|root,COG0031@2|Bacteria,1MUBE@1224|Proteobacteria,2TR4W@28211|Alphaproteobacteria,4BPH1@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria E Pyridoxal-phosphate dependent enzyme cysB - 2.5.1.47 ko:K01738 ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230 M00021 R00897,R03601,R04859 RC00020,RC02814,RC02821 ko00000,ko00001,ko00002,ko01000 - - - PALP k59_1752592_1 1120977.JHUX01000007_gene232 4.34e-08 58.9 COG4969@1|root,COG4969@2|Bacteria,1N6M1@1224|Proteobacteria,1SKQY@1236|Gammaproteobacteria,3NQRJ@468|Moraxellaceae 1236|Gammaproteobacteria NU Protein of unknown function (DUF2628) - - - - - - - - - - - - DUF2628,Pilin k59_1752592_2 395493.BegalDRAFT_2164 5.87e-24 101.0 COG1721@1|root,COG1721@2|Bacteria,1MXDI@1224|Proteobacteria,1RQSS@1236|Gammaproteobacteria 1236|Gammaproteobacteria S conserved protein (some members contain a von Willebrand factor type A (vWA) domain) - - - - - - - - - - - - DUF58 k59_509737_1 1168065.DOK_11279 4.09e-29 115.0 COG0195@1|root,COG0195@2|Bacteria,1MWT7@1224|Proteobacteria,1RNQS@1236|Gammaproteobacteria,1J4C0@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria K Participates in both transcription termination and antitermination nusA GO:0001000,GO:0001121,GO:0001125,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006353,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0019899,GO:0019904,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043175,GO:0043244,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0070063,GO:0071704,GO:0080090,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576,GO:1903506,GO:2000112,GO:2001141 - ko:K02600 - - - - ko00000,ko03009,ko03021 - - - HHH_5,KH_5,NusA_N,S1 k59_509737_2 1415778.JQMM01000001_gene1016 2.65e-40 152.0 COG0532@1|root,COG0532@2|Bacteria,1MV26@1224|Proteobacteria,1RM9X@1236|Gammaproteobacteria,1J4HS@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex infB GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003676,GO:0003723,GO:0003743,GO:0003824,GO:0003924,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006413,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019538,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034641,GO:0034645,GO:0036094,GO:0043021,GO:0043024,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0097159,GO:0097216,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - ko:K02519 - - - - ko00000,ko03012,ko03029 - - - GTP_EFTU,GTP_EFTU_D2,IF-2,IF2_N,IF2_assoc k59_1696113_1 455436.DS989813_gene1111 5.12e-10 61.6 COG0845@1|root,COG0845@2|Bacteria,1MUFW@1224|Proteobacteria,1RQJ9@1236|Gammaproteobacteria,466HH@72275|Alteromonadaceae 1236|Gammaproteobacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - ko:K03585 ko01501,ko01503,map01501,map01503 M00646,M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000,ko03036 2.A.6.2,8.A.1.6 - - HlyD_D23 k59_1696113_2 1120953.AUBH01000002_gene1378 2.23e-45 164.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,4648N@72275|Alteromonadaceae 1236|Gammaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family acrF - - ko:K18138 ko01501,ko01503,map01501,map01503 M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000 2.A.6.2 - - ACR_tran k59_57996_1 247633.GP2143_04995 4.77e-24 96.3 COG0745@1|root,COG0745@2|Bacteria,1N0YI@1224|Proteobacteria,1RPNH@1236|Gammaproteobacteria,1JBYT@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain qseB - - ko:K02483,ko:K07666 ko02020,ko02024,map02020,map02024 M00453 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Trans_reg_C k59_566410_1 519989.ECTPHS_07331 2.24e-68 233.0 COG0567@1|root,COG0567@2|Bacteria,1MVBF@1224|Proteobacteria,1RN8K@1236|Gammaproteobacteria,1WWM2@135613|Chromatiales 135613|Chromatiales C Dehydrogenase E1 component sucA - 1.2.4.2 ko:K00164 ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00032 R00621,R01933,R01940,R03316,R08549 RC00004,RC00027,RC00627,RC02743,RC02833,RC02883 br01601,ko00000,ko00001,ko00002,ko01000 - - - 2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr k59_1470297_1 1380355.JNIJ01000029_gene3099 1.88e-11 70.1 COG0515@1|root,COG2203@1|root,COG3899@1|root,COG4191@1|root,COG0515@2|Bacteria,COG2203@2|Bacteria,COG3899@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TR8X@28211|Alphaproteobacteria,3JR6P@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria T Histidine kinase fixL - 2.7.13.3 ko:K14986 ko02020,map02020 M00524 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - AAA_16,CHASE3,DUF4118,GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_9 k59_284090_2 509190.Cseg_2406 4.89e-19 89.0 COG3670@1|root,COG3670@2|Bacteria,1MY1X@1224|Proteobacteria,2TS7A@28211|Alphaproteobacteria 28211|Alphaproteobacteria Q dioxygenase - - 1.13.11.82 ko:K11159,ko:K21822 - - - - ko00000,ko01000 - - - RPE65 k59_1244288_1 95619.PM1_0204750 1.97e-90 284.0 COG0323@1|root,COG0323@2|Bacteria,1MV61@1224|Proteobacteria,1RM89@1236|Gammaproteobacteria 1236|Gammaproteobacteria L This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex mutL GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - ko:K03572 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - DNA_mis_repair,HATPase_c_3,MutL_C k59_735890_1 1122176.KB903540_gene104 5.21e-23 104.0 COG2866@1|root,COG2866@2|Bacteria,4NEJA@976|Bacteroidetes,1IUTX@117747|Sphingobacteriia 976|Bacteroidetes E Zinc carboxypeptidase - - - - - - - - - - - - Peptidase_M14 k59_961694_1 1056820.KB900629_gene1754 5e-79 244.0 COG0463@1|root,COG0463@2|Bacteria,1MWE5@1224|Proteobacteria,1RPCE@1236|Gammaproteobacteria,2PNHF@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria M Glycosyltransferase like family 2 gtrB GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K20534 - - - - ko00000,ko01000,ko01005,ko02000 4.D.2.1.9 GT2 - Glycos_transf_2 k59_1300954_1 1120999.JONM01000008_gene2022 2.12e-34 128.0 COG3471@1|root,COG3471@2|Bacteria,1MZA2@1224|Proteobacteria,2VQW2@28216|Betaproteobacteria,2KTZU@206351|Neisseriales 206351|Neisseriales S Protein of unknown function (DUF541) - - - - - - - - - - - - SIMPL k59_396873_1 1005994.GTGU_01030 3.5e-05 43.9 COG1803@1|root,COG1803@2|Bacteria,1RD3D@1224|Proteobacteria,1S3XN@1236|Gammaproteobacteria 1236|Gammaproteobacteria G Methylglyoxal synthase mgsA GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0008150,GO:0008152,GO:0008929,GO:0009058,GO:0009438,GO:0009987,GO:0016829,GO:0016835,GO:0016838,GO:0019242,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046184,GO:0071704,GO:1901576 4.2.3.3 ko:K01734 ko00640,ko01120,map00640,map01120 - R01016 RC00424 ko00000,ko00001,ko01000 - - iECUMN_1333.ECUMN_1153,iYL1228.KPN_00992 MGS k59_396873_2 316407.4062531 4.85e-123 352.0 COG3110@1|root,COG3110@2|Bacteria,1RK33@1224|Proteobacteria,1RZRX@1236|Gammaproteobacteria,3XNYU@561|Escherichia 1236|Gammaproteobacteria S Uncharacterized protein conserved in bacteria (DUF2057) yccT - - ko:K09909 - - - - ko00000 - - - DUF2057 k59_679295_1 583355.Caka_1567 3.81e-65 211.0 COG1004@1|root,COG1004@2|Bacteria,46S6E@74201|Verrucomicrobia,3K7DX@414999|Opitutae 414999|Opitutae C Belongs to the UDP-glucose GDP-mannose dehydrogenase family - - 1.1.1.22 ko:K00012 ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100 M00014,M00129,M00361,M00362 R00286 RC00291 ko00000,ko00001,ko00002,ko01000 - - - UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N k59_170957_1 1229909.NSED_06535 1.93e-10 68.9 arCOG03042@1|root,arCOG03042@2157|Archaea 2157|Archaea KLT PFAM Tetratricopeptide repeat - - - - - - - - - - - - TPR_1,TPR_16,TPR_2,TPR_8 k59_1131318_1 1232437.KL662007_gene1684 2.42e-22 96.7 COG0517@1|root,COG0517@2|Bacteria,1MXI6@1224|Proteobacteria,42SSD@68525|delta/epsilon subdivisions,2WPWR@28221|Deltaproteobacteria,2MK6M@213118|Desulfobacterales 28221|Deltaproteobacteria S Putative transposase - - - - - - - - - - - - Y2_Tnp,Zn_Tnp_IS91 k59_1526775_1 194867.ALBQ01000032_gene992 8.39e-72 230.0 COG5434@1|root,COG5434@2|Bacteria,1MXP8@1224|Proteobacteria,2TVCM@28211|Alphaproteobacteria,2K2SP@204457|Sphingomonadales 204457|Sphingomonadales M Glycosyl hydrolases family 28 - - - - - - - - - - - - Glyco_hydro_28,Pectate_lyase_3 k59_792491_1 1121405.dsmv_1282 9.52e-58 202.0 COG3299@1|root,COG3299@2|Bacteria,1MWKI@1224|Proteobacteria,42QGQ@68525|delta/epsilon subdivisions,2WIVM@28221|Deltaproteobacteria,2MMI8@213118|Desulfobacterales 28221|Deltaproteobacteria S Baseplate J-like protein - - - - - - - - - - - - Baseplate_J k59_396906_1 190650.CC_3128 2.06e-14 79.3 COG0457@1|root,COG0457@2|Bacteria,1MVMG@1224|Proteobacteria,2TSGE@28211|Alphaproteobacteria,2KFVS@204458|Caulobacterales 204458|Caulobacterales S Sulfotransferase - - - - - - - - - - - - Sulfotransfer_3,TPR_14,TPR_16,TPR_19,TPR_8 k59_1526777_1 640512.BC1003_4195 3.65e-42 160.0 COG0542@1|root,COG0542@2|Bacteria,1MVBH@1224|Proteobacteria,2VHSN@28216|Betaproteobacteria,1K184@119060|Burkholderiaceae 28216|Betaproteobacteria O type VI secretion ATPase, ClpV1 family clpV - - ko:K11907 ko02025,ko03070,map02025,map03070 M00334 - - ko00000,ko00001,ko00002,ko02044 3.A.23.1 - - AAA,AAA_2,ClpB_D2-small,Clp_N k59_1696205_2 1469557.JSWF01000019_gene232 3.96e-52 177.0 COG2270@1|root,COG2270@2|Bacteria,4NEKI@976|Bacteroidetes,1HXEF@117743|Flavobacteriia 976|Bacteroidetes S Major facilitator superfamily - - - ko:K06902 ko04138,map04138 - - - ko00000,ko00001,ko02000,ko04131 2.A.1.24,9.A.15.1 - - ATG22 k59_1074601_1 582402.Hbal_3137 1.12e-57 197.0 COG1506@1|root,COG1506@2|Bacteria,1MUJ3@1224|Proteobacteria,2TUZZ@28211|Alphaproteobacteria,43W55@69657|Hyphomonadaceae 28211|Alphaproteobacteria E Peptidase S9 prolyl oligopeptidase active site - - - - - - - - - - - - Peptidase_S9 k59_1074601_2 1117647.M5M_00805 2.35e-05 45.8 COG3630@1|root,COG3630@2|Bacteria,1QJBU@1224|Proteobacteria,1THAJ@1236|Gammaproteobacteria,1JBFP@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C oxaloacetate decarboxylase gamma chain oadG - 4.1.1.3 ko:K01573 ko00620,ko01100,map00620,map01100 - R00217 RC00040 ko00000,ko00001,ko01000,ko02000 3.B.1.1.1 - - OAD_gamma k59_340468_1 498211.CJA_1981 1.18e-63 218.0 COG0553@1|root,COG0553@2|Bacteria,1MX6H@1224|Proteobacteria,1RNRZ@1236|Gammaproteobacteria,1FG63@10|Cellvibrio 1236|Gammaproteobacteria K Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair rapA GO:0000166,GO:0001000,GO:0003674,GO:0003676,GO:0003824,GO:0004386,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0019899,GO:0030554,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032553,GO:0032555,GO:0032559,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043175,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0045893,GO:0045935,GO:0046483,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0070063,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097367,GO:0097659,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141 - ko:K03580 - - - - ko00000,ko01000,ko03021 - - - Helicase_C,RapA_C,SNF2_N k59_58065_1 1123393.KB891316_gene1456 1.39e-31 119.0 28RZD@1|root,2ZEBA@2|Bacteria,1RBEH@1224|Proteobacteria,2VQVV@28216|Betaproteobacteria,1KS0X@119069|Hydrogenophilales 119069|Hydrogenophilales - - - - - - - - - - - - - - - k59_848864_1 504832.OCAR_5043 6.16e-111 350.0 COG5013@1|root,COG5013@2|Bacteria,1MW9S@1224|Proteobacteria,2TQJW@28211|Alphaproteobacteria,3JVHG@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria C Molybdopterin oxidoreductase Fe4S4 domain narZ - 1.7.5.1 ko:K00370 ko00910,ko01120,ko02020,map00910,map01120,map02020 M00529,M00530,M00804 R00798,R01106,R09497 RC02812 ko00000,ko00001,ko00002,ko01000 5.A.3.1 - - Molybdopterin,Molydop_binding,Nitr_red_alph_N k59_566477_1 384765.SIAM614_15647 1.29e-67 221.0 COG0747@1|root,COG0747@2|Bacteria,1MUPE@1224|Proteobacteria,2U0CD@28211|Alphaproteobacteria 28211|Alphaproteobacteria E COG0747 ABC-type dipeptide transport system, periplasmic component - - - ko:K02035 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - SBP_bac_5 k59_453225_1 396588.Tgr7_3178 5.11e-136 412.0 COG0469@1|root,COG0469@2|Bacteria,1NNNX@1224|Proteobacteria,1RYF5@1236|Gammaproteobacteria,1X04N@135613|Chromatiales 135613|Chromatiales G PFAM Pyruvate kinase barrel - - 2.7.1.40 ko:K00873 ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230 M00001,M00002,M00049,M00050 R00200,R00430,R01138,R01858,R02320 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - PK k59_792522_1 316407.85674724 3.55e-142 413.0 COG3051@1|root,COG3051@2|Bacteria,1MYI9@1224|Proteobacteria,1RQ32@1236|Gammaproteobacteria,3XNRW@561|Escherichia 1236|Gammaproteobacteria C Citrate (pro-3S)-lyase alpha chain citF GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.8.3.10 ko:K01643 ko02020,map02020 - R00362 RC00067,RC01118 ko00000,ko00001,ko01000 - - iEcSMS35_1347.EcSMS35_0634 CitF k59_58074_1 1415778.JQMM01000001_gene842 1.29e-59 196.0 COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,1RN9T@1236|Gammaproteobacteria,1J4WE@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O COG0265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain degS GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006508,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0009897,GO:0009986,GO:0009987,GO:0010033,GO:0016020,GO:0016021,GO:0016787,GO:0017171,GO:0019538,GO:0030288,GO:0030313,GO:0031224,GO:0031226,GO:0031233,GO:0031975,GO:0033554,GO:0035966,GO:0035967,GO:0042221,GO:0042597,GO:0042802,GO:0043170,GO:0044238,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051716,GO:0051788,GO:0070011,GO:0070887,GO:0071218,GO:0071310,GO:0071575,GO:0071704,GO:0071944,GO:0098552,GO:0140096,GO:1901564 - ko:K04691,ko:K04772 - - - - ko00000,ko01000,ko01002 - - - PDZ_2,Trypsin_2 k59_1187771_1 1071679.BG57_12965 8.05e-91 279.0 COG1408@1|root,COG1408@2|Bacteria,1MUH5@1224|Proteobacteria,2VH7E@28216|Betaproteobacteria,1JZT9@119060|Burkholderiaceae 28216|Betaproteobacteria S PFAM metallophosphoesterase - - - ko:K07098 - - - - ko00000 - - - Metallophos k59_1357359_1 702113.PP1Y_AT35834 4.03e-42 137.0 COG0291@1|root,COG0291@2|Bacteria,1N6V4@1224|Proteobacteria,2UF6K@28211|Alphaproteobacteria,2K5YR@204457|Sphingomonadales 204457|Sphingomonadales J Belongs to the bacterial ribosomal protein bL35 family rpmI - - ko:K02916 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L35p k59_1357359_2 1088721.NSU_1925 5.85e-68 207.0 COG0292@1|root,COG0292@2|Bacteria,1RGU2@1224|Proteobacteria,2U756@28211|Alphaproteobacteria,2K4FX@204457|Sphingomonadales 204457|Sphingomonadales J Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit rplT - - ko:K02887 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L20 k59_1301016_1 1121403.AUCV01000063_gene4178 2.18e-06 50.1 COG0845@1|root,COG0845@2|Bacteria,1MVAS@1224|Proteobacteria,42PKU@68525|delta/epsilon subdivisions,2WM5K@28221|Deltaproteobacteria,2MIM9@213118|Desulfobacterales 28221|Deltaproteobacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - ko:K07798,ko:K15727 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.6.1.4,8.A.1,8.A.1.2.1 - - DUF3347,HlyD_D23 k59_1301016_2 1307759.JOMJ01000003_gene2351 2.4e-93 305.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,43EBY@68525|delta/epsilon subdivisions,2X7W0@28221|Deltaproteobacteria,2MHDJ@213115|Desulfovibrionales 28221|Deltaproteobacteria V AcrB/AcrD/AcrF family - - - ko:K07787 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.6.1.4 - - ACR_tran k59_1301019_1 105559.Nwat_2897 1.97e-92 284.0 COG0305@1|root,COG0305@2|Bacteria,1MUG9@1224|Proteobacteria,1RPM2@1236|Gammaproteobacteria,1WW1X@135613|Chromatiales 135613|Chromatiales L it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins - - 3.6.4.12 ko:K02314 ko03030,ko04112,map03030,map04112 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB,DnaB_C,Intein_splicing,LAGLIDADG_3 k59_1244401_1 1454004.AW11_02016 1.65e-84 267.0 COG0296@1|root,COG0296@2|Bacteria,1MVM7@1224|Proteobacteria,2VJDX@28216|Betaproteobacteria 28216|Betaproteobacteria G trehalohydrolase treZ - 3.2.1.141 ko:K01236 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R09995,R11256 RC00049 ko00000,ko00001,ko00002,ko01000 - CBM48,GH13 - Alpha-amylase,CBM_48,DUF3459 k59_1470397_1 322710.Avin_23880 1.02e-28 113.0 COG0679@1|root,COG0679@2|Bacteria,1P2SH@1224|Proteobacteria,1RYK8@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Membrane transport protein - - - ko:K07088 - - - - ko00000 - - - Mem_trans k59_1301027_2 1122135.KB893134_gene3515 1.34e-58 193.0 COG3000@1|root,COG3000@2|Bacteria,1NR7X@1224|Proteobacteria,2TT68@28211|Alphaproteobacteria 28211|Alphaproteobacteria I COG3000 Sterol desaturase - - - - - - - - - - - - FA_hydroxylase k59_453258_1 246197.MXAN_0314 6.13e-63 223.0 COG0784@1|root,COG2202@1|root,COG4191@1|root,COG0784@2|Bacteria,COG2202@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria 1224|Proteobacteria T Histidine kinase - - - - - - - - - - - - HATPase_c,HisKA,PAS_4,Response_reg k59_453258_2 1149133.ppKF707_4129 3.33e-17 78.6 COG0784@1|root,COG0784@2|Bacteria,1QUN7@1224|Proteobacteria,1S4GM@1236|Gammaproteobacteria,1YKBA@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria T Response regulator receiver domain - - - ko:K02485 - - - - ko00000,ko02022 - - - Response_reg k59_1244409_1 1131553.JIBI01000017_gene565 4.29e-79 248.0 COG0743@1|root,COG0743@2|Bacteria,1MU4G@1224|Proteobacteria,2VHJY@28216|Betaproteobacteria,3723X@32003|Nitrosomonadales 28216|Betaproteobacteria I Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) dxr - 1.1.1.267 ko:K00099 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05688 RC01452 ko00000,ko00001,ko00002,ko01000 - - - DXPR_C,DXP_redisom_C,DXP_reductoisom k59_509871_1 1452718.JBOY01000094_gene2888 1.14e-20 87.0 COG4970@1|root,COG4970@2|Bacteria 2|Bacteria NU protein transport across the cell outer membrane - - - ko:K02246,ko:K10926 ko05111,map05111 M00429 - - ko00000,ko00001,ko00002,ko02044 - - - GspH,N_methyl k59_171065_1 936455.KI421499_gene4639 1.64e-28 120.0 COG0515@1|root,COG2203@1|root,COG3899@1|root,COG4191@1|root,COG0515@2|Bacteria,COG2203@2|Bacteria,COG3899@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2U320@28211|Alphaproteobacteria,3JWCJ@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria T Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - - - - - - - - - - AAA_16,GAF,HATPase_c,HisKA,PAS_9,Pkinase k59_453271_1 344747.PM8797T_05515 1.87e-52 179.0 COG1226@1|root,COG1226@2|Bacteria,2IYAZ@203682|Planctomycetes 203682|Planctomycetes P K transport systems - - - ko:K10716 - - - - ko00000,ko02000 1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6 - - Ion_trans_2,TrkA_C,TrkA_N k59_623626_1 1117647.M5M_01685 4.76e-95 299.0 COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,1RMZ8@1236|Gammaproteobacteria,1J59D@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria I Involved in the aerobic and anaerobic degradation of long-chain fatty acids via beta-oxidation cycle. Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA. It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate fadB - 1.1.1.35,4.2.1.17,5.1.2.3,5.3.3.8 ko:K01782,ko:K01825 ko00071,ko00280,ko00281,ko00310,ko00362,ko00380,ko00410,ko00640,ko00650,ko00903,ko00930,ko01040,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00362,map00380,map00410,map00640,map00650,map00903,map00930,map01040,map01100,map01110,map01120,map01130,map01200,map01212 M00032,M00087 R01975,R03026,R03045,R03276,R04137,R04170,R04203,R04204,R04224,R04737,R04738,R04739,R04740,R04741,R04744,R04745,R04746,R04748,R04749,R04756,R05066,R05305,R06411,R06412,R06941,R06942,R07935,R07951,R08093,R08094 RC00029,RC00099,RC00117,RC00241,RC00525,RC00831,RC00834,RC00896,RC01078,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 - - - 3HCDH,3HCDH_N,ECH_1 k59_171907_1 56110.Oscil6304_3012 1.29e-20 89.0 COG0546@1|root,COG0546@2|Bacteria,1G52P@1117|Cyanobacteria,1HB0I@1150|Oscillatoriales 1117|Cyanobacteria S PFAM Haloacid dehalogenase-like hydrolase cbbZp - 3.1.3.18 ko:K01091 ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130 - R01334 RC00017 ko00000,ko00001,ko01000 - - - HAD_2 k59_171907_2 436308.Nmar_0298 5.99e-56 176.0 arCOG03272@1|root,arCOG03272@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_1309937_1 194867.ALBQ01000019_gene3692 1.95e-34 135.0 COG0784@1|root,COG4251@1|root,COG0784@2|Bacteria,COG4251@2|Bacteria,1NC9X@1224|Proteobacteria,2TT77@28211|Alphaproteobacteria,2JZXT@204457|Sphingomonadales 204457|Sphingomonadales T light-regulated signal transduction histidine kinase - - - - - - - - - - - - GAF,HWE_HK,PAS_2,PHY,Response_reg k59_462283_1 754331.AEME01000001_gene2485 3.66e-95 289.0 COG0192@1|root,COG0192@2|Bacteria,1MUFQ@1224|Proteobacteria,1RNV6@1236|Gammaproteobacteria,3XP3M@561|Escherichia 1236|Gammaproteobacteria H Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme metK GO:0000096,GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004478,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006534,GO:0006555,GO:0006556,GO:0006575,GO:0006725,GO:0006732,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009066,GO:0009069,GO:0009108,GO:0009116,GO:0009119,GO:0009987,GO:0016740,GO:0016765,GO:0017076,GO:0017144,GO:0019752,GO:0030554,GO:0030955,GO:0031420,GO:0032553,GO:0032555,GO:0032559,GO:0033353,GO:0034641,GO:0035639,GO:0036094,GO:0042278,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046128,GO:0046439,GO:0046483,GO:0046498,GO:0046500,GO:0046872,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0097159,GO:0097367,GO:1901135,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901576,GO:1901605,GO:1901657 2.5.1.6 ko:K00789 ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230 M00034,M00035,M00368,M00609 R00177,R04771 RC00021,RC01211 ko00000,ko00001,ko00002,ko01000 - - iJN746.PP_4967,iYL1228.KPN_03375 S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N k59_462290_1 452652.KSE_12560 8.35e-79 246.0 COG3049@1|root,COG3049@2|Bacteria,2GK9Z@201174|Actinobacteria 201174|Actinobacteria M Choloylglycine hydrolase - - 3.5.1.24 ko:K01442 ko00120,ko00121,ko01100,map00120,map00121,map01100 - R02797,R03975,R03977,R04486,R04487,R05835 RC00090,RC00096 ko00000,ko00001,ko01000 - - - CBAH k59_1648665_1 1232410.KI421427_gene1264 5.12e-47 167.0 COG0477@1|root,COG2814@2|Bacteria,1MV79@1224|Proteobacteria,42R72@68525|delta/epsilon subdivisions,2WMSM@28221|Deltaproteobacteria 28221|Deltaproteobacteria EGP Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 k59_744647_1 316407.85676784 9.39e-90 269.0 COG3833@1|root,COG3833@2|Bacteria,1QA3Z@1224|Proteobacteria,1RQ00@1236|Gammaproteobacteria,3XNEJ@561|Escherichia 1236|Gammaproteobacteria P probably responsible for the translocation of the substrate across the membrane malG GO:0003674,GO:0003824,GO:0005215,GO:0005363,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0008643,GO:0015144,GO:0015154,GO:0015157,GO:0015399,GO:0015405,GO:0015422,GO:0015423,GO:0015766,GO:0015768,GO:0015772,GO:0015774,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022857,GO:0031224,GO:0031226,GO:0032991,GO:0033036,GO:0033037,GO:0034219,GO:0042623,GO:0042626,GO:0042956,GO:0043190,GO:0043211,GO:0043492,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0098533,GO:0098796,GO:0098797,GO:1902494,GO:1902495,GO:1904949,GO:1990060,GO:1990351 - ko:K10110 ko02010,map02010 M00194 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.1,3.A.1.1.22 - iSSON_1240.SSON_4210,iYL1228.KPN_04421 BPD_transp_1 k59_1366402_2 436308.Nmar_0380 5.79e-37 135.0 arCOG10517@1|root,arCOG10517@2157|Archaea,41T0I@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1535682_1 1454004.AW11_00031 1.98e-53 188.0 2A8Z1@1|root,30Y2U@2|Bacteria,1PJYG@1224|Proteobacteria,2VJ83@28216|Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_914144_1 419610.Mext_1541 6.57e-32 117.0 COG2096@1|root,COG2096@2|Bacteria,1RDUF@1224|Proteobacteria,2U5J1@28211|Alphaproteobacteria,1JTVM@119045|Methylobacteriaceae 28211|Alphaproteobacteria S PFAM Cobalamin adenosyltransferase MA20_20540 - 2.5.1.17 ko:K00798 ko00860,ko01100,map00860,map01100 M00122 R01492,R05220,R07268 RC00533 ko00000,ko00001,ko00002,ko01000 - - - Cob_adeno_trans k59_1648689_1 641526.ADIWIN_0824 3.04e-56 177.0 2CG1Y@1|root,31NHZ@2|Bacteria,4NQ9Z@976|Bacteroidetes,1I375@117743|Flavobacteriia 976|Bacteroidetes S Protein of unknown function (DUF1573) - - - - - - - - - - - - DUF1573 k59_914152_1 436308.Nmar_1316 8.04e-34 125.0 COG0477@1|root,arCOG00130@2157|Archaea,41T0X@651137|Thaumarchaeota 651137|Thaumarchaeota G major facilitator superfamily - - - ko:K08153,ko:K08221 - M00717 - - ko00000,ko00002,ko02000 2.A.1.2.8,2.A.1.32 - - MFS_1 k59_914152_2 436308.Nmar_1318 1.75e-35 124.0 COG1826@1|root,arCOG02694@2157|Archaea,41SRR@651137|Thaumarchaeota 651137|Thaumarchaeota U mttA/Hcf106 family - - - ko:K03116 ko03060,ko03070,map03060,map03070 M00336 - - ko00000,ko00001,ko00002,ko02044 2.A.64 - - MttA_Hcf106 k59_349805_1 1123037.AUDE01000017_gene2469 4.29e-41 157.0 COG3291@1|root,COG3291@2|Bacteria,4NDZQ@976|Bacteroidetes,1HX5A@117743|Flavobacteriia 976|Bacteroidetes M C-terminal domain of CHU protein family - - - - - - - - - - - - CHU_C,Cleaved_Adhesin,MAM,fn3 k59_1535687_1 436308.Nmar_0265 5.7e-121 360.0 COG0373@1|root,arCOG01036@2157|Archaea,41SDM@651137|Thaumarchaeota 651137|Thaumarchaeota H Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) - - 1.2.1.70 ko:K02492 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R04109 RC00055,RC00149 ko00000,ko00001,ko00002,ko01000 - - - GlutR_N,Shikimate_DH k59_1028056_1 1430440.MGMSRv2_3743 1.77e-46 166.0 COG0124@1|root,COG0124@2|Bacteria,1MV2K@1224|Proteobacteria,2TSTH@28211|Alphaproteobacteria,2JQ38@204441|Rhodospirillales 204441|Rhodospirillales J histidyl-tRNA synthetase hisS - 6.1.1.21 ko:K01892 ko00970,map00970 M00359,M00360 R03655 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,tRNA-synt_His k59_1705008_1 742766.HMPREF9455_01678 2.3e-17 85.9 COG2382@1|root,COG2382@2|Bacteria,4NF50@976|Bacteroidetes,2FNWF@200643|Bacteroidia,22Z5C@171551|Porphyromonadaceae 976|Bacteroidetes P Putative esterase - - - - - - - - - - - - Esterase,Glyco_hydro_10 k59_518488_1 1088721.NSU_1815 1.68e-78 239.0 COG4704@1|root,COG4704@2|Bacteria,1REQD@1224|Proteobacteria,2U8UI@28211|Alphaproteobacteria,2K510@204457|Sphingomonadales 204457|Sphingomonadales S protein conserved in bacteria - - - - - - - - - - - - DUF2141 k59_970211_1 768671.ThimaDRAFT_1207 1.34e-63 211.0 COG2918@1|root,COG2918@2|Bacteria,1MW9B@1224|Proteobacteria,1RPNQ@1236|Gammaproteobacteria,1WWFZ@135613|Chromatiales 135613|Chromatiales H Belongs to the glutamate--cysteine ligase type 1 family. Type 1 subfamily gshA - 6.3.2.2 ko:K01919 ko00270,ko00480,ko01100,map00270,map00480,map01100 M00118 R00894,R10993 RC00064,RC00090 ko00000,ko00001,ko00002,ko01000 - - - Glu_cys_ligase k59_349826_1 1469245.JFBG01000007_gene703 1.02e-108 326.0 COG0201@1|root,COG0201@2|Bacteria,1MVU7@1224|Proteobacteria,1RNJV@1236|Gammaproteobacteria,1WWJA@135613|Chromatiales 135613|Chromatiales U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently secY - - ko:K03076 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5 - - SecY k59_1309948_1 1449351.RISW2_23825 1.07e-31 126.0 COG1975@1|root,COG1975@2|Bacteria,1MXKU@1224|Proteobacteria,2TUF3@28211|Alphaproteobacteria,4KM1D@93682|Roseivivax 28211|Alphaproteobacteria O XdhC CoxI family protein MA20_09415 - - ko:K07402 - - - - ko00000 - - - XdhC_C,XdhC_CoxI k59_1309948_2 266117.Rxyl_0116 5.34e-29 107.0 COG1975@1|root,COG1975@2|Bacteria,2IJ4H@201174|Actinobacteria,4CTVX@84995|Rubrobacteria 84995|Rubrobacteria O XdhC and CoxI family - - - - - - - - - - - - XdhC_CoxI k59_914163_1 392499.Swit_4607 9.07e-91 277.0 COG0183@1|root,COG0183@2|Bacteria,1MUZV@1224|Proteobacteria,2TRHF@28211|Alphaproteobacteria,2K20B@204457|Sphingomonadales 204457|Sphingomonadales I acetyl-coa acetyltransferase - - - - - - - - - - - - - k59_970213_1 6087.XP_002166181.2 1.59e-32 127.0 COG1785@1|root,KOG4126@2759|Eukaryota,38GD6@33154|Opisthokonta,3B9Y3@33208|Metazoa 33208|Metazoa P alkaline phosphatase activity ALPL GO:0000003,GO:0000287,GO:0001501,GO:0001503,GO:0001958,GO:0002020,GO:0002237,GO:0003006,GO:0003674,GO:0003824,GO:0004035,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005615,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0005903,GO:0006629,GO:0006644,GO:0006650,GO:0006654,GO:0006793,GO:0006796,GO:0007275,GO:0007399,GO:0007584,GO:0007586,GO:0008150,GO:0008152,GO:0008270,GO:0008610,GO:0008654,GO:0009058,GO:0009605,GO:0009607,GO:0009617,GO:0009653,GO:0009719,GO:0009725,GO:0009790,GO:0009792,GO:0009887,GO:0009888,GO:0009897,GO:0009986,GO:0009987,GO:0009991,GO:0010033,GO:0014070,GO:0016020,GO:0016311,GO:0016462,GO:0016787,GO:0016788,GO:0016791,GO:0016817,GO:0016818,GO:0019637,GO:0019899,GO:0021915,GO:0022008,GO:0022414,GO:0030016,GO:0030154,GO:0031012,GO:0031214,GO:0031224,GO:0031225,GO:0031226,GO:0031667,GO:0031960,GO:0032496,GO:0032501,GO:0032502,GO:0033273,GO:0033280,GO:0033993,GO:0034505,GO:0035264,GO:0035295,GO:0036075,GO:0036342,GO:0040007,GO:0042221,GO:0042476,GO:0042578,GO:0042802,GO:0042803,GO:0043009,GO:0043167,GO:0043169,GO:0043207,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043230,GO:0043232,GO:0043292,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044421,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045017,GO:0046473,GO:0046474,GO:0046486,GO:0046658,GO:0046677,GO:0046872,GO:0046914,GO:0046983,GO:0048513,GO:0048545,GO:0048589,GO:0048705,GO:0048731,GO:0048856,GO:0048869,GO:0050896,GO:0051384,GO:0051704,GO:0051707,GO:0051716,GO:0060348,GO:0060349,GO:0060350,GO:0060429,GO:0065010,GO:0070887,GO:0071310,GO:0071407,GO:0071529,GO:0071704,GO:0071944,GO:0090407,GO:0098552,GO:0098862,GO:0099080,GO:0099081,GO:0099512,GO:1901576,GO:1901700 3.1.3.1 ko:K01077,ko:K21411 ko00730,ko00790,ko01100,ko02020,map00730,map00790,map01100,map02020 M00126 R02135,R04620 RC00017 ko00000,ko00001,ko00002,ko00537,ko01000,ko03400,ko04147 - - - Alk_phosphatase k59_970213_2 1122137.AQXF01000006_gene719 5.75e-34 124.0 COG0810@1|root,COG0810@2|Bacteria 2|Bacteria M energy transducer activity - - 2.4.1.18 ko:K00700,ko:K03832 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R02110 - ko00000,ko00001,ko00002,ko01000,ko02000,ko04147 2.C.1.1 CBM48,GH13 - Peptidase_M56,TonB_C k59_1140097_1 1042377.AFPJ01000036_gene1233 1.42e-55 191.0 COG3119@1|root,COG3119@2|Bacteria,1MUJH@1224|Proteobacteria,1RN2V@1236|Gammaproteobacteria 1236|Gammaproteobacteria P COG3119 Arylsulfatase A and related enzymes - - 3.1.6.1 ko:K01130 ko00140,ko00600,map00140,map00600 - R03980,R04856 RC00128,RC00231 ko00000,ko00001,ko01000 - - - Sulfatase,Sulfatase_C k59_744682_2 243277.VC_1596 4.46e-52 175.0 COG1085@1|root,COG1085@2|Bacteria,1MU3E@1224|Proteobacteria,1RMDK@1236|Gammaproteobacteria,1XTKC@135623|Vibrionales 135623|Vibrionales H Galactose-1-phosphate uridylyltransferase galT - 2.7.7.12 ko:K00965 ko00052,ko00520,ko01100,ko04917,map00052,map00520,map01100,map04917 M00362,M00554,M00632 R00955 RC00002 ko00000,ko00001,ko00002,ko01000 - - - GalP_UDP_tr_C,GalP_UDP_transf k59_1648725_1 1234364.AMSF01000070_gene2156 2.47e-24 95.5 COG3094@1|root,COG3094@2|Bacteria,1QB3J@1224|Proteobacteria,1T6ME@1236|Gammaproteobacteria,1X7S1@135614|Xanthomonadales 135614|Xanthomonadales S Invasion gene expression up-regulator, SirB - - - - - - - - - - - - SirB k59_1648725_2 1088721.NSU_4542 8.25e-64 214.0 COG3256@1|root,COG3256@2|Bacteria,1MVT1@1224|Proteobacteria,2TUJ1@28211|Alphaproteobacteria,2K2ZX@204457|Sphingomonadales 204457|Sphingomonadales P Nitric oxide reductase - - 1.7.2.5 ko:K04561 ko00910,ko01120,map00910,map01120 M00529 R00294 RC02794 ko00000,ko00001,ko00002,ko01000 3.D.4.10 - - COX1 k59_575117_2 765911.Thivi_4387 4.03e-14 74.7 COG2932@1|root,COG2932@2|Bacteria,1RBQ6@1224|Proteobacteria,1S2AF@1236|Gammaproteobacteria,1WZT7@135613|Chromatiales 135613|Chromatiales K Peptidase S24-like - - - - - - - - - - - - HTH_3,Peptidase_S24 k59_575117_3 598467.BrE312_3298 1.48e-13 68.2 COG3423@1|root,COG3423@2|Bacteria,1N8W7@1224|Proteobacteria,1S9J5@1236|Gammaproteobacteria 1236|Gammaproteobacteria K Winged helix-turn-helix DNA-binding - - - ko:K07724 - - - - ko00000,ko03000 - - - HTH_35 k59_575117_5 1304885.AUEY01000018_gene1088 5.46e-118 379.0 COG2801@1|root,COG3415@1|root,COG2801@2|Bacteria,COG3415@2|Bacteria,1MVXV@1224|Proteobacteria,42PU3@68525|delta/epsilon subdivisions,2WJ15@28221|Deltaproteobacteria 28221|Deltaproteobacteria L Mu transposase, C-terminal - - - ko:K07497 - - - - ko00000 - - - HTH_Tnp_Mu_1,Mu-transpos_C,rve k59_575117_8 1121033.AUCF01000017_gene3801 1.67e-66 213.0 COG2842@1|root,COG2842@2|Bacteria,1R5D4@1224|Proteobacteria,2U6S1@28211|Alphaproteobacteria,2JTRY@204441|Rhodospirillales 204441|Rhodospirillales S AAA domain - - - - - - - - - - - - AAA_22 k59_575117_9 748280.NH8B_1646 2.25e-39 141.0 COG0640@1|root,COG0640@2|Bacteria,1MZB0@1224|Proteobacteria,2VWWY@28216|Betaproteobacteria,2KS9P@206351|Neisseriales 206351|Neisseriales K Transcriptional regulator - - - - - - - - - - - - - k59_575117_10 1123257.AUFV01000013_gene2806 4.66e-29 109.0 2E453@1|root,32Z15@2|Bacteria,1N94C@1224|Proteobacteria,1SERM@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - LacI k59_575117_13 443143.GM18_3352 4.93e-26 105.0 2CBK1@1|root,32RTI@2|Bacteria,1N1PI@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - Phage_Mu_Gam k59_575117_18 1122925.KB895376_gene415 5.75e-18 82.0 2DP5S@1|root,330N4@2|Bacteria,1VH2J@1239|Firmicutes,4ICZW@91061|Bacilli,27306@186822|Paenibacillaceae 91061|Bacilli - - - - - - - - - - - - - - - k59_575117_19 1042375.AFPL01000042_gene3810 3.19e-05 50.1 COG4382@1|root,COG4382@2|Bacteria,1N8KH@1224|Proteobacteria,1S3C4@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Mu-like prophage protein gp16 - - - - - - - - - - - - DUF1018 k59_575117_21 278957.ABEA03000173_gene2448 5.54e-44 147.0 2DPAY@1|root,331AT@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - ASCH k59_575117_22 637911.AM305_00930 1.28e-28 109.0 COG5566@1|root,COG5566@2|Bacteria,1N0IH@1224|Proteobacteria,1SBYY@1236|Gammaproteobacteria,1YARY@135625|Pasteurellales 135625|Pasteurellales S Mor transcription activator family - - - - - - - - - - - - Mor k59_575117_28 1129374.AJE_15859 1.71e-42 147.0 2ACTC@1|root,312E7@2|Bacteria,1R49I@1224|Proteobacteria,1S83K@1236|Gammaproteobacteria,46BR0@72275|Alteromonadaceae 1236|Gammaproteobacteria S Protein of unknown function (DUF3486) - - - - - - - - - - - - DUF3486 k59_575117_29 1415754.JQMK01000002_gene3208 4.46e-216 614.0 COG4373@1|root,COG4373@2|Bacteria,1N2KG@1224|Proteobacteria,1RNKU@1236|Gammaproteobacteria,465WU@72275|Alteromonadaceae 1236|Gammaproteobacteria S COG4373 Mu-like prophage FluMu protein gp28 - - - - - - - - - - - - Terminase_6 k59_575117_30 28229.ND2E_1002 1.38e-153 456.0 COG4383@1|root,COG4383@2|Bacteria,1MWNS@1224|Proteobacteria,1RNBP@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Mu-like prophage protein gp29 - - - - - - - - - - - - DUF935 k59_575117_31 1244869.H261_11839 9.06e-113 343.0 COG2369@1|root,COG2369@2|Bacteria,1R40R@1224|Proteobacteria,2U3XS@28211|Alphaproteobacteria,2JRJF@204441|Rhodospirillales 204441|Rhodospirillales S protein, homolog of phage Mu protein gp30 - - - - - - - - - - - - Phage_Mu_F k59_575117_32 1122244.AUGF01000001_gene1723 1.32e-10 64.3 COG5005@1|root,COG5005@2|Bacteria,1N6UC@1224|Proteobacteria,1SCCU@1236|Gammaproteobacteria 1236|Gammaproteobacteria S TIGRFAM phage virion morphogenesis - - - - - - - - - - - - Phage_tail_S k59_575117_34 396588.Tgr7_1638 1.27e-87 275.0 COG4388@1|root,COG4388@2|Bacteria,1RA2J@1224|Proteobacteria,1RZEI@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Mu-like prophage I protein - - - - - - - - - - - - Mu-like_Pro k59_575117_35 999549.KI421513_gene3102 4.73e-26 102.0 2CDSP@1|root,32RYD@2|Bacteria,1N213@1224|Proteobacteria,2UFIC@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_575117_36 497321.C664_01280 6.56e-127 372.0 COG4397@1|root,COG4397@2|Bacteria,1MWX8@1224|Proteobacteria,2VJQE@28216|Betaproteobacteria,2KY00@206389|Rhodocyclales 206389|Rhodocyclales S Mu-like prophage major head subunit gpT - - - - - - - - - - - - Mu-like_gpT k59_350775_1 1129794.C427_1366 1.19e-45 172.0 COG0596@1|root,COG4206@1|root,COG0596@2|Bacteria,COG4206@2|Bacteria,1QVV2@1224|Proteobacteria,1T4JF@1236|Gammaproteobacteria 1236|Gammaproteobacteria H TonB dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_11749_2 1122137.AQXF01000002_gene459 1.04e-59 192.0 COG0031@1|root,COG0031@2|Bacteria,1MUBE@1224|Proteobacteria,2TR4W@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Cysteine synthase cysB GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004124,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0019344,GO:0019752,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.5.1.47 ko:K01738 ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230 M00021 R00897,R03601,R04859 RC00020,RC02814,RC02821 ko00000,ko00001,ko00002,ko01000 - - - PALP k59_350780_1 436308.Nmar_0681 1.31e-29 119.0 COG0457@1|root,arCOG03032@2157|Archaea,41SBD@651137|Thaumarchaeota 651137|Thaumarchaeota S TPR repeat - - - - - - - - - - - - TPR_1,TPR_2,TPR_8 k59_1480947_1 754476.Q7A_2346 1.24e-64 214.0 COG0661@1|root,COG0661@2|Bacteria,1MU1Z@1224|Proteobacteria,1RNQM@1236|Gammaproteobacteria,45ZT8@72273|Thiotrichales 72273|Thiotrichales S Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis ubiB - - ko:K03688 - - - - ko00000 - - - ABC1 k59_1367583_1 1121935.AQXX01000109_gene482 1.33e-95 300.0 COG0845@1|root,COG5569@1|root,COG0845@2|Bacteria,COG5569@2|Bacteria,1MVAS@1224|Proteobacteria,1RPBZ@1236|Gammaproteobacteria,1XIE5@135619|Oceanospirillales 135619|Oceanospirillales M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - ko:K07798 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.6.1.4,8.A.1 - - CusF_Ec,HlyD_D23 k59_1029202_1 436308.Nmar_1499 1.06e-87 264.0 COG0338@1|root,arCOG03416@2157|Archaea,41SHH@651137|Thaumarchaeota 651137|Thaumarchaeota L PFAM D12 class N6 adenine-specific DNA methyltransferase - - 2.1.1.72 ko:K06223 ko03430,map03430 - - - ko00000,ko00001,ko01000,ko02048,ko03032,ko03400 - - - MethyltransfD12 k59_124661_1 876044.IMCC3088_2290 1.15e-79 265.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1J8T8@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_1091227_1 247633.GP2143_09040 9.32e-46 166.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1J8T8@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_1091227_2 768671.ThimaDRAFT_0212 0.000197 47.8 COG0845@1|root,COG0845@2|Bacteria,1MU78@1224|Proteobacteria,1RPI1@1236|Gammaproteobacteria,1WVVM@135613|Chromatiales 135613|Chromatiales M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - ko:K03585 ko01501,ko01503,map01501,map01503 M00646,M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000,ko03036 2.A.6.2,8.A.1.6 - - HlyD_D23 k59_866267_1 1229909.NSED_09615 1.31e-100 296.0 COG1646@1|root,arCOG01085@2157|Archaea,41SH4@651137|Thaumarchaeota 651137|Thaumarchaeota H Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids - - 2.5.1.41 ko:K17104 ko00564,map00564 - R04158 RC01091 ko00000,ko00001,ko01000 - - - PcrB k59_582683_2 1229909.NSED_02590 7.9e-06 44.7 COG1872@1|root,arCOG04058@2157|Archaea,41TAX@651137|Thaumarchaeota 651137|Thaumarchaeota S DUF167 - - - ko:K09131 - - - - ko00000 - - - DUF167 k59_1712687_1 658612.MD26_02895 2.69e-26 112.0 COG1570@1|root,COG1570@2|Bacteria,1MUA4@1224|Proteobacteria,1RNAZ@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides xseA GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006308,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008855,GO:0009056,GO:0009057,GO:0009318,GO:0009987,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0019439,GO:0032991,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901361,GO:1901575,GO:1902494 3.1.11.6 ko:K03601 ko03430,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - Exonuc_VII_L,tRNA_anti_2 k59_1769276_1 189753.AXAS01000055_gene5725 8.6e-12 71.2 COG0515@1|root,COG2203@1|root,COG3899@1|root,COG4191@1|root,COG0515@2|Bacteria,COG2203@2|Bacteria,COG3899@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2U320@28211|Alphaproteobacteria,3JWCJ@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria T Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - - - - - - - - - - AAA_16,GAF,HATPase_c,HisKA,PAS_9,Pkinase k59_582688_1 983920.Y88_2272 1.84e-52 172.0 COG0756@1|root,COG0756@2|Bacteria,1RA7P@1224|Proteobacteria,2U7B5@28211|Alphaproteobacteria,2K4E7@204457|Sphingomonadales 204457|Sphingomonadales F This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA dut - 3.6.1.23 ko:K01520 ko00240,ko00983,ko01100,map00240,map00983,map01100 M00053 R02100,R11896 RC00002 ko00000,ko00001,ko00002,ko01000,ko03400 - - - dUTPase k59_469818_1 558884.JRGM01000040_gene1270 9.2e-74 229.0 COG0846@1|root,COG0846@2|Bacteria,1MUK1@1224|Proteobacteria,1RMX5@1236|Gammaproteobacteria,1Y4BE@135624|Aeromonadales 135624|Aeromonadales K NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form cobB - - ko:K12410 - - - - ko00000,ko01000 - - - SIR2 k59_1147605_1 1173028.ANKO01000028_gene3247 2.6e-50 189.0 COG0689@1|root,COG0823@1|root,COG2374@1|root,COG2931@1|root,COG3210@1|root,COG0689@2|Bacteria,COG0823@2|Bacteria,COG2374@2|Bacteria,COG2931@2|Bacteria,COG3210@2|Bacteria,1G0DX@1117|Cyanobacteria,1H9Z9@1150|Oscillatoriales 1117|Cyanobacteria QU COG2931 RTX toxins and related Ca2 -binding proteins - - - - - - - - - - - - DUF4347,FG-GAP,He_PIG,HemolysinCabind,VCBS k59_1317883_1 1459636.NTE_03247 5.44e-52 179.0 COG3608@1|root,arCOG02889@2157|Archaea 2157|Archaea S Succinylglutamate desuccinylase aspartoacylase - - - ko:K06987 - - - - ko00000 - - - AstE_AspA,Peptidase_M14 k59_921884_1 477228.YO5_16920 1.21e-92 281.0 COG0859@1|root,COG0859@2|Bacteria,1MYZA@1224|Proteobacteria,1RPMN@1236|Gammaproteobacteria,1Z16E@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria M COG0859 ADP-heptose LPS heptosyltransferase rfaC GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0008713,GO:0008920,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016740,GO:0016757,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0046401,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 - ko:K02841 ko00540,ko01100,map00540,map01100 M00080 - - ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT9 iB21_1397.B21_03429,iECBD_1354.ECBD_0105,iECB_1328.ECB_03478,iECD_1391.ECD_03478,iECNA114_1301.ECNA114_3774,iECSF_1327.ECSF_3456,iSF_1195.SF3661,iS_1188.S4107 Glyco_transf_9 k59_921884_2 1056512.D515_01627 2.46e-08 54.7 COG0859@1|root,COG0859@2|Bacteria,1MXA2@1224|Proteobacteria,1RMBF@1236|Gammaproteobacteria,1XTBX@135623|Vibrionales 135623|Vibrionales M ADP-heptose--LPS heptosyltransferase II rfaF - - ko:K02843 ko00540,ko01100,map00540,map01100 M00080 - - ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT9 - Glyco_transf_9 k59_695781_1 936455.KI421499_gene3633 1.85e-41 157.0 COG0642@1|root,COG2205@2|Bacteria,1N1Z2@1224|Proteobacteria,2TVIP@28211|Alphaproteobacteria,3JVVU@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria T HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - - - - - - - - - - - 2CSK_N,HATPase_c,HisKA k59_582707_1 1229909.NSED_00170 4.71e-121 357.0 COG0677@1|root,arCOG00252@2157|Archaea,41S8F@651137|Thaumarchaeota 651137|Thaumarchaeota M Belongs to the UDP-glucose GDP-mannose dehydrogenase family - - - - - - - - - - - - - k59_18260_1 399795.CtesDRAFT_PD2086 2.05e-10 67.0 COG0457@1|root,COG0457@2|Bacteria,1Q84V@1224|Proteobacteria,2VJAQ@28216|Betaproteobacteria,4AB2J@80864|Comamonadaceae 28216|Betaproteobacteria NU PFAM TPR repeat-containing protein - - - - - - - - - - - - DUF4440,TPR_11,TPR_16,TPR_17,TPR_19,TPR_8 k59_639513_1 316407.85675950 6.79e-92 269.0 COG3787@1|root,COG3787@2|Bacteria,1RH76@1224|Proteobacteria,1S6F1@1236|Gammaproteobacteria,3XPN7@561|Escherichia 1236|Gammaproteobacteria S cofactor binding yhbP GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - ko:K09979 - - - - ko00000 - - - Putative_PNPOx k59_752310_1 258594.RPA4691 1.02e-30 124.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,2TQR7@28211|Alphaproteobacteria,3JSI9@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria NT chemotaxis - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - HAMP,MCPsignal k59_243808_1 1288494.EBAPG3_28620 8.26e-18 80.1 COG3216@1|root,COG3216@2|Bacteria,1RGV6@1224|Proteobacteria,2VSHR@28216|Betaproteobacteria,3732Y@32003|Nitrosomonadales 28216|Betaproteobacteria S Uncharacterized protein conserved in bacteria (DUF2062) - - - ko:K09928 - - - - ko00000 - - - DUF2062 k59_243808_2 522306.CAP2UW1_2097 7.17e-49 163.0 COG0122@1|root,COG0122@2|Bacteria,1MX9C@1224|Proteobacteria,2VHMQ@28216|Betaproteobacteria,1KPY7@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria L DNA replication, recombination and repair alkA - 3.2.2.21 ko:K01247 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - HhH-GPD k59_866335_1 247634.GPB2148_1148 2.69e-136 413.0 COG3383@1|root,COG3383@2|Bacteria,1QTZB@1224|Proteobacteria,1T1JA@1236|Gammaproteobacteria,1J9HS@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C NADH-ubiquinone oxidoreductase-G iron-sulfur binding region fdhF GO:0003674,GO:0003824,GO:0003954,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0008150,GO:0008152,GO:0009987,GO:0015942,GO:0015944,GO:0016491,GO:0016651,GO:0016999,GO:0017144,GO:0019752,GO:0030151,GO:0032787,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0071704 1.17.1.9,1.17.99.7 ko:K00123,ko:K22015 ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200 - R00519 RC02796 ko00000,ko00001,ko01000 - - iECBD_1354.ECBD_3953 Fer2_4,Fer4,Fer4_7,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3 k59_1599806_1 391626.OAN307_c18840 2.58e-98 296.0 COG2826@1|root,COG2826@2|Bacteria,1PP49@1224|Proteobacteria,2TRVA@28211|Alphaproteobacteria 28211|Alphaproteobacteria L COG2826 Transposase and inactivated derivatives, IS30 family - - - - - - - - - - - - HTH_38,rve k59_809402_2 1121937.AUHJ01000017_gene3028 3.3e-23 94.7 COG3871@1|root,COG3871@2|Bacteria 2|Bacteria S Pyridoxamine 5'-phosphate oxidase - - - ko:K07006 - - - - ko00000 - - - Putative_PNPOx k59_188079_2 1280944.HY17_15965 0.0 891.0 COG2072@1|root,COG2072@2|Bacteria,1MU71@1224|Proteobacteria,2TV2E@28211|Alphaproteobacteria,43ZBN@69657|Hyphomonadaceae 28211|Alphaproteobacteria P flavoprotein involved in K transport MA20_23085 - - - - - - - - - - - FMO-like,K_oxygenase,NAD_binding_8,Pyr_redox_2 k59_1543746_1 247634.GPB2148_61 5.62e-40 139.0 COG1028@1|root,COG1028@2|Bacteria,1N8G3@1224|Proteobacteria,1RZ80@1236|Gammaproteobacteria,1J6NN@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria IQ NAD dependent epimerase/dehydratase family - - - - - - - - - - - - adh_short,adh_short_C2 k59_1430097_1 1382356.JQMP01000003_gene2503 1.85e-71 230.0 COG0195@1|root,COG0195@2|Bacteria,2G5M5@200795|Chloroflexi,27XPJ@189775|Thermomicrobia 189775|Thermomicrobia K Participates in both transcription termination and antitermination nusA - - ko:K02600 - - - - ko00000,ko03009,ko03021 - - - KH_5,NusA_N,S1 k59_18304_1 90814.KL370892_gene2304 1.36e-05 53.9 COG5002@1|root,COG5002@2|Bacteria,1QVXJ@1224|Proteobacteria,1T2NA@1236|Gammaproteobacteria 1236|Gammaproteobacteria T Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) - - - - - - - - - - - - HATPase_c,HisKA,PAS_4,Response_reg k59_809407_1 436308.Nmar_0554 4.4e-106 315.0 COG1060@1|root,arCOG00656@2157|Archaea,41SCN@651137|Thaumarchaeota 651137|Thaumarchaeota C Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2) mqnC - - - - - - - - - - - Radical_SAM k59_1147637_1 935261.JAGL01000013_gene3541 2.63e-09 62.0 COG0559@1|root,COG0559@2|Bacteria,1MVND@1224|Proteobacteria,2TRMA@28211|Alphaproteobacteria,43GRU@69277|Phyllobacteriaceae 28211|Alphaproteobacteria E Belongs to the binding-protein-dependent transport system permease family urtB - - ko:K11960 ko02010,map02010 M00323 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4.4,3.A.1.4.5 - - BPD_transp_2 k59_131197_1 1187851.A33M_3265 4e-47 158.0 COG3415@1|root,COG3415@2|Bacteria,1RDMQ@1224|Proteobacteria,2U7PU@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Winged helix-turn helix - - - - - - - - - - - - HTH_29,HTH_32,HTH_33 k59_752354_2 436308.Nmar_1528 2.57e-14 74.3 arCOG07561@1|root,arCOG07561@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - TSP_3,VWA k59_357675_1 1122137.AQXF01000006_gene933 1.08e-106 327.0 COG4770@1|root,COG4770@2|Bacteria,1P6RE@1224|Proteobacteria,2TRC2@28211|Alphaproteobacteria 28211|Alphaproteobacteria I Acetyl propionyl-CoA carboxylase alpha subunit pccA GO:0003674,GO:0003824,GO:0004658,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0005829,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009374,GO:0009987,GO:0016421,GO:0016874,GO:0016885,GO:0017144,GO:0019752,GO:0019842,GO:0019899,GO:0031406,GO:0031974,GO:0032787,GO:0033218,GO:0033293,GO:0034641,GO:0036094,GO:0043167,GO:0043168,GO:0043177,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0043603,GO:0044237,GO:0044281,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0070013,GO:0071704,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901681 6.4.1.3 ko:K01965 ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200 M00373,M00741 R01859 RC00097,RC00609 ko00000,ko00001,ko00002,ko01000 - - - Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2 k59_413363_1 530564.Psta_1961 4.42e-14 76.6 COG1073@1|root,COG1073@2|Bacteria,2IWT8@203682|Planctomycetes 203682|Planctomycetes S alpha beta - - - - - - - - - - - - - k59_243826_1 436308.Nmar_0514 1.41e-71 224.0 COG0667@1|root,arCOG01617@2157|Archaea,41S90@651137|Thaumarchaeota 651137|Thaumarchaeota C Aldo/keto reductase family - - - - - - - - - - - - Aldo_ket_red k59_1430123_1 436308.Nmar_1772 2.61e-165 471.0 COG1509@1|root,arCOG03246@2157|Archaea,41SY6@651137|Thaumarchaeota 651137|Thaumarchaeota E TIGRFAM lysine 2,3-aminomutase YodO family protein - - - - - - - - - - - - - k59_1430123_2 436308.Nmar_1773 1.35e-92 289.0 COG0668@1|root,arCOG01568@2157|Archaea,41SYX@651137|Thaumarchaeota 651137|Thaumarchaeota M Mechanosensitive ion channel - - - ko:K05802 - - - - ko00000,ko02000 1.A.23.1.1 - - MS_channel k59_301334_2 1415778.JQMM01000001_gene1650 5.62e-11 65.1 COG1570@1|root,COG1570@2|Bacteria,1MUA4@1224|Proteobacteria,1RNAZ@1236|Gammaproteobacteria,1J4IC@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides xseA GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006308,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008855,GO:0009056,GO:0009057,GO:0009318,GO:0009987,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0019439,GO:0032991,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901361,GO:1901575,GO:1902494 3.1.11.6 ko:K03601 ko03430,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - Exonuc_VII_L,tRNA_anti_2 k59_1430124_1 926550.CLDAP_04860 1.74e-60 203.0 COG1070@1|root,COG1070@2|Bacteria 2|Bacteria G xylulokinase activity araB - 2.7.1.12,2.7.1.17,2.7.1.215,2.7.1.5 ko:K00848,ko:K00851,ko:K00854,ko:K00862 ko00030,ko00040,ko00051,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00040,map00051,map01100,map01110,map01120,map01130,map01200 M00014 R01639,R01737,R01902,R03014,R11536 RC00002,RC00017,RC00538 ko00000,ko00001,ko00002,ko01000 - - - FGGY_C,FGGY_N k59_695845_1 1333507.AUTQ01000119_gene1806 4.16e-10 60.1 COG0454@1|root,COG0456@2|Bacteria,1MVZ2@1224|Proteobacteria,1RSC5@1236|Gammaproteobacteria,2Q017@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria K Peptidase_C39 like family - - - - - - - - - - - - Acetyltransf_1,Acetyltransf_10,DUF3335 k59_695845_2 1085623.GNIT_1481 2.47e-48 162.0 COG3751@1|root,COG3751@2|Bacteria,1RD3H@1224|Proteobacteria,1S40I@1236|Gammaproteobacteria,46712@72275|Alteromonadaceae 1236|Gammaproteobacteria O 2OG-Fe(II) oxygenase - - - ko:K07394 - - - - ko00000 - - - 2OG-FeII_Oxy_3 k59_1147674_1 380358.XALC_1196 2.16e-100 303.0 COG2115@1|root,COG2115@2|Bacteria,1MXS2@1224|Proteobacteria,1RN5Y@1236|Gammaproteobacteria,1X4B9@135614|Xanthomonadales 135614|Xanthomonadales G Belongs to the xylose isomerase family xylA GO:0003674,GO:0003824,GO:0005975,GO:0005996,GO:0008150,GO:0008152,GO:0009045,GO:0009056,GO:0016052,GO:0016853,GO:0016860,GO:0016861,GO:0019321,GO:0019323,GO:0042732,GO:0042843,GO:0044238,GO:0044281,GO:0044282,GO:0046365,GO:0071704,GO:1901575 5.3.1.5 ko:K01805 ko00040,ko00051,ko01100,map00040,map00051,map01100 - R00878,R01432 RC00376,RC00516 ko00000,ko00001,ko01000 - - - - k59_1317983_1 1229909.NSED_03465 2.61e-74 233.0 COG0517@1|root,arCOG00600@2157|Archaea 2157|Archaea K CBS domain - - - ko:K07182 - - - - ko00000 - - - CBS k59_1374445_1 411684.HPDFL43_17126 6.04e-57 191.0 COG3684@1|root,COG3684@2|Bacteria,1QZI3@1224|Proteobacteria,2U07T@28211|Alphaproteobacteria,43RGP@69277|Phyllobacteriaceae 28211|Alphaproteobacteria G DeoC/LacD family aldolase MA20_09915 - 4.1.2.40,4.1.2.57 ko:K01635,ko:K01671 ko00052,ko01100,ko02024,map00052,map01100,map02024 - R01069,R10760 RC00438,RC00439 ko00000,ko00001,ko01000 - - - DeoC k59_1037167_1 1246448.ANAZ01000007_gene2147 9.56e-42 147.0 COG2513@1|root,COG2513@2|Bacteria,2GMQ4@201174|Actinobacteria 201174|Actinobacteria G COG2513 PEP phosphonomutase and related enzymes - - - - - - - - - - - - PEP_mutase k59_978586_1 1205680.CAKO01000038_gene2072 7.81e-21 92.0 COG0266@1|root,COG0266@2|Bacteria,1MVM5@1224|Proteobacteria,2TS4C@28211|Alphaproteobacteria,2JPMQ@204441|Rhodospirillales 204441|Rhodospirillales L Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates fpg - 3.2.2.23,4.2.99.18 ko:K10563 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - Fapy_DNA_glyco,H2TH,zf-FPG_IleRS k59_978594_1 1401328.P856_231 2.43e-15 72.0 COG5319@1|root,COG5319@2|Bacteria,1MZN2@1224|Proteobacteria,2UBTA@28211|Alphaproteobacteria,2JTIJ@204441|Rhodospirillales 204441|Rhodospirillales S Protein of unknown function (DUF1178) - - - - - - - - - - - - DUF1178 k59_978594_2 1122137.AQXF01000004_gene1840 5.92e-83 253.0 COG0388@1|root,COG0388@2|Bacteria,1MUUB@1224|Proteobacteria,2TRGZ@28211|Alphaproteobacteria 28211|Alphaproteobacteria K Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase MA20_39720 - - ko:K11206 - - - - ko00000,ko01000 - - - CN_hydrolase k59_978596_1 477974.Daud_0395 7.22e-36 139.0 COG3344@1|root,COG3344@2|Bacteria,1VGI0@1239|Firmicutes,24PB2@186801|Clostridia 186801|Clostridia L Reverse transcriptase (RNA-dependent DNA polymerase) - - - - - - - - - - - - RVT_1 k59_358747_1 436308.Nmar_1516 8.64e-123 365.0 COG2304@1|root,arCOG02900@2157|Archaea,41SDY@651137|Thaumarchaeota 651137|Thaumarchaeota S von Willebrand factor (vWF) type A domain - - - - - - - - - - - - - k59_1713855_1 216142.LT40_19825 4.23e-35 132.0 COG0665@1|root,COG0665@2|Bacteria,1MVIZ@1224|Proteobacteria 1224|Proteobacteria E D-Amino acid dehydrogenase thiO GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006520,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0016491,GO:0016638,GO:0016641,GO:0017144,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0036094,GO:0042364,GO:0042723,GO:0042724,GO:0043167,GO:0043168,GO:0043436,GO:0043799,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0055114,GO:0071704,GO:0071949,GO:0072527,GO:0072528,GO:0097159,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 1.4.3.19,1.4.5.1 ko:K00285,ko:K03153 ko00360,ko00730,ko01100,map00360,map00730,map01100 - R01374,R07463,R09493 RC00006,RC00025,RC01788 ko00000,ko00001,ko01000 - - - DAO k59_583882_1 247633.GP2143_04980 2.7e-26 108.0 COG0672@1|root,COG0672@2|Bacteria,1N48M@1224|Proteobacteria,1S7GF@1236|Gammaproteobacteria,1J6PW@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P COG0672 High-affinity Fe2 Pb2 permease - - - ko:K07243 - - - - ko00000,ko02000 2.A.108.1,2.A.108.2 - - FTR1 k59_640719_1 926550.CLDAP_37660 4.01e-49 165.0 COG2135@1|root,COG2135@2|Bacteria,2G74X@200795|Chloroflexi 200795|Chloroflexi S Belongs to the SOS response-associated peptidase family - - - - - - - - - - - - SRAP k59_640719_2 671143.DAMO_0659 3.4e-08 55.8 COG5373@1|root,COG5373@2|Bacteria 2|Bacteria KLT membrane - - - ko:K02451,ko:K03832 - M00331 - - ko00000,ko00002,ko02000,ko02044 2.C.1.1,9.B.42 - - T2SSB k59_1375568_1 247634.GPB2148_160 3.22e-90 274.0 COG0183@1|root,COG0183@2|Bacteria,1PSXC@1224|Proteobacteria,1RQDP@1236|Gammaproteobacteria,1J54E@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria I Belongs to the thiolase family - - - - - - - - - - - - Thiolase_C k59_302338_1 1463825.JNXC01000001_gene6210 3.93e-07 57.0 COG1404@1|root,COG1404@2|Bacteria,2GIRE@201174|Actinobacteria,4E0EP@85010|Pseudonocardiales 201174|Actinobacteria O Belongs to the peptidase S8 family mycP4 GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0009405,GO:0009986,GO:0016020,GO:0016021,GO:0016787,GO:0017171,GO:0019538,GO:0030312,GO:0031224,GO:0031226,GO:0032879,GO:0040007,GO:0043170,GO:0044238,GO:0044419,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0051046,GO:0051049,GO:0051704,GO:0065007,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564 - ko:K14743 - - - - ko00000,ko01000,ko01002,ko03110 - - - Peptidase_S8 k59_19348_1 222534.KB893728_gene5648 2.46e-62 209.0 COG0318@1|root,COG0318@2|Bacteria,2IEKP@201174|Actinobacteria,4EX2P@85013|Frankiales 201174|Actinobacteria IQ AMP-binding enzyme C-terminal domain - - - - - - - - - - - - AMP-binding,AMP-binding_C k59_1205535_1 1484460.JSWG01000006_gene2787 3.91e-67 221.0 COG1165@1|root,COG1165@2|Bacteria,4NETZ@976|Bacteroidetes,1HXR0@117743|Flavobacteriia 976|Bacteroidetes H Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) menD - 2.2.1.9 ko:K02551 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116 R08165 RC02186 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M_2,TPP_enzyme_N k59_697065_1 316407.1799910 1.03e-111 339.0 COG0651@1|root,COG0651@2|Bacteria,1MXRW@1224|Proteobacteria,1RM9Q@1236|Gammaproteobacteria,3XMXV@561|Escherichia 1236|Gammaproteobacteria CP Formate hydrogenlyase, subunit hyfB GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K05568,ko:K12137,ko:K15828 - - - - ko00000,ko01000,ko02000 2.A.63.1,2.A.63.2 - iECO111_1330.ECO111_3443,iECO26_1355.ECO26_3788,iEKO11_1354.EKO11_1252 Proton_antipo_M,Proton_antipo_N k59_244887_1 107636.JQNK01000004_gene851 2.36e-57 199.0 COG3119@1|root,COG3119@2|Bacteria,1MV92@1224|Proteobacteria,2TTXG@28211|Alphaproteobacteria,36ZG2@31993|Methylocystaceae 28211|Alphaproteobacteria P Sulfatase - - 3.1.6.1 ko:K01130 ko00140,ko00600,map00140,map00600 - R03980,R04856 RC00128,RC00231 ko00000,ko00001,ko01000 - - - Sulfatase k59_302343_1 1292034.OR37_01324 3.47e-61 204.0 COG3659@1|root,COG3659@2|Bacteria,1QMC3@1224|Proteobacteria,2TU5Q@28211|Alphaproteobacteria,2KJCM@204458|Caulobacterales 204458|Caulobacterales M Carbohydrate-selective porin - - - ko:K07267 - - - - ko00000,ko02000 1.B.19.1 - - OprB k59_640732_1 448385.sce7701 2.85e-05 51.6 COG0515@1|root,COG2203@1|root,COG3899@1|root,COG3920@1|root,COG0515@2|Bacteria,COG2203@2|Bacteria,COG3899@2|Bacteria,COG3920@2|Bacteria,1RGKE@1224|Proteobacteria 1224|Proteobacteria T GAF domain - - 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 - - - AAA_16,GAF,GAF_2,HATPase_c,HD,HWE_HK,HisKA,HisKA_3,PAS,PAS_3,PAS_4,PAS_9,Pkinase,STAS,SpoIIE k59_1431231_2 1070319.CAGGBEG34_260003 2.11e-23 92.8 COG0271@1|root,COG0271@2|Bacteria,1MZG5@1224|Proteobacteria,2VVNP@28216|Betaproteobacteria,1K8DM@119060|Burkholderiaceae 28216|Betaproteobacteria T Belongs to the BolA IbaG family bolA - - ko:K05527 - - - - ko00000,ko03000 - - - BolA k59_923161_1 207954.MED92_11509 4.31e-31 131.0 COG2199@1|root,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria,1RYYR@1236|Gammaproteobacteria,1XJFY@135619|Oceanospirillales 135619|Oceanospirillales T Diguanylate cyclase - - - - - - - - - - - - CHASE,GAF_2,GGDEF,PAS_8 k59_471014_1 1499967.BAYZ01000001_gene5910 1.07e-42 161.0 COG0525@1|root,COG0525@2|Bacteria,2NNKR@2323|unclassified Bacteria 2|Bacteria J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner valS GO:0000287,GO:0002161,GO:0003674,GO:0003824,GO:0004812,GO:0004832,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006417,GO:0006418,GO:0006438,GO:0006450,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0016070,GO:0016787,GO:0016788,GO:0016874,GO:0016875,GO:0019222,GO:0019538,GO:0019752,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0034248,GO:0034250,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045727,GO:0045903,GO:0046483,GO:0046872,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0052689,GO:0060255,GO:0061475,GO:0065007,GO:0065008,GO:0071704,GO:0080090,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:2000112 6.1.1.9 ko:K01873 ko00970,map00970 M00359,M00360 R03665 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iECH74115_1262.ECH74115_5779,iECNA114_1301.ECNA114_4481,iECO26_1355.ECO26_5428,iECSP_1301.ECSP_5359,iECs_1301.ECs5235,iG2583_1286.G2583_5088,iJN746.PP_0977,iSBO_1134.SBO_4182,iSSON_1240.SSON_4443,iYL1228.KPN_04663,iZ_1308.Z5870 Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1 k59_640737_1 1054213.HMPREF9946_02527 1.29e-15 80.9 COG4307@1|root,COG4307@2|Bacteria,1MW31@1224|Proteobacteria,2TRR9@28211|Alphaproteobacteria,2JQCY@204441|Rhodospirillales 204441|Rhodospirillales S Putative zinc-binding metallo-peptidase - - - - - - - - - - - - Peptidase_Mx,zinc-ribbon_6 k59_19357_1 195253.Syn6312_1107 5.63e-27 108.0 COG0863@1|root,COG0863@2|Bacteria,1G911@1117|Cyanobacteria 1117|Cyanobacteria L Belongs to the N(4) N(6)-methyltransferase family - - 2.1.1.113 ko:K00590 - - - - ko00000,ko01000,ko02048 - - - N6_N4_Mtase k59_19357_2 1035189.HMPREF9954_0971 5.64e-17 80.9 COG0818@1|root,COG1159@1|root,COG0818@2|Bacteria,COG1159@2|Bacteria,1TP3R@1239|Firmicutes,4H9WF@91061|Bacilli,43FSU@68892|Streptococcus infantis 91061|Bacilli M An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism era GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006275,GO:0008150,GO:0008156,GO:0009889,GO:0009890,GO:0009892,GO:0010556,GO:0010558,GO:0010605,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019003,GO:0019219,GO:0019222,GO:0030174,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032297,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0045934,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051052,GO:0051053,GO:0051171,GO:0051172,GO:0051302,GO:0051781,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:0090329,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:2000104,GO:2000112,GO:2000113 - ko:K03595 - - - - ko00000,ko03009,ko03029 - - - KH_2,MMR_HSR1 k59_1318947_1 85643.Tmz1t_2945 2.15e-43 150.0 COG0454@1|root,COG0456@2|Bacteria,1RGZ2@1224|Proteobacteria,2VXB4@28216|Betaproteobacteria,2KXES@206389|Rhodocyclales 206389|Rhodocyclales K Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_1 k59_753492_1 859657.RPSI07_1003 1.55e-10 69.3 COG3209@1|root,COG3209@2|Bacteria,1N632@1224|Proteobacteria,2W29H@28216|Betaproteobacteria,1K3S1@119060|Burkholderiaceae 28216|Betaproteobacteria M Participates in initiation and elongation during chromosome replication - - - - - - - - - - - - RHS_repeat k59_978647_1 382464.ABSI01000012_gene2279 1.72e-25 103.0 COG0224@1|root,COG0224@2|Bacteria,46SGU@74201|Verrucomicrobia,2ITXP@203494|Verrucomicrobiae 203494|Verrucomicrobiae C Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex atpG - - ko:K02115 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt k59_978647_2 382464.ABSI01000012_gene2280 3.65e-58 194.0 COG0055@1|root,COG0055@2|Bacteria,46SCC@74201|Verrucomicrobia,2IU0R@203494|Verrucomicrobiae 203494|Verrucomicrobiae C Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits atpD - 3.6.3.14 ko:K02112 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - - ATP-synt_ab,ATP-synt_ab_N k59_697075_1 43759.JNWK01000040_gene2272 3.23e-17 85.9 COG3629@1|root,COG5516@1|root,COG3629@2|Bacteria,COG5516@2|Bacteria,2HEH7@201174|Actinobacteria 201174|Actinobacteria T CGNR zinc finger - - - - - - - - - - - - ABATE,BTAD,Trans_reg_C,zf-CGNR k59_978651_1 1208583.COMX_07475 1.49e-39 142.0 COG2197@1|root,COG2197@2|Bacteria,1P4TD@1224|Proteobacteria,2U06A@28211|Alphaproteobacteria,2JRXM@204441|Rhodospirillales 204441|Rhodospirillales T COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain - - - - - - - - - - - - GerE,Response_reg k59_923191_1 316407.85675554 6.29e-112 344.0 COG0249@1|root,COG0249@2|Bacteria,1MUGX@1224|Proteobacteria,1RNW3@1236|Gammaproteobacteria,3XMSY@561|Escherichia 1236|Gammaproteobacteria L that it carries out the mismatch recognition step. This protein has a weak ATPase activity mutS GO:0000018,GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0008301,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019219,GO:0019222,GO:0030554,GO:0030983,GO:0031323,GO:0032136,GO:0032300,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033554,GO:0034641,GO:0035639,GO:0036094,GO:0042623,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0043531,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051171,GO:0051716,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901363,GO:1990391 - ko:K03555 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - iECW_1372.ECW_m2935,iWFL_1372.ECW_m2935 MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V k59_1713893_1 1229909.NSED_09340 3.52e-39 142.0 COG0527@1|root,arCOG00861@2157|Archaea,41SFA@651137|Thaumarchaeota 651137|Thaumarchaeota E Belongs to the aspartokinase family - - 2.7.2.4 ko:K00928 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00017,M00018,M00033,M00525,M00526,M00527 R00480 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase,ACT_7 k59_1713893_2 1229909.NSED_06400 6.87e-09 58.9 COG3794@1|root,arCOG08764@1|root,arCOG02926@2157|Archaea,arCOG08764@2157|Archaea 2157|Archaea C PFAM blue (type 1) copper domain protein - - - - - - - - - - - - Copper-bind k59_867530_1 1122137.AQXF01000001_gene3237 4.71e-16 76.6 COG0486@1|root,COG0486@2|Bacteria,1MUCQ@1224|Proteobacteria,2TQZW@28211|Alphaproteobacteria 28211|Alphaproteobacteria J Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 mnmE - - ko:K03650 - - R08701 RC00053,RC00209,RC00870 ko00000,ko01000,ko03016 - - - MMR_HSR1,MnmE_helical,TrmE_N k59_867530_2 1122137.AQXF01000001_gene3236 2.3e-92 288.0 COG0445@1|root,COG0445@2|Bacteria,1MU6F@1224|Proteobacteria,2TRJS@28211|Alphaproteobacteria 28211|Alphaproteobacteria D NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 gidA GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901363 - ko:K03495 - - R08701 RC00053,RC00209,RC00870 ko00000,ko03016,ko03036 - - - GIDA,GIDA_assoc k59_1157229_3 443143.GM18_3230 1.7e-13 73.2 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42P5K@68525|delta/epsilon subdivisions,2WIKI@28221|Deltaproteobacteria,43UH9@69541|Desulfuromonadales 28221|Deltaproteobacteria T Bacterial regulatory protein, Fis family - - - ko:K02481 - - - - ko00000,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_760178_1 981223.AIED01000006_gene3443 6.49e-125 382.0 COG2801@1|root,COG2801@2|Bacteria,1MXCK@1224|Proteobacteria,1RV69@1236|Gammaproteobacteria,3NJEH@468|Moraxellaceae 1236|Gammaproteobacteria L Mu transposase, C-terminal - - - ko:K07497 - - - - ko00000 - - - HTH_28,HTH_29,HTH_Tnp_Mu_2,Mu-transpos_C,rve k59_706614_1 743722.Sph21_1354 5.52e-48 172.0 COG0469@1|root,COG0469@2|Bacteria,4NEEU@976|Bacteroidetes,1IPRW@117747|Sphingobacteriia 976|Bacteroidetes G Belongs to the pyruvate kinase family pyk - 2.7.1.40 ko:K00873 ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230 M00001,M00002,M00049,M00050 R00200,R00430,R01138,R01858,R02320 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - PK,PK_C k59_706614_2 1337936.IJ00_10310 2.52e-56 183.0 COG1830@1|root,COG1830@2|Bacteria,1G1ER@1117|Cyanobacteria,1HKSS@1161|Nostocales 1117|Cyanobacteria G PFAM deoxyribose-phosphate aldolase phospho-2-dehydro-3-deoxyheptonate aldolase fbaB - 4.1.2.13 ko:K11645 ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00003 R01068,R01070,R01829,R02568 RC00438,RC00439,RC00603,RC00604 ko00000,ko00001,ko00002,ko01000 - - - DeoC k59_533266_1 1158345.JNLL01000001_gene1887 1.39e-07 54.3 COG4795@1|root,COG4795@2|Bacteria,2G47B@200783|Aquificae 200783|Aquificae U Prokaryotic N-terminal methylation motif - - - ko:K02672 - - - - ko00000,ko02035,ko02044 - - - N_methyl k59_533266_2 909663.KI867149_gene3439 3.3e-08 55.8 COG4967@1|root,COG4967@2|Bacteria,1NHY3@1224|Proteobacteria,42WZH@68525|delta/epsilon subdivisions,2WSKR@28221|Deltaproteobacteria 28221|Deltaproteobacteria NU Prokaryotic N-terminal methylation motif pilV-2 - - ko:K02671 - - - - ko00000,ko02035,ko02044 - - - N_methyl k59_1610904_1 378806.STAUR_4390 1.45e-99 318.0 COG0249@1|root,COG0249@2|Bacteria,1MUGX@1224|Proteobacteria,42MRR@68525|delta/epsilon subdivisions,2WIQ7@28221|Deltaproteobacteria,2YTZJ@29|Myxococcales 28221|Deltaproteobacteria L that it carries out the mismatch recognition step. This protein has a weak ATPase activity mutS GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - ko:K03555 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V k59_368776_1 420324.KI912022_gene337 1.66e-24 103.0 COG4302@1|root,COG4303@1|root,COG4302@2|Bacteria,COG4303@2|Bacteria,1MUR4@1224|Proteobacteria,2TTNA@28211|Alphaproteobacteria,1JT3I@119045|Methylobacteriaceae 28211|Alphaproteobacteria E PFAM Ethanolamine ammonia lyase large subunit eutB - 4.3.1.7 ko:K03735 ko00564,ko01100,map00564,map01100 - R00749 RC00370 ko00000,ko00001,ko01000 - - - EutB k59_1438217_1 1122137.AQXF01000005_gene1215 2.26e-70 220.0 COG4221@1|root,COG4221@2|Bacteria,1QTXD@1224|Proteobacteria,2TW4Q@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Belongs to the short-chain dehydrogenases reductases (SDR) family - - - - - - - - - - - - adh_short k59_1438217_2 1122137.AQXF01000005_gene1216 1.94e-46 159.0 COG0657@1|root,COG0657@2|Bacteria,1RD8A@1224|Proteobacteria,2U1B8@28211|Alphaproteobacteria 28211|Alphaproteobacteria I Alpha beta hydrolase - - - - - - - - - - - - Abhydrolase_3 k59_877102_1 488538.SAR116_0014 3.27e-10 60.1 COG0719@1|root,COG0719@2|Bacteria,1MVKY@1224|Proteobacteria,2TRU6@28211|Alphaproteobacteria,4BPG7@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria O FeS assembly protein SufB sufB GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0009536,GO:0009842,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464 - ko:K09014 - - - - ko00000 - - - UPF0051 k59_877102_2 1122137.AQXF01000004_gene1439 9.57e-59 186.0 COG1959@1|root,COG1959@2|Bacteria,1N0E2@1224|Proteobacteria,2U9Z9@28211|Alphaproteobacteria 28211|Alphaproteobacteria K transcriptional regulator - - - - - - - - - - - - Rrf2 k59_877102_3 1122137.AQXF01000004_gene1440 2.62e-72 228.0 COG1071@1|root,COG1071@2|Bacteria,1MU5R@1224|Proteobacteria,2UQUA@28211|Alphaproteobacteria 28211|Alphaproteobacteria C Dehydrogenase E1 component - - - ko:K21416 - - - - ko00000,ko01000 - - - E1_dh k59_29306_2 404589.Anae109_0935 3.89e-61 198.0 COG0330@1|root,COG0330@2|Bacteria,1MUM8@1224|Proteobacteria,42NX0@68525|delta/epsilon subdivisions,2WKYT@28221|Deltaproteobacteria 28221|Deltaproteobacteria O PFAM Band 7 protein - - - - - - - - - - - - Band_7,Band_7_C k59_533287_1 1408436.JHXY01000006_gene2015 4.09e-29 120.0 COG0439@1|root,COG0439@2|Bacteria,1TP16@1239|Firmicutes,25E48@186801|Clostridia,25V5Q@186806|Eubacteriaceae 186801|Clostridia I Acetyl-CoA carboxylase, biotin carboxylase subunit accC - 6.3.4.14,6.3.4.6,6.4.1.2 ko:K01941,ko:K01961 ko00061,ko00220,ko00620,ko00640,ko00720,ko00791,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00220,map00620,map00640,map00720,map00791,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R00774,R04385 RC00040,RC00253,RC00367,RC00378 ko00000,ko00001,ko00002,ko01000 - - - Biotin_carb_C,Biotin_carb_N,CPSase_L_D2 k59_816767_1 426355.Mrad2831_2401 1.89e-117 360.0 COG4670@1|root,COG4670@2|Bacteria,1MUJW@1224|Proteobacteria,2TRRK@28211|Alphaproteobacteria,1JR1Y@119045|Methylobacteriaceae 28211|Alphaproteobacteria I PFAM Coenzyme A transferase pct - 2.8.3.1 ko:K01026 ko00620,ko00640,ko00643,ko01100,ko01120,map00620,map00640,map00643,map01100,map01120 - R00928,R01449,R05508 RC00012,RC00014,RC00137 ko00000,ko00001,ko01000 - - - CoA_trans k59_593392_1 1169143.KB911041_gene661 1.35e-24 104.0 COG1009@1|root,COG1009@2|Bacteria,1MW2M@1224|Proteobacteria,2VJ2J@28216|Betaproteobacteria,1K0MD@119060|Burkholderiaceae 28216|Betaproteobacteria C NADH-Ubiquinone oxidoreductase (complex I) chain 5 L domain protein nuoL - 1.6.5.3 ko:K00341 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Proton_antipo_C,Proton_antipo_M,Proton_antipo_N k59_593392_2 1123518.ARWI01000001_gene2265 2.73e-09 58.5 COG1008@1|root,COG1008@2|Bacteria,1MV7V@1224|Proteobacteria,1RNI4@1236|Gammaproteobacteria,4602R@72273|Thiotrichales 72273|Thiotrichales C NADH-quinone oxidoreductase, chain M - - 1.6.5.3 ko:K00342 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q5_N,Proton_antipo_M k59_423278_1 760192.Halhy_2991 4.13e-23 98.6 COG0083@1|root,COG0083@2|Bacteria,4NE2M@976|Bacteroidetes,1IP1D@117747|Sphingobacteriia 976|Bacteroidetes E Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate thrB - 2.7.1.39 ko:K00872 ko00260,ko01100,ko01110,ko01120,ko01230,map00260,map01100,map01110,map01120,map01230 M00018 R01771 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - GHMP_kinases_C,GHMP_kinases_N k59_423278_2 1131451.O1K_18278 5.15e-52 184.0 COG0460@1|root,COG0527@1|root,COG0460@2|Bacteria,COG0527@2|Bacteria,1MW3H@1224|Proteobacteria,1RN1G@1236|Gammaproteobacteria,1X4R3@135614|Xanthomonadales 135614|Xanthomonadales E homoserine dehydrogenase thrA - 1.1.1.3,2.7.2.4 ko:K12524 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00017,M00018,M00526,M00527 R00480,R01773,R01775 RC00002,RC00043,RC00087 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase,ACT,ACT_7,Homoserine_dh,NAD_binding_3 k59_818046_2 396588.Tgr7_0029 1.36e-29 115.0 COG0181@1|root,COG0181@2|Bacteria,1MU56@1224|Proteobacteria,1RMQ8@1236|Gammaproteobacteria,1WVWF@135613|Chromatiales 135613|Chromatiales H Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps hemC - 2.5.1.61 ko:K01749 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R00084 RC02317 ko00000,ko00001,ko00002,ko01000 - - - Porphobil_deam,Porphobil_deamC k59_534194_1 489825.LYNGBM3L_42570 8.04e-06 47.8 COG0745@1|root,COG2114@1|root,COG5002@1|root,COG0745@2|Bacteria,COG2114@2|Bacteria,COG5002@2|Bacteria,1GHFQ@1117|Cyanobacteria,1H9WN@1150|Oscillatoriales 1117|Cyanobacteria T 7TM diverse intracellular signalling - - - ko:K19694 - - - - ko00000,ko01001,ko02022 - - - 7TMR-DISM_7TM,Guanylate_cyc,HAMP,HATPase_c,HisKA,PAS_9,Response_reg,dCache_1 k59_534194_2 246197.MXAN_5784 2.28e-29 119.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,2YUJ9@29|Myxococcales 28221|Deltaproteobacteria T Response regulator containing CheY-like receiver AAA-type ATPase and DNA-binding domains pilR - - ko:K02667 ko02020,map02020 M00501 - - ko00000,ko00001,ko00002,ko02022,ko02035 - - - HTH_8,Response_reg,Sigma54_activat k59_1439224_1 391625.PPSIR1_03113 1.55e-64 225.0 COG1752@1|root,COG1752@2|Bacteria,1Q82E@1224|Proteobacteria,434UN@68525|delta/epsilon subdivisions,2WZ5Q@28221|Deltaproteobacteria,2Z1DT@29|Myxococcales 28221|Deltaproteobacteria S Esterase of the alpha-beta hydrolase superfamily - - - - - - - - - - - - - k59_1386528_1 1131266.ARWQ01000001_gene1367 2.7e-18 84.0 COG0652@1|root,arCOG04767@2157|Archaea,41T0W@651137|Thaumarchaeota 651137|Thaumarchaeota O Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD - - 5.2.1.8 ko:K03768 - - - - ko00000,ko01000,ko03110 - - - Pro_isomerase k59_197708_1 436308.Nmar_0714 4e-48 168.0 arCOG00373@1|root,arCOG00373@2157|Archaea,41ST8@651137|Thaumarchaeota 651137|Thaumarchaeota L ATPase involved in DNA repair - - - - - - - - - - - - - k59_1777223_1 1122137.AQXF01000001_gene2737 4.37e-180 513.0 COG0397@1|root,COG0397@2|Bacteria,1MVK3@1224|Proteobacteria,2TT84@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Belongs to the UPF0061 (SELO) family - - - - - - - - - - - - UPF0061 k59_30572_1 1121033.AUCF01000011_gene1791 2.21e-212 607.0 COG1123@1|root,COG4172@2|Bacteria,1MU09@1224|Proteobacteria,2TQP0@28211|Alphaproteobacteria,2JQ4Z@204441|Rhodospirillales 204441|Rhodospirillales P Belongs to the ABC transporter superfamily - - - ko:K13896 ko02010,map02010 M00349 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5.21,3.A.1.5.24 - - ABC_tran,oligo_HPY k59_761146_2 1313172.YM304_12960 7.17e-72 229.0 COG2267@1|root,COG2267@2|Bacteria,2I79Z@201174|Actinobacteria 201174|Actinobacteria I Serine aminopeptidase, S33 - - - - - - - - - - - - Abhydrolase_1 k59_1666543_1 551789.ATVJ01000001_gene1670 6.74e-137 407.0 COG2272@1|root,COG2272@2|Bacteria,1MVQZ@1224|Proteobacteria,2TUA9@28211|Alphaproteobacteria,43WY0@69657|Hyphomonadaceae 28211|Alphaproteobacteria I Belongs to the type-B carboxylesterase lipase family - - - ko:K03929 - - - - ko00000,ko01000 - CE10 - COesterase k59_1100878_2 675813.VIB_002511 6.72e-19 85.5 COG1683@1|root,COG3272@1|root,COG1683@2|Bacteria,COG3272@2|Bacteria,1MXYZ@1224|Proteobacteria,1RNMF@1236|Gammaproteobacteria,1XUJK@135623|Vibrionales 135623|Vibrionales S Protein of unknown function (DUF1722) - - - - - - - - - - - - DUF1722,DUF523 k59_878413_1 1046714.AMRX01000003_gene412 4.31e-26 108.0 COG2089@1|root,COG2089@2|Bacteria,1MWG3@1224|Proteobacteria,1RPIG@1236|Gammaproteobacteria,464CM@72275|Alteromonadaceae 1236|Gammaproteobacteria M COG2089 Sialic acid synthase neuB - 2.5.1.56 ko:K01654 ko00520,ko01100,map00520,map01100 - R01804,R04435 RC00159 ko00000,ko00001,ko01000 - - - NeuB,SAF k59_878413_2 667014.Thein_0736 2.58e-24 107.0 COG1083@1|root,COG3980@1|root,COG1083@2|Bacteria,COG3980@2|Bacteria 2|Bacteria M transferase activity, transferring hexosyl groups spsG - 2.7.7.43 ko:K00983 ko00520,ko01100,map00520,map01100 - R01117,R04215 RC00152 ko00000,ko00001,ko01000 - - - CTP_transf_3,Glyco_tran_28_C k59_1777245_1 717231.Flexsi_0566 3.26e-35 132.0 COG1131@1|root,COG1131@2|Bacteria,2GFPC@200930|Deferribacteres 200930|Deferribacteres V ABC transporter - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_1556686_1 608538.HTH_1527 1.29e-14 73.9 COG0247@1|root,COG0247@2|Bacteria 2|Bacteria C lactate metabolic process glpC GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0008150,GO:0008152,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0022900,GO:0043167,GO:0043169,GO:0044237,GO:0044464,GO:0045333,GO:0046872,GO:0048037,GO:0051536,GO:0051540,GO:0055114,GO:0071944 1.1.5.3 ko:K00113 ko00564,ko01110,map00564,map01110 - R00848 RC00029 ko00000,ko00001,ko01000 - - - CCG,DUF3501,Fer4_8 k59_1556686_2 502025.Hoch_2201 6.59e-82 244.0 COG1592@1|root,COG1592@2|Bacteria,1R9WG@1224|Proteobacteria,42N9V@68525|delta/epsilon subdivisions,2WJWQ@28221|Deltaproteobacteria,2YV2V@29|Myxococcales 28221|Deltaproteobacteria C Rubrerythrin rbr GO:0003674,GO:0005488,GO:0005506,GO:0043167,GO:0043169,GO:0046872,GO:0046914 - - - - - - - - - - Rubrerythrin k59_648598_1 977880.RALTA_A0747 1.19e-77 242.0 COG1840@1|root,COG1840@2|Bacteria,1MUEG@1224|Proteobacteria,2VHI6@28216|Betaproteobacteria,1JZVS@119060|Burkholderiaceae 28216|Betaproteobacteria P Bacterial extracellular solute-binding protein fbpA - - ko:K02012 ko02010,map02010 M00190 - - ko00000,ko00001,ko00002,ko02000 3.A.1.10 - - SBP_bac_6,SBP_bac_8 k59_878432_1 1210884.HG799464_gene11229 0.000122 49.3 COG0500@1|root,COG2226@2|Bacteria,2IYB6@203682|Planctomycetes 203682|Planctomycetes Q Methylase involved in ubiquinone menaquinone - - - - - - - - - - - - Methyltransf_31 k59_478888_1 1229909.NSED_02495 7.82e-127 370.0 COG0520@1|root,arCOG00065@2157|Archaea,41SCV@651137|Thaumarchaeota 651137|Thaumarchaeota E Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine - - 2.8.1.7,4.4.1.16 ko:K11717 ko00450,ko01100,map00450,map01100 - R03599,R11528 RC00961,RC01789,RC02313 ko00000,ko00001,ko01000 - - - Aminotran_5 k59_648602_1 158500.BV97_00947 1.99e-20 87.0 COG1214@1|root,COG1214@2|Bacteria,1MXPH@1224|Proteobacteria,2TTM2@28211|Alphaproteobacteria,2K59A@204457|Sphingomonadales 204457|Sphingomonadales O peptidase M22 - - - - - - - - - - - - Peptidase_M22 k59_648602_2 702113.PP1Y_AT19306 1.56e-96 284.0 COG0694@1|root,COG0694@2|Bacteria,1MVQ1@1224|Proteobacteria,2TUD1@28211|Alphaproteobacteria,2K0IN@204457|Sphingomonadales 204457|Sphingomonadales O COG0694 Thioredoxin-like proteins and domains - - - - - - - - - - - - Nfu_N,NifU k59_1499858_2 1089552.KI911559_gene869 2.53e-13 68.6 COG2081@1|root,COG2081@2|Bacteria,1MUGC@1224|Proteobacteria,2TTXA@28211|Alphaproteobacteria,2JP9F@204441|Rhodospirillales 204441|Rhodospirillales S HI0933-like protein - - - ko:K07007 - - - - ko00000 - - - HI0933_like k59_87751_1 1096930.L284_04295 3.52e-46 161.0 COG0451@1|root,COG0451@2|Bacteria,1RFTQ@1224|Proteobacteria,2U7DK@28211|Alphaproteobacteria,2K51T@204457|Sphingomonadales 204457|Sphingomonadales GM GDP-mannose 4,6 dehydratase - - - - - - - - - - - - Epimerase k59_1556696_1 1197477.IA57_09945 3.69e-167 487.0 COG0514@1|root,COG0514@2|Bacteria,4NEB4@976|Bacteroidetes,1HXCJ@117743|Flavobacteriia 976|Bacteroidetes L ATP-dependent DNA helicase RecQ recQ - 3.6.4.12 ko:K03654 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,HRDC,Helicase_C,RQC,RecQ_Zn_bind k59_648604_1 1054213.HMPREF9946_04906 3.1e-42 148.0 COG3836@1|root,COG3836@2|Bacteria,1RAYB@1224|Proteobacteria,2U6PQ@28211|Alphaproteobacteria,2JWG7@204441|Rhodospirillales 204441|Rhodospirillales G HpcH/HpaI aldolase/citrate lyase family - - - - - - - - - - - - HpcH_HpaI k59_594785_1 314254.OA2633_05671 5.59e-50 175.0 COG3653@1|root,COG3653@2|Bacteria,1MWWY@1224|Proteobacteria,2TT5E@28211|Alphaproteobacteria,43Z1B@69657|Hyphomonadaceae 28211|Alphaproteobacteria Q Amidohydrolase family MA20_04810 - 3.5.1.82 ko:K01461 - - - - ko00000,ko01000 - - - Amidohydro_3 k59_594785_2 1122137.AQXF01000001_gene2607 8.99e-31 120.0 COG1629@1|root,COG4771@2|Bacteria,1MVFB@1224|Proteobacteria,2U2KS@28211|Alphaproteobacteria 28211|Alphaproteobacteria P TonB-dependent receptor plug - - - - - - - - - - - - Plug,TonB_dep_Rec k59_648610_1 981384.AEYW01000024_gene3961 7.68e-32 129.0 COG0515@1|root,COG0515@2|Bacteria,1QA6R@1224|Proteobacteria,2TS3G@28211|Alphaproteobacteria,4NDS6@97050|Ruegeria 28211|Alphaproteobacteria KLT Protein kinase domain - - - - - - - - - - - - NERD,Pkinase k59_197769_1 1415778.JQMM01000001_gene1841 2.65e-22 97.4 COG2812@1|root,COG2812@2|Bacteria,1MVCK@1224|Proteobacteria,1RMIA@1236|Gammaproteobacteria,1J4KC@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity dnaX GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030234,GO:0030337,GO:0032991,GO:0034641,GO:0034645,GO:0042575,GO:0042802,GO:0043170,GO:0043846,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050790,GO:0061695,GO:0065007,GO:0065009,GO:0071704,GO:0090304,GO:0098772,GO:1901360,GO:1901576,GO:1902494,GO:1990234 2.7.7.7 ko:K02343 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_delta2,DNA_pol3_gamma3,DNA_pol3_tau_4,DNA_pol3_tau_5 k59_1439272_1 634452.APA01_00440 3.22e-150 434.0 COG0468@1|root,COG0468@2|Bacteria,1MU3C@1224|Proteobacteria,2TRPR@28211|Alphaproteobacteria,2JPIZ@204441|Rhodospirillales 204441|Rhodospirillales L Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage recA - - ko:K03553 ko03440,map03440 M00729 - - ko00000,ko00001,ko00002,ko03400 - - - RecA k59_818127_1 449447.MAE_22920 2.09e-14 74.7 COG1612@1|root,COG1612@2|Bacteria,1G08Q@1117|Cyanobacteria 1117|Cyanobacteria O cytochrome oxidase assembly ctaA - - ko:K02259 ko00190,ko00860,ko01100,ko01110,ko02020,ko04714,map00190,map00860,map01100,map01110,map02020,map04714 M00154 R07412 RC00769 ko00000,ko00001,ko00002,ko03029 3.D.4.4 - - COX15-CtaA k59_534247_1 888727.HMPREF9092_0159 1.02e-20 95.5 COG0332@1|root,COG0332@2|Bacteria,1TP0K@1239|Firmicutes,248V8@186801|Clostridia,3WCVT@538999|Clostridiales incertae sedis 186801|Clostridia I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids - - - - - - - - - - - - ACP_syn_III,ACP_syn_III_C k59_87789_1 572477.Alvin_2418 5.03e-80 255.0 COG1008@1|root,COG1008@2|Bacteria,1MV7V@1224|Proteobacteria,1RNI4@1236|Gammaproteobacteria,1WXM2@135613|Chromatiales 135613|Chromatiales C TIGRFAM proton-translocating NADH-quinone oxidoreductase, chain M - - 1.6.5.3 ko:K00342 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q5_N,Proton_antipo_M k59_1556741_1 452662.SJA_C1-18900 3.6e-72 237.0 COG4206@1|root,COG4206@2|Bacteria,1MUZG@1224|Proteobacteria,2TUNP@28211|Alphaproteobacteria,2K1AW@204457|Sphingomonadales 204457|Sphingomonadales H receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_761202_1 1219080.VEZ01S_58_00020 5.49e-18 78.6 COG0818@1|root,COG0818@2|Bacteria,1MZ3Q@1224|Proteobacteria,1S92I@1236|Gammaproteobacteria,1XXSV@135623|Vibrionales 135623|Vibrionales M Recycling of diacylglycerol produced during the turnover of membrane phospholipid dgkA - 2.7.1.107 ko:K00901 ko00561,ko00564,ko01100,ko01110,ko04070,ko04072,ko05231,map00561,map00564,map01100,map01110,map04070,map04072,map05231 - R02240 RC00002,RC00017 ko00000,ko00001,ko01000 - - - DAGK_prokar k59_87796_1 551275.KB899544_gene1791 7.48e-30 122.0 COG0624@1|root,COG0624@2|Bacteria,1MUSU@1224|Proteobacteria,2TRTW@28211|Alphaproteobacteria,43WPY@69657|Hyphomonadaceae 28211|Alphaproteobacteria E COG0624 Acetylornithine deacetylase Succinyl-diaminopimelate desuccinylase and related deacylases MA20_32325 - 3.4.17.11 ko:K01295 - - - - ko00000,ko01000,ko01002 - - - M20_dimer,Peptidase_M20,Peptidase_M28 k59_142501_1 1229909.NSED_00745 3.26e-95 283.0 COG0107@1|root,arCOG00617@2157|Archaea,41S9A@651137|Thaumarchaeota 651137|Thaumarchaeota E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit hisF - - ko:K02500 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04558 RC00010,RC01190,RC01943 ko00000,ko00001,ko00002,ko01000 - - - His_biosynth k59_1499907_1 76636.JOEC01000002_gene2061 4.41e-12 72.0 COG0841@1|root,COG0841@2|Bacteria,2GMQX@201174|Actinobacteria,4FK8V@85023|Microbacteriaceae 201174|Actinobacteria V AcrB/AcrD/AcrF family - - - ko:K03296 - - - - ko00000 2.A.6.2 - - ACR_tran k59_1047797_1 420662.Mpe_A3745 9.73e-196 553.0 COG0334@1|root,COG0334@2|Bacteria,1MUMF@1224|Proteobacteria,2VIZ7@28216|Betaproteobacteria,1KKAP@119065|unclassified Burkholderiales 28216|Betaproteobacteria C Belongs to the Glu Leu Phe Val dehydrogenases family gdhA - 1.4.1.2,1.4.1.3 ko:K00260,ko:K00261 ko00220,ko00250,ko00430,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00430,map00471,map00910,map01100,map01200,map04217,map04964 M00740 R00243,R00248 RC00006,RC02799 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ELFV_dehydrog,ELFV_dehydrog_N k59_818161_1 876044.IMCC3088_732 1.36e-08 54.7 COG0017@1|root,COG0017@2|Bacteria,1MWFV@1224|Proteobacteria,1RMU4@1236|Gammaproteobacteria,1J4C6@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J COG0017 Aspartyl asparaginyl-tRNA synthetases asnS GO:0000166,GO:0003674,GO:0003824,GO:0004812,GO:0004816,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006421,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.1.1.22 ko:K01893 ko00970,map00970 M00359,M00360 R03648 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iSDY_1059.SDY_2327 tRNA-synt_2,tRNA_anti-codon k59_931005_1 1229909.NSED_04250 6.98e-180 516.0 COG0168@1|root,COG0517@1|root,arCOG00606@2157|Archaea,arCOG04145@2157|Archaea,41SZ8@651137|Thaumarchaeota 651137|Thaumarchaeota P CBS domain - - - ko:K03498 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - - CBS,TrkH k59_87813_1 1121887.AUDK01000001_gene665 5.91e-150 439.0 COG0591@1|root,COG0591@2|Bacteria,4NEN8@976|Bacteroidetes,1HYVB@117743|Flavobacteriia,2NYPU@237|Flavobacterium 976|Bacteroidetes E Sodium:solute symporter family - - - ko:K03307 - - - - ko00000 2.A.21 - - SSF k59_1326732_1 926569.ANT_19840 2.26e-65 204.0 COG0035@1|root,COG0035@2|Bacteria,2G6CS@200795|Chloroflexi 200795|Chloroflexi F Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate upp - 2.4.2.9 ko:K00761 ko00240,ko01100,map00240,map01100 - R00966 RC00063 ko00000,ko00001,ko01000 - - - UPRTase k59_1326732_2 997346.HMPREF9374_2952 9.15e-15 77.0 COG2208@1|root,COG2208@2|Bacteria,1TQY5@1239|Firmicutes,4HAF6@91061|Bacilli,27BGS@186824|Thermoactinomycetaceae 91061|Bacilli KT Phosphoserine phosphatase RsbU, N-terminal domain rsbU - 3.1.3.3 ko:K07315 - - - - ko00000,ko01000,ko03021 - - - RsbU_N,SpoIIE k59_878510_1 247634.GPB2148_1223 2.08e-136 407.0 COG0446@1|root,COG1902@1|root,COG0446@2|Bacteria,COG1902@2|Bacteria,1MVE0@1224|Proteobacteria,1RNM8@1236|Gammaproteobacteria,1J5K6@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C NADH:flavin oxidoreductase / NADH oxidase family - - 1.3.1.34 ko:K00219 - - - - ko00000,ko01000 - - - Oxidored_FMN,Pyr_redox_2 k59_478939_1 1144305.PMI02_02760 1.06e-152 442.0 COG2211@1|root,COG2211@2|Bacteria 2|Bacteria G Major facilitator Superfamily - - - ko:K03292 - - - - ko00000 2.A.2 - - MFS_2 k59_986806_1 93220.LV28_13530 6.74e-27 109.0 COG0737@1|root,COG0737@2|Bacteria,1MX03@1224|Proteobacteria,2VJTS@28216|Betaproteobacteria,1K2Y9@119060|Burkholderiaceae 28216|Betaproteobacteria F Belongs to the 5'-nucleotidase family soxB - 3.1.3.5,3.6.1.45 ko:K11751,ko:K17224 ko00230,ko00240,ko00760,ko00920,ko01100,ko01110,ko01120,map00230,map00240,map00760,map00920,map01100,map01110,map01120 M00595 R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346,R10151 RC00017,RC03151,RC03152 ko00000,ko00001,ko00002,ko01000 - - - 5_nucleotid_C k59_986806_2 671143.DAMO_3166 2.17e-21 94.4 COG0845@1|root,COG0845@2|Bacteria,2NPBH@2323|unclassified Bacteria 2|Bacteria M Barrel-sandwich domain of CusB or HlyD membrane-fusion macA_1 - - ko:K02005,ko:K13888 - M00709 - - ko00000,ko00002,ko02000 8.A.1 - - HlyD_D23 k59_708078_1 292564.Cyagr_0270 5.91e-32 128.0 COG2801@1|root,COG2963@1|root,COG2801@2|Bacteria,COG2963@2|Bacteria,1G5RM@1117|Cyanobacteria,22TJX@167375|Cyanobium 1117|Cyanobacteria L Integrase core domain - - - - - - - - - - - - HTH_23,HTH_32,rve k59_1499930_2 1304275.C41B8_14395 1.27e-72 222.0 COG0494@1|root,COG0494@2|Bacteria,1RDGJ@1224|Proteobacteria,1S3PQ@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage nudH GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006281,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009892,GO:0009893,GO:0009894,GO:0009896,GO:0009987,GO:0010468,GO:0010604,GO:0010605,GO:0010608,GO:0010629,GO:0016070,GO:0016071,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0019219,GO:0019222,GO:0019439,GO:0031323,GO:0031325,GO:0031329,GO:0031331,GO:0033554,GO:0034353,GO:0034641,GO:0034655,GO:0043167,GO:0043169,GO:0043170,GO:0043487,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0045935,GO:0046483,GO:0046700,GO:0046872,GO:0048518,GO:0048519,GO:0048522,GO:0050779,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051716,GO:0060255,GO:0065007,GO:0065008,GO:0071704,GO:0080090,GO:0090304,GO:1901360,GO:1901361,GO:1901575 - ko:K08311 ko03018,map03018 - R10816 RC00002 ko00000,ko00001,ko01000,ko03019 - - - NUDIX k59_87819_1 1028800.RG540_CH09640 6.57e-76 242.0 COG0644@1|root,COG0644@2|Bacteria,1QM8G@1224|Proteobacteria,2TV3N@28211|Alphaproteobacteria,4BP0B@82115|Rhizobiaceae 28211|Alphaproteobacteria C Glucose inhibited division protein A - - - - - - - - - - - - FAD_oxidored k59_30688_1 1443665.JACA01000012_gene1222 1.15e-97 292.0 COG0468@1|root,COG0468@2|Bacteria,4NEXT@976|Bacteroidetes,1HY3S@117743|Flavobacteriia,2YHC1@290174|Aquimarina 976|Bacteroidetes L KaiC recA - - ko:K03553 ko03440,map03440 M00729 - - ko00000,ko00001,ko00002,ko03400 - - - RecA k59_1158640_1 686340.Metal_1376 5.01e-09 63.2 COG1109@1|root,COG1109@2|Bacteria,1MUA5@1224|Proteobacteria,1RMU8@1236|Gammaproteobacteria,1XDTR@135618|Methylococcales 135618|Methylococcales G alpha beta alpha domain I - - 5.4.2.2,5.4.2.8 ko:K15778 ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130 M00114 R00959,R01057,R01818,R08639 RC00408 ko00000,ko00001,ko00002,ko01000 - - - PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV k59_1568171_1 521719.ATXQ01000010_gene70 4.96e-52 184.0 COG0657@1|root,COG2072@1|root,COG0657@2|Bacteria,COG2072@2|Bacteria,1MUQH@1224|Proteobacteria,1RPJY@1236|Gammaproteobacteria,1YDZQ@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria P L-lysine 6-monooxygenase (NADPH-requiring) - - - - - - - - - - - - Abhydrolase_3,FMO-like,K_oxygenase,Pyr_redox_3 k59_1568171_2 1122137.AQXF01000003_gene2166 1.71e-28 109.0 COG0834@1|root,COG0834@2|Bacteria,1RH2S@1224|Proteobacteria,2UHC7@28211|Alphaproteobacteria 28211|Alphaproteobacteria ET ABC-type amino acid transport signal transduction systems periplasmic component domain - - - ko:K02030 - M00236 - - ko00000,ko00002,ko02000 3.A.1.3 - - SBP_bac_3 k59_606255_1 158500.BV97_02524 1.22e-66 215.0 29QDR@1|root,30BD1@2|Bacteria,1N2Q2@1224|Proteobacteria,2UDCN@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_380998_1 1545915.JROG01000004_gene2131 2.92e-51 176.0 COG0520@1|root,COG0520@2|Bacteria,1R6VV@1224|Proteobacteria,2VFZ3@28211|Alphaproteobacteria,2K05V@204457|Sphingomonadales 204457|Sphingomonadales E Aminotransferase, class V - - - - - - - - - - - - Aminotran_5 k59_1226385_1 436308.Nmar_0765 6.58e-23 92.0 COG1259@1|root,arCOG01759@2157|Archaea,41SQI@651137|Thaumarchaeota 651137|Thaumarchaeota S Bifunctional nuclease - - - ko:K08999 - - - - ko00000 - - - DNase-RNase k59_1226385_2 1229909.NSED_04700 2.7e-53 169.0 COG0346@1|root,arCOG02708@2157|Archaea,41SU3@651137|Thaumarchaeota 651137|Thaumarchaeota E Glyoxalase-like domain - - 4.4.1.5 ko:K01759 ko00620,map00620 - R02530 RC00004,RC00740 ko00000,ko00001,ko01000 - - - Glyoxalase,Glyoxalase_2 k59_1569135_1 1121106.JQKB01000007_gene1050 3.6e-70 223.0 COG2055@1|root,COG2055@2|Bacteria,1MWQY@1224|Proteobacteria,2TR37@28211|Alphaproteobacteria 28211|Alphaproteobacteria C Belongs to the LDH2 MDH2 oxidoreductase family - - - - - - - - - - - - Ldh_2 k59_433143_1 69042.WH5701_14431 1.25e-10 62.0 COG0424@1|root,COG0424@2|Bacteria,1G59Y@1117|Cyanobacteria,1H081@1129|Synechococcus 1117|Cyanobacteria D Maf-like protein maf - - ko:K06287 - - - - ko00000 - - - Maf k59_433143_2 1128421.JAGA01000003_gene3421 1.6e-46 162.0 COG0325@1|root,COG0325@2|Bacteria,2NPEW@2323|unclassified Bacteria 2|Bacteria S Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis yggS GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0008144,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0044464,GO:0048037,GO:0050662,GO:0070279,GO:0097159,GO:1901363 - ko:K06997 - - - - ko00000 - - - Ala_racemase_N k59_1279887_1 1131553.JIBI01000042_gene2002 2.82e-16 85.1 COG2206@1|root,COG2206@2|Bacteria,1MW7F@1224|Proteobacteria,2WEJB@28216|Betaproteobacteria,37412@32003|Nitrosomonadales 28216|Betaproteobacteria T Domain of unknown function (DUF3391) - - - - - - - - - - - - DUF3391,HD_5 k59_1111355_1 1382356.JQMP01000003_gene1841 3.96e-40 151.0 COG2217@1|root,COG2217@2|Bacteria,2G5J7@200795|Chloroflexi,27Y1J@189775|Thermomicrobia 189775|Thermomicrobia P ATPase, P-type (transporting), HAD superfamily, subfamily IC - - 3.6.3.54 ko:K17686 ko01524,ko04016,map01524,map04016 - R00086 RC00002 ko00000,ko00001,ko01000 3.A.3.5 - - E1-E2_ATPase,HMA,Hydrolase k59_433153_1 247634.GPB2148_2116 2.18e-85 273.0 COG2804@1|root,COG2804@2|Bacteria,1R5CG@1224|Proteobacteria,1RV00@1236|Gammaproteobacteria,1J5MV@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria NU Type II secretion system (T2SS), protein E, N-terminal domain - - - ko:K02652 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - PCMT,T2SSE,T2SSE_N k59_381943_1 1500306.JQLA01000021_gene3098 1.01e-14 76.3 COG2010@1|root,COG2010@2|Bacteria,1MV6D@1224|Proteobacteria,2TVYT@28211|Alphaproteobacteria,4B7QN@82115|Rhizobiaceae 1224|Proteobacteria C Cytochrome C oxidase, cbb3-type, subunit III - - - - - - - - - - - - Cytochrom_C,Cytochrome_CBB3 k59_381943_5 1410613.JNKF01000013_gene2437 1.66e-12 68.9 COG1595@1|root,COG1595@2|Bacteria,4NMC0@976|Bacteroidetes,2FP0F@200643|Bacteroidia 976|Bacteroidetes K Belongs to the sigma-70 factor family. ECF subfamily sigW - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 k59_381943_6 1268237.G114_18096 3.04e-10 64.7 COG2091@1|root,COG2091@2|Bacteria 2|Bacteria H lysine biosynthetic process via aminoadipic acid sfp - 2.7.8.7 ko:K00997,ko:K06133 ko00770,map00770 - R01625 RC00002 ko00000,ko00001,ko01000 - - - ACPS k59_381943_7 1282876.BAOK01000001_gene3525 4.86e-12 67.0 COG0702@1|root,COG0702@2|Bacteria,1RDKF@1224|Proteobacteria,2U7MU@28211|Alphaproteobacteria 28211|Alphaproteobacteria GM NAD-dependent epimerase dehydratase - - - - - - - - - - - - NAD_binding_10 k59_267361_1 243365.CV_3685 7.36e-76 236.0 COG0714@1|root,COG0714@2|Bacteria,1MUFN@1224|Proteobacteria,2VKJJ@28216|Betaproteobacteria,2KQ80@206351|Neisseriales 206351|Neisseriales S ATPase family associated with various cellular activities (AAA) - - - ko:K03924 - - - - ko00000,ko01000 - - - AAA_3 k59_1786530_1 1502852.FG94_00890 5.69e-37 145.0 COG0515@1|root,COG2199@1|root,COG3899@1|root,COG0515@2|Bacteria,COG3706@2|Bacteria,COG3899@2|Bacteria,1R7HC@1224|Proteobacteria,2WGMD@28216|Betaproteobacteria,4791R@75682|Oxalobacteraceae 28216|Betaproteobacteria KLT Protein tyrosine kinase - - - - - - - - - - - - AAA_16,GGDEF,Pkinase k59_1786530_2 211586.SO_0737 1.01e-05 46.6 COG4206@1|root,COG4206@2|Bacteria,1N71E@1224|Proteobacteria,1RPBH@1236|Gammaproteobacteria,2QB3N@267890|Shewanellaceae 1236|Gammaproteobacteria H TonB-dependent receptor - - - - - - - - - - - - HupE_UreJ,Plug,TonB_dep_Rec k59_720313_1 1121403.AUCV01000028_gene2424 5.8e-06 55.8 COG3299@1|root,COG3299@2|Bacteria,1MWKI@1224|Proteobacteria,42MUS@68525|delta/epsilon subdivisions,2WKK4@28221|Deltaproteobacteria,2MP4C@213118|Desulfobacterales 28221|Deltaproteobacteria S homolog of phage Mu protein gp47 - - - - - - - - - - - - - k59_1786537_1 314287.GB2207_00395 1.83e-50 164.0 COG0848@1|root,COG0848@2|Bacteria,1MZ6M@1224|Proteobacteria,1S8RS@1236|Gammaproteobacteria,1J6H1@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria U Biopolymer transport protein tolR GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0015833,GO:0015893,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0032153,GO:0042221,GO:0042493,GO:0042886,GO:0042891,GO:0043213,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944 - ko:K03560 - - - - ko00000,ko02000 1.A.30.2.2 - - ExbD k59_1786537_2 1056820.KB900643_gene804 3.23e-08 55.5 COG0810@1|root,COG0810@2|Bacteria,1RKRA@1224|Proteobacteria,1SWSP@1236|Gammaproteobacteria,2PNN3@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria M TonB C terminal - - - ko:K03646 - - - - ko00000,ko02000 2.C.1.2 - - TonB_2 k59_1398712_1 1088721.NSU_2325 2.29e-34 133.0 COG2271@1|root,COG2271@2|Bacteria,1P3P1@1224|Proteobacteria,2TVM7@28211|Alphaproteobacteria,2K00U@204457|Sphingomonadales 204457|Sphingomonadales G Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 k59_771214_1 247634.GPB2148_1820 4.78e-112 336.0 COG0029@1|root,COG0029@2|Bacteria,1RBQW@1224|Proteobacteria,1RMMD@1236|Gammaproteobacteria,1J59P@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Catalyzes the oxidation of L-aspartate to iminoaspartate nadB GO:0000166,GO:0001716,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006734,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008734,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0015922,GO:0016491,GO:0016638,GO:0016641,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044318,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046496,GO:0048037,GO:0050660,GO:0050662,GO:0051186,GO:0051188,GO:0055086,GO:0055114,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605 1.4.3.16 ko:K00278 ko00250,ko00760,ko01100,map00250,map00760,map01100 M00115 R00357,R00481 RC00006,RC02566 ko00000,ko00001,ko00002,ko01000 - - iAF1260.b2574,iBWG_1329.BWG_2338,iECDH10B_1368.ECDH10B_2742,iECDH1ME8569_1439.ECDH1ME8569_2501,iETEC_1333.ETEC_2787,iEcDH1_1363.EcDH1_1094,iJO1366.b2574,iJR904.b2574,iLF82_1304.LF82_1433,iNRG857_1313.NRG857_12785,iY75_1357.Y75_RS13445,iYL1228.KPN_02899 FAD_binding_2,Succ_DH_flav_C k59_1786546_1 1229909.NSED_09265 8.14e-57 188.0 arCOG08768@1|root,arCOG08768@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_607221_1 428125.CLOLEP_00359 1.13e-08 55.8 COG0816@1|root,COG0816@2|Bacteria,1V6ER@1239|Firmicutes,24JGP@186801|Clostridia,3WJ8E@541000|Ruminococcaceae 186801|Clostridia L Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA yrrK - - ko:K07447 - - - - ko00000,ko01000 - - - RuvX k59_267378_2 1279017.AQYJ01000024_gene869 6.8e-28 111.0 COG0598@1|root,COG0598@2|Bacteria,1MWMP@1224|Proteobacteria,1RNDQ@1236|Gammaproteobacteria 1236|Gammaproteobacteria P Mediates influx of magnesium ions - - - - - - - - - - - - CorA k59_659335_2 330214.NIDE0608 8.17e-94 282.0 COG1005@1|root,COG1005@2|Bacteria,3J0E2@40117|Nitrospirae 40117|Nitrospirae C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone nuoH - 1.6.5.3 ko:K00337 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - NADHdh k59_1511520_1 795666.MW7_3155 8.51e-80 259.0 COG0280@1|root,COG0281@1|root,COG0280@2|Bacteria,COG0281@2|Bacteria,1MU0A@1224|Proteobacteria,2VIYB@28216|Betaproteobacteria,1K2P6@119060|Burkholderiaceae 28216|Betaproteobacteria C Malic enzyme maeB - 1.1.1.40 ko:K00029 ko00620,ko00710,ko01100,ko01120,ko01200,map00620,map00710,map01100,map01120,map01200 M00169,M00172 R00216 RC00105 ko00000,ko00001,ko00002,ko01000 - - - Malate_DH,Malic_M,PTA_PTB,malic k59_941491_1 998088.B565_1590 7.41e-26 110.0 COG1807@1|root,COG1807@2|Bacteria,1REWS@1224|Proteobacteria,1S4QV@1236|Gammaproteobacteria 1236|Gammaproteobacteria M 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family - - - - - - - - - - - - - k59_941491_2 558884.JRGM01000144_gene1557 3.43e-37 135.0 COG0497@1|root,COG0497@2|Bacteria,1RK1H@1224|Proteobacteria,1S734@1236|Gammaproteobacteria 1236|Gammaproteobacteria L DNA recombination - - - - - - - - - - - - - k59_1398740_1 1122137.AQXF01000001_gene3109 7.69e-70 216.0 COG5342@1|root,COG5342@2|Bacteria,1R46Z@1224|Proteobacteria,2U5KW@28211|Alphaproteobacteria 28211|Alphaproteobacteria S invasion associated locus B - - - - - - - - - - - - - k59_1398740_2 1122137.AQXF01000001_gene3110 3.4e-89 266.0 COG0566@1|root,COG0566@2|Bacteria,1REIN@1224|Proteobacteria,2U76Y@28211|Alphaproteobacteria 28211|Alphaproteobacteria J rrna methyltransferase - - - - - - - - - - - - SpoU_methylase k59_1398740_3 1122137.AQXF01000001_gene3111 3.53e-29 114.0 COG2271@1|root,COG2271@2|Bacteria,1QV8S@1224|Proteobacteria,2TZ56@28211|Alphaproteobacteria 28211|Alphaproteobacteria G Transmembrane secretion effector - - - - - - - - - - - - MFS_3 k59_771244_2 883109.HMPREF0380_00829 1.59e-42 152.0 COG0351@1|root,COG0351@2|Bacteria,1TQ4A@1239|Firmicutes,2483H@186801|Clostridia,3WCGZ@538999|Clostridiales incertae sedis 186801|Clostridia H Phosphomethylpyrimidine kinase thiD - 2.7.1.49,2.7.4.7 ko:K00941 ko00730,ko01100,map00730,map01100 M00127 R03471,R04509 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - Phos_pyr_kin k59_382004_1 498211.CJA_1269 7.54e-96 292.0 COG1066@1|root,COG1066@2|Bacteria,1MUJQ@1224|Proteobacteria,1RN2E@1236|Gammaproteobacteria,1FGR5@10|Cellvibrio 1236|Gammaproteobacteria O DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function radA GO:0000725,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009314,GO:0009628,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363 - ko:K04485 - - - - ko00000,ko03400 - - - AAA_25,ATPase,ChlI k59_1569214_1 1397527.Q670_05425 1.62e-22 101.0 COG3170@1|root,COG3170@2|Bacteria,1MXV7@1224|Proteobacteria,1RMM5@1236|Gammaproteobacteria,1XIW5@135619|Oceanospirillales 135619|Oceanospirillales NU Tfp pilus assembly protein - - - ko:K08086 - - - - ko00000 - - - LysM,TPR_19 k59_1336547_1 1469557.JSWF01000028_gene2839 9.19e-53 171.0 COG4319@1|root,COG4319@2|Bacteria,4NNSF@976|Bacteroidetes,1I234@117743|Flavobacteriia 976|Bacteroidetes S SnoaL-like domain - - - - - - - - - - - - SnoaL_3 k59_1336547_2 1380600.AUYN01000006_gene689 1.01e-16 76.6 2E0H2@1|root,32W2Y@2|Bacteria,4NT2B@976|Bacteroidetes 976|Bacteroidetes - - - - - - - - - - - - - - - k59_209872_1 393283.XP_007832291.1 3.67e-11 67.0 COG1252@1|root,KOG2495@2759|Eukaryota,38G4F@33154|Opisthokonta,3NVY5@4751|Fungi,3QJRT@4890|Ascomycota,2157G@147550|Sordariomycetes 4751|Fungi C nadh dehydrogenase - - 1.6.99.3 ko:K03885 ko00190,map00190 - - - ko00000,ko00001,ko01000 - - - EF-hand_1,EF-hand_5,Pyr_redox_2 k59_830148_1 1121423.JONT01000011_gene237 6.72e-36 134.0 COG1307@1|root,COG1307@2|Bacteria,1TQDI@1239|Firmicutes,24ADT@186801|Clostridia,261D5@186807|Peptococcaceae 186801|Clostridia S PFAM Uncharacterised protein, DegV family COG1307 - - - - - - - - - - - - DegV k59_544076_1 640081.Dsui_1394 1.64e-34 130.0 COG3063@1|root,COG3063@2|Bacteria,1R1AG@1224|Proteobacteria,2WI0F@28216|Betaproteobacteria,2KZXT@206389|Rhodocyclales 206389|Rhodocyclales NU Tetratricopeptide repeat - - - - - - - - - - - - - k59_1450094_1 292414.TM1040_3007 6.08e-88 273.0 COG2987@1|root,COG2987@2|Bacteria,1MU4W@1224|Proteobacteria,2TSJR@28211|Alphaproteobacteria,4NA67@97050|Ruegeria 28211|Alphaproteobacteria H Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate hutU - 4.2.1.49 ko:K01712 ko00340,ko01100,map00340,map01100 M00045 R02914 RC00804 ko00000,ko00001,ko00002,ko01000 - - - Urocanase,Urocanase_C,Urocanase_N k59_1450094_2 1301098.PKB_5395 5.74e-63 210.0 COG2986@1|root,COG2986@2|Bacteria,1MU6K@1224|Proteobacteria,1RP02@1236|Gammaproteobacteria 1236|Gammaproteobacteria E histidine ammonia-lyase hutH GO:0003674,GO:0003824,GO:0004397,GO:0006082,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016829,GO:0016840,GO:0016841,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0071704,GO:1901564 4.3.1.3 ko:K01745 ko00340,ko01100,map00340,map01100 M00045 R01168 RC00361 ko00000,ko00001,ko00002,ko01000 - - - Lyase_aromatic k59_1450095_1 1121918.ARWE01000001_gene953 0.00082 40.8 COG4726@1|root,COG4726@2|Bacteria,1PQMG@1224|Proteobacteria,430ZZ@68525|delta/epsilon subdivisions,2WWZF@28221|Deltaproteobacteria,43VI0@69541|Desulfuromonadales 28221|Deltaproteobacteria NU Pilus assembly protein PilX - - - ko:K12286 - - - - ko00000,ko02044 - - - - k59_1450095_2 338963.Pcar_0394 3.21e-29 115.0 COG2165@1|root,COG2165@2|Bacteria,1RK34@1224|Proteobacteria,42Y1S@68525|delta/epsilon subdivisions,2WTH8@28221|Deltaproteobacteria,43U7J@69541|Desulfuromonadales 28221|Deltaproteobacteria NU Prokaryotic N-terminal methylation motif - - - ko:K12285 - - - - ko00000,ko02044 - - - N_methyl k59_1511549_1 1122612.AUBA01000002_gene1876 9.68e-115 354.0 COG4773@1|root,COG4773@2|Bacteria,1NXPR@1224|Proteobacteria,2U161@28211|Alphaproteobacteria 28211|Alphaproteobacteria P TonB-dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_830165_1 1167006.UWK_02574 2.59e-20 84.3 COG1327@1|root,COG1327@2|Bacteria,1RE7V@1224|Proteobacteria,42SJP@68525|delta/epsilon subdivisions,2WPK0@28221|Deltaproteobacteria,2MJT3@213118|Desulfobacterales 28221|Deltaproteobacteria K Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes nrdR - - ko:K07738 - - - - ko00000,ko03000 - - - ATP-cone k59_830165_2 589865.DaAHT2_1281 3.12e-56 178.0 COG2131@1|root,COG2131@2|Bacteria,1RD1P@1224|Proteobacteria,42RHI@68525|delta/epsilon subdivisions,2WNGV@28221|Deltaproteobacteria,2MJGN@213118|Desulfobacterales 28221|Deltaproteobacteria F PFAM CMP dCMP deaminase zinc-binding comEB - 3.5.4.12 ko:K01493 ko00240,ko01100,map00240,map01100 M00429 R01663 RC00074 ko00000,ko00001,ko00002,ko01000,ko02044 - - - dCMP_cyt_deam_1 k59_267411_1 1122137.AQXF01000003_gene2417 2.22e-110 337.0 COG2234@1|root,COG2234@2|Bacteria,1NVWC@1224|Proteobacteria 1224|Proteobacteria S Peptidase family M28 - - - - - - - - - - - - Peptidase_M28 k59_890470_1 926569.ANT_04650 3.78e-128 380.0 COG0031@1|root,COG0031@2|Bacteria,2G8GE@200795|Chloroflexi 200795|Chloroflexi E Pyridoxal-phosphate dependent enzyme - - - - - - - - - - - - PALP k59_98113_1 1502851.FG93_01521 2.24e-45 166.0 COG0845@1|root,COG0845@2|Bacteria,1MU8D@1224|Proteobacteria,2U139@28211|Alphaproteobacteria,3JUSS@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria M Barrel-sandwich domain of CusB or HlyD membrane-fusion - - - ko:K02005,ko:K13888 - M00709 - - ko00000,ko00002,ko02000 8.A.1 - - Biotin_lipoyl_2,HlyD_D23 k59_544119_1 1206730.BAGA01000171_gene2202 6.02e-55 189.0 COG0318@1|root,COG0318@2|Bacteria,2IEKP@201174|Actinobacteria,4FUBQ@85025|Nocardiaceae 201174|Actinobacteria IQ AMP-binding enzyme C-terminal domain - - - - - - - - - - - - AMP-binding,AMP-binding_C k59_771301_1 1380600.AUYN01000001_gene2251 4.1e-13 68.6 COG1044@1|root,COG1044@2|Bacteria,4NFXA@976|Bacteroidetes,1HXWG@117743|Flavobacteriia 976|Bacteroidetes M glucosamine N-acyltransferase lpxD1 - 2.3.1.191 ko:K02536 ko00540,ko01100,map00540,map01100 M00060 R04550 RC00039,RC00166 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Hexapep,Hexapep_2,LpxD k59_771301_2 946077.W5A_11921 7.76e-73 225.0 COG0074@1|root,COG0074@2|Bacteria,4NE6B@976|Bacteroidetes,1HX04@117743|Flavobacteriia 976|Bacteroidetes C Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit sucD - 6.2.1.5 ko:K01902 ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374,M00620 R00405,R02404 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000 - - - CoA_binding,Ligase_CoA,Succ_CoA_lig k59_941539_1 1096930.L284_18095 5.52e-125 358.0 COG0740@1|root,COG0740@2|Bacteria,1MV46@1224|Proteobacteria,2TR5M@28211|Alphaproteobacteria,2JZX6@204457|Sphingomonadales 204457|Sphingomonadales OU Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins clpP - 3.4.21.92 ko:K01358 ko04112,ko04212,map04112,map04212 - - - ko00000,ko00001,ko01000,ko01002 - - - CLP_protease k59_209927_1 1122137.AQXF01000003_gene1994 9.34e-100 303.0 COG1012@1|root,COG1012@2|Bacteria,1MUHV@1224|Proteobacteria,2TSMD@28211|Alphaproteobacteria 28211|Alphaproteobacteria C Methylmalonate-semialdehyde dehydrogenase mmsA GO:0003674,GO:0005488,GO:0005507,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0006950,GO:0006979,GO:0008150,GO:0043167,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0050896 1.2.1.18,1.2.1.27 ko:K00140 ko00280,ko00410,ko00562,ko00640,ko01100,ko01200,map00280,map00410,map00562,map00640,map01100,map01200 M00013 R00705,R00706,R00922,R00935 RC00004,RC02723,RC02817 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_997161_1 85643.Tmz1t_4034 4.95e-102 312.0 COG1021@1|root,COG1021@2|Bacteria,1NSN8@1224|Proteobacteria,2WGU9@28216|Betaproteobacteria 28216|Betaproteobacteria Q AMP-binding enzyme C-terminal domain - - - - - - - - - - - - AMP-binding,AMP-binding_C k59_1336587_1 1121861.KB899918_gene3287 8.54e-49 166.0 COG1694@1|root,COG3956@2|Bacteria,1MVKM@1224|Proteobacteria,2TRC9@28211|Alphaproteobacteria,2JPGN@204441|Rhodospirillales 204441|Rhodospirillales S MazG nucleotide pyrophosphohydrolase domain mazG - 3.6.1.9 ko:K04765 ko00230,ko00240,ko00760,ko00770,ko01100,map00230,map00240,map00760,map00770,map01100 - R00086,R00087,R00103,R00287,R00426,R00515,R00662,R00720,R03004,R03036,R11323 RC00002 ko00000,ko00001,ko01000 - - - MazG k59_997168_1 756067.MicvaDRAFT_1934 2.08e-13 75.5 COG2114@1|root,COG2202@1|root,COG3437@1|root,COG2114@2|Bacteria,COG2202@2|Bacteria,COG3437@2|Bacteria,1GQRR@1117|Cyanobacteria,1H9GQ@1150|Oscillatoriales 1117|Cyanobacteria T PFAM Adenylate and Guanylate cyclase catalytic domain - - 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 - - - Guanylate_cyc,PAS_9,Response_reg k59_890500_1 436308.Nmar_0409 7.31e-93 283.0 COG0579@1|root,arCOG00754@2157|Archaea,41SXA@651137|Thaumarchaeota 651137|Thaumarchaeota S FAD dependent oxidoreductase - - - ko:K15736 - - - - ko00000,ko01000 - - - DAO k59_890500_2 1229909.NSED_02130 7.8e-36 123.0 arCOG08666@1|root,arCOG08666@2157|Archaea,41SVR@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_42379_1 436308.Nmar_0567 5.31e-37 132.0 arCOG11722@1|root,arCOG11722@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_1621922_1 1229909.NSED_08535 1.78e-37 136.0 arCOG07810@1|root,arCOG07810@2157|Archaea,41T4X@651137|Thaumarchaeota 651137|Thaumarchaeota T COG2114 Adenylate cyclase, family 3 (some proteins contain HAMP domain) - - 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 - - - Guanylate_cyc k59_1226541_1 1280380.KR100_04630 6.97e-10 63.9 COG0843@1|root,COG0843@2|Bacteria,1G1ME@1117|Cyanobacteria,1GZH3@1129|Synechococcus 1117|Cyanobacteria C Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B cyoB - 1.9.3.1 ko:K02274 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6 - - COX1 k59_1226541_2 644966.Tmar_1595 1.11e-17 81.3 COG1622@1|root,COG1622@2|Bacteria,1TRC3@1239|Firmicutes,25348@186801|Clostridia 186801|Clostridia C Cytochrome C oxidase subunit II, periplasmic domain - - 1.9.3.1 ko:K02275 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.4,3.D.4.6 - - COX2 k59_152358_1 1333998.M2A_2835 2.09e-128 379.0 COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2TQR1@28211|Alphaproteobacteria 28211|Alphaproteobacteria C belongs to the aldehyde dehydrogenase family - GO:0001505,GO:0003674,GO:0003824,GO:0004777,GO:0006082,GO:0006520,GO:0006525,GO:0006527,GO:0006576,GO:0006595,GO:0006598,GO:0006807,GO:0008150,GO:0008152,GO:0009013,GO:0009056,GO:0009063,GO:0009064,GO:0009065,GO:0009308,GO:0009310,GO:0009445,GO:0009447,GO:0009448,GO:0009450,GO:0009987,GO:0016054,GO:0016491,GO:0016620,GO:0016903,GO:0019752,GO:0032787,GO:0034641,GO:0042133,GO:0042135,GO:0042402,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0055114,GO:0065007,GO:0065008,GO:0071704,GO:0072329,GO:0097164,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 1.2.1.16,1.2.1.20,1.2.1.24,1.2.1.79 ko:K00135,ko:K08324 ko00250,ko00310,ko00350,ko00650,ko00760,ko01100,ko01120,map00250,map00310,map00350,map00650,map00760,map01100,map01120 M00027 R00713,R00714,R02401 RC00080 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_42385_1 1333998.M2A_2027 2.79e-78 241.0 COG2267@1|root,COG2267@2|Bacteria,1QTAP@1224|Proteobacteria,2TU8W@28211|Alphaproteobacteria,4BT6G@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria I Alpha/beta hydrolase family - - - - - - - - - - - - Abhydrolase_1,Abhydrolase_6 k59_659456_2 1453501.JELR01000001_gene2396 5.48e-21 94.4 COG3975@1|root,COG3975@2|Bacteria,1QX25@1224|Proteobacteria,1RWD8@1236|Gammaproteobacteria,466PD@72275|Alteromonadaceae 1236|Gammaproteobacteria S protease with the C-terminal PDZ domain - - - - - - - - - - - - - k59_1226543_1 1094980.Mpsy_2537 1.02e-81 253.0 COG0668@1|root,arCOG01569@2157|Archaea,2XVK0@28890|Euryarchaeota,2N9S8@224756|Methanomicrobia 224756|Methanomicrobia M MscS Mechanosensitive ion channel - - - - - - - - - - - - MS_channel k59_1226544_1 247633.GP2143_02314 1.02e-37 137.0 COG0008@1|root,COG0008@2|Bacteria,1MUCR@1224|Proteobacteria,1RN3R@1236|Gammaproteobacteria,1J547@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) gltX GO:0003674,GO:0003824,GO:0004812,GO:0004818,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006424,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.17 ko:K01885 ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120 M00121,M00359,M00360 R05578 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016 - - iEC042_1314.EC042_2616 tRNA-synt_1c k59_1226544_2 283699.D172_0924 1.82e-19 93.2 COG5001@1|root,COG5001@2|Bacteria,1PV95@1224|Proteobacteria,1RRN3@1236|Gammaproteobacteria,2PZZB@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria T signal transduction protein containing a membrane domain, an EAL and a GGDEF domain - - - - - - - - - - - - 7TMR-DISMED2,7TMR-DISM_7TM,EAL,GGDEF k59_1569304_1 1229909.NSED_07790 1.03e-132 379.0 arCOG08773@1|root,arCOG08773@2157|Archaea,41SNY@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1569304_2 1229909.NSED_07785 9.04e-09 55.1 COG0284@1|root,arCOG00081@2157|Archaea,41SMN@651137|Thaumarchaeota 651137|Thaumarchaeota F Orotidine 5'-phosphate decarboxylase / HUMPS family - - 4.1.1.23 ko:K01591 ko00240,ko01100,map00240,map01100 M00051 R00965 RC00409 ko00000,ko00001,ko00002,ko01000 - - - OMPdecase k59_720461_1 1229909.NSED_04725 4.52e-34 121.0 COG2096@1|root,arCOG00489@2157|Archaea,41T2I@651137|Thaumarchaeota 651137|Thaumarchaeota H Cobalamin adenosyltransferase - - 2.5.1.17 ko:K00798 ko00860,ko01100,map00860,map01100 M00122 R01492,R05220,R07268 RC00533 ko00000,ko00001,ko00002,ko01000 - - - Cob_adeno_trans k59_720461_2 1229909.NSED_04730 6.81e-60 192.0 COG1896@1|root,arCOG04311@2157|Archaea,41SQE@651137|Thaumarchaeota 651137|Thaumarchaeota S HD domain - - - ko:K07023 - - - - ko00000 - - - HD_3 k59_720461_3 436308.Nmar_0860 5.25e-26 97.8 arCOG10554@1|root,arCOG10554@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_720461_4 1229909.NSED_04740 4.76e-33 117.0 arCOG10555@1|root,arCOG10555@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_720461_5 1229909.NSED_04745 6.96e-51 162.0 arCOG08655@1|root,arCOG08655@2157|Archaea,41SR9@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1786687_2 436308.Nmar_1589 2.84e-25 95.5 arCOG10591@1|root,arCOG10591@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_720468_1 203124.Tery_4975 3.6e-13 71.6 COG3415@1|root,COG3415@2|Bacteria,1G0GB@1117|Cyanobacteria,1H89N@1150|Oscillatoriales 1117|Cyanobacteria L Winged helix-turn helix - - - - - - - - - - - - DDE_3,HTH_23,HTH_32,HTH_33 k59_720468_2 1279015.KB908455_gene1292 1.83e-08 56.6 COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,1MW7X@1224|Proteobacteria,1RRF4@1236|Gammaproteobacteria,1Y3VF@135624|Aeromonadales 135624|Aeromonadales L DDE superfamily endonuclease - - - - - - - - - - - - DDE_3,HTH_23,HTH_32,HTH_33 k59_721507_2 1122137.AQXF01000003_gene2276 5.15e-29 109.0 COG5456@1|root,COG5456@2|Bacteria 2|Bacteria P FixH fixH - - - - - - - - - - - FixH k59_1459490_2 1116375.VEJY3_10045 8.69e-07 49.7 COG1846@1|root,COG1846@2|Bacteria,1RF8X@1224|Proteobacteria,1S4RW@1236|Gammaproteobacteria,1XX10@135623|Vibrionales 135623|Vibrionales K COG1846 Transcriptional regulators - - - - - - - - - - - - MarR k59_277040_1 1158292.JPOE01000005_gene596 7.91e-37 144.0 COG0550@1|root,COG0550@2|Bacteria,1MUFZ@1224|Proteobacteria,2VHUF@28216|Betaproteobacteria,1KJ17@119065|unclassified Burkholderiales 28216|Betaproteobacteria L DNA topoisomerase III topB - 5.99.1.2 ko:K03169 - - - - ko00000,ko01000,ko03032 - - - SWIB,Topoisom_bac,Toprim,Toprim_Crpt k59_218988_1 497964.CfE428DRAFT_2599 2.1e-63 209.0 COG2204@1|root,COG2204@2|Bacteria,46SDB@74201|Verrucomicrobia 74201|Verrucomicrobia T sigma-54 factor interaction domain-containing protein - - - ko:K07712 ko02020,map02020 M00497 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_442686_1 43151.ADAC007681-PA 5.03e-11 64.7 COG1028@1|root,KOG1200@2759|Eukaryota,39S00@33154|Opisthokonta,3BGVB@33208|Metazoa,3CXFR@33213|Bilateria,41YDY@6656|Arthropoda,3SHD5@50557|Insecta,44XHI@7147|Diptera,45CZ8@7148|Nematocera 33208|Metazoa Q Enoyl-(Acyl carrier protein) reductase - - 1.1.1.239,1.1.1.62 ko:K13370 ko00140,ko01100,map00140,map01100 - R01836,R02352,R02353,R04681,R04682,R08945,R08980 RC00127,RC00261 ko00000,ko00001,ko01000 - - - adh_short_C2 k59_442686_2 1122604.JONR01000026_gene2997 2.21e-13 68.2 COG3545@1|root,COG3545@2|Bacteria,1RDB7@1224|Proteobacteria,1S12R@1236|Gammaproteobacteria,1X7UH@135614|Xanthomonadales 135614|Xanthomonadales S Serine hydrolase - - - - - - - - - - - - Ser_hydrolase k59_1289872_1 436308.Nmar_1316 4.28e-150 431.0 COG0477@1|root,arCOG00130@2157|Archaea,41T0X@651137|Thaumarchaeota 651137|Thaumarchaeota G major facilitator superfamily - - - ko:K08153,ko:K08221 - M00717 - - ko00000,ko00002,ko02000 2.A.1.2.8,2.A.1.32 - - MFS_1 k59_1289872_2 436308.Nmar_1318 3.51e-41 139.0 COG1826@1|root,arCOG02694@2157|Archaea,41SRR@651137|Thaumarchaeota 651137|Thaumarchaeota U mttA/Hcf106 family - - - ko:K03116 ko03060,ko03070,map03060,map03070 M00336 - - ko00000,ko00001,ko00002,ko02044 2.A.64 - - MttA_Hcf106 k59_780181_1 257310.BB1573 1.88e-75 241.0 COG4799@1|root,COG4799@2|Bacteria,1MVAX@1224|Proteobacteria,2VIYF@28216|Betaproteobacteria,3T1XI@506|Alcaligenaceae 28216|Betaproteobacteria I Carboxyl transferase domain pccB - 2.1.3.15,6.4.1.3 ko:K01966 ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200 M00373,M00741 R01859 RC00097,RC00609 ko00000,ko00001,ko00002,ko01000 - - - Carboxyl_trans k59_1631308_1 1120998.AUFC01000050_gene3039 8.67e-08 58.9 COG2199@1|root,COG3706@2|Bacteria,1UVRW@1239|Firmicutes,24JVK@186801|Clostridia 186801|Clostridia T Diguanylate cyclase - - - - - - - - - - - - GGDEF,HisKA_7TM,PAS,PAS_4,PAS_8 k59_442690_1 383372.Rcas_3465 2.01e-79 251.0 COG3385@1|root,COG3385@2|Bacteria,2G80K@200795|Chloroflexi 200795|Chloroflexi L sptr a7nhu5 - - - - - - - - - - - - DDE_5 k59_391819_1 1229909.NSED_06150 1.42e-66 205.0 COG1430@1|root,arCOG03116@2157|Archaea,41SP3@651137|Thaumarchaeota 651137|Thaumarchaeota S Uncharacterized ACR, COG1430 - - - ko:K09005 - - - - ko00000 - - - DUF192 k59_839757_1 1122179.KB890436_gene1444 1.17e-13 73.6 COG1975@1|root,COG1975@2|Bacteria,4NG02@976|Bacteroidetes,1IQT3@117747|Sphingobacteriia 976|Bacteroidetes O COGs COG1975 Xanthine and CO dehydrogenase maturation factor XdhC CoxF family xdhC - - ko:K07402 - - - - ko00000 - - - XdhC_C,XdhC_CoxI k59_839757_2 1122201.AUAZ01000003_gene1999 2.85e-73 234.0 COG0665@1|root,COG0665@2|Bacteria,1MVGP@1224|Proteobacteria,1RNJ9@1236|Gammaproteobacteria,464Z5@72275|Alteromonadaceae 1236|Gammaproteobacteria E COG0665 Glycine D-amino acid oxidases (deaminating) ordL GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0016491,GO:0044424,GO:0044464,GO:0055114 - ko:K09471 ko00330,ko01100,map00330,map01100 M00136 R07415 RC00062 ko00000,ko00001,ko00002,ko01000 - - - DAO k59_391831_3 56780.SYN_00866 2.97e-46 157.0 COG2930@1|root,COG2930@2|Bacteria,1RAIB@1224|Proteobacteria,42S9D@68525|delta/epsilon subdivisions,2WN8Y@28221|Deltaproteobacteria,2MQJ7@213462|Syntrophobacterales 28221|Deltaproteobacteria S Las17-binding protein actin regulator - - - - - - - - - - - - Ysc84 k59_1179439_1 565045.NOR51B_1560 1.56e-43 145.0 2DN6U@1|root,32VVA@2|Bacteria,1N6AG@1224|Proteobacteria,1SQ0M@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Cysteine rich repeat - - - - - - - - - - - - Cys_rich_FGFR k59_1743547_1 1121007.AUML01000014_gene2856 8.52e-127 379.0 COG4263@1|root,COG4263@2|Bacteria,4NFNE@976|Bacteroidetes,1HYUT@117743|Flavobacteriia,2YHS1@290174|Aquimarina 976|Bacteroidetes C Nitrous oxide reductase nosZ - 1.7.2.4 ko:K00376 ko00910,ko01120,map00910,map01120 M00529 R02804 RC02861 ko00000,ko00001,ko00002,ko01000 - - - - k59_1743548_1 1121374.KB891575_gene1258 6.01e-75 238.0 COG0334@1|root,COG0334@2|Bacteria,1MUMF@1224|Proteobacteria,1RPUZ@1236|Gammaproteobacteria 1236|Gammaproteobacteria E Belongs to the Glu Leu Phe Val dehydrogenases family gdhA GO:0003674,GO:0003824,GO:0004353,GO:0004354,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016491,GO:0016638,GO:0016639,GO:0019752,GO:0042802,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.4.1.4 ko:K00262 ko00220,ko00250,ko00910,ko01100,map00220,map00250,map00910,map01100 - R00248 RC00006,RC02799 ko00000,ko00001,ko01000 - - iECH74115_1262.ECH74115_2481,iECSP_1301.ECSP_2329,iECs_1301.ECs2467,iG2583_1286.G2583_2207,iPC815.YPO3971,iSDY_1059.SDY_1514,iYL1228.KPN_01210,iZ_1308.Z2793 ELFV_dehydrog,ELFV_dehydrog_N k59_900068_1 158500.BV97_03272 6.01e-102 310.0 COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2TQR1@28211|Alphaproteobacteria,2JZVD@204457|Sphingomonadales 204457|Sphingomonadales C belongs to the aldehyde dehydrogenase family - - 1.2.1.3 ko:K00128 ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130 M00135 R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146 RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_498005_1 247634.GPB2148_1928 2.14e-08 54.7 COG1522@1|root,COG1522@2|Bacteria,1RDB3@1224|Proteobacteria,1S2E1@1236|Gammaproteobacteria 1236|Gammaproteobacteria K transcriptional regulator grp - - ko:K05800 - - - - ko00000,ko03000 - - - AsnC_trans_reg,HTH_24,HTH_AsnC-type k59_498005_2 883126.HMPREF9710_04746 5.24e-143 411.0 COG3185@1|root,COG3185@2|Bacteria,1MUVZ@1224|Proteobacteria,2VJCK@28216|Betaproteobacteria,473X0@75682|Oxalobacteraceae 28216|Betaproteobacteria E Hydroxyphenylpyruvate dioxygenase, HPPD, N-terminal hppD - 1.13.11.27 ko:K00457 ko00130,ko00350,ko00360,ko01100,map00130,map00350,map00360,map01100 M00044 R01372,R02521 RC00505,RC00738 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Glyoxalase,Glyoxalase_5 k59_1179458_2 1033991.RLEG12_30090 2.93e-74 236.0 2BVU5@1|root,2Z9FH@2|Bacteria,1R6RV@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_1179458_3 981383.AEWH01000018_gene3244 1.69e-18 94.7 COG0104@1|root,COG0104@2|Bacteria,1TQ4C@1239|Firmicutes,4H9YT@91061|Bacilli 91061|Bacilli F Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP purA GO:0003674,GO:0003824,GO:0004019,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046033,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.4.4 ko:K01939 ko00230,ko00250,ko01100,map00230,map00250,map01100 M00049 R01135 RC00458,RC00459 ko00000,ko00001,ko00002,ko01000 - - - Adenylsucc_synt k59_1179458_5 497965.Cyan7822_3833 1.16e-49 187.0 COG0210@1|root,COG0210@2|Bacteria,1GQP4@1117|Cyanobacteria 1117|Cyanobacteria L PFAM UvrD REP helicase - - - - - - - - - - - - UvrD-helicase,UvrD_C k59_1179458_8 204669.Acid345_4618 0.000874 46.2 COG0323@1|root,COG0323@2|Bacteria 2|Bacteria L This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex - - - - - - - - - - - - HATPase_c_3 k59_161911_2 298653.Franean1_1405 9.46e-40 138.0 2F2V6@1|root,33VR3@2|Bacteria,2HTY2@201174|Actinobacteria,4EVFE@85013|Frankiales 201174|Actinobacteria - - - - - - - - - - - - - - - k59_1686633_1 113395.AXAI01000002_gene5153 7.33e-19 85.9 COG0843@1|root,COG0843@2|Bacteria,1MU7S@1224|Proteobacteria,2TRBG@28211|Alphaproteobacteria,3JUJQ@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria C Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B coxN GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015672,GO:0015980,GO:0015988,GO:0015990,GO:0016020,GO:0022900,GO:0022904,GO:0034220,GO:0044237,GO:0044464,GO:0045333,GO:0051179,GO:0051234,GO:0055085,GO:0055114,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:1902600 1.9.3.1 ko:K02274 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6 - - COX1 k59_1686633_2 382464.ABSI01000010_gene3667 6.83e-27 104.0 COG1845@1|root,COG1845@2|Bacteria,46SRD@74201|Verrucomicrobia,2IU4E@203494|Verrucomicrobiae 203494|Verrucomicrobiae C Cytochrome c oxidase subunit III - - - - - - - - - - - - COX3 k59_1520963_1 1123270.ATUR01000006_gene172 3.24e-42 145.0 COG1028@1|root,COG1028@2|Bacteria,1R942@1224|Proteobacteria,2U1U1@28211|Alphaproteobacteria,2K0XC@204457|Sphingomonadales 204457|Sphingomonadales IQ Enoyl-(Acyl carrier protein) reductase - - - - - - - - - - - - adh_short_C2 k59_1520963_2 1144305.PMI02_03416 1.09e-31 120.0 COG1804@1|root,COG1804@2|Bacteria,1MWPB@1224|Proteobacteria,2U1YE@28211|Alphaproteobacteria,2K3RY@204457|Sphingomonadales 204457|Sphingomonadales C acyl-CoA transferase carnitine dehydratase - - - - - - - - - - - - CoA_transf_3 k59_107460_1 530564.Psta_4267 8.04e-33 134.0 COG0004@1|root,COG0642@1|root,COG0784@1|root,COG0004@2|Bacteria,COG0784@2|Bacteria,COG2205@2|Bacteria,2IX1S@203682|Planctomycetes 203682|Planctomycetes T Histidine kinase - - - - - - - - - - - - Ammonium_transp,HAMP,HATPase_c,HisKA,Hpt,Response_reg k59_1120584_1 7719.XP_002122687.1 4.42e-18 88.2 COG2084@1|root,KOG1904@1|root,KOG0409@2759|Eukaryota,KOG1904@2759|Eukaryota,38N1F@33154|Opisthokonta,3BDE6@33208|Metazoa,3CXD6@33213|Bilateria,481D3@7711|Chordata 33208|Metazoa K phosphogluconate dehydrogenase (decarboxylating) activity GLYR1 GO:0000785,GO:0000786,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005694,GO:0005700,GO:0005705,GO:0005737,GO:0005794,GO:0005829,GO:0012505,GO:0016604,GO:0016607,GO:0031974,GO:0031981,GO:0032991,GO:0032993,GO:0035064,GO:0042393,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0044422,GO:0044424,GO:0044427,GO:0044428,GO:0044444,GO:0044446,GO:0044451,GO:0044464,GO:0044815,GO:0070013,GO:0098687,GO:0140030,GO:0140034 1.1.1.31 ko:K00020 ko00280,ko01100,map00280,map01100 - R05066 RC00099 ko00000,ko00001,ko01000 - - - NAD_binding_11,NAD_binding_2,PWWP k59_334678_1 1283300.ATXB01000001_gene847 4.96e-91 285.0 COG1154@1|root,COG1154@2|Bacteria,1MUSJ@1224|Proteobacteria,1RNQD@1236|Gammaproteobacteria,1XDS0@135618|Methylococcales 135618|Methylococcales H Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) dxs - 2.2.1.7 ko:K01662 ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130 M00096 R05636 RC00032 ko00000,ko00001,ko00002,ko01000 - - - DXP_synthase_N,Transket_pyr,Transketolase_C k59_498020_1 316407.85674808 6.02e-102 295.0 COG0394@1|root,COG0394@2|Bacteria,1N0DZ@1224|Proteobacteria,1S92S@1236|Gammaproteobacteria,3XPM0@561|Escherichia 1236|Gammaproteobacteria T low molecular weight etp GO:0000271,GO:0003674,GO:0003824,GO:0004721,GO:0004725,GO:0005975,GO:0005976,GO:0006464,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009242,GO:0009987,GO:0016051,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019538,GO:0033692,GO:0034637,GO:0034645,GO:0035335,GO:0036211,GO:0042578,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044267,GO:0046377,GO:0071704,GO:0140096,GO:1901135,GO:1901137,GO:1901564,GO:1901576 3.1.3.48 ko:K01104,ko:K20945 ko05111,map05111 - - - ko00000,ko00001,ko01000 - - - LMWPc k59_1631361_1 868131.MSWAN_1775 6.78e-09 58.2 COG1309@1|root,arCOG02646@2157|Archaea 2157|Archaea K COG1309 Transcriptional regulator - - - ko:K16137 - - - - ko00000,ko03000 - - - TetR_C_6,TetR_N k59_1631362_1 1144312.PMI09_05352 1.68e-12 72.4 COG1609@1|root,COG1609@2|Bacteria,1R9PE@1224|Proteobacteria,2U2S6@28211|Alphaproteobacteria,4BCDM@82115|Rhizobiaceae 28211|Alphaproteobacteria K Periplasmic binding protein-like domain - - - ko:K02529 - - - - ko00000,ko03000 - - - LacI,Peripla_BP_3 k59_498022_1 247639.MGP2080_08866 9.98e-83 256.0 COG2066@1|root,COG2066@2|Bacteria,1MWB5@1224|Proteobacteria,1RMY9@1236|Gammaproteobacteria,1J9TJ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Glutaminase glsA GO:0003674,GO:0003824,GO:0004359,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006541,GO:0006543,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009056,GO:0009058,GO:0009063,GO:0009064,GO:0009065,GO:0009084,GO:0009268,GO:0009628,GO:0009987,GO:0010447,GO:0016043,GO:0016053,GO:0016054,GO:0016787,GO:0016810,GO:0016811,GO:0019752,GO:0022607,GO:0040008,GO:0043436,GO:0043648,GO:0043650,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044281,GO:0044282,GO:0044283,GO:0045926,GO:0046394,GO:0046395,GO:0048519,GO:0050789,GO:0050896,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0065003,GO:0065007,GO:0071704,GO:0071840,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1901607 3.5.1.2 ko:K01425 ko00220,ko00250,ko00471,ko01100,ko04724,ko04727,ko04964,ko05206,ko05230,map00220,map00250,map00471,map01100,map04724,map04727,map04964,map05206,map05230 - R00256,R01579 RC00010,RC02798 ko00000,ko00001,ko01000 - - e_coli_core.b0485,iAF1260.b0485,iB21_1397.B21_00441,iBWG_1329.BWG_0366,iECBD_1354.ECBD_3171,iECB_1328.ECB_00436,iECDH10B_1368.ECDH10B_0442,iECDH1ME8569_1439.ECDH1ME8569_0469,iECD_1391.ECD_00436,iECO111_1330.ECO111_0520,iETEC_1333.ETEC_0537,iEcDH1_1363.EcDH1_3125,iJO1366.b0485,iJR904.b0485,iUMNK88_1353.UMNK88_538,iY75_1357.Y75_RS02500 Glutaminase k59_900105_1 702113.PP1Y_AT21311 2.16e-114 353.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2TQS3@28211|Alphaproteobacteria,2K07A@204457|Sphingomonadales 204457|Sphingomonadales T signal transduction protein containing a membrane domain, an EAL and a GGDEF domain - - - - - - - - - - - - EAL,GGDEF,PAS_4,PAS_9,PilZ k59_1120591_1 199310.c0251 1.05e-32 117.0 COG0328@1|root,COG0328@2|Bacteria,1RCZ1@1224|Proteobacteria,1S3YC@1236|Gammaproteobacteria,3XNJ9@561|Escherichia 1236|Gammaproteobacteria L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids rnhA GO:0003674,GO:0003676,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005488,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:1901360,GO:1901361,GO:1901363,GO:1901575,GO:1901576 3.1.26.4 ko:K03469 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - RNase_H k59_1120591_2 199310.c0252 2.4e-92 274.0 COG0847@1|root,COG0847@2|Bacteria,1MV8Z@1224|Proteobacteria,1RNHQ@1236|Gammaproteobacteria,3XMNA@561|Escherichia 1236|Gammaproteobacteria L DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease dnaQ GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008408,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0016787,GO:0016788,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0042575,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0044776,GO:0045004,GO:0045005,GO:0046483,GO:0050896,GO:0051716,GO:0061695,GO:0071704,GO:0090304,GO:0090305,GO:1901360,GO:1901576,GO:1902494,GO:1990234 2.7.7.7,3.1.26.4 ko:K02342,ko:K14159 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - RNase_H,RNase_T k59_1120595_1 1430440.MGMSRv2_2853 4.37e-37 136.0 COG2908@1|root,COG2908@2|Bacteria,1MVKD@1224|Proteobacteria,2TSEB@28211|Alphaproteobacteria,2JQH4@204441|Rhodospirillales 204441|Rhodospirillales S Protein conserved in bacteria - - - - - - - - - - - - Metallophos,Metallophos_2 k59_1346115_1 1168034.FH5T_07025 2.41e-53 192.0 COG3250@1|root,COG3250@2|Bacteria,4NF3W@976|Bacteroidetes,2FM0P@200643|Bacteroidia 976|Bacteroidetes G beta-galactosidase - - 3.2.1.23 ko:K01190 ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100 - R01105,R01678,R03355,R04783,R06114 RC00049,RC00452 ko00000,ko00001,ko01000 - - - Bgal_small_N,DUF4981,Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N k59_1743588_1 316058.RPB_3808 2.77e-27 108.0 COG1071@1|root,COG1071@2|Bacteria,1MU5R@1224|Proteobacteria,2U6XP@28211|Alphaproteobacteria,3K406@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria C Dehydrogenase E1 component - - 1.2.4.1 ko:K00161 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230 M00307 R00014,R00209,R01699,R03270 RC00004,RC00027,RC00627,RC02742,RC02744,RC02882 br01601,ko00000,ko00001,ko00002,ko01000 - - - E1_dh k59_277107_1 1198232.CYCME_0528 4.8e-31 112.0 COG0756@1|root,COG0756@2|Bacteria,1RA7P@1224|Proteobacteria,1S233@1236|Gammaproteobacteria,460IN@72273|Thiotrichales 72273|Thiotrichales F This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA dut - 3.6.1.23 ko:K01520 ko00240,ko00983,ko01100,map00240,map00983,map01100 M00053 R02100,R11896 RC00002 ko00000,ko00001,ko00002,ko01000,ko03400 - - - dUTPase k59_1346120_1 1122137.AQXF01000003_gene2089 2.1e-57 198.0 COG1629@1|root,COG1629@2|Bacteria,1QUTW@1224|Proteobacteria,2TW7F@28211|Alphaproteobacteria 28211|Alphaproteobacteria P receptor - - - - - - - - - - - - Plug,TonB_dep_Rec k59_51458_1 102125.Xen7305DRAFT_00016550 8.08e-06 53.5 COG2304@1|root,COG2931@1|root,COG3209@1|root,COG4932@1|root,COG2304@2|Bacteria,COG2931@2|Bacteria,COG3209@2|Bacteria,COG4932@2|Bacteria,1GJ0K@1117|Cyanobacteria,3VMAI@52604|Pleurocapsales 1117|Cyanobacteria MQ SdrD B-like domain - - - - - - - - - - - - RHS_repeat,SdrD_B k59_616914_1 263358.VAB18032_20695 3.47e-07 52.8 COG2267@1|root,COG2267@2|Bacteria,2IBJN@201174|Actinobacteria 201174|Actinobacteria I Alpha/beta hydrolase family - - - - - - - - - - - - Abhydrolase_1,Abhydrolase_6 k59_616914_2 493475.GARC_0774 6.8e-134 393.0 COG0475@1|root,COG0475@2|Bacteria,1QTPK@1224|Proteobacteria,1RXTT@1236|Gammaproteobacteria,46C83@72275|Alteromonadaceae 1236|Gammaproteobacteria P Sodium/hydrogen exchanger family - - - - - - - - - - - - Na_H_Exchanger k59_107497_1 1415778.JQMM01000001_gene104 1.2e-76 240.0 COG0668@1|root,COG0668@2|Bacteria,1N66N@1224|Proteobacteria,1RQWI@1236|Gammaproteobacteria,1J5R8@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Mechanosensitive ion channel - - - - - - - - - - - - MS_channel k59_1120623_1 243277.VC_2092 4.95e-99 300.0 COG0372@1|root,COG0372@2|Bacteria,1MUKX@1224|Proteobacteria,1RNDK@1236|Gammaproteobacteria,1XSCA@135623|Vibrionales 135623|Vibrionales C Belongs to the citrate synthase family gltA - 2.3.3.1 ko:K01647 ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00740 R00351 RC00004,RC00067 br01601,ko00000,ko00001,ko00002,ko01000 - - - Citrate_synt k59_219082_2 1123070.KB899249_gene313 1.41e-35 126.0 COG3152@1|root,COG3152@2|Bacteria,46XRZ@74201|Verrucomicrobia,2IWFY@203494|Verrucomicrobiae 203494|Verrucomicrobiae S Protein of unknown function (DUF805) - - - - - - - - - - - - DUF805 k59_1067820_1 297246.lpp2013 1.06e-71 235.0 COG0018@1|root,COG0018@2|Bacteria,1MU4J@1224|Proteobacteria,1RPRC@1236|Gammaproteobacteria,1JCE1@118969|Legionellales 118969|Legionellales J arginyl-tRNA aminoacylation argS GO:0003674,GO:0003824,GO:0004812,GO:0004814,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006420,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.19 ko:K01887 ko00970,map00970 M00359,M00360 R03646 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d k59_669070_1 1397527.Q670_16835 1.72e-78 248.0 COG0402@1|root,COG0402@2|Bacteria,1MVPA@1224|Proteobacteria,1RN13@1236|Gammaproteobacteria,1XI1A@135619|Oceanospirillales 135619|Oceanospirillales F Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine mtaD - 3.5.4.28,3.5.4.31 ko:K12960 ko00270,ko01100,map00270,map01100 - R09660 RC00477 ko00000,ko00001,ko01000 - - - Amidohydro_1 k59_442823_1 28229.ND2E_2594 8.21e-53 187.0 COG1472@1|root,COG1472@2|Bacteria,1MVIV@1224|Proteobacteria,1RMA0@1236|Gammaproteobacteria,2Q7UX@267889|Colwelliaceae 1236|Gammaproteobacteria G Glycosyl hydrolase family 3 C-terminal domain - - 3.2.1.21 ko:K05349 ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110 - R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040 RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248 ko00000,ko00001,ko01000 - GH3 - Glyco_hydro_3,Glyco_hydro_3_C k59_1743645_1 1500257.JQNM01000002_gene4744 1.76e-23 104.0 COG0010@1|root,COG0010@2|Bacteria,1MVFH@1224|Proteobacteria,2TQSZ@28211|Alphaproteobacteria,4B7AY@82115|Rhizobiaceae 28211|Alphaproteobacteria E Belongs to the arginase family speB - 3.5.3.11 ko:K01480 ko00330,ko01100,map00330,map01100 M00133 R01157 RC00024,RC00329 ko00000,ko00001,ko00002,ko01000 - - - Arginase k59_1687556_2 1117647.M5M_17455 4.65e-36 136.0 COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,1RMWA@1236|Gammaproteobacteria,1J4U6@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria JKL DEAD-box RNA helicase involved in RNA degradation. Has RNA-dependent ATPase activity and unwinds double-stranded RNA rhlB GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009056,GO:0009057,GO:0009987,GO:0010501,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019439,GO:0019904,GO:0034641,GO:0034655,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0070035,GO:0071704,GO:0090304,GO:0097718,GO:0140098,GO:1901360,GO:1901361,GO:1901575 3.6.4.13 ko:K03732 ko03018,map03018 M00394 - - ko00000,ko00001,ko00002,ko01000,ko03019 - - - DEAD,Helicase_C,RhlB k59_443711_1 640081.Dsui_3126 2.05e-106 318.0 COG0535@1|root,COG0535@2|Bacteria,1MUQP@1224|Proteobacteria,2VJD9@28216|Betaproteobacteria,2KUGV@206389|Rhodocyclales 206389|Rhodocyclales C radical SAM protein nirJ - - - - - - - - - - - Fer4_12,Radical_SAM k59_1007395_1 290397.Adeh_2042 1.52e-26 110.0 COG0577@1|root,COG0577@2|Bacteria,1MVCT@1224|Proteobacteria,42MX2@68525|delta/epsilon subdivisions,2WIUV@28221|Deltaproteobacteria,2Z2KR@29|Myxococcales 28221|Deltaproteobacteria V FtsX-like permease family - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_1007395_2 491952.Mar181_1747 6.22e-29 112.0 COG4181@1|root,COG4181@2|Bacteria,1MXG9@1224|Proteobacteria,1RMG1@1236|Gammaproteobacteria,1XJAU@135619|Oceanospirillales 135619|Oceanospirillales Q ABC transporter - - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_1521966_1 1449335.JQLG01000004_gene350 1.38e-61 204.0 COG0531@1|root,COG0531@2|Bacteria 2|Bacteria E amino acid - - - ko:K07076,ko:K16263 - - - - ko00000,ko02000 2.A.3.13 - - AA_permease_2,Usp k59_1579586_2 395019.Bmul_5384 5.1e-45 160.0 COG1140@1|root,COG1140@2|Bacteria,1MW9Q@1224|Proteobacteria,2VJ1V@28216|Betaproteobacteria,1K0UD@119060|Burkholderiaceae 28216|Betaproteobacteria C nitrate reductase beta subunit narH - 1.7.5.1 ko:K00371,ko:K17051 ko00910,ko01120,ko02020,map00910,map01120,map02020 M00529,M00530,M00804 R00798,R01106,R09497 RC02812 ko00000,ko00001,ko00002,ko01000,ko02000 5.A.3.1,5.A.3.8 - - Fer4_11,Nitr_red_bet_C k59_1007405_1 395493.BegalDRAFT_3022 1.49e-69 223.0 COG1472@1|root,COG1472@2|Bacteria,1MVAJ@1224|Proteobacteria,1RMQF@1236|Gammaproteobacteria,45ZWB@72273|Thiotrichales 72273|Thiotrichales G Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide-linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N-acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides nagZ - 3.2.1.52 ko:K01207 ko00520,ko00531,ko01100,ko01501,map00520,map00531,map01100,map01501 M00628 R00022,R05963,R07809,R07810,R10831 RC00049 ko00000,ko00001,ko00002,ko01000 - - - Glyco_hydro_3 k59_1007405_2 1122243.KB903804_gene2099 1.16e-06 48.9 COG1376@1|root,COG1376@2|Bacteria,1RHBG@1224|Proteobacteria,1S6DY@1236|Gammaproteobacteria,3NN3W@468|Moraxellaceae 1236|Gammaproteobacteria S L,D-transpeptidase catalytic domain - - - - - - - - - - - - YkuD k59_335742_2 379066.GAU_1238 2.08e-16 82.8 COG0312@1|root,COG0312@2|Bacteria,1ZUEJ@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Putative modulator of DNA gyrase - - - - - - - - - - - - PmbA_TldD k59_1579606_1 945713.IALB_1868 5.79e-69 224.0 COG1008@1|root,COG1008@2|Bacteria 2|Bacteria C NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoM - 1.6.5.3 ko:K00342 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q5_N,Proton_antipo_M k59_1521987_1 1229909.NSED_09030 2.57e-49 164.0 COG2897@1|root,arCOG02019@2157|Archaea,41SXR@651137|Thaumarchaeota 651137|Thaumarchaeota P Rhodanese Homology Domain - - 2.8.1.1,2.8.1.2 ko:K01011 ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122 - R01931,R03105,R03106 RC00214 ko00000,ko00001,ko01000 - - - Rhodanese k59_498997_1 1411123.JQNH01000001_gene2227 1.01e-28 122.0 COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2TRUI@28211|Alphaproteobacteria 28211|Alphaproteobacteria T Adenylate cyclase - - - - - - - - - - - - TPR_16 k59_617883_1 298654.FraEuI1c_1214 4.64e-49 192.0 COG1028@1|root,COG2070@1|root,COG3321@1|root,COG1028@2|Bacteria,COG2070@2|Bacteria,COG3321@2|Bacteria,2H477@201174|Actinobacteria,4EU82@85013|Frankiales 201174|Actinobacteria Q Beta-ketoacyl synthase - - - - - - - - - - - - Acyl_transf_1,KAsynt_C_assoc,KR,Ketoacyl-synt_C,NMO,PP-binding,PS-DH,ketoacyl-synt k59_1579616_1 1122137.AQXF01000001_gene2952 1.39e-67 213.0 COG0135@1|root,COG0135@2|Bacteria,1RA87@1224|Proteobacteria,2U7CH@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Belongs to the TrpF family trpF - 5.3.1.24 ko:K01817 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R03509 RC00945 ko00000,ko00001,ko00002,ko01000 - - - PRAI k59_617884_1 1242864.D187_006709 2.88e-24 106.0 COG0457@1|root,COG0457@2|Bacteria,1QX0H@1224|Proteobacteria,43C18@68525|delta/epsilon subdivisions,2X7BW@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Tetratricopeptide repeat - - - - - - - - - - - - TPR_16,TPR_6,TPR_7 k59_1744539_1 153948.NAL212_2946 2.98e-52 179.0 COG0191@1|root,COG0191@2|Bacteria,1R6TC@1224|Proteobacteria,2VMUH@28216|Betaproteobacteria,3744E@32003|Nitrosomonadales 28216|Betaproteobacteria G PFAM ketose-bisphosphate aldolase, class-II - - 4.1.2.13 ko:K01624 ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00003,M00165,M00167,M00344,M00345 R01068,R01070,R01829,R02568 RC00438,RC00439,RC00603,RC00604 ko00000,ko00001,ko00002,ko01000 - - - F_bP_aldolase k59_1121607_1 870187.Thini_1077 3.09e-06 52.8 COG0438@1|root,COG0561@1|root,COG0438@2|Bacteria,COG0561@2|Bacteria,1MWVX@1224|Proteobacteria,1RSR5@1236|Gammaproteobacteria,4607W@72273|Thiotrichales 72273|Thiotrichales M sucrose phosphate synthase, sucrose phosphatase-like domain, bacterial - - 2.4.1.14 ko:K00696 ko00500,ko01100,map00500,map01100 - R00766 RC00005,RC00028,RC02748 ko00000,ko00001,ko01000 - GT4 - Glyco_transf_4,Glycos_transf_1,S6PP,Sucrose_synth k59_1303483_2 1168065.DOK_13359 3.65e-27 101.0 COG0316@1|root,COG0316@2|Bacteria,1RHCW@1224|Proteobacteria,1S675@1236|Gammaproteobacteria,1J65U@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Iron-sulfur cluster insertion protein ErpA erpA GO:0003674,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006091,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009060,GO:0009061,GO:0009987,GO:0010467,GO:0015980,GO:0016043,GO:0016226,GO:0019538,GO:0022607,GO:0031163,GO:0043167,GO:0043169,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0046872,GO:0046914,GO:0048037,GO:0051186,GO:0051536,GO:0051537,GO:0051539,GO:0051540,GO:0051604,GO:0055114,GO:0071704,GO:0071840,GO:1901564 - ko:K15724 - - - - ko00000 - - - Fe-S_biosyn k59_173708_1 1232437.KL662025_gene933 1.48e-15 74.3 COG0159@1|root,COG0159@2|Bacteria,1MXJV@1224|Proteobacteria,42N5B@68525|delta/epsilon subdivisions,2WJX4@28221|Deltaproteobacteria,2MIHZ@213118|Desulfobacterales 28221|Deltaproteobacteria E The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate trpA - 4.2.1.20 ko:K01695 ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230 M00023 R00674,R02340,R02722 RC00209,RC00210,RC00700,RC00701,RC02868 ko00000,ko00001,ko00002,ko01000 - - - Trp_syntA k59_229867_1 316407.4062691 3.01e-139 397.0 COG1940@1|root,COG1940@2|Bacteria,1MU94@1224|Proteobacteria,1RNHE@1236|Gammaproteobacteria,3XN5F@561|Escherichia 1236|Gammaproteobacteria F Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P nagK GO:0003674,GO:0003824,GO:0005975,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0019200,GO:0044237,GO:0044238,GO:0044262,GO:0045127,GO:0046835,GO:0071704 2.7.1.2,2.7.1.59 ko:K00845,ko:K00884 ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200 M00001,M00549 R00299,R01201,R01600,R01786 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - iE2348C_1286.E2348C_1211,iEcHS_1320.EcHS_A1241,iEcolC_1368.EcolC_2482 ROK k59_229867_2 316407.4062692 2.06e-39 137.0 COG0846@1|root,COG0846@2|Bacteria,1MUK1@1224|Proteobacteria,1RMX5@1236|Gammaproteobacteria,3XMVH@561|Escherichia 1236|Gammaproteobacteria K NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form cobB GO:0002252,GO:0002376,GO:0003674,GO:0003824,GO:0006464,GO:0006476,GO:0006807,GO:0006935,GO:0006950,GO:0006952,GO:0008150,GO:0008152,GO:0009605,GO:0009607,GO:0009615,GO:0009987,GO:0016787,GO:0016810,GO:0016811,GO:0018193,GO:0018205,GO:0019213,GO:0019538,GO:0033558,GO:0034979,GO:0034983,GO:0035601,GO:0036048,GO:0036049,GO:0036055,GO:0036211,GO:0040011,GO:0042221,GO:0042330,GO:0043170,GO:0043207,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0050896,GO:0051607,GO:0051704,GO:0051707,GO:0071704,GO:0098542,GO:0098732,GO:0140096,GO:1901564 - ko:K12410 - - - - ko00000,ko01000 - - - SIR2 k59_229871_1 794903.OPIT5_30195 5.5e-54 176.0 COG2353@1|root,COG2353@2|Bacteria,46WNH@74201|Verrucomicrobia,3K86P@414999|Opitutae 414999|Opitutae S Belongs to the UPF0312 family - - - - - - - - - - - - YceI k59_795070_2 1122138.AQUZ01000004_gene1038 3e-35 125.0 2BGK0@1|root,32AID@2|Bacteria,2GQ1A@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - HK97-gp10_like k59_795070_3 888439.HMPREF9240_01020 9.81e-12 72.0 COG5412@1|root,COG5412@2|Bacteria,2IH91@201174|Actinobacteria 201174|Actinobacteria E phage tail tape measure protein - - - - - - - - - - - - - k59_117294_1 1123368.AUIS01000007_gene2783 1.56e-35 132.0 arCOG05916@1|root,30GTU@2|Bacteria,1RDX8@1224|Proteobacteria,1SNV0@1236|Gammaproteobacteria,2NCJR@225057|Acidithiobacillales 225057|Acidithiobacillales - - - - - - - - - - - - - - - k59_1246933_2 743836.AYNA01000044_gene1163 6.63e-11 64.7 COG3409@1|root,COG3409@2|Bacteria 2|Bacteria M Peptidoglycan-binding domain 1 protein - - - - - - - - - - - - Glyco_hydro_19,PG_binding_1,Peptidase_M23,Peptidase_M74 k59_1416173_1 1123279.ATUS01000001_gene865 4.37e-72 236.0 COG0326@1|root,COG0326@2|Bacteria,1MUUE@1224|Proteobacteria,1RNWD@1236|Gammaproteobacteria,1J4YG@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O Molecular chaperone. Has ATPase activity htpG GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006950,GO:0006974,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0033554,GO:0042623,GO:0042802,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716 - ko:K04079 ko04141,ko04151,ko04217,ko04612,ko04621,ko04626,ko04657,ko04659,ko04914,ko04915,ko05200,ko05215,ko05418,map04141,map04151,map04217,map04612,map04621,map04626,map04657,map04659,map04914,map04915,map05200,map05215,map05418 - - - ko00000,ko00001,ko01009,ko03029,ko03051,ko03110,ko04131,ko04147 - - - HATPase_c,HATPase_c_3,HSP90 k59_738819_1 1415778.JQMM01000001_gene588 4.08e-31 116.0 2AEBT@1|root,31468@2|Bacteria,1RC39@1224|Proteobacteria,1S7QQ@1236|Gammaproteobacteria,1J6HS@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_738819_2 1415778.JQMM01000001_gene589 2.52e-24 101.0 COG0534@1|root,COG0534@2|Bacteria,1MV6B@1224|Proteobacteria,1RPGF@1236|Gammaproteobacteria,1J4H3@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria V COG0534 Na -driven multidrug efflux pump dinF - - ko:K03327 - - - - ko00000,ko02000 2.A.66.1 - - MatE k59_1698778_1 391587.KAOT1_21267 7.72e-58 189.0 COG0026@1|root,COG0026@2|Bacteria,4NEGE@976|Bacteroidetes,1HXZB@117743|Flavobacteriia 976|Bacteroidetes F Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) purK - 6.3.4.18 ko:K01589 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R07404 RC01927 ko00000,ko00001,ko00002,ko01000 - - - ATP-grasp k59_1698778_2 1122225.AULQ01000008_gene1284 4.23e-182 513.0 COG0563@1|root,COG0634@1|root,COG0563@2|Bacteria,COG0634@2|Bacteria,4NG7J@976|Bacteroidetes,1HWR5@117743|Flavobacteriia 976|Bacteroidetes F Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism adk - 2.7.4.3 ko:K00939 ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130 M00049 R00127,R01547,R11319 RC00002 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ADK,Pribosyltran k59_512338_1 748247.AZKH_0434 8.54e-134 391.0 COG0161@1|root,COG0161@2|Bacteria,1MU2N@1224|Proteobacteria,2VKRZ@28216|Betaproteobacteria,2KZSM@206389|Rhodocyclales 206389|Rhodocyclales H Aminotransferase class-III - - 2.6.1.18 ko:K00822 ko00280,ko00410,ko00640,ko01100,map00280,map00410,map00640,map01100 - R00907,R04187 RC00008,RC00062,RC00160 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_3 k59_569009_2 379066.GAU_3001 0.000958 45.1 COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,1ZUC3@142182|Gemmatimonadetes 142182|Gemmatimonadetes KLT Protein kinase domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase k59_1303513_1 1094553.MCS_01082 1.52e-07 55.5 COG1686@1|root,COG1686@2|Bacteria,1MUU7@1224|Proteobacteria,2TT24@28211|Alphaproteobacteria,48TRI@772|Bartonellaceae 28211|Alphaproteobacteria M Beta-lactamase enzyme family dacA3 - 3.4.16.4 ko:K01286 - - - - ko00000,ko01000 - - - Peptidase_S11 k59_1303513_2 1122185.N792_01045 3.19e-06 52.4 COG0797@1|root,COG0797@2|Bacteria,1MZ8S@1224|Proteobacteria,1RMCG@1236|Gammaproteobacteria,1X3Q2@135614|Xanthomonadales 135614|Xanthomonadales M Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides rlpA - - ko:K03642 - - - - ko00000 - - - DPBB_1,SPOR k59_1077191_1 870187.Thini_1478 5.95e-44 156.0 COG0598@1|root,COG0598@2|Bacteria,1MX09@1224|Proteobacteria,1T05M@1236|Gammaproteobacteria,463RQ@72273|Thiotrichales 72273|Thiotrichales P CorA-like Mg2+ transporter protein - - - - - - - - - - - - CorA k59_117312_2 1121912.AUHD01000003_gene3087 3.55e-125 365.0 COG3842@1|root,COG3842@2|Bacteria,4NEZ6@976|Bacteroidetes,1HXA2@117743|Flavobacteriia 976|Bacteroidetes E ABC transporter fbpC2 - 3.6.3.30 ko:K02010 ko02010,map02010 M00190 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.10 - - ABC_tran,TOBE_2 k59_1642469_1 261292.Nit79A3_3003 2.98e-99 300.0 COG0624@1|root,COG0624@2|Bacteria,1MW6G@1224|Proteobacteria,2VHRF@28216|Betaproteobacteria,372MG@32003|Nitrosomonadales 28216|Betaproteobacteria E Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls dapE - 3.5.1.18 ko:K01439 ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230 M00016 R02734 RC00064,RC00090 ko00000,ko00001,ko00002,ko01000 - - - M20_dimer,Peptidase_M20 k59_455962_1 756067.MicvaDRAFT_4977 2.46e-48 164.0 COG0410@1|root,COG0410@2|Bacteria,1G0SK@1117|Cyanobacteria,1H7CF@1150|Oscillatoriales 1117|Cyanobacteria E Amino acid amide ABC transporter ATP-binding protein 2, HAAT family - - - ko:K01996 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - ABC_tran k59_625406_1 96561.Dole_1470 2.06e-34 135.0 COG0457@1|root,COG2203@1|root,COG2204@1|root,COG0457@2|Bacteria,COG2203@2|Bacteria,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,43BR8@68525|delta/epsilon subdivisions,2X724@28221|Deltaproteobacteria 28221|Deltaproteobacteria T PFAM sigma-54 factor interaction domain-containing protein - - - - - - - - - - - - HTH_8,Sigma54_activat k59_229915_1 436308.Nmar_0232 1.17e-18 79.7 COG1371@1|root,arCOG04055@2157|Archaea,41SU0@651137|Thaumarchaeota 651137|Thaumarchaeota S Archease protein family (MTH1598/TM1083) - - - - - - - - - - - - Archease k59_229915_2 706587.Desti_2409 4.4e-62 196.0 COG1765@1|root,COG1765@2|Bacteria,1MWPR@1224|Proteobacteria,42S3G@68525|delta/epsilon subdivisions,2WNET@28221|Deltaproteobacteria,2MQWH@213462|Syntrophobacterales 28221|Deltaproteobacteria O OsmC-like protein - - - - - - - - - - - - OsmC k59_60832_1 1122137.AQXF01000003_gene1881 3.59e-117 342.0 COG0057@1|root,COG0057@2|Bacteria,1MU93@1224|Proteobacteria,2TR6E@28211|Alphaproteobacteria 28211|Alphaproteobacteria G Belongs to the glyceraldehyde-3-phosphate dehydrogenase family gapA GO:0000166,GO:0003674,GO:0003824,GO:0004365,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0036094,GO:0043891,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0097159,GO:1901265,GO:1901363 1.2.1.12 ko:K00134 ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01061 RC00149 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - Gp_dh_C,Gp_dh_N k59_60832_2 1122137.AQXF01000003_gene1882 3.14e-40 143.0 COG0126@1|root,COG0126@2|Bacteria,1MUNU@1224|Proteobacteria,2TSKQ@28211|Alphaproteobacteria 28211|Alphaproteobacteria F Belongs to the phosphoglycerate kinase family pgk GO:0003674,GO:0003824,GO:0004618,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016052,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576 2.7.2.3 ko:K00927 ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01512 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000,ko04147 - - - PGK k59_173747_1 316407.1742086 1.05e-43 150.0 COG0583@1|root,COG0583@2|Bacteria,1MU8N@1224|Proteobacteria,1RN7T@1236|Gammaproteobacteria,3XMHJ@561|Escherichia 1236|Gammaproteobacteria K This protein is a positive regulator of gene expression for the cysteine regulon cysB GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0009314,GO:0009628,GO:0010165,GO:0010212,GO:0042802,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0097159,GO:1901363 - ko:K13634 - - - - ko00000,ko03000 - - - HTH_1,LysR_substrate k59_1472886_1 1131266.ARWQ01000028_gene1022 1.87e-93 289.0 COG1866@1|root,arCOG06073@2157|Archaea,41SE5@651137|Thaumarchaeota 651137|Thaumarchaeota C Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA pckA - 4.1.1.49 ko:K01610 ko00010,ko00020,ko00620,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00710,map01100,map01110,map01120,map01130,map01200 M00003,M00170 R00341 RC00002,RC02741 ko00000,ko00001,ko00002,ko01000 - - - PEPCK_ATP k59_796075_1 1123366.TH3_12810 0.0002 43.9 COG3829@1|root,COG3829@2|Bacteria,1RH32@1224|Proteobacteria,2U79H@28211|Alphaproteobacteria,2JS7C@204441|Rhodospirillales 204441|Rhodospirillales KT COG2202 FOG PAS PAC domain - - - - - - - - - - - - PAS_3 k59_796075_2 224911.27348575 2.68e-24 111.0 COG0840@1|root,COG2770@1|root,COG0840@2|Bacteria,COG2770@2|Bacteria,1MU9B@1224|Proteobacteria,2TQR7@28211|Alphaproteobacteria,3JSI9@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria NT chemotaxis MA20_39440 - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - HAMP,MCPsignal k59_287721_1 1304275.C41B8_17823 1.81e-87 274.0 COG0122@1|root,COG2169@1|root,COG0122@2|Bacteria,COG2169@2|Bacteria,1QTXM@1224|Proteobacteria,1RNQB@1236|Gammaproteobacteria 1236|Gammaproteobacteria K COG2169 Adenosine deaminase ada - 3.2.2.21 ko:K13529 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03000,ko03400 - - - Ada_Zn_binding,AlkA_N,HTH_18,HhH-GPD k59_852529_1 316274.Haur_0419 2.65e-23 103.0 COG2374@1|root,COG2374@2|Bacteria,2G82K@200795|Chloroflexi,374Y1@32061|Chloroflexia 32061|Chloroflexia S PFAM Endonuclease exonuclease phosphatase - - - ko:K07004 - - - - ko00000 - - - Exo_endo_phos,LTD k59_5052_1 436308.Nmar_1431 2.18e-28 109.0 COG0084@1|root,arCOG00891@2157|Archaea,41SGP@651137|Thaumarchaeota 651137|Thaumarchaeota L TatD related DNase - - - ko:K03424 - - - - ko00000,ko01000 - - - TatD_DNase k59_5052_2 436308.Nmar_1432 1.75e-33 116.0 COG2036@1|root,arCOG02144@2157|Archaea,41T91@651137|Thaumarchaeota 651137|Thaumarchaeota L transcription factor (CBF NF-Y) - - - - - - - - - - - - CBFD_NFYB_HMF k59_1643464_1 1158165.KB898872_gene1134 1.68e-35 139.0 COG0642@1|root,COG2202@1|root,COG5002@1|root,COG2202@2|Bacteria,COG2205@2|Bacteria,COG5002@2|Bacteria,1NRP8@1224|Proteobacteria,1T44K@1236|Gammaproteobacteria,1WXW4@135613|Chromatiales 135613|Chromatiales T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA,PAS,PAS_9,Response_reg k59_287728_1 111780.Sta7437_0343 1.17e-14 81.6 COG1198@1|root,COG1198@2|Bacteria,1G2IZ@1117|Cyanobacteria,3VHXH@52604|Pleurocapsales 1117|Cyanobacteria L Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA priA GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006268,GO:0006270,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0033554,GO:0034641,GO:0034645,GO:0042623,GO:0043138,GO:0043140,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0046483,GO:0050896,GO:0051276,GO:0051716,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360,GO:1901576 - ko:K04066 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,Helicase_C k59_5057_1 1056820.KB900663_gene3875 2.37e-16 79.3 COG1508@1|root,COG1508@2|Bacteria,1MW4V@1224|Proteobacteria,1RMY0@1236|Gammaproteobacteria,2PMQ3@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria K Sigma-54 factor, Activator interacting domain (AID) rpoN GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0006355,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032991,GO:0032993,GO:0043565,GO:0044212,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2001141 - ko:K03092 ko02020,ko05111,map02020,map05111 - - - ko00000,ko00001,ko03021 - - - Sigma54_AID,Sigma54_CBD,Sigma54_DBD k59_5057_2 1123487.KB892857_gene2371 2.32e-31 116.0 COG1137@1|root,COG1137@2|Bacteria,1MU8M@1224|Proteobacteria,2VH29@28216|Betaproteobacteria,2KUNS@206389|Rhodocyclales 206389|Rhodocyclales S ABC-type (Unclassified) transport system, ATPase component - - - ko:K06861 ko02010,map02010 M00320 - - ko00000,ko00001,ko00002,ko01000,ko02000 1.B.42.1 - - ABC_tran,BCA_ABC_TP_C k59_1586594_1 436308.Nmar_1129 1.4e-06 55.5 COG3794@1|root,arCOG02926@2157|Archaea 2157|Archaea C PFAM blue (type 1) copper domain protein - - - - - - - - - - - - Copper-bind k59_174707_2 1168034.FH5T_06360 1.69e-73 226.0 COG1484@1|root,COG1484@2|Bacteria,4NFE0@976|Bacteroidetes,2FPQ9@200643|Bacteroidia 976|Bacteroidetes L COG1484 DNA replication protein - - - - - - - - - - - - IstB_IS21 k59_5072_1 207954.MED92_10449 1.18e-39 143.0 COG3287@1|root,COG3287@2|Bacteria,1MVUZ@1224|Proteobacteria,1RY7N@1236|Gammaproteobacteria,1XIZ8@135619|Oceanospirillales 135619|Oceanospirillales S FIST N domain - - - - - - - - - - - - FIST,FIST_C k59_1304398_1 935863.AWZR01000005_gene2148 2.52e-26 109.0 COG4907@1|root,COG4907@2|Bacteria,1MXPY@1224|Proteobacteria,1RQUG@1236|Gammaproteobacteria,1X59Q@135614|Xanthomonadales 135614|Xanthomonadales S Predicted membrane protein (DUF2207) - - - - - - - - - - - - DUF2207 k59_1304398_2 999425.HMPREF9186_00809 2.34e-44 152.0 COG1704@1|root,COG1704@2|Bacteria,1V1G7@1239|Firmicutes,4IR1J@91061|Bacilli 91061|Bacilli S LemA family lemA - - ko:K03744 - - - - ko00000 - - - LemA k59_1191555_1 1248916.ANFY01000011_gene1222 2.45e-22 99.4 COG1574@1|root,COG1574@2|Bacteria,1MWP2@1224|Proteobacteria,2TXAW@28211|Alphaproteobacteria 28211|Alphaproteobacteria S metal-dependent hydrolase with the TIM-barrel fold - - - - - - - - - - - - Amidohydro_3 k59_344258_1 349521.HCH_00541 1.62e-19 96.7 COG0643@1|root,COG0745@1|root,COG2198@1|root,COG0643@2|Bacteria,COG0745@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,1RMS6@1236|Gammaproteobacteria,1XHMP@135619|Oceanospirillales 135619|Oceanospirillales T Chemotaxis protein histidine kinase and related chpA - - ko:K02487,ko:K06596 ko02020,ko02025,map02020,map02025 M00507 - - ko00000,ko00001,ko00002,ko01001,ko02022,ko02035 - - - CheW,H-kinase_dim,HATPase_c,Hpt,Response_reg k59_626350_1 379731.PST_0453 3.44e-39 144.0 COG2010@1|root,COG2010@2|Bacteria,1MV6D@1224|Proteobacteria,1RMYF@1236|Gammaproteobacteria,1Z39H@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria C Cytochrome C oxidase, cbb3-type, subunit III - - - - - - - - - - - - Cytochrom_C,Cytochrome_CBB3 k59_5092_1 316407.1799660 8.91e-119 348.0 COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,1RN5B@1236|Gammaproteobacteria,3XP0F@561|Escherichia 1236|Gammaproteobacteria E Glutamate--pyruvate aminotransferase AlaA alaA GO:0003674,GO:0003824,GO:0004021,GO:0005488,GO:0006082,GO:0006090,GO:0006520,GO:0006522,GO:0006523,GO:0006807,GO:0006950,GO:0006974,GO:0008144,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009058,GO:0009078,GO:0009079,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0019272,GO:0019752,GO:0019842,GO:0030170,GO:0030632,GO:0032787,GO:0033554,GO:0036094,GO:0042221,GO:0042851,GO:0042852,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046144,GO:0046145,GO:0046394,GO:0046416,GO:0046436,GO:0046437,GO:0046677,GO:0047635,GO:0048037,GO:0050662,GO:0050896,GO:0051716,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.6.1.2,2.6.1.66 ko:K14260 ko00220,ko00250,ko00290,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00290,map01100,map01110,map01130,map01210,map01230 - R00258,R01215 RC00006,RC00008,RC00036 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_1_2 k59_796126_2 640081.Dsui_2690 3.82e-54 177.0 COG0020@1|root,COG0020@2|Bacteria,1MVP1@1224|Proteobacteria,2VH2E@28216|Betaproteobacteria,2KV64@206389|Rhodocyclales 206389|Rhodocyclales H Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids uppS - 2.5.1.31 ko:K00806 ko00900,ko01110,map00900,map01110 - R06447 RC00279,RC02839 ko00000,ko00001,ko01000,ko01006 - - - Prenyltransf k59_908737_1 555793.WSK_0475 5.17e-11 62.0 COG0058@1|root,COG0058@2|Bacteria,1MW4J@1224|Proteobacteria,2TRER@28211|Alphaproteobacteria,2K2A2@204457|Sphingomonadales 204457|Sphingomonadales G Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties glgP - 2.4.1.1 ko:K00688 ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931 - R02111 - ko00000,ko00001,ko01000 - GT35 - Phosphorylase k59_908737_2 1123270.ATUR01000003_gene797 3.84e-51 176.0 COG0025@1|root,COG0025@2|Bacteria,1MW5T@1224|Proteobacteria,2TQME@28211|Alphaproteobacteria,2K1QP@204457|Sphingomonadales 204457|Sphingomonadales P Sodium/hydrogen exchanger family - - - ko:K03316 - - - - ko00000 2.A.36 - - Na_H_Exchanger k59_1417202_1 1123367.C666_09720 1.59e-06 49.7 COG0668@1|root,COG0668@2|Bacteria,1N596@1224|Proteobacteria,2VQ9J@28216|Betaproteobacteria 28216|Betaproteobacteria M mechanosensitive ion channel - - - ko:K03442 - - - - ko00000,ko02000 1.A.23.2 - - MS_channel,TM_helix k59_1643502_2 1229909.NSED_08125 4.56e-82 251.0 COG0506@1|root,arCOG06322@2157|Archaea,41SY1@651137|Thaumarchaeota 651137|Thaumarchaeota E Proline dehydrogenase - - - ko:K00318 ko00330,ko01100,ko01110,ko01130,map00330,map01100,map01110,map01130 - R10507 RC00083 ko00000,ko00001,ko01000 - - - Pro_dh k59_400526_1 1358423.N180_02870 0.000506 45.8 2DEUM@1|root,2ZPBE@2|Bacteria,4P78P@976|Bacteroidetes,1IZYU@117747|Sphingobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_1022427_1 247633.GP2143_09795 1.19e-19 94.0 COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,1RMUR@1236|Gammaproteobacteria 1236|Gammaproteobacteria V Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation - - - - - - - - - - - - ABC_membrane,ABC_tran k59_626384_1 1444770.AF72_01930 2.23e-16 85.9 COG0845@1|root,COG0845@2|Bacteria,1MUI8@1224|Proteobacteria,1RNK4@1236|Gammaproteobacteria,1X39B@135614|Xanthomonadales 135614|Xanthomonadales M HlyD membrane-fusion protein of T1SS - - - ko:K11003 ko03070,ko05133,map03070,map05133 M00325,M00575 - - ko00000,ko00001,ko00002,ko02000,ko02044 8.A.1.3.1,8.A.1.3.2 - - Biotin_lipoyl_2,HlyD,HlyD_3 k59_1191588_1 927677.ALVU02000002_gene292 1.59e-89 271.0 COG3039@1|root,COG3039@2|Bacteria,1G1EK@1117|Cyanobacteria 1117|Cyanobacteria L PFAM Transposase DDE domain - - - - - - - - - - - - DDE_Tnp_1_3 k59_118187_2 436308.Nmar_0071 6.34e-56 177.0 COG2125@1|root,arCOG01946@2157|Archaea,41SPC@651137|Thaumarchaeota 651137|Thaumarchaeota J Belongs to the eukaryotic ribosomal protein eS6 family rps6e - - ko:K02991 ko01521,ko03010,ko04066,ko04150,ko04151,ko04371,ko04714,ko04910,ko05205,map01521,map03010,map04066,map04150,map04151,map04371,map04714,map04910,map05205 M00177,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S6e k59_965398_1 637910.ROD_23321 5.26e-17 78.6 COG4133@1|root,COG4133@2|Bacteria,1MZPC@1224|Proteobacteria,1S3R2@1236|Gammaproteobacteria,3WX7P@544|Citrobacter 1236|Gammaproteobacteria P once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system ccmA GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0009898,GO:0015232,GO:0015886,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019897,GO:0019898,GO:0022857,GO:0031224,GO:0031234,GO:0032991,GO:0042623,GO:0043190,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051181,GO:0051184,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0098533,GO:0098552,GO:0098562,GO:0098796,GO:0098797,GO:1901678,GO:1902494,GO:1902495,GO:1904949,GO:1990351 3.6.3.41 ko:K02193 ko02010,map02010 M00259 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.107 - iAPECO1_1312.APECO1_4358,iECED1_1282.ECED1_2666,iECS88_1305.ECS88_2348,iECUMN_1333.ECUMN_2536,iLF82_1304.LF82_0273,iNRG857_1313.NRG857_11170,iUMN146_1321.UM146_05800,iUTI89_1310.UTI89_C2479 ABC_tran k59_965398_2 1122194.AUHU01000002_gene2857 1.47e-60 194.0 COG2386@1|root,COG2386@2|Bacteria,1NJB0@1224|Proteobacteria,1RRFJ@1236|Gammaproteobacteria,466DX@72275|Alteromonadaceae 1236|Gammaproteobacteria O Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes ccmB GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0031224,GO:0031226,GO:0032991,GO:0042623,GO:0043190,GO:0044425,GO:0044459,GO:0044464,GO:0071944,GO:0098533,GO:0098796,GO:0098797,GO:1902494,GO:1902495,GO:1904949,GO:1990351 - ko:K02194 ko02010,map02010 M00259 - - ko00000,ko00001,ko00002,ko02000 3.A.1.107 - iECO111_1330.ECO111_2936,iYL1228.KPN_02080 CcmB k59_344309_1 1173028.ANKO01000052_gene1623 5.11e-27 119.0 COG0515@1|root,COG3899@1|root,COG4191@1|root,COG0515@2|Bacteria,COG3899@2|Bacteria,COG4191@2|Bacteria,1GC6Z@1117|Cyanobacteria,1H6Y9@1150|Oscillatoriales 1117|Cyanobacteria KLT Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - AAA_16,GAF,HATPase_c,HisKA,Pkinase k59_344317_2 926569.ANT_19400 1.43e-49 164.0 COG2386@1|root,COG2386@2|Bacteria,2G6TN@200795|Chloroflexi 200795|Chloroflexi O PFAM cytochrome c-type biogenesis protein CcmB ccmB - - ko:K02194 ko02010,map02010 M00259 - - ko00000,ko00001,ko00002,ko02000 3.A.1.107 - - CcmB k59_1530355_1 338963.Pcar_0306 1.78e-82 252.0 COG0668@1|root,COG0668@2|Bacteria,1N596@1224|Proteobacteria,42PH4@68525|delta/epsilon subdivisions,2WME5@28221|Deltaproteobacteria,43T1N@69541|Desulfuromonadales 28221|Deltaproteobacteria M Conserved TM helix - - - ko:K03442 - - - - ko00000,ko02000 1.A.23.2 - - MS_channel,TM_helix k59_1586683_1 1249627.D779_0418 3.91e-59 188.0 COG2716@1|root,COG2716@2|Bacteria,1R7W7@1224|Proteobacteria,1RSDP@1236|Gammaproteobacteria,1WWJB@135613|Chromatiales 135613|Chromatiales E PFAM Amino acid-binding ACT - - - ko:K03567 ko02026,map02026 - - - ko00000,ko00001,ko03000 - - - ACT_6 k59_1078380_2 214092.YPO3146 2.91e-09 60.1 COG1522@1|root,COG1522@2|Bacteria,1RDB3@1224|Proteobacteria,1S2E1@1236|Gammaproteobacteria,41D8G@629|Yersinia 1236|Gammaproteobacteria K transcriptional regulator YbaO ybaO - - ko:K05800 - - - - ko00000,ko03000 - - - AsnC_trans_reg,HTH_24 k59_1078380_3 305900.GV64_10030 3.1e-81 248.0 COG1028@1|root,COG1028@2|Bacteria,1P1U4@1224|Proteobacteria,1RR3M@1236|Gammaproteobacteria,1XR3Z@135619|Oceanospirillales 135619|Oceanospirillales IQ short-chain dehydrogenase - - - - - - - - - - - - adh_short_C2 k59_965414_1 436308.Nmar_0011 1.69e-257 721.0 COG0464@1|root,arCOG01308@2157|Archaea,41SX8@651137|Thaumarchaeota 651137|Thaumarchaeota O Cell division protein 48 (CDC48), domain 2 - - - ko:K13525 ko04141,ko05134,map04141,map05134 M00400,M00403 - - ko00000,ko00001,ko00002,ko03019,ko04131,ko04147 3.A.16.1 - - AAA,CDC48_2,CDC48_N k59_965428_1 1123400.KB904748_gene291 1.04e-33 121.0 COG0727@1|root,COG0727@2|Bacteria,1N027@1224|Proteobacteria,1S949@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Fe-S-cluster oxidoreductase ykgJ - - ko:K06940 - - - - ko00000 - - - CxxCxxCC k59_1022459_1 1123234.AUKI01000019_gene551 2.2e-10 67.4 COG0457@1|root,COG3629@1|root,COG5616@1|root,COG0457@2|Bacteria,COG3629@2|Bacteria,COG5616@2|Bacteria,4NFW7@976|Bacteroidetes,1HZQR@117743|Flavobacteriia 976|Bacteroidetes K COGs COG5616 integral membrane protein - - - - - - - - - - - - ANAPC3,Guanylate_cyc,HTH_18,TPR_8 k59_975499_1 1120950.KB892764_gene5600 3.32e-11 66.6 COG3214@1|root,COG3214@2|Bacteria,2GJM7@201174|Actinobacteria,4DN5U@85009|Propionibacteriales 201174|Actinobacteria S Winged helix DNA-binding domain - - - ko:K09927 - - - - ko00000 - - - HTH_42 k59_1315620_1 1173024.KI912148_gene3094 6.12e-74 238.0 COG1249@1|root,COG1249@2|Bacteria,1G198@1117|Cyanobacteria,1JKU8@1189|Stigonemataceae 1117|Cyanobacteria C Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain merA - - - - - - - - - - - Pyr_redox_2,Pyr_redox_dim,SNARE_assoc k59_16145_1 1173023.KE650771_gene4342 1.23e-11 69.3 COG3240@1|root,COG4625@1|root,COG3240@2|Bacteria,COG4625@2|Bacteria,1G2WT@1117|Cyanobacteria,1JKJE@1189|Stigonemataceae 1117|Cyanobacteria I Autotransporter beta-domain - - - ko:K12686 - - - - ko00000,ko02000,ko02044 1.B.12.8 - - Autotransporter,Lipase_GDSL k59_1089243_1 1144310.PMI07_003641 6.04e-27 114.0 COG0146@1|root,COG0146@2|Bacteria,1QU46@1224|Proteobacteria,2TVYU@28211|Alphaproteobacteria,4B8UI@82115|Rhizobiaceae 28211|Alphaproteobacteria EQ N-methylhydantoinase B acetone carboxylase, alpha subunit - - 3.5.2.14 ko:K01474 ko00330,ko01100,map00330,map01100 - R03187 RC00632 ko00000,ko00001,ko01000 - - - Hydantoinase_B k59_241760_1 582744.Msip34_0490 0.000232 47.0 COG0288@1|root,COG3339@1|root,COG0288@2|Bacteria,COG3339@2|Bacteria,1MZCY@1224|Proteobacteria,2VV31@28216|Betaproteobacteria,2KN8M@206350|Nitrosomonadales 206350|Nitrosomonadales P Protein of unknown function (DUF1232) - - - - - - - - - - - - DUF1232 k59_241760_2 551789.ATVJ01000003_gene383 2.64e-83 255.0 COG0039@1|root,COG0039@2|Bacteria,1MV57@1224|Proteobacteria,2TSV6@28211|Alphaproteobacteria,43WMI@69657|Hyphomonadaceae 28211|Alphaproteobacteria C Catalyzes the reversible oxidation of malate to oxaloacetate mdh - 1.1.1.37 ko:K00024 ko00020,ko00270,ko00620,ko00630,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00270,map00620,map00630,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740 R00342,R07136 RC00031 ko00000,ko00001,ko00002,ko01000 - - - Ldh_1_C,Ldh_1_N k59_580828_1 402777.KB235903_gene442 6.79e-06 54.3 COG0642@1|root,COG0784@1|root,COG2202@1|root,COG0784@2|Bacteria,COG2202@2|Bacteria,COG2205@2|Bacteria,1G09B@1117|Cyanobacteria,1H7M4@1150|Oscillatoriales 1117|Cyanobacteria T Signal transduction histidine kinase, subgroup 1, dimerisation phosphoacceptor domain - - - - - - - - - - - - HATPase_c,HisKA,PAS_3,PAS_4,PAS_9,Response_reg k59_523798_1 706587.Desti_4200 8.15e-87 284.0 COG0188@1|root,COG0188@2|Bacteria,1MUGG@1224|Proteobacteria,42KZ9@68525|delta/epsilon subdivisions,2WJBC@28221|Deltaproteobacteria,2MR01@213462|Syntrophobacterales 28221|Deltaproteobacteria L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrA - 5.99.1.3 ko:K02469 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseA_C,DNA_topoisoIV k59_1654888_1 247634.GPB2148_3605 6.86e-149 436.0 COG3067@1|root,COG3067@2|Bacteria,1MV0F@1224|Proteobacteria,1RPE3@1236|Gammaproteobacteria,1J506@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P Na( ) H( ) antiporter that extrudes sodium in exchange for external protons nhaB GO:0003674,GO:0005215,GO:0005451,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006814,GO:0006873,GO:0006885,GO:0008150,GO:0008324,GO:0009987,GO:0010035,GO:0010038,GO:0010226,GO:0015075,GO:0015077,GO:0015078,GO:0015081,GO:0015291,GO:0015297,GO:0015298,GO:0015299,GO:0015318,GO:0015385,GO:0015491,GO:0015672,GO:0016020,GO:0019725,GO:0022804,GO:0022857,GO:0022890,GO:0030001,GO:0030003,GO:0030004,GO:0030641,GO:0034220,GO:0035725,GO:0042221,GO:0042592,GO:0044464,GO:0045851,GO:0046873,GO:0048878,GO:0050801,GO:0050896,GO:0051179,GO:0051234,GO:0051452,GO:0051453,GO:0055067,GO:0055080,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:0098771,GO:0099516,GO:1902600 - ko:K03314 - - - - ko00000,ko02000 2.A.34.1 - iECP_1309.ECP_1229,iLF82_1304.LF82_1485,iNRG857_1313.NRG857_06055,iUTI89_1310.UTI89_C1372 NhaB k59_1654888_2 981336.F944_01164 4.26e-10 59.7 COG0677@1|root,COG0677@2|Bacteria,1MUC6@1224|Proteobacteria,1RMX0@1236|Gammaproteobacteria,3NIGZ@468|Moraxellaceae 1236|Gammaproteobacteria M Belongs to the UDP-glucose GDP-mannose dehydrogenase family wbpO - - ko:K02474 ko00520,map00520 - R06894 RC00291 ko00000,ko00001,ko01000,ko01005 - - - UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N k59_751377_1 358220.C380_17370 2.38e-112 336.0 COG0683@1|root,COG0683@2|Bacteria,1NHBN@1224|Proteobacteria,2VPWN@28216|Betaproteobacteria,4AC19@80864|Comamonadaceae 28216|Betaproteobacteria E COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component - - - ko:K01999 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - Peripla_BP_6 k59_976591_1 583355.Caka_2399 7.7e-41 142.0 COG1573@1|root,COG1573@2|Bacteria,46UWP@74201|Verrucomicrobia,3K7VU@414999|Opitutae 414999|Opitutae L uracil-dna glycosylase - - - ko:K10800 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - - k59_976591_2 543728.Vapar_3659 3.31e-78 247.0 COG4301@1|root,COG4301@2|Bacteria,1MUCG@1224|Proteobacteria,2VJHK@28216|Betaproteobacteria,4AB1Q@80864|Comamonadaceae 28216|Betaproteobacteria S Histidine-specific methyltransferase, SAM-dependent egtD - - - - - - - - - - - Methyltransf_33 k59_1598849_1 338966.Ppro_2066 8.39e-38 142.0 COG0661@1|root,COG0661@2|Bacteria,1MU1Z@1224|Proteobacteria,42N87@68525|delta/epsilon subdivisions,2WTV9@28221|Deltaproteobacteria 28221|Deltaproteobacteria S pfam abc1 - - - - - - - - - - - - ABC1 k59_1598849_2 760154.Sulba_1109 2.47e-05 44.7 COG3937@1|root,COG3937@2|Bacteria,1P8D3@1224|Proteobacteria,42VTS@68525|delta/epsilon subdivisions,2YQ89@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S granule-associated protein - - - - - - - - - - - - - k59_638527_1 948106.AWZT01000069_gene1022 4.5e-36 130.0 COG3777@1|root,COG3777@2|Bacteria,1P96N@1224|Proteobacteria,2VIUS@28216|Betaproteobacteria,1K08H@119060|Burkholderiaceae 28216|Betaproteobacteria S N-terminal half of MaoC dehydratase - - 4.2.1.153,4.2.1.56 ko:K09709,ko:K18291 ko00660,ko00720,ko01120,ko01200,map00660,map00720,map01120,map01200 M00376 R02491,R09282 RC00730,RC02479 ko00000,ko00001,ko00002,ko01000 - - - MaoC_dehydrat_N k59_1090272_1 1121935.AQXX01000082_gene171 3.74e-93 288.0 COG2224@1|root,COG2224@2|Bacteria,1MWIF@1224|Proteobacteria,1RQAK@1236|Gammaproteobacteria,1XH9M@135619|Oceanospirillales 135619|Oceanospirillales C Catalyzes the first step in the glyoxalate cycle, which converts lipids to carbohydrates aceA - 4.1.3.1 ko:K01637 ko00630,ko01100,ko01110,ko01120,ko01200,map00630,map01100,map01110,map01120,map01200 M00012 R00479 RC00311,RC00313 ko00000,ko00001,ko00002,ko01000 - - - ICL k59_638532_1 1122137.AQXF01000002_gene407 9.25e-86 276.0 COG0013@1|root,COG0013@2|Bacteria,1MU9A@1224|Proteobacteria,2TQV4@28211|Alphaproteobacteria 28211|Alphaproteobacteria J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain alaS GO:0003674,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016597,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.7 ko:K01872 ko00970,map00970 M00359,M00360 R03038 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DHHA1,tRNA-synt_2c,tRNA_SAD k59_74461_1 316407.1736702 4.81e-140 397.0 COG0106@1|root,COG0106@2|Bacteria,1MW6S@1224|Proteobacteria,1RN3M@1236|Gammaproteobacteria,3XNGK@561|Escherichia 1236|Gammaproteobacteria E 1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase hisA GO:0000105,GO:0000162,GO:0003674,GO:0003824,GO:0003949,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0033554,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0050896,GO:0051716,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.3.1.16 ko:K01814 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04640 RC00945 ko00000,ko00001,ko00002,ko01000 - - iSBO_1134.SBO_0850,iSDY_1059.SDY_2217 His_biosynth k59_1203715_1 261292.Nit79A3_0216 5.65e-84 264.0 COG2211@1|root,COG2211@2|Bacteria,1MWSH@1224|Proteobacteria,2VJEQ@28216|Betaproteobacteria,372MX@32003|Nitrosomonadales 28216|Betaproteobacteria G BT1 family - - - - - - - - - - - - BT1 k59_187082_1 391626.OAN307_c45920 6.3e-68 219.0 COG2826@1|root,COG2826@2|Bacteria,1PP49@1224|Proteobacteria,2TRVA@28211|Alphaproteobacteria 28211|Alphaproteobacteria L COG2826 Transposase and inactivated derivatives, IS30 family - - - - - - - - - - - - HTH_38,rve k59_1035105_1 879212.DespoDRAFT_00624 1.84e-106 325.0 COG0471@1|root,COG0471@2|Bacteria,1MU0K@1224|Proteobacteria,42MR7@68525|delta/epsilon subdivisions,2WIKA@28221|Deltaproteobacteria,2MMR4@213118|Desulfobacterales 28221|Deltaproteobacteria P PFAM Citrate transporter - - - - - - - - - - - - CitMHS,TrkA_C k59_1373545_1 1144305.PMI02_01714 1.42e-59 200.0 COG2939@1|root,COG2939@2|Bacteria,1MW05@1224|Proteobacteria,2TS7R@28211|Alphaproteobacteria,2K0U5@204457|Sphingomonadales 204457|Sphingomonadales E peptidase S10 serine carboxypeptidase - - - - - - - - - - - - Peptidase_S10 k59_976618_1 1522072.IL54_1208 7.1e-64 199.0 COG0229@1|root,COG0229@2|Bacteria,1RGWC@1224|Proteobacteria,2U70T@28211|Alphaproteobacteria,2K4P6@204457|Sphingomonadales 204457|Sphingomonadales O conserved domain frequently associated with peptide methionine sulfoxide reductase - - 1.8.4.12 ko:K07305 - - - - ko00000,ko01000 - - - SelR k59_976618_2 1088721.NSU_3573 1.51e-21 93.6 COG0477@1|root,COG2814@2|Bacteria,1MWFH@1224|Proteobacteria,2TR0R@28211|Alphaproteobacteria,2K35P@204457|Sphingomonadales 204457|Sphingomonadales EGP Sugar (and other) transporter - - - ko:K08224 - - - - ko00000,ko02000 2.A.1.36 - - MFS_1,Sugar_tr k59_1146818_1 1122137.AQXF01000001_gene3140 7.1e-51 179.0 COG0154@1|root,COG0154@2|Bacteria,1MWRI@1224|Proteobacteria,2TTJU@28211|Alphaproteobacteria 28211|Alphaproteobacteria J COG0154 Asp-tRNAAsn Glu-tRNAGln amidotransferase A subunit and related amidases - - 3.5.1.4,6.3.5.6,6.3.5.7 ko:K01426,ko:K02433 ko00330,ko00360,ko00380,ko00627,ko00643,ko00970,ko01100,ko01120,map00330,map00360,map00380,map00627,map00643,map00970,map01100,map01120 - R02540,R03096,R03180,R03905,R03909,R04212,R05551,R05590 RC00010,RC00100,RC00950,RC01025 ko00000,ko00001,ko01000,ko03029 - - - Amidase k59_751400_1 566466.NOR53_2591 3.61e-64 207.0 COG2951@1|root,COG2951@2|Bacteria,1MUZ3@1224|Proteobacteria,1RMQ6@1236|Gammaproteobacteria,1J4FD@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M COG2951 Membrane-bound lytic murein transglycosylase B mltB - - ko:K08305 - - - - ko00000,ko01000,ko01011 - GH103 - SLT_2 k59_412514_2 1193128.A200_07508 6.01e-62 202.0 COG0462@1|root,COG0462@2|Bacteria,2GJ9S@201174|Actinobacteria,4CYRD@85004|Bifidobacteriales 201174|Actinobacteria F Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) prs GO:0000287,GO:0003674,GO:0003824,GO:0004749,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006015,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016778,GO:0019637,GO:0019693,GO:0030145,GO:0030312,GO:0040007,GO:0043167,GO:0043169,GO:0044237,GO:0044464,GO:0046390,GO:0046391,GO:0046872,GO:0046914,GO:0071704,GO:0071944,GO:0090407,GO:1901135,GO:1901137,GO:1901576 2.7.6.1 ko:K00948 ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230 M00005 R01049 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - Pribosyl_synth,Pribosyltran_N k59_751403_1 190650.CC_3089 1.5e-09 59.3 COG2130@1|root,COG2130@2|Bacteria,1MUR0@1224|Proteobacteria,2U16B@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Protein of unknown function (DUF2855) - - - - - - - - - - - - DUF2855 k59_751403_2 1417296.U879_05230 9.88e-14 72.8 COG0668@1|root,COG0668@2|Bacteria,1N596@1224|Proteobacteria,2TR7U@28211|Alphaproteobacteria 28211|Alphaproteobacteria M COG0668 Small-conductance mechanosensitive channel mscS - - ko:K03442 - - - - ko00000,ko02000 1.A.23.2 - - MS_channel,TM_helix k59_1090282_1 199310.c5457 1.46e-124 357.0 COG2823@1|root,COG2823@2|Bacteria,1PCIJ@1224|Proteobacteria,1RRGP@1236|Gammaproteobacteria,3XN0N@561|Escherichia 1236|Gammaproteobacteria S hyperosmotic response osmY GO:0005575,GO:0005623,GO:0006457,GO:0006950,GO:0006970,GO:0006972,GO:0008150,GO:0009628,GO:0009987,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0044464,GO:0050896,GO:0061077 - ko:K04065 - - - - ko00000 - - - BON k59_1711900_2 1537994.JQFW01000015_gene1580 5.86e-43 147.0 COG1238@1|root,COG1238@2|Bacteria,1MWED@1224|Proteobacteria,1RPT7@1236|Gammaproteobacteria,4669C@72275|Alteromonadaceae 1236|Gammaproteobacteria S SNARE associated Golgi protein Z012_09465 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - - - - - - - - - - SNARE_assoc k59_1035120_1 511062.GU3_15850 3.22e-36 139.0 COG0659@1|root,COG0659@2|Bacteria,1MWDF@1224|Proteobacteria,1SYC8@1236|Gammaproteobacteria,1Y6KX@135624|Aeromonadales 135624|Aeromonadales P Sulfate permease family - - - ko:K03321 - - - - ko00000,ko02000 2.A.53.3 - - STAS,Sulfate_transp k59_1035120_2 1163617.SCD_n02582 6.64e-62 207.0 COG0659@1|root,COG0659@2|Bacteria,1MWDF@1224|Proteobacteria,2VHKJ@28216|Betaproteobacteria 28216|Betaproteobacteria P Sulfate transporter antisigma-factor antagonist STAS - - - ko:K03321 - - - - ko00000,ko02000 2.A.53.3 - - STAS,Sulfate_transp k59_1146841_1 1054860.KB913030_gene3435 7.72e-36 138.0 COG2197@1|root,COG2197@2|Bacteria,2GKXJ@201174|Actinobacteria 201174|Actinobacteria K PFAM regulatory protein LuxR - - - - - - - - - - - - GerE k59_920995_1 1249627.D779_1005 7.52e-61 211.0 COG0475@1|root,COG1226@1|root,COG0475@2|Bacteria,COG1226@2|Bacteria,1MV34@1224|Proteobacteria,1RNVR@1236|Gammaproteobacteria,1WX9W@135613|Chromatiales 135613|Chromatiales P Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family - - - ko:K03455,ko:K11747 - - - - ko00000,ko02000 2.A.37,2.A.37.1.2 - - Na_H_Exchanger,TrkA_N k59_1656147_1 748658.KB907317_gene268 1.24e-70 222.0 COG0287@1|root,COG0287@2|Bacteria,1QTZA@1224|Proteobacteria,1T20F@1236|Gammaproteobacteria,1WW2D@135613|Chromatiales 135613|Chromatiales E PFAM Prephenate dehydrogenase - - 1.3.1.12 ko:K04517 ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230 M00025 R01728 RC00125 ko00000,ko00001,ko00002,ko01000 - - - PDH k59_1598884_1 224911.27355078 2.7e-16 79.3 COG1414@1|root,COG1414@2|Bacteria,1MY38@1224|Proteobacteria,2TVF7@28211|Alphaproteobacteria,3JU7F@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria K Bacterial transcriptional regulator - - - - - - - - - - - - HTH_IclR,IclR k59_1598884_2 1545915.JROG01000004_gene2231 1.02e-17 82.4 COG1028@1|root,COG1028@2|Bacteria,1MVKN@1224|Proteobacteria,2U301@28211|Alphaproteobacteria,2K0TY@204457|Sphingomonadales 204457|Sphingomonadales IQ short-chain dehydrogenase - - - - - - - - - - - - adh_short k59_1711908_1 158500.BV97_01291 7.27e-84 272.0 COG1629@1|root,COG1629@2|Bacteria,COG4771@2|Bacteria,1MU9K@1224|Proteobacteria,2UNZR@28211|Alphaproteobacteria,2KECI@204457|Sphingomonadales 204457|Sphingomonadales P TonB dependent receptor - - - - - - - - - - - - Plug,TonB_dep_Rec k59_524909_2 1049564.TevJSym_ac00330 3.79e-21 90.9 2CGG3@1|root,33XQ6@2|Bacteria,1NWYE@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_1542789_1 1123053.AUDG01000009_gene3790 3.62e-40 151.0 COG1629@1|root,COG4206@1|root,COG1629@2|Bacteria,COG4206@2|Bacteria,1MXVP@1224|Proteobacteria,1RS4C@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Receptor suxA - - - - - - - - - - - Plug,TonB_dep_Rec k59_921003_1 1463825.JNXC01000023_gene4963 2.41e-98 294.0 COG0411@1|root,COG0411@2|Bacteria,2GMEE@201174|Actinobacteria,4E1TV@85010|Pseudonocardiales 201174|Actinobacteria E pfam abc - - - ko:K01995 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - ABC_tran,BCA_ABC_TP_C k59_1542791_1 999419.HMPREF1077_02572 3.29e-14 76.6 COG0667@1|root,COG0667@2|Bacteria,4NEDK@976|Bacteroidetes,2FPUT@200643|Bacteroidia,22X7V@171551|Porphyromonadaceae 976|Bacteroidetes C Aldo/keto reductase family - - - - - - - - - - - - Aldo_ket_red k59_1259736_1 485915.Dret_0324 1.65e-36 142.0 COG5009@1|root,COG5009@2|Bacteria,1MU5A@1224|Proteobacteria,42MJB@68525|delta/epsilon subdivisions,2WIXF@28221|Deltaproteobacteria,2M86M@213115|Desulfovibrionales 28221|Deltaproteobacteria M PFAM glycosyl transferase family 51 mrcA - 2.4.1.129,3.4.16.4 ko:K05366 ko00550,ko01100,ko01501,map00550,map01100,map01501 - - - ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 iAF987.Gmet_0354 PCB_OB,Transgly,Transpeptidase k59_808556_1 713587.THITH_07575 1.6e-84 277.0 28HY3@1|root,2Z83I@2|Bacteria,1R5P3@1224|Proteobacteria,1S1M3@1236|Gammaproteobacteria,1X028@135613|Chromatiales 135613|Chromatiales S phosphoenolpyruvate carboxykinase (diphosphate) activity - - 4.1.1.38 ko:K20370 ko00620,ko01100,map00620,map01100 - R00346 RC02741 ko00000,ko00001,ko01000 - - - - k59_808559_1 1122137.AQXF01000007_gene3579 5.86e-83 251.0 COG1028@1|root,COG1028@2|Bacteria,1MUBQ@1224|Proteobacteria,2TRPN@28211|Alphaproteobacteria 28211|Alphaproteobacteria IQ Belongs to the short-chain dehydrogenases reductases (SDR) family - - - - - - - - - - - - adh_short,adh_short_C2 k59_1373592_1 158500.BV97_01423 1.3e-87 265.0 COG1024@1|root,COG1024@2|Bacteria,1Q51H@1224|Proteobacteria,2TUPH@28211|Alphaproteobacteria,2K2FJ@204457|Sphingomonadales 204457|Sphingomonadales I Enoyl-CoA hydratase isomerase - - 4.2.1.17 ko:K01692 ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212 M00032,M00087 R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093 RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 - - - ECH_1 k59_1486821_1 316407.85675835 9.68e-18 79.7 COG1409@1|root,COG1409@2|Bacteria,1MWKX@1224|Proteobacteria,1RPA7@1236|Gammaproteobacteria,3XNUE@561|Escherichia 1236|Gammaproteobacteria S Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes cpdA GO:0003674,GO:0003824,GO:0004112,GO:0004114,GO:0004115,GO:0005488,GO:0005506,GO:0008081,GO:0008150,GO:0008198,GO:0009987,GO:0016043,GO:0016787,GO:0016788,GO:0042545,GO:0042578,GO:0043167,GO:0043169,GO:0045229,GO:0046872,GO:0046914,GO:0071554,GO:0071555,GO:0071840 3.1.4.53 ko:K03651 ko00230,ko02025,map00230,map02025 - R00191 RC00296 ko00000,ko00001,ko01000 - - - Metallophos k59_1486821_2 316407.85675834 8.6e-142 399.0 COG3150@1|root,COG3150@2|Bacteria,1MVJF@1224|Proteobacteria,1S5WF@1236|Gammaproteobacteria,3XN2H@561|Escherichia 1236|Gammaproteobacteria S Displays esterase activity toward palmitoyl-CoA and pNP- butyrate yqiA GO:0003674,GO:0003824,GO:0016787,GO:0016788 - ko:K07000 - - - - ko00000 - - - UPF0227 k59_1316938_1 1415778.JQMM01000001_gene868 6e-177 504.0 COG0773@1|root,COG0773@2|Bacteria,1MV68@1224|Proteobacteria,1RN88@1236|Gammaproteobacteria,1J4RF@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Belongs to the MurCDEF family murC GO:0000166,GO:0000270,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008763,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0017076,GO:0030203,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034645,GO:0035639,GO:0036094,GO:0042546,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0046872,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.3.2.8 ko:K01924 ko00471,ko00550,ko01100,map00471,map00550,map01100 - R03193 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - iECP_1309.ECP_0093 Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_356911_1 1238182.C882_2728 2.47e-14 71.6 COG3821@1|root,COG3821@2|Bacteria,1RDXR@1224|Proteobacteria,2TTTD@28211|Alphaproteobacteria,2JSCE@204441|Rhodospirillales 204441|Rhodospirillales S Protein of unknown function, DUF599 - - - - - - - - - - - - DUF599 k59_17351_2 1105367.CG50_05165 1.46e-06 52.0 COG1309@1|root,COG1309@2|Bacteria,1MZ9E@1224|Proteobacteria,2U0MU@28211|Alphaproteobacteria 28211|Alphaproteobacteria K transcriptional regulator acnR - - - - - - - - - - - TetR_C_7,TetR_N k59_1429238_2 644282.Deba_0178 9.04e-29 112.0 COG1595@1|root,COG1595@2|Bacteria,1MX7T@1224|Proteobacteria,42V72@68525|delta/epsilon subdivisions,2WRHE@28221|Deltaproteobacteria 28221|Deltaproteobacteria K Belongs to the sigma-70 factor family. ECF subfamily - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 k59_1768507_1 391615.ABSJ01000029_gene1955 5.01e-153 439.0 COG0137@1|root,COG0137@2|Bacteria,1MV0Y@1224|Proteobacteria,1RMEC@1236|Gammaproteobacteria,1J4BT@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Belongs to the argininosuccinate synthase family. Type 1 subfamily argG GO:0000050,GO:0000053,GO:0003674,GO:0003824,GO:0004055,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006575,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0019627,GO:0019752,GO:0034641,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:0072350,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 6.3.4.5 ko:K01940 ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418 M00029,M00844,M00845 R01954 RC00380,RC00629 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Arginosuc_synth k59_808578_1 1121912.AUHD01000017_gene3506 4.02e-71 231.0 COG0508@1|root,COG0508@2|Bacteria,4NFB9@976|Bacteroidetes,1HZ6M@117743|Flavobacteriia 976|Bacteroidetes C The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) pdhC - 2.3.1.12 ko:K00627 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200 M00307 R00209,R02569 RC00004,RC02742,RC02857 br01601,ko00000,ko00001,ko00002,ko01000 - - - 2-oxoacid_dh,Biotin_lipoyl,E3_binding k59_751457_1 1415754.JQMK01000012_gene969 3.27e-19 78.6 COG3791@1|root,COG3791@2|Bacteria 2|Bacteria S Glutathione-dependent formaldehyde-activating MA20_19505 - - - - - - - - - - - GFA k59_751457_2 247634.GPB2148_560 1.42e-44 147.0 COG3686@1|root,COG3686@2|Bacteria,1RAEH@1224|Proteobacteria,1SERR@1236|Gammaproteobacteria,1JA48@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S MAPEG family - - - - - - - - - - - - MAPEG k59_187189_1 1088721.NSU_3424 1.39e-63 210.0 COG0065@1|root,COG0065@2|Bacteria,1MVYR@1224|Proteobacteria,2TR6K@28211|Alphaproteobacteria,2K0IM@204457|Sphingomonadales 204457|Sphingomonadales E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate - - 4.2.1.33,4.2.1.35 ko:K01703 ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230 M00432,M00535 R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170 RC00497,RC00976,RC00977,RC01041,RC01046,RC03072 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase k59_468995_1 1192034.CAP_7003 7.36e-56 188.0 COG0626@1|root,COG0626@2|Bacteria,1MU57@1224|Proteobacteria,42M67@68525|delta/epsilon subdivisions,2WJQX@28221|Deltaproteobacteria 28221|Deltaproteobacteria E Cys Met metabolism - - 2.5.1.48,4.4.1.11,4.4.1.8 ko:K01739,ko:K01760,ko:K01761 ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00270,map00450,map00920,map01100,map01110,map01130,map01230 M00017 R00654,R00782,R00999,R01286,R01288,R02408,R02508,R03217,R03260,R04770,R04941,R04944,R04945,R04946 RC00020,RC00056,RC00069,RC00196,RC00348,RC00382,RC00420,RC00488,RC00710,RC01209,RC01210,RC01245,RC02303,RC02848,RC02866 ko00000,ko00001,ko00002,ko01000 - - - Cys_Met_Meta_PP k59_412591_1 1122137.AQXF01000007_gene3559 7.72e-111 328.0 COG0019@1|root,COG0019@2|Bacteria,1MZ7Y@1224|Proteobacteria,2TSKB@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Belongs to the Orn Lys Arg decarboxylase class-II family speF - 4.1.1.17 ko:K01581 ko00330,ko00480,ko01100,ko01110,ko01130,map00330,map00480,map01100,map01110,map01130 M00134 R00670 RC00299 ko00000,ko00001,ko00002,ko01000 - - - Orn_Arg_deC_N,Orn_DAP_Arg_deC k59_1203810_1 69395.JQLZ01000002_gene1449 2.38e-110 352.0 COG0145@1|root,COG0146@1|root,COG0145@2|Bacteria,COG0146@2|Bacteria,1MU2Y@1224|Proteobacteria,2TQZ6@28211|Alphaproteobacteria,2KFQR@204458|Caulobacterales 204458|Caulobacterales EQ Hydantoinase/oxoprolinase N-terminal region - - 3.5.2.9 ko:K01469 ko00480,map00480 - R00251 RC00553 ko00000,ko00001,ko01000 - - - Hydant_A_N,Hydantoinase_A,Hydantoinase_B k59_1768520_1 330214.NIDE4127 1.78e-134 401.0 COG1185@1|root,COG1185@2|Bacteria,3J0DX@40117|Nitrospirae 40117|Nitrospirae J Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction pnp - 2.7.7.8 ko:K00962 ko00230,ko00240,ko03018,map00230,map00240,map03018 M00394 R00437,R00438,R00439,R00440 RC02795 ko00000,ko00001,ko00002,ko01000,ko03016,ko03019 - - - KH_1,PNPase,RNase_PH,RNase_PH_C,S1 k59_695103_1 1382359.JIAL01000001_gene1987 1.84e-90 281.0 COG0516@1|root,COG0517@1|root,COG0516@2|Bacteria,COG0517@2|Bacteria,3Y2I9@57723|Acidobacteria,2JHNT@204432|Acidobacteriia 204432|Acidobacteriia F Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth guaB - 1.1.1.205 ko:K00088 ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 M00050 R01130,R08240 RC00143,RC02207 ko00000,ko00001,ko00002,ko01000,ko04147 - - - CBS,IMPDH k59_638650_1 1131553.JIBI01000003_gene1682 2.05e-10 60.5 COG2433@1|root,COG2433@2|Bacteria,1QWB7@1224|Proteobacteria,2WBIH@28216|Betaproteobacteria,37377@32003|Nitrosomonadales 28216|Betaproteobacteria S Bacterial SH3 domain homologues - - - ko:K07184 - - - - ko00000 - - - SH3_3 k59_638650_2 487316.BBNM01000001_gene1594 1.74e-105 328.0 COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MU0R@1224|Proteobacteria,1RP3T@1236|Gammaproteobacteria,3NJC4@468|Moraxellaceae 1236|Gammaproteobacteria G Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate ppsA GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006094,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008986,GO:0009058,GO:0009987,GO:0016051,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016781,GO:0019318,GO:0019319,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046364,GO:0046872,GO:0071704,GO:1901576 2.7.9.2 ko:K01007 ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200 M00173,M00374 R00199 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - iEcE24377_1341.EcE24377A_1919,iYL1228.KPN_02160 PEP-utilizers,PEP-utilizers_C,PPDK_N k59_976701_2 314287.GB2207_05422 5.39e-61 196.0 COG1737@1|root,COG1737@2|Bacteria,1MV3U@1224|Proteobacteria,1RNC4@1236|Gammaproteobacteria,1J615@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria K COG1737 Transcriptional regulators hexR GO:0000976,GO:0001067,GO:0001130,GO:0001131,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0006950,GO:0006974,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032991,GO:0032993,GO:0033554,GO:0043565,GO:0044212,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051716,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2001141 - ko:K19337 - - - - ko00000,ko03000 - - - HTH_6,SIS k59_976716_1 1242864.D187_003247 1.38e-41 150.0 COG0604@1|root,COG0604@2|Bacteria,1MW2V@1224|Proteobacteria 1224|Proteobacteria C COG0604 NADPH quinone reductase and related Zn-dependent oxidoreductases - - 1.6.5.5 ko:K00344 - - - - ko00000,ko01000 - - - ADH_N,ADH_zinc_N k59_976718_1 1411123.JQNH01000001_gene1877 5.65e-29 112.0 COG0604@1|root,COG0604@2|Bacteria,1MX8A@1224|Proteobacteria,2TR1J@28211|Alphaproteobacteria 28211|Alphaproteobacteria C COG0604 NADPH quinone reductase and related Zn-dependent oxidoreductases - - 1.6.5.5 ko:K00344 - - - - ko00000,ko01000 - - - ADH_N,ADH_zinc_N,ADH_zinc_N_2 k59_17389_1 1254432.SCE1572_24285 3.69e-35 141.0 COG0515@1|root,COG1366@1|root,COG2203@1|root,COG3899@1|root,COG0515@2|Bacteria,COG1366@2|Bacteria,COG2203@2|Bacteria,COG3899@2|Bacteria,1RGKE@1224|Proteobacteria,43DX3@68525|delta/epsilon subdivisions,2X71G@28221|Deltaproteobacteria 28221|Deltaproteobacteria KLT AAA ATPase domain - - - - - - - - - - - - AAA_16,GAF,GAF_2,HATPase_c,HisKA_3,Pkinase,STAS k59_130376_2 1463881.KL591035_gene4914 1.34e-08 55.1 2EH65@1|root,3351X@2|Bacteria,2GQUG@201174|Actinobacteria 201174|Actinobacteria S Domain of unknown function (DUF1876) - - - - - - - - - - - - DUF1876 k59_1768561_1 1137281.D778_00181 2.33e-138 425.0 COG0085@1|root,COG0085@2|Bacteria,4NF8D@976|Bacteroidetes,1HXXA@117743|Flavobacteriia 976|Bacteroidetes K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoB GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234 2.7.7.6 ko:K03043 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7 k59_808610_1 1229909.NSED_07510 2.3e-25 102.0 COG0473@1|root,arCOG01163@2157|Archaea,41S5U@651137|Thaumarchaeota 651137|Thaumarchaeota C Isocitrate isopropylmalate dehydrogenase - - 1.1.1.42 ko:K00031 ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146 M00009,M00010,M00173,M00740 R00267,R00268,R01899 RC00001,RC00084,RC00114,RC00626,RC02801 br01601,ko00000,ko00001,ko00002,ko01000 - - - Iso_dh k59_808610_2 436308.Nmar_1380 9.31e-84 251.0 COG2890@1|root,arCOG00109@2157|Archaea,41SSD@651137|Thaumarchaeota 651137|Thaumarchaeota Q Methyltransferase small domain - - 2.1.1.297 ko:K02493 - - R10806 RC00003,RC03279 ko00000,ko01000,ko03012 - - - MTS k59_311400_1 365046.Rta_05080 1.22e-05 52.4 COG4232@1|root,COG4233@1|root,COG4232@2|Bacteria,COG4233@2|Bacteria,1MU8W@1224|Proteobacteria,2VI8I@28216|Betaproteobacteria,4AA54@80864|Comamonadaceae 28216|Betaproteobacteria CO PFAM cytochrome c biogenesis protein, transmembrane region - - 1.8.1.8 ko:K04084,ko:K08344 - - - - ko00000,ko01000,ko02000,ko03110 5.A.1.1,5.A.1.5 - - DsbC,DsbD,Thioredoxin_7 k59_1046338_1 1178825.ALIH01000001_gene2381 4.64e-145 421.0 COG0423@1|root,COG0423@2|Bacteria,4NE1C@976|Bacteroidetes,1HX2K@117743|Flavobacteriia 976|Bacteroidetes J Belongs to the class-II aminoacyl-tRNA synthetase family glyQS - 6.1.1.14 ko:K01880 ko00970,map00970 M00359,M00360 R03654 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - HGTP_anticodon,tRNA-synt_2b k59_1665233_1 1088721.NSU_2668 4.42e-102 318.0 COG1251@1|root,COG1251@2|Bacteria,1MW58@1224|Proteobacteria,2TS8I@28211|Alphaproteobacteria,2K03B@204457|Sphingomonadales 204457|Sphingomonadales C Belongs to the nitrite and sulfite reductase 4Fe-4S domain family nirB - 1.7.1.15 ko:K00362 ko00910,ko01120,map00910,map01120 M00530 R00787 RC00176 ko00000,ko00001,ko00002,ko01000 - - - Fer2_BFD,NIR_SIR,NIR_SIR_ferr,Pyr_redox_2 k59_1384653_1 1122137.AQXF01000006_gene889 4.83e-208 581.0 COG0015@1|root,COG0015@2|Bacteria,1MV4B@1224|Proteobacteria,2TQUE@28211|Alphaproteobacteria 28211|Alphaproteobacteria F Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily purB GO:0003674,GO:0003824,GO:0004018,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016829,GO:0016840,GO:0016842,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046033,GO:0046390,GO:0046483,GO:0055086,GO:0070626,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.3.2.2 ko:K01756 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048,M00049 R01083,R04559 RC00379,RC00444,RC00445 ko00000,ko00001,ko00002,ko01000 - - - ADSL_C,Lyase_1 k59_1554730_1 1121937.AUHJ01000018_gene239 6.9e-26 105.0 COG3577@1|root,COG3577@2|Bacteria,1N2PE@1224|Proteobacteria,1S66F@1236|Gammaproteobacteria,467QR@72275|Alteromonadaceae 1236|Gammaproteobacteria S gag-polyprotein putative aspartyl protease - - - ko:K06985 ko04112,map04112 - - - ko00000,ko00001 - - - gag-asp_proteas k59_1554730_2 566466.NOR53_233 1.05e-60 192.0 COG1267@1|root,COG1267@2|Bacteria,1MZJA@1224|Proteobacteria,1S68A@1236|Gammaproteobacteria,1JA5X@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria I Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG) pgpA GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006629,GO:0006644,GO:0006650,GO:0006655,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0008962,GO:0009058,GO:0009987,GO:0010035,GO:0010038,GO:0016020,GO:0016021,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019637,GO:0030258,GO:0031224,GO:0031226,GO:0032026,GO:0042221,GO:0042577,GO:0042578,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044425,GO:0044459,GO:0044464,GO:0045017,GO:0046471,GO:0046474,GO:0046486,GO:0046839,GO:0050896,GO:0071704,GO:0071944,GO:0090407,GO:1901576 3.1.3.27 ko:K01095 ko00564,ko01100,map00564,map01100 - R02029 RC00017 ko00000,ko00001,ko01000 - - iECSP_1301.ECSP_0485,iECUMN_1333.ECUMN_0456,iECs_1301.ECs0471,iG2583_1286.G2583_0529,iPC815.YPO3179,iZ_1308.Z0520 PgpA k59_532984_1 1056820.KB900674_gene2523 6.86e-14 70.1 COG0209@1|root,COG0209@2|Bacteria,1P4EH@1224|Proteobacteria,1RP1A@1236|Gammaproteobacteria,2PQ1F@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria F TSCPD domain nrdJb - - - - - - - - - - - - k59_706201_1 1068978.AMETH_5249 1.33e-06 60.1 COG3629@1|root,COG3629@2|Bacteria,2I2QB@201174|Actinobacteria,4E8EJ@85010|Pseudonocardiales 201174|Actinobacteria K Bacterial transcriptional activator domain - - - - - - - - - - - - AAA_16,BTAD,Trans_reg_C k59_141134_3 391625.PPSIR1_01127 5.64e-49 171.0 COG5557@1|root,COG5557@2|Bacteria,1PFX4@1224|Proteobacteria,42PIE@68525|delta/epsilon subdivisions,2WM3C@28221|Deltaproteobacteria,2YU0I@29|Myxococcales 28221|Deltaproteobacteria C Polysulphide reductase, NrfD actC - - ko:K00185 - - - - ko00000 5.A.3 - - DUF3341,NrfD k59_706202_2 1517416.IDAT_07710 1.17e-67 216.0 COG0108@1|root,COG0807@1|root,COG0108@2|Bacteria,COG0807@2|Bacteria,1MU8P@1224|Proteobacteria,1RQ49@1236|Gammaproteobacteria,2QF12@267893|Idiomarinaceae 1236|Gammaproteobacteria H Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate ribB - 3.5.4.25,4.1.99.12 ko:K14652 ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110 M00125,M00840 R00425,R07281 RC00293,RC01792,RC01815,RC02504 ko00000,ko00001,ko00002,ko01000 - - - DHBP_synthase,GTP_cyclohydro2 k59_1325423_1 562970.Btus_0607 9.16e-25 108.0 COG0491@1|root,COG0607@1|root,COG0491@2|Bacteria,COG0607@2|Bacteria,1TPE2@1239|Firmicutes,4H9WH@91061|Bacilli,278QY@186823|Alicyclobacillaceae 91061|Bacilli P Rhodanese Homology Domain - - - - - - - - - - - - Lactamase_B,Rhodanese k59_1214521_1 349124.Hhal_0733 2e-37 145.0 COG3170@1|root,COG4313@1|root,COG3170@2|Bacteria,COG4313@2|Bacteria,1QUSB@1224|Proteobacteria,1T22F@1236|Gammaproteobacteria 1236|Gammaproteobacteria CNU Tfp pilus assembly protein FimV - - - - - - - - - - - - Phenol_MetA_deg k59_1268595_1 1380394.JADL01000011_gene4057 4.11e-72 227.0 COG3618@1|root,COG3618@2|Bacteria,1N2QM@1224|Proteobacteria,2TTZK@28211|Alphaproteobacteria,2JS33@204441|Rhodospirillales 204441|Rhodospirillales S Amidohydrolase - - - - - - - - - - - - Amidohydro_2 k59_706203_1 1122137.AQXF01000005_gene1313 7.11e-170 481.0 COG1960@1|root,COG1960@2|Bacteria,1MUK0@1224|Proteobacteria,2TSAC@28211|Alphaproteobacteria 28211|Alphaproteobacteria I acyl-CoA dehydrogenase - - 1.3.8.6 ko:K00252 ko00071,ko00310,ko00362,ko00380,ko01100,ko01120,ko01130,map00071,map00310,map00362,map00380,map01100,map01120,map01130 M00032 R02487,R02488,R10074 RC00052,RC00156 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_985386_1 396588.Tgr7_1164 2.96e-34 128.0 COG4589@1|root,COG4589@2|Bacteria,1R34Q@1224|Proteobacteria,1T63B@1236|Gammaproteobacteria,1WWNK@135613|Chromatiales 135613|Chromatiales S Belongs to the CDS family - - 2.7.7.41 ko:K00981 ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070 M00093 R01799 RC00002 ko00000,ko00001,ko00002,ko01000 - - - CTP_transf_1 k59_985386_2 768671.ThimaDRAFT_2153 7.43e-12 65.1 COG0743@1|root,COG0743@2|Bacteria,1MU4G@1224|Proteobacteria,1RNNW@1236|Gammaproteobacteria,1WX71@135613|Chromatiales 135613|Chromatiales I Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) dxr - 1.1.1.267 ko:K00099 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05688 RC01452 ko00000,ko00001,ko00002,ko01000 - - - DXPR_C,DXP_redisom_C,DXP_reductoisom k59_1665250_1 1282876.BAOK01000001_gene1269 2.34e-66 225.0 COG2304@1|root,COG2304@2|Bacteria,1MW8K@1224|Proteobacteria,2TV9Y@28211|Alphaproteobacteria 28211|Alphaproteobacteria S von Willebrand factor, type A - - - ko:K07114 - - - - ko00000,ko02000 1.A.13.2.2,1.A.13.2.3 - - VIT,VWA_3 k59_311444_1 1502850.FG91_01876 1.02e-67 222.0 COG2850@1|root,COG2850@2|Bacteria,1RDTN@1224|Proteobacteria,2U8MT@28211|Alphaproteobacteria,2K4YG@204457|Sphingomonadales 204457|Sphingomonadales S Cupin superfamily protein - - - - - - - - - - - - Cupin_8 k59_1498137_1 1197477.IA57_09205 1.44e-127 368.0 COG0190@1|root,COG0190@2|Bacteria,4NEJP@976|Bacteroidetes,1HY41@117743|Flavobacteriia 976|Bacteroidetes H Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate folD GO:0003674,GO:0003824,GO:0004477,GO:0004488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006730,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016645,GO:0016646,GO:0016787,GO:0016810,GO:0016814,GO:0019238,GO:0044237,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0055114 1.5.1.5,3.5.4.9 ko:K01491 ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200 M00140,M00377 R01220,R01655 RC00202,RC00578 ko00000,ko00001,ko00002,ko01000 - - - THF_DHG_CYH,THF_DHG_CYH_C k59_141143_1 685035.ADAE01000013_gene103 1.24e-87 268.0 COG3173@1|root,COG3173@2|Bacteria,1MWAK@1224|Proteobacteria,2TT2N@28211|Alphaproteobacteria,2K142@204457|Sphingomonadales 204457|Sphingomonadales S Aminoglycoside phosphotransferase - - - - - - - - - - - - APH k59_532997_1 1444711.CCJF01000003_gene91 1.22e-78 251.0 COG0058@1|root,COG0058@2|Bacteria,2JFEH@204428|Chlamydiae 204428|Chlamydiae G Carbohydrate phosphorylase glgP - 2.4.1.1 ko:K00688 ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931 - R02111 - ko00000,ko00001,ko01000 - GT35 - Phosphorylase k59_195989_1 926569.ANT_07770 3.07e-51 169.0 COG0171@1|root,COG0171@2|Bacteria,2G6X3@200795|Chloroflexi 200795|Chloroflexi H NAD synthase - - 6.3.1.5 ko:K01916 ko00760,ko01100,map00760,map01100 M00115 R00189 RC00100 ko00000,ko00001,ko00002,ko01000 - - - NAD_synthase k59_195989_2 661478.OP10G_1998 4.5e-12 66.2 COG0477@1|root,COG2814@2|Bacteria 2|Bacteria EGP Major facilitator Superfamily - - - - - - - - - - - - MFS_3 k59_368351_1 1408254.T458_08600 7.36e-15 80.1 COG0747@1|root,COG0747@2|Bacteria,1TQ6S@1239|Firmicutes,4HAM7@91061|Bacilli,26TIQ@186822|Paenibacillaceae 91061|Bacilli E ABC transporter substrate-binding protein - - - ko:K02035 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - SBP_bac_5 k59_1665257_1 639283.Snov_1504 1.06e-24 112.0 COG0389@1|root,COG0389@2|Bacteria,1MUUH@1224|Proteobacteria,2TSJN@28211|Alphaproteobacteria,3EYZR@335928|Xanthobacteraceae 28211|Alphaproteobacteria L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII dinB GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0050896,GO:0051716,GO:0071496 2.7.7.7 ko:K02346 - - - - ko00000,ko01000,ko03400 - - - IMS,IMS_C k59_141152_1 1144305.PMI02_00883 1.21e-90 270.0 COG0066@1|root,COG0066@2|Bacteria,1MVXB@1224|Proteobacteria,2VEQM@28211|Alphaproteobacteria,2K45W@204457|Sphingomonadales 204457|Sphingomonadales E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate - - 4.2.1.33,4.2.1.35 ko:K01704 ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230 M00432,M00535 R03896,R03898,R03968,R04001,R10170 RC00976,RC00977,RC01041,RC01046,RC03072 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase_C k59_1665258_1 1121374.KB891577_gene3164 2.63e-99 293.0 COG0807@1|root,COG0807@2|Bacteria,1MWZR@1224|Proteobacteria,1RMFX@1236|Gammaproteobacteria 1236|Gammaproteobacteria F Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate ribA GO:0003674,GO:0003824,GO:0003933,GO:0003935,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0017144,GO:0018130,GO:0019238,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 3.5.4.25 ko:K01497 ko00740,ko00790,ko01100,ko01110,ko02024,map00740,map00790,map01100,map01110,map02024 M00125 R00425 RC00293,RC02504 ko00000,ko00001,ko00002,ko01000 - - iAPECO1_1312.APECO1_437,iPC815.YPO2222,iSbBS512_1146.SbBS512_E1505,iUTI89_1310.UTI89_C1548 GTP_cyclohydro2 k59_1665258_2 998674.ATTE01000001_gene3584 1.01e-10 60.5 COG0107@1|root,COG0107@2|Bacteria,1MUS0@1224|Proteobacteria,1RPJQ@1236|Gammaproteobacteria,45ZVN@72273|Thiotrichales 72273|Thiotrichales E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit hisF - - ko:K02500 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04558 RC00010,RC01190,RC01943 ko00000,ko00001,ko00002,ko01000 - - - His_biosynth k59_85957_1 1246459.KB898353_gene411 1.47e-20 97.1 COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,2TQPZ@28211|Alphaproteobacteria,4BA3T@82115|Rhizobiaceae 28211|Alphaproteobacteria O Belongs to the peptidase S1C family degPch1 GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005575,GO:0005623,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0016787,GO:0017171,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043170,GO:0044238,GO:0044464,GO:0070011,GO:0071704,GO:0140096,GO:1901564 3.4.21.107 ko:K04771 ko01503,ko02020,map01503,map02020 M00728 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 - - - PDZ_2,Trypsin_2 k59_533007_1 82996.sch_02610 9.76e-68 218.0 COG0270@1|root,COG0270@2|Bacteria,1MV9H@1224|Proteobacteria,1S054@1236|Gammaproteobacteria,403XF@613|Serratia 1236|Gammaproteobacteria L C-5 cytosine-specific DNA methylase - - 2.1.1.37 ko:K00558 ko00270,ko01100,ko05206,map00270,map01100,map05206 M00035 R04858 RC00003,RC00332 ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036 - - - DNA_methylase k59_533007_2 1280953.HOC_04779 7.33e-08 52.8 COG1396@1|root,COG1396@2|Bacteria,1NE5F@1224|Proteobacteria,2UGAF@28211|Alphaproteobacteria 28211|Alphaproteobacteria K Helix-turn-helix - - - - - - - - - - - - HTH_3,HTH_31 k59_592942_1 1229909.NSED_01660 4.69e-35 129.0 arCOG08643@1|root,arCOG08716@1|root,arCOG08643@2157|Archaea,arCOG08716@2157|Archaea,41T3H@651137|Thaumarchaeota 651137|Thaumarchaeota S peptidyl-tyrosine sulfation - - - - - - - - - - - - - k59_592942_2 1229909.NSED_01665 1.3e-51 163.0 COG2012@1|root,arCOG04258@2157|Archaea,41SU8@651137|Thaumarchaeota 651137|Thaumarchaeota K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoH - 2.7.7.6 ko:K03053 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00184 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021 - - - RNA_pol_Rpb5_C k59_592942_3 1229909.NSED_01670 3.05e-16 77.0 COG0085@1|root,arCOG01762@2157|Archaea,41SF5@651137|Thaumarchaeota 651137|Thaumarchaeota K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates - - 2.7.7.6 ko:K13798 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00184 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021 - - - RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_4,RNA_pol_Rpb2_5,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7 k59_759904_1 317025.Tcr_0338 6.12e-55 186.0 COG1680@1|root,COG1680@2|Bacteria,1P3SQ@1224|Proteobacteria,1RRMI@1236|Gammaproteobacteria,462ZC@72273|Thiotrichales 72273|Thiotrichales V Beta-lactamase - - - - - - - - - - - - Beta-lactamase k59_929661_1 1278073.MYSTI_07874 8.63e-40 151.0 COG3391@1|root,COG3391@2|Bacteria,1R66T@1224|Proteobacteria,439FZ@68525|delta/epsilon subdivisions,2X4RS@28221|Deltaproteobacteria,2YZGC@29|Myxococcales 28221|Deltaproteobacteria G 6-phosphogluconolactonase activity - - - - - - - - - - - - - k59_477631_1 1284679.HMPREF1626_08160 3.45e-35 132.0 COG2267@1|root,COG2267@2|Bacteria,2GPA8@201174|Actinobacteria,4D3AJ@85005|Actinomycetales 201174|Actinobacteria I Hydrolase, alpha beta domain protein - - - - - - - - - - - - Hydrolase_4 k59_477631_2 382464.ABSI01000013_gene1650 4.37e-21 95.1 COG4206@1|root,COG4206@2|Bacteria 2|Bacteria H cobalamin-transporting ATPase activity - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_28894_2 1151122.AQYD01000007_gene963 3.11e-09 58.5 COG1028@1|root,COG1028@2|Bacteria,2GJQC@201174|Actinobacteria 201174|Actinobacteria IQ KR domain - - - - - - - - - - - - adh_short_C2 k59_28894_3 1144305.PMI02_00671 1.12e-05 46.6 COG2124@1|root,COG2124@2|Bacteria,1R599@1224|Proteobacteria,2U0QG@28211|Alphaproteobacteria 28211|Alphaproteobacteria Q cytochrome P-450 CYP112A - - ko:K21116 - - - - ko00000,ko00199 - - - p450 k59_1384728_1 365046.Rta_05920 3.23e-74 234.0 COG2084@1|root,COG2084@2|Bacteria,1RBRD@1224|Proteobacteria,2VX25@28216|Betaproteobacteria,4AHH5@80864|Comamonadaceae 28216|Betaproteobacteria I NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase - - 1.1.1.31 ko:K00020 ko00280,ko01100,map00280,map01100 - R05066 RC00099 ko00000,ko00001,ko01000 - - - NAD_binding_11,NAD_binding_2 k59_422061_1 258052.JNYV01000005_gene2351 3.28e-43 150.0 COG0020@1|root,COG0020@2|Bacteria,2GIXF@201174|Actinobacteria,2M18G@2063|Kitasatospora 201174|Actinobacteria I Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids uppS GO:0000287,GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006066,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008834,GO:0009058,GO:0009987,GO:0016020,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0030145,GO:0033850,GO:0040007,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0046872,GO:0046914,GO:0050347,GO:0071704,GO:0071944,GO:1901576,GO:1901615,GO:1901617 2.5.1.31,2.5.1.86,2.5.1.88 ko:K00806,ko:K14215,ko:K21273 ko00900,ko01110,map00900,map01110 - R06447,R09244,R09731 RC00279,RC02839 ko00000,ko00001,ko01000,ko01006 - - - Prenyltransf k59_1046441_1 880072.Desac_2719 2.47e-37 145.0 COG4775@1|root,COG4775@2|Bacteria,1MU0D@1224|Proteobacteria,42MMA@68525|delta/epsilon subdivisions,2WIZB@28221|Deltaproteobacteria,2MQA8@213462|Syntrophobacterales 28221|Deltaproteobacteria M Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane bamA - - ko:K07277 - - - - ko00000,ko02000,ko03029 1.B.33 - - Bac_surface_Ag,POTRA k59_196041_1 436308.Nmar_0543 6.32e-117 345.0 COG0422@1|root,arCOG02741@2157|Archaea,41S5Z@651137|Thaumarchaeota 651137|Thaumarchaeota H Thiamine biosynthesis protein ThiC - - 4.1.99.17 ko:K03147 ko00730,ko01100,map00730,map01100 M00127 R03472 RC03251,RC03252 ko00000,ko00001,ko00002,ko01000 - - - ThiC_Rad_SAM k59_196041_2 436308.Nmar_0544 1.44e-63 196.0 COG1184@1|root,arCOG01127@2157|Archaea,41T2Z@651137|Thaumarchaeota 651137|Thaumarchaeota L NUDIX domain - - - - - - - - - - - - NUDIX k59_253690_1 517418.Ctha_1497 2.39e-11 66.2 COG1403@1|root,COG1403@2|Bacteria,1FDXZ@1090|Chlorobi 1090|Chlorobi L PFAM HNH endonuclease - - - - - - - - - - - - HNH,HNH_5 k59_28914_1 485913.Krac_11275 2.73e-74 234.0 COG4956@1|root,COG4956@2|Bacteria,2G5YK@200795|Chloroflexi 200795|Chloroflexi S SMART Nucleotide binding protein, PINc - - - - - - - - - - - - TRAM k59_311517_1 269796.Rru_A1213 7.66e-115 360.0 COG0567@1|root,COG0567@2|Bacteria,1MVBF@1224|Proteobacteria,2TRBQ@28211|Alphaproteobacteria,2JPTT@204441|Rhodospirillales 204441|Rhodospirillales C COG0567 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes sucA - 1.2.4.2 ko:K00164 ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00032 R00621,R01933,R01940,R03316,R08549 RC00004,RC00027,RC00627,RC02743,RC02833,RC02883 br01601,ko00000,ko00001,ko00002,ko01000 - - - 2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr k59_1437938_1 1088721.NSU_0610 5.96e-114 337.0 COG0104@1|root,COG0104@2|Bacteria,1MU5B@1224|Proteobacteria,2TRKY@28211|Alphaproteobacteria,2K0T7@204457|Sphingomonadales 204457|Sphingomonadales F Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP purA - 6.3.4.4 ko:K01939 ko00230,ko00250,ko01100,map00230,map00250,map01100 M00049 R01135 RC00458,RC00459 ko00000,ko00001,ko00002,ko01000 - - - Adenylsucc_synt k59_253697_2 225937.HP15_2125 4.41e-97 287.0 COG3647@1|root,COG3647@2|Bacteria,1N7NB@1224|Proteobacteria,1S6G7@1236|Gammaproteobacteria,468G7@72275|Alteromonadaceae 1236|Gammaproteobacteria S Predicted membrane protein (DUF2238) yjdF - - ko:K08984 - - - - ko00000 - - - DUF2238 k59_1554841_1 1278073.MYSTI_05230 5.07e-31 122.0 COG0416@1|root,COG0416@2|Bacteria,1MVM3@1224|Proteobacteria,42NRV@68525|delta/epsilon subdivisions,2WIXX@28221|Deltaproteobacteria,2YYV1@29|Myxococcales 28221|Deltaproteobacteria I Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA plsX - 2.3.1.15 ko:K03621 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R00851,R09380 RC00004,RC00039,RC00041 ko00000,ko00001,ko00002,ko01000,ko01004 - - - FA_synthesis k59_1665305_2 627192.SLG_12450 5.41e-69 211.0 COG0824@1|root,COG0824@2|Bacteria,1Q4WD@1224|Proteobacteria,2UD52@28211|Alphaproteobacteria,2KAAB@204457|Sphingomonadales 204457|Sphingomonadales S Thioesterase superfamily - - 3.1.2.23 ko:K01075 ko00130,ko00362,ko01100,ko01110,ko01120,map00130,map00362,map01100,map01110,map01120 - R01301 RC00004,RC00174 ko00000,ko00001,ko01000 - - - 4HBT k59_1665305_3 702113.PP1Y_AT11631 4.26e-43 150.0 2BNU4@1|root,32HHX@2|Bacteria,1NQV4@1224|Proteobacteria,2VD3V@28211|Alphaproteobacteria,2K9PS@204457|Sphingomonadales 204457|Sphingomonadales - - - - - - - - - - - - - - - k59_759940_1 762903.Pedsa_3753 0.000983 48.1 COG4733@1|root,COG4733@2|Bacteria,4NINK@976|Bacteroidetes,1IX3J@117747|Sphingobacteriia 976|Bacteroidetes S SPTR GPI anchored protein - - - - - - - - - - - - Alginate_lyase,Laminin_G_3 k59_141203_1 436308.Nmar_1578 5.04e-225 635.0 COG1001@1|root,arCOG00693@2157|Archaea,41SZH@651137|Thaumarchaeota 651137|Thaumarchaeota F Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family ade - 3.5.4.2 ko:K01486 ko00230,ko01100,map00230,map01100 - R01244 RC00477 ko00000,ko00001,ko01000 - - - Adenine_deam_C,Amidohydro_1 k59_1099617_1 1193181.BN10_520008 4.58e-55 196.0 COG2902@1|root,COG2902@2|Bacteria,2GK0C@201174|Actinobacteria,4FG36@85021|Intrasporangiaceae 201174|Actinobacteria E Dehydrogenase gdh - 1.4.1.2 ko:K15371 ko00220,ko00250,ko00430,ko00910,ko01100,map00220,map00250,map00430,map00910,map01100 - R00243 RC00006,RC02799 ko00000,ko00001,ko01000 - - - Bac_GDH k59_28940_1 1096930.L284_16505 3.93e-249 694.0 COG1960@1|root,COG1960@2|Bacteria,1MU20@1224|Proteobacteria,2TQJS@28211|Alphaproteobacteria,2K0RG@204457|Sphingomonadales 204457|Sphingomonadales I acyl-CoA dehydrogenase - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_C,Acyl-CoA_dh_M,Acyl-CoA_dh_N,AcylCoA_DH_N k59_1610614_1 323848.Nmul_A2748 1.44e-27 107.0 COG0767@1|root,COG0767@2|Bacteria,1MVPN@1224|Proteobacteria,2VI5T@28216|Betaproteobacteria,3728G@32003|Nitrosomonadales 28216|Betaproteobacteria Q Permease MlaE ttg2B - - ko:K02066 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - MlaE k59_1610614_2 1485544.JQKP01000001_gene1099 6.24e-46 155.0 COG1127@1|root,COG1127@2|Bacteria,1MUSD@1224|Proteobacteria,2VJIA@28216|Betaproteobacteria,44VBC@713636|Nitrosomonadales 28216|Betaproteobacteria Q ABC transporter ttg2A - - ko:K02065 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - ABC_tran k59_1384793_1 1120705.FG95_01171 3.96e-71 231.0 COG0665@1|root,COG0665@2|Bacteria,1MU40@1224|Proteobacteria,2TTKE@28211|Alphaproteobacteria,2JZZ7@204457|Sphingomonadales 204457|Sphingomonadales E Tryptophan halogenase - - 1.14.19.9 ko:K14266 ko00404,ko01130,map00404,map01130 M00789,M00790 R09570 RC00949 ko00000,ko00001,ko00002,ko01000 - - - Trp_halogenase k59_929709_1 1122137.AQXF01000002_gene555 4.26e-29 114.0 COG0477@1|root,COG2814@2|Bacteria,1R44K@1224|Proteobacteria 1224|Proteobacteria EGP Transmembrane secretion effector - - - - - - - - - - - - MFS_1 k59_929709_2 1122604.JONR01000039_gene3785 2.39e-37 135.0 COG1695@1|root,COG1695@2|Bacteria,1NKS4@1224|Proteobacteria 1224|Proteobacteria K Transcriptional regulator PadR-like family - - - - - - - - - - - - PadR k59_929709_3 1123060.JONP01000006_gene4783 8.3e-19 84.7 COG0454@1|root,COG0456@2|Bacteria,1N81E@1224|Proteobacteria,2UA5A@28211|Alphaproteobacteria 28211|Alphaproteobacteria K Acetyltransferase GNAT family - - - - - - - - - - - - Acetyltransf_1 k59_369510_2 1122137.AQXF01000002_gene174 2.54e-44 148.0 COG1546@1|root,COG1546@2|Bacteria,1RH2Y@1224|Proteobacteria,2U94H@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Belongs to the CinA family cinA - 3.5.1.42 ko:K03743 ko00760,map00760 - R02322 RC00100 ko00000,ko00001,ko01000 - - - CinA k59_1438780_1 1220535.IMCC14465_09180 8.68e-32 124.0 COG0760@1|root,COG0760@2|Bacteria,1R4ZR@1224|Proteobacteria,2U874@28211|Alphaproteobacteria,4BSQC@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria O PPIC-type PPIASE domain - - 5.2.1.8 ko:K03769 - - - - ko00000,ko01000,ko03110 - - - Rotamase_2 k59_817484_1 1197477.IA57_00955 1.11e-87 261.0 28J86@1|root,2Z93E@2|Bacteria,4NJYR@976|Bacteroidetes,1I0EG@117743|Flavobacteriia 976|Bacteroidetes S membrane - - - - - - - - - - - - - k59_986294_1 697284.ERIC2_c01250 7.77e-10 61.2 COG4992@1|root,COG4992@2|Bacteria,1TP9S@1239|Firmicutes,4H9VZ@91061|Bacilli,26R2D@186822|Paenibacillaceae 91061|Bacilli E acetylornithine aminotransferase argD GO:0003674,GO:0003824,GO:0003992,GO:0005488,GO:0005515,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0019752,GO:0019842,GO:0030170,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.6.1.11,2.6.1.17 ko:K00821 ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00028,M00845 R02283,R04475 RC00006,RC00062 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 k59_986294_2 35720.XP_003648793.1 2.01e-10 62.0 KOG1681@1|root,KOG1681@2759|Eukaryota,38TRP@33154|Opisthokonta,3NU5A@4751|Fungi,3QKYA@4890|Ascomycota,2124G@147550|Sordariomycetes,3U545@5139|Sordariales,3HC8A@35718|Chaetomiaceae 4751|Fungi I Enoyl-CoA hydratase/isomerase - - - ko:K12663 ko04146,map04146 - - - ko00000,ko00001,ko01000 - - - ECH_1 k59_648118_1 1122137.AQXF01000002_gene597 2.95e-121 367.0 COG0188@1|root,COG0188@2|Bacteria,1MURI@1224|Proteobacteria,2TQRQ@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule parC - - ko:K02621 - - - - ko00000,ko01000,ko02048,ko03032,ko03036 - - - DNA_gyraseA_C,DNA_topoisoIV k59_707396_1 1280949.HAD_04450 3.49e-141 412.0 COG1626@1|root,COG1626@2|Bacteria,1MWSM@1224|Proteobacteria,2TUAI@28211|Alphaproteobacteria 28211|Alphaproteobacteria G Trehalase treA - 3.2.1.28 ko:K01194 ko00500,ko01100,map00500,map01100 - R00010 RC00049 ko00000,ko00001,ko00537,ko01000 - GH37 - Trehalase k59_1277155_1 1437425.CSEC_0291 1.67e-43 156.0 COG3424@1|root,COG3424@2|Bacteria,2JH9N@204428|Chlamydiae 204428|Chlamydiae Q FAE1/Type III polyketide synthase-like protein - - - - - - - - - - - - Chal_sti_synt_C,Chal_sti_synt_N k59_207433_1 876044.IMCC3088_1281 4.7e-210 605.0 COG0058@1|root,COG0058@2|Bacteria,1MW4J@1224|Proteobacteria,1RN8P@1236|Gammaproteobacteria 1236|Gammaproteobacteria G Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties glgP - 2.4.1.1 ko:K00688 ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931 - R02111 - ko00000,ko00001,ko01000 - GT35 - Phosphorylase k59_887921_1 1122225.AULQ01000006_gene1034 1.69e-74 244.0 COG1472@1|root,COG1472@2|Bacteria,4NE90@976|Bacteroidetes,1HX27@117743|Flavobacteriia 976|Bacteroidetes G Belongs to the glycosyl hydrolase 3 family - - 3.2.1.21 ko:K05349 ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110 - R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040 RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248 ko00000,ko00001,ko01000 - GH3 - Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C k59_39864_1 702113.PP1Y_AT25700 3.66e-17 80.5 COG3152@1|root,COG3152@2|Bacteria,1QSGM@1224|Proteobacteria,2V1EX@28211|Alphaproteobacteria,2KBGC@204457|Sphingomonadales 204457|Sphingomonadales S Protein of unknown function (DUF805) - - - - - - - - - - - - DUF805 k59_39868_1 1288826.MSNKSG1_14347 5.13e-132 380.0 COG0388@1|root,COG0388@2|Bacteria,1MY3W@1224|Proteobacteria,1RY6Z@1236|Gammaproteobacteria,465SH@72275|Alteromonadaceae 1236|Gammaproteobacteria S Also exhibits in vitro acyl transferase activity, transferring the acyl moiety of short-chain amides to hydroxylamine to form hydroxamates amiE - 3.5.1.4 ko:K01426 ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120 - R02540,R03096,R03180,R03909,R05551,R05590 RC00010,RC00100,RC00950,RC01025 ko00000,ko00001,ko01000 - - - CN_hydrolase k59_95511_1 555793.WSK_3367 5.9e-82 271.0 COG0457@1|root,COG5010@1|root,COG0457@2|Bacteria,COG5010@2|Bacteria,1MVB8@1224|Proteobacteria,2U28P@28211|Alphaproteobacteria,2K2RP@204457|Sphingomonadales 204457|Sphingomonadales U PFAM Cellulose synthase operon - - - ko:K20543 - - - - ko00000,ko02000 1.B.55.3 - - BCSC_C,TPR_16,TPR_19 k59_1108621_1 436308.Nmar_0311 6.57e-118 354.0 COG0008@1|root,arCOG04302@2157|Archaea,41S5V@651137|Thaumarchaeota 651137|Thaumarchaeota J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) gltX - 6.1.1.17 ko:K01885 ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120 M00121,M00359,M00360 R05578 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016 - - - tRNA-synt_1c,tRNA-synt_1c_C k59_149953_1 69395.JQLZ01000002_gene1324 2.96e-61 207.0 COG3507@1|root,COG3507@2|Bacteria,1NNX4@1224|Proteobacteria,2U06C@28211|Alphaproteobacteria,2KHNU@204458|Caulobacterales 204458|Caulobacterales G Belongs to the glycosyl hydrolase 43 family - - 3.2.1.37 ko:K01198 ko00520,ko01100,map00520,map01100 - R01433 RC00467 ko00000,ko00001,ko01000 - GH43 - Glyco_hydro_43 k59_430677_1 929556.Solca_3765 3.93e-35 132.0 COG2704@1|root,COG2704@2|Bacteria,4NGDF@976|Bacteroidetes,1IRQ7@117747|Sphingobacteriia 976|Bacteroidetes S PFAM Anaerobic c4-dicarboxylate membrane transporter - - - ko:K07791 - - - - ko00000,ko02000 2.A.13.1 - - DcuA_DcuB k59_717785_1 1229909.NSED_05525 6.39e-117 342.0 COG1708@1|root,arCOG01201@2157|Archaea 2157|Archaea S nucleotidyltransferase activity - - - ko:K07076 - - - - ko00000 - - - NTP_transf_2 k59_604670_2 1449049.JONW01000009_gene4292 5.44e-61 201.0 COG3000@1|root,COG3000@2|Bacteria,1RI5I@1224|Proteobacteria,2UAGB@28211|Alphaproteobacteria 28211|Alphaproteobacteria I Fatty acid hydroxylase superfamily - - - - - - - - - - - - FA_hydroxylase k59_604670_3 1161401.ASJA01000014_gene1075 6.78e-29 114.0 COG2207@1|root,COG2207@2|Bacteria,1P4M5@1224|Proteobacteria,2U37A@28211|Alphaproteobacteria 28211|Alphaproteobacteria K helix_turn_helix, arabinose operon control protein - - - - - - - - - - - - HTH_18 k59_39873_1 502025.Hoch_2100 2.57e-47 179.0 COG4770@1|root,COG4799@1|root,COG4770@2|Bacteria,COG4799@2|Bacteria,1P6RE@1224|Proteobacteria,43A2M@68525|delta/epsilon subdivisions,2X1XW@28221|Deltaproteobacteria,2YX2T@29|Myxococcales 28221|Deltaproteobacteria I Acetyl-CoA carboxylase, central region - - - - - - - - - - - - ACC_central,Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2,Carboxyl_trans k59_323190_1 443152.MDG893_08110 7.38e-56 197.0 COG5000@1|root,COG5001@1|root,COG5000@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,465EN@72275|Alteromonadaceae 1236|Gammaproteobacteria T signal transduction protein containing a membrane domain, an EAL and a GGDEF domain - - 2.1.1.80,3.1.1.61 ko:K13924 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko02022,ko02035 - - - CHASE5,CheB_methylest,CheR,CheR_N,EAL,GGDEF,PAS_4,PAS_9,Response_reg k59_1396119_1 649638.Trad_0091 7.82e-18 85.1 COG1309@1|root,COG1309@2|Bacteria,1WKU5@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus K Bacterial regulatory proteins, tetR family - - - - - - - - - - - - TetR_N k59_1277188_1 745718.JADT01000013_gene1277 2.09e-193 543.0 COG0304@1|root,COG0304@2|Bacteria,4NEKC@976|Bacteroidetes,1HWXE@117743|Flavobacteriia 976|Bacteroidetes I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP fabF - 2.3.1.179 ko:K09458 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119 RC00039,RC02728,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Ketoacyl-synt_C,ketoacyl-synt k59_379523_1 5911.EAR99658 8.91e-08 61.2 COG2074@1|root,2QR37@2759|Eukaryota,3ZBWF@5878|Ciliophora 5878|Ciliophora G myo-inositol hexakisphosphate metabolic process - - - ko:K05715 - - R02664 RC00002,RC00017 ko00000,ko01000 - - - - k59_379523_2 1158760.AQXP01000033_gene974 2.58e-27 112.0 COG4783@1|root,COG4783@2|Bacteria,1MVFV@1224|Proteobacteria,1RP5S@1236|Gammaproteobacteria,1WWCN@135613|Chromatiales 135613|Chromatiales S Functions as both a chaperone and a metalloprotease. Maintains the integrity of the outer membrane by promoting either the assembly or the elimination of outer membrane proteins, depending on their folding state - - - - - - - - - - - - Peptidase_M48 k59_1108629_1 243231.GSU3024 4.61e-23 107.0 COG4641@1|root,COG4641@2|Bacteria,1R64N@1224|Proteobacteria,42N73@68525|delta/epsilon subdivisions,2WM84@28221|Deltaproteobacteria 28221|Deltaproteobacteria S DUF based on E. rectale Gene description (DUF3880) - - - ko:K06320 - - - - ko00000 - - - DUF3880,Glyco_trans_1_2 k59_1108631_1 76869.PputGB1_1472 6.28e-45 153.0 COG3216@1|root,COG3216@2|Bacteria,1RGV6@1224|Proteobacteria,1S682@1236|Gammaproteobacteria 1236|Gammaproteobacteria S protein conserved in bacteria TLL0138 - - ko:K09928 - - - - ko00000 - - - DUF2062 k59_939015_1 436308.Nmar_0380 3.77e-94 285.0 arCOG10517@1|root,arCOG10517@2157|Archaea,41T0I@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_768815_1 583355.Caka_0064 5.23e-108 336.0 COG0243@1|root,COG0243@2|Bacteria 2|Bacteria C molybdopterin cofactor binding napA GO:0003674,GO:0003824,GO:0003954,GO:0005488,GO:0005575,GO:0005623,GO:0006091,GO:0008150,GO:0008152,GO:0008940,GO:0009061,GO:0009325,GO:0009987,GO:0015980,GO:0016491,GO:0016651,GO:0016661,GO:0030151,GO:0030288,GO:0030313,GO:0031975,GO:0032991,GO:0042597,GO:0043167,GO:0043169,GO:0044237,GO:0044464,GO:0045333,GO:0046872,GO:0046914,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:1902494 - ko:K02567 ko00910,ko01120,map00910,map01120 M00529,M00530 R00798,R01106 RC02812 ko00000,ko00001,ko00002,ko01000 - - iEC042_1314.EC042_2447,iECABU_c1320.ECABU_c25400,iECO103_1326.ECO103_2681,iECSE_1348.ECSE_2474,iECSF_1327.ECSF_2087,iECUMN_1333.ECUMN_2541,iEcHS_1320.EcHS_A2344,iEcolC_1368.EcolC_1444,iPC815.YPO3038,iSSON_1240.SSON_2264,ic_1306.c2745 Molybdop_Fe4S4,Molybdopterin,Molydop_binding,TAT_signal k59_604720_1 420662.Mpe_A1273 1.02e-49 169.0 COG0573@1|root,COG0573@2|Bacteria,1MVKP@1224|Proteobacteria,2VH4G@28216|Betaproteobacteria,1KJ4T@119065|unclassified Burkholderiales 28216|Betaproteobacteria P probably responsible for the translocation of the substrate across the membrane pstC - - ko:K02037 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - BPD_transp_1 k59_768824_1 1174684.EBMC1_15759 1.03e-42 144.0 COG1187@1|root,COG1187@2|Bacteria,1R9VV@1224|Proteobacteria,2U5H3@28211|Alphaproteobacteria,2K0BZ@204457|Sphingomonadales 204457|Sphingomonadales J Belongs to the pseudouridine synthase RsuA family rluE - 5.4.99.20 ko:K06181 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2 k59_768824_2 1192759.AKIB01000017_gene1785 2.36e-90 267.0 2AIH5@1|root,318Z0@2|Bacteria,1NQHR@1224|Proteobacteria,2UPIQ@28211|Alphaproteobacteria,2K8TG@204457|Sphingomonadales 204457|Sphingomonadales S Protein of unknown function (DUF3237) - - - - - - - - - - - - DUF3237 k59_768824_3 1500897.JQNA01000001_gene5383 1.53e-10 61.2 COG1028@1|root,COG1028@2|Bacteria,1MXNY@1224|Proteobacteria,2VN50@28216|Betaproteobacteria,1K3D6@119060|Burkholderiaceae 28216|Betaproteobacteria IQ Short-chain dehydrogenase reductase sdr - - - - - - - - - - - - adh_short_C2 k59_768832_1 558173.CDOO_03265 2.81e-11 69.7 COG0389@1|root,COG0389@2|Bacteria,2GMZ3@201174|Actinobacteria,22KH4@1653|Corynebacteriaceae 201174|Actinobacteria L DNA polymerase involved in DNA repair dinB_2 - - ko:K14161 - - - - ko00000,ko03400 - - - IMS k59_1447609_1 243090.RB5028 1.92e-30 125.0 COG0470@1|root,COG0515@1|root,COG1262@1|root,COG0470@2|Bacteria,COG0515@2|Bacteria,COG1262@2|Bacteria,2IY3E@203682|Planctomycetes 203682|Planctomycetes KLT Sulfatase-modifying factor enzyme 1 - - - - - - - - - - - - FGE-sulfatase,Pkinase k59_1447609_2 330214.NIDE1528 1.27e-06 53.5 COG1716@1|root,COG1716@2|Bacteria 2|Bacteria T histone H2A K63-linked ubiquitination - - - - - - - - - - - - DUF4388,FHA,Yop-YscD_cpl k59_1447609_3 1128912.GMES_3147 5.82e-09 55.8 COG2837@1|root,COG2837@2|Bacteria,1MXKF@1224|Proteobacteria,1S153@1236|Gammaproteobacteria,46B7I@72275|Alteromonadaceae 1236|Gammaproteobacteria P peroxidase - - - - - - - - - - - - Dyp_perox k59_1277244_1 622637.KE124774_gene3535 8.21e-48 164.0 COG2801@1|root,COG2801@2|Bacteria,1P5SB@1224|Proteobacteria,2U24Y@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Integrase - - - - - - - - - - - - HTH_32,rve,rve_3 k59_604734_1 743720.Psefu_0045 1.05e-46 162.0 COG1652@1|root,COG1652@2|Bacteria,1MUBV@1224|Proteobacteria,1RPMB@1236|Gammaproteobacteria 1236|Gammaproteobacteria C protein containing LysM domain lysM - - - - - - - - - - - LysM k59_95570_1 43354.JOIJ01000002_gene4541 1.09e-84 263.0 COG0160@1|root,COG0160@2|Bacteria,2GKVH@201174|Actinobacteria,4DZMQ@85010|Pseudonocardiales 201174|Actinobacteria E Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family - - 1.2.1.18,1.2.1.27,2.6.1.19 ko:K00140,ko:K00823 ko00250,ko00280,ko00410,ko00562,ko00640,ko00650,ko01100,ko01120,ko01200,map00250,map00280,map00410,map00562,map00640,map00650,map01100,map01120,map01200 M00013,M00027 R00705,R00706,R00908,R00922,R00935,R01648 RC00004,RC00006,RC00062,RC02723,RC02817 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 k59_379569_1 316407.85677018 1.36e-77 232.0 COG2963@1|root,COG2963@2|Bacteria,1RCDZ@1224|Proteobacteria,1S1YS@1236|Gammaproteobacteria,3XQYY@561|Escherichia 1236|Gammaproteobacteria L Transposase insC for insertion element IS2A D F H I K - - - ko:K07483 - - - - ko00000 - - - HTH_Tnp_1 k59_379569_2 511145.b4273 1.39e-228 628.0 COG2801@1|root,COG2801@2|Bacteria,1MY62@1224|Proteobacteria,1RQSR@1236|Gammaproteobacteria,3XQHU@561|Escherichia 1236|Gammaproteobacteria L DNA integration - GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576 - ko:K07497 - - - - ko00000 - - - HTH_21,rve k59_95577_1 1121382.JQKG01000004_gene4079 1.96e-63 208.0 COG1653@1|root,COG1653@2|Bacteria,1WJE6@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus G Bacterial extracellular solute-binding protein - - - ko:K10227 ko02010,map02010 M00200 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1.5 - - SBP_bac_1 k59_1447619_1 1165841.SULAR_03817 3.01e-44 163.0 COG0204@1|root,COG0318@1|root,COG0204@2|Bacteria,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,42M5F@68525|delta/epsilon subdivisions,2YTAQ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria IQ PFAM AMP-dependent synthetase and ligase - - 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding k59_264790_1 379066.GAU_0614 2.54e-35 130.0 COG0546@1|root,COG0546@2|Bacteria,1ZTK9@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Haloacid dehalogenase-like hydrolase - - - - - - - - - - - - HAD k59_1168068_1 344747.PM8797T_02909 2.02e-19 98.2 COG0642@1|root,COG1352@1|root,COG2202@1|root,COG5000@1|root,COG5002@1|root,COG1352@2|Bacteria,COG2202@2|Bacteria,COG2205@2|Bacteria,COG5000@2|Bacteria,COG5002@2|Bacteria,2IWSR@203682|Planctomycetes 203682|Planctomycetes NT catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR - - 2.1.1.80,3.1.1.61 ko:K13924 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko02022,ko02035 - - - CheB_methylest,CheR,CheR_N,HATPase_c,HisKA,PAS,PAS_10,PAS_3,PAS_4,Response_reg k59_1509218_1 335543.Sfum_2865 9.27e-21 97.8 COG0421@1|root,COG0421@2|Bacteria,1P220@1224|Proteobacteria,42NG6@68525|delta/epsilon subdivisions,2WIRU@28221|Deltaproteobacteria,2MQH9@213462|Syntrophobacterales 28221|Deltaproteobacteria E Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine - - - - - - - - - - - - Spermine_synth k59_888007_1 944435.AXAJ01000002_gene4564 9.19e-49 167.0 COG0223@1|root,COG0223@2|Bacteria,1MU4Q@1224|Proteobacteria,2VIS2@28216|Betaproteobacteria,1K23X@119060|Burkholderiaceae 28216|Betaproteobacteria J Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus fmt - 2.1.2.9 ko:K00604 ko00670,ko00970,map00670,map00970 - R03940 RC00026,RC00165 ko00000,ko00001,ko01000 - - - Formyl_trans_C,Formyl_trans_N k59_994424_1 199310.c4186 6.8e-135 403.0 COG0370@1|root,COG0370@2|Bacteria,1MUZC@1224|Proteobacteria,1RME9@1236|Gammaproteobacteria,3XNS0@561|Escherichia 1236|Gammaproteobacteria P Transporter of a GTP-driven Fe(2 ) uptake system feoB GO:0000041,GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0005215,GO:0005381,GO:0005488,GO:0005515,GO:0005525,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006826,GO:0006950,GO:0006974,GO:0008150,GO:0008324,GO:0009987,GO:0015075,GO:0015093,GO:0015318,GO:0015684,GO:0016020,GO:0017076,GO:0019001,GO:0022857,GO:0022890,GO:0030001,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0033554,GO:0034220,GO:0034755,GO:0035639,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0044464,GO:0046873,GO:0046915,GO:0050896,GO:0051179,GO:0051234,GO:0051716,GO:0055085,GO:0070838,GO:0071944,GO:0072509,GO:0072511,GO:0097159,GO:0097367,GO:0098655,GO:0098660,GO:0098662,GO:1901265,GO:1901363,GO:1903874 - ko:K04759 - - - - ko00000,ko02000 9.A.8.1 - iECs_1301.ECs4251,iYL1228.KPN_03779 FeoB_C,FeoB_N,Gate k59_1396167_2 926566.Terro_3831 1.62e-16 79.7 COG3176@1|root,COG3176@2|Bacteria,3Y727@57723|Acidobacteria,2JKDW@204432|Acidobacteriia 204432|Acidobacteriia S Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_5 k59_1224121_1 1229909.NSED_00410 2.49e-14 69.7 arCOG08825@1|root,arCOG08825@2157|Archaea,41T4G@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_888016_1 316407.85675884 2.66e-117 343.0 COG2813@1|root,COG2813@2|Bacteria,1NEMR@1224|Proteobacteria,1RMXE@1236|Gammaproteobacteria,3XMGF@561|Escherichia 1236|Gammaproteobacteria J Specifically methylates the guanine in position 1835 (m2G1835) of 23S rRNA rlmG GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0008990,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0052916,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.172,2.1.1.174 ko:K00564,ko:K11391 - - R07234 RC00003 ko00000,ko01000,ko03009 - - - MTS k59_1224124_1 765911.Thivi_0015 2.47e-70 224.0 COG0416@1|root,COG0416@2|Bacteria,1MVM3@1224|Proteobacteria,1RM7R@1236|Gammaproteobacteria,1WW6R@135613|Chromatiales 135613|Chromatiales I Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA plsX - 2.3.1.15 ko:K03621 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R00851,R09380 RC00004,RC00039,RC00041 ko00000,ko00001,ko00002,ko01000,ko01004 - - - FA_synthesis k59_1168096_1 316407.85675543 4.09e-113 330.0 COG0650@1|root,COG0650@2|Bacteria,1MXV5@1224|Proteobacteria,1RPCY@1236|Gammaproteobacteria,3XNSF@561|Escherichia 1236|Gammaproteobacteria C oxidoreductase activity hycD GO:0005575,GO:0005623,GO:0005886,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0016020,GO:0033554,GO:0044464,GO:0050896,GO:0051716,GO:0071944 - ko:K12138,ko:K15829 - - - - ko00000,ko01000 - - iSFV_1184.SFV_2781,iUMNK88_1353.UMNK88_3079,iYL1228.KPN_03059 NADHdh k59_1057217_2 467661.RKLH11_3913 2.64e-05 43.9 COG3636@1|root,COG3636@2|Bacteria,1N0RK@1224|Proteobacteria,2UDN3@28211|Alphaproteobacteria 28211|Alphaproteobacteria K Transcriptional regulator - - - - - - - - - - - - - k59_542643_1 1122604.JONR01000007_gene2768 3.61e-62 206.0 COG0773@1|root,COG0773@2|Bacteria,1MV68@1224|Proteobacteria,1RN88@1236|Gammaproteobacteria,1X3C1@135614|Xanthomonadales 135614|Xanthomonadales M Belongs to the MurCDEF family murC - 6.3.2.8 ko:K01924 ko00471,ko00550,ko01100,map00471,map00550,map01100 - R03193 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_542643_2 222534.KB893671_gene3285 3.9e-37 141.0 COG0772@1|root,COG0772@2|Bacteria,2GKXP@201174|Actinobacteria,4ES9A@85013|Frankiales 201174|Actinobacteria D Belongs to the SEDS family ftsW GO:0008150,GO:0040007 2.4.1.227 ko:K02563,ko:K03588 ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112 - R05032,R05662 RC00005,RC00049 ko00000,ko00001,ko01000,ko01011,ko02000,ko03036 2.A.103.1 GT28 - FTSW_RODA_SPOVE k59_1448604_1 314287.GB2207_02532 4.79e-80 241.0 COG0694@1|root,COG0694@2|Bacteria,1MU8Y@1224|Proteobacteria,1RN7J@1236|Gammaproteobacteria,1J51B@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins nfuA GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006790,GO:0006807,GO:0006873,GO:0006875,GO:0006879,GO:0006950,GO:0006979,GO:0007154,GO:0008150,GO:0008152,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0010106,GO:0010467,GO:0015976,GO:0016043,GO:0016226,GO:0019538,GO:0019725,GO:0022607,GO:0030003,GO:0031163,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0042592,GO:0042594,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046916,GO:0048037,GO:0048878,GO:0050801,GO:0050896,GO:0051186,GO:0051536,GO:0051539,GO:0051540,GO:0051604,GO:0051716,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0065007,GO:0065008,GO:0071496,GO:0071704,GO:0071840,GO:0097428,GO:0098771,GO:1901564 - ko:K07400 - - - - ko00000 - - - Fe-S_biosyn,NifU k59_265888_1 1415778.JQMM01000001_gene1800 1.64e-07 51.6 COG0326@1|root,COG0326@2|Bacteria,1MUUE@1224|Proteobacteria,1RNWD@1236|Gammaproteobacteria,1J4YG@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O Molecular chaperone. Has ATPase activity htpG GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006950,GO:0006974,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0033554,GO:0042623,GO:0042802,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716 - ko:K04079 ko04141,ko04151,ko04217,ko04612,ko04621,ko04626,ko04657,ko04659,ko04914,ko04915,ko05200,ko05215,ko05418,map04141,map04151,map04217,map04612,map04621,map04626,map04657,map04659,map04914,map04915,map05200,map05215,map05418 - - - ko00000,ko00001,ko01009,ko03029,ko03051,ko03110,ko04131,ko04147 - - - HATPase_c,HATPase_c_3,HSP90 k59_431836_1 1144305.PMI02_00867 2.34e-79 239.0 2DX2E@1|root,34327@2|Bacteria,1NYZE@1224|Proteobacteria,2USZI@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_431836_2 1479239.JQMU01000001_gene419 1.58e-47 166.0 COG2271@1|root,COG2271@2|Bacteria,1QVY6@1224|Proteobacteria,2TWTV@28211|Alphaproteobacteria,2KEFC@204457|Sphingomonadales 204457|Sphingomonadales G Major facilitator superfamily - - - - - - - - - - - - MFS_1 k59_995495_1 1504981.KO116_0725 4.7e-08 51.6 2CNK3@1|root,31TH7@2|Bacteria,1R38H@1224|Proteobacteria,1S7X7@1236|Gammaproteobacteria,1XKY6@135619|Oceanospirillales 135619|Oceanospirillales S Protein of Unknown function (DUF2784) - - - - - - - - - - - - DUF2784 k59_995495_2 754476.Q7A_2750 3.65e-89 267.0 COG1432@1|root,COG1432@2|Bacteria,1MX5C@1224|Proteobacteria,1RSP8@1236|Gammaproteobacteria,461GG@72273|Thiotrichales 72273|Thiotrichales S OST-HTH/LOTUS domain - - - - - - - - - - - - NYN,OST-HTH k59_1675109_1 1122137.AQXF01000004_gene1825 8.39e-201 560.0 COG0825@1|root,COG0825@2|Bacteria,1MURN@1224|Proteobacteria,2TR6V@28211|Alphaproteobacteria 28211|Alphaproteobacteria I Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA accA - 2.1.3.15,6.4.1.2 ko:K01962 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04386 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 - - - ACCA k59_1278527_2 1216007.AOPM01000073_gene1346 1.19e-40 144.0 COG4675@1|root,COG4675@2|Bacteria,1MZY9@1224|Proteobacteria,1S64Y@1236|Gammaproteobacteria,2Q2P6@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria S Phage Tail Collar Domain - - - - - - - - - - - - Collar k59_487599_1 1122137.AQXF01000007_gene3605 1.66e-85 278.0 COG2352@1|root,COG2352@2|Bacteria 2|Bacteria C phosphoenolpyruvate carboxylase activity - - 4.1.1.31 ko:K01595 ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200 M00168,M00170,M00171,M00172,M00173,M00346,M00374 R00345 RC02741 ko00000,ko00001,ko00002,ko01000 - - - PEPcase k59_1510312_1 395493.BegalDRAFT_3125 5.7e-91 279.0 COG4177@1|root,COG4177@2|Bacteria,1MV66@1224|Proteobacteria,1RPTT@1236|Gammaproteobacteria 1236|Gammaproteobacteria E Belongs to the binding-protein-dependent transport system permease family livM GO:0003333,GO:0003674,GO:0005215,GO:0005304,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006855,GO:0006865,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0015075,GO:0015171,GO:0015173,GO:0015175,GO:0015179,GO:0015188,GO:0015192,GO:0015238,GO:0015318,GO:0015658,GO:0015711,GO:0015801,GO:0015803,GO:0015804,GO:0015807,GO:0015818,GO:0015823,GO:0015829,GO:0015849,GO:0015893,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0042221,GO:0042493,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0098655,GO:0098656,GO:1902475,GO:1903714,GO:1903785,GO:1903825,GO:1905039 - ko:K01998 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - iPC815.YPO3806,iSDY_1059.SDY_3605 BPD_transp_2,DUF3382 k59_605808_1 232721.Ajs_0374 8.99e-25 104.0 COG0809@1|root,COG0809@2|Bacteria,1MUH3@1224|Proteobacteria,2VHJF@28216|Betaproteobacteria,4ACTD@80864|Comamonadaceae 28216|Betaproteobacteria H Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) queA GO:0002097,GO:0002099,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016853,GO:0018130,GO:0019438,GO:0034404,GO:0034470,GO:0034641,GO:0034654,GO:0034660,GO:0042455,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0051075,GO:0055086,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 2.4.99.17 ko:K07568 - - - - ko00000,ko01000,ko03016 - - - Queuosine_synth k59_828796_1 1118060.CAGZ01000005_gene1631 0.000465 42.0 COG0745@1|root,COG0745@2|Bacteria,2IHFU@201174|Actinobacteria,4CUK8@84998|Coriobacteriia 84998|Coriobacteriia K Response regulator receiver domain - - - ko:K18349 ko01502,ko02020,map01502,map02020 M00652,M00657 - - ko00000,ko00001,ko00002,ko01504,ko02022 - - - Response_reg,Trans_reg_C k59_828796_2 575589.HMPREF0018_02368 4.26e-09 56.2 COG4969@1|root,COG4969@2|Bacteria,1N7EQ@1224|Proteobacteria,1SCES@1236|Gammaproteobacteria,3NPSI@468|Moraxellaceae 1236|Gammaproteobacteria NU pilus assembly protein major pilin PilA pilA - - ko:K02650,ko:K02655 ko02020,map02020 - - - ko00000,ko00001,ko02035,ko02044 3.A.15.2 - - N_methyl,Pilin k59_265921_1 320483.AMF_234 2.25e-34 128.0 COG1054@1|root,COG1054@2|Bacteria,1MUFV@1224|Proteobacteria,2TUB5@28211|Alphaproteobacteria,47F8D@766|Rickettsiales 766|Rickettsiales S Belongs to the UPF0176 family - - - ko:K07146 - - - - ko00000 - - - Rhodanese k59_889154_1 436308.Nmar_1145 2.95e-28 104.0 COG0526@1|root,arCOG01218@2157|Archaea 2157|Archaea CO TIGRFAM Glutaredoxin-like domain protein - - - - - - - - - - - - Thioredoxin_3 k59_889154_2 436308.Nmar_0199 7.18e-30 107.0 arCOG10519@1|root,arCOG10519@2157|Archaea,41T6D@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_657732_1 1443665.JACA01000020_gene4970 1.37e-23 103.0 COG1629@1|root,COG1629@2|Bacteria,COG4771@2|Bacteria,4NDU8@976|Bacteroidetes,1HXFM@117743|Flavobacteriia,2YH1X@290174|Aquimarina 976|Bacteroidetes P TonB dependent receptor - - - - - - - - - - - - CarbopepD_reg_2,Plug,TonB_dep_Rec k59_1057268_1 1278309.KB907099_gene2933 2.79e-70 226.0 COG0492@1|root,COG1145@1|root,COG0492@2|Bacteria,COG1145@2|Bacteria,1QYEW@1224|Proteobacteria,1T3PI@1236|Gammaproteobacteria 1236|Gammaproteobacteria CO Pyridine nucleotide-disulphide oxidoreductase - - - - - - - - - - - - Fer4,Fer4_5,Pyr_redox_3 k59_1620724_1 1122137.AQXF01000002_gene146 6.45e-128 377.0 COG0008@1|root,COG0008@2|Bacteria,1MUCR@1224|Proteobacteria,2TRSU@28211|Alphaproteobacteria 28211|Alphaproteobacteria J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) gltX - 6.1.1.17 ko:K01885 ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120 M00121,M00359,M00360 R05578 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016 - - - tRNA-synt_1c k59_487644_1 926550.CLDAP_06210 1.11e-119 359.0 COG1274@1|root,COG1274@2|Bacteria,2G7VM@200795|Chloroflexi 200795|Chloroflexi H Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle pckG - 4.1.1.32 ko:K01596 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko03320,ko04068,ko04151,ko04152,ko04910,ko04920,ko04922,ko04931,ko04964,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map03320,map04068,map04151,map04152,map04910,map04920,map04922,map04931,map04964 M00003 R00431,R00726 RC00002,RC02741 ko00000,ko00001,ko00002,ko01000 - - - PEPCK_C,PEPCK_N k59_1785189_1 751944.HALDL1_14330 6.58e-08 59.7 COG0421@1|root,arCOG00050@2157|Archaea,2XUEJ@28890|Euryarchaeota,23T1E@183963|Halobacteria 183963|Halobacteria E Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine speE - - - - - - - - - - - Spermine_synth k59_265939_1 395494.Galf_1333 7.86e-105 319.0 COG1053@1|root,COG1053@2|Bacteria,1MU5M@1224|Proteobacteria,2VHM6@28216|Betaproteobacteria,44V9G@713636|Nitrosomonadales 28216|Betaproteobacteria C Belongs to the FAD-dependent oxidoreductase 2 family. FRD SDH subfamily sdhA GO:0000104,GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009055,GO:0009060,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016627,GO:0016999,GO:0017144,GO:0019752,GO:0022900,GO:0032991,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0045273,GO:0045274,GO:0045281,GO:0045282,GO:0045333,GO:0048037,GO:0050660,GO:0050662,GO:0055114,GO:0070469,GO:0070470,GO:0071704,GO:0071944,GO:0072350,GO:0097159,GO:0098796,GO:0098797,GO:0098803,GO:1901265,GO:1901363,GO:1902494,GO:1990204 1.3.5.1,1.3.5.4 ko:K00239 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134 M00009,M00011,M00149,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,Succ_DH_flav_C k59_96731_1 1384056.N787_04270 2.15e-35 129.0 COG0194@1|root,COG0194@2|Bacteria,1MW92@1224|Proteobacteria,1RN09@1236|Gammaproteobacteria,1X4E7@135614|Xanthomonadales 135614|Xanthomonadales F Essential for recycling GMP and indirectly, cGMP gmk GO:0003674,GO:0003824,GO:0004385,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009126,GO:0009132,GO:0009135,GO:0009150,GO:0009161,GO:0009165,GO:0009167,GO:0009179,GO:0009185,GO:0009259,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0042278,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046037,GO:0046128,GO:0046483,GO:0046710,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901576,GO:1901657 2.7.4.8 ko:K00942 ko00230,ko01100,map00230,map01100 M00050 R00332,R02090 RC00002 ko00000,ko00001,ko00002,ko01000 - - - Guanylate_kin k59_96731_2 487316.BBNM01000002_gene1158 8.47e-25 95.1 COG1758@1|root,COG1758@2|Bacteria,1N6TX@1224|Proteobacteria,1SCSR@1236|Gammaproteobacteria,3NNVY@468|Moraxellaceae 1236|Gammaproteobacteria K Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits rpoZ GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0030880,GO:0032774,GO:0032991,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234 2.7.7.6 ko:K03060 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb6 k59_1675168_1 1458427.BAWN01000015_gene992 6.6e-64 201.0 28HYK@1|root,2Z83Z@2|Bacteria,1MY0H@1224|Proteobacteria,2W10U@28216|Betaproteobacteria 28216|Betaproteobacteria S Protein of unknown function (DUF3800) - - - - - - - - - - - - DUF3800 k59_1675168_2 1458427.BAWN01000015_gene993 4.3e-33 125.0 2DBKD@1|root,2Z9SP@2|Bacteria,1PCCH@1224|Proteobacteria,2W3DS@28216|Betaproteobacteria 28216|Betaproteobacteria S Domain of unknown function (DUF4263) - - - - - - - - - - - - DUF4263 k59_889177_1 1229909.NSED_08875 4.41e-64 216.0 COG0640@1|root,COG1328@1|root,arCOG01680@2157|Archaea,arCOG04889@2157|Archaea,41SBG@651137|Thaumarchaeota 651137|Thaumarchaeota FK Anaerobic ribonucleoside-triphosphate reductase - - 1.1.98.6 ko:K21636 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R11633,R11634,R11635,R11636 RC00613 ko00000,ko00001,ko00002,ko01000 - - - ATP-cone,HTH_20,NRDD k59_159700_1 398512.JQKC01000008_gene989 2.28e-14 79.0 COG0515@1|root,COG0515@2|Bacteria,1TP3F@1239|Firmicutes,2492G@186801|Clostridia,3WGK8@541000|Ruminococcaceae 186801|Clostridia KLT serine threonine protein kinase prkC - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - PASTA,Pkinase k59_666967_1 582899.Hden_0691 9.41e-132 381.0 COG1148@1|root,COG1148@2|Bacteria,1R882@1224|Proteobacteria,2U526@28211|Alphaproteobacteria 28211|Alphaproteobacteria C FAD dependent oxidoreductase - - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 ko:K03388 ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200 M00356,M00357,M00563,M00567 R04540,R11928,R11931,R11943,R11944 RC00011 ko00000,ko00001,ko00002,ko01000 - - - FAD_oxidored,Pyr_redox_2 k59_1233277_1 754476.Q7A_637 8.56e-100 306.0 COG0173@1|root,COG0173@2|Bacteria,1MUXB@1224|Proteobacteria,1RNMI@1236|Gammaproteobacteria,45ZZ8@72273|Thiotrichales 72273|Thiotrichales J Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) aspS - 6.1.1.12 ko:K01876 ko00970,map00970 M00359,M00360 R05577 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - GAD,tRNA-synt_2,tRNA_anti-codon k59_49385_1 981369.JQMJ01000004_gene3844 1.35e-20 96.3 COG1233@1|root,COG1233@2|Bacteria,2GJ80@201174|Actinobacteria,2NF9U@228398|Streptacidiphilus 201174|Actinobacteria Q NAD(P)-binding Rossmann-like domain - - - - - - - - - - - - Amino_oxidase,NAD_binding_8 k59_1233280_1 1202768.JROF01000035_gene2241 2.04e-09 58.2 COG3865@1|root,arCOG09469@2157|Archaea,2Y3A8@28890|Euryarchaeota 28890|Euryarchaeota S 3-demethylubiquinone-9 3-methyltransferase - - - - - - - - - - - - 3-dmu-9_3-mt k59_1344018_1 316407.4062446 8.92e-22 86.7 COG0393@1|root,COG0393@2|Bacteria,1N0XM@1224|Proteobacteria,1S62I@1236|Gammaproteobacteria,3XPSK@561|Escherichia 1236|Gammaproteobacteria S Belongs to the UPF0145 family ybjQ - - - - - - - - - - - YbjQ_1 k59_1344018_2 316407.4062447 3.66e-111 323.0 COG3023@1|root,COG3023@2|Bacteria,1RDHU@1224|Proteobacteria,1RMDN@1236|Gammaproteobacteria,3XNYK@561|Escherichia 1236|Gammaproteobacteria V N-acetyl-anhydromuramoyl-L-alanine amidase activity amiD GO:0000270,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0006022,GO:0006026,GO:0006027,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008745,GO:0009056,GO:0009057,GO:0009253,GO:0009254,GO:0009392,GO:0016020,GO:0016787,GO:0016810,GO:0016811,GO:0019867,GO:0030203,GO:0043167,GO:0043169,GO:0043170,GO:0046872,GO:0046914,GO:0061783,GO:0071704,GO:1901135,GO:1901136,GO:1901564,GO:1901565,GO:1901575 3.5.1.28 ko:K01447,ko:K11066 - - R04112 RC00064,RC00141 ko00000,ko01000,ko01011 - - - Amidase_2,PG_binding_1 k59_49399_1 96561.Dole_0013 3.34e-79 253.0 COG0064@1|root,COG0064@2|Bacteria,1MUKG@1224|Proteobacteria,42M31@68525|delta/epsilon subdivisions,2WJK4@28221|Deltaproteobacteria,2MIIZ@213118|Desulfobacterales 28221|Deltaproteobacteria J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) gatB GO:0003674,GO:0003824,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564 6.3.5.6,6.3.5.7 ko:K02434 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - GatB_N,GatB_Yqey k59_1287770_1 1121946.AUAX01000001_gene2165 4.53e-106 328.0 COG2274@1|root,COG2274@2|Bacteria,2I2QC@201174|Actinobacteria,4DMCS@85008|Micromonosporales 201174|Actinobacteria V ABC transporter transmembrane region - - - ko:K06147 - - - - ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran,Peptidase_C39 k59_1629229_1 1000565.METUNv1_03635 3.55e-45 165.0 COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,2VKJ8@28216|Betaproteobacteria,2KW95@206389|Rhodocyclales 206389|Rhodocyclales KLT Protein tyrosine kinase - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase k59_1344029_1 314287.GB2207_09656 1.04e-45 169.0 COG1629@1|root,COG1629@2|Bacteria,1MX4K@1224|Proteobacteria,1RP6B@1236|Gammaproteobacteria,1J4RA@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P COG1629 Outer membrane receptor proteins, mostly Fe transport - - - - - - - - - - - - Plug,TonB_dep_Rec k59_1793963_1 159087.Daro_3360 1.72e-47 162.0 COG0631@1|root,COG0631@2|Bacteria,1R7UF@1224|Proteobacteria,2VM6F@28216|Betaproteobacteria,2KUQG@206389|Rhodocyclales 206389|Rhodocyclales T Serine/threonine phosphatases, family 2C, catalytic domain pppL - 3.1.3.16 ko:K20074 - - - - ko00000,ko01000,ko01009 - - - PP2C_2 k59_837672_1 240292.Ava_0168 4.25e-34 133.0 COG0212@1|root,COG0212@2|Bacteria,1G2B2@1117|Cyanobacteria,1HKTF@1161|Nostocales 1117|Cyanobacteria H Belongs to the 5-formyltetrahydrofolate cyclo-ligase family - - - - - - - - - - - - - k59_1576440_1 1298593.TOL_1523 8.36e-101 304.0 COG0160@1|root,COG0160@2|Bacteria,1MWY6@1224|Proteobacteria,1RQKU@1236|Gammaproteobacteria,1XJ2M@135619|Oceanospirillales 135619|Oceanospirillales E Aminotransferase class-III - - 2.6.1.76 ko:K00836 ko00260,ko01100,ko01120,ko01210,ko01230,map00260,map01100,map01120,map01210,map01230 M00033 R06977 RC00006,RC00062 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 k59_1793975_1 713586.KB900536_gene3007 2.64e-77 233.0 COG0328@1|root,COG0328@2|Bacteria,1RCZ1@1224|Proteobacteria,1S3YC@1236|Gammaproteobacteria,1WYRV@135613|Chromatiales 135613|Chromatiales L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids rnhA - 3.1.26.4 ko:K03469 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - RNase_H k59_614783_1 1279017.AQYJ01000019_gene1449 3.49e-47 156.0 COG0088@1|root,COG0088@2|Bacteria,1MXPF@1224|Proteobacteria,1RNNK@1236|Gammaproteobacteria,464IZ@72275|Alteromonadaceae 1236|Gammaproteobacteria J Forms part of the polypeptide exit tunnel rplD GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003700,GO:0003723,GO:0003735,GO:0004857,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005844,GO:0006355,GO:0006412,GO:0006417,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0008428,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015934,GO:0016043,GO:0017148,GO:0019219,GO:0019222,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030234,GO:0030371,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032069,GO:0032074,GO:0032268,GO:0032269,GO:0032991,GO:0032993,GO:0034248,GO:0034249,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042788,GO:0043043,GO:0043086,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044092,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0045182,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0051252,GO:0051253,GO:0051336,GO:0051346,GO:0060255,GO:0060698,GO:0060699,GO:0060700,GO:0060701,GO:0060702,GO:0065003,GO:0065007,GO:0065009,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0080090,GO:0097159,GO:0098772,GO:0140110,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1902679,GO:1903506,GO:1903507,GO:1990904,GO:2000112,GO:2000113,GO:2001141 - ko:K02926 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L4 k59_614783_2 745014.OMB55_00001800 1.33e-57 183.0 COG0087@1|root,COG0087@2|Bacteria,1MUST@1224|Proteobacteria,1RMK9@1236|Gammaproteobacteria,1J55G@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit rplC GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02906 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L3 k59_105338_1 595460.RRSWK_05626 7.19e-101 312.0 COG0381@1|root,COG0381@2|Bacteria,2J0I1@203682|Planctomycetes 203682|Planctomycetes M UDP-N-acetylglucosamine 2-epimerase - - 5.1.3.14 ko:K01791 ko00520,ko01100,ko05111,map00520,map01100,map05111 M00362 R00420 RC00290 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Epimerase_2 k59_105338_2 90813.JQMT01000001_gene734 1.2e-06 52.0 COG0517@1|root,COG1208@1|root,COG0517@2|Bacteria,COG1208@2|Bacteria,1MUYJ@1224|Proteobacteria,1RQPI@1236|Gammaproteobacteria,461QS@72273|Thiotrichales 72273|Thiotrichales JM Nucleotidyl transferase - - - - - - - - - - - - CBS,NTP_transferase k59_440651_1 1123060.JONP01000017_gene5344 2.25e-10 65.1 COG2802@1|root,COG2802@2|Bacteria,1NV9N@1224|Proteobacteria,2TQZ4@28211|Alphaproteobacteria,2JS8Z@204441|Rhodospirillales 204441|Rhodospirillales S to the N-terminal domain of Lon protease lonD - 3.4.21.53 ko:K01338,ko:K07157 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - LON_substr_bdg k59_778223_1 1125863.JAFN01000001_gene3461 1.53e-90 280.0 COG0459@1|root,COG0459@2|Bacteria,1MURR@1224|Proteobacteria,42M52@68525|delta/epsilon subdivisions,2WIRK@28221|Deltaproteobacteria 28221|Deltaproteobacteria O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions groL GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0016465,GO:0032991,GO:0044183,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0051082,GO:0061077,GO:0101031,GO:1990220 - ko:K04077 ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 - - - Cpn60_TCP1 k59_778223_2 243159.AFE_0543 6.65e-06 45.1 COG0234@1|root,COG0234@2|Bacteria,1MZ2X@1224|Proteobacteria,1S8YR@1236|Gammaproteobacteria,2ND4V@225057|Acidithiobacillales 225057|Acidithiobacillales O Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter groS - - ko:K04078 - - - - ko00000,ko03029,ko03110 - - - Cpn10 k59_551699_1 316407.4062692 3.42e-126 362.0 COG0846@1|root,COG0846@2|Bacteria,1MUK1@1224|Proteobacteria,1RMX5@1236|Gammaproteobacteria,3XMVH@561|Escherichia 1236|Gammaproteobacteria K NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form cobB GO:0002252,GO:0002376,GO:0003674,GO:0003824,GO:0006464,GO:0006476,GO:0006807,GO:0006935,GO:0006950,GO:0006952,GO:0008150,GO:0008152,GO:0009605,GO:0009607,GO:0009615,GO:0009987,GO:0016787,GO:0016810,GO:0016811,GO:0018193,GO:0018205,GO:0019213,GO:0019538,GO:0033558,GO:0034979,GO:0034983,GO:0035601,GO:0036048,GO:0036049,GO:0036055,GO:0036211,GO:0040011,GO:0042221,GO:0042330,GO:0043170,GO:0043207,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0050896,GO:0051607,GO:0051704,GO:0051707,GO:0071704,GO:0098542,GO:0098732,GO:0140096,GO:1901564 - ko:K12410 - - - - ko00000,ko01000 - - - SIR2 k59_1684507_2 983920.Y88_0008 3.35e-78 235.0 2DBX8@1|root,2ZBN7@2|Bacteria,1RABM@1224|Proteobacteria,2U5PN@28211|Alphaproteobacteria 28211|Alphaproteobacteria S nitrogen fixation protein - - - - - - - - - - - - DUF269 k59_1684507_3 555793.WSK_1763 9.71e-23 89.0 COG5420@1|root,COG5420@2|Bacteria,1N74Y@1224|Proteobacteria,2UH4J@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Evidence 4 Homologs of previously reported genes of msi338 - - - - - - - - - - - Rop-like k59_216984_1 1269813.ATUL01000003_gene2449 4.02e-40 141.0 COG0501@1|root,COG0501@2|Bacteria,1MUV4@1224|Proteobacteria,1RMN0@1236|Gammaproteobacteria,1WWI6@135613|Chromatiales 135613|Chromatiales O Belongs to the peptidase M48B family htpX - - ko:K03799 - M00743 - - ko00000,ko00002,ko01000,ko01002 - - - Peptidase_M48 k59_496111_1 675812.VHA_000734 3.35e-25 111.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,1RMH0@1236|Gammaproteobacteria,1XV3Y@135623|Vibrionales 135623|Vibrionales NT chemotaxis protein - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - HAMP,MCPsignal,PAS_8,PAS_9 k59_333933_1 1545915.JROG01000004_gene2235 2.32e-47 162.0 COG2175@1|root,COG2175@2|Bacteria,1MV5K@1224|Proteobacteria,2TQTZ@28211|Alphaproteobacteria,2JZYD@204457|Sphingomonadales 204457|Sphingomonadales Q dioxygenase - - - ko:K22303 - - - - ko00000,ko01000 - - - TauD k59_1234625_1 518766.Rmar_1625 2.11e-41 151.0 COG0165@1|root,COG0165@2|Bacteria,4NFCY@976|Bacteroidetes,1FJSI@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes E Lyase argH GO:0003674,GO:0003824,GO:0004056,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016829,GO:0016840,GO:0016842,GO:0019752,GO:0042450,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.3.2.1 ko:K01755 ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230 M00029,M00844,M00845 R01086 RC00445,RC00447 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Lyase_1 k59_1685931_1 631362.Thi970DRAFT_03338 2.09e-115 354.0 COG0296@1|root,COG0296@2|Bacteria,1QTVN@1224|Proteobacteria,1RQSK@1236|Gammaproteobacteria,1WWAD@135613|Chromatiales 135613|Chromatiales G Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position glgB - 2.4.1.18 ko:K00700 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R02110 - ko00000,ko00001,ko00002,ko01000,ko04147 - CBM48,GH13 - Alpha-amylase,Alpha-amylase_C,CBM_48 k59_1685938_1 991905.SL003B_1738 2.06e-56 176.0 COG0051@1|root,COG0051@2|Bacteria,1RGWF@1224|Proteobacteria,2U95D@28211|Alphaproteobacteria,4BQFP@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria J Involved in the binding of tRNA to the ribosomes rpsJ GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02946 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S10 k59_1685938_2 1121022.ABENE_19930 4.34e-22 91.7 COG0087@1|root,COG0087@2|Bacteria,1MUST@1224|Proteobacteria,2TRHB@28211|Alphaproteobacteria,2KF4V@204458|Caulobacterales 204458|Caulobacterales J One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit rplC - - ko:K02906 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L3 k59_218335_2 1215092.PA6_038_00210 2.93e-12 66.6 COG3312@1|root,COG3312@2|Bacteria,1N777@1224|Proteobacteria,1SD0Z@1236|Gammaproteobacteria,1YG4A@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria C ATP synthase I chain atpI GO:0003674,GO:0003824,GO:0005215,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044769,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - ko:K02116 - - - - ko00000,ko00194 3.A.2.1 - - ATP-synt_I k59_218335_3 981336.F944_03080 3.72e-77 242.0 COG0356@1|root,COG0356@2|Bacteria,1MV87@1224|Proteobacteria,1RPHK@1236|Gammaproteobacteria,3NJCY@468|Moraxellaceae 1236|Gammaproteobacteria C it plays a direct role in the translocation of protons across the membrane atpB GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0005887,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016021,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0031224,GO:0031226,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0042777,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045263,GO:0045264,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - ko:K02108 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko03110 3.A.2.1 - iAPECO1_1312.APECO1_2725,iE2348C_1286.E2348C_4048,iEC042_1314.EC042_4125,iECABU_c1320.ECABU_c42230,iECED1_1282.ECED1_4428,iECIAI39_1322.ECIAI39_4342,iECNA114_1301.ECNA114_3887,iECOK1_1307.ECOK1_4187,iECP_1309.ECP_3937,iECS88_1305.ECS88_4160,iECSF_1327.ECSF_3586,iECUMN_1333.ECUMN_4268,iEcSMS35_1347.EcSMS35_4106,iLF82_1304.LF82_0192,iNRG857_1313.NRG857_18615,iUMN146_1321.UM146_18880,iUMNK88_1353.UMNK88_4550,iUTI89_1310.UTI89_C4293,ic_1306.c4666 ATP-synt_A k59_1178797_1 717785.HYPMC_2886 3.89e-07 54.7 COG1008@1|root,COG1008@2|Bacteria,1MV7V@1224|Proteobacteria,2TSNK@28211|Alphaproteobacteria,3N6M4@45401|Hyphomicrobiaceae 28211|Alphaproteobacteria C NADH-quinone oxidoreductase chain nuoM GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 1.6.5.3 ko:K00342 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q5_N,Proton_antipo_M k59_839118_1 247634.GPB2148_502 1.91e-106 337.0 COG1366@1|root,COG2208@1|root,COG4753@1|root,COG1366@2|Bacteria,COG2208@2|Bacteria,COG4753@2|Bacteria,1QU7V@1224|Proteobacteria,1T1QA@1236|Gammaproteobacteria,1J52K@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria KT Sigma factor PP2C-like phosphatases rsbP - - - - - - - - - - - Response_reg,SpoIIE k59_1178798_1 1247963.JPHU01000009_gene2412 3.2e-85 278.0 COG0653@1|root,COG0653@2|Bacteria,1MUJZ@1224|Proteobacteria,2TTBF@28211|Alphaproteobacteria 28211|Alphaproteobacteria U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane secA GO:0000166,GO:0002790,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0009306,GO:0009987,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015627,GO:0015628,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032940,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:0098776,GO:1901265,GO:1901363,GO:1904680 - ko:K03070 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4 - - SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW k59_1178798_2 1550091.JROE01000005_gene2016 1.31e-06 49.7 COG0739@1|root,COG0739@2|Bacteria,4NGHH@976|Bacteroidetes,1ISZG@117747|Sphingobacteriia 976|Bacteroidetes M Peptidase family M23 - - - - - - - - - - - - Peptidase_M23 k59_729462_1 1382356.JQMP01000004_gene69 1.75e-17 85.1 COG3935@1|root,COG3935@2|Bacteria,2G6W5@200795|Chloroflexi,27YDD@189775|Thermomicrobia 189775|Thermomicrobia L Replication initiation and membrane attachment - - - - - - - - - - - - DnaB_2 k59_1685947_1 1090320.KB900605_gene2343 6.44e-88 278.0 COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2TQR1@28211|Alphaproteobacteria,2JZVD@204457|Sphingomonadales 28211|Alphaproteobacteria C belongs to the aldehyde dehydrogenase family betB - 1.2.1.8 ko:K00130 ko00260,ko01100,map00260,map01100 M00555 R02565,R02566 RC00080 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_391241_1 1049564.TevJSym_ah00040 1.65e-30 117.0 COG2915@1|root,COG2915@2|Bacteria,1RI8B@1224|Proteobacteria,1RPCC@1236|Gammaproteobacteria,1J6HZ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S High frequency lysogenization protein HflD homolog hflD GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006950,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009898,GO:0016020,GO:0019897,GO:0019898,GO:0031234,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0071944,GO:0098552,GO:0098562 - ko:K07153 - - - - ko00000 - - - DUF489 k59_391241_2 1046724.KB889862_gene1459 4.61e-06 47.8 COG0482@1|root,COG0482@2|Bacteria,1MUT1@1224|Proteobacteria,1RMAK@1236|Gammaproteobacteria,464B7@72275|Alteromonadaceae 1236|Gammaproteobacteria J Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 mnmA GO:0001510,GO:0002097,GO:0002098,GO:0002143,GO:0003674,GO:0003824,GO:0004808,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016741,GO:0016782,GO:0016783,GO:0030488,GO:0032259,GO:0034227,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.8.1.13 ko:K00566 ko04122,map04122 - R08700 RC02313,RC02315 ko00000,ko00001,ko01000,ko03016 - - - tRNA_Me_trans k59_497479_1 1122137.AQXF01000002_gene410 1.72e-11 64.3 COG1377@1|root,COG1377@2|Bacteria,1MUWI@1224|Proteobacteria,2TS13@28211|Alphaproteobacteria 28211|Alphaproteobacteria N Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin flhB - - ko:K02401 ko02040,map02040 - - - ko00000,ko00001,ko02035,ko02044 3.A.6.2 - - Bac_export_2 k59_497479_2 1038866.KB902809_gene2489 8.44e-24 99.0 COG1684@1|root,COG1684@2|Bacteria,1NIF4@1224|Proteobacteria,2TTHN@28211|Alphaproteobacteria,3JVDK@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria N Role in flagellar biosynthesis fliR - - ko:K02421 ko02040,map02040 - - - ko00000,ko00001,ko02035,ko02044 3.A.6.2 - - Bac_export_1 k59_333975_1 1131266.ARWQ01000001_gene1176 8.18e-29 111.0 arCOG08038@1|root,arCOG08038@2157|Archaea,41SZN@651137|Thaumarchaeota 651137|Thaumarchaeota S protein secretion by the type IV secretion system - - - - - - - - - - - - - k59_497485_2 926566.Terro_0781 1.07e-15 78.2 COG0399@1|root,COG0399@2|Bacteria,3Y2G1@57723|Acidobacteria,2JI3T@204432|Acidobacteriia 204432|Acidobacteriia E Belongs to the DegT DnrJ EryC1 family - - - - - - - - - - - - DegT_DnrJ_EryC1 k59_106760_1 748658.KB907317_gene392 6.21e-20 88.6 COG0498@1|root,COG0498@2|Bacteria,1MUWQ@1224|Proteobacteria,1TJ1K@1236|Gammaproteobacteria,1WXNM@135613|Chromatiales 135613|Chromatiales E Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine - - 4.2.3.1 ko:K01733 ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230 M00018 R01466,R05086 RC00017,RC00526 ko00000,ko00001,ko00002,ko01000 - - - PALP k59_106760_3 1280668.ATVT01000011_gene3353 2.78e-16 78.2 COG2360@1|root,COG2360@2|Bacteria,1UY1P@1239|Firmicutes,248TU@186801|Clostridia,4BX0H@830|Butyrivibrio 186801|Clostridia O Leucyl/phenylalanyl-tRNA protein transferase aat - 2.3.2.6 ko:K00684 - - R03813,R11443,R11444 RC00055,RC00064 ko00000,ko01000 - - - Leu_Phe_trans k59_1119918_1 1545702.LACWKB8_0428 1.57e-19 86.3 COG0698@1|root,COG0698@2|Bacteria,1U9Y4@1239|Firmicutes,4HE4C@91061|Bacilli,3F41M@33958|Lactobacillaceae 91061|Bacilli G Ribose/Galactose Isomerase - - 5.3.1.26 ko:K01819 ko00052,ko01100,map00052,map01100 - R03240 RC00376 ko00000,ko00001,ko01000 - - - LacAB_rpiB k59_1119918_2 1345697.M493_04125 2.83e-26 106.0 COG0304@1|root,COG0304@2|Bacteria,1TPA7@1239|Firmicutes,4H9SD@91061|Bacilli,1WE7S@129337|Geobacillus 91061|Bacilli I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP fabF - 2.3.1.179 ko:K09458,ko:K14660 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119 RC00039,RC02728,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - iSB619.SA_RS04785 Ketoacyl-synt_C,ketoacyl-synt k59_1408129_2 436308.Nmar_1533 3.01e-148 423.0 COG0533@1|root,arCOG01183@2157|Archaea,41SDX@651137|Thaumarchaeota 651137|Thaumarchaeota L Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37 kae1 - 2.3.1.234 ko:K01409 - - R10648 RC00070,RC00416 ko00000,ko01000,ko03016 - - - Peptidase_M22 k59_1685975_1 358220.C380_01195 8.56e-64 221.0 COG1529@1|root,COG2010@1|root,COG1529@2|Bacteria,COG2010@2|Bacteria,1MV6D@1224|Proteobacteria,2WHBT@28216|Betaproteobacteria,4AATP@80864|Comamonadaceae 28216|Betaproteobacteria C Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain - - 1.17.2.1 ko:K18030 ko00760,ko01120,map00760,map01120 M00622 R09473 RC00589 ko00000,ko00001,ko00002,ko01000 - - - Ald_Xan_dh_C2,Cytochrom_C,Cytochrome_CBB3 k59_276423_2 1174504.AJTN02000206_gene3441 4.79e-06 47.0 COG0401@1|root,COG0401@2|Bacteria,1VHHJ@1239|Firmicutes,4HPX1@91061|Bacilli,1ZJHE@1386|Bacillus 91061|Bacilli S Proteolipid membrane potential modulator - - - - - - - - - - - - Pmp3 k59_276423_3 472175.EL18_01082 2.78e-15 70.9 2E4B6@1|root,32Z6W@2|Bacteria,1N7QS@1224|Proteobacteria,2UFNH@28211|Alphaproteobacteria,43KRF@69277|Phyllobacteriaceae 28211|Alphaproteobacteria S Protein of unknown function (DUF3126) MA20_32250 - - - - - - - - - - - DUF3126 k59_276423_4 1122137.AQXF01000001_gene3056 9.53e-49 159.0 2EE1V@1|root,337WM@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - Hpt k59_276423_5 1122137.AQXF01000001_gene3055 7.97e-59 187.0 COG5321@1|root,COG5321@2|Bacteria,1RDXW@1224|Proteobacteria,2U73Y@28211|Alphaproteobacteria 28211|Alphaproteobacteria S DNA repair protein MmcB-like MA20_23405 - - - - - - - - - - - MmcB-like k59_276423_6 1122137.AQXF01000001_gene3054 2.94e-59 200.0 COG3437@1|root,COG3437@2|Bacteria,1R0ZH@1224|Proteobacteria 1224|Proteobacteria KT HD domain - - - - - - - - - - - - HD_5,PAS_4 k59_1067154_1 1282876.BAOK01000001_gene2959 1.4e-129 379.0 COG1960@1|root,COG1960@2|Bacteria,1MU2V@1224|Proteobacteria,2TSK3@28211|Alphaproteobacteria,4BPRD@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria I Acyl-CoA dehydrogenase, C-terminal domain MA20_31035 - 1.3.8.7 ko:K00249 ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320 M00013,M00036,M00087 R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754 RC00052,RC00068,RC00076,RC00095,RC00148,RC00246 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_1289329_1 1396141.BATP01000023_gene569 4.47e-45 153.0 COG2095@1|root,COG2095@2|Bacteria,46T9S@74201|Verrucomicrobia,2IUN7@203494|Verrucomicrobiae 203494|Verrucomicrobiae U MarC family integral membrane protein - - - ko:K05595 - - - - ko00000,ko02000 2.A.95.1 - - MarC k59_899443_1 395493.BegalDRAFT_2410 6.81e-147 435.0 COG0376@1|root,COG0376@2|Bacteria,1MUBF@1224|Proteobacteria,1RNA5@1236|Gammaproteobacteria,4605A@72273|Thiotrichales 72273|Thiotrichales P Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity katG - 1.11.1.21 ko:K03782 ko00360,ko00380,ko00940,ko00983,ko01100,ko01110,map00360,map00380,map00940,map00983,map01100,map01110 - R00602,R00698,R02596,R02670,R03919,R04007,R07443,R11906 RC00034,RC00213,RC00767,RC02141 ko00000,ko00001,ko01000 - - - peroxidase k59_497498_1 1408473.JHXO01000001_gene2523 1.74e-12 67.8 COG1752@1|root,COG1752@2|Bacteria,4NERH@976|Bacteroidetes,2FNX7@200643|Bacteroidia 976|Bacteroidetes S Phospholipase - - - ko:K07001 - - - - ko00000 - - - Patatin k59_899445_1 929556.Solca_3368 5.25e-07 51.6 COG0243@1|root,COG0437@1|root,COG0243@2|Bacteria,COG0437@2|Bacteria,4NE5M@976|Bacteroidetes,1IPWZ@117747|Sphingobacteriia 976|Bacteroidetes C Oxidoreductase nrfC - - ko:K00184 - - - - ko00000 5.A.3 - - Fer4_7,Molydop_binding k59_899445_2 655815.ZPR_0577 1.85e-25 107.0 COG2010@1|root,COG2010@2|Bacteria,4NF0A@976|Bacteroidetes,1HXD9@117743|Flavobacteriia 976|Bacteroidetes C Cytochrome c actA - - - - - - - - - - - Cytochrom_C,Cytochrom_CIII,Cytochrome_C7 k59_779572_1 565045.NOR51B_448 7.02e-88 275.0 COG1524@1|root,COG1524@2|Bacteria,1R5V5@1224|Proteobacteria,1S06C@1236|Gammaproteobacteria,1J9AQ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S proteins of the AP superfamily pafA - - - - - - - - - - - Phosphodiest k59_1119953_1 977880.RALTA_B1366 8.27e-63 213.0 COG0296@1|root,COG0296@2|Bacteria,1QTVN@1224|Proteobacteria,2VGZZ@28216|Betaproteobacteria,1K0ZA@119060|Burkholderiaceae 28216|Betaproteobacteria G Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position glgB - 2.4.1.18 ko:K00700 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R02110 - ko00000,ko00001,ko00002,ko01000,ko04147 - CBM48,GH13 - Alpha-amylase,Alpha-amylase_C,CBM_48,Glyco_hydro_77 k59_1119953_2 1430440.MGMSRv2_0521 1.28e-72 239.0 COG1523@1|root,COG1523@2|Bacteria,1MU19@1224|Proteobacteria,2TRVS@28211|Alphaproteobacteria,2JQKB@204441|Rhodospirillales 204441|Rhodospirillales G Belongs to the glycosyl hydrolase 13 family glgX - 3.2.1.68 ko:K01214 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R09995,R11261 - ko00000,ko00001,ko00002,ko01000 - CBM48,GH13 - Alpha-amylase,CBM_48 k59_729512_1 1205680.CAKO01000040_gene991 4.26e-105 321.0 COG1123@1|root,COG4172@2|Bacteria,1MU09@1224|Proteobacteria,2TQP0@28211|Alphaproteobacteria,2JPA1@204441|Rhodospirillales 204441|Rhodospirillales P COG1123 ATPase components of various ABC-type transport systems, contain duplicated ATPase - - - ko:K02031,ko:K02032 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - ABC_tran,oligo_HPY k59_442124_1 3694.POPTR_0017s03050.1 1.96e-15 80.5 COG0265@1|root,KOG1421@2759|Eukaryota,37M01@33090|Viridiplantae,3G8IE@35493|Streptophyta,4JN34@91835|fabids 35493|Streptophyta O protease Do-like - GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009314,GO:0009416,GO:0009507,GO:0009536,GO:0009628,GO:0009642,GO:0009644,GO:0009892,GO:0010109,GO:0010205,GO:0016787,GO:0019222,GO:0019538,GO:0031323,GO:0031324,GO:0042548,GO:0043155,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043467,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0065007,GO:0071704,GO:0140096,GO:1901564,GO:1905156 - - - - - - - - - - PDZ_1,PDZ_2,Trypsin_2 k59_334018_1 87626.PTD2_15222 1.1e-40 149.0 COG0189@1|root,COG0189@2|Bacteria,1MX5X@1224|Proteobacteria,1RNXP@1236|Gammaproteobacteria,2Q1MC@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria HJ Belongs to the D-alanine--D-alanine ligase family - - - - - - - - - - - - Dala_Dala_lig_C,RLAN,RimK k59_334018_2 991905.SL003B_2271 3.88e-10 60.8 COG2133@1|root,COG2133@2|Bacteria,1MV2E@1224|Proteobacteria,2TR47@28211|Alphaproteobacteria,4BPMV@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria G Glucose / Sorbosone dehydrogenase yliI GO:0003674,GO:0003824,GO:0005488,GO:0005509,GO:0005575,GO:0005623,GO:0008150,GO:0008152,GO:0016491,GO:0016614,GO:0016901,GO:0019842,GO:0030288,GO:0030313,GO:0031406,GO:0031975,GO:0036094,GO:0042597,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0044464,GO:0046872,GO:0048037,GO:0048038,GO:0055114,GO:0070968,GO:0097159,GO:1901363 1.1.5.2 ko:K00117,ko:K21430 ko00030,ko01100,ko01110,ko01130,map00030,map01100,map01110,map01130 - R06620 RC00066 ko00000,ko00001,ko01000 - - - GSDH k59_106796_1 1137799.GZ78_25255 2.37e-77 241.0 COG0079@1|root,COG0079@2|Bacteria,1MW7I@1224|Proteobacteria,1RP4T@1236|Gammaproteobacteria,1XIP7@135619|Oceanospirillales 135619|Oceanospirillales E Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily - - - - - - - - - - - - Aminotran_1_2 k59_1067166_1 1207076.ALAT01000044_gene3437 4.7e-69 223.0 COG0405@1|root,COG0405@2|Bacteria,1MUV6@1224|Proteobacteria,1RMIT@1236|Gammaproteobacteria,1Z0SR@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria M Gamma-glutamyltransferase ggt1 - 2.3.2.2,3.4.19.13 ko:K00681 ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100 - R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935 RC00064,RC00090,RC00096 ko00000,ko00001,ko01000,ko01002 - - - G_glu_transpept k59_284636_1 1386089.N865_13390 3.6e-32 127.0 COG1020@1|root,COG1020@2|Bacteria,2HEFF@201174|Actinobacteria,4FEF5@85021|Intrasporangiaceae 201174|Actinobacteria Q Belongs to the long-chain O-acyltransferase family tgs3 GO:0000302,GO:0001666,GO:0003674,GO:0003824,GO:0004144,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006629,GO:0006638,GO:0006639,GO:0006641,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008374,GO:0008610,GO:0009058,GO:0009628,GO:0009987,GO:0010035,GO:0016020,GO:0016411,GO:0016740,GO:0016746,GO:0016747,GO:0019432,GO:0030312,GO:0036293,GO:0040007,GO:0042221,GO:0042493,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044403,GO:0044419,GO:0044464,GO:0045017,GO:0046460,GO:0046463,GO:0046486,GO:0047196,GO:0050896,GO:0051704,GO:0070482,GO:0071704,GO:0071731,GO:0071944,GO:0097366,GO:1901576,GO:1901698,GO:1901700 2.3.1.20 ko:K00635 ko00561,ko01100,map00561,map01100 M00089 R02251 RC00004,RC00041 ko00000,ko00001,ko00002,ko01000 - - - DUF1298,WES_acyltransf k59_792994_2 1279038.KB907339_gene1309 2.11e-11 60.8 COG2009@1|root,COG2009@2|Bacteria,1N02N@1224|Proteobacteria,2UC47@28211|Alphaproteobacteria,2JTDG@204441|Rhodospirillales 204441|Rhodospirillales C COG2009 Succinate dehydrogenase fumarate reductase, cytochrome b subunit sdhC - - ko:K00241 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00149,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002 - - - Sdh_cyt k59_58617_1 323850.Shew_2868 2.33e-80 258.0 COG1960@1|root,COG1960@2|Bacteria,1MU20@1224|Proteobacteria,1RPHJ@1236|Gammaproteobacteria,2QDQD@267890|Shewanellaceae 1236|Gammaproteobacteria C PFAM acyl-CoA dehydrogenase domain protein bcd - 1.3.8.1 ko:K00248 ko00071,ko00280,ko00650,ko01100,ko01110,ko01120,ko01200,ko01212,map00071,map00280,map00650,map01100,map01110,map01120,map01200,map01212 - R01175,R01178,R02661,R03172,R04751 RC00052,RC00068,RC00076,RC00120,RC00148 ko00000,ko00001,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_C,Acyl-CoA_dh_M,Acyl-CoA_dh_N,AcylCoA_DH_N k59_284641_1 1207055.C100_16845 2.58e-223 641.0 COG4774@1|root,COG4774@2|Bacteria,1R5EH@1224|Proteobacteria,2U458@28211|Alphaproteobacteria,2K054@204457|Sphingomonadales 204457|Sphingomonadales P TonB dependent receptor - - - - - - - - - - - - Plug,TonB_dep_Rec k59_1357860_1 159087.Daro_0118 1.78e-24 102.0 COG0154@1|root,COG0154@2|Bacteria,1MUVQ@1224|Proteobacteria,2VIG3@28216|Betaproteobacteria,2KUD1@206389|Rhodocyclales 206389|Rhodocyclales J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) gatA - 6.3.5.6,6.3.5.7 ko:K02433 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - Amidase k59_1357860_2 292415.Tbd_0259 1.65e-22 89.4 COG0721@1|root,COG0721@2|Bacteria,1MZQP@1224|Proteobacteria,2VUFB@28216|Betaproteobacteria 28216|Betaproteobacteria J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) gatC - 6.3.5.6,6.3.5.7 ko:K02435 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - Glu-tRNAGln k59_454745_1 1121106.JQKB01000004_gene2325 3.74e-79 250.0 COG0154@1|root,COG0154@2|Bacteria,1MUKC@1224|Proteobacteria,2TTUD@28211|Alphaproteobacteria 28211|Alphaproteobacteria J Belongs to the amidase family - - 3.5.1.4 ko:K01426 ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120 - R02540,R03096,R03180,R03909,R05551,R05590 RC00010,RC00100,RC00950,RC01025 ko00000,ko00001,ko01000 - - - Amidase k59_1415030_2 585506.HMPREF0877_0817 4.58e-29 115.0 COG0861@1|root,COG0861@2|Bacteria,1V1M1@1239|Firmicutes,4IRRE@91061|Bacilli 91061|Bacilli P Integral membrane protein TerC family - - - ko:K05794 - - - - ko00000 - - - TerC k59_1358769_2 880073.Calab_3664 9.17e-31 122.0 COG0764@1|root,COG0774@1|root,COG0764@2|Bacteria,COG0774@2|Bacteria,2NNYX@2323|unclassified Bacteria 2|Bacteria M Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis fabZ GO:0003674,GO:0003824,GO:0016829,GO:0016835,GO:0016836,GO:0019171 3.5.1.108,4.2.1.59 ko:K02372,ko:K02535,ko:K13599,ko:K16363 ko00061,ko00540,ko00780,ko01100,ko01212,ko02020,map00061,map00540,map00780,map01100,map01212,map02020 M00060,M00083,M00498,M00572 R04428,R04535,R04537,R04544,R04568,R04587,R04954,R04965,R07764,R10117,R10121 RC00166,RC00300,RC00831,RC01095 ko00000,ko00001,ko00002,ko01000,ko01004,ko01005,ko02022 - - - FabA,LpxC k59_1358769_3 1120999.JONM01000005_gene3861 1.18e-07 55.8 COG2825@1|root,COG2825@2|Bacteria,1RD8X@1224|Proteobacteria,2VRZI@28216|Betaproteobacteria,2KRDM@206351|Neisseriales 206351|Neisseriales M Belongs to the skp family ompH - - ko:K06142 - - - - ko00000 - - - OmpH k59_172548_2 948565.AFFP02000003_gene1986 6.95e-06 53.9 COG0790@1|root,COG0790@2|Bacteria,1MWPA@1224|Proteobacteria,1RPI3@1236|Gammaproteobacteria,1Y8ZS@135625|Pasteurellales 135625|Pasteurellales S Sel1-like repeats. - - - ko:K07126 - - - - ko00000 - - - Sel1 k59_1245824_1 324057.Pjdr2_0278 4.49e-50 179.0 COG0154@1|root,COG0154@2|Bacteria,1TRFI@1239|Firmicutes,4HBZA@91061|Bacilli,26RC1@186822|Paenibacillaceae 91061|Bacilli J Catalyzes the hydrolysis of a monocarboxylic acid amid to form a monocarboxylate and ammonia - - - - - - - - - - - - Amidase,SLH k59_398297_1 1122137.AQXF01000004_gene1551 5.83e-237 659.0 COG1282@1|root,COG1282@2|Bacteria,1MUP4@1224|Proteobacteria,2TQN1@28211|Alphaproteobacteria 28211|Alphaproteobacteria C The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane pntB GO:0008150,GO:0008152,GO:0055114 1.6.1.2 ko:K00325 ko00760,ko01100,map00760,map01100 - R00112 RC00001 ko00000,ko00001,ko01000 - - - PNTB k59_850281_1 1163409.UUA_16563 8.77e-41 154.0 COG1257@1|root,COG1577@1|root,COG1257@2|Bacteria,COG1577@2|Bacteria,1MXVE@1224|Proteobacteria,1RS9R@1236|Gammaproteobacteria,1X8RF@135614|Xanthomonadales 135614|Xanthomonadales I Hydroxymethylglutaryl-coenzyme A reductase - - 1.1.1.88 ko:K00054 ko00900,ko01110,ko01130,map00900,map01110,map01130 - R02081 RC00004,RC00644 ko00000,ko00001,ko01000 - - - GHMP_kinases_C,GHMP_kinases_N,HMG-CoA_red k59_172552_1 1501230.ET33_13345 3.69e-20 86.7 COG1733@1|root,COG1733@2|Bacteria,1VDT5@1239|Firmicutes,4HN6F@91061|Bacilli,26Z5B@186822|Paenibacillaceae 91061|Bacilli K Transcriptional regulator - - - - - - - - - - - - HxlR k59_172552_2 1121937.AUHJ01000017_gene2988 2.25e-05 47.0 COG0370@1|root,COG0370@2|Bacteria,1MUZC@1224|Proteobacteria,1RME9@1236|Gammaproteobacteria,464QI@72275|Alteromonadaceae 1236|Gammaproteobacteria P Ferrous iron transport protein B feoB - - ko:K04759 - - - - ko00000,ko02000 9.A.8.1 - - FeoB_C,FeoB_N,Gate k59_1189128_1 1122137.AQXF01000001_gene3009 3.38e-32 121.0 299QD@1|root,2ZWSP@2|Bacteria,1PA45@1224|Proteobacteria,2UXTH@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_1020027_1 1121935.AQXX01000104_gene370 2.46e-98 295.0 COG0192@1|root,COG0192@2|Bacteria,1MUFQ@1224|Proteobacteria,1RNV6@1236|Gammaproteobacteria,1XHEZ@135619|Oceanospirillales 135619|Oceanospirillales H Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme metK - 2.5.1.6 ko:K00789 ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230 M00034,M00035,M00368,M00609 R00177,R04771 RC00021,RC01211 ko00000,ko00001,ko00002,ko01000 - - - S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N k59_1358786_2 1117647.M5M_02765 7.03e-33 126.0 COG0072@1|root,COG0073@1|root,COG0072@2|Bacteria,COG0073@2|Bacteria,1MWKS@1224|Proteobacteria,1RMIH@1236|Gammaproteobacteria,1J4MP@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily pheT GO:0003674,GO:0003824,GO:0004812,GO:0004826,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0042802,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494 6.1.1.20 ko:K01890 ko00970,map00970 M00359,M00360 R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iG2583_1286.G2583_2160,iPC815.YPO2428 B3_4,B5,FDX-ACB,tRNA_bind k59_285512_1 1411685.U062_01873 5.52e-80 248.0 COG4658@1|root,COG4658@2|Bacteria,1MVY6@1224|Proteobacteria,1RMEU@1236|Gammaproteobacteria,1J55P@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria U Part of a membrane complex involved in electron transport rnfD GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016651,GO:0044464,GO:0055114,GO:0071944 - ko:K03614 - - - - ko00000 - - - NQR2_RnfD_RnfE k59_850292_1 1415778.JQMM01000001_gene825 4.46e-119 353.0 COG2239@1|root,COG2239@2|Bacteria,1MW24@1224|Proteobacteria,1RNE4@1236|Gammaproteobacteria,1J4XQ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P Acts as a magnesium transporter mgtE - - ko:K06213 - - - - ko00000,ko02000 1.A.26.1 - - CBS,MgtE,MgtE_N k59_850292_2 1121374.KB891579_gene1752 9.08e-15 75.5 COG3028@1|root,COG3028@2|Bacteria,1MZ4R@1224|Proteobacteria,1S9JJ@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Belongs to the UPF0307 family yjgA GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - ko:K09889 - - - - ko00000,ko03009 - - - DUF615 k59_793954_1 1122137.AQXF01000001_gene2990 3.85e-62 193.0 COG1983@1|root,COG1983@2|Bacteria,1N0KE@1224|Proteobacteria,2UCKP@28211|Alphaproteobacteria 28211|Alphaproteobacteria KT phage shock protein C pspC - - ko:K03973 - - - - ko00000,ko02048,ko03000 - - - PspC k59_1075924_1 196367.JNFG01000200_gene3122 3.18e-25 109.0 COG1530@1|root,COG1530@2|Bacteria,1MV65@1224|Proteobacteria,2VIE5@28216|Betaproteobacteria,1K2WP@119060|Burkholderiaceae 28216|Betaproteobacteria J Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs rne - 3.1.26.12 ko:K08300 ko03018,map03018 M00394 - - ko00000,ko00001,ko00002,ko01000,ko03009,ko03019 - - - RNase_E_G,S1 k59_1020033_1 68170.KL590546_gene2945 7.87e-27 114.0 COG3209@1|root,COG3209@2|Bacteria,2GP7Z@201174|Actinobacteria,4DXWA@85010|Pseudonocardiales 201174|Actinobacteria M COG3209 Rhs family protein - - - - - - - - - - - - PA14,RHS_repeat k59_906454_1 641526.ADIWIN_0214 5.26e-95 288.0 COG5368@1|root,COG5368@2|Bacteria,4NE34@976|Bacteroidetes,1HY89@117743|Flavobacteriia 976|Bacteroidetes S protein conserved in bacteria - - - - - - - - - - - - DUF3131,Glycoamylase k59_1697641_1 1122604.JONR01000053_gene4476 1.38e-84 265.0 COG3975@1|root,COG3975@2|Bacteria,1N69B@1224|Proteobacteria,1RY45@1236|Gammaproteobacteria,1X82A@135614|Xanthomonadales 135614|Xanthomonadales - - - - - - - - - - - - - - - k59_1754066_2 762966.HMPREF9439_01564 5.59e-58 186.0 COG0394@1|root,COG0394@2|Bacteria,1N0DZ@1224|Proteobacteria,2VT1B@28216|Betaproteobacteria,4PR2S@995019|Sutterellaceae 28216|Betaproteobacteria T Low molecular weight phosphatase family epsP - 3.1.3.48 ko:K01104 - - - - ko00000,ko01000 - - - LMWPc k59_1189149_1 443152.MDG893_18317 1.74e-134 402.0 COG0449@1|root,COG0449@2|Bacteria,1MW4K@1224|Proteobacteria,1RMVN@1236|Gammaproteobacteria,464V8@72275|Alteromonadaceae 1236|Gammaproteobacteria M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source glmS GO:0003674,GO:0003824,GO:0004360,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006002,GO:0006040,GO:0006047,GO:0006048,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009226,GO:0009987,GO:0016740,GO:0016769,GO:0018130,GO:0019438,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0034654,GO:0036211,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046349,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.6.1.16 ko:K00820 ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931 - R00768 RC00010,RC00163,RC02752 ko00000,ko00001,ko01000,ko01002 - - iE2348C_1286.E2348C_4039,iEC042_1314.EC042_4115,iECIAI39_1322.ECIAI39_4333,iECNA114_1301.ECNA114_3878,iECOK1_1307.ECOK1_4178,iECSF_1327.ECSF_3577,iECUMN_1333.ECUMN_4259,iEcSMS35_1347.EcSMS35_4097,iLF82_1304.LF82_0844,iNRG857_1313.NRG857_18570,iSFV_1184.SFV_3755,iSF_1195.SF3809,iSFxv_1172.SFxv_4151,iS_1188.S3959,iUMN146_1321.UM146_18835,iUTI89_1310.UTI89_C4281 GATase_6,SIS k59_1754078_2 1131266.ARWQ01000001_gene1280 6.56e-52 169.0 COG1881@1|root,arCOG04702@2157|Archaea,41T4M@651137|Thaumarchaeota 651137|Thaumarchaeota S Phosphatidylethanolamine-binding protein - - - ko:K06910 - - - - ko00000 - - - PBP k59_1302380_1 1307759.JOMJ01000003_gene2352 1.43e-55 195.0 COG0845@1|root,COG0845@2|Bacteria,1MVAS@1224|Proteobacteria,42PKU@68525|delta/epsilon subdivisions,2WM5K@28221|Deltaproteobacteria,2M9X5@213115|Desulfovibrionales 28221|Deltaproteobacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - ko:K07798,ko:K15727 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.6.1.4,8.A.1,8.A.1.2.1 - - DUF3347,HlyD_D23 k59_1189150_1 1122137.AQXF01000006_gene877 3e-09 58.9 COG2939@1|root,COG2939@2|Bacteria,1MW05@1224|Proteobacteria,2TS7R@28211|Alphaproteobacteria 28211|Alphaproteobacteria E PFAM peptidase S10 serine carboxypeptidase - - - - - - - - - - - - Peptidase_S10 k59_1189150_2 1122137.AQXF01000003_gene1990 3.03e-162 460.0 COG0583@1|root,COG0583@2|Bacteria,1MWVB@1224|Proteobacteria,2TQXV@28211|Alphaproteobacteria 28211|Alphaproteobacteria K transcriptional regulator - - - - - - - - - - - - HTH_1,LysR_substrate k59_511182_1 314285.KT71_08450 3.47e-228 660.0 COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,1RMYC@1236|Gammaproteobacteria,1J4E5@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P Cation transporter/ATPase, N-terminus - - - - - - - - - - - - Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3 k59_1358816_1 436308.Nmar_0229 1.1e-108 329.0 COG0532@1|root,arCOG01560@2157|Archaea,41SBY@651137|Thaumarchaeota 651137|Thaumarchaeota J Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2 infB - - ko:K03243 ko03013,map03013 - - - ko00000,ko00001,ko03012 - - - GTP_EFTU,GTP_EFTU_D4,IF-2 k59_624218_1 413404.Rmag_0458 4.11e-64 218.0 COG2609@1|root,COG2609@2|Bacteria,1MV21@1224|Proteobacteria,1RN6K@1236|Gammaproteobacteria,1J56P@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) aceE - 1.2.4.1 ko:K00163 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200 M00307 R00014,R00209,R01699,R03270 RC00004,RC00027,RC00627,RC02742,RC02744,RC02882 br01601,ko00000,ko00001,ko00002,ko01000 - - - Transketolase_N k59_1302386_1 926564.KI911711_gene2707 2.82e-13 73.6 COG1404@1|root,COG1404@2|Bacteria,2GJYH@201174|Actinobacteria 201174|Actinobacteria O Belongs to the peptidase S8 family - - - - - - - - - - - - Peptidase_S8,TIG k59_680675_1 314287.GB2207_09436 9.92e-79 250.0 COG0696@1|root,COG0696@2|Bacteria,1MUQ1@1224|Proteobacteria,1RMJE@1236|Gammaproteobacteria,1J4GC@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria G Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate gpmI GO:0003674,GO:0003824,GO:0004619,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016866,GO:0016868,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0030145,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046537,GO:0046700,GO:0046872,GO:0046914,GO:0046939,GO:0050896,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576 5.4.2.12 ko:K15633 ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003 R01518 RC00536 ko00000,ko00001,ko00002,ko01000 - - iECSE_1348.ECSE_3895,iJN746.PP_5056 Metalloenzyme,Phosphodiest,iPGM_N k59_1528219_1 665942.HMPREF1022_02102 3.49e-29 123.0 COG3829@1|root,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria,42N7Y@68525|delta/epsilon subdivisions,2WIX7@28221|Deltaproteobacteria,2M7ZC@213115|Desulfovibrionales 28221|Deltaproteobacteria KT sigma54 specific transcriptional regulator - - - - - - - - - - - - HTH_8,PAS,PAS_9,Sigma54_activat k59_1020067_1 1122137.AQXF01000001_gene3239 1.09e-83 253.0 COG0412@1|root,COG0412@2|Bacteria,1MW88@1224|Proteobacteria,2U1D8@28211|Alphaproteobacteria 28211|Alphaproteobacteria Q dienelactone hydrolase - - 3.1.1.45 ko:K01061 ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130 - R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222 RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686 ko00000,ko00001,ko01000 - - - DLH k59_1020067_2 1122137.AQXF01000001_gene3240 7.36e-98 293.0 COG0604@1|root,COG0604@2|Bacteria,1MWBD@1224|Proteobacteria,2TS3Z@28211|Alphaproteobacteria 28211|Alphaproteobacteria C COG0604 NADPH quinone reductase and related Zn-dependent oxidoreductases qor - 1.6.5.5 ko:K00344 - - - - ko00000,ko01000 - - - ADH_N,ADH_zinc_N k59_680691_1 1096930.L284_18620 2.42e-97 304.0 COG1506@1|root,COG1506@2|Bacteria,1P6E1@1224|Proteobacteria,2TRVE@28211|Alphaproteobacteria,2K0U1@204457|Sphingomonadales 204457|Sphingomonadales E peptidase S9 - - 3.4.14.5 ko:K01278 ko04974,map04974 - - - ko00000,ko00001,ko01000,ko01002,ko04090,ko04147 - - - DPPIV_N,Peptidase_S9 k59_1245889_1 1122137.AQXF01000005_gene1047 5.28e-115 346.0 COG0366@1|root,COG0366@2|Bacteria,1MVKX@1224|Proteobacteria,2TRS3@28211|Alphaproteobacteria 28211|Alphaproteobacteria G 'PFAM Alpha amylase, catalytic aglA GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 3.2.1.20 ko:K01187 ko00052,ko00500,ko01100,map00052,map00500,map01100 - R00028,R00801,R00802,R06087,R06088 RC00028,RC00049,RC00077 ko00000,ko00001,ko01000 - GH31 - Alpha-amylase,DUF3459,Malt_amylase_C k59_1245889_2 1122137.AQXF01000005_gene1048 2.77e-15 74.3 COG1609@1|root,COG1609@2|Bacteria,1MW7E@1224|Proteobacteria,2U1NM@28211|Alphaproteobacteria 28211|Alphaproteobacteria K transcriptional regulator - - - - - - - - - - - - LacI,Peripla_BP_3 k59_454807_1 983920.Y88_2147 2.58e-124 389.0 COG0085@1|root,COG0085@2|Bacteria,1MUC4@1224|Proteobacteria,2TS7S@28211|Alphaproteobacteria,2JZWE@204457|Sphingomonadales 204457|Sphingomonadales K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoB - 2.7.7.6 ko:K03043 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7 k59_1415097_1 439375.Oant_2853 2.48e-26 107.0 COG0161@1|root,COG0161@2|Bacteria,1MU2N@1224|Proteobacteria,2TQND@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family - - - - - - - - - - - - Aminotran_3 k59_1415097_2 861208.AGROH133_14251 2.9e-13 72.0 COG0123@1|root,COG0123@2|Bacteria,1MU7P@1224|Proteobacteria,2TRRH@28211|Alphaproteobacteria,4BJ9J@82115|Rhizobiaceae 28211|Alphaproteobacteria BQ Histone deacetylase domain - - - - - - - - - - - - Hist_deacetyl k59_1584567_1 1232683.ADIMK_3592 5.75e-202 568.0 COG2124@1|root,COG2124@2|Bacteria,1MY5H@1224|Proteobacteria,1RXYY@1236|Gammaproteobacteria,46CG0@72275|Alteromonadaceae 1236|Gammaproteobacteria Q Cytochrome P450 - - - - - - - - - - - - p450 k59_1245902_2 1122137.AQXF01000009_gene16 4.81e-96 281.0 COG0049@1|root,COG0049@2|Bacteria,1MXC8@1224|Proteobacteria,2TSI8@28211|Alphaproteobacteria 28211|Alphaproteobacteria J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA rpsG GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02992 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S7 k59_1302417_1 436308.Nmar_0482 6.77e-53 174.0 COG0581@1|root,arCOG00168@2157|Archaea,41SZ4@651137|Thaumarchaeota 651137|Thaumarchaeota P TIGRFAM phosphate ABC transporter - - - ko:K02038 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - BPD_transp_1 k59_59639_1 1415778.JQMM01000001_gene267 7.04e-26 101.0 COG1853@1|root,COG1853@2|Bacteria,1RGYM@1224|Proteobacteria,1S97V@1236|Gammaproteobacteria,1JBTB@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Flavin reductase like domain - - - - - - - - - - - - Flavin_Reduct k59_1584577_1 300852.55771856 1.41e-17 82.4 COG0517@1|root,COG0517@2|Bacteria,1WJ0F@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus S CBS domain - - - ko:K04767 - - - - ko00000 - - - ACT,CBS k59_1415107_1 443598.AUFA01000094_gene6160 6.47e-66 212.0 COG3335@1|root,COG3335@2|Bacteria,1MW7X@1224|Proteobacteria,2TTH8@28211|Alphaproteobacteria,3JWD8@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria L DDE superfamily endonuclease - - - - - - - - - - - - DDE_3,HTH_32 k59_172615_1 391603.FBALC1_12872 5.11e-45 161.0 COG0013@1|root,COG0013@2|Bacteria,4NFHW@976|Bacteroidetes,1HXDT@117743|Flavobacteriia 976|Bacteroidetes J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain alaS GO:0003674,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016597,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.7 ko:K01872 ko00970,map00970 M00359,M00360 R03038 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DHHA1,tRNA-synt_2c,tRNA_SAD k59_172615_2 1197477.IA57_02205 5.91e-27 106.0 COG0739@1|root,COG0739@2|Bacteria,4NGHH@976|Bacteroidetes,1HX46@117743|Flavobacteriia 976|Bacteroidetes M Peptidase, M23 mepM_1 - - - - - - - - - - - Peptidase_M23 k59_1245925_1 1121921.KB898706_gene3343 8.35e-89 273.0 COG0592@1|root,COG0592@2|Bacteria,1MVD9@1224|Proteobacteria,1RMNP@1236|Gammaproteobacteria,2PMSU@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria L DNA polymerase III beta subunit dnaN GO:0003674,GO:0003824,GO:0003887,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0022616,GO:0032991,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0042575,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0061695,GO:0071704,GO:0071897,GO:0090304,GO:0140097,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234 2.7.7.7 ko:K02338 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_beta,DNA_pol3_beta_2,DNA_pol3_beta_3 k59_1189207_1 1096930.L284_14710 2.34e-38 136.0 COG2116@1|root,COG2116@2|Bacteria,1N8YM@1224|Proteobacteria,2U0ZN@28211|Alphaproteobacteria,2K46U@204457|Sphingomonadales 204457|Sphingomonadales P Formate/nitrite transporter - - - ko:K21990 - - - - ko00000 1.A.16.4 - - Form_Nir_trans k59_1189207_2 1088721.NSU_2749 9.79e-53 167.0 COG2832@1|root,COG2832@2|Bacteria,1N7BI@1224|Proteobacteria,2UFAC@28211|Alphaproteobacteria,2K6I4@204457|Sphingomonadales 204457|Sphingomonadales S Protein of unknown function (DUF454) - - - ko:K09790 - - - - ko00000 - - - DUF454 k59_1754120_1 83406.HDN1F_09640 7.14e-22 93.6 COG1409@1|root,COG1409@2|Bacteria,1MWKX@1224|Proteobacteria,1RPA7@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes cpdA GO:0003674,GO:0003824,GO:0004112,GO:0004114,GO:0004115,GO:0005488,GO:0005506,GO:0008081,GO:0008150,GO:0008198,GO:0009987,GO:0016043,GO:0016787,GO:0016788,GO:0042545,GO:0042578,GO:0043167,GO:0043169,GO:0045229,GO:0046872,GO:0046914,GO:0071554,GO:0071555,GO:0071840 3.1.4.53 ko:K03651 ko00230,ko02025,map00230,map02025 - R00191 RC00296 ko00000,ko00001,ko01000 - - - Metallophos k59_1641290_1 946077.W5A_07517 2.22e-142 418.0 COG3507@1|root,COG3507@2|Bacteria,4NEMG@976|Bacteroidetes,1HYBD@117743|Flavobacteriia 976|Bacteroidetes G F5 8 type C domain - - - - - - - - - - - - F5_F8_type_C,Glyco_hydro_43 k59_1358853_1 864073.HFRIS_013940 1.1e-11 61.2 COG2919@1|root,COG2919@2|Bacteria,1N7AA@1224|Proteobacteria,2VVQJ@28216|Betaproteobacteria,474N3@75682|Oxalobacteraceae 28216|Betaproteobacteria D Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic ftsB - - ko:K05589 - - - - ko00000,ko03036 - - - DivIC k59_1358853_2 987059.RBXJA2T_12387 5.57e-73 231.0 COG0148@1|root,COG0148@2|Bacteria,1MU1N@1224|Proteobacteria,2VH7Y@28216|Betaproteobacteria,1KIVQ@119065|unclassified Burkholderiales 28216|Betaproteobacteria G Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis eno GO:0000015,GO:0000287,GO:0003674,GO:0003824,GO:0004634,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005856,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009986,GO:0009987,GO:0016052,GO:0016053,GO:0016310,GO:0016829,GO:0016835,GO:0016836,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0032991,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042802,GO:0042866,GO:0043167,GO:0043169,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046872,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1902494 4.2.1.11 ko:K01689 ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066 M00001,M00002,M00003,M00346,M00394 R00658 RC00349 ko00000,ko00001,ko00002,ko01000,ko03019,ko04147 - - - Enolase_C,Enolase_N k59_1697705_2 436308.Nmar_0214 2.19e-106 320.0 COG0044@1|root,arCOG00689@2157|Archaea,41S8A@651137|Thaumarchaeota 651137|Thaumarchaeota F Amidohydrolase family - - 3.5.2.2 ko:K01464 ko00240,ko00410,ko00770,ko00983,ko01100,map00240,map00410,map00770,map00983,map01100 M00046 R02269,R03055,R08227 RC00632,RC00680 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Amidohydro_1 k59_1358871_1 1122134.KB893651_gene2284 1.05e-48 164.0 COG0261@1|root,COG3743@1|root,COG0261@2|Bacteria,COG3743@2|Bacteria,1MZEW@1224|Proteobacteria,1S5VB@1236|Gammaproteobacteria,1XJZI@135619|Oceanospirillales 135619|Oceanospirillales J This protein binds to 23S rRNA in the presence of protein L20 rplU - - ko:K02888 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L21p k59_511252_2 1220583.GOACH_04_00770 1.5e-25 105.0 COG1228@1|root,COG1228@2|Bacteria,2GMUS@201174|Actinobacteria,4GCND@85026|Gordoniaceae 201174|Actinobacteria Q Amidohydrolase family - - - - - - - - - - - - Amidohydro_1 k59_228752_1 1128912.GMES_1465 2.47e-37 148.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,464D9@72275|Alteromonadaceae 1236|Gammaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family mdtB - - ko:K03296 - - - - ko00000 2.A.6.2 - - ACR_tran k59_511253_1 1144307.PMI04_02175 1.07e-107 323.0 COG4638@1|root,COG4638@2|Bacteria,1MWXW@1224|Proteobacteria 1224|Proteobacteria P phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases large terminal subunit - - - - - - - - - - - - Rieske,Ring_hydroxyl_A k59_285593_1 330214.NIDE2551 1.63e-112 340.0 COG0481@1|root,COG0481@2|Bacteria,3J0D1@40117|Nitrospirae 40117|Nitrospirae M Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner lepA - - ko:K03596 ko05134,map05134 - - - ko00000,ko00001 - - - EFG_C,GTP_EFTU,GTP_EFTU_D2,LepA_C k59_1641327_1 1123392.AQWL01000008_gene1188 1.2e-10 62.0 COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,2VKJ8@28216|Betaproteobacteria,1KSPP@119069|Hydrogenophilales 119069|Hydrogenophilales KLT Serine/Threonine protein kinases, catalytic domain - - - - - - - - - - - - Pkinase k59_1302469_1 316407.85676381 2.46e-80 250.0 COG0477@1|root,COG2814@2|Bacteria,1MVD0@1224|Proteobacteria,1RMBW@1236|Gammaproteobacteria,3XNMC@561|Escherichia 1236|Gammaproteobacteria U Involved in the efflux of purine ribonucleosides, such as guanosine, adenosine and especially inosine. Involved in the resistance to 6-mercaptopurine nepI GO:0003674,GO:0005215,GO:0005337,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0015211,GO:0015858,GO:0015860,GO:0015931,GO:0015932,GO:0016020,GO:0022857,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0072530,GO:1901264,GO:1901505,GO:1901642 - ko:K03445 - - - - ko00000,ko02000 2.A.1.2.26 - - MFS_1 k59_1302469_2 511145.b4555 3.29e-16 71.6 2D8BC@1|root,32TQY@2|Bacteria,1N3XB@1224|Proteobacteria,1SAN1@1236|Gammaproteobacteria,3XQ5W@561|Escherichia 1236|Gammaproteobacteria - - yicS - - - - - - - - - - - - k59_568031_1 316407.1736415 4.76e-23 91.3 COG2707@1|root,COG2707@2|Bacteria,1RA7I@1224|Proteobacteria,1S2D6@1236|Gammaproteobacteria,3XPKN@561|Escherichia 1236|Gammaproteobacteria S UPF0756 membrane protein YeaL yeaL GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - - - - - - - - - - DUF441 k59_568031_2 316407.85675120 9.21e-113 324.0 COG2606@1|root,COG2606@2|Bacteria,1R9YR@1224|Proteobacteria,1S27F@1236|Gammaproteobacteria,3XMST@561|Escherichia 1236|Gammaproteobacteria S Ser-tRNA(Ala) hydrolase activity yeaK GO:0002161,GO:0002196,GO:0003674,GO:0003824,GO:0006139,GO:0006399,GO:0006417,GO:0006450,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0016070,GO:0016787,GO:0016788,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0034248,GO:0034250,GO:0034641,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0045727,GO:0045903,GO:0046483,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0052689,GO:0060255,GO:0065007,GO:0065008,GO:0071704,GO:0080090,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360,GO:2000112 - ko:K19055 - - - - ko00000,ko01000,ko03016 - - - tRNA_edit k59_568031_3 199310.c2191 5.11e-46 161.0 COG2199@1|root,COG2199@2|Bacteria,1P3SE@1224|Proteobacteria,1SSZV@1236|Gammaproteobacteria,3XMW0@561|Escherichia 1236|Gammaproteobacteria T negative regulation of cell motility yeaJ GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0032879,GO:0040012,GO:0040013,GO:0044464,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051270,GO:0051271,GO:0065007,GO:0071944,GO:1902021,GO:1902201,GO:2000145,GO:2000146 - - - - - - - - - - GAF,GAPES1,GGDEF k59_398430_1 504472.Slin_3723 8.05e-15 82.0 2DDHA@1|root,2ZI3C@2|Bacteria,4P22R@976|Bacteroidetes 976|Bacteroidetes - - - - - - - - - - - - - - - k59_1245981_1 272568.GDI1751 1.91e-68 226.0 COG0578@1|root,COG0578@2|Bacteria,1MUMY@1224|Proteobacteria,2TU11@28211|Alphaproteobacteria,2JQAF@204441|Rhodospirillales 204441|Rhodospirillales C Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family glpD - 1.1.5.3 ko:K00111 ko00564,ko01110,map00564,map01110 - R00848 RC00029 ko00000,ko00001,ko01000 - - - DAO,DAO_C k59_172683_1 1122951.ATUE01000005_gene1668 2.5e-44 155.0 COG1560@1|root,COG1560@2|Bacteria,1MVNI@1224|Proteobacteria,1RMZ5@1236|Gammaproteobacteria,3NJM6@468|Moraxellaceae 1236|Gammaproteobacteria M Catalyzes the transfer of laurate from lauroyl-acyl carrier protein (ACP) to Kdo(2)-lipid IV(A) to form Kdo(2)- (lauroyl)-lipid IV(A) lpxL - 2.3.1.241 ko:K02517 ko00540,ko01100,map00540,map01100 M00060 R05146 RC00037,RC00039 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Lip_A_acyltrans k59_680745_1 247634.GPB2148_2436 2.26e-40 137.0 COG3788@1|root,COG3788@2|Bacteria,1NBHH@1224|Proteobacteria 1224|Proteobacteria S PFAM membrane-associated protein in eicosanoid and glutathione metabolism (MAPEG) - - 2.5.1.18 ko:K00799 ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418 - R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905 RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944 ko00000,ko00001,ko01000,ko02000 1.A.12.2.2,1.A.12.3.2 - - MAPEG k59_1705460_2 264730.PSPPH_4118 2.38e-21 92.0 COG0313@1|root,COG0313@2|Bacteria,1MU0E@1224|Proteobacteria,1RM7U@1236|Gammaproteobacteria,1Z67I@136849|Pseudomonas syringae group 1236|Gammaproteobacteria H Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA rsmI GO:0000154,GO:0000451,GO:0000453,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070677,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.198 ko:K07056 - - - - ko00000,ko01000,ko03009 - - - TP_methylase k59_970710_1 686340.Metal_2183 1.47e-71 231.0 COG0305@1|root,COG0305@2|Bacteria,1MUG9@1224|Proteobacteria,1RPM2@1236|Gammaproteobacteria,1XDRQ@135618|Methylococcales 135618|Methylococcales L it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins dnaB - 3.6.4.12 ko:K02314 ko03030,ko04112,map03030,map04112 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB,DnaB_C k59_858855_1 1131553.JIBI01000002_gene1803 5.57e-08 53.9 COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,2VJ9G@28216|Betaproteobacteria,37267@32003|Nitrosomonadales 28216|Betaproteobacteria O Belongs to the peptidase S1C family degQ - - ko:K04691,ko:K04772 - - - - ko00000,ko01000,ko01002 - - - PDZ_2,Trypsin_2 k59_858855_2 76114.ebA1198 3.8e-51 167.0 COG0723@1|root,COG0723@2|Bacteria,1RAA2@1224|Proteobacteria,2VK46@28216|Betaproteobacteria,2KVZE@206389|Rhodocyclales 206389|Rhodocyclales C Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis petA - 1.10.2.2 ko:K00411 ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016 M00151,M00152 - - ko00000,ko00001,ko00002,ko01000 - - - Rieske,UCR_Fe-S_N k59_1197295_1 316407.85676148 4.81e-128 374.0 COG0642@1|root,COG2205@2|Bacteria,1MUAK@1224|Proteobacteria,1RPDY@1236|Gammaproteobacteria,3XPHK@561|Escherichia 1236|Gammaproteobacteria T the biosynthesis of isoleucine and valine, the TraJ protein activation activity for tra gene expression in F plasmid, and the synthesis, translocation, or stability of cell envelope proteins. Activates cpxA GO:0000155,GO:0000160,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007155,GO:0007165,GO:0008150,GO:0008152,GO:0009314,GO:0009628,GO:0009987,GO:0016020,GO:0016021,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0022610,GO:0023014,GO:0023052,GO:0031224,GO:0031589,GO:0035556,GO:0036211,GO:0042710,GO:0042802,GO:0043170,GO:0043412,GO:0043708,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044464,GO:0044764,GO:0046777,GO:0050789,GO:0050794,GO:0050896,GO:0051704,GO:0051716,GO:0065007,GO:0071704,GO:0071944,GO:0090605,GO:0140096,GO:1901564 2.7.13.3 ko:K07640 ko01503,ko02020,map01503,map02020 M00447,M00727,M00728 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - CpxA_peri,HAMP,HATPase_c,HisKA k59_1197295_2 316407.85676149 4.02e-123 352.0 COG2258@1|root,COG2258@2|Bacteria,1RAPM@1224|Proteobacteria,1RRB8@1236|Gammaproteobacteria,3XMCD@561|Escherichia 1236|Gammaproteobacteria S toxin catabolic process yiiM GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0009056,GO:0009404,GO:0009407,GO:0009636,GO:0009987,GO:0019748,GO:0042221,GO:0044237,GO:0044248,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0098754 - - - - - - - - - - 3-alpha,MOSC k59_1480298_1 926569.ANT_01460 1.78e-73 232.0 COG1159@1|root,COG1159@2|Bacteria,2G69C@200795|Chloroflexi 200795|Chloroflexi S An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism era - - ko:K03595 - - - - ko00000,ko03009,ko03029 - - - KH_2,MMR_HSR1 k59_1084140_1 556269.ACDQ01000010_gene1888 2.23e-84 261.0 COG1448@1|root,COG1448@2|Bacteria,1MUT0@1224|Proteobacteria,2VHNH@28216|Betaproteobacteria,472KW@75682|Oxalobacteraceae 28216|Betaproteobacteria E Aminotransferase class I and II tyrB - 2.6.1.57 ko:K00832 ko00270,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01230,map00270,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01230 M00024,M00025,M00034,M00040 R00694,R00734,R01731,R07396,R10845 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 k59_970730_1 643562.Daes_0379 2.84e-22 94.7 COG2207@1|root,COG2207@2|Bacteria,1R81X@1224|Proteobacteria,42ZZ9@68525|delta/epsilon subdivisions,2WVB5@28221|Deltaproteobacteria,2MDXH@213115|Desulfovibrionales 28221|Deltaproteobacteria K PFAM helix-turn-helix- domain containing protein AraC type - - - ko:K04033,ko:K07506 - - - - ko00000,ko03000 - - - AraC_binding_2,HTH_18 k59_1705477_1 397945.Aave_1152 9.47e-39 150.0 COG2202@1|root,COG5001@1|root,COG2202@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,4A9PA@80864|Comamonadaceae 28216|Betaproteobacteria T Diguanylate cyclase - - - - - - - - - - - - EAL,GAF_2,GGDEF,MASE3,PAS_3,PAS_4,PAS_7,PAS_9 k59_1422874_1 44056.XP_009032446.1 4e-24 106.0 COG2114@1|root,2QPPT@2759|Eukaryota 2759|Eukaryota T Adenylate cyclase - - 4.6.1.1 ko:K11265 ko00230,ko04024,ko04371,ko04713,ko04714,map00230,map04024,map04371,map04713,map04714 - R00089,R00434 RC00295 ko00000,ko00001,ko01000 - - - AAA_16,Guanylate_cyc,PH k59_802125_1 314278.NB231_11479 3.32e-108 320.0 COG2513@1|root,COG2513@2|Bacteria,1N4VT@1224|Proteobacteria,1RMR5@1236|Gammaproteobacteria,1WWC7@135613|Chromatiales 135613|Chromatiales G Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate prpB - 4.1.3.30 ko:K03417 ko00640,map00640 - R00409 RC00286,RC00287 ko00000,ko00001,ko01000 - - - PEP_mutase k59_236508_1 1122929.KB908224_gene3478 4.19e-90 275.0 COG0079@1|root,COG0079@2|Bacteria,1MW7I@1224|Proteobacteria,2TQPN@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily hisC - 2.6.1.9 ko:K00817 ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230 M00026 R00694,R00734,R03243 RC00006,RC00888 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 k59_1084149_1 1177181.T9A_02166 8.52e-90 285.0 COG0855@1|root,COG0855@2|Bacteria,1MUM3@1224|Proteobacteria,1RNRX@1236|Gammaproteobacteria,1XHXZ@135619|Oceanospirillales 135619|Oceanospirillales H Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) ppk - 2.7.4.1 ko:K00937 ko00190,ko03018,map00190,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - PP_kinase,PP_kinase_C,PP_kinase_N k59_236512_2 1229909.NSED_07370 3.42e-36 124.0 COG1522@1|root,arCOG01117@2157|Archaea 1229909.NSED_07370|- K COG1522 Transcriptional regulators - - - - - - - - - - - - - k59_406233_1 266117.Rxyl_1975 1.04e-121 363.0 COG0001@1|root,COG0001@2|Bacteria,2GJSH@201174|Actinobacteria,4CPG9@84995|Rubrobacteria 84995|Rubrobacteria H Aminotransferase class-III hemL - 5.4.3.8 ko:K01845 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R02272 RC00677 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 k59_632108_1 305900.GV64_10655 8.6e-103 308.0 COG0826@1|root,COG0826@2|Bacteria,1MUQG@1224|Proteobacteria,1RP6X@1236|Gammaproteobacteria,1XHDC@135619|Oceanospirillales 135619|Oceanospirillales O Peptidase family U32 yhbU - - ko:K08303 ko05120,map05120 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_U32 k59_1197311_2 279238.Saro_0666 9.54e-82 246.0 COG3926@1|root,COG3926@2|Bacteria,1MVXW@1224|Proteobacteria,2U8FG@28211|Alphaproteobacteria,2K3X0@204457|Sphingomonadales 204457|Sphingomonadales S secretion activating protein - - - - - - - - - - - - Glyco_hydro_108,PG_binding_3 k59_1366976_1 448385.sce1617 2.63e-34 135.0 COG0457@1|root,COG0515@1|root,COG3899@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,COG3899@2|Bacteria,1QA6R@1224|Proteobacteria,4393M@68525|delta/epsilon subdivisions,2X49J@28221|Deltaproteobacteria,2YYJG@29|Myxococcales 28221|Deltaproteobacteria KLT Family membership - - - - - - - - - - - - AAA_16,Pkinase k59_1592390_1 1144305.PMI02_01755 6.96e-92 293.0 COG0243@1|root,COG0243@2|Bacteria,1NS3T@1224|Proteobacteria,2TQYD@28211|Alphaproteobacteria,2K1FR@204457|Sphingomonadales 204457|Sphingomonadales C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - - ko:K00372 ko00910,ko01120,map00910,map01120 M00531 R00798,R01106 RC02812 ko00000,ko00001,ko00002,ko01000 - - - Fer2_BFD,Molybdop_Fe4S4,Molybdopterin,Molydop_binding k59_1366986_1 1121937.AUHJ01000017_gene3012 1.48e-12 72.0 2EDVS@1|root,337QX@2|Bacteria,1NEZW@1224|Proteobacteria,1SCKV@1236|Gammaproteobacteria,46C7E@72275|Alteromonadaceae 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_1084171_1 159087.Daro_1151 1.76e-114 347.0 COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,2VHQ1@28216|Betaproteobacteria,2KV9Y@206389|Rhodocyclales 206389|Rhodocyclales NU Type II secretion system (T2SS), protein E, N-terminal domain - - - ko:K02454 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - T2SSE,T2SSE_N k59_1028611_1 402626.Rpic_3489 6.47e-101 321.0 COG0403@1|root,COG1003@1|root,COG0403@2|Bacteria,COG1003@2|Bacteria,1MUDP@1224|Proteobacteria,2VHQ6@28216|Betaproteobacteria,1K105@119060|Burkholderiaceae 28216|Betaproteobacteria E The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor gcvP - 1.4.4.2 ko:K00281 ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200 M00532 R01221,R03425 RC00022,RC00929,RC02834,RC02880 ko00000,ko00001,ko00002,ko01000 - - - GDC-P k59_1762139_1 333138.LQ50_18330 5.28e-22 95.9 COG1670@1|root,COG1670@2|Bacteria,1V2FI@1239|Firmicutes,4HFU6@91061|Bacilli,1ZRCR@1386|Bacillus 91061|Bacilli J Acetyltransferase (GNAT) domain - - 2.3.1.128 ko:K03790 - - - - ko00000,ko01000,ko03009 - - - Acetyltransf_3 k59_1592407_1 287.DR97_3610 1.04e-42 156.0 COG0464@1|root,COG0464@2|Bacteria,1MW4T@1224|Proteobacteria,1RPUI@1236|Gammaproteobacteria,1YEX1@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria O ATPase family associated with various cellular activities (AAA) - - - - - - - - - - - - AAA k59_124076_1 1500893.JQNB01000001_gene1418 6.59e-06 51.2 COG0642@1|root,COG2205@2|Bacteria,1N17V@1224|Proteobacteria,1RNFK@1236|Gammaproteobacteria,1X4YC@135614|Xanthomonadales 135614|Xanthomonadales T Histidine kinase - - - - - - - - - - - - HATPase_c,HisKA k59_124076_2 1121935.AQXX01000126_gene957 4.25e-36 128.0 COG0745@1|root,COG0745@2|Bacteria,1MVCB@1224|Proteobacteria,1RM87@1236|Gammaproteobacteria,1XNQA@135619|Oceanospirillales 135619|Oceanospirillales T Transcriptional regulatory protein, C terminal - - - ko:K02483 - - - - ko00000,ko02022 - - - Response_reg,Trans_reg_C k59_67958_1 401053.AciPR4_2017 6.27e-24 103.0 COG0624@1|root,COG0624@2|Bacteria,3Y2XS@57723|Acidobacteria,2JINN@204432|Acidobacteriia 204432|Acidobacteriia E Peptidase, M20 - - - - - - - - - - - - M20_dimer,Peptidase_M20,Peptidase_M28 k59_350279_1 402881.Plav_0175 6.93e-65 227.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2TQT0@28211|Alphaproteobacteria,1JN93@119043|Rhodobiaceae 28211|Alphaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K03296,ko:K18138 ko01501,ko01503,map01501,map01503 M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000 2.A.6.2 - - ACR_tran k59_688798_1 765952.PUV_02240 1.95e-38 145.0 COG2327@1|root,COG2327@2|Bacteria 2|Bacteria S slime layer polysaccharide biosynthetic process - - - ko:K16710 - - - - ko00000 - - - PS_pyruv_trans,Radical_SAM k59_1536323_1 1192034.CAP_1485 7.75e-39 151.0 COG1366@1|root,COG3899@1|root,COG4191@1|root,COG1366@2|Bacteria,COG3899@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria 1224|Proteobacteria T Histidine kinase - - - - - - - - - - - - AAA_16,GAF,GAF_2,HATPase_c,HisKA,PAS_3,PAS_8,PAS_9,Pkinase k59_1367020_1 983920.Y88_0396 6.86e-97 288.0 COG1738@1|root,COG1738@2|Bacteria,1NIPE@1224|Proteobacteria,2TTZV@28211|Alphaproteobacteria,2K1FS@204457|Sphingomonadales 204457|Sphingomonadales S Involved in the import of queuosine (Q) precursors, required for Q precursor salvage - - - ko:K09125 - - - - ko00000 - - - Vut_1 k59_1367020_2 555793.WSK_4094 1.4e-23 97.4 COG1195@1|root,COG1195@2|Bacteria,1MX8N@1224|Proteobacteria,2TQRD@28211|Alphaproteobacteria,2K0WV@204457|Sphingomonadales 204457|Sphingomonadales L it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP recF - - ko:K03629 ko03440,map03440 - - - ko00000,ko00001,ko03400 - - - SMC_N k59_1592437_1 592028.GCWU000321_01923 1.61e-39 148.0 COG1804@1|root,COG1804@2|Bacteria,1TP54@1239|Firmicutes,4H3KD@909932|Negativicutes 909932|Negativicutes C III protein - - - - - - - - - - - - CoA_transf_3 k59_802177_1 269800.Tfu_0417 2.94e-32 120.0 COG0193@1|root,COG0193@2|Bacteria,2GKCV@201174|Actinobacteria,4EIGM@85012|Streptosporangiales 201174|Actinobacteria J The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis pth GO:0003674,GO:0003824,GO:0004045,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0016787,GO:0016788,GO:0040007,GO:0044464,GO:0052689,GO:0071944,GO:0140098,GO:0140101 3.1.1.29 ko:K01056 - - - - ko00000,ko01000,ko03012 - - - Pept_tRNA_hydro k59_802177_2 106582.XP_004571288.1 6.06e-05 45.4 COG0554@1|root,KOG2517@2759|Eukaryota,38DGY@33154|Opisthokonta,3B9PY@33208|Metazoa,3CVSP@33213|Bilateria,486H2@7711|Chordata,497B3@7742|Vertebrata,49XDI@7898|Actinopterygii 33208|Metazoa G glycerol GK GO:0003674,GO:0003824,GO:0004370,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005739,GO:0005740,GO:0005741,GO:0005829,GO:0005975,GO:0006066,GO:0006071,GO:0006072,GO:0006629,GO:0006638,GO:0006639,GO:0006641,GO:0006793,GO:0006796,GO:0006950,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009266,GO:0009409,GO:0009628,GO:0009636,GO:0009987,GO:0010033,GO:0010565,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019216,GO:0019217,GO:0019222,GO:0019400,GO:0019432,GO:0019637,GO:0019751,GO:0019867,GO:0031090,GO:0031323,GO:0031966,GO:0031967,GO:0031968,GO:0031975,GO:0033500,GO:0042221,GO:0042393,GO:0042493,GO:0042592,GO:0042593,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044262,GO:0044281,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0045017,GO:0045471,GO:0046167,GO:0046460,GO:0046463,GO:0046486,GO:0046677,GO:0048878,GO:0050789,GO:0050794,GO:0050896,GO:0052646,GO:0062012,GO:0065007,GO:0065008,GO:0071704,GO:0080090,GO:0090407,GO:0097305,GO:0098588,GO:0098805,GO:1901135,GO:1901137,GO:1901576,GO:1901615,GO:1901700 2.7.1.30 ko:K00864 ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626 - R00847 RC00002,RC00017 ko00000,ko00001,ko01000,ko04147 - - - FGGY_C,FGGY_N k59_519029_1 243233.MCA2048 1.16e-25 103.0 COG2084@1|root,COG2084@2|Bacteria,1MUGU@1224|Proteobacteria,1RQ2D@1236|Gammaproteobacteria,1XEAH@135618|Methylococcales 135618|Methylococcales I NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase - - - - - - - - - - - - NAD_binding_11,NAD_binding_2 k59_11165_1 1384056.N787_07055 3.78e-65 214.0 COG0348@1|root,COG0348@2|Bacteria,1MVFY@1224|Proteobacteria,1RMDI@1236|Gammaproteobacteria,1X4FV@135614|Xanthomonadales 135614|Xanthomonadales C IG-like fold at C-terminal of FixG, putative oxidoreductase - - - - - - - - - - - - Fer4_18,Fer4_5,FixG_C k59_11165_2 396588.Tgr7_0635 2.79e-11 61.6 2EFX9@1|root,339PI@2|Bacteria,1NI0D@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_11165_3 1005395.CSV86_05851 2.89e-12 69.7 COG2010@1|root,COG2010@2|Bacteria,1MUCW@1224|Proteobacteria,1RPYJ@1236|Gammaproteobacteria 1236|Gammaproteobacteria C C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex ccoP - - ko:K00406 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00156 - - ko00000,ko00001,ko00002 3.D.4.3 - - Cytochrome_CBB3,FixP_N k59_1310472_2 871963.Desdi_2949 1.01e-05 50.8 COG3279@1|root,COG3279@2|Bacteria,1TRDQ@1239|Firmicutes,24FJV@186801|Clostridia,264MR@186807|Peptococcaceae 186801|Clostridia T Response regulator of the LytR AlgR family - - - - - - - - - - - - LytTR,Response_reg k59_858895_2 1123250.KB908382_gene1218 3.9e-06 52.0 COG0768@1|root,COG0768@2|Bacteria,1TP93@1239|Firmicutes,4H207@909932|Negativicutes 909932|Negativicutes M Penicillin-binding protein, transpeptidase domain protein ftsI - 3.4.16.4 ko:K03587,ko:K08384 ko00550,ko01501,map00550,map01501 - - - ko00000,ko00001,ko01000,ko01011,ko03036 - - - PASTA,PBP_dimer,Transpeptidase k59_1536339_1 1168034.FH5T_06455 5.21e-26 104.0 COG1402@1|root,COG1402@2|Bacteria,4NF2C@976|Bacteroidetes,2FNIV@200643|Bacteroidia 976|Bacteroidetes S Creatinine amidohydrolase crnA - 3.5.2.10 ko:K01470 ko00330,map00330 - R01884 RC00615 ko00000,ko00001,ko01000 - - - Creatininase k59_1536339_2 626887.J057_13241 3.69e-13 65.9 COG2329@1|root,COG2329@2|Bacteria,1N2ZS@1224|Proteobacteria 1224|Proteobacteria S Antibiotic biosynthesis monooxygenase - - - - - - - - - - - - - k59_462886_1 756272.Plabr_1495 9e-87 263.0 COG0288@1|root,COG0288@2|Bacteria,2IWW6@203682|Planctomycetes 203682|Planctomycetes P Reversible hydration of carbon dioxide - - 4.2.1.1 ko:K01673 ko00910,map00910 - R00132,R10092 RC02807 ko00000,ko00001,ko01000 - - - Pro_CA k59_462886_2 1247963.JPHU01000006_gene120 2.44e-38 145.0 COG0659@1|root,COG0659@2|Bacteria,1MVWV@1224|Proteobacteria,2U0W9@28211|Alphaproteobacteria 28211|Alphaproteobacteria P COG0659 Sulfate permease and related transporters (MFS superfamily) - - - - - - - - - - - - STAS,Sulfate_transp k59_1422939_1 247639.MGP2080_11448 7.86e-73 233.0 COG3067@1|root,COG3067@2|Bacteria,1MV0F@1224|Proteobacteria,1RPE3@1236|Gammaproteobacteria,1J506@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P Na( ) H( ) antiporter that extrudes sodium in exchange for external protons nhaB GO:0003674,GO:0005215,GO:0005451,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006814,GO:0006873,GO:0006885,GO:0008150,GO:0008324,GO:0009987,GO:0010035,GO:0010038,GO:0010226,GO:0015075,GO:0015077,GO:0015078,GO:0015081,GO:0015291,GO:0015297,GO:0015298,GO:0015299,GO:0015318,GO:0015385,GO:0015491,GO:0015672,GO:0016020,GO:0019725,GO:0022804,GO:0022857,GO:0022890,GO:0030001,GO:0030003,GO:0030004,GO:0030641,GO:0034220,GO:0035725,GO:0042221,GO:0042592,GO:0044464,GO:0045851,GO:0046873,GO:0048878,GO:0050801,GO:0050896,GO:0051179,GO:0051234,GO:0051452,GO:0051453,GO:0055067,GO:0055080,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:0098771,GO:0099516,GO:1902600 - ko:K03314 - - - - ko00000,ko02000 2.A.34.1 - iECP_1309.ECP_1229,iLF82_1304.LF82_1485,iNRG857_1313.NRG857_06055,iUTI89_1310.UTI89_C1372 NhaB k59_575625_1 436308.Nmar_0369 4.45e-141 406.0 COG1063@1|root,arCOG01459@2157|Archaea 2157|Archaea C Catalyzes the NAD(P)( )-dependent oxidation of D-glucose to D-gluconate via gluconolactone. Can utilize both NAD( ) and NADP( ) as electron acceptor. Is involved in the degradation of glucose through a - - 1.1.1.1 ko:K00001 ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220 - R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310 RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273 ko00000,ko00001,ko01000 - - - ADH_N,ADH_zinc_N,Glu_dehyd_C k59_293769_1 436308.Nmar_1719 2.35e-95 284.0 COG1701@1|root,arCOG04262@2157|Archaea,41SXP@651137|Thaumarchaeota 651137|Thaumarchaeota S Pfam:DUF137 - - 6.3.2.36 ko:K09722 ko00410,ko00770,ko01100,map00410,map00770,map01100 - R09379 RC00096,RC00141 ko00000,ko00001,ko01000 - - - PPS_PS k59_293769_2 436308.Nmar_1718 5.21e-23 95.9 COG1829@1|root,arCOG04263@2157|Archaea,41T1V@651137|Thaumarchaeota 651137|Thaumarchaeota S kinase, sugar kinase superfamily - - 2.7.1.169 ko:K06982 ko00770,ko01100,map00770,map01100 - R09378 RC00002,RC00017 ko00000,ko00001,ko01000 - - - GHMP_kinases_N k59_519043_1 338963.Pcar_3048 1.73e-08 53.9 2A70U@1|root,30VW1@2|Bacteria,1RGBZ@1224|Proteobacteria,42VYK@68525|delta/epsilon subdivisions,2WSFU@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Glyoxalase-like domain - - - - - - - - - - - - Glyoxalase_3 k59_519043_2 1379270.AUXF01000001_gene2158 8.85e-20 92.4 2AC8C@1|root,311T1@2|Bacteria,1ZU75@142182|Gemmatimonadetes 142182|Gemmatimonadetes - - - - - - - - - - - - - - - k59_1367065_1 436308.Nmar_0194 5.61e-112 332.0 COG1819@1|root,arCOG01393@2157|Archaea,41T16@651137|Thaumarchaeota 651137|Thaumarchaeota G Glycosyltransferase family 28 C-terminal domain - - - - - - - - - - - - Glyco_tran_28_C k59_1592472_1 522306.CAP2UW1_4071 5.49e-58 201.0 COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,2VH2F@28216|Betaproteobacteria,1KQ71@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria P Cation transporter/ATPase, N-terminus - - 3.6.3.8 ko:K01537 - - - - ko00000,ko01000 3.A.3.2 - - Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3 k59_11196_1 247634.GPB2148_347 1.44e-05 53.1 COG0457@1|root,COG0457@2|Bacteria,1MVMG@1224|Proteobacteria,1RU5N@1236|Gammaproteobacteria 1236|Gammaproteobacteria K COG0457 FOG TPR repeat - - - - - - - - - - - - Sulfotransfer_3,TPR_16,TPR_19,TPR_8 k59_802208_1 95619.PM1_0200995 2.03e-72 221.0 COG1327@1|root,COG1327@2|Bacteria,1RE7V@1224|Proteobacteria,1S3P9@1236|Gammaproteobacteria 1236|Gammaproteobacteria K Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes nrdR GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0005488,GO:0005524,GO:0006355,GO:0008144,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0017076,GO:0019219,GO:0019222,GO:0030554,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 - ko:K07738 - - - - ko00000,ko03000 - - - ATP-cone k59_1367072_1 1163617.SCD_n01806 2.46e-10 60.8 COG1520@1|root,COG1520@2|Bacteria,1MXIJ@1224|Proteobacteria,2VHH5@28216|Betaproteobacteria 28216|Betaproteobacteria M Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane bamB - - ko:K17713 - - - - ko00000,ko02000 1.B.33.1 - - PQQ_2,PQQ_3 k59_294632_1 179408.Osc7112_6159 4.18e-40 151.0 COG0642@1|root,COG0683@1|root,COG0745@1|root,COG5000@1|root,COG0642@2|Bacteria,COG0683@2|Bacteria,COG0745@2|Bacteria,COG5000@2|Bacteria,1G1VR@1117|Cyanobacteria,1HH4J@1150|Oscillatoriales 1117|Cyanobacteria T Signal transduction histidine kinase, subgroup 1, dimerisation phosphoacceptor domain - - - ko:K11959 ko02010,map02010 M00323 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4.4,3.A.1.4.5 - - HATPase_c,HisKA,Peripla_BP_5,Response_reg k59_802919_1 685778.AORL01000009_gene3313 3.69e-35 135.0 COG5610@1|root,COG5610@2|Bacteria,1Q4T5@1224|Proteobacteria,2U1E1@28211|Alphaproteobacteria,2K38J@204457|Sphingomonadales 204457|Sphingomonadales S Hydrolase - - - - - - - - - - - - HAD_2 k59_1537132_1 1532557.JL37_01655 6.41e-71 222.0 COG0501@1|root,COG0501@2|Bacteria,1MUNA@1224|Proteobacteria,2VHTB@28216|Betaproteobacteria,3T1FP@506|Alcaligenaceae 28216|Betaproteobacteria M Zn-dependent protease with chaperone function - - - - - - - - - - - - Peptidase_M48 k59_915340_1 1121127.JAFA01000004_gene1234 2.1e-21 101.0 COG0642@1|root,COG2205@2|Bacteria,1N1Z2@1224|Proteobacteria,2VR4B@28216|Betaproteobacteria,1KGIE@119060|Burkholderiaceae 28216|Betaproteobacteria T Histidine kinase - - 2.7.13.3 ko:K02484,ko:K07645 ko02020,ko02024,map02020,map02024 M00453 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA k59_859755_1 316407.85676643 3.99e-107 328.0 28IJR@1|root,2Z8KK@2|Bacteria,1N39T@1224|Proteobacteria,1RN16@1236|Gammaproteobacteria,3XN1H@561|Escherichia 1236|Gammaproteobacteria S Intracellular growth attenuator protein IgaA yrfF GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - - - - - - - - - - IgaA k59_68795_1 1122201.AUAZ01000002_gene854 8.62e-53 190.0 COG0553@1|root,COG0553@2|Bacteria,1MX6H@1224|Proteobacteria,1RNRZ@1236|Gammaproteobacteria,464KJ@72275|Alteromonadaceae 1236|Gammaproteobacteria K Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair rapA GO:0000166,GO:0001000,GO:0003674,GO:0003676,GO:0003824,GO:0004386,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0019899,GO:0030554,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032553,GO:0032555,GO:0032559,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043175,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0045893,GO:0045935,GO:0046483,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0070063,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097367,GO:0097659,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141 - ko:K03580 - - - - ko00000,ko01000,ko03021 - - - Helicase_C,RapA_C,SNF2_N k59_1311291_2 526225.Gobs_2965 1.31e-32 125.0 COG0508@1|root,COG1249@1|root,COG0508@2|Bacteria,COG1249@2|Bacteria,2GIXY@201174|Actinobacteria 201174|Actinobacteria C Dehydrogenase lpdA_1 - 1.8.1.4 ko:K00382 ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00036,M00307,M00532 R00209,R01221,R01698,R03815,R07618,R08549 RC00004,RC00022,RC00583,RC02742,RC02833,RC02834 br01601,ko00000,ko00001,ko00002,ko01000,ko04147 - - - Biotin_lipoyl,Pyr_redox_2,Pyr_redox_dim k59_68806_1 1121011.AUCB01000040_gene3429 8.54e-95 304.0 COG3696@1|root,COG3696@2|Bacteria,4P36A@976|Bacteroidetes,1IJ7V@117743|Flavobacteriia,23GJZ@178469|Arenibacter 976|Bacteroidetes P AcrB/AcrD/AcrF family - - - ko:K07787,ko:K15726 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.6.1.2,2.A.6.1.4 - - ACR_tran k59_632909_1 1121904.ARBP01000009_gene4188 7.08e-213 600.0 COG0715@1|root,COG0715@2|Bacteria,4NGQ6@976|Bacteroidetes,47KV3@768503|Cytophagia 976|Bacteroidetes P NMT1-like family - - - ko:K15576 ko00910,ko02010,map00910,map02010 M00438 - - ko00000,ko00001,ko00002,ko02000 3.A.1.16.1,3.A.1.16.2 - - NMT1_2 k59_407101_1 1123279.ATUS01000003_gene561 3.02e-136 401.0 COG0119@1|root,COG0119@2|Bacteria,1MUNQ@1224|Proteobacteria,1RMWE@1236|Gammaproteobacteria,1J4FM@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) leuA GO:0003674,GO:0003824,GO:0003852,GO:0003985,GO:0003988,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009987,GO:0016053,GO:0016407,GO:0016408,GO:0016453,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046912,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.3.3.13 ko:K01649 ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230 M00432 R01213 RC00004,RC00470,RC02754 br01601,ko00000,ko00001,ko00002,ko01000 - - iSFV_1184.SFV_0066 HMGL-like,LeuA_dimer k59_68810_1 1163617.SCD_n02706 6.41e-71 229.0 COG1797@1|root,COG1797@2|Bacteria,1MV7Z@1224|Proteobacteria,2VI93@28216|Betaproteobacteria 28216|Betaproteobacteria H Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source cbiA - 6.3.5.11,6.3.5.9 ko:K02224 ko00860,ko01100,ko01120,map00860,map01100,map01120 - R05224,R05815 RC00010,RC01301 ko00000,ko00001,ko01000 - - - AAA_26,CbiA,GATase_3 k59_1311303_1 351348.Maqu_0973 2.49e-112 352.0 COG0587@1|root,COG0587@2|Bacteria,1MUE4@1224|Proteobacteria,1RQA8@1236|Gammaproteobacteria,464B5@72275|Alteromonadaceae 1236|Gammaproteobacteria L DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase dnaE2 GO:0003674,GO:0003824,GO:0003887,GO:0006139,GO:0006259,GO:0006260,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0071704,GO:0071897,GO:0090304,GO:0140097,GO:1901360,GO:1901362,GO:1901576 2.7.7.7 ko:K14162 - - - - ko00000,ko01000,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon k59_1593392_1 517418.Ctha_2689 3.04e-24 102.0 COG1104@1|root,COG1104@2|Bacteria,1FDUZ@1090|Chlorobi 1090|Chlorobi E PFAM aminotransferase class V iscS - 2.8.1.7 ko:K04487 ko00730,ko01100,ko04122,map00730,map01100,map04122 - R07460,R11528,R11529 RC01789,RC02313 ko00000,ko00001,ko01000,ko02048,ko03016,ko03029 - - - Aminotran_5 k59_1593392_2 1042209.HK44_000245 3.25e-12 66.2 COG1397@1|root,COG1397@2|Bacteria,1NTUR@1224|Proteobacteria,1RMPE@1236|Gammaproteobacteria,1YPWK@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria O ADP-ribosylglycohydrolase draG - 3.2.2.24 ko:K05521 - - - - ko00000,ko01000 - - - ADP_ribosyl_GH k59_695592_1 1051632.TPY_0198 9.32e-66 225.0 COG1197@1|root,COG1197@2|Bacteria,1TPF1@1239|Firmicutes,248D8@186801|Clostridia,3WCCX@538999|Clostridiales incertae sedis 186801|Clostridia L Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site mfd - - ko:K03723 ko03420,map03420 - - - ko00000,ko00001,ko01000,ko03400 - - - CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF k59_1035711_2 1219035.NT2_06_01550 1.6e-36 130.0 COG4659@1|root,COG4659@2|Bacteria,1RFGW@1224|Proteobacteria,2U55M@28211|Alphaproteobacteria,2K5DF@204457|Sphingomonadales 204457|Sphingomonadales C FMN_bind - - - - - - - - - - - - FMN_bind k59_1260335_1 555793.WSK_1750 3.1e-80 246.0 COG2086@1|root,COG2086@2|Bacteria,1MVH6@1224|Proteobacteria,2TSQX@28211|Alphaproteobacteria 28211|Alphaproteobacteria C Electron transfer flavoprotein fixA GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009987,GO:0016491,GO:0022900,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0055114 - ko:K03521 - - - - ko00000 - - - ETF k59_1260335_2 983920.Y88_3391 7.28e-06 47.4 COG2025@1|root,COG2025@2|Bacteria,1MUFI@1224|Proteobacteria,2TR10@28211|Alphaproteobacteria,2K1AU@204457|Sphingomonadales 204457|Sphingomonadales C Electron transfer flavoprotein - - - - - - - - - - - - ETF,ETF_alpha k59_187779_2 552398.HMPREF0866_01486 2.49e-26 108.0 COG0484@1|root,COG0484@2|Bacteria,1TP00@1239|Firmicutes,248EM@186801|Clostridia,3WH82@541000|Ruminococcaceae 186801|Clostridia O ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins dnaJ - - ko:K03686,ko:K05516 - - - - ko00000,ko03029,ko03036,ko03110 - - - DnaJ,DnaJ_C,DnaJ_CXXCXGXG k59_639215_1 746697.Aeqsu_0910 4.83e-102 302.0 COG2850@1|root,COG2850@2|Bacteria,4NEJI@976|Bacteroidetes,1HWP6@117743|Flavobacteriia 976|Bacteroidetes S Cupin-like domain - - - - - - - - - - - - Cupin_8 k59_809076_1 59538.XP_005971351.1 5.69e-92 292.0 COG0443@1|root,KOG0102@2759|Eukaryota,38EJA@33154|Opisthokonta,3BABY@33208|Metazoa,3CT5K@33213|Bilateria,48BEX@7711|Chordata,48XVF@7742|Vertebrata,3JAJ8@40674|Mammalia,4IZNM@91561|Cetartiodactyla 2759|Eukaryota O Heat shock 70 kDa protein - GO:0000166,GO:0000988,GO:0000989,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005829,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008144,GO:0008150,GO:0008270,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010033,GO:0010556,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0016989,GO:0017076,GO:0017111,GO:0019219,GO:0019222,GO:0022607,GO:0030554,GO:0031323,GO:0031326,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033554,GO:0034620,GO:0035639,GO:0035966,GO:0035967,GO:0036094,GO:0042221,GO:0043167,GO:0043168,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043531,GO:0043933,GO:0044085,GO:0044183,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0051171,GO:0051252,GO:0051716,GO:0060255,GO:0061077,GO:0065003,GO:0065007,GO:0070887,GO:0071310,GO:0071840,GO:0080090,GO:0097159,GO:0097367,GO:0140110,GO:1901265,GO:1901363,GO:1903506,GO:2001141 - ko:K04043 ko03018,ko04212,ko05152,map03018,map04212,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 1.A.33.1 - - HSP70 k59_921649_2 641526.ADIWIN_3924 7.03e-49 160.0 COG0697@1|root,COG0697@2|Bacteria,4NDYH@976|Bacteroidetes,1HXMM@117743|Flavobacteriia 976|Bacteroidetes EG EamA-like transporter family sam - - ko:K15270 - - - - ko00000,ko02000 2.A.7.3.7 - - EamA k59_1769014_1 1137281.D778_00205 3.42e-108 324.0 COG4591@1|root,COG4591@2|Bacteria,4NFWZ@976|Bacteroidetes,1HWT5@117743|Flavobacteriia 976|Bacteroidetes M ABC-type transport system involved in lipoprotein release permease component lolE_1 - - ko:K09808 ko02010,map02010 M00255 - - ko00000,ko00001,ko00002,ko02000 3.A.1.125 - - FtsX,MacB_PCD k59_1090972_2 257310.BB2628 2.22e-45 152.0 COG2867@1|root,COG2867@2|Bacteria,1RGUH@1224|Proteobacteria,2VR4X@28216|Betaproteobacteria,3T3I7@506|Alcaligenaceae 28216|Betaproteobacteria I oligoketide cyclase lipid transport protein ratA - - - - - - - - - - - Polyketide_cyc k59_1090972_3 1278307.KB906996_gene2992 3.37e-16 79.7 COG0733@1|root,COG0733@2|Bacteria,1MUZJ@1224|Proteobacteria,1RPCT@1236|Gammaproteobacteria,2QISB@267894|Psychromonadaceae 1236|Gammaproteobacteria S Sodium:neurotransmitter symporter family - - - ko:K03308 - - - - ko00000 2.A.22.4,2.A.22.5 - - SNF k59_1147402_1 1198232.CYCME_0500 6.14e-42 156.0 COG0116@1|root,COG1092@1|root,COG0116@2|Bacteria,COG1092@2|Bacteria,1MUQM@1224|Proteobacteria,1RNMH@1236|Gammaproteobacteria,46089@72273|Thiotrichales 72273|Thiotrichales J Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA rlmL - 2.1.1.173,2.1.1.264 ko:K12297 - - R07234 RC00003 ko00000,ko01000,ko03009 - - - Methyltrans_SAM,THUMP,UPF0020 k59_1374183_1 1124991.MU9_656 3.63e-12 65.5 COG0242@1|root,COG0242@2|Bacteria,1RA2P@1224|Proteobacteria,1S247@1236|Gammaproteobacteria 1236|Gammaproteobacteria J Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions - - 3.5.1.88 ko:K01462 - - - - ko00000,ko01000 - - - Pep_deformylase k59_1374183_2 1049564.TevJSym_ai00150 2.45e-29 110.0 COG2716@1|root,COG2716@2|Bacteria,1RB6J@1224|Proteobacteria,1S2A4@1236|Gammaproteobacteria 1236|Gammaproteobacteria E PFAM Amino acid-binding ACT - - - ko:K03567 ko02026,map02026 - - - ko00000,ko00001,ko03000 - - - ACT_6 k59_75187_1 522306.CAP2UW1_0644 7.1e-51 168.0 COG1058@1|root,COG1058@2|Bacteria,1MVG6@1224|Proteobacteria,2VHTD@28216|Betaproteobacteria,1KQMS@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria S Probable molybdopterin binding domain yfaY - - - - - - - - - - - MoCF_biosynth k59_75187_2 1123392.AQWL01000005_gene2883 7.47e-19 85.1 COG2981@1|root,COG2981@2|Bacteria,1Q181@1224|Proteobacteria,2VN29@28216|Betaproteobacteria,1KRR8@119069|Hydrogenophilales 119069|Hydrogenophilales E Etoposide-induced protein 2.4 (EI24) - - - - - - - - - - - - EI24 k59_695608_1 882086.SacxiDRAFT_1968 2.53e-19 90.5 COG2518@1|root,COG2518@2|Bacteria,2GJ3I@201174|Actinobacteria,4E11S@85010|Pseudonocardiales 201174|Actinobacteria O Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) - - - - - - - - - - - - PCMT k59_695608_2 436308.Nmar_0312 2.74e-19 85.9 COG0142@1|root,arCOG01726@2157|Archaea,41SEV@651137|Thaumarchaeota 651137|Thaumarchaeota H Belongs to the FPP GGPP synthase family - - 2.5.1.1,2.5.1.10,2.5.1.29 ko:K13787 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00364,M00365 R01658,R02003,R02061 RC00279 ko00000,ko00001,ko00002,ko01000,ko01006 - - - polyprenyl_synt k59_187797_1 316407.85677082 7.93e-186 524.0 COG1167@1|root,COG1167@2|Bacteria,1MV6F@1224|Proteobacteria,1RMQ0@1236|Gammaproteobacteria,3XQJT@561|Escherichia 1236|Gammaproteobacteria K transaminase activity yjiR GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576 - - - - - - - - - - Aminotran_1_2,GntR k59_1543449_1 237368.SCABRO_03323 6.48e-57 199.0 COG3264@1|root,COG3264@2|Bacteria,2IY5W@203682|Planctomycetes 203682|Planctomycetes M COG3264 Small-conductance mechanosensitive channel - - - ko:K22051 - - - - ko00000,ko02000 1.A.23.1.2,1.A.23.1.3 - - MS_channel k59_809087_2 865861.AZSU01000003_gene2027 0.000641 45.4 COG3267@1|root,COG3267@2|Bacteria,1TRGM@1239|Firmicutes,24EPV@186801|Clostridia,36HUB@31979|Clostridiaceae 186801|Clostridia U AAA domain - - - - - - - - - - - - AAA_22 k59_1599524_1 1535287.JP74_13935 8.19e-43 155.0 COG0264@1|root,COG0264@2|Bacteria,1MUS2@1224|Proteobacteria,2TQM0@28211|Alphaproteobacteria,3N6FT@45401|Hyphomicrobiaceae 28211|Alphaproteobacteria J Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome tsf GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - ko:K02357 - - - - ko00000,ko03012,ko03029 - - - EF_TS k59_639239_1 1123073.KB899242_gene1149 2.03e-49 180.0 COG2902@1|root,COG2902@2|Bacteria,1MXNV@1224|Proteobacteria,1RQVZ@1236|Gammaproteobacteria,1X46R@135614|Xanthomonadales 135614|Xanthomonadales E glutamate dehydrogenase - - 1.4.1.2 ko:K15371 ko00220,ko00250,ko00430,ko00910,ko01100,map00220,map00250,map00430,map00910,map01100 - R00243 RC00006,RC02799 ko00000,ko00001,ko01000 - - - Bac_GDH,GDH_N k59_18005_1 1231185.BAMP01000029_gene434 5.81e-43 155.0 COG0566@1|root,COG0566@2|Bacteria,1QQ53@1224|Proteobacteria,2TVH5@28211|Alphaproteobacteria,43GPV@69277|Phyllobacteriaceae 28211|Alphaproteobacteria J tRNA rRNA methyltransferase SpoU spoU - - - - - - - - - - - SpoU_methylase k59_809091_1 1122201.AUAZ01000001_gene2431 4.34e-71 221.0 COG1540@1|root,COG1540@2|Bacteria,1MUYV@1224|Proteobacteria,1RSCZ@1236|Gammaproteobacteria,4659M@72275|Alteromonadaceae 1236|Gammaproteobacteria S Belongs to the UPF0271 (lamB) family lamB - - ko:K07160 - - - - ko00000 - - - LamB_YcsF k59_1599530_1 1121365.AQXB01000007_gene420 6.8e-50 170.0 COG1932@1|root,COG1932@2|Bacteria,2GKYK@201174|Actinobacteria,22K50@1653|Corynebacteriaceae 201174|Actinobacteria E Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine serC GO:0001505,GO:0003674,GO:0003824,GO:0004760,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005777,GO:0005886,GO:0006082,GO:0006520,GO:0006544,GO:0006545,GO:0006807,GO:0008150,GO:0008152,GO:0008453,GO:0008483,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016769,GO:0017144,GO:0019265,GO:0019752,GO:0040007,GO:0042133,GO:0042136,GO:0042579,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0065007,GO:0065008,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.6.1.52 ko:K00831 ko00260,ko00680,ko00750,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map00750,map01100,map01120,map01130,map01200,map01230 M00020,M00124 R04173,R05085 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_5 k59_809095_1 305900.GV64_14215 1.49e-13 69.7 COG2224@1|root,COG2224@2|Bacteria,1MWIF@1224|Proteobacteria,1RQAK@1236|Gammaproteobacteria,1XI4D@135619|Oceanospirillales 135619|Oceanospirillales C Phosphoenolpyruvate phosphomutase - - 4.1.3.1 ko:K01637 ko00630,ko01100,ko01110,ko01120,ko01200,map00630,map01100,map01110,map01120,map01200 M00012 R00479 RC00311,RC00313 ko00000,ko00001,ko00002,ko01000 - - - ICL k59_809095_2 377629.TERTU_0338 1.03e-50 175.0 COG1396@1|root,COG1396@2|Bacteria,1R3Z8@1224|Proteobacteria,1RRMV@1236|Gammaproteobacteria,2PPU3@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria K Protein of unknown function (DUF3612) - - - - - - - - - - - - DUF3612,HTH_19,HTH_3,Peptidase_M78 k59_639253_1 551275.KB899545_gene2986 3.81e-41 152.0 2C3QV@1|root,2Z7YP@2|Bacteria,1MXAM@1224|Proteobacteria,2U1FE@28211|Alphaproteobacteria,43WDC@69657|Hyphomonadaceae 28211|Alphaproteobacteria - - - - - - - - - - - - - - Alginate_exp k59_977215_1 1122137.AQXF01000001_gene2510 8.36e-100 311.0 COG3563@1|root,COG3563@2|Bacteria,1MW0T@1224|Proteobacteria,2TTAJ@28211|Alphaproteobacteria 28211|Alphaproteobacteria M Capsule polysaccharide - - - ko:K07266 - - - - ko00000 - - - Capsule_synth k59_1487406_1 436308.Nmar_1530 1.46e-62 196.0 COG0127@1|root,arCOG04184@2157|Archaea,41SKW@651137|Thaumarchaeota 651137|Thaumarchaeota F Belongs to the HAM1 NTPase family - - 3.6.1.66 ko:K02428 ko00230,map00230 - R00426,R00720,R01855,R02100,R02720,R03531 RC00002 ko00000,ko00001,ko01000 - - - Ham1p_like k59_1487406_2 1229909.NSED_08420 2.05e-35 126.0 COG0533@1|root,arCOG01185@2157|Archaea,41SJJ@651137|Thaumarchaeota 651137|Thaumarchaeota T Mn2 -dependent serine threonine protein kinase - - 2.7.11.1 ko:K08851 - - - - ko00000,ko01000,ko01001,ko03016 - - - Pkinase k59_1260372_1 1123503.KB908063_gene671 4.71e-26 110.0 COG1509@1|root,COG1509@2|Bacteria,1MUPJ@1224|Proteobacteria,2TT31@28211|Alphaproteobacteria,2KHHW@204458|Caulobacterales 204458|Caulobacterales C Lysine-2,3-aminomutase - - 5.4.3.2 ko:K01843 ko00310,map00310 - R00461 RC00303 ko00000,ko00001,ko01000 - - - Fer4_12,LAM_C,Radical_SAM k59_525543_1 1096930.L284_05155 4.15e-90 270.0 COG0351@1|root,COG0351@2|Bacteria,1MU9J@1224|Proteobacteria,2TUKR@28211|Alphaproteobacteria,2K24Q@204457|Sphingomonadales 204457|Sphingomonadales H Phosphomethylpyrimidine kinase thiD - 2.7.1.49,2.7.4.7 ko:K00941 ko00730,ko01100,map00730,map01100 M00127 R03471,R04509 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - Glyoxalase,Phos_pyr_kin k59_1374222_2 765912.Thimo_2336 5.56e-11 60.1 COG0607@1|root,COG0607@2|Bacteria,1MZ87@1224|Proteobacteria,1S98V@1236|Gammaproteobacteria,1WY49@135613|Chromatiales 135613|Chromatiales P PFAM Rhodanese-like - - - - - - - - - - - - Rhodanese k59_301032_2 543913.D521_1166 1.96e-16 78.6 COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,2VIR8@28216|Betaproteobacteria 28216|Betaproteobacteria C aldehyde oxidase and xanthine dehydrogenase, a b hammerhead - - 1.2.5.3 ko:K03520 - - R11168 RC02800 ko00000,ko01000 - - - Ald_Xan_dh_C,Ald_Xan_dh_C2 k59_752088_1 1316927.ATKI01000061_gene4045 9.54e-09 55.5 COG0243@1|root,COG0437@1|root,COG0243@2|Bacteria,COG0437@2|Bacteria,1MU1B@1224|Proteobacteria 1224|Proteobacteria C 4Fe-4S ferredoxin iron-sulfur binding domain protein actB - - ko:K00184 - - - - ko00000 5.A.3 - - Fer4_11,Fer4_7,Molybdop_Fe4S4,Molybdopterin,Molydop_binding k59_752088_2 926569.ANT_24790 2.14e-30 125.0 COG0243@1|root,COG0243@2|Bacteria,2G844@200795|Chloroflexi 200795|Chloroflexi C Molydopterin dinucleotide binding domain - - - - - - - - - - - - Molybdopterin,Molydop_binding k59_1487430_1 207954.MED92_00075 1.97e-54 173.0 COG0139@1|root,COG0139@2|Bacteria,1MW67@1224|Proteobacteria,1RMV4@1236|Gammaproteobacteria,1XK33@135619|Oceanospirillales 135619|Oceanospirillales E Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP hisI - 3.5.4.19 ko:K01496 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04037 RC01055 ko00000,ko00001,ko00002,ko01000 - - - His_biosynth,PRA-CH,PRA-PH k59_1375230_1 436308.Nmar_0099 2.45e-134 401.0 COG2511@1|root,arCOG01719@2157|Archaea,41S8Q@651137|Thaumarchaeota 651137|Thaumarchaeota J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate gatE - 6.3.5.7 ko:K03330 ko00970,ko01100,map00970,map01100 - R03905 RC00010 ko00000,ko00001,ko01000 - - - GAD,GatB_N,GatB_Yqey k59_1488374_1 1415778.JQMM01000001_gene1696 6.99e-100 322.0 COG0046@1|root,COG0047@1|root,COG0046@2|Bacteria,COG0047@2|Bacteria,1MYN4@1224|Proteobacteria,1RMRN@1236|Gammaproteobacteria,1J54G@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria F Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate purL GO:0000166,GO:0003674,GO:0003824,GO:0004642,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006163,GO:0006164,GO:0006188,GO:0006189,GO:0006520,GO:0006541,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009064,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016874,GO:0016879,GO:0016884,GO:0016887,GO:0017076,GO:0017111,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605 6.3.5.3 ko:K01952 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04463 RC00010,RC01160 ko00000,ko00001,ko00002,ko01000 - - iECH74115_1262.ECH74115_3792,iECO111_1330.ECO111_3283,iECSP_1301.ECSP_3501,iECs_1301.ECs3423,iG2583_1286.G2583_3088,iJN746.PP_1037,ic_1306.c3080 AIRS_C,GATase_5 k59_1148411_1 983545.Glaag_0846 1.42e-67 221.0 COG0773@1|root,COG0773@2|Bacteria,1MV68@1224|Proteobacteria,1RN88@1236|Gammaproteobacteria,465HW@72275|Alteromonadaceae 1236|Gammaproteobacteria M Belongs to the MurCDEF family murC GO:0000166,GO:0000270,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008763,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0017076,GO:0030203,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034645,GO:0035639,GO:0036094,GO:0042546,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0046872,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.3.2.8 ko:K01924 ko00471,ko00550,ko01100,map00471,map00550,map01100 - R03193 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - iECP_1309.ECP_0093 Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_1430849_1 316407.85674947 3.14e-166 484.0 2EWBD@1|root,33PQ4@2|Bacteria,1NS8J@1224|Proteobacteria,1SMS5@1236|Gammaproteobacteria,3XQG9@561|Escherichia 1236|Gammaproteobacteria S Protein of unknown function (DUF2773) ydbD - - - - - - - - - - - DUF2773 k59_358424_2 1144307.PMI04_02200 2.57e-59 191.0 COG1028@1|root,COG1028@2|Bacteria,1R9UK@1224|Proteobacteria,2U35Z@28211|Alphaproteobacteria,2KCN1@204457|Sphingomonadales 204457|Sphingomonadales IQ KR domain - - - - - - - - - - - - adh_short_C2 k59_1770167_2 1229909.NSED_00930 3.55e-43 141.0 COG1958@1|root,arCOG00998@2157|Archaea,41SU9@651137|Thaumarchaeota 651137|Thaumarchaeota K snRNP Sm proteins - - - ko:K04796 - - - - ko00000 - - - LSM k59_696682_1 215803.DB30_4656 5.82e-15 81.3 COG0515@1|root,COG0515@2|Bacteria,1Q389@1224|Proteobacteria,438Z3@68525|delta/epsilon subdivisions,2X44E@28221|Deltaproteobacteria,2YY87@29|Myxococcales 28221|Deltaproteobacteria KLT Protein kinase domain - - - - - - - - - - - - PEGA,Pkinase k59_696682_2 1123242.JH636434_gene3237 2.59e-06 48.5 COG0461@1|root,COG0461@2|Bacteria,2IZA7@203682|Planctomycetes 203682|Planctomycetes F Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) pyrE - 2.4.2.10 ko:K00762 ko00240,ko01100,map00240,map01100 M00051 R01870 RC00611 ko00000,ko00001,ko00002,ko01000 - - - Pribosyltran k59_1544514_1 745014.OMB55_00003830 6.17e-89 275.0 COG0404@1|root,COG0404@2|Bacteria,1MV96@1224|Proteobacteria,1RN2A@1236|Gammaproteobacteria 1236|Gammaproteobacteria E The glycine cleavage system catalyzes the degradation of glycine - - 2.1.2.10 ko:K00605 ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200 M00532 R01221,R02300,R04125 RC00022,RC00069,RC00183,RC02834 ko00000,ko00001,ko00002,ko01000 - - - DUF1989,GCV_T,GCV_T_C k59_1375250_1 316407.85676254 2.4e-108 323.0 2DB7H@1|root,2Z7MA@2|Bacteria,1MVRX@1224|Proteobacteria,1RR2C@1236|Gammaproteobacteria,3XPD5@561|Escherichia 1236|Gammaproteobacteria S Probably involved in the polymerization of enterobacterial common antigen (ECA) trisaccharide repeat units wzyE GO:0000271,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0005976,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009246,GO:0009987,GO:0016020,GO:0016051,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044464,GO:0046378,GO:0071704,GO:0071944,GO:1901135,GO:1901137,GO:1901576 - ko:K02853 - - - - ko00000,ko01000,ko01003 - - - WzyE k59_188708_1 627192.SLG_07230 2.12e-42 149.0 COG0625@1|root,COG0625@2|Bacteria,1R6UY@1224|Proteobacteria,2U1WS@28211|Alphaproteobacteria 28211|Alphaproteobacteria O Glutathione S-transferase, C-terminal domain - - 2.5.1.18 ko:K00799 ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418 - R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905 RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944 ko00000,ko00001,ko01000,ko02000 1.A.12.2.2,1.A.12.3.2 - - GST_C,GST_C_2,GST_N_3 k59_76351_2 1280944.HY17_13885 8.15e-73 221.0 COG3175@1|root,COG3175@2|Bacteria,1RDTU@1224|Proteobacteria,2U6ZT@28211|Alphaproteobacteria,43XKP@69657|Hyphomonadaceae 28211|Alphaproteobacteria O Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I ctaG - - ko:K02258 ko00190,ko01100,ko04714,map00190,map01100,map04714 M00154 - - ko00000,ko00001,ko00002,ko03029 3.D.4.8 - - CtaG_Cox11 k59_583602_1 498211.CJA_1389 2.69e-66 209.0 COG1702@1|root,COG1702@2|Bacteria,1PNF2@1224|Proteobacteria,1RNZ7@1236|Gammaproteobacteria,1FG1H@10|Cellvibrio 1236|Gammaproteobacteria T PhoH-like protein phoH GO:0000166,GO:0003674,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008144,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - ko:K06217 - - - - ko00000 - - - PhoH k59_583605_1 1335757.SPICUR_08955 3.64e-47 172.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1WX5S@135613|Chromatiales 135613|Chromatiales V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K18989 - M00720 - - ko00000,ko00002,ko02000 2.A.6.2.30 - - ACR_tran k59_1430881_1 1197477.IA57_02565 1.56e-58 192.0 28I9R@1|root,2Z8CE@2|Bacteria,4NE54@976|Bacteroidetes,1HWWD@117743|Flavobacteriia 976|Bacteroidetes S PFAM Lipid A 3-O-deacylase (PagL) - - - - - - - - - - - - PagL k59_867160_1 1454004.AW11_01943 2.16e-87 281.0 COG0653@1|root,COG0653@2|Bacteria,1MUJZ@1224|Proteobacteria,2VHDH@28216|Betaproteobacteria,1KPQR@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane secA - - ko:K03070 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4 - - SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW k59_696708_1 316407.85675387 8.03e-48 162.0 COG0006@1|root,COG0006@2|Bacteria,1MUZS@1224|Proteobacteria,1RYKI@1236|Gammaproteobacteria,3XNJ0@561|Escherichia 1236|Gammaproteobacteria E Hydrolyzes the N-terminal methionine when the next amino acid is alanine, proline or serine. The substrate preference for methionyl aminopeptidase activity is Pro Ala Ser. Also able to hydrolyze the Xaa-Pro peptide bond when the first amino acid is alanine, asparagine or methionine ypdF GO:0003674,GO:0003824,GO:0004177,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0016787,GO:0019538,GO:0043170,GO:0044238,GO:0070011,GO:0071704,GO:0140096,GO:1901564 3.4.11.9 ko:K01262,ko:K08326 - - - - ko00000,ko01000,ko01002 - - - Creatinase_N,Peptidase_M24 k59_696708_2 316407.1799797 2.67e-69 220.0 COG1299@1|root,COG1299@2|Bacteria,1R4ND@1224|Proteobacteria,1RZX0@1236|Gammaproteobacteria,3XPEA@561|Escherichia 1236|Gammaproteobacteria G The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane fryC GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0008643,GO:0009401,GO:0015144,GO:0016020,GO:0016740,GO:0016772,GO:0016773,GO:0022804,GO:0022857,GO:0034219,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0090563 - ko:K11203 - M00306 - - ko00000,ko00002,ko02000 4.A.2.1 - - PTS_EIIC k59_1770193_1 521719.ATXQ01000006_gene1357 2.76e-109 335.0 COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,1RQUR@1236|Gammaproteobacteria,1YEIQ@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria F Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen nrdZ - 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - Intein_splicing,LAGLIDADG_3,Ribonuc_red_lgC,Ribonuc_red_lgN k59_76371_1 338969.Rfer_2739 3.4e-63 210.0 COG3005@1|root,COG3005@2|Bacteria 2|Bacteria C denitrification pathway - - - - - - - - - - - - Cytochrom_c3_2,Cytochrome_C554,Ni_hydr_CYTB,Paired_CXXCH_1 k59_470728_1 1205680.CAKO01000037_gene1298 7.1e-68 230.0 COG0439@1|root,COG1038@1|root,COG4799@1|root,COG0439@2|Bacteria,COG1038@2|Bacteria,COG4799@2|Bacteria,1MU4H@1224|Proteobacteria,2TWYZ@28211|Alphaproteobacteria,2JZ2C@204441|Rhodospirillales 204441|Rhodospirillales I Biotin carboxylase C-terminal domain - - - - - - - - - - - - Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2,Carboxyl_trans k59_1375271_1 1121921.KB898710_gene500 4.38e-80 243.0 COG0625@1|root,COG0625@2|Bacteria,1MXJD@1224|Proteobacteria,1RP12@1236|Gammaproteobacteria,2PMS3@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria O Glutathione S-transferase, C-terminal domain sspA GO:0001000,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0006950,GO:0008150,GO:0009605,GO:0009889,GO:0009891,GO:0009893,GO:0009991,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0019899,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031667,GO:0042594,GO:0043175,GO:0044424,GO:0044444,GO:0044464,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0070063,GO:0080090,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141 - ko:K03599 - - - - ko00000,ko02000,ko03021 1.A.12.3.1 - - GST_C,GST_N,GST_N_3 k59_867172_2 867900.Celly_1136 3.82e-81 246.0 COG4221@1|root,COG4221@2|Bacteria,4NE1R@976|Bacteroidetes,1HY5P@117743|Flavobacteriia,1F8VZ@104264|Cellulophaga 976|Bacteroidetes S Belongs to the short-chain dehydrogenases reductases (SDR) family ydfG - - - - - - - - - - - adh_short k59_922836_1 398767.Glov_2017 1.84e-103 312.0 COG0343@1|root,COG0343@2|Bacteria,1MUCA@1224|Proteobacteria,42M5Y@68525|delta/epsilon subdivisions,2WIMT@28221|Deltaproteobacteria,43SUZ@69541|Desulfuromonadales 28221|Deltaproteobacteria J Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) tgt-1 - 2.4.2.29 ko:K00773 - - R03789,R10209 RC00063 ko00000,ko01000,ko03016 - - - TGT k59_922836_2 83406.HDN1F_00350 6.36e-144 422.0 COG1680@1|root,COG1680@2|Bacteria,1R5MK@1224|Proteobacteria,1S015@1236|Gammaproteobacteria,1JBWQ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria V Beta-lactamase - - - - - - - - - - - - Beta-lactamase k59_244613_1 1229909.NSED_01560 3.83e-215 610.0 COG0449@1|root,arCOG00057@2157|Archaea,41SFG@651137|Thaumarchaeota 651137|Thaumarchaeota M TIGRFAM glucosamine--fructose-6-phosphate aminotransferase (isomerizing) - - 2.6.1.16 ko:K00820 ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931 - R00768 RC00010,RC00163,RC02752 ko00000,ko00001,ko01000,ko01002 - - - GATase_6,SIS k59_244613_2 1229909.NSED_01555 1.18e-197 554.0 COG2038@1|root,arCOG04272@2157|Archaea,41SD3@651137|Thaumarchaeota 651137|Thaumarchaeota H Belongs to the UPF0284 family - - - - - - - - - - - - DBI_PRT k59_244613_3 436308.Nmar_0321 1.9e-111 323.0 arCOG00517@1|root,arCOG00517@2157|Archaea,41SHJ@651137|Thaumarchaeota 651137|Thaumarchaeota S Metallo-beta-lactamase superfamily - - - - - - - - - - - - Lactamase_B k59_244613_4 1229909.NSED_01545 7.99e-99 291.0 COG0063@1|root,arCOG00018@2157|Archaea,41SHM@651137|Thaumarchaeota 651137|Thaumarchaeota G Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S- specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX nnrE - 5.1.99.6 ko:K17759 - - - - ko00000,ko01000 - - - YjeF_N k59_922845_1 436308.Nmar_0115 3.33e-110 332.0 COG1964@1|root,arCOG00933@2157|Archaea,41SAY@651137|Thaumarchaeota 651137|Thaumarchaeota S Radical SAM - - - ko:K06937 - - - - ko00000,ko01000 - - - Fer4_12,Radical_SAM k59_1205253_1 1429851.X548_14705 2.99e-102 318.0 COG1629@1|root,COG4771@2|Bacteria,1MW7D@1224|Proteobacteria,1RNET@1236|Gammaproteobacteria,1X3EK@135614|Xanthomonadales 135614|Xanthomonadales P receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_302111_1 1229909.NSED_00670 5.59e-20 86.3 COG0077@1|root,arCOG00255@2157|Archaea,41SA8@651137|Thaumarchaeota 651137|Thaumarchaeota E Prephenate dehydratase - - 4.2.1.51 ko:K04518 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00024 R00691,R01373 RC00360 ko00000,ko00001,ko00002,ko01000 - - - ACT,PDT k59_1267437_1 945713.IALB_2868 5.03e-99 302.0 COG2986@1|root,COG2986@2|Bacteria 2|Bacteria E ammonia-lyase activity hutH - 4.3.1.3 ko:K01745 ko00340,ko01100,map00340,map01100 M00045 R01168 RC00361 ko00000,ko00001,ko00002,ko01000 - - - Lyase_aromatic k59_366722_1 436308.Nmar_0015 1.12e-56 179.0 COG0239@1|root,arCOG04701@2157|Archaea,41T4U@651137|Thaumarchaeota 651137|Thaumarchaeota U Important for reducing fluoride concentration in the cell, thus reducing its toxicity crcB - - ko:K06199 - - - - ko00000,ko02000 1.A.43.1,1.A.43.2,1.A.43.3 - - CRCB k59_366722_2 419665.Maeo_0631 6.3e-09 57.4 COG0517@1|root,arCOG00606@2157|Archaea,2XX11@28890|Euryarchaeota,23QUR@183939|Methanococci 183939|Methanococci S PFAM CBS domain containing protein - - - - - - - - - - - - CBS k59_139788_2 436308.Nmar_0587 1.61e-27 102.0 COG0347@1|root,arCOG02305@2157|Archaea 2157|Archaea K Belongs to the P(II) protein family - - - ko:K04751 ko02020,map02020 - - - ko00000,ko00001 - - - DUF2226,P-II k59_531921_2 1121324.CLIT_10c04310 1.01e-22 102.0 COG5001@1|root,COG5001@2|Bacteria,1TP8V@1239|Firmicutes,247PX@186801|Clostridia 186801|Clostridia T Diguanylate cyclase - - - - - - - - - - - - EAL,GGDEF,PAS,PAS_3,PAS_9 k59_875035_1 477641.MODMU_2777 8.14e-24 100.0 COG3342@1|root,COG3342@2|Bacteria,2HWBG@201174|Actinobacteria 201174|Actinobacteria S Family of unknown function (DUF1028) - - - - - - - - - - - - DUF1028,PG_binding_2 k59_420871_1 1122137.AQXF01000001_gene3100 3.42e-187 547.0 COG1629@1|root,COG4771@2|Bacteria,1MU9K@1224|Proteobacteria,2TS65@28211|Alphaproteobacteria 28211|Alphaproteobacteria P COG1629 Outer membrane receptor proteins, mostly Fe transport - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_1383099_2 1234593.ANBY01000030_gene1185 7.82e-44 152.0 COG0036@1|root,COG0036@2|Bacteria,1TQK8@1239|Firmicutes,4H9RW@91061|Bacilli,4GY9V@90964|Staphylococcaceae 91061|Bacilli G Belongs to the ribulose-phosphate 3-epimerase family rpe GO:0003674,GO:0003824,GO:0004750,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009052,GO:0009056,GO:0009117,GO:0009987,GO:0016052,GO:0016853,GO:0016854,GO:0016857,GO:0019321,GO:0019323,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046483,GO:0046496,GO:0046872,GO:0051156,GO:0051186,GO:0055086,GO:0071704,GO:0072524,GO:1901135,GO:1901360,GO:1901564,GO:1901575 5.1.3.1 ko:K01783 ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007 R01529 RC00540 ko00000,ko00001,ko00002,ko01000 - - - Ribul_P_3_epim k59_1552998_1 1535422.ND16A_1363 1.07e-85 271.0 28HMZ@1|root,2Z7WD@2|Bacteria,1MU3Q@1224|Proteobacteria,1RRUM@1236|Gammaproteobacteria,2Q6Y5@267889|Colwelliaceae 1236|Gammaproteobacteria S Protein of unknown function (DUF3604) - - - - - - - - - - - - DUF3604 k59_928556_1 1540221.JQNI01000002_gene2003 4.48e-80 266.0 COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,1WIA7@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus E PFAM Conserved region in glutamate synthase - - 1.4.1.13,1.4.1.14,1.4.7.1 ko:K00265,ko:K00284 ko00250,ko00630,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00630,map00910,map01100,map01110,map01120,map01130,map01230 - R00021,R00093,R00114,R00248,R10086 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - GATase_2,GXGXG,Glu_syn_central,Glu_synthase k59_84278_1 1245471.PCA10_28000 1.12e-88 275.0 COG2159@1|root,COG2159@2|Bacteria,1RK9M@1224|Proteobacteria,1TBK9@1236|Gammaproteobacteria,1YIPE@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria S Amidohydrolase - - - - - - - - - - - - Amidohydro_2 k59_646078_1 59196.RICGR_1308 6.01e-63 213.0 COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,1RPCB@1236|Gammaproteobacteria,1JCUY@118969|Legionellales 118969|Legionellales O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner lon - 3.4.21.53 ko:K01338 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - AAA,LON_substr_bdg,Lon_C k59_646078_2 314278.NB231_16053 1.65e-30 121.0 COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,1RPCB@1236|Gammaproteobacteria,1WWYF@135613|Chromatiales 135613|Chromatiales O ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner lon - 3.4.21.53 ko:K01338 ko04112,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - AAA,LON_substr_bdg,Lon_C k59_309872_2 1122137.AQXF01000006_gene794 6.75e-93 287.0 COG1538@1|root,COG1538@2|Bacteria,1MWCJ@1224|Proteobacteria,2TR3S@28211|Alphaproteobacteria 28211|Alphaproteobacteria MU type I secretion outer membrane protein, TolC - - - ko:K12340 ko01501,ko01503,ko02020,ko03070,ko04626,ko05133,map01501,map01503,map02020,map03070,map04626,map05133 M00325,M00326,M00339,M00571,M00575,M00646,M00647,M00696,M00697,M00709,M00720,M00821 - - ko00000,ko00001,ko00002,ko01504,ko02000,ko02044 1.B.17,2.A.6.2 - - OEP k59_1213052_1 572477.Alvin_0015 6.51e-81 268.0 COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,1SP6I@1236|Gammaproteobacteria,1WX2G@135613|Chromatiales 135613|Chromatiales P Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K15726 - - - - ko00000,ko02000 2.A.6.1.2 - - ACR_tran k59_195421_1 926554.KI912640_gene1366 6.62e-25 105.0 COG1960@1|root,COG1960@2|Bacteria,1WMGQ@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus I Acyl-CoA dehydrogenase, C-terminal domain - - - - - - - - - - - - Acyl-CoA_dh_2,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_1384085_1 1155718.KB891962_gene366 7.25e-53 180.0 COG0477@1|root,COG2814@2|Bacteria,2GPRH@201174|Actinobacteria 201174|Actinobacteria EGP Major Facilitator - - - - - - - - - - - - MFS_1 k59_1099180_1 1379701.JPJC01000019_gene3395 1.62e-106 320.0 COG3666@1|root,COG3666@2|Bacteria,1N3QR@1224|Proteobacteria,2TRXG@28211|Alphaproteobacteria,2K252@204457|Sphingomonadales 204457|Sphingomonadales L Transposase DDE domain - - - - - - - - - - - - DDE_Tnp_1,DDE_Tnp_1_6,DUF772 k59_1609940_1 1254432.SCE1572_03070 6.07e-76 253.0 COG0085@1|root,COG0085@2|Bacteria,1MUC4@1224|Proteobacteria,43DMZ@68525|delta/epsilon subdivisions,2WIW5@28221|Deltaproteobacteria,2YUEA@29|Myxococcales 28221|Deltaproteobacteria K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoB GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234 2.7.7.6 ko:K03043 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7 k59_1609940_2 1304885.AUEY01000001_gene3251 9.68e-09 55.8 COG0086@1|root,COG0086@2|Bacteria,1MU3M@1224|Proteobacteria,42NAW@68525|delta/epsilon subdivisions,2WISU@28221|Deltaproteobacteria,2MIYJ@213118|Desulfobacterales 28221|Deltaproteobacteria K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoC - 2.7.7.6 ko:K03046 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5 k59_1609941_1 1229909.NSED_01625 3.25e-113 331.0 COG0039@1|root,arCOG00246@2157|Archaea,41S7Z@651137|Thaumarchaeota 651137|Thaumarchaeota C Belongs to the LDH MDH superfamily - - 1.1.1.37 ko:K00024 ko00020,ko00270,ko00620,ko00630,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00270,map00620,map00630,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740 R00342,R07136 RC00031 ko00000,ko00001,ko00002,ko01000 - - - Ldh_1_C,Ldh_1_N k59_140707_1 525379.HMPREF0819_0412 6.62e-41 145.0 COG0348@1|root,COG0348@2|Bacteria,1TRZZ@1239|Firmicutes 1239|Firmicutes C 4Fe-4S binding domain protein - - - - - - - - - - - - Fer4,Fer4_5,Fer4_9 k59_367788_1 1219035.NT2_07_00320 8.01e-17 79.3 COG3173@1|root,COG3173@2|Bacteria,1MWAK@1224|Proteobacteria,2TT2N@28211|Alphaproteobacteria,2K142@204457|Sphingomonadales 204457|Sphingomonadales S Aminoglycoside phosphotransferase - - - - - - - - - - - - APH k59_367788_2 247633.GP2143_02389 5.48e-22 100.0 COG2271@1|root,COG2271@2|Bacteria,1P3P1@1224|Proteobacteria,1SJJ1@1236|Gammaproteobacteria 1236|Gammaproteobacteria G COG0477 Permeases of the major facilitator superfamily - - - - - - - - - - - - MFS_1 k59_592361_1 1442598.JABW01000034_gene1661 3.01e-52 181.0 COG3039@1|root,COG3039@2|Bacteria,1MVTU@1224|Proteobacteria,42Q03@68525|delta/epsilon subdivisions,2YRPJ@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria L Transposase domain (DUF772) - - - - - - - - - - - - DDE_Tnp_1,DUF772 k59_1099195_2 1187851.A33M_1936 2.04e-68 211.0 COG3293@1|root,COG3293@2|Bacteria,1RFRK@1224|Proteobacteria,2U8TH@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Putative transposase of IS4/5 family (DUF4096) - - - - - - - - - - - - DUF4096 k59_592364_1 555793.WSK_1274 6.67e-43 149.0 COG1695@1|root,COG1695@2|Bacteria,1RHSE@1224|Proteobacteria,2U1HF@28211|Alphaproteobacteria,2K4SR@204457|Sphingomonadales 204457|Sphingomonadales K transcriptional - - - - - - - - - - - - PadR k59_705677_1 1232437.KL661964_gene3344 3.13e-22 99.0 COG1639@1|root,COG1639@2|Bacteria,1NJC4@1224|Proteobacteria,42M0G@68525|delta/epsilon subdivisions,2WJTM@28221|Deltaproteobacteria,2MI3Q@213118|Desulfobacterales 28221|Deltaproteobacteria T HDOD domain - - - - - - - - - - - - HDOD k59_367796_1 1144342.PMI40_02455 7.17e-46 167.0 COG1009@1|root,COG1009@2|Bacteria,1MW2M@1224|Proteobacteria,2VJ2J@28216|Betaproteobacteria,472FQ@75682|Oxalobacteraceae 28216|Betaproteobacteria CP NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus nuoL - 1.6.5.3 ko:K00341 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Proton_antipo_C,Proton_antipo_M,Proton_antipo_N k59_646819_2 887898.HMPREF0551_0794 3.37e-124 357.0 COG0479@1|root,COG0479@2|Bacteria,1MVHS@1224|Proteobacteria,2VIKC@28216|Betaproteobacteria,1K01D@119060|Burkholderiaceae 28216|Betaproteobacteria C Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family sdhB - 1.3.5.1,1.3.5.4 ko:K00240 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00149,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 - - - Fer2_3,Fer4_17,Fer4_8 k59_140722_1 1453501.JELR01000001_gene3250 2.77e-36 137.0 COG4784@1|root,COG4784@2|Bacteria,1QTT7@1224|Proteobacteria,1RSQ1@1236|Gammaproteobacteria,46CNY@72275|Alteromonadaceae 1236|Gammaproteobacteria S Peptidase family M48 - - - - - - - - - - - - Peptidase_M48 k59_592371_1 383372.Rcas_1323 2.49e-29 108.0 COG0377@1|root,COG0377@2|Bacteria,2G6GB@200795|Chloroflexi,375GU@32061|Chloroflexia 32061|Chloroflexia C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoB1 - 1.6.5.3 ko:K00331 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q6 k59_592371_2 887898.HMPREF0551_0475 1.93e-26 102.0 COG0838@1|root,COG0838@2|Bacteria,1RGUT@1224|Proteobacteria,2VSI3@28216|Betaproteobacteria,1K7MQ@119060|Burkholderiaceae 28216|Betaproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoA - 1.6.5.3 ko:K00330 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q4 k59_646823_1 765911.Thivi_3567 2.12e-70 233.0 COG3808@1|root,COG3808@2|Bacteria,1MUQ3@1224|Proteobacteria,1RN4K@1236|Gammaproteobacteria,1WXW2@135613|Chromatiales 135613|Chromatiales C Sodium pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for Na( ) movement across the membrane - - 3.6.1.1 ko:K15987 ko00190,map00190 - - - ko00000,ko00001,ko01000 3.A.10.1 - - H_PPase k59_929279_1 316407.1651504 1.02e-58 194.0 COG0591@1|root,COG0591@2|Bacteria,1MUBI@1224|Proteobacteria,1RMXU@1236|Gammaproteobacteria,3XNW6@561|Escherichia 1236|Gammaproteobacteria P Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family putP GO:0003333,GO:0003674,GO:0005215,GO:0005283,GO:0005298,GO:0005342,GO:0005343,GO:0005416,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006814,GO:0006820,GO:0006865,GO:0006869,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0010876,GO:0015075,GO:0015077,GO:0015081,GO:0015171,GO:0015291,GO:0015293,GO:0015294,GO:0015318,GO:0015370,GO:0015672,GO:0015711,GO:0015718,GO:0015804,GO:0015824,GO:0015849,GO:0015908,GO:0015912,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0022890,GO:0030001,GO:0031224,GO:0031226,GO:0033036,GO:0034220,GO:0035725,GO:0044425,GO:0044459,GO:0044464,GO:0046873,GO:0046942,GO:0046943,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0098655,GO:0098656,GO:0098660,GO:0098662,GO:1903825,GO:1905039 - ko:K11928 - - - - ko00000,ko02000 2.A.21.2 - iSbBS512_1146.SbBS512_E2302 SSF k59_1214001_1 489825.LYNGBM3L_17170 1.73e-25 110.0 COG5555@1|root,COG5555@2|Bacteria,1GR73@1117|Cyanobacteria 2|Bacteria N Integrin alpha (beta-propellor repeats). - - - - - - - - - - - - FG-GAP k59_984985_1 983917.RGE_26780 3.13e-60 198.0 COG4948@1|root,COG4948@2|Bacteria,1Q9Q7@1224|Proteobacteria,2W9AP@28216|Betaproteobacteria,1KP04@119065|unclassified Burkholderiales 28216|Betaproteobacteria M Mandelate racemase / muconate lactonizing enzyme, C-terminal domain - - 5.1.1.20 ko:K19802 - - R10938 RC03309 ko00000,ko01000 - - - MR_MLE_C,MR_MLE_N k59_310909_1 1121015.N789_11380 2.73e-64 214.0 COG0768@1|root,COG0768@2|Bacteria,1MUNY@1224|Proteobacteria,1RNGW@1236|Gammaproteobacteria,1X3X2@135614|Xanthomonadales 135614|Xanthomonadales M Catalyzes cross-linking of the peptidoglycan cell wall at the division septum ftsI - 3.4.16.4 ko:K03587 ko00550,ko01501,map00550,map01501 - - - ko00000,ko00001,ko01000,ko01011,ko03036 - - - PBP_dimer,Transpeptidase k59_1325054_1 1190606.AJYG01000088_gene3565 2.92e-12 72.4 COG3209@1|root,COG3209@2|Bacteria,1MVV1@1224|Proteobacteria,1RMPT@1236|Gammaproteobacteria,1XV5E@135623|Vibrionales 135623|Vibrionales M COG3209 Rhs family protein - - - - - - - - - - - - RHS_repeat,SpvB,TcdB_toxin_midN,VCBS k59_984986_1 199310.c4888 1.02e-117 357.0 COG1198@1|root,COG1198@2|Bacteria,1MUUZ@1224|Proteobacteria,1RPZ7@1236|Gammaproteobacteria,3XNVC@561|Escherichia 1236|Gammaproteobacteria L Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA priA GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006268,GO:0006270,GO:0006276,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009628,GO:0009987,GO:0010212,GO:0010332,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0033554,GO:0034641,GO:0034645,GO:0042221,GO:0042623,GO:0043138,GO:0043140,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0046483,GO:0046677,GO:0050896,GO:0051276,GO:0051716,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360,GO:1901576 - ko:K04066 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,Helicase_C,ResIII k59_1268240_1 1229909.NSED_01015 8.32e-22 90.1 COG1573@1|root,arCOG00905@2157|Archaea 2157|Archaea L Uracil-DNA glycosylase - GO:0003674,GO:0003824,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097506,GO:0140097,GO:1901360 3.2.2.27 ko:K21929 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - UDG k59_876125_1 1144305.PMI02_02113 1.97e-101 311.0 COG1154@1|root,COG1154@2|Bacteria,1MUSJ@1224|Proteobacteria,2TRDD@28211|Alphaproteobacteria,2K0XY@204457|Sphingomonadales 204457|Sphingomonadales H Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) dxs - 2.2.1.7 ko:K01662 ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130 M00096 R05636 RC00032 ko00000,ko00001,ko00002,ko01000 - - - DXP_synthase_N,Transket_pyr,Transketolase_C k59_759490_1 979556.MTES_1486 5.47e-09 59.7 COG1716@1|root,COG1716@2|Bacteria,2GNU2@201174|Actinobacteria,4FKVU@85023|Microbacteriaceae 201174|Actinobacteria T Protein of unknown function (DUF2662) fhaA GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944,GO:0097159,GO:1901363 - - - - - - - - - - DUF3662,FHA,Yop-YscD_cpl k59_759490_2 35754.JNYJ01000013_gene1114 1.1e-26 110.0 COG1716@1|root,COG1716@2|Bacteria,2GNU2@201174|Actinobacteria,4DB9K@85008|Micromonosporales 201174|Actinobacteria T FHA domain fhaA GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944,GO:0097159,GO:1901363 - - - - - - - - - - DUF3662,FHA,Yop-YscD_cpl k59_1722745_1 398525.KB900701_gene6702 1.16e-122 372.0 COG3119@1|root,COG3119@2|Bacteria,1MV92@1224|Proteobacteria,2TTXG@28211|Alphaproteobacteria,3JVJZ@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria P Sulfatase - - 3.1.6.1 ko:K01130 ko00140,ko00600,map00140,map00600 - R03980,R04856 RC00128,RC00231 ko00000,ko00001,ko01000 - - - Sulfatase k59_1045859_1 1500890.JQNL01000001_gene1471 2.49e-67 225.0 COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,1RNJI@1236|Gammaproteobacteria,1X3W3@135614|Xanthomonadales 135614|Xanthomonadales L Unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present uvrD - 3.6.4.12 ko:K03657 ko03420,ko03430,map03420,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - UvrD-helicase,UvrD_C k59_929288_1 1297865.APJD01000006_gene4496 7e-146 427.0 COG2072@1|root,COG2072@2|Bacteria,1MY00@1224|Proteobacteria,2U4J4@28211|Alphaproteobacteria,3JWBN@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria P Flavin-binding monooxygenase-like - - - - - - - - - - - - FMO-like k59_929288_2 1121403.AUCV01000001_gene771 1.76e-12 73.2 COG0681@1|root,COG0681@2|Bacteria,1MXUF@1224|Proteobacteria,42NJE@68525|delta/epsilon subdivisions,2WKMA@28221|Deltaproteobacteria,2MIAI@213118|Desulfobacterales 28221|Deltaproteobacteria U Belongs to the peptidase S26 family lepB_2 - 3.4.21.89 ko:K03100 ko02024,ko03060,map02024,map03060 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_S24,Peptidase_S26 k59_1554208_1 702113.PP1Y_AT29797 1.4e-100 305.0 COG0166@1|root,COG0166@2|Bacteria,1MUFP@1224|Proteobacteria,2TQKP@28211|Alphaproteobacteria,2K0KU@204457|Sphingomonadales 204457|Sphingomonadales G Belongs to the GPI family pgi GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 5.3.1.9 ko:K01810 ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200 M00001,M00004,M00114 R02739,R02740,R03321 RC00376,RC00563 ko00000,ko00001,ko00002,ko01000,ko04147 - - - PGI k59_253111_1 1168065.DOK_15159 6.32e-39 148.0 COG0243@1|root,COG0243@2|Bacteria,1NS3T@1224|Proteobacteria,1S096@1236|Gammaproteobacteria,1J7ZV@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - - - - - - - - - - - Molybdopterin,Molydop_binding k59_1325067_1 876044.IMCC3088_1539 5.47e-106 317.0 COG0536@1|root,COG0536@2|Bacteria,1MUGZ@1224|Proteobacteria,1RMFQ@1236|Gammaproteobacteria,1J4R8@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control obg GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006996,GO:0007059,GO:0008150,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019003,GO:0022607,GO:0022611,GO:0022613,GO:0022618,GO:0032502,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034622,GO:0035639,GO:0036094,GO:0042254,GO:0042255,GO:0043021,GO:0043023,GO:0043167,GO:0043168,GO:0043933,GO:0044085,GO:0044087,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0065003,GO:0065007,GO:0070925,GO:0071826,GO:0071840,GO:0090069,GO:0090071,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - ko:K03979 - - - - ko00000,ko01000,ko03009 - - - GTP1_OBG,MMR_HSR1 k59_421637_1 1415778.JQMM01000001_gene517 2.32e-124 369.0 COG4783@1|root,COG4783@2|Bacteria,1QUMJ@1224|Proteobacteria,1T2RP@1236|Gammaproteobacteria,1JC22@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Peptidase family M48 - - - - - - - - - - - - Peptidase_M48,TPR_16,TPR_2,TPR_8 k59_705722_1 216432.CA2559_07165 1.91e-116 351.0 COG0443@1|root,COG0443@2|Bacteria,4NERF@976|Bacteroidetes,1HWQ0@117743|Flavobacteriia 976|Bacteroidetes O Heat shock 70 kDa protein dnaK - - ko:K04043 ko03018,ko04212,ko05152,map03018,map04212,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 1.A.33.1 - - HSP70 k59_1722763_1 105559.Nwat_2900 7.02e-37 129.0 COG0360@1|root,COG0360@2|Bacteria,1RH82@1224|Proteobacteria,1S5VU@1236|Gammaproteobacteria,1WYA2@135613|Chromatiales 135613|Chromatiales J Binds together with S18 to 16S ribosomal RNA rpsF - - ko:K02990 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011,ko03029 - - - Ribosomal_S6 k59_1722763_2 1165096.ARWF01000001_gene382 2.12e-08 51.6 COG0238@1|root,COG0238@2|Bacteria,1MZ8U@1224|Proteobacteria,2VTWT@28216|Betaproteobacteria,2KN2Q@206350|Nitrosomonadales 206350|Nitrosomonadales J Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit rpsR - - ko:K02963 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S18 k59_1610012_1 644282.Deba_0617 3.56e-09 63.2 COG0451@1|root,COG0451@2|Bacteria,1MX2J@1224|Proteobacteria,42TZR@68525|delta/epsilon subdivisions,2WQ4T@28221|Deltaproteobacteria 28221|Deltaproteobacteria M NmrA-like family - - - - - - - - - - - - Epimerase k59_28323_1 1122137.AQXF01000003_gene2487 3.58e-80 249.0 COG0438@1|root,COG0438@2|Bacteria,1PDR7@1224|Proteobacteria,2U1R4@28211|Alphaproteobacteria 28211|Alphaproteobacteria M glycosyl transferase - - - - - - - - - - - - Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1 k59_28323_2 1122137.AQXF01000003_gene2486 6.69e-32 120.0 COG0381@1|root,COG0381@2|Bacteria,1MWZN@1224|Proteobacteria,2TTGZ@28211|Alphaproteobacteria 28211|Alphaproteobacteria M Belongs to the UDP-N-acetylglucosamine 2-epimerase family wecB - 5.1.3.14 ko:K01791 ko00520,ko01100,ko05111,map00520,map01100,map05111 M00362 R00420 RC00290 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Epimerase_2 k59_705729_1 1492737.FEM08_29100 1.08e-99 301.0 COG3328@1|root,COG3328@2|Bacteria,4NFQS@976|Bacteroidetes,1HZYN@117743|Flavobacteriia,2NTPJ@237|Flavobacterium 976|Bacteroidetes L Transposase, Mutator family - - - - - - - - - - - - Transposase_mut k59_1437530_1 314282.PCNPT3_03760 8.93e-09 56.2 COG0322@1|root,COG0322@2|Bacteria,1MV38@1224|Proteobacteria,1RNGV@1236|Gammaproteobacteria,2QHB2@267894|Psychromonadaceae 1236|Gammaproteobacteria L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision uvrC GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009314,GO:0009380,GO:0009381,GO:0009628,GO:0009987,GO:0016787,GO:0016788,GO:0032991,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1902494,GO:1905347,GO:1905348,GO:1990391 - ko:K03703 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - GIY-YIG,HHH,HHH_2,HHH_5,UVR,UvrC_HhH_N k59_1437530_2 644801.Psest_2258 2.98e-50 167.0 COG0558@1|root,COG0558@2|Bacteria,1RCZ7@1224|Proteobacteria,1S465@1236|Gammaproteobacteria,1Z17H@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria I Belongs to the CDP-alcohol phosphatidyltransferase class-I family pgsA GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006629,GO:0006644,GO:0006650,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008444,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016020,GO:0016021,GO:0016740,GO:0016772,GO:0016780,GO:0017169,GO:0019637,GO:0031224,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044425,GO:0044464,GO:0045017,GO:0046474,GO:0046486,GO:0071704,GO:0071944,GO:0090407,GO:1901576 2.7.8.41,2.7.8.5 ko:K00995,ko:K08744 ko00564,ko01100,map00564,map01100 - R01801,R02030 RC00002,RC00017,RC02795 ko00000,ko00001,ko01000 - - iAF1260.b1912,iAPECO1_1312.APECO1_954,iB21_1397.B21_01866,iBWG_1329.BWG_1721,iE2348C_1286.E2348C_2030,iEC042_1314.EC042_2073,iEC55989_1330.EC55989_2132,iECABU_c1320.ECABU_c21710,iECBD_1354.ECBD_1731,iECB_1328.ECB_01877,iECDH10B_1368.ECDH10B_2053,iECDH1ME8569_1439.ECDH1ME8569_1852,iECD_1391.ECD_01877,iECED1_1282.ECED1_2177,iECH74115_1262.ECH74115_2684,iECIAI1_1343.ECIAI1_1996,iECIAI39_1322.ECIAI39_1143,iECNA114_1301.ECNA114_2003,iECO103_1326.ECO103_2168,iECO111_1330.ECO111_2492,iECO26_1355.ECO26_2804,iECOK1_1307.ECOK1_2029,iECP_1309.ECP_1852,iECS88_1305.ECS88_1966,iECSF_1327.ECSF_1764,iECSP_1301.ECSP_2516,iECUMN_1333.ECUMN_2204,iECs_1301.ECs2650,iETEC_1333.ETEC_2020,iEcDH1_1363.EcDH1_1734,iEcE24377_1341.EcE24377A_2145,iEcHS_1320.EcHS_A2010,iEcSMS35_1347.EcSMS35_1271,iEcolC_1368.EcolC_1727,iG2583_1286.G2583_2363,iJO1366.b1912,iJR904.b1912,iLF82_1304.LF82_1635,iNRG857_1313.NRG857_09550,iSDY_1059.SDY_1106,iSSON_1240.SSON_1206,iSbBS512_1146.SbBS512_E1039,iUMN146_1321.UM146_07620,iUMNK88_1353.UMNK88_2386,iUTI89_1310.UTI89_C2113,iY75_1357.Y75_RS10025,iYL1228.KPN_02410,iZ_1308.Z3000,ic_1306.c2325 CDP-OH_P_transf k59_1268265_1 929703.KE386491_gene4237 1.47e-21 94.0 COG1475@1|root,COG1475@2|Bacteria,4NFZ9@976|Bacteroidetes,47K9I@768503|Cytophagia 976|Bacteroidetes K Belongs to the ParB family parB - - ko:K03497 - - - - ko00000,ko03000,ko03036,ko04812 - - - ParBc k59_85431_1 1552758.NC00_03100 1.28e-94 292.0 2AQ16@1|root,31F66@2|Bacteria,1RKKN@1224|Proteobacteria,1S59T@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_28337_1 272123.Anacy_4372 4.05e-64 205.0 COG3039@1|root,COG3039@2|Bacteria,1G1EK@1117|Cyanobacteria,1HNK2@1161|Nostocales 1117|Cyanobacteria L Transposase DDE domain - - - - - - - - - - - - DDE_Tnp_1_3 k59_1554243_2 857087.Metme_0750 3.85e-18 80.9 COG0801@1|root,COG0801@2|Bacteria,1RHNN@1224|Proteobacteria,1S62M@1236|Gammaproteobacteria,1XF75@135618|Methylococcales 135618|Methylococcales H PFAM 7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK - - 2.7.6.3 ko:K00950 ko00790,ko01100,map00790,map01100 M00126,M00841 R03503 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - HPPK k59_1384198_1 1159870.KB907784_gene393 6.69e-18 84.3 COG1304@1|root,COG1304@2|Bacteria,1MUEZ@1224|Proteobacteria,2VHZV@28216|Betaproteobacteria 28216|Betaproteobacteria C Dehydrogenase - - 1.1.99.31 ko:K15054 ko00627,ko01120,map00627,map01120 - R04160,R07664 RC00240 ko00000,ko00001,ko01000 - - - FMN_dh k59_421658_1 1122137.AQXF01000005_gene1048 4.84e-09 56.6 COG1609@1|root,COG1609@2|Bacteria,1MW7E@1224|Proteobacteria,2U1NM@28211|Alphaproteobacteria 28211|Alphaproteobacteria K transcriptional regulator - - - - - - - - - - - - LacI,Peripla_BP_3 k59_592440_1 745310.G432_06455 6.09e-128 377.0 COG3534@1|root,COG3534@2|Bacteria,1PPWJ@1224|Proteobacteria,2TWSD@28211|Alphaproteobacteria,2K23Z@204457|Sphingomonadales 204457|Sphingomonadales G Alpha-L-arabinofuranosidase - - 3.2.1.55 ko:K01209 ko00520,map00520 - R01762 - ko00000,ko00001,ko01000 - GH51 - Alpha-L-AF_C k59_1722781_2 95619.PM1_0201870 3.07e-68 210.0 COG0219@1|root,COG0219@2|Bacteria,1RCY4@1224|Proteobacteria,1S3PI@1236|Gammaproteobacteria 1236|Gammaproteobacteria J Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide trmL GO:0001510,GO:0002128,GO:0002130,GO:0002131,GO:0002132,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016300,GO:0016427,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042802,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0052665,GO:0052666,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.1.1.207 ko:K03216 - - - - ko00000,ko01000,ko03016 - - - SpoU_methylase k59_1722781_3 1279019.ARQK01000022_gene162 1.15e-94 285.0 COG0167@1|root,COG0167@2|Bacteria,1MU7C@1224|Proteobacteria,1T02D@1236|Gammaproteobacteria,1WW5T@135613|Chromatiales 135613|Chromatiales F Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily pyrD - 1.3.1.14 ko:K17828 ko00240,ko01100,map00240,map01100 M00051 R01869 RC00051 ko00000,ko00001,ko00002,ko01000 - - - DHO_dh k59_310972_2 1219065.VPR01S_13_00170 2.71e-12 61.6 2EK1G@1|root,33DRY@2|Bacteria,1NH6C@1224|Proteobacteria,1SGMZ@1236|Gammaproteobacteria,1XYPN@135623|Vibrionales 135623|Vibrionales S Protein of unknown function (DUF3012) - - - - - - - - - - - - DUF3012 k59_936279_2 316407.85676713 1.38e-21 87.0 COG2165@1|root,COG2165@2|Bacteria,1RDX2@1224|Proteobacteria,1S3VS@1236|Gammaproteobacteria,3XPD0@561|Escherichia 1236|Gammaproteobacteria U General secretion pathway protein gspG GO:0002790,GO:0006810,GO:0008104,GO:0008150,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0032940,GO:0033036,GO:0042886,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0071702,GO:0071705 - ko:K02456 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - N_methyl,T2SSG k59_766244_1 1453501.JELR01000002_gene611 1.51e-57 187.0 COG0494@1|root,COG0494@2|Bacteria,1RDMW@1224|Proteobacteria,1RPZV@1236|Gammaproteobacteria,4670F@72275|Alteromonadaceae 1236|Gammaproteobacteria L COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes nudF GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0019144,GO:0043167,GO:0043169,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0047631,GO:0050896 3.6.1.13 ko:K01515 ko00230,map00230 - R01054 RC00002 ko00000,ko00001,ko01000 - - iECP_1309.ECP_3126 NUDIX k59_1729611_1 313606.M23134_03202 1.27e-67 230.0 COG0330@1|root,COG0330@2|Bacteria,4NKQ8@976|Bacteroidetes,47TJM@768503|Cytophagia 976|Bacteroidetes O Shoulder domain - - - ko:K17266 - - - - ko00000,ko04147 - - - MVP_shoulder k59_825190_1 313596.RB2501_04450 9.42e-83 261.0 COG0810@1|root,COG0810@2|Bacteria,4NWD2@976|Bacteroidetes,1I57H@117743|Flavobacteriia 976|Bacteroidetes M Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins - - - - - - - - - - - - - k59_1053558_1 398767.Glov_1341 8.57e-17 74.3 COG0048@1|root,COG0048@2|Bacteria,1RCWY@1224|Proteobacteria,42RDQ@68525|delta/epsilon subdivisions,2WND8@28221|Deltaproteobacteria,43URA@69541|Desulfuromonadales 28221|Deltaproteobacteria J With S4 and S5 plays an important role in translational accuracy rpsL - - ko:K02950 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosom_S12_S23 k59_1053558_2 338963.Pcar_0695 1.14e-35 136.0 COG0086@1|root,COG0086@2|Bacteria,1MU3M@1224|Proteobacteria,42NAW@68525|delta/epsilon subdivisions,2WISU@28221|Deltaproteobacteria,43S5H@69541|Desulfuromonadales 28221|Deltaproteobacteria K RNA polymerase I subunit A N-terminus rpoC - 2.7.7.6 ko:K03046 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5 k59_1781754_2 408672.NBCG_00880 3.11e-72 224.0 COG0745@1|root,COG0745@2|Bacteria,2GIZB@201174|Actinobacteria,4DP6U@85009|Propionibacteriales 201174|Actinobacteria T Transcriptional regulatory protein, C terminal mprA GO:0000160,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006355,GO:0007154,GO:0007165,GO:0008150,GO:0009268,GO:0009628,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0010446,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0016020,GO:0019219,GO:0019222,GO:0023052,GO:0030312,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0035556,GO:0043254,GO:0044087,GO:0044464,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0051716,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:0090034,GO:0097159,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:2000112,GO:2000113,GO:2001141 - ko:K07669,ko:K07672 ko02020,map02020 M00460,M00463 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Trans_reg_C k59_1729633_1 1122137.AQXF01000006_gene918 4.12e-84 261.0 COG3146@1|root,COG3146@2|Bacteria,1MU35@1224|Proteobacteria,2TS5I@28211|Alphaproteobacteria 28211|Alphaproteobacteria S protein conserved in bacteria MA20_36195 - - ko:K09919 - - - - ko00000 - - - FemAB_like k59_1617068_1 391603.FBALC1_08183 5.95e-80 263.0 COG1472@1|root,COG1680@1|root,COG1472@2|Bacteria,COG1680@2|Bacteria,4NET8@976|Bacteroidetes,1HX49@117743|Flavobacteriia 976|Bacteroidetes G hydrolase, family 3 nagA - - - - - - - - - - - Beta-lactamase,Glyco_hydro_3,Glyco_hydro_3_C k59_715093_1 931276.Cspa_c42840 6.64e-20 90.9 COG2211@1|root,COG2211@2|Bacteria,1TRA5@1239|Firmicutes,24ABB@186801|Clostridia,36E3W@31979|Clostridiaceae 186801|Clostridia G transporter - - - ko:K03292 - - - - ko00000 2.A.2 - - MFS_2 k59_715093_2 634177.GLX_01970 8.56e-61 205.0 COG2303@1|root,COG2303@2|Bacteria,1MU3F@1224|Proteobacteria,2TT3C@28211|Alphaproteobacteria,2JRMB@204441|Rhodospirillales 204441|Rhodospirillales E GMC oxidoreductase - - - - - - - - - - - - FAD_binding_2,GMC_oxred_C,GMC_oxred_N k59_1331640_1 1123371.ATXH01000013_gene1534 1.09e-66 216.0 COG1624@1|root,COG1624@2|Bacteria,2GGVH@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria S Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria dacA - 2.7.7.85 ko:K18672 - - - - ko00000,ko01000 - - - DisA_N k59_1331640_2 207559.Dde_1513 2.02e-196 567.0 COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,42M4Z@68525|delta/epsilon subdivisions,2WJ0D@28221|Deltaproteobacteria,2M88M@213115|Desulfovibrionales 28221|Deltaproteobacteria O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins ftsH - - ko:K03798 - M00742 - - ko00000,ko00002,ko01000,ko01002,ko03110 - - - AAA,FtsH_ext,Peptidase_M41 k59_936307_1 436308.Nmar_0701 6.59e-111 336.0 COG0365@1|root,arCOG04201@2157|Archaea 2157|Archaea I COG0365 Acyl-coenzyme A synthetases AMP-(fatty) acid ligases acsA - 6.2.1.1 ko:K01895 ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200 M00357 R00235,R00236,R00316,R00926,R01354 RC00004,RC00012,RC00043,RC00070,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000,ko01004 - - - ACAS_N,AMP-binding,AMP-binding_C k59_991826_2 402626.Rpic_4133 4.63e-09 61.2 COG3735@1|root,COG3735@2|Bacteria,1MVCW@1224|Proteobacteria,2VQAJ@28216|Betaproteobacteria 28216|Betaproteobacteria S PFAM GumN family protein - - - ko:K09973 - - - - ko00000 - - - TraB k59_377078_1 1122137.AQXF01000002_gene142 3.07e-244 695.0 COG4775@1|root,COG4775@2|Bacteria,1MU0D@1224|Proteobacteria,2TR7W@28211|Alphaproteobacteria 28211|Alphaproteobacteria M Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane bamA - - ko:K07277 - - - - ko00000,ko02000,ko03029 1.B.33 - - Bac_surface_Ag,POTRA k59_1106155_1 641526.ADIWIN_0067 2.55e-91 299.0 COG3291@1|root,COG4932@1|root,COG3291@2|Bacteria,COG4932@2|Bacteria,4NDZQ@976|Bacteroidetes,1HX5A@117743|Flavobacteriia 976|Bacteroidetes M C-terminal domain of CHU protein family - - - - - - - - - - - - CHU_C,HYR,PKD,SprB k59_147128_1 261292.Nit79A3_0075 8.34e-93 292.0 COG1166@1|root,COG1166@2|Bacteria,1MU80@1224|Proteobacteria,2VNM0@28216|Betaproteobacteria,37405@32003|Nitrosomonadales 28216|Betaproteobacteria H PFAM Orn DAP Arg decarboxylase 2 speA - 4.1.1.19 ko:K01585 ko00330,ko01100,map00330,map01100 M00133 R00566 RC00299 ko00000,ko00001,ko00002,ko01000 - - - Orn_Arg_deC_N k59_1506743_1 232721.Ajs_3203 3.33e-37 140.0 COG0303@1|root,COG0303@2|Bacteria,1MVD5@1224|Proteobacteria,2VIFK@28216|Betaproteobacteria,4AB3M@80864|Comamonadaceae 28216|Betaproteobacteria H MoeA domain protein domain I and II moeA1 - 2.10.1.1 ko:K03750 ko00790,ko01100,map00790,map01100 - R09735 RC03462 ko00000,ko00001,ko01000 - - - MoCF_biosynth,MoeA_C,MoeA_N k59_377080_1 1282876.BAOK01000001_gene3450 2.59e-124 374.0 COG1752@1|root,COG1752@2|Bacteria,1N5SK@1224|Proteobacteria,2UP09@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Domain of unknown function (DUF3336) - - - ko:K07001 - - - - ko00000 - - - DUF3336,Patatin k59_377080_2 1205680.CAKO01000002_gene2357 1.09e-158 466.0 COG1884@1|root,COG2185@1|root,COG1884@2|Bacteria,COG2185@2|Bacteria,1MUXX@1224|Proteobacteria,2TQYC@28211|Alphaproteobacteria,2JP9C@204441|Rhodospirillales 204441|Rhodospirillales I Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly icmF - 5.4.99.2 ko:K01847 ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200 M00373,M00376,M00741 R00833 RC00395 ko00000,ko00001,ko00002,ko01000 - - - ArgK,B12-binding,MM_CoA_mutase k59_1106170_1 1121887.AUDK01000015_gene879 3.51e-16 75.9 COG3184@1|root,COG3184@2|Bacteria,4NSCK@976|Bacteroidetes,1I5E8@117743|Flavobacteriia,2NXBF@237|Flavobacterium 976|Bacteroidetes S Uncharacterized protein conserved in bacteria (DUF2059) - - - ko:K09924 - - - - ko00000 - - - DUF2059 k59_715127_1 1346791.M529_00770 1.16e-98 310.0 COG1472@1|root,COG1472@2|Bacteria,1MVIV@1224|Proteobacteria,2TS28@28211|Alphaproteobacteria,2JZVY@204457|Sphingomonadales 204457|Sphingomonadales G Belongs to the glycosyl hydrolase 3 family - - 3.2.1.21 ko:K05349 ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110 - R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040 RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248 ko00000,ko00001,ko01000 - GH3 - Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C k59_1617113_1 1197477.IA57_01115 4.53e-133 393.0 COG1960@1|root,COG1960@2|Bacteria,4NG2G@976|Bacteroidetes,1HXCS@117743|Flavobacteriia 976|Bacteroidetes I acyl-CoA dehydrogenase fadE - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_1564137_2 1122137.AQXF01000001_gene2996 6.18e-95 292.0 COG3307@1|root,COG3307@2|Bacteria,1PX0E@1224|Proteobacteria,2TT7I@28211|Alphaproteobacteria 28211|Alphaproteobacteria M polymerase - - - - - - - - - - - - Wzy_C k59_1444742_1 1239962.C943_02139 2.02e-11 65.9 COG1235@1|root,COG1235@2|Bacteria,4NM16@976|Bacteroidetes,47U32@768503|Cytophagia 976|Bacteroidetes S Beta-lactamase superfamily domain - - - - - - - - - - - - Lactamase_B_2 k59_1444742_2 317936.Nos7107_3725 2.26e-22 96.3 COG4292@1|root,COG4292@2|Bacteria,1G40Y@1117|Cyanobacteria,1HIDE@1161|Nostocales 1117|Cyanobacteria S PFAM Bacterial low temperature requirement A protein (LtrA) - - - - - - - - - - - - LtrA k59_1617115_1 1229909.NSED_08335 7.24e-144 419.0 COG2304@1|root,arCOG02900@2157|Archaea,41SDY@651137|Thaumarchaeota 651137|Thaumarchaeota S von Willebrand factor (vWF) type A domain - - - - - - - - - - - - - k59_936343_1 1122137.AQXF01000003_gene2238 2.44e-59 202.0 COG0642@1|root,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria 1224|Proteobacteria T Histidine kinase rpfC - 2.7.13.3 ko:K10715 ko02020,ko02024,map02020,map02024 M00517 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA,Hpt,PAS,PAS_3,PAS_9,Response_reg k59_654016_1 765913.ThidrDRAFT_4170 1.29e-110 338.0 COG0449@1|root,COG0449@2|Bacteria,1MW4K@1224|Proteobacteria,1RMVN@1236|Gammaproteobacteria,1WW41@135613|Chromatiales 135613|Chromatiales M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source glmS - 2.6.1.16 ko:K00820 ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931 - R00768 RC00010,RC00163,RC02752 ko00000,ko00001,ko01000,ko01002 - - - GATase_6,SIS k59_1165416_1 1173027.Mic7113_1640 1.14e-53 179.0 COG0581@1|root,COG0581@2|Bacteria,1G1S1@1117|Cyanobacteria,1HH64@1150|Oscillatoriales 1117|Cyanobacteria P PFAM Binding-protein-dependent transport system inner membrane component - - - ko:K02038 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - BPD_transp_1 k59_1165416_2 472759.Nhal_2980 6.69e-106 317.0 COG0573@1|root,COG0573@2|Bacteria,1MVKP@1224|Proteobacteria,1RQXJ@1236|Gammaproteobacteria,1WWUX@135613|Chromatiales 135613|Chromatiales P probably responsible for the translocation of the substrate across the membrane - - - ko:K02037 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - BPD_transp_1 k59_1165416_3 1541065.JRFE01000003_gene5351 2.2e-48 164.0 COG0226@1|root,COG0226@2|Bacteria,1G0JS@1117|Cyanobacteria 1117|Cyanobacteria P Phosphate ABC transporter substrate-binding protein, PhoT family - - - ko:K02040 ko02010,ko02020,ko05152,map02010,map02020,map05152 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - PBP_like_2 k59_1393797_3 1229909.NSED_03885 2.01e-10 57.4 arCOG10587@1|root,arCOG10587@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_825258_1 1122137.AQXF01000003_gene2173 1.32e-214 622.0 COG0643@1|root,COG0643@2|Bacteria,1MUAG@1224|Proteobacteria,2TSN2@28211|Alphaproteobacteria 28211|Alphaproteobacteria T Histidine kinase cheA - 2.7.13.3 ko:K03407 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 - - - CheW,H-kinase_dim,HATPase_c,Hpt,Response_reg k59_1564157_1 1177928.TH2_06298 4.18e-106 328.0 COG0006@1|root,COG0006@2|Bacteria,1MUZS@1224|Proteobacteria,2TQXN@28211|Alphaproteobacteria,2JQSS@204441|Rhodospirillales 204441|Rhodospirillales E aminopeptidase pepP - 3.4.11.9 ko:K01262 - - - - ko00000,ko01000,ko01002 - - - Creatinase_N,Creatinase_N_2,Peptidase_M24,Peptidase_M24_C k59_1564157_2 1122137.AQXF01000004_gene1711 1.54e-83 248.0 COG1765@1|root,COG1765@2|Bacteria,1RCZW@1224|Proteobacteria,2U9G3@28211|Alphaproteobacteria 28211|Alphaproteobacteria O redox protein regulator of disulfide bond formation yhfA - - ko:K07397 - - - - ko00000 - - - OsmC k59_1729717_1 1298593.TOL_0894 9.82e-37 142.0 COG1858@1|root,COG1858@2|Bacteria,1MV70@1224|Proteobacteria,1RPPQ@1236|Gammaproteobacteria,1XIQI@135619|Oceanospirillales 135619|Oceanospirillales C Cytochrome c peroxidase - - 1.11.1.5 ko:K00428 - - - - ko00000,ko01000 - - - CCP_MauG,UnbV_ASPIC,VCBS k59_1331690_1 1296415.JACC01000029_gene2715 2.68e-17 75.9 COG1476@1|root,COG1476@2|Bacteria,4PPVF@976|Bacteroidetes,1IKV2@117743|Flavobacteriia,2YK5A@290174|Aquimarina 976|Bacteroidetes K TRANSCRIPTIONal - - - - - - - - - - - - - k59_1053654_1 67275.JOAP01000042_gene7851 1.52e-91 278.0 COG0183@1|root,COG0183@2|Bacteria,2GKFR@201174|Actinobacteria 201174|Actinobacteria I lipid-transfer protein ltp2 - - - - - - - - - - - Thiolase_N k59_1444775_1 748658.KB907319_gene727 7.13e-45 159.0 COG0438@1|root,COG0438@2|Bacteria,1R564@1224|Proteobacteria,1S0XW@1236|Gammaproteobacteria,1WXQE@135613|Chromatiales 135613|Chromatiales M PFAM Glycosyl transferases group 1 - - - - - - - - - - - - Glyco_transf_4,Glycos_transf_1 k59_1444775_2 1121015.N789_11280 6.34e-73 228.0 COG0463@1|root,COG0463@2|Bacteria,1MXC1@1224|Proteobacteria,1RRHP@1236|Gammaproteobacteria,1X33S@135614|Xanthomonadales 135614|Xanthomonadales M PFAM Glycosyl transferase family 2 - - - - - - - - - - - - Glycos_transf_2 k59_483881_1 999411.HMPREF1092_01175 2.55e-32 123.0 COG0012@1|root,COG0012@2|Bacteria,1TPRK@1239|Firmicutes,2482Z@186801|Clostridia,36E7J@31979|Clostridiaceae 186801|Clostridia J ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner ychF - - ko:K06942 - - - - ko00000,ko03009 - - - MMR_HSR1,YchF-GTPase_C k59_483881_2 867845.KI911784_gene1105 2.75e-14 71.6 COG2189@1|root,COG2189@2|Bacteria,2G7K2@200795|Chloroflexi,3756B@32061|Chloroflexia 32061|Chloroflexia L DNA methylase - - 2.1.1.72 ko:K00571 - - - - ko00000,ko01000,ko02048 - - - N6_N4_Mtase k59_1444777_1 400668.Mmwyl1_4035 2e-64 210.0 COG0505@1|root,COG0505@2|Bacteria,1MUB9@1224|Proteobacteria,1RMAW@1236|Gammaproteobacteria,1XHDH@135619|Oceanospirillales 135619|Oceanospirillales F carbamoyl-phosphate synthetase glutamine chain carA - 6.3.5.5 ko:K01956 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - - CPSase_sm_chain,GATase k59_825276_2 1122963.AUHB01000017_gene1949 3.75e-64 212.0 COG0507@1|root,COG0507@2|Bacteria,1R1AT@1224|Proteobacteria,2U1ZX@28211|Alphaproteobacteria 28211|Alphaproteobacteria L A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD - - - - - - - - - - - - Terminase_6 k59_715175_1 1121921.KB898707_gene998 1.57e-57 184.0 COG0071@1|root,COG0071@2|Bacteria,1RH2X@1224|Proteobacteria,1S6WS@1236|Gammaproteobacteria,2PNHV@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria O Hsp20/alpha crystallin family ibpA GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0042802,GO:0044424,GO:0044444,GO:0044464,GO:0050896 - ko:K04080 - - - - ko00000,ko03110 - - - HSP20 k59_1444784_1 317025.Tcr_2156 8.93e-15 74.7 COG1595@1|root,COG1595@2|Bacteria,1MZMC@1224|Proteobacteria,1S3GT@1236|Gammaproteobacteria 1236|Gammaproteobacteria K Belongs to the sigma-70 factor family. ECF subfamily - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 k59_1671713_1 1168065.DOK_15194 3.69e-61 208.0 COG0754@1|root,COG0754@2|Bacteria,1MW6V@1224|Proteobacteria,1RQAP@1236|Gammaproteobacteria,1J6UT@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E COG0754 Glutathionylspermidine synthase gsp GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008884,GO:0008885,GO:0016787,GO:0016810,GO:0016811,GO:0016874,GO:0016879,GO:0016880,GO:0044424,GO:0044444,GO:0044464 3.5.1.78,6.3.1.8 ko:K01460 ko00480,ko01100,map00480,map01100 - R01917,R01918 RC00090,RC00096 ko00000,ko00001,ko01000 - - iECIAI39_1322.ECIAI39_3484 CHAP,GSP_synth k59_602181_1 1232683.ADIMK_0681 1.76e-115 345.0 COG0031@1|root,COG0031@2|Bacteria,1MUBE@1224|Proteobacteria,1RN6J@1236|Gammaproteobacteria,4641I@72275|Alteromonadaceae 1236|Gammaproteobacteria E Belongs to the cysteine synthase cystathionine beta- synthase family cysK - 2.5.1.47 ko:K01738 ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230 M00021 R00897,R03601,R04859 RC00020,RC02814,RC02821 ko00000,ko00001,ko00002,ko01000 - - - Glutaredoxin,PALP k59_936397_1 867845.KI911784_gene3726 6e-28 114.0 COG0045@1|root,COG1042@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,2G5QB@200795|Chloroflexi,3756Y@32061|Chloroflexia 32061|Chloroflexia C TIGRFAM acetyl coenzyme A synthetase (ADP forming), alpha domain - - 6.2.1.13 ko:K01905,ko:K22224 ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120 - R00229,R00920 RC00004,RC00012,RC00014 ko00000,ko00001,ko01000,ko01004 - - - ATP-grasp_5,CoA_binding_2,Succ_CoA_lig k59_936397_2 326297.Sama_0626 1.85e-08 56.2 COG0526@1|root,COG0526@2|Bacteria,1MWDE@1224|Proteobacteria,1S0NV@1236|Gammaproteobacteria,2Q99W@267890|Shewanellaceae 1236|Gammaproteobacteria CO Cytochrome C biogenesis protein - - - - - - - - - - - - Glutaredoxin k59_204893_1 1346791.M529_21295 7.55e-91 286.0 COG0449@1|root,COG0449@2|Bacteria,1MW4K@1224|Proteobacteria,2TQPM@28211|Alphaproteobacteria,2K017@204457|Sphingomonadales 204457|Sphingomonadales M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source glmS - 2.6.1.16 ko:K00820 ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931 - R00768 RC00010,RC00163,RC02752 ko00000,ko00001,ko01000,ko01002 - - - GATase_6,SIS k59_204893_2 1202962.KB907166_gene2095 2.94e-82 255.0 2DBI0@1|root,2Z9E1@2|Bacteria,1PWHV@1224|Proteobacteria,1RY46@1236|Gammaproteobacteria 1236|Gammaproteobacteria L PFAM TnsA endonuclease tnsA - - - - - - - - - - - Tn7_Tnp_TnsA_C,Tn7_Tnp_TnsA_N k59_204893_3 520709.F985_00086 4.92e-49 180.0 COG2801@1|root,COG2801@2|Bacteria,1PDVT@1224|Proteobacteria,1RQCZ@1236|Gammaproteobacteria,3NSSF@468|Moraxellaceae 1236|Gammaproteobacteria L Integrase core domain tnsB - - - - - - - - - - - Mu-transpos_C,rve k59_1165484_1 382464.ABSI01000005_gene1073 1.84e-90 283.0 COG1069@1|root,COG1069@2|Bacteria,46UI3@74201|Verrucomicrobia,2ITGU@203494|Verrucomicrobiae 203494|Verrucomicrobiae C FGGY family of carbohydrate kinases, C-terminal domain - - - - - - - - - - - - FGGY_C,FGGY_N k59_1106242_2 1122137.AQXF01000001_gene2715 1.99e-44 155.0 COG1670@1|root,COG1670@2|Bacteria 2|Bacteria J COG1670 acetyltransferases, including N-acetylases of ribosomal proteins - - 3.6.1.55 ko:K03574 - - - - ko00000,ko01000,ko03400 - - - Acetyltransf_3,NUDIX,NUDIX_4 k59_1671730_1 264198.Reut_B4249 1.74e-23 103.0 COG0491@1|root,COG0491@2|Bacteria,1MVC3@1224|Proteobacteria,2VICE@28216|Betaproteobacteria 28216|Betaproteobacteria L NUDIX hydrolase - - - - - - - - - - - - Lactamase_B,NUDIX k59_262370_1 565045.NOR51B_1833 1.56e-35 134.0 COG2010@1|root,COG3420@1|root,COG2010@2|Bacteria,COG3420@2|Bacteria,1QUPB@1224|Proteobacteria,1T2I7@1236|Gammaproteobacteria,1J4SI@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C COG3420 Nitrous oxidase accessory protein - - - - - - - - - - - - Beta_helix,NosD k59_262370_2 634177.GLX_27910 8.08e-10 62.0 COG1028@1|root,COG1028@2|Bacteria,1MUPX@1224|Proteobacteria,2TT6C@28211|Alphaproteobacteria,2JS3E@204441|Rhodospirillales 204441|Rhodospirillales IQ Enoyl-(Acyl carrier protein) reductase - - - - - - - - - - - - adh_short_C2 k59_1506835_2 1196835.A458_08725 2.17e-43 152.0 COG0604@1|root,COG0604@2|Bacteria,1QUNT@1224|Proteobacteria,1T25R@1236|Gammaproteobacteria,1Z05V@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria C Protein of unknown function (DUF2855) - - - - - - - - - - - - DUF2855 k59_602201_1 1280001.BAOA01000021_gene829 4.13e-38 149.0 COG1452@1|root,COG1452@2|Bacteria,1MUJC@1224|Proteobacteria,1RQEX@1236|Gammaproteobacteria,1XSAA@135623|Vibrionales 135623|Vibrionales M Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane lptD GO:0008150,GO:0009636,GO:0042221,GO:0050896 - ko:K04744 - - - - ko00000,ko02000 1.B.42.1 - - OstA,OstA_C k59_539001_1 1207055.C100_16845 1.12e-99 317.0 COG4774@1|root,COG4774@2|Bacteria,1R5EH@1224|Proteobacteria,2U458@28211|Alphaproteobacteria,2K054@204457|Sphingomonadales 204457|Sphingomonadales P TonB dependent receptor - - - - - - - - - - - - Plug,TonB_dep_Rec k59_1393859_1 1229909.NSED_07065 4.22e-53 179.0 COG1027@1|root,arCOG01750@2157|Archaea,41S9C@651137|Thaumarchaeota 651137|Thaumarchaeota E Fumarase C C-terminus - - 4.3.1.1 ko:K01744 ko00250,ko01100,map00250,map01100 - R00490 RC00316,RC02799 ko00000,ko00001,ko01000 - - - FumaraseC_C,Lyase_1 k59_1393859_2 436308.Nmar_1667 2.99e-10 60.5 COG2132@1|root,arCOG03914@2157|Archaea,41SZT@651137|Thaumarchaeota 651137|Thaumarchaeota Q Multicopper oxidase - - 1.7.2.1 ko:K00368 ko00910,ko01120,map00910,map01120 M00529 R00783,R00785 RC00086 ko00000,ko00001,ko00002,ko01000 - - - Cu-oxidase_3 k59_539004_1 436308.Nmar_0926 2.27e-97 300.0 COG0441@1|root,arCOG00401@2157|Archaea,41S9K@651137|Thaumarchaeota 651137|Thaumarchaeota J Belongs to the class-II aminoacyl-tRNA synthetase family thrS - 6.1.1.3 ko:K01868 ko00970,map00970 M00359,M00360 R03663 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,tRNA-Thr_ED,tRNA-synt_2b k59_825332_1 1088721.NSU_3864 5.14e-99 290.0 COG1051@1|root,COG1051@2|Bacteria,1QU0T@1224|Proteobacteria,2TW25@28211|Alphaproteobacteria,2K4S3@204457|Sphingomonadales 204457|Sphingomonadales F Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage nudH - - ko:K08311 ko03018,map03018 - R10816 RC00002 ko00000,ko00001,ko01000,ko03019 - - - NUDIX k59_1106271_1 410359.Pcal_0884 0.000414 42.7 COG1051@1|root,arCOG01075@2157|Archaea 2157|Archaea F Nudix hydrolase - - 3.6.1.13,3.6.1.55 ko:K01515,ko:K03574 ko00230,map00230 - R01054 RC00002 ko00000,ko00001,ko01000,ko03400 - - - NUDIX k59_602225_1 1122194.AUHU01000003_gene2143 1.54e-52 174.0 COG0330@1|root,COG0330@2|Bacteria,1MUM8@1224|Proteobacteria,1RNW8@1236|Gammaproteobacteria,465XW@72275|Alteromonadaceae 1236|Gammaproteobacteria O COG0330 Membrane protease subunits, stomatin prohibitin homologs qmcA GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - - - - - - - - - - Band_7,Band_7_C k59_602225_2 1283300.ATXB01000001_gene2407 1.33e-26 101.0 COG1585@1|root,COG1585@2|Bacteria,1N3KQ@1224|Proteobacteria,1SACR@1236|Gammaproteobacteria 1236|Gammaproteobacteria OU NfeD-like C-terminal, partner-binding - - - - - - - - - - - - NfeD k59_1564248_1 570967.JMLV01000002_gene1971 3.3e-68 231.0 COG0145@1|root,COG0146@1|root,COG0145@2|Bacteria,COG0146@2|Bacteria,1MU2Y@1224|Proteobacteria,2TQZ6@28211|Alphaproteobacteria,2JQPR@204441|Rhodospirillales 204441|Rhodospirillales EQ Hydantoinase/oxoprolinase N-terminal region - - 3.5.2.9 ko:K01469 ko00480,map00480 - R00251 RC00553 ko00000,ko00001,ko01000 - - - Hydant_A_N,Hydantoinase_A,Hydantoinase_B k59_93299_1 1229909.NSED_03915 1.06e-75 239.0 arCOG08742@1|root,arCOG08742@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_483945_1 159087.Daro_2493 2.59e-15 73.2 COG1416@1|root,COG1416@2|Bacteria,1RHW0@1224|Proteobacteria,2VWXN@28216|Betaproteobacteria 28216|Betaproteobacteria S DsrE/DsrF-like family - - - ko:K09004 - - - - ko00000 - - - DrsE k59_1506857_1 1472716.KBK24_0102615 3.25e-66 218.0 COG0405@1|root,COG0405@2|Bacteria,1MUV6@1224|Proteobacteria,2VH8Z@28216|Betaproteobacteria,1JZW1@119060|Burkholderiaceae 28216|Betaproteobacteria E gamma-glutamyltransferase - - 2.3.2.2,3.4.19.13 ko:K00681 ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100 - R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935 RC00064,RC00090,RC00096 ko00000,ko00001,ko01000,ko01002 - - - G_glu_transpept k59_539016_1 983920.Y88_2136 2.58e-32 116.0 COG2005@1|root,COG2005@2|Bacteria,1P9SX@1224|Proteobacteria,2UC9Q@28211|Alphaproteobacteria 28211|Alphaproteobacteria H Transcriptional regulator, ModE family modE - - ko:K02019 - - - - ko00000,ko03000 - - - HTH_1 k59_38557_1 999141.GME_05045 9.67e-65 217.0 COG0642@1|root,COG2205@2|Bacteria,1MXH7@1224|Proteobacteria,1RQZW@1236|Gammaproteobacteria,1XJBY@135619|Oceanospirillales 135619|Oceanospirillales T Histidine kinase-like ATPases - - - - - - - - - - - - HAMP,HATPase_c,HisKA k59_492864_2 1385517.N800_06525 4.07e-74 237.0 COG1492@1|root,COG1492@2|Bacteria,1MUFY@1224|Proteobacteria,1RP8G@1236|Gammaproteobacteria,1X4YQ@135614|Xanthomonadales 135614|Xanthomonadales H Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation cobQ - 6.3.5.10 ko:K02232 ko00860,ko01100,map00860,map01100 M00122 R05225 RC00010,RC01302 ko00000,ko00001,ko00002,ko01000 - - - CbiA,GATase_3 k59_1001300_2 757424.Hsero_2187 2.53e-12 67.0 COG2825@1|root,COG2825@2|Bacteria,1RD8X@1224|Proteobacteria,2VRZI@28216|Betaproteobacteria,474EF@75682|Oxalobacteraceae 28216|Betaproteobacteria M Belongs to the skp family ompH - - ko:K06142 - - - - ko00000 - - - OmpH k59_548345_1 1121937.AUHJ01000008_gene1997 8.28e-48 175.0 COG1391@1|root,COG1391@2|Bacteria,1MU4I@1224|Proteobacteria,1RP9N@1236|Gammaproteobacteria,464DC@72275|Alteromonadaceae 1236|Gammaproteobacteria H Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell glnE GO:0000166,GO:0000287,GO:0000820,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006521,GO:0006541,GO:0006542,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0008882,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0010565,GO:0016053,GO:0016740,GO:0016772,GO:0016779,GO:0017076,GO:0019222,GO:0019752,GO:0030554,GO:0031323,GO:0032553,GO:0032555,GO:0032559,GO:0033238,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046872,GO:0050789,GO:0050794,GO:0051171,GO:0062012,GO:0065007,GO:0070566,GO:0071704,GO:0080090,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.7.42,2.7.7.89 ko:K00982 - - - - ko00000,ko01000 - - - GlnD_UR_UTase,GlnE k59_156418_1 926569.ANT_09550 3.02e-76 236.0 COG0714@1|root,COG0714@2|Bacteria,2G8BI@200795|Chloroflexi 200795|Chloroflexi S PFAM ATPase associated with various cellular activities, AAA_3 - - - ko:K03924 - - - - ko00000,ko01000 - - - AAA_3 k59_271643_1 1121374.KB891586_gene2863 1.53e-54 178.0 COG3959@1|root,COG3959@2|Bacteria,1MWRX@1224|Proteobacteria,1RS18@1236|Gammaproteobacteria 1236|Gammaproteobacteria G Transketolase tktB_2 - 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 - - - Transketolase_N k59_271644_1 395019.Bmul_3431 5.06e-55 179.0 COG3826@1|root,COG3826@2|Bacteria,1MWVV@1224|Proteobacteria,2VHMX@28216|Betaproteobacteria,1K0CT@119060|Burkholderiaceae 28216|Betaproteobacteria S Oxygenase, catalysing oxidative methylation of damaged DNA - - - ko:K09990 - - - - ko00000 - - - Oxygenase-NA k59_1738369_1 262316.MAP_2523c 7.29e-95 286.0 COG3804@1|root,COG3804@2|Bacteria,2IB8M@201174|Actinobacteria,236C9@1762|Mycobacteriaceae 201174|Actinobacteria S dihydrodipicolinate reductase - - - - - - - - - - - - DapB_N k59_492874_1 557598.LHK_02958 1.19e-11 63.9 COG0703@1|root,COG0703@2|Bacteria,1MUFJ@1224|Proteobacteria,2VRDN@28216|Betaproteobacteria,2KR45@206351|Neisseriales 206351|Neisseriales F Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate aroK - 2.7.1.71 ko:K00891 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02412 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - SKI k59_492874_2 1218075.BAYA01000022_gene5182 3.93e-36 134.0 COG0337@1|root,COG0337@2|Bacteria,1MUBK@1224|Proteobacteria,2VHXR@28216|Betaproteobacteria,1K17C@119060|Burkholderiaceae 28216|Betaproteobacteria E Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) aroB - 2.7.1.71,4.2.3.4 ko:K01735,ko:K13829 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02412,R03083 RC00002,RC00078,RC00847 ko00000,ko00001,ko00002,ko01000 - - - DHQ_synthase,SKI k59_1230136_1 222534.KB893728_gene5547 2.14e-77 244.0 COG1541@1|root,COG1541@2|Bacteria,2IANT@201174|Actinobacteria 201174|Actinobacteria H Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA) - - - - - - - - - - - - - k59_437254_1 1122137.AQXF01000004_gene1409 2.03e-99 311.0 COG0072@1|root,COG0072@2|Bacteria,1MWKS@1224|Proteobacteria,2TQV8@28211|Alphaproteobacteria 28211|Alphaproteobacteria J Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily pheT GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016070,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494 6.1.1.20 ko:K01890 ko00970,map00970 M00359,M00360 R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - B3_4,B5,FDX-ACB,tRNA_bind k59_1284408_1 882083.SacmaDRAFT_0458 5e-87 271.0 COG0318@1|root,COG0318@2|Bacteria,2GIUC@201174|Actinobacteria,4DXDJ@85010|Pseudonocardiales 201174|Actinobacteria IQ AMP-binding enzyme C-terminal domain - - - ko:K00666 - - - - ko00000,ko01000,ko01004 - - - AMP-binding,AMP-binding_C k59_834138_1 472759.Nhal_2510 7.52e-96 291.0 COG0604@1|root,COG0604@2|Bacteria,1MV3W@1224|Proteobacteria,1RMHG@1236|Gammaproteobacteria,1WX3U@135613|Chromatiales 135613|Chromatiales C PFAM Alcohol dehydrogenase - - 1.6.5.5 ko:K00344 - - - - ko00000,ko01000 - - - ADH_N,ADH_zinc_N k59_834138_2 215803.DB30_7910 5.64e-50 170.0 COG0491@1|root,COG0491@2|Bacteria,1MXKX@1224|Proteobacteria,42R8E@68525|delta/epsilon subdivisions,2WN6V@28221|Deltaproteobacteria,2YZHF@29|Myxococcales 28221|Deltaproteobacteria S Metallo-beta-lactamase superfamily - - - - - - - - - - - - Lactamase_B k59_213719_1 1242864.D187_010131 6.78e-39 138.0 COG0491@1|root,COG0491@2|Bacteria,1P5NJ@1224|Proteobacteria 1224|Proteobacteria S COG0491 Zn-dependent hydrolases, including glyoxylases - - 3.5.2.6 ko:K17837 ko01501,map01501 - R06363 RC01499 ko00000,ko00001,ko01000 - - - Lactamase_B k59_437261_1 1120956.JHZK01000057_gene1844 8.57e-30 115.0 COG2801@1|root,COG2801@2|Bacteria,1R471@1224|Proteobacteria,2U60M@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Integrase core domain - - - - - - - - - - - - HTH_21,rve,rve_3 k59_46127_1 748247.AZKH_2193 1.05e-21 99.0 COG2203@1|root,COG5001@1|root,COG2203@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,2KV1U@206389|Rhodocyclales 206389|Rhodocyclales T GGDEF domain - - - - - - - - - - - - EAL,GAF_2,GGDEF,PAS_9,Response_reg k59_663633_1 485915.Dret_2002 8.3e-89 273.0 COG3464@1|root,COG3464@2|Bacteria,1R4DH@1224|Proteobacteria,43AQ4@68525|delta/epsilon subdivisions,2X63W@28221|Deltaproteobacteria,2MGXP@213115|Desulfovibrionales 28221|Deltaproteobacteria L PFAM transposase IS204 IS1001 IS1096 IS1165 family protein - - - - - - - - - - - - DDE_Tnp_ISL3,zf-ISL3 k59_1738399_2 65497.JODV01000002_gene4192 3.76e-93 279.0 COG0745@1|root,COG0745@2|Bacteria,2GMVN@201174|Actinobacteria,4E0AP@85010|Pseudonocardiales 201174|Actinobacteria K Transcriptional regulatory protein, C terminal - - - - - - - - - - - - Response_reg,Trans_reg_C k59_1681169_1 95619.PM1_0201870 1.93e-58 186.0 COG0219@1|root,COG0219@2|Bacteria,1RCY4@1224|Proteobacteria,1S3PI@1236|Gammaproteobacteria 1236|Gammaproteobacteria J Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide trmL GO:0001510,GO:0002128,GO:0002130,GO:0002131,GO:0002132,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016300,GO:0016427,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042802,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0052665,GO:0052666,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.1.1.207 ko:K03216 - - - - ko00000,ko01000,ko03016 - - - SpoU_methylase k59_492901_1 930169.B5T_03316 3.15e-34 130.0 COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,1RNAM@1236|Gammaproteobacteria,1XIS2@135619|Oceanospirillales 135619|Oceanospirillales G COG1593 TRAP-type C4-dicarboxylate transport system, large permease component - - - - - - - - - - - - DctM k59_1515768_1 1122137.AQXF01000005_gene1127 3.51e-93 280.0 COG0761@1|root,COG0761@2|Bacteria,1MU7G@1224|Proteobacteria,2TRNR@28211|Alphaproteobacteria 28211|Alphaproteobacteria IM Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis ispH - 1.17.7.4 ko:K03527 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05884,R08210 RC01137,RC01487 ko00000,ko00001,ko00002,ko01000 - - - LYTB k59_213742_1 1121271.AUCM01000009_gene2177 7.25e-41 155.0 COG0557@1|root,COG0557@2|Bacteria,1MUS6@1224|Proteobacteria,2TRC1@28211|Alphaproteobacteria 28211|Alphaproteobacteria J 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs rnr GO:0000175,GO:0003674,GO:0003724,GO:0003824,GO:0004386,GO:0004518,GO:0004527,GO:0004532,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008408,GO:0008997,GO:0009056,GO:0009057,GO:0009266,GO:0009409,GO:0009628,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010605,GO:0010629,GO:0016070,GO:0016071,GO:0016462,GO:0016787,GO:0016788,GO:0016796,GO:0016817,GO:0016818,GO:0016896,GO:0017111,GO:0019222,GO:0019439,GO:0034458,GO:0034470,GO:0034641,GO:0034655,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0050896,GO:0060255,GO:0065007,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0140098,GO:1901360,GO:1901361,GO:1901575 - ko:K12573 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03016,ko03019 - - - RNB,S1 k59_213742_2 1122137.AQXF01000002_gene638 8.86e-307 858.0 COG0550@1|root,COG0550@2|Bacteria,1MUFZ@1224|Proteobacteria,2TRGN@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone topA - 5.99.1.2 ko:K03168 - - - - ko00000,ko01000,ko03032,ko03400 - - - Topoisom_bac,Toprim,Toprim_C_rpt,zf-C4_Topoisom k59_724675_1 595537.Varpa_2120 4.36e-117 343.0 COG1024@1|root,COG1024@2|Bacteria,1MXBB@1224|Proteobacteria,2VICM@28216|Betaproteobacteria,4AD3D@80864|Comamonadaceae 28216|Betaproteobacteria I Enoyl-CoA hydratase carnithine racemase - - - - - - - - - - - - ECH_1 k59_1001348_1 1116472.MGMO_137c00090 1.41e-103 306.0 COG0492@1|root,COG0492@2|Bacteria,1MV15@1224|Proteobacteria,1RMEX@1236|Gammaproteobacteria,1XDTQ@135618|Methylococcales 135618|Methylococcales C Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family trxB - 1.8.1.9 ko:K00384 ko00450,map00450 - R02016,R03596,R09372 RC00013,RC02518,RC02873 ko00000,ko00001,ko01000 - - - Pyr_redox_2 k59_1681203_1 555793.WSK_0865 6.59e-123 357.0 COG0714@1|root,COG0714@2|Bacteria,1MXIW@1224|Proteobacteria,2TS1Z@28211|Alphaproteobacteria,2K0S6@204457|Sphingomonadales 204457|Sphingomonadales S Aerobic cobaltochelatase subunit CobS - - 6.6.1.2 ko:K09882 ko00860,ko01100,map00860,map01100 - R05227 RC02000 ko00000,ko00001,ko01000 - - - AAA_5,CbbQ_C,CobS_N k59_437313_1 1122137.AQXF01000003_gene2003 1.02e-169 486.0 COG3724@1|root,COG3724@2|Bacteria,1MUJV@1224|Proteobacteria,2U0HD@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2) astB - 3.5.3.23 ko:K01484 ko00330,ko01100,map00330,map01100 - R04189 RC00024 ko00000,ko00001,ko01000 - - - AstB k59_1790843_1 1270193.JARP01000002_gene585 9.09e-10 59.7 COG0726@1|root,COG0726@2|Bacteria,4NM7D@976|Bacteroidetes,1I1DG@117743|Flavobacteriia,2NU6V@237|Flavobacterium 976|Bacteroidetes G polysaccharide deacetylase pgdA - 3.5.1.104 ko:K22278 - - - - ko00000,ko01000 - - - DUF3298,Polysacc_deac_1 k59_1790843_2 983544.Lacal_2088 3.19e-50 166.0 COG2834@1|root,COG2834@2|Bacteria,4NT30@976|Bacteroidetes,1I1BY@117743|Flavobacteriia 976|Bacteroidetes M outer membrane lipoprotein carrier protein LolA lolA - - ko:K03634 - - - - ko00000 - - - LolA k59_1230184_1 666681.M301_2425 4.44e-79 246.0 COG0472@1|root,COG0472@2|Bacteria,1MUTK@1224|Proteobacteria,2VHAP@28216|Betaproteobacteria,2KME5@206350|Nitrosomonadales 206350|Nitrosomonadales M First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan mraY - 2.7.8.13 ko:K01000 ko00550,ko01100,ko01502,map00550,map01100,map01502 - R05629,R05630 RC00002,RC02753 ko00000,ko00001,ko01000,ko01011 9.B.146 - - Glycos_transf_4,MraY_sig1 k59_894851_1 1229909.NSED_00450 1.66e-81 251.0 COG1819@1|root,arCOG01393@2157|Archaea,41T16@651137|Thaumarchaeota 651137|Thaumarchaeota G Glycosyltransferase family 28 C-terminal domain - - - - - - - - - - - - Glyco_tran_28_C k59_1001357_1 394.NGR_c00930 2.27e-19 89.0 COG2771@1|root,COG2771@2|Bacteria,1QU5E@1224|Proteobacteria,2TW0B@28211|Alphaproteobacteria 28211|Alphaproteobacteria K COG2771 DNA-binding HTH domain-containing proteins - - - - - - - - - - - - GerE k59_1573203_2 935565.JAEM01000022_gene3536 6.46e-26 112.0 COG2175@1|root,COG2175@2|Bacteria,1MV5K@1224|Proteobacteria,2TQTZ@28211|Alphaproteobacteria,2PXT8@265|Paracoccus 28211|Alphaproteobacteria Q Taurine catabolism dioxygenase TauD, TfdA family - - - - - - - - - - - - TauD k59_102043_1 100226.SCO1361 3.45e-56 185.0 COG3467@1|root,COG3467@2|Bacteria,2GJ76@201174|Actinobacteria 201174|Actinobacteria J Flavin-nucleotide-binding protein - - - ko:K07005 - - - - ko00000 - - - Pyridox_ox_2 k59_1115447_1 1123270.ATUR01000004_gene1673 1.61e-27 109.0 COG0019@1|root,COG0019@2|Bacteria,1MUA6@1224|Proteobacteria,2TQPB@28211|Alphaproteobacteria,2JZWD@204457|Sphingomonadales 204457|Sphingomonadales E Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine lysA - 4.1.1.20 ko:K01586 ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R00451 RC00299 ko00000,ko00001,ko00002,ko01000 - - - Orn_Arg_deC_N,Orn_DAP_Arg_deC k59_1115447_2 158500.BV97_04811 7.69e-28 104.0 293KA@1|root,2ZR29@2|Bacteria,1NKAC@1224|Proteobacteria,2UK1U@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_46183_1 1178825.ALIH01000007_gene1623 8.68e-98 296.0 COG0544@1|root,COG0544@2|Bacteria,4NE99@976|Bacteroidetes,1HX7I@117743|Flavobacteriia 976|Bacteroidetes O Trigger factor tig - - ko:K03545 - - - - ko00000 - - - Trigger_C,Trigger_N k59_1340774_1 317619.ANKN01000209_gene2275 4.42e-19 81.6 COG2343@1|root,COG2343@2|Bacteria,1GDMQ@1117|Cyanobacteria,1MMTV@1212|Prochloraceae 1117|Cyanobacteria S Domain of unknown function (DUF427) - - - - - - - - - - - - NTP_transf_9 k59_1340774_2 1211114.ALIP01000129_gene1365 7.36e-21 88.2 COG0239@1|root,COG0239@2|Bacteria,1MZNH@1224|Proteobacteria,1SWYN@1236|Gammaproteobacteria,1X8Q4@135614|Xanthomonadales 135614|Xanthomonadales D Important for reducing fluoride concentration in the cell, thus reducing its toxicity crcB - - ko:K06199 - - - - ko00000,ko02000 1.A.43.1,1.A.43.2,1.A.43.3 - - CRCB k59_1454189_1 1122137.AQXF01000003_gene1918 5.81e-124 377.0 COG1198@1|root,COG1198@2|Bacteria,1MUUZ@1224|Proteobacteria,2TQTQ@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA priA - - ko:K04066 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,Helicase_C k59_1403404_1 158500.BV97_01781 8.16e-94 294.0 COG4231@1|root,COG4231@2|Bacteria,1MUKS@1224|Proteobacteria,2TSHH@28211|Alphaproteobacteria,2K37Y@204457|Sphingomonadales 204457|Sphingomonadales C zinc finger - - 1.2.7.8 ko:K00179 - - - - br01601,ko00000,ko01000 - - - TPP_enzyme_C k59_437340_1 1535422.ND16A_3183 2.07e-50 182.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,2Q61E@267889|Colwelliaceae 1236|Gammaproteobacteria U Efflux pump membrane transporter bepG - - ko:K03296 - - - - ko00000 2.A.6.2 - - ACR_tran k59_725786_2 1234595.C725_2472 9.42e-11 62.8 COG2050@1|root,COG2050@2|Bacteria,1RBET@1224|Proteobacteria,2U5TM@28211|Alphaproteobacteria 28211|Alphaproteobacteria Q protein, possibly involved in aromatic compounds catabolism MA20_42425 - - - - - - - - - - - 4HBT k59_1682408_1 1415778.JQMM01000001_gene495 8.16e-62 192.0 COG0848@1|root,COG0848@2|Bacteria,1RI4M@1224|Proteobacteria,1T071@1236|Gammaproteobacteria,1J6HJ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria U Biopolymer transport protein ExbD/TolR - - - ko:K03559 - - - - ko00000,ko02000 1.A.30.2.1 - - ExbD k59_1791880_1 1410613.JNKF01000017_gene1871 1.83e-17 88.2 COG2197@1|root,COG2197@2|Bacteria,4PKZT@976|Bacteroidetes,2FP7J@200643|Bacteroidia 976|Bacteroidetes KT response regulator - - - - - - - - - - - - - k59_1574392_1 1122137.AQXF01000006_gene896 1.27e-110 340.0 COG1629@1|root,COG4771@2|Bacteria,1MWKN@1224|Proteobacteria,2U10R@28211|Alphaproteobacteria 28211|Alphaproteobacteria P receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_1516981_1 713586.KB900536_gene2191 3.58e-126 378.0 COG0661@1|root,COG0661@2|Bacteria,1MU1Z@1224|Proteobacteria,1RNQM@1236|Gammaproteobacteria,1WWEC@135613|Chromatiales 135613|Chromatiales S Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis ubiB - - ko:K03688 - - - - ko00000 - - - ABC1 k59_438452_1 102125.Xen7305DRAFT_00052920 2.4e-38 140.0 COG3576@1|root,COG3576@2|Bacteria,1G2UH@1117|Cyanobacteria,3VKSJ@52604|Pleurocapsales 1117|Cyanobacteria S Pfam:Pyridox_oxidase - - - ko:K07006 - - - - ko00000 - - - Putative_PNPOx k59_1116604_1 1229909.NSED_04685 3.44e-21 92.4 arCOG07810@1|root,arCOG07810@2157|Archaea,41T26@651137|Thaumarchaeota 651137|Thaumarchaeota T PFAM Adenylate and Guanylate cyclase catalytic domain - - 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 - - - Guanylate_cyc k59_835530_1 1123517.JOMR01000001_gene1183 1.69e-50 183.0 COG0471@1|root,COG0471@2|Bacteria,1MU0K@1224|Proteobacteria,1RMI1@1236|Gammaproteobacteria,462HB@72273|Thiotrichales 72273|Thiotrichales P Sodium:sulfate symporter transmembrane region - - - - - - - - - - - - CitMHS,TrkA_C k59_1739630_1 1207055.C100_18205 4.75e-97 298.0 COG0318@1|root,COG0318@2|Bacteria,1NR9B@1224|Proteobacteria,2UQN1@28211|Alphaproteobacteria,2K8PH@204457|Sphingomonadales 204457|Sphingomonadales IQ AMP-binding enzyme C-terminal domain - - - - - - - - - - - - AMP-binding,AMP-binding_C k59_47345_1 1423144.Gal_01296 3.13e-21 84.7 COG1278@1|root,COG1278@2|Bacteria,1N6Q5@1224|Proteobacteria,2UF6W@28211|Alphaproteobacteria,34FWK@302485|Phaeobacter 28211|Alphaproteobacteria K Ribonuclease B OB domain cspA4 - - ko:K03704 - - - - ko00000,ko03000 - - - CSD k59_47345_2 795666.MW7_2331 2.9e-36 124.0 COG0361@1|root,COG0361@2|Bacteria,1MZFU@1224|Proteobacteria,2VU4I@28216|Betaproteobacteria,1K8PA@119060|Burkholderiaceae 28216|Betaproteobacteria J One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex infA2 - - ko:K02518 - - - - ko00000,ko03012 - - - eIF-1a k59_1682442_1 391615.ABSJ01000059_gene2184 1.01e-125 376.0 COG0441@1|root,COG0441@2|Bacteria,1MUP2@1224|Proteobacteria,1RMYE@1236|Gammaproteobacteria,1J4XI@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) thrS GO:0000166,GO:0000900,GO:0002161,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004812,GO:0004829,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006417,GO:0006418,GO:0006435,GO:0006446,GO:0006450,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0016070,GO:0016787,GO:0016788,GO:0016874,GO:0016875,GO:0017076,GO:0017148,GO:0019222,GO:0019538,GO:0019752,GO:0030371,GO:0030554,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032553,GO:0032555,GO:0032559,GO:0034248,GO:0034249,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045182,GO:0045947,GO:0046483,GO:0046872,GO:0046914,GO:0048027,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0052689,GO:0060255,GO:0065007,GO:0065008,GO:0071704,GO:0080090,GO:0090079,GO:0090304,GO:0097159,GO:0097367,GO:0106074,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:2000112,GO:2000113 6.1.1.3 ko:K01868 ko00970,map00970 M00359,M00360 R03663 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iPC815.YPO2433,iSDY_1059.SDY_1814 HGTP_anticodon,TGS,tRNA-synt_2b,tRNA_SAD k59_549645_1 765914.ThisiDRAFT_0092 3.66e-14 70.5 COG0680@1|root,COG0680@2|Bacteria,1RGFM@1224|Proteobacteria,1S4XN@1236|Gammaproteobacteria,1WY9T@135613|Chromatiales 135613|Chromatiales C PFAM Peptidase A31, hydrogen uptake protein - - - ko:K03605 - - - - ko00000,ko01000,ko01002 - - - HycI k59_549645_2 2340.JV46_26670 1.55e-40 139.0 2DNYF@1|root,32ZSU@2|Bacteria,1N8ZB@1224|Proteobacteria,1S5ZH@1236|Gammaproteobacteria 1236|Gammaproteobacteria S PFAM HupH hydrogenase expression protein - - - ko:K03618 - - - - ko00000 - - - HupH_C k59_47350_2 754476.Q7A_767 1.7e-32 123.0 COG0362@1|root,COG0362@2|Bacteria,1MVV8@1224|Proteobacteria,1RM7P@1236|Gammaproteobacteria,45ZYI@72273|Thiotrichales 72273|Thiotrichales G Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH - - 1.1.1.343,1.1.1.44 ko:K00033 ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00480,map01100,map01110,map01120,map01130,map01200 M00004,M00006 R01528,R10221 RC00001,RC00539 ko00000,ko00001,ko00002,ko01000 - - - 6PGD,NAD_binding_2 k59_1285700_1 1214065.BAGV01000019_gene2462 1.8e-24 107.0 COG4776@1|root,COG4776@2|Bacteria,1P563@1224|Proteobacteria,1RP5G@1236|Gammaproteobacteria,283C4@191675|unclassified Enterobacteriaceae 1236|Gammaproteobacteria J Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction rnb GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004532,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008408,GO:0008859,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016796,GO:0016896,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0140098,GO:1901360,GO:1901361,GO:1901575 3.1.13.1 ko:K01147 - - - - ko00000,ko01000,ko03016 - - - OB_RNB,RNB,S1 k59_1627216_1 95619.PM1_0220610 2.16e-23 103.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,1RMH0@1236|Gammaproteobacteria 1236|Gammaproteobacteria NT chemotaxis, protein VPA0491 - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - 4HB_MCP_1,HAMP,HBM,MCPsignal k59_612690_1 1479237.JMLY01000001_gene3044 1.56e-45 155.0 COG0424@1|root,COG0424@2|Bacteria,1RH6H@1224|Proteobacteria,1S41D@1236|Gammaproteobacteria,467B9@72275|Alteromonadaceae 1236|Gammaproteobacteria D COG0424 Nucleotide-binding protein implicated in inhibition of septum formation yhdE GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0030145,GO:0036218,GO:0036221,GO:0042802,GO:0043167,GO:0043169,GO:0046872,GO:0046914,GO:0047429 - ko:K06287 - - - - ko00000 - - - Maf k59_612690_2 1121374.KB891579_gene1743 3.08e-13 68.9 COG1530@1|root,COG1530@2|Bacteria,1MV65@1224|Proteobacteria,1RMIW@1236|Gammaproteobacteria 1236|Gammaproteobacteria J Involved in the processing of the 5'-end of 16S rRNA rng GO:0003674,GO:0003824,GO:0004518,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005856,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008996,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016787,GO:0016788,GO:0022613,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0140098,GO:1901360 - ko:K08301 - - - - ko00000,ko01000,ko03009,ko03019 - - - RNase_E_G,S1 k59_549659_1 504487.JCM19302_3746 3.02e-105 320.0 COG3203@1|root,COG3203@2|Bacteria,4PKBJ@976|Bacteroidetes,1HYG6@117743|Flavobacteriia 976|Bacteroidetes M CarboxypepD_reg-like domain - - - - - - - - - - - - CarbopepD_reg_2 k59_664903_1 391587.KAOT1_21312 4.66e-35 131.0 COG3177@1|root,COG3177@2|Bacteria,4NR8T@976|Bacteroidetes,1I96X@117743|Flavobacteriia 976|Bacteroidetes S Domain of unknown function (DUF4157) - - - - - - - - - - - - DUF4157 k59_664907_1 864073.HFRIS_019748 1.22e-56 192.0 COG4536@1|root,COG4536@2|Bacteria,1NZ99@1224|Proteobacteria,2WGFR@28216|Betaproteobacteria,473XN@75682|Oxalobacteraceae 28216|Betaproteobacteria P Transporter associated domain corB - - - - - - - - - - - CBS,CorC_HlyC,DUF21 k59_393132_1 1550073.JROH01000025_gene1052 4.43e-43 145.0 COG1956@1|root,COG1956@2|Bacteria,1RDBM@1224|Proteobacteria,2U595@28211|Alphaproteobacteria,2K4NG@204457|Sphingomonadales 204457|Sphingomonadales T GAF domain-containing protein - - 1.8.4.14 ko:K08968 ko00270,map00270 - R02025 RC00639 ko00000,ko00001,ko01000 - - - GAF_2 k59_393132_2 1399774.JDWH01000001_gene2865 6.1e-27 103.0 COG0231@1|root,COG0231@2|Bacteria,1MW2J@1224|Proteobacteria,1RPW7@1236|Gammaproteobacteria,3X0XN@547|Enterobacter 1236|Gammaproteobacteria J Involved in peptide bond synthesis. Alleviates ribosome stalling that occurs when 3 or more consecutive Pro residues or the sequence PPG is present in a protein, possibly by augmenting the peptidyl transferase activity of the ribosome. Modification of efp GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006414,GO:0006417,GO:0006448,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0017148,GO:0019222,GO:0019538,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0034248,GO:0034249,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0045900,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0071704,GO:0072344,GO:0080090,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:2000112,GO:2000113,GO:2001124,GO:2001125 - ko:K02356 - - - - ko00000,ko03012 - - - EFP,EFP_N,Elong-fact-P_C k59_618242_1 330214.NIDE3255 1.24e-109 344.0 COG0243@1|root,COG0243@2|Bacteria 2|Bacteria C molybdopterin cofactor binding ddhA GO:0005575,GO:0005623,GO:0042597,GO:0044464 1.17.99.2,1.7.5.1,1.8.2.4 ko:K00370,ko:K10700,ko:K16964,ko:K17050 ko00642,ko00910,ko00920,ko01100,ko01120,ko01220,ko02020,map00642,map00910,map00920,map01100,map01120,map01220,map02020 M00529,M00530,M00804 R00798,R01106,R05745,R09497,R09500 RC00275,RC02555,RC02812 ko00000,ko00001,ko00002,ko01000,ko02000 5.A.3.1,5.A.3.8,5.A.3.9 - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding,TAT_signal k59_841124_3 393595.ABO_1841 1.1e-06 48.9 COG0290@1|root,COG0290@2|Bacteria,1RDD2@1224|Proteobacteria,1S4E6@1236|Gammaproteobacteria,1XJSV@135619|Oceanospirillales 135619|Oceanospirillales J IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins infC - - ko:K02520 - - - - ko00000,ko03012,ko03029 - - - IF3_C,IF3_N k59_220372_1 314262.MED193_04796 2.39e-98 291.0 COG1126@1|root,COG1126@2|Bacteria,1MU9Q@1224|Proteobacteria,2TQX2@28211|Alphaproteobacteria,2P2AS@2433|Roseobacter 28211|Alphaproteobacteria E COG1126 ABC-type polar amino acid transport system, ATPase component glnQ - 3.6.3.21 ko:K02028 - M00236 - - ko00000,ko00002,ko01000,ko02000 3.A.1.3 - - ABC_tran k59_555146_1 882378.RBRH_02951 2.19e-79 241.0 COG0655@1|root,COG0655@2|Bacteria,1MW7N@1224|Proteobacteria,2VJMC@28216|Betaproteobacteria,1K096@119060|Burkholderiaceae 28216|Betaproteobacteria S Belongs to the WrbA family wrbA - 1.6.5.2 ko:K03809 ko00130,ko01110,map00130,map01110 - R02964,R03643,R03816 RC00819 ko00000,ko00001,ko01000 - - - FMN_red k59_555146_2 1294273.roselon_03614 2.55e-08 52.4 COG1393@1|root,COG1393@2|Bacteria 2|Bacteria P arsenate reductase (glutaredoxin) activity arsC GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 1.20.4.1 ko:K00537 - - - - ko00000,ko01000 - - - ArsC k59_1797241_1 1121365.AQXB01000007_gene287 6.35e-16 75.1 COG0020@1|root,COG0020@2|Bacteria,2GJCP@201174|Actinobacteria,22JME@1653|Corynebacteriaceae 201174|Actinobacteria H Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids uppS1 GO:0000287,GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006066,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016020,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0030145,GO:0033850,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0046872,GO:0046914,GO:0071704,GO:0071944,GO:1901576,GO:1901615,GO:1901617 2.5.1.31,2.5.1.68 ko:K00806,ko:K12503 ko00900,ko01110,map00900,map01110 - R06447,R08528 RC00279,RC02839 ko00000,ko00001,ko01000,ko01006 - - - Prenyltransf k59_1797241_2 1380370.JIBA01000012_gene3591 2.29e-28 106.0 COG3070@1|root,COG3070@2|Bacteria,2IKPV@201174|Actinobacteria,4FI2S@85021|Intrasporangiaceae 201174|Actinobacteria K TfoX N-terminal domain - - - - - - - - - - - - TfoX_N k59_1522350_1 717785.HYPMC_0686 2.62e-18 88.2 COG0523@1|root,COG0523@2|Bacteria,1MVZV@1224|Proteobacteria,2TQWN@28211|Alphaproteobacteria,3N674@45401|Hyphomicrobiaceae 28211|Alphaproteobacteria S cobalamin biosynthesis protein CobW cobW - - ko:K02234 - - - - ko00000,ko00001 - - - CobW_C,cobW k59_952218_1 1122137.AQXF01000002_gene361 6.83e-88 275.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2TQS3@28211|Alphaproteobacteria 28211|Alphaproteobacteria T Diguanylate cyclase MA20_18100 - 3.1.4.52 ko:K13245 ko04112,map04112 - R08991 RC00296 ko00000,ko00001,ko01000 - - - 7TMR-DISMED2,7TMR-DISM_7TM,EAL,GGDEF,PAS_3 k59_393162_1 1415780.JPOG01000001_gene2845 4.02e-23 96.3 COG0607@1|root,COG0607@2|Bacteria,1MZ83@1224|Proteobacteria,1S8ZI@1236|Gammaproteobacteria,1X737@135614|Xanthomonadales 135614|Xanthomonadales P Rhodanese-related sulfurtransferase - - - - - - - - - - - - Rhodanese k59_1579993_1 118168.MC7420_5481 3.07e-40 143.0 COG2319@1|root,COG2319@2|Bacteria 2|Bacteria S anaphase-promoting complex binding - - - - - - - - - - - - Peptidase_C14,SIR2_2,TIR_2,WD40 k59_336100_1 1120792.JAFV01000001_gene3588 2.54e-62 207.0 COG2317@1|root,COG2317@2|Bacteria,1MW7T@1224|Proteobacteria,2TSMY@28211|Alphaproteobacteria,36ZJQ@31993|Methylocystaceae 28211|Alphaproteobacteria E Carboxypeptidase Taq (M32) metallopeptidase - - 3.4.17.19 ko:K01299 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M32 k59_781697_1 1122137.AQXF01000007_gene3515 6.79e-192 559.0 COG0567@1|root,COG0567@2|Bacteria,1MVBF@1224|Proteobacteria,2TRBQ@28211|Alphaproteobacteria 28211|Alphaproteobacteria C COG0567 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes sucA - 1.2.4.2 ko:K00164 ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00032 R00621,R01933,R01940,R03316,R08549 RC00004,RC00027,RC00627,RC02743,RC02833,RC02883 br01601,ko00000,ko00001,ko00002,ko01000 - - - 2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr k59_1291371_1 1304877.KI519400_gene1513 7.5e-81 252.0 COG3385@1|root,COG3385@2|Bacteria,1PMXF@1224|Proteobacteria,2U1D5@28211|Alphaproteobacteria,3JXTT@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria L Transposase DDE domain - - - - - - - - - - - - DDE_Tnp_1,DUF4372 k59_1007751_2 204669.Acid345_4096 5.82e-05 49.7 COG3735@1|root,COG3735@2|Bacteria,3Y8EE@57723|Acidobacteria,2JNKZ@204432|Acidobacteriia 204432|Acidobacteriia S TraB family - - - ko:K09973 - - - - ko00000 - - - TraB k59_1121962_1 991905.SL003B_4259 7.44e-76 245.0 COG0659@1|root,COG0659@2|Bacteria,1MWDF@1224|Proteobacteria,2TT0G@28211|Alphaproteobacteria,4BRTG@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria U Sulfate permease family - - - ko:K03321 - - - - ko00000,ko02000 2.A.53.3 - - STAS,Sulfate_transp k59_1069022_2 448385.sce2670 5.31e-14 80.5 2DQ41@1|root,334MP@2|Bacteria,1QWJG@1224|Proteobacteria 1224|Proteobacteria S Kazal type serine protease inhibitors - - - - - - - - - - - - Kazal_1 k59_1744871_1 795666.MW7_2906 3.17e-49 175.0 COG0243@1|root,COG0243@2|Bacteria,1NR6J@1224|Proteobacteria,2VJQ4@28216|Betaproteobacteria,1K5E8@119060|Burkholderiaceae 28216|Betaproteobacteria C Molydopterin dinucleotide binding domain - - - - - - - - - - - - FAD_binding_6,Fer2,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NAD_binding_1 k59_952236_1 483219.LILAB_17770 9.9e-137 402.0 COG2805@1|root,COG2805@2|Bacteria,1MU3J@1224|Proteobacteria,42M7F@68525|delta/epsilon subdivisions,2WJ28@28221|Deltaproteobacteria,2YWA0@29|Myxococcales 28221|Deltaproteobacteria NU Type II/IV secretion system protein pilT-1 - - ko:K02669 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE k59_952236_2 644282.Deba_1140 1.13e-97 310.0 COG0013@1|root,COG0013@2|Bacteria,1MU9A@1224|Proteobacteria,42M70@68525|delta/epsilon subdivisions,2WJA8@28221|Deltaproteobacteria 28221|Deltaproteobacteria J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain alaS GO:0003674,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016597,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.7 ko:K01872 ko00970,map00970 M00359,M00360 R03038 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DHHA1,tRNA-synt_2c,tRNA_SAD k59_1121966_1 1449049.JONW01000009_gene4317 2.31e-12 64.7 2DSPA@1|root,33GWY@2|Bacteria,1NNRJ@1224|Proteobacteria,2VGIS@28211|Alphaproteobacteria,2KJV2@204458|Caulobacterales 204458|Caulobacterales - - - - - - - - - - - - - - - k59_1121966_2 316274.Haur_0038 2.39e-09 59.7 COG1013@1|root,COG1013@2|Bacteria,2G679@200795|Chloroflexi,374ZH@32061|Chloroflexia 32061|Chloroflexia C PFAM thiamine pyrophosphate protein domain protein TPP-binding - - 1.2.7.11,1.2.7.3 ko:K00175 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - PFO_beta_C,TPP_enzyme_C k59_163254_1 330214.NIDE1319 1.94e-10 57.0 COG0255@1|root,COG0255@2|Bacteria 2|Bacteria J Belongs to the universal ribosomal protein uL29 family rpmC GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02904 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L29 k59_163254_2 330214.NIDE1318 1.63e-85 253.0 COG0197@1|root,COG0197@2|Bacteria,3J0H7@40117|Nitrospirae 40117|Nitrospirae J Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs rplP GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0097159,GO:1901363,GO:1990904 - ko:K02878 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L16 k59_163254_3 330214.NIDE1317 3.48e-10 58.9 COG0092@1|root,COG0092@2|Bacteria,3J0AP@40117|Nitrospirae 40117|Nitrospirae J Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation rpsC GO:0002181,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02982 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - KH_2,Ribosomal_S3_C k59_1007761_1 1229909.NSED_06130 4.81e-112 338.0 COG1028@1|root,arCOG01259@2157|Archaea,41S7V@651137|Thaumarchaeota 651137|Thaumarchaeota I Enoyl-(Acyl carrier protein) reductase - - - - - - - - - - - - adh_short k59_670323_1 1231190.NA8A_22481 1.68e-94 286.0 COG1638@1|root,COG1638@2|Bacteria,1PFSU@1224|Proteobacteria,2TVA1@28211|Alphaproteobacteria,43MUT@69277|Phyllobacteriaceae 28211|Alphaproteobacteria G Bacterial extracellular solute-binding protein, family 7 - - - - - - - - - - - - DctP k59_841200_1 316407.85676687 9.86e-132 379.0 COG0429@1|root,COG0429@2|Bacteria,1MWV1@1224|Proteobacteria,1RN39@1236|Gammaproteobacteria,3XMVG@561|Escherichia 1236|Gammaproteobacteria S poly(3-hydroxybutyrate) depolymerase activity yheT GO:0003674,GO:0003824,GO:0006629,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016788,GO:0044237,GO:0044238,GO:0044255,GO:0050526,GO:0052689,GO:0071704 - ko:K07019 - - - - ko00000 - - - Abhydrolase_1 k59_841200_2 316407.85676688 8.58e-16 75.9 COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,1RPES@1236|Gammaproteobacteria,3XNB3@561|Escherichia 1236|Gammaproteobacteria S ABC transporter, ATP-binding protein yheS GO:0000166,GO:0003674,GO:0005488,GO:0005524,GO:0008144,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - ko:K06158 - - - - ko00000,ko03012 - - - ABC_tran,ABC_tran_CTD,ABC_tran_Xtn k59_901431_1 1114964.L485_20075 4.61e-12 65.5 COG0783@1|root,COG0783@2|Bacteria,1RAC5@1224|Proteobacteria,2U5Q5@28211|Alphaproteobacteria,2K3P2@204457|Sphingomonadales 204457|Sphingomonadales P Belongs to the Dps family - - - ko:K04047 - - - - ko00000,ko03036 - - - Ferritin k59_901431_3 247490.KSU1_C0123 1.16e-06 48.9 COG0151@1|root,COG0151@2|Bacteria 2|Bacteria F phosphoribosylamine-glycine ligase activity purD - 6.3.4.13,6.3.5.5 ko:K01945,ko:K01955 ko00230,ko00240,ko00250,ko01100,ko01110,ko01130,map00230,map00240,map00250,map01100,map01110,map01130 M00048,M00051 R00256,R00575,R01395,R04144,R10948,R10949 RC00002,RC00010,RC00043,RC00090,RC00166,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - - ATP-grasp_3,GARS_A,GARS_C,GARS_N k59_1688780_1 1203605.HMPREF1531_01314 1.95e-09 62.8 COG1231@1|root,COG1231@2|Bacteria,2GK23@201174|Actinobacteria,4DP12@85009|Propionibacteriales 201174|Actinobacteria E amine oxidase - - 1.4.3.4 ko:K00274 ko00260,ko00330,ko00340,ko00350,ko00360,ko00380,ko00950,ko00982,ko01100,ko01110,ko04726,ko04728,ko05030,ko05031,ko05034,map00260,map00330,map00340,map00350,map00360,map00380,map00950,map00982,map01100,map01110,map04726,map04728,map05030,map05031,map05034 M00135 R02173,R02382,R02529,R02532,R02613,R02908,R02919,R04025,R04300,R04674,R04890,R04893,R04894,R04907,R04908,R08346,R08347,R08348,R11354 RC00062,RC00160,RC00225,RC00676,RC00807,RC00808,RC01808,RC02226,RC02713 ko00000,ko00001,ko00002,ko01000 - - - Amino_oxidase k59_393902_1 203122.Sde_0798 7.13e-50 182.0 COG0747@1|root,COG2356@1|root,COG2911@1|root,COG2982@1|root,COG3210@1|root,COG3506@1|root,COG3637@1|root,COG0747@2|Bacteria,COG2356@2|Bacteria,COG2911@2|Bacteria,COG2982@2|Bacteria,COG3210@2|Bacteria,COG3506@2|Bacteria,COG3637@2|Bacteria,1P8N9@1224|Proteobacteria,1SCTK@1236|Gammaproteobacteria,46D2E@72275|Alteromonadaceae 1236|Gammaproteobacteria M Cadherin repeats. - - - - - - - - - - - - Cadherin,DUF4347,DUF5122,He_PIG,OmpA_membrane k59_732199_1 1453501.JELR01000001_gene2613 6.82e-125 372.0 COG3067@1|root,COG3067@2|Bacteria,1MV0F@1224|Proteobacteria,1RPE3@1236|Gammaproteobacteria,464PD@72275|Alteromonadaceae 1236|Gammaproteobacteria P Na( ) H( ) antiporter that extrudes sodium in exchange for external protons nhaB GO:0003674,GO:0005215,GO:0005451,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006814,GO:0006873,GO:0006885,GO:0008150,GO:0008324,GO:0009987,GO:0010035,GO:0010038,GO:0010226,GO:0015075,GO:0015077,GO:0015078,GO:0015081,GO:0015291,GO:0015297,GO:0015298,GO:0015299,GO:0015318,GO:0015385,GO:0015491,GO:0015672,GO:0016020,GO:0019725,GO:0022804,GO:0022857,GO:0022890,GO:0030001,GO:0030003,GO:0030004,GO:0030641,GO:0034220,GO:0035725,GO:0042221,GO:0042592,GO:0044464,GO:0045851,GO:0046873,GO:0048878,GO:0050801,GO:0050896,GO:0051179,GO:0051234,GO:0051452,GO:0051453,GO:0055067,GO:0055080,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:0098771,GO:0099516,GO:1902600 - ko:K03314 - - - - ko00000,ko02000 2.A.34.1 - iECP_1309.ECP_1229,iLF82_1304.LF82_1485,iNRG857_1313.NRG857_06055,iUTI89_1310.UTI89_C1372 NhaB k59_1461860_1 670292.JH26_05275 7.43e-16 80.5 COG1216@1|root,COG1216@2|Bacteria,1N72Z@1224|Proteobacteria,2U5XZ@28211|Alphaproteobacteria,1JTSM@119045|Methylobacteriaceae 28211|Alphaproteobacteria S Glycosyltransferase like family 2 - - - ko:K16555 - - - - ko00000,ko01000,ko01003 - GT2 - Glycos_transf_2 k59_902204_1 1449076.JOOE01000002_gene1041 1.35e-110 333.0 COG0438@1|root,COG0438@2|Bacteria,1MUB7@1224|Proteobacteria,2TQQ0@28211|Alphaproteobacteria,2K14F@204457|Sphingomonadales 204457|Sphingomonadales M Glycosyl transferase - - - - - - - - - - - - Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1 k59_109640_1 1229909.NSED_01220 1.48e-24 104.0 arCOG08785@1|root,arCOG08785@2157|Archaea,41SVD@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - ko:K03646 - - - - ko00000,ko02000 2.C.1.2 - - - k59_619127_1 1479239.JQMU01000001_gene1158 6.35e-49 173.0 COG2199@1|root,COG3706@2|Bacteria,1MW39@1224|Proteobacteria,2U25F@28211|Alphaproteobacteria,2KDVH@204457|Sphingomonadales 204457|Sphingomonadales T 7TM diverse intracellular signalling - - - - - - - - - - - - 7TMR-DISM_7TM,GGDEF k59_1580730_1 1336233.JAEH01000040_gene4306 2.68e-119 361.0 COG0793@1|root,COG0793@2|Bacteria,1MUA3@1224|Proteobacteria,1RR5H@1236|Gammaproteobacteria,2Q9HB@267890|Shewanellaceae 1236|Gammaproteobacteria M Peptidase family S41 - - - - - - - - - - - - Peptidase_S41 k59_953057_1 1267535.KB906767_gene2038 9.41e-41 148.0 COG2801@1|root,COG2801@2|Bacteria,3Y821@57723|Acidobacteria 57723|Acidobacteria L Integrase core domain - - - - - - - - - - - - rve_3 k59_953057_2 1550073.JROH01000021_gene181 1e-26 107.0 COG0247@1|root,COG0247@2|Bacteria,1MWTK@1224|Proteobacteria,2TR9H@28211|Alphaproteobacteria,2K3M8@204457|Sphingomonadales 204457|Sphingomonadales C Cysteine-rich domain - - - ko:K11473,ko:K18928 ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130 - R00475 RC00042 ko00000,ko00001 - - - CCG,Fer4_7 k59_1122811_1 518766.Rmar_0304 6.47e-20 90.1 COG1600@1|root,COG1600@2|Bacteria,4NFCJ@976|Bacteroidetes,1FJQT@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes C 4Fe-4S double cluster binding domain queG - 1.17.99.6 ko:K18979 - - - - ko00000,ko01000,ko03016 - - - DUF1730,Fer4_16 k59_221149_2 1123053.AUDG01000071_gene1495 1.02e-58 208.0 COG3590@1|root,COG3590@2|Bacteria,1MVNQ@1224|Proteobacteria,1RNNA@1236|Gammaproteobacteria 1236|Gammaproteobacteria O peptidase, M13 pepO - 3.4.24.71 ko:K01415,ko:K07386 - - - - ko00000,ko01000,ko01002,ko04147 - - - Peptidase_M13,Peptidase_M13_N k59_500067_2 1121374.KB891586_gene2543 5.99e-65 204.0 COG2080@1|root,COG2080@2|Bacteria,1RD8C@1224|Proteobacteria,1S3RP@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Aerobic-type carbon monoxide dehydrogenase small subunit CoxS - - - - - - - - - - - - Fer2,Fer2_2 k59_902237_1 67267.JNXT01000041_gene5576 9.98e-09 62.0 COG5555@1|root,COG5555@2|Bacteria,2GKZ9@201174|Actinobacteria 201174|Actinobacteria N Integrin alpha (beta-propellor repeats). - - - - - - - - - - - - FG-GAP,VCBS k59_164048_1 1089552.KI911559_gene3117 3.06e-12 66.6 COG2256@1|root,COG2256@2|Bacteria,1MUVS@1224|Proteobacteria,2TQVF@28211|Alphaproteobacteria,2JQG6@204441|Rhodospirillales 204441|Rhodospirillales L COG2256 ATPase related to the helicase subunit of the Holliday junction resolvase rarA - - ko:K07478 - - - - ko00000 - - - AAA,AAA_assoc_2,MgsA_C,RuvB_N k59_164048_2 1122137.AQXF01000006_gene941 2.56e-95 287.0 2CF7S@1|root,32S1E@2|Bacteria,1R918@1224|Proteobacteria,2UBK2@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_500084_1 1347342.BN863_25220 8.36e-20 87.8 COG0399@1|root,COG0399@2|Bacteria,4NEBI@976|Bacteroidetes,1HWJK@117743|Flavobacteriia 976|Bacteroidetes E Belongs to the DegT DnrJ EryC1 family - - - - - - - - - - - - DegT_DnrJ_EryC1 k59_500084_2 1137281.D778_00228 4.04e-112 336.0 COG2244@1|root,COG2244@2|Bacteria,4NI85@976|Bacteroidetes,1HXZ7@117743|Flavobacteriia 976|Bacteroidetes S Membrane protein involved in the export of O-antigen and teichoic acid wzxE - - ko:K03328 - - - - ko00000 2.A.66.2 - - Polysacc_synt,Polysacc_synt_3,Polysacc_synt_C k59_1580771_1 1049564.TevJSym_be00220 1.04e-07 52.8 COG2391@1|root,COG2391@2|Bacteria,1MXSE@1224|Proteobacteria,1RSMW@1236|Gammaproteobacteria,1JB8I@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Sulphur transport - - - ko:K07112 - - - - ko00000 - - - Sulf_transp k59_1348224_1 1123508.JH636439_gene913 1.86e-78 253.0 COG0128@1|root,COG0128@2|Bacteria,2IXRF@203682|Planctomycetes 203682|Planctomycetes E Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate aroA - 2.5.1.19 ko:K00800 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R03460 RC00350 ko00000,ko00001,ko00002,ko01000 - - - EPSP_synthase k59_1348224_2 1408428.JNJP01000105_gene2661 4.34e-59 199.0 COG0075@1|root,COG0075@2|Bacteria,1MWHJ@1224|Proteobacteria,42MBH@68525|delta/epsilon subdivisions,2WJQV@28221|Deltaproteobacteria,2M94P@213115|Desulfovibrionales 28221|Deltaproteobacteria E PFAM aminotransferase class V - - - - - - - - - - - - Aminotran_5 k59_1348224_3 1094980.Mpsy_2915 3.88e-11 67.4 COG0075@1|root,arCOG00082@2157|Archaea,2XTWU@28890|Euryarchaeota,2N9EM@224756|Methanomicrobia 224756|Methanomicrobia E PFAM aminotransferase class V - - - - - - - - - - - - Aminotran_5 k59_1348224_4 1125863.JAFN01000001_gene1833 1.36e-180 525.0 COG0111@1|root,COG0111@2|Bacteria,1MU5Z@1224|Proteobacteria,42M1C@68525|delta/epsilon subdivisions,2WIZQ@28221|Deltaproteobacteria 28221|Deltaproteobacteria C D-isomer specific 2-hydroxyacid dehydrogenase - - 1.1.1.399,1.1.1.95 ko:K00058 ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230 M00020 R01513 RC00031 ko00000,ko00001,ko00002,ko01000,ko04147 - - - 2-Hacid_dh,2-Hacid_dh_C,ACT k59_902260_1 1229909.NSED_02670 1.12e-82 251.0 COG2102@1|root,arCOG00035@2157|Archaea,41SHD@651137|Thaumarchaeota 651137|Thaumarchaeota S Diphthamide synthase - - 6.3.1.14 ko:K06927 - - R03613 RC00358 ko00000,ko01000,ko03012 - - - Diphthami_syn_2 k59_444899_2 436308.Nmar_1796 1.22e-65 201.0 arCOG08806@1|root,arCOG08806@2157|Archaea,41SUU@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1181571_1 1121921.KB898711_gene1969 8.75e-15 72.8 COG0135@1|root,COG0135@2|Bacteria,1RA87@1224|Proteobacteria,1S41P@1236|Gammaproteobacteria,2PNGI@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria E N-(5'phosphoribosyl)anthranilate (PRA) isomerase trpF - 5.3.1.24 ko:K01817 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R03509 RC00945 ko00000,ko00001,ko00002,ko01000 - - - PRAI k59_1181571_2 472759.Nhal_1969 5.75e-62 202.0 COG0133@1|root,COG0133@2|Bacteria,1MUS8@1224|Proteobacteria,1RP4D@1236|Gammaproteobacteria,1WW9F@135613|Chromatiales 135613|Chromatiales E The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine trpB - 4.2.1.20 ko:K01696 ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230 M00023 R00674,R02340,R02722 RC00209,RC00210,RC00700,RC00701,RC02868 ko00000,ko00001,ko00002,ko01000 - - - PALP k59_782568_1 1288494.EBAPG3_11070 3.2e-65 207.0 COG1075@1|root,COG1075@2|Bacteria,1N2W0@1224|Proteobacteria,2VU6X@28216|Betaproteobacteria 28216|Betaproteobacteria S Alpha/beta hydrolase family - - - - - - - - - - - - Hydrolase_4 k59_619164_1 1045855.DSC_13730 1.79e-73 234.0 COG0473@1|root,COG0473@2|Bacteria,1MUH4@1224|Proteobacteria,1RMZQ@1236|Gammaproteobacteria,1X4UN@135614|Xanthomonadales 135614|Xanthomonadales CE Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate leuB GO:0003674,GO:0003824,GO:0003862,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.85 ko:K00052 ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230 M00432,M00535 R00994,R04426,R10052 RC00084,RC00417,RC03036 br01601,ko00000,ko00001,ko00002,ko01000 - - - Iso_dh k59_109706_1 316407.85676283 1.97e-63 198.0 COG2186@1|root,COG2186@2|Bacteria,1MV83@1224|Proteobacteria,1RR9F@1236|Gammaproteobacteria,3XM43@561|Escherichia 1236|Gammaproteobacteria K DNA-binding transcription factor activity yieP GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - - - - - - - - - - FCD,GntR k59_341745_1 56780.SYN_02346 1.19e-57 188.0 COG0412@1|root,COG0412@2|Bacteria,1MW7S@1224|Proteobacteria,42Q9U@68525|delta/epsilon subdivisions,2X5CC@28221|Deltaproteobacteria 28221|Deltaproteobacteria Q BAAT / Acyl-CoA thioester hydrolase C terminal - - - - - - - - - - - - DLH k59_228446_1 136273.GY22_02210 4.54e-17 78.6 COG4635@1|root,COG4635@2|Bacteria,2IQCQ@201174|Actinobacteria,1W9SR@1268|Micrococcaceae 201174|Actinobacteria CH Flavodoxin domain - - 1.3.5.3 ko:K00230 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R09489 RC00885 ko00000,ko00001,ko00002,ko01000 - - - Flavodoxin_5 k59_115899_1 1229909.NSED_09485 9.25e-23 92.8 arCOG08811@1|root,arCOG08811@2157|Archaea,41T85@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_115899_2 1229909.NSED_09490 9.44e-36 132.0 COG0174@1|root,arCOG01909@2157|Archaea,41SD6@651137|Thaumarchaeota 651137|Thaumarchaeota E TIGRFAM glutamine synthetase, type I - - 6.3.1.2 ko:K01915 ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 - R00253 RC00010,RC02798 ko00000,ko00001,ko01000,ko04147 - - - Gln-synt_C,Gln-synt_N k59_115910_1 575589.HMPREF0018_00670 2.32e-89 284.0 COG3119@1|root,COG3119@2|Bacteria,1MV92@1224|Proteobacteria,1RPDE@1236|Gammaproteobacteria,3NJ0S@468|Moraxellaceae 1236|Gammaproteobacteria P Sulfatase atsA - 3.1.6.1 ko:K01130 ko00140,ko00600,map00140,map00600 - R03980,R04856 RC00128,RC00231 ko00000,ko00001,ko01000 - - - Sulfatase,Sulfatase_C k59_906279_1 485913.Krac_1213 2.37e-139 409.0 COG1239@1|root,COG1239@2|Bacteria 2|Bacteria H Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX chlI - 6.6.1.1 ko:K03405 ko00860,ko01100,ko01110,map00860,map01100,map01110 - R03877 RC01012 ko00000,ko00001,ko01000 - - iNJ661.Rv0958 Mg_chelatase,Sigma54_activat k59_1584309_1 316067.Geob_0215 3.81e-59 204.0 COG1148@1|root,COG1148@2|Bacteria,1QUM4@1224|Proteobacteria,42MPP@68525|delta/epsilon subdivisions,2WJ3U@28221|Deltaproteobacteria,43THI@69541|Desulfuromonadales 28221|Deltaproteobacteria C FAD dependent oxidoreductase bamE - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 ko:K03388 ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200 M00356,M00357,M00563,M00567 R04540,R11928,R11931,R11943,R11944 RC00011 ko00000,ko00001,ko00002,ko01000 - - - Fer4,Fer4_7,Pyr_redox_2 k59_1584309_2 56780.SYN_00625 2.62e-32 119.0 COG1908@1|root,COG2768@1|root,COG1908@2|Bacteria,COG2768@2|Bacteria,1R93S@1224|Proteobacteria,42QKE@68525|delta/epsilon subdivisions,2WMF5@28221|Deltaproteobacteria,2MR7Y@213462|Syntrophobacterales 28221|Deltaproteobacteria C Methyl-viologen-reducing hydrogenase, delta subunit - - - - - - - - - - - - Fer4,FlpD k59_1471493_1 504472.Slin_1835 3.59e-27 115.0 COG0612@1|root,COG0612@2|Bacteria,4NEDZ@976|Bacteroidetes,47K02@768503|Cytophagia 976|Bacteroidetes S Belongs to the peptidase M16 family - - - ko:K07263 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M16,Peptidase_M16_C k59_737427_1 452637.Oter_2221 3.87e-52 182.0 COG0477@1|root,COG0477@2|Bacteria,46U4Q@74201|Verrucomicrobia,3K8SC@414999|Opitutae 414999|Opitutae U major facilitator superfamily - - - ko:K03446 - M00701 - - ko00000,ko00002,ko02000 2.A.1.3 - - MFS_1 k59_172334_1 240016.ABIZ01000001_gene4737 1.42e-51 171.0 COG3128@1|root,COG3128@2|Bacteria,46TZ2@74201|Verrucomicrobia,2IV45@203494|Verrucomicrobiae 203494|Verrucomicrobiae S Prolyl 4-hydroxylase alpha subunit homologues. - - - - - - - - - - - - 2OG-FeII_Oxy_3 k59_1132470_1 224325.AF_0135 1.37e-05 48.9 COG1545@1|root,arCOG01288@2157|Archaea 2157|Archaea S Rubredoxin-like zinc ribbon domain (DUF35_N) - - - ko:K07068 - - - - ko00000 - - - DUF35_N,OB_aCoA_assoc k59_1132470_2 439235.Dalk_4049 1.75e-14 70.9 COG1545@1|root,COG1545@2|Bacteria,1NV6I@1224|Proteobacteria,42ZHC@68525|delta/epsilon subdivisions,2WUSN@28221|Deltaproteobacteria 28221|Deltaproteobacteria S PFAM Rubredoxin-like zinc ribbon domain (DUF35_N) - - - ko:K07068 - - - - ko00000 - - - DUF35_N,OB_aCoA_assoc k59_285321_1 313606.M23134_05036 8.2e-42 154.0 COG1283@1|root,COG1283@2|Bacteria,4NHMY@976|Bacteroidetes,47NEB@768503|Cytophagia 976|Bacteroidetes P Na+/Pi-cotransporter - - - ko:K03324 - - - - ko00000,ko02000 2.A.58.2 - - Na_Pi_cotrans k59_172343_1 436308.Nmar_0987 9.04e-48 161.0 COG1405@1|root,arCOG01981@2157|Archaea,41SYU@651137|Thaumarchaeota 651137|Thaumarchaeota K Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB) - - - ko:K03124 ko03022,ko05169,ko05203,map03022,map05169,map05203 - - - ko00000,ko00001,ko03021 - - - TFIIB,TF_Zn_Ribbon k59_680451_1 631362.Thi970DRAFT_03295 1.03e-50 174.0 COG2801@1|root,COG2801@2|Bacteria,1R6TH@1224|Proteobacteria,1RRWS@1236|Gammaproteobacteria,1X2I8@135613|Chromatiales 135613|Chromatiales L Mu transposase, C-terminal - - - - - - - - - - - - HTH_32,Mu-transpos_C,rve k59_115927_1 1123393.KB891316_gene1266 3.72e-08 56.2 COG2143@1|root,COG2143@2|Bacteria,1QDKY@1224|Proteobacteria,2WDTN@28216|Betaproteobacteria,1KSHJ@119069|Hydrogenophilales 119069|Hydrogenophilales O Thioredoxin-like domain - - - - - - - - - - - - Thioredoxin_2 k59_1019815_1 1122194.AUHU01000010_gene3143 1.14e-05 47.0 COG0457@1|root,COG0457@2|Bacteria,1Q3TC@1224|Proteobacteria,1RRC8@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Domain of unknown function (DUF5107) yphG - - - - - - - - - - - DUF5107,TPR_16,TPR_8 k59_1019815_2 595460.RRSWK_01652 3.05e-74 235.0 COG0477@1|root,COG2814@2|Bacteria 2|Bacteria EGP Major facilitator Superfamily - - - ko:K03444 - - - - ko00000,ko02000 2.A.1.1 - - Sugar_tr k59_1302971_1 436308.Nmar_1698 1.74e-196 555.0 COG0004@1|root,arCOG04397@2157|Archaea,41SY0@651137|Thaumarchaeota 651137|Thaumarchaeota P Ammonium Transporter - - - ko:K03320 - - - - ko00000,ko02000 1.A.11 - - Ammonium_transp k59_1302971_2 436308.Nmar_1697 1.86e-11 62.8 COG2897@1|root,arCOG02019@2157|Archaea,41SXR@651137|Thaumarchaeota 651137|Thaumarchaeota P Rhodanese Homology Domain - - 2.8.1.1,2.8.1.2 ko:K01011 ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122 - R01931,R03105,R03106 RC00214 ko00000,ko00001,ko01000 - - - Rhodanese k59_1246455_1 1144305.PMI02_05414 4.58e-62 204.0 COG3704@1|root,COG3704@2|Bacteria,1R9F8@1224|Proteobacteria,2U0XT@28211|Alphaproteobacteria,2K3FA@204457|Sphingomonadales 204457|Sphingomonadales U TrbL/VirB6 plasmid conjugal transfer protein - - - ko:K03201 ko03070,map03070 M00333 - - ko00000,ko00001,ko00002,ko02044 3.A.7 - - TrbL k59_1076618_1 1121405.dsmv_0115 2.59e-22 87.8 COG3360@1|root,COG3360@2|Bacteria,1Q2I5@1224|Proteobacteria,42VRR@68525|delta/epsilon subdivisions,2WRD2@28221|Deltaproteobacteria,2MM5C@213118|Desulfobacterales 28221|Deltaproteobacteria S Dodecin - - - ko:K09165 - - - - ko00000 - - - Dodecin k59_286165_1 1122137.AQXF01000001_gene2751 2.79e-65 214.0 COG0007@1|root,COG0007@2|Bacteria,1MUI0@1224|Proteobacteria,2TRJC@28211|Alphaproteobacteria 28211|Alphaproteobacteria H Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme cysG - 1.3.1.76,2.1.1.107,4.99.1.4 ko:K02302,ko:K02303 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R02864,R03194,R03947 RC00003,RC00871,RC01012,RC01034 ko00000,ko00001,ko00002,ko01000 - - - CysG_dimeriser,NAD_binding_7,Sirohm_synth_M,TP_methylase k59_286165_2 400668.Mmwyl1_1084 1.12e-77 238.0 COG0692@1|root,COG0692@2|Bacteria,1MV80@1224|Proteobacteria,1RPDH@1236|Gammaproteobacteria,1XI06@135619|Oceanospirillales 135619|Oceanospirillales L Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine ung - 3.2.2.27 ko:K03648 ko03410,ko05340,map03410,map05340 - - - ko00000,ko00001,ko01000,ko03400 - - - UDG k59_794578_1 765910.MARPU_06265 2.49e-48 179.0 COG2202@1|root,COG3852@1|root,COG2202@2|Bacteria,COG3852@2|Bacteria,1NWNJ@1224|Proteobacteria,1T497@1236|Gammaproteobacteria 1236|Gammaproteobacteria T PAS fold - - - - - - - - - - - - PAS_4 k59_1641886_1 1280953.HOC_15432 1.64e-92 302.0 COG1629@1|root,COG4206@1|root,COG1629@2|Bacteria,COG4206@2|Bacteria,1QU0Y@1224|Proteobacteria,2TWDU@28211|Alphaproteobacteria,440TK@69657|Hyphomonadaceae 28211|Alphaproteobacteria P COG1629 Outer membrane receptor proteins, mostly Fe transport - - - - - - - - - - - - Plug,TonB_dep_Rec k59_173204_1 977880.RALTA_B1110 7.61e-16 83.2 COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,2VHT0@28216|Betaproteobacteria,1K0A3@119060|Burkholderiaceae 28216|Betaproteobacteria C acyl-CoA dehydrogenase - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_1754717_1 748247.AZKH_1043 3.7e-102 311.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2VHSB@28216|Betaproteobacteria,2KVE6@206389|Rhodocyclales 206389|Rhodocyclales T COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains - - - ko:K07715 ko02020,ko02024,map02020,map02024 M00502 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Sigma54_activat k59_568546_2 876044.IMCC3088_275 2.54e-23 93.6 COG0589@1|root,COG0589@2|Bacteria,1RHE6@1224|Proteobacteria,1S6AR@1236|Gammaproteobacteria 1236|Gammaproteobacteria T universal stress protein uspA - - ko:K06149 - - - - ko00000 - - - Usp k59_286179_1 1227266.HMPREF1551_01566 1.96e-35 132.0 COG1235@1|root,COG1235@2|Bacteria,4NDWB@976|Bacteroidetes,1HX58@117743|Flavobacteriia,1EQY9@1016|Capnocytophaga 976|Bacteroidetes S Metallo-beta-lactamase domain protein phnP - 3.1.4.55 ko:K06167 ko00440,map00440 - R10205 RC00296 ko00000,ko00001,ko01000 - - - Lactamase_B_2 k59_511806_1 485915.Dret_0295 2.5e-21 85.9 COG2052@1|root,COG2052@2|Bacteria,1N0KP@1224|Proteobacteria,42TSK@68525|delta/epsilon subdivisions,2WQHH@28221|Deltaproteobacteria,2MCH0@213115|Desulfovibrionales 28221|Deltaproteobacteria S Belongs to the UPF0296 family - - - ko:K09777 - - - - ko00000 - - - DUF370 k59_511806_2 1292034.OR37_00074 1.8e-43 151.0 COG0194@1|root,COG0194@2|Bacteria,1MW92@1224|Proteobacteria,2TSCQ@28211|Alphaproteobacteria,2KGBR@204458|Caulobacterales 204458|Caulobacterales F Essential for recycling GMP and indirectly, cGMP gmk - 2.7.4.8 ko:K00942 ko00230,ko01100,map00230,map01100 M00050 R00332,R02090 RC00002 ko00000,ko00001,ko00002,ko01000 - - - Guanylate_kin k59_511806_3 96561.Dole_2057 1.29e-19 88.2 COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,42M6W@68525|delta/epsilon subdivisions,2WIZF@28221|Deltaproteobacteria,2MIKW@213118|Desulfobacterales 28221|Deltaproteobacteria KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance relA - 2.7.6.5 ko:K00951 ko00230,map00230 - R00429 RC00002,RC00078 ko00000,ko00001,ko01000 - - - ACT_4,HD_4,RelA_SpoT,TGS k59_907168_1 1089552.KI911559_gene3267 3.29e-84 259.0 COG4608@1|root,COG4608@2|Bacteria,1NU4K@1224|Proteobacteria,2TQTV@28211|Alphaproteobacteria,2JPE7@204441|Rhodospirillales 204441|Rhodospirillales E Oligopeptide/dipeptide transporter, C-terminal region - - - ko:K02032 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - ABC_tran,oligo_HPY k59_229313_1 2903.EOD20579 2.43e-22 94.4 COG0572@1|root,KOG4203@2759|Eukaryota 2759|Eukaryota F UMP salvage - - 2.7.1.48 ko:K00876 ko00240,ko00983,ko01100,map00240,map00983,map01100 - R00513,R00516,R00517,R00962,R00964,R00967,R00968,R00970,R01548,R01549,R01880,R02091,R02096,R02097,R02327,R02332,R02371,R02372,R08232 RC00002,RC00017 ko00000,ko00001,ko01000 - - - NPL4,PRK,UN_NPL4 k59_229315_1 646529.Desaci_4364 1.44e-72 233.0 COG3547@1|root,COG3547@2|Bacteria,1V427@1239|Firmicutes,24E1F@186801|Clostridia 186801|Clostridia L transposase IS116 IS110 IS902 family - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_1246478_1 1122137.AQXF01000006_gene721 6.03e-06 46.6 COG0745@1|root,COG0745@2|Bacteria,1QYPQ@1224|Proteobacteria,2TXUW@28211|Alphaproteobacteria 28211|Alphaproteobacteria T Response regulator receiver cheYIII - - - - - - - - - - - Response_reg k59_1246478_2 1122137.AQXF01000006_gene720 1.52e-91 282.0 COG1785@1|root,COG1785@2|Bacteria,1MXI2@1224|Proteobacteria,2TTUZ@28211|Alphaproteobacteria 28211|Alphaproteobacteria P Belongs to the alkaline phosphatase family phoA - 3.1.3.1 ko:K01077 ko00730,ko00790,ko01100,ko02020,map00730,map00790,map01100,map02020 M00126 R02135,R04620 RC00017 ko00000,ko00001,ko00002,ko00537,ko01000,ko04147 - - - Alk_phosphatase k59_342711_1 1049564.TevJSym_ao00320 3.42e-25 104.0 COG3121@1|root,COG3121@2|Bacteria,1RFSJ@1224|Proteobacteria,1S3QQ@1236|Gammaproteobacteria 1236|Gammaproteobacteria NU COG3121 P pilus assembly protein, chaperone PapD - - - - - - - - - - - - PapD_N k59_1189888_1 543913.D521_1166 1.35e-114 354.0 COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,2VIR8@28216|Betaproteobacteria 28216|Betaproteobacteria C aldehyde oxidase and xanthine dehydrogenase, a b hammerhead - - 1.2.5.3 ko:K03520 - - R11168 RC02800 ko00000,ko01000 - - - Ald_Xan_dh_C,Ald_Xan_dh_C2 k59_116839_1 436308.Nmar_1562 3.71e-90 277.0 COG1571@1|root,arCOG01115@2157|Archaea,41S9G@651137|Thaumarchaeota 651137|Thaumarchaeota J ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA tiaS - 6.3.4.22 ko:K06932 - - - - ko00000,ko01000,ko03016 - - - DUF1743 k59_1133352_2 1266908.AQPB01000043_gene1439 1.14e-37 151.0 COG1450@1|root,COG1450@2|Bacteria,1MVNC@1224|Proteobacteria,1RQGJ@1236|Gammaproteobacteria 1236|Gammaproteobacteria NU type II and III secretion system protein mshL - - ko:K12282 - - - - ko00000,ko02044 - - - STN,Secretin,Secretin_N_2 k59_455460_1 1336243.JAEA01000002_gene2720 5.17e-12 69.3 COG4106@1|root,COG4106@2|Bacteria,1R08A@1224|Proteobacteria,2TYN4@28211|Alphaproteobacteria,1JUZX@119045|Methylobacteriaceae 28211|Alphaproteobacteria S Nodulation protein S (NodS) - - - - - - - - - - - - Methyltransf_11 k59_3510_1 1392490.JHZX01000001_gene3466 8.6e-47 159.0 COG0057@1|root,COG0057@2|Bacteria,4NEMF@976|Bacteroidetes,1HYY3@117743|Flavobacteriia 976|Bacteroidetes G Belongs to the glyceraldehyde-3-phosphate dehydrogenase family gap - 1.2.1.12 ko:K00134 ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01061 RC00149 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - Gp_dh_C,Gp_dh_N k59_3510_2 745718.JADT01000019_gene1538 3.07e-87 264.0 COG2971@1|root,COG2971@2|Bacteria,4NEV4@976|Bacteroidetes,1HXM2@117743|Flavobacteriia 976|Bacteroidetes G N-acetylglucosamine kinase - - - - - - - - - - - - BcrAD_BadFG k59_1472385_1 867900.Celly_2591 3.81e-28 111.0 COG2265@1|root,COG2265@2|Bacteria,4PKBS@976|Bacteroidetes,1HXP3@117743|Flavobacteriia,1F8X4@104264|Cellulophaga 976|Bacteroidetes J (SAM)-dependent - - - - - - - - - - - - Cons_hypoth95,Methyltransf_15 k59_116849_1 702113.PP1Y_AT27282 8.22e-33 120.0 COG1521@1|root,COG1521@2|Bacteria,1MUYA@1224|Proteobacteria,2TS5A@28211|Alphaproteobacteria,2K0SW@204457|Sphingomonadales 204457|Sphingomonadales F Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis coaX - 2.7.1.33 ko:K03525 ko00770,ko01100,map00770,map01100 M00120 R02971,R03018,R04391 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - Pan_kinase k59_116849_2 1088721.NSU_4206 1.24e-70 227.0 COG0595@1|root,COG0595@2|Bacteria,1MUGV@1224|Proteobacteria,2TQTR@28211|Alphaproteobacteria,2K04C@204457|Sphingomonadales 204457|Sphingomonadales S metallo-beta-lactamase - - - ko:K12574 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - Lactamase_B,Lactamase_B_2,RMMBL k59_286227_1 702113.PP1Y_AT2438 1.57e-107 318.0 COG3118@1|root,COG3118@2|Bacteria,1MV0R@1224|Proteobacteria,2TS5X@28211|Alphaproteobacteria,2K0HB@204457|Sphingomonadales 204457|Sphingomonadales O Thioredoxin - - - ko:K05838 - - - - ko00000,ko03110 - - - TPR_15,TPR_19,TPR_20,Thioredoxin k59_1359471_1 1288826.MSNKSG1_10103 2.43e-69 225.0 COG3259@1|root,COG3259@2|Bacteria,1QUQ7@1224|Proteobacteria,1T20U@1236|Gammaproteobacteria 1236|Gammaproteobacteria C PFAM Nickel-dependent hydrogenase, large subunit hoxH - - - - - - - - - - - NiFeSe_Hases k59_1020753_1 1535422.ND16A_1602 8.97e-40 140.0 COG1117@1|root,COG1117@2|Bacteria,1MU16@1224|Proteobacteria,1RNUF@1236|Gammaproteobacteria,2Q6I5@267889|Colwelliaceae 1236|Gammaproteobacteria P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system pstB GO:0003674,GO:0003824,GO:0005215,GO:0006810,GO:0006811,GO:0006817,GO:0006820,GO:0008150,GO:0008509,GO:0015075,GO:0015103,GO:0015114,GO:0015318,GO:0015399,GO:0015405,GO:0015415,GO:0015698,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022857,GO:0034220,GO:0035435,GO:0042623,GO:0042626,GO:0043225,GO:0043492,GO:0051179,GO:0051234,GO:0055085,GO:0098656,GO:0098660,GO:0098661,GO:0099133 3.6.3.27 ko:K02036 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.7 - - ABC_tran k59_1020753_2 1268239.PALB_19500 1.2e-11 64.3 COG0581@1|root,COG0581@2|Bacteria,1MUWB@1224|Proteobacteria,1RPV9@1236|Gammaproteobacteria,2PZHW@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria P COG4985 ABC-type phosphate transport system, auxiliary component pstA - - ko:K02038 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - BPD_transp_1 k59_963824_1 1122137.AQXF01000003_gene2307 3.4e-101 301.0 COG4783@1|root,COG4783@2|Bacteria,1QUMJ@1224|Proteobacteria,2TXU6@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Peptidase family M48 - - - - - - - - - - - - Peptidase_M48 k59_1698286_1 1168034.FH5T_14525 6.22e-06 55.1 COG0025@1|root,COG0025@2|Bacteria,4PFE9@976|Bacteroidetes,2FX2R@200643|Bacteroidia 976|Bacteroidetes P Sodium/hydrogen exchanger family - - - - - - - - - - - - Na_H_Exchanger k59_173239_1 1229909.NSED_08235 2.17e-54 174.0 COG0526@1|root,arCOG00314@2157|Archaea,41SKE@651137|Thaumarchaeota 651137|Thaumarchaeota O Redoxin - - - - - - - - - - - - AhpC-TSA k59_342753_1 1458462.JNLK01000001_gene122 9.05e-10 60.5 COG0367@1|root,COG0367@2|Bacteria,1TRPB@1239|Firmicutes,247YA@186801|Clostridia,27JQE@186928|unclassified Lachnospiraceae 186801|Clostridia E Asparagine synthase asnB - 6.3.5.4 ko:K01953 ko00250,ko01100,ko01110,map00250,map01100,map01110 - R00578 RC00010 ko00000,ko00001,ko01000,ko01002 - - - Asn_synthase,GATase_7 k59_681377_1 1469245.JFBG01000030_gene1547 1.26e-27 113.0 COG0628@1|root,COG0628@2|Bacteria,1MXXU@1224|Proteobacteria,1RQCM@1236|Gammaproteobacteria,1WXT8@135613|Chromatiales 135613|Chromatiales S PFAM Uncharacterised protein family UPF0118 - - - - - - - - - - - - AI-2E_transport k59_511866_1 1206744.BAGL01000126_gene6197 1.29e-08 55.8 COG1028@1|root,COG1028@2|Bacteria,2HFQ5@201174|Actinobacteria,4G78D@85025|Nocardiaceae 201174|Actinobacteria IQ KR domain - - 1.1.1.100 ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 k59_1698306_1 1411685.U062_00465 2.29e-34 132.0 COG2304@1|root,COG2304@2|Bacteria,1MW51@1224|Proteobacteria,1RMD3@1236|Gammaproteobacteria,1J59K@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S protein containing a von Willebrand factor type A (vWA) domain - - - ko:K07114 - - - - ko00000,ko02000 1.A.13.2.2,1.A.13.2.3 - - TPR_1,TPR_2,VWA_2 k59_624933_2 395495.Lcho_2038 5.38e-37 134.0 COG2984@1|root,COG2984@2|Bacteria,1MW5D@1224|Proteobacteria,2VIC1@28216|Betaproteobacteria,1KNMK@119065|unclassified Burkholderiales 28216|Betaproteobacteria S ABC transporter substrate binding protein - - - ko:K01989 - M00247 - - ko00000,ko00002,ko02000 - - - ABC_sub_bind k59_1189912_1 519989.ECTPHS_13238 5.1e-94 280.0 COG0081@1|root,COG0081@2|Bacteria,1MUE6@1224|Proteobacteria,1RMDW@1236|Gammaproteobacteria,1WW17@135613|Chromatiales 135613|Chromatiales J Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release rplA - - ko:K02863 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L1 k59_568599_1 1049564.TevJSym_ag00510 1.26e-51 172.0 COG1076@1|root,COG1076@2|Bacteria,1N270@1224|Proteobacteria,1RP0P@1236|Gammaproteobacteria,1J4SR@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host djlA GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0051087,GO:0071944 - ko:K05801 - - - - ko00000,ko03110 - - - DnaJ,TerB k59_286274_1 580332.Slit_1711 9.76e-79 259.0 COG0243@1|root,COG0243@2|Bacteria,1P01N@1224|Proteobacteria,2VKSY@28216|Betaproteobacteria,44WAX@713636|Nitrosomonadales 28216|Betaproteobacteria C Molybdopterin oxidoreductase Fe4S4 domain - - 1.8.5.6 ko:K21307 ko00920,ko01100,ko01120,map00920,map01100,map01120 - R11487 RC00168 ko00000,ko00001,ko01000 - - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding k59_60345_2 159087.Daro_2237 5.42e-57 205.0 COG0419@1|root,COG0419@2|Bacteria,1R4Z9@1224|Proteobacteria,2VMIM@28216|Betaproteobacteria 28216|Betaproteobacteria L ATPase involved in DNA repair - - - ko:K03546 - - - - ko00000,ko03400 - - - - k59_851113_1 519989.ECTPHS_09707 3.26e-74 237.0 COG0469@1|root,COG0469@2|Bacteria,1MU21@1224|Proteobacteria,1RMW3@1236|Gammaproteobacteria,1WXEF@135613|Chromatiales 135613|Chromatiales G Belongs to the pyruvate kinase family - - 2.7.1.40 ko:K00873 ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230 M00001,M00002,M00049,M00050 R00200,R00430,R01138,R01858,R02320 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - PK,PK_C k59_1020802_1 1123059.KB823012_gene2300 1.74e-06 48.9 COG1595@1|root,COG1595@2|Bacteria,1RD9G@1224|Proteobacteria,2U92K@28211|Alphaproteobacteria,43Y7E@69657|Hyphomonadaceae 28211|Alphaproteobacteria K Belongs to the sigma-70 factor family. ECF subfamily - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4,Sigma70_r4_2 k59_1472425_1 1392490.JHZX01000001_gene2298 1.45e-51 176.0 COG0366@1|root,COG0366@2|Bacteria,4NEVK@976|Bacteroidetes,1HYB7@117743|Flavobacteriia 976|Bacteroidetes G alpha amylase, catalytic - - - - - - - - - - - - Alpha-amylase,Alpha-amylase_C,Malt_amylase_C k59_116893_1 439497.RR11_2235 1.85e-98 307.0 COG0471@1|root,COG0471@2|Bacteria,1MU0K@1224|Proteobacteria,2TSFS@28211|Alphaproteobacteria,4NAWE@97050|Ruegeria 28211|Alphaproteobacteria P TrkA-C domain protein - - - - - - - - - - - - CitMHS,Na_sulph_symp,TrkA_C k59_3585_1 436308.Nmar_1776 1.07e-152 434.0 COG1234@1|root,arCOG00501@2157|Archaea,41SF7@651137|Thaumarchaeota 651137|Thaumarchaeota J Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA rnz - 3.1.26.11 ko:K00784 ko03013,map03013 - - - ko00000,ko00001,ko01000,ko03016 - - - Lactamase_B,Lactamase_B_2 k59_3590_1 316407.85676282 2.47e-58 187.0 COG0583@1|root,COG0583@2|Bacteria,1MXXA@1224|Proteobacteria,1RREE@1236|Gammaproteobacteria,3XMXC@561|Escherichia 1236|Gammaproteobacteria K Negatively regulates the transcription of the flagellar master operon flhDC by binding to the upstream region of the operon hdfR GO:0003674,GO:0003700,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0140110,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 - - - - - - - - - - HTH_1,LysR_substrate k59_3590_2 316407.85676281 2.56e-70 212.0 COG3085@1|root,COG3085@2|Bacteria,1RD72@1224|Proteobacteria,1S3NW@1236|Gammaproteobacteria,3XPT4@561|Escherichia 1236|Gammaproteobacteria S Belongs to the UPF0438 family yifE GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006996,GO:0007059,GO:0008150,GO:0009987,GO:0016043,GO:0044424,GO:0044444,GO:0044464,GO:0051276,GO:0071840 - ko:K09897 - - - - ko00000 - - - DUF413 k59_3590_3 316407.85676280 2.08e-51 175.0 COG0606@1|root,COG0606@2|Bacteria,1MU4R@1224|Proteobacteria,1RMB9@1236|Gammaproteobacteria,3XMW9@561|Escherichia 1236|Gammaproteobacteria O ATP-dependent peptidase activity comM GO:0003674,GO:0003824,GO:0004176,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019538,GO:0042623,GO:0043170,GO:0044238,GO:0070011,GO:0071704,GO:0140096,GO:1901564 - ko:K07391 - - - - ko00000 - - - ChlI,Mg_chelatase,Mg_chelatase_C k59_851123_1 1121106.JQKB01000016_gene5356 4.31e-18 77.8 2DMD4@1|root,32NV5@2|Bacteria,1RI0E@1224|Proteobacteria,2UA1F@28211|Alphaproteobacteria,2JZT3@204441|Rhodospirillales 204441|Rhodospirillales S Conserved hypothetical protein (Lin0512_fam) - - - - - - - - - - - - Lin0512_fam k59_1766419_1 436308.Nmar_0314 1.39e-108 317.0 COG1608@1|root,arCOG00860@2157|Archaea,41SI4@651137|Thaumarchaeota 651137|Thaumarchaeota I Amino acid kinase family - - 2.7.4.26 ko:K06981 ko00900,ko01110,ko01130,map00900,map01110,map01130 - R10093 RC00002 ko00000,ko00001,ko01000 - - - AA_kinase k59_806443_1 1123072.AUDH01000001_gene2811 5.61e-43 149.0 COG3836@1|root,COG3836@2|Bacteria,1MUSG@1224|Proteobacteria,2TT2W@28211|Alphaproteobacteria,2JS3C@204441|Rhodospirillales 204441|Rhodospirillales G Belongs to the HpcH HpaI aldolase family - - 2.7.7.38,4.1.2.52 ko:K00979,ko:K02510 ko00350,ko00540,ko01100,ko01120,map00350,map00540,map01100,map01120 M00063 R01645,R01647,R03351,R11396 RC00152,RC00307,RC00572,RC00574,RC00910,RC03057 ko00000,ko00001,ko00002,ko01000,ko01005 - - - HpcH_HpaI k59_636452_1 1535422.ND16A_2982 3.15e-30 123.0 COG3827@1|root,COG3827@2|Bacteria,1QQR0@1224|Proteobacteria,1S068@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_1484717_1 2074.JNYD01000017_gene4290 1.39e-13 78.6 COG2909@1|root,COG3629@1|root,COG2909@2|Bacteria,COG3629@2|Bacteria,2GJAR@201174|Actinobacteria,4EF8E@85010|Pseudonocardiales 201174|Actinobacteria K Bacterial transcriptional activator domain - - - - - - - - - - - - AAA_16,BTAD,Trans_reg_C k59_72495_1 391587.KAOT1_15568 3.26e-98 311.0 COG0366@1|root,COG0366@2|Bacteria,4PMNI@976|Bacteroidetes,1IJVU@117743|Flavobacteriia 976|Bacteroidetes G Alpha amylase, catalytic domain - - - - - - - - - - - - Alpha-amylase k59_298321_1 1163617.SCD_n01354 1.64e-154 448.0 COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,2VMTA@28216|Betaproteobacteria 28216|Betaproteobacteria G Tripartite ATP-independent periplasmic transporter, DctM component - - - - - - - - - - - - DctM,DctQ k59_1596910_1 232721.Ajs_0011 1.87e-24 102.0 COG2197@1|root,COG2197@2|Bacteria,1P4TD@1224|Proteobacteria,2VMX4@28216|Betaproteobacteria,4AC4K@80864|Comamonadaceae 28216|Betaproteobacteria K response regulator vsrC - - - - - - - - - - - GerE,Response_reg k59_1596910_2 1415779.JOMH01000001_gene2583 8.3e-30 117.0 COG0129@1|root,COG0129@2|Bacteria,1MUTQ@1224|Proteobacteria,1RMP2@1236|Gammaproteobacteria,1X4TP@135614|Xanthomonadales 135614|Xanthomonadales E Belongs to the IlvD Edd family - - - - - - - - - - - - ILVD_EDD k59_1032874_1 391615.ABSJ01000042_gene2265 4.22e-70 231.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,1RMH0@1236|Gammaproteobacteria,1J7RG@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria NT Type IV pili methyl-accepting chemotaxis transducer N-term pilJ - - ko:K02660 ko02020,ko02025,map02020,map02025 - - - ko00000,ko00001,ko02035,ko02044 - - - MCPsignal,PilJ k59_974713_1 909663.KI867150_gene122 3.77e-11 66.2 COG0491@1|root,COG0491@2|Bacteria,1MUDN@1224|Proteobacteria,42QWD@68525|delta/epsilon subdivisions,2WNNG@28221|Deltaproteobacteria,2MRMK@213462|Syntrophobacterales 28221|Deltaproteobacteria S Metallo-beta-lactamase superfamily - - - - - - - - - - - - Lactamase_B k59_974713_2 1051632.TPY_2912 4.03e-41 146.0 COG0730@1|root,COG0730@2|Bacteria 2|Bacteria S response to heat - - - ko:K07090 - - - - ko00000 - - - TauE k59_692917_1 313596.RB2501_07245 1.57e-64 209.0 COG0491@1|root,COG0607@1|root,COG0491@2|Bacteria,COG0607@2|Bacteria,4NE2Y@976|Bacteroidetes,1HYF1@117743|Flavobacteriia 976|Bacteroidetes P COG0491 Zn-dependent hydrolases, including glyoxylases - - - - - - - - - - - - Lactamase_B,Rhodanese k59_692917_2 1286632.P278_20950 5.36e-28 108.0 COG0730@1|root,COG0730@2|Bacteria,4NFWP@976|Bacteroidetes,1HWSW@117743|Flavobacteriia 976|Bacteroidetes S membrane transporter protein - - - ko:K07090 - - - - ko00000 - - - TauE k59_579988_1 261292.Nit79A3_2268 8.77e-13 69.7 COG4782@1|root,COG4782@2|Bacteria,1N9HN@1224|Proteobacteria 1224|Proteobacteria S Alpha/beta hydrolase of unknown function (DUF900) - - - - - - - - - - - - DUF900 k59_579988_2 69395.JQLZ01000006_gene2223 7.4e-06 53.5 2E84E@1|root,332I4@2|Bacteria,1NFMY@1224|Proteobacteria,2UHDE@28211|Alphaproteobacteria,2KJ47@204458|Caulobacterales 204458|Caulobacterales - - - - - - - - - - - - - - - k59_579988_3 633131.TR2A62_1211 3.26e-15 74.3 COG2020@1|root,COG2020@2|Bacteria,1MZ7S@1224|Proteobacteria,2UBYC@28211|Alphaproteobacteria 28211|Alphaproteobacteria O Methyltransferase - - - - - - - - - - - - PEMT k59_1032885_1 436308.Nmar_1597 4.06e-116 344.0 COG0043@1|root,arCOG01671@2157|Archaea,41SEQ@651137|Thaumarchaeota 651137|Thaumarchaeota H UbiD family decarboxylase - - - - - - - - - - - - UbiD k59_240952_1 1122247.C731_4846 3.62e-33 125.0 COG0451@1|root,COG0451@2|Bacteria,2GN90@201174|Actinobacteria,2349J@1762|Mycobacteriaceae 201174|Actinobacteria GM epimerase dehydratase - - 1.1.1.219 ko:K00091 - - - - ko00000,ko01000 - - - Epimerase k59_974724_1 1397527.Q670_03070 2.02e-32 127.0 COG0581@1|root,COG0581@2|Bacteria,1MUWB@1224|Proteobacteria,1RPV9@1236|Gammaproteobacteria,1XJ28@135619|Oceanospirillales 135619|Oceanospirillales P Phosphate transport system permease pstA - - ko:K02038 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - BPD_transp_1,DUF3333 k59_240955_1 713586.KB900536_gene2898 6.44e-71 226.0 COG0247@1|root,COG0247@2|Bacteria,1MWTK@1224|Proteobacteria,1RQ9M@1236|Gammaproteobacteria,1WX1I@135613|Chromatiales 135613|Chromatiales C Cysteine-rich domain - - - - - - - - - - - - CCG k59_354815_1 566466.NOR53_2711 4.46e-83 270.0 COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,1RMZ8@1236|Gammaproteobacteria,1J59D@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria I Involved in the aerobic and anaerobic degradation of long-chain fatty acids via beta-oxidation cycle. Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA. It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate fadB - 1.1.1.35,4.2.1.17,5.1.2.3,5.3.3.8 ko:K01782,ko:K01825 ko00071,ko00280,ko00281,ko00310,ko00362,ko00380,ko00410,ko00640,ko00650,ko00903,ko00930,ko01040,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00362,map00380,map00410,map00640,map00650,map00903,map00930,map01040,map01100,map01110,map01120,map01130,map01200,map01212 M00032,M00087 R01975,R03026,R03045,R03276,R04137,R04170,R04203,R04204,R04224,R04737,R04738,R04739,R04740,R04741,R04744,R04745,R04746,R04748,R04749,R04756,R05066,R05305,R06411,R06412,R06941,R06942,R07935,R07951,R08093,R08094 RC00029,RC00099,RC00117,RC00241,RC00525,RC00831,RC00834,RC00896,RC01078,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 - - - 3HCDH,3HCDH_N,ECH_1 k59_1709885_1 926569.ANT_25010 2e-173 494.0 COG1509@1|root,COG1509@2|Bacteria,2G7ZT@200795|Chloroflexi 200795|Chloroflexi H Lysine-2,3-aminomutase - - 5.4.3.2 ko:K01843 ko00310,map00310 - R00461 RC00303 ko00000,ko00001,ko01000 - - - Acetyltransf_1,LAM_C,Radical_SAM k59_749327_1 706587.Desti_1151 2.15e-38 140.0 COG3547@1|root,COG3547@2|Bacteria,1MXKJ@1224|Proteobacteria,42RYH@68525|delta/epsilon subdivisions,2WNT0@28221|Deltaproteobacteria 28221|Deltaproteobacteria L PFAM transposase IS116 IS110 IS902 family - - - ko:K07486 - - - - ko00000 - - - DEDD_Tnp_IS110,Transposase_20 k59_580019_1 316407.85675604 1.67e-118 348.0 COG2265@1|root,COG2265@2|Bacteria,1MV3A@1224|Proteobacteria,1RN1D@1236|Gammaproteobacteria,3XNZV@561|Escherichia 1236|Gammaproteobacteria J Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA rlmD GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005488,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016436,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0070041,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.190 ko:K03215 - - - - ko00000,ko01000,ko03009 - - - TRAM,tRNA_U5-meth_tr k59_298354_2 1121479.AUBS01000041_gene662 4.03e-88 266.0 COG0356@1|root,COG0356@2|Bacteria,1MV87@1224|Proteobacteria,2U06M@28211|Alphaproteobacteria 28211|Alphaproteobacteria C it plays a direct role in the translocation of protons across the membrane atpB_1 - - ko:K02108 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko03110 3.A.2.1 - - ATP-synt_A k59_298354_4 1123237.Salmuc_00553 3.59e-33 117.0 2CBNW@1|root,32RTR@2|Bacteria,1N7RB@1224|Proteobacteria,2UFXQ@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Putative F0F1-ATPase subunit Ca2+/Mg2+ transporter - - - ko:K02116 - - - - ko00000,ko00194 3.A.2.1 - - ATPase_gene1 k59_1484757_1 1122225.AULQ01000001_gene1844 2.71e-98 312.0 COG0612@1|root,COG0612@2|Bacteria,4NEDZ@976|Bacteroidetes,1HYRS@117743|Flavobacteriia 976|Bacteroidetes M Peptidase M16 - - - ko:K07263 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M16,Peptidase_M16_C k59_522907_1 1280941.HY2_11705 1.64e-13 78.6 COG1566@1|root,COG1566@2|Bacteria,1N1WR@1224|Proteobacteria,2VGP8@28211|Alphaproteobacteria,43XX1@69657|Hyphomonadaceae 28211|Alphaproteobacteria V Protein of unknown function (DUF3667) - - - - - - - - - - - - DUF3667 k59_863523_1 1336245.JAGO01000010_gene924 1.8e-45 166.0 COG0578@1|root,COG0578@2|Bacteria,1MUMY@1224|Proteobacteria,1RMGP@1236|Gammaproteobacteria,1XHBK@135619|Oceanospirillales 135619|Oceanospirillales C Glycerol-3-phosphate dehydrogenase glpD - 1.1.1.402,1.1.5.3 ko:K00111,ko:K21054 ko00564,ko01110,map00564,map01110 - R00848 RC00029 ko00000,ko00001,ko01000 - - - DAO,DAO_C k59_354839_2 870187.Thini_3079 5.2e-17 78.2 COG1218@1|root,COG1218@2|Bacteria,1N0GY@1224|Proteobacteria,1RP5A@1236|Gammaproteobacteria,460I9@72273|Thiotrichales 72273|Thiotrichales P Inositol monophosphatase family - - 3.1.3.7 ko:K01082 ko00920,ko01100,ko01120,ko01130,map00920,map01100,map01120,map01130 - R00188,R00508 RC00078 ko00000,ko00001,ko01000,ko03016 - - - Inositol_P k59_749348_1 977880.RALTA_A0188 1.12e-89 276.0 COG0499@1|root,COG0499@2|Bacteria,1MUQ2@1224|Proteobacteria,2VH57@28216|Betaproteobacteria,1K11D@119060|Burkholderiaceae 28216|Betaproteobacteria H May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine ahcY GO:0000096,GO:0000097,GO:0000166,GO:0001666,GO:0002376,GO:0002437,GO:0002439,GO:0002544,GO:0003674,GO:0003824,GO:0004013,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006152,GO:0006520,GO:0006534,GO:0006555,GO:0006575,GO:0006725,GO:0006732,GO:0006790,GO:0006807,GO:0006950,GO:0006952,GO:0006954,GO:0006955,GO:0007584,GO:0007610,GO:0007622,GO:0007623,GO:0008150,GO:0008152,GO:0008652,GO:0009056,GO:0009058,GO:0009063,GO:0009066,GO:0009069,GO:0009116,GO:0009119,GO:0009164,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0016053,GO:0016054,GO:0016787,GO:0016801,GO:0016802,GO:0017076,GO:0017144,GO:0019439,GO:0019510,GO:0019752,GO:0030554,GO:0031667,GO:0033353,GO:0034641,GO:0034655,GO:0034656,GO:0036094,GO:0036293,GO:0042219,GO:0042221,GO:0042278,GO:0042454,GO:0042745,GO:0042802,GO:0042995,GO:0043005,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044272,GO:0044273,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046128,GO:0046130,GO:0046394,GO:0046395,GO:0046439,GO:0046483,GO:0046498,GO:0046500,GO:0046700,GO:0048037,GO:0048511,GO:0048512,GO:0050662,GO:0050667,GO:0050896,GO:0051186,GO:0051187,GO:0051287,GO:0055086,GO:0070482,GO:0071268,GO:0071704,GO:0072521,GO:0072523,GO:0097159,GO:0097458,GO:0098604,GO:0120025,GO:1901135,GO:1901136,GO:1901265,GO:1901360,GO:1901361,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1901607,GO:1901657,GO:1901658 3.3.1.1 ko:K01251 ko00270,ko01100,map00270,map01100 M00035 R00192,R04936 RC00056,RC00069,RC01161,RC01243 ko00000,ko00001,ko00002,ko01000,ko01009,ko04147 - - - AdoHcyase,AdoHcyase_NAD k59_15345_1 1238450.VIBNISOn1_920003 4.38e-34 137.0 COG1629@1|root,COG4771@2|Bacteria,1MX42@1224|Proteobacteria,1RQ2K@1236|Gammaproteobacteria,1XT4R@135623|Vibrionales 135623|Vibrionales P COG1629 Outer membrane receptor proteins, mostly Fe transport - - - ko:K16087 - - - - ko00000,ko02000 1.B.14.2 - - Plug,TonB_dep_Rec k59_580032_1 1121396.KB892918_gene93 1.03e-111 350.0 COG0531@1|root,COG0531@2|Bacteria,1R4IZ@1224|Proteobacteria,42MTQ@68525|delta/epsilon subdivisions,2WK39@28221|Deltaproteobacteria,2MIIG@213118|Desulfobacterales 28221|Deltaproteobacteria E Amino acid permease - - - - - - - - - - - - AA_permease,SLC12 k59_580032_3 710686.Mycsm_05709 1.41e-74 241.0 COG0212@1|root,COG0212@2|Bacteria,2I75G@201174|Actinobacteria,23FH6@1762|Mycobacteriaceae 201174|Actinobacteria H Belongs to the 5-formyltetrahydrofolate cyclo-ligase family - - - - - - - - - - - - - k59_919001_1 1395571.TMS3_0107135 6.47e-74 232.0 COG0535@1|root,COG0535@2|Bacteria,1MU07@1224|Proteobacteria,1RN94@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Radical SAM - - - - - - - - - - - - DUF3641,Fer4_12,Radical_SAM k59_863532_1 981085.XP_010088417.1 3e-15 75.9 COG1850@1|root,2QTI9@2759|Eukaryota,37HQX@33090|Viridiplantae,3GDC3@35493|Streptophyta,4JS2T@91835|fabids 35493|Streptophyta C Ribulose bisphosphate carboxylase, large chain rbcL GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0009507,GO:0009536,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464 2.1.3.15,4.1.1.39,6.4.1.2 ko:K01601,ko:K01963 ko00061,ko00620,ko00630,ko00640,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00630,map00640,map00710,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00165,M00166,M00376,M00532 R00024,R00742,R03140,R04386 RC00040,RC00172,RC00253,RC00367,RC00859 ko00000,ko00001,ko00002,ko01000 - - - RuBisCO_large,RuBisCO_large_N k59_298378_2 1536770.R50345_05895 2.77e-29 114.0 COG3723@1|root,COG3723@2|Bacteria,1UNDF@1239|Firmicutes,4HB2T@91061|Bacilli,26XPY@186822|Paenibacillaceae 91061|Bacilli L repair protein recT - - ko:K07455 - - - - ko00000,ko03400 - - - RecT k59_128526_1 1268303.RHODMAR_4419 5.04e-06 52.0 COG1301@1|root,COG1301@2|Bacteria,2I9I7@201174|Actinobacteria,4FY53@85025|Nocardiaceae 201174|Actinobacteria U Sodium:dicarboxylate symporter family - - - - - - - - - - - - SDF k59_128526_2 316275.VSAL_I1797 9.75e-45 159.0 COG0668@1|root,COG0668@2|Bacteria,1N596@1224|Proteobacteria,1RQZP@1236|Gammaproteobacteria,1XVNX@135623|Vibrionales 135623|Vibrionales M Small-conductance mechanosensitive channel - - - ko:K03442 - - - - ko00000,ko02000 1.A.23.2 - - MS_channel k59_636508_1 1122138.AQUZ01000004_gene1005 1.8e-27 111.0 COG4695@1|root,COG4695@2|Bacteria,2I9PX@201174|Actinobacteria,4DWCY@85009|Propionibacteriales 201174|Actinobacteria S Phage portal protein - - - - - - - - - - - - Phage_portal k59_636508_2 1122138.AQUZ01000004_gene1004 5.69e-24 96.7 COG3740@1|root,COG3740@2|Bacteria,2IDPK@201174|Actinobacteria,4DWCW@85009|Propionibacteriales 201174|Actinobacteria S Caudovirus prohead serine protease - - - ko:K06904 - - - - ko00000 - - - Peptidase_S78 k59_1653978_1 1242864.D187_005635 8.98e-25 102.0 COG0138@1|root,COG0138@2|Bacteria,1MUDQ@1224|Proteobacteria,42MV4@68525|delta/epsilon subdivisions,2WKHZ@28221|Deltaproteobacteria,2YTYA@29|Myxococcales 28221|Deltaproteobacteria F Bifunctional purine biosynthesis protein PurH purH - 2.1.2.3,3.5.4.10 ko:K00602 ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523 M00048 R01127,R04560 RC00026,RC00263,RC00456 ko00000,ko00001,ko00002,ko01000,ko04147 - - - AICARFT_IMPCHas,MGS k59_1653978_2 906968.Trebr_0656 2.24e-29 115.0 COG0299@1|root,COG0299@2|Bacteria,2J820@203691|Spirochaetes 203691|Spirochaetes F Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate purN - 2.1.2.2 ko:K11175 ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130 M00048 R04325,R04326 RC00026,RC00197,RC01128 ko00000,ko00001,ko00002,ko01000 - - - Formyl_trans_N k59_1032965_1 1247726.MIM_c14560 4.49e-49 166.0 COG2877@1|root,COG2877@2|Bacteria,1MV91@1224|Proteobacteria,2VIQF@28216|Betaproteobacteria,3T329@506|Alcaligenaceae 28216|Betaproteobacteria M Belongs to the KdsA family kdsA - 2.5.1.55 ko:K01627 ko00540,ko01100,map00540,map01100 M00063 R03254 RC00435 ko00000,ko00001,ko00002,ko01000,ko01005 - - - DAHP_synth_1 k59_1427173_1 436308.Nmar_0284 5.67e-186 528.0 COG0651@1|root,arCOG01537@2157|Archaea,41SAV@651137|Thaumarchaeota 651137|Thaumarchaeota C plastoquinone (complex I) - - 1.6.5.3 ko:K00342,ko:K12137,ko:K12141 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Proton_antipo_M k59_1596984_1 258594.RPA2590 6.7e-35 136.0 COG0245@1|root,COG1211@1|root,COG0245@2|Bacteria,COG1211@2|Bacteria,1MVHA@1224|Proteobacteria,2TRQC@28211|Alphaproteobacteria,3JSCM@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria I Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl- D-erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2- phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4- cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF) ispDF - 2.7.7.60,4.6.1.12 ko:K01770,ko:K12506 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05633,R05637 RC00002,RC01440 ko00000,ko00001,ko00002,ko01000 - - - IspD,YgbB k59_1596984_2 1034345.CAEM01000023_gene891 2.73e-52 171.0 COG0245@1|root,COG0245@2|Bacteria,2II8H@201174|Actinobacteria,4CW0D@84998|Coriobacteriia 84998|Coriobacteriia H Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) ispF - 4.6.1.12 ko:K01770 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05637 RC00002,RC01440 ko00000,ko00001,ko00002,ko01000 - - - YgbB k59_1596984_3 291985.CCSI01000005_gene887 3.71e-29 115.0 COG0215@1|root,COG0215@2|Bacteria,1MV8H@1224|Proteobacteria,2TQQ1@28211|Alphaproteobacteria,2K19T@204457|Sphingomonadales 204457|Sphingomonadales J Belongs to the class-I aminoacyl-tRNA synthetase family cysS - 6.1.1.16 ko:K01883 ko00970,map00970 M00359,M00360 R03650 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DALR_2,tRNA-synt_1e k59_580053_1 1122137.AQXF01000005_gene1052 5.17e-32 115.0 COG4103@1|root,COG4103@2|Bacteria,1N6YZ@1224|Proteobacteria,2U93G@28211|Alphaproteobacteria 28211|Alphaproteobacteria S protein conserved in bacteria - - - - - - - - - - - - TerB k59_580053_2 1346791.M529_08085 5.61e-46 162.0 COG1866@1|root,COG1866@2|Bacteria,1MWXN@1224|Proteobacteria,2TRC4@28211|Alphaproteobacteria,2JZZG@204457|Sphingomonadales 204457|Sphingomonadales H Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA pckA - 4.1.1.49 ko:K01610 ko00010,ko00020,ko00620,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00710,map01100,map01110,map01120,map01130,map01200 M00003,M00170 R00341 RC00002,RC02741 ko00000,ko00001,ko00002,ko01000 - - - PEPCK_ATP k59_580053_3 1122137.AQXF01000001_gene2973 9.15e-166 476.0 COG1866@1|root,COG1866@2|Bacteria,1MWXN@1224|Proteobacteria,2TRC4@28211|Alphaproteobacteria 28211|Alphaproteobacteria H Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA pckA GO:0003674,GO:0003824,GO:0004611,GO:0004612,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006094,GO:0008150,GO:0008152,GO:0009058,GO:0016051,GO:0016829,GO:0016830,GO:0016831,GO:0019318,GO:0019319,GO:0044238,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046364,GO:0071704,GO:1901576 4.1.1.49 ko:K01610 ko00010,ko00020,ko00620,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00710,map01100,map01110,map01120,map01130,map01200 M00003,M00170 R00341 RC00002,RC02741 ko00000,ko00001,ko00002,ko01000 - - - PEPCK_ATP k59_1709941_1 1123315.AUIP01000019_gene2176 1.36e-06 59.3 COG0507@1|root,COG0507@2|Bacteria,1TPZH@1239|Firmicutes,4HATQ@91061|Bacilli 91061|Bacilli L DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity recD2 - 3.1.11.5 ko:K03581 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - AAA_30,HHH_4,HHH_5,UvrD_C_2 k59_1653993_1 1283300.ATXB01000001_gene2296 4.06e-49 159.0 COG0347@1|root,COG0347@2|Bacteria,1RI28@1224|Proteobacteria,1S62Z@1236|Gammaproteobacteria,1XFB1@135618|Methylococcales 135618|Methylococcales K Nitrogen regulatory protein P-II - - - - - - - - - - - - - k59_1653993_2 675814.VIC_000275 3.61e-21 87.4 COG2905@1|root,COG2905@2|Bacteria,1MZGY@1224|Proteobacteria,1S86K@1236|Gammaproteobacteria,1XXFK@135623|Vibrionales 135623|Vibrionales T COG0517 FOG CBS domain - - - - - - - - - - - - CBS k59_806568_1 1121887.AUDK01000016_gene1902 9.82e-94 298.0 COG3250@1|root,COG3250@2|Bacteria,4NEWN@976|Bacteroidetes,1HXYF@117743|Flavobacteriia,2NVHB@237|Flavobacterium 976|Bacteroidetes G Belongs to the glycosyl hydrolase 2 family - - 3.2.1.23 ko:K01190 ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100 - R01105,R01678,R03355,R04783,R06114 RC00049,RC00452 ko00000,ko00001,ko01000 - - - DUF4982,Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N k59_806568_2 398720.MED217_17670 9.72e-20 87.4 COG0823@1|root,COG3507@1|root,COG0823@2|Bacteria,COG3507@2|Bacteria,4NHV4@976|Bacteroidetes,1I0TR@117743|Flavobacteriia 976|Bacteroidetes G Glycosyl hydrolases family 43 - - - - - - - - - - - - Glyco_hydro_43 k59_692999_2 240016.ABIZ01000001_gene1788 6.63e-31 115.0 2FD8F@1|root,345AF@2|Bacteria,46WA3@74201|Verrucomicrobia 74201|Verrucomicrobia - - - - - - - - - - - - - - - k59_919035_1 1335757.SPICUR_07315 1.05e-119 360.0 COG1217@1|root,COG1217@2|Bacteria,1MV5Q@1224|Proteobacteria,1RMJB@1236|Gammaproteobacteria,1WW7K@135613|Chromatiales 135613|Chromatiales T GTP-binding protein TypA - - - ko:K06207 - - - - ko00000 - - - EFG_C,GTP_EFTU,GTP_EFTU_D2 k59_974813_1 589873.EP13_13400 1.51e-22 91.7 COG1435@1|root,COG1435@2|Bacteria,1NJR4@1224|Proteobacteria,1RPCK@1236|Gammaproteobacteria,464P5@72275|Alteromonadaceae 1236|Gammaproteobacteria F thymidine kinase tdk GO:0003674,GO:0003824,GO:0004797,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006213,GO:0006259,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009120,GO:0009123,GO:0009124,GO:0009157,GO:0009162,GO:0009165,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0018130,GO:0019136,GO:0019205,GO:0019206,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046104,GO:0046125,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0090304,GO:0090407,GO:1901135,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901576,GO:1901657 2.7.1.21 ko:K00857 ko00240,ko00983,ko01100,map00240,map00983,map01100 - R01567,R02099,R08233 RC00002,RC00017 ko00000,ko00001,ko01000 - - iAF1260.b1238,iBWG_1329.BWG_1065,iECDH10B_1368.ECDH10B_1298,iECDH1ME8569_1439.ECDH1ME8569_1176,iEcDH1_1363.EcDH1_2411,iJO1366.b1238,iJR904.b1238,iPC815.YPO2176,iY75_1357.Y75_RS06470 TK k59_974813_2 1343158.SACS_0359 4.14e-08 56.2 COG1816@1|root,COG1816@2|Bacteria,1R6Q8@1224|Proteobacteria,2U0BN@28211|Alphaproteobacteria,2JQP7@204441|Rhodospirillales 204441|Rhodospirillales F Adenosine/AMP deaminase add - 3.5.4.4 ko:K01488 ko00230,ko01100,ko05340,map00230,map01100,map05340 - R01560,R02556 RC00477 ko00000,ko00001,ko01000 - - - A_deaminase k59_1766533_1 713586.KB900536_gene2887 9.77e-51 165.0 COG1225@1|root,COG1225@2|Bacteria,1RD4R@1224|Proteobacteria,1RQ7F@1236|Gammaproteobacteria,1WY4F@135613|Chromatiales 135613|Chromatiales O alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen - - 1.11.1.15 ko:K03564 - - - - ko00000,ko01000 - - - AhpC-TSA k59_1766533_2 1260251.SPISAL_02180 1.09e-08 54.3 COG2716@1|root,COG2716@2|Bacteria,1R7W7@1224|Proteobacteria,1RSDP@1236|Gammaproteobacteria,1WWJB@135613|Chromatiales 135613|Chromatiales E PFAM Amino acid-binding ACT - - - ko:K03567 ko02026,map02026 - - - ko00000,ko00001,ko03000 - - - ACT_6 k59_354893_1 1049564.TevJSym_ab00110 1.63e-10 64.7 COG3221@1|root,COG3221@2|Bacteria,1RKVE@1224|Proteobacteria,1S8D7@1236|Gammaproteobacteria 1236|Gammaproteobacteria P ABC transporter, phosphonate, periplasmic substrate-binding protein - - - ko:K02044 ko02010,map02010 M00223 - - ko00000,ko00001,ko00002,ko02000 3.A.1.9 - - Phosphonate-bd k59_580073_1 1120919.AUBI01000019_gene3425 0.000157 50.1 COG0154@1|root,COG0154@2|Bacteria,1MW3Z@1224|Proteobacteria,2TS56@28211|Alphaproteobacteria,2JP87@204441|Rhodospirillales 204441|Rhodospirillales J Amidase - - 6.3.5.6,6.3.5.7 ko:K02433 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - Amidase k59_298431_1 1088721.NSU_0847 1.32e-105 319.0 COG1292@1|root,COG1292@2|Bacteria,1MV0K@1224|Proteobacteria,2TQR4@28211|Alphaproteobacteria,2K2SA@204457|Sphingomonadales 204457|Sphingomonadales M Belongs to the BCCT transporter (TC 2.A.15) family - - - ko:K02168 - - - - ko00000,ko02000 2.A.15.1.3,2.A.15.1.4 - - BCCT k59_749407_1 713587.THITH_07660 3.34e-74 242.0 COG0511@1|root,COG5016@1|root,COG0511@2|Bacteria,COG5016@2|Bacteria,1QTTG@1224|Proteobacteria,1RNG6@1236|Gammaproteobacteria,1WW0Z@135613|Chromatiales 135613|Chromatiales CI TIGRFAM Oxaloacetate decarboxylase, alpha subunit - - 6.4.1.1 ko:K01960 ko00020,ko00620,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00720,map01100,map01120,map01200,map01230 M00173,M00620 R00344 RC00040,RC00367 ko00000,ko00001,ko00002,ko01000 - - - Biotin_lipoyl,HMGL-like,PYC_OADA k59_354902_1 1499686.BN1079_02344 4.33e-84 262.0 COG0161@1|root,COG0161@2|Bacteria,1MU2N@1224|Proteobacteria,1RNW9@1236|Gammaproteobacteria 1236|Gammaproteobacteria E Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family spuC - 2.6.1.113 ko:K12256 ko00330,ko01100,map00330,map01100 - R08714 RC00008,RC00062 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_3 k59_1654020_1 436308.Nmar_1396 7.86e-68 217.0 COG1522@1|root,arCOG04153@2157|Archaea,41SP6@651137|Thaumarchaeota 651137|Thaumarchaeota K COG1522 Transcriptional regulators - - - - - - - - - - - - - k59_1654020_2 436308.Nmar_1395 3.36e-57 182.0 COG0293@1|root,arCOG00079@2157|Archaea,41SIK@651137|Thaumarchaeota 651137|Thaumarchaeota J Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit rlmE - 2.1.1.166 ko:K02427 - - - - ko00000,ko01000,ko03009 - - - FtsJ k59_974827_1 1121923.GPUN_0412 3.45e-26 109.0 COG1629@1|root,COG4771@2|Bacteria,1MUF1@1224|Proteobacteria,1RQF8@1236|Gammaproteobacteria,469J0@72275|Alteromonadaceae 1236|Gammaproteobacteria P TonB dependent receptor - - - - - - - - - - - - TonB_dep_Rec k59_974827_2 1381123.AYOD01000035_gene3382 1.4e-44 150.0 COG0625@1|root,COG0625@2|Bacteria,1MUN3@1224|Proteobacteria,2TTVR@28211|Alphaproteobacteria,43I9I@69277|Phyllobacteriaceae 28211|Alphaproteobacteria O Belongs to the GST superfamily yfcG - - ko:K11209 - - - - ko00000,ko01000 - - - GST_C,GST_C_2,GST_N,GST_N_3 k59_749411_1 318167.Sfri_1827 2.27e-17 81.3 COG2303@1|root,COG2303@2|Bacteria,1RH5U@1224|Proteobacteria,1S60X@1236|Gammaproteobacteria 1236|Gammaproteobacteria E Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate - - - - - - - - - - - - - k59_466874_1 384765.SIAM614_23397 8.66e-144 413.0 COG0798@1|root,COG0798@2|Bacteria,1MUXY@1224|Proteobacteria,2TSVJ@28211|Alphaproteobacteria 28211|Alphaproteobacteria P COG0798 Arsenite efflux pump ACR3 and related permeases arsB - - ko:K03325 - - - - ko00000,ko02000 2.A.59 - - SBF k59_1709986_1 1178825.ALIH01000012_gene1847 3.83e-109 324.0 COG2195@1|root,COG2195@2|Bacteria,4NE7N@976|Bacteroidetes,1HWV8@117743|Flavobacteriia 976|Bacteroidetes E Cleaves the N-terminal amino acid of tripeptides pepT - 3.4.11.4 ko:K01258 - - - - ko00000,ko01000,ko01002 - - - M20_dimer,Peptidase_M20 k59_1314956_2 1415778.JQMM01000001_gene1405 4.86e-77 246.0 COG0204@1|root,COG3176@1|root,COG0204@2|Bacteria,COG3176@2|Bacteria,1MWIM@1224|Proteobacteria,1RQD4@1236|Gammaproteobacteria,1J51K@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria I Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_5,Acyltransferase k59_1766555_1 436308.Nmar_1392 1.77e-11 62.4 COG0513@1|root,arCOG00078@2157|Archaea,41SM2@651137|Thaumarchaeota 651137|Thaumarchaeota J Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA flpA - - ko:K04795 - - - - ko00000,ko03009 - - - Fibrillarin k59_1202846_1 1120983.KB894572_gene3159 4e-39 143.0 COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,2TVI3@28211|Alphaproteobacteria,1JN67@119043|Rhodobiaceae 28211|Alphaproteobacteria S Tripartite tricarboxylate transporter TctA family - - - - - - - - - - - - TctA k59_1767562_1 1232410.KI421418_gene2189 6.8e-85 274.0 COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MU0R@1224|Proteobacteria,42NDJ@68525|delta/epsilon subdivisions,2WJSH@28221|Deltaproteobacteria,43S61@69541|Desulfuromonadales 28221|Deltaproteobacteria G Pyruvate phosphate dikinase, PEP/pyruvate binding domain ppdK - 2.7.9.1 ko:K01006 ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200 M00169,M00171,M00172,M00173 R00206 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - PEP-utilizers,PEP-utilizers_C,PPDK_N k59_467967_1 1121937.AUHJ01000003_gene3274 2.09e-77 254.0 COG4774@1|root,COG4774@2|Bacteria,1NMCN@1224|Proteobacteria,1T3TQ@1236|Gammaproteobacteria,46DC7@72275|Alteromonadaceae 1236|Gammaproteobacteria P TonB dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_411584_1 1042377.AFPJ01000010_gene1483 2.09e-122 365.0 COG0173@1|root,COG0173@2|Bacteria,1MUXB@1224|Proteobacteria,1RNMI@1236|Gammaproteobacteria,46435@72275|Alteromonadaceae 1236|Gammaproteobacteria J Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) aspS GO:0003674,GO:0003824,GO:0004812,GO:0004815,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006422,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.12 ko:K01876 ko00970,map00970 M00359,M00360 R05577 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - iSFV_1184.SFV_1868 GAD,tRNA-synt_2,tRNA_anti-codon k59_1485949_1 1429851.X548_08760 3.89e-64 212.0 COG1070@1|root,COG1070@2|Bacteria,1MW4A@1224|Proteobacteria,1RR7X@1236|Gammaproteobacteria,1X4TN@135614|Xanthomonadales 135614|Xanthomonadales G Xylulose kinase xylB - 2.7.1.17 ko:K00854 ko00040,ko01100,map00040,map01100 M00014 R01639 RC00002,RC00538 ko00000,ko00001,ko00002,ko01000 - - - FGGY_C,FGGY_N k59_637614_1 566466.NOR53_631 3.6e-112 340.0 COG2303@1|root,COG2303@2|Bacteria,1MU3F@1224|Proteobacteria,1RPBQ@1236|Gammaproteobacteria,1J5ZV@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E COG2303 Choline dehydrogenase and related flavoproteins - - 1.1.99.3 ko:K06151 ko00030,ko01100,ko01120,map00030,map01100,map01120 - R01741 RC00084 ko00000,ko00001,ko01000 - - - FAD_binding_2,GMC_oxred_C,GMC_oxred_N,NAD_binding_8 k59_1661736_1 717605.Theco_4080 7.27e-49 175.0 COG0553@1|root,COG0553@2|Bacteria,1TPFZ@1239|Firmicutes,4HAIF@91061|Bacilli 91061|Bacilli L Superfamily II DNA RNA helicases, SNF2 family' - - - - - - - - - - - - Helicase_C,SNF2_N k59_81316_1 880073.Calab_2935 2.65e-18 87.4 COG3005@1|root,COG3005@2|Bacteria,2NQ9M@2323|unclassified Bacteria 2|Bacteria C NapC/NirT cytochrome c family, N-terminal region - GO:0003674,GO:0003824,GO:0005575,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0022900,GO:0031224,GO:0044237,GO:0044425,GO:0045333,GO:0055114 - - - - - - - - - - Cytochrom_NNT,Cytochrom_c3_2 k59_81316_2 204669.Acid345_2713 1.72e-14 74.7 COG0484@1|root,COG2864@1|root,COG0484@2|Bacteria,COG2864@2|Bacteria,3Y6QW@57723|Acidobacteria 57723|Acidobacteria C Prokaryotic cytochrome b561 - - - - - - - - - - - - Cytochrom_c3_2,Ni_hydr_CYTB k59_1718668_1 272560.BPSL2563 2e-62 198.0 COG0194@1|root,COG0194@2|Bacteria,1MW92@1224|Proteobacteria,2VPCK@28216|Betaproteobacteria,1K0HE@119060|Burkholderiaceae 28216|Betaproteobacteria F Essential for recycling GMP and indirectly, cGMP gmk - 2.7.4.8 ko:K00942 ko00230,ko01100,map00230,map01100 M00050 R00332,R02090 RC00002 ko00000,ko00001,ko00002,ko01000 - - - Guanylate_kin k59_1434699_1 1286171.EAL2_808p00440 5.63e-31 126.0 COG5001@1|root,COG5001@2|Bacteria,1TP8V@1239|Firmicutes,247PX@186801|Clostridia,25ZN2@186806|Eubacteriaceae 186801|Clostridia T Putative diguanylate phosphodiesterase - - - - - - - - - - - - EAL,GGDEF,PAS,PAS_9,SBP_bac_3 k59_701694_1 635013.TherJR_0729 7.87e-25 105.0 COG1214@1|root,COG1214@2|Bacteria,1V4YX@1239|Firmicutes,24A0P@186801|Clostridia,261MZ@186807|Peptococcaceae 186801|Clostridia O PFAM Peptidase M22, glycoprotease yeaZ - - ko:K14742 - - - - ko00000,ko03016 - - - Acetyltransf_1,Peptidase_M22 k59_1605919_1 1198232.CYCME_1271 3.15e-40 146.0 COG1055@1|root,COG1055@2|Bacteria,1MUH8@1224|Proteobacteria,1RPSM@1236|Gammaproteobacteria,46042@72273|Thiotrichales 72273|Thiotrichales P Na H antiporter - - - - - - - - - - - - CitMHS k59_1434710_1 247633.GP2143_16771 3.4e-83 260.0 COG0471@1|root,COG0471@2|Bacteria,1MUSA@1224|Proteobacteria,1RPU5@1236|Gammaproteobacteria 1236|Gammaproteobacteria P COG0471 Di- and tricarboxylate transporters sdcS - - ko:K14445 - - - - ko00000,ko02000 2.A.47.1 - - Na_sulph_symp k59_474335_1 394.NGR_c05700 1.06e-113 351.0 COG3957@1|root,COG3957@2|Bacteria,1MVSE@1224|Proteobacteria,2TU2E@28211|Alphaproteobacteria,4B9N7@82115|Rhizobiaceae 28211|Alphaproteobacteria G Phosphoketolase xfp - 4.1.2.22,4.1.2.9 ko:K01621 ko00030,ko00710,ko01100,ko01120,map00030,map00710,map01100,map01120 - R00761,R01621 RC00032,RC00226 ko00000,ko00001,ko01000 - - - XFP,XFP_C,XFP_N k59_1605932_1 1197477.IA57_06825 1.15e-69 218.0 COG2177@1|root,COG2177@2|Bacteria,4NH05@976|Bacteroidetes,1HXFX@117743|Flavobacteriia 976|Bacteroidetes D Required for cell division and gliding motility ftsX GO:0005575,GO:0005618,GO:0005623,GO:0006928,GO:0008150,GO:0009274,GO:0009276,GO:0009605,GO:0009607,GO:0009615,GO:0009987,GO:0030312,GO:0030313,GO:0031975,GO:0040011,GO:0043207,GO:0044464,GO:0048870,GO:0050896,GO:0051179,GO:0051301,GO:0051674,GO:0051704,GO:0051707,GO:0071944,GO:0071976 - ko:K09811 ko02010,map02010 M00256 - - ko00000,ko00001,ko00002,ko02000,ko03036 3.A.1.140 - - FtsX k59_1605932_2 391596.PBAL39_02860 9.66e-35 123.0 COG1680@1|root,COG1680@2|Bacteria,4NEVS@976|Bacteroidetes 976|Bacteroidetes V COG1680 Beta-lactamase class C and other penicillin binding - - - - - - - - - - - - Beta-lactamase k59_1661762_1 316407.21238993 1.01e-52 170.0 COG3539@1|root,COG3539@2|Bacteria,1RJYB@1224|Proteobacteria,1S7ET@1236|Gammaproteobacteria,3XR7D@561|Escherichia 1236|Gammaproteobacteria NU Part of the yadCKLM-htrE-yadVN fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches yadL - - - - - - - - - - - Fimbrial k59_1661762_2 316407.21238994 5.78e-83 248.0 COG3539@1|root,COG3539@2|Bacteria,1N055@1224|Proteobacteria,1SBJ2@1236|Gammaproteobacteria,3XR2W@561|Escherichia 1236|Gammaproteobacteria NU Part of the yadCKLM-htrE-yadVN fimbrial operon. Could contribute to adhesion to various surfaces in specific environmental niches yadM GO:0007155,GO:0008150,GO:0022610 - - - - - - - - - - Fimbrial k59_192590_1 436308.Nmar_1794 2.19e-146 446.0 COG1933@1|root,arCOG04447@2157|Archaea,41SYW@651137|Thaumarchaeota 651137|Thaumarchaeota L Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase polC - 2.7.7.7 ko:K02322 ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030 M00264 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032 - - - PolC_DP2 k59_1434721_1 1144305.PMI02_02892 1.57e-63 203.0 COG1028@1|root,COG1028@2|Bacteria,1MU3W@1224|Proteobacteria,2TT5X@28211|Alphaproteobacteria,2K05I@204457|Sphingomonadales 204457|Sphingomonadales IQ Short-chain dehydrogenase reductase sdr - - - - - - - - - - - - adh_short_C2 k59_306995_1 323261.Noc_2093 2.51e-09 66.2 COG2931@1|root,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,1S479@1236|Gammaproteobacteria 1236|Gammaproteobacteria Q SMART Integrin alpha beta-propellor repeat protein - - 3.1.4.50 ko:K01127 ko00563,map00563 - R06623 - ko00000,ko00001,ko01000 - - - FG-GAP k59_81356_1 1121918.ARWE01000001_gene933 2.74e-37 139.0 COG1947@1|root,COG1947@2|Bacteria,1MVU3@1224|Proteobacteria,42RGS@68525|delta/epsilon subdivisions,2WNJR@28221|Deltaproteobacteria,43TCF@69541|Desulfuromonadales 28221|Deltaproteobacteria F Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol ispE GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0044237,GO:0050515 2.7.1.148 ko:K00919 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05634 RC00002,RC01439 ko00000,ko00001,ko00002,ko01000 - - - GHMP_kinases_C,GHMP_kinases_N k59_81356_2 667014.Thein_1529 3.61e-16 73.9 2EAFJ@1|root,334IY@2|Bacteria,2GHZR@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria S Domain of unknown function (DUF1844) - - - - - - - - - - - - DUF1844 k59_1041922_1 948106.AWZT01000023_gene3948 6.57e-62 202.0 COG3119@1|root,COG3119@2|Bacteria,1MUJH@1224|Proteobacteria,2VNDQ@28216|Betaproteobacteria,1K60X@119060|Burkholderiaceae 28216|Betaproteobacteria P Sulfatase - - 3.1.6.1,3.1.6.6 ko:K01130,ko:K01133 ko00140,ko00600,map00140,map00600 - R03980,R04856 RC00128,RC00231 ko00000,ko00001,ko01000 - - - Sulfatase,Sulfatase_C k59_1041922_2 1179778.PMM47T1_20673 4.78e-23 100.0 COG2885@1|root,COG2885@2|Bacteria,1RENP@1224|Proteobacteria,1S4IW@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Belongs to the ompA family oprF - - ko:K03286 - - - - ko00000,ko02000 1.B.6 - - OMP_b-brl,OmpA,TSP_3 k59_1041924_1 697282.Mettu_0785 6.59e-96 295.0 COG0129@1|root,COG0129@2|Bacteria,1MUTQ@1224|Proteobacteria,1RMP2@1236|Gammaproteobacteria,1XESA@135618|Methylococcales 135618|Methylococcales H Belongs to the IlvD Edd family ilvD - 4.2.1.9 ko:K01687 ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R01209,R04441,R05070 RC00468,RC01714 ko00000,ko00001,ko00002,ko01000 - - - ILVD_EDD k59_1210171_1 1122137.AQXF01000007_gene3565 4.64e-88 279.0 COG1523@1|root,COG1523@2|Bacteria,1MU19@1224|Proteobacteria,2TRVS@28211|Alphaproteobacteria 28211|Alphaproteobacteria G Belongs to the glycosyl hydrolase 13 family glgX - 3.2.1.196,3.2.1.68 ko:K01214,ko:K02438 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R02111,R09995,R11261 - ko00000,ko00001,ko00002,ko01000 - CBM48,GH13 - Alpha-amylase,CBM_48 k59_926571_1 485918.Cpin_4992 0.000991 47.0 COG1629@1|root,COG1629@2|Bacteria,COG4771@2|Bacteria,4NDXS@976|Bacteroidetes,1IV9Z@117747|Sphingobacteriia 976|Bacteroidetes P TonB-dependent receptor plug - - - - - - - - - - - - CarbopepD_reg_2,Plug,TonB_dep_Rec k59_81380_1 404589.Anae109_1793 4.89e-54 180.0 COG0861@1|root,COG0861@2|Bacteria,1MUNR@1224|Proteobacteria,42PJP@68525|delta/epsilon subdivisions,2WJI0@28221|Deltaproteobacteria,2YXVU@29|Myxococcales 28221|Deltaproteobacteria P Membrane protein, TerC - - - ko:K05794 - - - - ko00000 - - - TerC k59_1322306_1 1229909.NSED_09250 3.04e-63 198.0 arCOG08776@1|root,arCOG08776@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_1322306_2 1229909.NSED_09255 7.33e-39 130.0 arCOG08769@1|root,arCOG08769@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_644017_1 519989.ECTPHS_05621 5.46e-65 211.0 COG1706@1|root,COG1706@2|Bacteria,1MVKW@1224|Proteobacteria,1RMRB@1236|Gammaproteobacteria,1WVV3@135613|Chromatiales 135613|Chromatiales N Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation flgI - - ko:K02394 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - FlgI k59_363742_1 106370.Francci3_0692 3.7e-101 317.0 COG0173@1|root,COG0173@2|Bacteria,2GJHU@201174|Actinobacteria,4ERRC@85013|Frankiales 201174|Actinobacteria J Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) aspS - 6.1.1.12 ko:K01876 ko00970,map00970 M00359,M00360 R05577 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - GAD,tRNA-synt_2,tRNA_anti-codon k59_1096127_1 316407.85676385 1.18e-118 348.0 COG0477@1|root,COG2814@2|Bacteria,1MWWU@1224|Proteobacteria,1RN2I@1236|Gammaproteobacteria,3XQFD@561|Escherichia 1236|Gammaproteobacteria P sugar efflux transporter setB GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006950,GO:0007059,GO:0008150,GO:0008643,GO:0009987,GO:0015766,GO:0015767,GO:0015772,GO:0016020,GO:0016021,GO:0031224,GO:0033554,GO:0036447,GO:0036448,GO:0044425,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0051716,GO:0071702,GO:0071944 - ko:K03291 - - - - ko00000,ko02000 2.A.1.20 - iEC042_1314.EC042_2403,iECDH1ME8569_1439.ECDH1ME8569_0068 MFS_1 k59_644021_1 7739.XP_002609223.1 3.33e-18 88.6 COG1028@1|root,KOG1208@2759|Eukaryota,39QMQ@33154|Opisthokonta,3BJ9X@33208|Metazoa,3CUV9@33213|Bilateria,485RJ@7711|Chordata 33208|Metazoa Q Dehydrogenase reductase SDR family DHRSX GO:0003674,GO:0003824,GO:0005575,GO:0005576,GO:0008150,GO:0008152,GO:0009893,GO:0009894,GO:0009896,GO:0010506,GO:0010508,GO:0016491,GO:0019222,GO:0031323,GO:0031325,GO:0031329,GO:0031331,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0055114,GO:0065007 - ko:K11170 - - - - ko00000,ko01000 - - - adh_short k59_1605980_1 378806.STAUR_0326 3.66e-94 306.0 COG0436@1|root,COG2890@1|root,COG0436@2|Bacteria,COG2890@2|Bacteria,1P71G@1224|Proteobacteria 1224|Proteobacteria EJ Aminotransferase - - - - - - - - - - - - Aminotran_1_2 k59_1549800_1 296591.Bpro_4835 8.24e-09 56.2 COG3439@1|root,COG3439@2|Bacteria,1MZ38@1224|Proteobacteria,2VVUF@28216|Betaproteobacteria 28216|Betaproteobacteria V Domain of unknown function DUF302 - - - - - - - - - - - - DUF302 k59_136991_1 1120950.KB892789_gene55 3.25e-22 90.9 COG2030@1|root,COG2030@2|Bacteria,2GN4R@201174|Actinobacteria,4DRWF@85009|Propionibacteriales 201174|Actinobacteria I N-terminal half of MaoC dehydratase - - - - - - - - - - - - MaoC_dehydratas k59_1264992_1 1433126.BN938_0412 1.44e-07 56.2 COG3415@1|root,COG3415@2|Bacteria,4NUCM@976|Bacteroidetes 976|Bacteroidetes L Winged helix-turn helix - - - - - - - - - - - - HTH_32,HTH_33 k59_872237_1 243233.MCA3000 2.92e-88 283.0 COG2609@1|root,COG2609@2|Bacteria,1MV21@1224|Proteobacteria,1RN6K@1236|Gammaproteobacteria,1XDXS@135618|Methylococcales 135618|Methylococcales C Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) - - 1.2.4.1 ko:K00163 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200 M00307 R00014,R00209,R01699,R03270 RC00004,RC00027,RC00627,RC02742,RC02744,RC02882 br01601,ko00000,ko00001,ko00002,ko01000 - - - Transketolase_N k59_474387_1 1121946.AUAX01000004_gene928 4.96e-26 105.0 COG0454@1|root,COG0456@2|Bacteria,2HW3C@201174|Actinobacteria,4DI9Y@85008|Micromonosporales 201174|Actinobacteria K FR47-like protein - - - - - - - - - - - - Acetyltransf_1 k59_474387_3 272624.lpg1167 0.000505 41.6 COG1666@1|root,COG1666@2|Bacteria,1RDTF@1224|Proteobacteria,1S3RU@1236|Gammaproteobacteria,1JCDP@118969|Legionellales 118969|Legionellales S Protein of unknown function (DUF520) yajQ - - ko:K09767 - - - - ko00000 - - - DUF520 k59_982147_1 436308.Nmar_0424 1.57e-99 294.0 COG1208@1|root,arCOG00663@2157|Archaea 2157|Archaea M PFAM Nucleotidyl transferase - - 2.6.1.37,2.7.7.13 ko:K00966,ko:K03430 ko00051,ko00440,ko00520,ko01100,ko01110,ko01120,map00051,map00440,map00520,map01100,map01110,map01120 M00114,M00361,M00362 R00885,R04152 RC00002,RC00008,RC00062 ko00000,ko00001,ko00002,ko01000,ko01007 - - - NTP_transferase k59_1210219_1 1385517.N800_06130 2.69e-81 254.0 COG0697@1|root,COG0697@2|Bacteria,1N4MD@1224|Proteobacteria,1SZQ5@1236|Gammaproteobacteria,1X4YA@135614|Xanthomonadales 135614|Xanthomonadales EG Permeases of the drug metabolite transporter (DMT) superfamily - - - - - - - - - - - - EamA k59_1210219_2 1283300.ATXB01000001_gene2068 1.43e-90 275.0 COG1611@1|root,COG1611@2|Bacteria,1MU6N@1224|Proteobacteria,1S032@1236|Gammaproteobacteria,1XEKP@135618|Methylococcales 135618|Methylococcales S Possible lysine decarboxylase - - 3.2.2.10 ko:K06966 ko00230,ko00240,map00230,map00240 - R00182,R00510 RC00063,RC00318 ko00000,ko00001,ko01000 - - - Lysine_decarbox k59_137007_2 1545915.JROG01000004_gene2269 1.19e-66 213.0 COG3828@1|root,COG3828@2|Bacteria,1RF65@1224|Proteobacteria,2UA54@28211|Alphaproteobacteria,2K450@204457|Sphingomonadales 204457|Sphingomonadales S Trehalose utilisation - - - ko:K09992 - - - - ko00000 - - - ThuA k59_1493553_1 1353276.JADR01000001_gene712 5.92e-79 242.0 COG1477@1|root,COG1477@2|Bacteria,4NGEK@976|Bacteroidetes,1HWM7@117743|Flavobacteriia 976|Bacteroidetes H Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein apbE - 2.7.1.180 ko:K03734 - - - - ko00000,ko01000 - - - ApbE k59_1493553_2 1131812.JQMS01000001_gene2554 1.07e-22 89.0 2E4IE@1|root,32ZDH@2|Bacteria,4NUR6@976|Bacteroidetes,1I59Y@117743|Flavobacteriia,2NXBM@237|Flavobacterium 976|Bacteroidetes S Domain of unknown function (DUF4266) - - - - - - - - - - - - DUF4266 k59_1265005_1 1122137.AQXF01000003_gene2148 6.24e-41 148.0 COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,2TR3X@28211|Alphaproteobacteria 28211|Alphaproteobacteria S COG0488 ATPase components of ABC transporters with duplicated ATPase domains uup GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0008150,GO:0009314,GO:0009628,GO:0010528,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019219,GO:0019222,GO:0031323,GO:0044424,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051171,GO:0060255,GO:0065007,GO:0070894,GO:0071944,GO:0080090,GO:0097159,GO:1901363 - ko:K15738 - - - - ko00000,ko02000 3.A.1.120.6 - - ABC_tran,ABC_tran_CTD k59_1097089_1 349521.HCH_03648 2.06e-88 280.0 COG0480@1|root,COG0480@2|Bacteria,1MVVY@1224|Proteobacteria,1RYCE@1236|Gammaproteobacteria,1XMXM@135619|Oceanospirillales 135619|Oceanospirillales J Elongation factor G, domain IV - - - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU k59_1494751_1 159087.Daro_1776 6.92e-53 173.0 COG0479@1|root,COG0479@2|Bacteria,1MVHS@1224|Proteobacteria,2VIKC@28216|Betaproteobacteria,2KY25@206389|Rhodocyclales 206389|Rhodocyclales C 2Fe-2S iron-sulfur cluster binding domain - - 1.3.5.4 ko:K00245 ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020 M00009,M00011,M00150,M00173 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 - - - Fer2_3,Fer4_8 k59_1154128_1 1122137.AQXF01000002_gene121 6.56e-27 108.0 COG1008@1|root,COG1008@2|Bacteria,1MV7V@1224|Proteobacteria,2TSNK@28211|Alphaproteobacteria 28211|Alphaproteobacteria C NADH ubiquinone oxidoreductase subunit 4 (chain M) nuoM GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 1.6.5.3 ko:K00342 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q5_N,Proton_antipo_M k59_1154128_2 1122137.AQXF01000002_gene122 2.89e-164 472.0 COG1007@1|root,COG1007@2|Bacteria,1MV56@1224|Proteobacteria,2TQMX@28211|Alphaproteobacteria 28211|Alphaproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoN - 1.6.5.3 ko:K00343 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Proton_antipo_M k59_82601_1 67593.Physo128249 3.61e-06 49.3 COG0613@1|root,2QUA5@2759|Eukaryota,3QFBB@4776|Peronosporales 4776|Peronosporales S DNA polymerase alpha chain like domain - - 3.1.3.97 ko:K07053 - - R00188,R11188 RC00078 ko00000,ko01000 - - - PHP k59_82601_2 765912.Thimo_0969 7.78e-10 59.3 COG2917@1|root,COG2917@2|Bacteria,1NWIZ@1224|Proteobacteria,1RQAB@1236|Gammaproteobacteria,1WX92@135613|Chromatiales 135613|Chromatiales D probably involved in intracellular septation - - - ko:K06190 - - - - ko00000 - - - IspA k59_419778_2 1229909.NSED_08055 1.25e-51 164.0 arCOG08127@1|root,arCOG08127@2157|Archaea,41T5Y@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_419778_3 751944.HALDL1_10105 1.94e-26 109.0 arCOG11838@1|root,arCOG11838@2157|Archaea 2157|Archaea S CHRD domain - - - - - - - - - - - - CHRD,Ferritin_2 k59_138179_1 1349767.GJA_730 1.47e-13 70.9 COG4191@1|root,COG4191@2|Bacteria,1QU7R@1224|Proteobacteria,2VICU@28216|Betaproteobacteria,473E9@75682|Oxalobacteraceae 28216|Betaproteobacteria T His Kinase A (phosphoacceptor) domain pilS - 2.7.13.3 ko:K02668,ko:K10125 ko02020,map02020 M00501,M00504 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 - - - HATPase_c,HisKA,PAS_8 k59_138179_2 522306.CAP2UW1_0768 2.33e-66 217.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2VHSB@28216|Betaproteobacteria,1KQCV@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria T Two component, sigma54 specific, transcriptional regulator, Fis family pilR - - ko:K02667 ko02020,map02020 M00501 - - ko00000,ko00001,ko00002,ko02022,ko02035 - - - HTH_8,Response_reg,Sigma54_activat k59_873409_1 1346791.M529_10345 1.81e-37 144.0 COG1629@1|root,COG4771@2|Bacteria,1QURZ@1224|Proteobacteria,2U2N2@28211|Alphaproteobacteria,2KEB8@204457|Sphingomonadales 204457|Sphingomonadales P TonB dependent receptor - - - - - - - - - - - - Plug,TonB_dep_Rec k59_250505_2 1238182.C882_2899 1e-80 250.0 COG0381@1|root,COG0381@2|Bacteria,1QUYI@1224|Proteobacteria,2TWD4@28211|Alphaproteobacteria,2JPB7@204441|Rhodospirillales 204441|Rhodospirillales M Belongs to the UDP-N-acetylglucosamine 2-epimerase family - - 5.1.3.14 ko:K01791 ko00520,ko01100,ko05111,map00520,map01100,map05111 M00362 R00420 RC00290 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Epimerase_2 k59_1043173_1 1123073.KB899241_gene2027 3.54e-32 130.0 COG1361@1|root,COG1361@2|Bacteria,1QCRB@1224|Proteobacteria,1T8HR@1236|Gammaproteobacteria,1XAR7@135614|Xanthomonadales 135614|Xanthomonadales M Conserved repeat domain - - - - - - - - - - - - - k59_1265846_1 861299.J421_3399 1.06e-80 250.0 COG0686@1|root,COG0686@2|Bacteria,1ZSSE@142182|Gemmatimonadetes 142182|Gemmatimonadetes C Alanine dehydrogenase/PNT, N-terminal domain - - 1.4.1.1 ko:K00259 ko00250,ko00430,ko01100,map00250,map00430,map01100 - R00396 RC00008 ko00000,ko00001,ko01000 - - - AlaDh_PNT_C,AlaDh_PNT_N k59_308220_1 983545.Glaag_2927 2.15e-26 113.0 COG1629@1|root,COG4771@2|Bacteria,1MU9K@1224|Proteobacteria,1RMTG@1236|Gammaproteobacteria,4651V@72275|Alteromonadaceae 1236|Gammaproteobacteria P COG1629 Outer membrane receptor proteins, mostly Fe transport - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_138195_1 1121875.KB907550_gene636 1.28e-42 157.0 COG2015@1|root,COG2015@2|Bacteria,4NJE2@976|Bacteroidetes 976|Bacteroidetes Q Alkyl sulfatase dimerisation - - - - - - - - - - - - Alkyl_sulf_C,Alkyl_sulf_dimr,Lactamase_B k59_365038_1 1552758.NC00_15460 1.87e-32 130.0 COG1629@1|root,COG4771@2|Bacteria,1MX42@1224|Proteobacteria,1RQ2K@1236|Gammaproteobacteria,1X35F@135614|Xanthomonadales 135614|Xanthomonadales P receptor - - - ko:K16087 - - - - ko00000,ko02000 1.B.14.2 - - Plug,TonB_dep_Rec k59_475242_1 243233.MCA0444 3.73e-35 144.0 COG1858@1|root,COG1858@2|Bacteria,1RC4D@1224|Proteobacteria,1SJKT@1236|Gammaproteobacteria,1XFYK@135618|Methylococcales 135618|Methylococcales C cytochrome C peroxidase - - - - - - - - - - - - - k59_983030_1 1122207.MUS1_14190 1.2e-77 245.0 COG0148@1|root,COG0148@2|Bacteria,1MU1N@1224|Proteobacteria,1RNQA@1236|Gammaproteobacteria,1XHYF@135619|Oceanospirillales 135619|Oceanospirillales G Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis eno - 4.2.1.11 ko:K01689 ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066 M00001,M00002,M00003,M00346,M00394 R00658 RC00349 ko00000,ko00001,ko00002,ko01000,ko03019,ko04147 - - - Enolase_C,Enolase_N k59_1265881_2 1379270.AUXF01000002_gene1169 1.33e-48 161.0 COG0494@1|root,COG0494@2|Bacteria,1ZTQ5@142182|Gemmatimonadetes 142182|Gemmatimonadetes L NUDIX domain - - 3.6.1.13 ko:K01515 ko00230,map00230 - R01054 RC00002 ko00000,ko00001,ko01000 - - - NUDIX k59_1163247_1 443152.MDG893_04457 3.39e-117 364.0 COG0784@1|root,COG4191@1|root,COG0784@2|Bacteria,COG4191@2|Bacteria,1QTVB@1224|Proteobacteria,1RYDJ@1236|Gammaproteobacteria,464AX@72275|Alteromonadaceae 1236|Gammaproteobacteria T COG0642 Signal transduction histidine kinase pedS1 - 2.7.13.3 ko:K20975 ko02020,ko02025,map02020,map02025 M00820 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA,PAS_4,PAS_7,PAS_8,Response_reg k59_1163247_2 443152.MDG893_04452 1.75e-29 112.0 COG2197@1|root,COG2197@2|Bacteria,1PXTY@1224|Proteobacteria,1RMPW@1236|Gammaproteobacteria,466JI@72275|Alteromonadaceae 1236|Gammaproteobacteria K COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain agmR - - ko:K07684 ko02020,map02020 M00471 - - ko00000,ko00001,ko00002,ko02022 - - - GerE,Response_reg k59_1163253_1 981383.AEWH01000004_gene3360 4.16e-51 181.0 COG0532@1|root,COG0532@2|Bacteria,1TPAI@1239|Firmicutes,4HA8S@91061|Bacilli 91061|Bacilli J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex infB GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - ko:K02519 - - - - ko00000,ko03012,ko03029 - - - GTP_EFTU,IF-2,IF2_N k59_482269_1 1211777.BN77_3483 1.78e-44 152.0 COG3963@1|root,COG3963@2|Bacteria,1N1KB@1224|Proteobacteria,2U646@28211|Alphaproteobacteria,4B7GX@82115|Rhizobiaceae 28211|Alphaproteobacteria I Methyltransferase domain - - - - - - - - - - - - Methyltransf_25,RrnaAD k59_482269_2 1122207.MUS1_13095 1.55e-05 46.6 COG2204@1|root,COG2204@2|Bacteria 2|Bacteria T phosphorelay signal transduction system fhlA - - ko:K03413,ko:K13589 ko02020,ko02030,ko04112,map02020,map02030,map04112 M00506,M00512 - - ko00000,ko00001,ko00002,ko02022,ko02035 - - - HTH_8,Response_reg,Sigma54_activat k59_260271_1 1167006.UWK_00679 1.48e-95 291.0 COG0019@1|root,COG0019@2|Bacteria,1MUA6@1224|Proteobacteria,42KZH@68525|delta/epsilon subdivisions,2WIRM@28221|Deltaproteobacteria,2MJBU@213118|Desulfobacterales 28221|Deltaproteobacteria E Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine lysA - 4.1.1.20 ko:K01586 ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R00451 RC00299 ko00000,ko00001,ko00002,ko01000 - - - Orn_Arg_deC_N,Orn_DAP_Arg_deC k59_1163255_1 1094980.Mpsy_1009 3.41e-12 73.2 COG0086@1|root,arCOG04256@2157|Archaea,2XTJ6@28890|Euryarchaeota,2N927@224756|Methanomicrobia 224756|Methanomicrobia K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoA2 - 2.7.7.6 ko:K03042 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00184 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021 - - - RNA_pol_Rpb1_5 k59_1051966_1 1122137.AQXF01000004_gene1798 8.65e-33 131.0 COG2911@1|root,COG2931@1|root,COG2911@2|Bacteria,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,2TRVY@28211|Alphaproteobacteria 28211|Alphaproteobacteria Q COG2931 RTX toxins and related Ca2 -binding proteins - - - ko:K07004 - - - - ko00000 - - - Calx-beta,DUF4347,HemolysinCabind,P_proprotein,Peptidase_M10,Peptidase_M10_C,Peptidase_S8 k59_1330107_1 85643.Tmz1t_3285 1.82e-62 201.0 COG1136@1|root,COG1136@2|Bacteria,1MU45@1224|Proteobacteria,2VQWS@28216|Betaproteobacteria,2KU68@206389|Rhodocyclales 206389|Rhodocyclales V ATP-binding cassette (ABC) transporters form a large family of proteins responsible for translocation of a variety of compounds across biological membranes. They are composed of two transmembrane domains responsible for binding and transport and two nucleotide-binding domains responsible for coupling the energy of ATP hydrolysis to conformational changes in the TMDs - - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_1330107_2 911045.PSE_3322 2.22e-05 52.8 COG0577@1|root,COG0577@2|Bacteria,1MWBK@1224|Proteobacteria,2TUJD@28211|Alphaproteobacteria 28211|Alphaproteobacteria V FtsX-like permease family - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_1391618_1 857087.Metme_2457 1.43e-70 220.0 COG1733@1|root,COG1733@2|Bacteria,1PGWN@1224|Proteobacteria,1SXVP@1236|Gammaproteobacteria,1XGTB@135618|Methylococcales 135618|Methylococcales K HxlR-like helix-turn-helix - - - - - - - - - - - - HxlR k59_1443024_1 1229780.BN381_30048 3.55e-39 142.0 COG0226@1|root,COG0226@2|Bacteria,2GMY1@201174|Actinobacteria 201174|Actinobacteria P phosphate binding protein pstS - - ko:K02040 ko02010,ko02020,ko05152,map02010,map02020,map05152 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - HSP70,PBP_like,PBP_like_2 k59_1780379_1 981384.AEYW01000012_gene844 5.75e-81 250.0 COG3618@1|root,COG3618@2|Bacteria,1P5PT@1224|Proteobacteria,2U3BR@28211|Alphaproteobacteria,4NBQZ@97050|Ruegeria 28211|Alphaproteobacteria S Amidohydrolase - - - ko:K07046 ko00051,ko01120,map00051,map01120 - R10689 RC00537 ko00000,ko00001,ko01000 - - - Amidohydro_2 k59_1391625_1 1502724.FF80_04099 2.25e-20 90.1 COG2064@1|root,COG2064@2|Bacteria,1MWAZ@1224|Proteobacteria,2TSFA@28211|Alphaproteobacteria,3N6E6@45401|Hyphomicrobiaceae 28211|Alphaproteobacteria NU Type II secretion system tadC - - ko:K12511 - - - - ko00000,ko02044 - - - T2SSF k59_1051976_1 1249627.D779_3353 1.54e-82 273.0 COG0086@1|root,COG0086@2|Bacteria,1MU3M@1224|Proteobacteria,1RPYH@1236|Gammaproteobacteria,1WVVI@135613|Chromatiales 135613|Chromatiales K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoC - 2.7.7.6 ko:K03046 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5 k59_1615449_1 1278309.KB907111_gene3379 1.03e-65 218.0 COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,1RR14@1236|Gammaproteobacteria,1XIX7@135619|Oceanospirillales 135619|Oceanospirillales I COG0365 Acyl-coenzyme A synthetases AMP-(fatty) acid ligases prpE - 6.2.1.17 ko:K01908 ko00640,ko01100,map00640,map01100 - R00926,R01354 RC00004,RC00043,RC00070,RC02816 ko00000,ko00001,ko01000,ko01004 - - - ACAS_N,AMP-binding,AMP-binding_C k59_1615449_2 1535422.ND16A_2599 4.86e-31 111.0 COG4327@1|root,COG4327@2|Bacteria,1N0TK@1224|Proteobacteria,1S8V9@1236|Gammaproteobacteria,2Q74U@267889|Colwelliaceae 1236|Gammaproteobacteria S Domain of unknown function (DUF4212) - - - - - - - - - - - - DUF4212 k59_1615449_3 314285.KT71_17291 1.4e-09 57.8 COG4147@1|root,COG4147@2|Bacteria,1MVJ8@1224|Proteobacteria,1RN0R@1236|Gammaproteobacteria,1J589@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family actP - - ko:K14393 - - - - ko00000,ko02000 2.A.21.7 - - SSF k59_1220014_1 640081.Dsui_2375 5.2e-41 150.0 COG0443@1|root,COG0443@2|Bacteria,1MVQI@1224|Proteobacteria,2VHGV@28216|Betaproteobacteria,2KUV2@206389|Rhodocyclales 206389|Rhodocyclales O Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB hscA - - ko:K04044 - - - - ko00000,ko03110 1.A.33 - - HSP70 k59_712932_2 279238.Saro_0679 2.72e-86 265.0 COG1565@1|root,COG1565@2|Bacteria,1N3CJ@1224|Proteobacteria,2TRHW@28211|Alphaproteobacteria,2K21E@204457|Sphingomonadales 204457|Sphingomonadales M Putative S-adenosyl-L-methionine-dependent methyltransferase - - - ko:K18164 ko04714,map04714 - - - ko00000,ko00001,ko03029 - - - Methyltransf_28 k59_1163284_1 105559.Nwat_2312 3.52e-65 222.0 COG2911@1|root,COG2911@2|Bacteria,1MW9V@1224|Proteobacteria,1S3FX@1236|Gammaproteobacteria,1X0GV@135613|Chromatiales 135613|Chromatiales S Protein conserved in bacteria - - - - - - - - - - - - - k59_1780389_1 314287.GB2207_11783 1.69e-113 338.0 COG2270@1|root,COG2270@2|Bacteria,1QUVA@1224|Proteobacteria,1T226@1236|Gammaproteobacteria,1JC10@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S COG0477 Permeases of the major facilitator superfamily Z012_03780 - - ko:K08218 ko01501,map01501 M00628 - - ko00000,ko00001,ko00002,ko02000 2.A.1.25 - - MFS_1 k59_35385_1 1279017.AQYJ01000024_gene861 1.65e-104 328.0 COG0532@1|root,COG0532@2|Bacteria,1MV26@1224|Proteobacteria,1RM9X@1236|Gammaproteobacteria,46433@72275|Alteromonadaceae 1236|Gammaproteobacteria J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex infB GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003676,GO:0003723,GO:0003743,GO:0003824,GO:0003924,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006413,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019538,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034641,GO:0034645,GO:0036094,GO:0043021,GO:0043024,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0097159,GO:0097216,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - ko:K02519 - - - - ko00000,ko03012,ko03029 - - - GTP_EFTU,GTP_EFTU_D2,IF-2,IF2_N,IF2_assoc k59_599859_1 1172181.KB911725_gene4189 1.53e-16 85.5 COG1132@1|root,COG1132@2|Bacteria,2GITR@201174|Actinobacteria 201174|Actinobacteria V ABC transporter - - - ko:K06147 - - - - ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran k59_934705_2 1122194.AUHU01000009_gene3156 1.74e-28 110.0 COG0266@1|root,COG0266@2|Bacteria,1MVM5@1224|Proteobacteria,1RP3J@1236|Gammaproteobacteria,464SQ@72275|Alteromonadaceae 1236|Gammaproteobacteria L Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates fpg GO:0000702,GO:0000703,GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003824,GO:0003906,GO:0004518,GO:0004519,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006285,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008270,GO:0008534,GO:0009987,GO:0016787,GO:0016788,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034641,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901363 3.2.2.23,4.2.99.18 ko:K10563 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - Fapy_DNA_glyco,H2TH,zf-FPG_IleRS k59_91349_1 2340.JV46_04210 5.69e-57 178.0 COG0335@1|root,COG0335@2|Bacteria,1RH3A@1224|Proteobacteria,1S5XX@1236|Gammaproteobacteria,1J65P@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site rplS GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070180,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02884 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L19 k59_91349_2 187272.Mlg_0886 3.61e-71 222.0 COG0336@1|root,COG0336@2|Bacteria,1MUN1@1224|Proteobacteria,1RMWC@1236|Gammaproteobacteria,1WWK4@135613|Chromatiales 135613|Chromatiales J Belongs to the RNA methyltransferase TrmD family trmD - 2.1.1.228 ko:K00554 - - R00597 RC00003,RC00334 ko00000,ko01000,ko03016 - - - tRNA_m1G_MT k59_1273263_1 985255.APHJ01000031_gene2787 3.52e-51 177.0 COG1249@1|root,COG1249@2|Bacteria,4NDVC@976|Bacteroidetes,1HWVS@117743|Flavobacteriia,2P64Y@244698|Gillisia 976|Bacteroidetes C L-lysine 6-monooxygenase (NADPH-requiring) lpdA - 1.8.1.4 ko:K00382 ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00036,M00307,M00532 R00209,R01221,R01698,R03815,R07618,R08549 RC00004,RC00022,RC00583,RC02742,RC02833,RC02834 br01601,ko00000,ko00001,ko00002,ko01000,ko04147 - - - Pyr_redox_2,Pyr_redox_dim k59_1273263_2 1255043.TVNIR_1956 1.05e-76 233.0 COG0377@1|root,COG0377@2|Bacteria,1MUI2@1224|Proteobacteria,1RP4R@1236|Gammaproteobacteria,1WW6I@135613|Chromatiales 135613|Chromatiales C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient - - 1.6.5.3 ko:K00331 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q6 k59_1273263_3 1146883.BLASA_3825 7.63e-46 158.0 COG1183@1|root,COG1183@2|Bacteria,2IC3M@201174|Actinobacteria 201174|Actinobacteria I phosphatidylcholine synthase pcs - 2.7.8.24 ko:K01004 ko00564,ko01110,map00564,map01110 - R05794 RC00002,RC00017,RC02795 ko00000,ko00001,ko01000 - - - CDP-OH_P_transf k59_823038_1 1269813.ATUL01000008_gene1534 4.93e-76 237.0 COG2890@1|root,COG2890@2|Bacteria,1MX8Q@1224|Proteobacteria,1RPHQ@1236|Gammaproteobacteria,1WWX2@135613|Chromatiales 135613|Chromatiales J Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue prmB - 2.1.1.298 ko:K07320 - - R10806 RC00003,RC03279 ko00000,ko01000,ko03009 - - - MTS k59_36986_2 1229909.NSED_02335 3.06e-99 292.0 arCOG07871@1|root,arCOG07871@2157|Archaea,41T28@651137|Thaumarchaeota 651137|Thaumarchaeota L COG1061 DNA or RNA helicases of superfamily II - - - - - - - - - - - - - k59_991432_1 316407.85676398 1.46e-148 421.0 COG3645@1|root,COG3645@2|Bacteria,1MVMT@1224|Proteobacteria,1RYM2@1236|Gammaproteobacteria 1236|Gammaproteobacteria S DNA-damage-inducible protein d dinD GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0050896,GO:0051716,GO:0071496 - ko:K14623 - - - - ko00000,ko03400 - - - Bro-N k59_204244_1 1265502.KB905972_gene1343 3.22e-52 179.0 COG0421@1|root,COG1586@1|root,COG0421@2|Bacteria,COG1586@2|Bacteria,1MVV5@1224|Proteobacteria,2WGFP@28216|Betaproteobacteria,4ACQW@80864|Comamonadaceae 28216|Betaproteobacteria H Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine speE - 2.5.1.16 ko:K00797 ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100 M00034,M00133 R01920,R02869,R08359 RC00021,RC00053 ko00000,ko00001,ko00002,ko01000 - - - AdoMet_dc,Spermine_synt_N,Spermine_synth k59_1393270_1 395494.Galf_2791 4.56e-30 111.0 COG0818@1|root,COG0818@2|Bacteria,1MZ3Q@1224|Proteobacteria,2VU5Y@28216|Betaproteobacteria,44WG1@713636|Nitrosomonadales 28216|Betaproteobacteria M Recycling of diacylglycerol produced during the turnover of membrane phospholipid - - 2.7.1.107 ko:K00901 ko00561,ko00564,ko01100,ko01110,ko04070,ko04072,ko05231,map00561,map00564,map01100,map01110,map04070,map04072,map05231 - R02240 RC00002,RC00017 ko00000,ko00001,ko01000 - - - DAGK_prokar k59_1393270_2 498211.CJA_0524 5.39e-17 82.8 COG3152@1|root,COG3152@2|Bacteria,1N85G@1224|Proteobacteria,1SCMI@1236|Gammaproteobacteria,1FH9H@10|Cellvibrio 1236|Gammaproteobacteria S Membrane - - - - - - - - - - - - - k59_1393270_3 349521.HCH_05041 1.49e-09 59.3 COG2840@1|root,COG2840@2|Bacteria,1RH34@1224|Proteobacteria,1S6B5@1236|Gammaproteobacteria,1XK3Q@135619|Oceanospirillales 135619|Oceanospirillales S protein conserved in bacteria - - - - - - - - - - - - Smr k59_1616655_1 686340.Metal_0120 5.23e-52 183.0 COG0457@1|root,COG2304@1|root,COG0457@2|Bacteria,COG2304@2|Bacteria,1MW51@1224|Proteobacteria,1RMD3@1236|Gammaproteobacteria,1XEC7@135618|Methylococcales 135618|Methylococcales S von Willebrand factor, type A - - - ko:K07114 - - - - ko00000,ko02000 1.A.13.2.2,1.A.13.2.3 - - TPR_1,TPR_2,VWA_2 k59_765857_1 246197.MXAN_4128 2.88e-61 203.0 COG2433@1|root,COG2433@2|Bacteria,1RE5Q@1224|Proteobacteria,42WSA@68525|delta/epsilon subdivisions,2WRPQ@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Transposase IS66 family - - - ko:K07484 - - - - ko00000 - - - DDE_Tnp_IS66,zf-IS66 k59_1221132_2 1131814.JAFO01000001_gene2083 9.68e-15 79.0 COG0507@1|root,COG5362@1|root,COG0507@2|Bacteria,COG5362@2|Bacteria,1R90H@1224|Proteobacteria,2U236@28211|Alphaproteobacteria 28211|Alphaproteobacteria L TIGRFAM Phage - - - - - - - - - - - - Terminase_6 k59_714578_2 118168.MC7420_456 7.12e-09 56.2 COG1249@1|root,COG1249@2|Bacteria,1G198@1117|Cyanobacteria,1H7PH@1150|Oscillatoriales 1117|Cyanobacteria C Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase merA - - - - - - - - - - - Pyr_redox_2,Pyr_redox_dim,SNARE_assoc k59_1164860_1 472759.Nhal_2237 7.52e-25 101.0 COG0711@1|root,COG0712@1|root,COG0711@2|Bacteria,COG0712@2|Bacteria,1R6C0@1224|Proteobacteria,1S4NA@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) - - - ko:K02109 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt_B,OSCP k59_1164860_2 1131553.JIBI01000039_gene1942 7.05e-22 95.1 COG0056@1|root,COG0056@2|Bacteria,1MVHM@1224|Proteobacteria,2VPGJ@28216|Betaproteobacteria,3728R@32003|Nitrosomonadales 28216|Betaproteobacteria F Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit atpA2 - 3.6.3.14 ko:K02111 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - - ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N k59_935919_1 438753.AZC_3496 9.75e-45 152.0 COG0503@1|root,COG0503@2|Bacteria,1MVZ6@1224|Proteobacteria,2TV7J@28211|Alphaproteobacteria,3F0J0@335928|Xanthobacteraceae 28211|Alphaproteobacteria F Phosphoribosyl transferase domain apt - 2.4.2.7 ko:K00759 ko00230,ko01100,map00230,map01100 - R00190,R01229,R04378 RC00063 ko00000,ko00001,ko01000,ko04147 - - - Pribosyltran k59_935919_2 1206725.BAFU01000086_gene4555 1.75e-18 91.7 COG1023@1|root,COG1023@2|Bacteria,2I2DH@201174|Actinobacteria,4FX34@85025|Nocardiaceae 201174|Actinobacteria G Protein involved in phosphogluconate dehydrogenase (decarboxylating) activity, 3-hydroxyisobutyrate dehydrogenase activity, NADP binding, valine metabolism, pentose-phosphate shunt, oxidative branch and D-gluconate metabolism gnd2 - 1.1.1.343,1.1.1.44 ko:K00033 ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00480,map01100,map01110,map01120,map01130,map01200 M00004,M00006 R01528,R10221 RC00001,RC00539 ko00000,ko00001,ko00002,ko01000 - - iNJ661.Rv1122 6PGD,NAD_binding_2 k59_935922_1 1123508.JH636440_gene1973 4.01e-31 117.0 COG1595@1|root,COG1595@2|Bacteria,2J0GI@203682|Planctomycetes 203682|Planctomycetes K Sigma-70, region 4 - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 k59_261925_1 1267533.KB906736_gene1378 1.29e-35 138.0 COG0855@1|root,COG0855@2|Bacteria,3Y2YI@57723|Acidobacteria,2JIKB@204432|Acidobacteriia 204432|Acidobacteriia P Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) ppk - 2.7.4.1 ko:K00937 ko00190,ko03018,map00190,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - PP_kinase,PP_kinase_C,PP_kinase_N k59_935923_1 1121877.JQKF01000003_gene1462 3.78e-96 298.0 COG0129@1|root,COG0129@2|Bacteria,2GJIJ@201174|Actinobacteria,4CMQ6@84992|Acidimicrobiia 84992|Acidimicrobiia H Dehydratase family ilvD - 4.2.1.9 ko:K01687 ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R01209,R04441,R05070 RC00468,RC01714 ko00000,ko00001,ko00002,ko01000 - - - ILVD_EDD k59_601530_1 1123037.AUDE01000013_gene567 2.26e-91 273.0 COG0726@1|root,COG0726@2|Bacteria,4NM7D@976|Bacteroidetes,1I1F1@117743|Flavobacteriia 976|Bacteroidetes G polysaccharide deacetylase pgdA_1 - - - - - - - - - - - Polysacc_deac_1 k59_261930_1 1449063.JMLS01000004_gene2735 1.1e-10 67.4 COG0841@1|root,COG0841@2|Bacteria,1TQ03@1239|Firmicutes,4HAFP@91061|Bacilli,26SD1@186822|Paenibacillaceae 91061|Bacilli V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family acrB1 - - ko:K03296 - - - - ko00000 2.A.6.2 - - ACR_tran k59_1164875_1 667014.Thein_0579 3.67e-29 118.0 COG0317@1|root,COG0317@2|Bacteria,2GHKR@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance - - 2.7.6.5 ko:K00951 ko00230,map00230 - R00429 RC00002,RC00078 ko00000,ko00001,ko01000 - - - ACT_4,HD_4,RelA_SpoT,TGS k59_1164875_2 756272.Plabr_3964 5.86e-27 107.0 COG0463@1|root,COG0463@2|Bacteria,2J550@203682|Planctomycetes 203682|Planctomycetes M PFAM Glycosyl transferase family 2 - - - - - - - - - - - - Glycos_transf_2 k59_1563681_2 1137281.D778_00891 5.42e-93 278.0 COG0253@1|root,COG0253@2|Bacteria,4NF26@976|Bacteroidetes,1HY3U@117743|Flavobacteriia 976|Bacteroidetes E Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan dapF GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008837,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016853,GO:0016854,GO:0016855,GO:0019752,GO:0036361,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0047661,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.1.1.7 ko:K01778 ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00527 R02735 RC00302 ko00000,ko00001,ko00002,ko01000 - - - DAP_epimerase k59_261934_1 316407.85676120 9.13e-55 188.0 COG0460@1|root,COG0527@1|root,COG0460@2|Bacteria,COG0527@2|Bacteria,1MW3H@1224|Proteobacteria,1RN1G@1236|Gammaproteobacteria,3XPCP@561|Escherichia 1236|Gammaproteobacteria E Homoserine dehydrogenase II metL GO:0003674,GO:0003824,GO:0004072,GO:0004412,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006553,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009070,GO:0009085,GO:0009089,GO:0009090,GO:0009092,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016491,GO:0016614,GO:0016616,GO:0016740,GO:0016772,GO:0016774,GO:0019202,GO:0019752,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.3,2.7.2.4 ko:K12524,ko:K12525 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00017,M00018,M00526,M00527 R00480,R01773,R01775 RC00002,RC00043,RC00087 ko00000,ko00001,ko00002,ko01000 - - iSFV_1184.SFV_0001,iUMNK88_1353.UMNK88_4778,iYL1228.KPN_04234 AA_kinase,ACT_7,Homoserine_dh,NAD_binding_3 k59_1506304_1 1128421.JAGA01000003_gene2824 4.49e-99 303.0 COG1488@1|root,COG1488@2|Bacteria,2NNUE@2323|unclassified Bacteria 2|Bacteria H Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP pncB GO:0001666,GO:0003674,GO:0003824,GO:0004516,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009605,GO:0009607,GO:0009628,GO:0009987,GO:0016020,GO:0016740,GO:0016757,GO:0016763,GO:0016874,GO:0016879,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019365,GO:0019438,GO:0019637,GO:0019674,GO:0034355,GO:0034641,GO:0034654,GO:0036293,GO:0043094,GO:0043173,GO:0043207,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044403,GO:0044419,GO:0044464,GO:0046483,GO:0046496,GO:0047280,GO:0050896,GO:0051186,GO:0051188,GO:0051701,GO:0051704,GO:0051707,GO:0055086,GO:0070482,GO:0071704,GO:0071944,GO:0072524,GO:0072525,GO:0075136,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.4.21 ko:K00763 ko00760,ko01100,map00760,map01100 - R01724 RC00033 ko00000,ko00001,ko01000 - - iYO844.BSU31750 NAPRTase k59_92827_1 1122225.AULQ01000005_gene2449 3.07e-149 430.0 COG2010@1|root,COG2010@2|Bacteria,4NF0A@976|Bacteroidetes,1HXD9@117743|Flavobacteriia 976|Bacteroidetes C Cytochrome c actA - - - - - - - - - - - Cytochrom_C,Cytochrom_CIII,Cytochrome_C7 k59_538586_1 32057.KB217478_gene1288 2.57e-06 53.5 COG2890@1|root,COG2890@2|Bacteria,1G51W@1117|Cyanobacteria,1HMWG@1161|Nostocales 1117|Cyanobacteria J Histone methylation protein DOT1 - - - - - - - - - - - - Methyltransf_31 k59_261947_1 582744.Msip34_2499 6.07e-98 296.0 COG0232@1|root,COG0232@2|Bacteria,1MVQ2@1224|Proteobacteria,2VI7B@28216|Betaproteobacteria,2KKU8@206350|Nitrosomonadales 206350|Nitrosomonadales F Belongs to the dGTPase family. Type 2 subfamily - - 3.1.5.1 ko:K01129 ko00230,map00230 - R01856 RC00017 ko00000,ko00001,ko01000 - - - HD,HD_assoc k59_37037_1 309807.SRU_1411 6.87e-90 275.0 COG0414@1|root,COG0414@2|Bacteria,4NFT9@976|Bacteroidetes,1FIZH@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes H Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate panC GO:0003674,GO:0003824,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006573,GO:0006575,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016874,GO:0016879,GO:0016881,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901564,GO:1901566,GO:1901576,GO:1901605 6.3.2.1 ko:K01918 ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110 M00119 R02473 RC00096,RC00141 ko00000,ko00001,ko00002,ko01000 - - - Pantoate_ligase k59_1164897_1 323261.Noc_0111 7.57e-81 265.0 COG0567@1|root,COG0567@2|Bacteria,1MVBF@1224|Proteobacteria,1RN8K@1236|Gammaproteobacteria,1WWM2@135613|Chromatiales 135613|Chromatiales C Dehydrogenase E1 component sucA - 1.2.4.2 ko:K00164 ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00032 R00621,R01933,R01940,R03316,R08549 RC00004,RC00027,RC00627,RC02743,RC02833,RC02883 br01601,ko00000,ko00001,ko00002,ko01000 - - - 2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr k59_1563704_1 1122137.AQXF01000003_gene2239 3.15e-12 65.9 COG2303@1|root,COG2303@2|Bacteria,1MV19@1224|Proteobacteria,2TQKQ@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate MA20_19170 - - - - - - - - - - - GMC_oxred_C,GMC_oxred_N k59_1563704_2 397948.Cmaq_1851 0.000427 45.8 COG0589@1|root,arCOG02053@2157|Archaea,2XQTK@28889|Crenarchaeota 28889|Crenarchaeota T PFAM UspA domain protein - - - - - - - - - - - - Usp k59_1274381_1 1120956.JHZK01000057_gene1843 4.22e-34 122.0 COG2963@1|root,COG2963@2|Bacteria,1N75X@1224|Proteobacteria,2UIVT@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Transposase and inactivated derivatives - - - - - - - - - - - - HTH_28 k59_1274381_2 426117.M446_6408 2.25e-77 240.0 COG2801@1|root,COG2801@2|Bacteria,1R471@1224|Proteobacteria,2U60M@28211|Alphaproteobacteria,1JTXS@119045|Methylobacteriaceae 28211|Alphaproteobacteria L PFAM Integrase catalytic region - - - - - - - - - - - - HTH_21,rve,rve_3 k59_538595_2 323850.Shew_2689 1.17e-54 181.0 28N1N@1|root,2ZB7Q@2|Bacteria,1R86T@1224|Proteobacteria,1S7XC@1236|Gammaproteobacteria,2QBE5@267890|Shewanellaceae 1236|Gammaproteobacteria H Sulfotransferase domain - - - - - - - - - - - - Sulfotransfer_1 k59_824733_1 522306.CAP2UW1_1985 2.62e-127 381.0 COG1217@1|root,COG1217@2|Bacteria,1MV5Q@1224|Proteobacteria,2VH2W@28216|Betaproteobacteria,1KPUE@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria T GTP-binding protein typA - - ko:K06207 - - - - ko00000 - - - EFG_C,GTP_EFTU,GTP_EFTU_D2 k59_37054_1 1121923.GPUN_0698 5.87e-15 72.0 COG0858@1|root,COG0858@2|Bacteria,1MZPE@1224|Proteobacteria,1S9AF@1236|Gammaproteobacteria 1236|Gammaproteobacteria J One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA rbfA GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009266,GO:0009409,GO:0009628,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0022613,GO:0030490,GO:0033554,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0042274,GO:0043021,GO:0043024,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071840,GO:0090304,GO:1901360 - ko:K02834 - - - - ko00000,ko03009 - - - RBFA k59_714639_2 398580.Dshi_2656 4.21e-41 152.0 COG0529@1|root,COG2046@1|root,COG0529@2|Bacteria,COG2046@2|Bacteria,1MUQB@1224|Proteobacteria,2VFZH@28211|Alphaproteobacteria 28211|Alphaproteobacteria H Catalyzes the synthesis of activated sulfate cysC - 2.7.7.4 ko:K00958 ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130 M00176,M00596 R00529,R04929 RC02809,RC02889 ko00000,ko00001,ko00002,ko01000 - - - APS_kinase,ATP-sulfurylase,HTH_24,PUA_2 k59_1164919_2 580332.Slit_1737 3.7e-62 208.0 COG0441@1|root,COG0441@2|Bacteria,1MUP2@1224|Proteobacteria,2VHFD@28216|Betaproteobacteria,44V7H@713636|Nitrosomonadales 28216|Betaproteobacteria J Threonyl and Alanyl tRNA synthetase second additional domain thrS - 6.1.1.3 ko:K01868 ko00970,map00970 M00359,M00360 R03663 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,TGS,tRNA-synt_2b,tRNA_SAD k59_765909_1 360910.BAV0555 2.07e-30 114.0 COG0179@1|root,COG0179@2|Bacteria,1MUPF@1224|Proteobacteria,2VI5Z@28216|Betaproteobacteria,3T1ZZ@506|Alcaligenaceae 28216|Betaproteobacteria Q 2-keto-4-pentenoate hydratase 2-oxohepta-3-ene-17-dioic acid hydratase (catechol pathway) - - - - - - - - - - - - FAA_hydrolase k59_765909_2 404589.Anae109_2910 1.89e-48 162.0 COG2264@1|root,COG2264@2|Bacteria,1R03E@1224|Proteobacteria 1224|Proteobacteria J Ribosomal protein L11 methyltransferase (PrmA) - - - - - - - - - - - - - k59_1671358_1 1415778.JQMM01000001_gene19 2.94e-81 246.0 COG0217@1|root,COG0217@2|Bacteria,1MW3X@1224|Proteobacteria,1RP5N@1236|Gammaproteobacteria,1J4EE@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria K transcriptional regulatory protein yebC GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0009314,GO:0009628,GO:0010212,GO:0044424,GO:0044444,GO:0044464,GO:0050896 - - - - - - - - - - Transcrip_reg k59_1671358_2 247633.GP2143_10102 1.51e-06 49.3 COG0173@1|root,COG0173@2|Bacteria,1MUXB@1224|Proteobacteria,1RNMI@1236|Gammaproteobacteria,1J5H2@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn) aspS GO:0003674,GO:0003824,GO:0004812,GO:0004815,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006422,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.12 ko:K01876 ko00970,map00970 M00359,M00360 R05577 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - iSFV_1184.SFV_1868 GAD,tRNA-synt_2,tRNA_anti-codon k59_714647_1 557599.MKAN_21995 1.84e-37 144.0 COG1020@1|root,COG1020@2|Bacteria,2GISR@201174|Actinobacteria,233YJ@1762|Mycobacteriaceae 201174|Actinobacteria Q Peptide synthetase - - - ko:K16228,ko:K16229 - - - - ko00000 - - - AMP-binding,AMP-binding_C,Condensation,NAD_binding_4,PP-binding,Thioesterase k59_1790697_1 614083.AWQR01000022_gene106 1.59e-159 457.0 COG2159@1|root,COG2159@2|Bacteria,1MXI7@1224|Proteobacteria,2VP80@28216|Betaproteobacteria,4ADEX@80864|Comamonadaceae 28216|Betaproteobacteria S Amidohydrolase - - 4.1.1.103,4.1.1.46 ko:K07045,ko:K14333,ko:K20941 ko00362,ko00627,ko01120,map00362,map00627,map01120 - R00821,R11353 RC00390,RC00569 ko00000,ko00001,ko01000 - - - Amidohydro_2 k59_1790697_2 279238.Saro_0797 1.8e-225 635.0 COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2TQR1@28211|Alphaproteobacteria,2JZVD@204457|Sphingomonadales 204457|Sphingomonadales C belongs to the aldehyde dehydrogenase family - - 1.2.1.16,1.2.1.20,1.2.1.79 ko:K00135 ko00250,ko00310,ko00350,ko00650,ko00760,ko01100,ko01120,map00250,map00310,map00350,map00650,map00760,map01100,map01120 M00027 R00713,R00714,R02401 RC00080 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_775015_1 243365.CV_2301 6.19e-69 221.0 COG1932@1|root,COG1932@2|Bacteria,1MUB5@1224|Proteobacteria,2VH5M@28216|Betaproteobacteria,2KPRQ@206351|Neisseriales 206351|Neisseriales E Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine serC - 2.6.1.52 ko:K00831 ko00260,ko00680,ko00750,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map00750,map01100,map01120,map01130,map01200,map01230 M00020,M00124 R04173,R05085 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_5 k59_834021_1 1121921.KB898707_gene1148 6.11e-08 53.9 COG4775@1|root,COG4775@2|Bacteria,1MU0D@1224|Proteobacteria,1RMAP@1236|Gammaproteobacteria,2PN82@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria M Surface antigen bamA GO:0005575,GO:0005623,GO:0008104,GO:0008150,GO:0009279,GO:0009987,GO:0016020,GO:0016043,GO:0019867,GO:0022607,GO:0030312,GO:0030313,GO:0031224,GO:0031230,GO:0031241,GO:0031246,GO:0031975,GO:0032991,GO:0033036,GO:0034613,GO:0043163,GO:0043165,GO:0044085,GO:0044091,GO:0044425,GO:0044462,GO:0044464,GO:0045184,GO:0045229,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0061024,GO:0070727,GO:0071709,GO:0071840,GO:0071944,GO:0072657,GO:0090150,GO:0098552,GO:0098796,GO:1990063 - ko:K07277 - - - - ko00000,ko02000,ko03029 1.B.33 - - Bac_surface_Ag,POTRA k59_834021_2 28258.KP05_05580 2.58e-38 140.0 COG0750@1|root,COG0750@2|Bacteria,1MU91@1224|Proteobacteria,1RMIX@1236|Gammaproteobacteria,1XH5P@135619|Oceanospirillales 135619|Oceanospirillales M zinc metalloprotease rseP - - ko:K11749 ko02024,ko04112,map02024,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - PDZ,PDZ_2,Peptidase_M50 k59_1403265_1 1232683.ADIMK_3280 2.23e-72 241.0 COG0550@1|root,COG0550@2|Bacteria,1MUFZ@1224|Proteobacteria,1RNZ2@1236|Gammaproteobacteria,463YR@72275|Alteromonadaceae 1236|Gammaproteobacteria L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone topA GO:0003674,GO:0003824,GO:0003916,GO:0003917,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006265,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0016853,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051276,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360 5.99.1.2 ko:K03168 - - - - ko00000,ko01000,ko03032,ko03400 - - - Topo_Zn_Ribbon,Topoisom_bac,Toprim,Toprim_C_rpt,zf-C4_Topoisom k59_1738301_1 1131266.ARWQ01000005_gene828 1.73e-119 345.0 COG3253@1|root,arCOG03031@2157|Archaea,41SGX@651137|Thaumarchaeota 651137|Thaumarchaeota S Chlorite dismutase - - - - - - - - - - - - Chlor_dismutase k59_611321_1 1268622.AVS7_03557 2.32e-07 52.4 2A4J7@1|root,30T5U@2|Bacteria,1RGAU@1224|Proteobacteria,2VU2M@28216|Betaproteobacteria,4AE1N@80864|Comamonadaceae 28216|Betaproteobacteria S TIGRFAM MJ0042 family finger-like protein - - - - - - - - - - - - DUF3426,zinc_ribbon_4,zinc_ribbon_5 k59_611321_2 1286106.MPL1_04337 6.52e-28 111.0 COG2264@1|root,COG2264@2|Bacteria,1MUPC@1224|Proteobacteria,1RNAR@1236|Gammaproteobacteria,460E8@72273|Thiotrichales 72273|Thiotrichales J Methylates ribosomal protein L11 prmA - - ko:K02687 - - - - ko00000,ko01000,ko03009 - - - PrmA k59_894725_1 1269813.ATUL01000001_gene1018 2.46e-68 221.0 COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,1RN9T@1236|Gammaproteobacteria,1X0EW@135613|Chromatiales 135613|Chromatiales O Trypsin - - - ko:K04691 - - - - ko00000,ko01000,ko01002 - - - PDZ_2,Trypsin_2 k59_437167_1 694427.Palpr_1089 4.97e-06 54.7 COG2911@1|root,COG4675@1|root,COG5295@1|root,COG2911@2|Bacteria,COG4675@2|Bacteria,COG5295@2|Bacteria 2|Bacteria UW Hep Hag repeat protein sraP - - ko:K15125,ko:K18491,ko:K20276,ko:K21449 ko02024,ko04550,ko05133,map02024,map04550,map05133 - - - ko00000,ko00001,ko00536,ko02000,ko03000 1.B.40.2 - - Gram_pos_anchor k59_101924_1 511145.b1988 1.12e-94 283.0 COG0583@1|root,COG0583@2|Bacteria,1MXR1@1224|Proteobacteria,1RPF3@1236|Gammaproteobacteria,3XM4K@561|Escherichia 1236|Gammaproteobacteria K Transcriptional activator for the hut, put and ure operons and repressor for the gdh and gltB operons in response to nitrogen limitation. Negative regulator of its own expression (By similarity) nac GO:0003674,GO:0003700,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0140110,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:2000112,GO:2000113,GO:2001141 - ko:K19338 - - - - ko00000,ko03000 - - - HTH_1,LysR_substrate k59_834053_1 864073.HFRIS_013940 3.67e-06 47.4 COG2919@1|root,COG2919@2|Bacteria,1N7AA@1224|Proteobacteria,2VVQJ@28216|Betaproteobacteria,474N3@75682|Oxalobacteraceae 28216|Betaproteobacteria D Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic ftsB - - ko:K05589 - - - - ko00000,ko03036 - - - DivIC k59_1790744_1 1042377.AFPJ01000004_gene392 5.13e-97 303.0 COG0188@1|root,COG0188@2|Bacteria,1MURI@1224|Proteobacteria,1RMTC@1236|Gammaproteobacteria,464Q5@72275|Alteromonadaceae 1236|Gammaproteobacteria L Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule parC GO:0000819,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006265,GO:0006276,GO:0006725,GO:0006807,GO:0006996,GO:0007049,GO:0007059,GO:0007062,GO:0008150,GO:0008152,GO:0009330,GO:0009987,GO:0016020,GO:0016043,GO:0019897,GO:0019898,GO:0022402,GO:0030541,GO:0032991,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0046483,GO:0051276,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:0098813,GO:1901360,GO:1901363 - ko:K02621 - - - - ko00000,ko01000,ko02048,ko03032,ko03036 - - - DNA_gyraseA_C,DNA_topoisoIV k59_1063624_1 330214.NIDE0158 2.18e-68 223.0 COG1032@1|root,COG1032@2|Bacteria 2|Bacteria C radical SAM domain protein - - - - - - - - - - - - B12-binding,Radical_SAM k59_1063624_2 330214.NIDE0156 1.18e-07 50.1 COG2154@1|root,COG2154@2|Bacteria 2|Bacteria H pterin-4-alpha-carbinolamine dehydratase phhB GO:0003674,GO:0003824,GO:0006066,GO:0006725,GO:0006729,GO:0006732,GO:0006807,GO:0008124,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016829,GO:0016835,GO:0016836,GO:0017144,GO:0018130,GO:0019438,GO:0019751,GO:0034311,GO:0034312,GO:0034641,GO:0042558,GO:0042559,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046146,GO:0046165,GO:0046173,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 4.2.1.96 ko:K01724 ko00790,map00790 - R04734 RC01208 ko00000,ko00001,ko01000,ko04147 - - - Pterin_4a k59_1455179_1 985867.AEWF01000003_gene983 4.54e-70 236.0 COG1014@1|root,COG4231@1|root,COG1014@2|Bacteria,COG4231@2|Bacteria,1MUKS@1224|Proteobacteria,2TSHH@28211|Alphaproteobacteria,47G2C@766|Rickettsiales 766|Rickettsiales C Pyruvate ferredoxin/flavodoxin oxidoreductase - - - - - - - - - - - - POR,TPP_enzyme_C k59_103135_1 1122970.AUHC01000007_gene1711 1.68e-07 52.4 COG2064@1|root,COG2064@2|Bacteria,1MWAZ@1224|Proteobacteria,2TSFA@28211|Alphaproteobacteria,2K03P@204457|Sphingomonadales 204457|Sphingomonadales NU type II secretion system protein - - - ko:K12511 - - - - ko00000,ko02044 - - - T2SSF k59_103135_2 1096930.L284_23340 3.59e-119 348.0 COG4965@1|root,COG4965@2|Bacteria,1MUXK@1224|Proteobacteria,2TRBI@28211|Alphaproteobacteria,2K0B5@204457|Sphingomonadales 204457|Sphingomonadales U pilus assembly protein TadB - - - ko:K12510 - - - - ko00000,ko02044 - - - T2SSF k59_330549_1 1122947.FR7_0060 3.02e-05 45.8 COG0092@1|root,COG0092@2|Bacteria,1TPCP@1239|Firmicutes,4H3BP@909932|Negativicutes 909932|Negativicutes J Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation rpsC - - ko:K02982 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - KH_2,Ribosomal_S3_C k59_330549_2 926569.ANT_10110 7.74e-70 213.0 COG0197@1|root,COG0197@2|Bacteria,2G6NA@200795|Chloroflexi 200795|Chloroflexi J Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs rplP GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0097159,GO:1901363,GO:1990904 - ko:K02878 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L16 k59_1627077_1 316407.85676840 2.38e-138 403.0 COG1129@1|root,COG1129@2|Bacteria,1MU22@1224|Proteobacteria,1RMCH@1236|Gammaproteobacteria,3XQVS@561|Escherichia 1236|Gammaproteobacteria P Part of the ABC transporter complex AlsBAC involved in D-allose import. Probably responsible for energy coupling to the transport system alsA GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005354,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0005996,GO:0006810,GO:0006950,GO:0006974,GO:0008144,GO:0008150,GO:0008152,GO:0008643,GO:0008645,GO:0009987,GO:0015144,GO:0015145,GO:0015146,GO:0015148,GO:0015149,GO:0015399,GO:0015405,GO:0015407,GO:0015591,GO:0015592,GO:0015749,GO:0015750,GO:0015752,GO:0015753,GO:0015757,GO:0015765,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019321,GO:0022804,GO:0022857,GO:0030554,GO:0031224,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033554,GO:0034219,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042732,GO:0043167,GO:0043168,GO:0043190,GO:0043211,GO:0043492,GO:0044238,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051119,GO:0051179,GO:0051234,GO:0051716,GO:0055085,GO:0071702,GO:0071704,GO:0071944,GO:0097159,GO:0097367,GO:0098533,GO:0098796,GO:0098797,GO:1901264,GO:1901265,GO:1901363,GO:1901505,GO:1901656,GO:1902494,GO:1902495,GO:1904949,GO:1990351 3.6.3.17 ko:K02056,ko:K10441,ko:K10542,ko:K10545,ko:K10551 ko02010,map02010 M00212,M00214,M00215,M00217,M00221 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.2,3.A.1.2.1,3.A.1.2.13,3.A.1.2.19,3.A.1.2.3,3.A.1.2.4,3.A.1.2.6 - iEC55989_1330.EC55989_4224,iECED1_1282.ECED1_4821,iECED1_1282.ECED1_5085,iECH74115_1262.ECH74115_3282,iECNA114_1301.ECNA114_4270,iECSE_1348.ECSE_4039,iECSP_1301.ECSP_3027,iECW_1372.ECW_m4052,iEcE24377_1341.EcE24377A_4265,iSF_1195.SF3611,iS_1188.S4158,iWFL_1372.ECW_m4052 ABC_tran k59_47175_1 436308.Nmar_1394 6.11e-126 369.0 COG1867@1|root,arCOG01219@2157|Archaea,41SAG@651137|Thaumarchaeota 651137|Thaumarchaeota J Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family - - 2.1.1.215,2.1.1.216 ko:K00555 - - - - ko00000,ko01000,ko03016 - - - TRM k59_612517_1 1229909.NSED_00105 4.64e-76 238.0 COG2073@1|root,arCOG00651@2157|Archaea,41S83@651137|Thaumarchaeota 651137|Thaumarchaeota H Cobalamin synthesis G C-terminus - - 3.7.1.12 ko:K02189 ko00860,ko01100,map00860,map01100 - R07772 RC01545,RC02097 ko00000,ko00001,ko01000 - - - CbiG_C,CbiG_N,CbiG_mid k59_1063642_2 247634.GPB2148_1643 8.77e-54 173.0 COG2346@1|root,COG2346@2|Bacteria,1RH21@1224|Proteobacteria,1S98H@1236|Gammaproteobacteria,1J6JB@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Bacterial-like globin - - - ko:K06886 - - - - ko00000 - - - Bac_globin k59_1063642_3 1415778.JQMM01000001_gene1939 2.4e-23 95.5 2E5B0@1|root,33033@2|Bacteria,1ND0X@1224|Proteobacteria,1SEBX@1236|Gammaproteobacteria,1J7CC@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_1285582_1 257310.BB4456 7.31e-73 247.0 COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,1MV6G@1224|Proteobacteria,2VHYQ@28216|Betaproteobacteria,3T1U4@506|Alcaligenaceae 28216|Betaproteobacteria E Methionine synthase metH - 2.1.1.13 ko:K00548 ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230 M00017 R00946,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 - - - B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans k59_1285582_2 1396141.BATP01000029_gene2254 3.09e-44 153.0 COG1573@1|root,COG1573@2|Bacteria,46UE4@74201|Verrucomicrobia,2ITSY@203494|Verrucomicrobiae 203494|Verrucomicrobiae L uracil-dna glycosylase - - - ko:K10800 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - UDG k59_1231180_2 436308.Nmar_1725 5.2e-29 112.0 COG0301@1|root,arCOG00038@2157|Archaea,41T1A@651137|Thaumarchaeota 651137|Thaumarchaeota H Thiamine biosynthesis protein (ThiI) - - - - - - - - - - - - DUF814,ThiI k59_946618_1 1082933.MEA186_03709 4.88e-17 79.0 COG2259@1|root,COG2259@2|Bacteria,1RCKY@1224|Proteobacteria,2U6KP@28211|Alphaproteobacteria 28211|Alphaproteobacteria S DoxX - - - ko:K15977 - - - - ko00000 - - - DoxX k59_946622_1 1026882.MAMP_00031 7.75e-41 140.0 COG0217@1|root,COG0217@2|Bacteria,1MW3X@1224|Proteobacteria,1RP5N@1236|Gammaproteobacteria,45ZZ2@72273|Thiotrichales 72273|Thiotrichales K transcriptional regulatory protein - - - - - - - - - - - - Transcrip_reg k59_214819_1 319795.Dgeo_0667 1.25e-21 94.4 COG1640@1|root,COG1640@2|Bacteria,1WJDF@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus G PFAM glycoside hydrolase, family 77 malQ - 2.4.1.25 ko:K00705 ko00500,ko01100,map00500,map01100 - R05196 RC00049 ko00000,ko00001,ko01000 - GH77 - Glyco_hydro_77 k59_214819_2 1042377.AFPJ01000004_gene342 7.42e-09 59.3 COG1629@1|root,COG1629@2|Bacteria,1MWTT@1224|Proteobacteria,1RRQ9@1236|Gammaproteobacteria,464SZ@72275|Alteromonadaceae 1236|Gammaproteobacteria P COG1629 Outer membrane receptor proteins, mostly Fe transport - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - OMP_b-brl_3,Plug,TonB_dep_Rec k59_1455218_2 1144275.COCOR_03477 1.15e-08 59.3 COG2227@1|root,COG2227@2|Bacteria,1RE7I@1224|Proteobacteria,42VAD@68525|delta/epsilon subdivisions,2WRMT@28221|Deltaproteobacteria,2YVSE@29|Myxococcales 28221|Deltaproteobacteria H Methyltransferase domain - - - - - - - - - - - - Methyltransf_25,TehB k59_214831_1 1122137.AQXF01000002_gene293 2.61e-49 164.0 COG0413@1|root,COG0413@2|Bacteria,1MU3B@1224|Proteobacteria,2TQT1@28211|Alphaproteobacteria 28211|Alphaproteobacteria H Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate panB - 2.1.2.11 ko:K00606 ko00770,ko01100,ko01110,map00770,map01100,map01110 M00119 R01226 RC00022,RC00200 ko00000,ko00001,ko00002,ko01000 - - - Pantoate_transf k59_1627114_1 83406.HDN1F_10070 1.36e-75 247.0 COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,1RMZ8@1236|Gammaproteobacteria,1J59D@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria I Involved in the aerobic and anaerobic degradation of long-chain fatty acids via beta-oxidation cycle. Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA. It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate fadB GO:0003674,GO:0003824,GO:0003857,GO:0004165,GO:0004300,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0008692,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016491,GO:0016614,GO:0016616,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016854,GO:0016856,GO:0016860,GO:0016863,GO:0019395,GO:0019752,GO:0030258,GO:0032787,GO:0034440,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0046395,GO:0055114,GO:0071704,GO:0072329,GO:1901575 1.1.1.35,4.2.1.17,5.1.2.3,5.3.3.8 ko:K01782,ko:K01825 ko00071,ko00280,ko00281,ko00310,ko00362,ko00380,ko00410,ko00640,ko00650,ko00903,ko00930,ko01040,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00362,map00380,map00410,map00640,map00650,map00903,map00930,map01040,map01100,map01110,map01120,map01130,map01200,map01212 M00032,M00087 R01975,R03026,R03045,R03276,R04137,R04170,R04203,R04204,R04224,R04737,R04738,R04739,R04740,R04741,R04744,R04745,R04746,R04748,R04749,R04756,R05066,R05305,R06411,R06412,R06941,R06942,R07935,R07951,R08093,R08094 RC00029,RC00099,RC00117,RC00241,RC00525,RC00831,RC00834,RC00896,RC01078,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 - - iLF82_1304.LF82_0614,iNRG857_1313.NRG857_19200 3HCDH,3HCDH_N,ECH_1 k59_103182_1 391603.FBALC1_03447 1.97e-87 268.0 28KGY@1|root,2ZA2J@2|Bacteria,4NGFB@976|Bacteroidetes,1HYSH@117743|Flavobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_47236_1 1122137.AQXF01000002_gene173 2.34e-81 243.0 COG2867@1|root,COG2867@2|Bacteria,1RGUH@1224|Proteobacteria,2U7D8@28211|Alphaproteobacteria 28211|Alphaproteobacteria I oligoketide cyclase lipid transport protein pasT - - ko:K18588 - - - - ko00000 - - - Polyketide_cyc k59_438347_1 1122137.AQXF01000005_gene1202 1.16e-88 275.0 COG3845@1|root,COG3845@2|Bacteria,1NT0H@1224|Proteobacteria,2UPJ8@28211|Alphaproteobacteria 28211|Alphaproteobacteria S ABC transporter yufO - 3.6.3.17 ko:K02056 - M00221 - - ko00000,ko00002,ko01000,ko02000 3.A.1.2 - - ABC_tran k59_1574323_1 316407.85675446 1.37e-70 218.0 COG3170@1|root,COG3170@2|Bacteria,1RDX1@1224|Proteobacteria,1S4CU@1236|Gammaproteobacteria,3XN5I@561|Escherichia 1236|Gammaproteobacteria NU YfhG lipoprotein yfhG - - - - - - - - - - - Lipoprotein_20 k59_1574323_2 316407.1799978 2.63e-62 202.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,3XNKS@561|Escherichia 1236|Gammaproteobacteria K Member of the two-component regulatory system GlrR GlrK that up-regulates transcription of the glmY sRNA when cells enter the stationary growth phase. Regulates glmY transcription by binding to three conserved sites in the purL-glmY intergenic region yfhA GO:0000156,GO:0000160,GO:0000976,GO:0000984,GO:0001017,GO:0001067,GO:0001130,GO:0001150,GO:0001151,GO:0001158,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0023052,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0035326,GO:0035556,GO:0043170,GO:0043565,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0045893,GO:0045935,GO:0046483,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051716,GO:0060089,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2001141 - ko:K07715 ko02020,ko02024,map02020,map02024 M00502 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_1455235_1 316407.85677058 2.65e-56 178.0 COG3539@1|root,COG3539@2|Bacteria,1R7X9@1224|Proteobacteria,1RYWH@1236|Gammaproteobacteria,3XM9U@561|Escherichia 1236|Gammaproteobacteria NU pilus assembly fimI GO:0008150,GO:0009297,GO:0009987,GO:0016043,GO:0022607,GO:0030030,GO:0030031,GO:0043711,GO:0044085,GO:0071840 - ko:K07351 - - - - ko00000,ko02035 - - - Fimbrial k59_1455235_2 316407.85677057 6.6e-24 94.4 COG3539@1|root,COG3539@2|Bacteria,1QI7Y@1224|Proteobacteria,1S07V@1236|Gammaproteobacteria,3XMUH@561|Escherichia 1236|Gammaproteobacteria NU Fimbriae (also called pili), polar filaments radiating from the surface of the bacterium to a length of 0.5-1.5 micrometers and numbering 100-300 per cell, enable bacteria to colonize the epithelium of specific host organs fimA GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0007155,GO:0008150,GO:0009289,GO:0022610,GO:0042802,GO:0042995,GO:0044464 - ko:K07345 ko05133,map05133 - - - ko00000,ko00001,ko02035,ko02044 - - - Fimbrial k59_1341849_1 247634.GPB2148_1001 9.69e-11 60.5 COG0632@1|root,COG0632@2|Bacteria,1MWJR@1224|Proteobacteria,1RMET@1236|Gammaproteobacteria,1J5QQ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB ruvA GO:0000217,GO:0000400,GO:0000725,GO:0003674,GO:0003676,GO:0003677,GO:0003678,GO:0003824,GO:0004386,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0007154,GO:0008150,GO:0008152,GO:0009314,GO:0009378,GO:0009379,GO:0009432,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0022607,GO:0031668,GO:0032392,GO:0032508,GO:0032991,GO:0033202,GO:0033554,GO:0034641,GO:0042802,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0051259,GO:0051260,GO:0051262,GO:0051276,GO:0051289,GO:0051716,GO:0065003,GO:0071103,GO:0071496,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1902494 3.6.4.12 ko:K03550 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - HHH_5,RuvA_C,RuvA_N k59_1341849_2 1121937.AUHJ01000007_gene1904 5.46e-163 462.0 COG2255@1|root,COG2255@2|Bacteria,1MU38@1224|Proteobacteria,1RNWY@1236|Gammaproteobacteria,464S4@72275|Alteromonadaceae 1236|Gammaproteobacteria L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing ruvB GO:0000725,GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0007154,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009314,GO:0009378,GO:0009411,GO:0009416,GO:0009432,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0031668,GO:0032392,GO:0032508,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0051276,GO:0051716,GO:0070035,GO:0071103,GO:0071496,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360 3.6.4.12 ko:K03551 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - RuvB_C,RuvB_N k59_438358_1 596319.STAWA0001_1849 7.27e-05 52.8 COG5002@1|root,COG5002@2|Bacteria,1TQ1H@1239|Firmicutes,4HBZ0@91061|Bacilli,4GX1A@90964|Staphylococcaceae 91061|Bacilli T Histidine kinase resE - 2.7.13.3 ko:K07651 ko02020,map02020 M00458 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HAMP,HATPase_c,HisKA,PAS,PAS_4 k59_1175228_1 394221.Mmar10_1053 1.62e-138 420.0 COG1629@1|root,COG4771@2|Bacteria,1MW7D@1224|Proteobacteria,2TS7D@28211|Alphaproteobacteria,440TT@69657|Hyphomonadaceae 28211|Alphaproteobacteria P COG1629 Outer membrane receptor proteins, mostly Fe transport - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_1455250_1 748658.KB907321_gene851 3.35e-25 97.4 COG1694@1|root,COG1694@2|Bacteria,1N02D@1224|Proteobacteria,1SC23@1236|Gammaproteobacteria,1WYS1@135613|Chromatiales 135613|Chromatiales S MazG-like family - - - - - - - - - - - - MazG-like k59_1455250_2 1357275.AVEL02000123_gene3650 2.24e-30 120.0 COG1297@1|root,COG1297@2|Bacteria,1N7SK@1224|Proteobacteria,1RNC8@1236|Gammaproteobacteria,1Z9GJ@136849|Pseudomonas syringae group 1236|Gammaproteobacteria S Oligopeptide transporter, OPT family oliA GO:0003674,GO:0005215,GO:0005575,GO:0006810,GO:0008150,GO:0016020,GO:0022857,GO:0051179,GO:0051234,GO:0055085 - - - - - - - - - - OPT k59_157657_1 5970.XP_009158178.1 1.62e-14 81.3 COG0553@1|root,KOG1001@2759|Eukaryota,38E02@33154|Opisthokonta,3NTZ9@4751|Fungi,3QKX1@4890|Ascomycota,20EYG@147545|Eurotiomycetes,3MSDU@451870|Chaetothyriomycetidae 4751|Fungi A SNF2 family N-terminal domain - GO:0000003,GO:0000109,GO:0000113,GO:0000228,GO:0000775,GO:0000776,GO:0000777,GO:0000778,GO:0000779,GO:0000780,GO:0000793,GO:0000794,GO:0003006,GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005694,GO:0005730,GO:0005737,GO:0005739,GO:0006139,GO:0006259,GO:0006281,GO:0006282,GO:0006289,GO:0006325,GO:0006333,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0007530,GO:0007531,GO:0007533,GO:0008094,GO:0008150,GO:0008152,GO:0009892,GO:0009987,GO:0010605,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019219,GO:0019222,GO:0022413,GO:0022414,GO:0030154,GO:0031323,GO:0031324,GO:0031974,GO:0031981,GO:0032182,GO:0032183,GO:0032502,GO:0032505,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0044237,GO:0044238,GO:0044260,GO:0044422,GO:0044424,GO:0044427,GO:0044428,GO:0044444,GO:0044446,GO:0044454,GO:0044464,GO:0045165,GO:0045738,GO:0045934,GO:0046483,GO:0048519,GO:0048523,GO:0048583,GO:0048585,GO:0048869,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051053,GO:0051171,GO:0051172,GO:0051276,GO:0051716,GO:0060255,GO:0065007,GO:0070013,GO:0071704,GO:0071840,GO:0080090,GO:0080134,GO:0080135,GO:0090304,GO:0097159,GO:0098687,GO:1901360,GO:1901363,GO:1990391,GO:2000779,GO:2000780,GO:2001020,GO:2001021,GO:2001032,GO:2001033 - - - - - - - - - - Helicase_C,SNF2_N k59_330598_1 1122137.AQXF01000007_gene3566 5.81e-60 206.0 COG1640@1|root,COG1640@2|Bacteria,1QTVJ@1224|Proteobacteria,2TW4K@28211|Alphaproteobacteria 28211|Alphaproteobacteria G 4-alpha-glucanotransferase malQ - 2.4.1.25,5.4.99.15 ko:K00705,ko:K06044 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R01824,R05196,R09995 RC00049 ko00000,ko00001,ko00002,ko01000 - GH13,GH77 - Alpha-amylase,Glyco_hydro_77 k59_612591_1 1123279.ATUS01000006_gene3486 4.65e-85 265.0 COG0160@1|root,COG0160@2|Bacteria,1MWY6@1224|Proteobacteria,1RQKU@1236|Gammaproteobacteria,1J55Z@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Aminotransferase class-III - - 2.6.1.76 ko:K00836 ko00260,ko01100,ko01120,ko01210,ko01230,map00260,map01100,map01120,map01210,map01230 M00033 R06977 RC00006,RC00062 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 k59_664804_1 1229909.NSED_08530 6.38e-88 265.0 COG4742@1|root,arCOG04362@2157|Archaea,41SGE@651137|Thaumarchaeota 651137|Thaumarchaeota K Transcriptional regulator - - - - - - - - - - - - HTH_20,HTH_5 k59_438381_1 714961.BFZC1_01907 9.71e-31 124.0 COG0442@1|root,COG0442@2|Bacteria,1TRBV@1239|Firmicutes,4H9NN@91061|Bacilli,3IWX8@400634|Lysinibacillus 91061|Bacilli J Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS proS - 6.1.1.15 ko:K01881 ko00970,map00970 M00359,M00360 R03661 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,tRNA-synt_2b,tRNA_edit k59_1341858_1 1317118.ATO8_08351 2.38e-24 108.0 COG2931@1|root,COG3506@1|root,COG3507@1|root,COG2931@2|Bacteria,COG3506@2|Bacteria,COG3507@2|Bacteria 2|Bacteria G Belongs to the glycosyl hydrolase 43 family - - - ko:K09702 - - - - ko00000 - - - CBM_6,Calx-beta,DUF1349,GSDH,Laminin_G_3,PKD,ThuA k59_157662_1 1294273.roselon_01984 7.7e-104 320.0 COG0529@1|root,COG2046@1|root,COG0529@2|Bacteria,COG2046@2|Bacteria,1MUQB@1224|Proteobacteria,2VFZH@28211|Alphaproteobacteria 28211|Alphaproteobacteria H Catalyzes the synthesis of activated sulfate cysC - 2.7.7.4 ko:K00958 ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130 M00176,M00596 R00529,R04929 RC02809,RC02889 ko00000,ko00001,ko00002,ko01000 - - - APS_kinase,ATP-sulfurylase,HTH_24,PUA_2 k59_1231234_2 1026882.MAMP_02063 5e-10 59.7 COG1226@1|root,COG1226@2|Bacteria,1QYC1@1224|Proteobacteria 1224|Proteobacteria P COG1226 Kef-type K transport systems - - - ko:K10716 - - - - ko00000,ko02000 1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6 - - Ion_trans,Ion_trans_2 k59_895907_1 1123253.AUBD01000004_gene1108 1.1e-102 309.0 COG0240@1|root,COG0240@2|Bacteria,1MUU3@1224|Proteobacteria,1RPQ7@1236|Gammaproteobacteria,1X2XQ@135614|Xanthomonadales 135614|Xanthomonadales I Glycerol-3-phosphate dehydrogenase gpsA - 1.1.1.94 ko:K00057 ko00564,ko01110,map00564,map01110 - R00842,R00844 RC00029 ko00000,ko00001,ko01000 - - - NAD_Gly3P_dh_C,NAD_Gly3P_dh_N k59_494011_2 436308.Nmar_1104 1.86e-160 476.0 COG0178@1|root,arCOG04694@2157|Archaea,41T01@651137|Thaumarchaeota 651137|Thaumarchaeota L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate uvrA - - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - ABC_tran k59_1791831_1 436308.Nmar_0213 2.64e-49 158.0 arCOG10521@1|root,arCOG10521@2157|Archaea,41T8A@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1574353_1 566466.NOR53_2204 3.99e-64 206.0 COG0608@1|root,COG0608@2|Bacteria,1N37P@1224|Proteobacteria,1RQTR@1236|Gammaproteobacteria,1J9D8@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L single-stranded DNA 5'-3' exodeoxyribonuclease activity - - - - - - - - - - - - DHHA1 k59_1116524_1 1415778.JQMM01000001_gene27 1.34e-64 216.0 COG0342@1|root,COG0342@2|Bacteria,1MV5U@1224|Proteobacteria,1RMIQ@1236|Gammaproteobacteria,1J4DW@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA secD GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944 - ko:K03072 ko03060,ko03070,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 2.A.6.4,3.A.5.2,3.A.5.7 - - SecD-TM1,SecD_SecF,Sec_GG k59_1404492_1 859657.RPSI07_2149 9.73e-56 195.0 COG0557@1|root,COG0557@2|Bacteria,1MUS6@1224|Proteobacteria,2VHBJ@28216|Betaproteobacteria,1K3JV@119060|Burkholderiaceae 28216|Betaproteobacteria J 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs rnr - - ko:K12573 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03016,ko03019 - - - OB_RNB,RNB,S1 k59_1516948_1 13690.CP98_04752 1.16e-41 153.0 COG0642@1|root,COG2205@2|Bacteria,1MUAK@1224|Proteobacteria,2U2UG@28211|Alphaproteobacteria,2K457@204457|Sphingomonadales 204457|Sphingomonadales T HAMP domain - - - - - - - - - - - - HATPase_c k59_946718_1 1283300.ATXB01000002_gene3113 2.54e-12 72.0 COG3391@1|root,COG3794@1|root,COG3391@2|Bacteria,COG3794@2|Bacteria,1NU68@1224|Proteobacteria,1SM3H@1236|Gammaproteobacteria,1XG3J@135618|Methylococcales 135618|Methylococcales C amine dehydrogenase activity - - - - - - - - - - - - - k59_664820_1 396588.Tgr7_1276 5.35e-93 297.0 COG0068@1|root,COG0068@2|Bacteria,1MVP8@1224|Proteobacteria,1RP08@1236|Gammaproteobacteria,1WX2T@135613|Chromatiales 135613|Chromatiales O Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide - - - ko:K04656 - - - - ko00000 - - - Acylphosphatase,Sua5_yciO_yrdC,zf-HYPF k59_1404494_2 631362.Thi970DRAFT_02906 1.43e-09 57.8 COG3267@1|root,COG3267@2|Bacteria,1REWJ@1224|Proteobacteria,1S518@1236|Gammaproteobacteria,1X0QD@135613|Chromatiales 135613|Chromatiales U Type II secretory pathway, component ExeA - - - - - - - - - - - - AAA_22 k59_1791866_1 436308.Nmar_0976 5.98e-74 231.0 COG0614@1|root,arCOG04233@2157|Archaea,41SXD@651137|Thaumarchaeota 651137|Thaumarchaeota P Periplasmic binding protein - - - ko:K02016 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko02000 3.A.1.14 - - Peripla_BP_2 k59_272936_1 948565.AFFP02000004_gene723 0.000522 42.7 COG0443@1|root,COG0443@2|Bacteria,1MVQI@1224|Proteobacteria,1RN74@1236|Gammaproteobacteria,1Y6W1@135625|Pasteurellales 135625|Pasteurellales O Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB hscA - - ko:K04044 - - - - ko00000,ko03110 1.A.33 - - HSP70 k59_272936_2 1207076.ALAT01000147_gene275 1.59e-55 175.0 COG0633@1|root,COG0633@2|Bacteria,1RHDC@1224|Proteobacteria,1S5XW@1236|Gammaproteobacteria,1Z31B@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria C Ferredoxin fdx - - ko:K04755 - - - - ko00000 - - - Fer2 k59_1116559_1 1115803.HMPREF1129_2526 6.68e-26 103.0 COG0518@1|root,COG0518@2|Bacteria,2GKS1@201174|Actinobacteria,4D4Y3@85005|Actinomycetales 201174|Actinobacteria F Glutamine amidotransferase class-I - - 6.3.5.2 ko:K01951 ko00230,ko00983,ko01100,map00230,map00983,map01100 M00050 R01230,R01231,R08244 RC00010,RC00204 ko00000,ko00001,ko00002,ko01000,ko01002 - - - GATase k59_1116559_2 1121937.AUHJ01000008_gene2013 5.1e-14 71.2 2BWJV@1|root,32U7J@2|Bacteria,1N47S@1224|Proteobacteria,1SAYP@1236|Gammaproteobacteria,468PF@72275|Alteromonadaceae 1236|Gammaproteobacteria - - - - - - - - - - - - - - Frag1 k59_1691808_2 857087.Metme_3857 0.000417 42.0 COG2206@1|root,COG2206@2|Bacteria,1MW7F@1224|Proteobacteria,1RPEZ@1236|Gammaproteobacteria 1236|Gammaproteobacteria T COG2206 HD-GYP domain - - - - - - - - - - - - DUF3391,HD,HD_5 k59_1073037_1 1122137.AQXF01000005_gene1331 7.47e-80 270.0 COG4625@1|root,COG4625@2|Bacteria,1N0PT@1224|Proteobacteria,2TTFH@28211|Alphaproteobacteria 28211|Alphaproteobacteria EQ Autotransporter beta- domain protein - - - - - - - - - - - - Autotransporter k59_282371_1 436308.Nmar_0582 1.01e-104 311.0 COG0150@1|root,arCOG00639@2157|Archaea,41SEE@651137|Thaumarchaeota 651137|Thaumarchaeota F Phosphoribosylformylglycinamidine cyclo-ligase purM - 6.3.3.1 ko:K01933 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04208 RC01100 ko00000,ko00001,ko00002,ko01000 - - - AIRS,AIRS_C k59_558979_1 1499967.BAYZ01000155_gene654 2.71e-64 215.0 COG0445@1|root,COG0445@2|Bacteria,2NNXQ@2323|unclassified Bacteria 2|Bacteria D NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 gidA GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009314,GO:0009411,GO:0009416,GO:0009451,GO:0009628,GO:0009987,GO:0010467,GO:0016070,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0050896,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901363 - ko:K03495 - - R08701 RC00053,RC00209,RC00870 ko00000,ko03016,ko03036 - - - GIDA,GIDA_assoc k59_1073040_3 765914.ThisiDRAFT_0560 1.49e-77 271.0 COG0642@1|root,COG5002@1|root,COG0642@2|Bacteria,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,1T1JE@1236|Gammaproteobacteria,1WWPB@135613|Chromatiales 135613|Chromatiales T Signal transduction histidine kinase, subgroup 1, dimerisation phosphoacceptor - - - - - - - - - - - - HATPase_c,HisKA,Hpt,PAS,PAS_3,PAS_4,PAS_9,Response_reg,dCache_3 k59_1464862_1 269799.Gmet_2466 3.51e-53 184.0 COG3267@1|root,COG3271@1|root,COG3409@1|root,COG3267@2|Bacteria,COG3271@2|Bacteria,COG3409@2|Bacteria,1MU3G@1224|Proteobacteria,42N7S@68525|delta/epsilon subdivisions,2WMBC@28221|Deltaproteobacteria,43SAE@69541|Desulfuromonadales 28221|Deltaproteobacteria MU SMART AAA ATPase exeA - - ko:K02450 - M00331 - - ko00000,ko00002,ko02044 9.B.42 - - AAA_22,PG_binding_1 k59_673998_1 1144305.PMI02_03854 3.28e-111 327.0 COG0382@1|root,COG0382@2|Bacteria,1MV4Q@1224|Proteobacteria,2TT3I@28211|Alphaproteobacteria,2K0XU@204457|Sphingomonadales 204457|Sphingomonadales H Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate ubiA - 2.5.1.39 ko:K03179 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00117 R05000,R05615 RC00209,RC02895 ko00000,ko00001,ko00002,ko01000,ko01006 - - - UbiA k59_1184494_1 1122137.AQXF01000003_gene2250 7.6e-83 273.0 COG4219@1|root,COG4219@2|Bacteria 2|Bacteria - - - - - ko:K03641 - - - - ko00000,ko02000 2.C.1.2 - - LysM,PD40 k59_447859_1 483219.LILAB_29335 1.21e-84 267.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,2YTW0@29|Myxococcales 28221|Deltaproteobacteria T response regulator - - - ko:K02481,ko:K07713 ko02020,map02020 M00499 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_1351122_1 436308.Nmar_1267 2.58e-103 323.0 COG0294@1|root,COG1410@1|root,arCOG02029@2157|Archaea,arCOG02817@2157|Archaea,41SXT@651137|Thaumarchaeota 651137|Thaumarchaeota E Methionine synthase - - 2.1.1.13 ko:K00548 ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230 M00017 R00946,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 - - - B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind k59_167155_1 443152.MDG893_09331 1.18e-77 237.0 COG0177@1|root,COG0177@2|Bacteria,1MUYQ@1224|Proteobacteria,1RMHU@1236|Gammaproteobacteria,465DF@72275|Alteromonadaceae 1236|Gammaproteobacteria L DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate nth GO:0000702,GO:0000703,GO:0003674,GO:0003824,GO:0003906,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006285,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009314,GO:0009411,GO:0009416,GO:0009628,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034641,GO:0034644,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0048037,GO:0050896,GO:0051536,GO:0051539,GO:0051540,GO:0051716,GO:0071214,GO:0071478,GO:0071482,GO:0071704,GO:0090304,GO:0104004,GO:0140097,GO:1901360 4.2.99.18 ko:K10773 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - EndIII_4Fe-2S,HhH-GPD k59_1073052_1 1320556.AVBP01000010_gene3085 1.33e-19 88.2 COG2197@1|root,COG2197@2|Bacteria,1R2YT@1224|Proteobacteria,2TZTV@28211|Alphaproteobacteria 28211|Alphaproteobacteria KT Autoinducer binding domain - - - - - - - - - - - - Autoind_bind,GerE k59_674014_1 641526.ADIWIN_4031 5.45e-100 299.0 COG1012@1|root,COG1012@2|Bacteria,4NEEZ@976|Bacteroidetes,1HWNH@117743|Flavobacteriia 976|Bacteroidetes C acyl-CoA reductase - - - - - - - - - - - - LuxC k59_559000_1 483219.LILAB_20235 1.5e-64 216.0 COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,42M51@68525|delta/epsilon subdivisions,2WIPP@28221|Deltaproteobacteria,2YUKY@29|Myxococcales 28221|Deltaproteobacteria NU Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB gspE - - ko:K02454 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - T2SSE,T2SSE_N k59_1295250_1 1120797.KB908258_gene1387 2.62e-54 178.0 2B8WY@1|root,32278@2|Bacteria,2H6HR@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - - k59_282405_1 519989.ECTPHS_03854 1.63e-23 107.0 COG0643@1|root,COG2198@1|root,COG0643@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,1RMS6@1236|Gammaproteobacteria,1WWZQ@135613|Chromatiales 135613|Chromatiales T response regulator receiver - - - ko:K02487,ko:K06596 ko02020,ko02025,map02020,map02025 M00507 - - ko00000,ko00001,ko00002,ko01001,ko02022,ko02035 - - - CheW,H-kinase_dim,HATPase_c,Hpt,Response_reg k59_112830_1 1123054.KB907702_gene1647 6.89e-40 147.0 COG1680@1|root,COG1680@2|Bacteria,1MY01@1224|Proteobacteria,1RNUI@1236|Gammaproteobacteria,1X1ED@135613|Chromatiales 135613|Chromatiales V Beta-lactamase - - - - - - - - - - - - Beta-lactamase k59_112830_2 351348.Maqu_0507 3.51e-42 148.0 COG0596@1|root,COG0596@2|Bacteria,1R9X7@1224|Proteobacteria,1S2CW@1236|Gammaproteobacteria,466G8@72275|Alteromonadaceae 1236|Gammaproteobacteria S hydrolases or acyltransferases (alpha beta hydrolase superfamily) ybfF GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016787,GO:0016788,GO:0016790,GO:0044424,GO:0044444,GO:0044464,GO:0052689 - ko:K01175 - - - - ko00000,ko01000 - - - Abhydrolase_1,Abhydrolase_6 k59_1351147_1 436308.Nmar_0432 7.71e-114 330.0 COG0689@1|root,arCOG01575@2157|Archaea,41S81@651137|Thaumarchaeota 651137|Thaumarchaeota J Catalytic component of the exosome, which is a complex involved in RNA degradation. Has 3'- 5' exoribonuclease activity. Can also synthesize heteropolymeric RNA-tails rrp41 - - ko:K11600 ko03018,map03018 M00390,M00391 - - ko00000,ko00001,ko00002,ko03019 - - - RNase_PH,RNase_PH_C k59_167188_1 1265313.HRUBRA_01686 2.04e-30 117.0 COG0688@1|root,COG0688@2|Bacteria,1MVT4@1224|Proteobacteria,1RN1U@1236|Gammaproteobacteria 1236|Gammaproteobacteria I Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer) psd - 4.1.1.65 ko:K01613 ko00564,ko01100,ko01110,map00564,map01100,map01110 M00093 R02055 RC00299 ko00000,ko00001,ko00002,ko01000 - - - PS_Dcarbxylase k59_167188_2 318586.Pden_1654 9.67e-14 73.2 COG2269@1|root,COG2269@2|Bacteria,1MU97@1224|Proteobacteria,2TRD4@28211|Alphaproteobacteria,2PVM3@265|Paracoccus 28211|Alphaproteobacteria J tRNA synthetases class II (D, K and N) genX - - ko:K04568 - - - - ko00000,ko01000,ko03012 - - - tRNA-synt_2 k59_1011588_1 458817.Shal_2955 1.51e-76 234.0 COG1788@1|root,COG1788@2|Bacteria,1MVEI@1224|Proteobacteria,1RNXB@1236|Gammaproteobacteria,2QB50@267890|Shewanellaceae 1236|Gammaproteobacteria I Coenzyme A transferase pcaI - 2.8.3.5,2.8.3.6 ko:K01027,ko:K01028,ko:K01031 ko00072,ko00280,ko00362,ko00650,ko01100,ko01120,map00072,map00280,map00362,map00650,map01100,map01120 - R00410,R02990 RC00014 ko00000,ko00001,ko01000 - - - CoA_trans k59_845328_1 246200.SPO1889 2.84e-12 71.6 COG1064@1|root,COG1064@2|Bacteria,1MUTT@1224|Proteobacteria,2TS0W@28211|Alphaproteobacteria,4NAHS@97050|Ruegeria 28211|Alphaproteobacteria C Alcohol dehydrogenase GroES-like domain - - 1.1.1.1 ko:K00001 ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220 - R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310 RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273 ko00000,ko00001,ko01000 - - - ADH_N,ADH_zinc_N k59_845328_2 1283283.ATXA01000001_gene895 1.32e-39 143.0 COG0372@1|root,COG0372@2|Bacteria,2GJ7E@201174|Actinobacteria,4ESB0@85013|Frankiales 201174|Actinobacteria C Belongs to the citrate synthase family gltA GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0044424,GO:0044444,GO:0044464,GO:0071944 2.3.3.1 ko:K01647 ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00740 R00351 RC00004,RC00067 br01601,ko00000,ko00001,ko00002,ko01000 - - - Citrate_synt k59_167206_1 653045.Strvi_1277 6.21e-14 79.7 COG0515@1|root,COG0515@2|Bacteria,2IBAC@201174|Actinobacteria 201174|Actinobacteria KLT Protein tyrosine kinase - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase k59_1011594_1 1123504.JQKD01000035_gene2668 7.88e-19 91.3 COG0768@1|root,COG0768@2|Bacteria,1MV8C@1224|Proteobacteria,2VHBZ@28216|Betaproteobacteria,4AAEW@80864|Comamonadaceae 28216|Betaproteobacteria M Catalyzes cross-linking of the peptidoglycan cell wall mrdA - 3.4.16.4 ko:K05515 ko00550,ko01501,map00550,map01501 - - - ko00000,ko00001,ko01000,ko01011 - - - PBP_dimer,Transpeptidase k59_1801216_1 1123073.KB899241_gene3395 5.64e-92 284.0 COG0624@1|root,COG0624@2|Bacteria,1R96A@1224|Proteobacteria,1RSD6@1236|Gammaproteobacteria,1X5K9@135614|Xanthomonadales 135614|Xanthomonadales E Peptidase dimerisation domain - - - - - - - - - - - - M20_dimer,Peptidase_M20 k59_503102_1 1454004.AW11_03381 3.55e-44 161.0 COG3386@1|root,COG3386@2|Bacteria,1QW76@1224|Proteobacteria 1224|Proteobacteria G PFAM SMP-30 Gluconolaconase - - - - - - - - - - - - - k59_1073111_1 234267.Acid_2554 2.12e-71 230.0 COG3344@1|root,COG3344@2|Bacteria 2|Bacteria L reverse transcriptase - - 2.7.7.49 ko:K00986 - - - - ko00000,ko01000 - - - GIIM,RVT_1 k59_1126107_1 941449.dsx2_1668 6.08e-51 180.0 COG1157@1|root,COG1157@2|Bacteria,1MUH6@1224|Proteobacteria,42M0K@68525|delta/epsilon subdivisions,2WISR@28221|Deltaproteobacteria,2M909@213115|Desulfovibrionales 28221|Deltaproteobacteria NU PFAM H transporting two-sector ATPase alpha beta subunit central region fliI - 3.6.3.14 ko:K02412 ko02040,map02040 - - - ko00000,ko00001,ko01000,ko02035,ko02044 3.A.6.2,3.A.6.3 - - ATP-synt_ab,ATP-synt_ab_N k59_956171_1 247633.GP2143_04550 1.42e-21 98.6 COG3917@1|root,COG3917@2|Bacteria,1MV6E@1224|Proteobacteria,1RYQD@1236|Gammaproteobacteria 1236|Gammaproteobacteria Q 2-hydroxychromene-2-carboxylate isomerase - - - - - - - - - - - - DSBA k59_1126122_1 1122137.AQXF01000002_gene103 6.51e-75 241.0 COG0544@1|root,COG0544@2|Bacteria,1MUJP@1224|Proteobacteria,2TS8W@28211|Alphaproteobacteria 28211|Alphaproteobacteria D Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase tig GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 - ko:K03545 - - - - ko00000 - - - FKBP_C,Trigger_C,Trigger_N k59_282469_1 1122137.AQXF01000001_gene3174 6.56e-92 284.0 COG1508@1|root,COG1508@2|Bacteria,1MW4V@1224|Proteobacteria,2TS41@28211|Alphaproteobacteria 28211|Alphaproteobacteria K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released rpoN - - ko:K03092 ko02020,ko05111,map02020,map05111 - - - ko00000,ko00001,ko03021 - - - Sigma54_AID,Sigma54_CBD,Sigma54_DBD k59_1351208_1 1229909.NSED_09310 1.05e-104 305.0 arCOG08765@1|root,arCOG08765@2157|Archaea,41SQJ@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_167242_1 1245471.PCA10_24740 1.94e-85 270.0 COG1030@1|root,COG1030@2|Bacteria,1MUJN@1224|Proteobacteria,1RN3U@1236|Gammaproteobacteria,1YF0S@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria O NfeD-like C-terminal, partner-binding nfeD - - ko:K07403 - - - - ko00000 - - - NfeD k59_1240575_1 1869.MB27_17200 2.92e-20 97.4 COG1960@1|root,COG1960@2|Bacteria,2GKVN@201174|Actinobacteria,4DD87@85008|Micromonosporales 201174|Actinobacteria I Acyl-CoA dehydrogenase, C-terminal domain fadE33 - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_N k59_1240575_2 67267.JNXT01000033_gene1754 6.06e-05 47.4 COG1960@1|root,COG1960@2|Bacteria,2GM1Q@201174|Actinobacteria 201174|Actinobacteria I acyl-CoA dehydrogenase - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_1748846_2 1411685.U062_02136 7.3e-37 143.0 COG1629@1|root,COG4771@2|Bacteria,1MWKN@1224|Proteobacteria,1RNZX@1236|Gammaproteobacteria 1236|Gammaproteobacteria P receptor viuA - - - - - - - - - - - Plug,TonB_dep_Rec k59_1011638_1 323848.Nmul_A1426 4.22e-64 218.0 COG4772@1|root,COG4772@2|Bacteria,1MUIH@1224|Proteobacteria,2VKC9@28216|Betaproteobacteria,372G4@32003|Nitrosomonadales 28216|Betaproteobacteria P TonB-dependent Receptor Plug Domain yncD - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_1691973_3 1121374.KB891576_gene511 1.86e-12 66.2 28NHW@1|root,2ZBJG@2|Bacteria,1RBJB@1224|Proteobacteria,1S31B@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_112924_1 886293.Sinac_1812 1.82e-45 154.0 COG4430@1|root,COG4430@2|Bacteria,2J0DY@203682|Planctomycetes 203682|Planctomycetes S Bacteriocin-protection, YdeI or OmpD-Associated - - - - - - - - - - - - OmdA k59_1748850_1 1168065.DOK_19020 1.74e-09 57.8 COG0830@1|root,COG0830@2|Bacteria,1MW8Q@1224|Proteobacteria,1RP91@1236|Gammaproteobacteria,1J6BW@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O Required for maturation of urease via the functional incorporation of the urease nickel metallocenter ureF - - ko:K03188 - - - - ko00000 - - - UreF k59_1748850_2 187272.Mlg_0185 2.08e-49 162.0 COG2371@1|root,COG2371@2|Bacteria,1MZQZ@1224|Proteobacteria,1S6R9@1236|Gammaproteobacteria,1WYV9@135613|Chromatiales 135613|Chromatiales O Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly ureE - - ko:K03187 - - - - ko00000 - - - UreE_C,UreE_N k59_167254_1 436229.JOEH01000032_gene3693 5.77e-18 97.1 COG1674@1|root,COG1674@2|Bacteria,2GJD6@201174|Actinobacteria,2NF2I@228398|Streptacidiphilus 201174|Actinobacteria D PFAM cell divisionFtsK SpoIIIE - - - ko:K03466 - - - - ko00000,ko03036 3.A.12 - - DUF3631,FtsK_SpoIIIE k59_1636635_1 1123366.TH3_21820 3.05e-103 304.0 COG3293@1|root,COG3293@2|Bacteria,1PVIT@1224|Proteobacteria,2TURP@28211|Alphaproteobacteria,2JW1A@204441|Rhodospirillales 204441|Rhodospirillales L Putative transposase of IS4/5 family (DUF4096) - - - - - - - - - - - - DDE_Tnp_1,DUF4096 k59_1126157_1 1122137.AQXF01000003_gene2414 2.24e-182 514.0 COG1290@1|root,COG1290@2|Bacteria,1MV97@1224|Proteobacteria,2TSZ3@28211|Alphaproteobacteria 28211|Alphaproteobacteria C Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis petB - - ko:K00410,ko:K00412 ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016 M00151,M00152 - - ko00000,ko00001,ko00002,ko03029 - - - Cytochrom_B_C,Cytochrom_C1,Cytochrome_B k59_1011659_2 1229909.NSED_01885 5.1e-76 228.0 COG1717@1|root,arCOG00781@2157|Archaea,41SP5@651137|Thaumarchaeota 651137|Thaumarchaeota J ribosomal protein - - - ko:K02912 ko03010,map03010 M00177,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L32e k59_224401_1 883126.HMPREF9710_01035 8.44e-16 83.2 COG4773@1|root,COG4773@2|Bacteria,1QTXJ@1224|Proteobacteria,2VPMU@28216|Betaproteobacteria,47698@75682|Oxalobacteraceae 28216|Betaproteobacteria P TonB dependent receptor - - - - - - - - - - - - Plug,TonB_dep_Rec k59_1184605_1 1122137.AQXF01000002_gene115 7.23e-257 721.0 COG1034@1|root,COG1034@2|Bacteria,1P8MN@1224|Proteobacteria,2TS97@28211|Alphaproteobacteria 28211|Alphaproteobacteria C NADH-quinone oxidoreductase nuoG - 1.6.5.3 ko:K00336 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Fer2_4,Molybdopterin,NADH-G_4Fe-4S_3,NADH_dhqG_C k59_785662_1 1380394.JADL01000004_gene6018 3.76e-69 222.0 COG1104@1|root,COG1104@2|Bacteria,1MU1C@1224|Proteobacteria,2TSQE@28211|Alphaproteobacteria,2JPHR@204441|Rhodospirillales 204441|Rhodospirillales E Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins iscS - 2.8.1.7 ko:K04487 ko00730,ko01100,ko04122,map00730,map01100,map04122 - R07460,R11528,R11529 RC01789,RC02313 ko00000,ko00001,ko01000,ko02048,ko03016,ko03029 - - - Aminotran_5 k59_674114_1 68170.KL590544_gene820 5.37e-37 140.0 COG2366@1|root,COG2366@2|Bacteria,2GISQ@201174|Actinobacteria,4DXZP@85010|Pseudonocardiales 201174|Actinobacteria S Penicillin amidase - - 3.5.1.11 ko:K01434 ko00311,ko01130,map00311,map01130 - R02170 RC00166,RC00328 ko00000,ko00001,ko01000,ko01002 - - - Penicil_amidase k59_674114_2 367299.JOEE01000001_gene1664 8.41e-34 125.0 291ZT@1|root,2ZPJ4@2|Bacteria,2GR7R@201174|Actinobacteria,4FGNC@85021|Intrasporangiaceae 201174|Actinobacteria S Protein of unknown function (DUF2587) bpa GO:0000502,GO:0003674,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0008150,GO:0009893,GO:0009894,GO:0009896,GO:0009987,GO:0010604,GO:0016020,GO:0016043,GO:0019222,GO:0022607,GO:0022624,GO:0030162,GO:0030312,GO:0031323,GO:0031325,GO:0031329,GO:0031331,GO:0032268,GO:0032270,GO:0032991,GO:0042176,GO:0043933,GO:0044085,GO:0044424,GO:0044464,GO:0044877,GO:0045732,GO:0045862,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0051259,GO:0051260,GO:0060255,GO:0061136,GO:0065003,GO:0065007,GO:0070628,GO:0071840,GO:0071944,GO:0080090,GO:1901800,GO:1902494,GO:1903050,GO:1903052,GO:1903362,GO:1903364,GO:1905368,GO:1905369 - - - - - - - - - - DUF2587 k59_224415_1 1137281.D778_01413 2.19e-34 125.0 COG0589@1|root,COG0589@2|Bacteria,4NFZ5@976|Bacteroidetes,1HYE4@117743|Flavobacteriia 976|Bacteroidetes T Universal stress protein - - - - - - - - - - - - Usp k59_224415_2 1121912.AUHD01000001_gene2725 3.86e-34 123.0 COG2836@1|root,COG2836@2|Bacteria,4NF84@976|Bacteroidetes,1HXIX@117743|Flavobacteriia 976|Bacteroidetes S Cytochrome c biogenesis protein - - - ko:K09792 - - - - ko00000 - - - DsbD_2 k59_1184622_1 247634.GPB2148_3047 1.27e-46 172.0 COG3164@1|root,COG3164@2|Bacteria,1MXWF@1224|Proteobacteria,1RNUK@1236|Gammaproteobacteria,1J61D@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Protein of unknown function yhdP GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0030288,GO:0030313,GO:0031224,GO:0031226,GO:0031975,GO:0042597,GO:0044425,GO:0044459,GO:0044464,GO:0071944 - - - - - - - - - - AsmA_2,DUF3971 k59_167267_1 1044.EH31_16760 3.3e-155 454.0 COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,2TSYQ@28211|Alphaproteobacteria,2K1U5@204457|Sphingomonadales 204457|Sphingomonadales O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins ftsH - - ko:K03798 - M00742 - - ko00000,ko00002,ko01000,ko01002,ko03110 - - - AAA,FtsH_ext,Peptidase_M41 k59_956249_1 1123279.ATUS01000001_gene1934 1.95e-79 256.0 COG0323@1|root,COG0323@2|Bacteria,1MV61@1224|Proteobacteria,1RM89@1236|Gammaproteobacteria,1J50B@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex mutL GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - ko:K03572 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - DNA_mis_repair,HATPase_c_3,MutL_C k59_224464_1 228405.HNE_0289 8e-39 142.0 COG1846@1|root,COG1846@2|Bacteria,1RETW@1224|Proteobacteria,2UQEX@28211|Alphaproteobacteria 28211|Alphaproteobacteria K Transcriptional regulator - - - - - - - - - - - - - k59_956263_1 1205680.CAKO01000038_gene1958 4.31e-08 54.3 COG0625@1|root,COG0625@2|Bacteria,1REDI@1224|Proteobacteria,2TR9W@28211|Alphaproteobacteria,2JRYS@204441|Rhodospirillales 204441|Rhodospirillales O Belongs to the GST superfamily - - 2.5.1.18 ko:K00799 ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418 - R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905 RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944 ko00000,ko00001,ko01000,ko02000 1.A.12.2.2,1.A.12.3.2 - - GST_C,GST_N,GST_N_3 k59_448019_1 1000565.METUNv1_02453 2.31e-36 132.0 COG1716@1|root,COG1716@2|Bacteria,1MW1M@1224|Proteobacteria,2VJ1K@28216|Betaproteobacteria,2KUV6@206389|Rhodocyclales 206389|Rhodocyclales T (FHA) domain - - - - - - - - - - - - FHA k59_1748914_1 1122137.AQXF01000005_gene1259 3.76e-112 337.0 COG4799@1|root,COG4799@2|Bacteria,1MVAX@1224|Proteobacteria,2TRV6@28211|Alphaproteobacteria 28211|Alphaproteobacteria I acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) MA20_22955 - 6.4.1.5 ko:K13778 ko00281,map00281 - R03494 RC00367,RC00942 ko00000,ko00001,ko01000 - - - Carboxyl_trans k59_1803162_2 479432.Sros_8218 1.8e-07 57.8 COG2124@1|root,COG2124@2|Bacteria,2GKCG@201174|Actinobacteria,4EFPE@85012|Streptosporangiales 201174|Actinobacteria Q Cytochrome P450 - - 1.14.13.141 ko:K15981 ko00984,ko01120,map00984,map01120 - R09859,R11357 RC01216,RC03368 ko00000,ko00001,ko00199,ko01000 - - - p450 k59_1242589_1 408672.NBCG_01095 7.38e-31 125.0 COG0318@1|root,COG0318@2|Bacteria,2GIUC@201174|Actinobacteria,4DPQN@85009|Propionibacteriales 201174|Actinobacteria IQ AMP-binding enzyme C-terminal domain - - 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding,AMP-binding_C k59_1693954_1 471854.Dfer_4857 8.91e-32 130.0 COG0577@1|root,COG0577@2|Bacteria,4NDUK@976|Bacteroidetes,47JJN@768503|Cytophagia 976|Bacteroidetes V FtsX-like permease family - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_1693954_2 627192.SLG_27110 1.71e-05 47.8 COG0577@1|root,COG0577@2|Bacteria,1NREW@1224|Proteobacteria,2U1KH@28211|Alphaproteobacteria,2K128@204457|Sphingomonadales 204457|Sphingomonadales V MacB-like periplasmic core domain - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_1750724_1 999141.GME_13928 1.41e-77 243.0 COG0667@1|root,COG0667@2|Bacteria,1MV2Y@1224|Proteobacteria,1RNXH@1236|Gammaproteobacteria,1XIVQ@135619|Oceanospirillales 135619|Oceanospirillales C Aldo keto reductase tas - - - - - - - - - - - Aldo_ket_red k59_1750724_2 1122137.AQXF01000002_gene551 3.8e-08 52.8 COG1247@1|root,COG1247@2|Bacteria,1QXZI@1224|Proteobacteria,2TXES@28211|Alphaproteobacteria 28211|Alphaproteobacteria M Acetyltransferase (GNAT) family - - - - - - - - - - - - Acetyltransf_1 k59_629821_2 1128421.JAGA01000003_gene3142 2.26e-41 148.0 COG0758@1|root,COG0758@2|Bacteria,2NP2V@2323|unclassified Bacteria 2|Bacteria LU DNA recombination-mediator protein A dprA - 5.99.1.2 ko:K03168,ko:K04096 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_processg_A k59_1026111_2 1121430.JMLG01000030_gene1609 1.28e-57 187.0 COG0214@1|root,COG0214@2|Bacteria,1TPSZ@1239|Firmicutes,248C1@186801|Clostridia,25ZYC@186807|Peptococcaceae 186801|Clostridia H Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively pdxS - 4.3.3.6 ko:K06215 ko00750,map00750 - R07456 RC00010,RC01783,RC03043 ko00000,ko00001,ko01000 - - - SOR_SNZ k59_1534003_1 1157490.EL26_13260 3.69e-05 53.5 COG3857@1|root,COG3857@2|Bacteria,1TVKS@1239|Firmicutes,4I3G1@91061|Bacilli,278HN@186823|Alicyclobacillaceae 91061|Bacilli L PD-(D/E)XK nuclease superfamily - - - - - - - - - - - - PDDEXK_1 k59_461739_1 682795.AciX8_2135 9.94e-13 73.9 COG0043@1|root,COG0043@2|Bacteria,3Y3BY@57723|Acidobacteria,2JHTW@204432|Acidobacteriia 204432|Acidobacteriia H Belongs to the UbiD family - - 4.1.1.98 ko:K03182 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00117 R04985,R04986 RC00391 ko00000,ko00001,ko00002,ko01000 - - - UbiD k59_969694_2 67356.KL575597_gene7672 1.01e-140 407.0 COG4653@1|root,COG4653@2|Bacteria,2I9E6@201174|Actinobacteria 201174|Actinobacteria S Phage capsid family - - - - - - - - - - - - Phage_capsid k59_179249_1 203122.Sde_2809 6.65e-40 154.0 COG3507@1|root,COG3507@2|Bacteria,1R4H2@1224|Proteobacteria,1SXV5@1236|Gammaproteobacteria,469KM@72275|Alteromonadaceae 1236|Gammaproteobacteria G Ricin-type beta-trefoil - - 3.2.1.99 ko:K06113 - - - - ko00000,ko01000 - GH43 - RicinB_lectin_2 k59_574639_2 582744.Msip34_1064 2.41e-22 99.0 COG2199@1|root,COG3706@2|Bacteria,1MZV7@1224|Proteobacteria,2VMSZ@28216|Betaproteobacteria,2KMS6@206350|Nitrosomonadales 206350|Nitrosomonadales T diguanylate cyclase - - - - - - - - - - - - GGDEF k59_1761147_1 1229909.NSED_02635 1.04e-14 75.9 COG0784@1|root,arCOG02391@2157|Archaea 2157|Archaea T response regulator, receiver - - - ko:K03413 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko02022,ko02035 - - - Response_reg k59_857754_1 234267.Acid_6250 1.55e-102 304.0 COG2382@1|root,COG2382@2|Bacteria 2|Bacteria P enterobactin catabolic process - - - ko:K07214 - - - - ko00000 - - - Esterase k59_517970_2 443255.SCLAV_5085 2.11e-65 209.0 COG0500@1|root,COG2226@2|Bacteria,2GK7A@201174|Actinobacteria 201174|Actinobacteria Q methyltransferase - - - - - - - - - - - - Methyltransf_11,Methyltransf_31 k59_913695_1 436308.Nmar_1696 8e-89 267.0 COG0778@1|root,arCOG00288@2157|Archaea 2157|Archaea C Nitroreductase - - - - - - - - - - - - Nitroreductase k59_913695_2 436308.Nmar_0232 8.73e-26 98.6 COG1371@1|root,arCOG04055@2157|Archaea,41SU0@651137|Thaumarchaeota 651137|Thaumarchaeota S Archease protein family (MTH1598/TM1083) - - - - - - - - - - - - Archease k59_1196244_2 1178482.BJB45_19395 1.35e-16 84.0 COG0591@1|root,COG0591@2|Bacteria,1MUBI@1224|Proteobacteria,1T3SF@1236|Gammaproteobacteria,1XP4Q@135619|Oceanospirillales 135619|Oceanospirillales E Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family - - - - - - - - - - - - SSF k59_574647_1 795666.MW7_2454 1.39e-80 264.0 COG0243@1|root,COG3383@1|root,COG0243@2|Bacteria,COG3383@2|Bacteria,1MW3N@1224|Proteobacteria,2VJG2@28216|Betaproteobacteria,1K5NF@119060|Burkholderiaceae 28216|Betaproteobacteria C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family fdhA - 1.17.1.9 ko:K00123 ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200 - R00519 RC02796 ko00000,ko00001,ko01000 - - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding k59_1761158_1 1121897.AUGO01000008_gene2608 8.04e-71 231.0 COG2885@1|root,COG2885@2|Bacteria,4NE6G@976|Bacteroidetes,1HXNY@117743|Flavobacteriia,2NSMW@237|Flavobacterium 976|Bacteroidetes M Belongs to the ompA family - - - - - - - - - - - - CarboxypepD_reg,OmpA,PD40 k59_1252956_1 886293.Sinac_4407 5.65e-58 193.0 COG0438@1|root,COG0438@2|Bacteria 2|Bacteria M transferase activity, transferring glycosyl groups - - - - - - - - - - - - Glycos_transf_1 k59_1196246_1 1050202.KB913024_gene970 2.11e-10 62.8 COG3502@1|root,COG3542@1|root,COG3502@2|Bacteria,COG3542@2|Bacteria,2IFG5@201174|Actinobacteria,4080G@622450|Actinopolysporales 201174|Actinobacteria S Cupin superfamily (DUF985) - - - ko:K09705 - - - - ko00000 - - - Cupin_5,DUF952 k59_1196246_2 1131269.AQVV01000021_gene2167 8.66e-43 150.0 COG0500@1|root,COG2226@2|Bacteria 2|Bacteria Q methyltransferase - - - - - - - - - - - - Methyltransf_11,Methyltransf_25 k59_913698_1 436308.Nmar_0652 9.44e-135 389.0 COG4608@1|root,arCOG00184@2157|Archaea,41S9E@651137|Thaumarchaeota 651137|Thaumarchaeota E Oligopeptide/dipeptide transporter, C-terminal region - - - ko:K02032 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - ABC_tran,oligo_HPY k59_631181_1 1042375.AFPL01000054_gene2126 3.2e-37 146.0 COG3501@1|root,COG3501@2|Bacteria,1MU7Q@1224|Proteobacteria,1RMZS@1236|Gammaproteobacteria,465CI@72275|Alteromonadaceae 1236|Gammaproteobacteria S protein conserved in bacteria - - - ko:K11904 ko03070,map03070 M00334 - - ko00000,ko00001,ko00002,ko02044 3.A.23.1 - - Phage_GPD k59_1252957_2 263820.PTO0201 1.06e-13 72.8 COG1131@1|root,arCOG00194@2157|Archaea,2XT7Q@28890|Euryarchaeota,2424W@183967|Thermoplasmata 183967|Thermoplasmata V AAA domain, putative AbiEii toxin, Type IV TA system - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_1535194_2 1122137.AQXF01000003_gene2318 3.86e-187 526.0 COG0142@1|root,COG0142@2|Bacteria,1MUK6@1224|Proteobacteria,2TSDZ@28211|Alphaproteobacteria 28211|Alphaproteobacteria H Belongs to the FPP GGPP synthase family ispB GO:0003674,GO:0003824,GO:0004659,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006066,GO:0006629,GO:0006720,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009108,GO:0009987,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0042180,GO:0042181,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901615,GO:1901617,GO:1901661,GO:1901663 2.5.1.90 ko:K02523 ko00900,ko01110,map00900,map01110 - R09248 RC00279 ko00000,ko00001,ko01000,ko01006 - - - polyprenyl_synt k59_1309495_1 2340.JV46_13800 4.37e-46 151.0 COG1393@1|root,COG1393@2|Bacteria,1MZ4Z@1224|Proteobacteria,1S8XH@1236|Gammaproteobacteria,1J6QP@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C COG1393 Arsenate reductase and related proteins, glutaredoxin family arsC - 1.20.4.1 ko:K00537 - - - - ko00000,ko01000 - - - ArsC k59_1309495_2 1123354.AUDR01000015_gene432 0.000154 43.1 COG1838@1|root,COG1951@1|root,COG1838@2|Bacteria,COG1951@2|Bacteria,1MUV9@1224|Proteobacteria,2VIP7@28216|Betaproteobacteria 28216|Betaproteobacteria C Catalyzes the reversible hydration of fumarate to (S)- malate fumA - 4.2.1.2 ko:K01676 ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00173,M00374 R01082 RC00443 ko00000,ko00001,ko00002,ko01000 - - - Fumerase,Fumerase_C k59_574654_1 243233.MCA2573 1.42e-159 476.0 COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,1RNBG@1236|Gammaproteobacteria,1XEFJ@135618|Methylococcales 135618|Methylococcales L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity polA - 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1 k59_1761169_1 983544.Lacal_1696 3.32e-92 279.0 COG0836@1|root,COG0836@2|Bacteria,4NE1Y@976|Bacteroidetes,1HXFU@117743|Flavobacteriia 976|Bacteroidetes M mannose-1-phosphate guanylyltransferase manC - 2.7.7.13 ko:K00971 ko00051,ko00520,ko01100,ko01110,map00051,map00520,map01100,map01110 M00114,M00361,M00362 R00885 RC00002 ko00000,ko00001,ko00002,ko01000 - - - NTP_transferase k59_969712_2 1088721.NSU_4393 1.66e-51 167.0 COG1825@1|root,COG1825@2|Bacteria,1RDH0@1224|Proteobacteria,2U5P0@28211|Alphaproteobacteria,2K122@204457|Sphingomonadales 204457|Sphingomonadales J This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance ctc - - ko:K02897 ko03010,map03010 M00178 - - ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L25p,Ribosomal_TL5_C k59_292731_1 1500890.JQNL01000001_gene38 1.69e-16 85.9 COG4773@1|root,COG4773@2|Bacteria,1QTXJ@1224|Proteobacteria,1T2I5@1236|Gammaproteobacteria,1X59N@135614|Xanthomonadales 135614|Xanthomonadales P TonB dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_801224_1 665029.EAMY_2578 1.35e-71 229.0 COG0124@1|root,COG0124@2|Bacteria,1MV2K@1224|Proteobacteria,1RPHI@1236|Gammaproteobacteria,3X5JY@551|Erwinia 1236|Gammaproteobacteria J Histidyl-tRNA synthetase hisS GO:0003674,GO:0003824,GO:0004812,GO:0004821,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006427,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.21 ko:K01892 ko00970,map00970 M00359,M00360 R03655 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iE2348C_1286.E2348C_2797,iECNA114_1301.ECNA114_2592,iECSF_1327.ECSF_2358 HGTP_anticodon,tRNA-synt_His k59_1704560_1 745411.B3C1_10572 1.02e-36 137.0 COG3852@1|root,COG3852@2|Bacteria,1MVN6@1224|Proteobacteria,1RN15@1236|Gammaproteobacteria,1J4NI@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T Signal transduction histidine kinase, nitrogen specific glnL GO:0000155,GO:0000160,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0004721,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0006464,GO:0006468,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016311,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0016787,GO:0016788,GO:0016791,GO:0018106,GO:0018193,GO:0018202,GO:0019222,GO:0019538,GO:0023014,GO:0023052,GO:0035556,GO:0036211,GO:0042578,GO:0042802,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0046777,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051716,GO:0065007,GO:0071704,GO:0140096,GO:1901564 2.7.13.3 ko:K07708 ko02020,map02020 M00497 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA,PAS,PAS_4 k59_1704560_2 398579.Spea_3928 1.08e-18 85.5 2E42P@1|root,32YZ5@2|Bacteria,1N868@1224|Proteobacteria,1SCUM@1236|Gammaproteobacteria,2QBX8@267890|Shewanellaceae 1236|Gammaproteobacteria S Domain of unknown function (DUF4124) - - - - - - - - - - - - BiPBP_C,DUF4124 k59_1591380_1 156889.Mmc1_2372 8.55e-29 117.0 COG1629@1|root,COG4771@2|Bacteria,1MUC1@1224|Proteobacteria,2U16R@28211|Alphaproteobacteria 28211|Alphaproteobacteria P TonB-dependent Receptor Plug Domain - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_1196283_1 436308.Nmar_0294 7.5e-86 259.0 COG2520@1|root,arCOG00033@2157|Archaea,41S7P@651137|Thaumarchaeota 651137|Thaumarchaeota J Met-10+ like-protein - - 2.1.1.228 ko:K15429 - - R00597 RC00003,RC00334 ko00000,ko01000,ko03016 - - - Met_10 k59_1083177_1 926569.ANT_26430 3.24e-59 204.0 COG0577@1|root,COG4591@1|root,COG0577@2|Bacteria,COG4591@2|Bacteria,2G6IW@200795|Chloroflexi 200795|Chloroflexi V MacB-like periplasmic core domain - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_179296_1 55601.VANGNB10_cI0017c 9.83e-20 89.4 COG0751@1|root,COG0751@2|Bacteria,1MV2F@1224|Proteobacteria,1RNR3@1236|Gammaproteobacteria,1XT5T@135623|Vibrionales 135623|Vibrionales J Glycyl-tRNA synthetase beta subunit glyS GO:0003674,GO:0003824,GO:0004812,GO:0004820,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006426,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.14 ko:K01879 ko00970,map00970 M00360 R03654 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DALR_1,tRNA_synt_2f k59_179296_2 765910.MARPU_16645 2.93e-25 103.0 COG0204@1|root,COG0204@2|Bacteria,1MY51@1224|Proteobacteria,1RQYC@1236|Gammaproteobacteria,1WXP3@135613|Chromatiales 135613|Chromatiales I PFAM Phospholipid glycerol acyltransferase - - 2.3.1.51 ko:K00655 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R02241,R09381 RC00004,RC00037,RC00039 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Acyltransferase k59_1027570_2 1336245.JAGO01000012_gene1690 2.37e-21 91.7 COG4149@1|root,COG4149@2|Bacteria,1MUXR@1224|Proteobacteria,1RRDV@1236|Gammaproteobacteria,1XJ75@135619|Oceanospirillales 135619|Oceanospirillales P (ABC) transporter modB - - ko:K02018 ko02010,map02010 M00189 - - ko00000,ko00001,ko00002,ko02000 3.A.1.8 - - BPD_transp_1 k59_1479315_1 443144.GM21_3412 6.85e-40 151.0 COG1663@1|root,COG1663@2|Bacteria,1MU8G@1224|Proteobacteria,42PA2@68525|delta/epsilon subdivisions,2WNJ4@28221|Deltaproteobacteria,43SX0@69541|Desulfuromonadales 28221|Deltaproteobacteria F Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) lpxK - 2.7.1.130 ko:K00912 ko00540,ko01100,map00540,map01100 M00060 R04657 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000,ko01005 - - - LpxK k59_1365982_1 3988.XP_002538806.1 1.85e-10 63.2 COG1680@1|root,2QQBX@2759|Eukaryota 2759|Eukaryota V regulation of lipid metabolic process - - - - - - - - - - - - Beta-lactamase,DAP_B k59_1309525_1 398525.KB900702_gene251 2.3e-44 158.0 COG3335@1|root,COG3335@2|Bacteria,1MW7X@1224|Proteobacteria,2TTH8@28211|Alphaproteobacteria,3JWD8@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria L DDE superfamily endonuclease - - - - - - - - - - - - DDE_3,HTH_23,HTH_29,HTH_32 k59_1648254_1 1096930.L284_10280 1.66e-59 204.0 COG0187@1|root,COG0187@2|Bacteria,1MVKT@1224|Proteobacteria,2TRBK@28211|Alphaproteobacteria,2K0E4@204457|Sphingomonadales 204457|Sphingomonadales L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrB - 5.99.1.3 ko:K02470 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim k59_349351_1 1479623.JHEL01000014_gene2186 1.34e-71 235.0 COG0187@1|root,COG0187@2|Bacteria,2GKGP@201174|Actinobacteria,4FMXF@85023|Microbacteriaceae 201174|Actinobacteria L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrB GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0003916,GO:0003918,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006265,GO:0006725,GO:0006807,GO:0006996,GO:0007059,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0009295,GO:0009987,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017076,GO:0017111,GO:0030312,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034335,GO:0034641,GO:0035639,GO:0036094,GO:0040007,GO:0042623,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0046872,GO:0051276,GO:0061505,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:0097367,GO:0140097,GO:1901265,GO:1901360,GO:1901363 5.99.1.3 ko:K02470 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim k59_179317_1 1280944.HY17_14965 3.91e-106 331.0 COG2844@1|root,COG2844@2|Bacteria,1MV54@1224|Proteobacteria,2TSV0@28211|Alphaproteobacteria,43WNX@69657|Hyphomonadaceae 28211|Alphaproteobacteria O Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen glnD GO:0006355,GO:0006464,GO:0006807,GO:0006808,GO:0007154,GO:0007584,GO:0008150,GO:0008152,GO:0009605,GO:0009719,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0009991,GO:0010033,GO:0010243,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0018175,GO:0018177,GO:0019219,GO:0019222,GO:0019538,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031667,GO:0031668,GO:0031669,GO:0031670,GO:0036211,GO:0042221,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051716,GO:0060255,GO:0065007,GO:0070887,GO:0071310,GO:0071417,GO:0071495,GO:0071496,GO:0071704,GO:0080090,GO:0090293,GO:1901564,GO:1901698,GO:1901699,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141 2.7.7.59 ko:K00990 ko02020,map02020 - - - ko00000,ko00001,ko01000 - - - ACT,GlnD_UR_UTase,GlnE,HD,NTP_transf_2 k59_292769_1 1229909.NSED_09045 1.24e-90 271.0 arCOG08770@1|root,arCOG08770@2157|Archaea,41T2S@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_10145_1 1121013.P873_03040 3.1e-45 169.0 COG4262@1|root,COG4262@2|Bacteria,1QXYI@1224|Proteobacteria,1T3KR@1236|Gammaproteobacteria,1X8H2@135614|Xanthomonadales 135614|Xanthomonadales S Spermine/spermidine synthase domain - - - - - - - - - - - - Spermine_synth k59_857855_1 221988.MS1671 3.59e-29 121.0 COG0770@1|root,COG0770@2|Bacteria,1QTSF@1224|Proteobacteria,1RMGD@1236|Gammaproteobacteria,1Y7Y6@135625|Pasteurellales 135625|Pasteurellales M Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein murF - 6.3.2.10 ko:K01929 ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502 - R04573,R04617 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_1704606_1 1429916.X566_14890 2.13e-132 382.0 COG0179@1|root,COG0179@2|Bacteria,1R7SI@1224|Proteobacteria,2VFC0@28211|Alphaproteobacteria,3K3FV@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria Q Fumarylacetoacetate (FAA) hydrolase family - - - - - - - - - - - - FAA_hydrolase k59_1253008_1 1229909.NSED_04495 1.41e-63 199.0 COG0638@1|root,arCOG00971@2157|Archaea,41SYA@651137|Thaumarchaeota 651137|Thaumarchaeota O Proteasome endopeptidase complex - - 3.4.25.1 ko:K03432 ko03050,map03050 M00342,M00343 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03051 - - - Proteasome,Proteasome_A_N k59_1366005_1 1123228.AUIH01000022_gene3111 3.05e-76 241.0 COG1220@1|root,COG1220@2|Bacteria,1MVK9@1224|Proteobacteria,1RMYV@1236|Gammaproteobacteria,1XI7F@135619|Oceanospirillales 135619|Oceanospirillales O this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis hslU - - ko:K03667 - - - - ko00000,ko03110 - - - AAA_2,ClpB_D2-small k59_857871_1 765912.Thimo_2057 2.79e-110 350.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1WWJ6@135613|Chromatiales 135613|Chromatiales V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_1196371_1 1231185.BAMP01000005_gene3979 6.45e-73 234.0 COG0240@1|root,COG0240@2|Bacteria,1MXI9@1224|Proteobacteria,2TTK4@28211|Alphaproteobacteria,43NIT@69277|Phyllobacteriaceae 28211|Alphaproteobacteria C NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain - - 1.5.1.28 ko:K04940 - - - - ko00000,ko01000 - - - ApbA,F420_oxidored,NAD_Gly3P_dh_N,Octopine_DH k59_1196371_2 1502852.FG94_04179 1.71e-14 82.4 COG1629@1|root,COG1629@2|Bacteria,COG4771@2|Bacteria,1MU9K@1224|Proteobacteria,2WC4X@28216|Betaproteobacteria,47704@75682|Oxalobacteraceae 28216|Betaproteobacteria P TonB dependent receptor - - - - - - - - - - - - Plug,TonB_dep_Rec k59_10159_1 644282.Deba_0121 8.99e-112 338.0 COG0033@1|root,COG0033@2|Bacteria,1MU5S@1224|Proteobacteria,42M9F@68525|delta/epsilon subdivisions,2WJNB@28221|Deltaproteobacteria 28221|Deltaproteobacteria G Phosphoglucomutase phosphomannomutase alpha beta alpha domain I pgm - 5.4.2.2 ko:K01835 ko00010,ko00030,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130 M00549 R00959,R01057,R08639 RC00408 ko00000,ko00001,ko00002,ko01000 - - - PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV k59_292807_1 158500.BV97_02305 1.26e-13 72.0 COG4649@1|root,COG4649@2|Bacteria,1RH7G@1224|Proteobacteria,2UASV@28211|Alphaproteobacteria,2KD7Q@204457|Sphingomonadales 204457|Sphingomonadales S Tetratricopeptide repeat-like domain - - - - - - - - - - - - TPR_21 k59_292807_2 1219035.NT2_01_04100 2.8e-18 84.7 COG0438@1|root,COG0438@2|Bacteria,1MU9C@1224|Proteobacteria,2U43G@28211|Alphaproteobacteria,2K0KR@204457|Sphingomonadales 204457|Sphingomonadales M Glycosyl transferase family 1 - - - - - - - - - - - - Glyco_transf_4,Glycos_transf_1 k59_349391_1 1095769.CAHF01000011_gene2059 1.1e-60 193.0 COG0558@1|root,COG0558@2|Bacteria,1RCZ7@1224|Proteobacteria,2VQI2@28216|Betaproteobacteria,472SR@75682|Oxalobacteraceae 28216|Betaproteobacteria I Belongs to the CDP-alcohol phosphatidyltransferase class-I family pgsA - 2.7.8.41,2.7.8.5 ko:K00995,ko:K08744 ko00564,ko01100,map00564,map01100 - R01801,R02030 RC00002,RC00017,RC02795 ko00000,ko00001,ko01000 - - - CDP-OH_P_transf k59_292811_1 1122137.AQXF01000003_gene1915 6e-86 269.0 COG0477@1|root,COG2814@2|Bacteria,1MU1I@1224|Proteobacteria,2TVXT@28211|Alphaproteobacteria 28211|Alphaproteobacteria EGP Major facilitator Superfamily emrB - - ko:K03446 - M00701 - - ko00000,ko00002,ko02000 2.A.1.3 - - MFS_1 k59_1027634_1 2340.JV46_21860 6.57e-137 424.0 COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,1MV6G@1224|Proteobacteria,1RMYD@1236|Gammaproteobacteria,1J4ZR@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Methionine synthase metH GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006464,GO:0006479,GO:0006520,GO:0006555,GO:0006575,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0008213,GO:0008270,GO:0008276,GO:0008652,GO:0008705,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0019538,GO:0019752,GO:0019842,GO:0031419,GO:0032259,GO:0034641,GO:0035999,GO:0036094,GO:0036211,GO:0042084,GO:0042558,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043414,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046653,GO:0046872,GO:0046906,GO:0046914,GO:0048037,GO:0050667,GO:0051186,GO:0071704,GO:0097159,GO:0140096,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.1.1.13 ko:K00548 ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230 M00017 R00946,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 - - iECO103_1326.ECO103_4764,iECUMN_1333.ECUMN_4545 B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans k59_969823_1 243231.GSU3451 2.52e-46 160.0 COG1073@1|root,COG1073@2|Bacteria,1RIWI@1224|Proteobacteria,42TGK@68525|delta/epsilon subdivisions,2WRBS@28221|Deltaproteobacteria,43VRI@69541|Desulfuromonadales 28221|Deltaproteobacteria S Alpha/beta hydrolase family - - - ko:K06889 - - - - ko00000 - - - Hydrolase_4 k59_405405_1 1331060.RLDS_04600 4e-29 119.0 COG3104@1|root,COG3104@2|Bacteria,1MW6W@1224|Proteobacteria,2U15C@28211|Alphaproteobacteria,2K05X@204457|Sphingomonadales 204457|Sphingomonadales E amino acid peptide transporter - - - ko:K03305 - - - - ko00000 2.A.17 - - PTR2 k59_1253031_1 84531.JMTZ01000011_gene3046 1.62e-57 187.0 COG0755@1|root,COG0755@2|Bacteria,1MU61@1224|Proteobacteria,1RP3R@1236|Gammaproteobacteria,1X357@135614|Xanthomonadales 135614|Xanthomonadales O Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes ccmC - - ko:K02195 ko02010,map02010 M00259 - - ko00000,ko00001,ko00002,ko02000 3.A.1.107 - - Cytochrom_C_asm k59_801287_1 1274524.BSONL12_14016 1.52e-24 96.7 COG2172@1|root,COG2172@2|Bacteria,1V6Y4@1239|Firmicutes,4HIQU@91061|Bacilli,1ZG7T@1386|Bacillus 91061|Bacilli T COG2172 Anti-sigma regulatory factor (Ser Thr protein kinase) rsbT - 2.7.11.1 ko:K17752 - - - - ko00000,ko01000,ko01001,ko03021 - - - HATPase_c,HATPase_c_2 k59_801287_2 1121447.JONL01000001_gene929 1.32e-19 89.4 COG2208@1|root,COG2208@2|Bacteria,1R1UF@1224|Proteobacteria 1224|Proteobacteria KT phosphoserine phosphatase activity - - - - - - - - - - - - - k59_292825_1 1122137.AQXF01000001_gene2854 7.4e-13 70.1 COG1477@1|root,COG1477@2|Bacteria 2|Bacteria H protein flavinylation apbE - 2.7.1.180 ko:K03734 - - - - ko00000,ko01000 - - - ApbE k59_292825_2 306281.AJLK01000025_gene1695 1.06e-65 209.0 COG0625@1|root,COG0625@2|Bacteria,1G1XI@1117|Cyanobacteria,1JJZF@1189|Stigonemataceae 1117|Cyanobacteria O Glutathione S-transferase, N-terminal domain - - 2.5.1.18 ko:K00799 ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418 - R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905 RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944 ko00000,ko00001,ko01000,ko02000 1.A.12.2.2,1.A.12.3.2 - - GST_C_2,GST_C_3,GST_N,GST_N_3 k59_10188_1 1177154.Y5S_01714 1.31e-80 260.0 COG0457@1|root,COG0457@2|Bacteria,1MXSS@1224|Proteobacteria,1S157@1236|Gammaproteobacteria,1XQ5M@135619|Oceanospirillales 1236|Gammaproteobacteria S Tetratricopeptide repeat - - - - - - - - - - - - TPR_16 k59_518092_1 1313172.YM304_14720 2.52e-95 301.0 COG1770@1|root,COG1770@2|Bacteria,2GNA9@201174|Actinobacteria,4CMWJ@84992|Acidimicrobiia 84992|Acidimicrobiia E Prolyl oligopeptidase, N-terminal beta-propeller domain ptrB - 3.4.21.83 ko:K01354 ko05142,ko05143,map05142,map05143 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_S9,Peptidase_S9_N k59_1262467_1 180332.JTGN01000006_gene3354 2.79e-05 51.6 COG2804@1|root,COG2804@2|Bacteria,1TPGE@1239|Firmicutes,247KA@186801|Clostridia 186801|Clostridia NU type II secretion system protein E - - - ko:K02652 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE,T2SSE_N k59_303333_1 436308.Nmar_0653 1.49e-10 60.8 COG4301@1|root,arCOG06722@2157|Archaea,41SWR@651137|Thaumarchaeota 651137|Thaumarchaeota S Histidine-specific methyltransferase, SAM-dependent - - - - - - - - - - - - Methyltransf_33 k59_303333_2 436308.Nmar_0652 4.01e-62 200.0 COG4608@1|root,arCOG00184@2157|Archaea,41S9E@651137|Thaumarchaeota 651137|Thaumarchaeota E Oligopeptide/dipeptide transporter, C-terminal region - - - ko:K02032 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - ABC_tran,oligo_HPY k59_979458_2 391589.RGAI101_4073 2.71e-97 304.0 COG1236@1|root,COG1236@2|Bacteria,1MUDD@1224|Proteobacteria,2TVFM@28211|Alphaproteobacteria 28211|Alphaproteobacteria J exonuclease of the beta-lactamase fold involved in RNA processing - - - ko:K07576 - - - - ko00000 - - - Beta-Casp,Lactamase_B,Lactamase_B_2,RMMBL k59_1714883_1 1229909.NSED_03305 1.65e-73 226.0 arCOG08669@1|root,arCOG08669@2157|Archaea,41SEB@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1319700_1 1088721.NSU_1845 3.82e-142 407.0 COG2010@1|root,COG2010@2|Bacteria,1MUCW@1224|Proteobacteria,2TQW1@28211|Alphaproteobacteria,2K23A@204457|Sphingomonadales 204457|Sphingomonadales C C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex - - - ko:K00406 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00156 - - ko00000,ko00001,ko00002 3.D.4.3 - - Cytochrom_C,Cytochrome_CBB3,FixP_N k59_303345_1 426117.M446_6351 9.55e-70 221.0 COG0451@1|root,COG0451@2|Bacteria,1MW32@1224|Proteobacteria,2TTTU@28211|Alphaproteobacteria,1JT4M@119045|Methylobacteriaceae 28211|Alphaproteobacteria M PFAM NAD-dependent epimerase dehydratase dfrA - 1.1.1.219 ko:K00091 - - - - ko00000,ko01000 - - - Epimerase k59_1262482_1 85643.Tmz1t_2955 8.98e-54 187.0 COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,1NBSJ@1224|Proteobacteria,2VIEB@28216|Betaproteobacteria,2KY1I@206389|Rhodocyclales 206389|Rhodocyclales C Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg - - 1.2.7.11,1.2.7.3 ko:K00174 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - POR,POR_N k59_1602110_1 1041522.MCOL_V225777 2.63e-75 233.0 2EX42@1|root,33PSN@2|Bacteria,2I9KB@201174|Actinobacteria,235YV@1762|Mycobacteriaceae 201174|Actinobacteria - - - - - - - - - - - - - - - k59_1659054_2 1089550.ATTH01000001_gene316 5.12e-27 110.0 COG3222@1|root,COG3222@2|Bacteria,4NM7F@976|Bacteroidetes,1FK4V@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes S Uncharacterized protein conserved in bacteria (DUF2064) - - - ko:K09931 - - - - ko00000 - - - DUF2064 k59_1659054_3 1347086.CCBA010000030_gene305 5.34e-11 62.4 29RJN@1|root,30CNU@2|Bacteria,1UA58@1239|Firmicutes,4IKFQ@91061|Bacilli,1ZGVS@1386|Bacillus 91061|Bacilli - - - - - - - - - - - - - - - k59_20413_1 1122194.AUHU01000016_gene1841 1.06e-107 322.0 COG0001@1|root,COG0001@2|Bacteria,1MUY5@1224|Proteobacteria,1RM7N@1236|Gammaproteobacteria,463YV@72275|Alteromonadaceae 1236|Gammaproteobacteria H Glutamate-1-semialdehyde aminotransferase hemL GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006725,GO:0006778,GO:0006779,GO:0006782,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016853,GO:0016866,GO:0016869,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042286,GO:0042440,GO:0042802,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046483,GO:0046501,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 5.4.3.8 ko:K01845 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R02272 RC00677 ko00000,ko00001,ko00002,ko01000,ko01007 - - iUMNK88_1353.UMNK88_158 Aminotran_3 k59_303365_1 400668.Mmwyl1_2457 2.34e-88 273.0 COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,1RMBQ@1236|Gammaproteobacteria,1XHTH@135619|Oceanospirillales 135619|Oceanospirillales C Aldehyde dehydrogenase family - - 1.2.1.16,1.2.1.20,1.2.1.79 ko:K00135 ko00250,ko00310,ko00350,ko00650,ko00760,ko01100,ko01120,map00250,map00310,map00350,map00650,map00760,map01100,map01120 M00027 R00713,R00714,R02401 RC00080 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_584979_1 436308.Nmar_1028 7.66e-116 340.0 COG1250@1|root,arCOG00249@2157|Archaea,41S92@651137|Thaumarchaeota 651137|Thaumarchaeota I 3-hydroxyacyl-CoA dehydrogenase - - 1.1.1.35,4.2.1.17 ko:K15016 ko00720,ko01120,ko01200,map00720,map01120,map01200 M00374,M00375 R01975,R03026 RC00117,RC00831 ko00000,ko00001,ko00002,ko01000 - - - 3HCDH,3HCDH_N k59_811419_1 404589.Anae109_0597 2.09e-126 375.0 COG0364@1|root,COG0364@2|Bacteria,1MUN0@1224|Proteobacteria,42M0J@68525|delta/epsilon subdivisions,2WK1D@28221|Deltaproteobacteria 28221|Deltaproteobacteria G Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone zwf - 1.1.1.363,1.1.1.49 ko:K00036 ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230 M00004,M00006,M00008 R00835,R02736,R10907 RC00001,RC00066 ko00000,ko00001,ko00002,ko01000,ko04147 - - - G6PD_C,G6PD_N,Glyco_hydro_2 k59_1206675_1 365046.Rta_02870 2.61e-79 246.0 COG5544@1|root,COG5544@2|Bacteria,1R35W@1224|Proteobacteria,2VR90@28216|Betaproteobacteria,4AHHK@80864|Comamonadaceae 28216|Betaproteobacteria S Predicted periplasmic lipoprotein (DUF2279) - - - - - - - - - - - - DUF2279 k59_359932_1 1218075.BAYA01000011_gene3515 1.76e-67 216.0 COG0324@1|root,COG0324@2|Bacteria,1MUB2@1224|Proteobacteria,2VHEP@28216|Betaproteobacteria,1K1TT@119060|Burkholderiaceae 28216|Betaproteobacteria J Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) miaA - 2.5.1.75 ko:K00791 ko00908,ko01100,ko01110,map00908,map01100,map01110 - R01122 RC02820 ko00000,ko00001,ko01000,ko01006,ko03016 - - - IPPT k59_245926_2 411467.BACCAP_03778 6.04e-57 189.0 COG0391@1|root,COG0391@2|Bacteria 2|Bacteria S phosphotransferase activity, for other substituted phosphate groups cofD - 2.7.8.28 ko:K11212 ko00680,ko01120,map00680,map01120 M00378 R09398 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - UPF0052 k59_1038285_1 460265.Mnod_1653 9.62e-87 259.0 COG0625@1|root,COG0625@2|Bacteria,1MUN3@1224|Proteobacteria,2TTVR@28211|Alphaproteobacteria,1JSF7@119045|Methylobacteriaceae 28211|Alphaproteobacteria O Belongs to the GST superfamily - - - ko:K11209 - - - - ko00000,ko01000 - - - GST_C,GST_N k59_1038285_2 641524.ADICYQ_4517 0.0006 42.0 COG1225@1|root,COG1225@2|Bacteria,4NKV2@976|Bacteroidetes,47Q4V@768503|Cytophagia 976|Bacteroidetes O Redoxin - - - - - - - - - - - - AhpC-TSA k59_415390_1 1517416.IDAT_03570 3.4e-71 239.0 COG1629@1|root,COG1629@2|Bacteria,COG4771@2|Bacteria,1MU9K@1224|Proteobacteria,1RMTG@1236|Gammaproteobacteria,2QEY1@267893|Idiomarinaceae 1236|Gammaproteobacteria P TonB dependent receptor - - - - - - - - - - - - Plug,TonB_dep_Rec k59_77823_1 1254432.SCE1572_22185 8.88e-85 265.0 COG0518@1|root,COG0519@1|root,COG0518@2|Bacteria,COG0519@2|Bacteria,1MU2A@1224|Proteobacteria,42M0I@68525|delta/epsilon subdivisions,2WJ6D@28221|Deltaproteobacteria,2YTZV@29|Myxococcales 28221|Deltaproteobacteria F Catalyzes the synthesis of GMP from XMP guaA GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046037,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 6.3.5.2 ko:K01951 ko00230,ko00983,ko01100,map00230,map00983,map01100 M00050 R01230,R01231,R08244 RC00010,RC00204 ko00000,ko00001,ko00002,ko01000,ko01002 - - - GATase,GMP_synt_C,NAD_synthase,tRNA_Me_trans k59_1093290_1 861299.J421_2719 4.91e-59 197.0 COG0213@1|root,COG0213@2|Bacteria,1ZTBE@142182|Gemmatimonadetes 142182|Gemmatimonadetes F Pyrimidine nucleoside phosphorylase C-terminal domain - - 2.4.2.2 ko:K00756 ko00240,ko01100,map00240,map01100 - R01570,R01876,R02296,R02484 RC00063 ko00000,ko00001,ko01000 - - - Glycos_trans_3N,Glycos_transf_3,PYNP_C k59_585008_1 561229.Dd1591_1322 2.07e-49 179.0 COG1020@1|root,COG3319@1|root,COG1020@2|Bacteria,COG3319@2|Bacteria,1QK4F@1224|Proteobacteria,1RPAG@1236|Gammaproteobacteria,2JDCJ@204037|Dickeya 1236|Gammaproteobacteria Q TIGRFAM amino acid adenylation domain protein entF - 6.3.2.14 ko:K02364 ko01053,ko01110,ko01130,map01053,map01110,map01130 - R07644 RC00162,RC03046 ko00000,ko00001,ko01000,ko01008 - - - AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase k59_1376705_1 1122137.AQXF01000002_gene335 2.3e-98 297.0 COG1104@1|root,COG1104@2|Bacteria,1MU1C@1224|Proteobacteria,2TSQE@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins nifS GO:0000096,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005759,GO:0005829,GO:0006082,GO:0006139,GO:0006163,GO:0006464,GO:0006520,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009144,GO:0009150,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0016043,GO:0016226,GO:0016740,GO:0016782,GO:0016783,GO:0018130,GO:0018282,GO:0018283,GO:0019538,GO:0019637,GO:0019693,GO:0019752,GO:0022607,GO:0031071,GO:0031163,GO:0031974,GO:0031981,GO:0032324,GO:0034641,GO:0036211,GO:0042278,GO:0042802,GO:0042803,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043412,GO:0043436,GO:0043545,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044422,GO:0044424,GO:0044428,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046039,GO:0046128,GO:0046483,GO:0046983,GO:0051186,GO:0051188,GO:0051189,GO:0055086,GO:0065003,GO:0070013,GO:0071704,GO:0071840,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657 2.8.1.7 ko:K04487 ko00730,ko01100,ko04122,map00730,map01100,map04122 - R07460,R11528,R11529 RC01789,RC02313 ko00000,ko00001,ko01000,ko02048,ko03016,ko03029 - - - Aminotran_5 k59_1262530_1 1036674.A28LD_2071 5.09e-32 128.0 COG2374@1|root,COG2374@2|Bacteria,1MX52@1224|Proteobacteria,1RMHH@1236|Gammaproteobacteria,2QFVQ@267893|Idiomarinaceae 1236|Gammaproteobacteria S Endonuclease/Exonuclease/phosphatase family - - - ko:K07004 - - - - ko00000 - - - DUF3616,Endonuclease_1,Exo_endo_phos,LTD k59_133381_1 1229909.NSED_06305 8.58e-30 107.0 COG5431@1|root,arCOG01120@2157|Archaea,41SW3@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_133381_2 1229909.NSED_06300 6.28e-26 98.2 arCOG10573@1|root,arCOG10573@2157|Archaea,41T8W@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_190072_1 391625.PPSIR1_16240 3.52e-87 269.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,2YUJ9@29|Myxococcales 28221|Deltaproteobacteria T Response regulator containing CheY-like receiver AAA-type ATPase and DNA-binding domains pilR - - ko:K02667 ko02020,map02020 M00501 - - ko00000,ko00001,ko00002,ko02022,ko02035 - - - HTH_8,Response_reg,Sigma54_activat k59_303423_1 1192034.CAP_8509 2.28e-06 51.2 COG0500@1|root,COG0500@2|Bacteria,1R0DM@1224|Proteobacteria,43CW7@68525|delta/epsilon subdivisions,2X847@28221|Deltaproteobacteria,2Z3KJ@29|Myxococcales 28221|Deltaproteobacteria Q Methyltransferase domain - - - - - - - - - - - - Methyltransf_25 k59_1206715_1 1137281.D778_00886 1.19e-68 208.0 COG0335@1|root,COG0335@2|Bacteria,4NNPW@976|Bacteroidetes,1I1YF@117743|Flavobacteriia 976|Bacteroidetes J This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site rplS GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - ko:K02884 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L19 k59_77851_1 316407.85674885 5.92e-120 348.0 COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,1RNJ1@1236|Gammaproteobacteria,3XNE6@561|Escherichia 1236|Gammaproteobacteria EP probably responsible for the translocation of the substrate across the membrane oppB GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0016020,GO:0022857,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944 - ko:K15581 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00439 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 - - BPD_transp_1 k59_1771266_1 443152.MDG893_02685 0.000255 45.4 COG0515@1|root,COG2199@1|root,COG3899@1|root,COG0515@2|Bacteria,COG3706@2|Bacteria,COG3899@2|Bacteria,1R7HC@1224|Proteobacteria,1T315@1236|Gammaproteobacteria,46AA9@72275|Alteromonadaceae 1236|Gammaproteobacteria T diguanylate cyclase - - - - - - - - - - - - AAA_16,GAF,GGDEF,Pkinase k59_1771266_2 56780.SYN_01374 1.39e-82 269.0 COG2202@1|root,COG3829@1|root,COG4191@1|root,COG2202@2|Bacteria,COG3829@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42PDY@68525|delta/epsilon subdivisions,2WMD0@28221|Deltaproteobacteria 28221|Deltaproteobacteria T Histidine kinase - - - - - - - - - - - - GAF_2,HATPase_c,HisKA,PAS,PAS_4,PAS_8,PAS_9,Response_reg k59_471870_2 34007.IT40_08695 7.6e-09 61.6 COG0600@1|root,COG0600@2|Bacteria,1MWDJ@1224|Proteobacteria,2TRDG@28211|Alphaproteobacteria,2PWFR@265|Paracoccus 28211|Alphaproteobacteria P ABC transporter permease - - - - - - - - - - - - BPD_transp_1 k59_641470_2 436308.Nmar_0519 4.21e-54 170.0 COG1400@1|root,arCOG01217@2157|Archaea,41SR5@651137|Thaumarchaeota 651137|Thaumarchaeota U SRP19 protein - - - ko:K03105 ko03060,map03060 - - - ko00000,ko00001,ko02044 3.A.5.7,3.A.5.9 - - SRP19 k59_641470_3 436308.Nmar_0518 2.16e-39 132.0 COG3277@1|root,arCOG02466@2157|Archaea,41SVG@651137|Thaumarchaeota 651137|Thaumarchaeota J RNA-binding protein involved in rRNA processing - - - ko:K07569 - - - - ko00000,ko03009 - - - Gar1 k59_1546040_1 1121875.KB907546_gene2713 3.03e-31 120.0 COG2610@1|root,COG2610@2|Bacteria,4NFQH@976|Bacteroidetes,1I149@117743|Flavobacteriia 976|Bacteroidetes EG GntP family permease - - - ko:K03299 - - - - ko00000,ko02000 2.A.8 - - GntP_permease k59_1546040_2 926549.KI421517_gene1802 1.71e-115 339.0 COG3970@1|root,COG3970@2|Bacteria,4NGTH@976|Bacteroidetes,47MQU@768503|Cytophagia 976|Bacteroidetes S PFAM fumarylacetoacetate (FAA) hydrolase - - 4.2.1.141 ko:K14259 ko00040,map00040 - R09186 RC00429 ko00000,ko00001,ko01000 - - - FAA_hydrolase k59_585054_1 1123236.KB899376_gene508 8.74e-57 187.0 COG2826@1|root,COG2826@2|Bacteria,1MWI0@1224|Proteobacteria,1RRSE@1236|Gammaproteobacteria,467FY@72275|Alteromonadaceae 1236|Gammaproteobacteria L Integrase core domain - - - - - - - - - - - - HTH_38,rve k59_811463_1 1121937.AUHJ01000008_gene2045 7.1e-116 340.0 COG0408@1|root,COG0408@2|Bacteria,1MWMF@1224|Proteobacteria,1RMM8@1236|Gammaproteobacteria,464YS@72275|Alteromonadaceae 1236|Gammaproteobacteria H Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX hemF GO:0003674,GO:0003824,GO:0004109,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016491,GO:0016627,GO:0016634,GO:0018130,GO:0019438,GO:0030145,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0046872,GO:0046906,GO:0046914,GO:0046983,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 1.3.3.3 ko:K00228 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R03220 RC00884 ko00000,ko00001,ko00002,ko01000 - - iAF1260.b2436,iBWG_1329.BWG_2198,iECDH10B_1368.ECDH10B_2601,iECDH1ME8569_1439.ECDH1ME8569_2370,iETEC_1333.ETEC_2549,iEcDH1_1363.EcDH1_1225,iEcHS_1320.EcHS_A2573,iEcolC_1368.EcolC_1243,iJO1366.b2436,iJR904.b2436,iY75_1357.Y75_RS12760 Coprogen_oxidas k59_190092_1 1335757.SPICUR_02575 1.76e-77 248.0 COG0143@1|root,COG0143@2|Bacteria,1MUBY@1224|Proteobacteria,1RMYM@1236|Gammaproteobacteria,1WWU6@135613|Chromatiales 135613|Chromatiales J Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation metG - 6.1.1.10 ko:K01874 ko00450,ko00970,map00450,map00970 M00359,M00360 R03659,R04773 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,tRNA-synt_1g,tRNA_bind k59_1432113_1 316407.85676004 1.9e-107 330.0 COG0784@1|root,COG2198@1|root,COG5002@1|root,COG0784@2|Bacteria,COG2198@2|Bacteria,COG5002@2|Bacteria,1NC9X@1224|Proteobacteria,1SVEC@1236|Gammaproteobacteria,3XM6K@561|Escherichia 1236|Gammaproteobacteria T Member of the two-component regulatory system ArcB ArcA. Sensor-regulator protein for anaerobic repression of the arc modulon. Activates ArcA via a four-step phosphorelay. ArcB can also dephosphorylate ArcA by a reverse phosphorelay involving His- 717 and Asp-576 arcB GO:0000155,GO:0000160,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009927,GO:0009987,GO:0016020,GO:0016021,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0023014,GO:0023052,GO:0031224,GO:0035556,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044464,GO:0046777,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0060089,GO:0065007,GO:0071704,GO:0071944,GO:0140096,GO:1901564 2.7.13.3 ko:K07648 ko02020,ko02026,map02020,map02026 M00456 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA,Hpt,PAS,PAS_4,Response_reg k59_303456_1 644548.SCNU_07468 1.32e-34 129.0 COG1905@1|root,COG1905@2|Bacteria,2GKG0@201174|Actinobacteria,4GD47@85026|Gordoniaceae 201174|Actinobacteria C Thioredoxin-like [2Fe-2S] ferredoxin nuoE GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0008137,GO:0008150,GO:0008152,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0022900,GO:0022904,GO:0030964,GO:0032991,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0045333,GO:0050136,GO:0055114,GO:0070469,GO:0070470,GO:0071944,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1990204 1.6.5.3 ko:K00334 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - 2Fe-2S_thioredx k59_1715002_1 436308.Nmar_0620 6.31e-13 67.8 COG3356@1|root,arCOG04351@2157|Archaea,41S7S@651137|Thaumarchaeota 651137|Thaumarchaeota S Predicted membrane protein (DUF2070) - - - ko:K08979 - - - - ko00000 - - - DUF2070 k59_1715002_2 436308.Nmar_0619 1.41e-101 300.0 arCOG03727@1|root,arCOG03727@2157|Archaea,41STD@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - Mrr_cat k59_360009_1 203122.Sde_2228 2.06e-120 351.0 COG0180@1|root,COG0180@2|Bacteria,1MV4T@1224|Proteobacteria,1RNDC@1236|Gammaproteobacteria,464FH@72275|Alteromonadaceae 1236|Gammaproteobacteria J Tryptophanyl-tRNA synthetase trpS - 6.1.1.2 ko:K01867 ko00970,map00970 M00359,M00360 R03664 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_1b k59_303459_1 1122137.AQXF01000006_gene723 1.09e-26 103.0 COG2198@1|root,COG2198@2|Bacteria 2|Bacteria T Histidine kinase - - 2.7.13.3 ko:K07647 ko02020,map02020 M00455 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - Hpt k59_1206752_1 762376.AXYL_06199 3.95e-17 77.0 COG2391@1|root,COG2391@2|Bacteria,1MZ3A@1224|Proteobacteria,2VSDD@28216|Betaproteobacteria,3T4DM@506|Alcaligenaceae 28216|Betaproteobacteria S transporter component - - - ko:K07112 - - - - ko00000 - - - Sulf_transp k59_1206752_2 693986.MOC_3776 4.82e-48 159.0 COG2391@1|root,COG2391@2|Bacteria,1MZC0@1224|Proteobacteria,2U99K@28211|Alphaproteobacteria,1JV5Y@119045|Methylobacteriaceae 28211|Alphaproteobacteria S transporter component - - - ko:K07112 - - - - ko00000 - - - - k59_868658_2 1292020.H483_0112060 1.56e-46 162.0 COG0315@1|root,COG0521@1|root,COG0315@2|Bacteria,COG0521@2|Bacteria,2IHR6@201174|Actinobacteria 201174|Actinobacteria H Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP) moaC GO:0002682,GO:0002683,GO:0005575,GO:0005576,GO:0008150,GO:0009605,GO:0009607,GO:0031347,GO:0031348,GO:0035821,GO:0040007,GO:0043207,GO:0044003,GO:0044403,GO:0044413,GO:0044414,GO:0044419,GO:0045088,GO:0045824,GO:0048519,GO:0048583,GO:0048585,GO:0050776,GO:0050777,GO:0050789,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0051817,GO:0051832,GO:0051833,GO:0052031,GO:0052037,GO:0052167,GO:0052170,GO:0052173,GO:0052200,GO:0052255,GO:0052261,GO:0052306,GO:0052309,GO:0052552,GO:0052553,GO:0052561,GO:0052562,GO:0052564,GO:0052572,GO:0065007,GO:0075136,GO:0080134 4.6.1.17 ko:K03637 ko00790,ko01100,ko04122,map00790,map01100,map04122 - R11372 RC03425 ko00000,ko00001,ko01000 - - - MoCF_biosynth,MoaC k59_641488_1 396588.Tgr7_2778 1.73e-89 293.0 COG0247@1|root,COG0277@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,1MU43@1224|Proteobacteria,1RMRH@1236|Gammaproteobacteria,1WWYS@135613|Chromatiales 135613|Chromatiales C FAD linked - - - - - - - - - - - - CCG,DUF3400,DUF3683,FAD-oxidase_C,FAD_binding_4,Fer4_8 k59_1602235_1 460265.Mnod_4822 1.24e-102 305.0 COG0223@1|root,COG0223@2|Bacteria,1MW07@1224|Proteobacteria,2U0GD@28211|Alphaproteobacteria,1JSQ7@119045|Methylobacteriaceae 28211|Alphaproteobacteria H PFAM formyl transferase domain protein - - 2.1.2.9 ko:K00604 ko00670,ko00970,map00670,map00970 - R03940 RC00026,RC00165 ko00000,ko00001,ko01000 - - - Formyl_trans_C,Formyl_trans_N k59_1038355_1 446470.Snas_1369 1.66e-21 99.0 COG0544@1|root,COG0544@2|Bacteria,2GJIG@201174|Actinobacteria,4EYAP@85014|Glycomycetales 201174|Actinobacteria O Bacterial trigger factor protein (TF) C-terminus tig GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006950,GO:0007154,GO:0008150,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0016020,GO:0030312,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0042221,GO:0042594,GO:0044424,GO:0044444,GO:0044464,GO:0046677,GO:0050896,GO:0051716,GO:0071496,GO:0071944 - ko:K03545 - - - - ko00000 - - - FKBP_C,Trigger_C,Trigger_N k59_1207717_2 519989.ECTPHS_02686 1.96e-76 241.0 COG0006@1|root,COG0006@2|Bacteria,1MUZS@1224|Proteobacteria,1RN0W@1236|Gammaproteobacteria,1WWJH@135613|Chromatiales 135613|Chromatiales E peptidase M24B, X-Pro dipeptidase aminopeptidase - - 3.4.11.9 ko:K01262 - - - - ko00000,ko01000,ko01002 - - - AMP_N,Peptidase_M24 k59_1547121_1 1122137.AQXF01000003_gene2221 1.97e-76 234.0 COG1396@1|root,COG1396@2|Bacteria,1RH9T@1224|Proteobacteria,2U0E9@28211|Alphaproteobacteria 28211|Alphaproteobacteria K transcriptional regulator, XRE family - - - - - - - - - - - - Cupin_2,HTH_3 k59_1547121_2 1280698.AUJS01000031_gene1941 0.000472 42.4 COG0156@1|root,COG0156@2|Bacteria,1TPUX@1239|Firmicutes,2491D@186801|Clostridia,27WBS@189330|Dorea 186801|Clostridia H Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA kbl GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008710,GO:0008890,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016407,GO:0016408,GO:0016453,GO:0016740,GO:0016746,GO:0016747,GO:0017144,GO:0018130,GO:0019752,GO:0019842,GO:0030170,GO:0032787,GO:0034641,GO:0036094,GO:0042364,GO:0043167,GO:0043168,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0070279,GO:0071704,GO:0072330,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.3.1.29 ko:K00639 ko00260,map00260 - R00371 RC00004,RC00394 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_1_2 k59_1490857_1 1280952.HJA_06772 8.79e-56 182.0 COG0288@1|root,COG0288@2|Bacteria,1MV1U@1224|Proteobacteria,2VEYE@28211|Alphaproteobacteria,44135@69657|Hyphomonadaceae 28211|Alphaproteobacteria E Reversible hydration of carbon dioxide cynT - 4.2.1.1 ko:K01673 ko00910,map00910 - R00132,R10092 RC02807 ko00000,ko00001,ko01000 - - - Pro_CA k59_1320502_1 794903.OPIT5_21370 2.88e-91 280.0 COG3119@1|root,COG3119@2|Bacteria,46SY4@74201|Verrucomicrobia,3K8CP@414999|Opitutae 414999|Opitutae P PFAM sulfatase - - - - - - - - - - - - DUF4976,Sulfatase k59_924805_1 164757.Mjls_4784 1.61e-98 297.0 COG1804@1|root,COG1804@2|Bacteria,2GIU7@201174|Actinobacteria,233ZH@1762|Mycobacteriaceae 201174|Actinobacteria C L-carnitine dehydratase bile acid-inducible protein F - - - - - - - - - - - - CoA_transf_3 k59_1207719_1 1449049.JONW01000005_gene1131 1.2e-09 58.9 COG1595@1|root,COG1595@2|Bacteria,1Q1JT@1224|Proteobacteria,2USSW@28211|Alphaproteobacteria,2KJ1H@204458|Caulobacterales 204458|Caulobacterales K TIGRFAM RNA polymerase sigma factor, sigma-70 family - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 k59_1207719_2 1007104.SUS17_3934 7.13e-21 94.7 COG3712@1|root,COG3712@2|Bacteria,1RGU3@1224|Proteobacteria,2VFK9@28211|Alphaproteobacteria,2K5MB@204457|Sphingomonadales 204457|Sphingomonadales PT Domain of unknown function (DUF4974) - - - - - - - - - - - - DUF4880,DUF4974,FecR k59_1771873_1 1033802.SSPSH_000518 5.48e-96 293.0 COG1533@1|root,COG1533@2|Bacteria,1MW0H@1224|Proteobacteria,1RQNF@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Radical SAM - - - - - - - - - - - - Radical_SAM k59_361092_1 1122137.AQXF01000006_gene781 4.48e-129 376.0 COG0232@1|root,COG0232@2|Bacteria,1MVQ2@1224|Proteobacteria,2TRCD@28211|Alphaproteobacteria 28211|Alphaproteobacteria F Belongs to the dGTPase family. Type 2 subfamily dgt GO:0003674,GO:0003824,GO:0006139,GO:0006163,GO:0006195,GO:0006203,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008832,GO:0009056,GO:0009058,GO:0009117,GO:0009141,GO:0009143,GO:0009144,GO:0009146,GO:0009151,GO:0009155,GO:0009166,GO:0009200,GO:0009204,GO:0009215,GO:0009217,GO:0009262,GO:0009264,GO:0009394,GO:0009987,GO:0016787,GO:0016788,GO:0016793,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042578,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046070,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576 3.1.5.1 ko:K01129 ko00230,map00230 - R01856 RC00017 ko00000,ko00001,ko01000 - - - HD,HD_assoc k59_246952_1 1536772.R70723_30820 1.99e-08 55.1 COG0008@1|root,COG0008@2|Bacteria,1TP8G@1239|Firmicutes,4HBN6@91061|Bacilli,26QRZ@186822|Paenibacillaceae 91061|Bacilli J Catalyzes a two-step reaction, first charging a glutamine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA glnS - 6.1.1.18 ko:K01886 ko00970,ko01100,map00970,map01100 M00359,M00360 R03652 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_1c,tRNA-synt_1c_C k59_246952_2 1122201.AUAZ01000008_gene450 1.25e-35 125.0 COG0652@1|root,COG0652@2|Bacteria,1R9ZQ@1224|Proteobacteria,1S222@1236|Gammaproteobacteria,466DM@72275|Alteromonadaceae 1236|Gammaproteobacteria O PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides ppiB GO:0000413,GO:0003674,GO:0003755,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016853,GO:0016859,GO:0018193,GO:0018208,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0140096,GO:1901564 5.2.1.8 ko:K03768 - - - - ko00000,ko01000,ko03110 - - - Pro_isomerase k59_1263241_2 1385935.N836_24755 4.76e-89 263.0 COG3558@1|root,COG3558@2|Bacteria,1G54U@1117|Cyanobacteria,1HANA@1150|Oscillatoriales 1117|Cyanobacteria S Protein of unknown function (DUF1348) - - - ko:K09958 - - - - ko00000 - - - DUF1348 k59_1263241_3 1122603.ATVI01000005_gene3040 3.64e-95 296.0 COG2239@1|root,COG2239@2|Bacteria,1MW24@1224|Proteobacteria,1RNE4@1236|Gammaproteobacteria,1X4NW@135614|Xanthomonadales 1236|Gammaproteobacteria P Acts as a magnesium transporter mgtE - - ko:K06213 - - - - ko00000,ko02000 1.A.26.1 - - CBS,MgtE,MgtE_N k59_1490871_1 1131266.ARWQ01000001_gene1346 1.1e-11 70.1 arCOG08812@1|root,arCOG08812@2157|Archaea,41T0K@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_869676_1 261292.Nit79A3_0176 2.92e-13 68.2 COG0120@1|root,COG0120@2|Bacteria,1MVGR@1224|Proteobacteria,2VH27@28216|Betaproteobacteria,371V1@32003|Nitrosomonadales 28216|Betaproteobacteria G Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate rpiA - 5.3.1.6 ko:K01807 ko00030,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167,M00580 R01056 RC00434 ko00000,ko00001,ko00002,ko01000 - - - Rib_5-P_isom_A,Sugar-bind k59_869676_2 506534.Rhein_3760 3.71e-60 194.0 COG0179@1|root,COG0179@2|Bacteria,1MVFA@1224|Proteobacteria,1RN6Y@1236|Gammaproteobacteria,1X10P@135613|Chromatiales 135613|Chromatiales Q Fumarylacetoacetate (FAA) hydrolase family - - 3.7.1.20 ko:K16165 ko00350,ko01100,ko01120,map00350,map01100,map01120 - R01085 RC00326,RC00446 ko00000,ko00001,ko01000 - - - FAA_hydrolase k59_134436_1 445696.E3SSZ9_9CAUD 9.96e-11 67.0 4QB5I@10239|Viruses,4QUT2@35237|dsDNA viruses no RNA stage,4QPQ9@28883|Caudovirales,4QII1@10662|Myoviridae 10662|Myoviridae S N-methyltransferase activity - - - - - - - - - - - - - k59_21544_1 1454004.AW11_02987 1.38e-35 126.0 COG0521@1|root,COG0521@2|Bacteria,1R9W2@1224|Proteobacteria,2VH28@28216|Betaproteobacteria,1KQN4@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria H Probable molybdopterin binding domain mogA - 2.7.7.75 ko:K03831 ko00790,ko01100,ko04122,map00790,map01100,map04122 - R09726 RC00002 ko00000,ko00001,ko01000 - - - MoCF_biosynth k59_21544_2 1172188.KB911821_gene1278 3.87e-44 150.0 COG0207@1|root,COG0207@2|Bacteria,2GKY0@201174|Actinobacteria,4FFQE@85021|Intrasporangiaceae 201174|Actinobacteria F Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis thyA GO:0003674,GO:0003824,GO:0004799,GO:0006139,GO:0006220,GO:0006221,GO:0006231,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0009056,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009125,GO:0009129,GO:0009130,GO:0009131,GO:0009157,GO:0009159,GO:0009162,GO:0009165,GO:0009166,GO:0009176,GO:0009177,GO:0009178,GO:0009219,GO:0009221,GO:0009223,GO:0009262,GO:0009263,GO:0009264,GO:0009265,GO:0009394,GO:0009987,GO:0016740,GO:0016741,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0032259,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042083,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046073,GO:0046078,GO:0046079,GO:0046385,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0072529,GO:0090407,GO:1901135,GO:1901136,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576 2.1.1.45 ko:K00560 ko00240,ko00670,ko01100,ko01523,map00240,map00670,map01100,map01523 M00053 R02101 RC00219,RC00332 ko00000,ko00001,ko00002,ko01000 - - - Thymidylat_synt k59_1659913_1 1040989.AWZU01000035_gene1775 6.55e-114 336.0 COG4948@1|root,COG4948@2|Bacteria,1MURK@1224|Proteobacteria,2U10C@28211|Alphaproteobacteria,3JR02@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria M Mandelate racemase / muconate lactonizing enzyme, N-terminal domain - - - - - - - - - - - - MR_MLE_C,MR_MLE_N k59_586077_1 1110502.TMO_0647 6.9e-12 68.6 COG1309@1|root,COG1309@2|Bacteria,1RDIM@1224|Proteobacteria,2VEVK@28211|Alphaproteobacteria,2JYN8@204441|Rhodospirillales 204441|Rhodospirillales K Bacterial regulatory proteins, tetR family - - - - - - - - - - - - TetR_N k59_586077_2 243365.CV_2723 8.69e-05 45.1 COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,2VKIW@28216|Betaproteobacteria,2KQAT@206351|Neisseriales 206351|Neisseriales I Domain of unknown function (DUF1974) - - - ko:K06445 ko00071,ko01100,ko01212,map00071,map01100,map01212 M00087 R01175,R01279,R03777,R03857,R03990,R04751,R04754 RC00052,RC00076 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N,DUF1974 k59_1727251_1 1121861.KB899935_gene456 9.53e-111 327.0 COG2025@1|root,COG2025@2|Bacteria,1MUFI@1224|Proteobacteria,2TR10@28211|Alphaproteobacteria,2JPTQ@204441|Rhodospirillales 204441|Rhodospirillales C electron transfer flavoprotein, alpha subunit etfA - - ko:K03522 - - - - ko00000,ko04147 - - - ETF,ETF_alpha k59_536715_1 1472716.KBK24_0120090 5.03e-58 193.0 COG4638@1|root,COG4638@2|Bacteria,1MWXW@1224|Proteobacteria,2VM92@28216|Betaproteobacteria,1K3SA@119060|Burkholderiaceae 28216|Betaproteobacteria P dioxygenase alpha subunit - - - - - - - - - - - - Rieske,Ring_hydroxyl_A k59_651475_1 1088868.CIN_11080 1.4e-164 475.0 COG0459@1|root,COG0459@2|Bacteria,1MURR@1224|Proteobacteria,2TS07@28211|Alphaproteobacteria,2JPIQ@204441|Rhodospirillales 204441|Rhodospirillales O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions groL - - ko:K04077 ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 - - - Cpn60_TCP1 k59_90527_1 936455.KI421499_gene6944 5.75e-36 142.0 COG2304@1|root,COG2304@2|Bacteria,1MW8K@1224|Proteobacteria,2TV9Y@28211|Alphaproteobacteria,3JSX0@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S Vault protein inter-alpha-trypsin domain - - - ko:K07114 - - - - ko00000,ko02000 1.A.13.2.2,1.A.13.2.3 - - VIT,VWA_3 k59_598702_1 316407.85676414 7.75e-130 375.0 COG0438@1|root,COG0438@2|Bacteria,1PDRU@1224|Proteobacteria,1S0YU@1236|Gammaproteobacteria,3XQF3@561|Escherichia 1236|Gammaproteobacteria M Adds a galactose goup to a glucose group of LPS rfaB GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008194,GO:0008378,GO:0008610,GO:0008653,GO:0008921,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033692,GO:0034637,GO:0034645,GO:0035250,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0046401,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 - ko:K02840 ko00540,ko01100,map00540,map01100 M00080 - - ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT4 - Glyco_transf_4,Glycos_transf_1 k59_882278_1 1122137.AQXF01000001_gene3034 5.28e-75 226.0 COG0735@1|root,COG0735@2|Bacteria,1RDWJ@1224|Proteobacteria,2U6ZS@28211|Alphaproteobacteria 28211|Alphaproteobacteria K Belongs to the Fur family fur - - ko:K03711 - - - - ko00000,ko03000 - - - FUR k59_1442198_1 1397699.JNIS01000001_gene1899 0.000342 46.2 COG3258@1|root,COG3258@2|Bacteria,1TSHS@1239|Firmicutes,4HBXB@91061|Bacilli,3WFGK@539002|Bacillales incertae sedis 91061|Bacilli C Cytochrome c - - 1.8.2.2 ko:K19713 - - - - ko00000,ko01000 - - - Cytochrom_C,Cytochrome_CBB3 k59_1727255_1 436308.Nmar_0058 2.58e-129 370.0 COG2243@1|root,arCOG00648@2157|Archaea,41SGJ@651137|Thaumarchaeota 651137|Thaumarchaeota H Tetrapyrrole (Corrin/Porphyrin) Methylases - - 2.1.1.130,2.1.1.151 ko:K03394 ko00860,ko01100,map00860,map01100 - R03948,R05808 RC00003,RC01035,RC01662 ko00000,ko00001,ko01000 - - - TP_methylase k59_259209_1 1232410.KI421425_gene1565 5.46e-130 396.0 COG0437@1|root,COG0437@2|Bacteria,1MU1B@1224|Proteobacteria,42NEG@68525|delta/epsilon subdivisions,2WKHA@28221|Deltaproteobacteria,43TY6@69541|Desulfuromonadales 28221|Deltaproteobacteria C 4Fe-4S dicluster domain actB - - ko:K00184 - - - - ko00000 5.A.3 - - Fer4_7,Molybdop_Fe4S4,Molybdopterin,Molydop_binding k59_536719_1 382464.ABSI01000006_gene795 7.01e-23 100.0 COG3211@1|root,COG3211@2|Bacteria 2|Bacteria O Phosphatase phoX - - ko:K07093 - - - - ko00000 - - - DUF839,Metallophos,Pur_ac_phosph_N k59_426039_1 744979.R2A130_0237 5.1e-15 71.2 COG2127@1|root,COG2127@2|Bacteria,1MZU8@1224|Proteobacteria,2U982@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation clpS - - ko:K06891 - - - - ko00000 - - - ClpS k59_426039_2 1121921.KB898707_gene1179 5.72e-20 80.9 COG1278@1|root,COG1278@2|Bacteria,1N6Q5@1224|Proteobacteria,1SCA7@1236|Gammaproteobacteria,2PNX7@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria K Cold shock protein domain cspD GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006275,GO:0006355,GO:0006950,GO:0008150,GO:0008156,GO:0009266,GO:0009409,GO:0009605,GO:0009628,GO:0009889,GO:0009890,GO:0009892,GO:0009991,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031667,GO:0042594,GO:0044424,GO:0044444,GO:0044464,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051053,GO:0051171,GO:0051172,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2000112,GO:2000113,GO:2001141 - ko:K03704 - - - - ko00000,ko03000 - - - CSD k59_711844_1 1229909.NSED_01190 2.68e-108 327.0 COG1053@1|root,arCOG00571@2157|Archaea,41SAM@651137|Thaumarchaeota 651137|Thaumarchaeota C fumarate reductase flavoprotein - - 1.3.5.1,1.3.5.4 ko:K00239 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134 M00009,M00011,M00149,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,Succ_DH_flav_C k59_1103753_1 1094466.KQS_08075 6.41e-13 74.3 COG5184@1|root,COG5184@2|Bacteria,4NIF9@976|Bacteroidetes,1HZZU@117743|Flavobacteriia,2NUST@237|Flavobacterium 976|Bacteroidetes DZ Regulator of chromosome condensation (RCC1) repeat - - - - - - - - - - - - DUF4988,RCC1,RCC1_2 k59_259218_1 639030.JHVA01000001_gene788 2.19e-61 208.0 COG1472@1|root,COG1472@2|Bacteria,3Y482@57723|Acidobacteria,2JINY@204432|Acidobacteriia 204432|Acidobacteriia G Fibronectin type III-like domain - - 3.2.1.21 ko:K05349 ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110 - R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040 RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248 ko00000,ko00001,ko01000 - GH3 - Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C k59_481566_1 448385.sce9161 1.92e-48 176.0 COG0515@1|root,COG3899@1|root,COG0515@2|Bacteria,COG3899@2|Bacteria,1Q4QW@1224|Proteobacteria,4388X@68525|delta/epsilon subdivisions,2X3II@28221|Deltaproteobacteria,2YW8D@29|Myxococcales 28221|Deltaproteobacteria KLT AAA ATPase domain - - - - - - - - - - - - AAA_16,Pkinase k59_1779682_1 1385517.N800_12250 7.27e-18 91.7 COG1228@1|root,COG1228@2|Bacteria,1MY4V@1224|Proteobacteria,1RZRK@1236|Gammaproteobacteria,1X4X1@135614|Xanthomonadales 135614|Xanthomonadales Q Amidohydrolase family - - - - - - - - - - - - Amidohydro_1 k59_317326_1 1396858.Q666_12885 2.12e-69 219.0 COG4535@1|root,COG4535@2|Bacteria,1QTU8@1224|Proteobacteria,1RMKX@1236|Gammaproteobacteria,4658M@72275|Alteromonadaceae 1236|Gammaproteobacteria P Mg2 and Co2 transporter CorC corC GO:0001897,GO:0001906,GO:0001907,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0009405,GO:0009987,GO:0016020,GO:0019835,GO:0019836,GO:0031640,GO:0035821,GO:0044003,GO:0044004,GO:0044179,GO:0044364,GO:0044403,GO:0044419,GO:0044464,GO:0044764,GO:0051701,GO:0051704,GO:0051715,GO:0051801,GO:0051817,GO:0051818,GO:0051883,GO:0052331,GO:0071944 - ko:K06189 - - - - ko00000,ko02000 9.A.40.1.2 - - CBS,CorC_HlyC k59_1103757_1 1219035.NT2_02_01590 3.48e-83 262.0 COG1384@1|root,COG1384@2|Bacteria,1MV32@1224|Proteobacteria,2TQYH@28211|Alphaproteobacteria,2K1S0@204457|Sphingomonadales 204457|Sphingomonadales J Belongs to the class-I aminoacyl-tRNA synthetase family lysS - 6.1.1.6 ko:K04566 ko00970,map00970 M00360 R03658 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_1f k59_1669444_1 272568.GDI0086 2.17e-57 195.0 2CDQ7@1|root,2Z7KV@2|Bacteria,1MY2D@1224|Proteobacteria,2TR92@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_481575_1 180332.JTGN01000018_gene27 1.75e-16 84.7 COG5520@1|root,COG5520@2|Bacteria,1TS99@1239|Firmicutes,249YD@186801|Clostridia 186801|Clostridia G Belongs to the glycosyl hydrolase 30 family - - 3.2.1.45 ko:K01201 ko00511,ko00600,ko01100,ko04142,map00511,map00600,map01100,map04142 - R01498 RC00059,RC00451 ko00000,ko00001,ko01000 - GH30 - Glyco_hydro_30,Glyco_hydro_30C k59_1727276_1 1121935.AQXX01000126_gene908 2.81e-12 67.4 COG0631@1|root,COG0631@2|Bacteria,1R7UF@1224|Proteobacteria,1S4U5@1236|Gammaproteobacteria,1XJZ6@135619|Oceanospirillales 135619|Oceanospirillales T serine threonine protein phosphatase - - 3.1.3.16 ko:K01090 - - - - ko00000,ko01000 - - - PP2C_2 k59_821919_1 87626.PTD2_00527 1.65e-09 64.3 COG1521@1|root,COG1521@2|Bacteria,1MUYA@1224|Proteobacteria,1S99V@1236|Gammaproteobacteria,2Q1IB@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria F Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis coaX - 2.7.1.33 ko:K03525 ko00770,ko01100,map00770,map01100 M00120 R02971,R03018,R04391 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - Pan_kinase k59_144964_1 1173024.KI912153_gene5 5.48e-12 72.4 COG2850@1|root,COG2850@2|Bacteria,1G3C8@1117|Cyanobacteria 1117|Cyanobacteria O PFAM Cupin superfamily protein - - 1.14.11.27,1.14.11.30 ko:K10277,ko:K18055 - - - - ko00000,ko01000,ko03036 - - - Cupin_8 k59_1272551_1 1122194.AUHU01000003_gene2380 4.12e-31 123.0 COG0784@1|root,COG0784@2|Bacteria,1N1YE@1224|Proteobacteria,1S9PD@1236|Gammaproteobacteria,468H1@72275|Alteromonadaceae 1236|Gammaproteobacteria T COG0784 FOG CheY-like receiver - - - - - - - - - - - - Response_reg k59_598746_1 247634.GPB2148_1375 3.95e-113 333.0 COG0057@1|root,COG0057@2|Bacteria,1MU93@1224|Proteobacteria,1RMBM@1236|Gammaproteobacteria,1J4IE@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Belongs to the glyceraldehyde-3-phosphate dehydrogenase family gapA GO:0000166,GO:0003674,GO:0003824,GO:0004365,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016052,GO:0016053,GO:0016310,GO:0016491,GO:0016620,GO:0016903,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0036094,GO:0042866,GO:0043436,GO:0043891,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0051287,GO:0055086,GO:0055114,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:1901135,GO:1901137,GO:1901265,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901575,GO:1901576 1.2.1.12 ko:K00134 ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01061 RC00149 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - iAPECO1_1312.APECO1_847,iPC815.YPO2157,iUTI89_1310.UTI89_C1975,ic_1306.c2184 Gp_dh_C,Gp_dh_N k59_481582_1 391615.ABSJ01000005_gene574 1.53e-70 224.0 COG3608@1|root,COG3608@2|Bacteria,1MUAA@1224|Proteobacteria,1RNQQ@1236|Gammaproteobacteria,1J4NN@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Succinylglutamate desuccinylase aspartoacylase - - - ko:K06987 - - - - ko00000 - - - AstE_AspA k59_144965_1 317013.NY99_03475 3.29e-60 200.0 COG1560@1|root,COG1560@2|Bacteria,1MVNI@1224|Proteobacteria,1RMZ5@1236|Gammaproteobacteria,1X3W9@135614|Xanthomonadales 135614|Xanthomonadales M Catalyzes the transfer of laurate from lauroyl-acyl carrier protein (ACP) to Kdo(2)-lipid IV(A) to form Kdo(2)- (lauroyl)-lipid IV(A) lpxL - 2.3.1.241 ko:K02517 ko00540,ko01100,map00540,map01100 M00060 R05146 RC00037,RC00039 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Lip_A_acyltrans k59_259253_1 641526.ADIWIN_1698 1.02e-37 139.0 COG1360@1|root,COG1360@2|Bacteria,4NGHP@976|Bacteroidetes,1HXG8@117743|Flavobacteriia 976|Bacteroidetes N Cell envelope biogenesis protein OmpA - - - ko:K02557 ko02030,ko02040,map02030,map02040 - - - ko00000,ko00001,ko02000,ko02035 1.A.30.1 - - OmpA k59_201587_1 1151127.KB906326_gene382 3.62e-06 50.1 COG1028@1|root,COG1028@2|Bacteria,1MW9A@1224|Proteobacteria,1RMC9@1236|Gammaproteobacteria,1YQIR@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria IQ short chain dehydrogenase reductase family - - - - - - - - - - - - adh_short_C2 k59_598758_1 349124.Hhal_1870 7.55e-79 245.0 COG1180@1|root,COG1180@2|Bacteria,1NQC1@1224|Proteobacteria,1T0C6@1236|Gammaproteobacteria,1WXH4@135613|Chromatiales 135613|Chromatiales C PFAM Radical SAM - - 1.97.1.4 ko:K04069 - - R04710 - ko00000,ko01000 - - - Fer4_12,Radical_SAM k59_598758_2 1150469.RSPPHO_02915 8.64e-11 62.8 COG1355@1|root,COG1355@2|Bacteria,1MXK5@1224|Proteobacteria,2U13I@28211|Alphaproteobacteria,2JQVM@204441|Rhodospirillales 204441|Rhodospirillales S Belongs to the MEMO1 family - - - ko:K06990 - - - - ko00000,ko04812 - - - AMMECR1,Memo k59_1779702_1 1229909.NSED_01615 4.79e-309 846.0 COG1032@1|root,arCOG01357@2157|Archaea,41S86@651137|Thaumarchaeota 651137|Thaumarchaeota C Radical SAM - - - - - - - - - - - - Radical_SAM k59_1219299_2 1144275.COCOR_03988 1.34e-23 103.0 COG4774@1|root,COG4774@2|Bacteria,1MV0X@1224|Proteobacteria 1224|Proteobacteria P TonB-dependent siderophore receptor bfrD - - ko:K16090 - - - - ko00000,ko02000 1.B.14.1.11 - - Plug,TonB_dep_Rec k59_1442238_1 1123234.AUKI01000017_gene2681 9.95e-162 468.0 COG2721@1|root,COG2721@2|Bacteria,4NFVQ@976|Bacteroidetes,1HXWR@117743|Flavobacteriia 976|Bacteroidetes G Altronate hydrolase uxaA - 4.2.1.7 ko:K01685 ko00040,ko01100,map00040,map01100 M00631 R01540 RC00543 ko00000,ko00001,ko00002,ko01000 - - - GD_AH_C,SAF k59_598759_1 1122137.AQXF01000007_gene3481 9.67e-40 137.0 COG1011@1|root,COG1011@2|Bacteria,1RHAB@1224|Proteobacteria,2U7PV@28211|Alphaproteobacteria 28211|Alphaproteobacteria S hydrolase (HAD superfamily) - - 3.8.1.2 ko:K01560,ko:K07025 ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120 - R05287 RC00697 ko00000,ko00001,ko01000 - - - HAD_2 k59_823202_1 391603.FBALC1_13157 4.09e-54 192.0 28JMC@1|root,2Z9DW@2|Bacteria,4NIFI@976|Bacteroidetes,1HXDM@117743|Flavobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_1443179_1 247634.GPB2148_52 9.66e-57 185.0 COG1082@1|root,COG1082@2|Bacteria,1MVSJ@1224|Proteobacteria,1RRKK@1236|Gammaproteobacteria,1J5MG@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L AP endonuclease family 2 C terminus - - - - - - - - - - - - AP_endonuc_2,AP_endonuc_2_N k59_1443179_2 1502850.FG91_01882 4.88e-43 155.0 COG3828@1|root,COG3828@2|Bacteria,1R5XA@1224|Proteobacteria,2U51F@28211|Alphaproteobacteria,2KDTS@204457|Sphingomonadales 204457|Sphingomonadales S Trehalose utilisation - - - ko:K09992 - - - - ko00000 - - - ThuA k59_764821_1 1323663.AROI01000035_gene1335 5e-78 246.0 COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,1RNGU@1236|Gammaproteobacteria 1236|Gammaproteobacteria I Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed pcaF - 2.3.1.16,2.3.1.9 ko:K00626,ko:K00632 ko00071,ko00072,ko00280,ko00281,ko00310,ko00362,ko00380,ko00592,ko00620,ko00630,ko00640,ko00642,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00281,map00310,map00362,map00380,map00592,map00620,map00630,map00640,map00642,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00087,M00088,M00095,M00113,M00373,M00374,M00375 R00238,R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095 RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N k59_318672_1 1122137.AQXF01000001_gene3133 3.59e-108 318.0 COG0568@1|root,COG0568@2|Bacteria,1MUXA@1224|Proteobacteria,2TUED@28211|Alphaproteobacteria 28211|Alphaproteobacteria K RNA polymerase sigma rpoH2 - - ko:K03089 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4 k59_883595_1 1229909.NSED_09625 1.05e-57 186.0 arCOG08041@1|root,arCOG08041@2157|Archaea,41SRT@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - HTH_27 k59_600054_1 1499685.CCFJ01000042_gene2487 2.37e-25 107.0 COG3677@1|root,COG3677@2|Bacteria,1UYY4@1239|Firmicutes,4HDGD@91061|Bacilli,1ZD8V@1386|Bacillus 91061|Bacilli L ISXO2-like transposase domain - - - - - - - - - - - - DDE_Tnp_IS1595 k59_35569_1 246197.MXAN_6186 2.84e-102 313.0 COG1760@1|root,COG1760@2|Bacteria,1MUZN@1224|Proteobacteria,42N88@68525|delta/epsilon subdivisions,2WISX@28221|Deltaproteobacteria,2YU3P@29|Myxococcales 28221|Deltaproteobacteria E Serine dehydratase beta chain sdaA - 4.3.1.17 ko:K01752 ko00260,ko00270,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00270,map01100,map01110,map01130,map01200,map01230 - R00220,R00590 RC00331,RC02600 ko00000,ko00001,ko01000 - - - SDH_alpha,SDH_beta k59_600055_1 1114964.L485_16570 6.94e-101 314.0 COG1629@1|root,COG4771@2|Bacteria,1MVFB@1224|Proteobacteria,2U0N7@28211|Alphaproteobacteria,2KEFU@204457|Sphingomonadales 204457|Sphingomonadales P TonB-dependent receptor plug - - - - - - - - - - - - Plug,TonB_dep_Rec k59_375236_1 1121861.KB899910_gene852 5.26e-18 79.7 COG3193@1|root,COG3193@2|Bacteria,1N08N@1224|Proteobacteria,2U5ES@28211|Alphaproteobacteria 28211|Alphaproteobacteria S protein possibly involved in utilization of glycolate and propanediol - - - - - - - - - - - - Haem_degrading k59_202830_1 1298867.AUES01000051_gene4511 7.12e-16 83.6 COG0771@1|root,COG2931@1|root,COG4625@1|root,COG0771@2|Bacteria,COG2931@2|Bacteria,COG4625@2|Bacteria,1MU7T@1224|Proteobacteria,2TRVY@28211|Alphaproteobacteria,3K2H3@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria Q Haemolysin-type calcium-binding repeat (2 copies) - - - - - - - - - - - - FG-GAP,HemolysinCabind k59_1330264_1 926560.KE387023_gene1698 7.07e-69 226.0 COG0492@1|root,COG3437@1|root,COG0492@2|Bacteria,COG3437@2|Bacteria,1WM1W@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus KOT FAD dependent oxidoreductase - - - - - - - - - - - - Pyr_redox_2,Response_reg k59_823238_1 1121935.AQXX01000109_gene480 1.82e-71 240.0 COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,1SP6I@1236|Gammaproteobacteria,1XHSN@135619|Oceanospirillales 135619|Oceanospirillales P Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K07787 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.6.1.4 - - ACR_tran k59_318698_1 8090.ENSORLP00000004959 1.99e-33 133.0 2AIEU@1|root,2RZ4M@2759|Eukaryota,39NWY@33154|Opisthokonta,3CQF8@33208|Metazoa,3E6MD@33213|Bilateria 33208|Metazoa S Transposase - - - - - - - - - - - - DDE_3,HTH_Tnp_Tc3_2 k59_537594_1 1442599.JAAN01000035_gene624 1.31e-64 212.0 COG0065@1|root,COG0065@2|Bacteria,1MVYR@1224|Proteobacteria,1RMF6@1236|Gammaproteobacteria,1X3KZ@135614|Xanthomonadales 135614|Xanthomonadales E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate leuC - 4.2.1.33,4.2.1.35 ko:K01703 ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230 M00432,M00535 R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170 RC00497,RC00976,RC00977,RC01041,RC01046,RC03072 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase k59_1615618_1 867845.KI911784_gene2230 4.58e-25 109.0 COG2203@1|root,COG3437@1|root,COG3852@1|root,COG2203@2|Bacteria,COG3437@2|Bacteria,COG3852@2|Bacteria,2GBQK@200795|Chloroflexi,3776Y@32061|Chloroflexia 32061|Chloroflexia T SMART PAS domain containing protein - - - - - - - - - - - - GAF_2,HATPase_c,PAS_4,Response_reg k59_91541_1 1144305.PMI02_02558 1.03e-62 195.0 COG0748@1|root,COG0748@2|Bacteria,1N3E8@1224|Proteobacteria,2UPF5@28211|Alphaproteobacteria,2K8HZ@204457|Sphingomonadales 204457|Sphingomonadales P Pfam:DUF385 - - - - - - - - - - - - F420H2_quin_red k59_91541_2 28444.JODQ01000010_gene3183 1.13e-39 140.0 KOG2391@1|root,3279X@2|Bacteria,2I3V8@201174|Actinobacteria,4ER48@85012|Streptosporangiales 201174|Actinobacteria O protein transport - - - - - - - - - - - - - k59_990448_1 580332.Slit_2644 4.85e-32 129.0 COG4262@1|root,COG4262@2|Bacteria,1RFPU@1224|Proteobacteria,2VQJ5@28216|Betaproteobacteria 28216|Betaproteobacteria E Spermidine synthase - - 2.5.1.16 ko:K00797 ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100 M00034,M00133 R01920,R02869,R08359 RC00021,RC00053 ko00000,ko00001,ko00002,ko01000 - - - Spermine_synth k59_1728229_2 760192.Halhy_2437 5.15e-21 89.0 COG2010@1|root,COG2010@2|Bacteria,4NSE3@976|Bacteroidetes,1IT2V@117747|Sphingobacteriia 976|Bacteroidetes C Haem-binding domain - - - - - - - - - - - - Haem_bd k59_1391879_1 1532557.JL37_15410 1.2e-92 281.0 COG1173@1|root,COG1173@2|Bacteria,1MUG0@1224|Proteobacteria,2VIN2@28216|Betaproteobacteria,3T5VQ@506|Alcaligenaceae 28216|Betaproteobacteria P ABC-type dipeptide oligopeptide nickel transport systems, permease components dppC_1 - - ko:K02034 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1,OppC_N k59_1163514_1 1207063.P24_13673 6.58e-114 341.0 COG1053@1|root,COG1053@2|Bacteria,1MX5A@1224|Proteobacteria,2TV7T@28211|Alphaproteobacteria,2JQSB@204441|Rhodospirillales 204441|Rhodospirillales C FAD dependent oxidoreductase - - - - - - - - - - - - FAD_binding_2 k59_1163514_2 631454.N177_0648 3.85e-84 265.0 COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,2TSTW@28211|Alphaproteobacteria 28211|Alphaproteobacteria EH Belongs to the TPP enzyme family ilvB - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_1052160_1 1231391.AMZF01000018_gene1831 5.44e-51 172.0 COG2159@1|root,COG2159@2|Bacteria,1R5PG@1224|Proteobacteria,2VPKM@28216|Betaproteobacteria,3T38J@506|Alcaligenaceae 28216|Betaproteobacteria S Amidohydrolase - - 4.1.1.45 ko:K03392 ko00380,ko01100,map00380,map01100 M00038 R04323 RC00779 ko00000,ko00001,ko00002,ko01000 - - - Amidohydro_2 k59_1052160_2 504728.K649_09785 2.12e-50 169.0 COG0179@1|root,COG0179@2|Bacteria,1WJ13@1297|Deinococcus-Thermus 2|Bacteria Q COGs COG0179 2-keto-4-pentenoate hydratase 2-oxohepta-3-ene-1 7-dioic acid hydratase (catechol pathway) - - - - - - - - - - - - FAA_hydrolase k59_375272_1 311402.Avi_0886 8.09e-36 133.0 COG0582@1|root,COG0582@2|Bacteria,1R7GV@1224|Proteobacteria,2TT06@28211|Alphaproteobacteria,4BFR6@82115|Rhizobiaceae 28211|Alphaproteobacteria L Belongs to the 'phage' integrase family intD - - - - - - - - - - - Phage_integrase k59_990455_1 1415778.JQMM01000001_gene808 1.24e-23 92.0 2A0V3@1|root,30P03@2|Bacteria,1QAYJ@1224|Proteobacteria,1RTSS@1236|Gammaproteobacteria,1JBCP@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_990455_2 870187.Thini_2015 8.11e-27 110.0 COG0793@1|root,COG0793@2|Bacteria,1MU39@1224|Proteobacteria,1RMSR@1236|Gammaproteobacteria,45ZP3@72273|Thiotrichales 72273|Thiotrichales M Belongs to the peptidase S41A family - - 3.4.21.102 ko:K03797 - - - - ko00000,ko01000,ko01002 - - - PDZ_2,Peptidase_S41 k59_1330288_1 981336.F944_02500 1.65e-124 367.0 COG0493@1|root,COG0493@2|Bacteria,1MU2H@1224|Proteobacteria,1RMY7@1236|Gammaproteobacteria,3NIS3@468|Moraxellaceae 1236|Gammaproteobacteria E glutamate synthase gltD GO:0003674,GO:0003824,GO:0004355,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0015930,GO:0016053,GO:0016491,GO:0016638,GO:0016639,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045181,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.4.1.13,1.4.1.14 ko:K00266 ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 - R00093,R00114,R00248 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - iEC042_1314.EC042_3503,iYL1228.KPN_03625 Fer4_11,Fer4_20,Pyr_redox_2 k59_1780545_1 366602.Caul_3288 4.12e-59 202.0 COG1472@1|root,COG1472@2|Bacteria,1MVIV@1224|Proteobacteria,2TS28@28211|Alphaproteobacteria,2KHXB@204458|Caulobacterales 204458|Caulobacterales G PFAM glycoside hydrolase family 3 domain protein - - 3.2.1.21 ko:K05349 ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110 - R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040 RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248 ko00000,ko00001,ko01000 - GH3 - Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C k59_883661_2 1415780.JPOG01000001_gene2435 5.61e-21 92.0 COG2836@1|root,COG2836@2|Bacteria,1RIGJ@1224|Proteobacteria,1S5V1@1236|Gammaproteobacteria,1X66I@135614|Xanthomonadales 135614|Xanthomonadales S Cytochrome C biogenesis protein transmembrane region - - - ko:K09792 - - - - ko00000 - - - DsbD_2 k59_260569_1 1265502.KB905931_gene1626 4.43e-13 69.7 COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,2VHAN@28216|Betaproteobacteria,4AARD@80864|Comamonadaceae 28216|Betaproteobacteria V ABC transporter, transmembrane region - - - ko:K06147 - - - - ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran k59_1273412_1 177437.HRM2_41770 1.35e-17 87.4 COG0609@1|root,COG0609@2|Bacteria,1MV9W@1224|Proteobacteria,42PIH@68525|delta/epsilon subdivisions,2WJH2@28221|Deltaproteobacteria,2MIKZ@213118|Desulfobacterales 28221|Deltaproteobacteria P Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily - - - ko:K02015 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko02000 3.A.1.14 - - FecCD k59_1273412_2 869210.Marky_2000 1.53e-27 116.0 COG0614@1|root,COG0614@2|Bacteria,1WIQT@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus P ABC-type Fe3 -hydroxamate transport system, periplasmic component - - - ko:K02016 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko02000 3.A.1.14 - - Peripla_BP_2 k59_1562220_1 1232683.ADIMK_4139 4.07e-144 438.0 COG1305@1|root,COG4196@1|root,COG1305@2|Bacteria,COG4196@2|Bacteria,1MVAG@1224|Proteobacteria,1RMX2@1236|Gammaproteobacteria,464EZ@72275|Alteromonadaceae 1236|Gammaproteobacteria E Putative amidoligase enzyme (DUF2126) IV02_11925 - - - - - - - - - - - Bact_transglu_N,DUF2126,Transglut_core k59_652524_2 1229909.NSED_04885 1.24e-26 99.0 arCOG11517@1|root,arCOG11517@2157|Archaea,41TAE@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1562225_1 1123355.JHYO01000002_gene1263 3.01e-33 122.0 COG1773@1|root,COG1773@2|Bacteria,1MV2U@1224|Proteobacteria,2TV0P@28211|Alphaproteobacteria,36XXV@31993|Methylocystaceae 28211|Alphaproteobacteria C HupH hydrogenase expression protein, C-terminal conserved region hupH - - ko:K03618 - - - - ko00000 - - - HupH_C k59_1562225_2 670307.HYPDE_28318 5.28e-35 120.0 COG1773@1|root,COG1773@2|Bacteria,1N6TQ@1224|Proteobacteria 1224|Proteobacteria C Belongs to the rubredoxin family hupI - - - - - - - - - - - Rubredoxin k59_823306_1 395494.Galf_1381 3.43e-85 277.0 COG0045@1|root,COG0454@1|root,COG1042@1|root,COG0045@2|Bacteria,COG0456@2|Bacteria,COG1042@2|Bacteria,1MW98@1224|Proteobacteria,2VI9R@28216|Betaproteobacteria,44WDS@713636|Nitrosomonadales 28216|Betaproteobacteria C PFAM CoA-binding domain protein yfiQ - - ko:K09181 - - - - ko00000 - - - ATP-grasp_5,Acetyltransf_1,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig k59_600144_1 1122137.AQXF01000002_gene36 8.68e-08 52.4 COG1117@1|root,COG1117@2|Bacteria,1MU16@1224|Proteobacteria,2TQX9@28211|Alphaproteobacteria 28211|Alphaproteobacteria P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system pstB - 3.6.3.27 ko:K02036 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.7 - - ABC_tran k59_600144_2 1122137.AQXF01000002_gene37 8.12e-134 390.0 COG0581@1|root,COG0581@2|Bacteria,1MUWB@1224|Proteobacteria,2TQYQ@28211|Alphaproteobacteria 28211|Alphaproteobacteria P phosphate transport system permease pstA - - ko:K02038 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - BPD_transp_1,DUF3333 k59_1512624_2 1211114.ALIP01000060_gene792 1.64e-44 145.0 COG2963@1|root,COG2963@2|Bacteria,1MZ3D@1224|Proteobacteria,1S9EI@1236|Gammaproteobacteria,1X74K@135614|Xanthomonadales 135614|Xanthomonadales L Transposase - - - ko:K07497 - - - - ko00000 - - - HTH_Tnp_1 k59_1112320_1 1288826.MSNKSG1_14177 2.87e-60 197.0 COG0598@1|root,COG0598@2|Bacteria,1MW8W@1224|Proteobacteria,1RRTZ@1236|Gammaproteobacteria,464S0@72275|Alteromonadaceae 1236|Gammaproteobacteria P CorA-like Mg2+ transporter protein zntB GO:0000041,GO:0003674,GO:0005215,GO:0005385,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006829,GO:0008150,GO:0008324,GO:0015075,GO:0015318,GO:0015562,GO:0016020,GO:0016021,GO:0022857,GO:0022883,GO:0022890,GO:0030001,GO:0031224,GO:0031226,GO:0034220,GO:0044425,GO:0044459,GO:0044464,GO:0046583,GO:0046873,GO:0046915,GO:0051179,GO:0051234,GO:0055085,GO:0070838,GO:0071577,GO:0071944,GO:0072509,GO:0072511,GO:0098655,GO:0098660,GO:0098662 - ko:K16074 - - - - ko00000,ko02000 1.A.35.4 - - CorA k59_383161_1 118163.Ple7327_2974 8.49e-38 146.0 COG0021@1|root,COG0021@2|Bacteria,1G0GC@1117|Cyanobacteria,3VIWV@52604|Pleurocapsales 1117|Cyanobacteria G Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate tktA - 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 - - - Transket_pyr,Transketolase_C,Transketolase_N k59_210820_1 1122137.AQXF01000005_gene1112 2.53e-165 496.0 COG0506@1|root,COG4230@1|root,COG0506@2|Bacteria,COG4230@2|Bacteria,1MV93@1224|Proteobacteria,2TQPT@28211|Alphaproteobacteria 28211|Alphaproteobacteria C Oxidizes proline to glutamate for use as a carbon and nitrogen source putA - 1.2.1.88,1.5.5.2 ko:K13821 ko00250,ko00330,ko01100,ko01110,ko01130,map00250,map00330,map01100,map01110,map01130 - R00245,R00707,R00708,R01253,R04444,R04445,R05051 RC00080,RC00083,RC00216,RC00242,RC00255 ko00000,ko00001,ko01000,ko03000 - - - Aldedh,Pro_dh,Pro_dh-DNA_bdg k59_43142_1 929556.Solca_2365 1.77e-16 85.9 COG1361@1|root,COG1520@1|root,COG2373@1|root,COG3291@1|root,COG4655@1|root,COG4932@1|root,COG4935@1|root,COG1361@2|Bacteria,COG1520@2|Bacteria,COG2373@2|Bacteria,COG3291@2|Bacteria,COG4655@2|Bacteria,COG4932@2|Bacteria,COG4935@2|Bacteria,4NDZC@976|Bacteroidetes,1IWX2@117747|Sphingobacteriia 976|Bacteroidetes M SprB repeat - - - - - - - - - - - - CHU_C,PKD,SprB k59_268467_1 1415778.JQMM01000001_gene2242 1.06e-48 159.0 COG4657@1|root,COG4657@2|Bacteria,1MU8X@1224|Proteobacteria,1RQDN@1236|Gammaproteobacteria,1J4WI@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Part of a membrane complex involved in electron transport rnfA - - ko:K03617 - - - - ko00000 - - - Rnf-Nqr k59_268467_2 290398.Csal_2120 1.81e-16 78.2 COG0073@1|root,COG0143@1|root,COG0073@2|Bacteria,COG0143@2|Bacteria,1MUBY@1224|Proteobacteria,1RMYM@1236|Gammaproteobacteria,1XHBT@135619|Oceanospirillales 135619|Oceanospirillales J Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation metG - 6.1.1.10 ko:K01874 ko00450,ko00970,map00450,map00970 M00359,M00360 R03659,R04773 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,tRNA-synt_1g,tRNA_bind k59_942365_1 436308.Nmar_1239 5.03e-141 404.0 COG0379@1|root,arCOG04459@2157|Archaea,41S6Y@651137|Thaumarchaeota 651137|Thaumarchaeota H Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate nadA - 2.5.1.72 ko:K03517 ko00760,ko01100,map00760,map01100 M00115 R04292 RC01119 ko00000,ko00001,ko00002,ko01000 - - - NadA k59_721466_1 316407.85676419 6.46e-99 295.0 COG0859@1|root,COG0859@2|Bacteria,1MYTQ@1224|Proteobacteria,1SYM4@1236|Gammaproteobacteria,3XRAE@561|Escherichia 1236|Gammaproteobacteria M Adds the terminal N-acetyl-D-glucosamine group on the glucose(II) group of LPS waaU GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008194,GO:0008375,GO:0008610,GO:0008653,GO:0008713,GO:0008917,GO:0008920,GO:0009058,GO:0009059,GO:0009103,GO:0009987,GO:0016020,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 - ko:K03277 ko00540,ko01100,map00540,map01100 - - - ko00000,ko00001,ko01000,ko01003,ko01005 - - iAF1260.b3623,iBWG_1329.BWG_3314,iECDH10B_1368.ECDH10B_3805,iECDH1ME8569_1439.ECDH1ME8569_3508,iEcDH1_1363.EcDH1_0082,iJO1366.b3623,iY75_1357.Y75_RS19020 Glyco_transf_9 k59_721466_2 316407.85676420 1.48e-62 202.0 COG3307@1|root,COG3307@2|Bacteria,1R7C4@1224|Proteobacteria,1RSH3@1236|Gammaproteobacteria 1236|Gammaproteobacteria M O-antigen ligase rfaL GO:0000271,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044464,GO:0046401,GO:0071704,GO:0071944,GO:1901135,GO:1901137,GO:1901576,GO:1903509 - ko:K02847 ko00540,ko01100,map00540,map01100 M00080 - - ko00000,ko00001,ko00002,ko01000,ko01005,ko02000 9.B.67.4,9.B.67.5 - - Wzy_C k59_1281080_1 479434.Sthe_3293 4.52e-36 139.0 COG0154@1|root,COG0154@2|Bacteria,2G7KI@200795|Chloroflexi,27YVS@189775|Thermomicrobia 189775|Thermomicrobia J Amidase - - 3.5.1.4 ko:K01426 ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120 - R02540,R03096,R03180,R03909,R05551,R05590 RC00010,RC00100,RC00950,RC01025 ko00000,ko00001,ko01000 - - - Amidase k59_1171327_2 583355.Caka_1226 8.01e-14 70.1 COG0714@1|root,COG0714@2|Bacteria,46S8X@74201|Verrucomicrobia,3K7U3@414999|Opitutae 414999|Opitutae S ATPase family associated with various cellular activities (AAA) - - - ko:K03924 - - - - ko00000,ko01000 - - - AAA_3 k59_1112352_1 1121921.KB898706_gene2452 1.06e-95 310.0 COG1629@1|root,COG1629@2|Bacteria,COG4771@2|Bacteria,1MV8W@1224|Proteobacteria,1RSN6@1236|Gammaproteobacteria,2PMH6@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria P TonB-dependent Receptor Plug Domain - - - - - - - - - - - - Plug,TonB_dep_Rec k59_268481_1 700598.Niako_6291 1.27e-06 56.2 COG3087@1|root,COG3087@2|Bacteria,4PNV5@976|Bacteroidetes 976|Bacteroidetes D Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides - - - - - - - - - - - - - k59_831078_1 1122137.AQXF01000006_gene925 1.43e-97 290.0 COG1192@1|root,COG1192@2|Bacteria,1MVKR@1224|Proteobacteria,2TRZY@28211|Alphaproteobacteria 28211|Alphaproteobacteria D COG1192 ATPases involved in chromosome partitioning mipZ - - ko:K03496 - - - - ko00000,ko03036,ko04812 - - - MipZ k59_1337644_1 394221.Mmar10_0473 7.74e-67 224.0 COG3590@1|root,COG3590@2|Bacteria,1MVNQ@1224|Proteobacteria,2TRU4@28211|Alphaproteobacteria,43W9P@69657|Hyphomonadaceae 28211|Alphaproteobacteria O M13 family peptidase - - 3.4.24.71 ko:K01415,ko:K07386 - - - - ko00000,ko01000,ko01002,ko04147 - - - Peptidase_M13,Peptidase_M13_N k59_1512659_1 876044.IMCC3088_196 3.32e-72 230.0 COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,1RNAM@1236|Gammaproteobacteria,1J5GJ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria G Permease - - - - - - - - - - - - DctM k59_1400015_1 436308.Nmar_0444 4.31e-74 241.0 COG1215@1|root,arCOG01389@2157|Archaea,41SDD@651137|Thaumarchaeota 651137|Thaumarchaeota M Glycosyl transferase family group 2 - - - - - - - - - - - - Glyco_tranf_2_3 k59_831084_1 498211.CJA_0705 2.81e-97 287.0 COG0092@1|root,COG0092@2|Bacteria,1MUAI@1224|Proteobacteria,1RN0P@1236|Gammaproteobacteria,1FGYS@10|Cellvibrio 1236|Gammaproteobacteria J Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation rpsC GO:0000028,GO:0002181,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02982 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - KH_2,Ribosomal_S3_C k59_268491_1 335283.Neut_1808 3.92e-79 258.0 COG5009@1|root,COG5009@2|Bacteria,1MU5A@1224|Proteobacteria,2VHXF@28216|Betaproteobacteria,37235@32003|Nitrosomonadales 28216|Betaproteobacteria M PFAM glycosyl transferase, family 51 mrcA - 2.4.1.129,3.4.16.4 ko:K05366 ko00550,ko01100,ko01501,map00550,map01100,map01501 - - - ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 - PCB_OB,Transgly,Transpeptidase k59_721507_1 1122137.AQXF01000003_gene2275 1.71e-61 202.0 COG0348@1|root,COG0348@2|Bacteria,1MVFY@1224|Proteobacteria,2TRYB@28211|Alphaproteobacteria 28211|Alphaproteobacteria C Cytochrome c oxidase accessory protein ccoG GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - - - - - - - - - - Fer4_18,Fer4_5,FixG_C k59_1060737_2 1242864.D187_004020 1.95e-29 115.0 COG2124@1|root,COG2124@2|Bacteria,1R4VN@1224|Proteobacteria,438EB@68525|delta/epsilon subdivisions,2WYNX@28221|Deltaproteobacteria,2YWRJ@29|Myxococcales 28221|Deltaproteobacteria C Cytochrome P450 - - - - - - - - - - - - p450 k59_1678938_1 330214.NIDE0553 3.89e-17 87.4 COG3210@1|root,COG3210@2|Bacteria 2|Bacteria U domain, Protein - - - - - - - - - - - - Haemagg_act k59_1678943_1 436308.Nmar_1261 6.42e-170 484.0 COG0621@1|root,arCOG01358@2157|Archaea,41SB9@651137|Thaumarchaeota 651137|Thaumarchaeota J MiaB-like tRNA modifying enzyme - - 2.8.4.5 ko:K15865 - - R10649 RC00003,RC03221 ko00000,ko01000,ko03016 - - - Radical_SAM,UPF0004 k59_211936_1 1137281.D778_01248 1.57e-111 322.0 COG1678@1|root,COG1678@2|Bacteria,4NFQA@976|Bacteroidetes,1HXJN@117743|Flavobacteriia 976|Bacteroidetes K transcriptional regulator - - - ko:K07735 - - - - ko00000,ko03000 - - - DUF179 k59_1788982_1 330214.NIDE0302 2.62e-79 251.0 COG0621@1|root,COG0621@2|Bacteria,3J0CD@40117|Nitrospirae 40117|Nitrospirae J Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 rimO - 2.8.4.4 ko:K14441 - - R10652 RC00003,RC03217 ko00000,ko01000,ko03009 - - - Radical_SAM,TRAM,UPF0004 k59_100121_1 1121861.KB899912_gene968 1.69e-44 157.0 COG0204@1|root,COG0204@2|Bacteria 2|Bacteria I Acyl-transferase - - 2.3.1.51,6.2.1.3 ko:K00655,ko:K01897 ko00061,ko00071,ko00561,ko00564,ko01100,ko01110,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map00561,map00564,map01100,map01110,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086,M00089 R01280,R02241,R09381 RC00004,RC00014,RC00037,RC00039 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding,AMP-binding_C,Acyltransferase,NAD_binding_4,PP-binding,Sterile k59_100121_2 344747.PM8797T_10809 5.66e-55 184.0 COG1506@1|root,COG1506@2|Bacteria,2IXED@203682|Planctomycetes 203682|Planctomycetes E alpha/beta hydrolase fold - - - - - - - - - - - - Abhydrolase_3,Peptidase_S9 k59_892749_1 1121405.dsmv_1573 1.11e-81 257.0 COG1236@1|root,COG1236@2|Bacteria,1MUDD@1224|Proteobacteria,42N91@68525|delta/epsilon subdivisions,2WIMM@28221|Deltaproteobacteria,2MIKE@213118|Desulfobacterales 28221|Deltaproteobacteria J RNA-metabolising metallo-beta-lactamase - - - ko:K07576 - - - - ko00000 - - - Beta-Casp,Lactamase_B,Lactamase_B_6,RMMBL k59_1678962_1 435590.BVU_1759 1.75e-20 86.7 COG0838@1|root,COG0838@2|Bacteria,4NQET@976|Bacteroidetes,2FTGA@200643|Bacteroidia,4AQZM@815|Bacteroidaceae 976|Bacteroidetes C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoA GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0008137,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0030964,GO:0032991,GO:0044425,GO:0050136,GO:0055114,GO:0098796,GO:1902494 1.6.5.3 ko:K00330 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q4 k59_832374_1 1286106.MPL1_02016 3.98e-12 63.5 2EFAS@1|root,3393N@2|Bacteria,1NDQN@1224|Proteobacteria,1SSBD@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_1513954_1 316407.85676195 3.8e-184 537.0 COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,1RNBG@1236|Gammaproteobacteria,3XNHM@561|Escherichia 1236|Gammaproteobacteria L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity polA GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008408,GO:0008409,GO:0009058,GO:0009059,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901362,GO:1901363,GO:1901576 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1 k59_1172612_1 1537715.JQFJ01000005_gene70 5.4e-55 192.0 COG4774@1|root,COG4774@2|Bacteria,1MV0X@1224|Proteobacteria,2TTQD@28211|Alphaproteobacteria,2JZZI@204457|Sphingomonadales 204457|Sphingomonadales P receptor - - - - - - - - - - - - Plug,TonB_dep_Rec k59_773575_1 1122137.AQXF01000003_gene1930 9.5e-114 342.0 COG0696@1|root,COG0696@2|Bacteria,1MUQ1@1224|Proteobacteria,2TS6R@28211|Alphaproteobacteria 28211|Alphaproteobacteria G Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate gpmI - 5.4.2.12 ko:K15633 ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003 R01518 RC00536 ko00000,ko00001,ko00002,ko01000 - - - Metalloenzyme,Phosphodiest,iPGM_N k59_773575_2 1122929.KB908216_gene2101 3.98e-07 49.7 COG1576@1|root,COG1576@2|Bacteria,1R9Z2@1224|Proteobacteria,2U95Q@28211|Alphaproteobacteria 28211|Alphaproteobacteria J Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA rlmH - 2.1.1.177 ko:K00783 - - - - ko00000,ko01000,ko03009 - - - SPOUT_MTase k59_1513964_1 67275.JOAP01000019_gene1375 2.49e-31 124.0 COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,2GJY2@201174|Actinobacteria 201174|Actinobacteria L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity polA GO:0003674,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008409,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0030312,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0071944,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901362,GO:1901576 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1 k59_1736716_1 1122137.AQXF01000002_gene604 8.76e-98 304.0 COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,2TQNY@28211|Alphaproteobacteria 28211|Alphaproteobacteria KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance spoT - 2.7.6.5,3.1.7.2 ko:K00951,ko:K01139 ko00230,map00230 - R00336,R00429 RC00002,RC00078 ko00000,ko00001,ko01000,ko03009 - - - ACT_4,HD_4,RelA_SpoT,TGS k59_154802_1 1122225.AULQ01000002_gene543 3.89e-143 419.0 COG0446@1|root,COG0446@2|Bacteria,4NER5@976|Bacteroidetes,1HYF3@117743|Flavobacteriia 976|Bacteroidetes S SusD family - - - ko:K21572 - - - - ko00000,ko02000 8.A.46.1,8.A.46.3 - - SusD-like_3,SusD_RagB k59_1172633_1 316407.85675915 5.29e-20 87.8 COG0814@1|root,COG0814@2|Bacteria,1QB56@1224|Proteobacteria,1RMJ8@1236|Gammaproteobacteria,3XP6Z@561|Escherichia 1236|Gammaproteobacteria E Involved in the import of threonine and serine into the cell, with the concomitant import of a proton (symport system) tdcC GO:0003333,GO:0003674,GO:0005215,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006855,GO:0006865,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0015075,GO:0015077,GO:0015078,GO:0015171,GO:0015175,GO:0015179,GO:0015194,GO:0015195,GO:0015238,GO:0015291,GO:0015293,GO:0015294,GO:0015295,GO:0015318,GO:0015672,GO:0015711,GO:0015804,GO:0015807,GO:0015825,GO:0015826,GO:0015849,GO:0015893,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0022889,GO:0022890,GO:0031224,GO:0031226,GO:0032329,GO:0034220,GO:0042221,GO:0042493,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0098655,GO:0098656,GO:0098660,GO:0098662,GO:1902475,GO:1902600,GO:1903825,GO:1905039 - ko:K03838 - - - - ko00000,ko02000 2.A.42.2.2 - iAPECO1_1312.APECO1_3308,iE2348C_1286.E2348C_3406,iEC55989_1330.EC55989_3533,iECABU_c1320.ECABU_c35330,iECED1_1282.ECED1_3781,iECIAI1_1343.ECIAI1_3265,iECNA114_1301.ECNA114_4343,iECO103_1326.ECO103_3863,iECO26_1355.ECO26_4221,iECOK1_1307.ECOK1_3543,iECP_1309.ECP_3209,iECSE_1348.ECSE_3400,iECSF_1327.ECSF_2956,iECW_1372.ECW_m3385,iEKO11_1354.EKO11_0601,iLF82_1304.LF82_2232,iNRG857_1313.NRG857_15495,iSBO_1134.SBO_2981,iSbBS512_1146.SbBS512_E3241,iUMN146_1321.UM146_00750,iUTI89_1310.UTI89_C3551,iWFL_1372.ECW_m3385,ic_1306.c3874 Aa_trans,Trp_Tyr_perm k59_1172633_2 316407.85675916 1.12e-83 254.0 COG1171@1|root,COG1171@2|Bacteria,1MVWJ@1224|Proteobacteria,1RPGU@1236|Gammaproteobacteria,3XMXP@561|Escherichia 1236|Gammaproteobacteria E Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA tdcB GO:0003674,GO:0003824,GO:0003941,GO:0004793,GO:0004794,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006563,GO:0006565,GO:0006566,GO:0006567,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009066,GO:0009068,GO:0009069,GO:0009071,GO:0009987,GO:0016054,GO:0016597,GO:0016829,GO:0016830,GO:0016832,GO:0016840,GO:0016841,GO:0019752,GO:0019842,GO:0030170,GO:0031406,GO:0036094,GO:0043167,GO:0043168,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 4.3.1.19 ko:K01754 ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230 M00570 R00220,R00996 RC00418,RC02600 ko00000,ko00001,ko00002,ko01000 - - - PALP k59_211989_1 316407.85676111 1.79e-32 114.0 COG1445@1|root,COG1445@2|Bacteria,1RHSU@1224|Proteobacteria,1S6R1@1236|Gammaproteobacteria,3XPSP@561|Escherichia 1236|Gammaproteobacteria G The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II FrwABC PTS system is involved in fructose transport frwB GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0008643,GO:0009401,GO:0015144,GO:0016020,GO:0016740,GO:0016772,GO:0016773,GO:0022804,GO:0022857,GO:0034219,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0090563,GO:0090582 2.7.1.202 ko:K02769,ko:K11202 ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060 M00273,M00306 R03232 RC00017,RC03206 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.2.1 - - PTS_IIB k59_211989_2 316407.85676112 1.63e-105 313.0 COG1299@1|root,COG1299@2|Bacteria,1P0NB@1224|Proteobacteria,1RPQZ@1236|Gammaproteobacteria,3XNJ3@561|Escherichia 1236|Gammaproteobacteria G The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane frwC GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0008643,GO:0009401,GO:0015144,GO:0016020,GO:0016021,GO:0016740,GO:0016772,GO:0016773,GO:0022804,GO:0022857,GO:0031224,GO:0031226,GO:0034219,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0090563 2.7.1.202 ko:K02768,ko:K02769,ko:K02770,ko:K11203 ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060 M00273,M00306 R03232 RC00017,RC03206 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.2.1 - - PTS_EIIC k59_943786_1 396588.Tgr7_2026 2.83e-111 351.0 COG1196@1|root,COG1196@2|Bacteria,1MUAQ@1224|Proteobacteria,1RNA6@1236|Gammaproteobacteria,1WW7V@135613|Chromatiales 135613|Chromatiales D Required for chromosome condensation and partitioning smc - - ko:K03529 - - - - ko00000,ko03036 - - - SMC_N,SMC_hinge k59_269690_1 316407.85676383 2.39e-111 324.0 COG1464@1|root,COG1464@2|Bacteria,1MUVY@1224|Proteobacteria,1RSKH@1236|Gammaproteobacteria,3XNXN@561|Escherichia 1236|Gammaproteobacteria M NLPA lipoprotein nlpA GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K02073 ko02010,map02010 M00238 - - ko00000,ko00001,ko00002,ko02000 3.A.1.24 - - Lipoprotein_9 k59_773603_2 1125863.JAFN01000001_gene2297 1.64e-45 159.0 COG1652@1|root,COG1652@2|Bacteria,1MUBV@1224|Proteobacteria,42QS9@68525|delta/epsilon subdivisions,2WN3H@28221|Deltaproteobacteria 28221|Deltaproteobacteria S LysM domain - - - - - - - - - - - - LysM k59_435558_1 555793.WSK_2625 1.03e-165 468.0 COG0540@1|root,COG0540@2|Bacteria,1MWAB@1224|Proteobacteria,2TRHP@28211|Alphaproteobacteria,2K0IH@204457|Sphingomonadales 204457|Sphingomonadales F Belongs to the ATCase OTCase family pyrB - 2.1.3.2 ko:K00609 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R01397 RC00064,RC02850 ko00000,ko00001,ko00002,ko01000 - - - OTCace,OTCace_N k59_154828_1 1027273.GZ77_16355 4.41e-118 355.0 COG0511@1|root,COG5016@1|root,COG0511@2|Bacteria,COG5016@2|Bacteria,1QTTG@1224|Proteobacteria,1RNG6@1236|Gammaproteobacteria,1XIFS@135619|Oceanospirillales 135619|Oceanospirillales CI Oxaloacetate decarboxylase oadA - 4.1.1.3 ko:K01571 ko00620,ko01100,map00620,map01100 - R00217 RC00040 ko00000,ko00001,ko01000,ko02000 3.B.1.1.1 - - Biotin_lipoyl,HMGL-like,PYC_OADA k59_892812_1 1125863.JAFN01000001_gene1619 1.65e-106 311.0 COG1335@1|root,COG1335@2|Bacteria,1MU5N@1224|Proteobacteria,42Q9J@68525|delta/epsilon subdivisions,2WKMC@28221|Deltaproteobacteria 28221|Deltaproteobacteria Q Isochorismatase family - - - - - - - - - - - - Isochorismatase k59_661950_1 196162.Noca_1727 2.85e-10 64.7 COG0281@1|root,COG0281@2|Bacteria,2GJAJ@201174|Actinobacteria,4DP17@85009|Propionibacteriales 201174|Actinobacteria C Malic enzyme, NAD binding domain - - 1.1.1.38 ko:K00027 ko00620,ko01200,ko02020,map00620,map01200,map02020 - R00214 RC00105 ko00000,ko00001,ko01000 - - - Malic_M,malic k59_384484_1 316407.85675704 1.47e-167 481.0 COG0608@1|root,COG0608@2|Bacteria,1MU1M@1224|Proteobacteria,1RMF4@1236|Gammaproteobacteria,3XP91@561|Escherichia 1236|Gammaproteobacteria L single-stranded-DNA-specific exonuclease RecJ recJ GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0006139,GO:0006259,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008297,GO:0008409,GO:0009314,GO:0009628,GO:0009987,GO:0010165,GO:0010212,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0033554,GO:0034641,GO:0035312,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0045145,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360 - ko:K07462 ko03410,ko03430,ko03440,map03410,map03430,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DHH,DHHA1 k59_892827_1 1131266.ARWQ01000006_gene233 1.81e-62 194.0 arCOG05400@1|root,arCOG05400@2157|Archaea,41SQH@651137|Thaumarchaeota 651137|Thaumarchaeota S PFAM Polyketide cyclase dehydrase and lipid transport - - - - - - - - - - - - Polyketide_cyc2 k59_892827_2 1229909.NSED_03110 3.22e-06 48.1 arCOG01390@1|root,arCOG01390@2157|Archaea,41S7Q@651137|Thaumarchaeota 651137|Thaumarchaeota M Glycosyl transferase family 21 - - - - - - - - - - - - Glycos_transf_2 k59_1624050_1 933115.GPDM_15694 0.000181 50.4 COG0834@1|root,COG0834@2|Bacteria,1TT16@1239|Firmicutes,4HD16@91061|Bacilli,26EPC@186818|Planococcaceae 91061|Bacilli ET Belongs to the bacterial solute-binding protein 3 family artP - - ko:K02030 - M00236 - - ko00000,ko00002,ko02000 3.A.1.3 - - SBP_bac_3 k59_722941_1 876044.IMCC3088_2549 5.33e-29 117.0 COG2271@1|root,COG2271@2|Bacteria,1QTW2@1224|Proteobacteria,1T3J3@1236|Gammaproteobacteria 1236|Gammaproteobacteria G COG0477 Permeases of the major facilitator superfamily - - - - - - - - - - - - MFS_1 k59_327845_1 414684.RC1_1453 2.55e-56 182.0 COG0740@1|root,COG0740@2|Bacteria,1RBNX@1224|Proteobacteria,2U5ZH@28211|Alphaproteobacteria,2JUZ1@204441|Rhodospirillales 204441|Rhodospirillales O Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins - - 3.4.21.92 ko:K01358 ko04112,ko04212,map04112,map04212 - - - ko00000,ko00001,ko01000,ko01002 - - - CLP_protease k59_327845_2 880073.Calab_0813 1.31e-11 66.2 COG1199@1|root,COG1199@2|Bacteria 2|Bacteria L ATP-dependent helicase activity - - 3.6.4.12 ko:K10844 ko03022,ko03420,map03022,map03420 M00290 - - ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - DEAD,DEAD_2,Helicase_C_2 k59_384500_1 634452.APA01_24220 6.86e-80 264.0 COG0403@1|root,COG1003@1|root,COG0403@2|Bacteria,COG1003@2|Bacteria,1MUDP@1224|Proteobacteria,2TSFF@28211|Alphaproteobacteria,2JPMB@204441|Rhodospirillales 204441|Rhodospirillales E The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor gcvP - 1.4.4.2 ko:K00281,ko:K00283 ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200 M00532 R01221,R03425 RC00022,RC00929,RC02834,RC02880 ko00000,ko00001,ko00002,ko01000 - - - Aminotran_5,GDC-P k59_1452396_1 1229909.NSED_06250 3.39e-09 53.5 arCOG10955@1|root,arCOG10955@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_1624051_1 398579.Spea_1983 1.13e-113 360.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,2QA13@267890|Shewanellaceae 1236|Gammaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family acrF - - ko:K18138 ko01501,ko01503,map01501,map01503 M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000 2.A.6.2 - - ACR_tran k59_154863_1 1122137.AQXF01000003_gene1918 4.41e-148 439.0 COG1198@1|root,COG1198@2|Bacteria,1MUUZ@1224|Proteobacteria,2TQTQ@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA priA - - ko:K04066 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,Helicase_C k59_435595_1 203275.BFO_1521 2.01e-06 49.3 COG1208@1|root,COG1208@2|Bacteria,4NMJ5@976|Bacteroidetes,2FNEE@200643|Bacteroidia,22XKJ@171551|Porphyromonadaceae 976|Bacteroidetes JM COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits (eIF-2Bgamma eIF-2Bepsilon) hddC - - - - - - - - - - - NTP_transferase k59_943828_1 977880.RALTA_A1499 6.61e-58 191.0 COG0084@1|root,COG0084@2|Bacteria,1MUC0@1224|Proteobacteria,2VHCT@28216|Betaproteobacteria,1K1E9@119060|Burkholderiaceae 28216|Betaproteobacteria L TIGRFAM hydrolase, TatD family ycfH - - ko:K03424 - - - - ko00000,ko01000 - - - TatD_DNase k59_1679067_1 518766.Rmar_0956 8.23e-75 238.0 COG1301@1|root,COG1301@2|Bacteria,4NDUU@976|Bacteroidetes,1FIV5@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes C Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family gltP - - - - - - - - - - - SDF k59_1060847_1 330214.NIDE3255 1.55e-126 390.0 COG0243@1|root,COG0243@2|Bacteria 2|Bacteria C molybdopterin cofactor binding ddhA GO:0005575,GO:0005623,GO:0042597,GO:0044464 1.17.99.2,1.7.5.1,1.8.2.4 ko:K00370,ko:K10700,ko:K16964,ko:K17050 ko00642,ko00910,ko00920,ko01100,ko01120,ko01220,ko02020,map00642,map00910,map00920,map01100,map01120,map01220,map02020 M00529,M00530,M00804 R00798,R01106,R05745,R09497,R09500 RC00275,RC02555,RC02812 ko00000,ko00001,ko00002,ko01000,ko02000 5.A.3.1,5.A.3.8,5.A.3.9 - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding,TAT_signal k59_269736_1 1122137.AQXF01000003_gene2223 3.12e-86 263.0 COG1752@1|root,COG1752@2|Bacteria,1PUT1@1224|Proteobacteria,2U6DW@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Patatin-like phospholipase - - - ko:K07001 - - - - ko00000 - - - Patatin k59_1624059_1 864069.MicloDRAFT_00034510 1.3e-50 169.0 COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,2TQTP@28211|Alphaproteobacteria,1JW30@119045|Methylobacteriaceae 28211|Alphaproteobacteria L transposase IS116 IS110 IS902 family - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_1113642_1 617140.AJZE01000060_gene4489 6.7e-26 112.0 COG2200@1|root,COG2203@1|root,COG2200@2|Bacteria,COG2203@2|Bacteria,1RGKE@1224|Proteobacteria,1T1I8@1236|Gammaproteobacteria,1XUWZ@135623|Vibrionales 135623|Vibrionales T GGDEF family - - 3.1.4.52 ko:K20962 ko05111,map05111 - - - ko00000,ko00001,ko01000 - - - EAL,GAF,GAF_2,GGDEF k59_1736766_1 199310.c3912 1.4e-138 395.0 COG0826@1|root,COG0826@2|Bacteria,1MWFW@1224|Proteobacteria,1RMWM@1236|Gammaproteobacteria,3XMXE@561|Escherichia 1236|Gammaproteobacteria O peptidase activity yhbV - - - - - - - - - - - Peptidase_U32 k59_384526_1 1229909.NSED_09355 8.17e-46 149.0 COG1761@1|root,arCOG04111@2157|Archaea,41SV9@651137|Thaumarchaeota 651137|Thaumarchaeota K RNA polymerase Rpb3/Rpb11 dimerisation domain - - 2.7.7.6 ko:K03056 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00184 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021 - - - RNA_pol_L_2 k59_384526_2 1229909.NSED_09360 3.59e-65 202.0 arCOG08749@1|root,arCOG08749@2157|Archaea,41SRV@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1745599_2 1317124.DW2_02959 1.03e-41 150.0 COG2807@1|root,COG2807@2|Bacteria,1QU0F@1224|Proteobacteria,2TTB4@28211|Alphaproteobacteria 28211|Alphaproteobacteria P Major facilitator superfamily MA20_10260 - - - - - - - - - - - MFS_1 k59_952914_1 460265.Mnod_2283 6.94e-51 174.0 COG2358@1|root,COG2358@2|Bacteria,1NRH6@1224|Proteobacteria,2TT34@28211|Alphaproteobacteria,1JTQE@119045|Methylobacteriaceae 28211|Alphaproteobacteria S NMT1-like family - - - ko:K07080 - - - - ko00000 - - - NMT1_3 k59_733109_2 314287.GB2207_06293 4.59e-106 322.0 COG0760@1|root,COG0760@2|Bacteria,1MVB3@1224|Proteobacteria,1RMWU@1236|Gammaproteobacteria,1J4I7@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation surA GO:0000413,GO:0003674,GO:0003755,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006457,GO:0006458,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0016853,GO:0016859,GO:0018193,GO:0018208,GO:0019538,GO:0022607,GO:0030288,GO:0030313,GO:0031647,GO:0031975,GO:0033218,GO:0036211,GO:0042277,GO:0042597,GO:0043163,GO:0043165,GO:0043170,GO:0043412,GO:0044085,GO:0044091,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0044764,GO:0045229,GO:0050821,GO:0051082,GO:0051084,GO:0051085,GO:0051704,GO:0060274,GO:0061024,GO:0061077,GO:0065007,GO:0065008,GO:0071704,GO:0071709,GO:0071840,GO:0140096,GO:1901564 5.2.1.8 ko:K03771 - - - - ko00000,ko01000,ko03110 - - - Rotamase,Rotamase_3,SurA_N k59_1411801_1 436308.Nmar_1348 2.56e-64 196.0 COG0361@1|root,arCOG01179@2157|Archaea 2157|Archaea J Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits eif1a - - ko:K03236 ko03013,map03013 - - - ko00000,ko00001,ko03012 - - - eIF-1a k59_1293031_1 1453501.JELR01000002_gene940 1.9e-107 320.0 COG0407@1|root,COG0407@2|Bacteria,1MUG1@1224|Proteobacteria,1RMDH@1236|Gammaproteobacteria,46563@72275|Alteromonadaceae 1236|Gammaproteobacteria H Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III hemE GO:0003674,GO:0003824,GO:0004853,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006536,GO:0006725,GO:0006778,GO:0006779,GO:0006780,GO:0006782,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009064,GO:0009987,GO:0016053,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019353,GO:0019438,GO:0019752,GO:0033013,GO:0033014,GO:0033526,GO:0034641,GO:0042168,GO:0042440,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046394,GO:0046483,GO:0046501,GO:0046502,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 4.1.1.37 ko:K01599 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R03197,R04972 RC00872 ko00000,ko00001,ko00002,ko01000 - - iPC815.YPO3734,iSBO_1134.SBO_4018 URO-D k59_500888_1 452637.Oter_3423 4.85e-36 137.0 2EDHY@1|root,30P5Z@2|Bacteria,46XU5@74201|Verrucomicrobia,3K84S@414999|Opitutae 414999|Opitutae - - - - - - - - - - - - - - - k59_54586_1 626887.J057_14130 1.05e-118 353.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,463YY@72275|Alteromonadaceae 1236|Gammaproteobacteria T COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains glnG GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - ko:K07712 ko02020,map02020 M00497 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_1009282_1 1279017.AQYJ01000026_gene55 1.94e-139 420.0 COG1049@1|root,COG1049@2|Bacteria,1MVCR@1224|Proteobacteria,1RNMC@1236|Gammaproteobacteria,46445@72275|Alteromonadaceae 1236|Gammaproteobacteria C Belongs to the aconitase IPM isomerase family acnB - 4.2.1.3,4.2.1.99 ko:K01682 ko00020,ko00630,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00173 R01324,R01325,R01900,R04425 RC00497,RC00498,RC00618,RC01153 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase,Aconitase_2_N,Aconitase_B_N k59_1123726_1 1144305.PMI02_00179 6.78e-105 324.0 COG2200@1|root,COG4252@1|root,COG2200@2|Bacteria,COG4252@2|Bacteria,1N299@1224|Proteobacteria,2U5C8@28211|Alphaproteobacteria,2K2WP@204457|Sphingomonadales 204457|Sphingomonadales T Putative diguanylate phosphodiesterase - - - - - - - - - - - - CHASE2,EAL k59_1581603_1 1122137.AQXF01000009_gene17 1.26e-103 318.0 COG0480@1|root,COG0480@2|Bacteria,1MUCV@1224|Proteobacteria,2TQVI@28211|Alphaproteobacteria 28211|Alphaproteobacteria J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome fusA - - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2 k59_280154_1 1415778.JQMM01000001_gene118 1.91e-181 513.0 COG4972@1|root,COG4972@2|Bacteria,1MX8P@1224|Proteobacteria,1RN8S@1236|Gammaproteobacteria,1J4VC@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria NU COG4972 Tfp pilus assembly protein, ATPase PilM pilM - - ko:K02662 - - - - ko00000,ko02035,ko02044 - - - PilM_2 k59_1524087_1 946483.Cenrod_0449 2.83e-204 583.0 COG0376@1|root,COG0376@2|Bacteria,1MUBF@1224|Proteobacteria,2VH5H@28216|Betaproteobacteria,4A9PE@80864|Comamonadaceae 28216|Betaproteobacteria P Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity katG - 1.11.1.21 ko:K03782 ko00360,ko00380,ko00940,ko00983,ko01100,ko01110,map00360,map00380,map00940,map00983,map01100,map01110 - R00602,R00698,R02596,R02670,R03919,R04007,R07443,R11906 RC00034,RC00213,RC00767,RC02141 ko00000,ko00001,ko01000 - - - peroxidase k59_1293048_2 717774.Marme_3460 1.76e-95 292.0 COG1158@1|root,COG1158@2|Bacteria,1MUCF@1224|Proteobacteria,1RP95@1236|Gammaproteobacteria,1XHZA@135619|Oceanospirillales 135619|Oceanospirillales K Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template rho - - ko:K03628 ko03018,map03018 - - - ko00000,ko00001,ko03019,ko03021 - - - ATP-synt_ab,Rho_N,Rho_RNA_bind k59_1349001_1 314225.ELI_07735 2.24e-12 73.6 COG0784@1|root,COG4191@1|root,COG0784@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TQQ9@28211|Alphaproteobacteria,2K0WG@204457|Sphingomonadales 204457|Sphingomonadales T Histidine kinase - - 2.7.13.3 ko:K13587 ko02020,ko04112,map02020,map04112 M00512 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA,PAS_4,PAS_8,Response_reg k59_1182506_1 1304874.JAFY01000002_gene512 4.21e-27 115.0 COG0834@1|root,COG2199@1|root,COG0834@2|Bacteria,COG3706@2|Bacteria,3TC0A@508458|Synergistetes 508458|Synergistetes ET Bacterial periplasmic substrate-binding proteins - - - - - - - - - - - - GGDEF,SBP_bac_3 k59_1746588_1 199310.c0490 4.06e-30 116.0 COG1785@1|root,COG1785@2|Bacteria,1MXI2@1224|Proteobacteria,1RNG8@1236|Gammaproteobacteria,3XP3C@561|Escherichia 1236|Gammaproteobacteria P Belongs to the alkaline phosphatase family phoA GO:0000287,GO:0003674,GO:0003824,GO:0004035,GO:0004721,GO:0005488,GO:0005575,GO:0005623,GO:0006464,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009987,GO:0016311,GO:0016491,GO:0016695,GO:0016787,GO:0016788,GO:0016791,GO:0019538,GO:0030288,GO:0030313,GO:0030613,GO:0031975,GO:0033748,GO:0036211,GO:0042578,GO:0042597,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0046872,GO:0046914,GO:0055114,GO:0071704,GO:0140096,GO:1901564 3.1.3.1 ko:K01077 ko00730,ko00790,ko01100,ko02020,map00730,map00790,map01100,map02020 M00126 R02135,R04620 RC00017 ko00000,ko00001,ko00002,ko00537,ko01000,ko04147 - - iECO111_1330.ECO111_0413,iECO26_1355.ECO26_0416 Alk_phosphatase k59_1746588_2 199310.c0491 3.97e-36 124.0 2E4IS@1|root,32ZDU@2|Bacteria,1N7N3@1224|Proteobacteria,1S6R3@1236|Gammaproteobacteria,3XPNN@561|Escherichia 1236|Gammaproteobacteria S psiF repeat psiF - - - - - - - - - - - PsiF_repeat k59_1009295_1 13690.CP98_01826 6.64e-37 143.0 COG1960@1|root,COG1960@2|Bacteria,1R6EH@1224|Proteobacteria,2U2J9@28211|Alphaproteobacteria,2K0SA@204457|Sphingomonadales 204457|Sphingomonadales I Acyl-CoA dehydrogenase, middle domain - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_903074_1 795666.MW7_0317 8.41e-83 257.0 COG1622@1|root,COG2010@1|root,COG1622@2|Bacteria,COG2010@2|Bacteria,1MWHZ@1224|Proteobacteria,2VH9M@28216|Betaproteobacteria,1K2B7@119060|Burkholderiaceae 28216|Betaproteobacteria C Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) coxB - 1.9.3.1 ko:K02275 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.4,3.D.4.6 - - COX2,COX2_TM,Cytochrome_CBB3,OmpA k59_110597_1 768671.ThimaDRAFT_0880 2.95e-64 204.0 COG0424@1|root,COG0424@2|Bacteria,1RH6H@1224|Proteobacteria,1S41D@1236|Gammaproteobacteria,1WY2J@135613|Chromatiales 135613|Chromatiales D Maf-like protein - - - ko:K06287 - - - - ko00000 - - - Maf k59_1799052_1 593907.Celgi_2142 6.67e-67 212.0 COG1116@1|root,COG1116@2|Bacteria,2GN33@201174|Actinobacteria,4F2DR@85016|Cellulomonadaceae 201174|Actinobacteria P PFAM ABC transporter related - - - ko:K02049 - M00188 - - ko00000,ko00002,ko02000 3.A.1.16,3.A.1.17 - - ABC_tran k59_1123746_1 744980.TRICHSKD4_2688 7.76e-85 267.0 COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,2TSTW@28211|Alphaproteobacteria 28211|Alphaproteobacteria EH Belongs to the TPP enzyme family ilvB - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_1799076_1 316407.85676038 2.1e-110 348.0 COG3164@1|root,COG3164@2|Bacteria,1MXWF@1224|Proteobacteria,1RNUK@1236|Gammaproteobacteria,3XMN7@561|Escherichia 1236|Gammaproteobacteria S Protein of unknown function yhdP GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0030288,GO:0030313,GO:0031224,GO:0031226,GO:0031975,GO:0042597,GO:0044425,GO:0044459,GO:0044464,GO:0071944 - - - - - - - - - - AsmA_2,DUF3971 k59_783388_1 1122137.AQXF01000002_gene286 1.37e-72 229.0 COG1612@1|root,COG1612@2|Bacteria,1MVJ4@1224|Proteobacteria,2TR0M@28211|Alphaproteobacteria 28211|Alphaproteobacteria O Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group ctaA - - ko:K02259 ko00190,ko00860,ko01100,ko01110,ko02020,ko04714,map00190,map00860,map01100,map01110,map02020,map04714 M00154 R07412 RC00769 ko00000,ko00001,ko00002,ko03029 3.D.4.4 - - COX15-CtaA k59_1634441_1 1079460.ATTQ01000011_gene2972 6.57e-33 124.0 COG0654@1|root,COG0654@2|Bacteria,1MV8T@1224|Proteobacteria,2TRB8@28211|Alphaproteobacteria,4B8F7@82115|Rhizobiaceae 28211|Alphaproteobacteria CH 4-hydroxybenzoate pobA GO:0000166,GO:0003674,GO:0003824,GO:0004497,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016705,GO:0016709,GO:0018659,GO:0036094,GO:0043167,GO:0043168,GO:0048037,GO:0050660,GO:0050662,GO:0055114,GO:0071949,GO:0097159,GO:1901265,GO:1901363 1.14.13.2 ko:K00481 ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220 - R01298 RC00046 ko00000,ko00001,ko01000 - - - FAD_binding_3 k59_222096_1 1122137.AQXF01000003_gene1967 6.74e-98 310.0 COG1629@1|root,COG4774@1|root,COG1629@2|Bacteria,COG4774@2|Bacteria,1MWS3@1224|Proteobacteria,2TWDV@28211|Alphaproteobacteria 28211|Alphaproteobacteria P TonB-dependent receptor - - - - - - - - - - - - Plug,TonB_dep_Rec k59_1182553_1 1535422.ND16A_3811 2.04e-92 285.0 COG1288@1|root,COG1288@2|Bacteria,1MY1J@1224|Proteobacteria,1RS2M@1236|Gammaproteobacteria 1236|Gammaproteobacteria S C4-dicarboxylate anaerobic - - - - - - - - - - - - DcuC k59_1238278_1 1042375.AFPL01000052_gene380 1.81e-25 109.0 COG0591@1|root,COG4191@1|root,COG0591@2|Bacteria,COG4191@2|Bacteria,1QTSW@1224|Proteobacteria,1T1G2@1236|Gammaproteobacteria,4643M@72275|Alteromonadaceae 1236|Gammaproteobacteria T COG0591 Na proline symporter cbrA - - - - - - - - - - - HATPase_c,HisKA,PAS k59_1238278_2 1121940.AUDZ01000013_gene812 7.65e-17 80.5 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,1XHFG@135619|Oceanospirillales 135619|Oceanospirillales T regulator hydG - - - - - - - - - - - Response_reg,Sigma54_activat k59_1746639_1 448385.sce4705 2.37e-109 323.0 COG0437@1|root,COG0437@2|Bacteria,1NBU3@1224|Proteobacteria,42MNU@68525|delta/epsilon subdivisions,2WJRG@28221|Deltaproteobacteria 28221|Deltaproteobacteria C PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein dsrO - - ko:K00184 - - - - ko00000 5.A.3 - - Fer4_11,Fer4_4 k59_1746639_2 1123070.KB899251_gene659 2.82e-29 111.0 COG2010@1|root,COG2010@2|Bacteria,46VBT@74201|Verrucomicrobia,2IUG7@203494|Verrucomicrobiae 203494|Verrucomicrobiae C Cytochrome c - - - - - - - - - - - - - k59_1799098_2 1117314.PCIT_15675 3.12e-12 72.0 2E0PN@1|root,32W8D@2|Bacteria,1N3FT@1224|Proteobacteria,1S2BG@1236|Gammaproteobacteria,2Q28I@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria S Protein of unknown function (DUF3108) - - - - - - - - - - - - DUF3108 k59_1238294_1 236097.ADG881_1222 1.71e-31 113.0 COG1765@1|root,COG1765@2|Bacteria,1RCZW@1224|Proteobacteria,1S3XF@1236|Gammaproteobacteria,1XKAV@135619|Oceanospirillales 135619|Oceanospirillales O redox protein, regulator of disulfide bond formation - - - ko:K07397 - - - - ko00000 - - - OsmC k59_1238294_2 314287.GB2207_08016 7.84e-22 90.9 COG0664@1|root,COG0664@2|Bacteria,1MXID@1224|Proteobacteria,1RMIZ@1236|Gammaproteobacteria,1J52V@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria K COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases crp GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0007154,GO:0007584,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009605,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0009991,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0016070,GO:0017076,GO:0018130,GO:0019001,GO:0019219,GO:0019222,GO:0019438,GO:0030551,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0031667,GO:0031668,GO:0031669,GO:0031670,GO:0032553,GO:0032555,GO:0032561,GO:0032774,GO:0032991,GO:0032993,GO:0034641,GO:0034645,GO:0034654,GO:0035438,GO:0036094,GO:0042221,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0045013,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0045990,GO:0046483,GO:0046983,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0051716,GO:0060255,GO:0061984,GO:0061985,GO:0065007,GO:0070887,GO:0071496,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097367,GO:0097659,GO:0140110,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:2000112,GO:2000113,GO:2001141 - ko:K10914 ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111 - - - ko00000,ko00001,ko03000 - - - Crp,cNMP_binding k59_500956_1 1004149.AFOE01000028_gene1807 1.52e-73 262.0 COG1520@1|root,COG3209@1|root,COG5184@1|root,COG1520@2|Bacteria,COG3209@2|Bacteria,COG5184@2|Bacteria,4NE5D@976|Bacteroidetes,1HYTK@117743|Flavobacteriia 976|Bacteroidetes M RHS repeat-associated core domain - - - - - - - - - - - - - k59_954019_1 349521.HCH_01497 1.84e-14 73.9 COG1030@1|root,COG1030@2|Bacteria,1MUJN@1224|Proteobacteria,1RN3U@1236|Gammaproteobacteria,1XIN1@135619|Oceanospirillales 135619|Oceanospirillales O NfeD-like C-terminal, partner-binding - - - ko:K07403 - - - - ko00000 - - - NfeD k59_954019_2 696747.NIES39_F00550 1.23e-34 127.0 COG0031@1|root,COG0031@2|Bacteria,1G0T4@1117|Cyanobacteria,1H7K5@1150|Oscillatoriales 1117|Cyanobacteria E Cysteine synthase cysM - 2.5.1.47 ko:K01738 ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230 M00021 R00897,R03601,R04859 RC00020,RC02814,RC02821 ko00000,ko00001,ko00002,ko01000 - - - PALP k59_783412_1 1144305.PMI02_00268 9.24e-93 294.0 COG1629@1|root,COG4771@2|Bacteria,1MUNK@1224|Proteobacteria,2TRCG@28211|Alphaproteobacteria,2K0ND@204457|Sphingomonadales 204457|Sphingomonadales P receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_1293113_1 1453501.JELR01000002_gene678 1.02e-58 191.0 COG0682@1|root,COG0682@2|Bacteria,1MVE3@1224|Proteobacteria,1RMVK@1236|Gammaproteobacteria,4655B@72275|Alteromonadaceae 1236|Gammaproteobacteria M Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins lgt GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0008961,GO:0009058,GO:0009059,GO:0009898,GO:0009987,GO:0016020,GO:0016021,GO:0016740,GO:0016757,GO:0019538,GO:0031224,GO:0031226,GO:0034645,GO:0036211,GO:0042157,GO:0042158,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0071704,GO:0071944,GO:0098552,GO:0098562,GO:0140096,GO:1901564,GO:1901566,GO:1901576 - ko:K13292 - - - - ko00000,ko01000 - - - LGT k59_1799107_1 1122137.AQXF01000003_gene1910 4.15e-121 354.0 COG0026@1|root,COG0026@2|Bacteria,1MU70@1224|Proteobacteria,2TRSV@28211|Alphaproteobacteria 28211|Alphaproteobacteria F Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) purK GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 6.3.4.18 ko:K01589 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R07404 RC01927 ko00000,ko00001,ko00002,ko01000 - - - ATP-grasp k59_672030_1 470.IX87_10340 6.25e-62 208.0 COG2194@1|root,COG2194@2|Bacteria,1MWS7@1224|Proteobacteria,1RMNG@1236|Gammaproteobacteria,3NJEC@468|Moraxellaceae 1236|Gammaproteobacteria S Domain of unknown function (DUF1705) eptA - 2.7.8.43 ko:K03760,ko:K19353 ko00540,ko01503,map00540,map01503 M00722 R11555,R11556,R11557 RC00002 ko00000,ko00001,ko00002,ko01000,ko01005 - - - DUF1705,Sulfatase k59_1746659_1 330214.NIDE4207 1.24e-151 436.0 COG0463@1|root,COG0463@2|Bacteria 2|Bacteria M Glycosyl transferase, family 2 - - 2.4.1.268 ko:K21349 - - - - ko00000,ko01000 - GT81 - Glycos_transf_2 k59_1746662_1 366394.Smed_6258 5.88e-99 295.0 COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,1P76X@1224|Proteobacteria,2U16U@28211|Alphaproteobacteria,4BC2J@82115|Rhizobiaceae 28211|Alphaproteobacteria L Transposase and inactivated - - - - - - - - - - - - DDE_3,HTH_23 k59_1009382_1 290397.Adeh_0150 1.27e-15 77.8 COG3715@1|root,COG3715@2|Bacteria 2|Bacteria G PTS system - - - ko:K02795 ko00051,ko00520,ko01100,ko02060,map00051,map00520,map01100,map02060 M00276 R02630 RC00017,RC03206 ko00000,ko00001,ko00002,ko02000 4.A.6.1 - - EII-Sor k59_222132_1 95619.PM1_0225615 6.26e-07 50.8 COG4591@1|root,COG4591@2|Bacteria,1MVV7@1224|Proteobacteria,1RMP9@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Lipoprotein releasing system transmembrane protein lolC - - ko:K09808 ko02010,map02010 M00255 - - ko00000,ko00001,ko00002,ko02000 3.A.1.125 - - FtsX,MacB_PCD k59_222132_2 1439940.BAY1663_03467 4.03e-13 66.6 2ENKU@1|root,33G87@2|Bacteria,1NMH6@1224|Proteobacteria,1SGDI@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_164945_1 1216007.AOPM01000029_gene3516 5e-14 72.0 COG0454@1|root,COG0456@2|Bacteria,1RIE6@1224|Proteobacteria,1S9G0@1236|Gammaproteobacteria,2Q22I@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria K This enzyme acetylates the N-terminal alanine of ribosomal protein S18 rimI GO:0003674,GO:0003824,GO:0004596,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006473,GO:0006474,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008999,GO:0009987,GO:0010467,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0017189,GO:0018193,GO:0018194,GO:0019538,GO:0031365,GO:0034212,GO:0036211,GO:0043170,GO:0043412,GO:0043543,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0051604,GO:0071704,GO:1901564 2.3.1.128 ko:K03789 - - - - ko00000,ko01000,ko03009 - - - Acetyltransf_1 k59_843064_1 1382356.JQMP01000004_gene319 4.37e-26 111.0 COG3653@1|root,COG3653@2|Bacteria,2G86A@200795|Chloroflexi,27ZD5@189775|Thermomicrobia 189775|Thermomicrobia Q Amidohydrolase family - - - - - - - - - - - - Amidohydro_3 k59_394950_1 1125863.JAFN01000001_gene1802 1.08e-122 368.0 COG0516@1|root,COG0517@1|root,COG0516@2|Bacteria,COG0517@2|Bacteria,1MUJM@1224|Proteobacteria,42M2M@68525|delta/epsilon subdivisions,2WJ5H@28221|Deltaproteobacteria 28221|Deltaproteobacteria F Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth guaB - 1.1.1.205 ko:K00088 ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 M00050 R01130,R08240 RC00143,RC02207 ko00000,ko00001,ko00002,ko01000,ko04147 - - - CBS,IMPDH,NMO k59_1524186_1 768066.HELO_3779 8.92e-28 110.0 COG0113@1|root,COG0113@2|Bacteria,1MWMW@1224|Proteobacteria,1RP6Q@1236|Gammaproteobacteria,1XI8U@135619|Oceanospirillales 135619|Oceanospirillales H Belongs to the ALAD family hemB - 4.2.1.24 ko:K01698 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R00036 RC00918,RC01781 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ALAD k59_1524186_2 983545.Glaag_2676 1.45e-29 111.0 COG1595@1|root,COG1595@2|Bacteria,1R9ZN@1224|Proteobacteria,1S27W@1236|Gammaproteobacteria,466M0@72275|Alteromonadaceae 1236|Gammaproteobacteria K Belongs to the sigma-70 factor family. ECF subfamily sigV - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 k59_280247_2 644966.Tmar_1596 4.3e-91 289.0 COG0843@1|root,COG0843@2|Bacteria,1TP2U@1239|Firmicutes,24YCV@186801|Clostridia 186801|Clostridia C Cytochrome C and Quinol oxidase polypeptide I - - 1.10.3.12,1.9.3.1 ko:K02274,ko:K02827 ko00190,ko01100,map00190,map01100 M00155,M00416 R00081,R09492 RC00016,RC00819 ko00000,ko00001,ko00002,ko01000 3.D.4.1,3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6 - - COX1 k59_1123812_1 443906.CMM_2236 3.69e-27 109.0 COG0020@1|root,COG0020@2|Bacteria,2GJCP@201174|Actinobacteria,4FKY2@85023|Microbacteriaceae 201174|Actinobacteria I Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids uppS1 GO:0000287,GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006066,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016020,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0030145,GO:0033850,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0046872,GO:0046914,GO:0071704,GO:0071944,GO:1901576,GO:1901615,GO:1901617 2.5.1.31,2.5.1.68 ko:K00806,ko:K12503 ko00900,ko01110,map00900,map01110 - R06447,R08528 RC00279,RC02839 ko00000,ko00001,ko01000,ko01006 - - - Prenyltransf k59_1009409_1 10224.XP_006823104.1 6.7e-10 67.8 KOG3645@1|root,KOG3645@2759|Eukaryota,38BP2@33154|Opisthokonta,3BD2A@33208|Metazoa,3CS0W@33213|Bilateria 33208|Metazoa T Neuronal acetylcholine receptor subunit - - - - - - - - - - - - Neur_chan_LBD,Neur_chan_memb k59_1524198_1 743836.AYNA01000096_gene1956 2.21e-36 137.0 COG1262@1|root,COG1262@2|Bacteria,1MUNC@1224|Proteobacteria,2TQXE@28211|Alphaproteobacteria,36XC2@31993|Methylocystaceae 28211|Alphaproteobacteria S DinB superfamily - - - - - - - - - - - - DinB_2,FGE-sulfatase,Methyltransf_33 k59_1524198_2 1123270.ATUR01000006_gene196 5.38e-22 92.4 COG1309@1|root,COG1309@2|Bacteria,1Q53U@1224|Proteobacteria,2UPD9@28211|Alphaproteobacteria,2K556@204457|Sphingomonadales 204457|Sphingomonadales K Bacterial regulatory proteins, tetR family - - - - - - - - - - - - TetR_N k59_1123814_1 1390370.O203_09115 1.75e-41 153.0 COG4591@1|root,COG4591@2|Bacteria,1MVV7@1224|Proteobacteria,1RMP9@1236|Gammaproteobacteria,1YDCA@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria M MacB-like periplasmic core domain lolE - - ko:K09808 ko02010,map02010 M00255 - - ko00000,ko00001,ko00002,ko02000 3.A.1.125 - - FtsX,MacB_PCD k59_620271_1 999411.HMPREF1092_00387 9.32e-05 49.7 COG2148@1|root,COG2148@2|Bacteria,1TP7M@1239|Firmicutes,24870@186801|Clostridia,36EMM@31979|Clostridiaceae 186801|Clostridia M sugar transferase cpsE - - - - - - - - - - - Bac_transf,CoA_binding_3 k59_1349070_1 1123054.KB907752_gene2589 8.91e-12 70.5 COG0596@1|root,COG0596@2|Bacteria,1R6KU@1224|Proteobacteria,1RNTQ@1236|Gammaproteobacteria 1236|Gammaproteobacteria I Alpha beta hydrolase - - - - - - - - - - - - Abhydrolase_1,Abhydrolase_4 k59_620281_1 404589.Anae109_1476 4.1e-39 149.0 COG0784@1|root,COG0784@2|Bacteria,1QYG7@1224|Proteobacteria,43E8C@68525|delta/epsilon subdivisions,2X7NA@28221|Deltaproteobacteria,2Z11B@29|Myxococcales 28221|Deltaproteobacteria T cheY-homologous receiver domain - - - - - - - - - - - - Response_reg k59_1746699_1 886293.Sinac_3352 3.49e-26 108.0 COG0524@1|root,COG0524@2|Bacteria,2IZDG@203682|Planctomycetes 203682|Planctomycetes G COG0524 Sugar kinases, ribokinase - - 2.7.1.4 ko:K00847 ko00051,ko00500,ko00520,ko01100,map00051,map00500,map00520,map01100 - R00760,R00867,R03920 RC00002,RC00017 ko00000,ko00001,ko01000 - - - PfkB k59_1070878_2 1120705.FG95_02415 7.73e-46 164.0 COG0006@1|root,COG0006@2|Bacteria,1MUZS@1224|Proteobacteria,2TQXN@28211|Alphaproteobacteria,2K0TU@204457|Sphingomonadales 204457|Sphingomonadales E aminopeptidase - - 3.4.11.9 ko:K01262 - - - - ko00000,ko01000,ko01002 - - - Creatinase_N,Creatinase_N_2,Peptidase_M24,Peptidase_M24_C k59_1123821_1 702113.PP1Y_AT18131 1.29e-169 487.0 COG2224@1|root,COG2224@2|Bacteria,1MWIF@1224|Proteobacteria,2TU0Q@28211|Alphaproteobacteria,2K0CD@204457|Sphingomonadales 204457|Sphingomonadales C Isocitrate lyase aceA - 4.1.3.1 ko:K01637 ko00630,ko01100,ko01110,ko01120,ko01200,map00630,map01100,map01110,map01120,map01200 M00012 R00479 RC00311,RC00313 ko00000,ko00001,ko00002,ko01000 - - - ICL k59_1462863_1 1046724.KB889829_gene3046 3.23e-08 61.6 COG0489@1|root,COG0489@2|Bacteria,1MU7R@1224|Proteobacteria,1RMJF@1236|Gammaproteobacteria,4647M@72275|Alteromonadaceae 1236|Gammaproteobacteria D Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP - - - - - - - - - - - - DUF971,ParA k59_164985_1 190486.XAC2111 5.45e-66 228.0 COG1530@1|root,COG1530@2|Bacteria,1MV65@1224|Proteobacteria,1RMDS@1236|Gammaproteobacteria,1X37S@135614|Xanthomonadales 135614|Xanthomonadales J Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs rne - 3.1.26.12 ko:K08300 ko03018,map03018 M00394 - - ko00000,ko00001,ko00002,ko01000,ko03009,ko03019 - - - RNase_E_G,S1 k59_501010_1 272952.HpaP800032 1.03e-41 157.0 COG0265@1|root,KOG1421@2759|Eukaryota,3QEFQ@4776|Peronosporales 4776|Peronosporales O PDZ-like domain - - - - - - - - - - - - PDZ_1,PDZ_2,Trypsin_2 k59_620292_1 765913.ThidrDRAFT_0469 8.69e-57 196.0 COG3264@1|root,COG3264@2|Bacteria,1MWSA@1224|Proteobacteria,1RMYY@1236|Gammaproteobacteria,1X08T@135613|Chromatiales 135613|Chromatiales M Mechanosensitive ion channel - - - - - - - - - - - - MS_channel k59_1182623_1 105559.Nwat_0471 7.02e-17 84.0 COG3225@1|root,COG3225@2|Bacteria,1MUXW@1224|Proteobacteria,1RP5U@1236|Gammaproteobacteria,1WX3X@135613|Chromatiales 135613|Chromatiales N PFAM ABC-type uncharacterised transport system - - - - - - - - - - - - ABC_transp_aux k59_1799167_1 316407.1736522 3.68e-128 379.0 COG0018@1|root,COG0018@2|Bacteria,1MU4J@1224|Proteobacteria,1RPRC@1236|Gammaproteobacteria,3XNTV@561|Escherichia 1236|Gammaproteobacteria J arginyl-tRNA aminoacylation argS GO:0003674,GO:0003824,GO:0004812,GO:0004814,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006420,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.19 ko:K01887 ko00970,map00970 M00359,M00360 R03646 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - iECABU_c1320.ECABU_c21380,iECNA114_1301.ECNA114_1940,iECSE_1348.ECSE_2111,iECSF_1327.ECSF_1736,iEcolC_1368.EcolC_1756,iJN746.PP_5089,iLF82_1304.LF82_0128,iNRG857_1313.NRG857_09405,iUMNK88_1353.UMNK88_2348,ic_1306.c2291 Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d k59_445933_1 1444309.JAQG01000157_gene3287 3.92e-22 97.4 COG1131@1|root,COG1131@2|Bacteria,1TRTU@1239|Firmicutes,4HDX9@91061|Bacilli,26VPB@186822|Paenibacillaceae 91061|Bacilli V ATPases associated with a variety of cellular activities - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran,DUF4162 k59_55981_1 199310.c4364 3.89e-83 261.0 COG2194@1|root,COG2194@2|Bacteria,1MWS7@1224|Proteobacteria,1RMNG@1236|Gammaproteobacteria,3XPCS@561|Escherichia 1236|Gammaproteobacteria S Catalyzes the addition of a phosphoethanolamine (pEtN) moiety to the outer 3-deoxy-D-manno-octulosonic acid (Kdo) residue of a Kdo(2)-lipid A. Phosphatidylethanolamines with one unsaturated acyl group functions as pEtN donors and the reaction releases diacylglycerol eptB GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0005976,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0008654,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016740,GO:0016772,GO:0016780,GO:0019637,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0043838,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044464,GO:0046401,GO:0046467,GO:0046493,GO:0071704,GO:0071944,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 2.7.8.42,2.7.8.43 ko:K03760,ko:K12975,ko:K19353 ko00540,ko01503,map00540,map01503 M00722,M00723 R11204,R11205,R11555,R11556,R11557 RC00002,RC00017,RC00428 ko00000,ko00001,ko00002,ko01000,ko01005 - - iSSON_1240.SSON_3844 DUF1705,Sulfatase k59_1239658_1 1121382.JQKG01000017_gene1815 4.33e-05 50.1 COG0596@1|root,COG0596@2|Bacteria 2|Bacteria S hydrolase activity, acting on ester bonds - - - - - - - - - - - - Abhydrolase_1,Abhydrolase_6 k59_955220_1 398579.Spea_2121 3.02e-08 55.5 COG4638@1|root,COG4638@2|Bacteria,1MWU3@1224|Proteobacteria,1RRQS@1236|Gammaproteobacteria,2QDK7@267890|Shewanellaceae 1236|Gammaproteobacteria P PFAM Rieske 2Fe-2S domain protein - - 1.14.13.142 ko:K15982 ko00984,ko01100,ko01120,map00984,map01100,map01120 - R09860 RC02691 ko00000,ko00001,ko01000 - - - Rieske k59_117322_3 1122137.AQXF01000002_gene450 3.08e-152 434.0 COG3185@1|root,COG3185@2|Bacteria,1MUVZ@1224|Proteobacteria,2TRCC@28211|Alphaproteobacteria 28211|Alphaproteobacteria E 4-hydroxyphenylpyruvate dioxygenase hppD GO:0001897,GO:0001906,GO:0001907,GO:0003674,GO:0003824,GO:0003868,GO:0006082,GO:0006520,GO:0006570,GO:0006572,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009072,GO:0009074,GO:0009987,GO:0016054,GO:0016491,GO:0016701,GO:0016702,GO:0019439,GO:0019752,GO:0019835,GO:0019836,GO:0031640,GO:0035821,GO:0043436,GO:0044003,GO:0044004,GO:0044179,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044364,GO:0044403,GO:0044419,GO:0044764,GO:0046395,GO:0051213,GO:0051701,GO:0051704,GO:0051715,GO:0051801,GO:0051817,GO:0051818,GO:0051883,GO:0052331,GO:0055114,GO:0071704,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 1.13.11.27 ko:K00457 ko00130,ko00350,ko00360,ko01100,map00130,map00350,map00360,map01100 M00044 R01372,R02521 RC00505,RC00738 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Glyoxalase,Glyoxalase_5 k59_1359913_1 288000.BBta_p0171 7.71e-106 315.0 COG0309@1|root,COG0309@2|Bacteria,1MVCC@1224|Proteobacteria,2TQSJ@28211|Alphaproteobacteria,3JRGA@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria O hydrogenase expression formation protein - - - ko:K04655 - - - - ko00000 - - - AIRS,AIRS_C k59_173754_1 1122137.AQXF01000001_gene2765 1.06e-97 292.0 COG0115@1|root,COG0115@2|Bacteria,1MVAT@1224|Proteobacteria,2TR7R@28211|Alphaproteobacteria 28211|Alphaproteobacteria EH branched-chain amino acid aminotransferase 4-amino-4-deoxychorismate lyase dat GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006520,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009056,GO:0009058,GO:0009063,GO:0009987,GO:0016053,GO:0016054,GO:0016740,GO:0016769,GO:0019478,GO:0019752,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044281,GO:0044282,GO:0044283,GO:0046394,GO:0046395,GO:0046416,GO:0046437,GO:0047810,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1901607 2.6.1.21 ko:K00824 ko00310,ko00330,ko00360,ko00472,ko00473,ko01100,map00310,map00330,map00360,map00472,map00473,map01100 - R01148,R01582,R02459,R02851,R02924,R05053 RC00006,RC00008,RC00025 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_4 k59_173754_2 1121101.HMPREF1532_01255 4.99e-44 152.0 COG1262@1|root,COG1262@2|Bacteria,4PA78@976|Bacteroidetes,2FYVU@200643|Bacteroidia,4AUDG@815|Bacteroidaceae 976|Bacteroidetes S TIR domain - - - - - - - - - - - - TIR_2 k59_4095_1 1415166.NONO_c48990 3.55e-08 54.3 COG0561@1|root,COG0637@1|root,COG1554@1|root,COG0561@2|Bacteria,COG0637@2|Bacteria,COG1554@2|Bacteria,2GKEV@201174|Actinobacteria,4FU49@85025|Nocardiaceae 201174|Actinobacteria G Glycosyl hydrolase family 65, C-terminal domain otsB1 GO:0003674,GO:0003824,GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0016787,GO:0030312,GO:0044464,GO:0071944 3.1.3.12,3.2.1.28 ko:K01087,ko:K01194 ko00500,ko01100,map00500,map01100 - R00010,R02778 RC00017,RC00049 ko00000,ko00001,ko00537,ko01000 - GH37 - Glyco_hydro_65C,Glyco_hydro_65N,Glyco_hydro_65m,HAD_2,Hydrolase,Trehalose_PPase k59_4095_2 522306.CAP2UW1_0145 5.28e-23 97.1 COG2200@1|root,COG2200@2|Bacteria 2|Bacteria T EAL domain - - - - - - - - - - - - EAL,GGDEF,PAS_4,PAS_9,PTS_EIIC k59_738845_1 305900.GV64_01270 9.43e-18 84.3 COG3038@1|root,COG3038@2|Bacteria,1MZ7X@1224|Proteobacteria,1S6Y7@1236|Gammaproteobacteria,1XKH3@135619|Oceanospirillales 135619|Oceanospirillales C Prokaryotic cytochrome b561 - - - ko:K12262 - - - - ko00000 - - - Ni_hydr_CYTB k59_512375_1 1215092.PA6_008_01000 0.000711 44.3 COG3431@1|root,COG3431@2|Bacteria,1N6PE@1224|Proteobacteria,1S9EB@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Sensors of blue-light using FAD - - - - - - - - - - - - BLUF k59_512375_2 1123389.ATXJ01000002_gene1490 3.3e-52 182.0 COG1364@1|root,COG1364@2|Bacteria,1WJ29@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus E Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate argJ GO:0003674,GO:0003824,GO:0004042,GO:0004358,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006592,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.3.1.1,2.3.1.35 ko:K00620 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028 R00259,R02282 RC00004,RC00064 ko00000,ko00001,ko00002,ko01000 - - - ArgJ k59_286819_1 393283.XP_007830329.1 1.06e-11 70.1 KOG2504@1|root,KOG2504@2759|Eukaryota,38GDS@33154|Opisthokonta,3NYSR@4751|Fungi,3QKF3@4890|Ascomycota,216MH@147550|Sordariomycetes 4751|Fungi G Major facilitator superfamily transporter - - - - - - - - - - - - MFS_1 k59_851587_1 316407.85676453 3.52e-129 383.0 COG3276@1|root,COG3276@2|Bacteria,1MWXH@1224|Proteobacteria,1RQJI@1236|Gammaproteobacteria,3XNXT@561|Escherichia 1236|Gammaproteobacteria J Translation factor necessary for the incorporation of selenocysteine into proteins. It probably replaces EF-Tu for the insertion of selenocysteine directed by the UGA codon. SelB binds GTP and GDP selB GO:0000049,GO:0000166,GO:0001514,GO:0001882,GO:0001883,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006412,GO:0006414,GO:0006417,GO:0006451,GO:0006518,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009069,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010608,GO:0016259,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019003,GO:0019222,GO:0019538,GO:0019752,GO:0031323,GO:0031326,GO:0032268,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034248,GO:0034641,GO:0034645,GO:0035368,GO:0035639,GO:0036094,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051246,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:2000112 - ko:K03833 - - - - ko00000,ko03012 - - - GTP_EFTU,GTP_EFTU_D2,SelB-wing_2,SelB-wing_3 k59_569039_1 987059.RBXJA2T_12837 5.69e-43 162.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2VHFI@28216|Betaproteobacteria,1KJ1H@119065|unclassified Burkholderiales 28216|Betaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family mdtC3 - - ko:K03296 - - - - ko00000 2.A.6.2 - - ACR_tran k59_455982_1 857087.Metme_0969 7.8e-117 343.0 COG1409@1|root,COG1409@2|Bacteria,1MUQJ@1224|Proteobacteria,1S12Q@1236|Gammaproteobacteria,1XEF7@135618|Methylococcales 135618|Methylococcales S Calcineurin-like phosphoesterase superfamily domain - - - - - - - - - - - - Metallophos k59_117344_1 1265505.ATUG01000001_gene3890 1.18e-23 101.0 COG0223@1|root,COG0223@2|Bacteria,1MU4Q@1224|Proteobacteria,42M3E@68525|delta/epsilon subdivisions,2WKMK@28221|Deltaproteobacteria,2MI0Y@213118|Desulfobacterales 28221|Deltaproteobacteria J Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus fmt GO:0003674,GO:0003824,GO:0004479,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006413,GO:0006464,GO:0006518,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016741,GO:0016742,GO:0019538,GO:0019988,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036211,GO:0043043,GO:0043170,GO:0043412,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0046483,GO:0071704,GO:0071951,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 2.1.2.9 ko:K00604 ko00670,ko00970,map00670,map00970 - R03940 RC00026,RC00165 ko00000,ko00001,ko01000 - - - Formyl_trans_C,Formyl_trans_N k59_795123_1 195522.BD01_1529 1.27e-18 85.1 COG1522@1|root,arCOG01580@2157|Archaea,2XZQ1@28890|Euryarchaeota,245GQ@183968|Thermococci 183968|Thermococci K helix_turn_helix ASNC type - - - ko:K03718 - - - - ko00000,ko03000 - - - AsnC_trans_reg,HTH_24,HTH_AsnC-type k59_1529433_1 1122599.AUGR01000008_gene2560 1.46e-28 119.0 COG1452@1|root,COG1452@2|Bacteria,1MUJC@1224|Proteobacteria,1RQEX@1236|Gammaproteobacteria,1XHEA@135619|Oceanospirillales 135619|Oceanospirillales M Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane lptD - - ko:K04744 - - - - ko00000,ko02000 1.B.42.1 - - OstA,OstA_C k59_681857_1 1297570.MESS4_160039 1.09e-11 65.1 COG1793@1|root,COG3285@1|root,COG1793@2|Bacteria,COG3285@2|Bacteria,1MVWY@1224|Proteobacteria,2TRSZ@28211|Alphaproteobacteria,43IJ1@69277|Phyllobacteriaceae 28211|Alphaproteobacteria L DNA ligase - - 6.5.1.1 ko:K01971 ko03450,map03450 - R00381 RC00005 ko00000,ko00001,ko01000,ko03400 - - - DNA_ligase_A_C,DNA_ligase_A_M,LigD_N k59_681857_2 404589.Anae109_0938 9.32e-66 210.0 COG1273@1|root,COG1273@2|Bacteria,1N4UX@1224|Proteobacteria,42RD5@68525|delta/epsilon subdivisions,2WMZ1@28221|Deltaproteobacteria,2YWME@29|Myxococcales 28221|Deltaproteobacteria L With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD ku - - ko:K10979 ko03450,map03450 - - - ko00000,ko00001,ko03400 - - - Ku k59_851599_2 477184.KYC_05159 2.61e-92 278.0 COG0745@1|root,COG0745@2|Bacteria,1MU67@1224|Proteobacteria,2VHHB@28216|Betaproteobacteria,3T2GH@506|Alcaligenaceae 28216|Betaproteobacteria K COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain - - - ko:K02483,ko:K07665 ko02020,map02020 M00452,M00745 - - ko00000,ko00001,ko00002,ko01504,ko02022 - - - Response_reg,Trans_reg_C k59_1246990_1 1449049.JONW01000005_gene1031 0.000561 50.1 COG3866@1|root,COG3866@2|Bacteria,1MUT3@1224|Proteobacteria,2U57M@28211|Alphaproteobacteria,2KI40@204458|Caulobacterales 204458|Caulobacterales G Pectate lyase - - - - - - - - - - - - - k59_512413_1 1411123.JQNH01000001_gene2843 2.37e-72 228.0 COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,2TSGZ@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Transposase (IS116 IS110 IS902 family) - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_286849_2 1266925.JHVX01000015_gene226 6.38e-44 149.0 COG0299@1|root,COG0299@2|Bacteria,1MWN1@1224|Proteobacteria,2VJG8@28216|Betaproteobacteria,371SB@32003|Nitrosomonadales 28216|Betaproteobacteria F Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate purN - 2.1.2.2 ko:K11175 ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130 M00048 R04325,R04326 RC00026,RC00197,RC01128 ko00000,ko00001,ko00002,ko01000 - - - Formyl_trans_N k59_625440_1 1232683.ADIMK_3373 4.66e-26 107.0 COG1560@1|root,COG1560@2|Bacteria,1Q41N@1224|Proteobacteria,1RRRE@1236|Gammaproteobacteria,466K6@72275|Alteromonadaceae 1236|Gammaproteobacteria M Bacterial lipid A biosynthesis acyltransferase htrB - 2.3.1.241 ko:K02517 ko00540,ko01100,map00540,map01100 M00060 R05146 RC00037,RC00039 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Lip_A_acyltrans k59_795134_1 698761.RTCIAT899_CH12475 9.74e-100 298.0 COG0667@1|root,COG0667@2|Bacteria,1MVEH@1224|Proteobacteria,2TRHS@28211|Alphaproteobacteria,4B83N@82115|Rhizobiaceae 28211|Alphaproteobacteria C Aldo/keto reductase family - - 1.1.1.65 ko:K05275 ko00750,ko01100,ko01120,map00750,map01100,map01120 - R01708 RC00116 ko00000,ko00001,ko01000 - - - Aldo_ket_red k59_964490_1 368408.Tpen_1350 1.21e-41 153.0 COG1473@1|root,arCOG01108@2157|Archaea,2XRII@28889|Crenarchaeota 28889|Crenarchaeota E carboxypeptidase activity - - - ko:K12941,ko:K13048 - - - - ko00000,ko01000,ko01002 - - - M20_dimer,Peptidase_M20 k59_569091_1 324602.Caur_2783 2.72e-45 159.0 COG0601@1|root,COG0601@2|Bacteria,2G662@200795|Chloroflexi 200795|Chloroflexi P PFAM binding-protein-dependent transport systems inner membrane component - - - ko:K02033 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1 k59_117369_1 667632.KB890168_gene5207 5.74e-56 189.0 COG1680@1|root,COG1680@2|Bacteria,1MXHB@1224|Proteobacteria,2VXTZ@28216|Betaproteobacteria,1K34C@119060|Burkholderiaceae 28216|Betaproteobacteria V Beta-lactamase - - - - - - - - - - - - Beta-lactamase k59_229954_1 666685.R2APBS1_3248 2.26e-31 125.0 COG0654@1|root,COG0654@2|Bacteria,1MU6I@1224|Proteobacteria,1RND5@1236|Gammaproteobacteria,1X3DS@135614|Xanthomonadales 135614|Xanthomonadales CH Catalyzes the formation of 2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinol from 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol visC - - ko:K03184,ko:K18800 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00117 R04987,R06146,R08768,R08775 RC00046,RC01254 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_3,SE k59_1021350_1 247633.GP2143_05015 1.72e-83 264.0 COG1022@1|root,COG1022@2|Bacteria,1MU4D@1224|Proteobacteria,1RPNE@1236|Gammaproteobacteria,1J4V9@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria I COG1022 Long-chain acyl-CoA synthetases (AMP-forming) - - - - - - - - - - - - AMP-binding,Haem_oxygenas_2 k59_60887_1 1116472.MGMO_83c00160 6.12e-99 303.0 COG0516@1|root,COG0517@1|root,COG0516@2|Bacteria,COG0517@2|Bacteria,1MUJM@1224|Proteobacteria,1RMT8@1236|Gammaproteobacteria,1XESH@135618|Methylococcales 135618|Methylococcales F Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth guaB - 1.1.1.205 ko:K00088 ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 M00050 R01130,R08240 RC00143,RC02207 ko00000,ko00001,ko00002,ko01000,ko04147 - - - CBS,IMPDH k59_512429_1 1122137.AQXF01000004_gene1714 1.16e-132 400.0 COG1770@1|root,COG1770@2|Bacteria,1MUED@1224|Proteobacteria,2TTR0@28211|Alphaproteobacteria 28211|Alphaproteobacteria E peptidase S9A, prolyl oligopeptidase domain protein beta-propeller ptrB - 3.4.21.83 ko:K01354 ko05142,ko05143,map05142,map05143 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_S9,Peptidase_S9_N k59_795141_1 555793.WSK_3150 5.11e-71 229.0 COG4166@1|root,COG4166@2|Bacteria,1P91R@1224|Proteobacteria,2TT6P@28211|Alphaproteobacteria,2K08U@204457|Sphingomonadales 204457|Sphingomonadales E ABC-type oligopeptide transport system, periplasmic component - - - ko:K02035,ko:K15580 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00239,M00439 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 - - SBP_bac_5 k59_1303566_2 314287.GB2207_11178 1.02e-48 166.0 28KE4@1|root,2ZA0D@2|Bacteria,1MXZT@1224|Proteobacteria,1RYV4@1236|Gammaproteobacteria,1J6JN@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_512432_1 443143.GM18_0861 6.66e-66 228.0 COG1196@1|root,COG1196@2|Bacteria,1MUAQ@1224|Proteobacteria,42MN9@68525|delta/epsilon subdivisions,2WJZF@28221|Deltaproteobacteria,43T01@69541|Desulfuromonadales 28221|Deltaproteobacteria D Required for chromosome condensation and partitioning smc - - ko:K03529 - - - - ko00000,ko03036 - - - SMC_N,SMC_hinge k59_512432_2 416348.Hlac_0078 1.32e-71 238.0 COG1132@1|root,arCOG02841@2157|Archaea,2XSW0@28890|Euryarchaeota,23SNM@183963|Halobacteria 183963|Halobacteria P COG1132 ABC-type multidrug transport system, ATPase and permease components - - - ko:K06147 - - - - ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran k59_1416256_1 685778.AORL01000004_gene3562 4.96e-11 63.2 COG0427@1|root,COG0427@2|Bacteria,1MUGE@1224|Proteobacteria,2TQYS@28211|Alphaproteobacteria,2K0X0@204457|Sphingomonadales 204457|Sphingomonadales C acetyl-CoA hydrolase - - 2.8.3.18 ko:K18118 ko00020,ko00620,ko00650,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00650,map01100,map01110,map01120,map01130,map01200 M00009,M00011 R10343 RC00012,RC00014 ko00000,ko00001,ko00002,ko01000 - - - AcetylCoA_hyd_C,AcetylCoA_hydro k59_1359975_1 1209072.ALBT01000031_gene1847 1.51e-99 311.0 COG0187@1|root,COG0187@2|Bacteria,1MVKT@1224|Proteobacteria,1RNB2@1236|Gammaproteobacteria,1FGV1@10|Cellvibrio 1236|Gammaproteobacteria L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrB GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003916,GO:0003918,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006265,GO:0006351,GO:0006725,GO:0006807,GO:0006996,GO:0007059,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009295,GO:0009330,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017076,GO:0017111,GO:0018130,GO:0019438,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032774,GO:0032991,GO:0034335,GO:0034641,GO:0034645,GO:0034654,GO:0035639,GO:0036094,GO:0042221,GO:0042493,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051276,GO:0061505,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0097367,GO:0097659,GO:0140097,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901576 5.99.1.3 ko:K02470 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim k59_286884_1 305900.GV64_02365 1.4e-43 153.0 COG0451@1|root,COG0451@2|Bacteria,1MWVJ@1224|Proteobacteria,1RNDT@1236|Gammaproteobacteria,1XJAJ@135619|Oceanospirillales 135619|Oceanospirillales GM epimerase - - - - - - - - - - - - Epimerase,NAD_binding_10,RmlD_sub_bind k59_1416268_1 1298593.TOL_1767 9.18e-79 251.0 COG0644@1|root,COG2440@1|root,COG0644@2|Bacteria,COG2440@2|Bacteria,1MVU6@1224|Proteobacteria,1RNY5@1236|Gammaproteobacteria,1XHVH@135619|Oceanospirillales 135619|Oceanospirillales C Electron transfer flavoprotein-ubiquinone oxidoreductase etf - 1.5.5.1 ko:K00311 - - - - ko00000,ko01000 - - - ETF_QO,FAD_binding_2,NAD_binding_8 k59_1190615_1 1279038.KB907357_gene2033 1.19e-32 122.0 COG1073@1|root,COG1073@2|Bacteria,1MX88@1224|Proteobacteria,2TSRE@28211|Alphaproteobacteria,2JQD5@204441|Rhodospirillales 204441|Rhodospirillales S hydrolases or acyltransferases (alpha beta hydrolase superfamily) - - - - - - - - - - - - Abhydrolase_1,Abhydrolase_6,Hydrolase_4 k59_569118_1 944435.AXAJ01000006_gene3717 1.74e-16 80.5 COG4221@1|root,COG4221@2|Bacteria,1QVS5@1224|Proteobacteria,2WETH@28216|Betaproteobacteria,1KHVB@119060|Burkholderiaceae 28216|Betaproteobacteria S Belongs to the short-chain dehydrogenases reductases (SDR) family - - - - - - - - - - - - adh_short k59_1359982_1 1448139.AI20_02540 6.47e-52 185.0 COG0616@1|root,COG0616@2|Bacteria,1MUXE@1224|Proteobacteria,1RNYW@1236|Gammaproteobacteria,1Y3JV@135624|Aeromonadales 135624|Aeromonadales OU signal peptide peptidase sppA - - ko:K04773 - - - - ko00000,ko01000,ko01002 - - - Peptidase_S49 k59_1529493_1 247634.GPB2148_3115 1.57e-180 531.0 COG0653@1|root,COG0653@2|Bacteria,1MUJZ@1224|Proteobacteria,1RM9M@1236|Gammaproteobacteria,1J56C@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane secA GO:0000166,GO:0002790,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006457,GO:0006605,GO:0006810,GO:0006886,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0009306,GO:0009987,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032940,GO:0032991,GO:0033036,GO:0033220,GO:0034613,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042802,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0046903,GO:0046907,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0061077,GO:0065002,GO:0070727,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680 - ko:K03070 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4 - - SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW k59_569125_1 83406.HDN1F_15880 8.79e-89 280.0 COG0326@1|root,COG0326@2|Bacteria,1MUUE@1224|Proteobacteria,1RNWD@1236|Gammaproteobacteria,1J4YG@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O Molecular chaperone. Has ATPase activity htpG GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006950,GO:0006974,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0033554,GO:0042623,GO:0042802,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716 - ko:K04079 ko04141,ko04151,ko04217,ko04612,ko04621,ko04626,ko04657,ko04659,ko04914,ko04915,ko05200,ko05215,ko05418,map04141,map04151,map04217,map04612,map04621,map04626,map04657,map04659,map04914,map04915,map05200,map05215,map05418 - - - ko00000,ko00001,ko01009,ko03029,ko03051,ko03110,ko04131,ko04147 - - - HATPase_c,HATPase_c_3,HSP90 k59_1077342_1 1370120.AUWR01000088_gene2373 1.81e-82 259.0 COG1012@1|root,COG1012@2|Bacteria,2GIWZ@201174|Actinobacteria,233QF@1762|Mycobacteriaceae 201174|Actinobacteria C Aldehyde dehydrogenase - - 1.2.1.3 ko:K00128 ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130 M00135 R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146 RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_1077342_2 1437824.BN940_13056 1.08e-18 85.5 COG0160@1|root,COG0160@2|Bacteria,1MWY6@1224|Proteobacteria,2VJIT@28216|Betaproteobacteria,3T1HM@506|Alcaligenaceae 28216|Betaproteobacteria H Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family gabT - 2.6.1.19,2.6.1.22 ko:K00823,ko:K07250 ko00250,ko00280,ko00410,ko00640,ko00650,ko01100,ko01120,map00250,map00280,map00410,map00640,map00650,map01100,map01120 M00027 R00908,R01648,R04188 RC00006,RC00062,RC00160 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 k59_964533_1 203122.Sde_1650 7.38e-08 59.3 COG5297@1|root,COG5297@2|Bacteria,1NRKN@1224|Proteobacteria,1S094@1236|Gammaproteobacteria,46A47@72275|Alteromonadaceae 1236|Gammaproteobacteria G CBD_II rgl11A - - - - - - - - - - - CBM_2 k59_1303577_1 1229909.NSED_08005 5.5e-18 78.6 COG0589@1|root,arCOG02053@2157|Archaea,41TB2@651137|Thaumarchaeota 651137|Thaumarchaeota T COG0589 Universal stress protein UspA and related nucleotide-binding proteins - - - - - - - - - - - - Usp k59_1303577_2 304371.MCP_0299 3.86e-17 80.1 COG0517@1|root,arCOG00606@2157|Archaea,2XX11@28890|Euryarchaeota,2N9VZ@224756|Methanomicrobia 224756|Methanomicrobia S PFAM CBS domain containing protein - - - - - - - - - - - - CBS k59_1416279_1 1255043.TVNIR_2815 6.43e-23 92.8 COG0801@1|root,COG0801@2|Bacteria,1MZH8@1224|Proteobacteria,1S63J@1236|Gammaproteobacteria,1WYQM@135613|Chromatiales 135613|Chromatiales H PFAM 7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK - - 2.7.6.3 ko:K00950 ko00790,ko01100,map00790,map01100 M00126,M00841 R03503 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - HPPK k59_1416279_2 377629.TERTU_0568 2.13e-30 114.0 COG1428@1|root,COG1428@2|Bacteria,1RC50@1224|Proteobacteria,1RRXT@1236|Gammaproteobacteria,2PMXK@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria F Deoxynucleoside kinase dgk - - - - - - - - - - - dNK k59_1698893_1 1454004.AW11_02855 1.43e-126 374.0 COG0651@1|root,COG0651@2|Bacteria,1QU5Z@1224|Proteobacteria,2VPQP@28216|Betaproteobacteria 28216|Betaproteobacteria CP Proton-conducting membrane transporter - - - - - - - - - - - - Proton_antipo_M,Proton_antipo_N k59_1360002_1 1122212.AULO01000014_gene1193 1.97e-59 205.0 COG1200@1|root,COG1200@2|Bacteria,1MWN2@1224|Proteobacteria,1RMMQ@1236|Gammaproteobacteria,1XIN2@135619|Oceanospirillales 135619|Oceanospirillales L Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) recG - 3.6.4.12 ko:K03655 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,Helicase_C,RecG_wedge k59_1755336_1 477974.Daud_1762 2.8e-67 218.0 COG1157@1|root,COG1157@2|Bacteria,1TP0R@1239|Firmicutes,25E6B@186801|Clostridia,26126@186807|Peptococcaceae 186801|Clostridia NU TIGRFAM ATPase, FliI YscN family fliI - 3.6.3.14 ko:K02412,ko:K03224 ko02040,ko03070,map02040,map03070 M00332,M00542,M00660 - - ko00000,ko00001,ko00002,ko01000,ko02035,ko02044 3.A.6.1,3.A.6.2,3.A.6.3 - - ATP-synt_ab,ATP-synt_ab_N k59_964547_1 926550.CLDAP_11170 5.37e-06 48.5 COG0154@1|root,COG0154@2|Bacteria,2G5T0@200795|Chloroflexi 200795|Chloroflexi J Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) gatA - 6.3.5.6,6.3.5.7 ko:K02433 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - Amidase k59_964547_2 1166948.JPZL01000001_gene2472 1.1e-29 108.0 COG0721@1|root,COG0721@2|Bacteria,1MZQP@1224|Proteobacteria,1S8VY@1236|Gammaproteobacteria,1XMBW@135619|Oceanospirillales 135619|Oceanospirillales J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) gatC - 6.3.5.6,6.3.5.7 ko:K02435 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - Glu-tRNAGln k59_569149_1 1122194.AUHU01000005_gene946 3.16e-82 265.0 COG0072@1|root,COG0072@2|Bacteria,1MWKS@1224|Proteobacteria,1RMIH@1236|Gammaproteobacteria,464S9@72275|Alteromonadaceae 1236|Gammaproteobacteria J Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily pheT GO:0003674,GO:0003824,GO:0004812,GO:0004826,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0042802,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494 6.1.1.20 ko:K01890 ko00970,map00970 M00359,M00360 R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iG2583_1286.G2583_2160,iPC815.YPO2428 B3_4,B5,FDX-ACB,tRNA_bind k59_1134044_1 519989.ECTPHS_14046 2.71e-28 111.0 COG2801@1|root,COG2801@2|Bacteria,1R6TH@1224|Proteobacteria,1RRWS@1236|Gammaproteobacteria,1X2I8@135613|Chromatiales 135613|Chromatiales L Mu transposase, C-terminal - - - - - - - - - - - - HTH_32,Mu-transpos_C,rve k59_1134044_2 631362.Thi970DRAFT_03296 1.62e-74 229.0 COG3267@1|root,COG3267@2|Bacteria,1REWJ@1224|Proteobacteria,1S518@1236|Gammaproteobacteria,1X0QD@135613|Chromatiales 1236|Gammaproteobacteria U Type II secretory pathway, component ExeA - - - - - - - - - - - - AAA_22 k59_286909_1 748247.AZKH_2874 2.35e-114 341.0 COG2896@1|root,COG2896@2|Bacteria,1MW3W@1224|Proteobacteria,2VHW4@28216|Betaproteobacteria,2KURW@206389|Rhodocyclales 206389|Rhodocyclales H Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate moaA - 4.1.99.22 ko:K03639 ko00790,ko01100,ko04122,map00790,map01100,map04122 - R09394 RC03420 ko00000,ko00001,ko01000 - - - Fer4_12,Fer4_14,Mob_synth_C,Radical_SAM k59_286909_2 112098.XP_008620313.1 3.17e-36 129.0 COG2896@1|root,KOG2876@2759|Eukaryota 2759|Eukaryota H cyclic pyranopterin monophosphate synthase activity - GO:0006732,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0018130,GO:0019538,GO:0019637,GO:0019720,GO:0043170,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0046483,GO:0051186,GO:0051188,GO:0051189,GO:0071704,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.99.22,4.6.1.17 ko:K03639,ko:K20967 ko00790,ko01100,ko04122,map00790,map01100,map04122 - R09394,R11372 RC03420,RC03425 ko00000,ko00001,ko01000 - - - Fer4_12,MoaC,Mob_synth_C,Radical_SAM k59_1360017_1 314345.SPV1_05442 4.38e-66 218.0 COG2307@1|root,COG2307@2|Bacteria,1MVZK@1224|Proteobacteria 1224|Proteobacteria S protein conserved in bacteria - - - - - - - - - - - - Alpha-E k59_1529541_1 1535422.ND16A_1895 6.49e-67 207.0 COG1803@1|root,COG1803@2|Bacteria,1RD3D@1224|Proteobacteria,1S3XN@1236|Gammaproteobacteria,2Q726@267889|Colwelliaceae 1236|Gammaproteobacteria G MGS-like domain mgsA GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0008150,GO:0008152,GO:0008929,GO:0009058,GO:0009438,GO:0009987,GO:0016829,GO:0016835,GO:0016838,GO:0019242,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046184,GO:0071704,GO:1901576 4.2.3.3 ko:K01734 ko00640,ko01120,map00640,map01120 - R01016 RC00424 ko00000,ko00001,ko01000 - - iECUMN_1333.ECUMN_1153,iYL1228.KPN_00992 MGS k59_1585831_1 1122137.AQXF01000001_gene2862 2.34e-63 197.0 COG0745@1|root,COG0745@2|Bacteria,1MZ8W@1224|Proteobacteria,2U9PK@28211|Alphaproteobacteria 28211|Alphaproteobacteria T Response regulator receiver MA20_20475 - - - - - - - - - - - Response_reg k59_1585831_2 1280941.HY2_14570 8.71e-36 133.0 COG0019@1|root,COG0019@2|Bacteria,1MUA6@1224|Proteobacteria,2TQPB@28211|Alphaproteobacteria,43WZD@69657|Hyphomonadaceae 28211|Alphaproteobacteria E Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine lysA GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008836,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016829,GO:0016830,GO:0016831,GO:0019752,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046451,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.2.4,4.1.1.20 ko:K01586,ko:K12526 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00017,M00018,M00525,M00526,M00527 R00451,R00480 RC00002,RC00043,RC00299 ko00000,ko00001,ko00002,ko01000 - - - Orn_Arg_deC_N,Orn_DAP_Arg_deC k59_286921_1 1415778.JQMM01000001_gene1614 1.76e-40 144.0 COG0133@1|root,COG0133@2|Bacteria,1MUS8@1224|Proteobacteria,1RP4D@1236|Gammaproteobacteria,1J5D5@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine trpB GO:0000162,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 4.2.1.20 ko:K01696 ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230 M00023 R00674,R02340,R02722 RC00209,RC00210,RC00700,RC00701,RC02868 ko00000,ko00001,ko00002,ko01000 - - - PALP k59_286921_2 1123279.ATUS01000001_gene945 4.43e-42 145.0 COG0135@1|root,COG0135@2|Bacteria,1RA87@1224|Proteobacteria,1S41P@1236|Gammaproteobacteria,1J637@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Belongs to the TrpF family trpF - 5.3.1.24 ko:K01817 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R03509 RC00945 ko00000,ko00001,ko00002,ko01000 - - - PRAI k59_907950_2 436308.Nmar_0689 2.91e-48 157.0 arCOG08023@1|root,arCOG08023@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - zinc_ribbon_2 k59_343440_1 41431.PCC8801_0299 2.69e-85 257.0 COG1515@1|root,COG1515@2|Bacteria,1G2HF@1117|Cyanobacteria,3KGS5@43988|Cyanothece 1117|Cyanobacteria L DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA nfi - 3.1.21.7 ko:K05982 - - - - ko00000,ko01000,ko03400 - - - Endonuclease_5 k59_1699935_2 69395.JQLZ01000002_gene1251 3.07e-24 102.0 COG0665@1|root,COG0665@2|Bacteria,1MU40@1224|Proteobacteria,2TTKE@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Tryptophan halogenase - - 1.14.19.9 ko:K14266 ko00404,ko01130,map00404,map01130 M00789,M00790 R09570 RC00949 ko00000,ko00001,ko00002,ko01000 - - - Trp_halogenase k59_1586787_1 1178825.ALIH01000004_gene2977 1.7e-90 277.0 COG0501@1|root,COG0501@2|Bacteria,4NESF@976|Bacteroidetes,1HWMY@117743|Flavobacteriia 976|Bacteroidetes O Zn-dependent protease with chaperone function - - 3.4.24.84 ko:K03799,ko:K06013 ko00900,ko01130,map00900,map01130 M00743 R09845 RC00141 ko00000,ko00001,ko00002,ko01000,ko01002,ko04147 - - - Peptidase_M48,Peptidase_M48_N k59_965495_1 1122963.AUHB01000013_gene4621 2.85e-191 544.0 COG0477@1|root,COG2814@2|Bacteria,1MU1I@1224|Proteobacteria,2TVXT@28211|Alphaproteobacteria,36Y42@31993|Methylocystaceae 28211|Alphaproteobacteria EGP Major Facilitator Superfamily - - - ko:K03446 - M00701 - - ko00000,ko00002,ko02000 2.A.1.3 - - MFS_1 k59_1643629_1 1049564.TevJSym_bu00010 7.31e-107 327.0 COG0480@1|root,COG0480@2|Bacteria,1MUCV@1224|Proteobacteria,1RNSZ@1236|Gammaproteobacteria,1J4UF@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome fusA - - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2 k59_1078477_1 305900.GV64_17610 9.35e-43 150.0 COG0372@1|root,COG0372@2|Bacteria,1MUKX@1224|Proteobacteria,1RNDK@1236|Gammaproteobacteria,1XI41@135619|Oceanospirillales 135619|Oceanospirillales C Belongs to the citrate synthase family gltA - 2.3.3.1 ko:K01647 ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00740 R00351 RC00004,RC00067 br01601,ko00000,ko00001,ko00002,ko01000 - - - Citrate_synt k59_62004_1 765911.Thivi_3494 4.07e-106 333.0 COG0525@1|root,COG0525@2|Bacteria,1MV7B@1224|Proteobacteria,1RNEB@1236|Gammaproteobacteria,1WWJI@135613|Chromatiales 135613|Chromatiales J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner valS - 6.1.1.9 ko:K01873 ko00970,map00970 M00359,M00360 R03665 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1 k59_513486_1 1122137.AQXF01000006_gene734 1.03e-38 129.0 COG0483@1|root,COG0483@2|Bacteria,1N7D7@1224|Proteobacteria,2UF6T@28211|Alphaproteobacteria 28211|Alphaproteobacteria G Inositol monophosphatase MA20_05805 - - - - - - - - - - - DUF4170 k59_513486_2 1122137.AQXF01000006_gene733 1.44e-15 73.2 COG2716@1|root,COG2716@2|Bacteria,1RM4T@1224|Proteobacteria,2UBAI@28211|Alphaproteobacteria 28211|Alphaproteobacteria E regulation of RNA biosynthetic process - - - ko:K03567 ko02026,map02026 - - - ko00000,ko00001,ko03000 - - - ACT_6 k59_1599951_2 1232410.KI421416_gene2645 2.72e-18 77.4 2EE6A@1|root,3380W@2|Bacteria,1NCBW@1224|Proteobacteria,42V9R@68525|delta/epsilon subdivisions,2WSI3@28221|Deltaproteobacteria,43VQV@69541|Desulfuromonadales 28221|Deltaproteobacteria - - - - - - - - - - - - - - - k59_1599951_3 997829.HMPREF1121_00873 5.72e-74 231.0 COG0113@1|root,COG0113@2|Bacteria,4NFW6@976|Bacteroidetes,2FPXC@200643|Bacteroidia 976|Bacteroidetes H Belongs to the ALAD family hemB - 4.2.1.24 ko:K01698 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R00036 RC00918,RC01781 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ALAD k59_1487784_1 472759.Nhal_1910 1.83e-71 233.0 COG1132@1|root,COG1132@2|Bacteria,1N1Z8@1224|Proteobacteria,1RPVC@1236|Gammaproteobacteria,1WWAF@135613|Chromatiales 135613|Chromatiales V ABC transporter transmembrane region - - - ko:K06148 - - - - ko00000,ko02000 3.A.1 - - ABC_membrane,ABC_tran k59_1147748_1 104623.Ser39006_04082 4.14e-12 73.6 COG0726@1|root,COG2931@1|root,COG2982@1|root,COG3210@1|root,COG4625@1|root,COG0726@2|Bacteria,COG2931@2|Bacteria,COG2982@2|Bacteria,COG3210@2|Bacteria,COG4625@2|Bacteria,1MU7T@1224|Proteobacteria,1S1HJ@1236|Gammaproteobacteria 1236|Gammaproteobacteria Q COG2931, RTX toxins and related Ca2 -binding proteins - - - - - - - - - - - - Cadherin,Cadherin_3,DUF4214,DUF4347,He_PIG,HemolysinCabind,PATR,VCBS k59_1147750_1 1484460.JSWG01000004_gene2612 5.29e-114 334.0 COG4242@1|root,COG4242@2|Bacteria,4NI55@976|Bacteroidetes,1HZY7@117743|Flavobacteriia 976|Bacteroidetes PQ Belongs to the peptidase S51 family cphB - 3.4.15.6 ko:K13282 - - R09722 RC00064,RC00141 ko00000,ko01000,ko01002 - - - Peptidase_S51 k59_1430206_1 1144307.PMI04_00477 1.02e-52 186.0 COG3250@1|root,COG3250@2|Bacteria,1MVBN@1224|Proteobacteria,2U0KF@28211|Alphaproteobacteria,2K2GK@204457|Sphingomonadales 204457|Sphingomonadales G Belongs to the glycosyl hydrolase 2 family - - 3.2.1.23 ko:K01190 ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100 - R01105,R01678,R03355,R04783,R06114 RC00049,RC00452 ko00000,ko00001,ko01000 - - - DUF4982,Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N,Malectin k59_639686_1 1469607.KK073768_gene4817 2.67e-26 114.0 COG1357@1|root,COG1672@1|root,COG4249@1|root,COG1357@2|Bacteria,COG1672@2|Bacteria,COG4249@2|Bacteria,1G3JV@1117|Cyanobacteria,1HJ0H@1161|Nostocales 1117|Cyanobacteria S Caspase domain - - - - - - - - - - - - AAA_16,GGDEF,Pentapeptide,Peptidase_C14 k59_1487787_1 904294.HMPREF9182_0548 1.29e-47 160.0 COG1136@1|root,COG1136@2|Bacteria,1TPBJ@1239|Firmicutes,4HBMF@91061|Bacilli 91061|Bacilli V ABC transporter, ATP-binding protein salX - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_977657_1 1424334.W822_00780 5.44e-15 78.2 COG2863@1|root,COG2863@2|Bacteria,1RGTS@1224|Proteobacteria,2VSFZ@28216|Betaproteobacteria,3T4AZ@506|Alcaligenaceae 28216|Betaproteobacteria C Cytochrome C oxidase, cbb3-type, subunit III - - - - - - - - - - - - Cytochrom_C,Cytochrome_CBB3 k59_977657_3 745014.OMB55_00006180 1.14e-74 238.0 COG2015@1|root,COG2015@2|Bacteria,1R9IE@1224|Proteobacteria 1224|Proteobacteria Q Alkyl sulfatase and related hydrolases - - - - - - - - - - - - Alkyl_sulf_dimr,Lactamase_B k59_131301_1 1198232.CYCME_0591 2.28e-56 189.0 COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,1RMWA@1236|Gammaproteobacteria,4604E@72273|Thiotrichales 72273|Thiotrichales JKL DEAD-box RNA helicase involved in RNA degradation. Has RNA-dependent ATPase activity and unwinds double-stranded RNA rhlB - 3.6.4.13 ko:K03732 ko03018,map03018 M00394 - - ko00000,ko00001,ko00002,ko01000,ko03019 - - - DEAD,Helicase_C k59_809508_1 67356.KL575606_gene3197 2.66e-48 164.0 COG0411@1|root,COG0411@2|Bacteria,2GMEE@201174|Actinobacteria 201174|Actinobacteria E ABC transporter - - - ko:K01995 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - ABC_tran,BCA_ABC_TP_C k59_809508_2 1123024.AUII01000006_gene4531 1.02e-18 86.7 COG4177@1|root,COG4177@2|Bacteria,2GJB3@201174|Actinobacteria,4E0ZS@85010|Pseudonocardiales 201174|Actinobacteria E Belongs to the binding-protein-dependent transport system permease family livM - - ko:K01998 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - BPD_transp_2 k59_809510_1 935567.JAES01000001_gene2274 8.65e-29 115.0 COG3221@1|root,COG3221@2|Bacteria,1RKVE@1224|Proteobacteria,1S8D7@1236|Gammaproteobacteria,1XCPB@135614|Xanthomonadales 135614|Xanthomonadales P ABC transporter, phosphonate, periplasmic substrate-binding protein - - - ko:K02044 ko02010,map02010 M00223 - - ko00000,ko00001,ko00002,ko02000 3.A.1.9 - - Phosphonate-bd k59_582855_1 1279017.AQYJ01000022_gene2615 4.24e-81 255.0 28MBM@1|root,2ZAQ2@2|Bacteria,1R5V6@1224|Proteobacteria,1S0K0@1236|Gammaproteobacteria,4662R@72275|Alteromonadaceae 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_866466_1 1229909.NSED_05085 1.78e-57 187.0 COG1468@1|root,arCOG00786@2157|Archaea 2157|Archaea L TIGRFAM CRISPR-associated protein Cas4 - - 3.1.12.1 ko:K03466,ko:K07464,ko:K15342,ko:K19465 - - - - ko00000,ko01000,ko02048,ko03029,ko03036,ko03400 3.A.12 - - Cas_Cas4,FtsK_SpoIIIE,PDDEXK_1 k59_1543842_1 452637.Oter_2726 8.58e-47 161.0 COG1560@1|root,COG1560@2|Bacteria 2|Bacteria M Kdo2-lipid A biosynthetic process htrB - 2.3.1.241 ko:K02517 ko00540,ko01100,map00540,map01100 M00060 R05146 RC00037,RC00039 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Lip_A_acyltrans k59_301415_2 436308.Nmar_0395 8.24e-43 144.0 COG1730@1|root,arCOG01341@2157|Archaea,41SSP@651137|Thaumarchaeota 651137|Thaumarchaeota O Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding pfdA - - ko:K04797 - - - - ko00000,ko03110 - - - Prefoldin k59_1260790_2 318424.EU78_15475 1.39e-23 102.0 COG0300@1|root,COG0300@2|Bacteria,2I2NU@201174|Actinobacteria,237U0@1762|Mycobacteriaceae 201174|Actinobacteria S Enoyl-(Acyl carrier protein) reductase - - - - - - - - - - - - adh_short_C2 k59_188139_2 112098.XP_008621646.1 0.00057 43.9 COG0666@1|root,KOG0504@2759|Eukaryota,KOG4177@2759|Eukaryota 2759|Eukaryota I spectrin binding - - - ko:K15503 - - - - ko00000,ko01009,ko03400 - - - Ank,Ank_2,Ank_4,zf-C3HC4_3 k59_1147802_1 404589.Anae109_0478 2.27e-137 407.0 COG0442@1|root,COG0442@2|Bacteria,1MU7E@1224|Proteobacteria,42ME5@68525|delta/epsilon subdivisions,2WKA2@28221|Deltaproteobacteria,2YZII@29|Myxococcales 28221|Deltaproteobacteria J Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS proS - 6.1.1.15 ko:K01881 ko00970,map00970 M00359,M00360 R03661 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,tRNA-synt_2b,tRNA_edit k59_922065_1 123214.PERMA_1697 0.000907 44.3 COG0224@1|root,COG0224@2|Bacteria 2|Bacteria C proton-transporting ATP synthase activity, rotational mechanism atpG_1 - - ko:K02115 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt k59_922065_2 1121479.AUBS01000041_gene658 1.45e-68 226.0 COG0055@1|root,COG0055@2|Bacteria,1N6UZ@1224|Proteobacteria,2TT70@28211|Alphaproteobacteria 28211|Alphaproteobacteria C Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits atpD_2 - 3.6.3.14 ko:K02112 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - - ATP-synt_ab,ATP-synt_ab_N k59_18492_1 1095769.CAHF01000023_gene447 8.82e-76 236.0 COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,2VJ5I@28216|Betaproteobacteria 28216|Betaproteobacteria C acyl-CoA dehydrogenase - - - ko:K11731 ko00281,map00281 - R08089 RC01893 ko00000,ko00001,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_582893_1 1286632.P278_31310 1.75e-84 269.0 28HMZ@1|root,2Z7WD@2|Bacteria,4P095@976|Bacteroidetes 2|Bacteria S Protein of unknown function (DUF3604) - - - - - - - - - - - - DUF3604 k59_243927_1 1415778.JQMM01000001_gene1393 5.22e-12 62.8 COG3245@1|root,COG3245@2|Bacteria,1PC2P@1224|Proteobacteria,1SIYI@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Cytochrome C oxidase, cbb3-type, subunit III - - - - - - - - - - - - Cytochrome_CBB3 k59_243927_2 1120970.AUBZ01000029_gene1051 2.45e-57 180.0 COG2346@1|root,COG2346@2|Bacteria,1QBDE@1224|Proteobacteria,1S9FC@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Group 1 truncated hemoglobin - - - ko:K06886 - - - - ko00000 - - - Bac_globin k59_525987_1 1244528.CFT03427_0916 8.84e-20 86.3 COG1580@1|root,COG1580@2|Bacteria,1NBUX@1224|Proteobacteria,42RSV@68525|delta/epsilon subdivisions,2YPAW@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria N Controls the rotational direction of flagella during chemotaxis fliL - - ko:K02415 - - - - ko00000,ko02035 - - - FliL k59_525987_2 1118235.CAJH01000037_gene2293 4.63e-18 88.2 COG1868@1|root,COG1868@2|Bacteria,1MX01@1224|Proteobacteria,1RQ8M@1236|Gammaproteobacteria,1X3U1@135614|Xanthomonadales 135614|Xanthomonadales N FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation fliM - - ko:K02416 ko02030,ko02040,map02030,map02040 - - - ko00000,ko00001,ko02035 - - - FliM,FliMN_C k59_639725_1 697303.Thewi_0401 3.29e-37 139.0 COG1609@1|root,COG1609@2|Bacteria,1UC4I@1239|Firmicutes,249FZ@186801|Clostridia,42FJM@68295|Thermoanaerobacterales 186801|Clostridia K Periplasmic binding protein LacI transcriptional regulator - - - ko:K02529 - - - - ko00000,ko03000 - - - LacI,Peripla_BP_1,Peripla_BP_3 k59_639725_2 391625.PPSIR1_27478 2.26e-86 279.0 COG3459@1|root,COG3459@2|Bacteria,1MVNX@1224|Proteobacteria,42PFN@68525|delta/epsilon subdivisions,2WJVD@28221|Deltaproteobacteria,2YV3K@29|Myxococcales 28221|Deltaproteobacteria G Glycosyl hydrolase 36 superfamily, catalytic domain - - 2.4.1.20 ko:K00702,ko:K13688 ko00500,ko01100,map00500,map01100 - R00952 RC00049 ko00000,ko00001,ko01000,ko01003 - GH94,GT36,GT84 - Glyco_hydro_36,Glyco_transf_36,Glycoamylase k59_1036229_1 1240350.AMZE01000011_gene3698 3.86e-96 292.0 COG0112@1|root,COG0112@2|Bacteria,1MUIS@1224|Proteobacteria,1RMHQ@1236|Gammaproteobacteria,1YXH3@136845|Pseudomonas putida group 1236|Gammaproteobacteria E Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism glyA - 2.1.2.1 ko:K00600 ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523 M00140,M00141,M00346,M00532 R00945,R09099 RC00022,RC00112,RC01583,RC02958 ko00000,ko00001,ko00002,ko01000 - - - SHMT k59_922091_2 1122137.AQXF01000001_gene2761 4.72e-98 310.0 COG2866@1|root,COG2866@2|Bacteria,1N9W9@1224|Proteobacteria,2U2SA@28211|Alphaproteobacteria 28211|Alphaproteobacteria E carboxypeptidase - - - - - - - - - - - - Peptidase_M14 k59_413555_1 266835.14023600 2.38e-26 113.0 COG0457@1|root,COG1933@1|root,COG2114@1|root,COG3899@1|root,COG0457@2|Bacteria,COG1933@2|Bacteria,COG2114@2|Bacteria,COG3899@2|Bacteria,1MUDT@1224|Proteobacteria,2TQVN@28211|Alphaproteobacteria 28211|Alphaproteobacteria T Adenylate and Guanylate cyclase catalytic domain - - 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 - - - AAA_16,DZR,Guanylate_cyc,TPR_12 k59_752496_1 1463853.JOHW01000002_gene5744 0.000607 43.1 COG2272@1|root,COG2272@2|Bacteria,2GJCN@201174|Actinobacteria 201174|Actinobacteria I Belongs to the type-B carboxylesterase lipase family - - - ko:K03929 - - - - ko00000,ko01000 - CE10 - COesterase k59_133086_1 1122137.AQXF01000007_gene3590 3.1e-72 231.0 COG0364@1|root,COG0364@2|Bacteria,1MUN0@1224|Proteobacteria,2TQXA@28211|Alphaproteobacteria 28211|Alphaproteobacteria G Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone zwf - 1.1.1.363,1.1.1.49 ko:K00036 ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230 M00004,M00006,M00008 R00835,R02736,R10907 RC00001,RC00066 ko00000,ko00001,ko00002,ko01000,ko04147 - - - G6PD_C,G6PD_N k59_133086_2 1122137.AQXF01000007_gene3589 5.78e-16 75.5 COG0363@1|root,COG0363@2|Bacteria,1R5K6@1224|Proteobacteria 1224|Proteobacteria G 6-phosphogluconolactonase pgl - 3.1.1.31 ko:K01057 ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200 M00004,M00006,M00008 R02035 RC00537 ko00000,ko00001,ko00002,ko01000 - - - Glucosamine_iso k59_1038011_1 1137281.D778_00972 2.17e-96 301.0 COG1200@1|root,COG1200@2|Bacteria,4NDZV@976|Bacteroidetes,1HX1Z@117743|Flavobacteriia 976|Bacteroidetes L Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) recG - 3.6.4.12 ko:K03655 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,Helicase_C,RecG_wedge k59_868319_1 1121373.KB903664_gene2654 1.87e-53 187.0 COG3119@1|root,COG3119@2|Bacteria,4NEBN@976|Bacteroidetes,47MT5@768503|Cytophagia 976|Bacteroidetes P Sulfatase - - 3.1.6.1 ko:K01130 ko00140,ko00600,map00140,map00600 - R03980,R04856 RC00128,RC00231 ko00000,ko00001,ko01000 - - - Sulfatase k59_471644_1 330214.NIDE4115 4.71e-148 424.0 COG0436@1|root,COG0436@2|Bacteria,3J0ED@40117|Nitrospirae 40117|Nitrospirae E Aminotransferase class I and II - - - ko:K14261 - - - - ko00000,ko01000,ko01007 - - - Aminotran_1_2 k59_1714668_1 502025.Hoch_6440 5.93e-187 561.0 COG0145@1|root,COG0146@1|root,COG0145@2|Bacteria,COG0146@2|Bacteria,1MU2Y@1224|Proteobacteria,42NFP@68525|delta/epsilon subdivisions,2X7WN@28221|Deltaproteobacteria,2YXQ6@29|Myxococcales 28221|Deltaproteobacteria EQ Hydantoinase B/oxoprolinase - - 3.5.2.9 ko:K01469 ko00480,map00480 - R00251 RC00553 ko00000,ko00001,ko01000 - - - Hydant_A_N,Hydantoinase_A,Hydantoinase_B k59_641277_1 1120983.KB894571_gene2209 1.78e-32 122.0 2ER8M@1|root,33IU6@2|Bacteria,1NBUC@1224|Proteobacteria,2UFGX@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_245686_1 926569.ANT_06590 1.28e-93 281.0 COG2199@1|root,COG3706@2|Bacteria,2G85T@200795|Chloroflexi 200795|Chloroflexi T Response regulator receiver - - - - - - - - - - - - GGDEF,Response_reg k59_868328_1 257313.BP0489 1.21e-62 211.0 COG0187@1|root,COG0187@2|Bacteria,1MVKT@1224|Proteobacteria,2VI8N@28216|Betaproteobacteria,3T1KC@506|Alcaligenaceae 28216|Betaproteobacteria L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrB - 5.99.1.3 ko:K02470 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim k59_868328_2 1163617.SCD_n00002 8.15e-31 118.0 COG0592@1|root,COG0592@2|Bacteria,1MVD9@1224|Proteobacteria,2VH9B@28216|Betaproteobacteria 28216|Betaproteobacteria L Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria dnaN - 2.7.7.7 ko:K02338 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_beta,DNA_pol3_beta_2,DNA_pol3_beta_3 k59_1601896_1 1123325.JHUV01000011_gene1355 4.72e-09 56.6 COG1186@1|root,COG1186@2|Bacteria,2G3P3@200783|Aquificae 200783|Aquificae J Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA prfB - - ko:K02836 - - - - ko00000,ko03012 - - - PCRF,RF-1 k59_1601896_2 1246995.AFR_05845 7.46e-43 147.0 COG2884@1|root,COG2884@2|Bacteria,2GJE1@201174|Actinobacteria,4DAY4@85008|Micromonosporales 201174|Actinobacteria D cell division ATP-binding protein FtsE ftsE GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0008144,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0030145,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0044464,GO:0046872,GO:0046914,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - ko:K09812 ko02010,map02010 M00256 - - ko00000,ko00001,ko00002,ko02000,ko03036 3.A.1.140 - - ABC_tran k59_754110_1 1095769.CAHF01000022_gene339 2.66e-09 62.0 COG4966@1|root,COG4966@2|Bacteria,1RC4Q@1224|Proteobacteria,2VS7N@28216|Betaproteobacteria,476YR@75682|Oxalobacteraceae 28216|Betaproteobacteria NU Type IV Pilus-assembly protein W pilW - - ko:K02672 - - - - ko00000,ko02035,ko02044 - - - N_methyl,PilW k59_754110_2 765914.ThisiDRAFT_2222 8.58e-21 90.5 COG4967@1|root,COG4967@2|Bacteria,1N6TG@1224|Proteobacteria,1SC9Z@1236|Gammaproteobacteria,1WZQB@135613|Chromatiales 135613|Chromatiales NU TIGRFAM type IV pilus modification protein PilV - - - ko:K02671 - - - - ko00000,ko02035,ko02044 - - - N_methyl k59_1658893_1 1247963.JPHU01000011_gene844 1.04e-151 457.0 COG1629@1|root,COG1629@2|Bacteria,COG4771@2|Bacteria,1MU9K@1224|Proteobacteria,2TTJG@28211|Alphaproteobacteria 28211|Alphaproteobacteria P receptor - - - - - - - - - - - - Plug,TonB_dep_Rec k59_415131_1 349161.Dred_2805 8.88e-57 199.0 COG0067@1|root,COG0069@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,1TQ0B@1239|Firmicutes,248IB@186801|Clostridia,260N1@186807|Peptococcaceae 186801|Clostridia E glutamate synthase gltB - 1.4.1.13,1.4.1.14,1.4.7.1 ko:K00265,ko:K00284 ko00250,ko00630,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00630,map00910,map01100,map01110,map01120,map01130,map01230 - R00021,R00093,R00114,R00248,R10086 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - GATase_2,GXGXG,Glu_syn_central,Glu_synthase k59_133112_1 1041159.AZUW01000007_gene5304 2.93e-17 82.8 COG0577@1|root,COG0577@2|Bacteria,1MW6D@1224|Proteobacteria,2TTJZ@28211|Alphaproteobacteria,4B8CP@82115|Rhizobiaceae 28211|Alphaproteobacteria V FtsX-like permease family - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_133112_2 246200.SPO1497 8.3e-18 84.3 COG0845@1|root,COG0845@2|Bacteria,1Q10W@1224|Proteobacteria,2TSC8@28211|Alphaproteobacteria 28211|Alphaproteobacteria M Efflux transporter, RND family, MFP subunit - - - ko:K02005 - - - - ko00000 - - - HlyD_3 k59_527549_2 1038858.AXBA01000026_gene1628 1.84e-49 172.0 COG1804@1|root,COG1804@2|Bacteria,1MU5U@1224|Proteobacteria,2TRIZ@28211|Alphaproteobacteria 28211|Alphaproteobacteria C L-carnitine dehydratase bile acid-inducible protein F - - - - - - - - - - - - CoA_transf_3 k59_1319579_1 436308.Nmar_0490 9.38e-88 270.0 COG0001@1|root,arCOG00918@2157|Archaea,41SDE@651137|Thaumarchaeota 651137|Thaumarchaeota H PFAM aminotransferase class-III hemL - 5.4.3.8 ko:K01845 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R02272 RC00677 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 k59_979345_1 1286093.C266_22715 2.04e-65 220.0 COG0497@1|root,COG0497@2|Bacteria,1MUNP@1224|Proteobacteria,2VHHA@28216|Betaproteobacteria,1K174@119060|Burkholderiaceae 28216|Betaproteobacteria L May be involved in recombinational repair of damaged DNA recN - - ko:K03631 - - - - ko00000,ko03400 - - - SMC_N k59_20215_1 1144319.PMI16_04976 0.000168 50.1 COG0583@1|root,COG0583@2|Bacteria,1N3XX@1224|Proteobacteria,2W917@28216|Betaproteobacteria,4772M@75682|Oxalobacteraceae 28216|Betaproteobacteria K LysR substrate binding domain - - - - - - - - - - - - HTH_1,LysR_substrate k59_415144_1 350054.Mflv_1791 2.73e-115 341.0 COG1804@1|root,COG1804@2|Bacteria,2GIU7@201174|Actinobacteria,233ZH@1762|Mycobacteriaceae 201174|Actinobacteria C L-carnitine dehydratase bile acid-inducible protein F - - - - - - - - - - - - CoA_transf_3 k59_415144_2 158500.BV97_02780 5.57e-11 61.6 COG1960@1|root,COG1960@2|Bacteria,1MVAH@1224|Proteobacteria,2TR02@28211|Alphaproteobacteria,2K124@204457|Sphingomonadales 204457|Sphingomonadales I acyl-CoA dehydrogenase - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_1149601_1 243090.RB9857 1.81e-78 263.0 COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,2IY5P@203682|Planctomycetes 203682|Planctomycetes E Methionine synthase - - 2.1.1.13 ko:K00548 ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230 M00017 R00946,R09365 RC00035,RC00113,RC01241 ko00000,ko00001,ko00002,ko01000 - - - B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans k59_245714_1 391615.ABSJ01000042_gene2266 8.13e-30 119.0 COG2198@1|root,COG2198@2|Bacteria,1NFSM@1224|Proteobacteria,1SI4G@1236|Gammaproteobacteria 1236|Gammaproteobacteria T COG0643 Chemotaxis protein histidine kinase and related kinases - - - ko:K02487,ko:K06596 ko02020,ko02025,map02020,map02025 M00507 - - ko00000,ko00001,ko00002,ko01001,ko02022,ko02035 - - - Hpt k59_1262356_1 388739.RSK20926_05017 8.15e-85 272.0 COG1574@1|root,COG1574@2|Bacteria,1MWP2@1224|Proteobacteria,2TXAW@28211|Alphaproteobacteria,2P46E@2433|Roseobacter 28211|Alphaproteobacteria S metal-dependent hydrolase with the TIM-barrel fold - - - - - - - - - - - - Amidohydro_3 k59_1601934_1 1380391.JIAS01000013_gene3483 6.29e-76 238.0 COG2326@1|root,COG2326@2|Bacteria,1MVE2@1224|Proteobacteria,2TSU8@28211|Alphaproteobacteria,2JPV0@204441|Rhodospirillales 204441|Rhodospirillales S Polyphosphate kinase 2 (PPK2) - - - - - - - - - - - - PPK2 k59_20229_1 945713.IALB_1901 1.91e-37 145.0 COG4590@1|root,COG4590@2|Bacteria 2|Bacteria P Binding-protein-dependent transport system inner membrane component pstC - - ko:K02037,ko:K02038 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - BPD_transp_1 k59_1431923_1 436308.Nmar_1790 0.0 950.0 COG0174@1|root,arCOG01909@2157|Archaea,41SD6@651137|Thaumarchaeota 651137|Thaumarchaeota E TIGRFAM glutamine synthetase, type I - - 6.3.1.2 ko:K01915 ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 - R00253 RC00010,RC02798 ko00000,ko00001,ko01000,ko04147 - - - Gln-synt_C,Gln-synt_N k59_1206486_1 991.IW20_05255 2.64e-42 138.0 COG0361@1|root,COG0361@2|Bacteria,4NS6S@976|Bacteroidetes,1I3WQ@117743|Flavobacteriia,2NX5N@237|Flavobacterium 976|Bacteroidetes J One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex infA GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0043021,GO:0043022,GO:0044424,GO:0044444,GO:0044464,GO:0044877 - ko:K02518 - - - - ko00000,ko03012 - - - eIF-1a k59_1206486_2 553178.CAPGI0001_0439 4.73e-18 77.8 COG0099@1|root,COG0099@2|Bacteria,4NNGZ@976|Bacteroidetes,1I1ZW@117743|Flavobacteriia,1ERXC@1016|Capnocytophaga 976|Bacteroidetes J Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits rpsM GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022613,GO:0032991,GO:0034641,GO:0034645,GO:0042254,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02952 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S13 k59_1545773_1 398525.KB900701_gene6702 3.19e-123 374.0 COG3119@1|root,COG3119@2|Bacteria,1MV92@1224|Proteobacteria,2TTXG@28211|Alphaproteobacteria,3JVJZ@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria P Sulfatase - - 3.1.6.1 ko:K01130 ko00140,ko00600,map00140,map00600 - R03980,R04856 RC00128,RC00231 ko00000,ko00001,ko01000 - - - Sulfatase k59_697929_1 13689.BV96_02973 2.35e-14 69.3 COG1522@1|root,COG1522@2|Bacteria,1MX7R@1224|Proteobacteria,2VG6E@28211|Alphaproteobacteria,2K4V8@204457|Sphingomonadales 204457|Sphingomonadales K helix_turn_helix ASNC type - - - ko:K03719 - - - - ko00000,ko03000,ko03036 - - - AsnC_trans_reg,HTH_24 k59_697929_2 688245.CtCNB1_4257 1.86e-67 210.0 COG3128@1|root,COG3128@2|Bacteria,1MUI7@1224|Proteobacteria,2VJHT@28216|Betaproteobacteria,4ACJF@80864|Comamonadaceae 28216|Betaproteobacteria C PKHD-type hydroxylase - - - ko:K07336 - - - - ko00000,ko01000 - - - 2OG-FeII_Oxy_3 k59_979364_2 391615.ABSJ01000054_gene1457 2.87e-32 120.0 COG0457@1|root,COG0457@2|Bacteria,1N3T7@1224|Proteobacteria,1T1KY@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Tetratricopeptide repeat - - - - - - - - - - - - TPR_19 k59_303198_1 436308.Nmar_0034 1.57e-75 237.0 COG2512@1|root,arCOG00374@2157|Archaea,41SUX@651137|Thaumarchaeota 651137|Thaumarchaeota K membrane-associated protein domain - - - - - - - - - - - - - k59_303199_1 999141.GME_12399 4.61e-21 86.7 COG1734@1|root,COG1734@2|Bacteria,1RD08@1224|Proteobacteria,1S47H@1236|Gammaproteobacteria,1XJPG@135619|Oceanospirillales 135619|Oceanospirillales T Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters. Also required for regulation of fis expression dksA - - ko:K06204 ko02026,map02026 - - - ko00000,ko00001,ko03000,ko03009,ko03021 - - - zf-dskA_traR k59_303199_2 675817.VDA_001217 8.81e-34 125.0 COG0008@1|root,COG0008@2|Bacteria,1MUN7@1224|Proteobacteria,1RMYQ@1236|Gammaproteobacteria,1XTZH@135623|Vibrionales 135623|Vibrionales J Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon gluQ - - ko:K01894 - - - - ko00000,ko01000,ko01007,ko03016 - - - tRNA-synt_1c k59_987295_1 1284708.HMPREF1634_06865 0.000262 44.3 COG2986@1|root,COG2986@2|Bacteria,1TPCW@1239|Firmicutes,247XP@186801|Clostridia,3WCEP@538999|Clostridiales incertae sedis 186801|Clostridia E Aromatic amino acid lyase hutH - 4.3.1.3 ko:K01745 ko00340,ko01100,map00340,map01100 M00045 R01168 RC00361 ko00000,ko00001,ko00002,ko01000 - - - Lyase_aromatic k59_423829_1 525368.HMPREF0591_2927 9.89e-105 313.0 COG2141@1|root,COG2141@2|Bacteria,2GJRF@201174|Actinobacteria,2361K@1762|Mycobacteriaceae 201174|Actinobacteria C Catalyzes the reduction of the keto moiety of phthiodiolone dimycocerosates (DIM B) and glycosylated phenolphthiodiolone dimycocerosates to form the intermediate compounds phthiotriol and glycosylated phenolphthiotriol dimycocerosates during phthiocerol dimycocerosates (DIM A) and glycosylated phenolphthiocerol dimycocerosates (PGL) biosynthesis - - - ko:K14728 - - - - ko00000,ko01000 - - - Bac_luciferase k59_1327208_1 1121004.ATVC01000016_gene1763 6.04e-35 132.0 COG1804@1|root,COG1804@2|Bacteria,1MW1H@1224|Proteobacteria,2VJJQ@28216|Betaproteobacteria 28216|Betaproteobacteria C L-carnitine dehydratase bile acid-inducible protein F - - 5.1.99.4 ko:K01796 ko00120,ko01100,ko04146,map00120,map01100,map04146 M00104 R08734,R08739 RC02345 ko00000,ko00001,ko00002,ko01000 - - - CoA_transf_3 k59_708745_1 491952.Mar181_1595 2.27e-110 331.0 COG2059@1|root,COG2059@2|Bacteria,1MUBW@1224|Proteobacteria,1RPNP@1236|Gammaproteobacteria,1XH2D@135619|Oceanospirillales 135619|Oceanospirillales P Chromate - - - ko:K07240 - - - - ko00000,ko02000 2.A.51.1 - - Chromate_transp k59_31325_1 977880.RALTA_B0595 4.74e-53 176.0 COG1024@1|root,COG1024@2|Bacteria,1MVPQ@1224|Proteobacteria,2VMSU@28216|Betaproteobacteria,1K6EE@119060|Burkholderiaceae 28216|Betaproteobacteria I Enoyl-CoA hydratase/isomerase - - - - - - - - - - - - ECH_1 k59_708746_1 1144305.PMI02_04083 1.74e-182 513.0 COG3328@1|root,COG3328@2|Bacteria,1MU4P@1224|Proteobacteria,2TUQT@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Transposase - - - - - - - - - - - - Transposase_mut k59_1500574_1 1144310.PMI07_000602 4.57e-17 83.2 COG0136@1|root,COG0136@2|Bacteria,1MUHG@1224|Proteobacteria,2TSRD@28211|Alphaproteobacteria,4B7QX@82115|Rhizobiaceae 28211|Alphaproteobacteria E Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate asd - 1.2.1.11 ko:K00133 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00017,M00018,M00033,M00525,M00526,M00527 R02291 RC00684 ko00000,ko00001,ko00002,ko01000 - - - Semialdhyde_dh,Semialdhyde_dhC k59_1500574_2 1121033.AUCF01000007_gene5872 3.18e-62 203.0 COG0101@1|root,COG0101@2|Bacteria,1MUYI@1224|Proteobacteria,2TR57@28211|Alphaproteobacteria,2JQQ7@204441|Rhodospirillales 204441|Rhodospirillales J Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs truA - 5.4.99.12 ko:K06173 - - - - ko00000,ko01000,ko03016 - - - PseudoU_synth_1 k59_1500574_3 644966.Tmar_2262 2.27e-59 188.0 COG0102@1|root,COG0102@2|Bacteria,1V3HX@1239|Firmicutes,24HD9@186801|Clostridia,3WD6S@538999|Clostridiales incertae sedis 186801|Clostridia J This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly rplM - - ko:K02871 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L13 k59_1500574_4 877415.JNJQ01000004_gene1414 1.88e-48 159.0 COG0103@1|root,COG0103@2|Bacteria,1V3MQ@1239|Firmicutes,3VQHJ@526524|Erysipelotrichia 526524|Erysipelotrichia J Belongs to the universal ribosomal protein uS9 family rpsI - - ko:K02996 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S9 k59_1217129_1 435908.IDSA_05405 1.04e-77 248.0 COG1972@1|root,COG1972@2|Bacteria,1MXXX@1224|Proteobacteria,1RMBX@1236|Gammaproteobacteria,2QFAS@267893|Idiomarinaceae 1236|Gammaproteobacteria U Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family yeiM GO:0003674,GO:0005215,GO:0005337,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0015858,GO:0015931,GO:0015932,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:1901264,GO:1901505,GO:1901642 - ko:K03317 - - - - ko00000 2.A.41 - - Gate,Nucleos_tra2_C,Nucleos_tra2_N k59_1439865_1 1120999.JONM01000010_gene4072 3.16e-45 155.0 COG2857@1|root,COG2857@2|Bacteria,1QFU2@1224|Proteobacteria,2VIR6@28216|Betaproteobacteria,2KPTF@206351|Neisseriales 206351|Neisseriales C Cytochrome C1 petC - - ko:K00413 ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016 M00151,M00152 - - ko00000,ko00001,ko00002 - - - Cytochrom_C1 k59_762589_2 1120947.ATUX01000010_gene283 1.94e-14 71.6 COG1716@1|root,COG1716@2|Bacteria,2GKA7@201174|Actinobacteria,4D52E@85005|Actinomycetales 201174|Actinobacteria T FHA domain protein fhaB GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0006950,GO:0006979,GO:0008150,GO:0009987,GO:0016020,GO:0040007,GO:0044110,GO:0044116,GO:0044117,GO:0044119,GO:0044403,GO:0044419,GO:0044464,GO:0050896,GO:0051301,GO:0051704,GO:0071944 - - - - - - - - - - FHA,Yop-YscD_cpl k59_1271311_1 199310.c2344 5.95e-136 393.0 COG2391@1|root,COG2391@2|Bacteria,1PF9B@1224|Proteobacteria,1RNE8@1236|Gammaproteobacteria,3XN3Y@561|Escherichia 1236|Gammaproteobacteria S Sulphur transport yedE GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 - ko:K07112 - - - - ko00000 - - - Sulf_transp k59_372162_1 765869.BDW_02015 1e-57 186.0 COG3155@1|root,COG3155@2|Bacteria,1MW2K@1224|Proteobacteria,42R54@68525|delta/epsilon subdivisions,2MTY9@213481|Bdellovibrionales,2WMNZ@28221|Deltaproteobacteria 213481|Bdellovibrionales Q PFAM ThiJ PfpI domain protein elbB - - - - - - - - - - - DJ-1_PfpI k59_1160511_1 666684.AfiDRAFT_1781 1.12e-56 192.0 COG4992@1|root,COG4992@2|Bacteria,1R6U9@1224|Proteobacteria,2TUDK@28211|Alphaproteobacteria,3JTSX@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria E Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family MA20_16020 - 2.6.1.13 ko:K00819 ko00330,ko01100,ko01110,ko01130,map00330,map01100,map01110,map01130 - R00667 RC00006,RC00062 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_3 k59_372166_1 1337093.MBE-LCI_2049 1.35e-36 136.0 COG2223@1|root,COG2223@2|Bacteria,1MWC7@1224|Proteobacteria,2TWNV@28211|Alphaproteobacteria 28211|Alphaproteobacteria P Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 k59_480299_1 1229909.NSED_06905 8.89e-103 318.0 COG3808@1|root,arCOG04949@2157|Archaea,41SZG@651137|Thaumarchaeota 651137|Thaumarchaeota C Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force hppA - 3.6.1.1 ko:K15987 ko00190,map00190 - - - ko00000,ko00001,ko01000 3.A.10.1 - - H_PPase k59_1388729_1 1121912.AUHD01000003_gene2975 5.91e-08 55.5 COG3088@1|root,COG3088@2|Bacteria,4NGHU@976|Bacteroidetes,1HY3G@117743|Flavobacteriia 976|Bacteroidetes O Psort location CytoplasmicMembrane, score - - - - - - - - - - - - - k59_1388729_2 1197477.IA57_05925 2e-109 321.0 COG1721@1|root,COG1721@2|Bacteria,4NE2N@976|Bacteroidetes,1HX4X@117743|Flavobacteriia 976|Bacteroidetes S protein (some members contain a von Willebrand factor type A (vWA) domain) - - - - - - - - - - - - DUF58 k59_480305_1 208439.AJAP_24010 2.89e-104 338.0 COG1028@1|root,COG2070@1|root,COG3321@1|root,COG1028@2|Bacteria,COG2070@2|Bacteria,COG3321@2|Bacteria,2H477@201174|Actinobacteria,4DZDB@85010|Pseudonocardiales 201174|Actinobacteria Q polyketide synthase - - - - - - - - - - - - Acyl_transf_1,KAsynt_C_assoc,KR,Ketoacyl-synt_C,NMO,PP-binding,PS-DH,ketoacyl-synt k59_1102404_1 710696.Intca_0369 2.09e-33 127.0 COG0596@1|root,COG1506@1|root,COG3710@1|root,COG0596@2|Bacteria,COG1506@2|Bacteria,COG3710@2|Bacteria,2HASC@201174|Actinobacteria 201174|Actinobacteria K Transcriptional regulatory protein, C terminal - - - - - - - - - - - - Trans_reg_C k59_710051_2 1209072.ALBT01000008_gene2970 1.39e-62 215.0 COG0308@1|root,COG0308@2|Bacteria,1MUCI@1224|Proteobacteria,1RMA7@1236|Gammaproteobacteria,1FGPJ@10|Cellvibrio 1236|Gammaproteobacteria E Domain of unknown function (DUF3458_C) ARM repeats pepN GO:0003674,GO:0003824,GO:0004177,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006508,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008235,GO:0008237,GO:0008238,GO:0008270,GO:0009056,GO:0009987,GO:0016020,GO:0016787,GO:0019538,GO:0033218,GO:0034641,GO:0042277,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0043171,GO:0043603,GO:0044237,GO:0044238,GO:0044248,GO:0044424,GO:0044464,GO:0046872,GO:0046914,GO:0070006,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901565,GO:1901575 3.4.11.2 ko:K01256 ko00480,ko01100,map00480,map01100 - R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 - - iECIAI1_1343.ECIAI1_0973,iECO103_1326.ECO103_0977,iECP_1309.ECP_0944,iECSE_1348.ECSE_0993,iECW_1372.ECW_m1042,iEKO11_1354.EKO11_2898,iWFL_1372.ECW_m1042 DUF3458,DUF3458_C,Peptidase_M1 k59_1328098_1 1229909.NSED_01655 2.02e-53 178.0 arCOG08643@1|root,arCOG08643@2157|Archaea,41T2H@651137|Thaumarchaeota 651137|Thaumarchaeota S peptidyl-tyrosine sulfation - - - - - - - - - - - - - k59_988259_1 713586.KB900536_gene345 3.88e-99 323.0 COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,1RQ0G@1236|Gammaproteobacteria,1WXEX@135613|Chromatiales 135613|Chromatiales L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate - - - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - ABC_tran k59_880522_1 754476.Q7A_2971 4.8e-42 160.0 COG0658@1|root,COG2333@1|root,COG0658@2|Bacteria,COG2333@2|Bacteria,1MUKF@1224|Proteobacteria,1RMW6@1236|Gammaproteobacteria,45ZUT@72273|Thiotrichales 72273|Thiotrichales S DNA internalization-related competence protein ComEC Rec2 - - - ko:K02238 - M00429 - - ko00000,ko00002,ko02044 3.A.11.1,3.A.11.2 - - Competence,DUF4131,Lactamase_B k59_1726015_1 163908.KB235896_gene4281 1.21e-84 259.0 COG0668@1|root,COG0668@2|Bacteria,1G06A@1117|Cyanobacteria 1117|Cyanobacteria M COG0668 Small-conductance mechanosensitive channel - - - - - - - - - - - - MS_channel k59_1271334_1 4932.YPL283C 1.03e-117 374.0 2CNHI@1|root,2QWCT@2759|Eukaryota,39XTN@33154|Opisthokonta,3NYG1@4751|Fungi,3QNWA@4890|Ascomycota,3RU1R@4891|Saccharomycetes,3RZ5H@4893|Saccharomycetaceae 4751|Fungi A highly expressed in the mutants lacking the telomerase component TLC1 - GO:0000722,GO:0000723,GO:0003674,GO:0003678,GO:0003824,GO:0004386,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005739,GO:0006139,GO:0006259,GO:0006310,GO:0006312,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0032200,GO:0032392,GO:0032508,GO:0034641,GO:0042592,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051276,GO:0060249,GO:0065007,GO:0065008,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360 - - - - - - - - - - DEAD,Helicase_C,Sir1 k59_372190_1 1254432.SCE1572_08405 1.43e-76 243.0 COG3569@1|root,COG3569@2|Bacteria,1MVJ9@1224|Proteobacteria,4304Z@68525|delta/epsilon subdivisions,2WVJ8@28221|Deltaproteobacteria,2YV3F@29|Myxococcales 28221|Deltaproteobacteria L Eukaryotic DNA topoisomerase I, catalytic core topI - 5.99.1.2 ko:K03168 - - - - ko00000,ko01000,ko03032,ko03400 - - - Topoisom_I k59_424754_1 1384054.N790_11835 1.77e-68 219.0 COG2972@1|root,COG2972@2|Bacteria,1MXVQ@1224|Proteobacteria,1RQDA@1236|Gammaproteobacteria,1X5X6@135614|Xanthomonadales 135614|Xanthomonadales T Histidine kinase - - - - - - - - - - - - HATPase_c,His_kinase k59_1778582_1 187272.Mlg_1772 1.36e-67 226.0 COG0038@1|root,COG0517@1|root,COG0038@2|Bacteria,COG0517@2|Bacteria,1MV4K@1224|Proteobacteria,1RQJW@1236|Gammaproteobacteria,1WW2F@135613|Chromatiales 1236|Gammaproteobacteria P Chloride channel - - - - - - - - - - - - Voltage_CLC k59_650166_1 1379270.AUXF01000001_gene2597 2.2e-45 166.0 COG0433@1|root,COG0433@2|Bacteria,1ZUJE@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Domain of unknown function DUF87 - - - - - - - - - - - - DUF87 k59_32614_1 1288083.AUKR01000021_gene1527 3.26e-07 53.1 COG1362@1|root,COG1362@2|Bacteria,2GKW4@201174|Actinobacteria 201174|Actinobacteria E M18 family aminopeptidase apeB GO:0003674,GO:0003824,GO:0004177,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006508,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008235,GO:0008237,GO:0008238,GO:0009987,GO:0016020,GO:0016787,GO:0019538,GO:0034641,GO:0043170,GO:0043603,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0070006,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564 3.4.11.21 ko:K01267 - - - - ko00000,ko01000,ko01002,ko04131 - - - Peptidase_M18 k59_32614_2 1206744.BAGL01000038_gene493 2.92e-07 56.6 COG1680@1|root,COG1680@2|Bacteria,2GJJB@201174|Actinobacteria,4FX3F@85025|Nocardiaceae 201174|Actinobacteria V Beta-lactamase lipL - - - - - - - - - - - Beta-lactamase k59_1726023_1 1229909.NSED_09660 2.07e-68 212.0 COG2241@1|root,arCOG00650@2157|Archaea,41SGN@651137|Thaumarchaeota 651137|Thaumarchaeota H TIGRFAM precorrin-6y C5,15-methyltransferase (decarboxylating), CbiE subunit - - 2.1.1.289 ko:K03399 ko00860,ko01100,map00860,map01100 - R05813,R07775 RC00003,RC02052,RC02053 ko00000,ko00001,ko01000 - - - TP_methylase k59_1726023_2 436308.Nmar_0004 1.56e-56 186.0 COG3794@1|root,arCOG02926@2157|Archaea 2157|Archaea C PFAM blue (type 1) copper domain protein - - - - - - - - - - - - Copper-bind,Cupredoxin_1 k59_820167_1 1121921.KB898706_gene2328 5.61e-67 207.0 COG2801@1|root,COG2801@2|Bacteria,1MVN5@1224|Proteobacteria,1RP6D@1236|Gammaproteobacteria 1236|Gammaproteobacteria L Transposase - - - ko:K07497 - - - - ko00000 - - - HTH_21,rve,rve_3 k59_199818_1 1175306.GWL_32920 1.07e-16 80.1 COG1660@1|root,COG1660@2|Bacteria,1MVX6@1224|Proteobacteria,2VIH5@28216|Betaproteobacteria,47677@75682|Oxalobacteraceae 28216|Betaproteobacteria S Displays ATPase and GTPase activities yhbJ - - ko:K06958 - - - - ko00000,ko03019 - - - ATP_bind_2 k59_1501908_1 1304888.ATWF01000001_gene1066 4.66e-86 269.0 COG4799@1|root,COG4799@2|Bacteria,2GEJS@200930|Deferribacteres 200930|Deferribacteres I Carboxyl transferase domain - - - - - - - - - - - - Carboxyl_trans k59_880552_1 1150469.RSPPHO_00318 2.48e-61 203.0 COG0343@1|root,COG0343@2|Bacteria,1MUCA@1224|Proteobacteria,2TR87@28211|Alphaproteobacteria,2JPNV@204441|Rhodospirillales 204441|Rhodospirillales J Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) tgt - 2.4.2.29 ko:K00773 - - R03789,R10209 RC00063 ko00000,ko01000,ko03016 - - - TGT k59_762635_2 867903.ThesuDRAFT_02073 1.25e-23 103.0 COG2265@1|root,COG2265@2|Bacteria,1TP4H@1239|Firmicutes,248B4@186801|Clostridia,3WCRW@538999|Clostridiales incertae sedis 186801|Clostridia J tRNA (Uracil-5-)-methyltransferase rumA - 2.1.1.190 ko:K03215 - - - - ko00000,ko01000,ko03009 - - - TRAM,tRNA_U5-meth_tr k59_1388778_1 519989.ECTPHS_03197 2.24e-114 350.0 COG0542@1|root,COG0542@2|Bacteria,1MV8B@1224|Proteobacteria,1RMH3@1236|Gammaproteobacteria,1WWT9@135613|Chromatiales 135613|Chromatiales O Belongs to the ClpA ClpB family clpA - - ko:K03694 - - - - ko00000,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N k59_315523_1 216142.LT40_05320 1.99e-97 303.0 COG0556@1|root,COG0556@2|Bacteria,1MUFK@1224|Proteobacteria,1RN6Z@1236|Gammaproteobacteria 1236|Gammaproteobacteria L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage uvrB GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009314,GO:0009380,GO:0009628,GO:0032991,GO:0042802,GO:0044424,GO:0044464,GO:0050896,GO:1902494,GO:1905347,GO:1905348,GO:1990391 - ko:K03702 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - Helicase_C,ResIII,UVR,UvrB k59_820200_1 316407.85676411 2.41e-93 281.0 COG0438@1|root,COG0438@2|Bacteria,1NE3V@1224|Proteobacteria,1RQE3@1236|Gammaproteobacteria,3XNUU@561|Escherichia 1236|Gammaproteobacteria M Lipopolysaccharide core biosynthesis protein RfaG rfaG GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008194,GO:0008610,GO:0008653,GO:0008919,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033692,GO:0034637,GO:0034645,GO:0035251,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0046401,GO:0046527,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 - ko:K02844 ko00540,ko01100,map00540,map01100 M00080 - - ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT4 iSDY_1059.SDY_4061 Glyco_transf_4,Glycos_transf_1 k59_820200_2 316407.85676410 7.85e-61 195.0 COG0859@1|root,COG0859@2|Bacteria,1MYZA@1224|Proteobacteria,1RR6K@1236|Gammaproteobacteria,3XMTY@561|Escherichia 1236|Gammaproteobacteria M Catalyzes heptose transfer to the lipopolysaccharide core. It transfers a heptose, called heptose(III), to the heptose(II) of the inner core rfaQ GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0008713,GO:0008920,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016740,GO:0016757,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0046401,GO:0071704,GO:0071967,GO:1901135,GO:1901137,GO:1901576,GO:1903509 - ko:K02849 ko00540,ko01100,map00540,map01100 M00080 - - ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT9 iAF1260.b3632,iBWG_1329.BWG_3323,iECDH10B_1368.ECDH10B_3814,iJO1366.b3632,iSSON_1240.SSON_3775,iY75_1357.Y75_RS18975 Glyco_transf_9 k59_1668166_1 136037.KDR24329 8.38e-13 71.6 COG0591@1|root,KOG3761@2759|Eukaryota,39WU2@33154|Opisthokonta,3BMZ0@33208|Metazoa,3D51W@33213|Bilateria,41X8C@6656|Arthropoda,3SHZF@50557|Insecta 33208|Metazoa I Sodium:solute symporter family - - - ko:K14387 ko04725,ko05231,map04725,map05231 - - - ko00000,ko00001,ko02000 2.A.21.8 - - SSF k59_710106_1 1380390.JIAT01000013_gene64 6.31e-14 71.2 COG1678@1|root,COG1678@2|Bacteria,2GNRA@201174|Actinobacteria,4CQ9B@84995|Rubrobacteria 84995|Rubrobacteria K Uncharacterized ACR, COG1678 - - - ko:K07735 - - - - ko00000,ko03000 - - - DUF179 k59_710106_2 1122179.KB890453_gene4624 9.38e-21 92.4 COG1235@1|root,COG1235@2|Bacteria,4NGB4@976|Bacteroidetes 976|Bacteroidetes S Pyrroloquinoline quinone biosynthesis protein PqqB - - - ko:K06136 - - - - ko00000 - - - Lactamase_B_2 k59_1160591_1 1121943.KB899995_gene856 9.64e-40 142.0 COG1670@1|root,COG1670@2|Bacteria,1MXEE@1224|Proteobacteria,1S2G5@1236|Gammaproteobacteria,1XJMZ@135619|Oceanospirillales 135619|Oceanospirillales J Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_3 k59_880576_1 1323361.JPOC01000020_gene2480 5.67e-52 180.0 COG1012@1|root,COG1012@2|Bacteria,2GIWZ@201174|Actinobacteria,4FTXB@85025|Nocardiaceae 201174|Actinobacteria C Belongs to the aldehyde dehydrogenase family - - - - - - - - - - - - Aldedh k59_372247_1 317013.NY99_09640 2.7e-73 250.0 COG2352@1|root,COG2352@2|Bacteria,1MUD5@1224|Proteobacteria,1RPTP@1236|Gammaproteobacteria,1X4MI@135614|Xanthomonadales 135614|Xanthomonadales C Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle ppc GO:0003674,GO:0003824,GO:0004611,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008964,GO:0016829,GO:0016830,GO:0016831,GO:0044424,GO:0044444,GO:0044464 4.1.1.31 ko:K01595 ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200 M00168,M00170,M00171,M00172,M00173,M00346,M00374 R00345 RC02741 ko00000,ko00001,ko00002,ko01000 - - - PEPcase k59_480362_1 62928.azo2637 1.34e-61 195.0 COG2110@1|root,COG2110@2|Bacteria,1RCWP@1224|Proteobacteria,2VRGS@28216|Betaproteobacteria,2KWIF@206389|Rhodocyclales 206389|Rhodocyclales S Appr-1'-p processing enzyme - - - - - - - - - - - - Macro k59_1328152_1 323850.Shew_3085 7.26e-80 241.0 COG3040@1|root,COG3040@2|Bacteria,1RDAI@1224|Proteobacteria,1S3PW@1236|Gammaproteobacteria,2QBQR@267890|Shewanellaceae 1236|Gammaproteobacteria M Lipocalin-like domain blc GO:0005575,GO:0005623,GO:0006950,GO:0006974,GO:0008150,GO:0009279,GO:0009987,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0033554,GO:0044462,GO:0044464,GO:0050896,GO:0051716,GO:0071944 - ko:K03098 - - - - ko00000,ko04147 - - - Lipocalin_2 k59_1102473_1 555793.WSK_1653 5.81e-66 204.0 COG2001@1|root,COG2001@2|Bacteria,1RHCS@1224|Proteobacteria,2UJTK@28211|Alphaproteobacteria,2K6WD@204457|Sphingomonadales 204457|Sphingomonadales K Belongs to the MraZ family - - - ko:K03925 - - - - ko00000 - - - - k59_1160617_1 765914.ThisiDRAFT_1039 2.86e-142 420.0 COG0568@1|root,COG0568@2|Bacteria,1MVNJ@1224|Proteobacteria,1RMQI@1236|Gammaproteobacteria,1WWD1@135613|Chromatiales 135613|Chromatiales K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth rpoD - - ko:K03086 - - - - ko00000,ko03021 - - - Sigma70_ner,Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4 k59_650222_2 1415778.JQMM01000001_gene17 9.79e-56 179.0 COG0817@1|root,COG0817@2|Bacteria,1MUJI@1224|Proteobacteria,1RQPJ@1236|Gammaproteobacteria,1J63F@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group ruvC GO:0000725,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008821,GO:0009058,GO:0009059,GO:0009314,GO:0009628,GO:0009987,GO:0016787,GO:0016788,GO:0016889,GO:0016894,GO:0031297,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0045005,GO:0046483,GO:0048476,GO:0050896,GO:0051716,GO:0071704,GO:0071932,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901576 3.1.22.4 ko:K01159 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - RuvC k59_988326_1 1096930.L284_07830 3.16e-59 190.0 COG0024@1|root,COG0024@2|Bacteria,1MU99@1224|Proteobacteria,2TQTH@28211|Alphaproteobacteria,2K0AR@204457|Sphingomonadales 204457|Sphingomonadales E Methionine aminopeptidase map - 3.4.11.18 ko:K01265 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M24 k59_988326_2 702113.PP1Y_AT5573 3.43e-33 125.0 COG0260@1|root,COG0260@2|Bacteria,1MUIN@1224|Proteobacteria,2TSI6@28211|Alphaproteobacteria,2JZV7@204457|Sphingomonadales 204457|Sphingomonadales E Belongs to the peptidase M17 family - - 3.4.11.1 ko:K01255 ko00480,ko01100,map00480,map01100 - R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 - - - Peptidase_M17 k59_424818_1 316407.1799788 5.66e-88 268.0 COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,1RNB5@1236|Gammaproteobacteria 1236|Gammaproteobacteria C acyl-CoA transferases carnitine dehydratase frc GO:0003674,GO:0003824,GO:0008150,GO:0008410,GO:0009268,GO:0009628,GO:0009987,GO:0010447,GO:0016740,GO:0016782,GO:0033608,GO:0050896,GO:0051716,GO:0071214,GO:0071467,GO:0071468,GO:0104004 2.8.3.16 ko:K07749 - - - - ko00000,ko01000 - - - CoA_transf_3 k59_932616_1 479431.Namu_0972 3.85e-07 53.1 COG0500@1|root,COG2226@2|Bacteria,2GKFZ@201174|Actinobacteria,4ERZ2@85013|Frankiales 201174|Actinobacteria H Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) menG GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044464,GO:0071944 2.1.1.163,2.1.1.201 ko:K03183 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116,M00117 R04990,R04993,R06859,R08774,R09736 RC00003,RC01253,RC01662 ko00000,ko00001,ko00002,ko01000 - - - Ubie_methyltran k59_932616_2 946483.Cenrod_2652 4.79e-30 118.0 COG0172@1|root,COG0172@2|Bacteria,1MUJF@1224|Proteobacteria,2VHJJ@28216|Betaproteobacteria,4AAXF@80864|Comamonadaceae 28216|Betaproteobacteria J Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) serS - 6.1.1.11 ko:K01875 ko00970,map00970 M00359,M00360 R03662,R08218 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Seryl_tRNA_N,tRNA-synt_2b k59_372280_1 1449049.JONW01000009_gene4525 4.06e-25 106.0 COG4774@1|root,COG4774@2|Bacteria 2|Bacteria P siderophore transport - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_372281_1 1120999.JONM01000004_gene3677 6.18e-46 155.0 COG0352@1|root,COG0352@2|Bacteria,1RDSU@1224|Proteobacteria,2VSR5@28216|Betaproteobacteria,2KR43@206351|Neisseriales 206351|Neisseriales H Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) - - 2.5.1.3 ko:K00788 ko00730,ko01100,map00730,map01100 M00127 R03223,R10712 RC00224,RC03255,RC03397 ko00000,ko00001,ko00002,ko01000 - - - TMP-TENI k59_372281_2 323848.Nmul_A2627 3.84e-39 137.0 COG0351@1|root,COG0351@2|Bacteria,1MU9J@1224|Proteobacteria,2VKD2@28216|Betaproteobacteria,371SJ@32003|Nitrosomonadales 28216|Betaproteobacteria H Phosphomethylpyrimidine kinase thiD - 2.7.1.49,2.7.4.7 ko:K00941 ko00730,ko01100,map00730,map01100 M00127 R03471,R04509 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - Phos_pyr_kin k59_880614_1 887898.HMPREF0551_1235 1.06e-52 181.0 COG0195@1|root,COG0195@2|Bacteria,1MWT7@1224|Proteobacteria,2VH2X@28216|Betaproteobacteria,1K0A5@119060|Burkholderiaceae 28216|Betaproteobacteria K Participates in both transcription termination and antitermination nusA - - ko:K02600 - - - - ko00000,ko03009,ko03021 - - - HHH_5,KH_5,NusA_N,S1 k59_1271403_1 314278.NB231_08998 4.48e-17 82.4 COG1198@1|root,COG1198@2|Bacteria,1MUUZ@1224|Proteobacteria,1RPZ7@1236|Gammaproteobacteria,1WX60@135613|Chromatiales 135613|Chromatiales L Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA priA - - ko:K04066 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,Helicase_C,ResIII k59_1271403_2 95619.PM1_0203720 2.47e-27 102.0 COG1970@1|root,COG1970@2|Bacteria,1RHG8@1224|Proteobacteria,1S3PD@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell mscL GO:0003674,GO:0005215,GO:0005216,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006884,GO:0008150,GO:0008361,GO:0008381,GO:0009987,GO:0009992,GO:0015075,GO:0015267,GO:0015318,GO:0016020,GO:0016021,GO:0016043,GO:0019725,GO:0022803,GO:0022836,GO:0022838,GO:0022857,GO:0030104,GO:0031224,GO:0031226,GO:0032535,GO:0034220,GO:0042592,GO:0042802,GO:0044425,GO:0044459,GO:0044464,GO:0048878,GO:0051179,GO:0051234,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0071840,GO:0071944,GO:0090066 - ko:K03282 - - - - ko00000,ko02000 1.A.22.1 - - MscL k59_372286_1 702113.PP1Y_AT21673 2.84e-28 113.0 COG0367@1|root,COG0367@2|Bacteria,1MW4E@1224|Proteobacteria,2TSCY@28211|Alphaproteobacteria,2JZZC@204457|Sphingomonadales 204457|Sphingomonadales E Asparagine synthase asnB - 6.3.5.4 ko:K01953 ko00250,ko01100,ko01110,map00250,map01100,map01110 - R00578 RC00010 ko00000,ko00001,ko01000,ko01002 - - - Asn_synthase,GATase_7 k59_772006_1 667014.Thein_1982 3.93e-29 119.0 COG0569@1|root,COG0569@2|Bacteria,2GIEN@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria P Alanine dehydrogenase/PNT, C-terminal domain - - - ko:K03499 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - - TrkA_C,TrkA_N k59_997907_1 338963.Pcar_1945 1.87e-102 312.0 COG0504@1|root,COG0504@2|Bacteria,1MUIT@1224|Proteobacteria,42MEU@68525|delta/epsilon subdivisions,2WJ0F@28221|Deltaproteobacteria,43SE4@69541|Desulfuromonadales 28221|Deltaproteobacteria F CTP synthase N-terminus pyrG - 6.3.4.2 ko:K01937 ko00240,ko01100,map00240,map01100 M00052 R00571,R00573 RC00010,RC00074 ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_1276 CTP_synth_N,GATase k59_544850_1 1304885.AUEY01000006_gene755 2.39e-40 141.0 COG0639@1|root,COG0639@2|Bacteria,1RD8M@1224|Proteobacteria,42RQP@68525|delta/epsilon subdivisions,2WNQ7@28221|Deltaproteobacteria,2MK7M@213118|Desulfobacterales 28221|Deltaproteobacteria T Calcineurin-like phosphoesterase - - 3.1.3.16 ko:K07313 - - - - ko00000,ko01000 - - - Metallophos,Metallophos_2 k59_830725_1 1133849.O3I_002120 3.33e-16 85.5 COG1680@1|root,COG1680@2|Bacteria,2GIX5@201174|Actinobacteria,4FXY1@85025|Nocardiaceae 201174|Actinobacteria V COG1680 Beta-lactamase class C and other penicillin binding proteins - - 3.4.16.4 ko:K01286 - - - - ko00000,ko01000 - - - Beta-lactamase k59_1512244_1 697282.Mettu_1098 4.07e-17 92.4 COG0726@1|root,COG2931@1|root,COG0726@2|Bacteria,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,1RNK8@1236|Gammaproteobacteria,1XFUS@135618|Methylococcales 135618|Methylococcales QU COG2931 RTX toxins and related Ca2 -binding proteins - - - - - - - - - - - - - k59_1512244_2 172088.AUGA01000011_gene2699 7.56e-61 195.0 28M6T@1|root,2ZAKD@2|Bacteria,1MXS6@1224|Proteobacteria,2TV0T@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_1450671_2 1485544.JQKP01000001_gene1086 1.37e-44 154.0 COG1388@1|root,COG4942@1|root,COG1388@2|Bacteria,COG4942@2|Bacteria,1RD24@1224|Proteobacteria,2VINR@28216|Betaproteobacteria,44VQ0@713636|Nitrosomonadales 28216|Betaproteobacteria DM Lysin motif - - - ko:K06194 - - - - ko00000 1.A.34.1.2 - - LysM,Peptidase_M23 k59_268078_2 983545.Glaag_3851 1.76e-22 88.6 COG1476@1|root,COG1476@2|Bacteria,1N7BB@1224|Proteobacteria,1SCG8@1236|Gammaproteobacteria,468KU@72275|Alteromonadaceae 1236|Gammaproteobacteria K Helix-turn-helix domain - - - ko:K07729 - - - - ko00000,ko03000 - - - HTH_3 k59_268078_3 392499.Swit_1448 2.7e-07 53.1 COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2TR2W@28211|Alphaproteobacteria,2K311@204457|Sphingomonadales 204457|Sphingomonadales IQ AMP-binding enzyme C-terminal domain - - - ko:K00666 - - - - ko00000,ko01000,ko01004 - - - AMP-binding,AMP-binding_C k59_153061_1 1229909.NSED_00945 6.27e-92 282.0 COG1109@1|root,arCOG00767@2157|Archaea,41S74@651137|Thaumarchaeota 651137|Thaumarchaeota G Belongs to the phosphohexose mutase family - - 5.4.2.2,5.4.2.8 ko:K15778 ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130 M00114 R00959,R01057,R01818,R08639 RC00408 ko00000,ko00001,ko00002,ko01000 - - - PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV k59_891090_1 1268622.AVS7_04240 1.73e-55 187.0 COG4799@1|root,COG4799@2|Bacteria,1MVAX@1224|Proteobacteria,2VK54@28216|Betaproteobacteria,4AA50@80864|Comamonadaceae 28216|Betaproteobacteria I PFAM carboxyl transferase - - - - - - - - - - - - Carboxyl_trans k59_1337167_1 1122244.AUGF01000004_gene1313 2.89e-34 120.0 COG0776@1|root,COG0776@2|Bacteria,1MZ5B@1224|Proteobacteria,1S8VH@1236|Gammaproteobacteria,3NNVG@468|Moraxellaceae 1236|Gammaproteobacteria L Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions hupB - - ko:K03530 - - - - ko00000,ko03032,ko03036,ko03400 - - - Bac_DNA_binding k59_1787309_1 1229909.NSED_00715 1.18e-69 223.0 COG0141@1|root,arCOG04352@2157|Archaea,41S6J@651137|Thaumarchaeota 651137|Thaumarchaeota E Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine hisD - 1.1.1.23 ko:K00013 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R01158,R01163,R03012 RC00099,RC00242,RC00463 ko00000,ko00001,ko00002,ko01000 - - - Histidinol_dh k59_891094_1 864073.HFRIS_009600 1.71e-142 411.0 COG2025@1|root,COG2025@2|Bacteria,1MUFI@1224|Proteobacteria,2VI6W@28216|Betaproteobacteria,47253@75682|Oxalobacteraceae 28216|Betaproteobacteria C Electron transfer flavoprotein, alpha subunit - - - ko:K03522 - - - - ko00000,ko04147 - - - ETF,ETF_alpha k59_1280639_2 550540.Fbal_3790 1.17e-40 140.0 COG0711@1|root,COG0711@2|Bacteria,1RHZ0@1224|Proteobacteria,1S402@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) atpF GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0031224,GO:0031225,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0036442,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045263,GO:0045264,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0046961,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - ko:K02109 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - e_coli_core.b3736,iAF1260.b3736,iB21_1397.B21_03564,iBWG_1329.BWG_3427,iE2348C_1286.E2348C_4046,iEC042_1314.EC042_4123,iEC55989_1330.EC55989_4211,iECABU_c1320.ECABU_c42210,iECBD_1354.ECBD_4296,iECB_1328.ECB_03620,iECDH10B_1368.ECDH10B_3923,iECDH1ME8569_1439.ECDH1ME8569_3624,iECD_1391.ECD_03620,iECED1_1282.ECED1_4426,iECH74115_1262.ECH74115_5172,iECIAI1_1343.ECIAI1_3920,iECIAI39_1322.ECIAI39_4340,iECO103_1326.ECO103_4422,iECO111_1330.ECO111_4570,iECO26_1355.ECO26_4842,iECOK1_1307.ECOK1_4185,iECP_1309.ECP_3935,iECS88_1305.ECS88_4158,iECSE_1348.ECSE_4026,iECSF_1327.ECSF_3584,iECSP_1301.ECSP_4786,iECUMN_1333.ECUMN_4266,iECW_1372.ECW_m4039,iECs_1301.ECs4678,iEKO11_1354.EKO11_4609,iETEC_1333.ETEC_4027,iEcDH1_1363.EcDH1_4231,iEcE24377_1341.EcE24377A_4252,iEcHS_1320.EcHS_A3952,iEcSMS35_1347.EcSMS35_4104,iEcolC_1368.EcolC_4258,iG2583_1286.G2583_4532,iJO1366.b3736,iJR904.b3736,iSDY_1059.SDY_4012,iSFV_1184.SFV_3762,iSF_1195.SF3816,iSFxv_1172.SFxv_4159,iSSON_1240.SSON_3883,iS_1188.S3952,iSbBS512_1146.SbBS512_E4185,iUMN146_1321.UM146_18870,iUMNK88_1353.UMNK88_4548,iUTI89_1310.UTI89_C4291,iWFL_1372.ECW_m4039,iY75_1357.Y75_RS18390,iZ_1308.Z5234,ic_1306.c4664 ATP-synt_B k59_1569863_1 1122135.KB893134_gene3781 1.96e-86 276.0 COG0119@1|root,COG0119@2|Bacteria,1MUNQ@1224|Proteobacteria,2TSCJ@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) leuA - 2.3.3.13 ko:K01649 ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230 M00432 R01213 RC00004,RC00470,RC02754 br01601,ko00000,ko00001,ko00002,ko01000 - - - HMGL-like,LeuA_dimer k59_489749_1 1415778.JQMM01000001_gene897 1.15e-41 157.0 COG4223@1|root,COG4223@2|Bacteria,1N10X@1224|Proteobacteria,1RYCQ@1236|Gammaproteobacteria,1J4ZA@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T Protein of unknown function (DUF1631) - - - - - - - - - - - - DUF1631 k59_1227043_1 685035.ADAE01000003_gene2859 5.14e-37 131.0 COG0406@1|root,COG0406@2|Bacteria,1RM6N@1224|Proteobacteria,2UA44@28211|Alphaproteobacteria,2KD5S@204457|Sphingomonadales 204457|Sphingomonadales G Phosphoglycerate mutase family - - 3.1.3.73 ko:K02226 ko00860,ko01100,map00860,map01100 M00122 R04594,R11173 RC00017 ko00000,ko00001,ko00002,ko01000 - - - His_Phos_1 k59_1227043_2 1219049.SP5_022_00060 1.31e-23 97.4 COG0368@1|root,COG0368@2|Bacteria,1RHCC@1224|Proteobacteria,2U97D@28211|Alphaproteobacteria,2K3ZF@204457|Sphingomonadales 204457|Sphingomonadales H Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate cobS - 2.7.8.26 ko:K02233 ko00860,ko01100,map00860,map01100 M00122 R05223,R11174 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - CobS k59_721048_1 1216976.AX27061_1672 2.77e-84 258.0 COG0761@1|root,COG0761@2|Bacteria,1MU7G@1224|Proteobacteria,2VHM8@28216|Betaproteobacteria,3T1T0@506|Alcaligenaceae 28216|Betaproteobacteria IM Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis ispH - 1.17.7.4 ko:K03527 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05884,R08210 RC01137,RC01487 ko00000,ko00001,ko00002,ko01000 - - - LYTB k59_268096_1 1112204.GPOL_c46290 3.52e-13 75.9 COG0300@1|root,COG0596@1|root,COG0300@2|Bacteria,COG0596@2|Bacteria,2I2RM@201174|Actinobacteria,4GD5H@85026|Gordoniaceae 201174|Actinobacteria I Serine aminopeptidase, S33 ephD - - - - - - - - - - - Abhydrolase_1,adh_short k59_489755_1 1116472.MGMO_76c00010 1.29e-30 125.0 28HYC@1|root,2Z83T@2|Bacteria,1QEBM@1224|Proteobacteria,1RRCK@1236|Gammaproteobacteria,1XDJX@135618|Methylococcales 135618|Methylococcales - - - - - - - - - - - - - - - k59_268100_1 279238.Saro_1247 1.24e-180 511.0 COG0050@1|root,COG0050@2|Bacteria,1MVC0@1224|Proteobacteria,2TQP8@28211|Alphaproteobacteria,2K177@204457|Sphingomonadales 204457|Sphingomonadales J This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis tuf - - ko:K02358 - - - - ko00000,ko03012,ko03029,ko04147 - - - GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3 k59_1227050_1 748658.KB907313_gene2314 1.22e-52 179.0 COG0006@1|root,COG0006@2|Bacteria,1MUZS@1224|Proteobacteria,1RN0W@1236|Gammaproteobacteria,1WWJH@135613|Chromatiales 135613|Chromatiales E peptidase M24B, X-Pro dipeptidase aminopeptidase - - 3.4.11.9 ko:K01262 - - - - ko00000,ko01000,ko01002 - - - AMP_N,Peptidase_M24 k59_1227050_2 113355.CM001775_gene3777 0.000543 42.4 COG0654@1|root,COG0654@2|Bacteria,1FZY0@1117|Cyanobacteria 1117|Cyanobacteria CH TIGRFAM Ubiquinone biosynthesis hydroxylase, UbiH UbiF VisC COQ6 family ubiH - - ko:K03185 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00117 R04989,R08773 RC02670 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_3 k59_1622444_1 1122137.AQXF01000002_gene454 1.44e-93 282.0 COG0686@1|root,COG0686@2|Bacteria,1QTX1@1224|Proteobacteria,2TQQC@28211|Alphaproteobacteria 28211|Alphaproteobacteria C Belongs to the AlaDH PNT family ald - 1.4.1.1 ko:K00259 ko00250,ko00430,ko01100,map00250,map00430,map01100 - R00396 RC00008 ko00000,ko00001,ko01000 - - - AlaDh_PNT_C,AlaDh_PNT_N k59_1622444_2 1122137.AQXF01000002_gene455 2.62e-83 249.0 COG1522@1|root,COG1522@2|Bacteria,1RI7R@1224|Proteobacteria,2U9CC@28211|Alphaproteobacteria 28211|Alphaproteobacteria K transcriptional regulator dadR - - - - - - - - - - - AsnC_trans_reg,HTH_24,HTH_AsnC-type k59_1622444_3 288705.RSal33209_2828 0.000474 48.9 COG0708@1|root,COG0708@2|Bacteria,2IA3A@201174|Actinobacteria,1WANK@1268|Micrococcaceae 201174|Actinobacteria L Endonuclease/Exonuclease/phosphatase family - - - - - - - - - - - - Exo_endo_phos k59_1337200_1 95619.PM1_0200160 1.48e-67 218.0 COG0617@1|root,COG0617@2|Bacteria,1MU2X@1224|Proteobacteria,1RPFJ@1236|Gammaproteobacteria 1236|Gammaproteobacteria F Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. Also shows phosphatase, 2'- nucleotidase and 2',3'-cyclic phosphodiesterase activities. These phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases cca GO:0003674,GO:0003824,GO:0004652,GO:0004810,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0070566,GO:0071704,GO:0090304,GO:1901360,GO:1990817 2.7.7.72 ko:K00974 ko03013,map03013 - R09382,R09383,R09384,R09386 RC00078 ko00000,ko00001,ko01000,ko03016 - - - HD,PolyA_pol,PolyA_pol_RNAbd k59_489765_1 436308.Nmar_1223 4.87e-151 444.0 COG0464@1|root,arCOG01308@2157|Archaea,41S7X@651137|Thaumarchaeota 651137|Thaumarchaeota O Cell division protein 48 (CDC48) domain 2 - - - ko:K13525 ko04141,ko05134,map04141,map05134 M00400,M00403 - - ko00000,ko00001,ko00002,ko03019,ko04131,ko04147 3.A.16.1 - - AAA,CDC48_2,CDC48_N k59_489765_2 1229909.NSED_06855 6.4e-12 60.8 COG2092@1|root,arCOG01988@2157|Archaea,41SS1@651137|Thaumarchaeota 651137|Thaumarchaeota J Promotes the exchange of GDP for GTP in EF-1-alpha GDP, thus allowing the regeneration of EF-1-alpha GTP that could then be used to form the ternary complex EF-1-alpha GTP AAtRNA ef1b - - ko:K03232 - - - - ko00000,ko03012 - - - EF1_GNE k59_660301_1 1297742.A176_04040 6.82e-82 260.0 COG3486@1|root,COG3486@2|Bacteria,1MX36@1224|Proteobacteria,43DZI@68525|delta/epsilon subdivisions,2WZ9W@28221|Deltaproteobacteria,2Z1NT@29|Myxococcales 28221|Deltaproteobacteria C L-lysine 6-monooxygenase (NADPH-requiring) - - 1.14.13.59 ko:K03897 ko00310,ko01120,map00310,map01120 - R00448 RC00298 ko00000,ko00001,ko01000 - - - K_oxygenase k59_42884_1 158500.BV97_00256 3.17e-55 182.0 COG5126@1|root,COG5126@2|Bacteria,1NH5D@1224|Proteobacteria,2UNWA@28211|Alphaproteobacteria 28211|Alphaproteobacteria DTZ EF-hand, calcium binding motif - - - - - - - - - - - - EF-hand_5 k59_153097_1 95619.PM1_0204640 2.99e-50 178.0 COG1032@1|root,COG1032@2|Bacteria,1MUG3@1224|Proteobacteria,1RN9V@1236|Gammaproteobacteria 1236|Gammaproteobacteria C UPF0313 protein ygiQ - - - - - - - - - - - DUF3362,Radical_SAM,Radical_SAM_N k59_607781_1 1380394.JADL01000002_gene1281 4.34e-106 313.0 COG0491@1|root,COG0491@2|Bacteria,1MUT2@1224|Proteobacteria,2TRG9@28211|Alphaproteobacteria,2JQV5@204441|Rhodospirillales 204441|Rhodospirillales S Metallo-beta-lactamase superfamily - - - - - - - - - - - - Lactamase_B k59_98751_1 551275.KB899549_gene857 1.33e-13 77.8 COG1629@1|root,COG4771@2|Bacteria,1MWKN@1224|Proteobacteria,2TT5V@28211|Alphaproteobacteria 28211|Alphaproteobacteria P TonB-dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_1171059_1 1042377.AFPJ01000028_gene2158 4.82e-15 76.3 COG2755@1|root,COG2755@2|Bacteria,1MXTS@1224|Proteobacteria,1RTPH@1236|Gammaproteobacteria,46419@72275|Alteromonadaceae 1236|Gammaproteobacteria E Concanavalin A-like lectin/glucanases superfamily - - - - - - - - - - - - Laminin_G_3 k59_1171059_2 626887.J057_16740 8.82e-14 71.2 28HN6@1|root,2Z7WJ@2|Bacteria,1R5QB@1224|Proteobacteria,1RNJN@1236|Gammaproteobacteria,4667S@72275|Alteromonadaceae 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_997985_2 1168065.DOK_11164 9.43e-36 125.0 COG0691@1|root,COG0691@2|Bacteria,1RDFP@1224|Proteobacteria,1S3PT@1236|Gammaproteobacteria,1J68X@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene smpB GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0070930,GO:0071704,GO:0097159,GO:1901363,GO:1901564 - ko:K03664 - - - - ko00000 - - - SmpB k59_660330_1 396588.Tgr7_2138 4.45e-47 165.0 COG0795@1|root,COG0795@2|Bacteria,1MVW3@1224|Proteobacteria,1RM8H@1236|Gammaproteobacteria,1WWXY@135613|Chromatiales 135613|Chromatiales S Permease YjgP YjgQ - - - ko:K11720 ko02010,map02010 M00320 - - ko00000,ko00001,ko00002,ko02000 1.B.42.1 - - YjgP_YjgQ k59_1677366_2 592029.DDD_0481 3.32e-99 305.0 COG0365@1|root,COG0365@2|Bacteria,4NEAD@976|Bacteroidetes,1HYA0@117743|Flavobacteriia,3HJMI@363408|Nonlabens 976|Bacteroidetes I AMP-binding enzyme acsA - 6.2.1.1 ko:K01895 ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200 M00357 R00235,R00236,R00316,R00926,R01354 RC00004,RC00012,RC00043,RC00070,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000,ko01004 - - - ACAS_N,AMP-binding,AMP-binding_C k59_997996_1 715451.ambt_02245 1.6e-41 156.0 COG0653@1|root,COG0653@2|Bacteria,1MUJZ@1224|Proteobacteria,1RM9M@1236|Gammaproteobacteria,464S6@72275|Alteromonadaceae 1236|Gammaproteobacteria U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane secA GO:0000166,GO:0002790,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006457,GO:0006605,GO:0006810,GO:0006886,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0009306,GO:0009987,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032940,GO:0032991,GO:0033036,GO:0033220,GO:0034613,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042802,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0046903,GO:0046907,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0061077,GO:0065002,GO:0070727,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680 - ko:K03070 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4 - - SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW k59_1787363_2 1223544.GSI01S_04_00050 3.89e-32 125.0 COG4122@1|root,COG4122@2|Bacteria,2GJGI@201174|Actinobacteria,4GAZM@85026|Gordoniaceae 201174|Actinobacteria S Pup-ligase protein dop GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0006464,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0010498,GO:0016787,GO:0016810,GO:0016811,GO:0017076,GO:0018193,GO:0018205,GO:0019538,GO:0019941,GO:0030163,GO:0030554,GO:0032446,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0036211,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0051603,GO:0070490,GO:0070647,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575 3.5.1.119 ko:K20814 - - - - ko00000,ko01000,ko03051 - - - Pup_ligase k59_1399663_1 1156919.QWC_02589 3.85e-31 128.0 COG1529@1|root,COG1529@2|Bacteria,1QTTJ@1224|Proteobacteria,2VHII@28216|Betaproteobacteria,3T2EY@506|Alcaligenaceae 28216|Betaproteobacteria C Aldehyde dehydrogenase - - 1.3.99.16 ko:K00256 - - - - ko00000,ko01000 - - - Ald_Xan_dh_C,Ald_Xan_dh_C2 k59_544948_1 1121948.AUAC01000006_gene579 1.72e-16 79.3 COG4798@1|root,COG4798@2|Bacteria,1NNHX@1224|Proteobacteria,2U5HN@28211|Alphaproteobacteria,43XFZ@69657|Hyphomonadaceae 28211|Alphaproteobacteria S Methyltransferase - - - - - - - - - - - - - k59_544948_2 1122135.KB893146_gene1757 8.4e-17 75.1 COG1475@1|root,COG1475@2|Bacteria 2|Bacteria K chromosome segregation - - - ko:K03497 - - - - ko00000,ko03000,ko03036,ko04812 - - - ParBc k59_721112_1 377629.TERTU_1078 1.16e-75 254.0 COG1643@1|root,COG1643@2|Bacteria,1MUEQ@1224|Proteobacteria,1RMU1@1236|Gammaproteobacteria,2PNAT@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria L Helicase associated domain (HA2) Add an annotation hrpA GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0006139,GO:0006396,GO:0006397,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0034641,GO:0042623,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0070035,GO:0071704,GO:0090304,GO:0140098,GO:1901360 3.6.4.13 ko:K03578 - - - - ko00000,ko01000 - - - DEAD,DUF3418,HA2,Helicase_C,OB_NTP_bind k59_1171089_1 391615.ABSJ01000054_gene1377 2.06e-65 215.0 28H52@1|root,2Z7HQ@2|Bacteria,1MXTF@1224|Proteobacteria,1RN8H@1236|Gammaproteobacteria,1J8US@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Protein of unknown function (DUF1329) - - - - - - - - - - - - DUF1329 k59_1569922_2 502025.Hoch_2200 1.91e-43 150.0 COG0247@1|root,COG0247@2|Bacteria,1RF02@1224|Proteobacteria,43DRN@68525|delta/epsilon subdivisions,2WYQA@28221|Deltaproteobacteria,2Z0CV@29|Myxococcales 28221|Deltaproteobacteria C Protein of unknown function (DUF3501) - - - - - - - - - - - - DUF3501 k59_1569922_3 292415.Tbd_1107 1.98e-29 117.0 COG0247@1|root,COG0247@2|Bacteria,1MWTK@1224|Proteobacteria,2VJ6T@28216|Betaproteobacteria 28216|Betaproteobacteria C Cysteine-rich domain - - - - - - - - - - - - CCG,DUF3501 k59_998018_1 641491.DND132_2895 2.01e-06 48.5 COG0189@1|root,COG0189@2|Bacteria,1MX62@1224|Proteobacteria,42NIA@68525|delta/epsilon subdivisions,2WM87@28221|Deltaproteobacteria,2MGAY@213115|Desulfovibrionales 28221|Deltaproteobacteria F Prokaryotic glutathione synthetase, ATP-grasp domain rimK - 6.3.2.32 ko:K05844,ko:K14940 ko00680,ko01120,map00680,map01120 - R09401 RC00064,RC00090 ko00000,ko00001,ko01000,ko03009 - - - RimK k59_998018_2 1123247.AUIJ01000015_gene1377 1.79e-76 238.0 COG3608@1|root,COG3608@2|Bacteria,1MUAA@1224|Proteobacteria,2TRVI@28211|Alphaproteobacteria 28211|Alphaproteobacteria S succinylglutamate desuccinylase doeB - - ko:K06987 - - - - ko00000 - - - AstE_AspA k59_1280731_1 317655.Sala_1467 2.13e-09 57.8 COG3653@1|root,COG3653@2|Bacteria,1MWWY@1224|Proteobacteria,2TSZZ@28211|Alphaproteobacteria,2K1RR@204457|Sphingomonadales 204457|Sphingomonadales Q Amidohydrolase family - - 3.5.1.81 ko:K06015 - - R02192 RC00064,RC00328 ko00000,ko01000 - - - Amidohydro_3 k59_1280731_2 1122137.AQXF01000001_gene2746 1.31e-72 226.0 2D5F0@1|root,32TIY@2|Bacteria,1N1FC@1224|Proteobacteria,2UCTD@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_489815_1 519989.ECTPHS_13113 2.8e-46 151.0 COG0198@1|root,COG0198@2|Bacteria,1MZQD@1224|Proteobacteria,1S973@1236|Gammaproteobacteria,1WYKG@135613|Chromatiales 135613|Chromatiales J One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit rplX - - ko:K02895 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - KOW,ribosomal_L24 k59_544960_1 596154.Alide2_2447 7.75e-15 78.2 COG1752@1|root,COG1752@2|Bacteria,1MUM9@1224|Proteobacteria,2VK14@28216|Betaproteobacteria,4ACCJ@80864|Comamonadaceae 28216|Betaproteobacteria S PFAM Patatin - - - ko:K07001 - - - - ko00000 - - - Patatin k59_1337283_1 436308.Nmar_1647 2.22e-08 60.8 arCOG08812@1|root,arCOG08812@2157|Archaea,41T0K@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_891214_1 1150864.MILUP08_44290 0.000422 42.0 COG0346@1|root,COG0346@2|Bacteria,2IPQW@201174|Actinobacteria,4DM8J@85008|Micromonosporales 201174|Actinobacteria E Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - - - - - - - - - - Glyoxalase k59_891214_2 1445613.JALM01000068_gene5313 1.72e-38 143.0 COG3653@1|root,COG3653@2|Bacteria,2GKMK@201174|Actinobacteria,4DZQZ@85010|Pseudonocardiales 201174|Actinobacteria Q Amidohydrolase family - - 3.5.1.81 ko:K06015 - - R02192 RC00064,RC00328 ko00000,ko01000 - - - Amidohydro_3 k59_942138_1 1266925.JHVX01000009_gene37 3.42e-164 470.0 COG1066@1|root,COG1066@2|Bacteria,1MUJQ@1224|Proteobacteria,2VH93@28216|Betaproteobacteria,372GA@32003|Nitrosomonadales 28216|Betaproteobacteria O DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function radA - - ko:K04485 - - - - ko00000,ko03400 - - - AAA_25,ATPase,ChlI,Lon_C k59_607833_1 312153.Pnuc_0178 4.85e-49 176.0 COG1529@1|root,COG1529@2|Bacteria,1QTTJ@1224|Proteobacteria,2VHB9@28216|Betaproteobacteria,1JZMH@119060|Burkholderiaceae 28216|Betaproteobacteria C PFAM aldehyde oxidase and xanthine dehydrogenase molybdopterin binding - - 1.3.99.16 ko:K07303 - - - - ko00000,ko01000 - - - Ald_Xan_dh_C2 k59_1112085_1 314287.GB2207_08961 3.35e-48 164.0 COG0218@1|root,COG0218@2|Bacteria,1MY3Z@1224|Proteobacteria,1RNJP@1236|Gammaproteobacteria,1J5UE@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria D Necessary for normal cell division and for the maintenance of normal septation engB GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0017076,GO:0019001,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - ko:K03978 - - - - ko00000,ko03036 - - - MMR_HSR1 k59_382944_1 1111728.ATYS01000010_gene240 1.77e-92 290.0 COG0405@1|root,COG0405@2|Bacteria,1MUV6@1224|Proteobacteria,1RMIT@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Gamma-glutamyltransferase ggt GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0006082,GO:0006508,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0008242,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016787,GO:0019538,GO:0019752,GO:0030288,GO:0030313,GO:0031975,GO:0034722,GO:0036374,GO:0042597,GO:0043094,GO:0043102,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0070011,GO:0071704,GO:0097264,GO:0140096,GO:1901564,GO:1901566,GO:1901576 2.3.2.2,3.4.19.13 ko:K00681 ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100 - R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935 RC00064,RC00090,RC00096 ko00000,ko00001,ko01000,ko01002 - - iAPECO1_1312.APECO1_3012,iECOK1_1307.ECOK1_3869,iECS88_1305.ECS88_3844,iECW_1372.ECW_m3706,iEKO11_1354.EKO11_0296,iETEC_1333.ETEC_3693,iUMN146_1321.UM146_17325,iUTI89_1310.UTI89_C3954,iWFL_1372.ECW_m3706 G_glu_transpept k59_1060203_1 742159.HMPREF0004_5391 4.05e-54 189.0 COG1042@1|root,COG1042@2|Bacteria,1MW98@1224|Proteobacteria,2VI9R@28216|Betaproteobacteria,3T74P@506|Alcaligenaceae 28216|Betaproteobacteria C CoA binding domain - - - - - - - - - - - - ATP-grasp_5,Acetyltransf_1,Acetyltransf_3,Acetyltransf_4,CoA_binding_2,Succ_CoA_lig k59_1400782_1 1049564.TevJSym_aa01060 1.19e-35 132.0 COG2201@1|root,COG2201@2|Bacteria,1MWCN@1224|Proteobacteria,1RN67@1236|Gammaproteobacteria,1J5DG@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria NT catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR cheB - 3.1.1.61,3.5.1.44 ko:K03412 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko02022,ko02035 - - - CheB_methylest,Response_reg k59_154174_1 1415778.JQMM01000001_gene1922 2.14e-90 294.0 COG1197@1|root,COG1197@2|Bacteria,1MUXG@1224|Proteobacteria,1RNCU@1236|Gammaproteobacteria,1J4G0@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site mfd GO:0000715,GO:0000716,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006283,GO:0006289,GO:0006355,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008094,GO:0008150,GO:0008152,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0015616,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019219,GO:0019222,GO:0019899,GO:0031323,GO:0031326,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0043175,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0051276,GO:0051716,GO:0060255,GO:0065007,GO:0070063,GO:0071704,GO:0071840,GO:0080090,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1903506,GO:2000112,GO:2001141 - ko:K03723 ko03420,map03420 - - - ko00000,ko00001,ko01000,ko03400 - - - CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF k59_546067_1 1229909.NSED_01215 5.41e-13 68.9 COG0165@1|root,arCOG01748@2157|Archaea,41S6A@651137|Thaumarchaeota 651137|Thaumarchaeota E argininosuccinate lyase argH - 4.3.2.1 ko:K01755 ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230 M00029,M00844,M00845 R01086 RC00445,RC00447 ko00000,ko00001,ko00002,ko01000,ko04147 - - - ASL_C2,Lyase_1 k59_546067_2 1229909.NSED_05750 4.97e-20 86.3 arCOG05565@1|root,arCOG05565@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_1227954_1 1215092.PA6_012_00140 4.34e-67 215.0 COG1472@1|root,COG1472@2|Bacteria,1MVAJ@1224|Proteobacteria,1RMQF@1236|Gammaproteobacteria,1YEKF@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria G Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide-linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N-acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides nagZ GO:0000270,GO:0003674,GO:0003824,GO:0004553,GO:0004563,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006022,GO:0006807,GO:0008150,GO:0008152,GO:0009254,GO:0009273,GO:0009987,GO:0015929,GO:0016787,GO:0016798,GO:0030203,GO:0042546,GO:0043170,GO:0044085,GO:0044424,GO:0044444,GO:0044464,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901564 3.2.1.52 ko:K01207 ko00520,ko00531,ko01100,ko01501,map00520,map00531,map01100,map01501 M00628 R00022,R05963,R07809,R07810,R10831 RC00049 ko00000,ko00001,ko00002,ko01000 - - iSFV_1184.SFV_1127,iUMN146_1321.UM146_11790 Glyco_hydro_3 k59_1623442_1 1121918.ARWE01000001_gene3504 6.27e-86 269.0 COG0374@1|root,COG0374@2|Bacteria,1MWFJ@1224|Proteobacteria,42M4S@68525|delta/epsilon subdivisions,2WJQS@28221|Deltaproteobacteria,43TIF@69541|Desulfuromonadales 28221|Deltaproteobacteria C Nickel-dependent hydrogenase hyaL - 1.12.99.6 ko:K06281 ko00633,ko01120,map00633,map01120 - R08034 RC00250 ko00000,ko00001,ko01000 - - - NiFeSe_Hases k59_99687_1 1175306.GWL_24360 6.14e-19 89.0 COG0614@1|root,COG0614@2|Bacteria,1MWVF@1224|Proteobacteria,2VJ7T@28216|Betaproteobacteria,473JS@75682|Oxalobacteraceae 28216|Betaproteobacteria P Periplasmic binding protein btuF - - ko:K02016,ko:K06858 ko02010,map02010 M00240,M00241 - - ko00000,ko00001,ko00002,ko02000 3.A.1.13,3.A.1.14 - - Peripla_BP_2 k59_1749527_1 1229909.NSED_01260 2.27e-26 107.0 COG4799@1|root,arCOG02705@2157|Archaea,41SEH@651137|Thaumarchaeota 651137|Thaumarchaeota I Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) - - 2.1.3.15,6.4.1.2,6.4.1.3 ko:K18604 ko00720,ko01120,map00720,map01120 - R00742,R01859 RC00040,RC00097,RC00367,RC00609 ko00000,ko00001,ko01000 - - - Carboxyl_trans k59_1295959_2 1120953.AUBH01000010_gene146 3.39e-71 219.0 2DJ8V@1|root,3050U@2|Bacteria,1RE7U@1224|Proteobacteria,1SNMT@1236|Gammaproteobacteria,46ATK@72275|Alteromonadaceae 1236|Gammaproteobacteria - - - - - ko:K10716 - - - - ko00000,ko02000 1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6 - - - k59_448646_1 519989.ECTPHS_03227 2.36e-19 88.2 COG0115@1|root,COG0115@2|Bacteria,1MZAK@1224|Proteobacteria,1RPPG@1236|Gammaproteobacteria,1WXUQ@135613|Chromatiales 135613|Chromatiales EH PFAM Aminotransferase, class IV - - 4.1.3.38 ko:K02619 ko00790,map00790 - R05553 RC01843,RC02148 ko00000,ko00001,ko01000 - - - Aminotran_4 k59_448646_2 1146883.BLASA_2275 3.2e-08 55.5 COG0147@1|root,COG0147@2|Bacteria,2GKJT@201174|Actinobacteria,4ERKC@85013|Frankiales 201174|Actinobacteria E Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia trpE - 4.1.3.27 ko:K01657 ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025 M00023 R00985,R00986 RC00010,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 - - - Anth_synt_I_N,Chorismate_bind k59_1012278_1 59538.XP_005973557.1 4.83e-13 68.9 COG0768@1|root,2QR8J@2759|Eukaryota,39SBS@33154|Opisthokonta,3BIR4@33208|Metazoa,3DFVW@33213|Bilateria 33208|Metazoa M Penicillin-binding Protein dimerisation domain - - - - - - - - - - - - FTSW_RODA_SPOVE,PBP_dimer,SPOUT_MTase,Transpeptidase k59_1012278_2 981383.AEWH01000068_gene286 3.89e-42 145.0 COG2003@1|root,COG2003@2|Bacteria,1TQ3K@1239|Firmicutes,4HB1W@91061|Bacilli 91061|Bacilli E Belongs to the UPF0758 family radC - - ko:K03630 - - - - ko00000 - - - RadC k59_1295970_1 1305732.JAGG01000001_gene1662 1.04e-28 119.0 COG4581@1|root,COG4581@2|Bacteria,2GJEX@201174|Actinobacteria,4FKRU@85023|Microbacteriaceae 201174|Actinobacteria L DSHCT helY GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009056,GO:0009057,GO:0009987,GO:0016020,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019439,GO:0030312,GO:0034641,GO:0034655,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0070035,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:1901360,GO:1901361,GO:1901575 - ko:K03727 - - - - ko00000,ko01000 - - - DEAD,DSHCT,Helicase_C,rRNA_proc-arch k59_1012290_1 880072.Desac_0689 1.9e-157 466.0 COG1154@1|root,COG1154@2|Bacteria,1MUSJ@1224|Proteobacteria,42M35@68525|delta/epsilon subdivisions,2WIX5@28221|Deltaproteobacteria,2MQAA@213462|Syntrophobacterales 28221|Deltaproteobacteria H Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) dxs - 2.2.1.7 ko:K01662 ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130 M00096 R05636 RC00032 ko00000,ko00001,ko00002,ko01000 - - - DXP_synthase_N,Transket_pyr,Transketolase_C k59_225119_1 357808.RoseRS_2164 2.11e-07 59.7 COG1752@1|root,COG1752@2|Bacteria,2G7GM@200795|Chloroflexi,374ZF@32061|Chloroflexia 32061|Chloroflexia S PFAM Patatin - - - - - - - - - - - - Patatin k59_1637354_1 935840.JAEQ01000004_gene346 2.09e-80 241.0 COG1917@1|root,COG1917@2|Bacteria,1MUY3@1224|Proteobacteria,2U5R0@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Cupin 2, conserved barrel - - 1.13.11.41 ko:K05913 ko00363,ko01120,map00363,map01120 - R01305 RC00415,RC01565 ko00000,ko00001,ko01000 - - - Cupin_2 k59_1637358_1 215803.DB30_5526 2.53e-20 94.7 COG2885@1|root,COG2885@2|Bacteria,1R4WG@1224|Proteobacteria,42TD5@68525|delta/epsilon subdivisions,2WP3U@28221|Deltaproteobacteria,2YZG5@29|Myxococcales 28221|Deltaproteobacteria M OmpA family - - - ko:K03286 - - - - ko00000,ko02000 1.B.6 - - DUF5011,HYR,OMP_b-brl,OmpA,TSP_3 k59_1749570_1 1297863.APJF01000006_gene1247 6.5e-56 202.0 COG2114@1|root,COG3899@1|root,COG2114@2|Bacteria,COG3899@2|Bacteria,1MUDT@1224|Proteobacteria,2TQVN@28211|Alphaproteobacteria,3JTQ7@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria T Adenylate and Guanylate cyclase catalytic domain - - 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 - - - AAA_16,Abhydrolase_1,DZR,Guanylate_cyc,TPR_4 k59_674826_2 1246995.AFR_07945 2.45e-14 68.6 COG0537@1|root,COG0537@2|Bacteria,2IHPT@201174|Actinobacteria,4DEAE@85008|Micromonosporales 201174|Actinobacteria FG Histidine triad (HIT) protein hit - - ko:K02503 - - - - ko00000,ko04147 - - - DcpS_C,HIT k59_1185292_2 614083.AWQR01000009_gene733 1.96e-27 113.0 COG2114@1|root,COG4252@1|root,COG2114@2|Bacteria,COG4252@2|Bacteria,1MV1V@1224|Proteobacteria,2VJ72@28216|Betaproteobacteria,4ABWU@80864|Comamonadaceae 28216|Betaproteobacteria T Adenylate cyclase cyaA - 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 - - - CHASE2,Guanylate_cyc k59_1465593_1 316407.85676883 2.71e-161 462.0 COG3104@1|root,COG3104@2|Bacteria,1MW6W@1224|Proteobacteria,1RM8P@1236|Gammaproteobacteria,3XN0T@561|Escherichia 1236|Gammaproteobacteria E Proton-dependent permease that transports di- and tripeptides. Shows significantly higher specificity towards dipeptides than tripeptides. Has a preference for dipeptides with a C-terminal Lys residue. Can bind Ala-Lys, Lys-Ala, Ala-Ala. Can also transport alanine and trialanine yjdL GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006857,GO:0008150,GO:0008324,GO:0015075,GO:0015077,GO:0015078,GO:0015291,GO:0015293,GO:0015294,GO:0015295,GO:0015318,GO:0015333,GO:0015672,GO:0015833,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0022890,GO:0031224,GO:0034220,GO:0035442,GO:0035443,GO:0035672,GO:0035673,GO:0042886,GO:0042887,GO:0042937,GO:0042938,GO:0042939,GO:0044425,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071916,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:1902600,GO:1904680 - ko:K03305 - - - - ko00000 2.A.17 - iECO103_1326.ECO103_0702,iEcSMS35_1347.EcSMS35_4599 PTR2 k59_674828_1 73044.JNXP01000002_gene2119 1.25e-17 85.1 COG0364@1|root,COG0364@2|Bacteria,2GISI@201174|Actinobacteria 201174|Actinobacteria G Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone zwf1 GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 1.1.1.363,1.1.1.49 ko:K00036 ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230 M00004,M00006,M00008 R00835,R02736,R10907 RC00001,RC00066 ko00000,ko00001,ko00002,ko01000,ko04147 - - - G6PD_C,G6PD_N k59_674828_2 366394.Smed_5761 0.000377 45.1 COG2114@1|root,COG2267@1|root,COG2114@2|Bacteria,COG2267@2|Bacteria,1QU5X@1224|Proteobacteria,2TW12@28211|Alphaproteobacteria 28211|Alphaproteobacteria T Adenylate and Guanylate cyclase catalytic domain - - - - - - - - - - - - Abhydrolase_1,Guanylate_cyc k59_1692797_1 158500.BV97_00659 1.3e-37 139.0 COG1233@1|root,COG1233@2|Bacteria,1MV2R@1224|Proteobacteria,2TSR0@28211|Alphaproteobacteria,2JZXX@204457|Sphingomonadales 204457|Sphingomonadales Q Oxidoreductase - - - - - - - - - - - - Amino_oxidase,NAD_binding_8 k59_786393_1 566466.NOR53_537 8.56e-41 145.0 COG2124@1|root,COG2124@2|Bacteria,1MV8Q@1224|Proteobacteria,1RPW8@1236|Gammaproteobacteria,1J9N7@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Cytochrome P450 ahpG - - - - - - - - - - - p450 k59_786393_2 999141.GME_09741 2.7e-22 94.7 COG0583@1|root,COG0583@2|Bacteria,1MWVU@1224|Proteobacteria,1RPT8@1236|Gammaproteobacteria,1XIGK@135619|Oceanospirillales 135619|Oceanospirillales K transcriptional regulator - - - - - - - - - - - - HTH_1,LysR_substrate k59_674853_1 582899.Hden_0031 7.31e-30 114.0 29525@1|root,2ZSEY@2|Bacteria,1RF0P@1224|Proteobacteria,2U90Q@28211|Alphaproteobacteria,3N8GN@45401|Hyphomicrobiaceae 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_674853_2 1129794.C427_2841 1.05e-30 117.0 COG3339@1|root,COG3339@2|Bacteria,1RAN7@1224|Proteobacteria,1S291@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Conserved Protein - - - - - - - - - - - - DUF1232 k59_225169_1 876044.IMCC3088_1279 1.3e-216 613.0 COG0033@1|root,COG0033@2|Bacteria,1MU5S@1224|Proteobacteria,1RPDV@1236|Gammaproteobacteria 1236|Gammaproteobacteria G Phosphoglucomutase pgm - 5.4.2.2 ko:K01835 ko00010,ko00030,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130 M00549 R00959,R01057,R08639 RC00408 ko00000,ko00001,ko00002,ko01000 - - - PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV k59_1296018_1 1209072.ALBT01000033_gene1729 5.12e-73 239.0 COG0171@1|root,COG0388@1|root,COG0171@2|Bacteria,COG0388@2|Bacteria,1MU9U@1224|Proteobacteria,1RNKA@1236|Gammaproteobacteria,1FGTG@10|Cellvibrio 1236|Gammaproteobacteria H Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source nadE - 6.3.1.5,6.3.5.1 ko:K01916,ko:K01950 ko00760,ko01100,map00760,map01100 M00115 R00189,R00257 RC00010,RC00100 ko00000,ko00001,ko00002,ko01000 - - - CN_hydrolase,NAD_synthase k59_559869_1 1380391.JIAS01000014_gene2273 3.79e-28 106.0 COG1522@1|root,COG1522@2|Bacteria,1MXVU@1224|Proteobacteria,2TTCK@28211|Alphaproteobacteria,2JRIB@204441|Rhodospirillales 204441|Rhodospirillales K COG1522 Transcriptional regulators - - - - - - - - - - - - AsnC_trans_reg,HTH_24 k59_559869_2 1123355.JHYO01000035_gene576 3.22e-38 132.0 COG0782@1|root,COG0782@2|Bacteria,1RCXW@1224|Proteobacteria,2U5JU@28211|Alphaproteobacteria,36Y10@31993|Methylocystaceae 28211|Alphaproteobacteria K Transcription elongation factor, N-terminal greA - - ko:K03624 - - - - ko00000,ko03021 - - - GreA_GreB,GreA_GreB_N k59_674862_1 1265503.KB905171_gene535 2.21e-28 118.0 COG1502@1|root,COG1502@2|Bacteria,1MUDJ@1224|Proteobacteria,1RMIF@1236|Gammaproteobacteria,2Q7IA@267889|Colwelliaceae 1236|Gammaproteobacteria I Phospholipase D. Active site motifs. clsC GO:0003674,GO:0003824,GO:0005575,GO:0006629,GO:0006644,GO:0006650,GO:0006655,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0008808,GO:0009058,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016780,GO:0019637,GO:0030572,GO:0032048,GO:0032049,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0045017,GO:0046471,GO:0046474,GO:0046486,GO:0071704,GO:0090407,GO:0090483,GO:1901576 - ko:K06132 ko00564,ko01100,map00564,map01100 - R11062 RC00017 ko00000,ko00001,ko01000 - - - PLDc_2 k59_503931_1 479434.Sthe_1402 1.65e-34 134.0 COG3552@1|root,COG3552@2|Bacteria,2G5IW@200795|Chloroflexi,27XNE@189775|Thermomicrobia 189775|Thermomicrobia S VWA domain containing CoxE-like protein - - - ko:K07161 - - - - ko00000 - - - VWA_CoxE k59_1241384_1 586413.CCDL010000001_gene1495 3.82e-25 103.0 COG1738@1|root,COG1738@2|Bacteria,1TSAY@1239|Firmicutes,4HB9T@91061|Bacilli,23JTA@182709|Oceanobacillus 91061|Bacilli S Involved in the import of queuosine (Q) precursors, required for Q precursor salvage yhhQ_2 - - ko:K09125 - - - - ko00000 - - - Vut_1 k59_1352011_1 1131266.ARWQ01000009_gene940 3e-34 131.0 COG0704@1|root,arCOG00318@2157|Archaea,41SC5@651137|Thaumarchaeota 651137|Thaumarchaeota K Phosphate uptake regulator - - - - - - - - - - - - MazE_antitoxin,PhoU k59_1352013_1 1122137.AQXF01000001_gene3210 1.64e-111 333.0 COG1004@1|root,COG1004@2|Bacteria,1MW5U@1224|Proteobacteria,2TREV@28211|Alphaproteobacteria 28211|Alphaproteobacteria M Belongs to the UDP-glucose GDP-mannose dehydrogenase family rkpK GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 1.1.1.22 ko:K00012 ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100 M00014,M00129,M00361,M00362 R00286 RC00291 ko00000,ko00001,ko00002,ko01000 - - - UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N k59_1185324_1 450851.PHZ_c3216 6.25e-100 297.0 COG1028@1|root,COG1028@2|Bacteria,1MVYJ@1224|Proteobacteria,2TRJ8@28211|Alphaproteobacteria,2KHYZ@204458|Caulobacterales 204458|Caulobacterales IQ KR domain - - - - - - - - - - - - adh_short_C2 k59_1012356_1 570967.JMLV01000002_gene1806 1.21e-06 50.1 COG0604@1|root,COG0604@2|Bacteria,1MWBD@1224|Proteobacteria,2TS3Z@28211|Alphaproteobacteria,2JQBK@204441|Rhodospirillales 204441|Rhodospirillales C COG0604 NADPH quinone reductase and related Zn-dependent oxidoreductases - - 1.6.5.5 ko:K00344 - - - - ko00000,ko01000 - - - ADH_N,ADH_zinc_N k59_1749631_1 323848.Nmul_A1150 2.76e-98 315.0 COG0493@1|root,COG0543@1|root,COG0493@2|Bacteria,COG0543@2|Bacteria,1PV5D@1224|Proteobacteria,2WB3J@28216|Betaproteobacteria,37281@32003|Nitrosomonadales 28216|Betaproteobacteria CEH PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase - - - - - - - - - - - - Pyr_redox_2 k59_1126884_1 555778.Hneap_0401 5.43e-10 62.4 COG2027@1|root,COG2027@2|Bacteria,1MW40@1224|Proteobacteria,1RP8V@1236|Gammaproteobacteria,1WWVE@135613|Chromatiales 135613|Chromatiales M PFAM Peptidase S13, D-Ala-D-Ala carboxypeptidase C - - 3.4.16.4 ko:K07259 ko00550,map00550 - - - ko00000,ko00001,ko01000,ko01002,ko01011 - - - Peptidase_S13 k59_1692874_1 1121456.ATVA01000014_gene598 5.06e-36 141.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,42M0W@68525|delta/epsilon subdivisions,2WIK8@28221|Deltaproteobacteria,2M8CQ@213115|Desulfovibrionales 28221|Deltaproteobacteria T Diguanylate cyclase phosphodiesterase with PAS PAC sensor(S) - - - ko:K03320 - - - - ko00000,ko02000 1.A.11 - - Ammonium_transp,EAL,GGDEF,PAS,PAS_4,PAS_9 k59_1126885_1 469383.Cwoe_2515 1.39e-73 249.0 COG1190@1|root,COG2898@1|root,COG1190@2|Bacteria,COG2898@2|Bacteria,2GKE0@201174|Actinobacteria 201174|Actinobacteria J Belongs to the class-II aminoacyl-tRNA synthetase family - - 6.1.1.6 ko:K04567 ko00970,map00970 M00359,M00360 R03658 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DUF2156,tRNA-synt_2,tRNA_anti-codon k59_448737_1 1453501.JELR01000001_gene2684 2.41e-107 320.0 COG0412@1|root,COG0412@2|Bacteria,1NRB4@1224|Proteobacteria,1SBI0@1236|Gammaproteobacteria 1236|Gammaproteobacteria Q Dienelactone hydrolase - - 3.1.1.45 ko:K01061 ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130 - R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222 RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686 ko00000,ko00001,ko01000 - - - DLH k59_1126888_1 1229909.NSED_05420 5.58e-30 117.0 COG0574@1|root,arCOG01111@2157|Archaea,41SYV@651137|Thaumarchaeota 651137|Thaumarchaeota G Pyruvate phosphate dikinase - - 2.7.9.1 ko:K01006 ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200 M00169,M00171,M00172,M00173 R00206 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000 - - - PEP-utilizers,PEP-utilizers_C,PPDK_N k59_1126888_2 1365176.N186_05840 2.97e-05 45.8 COG0149@1|root,arCOG01087@2157|Archaea,2XPYA@28889|Crenarchaeota 28889|Crenarchaeota G Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P) tpiA GO:0003674,GO:0003824,GO:0004807,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006066,GO:0006071,GO:0006081,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0018130,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019400,GO:0019405,GO:0019438,GO:0019439,GO:0019563,GO:0019637,GO:0019682,GO:0019693,GO:0019751,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044262,GO:0044270,GO:0044271,GO:0044275,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046164,GO:0046166,GO:0046174,GO:0046184,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1901615,GO:1901616 5.3.1.1 ko:K01803 ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003 R01015 RC00423 ko00000,ko00001,ko00002,ko01000,ko04147 - - - TIM,ThiG k59_674905_1 883126.HMPREF9710_02388 9.1e-88 270.0 COG0282@1|root,COG0282@2|Bacteria,1MW61@1224|Proteobacteria,2VHRC@28216|Betaproteobacteria,4739A@75682|Oxalobacteraceae 28216|Betaproteobacteria F Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction ackA - 2.7.2.1 ko:K00925 ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200 M00357,M00579 R00315,R01353 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - Acetate_kinase k59_1352049_2 1117647.M5M_04610 5.48e-64 204.0 COG0811@1|root,COG0811@2|Bacteria,1NXZ9@1224|Proteobacteria,1S154@1236|Gammaproteobacteria,1J4YC@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria U COG0811 Biopolymer transport proteins - - - - - - - - - - - - MotA_ExbB k59_225217_1 395494.Galf_2236 2.48e-82 254.0 COG1076@1|root,COG1076@2|Bacteria,1N270@1224|Proteobacteria,2VJ6J@28216|Betaproteobacteria,44W9Z@713636|Nitrosomonadales 28216|Betaproteobacteria O SMART heat shock protein DnaJ domain protein - - - ko:K05801 - - - - ko00000,ko03110 - - - DnaJ,TerB k59_958936_1 1122137.AQXF01000002_gene403 1.44e-83 257.0 COG1652@1|root,COG1652@2|Bacteria,1MWMR@1224|Proteobacteria,2U7UH@28211|Alphaproteobacteria 28211|Alphaproteobacteria M protein containing LysM domain lysM - - - - - - - - - - - LysM k59_561912_1 977880.RALTA_A1787 3.63e-49 161.0 COG2193@1|root,COG2193@2|Bacteria,1RAQ8@1224|Proteobacteria,2VQHR@28216|Betaproteobacteria,1K074@119060|Burkholderiaceae 28216|Betaproteobacteria P Ferritin, Dps family protein bfr3 - 1.16.3.1 ko:K03594 ko00860,map00860 - R00078 RC02758 ko00000,ko00001,ko01000 - - - Ferritin k59_561912_2 1177154.Y5S_02944 2.31e-18 90.9 COG1160@1|root,COG1160@2|Bacteria,1QU8G@1224|Proteobacteria,1T3BC@1236|Gammaproteobacteria,1XIS4@135619|Oceanospirillales 135619|Oceanospirillales S Domain of unknown function (DUF3482) - - - - - - - - - - - - DUF3482,MMR_HSR1 k59_958947_1 1178825.ALIH01000012_gene1785 3.34e-59 187.0 COG3279@1|root,COG3279@2|Bacteria,4NFN4@976|Bacteroidetes,1HYAZ@117743|Flavobacteriia 976|Bacteroidetes KT Response regulator of the LytR AlgR family - - - - - - - - - - - - LytTR,Response_reg k59_676910_2 472759.Nhal_0548 3.71e-121 363.0 COG0312@1|root,COG0312@2|Bacteria,1MUSK@1224|Proteobacteria,1RMA5@1236|Gammaproteobacteria,1WWCQ@135613|Chromatiales 135613|Chromatiales S modulator of DNA gyrase tldD - - ko:K03568 - - - - ko00000,ko01002 - - - PmbA_TldD k59_1694749_2 2340.JV46_07500 1.17e-48 163.0 COG2834@1|root,COG2834@2|Bacteria,1MXW0@1224|Proteobacteria,1RS0K@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Outer membrane lipoprotein-sorting protein VP1287 - - - - - - - - - - - LolA_like k59_1694749_3 2340.JV46_07500 4.43e-16 77.0 COG2834@1|root,COG2834@2|Bacteria,1MXW0@1224|Proteobacteria,1RS0K@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Outer membrane lipoprotein-sorting protein VP1287 - - - - - - - - - - - LolA_like k59_1353998_1 1268622.AVS7_01343 7.18e-57 188.0 COG0500@1|root,COG0500@2|Bacteria,1QU8V@1224|Proteobacteria,2WGJ7@28216|Betaproteobacteria,4AHEN@80864|Comamonadaceae 28216|Betaproteobacteria Q Histone methylation protein DOT1 - - - - - - - - - - - - Methyltransf_25,Methyltransf_31 k59_561915_1 697282.Mettu_2378 2.49e-20 91.7 COG0810@1|root,COG0810@2|Bacteria,1PEDH@1224|Proteobacteria,1RRNT@1236|Gammaproteobacteria,1XFS3@135618|Methylococcales 135618|Methylococcales U Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins - - - - - - - - - - - - TonB_C k59_561915_2 1220535.IMCC14465_01190 1.37e-49 181.0 COG0457@1|root,COG0457@2|Bacteria,1MVCA@1224|Proteobacteria,2UAC1@28211|Alphaproteobacteria 28211|Alphaproteobacteria S COG0457 FOG TPR repeat - - - - - - - - - - - - TPR_16,TPR_7,TPR_8 k59_561915_3 1435356.Y013_23890 3.45e-22 108.0 COG1014@1|root,COG4231@1|root,COG1014@2|Bacteria,COG4231@2|Bacteria,2GKBW@201174|Actinobacteria,4FUYI@85025|Nocardiaceae 201174|Actinobacteria C ferredoxin, Oxidoreductase - - 1.2.7.8 ko:K00179,ko:K04090 - - - - br01601,ko00000,ko01000 - - - Fer4,POR,POR_N,TPP_enzyme_C k59_1354002_1 1205753.A989_16318 1.09e-15 77.8 COG0654@1|root,COG0654@2|Bacteria,1R7UC@1224|Proteobacteria,1S1B9@1236|Gammaproteobacteria,1X3BJ@135614|Xanthomonadales 135614|Xanthomonadales H Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid kmo GO:0003674,GO:0003824,GO:0004497,GO:0008150,GO:0008152,GO:0009058,GO:0016491,GO:0019748,GO:0044550,GO:0055114 1.14.13.9 ko:K00486 ko00380,ko01100,map00380,map01100 M00038 R01960 RC00046 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_3 k59_1354002_2 666685.R2APBS1_1216 1.27e-87 272.0 COG3844@1|root,COG3844@2|Bacteria,1MUKN@1224|Proteobacteria,1RPY3@1236|Gammaproteobacteria,1X3FQ@135614|Xanthomonadales 135614|Xanthomonadales E Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively kynU GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006568,GO:0006569,GO:0006576,GO:0006586,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009072,GO:0009074,GO:0009308,GO:0009310,GO:0009987,GO:0016054,GO:0016787,GO:0016822,GO:0016823,GO:0019439,GO:0019441,GO:0019752,GO:0030429,GO:0032787,GO:0034641,GO:0042180,GO:0042402,GO:0042430,GO:0042436,GO:0042537,GO:0043420,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0044424,GO:0044464,GO:0046218,GO:0046395,GO:0046483,GO:0046700,GO:0070189,GO:0071704,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 3.7.1.3 ko:K01556 ko00380,ko01100,map00380,map01100 M00038 R00987,R02668,R03936 RC00284,RC00415 ko00000,ko00001,ko00002,ko01000 - - - Aminotran_5 k59_505955_1 748247.AZKH_3221 1.29e-59 207.0 COG2217@1|root,COG2608@1|root,COG2217@2|Bacteria,COG2608@2|Bacteria,1MU08@1224|Proteobacteria,2VJSM@28216|Betaproteobacteria,2KV1V@206389|Rhodocyclales 206389|Rhodocyclales P cation transport ATPase ccoI - 3.6.3.4 ko:K01533 - - R00086 RC00002 ko00000,ko01000 3.A.3.5 - - ATPase-cat_bd,E1-E2_ATPase,HMA,Hydrolase k59_450753_1 1453501.JELR01000001_gene3254 1.06e-41 145.0 COG3483@1|root,COG3483@2|Bacteria,1MW68@1224|Proteobacteria,1RXYM@1236|Gammaproteobacteria,4669G@72275|Alteromonadaceae 1236|Gammaproteobacteria E Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety kynA GO:0003674,GO:0003824,GO:0004833,GO:0005488,GO:0006082,GO:0006084,GO:0006139,GO:0006163,GO:0006520,GO:0006568,GO:0006569,GO:0006576,GO:0006586,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009072,GO:0009074,GO:0009117,GO:0009150,GO:0009259,GO:0009308,GO:0009310,GO:0009987,GO:0016043,GO:0016054,GO:0016491,GO:0016701,GO:0016702,GO:0019439,GO:0019441,GO:0019442,GO:0019637,GO:0019693,GO:0019752,GO:0020037,GO:0022607,GO:0033865,GO:0033875,GO:0034032,GO:0034641,GO:0035383,GO:0042180,GO:0042402,GO:0042430,GO:0042436,GO:0042537,GO:0043436,GO:0043603,GO:0043933,GO:0044085,GO:0044106,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0046218,GO:0046395,GO:0046483,GO:0046700,GO:0046906,GO:0048037,GO:0051186,GO:0051213,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055086,GO:0055114,GO:0065003,GO:0070189,GO:0071704,GO:0071840,GO:0072521,GO:0097159,GO:1901135,GO:1901360,GO:1901361,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 1.13.11.11 ko:K00453 ko00380,ko01100,map00380,map01100 M00038 R00678 RC00356 ko00000,ko00001,ko00002,ko01000 - - - Trp_dioxygenase k59_450753_2 208439.AJAP_30680 2.93e-21 92.0 COG0520@1|root,COG0520@2|Bacteria,2GN15@201174|Actinobacteria,4E19E@85010|Pseudonocardiales 201174|Actinobacteria E Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine - - - - - - - - - - - - Aminotran_5 k59_505962_1 1484460.JSWG01000001_gene2240 1.86e-09 68.6 COG1538@1|root,COG2984@1|root,COG1538@2|Bacteria,COG2984@2|Bacteria,4NHGK@976|Bacteroidetes,1HX6D@117743|Flavobacteriia 976|Bacteroidetes MU Outer membrane efflux protein - - - - - - - - - - - - ABC_sub_bind,OEP k59_1694772_1 349106.PsycPRwf_0005 2.31e-108 341.0 COG0187@1|root,COG0187@2|Bacteria,1MVKT@1224|Proteobacteria,1RNB2@1236|Gammaproteobacteria,3NJZQ@468|Moraxellaceae 1236|Gammaproteobacteria L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrB GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003916,GO:0003918,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006265,GO:0006351,GO:0006725,GO:0006807,GO:0006996,GO:0007059,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009295,GO:0009330,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017076,GO:0017111,GO:0018130,GO:0019438,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032774,GO:0032991,GO:0034335,GO:0034641,GO:0034645,GO:0034654,GO:0035639,GO:0036094,GO:0042221,GO:0042493,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051276,GO:0061505,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0097367,GO:0097659,GO:0140097,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901576 5.99.1.3 ko:K02470 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim k59_1694780_1 1283300.ATXB01000001_gene1641 4.03e-06 48.5 COG0053@1|root,COG0053@2|Bacteria,1MVH8@1224|Proteobacteria,1RQ3E@1236|Gammaproteobacteria,1XEIQ@135618|Methylococcales 135618|Methylococcales P Cation efflux family - - - - - - - - - - - - Cation_efflux k59_561941_2 1304872.JAGC01000009_gene1461 1e-12 71.6 COG0725@1|root,COG0725@2|Bacteria,1MVNA@1224|Proteobacteria,435M4@68525|delta/epsilon subdivisions,2WZZW@28221|Deltaproteobacteria,2M98G@213115|Desulfovibrionales 28221|Deltaproteobacteria P molybdenum ABC transporter, periplasmic - - - ko:K02020 ko02010,map02010 M00189 - - ko00000,ko00001,ko00002,ko02000 3.A.1.8 - - SBP_bac_11 k59_1354027_1 204669.Acid345_3938 4.47e-42 147.0 COG1208@1|root,COG1208@2|Bacteria,3Y4HJ@57723|Acidobacteria 57723|Acidobacteria JM Nucleotidyl transferase - - - - - - - - - - - - NTP_transf_3,NTP_transferase k59_1694792_1 1229909.NSED_00850 3.63e-68 214.0 arCOG08023@1|root,arCOG08023@2157|Archaea,41SKK@651137|Thaumarchaeota 651137|Thaumarchaeota S Zinc finger domain - - - - - - - - - - - - zinc_ribbon_2 k59_1467687_1 767029.HMPREF9154_1988 1.09e-23 103.0 COG0209@1|root,COG0209@2|Bacteria,2GKX9@201174|Actinobacteria,4DP4H@85009|Propionibacteriales 201174|Actinobacteria F Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen nrdJ GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0016020,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - Ribonuc_red_2_N,Ribonuc_red_lgC k59_1467687_3 1541959.KQ51_01703 2.63e-11 62.8 COG2304@1|root,COG2304@2|Bacteria 2|Bacteria IU oxidoreductase activity - - - - - - - - - - - - VWA k59_959009_1 1535422.ND16A_2096 2.93e-52 187.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,2Q6H5@267889|Colwelliaceae 1236|Gammaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_676967_1 1175306.GWL_22280 4.35e-46 155.0 COG1028@1|root,COG1028@2|Bacteria,1MWJI@1224|Proteobacteria,2VHU1@28216|Betaproteobacteria,473UI@75682|Oxalobacteraceae 28216|Betaproteobacteria IQ Short chain dehydrogenase - - 1.1.1.100 ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 k59_676967_2 398578.Daci_3618 4.69e-11 63.5 COG0840@1|root,COG4564@1|root,COG0840@2|Bacteria,COG4564@2|Bacteria,1MU9B@1224|Proteobacteria,2VITJ@28216|Betaproteobacteria,4AA3T@80864|Comamonadaceae 28216|Betaproteobacteria NT chemotaxis - - - - - - - - - - - - HAMP,MCPsignal,sCache_2 k59_1694804_1 240016.ABIZ01000001_gene292 2.16e-62 220.0 COG0265@1|root,COG0823@1|root,COG2234@1|root,COG0265@2|Bacteria,COG0823@2|Bacteria,COG2234@2|Bacteria,46T85@74201|Verrucomicrobia 74201|Verrucomicrobia OU PA domain - - - - - - - - - - - - PA,PD40,PDZ_2,Peptidase_M28 k59_676976_1 702113.PP1Y_AT7242 2.3e-75 247.0 COG2307@1|root,COG2308@1|root,COG2307@2|Bacteria,COG2308@2|Bacteria,1MX5P@1224|Proteobacteria,2TRJE@28211|Alphaproteobacteria,2JZVX@204457|Sphingomonadales 204457|Sphingomonadales S Circularly permuted ATP-grasp type 2 - - - - - - - - - - - - Alpha-E,CP_ATPgrasp_2 k59_1467716_1 1236541.BALL01000044_gene4027 7.88e-44 154.0 2CJ6B@1|root,32S9B@2|Bacteria,1N2I4@1224|Proteobacteria,1S8Z8@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Thermostable hemolysin - - - - - - - - - - - - T_hemolysin k59_1248298_1 998674.ATTE01000001_gene3216 9.16e-22 93.6 COG1250@1|root,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,1RY2T@1236|Gammaproteobacteria 1236|Gammaproteobacteria I Dehydrogenase paaH - 1.1.1.157 ko:K00074 ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120 - R01976,R05576,R06941 RC00029,RC00117 ko00000,ko00001,ko01000 - - - 3HCDH,3HCDH_N k59_1248298_2 9986.ENSOCUP00000011893 8.99e-25 103.0 COG0183@1|root,KOG2991@1|root,KOG1390@2759|Eukaryota,KOG2991@2759|Eukaryota,38C4X@33154|Opisthokonta,3BDQV@33208|Metazoa,3CYAF@33213|Bilateria,488WH@7711|Chordata,4964F@7742|Vertebrata,3JAQF@40674|Mammalia,35H86@314146|Euarchontoglires 33208|Metazoa I acetyl-CoA C-acetyltransferase activity ACAT2 GO:0001101,GO:0001889,GO:0003674,GO:0003824,GO:0003985,GO:0003988,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005730,GO:0005737,GO:0005739,GO:0005777,GO:0005829,GO:0006066,GO:0006082,GO:0006091,GO:0006629,GO:0006631,GO:0006635,GO:0006694,GO:0006695,GO:0006720,GO:0007154,GO:0007275,GO:0007399,GO:0007417,GO:0007420,GO:0007584,GO:0008150,GO:0008152,GO:0008202,GO:0008203,GO:0008299,GO:0008610,GO:0009056,GO:0009058,GO:0009062,GO:0009605,GO:0009987,GO:0009991,GO:0010033,GO:0016042,GO:0016054,GO:0016093,GO:0016094,GO:0016125,GO:0016126,GO:0016407,GO:0016408,GO:0016453,GO:0016740,GO:0016746,GO:0016747,GO:0017144,GO:0019348,GO:0019395,GO:0019408,GO:0019752,GO:0030258,GO:0030300,GO:0031667,GO:0031668,GO:0031669,GO:0031670,GO:0031974,GO:0031981,GO:0032368,GO:0032370,GO:0032371,GO:0032373,GO:0032374,GO:0032376,GO:0032501,GO:0032502,GO:0032787,GO:0032879,GO:0033993,GO:0034440,GO:0042221,GO:0042579,GO:0042737,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043436,GO:0044057,GO:0044058,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044249,GO:0044255,GO:0044281,GO:0044282,GO:0044283,GO:0044422,GO:0044424,GO:0044428,GO:0044444,GO:0044446,GO:0044464,GO:0045797,GO:0046165,GO:0046395,GO:0046950,GO:0046952,GO:0048513,GO:0048518,GO:0048731,GO:0048732,GO:0048856,GO:0050789,GO:0050896,GO:0051049,GO:0051050,GO:0051239,GO:0051240,GO:0051716,GO:0055114,GO:0060322,GO:0060456,GO:0061008,GO:0065007,GO:0070013,GO:0070542,GO:0070887,GO:0071229,GO:0071310,GO:0071396,GO:0071398,GO:0071496,GO:0071704,GO:0072329,GO:1901360,GO:1901362,GO:1901568,GO:1901569,GO:1901575,GO:1901576,GO:1901615,GO:1901617,GO:1901700,GO:1901701,GO:1902224,GO:1902652,GO:1902653,GO:1904478,GO:1904480,GO:1904729,GO:1904731,GO:1905952,GO:1905954 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N k59_570271_1 1229909.NSED_05490 3.59e-148 440.0 COG0308@1|root,arCOG02969@2157|Archaea,41SJH@651137|Thaumarchaeota 651137|Thaumarchaeota E Peptidase family M1 domain - - 3.4.11.2 ko:K01256,ko:K13722 ko00480,ko01100,map00480,map01100 - R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 - - - ERAP1_C,Peptidase_M1 k59_1756623_1 1177928.TH2_18531 4.28e-72 232.0 COG1012@1|root,COG1012@2|Bacteria,1MY2V@1224|Proteobacteria,2TTPR@28211|Alphaproteobacteria,2JREB@204441|Rhodospirillales 204441|Rhodospirillales C Aldehyde dehydrogenase family - - 1.2.1.26 ko:K13877 ko00040,ko00053,map00040,map00053 - R00264 RC00080 ko00000,ko00001,ko01000 - - - Aldedh k59_457457_1 113355.CM001775_gene3633 4.39e-26 115.0 COG0155@1|root,COG0155@2|Bacteria,1G21X@1117|Cyanobacteria 1117|Cyanobacteria C Belongs to the nitrite and sulfite reductase 4Fe-4S domain family sir GO:0003674,GO:0003824,GO:0006790,GO:0008150,GO:0008152,GO:0009987,GO:0016002,GO:0016491,GO:0016667,GO:0016673,GO:0019419,GO:0044237,GO:0050311,GO:0055114 1.8.7.1 ko:K00392 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00176 R00859,R03600 RC00065 ko00000,ko00001,ko00002,ko01000 - - - NIR_SIR,NIR_SIR_ferr k59_457457_2 1137269.AZWL01000019_gene4043 2.79e-21 98.2 COG0469@1|root,COG0469@2|Bacteria,2GJY8@201174|Actinobacteria 201174|Actinobacteria G Belongs to the pyruvate kinase family pyk GO:0003674,GO:0003824,GO:0004743,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016052,GO:0016053,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0040007,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0071944,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576 2.7.1.40 ko:K00873 ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230 M00001,M00002,M00049,M00050 R00200,R00430,R01138,R01858,R02320 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - PK,PK_C k59_852990_1 1122137.AQXF01000001_gene3238 4.91e-16 73.2 COG0350@1|root,COG0350@2|Bacteria,1N2YQ@1224|Proteobacteria,2VEUJ@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated ogt - 2.1.1.63 ko:K00567 - - - - ko00000,ko01000,ko03400 - - - DNA_binding_1,Methyltransf_1N k59_852990_2 1122137.AQXF01000001_gene3237 1.74e-154 446.0 COG0486@1|root,COG0486@2|Bacteria,1MUCQ@1224|Proteobacteria,2TQZW@28211|Alphaproteobacteria 28211|Alphaproteobacteria J Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 mnmE - - ko:K03650 - - R08701 RC00053,RC00209,RC00870 ko00000,ko01000,ko03016 - - - MMR_HSR1,MnmE_helical,TrmE_N k59_1022789_1 926569.ANT_00900 3.3e-103 313.0 COG2256@1|root,COG2256@2|Bacteria,2G5JC@200795|Chloroflexi 200795|Chloroflexi L PFAM AAA ATPase central domain protein - - - ko:K07478 - - - - ko00000 - - - AAA,AAA_assoc_2,MgsA_C,RuvB_N k59_1756648_1 1122137.AQXF01000005_gene1257 3.57e-75 231.0 COG1309@1|root,COG1309@2|Bacteria,1RGJ3@1224|Proteobacteria 1224|Proteobacteria K Transcriptional regulator pfiT - - - - - - - - - - - TetR_C_4,TetR_N k59_1248330_1 553385.JEMF01000028_gene3285 2.81e-56 183.0 COG2877@1|root,COG2877@2|Bacteria,1MV91@1224|Proteobacteria,1RMGQ@1236|Gammaproteobacteria,1XHC1@135619|Oceanospirillales 135619|Oceanospirillales M Belongs to the KdsA family kdsA - 2.5.1.55 ko:K01627 ko00540,ko01100,map00540,map01100 M00063 R03254 RC00435 ko00000,ko00001,ko00002,ko01000,ko01005 - - - DAHP_synth_1 k59_1587055_1 626887.J057_14045 4.72e-36 127.0 COG0097@1|root,COG0097@2|Bacteria,1R9YZ@1224|Proteobacteria,1S1Z1@1236|Gammaproteobacteria,466EY@72275|Alteromonadaceae 1236|Gammaproteobacteria J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center rplF GO:0000027,GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070180,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02933 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L6 k59_1587055_2 1122194.AUHU01000017_gene1813 2.36e-70 214.0 COG0096@1|root,COG0096@2|Bacteria,1RDG3@1224|Proteobacteria,1S452@1236|Gammaproteobacteria,46724@72275|Alteromonadaceae 1236|Gammaproteobacteria J One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit rpsH GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009894,GO:0009987,GO:0010467,GO:0010468,GO:0010608,GO:0015935,GO:0016043,GO:0019219,GO:0019222,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0031323,GO:0031329,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043487,GO:0043488,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0061013,GO:0065003,GO:0065007,GO:0065008,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0080090,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903311,GO:1990904 - ko:K02994 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S8 k59_288224_1 243090.RB11088 6.3e-41 154.0 COG0457@1|root,COG0457@2|Bacteria,2IYBX@203682|Planctomycetes 203682|Planctomycetes S ASPIC and UnbV - - - - - - - - - - - - UnbV_ASPIC,VCBS k59_231362_1 768671.ThimaDRAFT_1225 4.16e-06 48.9 COG0688@1|root,COG0688@2|Bacteria,1MVT4@1224|Proteobacteria,1RN1U@1236|Gammaproteobacteria,1WWNF@135613|Chromatiales 135613|Chromatiales I Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Prokaryotic type I sub-subfamily psd - 4.1.1.65 ko:K01613 ko00564,ko01100,ko01110,map00564,map01100,map01110 M00093 R02055 RC00299 ko00000,ko00001,ko00002,ko01000 - - - PS_Dcarbxylase k59_231362_2 1123256.KB907946_gene326 3.67e-13 69.7 COG2847@1|root,COG2847@2|Bacteria,1MZ3M@1224|Proteobacteria,1SCJD@1236|Gammaproteobacteria,1XC27@135614|Xanthomonadales 135614|Xanthomonadales S Copper chaperone PCu(A)C - - - ko:K09796 - - - - ko00000,ko03110 - - - PCuAC k59_400931_1 498211.CJA_0719 2.93e-74 234.0 COG0201@1|root,COG0201@2|Bacteria,1MVU7@1224|Proteobacteria,1RNJV@1236|Gammaproteobacteria,1FGRH@10|Cellvibrio 1236|Gammaproteobacteria U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently secY GO:0002790,GO:0003674,GO:0005048,GO:0005215,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006605,GO:0006612,GO:0006613,GO:0006614,GO:0006616,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0016043,GO:0022857,GO:0022884,GO:0031224,GO:0031226,GO:0031522,GO:0032940,GO:0032978,GO:0032991,GO:0033036,GO:0033218,GO:0033365,GO:0034613,GO:0042277,GO:0042886,GO:0042887,GO:0043952,GO:0044425,GO:0044459,GO:0044464,GO:0045047,GO:0045184,GO:0046903,GO:0046907,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0061024,GO:0065002,GO:0070727,GO:0070972,GO:0071702,GO:0071705,GO:0071806,GO:0071840,GO:0071944,GO:0072594,GO:0072599,GO:0072657,GO:0090150,GO:1904680 - ko:K03076 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5 - - SecY k59_1248334_2 330214.NIDE2297 4.94e-28 120.0 COG1749@1|root,COG1749@2|Bacteria,3J0IF@40117|Nitrospirae 40117|Nitrospirae N Flagellar basal body protein FlaE flgE - - ko:K02390 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - FlaE,Flg_bb_rod,Flg_bbr_C k59_344732_1 31234.CRE26455 4.38e-06 47.8 COG0626@1|root,KOG0053@2759|Eukaryota,38CST@33154|Opisthokonta,3BFVK@33208|Metazoa,3CXAE@33213|Bilateria,40APF@6231|Nematoda,1KUK3@119089|Chromadorea,40XK2@6236|Rhabditida 33208|Metazoa E vitamin B6 binding cth-2 - 4.4.1.1 ko:K01758 ko00260,ko00270,ko00450,ko01100,ko01130,ko01230,map00260,map00270,map00450,map01100,map01130,map01230 M00338 R00782,R01001,R02408,R04770,R04930,R09366 RC00056,RC00069,RC00348,RC00382,RC00710,RC01209,RC01210,RC01245,RC02303 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Cys_Met_Meta_PP k59_344732_2 1249975.JQLP01000005_gene780 1.09e-29 111.0 2CDPK@1|root,32RR8@2|Bacteria,4NSHW@976|Bacteroidetes,1I402@117743|Flavobacteriia,2P7N8@244698|Gillisia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_1643971_1 1415778.JQMM01000001_gene924 1.85e-59 203.0 COG1199@1|root,COG1199@2|Bacteria,1MVCU@1224|Proteobacteria,1RMNX@1236|Gammaproteobacteria,1J4G4@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria KL COG1199 Rad3-related DNA helicases dinG - 3.6.4.12 ko:K03722 - - - - ko00000,ko01000,ko03400 - - - DEAD,DEAD_2,Helicase_C_2,ResIII k59_1361385_1 1229909.NSED_08500 7.25e-31 125.0 arCOG08777@1|root,arCOG08647@2157|Archaea,41SNX@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_965781_1 247634.GPB2148_2801 2.32e-50 174.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria 1236|Gammaproteobacteria T Diguanylate cyclase - - - - - - - - - - - - EAL,GAF,GGDEF,PAS_9 k59_1757619_1 1229909.NSED_07630 1.34e-25 101.0 COG0589@1|root,arCOG02053@2157|Archaea,41TB2@651137|Thaumarchaeota 651137|Thaumarchaeota T COG0589 Universal stress protein UspA and related nucleotide-binding proteins - - - - - - - - - - - - Usp k59_797664_1 765913.ThidrDRAFT_0449 8.17e-47 159.0 COG1305@1|root,COG1305@2|Bacteria,1MWAI@1224|Proteobacteria,1RRMA@1236|Gammaproteobacteria,1WWEH@135613|Chromatiales 135613|Chromatiales E Transglutaminase/protease-like homologues - - - - - - - - - - - - Bact_transglu_N,Transglut_core k59_966638_1 626418.bglu_2g15250 3.88e-53 193.0 COG1201@1|root,COG1201@2|Bacteria,1MUSW@1224|Proteobacteria,2VI8X@28216|Betaproteobacteria,1K1W4@119060|Burkholderiaceae 28216|Betaproteobacteria L DEAD DEAH box helicase domain protein lhr - - ko:K03724 - - - - ko00000,ko01000,ko03400 - - - DEAD,DEAD_assoc,Helicase_C k59_910316_1 1449976.KALB_2190 2.96e-13 69.3 COG0300@1|root,COG0300@2|Bacteria,2GK2K@201174|Actinobacteria,4DZIK@85010|Pseudonocardiales 201174|Actinobacteria S PFAM short chain dehydrogenase - - - - - - - - - - - - adh_short k59_910316_2 1207063.P24_12936 5.65e-07 55.8 COG1595@1|root,COG1595@2|Bacteria,1MZMC@1224|Proteobacteria,2VEWM@28211|Alphaproteobacteria,2JYMT@204441|Rhodospirillales 204441|Rhodospirillales K Sigma-70, region 4 - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 k59_1418503_1 866536.Belba_2495 2.3e-97 301.0 COG5434@1|root,COG5434@2|Bacteria,4NG4T@976|Bacteroidetes,47KBB@768503|Cytophagia 976|Bacteroidetes G Belongs to the glycosyl hydrolase 28 family - - - ko:K19172 - - - - ko00000,ko02048 - - - Glyco_hydro_28,Lipase_GDSL_2,Pectate_lyase_3 k59_627774_1 1122139.KB907884_gene390 9.17e-31 113.0 COG0779@1|root,COG0779@2|Bacteria,1RDP2@1224|Proteobacteria,1S3Y7@1236|Gammaproteobacteria,1XJNA@135619|Oceanospirillales 135619|Oceanospirillales S Required for maturation of 30S ribosomal subunits rimP - - ko:K09748 - - - - ko00000,ko03009 - - - DUF150,DUF150_C k59_627774_2 713586.KB900536_gene3059 6.01e-26 105.0 COG0195@1|root,COG0195@2|Bacteria,1MWT7@1224|Proteobacteria,1RNQS@1236|Gammaproteobacteria,1WVXP@135613|Chromatiales 135613|Chromatiales K Participates in both transcription termination and antitermination nusA - - ko:K02600 - - - - ko00000,ko03009,ko03021 - - - HHH_5,KH_5,NusA_N,S1 k59_1587939_1 330214.NIDE0369 2.85e-54 175.0 COG0712@1|root,COG0712@2|Bacteria,3J1BY@40117|Nitrospirae 40117|Nitrospirae C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation atpH - - ko:K02113 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - OSCP k59_1587939_2 330214.NIDE0370 1.55e-09 57.8 COG0056@1|root,COG0056@2|Bacteria,3J0CZ@40117|Nitrospirae 40117|Nitrospirae C Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit atpA - 3.6.3.14 ko:K02111 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - - ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N k59_1645089_1 981085.XP_010111486.1 0.000317 47.0 KOG0800@1|root,KOG0800@2759|Eukaryota,37VB7@33090|Viridiplantae,3GIVH@35493|Streptophyta,4JQDT@91835|fabids 35493|Streptophyta O RING-H2 finger protein - GO:0003674,GO:0003824,GO:0004842,GO:0006464,GO:0006508,GO:0006511,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0010498,GO:0016567,GO:0016740,GO:0019538,GO:0019787,GO:0019941,GO:0030163,GO:0032446,GO:0036211,GO:0043161,GO:0043170,GO:0043412,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0051603,GO:0061630,GO:0061659,GO:0070647,GO:0071704,GO:0140096,GO:1901564,GO:1901565,GO:1901575 2.3.2.27 ko:K11982,ko:K19041 - - - - ko00000,ko01000,ko04121,ko04131 - - - zf-RING_2 k59_514452_1 331869.BAL199_11366 1.05e-36 134.0 COG0704@1|root,COG0704@2|Bacteria,1MUMI@1224|Proteobacteria,2TQMN@28211|Alphaproteobacteria,4BQFJ@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria P Plays a role in the regulation of phosphate uptake phoU GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009892,GO:0010563,GO:0010966,GO:0019220,GO:0019222,GO:0031323,GO:0031324,GO:0032879,GO:0034762,GO:0034763,GO:0034765,GO:0034766,GO:0042802,GO:0042803,GO:0043269,GO:0043271,GO:0044070,GO:0044424,GO:0044464,GO:0045936,GO:0046983,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051049,GO:0051051,GO:0051174,GO:0065007,GO:1903792,GO:1903795,GO:1903796,GO:1903959,GO:1903960,GO:2000185,GO:2000186 - ko:K02039 - - - - ko00000 - - - PhoU k59_63435_1 484022.Fphi_1566 4.92e-25 99.8 COG0817@1|root,COG0817@2|Bacteria,1MUJI@1224|Proteobacteria,1RQPJ@1236|Gammaproteobacteria,460RU@72273|Thiotrichales 72273|Thiotrichales L Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group ruvC - 3.1.22.4 ko:K01159 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - RuvC k59_63435_2 1036674.A28LD_1675 7.18e-53 174.0 COG0632@1|root,COG0632@2|Bacteria,1MWJR@1224|Proteobacteria,1RMET@1236|Gammaproteobacteria,2QG0Q@267893|Idiomarinaceae 1236|Gammaproteobacteria L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB ruvA GO:0000217,GO:0000400,GO:0000725,GO:0003674,GO:0003676,GO:0003677,GO:0003678,GO:0003824,GO:0004386,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0007154,GO:0008150,GO:0008152,GO:0009314,GO:0009378,GO:0009379,GO:0009432,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0022607,GO:0031668,GO:0032392,GO:0032508,GO:0032991,GO:0033202,GO:0033554,GO:0034641,GO:0042802,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0051259,GO:0051260,GO:0051262,GO:0051276,GO:0051289,GO:0051716,GO:0065003,GO:0071103,GO:0071496,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1902494 3.6.4.12 ko:K03550 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - HHH_5,RuvA_C,RuvA_N k59_910334_1 237368.SCABRO_01551 4.6e-77 259.0 COG3696@1|root,COG3696@2|Bacteria,2IX94@203682|Planctomycetes 203682|Planctomycetes P AcrB/AcrD/AcrF family - - - ko:K07787 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.6.1.4 - - ACR_tran k59_1192838_1 1385515.N791_05880 8.73e-32 122.0 COG3279@1|root,COG3279@2|Bacteria,1R90R@1224|Proteobacteria,1S3H3@1236|Gammaproteobacteria,1X65V@135614|Xanthomonadales 135614|Xanthomonadales KT LytTr DNA-binding domain rpfD - - - - - - - - - - - LytTR k59_1306093_1 883078.HMPREF9695_01350 3.83e-40 144.0 COG0477@1|root,COG2814@2|Bacteria,1MWFH@1224|Proteobacteria,2TR0R@28211|Alphaproteobacteria,3JVQA@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria EGP Major Facilitator Superfamily - - - ko:K08224 - - - - ko00000,ko02000 2.A.1.36 - - MFS_1,Sugar_tr k59_1306093_2 381666.H16_A1812 9.51e-51 167.0 COG1917@1|root,COG1917@2|Bacteria,1PBNJ@1224|Proteobacteria,2VYV4@28216|Betaproteobacteria 28216|Betaproteobacteria S Cupin domain - - - - - - - - - - - - Cupin_2 k59_345870_1 1229909.NSED_05840 7.92e-178 514.0 COG0145@1|root,arCOG01511@2157|Archaea,41SZ7@651137|Thaumarchaeota 651137|Thaumarchaeota E N-methylhydantoinase A acetone carboxylase, beta subunit - - - - - - - - - - - - Hydant_A_N,Hydantoinase_A k59_1532073_2 1117319.PSPO_12457 1.33e-54 176.0 COG2303@1|root,COG2303@2|Bacteria,1RH5U@1224|Proteobacteria,1S60X@1236|Gammaproteobacteria,2Q2WF@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria E Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate - - - - - - - - - - - - - k59_1249227_1 5270.UM01028P0 3.51e-06 50.1 COG0432@1|root,KOG4269@1|root,KOG3267@2759|Eukaryota,KOG4269@2759|Eukaryota,38FSR@33154|Opisthokonta,3NVRI@4751|Fungi,3UXTA@5204|Basidiomycota,3N1TW@452284|Ustilaginomycotina 4751|Fungi T GTPase-activator protein for Rho-like GTPases BEM3 GO:0000131,GO:0003674,GO:0005096,GO:0005488,GO:0005543,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005826,GO:0005856,GO:0005933,GO:0005934,GO:0005937,GO:0005938,GO:0006996,GO:0007010,GO:0007163,GO:0008047,GO:0008150,GO:0008289,GO:0009966,GO:0009968,GO:0009987,GO:0010646,GO:0010648,GO:0015629,GO:0016043,GO:0023051,GO:0023057,GO:0030010,GO:0030234,GO:0030427,GO:0030695,GO:0030863,GO:0030864,GO:0031106,GO:0032153,GO:0032155,GO:0032185,GO:0032266,GO:0035023,GO:0035024,GO:0035091,GO:0035838,GO:0042995,GO:0043085,GO:0043087,GO:0043167,GO:0043168,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043332,GO:0043547,GO:0044093,GO:0044422,GO:0044424,GO:0044430,GO:0044444,GO:0044446,GO:0044448,GO:0044463,GO:0044464,GO:0046578,GO:0046580,GO:0048519,GO:0048523,GO:0048583,GO:0048585,GO:0050789,GO:0050790,GO:0050794,GO:0051056,GO:0051058,GO:0051286,GO:0051336,GO:0051345,GO:0060589,GO:0065007,GO:0065009,GO:0070938,GO:0071840,GO:0071944,GO:0098772,GO:0099568,GO:0120025,GO:0120038,GO:0120105,GO:1901981,GO:1902531,GO:1902532 - ko:K08773,ko:K19840 ko04011,ko04014,ko05200,ko05212,map04011,map04014,map05200,map05212 - - - ko00000,ko00001,ko04131 - - - PH,PX,RhoGAP k59_1249227_2 1229909.NSED_09475 2.4e-99 300.0 COG0531@1|root,arCOG00009@2157|Archaea,41SXX@651137|Thaumarchaeota 651137|Thaumarchaeota E amino acid - - - ko:K03294 - - - - ko00000 2.A.3.2 - - AA_permease_2 k59_63455_1 1042375.AFPL01000038_gene1553 2.1e-93 291.0 COG1960@1|root,COG1960@2|Bacteria,1MU20@1224|Proteobacteria,1RNV1@1236|Gammaproteobacteria,4658Y@72275|Alteromonadaceae 1236|Gammaproteobacteria I Acetyl-CoA dehydrogenase C-terminal like - - - ko:K20035 ko00920,map00920 - R11130 RC03363 ko00000,ko00001,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_C,Acyl-CoA_dh_M,Acyl-CoA_dh_N,AcylCoA_DH_N k59_1136158_1 1121033.AUCF01000010_gene4443 7.93e-86 281.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2TQT0@28211|Alphaproteobacteria,2JPRP@204441|Rhodospirillales 204441|Rhodospirillales V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K18138 ko01501,ko01503,map01501,map01503 M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000 2.A.6.2 - - ACR_tran k59_345879_2 1223545.GS4_11_00730 9.31e-07 58.2 COG2141@1|root,COG2141@2|Bacteria,2GJRF@201174|Actinobacteria,4GC0J@85026|Gordoniaceae 201174|Actinobacteria C Luciferase-like monooxygenase - - - - - - - - - - - - Bac_luciferase k59_1532081_1 1122137.AQXF01000002_gene340 2.89e-171 509.0 COG1391@1|root,COG1391@2|Bacteria,1MU4I@1224|Proteobacteria,2TRY7@28211|Alphaproteobacteria 28211|Alphaproteobacteria H Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell glnE GO:0000820,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006521,GO:0008150,GO:0008882,GO:0010565,GO:0016740,GO:0016772,GO:0016779,GO:0019222,GO:0031323,GO:0033238,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0062012,GO:0065007,GO:0070566,GO:0080090 2.7.7.42,2.7.7.89 ko:K00982 - - - - ko00000,ko01000 - - - GlnD_UR_UTase,GlnE k59_1532081_2 492774.JQMB01000007_gene3858 7.23e-32 115.0 COG1225@1|root,COG1225@2|Bacteria,1RD4R@1224|Proteobacteria,2U6Z9@28211|Alphaproteobacteria,4B855@82115|Rhizobiaceae 28211|Alphaproteobacteria O Peroxiredoxin bcp - 1.11.1.15 ko:K03564 - - - - ko00000,ko01000 - - - AhpC-TSA k59_1475623_1 240015.ACP_0843 5.2e-09 56.6 COG0366@1|root,COG0366@2|Bacteria,3Y2ZW@57723|Acidobacteria,2JICY@204432|Acidobacteriia 204432|Acidobacteriia G Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB glgE - 2.4.99.16 ko:K16147 ko00500,ko01100,map00500,map01100 - R09994 - ko00000,ko00001,ko01000 - GH13 - Alpha-amylase,DUF3416 k59_1475623_2 76114.ebA7001 8.26e-91 293.0 COG0366@1|root,COG3281@1|root,COG0366@2|Bacteria,COG3281@2|Bacteria,1MVKX@1224|Proteobacteria,2VHW5@28216|Betaproteobacteria,2KYAT@206389|Rhodocyclales 206389|Rhodocyclales G Alpha-amylase domain - - 3.2.1.1,5.4.99.16 ko:K05343 ko00500,ko01100,map00500,map01100 - R01557,R02108,R02112,R11262 RC01816 ko00000,ko00001,ko01000 - GH13 - Alpha-amylase,Malt_amylase_C k59_1587969_1 1415778.JQMM01000001_gene154 1.29e-24 102.0 COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,1RNXA@1236|Gammaproteobacteria,1J5BC@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Aminotransferase class I and II IV02_28760 - - - - - - - - - - - Aminotran_1_2 k59_175865_1 1172185.KB911510_gene1315 1.6e-56 198.0 COG0060@1|root,COG0060@2|Bacteria,2GK9M@201174|Actinobacteria,4FWMW@85025|Nocardiaceae 201174|Actinobacteria J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) ileS GO:0003674,GO:0003824,GO:0004812,GO:0004822,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006428,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0030312,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.5 ko:K01870 ko00970,map00970 M00359,M00360 R03656 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,tRNA-synt_1 k59_966678_1 197221.22295969 4.1e-47 174.0 COG0661@1|root,COG0661@2|Bacteria,1G0X9@1117|Cyanobacteria 1117|Cyanobacteria S Unusual protein kinase - - - - - - - - - - - - ABC1 k59_6761_1 83219.PM02_04940 8.39e-46 168.0 COG1018@1|root,COG1600@1|root,COG1018@2|Bacteria,COG1600@2|Bacteria,1MU6E@1224|Proteobacteria,2TRE9@28211|Alphaproteobacteria,3ZUW5@60136|Sulfitobacter 28211|Alphaproteobacteria C 4Fe-4S double cluster binding domain - - - ko:K03863 ko00627,ko01120,map00627,map01120 - R05274 RC00392,RC01533 ko00000,ko00001 - - - Dehalogenase,Fer2,Fer4_16,Fer4_7,NAD_binding_1 k59_1249242_1 1121887.AUDK01000015_gene894 2.6e-150 437.0 COG0702@1|root,COG0702@2|Bacteria,4PKHQ@976|Bacteroidetes,1IJ9C@117743|Flavobacteriia,2P0P3@237|Flavobacterium 976|Bacteroidetes GM SusD family - - - ko:K21572 - - - - ko00000,ko02000 8.A.46.1,8.A.46.3 - - SusD-like_3,SusD_RagB k59_854276_1 870187.Thini_0424 1.33e-93 281.0 COG0492@1|root,COG0492@2|Bacteria,1MV15@1224|Proteobacteria,1RMEX@1236|Gammaproteobacteria,4608I@72273|Thiotrichales 72273|Thiotrichales C Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family trxB - 1.8.1.9 ko:K00384 ko00450,map00450 - R02016,R03596,R09372 RC00013,RC02518,RC02873 ko00000,ko00001,ko01000 - - - Pyr_redox_2 k59_458362_1 1235457.C404_15160 2.62e-205 583.0 COG0481@1|root,COG0481@2|Bacteria,1MVZA@1224|Proteobacteria,2VHM5@28216|Betaproteobacteria,1K0AB@119060|Burkholderiaceae 28216|Betaproteobacteria J Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner lepA - - ko:K03596 ko05134,map05134 - - - ko00000,ko00001 - - - EFG_C,GTP_EFTU,GTP_EFTU_D2,LepA_C k59_1587982_2 990285.RGCCGE502_05739 2.34e-41 144.0 COG2010@1|root,COG2010@2|Bacteria,1MV6D@1224|Proteobacteria,2TT9U@28211|Alphaproteobacteria,4BAVA@82115|Rhizobiaceae 28211|Alphaproteobacteria C Cytochrome c, mono- and diheme variants cycG GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - - - - - - - - - - Cytochrom_C k59_854293_1 1122137.AQXF01000003_gene2012 2.66e-199 563.0 COG1228@1|root,COG1228@2|Bacteria,1MVAF@1224|Proteobacteria,2TTYC@28211|Alphaproteobacteria 28211|Alphaproteobacteria Q COG1228 Imidazolonepropionase and related amidohydrolases - - - - - - - - - - - - Amidohydro_1 k59_571054_1 1415778.JQMM01000001_gene551 8.16e-122 362.0 COG0486@1|root,COG0486@2|Bacteria,1MUCQ@1224|Proteobacteria,1RN5S@1236|Gammaproteobacteria,1J4DQ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 mnmE GO:0000166,GO:0001510,GO:0001882,GO:0001883,GO:0002097,GO:0002098,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005515,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006457,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009268,GO:0009451,GO:0009628,GO:0009636,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019003,GO:0030488,GO:0030955,GO:0031420,GO:0032259,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034470,GO:0034641,GO:0034660,GO:0035639,GO:0036094,GO:0042221,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0050896,GO:0061077,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901363 - ko:K03650 - - R08701 RC00053,RC00209,RC00870 ko00000,ko01000,ko03016 - - - MMR_HSR1,MnmE_helical,TrmE_N k59_1306165_1 1168065.DOK_07639 8.38e-120 362.0 COG4770@1|root,COG4770@2|Bacteria,1P6RE@1224|Proteobacteria,1RM95@1236|Gammaproteobacteria,1J4GW@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria I COG4770 Acetyl propionyl-CoA carboxylase, alpha subunit mccA - 6.4.1.4 ko:K01968 ko00280,ko01100,map00280,map01100 M00036 R04138 RC00367,RC00942 ko00000,ko00001,ko00002,ko01000 - - - Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2 k59_401851_1 266117.Rxyl_2532 3.13e-24 102.0 COG0614@1|root,COG0614@2|Bacteria,2GYJE@201174|Actinobacteria,4CTJ1@84995|Rubrobacteria 84995|Rubrobacteria P Periplasmic binding protein - - - - - - - - - - - - Peripla_BP_2 k59_1249274_1 745718.JADT01000019_gene1536 7.57e-91 274.0 COG0205@1|root,COG0205@2|Bacteria,4NF8F@976|Bacteroidetes,1HWWG@117743|Flavobacteriia 976|Bacteroidetes G Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis pfkA - 2.7.1.11 ko:K00850 ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230 M00001,M00345 R00756,R03236,R03237,R03238,R03239,R04779 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000,ko01009,ko03019 - - - PFK k59_1249274_2 1249975.JQLP01000003_gene93 4.19e-37 133.0 COG0057@1|root,COG0057@2|Bacteria,4NEMF@976|Bacteroidetes,1HYY3@117743|Flavobacteriia,2P5UT@244698|Gillisia 976|Bacteroidetes G Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain gap - 1.2.1.12 ko:K00134 ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01061 RC00149 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - Gp_dh_C,Gp_dh_N k59_1532144_1 1131269.AQVV01000015_gene2014 2.7e-30 119.0 COG1536@1|root,COG1536@2|Bacteria 2|Bacteria N FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation fliG GO:0001539,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006928,GO:0006935,GO:0008150,GO:0009288,GO:0009605,GO:0009987,GO:0040011,GO:0042221,GO:0042330,GO:0042802,GO:0042803,GO:0042995,GO:0043226,GO:0043228,GO:0044403,GO:0044419,GO:0044464,GO:0046982,GO:0046983,GO:0048870,GO:0050896,GO:0051179,GO:0051674,GO:0051701,GO:0051704,GO:0052116,GO:0052126,GO:0052127,GO:0052143,GO:0052192,GO:0052195,GO:0052216,GO:0052243,GO:0071973,GO:0071978,GO:0097588 - ko:K02410 ko02030,ko02040,map02030,map02040 - - - ko00000,ko00001,ko02035 - - - FliG_C,FliG_M,FliG_N k59_1306178_1 13690.CP98_02682 3.98e-33 135.0 COG1629@1|root,COG1629@2|Bacteria,COG4771@2|Bacteria,1MU9K@1224|Proteobacteria,2TTUW@28211|Alphaproteobacteria,2K135@204457|Sphingomonadales 204457|Sphingomonadales P receptor - - - - - - - - - - - - Plug,TonB_dep_Rec k59_175907_1 1479237.JMLY01000001_gene1748 1.83e-25 105.0 COG4067@1|root,COG4067@2|Bacteria,1N0VV@1224|Proteobacteria,1SZUE@1236|Gammaproteobacteria,467V0@72275|Alteromonadaceae 1236|Gammaproteobacteria O protein conserved in archaea - - - - - - - - - - - - Zn_protease k59_1192908_1 398527.Bphyt_4084 2.87e-68 229.0 COG1042@1|root,COG1042@2|Bacteria,1MW98@1224|Proteobacteria,2VI9R@28216|Betaproteobacteria,1K035@119060|Burkholderiaceae 28216|Betaproteobacteria C CoA-binding domain protein - - 6.2.1.13 ko:K01905,ko:K09181,ko:K22224 ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120 - R00229,R00920 RC00004,RC00012,RC00014 ko00000,ko00001,ko01000,ko01004 - - - ATP-grasp_5,Acetyltransf_1,Acetyltransf_3,Acetyltransf_4,CoA_binding_2,Succ_CoA_lig k59_232143_1 397945.Aave_3914 1.08e-09 60.1 COG1192@1|root,COG1192@2|Bacteria,1QBJX@1224|Proteobacteria,2VJNI@28216|Betaproteobacteria,4ABG3@80864|Comamonadaceae 28216|Betaproteobacteria D Cobyrinic acid ac-diamide synthase - - - ko:K03496 - - - - ko00000,ko03036,ko04812 - - - AAA_31,CbiA k59_232143_2 391600.ABRU01000006_gene344 3.71e-23 96.7 COG1171@1|root,COG1171@2|Bacteria,1MVWJ@1224|Proteobacteria,2TQN9@28211|Alphaproteobacteria,2KF7B@204458|Caulobacterales 204458|Caulobacterales E PFAM Pyridoxal-5'-phosphate-dependent protein beta subunit - - 4.3.1.19 ko:K01754 ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230 M00570 R00220,R00996 RC00418,RC02600 ko00000,ko00001,ko00002,ko01000 - - - PALP k59_1249296_1 926569.ANT_22970 3.26e-62 210.0 COG0531@1|root,COG0531@2|Bacteria,2G5ZF@200795|Chloroflexi 200795|Chloroflexi E Amino acid permease - - - - - - - - - - - - AA_permease_2 k59_6818_1 1168034.FH5T_03525 2.32e-46 164.0 COG3307@1|root,COG3307@2|Bacteria,4NMYT@976|Bacteroidetes 976|Bacteroidetes M O-Antigen ligase - - - - - - - - - - - - Wzy_C k59_1701108_1 1121422.AUMW01000001_gene2315 4.84e-46 167.0 COG0475@1|root,COG0475@2|Bacteria,1TS32@1239|Firmicutes,25C8C@186801|Clostridia,260PV@186807|Peptococcaceae 186801|Clostridia P PFAM sodium hydrogen exchanger - - - ko:K03455 - - - - ko00000 2.A.37 - - Na_H_Exchanger k59_1701108_2 1324957.K933_03350 1.86e-18 85.5 COG0490@1|root,arCOG01970@2157|Archaea,2XWSV@28890|Euryarchaeota,23VCF@183963|Halobacteria 183963|Halobacteria P regulatory, ligand-binding protein related to C-terminal domains of K channels - - - ko:K07228 - - - - ko00000 - - - TrkA_C k59_1588027_1 450851.PHZ_c3512 1.62e-23 100.0 2BMBJ@1|root,32FVP@2|Bacteria,1MYA5@1224|Proteobacteria,2UQZK@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_1588027_2 420324.KI912045_gene4612 3.98e-16 73.2 2EHHF@1|root,33B9C@2|Bacteria,1N3NN@1224|Proteobacteria,2UC59@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_1475713_1 1122137.AQXF01000004_gene1438 2.81e-228 636.0 COG0719@1|root,COG0719@2|Bacteria,1MVKY@1224|Proteobacteria,2TRU6@28211|Alphaproteobacteria 28211|Alphaproteobacteria O ABC-type transport system involved in Fe-S cluster assembly, permease component sufB GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0009536,GO:0009842,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464 - ko:K09014 - - - - ko00000 - - - UPF0051 k59_1136224_1 1397527.Q670_07595 1.97e-27 108.0 COG0609@1|root,COG0609@2|Bacteria,1MV9W@1224|Proteobacteria,1RMDF@1236|Gammaproteobacteria,1XIUS@135619|Oceanospirillales 135619|Oceanospirillales P Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily hmuU - - ko:K02015 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko02000 3.A.1.14 - - FecCD k59_1136224_2 1206726.BAFV01000037_gene2461 4.39e-22 95.9 COG4559@1|root,COG4559@2|Bacteria,2GMUI@201174|Actinobacteria,4FVC2@85025|Nocardiaceae 201174|Actinobacteria P Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system hmuV - 1.14.15.20,3.6.3.34 ko:K02013,ko:K21480 ko00860,ko01100,ko01110,ko02010,map00860,map01100,map01110,map02010 M00240 R11579 RC01270 ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.14 - - ABC_tran k59_797815_1 305700.B447_01456 6.51e-59 200.0 COG0323@1|root,COG0323@2|Bacteria,1MV61@1224|Proteobacteria,2VIBW@28216|Betaproteobacteria,2KVF9@206389|Rhodocyclales 206389|Rhodocyclales L This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex mutL - - ko:K03572 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - DNA_mis_repair,HATPase_c_3,MutL_C k59_1707368_1 1229909.NSED_09905 4.98e-88 279.0 COG1293@1|root,arCOG01695@2157|Archaea,41SB0@651137|Thaumarchaeota 651137|Thaumarchaeota K Fibronectin-binding protein A N-terminus (FbpA) - - - - - - - - - - - - DUF814,FbpA k59_1538605_1 1122137.AQXF01000001_gene2818 7.37e-118 350.0 COG0811@1|root,COG0811@2|Bacteria,1MX5J@1224|Proteobacteria,2U43Q@28211|Alphaproteobacteria 28211|Alphaproteobacteria U MotA TolQ ExbB proton channel - - - ko:K03561 - - - - ko00000,ko02000 1.A.30.2.1 - - MotA_ExbB k59_1538605_2 1122137.AQXF01000001_gene2819 7.24e-98 287.0 COG0811@1|root,COG0811@2|Bacteria,1MX60@1224|Proteobacteria,2UAB1@28211|Alphaproteobacteria 28211|Alphaproteobacteria U TonB system transport protein ExbB - - - ko:K03561 - - - - ko00000,ko02000 1.A.30.2.1 - - MotA_ExbB k59_1538605_3 1122137.AQXF01000001_gene2820 1.51e-66 205.0 COG0848@1|root,COG0848@2|Bacteria,1RHQ3@1224|Proteobacteria 1224|Proteobacteria U biopolymer transport protein - - - ko:K03559 - - - - ko00000,ko02000 1.A.30.2.1 - - ExbD k59_296886_1 1382306.JNIM01000001_gene744 0.000642 48.5 COG0668@1|root,COG0668@2|Bacteria 2|Bacteria M transmembrane transport cmpX - - - - - - - - - - - MS_channel,TM_helix k59_1313766_1 702113.PP1Y_AT29621 2.37e-07 50.8 COG0703@1|root,COG0703@2|Bacteria,1MUFJ@1224|Proteobacteria,2U76C@28211|Alphaproteobacteria,2K4PP@204457|Sphingomonadales 204457|Sphingomonadales F Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate aroK - 2.7.1.71 ko:K00891 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02412 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - SKI k59_1313766_2 1096930.L284_23250 2.69e-111 328.0 COG0337@1|root,COG0337@2|Bacteria,1MUBK@1224|Proteobacteria,2TRDA@28211|Alphaproteobacteria,2K0HR@204457|Sphingomonadales 204457|Sphingomonadales E Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) aroB - 4.2.3.4 ko:K01735 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R03083 RC00847 ko00000,ko00001,ko00002,ko01000 - - - DHQ_synthase k59_1708392_1 1042377.AFPJ01000020_gene2064 2.49e-91 282.0 COG3119@1|root,COG3119@2|Bacteria,1MUJH@1224|Proteobacteria,1RN2V@1236|Gammaproteobacteria 1236|Gammaproteobacteria P COG3119 Arylsulfatase A and related enzymes - - 3.1.6.1 ko:K01130 ko00140,ko00600,map00140,map00600 - R03980,R04856 RC00128,RC00231 ko00000,ko00001,ko01000 - - - Sulfatase,Sulfatase_C k59_1539544_1 1207063.P24_09931 1.31e-62 201.0 COG0714@1|root,COG0714@2|Bacteria,1MV5I@1224|Proteobacteria,2TREB@28211|Alphaproteobacteria,2JQDG@204441|Rhodospirillales 204441|Rhodospirillales S AAA domain (dynein-related subfamily) - - - - - - - - - - - - AAA,AAA_5 k59_1539544_2 1122929.KB908238_gene1373 2.56e-07 52.0 COG3552@1|root,COG3552@2|Bacteria,1MUHH@1224|Proteobacteria,2TSXR@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Protein containing von Willebrand factor type A (VWA) domain MA20_09405 - - ko:K07161 - - - - ko00000 - - - VWA_CoxE k59_239461_1 1122137.AQXF01000002_gene25 8.27e-117 353.0 COG3206@1|root,COG3206@2|Bacteria,1MVBX@1224|Proteobacteria,2U1E2@28211|Alphaproteobacteria 28211|Alphaproteobacteria M Chain-length determining protein - - - - - - - - - - - - GNVR,Wzz k59_71087_1 377629.TERTU_1881 1.96e-29 115.0 COG3115@1|root,COG3115@2|Bacteria,1MVHR@1224|Proteobacteria,1RMDB@1236|Gammaproteobacteria,2PNEH@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria D ZipA, C-terminal domain (FtsZ-binding) zipA GO:0000278,GO:0000281,GO:0000910,GO:0000917,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0007049,GO:0008150,GO:0009987,GO:0016020,GO:0016021,GO:0016043,GO:0022402,GO:0022607,GO:0031224,GO:0031226,GO:0032153,GO:0032506,GO:0044085,GO:0044425,GO:0044459,GO:0044464,GO:0051301,GO:0061640,GO:0071840,GO:0071944,GO:0090529,GO:1902410,GO:1903047 - ko:K03528 - - - - ko00000,ko03036 - - - ZipA_C k59_409214_1 1043205.AFYF01000011_gene1405 1.54e-63 218.0 COG2905@1|root,COG2905@2|Bacteria,2I91C@201174|Actinobacteria,4FEXU@85021|Intrasporangiaceae 201174|Actinobacteria T Putative nucleotidyltransferase DUF294 - - - ko:K07182 - - - - ko00000 - - - CBS,DUF294,DUF294_C,cNMP_binding k59_296899_1 999611.KI421504_gene424 1.49e-43 158.0 COG0793@1|root,COG0793@2|Bacteria,1MU39@1224|Proteobacteria,2TRW2@28211|Alphaproteobacteria,280GI@191028|Leisingera 28211|Alphaproteobacteria M Peptidase family S41 ctpA - 3.4.21.102 ko:K03797 - - - - ko00000,ko01000,ko01002 - - - PDZ_2,Peptidase_S41 k59_1143428_1 502025.Hoch_5252 2.44e-70 239.0 COG0745@1|root,COG1340@1|root,COG1352@1|root,COG2201@1|root,COG2203@1|root,COG5002@1|root,COG0745@2|Bacteria,COG1340@2|Bacteria,COG1352@2|Bacteria,COG2201@2|Bacteria,COG2203@2|Bacteria,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,42NK9@68525|delta/epsilon subdivisions,2WMCQ@28221|Deltaproteobacteria 28221|Deltaproteobacteria T Response regulator receiver - - 2.1.1.80,3.1.1.61 ko:K13924 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko02022,ko02035 - - - CheB_methylest,CheR,CheR_N,GAF_2,HATPase_c,HisKA,PAS_10,PAS_3,PAS_4,PAS_9,Response_reg k59_747877_1 1502852.FG94_04192 9.88e-61 202.0 COG1538@1|root,COG1538@2|Bacteria,1MWB0@1224|Proteobacteria,2VIIW@28216|Betaproteobacteria,473BE@75682|Oxalobacteraceae 28216|Betaproteobacteria MU Outer membrane efflux protein copB - - - - - - - - - - - OEP k59_521710_1 13690.CP98_02160 5.39e-77 237.0 2CFS3@1|root,32S2D@2|Bacteria,1N23S@1224|Proteobacteria,2U9XJ@28211|Alphaproteobacteria,2K236@204457|Sphingomonadales 204457|Sphingomonadales - - - - - - - - - - - - - - - k59_1370286_1 436308.Nmar_0088 3.15e-118 364.0 COG1201@1|root,arCOG00557@2157|Archaea,41S8P@651137|Thaumarchaeota 651137|Thaumarchaeota L DEAD/H associated - - - ko:K03724 - - - - ko00000,ko01000,ko03400 - - - DEAD,DEAD_assoc,Helicase_C k59_1143429_1 937777.Deipe_1181 1.67e-61 200.0 COG0022@1|root,COG0022@2|Bacteria,1WINY@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus C Pyruvate 2-oxoglutarate dehydrogenase complex dehydrogenase (E1) component eukaryotic type beta subunit - - 1.2.4.4 ko:K00167 ko00280,ko00640,ko01100,ko01110,ko01130,map00280,map00640,map01100,map01110,map01130 M00036 R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997 RC00027,RC00627,RC02743,RC02883,RC02949,RC02953 br01601,ko00000,ko00001,ko00002,ko01000 - - - Transket_pyr,Transketolase_C k59_127204_1 436308.Nmar_0381 7.66e-117 343.0 COG0244@1|root,arCOG04288@2157|Archaea,41S9R@651137|Thaumarchaeota 651137|Thaumarchaeota J Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors rpl10 - - ko:K02864 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L10 k59_409231_1 933801.Ahos_1684 3.02e-21 90.5 COG0509@1|root,arCOG01303@2157|Archaea 2157|Archaea E The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein gcvH3 - - - - - - - - - - - GCV_H k59_409231_2 1292034.OR37_00458 1.18e-09 57.0 COG0640@1|root,COG0640@2|Bacteria,1N72Q@1224|Proteobacteria,2UFSY@28211|Alphaproteobacteria,2KIXV@204458|Caulobacterales 204458|Caulobacterales K helix_turn_helix, Arsenical Resistance Operon Repressor - - - - - - - - - - - - HTH_5 k59_917703_1 1229909.NSED_00835 9.78e-209 586.0 COG2368@1|root,arCOG02143@2157|Archaea,41SA0@651137|Thaumarchaeota 651137|Thaumarchaeota Q Vinylacetyl-CoA Delta-isomerase - - 4.2.1.120,5.3.3.3 ko:K14534 ko00650,ko00720,ko01100,ko01120,ko01200,map00650,map00720,map01100,map01120,map01200 M00374,M00375 R03031,R10782 RC01857,RC03277 ko00000,ko00001,ko00002,ko01000 - - - HpaB,HpaB_N k59_1708407_1 1096930.L284_04280 1.67e-103 310.0 COG0451@1|root,COG0451@2|Bacteria,1MV73@1224|Proteobacteria,2TU81@28211|Alphaproteobacteria,2K2D3@204457|Sphingomonadales 204457|Sphingomonadales M Polysaccharide biosynthesis protein ddhB - 4.2.1.45 ko:K01709 ko00520,map00520 - R02426 RC00402 ko00000,ko00001,ko01000 - - - GDP_Man_Dehyd k59_1708407_2 1096930.L284_04275 1.03e-34 125.0 COG1208@1|root,COG1208@2|Bacteria,1MUYJ@1224|Proteobacteria,2TS7U@28211|Alphaproteobacteria,2K0R7@204457|Sphingomonadales 204457|Sphingomonadales JM Nucleotidyl transferase - - 2.7.7.33 ko:K00978 ko00500,ko00520,ko01100,map00500,map00520,map01100 - R00956 RC00002 ko00000,ko00001,ko01000 - - - NTP_transferase k59_1143440_1 118163.Ple7327_2520 7.69e-10 61.2 COG0363@1|root,COG0363@2|Bacteria,1G20H@1117|Cyanobacteria,3VI27@52604|Pleurocapsales 1117|Cyanobacteria G PFAM Glucosamine-6-phosphate isomerases 6-phosphogluconolactonase pgl GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009051,GO:0009117,GO:0009987,GO:0016787,GO:0016788,GO:0017057,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046496,GO:0051156,GO:0051186,GO:0052689,GO:0055086,GO:0071704,GO:0072524,GO:1901135,GO:1901360,GO:1901564 3.1.1.31 ko:K01057 ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200 M00004,M00006,M00008 R02035 RC00537 ko00000,ko00001,ko00002,ko01000 - - - Glucosamine_iso k59_1143440_2 311402.Avi_7570 1.74e-23 100.0 COG0364@1|root,COG0364@2|Bacteria,1MUN0@1224|Proteobacteria,2TQXA@28211|Alphaproteobacteria,4B71R@82115|Rhizobiaceae 28211|Alphaproteobacteria G Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone - - 1.1.1.363,1.1.1.49 ko:K00036 ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230 M00004,M00006,M00008 R00835,R02736,R10907 RC00001,RC00066 ko00000,ko00001,ko00002,ko01000,ko04147 - - - G6PD_C,G6PD_N k59_1031496_1 1248760.ANFZ01000002_gene3047 4.96e-43 143.0 COG0347@1|root,COG0347@2|Bacteria,1RGWK@1224|Proteobacteria,2U952@28211|Alphaproteobacteria,2K4EF@204457|Sphingomonadales 204457|Sphingomonadales K Belongs to the P(II) protein family - - - ko:K04752 - - - - ko00000 - - - P-II k59_1031496_2 1537715.JQFJ01000002_gene1615 1.09e-16 79.7 COG0004@1|root,COG0004@2|Bacteria,1NR9F@1224|Proteobacteria,2TT2J@28211|Alphaproteobacteria,2K0PX@204457|Sphingomonadales 204457|Sphingomonadales P Ammonium Transporter amt - - ko:K03320 - - - - ko00000,ko02000 1.A.11 - - Ammonium_transp k59_1313804_1 1187851.A33M_3329 4.23e-28 115.0 2C5GI@1|root,2Z8C1@2|Bacteria,1R8XM@1224|Proteobacteria,2TUME@28211|Alphaproteobacteria 28211|Alphaproteobacteria S P22 coat protein - gene protein 5 - - - - - - - - - - - - P22_CoatProtein k59_1087056_1 1280946.HY29_14690 3.57e-60 198.0 COG2175@1|root,COG2175@2|Bacteria,1MV5K@1224|Proteobacteria,2U38D@28211|Alphaproteobacteria 28211|Alphaproteobacteria Q taurine catabolism dioxygenase - - 1.14.11.17 ko:K03119 ko00430,ko00920,map00430,map00920 - R05320 RC01331 ko00000,ko00001,ko01000 - - - TauD k59_578737_2 1110502.TMO_1068 0.000396 42.7 COG0642@1|root,COG0642@2|Bacteria,1NXDJ@1224|Proteobacteria,2TW2Q@28211|Alphaproteobacteria 28211|Alphaproteobacteria T Histidine kinase - - - - - - - - - - - - HATPase_c,HisKA k59_127223_1 1349767.GJA_4519 5.03e-28 107.0 COG1999@1|root,COG1999@2|Bacteria,1RHJ8@1224|Proteobacteria,2VR3M@28216|Betaproteobacteria,473BA@75682|Oxalobacteraceae 28216|Betaproteobacteria S Involved in biogenesis of respiratory and photosynthetic systems senC - - ko:K07152 - - - - ko00000,ko03029 - - - SCO1-SenC k59_127223_2 123899.JPQP01000003_gene1415 6.05e-16 77.0 COG0109@1|root,COG0109@2|Bacteria,1MW3S@1224|Proteobacteria,2VHZU@28216|Betaproteobacteria,3T1WG@506|Alcaligenaceae 28216|Betaproteobacteria O Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group ctaB - 2.5.1.141 ko:K02257 ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714 M00154 R07411 RC01786 ko00000,ko00001,ko00002,ko01000,ko01006,ko03029 - - - UbiA k59_1313805_1 436308.Nmar_0502 1.67e-13 65.1 arCOG08761@1|root,arCOG08761@2157|Archaea,41T5T@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1313805_2 436308.Nmar_0501 1.88e-76 233.0 COG0671@1|root,arCOG03056@2157|Archaea,41SQ8@651137|Thaumarchaeota 651137|Thaumarchaeota I Acid phosphatase homologues - - 3.6.1.27 ko:K19302 ko00550,map00550 - R05627 RC00002 ko00000,ko00001,ko01000,ko01011 - - - PAP2 k59_409247_1 1122207.MUS1_12585 5.35e-85 266.0 COG0069@1|root,COG0069@2|Bacteria,1MU7B@1224|Proteobacteria,1RP1C@1236|Gammaproteobacteria,1XH9N@135619|Oceanospirillales 135619|Oceanospirillales E Belongs to the glutamate synthase family - - - - - - - - - - - - Glu_synthase k59_1200372_1 1122951.ATUE01000005_gene1790 4.65e-67 211.0 COG3039@1|root,COG3039@2|Bacteria,1MXTN@1224|Proteobacteria,1RM94@1236|Gammaproteobacteria,3NISW@468|Moraxellaceae 1236|Gammaproteobacteria L Transposase DDE domain - - - - - - - - - - - - DDE_Tnp_1,DDE_Tnp_1_5 k59_183574_1 1463861.JNXE01000017_gene7641 4.16e-41 155.0 COG1020@1|root,COG1020@2|Bacteria,2GISR@201174|Actinobacteria 201174|Actinobacteria Q Non-ribosomal peptide synthetase modules and related proteins - - 6.3.2.14 ko:K02364 ko01053,ko01110,ko01130,map01053,map01110,map01130 - R07644 RC00162,RC03046 ko00000,ko00001,ko01000,ko01008 - - - AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase k59_1370310_1 686578.AFFX01000013_gene2211 1.52e-85 270.0 COG1752@1|root,COG1752@2|Bacteria,1PDQ2@1224|Proteobacteria,1RMWI@1236|Gammaproteobacteria 1236|Gammaproteobacteria S esterase of the alpha-beta hydrolase superfamily - - - ko:K07001 - - - - ko00000 - - - Patatin k59_1256686_1 357808.RoseRS_1961 8.89e-79 248.0 COG0065@1|root,COG0065@2|Bacteria,2G68G@200795|Chloroflexi,3753P@32061|Chloroflexia 32061|Chloroflexia H Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate - - 4.2.1.33,4.2.1.35 ko:K01703 ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230 M00432,M00535 R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170 RC00497,RC00976,RC00977,RC01041,RC01046,RC03072 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase k59_353426_1 1121935.AQXX01000081_gene1102 6.49e-31 125.0 COG2937@1|root,COG2937@2|Bacteria,1MWZ6@1224|Proteobacteria,1RM7K@1236|Gammaproteobacteria,1XHAM@135619|Oceanospirillales 135619|Oceanospirillales I Belongs to the GPAT DAPAT family plsB - 2.3.1.15 ko:K00631 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R00851,R09380 RC00004,RC00039,RC00041 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Acyltransferase k59_465658_1 1229909.NSED_08160 6.96e-78 238.0 arCOG08637@1|root,arCOG08637@2157|Archaea,41SV0@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1087077_1 383381.EH30_09920 3.86e-101 311.0 COG4147@1|root,COG4147@2|Bacteria,1MVJ8@1224|Proteobacteria,2TTA4@28211|Alphaproteobacteria,2K3ET@204457|Sphingomonadales 204457|Sphingomonadales S Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family actP - - ko:K14393 - - - - ko00000,ko02000 2.A.21.7 - - SSF k59_183592_1 42565.FP66_07605 2.23e-69 224.0 COG4536@1|root,COG4536@2|Bacteria,1NZ99@1224|Proteobacteria,1RNCE@1236|Gammaproteobacteria,1XH4G@135619|Oceanospirillales 135619|Oceanospirillales P Mg2 and Co2 transporter CorB - - - - - - - - - - - - CBS,CorC_HlyC,DUF21 k59_239523_1 1217720.ALOX01000027_gene3643 5.88e-05 52.4 COG0642@1|root,COG2205@2|Bacteria,1MUAK@1224|Proteobacteria,2TQRE@28211|Alphaproteobacteria,2JYXS@204441|Rhodospirillales 204441|Rhodospirillales T HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - - - - - - - - - - - HAMP,HATPase_c k59_1652566_1 4950.XP_003682265.1 1.83e-05 47.8 COG2935@1|root,KOG1193@2759|Eukaryota,38C7Y@33154|Opisthokonta,3NX69@4751|Fungi,3QKKF@4890|Ascomycota,3RT40@4891|Saccharomycetes,3S0R4@4893|Saccharomycetaceae 4751|Fungi O to Saccharomyces cerevisiae ATE1 (YGL017W) ATE1 GO:0003674,GO:0003824,GO:0004057,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006508,GO:0006511,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016598,GO:0016740,GO:0016746,GO:0016755,GO:0019538,GO:0019941,GO:0030163,GO:0036211,GO:0043170,GO:0043412,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044464,GO:0051603,GO:0071704,GO:0140096,GO:1901564,GO:1901565,GO:1901575 2.3.2.8 ko:K00685 - - R03862 RC00055,RC00064 ko00000,ko01000,ko03016 - - - ATE_C,ATE_N k59_1425949_1 1545915.JROG01000003_gene608 4.23e-42 139.0 COG3335@1|root,COG3335@2|Bacteria,1RIN2@1224|Proteobacteria,2VEVT@28211|Alphaproteobacteria,2KDU3@204457|Sphingomonadales 204457|Sphingomonadales L DDE superfamily endonuclease - - - - - - - - - - - - DDE_3 k59_1425949_2 1502851.FG93_02462 2.86e-43 146.0 COG3415@1|root,COG3415@2|Bacteria,1RDMQ@1224|Proteobacteria,2U7PU@28211|Alphaproteobacteria,3K38Q@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria L Winged helix-turn helix - - - - - - - - - - - - HTH_29,HTH_32,HTH_33 k59_1425950_1 765914.ThisiDRAFT_0242 7.16e-83 256.0 COG0182@1|root,COG0182@2|Bacteria,1MUPM@1224|Proteobacteria,1RMGC@1236|Gammaproteobacteria,1WWQU@135613|Chromatiales 135613|Chromatiales E Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P) mtnA - 5.3.1.23 ko:K08963 ko00270,ko01100,map00270,map01100 M00034 R04420 RC01151 ko00000,ko00001,ko00002,ko01000 - - - IF-2B k59_635272_1 1048834.TC41_3123 4.73e-06 51.2 COG0745@1|root,COG0745@2|Bacteria,1W37V@1239|Firmicutes,4ISYX@91061|Bacilli,279XF@186823|Alicyclobacillaceae 91061|Bacilli T cheY-homologous receiver domain spo0F - - ko:K02490 ko02020,ko02024,map02020,map02024 M00485 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg k59_14287_1 419947.MRA_1259 0.000735 48.5 COG1112@1|root,COG2251@1|root,COG1112@2|Bacteria,COG2251@2|Bacteria,2GMX8@201174|Actinobacteria,235G4@1762|Mycobacteriaceae 201174|Actinobacteria L nuclease - - - - - - - - - - - - AAA_12,AAA_30,RNase_H_2 k59_1595603_1 316056.RPC_4213 1.01e-68 229.0 COG0277@1|root,COG0277@2|Bacteria,1MV1Q@1224|Proteobacteria,2TSVE@28211|Alphaproteobacteria,3JR74@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria C FAD binding domain - - - - - - - - - - - - ALO,FAD_binding_4 k59_14293_1 316407.85676210 1.93e-152 439.0 COG0043@1|root,COG0043@2|Bacteria,1MU62@1224|Proteobacteria,1RNH8@1236|Gammaproteobacteria,3XMYJ@561|Escherichia 1236|Gammaproteobacteria H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol, an intermediate step in ubiquinone biosynthesis ubiD GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0008694,GO:0009058,GO:0009108,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0042180,GO:0042181,GO:0042802,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901661,GO:1901663 4.1.1.98 ko:K03182 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00117 R04985,R04986 RC00391 ko00000,ko00001,ko00002,ko01000 - - iECO111_1330.ECO111_4669 UbiD k59_1708463_1 573065.Astex_0384 1.69e-137 412.0 COG0243@1|root,COG0243@2|Bacteria,1MU6B@1224|Proteobacteria,2TTUX@28211|Alphaproteobacteria,2KHQ2@204458|Caulobacterales 204458|Caulobacterales C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - - - - - - - - - - - Molybdopterin,Molydop_binding k59_183610_1 314345.SPV1_05467 8.47e-128 378.0 COG1233@1|root,COG1233@2|Bacteria,1MV2R@1224|Proteobacteria 1224|Proteobacteria Q COG1233 Phytoene dehydrogenase and related proteins - - 1.3.99.23,5.2.1.13 ko:K09516,ko:K09835 ko00830,ko00906,ko01100,ko01110,map00830,map00906,map01100,map01110 M00097 R07163,R07512 RC01835,RC01960 ko00000,ko00001,ko00002,ko01000 - - - Amino_oxidase,NAD_binding_8 k59_409291_1 630626.EBL_c13660 1.32e-107 320.0 COG3435@1|root,COG3435@2|Bacteria,1MVJP@1224|Proteobacteria,1RYBU@1236|Gammaproteobacteria 1236|Gammaproteobacteria Q Gentisate 1,2-dioxygenase gtdA - 1.13.11.4 ko:K00450 ko00350,ko01100,ko01120,map00350,map01100,map01120 - R02656 RC00764 ko00000,ko00001,ko01000 - - - Cupin_2 k59_296954_1 637905.SVI_1657 3.82e-10 66.2 COG2091@1|root,COG2091@2|Bacteria,1MY8E@1224|Proteobacteria,1RQAI@1236|Gammaproteobacteria,2QAPJ@267890|Shewanellaceae 1236|Gammaproteobacteria H Carbohydrate family 9 binding domain-like - - - - - - - - - - - - CBM9_1 k59_691791_1 436308.Nmar_0970 3.1e-52 165.0 arCOG08644@1|root,arCOG08644@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_691791_2 436308.Nmar_0967 3.75e-60 200.0 COG0215@1|root,arCOG00486@2157|Archaea,41SEW@651137|Thaumarchaeota 651137|Thaumarchaeota J PFAM tRNA synthetases class I (C) catalytic domain cysS - 6.1.1.16 ko:K01883 ko00970,map00970 M00359,M00360 R03650 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DALR_2,tRNA-synt_1e,tRNA-synt_1g k59_1370346_1 511145.b4025 3.5e-151 437.0 COG0166@1|root,COG0166@2|Bacteria,1MUFP@1224|Proteobacteria,1RNIT@1236|Gammaproteobacteria,3XNB8@561|Escherichia 1236|Gammaproteobacteria F Belongs to the GPI family pgi GO:0003674,GO:0003824,GO:0004347,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0033554,GO:0034404,GO:0034599,GO:0034641,GO:0034654,GO:0034655,GO:0042221,GO:0042802,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046939,GO:0050896,GO:0051186,GO:0051188,GO:0051716,GO:0055086,GO:0070887,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576 5.3.1.9 ko:K01810 ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200 M00001,M00004,M00114 R02739,R02740,R03321 RC00376,RC00563 ko00000,ko00001,ko00002,ko01000,ko04147 - - iEcSMS35_1347.EcSMS35_4486 PGI k59_1313866_1 436308.Nmar_0781 7.14e-110 329.0 COG0034@1|root,arCOG00093@2157|Archaea,41S7N@651137|Thaumarchaeota 651137|Thaumarchaeota F Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine purF - 2.4.2.14 ko:K00764 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048 R01072 RC00010,RC02724,RC02752 ko00000,ko00001,ko00002,ko01000,ko01002 - - - GATase_6,Pribosyltran k59_1765139_1 258533.BN977_06297 5.95e-53 183.0 COG2072@1|root,COG2072@2|Bacteria,2GKYU@201174|Actinobacteria,234M3@1762|Mycobacteriaceae 201174|Actinobacteria P flavoprotein involved in K transport - - 1.14.13.22 ko:K03379 ko00930,ko01120,ko01220,map00930,map01120,map01220 - R02231,R06622 RC00662,RC01550 ko00000,ko00001,ko01000 - - - FMO-like,NAD_binding_8,Pyr_redox_2,Pyr_redox_3 k59_578804_1 765698.Mesci_2774 5.75e-38 147.0 COG0323@1|root,COG4191@1|root,COG0323@2|Bacteria,COG4191@2|Bacteria,1ND4X@1224|Proteobacteria,2U54V@28211|Alphaproteobacteria,43P11@69277|Phyllobacteriaceae 28211|Alphaproteobacteria T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - HATPase_c,HATPase_c_3 k59_1708475_1 880072.Desac_1564 2.28e-50 171.0 COG1253@1|root,COG1253@2|Bacteria,1MV3P@1224|Proteobacteria,42QX1@68525|delta/epsilon subdivisions,2WMNH@28221|Deltaproteobacteria,2MRNR@213462|Syntrophobacterales 28221|Deltaproteobacteria S CBS domain containing protein corC - - ko:K06189 - - - - ko00000,ko02000 9.A.40.1.2 - - CBS,CorC_HlyC,DUF21 k59_521808_1 530564.Psta_4529 8.34e-06 53.1 COG0745@1|root,COG1716@1|root,COG5002@1|root,COG0745@2|Bacteria,COG1716@2|Bacteria,COG5002@2|Bacteria,2J4Z7@203682|Planctomycetes 203682|Planctomycetes T SMART ATP-binding region ATPase domain protein - - - - - - - - - - - - HATPase_c,HisKA,Hpt,PAS_4,PAS_9,Response_reg k59_409309_1 247634.GPB2148_15 4.85e-100 310.0 COG2303@1|root,COG2303@2|Bacteria,1MU3F@1224|Proteobacteria,1RPBQ@1236|Gammaproteobacteria,1J5ZV@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E COG2303 Choline dehydrogenase and related flavoproteins neoG - - - - - - - - - - - FAD_binding_2,GMC_oxred_C,GMC_oxred_N,NAD_binding_8 k59_805313_1 945543.VIBR0546_03080 2.99e-35 139.0 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1XSRH@135623|Vibrionales 135623|Vibrionales T signal transduction protein containing a membrane domain, an EAL and a GGDEF domain - - - - - - - - - - - - EAL,GGDEF,dCache_2 k59_1765147_1 247633.GP2143_09295 1.02e-53 192.0 COG0154@1|root,COG0154@2|Bacteria,1MW3Z@1224|Proteobacteria,1RP33@1236|Gammaproteobacteria,1J6AR@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J COG0154 Asp-tRNAAsn Glu-tRNAGln amidotransferase A subunit and related amidases - - 6.3.5.6,6.3.5.7 ko:K02433 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - Amidase k59_1143525_2 1403819.BATR01000081_gene2306 1.35e-10 63.2 COG4322@1|root,COG4322@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - CHAP,PG_binding_1 k59_296987_1 1131269.AQVV01000004_gene587 7.28e-43 147.0 COG0107@1|root,COG0107@2|Bacteria 2|Bacteria E imidazoleglycerol-phosphate synthase activity hisF GO:0000107,GO:0003674,GO:0003824,GO:0016740,GO:0016757,GO:0016763 - ko:K02500 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04558 RC00010,RC01190,RC01943 ko00000,ko00001,ko00002,ko01000 - - - His_biosynth k59_578811_1 314287.GB2207_07836 2.19e-89 272.0 COG0002@1|root,COG0002@2|Bacteria,1MVJ6@1224|Proteobacteria,1RNMX@1236|Gammaproteobacteria,1J549@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde argC GO:0003674,GO:0003824,GO:0003942,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016491,GO:0016620,GO:0016903,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.2.1.38 ko:K00145 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028,M00845 R03443 RC00684 ko00000,ko00001,ko00002,ko01000 - - iSSON_1240.SSON_4131 Semialdhyde_dh,Semialdhyde_dhC k59_635307_1 616991.JPOO01000001_gene3980 1.88e-51 176.0 COG1012@1|root,COG1012@2|Bacteria,4NEB7@976|Bacteroidetes,1HXNG@117743|Flavobacteriia,23H0G@178469|Arenibacter 976|Bacteroidetes C Aldehyde dehydrogenase family sad - 1.2.1.16,1.2.1.20,1.2.1.3,1.2.1.79 ko:K00128,ko:K00135 ko00010,ko00053,ko00071,ko00250,ko00280,ko00310,ko00330,ko00340,ko00350,ko00380,ko00410,ko00561,ko00620,ko00625,ko00650,ko00760,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00250,map00280,map00310,map00330,map00340,map00350,map00380,map00410,map00561,map00620,map00625,map00650,map00760,map00903,map00981,map01100,map01110,map01120,map01130 M00027,M00135 R00264,R00631,R00710,R00713,R00714,R00904,R01752,R01986,R02401,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146 RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_635307_2 1121007.AUML01000051_gene3158 3.65e-36 126.0 COG4980@1|root,COG4980@2|Bacteria,4PK92@976|Bacteroidetes,1IC58@117743|Flavobacteriia,2YM05@290174|Aquimarina 976|Bacteroidetes S YtxH-like protein - - - - - - - - - - - - YtxH k59_14338_1 748658.KB907312_gene1284 1.52e-212 595.0 COG2048@1|root,COG2048@2|Bacteria,1R97P@1224|Proteobacteria,1SJXJ@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Cysteine-rich domain - - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 ko:K03389 ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200 M00356,M00357,M00563,M00567 R04540,R11928,R11931,R11943,R11944 RC00011 ko00000,ko00001,ko00002,ko01000 - - - CCG k59_917792_2 1499967.BAYZ01000105_gene3526 2.72e-36 139.0 COG0706@1|root,COG0706@2|Bacteria,2NP6C@2323|unclassified Bacteria 2|Bacteria U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins yidC GO:0002790,GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006457,GO:0006810,GO:0008104,GO:0008150,GO:0008565,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0016043,GO:0022607,GO:0031224,GO:0031226,GO:0032940,GO:0032977,GO:0033036,GO:0034613,GO:0042886,GO:0043933,GO:0044085,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0046903,GO:0051179,GO:0051205,GO:0051234,GO:0051259,GO:0051260,GO:0051641,GO:0061024,GO:0065003,GO:0070727,GO:0071702,GO:0071705,GO:0071840,GO:0071944,GO:0072657,GO:0090150 - ko:K03217 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044,ko03029 2.A.9 - - 60KD_IMP,YidC_periplas k59_1652618_1 322710.Avin_09050 2.87e-21 88.2 COG0319@1|root,COG0319@2|Bacteria,1MZ67@1224|Proteobacteria,1S6BS@1236|Gammaproteobacteria 1236|Gammaproteobacteria J Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA ybeY GO:0000469,GO:0000478,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0005488,GO:0006139,GO:0006355,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0016072,GO:0016151,GO:0016787,GO:0016788,GO:0016892,GO:0016894,GO:0019219,GO:0019222,GO:0019538,GO:0022613,GO:0030490,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042274,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043244,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0046483,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0071840,GO:0080090,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1903506,GO:2000112,GO:2001141 - ko:K07042 - - - - ko00000,ko03009 - - - UPF0054 k59_805347_1 1443665.JACA01000012_gene1370 3.37e-34 126.0 COG3039@1|root,COG3039@2|Bacteria,4NZF7@976|Bacteroidetes 976|Bacteroidetes L Transposase - - - - - - - - - - - - - k59_805352_2 983545.Glaag_0997 2.02e-16 80.9 COG3590@1|root,COG3590@2|Bacteria,1MVNQ@1224|Proteobacteria,1RNNA@1236|Gammaproteobacteria,464DA@72275|Alteromonadaceae 1236|Gammaproteobacteria O Peptidase, M13 pepO - 3.4.24.71 ko:K01415,ko:K07386 - - - - ko00000,ko01000,ko01002,ko04147 - - - Peptidase_M13,Peptidase_M13_N k59_71264_1 318167.Sfri_0290 1.67e-58 199.0 COG0471@1|root,COG0471@2|Bacteria,1MU0K@1224|Proteobacteria,1RMI1@1236|Gammaproteobacteria,2QAFC@267890|Shewanellaceae 1236|Gammaproteobacteria P TRAP C4-dicarboxylate transport system permease DctM subunit - - - - - - - - - - - - CitMHS,TrkA_C k59_465744_1 1122137.AQXF01000002_gene330 1.92e-81 255.0 COG0305@1|root,COG0305@2|Bacteria,1MUG9@1224|Proteobacteria,2TSF9@28211|Alphaproteobacteria 28211|Alphaproteobacteria L it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins dnaB - 3.6.4.12 ko:K02314 ko03030,ko04112,map03030,map04112 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB,DnaB_C k59_1547464_7 1158614.I592_02709 3.23e-10 66.6 COG0317@1|root,COG0317@2|Bacteria,1TNYZ@1239|Firmicutes,4HBX7@91061|Bacilli,4AZDD@81852|Enterococcaceae 91061|Bacilli KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance relA GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008728,GO:0008893,GO:0009116,GO:0009117,GO:0009119,GO:0009150,GO:0009259,GO:0009605,GO:0009987,GO:0009991,GO:0015969,GO:0016020,GO:0016740,GO:0016772,GO:0016778,GO:0016787,GO:0016788,GO:0016794,GO:0019637,GO:0019693,GO:0030312,GO:0031667,GO:0033865,GO:0033875,GO:0034032,GO:0034035,GO:0034641,GO:0042278,GO:0042578,GO:0042594,GO:0044237,GO:0044238,GO:0044281,GO:0044464,GO:0046128,GO:0046483,GO:0050896,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:1901068,GO:1901135,GO:1901360,GO:1901564,GO:1901657 2.7.6.5 ko:K00951 ko00230,map00230 - R00429 RC00002,RC00078 ko00000,ko00001,ko01000 - - iYO844.BSU27600 ACT_4,HD_4,RelA_SpoT,TGS k59_79223_1 1366050.N234_27815 5.41e-25 97.8 COG3125@1|root,COG3125@2|Bacteria,1RHE5@1224|Proteobacteria,2VSPQ@28216|Betaproteobacteria,1K8F5@119060|Burkholderiaceae 28216|Betaproteobacteria C Cytochrome O ubiquinol oxidase cyoD - - ko:K02300 ko00190,ko01100,map00190,map01100 M00417 - - ko00000,ko00001,ko00002 3.D.4.5 - - COX4_pro k59_79223_2 460265.Mnod_4774 6.84e-37 133.0 COG3346@1|root,COG3346@2|Bacteria,1MWWG@1224|Proteobacteria,2U0N5@28211|Alphaproteobacteria,1JT9J@119045|Methylobacteriaceae 28211|Alphaproteobacteria S PFAM Surfeit locus 1 family protein surF - - ko:K14998 - - - - ko00000,ko03029 3.D.4.8 - - SURF1 k59_1378120_1 953739.SVEN_1000 5.76e-44 161.0 COG0145@1|root,COG0146@1|root,COG0145@2|Bacteria,COG0146@2|Bacteria,2GIYE@201174|Actinobacteria 201174|Actinobacteria EQ PFAM Hydantoinase oxoprolinase oplA - 3.5.2.9 ko:K01469 ko00480,map00480 - R00251 RC00553 ko00000,ko00001,ko01000 - - iNJ661.Rv0266c Hydant_A_N,Hydantoinase_A,Hydantoinase_B k59_1378120_2 1122137.AQXF01000001_gene3013 4.92e-52 171.0 COG0625@1|root,COG0625@2|Bacteria,1PENB@1224|Proteobacteria,2TRVC@28211|Alphaproteobacteria 28211|Alphaproteobacteria O Glutathione S-transferase gstch9 - 2.5.1.18 ko:K00799 ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418 - R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905 RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944 ko00000,ko00001,ko01000,ko02000 1.A.12.2.2,1.A.12.3.2 - - GST_C,GST_C_2,GST_N_3 k59_134780_1 1125973.JNLC01000010_gene1408 1.06e-32 117.0 COG1917@1|root,COG1917@2|Bacteria 2|Bacteria L Cupin 2, conserved barrel domain protein MA20_40115 - - - - - - - - - - - Cupin_2 k59_472841_1 290398.Csal_1468 4.63e-53 184.0 COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,1RMQ4@1236|Gammaproteobacteria,1XICJ@135619|Oceanospirillales 135619|Oceanospirillales IQ involved in the beta-oxidation of n-alkanoic and n-phenylalkanoic acids fadD - 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding,AMP-binding_C k59_191047_1 477184.KYC_12188 2.91e-82 255.0 COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2VKM4@28216|Betaproteobacteria 28216|Betaproteobacteria C transferase - - - - - - - - - - - - CoA_transf_3 k59_247300_2 1042377.AFPJ01000016_gene155 5.04e-48 161.0 COG1187@1|root,COG1187@2|Bacteria,1MU6M@1224|Proteobacteria,1RQA9@1236|Gammaproteobacteria,46734@72275|Alteromonadaceae 1236|Gammaproteobacteria J Belongs to the pseudouridine synthase RsuA family rsuA GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360 5.4.99.19 ko:K06183 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2,S4 k59_21911_1 870187.Thini_1444 3.53e-24 107.0 COG1034@1|root,COG1034@2|Bacteria,1P8MN@1224|Proteobacteria,1RMUH@1236|Gammaproteobacteria,45ZUB@72273|Thiotrichales 72273|Thiotrichales C NADH-quinone oxidoreductase nuoG - 1.6.5.3 ko:K00336 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Fer2_4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3 k59_21911_2 870187.Thini_1443 4.36e-30 117.0 COG1005@1|root,COG1005@2|Bacteria,1MU2R@1224|Proteobacteria,1RQE9@1236|Gammaproteobacteria,45ZQ9@72273|Thiotrichales 72273|Thiotrichales C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone nuoH - 1.6.5.3 ko:K00337 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - NADHdh k59_134805_1 1458357.BG58_23690 4.26e-49 172.0 COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,2VI6G@28216|Betaproteobacteria,1K1V8@119060|Burkholderiaceae 28216|Betaproteobacteria C Dehydrogenase lpdA - 1.8.1.4 ko:K00382 ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00036,M00307,M00532 R00209,R01221,R01698,R03815,R07618,R08549 RC00004,RC00022,RC00583,RC02742,RC02833,RC02834 br01601,ko00000,ko00001,ko00002,ko01000,ko04147 - - - Biotin_lipoyl,Pyr_redox_2,Pyr_redox_dim k59_134805_2 582744.Msip34_0164 8.47e-64 201.0 COG0120@1|root,COG0120@2|Bacteria,1MVGR@1224|Proteobacteria,2VH27@28216|Betaproteobacteria,2KKDZ@206350|Nitrosomonadales 206350|Nitrosomonadales G Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate - - 5.3.1.6 ko:K01807 ko00030,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167,M00580 R01056 RC00434 ko00000,ko00001,ko00002,ko01000 - - - Rib_5-P_isom_A k59_528628_1 1217718.ALOU01000075_gene4456 3.14e-92 283.0 COG0604@1|root,COG0604@2|Bacteria,1MW2V@1224|Proteobacteria,2VMBC@28216|Betaproteobacteria,1K438@119060|Burkholderiaceae 28216|Betaproteobacteria C COG0604 NADPH quinone reductase and related Zn-dependent oxidoreductases - - 1.6.5.5 ko:K00344 - - - - ko00000,ko01000 - - - ADH_zinc_N k59_528628_2 1207075.PputUW4_02143 1.27e-20 102.0 COG0457@1|root,COG3710@1|root,COG3899@1|root,COG0457@2|Bacteria,COG3710@2|Bacteria,COG3899@2|Bacteria,1QU0J@1224|Proteobacteria,1RY8Z@1236|Gammaproteobacteria 1236|Gammaproteobacteria K transcriptional regulator - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - AAA_16,TPR_8,Trans_reg_C k59_1603669_1 323848.Nmul_A1124 1.88e-38 134.0 COG1952@1|root,COG1952@2|Bacteria,1RI75@1224|Proteobacteria,2VQ1Q@28216|Betaproteobacteria,3734Q@32003|Nitrosomonadales 28216|Betaproteobacteria U One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA secB - - ko:K03071 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044,ko03110 3.A.5 - - SecB k59_1094408_1 349521.HCH_06363 3.81e-07 51.2 COG0635@1|root,COG0635@2|Bacteria,1MU76@1224|Proteobacteria,1RN6I@1236|Gammaproteobacteria,1XH6E@135619|Oceanospirillales 135619|Oceanospirillales H Involved in the biosynthesis of porphyrin-containing compound - - - - - - - - - - - - HemN_C,Radical_SAM k59_1094408_2 399739.Pmen_4158 6.37e-42 144.0 COG0127@1|root,COG0127@2|Bacteria,1MUK5@1224|Proteobacteria,1S27C@1236|Gammaproteobacteria,1YDM9@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria F Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions rdgB GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009141,GO:0009143,GO:0009144,GO:0009146,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0035870,GO:0036220,GO:0036222,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046434,GO:0046483,GO:0046700,GO:0046872,GO:0046983,GO:0047429,GO:0055086,GO:0071704,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576 3.6.1.66 ko:K02428 ko00230,map00230 - R00426,R00720,R01855,R02100,R02720,R03531 RC00002 ko00000,ko00001,ko01000 - - iEC55989_1330.EC55989_3247,iECO111_1330.ECO111_3702,iECSE_1348.ECSE_3222,iECW_1372.ECW_m3212,iEKO11_1354.EKO11_0774,iEcE24377_1341.EcE24377A_3298,iWFL_1372.ECW_m3212 Ham1p_like k59_361496_1 977880.RALTA_A0302 1.05e-17 82.4 COG1116@1|root,COG1116@2|Bacteria,1MUDV@1224|Proteobacteria,2VJXH@28216|Betaproteobacteria,1KG6H@119060|Burkholderiaceae 28216|Betaproteobacteria P abc transporter nasD - - ko:K02049,ko:K15578 ko00910,ko02010,map00910,map02010 M00188,M00438 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.16,3.A.1.16.1,3.A.1.17 - - ABC_tran k59_361496_2 706587.Desti_0199 7.37e-64 199.0 COG1513@1|root,COG1513@2|Bacteria,1R9X0@1224|Proteobacteria 1224|Proteobacteria P Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide cynS - 4.2.1.104 ko:K01725 ko00910,map00910 - R03546,R10079 RC00952 ko00000,ko00001,ko01000 - - - Cyanate_lyase k59_1151223_1 94122.Shewana3_2014 4.67e-37 136.0 COG3221@1|root,COG3221@2|Bacteria,1R4SK@1224|Proteobacteria,1RR7M@1236|Gammaproteobacteria,2QBE7@267890|Shewanellaceae 1236|Gammaproteobacteria P ABC transporter, phosphonate, periplasmic substrate-binding protein - - - ko:K02044 ko02010,map02010 M00223 - - ko00000,ko00001,ko00002,ko02000 3.A.1.9 - - Phosphonate-bd k59_586426_1 1463858.JOHR01000003_gene1844 1.95e-14 72.4 COG2132@1|root,COG2132@2|Bacteria,2GMJ4@201174|Actinobacteria 201174|Actinobacteria Q Multicopper oxidase - - 1.3.3.5 ko:K08100 ko00860,ko01110,map00860,map01110 - R02394 RC01983 ko00000,ko00001,ko01000 - - - Cu-oxidase,Cu-oxidase_2,Cu-oxidase_3 k59_586426_2 225937.HP15_4014 6.22e-38 141.0 COG1233@1|root,COG1233@2|Bacteria,1MV2R@1224|Proteobacteria,1RMGJ@1236|Gammaproteobacteria,46C30@72275|Alteromonadaceae 1236|Gammaproteobacteria Q Flavin containing amine oxidoreductase - - 1.3.99.23 ko:K09516 ko00830,map00830 - R07163 RC01835 ko00000,ko00001,ko01000 - - - Amino_oxidase,FAD_binding_6,NAD_binding_1,NAD_binding_8 k59_870043_2 351746.Pput_3458 2.25e-34 126.0 COG0084@1|root,COG0084@2|Bacteria,1MXN8@1224|Proteobacteria,1RNCC@1236|Gammaproteobacteria,1YUZJ@136845|Pseudomonas putida group 1236|Gammaproteobacteria L PFAM TatD-related deoxyribonuclease tatD GO:0000175,GO:0000302,GO:0000738,GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004529,GO:0004532,GO:0004536,GO:0004540,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006308,GO:0006725,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008296,GO:0008297,GO:0008310,GO:0008408,GO:0009056,GO:0009057,GO:0009636,GO:0009987,GO:0010035,GO:0016070,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0016896,GO:0019439,GO:0034641,GO:0034655,GO:0042221,GO:0042493,GO:0042542,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046677,GO:0046700,GO:0046872,GO:0050896,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0140097,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901700 - ko:K03424 - - - - ko00000,ko01000 - - - TatD_DNase k59_1547520_1 390235.PputW619_0939 4.51e-48 171.0 COG0769@1|root,COG0769@2|Bacteria,1MU6P@1224|Proteobacteria,1RMD6@1236|Gammaproteobacteria,1YWJ3@136845|Pseudomonas putida group 1236|Gammaproteobacteria M Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan murE GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008765,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0030203,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 6.3.2.13 ko:K01928 ko00300,ko00550,map00300,map00550 - R02788 RC00064,RC00090 ko00000,ko00001,ko01000,ko01011 - - iECO103_1326.ECO103_0087,iECO111_1330.ECO111_0088,iECW_1372.ECW_m0084,iEKO11_1354.EKO11_3829,iWFL_1372.ECW_m0084,ic_1306.c0103 Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_1094419_1 935866.JAER01000040_gene520 7.47e-25 108.0 COG0840@1|root,COG0840@2|Bacteria 2|Bacteria NT transmembrane signaling receptor activity - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - GAF_2,HAMP,MCPsignal,PAS_3,PAS_4 k59_1151239_1 1137269.AZWL01000001_gene6023 6.41e-06 53.5 COG0683@1|root,COG0683@2|Bacteria,2GMCF@201174|Actinobacteria 201174|Actinobacteria E ABC-type branched-chain amino acid transport bra - - - - - - - - - - - Peripla_BP_6 k59_925079_2 861208.AGROH133_08864 2.49e-35 125.0 COG2009@1|root,COG2009@2|Bacteria,1N02N@1224|Proteobacteria,2UC47@28211|Alphaproteobacteria,4BE7X@82115|Rhizobiaceae 28211|Alphaproteobacteria C succinate dehydrogenase sdhC GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K00241 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00149,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002 - - - Sdh_cyt k59_925079_3 1122137.AQXF01000007_gene3526 4.65e-71 215.0 COG2142@1|root,COG2142@2|Bacteria,1MZND@1224|Proteobacteria,2UC3G@28211|Alphaproteobacteria 28211|Alphaproteobacteria C succinate dehydrogenase sdhD - - ko:K00242 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00149,M00173 R02164 RC00045 ko00000,ko00001,ko00002 - - - Sdh_cyt k59_925079_4 1122137.AQXF01000007_gene3525 1.49e-39 144.0 COG1053@1|root,COG1053@2|Bacteria,1MU5M@1224|Proteobacteria,2TQJA@28211|Alphaproteobacteria 28211|Alphaproteobacteria C Belongs to the FAD-dependent oxidoreductase 2 family. FRD SDH subfamily sdhA - 1.3.5.1,1.3.5.4 ko:K00239 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134 M00009,M00011,M00149,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_2,Succ_DH_flav_C k59_304912_1 342949.PNA2_1341 2.27e-75 238.0 COG0473@1|root,arCOG01163@2157|Archaea,2XT99@28890|Euryarchaeota,242YH@183968|Thermococci 183968|Thermococci C Isocitrate/isopropylmalate dehydrogenase - - 1.1.1.85 ko:K00052 ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230 M00432,M00535 R00994,R04426,R10052 RC00084,RC00417,RC03036 br01601,ko00000,ko00001,ko00002,ko01000 - - - Iso_dh k59_1603698_1 316407.85676179 7.07e-145 416.0 COG2942@1|root,COG2942@2|Bacteria,1MX1J@1224|Proteobacteria,1RSCF@1236|Gammaproteobacteria,3XQXT@561|Escherichia 1236|Gammaproteobacteria G Catalyzes the isomerization of sulfoquinovose (SQ) to 6- deoxy-6-sulfo-D-fructose (SF) yihS GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006066,GO:0006082,GO:0006790,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016054,GO:0016853,GO:0016860,GO:0016861,GO:0019637,GO:0034308,GO:0042180,GO:0042802,GO:0044237,GO:0044248,GO:0044273,GO:0044281,GO:0044282,GO:0050089,GO:0061593,GO:0061720,GO:0071704,GO:1901135,GO:1901136,GO:1901575,GO:1901615,GO:1902776,GO:1902777 5.3.1.31 ko:K18479 - - R10765 RC00376 ko00000,ko01000 - - - GlcNAc_2-epim k59_870062_1 754476.Q7A_2829 3.79e-77 241.0 COG1686@1|root,COG1686@2|Bacteria,1MUU7@1224|Proteobacteria,1RMJA@1236|Gammaproteobacteria,4602E@72273|Thiotrichales 72273|Thiotrichales M Belongs to the peptidase S11 family - - 3.4.16.4 ko:K07258 ko00550,ko01100,map00550,map01100 - - - ko00000,ko00001,ko01000,ko01002,ko01011 - - - PBP5_C,Peptidase_S11 k59_1151248_1 666685.R2APBS1_2880 3.87e-54 178.0 COG3647@1|root,COG3647@2|Bacteria,1N7NB@1224|Proteobacteria,1S57E@1236|Gammaproteobacteria,1XC9D@135614|Xanthomonadales 135614|Xanthomonadales S Predicted membrane protein (DUF2238) - - - ko:K08984 - - - - ko00000 - - - DUF2238 k59_134846_1 2002.JOEQ01000024_gene184 1.7e-49 172.0 COG0682@1|root,COG0682@2|Bacteria,2GKSS@201174|Actinobacteria,4EFIS@85012|Streptosporangiales 201174|Actinobacteria M Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins lgt - - - - - - - - - - - LGT k59_1603712_1 1415778.JQMM01000001_gene782 4.07e-45 155.0 COG1704@1|root,COG1704@2|Bacteria,1RDUH@1224|Proteobacteria,1S2KR@1236|Gammaproteobacteria,1J6CD@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S E3 Ubiquitin ligase - - - - - - - - - - - - GIDE k59_1603712_2 1122599.AUGR01000013_gene746 5.76e-22 90.1 COG1704@1|root,COG1704@2|Bacteria,1R9YG@1224|Proteobacteria,1T06D@1236|Gammaproteobacteria 1236|Gammaproteobacteria S LemA family lemA - - ko:K03744 - - - - ko00000 - - - LemA k59_699643_1 493475.GARC_4724 1.22e-218 613.0 COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,1RMBQ@1236|Gammaproteobacteria 1236|Gammaproteobacteria C belongs to the aldehyde dehydrogenase family - - 1.2.1.3 ko:K00128 ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130 M00135 R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146 RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_699643_2 42565.FP66_04965 9.64e-30 110.0 COG3805@1|root,COG3805@2|Bacteria,1N2DN@1224|Proteobacteria,1SA51@1236|Gammaproteobacteria 1236|Gammaproteobacteria Q COG3805 Aromatic ring-cleaving dioxygenase - - - ko:K10253 - - - - ko00000,ko01000 - - - DOPA_dioxygen k59_699643_3 1122612.AUBA01000006_gene2499 5.09e-49 163.0 COG4689@1|root,COG4689@2|Bacteria,1RC8T@1224|Proteobacteria,2U7NV@28211|Alphaproteobacteria,2KB59@204457|Sphingomonadales 204457|Sphingomonadales Q Acetoacetate decarboxylase (ADC) - - - - - - - - - - - - ADC k59_1263516_1 1009370.ALO_09489 6.41e-34 129.0 COG1171@1|root,COG1171@2|Bacteria,1TP22@1239|Firmicutes,4H1WE@909932|Negativicutes 909932|Negativicutes E threonine ilvA - 4.3.1.19 ko:K01754 ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230 M00570 R00220,R00996 RC00418,RC02600 ko00000,ko00001,ko00002,ko01000 - - - ACT_4,PALP k59_1208116_1 748658.KB907312_gene1273 2.77e-86 265.0 COG2516@1|root,COG2516@2|Bacteria,1MWZQ@1224|Proteobacteria,1RY3C@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Radical SAM - - 2.8.1.6 ko:K01012 ko00780,ko01100,map00780,map01100 M00123,M00573,M00577 R01078 RC00441 ko00000,ko00001,ko00002,ko01000 - - - Radical_SAM k59_1208117_1 1071679.BG57_00970 7.95e-33 122.0 COG1117@1|root,COG1117@2|Bacteria,1MU16@1224|Proteobacteria,2VI4J@28216|Betaproteobacteria,1JZYI@119060|Burkholderiaceae 28216|Betaproteobacteria P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system pstB - 3.6.3.27 ko:K02036 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.7 - - ABC_tran k59_1208117_2 1301098.PKB_3484 5.39e-51 169.0 COG0581@1|root,COG0581@2|Bacteria,1MUWB@1224|Proteobacteria,1RPV9@1236|Gammaproteobacteria 1236|Gammaproteobacteria P phosphate transport system permease pstA - - ko:K02038 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - iJN746.PP_2658,iPC815.YPO4115,iYL1228.KPN_04131,iZ_1308.Z5217 BPD_transp_1 k59_361543_1 314264.ROS217_16376 1.68e-49 169.0 COG0697@1|root,COG0697@2|Bacteria,1RFZW@1224|Proteobacteria,2TRXD@28211|Alphaproteobacteria,46QFK@74030|Roseovarius 28211|Alphaproteobacteria EG COG0697 Permeases of the drug metabolite transporter (DMT) superfamily - - - - - - - - - - - - EamA k59_870083_1 748247.AZKH_0352 2.67e-65 210.0 COG2010@1|root,COG2010@2|Bacteria,1R48P@1224|Proteobacteria,2VPF4@28216|Betaproteobacteria 28216|Betaproteobacteria C Cytochrome C oxidase, cbb3-type, subunit III - - - ko:K00406 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00156 - - ko00000,ko00001,ko00002 3.D.4.3 - - Cytochrome_CBB3 k59_1320852_1 67257.JODR01000031_gene495 8.78e-21 90.9 COG2141@1|root,COG2141@2|Bacteria,2HVKH@201174|Actinobacteria 201174|Actinobacteria C Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases - - - - - - - - - - - - Bac_luciferase k59_1716526_1 1169143.KB911055_gene2513 3.44e-54 180.0 COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,2VJ5H@28216|Betaproteobacteria,1K2CZ@119060|Burkholderiaceae 28216|Betaproteobacteria L transposase IS116 IS110 IS902 family - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_304941_1 566466.NOR53_3013 2.74e-50 172.0 COG1071@1|root,COG1071@2|Bacteria,1MU5R@1224|Proteobacteria,1SMZY@1236|Gammaproteobacteria,1J7SN@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C C COG1071 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit - - - - - - - - - - - - E1_dh k59_1094451_2 436308.Nmar_1301 8.45e-39 135.0 COG1339@1|root,arCOG01904@2157|Archaea,41SG9@651137|Thaumarchaeota 651137|Thaumarchaeota H Domain of unknown function DUF120 - - 2.7.1.161 ko:K07732 ko00740,ko01100,map00740,map01100 - R08574 RC00002,RC00017 ko00000,ko00001,ko01000 - - - CTP-dep_RFKase k59_1320857_1 436308.Nmar_1182 6.79e-118 348.0 COG0513@1|root,arCOG00558@2157|Archaea,41SM1@651137|Thaumarchaeota 651137|Thaumarchaeota L DEAD DEAH box helicase - - 3.6.4.13 ko:K05592 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03009,ko03019 - - - DEAD,Helicase_C k59_1491349_1 1100721.ALKO01000003_gene2156 0.00012 45.1 COG0566@1|root,COG0566@2|Bacteria,1R9JA@1224|Proteobacteria,2VQDG@28216|Betaproteobacteria,4AAP3@80864|Comamonadaceae 28216|Betaproteobacteria J tRNA rRNA methyltransferase, SpoU spoU - - ko:K03437 - - - - ko00000,ko03016 - - - SpoU_methylase k59_1491349_2 319224.Sputcn32_1361 3.48e-38 143.0 COG0763@1|root,COG0763@2|Bacteria,1MVBI@1224|Proteobacteria,1RNS1@1236|Gammaproteobacteria,2Q9BM@267890|Shewanellaceae 1236|Gammaproteobacteria M Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell lpxB GO:0003674,GO:0003824,GO:0005488,GO:0005543,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008194,GO:0008289,GO:0008610,GO:0008654,GO:0008915,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0019637,GO:0019897,GO:0019898,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0046467,GO:0046493,GO:0071704,GO:0071944,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 2.4.1.182 ko:K00748 ko00540,ko01100,map00540,map01100 M00060 R04606 RC00005,RC00059 ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT19 iE2348C_1286.E2348C_0187,iEcolC_1368.EcolC_3478 LpxB k59_1716535_1 29581.BW37_05282 3.93e-10 58.2 COG0317@1|root,COG0317@2|Bacteria,1N2BZ@1224|Proteobacteria 1224|Proteobacteria KT HD domain relA_2 - - - - - - - - - - - HD_4 k59_472906_1 1298920.KI911353_gene1997 4.93e-35 135.0 COG1012@1|root,COG1012@2|Bacteria,1TRGK@1239|Firmicutes,2480V@186801|Clostridia,21XFW@1506553|Lachnoclostridium 186801|Clostridia C Aldehyde dehydrogenase family eutE - 1.2.1.10,1.2.1.87 ko:K00132,ko:K13922 ko00620,ko00640,ko00650,ko01100,ko01120,map00620,map00640,map00650,map01100,map01120 - R00228,R01172,R09097 RC00004,RC00184,RC01195 ko00000,ko00001,ko01000 - - - Aldedh k59_472906_2 215803.DB30_1142 3.22e-18 77.8 COG4576@1|root,COG4576@2|Bacteria,1RIK4@1224|Proteobacteria,4362N@68525|delta/epsilon subdivisions,2X9F2@28221|Deltaproteobacteria,2Z246@29|Myxococcales 28221|Deltaproteobacteria CQ Ethanolamine utilisation protein EutN/carboxysome - - - - - - - - - - - - EutN_CcmL k59_191109_1 330214.NIDE0719 4.84e-70 223.0 28IX1@1|root,2Z8V3@2|Bacteria 2|Bacteria S Protein of unknown function (DUF2914) - - - - - - - - - - - - DUF2914 k59_361562_1 1394178.AWOO02000001_gene1443 7.89e-43 152.0 COG0346@1|root,COG0346@2|Bacteria,2GN2E@201174|Actinobacteria 201174|Actinobacteria E Glyoxalase bleomycin resistance protein dioxygenase - - - - - - - - - - - - Glyoxalase k59_361562_2 1280950.HJO_16065 2.37e-106 318.0 COG0179@1|root,COG0179@2|Bacteria,1MUPF@1224|Proteobacteria,2TQQG@28211|Alphaproteobacteria 28211|Alphaproteobacteria Q COG0179 2-keto-4-pentenoate hydratase 2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) - - - - - - - - - - - - DUF2437,FAA_hydrolase k59_1378227_1 59374.Fisuc_1805 7.44e-54 191.0 COG0060@1|root,COG0060@2|Bacteria 2|Bacteria J isoleucyl-tRNA aminoacylation ileS GO:0003674,GO:0003824,GO:0004812,GO:0004822,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006428,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0030312,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.5 ko:K01870 ko00970,map00970 M00359,M00360 R03656 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,tRNA-synt_1 k59_247393_1 330214.NIDE1016 3.97e-50 177.0 COG0768@1|root,COG0768@2|Bacteria,3J0FY@40117|Nitrospirae 40117|Nitrospirae M Penicillin-binding Protein dimerisation domain - - 3.4.16.4 ko:K05515 ko00550,ko01501,map00550,map01501 - - - ko00000,ko00001,ko01000,ko01011 - - - PBP_dimer,Transpeptidase k59_1772154_1 1122137.AQXF01000002_gene116 2.56e-96 289.0 COG1005@1|root,COG1005@2|Bacteria,1MU2R@1224|Proteobacteria,2TS09@28211|Alphaproteobacteria 28211|Alphaproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone nuoH GO:0003674,GO:0003824,GO:0003954,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0016655,GO:0050136,GO:0055114 1.6.5.3 ko:K00337 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - NADHdh k59_1772154_2 1122137.AQXF01000002_gene117 8.8e-09 54.3 COG1143@1|root,COG1143@2|Bacteria,1MV90@1224|Proteobacteria,2TRFE@28211|Alphaproteobacteria 28211|Alphaproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoI GO:0003674,GO:0003824,GO:0003954,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0016655,GO:0050136,GO:0055114 1.6.5.3,1.6.99.3 ko:K00338,ko:K03941 ko00190,ko01100,ko04714,ko04723,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map04714,map04723,map04932,map05010,map05012,map05016 M00143,M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1,3.D.1.6 - - Fer4 k59_136313_1 292.DM42_2784 4.43e-18 82.4 COG2872@1|root,COG2872@2|Bacteria,1MY0P@1224|Proteobacteria,2VMEB@28216|Betaproteobacteria,1K3AR@119060|Burkholderiaceae 28216|Betaproteobacteria S Threonyl alanyl tRNA synthetase alaS_2 - - ko:K07050 - - - - ko00000,ko01000,ko03016 - - - tRNA-synt_2c,tRNA_SAD k59_136313_2 1122135.KB893134_gene3485 1.26e-35 130.0 COG3427@1|root,COG3427@2|Bacteria,1RHUC@1224|Proteobacteria,2U9HD@28211|Alphaproteobacteria 28211|Alphaproteobacteria S carbon monoxide dehydrogenase coxG - - ko:K09386 - - - - ko00000 - - - COXG k59_871537_1 1121921.KB898708_gene1531 4.77e-11 63.2 COG0272@1|root,COG0272@2|Bacteria,1MV3R@1224|Proteobacteria,1RPAV@1236|Gammaproteobacteria,2PMTW@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria L breast cancer carboxy-terminal domain ligA GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003909,GO:0003911,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016874,GO:0016886,GO:0033554,GO:0034641,GO:0034645,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050662,GO:0050896,GO:0051103,GO:0051287,GO:0051716,GO:0070403,GO:0071704,GO:0090304,GO:0097159,GO:0140097,GO:1901265,GO:1901360,GO:1901363,GO:1901576 6.5.1.2 ko:K01972 ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430 - R00382 RC00005 ko00000,ko00001,ko01000,ko03032,ko03400 - - iEC55989_1330.EC55989_2701,iECABU_c1320.ECABU_c27320,iECIAI1_1343.ECIAI1_2469,iECO103_1326.ECO103_2930,iECO111_1330.ECO111_3141,iECO26_1355.ECO26_3464,iECSE_1348.ECSE_2702,iECW_1372.ECW_m2640,iEKO11_1354.EKO11_1317,iEcE24377_1341.EcE24377A_2698,iEcSMS35_1347.EcSMS35_2566,iWFL_1372.ECW_m2640,iYL1228.KPN_02758,ic_1306.c2945 BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5 k59_871537_2 247633.GP2143_07494 1.18e-35 129.0 COG3115@1|root,COG3115@2|Bacteria,1MVHR@1224|Proteobacteria,1RMDB@1236|Gammaproteobacteria,1J5TI@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria D Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring. Also required for the recruitment to the septal ring of downstream cell division proteins zipA GO:0000278,GO:0000281,GO:0000910,GO:0000917,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0007049,GO:0008150,GO:0009987,GO:0016020,GO:0016021,GO:0016043,GO:0022402,GO:0022607,GO:0031224,GO:0031226,GO:0032153,GO:0032506,GO:0044085,GO:0044425,GO:0044459,GO:0044464,GO:0051301,GO:0061640,GO:0071840,GO:0071944,GO:0090529,GO:1902410,GO:1903047 - ko:K03528 - - - - ko00000,ko03036 - - - ZipA_C k59_643536_1 1229909.NSED_02565 1.87e-32 119.0 COG1648@1|root,arCOG01044@2157|Archaea,41SN9@651137|Thaumarchaeota 651137|Thaumarchaeota H Siroheme synthase - - 1.3.1.76,4.99.1.4 ko:K02304 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R02864,R03947 RC01012,RC01034 ko00000,ko00001,ko00002,ko01000 - - - NAD_binding_7,Sirohm_synth_M k59_643536_2 436308.Nmar_0510 1.14e-108 324.0 COG0373@1|root,arCOG01036@2157|Archaea,41SDM@651137|Thaumarchaeota 651137|Thaumarchaeota H Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) - - 1.2.1.70 ko:K02492 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R04109 RC00055,RC00149 ko00000,ko00001,ko00002,ko01000 - - - GlutR_N,GlutR_dimer,Shikimate_DH k59_981643_1 1122921.KB898190_gene1545 9.39e-14 75.1 COG0745@1|root,COG2199@1|root,COG0745@2|Bacteria,COG3706@2|Bacteria,1TSW8@1239|Firmicutes,4HBT1@91061|Bacilli,26U8D@186822|Paenibacillaceae 91061|Bacilli T Diguanylate cyclase, GGDEF domain - - - - - - - - - - - - GGDEF,Hpt,Response_reg k59_871539_1 641491.DND132_2087 7.56e-44 157.0 COG5323@1|root,COG5323@2|Bacteria,1R049@1224|Proteobacteria,42UYF@68525|delta/epsilon subdivisions,2WQN3@28221|Deltaproteobacteria,2M90K@213115|Desulfovibrionales 28221|Deltaproteobacteria S Terminase RNaseH-like domain - - - - - - - - - - - - Terminase_6 k59_473910_1 545264.KB898745_gene1134 2.45e-107 340.0 COG1197@1|root,COG1197@2|Bacteria,1MUXG@1224|Proteobacteria,1RNCU@1236|Gammaproteobacteria,1WWJQ@135613|Chromatiales 135613|Chromatiales L Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site mfd - - ko:K03723 ko03420,map03420 - - - ko00000,ko00001,ko01000,ko03400 - - - CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF k59_23419_1 1123504.JQKD01000005_gene4791 9.32e-65 221.0 COG4770@1|root,COG4770@2|Bacteria,1P6RE@1224|Proteobacteria,2VJHH@28216|Betaproteobacteria,4AC5B@80864|Comamonadaceae 28216|Betaproteobacteria I Carbamoyl-phosphate synthase L chain, ATP-binding - - 6.4.1.4,6.4.1.5 ko:K01968,ko:K13777 ko00280,ko00281,ko01100,map00280,map00281,map01100 M00036 R03494,R04138 RC00367,RC00942 ko00000,ko00001,ko00002,ko01000 - - - Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2 k59_1549092_1 1267533.KB906739_gene2793 1.2e-78 247.0 COG1012@1|root,COG1012@2|Bacteria,3Y2Q5@57723|Acidobacteria 57723|Acidobacteria C PFAM Aldehyde dehydrogenase - - 1.2.1.16,1.2.1.20,1.2.1.79 ko:K00135 ko00250,ko00310,ko00350,ko00650,ko00760,ko01100,ko01120,map00250,map00310,map00350,map00650,map00760,map01100,map01120 M00027 R00713,R00714,R02401 RC00080 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_701112_1 443143.GM18_2525 3.11e-33 135.0 COG0645@1|root,COG2187@1|root,COG0645@2|Bacteria,COG2187@2|Bacteria,1MU9M@1224|Proteobacteria,42NEZ@68525|delta/epsilon subdivisions,2WJ5R@28221|Deltaproteobacteria,43U4X@69541|Desulfuromonadales 28221|Deltaproteobacteria S AAA domain - - - ko:K07028 - - - - ko00000 - - - AAA_33,APH k59_1773022_1 983917.RGE_39420 0.000399 50.4 COG0784@1|root,COG2202@1|root,COG4251@1|root,COG5000@1|root,COG0784@2|Bacteria,COG2202@2|Bacteria,COG4251@2|Bacteria,COG5000@2|Bacteria,1NC9X@1224|Proteobacteria,2WHTA@28216|Betaproteobacteria 28216|Betaproteobacteria T PAS fold - - - - - - - - - - - - HATPase_c,HisKA,PAS_4,PAS_7,Response_reg k59_1506169_2 1161401.ASJA01000004_gene2187 5.06e-49 166.0 COG1344@1|root,COG1344@2|Bacteria,1MV1N@1224|Proteobacteria,2TUQQ@28211|Alphaproteobacteria,43XBV@69657|Hyphomonadaceae 28211|Alphaproteobacteria N Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella flaA GO:0005575,GO:0005576,GO:0005623,GO:0009288,GO:0042995,GO:0043226,GO:0043228,GO:0044464 - ko:K02406 ko02020,ko02040,ko04621,ko04626,ko05132,ko05134,map02020,map02040,map04621,map04626,map05132,map05134 - - - ko00000,ko00001,ko02035 - - - Flagellin_C,Flagellin_N k59_36896_1 1229909.NSED_01405 3.33e-17 80.5 COG0750@1|root,arCOG00609@2157|Archaea,41S8V@651137|Thaumarchaeota 651137|Thaumarchaeota M Peptidase family M50 - - - - - - - - - - - - Peptidase_M50 k59_884961_1 933262.AXAM01000020_gene46 9.15e-30 122.0 COG1262@1|root,COG4249@1|root,COG1262@2|Bacteria,COG4249@2|Bacteria,1NQ5K@1224|Proteobacteria,42MAT@68525|delta/epsilon subdivisions,2WKY9@28221|Deltaproteobacteria,2MIBZ@213118|Desulfobacterales 28221|Deltaproteobacteria S Caspase domain - - - - - - - - - - - - FGE-sulfatase,PEGA,Peptidase_C14 k59_483326_1 987059.RBXJA2T_19636 2.29e-27 113.0 COG0477@1|root,COG2814@2|Bacteria,1QUTR@1224|Proteobacteria,2VHHN@28216|Betaproteobacteria,1KK4R@119065|unclassified Burkholderiales 28216|Betaproteobacteria EGP Major Facilitator Superfamily - - - - - - - - - - - - MFS_1,Sugar_tr k59_1164763_1 640081.Dsui_1322 1.14e-57 191.0 COG0541@1|root,COG0541@2|Bacteria,1MVIA@1224|Proteobacteria,2VJ3W@28216|Betaproteobacteria,2KUVT@206389|Rhodocyclales 206389|Rhodocyclales U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components ffh - 3.6.5.4 ko:K03106 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko01000,ko02044 3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9 - - SRP54,SRP54_N,SRP_SPB k59_538503_2 1122137.AQXF01000002_gene428 1.18e-07 52.4 COG1171@1|root,COG1171@2|Bacteria,1MVWJ@1224|Proteobacteria,2TQN9@28211|Alphaproteobacteria 28211|Alphaproteobacteria E threonine dehydratase ilvA - 4.3.1.19 ko:K01754 ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230 M00570 R00220,R00996 RC00418,RC02600 ko00000,ko00001,ko00002,ko01000 - - - ACT,ACT_4,PALP k59_1393189_1 1229909.NSED_00425 3.48e-25 115.0 COG0642@1|root,arCOG02358@2157|Archaea 2157|Archaea T Histidine kinase - - - - - - - - - - - - HATPase_c,HisKA k59_1563574_1 391603.FBALC1_01502 6.87e-39 130.0 2E6VD@1|root,331EZ@2|Bacteria,4NUSW@976|Bacteroidetes,1I3VV@117743|Flavobacteriia 976|Bacteroidetes S Protein of unknown function (DUF3098) fjo13 - - - - - - - - - - - DUF3098 k59_1563574_2 1484460.JSWG01000009_gene433 3.97e-62 197.0 COG1968@1|root,COG1968@2|Bacteria,4NGIZ@976|Bacteroidetes,1HWSY@117743|Flavobacteriia 976|Bacteroidetes V Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin uppP - 3.6.1.27 ko:K06153 ko00550,map00550 - R05627 RC00002 ko00000,ko00001,ko01000,ko01011 - - - BacA k59_1671263_1 1122137.AQXF01000003_gene2412 2.1e-52 170.0 COG0219@1|root,COG0219@2|Bacteria,1RCY4@1224|Proteobacteria,2U78W@28211|Alphaproteobacteria 28211|Alphaproteobacteria J Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide trmL - 2.1.1.207 ko:K03216 - - - - ko00000,ko01000,ko03016 - - - SpoU_methylase k59_92725_1 765913.ThidrDRAFT_4551 8.69e-54 181.0 COG0842@1|root,COG0842@2|Bacteria,1MW5R@1224|Proteobacteria,1RPB4@1236|Gammaproteobacteria,1WXQP@135613|Chromatiales 135613|Chromatiales U PFAM ABC-2 type transporter - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_3 k59_92725_2 566466.NOR53_545 7.13e-55 188.0 COG1020@1|root,COG1020@2|Bacteria,1N7HY@1224|Proteobacteria,1RZG3@1236|Gammaproteobacteria,1J5K2@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria Q Protein of unknown function (DUF1298) - - - - - - - - - - - - DUF1298,WES_acyltransf k59_36930_1 474922.ELA29430 1.44e-05 52.4 COG0666@1|root,KOG4177@2759|Eukaryota,38BVK@33154|Opisthokonta,3P1A7@4751|Fungi,3QTGD@4890|Ascomycota,21592@147550|Sordariomycetes,1F4QP@1028384|Glomerellales 4751|Fungi M Ankyrin repeats (many copies) - - - - - - - - - - - - Ank_2,Ank_3,Ank_4 k59_601446_1 1229909.NSED_01115 3.11e-64 200.0 arCOG00552@1|root,arCOG00552@2157|Archaea,41SRW@651137|Thaumarchaeota 651137|Thaumarchaeota L GINS complex protein - - - ko:K09723 - - - - ko00000,ko03032 - - - Sld5 k59_1781373_1 1217712.F971_00621 6.11e-22 96.3 COG2834@1|root,COG2834@2|Bacteria,1PXDV@1224|Proteobacteria,1RYHF@1236|Gammaproteobacteria,3NKC7@468|Moraxellaceae 1236|Gammaproteobacteria M Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) lolA - - ko:K03634 - - - - ko00000 - - - LolA k59_1729185_1 913325.N799_11010 1.87e-61 211.0 COG0612@1|root,COG0612@2|Bacteria,1MVST@1224|Proteobacteria,1RN05@1236|Gammaproteobacteria,1X39C@135614|Xanthomonadales 135614|Xanthomonadales S Peptidase M16 - - - - - - - - - - - - Peptidase_M16,Peptidase_M16_C k59_36941_1 1415778.JQMM01000001_gene820 5.79e-54 184.0 COG0471@1|root,COG0569@1|root,COG0471@2|Bacteria,COG0569@2|Bacteria,1MU0K@1224|Proteobacteria,1RMI1@1236|Gammaproteobacteria,1J4XJ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P COG0471 Di- and tricarboxylate transporters - - - - - - - - - - - - CitMHS,TrkA_C k59_36941_2 1177181.T9A_02206 7.69e-78 242.0 COG0530@1|root,COG0530@2|Bacteria,1MU3R@1224|Proteobacteria,1RMRD@1236|Gammaproteobacteria,1XHJ1@135619|Oceanospirillales 135619|Oceanospirillales P antiporter - - - ko:K07301 - - - - ko00000,ko02000 2.A.19.5 - - Na_Ca_ex k59_1393225_1 1122137.AQXF01000002_gene410 3.56e-122 361.0 COG1377@1|root,COG1377@2|Bacteria,1MUWI@1224|Proteobacteria,2TS13@28211|Alphaproteobacteria 28211|Alphaproteobacteria N Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin flhB - - ko:K02401 ko02040,map02040 - - - ko00000,ko00001,ko02035,ko02044 3.A.6.2 - - Bac_export_2 k59_1393225_2 1122137.AQXF01000002_gene409 5.64e-16 79.0 COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TQQ9@28211|Alphaproteobacteria 28211|Alphaproteobacteria T Histidine kinase cckA - 2.7.13.3 ko:K13587 ko02020,ko04112,map02020,map04112 M00512 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA,PAS,PAS_4,PAS_8,PAS_9,Response_reg k59_1221104_1 1298867.AUES01000005_gene109 1.27e-07 58.9 COG2114@1|root,COG3899@1|root,COG2114@2|Bacteria,COG3899@2|Bacteria,1MUDT@1224|Proteobacteria,2TQVN@28211|Alphaproteobacteria,3JTQ7@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria T Adenylate and Guanylate cyclase catalytic domain - - - - - - - - - - - - AAA_16,DZR,Guanylate_cyc,SAM_1 k59_601463_1 63737.Npun_R4172 1.15e-75 242.0 COG0500@1|root,COG2226@2|Bacteria,1G36P@1117|Cyanobacteria,1HS5I@1161|Nostocales 1117|Cyanobacteria Q PFAM Methyltransferase type 11 - - - - - - - - - - - - Methyltransf_25 k59_885014_1 1167006.UWK_00364 3.52e-40 140.0 COG0526@1|root,COG0526@2|Bacteria,1N726@1224|Proteobacteria,42U61@68525|delta/epsilon subdivisions,2WQRF@28221|Deltaproteobacteria 28221|Deltaproteobacteria CO alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen resA - - - - - - - - - - - AhpC-TSA k59_885014_2 589865.DaAHT2_1424 4.89e-37 129.0 COG0203@1|root,COG0203@2|Bacteria,1RCWN@1224|Proteobacteria,42SBD@68525|delta/epsilon subdivisions,2WP9P@28221|Deltaproteobacteria,2MKCX@213118|Desulfobacterales 28221|Deltaproteobacteria J PFAM ribosomal protein L17 rplQ GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - ko:K02879 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L17 k59_885014_3 335543.Sfum_1582 5.24e-77 240.0 COG0202@1|root,COG0202@2|Bacteria,1MU75@1224|Proteobacteria,42MIX@68525|delta/epsilon subdivisions,2WJ5K@28221|Deltaproteobacteria,2MR47@213462|Syntrophobacterales 28221|Deltaproteobacteria K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoA GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006351,GO:0006354,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576 2.7.7.6 ko:K03040 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_A_CTD,RNA_pol_A_bac,RNA_pol_L k59_320123_1 1407650.BAUB01000011_gene2035 5.91e-100 297.0 COG3384@1|root,COG3384@2|Bacteria,1GPGA@1117|Cyanobacteria,1H36B@1129|Synechococcus 1117|Cyanobacteria S Catalytic LigB subunit of aromatic ring-opening dioxygenase - - - ko:K15777 ko00965,map00965 - R08836 RC00387 ko00000,ko00001,ko01000 - - - LigB k59_1221111_1 555793.WSK_0820 3.08e-120 348.0 COG0726@1|root,COG0726@2|Bacteria,1MV3V@1224|Proteobacteria,2TR0I@28211|Alphaproteobacteria,2K21Q@204457|Sphingomonadales 204457|Sphingomonadales G Polysaccharide deacetylase - - - - - - - - - - - - Polysacc_deac_1 k59_1394347_1 436308.Nmar_0621 1.48e-49 159.0 COG1645@1|root,arCOG00578@2157|Archaea,41SVN@651137|Thaumarchaeota 651137|Thaumarchaeota S Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) - - - ko:K07143 - - - - ko00000 - - - Auto_anti-p27 k59_654640_1 1449345.JHWC01000006_gene948 1.04e-37 140.0 COG3524@1|root,COG3524@2|Bacteria,1R3ZY@1224|Proteobacteria,42MXY@68525|delta/epsilon subdivisions,2YN0A@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria M capsule polysaccharide export system inner membrane protein kpsE - - ko:K10107 ko02010,map02010 M00249 - - ko00000,ko00001,ko00002,ko02000 3.A.1.101 - - - k59_654640_2 1265502.KB905974_gene586 1.13e-09 61.2 COG1596@1|root,COG1596@2|Bacteria,1N7GP@1224|Proteobacteria,2VJBU@28216|Betaproteobacteria,4AFRQ@80864|Comamonadaceae 28216|Betaproteobacteria M Polysaccharide biosynthesis/export protein kpsD - - - - - - - - - - - Caps_synth_GfcC,Poly_export,SLBB k59_428922_1 1123279.ATUS01000006_gene3459 5.61e-15 75.1 COG3828@1|root,COG3828@2|Bacteria,1RF65@1224|Proteobacteria,1SZ1Y@1236|Gammaproteobacteria,1J9R5@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Trehalose utilisation - - - - - - - - - - - - ThuA k59_428922_2 247633.GP2143_17661 8.19e-33 127.0 COG2303@1|root,COG2303@2|Bacteria,1MU3F@1224|Proteobacteria,1RPBQ@1236|Gammaproteobacteria,1J5ZV@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E COG2303 Choline dehydrogenase and related flavoproteins neoG - - - - - - - - - - - FAD_binding_2,GMC_oxred_C,GMC_oxred_N,NAD_binding_8 k59_766856_1 1122137.AQXF01000006_gene817 3.3e-134 410.0 COG1629@1|root,COG4771@2|Bacteria,1MUWN@1224|Proteobacteria,2TUIR@28211|Alphaproteobacteria 28211|Alphaproteobacteria P COG1629 Outer membrane receptor proteins, mostly Fe transport - - - - - - - - - - - - CarbopepD_reg_2,CarboxypepD_reg,Plug,TonB_dep_Rec k59_825742_1 314265.R2601_06928 1.33e-89 278.0 COG4584@1|root,COG4584@2|Bacteria,1MWIV@1224|Proteobacteria,2TQKF@28211|Alphaproteobacteria 28211|Alphaproteobacteria L COG4584 Transposase and inactivated derivatives MA20_10900 - - - - - - - - - - - rve k59_886171_1 425104.Ssed_4375 1.27e-73 248.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,2Q984@267890|Shewanellaceae 1236|Gammaproteobacteria V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K03296 - - - - ko00000 2.A.6.2 - - ACR_tran k59_766861_1 158500.BV97_01712 1.55e-14 72.8 COG3391@1|root,COG3391@2|Bacteria,1R53R@1224|Proteobacteria,2U1FC@28211|Alphaproteobacteria,2K0VC@204457|Sphingomonadales 204457|Sphingomonadales S amine dehydrogenase activity - - - - - - - - - - - - - k59_766861_2 158500.BV97_03550 1.26e-87 259.0 COG2030@1|root,COG2030@2|Bacteria,1MW4N@1224|Proteobacteria,2TQQ2@28211|Alphaproteobacteria,2K42I@204457|Sphingomonadales 204457|Sphingomonadales I dehydratase - - - - - - - - - - - - MaoC_dehydratas k59_1106719_1 987059.RBXJA2T_02135 4.97e-07 48.5 COG0185@1|root,COG0185@2|Bacteria,1RGYX@1224|Proteobacteria,2VSGE@28216|Betaproteobacteria,1KM4Y@119065|unclassified Burkholderiales 28216|Betaproteobacteria J Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA rpsS - - ko:K02965 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S19 k59_1106719_2 497321.C664_09150 2.58e-55 174.0 COG0091@1|root,COG0091@2|Bacteria,1RH0W@1224|Proteobacteria,2VSE6@28216|Betaproteobacteria,2KWKB@206389|Rhodocyclales 206389|Rhodocyclales J The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome rplV - - ko:K02890 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L22 k59_1106719_3 511.JT27_05825 4.59e-67 210.0 COG0092@1|root,COG0092@2|Bacteria,1MUAI@1224|Proteobacteria,2VHQN@28216|Betaproteobacteria,3T1UN@506|Alcaligenaceae 28216|Betaproteobacteria J Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation rpsC - - ko:K02982 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - KH_2,Ribosomal_S3_C k59_1782295_1 34007.IT40_00730 5.84e-44 147.0 COG0789@1|root,COG0789@2|Bacteria,1RGX6@1224|Proteobacteria,2U98F@28211|Alphaproteobacteria,2PXB9@265|Paracoccus 28211|Alphaproteobacteria K helix_turn_helix, mercury resistance - - - ko:K19591 - M00769 - - ko00000,ko00002,ko01504,ko03000 - - - MerR,MerR-DNA-bind,MerR_1 k59_205539_1 1121479.AUBS01000007_gene2275 0.000878 42.7 COG0213@1|root,COG0213@2|Bacteria,1MV3H@1224|Proteobacteria,2TS24@28211|Alphaproteobacteria 28211|Alphaproteobacteria F The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis deoA - 2.4.2.4 ko:K00758 ko00240,ko00983,ko01100,ko05219,map00240,map00983,map01100,map05219 - R01570,R02484,R08222,R08230 RC00063 ko00000,ko00001,ko01000 - - - Glycos_trans_3N,Glycos_transf_3,PYNP_C k59_205539_2 555793.WSK_2513 7.69e-20 90.1 COG1972@1|root,COG1972@2|Bacteria,1MXXX@1224|Proteobacteria,2TU8A@28211|Alphaproteobacteria,2K07T@204457|Sphingomonadales 204457|Sphingomonadales F nucleoside - - - ko:K03317 - - - - ko00000 2.A.41 - - Gate,Nucleos_tra2_C,Nucleos_tra2_N k59_377665_1 1056820.KB900700_gene1157 7.85e-39 139.0 COG1560@1|root,COG1560@2|Bacteria,1Q41N@1224|Proteobacteria,1RRRE@1236|Gammaproteobacteria,2PNHD@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria M Bacterial lipid A biosynthesis acyltransferase htrB - 2.3.1.241 ko:K02517 ko00540,ko01100,map00540,map01100 M00060 R05146 RC00037,RC00039 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Lip_A_acyltrans k59_377665_2 1278309.KB907105_gene1462 1.72e-20 88.6 28NM7@1|root,2ZBMT@2|Bacteria,1R9Y9@1224|Proteobacteria,1S227@1236|Gammaproteobacteria,1XJBR@135619|Oceanospirillales 135619|Oceanospirillales S Protein of unknown function (DUF2959) - - - - - - - - - - - - DUF2959 k59_1617730_1 342610.Patl_2492 6.44e-33 131.0 COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,1RPM5@1236|Gammaproteobacteria,2PZH6@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria I COG1960 Acyl-CoA dehydrogenases fadE GO:0003674,GO:0003824,GO:0003995,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009987,GO:0016020,GO:0016042,GO:0016054,GO:0016491,GO:0016627,GO:0019395,GO:0019752,GO:0030258,GO:0032787,GO:0033539,GO:0034440,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044464,GO:0046395,GO:0055114,GO:0071704,GO:0071944,GO:0072329,GO:1901575 - ko:K06445 ko00071,ko01100,ko01212,map00071,map01100,map01212 M00087 R01175,R01279,R03777,R03857,R03990,R04751,R04754 RC00052,RC00076 ko00000,ko00001,ko00002,ko01000 - - iSbBS512_1146.SbBS512_E0217 Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N,DUF1974 k59_937054_1 911045.PSE_1007 3.14e-25 95.9 COG0291@1|root,COG0291@2|Bacteria,1N6V4@1224|Proteobacteria,2UF6K@28211|Alphaproteobacteria 28211|Alphaproteobacteria J Belongs to the bacterial ribosomal protein bL35 family rpmI GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - ko:K02916 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L35p k59_937054_2 1122137.AQXF01000004_gene1407 1.96e-66 203.0 COG0292@1|root,COG0292@2|Bacteria,1RGU2@1224|Proteobacteria,2U756@28211|Alphaproteobacteria 28211|Alphaproteobacteria J Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit rplT GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0006996,GO:0008150,GO:0009987,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0042254,GO:0042255,GO:0042273,GO:0043933,GO:0044085,GO:0065003,GO:0070925,GO:0071826,GO:0071840 - ko:K02887 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L20 k59_937054_3 1122929.KB908216_gene1920 2.16e-21 93.2 COG0016@1|root,COG0016@2|Bacteria,1MVD7@1224|Proteobacteria,2TS2T@28211|Alphaproteobacteria 28211|Alphaproteobacteria J Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily pheS GO:0003674,GO:0003824,GO:0004812,GO:0004826,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.20 ko:K01889 ko00970,map00970 M00359,M00360 R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Phe_tRNA-synt_N,tRNA-synt_2d k59_262806_1 1122194.AUHU01000011_gene1704 1.4e-84 276.0 COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,1SP6I@1236|Gammaproteobacteria,464J4@72275|Alteromonadaceae 1236|Gammaproteobacteria P Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family cusA - - ko:K07787 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.6.1.4 - - ACR_tran k59_1445312_1 314260.PB2503_12529 1.23e-20 87.4 COG5014@1|root,COG5014@2|Bacteria,1NW72@1224|Proteobacteria,2USAJ@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_1730295_1 983920.Y88_0863 2.11e-44 154.0 COG3876@1|root,COG3876@2|Bacteria,1MX3S@1224|Proteobacteria,2U1KM@28211|Alphaproteobacteria,2K0PB@204457|Sphingomonadales 204457|Sphingomonadales S Protein of unknown function (DUF1343) - - - - - - - - - - - - DUF1343 k59_484530_1 391603.FBALC1_01377 1.15e-112 346.0 COG4717@1|root,COG4717@2|Bacteria,4PKS5@976|Bacteroidetes,1IJEB@117743|Flavobacteriia 976|Bacteroidetes S Peptidase S46 dpp11 GO:0003674,GO:0003824,GO:0004177,GO:0006508,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0008239,GO:0009056,GO:0009987,GO:0016787,GO:0019538,GO:0034641,GO:0043170,GO:0043171,GO:0043603,GO:0044237,GO:0044238,GO:0044248,GO:0070011,GO:0071704,GO:0140096,GO:1901564,GO:1901565,GO:1901575 - - - - - - - - - - Peptidase_S46 k59_825768_1 365528.KB891267_gene5936 3.15e-54 190.0 COG0318@1|root,COG0318@2|Bacteria,2IEKP@201174|Actinobacteria 201174|Actinobacteria IQ AMP-binding enzyme C-terminal domain - - - - - - - - - - - - AMP-binding,AMP-binding_C k59_1332238_1 1121937.AUHJ01000004_gene1139 2.68e-77 241.0 COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,1RNXA@1236|Gammaproteobacteria,465VR@72275|Alteromonadaceae 1236|Gammaproteobacteria E COG0436 Aspartate tyrosine aromatic aminotransferase - - 4.1.1.82 ko:K09459,ko:K10907 ko00440,ko01100,ko01120,ko01130,map00440,map01100,map01120,map01130 - R04053 RC00506 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_1_2 k59_1332238_2 1323663.AROI01000003_gene2231 7.63e-10 58.9 COG0154@1|root,COG0154@2|Bacteria,1MW3Z@1224|Proteobacteria,1RP33@1236|Gammaproteobacteria 1236|Gammaproteobacteria J COG0154 Asp-tRNAAsn Glu-tRNAGln amidotransferase A subunit and related amidases - - 6.3.5.6,6.3.5.7 ko:K02433 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - Amidase k59_602892_1 1125863.JAFN01000001_gene41 5.24e-26 98.6 COG0333@1|root,COG0333@2|Bacteria,1NGM1@1224|Proteobacteria,42XHF@68525|delta/epsilon subdivisions,2WSX6@28221|Deltaproteobacteria 28221|Deltaproteobacteria J Belongs to the bacterial ribosomal protein bL32 family rpmF GO:0003674,GO:0003735,GO:0005198 - ko:K02911 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011,ko03029 - - - Ribosomal_L32p k59_602892_2 1161902.HMPREF0378_0631 2.71e-12 67.0 COG0416@1|root,COG0416@2|Bacteria,1TPXS@1239|Firmicutes,247KW@186801|Clostridia,3WCHB@538999|Clostridiales incertae sedis 186801|Clostridia I Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA plsX - 2.3.1.15 ko:K03621 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R00851,R09380 RC00004,RC00039,RC00041 ko00000,ko00001,ko00002,ko01000,ko01004 - - - FA_synthesis k59_937070_1 1128421.JAGA01000001_gene2399 3.04e-59 197.0 COG0179@1|root,COG0179@2|Bacteria 2|Bacteria Q Fumarylacetoacetate (FAA) hydrolase fahA - 3.7.1.2 ko:K01555 ko00350,ko00643,ko01100,ko01120,map00350,map00643,map01100,map01120 M00044 R01364 RC00326,RC00446 ko00000,ko00001,ko00002,ko01000,ko04147 - - iJN746.PP_4620 FAA_hydrolase,FAA_hydrolase_N k59_715872_2 1111069.TCCBUS3UF1_15600 8.21e-16 80.5 COG0607@1|root,COG0607@2|Bacteria,1WJ03@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus P Rhodanese Homology Domain - - - - - - - - - - - - Rhodanese k59_715872_3 1247963.JPHU01000011_gene794 2.29e-15 74.7 COG0491@1|root,COG0491@2|Bacteria,1MURA@1224|Proteobacteria,2TR1F@28211|Alphaproteobacteria 28211|Alphaproteobacteria P COG0491 Zn-dependent hydrolases, including glyoxylases - - - - - - - - - - - - Lactamase_B k59_766904_1 85643.Tmz1t_3956 6.58e-37 138.0 COG0322@1|root,COG0847@1|root,COG0322@2|Bacteria,COG0847@2|Bacteria,1MV8Z@1224|Proteobacteria,2VK3W@28216|Betaproteobacteria,2KUJD@206389|Rhodocyclales 206389|Rhodocyclales L DNA polymerase III, epsilon subunit - - 2.7.7.7 ko:K02342 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - GIY-YIG,RNase_T k59_1507421_2 247633.GP2143_17461 6.01e-79 251.0 COG1409@1|root,COG1409@2|Bacteria 2|Bacteria S acid phosphatase activity - - - - - - - - - - - - Metallophos,Pur_ac_phosph_N k59_1222228_1 1121272.KB903249_gene2377 5.38e-28 112.0 COG1317@1|root,COG1317@2|Bacteria,2H94N@201174|Actinobacteria,4DCZ2@85008|Micromonosporales 201174|Actinobacteria NU bacterial-type flagellum organization - - - - - - - - - - - - - k59_93898_1 395495.Lcho_0338 7.21e-25 98.2 COG4094@1|root,COG4094@2|Bacteria,1RDHB@1224|Proteobacteria,2VQBI@28216|Betaproteobacteria,1KKYD@119065|unclassified Burkholderiales 28216|Betaproteobacteria S NnrU protein nnrU - - - - - - - - - - - NnrU k59_539505_1 1122137.AQXF01000003_gene2182 5.75e-109 327.0 COG0161@1|root,COG0161@2|Bacteria,1MU2N@1224|Proteobacteria,2TQND@28211|Alphaproteobacteria 2|Bacteria E Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family - - - - - - - - - - - - Aminotran_3 k59_1106753_2 309801.trd_A0429 9e-103 306.0 COG1028@1|root,COG1028@2|Bacteria,2G6IK@200795|Chloroflexi,27Y50@189775|Thermomicrobia 189775|Thermomicrobia IQ Dehydrogenase - - - - - - - - - - - - adh_short_C2 k59_1672223_2 1230476.C207_07058 2.6e-26 102.0 COG0346@1|root,COG0346@2|Bacteria,1N7R0@1224|Proteobacteria,2U65K@28211|Alphaproteobacteria,3JY8W@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria E Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - - - - - - - - - - Glyoxalase k59_1222233_1 391603.FBALC1_16447 3.33e-56 200.0 COG3291@1|root,COG3291@2|Bacteria 2|Bacteria S metallopeptidase activity - - - - - - - - - - - - CHU_C,CUB,Cleaved_Adhesin,PKD,fn3 k59_205596_2 1216007.AOPM01000038_gene2693 3.57e-08 54.3 COG1726@1|root,COG1726@2|Bacteria,1MU36@1224|Proteobacteria,1RPU1@1236|Gammaproteobacteria,2Q169@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol nqrA GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0006810,GO:0006811,GO:0006812,GO:0006814,GO:0008137,GO:0008150,GO:0008152,GO:0015672,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0030001,GO:0030964,GO:0032991,GO:0044425,GO:0050136,GO:0051179,GO:0051234,GO:0055114,GO:0098796,GO:1902494 1.6.5.8 ko:K00346 - - - - ko00000,ko01000 - - - NQRA,NQRA_SLBB k59_435390_2 555079.Toce_0122 1.04e-124 362.0 COG0090@1|root,COG0090@2|Bacteria,1TP9X@1239|Firmicutes,247XY@186801|Clostridia,42EWJ@68295|Thermoanaerobacterales 186801|Clostridia J One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity rplB - - ko:K02886 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L2,Ribosomal_L2_C k59_1678777_1 1282876.BAOK01000001_gene1964 1.18e-55 192.0 COG0651@1|root,COG0651@2|Bacteria,1MV6V@1224|Proteobacteria,2TSJC@28211|Alphaproteobacteria,4BRKG@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria CP Proton-conducting membrane transporter nuoL3 - - ko:K05568 - - - - ko00000,ko02000 2.A.63.1,2.A.63.2 - - Proton_antipo_M k59_1228329_1 1236959.BAMT01000014_gene2917 3.8e-70 221.0 COG0468@1|root,COG0468@2|Bacteria,1MU3C@1224|Proteobacteria,2VHNA@28216|Betaproteobacteria,2KKYB@206350|Nitrosomonadales 206350|Nitrosomonadales L Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage recA - - ko:K03553 ko03440,map03440 M00729 - - ko00000,ko00001,ko00002,ko03400 - - - RecA k59_1228329_2 1040989.AWZU01000028_gene2940 1.05e-17 80.9 COG2084@1|root,COG2084@2|Bacteria,1MUGU@1224|Proteobacteria,2TT50@28211|Alphaproteobacteria,3JS5I@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria I NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase MA20_25935 - 1.1.1.31,1.1.1.60 ko:K00020,ko:K00042 ko00280,ko00630,ko01100,map00280,map00630,map01100 - R01745,R01747,R05066 RC00099 ko00000,ko00001,ko01000 - - - NAD_binding_11,NAD_binding_2 k59_1338608_1 314270.RB2083_374 4.05e-38 132.0 COG0346@1|root,COG0346@2|Bacteria,1N1D4@1224|Proteobacteria,2UGZ0@28211|Alphaproteobacteria 28211|Alphaproteobacteria E COG0346 Lactoylglutathione lyase and related lyases - - - - - - - - - - - - Glyoxalase k59_1338608_2 402881.Plav_3097 1.15e-163 469.0 COG1902@1|root,COG1902@2|Bacteria,1MVIX@1224|Proteobacteria,2TT2F@28211|Alphaproteobacteria,1JNG6@119043|Rhodobiaceae 28211|Alphaproteobacteria C NADH:flavin oxidoreductase / NADH oxidase family - - 1.14.13.40 ko:K09461 ko00627,ko01120,map00627,map01120 - R03998,R03999 RC00244 ko00000,ko00001,ko01000 - - - Oxidored_FMN k59_1338610_1 1056820.KB900699_gene1212 1.04e-87 270.0 COG0148@1|root,COG0148@2|Bacteria,1MU1N@1224|Proteobacteria,1RNQA@1236|Gammaproteobacteria,2PMIN@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria G Enolase, N-terminal domain eno GO:0000015,GO:0000287,GO:0003674,GO:0003824,GO:0004634,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005856,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009986,GO:0009987,GO:0016052,GO:0016053,GO:0016310,GO:0016829,GO:0016835,GO:0016836,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0032991,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042802,GO:0042866,GO:0043167,GO:0043169,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046872,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1902494 4.2.1.11 ko:K01689 ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066 M00001,M00002,M00003,M00346,M00394 R00658 RC00349 ko00000,ko00001,ko00002,ko01000,ko03019,ko04147 - - iPC815.YPO3376 Enolase_C,Enolase_N k59_211797_2 555793.WSK_3870 2.51e-104 318.0 COG0323@1|root,COG0323@2|Bacteria,1MV61@1224|Proteobacteria,2TR2M@28211|Alphaproteobacteria,2K2AP@204457|Sphingomonadales 204457|Sphingomonadales L This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex mutL - - ko:K03572 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - DNA_mis_repair,HATPase_c_3,MutL_C k59_773420_1 471852.Tcur_1559 0.000515 43.9 COG2267@1|root,COG2267@2|Bacteria,2IB21@201174|Actinobacteria 201174|Actinobacteria I Serine aminopeptidase, S33 - - - - - - - - - - - - Abhydrolase_1 k59_773420_2 644282.Deba_1869 2.92e-27 108.0 COG0558@1|root,COG0558@2|Bacteria,1RCZ7@1224|Proteobacteria,42QQ4@68525|delta/epsilon subdivisions,2WQGH@28221|Deltaproteobacteria 28221|Deltaproteobacteria I Belongs to the CDP-alcohol phosphatidyltransferase class-I family pgsA - 2.7.8.5 ko:K00995 ko00564,ko01100,map00564,map01100 - R01801 RC00002,RC00017,RC02795 ko00000,ko00001,ko01000 - - - CDP-OH_P_transf k59_773421_1 685778.AORL01000009_gene3235 3.27e-58 191.0 COG0598@1|root,COG0598@2|Bacteria,1MWMP@1224|Proteobacteria,2TQQD@28211|Alphaproteobacteria,2K4ZK@204457|Sphingomonadales 204457|Sphingomonadales P CorA-like Mg2+ transporter protein - - - ko:K03284 - - - - ko00000,ko02000 1.A.35.1,1.A.35.3 - - CorA k59_1678789_1 642492.Clole_3607 2.35e-24 102.0 COG1077@1|root,COG1077@2|Bacteria,1TP51@1239|Firmicutes,247RG@186801|Clostridia 186801|Clostridia D Cell shape determining protein, MreB Mrl family mreB - - ko:K03569 - - - - ko00000,ko02048,ko03036,ko04812 1.A.33.1,9.B.157.1 - - MreB_Mbl k59_999506_1 384765.SIAM614_29501 1.87e-43 150.0 COG1740@1|root,COG1740@2|Bacteria,1MWAC@1224|Proteobacteria,2TUYA@28211|Alphaproteobacteria 28211|Alphaproteobacteria C NADH ubiquinone oxidoreductase 20 kDa subunit hupU - 1.12.7.2 ko:K00534 - - R00019 - ko00000,ko01000 - - - NiFe_hyd_SSU_C,Oxidored_q6 k59_270412_1 522373.Smlt3755 1.53e-99 306.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,1X3DA@135614|Xanthomonadales 135614|Xanthomonadales T Response regulator containing CheY-like receiver AAA-type ATPase and DNA-binding domains pilR - - ko:K02667 ko02020,map02020 M00501 - - ko00000,ko00001,ko00002,ko02022,ko02035 - - - HTH_8,Response_reg,Sigma54_activat k59_833032_1 1458357.BG58_13590 2.51e-98 310.0 COG0188@1|root,COG0188@2|Bacteria,1MUGG@1224|Proteobacteria,2VJ5Q@28216|Betaproteobacteria,1K0UC@119060|Burkholderiaceae 28216|Betaproteobacteria L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrA - 5.99.1.3 ko:K02469 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseA_C,DNA_topoisoIV k59_1789713_1 1123279.ATUS01000005_gene3240 4.74e-112 326.0 COG0529@1|root,COG0529@2|Bacteria,1MX0D@1224|Proteobacteria,1RNWT@1236|Gammaproteobacteria,1J5Y1@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria F Catalyzes the synthesis of activated sulfate cysC - 2.7.1.25,2.7.7.4 ko:K00860,ko:K00958 ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130 M00176,M00596 R00509,R00529,R04928,R04929 RC00002,RC00078,RC02809,RC02889 ko00000,ko00001,ko00002,ko01000 - - - APS_kinase,ATP-sulfurylase,PUA_2 k59_1789713_2 1255043.TVNIR_3614 1.42e-06 48.9 COG2046@1|root,COG2046@2|Bacteria,1MUQB@1224|Proteobacteria,1RP4Q@1236|Gammaproteobacteria,1WWF2@135613|Chromatiales 135613|Chromatiales P Belongs to the sulfate adenylyltransferase family sat - 2.7.7.4 ko:K00958 ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130 M00176,M00596 R00529,R04929 RC02809,RC02889 ko00000,ko00001,ko00002,ko01000 - - - ATP-sulfurylase,PUA_2 k59_1514791_2 1134474.O59_004065 6.66e-16 77.8 COG0515@1|root,COG1262@1|root,COG0515@2|Bacteria,COG1262@2|Bacteria,1MWVZ@1224|Proteobacteria,1RQBQ@1236|Gammaproteobacteria,1FGUJ@10|Cellvibrio 1236|Gammaproteobacteria KLT Protein kinase domain stk1 - 2.7.11.1 ko:K08282,ko:K11916,ko:K12132 - - - - ko00000,ko01000,ko01001,ko02044 - - - FGE-sulfatase,Pkinase k59_1624804_1 100226.SCO6438 1.35e-106 322.0 COG0019@1|root,COG0019@2|Bacteria,2HHG9@201174|Actinobacteria 201174|Actinobacteria E Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine - - 4.1.1.20 ko:K01586 ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R00451 RC00299 ko00000,ko00001,ko00002,ko01000 - - - Orn_Arg_deC_N,Orn_DAP_Arg_deC k59_1514793_1 1249627.D779_0248 6.71e-93 287.0 COG0366@1|root,COG0366@2|Bacteria,1MVKX@1224|Proteobacteria,1RMXP@1236|Gammaproteobacteria,1WXXQ@135613|Chromatiales 135613|Chromatiales G Alpha amylase catalytic - - 2.4.1.7 ko:K00690 ko00500,map00500 - R00803 RC00028 ko00000,ko00001,ko01000 - GH13 - - k59_1402252_1 1294143.H681_05615 1.42e-64 209.0 COG0472@1|root,COG0472@2|Bacteria,1MUTK@1224|Proteobacteria,1RNIG@1236|Gammaproteobacteria 1236|Gammaproteobacteria M First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan mraY GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008963,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016780,GO:0030203,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 2.7.8.13 ko:K01000 ko00550,ko01100,ko01502,map00550,map01100,map01502 - R05629,R05630 RC00002,RC02753 ko00000,ko00001,ko01000,ko01011 9.B.146 - iEC042_1314.EC042_0088,iECABU_c1320.ECABU_c00920,iECED1_1282.ECED1_0088,iECH74115_1262.ECH74115_0095,iECSP_1301.ECSP_0090,iECs_1301.ECs0091,iG2583_1286.G2583_0091,iSDY_1059.SDY_0117,iZ_1308.Z0097,ic_1306.c0105 Glycos_transf_4,MraY_sig1 k59_1061600_1 1121012.AUKX01000004_gene3501 1.55e-52 167.0 2DNS7@1|root,32YWC@2|Bacteria,4NSJ6@976|Bacteroidetes,1IK8G@117743|Flavobacteriia,23IGT@178469|Arenibacter 976|Bacteroidetes S 23S rRNA-intervening sequence protein - - - - - - - - - - - - 23S_rRNA_IVP k59_723566_1 1123288.SOV_4c07050 2.76e-73 236.0 COG4992@1|root,COG4992@2|Bacteria,1TP9S@1239|Firmicutes,4H2ZB@909932|Negativicutes 909932|Negativicutes E Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family - - 2.6.1.82 ko:K09251 ko00330,ko01100,map00330,map01100 - R01155 RC00006,RC00062 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_3 k59_155508_1 158500.BV97_02415 1.48e-69 210.0 COG0347@1|root,COG0347@2|Bacteria,1RGWK@1224|Proteobacteria,2U73Z@28211|Alphaproteobacteria,2K4IQ@204457|Sphingomonadales 204457|Sphingomonadales K Belongs to the P(II) protein family glnB - - ko:K04751 ko02020,map02020 - - - ko00000,ko00001 - - - P-II k59_155508_2 1144305.PMI02_03645 5.73e-07 50.1 COG0002@1|root,COG0002@2|Bacteria,1MVJ6@1224|Proteobacteria,2TRMT@28211|Alphaproteobacteria,2K2G3@204457|Sphingomonadales 204457|Sphingomonadales E Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde argC - 1.2.1.38 ko:K00145 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028,M00845 R03443 RC00684 ko00000,ko00001,ko00002,ko01000 - - - Semialdhyde_dh k59_1061606_1 525368.HMPREF0591_5471 5.24e-19 91.7 COG2114@1|root,COG3899@1|root,COG2114@2|Bacteria,COG3899@2|Bacteria,2GJRI@201174|Actinobacteria,2364D@1762|Mycobacteriaceae 201174|Actinobacteria T PFAM Adenylate and Guanylate cyclase catalytic domain - - - - - - - - - - - - AAA_16,Guanylate_cyc,zinc_ribbon_2 k59_547432_2 702113.PP1Y_Mpl626 0.0 926.0 COG4773@1|root,COG4773@2|Bacteria,1QWUE@1224|Proteobacteria,2UP1W@28211|Alphaproteobacteria,2K3PE@204457|Sphingomonadales 204457|Sphingomonadales P TonB-dependent Receptor Plug Domain - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_1229058_1 589865.DaAHT2_1929 1.76e-71 218.0 COG0377@1|root,COG0377@2|Bacteria,1MUI2@1224|Proteobacteria,42MDJ@68525|delta/epsilon subdivisions,2WNNV@28221|Deltaproteobacteria,2MNCS@213118|Desulfobacterales 28221|Deltaproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoB - 1.6.5.3 ko:K00331 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q6 k59_1229058_2 1167006.UWK_03559 3.63e-28 105.0 COG0838@1|root,COG0838@2|Bacteria,1PPP3@1224|Proteobacteria,42VF4@68525|delta/epsilon subdivisions,2WRIV@28221|Deltaproteobacteria,2MMCP@213118|Desulfobacterales 28221|Deltaproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain nuoA - 1.6.5.3 ko:K00330 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q4 k59_1453033_3 1510531.JQJJ01000012_gene1478 4.5e-50 161.0 COG0105@1|root,COG0105@2|Bacteria,1R9ZA@1224|Proteobacteria,2U5CS@28211|Alphaproteobacteria,3JY2D@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria F Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate ndk GO:0003674,GO:0003824,GO:0004550,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006165,GO:0006220,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009132,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0019205,GO:0019637,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0044464,GO:0046483,GO:0046939,GO:0055086,GO:0071704,GO:0072521,GO:0072527,GO:1901360,GO:1901564 2.7.4.6 ko:K00940 ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016 M00049,M00050,M00052,M00053 R00124,R00139,R00156,R00330,R00570,R00722,R01137,R01857,R02093,R02326,R02331,R03530,R11894,R11895 RC00002 ko00000,ko00001,ko00002,ko01000,ko04131 - - - NDK k59_833067_1 265072.Mfla_1031 8.5e-56 197.0 COG0046@1|root,COG0047@1|root,COG0046@2|Bacteria,COG0047@2|Bacteria,1MYN4@1224|Proteobacteria,2VHTE@28216|Betaproteobacteria,2KKQX@206350|Nitrosomonadales 206350|Nitrosomonadales F Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate purL - 6.3.5.3 ko:K01952 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04463 RC00010,RC01160 ko00000,ko00001,ko00002,ko01000 - - - AIRS_C,GATase_5 k59_270429_1 1415778.JQMM01000001_gene437 8.69e-39 144.0 COG0654@1|root,COG0654@2|Bacteria,1MU6I@1224|Proteobacteria,1RMS3@1236|Gammaproteobacteria,1J5VF@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria CH COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases ubiH GO:0003674,GO:0003824,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008681,GO:0009058,GO:0009108,GO:0009314,GO:0009416,GO:0009628,GO:0009987,GO:0016491,GO:0016705,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0050896,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:1901576,GO:1901661,GO:1901663 - ko:K03185,ko:K18800 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00117 R04987,R04989,R08768,R08773 RC00046,RC02670 ko00000,ko00001,ko00002,ko01000 - - iB21_1397.B21_02702,iECBD_1354.ECBD_0830,iECB_1328.ECB_02739,iECD_1391.ECD_02739,iEcHS_1320.EcHS_A3066 FAD_binding_3 k59_1402273_1 155864.EDL933_5011 9.1e-106 320.0 COG0569@1|root,COG2985@1|root,COG0569@2|Bacteria,COG2985@2|Bacteria,1MUVM@1224|Proteobacteria,1RQY2@1236|Gammaproteobacteria,3XNHV@561|Escherichia 1236|Gammaproteobacteria P potassium ion transport yidE GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K07085 - - - - ko00000 2.A.81 - - Asp-Al_Ex,TrkA_C k59_270440_1 199310.c0003 1.76e-110 340.0 COG0460@1|root,COG0527@1|root,COG0460@2|Bacteria,COG0527@2|Bacteria,1MW3H@1224|Proteobacteria,1RN1G@1236|Gammaproteobacteria,3XN2A@561|Escherichia 1236|Gammaproteobacteria E homoserine dehydrogenase I thrA GO:0003674,GO:0003824,GO:0004072,GO:0004412,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006553,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009070,GO:0009085,GO:0009089,GO:0009090,GO:0009092,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016491,GO:0016614,GO:0016616,GO:0016740,GO:0016772,GO:0016774,GO:0019202,GO:0019752,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046451,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.3,2.7.2.4 ko:K12524,ko:K12525 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00017,M00018,M00526,M00527 R00480,R01773,R01775 RC00002,RC00043,RC00087 ko00000,ko00001,ko00002,ko01000 - - iECDH1ME8569_1439.ECDH1ME8569_0002,iEcDH1_1363.EcDH1_3594,iSFV_1184.SFV_0001,iUMNK88_1353.UMNK88_4778 AA_kinase,ACT,ACT_7,Homoserine_dh,NAD_binding_3 k59_1114293_1 1163617.SCD_n01575 2.86e-27 112.0 COG3127@1|root,COG3127@2|Bacteria,1MU9R@1224|Proteobacteria,2VHHQ@28216|Betaproteobacteria 28216|Betaproteobacteria Q ABC-type transport system involved in lysophospholipase L1 biosynthesis permease component - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_1114293_2 323850.Shew_2402 7.95e-45 153.0 COG4181@1|root,COG4181@2|Bacteria,1MXG9@1224|Proteobacteria,1RMG1@1236|Gammaproteobacteria,2Q9M2@267890|Shewanellaceae 1236|Gammaproteobacteria Q PFAM ABC transporter related ybbA GO:0000166,GO:0003674,GO:0005488,GO:0005524,GO:0008144,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_1000331_1 742743.HMPREF9453_00756 4.29e-14 72.8 COG0497@1|root,COG0497@2|Bacteria,1TP99@1239|Firmicutes,4H30U@909932|Negativicutes 909932|Negativicutes L May be involved in recombinational repair of damaged DNA recN - - ko:K03631 - - - - ko00000,ko03400 - - - AAA_23,SMC_N k59_1000331_2 1379698.RBG1_1C00001G1130 1.08e-47 167.0 COG0061@1|root,COG0061@2|Bacteria,2NP7T@2323|unclassified Bacteria 2|Bacteria G Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP nadK GO:0000166,GO:0003674,GO:0003824,GO:0003951,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006741,GO:0006753,GO:0006766,GO:0006767,GO:0006769,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008976,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009820,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016776,GO:0017076,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046496,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0051287,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:0097367,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 2.7.1.23 ko:K00858 ko00760,ko01100,map00760,map01100 - R00104 RC00002,RC00078 ko00000,ko00001,ko01000 - - iEcSMS35_1347.EcSMS35_2767,iHN637.CLJU_RS05480,iLJ478.TM1733,iSB619.SA_RS04895 NAD_kinase k59_1679908_1 1328313.DS2_10913 5.6e-51 165.0 COG2606@1|root,COG2606@2|Bacteria,1RGX5@1224|Proteobacteria,1S6S0@1236|Gammaproteobacteria,466UK@72275|Alteromonadaceae 1236|Gammaproteobacteria S Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily ybaK GO:0002161,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006399,GO:0006450,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009314,GO:0009628,GO:0009987,GO:0010165,GO:0010212,GO:0016070,GO:0016787,GO:0016788,GO:0034641,GO:0034660,GO:0043170,GO:0043906,GO:0043907,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360 - ko:K03976 - - - - ko00000,ko01000,ko03016 - - - tRNA_edit k59_1679908_2 768066.HELO_2032 9.75e-26 98.2 COG0346@1|root,COG0346@2|Bacteria,1N116@1224|Proteobacteria,1S4X5@1236|Gammaproteobacteria,1XPB8@135619|Oceanospirillales 135619|Oceanospirillales E Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - ko:K07032 - - - - ko00000 - - - Glyoxalase k59_893685_2 1122137.AQXF01000001_gene2699 4.44e-64 206.0 COG2267@1|root,COG2267@2|Bacteria,1MWDA@1224|Proteobacteria,2TSZ4@28211|Alphaproteobacteria 28211|Alphaproteobacteria I alpha, beta pldB - 3.1.1.5 ko:K01048 ko00564,map00564 - - - ko00000,ko00001,ko01000 - - - Hydrolase_4 k59_212585_1 1122137.AQXF01000001_gene2924 7.61e-86 276.0 COG3127@1|root,COG3127@2|Bacteria,1MU9R@1224|Proteobacteria,2TS8V@28211|Alphaproteobacteria 28211|Alphaproteobacteria Q ABC-type transport system involved in lysophospholipase L1 biosynthesis permease component MA20_43810 - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_1453069_1 316407.4062773 4.62e-202 568.0 COG2719@1|root,COG2719@2|Bacteria,1MW6U@1224|Proteobacteria,1RPU2@1236|Gammaproteobacteria,3XMG4@561|Escherichia 1236|Gammaproteobacteria S cellular response to DNA damage stimulus ycgB GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0033554,GO:0050896,GO:0051716 - ko:K06415 - - - - ko00000 - - - SpoVR k59_1789766_1 446466.Cfla_1584 1.01e-11 71.2 COG1305@1|root,COG1305@2|Bacteria,2HQBB@201174|Actinobacteria,4F0VJ@85016|Cellulomonadaceae 201174|Actinobacteria E Transglutaminase/protease-like homologues - - - - - - - - - - - - DUF4129,Transglut_core k59_155569_1 706587.Desti_2009 3.03e-37 147.0 COG1529@1|root,COG1529@2|Bacteria,1QTTJ@1224|Proteobacteria,42NU9@68525|delta/epsilon subdivisions,2WKXG@28221|Deltaproteobacteria,2MRDM@213462|Syntrophobacterales 28221|Deltaproteobacteria C Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL CutL-like protein - - 1.3.99.16 ko:K07303 - - - - ko00000,ko01000 - - - Ald_Xan_dh_C2 k59_1000342_2 1163409.UUA_16593 1.67e-62 204.0 COG2896@1|root,COG2896@2|Bacteria,1MW3W@1224|Proteobacteria,1RR68@1236|Gammaproteobacteria,1X46A@135614|Xanthomonadales 135614|Xanthomonadales H Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate moaA - 4.1.99.22 ko:K03639 ko00790,ko01100,ko04122,map00790,map01100,map04122 - R09394 RC03420 ko00000,ko00001,ko01000 - - - Fer4_12,Mob_synth_C,Radical_SAM k59_1061649_1 113395.AXAI01000002_gene5515 1.25e-32 126.0 COG2159@1|root,COG2159@2|Bacteria,1R5PG@1224|Proteobacteria,2U2G9@28211|Alphaproteobacteria,3JWBY@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S Amidohydrolase - - - - - - - - - - - - Amidohydro_2 k59_1061649_2 1121396.KB893058_gene2565 5.88e-10 60.1 COG0657@1|root,COG0657@2|Bacteria 2|Bacteria I acetylesterase activity - - 3.1.1.3 ko:K01046 ko00561,ko01100,map00561,map01100 M00098 R02250,R02687 RC00020,RC00037,RC00041,RC00094 ko00000,ko00001,ko00002,ko01000 - - - Abhydrolase_3,Peptidase_S9 k59_547488_1 1472716.KBK24_0120265 1.81e-118 362.0 COG2433@1|root,COG2433@2|Bacteria,1RJ1Q@1224|Proteobacteria,2VKSJ@28216|Betaproteobacteria,1KG5R@119060|Burkholderiaceae 28216|Betaproteobacteria S transposase IS66 - - - ko:K07484 - - - - ko00000 - - - DDE_Tnp_IS66,DDE_Tnp_IS66_C,LZ_Tnp_IS66,zf-IS66 k59_662642_1 501479.ACNW01000062_gene2740 1.07e-19 88.6 28HMZ@1|root,2Z7WD@2|Bacteria,1MU3Q@1224|Proteobacteria,2TSGX@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Protein of unknown function (DUF3604) - - - - - - - - - - - - DUF3604 k59_662642_2 42565.FP66_00700 1.52e-43 144.0 COG3126@1|root,COG3126@2|Bacteria,1N8AF@1224|Proteobacteria,1SCM7@1236|Gammaproteobacteria 1236|Gammaproteobacteria S protein conserved in bacteria ybaY - - ko:K09914 - - - - ko00000 - - - YscW k59_723641_1 1123503.KB908056_gene1352 1.41e-20 92.0 COG0772@1|root,COG0772@2|Bacteria,1MUK3@1224|Proteobacteria,2TSM0@28211|Alphaproteobacteria,2KFNQ@204458|Caulobacterales 204458|Caulobacterales M Peptidoglycan polymerase that is essential for cell wall elongation mrdB - - ko:K05837 - - - - ko00000,ko03036 - - - FTSW_RODA_SPOVE k59_723641_2 1569209.BBPH01000013_gene3753 9.01e-59 203.0 COG0768@1|root,COG0768@2|Bacteria,1MV8C@1224|Proteobacteria,2TRXN@28211|Alphaproteobacteria,2PVQM@265|Paracoccus 28211|Alphaproteobacteria M Penicillin-binding Protein dimerisation domain mrdA - 3.4.16.4 ko:K05515 ko00550,ko01501,map00550,map01501 - - - ko00000,ko00001,ko01000,ko01011 - - - PBP_dimer,Transpeptidase k59_944623_1 497321.C664_09813 4.09e-23 96.3 COG2010@1|root,COG2010@2|Bacteria,1MUCW@1224|Proteobacteria,2VHGS@28216|Betaproteobacteria,2KUZH@206389|Rhodocyclales 206389|Rhodocyclales C C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex ccoP - - ko:K00406 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00156 - - ko00000,ko00001,ko00002 3.D.4.3 - - Cytochrome_CBB3,FixP_N k59_1453087_1 1265313.HRUBRA_02356 1.71e-39 146.0 COG2274@1|root,COG2274@2|Bacteria,1R2T0@1224|Proteobacteria,1SBE1@1236|Gammaproteobacteria,1J5FP@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria V COG2274 ABC-type bacteriocin lantibiotic exporters, contain an N-terminal double-glycine peptidase domain - - - ko:K12541 ko02010,map02010 M00330 - - ko00000,ko00001,ko00002,ko02000,ko02044 3.A.1.109.3,3.A.1.109.4 - - ABC_membrane,ABC_tran,Peptidase_C39 k59_1453087_2 1121937.AUHJ01000015_gene153 4.06e-106 327.0 COG0845@1|root,COG0845@2|Bacteria,1MUI8@1224|Proteobacteria,1RNK4@1236|Gammaproteobacteria,464KG@72275|Alteromonadaceae 1236|Gammaproteobacteria M Secretion protein - - - ko:K12542 - M00330 - - ko00000,ko00002,ko02000,ko02044 3.A.1.109.4,8.A.1 - - Biotin_lipoyl_2,HlyD,HlyD_3 k59_610270_1 1096546.WYO_0074 9.1e-36 129.0 COG0723@1|root,COG0723@2|Bacteria,1RF8Q@1224|Proteobacteria,2U5KE@28211|Alphaproteobacteria 28211|Alphaproteobacteria C arsenite oxidase, small subunit - - 1.20.2.1,1.20.9.1 ko:K08355 - - - - ko00000,ko01000,ko02000 5.A.3.6 - - Rieske,TAT_signal k59_610270_2 247633.GP2143_13216 7.39e-11 64.7 COG2159@1|root,COG2159@2|Bacteria,1RK9M@1224|Proteobacteria,1S78V@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Amidohydrolase - - - - - - - - - - - - Amidohydro_2 k59_1339587_1 76114.ebA7188 3e-27 111.0 COG4783@1|root,COG4783@2|Bacteria,1MVFV@1224|Proteobacteria,2VHAY@28216|Betaproteobacteria,2KUIC@206389|Rhodocyclales 206389|Rhodocyclales S Peptidase M48 - - - - - - - - - - - - Peptidase_M48,TPR_16,TPR_19 k59_1339587_2 1177179.A11A3_10247 7.77e-41 146.0 COG2046@1|root,COG2046@2|Bacteria,1MUQB@1224|Proteobacteria,1RP4Q@1236|Gammaproteobacteria 1236|Gammaproteobacteria P Belongs to the sulfate adenylyltransferase family sat - 2.7.7.4 ko:K00958 ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130 M00176,M00596 R00529,R04929 RC02809,RC02889 ko00000,ko00001,ko00002,ko01000 - - - ATP-sulfurylase,PUA_2 k59_1572152_1 765913.ThidrDRAFT_0849 3.85e-10 59.3 COG0589@1|root,COG0589@2|Bacteria,1NB6E@1224|Proteobacteria,1SEN6@1236|Gammaproteobacteria,1WZ7A@135613|Chromatiales 135613|Chromatiales T Belongs to the universal stress protein A family - - - - - - - - - - - - Usp k59_1572152_2 502025.Hoch_2280 5.57e-07 52.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,2Z2X4@29|Myxococcales 28221|Deltaproteobacteria T Bacterial regulatory protein, Fis family - - - ko:K02481,ko:K07713 ko02020,map02020 M00499 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_436383_1 102232.GLO73106DRAFT_00009400 2.9e-23 98.2 COG0065@1|root,COG0065@2|Bacteria,1G1J0@1117|Cyanobacteria 1117|Cyanobacteria E Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate leuC - 4.2.1.33,4.2.1.35 ko:K01703 ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230 M00432,M00535 R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170 RC00497,RC00976,RC00977,RC01041,RC01046,RC03072 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase k59_1283282_2 1453501.JELR01000002_gene1249 2.14e-32 113.0 COG0254@1|root,COG0254@2|Bacteria,1MZ69@1224|Proteobacteria,1SCMH@1236|Gammaproteobacteria,468J3@72275|Alteromonadaceae 1236|Gammaproteobacteria J Binds the 23S rRNA rpmE GO:0003674,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046872,GO:0046914,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02909 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L31 k59_436385_1 702113.PP1Y_AT17109 7.25e-124 364.0 COG0201@1|root,COG0201@2|Bacteria,1MVU7@1224|Proteobacteria,2TQMT@28211|Alphaproteobacteria,2JZY0@204457|Sphingomonadales 204457|Sphingomonadales U The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently secY - - ko:K03076 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5 - - SecY k59_1514897_1 1198114.AciX9_2884 1.91e-08 55.8 COG0366@1|root,COG3281@1|root,COG0366@2|Bacteria,COG3281@2|Bacteria,3Y2RE@57723|Acidobacteria,2JHM7@204432|Acidobacteriia 204432|Acidobacteriia G Maltogenic Amylase, C-terminal domain - - 3.2.1.1,5.4.99.16 ko:K05343 ko00500,ko01100,map00500,map01100 - R01557,R02108,R02112,R11262 RC01816 ko00000,ko00001,ko01000 - GH13 - Alpha-amylase,Malt_amylase_C k59_1514897_2 264732.Moth_1809 1.64e-105 327.0 COG0296@1|root,COG0296@2|Bacteria,1TP4M@1239|Firmicutes,247WH@186801|Clostridia,42FTG@68295|Thermoanaerobacterales 186801|Clostridia G Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position glgB - 2.4.1.18,3.2.1.141 ko:K00700,ko:K01236 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R02110,R09995,R11256 RC00049 ko00000,ko00001,ko00002,ko01000,ko04147 - CBM48,GH13 - Alpha-amylase,Alpha-amylase_C,CBM_48,DUF3459 k59_1339601_1 1122137.AQXF01000002_gene247 3.14e-73 223.0 COG0669@1|root,COG0669@2|Bacteria,1RD9F@1224|Proteobacteria,2U74H@28211|Alphaproteobacteria 28211|Alphaproteobacteria H Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate coaD - 2.7.7.3 ko:K00954 ko00770,ko01100,map00770,map01100 M00120 R03035 RC00002 ko00000,ko00001,ko00002,ko01000 - - - CTP_transf_like k59_1339601_2 754477.Q7C_633 1.23e-29 112.0 COG1585@1|root,COG1585@2|Bacteria,1N241@1224|Proteobacteria,1S5W4@1236|Gammaproteobacteria,462TR@72273|Thiotrichales 72273|Thiotrichales OU of membrane protease - - - ko:K07340 - - - - ko00000 - - - NfeD k59_328598_1 1397528.Q671_09950 1.66e-32 119.0 COG3194@1|root,COG3194@2|Bacteria,1RH5G@1224|Proteobacteria,1T0X7@1236|Gammaproteobacteria,1XKNF@135619|Oceanospirillales 135619|Oceanospirillales F Ureidoglycolate lyase allA - 4.3.2.3 ko:K01483 ko00230,ko01100,map00230,map01100 - R00776 RC00153,RC00379 ko00000,ko00001,ko01000 - - - Ureidogly_lyase k59_1624948_2 28444.JODQ01000006_gene63 2.74e-32 122.0 COG2519@1|root,COG2519@2|Bacteria,2GMKZ@201174|Actinobacteria,4EIDW@85012|Streptosporangiales 201174|Actinobacteria J O-methyltransferase - - - - - - - - - - - - Methyltransf_11,Methyltransf_25,Methyltransf_31 k59_45048_1 794903.OPIT5_17600 1.29e-26 107.0 COG0539@1|root,COG0539@2|Bacteria,46SFY@74201|Verrucomicrobia,3K7E8@414999|Opitutae 414999|Opitutae J thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence - - - ko:K02945 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - S1 k59_155639_1 436308.Nmar_0111 9.93e-67 204.0 COG0432@1|root,arCOG04214@2157|Archaea,41T31@651137|Thaumarchaeota 651137|Thaumarchaeota S Uncharacterised protein family UPF0047 - - - - - - - - - - - - UPF0047 k59_155639_2 1229909.NSED_00260 1.3e-27 100.0 arCOG08724@1|root,arCOG08724@2157|Archaea,41TA8@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_952919_1 316407.85676877 5.58e-185 525.0 COG3290@1|root,COG3290@2|Bacteria,1MXQ5@1224|Proteobacteria,1RNRF@1236|Gammaproteobacteria,3XMMT@561|Escherichia 1236|Gammaproteobacteria T Member of the two-component regulatory system DcuR DcuS. Involved in the C4-dicarboxylate-stimulated regulation of the genes encoding the anaerobic fumarate respiratory system (frdABCD dcuS GO:0000155,GO:0000160,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006355,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0016020,GO:0016021,GO:0016043,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0018106,GO:0018193,GO:0018202,GO:0019219,GO:0019222,GO:0019538,GO:0022607,GO:0023014,GO:0023052,GO:0031224,GO:0031226,GO:0031323,GO:0031326,GO:0035556,GO:0036211,GO:0042802,GO:0043170,GO:0043412,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0051259,GO:0051260,GO:0051716,GO:0060255,GO:0065003,GO:0065007,GO:0071704,GO:0071840,GO:0071944,GO:0080090,GO:0140096,GO:1901564,GO:1903506,GO:2000112,GO:2001141 2.7.13.3 ko:K02476,ko:K07701,ko:K11614 ko02020,map02020 M00488,M00490 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,PAS,SPOB_a,sCache_3_2 k59_952919_2 316407.85676876 3.27e-20 85.9 COG4565@1|root,COG4565@2|Bacteria,1MUC7@1224|Proteobacteria,1RNEF@1236|Gammaproteobacteria,3XN3Z@561|Escherichia 1236|Gammaproteobacteria K Member of the two-component regulatory system DcuR DcuS. Involved in the C4-dicarboxylate-stimulated regulation of the genes encoding the anaerobic fumarate respiratory system (frdABCD dcuR GO:0000160,GO:0001121,GO:0001130,GO:0001131,GO:0001140,GO:0001216,GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0005488,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0023052,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0035556,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0045893,GO:0045935,GO:0046483,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051716,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141 - ko:K02475,ko:K07703,ko:K11615 ko02020,map02020 M00488,M00490 - - ko00000,ko00001,ko00002,ko02022 - - - CitT,Response_reg k59_499930_1 436308.Nmar_0300 5.71e-112 329.0 COG3958@1|root,arCOG01051@2157|Archaea,41SEP@651137|Thaumarchaeota 651137|Thaumarchaeota G Transketolase, pyrimidine binding domain - - 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 - - - Transket_pyr,Transketolase_C k59_336767_1 1499968.TCA2_1928 6.11e-13 72.8 COG0667@1|root,COG0667@2|Bacteria,1V300@1239|Firmicutes,4HERM@91061|Bacilli,26TBI@186822|Paenibacillaceae 91061|Bacilli C aldo keto reductase - - - - - - - - - - - - Aldo_ket_red k59_1745637_1 1104324.P186_2852 1.16e-39 144.0 COG1748@1|root,arCOG00243@2157|Archaea,2XQJJ@28889|Crenarchaeota 28889|Crenarchaeota C Saccharopine dehydrogenase - - - - - - - - - - - - Sacchrp_dh_C,Sacchrp_dh_NADP,Semialdhyde_dh,UDPG_MGDP_dh_N k59_1069693_1 1184267.A11Q_1274 7.02e-63 206.0 COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,42MSR@68525|delta/epsilon subdivisions,2MSP4@213481|Bdellovibrionales,2WIXG@28221|Deltaproteobacteria 213481|Bdellovibrionales I Belongs to the thiolase family bamN - 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N k59_1523052_1 756272.Plabr_3615 1.14e-58 213.0 COG0004@1|root,COG0784@1|root,COG2198@1|root,COG5002@1|root,COG0004@2|Bacteria,COG0784@2|Bacteria,COG2198@2|Bacteria,COG5002@2|Bacteria,2J4Z7@203682|Planctomycetes 203682|Planctomycetes T SMART ATP-binding region ATPase domain protein - - - ko:K03320 - - - - ko00000,ko02000 1.A.11 - - Ammonium_transp,HATPase_c,HisKA,Hpt,PAS_9,Response_reg k59_902066_1 161528.ED21_32124 7.92e-37 136.0 COG2801@1|root,COG2801@2|Bacteria,1MVN5@1224|Proteobacteria,2TQK0@28211|Alphaproteobacteria,2K2F6@204457|Sphingomonadales 204457|Sphingomonadales L COG2801 Transposase and inactivated derivatives - - - - - - - - - - - - HTH_21,rve,rve_3 k59_1410794_1 65393.PCC7424_0450 4.97e-16 75.5 COG2110@1|root,COG2110@2|Bacteria,1G5VN@1117|Cyanobacteria,3KHWD@43988|Cyanothece 1117|Cyanobacteria S Appr-1-p processing domain - - - - - - - - - - - - Macro k59_1410794_2 42565.FP66_11510 4.68e-41 153.0 COG0045@1|root,COG1042@1|root,COG1670@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,COG1670@2|Bacteria,1MW98@1224|Proteobacteria,1RPXX@1236|Gammaproteobacteria,1XHR6@135619|Oceanospirillales 135619|Oceanospirillales C Succinyl-CoA ligase like flavodoxin domain - - - ko:K09181 - - - - ko00000 - - - ATP-grasp_5,Acetyltransf_1,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig k59_1797998_1 748247.AZKH_4595 3.09e-102 300.0 COG0410@1|root,COG0410@2|Bacteria,1MU4Z@1224|Proteobacteria,2VJUP@28216|Betaproteobacteria,2KV7I@206389|Rhodocyclales 206389|Rhodocyclales E ABC transporter, ATP-binding protein urtE - - ko:K11963 ko02010,map02010 M00323 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4.4,3.A.1.4.5 - - ABC_tran k59_221050_1 314282.PCNPT3_10090 1.57e-93 296.0 COG1331@1|root,COG1331@2|Bacteria,1R6MC@1224|Proteobacteria,1S0AF@1236|Gammaproteobacteria 1236|Gammaproteobacteria O Highly conserved protein containing a thioredoxin domain - - - - - - - - - - - - - k59_1798001_1 1229909.NSED_01120 1.18e-69 229.0 COG1241@1|root,arCOG00439@2157|Archaea,41SA7@651137|Thaumarchaeota 651137|Thaumarchaeota L Belongs to the MCM family - - - ko:K10726 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - MCM,MCM_N,MCM_OB k59_1798001_2 1229909.NSED_01115 2.61e-16 75.1 arCOG00552@1|root,arCOG00552@2157|Archaea,41SRW@651137|Thaumarchaeota 651137|Thaumarchaeota L GINS complex protein - - - ko:K09723 - - - - ko00000,ko03032 - - - Sld5 k59_393820_1 247634.GPB2148_2215 1.47e-94 290.0 COG0147@1|root,COG0147@2|Bacteria,1MVBJ@1224|Proteobacteria,1RMSE@1236|Gammaproteobacteria,1J5AP@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia trpE - 4.1.3.27 ko:K01657 ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025 M00023 R00985,R00986 RC00010,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 - - iJN746.PP_0417 Anth_synt_I_N,Chorismate_bind k59_1688670_2 332101.JIBU02000020_gene2070 6.84e-45 160.0 COG0246@1|root,COG0246@2|Bacteria,1TPZU@1239|Firmicutes,248J5@186801|Clostridia,36FPY@31979|Clostridiaceae 186801|Clostridia G Belongs to the mannitol dehydrogenase family. UxaB subfamily uxaB - 1.1.1.58 ko:K00041 ko00040,ko01100,map00040,map01100 M00631 R02555 RC00085 ko00000,ko00001,ko00002,ko01000 - - - Mannitol_dh,Mannitol_dh_C k59_841925_1 1179773.BN6_56400 3.23e-21 99.0 COG0045@1|root,COG1042@1|root,COG1247@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,COG1247@2|Bacteria,2GKN1@201174|Actinobacteria,4DZ1D@85010|Pseudonocardiales 201174|Actinobacteria C CoA binding domain - - - - - - - - - - - - ATP-grasp_5,Acetyltransf_1,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig k59_1461778_1 768671.ThimaDRAFT_4319 8.82e-40 139.0 COG0494@1|root,COG0494@2|Bacteria,1RCX7@1224|Proteobacteria,1RSM2@1236|Gammaproteobacteria,1WX5K@135613|Chromatiales 135613|Chromatiales L Belongs to the Nudix hydrolase family - - 3.6.1.13 ko:K01515 ko00230,map00230 - R01054 RC00002 ko00000,ko00001,ko01000 - - - NUDIX k59_841936_1 316407.85675816 9.6e-79 239.0 COG0656@1|root,COG0656@2|Bacteria,1MWFS@1224|Proteobacteria,1RMX6@1236|Gammaproteobacteria,3XMUT@561|Escherichia 1236|Gammaproteobacteria S Catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG) dkgA GO:0003674,GO:0003824,GO:0004033,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0008106,GO:0008150,GO:0008152,GO:0009056,GO:0009438,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0042180,GO:0042182,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046185,GO:0047681,GO:0051596,GO:0055114,GO:0071704,GO:1901575,GO:1990002 1.1.1.346 ko:K06221,ko:K06222 - - R08878 RC00089 ko00000,ko01000 - - iECH74115_1262.ECH74115_4323,iECSP_1301.ECSP_3988,iEcolC_1368.EcolC_3458 Aldo_ket_red k59_841936_2 316407.85675815 4.27e-18 82.0 COG1979@1|root,COG1979@2|Bacteria,1QUBJ@1224|Proteobacteria,1RP7C@1236|Gammaproteobacteria,3XP5X@561|Escherichia 1236|Gammaproteobacteria C alcohol dehydrogenase [NAD(P)+] activity yqhD GO:0000302,GO:0003674,GO:0003824,GO:0004033,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006979,GO:0008106,GO:0008150,GO:0008152,GO:0008270,GO:0016491,GO:0016614,GO:0016616,GO:0018455,GO:0042221,GO:0043167,GO:0043169,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0050896,GO:0055114,GO:1901700,GO:1990002 - ko:K08325 ko00640,map00640 - R02528 RC00739 ko00000,ko00001,ko01000 - - - Fe-ADH k59_279130_1 436308.Nmar_0956 2.73e-29 108.0 arCOG08685@1|root,arCOG08685@2157|Archaea,41T67@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_279130_2 436308.Nmar_0955 1.7e-53 176.0 COG1703@1|root,arCOG01226@2157|Archaea,41SFN@651137|Thaumarchaeota 651137|Thaumarchaeota E LAO AO transport system ATPase - - - ko:K07588 - - - - ko00000,ko01000 - - - ArgK k59_1580681_1 702113.PP1Y_AT35386 4.12e-49 166.0 COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,2TRPK@28211|Alphaproteobacteria,2K0HJ@204457|Sphingomonadales 204457|Sphingomonadales E Catalyzes the formation of oxalozcetate and L-glutamate from L-aspartate and 2-oxoglutarate aspB - 2.6.1.1 ko:K00812 ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230 - R00355,R00694,R00734,R00896,R02433,R02619,R05052 RC00006 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_1_2 k59_1580681_2 702113.PP1Y_AT35400 1.19e-102 301.0 COG0564@1|root,COG0564@2|Bacteria,1MVJ5@1224|Proteobacteria,2TSCG@28211|Alphaproteobacteria,2K0XZ@204457|Sphingomonadales 204457|Sphingomonadales J Pseudouridine synthase - - 5.4.99.28,5.4.99.29 ko:K06177 - - - - ko00000,ko01000,ko03009,ko03016 - - - PseudoU_synth_2 k59_1688713_1 1349767.GJA_2333 2.3e-30 123.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,2VGZ8@28216|Betaproteobacteria,475ZU@75682|Oxalobacteraceae 28216|Betaproteobacteria NT methyl-accepting chemotaxis - - - ko:K03406,ko:K03776,ko:K05875 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - 4HB_MCP_1,HAMP,MCPsignal,PAS_3 k59_1122719_1 1415778.JQMM01000001_gene838 1.01e-118 351.0 COG0766@1|root,COG0766@2|Bacteria,1MUH7@1224|Proteobacteria,1RN91@1236|Gammaproteobacteria,1J56Z@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Belongs to the EPSP synthase family. MurA subfamily murA GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008760,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016740,GO:0016765,GO:0030203,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 2.5.1.7 ko:K00790 ko00520,ko00550,ko01100,map00520,map00550,map01100 - R00660 RC00350 ko00000,ko00001,ko01000,ko01011 - - - EPSP_synthase k59_1410832_1 1183377.Py04_1756 7.04e-06 53.1 COG0582@1|root,arCOG01241@2157|Archaea,2XV3E@28890|Euryarchaeota,242ZK@183968|Thermococci 183968|Thermococci J Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules xerA - - ko:K04763 - - - - ko00000,ko03036 - - - Phage_int_SAM_1,Phage_int_SAM_4,Phage_integrase k59_619061_1 1144305.PMI02_05318 5.27e-10 58.9 COG1109@1|root,COG1109@2|Bacteria,1MU24@1224|Proteobacteria,2TQWH@28211|Alphaproteobacteria,2JZV4@204457|Sphingomonadales 204457|Sphingomonadales G Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate glmM - 5.4.2.10 ko:K03431 ko00520,ko01100,ko01130,map00520,map01100,map01130 - R02060 RC00408 ko00000,ko00001,ko01000 - - - PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV k59_619061_2 279238.Saro_0482 4.61e-12 68.6 COG1301@1|root,COG1301@2|Bacteria,1MVID@1224|Proteobacteria,2TUR0@28211|Alphaproteobacteria,2K09V@204457|Sphingomonadales 204457|Sphingomonadales C Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family - - - - - - - - - - - - SDF k59_841951_1 1424334.W822_08075 1.48e-79 251.0 COG0015@1|root,COG0015@2|Bacteria,1MXNN@1224|Proteobacteria,2VID3@28216|Betaproteobacteria,3T2DT@506|Alcaligenaceae 28216|Betaproteobacteria F Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily - - 4.3.2.2,5.5.1.2 ko:K01756,ko:K01857 ko00230,ko00250,ko00362,ko01100,ko01110,ko01120,ko01130,ko01220,map00230,map00250,map00362,map01100,map01110,map01120,map01130,map01220 M00048,M00049 R01083,R03307,R04559 RC00379,RC00444,RC00445,RC00902 ko00000,ko00001,ko00002,ko01000 - - - ADSL_C,Lyase_1 k59_1237214_1 867900.Celly_0848 5.84e-78 236.0 COG2839@1|root,COG2839@2|Bacteria,4NNIY@976|Bacteroidetes,1I3ED@117743|Flavobacteriia,1F94H@104264|Cellulophaga 976|Bacteroidetes S Protein of unknown function (DUF456) - - - ko:K09793 - - - - ko00000 - - - DUF456 k59_1410842_1 555793.WSK_2700 4.01e-150 431.0 COG4948@1|root,COG4948@2|Bacteria,1MURK@1224|Proteobacteria,2TV84@28211|Alphaproteobacteria,2JZUU@204457|Sphingomonadales 204457|Sphingomonadales M Belongs to the mandelate racemase muconate lactonizing enzyme family - GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005975,GO:0008150,GO:0008152,GO:0008927,GO:0009056,GO:0016052,GO:0016829,GO:0016835,GO:0016836,GO:0043167,GO:0043169,GO:0044238,GO:0046872,GO:0071704,GO:1901575 4.2.1.8 ko:K08323 ko00040,ko01100,map00040,map01100 M00061 R05606 RC00543 ko00000,ko00001,ko00002,ko01000 - - - MR_MLE_C,MR_MLE_N k59_393854_1 203122.Sde_1643 2.85e-95 290.0 COG0006@1|root,COG0006@2|Bacteria,1MWUT@1224|Proteobacteria,1RZSD@1236|Gammaproteobacteria,4658E@72275|Alteromonadaceae 1236|Gammaproteobacteria E COG0006 Xaa-Pro aminopeptidase - - 3.4.13.9 ko:K01271 - - - - ko00000,ko01000,ko01002 - - - Creatinase_N,Peptidase_M24 k59_1523111_1 1379270.AUXF01000001_gene2734 4.62e-37 139.0 COG0841@1|root,COG0841@2|Bacteria,1ZUDY@142182|Gemmatimonadetes 142182|Gemmatimonadetes V Protein export membrane protein - - - - - - - - - - - - ACR_tran k59_1523111_2 1249997.JHZW01000003_gene3329 2.96e-07 53.1 COG0845@1|root,COG0845@2|Bacteria,4NF23@976|Bacteroidetes,1HZGV@117743|Flavobacteriia,2PIIU@252356|Maribacter 976|Bacteroidetes M Biotin-lipoyl like - - - - - - - - - - - - HlyD_D23 k59_1292070_2 436308.Nmar_1760 1.57e-57 182.0 COG2453@1|root,arCOG03413@2157|Archaea,41SK5@651137|Thaumarchaeota 651137|Thaumarchaeota T Dual specificity phosphatase, catalytic domain - - 3.1.3.16,3.1.3.48 ko:K14165 - - - - ko00000,ko01000,ko01009 - - - DSPc k59_1580695_1 1120983.KB894575_gene468 1.8e-44 153.0 COG4176@1|root,COG4176@2|Bacteria,1MUM4@1224|Proteobacteria,2TRF1@28211|Alphaproteobacteria,1JNXC@119043|Rhodobiaceae 28211|Alphaproteobacteria P L-proline glycine betaine ABC transport system permease protein ProW - - - ko:K02001,ko:K02002 ko02010,map02010 M00208 - - ko00000,ko00001,ko00002,ko02000 3.A.1.12 - - BPD_transp_1,OpuAC k59_1580695_2 1007105.PT7_1633 9.26e-24 99.4 COG0517@1|root,COG4175@1|root,COG0517@2|Bacteria,COG4175@2|Bacteria,1MU86@1224|Proteobacteria,2VJMH@28216|Betaproteobacteria,3T2BD@506|Alcaligenaceae 28216|Betaproteobacteria E glycine betaine proV - 3.6.3.32 ko:K02000 ko02010,map02010 M00208 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.12 - - ABC_tran k59_902125_1 472759.Nhal_3505 1.03e-35 137.0 COG1538@1|root,COG1538@2|Bacteria,1MWCJ@1224|Proteobacteria,1RQQV@1236|Gammaproteobacteria,1WVXZ@135613|Chromatiales 135613|Chromatiales MU type I secretion outer membrane protein, TolC - - - ko:K12340 ko01501,ko01503,ko02020,ko03070,ko04626,ko05133,map01501,map01503,map02020,map03070,map04626,map05133 M00325,M00326,M00339,M00571,M00575,M00646,M00647,M00696,M00697,M00709,M00720,M00821 - - ko00000,ko00001,ko00002,ko01504,ko02000,ko02044 1.B.17,2.A.6.2 - - OEP k59_1461830_1 1049564.TevJSym_ao00720 0.000408 43.9 COG0768@1|root,COG0768@2|Bacteria,1MV8C@1224|Proteobacteria,1RN9H@1236|Gammaproteobacteria,1J4EU@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Catalyzes cross-linking of the peptidoglycan cell wall mrdA GO:0000270,GO:0003674,GO:0003824,GO:0004180,GO:0004185,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006022,GO:0006023,GO:0006024,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0008238,GO:0008360,GO:0008658,GO:0009002,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016021,GO:0016043,GO:0016787,GO:0017171,GO:0019538,GO:0022603,GO:0022604,GO:0030203,GO:0031224,GO:0031226,GO:0031406,GO:0033218,GO:0033293,GO:0034645,GO:0036094,GO:0042221,GO:0042493,GO:0042546,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044425,GO:0044459,GO:0044464,GO:0045229,GO:0046677,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051128,GO:0065007,GO:0065008,GO:0070008,GO:0070011,GO:0070589,GO:0071554,GO:0071555,GO:0071704,GO:0071840,GO:0071944,GO:0071972,GO:0097159,GO:0140096,GO:1901135,GO:1901137,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901681 3.4.16.4 ko:K05515 ko00550,ko01501,map00550,map01501 - - - ko00000,ko00001,ko01000,ko01011 - - iEcE24377_1341.EcE24377A_0661,iPC815.YPO2604 PBP_dimer,Transpeptidase k59_1461830_2 1163409.UUA_12228 1.11e-46 156.0 COG2891@1|root,COG2891@2|Bacteria,1RER7@1224|Proteobacteria,1S26R@1236|Gammaproteobacteria,1X6PV@135614|Xanthomonadales 135614|Xanthomonadales M Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins mreD - - ko:K03571 - - - - ko00000,ko03036 9.B.157.1 - - MreD k59_1410856_1 330214.NIDE3255 4.13e-130 402.0 COG0243@1|root,COG0243@2|Bacteria 2|Bacteria C molybdopterin cofactor binding ddhA GO:0005575,GO:0005623,GO:0042597,GO:0044464 1.17.99.2,1.7.5.1,1.8.2.4 ko:K00370,ko:K10700,ko:K16964,ko:K17050 ko00642,ko00910,ko00920,ko01100,ko01120,ko01220,ko02020,map00642,map00910,map00920,map01100,map01120,map01220,map02020 M00529,M00530,M00804 R00798,R01106,R05745,R09497,R09500 RC00275,RC02555,RC02812 ko00000,ko00001,ko00002,ko01000,ko02000 5.A.3.1,5.A.3.8,5.A.3.9 - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding,TAT_signal k59_1798035_1 714083.JH370377_gene1763 5.85e-76 245.0 COG0489@1|root,COG0489@2|Bacteria,2GJUZ@201174|Actinobacteria,4FKNN@85023|Microbacteriaceae 201174|Actinobacteria D Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP mrp GO:0008150,GO:0040007 - ko:K03593 - - - - ko00000,ko03029,ko03036 - - - FeS_assembly_P,ParA k59_1633479_1 1123368.AUIS01000032_gene1397 7.21e-40 145.0 COG0412@1|root,COG0412@2|Bacteria,1MW7S@1224|Proteobacteria,1RPGK@1236|Gammaproteobacteria,2NCSK@225057|Acidithiobacillales 225057|Acidithiobacillales Q Prolyl oligopeptidase family - - 3.1.1.45 ko:K01061 ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130 - R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222 RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686 ko00000,ko00001,ko01000 - - - DLH,Peptidase_S9 k59_902133_1 1168034.FH5T_08540 3.44e-149 441.0 COG0366@1|root,COG0366@2|Bacteria,4NEXF@976|Bacteroidetes,2FMHS@200643|Bacteroidia 976|Bacteroidetes G Belongs to the glycosyl hydrolase 13 family amyA2 GO:0003674,GO:0003824,GO:0004553,GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0016787,GO:0016798,GO:0031216,GO:0044464,GO:0071944 3.2.1.135 ko:K21575 - - - - ko00000,ko01000 - GH13 - Alpha-amylase,Cyc-maltodext_C,Cyc-maltodext_N k59_1348142_1 1382359.JIAL01000001_gene1431 3.69e-79 247.0 COG0476@1|root,COG0476@2|Bacteria,3Y3IF@57723|Acidobacteria,2JIPC@204432|Acidobacteriia 204432|Acidobacteriia HP PFAM UBA THIF-type NAD FAD binding - - 2.7.7.80,2.8.1.11 ko:K21147 ko04122,map04122 - R07459,R07461 RC00043 ko00000,ko00001,ko01000 - - - Rhodanese,ThiF,ThiS k59_1580712_1 883078.HMPREF9695_00713 2.12e-120 356.0 COG0074@1|root,COG0074@2|Bacteria,1MX67@1224|Proteobacteria,2U0AT@28211|Alphaproteobacteria,3JX2B@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria C Protein of unknown function (DUF1116) - - - - - - - - - - - - DUF1116 k59_1461840_1 330214.NIDE0860 5.85e-38 149.0 COG1196@1|root,COG1196@2|Bacteria,3J0W4@40117|Nitrospirae 40117|Nitrospirae D Required for chromosome condensation and partitioning smc - - ko:K03529 - - - - ko00000,ko03036 - - - SMC_N k59_555952_1 1122137.AQXF01000001_gene2663 4.19e-26 107.0 COG0398@1|root,COG0398@2|Bacteria,1RBAE@1224|Proteobacteria,2U6B6@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Protein of unknown function, DUF547 - - - - - - - - - - - - DUF547 k59_279182_1 395494.Galf_0476 1.91e-99 295.0 COG1947@1|root,COG1947@2|Bacteria,1MVU3@1224|Proteobacteria,2VHK3@28216|Betaproteobacteria,44V4C@713636|Nitrosomonadales 28216|Betaproteobacteria I Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol ispE - 2.7.1.148 ko:K00919 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05634 RC00002,RC01439 ko00000,ko00001,ko00002,ko01000 - - - GHMP_kinases_C,GHMP_kinases_N k59_1348161_1 1122137.AQXF01000003_gene2137 7.95e-141 412.0 COG0642@1|root,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,2TRHH@28211|Alphaproteobacteria 28211|Alphaproteobacteria T Histidine kinase - - - - - - - - - - - - HATPase_c,HisKA,PAS_4,PAS_7 k59_670993_1 272943.RSP_2446 1.81e-74 249.0 COG0366@1|root,COG3281@1|root,COG0366@2|Bacteria,COG3281@2|Bacteria,1MVKX@1224|Proteobacteria,2TRS3@28211|Alphaproteobacteria,1FCD3@1060|Rhodobacter 28211|Alphaproteobacteria G PFAM alpha amylase, catalytic treS - 3.2.1.1,5.4.99.16 ko:K05343 ko00500,ko01100,map00500,map01100 - R01557,R02108,R02112,R11262 RC01816 ko00000,ko00001,ko01000 - GH13 - APH,Alpha-amylase,Malt_amylase_C k59_619094_1 1144932.ATTF01000008_gene472 6.76e-38 142.0 COG0019@1|root,COG0019@2|Bacteria,1MZ7Y@1224|Proteobacteria,2TSKB@28211|Alphaproteobacteria,4BP9T@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria E Pyridoxal-dependent decarboxylase, pyridoxal binding domain ldc - 4.1.1.17 ko:K01581 ko00330,ko00480,ko01100,ko01110,ko01130,map00330,map00480,map01100,map01110,map01130 M00134 R00670 RC00299 ko00000,ko00001,ko00002,ko01000 - - - Orn_Arg_deC_N,Orn_DAP_Arg_deC k59_1580715_1 330214.NIDE4091 2.93e-19 92.8 COG3419@1|root,COG3419@2|Bacteria,3J100@40117|Nitrospirae 40117|Nitrospirae NU Tfp pilus assembly protein tip-associated adhesin - - - ko:K02674 - - - - ko00000,ko02035,ko02044 - - - Neisseria_PilC k59_619098_1 377629.TERTU_0940 1.64e-66 220.0 COG0297@1|root,COG0297@2|Bacteria,1MUGM@1224|Proteobacteria,1RNMP@1236|Gammaproteobacteria,2PNV2@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria G Starch synthase catalytic domain glgA GO:0000271,GO:0003674,GO:0003824,GO:0004373,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0006073,GO:0006091,GO:0006112,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008194,GO:0009011,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0015980,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033554,GO:0033692,GO:0034637,GO:0034645,GO:0035251,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0046527,GO:0050896,GO:0051716,GO:0055114,GO:0071704,GO:1901576 2.4.1.21 ko:K00703 ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026 M00565 R02421 RC00005 ko00000,ko00001,ko00002,ko01000,ko01003 - GT5 iSFV_1184.SFV_3438 Glyco_transf_5,Glycos_transf_1 k59_1008386_1 1304883.KI912532_gene1917 5.39e-82 256.0 COG0137@1|root,COG0137@2|Bacteria,1MV0Y@1224|Proteobacteria,2VJ7Z@28216|Betaproteobacteria,2KUUD@206389|Rhodocyclales 206389|Rhodocyclales E Belongs to the argininosuccinate synthase family. Type 1 subfamily argG - 6.3.4.5 ko:K01940 ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418 M00029,M00844,M00845 R01954 RC00380,RC00629 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Arginosuc_synth k59_902174_1 710686.Mycsm_01635 2.31e-61 207.0 COG0346@1|root,COG0346@2|Bacteria,2IP2W@201174|Actinobacteria,23B6D@1762|Mycobacteriaceae 201174|Actinobacteria E lactoylglutathione lyase activity - - - - - - - - - - - - Glyoxalase_4,Polyketide_cyc2 k59_732181_1 1080067.BAZH01000021_gene2915 3.5e-11 65.1 28KZZ@1|root,2ZAF4@2|Bacteria,1R6SC@1224|Proteobacteria,1RR2K@1236|Gammaproteobacteria,3WYJ2@544|Citrobacter 1236|Gammaproteobacteria S Protein of unknown function (DUF1367) - - - - - - - - - - - - DUF1367 k59_279968_1 1096930.L284_08140 3.51e-126 364.0 COG0266@1|root,COG0266@2|Bacteria,1MVM5@1224|Proteobacteria,2TS4C@28211|Alphaproteobacteria,2K2A5@204457|Sphingomonadales 204457|Sphingomonadales L Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates fpg - 3.2.2.23,4.2.99.18 ko:K10563 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - Fapy_DNA_glyco,H2TH,zf-FPG_IleRS k59_1523938_1 1415778.JQMM01000001_gene2014 5.05e-119 356.0 COG0539@1|root,COG0539@2|Bacteria,1MVAV@1224|Proteobacteria,1RMFY@1236|Gammaproteobacteria,1J51F@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence rpsA GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006417,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015935,GO:0016043,GO:0017148,GO:0019222,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065003,GO:0065007,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0080090,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904,GO:2000112,GO:2000113,GO:2000765,GO:2000766 - ko:K02945 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - S1 k59_1411633_1 744980.TRICHSKD4_1576 1.1e-40 139.0 COG0799@1|root,COG0799@2|Bacteria,1MZEF@1224|Proteobacteria,2UBSV@28211|Alphaproteobacteria 28211|Alphaproteobacteria J Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation rsfS - - ko:K09710 - - - - ko00000,ko03009 - - - RsfS k59_1411633_2 314264.ROS217_16125 1.05e-24 100.0 COG1057@1|root,COG1057@2|Bacteria,1RD0J@1224|Proteobacteria,2U6ZC@28211|Alphaproteobacteria,46NYW@74030|Roseovarius 28211|Alphaproteobacteria H Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) nadD - 2.7.7.18 ko:K00969 ko00760,ko01100,map00760,map01100 M00115 R00137,R03005 RC00002 ko00000,ko00001,ko00002,ko01000 - - - CTP_transf_like k59_1292843_2 998674.ATTE01000001_gene1715 1.56e-45 159.0 COG0436@1|root,COG0436@2|Bacteria,1MWS8@1224|Proteobacteria,1RPGJ@1236|Gammaproteobacteria,461WN@72273|Thiotrichales 72273|Thiotrichales E PFAM Aminotransferase class I and II - - 2.6.1.17 ko:K14267 ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230 M00016 R04475 RC00006 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 k59_671836_1 400682.PAC_15705790 2.44e-101 320.0 COG0843@1|root,COG1622@1|root,KOG4767@2759|Eukaryota,KOG4769@2759|Eukaryota,38JQ7@33154|Opisthokonta,3BGCX@33208|Metazoa 33208|Metazoa C electron transport coupled proton transport - - - - - - - - - - - - COX1,COX2 k59_671836_2 998674.ATTE01000001_gene2455 6.24e-05 44.7 COG1622@1|root,COG1622@2|Bacteria,1MWHZ@1224|Proteobacteria,1RP4H@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) coxB - 1.9.3.1 ko:K02275 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.4,3.D.4.6 - - COX2,COX2_TM,Cytochrome_CBB3 k59_1348864_1 314278.NB231_08127 7.78e-155 474.0 COG0086@1|root,COG0086@2|Bacteria,1MU3M@1224|Proteobacteria,1RPYH@1236|Gammaproteobacteria,1WVVI@135613|Chromatiales 135613|Chromatiales K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoC - 2.7.7.6 ko:K03046 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5 k59_1462621_1 555793.WSK_2931 1.3e-42 158.0 COG4206@1|root,COG4206@2|Bacteria,1MXFM@1224|Proteobacteria,2TWYV@28211|Alphaproteobacteria,2K14T@204457|Sphingomonadales 204457|Sphingomonadales H Outer membrane receptor proteins, mostly Fe transport - - - - - - - - - - - - Plug,TonB_dep_Rec k59_1581469_1 1158762.KB898045_gene450 8.56e-21 91.3 COG4970@1|root,COG4970@2|Bacteria,1N7RS@1224|Proteobacteria,1SCFB@1236|Gammaproteobacteria,1WYQF@135613|Chromatiales 135613|Chromatiales NU Type II transport protein GspH - - - ko:K08084 - - - - ko00000,ko02044 3.A.15.2 - - GspH,N_methyl k59_556685_1 1027273.GZ77_06500 2.21e-77 236.0 COG0259@1|root,COG0259@2|Bacteria,1NZUU@1224|Proteobacteria,1RMQ2@1236|Gammaproteobacteria,1XJ87@135619|Oceanospirillales 135619|Oceanospirillales H Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) pdxH - 1.4.3.5 ko:K00275 ko00750,ko01100,ko01120,map00750,map01100,map01120 M00124 R00277,R00278,R01710,R01711 RC00048,RC00116 ko00000,ko00001,ko00002,ko01000 - - - PNP_phzG_C,Putative_PNPOx k59_1009122_2 948071.S4S2D9_9CAUD 2.29e-122 372.0 4QAXQ@10239|Viruses,4QUSY@35237|dsDNA viruses no RNA stage,4QRFY@28883|Caudovirales,4QNQ6@10744|Podoviridae 10744|Podoviridae S ribonucleoside-triphosphate reductase activity - - - - - - - - - - - - - k59_1523950_1 1175306.GWL_26700 5.77e-39 138.0 COG2267@1|root,COG2267@2|Bacteria,1QTAP@1224|Proteobacteria,2VMEV@28216|Betaproteobacteria,47249@75682|Oxalobacteraceae 28216|Betaproteobacteria I Serine aminopeptidase, S33 - - - - - - - - - - - - Abhydrolase_1,Abhydrolase_6 k59_908135_1 926550.CLDAP_05310 1.8e-33 127.0 COG1319@1|root,COG1319@2|Bacteria,2G8QC@200795|Chloroflexi 200795|Chloroflexi C CO dehydrogenase flavoprotein C-terminal domain - - - - - - - - - - - - CO_deh_flav_C,FAD_binding_5 k59_1021719_1 1205680.CAKO01000029_gene5159 6.93e-65 209.0 COG2141@1|root,COG2141@2|Bacteria,1MX64@1224|Proteobacteria,2TV8M@28211|Alphaproteobacteria,2JXBR@204441|Rhodospirillales 204441|Rhodospirillales C Luciferase-like monooxygenase - - - - - - - - - - - - Bac_luciferase k59_795489_1 566466.NOR53_533 1.37e-36 142.0 COG0308@1|root,COG0308@2|Bacteria,1MUCI@1224|Proteobacteria,1RYP9@1236|Gammaproteobacteria,1J606@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Peptidase family M1 domain - - - - - - - - - - - - Peptidase_M1 k59_287184_1 646529.Desaci_2447 7.92e-06 50.4 COG0079@1|root,COG0079@2|Bacteria,1TP5D@1239|Firmicutes,248Q0@186801|Clostridia,260RS@186807|Peptococcaceae 186801|Clostridia E PFAM Aminotransferase class I and II - - 4.1.1.81 ko:K04720 ko00860,map00860 - R06530 RC00517 ko00000,ko00001,ko01000 - - - Aminotran_1_2 k59_287184_2 1385521.N803_17460 3.25e-43 154.0 COG1270@1|root,COG1270@2|Bacteria,2GMB8@201174|Actinobacteria,4FEC6@85021|Intrasporangiaceae 201174|Actinobacteria H Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group cobD - 6.3.1.10 ko:K02227 ko00860,ko01100,map00860,map01100 M00122 R06529,R07302 RC00090,RC00096 ko00000,ko00001,ko00002,ko01000 - - - CobD_Cbib k59_964789_1 459349.CLOAM1207 3.16e-86 271.0 COG0008@1|root,COG0008@2|Bacteria,2NNRW@2323|unclassified Bacteria 2|Bacteria J tRNA synthetases class I (E and Q), anti-codon binding domain glnS GO:0003674,GO:0003824,GO:0004812,GO:0004819,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006425,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.18 ko:K01886 ko00970,ko01100,map00970,map01100 M00359,M00360 R03652 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iECIAI39_1322.ECIAI39_0637 tRNA-synt_1c,tRNA-synt_1c_C k59_1473285_1 1121033.AUCF01000018_gene5781 5.73e-23 97.8 COG0500@1|root,COG0640@1|root,COG0640@2|Bacteria,COG2226@2|Bacteria,1NFSV@1224|Proteobacteria,2TSMV@28211|Alphaproteobacteria,2JPME@204441|Rhodospirillales 204441|Rhodospirillales KQ helix_turn_helix, Arsenical Resistance Operon Repressor - - - - - - - - - - - - HTH_20,HTH_5,Methyltransf_11 k59_1473285_2 187272.Mlg_0166 4.29e-34 128.0 COG0064@1|root,COG0064@2|Bacteria,1MUKG@1224|Proteobacteria,1RP7U@1236|Gammaproteobacteria,1WX4J@135613|Chromatiales 135613|Chromatiales J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) gatB - 6.3.5.6,6.3.5.7 ko:K02434 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - GatB_N,GatB_Yqey k59_399904_1 1122137.AQXF01000001_gene2897 2.07e-35 133.0 COG5330@1|root,COG5330@2|Bacteria,1R4CF@1224|Proteobacteria,2TYQC@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Uncharacterised protein conserved in bacteria (DUF2336) - - - - - - - - - - - - DUF2336 k59_343676_1 316407.85676807 5.73e-75 231.0 COG3700@1|root,COG3700@2|Bacteria,1PRRA@1224|Proteobacteria,1RP0N@1236|Gammaproteobacteria,3XMYK@561|Escherichia 1236|Gammaproteobacteria S Dephosphorylates several organic phosphate monoesters including 3'- and 5'-nucleotides, 2'-deoxy-5'-nucleotides, pNPP, phenyl phosphate, glycerol 2-phosphate, ribose 5-phosphate, O- phospho-L-amino acids and phytic acid, showing the highest activity with aryl phosphoesters (pNPP, phenyl phosphate and O- phospho-L-tyrosine), and to a lesser extent with 3'- and 5'- nucleotides. No activity toward ATP, phosphodiesters, glycerol-1- phosphate, glucose 1-phosphate, glucose 6-phosphate, NADP, GTP or 3',5'-cAMP, ADP or ATP. Also has a phosphotransferase activity catalyzing the transfer of low-energy phosphate groups from organic phosphate monoesters to free hydroxyl groups of various organic compounds. Capable of transferring phosphate from either pNPP or UMP to adenosine or uridine. Does not exhibit nucleotide phosphomutase activity aphA GO:0003674,GO:0003824,GO:0003993,GO:0004647,GO:0005488,GO:0005575,GO:0005623,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0030288,GO:0030313,GO:0031975,GO:0042578,GO:0042597,GO:0044237,GO:0044464,GO:0048037 3.1.3.2 ko:K03788 ko00740,ko01100,map00740,map01100 - R00548 RC00017 ko00000,ko00001,ko01000 - - iECIAI39_1322.ECIAI39_4476,iYL1228.KPN_04442 Acid_phosphat_B k59_1473290_1 76869.PputGB1_5283 2.32e-31 124.0 COG3072@1|root,COG3072@2|Bacteria,1PI5T@1224|Proteobacteria,1RMPZ@1236|Gammaproteobacteria,1YUXN@136845|Pseudomonas putida group 1236|Gammaproteobacteria F Adenylate cyclase cyaA GO:0003674,GO:0003824,GO:0004016,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006171,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009187,GO:0009190,GO:0009259,GO:0009260,GO:0009975,GO:0009987,GO:0016829,GO:0016849,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046058,GO:0046390,GO:0046483,GO:0052652,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.6.1.1 ko:K05851 ko00230,ko02026,ko05111,map00230,map02026,map05111 - R00089,R00434 RC00295 ko00000,ko00001,ko01000 - - iAPECO1_1312.APECO1_2672,iECOK1_1307.ECOK1_4253,iECS88_1305.ECS88_4229,iUMN146_1321.UM146_19155,iUTI89_1310.UTI89_C4365 Adenyl_cycl_N,Adenylate_cycl k59_61207_1 1123400.KB904749_gene770 1.56e-94 285.0 COG3000@1|root,COG3000@2|Bacteria,1NR7X@1224|Proteobacteria,1RQDX@1236|Gammaproteobacteria 1236|Gammaproteobacteria I sterol desaturase erg - - - - - - - - - - - FA_hydroxylase k59_1755633_1 436308.Nmar_0111 3.73e-19 81.6 COG0432@1|root,arCOG04214@2157|Archaea,41T31@651137|Thaumarchaeota 651137|Thaumarchaeota S Uncharacterised protein family UPF0047 - - - - - - - - - - - - UPF0047 k59_1755633_2 1229909.NSED_00250 7.38e-29 106.0 arCOG08723@1|root,arCOG08723@2157|Archaea,41SPX@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_569394_1 1267535.KB906767_gene2550 1.38e-69 229.0 COG0449@1|root,COG0449@2|Bacteria,3Y2NE@57723|Acidobacteria,2JI69@204432|Acidobacteriia 204432|Acidobacteriia M Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source glmS - 2.6.1.16 ko:K00820 ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931 - R00768 RC00010,RC00163,RC02752 ko00000,ko00001,ko01000,ko01002 - - - GATase_6,SIS k59_908154_1 62928.azo0716 1.07e-52 189.0 COG1643@1|root,COG1643@2|Bacteria,1MUEQ@1224|Proteobacteria,2VI3R@28216|Betaproteobacteria,2KUB1@206389|Rhodocyclales 206389|Rhodocyclales L Helicase associated domain (HA2) Add an annotation hrpA - 3.6.4.13 ko:K03578 - - - - ko00000,ko01000 - - - DEAD,DUF3418,HA2,Helicase_C,OB_NTP_bind k59_61214_1 1122137.AQXF01000005_gene1107 1.61e-118 346.0 COG5285@1|root,COG5285@2|Bacteria,1Q78R@1224|Proteobacteria,2TSX3@28211|Alphaproteobacteria 28211|Alphaproteobacteria Q Phytanoyl-CoA dioxygenase (PhyH) - - - - - - - - - - - - PhyH k59_795494_1 1122194.AUHU01000014_gene1168 9.47e-84 258.0 COG0337@1|root,COG0337@2|Bacteria,1MUBK@1224|Proteobacteria,1RN4I@1236|Gammaproteobacteria,46412@72275|Alteromonadaceae 1236|Gammaproteobacteria E Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) aroB GO:0000166,GO:0003674,GO:0003824,GO:0003856,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016838,GO:0019438,GO:0019752,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046417,GO:0046872,GO:0046914,GO:0048037,GO:0050662,GO:0051287,GO:0070403,GO:0071704,GO:0097159,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 4.2.3.4 ko:K01735 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R03083 RC00847 ko00000,ko00001,ko00002,ko01000 - - iAF1260.b3389,iBWG_1329.BWG_3080,iECDH10B_1368.ECDH10B_3564,iECDH1ME8569_1439.ECDH1ME8569_3268,iECNA114_1301.ECNA114_3486,iEcDH1_1363.EcDH1_0324,iJO1366.b3389,iJR904.b3389,iY75_1357.Y75_RS20275 DHQ_synthase k59_625763_1 1168065.DOK_01029 2.67e-81 256.0 COG0119@1|root,COG0119@2|Bacteria,1MUNQ@1224|Proteobacteria,1RMWE@1236|Gammaproteobacteria,1J4FM@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) leuA GO:0003674,GO:0003824,GO:0003852,GO:0003985,GO:0003988,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009987,GO:0016053,GO:0016407,GO:0016408,GO:0016453,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046912,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.3.3.13 ko:K01649 ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230 M00432 R01213 RC00004,RC00470,RC02754 br01601,ko00000,ko00001,ko00002,ko01000 - - iSFV_1184.SFV_0066 HMGL-like,LeuA_dimer k59_739236_1 1117647.M5M_12465 4.4e-12 61.6 COG0759@1|root,COG0759@2|Bacteria,1N6U4@1224|Proteobacteria,1SCG6@1236|Gammaproteobacteria,1J6YU@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Could be involved in insertion of integral membrane proteins into the membrane yidD GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0008565,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0016043,GO:0031224,GO:0031226,GO:0032977,GO:0033036,GO:0034613,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0061024,GO:0070727,GO:0071702,GO:0071705,GO:0071840,GO:0071944,GO:0072657,GO:0090150 - ko:K08998 - - - - ko00000 - - - Haemolytic k59_739236_2 247634.GPB2148_371 1.12e-42 143.0 COG0594@1|root,COG0594@2|Bacteria,1MZQE@1224|Proteobacteria,1S90M@1236|Gammaproteobacteria,1J74P@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme rnpA GO:0000966,GO:0001682,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004526,GO:0004540,GO:0004549,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005655,GO:0005730,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0030677,GO:0030681,GO:0031974,GO:0031981,GO:0032991,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0044237,GO:0044238,GO:0044422,GO:0044424,GO:0044428,GO:0044446,GO:0044452,GO:0044464,GO:0046483,GO:0070013,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0099116,GO:0140098,GO:0140101,GO:1901360,GO:1902494,GO:1902555,GO:1905348,GO:1990904 3.1.26.5 ko:K03536 - - - - ko00000,ko01000,ko03016 - - - Ribonuclease_P k59_1247353_1 1122137.AQXF01000001_gene2963 7.81e-130 392.0 COG0642@1|root,COG2205@2|Bacteria,1MVY8@1224|Proteobacteria,2TS5B@28211|Alphaproteobacteria 28211|Alphaproteobacteria T Histidine kinase divL GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - - - - - - - - - - HATPase_c,HisKA,PAS_7,PAS_8 k59_851922_1 158500.BV97_02683 2.4e-87 278.0 COG4206@1|root,COG4206@2|Bacteria,1R1WX@1224|Proteobacteria,2U0GK@28211|Alphaproteobacteria,2K1DC@204457|Sphingomonadales 204457|Sphingomonadales H receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_964813_1 450851.PHZ_c1807 1.42e-81 261.0 COG2072@1|root,COG2072@2|Bacteria,1MUQH@1224|Proteobacteria,2TRG4@28211|Alphaproteobacteria,2KIUB@204458|Caulobacterales 204458|Caulobacterales C Flavin-binding monooxygenase-like - - 1.14.13.84 ko:K14520 ko00363,ko01100,ko01120,map00363,map01100,map01120 - R06892 RC01644 ko00000,ko00001,ko01000 - - - - k59_795509_1 1260251.SPISAL_07510 2.17e-71 241.0 COG0085@1|root,COG0085@2|Bacteria,1MUC4@1224|Proteobacteria,1RMK0@1236|Gammaproteobacteria,1WX4P@135613|Chromatiales 135613|Chromatiales K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoB - 2.7.7.6 ko:K03043 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7 k59_739243_2 1122137.AQXF01000003_gene2033 4.82e-62 209.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,2TQR7@28211|Alphaproteobacteria 28211|Alphaproteobacteria T methyl-accepting chemotaxis protein - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - MCPsignal,PAS_3,PAS_4,PAS_9 k59_1360331_1 685727.REQ_07970 8.16e-16 82.4 COG2515@1|root,COG2515@2|Bacteria,2GIV5@201174|Actinobacteria,4FZDF@85025|Nocardiaceae 201174|Actinobacteria E Pyridoxal-phosphate dependent enzyme - - 4.4.1.15 ko:K05396 ko00270,map00270 - R01874 RC00382 ko00000,ko00001,ko01000 - - - PALP k59_1360331_2 1268635.Loa_01511 2.03e-08 59.3 COG1376@1|root,COG1376@2|Bacteria,1MVYT@1224|Proteobacteria,1RMNC@1236|Gammaproteobacteria,1JD0Y@118969|Legionellales 118969|Legionellales M L,D-transpeptidase catalytic domain - - - ko:K16291 - - - - ko00000,ko01002,ko01011 - - - YkuD k59_1699253_2 349520.PPE_02017 3.18e-32 122.0 COG0673@1|root,COG0673@2|Bacteria,1TPT5@1239|Firmicutes,4HAPJ@91061|Bacilli,26TP1@186822|Paenibacillaceae 91061|Bacilli S Oxidoreductase - - - - - - - - - - - - GFO_IDH_MocA,GFO_IDH_MocA_C k59_1642828_1 1229909.NSED_07230 6.27e-12 63.5 arCOG08805@1|root,arCOG08805@2157|Archaea,41T3X@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1642828_2 1229909.NSED_07225 2e-39 135.0 COG0517@1|root,arCOG00606@2157|Archaea 2157|Archaea I CBS domain - - - - - - - - - - - - CBS k59_61242_1 1122137.AQXF01000003_gene1962 1.15e-108 322.0 COG3540@1|root,COG3540@2|Bacteria,1R5RU@1224|Proteobacteria,2U4KZ@28211|Alphaproteobacteria 28211|Alphaproteobacteria P COG3540 Phosphodiesterase alkaline phosphatase D - - 3.1.3.1 ko:K01113 ko00790,ko01100,ko02020,map00790,map01100,map02020 M00126 R04620 RC00017 ko00000,ko00001,ko00002,ko01000 - - - PhoD k59_1360336_1 1260251.SPISAL_03200 4.14e-98 305.0 COG1185@1|root,COG1185@2|Bacteria,1MVB9@1224|Proteobacteria,1RNBF@1236|Gammaproteobacteria,1WW27@135613|Chromatiales 135613|Chromatiales J Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction pnp - 2.7.7.8 ko:K00962 ko00230,ko00240,ko03018,map00230,map00240,map03018 M00394 R00437,R00438,R00439,R00440 RC02795 ko00000,ko00001,ko00002,ko01000,ko03016,ko03019 - - - KH_1,PNPase,RNase_PH,RNase_PH_C,S1 k59_1642831_1 265072.Mfla_2758 2.6e-64 211.0 COG0706@1|root,COG0706@2|Bacteria,1MV5M@1224|Proteobacteria,2VHIA@28216|Betaproteobacteria,2KM2S@206350|Nitrosomonadales 206350|Nitrosomonadales U Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins yidC - - ko:K03217 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044,ko03029 2.A.9 - - 60KD_IMP,YidC_periplas k59_287248_1 1232683.ADIMK_1047 2.29e-38 145.0 COG2199@1|root,COG3706@2|Bacteria,1MWHH@1224|Proteobacteria,1RRU7@1236|Gammaproteobacteria,465TD@72275|Alteromonadaceae 1236|Gammaproteobacteria T 7TMR-DISM extracellular 2 - - - - - - - - - - - - 7TMR-DISMED2,7TMR-DISM_7TM,GGDEF k59_1247372_1 743719.PaelaDRAFT_6016 8.35e-07 57.8 COG2385@1|root,COG2385@2|Bacteria,1UW6J@1239|Firmicutes,4HCNK@91061|Bacilli,26SG4@186822|Paenibacillaceae 91061|Bacilli D sporulation protein - - - ko:K06381 - - - - ko00000 - - - SPOR,SpoIID k59_1642838_1 402626.Rpic_0864 1.32e-46 158.0 COG0714@1|root,COG0714@2|Bacteria,1MV5I@1224|Proteobacteria,2VH9H@28216|Betaproteobacteria,1K2UE@119060|Burkholderiaceae 28216|Betaproteobacteria S ATPase associated with various cellular activities, AAA_5 - - - - - - - - - - - - AAA,AAA_5 k59_1642838_2 1033802.SSPSH_001193 1.23e-17 82.0 COG3825@1|root,COG3825@2|Bacteria,1MUAJ@1224|Proteobacteria,1RMRY@1236|Gammaproteobacteria 1236|Gammaproteobacteria S protein conserved in bacteria IV02_28405 - - ko:K09989 - - - - ko00000 - - - VWA_CoxE k59_1021794_1 261292.Nit79A3_2077 1.87e-39 149.0 COG0532@1|root,COG0532@2|Bacteria,1MV26@1224|Proteobacteria,2VK2H@28216|Betaproteobacteria,37258@32003|Nitrosomonadales 28216|Betaproteobacteria J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex infB - - ko:K02519 - - - - ko00000,ko03012,ko03029 - - - GTP_EFTU,IF-2,IF2_N,IF2_assoc k59_1021794_2 1288494.EBAPG3_22420 6.68e-10 59.3 COG0195@1|root,COG0195@2|Bacteria,1MWT7@1224|Proteobacteria,2VH2X@28216|Betaproteobacteria,372CV@32003|Nitrosomonadales 28216|Betaproteobacteria K Participates in both transcription termination and antitermination nusA - - ko:K02600 - - - - ko00000,ko03009,ko03021 - - - HHH_5,KH_5,NusA_N,S1 k59_1416629_1 909663.KI867151_gene3159 0.000121 49.7 COG2202@1|root,COG4191@1|root,COG4585@1|root,COG5001@1|root,COG2202@2|Bacteria,COG4191@2|Bacteria,COG4585@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria 1224|Proteobacteria T Diguanylate cyclase - - 2.7.7.65 ko:K21084 ko02026,map02026 - - - ko00000,ko00001,ko01000 - - - CHASE,GAF,GAF_2,GGDEF,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_8,PAS_9,SBP_bac_3,dCache_1 k59_61265_1 797114.C475_00295 5.4e-07 56.2 28I5K@1|root,2N5U5@2157|Archaea,2XX25@28890|Euryarchaeota,23VXZ@183963|Halobacteria 183963|Halobacteria - - - - - - - - - - - - - - - k59_1190965_1 1144305.PMI02_03612 4.3e-86 281.0 COG1520@1|root,COG1520@2|Bacteria,1P31B@1224|Proteobacteria,2U4EC@28211|Alphaproteobacteria,2K25M@204457|Sphingomonadales 204457|Sphingomonadales S Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane - - - - - - - - - - - - - k59_1134386_1 392499.Swit_0710 5.67e-12 70.9 COG2271@1|root,COG2271@2|Bacteria,1MWYR@1224|Proteobacteria,2U1SE@28211|Alphaproteobacteria 28211|Alphaproteobacteria G Major facilitator Superfamily - - - - - - - - - - - - MFS_1 k59_1134386_2 1460634.JCM19037_2406 4.3e-53 181.0 COG0657@1|root,COG0657@2|Bacteria,1TRYT@1239|Firmicutes,4HC3I@91061|Bacilli 91061|Bacilli I esterase lipase lipP - - ko:K01066 - - - - ko00000,ko01000 - - - Abhydrolase_3 k59_740230_1 1278073.MYSTI_02057 2.8e-41 159.0 COG0318@1|root,COG3319@1|root,COG0318@2|Bacteria,COG3319@2|Bacteria,1MU6G@1224|Proteobacteria 1224|Proteobacteria IQ COG0318, Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II - - - - - - - - - - - - AMP-binding,AMP-binding_C,Bac_luciferase,Condensation,KR,Ketoacyl-synt_C,PP-binding,Thioesterase,ketoacyl-synt k59_1078736_1 519989.ECTPHS_06532 3.43e-126 372.0 COG0533@1|root,COG0533@2|Bacteria,1MU6S@1224|Proteobacteria,1RN8M@1236|Gammaproteobacteria,1WWRX@135613|Chromatiales 135613|Chromatiales O Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction tsaD - 2.3.1.234 ko:K01409 - - R10648 RC00070,RC00416 ko00000,ko01000,ko03016 - - - Peptidase_M22 k59_1474414_1 436308.Nmar_1300 3.7e-43 144.0 COG0589@1|root,arCOG02053@2157|Archaea 2157|Archaea T COG0589 Universal stress protein UspA and related nucleotide-binding proteins - - 2.7.13.3 ko:K07646 ko02020,map02020 M00454 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - DUF4118,GAF_3,KdpD,Usp k59_1192014_1 1121935.AQXX01000144_gene4379 3.62e-76 255.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1XHXU@135619|Oceanospirillales 135619|Oceanospirillales V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - - - - - - - - - - ACR_tran k59_1192014_2 247639.MGP2080_02056 2.46e-05 46.6 COG0845@1|root,COG0845@2|Bacteria,1R4JA@1224|Proteobacteria,1RPS5@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - - - - - - - - - - Biotin_lipoyl_2,HlyD_3,HlyD_D23 k59_1417638_1 1288494.EBAPG3_22420 7.92e-80 252.0 COG0195@1|root,COG0195@2|Bacteria,1MWT7@1224|Proteobacteria,2VH2X@28216|Betaproteobacteria,372CV@32003|Nitrosomonadales 28216|Betaproteobacteria K Participates in both transcription termination and antitermination nusA - - ko:K02600 - - - - ko00000,ko03009,ko03021 - - - HHH_5,KH_5,NusA_N,S1 k59_457515_1 1469245.JFBG01000065_gene115 4.05e-74 238.0 COG0651@1|root,COG0651@2|Bacteria,1QU5Z@1224|Proteobacteria,1T20X@1236|Gammaproteobacteria,1X2NN@135613|Chromatiales 135613|Chromatiales CP Proton-conducting membrane transporter - - - ko:K05568 - - - - ko00000,ko02000 2.A.63.1,2.A.63.2 - - Proton_antipo_M,Proton_antipo_N k59_344766_1 203119.Cthe_0917 2.17e-81 260.0 COG0008@1|root,COG0008@2|Bacteria,1TP8G@1239|Firmicutes,247Y0@186801|Clostridia,3WH6G@541000|Ruminococcaceae 186801|Clostridia J glutaminyl-tRNA synthetase glnS - 6.1.1.18 ko:K01886 ko00970,ko01100,map00970,map01100 M00359,M00360 R03652 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_1c,tRNA-synt_1c_C k59_344766_2 356829.BITS_0186 1.4e-32 134.0 COG0436@1|root,COG0436@2|Bacteria,2GJ7R@201174|Actinobacteria,4CZFY@85004|Bifidobacteriales 201174|Actinobacteria E DegT/DnrJ/EryC1/StrS aminotransferase family aspC - 2.6.1.1 ko:K00812 ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230 - R00355,R00694,R00734,R00896,R02433,R02619,R05052 RC00006 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_1_2 k59_400971_1 1121933.AUHH01000024_gene2921 4.22e-27 106.0 COG4315@1|root,COG4315@2|Bacteria,2GNDV@201174|Actinobacteria 201174|Actinobacteria S Secreted repeat of unknown function - - - - - - - - - - - - Lipoprotein_15 k59_1417654_1 935848.JAEN01000006_gene3097 1.83e-32 127.0 COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,2TTWX@28211|Alphaproteobacteria,2PV7W@265|Paracoccus 28211|Alphaproteobacteria E DegT/DnrJ/EryC1/StrS aminotransferase family aatB - 2.6.1.1 ko:K00812 ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230 - R00355,R00694,R00734,R00896,R02433,R02619,R05052 RC00006 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_1_2 k59_5603_1 401053.AciPR4_2074 4.64e-13 73.9 COG1306@1|root,COG1306@2|Bacteria,3Y791@57723|Acidobacteria,2JKV4@204432|Acidobacteriia 204432|Acidobacteriia S Putative glycosyl hydrolase domain - - - - - - - - - - - - DUF4015 k59_400975_1 243233.MCA0211 1.49e-30 112.0 2D4GA@1|root,32TH1@2|Bacteria,1N4D6@1224|Proteobacteria,1TI4M@1236|Gammaproteobacteria,1XGHI@135618|Methylococcales 135618|Methylococcales S Protein of unknown function (DUF3024) - - - - - - - - - - - - DUF3024 k59_400975_2 1207063.P24_00835 5.53e-13 69.3 COG1104@1|root,COG1104@2|Bacteria,1MU1C@1224|Proteobacteria,2TSQE@28211|Alphaproteobacteria,2JPMZ@204441|Rhodospirillales 204441|Rhodospirillales E COG1104 Cysteine sulfinate desulfinase cysteine desulfurase and related enzymes nifS - 2.8.1.7 ko:K04487 ko00730,ko01100,ko04122,map00730,map01100,map04122 - R07460,R11528,R11529 RC01789,RC02313 ko00000,ko00001,ko01000,ko02048,ko03016,ko03029 - - - Aminotran_5 k59_1756720_1 1100721.ALKO01000008_gene2653 2.22e-37 134.0 COG0625@1|root,COG0625@2|Bacteria,1RAP2@1224|Proteobacteria,2VQGV@28216|Betaproteobacteria,4AD2P@80864|Comamonadaceae 28216|Betaproteobacteria O Glutathione S-transferase - - 2.5.1.18 ko:K00799 ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418 - R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905 RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944 ko00000,ko00001,ko01000,ko02000 1.A.12.2.2,1.A.12.3.2 - - GST_C_2,GST_N_3 k59_1756720_2 399795.CtesDRAFT_PD1953 1.6e-73 233.0 COG1028@1|root,COG1028@2|Bacteria,1QU4S@1224|Proteobacteria,2VH03@28216|Betaproteobacteria,4ABN7@80864|Comamonadaceae 28216|Betaproteobacteria IQ Belongs to the short-chain dehydrogenases reductases (SDR) family - - - - - - - - - - - - adh_short k59_683293_1 998674.ATTE01000001_gene2894 1.27e-50 173.0 COG0687@1|root,COG0687@2|Bacteria,1MU0I@1224|Proteobacteria,1RMY4@1236|Gammaproteobacteria 1236|Gammaproteobacteria E Spermidine putrescine-binding periplasmic protein - - - ko:K02055 ko02024,map02024 M00193 - - ko00000,ko00001,ko00002,ko02000 3.A.1.11 - - SBP_bac_8 k59_1248382_1 1255043.TVNIR_2779 9.76e-54 187.0 COG0323@1|root,COG0323@2|Bacteria,1MV61@1224|Proteobacteria,1RM89@1236|Gammaproteobacteria,1WWKZ@135613|Chromatiales 135613|Chromatiales L This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex mutL - - ko:K03572 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - DNA_mis_repair,HATPase_c_3,MutL_C k59_513759_1 1459636.NTE_00589 5.45e-18 88.6 COG0726@1|root,arCOG09729@1|root,arCOG02876@2157|Archaea,arCOG09729@2157|Archaea,41T20@651137|Thaumarchaeota 2157|Archaea G xylanase chitin deacetylase - - 3.5.1.104 ko:K22278 - - - - ko00000,ko01000 - - - CHB_HEX_C_1,HYR,Polysacc_deac_1 k59_1192044_1 1229909.NSED_00170 2.21e-172 488.0 COG0677@1|root,arCOG00252@2157|Archaea,41S8F@651137|Thaumarchaeota 651137|Thaumarchaeota M Belongs to the UDP-glucose GDP-mannose dehydrogenase family - - - - - - - - - - - - - k59_1474460_1 436308.Nmar_1035 5.76e-10 59.3 COG1980@1|root,arCOG04180@2157|Archaea,41S67@651137|Thaumarchaeota 651137|Thaumarchaeota G Catalyzes two subsequent steps in gluconeogenesis the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P) fbp - 3.1.3.11,4.1.2.13 ko:K01622 ko00010,ko00030,ko00051,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map01100,map01110,map01120,map01130,map01200,map01230 M00003 R00762,R01068,R01070,R02568,R04780 RC00017,RC00438,RC00439 ko00000,ko00001,ko00002,ko01000 - - - FBPase_3 k59_1474460_2 436308.Nmar_1036 2.39e-68 209.0 arCOG08725@1|root,arCOG08725@2157|Archaea,41T3W@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_626904_1 1121035.AUCH01000019_gene2896 2.97e-18 79.0 2EB0P@1|root,330T4@2|Bacteria,1QAEY@1224|Proteobacteria,2VWEP@28216|Betaproteobacteria,2M035@206389|Rhodocyclales 206389|Rhodocyclales - - - - - - - - - - - - - - - k59_626904_2 85643.Tmz1t_1768 8.9e-09 55.8 COG0172@1|root,COG0172@2|Bacteria,1MUJF@1224|Proteobacteria,2VHJJ@28216|Betaproteobacteria,2KV4N@206389|Rhodocyclales 206389|Rhodocyclales J Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) serS - 6.1.1.11 ko:K01875 ko00970,map00970 M00359,M00360 R03662,R08218 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Seryl_tRNA_N,tRNA-synt_2b k59_1644044_1 391587.KAOT1_01929 2.6e-97 295.0 COG0114@1|root,COG0114@2|Bacteria,4NEQP@976|Bacteroidetes,1HX3F@117743|Flavobacteriia 976|Bacteroidetes C Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate fumC - 4.2.1.2 ko:K01679 ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04934,ko05200,ko05211,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200,map04934,map05200,map05211 M00009,M00011,M00173,M00376 R01082 RC00443 ko00000,ko00001,ko00002,ko01000 - - - FumaraseC_C,Lyase_1 k59_1530883_4 981369.JQMJ01000004_gene2721 6.68e-26 102.0 COG1024@1|root,COG1024@2|Bacteria,2GJ63@201174|Actinobacteria,2NFQV@228398|Streptacidiphilus 201174|Actinobacteria I Enoyl-CoA hydratase/isomerase echA5 - 4.2.1.17 ko:K01692 ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212 M00032,M00087 R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093 RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 - - - ECH_1 k59_118706_1 237727.NAP1_02195 5.12e-88 271.0 COG1520@1|root,COG1520@2|Bacteria,1MXIJ@1224|Proteobacteria,2TUAD@28211|Alphaproteobacteria,2K0GW@204457|Sphingomonadales 204457|Sphingomonadales S Pyrrolo-quinoline quinone - - - - - - - - - - - - PQQ_2,PQQ_3 k59_740276_1 932213.SPM24T3_19555 1.85e-92 283.0 COG0617@1|root,COG0617@2|Bacteria,1MU2X@1224|Proteobacteria,1RPFJ@1236|Gammaproteobacteria,401B0@613|Serratia 1236|Gammaproteobacteria F Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. Also shows phosphatase, 2'- nucleotidase and 2',3'-cyclic phosphodiesterase activities. These phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases cca GO:0001680,GO:0003674,GO:0003824,GO:0004652,GO:0004810,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016437,GO:0016740,GO:0016772,GO:0016779,GO:0031123,GO:0034470,GO:0034641,GO:0034660,GO:0042245,GO:0042780,GO:0043170,GO:0043628,GO:0044237,GO:0044238,GO:0046483,GO:0070566,GO:0070567,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1990817 2.7.7.72 ko:K00974 ko03013,map03013 - R09382,R09383,R09384,R09386 RC00078 ko00000,ko00001,ko01000,ko03016 - - - HD,PolyA_pol,PolyA_pol_RNAbd k59_965838_2 1166948.JPZL01000001_gene2796 1.98e-18 87.0 COG3769@1|root,COG3769@2|Bacteria,1NFV5@1224|Proteobacteria,1RR9R@1236|Gammaproteobacteria,1XJXF@135619|Oceanospirillales 135619|Oceanospirillales S Mannosyl-3-phosphoglycerate phosphatase - - 3.1.3.70 ko:K07026 ko00051,map00051 - R05790 RC00017 ko00000,ko00001,ko01000 - - - Hydrolase_3,S6PP k59_1756753_1 1122137.AQXF01000001_gene2796 8.98e-107 323.0 COG2200@1|root,COG2200@2|Bacteria,1MU4F@1224|Proteobacteria,2TU9M@28211|Alphaproteobacteria 28211|Alphaproteobacteria T EAL domain MA20_05620 - - ko:K13593 ko04112,map04112 - - - ko00000,ko00001 - - - EAL k59_1192065_1 867845.KI911784_gene2251 3.87e-13 74.7 COG0285@1|root,COG0285@2|Bacteria,2G64M@200795|Chloroflexi,37568@32061|Chloroflexia 32061|Chloroflexia H PFAM cytoplasmic peptidoglycan synthetase domain protein - - 6.3.2.12,6.3.2.17 ko:K11754 ko00790,ko01100,map00790,map01100 M00126,M00841 R00942,R02237,R04241 RC00064,RC00090,RC00162 ko00000,ko00001,ko00002,ko01000 - - - Mur_ligase_C,Mur_ligase_M k59_740288_1 316274.Haur_4945 5.35e-70 232.0 COG0488@1|root,COG0488@2|Bacteria,2G5VD@200795|Chloroflexi,3752Q@32061|Chloroflexia 2|Bacteria S PFAM ABC transporter related yjjK - - ko:K06158 - - - - ko00000,ko03012 - - - ABC_tran,ABC_tran_CTD,ABC_tran_Xtn k59_804714_2 996637.SGM_3746 2.65e-41 145.0 COG2364@1|root,COG2364@2|Bacteria,2GKA1@201174|Actinobacteria 201174|Actinobacteria S membrane - - - - - - - - - - - - - k59_1199715_1 402881.Plav_0812 2.25e-37 145.0 COG4206@1|root,COG4206@2|Bacteria,1MW63@1224|Proteobacteria,2TT3G@28211|Alphaproteobacteria,1JN86@119043|Rhodobiaceae 28211|Alphaproteobacteria H TonB-dependent Receptor Plug Domain - - - ko:K16092 - - - - ko00000,ko02000 1.B.14.3 - - Plug,TonB_dep_Rec k59_238977_1 1122137.AQXF01000002_gene91 1.94e-55 179.0 COG1127@1|root,COG1127@2|Bacteria,1MUSD@1224|Proteobacteria,2TR2I@28211|Alphaproteobacteria 28211|Alphaproteobacteria Q ABC transporter mkl - - ko:K02065 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - ABC_tran k59_238977_2 314285.KT71_01440 2.52e-17 82.8 COG1066@1|root,COG1066@2|Bacteria,1MUJQ@1224|Proteobacteria,1RN2E@1236|Gammaproteobacteria,1J989@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function radA GO:0000725,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009314,GO:0009628,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363 - ko:K04485 - - - - ko00000,ko03400 - - - AAA_25,ATPase,ChlI k59_1483087_1 331869.BAL199_03609 3.7e-58 206.0 COG0642@1|root,COG0784@1|root,COG4251@1|root,COG0784@2|Bacteria,COG2205@2|Bacteria,COG4251@2|Bacteria,1NRP8@1224|Proteobacteria 1224|Proteobacteria T Histidine kinase rcsC GO:0000155,GO:0000160,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006970,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009628,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0023014,GO:0023052,GO:0033554,GO:0035556,GO:0036211,GO:0042710,GO:0043170,GO:0043412,GO:0044010,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0044764,GO:0046777,GO:0050789,GO:0050794,GO:0050896,GO:0051704,GO:0051716,GO:0065007,GO:0071214,GO:0071470,GO:0071704,GO:0071944,GO:0104004,GO:0140096,GO:1901564 2.7.13.3 ko:K07677 ko02020,ko02026,map02020,map02026 M00474 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA,Hpt,PAS_3,RcsC,Response_reg k59_352854_1 1229909.NSED_07600 2.32e-51 163.0 arCOG08704@1|root,arCOG08704@2157|Archaea,41STG@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_972831_1 395493.BegalDRAFT_2701 1.32e-16 86.3 COG1262@1|root,COG1262@2|Bacteria,1NQ5K@1224|Proteobacteria,1RQVK@1236|Gammaproteobacteria,463M5@72273|Thiotrichales 72273|Thiotrichales S PFAM Formylglycine-generating sulfatase enzyme - - - - - - - - - - - - FGE-sulfatase k59_1651998_1 394221.Mmar10_0178 4.28e-79 263.0 COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,2TRWM@28211|Alphaproteobacteria,43WSR@69657|Hyphomonadaceae 28211|Alphaproteobacteria P Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K07787 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.6.1.4 - - ACR_tran k59_917216_1 396595.TK90_1054 1.85e-33 128.0 COG0251@1|root,COG0251@2|Bacteria,1NQGP@1224|Proteobacteria,1S2VU@1236|Gammaproteobacteria,1WYNS@135613|Chromatiales 135613|Chromatiales J pteridine-dependent deoxygenase - - 4.1.3.40,4.1.3.45 ko:K18240 ko00130,ko00400,ko01100,ko01110,map00130,map00400,map01100,map01110 M00117 R01302,R10597 RC00491,RC02148,RC03212 ko00000,ko00001,ko00002,ko01000 - - - - k59_972841_1 323261.Noc_0261 2.7e-26 106.0 COG1282@1|root,COG1282@2|Bacteria,1MUP4@1224|Proteobacteria,1RMR4@1236|Gammaproteobacteria,1WW1T@135613|Chromatiales 135613|Chromatiales C The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane - - 1.6.1.2 ko:K00325 ko00760,ko01100,map00760,map01100 - R00112 RC00001 ko00000,ko00001,ko01000 - - - PNTB k59_972841_2 396588.Tgr7_0267 9.9e-51 166.0 COG1403@1|root,COG1403@2|Bacteria,1MWEQ@1224|Proteobacteria,1S2R0@1236|Gammaproteobacteria,1WWXG@135613|Chromatiales 135613|Chromatiales L PFAM HNH endonuclease - - - - - - - - - - - - HNH_5 k59_1086482_1 1137281.D778_02568 4.15e-100 302.0 COG0677@1|root,COG0677@2|Bacteria,4NDTW@976|Bacteroidetes,1HWYT@117743|Flavobacteriia 976|Bacteroidetes M Belongs to the UDP-glucose GDP-mannose dehydrogenase family - - 1.1.1.136 ko:K02474,ko:K13015 ko00520,map00520 - R00421,R06894 RC00291 ko00000,ko00001,ko01000,ko01005 - - - UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N k59_1256097_1 697282.Mettu_3267 4.67e-105 319.0 COG0119@1|root,COG0119@2|Bacteria,1R7YB@1224|Proteobacteria,1RQB8@1236|Gammaproteobacteria,1XEJD@135618|Methylococcales 135618|Methylococcales E Belongs to the alpha-IPM synthase homocitrate synthase family - - 2.3.1.182 ko:K09011 ko00290,ko00660,ko01100,ko01210,ko01230,map00290,map00660,map01100,map01210,map01230 M00535 R07399 RC00004,RC01205 br01601,ko00000,ko00001,ko00002,ko01000 - - - HMGL-like,LeuA_dimer k59_917218_1 710111.FraQA3DRAFT_5758 2e-11 67.0 COG0179@1|root,COG0179@2|Bacteria,2GN2G@201174|Actinobacteria,4ERX7@85013|Frankiales 201174|Actinobacteria Q PFAM fumarylacetoacetate (FAA) hydrolase - - - - - - - - - - - - DUF2437,FAA_hydrolase k59_917218_2 290512.Paes_0455 2.23e-12 68.2 COG0115@1|root,COG0147@1|root,COG0115@2|Bacteria,COG0147@2|Bacteria,1FDGK@1090|Chlorobi 1090|Chlorobi EH TIGRFAM para-aminobenzoate synthase, subunit I - - 2.6.1.85,4.1.3.38 ko:K03342 ko00790,map00790 - R01716,R05553 RC00010,RC01418,RC01843,RC02148 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_4,Chorismate_bind k59_1256100_1 1168065.DOK_02841 8.13e-67 213.0 COG1566@1|root,COG1566@2|Bacteria,1MU7I@1224|Proteobacteria,1RMAD@1236|Gammaproteobacteria,1J6MZ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria V COG1566 Multidrug resistance efflux pump emrA - - ko:K03543 - M00701 - - ko00000,ko00002,ko02000 8.A.1.1 - - Biotin_lipoyl_2,HlyD_3,HlyD_D23 k59_1256100_2 1168065.DOK_02836 1.09e-13 70.9 COG0477@1|root,COG2814@2|Bacteria,1MU1I@1224|Proteobacteria,1RNTG@1236|Gammaproteobacteria,1J5ZS@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P the major facilitator superfamily emrB - - ko:K03446 - M00701 - - ko00000,ko00002,ko02000 2.A.1.3 - - MFS_1 k59_1483120_1 1396858.Q666_16370 5.16e-106 318.0 COG0141@1|root,COG0141@2|Bacteria,1MUUF@1224|Proteobacteria,1RMZD@1236|Gammaproteobacteria,463YJ@72275|Alteromonadaceae 1236|Gammaproteobacteria E Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine hisD - 1.1.1.23 ko:K00013 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R01158,R01163,R03012 RC00099,RC00242,RC00463 ko00000,ko00001,ko00002,ko01000 - - - Histidinol_dh k59_1199750_1 1459636.NTE_01492 2.72e-31 131.0 COG0642@1|root,arCOG02358@2157|Archaea,41T5G@651137|Thaumarchaeota 651137|Thaumarchaeota T PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - HATPase_c,HisKA,dCache_1 k59_804734_1 519989.ECTPHS_12617 2.11e-119 363.0 COG0018@1|root,COG0018@2|Bacteria,1MU4J@1224|Proteobacteria,1RPRC@1236|Gammaproteobacteria,1WVYV@135613|Chromatiales 135613|Chromatiales J Arginyl-tRNA synthetase argS - 6.1.1.19 ko:K01887 ko00970,map00970 M00359,M00360 R03646 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d k59_972857_1 203122.Sde_1215 2.79e-87 285.0 COG1073@1|root,COG1073@2|Bacteria,1NVTC@1224|Proteobacteria,1RNXQ@1236|Gammaproteobacteria,464FA@72275|Alteromonadaceae 1236|Gammaproteobacteria S COG1073 Hydrolases of the alpha beta superfamily - - - - - - - - - - - - Lipase_bact_N k59_917228_1 936136.ARRT01000006_gene3011 6.55e-72 234.0 COG1032@1|root,COG1032@2|Bacteria,1MY2Y@1224|Proteobacteria,2TT2P@28211|Alphaproteobacteria,4B9EQ@82115|Rhizobiaceae 28211|Alphaproteobacteria C Elongator protein 3, MiaB family, Radical SAM - - - - - - - - - - - - Radical_SAM k59_1764648_1 1122225.AULQ01000002_gene757 3.3e-100 296.0 COG0491@1|root,COG0491@2|Bacteria,4NE98@976|Bacteroidetes,1HX48@117743|Flavobacteriia 976|Bacteroidetes S beta-lactamase - - - - - - - - - - - - Lactamase_B k59_861863_2 1192868.CAIU01000035_gene4307 1.44e-38 132.0 COG1695@1|root,COG1695@2|Bacteria,1PMEP@1224|Proteobacteria,2V018@28211|Alphaproteobacteria,43QT4@69277|Phyllobacteriaceae 28211|Alphaproteobacteria K Transcriptional regulator PadR-like family - - - - - - - - - - - - PadR k59_521842_1 395495.Lcho_0236 1.76e-17 88.2 COG0591@1|root,COG0642@1|root,COG0591@2|Bacteria,COG2205@2|Bacteria,1MUY7@1224|Proteobacteria,2VKRS@28216|Betaproteobacteria 28216|Betaproteobacteria T histidine kinase A domain protein - - - - - - - - - - - - HATPase_c,HisKA,PAS_7,Response_reg k59_14352_1 153948.NAL212_0214 2.48e-05 45.4 297W1@1|root,2ZV2M@2|Bacteria,1QN4J@1224|Proteobacteria,2W2YU@28216|Betaproteobacteria,3747U@32003|Nitrosomonadales 28216|Betaproteobacteria S Domain of unknown function (DUF4396) - - - - - - - - - - - - DUF4396 k59_14352_2 319003.Bra1253DRAFT_08478 4.84e-12 68.9 COG0596@1|root,COG0596@2|Bacteria,1R9VJ@1224|Proteobacteria 1224|Proteobacteria S Alpha beta hydrolase - - - - - - - - - - - - Abhydrolase_1,Abhydrolase_6 k59_691851_1 158500.BV97_05004 3.22e-315 877.0 COG0693@1|root,COG0753@1|root,COG0693@2|Bacteria,COG0753@2|Bacteria,1MUXZ@1224|Proteobacteria,2TSG9@28211|Alphaproteobacteria,2K1IE@204457|Sphingomonadales 204457|Sphingomonadales P Serves to protect cells from the toxic effects of hydrogen peroxide - - 1.11.1.6 ko:K03781 ko00380,ko00630,ko01110,ko01130,ko01200,ko04011,ko04016,ko04068,ko04146,ko04211,ko04212,ko04213,ko05014,map00380,map00630,map01110,map01130,map01200,map04011,map04016,map04068,map04146,map04211,map04212,map04213,map05014 M00532 R00009,R00602,R02670 RC00034,RC00767,RC02141,RC02755 ko00000,ko00001,ko00002,ko01000 - - - Catalase,Catalase-rel k59_1483741_1 765910.MARPU_04925 0.000204 42.7 COG0233@1|root,COG0233@2|Bacteria,1N66T@1224|Proteobacteria,1RN75@1236|Gammaproteobacteria,1WY5S@135613|Chromatiales 135613|Chromatiales J Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another frr - - ko:K02838 - - - - ko00000,ko03012 - - - RRF k59_1483741_2 391615.ABSJ01000026_gene145 1.03e-113 332.0 COG0528@1|root,COG0528@2|Bacteria,1MV3N@1224|Proteobacteria,1RMHX@1236|Gammaproteobacteria,1J513@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria F Catalyzes the reversible phosphorylation of UMP to UDP pyrH - 2.7.4.22 ko:K09903 ko00240,ko01100,map00240,map01100 - R00158 RC00002 ko00000,ko00001,ko01000 - - - AA_kinase k59_1483741_3 2340.JV46_15060 0.000248 42.7 COG0264@1|root,COG0264@2|Bacteria,1MUS2@1224|Proteobacteria,1RPBJ@1236|Gammaproteobacteria,1J4Y4@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome tsf GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005085,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0019899,GO:0034641,GO:0034645,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0051020,GO:0065007,GO:0065009,GO:0071704,GO:0097159,GO:0098772,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - ko:K02357 - - - - ko00000,ko03012,ko03029 - - - EF_TS k59_239605_1 316407.85676206 2.93e-100 301.0 COG0006@1|root,COG0006@2|Bacteria,1MURT@1224|Proteobacteria,1RMKT@1236|Gammaproteobacteria,3XM9C@561|Escherichia 1236|Gammaproteobacteria E Splits dipeptides with a prolyl residue in the C- terminal position pepQ GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008235,GO:0008237,GO:0008238,GO:0009056,GO:0009987,GO:0016787,GO:0016805,GO:0019538,GO:0030145,GO:0034641,GO:0043167,GO:0043169,GO:0043170,GO:0043171,GO:0043603,GO:0044237,GO:0044238,GO:0044248,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0070011,GO:0070573,GO:0071704,GO:0140096,GO:1901564,GO:1901565,GO:1901575 3.4.13.9 ko:K01271 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M24 k59_239605_2 199310.c4795 2.57e-63 197.0 COG1739@1|root,COG1739@2|Bacteria,1NFJC@1224|Proteobacteria,1RPBF@1236|Gammaproteobacteria,3XNVA@561|Escherichia 1236|Gammaproteobacteria S Uncharacterized protein family UPF0029 yigZ - 2.1.1.45 ko:K00560 ko00240,ko00670,ko01100,ko01523,map00240,map00670,map01100,map01523 M00053 R02101 RC00219,RC00332 ko00000,ko00001,ko00002,ko01000 - - - DUF1949,UPF0029 k59_1708562_1 1379270.AUXF01000002_gene1290 1.45e-23 105.0 COG0515@1|root,COG0515@2|Bacteria,1ZUFG@142182|Gemmatimonadetes 142182|Gemmatimonadetes KLT Protein kinase domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase k59_1313931_1 1088721.NSU_3870 1.01e-48 158.0 28YKP@1|root,2ZKEE@2|Bacteria,1NBD7@1224|Proteobacteria,2UHHD@28211|Alphaproteobacteria,2K531@204457|Sphingomonadales 204457|Sphingomonadales S Pilus assembly protein PilZ - - - - - - - - - - - - PilZ k59_1313931_2 291985.CCSI01000001_gene2479 2.11e-19 84.3 COG0300@1|root,COG0300@2|Bacteria,1QUNR@1224|Proteobacteria,2TW24@28211|Alphaproteobacteria,2K1AC@204457|Sphingomonadales 204457|Sphingomonadales S COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) - - - - - - - - - - - - adh_short k59_14381_1 1121921.KB898707_gene975 1e-50 177.0 COG5565@1|root,COG5565@2|Bacteria,1R6R3@1224|Proteobacteria,1RY0J@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Terminase-like family - - - - - - - - - - - - Terminase_6,Terminase_6C k59_748057_1 715451.ambt_20755 1.74e-22 87.8 COG3311@1|root,COG3311@2|Bacteria,1NGB9@1224|Proteobacteria 1224|Proteobacteria K Transcriptional regulator - - - ko:K07733 - - - - ko00000,ko03000 - - - Phage_AlpA k59_748057_2 1121937.AUHJ01000002_gene3633 3.33e-45 154.0 COG0582@1|root,COG0582@2|Bacteria,1PSPA@1224|Proteobacteria,1S8I1@1236|Gammaproteobacteria,46DN5@72275|Alteromonadaceae 1236|Gammaproteobacteria L Integrase - - - - - - - - - - - - Integrase_1,Phage_int_SAM_2 k59_635350_1 1088721.NSU_3890 4.14e-96 301.0 COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,2TS2B@28211|Alphaproteobacteria,2K04E@204457|Sphingomonadales 204457|Sphingomonadales L DNA helicase uvrD - 3.6.4.12 ko:K03657 ko03420,ko03430,map03420,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - UvrD-helicase,UvrD_C k59_1200469_1 644282.Deba_3094 1.29e-24 109.0 COG1541@1|root,COG1541@2|Bacteria,1MV1W@1224|Proteobacteria,42PY9@68525|delta/epsilon subdivisions,2WMGG@28221|Deltaproteobacteria 28221|Deltaproteobacteria H coenzyme F390 - - 6.2.1.30 ko:K01912 ko00360,ko01120,ko05111,map00360,map01120,map05111 - R02539 RC00004,RC00014 ko00000,ko00001,ko01000 - - - AMP-binding k59_1031659_1 314230.DSM3645_29431 6.02e-99 301.0 COG1139@1|root,COG1139@2|Bacteria,2IX00@203682|Planctomycetes 203682|Planctomycetes C electron transport protein ykgF-putative 4Fe-4S containing oxidoreductase - - - ko:K18929 - - - - ko00000 - - - DUF3390,Fer4_8,LUD_dom k59_1765237_1 1123257.AUFV01000003_gene1172 9.02e-32 122.0 COG1028@1|root,COG1028@2|Bacteria,1MUPY@1224|Proteobacteria,1RMCB@1236|Gammaproteobacteria,1X4MA@135614|Xanthomonadales 135614|Xanthomonadales IQ Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis fabG - 1.1.1.100 ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 k59_691882_1 1449076.JOOE01000001_gene2027 1.12e-27 112.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,2TQR7@28211|Alphaproteobacteria,2K0BV@204457|Sphingomonadales 204457|Sphingomonadales NT methyl-accepting chemotaxis protein - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - CHASE3,MCPsignal,dCache_1 k59_691882_2 158500.BV97_04539 1.49e-28 113.0 COG2382@1|root,COG2382@2|Bacteria,1QU4Q@1224|Proteobacteria,2UCAB@28211|Alphaproteobacteria,2K2IZ@204457|Sphingomonadales 204457|Sphingomonadales P Putative esterase - - - ko:K07214 - - - - ko00000 - - - Esterase k59_1087238_1 1122137.AQXF01000001_gene2941 2.11e-135 392.0 COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,2TS1R@28211|Alphaproteobacteria 28211|Alphaproteobacteria I Belongs to the thiolase family - - 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N k59_1087238_2 571166.KI421509_gene3610 1.46e-14 73.6 COG1960@1|root,COG1960@2|Bacteria,1MU20@1224|Proteobacteria,2TQJS@28211|Alphaproteobacteria 28211|Alphaproteobacteria I acyl-CoA dehydrogenase MA20_19860 - 1.3.8.7 ko:K00249 ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320 M00013,M00036,M00087 R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754 RC00052,RC00068,RC00076,RC00095,RC00148,RC00246 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_C,Acyl-CoA_dh_M,Acyl-CoA_dh_N,AcylCoA_DH_N k59_1370438_1 640081.Dsui_0469 6.79e-23 103.0 COG0859@1|root,COG0859@2|Bacteria,1MYZA@1224|Proteobacteria,2VRSM@28216|Betaproteobacteria,2KVQV@206389|Rhodocyclales 206389|Rhodocyclales M Glycosyltransferase family 9 (heptosyltransferase) - - - ko:K02849 ko00540,ko01100,map00540,map01100 M00080 - - ko00000,ko00001,ko00002,ko01000,ko01003,ko01005 - GT9 - Glyco_transf_9 k59_1652687_1 497964.CfE428DRAFT_5240 9.16e-64 203.0 COG2326@1|root,COG2326@2|Bacteria,46SAH@74201|Verrucomicrobia 74201|Verrucomicrobia S Polyphosphate kinase 2 (PPK2) - - - - - - - - - - - - PPK2 k59_183725_1 518766.Rmar_1104 5.49e-18 78.2 COG0080@1|root,COG0080@2|Bacteria,4NM60@976|Bacteroidetes,1FJBP@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes J Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors rplK GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02867 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L11,Ribosomal_L11_N k59_183725_2 290398.Csal_0409 6.49e-46 153.0 COG0250@1|root,COG0250@2|Bacteria,1MU14@1224|Proteobacteria,1RMW0@1236|Gammaproteobacteria,1XHMM@135619|Oceanospirillales 135619|Oceanospirillales K Participates in transcription elongation, termination and antitermination nusG - - ko:K02601 - - - - ko00000,ko03009,ko03021 - - - KOW,NusG k59_1539717_1 1335757.SPICUR_02635 4.54e-31 112.0 COG2863@1|root,COG2863@2|Bacteria,1MZU1@1224|Proteobacteria,1SBJR@1236|Gammaproteobacteria,1X1EA@135613|Chromatiales 135613|Chromatiales C Cytochrome c - - - - - - - - - - - - Cytochrom_C k59_1426049_1 314225.ELI_08205 6.43e-250 690.0 COG0050@1|root,COG0050@2|Bacteria,1MVC0@1224|Proteobacteria,2TQP8@28211|Alphaproteobacteria,2K177@204457|Sphingomonadales 204457|Sphingomonadales J This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis tuf - - ko:K02358 - - - - ko00000,ko03012,ko03029,ko04147 - - - GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3 k59_1426049_2 1089549.AZUQ01000001_gene1727 1.33e-06 49.7 COG0480@1|root,COG0480@2|Bacteria,2GKB3@201174|Actinobacteria,4EXUW@85014|Glycomycetales 201174|Actinobacteria J Elongation factor G, domain IV fusA GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944 - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2 k59_1087248_1 1380390.JIAT01000009_gene545 3.32e-82 266.0 COG0296@1|root,COG0296@2|Bacteria,2GJ5C@201174|Actinobacteria,4CP7U@84995|Rubrobacteria 84995|Rubrobacteria G Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position glgB - 2.4.1.18 ko:K00700 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R02110 - ko00000,ko00001,ko00002,ko01000,ko04147 - CBM48,GH13 - Alpha-amylase,Alpha-amylase_C,CBM_48 k59_973512_1 313590.MED134_01655 3.81e-47 152.0 COG0184@1|root,COG0184@2|Bacteria,4NS7U@976|Bacteroidetes,1I3ZI@117743|Flavobacteriia,37FCZ@326319|Dokdonia 976|Bacteroidetes J Ribosomal_S15 rpsO GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - ko:K02956 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S15 k59_805427_1 702113.PP1Y_AT26349 8.25e-91 277.0 COG0842@1|root,COG0842@2|Bacteria,1MW5R@1224|Proteobacteria,2TU59@28211|Alphaproteobacteria,2K8NF@204457|Sphingomonadales 204457|Sphingomonadales U ABC-2 family transporter protein - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane_3 k59_805429_1 511062.GU3_04340 1.02e-33 130.0 COG0768@1|root,COG0768@2|Bacteria,1MUNY@1224|Proteobacteria,1RNGW@1236|Gammaproteobacteria,1Y3IV@135624|Aeromonadales 135624|Aeromonadales M Catalyzes cross-linking of the peptidoglycan cell wall at the division septum ftsI - 3.4.16.4 ko:K03587 ko00550,ko01501,map00550,map01501 - - - ko00000,ko00001,ko01000,ko01011,ko03036 - - - PBP_dimer,Transpeptidase k59_805429_2 1095772.CAHH01000059_gene1405 3.1e-05 48.5 COG0769@1|root,COG0769@2|Bacteria,2GIS2@201174|Actinobacteria 201174|Actinobacteria M acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan murE GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008765,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016874,GO:0016879,GO:0016881,GO:0030203,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 6.3.2.13 ko:K01928 ko00300,ko00550,map00300,map00550 - R02788 RC00064,RC00090 ko00000,ko00001,ko01000,ko01011 - - iNJ661.Rv2158c Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_1256810_2 314345.SPV1_05647 1.21e-27 106.0 COG0412@1|root,COG0412@2|Bacteria,1MW7S@1224|Proteobacteria 1224|Proteobacteria Q dienelactone hydrolase MA20_42490 - 3.1.1.45 ko:K01061 ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130 - R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222 RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686 ko00000,ko00001,ko01000 - - - DLH k59_1765261_1 511145.b2218 1.74e-195 567.0 COG0642@1|root,COG0784@1|root,COG0784@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,1RQCU@1236|Gammaproteobacteria,3XMTU@561|Escherichia 1236|Gammaproteobacteria T Component of the Rcs signaling system, which controls transcription of numerous genes. RcsC functions as a membrane- associated protein kinase that phosphorylates RcsD in response to environmental signals. The phosphoryl group is then transferred to the response regulator RcsB rcsC GO:0000155,GO:0000160,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006970,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009628,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0023014,GO:0023052,GO:0033554,GO:0035556,GO:0036211,GO:0042710,GO:0043170,GO:0043412,GO:0044010,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0044764,GO:0046777,GO:0050789,GO:0050794,GO:0050896,GO:0051704,GO:0051716,GO:0065007,GO:0071214,GO:0071470,GO:0071704,GO:0071944,GO:0104004,GO:0140096,GO:1901564 2.7.13.3 ko:K07677 ko02020,ko02026,map02020,map02026 M00474 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA,RcsC,Response_reg k59_183749_3 948106.AWZT01000011_gene2060 1.47e-26 105.0 COG0115@1|root,COG0115@2|Bacteria,1MVB0@1224|Proteobacteria,2VHR7@28216|Betaproteobacteria,1JZZF@119060|Burkholderiaceae 28216|Betaproteobacteria E Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family ilvE - 2.6.1.42 ko:K00826 ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00036,M00119,M00570 R01090,R01214,R02199,R10991 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_4 k59_1595718_1 391037.Sare_3556 3.91e-21 95.9 COG2843@1|root,COG2843@2|Bacteria,2GK15@201174|Actinobacteria,4DBUA@85008|Micromonosporales 201174|Actinobacteria M Bacterial capsule synthesis protein PGA_cap - - - ko:K07282 - - - - ko00000 - - - PGA_cap k59_239673_1 627192.SLG_06030 3.36e-45 154.0 COG2813@1|root,COG2813@2|Bacteria,1RHAE@1224|Proteobacteria,2U5V5@28211|Alphaproteobacteria,2K42K@204457|Sphingomonadales 204457|Sphingomonadales J Protein of unknown function (DUF938) - - - - - - - - - - - - DUF938 k59_239673_2 394221.Mmar10_3062 3.13e-42 151.0 COG0491@1|root,COG0491@2|Bacteria,1PKW8@1224|Proteobacteria,2TUW8@28211|Alphaproteobacteria,43XAS@69657|Hyphomonadaceae 28211|Alphaproteobacteria S Metallo-beta-lactamase superfamily - - - - - - - - - - - - Lactamase_B k59_917921_1 331869.BAL199_28660 4.79e-60 196.0 COG0500@1|root,COG2226@2|Bacteria,1MW7J@1224|Proteobacteria,2TSZC@28211|Alphaproteobacteria 28211|Alphaproteobacteria Q O-methyltransferase, family 2 crtF - 2.1.1.210 ko:K09846 ko00906,ko01100,map00906,map01100 - R07521,R07524,R07527,R07529,R07533,R07535 RC00003,RC02082 ko00000,ko00001,ko01000 - - - Dimerisation2,Methyltransf_2 k59_409458_1 1122137.AQXF01000001_gene3005 1.93e-114 345.0 COG2200@1|root,COG2200@2|Bacteria,1N299@1224|Proteobacteria,2TT4R@28211|Alphaproteobacteria 28211|Alphaproteobacteria T EAL domain yfgF - - - - - - - - - - - EAL k59_1595737_2 436308.Nmar_1108 1.17e-27 102.0 arCOG10576@1|root,arCOG10576@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_183762_1 1122137.AQXF01000003_gene2001 6.92e-70 221.0 COG3138@1|root,COG3138@2|Bacteria,1MWHC@1224|Proteobacteria,2TREF@28211|Alphaproteobacteria 28211|Alphaproteobacteria E N-succinyltransferase, beta subunit - - 2.3.1.109 ko:K00673 ko00330,ko01100,map00330,map01100 - R00832 RC00004,RC00064 ko00000,ko00001,ko01000 - - - AstA k59_183762_2 1122137.AQXF01000003_gene2000 6.79e-120 355.0 COG0624@1|root,COG0624@2|Bacteria,1MUSU@1224|Proteobacteria,2TRTW@28211|Alphaproteobacteria 28211|Alphaproteobacteria E COG0624 Acetylornithine deacetylase Succinyl-diaminopimelate desuccinylase and related deacylases MA20_32325 - 3.4.17.11 ko:K01295 - - - - ko00000,ko01000,ko01002 - - - M20_dimer,Peptidase_M20,Peptidase_M28 k59_1378443_1 1352941.M877_26675 7.07e-21 87.4 COG0599@1|root,COG0599@2|Bacteria 2|Bacteria S peroxiredoxin activity - - 4.1.1.44 ko:K01607 ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220 - R03470 RC00938 ko00000,ko00001,ko01000 - - - CMD k59_1378443_2 742738.HMPREF9460_03342 1.93e-06 47.8 COG1607@1|root,COG1607@2|Bacteria,1V3ZQ@1239|Firmicutes,24HF8@186801|Clostridia,2699I@186813|unclassified Clostridiales 186801|Clostridia I Thioesterase superfamily kal - 4.3.1.14 ko:K18014 ko00310,map00310 - R03030 RC00833 ko00000,ko00001,ko01000 - - - 4HBT k59_247593_1 1265505.ATUG01000003_gene710 1.32e-65 216.0 COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,42M5F@68525|delta/epsilon subdivisions,2WISF@28221|Deltaproteobacteria,2MIAR@213118|Desulfobacterales 28221|Deltaproteobacteria IQ PFAM AMP-dependent synthetase and ligase fadD - 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding,AMP-binding_C k59_980780_1 522306.CAP2UW1_4197 9.03e-68 216.0 COG0192@1|root,COG0192@2|Bacteria,1MUFQ@1224|Proteobacteria,2VH7U@28216|Betaproteobacteria,1KPV6@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria H Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme metK - 2.5.1.6 ko:K00789 ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230 M00034,M00035,M00368,M00609 R00177,R04771 RC00021,RC01211 ko00000,ko00001,ko00002,ko01000 - - - S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N k59_191271_1 1437425.CSEC_2336 3.19e-20 88.6 COG2070@1|root,COG2070@2|Bacteria,2JGSD@204428|Chlamydiae 204428|Chlamydiae S Nitronate monooxygenase - - - - - - - - - - - - NMO k59_1094648_1 395494.Galf_2704 1.05e-15 77.4 COG4137@1|root,COG4137@2|Bacteria,1R3YD@1224|Proteobacteria,2VK0H@28216|Betaproteobacteria,44V5D@713636|Nitrosomonadales 28216|Betaproteobacteria S Cytochrome C assembly protein ypjD - - - - - - - - - - - Cytochrom_C_asm k59_1094648_2 511.JT27_12230 6.7e-24 99.8 COG0541@1|root,COG0541@2|Bacteria,1MVIA@1224|Proteobacteria,2VJ3W@28216|Betaproteobacteria,3T1HR@506|Alcaligenaceae 28216|Betaproteobacteria U Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components ffh - 3.6.5.4 ko:K03106 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko01000,ko02044 3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9 - - SRP54,SRP54_N,SRP_SPB k59_79567_2 1209984.BN978_05051 3.49e-19 88.6 COG0384@1|root,COG0384@2|Bacteria,2GMX1@201174|Actinobacteria,234F4@1762|Mycobacteriaceae 201174|Actinobacteria S Phenazine biosynthesis protein, PhzF family phzF - - - - - - - - - - - PhzC-PhzF k59_586717_1 1380391.JIAS01000011_gene5146 2.47e-49 172.0 COG0402@1|root,COG0402@2|Bacteria,1MUFE@1224|Proteobacteria,2TR3A@28211|Alphaproteobacteria,2JPEJ@204441|Rhodospirillales 204441|Rhodospirillales F Amidohydrolase family - - 3.5.3.13 ko:K05603 ko00340,map00340 - R02286 RC00682 ko00000,ko00001,ko01000 - - - Amidohydro_1 k59_755535_1 1280948.HY36_11805 6.99e-35 127.0 COG0625@1|root,COG0625@2|Bacteria,1RHSK@1224|Proteobacteria,2U5GF@28211|Alphaproteobacteria,43Y6Q@69657|Hyphomonadaceae 28211|Alphaproteobacteria O Glutathione S-transferase, N-terminal domain yibF - 2.5.1.18 ko:K00799 ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418 - R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905 RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944 ko00000,ko00001,ko01000,ko02000 1.A.12.2.2,1.A.12.3.2 - - GST_C_2,GST_N_3 k59_528825_1 1121374.KB891575_gene1441 6.8e-05 44.7 COG0751@1|root,COG0751@2|Bacteria,1MV2F@1224|Proteobacteria,1RNR3@1236|Gammaproteobacteria 1236|Gammaproteobacteria J Glycyl-tRNA synthetase beta subunit glyS GO:0003674,GO:0003824,GO:0004812,GO:0004820,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006426,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.14 ko:K01879 ko00970,map00970 M00360 R03654 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iAPECO1_1312.APECO1_2891,iE2348C_1286.E2348C_3810,iECABU_c1320.ECABU_c40010,iECED1_1282.ECED1_4242,iECH74115_1262.ECH74115_4934,iECNA114_1301.ECNA114_3710,iECOK1_1307.ECOK1_4005,iECP_1309.ECP_3661,iECS88_1305.ECS88_3976,iECSF_1327.ECSF_3393,iECSP_1301.ECSP_4554,iECs_1301.ECs4442,iG2583_1286.G2583_4300,iUMN146_1321.UM146_17960,iUTI89_1310.UTI89_C4099,ic_1306.c4378 DALR_1,tRNA_synt_2f k59_528825_2 246195.DNO_1058 5.46e-47 162.0 COG0204@1|root,COG0204@2|Bacteria,1MY51@1224|Proteobacteria,1RQYC@1236|Gammaproteobacteria 1236|Gammaproteobacteria I Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family plsC - 2.3.1.51 ko:K00655 ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110 M00089 R02241,R09381 RC00004,RC00037,RC00039 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Acyltransferase k59_135139_2 378806.STAUR_3465 1.43e-20 92.8 COG0739@1|root,COG0739@2|Bacteria,1MY2X@1224|Proteobacteria,42U06@68525|delta/epsilon subdivisions,2WQXU@28221|Deltaproteobacteria,2YZNF@29|Myxococcales 28221|Deltaproteobacteria M Peptidase family M23 - - - - - - - - - - - - Peptidase_M23 k59_1378490_2 1229909.NSED_03195 1.79e-24 92.4 COG4023@1|root,arCOG02957@2157|Archaea,41SUS@651137|Thaumarchaeota 651137|Thaumarchaeota U Sec61beta family - - - - - - - - - - - - Sec61_beta k59_1208403_1 330214.NIDE3245 7.88e-42 150.0 COG2204@1|root,COG2204@2|Bacteria 2|Bacteria T phosphorelay signal transduction system - - - - - - - - - - - - HTH_8,Response_reg,Sigma54_activat k59_1208403_2 1449353.JQMQ01000005_gene1917 1.29e-08 57.8 COG0784@1|root,COG0840@1|root,COG1511@1|root,COG2770@1|root,COG4251@1|root,COG0784@2|Bacteria,COG0840@2|Bacteria,COG1511@2|Bacteria,COG2770@2|Bacteria,COG4251@2|Bacteria,2GKQX@201174|Actinobacteria,2NGU4@228398|Streptacidiphilus 201174|Actinobacteria T His Kinase A (phosphoacceptor) domain osaA - - - - - - - - - - - GAF_2,HAMP,HATPase_c,HisKA,Response_reg k59_1660441_1 199310.c0153 1.14e-139 416.0 COG4993@1|root,COG4993@2|Bacteria,1MUQX@1224|Proteobacteria,1RN5D@1236|Gammaproteobacteria,3XPH2@561|Escherichia 1236|Gammaproteobacteria G Glucose dehydrogenase gcd GO:0000287,GO:0003674,GO:0003824,GO:0004344,GO:0005488,GO:0005575,GO:0008150,GO:0008152,GO:0008876,GO:0016020,GO:0016021,GO:0016491,GO:0016614,GO:0016901,GO:0019842,GO:0031224,GO:0031406,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0044425,GO:0046872,GO:0048037,GO:0048038,GO:0048039,GO:0055114,GO:0070968,GO:0097159,GO:1901363 1.1.5.2 ko:K00117 ko00030,ko01100,ko01110,ko01130,map00030,map01100,map01110,map01130 - R06620 RC00066 ko00000,ko00001,ko01000 - - iEC55989_1330.EC55989_0117,iECIAI1_1343.ECIAI1_0122,iECW_1372.ECW_m0121,iEKO11_1354.EKO11_3792,iWFL_1372.ECW_m0121 PQQ k59_1094690_1 1249627.D779_1208 4.8e-23 97.4 COG0119@1|root,COG0119@2|Bacteria,1MUNQ@1224|Proteobacteria,1RMWE@1236|Gammaproteobacteria,1WWU2@135613|Chromatiales 135613|Chromatiales E Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) leuA - 2.3.3.13 ko:K01649 ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230 M00432 R01213 RC00004,RC00470,RC02754 br01601,ko00000,ko00001,ko00002,ko01000 - - - HMGL-like,LeuA_dimer k59_473115_1 690850.Desaf_0933 3.71e-41 148.0 2DN8B@1|root,32W2U@2|Bacteria,1R03I@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_305257_1 159087.Daro_0726 6.76e-40 151.0 COG0643@1|root,COG2198@1|root,COG0643@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,2VI5B@28216|Betaproteobacteria,2KVAE@206389|Rhodocyclales 206389|Rhodocyclales NT Signal transducing histidine kinase, homodimeric domain - - 2.7.13.3 ko:K03407 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 - - - CheW,H-kinase_dim,HATPase_c,Hpt k59_417260_1 377629.TERTU_3676 2.03e-68 214.0 COG0625@1|root,COG0625@2|Bacteria,1MXJD@1224|Proteobacteria,1RP12@1236|Gammaproteobacteria,2PMS3@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria O Glutathione S-transferase, C-terminal domain sspA GO:0001000,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0006950,GO:0008150,GO:0009605,GO:0009889,GO:0009891,GO:0009893,GO:0009991,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0019899,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031667,GO:0042594,GO:0043175,GO:0044424,GO:0044444,GO:0044464,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0070063,GO:0080090,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141 - ko:K03599 - - - - ko00000,ko02000,ko03021 1.A.12.3.1 - - GST_C,GST_N,GST_N_3 k59_417260_2 1123279.ATUS01000002_gene194 8.23e-21 85.5 COG2969@1|root,COG2969@2|Bacteria,1MZ2Q@1224|Proteobacteria,1S8WT@1236|Gammaproteobacteria,1J6MW@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Stringent starvation protein B sspB GO:0000502,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0008150,GO:0009376,GO:0009893,GO:0009894,GO:0009896,GO:0010604,GO:0019222,GO:0019899,GO:0031597,GO:0032781,GO:0032991,GO:0042176,GO:0042802,GO:0042803,GO:0043085,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043462,GO:0044093,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0045732,GO:0046983,GO:0048518,GO:0050789,GO:0050790,GO:0051117,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0051336,GO:0051345,GO:0060255,GO:0065007,GO:0065009,GO:0080090,GO:0097159,GO:1901363,GO:1902494,GO:1904949,GO:1905368,GO:1905369,GO:1990904 - ko:K03600 - - - - ko00000,ko03021 - - - SspB k59_305258_1 1137799.GZ78_11985 4.67e-25 106.0 COG2015@1|root,COG2015@2|Bacteria,1MU82@1224|Proteobacteria,1S468@1236|Gammaproteobacteria,1XS3I@135619|Oceanospirillales 1236|Gammaproteobacteria Q Alkyl sulfatase dimerisation - - - - - - - - - - - - Alkyl_sulf_dimr,Lactamase_B k59_305258_2 247633.GP2143_10692 1.26e-36 144.0 COG1680@1|root,COG1680@2|Bacteria,1MVPR@1224|Proteobacteria 1224|Proteobacteria V COG1680 Beta-lactamase class C and other penicillin binding proteins - - - - - - - - - - - - Beta-lactamase k59_1604064_1 1122137.AQXF01000003_gene2286 2.13e-122 365.0 COG0768@1|root,COG0768@2|Bacteria,1MUNY@1224|Proteobacteria,2TSHQ@28211|Alphaproteobacteria 28211|Alphaproteobacteria M Cell division protein FtsI penicillin-binding protein 2 ftsI - 3.4.16.4 ko:K03587 ko00550,ko01501,map00550,map01501 - - - ko00000,ko00001,ko01000,ko01011,ko03036 - - - PBP_dimer,Transpeptidase k59_1151575_1 1168067.JAGP01000001_gene593 4e-74 238.0 COG3239@1|root,COG3239@2|Bacteria,1P79B@1224|Proteobacteria,1RNY0@1236|Gammaproteobacteria,4624H@72273|Thiotrichales 72273|Thiotrichales I Fatty acid desaturase - - - - - - - - - - - - FA_desaturase k59_1151575_2 398527.Bphyt_5225 1.16e-37 135.0 COG1116@1|root,COG1116@2|Bacteria,1MUDV@1224|Proteobacteria,2VMYS@28216|Betaproteobacteria,1K5HY@119060|Burkholderiaceae 28216|Betaproteobacteria P abc transporter cmpD_2 - - ko:K02049 - M00188 - - ko00000,ko00002,ko02000 3.A.1.16,3.A.1.17 - - ABC_tran k59_980826_1 585531.HMPREF0063_12522 1.57e-68 218.0 COG0183@1|root,COG0183@2|Bacteria,2GJAC@201174|Actinobacteria,4DN7H@85009|Propionibacteriales 201174|Actinobacteria I Thiolase, C-terminal domain - - 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N k59_980826_2 1240350.AMZE01000075_gene4392 2.32e-68 225.0 COG1960@1|root,COG1960@2|Bacteria,1P4V3@1224|Proteobacteria,1RZBS@1236|Gammaproteobacteria 1236|Gammaproteobacteria I acyl-CoA dehydrogenase - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_N k59_980826_3 745310.G432_04810 4.89e-92 280.0 COG1960@1|root,COG1960@2|Bacteria,1MVJC@1224|Proteobacteria,2TTRD@28211|Alphaproteobacteria,2K16D@204457|Sphingomonadales 204457|Sphingomonadales I acyl-CoA dehydrogenase - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_247676_1 543913.D521_1117 2.77e-16 79.7 COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2VHK8@28216|Betaproteobacteria 28216|Betaproteobacteria S protein conserved in bacteria - - - - - - - - - - - - TctC k59_1040172_1 1415778.JQMM01000001_gene55 3.93e-124 373.0 COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,1RPCU@1236|Gammaproteobacteria,1J4ET@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S COG0488 ATPase components of ABC transporters with duplicated ATPase domains uup GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0008150,GO:0009314,GO:0009628,GO:0010528,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019219,GO:0019222,GO:0031323,GO:0044424,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051171,GO:0060255,GO:0065007,GO:0070894,GO:0071944,GO:0080090,GO:0097159,GO:1901363 - ko:K15738 - - - - ko00000,ko02000 3.A.1.120.6 - - ABC_tran,ABC_tran_CTD,ABC_tran_Xtn k59_870405_2 189753.AXAS01000073_gene7676 2.25e-36 135.0 COG1653@1|root,COG1653@2|Bacteria,1PEBV@1224|Proteobacteria,2V8NU@28211|Alphaproteobacteria,3K0ZY@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria G Bacterial extracellular solute-binding protein - - - ko:K02027 - M00207 - - ko00000,ko00002,ko02000 3.A.1.1 - - SBP_bac_8 k59_247678_1 1415778.JQMM01000001_gene1282 8.63e-69 223.0 COG2206@1|root,COG2206@2|Bacteria,1MW7F@1224|Proteobacteria,1RPEZ@1236|Gammaproteobacteria,1J5MY@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T COG2206 HD-GYP domain - - - - - - - - - - - - DUF3391,HD,HD_5 k59_1433420_1 1122138.AQUZ01000010_gene5065 1.94e-07 58.2 COG0500@1|root,COG2226@2|Bacteria,2IECW@201174|Actinobacteria 201174|Actinobacteria Q Methyltransferase type 11 - - - - - - - - - - - - Methyltransf_11 k59_1208443_1 504487.JCM19302_2705 2.17e-51 170.0 COG2207@1|root,COG2207@2|Bacteria,4NE6T@976|Bacteroidetes,1HX87@117743|Flavobacteriia 976|Bacteroidetes K transcriptional regulator - - - - - - - - - - - - AraC_binding,HTH_18 k59_1208443_2 1120951.AUBG01000011_gene2454 5.36e-50 164.0 COG1418@1|root,COG1418@2|Bacteria,4NEZY@976|Bacteroidetes,1HX55@117743|Flavobacteriia 976|Bacteroidetes S HD superfamily hydrolase - - - ko:K06950 - - - - ko00000 - - - HD k59_1040183_1 640510.BC1001_1563 1.54e-26 112.0 COG0642@1|root,COG0642@2|Bacteria,1QTSX@1224|Proteobacteria,2W1JF@28216|Betaproteobacteria,1K38S@119060|Burkholderiaceae 28216|Betaproteobacteria T histidine kinase HAMP region domain protein - - 2.7.13.3 ko:K07645 ko02020,ko02024,map02020,map02024 M00453 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - 2CSK_N,HATPase_c,HisKA k59_1772337_1 864069.MicloDRAFT_00020980 3.75e-17 92.4 COG0840@1|root,COG0840@2|Bacteria,1NJXF@1224|Proteobacteria,2TTNX@28211|Alphaproteobacteria,1JQS4@119045|Methylobacteriaceae 28211|Alphaproteobacteria NT type IV pilus assembly PilZ - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - MCPsignal,PilZ k59_1263764_2 644801.Psest_1761 1.88e-38 135.0 COG3088@1|root,COG3088@2|Bacteria,1MZZ5@1224|Proteobacteria,1S9DV@1236|Gammaproteobacteria,1Z06C@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria P subunit of a heme lyase ccmH GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008152,GO:0009897,GO:0009986,GO:0009987,GO:0015035,GO:0015036,GO:0016020,GO:0016043,GO:0016491,GO:0016667,GO:0017004,GO:0022607,GO:0031224,GO:0031226,GO:0031233,GO:0031237,GO:0034622,GO:0043933,GO:0044085,GO:0044425,GO:0044459,GO:0044464,GO:0055114,GO:0065003,GO:0071840,GO:0071944,GO:0098552,GO:0098567 - ko:K02200 - - - - ko00000 - - - CcmH k59_1263764_3 1453501.JELR01000001_gene2673 4.27e-08 53.1 COG0526@1|root,COG0526@2|Bacteria,1RI3N@1224|Proteobacteria,1S5YV@1236|Gammaproteobacteria,466IK@72275|Alteromonadaceae 1236|Gammaproteobacteria CO Thiol disulfide interchange protein dsbE GO:0003674,GO:0003756,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008152,GO:0009897,GO:0009986,GO:0009987,GO:0015036,GO:0016020,GO:0016043,GO:0016491,GO:0016667,GO:0016853,GO:0016860,GO:0016864,GO:0017004,GO:0022607,GO:0031224,GO:0031226,GO:0031233,GO:0031237,GO:0034622,GO:0043933,GO:0044085,GO:0044425,GO:0044459,GO:0044464,GO:0055114,GO:0065003,GO:0071840,GO:0071944,GO:0098552,GO:0098567,GO:0140096 - ko:K02199 - - - - ko00000,ko03110 - - - Redoxin k59_361903_1 436308.Nmar_1786 5.81e-93 277.0 COG4221@1|root,arCOG01265@2157|Archaea,41S66@651137|Thaumarchaeota 651137|Thaumarchaeota I Belongs to the short-chain dehydrogenases reductases (SDR) family - - - - - - - - - - - - adh_short k59_361903_2 1229909.NSED_09570 2.16e-38 129.0 COG3582@1|root,arCOG01769@2157|Archaea,41SUB@651137|Thaumarchaeota 651137|Thaumarchaeota S zinc finger - - - - - - - - - - - - zf-AN1 k59_361903_3 1229909.NSED_09575 1.78e-17 75.1 arCOG08809@1|root,arCOG08809@2157|Archaea,41TAB@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_79658_1 1123020.AUIE01000016_gene1982 1.71e-38 142.0 29MQ2@1|root,308MT@2|Bacteria,1REUR@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_473147_1 742733.HMPREF9469_01363 7.07e-06 53.5 COG0683@1|root,COG0683@2|Bacteria,1TPQ2@1239|Firmicutes,248H1@186801|Clostridia,21XNG@1506553|Lachnoclostridium 186801|Clostridia E Receptor family ligand binding region - - - ko:K01999 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - Peripla_BP_6 k59_755593_1 548479.HMPREF0573_11063 6.39e-21 95.5 COG1134@1|root,COG1134@2|Bacteria,2GIVF@201174|Actinobacteria,4D3DP@85005|Actinomycetales 201174|Actinobacteria GM ABC transporter, ATP-binding protein rfbB2 - 3.6.3.40 ko:K01990,ko:K09691,ko:K09693 ko02010,map02010 M00250,M00251,M00254 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1,3.A.1.103,3.A.1.104 - - ABC_tran,Wzt_C k59_1716893_1 572547.Amico_0724 1.29e-35 133.0 COG3872@1|root,COG3872@2|Bacteria,3TAH6@508458|Synergistetes 508458|Synergistetes S Protein of unknown function (DUF1385) - - - - - - - - - - - - DUF1385 k59_1263776_1 96561.Dole_3254 5.72e-38 146.0 COG2885@1|root,COG3203@1|root,COG4719@1|root,COG2885@2|Bacteria,COG3203@2|Bacteria,COG4719@2|Bacteria,1QW22@1224|Proteobacteria,42NCQ@68525|delta/epsilon subdivisions,2WMJP@28221|Deltaproteobacteria,2MMHS@213118|Desulfobacterales 28221|Deltaproteobacteria M TIGRFAM conserved repeat domain - - - - - - - - - - - - DUF11,OmpA k59_1433435_1 1521187.JPIM01000016_gene3700 2.36e-35 135.0 COG1249@1|root,COG1249@2|Bacteria,2G5MR@200795|Chloroflexi,374XR@32061|Chloroflexia 32061|Chloroflexia C PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase - - 1.8.1.4 ko:K00382 ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00036,M00307,M00532 R00209,R01221,R01698,R03815,R07618,R08549 RC00004,RC00022,RC00583,RC02742,RC02833,RC02834 br01601,ko00000,ko00001,ko00002,ko01000,ko04147 - - - Pyr_redox_2,Pyr_redox_dim k59_361925_2 864069.MicloDRAFT_00046710 7.02e-33 121.0 COG1622@1|root,COG1622@2|Bacteria,1MVYW@1224|Proteobacteria,2TT5C@28211|Alphaproteobacteria,1JU8U@119045|Methylobacteriaceae 28211|Alphaproteobacteria C PFAM Cytochrome C oxidase subunit II coxM GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006119,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009319,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016310,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0032991,GO:0034641,GO:0042773,GO:0044237,GO:0044238,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0045333,GO:0046034,GO:0046483,GO:0055086,GO:0055114,GO:0070069,GO:0071704,GO:0071944,GO:0072521,GO:0098796,GO:1901135,GO:1901360,GO:1901564,GO:1902494 1.9.3.1 ko:K02275 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.4,3.D.4.6 - - COX2 k59_1491717_2 1034769.KB910518_gene3988 7.09e-13 68.6 COG0212@1|root,COG0212@2|Bacteria,1VA91@1239|Firmicutes,4HM35@91061|Bacilli,26ZIC@186822|Paenibacillaceae 91061|Bacilli H Belongs to the 5-formyltetrahydrofolate cyclo-ligase family fthC GO:0003674,GO:0003824,GO:0006082,GO:0006575,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009396,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016882,GO:0018130,GO:0019438,GO:0019752,GO:0030272,GO:0034641,GO:0035999,GO:0042398,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0046653,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.3.2 ko:K01934 ko00670,ko01100,map00670,map01100 - R02301 RC00183 ko00000,ko00001,ko01000 - - - 5-FTHF_cyc-lig k59_700035_1 305700.B447_18483 8.37e-12 70.9 COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1144@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1144@2|Bacteria,1MVM0@1224|Proteobacteria,2VN9C@28216|Betaproteobacteria,2M00F@206389|Rhodocyclales 206389|Rhodocyclales C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin - - 1.2.7.1 ko:K03737 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00173,M00307 R01196,R10866 RC00004,RC02742 br01601,ko00000,ko00001,ko00002,ko01000 - - - EKR,Fer4_16,PFOR_II,POR,POR_N,TPP_enzyme_C k59_135249_1 1144305.PMI02_02233 1.03e-94 287.0 COG0772@1|root,COG0772@2|Bacteria,1MVDB@1224|Proteobacteria,2TQSA@28211|Alphaproteobacteria,2K0IS@204457|Sphingomonadales 204457|Sphingomonadales D Belongs to the SEDS family ftsW - - ko:K03588 ko04112,map04112 - - - ko00000,ko00001,ko02000,ko03036 2.A.103.1 - - FTSW_RODA_SPOVE k59_1040218_1 71139.XP_010046010.1 5.27e-90 272.0 KOG4853@1|root,KOG4853@2759|Eukaryota,37VMJ@33090|Viridiplantae,3GJ4H@35493|Streptophyta 35493|Streptophyta S mitotic sister chromatid biorientation - - - - - - - - - - - - - k59_135256_1 1150626.PHAMO_220102 3.64e-98 296.0 COG0253@1|root,COG0253@2|Bacteria,1MWDH@1224|Proteobacteria,2TUF2@28211|Alphaproteobacteria,2JPZS@204441|Rhodospirillales 204441|Rhodospirillales E Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan dapF - 5.1.1.7 ko:K01778 ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00527 R02735 RC00302 ko00000,ko00001,ko00002,ko01000 - - - DAP_epimerase k59_135256_2 1122137.AQXF01000007_gene3547 6.92e-86 265.0 COG0621@1|root,COG0621@2|Bacteria,1MUCS@1224|Proteobacteria,2TRYD@28211|Alphaproteobacteria 28211|Alphaproteobacteria J MiaB-like tRNA modifying enzyme mtaB GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016782,GO:0034470,GO:0034641,GO:0034660,GO:0035596,GO:0035598,GO:0035600,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0050497,GO:0071704,GO:0090304,GO:1901360 2.8.4.5 ko:K18707 - - R10649 RC00003,RC03221 ko00000,ko01000,ko03016 - - - Radical_SAM,UPF0004 k59_1378596_1 1380391.JIAS01000012_gene4525 3.05e-88 278.0 COG2303@1|root,COG2303@2|Bacteria,1MV19@1224|Proteobacteria,2TQKQ@28211|Alphaproteobacteria,2JVAC@204441|Rhodospirillales 204441|Rhodospirillales E GMC oxidoreductase - - - - - - - - - - - - GMC_oxred_C,GMC_oxred_N k59_305344_1 867903.ThesuDRAFT_01198 8.19e-42 153.0 COG0508@1|root,COG0508@2|Bacteria,1TR5N@1239|Firmicutes,247Q5@186801|Clostridia 186801|Clostridia C Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex - - 2.3.1.12 ko:K00627 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200 M00307 R00209,R02569 RC00004,RC02742,RC02857 br01601,ko00000,ko00001,ko00002,ko01000 - - - 2-oxoacid_dh,Biotin_lipoyl,CMD,E3_binding k59_1433463_1 1380393.JHVP01000002_gene1675 1.03e-76 239.0 COG1028@1|root,COG1028@2|Bacteria,2GNUM@201174|Actinobacteria,4EU5K@85013|Frankiales 201174|Actinobacteria IQ Belongs to the short-chain dehydrogenases reductases (SDR) family - - - - - - - - - - - - adh_short,adh_short_C2 k59_586868_1 1485544.JQKP01000012_gene2149 2.25e-74 230.0 COG0476@1|root,COG0476@2|Bacteria,1MW7H@1224|Proteobacteria,2VI1U@28216|Betaproteobacteria,44UZK@713636|Nitrosomonadales 28216|Betaproteobacteria H PFAM UBA THIF-type NAD FAD binding protein thiF - 2.7.7.80 ko:K21029 ko04122,map04122 - R07459 RC00043 ko00000,ko00001,ko01000 - - - ThiF k59_700066_1 1240349.ANGC01000026_gene3750 4.69e-40 151.0 COG0477@1|root,COG2814@2|Bacteria,2GM2G@201174|Actinobacteria,4FZ0N@85025|Nocardiaceae 201174|Actinobacteria EGP Sugar (and other) transporter vanK - - - - - - - - - - - MFS_1,MFS_2,MFS_4 k59_700066_2 1292034.OR37_03175 2.22e-81 250.0 COG2070@1|root,COG2070@2|Bacteria,1MWPC@1224|Proteobacteria,2TQRT@28211|Alphaproteobacteria,2KFXW@204458|Caulobacterales 204458|Caulobacterales S PFAM 2-nitropropane dioxygenase NPD - - 1.13.12.16 ko:K00459 ko00910,map00910 - R00025 RC02541,RC02759 ko00000,ko00001,ko01000 - - - NMO k59_1208521_1 1144305.PMI02_05023 4.11e-89 284.0 COG0457@1|root,COG3914@1|root,COG0457@2|Bacteria,COG3914@2|Bacteria,1MVMG@1224|Proteobacteria,2TRVB@28211|Alphaproteobacteria,2K1FV@204457|Sphingomonadales 204457|Sphingomonadales O Glycosyl transferase family 41 - - - - - - - - - - - - Glyco_transf_41,TPR_1,TPR_11,TPR_16,TPR_2,TPR_6,TPR_8 k59_1433474_1 1207063.P24_00060 9.93e-87 280.0 COG0243@1|root,COG3383@1|root,COG0243@2|Bacteria,COG3383@2|Bacteria,1MW3N@1224|Proteobacteria,2TTPX@28211|Alphaproteobacteria,2JPWY@204441|Rhodospirillales 204441|Rhodospirillales C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - - - - - - - - - - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding k59_755630_1 1122137.AQXF01000001_gene3141 1.68e-52 166.0 COG0227@1|root,COG0227@2|Bacteria,1MZ57@1224|Proteobacteria,2UBQU@28211|Alphaproteobacteria 28211|Alphaproteobacteria J Belongs to the bacterial ribosomal protein bL28 family rpmB GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - ko:K02902 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L28 k59_306556_2 58123.JOFJ01000005_gene1350 2.14e-19 87.4 COG0837@1|root,COG0837@2|Bacteria,2IBFZ@201174|Actinobacteria,4EH3E@85012|Streptosporangiales 201174|Actinobacteria G Glucokinase glk - 2.7.1.2 ko:K00845 ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200 M00001,M00549 R00299,R01600,R01786 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - Glucokinase k59_248865_1 211586.SO_4266 7.26e-98 296.0 COG3177@1|root,COG3177@2|Bacteria,1MV69@1224|Proteobacteria,1RRCR@1236|Gammaproteobacteria,2QB9N@267890|Shewanellaceae 1236|Gammaproteobacteria H Adenylyltransferase that mediates the addition of adenosine 5'-monophosphate (AMP) to specific residues of target proteins - GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0006464,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0017076,GO:0018117,GO:0018175,GO:0019538,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0036211,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0046872,GO:0046983,GO:0070566,GO:0070733,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901564 - - - - - - - - - - Fic,Fic_N k59_1321981_1 426114.THI_2956 1.04e-40 151.0 COG5421@1|root,COG5421@2|Bacteria,1R3NX@1224|Proteobacteria,2VNNI@28216|Betaproteobacteria,1KNZB@119065|unclassified Burkholderiales 28216|Betaproteobacteria L Evidence 2b Function of strongly homologous gene - - - - - - - - - - - - DDE_Tnp_1 k59_1209693_1 1125863.JAFN01000001_gene1657 6.4e-42 150.0 COG1492@1|root,COG1492@2|Bacteria,1MUFY@1224|Proteobacteria,42M9K@68525|delta/epsilon subdivisions,2WJ22@28221|Deltaproteobacteria 28221|Deltaproteobacteria H Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation cobQ - 6.3.5.10 ko:K02232 ko00860,ko01100,map00860,map01100 M00122 R05225 RC00010,RC01302 ko00000,ko00001,ko00002,ko01000 - - - AAA_26,Aminotran_1_2,CbiA,GATase_3,TP_methylase k59_1549254_1 95619.PM1_0226620 3.99e-24 98.6 COG2805@1|root,COG2805@2|Bacteria,1MU3J@1224|Proteobacteria,1RN8G@1236|Gammaproteobacteria 1236|Gammaproteobacteria NU twitching motility protein pilT GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - ko:K02669 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE k59_1549254_2 587753.EY04_31430 2.35e-46 156.0 COG0325@1|root,COG0325@2|Bacteria,1MWN7@1224|Proteobacteria,1RNPM@1236|Gammaproteobacteria 1236|Gammaproteobacteria E Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis yggS - - ko:K06997 - - - - ko00000 - - - Ala_racemase_N k59_1041483_2 1322246.BN4_11556 4.53e-32 126.0 COG3968@1|root,COG3968@2|Bacteria,1QUKF@1224|Proteobacteria,42PBH@68525|delta/epsilon subdivisions,2WJZG@28221|Deltaproteobacteria,2M9AA@213115|Desulfovibrionales 28221|Deltaproteobacteria S Glutamine synthetase, catalytic region glnN - 6.3.1.2 ko:K01915 ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 - R00253 RC00010,RC02798 ko00000,ko00001,ko01000,ko04147 - - - GSIII_N,Gln-synt_C k59_1321986_2 316275.VSAL_II0879 2.51e-09 58.2 COG0520@1|root,COG0520@2|Bacteria,1MUPD@1224|Proteobacteria,1RNIY@1236|Gammaproteobacteria,1XSAY@135623|Vibrionales 135623|Vibrionales E COG0520 Selenocysteine lyase - - - - - - - - - - - - Aminotran_5 k59_200020_1 697282.Mettu_3571 2.46e-101 314.0 COG3829@1|root,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria,1T3FK@1236|Gammaproteobacteria,1XEGV@135618|Methylococcales 135618|Methylococcales K Transcriptional regulator - - - - - - - - - - - - HTH_8,Sigma54_activat k59_932728_1 644282.Deba_1853 5.08e-19 91.3 COG0507@1|root,COG1796@1|root,COG0507@2|Bacteria,COG1796@2|Bacteria,1MW43@1224|Proteobacteria,42M8J@68525|delta/epsilon subdivisions,2WJD6@28221|Deltaproteobacteria 28221|Deltaproteobacteria L DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity recD2 - 3.1.11.5 ko:K03581 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - AAA_30,HHH_4,HHH_5,UvrD_C_2 k59_1328258_1 1454004.AW11_01987 6.58e-36 133.0 COG5473@1|root,COG5473@2|Bacteria,1N9UJ@1224|Proteobacteria,2VNM5@28216|Betaproteobacteria,1KQZ5@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria - - - - - - - - - - - - - - - k59_1160765_1 1249627.D779_4127 2.62e-97 289.0 COG4149@1|root,COG4149@2|Bacteria,1MUXR@1224|Proteobacteria,1RRDV@1236|Gammaproteobacteria,1WWGA@135613|Chromatiales 135613|Chromatiales P TIGRFAM Molybdate ABC transporter - - - ko:K02018 ko02010,map02010 M00189 - - ko00000,ko00001,ko00002,ko02000 3.A.1.8 - - BPD_transp_1 k59_1559135_1 215803.DB30_4336 3.38e-12 72.0 COG0737@1|root,COG0737@2|Bacteria,1MX03@1224|Proteobacteria,42Q71@68525|delta/epsilon subdivisions,2WK8Q@28221|Deltaproteobacteria,2YWPG@29|Myxococcales 28221|Deltaproteobacteria F 5'-nucleotidase, C-terminal domain - - 3.1.3.5,3.6.1.45 ko:K11751 ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110 - R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346 RC00017 ko00000,ko00001,ko01000 - - - 5_nucleotid_C,EF-hand_5,Metallophos k59_372425_1 1134474.O59_002097 5.24e-65 208.0 COG0796@1|root,COG0796@2|Bacteria,1NAI2@1224|Proteobacteria,1RPU9@1236|Gammaproteobacteria,1FG3U@10|Cellvibrio 1236|Gammaproteobacteria M Provides the (R)-glutamate required for cell wall biosynthesis murI GO:0000270,GO:0003674,GO:0003824,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008881,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016853,GO:0016854,GO:0016855,GO:0030203,GO:0034645,GO:0036361,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0047661,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 5.1.1.3 ko:K01776 ko00471,ko01100,map00471,map01100 - R00260 RC00302 ko00000,ko00001,ko01000,ko01011 - - iAPECO1_1312.APECO1_2496,iEC042_1314.EC042_4342,iECOK1_1307.ECOK1_4443,iECS88_1305.ECS88_4426,iPC815.YPO3909,iUMN146_1321.UM146_20110,iUTI89_1310.UTI89_C4562 Asp_Glu_race k59_1668309_1 1469613.JT55_01265 1.24e-120 356.0 COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,2TS1R@28211|Alphaproteobacteria 28211|Alphaproteobacteria I Belongs to the thiolase family - - 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N k59_143965_1 1122137.AQXF01000001_gene3396 5.32e-79 244.0 COG0524@1|root,COG0524@2|Bacteria,1MUUC@1224|Proteobacteria,2TS9D@28211|Alphaproteobacteria 28211|Alphaproteobacteria G COG0524 Sugar kinases, ribokinase family pfkB - 2.7.1.20,2.7.1.4 ko:K00847,ko:K00856 ko00051,ko00230,ko00500,ko00520,ko01100,map00051,map00230,map00500,map00520,map01100 - R00185,R00760,R00867,R03920 RC00002,RC00017 ko00000,ko00001,ko01000 - - - PfkB k59_1218228_2 525897.Dbac_2051 1.77e-45 149.0 COG0346@1|root,COG0346@2|Bacteria,1N116@1224|Proteobacteria,42SZW@68525|delta/epsilon subdivisions,2WPFI@28221|Deltaproteobacteria,2MDJD@213115|Desulfovibrionales 28221|Deltaproteobacteria E PFAM Glyoxalase bleomycin resistance protein dioxygenase - - - ko:K07032 - - - - ko00000 - - - Glyoxalase k59_315747_1 675812.VHA_002641 8.89e-93 279.0 COG0022@1|root,COG0022@2|Bacteria,1R8KB@1224|Proteobacteria,1RP3G@1236|Gammaproteobacteria,1XZWA@135623|Vibrionales 135623|Vibrionales C Transketolase, pyrimidine binding domain - - - ko:K21417 - - - - ko00000,ko01000 - - - Transket_pyr,Transketolase_C k59_1726201_1 96561.Dole_0471 3.6e-14 66.2 COG0254@1|root,COG0254@2|Bacteria,1PT0H@1224|Proteobacteria,42V2Z@68525|delta/epsilon subdivisions,2WRGA@28221|Deltaproteobacteria,2MM5X@213118|Desulfobacterales 28221|Deltaproteobacteria J Binds the 23S rRNA rpmE - - ko:K02909 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L31 k59_1726201_2 1307759.JOMJ01000003_gene393 1.61e-14 75.1 COG0216@1|root,COG0216@2|Bacteria,1MV28@1224|Proteobacteria,42NA3@68525|delta/epsilon subdivisions,2WIQU@28221|Deltaproteobacteria,2M8U2@213115|Desulfovibrionales 28221|Deltaproteobacteria J Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA prfA - - ko:K02835 - - - - ko00000,ko03012 - - - PCRF,RF-1 k59_1102605_1 702113.PP1Y_AT11795 6.41e-65 212.0 COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2TQR1@28211|Alphaproteobacteria,2JZVD@204457|Sphingomonadales 204457|Sphingomonadales C belongs to the aldehyde dehydrogenase family - - 1.2.1.16,1.2.1.20,1.2.1.79 ko:K00135 ko00250,ko00310,ko00350,ko00650,ko00760,ko01100,ko01120,map00250,map00310,map00350,map00650,map00760,map01100,map01120 M00027 R00713,R00714,R02401 RC00080 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_1050031_1 1384054.N790_02840 1.28e-82 266.0 COG2010@1|root,COG2010@2|Bacteria,1N3PN@1224|Proteobacteria,1RNS0@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Nitrite reductase nirS - 1.7.2.1,1.7.99.1 ko:K15864 ko00910,ko01120,map00910,map01120 M00529 R00143,R00783,R00785 RC00086,RC02797 ko00000,ko00001,ko00002,ko01000 - - - Cytochrom_D1,Cytochrome_CBB3 k59_480496_1 247634.GPB2148_3505 4.95e-102 309.0 COG0057@1|root,COG0057@2|Bacteria,1MZE4@1224|Proteobacteria,1RMSI@1236|Gammaproteobacteria,1J56H@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Belongs to the glyceraldehyde-3-phosphate dehydrogenase family gap - 1.2.1.12 ko:K00134 ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01061 RC00149 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - Gp_dh_C,Gp_dh_N k59_1102606_1 1174528.JH992893_gene5704 3.53e-56 192.0 COG1861@1|root,COG1861@2|Bacteria,1G3T7@1117|Cyanobacteria 1117|Cyanobacteria L Transposase DDE domain group 1 - - - - - - - - - - - - DDE_Tnp_1_4 k59_32830_5 994479.GL877878_gene3333 1.98e-06 57.0 2C8MZ@1|root,2ZA7T@2|Bacteria,2I7QK@201174|Actinobacteria,4E90Z@85010|Pseudonocardiales 201174|Actinobacteria S Family of unknown function (DUF5309) - - - - - - - - - - - - DUF5309 k59_710347_2 1123261.AXDW01000015_gene3481 3.59e-30 120.0 COG0508@1|root,COG0508@2|Bacteria,1MU7K@1224|Proteobacteria,1RMJR@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex bkdB - 2.3.1.168 ko:K09699 ko00280,ko00640,ko01100,ko01110,ko01130,map00280,map00640,map01100,map01110,map01130 M00036 R02662,R03174,R04097,R10998 RC00004,RC02727,RC02870 br01601,ko00000,ko00001,ko00002,ko01000 - - - 2-oxoacid_dh,Biotin_lipoyl,E3_binding k59_1218238_1 1537715.JQFJ01000005_gene70 1.91e-94 300.0 COG4774@1|root,COG4774@2|Bacteria,1MV0X@1224|Proteobacteria,2TTQD@28211|Alphaproteobacteria,2JZZI@204457|Sphingomonadales 204457|Sphingomonadales P receptor - - - - - - - - - - - - Plug,TonB_dep_Rec k59_257739_1 1380391.JIAS01000018_gene838 2.39e-96 292.0 COG4671@1|root,COG4671@2|Bacteria,1N1PQ@1224|Proteobacteria,2TSTV@28211|Alphaproteobacteria,2JRG0@204441|Rhodospirillales 204441|Rhodospirillales S Glycosyltransferase family 28 C-terminal domain - - - - - - - - - - - - Glyco_tran_28_C k59_650359_2 639030.JHVA01000001_gene2032 1.83e-18 82.4 COG0745@1|root,COG0745@2|Bacteria,3Y4IJ@57723|Acidobacteria,2JJIF@204432|Acidobacteriia 204432|Acidobacteriia K PFAM response regulator receiver - - - ko:K07662 ko01503,ko02020,map01503,map02020 M00447,M00727,M00728 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Trans_reg_C k59_762811_1 1219065.VPR01S_21_00610 6.18e-07 53.9 COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,1RN9T@1236|Gammaproteobacteria,1XTPV@135623|Vibrionales 135623|Vibrionales O COG0265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain degS - - ko:K04691 - - - - ko00000,ko01000,ko01002 - - - PDZ_2,Trypsin_2 k59_820433_1 314287.GB2207_02810 5.69e-100 294.0 COG0740@1|root,COG0740@2|Bacteria,1MV46@1224|Proteobacteria,1RNR6@1236|Gammaproteobacteria,1J4TT@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins clpP GO:0000502,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006515,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0009056,GO:0009057,GO:0009266,GO:0009314,GO:0009376,GO:0009408,GO:0009628,GO:0009987,GO:0010498,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017171,GO:0019538,GO:0019899,GO:0030163,GO:0031597,GO:0032991,GO:0042623,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0050896,GO:0051117,GO:0051603,GO:0070011,GO:0071704,GO:0140096,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1904949,GO:1905368,GO:1905369 3.4.21.92 ko:K01358 ko04112,ko04212,map04112,map04212 - - - ko00000,ko00001,ko01000,ko01002 - - - CLP_protease k59_932763_1 1121861.KB899915_gene1903 5.44e-70 219.0 COG1028@1|root,COG1028@2|Bacteria,1NBB6@1224|Proteobacteria,2TVF5@28211|Alphaproteobacteria 28211|Alphaproteobacteria IQ Short-chain dehydrogenase reductase sdr - - - - - - - - - - - - adh_short_C2 k59_1218243_1 498211.CJA_1029 9.34e-82 246.0 COG0817@1|root,COG0817@2|Bacteria,1MUJI@1224|Proteobacteria,1RQPJ@1236|Gammaproteobacteria,1FG9C@10|Cellvibrio 1236|Gammaproteobacteria L Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group ruvC GO:0000725,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008821,GO:0009058,GO:0009059,GO:0009314,GO:0009628,GO:0009987,GO:0016787,GO:0016788,GO:0016889,GO:0016894,GO:0031297,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0045005,GO:0046483,GO:0048476,GO:0050896,GO:0051716,GO:0071704,GO:0071932,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901576 3.1.22.4 ko:K01159 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - RuvC k59_1160807_3 472759.Nhal_1234 1.47e-177 506.0 COG0821@1|root,COG0821@2|Bacteria,1MUAX@1224|Proteobacteria,1RMXZ@1236|Gammaproteobacteria,1WW8H@135613|Chromatiales 135613|Chromatiales I Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate ispG - 1.17.7.1,1.17.7.3 ko:K03526 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R08689,R10859 RC01486 ko00000,ko00001,ko00002,ko01000 - - - GcpE k59_1502179_1 62928.azo3553 2.73e-45 157.0 COG1120@1|root,COG1120@2|Bacteria,1MUNG@1224|Proteobacteria,2VRFJ@28216|Betaproteobacteria,2KW3Z@206389|Rhodocyclales 206389|Rhodocyclales HP COG1120 ABC-type cobalamin Fe3 -siderophores transport systems, ATPase components - - 3.6.3.34 ko:K02013 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.14 - - ABC_tran k59_1668357_1 515620.EUBELI_02060 7.2e-30 115.0 COG2197@1|root,COG2197@2|Bacteria,1TRXG@1239|Firmicutes,24FZX@186801|Clostridia,25ZQZ@186806|Eubacteriaceae 186801|Clostridia K helix_turn_helix, Lux Regulon degU - - - - - - - - - - - GerE,Response_reg k59_535791_1 521719.ATXQ01000011_gene154 2.55e-33 123.0 COG1392@1|root,COG1392@2|Bacteria,1MXY9@1224|Proteobacteria,1RQHT@1236|Gammaproteobacteria,1YDJU@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria P Protein of unknown function DUF47 UF78_21250 - - ko:K07220 - - - - ko00000 - - - PhoU_div k59_535791_2 670487.Ocepr_0891 3.29e-15 70.9 COG2947@1|root,COG2947@2|Bacteria,1WJVZ@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus S COGs COG2947 conserved - - - - - - - - - - - - EVE k59_597209_2 861299.J421_1582 1.85e-10 62.4 2ETJB@1|root,33M34@2|Bacteria 2|Bacteria S Domain of unknown function (DUF4345) - - - - - - - - - - - - DUF4345 k59_257773_1 59196.RICGR_0849 7.5e-29 112.0 COG2917@1|root,COG2917@2|Bacteria,1NWIZ@1224|Proteobacteria,1RQAB@1236|Gammaproteobacteria,1JC9T@118969|Legionellales 118969|Legionellales D probably involved in intracellular septation yciB - - ko:K06190 - - - - ko00000 - - - IspA k59_1559216_1 436308.Nmar_0582 2.76e-40 142.0 COG0150@1|root,arCOG00639@2157|Archaea,41SEE@651137|Thaumarchaeota 651137|Thaumarchaeota F Phosphoribosylformylglycinamidine cyclo-ligase purM - 6.3.3.1 ko:K01933 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04208 RC01100 ko00000,ko00001,ko00002,ko01000 - - - AIRS,AIRS_C k59_1559216_2 1229909.NSED_03055 1.8e-99 299.0 COG0475@1|root,arCOG01953@2157|Archaea,41T00@651137|Thaumarchaeota 651137|Thaumarchaeota P Sodium hydrogen exchanger - - - - - - - - - - - - Na_H_Exchanger k59_1502196_1 272134.KB731324_gene1322 3.04e-73 233.0 COG0489@1|root,COG0489@2|Bacteria,1G1I7@1117|Cyanobacteria,1H81K@1150|Oscillatoriales 1117|Cyanobacteria D Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP mrp - - ko:K03593 - - - - ko00000,ko03029,ko03036 - - - FeS_assembly_P,ParA k59_1218263_1 1232410.KI421422_gene2042 8.37e-84 255.0 COG1475@1|root,COG1475@2|Bacteria,1MW2E@1224|Proteobacteria,42M8S@68525|delta/epsilon subdivisions,2WNG8@28221|Deltaproteobacteria,43S4I@69541|Desulfuromonadales 28221|Deltaproteobacteria K ParB-like nuclease domain parB - - ko:K03497 - - - - ko00000,ko03000,ko03036,ko04812 - - - ParBc k59_89612_1 864051.BurJ1DRAFT_1514 3.59e-13 74.7 COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria,1KJDR@119065|unclassified Burkholderiales 28216|Betaproteobacteria T Diguanylate cyclase - - - - - - - - - - - - EAL,GGDEF,HAMP k59_1668935_1 272123.Anacy_5459 4.79e-28 118.0 COG1020@1|root,COG1020@2|Bacteria,1G0XE@1117|Cyanobacteria,1HKNU@1161|Nostocales 1117|Cyanobacteria Q TIGRFAM amino acid adenylation domain - - - - - - - - - - - - AMP-binding,AMP-binding_C,Condensation,PP-binding k59_1441693_1 78245.Xaut_4003 2.95e-22 97.4 COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,2TSGZ@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Transposase (IS116 IS110 IS902 family) - - - - - - - - - - - - DEDD_Tnp_IS110,Transposase_20 k59_1779253_1 1266908.AQPB01000017_gene19 5.7e-39 130.0 2DNRM@1|root,32YT2@2|Bacteria,1N8BS@1224|Proteobacteria,1T0VB@1236|Gammaproteobacteria,1WZ7K@135613|Chromatiales 135613|Chromatiales S Protein of unknown function (DUF2442) - - - - - - - - - - - - DUF2442 k59_711189_1 1415778.JQMM01000001_gene1148 1.19e-92 281.0 COG0714@1|root,COG0714@2|Bacteria,1QDUZ@1224|Proteobacteria,1RQGT@1236|Gammaproteobacteria,1J53R@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S AAA domain (dynein-related subfamily) yehL - - - - - - - - - - - AAA_5 k59_1668941_1 658187.LDG_7605 4.24e-24 98.6 COG3228@1|root,COG3228@2|Bacteria,1RAHF@1224|Proteobacteria,1RZQU@1236|Gammaproteobacteria,1JDG6@118969|Legionellales 118969|Legionellales S Glucose-regulated metallo-peptidase M90 mtfA - - ko:K09933 - - - - ko00000,ko01002 - - - Peptidase_M90 k59_933344_1 467661.RKLH11_56 6.45e-49 171.0 COG1964@1|root,COG1964@2|Bacteria,1R0G9@1224|Proteobacteria,2U3YW@28211|Alphaproteobacteria 28211|Alphaproteobacteria S 4Fe-4S single cluster domain - - - - - - - - - - - - Fer4_12,Radical_SAM k59_425562_1 1096930.L284_20540 3.93e-56 191.0 COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2TRP2@28211|Alphaproteobacteria,2K0DK@204457|Sphingomonadales 204457|Sphingomonadales IQ COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II - - - - - - - - - - - - AMP-binding,AMP-binding_C k59_1779263_1 909663.KI867150_gene109 8.19e-91 294.0 COG1148@1|root,COG1148@2|Bacteria,1QUM4@1224|Proteobacteria,42MPP@68525|delta/epsilon subdivisions,2WJ3U@28221|Deltaproteobacteria,2MQTI@213462|Syntrophobacterales 28221|Deltaproteobacteria C Pyridine nucleotide-disulphide oxidoreductase - - 1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6 ko:K03388 ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200 M00356,M00357,M00563,M00567 R04540,R11928,R11931,R11943,R11944 RC00011 ko00000,ko00001,ko00002,ko01000 - - - Fer4,Fer4_4,Fer4_7,NAD_binding_8,Pyr_redox_2 k59_200896_1 765914.ThisiDRAFT_1911 9.99e-19 82.0 COG2891@1|root,COG2891@2|Bacteria,1RER7@1224|Proteobacteria,1S8VI@1236|Gammaproteobacteria,1WYH2@135613|Chromatiales 135613|Chromatiales M Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins - - - ko:K03571 - - - - ko00000,ko03036 9.B.157.1 - - MreD k59_200896_2 697282.Mettu_1391 2.58e-48 165.0 COG1792@1|root,COG1792@2|Bacteria,1N8ZS@1224|Proteobacteria,1RMK4@1236|Gammaproteobacteria,1XECP@135618|Methylococcales 135618|Methylococcales M Involved in formation and maintenance of cell shape mreC - - ko:K03570 - - - - ko00000,ko03036 9.B.157.1 - - MreC k59_1389847_1 675813.VIB_002136 9.04e-122 377.0 COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,1RMS9@1236|Gammaproteobacteria,1XSPJ@135623|Vibrionales 135623|Vibrionales L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate uvrA GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009380,GO:0009381,GO:0009987,GO:0016787,GO:0016788,GO:0032991,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1902494,GO:1905347,GO:1905348,GO:1990391 - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - ABC_tran k59_1614189_1 999550.KI421507_gene3524 9.63e-15 75.1 COG4221@1|root,COG4221@2|Bacteria,1MUF8@1224|Proteobacteria,2TUSA@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Belongs to the short-chain dehydrogenases reductases (SDR) family - - - - - - - - - - - - adh_short k59_989063_1 240292.Ava_1613 1.6e-42 159.0 COG1020@1|root,COG1020@2|Bacteria,1G0XE@1117|Cyanobacteria,1HRK2@1161|Nostocales 1117|Cyanobacteria Q Pfam:HxxPF_rpt - - - - - - - - - - - - AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase k59_144508_1 316407.85675207 2.73e-110 334.0 COG4248@1|root,COG4248@2|Bacteria,1MWZX@1224|Proteobacteria,1S1BZ@1236|Gammaproteobacteria,3XQX7@561|Escherichia 1236|Gammaproteobacteria S protein kinase activity yegI - - - - - - - - - - - Pkinase k59_598046_1 1415778.JQMM01000001_gene23 1.56e-86 271.0 COG0442@1|root,COG0442@2|Bacteria,1MU7E@1224|Proteobacteria,1RN5R@1236|Gammaproteobacteria,1J4UV@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS proS GO:0002161,GO:0003674,GO:0003824,GO:0004812,GO:0004827,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006433,GO:0006450,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0043906,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.15 ko:K01881 ko00970,map00970 M00359,M00360 R03661 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iUTI89_1310.UTI89_C0210 HGTP_anticodon,tRNA-synt_2b,tRNA_edit k59_1726803_1 1288494.EBAPG3_28130 4.87e-105 314.0 COG0849@1|root,COG0849@2|Bacteria,1MUSR@1224|Proteobacteria,2VGZP@28216|Betaproteobacteria,372QQ@32003|Nitrosomonadales 28216|Betaproteobacteria D Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring ftsA - - ko:K03590 ko04112,map04112 - - - ko00000,ko00001,ko03036,ko04812 - - - FtsA,SHS2_FTSA k59_90130_1 28258.KP05_05180 3.8e-11 63.2 COG0534@1|root,COG0534@2|Bacteria,1MV6B@1224|Proteobacteria,1RPGF@1236|Gammaproteobacteria,1XI5B@135619|Oceanospirillales 135619|Oceanospirillales V MATE efflux family protein - - - ko:K03327 - - - - ko00000,ko02000 2.A.66.1 - - MatE k59_90130_2 666685.R2APBS1_1272 1.26e-84 261.0 COG1960@1|root,COG1960@2|Bacteria,1MUK0@1224|Proteobacteria,1RNBX@1236|Gammaproteobacteria,1X45S@135614|Xanthomonadales 135614|Xanthomonadales I Acyl-CoA dehydrogenase gcdH - 1.3.8.6 ko:K00252 ko00071,ko00310,ko00362,ko00380,ko01100,ko01120,ko01130,map00071,map00310,map00362,map00380,map01100,map01120,map01130 M00032 R02487,R02488,R10074 RC00052,RC00156 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_711231_1 314260.PB2503_10509 3.58e-43 150.0 COG1596@1|root,COG1596@2|Bacteria,1RFBH@1224|Proteobacteria,2U835@28211|Alphaproteobacteria 28211|Alphaproteobacteria M polysaccharide export - - - ko:K01991 ko02026,map02026 - - - ko00000,ko00001,ko02000 1.B.18 - - Poly_export,SLBB k59_316674_1 313603.FB2170_01607 4.82e-112 344.0 COG3459@1|root,COG3459@2|Bacteria,4NIVN@976|Bacteroidetes,1I07E@117743|Flavobacteriia 976|Bacteroidetes G Putative carbohydrate binding domain cepA - 2.4.1.20 ko:K00702 ko00500,ko01100,map00500,map01100 - R00952 RC00049 ko00000,ko00001,ko01000 - GT36 - Glyco_hydro_36,Glyco_transf_36,Glycoamylase k59_200925_1 316407.85676681 3.02e-161 458.0 COG4992@1|root,COG4992@2|Bacteria,1MV3C@1224|Proteobacteria,1RMV1@1236|Gammaproteobacteria,3XPBV@561|Escherichia 1236|Gammaproteobacteria E Involved in both the arginine and lysine biosynthetic pathways argD GO:0003674,GO:0003824,GO:0003992,GO:0004069,GO:0005488,GO:0005515,GO:0006082,GO:0006105,GO:0006520,GO:0006525,GO:0006526,GO:0006527,GO:0006553,GO:0006591,GO:0006593,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009016,GO:0009056,GO:0009058,GO:0009063,GO:0009064,GO:0009065,GO:0009066,GO:0009067,GO:0009084,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016054,GO:0016740,GO:0016769,GO:0017144,GO:0019545,GO:0019752,GO:0019842,GO:0030170,GO:0033359,GO:0036094,GO:0042450,GO:0042802,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0043825,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044281,GO:0044282,GO:0044283,GO:0046394,GO:0046395,GO:0046451,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1901607 2.6.1.11,2.6.1.17,2.6.1.81 ko:K00821,ko:K00840 ko00220,ko00300,ko00330,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map00330,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00028,M00845 R02283,R04217,R04475 RC00006,RC00062 ko00000,ko00001,ko00002,ko01000,ko01007 - - iEC55989_1330.EC55989_1916,iSFV_1184.SFV_3365,iSF_1195.SF3378,iSFxv_1172.SFxv_3689,iSSON_1240.SSON_3490,iS_1188.S4385 Aminotran_3 k59_1050690_1 330214.NIDE1217 2.41e-47 165.0 COG1232@1|root,COG1232@2|Bacteria,3J0PQ@40117|Nitrospirae 40117|Nitrospirae H Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX - - 1.3.3.15,1.3.3.4 ko:K00231 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R03222,R04178 RC00885 ko00000,ko00001,ko00002,ko01000 - - - Amino_oxidase k59_1050690_2 330214.NIDE1216 6.47e-10 59.7 COG0276@1|root,COG0276@2|Bacteria,3J0P9@40117|Nitrospirae 40117|Nitrospirae H Catalyzes the ferrous insertion into protoporphyrin IX hemH - 4.99.1.1,4.99.1.9 ko:K01772 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R00310,R11329 RC01012 ko00000,ko00001,ko00002,ko01000 - - - Ferrochelatase k59_989078_1 525146.Ddes_0890 7.61e-79 252.0 COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,42N89@68525|delta/epsilon subdivisions,2WIUT@28221|Deltaproteobacteria,2M7ZS@213115|Desulfovibrionales 28221|Deltaproteobacteria M PDZ DHR GLGF domain protein - - 3.4.21.107 ko:K04771 ko01503,ko02020,map01503,map02020 M00728 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 - - - PDZ_2,Trypsin_2 k59_1050696_1 493475.GARC_2390 1.06e-28 112.0 COG2863@1|root,COG2863@2|Bacteria,1QXWH@1224|Proteobacteria,1T3IQ@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Cytochrome c - - - - - - - - - - - - Cytochrom_C,ThuA k59_1050696_2 1336233.JAEH01000006_gene2329 2.99e-13 75.5 COG1629@1|root,COG4771@2|Bacteria,1MWKN@1224|Proteobacteria,1RNZX@1236|Gammaproteobacteria,2QAXG@267890|Shewanellaceae 1236|Gammaproteobacteria M TonB dependent receptor - - - - - - - - - - - - Plug,TonB_dep_Rec k59_425595_2 1121035.AUCH01000016_gene2142 6.07e-47 156.0 2BWQ4@1|root,32QZV@2|Bacteria,1MZQ9@1224|Proteobacteria,2VSNR@28216|Betaproteobacteria,2KWKW@206389|Rhodocyclales 206389|Rhodocyclales S Domain of unknown function (DUF4124) - - - - - - - - - - - - DUF4124 k59_90149_1 1168065.DOK_18040 2.89e-60 199.0 COG0056@1|root,COG0056@2|Bacteria,1MUG7@1224|Proteobacteria,1RP4V@1236|Gammaproteobacteria,1J5DU@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit atpA GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045261,GO:0045262,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 3.6.3.14 ko:K02111 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - iSbBS512_1146.SbBS512_E4187 ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N k59_90149_2 95619.PM1_0229070 2.63e-21 88.6 COG0712@1|root,COG0712@2|Bacteria,1MVRH@1224|Proteobacteria,1S8X2@1236|Gammaproteobacteria 1236|Gammaproteobacteria C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation atpH GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0036442,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045261,GO:0045262,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0046961,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - ko:K02113 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - iSF_1195.SF3815,iSFxv_1172.SFxv_4157,iS_1188.S3953 OSCP k59_1502989_1 498211.CJA_0880 1.42e-68 219.0 COG0001@1|root,COG0001@2|Bacteria,1MUY5@1224|Proteobacteria,1RM7N@1236|Gammaproteobacteria,1FGZU@10|Cellvibrio 1236|Gammaproteobacteria H Aminotransferase class-III hemL GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006725,GO:0006778,GO:0006779,GO:0006782,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016853,GO:0016866,GO:0016869,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042286,GO:0042440,GO:0042802,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046483,GO:0046501,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 5.4.3.8 ko:K01845 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R02272 RC00677 ko00000,ko00001,ko00002,ko01000,ko01007 - - iUMNK88_1353.UMNK88_158 Aminotran_3 k59_721255_1 945713.IALB_0230 3.42e-37 139.0 COG1232@1|root,COG1232@2|Bacteria 2|Bacteria H protoporphyrinogen oxidase activity hemG - 1.14.19.9,1.3.3.15,1.3.3.4 ko:K00231,ko:K14266 ko00404,ko00860,ko01100,ko01110,ko01130,map00404,map00860,map01100,map01110,map01130 M00121,M00789,M00790 R03222,R04178,R09570 RC00885,RC00949 ko00000,ko00001,ko00002,ko01000 - - iSB619.SA_RS09325 Amino_oxidase k59_1735315_1 1201293.AKXQ01000009_gene939 2.79e-74 231.0 COG0697@1|root,COG0697@2|Bacteria,1MXJ6@1224|Proteobacteria,1RSIB@1236|Gammaproteobacteria 1236|Gammaproteobacteria EG COG0697 Permeases of the drug metabolite transporter (DMT) superfamily - - - - - - - - - - - - EamA k59_1512463_1 1279017.AQYJ01000020_gene1236 3.16e-102 299.0 COG0512@1|root,COG0512@2|Bacteria,1MV5Y@1224|Proteobacteria,1RMQW@1236|Gammaproteobacteria,4641F@72275|Alteromonadaceae 1236|Gammaproteobacteria EH COG0512 Anthranilate para-aminobenzoate synthases component II pabA GO:0000162,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005950,GO:0006082,GO:0006520,GO:0006568,GO:0006575,GO:0006576,GO:0006586,GO:0006725,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009108,GO:0009308,GO:0009309,GO:0009396,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0018130,GO:0019438,GO:0019752,GO:0032991,GO:0034641,GO:0042398,GO:0042401,GO:0042430,GO:0042435,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0046653,GO:0046654,GO:0046820,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494 2.6.1.85,4.1.3.27 ko:K01658,ko:K01664 ko00400,ko00405,ko00790,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map00790,map01100,map01110,map01130,map01230,map02024,map02025 M00023 R00985,R00986,R01716 RC00010,RC01418,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 - - iAPECO1_1312.APECO1_3095,iEC042_1314.EC042_3623,iECABU_c1320.ECABU_c37840,iECED1_1282.ECED1_4024,iECNA114_1301.ECNA114_3463,iECOK1_1307.ECOK1_3780,iECP_1309.ECP_3451,iECS88_1305.ECS88_3751,iECSF_1327.ECSF_3187,iLF82_1304.LF82_1586,iNRG857_1313.NRG857_16660,iUMN146_1321.UM146_16880,iUTI89_1310.UTI89_C3863,ic_1306.c4135 GATase k59_942229_1 518766.Rmar_2770 5.37e-28 114.0 COG1975@1|root,COG2608@1|root,COG1975@2|Bacteria,COG2608@2|Bacteria,4NP35@976|Bacteroidetes 976|Bacteroidetes O COGs COG1975 Xanthine and CO dehydrogenase maturation factor XdhC CoxF family - - - ko:K07402 - - - - ko00000 - - - XdhC_C,XdhC_CoxI,YHS k59_326406_1 551789.ATVJ01000001_gene1061 1.57e-38 133.0 COG1522@1|root,COG1522@2|Bacteria,1RIZA@1224|Proteobacteria,2UBJK@28211|Alphaproteobacteria,43ZY9@69657|Hyphomonadaceae 28211|Alphaproteobacteria K helix_turn_helix ASNC type - - - ko:K05800 - - - - ko00000,ko03000 - - - AsnC_trans_reg,HTH_24,HTH_AsnC-type k59_830930_1 1049564.TevJSym_bb00050 2.46e-48 172.0 COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,1NBSJ@1224|Proteobacteria,1S0WV@1236|Gammaproteobacteria,1J5KF@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Pyruvate ferredoxin oxidoreductase and related 2-oxoacid ferredoxin oxidoreductases korA - 1.2.7.11,1.2.7.3 ko:K00174 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - PFOR_II,POR,POR_N k59_830930_2 1187851.A33M_4208 1.17e-199 567.0 COG0493@1|root,COG0493@2|Bacteria,1MU2H@1224|Proteobacteria,2TSE2@28211|Alphaproteobacteria,3FCY5@34008|Rhodovulum 28211|Alphaproteobacteria E Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster - - - - - - - - - - - - DHODB_Fe-S_bind,Fer4_20,Pyr_redox_2 k59_268357_1 1229780.BN381_80393 7.51e-74 232.0 COG2267@1|root,COG2267@2|Bacteria,2I94I@201174|Actinobacteria 201174|Actinobacteria I Alpha beta hydrolase - - - - - - - - - - - - Abhydrolase_1,Abhydrolase_6 k59_998199_1 1144305.PMI02_02527 1.21e-79 246.0 COG0115@1|root,COG0115@2|Bacteria,1MVB0@1224|Proteobacteria,2TR1H@28211|Alphaproteobacteria,2K0G3@204457|Sphingomonadales 204457|Sphingomonadales E Branched-chain amino acid aminotransferase ilvE - 2.6.1.42 ko:K00826 ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00036,M00119,M00570 R01090,R01214,R02199,R10991 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_4 k59_607948_1 1286632.P278_18570 1.11e-58 184.0 COG0432@1|root,COG0432@2|Bacteria,4NNMN@976|Bacteroidetes,1I21B@117743|Flavobacteriia 976|Bacteroidetes S Uncharacterised protein family UPF0047 yjbQ - - - - - - - - - - - UPF0047 k59_607948_2 1197477.IA57_00705 6.22e-79 244.0 2CD20@1|root,2Z7SQ@2|Bacteria,4NEQ1@976|Bacteroidetes,1HXI3@117743|Flavobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_660509_1 158500.BV97_05046 1.16e-115 343.0 COG2723@1|root,COG2723@2|Bacteria,1MWG6@1224|Proteobacteria,2TSRN@28211|Alphaproteobacteria,2K1C4@204457|Sphingomonadales 204457|Sphingomonadales G Belongs to the glycosyl hydrolase 1 family - - 3.2.1.21 ko:K05350 ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110 - R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040 RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248 ko00000,ko00001,ko01000 - - - Glyco_hydro_1 k59_268358_1 1123279.ATUS01000001_gene1147 2.69e-14 72.0 COG0575@1|root,COG0575@2|Bacteria,1MWSV@1224|Proteobacteria,1RQ6M@1236|Gammaproteobacteria,1J5Q2@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria I Belongs to the CDS family cdsA GO:0003674,GO:0003824,GO:0004605,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006220,GO:0006221,GO:0006629,GO:0006644,GO:0006650,GO:0006655,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009117,GO:0009165,GO:0009987,GO:0016020,GO:0016024,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044271,GO:0044281,GO:0044464,GO:0045017,GO:0046341,GO:0046471,GO:0046474,GO:0046483,GO:0046486,GO:0055086,GO:0070567,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.7.41 ko:K00981 ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070 M00093 R01799 RC00002 ko00000,ko00001,ko00002,ko01000 - - iJN746.PP_1596,iSDY_1059.SDY_0191 CTP_transf_1 k59_268358_2 1168065.DOK_07319 9.07e-35 126.0 COG0020@1|root,COG0020@2|Bacteria,1MVP1@1224|Proteobacteria,1RMVX@1236|Gammaproteobacteria,1J5QE@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with (2E,6E)-farnesyl diphosphate (E,E-FPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E,38E)-undecaprenyl diphosphate (di-trans,octa-cis-UPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide uppS GO:0000270,GO:0000287,GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006022,GO:0006023,GO:0006024,GO:0006066,GO:0006629,GO:0006720,GO:0006807,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008834,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0030203,GO:0034645,GO:0042546,GO:0043164,GO:0043167,GO:0043169,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0046872,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617 2.5.1.31 ko:K00806 ko00900,ko01110,map00900,map01110 - R06447 RC00279,RC02839 ko00000,ko00001,ko01000,ko01006 - - iECBD_1354.ECBD_3445,iECOK1_1307.ECOK1_0175,iECSE_1348.ECSE_0173,iECW_1372.ECW_m0170,iEKO11_1354.EKO11_3744,iEcDH1_1363.EcDH1_3429,iEcE24377_1341.EcE24377A_0178,iEcHS_1320.EcHS_A0176,iNRG857_1313.NRG857_00890,iSFV_1184.SFV_0157,iUMN146_1321.UM146_23675,iUMNK88_1353.UMNK88_178,iWFL_1372.ECW_m0170,iY75_1357.Y75_RS00880 Prenyltransf k59_1399847_1 861299.J421_1936 1.56e-23 102.0 COG3158@1|root,COG3158@2|Bacteria,1ZTCK@142182|Gemmatimonadetes 2|Bacteria P Transport of potassium into the cell kup - - ko:K03549 - - - - ko00000,ko02000 2.A.72 - - K_trans k59_1787474_1 1122137.AQXF01000001_gene3019 7.23e-282 786.0 COG1185@1|root,COG1185@2|Bacteria,1MVB9@1224|Proteobacteria,2TRH3@28211|Alphaproteobacteria 28211|Alphaproteobacteria J Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction pnp GO:0000175,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004518,GO:0004527,GO:0004532,GO:0004540,GO:0004654,GO:0005488,GO:0006139,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008408,GO:0009056,GO:0009057,GO:0009892,GO:0009987,GO:0010468,GO:0010605,GO:0010629,GO:0016070,GO:0016071,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016796,GO:0016896,GO:0019222,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0060255,GO:0065007,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0097159,GO:0140098,GO:1901360,GO:1901361,GO:1901363,GO:1901575 2.7.7.8 ko:K00962 ko00230,ko00240,ko03018,map00230,map00240,map03018 M00394 R00437,R00438,R00439,R00440 RC02795 ko00000,ko00001,ko00002,ko01000,ko03016,ko03019 - - - KH_1,PNPase,RNase_PH,RNase_PH_C,S1 k59_891378_1 702113.PP1Y_AT30117 9.45e-47 165.0 COG0741@1|root,COG0741@2|Bacteria,1MV3F@1224|Proteobacteria,2U35U@28211|Alphaproteobacteria,2K136@204457|Sphingomonadales 204457|Sphingomonadales M COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains) - - - - - - - - - - - - SLT k59_1280902_1 1121921.KB898713_gene1773 2.62e-108 332.0 COG1185@1|root,COG1185@2|Bacteria,1MVB9@1224|Proteobacteria,1RNBF@1236|Gammaproteobacteria,2PN46@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria J KH domain pnp GO:0000166,GO:0000175,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004518,GO:0004527,GO:0004532,GO:0004540,GO:0004654,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0008408,GO:0009056,GO:0009057,GO:0009266,GO:0009408,GO:0009628,GO:0009892,GO:0009987,GO:0010468,GO:0010605,GO:0010629,GO:0016070,GO:0016071,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016796,GO:0016896,GO:0017076,GO:0019001,GO:0019222,GO:0019439,GO:0030551,GO:0032553,GO:0032555,GO:0032561,GO:0034641,GO:0034655,GO:0035438,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0050896,GO:0060255,GO:0065007,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0097159,GO:0097367,GO:0140098,GO:1901265,GO:1901360,GO:1901361,GO:1901363,GO:1901575 2.7.7.8 ko:K00962 ko00230,ko00240,ko03018,map00230,map00240,map03018 M00394 R00437,R00438,R00439,R00440 RC02795 ko00000,ko00001,ko00002,ko01000,ko03016,ko03019 - - - KH_1,PNPase,RNase_PH,RNase_PH_C,S1 k59_1677557_1 1380600.AUYN01000007_gene3070 1.15e-44 148.0 COG1664@1|root,COG1664@2|Bacteria,4NUZA@976|Bacteroidetes,1I47M@117743|Flavobacteriia 976|Bacteroidetes M Integral membrane protein CcmA involved in cell shape determination - - - - - - - - - - - - Bactofilin k59_891394_1 1242864.D187_006642 1.41e-06 55.8 COG0642@1|root,COG0745@1|root,COG0745@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,42M0Y@68525|delta/epsilon subdivisions,2X791@28221|Deltaproteobacteria 28221|Deltaproteobacteria T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - GAF_2,HATPase_c,HisKA,PAS_4,Response_reg k59_1337476_1 1415778.JQMM01000001_gene866 7.98e-98 298.0 COG0772@1|root,COG0772@2|Bacteria,1MVDB@1224|Proteobacteria,1RMIV@1236|Gammaproteobacteria,1J5FI@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Peptidoglycan polymerase that is essential for cell division ftsW GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0008360,GO:0009987,GO:0015647,GO:0015648,GO:0015835,GO:0015836,GO:0016020,GO:0016021,GO:0022603,GO:0022604,GO:0022857,GO:0022884,GO:0031224,GO:0031226,GO:0032153,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0051179,GO:0051234,GO:0051301,GO:0055085,GO:0065007,GO:0065008,GO:0071702,GO:0071705,GO:0071944,GO:1901264,GO:1901505 - ko:K03588 ko04112,map04112 - - - ko00000,ko00001,ko02000,ko03036 2.A.103.1 - - FTSW_RODA_SPOVE k59_1512499_1 1123236.KB899376_gene676 0.000455 43.9 COG3170@1|root,COG4313@1|root,COG3170@2|Bacteria,COG4313@2|Bacteria,1QUSB@1224|Proteobacteria,1T22F@1236|Gammaproteobacteria,466WB@72275|Alteromonadaceae 1236|Gammaproteobacteria CNU Putative MetA-pathway of phenol degradation - - - - - - - - - - - - Phenol_MetA_deg k59_1512499_2 1255043.TVNIR_3190 8.49e-47 168.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,1WXMC@135613|Chromatiales 135613|Chromatiales T two component, sigma54 specific, transcriptional regulator, Fis family - - - - - - - - - - - - HTH_8,Response_reg,Sigma54_activat k59_1112235_1 1122137.AQXF01000005_gene1161 2.87e-29 108.0 COG0221@1|root,COG0221@2|Bacteria,1RA2F@1224|Proteobacteria,2TQZM@28211|Alphaproteobacteria 28211|Alphaproteobacteria C Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions ppa - 3.6.1.1 ko:K01507 ko00190,map00190 - - - ko00000,ko00001,ko01000 - - - Pyrophosphatase k59_489965_1 1043493.BBLU01000004_gene2539 3.7e-68 228.0 COG1808@1|root,COG1808@2|Bacteria 2|Bacteria S Domain of unknown function (DUF389) - - - - - - - - - - - - DUF389 k59_1337486_1 1232410.KI421417_gene2753 2.01e-35 130.0 COG1877@1|root,COG1877@2|Bacteria,1PF7W@1224|Proteobacteria,42QT9@68525|delta/epsilon subdivisions,2WNR9@28221|Deltaproteobacteria,43UM2@69541|Desulfuromonadales 28221|Deltaproteobacteria G Removes the phosphate from trehalose 6-phosphate to produce free trehalose otsB - 3.1.3.12 ko:K01087 ko00500,ko01100,map00500,map01100 - R02778 RC00017 ko00000,ko00001,ko01000 - - - Trehalose_PPase k59_153356_1 1469245.JFBG01000027_gene1495 1.86e-84 266.0 COG4147@1|root,COG4147@2|Bacteria,1MVJ8@1224|Proteobacteria,1RN0R@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family actP - - ko:K14393 - - - - ko00000,ko02000 2.A.21.7 - - SSF k59_153356_2 1038859.AXAU01000005_gene5109 1.22e-06 46.6 COG4327@1|root,COG4327@2|Bacteria,1Q1GP@1224|Proteobacteria,2V981@28211|Alphaproteobacteria,3K4Z0@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S Domain of unknown function (DUF4212) - - - - - - - - - - - - DUF4212 k59_772339_1 383381.EH30_00070 1.87e-44 165.0 COG1413@1|root,COG1413@2|Bacteria,1R4FD@1224|Proteobacteria 1224|Proteobacteria C Domain of unknown function (DUF4132) - - - - - - - - - - - - DUF4132,HEAT_2 k59_772339_2 715226.ABI_24190 2.68e-66 212.0 COG0714@1|root,COG0714@2|Bacteria 2|Bacteria KLT Associated with various cellular activities yehL - - - - - - - - - - - AAA_5 k59_1171244_1 1298858.AUEL01000013_gene4974 3.31e-51 175.0 COG0579@1|root,COG0579@2|Bacteria,1N0QB@1224|Proteobacteria,2TU6K@28211|Alphaproteobacteria,43KS6@69277|Phyllobacteriaceae 28211|Alphaproteobacteria S FAD dependent oxidoreductase - - - ko:K15736 - - - - ko00000,ko01000 - - - DAO k59_43887_2 1123279.ATUS01000003_gene358 1.26e-38 142.0 COG1459@1|root,COG1459@2|Bacteria,1MV4U@1224|Proteobacteria,1RQ86@1236|Gammaproteobacteria,1J7ED@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria U COG1459 Type II secretory pathway, component PulF gspF GO:0002790,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008104,GO:0008150,GO:0009306,GO:0009987,GO:0015031,GO:0015628,GO:0015833,GO:0016020,GO:0032940,GO:0033036,GO:0042886,GO:0044464,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0098776 - ko:K02455 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - T2SSF k59_1623571_1 1189619.pgond44_11691 3.95e-05 45.1 COG3542@1|root,COG3542@2|Bacteria,4NPCH@976|Bacteroidetes,1I2JW@117743|Flavobacteriia,4C3P6@83612|Psychroflexus 976|Bacteroidetes S Cupin superfamily (DUF985) - - - ko:K09705 - - - - ko00000 - - - Cupin_5 k59_1623571_2 216432.CA2559_10683 1.16e-79 243.0 COG0413@1|root,COG0413@2|Bacteria,4NDX4@976|Bacteroidetes,1HXEE@117743|Flavobacteriia 976|Bacteroidetes H Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate panB - 2.1.2.11 ko:K00606 ko00770,ko01100,ko01110,map00770,map01100,map01110 M00119 R01226 RC00022,RC00200 ko00000,ko00001,ko00002,ko01000 - - - Pantoate_transf k59_1172240_1 1279038.KB907348_gene3134 1.85e-63 206.0 COG0116@1|root,COG0116@2|Bacteria,1MUQM@1224|Proteobacteria,2TSWI@28211|Alphaproteobacteria,2JRGX@204441|Rhodospirillales 204441|Rhodospirillales L Putative RNA methylase family UPF0020 - - - ko:K07444 - - - - ko00000,ko01000 - - - THUMP,UPF0020 k59_1513494_1 1123487.KB892856_gene2548 3.51e-65 208.0 COG0345@1|root,COG0345@2|Bacteria,1R5J1@1224|Proteobacteria,2VJD1@28216|Betaproteobacteria,2KUUS@206389|Rhodocyclales 206389|Rhodocyclales E Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline proC - 1.5.1.2 ko:K00286 ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230 M00015 R01248,R01251,R03291,R03293 RC00054,RC00083 ko00000,ko00001,ko00002,ko01000 - - - F420_oxidored,P5CR_dimer k59_383950_1 46429.BV95_00316 2.48e-136 405.0 COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,2TR2P@28211|Alphaproteobacteria,2K9KM@204457|Sphingomonadales 204457|Sphingomonadales V AAA domain, putative AbiEii toxin, Type IV TA system - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_327368_1 888832.HMPREF9420_0635 1.66e-12 73.9 COG0635@1|root,COG0635@2|Bacteria,4NFEE@976|Bacteroidetes,2FPFC@200643|Bacteroidia 976|Bacteroidetes H Involved in the biosynthesis of porphyrin-containing compound hemN - - - - - - - - - - - HemN_C,Radical_SAM k59_1451842_1 436308.Nmar_0081 5.06e-77 236.0 COG2138@1|root,arCOG02246@2157|Archaea,41SH6@651137|Thaumarchaeota 651137|Thaumarchaeota P Cobalt chelatase (CbiK) - - 5.4.99.60,5.4.99.61 ko:K06042 ko00860,ko01100,map00860,map01100 - R05177,R05814 RC01292,RC01980 ko00000,ko00001,ko01000 - - - CbiX k59_1451842_2 1229909.NSED_00105 1.51e-16 77.8 COG2073@1|root,arCOG00651@2157|Archaea,41S83@651137|Thaumarchaeota 651137|Thaumarchaeota H Cobalamin synthesis G C-terminus - - 3.7.1.12 ko:K02189 ko00860,ko01100,map00860,map01100 - R07772 RC01545,RC02097 ko00000,ko00001,ko01000 - - - CbiG_C,CbiG_N,CbiG_mid k59_1228082_2 713586.KB900536_gene390 5.31e-11 62.4 COG3151@1|root,COG3151@2|Bacteria,1NAPI@1224|Proteobacteria,1SEY8@1236|Gammaproteobacteria,1WYT2@135613|Chromatiales 135613|Chromatiales S Protein of unknown function (DUF1249) - - - ko:K09920 - - - - ko00000 - - - DUF1249 k59_99831_1 525897.Dbac_2683 1.36e-29 111.0 COG0071@1|root,COG0071@2|Bacteria,1N7C7@1224|Proteobacteria,42U0T@68525|delta/epsilon subdivisions,2WRBN@28221|Deltaproteobacteria,2MBT4@213115|Desulfovibrionales 28221|Deltaproteobacteria O Belongs to the small heat shock protein (HSP20) family - - - ko:K13993 ko04141,map04141 - - - ko00000,ko00001,ko03110 - - - HSP20 k59_943258_1 702113.PP1Y_AT11664 3.74e-65 204.0 COG0625@1|root,COG0625@2|Bacteria,1RD7K@1224|Proteobacteria,2TVIB@28211|Alphaproteobacteria,2K59I@204457|Sphingomonadales 204457|Sphingomonadales O Glutathione S-transferase, N-terminal domain - - - - - - - - - - - - GST_N_3 k59_943258_2 1192759.AKIB01000026_gene2146 7.24e-35 125.0 COG0625@1|root,COG0625@2|Bacteria,1R6UY@1224|Proteobacteria,2U1WS@28211|Alphaproteobacteria,2K8ZE@204457|Sphingomonadales 204457|Sphingomonadales O Glutathione S-transferase, C-terminal domain - - 2.5.1.18 ko:K00799 ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418 - R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905 RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944 ko00000,ko00001,ko01000,ko02000 1.A.12.2.2,1.A.12.3.2 - - GST_C,GST_N_3 k59_1338348_1 1235800.C819_01613 2.31e-15 84.0 COG0841@1|root,COG0841@2|Bacteria,1TQ03@1239|Firmicutes,2491S@186801|Clostridia,27IJT@186928|unclassified Lachnospiraceae 186801|Clostridia V AcrB/AcrD/AcrF family czcA - - ko:K03296 - - - - ko00000 2.A.6.2 - - ACR_tran k59_1736331_1 1410620.SHLA_91c000050 6.29e-06 53.5 COG3181@1|root,COG3181@2|Bacteria,1MWVK@1224|Proteobacteria,2TXW7@28211|Alphaproteobacteria,4B8R1@82115|Rhizobiaceae 28211|Alphaproteobacteria S Tripartite tricarboxylate transporter family receptor - - - - - - - - - - - - TctC k59_546301_2 396588.Tgr7_3080 5.47e-22 94.4 COG1082@1|root,COG1082@2|Bacteria,1Q3WR@1224|Proteobacteria,1S04R@1236|Gammaproteobacteria 1236|Gammaproteobacteria G Xylose isomerase - - - - - - - - - - - - AP_endonuc_2 k59_1228110_1 396588.Tgr7_2024 3.8e-82 262.0 COG0272@1|root,COG0272@2|Bacteria,1MV3R@1224|Proteobacteria,1RPAV@1236|Gammaproteobacteria,1WX4B@135613|Chromatiales 135613|Chromatiales L DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA ligA - 6.5.1.2 ko:K01972 ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430 - R00382 RC00005 ko00000,ko00001,ko01000,ko03032,ko03400 - - - BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5 k59_943285_1 1168067.JAGP01000001_gene946 5.48e-52 174.0 COG0330@1|root,COG0330@2|Bacteria,1MV7R@1224|Proteobacteria,1RM8Z@1236|Gammaproteobacteria,460B4@72273|Thiotrichales 72273|Thiotrichales O HflC and HflK could regulate a protease hflC - - ko:K04087 - M00742 - - ko00000,ko00002,ko01000 - - - Band_7 k59_327416_1 266265.Bxe_C0346 2.21e-22 95.9 COG3637@1|root,COG3637@2|Bacteria,1N7IC@1224|Proteobacteria,2VVZ0@28216|Betaproteobacteria,1K72N@119060|Burkholderiaceae 28216|Betaproteobacteria M Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety pagL GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005975,GO:0005976,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008653,GO:0009279,GO:0009311,GO:0009987,GO:0016020,GO:0016021,GO:0016787,GO:0016788,GO:0019637,GO:0019867,GO:0030312,GO:0030313,GO:0031224,GO:0031975,GO:0042802,GO:0042803,GO:0043170,GO:0044237,GO:0044238,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044425,GO:0044462,GO:0044464,GO:0046493,GO:0046983,GO:0050528,GO:0052689,GO:0071704,GO:0071944,GO:1901135,GO:1901269,GO:1903509 - ko:K12976 - - - - ko00000,ko01000,ko01005 - - - PagL k59_943287_1 1380347.JNII01000006_gene1628 2.32e-09 64.3 COG2909@1|root,COG2909@2|Bacteria,2GJAR@201174|Actinobacteria 201174|Actinobacteria K transcriptional regulator - - - - - - - - - - - - AAA_16,GerE k59_943301_1 436308.Nmar_1250 2.19e-29 113.0 COG3794@1|root,arCOG02926@2157|Archaea 2157|Archaea C PFAM blue (type 1) copper domain protein - - - - - - - - - - - - Copper-bind,Kazal_1 k59_327433_2 565045.NOR51B_1463 1.83e-59 193.0 COG5345@1|root,COG5345@2|Bacteria,1MWVH@1224|Proteobacteria,1RP5X@1236|Gammaproteobacteria 1236|Gammaproteobacteria S protein conserved in bacteria - - - - - - - - - - - - DUF2333 k59_1338398_1 459349.CLOAM1310 2.19e-43 158.0 COG0044@1|root,COG0044@2|Bacteria,2NNWP@2323|unclassified Bacteria 2|Bacteria F Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily pyrC - 3.5.2.3 ko:K01465 ko00240,ko01100,map00240,map01100 M00051 R01993 RC00632 ko00000,ko00001,ko00002,ko01000 - - - Amidohydro_1 k59_1400972_1 43989.cce_2051 5.03e-16 76.6 COG0480@1|root,COG0480@2|Bacteria,1G2JV@1117|Cyanobacteria,3KHE9@43988|Cyanothece 1117|Cyanobacteria J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome - - - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2 k59_1400972_2 1121124.JNIX01000002_gene80 8.76e-20 90.1 COG2962@1|root,COG2962@2|Bacteria,1MX5G@1224|Proteobacteria,2TV8D@28211|Alphaproteobacteria,2KG4P@204458|Caulobacterales 204458|Caulobacterales S TIGRFAM RarD protein, DMT superfamily transporter - - - ko:K05786 - - - - ko00000,ko02000 2.A.7.7 - - EamA k59_327438_1 1123276.KB893279_gene2171 5.72e-91 282.0 COG0006@1|root,COG0006@2|Bacteria,4NF0F@976|Bacteroidetes,47JWC@768503|Cytophagia 976|Bacteroidetes E Metallopeptidase family M24 - - - - - - - - - - - - Peptidase_M24 k59_1228148_1 283699.D172_3236 4.73e-20 92.8 COG1629@1|root,COG4771@2|Bacteria,1MUWN@1224|Proteobacteria,1RN1E@1236|Gammaproteobacteria,2Q0FU@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria P COG1629 Outer membrane receptor proteins, mostly Fe transport - - - - - - - - - - - - CarbopepD_reg_2,CarboxypepD_reg,Plug,TonB_dep_Rec k59_1571113_1 1229909.NSED_05505 4.88e-155 441.0 COG1405@1|root,arCOG01981@2157|Archaea,41SXZ@651137|Thaumarchaeota 651137|Thaumarchaeota K Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB) - - - ko:K03124 ko03022,ko05169,ko05203,map03022,map05169,map05203 - - - ko00000,ko00001,ko03021 - - - TFIIB,TF_Zn_Ribbon k59_546362_1 404589.Anae109_0939 1.39e-64 222.0 COG1793@1|root,COG3285@1|root,COG1793@2|Bacteria,COG3285@2|Bacteria,1MVWY@1224|Proteobacteria,42U99@68525|delta/epsilon subdivisions,2WQ5W@28221|Deltaproteobacteria,2YWMR@29|Myxococcales 28221|Deltaproteobacteria L ATP dependent DNA ligase domain protein - - 6.5.1.1 ko:K01971 ko03450,map03450 - R00381 RC00005 ko00000,ko00001,ko01000,ko03400 - - - DNA_ligase_A_C,DNA_ligase_A_M,LigD_N k59_1282005_1 1479239.JQMU01000001_gene1588 1.62e-70 229.0 COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2TR2W@28211|Alphaproteobacteria,2K1MV@204457|Sphingomonadales 204457|Sphingomonadales IQ COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II - - - - - - - - - - - - AMP-binding,AMP-binding_C k59_1451940_2 458817.Shal_0991 5.31e-99 294.0 COG1794@1|root,COG1794@2|Bacteria,1MV03@1224|Proteobacteria,1RMHT@1236|Gammaproteobacteria,2Q8K1@267890|Shewanellaceae 1236|Gammaproteobacteria M Asp/Glu/Hydantoin racemase ygeA GO:0000270,GO:0003674,GO:0003824,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016853,GO:0016854,GO:0016855,GO:0030203,GO:0034645,GO:0036361,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0047661,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 5.1.1.13 ko:K01779 ko00250,ko01054,map00250,map01054 - R00491 RC00302 ko00000,ko00001,ko01000 - - - Asp_Glu_race k59_1451940_3 1122137.AQXF01000004_gene1617 3.28e-24 98.2 COG0077@1|root,COG0077@2|Bacteria,1MU60@1224|Proteobacteria,2TSUT@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Prephenate dehydratase pheA - 4.2.1.51 ko:K04518 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00024 R00691,R01373 RC00360 ko00000,ko00001,ko00002,ko01000 - - - PDT k59_99910_1 1346791.M529_08025 8.66e-63 202.0 COG0583@1|root,COG0583@2|Bacteria,1MXRP@1224|Proteobacteria,2TRVK@28211|Alphaproteobacteria,2K2UE@204457|Sphingomonadales 204457|Sphingomonadales K Bacterial regulatory helix-turn-helix protein, lysR family - - - - - - - - - - - - HTH_1,LysR_substrate k59_1282010_1 746697.Aeqsu_2704 2.52e-60 202.0 COG0861@1|root,COG0861@2|Bacteria,4NH7P@976|Bacteroidetes,1HZCI@117743|Flavobacteriia 976|Bacteroidetes P membrane protein TerC alx - - ko:K05794 - - - - ko00000 - - - TerC k59_1282010_2 58344.JOEL01000025_gene664 1.01e-29 117.0 COG4339@1|root,COG4339@2|Bacteria,2GMYQ@201174|Actinobacteria 201174|Actinobacteria L nUDIX hydrolase - - - - - - - - - - - - DUF4031,HD k59_1282010_3 941639.BCO26_2584 3.83e-68 221.0 COG0388@1|root,COG0454@1|root,COG0388@2|Bacteria,COG0456@2|Bacteria,1TQAZ@1239|Firmicutes,4HCQW@91061|Bacilli,1ZB16@1386|Bacillus 91061|Bacilli K Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase yhcX - - - - - - - - - - - Acetyltransf_1,CN_hydrolase k59_1338434_1 1297742.A176_02571 1.83e-51 181.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria 1224|Proteobacteria T Response regulator containing CheY-like receiver AAA-type ATPase and DNA-binding domains actB - - - - - - - - - - - HTH_8,Response_reg,Sigma54_activat k59_773241_1 1458357.BG58_05620 2.72e-135 387.0 COG0623@1|root,COG0623@2|Bacteria,1MV05@1224|Proteobacteria,2VJQ0@28216|Betaproteobacteria,1JZNA@119060|Burkholderiaceae 28216|Betaproteobacteria I Enoyl- acyl-carrier-protein reductase NADH fabI_1 - 1.3.1.10,1.3.1.9 ko:K00208 ko00061,ko00333,ko00780,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01100,map01130,map01212 M00083,M00572 R01404,R04429,R04430,R04724,R04725,R04955,R04956,R04958,R04959,R04961,R04962,R04966,R04967,R04969,R04970,R07765,R10118,R10122,R11671 RC00052,RC00076,RC00120 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 k59_1736403_1 1042377.AFPJ01000052_gene1566 1.1e-80 247.0 COG3220@1|root,COG3220@2|Bacteria,1MURE@1224|Proteobacteria,1RQ9H@1236|Gammaproteobacteria,464IP@72275|Alteromonadaceae 1236|Gammaproteobacteria S protein conserved in bacteria - - - ko:K09930 - - - - ko00000 - - - DUF692 k59_107034_1 1006004.GBAG_2247 1.26e-45 163.0 COG2719@1|root,COG2719@2|Bacteria,1MW6U@1224|Proteobacteria,1RPU2@1236|Gammaproteobacteria 1236|Gammaproteobacteria S SpoVR family ycgB GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0033554,GO:0050896,GO:0051716 - ko:K06415 - - - - ko00000 - - - SpoVR k59_668597_1 1163407.UU7_07328 0.000351 49.3 COG1629@1|root,COG1629@2|Bacteria,COG4771@2|Bacteria,1MU9K@1224|Proteobacteria,1RMTG@1236|Gammaproteobacteria,1X4KS@135614|Xanthomonadales 135614|Xanthomonadales P TonB dependent receptor - - - - - - - - - - - - Plug,STN,TonB_dep_Rec k59_50964_2 314230.DSM3645_10732 1.5e-45 165.0 COG0370@1|root,COG0370@2|Bacteria,2IYCI@203682|Planctomycetes 203682|Planctomycetes P transporter of a GTP-driven Fe(2 ) uptake system feoB - - ko:K04759 - - - - ko00000,ko02000 9.A.8.1 - - FeoB_C,FeoB_N,Gate k59_1578192_1 616991.JPOO01000003_gene721 1.7e-20 89.7 COG1960@1|root,COG1960@2|Bacteria,4NG2G@976|Bacteroidetes,1HXCS@117743|Flavobacteriia,23GPU@178469|Arenibacter 976|Bacteroidetes I Acyl-CoA dehydrogenase, C-terminal domain fadE - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_1578192_2 886377.Murru_0101 1.87e-52 175.0 COG0183@1|root,COG0183@2|Bacteria,4NE3Q@976|Bacteroidetes,1HWRC@117743|Flavobacteriia 976|Bacteroidetes I Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation fadA - 2.3.1.16 ko:K00632 ko00071,ko00280,ko00281,ko00362,ko00592,ko00642,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00362,map00592,map00642,map01100,map01110,map01120,map01130,map01212 M00087,M00113 R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095 RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955 ko00000,ko00001,ko00002,ko01000 - - - Thiolase_C,Thiolase_N k59_616424_1 1415780.JPOG01000001_gene3203 1.32e-81 252.0 COG0463@1|root,COG0463@2|Bacteria,1MX1N@1224|Proteobacteria,1S06M@1236|Gammaproteobacteria,1X9P3@135614|Xanthomonadales 135614|Xanthomonadales M Glycosyl transferase, family 2 - - - - - - - - - - - - - k59_616424_2 1353528.DT23_05710 5.86e-06 53.1 COG1943@1|root,COG1943@2|Bacteria,1P8IT@1224|Proteobacteria,2TRKV@28211|Alphaproteobacteria,2XMHB@285107|Thioclava 28211|Alphaproteobacteria L Sulfotransferase family - - - - - - - - - - - - Sulfotransfer_2 k59_1289524_1 1122137.AQXF01000006_gene750 3.85e-63 205.0 COG0174@1|root,COG0174@2|Bacteria,1MU6V@1224|Proteobacteria,2TRCP@28211|Alphaproteobacteria 28211|Alphaproteobacteria E glutamine synthetase glnA1 - 6.3.1.2 ko:K01915 ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 - R00253 RC00010,RC02798 ko00000,ko00001,ko01000,ko04147 - - - Gln-synt_C k59_1289524_2 1122137.AQXF01000006_gene749 2.26e-75 232.0 COG2071@1|root,COG2071@2|Bacteria,1MV8E@1224|Proteobacteria,2TSU3@28211|Alphaproteobacteria 28211|Alphaproteobacteria S -glutamine - - - ko:K07010 - - - - ko00000,ko01002 - - - Peptidase_C26 k59_553319_1 1122137.AQXF01000001_gene3181 1.16e-14 69.3 2DDTV@1|root,2ZJ8Z@2|Bacteria,1P7ZX@1224|Proteobacteria,2UYEP@28211|Alphaproteobacteria 28211|Alphaproteobacteria S PilZ domain - - - - - - - - - - - - PilZ k59_553319_2 1122137.AQXF01000001_gene3182 1.21e-97 298.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2TQPG@28211|Alphaproteobacteria 28211|Alphaproteobacteria T COG2204 Response regulator containing CheY-like receiver AAA-type ATPase and DNA-binding domains luxO - - ko:K10912 ko02020,ko02024,ko05111,map02020,map02024,map05111 M00513 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_1743226_1 247633.GP2143_13771 1.33e-68 219.0 COG1253@1|root,COG1253@2|Bacteria,1MWT3@1224|Proteobacteria,1RQBC@1236|Gammaproteobacteria,1J8SC@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Domain of unknown function DUF21 - - - - - - - - - - - - CBS,DUF21 k59_1408361_1 715451.ambt_20880 1.33e-53 183.0 COG1752@1|root,COG1752@2|Bacteria,1NT1Q@1224|Proteobacteria,1RP9M@1236|Gammaproteobacteria,46B1V@72275|Alteromonadaceae 1236|Gammaproteobacteria S Patatin-like phospholipase - - - - - - - - - - - - Patatin k59_1289527_2 1096769.Pelub83DRAFT_0415 4.67e-22 87.0 2FDFA@1|root,345GY@2|Bacteria,1P1RR@1224|Proteobacteria 1224|Proteobacteria - - - - - - - - - - - - - - - k59_1520611_1 158500.BV97_04861 1.1e-103 306.0 COG0745@1|root,COG0745@2|Bacteria,1MY3D@1224|Proteobacteria,2TTKG@28211|Alphaproteobacteria,2K21J@204457|Sphingomonadales 204457|Sphingomonadales K Transcriptional regulator - - - - - - - - - - - - Response_reg,Trans_reg_C k59_1520614_1 1046724.KB889908_gene961 2.77e-51 180.0 COG0768@1|root,COG0768@2|Bacteria,1MV8C@1224|Proteobacteria,1RN9H@1236|Gammaproteobacteria,464KX@72275|Alteromonadaceae 1236|Gammaproteobacteria M Catalyzes cross-linking of the peptidoglycan cell wall mrdA GO:0000270,GO:0003674,GO:0003824,GO:0004180,GO:0004185,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006022,GO:0006023,GO:0006024,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0008238,GO:0008360,GO:0008658,GO:0009002,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016021,GO:0016043,GO:0016787,GO:0017171,GO:0019538,GO:0022603,GO:0022604,GO:0030203,GO:0031224,GO:0031226,GO:0031406,GO:0033218,GO:0033293,GO:0034645,GO:0036094,GO:0042221,GO:0042493,GO:0042546,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044425,GO:0044459,GO:0044464,GO:0045229,GO:0046677,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051128,GO:0065007,GO:0065008,GO:0070008,GO:0070011,GO:0070589,GO:0071554,GO:0071555,GO:0071704,GO:0071840,GO:0071944,GO:0071972,GO:0097159,GO:0140096,GO:1901135,GO:1901137,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901681 3.4.16.4 ko:K05515 ko00550,ko01501,map00550,map01501 - - - ko00000,ko00001,ko01000,ko01011 - - iEcE24377_1341.EcE24377A_0661,iPC815.YPO2604 PBP_dimer,Transpeptidase k59_1289535_1 159087.Daro_2988 5.66e-109 326.0 COG0820@1|root,COG0820@2|Bacteria,1MUYK@1224|Proteobacteria,2VIBN@28216|Betaproteobacteria,2KVXU@206389|Rhodocyclales 206389|Rhodocyclales J Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs rlmN - 2.1.1.192 ko:K06941 - - - - ko00000,ko01000,ko03009 - - - Radical_SAM k59_1290668_2 1122137.AQXF01000001_gene2909 2.78e-11 59.7 COG0718@1|root,COG0718@2|Bacteria,1RGZD@1224|Proteobacteria,2UBQB@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection ybaB - - ko:K09747 - - - - ko00000 - - - YbaB_DNA_bd k59_951586_1 1125973.JNLC01000012_gene950 7.09e-174 501.0 COG1797@1|root,COG1797@2|Bacteria,1MV7Z@1224|Proteobacteria,2TR0W@28211|Alphaproteobacteria,3JTID@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria H Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L-glutamine or ammonia as the nitrogen source cobB - 6.3.5.11,6.3.5.9 ko:K02224 ko00860,ko01100,ko01120,map00860,map01100,map01120 - R05224,R05815 RC00010,RC01301 ko00000,ko00001,ko01000 - - - AAA_26,CbiA,GATase_3 k59_1687325_1 292564.Cyagr_2675 2.48e-264 746.0 COG3119@1|root,COG3119@2|Bacteria,1G22U@1117|Cyanobacteria,22RRC@167375|Cyanobium 1117|Cyanobacteria P Sulfatase - - 3.1.6.1 ko:K01130 ko00140,ko00600,map00140,map00600 - R03980,R04856 RC00128,RC00231 ko00000,ko00001,ko01000 - - - Sulfatase k59_730818_1 1122599.AUGR01000024_gene1368 6.56e-39 145.0 COG0728@1|root,COG0728@2|Bacteria,1MUH0@1224|Proteobacteria,1RMXX@1236|Gammaproteobacteria,1XH8T@135619|Oceanospirillales 135619|Oceanospirillales S Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane murJ - - ko:K03980 - - - - ko00000,ko01011,ko02000 2.A.66.4 - - MVIN k59_951590_1 931626.Awo_c12700 2.97e-11 65.5 COG1696@1|root,COG1696@2|Bacteria,1TP52@1239|Firmicutes,248V4@186801|Clostridia,25V5N@186806|Eubacteriaceae 186801|Clostridia M membrane protein involved in D-alanine export algI - - ko:K19294 - - - - ko00000 - - - MBOAT k59_951590_2 398525.KB900701_gene7523 2.56e-16 78.6 COG0451@1|root,COG0451@2|Bacteria,1PB4Y@1224|Proteobacteria,2TTV7@28211|Alphaproteobacteria,3JWIV@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria M 3-beta hydroxysteroid dehydrogenase/isomerase family - - 5.1.3.2 ko:K01784 ko00052,ko00520,ko01100,map00052,map00520,map01100 M00361,M00362,M00632 R00291,R02984 RC00289 ko00000,ko00001,ko00002,ko01000 - - - Epimerase k59_730826_1 1157637.KB892154_gene7272 8.91e-26 110.0 COG0577@1|root,COG0577@2|Bacteria,2H997@201174|Actinobacteria 201174|Actinobacteria V ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component - - - - - - - - - - - - FtsX k59_669712_1 1335757.SPICUR_08290 1.97e-54 180.0 COG0050@1|root,COG0050@2|Bacteria,1MVC0@1224|Proteobacteria,1RMYX@1236|Gammaproteobacteria,1WWIK@135613|Chromatiales 135613|Chromatiales J This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis tuf - - ko:K02358 - - - - ko00000,ko03012,ko03029,ko04147 - - - GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3 k59_498730_2 228410.NE1250 1.14e-08 62.8 COG0643@1|root,COG2198@1|root,COG0643@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,2VJSZ@28216|Betaproteobacteria,372P0@32003|Nitrosomonadales 28216|Betaproteobacteria T Response regulator receiver pilL - 2.7.13.3 ko:K02487,ko:K03407,ko:K06596 ko02020,ko02025,ko02030,map02020,map02025,map02030 M00506,M00507 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 - - - CheW,H-kinase_dim,HATPase_c,Hpt,Response_reg k59_1460333_1 234267.Acid_0127 4.03e-18 84.3 COG1102@1|root,COG1102@2|Bacteria 2|Bacteria F Psort location Cytoplasmic, score - - 2.4.2.8 ko:K00760 ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 - R00190,R01132,R01229,R02142,R08237,R08238,R08245 RC00063,RC00122 ko00000,ko00001,ko01000 - - - Cytidylate_kin2,GAF_2,Pribosyltran k59_1460333_2 1121945.ATXS01000001_gene2179 2.76e-16 77.8 COG0404@1|root,arCOG00756@2157|Archaea,2XU1F@28890|Euryarchaeota,23SQA@183963|Halobacteria 183963|Halobacteria E The glycine cleavage system catalyzes the degradation of glycine gcvT - 2.1.2.10 ko:K00605 ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200 M00532 R01221,R02300,R04125 RC00022,RC00069,RC00183,RC02834 ko00000,ko00001,ko00002,ko01000 - - - GCV_T,GCV_T_C k59_162614_1 1397528.Q671_14925 6.87e-32 128.0 COG2199@1|root,COG3706@2|Bacteria,1NECV@1224|Proteobacteria,1S1ZR@1236|Gammaproteobacteria,1XHXG@135619|Oceanospirillales 135619|Oceanospirillales T Diguanylate cyclase - - - - - - - - - - - - GGDEF,PAS k59_1007182_1 1122194.AUHU01000003_gene1924 1.22e-57 187.0 COG0109@1|root,COG0109@2|Bacteria,1MW3S@1224|Proteobacteria,1RNHC@1236|Gammaproteobacteria,465UQ@72275|Alteromonadaceae 1236|Gammaproteobacteria O Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group cyoE GO:0003674,GO:0003824,GO:0004311,GO:0004659,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0015980,GO:0016020,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044464,GO:0045333,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.141 ko:K02257 ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714 M00154 R07411 RC01786 ko00000,ko00001,ko00002,ko01000,ko01006,ko03029 - - iJN746.PP_0110 UbiA k59_1007182_2 106370.Francci3_0915 3.34e-13 72.0 COG1999@1|root,COG1999@2|Bacteria,2GKF0@201174|Actinobacteria,4EVKF@85013|Frankiales 201174|Actinobacteria S SCO1 SenC - - - ko:K07152 - - - - ko00000,ko03029 - - - SCO1-SenC k59_1180198_1 95619.PM1_0221305 4.13e-41 144.0 COG1024@1|root,COG1024@2|Bacteria,1RAAV@1224|Proteobacteria,1RRTJ@1236|Gammaproteobacteria 1236|Gammaproteobacteria I Enoyl-CoA hydratase - - 4.2.1.17 ko:K01692 ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212 M00032,M00087 R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093 RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 - - - ECH_1 k59_951611_1 1122603.ATVI01000009_gene2516 2.51e-31 122.0 COG3031@1|root,COG3031@2|Bacteria,1RD3I@1224|Proteobacteria,1RQKA@1236|Gammaproteobacteria,1X6CK@135614|Xanthomonadales 135614|Xanthomonadales U Type II secretion system protein C - - - - - - - - - - - - PDZ_2,T2SSC k59_1687355_1 1122137.AQXF01000001_gene2937 5.28e-129 374.0 COG0730@1|root,COG0730@2|Bacteria,1MWX2@1224|Proteobacteria,2TRIC@28211|Alphaproteobacteria 28211|Alphaproteobacteria S membrane transporter protein MA20_19835 - - ko:K07090 - - - - ko00000 - - - TauE k59_617616_2 221288.JH992901_gene1727 3.34e-79 246.0 COG1215@1|root,COG1215@2|Bacteria,1GHF8@1117|Cyanobacteria 1117|Cyanobacteria M Glycosyltransferase like family 2 - - - - - - - - - - - - Glycos_transf_2 k59_277834_1 220664.PFL_1871 3.39e-07 50.1 COG0684@1|root,COG0684@2|Bacteria,1RH18@1224|Proteobacteria,1RS9U@1236|Gammaproteobacteria,1YM1N@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria H Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions rraA - - ko:K02553 - - - - ko00000,ko03019 - - - RraA-like k59_277834_2 1411685.U062_00371 4.48e-41 151.0 COG1960@1|root,COG1960@2|Bacteria,1MU20@1224|Proteobacteria,1RNV1@1236|Gammaproteobacteria,1J4EB@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria I COG1960 Acyl-CoA dehydrogenases - - - ko:K20035 ko00920,map00920 - R11130 RC03363 ko00000,ko00001,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_C,Acyl-CoA_dh_M,Acyl-CoA_dh_N,AcylCoA_DH_N k59_669725_1 936053.I1CKD9 3.15e-50 180.0 COG0265@1|root,KOG1421@2759|Eukaryota,39J7H@33154|Opisthokonta,3P060@4751|Fungi,1GSR9@112252|Fungi incertae sedis 4751|Fungi O Trypsin-like peptidase domain - - - - - - - - - - - - PDZ_1,Trypsin_2 k59_840606_1 436308.Nmar_0649 4.75e-174 491.0 COG1260@1|root,arCOG04213@2157|Archaea,41SEZ@651137|Thaumarchaeota 651137|Thaumarchaeota I Myo-inositol-1-phosphate synthase - - 5.5.1.4 ko:K01858 ko00521,ko00562,ko01100,ko01130,map00521,map00562,map01100,map01130 - R07324 RC01804 ko00000,ko00001,ko01000 - - - Inos-1-P_synth k59_162623_1 1304878.AUGD01000033_gene3242 8.26e-58 187.0 COG2030@1|root,COG2030@2|Bacteria,1RFHT@1224|Proteobacteria,2UKBG@28211|Alphaproteobacteria,3K446@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria I PFAM MaoC domain protein dehydratase - - - - - - - - - - - - MaoC_dehydratas k59_951622_2 269799.Gmet_2228 7.23e-19 84.7 COG0824@1|root,COG0824@2|Bacteria,1RF7Q@1224|Proteobacteria,42W9H@68525|delta/epsilon subdivisions,2WS5R@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Thioesterase-like superfamily - - - ko:K07107 - - - - ko00000,ko01000 - - - 4HBT_2 k59_498742_1 887898.HMPREF0551_1153 2.69e-06 53.9 28IWK@1|root,2Z8UV@2|Bacteria,1P9EC@1224|Proteobacteria,2VJZY@28216|Betaproteobacteria,1KGQC@119060|Burkholderiaceae 28216|Betaproteobacteria S General Secretory Pathway gspN - - ko:K02463 ko05111,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - T2SSN k59_1290731_2 1194972.MVAC_16776 1.14e-30 112.0 2EUA2@1|root,32E0M@2|Bacteria,2HBJI@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - - k59_1290736_1 391603.FBALC1_07533 7.36e-57 188.0 COG4948@1|root,COG4948@2|Bacteria,4NEBX@976|Bacteroidetes,1HY3V@117743|Flavobacteriia 976|Bacteroidetes M mandelate racemase menC - - - - - - - - - - - MR_MLE_C k59_1632105_1 67267.JNXT01000003_gene3817 5.05e-07 58.9 COG3321@1|root,COG3321@2|Bacteria,2H477@201174|Actinobacteria 201174|Actinobacteria Q polyketide synthase - - - - - - - - - - - - Acyl_transf_1,Docking,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,PS-DH,ketoacyl-synt k59_1290738_1 172088.AUGA01000047_gene1376 4.77e-17 77.0 2A9UQ@1|root,30Z2J@2|Bacteria,1RJX4@1224|Proteobacteria,2U9WA@28211|Alphaproteobacteria,3K00C@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_1744340_1 498211.CJA_2923 1.85e-112 333.0 COG0206@1|root,COG0206@2|Bacteria,1MV2X@1224|Proteobacteria,1RPZS@1236|Gammaproteobacteria,1FGY5@10|Cellvibrio 1236|Gammaproteobacteria D Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity ftsZ GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005515,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0022607,GO:0032153,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034622,GO:0035639,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043933,GO:0044085,GO:0044424,GO:0044464,GO:0051258,GO:0051301,GO:0065003,GO:0071840,GO:0097159,GO:0097367,GO:1901265,GO:1901363 - ko:K03531 ko04112,map04112 - - - ko00000,ko00001,ko02048,ko03036,ko04812 - - - FtsZ_C,Tubulin k59_900799_1 745310.G432_00475 9.57e-78 255.0 COG4773@1|root,COG4773@2|Bacteria,1QTXJ@1224|Proteobacteria,2TZ62@28211|Alphaproteobacteria,2K0KJ@204457|Sphingomonadales 204457|Sphingomonadales P TonB dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_108195_1 1123325.JHUV01000015_gene230 3.74e-66 214.0 COG0304@1|root,COG0304@2|Bacteria,2G3SR@200783|Aquificae 200783|Aquificae I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP fabF - 2.3.1.179 ko:K09458 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119 RC00039,RC02728,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Ketoacyl-synt_C,ketoacyl-synt k59_1235972_1 330214.NIDE0231 8.71e-58 184.0 COG1143@1|root,COG1143@2|Bacteria,3J0N0@40117|Nitrospirae 40117|Nitrospirae C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient - - 1.6.5.3 ko:K00338 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Fer4 k59_1235972_2 330214.NIDE0230 1.39e-26 101.0 COG0839@1|root,COG0839@2|Bacteria 2|Bacteria C Belongs to the complex I subunit 6 family nuoJ - 1.6.5.3 ko:K00339 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q3 k59_1521752_1 2340.JV46_07290 5.9e-19 79.3 COG0255@1|root,COG0255@2|Bacteria,1N6PR@1224|Proteobacteria,1SCBN@1236|Gammaproteobacteria,1J6WB@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Belongs to the universal ribosomal protein uL29 family rpmC GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02904 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L29 k59_1521752_2 1121015.N789_06260 9e-47 152.0 COG0197@1|root,COG0197@2|Bacteria,1RA0Z@1224|Proteobacteria,1S201@1236|Gammaproteobacteria,1X6EI@135614|Xanthomonadales 135614|Xanthomonadales J Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs rplP GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0097159,GO:1901363,GO:1990904 - ko:K02878 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L16 k59_781073_1 1415778.JQMM01000001_gene422 2.82e-44 147.0 COG1981@1|root,COG1981@2|Bacteria,1RHGS@1224|Proteobacteria,1S5XY@1236|Gammaproteobacteria,1J6C5@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Uncharacterised protein family (UPF0093) - - - ko:K08973 - - - - ko00000 - - - UPF0093 k59_781073_2 1125973.JNLC01000011_gene344 1.85e-15 75.1 COG1073@1|root,COG1073@2|Bacteria,1MX88@1224|Proteobacteria,2TSRE@28211|Alphaproteobacteria,3JSR8@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S Serine aminopeptidase, S33 MA20_24420 - - ko:K06889 - - - - ko00000 - - - Abhydrolase_6,Hydrolase_4 k59_1744365_1 396595.TK90_2170 0.000394 40.4 COG0051@1|root,COG0051@2|Bacteria,1RGWF@1224|Proteobacteria,1S3QX@1236|Gammaproteobacteria,1WYRW@135613|Chromatiales 135613|Chromatiales J Involved in the binding of tRNA to the ribosomes rpsJ - - ko:K02946 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S10 k59_1235994_1 491952.Mar181_0079 4.19e-33 132.0 COG4247@1|root,COG4247@2|Bacteria,1MVTA@1224|Proteobacteria,1RQXH@1236|Gammaproteobacteria,1XHZ2@135619|Oceanospirillales 135619|Oceanospirillales I Phytase - - 3.1.3.8 ko:K01083 ko00562,map00562 - R03371 RC00078 ko00000,ko00001,ko01000 - - - Phytase k59_1346906_1 1397527.Q670_03070 3.43e-11 66.2 COG0581@1|root,COG0581@2|Bacteria,1MUWB@1224|Proteobacteria,1RPV9@1236|Gammaproteobacteria,1XJ28@135619|Oceanospirillales 135619|Oceanospirillales P Phosphate transport system permease pstA - - ko:K02038 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko02000 3.A.1.7 - - BPD_transp_1,DUF3333 k59_1235999_1 1380600.AUYN01000007_gene3053 8.39e-64 203.0 COG3087@1|root,COG3087@2|Bacteria,4NF9U@976|Bacteroidetes,1HYQM@117743|Flavobacteriia 976|Bacteroidetes D sporulation - - - - - - - - - - - - SPOR k59_277884_1 1297742.A176_00361 1.21e-29 117.0 2DR4U@1|root,33A62@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - CreD k59_277899_1 1122137.AQXF01000005_gene1121 1.11e-178 509.0 COG1003@1|root,COG1003@2|Bacteria,1MUDP@1224|Proteobacteria,2TSFF@28211|Alphaproteobacteria 28211|Alphaproteobacteria E The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor gcvP - 1.4.4.2 ko:K00281,ko:K00283 ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200 M00532 R01221,R03425 RC00022,RC00929,RC02834,RC02880 ko00000,ko00001,ko00002,ko01000 - - - Aminotran_5,GDC-P k59_277899_2 1122137.AQXF01000005_gene1122 5.92e-07 50.4 COG0403@1|root,COG0403@2|Bacteria,1MVC1@1224|Proteobacteria,2TR6C@28211|Alphaproteobacteria 28211|Alphaproteobacteria E The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor gcvPA - 1.4.4.2 ko:K00282 ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200 - R01221,R03425 RC00022,RC00929,RC02834,RC02880 ko00000,ko00001,ko01000 - - - GDC-P k59_900842_1 751994.AGIG01000028_gene1658 6.8e-52 183.0 COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,1RNJI@1236|Gammaproteobacteria,1J4ZV@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L it can initiate unwinding at a nick in the DNA. It binds to the single-stranded DNA and acts in a progressive fashion along the DNA in the 3' to 5' direction rep GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006268,GO:0006725,GO:0006807,GO:0006996,GO:0007049,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009628,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022402,GO:0032392,GO:0032508,GO:0034641,GO:0034645,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044786,GO:0044787,GO:0046483,GO:0050896,GO:0051276,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360,GO:1901576 3.6.4.12 ko:K03656,ko:K03657 ko03420,ko03430,map03420,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - UvrD-helicase,UvrD_C k59_498794_1 1385517.N800_10640 2.69e-08 61.6 COG0457@1|root,COG3710@1|root,COG5616@1|root,COG0457@2|Bacteria,COG3710@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,1S5TW@1236|Gammaproteobacteria,1X5PU@135614|Xanthomonadales 135614|Xanthomonadales K Transcriptional regulatory protein, C terminal - - - - - - - - - - - - TPR_16,TPR_2,TPR_8,Trans_reg_C k59_392661_1 478801.Ksed_16310 3.39e-05 47.0 COG0404@1|root,COG0404@2|Bacteria,2GJ47@201174|Actinobacteria,1ZVG2@145357|Dermacoccaceae 201174|Actinobacteria E The glycine cleavage system catalyzes the degradation of glycine gcvT GO:0005575,GO:0005618,GO:0005623,GO:0008150,GO:0030312,GO:0040007,GO:0044464,GO:0071944 2.1.2.10 ko:K00605 ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200 M00532 R01221,R02300,R04125 RC00022,RC00069,RC00183,RC02834 ko00000,ko00001,ko00002,ko01000 - - - GCV_T,GCV_T_C k59_392661_3 1440774.Y900_002460 8.19e-11 61.6 COG1940@1|root,COG1940@2|Bacteria,2GJA0@201174|Actinobacteria,233KN@1762|Mycobacteriaceae 201174|Actinobacteria G catalyzes the phosphorylation of glucose using polyphosphate or ATP as the phosphoryl donor ppgK GO:0003674,GO:0003824,GO:0004340,GO:0004396,GO:0005975,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019200,GO:0019637,GO:0040007,GO:0044237,GO:0044238,GO:0044262,GO:0046835,GO:0047330,GO:0051156,GO:0071704,GO:1901135 2.7.1.2,2.7.1.63 ko:K00845,ko:K00886 ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200 M00001,M00549 R00299,R01600,R01786,R02187,R02189 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - ROK k59_171907_4 1131266.ARWQ01000035_gene713 5e-20 82.8 arCOG08688@1|root,arCOG08688@2157|Archaea,41T55@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1358175_2 314287.GB2207_06248 2.49e-51 164.0 COG0100@1|root,COG0100@2|Bacteria,1RD0A@1224|Proteobacteria,1S3Q2@1236|Gammaproteobacteria,1J5YN@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome rpsK GO:0000028,GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0016070,GO:0016072,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034622,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0048027,GO:0065003,GO:0070181,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02948 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S11 k59_171909_1 1328313.DS2_07633 1.03e-71 225.0 COG1349@1|root,COG1349@2|Bacteria,1QM4U@1224|Proteobacteria,1RNN2@1236|Gammaproteobacteria,465D2@72275|Alteromonadaceae 1236|Gammaproteobacteria K DeoR C terminal sensor domain ulaR GO:0003674,GO:0005488,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0019842,GO:0030246,GO:0031406,GO:0031418,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0048029,GO:0048037,GO:0050662,GO:0071704,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576 - ko:K03477 - - - - ko00000,ko03000 - - - DeoRC,HTH_DeoR k59_171909_2 342113.DM82_4330 8.74e-19 89.0 COG1556@1|root,COG1556@2|Bacteria,1R4TE@1224|Proteobacteria,2VJCF@28216|Betaproteobacteria,1K1I9@119060|Burkholderiaceae 28216|Betaproteobacteria S LUD domain - - - ko:K00782 - - - - ko00000 - - - LUD_dom k59_2149_2 69395.JQLZ01000002_gene1357 7.85e-44 158.0 COG4993@1|root,COG4993@2|Bacteria,1MUQX@1224|Proteobacteria,2TS2Q@28211|Alphaproteobacteria,2KHSR@204458|Caulobacterales 204458|Caulobacterales C PQQ enzyme repeat - - - - - - - - - - - - Cytochrome_CBB3,PQQ,PQQ_2 k59_341397_1 269799.Gmet_2013 1.52e-16 86.7 COG0726@1|root,COG0726@2|Bacteria,1MVKH@1224|Proteobacteria,42VRI@68525|delta/epsilon subdivisions,2WRUV@28221|Deltaproteobacteria,43VFC@69541|Desulfuromonadales 28221|Deltaproteobacteria G Polysaccharide deacetylase - - - - - - - - - - - - Polysacc_deac_1 k59_905922_1 199310.c0371 2.39e-112 345.0 COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,1RPM5@1236|Gammaproteobacteria,3XNAM@561|Escherichia 1236|Gammaproteobacteria I Catalyzes the dehydrogenation of acyl-coenzymes A (acyl- CoAs) to 2-enoyl-CoAs, the first step of the beta-oxidation cycle of fatty acid degradation. Is required for fadE GO:0003674,GO:0003824,GO:0003995,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009987,GO:0016020,GO:0016042,GO:0016054,GO:0016491,GO:0016627,GO:0019395,GO:0019752,GO:0030258,GO:0032787,GO:0033539,GO:0034440,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044464,GO:0046395,GO:0055114,GO:0071704,GO:0071944,GO:0072329,GO:1901575 - ko:K06445 ko00071,ko01100,ko01212,map00071,map01100,map01212 M00087 R01175,R01279,R03777,R03857,R03990,R04751,R04754 RC00052,RC00076 ko00000,ko00001,ko00002,ko01000 - - iSbBS512_1146.SbBS512_E0217 Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N,DUF1974 k59_1583955_1 991905.SL003B_3709 4.25e-20 98.6 COG0840@1|root,COG2972@1|root,COG0840@2|Bacteria,COG2972@2|Bacteria,1MU9B@1224|Proteobacteria,2TQR7@28211|Alphaproteobacteria 28211|Alphaproteobacteria T methyl-accepting chemotaxis protein - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - HAMP,MCPsignal k59_736892_1 123899.JPQP01000023_gene3098 2.11e-53 191.0 COG1368@1|root,COG1368@2|Bacteria,1MVCM@1224|Proteobacteria,2VMSK@28216|Betaproteobacteria 28216|Betaproteobacteria M sulfatase ltaS2 - - - - - - - - - - - Sulfatase k59_454122_1 880073.Calab_3315 2.26e-87 279.0 COG2217@1|root,COG2217@2|Bacteria,2NNY4@2323|unclassified Bacteria 2|Bacteria P ATPase, P-type (transporting), HAD superfamily, subfamily IC copB - 3.6.3.4 ko:K01533 - - R00086 RC00002 ko00000,ko01000 3.A.3.5 - - E1-E2_ATPase,Hydrolase k59_1697016_1 77586.LPERR10G03390.1 2.13e-10 65.9 KOG4658@1|root,KOG4658@2759|Eukaryota,383P6@33090|Viridiplantae,3GWW3@35493|Streptophyta,3KVX7@4447|Liliopsida,3ID78@38820|Poales 35493|Streptophyta T NB-ARC domain - - - - - - - - - - - - Jacalin,NB-ARC k59_962604_1 1178825.ALIH01000007_gene1716 1.94e-69 220.0 COG0436@1|root,COG0436@2|Bacteria,4NF2E@976|Bacteroidetes,1HXQX@117743|Flavobacteriia 976|Bacteroidetes E Aminotransferase dapL - 2.6.1.83 ko:K10206,ko:K14261 ko00300,ko01100,ko01110,ko01130,ko01230,map00300,map01100,map01110,map01130,map01230 M00527 R07613 RC00006,RC01847 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_1_2 k59_962604_2 1380600.AUYN01000009_gene1230 8.1e-21 89.7 COG0287@1|root,COG0287@2|Bacteria,4NEKF@976|Bacteroidetes,1HWRY@117743|Flavobacteriia 976|Bacteroidetes E prephenate dehydrogenase tyrA - 1.3.1.12 ko:K04517 ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230 M00025 R01728 RC00125 ko00000,ko00001,ko00002,ko01000 - - - PDH k59_454135_1 1120963.KB894499_gene558 9.43e-34 118.0 COG0236@1|root,COG0236@2|Bacteria,1MZ4P@1224|Proteobacteria,1S8X4@1236|Gammaproteobacteria,2Q2ZC@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria IQ Carrier of the growing fatty acid chain in fatty acid biosynthesis acpP GO:0000035,GO:0000036,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008289,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016053,GO:0019637,GO:0019752,GO:0019842,GO:0031177,GO:0032787,GO:0033218,GO:0036094,GO:0042221,GO:0042493,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0044620,GO:0046394,GO:0046467,GO:0046493,GO:0048037,GO:0050896,GO:0051192,GO:0071704,GO:0072330,GO:0072341,GO:0090407,GO:0140104,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 - ko:K02078 - - - - ko00000,ko00001 - - - PP-binding k59_1188630_1 1122225.AULQ01000001_gene1931 9.75e-113 332.0 COG1454@1|root,COG1454@2|Bacteria,4PKHV@976|Bacteroidetes,1IMM0@117743|Flavobacteriia 976|Bacteroidetes C Alcohol dehydrogenase class IV - - 1.1.3.48 ko:K19714 - - R11394 RC03427 ko00000,ko01000,ko01005 - - - Fe-ADH k59_1583989_1 84588.SYNW0424 1.2e-36 140.0 COG0119@1|root,COG0119@2|Bacteria,1G4MW@1117|Cyanobacteria,1H2E6@1129|Synechococcus 1117|Cyanobacteria E HMGL-like - - 4.1.3.39 ko:K01666 ko00360,ko00362,ko00621,ko00622,ko01100,ko01120,ko01220,map00360,map00362,map00621,map00622,map01100,map01120,map01220 M00545,M00569 R00750 RC00307,RC00371 br01602,ko00000,ko00001,ko00002,ko01000 - - - HMGL-like k59_1583989_2 714943.Mucpa_4361 8.3e-31 116.0 COG1212@1|root,COG1212@2|Bacteria,4NKB4@976|Bacteroidetes,1IX7F@117747|Sphingobacteriia 976|Bacteroidetes H COG1212 CMP-2-keto-3-deoxyoctulosonic acid synthetase - - 2.7.7.38 ko:K00979 ko00540,ko01100,map00540,map01100 M00063 R03351,R11396 RC00152,RC00910 ko00000,ko00001,ko00002,ko01000,ko01005 - - - CTP_transf_3 k59_1527611_1 977880.RALTA_B1346 4.22e-09 61.2 COG0491@1|root,COG0491@2|Bacteria,1MX4H@1224|Proteobacteria,2VI82@28216|Betaproteobacteria,1K352@119060|Burkholderiaceae 28216|Betaproteobacteria S PFAM beta-lactamase domain protein - - - - - - - - - - - - Lactamase_B k59_567449_1 1229909.NSED_07175 6.38e-49 166.0 COG0119@1|root,arCOG02092@2157|Archaea,41S7Y@651137|Thaumarchaeota 651137|Thaumarchaeota E HMGL-like - - 2.3.3.13 ko:K01649 ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230 M00432 R01213 RC00004,RC00470,RC02754 br01601,ko00000,ko00001,ko00002,ko01000 - - - HMGL-like k59_567449_2 436308.Nmar_1294 4.41e-34 116.0 arCOG01588@1|root,arCOG01588@2157|Archaea,41STK@651137|Thaumarchaeota 651137|Thaumarchaeota E lysine biosynthesis protein LysW - - - ko:K05826 - M00031,M00763 - - ko00000,ko00001,ko00002 - - - - k59_284936_2 1229909.NSED_02275 1.64e-84 252.0 COG1439@1|root,arCOG00721@2157|Archaea,41SPQ@651137|Thaumarchaeota 651137|Thaumarchaeota V PIN domain of ribonuclease - - - ko:K07060 - - - - ko00000,ko01000,ko02048 - - - PIN_6 k59_171928_1 983920.Y88_3715 2.52e-16 75.9 COG0152@1|root,COG0152@2|Bacteria,1MUR9@1224|Proteobacteria,2TR8D@28211|Alphaproteobacteria,2K0D0@204457|Sphingomonadales 204457|Sphingomonadales F Belongs to the SAICAR synthetase family purC - 6.3.2.6 ko:K01923 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04591 RC00064,RC00162 ko00000,ko00001,ko00002,ko01000 - - - SAICAR_synt k59_171928_2 1122137.AQXF01000002_gene535 1.69e-50 162.0 COG5467@1|root,COG5467@2|Bacteria,1MZRN@1224|Proteobacteria,2UC1G@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Domain of unknown function (DUF1476) MA20_09035 - - - - - - - - - - - DUF1476 k59_228171_2 1463858.JOHR01000001_gene6699 1.25e-16 82.8 COG1804@1|root,COG1804@2|Bacteria,2GKNX@201174|Actinobacteria 201174|Actinobacteria C L-carnitine dehydratase bile acid-inducible protein F mcr - 5.1.99.4 ko:K01796 ko00120,ko01100,ko04146,map00120,map01100,map04146 M00104 R08734,R08739 RC02345 ko00000,ko00001,ko00002,ko01000 - - - CoA_transf_3 k59_1019422_1 876044.IMCC3088_857 1.46e-41 149.0 COG2304@1|root,COG2304@2|Bacteria,1QBPM@1224|Proteobacteria,1RQIU@1236|Gammaproteobacteria,1J4PZ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Secreted protein, containing von Willebrand factor (VWF) type - - - - - - - - - - - - - k59_1075412_1 983544.Lacal_2763 2.07e-24 101.0 COG1858@1|root,COG1858@2|Bacteria,4NE50@976|Bacteroidetes,1HYE7@117743|Flavobacteriia 976|Bacteroidetes P cytochrome C peroxidase - - 1.11.1.5 ko:K00428 - - - - ko00000,ko01000 - - - CCP_MauG k59_1019435_1 1122137.AQXF01000003_gene2020 6e-22 92.4 COG0462@1|root,COG0462@2|Bacteria,1MW21@1224|Proteobacteria,2TR4Y@28211|Alphaproteobacteria 28211|Alphaproteobacteria F Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) prs - 2.7.6.1 ko:K00948 ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230 M00005 R01049 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - Pribosyl_synth,Pribosyltran,Pribosyltran_N k59_1471226_1 388413.ALPR1_05670 6.7e-81 258.0 COG3653@1|root,COG3653@2|Bacteria,4NHDD@976|Bacteroidetes,47KC3@768503|Cytophagia 976|Bacteroidetes Q PFAM D-aminoacylase, C-terminal region - - 3.5.1.81 ko:K06015 - - R02192 RC00064,RC00328 ko00000,ko01000 - - - Amidohydro_3 k59_510660_1 983545.Glaag_3394 5.91e-34 125.0 COG0202@1|root,COG0202@2|Bacteria,1MU75@1224|Proteobacteria,1RMU3@1236|Gammaproteobacteria,464HA@72275|Alteromonadaceae 1236|Gammaproteobacteria K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoA GO:0003674,GO:0003824,GO:0003899,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006354,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576 2.7.7.6 ko:K03040 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_A_CTD,RNA_pol_A_bac,RNA_pol_L k59_510660_2 1269813.ATUL01000034_gene1198 2.44e-22 91.7 COG0522@1|root,COG0522@2|Bacteria,1MW0U@1224|Proteobacteria,1RQ38@1236|Gammaproteobacteria,1WW34@135613|Chromatiales 135613|Chromatiales J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit rpsD - - ko:K02986 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S4,S4 k59_2236_1 436308.Nmar_1408 3.66e-27 109.0 COG1389@1|root,arCOG01165@2157|Archaea,41SJ2@651137|Thaumarchaeota 651137|Thaumarchaeota L Relaxes both positive and negative superturns and exhibits a strong decatenase activity top6B - 5.99.1.3 ko:K03167 - - - - ko00000,ko01000,ko03032 - - - HATPase_c,Topo-VIb_trans k59_2236_2 1229909.NSED_07730 2.05e-136 394.0 COG1697@1|root,arCOG04143@2157|Archaea,41SQF@651137|Thaumarchaeota 651137|Thaumarchaeota L Relaxes both positive and negative superturns and exhibits a strong decatenase activity top6A - 5.99.1.3 ko:K03166 - - - - ko00000,ko01000,ko03032 - - - TP6A_N k59_1245300_1 396588.Tgr7_1711 4.41e-25 99.4 COG3439@1|root,COG3439@2|Bacteria,1NDB7@1224|Proteobacteria,1SUXB@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Domain of unknown function DUF302 - - - - - - - - - - - - DUF302 k59_1245300_2 765911.Thivi_4352 6.59e-26 107.0 COG4398@1|root,COG4398@2|Bacteria,1MUX9@1224|Proteobacteria,1RPGR@1236|Gammaproteobacteria,1WWYY@135613|Chromatiales 135613|Chromatiales S FIST N domain - - - - - - - - - - - - FIST,FIST_C k59_284969_1 1129794.C427_4815 4.15e-14 71.6 COG2866@1|root,COG2866@2|Bacteria,1N9W9@1224|Proteobacteria,1RPC7@1236|Gammaproteobacteria,4655X@72275|Alteromonadaceae 1236|Gammaproteobacteria M Zinc carboxypeptidase - - - - - - - - - - - - Peptidase_M14 k59_284969_2 1122137.AQXF01000003_gene2305 3.03e-155 443.0 COG0111@1|root,COG0111@2|Bacteria,1MW1U@1224|Proteobacteria,2TSUU@28211|Alphaproteobacteria 28211|Alphaproteobacteria EH D-isomer specific 2-hydroxyacid dehydrogenase MA20_04115 - 1.1.1.79,1.1.1.81 ko:K12972 ko00260,ko00620,ko00630,ko01100,ko01110,ko01120,map00260,map00620,map00630,map01100,map01110,map01120 - R00465,R01388,R01392,R02527 RC00031,RC00042,RC00670 ko00000,ko00001,ko01000 - - - 2-Hacid_dh_C k59_284969_3 1122137.AQXF01000003_gene2304 1.8e-30 116.0 COG0530@1|root,COG0530@2|Bacteria,1MU3R@1224|Proteobacteria,2TST5@28211|Alphaproteobacteria 28211|Alphaproteobacteria P COG0530 Ca2 Na antiporter - - - ko:K07301 - - - - ko00000,ko02000 2.A.19.5 - - Na_Ca_ex k59_2238_2 1240349.ANGC01000004_gene1728 4.51e-72 231.0 COG0861@1|root,COG0861@2|Bacteria,2GIWU@201174|Actinobacteria,4FUZ0@85025|Nocardiaceae 201174|Actinobacteria P Integral membrane protein TerC family - - - ko:K05794 - - - - ko00000 - - - TerC k59_1245305_1 572477.Alvin_3094 1.3e-20 90.9 COG3344@1|root,COG3344@2|Bacteria,1RD41@1224|Proteobacteria,1SASD@1236|Gammaproteobacteria,1WZT3@135613|Chromatiales 135613|Chromatiales L Reverse transcriptase (RNA-dependent DNA polymerase) - - - - - - - - - - - - RVT_1 k59_1640712_1 391603.FBALC1_10072 7.37e-76 236.0 COG0324@1|root,COG0324@2|Bacteria,4NEAE@976|Bacteroidetes,1HXKT@117743|Flavobacteriia 976|Bacteroidetes J Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) miaA GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016765,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0052381,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.5.1.75 ko:K00791 ko00908,ko01100,ko01110,map00908,map01100,map01110 - R01122 RC02820 ko00000,ko00001,ko01000,ko01006,ko03016 - - - IPPT k59_510687_1 314275.MADE_1002875 4.7e-61 201.0 COG3004@1|root,COG3004@2|Bacteria,1MW15@1224|Proteobacteria,1RNDE@1236|Gammaproteobacteria,465KF@72275|Alteromonadaceae 1236|Gammaproteobacteria P Na( ) H( ) antiporter that extrudes sodium in exchange for external protons nhaA - - ko:K03313 - - - - ko00000,ko02000 2.A.33.1 - - Na_H_antiport_1 k59_1414638_1 1282360.ABAC460_22760 1.33e-72 228.0 COG1414@1|root,COG1414@2|Bacteria,1MUNW@1224|Proteobacteria,2TSY8@28211|Alphaproteobacteria 28211|Alphaproteobacteria K transcriptional regulator iclR - - ko:K13641 - - - - ko00000,ko03000 - - - HTH_IclR,IclR k59_849758_1 987059.RBXJA2T_09297 1.03e-92 296.0 COG0525@1|root,COG0525@2|Bacteria,1MV7B@1224|Proteobacteria,2VH5Z@28216|Betaproteobacteria,1KJN2@119065|unclassified Burkholderiales 28216|Betaproteobacteria J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner valS - 6.1.1.9 ko:K01873 ko00970,map00970 M00359,M00360 R03665 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1 k59_59062_1 926564.KI911603_gene5745 1.53e-75 235.0 COG2089@1|root,COG2089@2|Bacteria,2GJC9@201174|Actinobacteria,4F5PJ@85017|Promicromonosporaceae 201174|Actinobacteria M NeuB family - - 2.5.1.56 ko:K01654 ko00520,ko01100,map00520,map01100 - R01804,R04435 RC00159 ko00000,ko00001,ko01000 - - - CTP_transf_3,NeuB k59_115618_1 1043493.BBLU01000004_gene2674 3.49e-41 147.0 COG2084@1|root,COG2084@2|Bacteria,2ICA7@201174|Actinobacteria 201174|Actinobacteria I 6-phosphogluconate dehydrogenase - - - - - - - - - - - - DUF1932,NAD_binding_2 k59_1527688_1 713586.KB900536_gene2892 3.02e-133 383.0 COG1469@1|root,COG1469@2|Bacteria,1MV1B@1224|Proteobacteria,1RNDY@1236|Gammaproteobacteria,1WW3H@135613|Chromatiales 135613|Chromatiales S Converts GTP to 7,8-dihydroneopterin triphosphate folE2 - 3.5.4.16 ko:K09007 ko00790,ko01100,map00790,map01100 M00126 R00428,R04639,R05046,R05048 RC00263,RC00294,RC00323,RC00945,RC01188 ko00000,ko00001,ko00002,ko01000 - - - GCHY-1 k59_962706_1 1002672.SAR11G3_00822 2.74e-20 90.5 COG3181@1|root,COG3181@2|Bacteria,1PHI8@1224|Proteobacteria,2V8Q7@28211|Alphaproteobacteria,4BT4N@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria S Tripartite tricarboxylate transporter family receptor - - - - - - - - - - - - TctC k59_1188716_1 557599.MKAN_29065 1.08e-47 168.0 COG4638@1|root,COG4638@2|Bacteria,2GM3P@201174|Actinobacteria,233JP@1762|Mycobacteriaceae 201174|Actinobacteria P Ring hydroxylating alpha subunit (catalytic domain) - - - - - - - - - - - - Rieske,Ring_hydroxyl_A k59_567509_1 1122137.AQXF01000003_gene2451 2.91e-81 261.0 COG0642@1|root,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,2TRHH@28211|Alphaproteobacteria 28211|Alphaproteobacteria T Histidine kinase - - 2.7.13.3 ko:K07716 ko02020,ko04112,map02020,map04112 M00511 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - CHASE,GAF_2,HATPase_c,HisKA,Hpt,PAS,PAS_3,PAS_4,PAS_7,PAS_9,Response_reg k59_59082_1 1229909.NSED_07065 1.19e-62 204.0 COG1027@1|root,arCOG01750@2157|Archaea,41S9C@651137|Thaumarchaeota 651137|Thaumarchaeota E Fumarase C C-terminus - - 4.3.1.1 ko:K01744 ko00250,ko01100,map00250,map01100 - R00490 RC00316,RC02799 ko00000,ko00001,ko01000 - - - FumaraseC_C,Lyase_1 k59_59082_2 436308.Nmar_1261 7.94e-33 123.0 COG0621@1|root,arCOG01358@2157|Archaea,41SB9@651137|Thaumarchaeota 651137|Thaumarchaeota J MiaB-like tRNA modifying enzyme - - 2.8.4.5 ko:K15865 - - R10649 RC00003,RC03221 ko00000,ko01000,ko03016 - - - Radical_SAM,UPF0004 k59_2281_2 465541.ATCJ01000005_gene2058 1.76e-67 218.0 COG1819@1|root,COG1819@2|Bacteria,2GJN7@201174|Actinobacteria 201174|Actinobacteria CG Glycosyltransferase, MGT family - - - - - - - - - - - - UDPGT k59_228221_1 990073.ATHU01000001_gene1804 4.49e-136 408.0 COG0480@1|root,COG0480@2|Bacteria,1MUCV@1224|Proteobacteria,42M4T@68525|delta/epsilon subdivisions,2YMB2@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome fusA - - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2 k59_228221_2 1121948.AUAC01000001_gene2947 5.12e-54 174.0 COG0049@1|root,COG0049@2|Bacteria,1MXC8@1224|Proteobacteria,2TSI8@28211|Alphaproteobacteria,43XE5@69657|Hyphomonadaceae 28211|Alphaproteobacteria J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA rpsG GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02992 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S7 k59_1019506_1 1249627.D779_0832 5.69e-82 255.0 COG0448@1|root,COG0448@2|Bacteria,1MVTC@1224|Proteobacteria,1RP04@1236|Gammaproteobacteria,1WW77@135613|Chromatiales 135613|Chromatiales H Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans glgC - 2.7.7.27 ko:K00975 ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026 M00565 R00948 RC00002 ko00000,ko00001,ko00002,ko01000 - - - Hexapep,NTP_transferase k59_1471261_1 436308.Nmar_1715 9.93e-91 274.0 COG1522@1|root,arCOG01586@2157|Archaea,41T3N@651137|Thaumarchaeota 651137|Thaumarchaeota K AsnC-type helix-turn-helix domain - - - - - - - - - - - - HTH_24 k59_1471261_2 436308.Nmar_1716 2.24e-53 171.0 COG0494@1|root,arCOG01073@2157|Archaea,41T73@651137|Thaumarchaeota 651137|Thaumarchaeota L COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes - - 3.6.1.13 ko:K01515 ko00230,map00230 - R01054 RC00002 ko00000,ko00001,ko01000 - - - NUDIX k59_1301872_1 1279017.AQYJ01000029_gene3659 5.26e-91 273.0 28HGI@1|root,2Z7SC@2|Bacteria,1MWKC@1224|Proteobacteria,1SM99@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_172012_1 13690.CP98_01799 8.27e-60 194.0 COG1028@1|root,COG1028@2|Bacteria,1P9R4@1224|Proteobacteria,2TTJ5@28211|Alphaproteobacteria,2K3ZT@204457|Sphingomonadales 204457|Sphingomonadales IQ Enoyl-(Acyl carrier protein) reductase - - - - - - - - - - - - adh_short k59_623752_1 472759.Nhal_3280 9.85e-43 152.0 COG0004@1|root,COG0004@2|Bacteria,1NR9F@1224|Proteobacteria,1RNKF@1236|Gammaproteobacteria,1WWG6@135613|Chromatiales 135613|Chromatiales P Ammonium transporter - - - ko:K03320 - - - - ko00000,ko02000 1.A.11 - - Ammonium_transp k59_59089_1 1279038.KB907350_gene2853 1.73e-14 75.1 COG0518@1|root,COG0518@2|Bacteria,1MV9U@1224|Proteobacteria,2TUIN@28211|Alphaproteobacteria,2JT5B@204441|Rhodospirillales 204441|Rhodospirillales F Glutamine amidotransferase class-I - - 6.3.5.2 ko:K01951 ko00230,ko00983,ko01100,map00230,map00983,map01100 M00050 R01230,R01231,R08244 RC00010,RC00204 ko00000,ko00001,ko00002,ko01000,ko01002 - - - GATase k59_1188733_1 1535422.ND16A_1363 3.89e-85 272.0 28HMZ@1|root,2Z7WD@2|Bacteria,1MU3Q@1224|Proteobacteria,1RRUM@1236|Gammaproteobacteria,2Q6Y5@267889|Colwelliaceae 1236|Gammaproteobacteria S Protein of unknown function (DUF3604) - - - - - - - - - - - - DUF3604 k59_1414669_1 685035.ADAE01000002_gene2305 3.49e-38 136.0 2BU6D@1|root,32PFJ@2|Bacteria,1ND8K@1224|Proteobacteria,2UG2P@28211|Alphaproteobacteria,2K2I2@204457|Sphingomonadales 204457|Sphingomonadales - - - - - - - - - - - - - - - k59_1414669_2 1096930.L284_06845 1.51e-47 163.0 COG2230@1|root,COG2230@2|Bacteria,1MX3U@1224|Proteobacteria,2TR8K@28211|Alphaproteobacteria,2K0PR@204457|Sphingomonadales 204457|Sphingomonadales M synthase - - 2.1.1.79 ko:K00574 - - - - ko00000,ko01000 - - - CMAS k59_59100_1 13690.CP98_04433 2.57e-71 221.0 COG1309@1|root,COG1309@2|Bacteria,1N28W@1224|Proteobacteria,2VEWR@28211|Alphaproteobacteria,2KAFP@204457|Sphingomonadales 204457|Sphingomonadales K Bacterial regulatory proteins, tetR family - - - - - - - - - - - - TetR_N k59_1246331_1 1201293.AKXQ01000004_gene2321 1.09e-109 322.0 28J5X@1|root,2Z91N@2|Bacteria,1R6ZN@1224|Proteobacteria,1S501@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_1359287_1 1122137.AQXF01000003_gene1891 3.31e-165 477.0 COG1511@1|root,COG1511@2|Bacteria,1NYJB@1224|Proteobacteria,2TSX0@28211|Alphaproteobacteria 28211|Alphaproteobacteria S MotA TolQ ExbB proton channel family MA20_18055 - - - - - - - - - - - MotA_ExbB k59_511659_1 1005048.CFU_2572 2.14e-61 214.0 COG4642@1|root,COG4642@2|Bacteria,1P07C@1224|Proteobacteria,2WGN2@28216|Betaproteobacteria,4765J@75682|Oxalobacteraceae 28216|Betaproteobacteria S Peptidase C13 family - - - - - - - - - - - - MORN,Peptidase_C13 k59_342550_1 326442.PSHAa1920 2.01e-94 298.0 COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,1RPM5@1236|Gammaproteobacteria,2Q1PF@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria I COG1960 Acyl-CoA dehydrogenases fadE - 1.3.8.7 ko:K00249,ko:K06445 ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320 M00013,M00036,M00087 R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754 RC00052,RC00068,RC00076,RC00095,RC00148,RC00246 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N,DUF1974 k59_568387_1 1120972.AUMH01000002_gene2761 3.86e-45 159.0 2C1EV@1|root,33RW1@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - Cupin_2 k59_60142_1 439235.Dalk_3445 1.1e-13 75.9 COG1502@1|root,COG1502@2|Bacteria,1MWUW@1224|Proteobacteria,42PV9@68525|delta/epsilon subdivisions,2WKF2@28221|Deltaproteobacteria,2MJW6@213118|Desulfobacterales 28221|Deltaproteobacteria I Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol cls - - ko:K06131 ko00564,ko01100,map00564,map01100 - R07390 RC00017 ko00000,ko00001,ko01000 - - - PLDc_2,PLDc_N k59_1076455_1 59931.WH7805_10653 4.65e-08 60.1 COG2931@1|root,COG3210@1|root,COG4932@1|root,COG5184@1|root,COG2931@2|Bacteria,COG3210@2|Bacteria,COG4932@2|Bacteria,COG5184@2|Bacteria,1GBCU@1117|Cyanobacteria 1117|Cyanobacteria DMQZ amine dehydrogenase activity - - - - - - - - - - - - He_PIG,HemolysinCabind k59_511674_1 467661.RKLH11_3619 9.44e-61 202.0 COG0845@1|root,COG0845@2|Bacteria,1MUI8@1224|Proteobacteria,2TTX9@28211|Alphaproteobacteria 28211|Alphaproteobacteria M type I secretion membrane fusion protein, HlyD family hlyD - - ko:K02022,ko:K11003 ko03070,ko05133,map03070,map05133 M00325,M00575 - - ko00000,ko00001,ko00002,ko02000,ko02044 8.A.1.3.1,8.A.1.3.2 - - Biotin_lipoyl_2,HlyD,HlyD_3 k59_681200_1 316407.85675009 1.85e-121 349.0 COG2095@1|root,COG2095@2|Bacteria,1MV1C@1224|Proteobacteria,1RPM8@1236|Gammaproteobacteria,3XNYA@561|Escherichia 1236|Gammaproteobacteria U MarC family integral membrane protein marC GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944 - ko:K05595 - - - - ko00000,ko02000 2.A.95.1 - - MarC k59_748661_3 436308.Nmar_0684 2.45e-59 193.0 COG1163@1|root,arCOG00358@2157|Archaea,41SAD@651137|Thaumarchaeota 651137|Thaumarchaeota S small GTP-binding protein - - - ko:K06944 - - - - ko00000 - - - MMR_HSR1,MMR_HSR1_Xtn,TGS k59_522439_1 158500.BV97_00881 6.21e-83 257.0 COG2271@1|root,COG2271@2|Bacteria,1QWE8@1224|Proteobacteria,2TWWX@28211|Alphaproteobacteria,2KEEN@204457|Sphingomonadales 204457|Sphingomonadales G Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 k59_1201064_1 1144305.PMI02_00835 8.06e-92 283.0 COG0277@1|root,COG0277@2|Bacteria,1N22A@1224|Proteobacteria,2UR6U@28211|Alphaproteobacteria,2K8UG@204457|Sphingomonadales 204457|Sphingomonadales C FAD binding domain - - - - - - - - - - - - FAD_binding_4 k59_1484310_2 28072.Nos7524_2763 3.42e-09 57.8 COG0517@1|root,COG1994@1|root,COG0517@2|Bacteria,COG1994@2|Bacteria,1GC0N@1117|Cyanobacteria,1HR0M@1161|Nostocales 1117|Cyanobacteria S Belongs to the peptidase M50B family - - - - - - - - - - - - CBS,Peptidase_M50 k59_748665_1 595460.RRSWK_06761 2.5e-57 197.0 COG0840@1|root,COG0840@2|Bacteria,2IXQA@203682|Planctomycetes 203682|Planctomycetes NT Methyl-accepting chemotaxis protein (MCP) signaling domain - - - ko:K02660,ko:K03406 ko02020,ko02025,ko02030,map02020,map02025,map02030 - - - ko00000,ko00001,ko02035,ko02044 - - - Globin,HAMP,MCPsignal,PAS_3,PAS_4,PAS_9 k59_14943_1 518766.Rmar_2759 3.68e-08 60.5 COG0642@1|root,COG2203@1|root,COG3829@1|root,COG2203@2|Bacteria,COG2205@2|Bacteria,COG3829@2|Bacteria,4NDXU@976|Bacteroidetes,1FKEN@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes T Domain present in phytochromes and cGMP-specific phosphodiesterases. - - - - - - - - - - - - GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg k59_692409_1 1121898.Q766_14480 1.32e-78 241.0 COG3741@1|root,COG3741@2|Bacteria,4NIN9@976|Bacteroidetes,1I0JT@117743|Flavobacteriia,2NY9I@237|Flavobacterium 976|Bacteroidetes E N-formylglutamate amidohydrolase - - - - - - - - - - - - FGase k59_297697_1 1088721.NSU_4405 1.94e-56 186.0 COG1792@1|root,COG1792@2|Bacteria,1N8ZS@1224|Proteobacteria,2U1FY@28211|Alphaproteobacteria,2K18A@204457|Sphingomonadales 204457|Sphingomonadales M Involved in formation and maintenance of cell shape mreC - - ko:K03570 - - - - ko00000,ko03036 9.B.157.1 - - MreC k59_1087829_1 765911.Thivi_0673 6.82e-19 94.0 COG0642@1|root,COG0784@1|root,COG2198@1|root,COG2202@1|root,COG2203@1|root,COG2984@1|root,COG3290@1|root,COG0784@2|Bacteria,COG2198@2|Bacteria,COG2202@2|Bacteria,COG2203@2|Bacteria,COG2205@2|Bacteria,COG2984@2|Bacteria,COG3290@2|Bacteria,1NRP8@1224|Proteobacteria,1SKTW@1236|Gammaproteobacteria 1236|Gammaproteobacteria T Histidine kinase - - 2.7.13.3 ko:K10715,ko:K20974 ko02020,ko02024,ko02025,map02020,map02024,map02025 M00517,M00820 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - CHASE,GAF,GAF_2,HATPase_c,HisKA,Hpt,PAS,PAS_3,PAS_4,PAS_9,Response_reg k59_692419_1 1432050.IE4771_CH03223 1.99e-72 241.0 COG2114@1|root,COG4192@1|root,COG2114@2|Bacteria,COG4192@2|Bacteria,1MV1V@1224|Proteobacteria,2U2BQ@28211|Alphaproteobacteria,4BN8Y@82115|Rhizobiaceae 28211|Alphaproteobacteria T PAS fold - - 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 - - - Guanylate_cyc,HAMP,PAS_7 k59_71915_1 395495.Lcho_4151 8.38e-15 73.6 COG2801@1|root,COG2801@2|Bacteria,1PBHA@1224|Proteobacteria,2VKPT@28216|Betaproteobacteria 28216|Betaproteobacteria L PFAM Integrase catalytic region - - - - - - - - - - - - HTH_32,rve,rve_3 k59_71915_3 1366050.N234_09860 2.62e-26 104.0 COG1484@1|root,COG1484@2|Bacteria,1MWQX@1224|Proteobacteria,2VKCG@28216|Betaproteobacteria,1KH23@119060|Burkholderiaceae 28216|Betaproteobacteria L IstB-like ATP binding protein - - - - - - - - - - - - IstB_IS21 k59_354227_2 292415.Tbd_0095 1.68e-33 128.0 COG1236@1|root,COG1236@2|Bacteria,1MUDD@1224|Proteobacteria,2VHFX@28216|Betaproteobacteria,1KRG4@119069|Hydrogenophilales 119069|Hydrogenophilales J Beta-Casp domain - - - ko:K07576 - - - - ko00000 - - - Beta-Casp,Lactamase_B,RMMBL k59_974122_1 1122134.KB893650_gene1320 3.99e-06 47.4 COG0678@1|root,COG0678@2|Bacteria,1MU0H@1224|Proteobacteria,1RRFB@1236|Gammaproteobacteria,1XK41@135619|Oceanospirillales 135619|Oceanospirillales O Peroxiredoxin - - - - - - - - - - - - Redoxin k59_974122_2 1244869.H261_08073 5.99e-60 194.0 COG0604@1|root,COG0604@2|Bacteria,1MWBD@1224|Proteobacteria,2TS3Z@28211|Alphaproteobacteria,2JQBK@204441|Rhodospirillales 204441|Rhodospirillales C COG0604 NADPH quinone reductase and related Zn-dependent oxidoreductases - - 1.6.5.5 ko:K00344 - - - - ko00000,ko01000 - - - ADH_N,ADH_zinc_N k59_1596295_2 314254.OA2633_01696 0.000332 43.1 COG4206@1|root,COG4206@2|Bacteria,1QUGQ@1224|Proteobacteria,2TXTZ@28211|Alphaproteobacteria,440TH@69657|Hyphomonadaceae 28211|Alphaproteobacteria H TonB dependent receptor - - - - - - - - - - - - Plug,TonB_dep_Rec k59_240307_1 1282360.ABAC460_15075 1.72e-49 171.0 COG1680@1|root,COG1680@2|Bacteria,1P3SQ@1224|Proteobacteria,2TTI5@28211|Alphaproteobacteria,2KGKC@204458|Caulobacterales 204458|Caulobacterales V Beta-lactamase - - - - - - - - - - - - Beta-lactamase k59_1426690_1 1280953.HOC_13888 3.6e-33 136.0 COG1629@1|root,COG1629@2|Bacteria,1QYXR@1224|Proteobacteria,2TY0Y@28211|Alphaproteobacteria 28211|Alphaproteobacteria P TonB dependent receptor - - - - - - - - - - - - Plug,TonB_dep_Rec k59_354237_1 436308.Nmar_0670 5.8e-120 349.0 COG0031@1|root,arCOG01430@2157|Archaea,41SYM@651137|Thaumarchaeota 651137|Thaumarchaeota E Cysteine synthase - - 2.5.1.47 ko:K12339 ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230 M00021 R00897,R03132,R03601,R04859 RC00020,RC02814,RC02821,RC02876 ko00000,ko00001,ko00002,ko01000 - - - PALP k59_297737_1 443143.GM18_0559 7.96e-44 160.0 COG1502@1|root,COG1502@2|Bacteria,1MWUW@1224|Proteobacteria,42PV9@68525|delta/epsilon subdivisions,2WJ1M@28221|Deltaproteobacteria,43S7W@69541|Desulfuromonadales 28221|Deltaproteobacteria I Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol cls-2 - - ko:K06131 ko00564,ko01100,map00564,map01100 - R07390 RC00017 ko00000,ko00001,ko01000 - - - PLDc_2,PLDc_N k59_748712_1 396588.Tgr7_2901 5.87e-77 253.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,1RMH0@1236|Gammaproteobacteria,1X29W@135613|Chromatiales 135613|Chromatiales NT chemotaxis - - - ko:K02660 ko02020,ko02025,map02020,map02025 - - - ko00000,ko00001,ko02035,ko02044 - - - MCPsignal,PilJ k59_240325_1 702113.PP1Y_AT29354 2.85e-107 315.0 COG0483@1|root,COG0483@2|Bacteria,1NFR1@1224|Proteobacteria,2U6EN@28211|Alphaproteobacteria,2KE1D@204457|Sphingomonadales 204457|Sphingomonadales G Inositol monophosphatase - - - - - - - - - - - - Inositol_P k59_1257311_1 795666.MW7_0853 6.56e-104 307.0 COG0036@1|root,COG0036@2|Bacteria,1MUZM@1224|Proteobacteria,2VIGU@28216|Betaproteobacteria,1K6PJ@119060|Burkholderiaceae 28216|Betaproteobacteria F Belongs to the ribulose-phosphate 3-epimerase family rpe - 5.1.3.1 ko:K01783 ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007 R01529 RC00540 ko00000,ko00001,ko00002,ko01000 - - - Ribul_P_3_epim k59_1370983_1 1215114.BBIU01000016_gene2394 1.14e-23 93.2 COG2901@1|root,COG2901@2|Bacteria,1N7MJ@1224|Proteobacteria,1SD35@1236|Gammaproteobacteria 1236|Gammaproteobacteria K Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters fis GO:0000018,GO:0000229,GO:0000785,GO:0000786,GO:0000787,GO:0000789,GO:0000976,GO:0000984,GO:0000985,GO:0001017,GO:0001046,GO:0001047,GO:0001067,GO:0001121,GO:0001130,GO:0001131,GO:0001140,GO:0001216,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005694,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008301,GO:0009058,GO:0009059,GO:0009314,GO:0009628,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0016032,GO:0016070,GO:0018130,GO:0019042,GO:0019045,GO:0019046,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0031421,GO:0032359,GO:0032774,GO:0032991,GO:0032993,GO:0034641,GO:0034645,GO:0034654,GO:0042802,GO:0042803,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043565,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044374,GO:0044403,GO:0044419,GO:0044422,GO:0044424,GO:0044427,GO:0044444,GO:0044446,GO:0044464,GO:0044815,GO:0045892,GO:0045893,GO:0045911,GO:0045934,GO:0045935,GO:0046483,GO:0046983,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051054,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0051704,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2001141 - ko:K03557 ko05111,map05111 - - - ko00000,ko00001,ko03000,ko03036,ko03400 - - - HTH_8 k59_1370983_2 228410.NE0874 9.78e-14 70.9 COG0042@1|root,COG0042@2|Bacteria,1MV5V@1224|Proteobacteria,2VHBP@28216|Betaproteobacteria,371XV@32003|Nitrosomonadales 28216|Betaproteobacteria J Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines dusB - - ko:K05540 - - - - ko00000,ko01000,ko03016 - - - Dus k59_1540369_1 713586.KB900536_gene1755 7.52e-66 213.0 COG1194@1|root,COG1194@2|Bacteria,1MUD4@1224|Proteobacteria,1RMBT@1236|Gammaproteobacteria,1WW1U@135613|Chromatiales 135613|Chromatiales L TIGRFAM A G-specific adenine glycosylase - - - ko:K03575 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - HhH-GPD,NUDIX_4 k59_354254_1 887898.HMPREF0551_1667 5.44e-24 100.0 COG0642@1|root,COG0642@2|Bacteria,1PA1G@1224|Proteobacteria,2VHX5@28216|Betaproteobacteria,1K2MI@119060|Burkholderiaceae 28216|Betaproteobacteria T histidine kinase HAMP region domain protein - - 2.7.13.1 ko:K05962 - - - - ko00000,ko01000 - - - HAMP,HATPase_c,HisKA k59_354254_2 1163617.SCD_n01782 1.28e-08 55.8 COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,2VKJ8@28216|Betaproteobacteria 28216|Betaproteobacteria KLT serine threonine protein kinase - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - PEGA,Pkinase k59_974152_1 95619.PM1_0218040 7.1e-34 134.0 COG0642@1|root,COG0784@1|root,COG5002@1|root,COG0784@2|Bacteria,COG2205@2|Bacteria,COG5002@2|Bacteria,1NRP8@1224|Proteobacteria,1SKTW@1236|Gammaproteobacteria 1236|Gammaproteobacteria T Histidine kinase barA GO:0000155,GO:0000160,GO:0000302,GO:0003674,GO:0003824,GO:0004672,GO:0004673,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006979,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009636,GO:0009927,GO:0009987,GO:0010033,GO:0010035,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016775,GO:0018106,GO:0018193,GO:0018202,GO:0019538,GO:0023014,GO:0023052,GO:0035556,GO:0036211,GO:0042221,GO:0042493,GO:0042542,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0046677,GO:0046777,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0060089,GO:0065007,GO:0070887,GO:0071310,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901700 2.7.13.3 ko:K07678 ko02020,ko02025,ko02026,ko05111,map02020,map02025,map02026,map05111 M00475 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - DUF2222,HAMP,HATPase_c,HisKA,Hpt,Response_reg k59_635947_1 430998.XP_007674553.1 2.68e-10 65.1 COG3509@1|root,2SBTI@2759|Eukaryota,3A15Q@33154|Opisthokonta,3P2F2@4751|Fungi,3QPID@4890|Ascomycota,202X8@147541|Dothideomycetes,3MJ3D@451867|Dothideomycetidae 4751|Fungi Q Carbohydrate esterase family 1 protein - - - - - - - - - - - - Esterase_phd k59_184363_1 75379.Tint_1127 4.03e-58 192.0 COG0745@1|root,COG0745@2|Bacteria,1MY3D@1224|Proteobacteria,2WEGC@28216|Betaproteobacteria,1KPGC@119065|unclassified Burkholderiales 28216|Betaproteobacteria K Transcriptional regulatory protein, C terminal - - - ko:K07659 ko02020,ko02026,map02020,map02026 M00445,M00742,M00743 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Trans_reg_C k59_240340_1 983920.Y88_2864 9.71e-09 55.8 COG1957@1|root,COG1957@2|Bacteria,1MUIW@1224|Proteobacteria,2TSXQ@28211|Alphaproteobacteria,2KBDZ@204457|Sphingomonadales 204457|Sphingomonadales F Inosine-uridine preferring nucleoside hydrolase - - - - - - - - - - - - IU_nuc_hydro k59_240340_2 1123252.ATZF01000013_gene2835 2.11e-20 92.4 COG0524@1|root,COG0524@2|Bacteria,1TQRC@1239|Firmicutes,4HA87@91061|Bacilli,27BXB@186824|Thermoactinomycetaceae 91061|Bacilli G Phosphomethylpyrimidine kinase rbsK - 2.7.1.15 ko:K00852 ko00030,map00030 - R01051,R02750 RC00002,RC00017 ko00000,ko00001,ko01000 - - - PfkB k59_748735_1 1122137.AQXF01000003_gene1934 6.66e-106 317.0 COG0014@1|root,COG0014@2|Bacteria,1MUGJ@1224|Proteobacteria,2TS83@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate proA GO:0003674,GO:0003824,GO:0004350,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0055114 1.2.1.41 ko:K00147 ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230 M00015 R03313 RC00684 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_748735_2 1282362.AEAC466_01085 0.000176 43.9 COG1057@1|root,COG1057@2|Bacteria,1RD0J@1224|Proteobacteria,2U6ZC@28211|Alphaproteobacteria,2KG6Z@204458|Caulobacterales 204458|Caulobacterales H Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) nadD - 2.7.7.18 ko:K00969 ko00760,ko01100,map00760,map01100 M00115 R00137,R03005 RC00002 ko00000,ko00001,ko00002,ko01000 - - - CTP_transf_like k59_1765903_1 384765.SIAM614_06768 6.04e-54 181.0 COG0161@1|root,COG0161@2|Bacteria,1MU2N@1224|Proteobacteria,2TQND@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family - - - - - - - - - - - - Aminotran_3 k59_1653356_1 876044.IMCC3088_2090 1.23e-54 186.0 COG2067@1|root,COG2067@2|Bacteria,1MV7W@1224|Proteobacteria,1RPTU@1236|Gammaproteobacteria 1236|Gammaproteobacteria I long-chain fatty acid transport protein - - - ko:K06076 - - - - ko00000,ko02000 1.B.9 - - Toluene_X k59_1596345_1 1229909.NSED_08835 2.2e-83 250.0 COG1522@1|root,arCOG01117@2157|Archaea 1229909.NSED_08835|- K COG1522 Transcriptional regulators - - - - - - - - - - - - - k59_1540376_2 1260251.SPISAL_05520 4.8e-24 100.0 COG1595@1|root,COG1595@2|Bacteria,1MX7T@1224|Proteobacteria,1RN64@1236|Gammaproteobacteria,1WXBZ@135613|Chromatiales 135613|Chromatiales K Belongs to the sigma-70 factor family. ECF subfamily - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 k59_693488_1 1298593.TOL_1925 1.32e-30 114.0 2BV15@1|root,32QDR@2|Bacteria,1RJ98@1224|Proteobacteria,1RYP4@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Prokaryotic cytochrome b561 - - - - - - - - - - - - Ni_hydr_CYTB k59_693488_2 1217720.ALOX01000011_gene2591 1.34e-13 71.2 COG0583@1|root,COG0583@2|Bacteria,1MVA1@1224|Proteobacteria,2TSUS@28211|Alphaproteobacteria,2JPGK@204441|Rhodospirillales 204441|Rhodospirillales K transcriptional regulator - - - ko:K04761 ko02026,map02026 - - - ko00000,ko00001,ko03000 - - - HTH_1,LysR_substrate k59_1202222_1 380358.XALC_1313 8.55e-26 98.2 COG0271@1|root,COG0271@2|Bacteria,1QCDM@1224|Proteobacteria,1RTFD@1236|Gammaproteobacteria,1X7ES@135614|Xanthomonadales 135614|Xanthomonadales T Belongs to the BolA IbaG family - - - ko:K05527 - - - - ko00000,ko03000 - - - BolA k59_523434_1 194439.CT0399 7.11e-121 350.0 COG0588@1|root,COG0588@2|Bacteria,1FDHF@1090|Chlorobi 1090|Chlorobi F Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate gpmA - 5.4.2.11 ko:K01834 ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko05230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map05230 M00001,M00002,M00003 R01518 RC00536 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - His_Phos_1 k59_523439_1 522306.CAP2UW1_1789 9.28e-30 115.0 COG0109@1|root,COG0109@2|Bacteria,1MW3S@1224|Proteobacteria,2VM89@28216|Betaproteobacteria 28216|Betaproteobacteria O Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group - - 2.5.1.141 ko:K02257 ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714 M00154 R07411 RC01786 ko00000,ko00001,ko00002,ko01000,ko01006,ko03029 - - - UbiA k59_1766931_1 1353276.JADR01000002_gene2324 1e-60 211.0 COG0210@1|root,COG2887@1|root,COG0210@2|Bacteria,COG2887@2|Bacteria,4NFZQ@976|Bacteroidetes,1HWXQ@117743|Flavobacteriia 976|Bacteroidetes L COG3893 Inactivated superfamily I helicase - - - - - - - - - - - - PDDEXK_1 k59_1766937_2 556268.OFAG_00820 4.86e-193 559.0 COG4695@1|root,COG4695@2|Bacteria,1NH3T@1224|Proteobacteria 1224|Proteobacteria S Phage portal protein - - - - - - - - - - - - Phage_Mu_F,Phage_portal k59_467313_1 1005048.CFU_4043 1.05e-104 340.0 COG4206@1|root,COG4206@2|Bacteria,1MUZG@1224|Proteobacteria,2VHP6@28216|Betaproteobacteria,4724W@75682|Oxalobacteraceae 28216|Betaproteobacteria M TonB dependent receptor phuR - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_863977_1 1163617.SCD_n01244 1.3e-12 68.6 COG3317@1|root,COG3317@2|Bacteria,1N670@1224|Proteobacteria,2VHS5@28216|Betaproteobacteria 28216|Betaproteobacteria M (Lipo)protein nlpB - - ko:K07287 - - - - ko00000,ko02000 1.B.33.1 - - Lipoprotein_18 k59_863977_2 323848.Nmul_A1540 4.71e-40 141.0 COG0329@1|root,COG0329@2|Bacteria,1MUCM@1224|Proteobacteria,2VIQ4@28216|Betaproteobacteria,371Q4@32003|Nitrosomonadales 28216|Betaproteobacteria E Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) dapA - 4.3.3.7 ko:K01714 ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00525,M00526,M00527 R10147 RC03062,RC03063 ko00000,ko00001,ko00002,ko01000 - - - DHDPS k59_523458_1 1328313.DS2_07598 7.61e-121 366.0 COG1028@1|root,COG3347@1|root,COG1028@2|Bacteria,COG3347@2|Bacteria,1MWSB@1224|Proteobacteria,1RNTD@1236|Gammaproteobacteria,464KH@72275|Alteromonadaceae 1236|Gammaproteobacteria IQ Class II Aldolase and Adducin N-terminal domain - - - - - - - - - - - - Aldolase_II,adh_short_C2 k59_1033479_1 745014.OMB55_00024820 1.46e-46 173.0 COG1629@1|root,COG4771@2|Bacteria,1MU9K@1224|Proteobacteria,1RMTG@1236|Gammaproteobacteria,1J5SV@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P COG1629 Outer membrane receptor proteins, mostly Fe transport - - - - - - - - - - - - Plug,TonB_dep_Rec k59_1541322_1 448385.sce7469 4.7e-42 163.0 COG1858@1|root,COG3391@1|root,COG1858@2|Bacteria,COG3391@2|Bacteria,1R66T@1224|Proteobacteria 1224|Proteobacteria C amine dehydrogenase activity - - - - - - - - - - - - Lactonase k59_580561_2 1122970.AUHC01000008_gene166 1.15e-33 119.0 2AM98@1|root,31C42@2|Bacteria,1P0FQ@1224|Proteobacteria,2UU32@28211|Alphaproteobacteria,2KB5D@204457|Sphingomonadales 204457|Sphingomonadales - - - - - - - - - - - - - - - k59_580561_3 1380347.JNII01000012_gene2682 6.41e-12 70.1 COG0642@1|root,COG0642@2|Bacteria,COG2205@2|Bacteria,2I2M2@201174|Actinobacteria,4ERVE@85013|Frankiales 201174|Actinobacteria T Histidine Phosphotransfer domain - - - - - - - - - - - - CHASE3,HAMP,HATPase_c,HisKA,Hpt,PAS_4,PAS_9,Response_reg,dCache_1 k59_129062_1 292414.TM1040_1205 1.19e-12 70.1 COG0014@1|root,COG0014@2|Bacteria,1MUGJ@1224|Proteobacteria,2TS83@28211|Alphaproteobacteria,4NBIQ@97050|Ruegeria 28211|Alphaproteobacteria E Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate proA GO:0003674,GO:0003824,GO:0004350,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0055114 1.2.1.41 ko:K00147 ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230 M00015 R03313 RC00684 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_129062_2 1509405.GV67_15260 1.58e-20 90.5 COG0263@1|root,COG0263@2|Bacteria,1MUBG@1224|Proteobacteria,2TRKB@28211|Alphaproteobacteria,4B9BB@82115|Rhizobiaceae 28211|Alphaproteobacteria E Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate proB GO:0003674,GO:0003824,GO:0004349,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0018130,GO:0019202,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.2.11 ko:K00931 ko00330,ko00332,ko01100,ko01130,ko01230,map00330,map00332,map01100,map01130,map01230 M00015 R00239 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase,PUA k59_467324_1 198214.SF3194 1.07e-48 159.0 COG0693@1|root,COG0693@2|Bacteria,1MY0C@1224|Proteobacteria,1S3SC@1236|Gammaproteobacteria 1236|Gammaproteobacteria S intracellular protease yhbO GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006082,GO:0006089,GO:0006139,GO:0006259,GO:0006281,GO:0006464,GO:0006517,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009100,GO:0009266,GO:0009268,GO:0009314,GO:0009408,GO:0009411,GO:0009416,GO:0009438,GO:0009628,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0019172,GO:0019249,GO:0019538,GO:0019752,GO:0030091,GO:0032787,GO:0033554,GO:0034641,GO:0036211,GO:0036524,GO:0036525,GO:0042180,GO:0042182,GO:0042802,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046185,GO:0046394,GO:0046483,GO:0050896,GO:0051596,GO:0051716,GO:0061727,GO:0071704,GO:0072330,GO:0090304,GO:0140096,GO:1901135,GO:1901360,GO:1901564,GO:1901575,GO:1901576,GO:1901615,GO:1901617 3.5.1.124 ko:K05520 - - - - ko00000,ko01000,ko01002 - - - DJ-1_PfpI k59_467324_2 511145.b3152 4.2e-70 215.0 COG0702@1|root,COG0702@2|Bacteria,1MZG7@1224|Proteobacteria,1S39N@1236|Gammaproteobacteria,3XNI7@561|Escherichia 1236|Gammaproteobacteria GM oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor yraR - - - - - - - - - - - HIM1,NAD_binding_10,Semialdhyde_dh k59_1654546_1 49964.Q94MS1_9CAUD 1.18e-58 193.0 4QB4H@10239|Viruses,4QYQI@35237|dsDNA viruses no RNA stage,4QUAR@28883|Caudovirales,4QNUV@10744|Podoviridae 10744|Podoviridae - - - - - - - - - - - - - - - k59_1202271_1 998088.B565_3680 9.18e-81 245.0 COG0288@1|root,COG0288@2|Bacteria,1NGFN@1224|Proteobacteria,1RSY6@1236|Gammaproteobacteria,1Y3SW@135624|Aeromonadales 135624|Aeromonadales P Reversible hydration of carbon dioxide - - 4.2.1.1 ko:K01673 ko00910,map00910 - R00132,R10092 RC02807 ko00000,ko00001,ko01000 - - - Pro_CA k59_298897_1 1260251.SPISAL_04500 6.25e-26 102.0 COG0052@1|root,COG0052@2|Bacteria,1MU33@1224|Proteobacteria,1RN0Z@1236|Gammaproteobacteria,1WW47@135613|Chromatiales 135613|Chromatiales J Belongs to the universal ribosomal protein uS2 family rpsB - - ko:K02967 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S2 k59_298897_2 1269813.ATUL01000015_gene152 8.27e-47 157.0 COG0024@1|root,COG0024@2|Bacteria,1MU99@1224|Proteobacteria,1RMHN@1236|Gammaproteobacteria,1WX9V@135613|Chromatiales 135613|Chromatiales E TIGRFAM methionine aminopeptidase, type I map - 3.4.11.18 ko:K01265 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M24 k59_749925_2 1123242.JH636434_gene4561 1.24e-70 221.0 COG3708@1|root,COG3795@1|root,COG3708@2|Bacteria,COG3795@2|Bacteria,2IZ9F@203682|Planctomycetes 203682|Planctomycetes K PFAM YCII-related - - - - - - - - - - - - YCII k59_467330_1 316407.85676388 1.22e-160 463.0 COG2982@1|root,COG2982@2|Bacteria,1MU7Y@1224|Proteobacteria,1RN96@1236|Gammaproteobacteria,3XMHH@561|Escherichia 1236|Gammaproteobacteria M AsmA family yicH GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - - - - - - - - - - AsmA k59_580590_1 1229909.NSED_09490 1.77e-115 343.0 COG0174@1|root,arCOG01909@2157|Archaea,41SD6@651137|Thaumarchaeota 651137|Thaumarchaeota E TIGRFAM glutamine synthetase, type I - - 6.3.1.2 ko:K01915 ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 - R00253 RC00010,RC02798 ko00000,ko00001,ko01000,ko04147 - - - Gln-synt_C,Gln-synt_N k59_1145219_1 485918.Cpin_0081 4.76e-38 144.0 COG1231@1|root,COG1231@2|Bacteria,4NH02@976|Bacteroidetes 976|Bacteroidetes E Flavin containing amine oxidoreductase - - 1.4.3.4 ko:K00274 ko00260,ko00330,ko00340,ko00350,ko00360,ko00380,ko00950,ko00982,ko01100,ko01110,ko04726,ko04728,ko05030,ko05031,ko05034,map00260,map00330,map00340,map00350,map00360,map00380,map00950,map00982,map01100,map01110,map04726,map04728,map05030,map05031,map05034 M00135 R02173,R02382,R02529,R02532,R02613,R02908,R02919,R04025,R04300,R04674,R04890,R04893,R04894,R04907,R04908,R08346,R08347,R08348,R11354 RC00062,RC00160,RC00225,RC00676,RC00807,RC00808,RC01808,RC02226,RC02713 ko00000,ko00001,ko00002,ko01000 - - - Amino_oxidase k59_298909_1 1537994.JQFW01000015_gene1370 4.05e-49 168.0 COG0115@1|root,COG0115@2|Bacteria,1MVB0@1224|Proteobacteria,1RP6Z@1236|Gammaproteobacteria,465JF@72275|Alteromonadaceae 1236|Gammaproteobacteria EH Branched-chain amino acid aminotransferase ilvE - 2.6.1.42 ko:K00826 ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00036,M00119,M00570 R01090,R01214,R02199,R10991 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_4 k59_693551_1 588581.Cpap_2297 4.4e-27 112.0 COG1472@1|root,COG1472@2|Bacteria,1TP0T@1239|Firmicutes,24932@186801|Clostridia,3WGZR@541000|Ruminococcaceae 186801|Clostridia G Hydrolase Family 3 - - 3.2.1.21 ko:K05349 ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110 - R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040 RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248 ko00000,ko00001,ko01000 - GH3 - Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C k59_476135_1 1415778.JQMM01000001_gene2029 1.7e-116 337.0 COG0009@1|root,COG0009@2|Bacteria,1MVPM@1224|Proteobacteria,1RNU8@1236|Gammaproteobacteria,1J4HA@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Belongs to the SUA5 family yciO GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - - - - - - - - - - Sua5_yciO_yrdC k59_420597_1 1121033.AUCF01000017_gene3878 3.69e-29 120.0 COG2202@1|root,COG4251@1|root,COG2202@2|Bacteria,COG4251@2|Bacteria,1RCM2@1224|Proteobacteria,2URI2@28211|Alphaproteobacteria,2JWH4@204441|Rhodospirillales 204441|Rhodospirillales T Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) - - - - - - - - - - - - HATPase_c,PAS_4 k59_815137_1 95619.PM1_0206350 7.12e-17 75.9 COG1925@1|root,COG1925@2|Bacteria,1N6RM@1224|Proteobacteria 1224|Proteobacteria G phosphocarrier protein hpr ptsH GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0006808,GO:0006810,GO:0008150,GO:0008152,GO:0008643,GO:0009401,GO:0009987,GO:0010033,GO:0010243,GO:0016310,GO:0016740,GO:0016772,GO:0019538,GO:0036211,GO:0042221,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0050789,GO:0050896,GO:0051179,GO:0051234,GO:0065007,GO:0071702,GO:0071704,GO:1901564,GO:1901698 - ko:K08485,ko:K11189 ko02060,map02060 - - - ko00000,ko00001,ko02000 4.A.2.1 - - PTS-HPr k59_815137_2 1453501.JELR01000001_gene3091 7.95e-56 191.0 COG2239@1|root,COG2239@2|Bacteria,1MW24@1224|Proteobacteria,1RNE4@1236|Gammaproteobacteria,4641S@72275|Alteromonadaceae 1236|Gammaproteobacteria P Acts as a magnesium transporter mgtE - - ko:K06213 - - - - ko00000,ko02000 1.A.26.1 - - CBS,MgtE,MgtE_N k59_1774898_1 436308.Nmar_0001 9.24e-96 289.0 COG1474@1|root,arCOG00467@2157|Archaea,41SED@651137|Thaumarchaeota 651137|Thaumarchaeota L Involved in regulation of DNA replication - - - ko:K10725 - - - - ko00000,ko03032 - - - AAA_22,Cdc6_C k59_704234_1 1173027.Mic7113_2151 9.94e-15 77.4 COG0642@1|root,COG0784@1|root,COG2198@1|root,COG2202@1|root,COG0784@2|Bacteria,COG2198@2|Bacteria,COG2202@2|Bacteria,COG2205@2|Bacteria,1G09B@1117|Cyanobacteria,1H82F@1150|Oscillatoriales 1117|Cyanobacteria T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - HATPase_c,HisKA,Hpt,PAS_3,PAS_4,PAS_9,Response_reg k59_83854_1 436308.Nmar_0975 1.53e-49 168.0 COG1602@1|root,arCOG04269@2157|Archaea,41S7H@651137|Thaumarchaeota 651137|Thaumarchaeota S Archaeal Nre, N-terminal - - - - - - - - - - - - Nre_C,Nre_N k59_420604_1 587753.EY04_07155 3.67e-67 210.0 COG0580@1|root,COG0580@2|Bacteria,1MXTJ@1224|Proteobacteria,1RPKU@1236|Gammaproteobacteria 1236|Gammaproteobacteria G Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity aqpZ GO:0003674,GO:0005215,GO:0005372,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006833,GO:0006884,GO:0006950,GO:0006970,GO:0008150,GO:0008361,GO:0009628,GO:0009987,GO:0009992,GO:0015250,GO:0015267,GO:0015318,GO:0016020,GO:0016021,GO:0016043,GO:0019725,GO:0022803,GO:0022838,GO:0022857,GO:0030104,GO:0031224,GO:0031226,GO:0032535,GO:0042044,GO:0042592,GO:0042802,GO:0044425,GO:0044459,GO:0044464,GO:0048878,GO:0050896,GO:0051179,GO:0051234,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0071840,GO:0071944,GO:0090066 - ko:K06188 - - - - ko00000,ko02000 1.A.8 - - MIP k59_1436436_1 1121918.ARWE01000001_gene2929 1.26e-41 156.0 COG1197@1|root,COG1197@2|Bacteria,1MUXG@1224|Proteobacteria,42N8X@68525|delta/epsilon subdivisions,2WIVR@28221|Deltaproteobacteria,43SCA@69541|Desulfuromonadales 28221|Deltaproteobacteria L TRCF mfd - - ko:K03723 ko03420,map03420 - - - ko00000,ko00001,ko01000,ko03400 - - - CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF k59_1212682_1 1380600.AUYN01000006_gene482 1.24e-22 91.7 2CF3S@1|root,321V6@2|Bacteria,4NQGQ@976|Bacteroidetes,1I2Y9@117743|Flavobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_1212682_2 1469557.JSWF01000044_gene684 1.33e-32 121.0 28IUS@1|root,2Z8TF@2|Bacteria,4NIVZ@976|Bacteroidetes,1HXSQ@117743|Flavobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_26754_2 187303.BN69_0155 1.99e-31 114.0 2EBNS@1|root,335NZ@2|Bacteria,1NZKS@1224|Proteobacteria,2UTI5@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_983940_1 1121937.AUHJ01000005_gene2208 4.77e-91 281.0 COG0034@1|root,COG0034@2|Bacteria,1MU0V@1224|Proteobacteria,1RMYA@1236|Gammaproteobacteria,464VT@72275|Alteromonadaceae 1236|Gammaproteobacteria F Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine purF GO:0003674,GO:0003824,GO:0004044,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006163,GO:0006164,GO:0006520,GO:0006541,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009064,GO:0009117,GO:0009165,GO:0009987,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019637,GO:0019752,GO:0034641,GO:0034654,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605 2.4.2.14 ko:K00764 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048 R01072 RC00010,RC02724,RC02752 ko00000,ko00001,ko00002,ko01000,ko01002 - - iAF1260.b2312,iB21_1397.B21_02197,iBWG_1329.BWG_2086,iECBD_1354.ECBD_1347,iECB_1328.ECB_02237,iECDH10B_1368.ECDH10B_2474,iECDH1ME8569_1439.ECDH1ME8569_2250,iECD_1391.ECD_02237,iECIAI1_1343.ECIAI1_2389,iECO103_1326.ECO103_2776,iECO111_1330.ECO111_3060,iECO26_1355.ECO26_3300,iECW_1372.ECW_m2501,iEKO11_1354.EKO11_1453,iETEC_1333.ETEC_2448,iEcDH1_1363.EcDH1_1344,iEcE24377_1341.EcE24377A_2606,iEcolC_1368.EcolC_1340,iJO1366.b2312,iJR904.b2312,iSF_1195.SF2388,iSFxv_1172.SFxv_2633,iSSON_1240.SSON_2370,iS_1188.S2523,iSbBS512_1146.SbBS512_E2690,iUMNK88_1353.UMNK88_2863,iWFL_1372.ECW_m2501,iY75_1357.Y75_RS12125 GATase_6,Pribosyltran k59_983940_2 247634.GPB2148_3561 0.00018 43.1 COG0626@1|root,COG0626@2|Bacteria,1MU57@1224|Proteobacteria,1RMCV@1236|Gammaproteobacteria,1J4WT@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Catalyzes the formation of L-homocysteine from O- succinyl-L-homoserine (OSHS) and hydrogen sulfide metZ - - ko:K10764 ko00270,ko00920,ko01100,map00270,map00920,map01100 - R01288 RC00020,RC02848 ko00000,ko00001,ko01000 - - - Cys_Met_Meta_PP k59_758510_1 349124.Hhal_1221 1.03e-53 187.0 COG0751@1|root,COG0751@2|Bacteria,1MV2F@1224|Proteobacteria,1RNR3@1236|Gammaproteobacteria,1WWSJ@135613|Chromatiales 135613|Chromatiales J Glycyl-tRNA synthetase beta subunit glyS - 6.1.1.14 ko:K01879 ko00970,map00970 M00360 R03654 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DALR_1,tRNA_synt_2f k59_366355_1 392500.Swoo_3072 2.25e-41 154.0 COG4805@1|root,COG4805@2|Bacteria,1MUBX@1224|Proteobacteria,1RMT7@1236|Gammaproteobacteria,2QAJN@267890|Shewanellaceae 1236|Gammaproteobacteria S Bacterial protein of unknown function (DUF885) - - - - - - - - - - - - DUF885 k59_590992_1 997296.PB1_13764 1.02e-42 160.0 COG5001@1|root,COG5001@2|Bacteria,1TP8V@1239|Firmicutes,4HA3G@91061|Bacilli,1ZAVY@1386|Bacillus 91061|Bacilli T Diguanylate cyclase gmr - - - - - - - - - - - EAL,GGDEF,PAS_8,PAS_9 k59_1608566_1 391735.Veis_4064 3.54e-23 100.0 COG3666@1|root,COG3666@2|Bacteria,1N3QR@1224|Proteobacteria,2VWKV@28216|Betaproteobacteria,4AEIE@80864|Comamonadaceae 28216|Betaproteobacteria L PFAM transposase, IS4 family protein - - - - - - - - - - - - DDE_Tnp_1_6,DUF772 k59_1774928_1 887898.HMPREF0551_1387 6.86e-66 216.0 COG0795@1|root,COG0795@2|Bacteria,1MUF2@1224|Proteobacteria,2VH9C@28216|Betaproteobacteria,1JZVZ@119060|Burkholderiaceae 28216|Betaproteobacteria S Permease, YjgP YjgQ family lptF - - ko:K07091 ko02010,map02010 M00320 - - ko00000,ko00001,ko00002,ko02000 1.B.42.1 - - YjgP_YjgQ k59_26778_2 1380380.JIAX01000011_gene2641 1.4e-15 77.8 COG0730@1|root,COG0730@2|Bacteria,1RAG9@1224|Proteobacteria,2VEQZ@28211|Alphaproteobacteria 28211|Alphaproteobacteria S membrane transporter protein - - - - - - - - - - - - TauE k59_83902_2 85643.Tmz1t_0866 8.06e-77 238.0 COG1702@1|root,COG1702@2|Bacteria,1MVDV@1224|Proteobacteria,2VH9V@28216|Betaproteobacteria,2KUF6@206389|Rhodocyclales 206389|Rhodocyclales T phosphate starvation-inducible protein PhoH - - - ko:K06217 - - - - ko00000 - - - PhoH k59_1552598_1 880070.Cycma_4552 7.3e-71 239.0 COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1146@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1146@2|Bacteria,4NF4F@976|Bacteroidetes,47U87@768503|Cytophagia 976|Bacteroidetes C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin nifJ - 1.2.7.1 ko:K03737 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00173,M00307 R01196,R10866 RC00004,RC02742 br01601,ko00000,ko00001,ko00002,ko01000 - - - EKR,Fer4_16,Fer4_7,PFOR_II,POR,POR_N,TPP_enzyme_C k59_758523_1 397945.Aave_1527 3.77e-98 303.0 COG0348@1|root,COG0348@2|Bacteria,1MVFY@1224|Proteobacteria,2VHRH@28216|Betaproteobacteria,4AB30@80864|Comamonadaceae 28216|Betaproteobacteria C PFAM 4Fe-4S ferredoxin iron-sulfur binding domain protein ccoG - - - - - - - - - - - Fer4_18,Fer4_5,FixG_C k59_1436473_1 1120972.AUMH01000021_gene2299 2.55e-54 191.0 COG1984@1|root,COG2049@1|root,COG1984@2|Bacteria,COG2049@2|Bacteria,1TR6U@1239|Firmicutes,4HACC@91061|Bacilli,278QH@186823|Alicyclobacillaceae 91061|Bacilli E Allophanate hydrolase subunit 2 kipA - - ko:K06350 - - - - ko00000 - - - CT_A_B k59_645827_1 326427.Cagg_1451 1.73e-113 341.0 COG0423@1|root,COG0423@2|Bacteria,2G62M@200795|Chloroflexi,376EQ@32061|Chloroflexia 32061|Chloroflexia J Catalyzes the attachment of glycine to tRNA(Gly) glyQS - 6.1.1.14 ko:K01880 ko00970,map00970 M00359,M00360 R03654 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - HGTP_anticodon,tRNA-synt_2b k59_1324067_1 1088721.NSU_4046 4.69e-126 363.0 COG0175@1|root,COG0175@2|Bacteria,1MUCZ@1224|Proteobacteria,2TT2D@28211|Alphaproteobacteria,2K1HF@204457|Sphingomonadales 204457|Sphingomonadales EH sulfate adenylyltransferase cysD - 2.7.7.4 ko:K00957 ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130 M00176,M00596 R00529,R04929 RC02809,RC02889 ko00000,ko00001,ko00002,ko01000 - - - PAPS_reduct k59_875519_4 59374.Fisuc_1256 5.27e-09 56.6 COG2827@1|root,COG2827@2|Bacteria 2|Bacteria L Endonuclease containing a URI domain yhbQ GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004527,GO:0004529,GO:0004536,GO:0006139,GO:0006259,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008296,GO:0008408,GO:0009987,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360 - ko:K07461 - - - - ko00000 - - - GIY-YIG k59_1155797_1 765420.OSCT_2987 3.22e-57 207.0 COG0457@1|root,COG2114@1|root,COG3899@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG3899@2|Bacteria,2G699@200795|Chloroflexi,376QI@32061|Chloroflexia 32061|Chloroflexia T adenylyl cyclase class-3 4 guanylyl cyclase - - - - - - - - - - - - AAA_16,Guanylate_cyc k59_1213472_1 1123354.AUDR01000012_gene1902 6.07e-10 66.2 COG5002@1|root,COG5002@2|Bacteria,1MWF3@1224|Proteobacteria,2VIBV@28216|Betaproteobacteria,1KSVV@119069|Hydrogenophilales 119069|Hydrogenophilales T His Kinase A (phosphoacceptor) domain - - 2.7.13.3 ko:K07636 ko02020,map02020 M00434 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - DUF3329,HATPase_c,HisKA k59_928867_1 316407.1736451 2.66e-119 352.0 COG1760@1|root,COG1760@2|Bacteria,1MUZN@1224|Proteobacteria,1RMJZ@1236|Gammaproteobacteria,3XN8Q@561|Escherichia 1236|Gammaproteobacteria E L-serine dehydratase 1 sdaA GO:0003674,GO:0003824,GO:0003941,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006563,GO:0006565,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009069,GO:0009071,GO:0009987,GO:0016054,GO:0016829,GO:0016840,GO:0016841,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606 4.3.1.17 ko:K01752 ko00260,ko00270,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00270,map01100,map01110,map01130,map01200,map01230 - R00220,R00590 RC00331,RC02600 ko00000,ko00001,ko01000 - - iECSP_1301.ECSP_4084,iECUMN_1333.ECUMN_2106 SDH_alpha,SDH_beta k59_1496999_2 426114.THI_0713 9.26e-23 100.0 COG0845@1|root,COG0845@2|Bacteria,1NWSR@1224|Proteobacteria 1224|Proteobacteria M Evidence 4 Homologs of previously reported genes of - - - ko:K02005 - - - - ko00000 - - - Biotin_lipoyl_2,HlyD_3 k59_367239_1 1088721.NSU_3941 8.9e-75 231.0 COG1159@1|root,COG1159@2|Bacteria,1MUKT@1224|Proteobacteria,2TSHM@28211|Alphaproteobacteria,2K01W@204457|Sphingomonadales 204457|Sphingomonadales S An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism era - - ko:K03595 - - - - ko00000,ko03009,ko03029 - - - KH_2,MMR_HSR1 k59_1609415_1 1449050.JNLE01000003_gene886 4.95e-103 310.0 COG0216@1|root,COG0216@2|Bacteria,1TQ7V@1239|Firmicutes,248CN@186801|Clostridia,36DYV@31979|Clostridiaceae 186801|Clostridia J Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA prfA - - ko:K02835 - - - - ko00000,ko03012 - - - PCRF,RF-1 k59_367241_2 436308.Nmar_1102 2.15e-49 167.0 COG3794@1|root,arCOG06255@1|root,arCOG02926@2157|Archaea,arCOG06255@2157|Archaea 2157|Archaea C PFAM blue (type 1) copper domain protein - - - - - - - - - - - - Copper-bind k59_252547_1 1349822.NSB1T_04080 1.76e-06 53.5 COG1309@1|root,COG1309@2|Bacteria,4NIBT@976|Bacteroidetes,2FT91@200643|Bacteroidia,22YMM@171551|Porphyromonadaceae 976|Bacteroidetes K Transcriptional regulator, TetR family - - - - - - - - - - - - TetR_N k59_27692_1 1283300.ATXB01000001_gene1162 1.09e-198 599.0 COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1145@1|root,COG1146@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1145@2|Bacteria,COG1146@2|Bacteria,1MVM0@1224|Proteobacteria,1RNNX@1236|Gammaproteobacteria,1XE3B@135618|Methylococcales 135618|Methylococcales C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin - - 1.2.7.1 ko:K03737 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00173,M00307 R01196,R10866 RC00004,RC02742 br01601,ko00000,ko00001,ko00002,ko01000 - - - EKR,Fer4_16,PFOR_II,POR,POR_N,TPP_enzyme_C k59_1497006_1 1026882.MAMP_00783 2.78e-82 260.0 COG0758@1|root,COG0758@2|Bacteria,1MVF6@1224|Proteobacteria,1RPJE@1236|Gammaproteobacteria,46093@72273|Thiotrichales 72273|Thiotrichales LU TIGRFAM DNA protecting protein DprA - - - ko:K04096 - - - - ko00000 - - - DNA_processg_A k59_1383591_1 436308.Nmar_0971 3.19e-50 167.0 COG0668@1|root,arCOG01568@2157|Archaea,41T3B@651137|Thaumarchaeota 651137|Thaumarchaeota M Mechanosensitive ion channel - - - - - - - - - - - - MS_channel k59_252551_1 1122622.ATWJ01000010_gene1431 7.32e-68 216.0 2F548@1|root,33XRC@2|Bacteria,2H5BG@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - - k59_1609426_1 247633.GP2143_08905 5.62e-112 347.0 COG1472@1|root,COG1472@2|Bacteria,1MVIV@1224|Proteobacteria,1RMA0@1236|Gammaproteobacteria,1J9QE@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria G Fibronectin type III-like domain bglS - 3.2.1.21 ko:K05349 ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110 - R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040 RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248 ko00000,ko00001,ko01000 - GH3 - Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C k59_252554_1 1379270.AUXF01000001_gene2129 6.59e-48 169.0 COG1304@1|root,COG1304@2|Bacteria,1ZUNQ@142182|Gemmatimonadetes 2|Bacteria C FMN-dependent dehydrogenase - - 1.1.3.15,1.1.3.46 ko:K00104,ko:K16422 ko00261,ko00630,ko01055,ko01100,ko01110,ko01120,ko01130,map00261,map00630,map01055,map01100,map01110,map01120,map01130 - R00475,R06633 RC00042,RC00240 ko00000,ko00001,ko01000 - - - FMN_dh k59_421231_1 199310.c5094 5.37e-43 148.0 COG1879@1|root,COG1879@2|Bacteria,1NP4K@1224|Proteobacteria,1SZUW@1236|Gammaproteobacteria,3XQNK@561|Escherichia 1236|Gammaproteobacteria G D-allose-binding periplasmic protein alsB GO:0003674,GO:0005215,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0008643,GO:0015144,GO:0015145,GO:0015749,GO:0016020,GO:0016021,GO:0022857,GO:0030246,GO:0030288,GO:0030313,GO:0031224,GO:0031975,GO:0034219,GO:0036094,GO:0042597,GO:0044425,GO:0044464,GO:0048029,GO:0051119,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944 - ko:K10549 ko02010,map02010 M00217 - - ko00000,ko00001,ko00002,ko02000 3.A.1.2.6 - iECIAI39_1322.ECIAI39_4512,iECSF_1327.ECSF_3969,iNRG857_1313.NRG857_20510,iUMN146_1321.UM146_20675 Peripla_BP_4 k59_421231_2 316407.85676840 4.71e-46 160.0 COG1129@1|root,COG1129@2|Bacteria,1MU22@1224|Proteobacteria,1RMCH@1236|Gammaproteobacteria,3XQVS@561|Escherichia 1236|Gammaproteobacteria P Part of the ABC transporter complex AlsBAC involved in D-allose import. Probably responsible for energy coupling to the transport system alsA GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005354,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0005996,GO:0006810,GO:0006950,GO:0006974,GO:0008144,GO:0008150,GO:0008152,GO:0008643,GO:0008645,GO:0009987,GO:0015144,GO:0015145,GO:0015146,GO:0015148,GO:0015149,GO:0015399,GO:0015405,GO:0015407,GO:0015591,GO:0015592,GO:0015749,GO:0015750,GO:0015752,GO:0015753,GO:0015757,GO:0015765,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019321,GO:0022804,GO:0022857,GO:0030554,GO:0031224,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033554,GO:0034219,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042732,GO:0043167,GO:0043168,GO:0043190,GO:0043211,GO:0043492,GO:0044238,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051119,GO:0051179,GO:0051234,GO:0051716,GO:0055085,GO:0071702,GO:0071704,GO:0071944,GO:0097159,GO:0097367,GO:0098533,GO:0098796,GO:0098797,GO:1901264,GO:1901265,GO:1901363,GO:1901505,GO:1901656,GO:1902494,GO:1902495,GO:1904949,GO:1990351 3.6.3.17 ko:K02056,ko:K10441,ko:K10542,ko:K10545,ko:K10551 ko02010,map02010 M00212,M00214,M00215,M00217,M00221 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.2,3.A.1.2.1,3.A.1.2.13,3.A.1.2.19,3.A.1.2.3,3.A.1.2.4,3.A.1.2.6 - iEC55989_1330.EC55989_4224,iECED1_1282.ECED1_4821,iECED1_1282.ECED1_5085,iECH74115_1262.ECH74115_3282,iECNA114_1301.ECNA114_4270,iECSE_1348.ECSE_4039,iECSP_1301.ECSP_3027,iECW_1372.ECW_m4052,iEcE24377_1341.EcE24377A_4265,iSF_1195.SF3611,iS_1188.S4158,iWFL_1372.ECW_m4052 ABC_tran k59_310348_1 1380346.JNIH01000050_gene6135 4.67e-39 135.0 COG2030@1|root,COG2030@2|Bacteria,2IHRG@201174|Actinobacteria 201174|Actinobacteria I dehydratase - - - - - - - - - - - - MaoC_dehydratas k59_1383604_1 765910.MARPU_08110 8.64e-21 93.2 COG0354@1|root,COG0354@2|Bacteria,1N852@1224|Proteobacteria,1RPWB@1236|Gammaproteobacteria,1WWK8@135613|Chromatiales 135613|Chromatiales S Belongs to the GcvT family - - - ko:K06980 - - - - ko00000,ko03016 - - - GCV_T,GCV_T_C k59_1383604_2 870187.Thini_0410 8.97e-27 107.0 COG1190@1|root,COG1190@2|Bacteria,1MX1V@1224|Proteobacteria,1RMJN@1236|Gammaproteobacteria,4608H@72273|Thiotrichales 72273|Thiotrichales J Belongs to the class-II aminoacyl-tRNA synthetase family lysS - 6.1.1.6 ko:K04567 ko00970,map00970 M00359,M00360 R03658 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_2,tRNA_anti-codon k59_1497022_1 555793.WSK_0783 7.35e-71 229.0 COG1231@1|root,COG1231@2|Bacteria,1RA9M@1224|Proteobacteria,2TTDV@28211|Alphaproteobacteria,2K25J@204457|Sphingomonadales 204457|Sphingomonadales E Flavin containing amine oxidoreductase - - 1.4.3.4 ko:K00274 ko00260,ko00330,ko00340,ko00350,ko00360,ko00380,ko00950,ko00982,ko01100,ko01110,ko04726,ko04728,ko05030,ko05031,ko05034,map00260,map00330,map00340,map00350,map00360,map00380,map00950,map00982,map01100,map01110,map04726,map04728,map05030,map05031,map05034 M00135 R02173,R02382,R02529,R02532,R02613,R02908,R02919,R04025,R04300,R04674,R04890,R04893,R04894,R04907,R04908,R08346,R08347,R08348,R11354 RC00062,RC00160,RC00225,RC00676,RC00807,RC00808,RC01808,RC02226,RC02713 ko00000,ko00001,ko00002,ko01000 - - - Amino_oxidase k59_928889_1 1280944.HY17_04640 2.5e-39 146.0 COG0507@1|root,COG0507@2|Bacteria,1R1AT@1224|Proteobacteria,2U1ZX@28211|Alphaproteobacteria 28211|Alphaproteobacteria L A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD - - - - - - - - - - - - Terminase_6 k59_1664421_1 1177154.Y5S_01477 1.57e-38 140.0 COG2377@1|root,COG2377@2|Bacteria,1MV4E@1224|Proteobacteria,1RNTZ@1236|Gammaproteobacteria,1XH7D@135619|Oceanospirillales 135619|Oceanospirillales O Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling anmK - 2.7.1.170 ko:K09001 - - - - ko00000,ko01000 - - - AnmK k59_1664421_2 380358.XALC_0573 5.54e-31 123.0 COG0855@1|root,COG0855@2|Bacteria,1MUM3@1224|Proteobacteria,1RNRX@1236|Gammaproteobacteria,1X3E8@135614|Xanthomonadales 135614|Xanthomonadales P Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) ppk - 2.7.4.1 ko:K00937 ko00190,ko03018,map00190,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - PP_kinase,PP_kinase_C,PP_kinase_N k59_984594_1 1458427.BAWN01000006_gene394 2.58e-15 77.8 COG0583@1|root,COG0583@2|Bacteria,1MXR1@1224|Proteobacteria,2VHKB@28216|Betaproteobacteria,4ABGT@80864|Comamonadaceae 28216|Betaproteobacteria K Transcriptional regulator - - - ko:K19338 - - - - ko00000,ko03000 - - - HTH_1,LysR_substrate k59_1437114_1 566466.NOR53_3088 7.58e-60 192.0 COG0224@1|root,COG0224@2|Bacteria,1MU28@1224|Proteobacteria,1RNWJ@1236|Gammaproteobacteria,1J4Q3@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex atpG GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0036442,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045261,GO:0045262,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0046961,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - ko:K02115 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - iSSON_1240.SSON_3886,iYL1228.KPN_04138 ATP-synt k59_1437114_2 1027273.GZ77_21935 5.52e-07 50.1 COG0055@1|root,COG0055@2|Bacteria,1MUFU@1224|Proteobacteria,1RN6U@1236|Gammaproteobacteria,1XIMC@135619|Oceanospirillales 135619|Oceanospirillales C Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits atpD - 3.6.3.14 ko:K02112 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - - ATP-synt_ab,ATP-synt_ab_N k59_421241_2 1396141.BATP01000043_gene1940 9.01e-17 81.6 COG1529@1|root,COG1529@2|Bacteria,46U4N@74201|Verrucomicrobia,2IVIX@203494|Verrucomicrobiae 203494|Verrucomicrobiae C Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain - - - - - - - - - - - - Ald_Xan_dh_C2 k59_875572_1 1144305.PMI02_00848 3.72e-152 438.0 COG0006@1|root,COG0006@2|Bacteria,1Q1Z8@1224|Proteobacteria,2V63M@28211|Alphaproteobacteria,2KA9R@204457|Sphingomonadales 204457|Sphingomonadales E Metallopeptidase family M24 - - - - - - - - - - - - Peptidase_M24 k59_1497044_1 1144305.PMI02_05440 2.37e-59 189.0 COG1309@1|root,COG1309@2|Bacteria,1NMPS@1224|Proteobacteria,2UK21@28211|Alphaproteobacteria,2KAHI@204457|Sphingomonadales 204457|Sphingomonadales K PFAM Bacterial regulatory proteins, tetR family - - - - - - - - - - - - TetR_N k59_1497044_2 555793.WSK_0676 2.29e-14 71.6 COG1975@1|root,COG1975@2|Bacteria,1MXKU@1224|Proteobacteria,2TUF3@28211|Alphaproteobacteria,2K17D@204457|Sphingomonadales 204457|Sphingomonadales O Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family - - - ko:K07402 - - - - ko00000 - - - XdhC_C,XdhC_CoxI k59_705179_1 436308.Nmar_1731 3.11e-64 206.0 COG0075@1|root,arCOG00082@2157|Archaea,41SZZ@651137|Thaumarchaeota 651137|Thaumarchaeota E Aminotransferase class-V - - - - - - - - - - - - Aminotran_5 k59_532264_1 404589.Anae109_2417 8.98e-128 396.0 COG0308@1|root,COG0308@2|Bacteria,1MUCI@1224|Proteobacteria,42KZI@68525|delta/epsilon subdivisions,2WJ2C@28221|Deltaproteobacteria 28221|Deltaproteobacteria E Peptidase M1 membrane alanine aminopeptidase pepN - 3.4.11.2 ko:K01256,ko:K08776 ko00480,ko01100,map00480,map01100 - R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 - - - DUF3458,DUF3458_C,ERAP1_C,Peptidase_M1 k59_27733_2 1304872.JAGC01000009_gene57 3.3e-33 127.0 COG0341@1|root,COG0341@2|Bacteria,1MU74@1224|Proteobacteria,42M2H@68525|delta/epsilon subdivisions,2WJ8I@28221|Deltaproteobacteria,2M7R1@213115|Desulfovibrionales 28221|Deltaproteobacteria U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA secF - - ko:K03074 ko03060,ko03070,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 2.A.6.4,3.A.5.2,3.A.5.7 - - SecD_SecF,Sec_GG k59_646454_1 1502852.FG94_00977 2.42e-37 129.0 COG1393@1|root,COG1393@2|Bacteria,1MZ6S@1224|Proteobacteria,2VUB7@28216|Betaproteobacteria,474H0@75682|Oxalobacteraceae 28216|Betaproteobacteria P Belongs to the ArsC family yffB - 1.20.4.1 ko:K00537 - - - - ko00000,ko01000 - - - ArsC k59_646454_2 1123401.JHYQ01000022_gene1089 3.37e-26 102.0 COG2171@1|root,COG2171@2|Bacteria,1MU0Y@1224|Proteobacteria,1RPCS@1236|Gammaproteobacteria,45ZN7@72273|Thiotrichales 72273|Thiotrichales E Belongs to the transferase hexapeptide repeat family dapD - 2.3.1.117 ko:K00674 ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230 M00016 R04365 RC00004,RC01136 ko00000,ko00001,ko00002,ko01000 - - - Hexapep,Hexapep_2,THDPS_N_2 k59_1045332_1 314278.NB231_15498 6.8e-25 103.0 COG0104@1|root,COG0104@2|Bacteria,1MU5B@1224|Proteobacteria,1RNEW@1236|Gammaproteobacteria,1WW9J@135613|Chromatiales 135613|Chromatiales F Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP purA - 6.3.4.4 ko:K01939 ko00230,ko00250,ko01100,map00230,map00250,map01100 M00049 R01135 RC00458,RC00459 ko00000,ko00001,ko00002,ko01000 - - - Adenylsucc_synt k59_310390_1 290398.Csal_2642 1.18e-32 123.0 COG0494@1|root,COG0494@2|Bacteria,1RD2C@1224|Proteobacteria,1S8G8@1236|Gammaproteobacteria,1XKAX@135619|Oceanospirillales 135619|Oceanospirillales L COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes - - - - - - - - - - - - NUDIX k59_532274_1 713586.KB900536_gene3028 0.000167 43.5 COG0061@1|root,COG0061@2|Bacteria,1MUBC@1224|Proteobacteria,1RP84@1236|Gammaproteobacteria,1WXJR@135613|Chromatiales 135613|Chromatiales G Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP nadK - 2.7.1.23 ko:K00858 ko00760,ko01100,map00760,map01100 - R00104 RC00002,RC00078 ko00000,ko00001,ko01000 - - - NAD_kinase k59_532274_2 391615.ABSJ01000026_gene100 2.22e-58 197.0 COG0497@1|root,COG0497@2|Bacteria,1MUNP@1224|Proteobacteria,1RNPZ@1236|Gammaproteobacteria,1J5DR@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L May be involved in recombinational repair of damaged DNA recN GO:0000724,GO:0000725,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009314,GO:0009432,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0090304,GO:1901360 - ko:K03631 - - - - ko00000,ko03400 - - - AAA_23,SMC_N k59_1324693_1 436308.Nmar_1708 3.26e-51 165.0 COG0071@1|root,arCOG01832@2157|Archaea,41T74@651137|Thaumarchaeota 651137|Thaumarchaeota O Belongs to the small heat shock protein (HSP20) family - - - - - - - - - - - - HSP20 k59_476838_1 279714.FuraDRAFT_0829 4.92e-20 94.0 COG4965@1|root,COG4965@2|Bacteria,1MUXK@1224|Proteobacteria,2VJ80@28216|Betaproteobacteria 28216|Betaproteobacteria U Type II secretion system - - - ko:K12510 - - - - ko00000,ko02044 - - - T2SSF k59_1155877_1 272844.PAB1638 8.6e-40 145.0 COG0404@1|root,arCOG00756@2157|Archaea,2XU1F@28890|Euryarchaeota,242X7@183968|Thermococci 183968|Thermococci E The glycine cleavage system catalyzes the degradation of glycine gcvT - 2.1.2.10 ko:K00605 ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200 M00532 R01221,R02300,R04125 RC00022,RC00069,RC00183,RC02834 ko00000,ko00001,ko00002,ko01000 - - - GCV_T,GCV_T_C k59_1155877_2 330214.NIDE0319 1.82e-12 64.3 COG0494@1|root,COG0494@2|Bacteria,3J0TN@40117|Nitrospirae 40117|Nitrospirae L NUDIX domain - - 3.6.1.13 ko:K01515 ko00230,map00230 - R01054 RC00002 ko00000,ko00001,ko01000 - - - NUDIX k59_1213554_1 215803.DB30_6014 2.72e-125 392.0 COG1200@1|root,COG1200@2|Bacteria,1MWN2@1224|Proteobacteria,42NF8@68525|delta/epsilon subdivisions,2WKBA@28221|Deltaproteobacteria,2YXV4@29|Myxococcales 28221|Deltaproteobacteria L Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA) recG - 3.6.4.12 ko:K03655 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,Helicase_C,RecG_wedge k59_476840_1 1121931.AUHG01000012_gene2925 1.11e-12 67.4 COG1917@1|root,COG1917@2|Bacteria,4P2XE@976|Bacteroidetes,1IAY3@117743|Flavobacteriia 976|Bacteroidetes S Cupin 2, conserved barrel domain protein - - - - - - - - - - - - - k59_1609495_1 158500.BV97_03201 5.33e-109 333.0 COG2072@1|root,COG2072@2|Bacteria,1NSY9@1224|Proteobacteria,2UQPS@28211|Alphaproteobacteria,2K129@204457|Sphingomonadales 204457|Sphingomonadales P Flavin-binding monooxygenase-like - - - - - - - - - - - - FMO-like,NAD_binding_8,Pyr_redox_2,Pyr_redox_3 k59_1445081_1 1123242.JH636434_gene3809 6.01e-51 167.0 COG0698@1|root,COG0698@2|Bacteria,2IZSB@203682|Planctomycetes 203682|Planctomycetes G Ribose/Galactose Isomerase - - 5.3.1.6 ko:K01808 ko00030,ko00051,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00051,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01056,R09030 RC00376,RC00434 ko00000,ko00001,ko00002,ko01000 - - - LacAB_rpiB k59_1106545_1 472759.Nhal_1415 2e-23 101.0 COG2204@1|root,COG2207@1|root,COG2204@2|Bacteria,COG2207@2|Bacteria,1N1CY@1224|Proteobacteria,1SBMK@1236|Gammaproteobacteria 1236|Gammaproteobacteria K regulator - - - - - - - - - - - - HTH_18,HTH_AraC,PocR,Response_reg,Sigma54_activ_2 k59_654441_1 383381.EH30_00770 1.19e-83 259.0 COG3509@1|root,COG3509@2|Bacteria,1QYYG@1224|Proteobacteria,2U47F@28211|Alphaproteobacteria,2K5HN@204457|Sphingomonadales 204457|Sphingomonadales Q depolymerase - - - - - - - - - - - - - k59_1275082_1 644801.Psest_2417 4.33e-87 280.0 COG1629@1|root,COG4771@2|Bacteria,1MUWN@1224|Proteobacteria,1RN1E@1236|Gammaproteobacteria,1Z1A3@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria P COG1629 Outer membrane receptor proteins, mostly Fe transport - - - - - - - - - - - - CarbopepD_reg_2,CarboxypepD_reg,Plug,TonB_dep_Rec k59_602612_1 454957.IA64_08955 7.81e-17 86.3 COG0642@1|root,COG0784@1|root,COG2202@1|root,COG2203@1|root,COG0784@2|Bacteria,COG2202@2|Bacteria,COG2203@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,1RQ3H@1236|Gammaproteobacteria,1X3SI@135614|Xanthomonadales 135614|Xanthomonadales T two-component system sensor protein - - - - - - - - - - - - GAF,GAF_2,HATPase_c,HisKA,PAS_3,PAS_4,Response_reg k59_886002_2 640512.BC1003_1659 9.54e-89 280.0 COG0668@1|root,COG0668@2|Bacteria,1MW7V@1224|Proteobacteria,2VHE7@28216|Betaproteobacteria,1K4DA@119060|Burkholderiaceae 28216|Betaproteobacteria M Mechanosensitive ion channel - - - - - - - - - - - - MS_channel k59_1054085_1 1122603.ATVI01000005_gene3276 2.68e-55 188.0 COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,1RR00@1236|Gammaproteobacteria,1X4PX@135614|Xanthomonadales 135614|Xanthomonadales EH Belongs to the TPP enzyme family - - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_937726_2 1242864.D187_006287 8.41e-53 186.0 COG0195@1|root,COG0195@2|Bacteria,1MWT7@1224|Proteobacteria,42MUW@68525|delta/epsilon subdivisions,2WIXI@28221|Deltaproteobacteria,2YUJG@29|Myxococcales 28221|Deltaproteobacteria K Participates in both transcription termination and antitermination nusA - - ko:K02600 - - - - ko00000,ko03009,ko03021 - - - HHH_5,KH_5,NusA_N,S1 k59_1618349_1 1096930.L284_13205 2.35e-09 55.1 COG0776@1|root,COG0776@2|Bacteria,1RH5Z@1224|Proteobacteria,2UCDG@28211|Alphaproteobacteria,2K62D@204457|Sphingomonadales 204457|Sphingomonadales K This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control himA - - ko:K04764 - - - - ko00000,ko03032,ko03036,ko03400 - - - Bac_DNA_binding k59_1618349_2 1112212.JH584235_gene2589 1.01e-53 177.0 COG0332@1|root,COG0332@2|Bacteria,1MU9N@1224|Proteobacteria,2TR60@28211|Alphaproteobacteria,2K1XQ@204457|Sphingomonadales 204457|Sphingomonadales I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids fabH - 2.3.1.180 ko:K00648 ko00061,ko01100,ko01212,map00061,map01100,map01212 M00082,M00083 R10707 RC00004,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - ACP_syn_III,ACP_syn_III_C k59_655325_1 1038862.KB893854_gene50 2.78e-25 108.0 COG0477@1|root,COG2814@2|Bacteria,1MW59@1224|Proteobacteria,2TRA3@28211|Alphaproteobacteria,3JX2U@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria EGP Major Facilitator Superfamily - - - - - - - - - - - - MFS_1,Sugar_tr k59_321962_1 41875.XP_007508975.1 2.84e-39 150.0 COG0141@1|root,KOG2697@2759|Eukaryota,37Q6A@33090|Viridiplantae,34JY6@3041|Chlorophyta 3041|Chlorophyta E Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine - - 1.1.1.23 ko:K00013 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R01158,R01163,R03012 RC00099,RC00242,RC00463 ko00000,ko00001,ko00002,ko01000 - - - Histidinol_dh k59_1332877_1 1229909.NSED_09170 1.05e-81 249.0 COG0500@1|root,arCOG04347@2157|Archaea,41T35@651137|Thaumarchaeota 651137|Thaumarchaeota Q Nodulation protein S (NodS) - - - - - - - - - - - - - k59_1782866_1 396588.Tgr7_2406 1.87e-79 256.0 COG0739@1|root,COG0739@2|Bacteria,1MVTF@1224|Proteobacteria,1RM7S@1236|Gammaproteobacteria,1WX4H@135613|Chromatiales 135613|Chromatiales M PFAM peptidase - - - - - - - - - - - - OapA,Peptidase_M23 k59_1054944_1 1122137.AQXF01000002_gene409 1.32e-98 314.0 COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TQQ9@28211|Alphaproteobacteria 28211|Alphaproteobacteria T Histidine kinase cckA - 2.7.13.3 ko:K13587 ko02020,ko04112,map02020,map04112 M00512 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA,PAS,PAS_4,PAS_8,PAS_9,Response_reg k59_1782885_1 314287.GB2207_11688 1.72e-69 220.0 COG1181@1|root,COG1181@2|Bacteria,1MUTB@1224|Proteobacteria,1RMTM@1236|Gammaproteobacteria,1J4MW@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria F Belongs to the D-alanine--D-alanine ligase family ddl - 6.3.2.4 ko:K01921 ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502 - R01150 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Dala_Dala_lig_C,Dala_Dala_lig_N k59_206263_1 1085623.GNIT_3278 7.34e-67 220.0 COG1301@1|root,COG1301@2|Bacteria,1MU0Q@1224|Proteobacteria,1RMEN@1236|Gammaproteobacteria,463Y3@72275|Alteromonadaceae 1236|Gammaproteobacteria U Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family - - - - - - - - - - - - SDF k59_378308_1 1049564.TevJSym_aq00710 4.94e-76 241.0 COG4656@1|root,COG4656@2|Bacteria,1QTUI@1224|Proteobacteria,1RMIM@1236|Gammaproteobacteria,1J4YP@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Part of a membrane complex involved in electron transport - - - ko:K03615 - - - - ko00000 - - - Complex1_51K,Fer4_10,Fer4_17,RnfC_N,SLBB k59_1222881_1 1415780.JPOG01000001_gene2680 1.38e-65 213.0 COG4964@1|root,COG4964@2|Bacteria,1MV8G@1224|Proteobacteria,1RQ4U@1236|Gammaproteobacteria,1X59M@135614|Xanthomonadales 135614|Xanthomonadales U Belongs to the GSP D family - - - ko:K02280 - - - - ko00000,ko02035,ko02044 - - - Secretin,T2SS-T3SS_pil_N k59_206267_1 443144.GM21_3233 1.32e-14 73.6 COG0826@1|root,COG0826@2|Bacteria,1QMCE@1224|Proteobacteria,42PSK@68525|delta/epsilon subdivisions,2WKMU@28221|Deltaproteobacteria 28221|Deltaproteobacteria O peptidase U32 - - - - - - - - - - - - Peptidase_U32 k59_206267_2 876269.ARWA01000001_gene1704 4.96e-09 59.3 COG3424@1|root,COG3424@2|Bacteria,1MUDX@1224|Proteobacteria,2TRTX@28211|Alphaproteobacteria,3NBHS@45404|Beijerinckiaceae 28211|Alphaproteobacteria Q Chalcone and stilbene synthases, C-terminal domain - - - ko:K16167 - - - - ko00000,ko01008 - - - Chal_sti_synt_C,Chal_sti_synt_N k59_1395018_1 1122609.AUGT01000009_gene3252 1.48e-34 122.0 COG0789@1|root,COG0789@2|Bacteria,2GKTU@201174|Actinobacteria,4DQMW@85009|Propionibacteriales 201174|Actinobacteria K redox-sensitive transcriptional activator SoxR soxR - - ko:K13639 - - - - ko00000,ko03000 - - - MerR,MerR-DNA-bind,MerR_1 k59_1395018_2 28042.GU90_09915 8.03e-75 231.0 COG3959@1|root,COG3959@2|Bacteria,2GNWW@201174|Actinobacteria,4DZ7W@85010|Pseudonocardiales 201174|Actinobacteria G Transketolase, thiamine diphosphate binding domain fas2 - 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 - - - Transketolase_N k59_767505_1 1121935.AQXX01000113_gene1435 1.54e-19 88.2 COG1752@1|root,COG1752@2|Bacteria,1MUM9@1224|Proteobacteria,1RRA1@1236|Gammaproteobacteria,1XHWW@135619|Oceanospirillales 1236|Gammaproteobacteria S esterase of the alpha-beta hydrolase superfamily - - - ko:K07001 - - - - ko00000 - - - Patatin k59_1618392_1 383372.Rcas_3812 9.61e-32 119.0 COG0462@1|root,COG0462@2|Bacteria,2G5T8@200795|Chloroflexi,376D2@32061|Chloroflexia 32061|Chloroflexia F Phosphoribosyl synthetase-associated domain - - 2.7.6.1 ko:K00948 ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230 M00005 R01049 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - Pribosyl_synth,Pribosyltran_N k59_1618392_2 1279017.AQYJ01000024_gene853 2.05e-13 70.9 COG3213@1|root,COG3213@2|Bacteria,1MUJK@1224|Proteobacteria,1RMCR@1236|Gammaproteobacteria,466R8@72275|Alteromonadaceae 1236|Gammaproteobacteria P protein involved in response to NO nnrS - - ko:K07234 - - - - ko00000 - - - NnrS k59_1446240_1 247634.GPB2148_173 4.06e-101 301.0 COG3828@1|root,COG3828@2|Bacteria,1RF65@1224|Proteobacteria,1SZ1Y@1236|Gammaproteobacteria,1J9R5@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Trehalose utilisation - - - - - - - - - - - - ThuA k59_826518_1 1088721.NSU_1242 9.74e-73 237.0 COG1716@1|root,COG1716@2|Bacteria,1R72N@1224|Proteobacteria,2U42V@28211|Alphaproteobacteria,2K0ZA@204457|Sphingomonadales 204457|Sphingomonadales C Cytochrome c3 - - - - - - - - - - - - Cytochrom_c3_2 k59_655359_1 317025.Tcr_1331 5.02e-47 169.0 COG0342@1|root,COG0342@2|Bacteria,1MV5U@1224|Proteobacteria,1RMIQ@1236|Gammaproteobacteria,45ZN8@72273|Thiotrichales 72273|Thiotrichales U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA secD - - ko:K03072 ko03060,ko03070,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 2.A.6.4,3.A.5.2,3.A.5.7 - - SecD-TM1,SecD_SecF,Sec_GG k59_937796_1 1415778.JQMM01000001_gene1715 1.8e-25 102.0 COG1381@1|root,COG1381@2|Bacteria,1RHIC@1224|Proteobacteria,1RN8Y@1236|Gammaproteobacteria,1J6DG@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L Involved in DNA repair and RecF pathway recombination recO GO:0008150,GO:0009314,GO:0009628,GO:0050896 - ko:K03584 ko03440,map03440 - - - ko00000,ko00001,ko03400 - - - RecO_C,RecO_N k59_937796_2 926561.KB900617_gene1763 1.28e-17 81.6 COG1159@1|root,COG1159@2|Bacteria,1TP3R@1239|Firmicutes,24876@186801|Clostridia,3WA70@53433|Halanaerobiales 186801|Clostridia S An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism era - - ko:K03595 - - - - ko00000,ko03009,ko03029 - - - KH_2,MMR_HSR1 k59_1782906_1 313596.RB2501_12202 1.63e-22 95.9 2E3AK@1|root,320TI@2|Bacteria,4NRX2@976|Bacteroidetes,1I3SJ@117743|Flavobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_1054974_1 1117943.SFHH103_02164 3.03e-68 217.0 COG0462@1|root,COG0462@2|Bacteria,1MW21@1224|Proteobacteria,2TR4Y@28211|Alphaproteobacteria,4B7Z7@82115|Rhizobiaceae 28211|Alphaproteobacteria F Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P) prs - 2.7.6.1 ko:K00948 ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230 M00005 R01049 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - Pribosyl_synth,Pribosyltran,Pribosyltran_N k59_1565464_1 1121405.dsmv_3659 3.11e-55 192.0 COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,42NCZ@68525|delta/epsilon subdivisions,2WK3X@28221|Deltaproteobacteria,2MI5E@213118|Desulfobacterales 28221|Deltaproteobacteria P Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K07787 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.6.1.4 - iAF987.Gmet_1547 ACR_tran k59_38809_2 1357279.N018_17845 5.44e-26 108.0 COG4104@1|root,COG4104@2|Bacteria,1RIIQ@1224|Proteobacteria,1S6PW@1236|Gammaproteobacteria,1Z71Y@136849|Pseudomonas syringae group 1236|Gammaproteobacteria S Bacterial toxin 44 - - - - - - - - - - - - Ntox44,PAAR_motif k59_485192_1 926569.ANT_08580 5.44e-37 144.0 COG2199@1|root,COG2203@1|root,COG3850@1|root,COG2203@2|Bacteria,COG3706@2|Bacteria,COG3850@2|Bacteria,2G87Y@200795|Chloroflexi 200795|Chloroflexi T PFAM GGDEF domain containing protein - - - - - - - - - - - - GAF,GAF_2,GGDEF,HisKA_7TM,PAS_4,PAS_8 k59_94450_1 1122197.ATWI01000013_gene2331 2.24e-63 215.0 COG0119@1|root,COG0119@2|Bacteria,1MVQG@1224|Proteobacteria,1RPPW@1236|Gammaproteobacteria 1236|Gammaproteobacteria E Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of aromatic compounds - - 4.1.3.39 ko:K01666 ko00360,ko00362,ko00621,ko00622,ko01100,ko01120,ko01220,map00360,map00362,map00621,map00622,map01100,map01120,map01220 M00545,M00569 R00750 RC00307,RC00371 br01602,ko00000,ko00001,ko00002,ko01000 - - - HMGL-like k59_655364_1 1122137.AQXF01000001_gene2791 7.2e-190 533.0 COG0196@1|root,COG0196@2|Bacteria,1MV9I@1224|Proteobacteria,2TTUY@28211|Alphaproteobacteria 28211|Alphaproteobacteria H Belongs to the ribF family ribF - 2.7.1.26,2.7.7.2 ko:K11753 ko00740,ko01100,ko01110,map00740,map01100,map01110 M00125 R00161,R00549 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - FAD_syn,Flavokinase k59_1672786_1 543632.JOJL01000001_gene7756 8.07e-06 58.2 COG3629@1|root,COG3899@1|root,COG3629@2|Bacteria,COG3899@2|Bacteria,2I2U4@201174|Actinobacteria 201174|Actinobacteria K Transcriptional regulator - - - - - - - - - - - - AAA_16,BTAD,GerE,Trans_reg_C k59_206319_1 330214.NIDE0758 6.18e-98 294.0 COG0472@1|root,COG0472@2|Bacteria,3J0C4@40117|Nitrospirae 40117|Nitrospirae M First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan mraY - 2.7.8.13 ko:K01000 ko00550,ko01100,ko01502,map00550,map01100,map01502 - R05629,R05630 RC00002,RC02753 ko00000,ko00001,ko01000,ko01011 9.B.146 - - Glycos_transf_4,MraY_sig1 k59_655372_1 266834.SM_b21167 1.17e-66 218.0 COG3344@1|root,COG3344@2|Bacteria,1MVI1@1224|Proteobacteria,2U1Z0@28211|Alphaproteobacteria,4BBMN@82115|Rhizobiaceae 28211|Alphaproteobacteria L reverse transcriptase - - - ko:K15342 - - - - ko00000,ko02048,ko03400 - - - Cas_Cas1,GIIM,RVT_1 k59_1446285_1 1210884.HG799463_gene9944 7.43e-06 53.9 COG4191@1|root,COG4251@1|root,COG4191@2|Bacteria,COG4251@2|Bacteria,2IWUM@203682|Planctomycetes 203682|Planctomycetes T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - HATPase_c,HisKA,PAS,PAS_3,PAS_4,Response_reg k59_1565494_1 1122137.AQXF01000004_gene1798 1.23e-64 221.0 COG2911@1|root,COG2931@1|root,COG2911@2|Bacteria,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,2TRVY@28211|Alphaproteobacteria 28211|Alphaproteobacteria Q COG2931 RTX toxins and related Ca2 -binding proteins - - - ko:K07004 - - - - ko00000 - - - Calx-beta,DUF4347,HemolysinCabind,P_proprotein,Peptidase_M10,Peptidase_M10_C,Peptidase_S8 k59_263482_1 485918.Cpin_1280 2.4e-34 132.0 COG1044@1|root,COG1044@2|Bacteria,4NE5G@976|Bacteroidetes,1IP38@117747|Sphingobacteriia 976|Bacteroidetes M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell lpxD - 2.3.1.191 ko:K02536 ko00540,ko01100,map00540,map01100 M00060 R04550 RC00039,RC00166 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Hexapep,Hexapep_2,LpxD k59_206330_1 1110502.TMO_3297 5.45e-75 236.0 COG1028@1|root,COG1028@2|Bacteria,1PEWK@1224|Proteobacteria,2TV4E@28211|Alphaproteobacteria,2JWBD@204441|Rhodospirillales 204441|Rhodospirillales IQ KR domain - - - - - - - - - - - - adh_short_C2 k59_322041_1 1095769.CAHF01000022_gene292 4.77e-67 223.0 COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,2VISZ@28216|Betaproteobacteria,4736U@75682|Oxalobacteraceae 28216|Betaproteobacteria MU Outer membrane efflux protein nodT - - - - - - - - - - - OEP k59_1446300_1 876044.IMCC3088_194 4.27e-99 296.0 COG1638@1|root,COG1638@2|Bacteria,1MVHC@1224|Proteobacteria,1RPNJ@1236|Gammaproteobacteria,1J67A@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria G C4-dicarboxylate ABC transporter - - - - - - - - - - - - DctP k59_1055025_1 331869.BAL199_26227 3.82e-123 363.0 COG0683@1|root,COG0683@2|Bacteria,1MVZR@1224|Proteobacteria,2TRRP@28211|Alphaproteobacteria,4BRXD@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria E COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component - - - ko:K01999 ko02010,ko02024,map02010,map02024 M00237 - - ko00000,ko00001,ko00002,ko02000 3.A.1.4 - - Peripla_BP_6 k59_429631_1 298654.FraEuI1c_4405 8.5e-21 96.7 COG0823@1|root,COG0823@2|Bacteria 2|Bacteria U Involved in the tonB-independent uptake of proteins - - - - - - - - - - - - HYR,PD40,REJ,RicinB_lectin_2 k59_886811_2 314287.GB2207_04502 1.4e-24 103.0 COG3073@1|root,COG3073@2|Bacteria,1N9FN@1224|Proteobacteria,1SWYJ@1236|Gammaproteobacteria,1J6IG@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T Anti sigma-E protein RseA, N-terminal domain - - - ko:K03597 - - - - ko00000,ko03021 - - - RseA_N k59_148736_1 1042375.AFPL01000026_gene3727 1.27e-109 330.0 COG2224@1|root,COG2224@2|Bacteria,1MWIF@1224|Proteobacteria,1RQAK@1236|Gammaproteobacteria,4659E@72275|Alteromonadaceae 1236|Gammaproteobacteria C Isocitrate lyase aceA - 4.1.3.1 ko:K01637 ko00630,ko01100,ko01110,ko01120,ko01200,map00630,map01100,map01110,map01120,map01200 M00012 R00479 RC00311,RC00313 ko00000,ko00001,ko00002,ko01000 - - - ICL k59_1166803_1 1316932.MHH_c12390 1.01e-05 53.1 COG0471@1|root,COG0490@1|root,COG0471@2|Bacteria,COG0490@2|Bacteria,1MU0K@1224|Proteobacteria,1RMI1@1236|Gammaproteobacteria,1Y7E8@135625|Pasteurellales 135625|Pasteurellales P Di- and tricarboxylate transporters - - - - - - - - - - - - CitMHS,Na_sulph_symp,TrkA_C k59_1508028_1 1268240.ATFI01000005_gene4570 5.25e-15 80.1 COG2207@1|root,COG3292@1|root,COG4191@1|root,COG2207@2|Bacteria,COG3292@2|Bacteria,COG4191@2|Bacteria,4NJY5@976|Bacteroidetes,2FPYM@200643|Bacteroidia,4AQ0G@815|Bacteroidaceae 976|Bacteroidetes T Two component regulator propeller - - - - - - - - - - - - HTH_18,Reg_prop,Y_Y_Y k59_1672808_2 1349767.GJA_1526 7.12e-51 189.0 COG1524@1|root,COG1524@2|Bacteria,1R5V5@1224|Proteobacteria,2WBX4@28216|Betaproteobacteria,476MV@75682|Oxalobacteraceae 28216|Betaproteobacteria S Type I phosphodiesterase / nucleotide pyrophosphatase - - - - - - - - - - - - Phosphodiest k59_1276006_1 981384.AEYW01000005_gene3057 1.54e-45 152.0 COG0799@1|root,COG0799@2|Bacteria,1MZEF@1224|Proteobacteria,2UBSV@28211|Alphaproteobacteria,4NC9Z@97050|Ruegeria 28211|Alphaproteobacteria J Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation rsfS - - ko:K09710 - - - - ko00000,ko03009 - - - RsfS k59_993141_1 926569.ANT_11200 7.73e-60 202.0 COG2843@1|root,COG2843@2|Bacteria,2G78I@200795|Chloroflexi 200795|Chloroflexi M Bacterial capsule synthesis protein PGA_cap - - - ko:K07282 - - - - ko00000 - - - PGA_cap k59_1107526_1 656024.FsymDg_0509 1.48e-102 307.0 COG2301@1|root,COG2301@2|Bacteria,2GK5J@201174|Actinobacteria,4ESAE@85013|Frankiales 201174|Actinobacteria G Belongs to the HpcH HpaI aldolase family - - 4.1.3.24,4.1.3.25 ko:K08691 ko00630,ko00660,ko00680,ko00720,ko01120,ko01200,map00630,map00660,map00680,map00720,map01120,map01200 M00346,M00373,M00376 R00237,R00473,R00934 RC00307,RC00308,RC00311,RC00407,RC00502,RC01205 ko00000,ko00001,ko00002,ko01000 - - - HpcH_HpaI k59_1222991_1 1173024.KI912149_gene5615 5.27e-19 89.7 COG1835@1|root,COG1835@2|Bacteria,1GGW4@1117|Cyanobacteria 1117|Cyanobacteria I Acyltransferase family - - - - - - - - - - - - Acyl_transf_3 k59_826579_2 1197477.IA57_12670 1.41e-112 325.0 COG4445@1|root,COG4445@2|Bacteria,4NFY4@976|Bacteroidetes,1HYKM@117743|Flavobacteriia 976|Bacteroidetes FJ Hydroxylase for synthesis of 2-methylthio-cis-ribozeatin in tRNA miaE - - ko:K06169 - - - - ko00000,ko01000,ko03016 - - - MiaE k59_1782967_1 1209072.ALBT01000032_gene1996 1.03e-217 608.0 COG0505@1|root,COG0505@2|Bacteria,1MUB9@1224|Proteobacteria,1RMAW@1236|Gammaproteobacteria,1FG2U@10|Cellvibrio 1236|Gammaproteobacteria F Carbamoyl-phosphate synthase small chain, CPSase domain carA GO:0000050,GO:0003674,GO:0003824,GO:0004088,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005951,GO:0006082,GO:0006139,GO:0006206,GO:0006207,GO:0006220,GO:0006221,GO:0006520,GO:0006525,GO:0006526,GO:0006541,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019627,GO:0019637,GO:0019693,GO:0019752,GO:0019856,GO:0032991,GO:0034641,GO:0034654,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046112,GO:0046390,GO:0046394,GO:0046483,GO:0055086,GO:0071704,GO:0071941,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494 6.3.5.5 ko:K01956 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - iAPECO1_1312.APECO1_1950,iUTI89_1310.UTI89_C0036,ic_1306.c0040 CPSase_sm_chain,GATase k59_378401_1 257310.BB3219 5.72e-84 260.0 COG0160@1|root,COG0160@2|Bacteria,1MWY6@1224|Proteobacteria,2VI11@28216|Betaproteobacteria,3T2Y8@506|Alcaligenaceae 28216|Betaproteobacteria H Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family ectB - 2.6.1.76 ko:K00836 ko00260,ko01100,ko01120,ko01210,ko01230,map00260,map01100,map01120,map01210,map01230 M00033 R06977 RC00006,RC00062 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 k59_1107540_1 1000565.METUNv1_00295 2.08e-18 84.3 COG2230@1|root,COG2230@2|Bacteria,1MX3U@1224|Proteobacteria,2VJ00@28216|Betaproteobacteria,2KVAC@206389|Rhodocyclales 206389|Rhodocyclales M Cyclopropane fatty acid synthase cfaA - 2.1.1.79 ko:K00574 - - - - ko00000,ko01000 - - - CMAS k59_767579_1 1166948.JPZL01000003_gene862 1.1e-87 272.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,1XI3Y@135619|Oceanospirillales 135619|Oceanospirillales T Response regulator of a two-component regulatory system involved in the activation of nitrogen assimilation genes glnG - - ko:K07712 ko02020,map02020 M00497 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_603602_2 1173027.Mic7113_0312 1.04e-10 63.5 COG0703@1|root,COG0703@2|Bacteria 2|Bacteria F shikimate kinase activity cas2 - 2.7.1.71 ko:K00891 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02412 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - 6PF2K,AAA_33,His_Phos_1,SKI k59_1782978_1 76114.ebA4051 7.47e-72 231.0 COG1139@1|root,COG1139@2|Bacteria,1MV6J@1224|Proteobacteria,2VJ3Y@28216|Betaproteobacteria,2KU8D@206389|Rhodocyclales 206389|Rhodocyclales C Domain of unknown function (DUF3390) - - - ko:K18929 - - - - ko00000 - - - DUF3390,Fer4_8,LUD_dom k59_836024_1 7213.XP_004533140.1 2.33e-30 124.0 COG0445@1|root,KOG2311@2759|Eukaryota,38BWB@33154|Opisthokonta,3BFG6@33208|Metazoa,3CTUH@33213|Bilateria,41TFM@6656|Arthropoda,3SKGZ@50557|Insecta,4520R@7147|Diptera 33208|Metazoa J Flavin adenine dinucleotide binding. It is involved in the biological process described with tRNA wobble uridine modification - - - - - - - - - - - - GIDA,GIDA_assoc,GidB k59_158153_1 44689.DDB0214905 4.74e-115 337.0 COG1351@1|root,2SRAF@2759|Eukaryota,3XEH7@554915|Amoebozoa 554915|Amoebozoa H Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant - GO:0003674,GO:0003824,GO:0006139,GO:0006220,GO:0006221,GO:0006231,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009157,GO:0009162,GO:0009165,GO:0009176,GO:0009177,GO:0009219,GO:0009221,GO:0009262,GO:0009263,GO:0009265,GO:0009394,GO:0009987,GO:0016740,GO:0016741,GO:0018130,GO:0019438,GO:0019637,GO:0019692,GO:0032259,GO:0034641,GO:0034654,GO:0042083,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046073,GO:0046385,GO:0046483,GO:0050797,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.1.1.148 ko:K03465 ko00240,ko00670,ko01100,map00240,map00670,map01100 - R06613 RC00022,RC00332 ko00000,ko00001,ko01000 - - - Thy1 k59_273430_1 316407.85677061 1.85e-111 321.0 COG3539@1|root,COG3539@2|Bacteria,1R6J8@1224|Proteobacteria,1S138@1236|Gammaproteobacteria,3XN73@561|Escherichia 1236|Gammaproteobacteria NU Involved in regulation of length and mediation of adhesion of type 1 fimbriae (but not necessary for the production of fimbriae). Involved in the integration of FimH in the fimbriae fimF GO:0005575,GO:0005623,GO:0009289,GO:0042995,GO:0044464 - ko:K07348 - - - - ko00000,ko02035,ko02044 - - - Fimbrial k59_665366_2 1100720.ALKN01000033_gene845 1.91e-11 65.9 COG1208@1|root,COG1208@2|Bacteria,1R9ZD@1224|Proteobacteria,2VJUN@28216|Betaproteobacteria,4AAH6@80864|Comamonadaceae 28216|Betaproteobacteria JM Nucleotidyl transferase rmlA - 2.7.7.99 ko:K00992 ko00520,ko01100,map00520,map01100 - R11025 RC00002 ko00000,ko00001,ko01000 - - - NTP_transferase k59_1286175_1 485913.Krac_2427 2.03e-88 271.0 COG0673@1|root,COG0673@2|Bacteria,2G851@200795|Chloroflexi 200795|Chloroflexi S PFAM oxidoreductase domain protein - - - - - - - - - - - - GFO_IDH_MocA k59_726383_1 1042377.AFPJ01000015_gene1619 2.38e-151 432.0 COG0179@1|root,COG0179@2|Bacteria,1MV0V@1224|Proteobacteria,1RNYV@1236|Gammaproteobacteria,465V2@72275|Alteromonadaceae 1236|Gammaproteobacteria Q COG0179 2-keto-4-pentenoate hydratase 2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) uptA - 3.7.1.2 ko:K16171 ko00350,ko00643,ko01100,ko01120,map00350,map00643,map01100,map01120 M00044 R01364 RC00326,RC00446 ko00000,ko00001,ko00002,ko01000 - - - FAA_hydrolase k59_1627654_1 1242864.D187_009316 1.66e-24 104.0 COG1228@1|root,COG1228@2|Bacteria,1MY4V@1224|Proteobacteria,4383R@68525|delta/epsilon subdivisions,2X3DQ@28221|Deltaproteobacteria,2YVM1@29|Myxococcales 28221|Deltaproteobacteria Q Amidohydrolase family - - - - - - - - - - - - Amidohydro_1 k59_1517493_1 1209072.ALBT01000035_gene1447 9.07e-120 356.0 COG0147@1|root,COG0147@2|Bacteria,1MVBJ@1224|Proteobacteria,1RMSE@1236|Gammaproteobacteria,1FGZ9@10|Cellvibrio 1236|Gammaproteobacteria EH Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia trpE - 4.1.3.27 ko:K01657 ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025 M00023 R00985,R00986 RC00010,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 - - iJN746.PP_0417 Anth_synt_I_N,Chorismate_bind k59_1117130_1 1123037.AUDE01000011_gene889 3.43e-31 119.0 COG0392@1|root,COG0392@2|Bacteria,4NI8Y@976|Bacteroidetes,1HZ5W@117743|Flavobacteriia 976|Bacteroidetes S PFAM Uncharacterised protein family (UPF0104) - - - ko:K07027 - - - - ko00000,ko02000 4.D.2 - - LPG_synthase_TM k59_1117130_2 1392490.JHZX01000001_gene2149 7.95e-34 123.0 COG2885@1|root,COG2885@2|Bacteria,4NMF0@976|Bacteroidetes,1IJWQ@117743|Flavobacteriia 976|Bacteroidetes M chlorophyll binding - - - - - - - - - - - - OMP_b-brl k59_47830_1 1229909.NSED_09210 5.8e-102 300.0 COG1047@1|root,arCOG00980@2157|Archaea,41T0T@651137|Thaumarchaeota 651137|Thaumarchaeota O Peptidyl-prolyl cis-trans - - 5.2.1.8 ko:K01802 - - - - ko00000,ko01000 - - - FKBP_C k59_1792429_1 1379281.AVAG01000104_gene1712 3.06e-08 60.8 COG3464@1|root,COG3464@2|Bacteria,1MV5J@1224|Proteobacteria,42YAP@68525|delta/epsilon subdivisions,2WUHG@28221|Deltaproteobacteria,2MGCZ@213115|Desulfovibrionales 28221|Deltaproteobacteria L Helix-turn-helix domain of transposase family ISL3 - - - - - - - - - - - - DDE_Tnp_ISL3,HTH_Tnp_ISL3,zf-ISL3 k59_273455_1 1254432.SCE1572_41940 5.44e-56 200.0 COG0419@1|root,COG4717@1|root,COG0419@2|Bacteria,COG4717@2|Bacteria,1MVAW@1224|Proteobacteria,42MYC@68525|delta/epsilon subdivisions,2WJXA@28221|Deltaproteobacteria,2Z2A3@29|Myxococcales 28221|Deltaproteobacteria L AAA domain - - - - - - - - - - - - AAA_27 k59_273455_2 1054213.HMPREF9946_00430 3.88e-77 249.0 COG0420@1|root,COG0420@2|Bacteria,1MXMJ@1224|Proteobacteria,2TUDV@28211|Alphaproteobacteria,2JSRY@204441|Rhodospirillales 204441|Rhodospirillales L Calcineurin-like phosphoesterase - - - ko:K03547 - - - - ko00000,ko03400 - - - Metallophos k59_1117145_2 1056820.KB900630_gene1401 1.52e-14 69.3 2DQ1C@1|root,334BU@2|Bacteria,1NEST@1224|Proteobacteria,1SDHG@1236|Gammaproteobacteria,2PQK8@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_1117145_3 314287.GB2207_09476 4.56e-59 186.0 COG1490@1|root,COG1490@2|Bacteria,1RGTV@1224|Proteobacteria,1S61I@1236|Gammaproteobacteria,1J6AY@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality dtd GO:0002161,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006399,GO:0006450,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0034641,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051499,GO:0051500,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106026,GO:0106074,GO:0140098,GO:0140101,GO:1901360 - ko:K07560 - - - - ko00000,ko01000,ko03016 - - - Tyr_Deacylase k59_1175828_1 639283.Snov_3360 1.03e-62 210.0 COG1835@1|root,COG1835@2|Bacteria,1MV2W@1224|Proteobacteria,2TRT8@28211|Alphaproteobacteria,3F0E6@335928|Xanthobacteraceae 28211|Alphaproteobacteria I Acyltransferase family - - - - - - - - - - - - Acyl_transf_3 k59_896564_1 1415778.JQMM01000001_gene137 7.89e-53 173.0 COG3484@1|root,COG3484@2|Bacteria,1N057@1224|Proteobacteria,1RRR0@1236|Gammaproteobacteria,1J84B@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O Proteasome subunit - - - ko:K07395 - - - - ko00000 - - - Proteasome k59_896564_2 1265313.HRUBRA_01636 3.83e-19 86.3 COG4307@1|root,COG4307@2|Bacteria,1MW31@1224|Proteobacteria,1RRA7@1236|Gammaproteobacteria,1JA5V@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Putative zinc-binding metallo-peptidase - - - - - - - - - - - - Peptidase_Mx,zinc-ribbon_6 k59_1064303_1 1123518.ARWI01000001_gene2449 4.1e-30 124.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,4607S@72273|Thiotrichales 72273|Thiotrichales T nitrogen regulation protein NR(I) - - - ko:K07712 ko02020,map02020 M00497 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_550153_1 566466.NOR53_3278 8.6e-153 455.0 COG0577@1|root,COG0577@2|Bacteria,1NREW@1224|Proteobacteria,1RVN1@1236|Gammaproteobacteria,1J78V@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria V COG0577 ABC-type antimicrobial peptide transport system, permease component - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_947321_1 436308.Nmar_1627 5.21e-91 290.0 COG0209@1|root,arCOG03713@1|root,arCOG03713@2157|Archaea,arCOG04276@2157|Archaea,41SAH@651137|Thaumarchaeota 651137|Thaumarchaeota F Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen - - 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - ATP-cone,Ribonuc_red_lgC,Ribonuc_red_lgN k59_1405011_1 697282.Mettu_1167 1.38e-83 265.0 COG1116@1|root,COG1116@2|Bacteria,1MUDV@1224|Proteobacteria,1RNEH@1236|Gammaproteobacteria,1XEX0@135618|Methylococcales 135618|Methylococcales P TIGRFAM Nitrate transport ATP-binding - - - ko:K15578 ko00910,ko02010,map00910,map02010 M00438 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.16.1 - - ABC_tran k59_273477_1 156889.Mmc1_1634 8.7e-09 60.5 COG0666@1|root,COG0666@2|Bacteria,1RBYV@1224|Proteobacteria,2UA2F@28211|Alphaproteobacteria 28211|Alphaproteobacteria KT ankyrin repeat - - - ko:K15503 - - - - ko00000,ko01009,ko03400 - - - Ank,Ank_2,Ank_3,Ank_4,Ank_5 k59_103851_1 1229909.NSED_08325 3.31e-100 304.0 COG0644@1|root,arCOG00570@2157|Archaea,41SBB@651137|Thaumarchaeota 651137|Thaumarchaeota C Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains - - - - - - - - - - - - - k59_47858_2 1521187.JPIM01000017_gene330 4.7e-61 201.0 COG4962@1|root,COG4962@2|Bacteria,2G68E@200795|Chloroflexi,374Z4@32061|Chloroflexia 32061|Chloroflexia U PFAM type II secretion system protein E - - - ko:K02283 - - - - ko00000,ko02035,ko02044 - - - T2SSE k59_1405024_1 316407.85675460 3.59e-133 393.0 COG0481@1|root,COG0481@2|Bacteria,1MVZA@1224|Proteobacteria,1RPFB@1236|Gammaproteobacteria,3XNWA@561|Escherichia 1236|Gammaproteobacteria J Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner lepA GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0003824,GO:0003924,GO:0005488,GO:0005515,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0006950,GO:0006970,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009266,GO:0009268,GO:0009409,GO:0009628,GO:0009651,GO:0009987,GO:0010467,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019538,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034641,GO:0034645,GO:0035639,GO:0036094,GO:0042802,GO:0043021,GO:0043023,GO:0043024,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0050896,GO:0071704,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576 - ko:K03596 ko05134,map05134 - - - ko00000,ko00001 - - - EFG_C,GTP_EFTU,GTP_EFTU_D2,LepA_C k59_776689_1 1121405.dsmv_3287 3.04e-20 83.2 COG1837@1|root,COG1837@2|Bacteria 2|Bacteria L Belongs to the UPF0109 family CP_0026 - - ko:K06960 - - - - ko00000 - - - KH_4 k59_1286242_1 436308.Nmar_1446 7.89e-48 154.0 COG3432@1|root,arCOG01055@2157|Archaea,41SST@651137|Thaumarchaeota 651137|Thaumarchaeota K Winged helix-turn-helix - - - - - - - - - - - - HTH_45 k59_1574965_1 225937.HP15_4014 1.57e-17 84.7 COG1233@1|root,COG1233@2|Bacteria,1MV2R@1224|Proteobacteria,1RMGJ@1236|Gammaproteobacteria,46C30@72275|Alteromonadaceae 1236|Gammaproteobacteria Q Flavin containing amine oxidoreductase - - 1.3.99.23 ko:K09516 ko00830,map00830 - R07163 RC01835 ko00000,ko00001,ko01000 - - - Amino_oxidase,FAD_binding_6,NAD_binding_1,NAD_binding_8 k59_1175859_1 1122137.AQXF01000004_gene1623 1.71e-129 380.0 COG1396@1|root,COG3800@1|root,COG1396@2|Bacteria,COG3800@2|Bacteria,1MU50@1224|Proteobacteria,2TRKE@28211|Alphaproteobacteria 28211|Alphaproteobacteria K transcriptional regulator - - - ko:K07110 - - - - ko00000,ko03000 - - - DUF2083,HTH_19,HTH_3,HTH_31,Peptidase_M78 k59_1175859_2 1122137.AQXF01000002_gene648 9.63e-26 103.0 COG2355@1|root,COG2355@2|Bacteria,1MWEW@1224|Proteobacteria,2TR5C@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Zn-dependent dipeptidase, microsomal dipeptidase - - 3.4.13.19 ko:K01273 - - - - ko00000,ko00537,ko01000,ko01002,ko04147 - - - Peptidase_M19 k59_388093_1 765913.ThidrDRAFT_1905 7.15e-148 445.0 COG4222@1|root,COG5276@1|root,COG4222@2|Bacteria,COG5276@2|Bacteria,1MVDD@1224|Proteobacteria,1T1Z4@1236|Gammaproteobacteria,1X2K4@135613|Chromatiales 135613|Chromatiales S Esterase-like activity of phytase - - - - - - - - - - - - Phytase-like k59_1342479_1 926556.Echvi_2494 4.14e-14 71.6 COG0446@1|root,COG0446@2|Bacteria,4NER5@976|Bacteroidetes 976|Bacteroidetes S SusD family - - - ko:K21572 - - - - ko00000,ko02000 8.A.46.1,8.A.46.3 - - SusD-like_3,SusD_RagB k59_1342479_2 1353276.JADR01000002_gene2065 4.78e-60 204.0 COG4733@1|root,COG4733@2|Bacteria,4PKH9@976|Bacteroidetes,1IJ8W@117743|Flavobacteriia 976|Bacteroidetes S Concanavalin A-like lectin/glucanases superfamily - - - - - - - - - - - - Laminin_G_3 k59_158225_1 450851.PHZ_c2449 4.75e-11 62.0 COG2272@1|root,COG2272@2|Bacteria,1MVQZ@1224|Proteobacteria,2TTHT@28211|Alphaproteobacteria,2KFIK@204458|Caulobacterales 204458|Caulobacterales I Belongs to the type-B carboxylesterase lipase family - - - ko:K03929 - - - - ko00000,ko01000 - CE10 - COesterase k59_158225_2 1121123.AUAO01000001_gene740 4.08e-82 255.0 COG3971@1|root,COG3971@2|Bacteria,1RB58@1224|Proteobacteria,2U8HR@28211|Alphaproteobacteria,2KGGQ@204458|Caulobacterales 204458|Caulobacterales Q 2-keto-4-pentenoate hydratase - - 4.2.1.80 ko:K02554 ko00360,ko00362,ko00621,ko00622,ko01100,ko01120,ko01220,map00360,map00362,map00621,map00622,map01100,map01120,map01220 M00545,M00569 R02601,R04781 RC00750,RC01213 br01602,ko00000,ko00001,ko00002,ko01000 - - - FAA_hydrolase k59_103900_1 316407.1736471 1.57e-164 478.0 COG0793@1|root,COG0793@2|Bacteria,1MU39@1224|Proteobacteria,1RMSR@1236|Gammaproteobacteria,3XN0R@561|Escherichia 1236|Gammaproteobacteria M Belongs to the peptidase S41A family prc GO:0003674,GO:0003824,GO:0004175,GO:0005575,GO:0005623,GO:0005886,GO:0006508,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0016020,GO:0016787,GO:0019538,GO:0023052,GO:0030163,GO:0030288,GO:0030313,GO:0031975,GO:0042221,GO:0042597,GO:0043170,GO:0044238,GO:0044464,GO:0046677,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901565,GO:1901575 3.4.21.102 ko:K03797 - - - - ko00000,ko01000,ko01002 - - - BAGE,DUF3340,PDZ,Peptidase_S41 k59_896621_1 1349820.M707_12995 2.98e-30 124.0 COG3299@1|root,COG3299@2|Bacteria,2GM5C@201174|Actinobacteria 201174|Actinobacteria S Baseplate J-like protein - - - - - - - - - - - - Baseplate_J,LysM k59_1003040_1 595494.Tola_2050 2.65e-92 290.0 COG0662@1|root,COG0836@1|root,COG0662@2|Bacteria,COG0836@2|Bacteria,1MV39@1224|Proteobacteria,1RNQI@1236|Gammaproteobacteria,1Y3Y6@135624|Aeromonadales 135624|Aeromonadales M mannose-6-phosphate isomerase type - - 2.7.7.13,5.3.1.8 ko:K00971,ko:K16011 ko00051,ko00520,ko01100,ko01110,ko01130,ko02025,map00051,map00520,map01100,map01110,map01130,map02025 M00114,M00361,M00362 R00885,R01819 RC00002,RC00376 ko00000,ko00001,ko00002,ko01000 - - - MannoseP_isomer,NTP_transferase k59_273535_1 316407.85674640 3.6e-60 186.0 COG2801@1|root,COG2801@2|Bacteria,1MZ45@1224|Proteobacteria,1RSNX@1236|Gammaproteobacteria 1236|Gammaproteobacteria L COG2801 Transposase and inactivated derivatives ylbG - - - - - - - - - - - HTH_29,rve,rve_2,rve_3 k59_1117229_1 869213.JCM21142_93856 1.19e-17 88.6 COG2730@1|root,COG4733@1|root,COG5492@1|root,COG2730@2|Bacteria,COG4733@2|Bacteria,COG5492@2|Bacteria,4P0E7@976|Bacteroidetes 976|Bacteroidetes G Belongs to the glycosyl hydrolase 5 (cellulase A) family - - - - - - - - - - - - - k59_726464_1 257313.BP3507 3.17e-09 64.3 COG2199@1|root,COG3706@2|Bacteria,1MVCZ@1224|Proteobacteria,2VNGE@28216|Betaproteobacteria,3T391@506|Alcaligenaceae 28216|Betaproteobacteria T Protoglobin dosC_1 - 2.7.7.65 ko:K13069 - - R08057 - ko00000,ko01000 - - - GGDEF,Protoglobin k59_726464_2 323261.Noc_1691 3.81e-17 75.9 COG0432@1|root,COG0432@2|Bacteria,1RH13@1224|Proteobacteria,1S3VP@1236|Gammaproteobacteria,1WY9X@135613|Chromatiales 135613|Chromatiales S Uncharacterised protein family UPF0047 - - - - - - - - - - - - UPF0047 k59_896627_1 1089553.Tph_c02240 1.75e-16 85.9 COG0845@1|root,COG0845@2|Bacteria,1V2JZ@1239|Firmicutes,24A5A@186801|Clostridia,42GMT@68295|Thermoanaerobacterales 186801|Clostridia M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - ko:K13888 - M00709 - - ko00000,ko00002,ko02000 8.A.1 - - Biotin_lipoyl_2,HlyD_3,HlyD_D23 k59_896627_2 880071.Fleli_0562 5.37e-16 81.6 COG0841@1|root,COG0841@2|Bacteria,4NDZG@976|Bacteroidetes,47K19@768503|Cytophagia 976|Bacteroidetes V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K03296 - - - - ko00000 2.A.6.2 - - ACR_tran k59_1342505_1 1172188.KB911820_gene2577 0.000233 43.5 2FAXM@1|root,3434G@2|Bacteria,2IRD0@201174|Actinobacteria,4FHI7@85021|Intrasporangiaceae 201174|Actinobacteria - - - - - - - - - - - - - - - k59_1405067_1 452637.Oter_4283 1.03e-79 266.0 COG0657@1|root,COG0657@2|Bacteria,46TU9@74201|Verrucomicrobia,3KA3K@414999|Opitutae 414999|Opitutae I Glycosyl hydrolase family 65, N-terminal domain - - 3.2.1.51 ko:K15923 ko00511,map00511 - - - ko00000,ko00001,ko01000 - GH95 - Glyco_hyd_65N_2 k59_1405067_2 926566.Terro_0040 6.58e-19 85.5 COG1028@1|root,COG1028@2|Bacteria,3Y42B@57723|Acidobacteria,2JIWX@204432|Acidobacteriia 204432|Acidobacteriia IQ PFAM Short-chain dehydrogenase reductase SDR - - 1.1.1.100 ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 k59_1231857_1 394221.Mmar10_1282 4.52e-32 127.0 COG0550@1|root,COG1754@1|root,COG0550@2|Bacteria,COG1754@2|Bacteria,1MUFZ@1224|Proteobacteria,2TRGN@28211|Alphaproteobacteria,43WW9@69657|Hyphomonadaceae 28211|Alphaproteobacteria L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone topA - 5.99.1.2 ko:K03168 - - - - ko00000,ko01000,ko03032,ko03400 - - - Topoisom_bac,Toprim,Toprim_C_rpt,zf-C4_Topoisom k59_494612_1 1484460.JSWG01000012_gene1455 3.96e-133 389.0 COG1012@1|root,COG1012@2|Bacteria,4NEB7@976|Bacteroidetes,1HWQG@117743|Flavobacteriia 976|Bacteroidetes C Belongs to the aldehyde dehydrogenase family - - 1.2.1.32,1.2.1.85 ko:K10217 ko00362,ko00380,ko00622,ko01100,ko01120,ko01220,map00362,map00380,map00622,map01100,map01120,map01220 M00038,M00569 R02762,R03889,R05353 RC00218,RC00254 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_494612_2 1392490.JHZX01000001_gene2593 8.87e-59 184.0 COG0251@1|root,COG0251@2|Bacteria,4NMHF@976|Bacteroidetes,1I1II@117743|Flavobacteriia 976|Bacteroidetes J Translation initiation inhibitor, yjgF family - - 3.5.99.5 ko:K15067 ko00380,map00380 - R03887 RC01015 ko00000,ko00001,ko01000 - - - Ribonuc_L-PSP k59_1064360_1 1288494.EBAPG3_14260 3.29e-82 250.0 COG0681@1|root,COG0681@2|Bacteria,1MXUF@1224|Proteobacteria,2VJ9D@28216|Betaproteobacteria,371PT@32003|Nitrosomonadales 28216|Betaproteobacteria U Belongs to the peptidase S26 family lepB - 3.4.21.89 ko:K03100 ko02024,ko03060,map02024,map03060 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_S24,Peptidase_S26 k59_388137_2 1171373.PACID_16340 5.61e-06 48.1 COG1154@1|root,COG1154@2|Bacteria,2GMFA@201174|Actinobacteria,4DNP5@85009|Propionibacteriales 201174|Actinobacteria H Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) dxs - 2.2.1.7 ko:K01662 ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130 M00096 R05636 RC00032 ko00000,ko00001,ko00002,ko01000 - - - DXP_synthase_N,Transket_pyr,Transketolase_C k59_1342532_1 1082933.MEA186_18170 6.1e-25 104.0 COG4638@1|root,COG4638@2|Bacteria,1MWXW@1224|Proteobacteria,2TSJ5@28211|Alphaproteobacteria,43GYK@69277|Phyllobacteriaceae 28211|Alphaproteobacteria P Rieske 2Fe-2S - - - ko:K00479 - - - - ko00000 - - - Rieske,Ring_hydroxyl_A k59_1342532_2 1089547.KB913013_gene367 2.26e-47 164.0 COG0412@1|root,COG0412@2|Bacteria,4PMKB@976|Bacteroidetes,47Y3P@768503|Cytophagia 976|Bacteroidetes Q Dienelactone hydrolase - - - - - - - - - - - - - k59_388143_1 1415778.JQMM01000001_gene1233 2.74e-87 276.0 COG0642@1|root,COG2205@2|Bacteria,1MXF8@1224|Proteobacteria,1RMMI@1236|Gammaproteobacteria,1J5BZ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria T His Kinase A (phosphoacceptor) domain pilS - 2.7.13.3 ko:K02668 ko02020,map02020 M00501 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 - - - HATPase_c,HisKA,PAS_8 k59_103921_1 63737.Npun_F3565 1.47e-27 116.0 COG0515@1|root,COG2203@1|root,COG3899@1|root,COG4251@1|root,COG0515@2|Bacteria,COG2203@2|Bacteria,COG3899@2|Bacteria,COG4251@2|Bacteria,1GQ9E@1117|Cyanobacteria,1HIP0@1161|Nostocales 1117|Cyanobacteria T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - AAA_16,GAF,HATPase_c,HisKA,Pkinase k59_1627731_1 1499968.TCA2_0506 1.51e-20 89.7 COG0783@1|root,COG0783@2|Bacteria,1VCVJ@1239|Firmicutes,4HMBD@91061|Bacilli,26Y9T@186822|Paenibacillaceae 91061|Bacilli P Belongs to the Dps family dps - - ko:K04047 - - - - ko00000,ko03036 - - - Ferritin k59_1231865_1 330214.NIDE3819 5.58e-47 160.0 COG2843@1|root,COG2843@2|Bacteria 2|Bacteria M Bacterial capsule synthesis protein PGA_cap - - - ko:K07282 - - - - ko00000 - - - PGA_cap k59_1231865_2 1123393.KB891316_gene1686 2.27e-06 48.9 COG0617@1|root,COG1371@1|root,COG0617@2|Bacteria,COG1371@2|Bacteria,1MU2X@1224|Proteobacteria,2VIN5@28216|Betaproteobacteria,1KRHG@119069|Hydrogenophilales 119069|Hydrogenophilales J Probable RNA and SrmB- binding site of polymerase A - - 2.7.7.72 ko:K00974 ko03013,map03013 - R09382,R09383,R09384,R09386 RC00078 ko00000,ko00001,ko01000,ko03016 - - - Archease,HD,PolyA_pol,PolyA_pol_RNAbd k59_726489_1 394221.Mmar10_1413 3.08e-123 367.0 COG0148@1|root,COG0148@2|Bacteria,1MU1N@1224|Proteobacteria,2TR04@28211|Alphaproteobacteria,43WMU@69657|Hyphomonadaceae 28211|Alphaproteobacteria G Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis eno - 4.2.1.11 ko:K01689 ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066 M00001,M00002,M00003,M00346,M00394 R00658 RC00349 ko00000,ko00001,ko00002,ko01000,ko03019,ko04147 - - - Enolase_C,Enolase_N k59_1456027_1 316407.85676566 1.11e-189 528.0 COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,1RP7R@1236|Gammaproteobacteria,3XMHP@561|Escherichia 1236|Gammaproteobacteria P Nickel transport system permease protein NikB nikB GO:0000041,GO:0003674,GO:0005215,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008324,GO:0015075,GO:0015099,GO:0015318,GO:0015675,GO:0016020,GO:0016021,GO:0016151,GO:0022857,GO:0022890,GO:0030001,GO:0031224,GO:0031226,GO:0034220,GO:0035444,GO:0043167,GO:0043169,GO:0044425,GO:0044459,GO:0044464,GO:0046872,GO:0046873,GO:0046914,GO:0046915,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098655,GO:0098660,GO:0098662 - ko:K15585 ko02010,map02010 M00440 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - iG2583_1286.G2583_4198 BPD_transp_1 k59_947429_2 1208321.D104_06945 1.51e-106 312.0 COG0081@1|root,COG0081@2|Bacteria,1MUE6@1224|Proteobacteria,1RMDW@1236|Gammaproteobacteria,1XH9B@135619|Oceanospirillales 135619|Oceanospirillales J Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release rplA - - ko:K02863 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L1 k59_331240_1 436308.Nmar_1644 2.31e-85 263.0 arCOG08728@1|root,arCOG08728@2157|Archaea,41SW1@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1517618_1 502025.Hoch_3458 8.84e-74 238.0 COG0518@1|root,COG0519@1|root,COG0518@2|Bacteria,COG0519@2|Bacteria,1MU2A@1224|Proteobacteria,42M0I@68525|delta/epsilon subdivisions,2WJ6D@28221|Deltaproteobacteria,2YTZV@29|Myxococcales 28221|Deltaproteobacteria F Catalyzes the synthesis of GMP from XMP guaA GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046037,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 6.3.5.2 ko:K01951 ko00230,ko00983,ko01100,map00230,map00983,map01100 M00050 R01230,R01231,R08244 RC00010,RC00204 ko00000,ko00001,ko00002,ko01000,ko01002 - - - GATase,GMP_synt_C,NAD_synthase,tRNA_Me_trans k59_1628809_1 158500.BV97_00498 1.53e-96 310.0 COG1197@1|root,COG1197@2|Bacteria,1MUXG@1224|Proteobacteria,2TR2H@28211|Alphaproteobacteria,2K07V@204457|Sphingomonadales 204457|Sphingomonadales L Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site mfd - - ko:K03723 ko03420,map03420 - - - ko00000,ko00001,ko01000,ko03400 - - - CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF k59_1232916_1 269796.Rru_A1641 6.46e-36 129.0 COG1863@1|root,COG1863@2|Bacteria,1MZYJ@1224|Proteobacteria,2UBYN@28211|Alphaproteobacteria,2JTMZ@204441|Rhodospirillales 204441|Rhodospirillales P Na+/H+ ion antiporter subunit - - - ko:K05569 - - - - ko00000,ko02000 2.A.63.1,2.A.63.2 - - MNHE k59_495695_1 203122.Sde_0484 3e-18 82.8 COG0500@1|root,COG2226@2|Bacteria,1R3QX@1224|Proteobacteria,1RYQ8@1236|Gammaproteobacteria,466WF@72275|Alteromonadaceae 1236|Gammaproteobacteria Q Methionine biosynthesis protein MetW - - - - - - - - - - - - Methyltransf_11,Methyltransf_23 k59_495695_2 1042377.AFPJ01000019_gene2529 5.87e-16 78.6 COG0438@1|root,COG0438@2|Bacteria,1N9EV@1224|Proteobacteria,1RYRV@1236|Gammaproteobacteria,46CMH@72275|Alteromonadaceae 1236|Gammaproteobacteria M Glycosyl transferases group 1 gt4G - - - - - - - - - - - Glyco_transf_4,Glycos_transf_1 k59_274611_1 945543.VIBR0546_11567 2.91e-05 50.1 COG0845@1|root,COG0845@2|Bacteria,1NQZ0@1224|Proteobacteria,1RR67@1236|Gammaproteobacteria,1XWM1@135623|Vibrionales 135623|Vibrionales M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - - - - - - - - - - HlyD_D23 k59_274611_2 1415778.JQMM01000001_gene1105 8.71e-09 55.1 COG2236@1|root,COG2236@2|Bacteria,1MXS1@1224|Proteobacteria,1RPSD@1236|Gammaproteobacteria,1JA0C@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria F Phosphoribosyl transferase domain - - - ko:K07101 - - - - ko00000 - - - Pribosyltran k59_440251_1 710687.KI912270_gene732 2.22e-08 60.1 COG0524@1|root,COG0524@2|Bacteria,2GYHF@201174|Actinobacteria,232H8@1762|Mycobacteriaceae 201174|Actinobacteria G PFAM PfkB pfkB - 2.7.1.4 ko:K00847 ko00051,ko00500,ko00520,ko01100,map00051,map00500,map00520,map01100 - R00760,R00867,R03920 RC00002,RC00017 ko00000,ko00001,ko01000 - - - PfkB k59_551306_1 436308.Nmar_0445 4.72e-48 166.0 COG1196@1|root,arCOG00371@2157|Archaea,41T1Y@651137|Thaumarchaeota 651137|Thaumarchaeota D Required for chromosome condensation and partitioning - - - - - - - - - - - - - k59_551306_2 436308.Nmar_0444 3.96e-36 136.0 COG1215@1|root,arCOG01389@2157|Archaea,41SDD@651137|Thaumarchaeota 651137|Thaumarchaeota M Glycosyl transferase family group 2 - - - - - - - - - - - - Glyco_tranf_2_3 k59_897698_2 1415778.JQMM01000001_gene184 8.56e-07 50.4 COG0014@1|root,COG0014@2|Bacteria,1MUGJ@1224|Proteobacteria,1RMAY@1236|Gammaproteobacteria,1J4G6@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate proA GO:0003674,GO:0003824,GO:0004350,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016491,GO:0016620,GO:0016903,GO:0017144,GO:0018130,GO:0019752,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0055114,GO:0055129,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.2.1.41 ko:K00147 ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230 M00015 R03313 RC00684 ko00000,ko00001,ko00002,ko01000 - - iB21_1397.B21_00243,iECBD_1354.ECBD_3376,iECB_1328.ECB_00240,iECD_1391.ECD_00240,iYL1228.KPN_00280 Aldedh k59_507344_2 1122137.AQXF01000002_gene660 2.48e-31 119.0 COG0263@1|root,COG0263@2|Bacteria,1MUBG@1224|Proteobacteria,2TRKB@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate proB - 2.7.2.11 ko:K00931 ko00330,ko00332,ko01100,ko01130,ko01230,map00330,map00332,map01100,map01130,map01230 M00015 R00239 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase,PUA k59_507358_1 1415778.JQMM01000001_gene2074 9.24e-88 270.0 COG1219@1|root,COG1219@2|Bacteria,1MVQK@1224|Proteobacteria,1RN9N@1236|Gammaproteobacteria,1J4N7@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP clpX GO:0000166,GO:0000502,GO:0002020,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009376,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0019899,GO:0019904,GO:0030163,GO:0030164,GO:0030554,GO:0031597,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0035639,GO:0036094,GO:0042623,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0043335,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0051301,GO:0051704,GO:0070011,GO:0071704,GO:0097159,GO:0097367,GO:0097718,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1904949,GO:1905368,GO:1905369 - ko:K03544 ko04112,map04112 - - - ko00000,ko00001,ko03110 - - - AAA_2,ClpB_D2-small,zf-C4_ClpX k59_563459_1 1229909.NSED_01585 2.49e-54 180.0 COG2132@1|root,arCOG03914@2157|Archaea,41S77@651137|Thaumarchaeota 651137|Thaumarchaeota Q PFAM Multicopper oxidase - - - - - - - - - - - - Cu-oxidase_2,Cu-oxidase_3 k59_1805312_2 1123072.AUDH01000001_gene2723 2.58e-36 130.0 COG2025@1|root,COG2025@2|Bacteria,1MUFI@1224|Proteobacteria,2TR10@28211|Alphaproteobacteria,2JPTQ@204441|Rhodospirillales 204441|Rhodospirillales C electron transfer flavoprotein, alpha subunit etfA - - ko:K03522 - - - - ko00000,ko04147 - - - ETF,ETF_alpha k59_1015740_1 99598.Cal7507_1092 7.13e-56 182.0 COG0788@1|root,COG0788@2|Bacteria,1G0SN@1117|Cyanobacteria,1HK5T@1161|Nostocales 1117|Cyanobacteria F Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4) purU - 3.5.1.10 ko:K01433 ko00630,ko00670,map00630,map00670 - R00944 RC00026,RC00111 ko00000,ko00001,ko01000 - - - ACT,Formyl_trans_N k59_1015740_2 330214.NIDE0303 0.000437 42.0 COG0265@1|root,COG0265@2|Bacteria,3J0X9@40117|Nitrospirae 2|Bacteria M Evidence 2a Function of homologous gene experimentally demonstrated in an other organism htrA GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005575,GO:0005623,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0016787,GO:0017171,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043170,GO:0044238,GO:0044464,GO:0070011,GO:0071704,GO:0140096,GO:1901564 3.4.21.107 ko:K04771 ko01503,ko02020,map01503,map02020 M00728 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 - - - PDZ,PDZ_2,Trypsin_2 k59_1355141_1 1485544.JQKP01000001_gene945 3.91e-44 150.0 COG2165@1|root,COG2165@2|Bacteria,1MZ5I@1224|Proteobacteria,2VU7P@28216|Betaproteobacteria,44WII@713636|Nitrosomonadales 28216|Betaproteobacteria NU Type II secretory pathway, pseudopilin - - - - - - - - - - - - - k59_563492_1 378806.STAUR_7568 1.75e-32 134.0 COG0642@1|root,COG0784@1|root,COG2202@1|root,COG2203@1|root,COG3437@1|root,COG0784@2|Bacteria,COG2202@2|Bacteria,COG2203@2|Bacteria,COG2205@2|Bacteria,COG3437@2|Bacteria,1NRP8@1224|Proteobacteria,439AN@68525|delta/epsilon subdivisions,2X4I7@28221|Deltaproteobacteria,2YZ2H@29|Myxococcales 28221|Deltaproteobacteria T Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) - - - - - - - - - - - - GAF_2,HATPase_c,HisKA,PAS_4,Response_reg k59_563504_1 1348657.M622_14795 3.6e-43 151.0 COG0075@1|root,COG0075@2|Bacteria,1PM38@1224|Proteobacteria,2VHNM@28216|Betaproteobacteria,2KVAR@206389|Rhodocyclales 206389|Rhodocyclales E COG0075 Serine-pyruvate aminotransferase archaeal aspartate aminotransferase - - - - - - - - - - - - Aminotran_5 k59_563504_2 1168289.AJKI01000030_gene1194 3.53e-56 182.0 COG1335@1|root,COG1335@2|Bacteria,4NS3S@976|Bacteroidetes,2FXXN@200643|Bacteroidia,3XK20@558415|Marinilabiliaceae 976|Bacteroidetes Q Isochorismatase family - - - - - - - - - - - - Isochorismatase k59_507427_1 1392488.JHZY01000002_gene1423 2.96e-74 232.0 COG0624@1|root,COG0624@2|Bacteria,4NE2G@976|Bacteroidetes,1HY61@117743|Flavobacteriia,2XIY2@283735|Leeuwenhoekiella 976|Bacteroidetes E Peptidase dimerisation domain argE - 3.5.1.16 ko:K01438 ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230 M00028,M00845 R00669,R09107 RC00064,RC00300 ko00000,ko00001,ko00002,ko01000 - - - M20_dimer,Peptidase_M20,Peptidase_M28 k59_563525_1 187272.Mlg_1865 4.06e-90 291.0 COG2844@1|root,COG2844@2|Bacteria,1MV54@1224|Proteobacteria,1RN5T@1236|Gammaproteobacteria,1WWDB@135613|Chromatiales 135613|Chromatiales O Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen glnD - 2.7.7.59 ko:K00990 ko02020,map02020 - - - ko00000,ko00001,ko01000 - - - ACT,DUF294,GlnD_UR_UTase,HD,NTP_transf_2 k59_1015803_1 1384054.N790_10315 1.86e-28 108.0 2DVPK@1|root,32UZW@2|Bacteria,1N372@1224|Proteobacteria,1STEU@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_1015803_2 1122137.AQXF01000002_gene624 3.58e-55 185.0 COG0064@1|root,COG0064@2|Bacteria,1MUKG@1224|Proteobacteria,2TRHX@28211|Alphaproteobacteria 28211|Alphaproteobacteria J Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) gatB GO:0003674,GO:0003824,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564 6.3.5.6,6.3.5.7 ko:K02434 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - GatB_N,GatB_Yqey k59_1355181_1 158500.BV97_05047 7.03e-62 215.0 COG3250@1|root,COG3250@2|Bacteria,1P9KJ@1224|Proteobacteria,2UZ0A@28211|Alphaproteobacteria,2K315@204457|Sphingomonadales 204457|Sphingomonadales G alpha-L-rhamnosidase - - - - - - - - - - - - Glyco_hydro_106 k59_960434_1 1122137.AQXF01000003_gene2142 7.69e-39 136.0 COG3022@1|root,COG3022@2|Bacteria,1MUAF@1224|Proteobacteria,2TS11@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Belongs to the UPF0246 family - - - ko:K09861 - - - - ko00000 - - - H2O2_YaaD k59_960434_2 1122137.AQXF01000003_gene2141 7.76e-73 232.0 COG0477@1|root,COG2814@2|Bacteria,1MW59@1224|Proteobacteria,2TRA3@28211|Alphaproteobacteria 28211|Alphaproteobacteria EGP COG0477 Permeases of the major facilitator superfamily - - - - - - - - - - - - MFS_1 k59_789507_2 1869.MB27_31495 0.000664 41.2 COG0789@1|root,COG0789@2|Bacteria,2IQ62@201174|Actinobacteria,4DF52@85008|Micromonosporales 201174|Actinobacteria K helix_turn_helix, mercury resistance - - - - - - - - - - - - MerR,MerR_1 k59_789508_2 1121091.AUMP01000002_gene2096 1.58e-15 79.0 COG0205@1|root,COG0205@2|Bacteria,1TPF4@1239|Firmicutes,4HAPN@91061|Bacilli 91061|Bacilli F Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis pfkA GO:0003674,GO:0003824,GO:0003872,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006116,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006734,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008443,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016052,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017144,GO:0018130,GO:0019200,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019674,GO:0019693,GO:0019752,GO:0032787,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044262,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046835,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0055114,GO:0061615,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576 2.7.1.11 ko:K00850 ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230 M00001,M00345 R00756,R03236,R03237,R03238,R03239,R04779 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000,ko01009,ko03019 - - iYO844.BSU29190 PFK k59_507463_1 436308.Nmar_0088 1.82e-106 333.0 COG1201@1|root,arCOG00557@2157|Archaea,41S8P@651137|Thaumarchaeota 651137|Thaumarchaeota L DEAD/H associated - - - ko:K03724 - - - - ko00000,ko01000,ko03400 - - - DEAD,DEAD_assoc,Helicase_C k59_507472_1 330214.NIDE1346 1.28e-38 136.0 COG1660@1|root,COG1660@2|Bacteria,3J0IK@40117|Nitrospirae 40117|Nitrospirae S Displays ATPase and GTPase activities - - - ko:K06958 - - - - ko00000,ko03019 - - - ATP_bind_2 k59_507472_2 580332.Slit_0435 3.25e-16 77.4 COG1544@1|root,COG1544@2|Bacteria,1MZHW@1224|Proteobacteria,2VU5H@28216|Betaproteobacteria,44W0Q@713636|Nitrosomonadales 28216|Betaproteobacteria J PFAM sigma 54 modulation protein ribosomal protein S30EA raiA - - ko:K05808 - - - - ko00000,ko03009 - - - Ribosomal_S30AE k59_789528_1 1328313.DS2_19031 1.04e-13 71.2 COG0811@1|root,COG0811@2|Bacteria,1RJQC@1224|Proteobacteria,1S6C3@1236|Gammaproteobacteria,46B8R@72275|Alteromonadaceae 1236|Gammaproteobacteria U MotA/TolQ/ExbB proton channel family - - - - - - - - - - - - MotA_ExbB k59_789528_2 298386.PBPRA1535 1.82e-20 94.4 COG1629@1|root,COG4771@2|Bacteria,1MX42@1224|Proteobacteria,1RQ2K@1236|Gammaproteobacteria,1XUY7@135623|Vibrionales 135623|Vibrionales P COG1629 Outer membrane receptor proteins, mostly Fe transport hutA - - ko:K16087 - - - - ko00000,ko02000 1.B.14.2 - - Plug,TonB_dep_Rec k59_789529_1 1415778.JQMM01000001_gene119 1.02e-101 321.0 COG5009@1|root,COG5009@2|Bacteria,1MU5A@1224|Proteobacteria,1RM7J@1236|Gammaproteobacteria,1J4BX@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M penicillin-binding protein mrcA GO:0000270,GO:0003674,GO:0003824,GO:0004180,GO:0004185,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006022,GO:0006023,GO:0006024,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0008238,GO:0008360,GO:0008658,GO:0008955,GO:0009002,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016021,GO:0016740,GO:0016757,GO:0016758,GO:0016787,GO:0017171,GO:0019538,GO:0022603,GO:0022604,GO:0030203,GO:0031224,GO:0031226,GO:0031406,GO:0033218,GO:0033293,GO:0034645,GO:0036094,GO:0042221,GO:0042546,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044425,GO:0044459,GO:0044464,GO:0046677,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051128,GO:0065007,GO:0065008,GO:0070008,GO:0070011,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:0097159,GO:0140096,GO:1901135,GO:1901137,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901681 2.4.1.129,3.4.16.4 ko:K05366 ko00550,ko01100,ko01501,map00550,map01100,map01501 - - - ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 - PCB_OB,Transgly,Transpeptidase k59_789531_1 1144305.PMI02_05421 1.84e-89 287.0 COG2307@1|root,COG2308@1|root,COG2307@2|Bacteria,COG2308@2|Bacteria,1MX5P@1224|Proteobacteria,2TRJE@28211|Alphaproteobacteria,2JZVX@204457|Sphingomonadales 204457|Sphingomonadales S Circularly permuted ATP-grasp type 2 - - - - - - - - - - - - Alpha-E,CP_ATPgrasp_2 k59_1355228_1 1219035.NT2_12_00100 2.1e-114 332.0 COG0081@1|root,COG0081@2|Bacteria,1MUE6@1224|Proteobacteria,2TRXP@28211|Alphaproteobacteria,2K0YM@204457|Sphingomonadales 204457|Sphingomonadales J Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release rplA - - ko:K02863 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L1 k59_563608_1 380358.XALC_2192 1.89e-49 167.0 COG0744@1|root,COG0744@2|Bacteria,1RDAQ@1224|Proteobacteria,1RMGB@1236|Gammaproteobacteria,1X4AQ@135614|Xanthomonadales 135614|Xanthomonadales M Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors mtgA - 2.4.1.129 ko:K03814 ko00550,map00550 - - - ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 - Transgly k59_507541_1 1229909.NSED_09410 1.88e-149 429.0 COG0520@1|root,arCOG00065@2157|Archaea,41SYH@651137|Thaumarchaeota 651137|Thaumarchaeota E Aminotransferase class-V - - 2.8.1.7,4.4.1.16 ko:K11717 ko00450,ko01100,map00450,map01100 - R03599,R11528 RC00961,RC01789,RC02313 ko00000,ko00001,ko01000 - - - Aminotran_5 k59_507541_2 1229909.NSED_09415 8.14e-51 170.0 arCOG08028@1|root,arCOG08028@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_563641_1 685035.ADAE01000002_gene2417 3.38e-113 340.0 COG0591@1|root,COG0591@2|Bacteria,1MUBI@1224|Proteobacteria,2VF3C@28211|Alphaproteobacteria,2KDVP@204457|Sphingomonadales 204457|Sphingomonadales E Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family - - - ko:K03307 - - - - ko00000 2.A.21 - - SSF k59_1355280_1 926550.CLDAP_10530 1.3e-06 57.0 COG0457@1|root,COG0823@1|root,COG0457@2|Bacteria,COG0823@2|Bacteria,2G8PZ@200795|Chloroflexi 200795|Chloroflexi U WD40 domain protein beta Propeller - - - ko:K03641 - - - - ko00000,ko02000 2.C.1.2 - - PD40 k59_1355284_1 396588.Tgr7_0263 2.59e-77 249.0 COG0018@1|root,COG0018@2|Bacteria,1MU4J@1224|Proteobacteria,1RPRC@1236|Gammaproteobacteria,1WVYV@135613|Chromatiales 135613|Chromatiales J Arginyl-tRNA synthetase argS - 6.1.1.19 ko:K01887 ko00970,map00970 M00359,M00360 R03646 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d k59_789629_1 370438.PTH_1951 1.58e-05 50.4 COG0566@1|root,COG0566@2|Bacteria,1V3JP@1239|Firmicutes,248DV@186801|Clostridia,261RV@186807|Peptococcaceae 186801|Clostridia J Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family spoU - - ko:K03437 - - - - ko00000,ko03016 - - - SpoU_methylase,SpoU_sub_bind k59_789629_2 633131.TR2A62_3019 1.25e-24 98.6 COG1250@1|root,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,2TR8E@28211|Alphaproteobacteria 28211|Alphaproteobacteria I 3-hydroxyacyl-coa dehydrogenase bhbD - 1.1.1.157 ko:K00074 ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120 - R01976,R05576,R06941 RC00029,RC00117 ko00000,ko00001,ko01000 - - - 3HCDH,3HCDH_N k59_1355317_2 1131266.ARWQ01000001_gene1245 5.73e-13 67.8 COG1378@1|root,arCOG02038@2157|Archaea,41SFR@651137|Thaumarchaeota 651137|Thaumarchaeota K Archaeal transcriptional regulator TrmB - - - - - - - - - - - - Regulator_TrmB,TrmB k59_507621_2 999411.HMPREF1092_01949 1.24e-76 241.0 COG1131@1|root,COG1131@2|Bacteria,1TPMQ@1239|Firmicutes,248QD@186801|Clostridia,36DTX@31979|Clostridiaceae 186801|Clostridia V ABC transporter sagG - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_563724_1 575540.Isop_2595 1.55e-19 89.0 COG0205@1|root,COG0205@2|Bacteria,2IYE1@203682|Planctomycetes 203682|Planctomycetes G Phosphofructokinase - - - - - - - - - - - - PFK k59_563724_2 1227495.C487_09827 1.08e-23 108.0 COG2352@1|root,arCOG06225@2157|Archaea,2XV0W@28890|Euryarchaeota,23SCE@183963|Halobacteria 183963|Halobacteria C phosphoenolpyruvate carboxylase - - - - - - - - - - - - PEPcase k59_507624_1 1232437.KL662039_gene2083 8.06e-44 153.0 COG1989@1|root,COG1989@2|Bacteria,1MUZF@1224|Proteobacteria,42S2A@68525|delta/epsilon subdivisions,2WMQ8@28221|Deltaproteobacteria,2MJAD@213118|Desulfobacterales 28221|Deltaproteobacteria NOU Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue pilD - 3.4.23.43 ko:K02654 - M00331 - - ko00000,ko00002,ko01000,ko01002,ko02035,ko02044 3.A.15.2 - - DiS_P_DiS,Peptidase_A24 k59_507624_2 330214.NIDE3434 1.95e-47 164.0 COG1277@1|root,COG1277@2|Bacteria 2|Bacteria - - pilI - - - - - - - - - - - ABC2_membrane_2 k59_563733_2 1283300.ATXB01000001_gene490 6.43e-13 73.2 COG1570@1|root,COG1570@2|Bacteria,1MUA4@1224|Proteobacteria,1RNAZ@1236|Gammaproteobacteria,1XE33@135618|Methylococcales 135618|Methylococcales L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides xseA - 3.1.11.6 ko:K03601 ko03430,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - Exonuc_VII_L,tRNA_anti_2 k59_507638_1 1118235.CAJH01000044_gene2785 3.91e-65 222.0 COG2812@1|root,COG2812@2|Bacteria,1MVCK@1224|Proteobacteria,1RMIA@1236|Gammaproteobacteria,1X32S@135614|Xanthomonadales 135614|Xanthomonadales L DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity dnaX - 2.7.7.7 ko:K02343 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_delta2,DNA_pol3_gamma3,DNA_pol3_tau_5 k59_507658_1 391587.KAOT1_18687 1.05e-50 170.0 28J46@1|root,2Z906@2|Bacteria,4NFYM@976|Bacteroidetes,1HX14@117743|Flavobacteriia 976|Bacteroidetes S Protein of unknown function (DUF3078) - - - - - - - - - - - - DUF3078 k59_507658_2 1121931.AUHG01000010_gene100 7.6e-68 217.0 COG2262@1|root,COG2262@2|Bacteria,4NF0P@976|Bacteroidetes,1HXBZ@117743|Flavobacteriia 976|Bacteroidetes S GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis hflX - - ko:K03665 - - - - ko00000,ko03009 - - - GTP-bdg_M,GTP-bdg_N,MMR_HSR1 k59_1527026_2 1286632.P278_03550 3.95e-60 187.0 COG0222@1|root,COG0222@2|Bacteria,4NQAQ@976|Bacteroidetes,1I1Y0@117743|Flavobacteriia 976|Bacteroidetes J Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation rplL - - ko:K02935 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L12,Ribosomal_L12_N k59_1074825_1 95619.PM1_0207935 9.68e-87 269.0 COG1611@1|root,COG1611@2|Bacteria,1MVQJ@1224|Proteobacteria,1RQHX@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Rossmann fold nucleotide-binding protein ygdH GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016787,GO:0016798,GO:0016799,GO:0044424,GO:0044444,GO:0044464,GO:0047405 3.2.2.10 ko:K06966 ko00230,ko00240,map00230,map00240 - R00182,R00510 RC00063,RC00318 ko00000,ko00001,ko01000 - - - DUF3412,DUF4478,Lysine_decarbox k59_1470589_1 1381123.AYOD01000064_gene1537 1.37e-17 88.6 COG1638@1|root,COG1638@2|Bacteria,1MVHI@1224|Proteobacteria,2TQVT@28211|Alphaproteobacteria,43JB5@69277|Phyllobacteriaceae 28211|Alphaproteobacteria G Bacterial extracellular solute-binding protein, family 7 dctP_1 - - - - - - - - - - - DctP k59_1527032_1 345341.KUTG_00208 2.63e-17 83.2 COG0454@1|root,COG4319@1|root,COG0456@2|Bacteria,COG4319@2|Bacteria,2GQGN@201174|Actinobacteria,4E6J0@85010|Pseudonocardiales 201174|Actinobacteria K FR47-like protein - - - - - - - - - - - - Acetyltransf_1 k59_1527032_2 1041826.FCOL_07050 2.69e-32 117.0 COG0745@1|root,COG0745@2|Bacteria,4NF1I@976|Bacteroidetes,1HYAN@117743|Flavobacteriia,2NSW7@237|Flavobacterium 976|Bacteroidetes T Transcriptional regulator rprY - - - - - - - - - - - Response_reg,Trans_reg_C k59_962047_2 1304872.JAGC01000003_gene3619 4.28e-155 447.0 COG0399@1|root,COG0399@2|Bacteria,1MUPN@1224|Proteobacteria,42MTX@68525|delta/epsilon subdivisions,2WITE@28221|Deltaproteobacteria,2M8SG@213115|Desulfovibrionales 28221|Deltaproteobacteria E Belongs to the DegT DnrJ EryC1 family arnB - - - - - - - - - - - DegT_DnrJ_EryC1 k59_623062_1 1278073.MYSTI_04123 1.05e-109 332.0 COG0539@1|root,COG0539@2|Bacteria,1MVAV@1224|Proteobacteria,42M29@68525|delta/epsilon subdivisions,2WJ0X@28221|Deltaproteobacteria,2YU9B@29|Myxococcales 28221|Deltaproteobacteria J thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence rpsA - - ko:K02945 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - S1 k59_510073_1 1144275.COCOR_04784 4.06e-19 87.8 COG0045@1|root,COG1042@1|root,COG1670@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,COG1670@2|Bacteria,1MW98@1224|Proteobacteria,42KZW@68525|delta/epsilon subdivisions,2WIQB@28221|Deltaproteobacteria,2YY8V@29|Myxococcales 28221|Deltaproteobacteria CJ CoA binding domain acs - - ko:K09181 - - - - ko00000 - - - ATP-grasp_5,Acetyltransf_1,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig k59_510073_2 1267534.KB906754_gene3071 4.81e-25 103.0 COG0476@1|root,COG0476@2|Bacteria,3Y2HZ@57723|Acidobacteria,2JHXP@204432|Acidobacteriia 204432|Acidobacteriia H MoeZ MoeB - - 2.7.7.80 ko:K21029 ko04122,map04122 - R07459 RC00043 ko00000,ko00001,ko01000 - - - ThiF k59_1470604_1 323848.Nmul_A1854 2.82e-82 253.0 COG2890@1|root,COG2890@2|Bacteria,1MX8Q@1224|Proteobacteria,2VIPK@28216|Betaproteobacteria,371MJ@32003|Nitrosomonadales 28216|Betaproteobacteria J Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue prmB - 2.1.1.298 ko:K07320 - - R10806 RC00003,RC03279 ko00000,ko01000,ko03009 - - - MTS k59_1752875_1 640081.Dsui_1393 4.09e-137 403.0 COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,2VHQ1@28216|Betaproteobacteria,2KUQA@206389|Rhodocyclales 206389|Rhodocyclales NU Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB - - - ko:K02454,ko:K02652 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02035,ko02044 3.A.15,3.A.15.2 - - T2SSE,T2SSE_N k59_1074839_1 760192.Halhy_2465 1.34e-24 107.0 COG1529@1|root,COG1529@2|Bacteria,4NFFU@976|Bacteroidetes,1IPWF@117747|Sphingobacteriia 976|Bacteroidetes C COG1529 Aerobic-type carbon monoxide dehydrogenase large subunit CoxL CutL homologs - - 1.3.99.16 ko:K07303 - - - - ko00000,ko01000 - - - Ald_Xan_dh_C2 k59_1610_1 572477.Alvin_1908 9.41e-57 181.0 COG0757@1|root,COG0757@2|Bacteria,1RDDT@1224|Proteobacteria,1S3PX@1236|Gammaproteobacteria,1WY3G@135613|Chromatiales 135613|Chromatiales E Catalyzes a trans-dehydration via an enolate intermediate aroQ - 4.2.1.10 ko:K03786 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R03084 RC00848 ko00000,ko00001,ko00002,ko01000 - - - DHquinase_II k59_962061_1 1117647.M5M_14625 2.55e-06 45.8 COG1826@1|root,COG1826@2|Bacteria,1N6S4@1224|Proteobacteria,1SCC7@1236|Gammaproteobacteria,1J788@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system tatA GO:0002790,GO:0003674,GO:0005215,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008565,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0032940,GO:0033036,GO:0034613,GO:0042886,GO:0045184,GO:0046903,GO:0046907,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0070727,GO:0071702,GO:0071705 - ko:K03116 ko03060,ko03070,map03060,map03070 M00336 - - ko00000,ko00001,ko00002,ko02044 2.A.64 - - MttA_Hcf106 k59_962061_2 1479237.JMLY01000001_gene17 2.81e-41 139.0 COG0140@1|root,COG0140@2|Bacteria,1MZEE@1224|Proteobacteria,1S8R4@1236|Gammaproteobacteria,467UR@72275|Alteromonadaceae 1236|Gammaproteobacteria E COG0140 Phosphoribosyl-ATP pyrophosphohydrolase hisE GO:0000105,GO:0003674,GO:0003824,GO:0004636,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 3.6.1.31 ko:K01523 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04035 RC00002 ko00000,ko00001,ko00002,ko01000 - - - PRA-PH k59_962061_3 498211.CJA_0745 8.89e-58 181.0 COG0139@1|root,COG0139@2|Bacteria,1MW67@1224|Proteobacteria,1RMV4@1236|Gammaproteobacteria,1FHBN@10|Cellvibrio 1236|Gammaproteobacteria E Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP hisI GO:0000105,GO:0003674,GO:0003824,GO:0004635,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016787,GO:0016810,GO:0016814,GO:0018130,GO:0019238,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 3.5.4.19,3.6.1.31 ko:K01496,ko:K11755 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04035,R04037 RC00002,RC01055 ko00000,ko00001,ko00002,ko01000 - - iJN746.PP_5014 PRA-CH,PRA-PH k59_1583422_2 1229909.NSED_08035 3.54e-32 119.0 COG0720@1|root,arCOG02172@2157|Archaea,41SY8@651137|Thaumarchaeota 651137|Thaumarchaeota H 6-pyruvoyl tetrahydropterin synthase - - 4.1.2.50,4.2.3.12 ko:K01737 ko00790,ko01100,map00790,map01100 M00842,M00843 R04286,R09959 RC01117,RC02846,RC02847 ko00000,ko00001,ko00002,ko01000,ko03016 - - - PTPS k59_1188022_1 637389.Acaty_c2639 1.44e-29 114.0 COG2095@1|root,COG2095@2|Bacteria,1MX5T@1224|Proteobacteria,1RPZ3@1236|Gammaproteobacteria,2NBZ5@225057|Acidithiobacillales 225057|Acidithiobacillales U MarC family integral membrane protein - - - ko:K05595 - - - - ko00000,ko02000 2.A.95.1 - - MarC k59_1188022_2 313589.JNB_06974 2.27e-26 116.0 COG4552@1|root,COG4552@2|Bacteria,2GNXZ@201174|Actinobacteria,4FIY2@85021|Intrasporangiaceae 201174|Actinobacteria S Sterol carrier protein domain - - - - - - - - - - - - Acetyltransf_9,SCP2_2 k59_1074842_1 886293.Sinac_5064 1.52e-42 152.0 COG2407@1|root,COG2407@2|Bacteria,2IXT8@203682|Planctomycetes 203682|Planctomycetes G Converts the aldose L-fucose into the corresponding ketose L-fuculose - - - - - - - - - - - - - k59_1074842_2 1122132.AQYH01000004_gene1711 3.2e-07 54.3 COG0697@1|root,COG0697@2|Bacteria,1R5PP@1224|Proteobacteria,2TV66@28211|Alphaproteobacteria,4B7R6@82115|Rhizobiaceae 28211|Alphaproteobacteria EG EamA-like transporter family ribN - - ko:K15270 - - - - ko00000,ko02000 2.A.7.3.7 - - EamA k59_736229_1 316274.Haur_0628 3.14e-93 289.0 COG0260@1|root,COG0260@2|Bacteria,2G617@200795|Chloroflexi,37528@32061|Chloroflexia 32061|Chloroflexia E Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides pepA - 3.4.11.1 ko:K01255 ko00480,ko01100,map00480,map01100 - R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 - - - Peptidase_M17,Peptidase_M17_N k59_792759_1 626887.J057_16745 1.85e-86 285.0 COG0823@1|root,COG0823@2|Bacteria,1R3VN@1224|Proteobacteria,1RNKG@1236|Gammaproteobacteria,46408@72275|Alteromonadaceae 1236|Gammaproteobacteria U COG0823 Periplasmic component of the Tol biopolymer transport system - - - - - - - - - - - - PD40 k59_1470618_1 1397527.Q670_14645 3.75e-65 220.0 COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,1RNBG@1236|Gammaproteobacteria,1XI69@135619|Oceanospirillales 135619|Oceanospirillales L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity polA - 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1 k59_171387_1 1320556.AVBP01000014_gene1087 4.55e-53 193.0 COG2887@1|root,COG3893@1|root,COG2887@2|Bacteria,COG3893@2|Bacteria,1MY2G@1224|Proteobacteria,2TS74@28211|Alphaproteobacteria,43H1J@69277|Phyllobacteriaceae 28211|Alphaproteobacteria L double-strand break repair protein AddB addB - 3.6.4.12 ko:K16899 - - - - ko00000,ko01000,ko03400 - - - PDDEXK_1 k59_792762_1 1408418.JNJH01000018_gene837 4.62e-21 86.3 COG5304@1|root,COG5304@2|Bacteria,1N8EP@1224|Proteobacteria,2UH48@28211|Alphaproteobacteria 28211|Alphaproteobacteria S CopG antitoxin of type II toxin-antitoxin system - - - - - - - - - - - - CopG_antitoxin k59_736232_1 1229909.NSED_07540 5.68e-39 139.0 COG0731@1|root,arCOG00953@2157|Archaea 2157|Archaea C Radical SAM domain protein rlmN - 2.1.1.192 ko:K06941 - - - - ko00000,ko01000,ko03009 - - - Fer4_14,Radical_SAM k59_736232_2 1229909.NSED_03370 9.69e-130 380.0 COG1262@1|root,arCOG03517@2157|Archaea,41T1B@651137|Thaumarchaeota 651137|Thaumarchaeota S DinB superfamily - - - - - - - - - - - - DinB_2,FGE-sulfatase k59_340787_1 930166.CD58_00820 1.1e-16 89.4 COG2303@1|root,COG2303@2|Bacteria,1MU3F@1224|Proteobacteria,1RPBQ@1236|Gammaproteobacteria 1236|Gammaproteobacteria E COG2303 Choline dehydrogenase and related flavoproteins - - 1.1.5.9 ko:K19813 ko00030,ko01100,ko01110,ko01130,map00030,map01100,map01110,map01130 - R00305 RC00066 ko00000,ko00001,ko01000 - - - FAD_binding_2,GMC_oxred_C,GMC_oxred_N,NAD_binding_8 k59_114788_1 521719.ATXQ01000009_gene906 4.22e-79 244.0 COG0189@1|root,COG0189@2|Bacteria,1MVUA@1224|Proteobacteria,1RMU0@1236|Gammaproteobacteria,1YDNY@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria H Belongs to the prokaryotic GSH synthase family gshB GO:0000287,GO:0003674,GO:0003824,GO:0004363,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006518,GO:0006575,GO:0006749,GO:0006750,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0019184,GO:0034641,GO:0042398,GO:0043043,GO:0043167,GO:0043169,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0051186,GO:0051188,GO:0071704,GO:1901564,GO:1901566,GO:1901576 6.3.2.3 ko:K01920 ko00270,ko00480,ko01100,map00270,map00480,map01100 M00118 R00497,R10994 RC00096,RC00141 ko00000,ko00001,ko00002,ko01000 - - iECED1_1282.ECED1_3410,iECP_1309.ECP_2941 GSH-S_ATP,GSH-S_N k59_1244679_1 1046627.BZARG_1408 2.07e-88 282.0 COG1198@1|root,COG1198@2|Bacteria,4NFHB@976|Bacteroidetes,1HWZJ@117743|Flavobacteriia 976|Bacteroidetes L Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA priA - - ko:K04066 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,Helicase_C,ResIII k59_1244679_2 504487.JCM19302_461 1.82e-25 99.8 COG3279@1|root,COG3279@2|Bacteria,4NFN4@976|Bacteroidetes,1HYAZ@117743|Flavobacteriia 976|Bacteroidetes KT Response regulator of the LytR AlgR family - - - - - - - - - - - - LytTR,Response_reg k59_566851_1 588581.Cpap_1885 3.22e-16 87.8 COG1472@1|root,COG1472@2|Bacteria,1TP63@1239|Firmicutes,24YIP@186801|Clostridia,3WG7U@541000|Ruminococcaceae 186801|Clostridia G Hydrolase Family 3 - - 3.2.1.52 ko:K01207 ko00520,ko00531,ko01100,ko01501,map00520,map00531,map01100,map01501 M00628 R00022,R05963,R07809,R07810,R10831 RC00049 ko00000,ko00001,ko00002,ko01000 - - - Glyco_hydro_3 k59_1188067_1 400668.Mmwyl1_2456 3.96e-129 377.0 COG0006@1|root,COG0006@2|Bacteria,1MWUT@1224|Proteobacteria,1RZSD@1236|Gammaproteobacteria,1XHVN@135619|Oceanospirillales 135619|Oceanospirillales E Creatinase/Prolidase N-terminal domain - - 3.4.13.9 ko:K01271 - - - - ko00000,ko01000,ko01002 - - - Creatinase_N,Peptidase_M24 k59_10450_1 51337.XP_004668167.1 0.000263 48.9 COG0365@1|root,KOG1175@2759|Eukaryota,38BR4@33154|Opisthokonta,3BE2N@33208|Metazoa,3CRVF@33213|Bilateria,483VQ@7711|Chordata,49728@7742|Vertebrata,3J64C@40674|Mammalia,35K1B@314146|Euarchontoglires,4Q1KM@9989|Rodentia 33208|Metazoa I Acetyl-coenzyme A synthetase, cytoplasmic ACSS2 GO:0000166,GO:0003674,GO:0003824,GO:0003987,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005759,GO:0005829,GO:0006066,GO:0006067,GO:0006069,GO:0006082,GO:0006083,GO:0006084,GO:0006085,GO:0006091,GO:0006139,GO:0006163,GO:0006164,GO:0006629,GO:0006631,GO:0006633,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0007610,GO:0008144,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009636,GO:0009987,GO:0010033,GO:0015645,GO:0016053,GO:0016208,GO:0016405,GO:0016874,GO:0016877,GO:0016878,GO:0016999,GO:0017000,GO:0017076,GO:0017144,GO:0018130,GO:0019413,GO:0019438,GO:0019541,GO:0019542,GO:0019637,GO:0019693,GO:0019752,GO:0030534,GO:0030554,GO:0031974,GO:0031981,GO:0032501,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034308,GO:0034641,GO:0034654,GO:0035383,GO:0035384,GO:0036094,GO:0042221,GO:0042493,GO:0043167,GO:0043168,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044428,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0045471,GO:0046390,GO:0046394,GO:0046459,GO:0046483,GO:0046677,GO:0048149,GO:0050896,GO:0051186,GO:0051188,GO:0051790,GO:0055086,GO:0055114,GO:0070013,GO:0071616,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097305,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901700 6.2.1.1 ko:K01895 ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200 M00357 R00235,R00236,R00316,R00926,R01354 RC00004,RC00012,RC00043,RC00070,RC02746,RC02816 ko00000,ko00001,ko00002,ko01000,ko01004 - - - ACAS_N,AMP-binding,AMP-binding_C k59_1479684_1 859657.RPSI07_1651 6.05e-99 300.0 COG2873@1|root,COG2873@2|Bacteria,1NQME@1224|Proteobacteria,2VHYA@28216|Betaproteobacteria,1K1VP@119060|Burkholderiaceae 28216|Betaproteobacteria E o-acetylhomoserine metY - 2.5.1.49 ko:K01740 ko00270,ko01100,map00270,map01100 - R01287,R04859 RC00020,RC02821,RC02848 ko00000,ko00001,ko01000 - - - Cys_Met_Meta_PP k59_10457_1 1122137.AQXF01000001_gene2863 1.76e-107 312.0 COG0634@1|root,COG0634@2|Bacteria,1NRT8@1224|Proteobacteria,2TTN7@28211|Alphaproteobacteria 28211|Alphaproteobacteria F Belongs to the purine pyrimidine phosphoribosyltransferase family hpt GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.4.2.8 ko:K00760 ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 - R00190,R01132,R01229,R02142,R08237,R08238,R08245 RC00063,RC00122 ko00000,ko00001,ko01000 - - - Pribosyltran k59_1253340_1 158500.BV97_03907 3.73e-114 338.0 COG0527@1|root,COG0527@2|Bacteria,1MW3H@1224|Proteobacteria,2TRFA@28211|Alphaproteobacteria,2K044@204457|Sphingomonadales 204457|Sphingomonadales E Belongs to the aspartokinase family lysC - 2.7.2.4 ko:K00928 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00017,M00018,M00033,M00525,M00526,M00527 R00480 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase,ACT,ACT_7 k59_462190_1 685778.AORL01000004_gene3447 1.56e-58 199.0 COG0491@1|root,COG0491@2|Bacteria 2|Bacteria GM Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid - - - - - - - - - - - - Lactamase_B k59_1139995_1 864051.BurJ1DRAFT_2684 8.37e-136 396.0 28I8B@1|root,2Z8B5@2|Bacteria,1MUNM@1224|Proteobacteria,2VKHA@28216|Betaproteobacteria,1KN5Z@119065|unclassified Burkholderiales 28216|Betaproteobacteria P Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - - - - - - - - - - Cytochrome_C554,Cytochrome_cB k59_1479701_1 436308.Nmar_1228 3.52e-43 143.0 COG2164@1|root,arCOG04488@2157|Archaea,41T6P@651137|Thaumarchaeota 651137|Thaumarchaeota S Cyclophilin-like - - - ko:K09143 - - - - ko00000 - - - Cyclophil_like k59_1479701_2 436308.Nmar_1227 2.04e-49 161.0 COG1310@1|root,arCOG01138@2157|Archaea,41SSV@651137|Thaumarchaeota 651137|Thaumarchaeota S metal-dependent protease of the PAD1 JAB1 superfamily - - 3.13.1.6 ko:K21140 ko04122,map04122 - R11524 RC00064,RC00090 ko00000,ko00001,ko01000 - - - Prok-JAB k59_1253356_1 1190606.AJYG01000016_gene3419 4.93e-41 155.0 COG5000@1|root,COG5001@1|root,COG5000@2|Bacteria,COG5001@2|Bacteria,1QXXY@1224|Proteobacteria,1T5JT@1236|Gammaproteobacteria,1XYJ1@135623|Vibrionales 135623|Vibrionales T Cache domain - - - - - - - - - - - - GGDEF,dCache_1 k59_1083610_1 13690.CP98_01839 9.12e-62 199.0 COG1309@1|root,COG1309@2|Bacteria,1Q53U@1224|Proteobacteria,2UPD9@28211|Alphaproteobacteria,2K556@204457|Sphingomonadales 204457|Sphingomonadales K Bacterial regulatory proteins, tetR family - - - - - - - - - - - - TetR_N k59_801566_1 553385.JEMF01000021_gene3131 4.74e-34 128.0 COG0540@1|root,COG0540@2|Bacteria,1MWAB@1224|Proteobacteria,1RPSV@1236|Gammaproteobacteria,1XIZ1@135619|Oceanospirillales 135619|Oceanospirillales F Belongs to the ATCase OTCase family pyrB - 2.1.3.2 ko:K00609 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R01397 RC00064,RC02850 ko00000,ko00001,ko00002,ko01000 - - - OTCace,OTCace_N k59_801566_2 1049564.TevJSym_bn00150 9.05e-13 67.8 COG0543@1|root,COG0543@2|Bacteria,1RF43@1224|Proteobacteria,1RQ7W@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) - - - ko:K02823 ko00240,ko01100,map00240,map01100 - - - ko00000,ko00001 - - - DHODB_Fe-S_bind,FAD_binding_6 k59_1648615_1 1237149.C900_02632 4.96e-07 50.8 COG4095@1|root,COG4095@2|Bacteria 2|Bacteria S Sugar efflux transporter for intercellular exchange - - - ko:K15383 - - - - ko00000,ko02000 9.A.58.2 - - MtN3_slv,PQ-loop k59_688086_1 1144305.PMI02_02991 1.05e-69 211.0 2AI3K@1|root,318HD@2|Bacteria,1N501@1224|Proteobacteria,2UIA7@28211|Alphaproteobacteria,2K6AH@204457|Sphingomonadales 204457|Sphingomonadales S PilZ domain - - - - - - - - - - - - PilZ k59_462221_1 1333998.M2A_2211 2.36e-66 219.0 COG4799@1|root,COG4799@2|Bacteria,1MVAX@1224|Proteobacteria,2TTB9@28211|Alphaproteobacteria,4BT9B@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria I Carboxyl transferase domain - - - - - - - - - - - - Carboxyl_trans k59_405728_1 436308.Nmar_0533 1.43e-22 92.8 arCOG08681@1|root,arCOG08681@2157|Archaea,41SH9@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_405728_2 1229909.NSED_05045 5e-49 159.0 arCOG08730@1|root,arCOG08730@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_462228_1 1120949.KB903358_gene5264 8.51e-20 94.4 COG2366@1|root,COG2366@2|Bacteria,2GISQ@201174|Actinobacteria,4DBHN@85008|Micromonosporales 201174|Actinobacteria S PFAM peptidase S45 penicillin amidase - - 3.5.1.11 ko:K01434 ko00311,ko01130,map00311,map01130 - R02170 RC00166,RC00328 ko00000,ko00001,ko01000,ko01002 - - - Penicil_amidase k59_1367387_1 1123504.JQKD01000040_gene2802 5.9e-14 71.6 COG0745@1|root,COG0745@2|Bacteria,1N7TJ@1224|Proteobacteria,2VNCP@28216|Betaproteobacteria,4AD2B@80864|Comamonadaceae 28216|Betaproteobacteria K PFAM response regulator receiver - - - ko:K02483 - - - - ko00000,ko02022 - - - Response_reg,Trans_reg_C k59_1367387_2 983920.Y88_0344 4.59e-30 118.0 COG0642@1|root,COG2205@2|Bacteria,1QTVU@1224|Proteobacteria,2TW3R@28211|Alphaproteobacteria,2K3UE@204457|Sphingomonadales 204457|Sphingomonadales T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c k59_180656_2 1209984.BN978_04916 9.33e-29 114.0 COG2071@1|root,COG2071@2|Bacteria,2GIV6@201174|Actinobacteria,234UX@1762|Mycobacteriaceae 201174|Actinobacteria S glutamine amidotransferase - - - ko:K07010 - - - - ko00000,ko01002 - - - Peptidase_C26 k59_1536659_1 548479.HMPREF0573_11290 5.37e-27 111.0 COG0286@1|root,COG0286@2|Bacteria,2GP6Y@201174|Actinobacteria,4D47V@85005|Actinomycetales 201174|Actinobacteria V N-6 DNA Methylase - - - - - - - - - - - - Methylase_S,N6_Mtase k59_1705751_1 1123354.AUDR01000015_gene261 2.66e-56 186.0 COG4105@1|root,COG4105@2|Bacteria,1MVS5@1224|Proteobacteria,2VH6I@28216|Betaproteobacteria,1KREX@119069|Hydrogenophilales 119069|Hydrogenophilales M Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane bamD - - ko:K05807 - - - - ko00000,ko02000 1.B.33.1 - - YfiO k59_236870_1 33876.JNXY01000035_gene679 2.14e-23 100.0 COG3154@1|root,COG3154@2|Bacteria,2INVN@201174|Actinobacteria,4DE1S@85008|Micromonosporales 201174|Actinobacteria I MDMPI C-terminal domain - - - - - - - - - - - - MDMPI_C,MDMPI_N k59_915019_1 323848.Nmul_A2384 6.69e-59 199.0 COG0062@1|root,COG0063@1|root,COG0062@2|Bacteria,COG0063@2|Bacteria,1MU1Q@1224|Proteobacteria,2VJZD@28216|Betaproteobacteria,371TF@32003|Nitrosomonadales 28216|Betaproteobacteria H Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration nnrD - 4.2.1.136 ko:K17758 - - - - ko00000,ko01000 - - - Carb_kinase,YjeF_N k59_180672_1 589924.Ferp_0317 1.64e-37 143.0 COG0458@1|root,arCOG01594@2157|Archaea,2XTVE@28890|Euryarchaeota,245PG@183980|Archaeoglobi 183980|Archaeoglobi F Belongs to the CarB family carB - 6.3.5.5 ko:K01955 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - - CPSase_L_D2,CPSase_L_D3,MGS k59_68324_1 247634.GPB2148_3150 3e-95 304.0 COG0013@1|root,COG0013@2|Bacteria,1MU9A@1224|Proteobacteria,1RMWZ@1236|Gammaproteobacteria,1J58G@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain alaS GO:0001130,GO:0001131,GO:0001141,GO:0001217,GO:0002161,GO:0002196,GO:0003674,GO:0003700,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006355,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006450,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009451,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016070,GO:0016597,GO:0016787,GO:0016788,GO:0016874,GO:0016875,GO:0019219,GO:0019222,GO:0019538,GO:0019752,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0042802,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045934,GO:0046483,GO:0046872,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0052689,GO:0060255,GO:0065007,GO:0065008,GO:0071704,GO:0080090,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:0140110,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141 6.1.1.7 ko:K01872 ko00970,map00970 M00359,M00360 R03038 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iECABU_c1320.ECABU_c29670,iECED1_1282.ECED1_3146,iEcHS_1320.EcHS_A2833,iJN746.PP_4474 DHHA1,tRNA-synt_2c,tRNA_SAD k59_802472_1 1122137.AQXF01000003_gene2481 2.34e-26 105.0 COG0668@1|root,COG0668@2|Bacteria,1MXD2@1224|Proteobacteria,2U2YT@28211|Alphaproteobacteria 28211|Alphaproteobacteria M Mechanosensitive ion channel - - - ko:K16052 - - - - ko00000,ko02000 1.A.23.4 - - MS_channel k59_802472_2 1122137.AQXF01000003_gene2480 8.71e-66 202.0 COG1607@1|root,COG1607@2|Bacteria,1MZAZ@1224|Proteobacteria,2U93J@28211|Alphaproteobacteria 28211|Alphaproteobacteria I Acyl-CoA hydrolase yciA - - ko:K10806 ko01040,map01040 - - - ko00000,ko00001,ko01000,ko01004 - - - 4HBT k59_1762486_1 1229909.NSED_08975 3.23e-66 207.0 arCOG10598@1|root,arCOG10598@2157|Archaea 2157|Archaea S ATP-dependent protease La (LON) substrate-binding domain - - - ko:K07157 - - - - ko00000 - - - LON_substr_bdg k59_1140950_1 710696.Intca_0464 2.39e-09 63.2 COG1502@1|root,COG1502@2|Bacteria,2GN2V@201174|Actinobacteria,4FE9K@85021|Intrasporangiaceae 201174|Actinobacteria I Phospholipase D. Active site motifs. - - - - - - - - - - - - PLDc,PLDc_2 k59_1140950_2 1121272.KB903289_gene4129 5.46e-05 45.1 2DBMZ@1|root,2ZA12@2|Bacteria,2IIKK@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - - k59_1367427_1 745411.B3C1_05025 1.42e-13 68.6 COG1286@1|root,COG1286@2|Bacteria,1NF4G@1224|Proteobacteria,1RQ58@1236|Gammaproteobacteria,1J6GJ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S membrane protein, required for colicin V production cvpA GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008152,GO:0009058,GO:0009403,GO:0009404,GO:0009987,GO:0016020,GO:0019748,GO:0044237,GO:0044249,GO:0044464,GO:0044550,GO:0071944 - ko:K03558 - - - - ko00000 - - - Colicin_V k59_1367427_2 1209072.ALBT01000052_gene585 9.36e-17 78.6 COG3147@1|root,COG3147@2|Bacteria,1NGE3@1224|Proteobacteria,1SCGC@1236|Gammaproteobacteria,1FHC3@10|Cellvibrio 1236|Gammaproteobacteria S Sporulation related domain dedD - - ko:K03749 - - - - ko00000 - - - SPOR k59_576044_1 941824.TCEL_00423 5.82e-19 88.2 COG1028@1|root,COG1028@2|Bacteria,1TR1J@1239|Firmicutes,248AA@186801|Clostridia,36I5Y@31979|Clostridiaceae 186801|Clostridia IQ Enoyl-(Acyl carrier protein) reductase - - - - - - - - - - - - adh_short_C2 k59_576044_2 1207055.C100_16875 1.15e-32 125.0 COG0477@1|root,COG2814@2|Bacteria,1R7DW@1224|Proteobacteria,2U4H7@28211|Alphaproteobacteria,2KCE8@204457|Sphingomonadales 204457|Sphingomonadales EGP Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 k59_180693_1 1207063.P24_03156 1.47e-63 210.0 COG2114@1|root,COG2114@2|Bacteria,1MV1V@1224|Proteobacteria,2TRUC@28211|Alphaproteobacteria,2JQP6@204441|Rhodospirillales 204441|Rhodospirillales T COG2114 Adenylate cyclase, family 3 (some proteins contain HAMP domain) - - 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 - - - Guanylate_cyc k59_350650_1 330214.NIDE4257 1.5e-129 377.0 COG2084@1|root,COG2084@2|Bacteria,3J0R5@40117|Nitrospirae 40117|Nitrospirae I NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase - - 1.1.1.31 ko:K00020 ko00280,ko01100,map00280,map01100 - R05066 RC00099 ko00000,ko00001,ko01000 - - - NAD_binding_11,NAD_binding_2 k59_1423290_1 1088721.NSU_2708 3.31e-124 361.0 COG2197@1|root,COG2197@2|Bacteria,1QWED@1224|Proteobacteria,2TWX4@28211|Alphaproteobacteria,2K3JN@204457|Sphingomonadales 204457|Sphingomonadales KT Taurine catabolism dioxygenase TauD, TfdA - - - - - - - - - - - - TauD k59_802494_1 1122137.AQXF01000009_gene12 4.1e-136 421.0 COG0086@1|root,COG0086@2|Bacteria,1MU3M@1224|Proteobacteria,2TRHV@28211|Alphaproteobacteria 28211|Alphaproteobacteria K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoC GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234 2.7.7.6 ko:K03046,ko:K13797 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5 k59_1310881_1 1230343.CANP01000007_gene604 6.81e-13 73.2 COG2863@1|root,COG2863@2|Bacteria,1N2NB@1224|Proteobacteria,1RZFP@1236|Gammaproteobacteria,1JE46@118969|Legionellales 118969|Legionellales C Cytochrome c cyc4 - - - - - - - - - - - Cytochrom_C k59_350665_1 751994.AGIG01000027_gene1433 2.78e-39 137.0 COG0454@1|root,COG0456@2|Bacteria,1RJ1K@1224|Proteobacteria,1S6RV@1236|Gammaproteobacteria 1236|Gammaproteobacteria K PFAM GCN5-related N-acetyltransferase - - - - - - - - - - - - Acetyltransf_1 k59_180711_1 56110.Oscil6304_3511 8.84e-63 214.0 COG5001@1|root,COG5001@2|Bacteria,1G0SY@1117|Cyanobacteria,1H7TU@1150|Oscillatoriales 1117|Cyanobacteria T COGs COG5001 signal transduction protein containing a membrane domain an EAL and a GGDEF domain - - - - - - - - - - - - EAL,GGDEF,Response_reg k59_1423299_1 1549858.MC45_02230 1.11e-74 246.0 COG1629@1|root,COG4206@1|root,COG1629@2|Bacteria,COG4206@2|Bacteria,1QU0R@1224|Proteobacteria,2TTAI@28211|Alphaproteobacteria,2JZX1@204457|Sphingomonadales 204457|Sphingomonadales HP TonB dependent receptor - - - - - - - - - - - - Plug,TonB_dep_Rec k59_859338_1 1278073.MYSTI_06609 1.7e-30 111.0 COG3436@1|root,COG3436@2|Bacteria,1RHDW@1224|Proteobacteria,43BFC@68525|delta/epsilon subdivisions,2X6TQ@28221|Deltaproteobacteria 28221|Deltaproteobacteria L IS66 Orf2 like protein - - - ko:K07484 - - - - ko00000 - - - TnpB_IS66 k59_1310893_1 545276.KB898727_gene541 1.2e-38 143.0 COG1565@1|root,COG1565@2|Bacteria,1N3CJ@1224|Proteobacteria,1RYCJ@1236|Gammaproteobacteria,1WWJG@135613|Chromatiales 135613|Chromatiales S Putative S-adenosyl-L-methionine-dependent methyltransferase - - - - - - - - - - - - Methyltransf_28 k59_236909_1 1265313.HRUBRA_02804 2.34e-126 368.0 COG0208@1|root,COG0208@2|Bacteria,1R4T3@1224|Proteobacteria,1S1Y5@1236|Gammaproteobacteria 1236|Gammaproteobacteria F P-aminobenzoate N-oxygenase AurF - - - - - - - - - - - - AurF k59_859339_1 1123503.KB908057_gene2403 5.82e-29 117.0 COG3182@1|root,COG3182@2|Bacteria,1MX8C@1224|Proteobacteria,2TSQ9@28211|Alphaproteobacteria,2KGI5@204458|Caulobacterales 204458|Caulobacterales S PepSY-associated TM region - - - - - - - - - - - - PepSY_TM k59_859339_2 1122194.AUHU01000015_gene3042 1.27e-14 73.9 COG1629@1|root,COG4771@2|Bacteria,1MXSN@1224|Proteobacteria,1RZC0@1236|Gammaproteobacteria,469HA@72275|Alteromonadaceae 1236|Gammaproteobacteria P TonB dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_576078_1 316407.85675973 9.84e-125 356.0 COG0293@1|root,COG0293@2|Bacteria,1MW1C@1224|Proteobacteria,1RN5M@1236|Gammaproteobacteria,3XP2N@561|Escherichia 1236|Gammaproteobacteria J Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit ftsJ GO:0000027,GO:0000154,GO:0000451,GO:0000453,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008173,GO:0008649,GO:0008650,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016072,GO:0016436,GO:0016740,GO:0016741,GO:0022607,GO:0022613,GO:0022618,GO:0031167,GO:0032259,GO:0034470,GO:0034622,GO:0034641,GO:0034660,GO:0042254,GO:0042255,GO:0042273,GO:0043170,GO:0043412,GO:0043414,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.166 ko:K02427 - - - - ko00000,ko01000,ko03009 - - - FtsJ k59_576079_1 1265313.HRUBRA_02126 1.63e-78 255.0 COG4774@1|root,COG4774@2|Bacteria,1RBVQ@1224|Proteobacteria,1SMVM@1236|Gammaproteobacteria,1J8EM@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P TonB-dependent Receptor Plug Domain - - - - - - - - - - - - Plug k59_294235_1 1122137.AQXF01000006_gene862 5.7e-158 450.0 COG0454@1|root,COG0456@2|Bacteria,1PMA3@1224|Proteobacteria,2TUU2@28211|Alphaproteobacteria 28211|Alphaproteobacteria K acetyltransferase - - - - - - - - - - - - - k59_971095_1 1122137.AQXF01000002_gene506 2.47e-58 196.0 COG1960@1|root,COG1960@2|Bacteria,1MU20@1224|Proteobacteria,2TQJS@28211|Alphaproteobacteria 28211|Alphaproteobacteria I acyl-CoA dehydrogenase mmgC GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016627,GO:0036094,GO:0043167,GO:0043168,GO:0048037,GO:0050660,GO:0050662,GO:0052890,GO:0055114,GO:0097159,GO:1901265,GO:1901363 1.3.8.1,1.3.8.7 ko:K00248,ko:K00249,ko:K20035 ko00071,ko00280,ko00410,ko00640,ko00650,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map00650,map00920,map01100,map01110,map01120,map01130,map01200,map01212,map03320 M00013,M00036,M00087 R00924,R01175,R01178,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754,R11130 RC00052,RC00068,RC00076,RC00095,RC00120,RC00148,RC00246,RC03363 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_C,Acyl-CoA_dh_M,Acyl-CoA_dh_N,AcylCoA_DH_N k59_11659_2 509190.Cseg_0448 2.44e-44 147.0 COG3727@1|root,COG3727@2|Bacteria,1RH1C@1224|Proteobacteria,2UA6G@28211|Alphaproteobacteria,2KGWM@204458|Caulobacterales 204458|Caulobacterales L May nick specific sequences that contain T G mispairs resulting from m5C-deamination - - - ko:K07458 - - - - ko00000,ko01000,ko03400 - - - Vsr k59_124552_1 591158.SSMG_03168 5.42e-34 134.0 COG1020@1|root,COG1020@2|Bacteria,2GISR@201174|Actinobacteria 201174|Actinobacteria Q Non-ribosomal peptide synthetase modules and related proteins - - - - - - - - - - - - AMP-binding,AMP-binding_C,Beta-lactamase,Condensation,PP-binding,Thioesterase k59_1029122_1 857087.Metme_0930 2.48e-66 214.0 COG3178@1|root,COG3178@2|Bacteria,1MXCH@1224|Proteobacteria,1RQ1Q@1236|Gammaproteobacteria,1XDY9@135618|Methylococcales 135618|Methylococcales S Phosphotransferase enzyme family - - 2.7.1.221 ko:K07102 ko00520,ko01100,map00520,map01100 - R08968,R11024 RC00002,RC00078 ko00000,ko00001,ko01000 - - - APH k59_236929_1 1246995.AFR_40305 1.54e-23 103.0 COG0477@1|root,COG2814@2|Bacteria,2GJU2@201174|Actinobacteria,4D9HH@85008|Micromonosporales 201174|Actinobacteria EGP Major facilitator superfamily - - - - - - - - - - - - MFS_1,Sugar_tr k59_124556_1 1121022.ABENE_21490 1.52e-75 243.0 COG2303@1|root,COG2303@2|Bacteria,1MU3F@1224|Proteobacteria,2TT3C@28211|Alphaproteobacteria,2KFW2@204458|Caulobacterales 204458|Caulobacterales E Oxidoreductase - - - - - - - - - - - - GMC_oxred_C,GMC_oxred_N k59_1197696_1 1127673.GLIP_2758 1.82e-14 78.2 COG2182@1|root,COG2182@2|Bacteria,1MU3H@1224|Proteobacteria,1RY48@1236|Gammaproteobacteria,464R5@72275|Alteromonadaceae 1236|Gammaproteobacteria G Parallel beta-helix repeats - - - - - - - - - - - - - k59_859375_1 1144305.PMI02_03424 7.96e-123 363.0 COG2159@1|root,COG2159@2|Bacteria,1R4UN@1224|Proteobacteria,2U2QQ@28211|Alphaproteobacteria,2K96D@204457|Sphingomonadales 204457|Sphingomonadales S Amidohydrolase - - - - - - - - - - - - Amidohydro_2 k59_1029126_1 1128912.GMES_0254 2.03e-09 61.6 COG0428@1|root,COG0428@2|Bacteria,1N3QA@1224|Proteobacteria,1RR8U@1236|Gammaproteobacteria,466K5@72275|Alteromonadaceae 1236|Gammaproteobacteria P divalent heavy-metal cations transporter - - - ko:K07238 - - - - ko00000,ko02000 2.A.5.5 - - Zip k59_124563_1 1041159.AZUW01000033_gene2462 2.69e-29 120.0 COG1529@1|root,COG1529@2|Bacteria,1QTTJ@1224|Proteobacteria,2TQVK@28211|Alphaproteobacteria,4B9W8@82115|Rhizobiaceae 28211|Alphaproteobacteria C Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain MA20_17495 - 1.3.99.16 ko:K07303 - - - - ko00000,ko01000 - - - Ald_Xan_dh_C2 k59_1592973_1 1229909.NSED_03430 2.74e-153 448.0 COG0155@1|root,arCOG02055@2157|Archaea,41S5Q@651137|Thaumarchaeota 651137|Thaumarchaeota C Sulfite reductase - - 1.8.7.1 ko:K00392 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00176 R00859,R03600 RC00065 ko00000,ko00001,ko00002,ko01000 - - - NIR_SIR,NIR_SIR_ferr k59_1592973_2 1229909.NSED_03425 2.75e-66 208.0 COG2897@1|root,arCOG02019@2157|Archaea,41SBN@651137|Thaumarchaeota 651137|Thaumarchaeota P Rhodanese Homology Domain - - 2.8.1.1,2.8.1.2 ko:K01011 ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122 - R01931,R03105,R03106 RC00214 ko00000,ko00001,ko01000 - - - Rhodanese k59_1254339_1 1121456.ATVA01000011_gene1419 7.47e-98 317.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJVV@28221|Deltaproteobacteria,2M817@213115|Desulfovibrionales 28221|Deltaproteobacteria V TIGRFAM transporter, hydrophobe amphiphile efflux-1 (HAE1) family - - - ko:K03296,ko:K18138 ko01501,ko01503,map01501,map01503 M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000 2.A.6.2 - - ACR_tran k59_859385_1 1121448.DGI_2712 8.8e-45 166.0 COG0642@1|root,COG1352@1|root,COG2201@1|root,COG0642@2|Bacteria,COG1352@2|Bacteria,COG2201@2|Bacteria,1NXDJ@1224|Proteobacteria,43BMJ@68525|delta/epsilon subdivisions,2WUEV@28221|Deltaproteobacteria,2MH9E@213115|Desulfovibrionales 28221|Deltaproteobacteria T response regulator, receiver - - 2.1.1.80,3.1.1.61 ko:K13924 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko02022,ko02035 - - - CheB_methylest,CheR,CheR_N,HATPase_c,HisKA,PAS_4,Response_reg k59_859386_1 1121403.AUCV01000004_gene2065 5.39e-94 287.0 COG0161@1|root,COG0161@2|Bacteria,1MU2N@1224|Proteobacteria,42MFC@68525|delta/epsilon subdivisions,2WJ4H@28221|Deltaproteobacteria,2MICW@213118|Desulfobacterales 28221|Deltaproteobacteria H Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor bioA - 2.6.1.62 ko:K00833 ko00780,ko01100,map00780,map01100 M00123,M00573,M00577 R03231 RC00006,RC00887 ko00000,ko00001,ko00002,ko01000,ko01007 - - - AAA_26,Aminotran_3 k59_923654_1 545276.KB898724_gene1820 4.41e-29 111.0 COG0623@1|root,COG0623@2|Bacteria,1MV05@1224|Proteobacteria,1RNMW@1236|Gammaproteobacteria,1WX1J@135613|Chromatiales 135613|Chromatiales I Enoyl- acyl-carrier-protein reductase NADH - - 1.3.1.10,1.3.1.9 ko:K00208 ko00061,ko00333,ko00780,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01100,map01130,map01212 M00083,M00572 R01404,R04429,R04430,R04724,R04725,R04955,R04956,R04958,R04959,R04961,R04962,R04966,R04967,R04969,R04970,R07765,R10118,R10122,R11671 RC00052,RC00076,RC00120 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 k59_1149366_1 1346330.M472_08690 7.88e-17 85.1 COG0526@1|root,COG0526@2|Bacteria,4NNY5@976|Bacteroidetes,1IT32@117747|Sphingobacteriia 976|Bacteroidetes CO COG0526 Thiol-disulfide isomerase and thioredoxins - - - - - - - - - - - - AhpC-TSA,DUF4369,Thioredoxin_8 k59_641123_1 1380391.JIAS01000019_gene1161 4.88e-50 164.0 COG3793@1|root,COG3793@2|Bacteria,1RD1X@1224|Proteobacteria,2U788@28211|Alphaproteobacteria,2JTSP@204441|Rhodospirillales 204441|Rhodospirillales P Tellurite resistance protein TerB - - - - - - - - - - - - TerB k59_1092905_1 331869.BAL199_30557 5.74e-92 283.0 COG3666@1|root,COG3666@2|Bacteria,1N3QR@1224|Proteobacteria,2U4DT@28211|Alphaproteobacteria 28211|Alphaproteobacteria L COG3666 Transposase and inactivated derivatives - - - - - - - - - - - - DDE_Tnp_1,DDE_Tnp_1_6,DUF772 k59_1150510_2 309807.SRU_0388 3.95e-41 141.0 2AZF8@1|root,31RP4@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_1039019_1 1042163.BRLA_c039920 0.000308 49.3 COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,1TR2N@1239|Firmicutes,4H9RR@91061|Bacilli,26VDG@186822|Paenibacillaceae 91061|Bacilli EU COG1506 Dipeptidyl aminopeptidases acylaminoacyl-peptidases yuxL - 3.4.19.1 ko:K01303 - - - - ko00000,ko01000,ko01002 - - - PD40,Peptidase_S9 k59_246613_1 1206730.BAGA01000171_gene2189 4.19e-88 275.0 COG1012@1|root,COG1012@2|Bacteria,2GIWZ@201174|Actinobacteria,4FVYU@85025|Nocardiaceae 201174|Actinobacteria C Belongs to the aldehyde dehydrogenase family - - 1.2.1.3 ko:K00128 ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130 M00135 R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146 RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_1546770_1 1348338.ADILRU_0593 9.28e-47 158.0 COG3638@1|root,COG3638@2|Bacteria,2GK02@201174|Actinobacteria,4FKWP@85023|Microbacteriaceae 201174|Actinobacteria P Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system phnC - 3.6.3.28 ko:K02041 ko02010,map02010 M00223 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.9 - - ABC_tran k59_1207412_1 1122137.AQXF01000003_gene2033 3.37e-21 94.7 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,2TQR7@28211|Alphaproteobacteria 28211|Alphaproteobacteria T methyl-accepting chemotaxis protein - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - MCPsignal,PAS_3,PAS_4,PAS_9 k59_360750_1 1414720.CBYM010000007_gene1174 5.07e-35 137.0 COG1472@1|root,COG1472@2|Bacteria,1TP0T@1239|Firmicutes,24932@186801|Clostridia,36EVW@31979|Clostridiaceae 186801|Clostridia G hydrolase, family 3 - - 3.2.1.21 ko:K05349 ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110 - R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040 RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248 ko00000,ko00001,ko01000 - GH3 - Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C k59_1432633_1 1121912.AUHD01000001_gene2337 1.03e-52 176.0 28IMZ@1|root,2Z8NF@2|Bacteria,4NIZ8@976|Bacteroidetes,1I0D0@117743|Flavobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - CarbopepD_reg_2 k59_980041_1 1123057.P872_08485 6.01e-41 156.0 COG2091@1|root,COG2091@2|Bacteria,4NFQ6@976|Bacteroidetes,47MUU@768503|Cytophagia 976|Bacteroidetes H Carbohydrate family 9 binding domain-like - - - - - - - - - - - - CBM9_1 k59_980041_2 452637.Oter_0067 6.53e-09 57.4 COG3279@1|root,COG3279@2|Bacteria,46VCX@74201|Verrucomicrobia,3KA2E@414999|Opitutae 2|Bacteria K PFAM response regulator receiver - - - ko:K02477 - - - - ko00000,ko02022 - - - EAL,HATPase_c,HisKA,LytTR,Response_reg k59_1490553_1 312309.VF_2278 5.96e-32 122.0 COG1220@1|root,COG1220@2|Bacteria,1MVK9@1224|Proteobacteria,1RMYV@1236|Gammaproteobacteria,1XSGN@135623|Vibrionales 135623|Vibrionales O this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis hslU GO:0003674,GO:0003824,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0016787,GO:0019538,GO:0043170,GO:0044238,GO:0071704,GO:0140096,GO:1901564 - ko:K03667 - - - - ko00000,ko03110 - - - AAA_2,ClpB_D2-small k59_1490553_2 93220.LV28_18280 1.12e-38 134.0 COG3536@1|root,COG3536@2|Bacteria,1MZ5M@1224|Proteobacteria,2VR9K@28216|Betaproteobacteria,1K72E@119060|Burkholderiaceae 28216|Betaproteobacteria S Protein of unknown function (DUF971) - - - - - - - - - - - - DUF971 k59_1490555_1 1144305.PMI02_01715 1.92e-53 178.0 COG1028@1|root,COG1028@2|Bacteria,1MVKN@1224|Proteobacteria,2U301@28211|Alphaproteobacteria,2K0TY@204457|Sphingomonadales 204457|Sphingomonadales IQ short-chain dehydrogenase - - - - - - - - - - - - adh_short k59_1490555_2 1172185.KB911512_gene5041 2.58e-29 110.0 COG5517@1|root,COG5517@2|Bacteria,2GR5G@201174|Actinobacteria,4G0XR@85025|Nocardiaceae 201174|Actinobacteria Q SnoaL-like domain - - - - - - - - - - - - SnoaL_4 k59_1546812_1 279238.Saro_0895 2.71e-103 321.0 COG4773@1|root,COG4773@2|Bacteria,1QTXJ@1224|Proteobacteria,2UKU2@28211|Alphaproteobacteria,2K9NF@204457|Sphingomonadales 204457|Sphingomonadales P TonB dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_1432652_1 1122137.AQXF01000005_gene1044 2.51e-51 184.0 COG1629@1|root,COG1629@2|Bacteria,1MWTT@1224|Proteobacteria,2TURM@28211|Alphaproteobacteria 28211|Alphaproteobacteria P receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - OMP_b-brl_3,Plug,TonB_dep_Rec k59_1490560_2 436308.Nmar_1467 4.94e-40 144.0 COG1525@1|root,arCOG03192@2157|Archaea 2157|Archaea L COG1525 Micrococcal nuclease (thermonuclease) homologs - - 3.1.31.1 ko:K01174 - - - - ko00000,ko01000 - - - SNase k59_1659664_1 1120950.KB892826_gene649 2.24e-07 57.8 COG1132@1|root,COG1132@2|Bacteria,2GJYK@201174|Actinobacteria,4DT7S@85009|Propionibacteriales 201174|Actinobacteria V ABC transporter - - - ko:K06147 - - - - ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_tran k59_698929_1 1266925.JHVX01000003_gene381 1.22e-91 285.0 COG0260@1|root,COG0260@2|Bacteria,1MUF9@1224|Proteobacteria,2VH79@28216|Betaproteobacteria,372AV@32003|Nitrosomonadales 28216|Betaproteobacteria E Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides pepA GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0016787,GO:0019538,GO:0019904,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0097718,GO:0140096,GO:1901564 3.4.11.1 ko:K01255 ko00480,ko01100,map00480,map01100 - R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 - - - Peptidase_M17,Peptidase_M17_N k59_416190_1 83406.HDN1F_15760 5.8e-28 110.0 COG2834@1|root,COG2834@2|Bacteria,1PXDV@1224|Proteobacteria,1S9FW@1236|Gammaproteobacteria,1J6XQ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) lolA GO:0002790,GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0006810,GO:0008104,GO:0008150,GO:0008565,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0030288,GO:0030313,GO:0031975,GO:0032940,GO:0033036,GO:0034613,GO:0042597,GO:0042886,GO:0042953,GO:0042954,GO:0044464,GO:0044872,GO:0044873,GO:0044874,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0051641,GO:0070727,GO:0071702,GO:0071705,GO:0072321,GO:0072322,GO:0072323,GO:0072657 - ko:K03634 - - - - ko00000 - - - LolA k59_1432653_2 1306990.BARG01000033_gene3741 5.15e-17 75.9 COG4405@1|root,COG4405@2|Bacteria,2IFEU@201174|Actinobacteria 201174|Actinobacteria S F420H(2)-dependent quinone reductase - - - - - - - - - - - - F420H2_quin_red k59_811926_1 404589.Anae109_4389 8.18e-80 259.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,2YU4M@29|Myxococcales 28221|Deltaproteobacteria T Bacterial regulatory protein, Fis family sasR - - ko:K07713 ko02020,map02020 M00499 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_1377489_1 224911.27354913 1.24e-17 80.1 28MZJ@1|root,2ZB69@2|Bacteria,1R6VF@1224|Proteobacteria,2U26P@28211|Alphaproteobacteria,3JR7G@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria - - MA20_01630 - - - - - - - - - - - - k59_1377489_2 1122604.JONR01000035_gene355 1.82e-22 95.9 COG0688@1|root,COG0688@2|Bacteria,1MVT4@1224|Proteobacteria,1RN1U@1236|Gammaproteobacteria,1X3VJ@135614|Xanthomonadales 1236|Gammaproteobacteria I Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer) - - 4.1.1.65 ko:K01613 ko00564,ko01100,ko01110,map00564,map01100,map01110 M00093 R02055 RC00299 ko00000,ko00001,ko00002,ko01000 - - - PS_Dcarbxylase k59_360792_1 1151127.KB906325_gene5450 1.43e-90 292.0 COG0607@1|root,COG0626@1|root,COG2897@1|root,COG0607@2|Bacteria,COG0626@2|Bacteria,COG2897@2|Bacteria,1MU9E@1224|Proteobacteria,1RQI0@1236|Gammaproteobacteria,1YS3J@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria EP Cys/Met metabolism PLP-dependent enzyme - - 4.4.1.8 ko:K01760 ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230 M00017 R00782,R01286,R02408,R04941 RC00056,RC00069,RC00382,RC00488,RC00710,RC01245,RC02303 ko00000,ko00001,ko00002,ko01000 - - - Cys_Met_Meta_PP,Rhodanese k59_1207455_1 592029.DDD_3011 6.55e-09 61.2 COG2203@1|root,COG2203@2|Bacteria,4NE84@976|Bacteroidetes,1HXM4@117743|Flavobacteriia,3HJ5Z@363408|Nonlabens 976|Bacteroidetes T Gaf domain - - - - - - - - - - - - - k59_1546835_1 1122194.AUHU01000005_gene945 3.96e-112 330.0 COG0016@1|root,COG0016@2|Bacteria,1MVD7@1224|Proteobacteria,1RN22@1236|Gammaproteobacteria,465BM@72275|Alteromonadaceae 1236|Gammaproteobacteria J Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily pheS GO:0003674,GO:0003824,GO:0004812,GO:0004826,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.20 ko:K01889 ko00970,map00970 M00359,M00360 R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iJN746.PP_2469 Phe_tRNA-synt_N,tRNA-synt_2d k59_190608_1 1415778.JQMM01000001_gene709 1.43e-47 167.0 COG2813@1|root,COG2813@2|Bacteria,1MXE9@1224|Proteobacteria,1RQCH@1236|Gammaproteobacteria,1J64R@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle rsmC GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0008990,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0052914,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.172 ko:K00564 - - R07234 RC00003 ko00000,ko01000,ko03009 - - - MTS,MTS_N k59_1263054_2 506534.Rhein_2686 1.14e-21 92.0 COG0784@1|root,COG0835@1|root,COG0784@2|Bacteria,COG0835@2|Bacteria,1N81M@1224|Proteobacteria,1RPS1@1236|Gammaproteobacteria,1WX9N@135613|Chromatiales 135613|Chromatiales T response regulator receiver - - - ko:K03415 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko02022,ko02035 - - - CheW,Response_reg k59_924593_1 485913.Krac_4715 2.18e-29 120.0 COG2272@1|root,COG2272@2|Bacteria 2|Bacteria I carboxylic ester hydrolase activity - - - ko:K03929 - - - - ko00000,ko01000 - CE10 - COesterase k59_78599_1 745310.G432_00055 4.93e-20 89.7 COG0477@1|root,COG2814@2|Bacteria,1MW59@1224|Proteobacteria,2TRA3@28211|Alphaproteobacteria,2K41Z@204457|Sphingomonadales 204457|Sphingomonadales EGP Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 k59_78599_2 1297865.APJD01000020_gene64 4.29e-06 48.5 COG3808@1|root,COG3808@2|Bacteria,1MUQ3@1224|Proteobacteria,2TR9G@28211|Alphaproteobacteria,3JUCV@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria C Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force hppA - 3.6.1.1 ko:K15987 ko00190,map00190 - - - ko00000,ko00001,ko01000 3.A.10.1 - - H_PPase k59_1150591_1 1229909.NSED_07460 8.83e-125 363.0 COG0330@1|root,arCOG01915@2157|Archaea,41SYP@651137|Thaumarchaeota 651137|Thaumarchaeota O PFAM SPFH domain Band 7 family - - - - - - - - - - - - Band_7 k59_811940_1 1229909.NSED_03230 5.69e-24 100.0 arCOG08742@1|root,arCOG08742@2157|Archaea,41SS8@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_811940_2 436308.Nmar_0626 1.67e-29 112.0 COG0391@1|root,arCOG04395@2157|Archaea,41SCH@651137|Thaumarchaeota 651137|Thaumarchaeota H Uncharacterised protein family UPF0052 - - 2.7.8.28 ko:K11212 ko00680,ko01120,map00680,map01120 M00378 R09398 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - UPF0052 k59_78610_1 28229.ND2E_2388 2.54e-46 153.0 COG0450@1|root,COG0450@2|Bacteria,1MWPY@1224|Proteobacteria,1RN4S@1236|Gammaproteobacteria,2Q6F4@267889|Colwelliaceae 1236|Gammaproteobacteria O C-terminal domain of 1-Cys peroxiredoxin tsaA - 1.11.1.15 ko:K03386 ko04214,map04214 - - - ko00000,ko00001,ko01000,ko04147 - - - 1-cysPrx_C,AhpC-TSA k59_416221_1 414684.RC1_2227 2.03e-47 174.0 COG4784@1|root,COG4784@2|Bacteria,1QTT7@1224|Proteobacteria,2TTU7@28211|Alphaproteobacteria,2JQHE@204441|Rhodospirillales 204441|Rhodospirillales S Peptidase family M48 - - - - - - - - - - - - LysM,Peptidase_M48 k59_134185_1 1121935.AQXX01000139_gene3042 5.75e-117 355.0 COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,1RR14@1236|Gammaproteobacteria,1XIX7@135619|Oceanospirillales 135619|Oceanospirillales I COG0365 Acyl-coenzyme A synthetases AMP-(fatty) acid ligases prpE - 6.2.1.17 ko:K01908 ko00640,ko01100,map00640,map01100 - R00926,R01354 RC00004,RC00043,RC00070,RC02816 ko00000,ko00001,ko01000,ko01004 - - - ACAS_N,AMP-binding,AMP-binding_C k59_1602991_1 247634.GPB2148_3541 2.85e-65 229.0 COG1629@1|root,COG4771@2|Bacteria,1MWKN@1224|Proteobacteria,1SJX0@1236|Gammaproteobacteria,1J8GZ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P COG1629 Outer membrane receptor proteins, mostly Fe transport - - - - - - - - - - - - Plug,TonB_dep_Rec k59_698974_1 1144305.PMI02_03840 1.1e-109 327.0 COG0044@1|root,COG0044@2|Bacteria,1MW10@1224|Proteobacteria,2TSQH@28211|Alphaproteobacteria,2K0G9@204457|Sphingomonadales 204457|Sphingomonadales F Catalyzes the reversible hydrolysis of the amide bond within dihydroorotate. This metabolic intermediate is required for the biosynthesis of pyrimidine nucleotides - - 3.5.2.3 ko:K01465 ko00240,ko01100,map00240,map01100 M00051 R01993 RC00632 ko00000,ko00001,ko00002,ko01000 - - - Amidohydro_1 k59_980084_1 996637.SGM_6605 5.02e-48 168.0 COG0415@1|root,COG0415@2|Bacteria,2GJXU@201174|Actinobacteria 201174|Actinobacteria L Belongs to the DNA photolyase family phr - 4.1.99.3 ko:K01669 - - - - ko00000,ko01000,ko03400 - - - DNA_photolyase,FAD_binding_7 k59_980084_2 1463820.JOGW01000001_gene5598 1.36e-32 119.0 COG0346@1|root,COG0346@2|Bacteria,2IKKR@201174|Actinobacteria 201174|Actinobacteria E glyoxalase bleomycin resistance protein dioxygenase - - - - - - - - - - - - Glyoxalase k59_980084_3 864702.OsccyDRAFT_2934 1.49e-53 189.0 COG2114@1|root,COG2202@1|root,COG2203@1|root,COG3850@1|root,COG2114@2|Bacteria,COG2202@2|Bacteria,COG2203@2|Bacteria,COG3850@2|Bacteria,1FZXP@1117|Cyanobacteria,1H71W@1150|Oscillatoriales 1117|Cyanobacteria T Belongs to the adenylyl cyclase class-4 guanylyl cyclase family - - 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 - - - GAF,Guanylate_cyc,HAMP,PAS,PAS_4,PAS_9,dCache_1 k59_1546882_1 443144.GM21_1063 1.74e-43 158.0 COG3005@1|root,COG3005@2|Bacteria,1R956@1224|Proteobacteria,42Q0X@68525|delta/epsilon subdivisions,2WMHI@28221|Deltaproteobacteria,43U0A@69541|Desulfuromonadales 28221|Deltaproteobacteria C NapC/NirT cytochrome c family, N-terminal region - GO:0003674,GO:0003824,GO:0005575,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0022900,GO:0031224,GO:0044237,GO:0044425,GO:0045333,GO:0055114 - - - - - - - - - - Cytochrom_NNT k59_472440_1 1007105.PT7_0805 7.79e-92 281.0 COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,2VHJP@28216|Betaproteobacteria,3T1SD@506|Alcaligenaceae 28216|Betaproteobacteria G C4-dicarboxylate ABC transporter permease - - - ko:K11690 ko02020,map02020 - - - ko00000,ko00001,ko02000 2.A.56.1 - - DctM k59_134206_1 1125863.JAFN01000001_gene353 1.45e-97 311.0 COG0458@1|root,COG0458@2|Bacteria,1MUDZ@1224|Proteobacteria,42MGK@68525|delta/epsilon subdivisions,2WJQH@28221|Deltaproteobacteria 28221|Deltaproteobacteria F Belongs to the CarB family carB - 6.3.5.5 ko:K01955 ko00240,ko00250,ko01100,map00240,map00250,map01100 M00051 R00256,R00575,R01395,R10948,R10949 RC00002,RC00010,RC00043,RC02750,RC02798,RC03314 ko00000,ko00001,ko00002,ko01000 - - - CPSase_L_D2,CPSase_L_D3,MGS k59_754899_1 583345.Mmol_2147 5.81e-80 258.0 COG4796@1|root,COG4796@2|Bacteria,1QTT6@1224|Proteobacteria,2VHY4@28216|Betaproteobacteria,2KKNT@206350|Nitrosomonadales 206350|Nitrosomonadales U type II and III secretion system protein - - - ko:K02666 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - AMIN,STN,Secretin,Secretin_N k59_1715839_1 1122137.AQXF01000001_gene3359 2.48e-174 503.0 COG1022@1|root,COG1022@2|Bacteria,1MU4D@1224|Proteobacteria,2TSSI@28211|Alphaproteobacteria 28211|Alphaproteobacteria I COG1022 Long-chain acyl-CoA synthetases (AMP-forming) - - 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding k59_1715839_2 1250232.JQNJ01000001_gene164 4.06e-20 90.9 COG3023@1|root,COG3023@2|Bacteria,4PKIH@976|Bacteroidetes,1IJA2@117743|Flavobacteriia 976|Bacteroidetes V Alpha-glucosidase - - 3.2.1.20,3.2.1.3 ko:K01187,ko:K21574 ko00052,ko00500,ko01100,map00052,map00500,map01100 - R00028,R00801,R00802,R01790,R01791,R06087,R06088 RC00028,RC00049,RC00077 ko00000,ko00001,ko01000 - GH31,GH97 - GH97_C,GH97_N,Glyco_hydro_97 k59_1432707_1 570952.ATVH01000011_gene359 1.78e-87 268.0 28W6R@1|root,2ZI7D@2|Bacteria,1N49N@1224|Proteobacteria,2UQMC@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_472446_2 760568.Desku_0762 9.95e-15 77.0 COG0863@1|root,COG0863@2|Bacteria,1TRDZ@1239|Firmicutes,249ZT@186801|Clostridia,2652N@186807|Peptococcaceae 186801|Clostridia H DNA methylase - - 2.1.1.72 ko:K00571 - - - - ko00000,ko01000,ko02048 - - - N6_N4_Mtase k59_980102_1 298654.FraEuI1c_6408 6.18e-18 87.0 COG2755@1|root,COG2755@2|Bacteria,2GRDF@201174|Actinobacteria,4EV2Y@85013|Frankiales 201174|Actinobacteria E GDSL-like Lipase/Acylhydrolase family - - - - - - - - - - - - Lipase_GDSL_2 k59_1546906_1 666681.M301_1373 3.68e-44 163.0 COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,2VHSK@28216|Betaproteobacteria,2KMDN@206350|Nitrosomonadales 206350|Nitrosomonadales KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance - - 2.7.6.5 ko:K00951 ko00230,map00230 - R00429 RC00002,RC00078 ko00000,ko00001,ko01000 - - - ACT_4,HD_4,RelA_SpoT,TGS k59_754909_2 338966.Ppro_0002 7.81e-15 74.3 COG0592@1|root,COG0592@2|Bacteria,1MVD9@1224|Proteobacteria,42NQW@68525|delta/epsilon subdivisions,2WJZM@28221|Deltaproteobacteria,43T1D@69541|Desulfuromonadales 28221|Deltaproteobacteria L Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria dnaN - 2.7.7.7 ko:K02338 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_beta,DNA_pol3_beta_2,DNA_pol3_beta_3 k59_190660_1 583355.Caka_1998 3.31e-18 82.0 COG1510@1|root,COG1510@2|Bacteria,46YJ6@74201|Verrucomicrobia,3K8GE@414999|Opitutae 414999|Opitutae K regulation of RNA biosynthetic process - - - - - - - - - - - - - k59_1320375_1 1114970.PSF113_5899 3.47e-32 125.0 COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,1RQX2@1236|Gammaproteobacteria,1YS56@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria C FAD linked oxidases, C-terminal domain - - 1.1.3.15 ko:K00104 ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130 - R00475 RC00042 ko00000,ko00001,ko01000 - - - FAD-oxidase_C,FAD_binding_4 k59_1320375_2 72019.SARC_01293T0 0.000197 43.9 COG1171@1|root,KOG1251@2759|Eukaryota 2759|Eukaryota E serine racemase SRR GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006464,GO:0006520,GO:0006563,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016853,GO:0016854,GO:0016855,GO:0017144,GO:0018249,GO:0019538,GO:0019752,GO:0019842,GO:0030170,GO:0030378,GO:0036094,GO:0036211,GO:0036361,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046416,GO:0046437,GO:0046872,GO:0047661,GO:0048037,GO:0050662,GO:0070178,GO:0070179,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 5.1.1.18 ko:K12235,ko:K12580,ko:K14951 ko00260,ko01100,ko03018,map00260,map01100,map03018 - R00589 RC00302 ko00000,ko00001,ko01000,ko03019 3.A.3.10 - - PALP k59_699019_2 1173025.GEI7407_2211 3.61e-46 167.0 COG1002@1|root,COG1002@2|Bacteria,1G393@1117|Cyanobacteria,1H6YG@1150|Oscillatoriales 1117|Cyanobacteria V methylase - - - - - - - - - - - - N6_Mtase k59_1603046_1 394221.Mmar10_0176 2.17e-19 91.7 COG1538@1|root,COG1538@2|Bacteria,1NW1T@1224|Proteobacteria,2U7RK@28211|Alphaproteobacteria,43XCI@69657|Hyphomonadaceae 28211|Alphaproteobacteria MU Outer membrane efflux protein - - - - - - - - - - - - OEP k59_980117_1 436308.Nmar_0574 2.76e-30 107.0 arCOG08736@1|root,arCOG08736@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_980117_2 436308.Nmar_0576 2.24e-21 87.8 COG3576@1|root,arCOG00518@2157|Archaea,41T47@651137|Thaumarchaeota 651137|Thaumarchaeota S Pyridoxamine 5'-phosphate oxidase - - - ko:K07006 - - - - ko00000 - - - Putative_PNPOx k59_699022_1 1517416.IDAT_00650 1.99e-74 234.0 COG2204@1|root,COG2204@2|Bacteria,1MWW5@1224|Proteobacteria,1RND4@1236|Gammaproteobacteria,2QFPQ@267893|Idiomarinaceae 1236|Gammaproteobacteria K Magnesium chelatase, subunit ChlI pspF - - ko:K03974 - - - - ko00000,ko03000 - - - HTH_8,Sigma54_activat k59_472456_1 1089552.KI911559_gene1838 1.16e-19 87.4 COG3387@1|root,COG3387@2|Bacteria,1MV08@1224|Proteobacteria,2TRMQ@28211|Alphaproteobacteria,2JQKZ@204441|Rhodospirillales 204441|Rhodospirillales G Glycosyl hydrolases family 15 - - - - - - - - - - - - Glyco_hydro_15 k59_472456_3 187272.Mlg_0531 1.53e-21 91.3 2E445@1|root,32Z0E@2|Bacteria,1N7FY@1224|Proteobacteria,1SDJE@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_1377591_1 1415778.JQMM01000001_gene2045 1.23e-21 94.7 COG3115@1|root,COG3115@2|Bacteria,1MVHR@1224|Proteobacteria,1RMDB@1236|Gammaproteobacteria,1J6MK@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria D Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring. Also required for the recruitment to the septal ring of downstream cell division proteins zipA GO:0000278,GO:0000281,GO:0000910,GO:0000917,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0007049,GO:0008150,GO:0009987,GO:0016020,GO:0016021,GO:0016043,GO:0022402,GO:0022607,GO:0031224,GO:0031226,GO:0032153,GO:0032506,GO:0044085,GO:0044425,GO:0044459,GO:0044464,GO:0051301,GO:0061640,GO:0071840,GO:0071944,GO:0090529,GO:1902410,GO:1903047 - ko:K03528 - - - - ko00000,ko03036 - - - ZipA_C k59_21355_1 1288826.MSNKSG1_02726 4.58e-06 49.3 COG4992@1|root,COG4992@2|Bacteria,1MV3C@1224|Proteobacteria,1RMV1@1236|Gammaproteobacteria,464Z8@72275|Alteromonadaceae 1236|Gammaproteobacteria E COG4992 Ornithine acetylornithine aminotransferase argD GO:0003674,GO:0003824,GO:0003992,GO:0004069,GO:0005488,GO:0005515,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006553,GO:0006591,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009016,GO:0009058,GO:0009064,GO:0009066,GO:0009067,GO:0009084,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0019752,GO:0019842,GO:0030170,GO:0033359,GO:0036094,GO:0042450,GO:0042802,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046451,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.6.1.11,2.6.1.17,2.6.1.81 ko:K00821,ko:K00840 ko00220,ko00300,ko00330,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map00330,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00028,M00845 R02283,R04217,R04475 RC00006,RC00062 ko00000,ko00001,ko00002,ko01000,ko01007 - - iSFV_1184.SFV_3365,iSF_1195.SF3378,iSFxv_1172.SFxv_3689,iSSON_1240.SSON_3490,iS_1188.S4385 Aminotran_3 k59_811995_1 311402.Avi_5351 9.87e-67 212.0 COG1173@1|root,COG1173@2|Bacteria,1MUG0@1224|Proteobacteria,2VETJ@28211|Alphaproteobacteria,4B73C@82115|Rhizobiaceae 28211|Alphaproteobacteria EP ABC-type dipeptide oligopeptide nickel transport systems, permease components dppC GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - ko:K02034,ko:K12370 ko02010,ko02024,map02010,map02024 M00239,M00324 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1,OppC_N k59_935263_2 1229780.BN381_130127 2.45e-40 150.0 COG1835@1|root,COG1835@2|Bacteria,2GN56@201174|Actinobacteria 201174|Actinobacteria I Acyltransferase - - - - - - - - - - - - Acyl_transf_3 k59_319275_1 1131266.ARWQ01000004_gene1443 1.05e-37 133.0 COG0494@1|root,arCOG01072@2157|Archaea,41STX@651137|Thaumarchaeota 651137|Thaumarchaeota L NUDIX domain - - - - - - - - - - - - NUDIX k59_319275_2 1229909.NSED_07095 2.07e-42 144.0 COG0685@1|root,arCOG00475@2157|Archaea,41SNK@651137|Thaumarchaeota 651137|Thaumarchaeota E cytochrome-c peroxidase activity - - - - - - - - - - - - - k59_1392400_1 1538295.JY96_05885 5.72e-08 58.9 COG1309@1|root,COG1309@2|Bacteria,1QAIA@1224|Proteobacteria,2VRGN@28216|Betaproteobacteria 28216|Betaproteobacteria K Bacterial regulatory proteins, tetR family - - - ko:K16137 - - - - ko00000,ko03000 - - - TetR_N k59_92032_1 1419583.V466_29805 5.31e-44 162.0 COG2989@1|root,COG2989@2|Bacteria,1MV14@1224|Proteobacteria,1RQR7@1236|Gammaproteobacteria,1YPQT@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria S Putative peptidoglycan binding domain ycbB - - ko:K21470 - - - - ko00000,ko01002,ko01011 - - - PG_binding_1,YkuD k59_1562770_1 377629.TERTU_3296 2.24e-265 740.0 COG0443@1|root,COG0443@2|Bacteria,1MVEN@1224|Proteobacteria,1RMDD@1236|Gammaproteobacteria,2PMII@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria O Hsp70 protein dnaK GO:0000166,GO:0000988,GO:0000989,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008144,GO:0008150,GO:0008270,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010033,GO:0010556,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0016989,GO:0017076,GO:0017111,GO:0019219,GO:0019222,GO:0022607,GO:0030554,GO:0031323,GO:0031326,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033554,GO:0034620,GO:0035639,GO:0035966,GO:0035967,GO:0036094,GO:0042221,GO:0043167,GO:0043168,GO:0043169,GO:0043531,GO:0043933,GO:0044085,GO:0044183,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0051171,GO:0051252,GO:0051716,GO:0060255,GO:0061077,GO:0065003,GO:0065007,GO:0070887,GO:0071310,GO:0071840,GO:0071944,GO:0080090,GO:0097159,GO:0097367,GO:0140110,GO:1901265,GO:1901363,GO:1903506,GO:2001141 - ko:K04043 ko03018,ko04212,ko05152,map03018,map04212,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 1.A.33.1 - - HSP70 k59_537966_1 1469557.JSWF01000030_gene3495 8.65e-79 259.0 COG2866@1|root,COG4935@1|root,COG2866@2|Bacteria,COG4935@2|Bacteria,4NEN7@976|Bacteroidetes,1HWMS@117743|Flavobacteriia 976|Bacteroidetes O Metallo-peptidase family M12B Reprolysin-like - - - - - - - - - - - - CHU_C,P_proprotein,Reprolysin_4,TSP_3 k59_319289_1 697282.Mettu_0379 1.65e-27 109.0 COG0711@1|root,COG0712@1|root,COG0711@2|Bacteria,COG0712@2|Bacteria,1R6C0@1224|Proteobacteria,1S4NA@1236|Gammaproteobacteria,1XFA4@135618|Methylococcales 135618|Methylococcales C Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) - - - ko:K02109 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt_B,OSCP k59_319289_2 1415778.JQMM01000001_gene2181 6.11e-21 92.0 COG0056@1|root,COG0056@2|Bacteria,1MUG7@1224|Proteobacteria,1RP4V@1236|Gammaproteobacteria,1J5DU@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit atpA1 - 3.6.3.14 ko:K02111 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - - ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N k59_36161_1 316407.85674641 5.59e-101 300.0 COG2603@1|root,COG2603@2|Bacteria,1N4T5@1224|Proteobacteria,1RPFP@1236|Gammaproteobacteria,3XP1I@561|Escherichia 1236|Gammaproteobacteria J Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA selU GO:0001887,GO:0002097,GO:0002098,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016785,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043828,GO:0044237,GO:0044238,GO:0046483,GO:0070329,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 - ko:K06917 - - - - ko00000,ko01000,ko03016 - - - Rhodanese k59_36161_2 316407.85674640 1.39e-23 91.7 COG2801@1|root,COG2801@2|Bacteria,1MZ45@1224|Proteobacteria,1RSNX@1236|Gammaproteobacteria 1236|Gammaproteobacteria L COG2801 Transposase and inactivated derivatives ylbG - - - - - - - - - - - HTH_29,rve,rve_2,rve_3 k59_319295_1 1279009.ADICEAN_02355 0.000127 45.1 2EHX5@1|root,33BNR@2|Bacteria,4NXNQ@976|Bacteroidetes 976|Bacteroidetes - - - - - - - - - - - - - - - k59_319295_2 1459636.NTE_01128 1.56e-50 166.0 arCOG00516@1|root,arCOG00516@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - Putative_PNPOx k59_1670762_1 1496688.ER33_14355 3.33e-53 187.0 COG2312@1|root,COG2518@1|root,COG2312@2|Bacteria,COG2518@2|Bacteria,1G5KC@1117|Cyanobacteria 1117|Cyanobacteria J Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins pcm GO:0003674,GO:0003824,GO:0004719,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006479,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0010340,GO:0016740,GO:0016741,GO:0019538,GO:0032259,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0051998,GO:0071704,GO:0140096,GO:1901564 2.1.1.77 ko:K00573 - - - - ko00000,ko01000 - - - PCMT k59_1780873_1 158500.BV97_02168 1.45e-92 284.0 COG0719@1|root,COG0719@2|Bacteria,1MVKY@1224|Proteobacteria,2TRU6@28211|Alphaproteobacteria,2K196@204457|Sphingomonadales 204457|Sphingomonadales O ABC-type transport system involved in Fe-S cluster assembly, permease component sufB - - ko:K09014 - - - - ko00000 - - - UPF0051 k59_146215_1 68199.JNZO01000008_gene7686 6.51e-13 73.6 COG1957@1|root,COG1957@2|Bacteria,2GP6N@201174|Actinobacteria 201174|Actinobacteria F nucleoside hydrolase ybeK - 3.2.2.1,3.2.2.8 ko:K01239,ko:K01250,ko:K10213 ko00230,ko00240,ko00760,ko01100,map00230,map00240,map00760,map01100 - R01245,R01273,R01677,R01770,R02137,R02143 RC00033,RC00063,RC00122,RC00318,RC00485 ko00000,ko00001,ko01000 - - - IU_nuc_hydro k59_990851_1 1042876.PPS_3895 6.09e-64 213.0 COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,1RMQ4@1236|Gammaproteobacteria,1YVCQ@136845|Pseudomonas putida group 1236|Gammaproteobacteria IQ PFAM AMP-dependent synthetase and ligase fadD1 - 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding,AMP-binding_C k59_823842_1 195250.CM001776_gene2883 1.78e-15 83.2 COG0265@1|root,COG0265@2|Bacteria,1G0U4@1117|Cyanobacteria,1GYHE@1129|Synechococcus 1117|Cyanobacteria O COG0265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain - - - ko:K08372 ko02020,map02020 - - - ko00000,ko00001,ko01000,ko01002 - - - PDZ_2,Trypsin_2 k59_1392440_1 1415778.JQMM01000001_gene18 2.13e-14 68.9 2EH5A@1|root,33AX7@2|Bacteria,1NK4I@1224|Proteobacteria,1SHSP@1236|Gammaproteobacteria,1JAI5@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_1505479_2 436308.Nmar_0314 2.14e-84 254.0 COG1608@1|root,arCOG00860@2157|Archaea,41SI4@651137|Thaumarchaeota 651137|Thaumarchaeota I Amino acid kinase family - - 2.7.4.26 ko:K06981 ko00900,ko01110,ko01130,map00900,map01110,map01130 - R10093 RC00002 ko00000,ko00001,ko01000 - - - AA_kinase k59_146225_2 436308.Nmar_0186 7.32e-67 206.0 COG0109@1|root,arCOG03103@2157|Archaea,41SNT@651137|Thaumarchaeota 651137|Thaumarchaeota O Cytochrome oxidase assembly protein - - - ko:K02259 ko00190,ko00860,ko01100,ko01110,ko02020,ko04714,map00190,map00860,map01100,map01110,map02020,map04714 M00154 R07412 RC00769 ko00000,ko00001,ko00002,ko03029 3.D.4.4 - - COX15-CtaA k59_1220591_1 436308.Nmar_1131 2.87e-105 312.0 COG2132@1|root,arCOG03914@2157|Archaea,41S77@651137|Thaumarchaeota 651137|Thaumarchaeota Q PFAM Multicopper oxidase - - - - - - - - - - - - Cu-oxidase_2,Cu-oxidase_3 k59_537993_1 545276.KB898728_gene178 3.98e-69 219.0 COG1180@1|root,COG1180@2|Bacteria,1R8XY@1224|Proteobacteria,1T0C7@1236|Gammaproteobacteria,1X2MB@135613|Chromatiales 135613|Chromatiales O Radical SAM superfamily - - 1.97.1.4 ko:K04069 - - R04710 - ko00000,ko01000 - - - Fer4_12,Radical_SAM k59_823859_1 1122137.AQXF01000002_gene347 7e-147 438.0 COG5009@1|root,COG5009@2|Bacteria,1MU5A@1224|Proteobacteria,2USBB@28211|Alphaproteobacteria 28211|Alphaproteobacteria M penicillin-binding protein mrcA - 2.4.1.129,3.4.16.4 ko:K05366 ko00550,ko01100,ko01501,map00550,map01100,map01501 - - - ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 - PCB_OB,Transgly,Transpeptidase k59_482844_1 1120999.JONM01000025_gene3036 6.04e-15 74.3 COG3852@1|root,COG3852@2|Bacteria,1MVN6@1224|Proteobacteria,2VJN7@28216|Betaproteobacteria,2KPMT@206351|Neisseriales 206351|Neisseriales T His Kinase A (phosphoacceptor) domain ntrB - 2.7.13.3 ko:K07708 ko02020,map02020 M00497 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA k59_482844_2 1033802.SSPSH_000418 7.48e-47 165.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria 1236|Gammaproteobacteria T COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains glnG GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - ko:K07712 ko02020,map02020 M00497 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_1780892_2 1042377.AFPJ01000008_gene1988 1.38e-16 77.8 COG4221@1|root,COG4221@2|Bacteria,1RF5D@1224|Proteobacteria,1S5AC@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Belongs to the short-chain dehydrogenases reductases (SDR) family - - - - - - - - - - - - adh_short k59_990863_1 1500890.JQNL01000001_gene1368 1.27e-05 47.8 COG0115@1|root,COG0115@2|Bacteria,1MVB0@1224|Proteobacteria,1RP6Z@1236|Gammaproteobacteria,1X4S5@135614|Xanthomonadales 135614|Xanthomonadales E Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family ilvE - 2.6.1.42 ko:K00826 ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00036,M00119,M00570 R01090,R01214,R02199,R10991 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_4 k59_990863_2 1229909.NSED_01150 1.1e-91 276.0 COG0673@1|root,arCOG01622@2157|Archaea,41SZ6@651137|Thaumarchaeota 651137|Thaumarchaeota S Oxidoreductase family, NAD-binding Rossmann fold - - 1.1.1.374 ko:K18855 - - - - ko00000,ko01000 - - - GFO_IDH_MocA,GFO_IDH_MocA_C k59_652945_1 1122169.AREN01000010_gene2617 8.54e-107 320.0 COG0820@1|root,COG0820@2|Bacteria,1MUYK@1224|Proteobacteria,1RMUI@1236|Gammaproteobacteria,1JD94@118969|Legionellales 118969|Legionellales J Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs rlmN GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0022613,GO:0030488,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140101,GO:0140102,GO:1901360 2.1.1.192 ko:K06941 - - - - ko00000,ko01000,ko03009 - - - Radical_SAM k59_713774_2 1111479.AXAR01000005_gene453 2.52e-44 155.0 COG0745@1|root,COG0745@2|Bacteria,1TPU2@1239|Firmicutes,4IQ5U@91061|Bacilli,279RT@186823|Alicyclobacillaceae 91061|Bacilli T Transcriptional regulatory protein, C terminal - - - - - - - - - - - - Response_reg,Trans_reg_C k59_92080_1 317013.NY99_09640 1.84e-44 164.0 COG2352@1|root,COG2352@2|Bacteria,1MUD5@1224|Proteobacteria,1RPTP@1236|Gammaproteobacteria,1X4MI@135614|Xanthomonadales 135614|Xanthomonadales C Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle ppc GO:0003674,GO:0003824,GO:0004611,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008964,GO:0016829,GO:0016830,GO:0016831,GO:0044424,GO:0044444,GO:0044464 4.1.1.31 ko:K01595 ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200 M00168,M00170,M00171,M00172,M00173,M00346,M00374 R00345 RC02741 ko00000,ko00001,ko00002,ko01000 - - - PEPcase k59_935305_1 1123367.C666_12390 4.02e-33 119.0 COG0386@1|root,COG0386@2|Bacteria,1RD1R@1224|Proteobacteria,2VR4K@28216|Betaproteobacteria,2KWCA@206389|Rhodocyclales 206389|Rhodocyclales O Belongs to the glutathione peroxidase family - - 1.11.1.9 ko:K00432 ko00480,ko00590,ko04918,map00480,map00590,map04918 - R00274,R07034,R07035 RC00011,RC00982 ko00000,ko00001,ko01000 - - - GSHPx k59_935305_2 1120946.AUBF01000004_gene1288 0.000363 48.5 COG0558@1|root,COG0558@2|Bacteria,2GK5D@201174|Actinobacteria,4D4I7@85005|Actinomycetales 201174|Actinobacteria I Belongs to the CDP-alcohol phosphatidyltransferase class-I family pgsA GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0006629,GO:0006644,GO:0006650,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008444,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016740,GO:0016772,GO:0016780,GO:0017169,GO:0019637,GO:0030312,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044464,GO:0045017,GO:0046474,GO:0046486,GO:0071704,GO:0071944,GO:0090407,GO:1901576 2.7.8.41,2.7.8.5 ko:K00995,ko:K08744 ko00564,ko01100,map00564,map01100 - R01801,R02030 RC00002,RC00017,RC02795 ko00000,ko00001,ko01000 - - - CDP-OH_P_transf k59_935305_3 1316936.K678_11835 1.21e-52 192.0 COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,2TRJF@28211|Alphaproteobacteria,2JQ4K@204441|Rhodospirillales 204441|Rhodospirillales L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity polA - 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1 k59_935305_4 55952.BU52_33330 5.99e-10 60.1 COG1960@1|root,COG1960@2|Bacteria,2H504@201174|Actinobacteria 201174|Actinobacteria I Acyl-CoA dehydrogenase, C-terminal domain - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_1392470_1 1229909.NSED_06790 1.54e-05 46.2 COG1064@1|root,arCOG01455@2157|Archaea,41SK3@651137|Thaumarchaeota 651137|Thaumarchaeota C PFAM Alcohol dehydrogenase - - 1.1.1.1 ko:K13953 ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220 - R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310 RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273 ko00000,ko00001,ko01000 - - - ADH_N,ADH_zinc_N k59_1392470_2 1229909.NSED_06795 3.11e-31 112.0 arCOG10408@1|root,arCOG10408@2157|Archaea,41T82@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_600713_1 1484460.JSWG01000009_gene169 2.16e-93 290.0 COG0664@1|root,COG0664@2|Bacteria,4NEWA@976|Bacteroidetes,1HWPV@117743|Flavobacteriia 976|Bacteroidetes T - Catabolite gene activator and regulatory subunit of cAMP-dependent protein - - - - - - - - - - - - - k59_1392473_1 314287.GB2207_09156 2.66e-170 498.0 COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,1RN3H@1236|Gammaproteobacteria,1J53A@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria KT In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance spoT GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0007154,GO:0008150,GO:0008152,GO:0008728,GO:0008893,GO:0009116,GO:0009117,GO:0009119,GO:0009150,GO:0009259,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0015949,GO:0015969,GO:0016020,GO:0016740,GO:0016772,GO:0016778,GO:0016787,GO:0016788,GO:0016794,GO:0019637,GO:0019693,GO:0030312,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0033865,GO:0033875,GO:0034032,GO:0034035,GO:0034641,GO:0042278,GO:0042578,GO:0042594,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046128,GO:0046483,GO:0050896,GO:0051716,GO:0055086,GO:0071496,GO:0071704,GO:0071944,GO:0072521,GO:1901068,GO:1901135,GO:1901360,GO:1901564,GO:1901657 2.7.6.5,3.1.7.2 ko:K00951,ko:K01139 ko00230,map00230 - R00336,R00429 RC00002,RC00078 ko00000,ko00001,ko01000,ko03009 - - iECNA114_1301.ECNA114_3794,iECOK1_1307.ECOK1_4092,iECP_1309.ECP_3748,iECS88_1305.ECS88_4065,iECSF_1327.ECSF_3486,iLF82_1304.LF82_2165,iNRG857_1313.NRG857_18145,iUMN146_1321.UM146_18405,iUTI89_1310.UTI89_C4195,ic_1306.c4475 ACT_4,HD_4,RelA_SpoT,TGS k59_600716_1 330084.JNYZ01000005_gene955 2.25e-40 148.0 COG1167@1|root,COG1167@2|Bacteria,2GM6I@201174|Actinobacteria,4DYS8@85010|Pseudonocardiales 201174|Actinobacteria EK helix_turn_helix gluconate operon transcriptional repressor - - - - - - - - - - - - Aminotran_1_2,GntR k59_884276_1 84531.JMTZ01000021_gene3866 2.42e-27 112.0 COG0171@1|root,COG0388@1|root,COG0171@2|Bacteria,COG0388@2|Bacteria,1MU9U@1224|Proteobacteria,1RNKA@1236|Gammaproteobacteria,1X3Q1@135614|Xanthomonadales 135614|Xanthomonadales H Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source nadE - 6.3.5.1 ko:K01950 ko00760,ko01100,map00760,map01100 M00115 R00257 RC00010,RC00100 ko00000,ko00001,ko00002,ko01000 - - - CN_hydrolase,NAD_synthase k59_1105190_1 1122137.AQXF01000001_gene3361 6.48e-155 479.0 COG2902@1|root,COG2902@2|Bacteria,1MXNV@1224|Proteobacteria,2TS89@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Dehydrogenase gdhB GO:0003674,GO:0003824,GO:0004352,GO:0004353,GO:0008150,GO:0008152,GO:0016491,GO:0016638,GO:0016639,GO:0055114 1.4.1.2 ko:K15371 ko00220,ko00250,ko00430,ko00910,ko01100,map00220,map00250,map00430,map00910,map01100 - R00243 RC00006,RC02799 ko00000,ko00001,ko01000 - - - Bac_GDH k59_1105190_2 1117319.PSPO_04062 5.53e-12 65.5 2EKD9@1|root,315NU@2|Bacteria,1RKEM@1224|Proteobacteria,1S7IA@1236|Gammaproteobacteria,2Q2U7@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_1330723_1 1096930.L284_21885 1.83e-95 297.0 COG1629@1|root,COG4771@2|Bacteria,1MXY7@1224|Proteobacteria,2TV9S@28211|Alphaproteobacteria 28211|Alphaproteobacteria P receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_375897_1 1122137.AQXF01000006_gene751 1.57e-130 382.0 COG0161@1|root,COG0161@2|Bacteria,1MU2N@1224|Proteobacteria,2TQND@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family bioA - 2.6.1.113 ko:K12256 ko00330,ko01100,map00330,map01100 - R08714 RC00008,RC00062 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_3 k59_482868_1 1056816.JAFQ01000004_gene2911 5.02e-51 184.0 COG1201@1|root,COG1201@2|Bacteria,2GJG3@201174|Actinobacteria,4FWCQ@85025|Nocardiaceae 201174|Actinobacteria L DEAD/H associated lhr - - ko:K03724 - - - - ko00000,ko01000,ko03400 - - - DEAD,DEAD_assoc,HTH_42,Helicase_C k59_1392493_1 436308.Nmar_0436 3.72e-28 107.0 COG1382@1|root,arCOG01342@2157|Archaea,41SPD@651137|Thaumarchaeota 651137|Thaumarchaeota O Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding pfdB - - ko:K04798 - - - - ko00000,ko03110 - - - Prefoldin_2 k59_319368_1 700598.Niako_2950 5.37e-43 158.0 COG0457@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria,4NFW7@976|Bacteroidetes,1IR3J@117747|Sphingobacteriia 976|Bacteroidetes K Tetratricopeptide repeat - - - - - - - - - - - - Guanylate_cyc,HTH_18,TPR_16,TPR_2,TPR_8 k59_600738_1 378806.STAUR_1657 2.47e-32 127.0 COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,42M01@68525|delta/epsilon subdivisions,2WUE6@28221|Deltaproteobacteria,2YTX9@29|Myxococcales 28221|Deltaproteobacteria V Efflux ABC transporter, permease ATP-binding protein - - - ko:K06147 - - - - ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran k59_36249_1 1283300.ATXB01000001_gene2405 8.37e-109 320.0 COG0330@1|root,COG0330@2|Bacteria,1MUM8@1224|Proteobacteria,1RNW8@1236|Gammaproteobacteria,1XEH8@135618|Methylococcales 135618|Methylococcales O prohibitin homologues - - - - - - - - - - - - Band_7,Band_7_C k59_1562878_1 1122947.FR7_0873 1.14e-58 201.0 COG3437@1|root,COG3437@2|Bacteria,1UYCB@1239|Firmicutes,4H2H0@909932|Negativicutes 909932|Negativicutes T SMART metal-dependent phosphohydrolase, HD region - - - - - - - - - - - - DUF3369,HD,Response_reg k59_146264_1 1229909.NSED_02215 6.13e-16 73.6 COG0102@1|root,arCOG04242@2157|Archaea,41SP4@651137|Thaumarchaeota 651137|Thaumarchaeota J This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly rpl13 - - ko:K02871 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L13 k59_146264_2 1229909.NSED_02210 2.63e-92 271.0 COG0088@1|root,arCOG04243@2157|Archaea,41SKT@651137|Thaumarchaeota 651137|Thaumarchaeota J Belongs to the universal ribosomal protein uS9 family - - - ko:K02996 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S9 k59_600750_1 198214.SF0757 1.6e-88 260.0 2DPRH@1|root,3333J@2|Bacteria,1ND9B@1224|Proteobacteria,1SEHC@1236|Gammaproteobacteria 1236|Gammaproteobacteria S colanic acid metabolic process mcbA GO:0000271,GO:0005975,GO:0005976,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009242,GO:0009987,GO:0016051,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0046377,GO:0071704,GO:1901135,GO:1901137,GO:1901576 - ko:K13650 - - - - ko00000,ko02048 - - - DUF1471 k59_538035_1 1194165.CAJF01000004_gene2833 6.06e-13 67.8 COG0451@1|root,COG0451@2|Bacteria,2I9T0@201174|Actinobacteria 201174|Actinobacteria GM NAD-dependent epimerase - - - - - - - - - - - - Epimerase k59_539017_1 1137281.D778_02567 1.17e-83 270.0 COG0489@1|root,COG3206@1|root,COG0489@2|Bacteria,COG3206@2|Bacteria,4NEXU@976|Bacteroidetes,1HXKJ@117743|Flavobacteriia 976|Bacteroidetes DM protein involved in exopolysaccharide biosynthesis wzc - - - - - - - - - - - AAA_31,GNVR,Wzz k59_1165544_1 42256.RradSPS_0947 2.25e-17 82.4 COG0642@1|root,COG2202@1|root,COG2461@1|root,COG4191@1|root,COG5002@1|root,COG2202@2|Bacteria,COG2205@2|Bacteria,COG2461@2|Bacteria,COG4191@2|Bacteria,COG5002@2|Bacteria 2|Bacteria T protein histidine kinase activity ETR1 - 2.1.1.80,2.7.13.3,3.1.1.61 ko:K02660,ko:K03406,ko:K07716,ko:K13924 ko02020,ko02025,ko02030,ko04112,map02020,map02025,map02030,map04112 M00506,M00511 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035,ko02044 - - - GAF_2,GGDEF,HATPase_c,HisKA,HisKA_2,PAS,PAS_3,PAS_4,PAS_9,Response_reg,dCache_1 k59_204940_1 1122137.AQXF01000006_gene785 2.37e-87 258.0 COG0853@1|root,COG0853@2|Bacteria,1RI1B@1224|Proteobacteria,2U7BD@28211|Alphaproteobacteria 28211|Alphaproteobacteria H Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine panD - 4.1.1.11 ko:K01579 ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110 M00119 R00489 RC00299 ko00000,ko00001,ko00002,ko01000 - - - Asp_decarbox k59_1106284_1 1207063.P24_04470 1.98e-73 245.0 COG4772@1|root,COG4772@2|Bacteria,1MUIH@1224|Proteobacteria,2TRPJ@28211|Alphaproteobacteria,2JRJ3@204441|Rhodospirillales 204441|Rhodospirillales P TonB dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_377169_1 1415778.JQMM01000001_gene538 2.65e-84 263.0 COG4664@1|root,COG4664@2|Bacteria,1R4MZ@1224|Proteobacteria,1RMR6@1236|Gammaproteobacteria,1J4I5@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria Q COG4664 TRAP-type mannitol chloroaromatic compound transport system, large permease component gtrB - - - - - - - - - - - DctM k59_1671763_1 1163617.SCD_n00952 1.52e-91 286.0 COG1007@1|root,COG1007@2|Bacteria,1MV56@1224|Proteobacteria,2VHWX@28216|Betaproteobacteria 28216|Betaproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoN - 1.6.5.3 ko:K00343 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Proton_antipo_M k59_1671763_2 987059.RBXJA2T_12737 1.02e-10 61.6 COG1008@1|root,COG1008@2|Bacteria,1MV7V@1224|Proteobacteria,2VIAX@28216|Betaproteobacteria,1KK0V@119065|unclassified Burkholderiales 28216|Betaproteobacteria C NADH-quinone oxidoreductase, chain M nuoM - 1.6.5.3 ko:K00342 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q5_N,Proton_antipo_M k59_428511_1 396588.Tgr7_0970 6.04e-60 198.0 COG1420@1|root,COG1420@2|Bacteria,1MVX4@1224|Proteobacteria,1RR2F@1236|Gammaproteobacteria,1WXB7@135613|Chromatiales 135613|Chromatiales K Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons hrcA - - ko:K03705 - - - - ko00000,ko03000 - - - HrcA,HrcA_DNA-bdg k59_766401_1 903818.KI912268_gene2385 1.13e-11 67.4 COG0277@1|root,COG0277@2|Bacteria 2|Bacteria C FAD linked oxidase domain protein - - - - - - - - - - - - FAD-oxidase_C,FAD_binding_4 k59_825352_1 1198114.AciX9_0889 2.69e-18 89.7 COG1792@1|root,COG1792@2|Bacteria,3Y3CK@57723|Acidobacteria,2JIBI@204432|Acidobacteriia 204432|Acidobacteriia M Rod shape-determining protein MreC - - - ko:K03570 - - - - ko00000,ko03036 9.B.157.1 - - MreC k59_1671765_1 391603.FBALC1_12022 2.66e-70 221.0 COG2010@1|root,COG2010@2|Bacteria,4NFMJ@976|Bacteroidetes,1HZ3Y@117743|Flavobacteriia 976|Bacteroidetes C cytochrome C ccoP - - ko:K00406 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00156 - - ko00000,ko00001,ko00002 3.D.4.3 - - Cytochrome_CBB3,FixP_N k59_1671765_2 1349785.BAUG01000056_gene2490 0.000169 43.1 COG2993@1|root,COG3278@1|root,COG2993@2|Bacteria,COG3278@2|Bacteria,4NEGM@976|Bacteroidetes,1HWQ5@117743|Flavobacteriia 976|Bacteroidetes C Belongs to the heme-copper respiratory oxidase family ccoN - 1.9.3.1 ko:K15862 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00156 - - ko00000,ko00001,ko00002,ko01000 3.D.4.3 - - COX1,FixO k59_1617260_1 743299.Acife_3220 0.000607 42.0 COG4453@1|root,COG4453@2|Bacteria 2|Bacteria K Protein conserved in bacteria - - - - - - - - - - - - DUF1778 k59_483969_3 525268.HMPREF0308_2463 8.77e-10 60.5 COG1192@1|root,COG1192@2|Bacteria,2GMU7@201174|Actinobacteria,22JXX@1653|Corynebacteriaceae 201174|Actinobacteria D ATPases involved in chromosome partitioning parA - - ko:K03496 - - - - ko00000,ko03036,ko04812 - - - AAA_31 k59_1393901_1 1123279.ATUS01000001_gene1988 2.19e-126 384.0 COG0855@1|root,COG0855@2|Bacteria,1MUM3@1224|Proteobacteria,1RNRX@1236|Gammaproteobacteria,1J4H9@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) ppk GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0006082,GO:0006091,GO:0006139,GO:0006163,GO:0006165,GO:0006464,GO:0006468,GO:0006725,GO:0006753,GO:0006757,GO:0006793,GO:0006796,GO:0006797,GO:0006799,GO:0006807,GO:0008150,GO:0008152,GO:0008976,GO:0009058,GO:0009117,GO:0009123,GO:0009126,GO:0009132,GO:0009135,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009179,GO:0009185,GO:0009199,GO:0009205,GO:0009259,GO:0009279,GO:0009358,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0016778,GO:0017144,GO:0019538,GO:0019637,GO:0019693,GO:0019867,GO:0030312,GO:0030313,GO:0031241,GO:0031975,GO:0032991,GO:0034641,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0043751,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044425,GO:0044462,GO:0044464,GO:0046031,GO:0046034,GO:0046483,GO:0046777,GO:0046939,GO:0055086,GO:0061695,GO:0071704,GO:0071944,GO:0072521,GO:0098552,GO:1901135,GO:1901360,GO:1901564,GO:1901576,GO:1902494,GO:1990234 2.7.4.1 ko:K00937 ko00190,ko03018,map00190,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - iSbBS512_1146.SbBS512_E2875 PP_kinase,PP_kinase_C,PP_kinase_N k59_602268_1 702113.PP1Y_AT19558 7.52e-86 256.0 COG0225@1|root,COG0225@2|Bacteria,1MVUS@1224|Proteobacteria,2TSAM@28211|Alphaproteobacteria,2K0CZ@204457|Sphingomonadales 204457|Sphingomonadales O Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine msrA - 1.8.4.11 ko:K07304 - - - - ko00000,ko01000 - - - PMSR k59_1564269_1 436308.Nmar_0392 3.04e-111 332.0 COG1866@1|root,arCOG06073@2157|Archaea,41SE5@651137|Thaumarchaeota 651137|Thaumarchaeota C Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA pckA - 4.1.1.49 ko:K01610 ko00010,ko00020,ko00620,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00710,map01100,map01110,map01120,map01130,map01200 M00003,M00170 R00341 RC00002,RC02741 ko00000,ko00001,ko00002,ko01000 - - - PEPCK_ATP k59_825360_1 518766.Rmar_0946 1.35e-46 163.0 COG0078@1|root,COG0078@2|Bacteria,4NEYX@976|Bacteroidetes,1FJUC@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes H Belongs to the ATCase OTCase family argF GO:0000050,GO:0003674,GO:0003824,GO:0004585,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0016743,GO:0019627,GO:0019752,GO:0034641,GO:0042450,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.1.3.11,2.1.3.9 ko:K09065,ko:K13043 ko00220,ko01100,ko01230,map00220,map01100,map01230 M00845 R07245,R08937 RC00096 ko00000,ko00001,ko00002,ko01000 - - - OTCace,OTCace_N k59_262406_1 990073.ATHU01000001_gene1703 1.39e-27 115.0 COG2199@1|root,COG3706@2|Bacteria,1R4U9@1224|Proteobacteria,42PIV@68525|delta/epsilon subdivisions,2YNMC@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria T Cache domain - - - - - - - - - - - - GGDEF,dCache_2 k59_1456291_2 1122137.AQXF01000002_gene487 5.76e-68 208.0 COG0824@1|root,COG0824@2|Bacteria,1RGZN@1224|Proteobacteria,2U95R@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Thioesterase - - - ko:K07107 - - - - ko00000,ko01000 - - - 4HBT,4HBT_2 k59_331448_1 96561.Dole_1174 1.49e-39 145.0 COG1968@1|root,COG1968@2|Bacteria,1MX02@1224|Proteobacteria,42N67@68525|delta/epsilon subdivisions,2WPKC@28221|Deltaproteobacteria,2MJE6@213118|Desulfobacterales 28221|Deltaproteobacteria V Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin uppP - 3.6.1.27 ko:K06153 ko00550,map00550 - R05627 RC00002 ko00000,ko00001,ko01000,ko01011 - - - BacA k59_896863_1 158500.BV97_00733 9.64e-112 342.0 COG0751@1|root,COG0751@2|Bacteria,1MV2F@1224|Proteobacteria,2TQKJ@28211|Alphaproteobacteria,2K16M@204457|Sphingomonadales 204457|Sphingomonadales J Glycyl-tRNA synthetase beta subunit glyS - 6.1.1.14 ko:K01879 ko00970,map00970 M00360 R03654 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DALR_1,tRNA_synt_2f k59_947678_1 316407.85676330 1.33e-91 278.0 COG0477@1|root,COG2814@2|Bacteria,1P8JD@1224|Proteobacteria,1T1SC@1236|Gammaproteobacteria,3XMTT@561|Escherichia 1236|Gammaproteobacteria EGP Multidrug resistance protein MdtL mdtL GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006855,GO:0008150,GO:0015893,GO:0016020,GO:0042221,GO:0042493,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071944 - ko:K07552,ko:K08163 - - - - ko00000,ko02000 2.A.1.2,2.A.1.2.22 - - MFS_1 k59_947678_2 316407.85676329 1.51e-117 342.0 COG0583@1|root,COG0583@2|Bacteria,1R4F5@1224|Proteobacteria,1RRRX@1236|Gammaproteobacteria,3XNGP@561|Escherichia 1236|Gammaproteobacteria K Involved in anaerobic NO protection yidZ GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031326,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576,GO:1903506,GO:2000112,GO:2001141 - - - - - - - - - - HTH_1,LysR_substrate k59_1683301_1 448385.sce2381 2.93e-06 48.1 COG0262@1|root,COG0262@2|Bacteria,1R7YJ@1224|Proteobacteria,42ZF9@68525|delta/epsilon subdivisions,2WUSX@28221|Deltaproteobacteria 28221|Deltaproteobacteria H RibD C-terminal domain - - - - - - - - - - - - RibD_C k59_1683301_2 7159.AAEL006719-PA 4.98e-09 59.7 COG0366@1|root,KOG2212@2759|Eukaryota,38FZ6@33154|Opisthokonta,3BEV2@33208|Metazoa,3CZ5I@33213|Bilateria,41UVV@6656|Arthropoda,3SHUI@50557|Insecta,455SA@7147|Diptera,45ERK@7148|Nematocera 33208|Metazoa G Alpha-amylase - GO:0005575,GO:0005576 3.2.1.1 ko:K01176 ko00500,ko01100,ko04973,map00500,map01100,map04973 - R02108,R02112,R11262 - ko00000,ko00001,ko01000 - GH13 - Alpha-amylase,Alpha-amylase_C k59_273760_1 1280952.HJA_00245 6.58e-109 320.0 COG2370@1|root,COG2370@2|Bacteria,1MV6Z@1224|Proteobacteria,2TSX2@28211|Alphaproteobacteria,43Y5W@69657|Hyphomonadaceae 28211|Alphaproteobacteria O HupE / UreJ protein - - - - - - - - - - - - HupE_UreJ_2 k59_1627946_1 631454.N177_0455 1.19e-18 85.9 COG0246@1|root,COG0246@2|Bacteria,1MVZ7@1224|Proteobacteria,2TRBE@28211|Alphaproteobacteria,1JPWD@119043|Rhodobiaceae 28211|Alphaproteobacteria G Mannitol dehydrogenase Rossmann domain uxuB GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0016491,GO:0016614,GO:0016616,GO:0055114 1.1.1.57 ko:K00040 ko00040,ko01100,map00040,map01100 M00061 R02454 RC00085 ko00000,ko00001,ko00002,ko01000 - - - Mannitol_dh,Mannitol_dh_C k59_1176133_1 562970.Btus_1537 4.8e-17 79.7 COG0779@1|root,COG0779@2|Bacteria,1V6KT@1239|Firmicutes,4HH88@91061|Bacilli,279QR@186823|Alicyclobacillaceae 91061|Bacilli S Required for maturation of 30S ribosomal subunits rimP GO:0000028,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576 - ko:K09748 - - - - ko00000,ko03009 - - - DUF150,DUF150_C k59_1176133_2 1121877.JQKF01000004_gene1125 9.43e-22 93.6 COG0195@1|root,COG0195@2|Bacteria,2GJDJ@201174|Actinobacteria,4CMPR@84992|Acidimicrobiia 84992|Acidimicrobiia K Participates in both transcription termination and antitermination nusA - - ko:K02600 - - - - ko00000,ko03009,ko03021 - - - KH_5,NusA_N,S1 k59_726765_1 382464.ABSI01000023_gene588 1.72e-41 153.0 COG3303@1|root,COG3303@2|Bacteria,46TJS@74201|Verrucomicrobia 74201|Verrucomicrobia C Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process - - - - - - - - - - - - Cytochrom_c3_2 k59_215776_1 1229909.NSED_05650 2.9e-74 231.0 COG1405@1|root,arCOG01981@2157|Archaea,41SXZ@651137|Thaumarchaeota 651137|Thaumarchaeota K Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB) - - - ko:K03124 ko03022,ko05169,ko05203,map03022,map05169,map05203 - - - ko00000,ko00001,ko03021 - - - TFIIB k59_1286582_1 502025.Hoch_6721 3.9e-05 45.1 COG0087@1|root,COG0087@2|Bacteria,1MUST@1224|Proteobacteria,42NV2@68525|delta/epsilon subdivisions,2WNJ1@28221|Deltaproteobacteria,2YV8C@29|Myxococcales 28221|Deltaproteobacteria J One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit rplC - - ko:K02906 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L3 k59_1286583_1 194867.ALBQ01000027_gene2709 1.69e-88 277.0 COG0654@1|root,COG0654@2|Bacteria,1PYKB@1224|Proteobacteria,2UZAF@28211|Alphaproteobacteria,2K8EV@204457|Sphingomonadales 204457|Sphingomonadales CH Tryptophan halogenase - - - - - - - - - - - - Trp_halogenase k59_1792770_1 1415778.JQMM01000001_gene1975 3.4e-138 408.0 COG0441@1|root,COG0441@2|Bacteria,1MUP2@1224|Proteobacteria,1RMYE@1236|Gammaproteobacteria,1J4XI@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) thrS GO:0003674,GO:0003824,GO:0004812,GO:0004829,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006435,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.3 ko:K01868 ko00970,map00970 M00359,M00360 R03663 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,TGS,tRNA-synt_2b,tRNA_SAD k59_1117484_2 1121121.KB894296_gene707 2.6e-62 199.0 COG0461@1|root,COG0461@2|Bacteria,1V1BZ@1239|Firmicutes,4HFV7@91061|Bacilli,26R34@186822|Paenibacillaceae 91061|Bacilli F Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) pyrE - 2.4.2.10 ko:K00762 ko00240,ko01100,map00240,map01100 M00051 R01870 RC00611 ko00000,ko00001,ko00002,ko01000 - - iYO844.BSU15560 Pribosyltran k59_836419_1 393595.ABO_1389 4.93e-81 251.0 COG1354@1|root,COG1354@2|Bacteria,1MVCN@1224|Proteobacteria,1RNBB@1236|Gammaproteobacteria,1XHG7@135619|Oceanospirillales 135619|Oceanospirillales D Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves scpA - - ko:K05896 - - - - ko00000,ko03036 - - - SMC_ScpA k59_1575253_1 1080067.BAZH01000016_gene538 9.84e-06 46.2 COG0132@1|root,COG0132@2|Bacteria,1NPX5@1224|Proteobacteria,1RRRI@1236|Gammaproteobacteria,3WW9S@544|Citrobacter 1236|Gammaproteobacteria H Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring ynfK GO:0003674,GO:0003824,GO:0004141,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016882,GO:0017144,GO:0018130,GO:0019752,GO:0032787,GO:0034641,GO:0042364,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.3.3 ko:K01935 ko00780,ko01100,map00780,map01100 M00123,M00573,M00577 R03182 RC00868 ko00000,ko00001,ko00002,ko01000 - - - AAA_26 k59_1575253_2 316407.1742617 2.03e-81 251.0 COG1940@1|root,COG1940@2|Bacteria,1MX6M@1224|Proteobacteria,1RNZ1@1236|Gammaproteobacteria,3XMPM@561|Escherichia 1236|Gammaproteobacteria K Transcriptional repressor that regulates the expression of proteins that are part of the phosphotransferase system for sugar uptake. Regulates the expression of malT mlc GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097659,GO:1901360,GO:1901362,GO:1901363,GO:1901576 - ko:K15545 - - - - ko00000,ko03000 - - - ROK k59_1456320_1 1088721.NSU_1823 7.12e-100 300.0 COG1473@1|root,COG1473@2|Bacteria,1MUIV@1224|Proteobacteria,2TR5B@28211|Alphaproteobacteria,2K0AI@204457|Sphingomonadales 204457|Sphingomonadales S amidohydrolase - - - - - - - - - - - - M20_dimer,Peptidase_M20 k59_215786_1 1038860.AXAP01000015_gene2096 1.02e-75 249.0 COG1554@1|root,COG1554@2|Bacteria,1MWJE@1224|Proteobacteria,2U1CG@28211|Alphaproteobacteria,3JWWP@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria G Glycosyl hydrolase family 65, C-terminal domain - - 2.4.1.64,5.4.2.6 ko:K01838,ko:K05342 ko00500,ko01100,map00500,map01100 - R02727,R02728,R11310 RC00049,RC00408 ko00000,ko00001,ko01000 - GH65 - Glyco_hydro_65C,Glyco_hydro_65N,Glyco_hydro_65m,HAD_2 k59_947701_1 1380384.JADN01000003_gene510 1.98e-116 344.0 COG0686@1|root,COG0686@2|Bacteria,4NF46@976|Bacteroidetes,1HWVY@117743|Flavobacteriia 976|Bacteroidetes E alanine dehydrogenase - - - - - - - - - - - - AlaDh_PNT_C,AlaDh_PNT_N k59_1792791_1 702113.PP1Y_AT29195 7.09e-60 206.0 COG1197@1|root,COG1197@2|Bacteria,1MUXG@1224|Proteobacteria,2TR2H@28211|Alphaproteobacteria,2K07V@204457|Sphingomonadales 204457|Sphingomonadales L Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site mfd - - ko:K03723 ko03420,map03420 - - - ko00000,ko00001,ko01000,ko03400 - - - CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF k59_1517878_2 1229909.NSED_02270 6.13e-69 213.0 COG1948@1|root,arCOG04206@2157|Archaea,41SIH@651137|Thaumarchaeota 651137|Thaumarchaeota L ERCC4 domain - - - ko:K10848 ko03420,ko03460,map03420,map03460 - - - ko00000,ko00001,ko01000,ko03032,ko03400 - - - ERCC4,HHH_5 k59_1232121_1 1454004.AW11_01686 2.46e-61 205.0 COG1295@1|root,COG1959@1|root,COG1295@2|Bacteria,COG1959@2|Bacteria,1QICW@1224|Proteobacteria,2VPV7@28216|Betaproteobacteria 28216|Betaproteobacteria K Virulence factor BrkB - - - ko:K07058 - - - - ko00000 - - - Virul_fac_BrkB k59_48136_1 1229909.NSED_04415 6.4e-82 246.0 COG0096@1|root,arCOG04091@2157|Archaea,41SMM@651137|Thaumarchaeota 651137|Thaumarchaeota J One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit rps8 - - ko:K02994 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S8 k59_1792796_1 1458275.AZ34_09075 1.68e-12 66.6 COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,2VI3T@28216|Betaproteobacteria,4A9US@80864|Comamonadaceae 28216|Betaproteobacteria I PFAM AMP-dependent synthetase and ligase prpE - 6.2.1.17 ko:K01908 ko00640,ko01100,map00640,map01100 - R00926,R01354 RC00004,RC00043,RC00070,RC02816 ko00000,ko00001,ko01000,ko01004 - - - ACAS_N,AMP-binding,AMP-binding_C k59_1792796_2 1207063.P24_00930 1.06e-46 161.0 COG2271@1|root,COG2271@2|Bacteria,1NJTU@1224|Proteobacteria,2TUBJ@28211|Alphaproteobacteria,2JPTM@204441|Rhodospirillales 204441|Rhodospirillales G COG0477 Permeases of the major facilitator superfamily - - - - - - - - - - - - MFS_1 k59_836442_1 1163617.SCD_n01102 3.01e-49 177.0 COG1629@1|root,COG4771@2|Bacteria,1MUC1@1224|Proteobacteria,2WGU7@28216|Betaproteobacteria 28216|Betaproteobacteria P TonB-dependent Receptor Plug - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_1683331_1 1229909.NSED_02995 3.82e-109 326.0 COG1914@1|root,arCOG04531@2157|Archaea 2157|Archaea P COG1914 Mn2 and Fe2 transporters of the NRAMP family - - - - - - - - - - - - 5TM-5TMR_LYT,Nramp k59_1176177_1 1121912.AUHD01000006_gene1310 1.4e-74 252.0 COG1747@1|root,COG1747@2|Bacteria,4NEB8@976|Bacteroidetes,1HXVQ@117743|Flavobacteriia 976|Bacteroidetes S SprA protein sprA - - - - - - - - - - - SprA_N k59_1342826_1 1192759.AKIB01000069_gene3857 1.53e-101 296.0 2EN4R@1|root,33FSS@2|Bacteria 2|Bacteria S SnoaL-like domain - - - - - - - - - - - - SnoaL_4 k59_1065614_1 1121377.KB906400_gene1350 2.21e-110 327.0 COG0596@1|root,COG0596@2|Bacteria 2|Bacteria S hydrolase activity, acting on ester bonds tadA - 3.5.4.33,3.8.1.5 ko:K01563,ko:K11991 ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120 - R05284,R05367,R05368,R05369,R05370,R07669,R07670,R10223 RC00477,RC01317,RC01340,RC01341,RC02013 ko00000,ko00001,ko01000,ko03016 - - - Abhydrolase_1,Abhydrolase_6,MafB19-deam k59_332505_1 1131269.AQVV01000006_gene491 9.5e-149 432.0 COG0649@1|root,COG0649@2|Bacteria 2|Bacteria C NAD binding nuoD GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0016020,GO:0044424,GO:0044464,GO:0071944 1.6.5.3 ko:K00333,ko:K13378 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_30kDa,Complex1_49kDa k59_332505_2 525904.Tter_1542 3.66e-39 138.0 COG0852@1|root,COG0852@2|Bacteria,2NPN6@2323|unclassified Bacteria 2|Bacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoC GO:0003674,GO:0003824,GO:0003954,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564 1.6.5.3 ko:K00332 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - iAF987.Gmet_3353 Complex1_30kDa k59_440528_1 349124.Hhal_0112 5.97e-41 144.0 COG1376@1|root,COG1376@2|Bacteria,1QVQN@1224|Proteobacteria 1224|Proteobacteria S L,D-transpeptidase catalytic domain - - - - - - - - - - - - YkuD k59_1457434_1 1232410.KI421415_gene3080 2.81e-77 252.0 COG0147@1|root,COG0147@2|Bacteria,1MVBJ@1224|Proteobacteria,42MXN@68525|delta/epsilon subdivisions,2WJN0@28221|Deltaproteobacteria,43T7B@69541|Desulfuromonadales 28221|Deltaproteobacteria EH Anthranilate synthase component I, N terminal region trpE - 4.1.3.27 ko:K01657,ko:K13503 ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025 M00023 R00985,R00986 RC00010,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 - - - Anth_synt_I_N,Chorismate_bind k59_666874_1 68170.KL590528_gene4409 1.35e-12 74.3 COG0515@1|root,COG0515@2|Bacteria,2GIV0@201174|Actinobacteria,4DXFV@85010|Pseudonocardiales 201174|Actinobacteria KLT serine threonine protein kinase - - - - - - - - - - - - Pkinase,Septum_form k59_1233171_1 472759.Nhal_1430 1.2e-69 223.0 COG4992@1|root,COG4992@2|Bacteria,1MV3C@1224|Proteobacteria,1RMV1@1236|Gammaproteobacteria,1WWNU@135613|Chromatiales 135613|Chromatiales E PFAM Aminotransferase class-III - - 2.6.1.13 ko:K00819 ko00330,ko01100,ko01110,ko01130,map00330,map01100,map01110,map01130 - R00667 RC00006,RC00062 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_3 k59_897982_1 1449350.OCH239_13125 2.89e-35 123.0 COG2963@1|root,COG2963@2|Bacteria,1N1AA@1224|Proteobacteria,2UC5K@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Transposase - - - - - - - - - - - - HTH_Tnp_1 k59_897982_2 935840.JAEQ01000006_gene2620 1.78e-16 74.3 COG2801@1|root,COG2801@2|Bacteria,1MVXQ@1224|Proteobacteria,2TU72@28211|Alphaproteobacteria,43K3Q@69277|Phyllobacteriaceae 28211|Alphaproteobacteria L Integrase core domain - - - - - - - - - - - - HTH_21,rve k59_1684384_1 1122137.AQXF01000002_gene519 9.9e-32 123.0 COG0480@1|root,COG0480@2|Bacteria,1MU2W@1224|Proteobacteria,2TYVK@28211|Alphaproteobacteria 28211|Alphaproteobacteria J elongation factor G MA20_05220 - - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2 k59_1684384_2 1122137.AQXF01000002_gene513 1.29e-29 118.0 COG0665@1|root,COG4121@1|root,COG0665@2|Bacteria,COG4121@2|Bacteria,1MZW5@1224|Proteobacteria,2TUNX@28211|Alphaproteobacteria 28211|Alphaproteobacteria J Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 mnmC - 2.1.1.61 ko:K15461 - - R00601,R08702 RC00003,RC00053,RC00060,RC01483 ko00000,ko01000,ko03016 - - - DAO,Methyltransf_30 k59_105219_1 1333998.M2A_0062 1.06e-68 222.0 COG4313@1|root,COG4313@2|Bacteria,1MXNW@1224|Proteobacteria,2TV0V@28211|Alphaproteobacteria 28211|Alphaproteobacteria C Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety - - - - - - - - - - - - OMP_b-brl,Phenol_MetA_deg k59_614683_1 1042377.AFPJ01000043_gene898 1.13e-24 108.0 2A6A4@1|root,30V2R@2|Bacteria,1RENE@1224|Proteobacteria,1SNHE@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_727867_1 1265313.HRUBRA_00303 3.77e-11 62.8 COG2208@1|root,COG2208@2|Bacteria,1QU7V@1224|Proteobacteria,1T1QA@1236|Gammaproteobacteria 1236|Gammaproteobacteria KT response regulator - - 3.1.3.3 ko:K07315 - - - - ko00000,ko01000,ko03021 - - - Response_reg,SpoIIE k59_727867_2 565045.NOR51B_633 4.59e-41 141.0 COG1366@1|root,COG1366@2|Bacteria 2|Bacteria T antisigma factor binding IV02_16530 - - - - - - - - - - - STAS,STAS_2 k59_1343971_1 1096756.ATKN01000005_gene2914 2.34e-44 159.0 COG0715@1|root,COG0715@2|Bacteria,2GK7X@201174|Actinobacteria,1W8D5@1268|Micrococcaceae 201174|Actinobacteria P ABC transporter substrate-binding protein - - - ko:K02051 - M00188 - - ko00000,ko00002,ko02000 3.A.1.16,3.A.1.17 - - NMT1_2 k59_1684408_1 1168065.DOK_14964 1.71e-10 63.9 COG3182@1|root,COG3182@2|Bacteria,1QVX4@1224|Proteobacteria,1T2MJ@1236|Gammaproteobacteria,1J7B0@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S PepSY-associated TM region - - - - - - - - - - - - PepSY_TM k59_1287723_1 1229909.NSED_08925 2.61e-21 96.3 arCOG08793@1|root,arCOG08812@1|root,arCOG08793@2157|Archaea,arCOG08812@2157|Archaea,41SXB@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_440550_1 498211.CJA_2691 7.45e-28 107.0 COG1267@1|root,COG1267@2|Bacteria,1MZJA@1224|Proteobacteria,1S68A@1236|Gammaproteobacteria,1FHD7@10|Cellvibrio 1236|Gammaproteobacteria I Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG) pgpA GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006629,GO:0006644,GO:0006650,GO:0006655,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0008962,GO:0009058,GO:0009987,GO:0010035,GO:0010038,GO:0016020,GO:0016021,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019637,GO:0030258,GO:0031224,GO:0031226,GO:0032026,GO:0042221,GO:0042577,GO:0042578,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044425,GO:0044459,GO:0044464,GO:0045017,GO:0046471,GO:0046474,GO:0046486,GO:0046839,GO:0050896,GO:0071704,GO:0071944,GO:0090407,GO:1901576 3.1.3.27 ko:K01095 ko00564,ko01100,map00564,map01100 - R02029 RC00017 ko00000,ko00001,ko01000 - - iECSP_1301.ECSP_0485,iECUMN_1333.ECUMN_0456,iECs_1301.ECs0471,iG2583_1286.G2583_0529,iPC815.YPO3179,iZ_1308.Z0520 PgpA k59_837602_2 436308.Nmar_0707 2.45e-78 239.0 COG2201@1|root,arCOG02382@2157|Archaea 2157|Archaea NT catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR cheB - 3.1.1.61,3.5.1.44 ko:K03412,ko:K03413 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko02022,ko02035 - - - CheB_methylest,Response_reg k59_1518876_2 1229909.NSED_00590 1.21e-91 277.0 COG1270@1|root,arCOG04274@2157|Archaea,41S6I@651137|Thaumarchaeota 651137|Thaumarchaeota H Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group cobD - 6.3.1.10 ko:K02227 ko00860,ko01100,map00860,map01100 M00122 R06529,R07302 RC00090,RC00096 ko00000,ko00001,ko00002,ko01000 - - - CobD_Cbib k59_948800_1 642227.HA49_13015 8.93e-41 142.0 COG0284@1|root,COG0284@2|Bacteria,1MW2C@1224|Proteobacteria,1RNJR@1236|Gammaproteobacteria,4BUPK@82986|Tatumella 1236|Gammaproteobacteria F Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) pyrF GO:0003674,GO:0003824,GO:0004590,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006206,GO:0006207,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0015949,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019856,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046112,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.1.23 ko:K01591 ko00240,ko01100,map00240,map01100 M00051 R00965 RC00409 ko00000,ko00001,ko00002,ko01000 - - iECO103_1326.ECO103_1444,iECSF_1327.ECSF_1264,iSFV_1184.SFV_1294,iSF_1195.SF1285,iSFxv_1172.SFxv_1457,iS_1188.S1368,ic_1306.c1750 OMPdecase k59_216870_1 1121374.KB891588_gene3411 0.000837 40.8 COG0472@1|root,COG0472@2|Bacteria,1MUTK@1224|Proteobacteria,1RNIG@1236|Gammaproteobacteria 1236|Gammaproteobacteria M First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan mraY GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008963,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016780,GO:0030203,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 2.7.8.13 ko:K01000 ko00550,ko01100,ko01502,map00550,map01100,map01502 - R05629,R05630 RC00002,RC02753 ko00000,ko00001,ko01000,ko01011 9.B.146 - iEC042_1314.EC042_0088,iECABU_c1320.ECABU_c00920,iECED1_1282.ECED1_0088,iECH74115_1262.ECH74115_0095,iECSP_1301.ECSP_0090,iECs_1301.ECs0091,iG2583_1286.G2583_0091,iSDY_1059.SDY_0117,iZ_1308.Z0097,ic_1306.c0105 Glycos_transf_4,MraY_sig1 k59_216870_2 247634.GPB2148_3347 6.69e-93 285.0 COG0771@1|root,COG0771@2|Bacteria,1MVYD@1224|Proteobacteria,1RP25@1236|Gammaproteobacteria,1J5GI@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) murD GO:0000270,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008764,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0030203,GO:0034645,GO:0042546,GO:0042802,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 6.3.2.9 ko:K01925 ko00471,ko00550,ko01100,map00471,map00550,map01100 - R02783 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - iAPECO1_1312.APECO1_1898,iECNA114_1301.ECNA114_0081,iECOK1_1307.ECOK1_0089,iECP_1309.ECP_0090,iECS88_1305.ECS88_0091,iECSF_1327.ECSF_0098,iLF82_1304.LF82_1418,iNRG857_1313.NRG857_00450,iUMN146_1321.UM146_23225,iUTI89_1310.UTI89_C0097 Mur_ligase_C,Mur_ligase_M k59_1629171_1 1255043.TVNIR_1306 6.17e-17 80.9 COG3118@1|root,COG3118@2|Bacteria 2|Bacteria O belongs to the thioredoxin family ybbN GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 - ko:K03671,ko:K05838 ko04621,ko05418,map04621,map05418 - - - ko00000,ko00001,ko03110 - - - TPR_19,TPR_20,Thioredoxin k59_666904_1 402881.Plav_3070 8.44e-58 190.0 COG0183@1|root,COG0183@2|Bacteria,1MU8C@1224|Proteobacteria,2TS6P@28211|Alphaproteobacteria,1JP48@119043|Rhodobiaceae 28211|Alphaproteobacteria I Thiolase, N-terminal domain - - 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C,Thiolase_N k59_1684411_1 1163617.SCD_n02448 3.81e-97 300.0 COG0358@1|root,COG0358@2|Bacteria,1MUHC@1224|Proteobacteria,2VHI9@28216|Betaproteobacteria 28216|Betaproteobacteria L RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication dnaG - - ko:K02316 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - DnaB_bind,DnaG_DnaB_bind,Toprim_2,Toprim_4,Toprim_N,zf-CHC2 k59_1576359_1 1121935.AQXX01000135_gene3704 6.82e-106 322.0 COG0804@1|root,COG0804@2|Bacteria,1MU5P@1224|Proteobacteria,1RN78@1236|Gammaproteobacteria,1XHPP@135619|Oceanospirillales 135619|Oceanospirillales E Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family ureC - 3.5.1.5 ko:K01428 ko00220,ko00230,ko00791,ko01100,ko01120,ko05120,map00220,map00230,map00791,map01100,map01120,map05120 - R00131 RC02798,RC02806 ko00000,ko00001,ko01000 - - - Amidohydro_1,Urease_alpha k59_1576359_2 497321.C664_16485 3.65e-47 153.0 COG0832@1|root,COG0832@2|Bacteria,1RGW0@1224|Proteobacteria,2VSGJ@28216|Betaproteobacteria,2KWUI@206389|Rhodocyclales 206389|Rhodocyclales E Belongs to the urease beta subunit family ureB - 3.5.1.5 ko:K01429 ko00220,ko00230,ko00791,ko01100,ko01120,map00220,map00230,map00791,map01100,map01120 - R00131 RC02798,RC02806 ko00000,ko00001,ko01000 - - - Urease_beta k59_1576359_3 314285.KT71_15771 1.7e-53 170.0 COG0831@1|root,COG0831@2|Bacteria,1RGXE@1224|Proteobacteria,1S65Y@1236|Gammaproteobacteria,1JAGU@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Urease, gamma subunit ureA - 3.5.1.5 ko:K01430,ko:K14048 ko00220,ko00230,ko00791,ko01100,ko01120,ko05120,map00220,map00230,map00791,map01100,map01120,map05120 - R00131 RC02798,RC02806 ko00000,ko00001,ko01000 - - iECH74115_1262.ECH74115_1321,iECO103_1326.ECO103_3797,iECO111_1330.ECO111_1227,iECO26_1355.ECO26_1280,iECSP_1301.ECSP_1249,iECs_1301.ECs1322,iUMNK88_1353.UMNK88_1199,iZ_1308.Z1143,iZ_1308.Z1582 Urease_gamma k59_1576359_4 1211777.BN77_p11224 6.31e-70 224.0 COG0829@1|root,COG0829@2|Bacteria,1QAEB@1224|Proteobacteria,2V6WC@28211|Alphaproteobacteria,4BC8J@82115|Rhizobiaceae 28211|Alphaproteobacteria O UreD urease accessory protein - - - - - - - - - - - - UreD k59_440578_1 396588.Tgr7_0580 1.06e-40 153.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,1RQ5D@1236|Gammaproteobacteria 1236|Gammaproteobacteria NT chemotaxis, protein - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - HAMP,MCPsignal k59_614731_1 1235835.C814_01429 6.77e-45 160.0 COG0034@1|root,COG0034@2|Bacteria,1TPH3@1239|Firmicutes,247RF@186801|Clostridia,3WH6T@541000|Ruminococcaceae 186801|Clostridia F Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine purF - 2.4.2.14 ko:K00764 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048 R01072 RC00010,RC02724,RC02752 ko00000,ko00001,ko00002,ko01000,ko01002 - - - GATase_6,GATase_7,Pribosyltran k59_837629_2 545693.BMQ_2080 2.2e-19 89.4 COG0281@1|root,COG0281@2|Bacteria,1UYHB@1239|Firmicutes,4HDRG@91061|Bacilli,1ZDC7@1386|Bacillus 91061|Bacilli C malic enzyme mleA - 1.1.1.38 ko:K00027 ko00620,ko01200,ko02020,map00620,map01200,map02020 - R00214 RC00105 ko00000,ko00001,ko01000 - - - 2-Hacid_dh_C,ACT_4,Malic_M,THF_DHG_CYH_C,malic k59_159695_1 78245.Xaut_5028 6.84e-20 88.6 COG0212@1|root,COG0212@2|Bacteria,1MZG0@1224|Proteobacteria,2UBY4@28211|Alphaproteobacteria,3EZSD@335928|Xanthobacteraceae 28211|Alphaproteobacteria H Belongs to the 5-formyltetrahydrofolate cyclo-ligase family - - 6.3.3.2 ko:K01934 ko00670,ko01100,map00670,map01100 - R02301 RC00183 ko00000,ko00001,ko01000 - - - 5-FTHF_cyc-lig k59_389694_1 221359.RS9916_36837 1.71e-19 92.8 COG1404@1|root,COG2931@1|root,COG3210@1|root,COG1404@2|Bacteria,COG2931@2|Bacteria,COG3210@2|Bacteria,1GJ0A@1117|Cyanobacteria,1H18T@1129|Synechococcus 1117|Cyanobacteria Q COG3209 Rhs family protein - - - - - - - - - - - - DUF4347 k59_1468421_1 1245475.ANAE01000079_gene3605 1.39e-38 144.0 COG0673@1|root,COG0673@2|Bacteria,2IH5W@201174|Actinobacteria,4EPJ7@85012|Streptosporangiales 201174|Actinobacteria S Oxidoreductase family, NAD-binding Rossmann fold - - - - - - - - - - - - GFO_IDH_MocA,GFO_IDH_MocA_C k59_1804783_1 316407.4902925 1.24e-170 508.0 COG0587@1|root,COG0587@2|Bacteria,1MUIF@1224|Proteobacteria,1RP0K@1236|Gammaproteobacteria,3XMAZ@561|Escherichia 1236|Gammaproteobacteria L DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The alpha chain is the DNA polymerase dnaE GO:0003674,GO:0003824,GO:0003887,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032991,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0042575,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044776,GO:0046483,GO:0061695,GO:0071704,GO:0071897,GO:0090304,GO:0140097,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234 2.7.7.7 ko:K02337 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon k59_451361_1 876044.IMCC3088_2301 1.02e-75 241.0 COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,1RMBQ@1236|Gammaproteobacteria,1J4K2@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Aldehyde dehydrogenase aldh1 - 1.2.1.3,1.2.1.83 ko:K00128,ko:K19700 ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00760,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00760,map00903,map00981,map01100,map01110,map01120,map01130 M00135,M00811 R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146,R10105 RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_506657_1 1278309.KB907109_gene3290 3.27e-19 92.8 COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,1RMQQ@1236|Gammaproteobacteria,1XHV2@135619|Oceanospirillales 135619|Oceanospirillales E acetolactate synthase ilvB-1 - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_788883_1 1122137.AQXF01000001_gene3161 3.74e-155 476.0 COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,1MU7B@1224|Proteobacteria,2TRHQ@28211|Alphaproteobacteria 28211|Alphaproteobacteria E glutamate synthase gltB - 1.4.1.13,1.4.1.14,1.4.7.1 ko:K00265,ko:K00284 ko00250,ko00630,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00630,map00910,map01100,map01110,map01120,map01130,map01230 - R00021,R00093,R00114,R00248,R10086 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - - GATase_2,GXGXG,Glu_syn_central,Glu_synthase k59_506662_1 314287.GB2207_10948 6.15e-71 225.0 COG0148@1|root,COG0148@2|Bacteria,1MU1N@1224|Proteobacteria,1RNQA@1236|Gammaproteobacteria,1J4TX@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria G Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis eno GO:0000015,GO:0000287,GO:0003674,GO:0003824,GO:0004634,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005856,GO:0005975,GO:0006082,GO:0006090,GO:0006091,GO:0006096,GO:0006139,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009986,GO:0009987,GO:0016052,GO:0016053,GO:0016310,GO:0016829,GO:0016835,GO:0016836,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0032991,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042802,GO:0042866,GO:0043167,GO:0043169,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046031,GO:0046034,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046700,GO:0046872,GO:0046939,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1902494 4.2.1.11 ko:K01689 ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066 M00001,M00002,M00003,M00346,M00394 R00658 RC00349 ko00000,ko00001,ko00002,ko01000,ko03019,ko04147 - - iPC815.YPO3376 Enolase_C,Enolase_N k59_506662_2 1149133.ppKF707_0706 2.3e-08 52.4 COG2919@1|root,COG2919@2|Bacteria,1N7AA@1224|Proteobacteria,1SD8H@1236|Gammaproteobacteria,1YGNB@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria D Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic ftsB GO:0000003,GO:0000910,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0007049,GO:0008150,GO:0009987,GO:0019954,GO:0022402,GO:0022414,GO:0030428,GO:0032153,GO:0032505,GO:0042802,GO:0043093,GO:0044464,GO:0051301 - ko:K05589 - - - - ko00000,ko03036 - - - DivIC k59_1298684_1 861299.J421_1669 4.95e-103 307.0 COG0623@1|root,COG0623@2|Bacteria,1ZTGW@142182|Gemmatimonadetes 142182|Gemmatimonadetes I Enoyl-(Acyl carrier protein) reductase - - 1.3.1.10,1.3.1.9 ko:K00208 ko00061,ko00333,ko00780,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01100,map01130,map01212 M00083,M00572 R01404,R04429,R04430,R04724,R04725,R04955,R04956,R04958,R04959,R04961,R04962,R04966,R04967,R04969,R04970,R07765,R10118,R10122,R11671 RC00052,RC00076,RC00120 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 k59_1298684_2 561175.KB894093_gene2769 1.09e-28 112.0 COG2141@1|root,COG2141@2|Bacteria,2GN4N@201174|Actinobacteria,4EGV0@85012|Streptosporangiales 201174|Actinobacteria C Luciferase-like monooxygenase - - - - - - - - - - - - Bac_luciferase k59_506671_2 1415778.JQMM01000001_gene1512 2.94e-52 170.0 COG2885@1|root,COG2885@2|Bacteria,1MYBP@1224|Proteobacteria,1RVRF@1236|Gammaproteobacteria,1J5VX@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Belongs to the ompA family yiaD - - ko:K12216 - - - - ko00000,ko02044 3.A.7.9.1 - - Gly-zipper_Omp,Gly-zipper_YMGG,OmpA k59_904450_1 1122137.AQXF01000002_gene23 1.74e-69 223.0 COG0438@1|root,COG0438@2|Bacteria,1R564@1224|Proteobacteria,2TTA7@28211|Alphaproteobacteria 28211|Alphaproteobacteria M glycosyl transferase group 1 - - - - - - - - - - - - Glyco_transf_4,Glycos_transf_1 k59_1243521_1 246197.MXAN_0791 8.89e-88 274.0 COG0612@1|root,COG0612@2|Bacteria,1MVST@1224|Proteobacteria,42N0H@68525|delta/epsilon subdivisions,2WK9P@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Peptidase M16 - - - ko:K07263 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M16,Peptidase_M16_C k59_1469578_2 431891.A4JWZ7_9CAUD 1.76e-155 464.0 4QBV3@10239|Viruses,4QW0W@35237|dsDNA viruses no RNA stage,4QPPJ@28883|Caudovirales,4QKW5@10699|Siphoviridae 10699|Siphoviridae S Phage Terminase - - - - - - - - - - - - - k59_1469578_3 255131.Q6JIM9_9CAUD 1.87e-65 222.0 4QAYV@10239|Viruses,4QUZ7@35237|dsDNA viruses no RNA stage,4QPU3@28883|Caudovirales,4QKKX@10699|Siphoviridae 10699|Siphoviridae S Phage portal protein - - - - - - - - - - - - - k59_1469578_4 342113.DM82_1137 3.28e-30 119.0 COG3740@1|root,COG3740@2|Bacteria,1N2D8@1224|Proteobacteria,2VWTS@28216|Betaproteobacteria,1K7IS@119060|Burkholderiaceae 28216|Betaproteobacteria S Caudovirus prohead serine protease - - - ko:K06904 - - - - ko00000 - - - Peptidase_S78 k59_1469578_5 990285.RGCCGE502_05075 7.96e-67 226.0 COG4653@1|root,COG4653@2|Bacteria,1MYMH@1224|Proteobacteria,2TUSK@28211|Alphaproteobacteria,4BDCP@82115|Rhizobiaceae 28211|Alphaproteobacteria S Major capsid protein - - - - - - - - - - - - Phage_capsid k59_1469578_9 1437425.CSEC_1931 2.16e-05 51.2 COG1442@1|root,COG1442@2|Bacteria,2JGK0@204428|Chlamydiae 204428|Chlamydiae M Glycosyl transferase family 8 - - - - - - - - - - - - Glyco_transf_8 k59_1469578_10 909943.HIMB100_00022910 7.03e-10 65.5 COG2242@1|root,COG2242@2|Bacteria,1R1YE@1224|Proteobacteria,2TZ6U@28211|Alphaproteobacteria,4BSEQ@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria H Methyltransferase FkbM domain - - - - - - - - - - - - Methyltransf_21 k59_1469578_18 356851.JOAN01000003_gene1443 1.09e-28 108.0 2DIJ3@1|root,303F8@2|Bacteria,2II22@201174|Actinobacteria,4DIWY@85008|Micromonosporales 201174|Actinobacteria - - - - - - - - - - - - - - Phage_tail_2 k59_1469578_19 747763.D7NW61_9CAUD 2.41e-05 49.7 4QGG4@10239|Viruses,4QZ87@35237|dsDNA viruses no RNA stage,4QRCA@28883|Caudovirales,4QKMK@10699|Siphoviridae 10699|Siphoviridae - - - - - - - - - - - - - - - k59_1469578_21 349521.HCH_04545 7.86e-25 118.0 COG5283@1|root,COG5283@2|Bacteria,1QZAD@1224|Proteobacteria,1RYP3@1236|Gammaproteobacteria,1XMG9@135619|Oceanospirillales 135619|Oceanospirillales D nuclear chromosome segregation - - - - - - - - - - - - - k59_1469578_23 443152.MDG893_20549 1.57e-112 397.0 COG4733@1|root,COG4733@2|Bacteria,1R77Q@1224|Proteobacteria,1S1WT@1236|Gammaproteobacteria,469QU@72275|Alteromonadaceae 1236|Gammaproteobacteria S Fibronectin type 3 domain - - - - - - - - - - - - - k59_1469578_30 649639.Bcell_1644 3.77e-07 51.2 COG1396@1|root,COG1396@2|Bacteria,1VAXE@1239|Firmicutes,4HKHB@91061|Bacilli,1ZHZH@1386|Bacillus 91061|Bacilli K transcriptional sinR GO:0008150,GO:0009892,GO:0010468,GO:0010605,GO:0010629,GO:0019222,GO:0048519,GO:0050789,GO:0060255,GO:0065007 - ko:K19449 - - - - ko00000,ko03000 - - - HTH_3,SinI k59_1469578_36 1517681.HW45_03590 2.38e-31 114.0 2E653@1|root,330TW@2|Bacteria,1NEKH@1224|Proteobacteria,1SH74@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_678519_1 1121937.AUHJ01000001_gene749 1.37e-64 214.0 COG2271@1|root,COG2271@2|Bacteria,1QTW2@1224|Proteobacteria,1T3J3@1236|Gammaproteobacteria,469A4@72275|Alteromonadaceae 1236|Gammaproteobacteria G Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 k59_283285_1 402881.Plav_2413 1.01e-63 206.0 COG0275@1|root,COG0275@2|Bacteria,1MUT4@1224|Proteobacteria,2TRQA@28211|Alphaproteobacteria,1JNA2@119043|Rhodobiaceae 28211|Alphaproteobacteria J Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA rsmH GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0070475,GO:0071424,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.199 ko:K03438 - - - - ko00000,ko01000,ko03009 - - - Methyltransf_5 k59_565737_1 413404.Rmag_0594 2.12e-72 233.0 COG1190@1|root,COG1190@2|Bacteria,1MX1V@1224|Proteobacteria,1RMJN@1236|Gammaproteobacteria,1J4CY@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Belongs to the class-II aminoacyl-tRNA synthetase family lysS GO:0003674,GO:0003824,GO:0004812,GO:0004824,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006430,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.6 ko:K04567 ko00970,map00970 M00359,M00360 R03658 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_2,tRNA_anti-codon k59_961005_1 686340.Metal_2967 8.83e-13 67.8 COG0499@1|root,COG0499@2|Bacteria,1MUQ2@1224|Proteobacteria,1RMW8@1236|Gammaproteobacteria,1XDX9@135618|Methylococcales 135618|Methylococcales H May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine ahcY - 3.3.1.1 ko:K01251 ko00270,ko01100,map00270,map01100 M00035 R00192,R04936 RC00056,RC00069,RC01161,RC01243 ko00000,ko00001,ko00002,ko01000,ko01009,ko04147 - - - AdoHcyase,AdoHcyase_NAD k59_961005_2 598467.BrE312_0581 3.78e-104 311.0 COG0192@1|root,COG0192@2|Bacteria,1MUFQ@1224|Proteobacteria,1RNV6@1236|Gammaproteobacteria 1236|Gammaproteobacteria H Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme metK GO:0000096,GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004478,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006534,GO:0006555,GO:0006556,GO:0006575,GO:0006725,GO:0006732,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009066,GO:0009069,GO:0009108,GO:0009116,GO:0009119,GO:0009987,GO:0016740,GO:0016765,GO:0017076,GO:0017144,GO:0019752,GO:0030554,GO:0030955,GO:0031420,GO:0032553,GO:0032555,GO:0032559,GO:0033353,GO:0034641,GO:0035639,GO:0036094,GO:0042278,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046128,GO:0046439,GO:0046483,GO:0046498,GO:0046500,GO:0046872,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0097159,GO:0097367,GO:1901135,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901576,GO:1901605,GO:1901657 2.5.1.6 ko:K00789 ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230 M00034,M00035,M00368,M00609 R00177,R04771 RC00021,RC01211 ko00000,ko00001,ko00002,ko01000 - - iJN746.PP_4967,iYL1228.KPN_03375 S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N k59_602_1 338963.Pcar_3021 1.86e-75 232.0 COG4894@1|root,COG4894@2|Bacteria,1RHRT@1224|Proteobacteria,42TF0@68525|delta/epsilon subdivisions,2WPE4@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Scramblase - - - - - - - - - - - - Scramblase k59_602_2 191610.CATYP_02240 1.57e-12 73.2 COG2230@1|root,COG2230@2|Bacteria,2GJ94@201174|Actinobacteria,22M6K@1653|Corynebacteriaceae 201174|Actinobacteria M Cyclopropane fatty acid synthase and related methyltransferases cfa GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944 2.1.1.79 ko:K00574 - - - - ko00000,ko01000 - - - CMAS k59_607_1 1380600.AUYN01000001_gene2556 1.97e-76 254.0 COG0755@1|root,COG0755@2|Bacteria,4NDY1@976|Bacteroidetes,1HXDN@117743|Flavobacteriia 976|Bacteroidetes O cytochrome c biogenesis ccsA - - - - - - - - - - - Cytochrom_C_asm,ResB k59_283300_1 1088721.NSU_1391 1.66e-17 77.4 COG3951@1|root,COG3951@2|Bacteria,1NG9S@1224|Proteobacteria,2UJMF@28211|Alphaproteobacteria,2K7KR@204457|Sphingomonadales 204457|Sphingomonadales MNO Rod binding protein - - - ko:K02395 - - - - ko00000,ko02035 - - - Rod-binding k59_283300_2 1144305.PMI02_03509 3.14e-43 153.0 COG1256@1|root,COG1256@2|Bacteria,1MV2M@1224|Proteobacteria,2U2HH@28211|Alphaproteobacteria,2K1JD@204457|Sphingomonadales 204457|Sphingomonadales N flagellar hook-associated protein flgK - - ko:K02396 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - Flg_bb_rod,Flg_bbr_C k59_791715_1 1122970.AUHC01000016_gene2593 3.57e-16 79.7 COG1009@1|root,COG2111@1|root,COG1009@2|Bacteria,COG2111@2|Bacteria,1MW2M@1224|Proteobacteria,2TRIR@28211|Alphaproteobacteria,2K1G5@204457|Sphingomonadales 204457|Sphingomonadales CP Domain related to MnhB subunit of Na+/H+ antiporter phaAB - - ko:K05559 - - - - ko00000,ko02000 2.A.63.1 - - DUF4040,MnhB,Proton_antipo_M,Proton_antipo_N k59_791715_2 522306.CAP2UW1_1993 5.42e-28 103.0 COG1006@1|root,COG1006@2|Bacteria,1RH8H@1224|Proteobacteria,2VSVU@28216|Betaproteobacteria,1KQZ1@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria P NADH-ubiquinone/plastoquinone oxidoreductase chain 4L mnhC1 - - ko:K05560 - - - - ko00000,ko02000 2.A.63.1 - - Oxidored_q2 k59_678541_1 1122212.AULO01000010_gene263 1.07e-129 374.0 COG0752@1|root,COG0752@2|Bacteria,1MVCJ@1224|Proteobacteria,1RMYI@1236|Gammaproteobacteria,1XHG1@135619|Oceanospirillales 135619|Oceanospirillales J glycyl-tRNA synthetase alpha subunit glyQ - 6.1.1.14 ko:K01878 ko00970,map00970 M00360 R03654 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_2e k59_961012_1 1155718.KB891886_gene6158 1.13e-54 185.0 COG1136@1|root,COG1136@2|Bacteria,2GIV7@201174|Actinobacteria 201174|Actinobacteria V ABC transporter - - - - - - - - - - - - ABC_tran k59_170117_1 702113.PP1Y_Mpl6750 7.27e-53 183.0 COG0045@1|root,COG1042@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,1MW98@1224|Proteobacteria,2TR24@28211|Alphaproteobacteria,2K9SN@204457|Sphingomonadales 204457|Sphingomonadales C CoA binding domain - - - - - - - - - - - - ATP-grasp_5,CoA_binding_2,Succ_CoA_lig k59_339701_1 595460.RRSWK_06742 2.3e-73 236.0 COG0769@1|root,COG0769@2|Bacteria 2|Bacteria M UDP-N-acetylmuramoylalanyl-D-glutamate-2,6-diaminopimelate ligase activity murE - 6.3.2.13 ko:K01928,ko:K01932 ko00300,ko00550,map00300,map00550 - R02788 RC00064,RC00090 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_791727_1 335543.Sfum_2658 1.8e-38 142.0 COG2204@1|root,COG4191@1|root,COG2204@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42MFW@68525|delta/epsilon subdivisions,2WKMP@28221|Deltaproteobacteria 28221|Deltaproteobacteria T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - GAF_2,HATPase_c,PAS,PAS_3,PAS_9,Response_reg k59_961021_1 1219375.CM002139_gene3523 8.57e-79 248.0 COG0031@1|root,COG0517@1|root,COG0031@2|Bacteria,COG0517@2|Bacteria,1MUBE@1224|Proteobacteria,1RN6J@1236|Gammaproteobacteria,1X4GC@135614|Xanthomonadales 135614|Xanthomonadales E Cystathionine beta-synthase cysB - 4.2.1.22 ko:K01697 ko00260,ko00270,ko01100,ko01130,ko01230,map00260,map00270,map01100,map01130,map01230 M00035,M00338 R00891,R01290,R04942 RC00056,RC00069,RC00256,RC00489,RC01246 ko00000,ko00001,ko00002,ko01000 - - - CBS,PALP k59_735214_1 177439.DP1100 1.33e-15 76.6 COG0108@1|root,COG0807@1|root,COG0108@2|Bacteria,COG0807@2|Bacteria,1MU8P@1224|Proteobacteria,42N1C@68525|delta/epsilon subdivisions,2WIP5@28221|Deltaproteobacteria,2MIF1@213118|Desulfobacterales 28221|Deltaproteobacteria H Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate ribBA - 3.5.4.25,4.1.99.12 ko:K14652 ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110 M00125,M00840 R00425,R07281 RC00293,RC01792,RC01815,RC02504 ko00000,ko00001,ko00002,ko01000 - - - DHBP_synthase,GTP_cyclohydro2 k59_735214_2 998674.ATTE01000001_gene1510 5.22e-54 177.0 COG0307@1|root,COG0307@2|Bacteria,1MUMB@1224|Proteobacteria,1RMSY@1236|Gammaproteobacteria,460GU@72273|Thiotrichales 72273|Thiotrichales H riboflavin synthase, alpha ribE - 2.5.1.9 ko:K00793 ko00740,ko01100,ko01110,map00740,map01100,map01110 M00125 R00066 RC00958,RC00960 ko00000,ko00001,ko00002,ko01000 - - - Lum_binding k59_634_1 1206743.BAGM01000201_gene1143 3.46e-17 90.1 COG3509@1|root,COG3509@2|Bacteria,2IE4T@201174|Actinobacteria,4G8Q5@85025|Nocardiaceae 201174|Actinobacteria Q Esterase PHB depolymerase - - - - - - - - - - - - Esterase_phd k59_396005_1 1122137.AQXF01000003_gene2419 7.41e-103 303.0 COG2159@1|root,COG2159@2|Bacteria,1MUUR@1224|Proteobacteria,2TSQB@28211|Alphaproteobacteria 28211|Alphaproteobacteria S metal-dependent hydrolase of the TIM-barrel fold - - - ko:K07045 - - - - ko00000 - - - Amidohydro_2 k59_396005_2 1122137.AQXF01000003_gene2418 1.6e-51 167.0 COG1846@1|root,COG1846@2|Bacteria,1PVT1@1224|Proteobacteria,2UU1W@28211|Alphaproteobacteria 28211|Alphaproteobacteria K helix_turn_helix multiple antibiotic resistance protein - - - - - - - - - - - - MarR_2 k59_396005_3 1122137.AQXF01000003_gene2416 8.99e-63 195.0 COG0251@1|root,COG0251@2|Bacteria,1MZ3J@1224|Proteobacteria,2UGES@28211|Alphaproteobacteria 28211|Alphaproteobacteria J PFAM Endoribonuclease L-PSP - - - - - - - - - - - - Ribonuc_L-PSP k59_396005_4 744985.HIMB59_00007870 1.22e-16 78.6 COG2857@1|root,COG2857@2|Bacteria,1QFU2@1224|Proteobacteria,2TUHX@28211|Alphaproteobacteria,4BPS4@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria C Cytochrome C1 family petC - - ko:K00413 ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016 M00151,M00152 - - ko00000,ko00001,ko00002 - - - Cytochrom_C1 k59_848094_1 1182553.XP_007745259.1 1.45e-18 82.8 2D2N2@1|root,2SNCW@2759|Eukaryota,3A35J@33154|Opisthokonta,3P3D8@4751|Fungi,3QVJK@4890|Ascomycota,20MZU@147545|Eurotiomycetes,3MWYN@451870|Chaetothyriomycetidae 4751|Fungi E Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - - - - - - - - - - Glyoxalase k59_1196447_3 264198.Reut_B4437 9.76e-13 68.2 COG1845@1|root,COG1845@2|Bacteria,1MUCK@1224|Proteobacteria,2VPW8@28216|Betaproteobacteria,1KGU3@119060|Burkholderiaceae 28216|Betaproteobacteria C cytochrome C norE - 1.9.3.1 ko:K02164,ko:K02276 ko00190,ko01100,map00190,map01100 M00155 R00081,R00294 RC00016,RC02794 ko00000,ko00001,ko00002,ko01000 3.D.4.10,3.D.4.4,3.D.4.6 - - COX3 k59_518120_1 317936.Nos7107_1366 4.32e-77 271.0 COG0515@1|root,COG0642@1|root,COG2114@1|root,COG3899@1|root,COG0515@2|Bacteria,COG2114@2|Bacteria,COG2205@2|Bacteria,COG3899@2|Bacteria 2|Bacteria T PFAM Protein kinase domain - - 4.6.1.1 ko:K01768,ko:K07216 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 - - - AAA_16,GAF,GGDEF,Guanylate_cyc,HATPase_c,HisKA,PAS_4,PAS_9,Pkinase,Response_reg k59_1648378_2 1266925.JHVX01000010_gene1322 1.18e-88 276.0 COG1173@1|root,COG1173@2|Bacteria,1MU26@1224|Proteobacteria,2VHWM@28216|Betaproteobacteria,372BM@32003|Nitrosomonadales 28216|Betaproteobacteria P PFAM binding-protein-dependent transport systems inner membrane component oppC - - ko:K02034 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - BPD_transp_1 k59_405453_1 1380390.JIAT01000016_gene5567 1.63e-50 183.0 COG0178@1|root,COG0178@2|Bacteria,2GJUV@201174|Actinobacteria,4CPHN@84995|Rubrobacteria 84995|Rubrobacteria L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate uvrA - - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - ABC_tran k59_1704690_1 1096930.L284_03065 6.08e-55 181.0 COG0012@1|root,COG0012@2|Bacteria,1MVM4@1224|Proteobacteria,2TRAD@28211|Alphaproteobacteria,2K213@204457|Sphingomonadales 204457|Sphingomonadales J ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner ychF - - ko:K06942 - - - - ko00000,ko03009 - - - MMR_HSR1,YchF-GTPase_C k59_857952_1 1121921.KB898712_gene2206 2.4e-37 131.0 COG0127@1|root,COG0127@2|Bacteria,1MUK5@1224|Proteobacteria,1S27C@1236|Gammaproteobacteria,2PNBT@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria F Ham1 family rdgB GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009141,GO:0009143,GO:0009144,GO:0009146,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0035870,GO:0036220,GO:0036222,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046434,GO:0046483,GO:0046700,GO:0046872,GO:0046983,GO:0047429,GO:0055086,GO:0071704,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576 3.6.1.66 ko:K02428 ko00230,map00230 - R00426,R00720,R01855,R02100,R02720,R03531 RC00002 ko00000,ko00001,ko01000 - - iEC55989_1330.EC55989_3247,iECO111_1330.ECO111_3702,iECSE_1348.ECSE_3222,iECW_1372.ECW_m3212,iEKO11_1354.EKO11_0774,iEcE24377_1341.EcE24377A_3298,iWFL_1372.ECW_m3212 Ham1p_like k59_857952_2 754477.Q7C_1335 1.22e-129 372.0 COG0689@1|root,COG0689@2|Bacteria,1MVFZ@1224|Proteobacteria,1RNTB@1236|Gammaproteobacteria,45ZZN@72273|Thiotrichales 72273|Thiotrichales J Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates rph - 2.7.7.56 ko:K00989 - - - - ko00000,ko01000,ko03016 - - - RNase_PH,RNase_PH_C k59_1309633_1 1321814.HMPREF9089_00722 1.39e-81 253.0 COG0216@1|root,COG0216@2|Bacteria,1TQ7V@1239|Firmicutes,248CN@186801|Clostridia,25V56@186806|Eubacteriaceae 186801|Clostridia J Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA prfA - - ko:K02835 - - - - ko00000,ko03012 - - - PCRF,RF-1 k59_1139734_2 555793.WSK_3210 5.35e-27 102.0 COG4319@1|root,COG4319@2|Bacteria,1NBJ9@1224|Proteobacteria,2UFXN@28211|Alphaproteobacteria,2KAAR@204457|Sphingomonadales 204457|Sphingomonadales S Domain of unknown function (DUF4440) - - - - - - - - - - - - DUF4440 k59_1704702_1 1131266.ARWQ01000009_gene938 2.08e-19 83.2 COG1303@1|root,arCOG01857@2157|Archaea,41SIR@651137|Thaumarchaeota 651137|Thaumarchaeota J Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs - - 2.1.1.206 ko:K07254 - - - - ko00000,ko01000,ko03016 - - - Trm56 k59_1704702_2 416591.Tlet_0783 0.000128 48.1 COG2262@1|root,COG2262@2|Bacteria,2GBX9@200918|Thermotogae 200918|Thermotogae S GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis hflX - - ko:K03665 - - - - ko00000,ko03009 - - - GTP-bdg_M,GTP-bdg_N,MMR_HSR1 k59_631310_1 1249627.D779_4137 1.03e-80 259.0 COG0480@1|root,COG0480@2|Bacteria,1MVVY@1224|Proteobacteria,1RYCE@1236|Gammaproteobacteria,1WWXP@135613|Chromatiales 135613|Chromatiales J small GTP-binding protein - - - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU k59_1648396_1 690597.JH730989_gene3043 1.94e-10 68.2 COG3064@1|root,COG3064@2|Bacteria,1NAPH@1224|Proteobacteria,1SBIW@1236|Gammaproteobacteria,1YUJ8@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria M Domain of unknown function (DUF4350) - - - - - - - - - - - - DUF4350 k59_1027720_1 1442599.JAAN01000030_gene2126 1.27e-08 62.4 COG0739@1|root,COG0739@2|Bacteria,1RK0U@1224|Proteobacteria,1SA4E@1236|Gammaproteobacteria,1XC42@135614|Xanthomonadales 135614|Xanthomonadales M Peptidase family M23 - - - ko:K21472 - - - - ko00000,ko01000,ko01002,ko01011 - - - Peptidase_M23 k59_1196473_1 944547.ABLL_1028 4.59e-30 113.0 COG4665@1|root,COG4665@2|Bacteria,1RHBW@1224|Proteobacteria,42SCS@68525|delta/epsilon subdivisions,2YPIF@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria Q Tripartite ATP-independent periplasmic transporter DctQ component - - - - - - - - - - - - DctQ k59_1139756_1 768671.ThimaDRAFT_2908 6.2e-71 228.0 COG0247@1|root,COG0247@2|Bacteria,1NZIG@1224|Proteobacteria,1RYPW@1236|Gammaproteobacteria,1WXQI@135613|Chromatiales 135613|Chromatiales C 4Fe-4S dicluster domain - - - - - - - - - - - - CCG,Fer4_17,Fer4_8 k59_1139756_2 2340.JV46_15460 4.06e-19 83.6 COG2181@1|root,COG2181@2|Bacteria,1R48S@1224|Proteobacteria,1RYZ2@1236|Gammaproteobacteria 1236|Gammaproteobacteria C PFAM Nitrate reductase gamma subunit dsrM - - - - - - - - - - - Nitrate_red_gam k59_1479452_1 1313421.JHBV01000016_gene5597 1.15e-38 141.0 COG1506@1|root,COG1506@2|Bacteria,4NKM9@976|Bacteroidetes 976|Bacteroidetes E Prolyl oligopeptidase family - - - - - - - - - - - - Peptidase_S9 k59_1479452_2 1121937.AUHJ01000004_gene1140 1.1e-10 62.4 COG0154@1|root,COG0154@2|Bacteria,1MW3Z@1224|Proteobacteria,1RP33@1236|Gammaproteobacteria,464XC@72275|Alteromonadaceae 1236|Gammaproteobacteria J Amidase - - 6.3.5.6,6.3.5.7 ko:K02433 ko00970,ko01100,map00970,map01100 - R03905,R04212 RC00010 ko00000,ko00001,ko01000,ko03029 - - - Amidase k59_123232_1 1208321.D104_06140 6.3e-40 143.0 COG0809@1|root,COG0809@2|Bacteria,1MUH3@1224|Proteobacteria,1RMKW@1236|Gammaproteobacteria,1XH6Q@135619|Oceanospirillales 135619|Oceanospirillales J Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) queA - 2.4.99.17 ko:K07568 - - - - ko00000,ko01000,ko03016 - - - Queuosine_synth k59_1196483_1 1282360.ABAC460_15085 5.64e-43 148.0 2DMP1@1|root,32SS8@2|Bacteria,1N6W6@1224|Proteobacteria,2VGQF@28211|Alphaproteobacteria 1224|Proteobacteria S Protein of unknown function (DUF3237) - - - - - - - - - - - - DUF3237 k59_1366121_1 269482.Bcep1808_2141 7.47e-134 390.0 COG3039@1|root,COG3039@2|Bacteria,1MVDK@1224|Proteobacteria,2VI1H@28216|Betaproteobacteria,1K3UX@119060|Burkholderiaceae 28216|Betaproteobacteria L PFAM transposase, IS4 family protein - - - ko:K07481 - - - - ko00000 - - - DDE_Tnp_1,DUF772 k59_1253109_2 1535287.JP74_08060 6.62e-07 53.1 2FFJC@1|root,347GU@2|Bacteria,1P0D9@1224|Proteobacteria,2UV3U@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_67024_1 159450.NH14_20025 1.66e-78 247.0 COG0641@1|root,COG0641@2|Bacteria,1MX3M@1224|Proteobacteria,2VYFJ@28216|Betaproteobacteria,1K4C2@119060|Burkholderiaceae 28216|Betaproteobacteria C Radical SAM superfamily - - - ko:K06871 - - - - ko00000 - - - Fer4_12,Radical_SAM,SPASM k59_858008_1 1283300.ATXB01000001_gene690 2.35e-05 48.1 2B7TJ@1|root,32102@2|Bacteria,1RHKS@1224|Proteobacteria,1S7PY@1236|Gammaproteobacteria,1XGWG@135618|Methylococcales 135618|Methylococcales S Domain of unknown function (DUF5063) - - - - - - - - - - - - DUF5063 k59_518167_1 1088721.NSU_2724 1.23e-127 385.0 COG4774@1|root,COG4774@2|Bacteria,1PIT1@1224|Proteobacteria,2TR52@28211|Alphaproteobacteria,2K2XI@204457|Sphingomonadales 204457|Sphingomonadales P TonB dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_969914_1 1304883.KI912532_gene2773 5.11e-21 94.0 COG1638@1|root,COG1638@2|Bacteria,1PMWE@1224|Proteobacteria,2VNJI@28216|Betaproteobacteria 28216|Betaproteobacteria G Bacterial extracellular solute-binding protein, family 7 - - - - - - - - - - - - DctP k59_1422108_1 1331060.RLDS_04905 1.41e-14 74.7 COG4638@1|root,COG4638@2|Bacteria,1R4IX@1224|Proteobacteria,2U0IQ@28211|Alphaproteobacteria,2K1CE@204457|Sphingomonadales 204457|Sphingomonadales P Rieske 2Fe-2S - - - - - - - - - - - - Rieske,Ring_hydroxyl_A k59_1422108_2 1380386.JIAW01000010_gene4104 8.47e-20 86.3 COG2188@1|root,COG2188@2|Bacteria,2IAW7@201174|Actinobacteria,235M7@1762|Mycobacteriaceae 201174|Actinobacteria K transcriptional - - - - - - - - - - - - GntR,UTRA k59_1027746_1 1125863.JAFN01000001_gene2915 1.57e-101 305.0 COG0001@1|root,COG0001@2|Bacteria,1MUY5@1224|Proteobacteria,42MBF@68525|delta/epsilon subdivisions,2WJQ2@28221|Deltaproteobacteria 28221|Deltaproteobacteria H PFAM Aminotransferase class-III hemL - 5.4.3.8 ko:K01845 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R02272 RC00677 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 k59_1366139_1 1163409.UUA_12273 8.74e-54 189.0 COG0751@1|root,COG0751@2|Bacteria,1MV2F@1224|Proteobacteria,1RNR3@1236|Gammaproteobacteria,1X31Q@135614|Xanthomonadales 135614|Xanthomonadales J Glycyl-tRNA synthetase beta subunit glyS - 6.1.1.14 ko:K01879 ko00970,map00970 M00360 R03654 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - DALR_1,tRNA_synt_2f k59_631340_1 1265313.HRUBRA_01492 4.37e-117 341.0 COG1442@1|root,COG1442@2|Bacteria,1R5NA@1224|Proteobacteria,1SJX1@1236|Gammaproteobacteria 1236|Gammaproteobacteria M glycosyl transferase family 8 - - - - - - - - - - - - - k59_1422120_1 398767.Glov_2167 8e-76 234.0 COG1137@1|root,COG1137@2|Bacteria,1MU8M@1224|Proteobacteria,42M4J@68525|delta/epsilon subdivisions,2WJM8@28221|Deltaproteobacteria,43T7P@69541|Desulfuromonadales 28221|Deltaproteobacteria S PFAM ABC transporter related lptB - - ko:K06861 ko02010,map02010 M00320 - - ko00000,ko00001,ko00002,ko01000,ko02000 1.B.42.1 - - ABC_tran,BCA_ABC_TP_C k59_1253139_3 68219.JNXI01000003_gene4906 1.33e-91 285.0 2F09Z@1|root,33TD7@2|Bacteria,2IAJA@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - - k59_1253139_5 1463900.JOIX01000006_gene749 1.24e-42 147.0 2F1HE@1|root,33UHX@2|Bacteria,2IH41@201174|Actinobacteria 201174|Actinobacteria - - - - - - - - - - - - - - - k59_1535376_1 436308.Nmar_0352 4.55e-34 119.0 COG1911@1|root,arCOG01752@2157|Archaea,41SW9@651137|Thaumarchaeota 651137|Thaumarchaeota J PFAM ribosomal protein L7Ae L30e S12e Gadd45 - - - ko:K02908 ko03010,map03010 M00177,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L7Ae k59_1535376_2 436308.Nmar_0353 4.84e-95 278.0 COG0195@1|root,arCOG01760@2157|Archaea,41SJQ@651137|Thaumarchaeota 651137|Thaumarchaeota K Participates in transcription termination nusA - - ko:K02600 - - - - ko00000,ko03009,ko03021 - - - KH_2 k59_123283_1 1122135.KB893167_gene2349 1.36e-44 158.0 COG0679@1|root,COG0679@2|Bacteria,1P2SH@1224|Proteobacteria,2TSPG@28211|Alphaproteobacteria 28211|Alphaproteobacteria S auxin efflux carrier family protein - - - ko:K07088 - - - - ko00000 - - - Mem_trans k59_123283_2 1123393.KB891316_gene1731 1.94e-10 63.2 COG2010@1|root,COG2010@2|Bacteria,1N63J@1224|Proteobacteria,2VVMT@28216|Betaproteobacteria,1KT5P@119069|Hydrogenophilales 119069|Hydrogenophilales C Cytochrome C oxidase, cbb3-type, subunit III - - - - - - - - - - - - Cytochrome_CBB3 k59_123283_3 870187.Thini_1224 3.02e-21 84.3 COG0267@1|root,COG0267@2|Bacteria,1N6QV@1224|Proteobacteria,1SCEJ@1236|Gammaproteobacteria 1236|Gammaproteobacteria J Belongs to the bacterial ribosomal protein bL33 family rpmG GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042221,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046677,GO:0050896,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02913 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L33 k59_1422132_1 1323361.JPOC01000020_gene2480 1.46e-98 302.0 COG1012@1|root,COG1012@2|Bacteria,2GIWZ@201174|Actinobacteria,4FTXB@85025|Nocardiaceae 201174|Actinobacteria C Belongs to the aldehyde dehydrogenase family - - - - - - - - - - - - Aldedh k59_687929_1 935565.JAEM01000001_gene548 6.72e-45 164.0 COG3276@1|root,COG3276@2|Bacteria,1MWXH@1224|Proteobacteria,2TUFY@28211|Alphaproteobacteria,2PVHK@265|Paracoccus 28211|Alphaproteobacteria J Elongation factor SelB, winged helix - - - ko:K03833 - - - - ko00000,ko03012 - - - GTP_EFTU,GTP_EFTU_D2,SelB-wing_2,SelB-wing_3 k59_574883_1 555793.WSK_1074 2.43e-09 57.4 COG0642@1|root,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,2U3HG@28211|Alphaproteobacteria,2K0AE@204457|Sphingomonadales 204457|Sphingomonadales T Histidine kinase - - - - - - - - - - - - HATPase_c,HisKA k59_574883_2 983920.Y88_0803 8.43e-12 68.6 COG0645@1|root,COG0645@2|Bacteria 2|Bacteria S AAA domain - - 2.7.1.25 ko:K00860,ko:K07028 ko00230,ko00920,ko01100,ko01120,map00230,map00920,map01100,map01120 M00176 R00509,R04928 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - AAA_33 k59_1139806_1 1227739.Hsw_4212 1.58e-27 110.0 COG4675@1|root,COG4675@2|Bacteria,4NPGY@976|Bacteroidetes,47QEG@768503|Cytophagia 976|Bacteroidetes S Phage Tail Collar Domain - - - - - - - - - - - - Collar k59_913917_1 100226.SCO2438 5.78e-27 116.0 COG0654@1|root,COG0654@2|Bacteria,2GK7I@201174|Actinobacteria 201174|Actinobacteria CH tryptophan 2,3-dioxygenase activity - - - - - - - - - - - - FAD_binding_2,FAD_binding_3,FAD_oxidored k59_1422151_1 1150626.PHAMO_210250 2.38e-49 168.0 COG0604@1|root,COG0604@2|Bacteria,1MX8A@1224|Proteobacteria,2TR1J@28211|Alphaproteobacteria,2JPHC@204441|Rhodospirillales 204441|Rhodospirillales C COG0604 NADPH quinone reductase and related Zn-dependent oxidoreductases - - 1.6.5.5 ko:K00344 - - - - ko00000,ko01000 - - - ADH_N,ADH_zinc_N k59_1422151_2 1121921.KB898707_gene1050 1.15e-123 360.0 COG0039@1|root,COG0039@2|Bacteria,1MV57@1224|Proteobacteria,1RMAX@1236|Gammaproteobacteria,2PMUK@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria C lactate/malate dehydrogenase, NAD binding domain mdh GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006107,GO:0006108,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006734,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009060,GO:0009117,GO:0009987,GO:0015980,GO:0016491,GO:0016614,GO:0016615,GO:0016616,GO:0016999,GO:0017144,GO:0019362,GO:0019637,GO:0019674,GO:0019752,GO:0030060,GO:0034641,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044464,GO:0045333,GO:0046483,GO:0046496,GO:0051186,GO:0055086,GO:0055114,GO:0071704,GO:0072350,GO:0072524,GO:1901360,GO:1901564 1.1.1.37 ko:K00024 ko00020,ko00270,ko00620,ko00630,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00270,map00620,map00630,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740 R00342,R07136 RC00031 ko00000,ko00001,ko00002,ko01000 - - - Ldh_1_C,Ldh_1_N k59_1253175_1 697282.Mettu_2131 1.95e-19 89.4 COG0633@1|root,COG1018@1|root,COG0633@2|Bacteria,COG1018@2|Bacteria,1REP4@1224|Proteobacteria,1T2XC@1236|Gammaproteobacteria,1XGZ2@135618|Methylococcales 135618|Methylococcales C Oxidoreductase FAD-binding domain - - - - - - - - - - - - FAD_binding_6,Fer2,NAD_binding_1 k59_1761416_1 1122137.AQXF01000004_gene1618 7.3e-28 106.0 COG3474@1|root,COG3474@2|Bacteria,1RIDN@1224|Proteobacteria,2U142@28211|Alphaproteobacteria 28211|Alphaproteobacteria C cytochrome cycM - - ko:K08738 ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416 M00595 R10151 RC03151,RC03152 ko00000,ko00001,ko00002 3.D.4.6 - - Cytochrom_C k59_1761416_2 1122137.AQXF01000004_gene1617 4.89e-19 84.0 COG0077@1|root,COG0077@2|Bacteria,1MU60@1224|Proteobacteria,2TSUT@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Prephenate dehydratase pheA - 4.2.1.51 ko:K04518 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00024 R00691,R01373 RC00360 ko00000,ko00001,ko00002,ko01000 - - - PDT k59_1309716_1 1121354.AQUV01000003_gene77 8.91e-67 221.0 COG0028@1|root,COG0028@2|Bacteria,2GKU4@201174|Actinobacteria,22KJ0@1653|Corynebacteriaceae 201174|Actinobacteria H Thiamine pyrophosphate-requiring enzymes acetolactate synthase pyruvate dehydrogenase (cytochrome) glyoxylate carboligase phosphonopyruvate decarboxylase ilvB GO:0000287,GO:0003674,GO:0003824,GO:0003984,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0006082,GO:0006520,GO:0006549,GO:0006573,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009097,GO:0009099,GO:0009987,GO:0016053,GO:0016740,GO:0016744,GO:0019752,GO:0019842,GO:0030312,GO:0030976,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0046872,GO:0048037,GO:0050662,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1901681 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - iNJ661.Rv3003c TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_1253179_1 243365.CV_1318 7.36e-82 263.0 COG0326@1|root,COG0326@2|Bacteria,1MUUE@1224|Proteobacteria,2VHHJ@28216|Betaproteobacteria,2KQDA@206351|Neisseriales 206351|Neisseriales O Molecular chaperone. Has ATPase activity htpG - - ko:K04079 ko04141,ko04151,ko04217,ko04612,ko04621,ko04626,ko04657,ko04659,ko04914,ko04915,ko05200,ko05215,ko05418,map04141,map04151,map04217,map04612,map04621,map04626,map04657,map04659,map04914,map04915,map05200,map05215,map05418 - - - ko00000,ko00001,ko01009,ko03029,ko03051,ko03110,ko04131,ko04147 - - - HATPase_c,HATPase_c_3,HSP90 k59_1422160_1 1500893.JQNB01000001_gene1746 2.94e-26 107.0 COG3358@1|root,COG3358@2|Bacteria,1R9CT@1224|Proteobacteria,1SP2S@1236|Gammaproteobacteria,1X42J@135614|Xanthomonadales 135614|Xanthomonadales S Protein of unknown function (DUF1684) - - - ko:K09164 - - - - ko00000 - - - DUF1684 k59_1648483_1 573370.DMR_33800 5.65e-27 111.0 COG2064@1|root,COG2064@2|Bacteria,1MWAZ@1224|Proteobacteria,42R2X@68525|delta/epsilon subdivisions,2WMU1@28221|Deltaproteobacteria,2MAZ8@213115|Desulfovibrionales 28221|Deltaproteobacteria NU PFAM Type II secretion system F - - - ko:K12511 - - - - ko00000,ko02044 - - - T2SSF k59_1196555_1 59538.XP_005966935.1 2.76e-40 152.0 COG0415@1|root,KOG0133@2759|Eukaryota,38BKX@33154|Opisthokonta,3B995@33208|Metazoa,3CX0G@33213|Bilateria,480B2@7711|Chordata,48ZHT@7742|Vertebrata,3J7G6@40674|Mammalia,4IWA6@91561|Cetartiodactyla 33208|Metazoa LT Cryptochrome circadian clock 2 - - 4.1.99.3 ko:K01669 - - - - ko00000,ko01000,ko03400 - - - DNA_photolyase,FAD_binding_7 k59_1761427_1 367299.JOEE01000006_gene794 9.63e-13 69.3 COG1131@1|root,COG1131@2|Bacteria,2GKWB@201174|Actinobacteria,4FF7X@85021|Intrasporangiaceae 201174|Actinobacteria V ATPases associated with a variety of cellular activities - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_235780_1 1045855.DSC_03230 6.7e-36 132.0 COG2063@1|root,COG2063@2|Bacteria,1RDEY@1224|Proteobacteria,1S3XK@1236|Gammaproteobacteria,1X4EI@135614|Xanthomonadales 135614|Xanthomonadales N Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation flgH - - ko:K02393 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - FlgH k59_1705437_1 436308.Nmar_1322 1.18e-42 152.0 COG3569@1|root,arCOG08649@2157|Archaea,41SDH@651137|Thaumarchaeota 651137|Thaumarchaeota L DNA Topoisomerase I (eukaryota) - - 5.99.1.2 ko:K03163 - - - - ko00000,ko01000,ko03032 - - - Topo_C_assoc,Topoisom_I,Topoisom_I_N k59_236460_2 269084.syc1560_d 9.31e-15 70.5 COG0298@1|root,COG0298@2|Bacteria,1G9FZ@1117|Cyanobacteria,1H1PR@1129|Synechococcus 1117|Cyanobacteria O HupF/HypC family hypC - - ko:K04653 - - - - ko00000 - - - HupF_HypC k59_236460_3 1496688.ER33_08240 7.34e-33 125.0 COG0409@1|root,COG0409@2|Bacteria,1G0NJ@1117|Cyanobacteria,22S8E@167375|Cyanobium 1117|Cyanobacteria O formation protein hypD - - ko:K04654 - - - - ko00000 - - - HypD k59_688679_1 1089551.KE386572_gene3406 6.12e-84 262.0 COG1109@1|root,COG1109@2|Bacteria,1MUA5@1224|Proteobacteria,2TRIJ@28211|Alphaproteobacteria,4BPB9@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria G Phosphoglucomutase/phosphomannomutase, C-terminal domain exoC - 5.4.2.2,5.4.2.8 ko:K01840,ko:K15778 ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130 M00114 R00959,R01057,R01818,R08639 RC00408 ko00000,ko00001,ko00002,ko01000 - - - PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV k59_1253939_1 1114964.L485_07475 5.49e-16 86.3 COG1629@1|root,COG4771@2|Bacteria,1MU9K@1224|Proteobacteria,2TTJG@28211|Alphaproteobacteria,2JZUI@204457|Sphingomonadales 204457|Sphingomonadales P COG1629 Outer membrane receptor proteins, mostly Fe transport - - - - - - - - - - - - Plug,TonB_dep_Rec k59_123990_1 258533.BN977_00280 1.33e-29 130.0 COG2133@1|root,COG2133@2|Bacteria,2GISM@201174|Actinobacteria,237P0@1762|Mycobacteriaceae 201174|Actinobacteria G Glucose sorbosone - - - - - - - - - - - - GSDH,PKD k59_802097_1 1349767.GJA_4625 2.26e-72 231.0 COG0758@1|root,COG0758@2|Bacteria,1MVF6@1224|Proteobacteria,2VH3W@28216|Betaproteobacteria,47340@75682|Oxalobacteraceae 28216|Betaproteobacteria LU DNA recombination-mediator protein A smf - - ko:K04096 - - - - ko00000 - - - DNA_processg_A k59_1649203_1 76114.ebA843 7.48e-30 115.0 COG0536@1|root,COG0536@2|Bacteria,1MUGZ@1224|Proteobacteria,2VIM2@28216|Betaproteobacteria,2KUQC@206389|Rhodocyclales 206389|Rhodocyclales S An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control obg - - ko:K03979 - - - - ko00000,ko01000,ko03009 - - - GTP1_OBG,MMR_HSR1 k59_1649203_2 999541.bgla_1g05210 2.23e-36 124.0 COG0211@1|root,COG0211@2|Bacteria,1MZGH@1224|Proteobacteria,2VU4W@28216|Betaproteobacteria,1K8IM@119060|Burkholderiaceae 28216|Betaproteobacteria J Belongs to the bacterial ribosomal protein bL27 family rpmA - - ko:K02899 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L27 k59_1649203_3 305700.B447_17716 2.35e-44 146.0 COG0261@1|root,COG0261@2|Bacteria,1MZEW@1224|Proteobacteria,2VSHZ@28216|Betaproteobacteria,2KWM1@206389|Rhodocyclales 206389|Rhodocyclales J This protein binds to 23S rRNA in the presence of protein L20 rplU - - ko:K02888 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L21p k59_632068_1 1415778.JQMM01000001_gene1180 7.65e-98 310.0 COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,1RMS9@1236|Gammaproteobacteria,1J57N@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate uvrA GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009314,GO:0009380,GO:0009381,GO:0009628,GO:0009987,GO:0016462,GO:0016787,GO:0016788,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032991,GO:0033554,GO:0034641,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1902494,GO:1905347,GO:1905348,GO:1990391 - ko:K03701 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - ABC_tran k59_1028545_1 316407.85676183 5.44e-124 364.0 COG2211@1|root,COG2211@2|Bacteria,1QPAN@1224|Proteobacteria,1S0SW@1236|Gammaproteobacteria 1236|Gammaproteobacteria G transporter yihO GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008324,GO:0015075,GO:0015291,GO:0015293,GO:0015294,GO:0015318,GO:0016020,GO:0022804,GO:0022857,GO:0022890,GO:0034220,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0072348,GO:0098655,GO:1901682 - ko:K03292 - - - - ko00000 2.A.2 - - MFS_2 k59_293686_1 1123253.AUBD01000009_gene2352 3.33e-18 85.9 28H52@1|root,2Z7HQ@2|Bacteria,1MXTF@1224|Proteobacteria,1RN8H@1236|Gammaproteobacteria,1X4IZ@135614|Xanthomonadales 135614|Xanthomonadales S Protein of unknown function (DUF1329) - - - - - - - - - - - - DUF1329 k59_293686_2 1121033.AUCF01000012_gene984 2.08e-122 384.0 COG3203@1|root,COG3203@2|Bacteria,1MXEB@1224|Proteobacteria,2U8WW@28211|Alphaproteobacteria,2JSKJ@204441|Rhodospirillales 204441|Rhodospirillales M Protein of unknown function (DUF1302) - - - - - - - - - - - - DUF1302 k59_970708_1 1265502.KB905938_gene2424 9.46e-116 346.0 COG3829@1|root,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria,2VHQ9@28216|Betaproteobacteria,4AAAF@80864|Comamonadaceae 28216|Betaproteobacteria K PFAM sigma-54 factor interaction domain-containing protein - - - - - - - - - - - - HTH_8,PAS_4,Sigma54_activat k59_302111_2 436308.Nmar_1568 1.4e-50 165.0 arCOG08827@1|root,arCOG08827@2157|Archaea,41SUW@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1544559_1 349124.Hhal_0889 5.71e-27 114.0 COG0815@1|root,COG0815@2|Bacteria,1MUBU@1224|Proteobacteria,1RM8M@1236|Gammaproteobacteria,1WWSQ@135613|Chromatiales 135613|Chromatiales M Transfers the fatty acyl group on membrane lipoproteins lnt - - ko:K03820 - - - - ko00000,ko01000 - GT2 - CN_hydrolase k59_470740_1 335543.Sfum_0290 1.88e-45 171.0 COG0744@1|root,COG0744@2|Bacteria,1QTST@1224|Proteobacteria,42Q00@68525|delta/epsilon subdivisions,2WJEM@28221|Deltaproteobacteria,2MSIQ@213462|Syntrophobacterales 28221|Deltaproteobacteria M Transglycosylase mrcB - 2.4.1.129,3.4.16.4 ko:K05365 ko00550,map00550 - R04519 RC00005,RC00049 ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 - Transgly,Transpeptidase,UB2H k59_1713602_1 85643.Tmz1t_0782 6.23e-51 175.0 COG0823@1|root,COG0823@2|Bacteria,1MV09@1224|Proteobacteria,2VH9R@28216|Betaproteobacteria,2KUUQ@206389|Rhodocyclales 206389|Rhodocyclales U Involved in the tonB-independent uptake of proteins tolB - - ko:K03641 - - - - ko00000,ko02000 2.C.1.2 - - PD40,TolB_N k59_1713602_2 582744.Msip34_2398 1.4e-05 48.1 COG2885@1|root,COG2885@2|Bacteria,1MZTV@1224|Proteobacteria,2VSP6@28216|Betaproteobacteria,2KMV3@206350|Nitrosomonadales 206350|Nitrosomonadales M Belongs to the ompA family - - - ko:K03640 - - - - ko00000,ko02000 2.C.1.2 - - OmpA k59_1205288_1 1088721.NSU_2475 1.44e-84 256.0 COG1376@1|root,COG1376@2|Bacteria,1RKB2@1224|Proteobacteria,2UAA8@28211|Alphaproteobacteria,2K57T@204457|Sphingomonadales 204457|Sphingomonadales S L,D-transpeptidase catalytic domain - - - - - - - - - - - - YkuD_2 k59_1318669_1 498211.CJA_2064 2.21e-63 216.0 COG1138@1|root,COG1138@2|Bacteria,1MUQS@1224|Proteobacteria,1RMY5@1236|Gammaproteobacteria,1FGHC@10|Cellvibrio 1236|Gammaproteobacteria O Cytochrome c-type biogenesis protein CcmF C-terminal ccmF GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016021,GO:0016043,GO:0017003,GO:0017004,GO:0017006,GO:0018063,GO:0019538,GO:0020037,GO:0022607,GO:0031224,GO:0031226,GO:0034622,GO:0036211,GO:0043170,GO:0043412,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0046906,GO:0048037,GO:0065003,GO:0071704,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564 - ko:K02198 - - - - ko00000,ko02000 9.B.14.1 - - CcmF_C,Cytochrom_C_asm k59_1318672_1 457425.XNR_4167 1.15e-54 188.0 COG0436@1|root,COG0436@2|Bacteria,2I9CX@201174|Actinobacteria 201174|Actinobacteria E Aminotransferase class I and II - - 4.1.1.12 ko:K09758 ko00250,ko00270,ko01100,ko01230,map00250,map00270,map01100,map01230 - R00397,R00863 RC00282,RC00399,RC00400 ko00000,ko00001,ko01000 - - - Aminotran_1_2 k59_978367_1 314287.GB2207_07846 7.51e-84 259.0 COG0001@1|root,COG0001@2|Bacteria,1MUY5@1224|Proteobacteria,1RM7N@1236|Gammaproteobacteria,1J53B@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Aminotransferase hemL GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006725,GO:0006778,GO:0006779,GO:0006782,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016853,GO:0016866,GO:0016869,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042286,GO:0042440,GO:0042802,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046483,GO:0046501,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 5.4.3.8 ko:K01845 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R02272 RC00677 ko00000,ko00001,ko00002,ko01000,ko01007 - - iUMNK88_1353.UMNK88_158 Aminotran_3 k59_1375311_1 1248760.ANFZ01000014_gene2153 1.88e-123 360.0 COG4948@1|root,COG4948@2|Bacteria,1MURK@1224|Proteobacteria,2TV84@28211|Alphaproteobacteria,2JZUU@204457|Sphingomonadales 204457|Sphingomonadales M Belongs to the mandelate racemase muconate lactonizing enzyme family - GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005975,GO:0008150,GO:0008152,GO:0008927,GO:0009056,GO:0016052,GO:0016829,GO:0016835,GO:0016836,GO:0043167,GO:0043169,GO:0044238,GO:0046872,GO:0071704,GO:1901575 4.2.1.8 ko:K08323 ko00040,ko01100,map00040,map01100 M00061 R05606 RC00543 ko00000,ko00001,ko00002,ko01000 - - - MR_MLE_C,MR_MLE_N k59_1375311_2 158500.BV97_02791 1.35e-57 188.0 COG0524@1|root,COG0524@2|Bacteria,1MVG2@1224|Proteobacteria,2TSDV@28211|Alphaproteobacteria,2K37P@204457|Sphingomonadales 204457|Sphingomonadales G 2-dehydro-3-deoxygluconokinase - - 2.7.1.45 ko:K00874 ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200 M00061,M00308,M00631 R01541 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - PfkB k59_131971_1 1313172.YM304_28250 5.63e-54 180.0 COG0842@1|root,COG0842@2|Bacteria,2GN6S@201174|Actinobacteria 201174|Actinobacteria V transport, permease protein - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane k59_1488449_1 15368.BRADI3G42910.1 6.06e-31 124.0 COG3914@1|root,KOG4626@2759|Eukaryota,37IV9@33090|Viridiplantae,3G9DX@35493|Streptophyta,3KPD8@4447|Liliopsida,3I3SN@38820|Poales 35493|Streptophyta GOT gibberellic acid mediated signaling pathway SPY GO:0001101,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005829,GO:0007154,GO:0007165,GO:0008150,GO:0008194,GO:0008375,GO:0009719,GO:0009725,GO:0009735,GO:0009736,GO:0009739,GO:0009740,GO:0009755,GO:0009937,GO:0009938,GO:0009966,GO:0009968,GO:0009987,GO:0010033,GO:0010476,GO:0010646,GO:0010648,GO:0016262,GO:0016740,GO:0016757,GO:0016758,GO:0019222,GO:0023051,GO:0023052,GO:0023057,GO:0031323,GO:0032870,GO:0033993,GO:0042221,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464,GO:0048519,GO:0048523,GO:0048583,GO:0048585,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0070887,GO:0071229,GO:0071310,GO:0071368,GO:0071370,GO:0071396,GO:0071495,GO:0140096,GO:1901700,GO:1901701,GO:2000377 - - - - - - - - - - Glyco_transf_41,TPR_1,TPR_10,TPR_16,TPR_7,TPR_8 k59_526649_1 1229909.NSED_03580 2.09e-55 181.0 COG0063@1|root,arCOG00018@2157|Archaea,41S8I@651137|Thaumarchaeota 651137|Thaumarchaeota G Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration nnrD - 4.2.1.136 ko:K17758 - - - - ko00000,ko01000 - - - Carb_kinase k59_810385_1 1122137.AQXF01000004_gene1718 2.9e-66 206.0 COG0122@1|root,COG0122@2|Bacteria,1MX9C@1224|Proteobacteria,2TVJ7@28211|Alphaproteobacteria 28211|Alphaproteobacteria L 3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase alkA - 3.2.2.21 ko:K01247 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - HhH-GPD k59_810385_2 1122137.AQXF01000004_gene1717 8.67e-25 97.1 COG3453@1|root,COG3453@2|Bacteria,1N9AF@1224|Proteobacteria,2UD2M@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Protein conserved in bacteria - - - - - - - - - - - - DUF442 k59_810389_1 1499967.BAYZ01000003_gene5836 1.92e-11 66.2 COG0457@1|root,COG3577@1|root,COG0457@2|Bacteria,COG3577@2|Bacteria 2|Bacteria S aspartic-type endopeptidase activity - - - ko:K06985 ko04112,map04112 - - - ko00000,ko00001 - - - Asp_protease_2,TPR_19,gag-asp_proteas k59_810389_2 1121861.KB899919_gene2681 4.87e-07 52.8 COG1360@1|root,COG1360@2|Bacteria,1MU4S@1224|Proteobacteria,2TQKZ@28211|Alphaproteobacteria,2JPRZ@204441|Rhodospirillales 204441|Rhodospirillales N flagellar motor protein - - - ko:K02557 ko02030,ko02040,map02030,map02040 - - - ko00000,ko00001,ko02000,ko02035 1.A.30.1 - - OmpA k59_1488454_1 158500.BV97_01589 1.04e-46 156.0 COG0084@1|root,COG0084@2|Bacteria,1MUC0@1224|Proteobacteria,2TS88@28211|Alphaproteobacteria,2K0X6@204457|Sphingomonadales 204457|Sphingomonadales L LuxR family transcriptional regulator - - - ko:K03424 - - - - ko00000,ko01000 - - - TatD_DNase k59_1488454_2 702113.PP1Y_AT26008 2.3e-83 262.0 COG0143@1|root,COG0143@2|Bacteria,1MUBY@1224|Proteobacteria,2TQKA@28211|Alphaproteobacteria,2K0VF@204457|Sphingomonadales 204457|Sphingomonadales J Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation metG - 6.1.1.10 ko:K01874 ko00450,ko00970,map00450,map00970 M00359,M00360 R03659,R04773 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,tRNA-synt_1g k59_1148497_1 765914.ThisiDRAFT_1157 2.49e-133 417.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1WW0R@135613|Chromatiales 135613|Chromatiales V Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family - - - ko:K18138 ko01501,ko01503,map01501,map01503 M00647,M00699,M00718 - - ko00000,ko00001,ko00002,ko01504,ko02000 2.A.6.2 - - ACR_tran k59_1488468_1 1279017.AQYJ01000022_gene2740 2.54e-70 220.0 COG3219@1|root,COG3219@2|Bacteria,1R8C9@1224|Proteobacteria,1S23S@1236|Gammaproteobacteria,4673F@72275|Alteromonadaceae 1236|Gammaproteobacteria S protein conserved in bacteria - - - ko:K09929 - - - - ko00000 - - - DUF2063 k59_1488468_2 1121374.KB891590_gene1691 3.74e-79 244.0 COG3220@1|root,COG3220@2|Bacteria,1MURE@1224|Proteobacteria,1RQ9H@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Belongs to the UPF0276 family - - - ko:K09930 - - - - ko00000 - - - DUF692 k59_358516_1 331869.BAL199_14110 1.88e-51 180.0 COG5421@1|root,COG5421@2|Bacteria,1R3NX@1224|Proteobacteria,2U9E7@28211|Alphaproteobacteria 28211|Alphaproteobacteria L PFAM transposase, IS4 family protein - - - - - - - - - - - - DDE_Tnp_1 k59_696788_2 446469.Sked_30300 5.34e-11 64.7 COG0030@1|root,COG0030@2|Bacteria,2GKBT@201174|Actinobacteria 201174|Actinobacteria J Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits ksgA GO:0000154,GO:0000179,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016433,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.182 ko:K02528 - - R10716 RC00003,RC03257 ko00000,ko01000,ko03009 - - - RrnaAD k59_1092183_1 1384054.N790_09205 1.88e-05 47.8 2CKCT@1|root,32SC5@2|Bacteria,1N1BJ@1224|Proteobacteria,1T6U5@1236|Gammaproteobacteria,1X85I@135614|Xanthomonadales 135614|Xanthomonadales - - - - - - - - - - - - - - - k59_1092183_2 1122604.JONR01000007_gene2879 1.37e-14 72.4 COG1595@1|root,COG1595@2|Bacteria,1RI1M@1224|Proteobacteria,1S780@1236|Gammaproteobacteria,1X678@135614|Xanthomonadales 135614|Xanthomonadales K Belongs to the sigma-70 factor family. ECF subfamily - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 k59_244663_1 1415754.JQMK01000002_gene3084 9.49e-13 68.6 COG1502@1|root,COG1502@2|Bacteria,1MXA6@1224|Proteobacteria,1RZZ7@1236|Gammaproteobacteria,469BP@72275|Alteromonadaceae 1236|Gammaproteobacteria I COG1502 Phosphatidylserine phosphatidylglycerophosphate cardiolipi n synthases and related enzymes - - - - - - - - - - - - PLDc_2 k59_244663_2 292459.STH1241 1.75e-10 63.5 COG1734@1|root,COG1734@2|Bacteria,1V6MF@1239|Firmicutes,24K3N@186801|Clostridia 186801|Clostridia T TIGRFAM Sporulation protein YteA - - - - - - - - - - - - zf-dskA_traR k59_696790_1 935567.JAES01000028_gene2686 9.01e-18 80.1 COG2360@1|root,COG2360@2|Bacteria,1R9W8@1224|Proteobacteria,1S1ZB@1236|Gammaproteobacteria,1X4A3@135614|Xanthomonadales 135614|Xanthomonadales O Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine aat GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008914,GO:0016740,GO:0016746,GO:0016755,GO:0044424,GO:0044464,GO:0140096 2.3.2.6 ko:K00684 - - R03813,R11443,R11444 RC00055,RC00064 ko00000,ko01000 - - - Leu_Phe_trans k59_696790_2 1234364.AMSF01000016_gene1559 1.22e-51 172.0 COG0492@1|root,COG0492@2|Bacteria,1MV15@1224|Proteobacteria,1RMEX@1236|Gammaproteobacteria,1X3Y1@135614|Xanthomonadales 135614|Xanthomonadales O Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family trxB - 1.8.1.9 ko:K00384 ko00450,map00450 - R02016,R03596,R09372 RC00013,RC02518,RC02873 ko00000,ko00001,ko01000 - - - Pyr_redox_2 k59_302172_1 1380394.JADL01000011_gene3850 6.82e-33 132.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,2TQR7@28211|Alphaproteobacteria,2JQ44@204441|Rhodospirillales 204441|Rhodospirillales T methyl-accepting chemotaxis protein - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - HAMP,MCPsignal,sCache_2 k59_1036958_1 1121935.AQXX01000131_gene2792 1.73e-26 106.0 COG0824@1|root,COG0824@2|Bacteria,1R6A6@1224|Proteobacteria 1224|Proteobacteria S Thioesterase - - - - - - - - - - - - - k59_696815_1 1117647.M5M_17960 3.22e-11 62.8 COG0842@1|root,COG0842@2|Bacteria,1QTBE@1224|Proteobacteria,1RNG9@1236|Gammaproteobacteria,1J4E1@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria V ABC-2 family transporter protein - - - ko:K01992 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC2_membrane,ABC2_membrane_3 k59_696815_2 997346.HMPREF9374_2943 4.32e-20 90.9 COG1131@1|root,COG1131@2|Bacteria,1TPMQ@1239|Firmicutes,4HA8K@91061|Bacilli,27CJT@186824|Thermoactinomycetaceae 91061|Bacilli V AAA domain, putative AbiEii toxin, Type IV TA system - - - ko:K01990,ko:K11050 ko02010,map02010 M00254,M00298 - - ko00000,ko00001,ko00002,ko02000 3.A.1,3.A.1.130 - - ABC_tran k59_867233_2 452637.Oter_2165 3.53e-45 156.0 COG1893@1|root,COG1893@2|Bacteria 2|Bacteria H 2-dehydropantoate 2-reductase activity panE GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006573,GO:0006575,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008677,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0072330,GO:1901564,GO:1901566,GO:1901576,GO:1901605 1.1.1.169 ko:K00077 ko00770,ko01100,ko01110,map00770,map01100,map01110 M00119 R02472 RC00726 ko00000,ko00001,ko00002,ko01000 - - - ApbA,ApbA_C k59_640547_1 1192868.CAIU01000008_gene1042 3.28e-41 152.0 COG1502@1|root,COG1502@2|Bacteria,1MWUW@1224|Proteobacteria,2TUW3@28211|Alphaproteobacteria,43ICQ@69277|Phyllobacteriaceae 28211|Alphaproteobacteria I PFAM phospholipase D cls - - ko:K06131 ko00564,ko01100,map00564,map01100 - R07390 RC00017 ko00000,ko00001,ko01000 - - - PLDc_2,PLDc_N k59_1318715_1 1229909.NSED_00655 1.3e-66 211.0 COG0294@1|root,arCOG02817@2157|Archaea,41SGK@651137|Thaumarchaeota 651137|Thaumarchaeota H Pterin binding enzyme - - 2.5.1.15 ko:K00796 ko00790,ko01100,map00790,map01100 M00126,M00841 R03066,R03067 RC00121,RC00842 ko00000,ko00001,ko00002,ko01000 - - - Pterin_bind k59_470820_1 1183438.GKIL_3395 2.66e-75 253.0 COG0515@1|root,COG0515@2|Bacteria,1G3GV@1117|Cyanobacteria 1183438.GKIL_3395|- T serine threonine protein kinase - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - - k59_19175_1 713586.KB900536_gene2081 1.49e-11 69.3 COG4942@1|root,COG4942@2|Bacteria,1MY3E@1224|Proteobacteria,1RPQP@1236|Gammaproteobacteria,1WX4I@135613|Chromatiales 135613|Chromatiales D PFAM peptidase - - - - - - - - - - - - Peptidase_M23 k59_414264_1 1122185.N792_06025 2.09e-07 51.6 COG0320@1|root,COG0320@2|Bacteria,1MVRD@1224|Proteobacteria,1RMAT@1236|Gammaproteobacteria,1X4X5@135614|Xanthomonadales 135614|Xanthomonadales H Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives - - 2.8.1.8 ko:K03644 ko00785,ko01100,map00785,map01100 - R07767,R07768 RC01978 ko00000,ko00001,ko01000 - - - LIAS_N,Radical_SAM k59_414264_2 1149133.ppKF707_3943 2.94e-91 282.0 COG0616@1|root,COG0616@2|Bacteria,1MUXE@1224|Proteobacteria,1RNN9@1236|Gammaproteobacteria,1YEND@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria OU Peptidase family S49 N-terminal sohB GO:0005575,GO:0005623,GO:0005886,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0016020,GO:0019538,GO:0043170,GO:0044238,GO:0044464,GO:0071704,GO:0071944,GO:1901564 - ko:K04774 - - - - ko00000,ko01000,ko01002 - - - Peptidase_S49,Peptidase_S49_N k59_1658440_2 1229909.NSED_08025 3.18e-126 365.0 COG0367@1|root,arCOG00071@2157|Archaea,41SIX@651137|Thaumarchaeota 651137|Thaumarchaeota E Asparagine synthase - - 6.3.5.4 ko:K01953 ko00250,ko01100,ko01110,map00250,map01100,map01110 - R00578 RC00010 ko00000,ko00001,ko01000,ko01002 - - - Asn_synthase k59_1037462_1 439375.Oant_3525 2.41e-85 260.0 COG2307@1|root,COG2307@2|Bacteria,1MVZK@1224|Proteobacteria,2TQUM@28211|Alphaproteobacteria,1J3YA@118882|Brucellaceae 28211|Alphaproteobacteria S A predicted alpha-helical domain with a conserved ER motif. MA20_32425 - - - - - - - - - - - Alpha-E k59_302572_2 436308.Nmar_0876 2.28e-54 172.0 COG0640@1|root,arCOG03067@2157|Archaea,41T62@651137|Thaumarchaeota 651137|Thaumarchaeota K transcriptional regulators - - - - - - - - - - - - - k59_76984_1 243159.AFE_2876 3.66e-13 68.2 COG2210@1|root,COG2210@2|Bacteria,1QCK1@1224|Proteobacteria,1S4I3@1236|Gammaproteobacteria,2NE4V@225057|Acidithiobacillales 225057|Acidithiobacillales S DsrE/DsrF/DrsH-like family - - - - - - - - - - - - DrsE_2 k59_76984_2 2340.JV46_18900 2.02e-20 84.0 COG0607@1|root,COG0607@2|Bacteria,1REHH@1224|Proteobacteria,1S343@1236|Gammaproteobacteria 1236|Gammaproteobacteria P Pfam Rhodanese-like - - - - - - - - - - - - Rhodanese k59_697318_1 1137281.D778_01772 1.29e-37 138.0 COG1012@1|root,COG1012@2|Bacteria,4NFPJ@976|Bacteroidetes,1HX3I@117743|Flavobacteriia 976|Bacteroidetes C Belongs to the aldehyde dehydrogenase family pcd - 1.2.1.3 ko:K00128 ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130 M00135 R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146 RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_697318_2 983544.Lacal_0910 7.53e-81 251.0 COG1446@1|root,COG1446@2|Bacteria,4NF1U@976|Bacteroidetes,1HXC4@117743|Flavobacteriia 976|Bacteroidetes E asparaginase - - 3.4.19.5 ko:K13051 - - - - ko00000,ko01000,ko01002 - - - Asparaginase_2 k59_132529_1 713586.KB900536_gene2234 8.83e-71 235.0 COG0550@1|root,COG0550@2|Bacteria,1MUFZ@1224|Proteobacteria,1RNZ2@1236|Gammaproteobacteria,1WWWP@135613|Chromatiales 135613|Chromatiales L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone topA - 5.99.1.2 ko:K03168 - - - - ko00000,ko01000,ko03032,ko03400 - - - Topo_Zn_Ribbon,Topoisom_bac,Toprim,Toprim_C_rpt,zf-C4_Topoisom k59_1375901_1 1207058.L53_01355 1.63e-21 90.5 COG3832@1|root,COG3832@2|Bacteria,1Q4JU@1224|Proteobacteria,2V6I0@28211|Alphaproteobacteria,43ZSQ@69657|Hyphomonadaceae 28211|Alphaproteobacteria S Activator of Hsp90 ATPase homolog 1-like protein - - - - - - - - - - - - AHSA1 k59_1545140_1 1122137.AQXF01000003_gene2089 1.33e-64 218.0 COG1629@1|root,COG1629@2|Bacteria,1QUTW@1224|Proteobacteria,2TW7F@28211|Alphaproteobacteria 28211|Alphaproteobacteria P receptor - - - - - - - - - - - - Plug,TonB_dep_Rec k59_1149054_1 686340.Metal_3837 5.84e-53 180.0 COG1459@1|root,COG1459@2|Bacteria,1MV4U@1224|Proteobacteria,1RQ86@1236|Gammaproteobacteria,1XEBQ@135618|Methylococcales 135618|Methylococcales U type II secretion system - - - ko:K02455 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - T2SSF k59_1092639_1 1437882.AZRU01000080_gene3976 3.72e-64 209.0 COG0635@1|root,COG0635@2|Bacteria,1MU76@1224|Proteobacteria,1RN6I@1236|Gammaproteobacteria,1YEBI@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria H Involved in the biosynthesis of porphyrin-containing compound yggW GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 - - - - - - - - - - HemN_C,Radical_SAM k59_978909_1 1123253.AUBD01000008_gene555 6.38e-88 292.0 COG5276@1|root,COG5276@2|Bacteria,1R66X@1224|Proteobacteria,1S05Q@1236|Gammaproteobacteria,1X429@135614|Xanthomonadales 135614|Xanthomonadales S LVIVD repeat - - - - - - - - - - - - LVIVD k59_978909_2 1535422.ND16A_2982 5.8e-45 162.0 COG3827@1|root,COG3827@2|Bacteria,1QQR0@1224|Proteobacteria,1S068@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_245188_1 626887.J057_18035 3.21e-96 290.0 COG0502@1|root,COG0502@2|Bacteria,1MVFF@1224|Proteobacteria,1RMEQ@1236|Gammaproteobacteria,46540@72275|Alteromonadaceae 1236|Gammaproteobacteria H Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism bioB GO:0003674,GO:0003824,GO:0004076,GO:0005488,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016740,GO:0016782,GO:0016783,GO:0017144,GO:0018130,GO:0019752,GO:0032787,GO:0034641,GO:0042364,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051537,GO:0051539,GO:0051540,GO:0070283,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.8.1.6 ko:K01012 ko00780,ko01100,map00780,map01100 M00123,M00573,M00577 R01078 RC00441 ko00000,ko00001,ko00002,ko01000 - - iZ_1308.Z0994 BATS,Radical_SAM k59_1149072_1 1122194.AUHU01000003_gene2145 6.88e-73 234.0 COG1030@1|root,COG1030@2|Bacteria,1MUJN@1224|Proteobacteria,1RN3U@1236|Gammaproteobacteria,465X3@72275|Alteromonadaceae 1224|Proteobacteria O COG1030 Membrane-bound serine protease (ClpP class) - - - ko:K07403 - - - - ko00000 - - - NfeD,SDH_sah k59_245191_1 1248917.ANFX01000037_gene2105 7.45e-59 201.0 COG0642@1|root,COG0642@2|Bacteria,1RDQ3@1224|Proteobacteria,2U7I3@28211|Alphaproteobacteria,2KE9H@204457|Sphingomonadales 204457|Sphingomonadales T Histidine kinase - - - - - - - - - - - - HisKA k59_1431495_1 931626.Awo_c17510 3.79e-34 126.0 COG1366@1|root,COG3852@1|root,COG1366@2|Bacteria,COG3852@2|Bacteria,1UGQT@1239|Firmicutes,24HHN@186801|Clostridia 186801|Clostridia T transporter antisigma-factor antagonist STAS - - - ko:K17763 - - - - ko00000,ko03021 - - - RsbRD_N,STAS k59_1092655_1 1122604.JONR01000065_gene3576 6.61e-87 286.0 COG0085@1|root,COG0085@2|Bacteria,1MUC4@1224|Proteobacteria,1RMK0@1236|Gammaproteobacteria,1X3ME@135614|Xanthomonadales 135614|Xanthomonadales K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoB GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234 2.7.7.6 ko:K03043 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00183 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400 - - - RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7 k59_697354_1 1415778.JQMM01000001_gene1621 2.02e-108 324.0 COG0626@1|root,COG0626@2|Bacteria,1MU57@1224|Proteobacteria,1RMCV@1236|Gammaproteobacteria,1J4WT@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Catalyzes the formation of L-homocysteine from O- succinyl-L-homoserine (OSHS) and hydrogen sulfide metZ - - ko:K10764 ko00270,ko00920,ko01100,map00270,map00920,map01100 - R01288 RC00020,RC02848 ko00000,ko00001,ko01000 - - - Cys_Met_Meta_PP k59_584221_1 991905.SL003B_0940 4.27e-22 94.7 COG0564@1|root,COG0564@2|Bacteria,1MUBN@1224|Proteobacteria,2TSBK@28211|Alphaproteobacteria,4BP8R@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria J Responsible for synthesis of pseudouridine from uracil rluD GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360 5.4.99.23 ko:K06180 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2,S4 k59_584221_2 1532557.JL37_07170 2.62e-43 150.0 COG1496@1|root,COG1496@2|Bacteria,1MW2H@1224|Proteobacteria,2VKD4@28216|Betaproteobacteria,3T3KR@506|Alcaligenaceae 28216|Betaproteobacteria S Belongs to the multicopper oxidase YfiH RL5 family yfiH - - ko:K05810 - - - - ko00000,ko01000 - - - Cu-oxidase_4 k59_1770768_1 414684.RC1_3819 3.03e-27 114.0 COG0845@1|root,COG0845@2|Bacteria,1N97Q@1224|Proteobacteria,2U1HJ@28211|Alphaproteobacteria,2JPCD@204441|Rhodospirillales 204441|Rhodospirillales M Evidence 4 Homologs of previously reported genes of - - - - - - - - - - - - Biotin_lipoyl_2,HlyD_3 k59_359128_1 1232410.KI421413_gene685 4.26e-31 113.0 COG1327@1|root,COG1327@2|Bacteria,1RE7V@1224|Proteobacteria,42SJP@68525|delta/epsilon subdivisions,2WPK0@28221|Deltaproteobacteria,43SIP@69541|Desulfuromonadales 28221|Deltaproteobacteria K ATP cone domain nrdR - - ko:K07738 - - - - ko00000,ko03000 - - - ATP-cone k59_359128_2 1120972.AUMH01000007_gene1741 2.9e-148 431.0 COG0304@1|root,COG0304@2|Bacteria,1TPA7@1239|Firmicutes,4H9SD@91061|Bacilli,2786J@186823|Alicyclobacillaceae 91061|Bacilli I Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP fabF_1 - 2.3.1.179 ko:K09458 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119 RC00039,RC02728,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Ketoacyl-synt_C,ketoacyl-synt k59_1770771_1 1115632.JAFW01000001_gene3063 1.39e-10 61.2 COG2273@1|root,COG2273@2|Bacteria,2GJQP@201174|Actinobacteria,1WBJ9@1268|Micrococcaceae 201174|Actinobacteria G Glycosyl hydrolases family 16 - - - - - - - - - - - - Glyco_hydro_16,RicinB_lectin_2,Ricin_B_lectin k59_1770771_2 1122194.AUHU01000007_gene272 1.32e-41 150.0 COG3250@1|root,COG3250@2|Bacteria,1R8R6@1224|Proteobacteria,1RZM7@1236|Gammaproteobacteria,4660T@72275|Alteromonadaceae 1236|Gammaproteobacteria G Glycosyl hydrolases family 2, TIM barrel domain - - - - - - - - - - - - Glyco_hydro_2_C k59_359129_1 1131553.JIBI01000026_gene62 1.06e-44 157.0 COG2267@1|root,COG2267@2|Bacteria,1QXHW@1224|Proteobacteria,2W9K4@28216|Betaproteobacteria,372K0@32003|Nitrosomonadales 28216|Betaproteobacteria I alpha/beta hydrolase fold - - - - - - - - - - - - Abhydrolase_6 k59_414712_1 105559.Nwat_0947 1.11e-47 167.0 2C6D0@1|root,31F07@2|Bacteria,1RHBN@1224|Proteobacteria,1S7HH@1236|Gammaproteobacteria,1WX2B@135613|Chromatiales 135613|Chromatiales S Domain of unknown function (DUF4340) - - - - - - - - - - - - DUF4340 k59_1037498_1 1122614.JHZF01000013_gene3881 5.64e-26 107.0 COG1729@1|root,COG1729@2|Bacteria,1MUSV@1224|Proteobacteria,2U6ZQ@28211|Alphaproteobacteria,2PCMA@252301|Oceanicola 28211|Alphaproteobacteria D Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division cpoB - - - - - - - - - - - TPR_16,TPR_6,TolA_bind_tri k59_527213_1 1248916.ANFY01000003_gene902 9.36e-31 119.0 COG0055@1|root,COG0055@2|Bacteria,1MUFU@1224|Proteobacteria,2TRGP@28211|Alphaproteobacteria,2K03H@204457|Sphingomonadales 204457|Sphingomonadales C Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits atpD - 3.6.3.14 ko:K02112 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - - ATP-synt_ab,ATP-synt_ab_N k59_527213_2 1122137.AQXF01000003_gene1925 2.56e-65 201.0 COG0355@1|root,COG0355@2|Bacteria,1RHE4@1224|Proteobacteria,2UBXX@28211|Alphaproteobacteria 28211|Alphaproteobacteria C Produces ATP from ADP in the presence of a proton gradient across the membrane atpC GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016469,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0045259,GO:0045261,GO:0046034,GO:0046390,GO:0046483,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - ko:K02113,ko:K02114 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt_DE_N k59_1431513_1 1096930.L284_05895 2.07e-05 44.3 COG0140@1|root,COG0140@2|Bacteria,1MZEE@1224|Proteobacteria,2UBU3@28211|Alphaproteobacteria,2K5ZV@204457|Sphingomonadales 204457|Sphingomonadales E Phosphoribosyl-ATP hisE - 3.6.1.31 ko:K01523 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04035 RC00002 ko00000,ko00001,ko00002,ko01000 - - - PRA-PH k59_310972_3 1209072.ALBT01000011_gene3149 1.45e-68 216.0 COG0113@1|root,COG0113@2|Bacteria,1MWMW@1224|Proteobacteria,1RP6Q@1236|Gammaproteobacteria,1FH5J@10|Cellvibrio 1236|Gammaproteobacteria H Delta-aminolevulinic acid dehydratase hemB GO:0000287,GO:0003674,GO:0003824,GO:0004655,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009987,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.2.1.24 ko:K01698 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R00036 RC00918,RC01781 ko00000,ko00001,ko00002,ko01000,ko04147 - - iECABU_c1320.ECABU_c04500,iEcSMS35_1347.EcSMS35_0398,iJN746.PP_2913,ic_1306.c0477 ALAD k59_1045901_1 1238450.VIBNISOn1_710036 2.41e-40 149.0 COG0323@1|root,COG0642@1|root,COG0323@2|Bacteria,COG0642@2|Bacteria,1QWFS@1224|Proteobacteria,1T2V7@1236|Gammaproteobacteria,1Y380@135623|Vibrionales 135623|Vibrionales T Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - HATPase_c,HATPase_c_3 k59_421671_1 1095769.CAHF01000013_gene3306 4.44e-42 148.0 COG3655@1|root,COG3655@2|Bacteria,1RBPK@1224|Proteobacteria,2VIYU@28216|Betaproteobacteria,475EJ@75682|Oxalobacteraceae 28216|Betaproteobacteria K Cro/C1-type HTH DNA-binding domain - - - - - - - - - - - - HTH_26 k59_85468_1 765913.ThidrDRAFT_1193 1.05e-47 161.0 COG2095@1|root,COG2095@2|Bacteria,1MX5T@1224|Proteobacteria,1RPZ3@1236|Gammaproteobacteria,1WYZD@135613|Chromatiales 135613|Chromatiales U PFAM Multiple antibiotic resistance (MarC)-related - - - ko:K05595 - - - - ko00000,ko02000 2.A.95.1 - - MarC k59_1437560_2 626887.J057_02520 8.01e-17 79.3 COG3655@1|root,COG3655@2|Bacteria,1RBPK@1224|Proteobacteria,1S22Y@1236|Gammaproteobacteria,4657A@72275|Alteromonadaceae 1236|Gammaproteobacteria K Cro/C1-type HTH DNA-binding domain - - - - - - - - - - - - HTH_26 k59_310992_1 1229909.NSED_02965 5.61e-29 106.0 arCOG07473@1|root,arCOG07473@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_1045919_1 1122137.AQXF01000006_gene760 1.2e-15 75.9 COG0460@1|root,COG0460@2|Bacteria,1MUDC@1224|Proteobacteria,2TQWS@28211|Alphaproteobacteria 28211|Alphaproteobacteria E homoserine dehydrogenase hom GO:0003674,GO:0003824,GO:0004412,GO:0006082,GO:0006520,GO:0006566,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009088,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.1.1.3 ko:K00003 ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230 M00017,M00018 R01773,R01775 RC00087 ko00000,ko00001,ko00002,ko01000 - - - ACT,Homoserine_dh,NAD_binding_3 k59_1045919_2 629773.AORY01000016_gene3040 2.08e-108 321.0 COG1494@1|root,COG1494@2|Bacteria,1MUB1@1224|Proteobacteria,2TSPE@28211|Alphaproteobacteria,2JZUH@204457|Sphingomonadales 204457|Sphingomonadales G in Escherichia coli this protein forms a dimer and binds manganese glpX - 3.1.3.11,3.1.3.37 ko:K11532 ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200 M00003,M00165,M00167 R00762,R01845,R04780 RC00017 ko00000,ko00001,ko00002,ko01000 - - - FBPase_glpX k59_929340_1 555793.WSK_1183 1.71e-56 198.0 COG2911@1|root,COG2911@2|Bacteria,1MUVD@1224|Proteobacteria,2TR45@28211|Alphaproteobacteria,2K0C4@204457|Sphingomonadales 204457|Sphingomonadales S protein conserved in bacteria - - - ko:K09800 - - - - ko00000,ko02000 - - - TamB k59_1610070_1 326297.Sama_3412 1.88e-38 147.0 COG4773@1|root,COG4773@2|Bacteria,1QTT0@1224|Proteobacteria,1RNBT@1236|Gammaproteobacteria,2QBTK@267890|Shewanellaceae 1236|Gammaproteobacteria P TonB dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_1554282_1 158500.BV97_02732 1.05e-114 344.0 COG0661@1|root,COG0661@2|Bacteria,1MU1Z@1224|Proteobacteria,2TS87@28211|Alphaproteobacteria,2K1BA@204457|Sphingomonadales 204457|Sphingomonadales S Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis ubiB - - ko:K03688 - - - - ko00000 - - - ABC1 k59_1554282_2 158500.BV97_02733 1.12e-20 87.4 COG0500@1|root,COG2226@2|Bacteria,1MX8I@1224|Proteobacteria,2TRWR@28211|Alphaproteobacteria,2K080@204457|Sphingomonadales 204457|Sphingomonadales H Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2- polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) ubiE - 2.1.1.163,2.1.1.201 ko:K03183 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116,M00117 R04990,R04993,R06859,R08774,R09736 RC00003,RC01253,RC01662 ko00000,ko00001,ko00002,ko01000 - - - Ubie_methyltran k59_1214094_1 1134474.O59_000991 1.74e-54 181.0 COG1196@1|root,COG1196@2|Bacteria,1NGHR@1224|Proteobacteria,1T3FE@1236|Gammaproteobacteria,1FI67@10|Cellvibrio 1236|Gammaproteobacteria D Protein of unknown function (DUF3450) - - - - - - - - - - - - DUF3450 k59_29527_1 1123487.KB892834_gene2856 1.9e-111 329.0 COG0216@1|root,COG0216@2|Bacteria,1MV28@1224|Proteobacteria,2VJKV@28216|Betaproteobacteria,2KV7M@206389|Rhodocyclales 206389|Rhodocyclales J Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA prfA - - ko:K02835 - - - - ko00000,ko03012 - - - PCRF,RF-1 k59_1269088_1 247634.GPB2148_80 3.02e-82 256.0 COG0738@1|root,COG0738@2|Bacteria,1R3UK@1224|Proteobacteria,1RZ2I@1236|Gammaproteobacteria,1J7JC@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria G Major Facilitator Superfamily - - - - - - - - - - - - MFS_1 k59_1100067_1 1168065.DOK_17710 1.38e-24 101.0 COG3161@1|root,COG3161@2|Bacteria,1N8BF@1224|Proteobacteria,1SDX2@1236|Gammaproteobacteria,1J6IV@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway ubiC GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0008813,GO:0009058,GO:0009108,GO:0009987,GO:0016829,GO:0016830,GO:0016833,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901661,GO:1901663 4.1.3.40 ko:K03181 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00117 R01302 RC00491,RC02148 ko00000,ko00001,ko00002,ko01000 - - iZ_1308.Z5638 Chor_lyase k59_86638_1 568768.CM001975_gene504 3.48e-79 241.0 COG1974@1|root,COG1974@2|Bacteria,1MW80@1224|Proteobacteria,1RMXF@1236|Gammaproteobacteria,2JD8P@204037|Dickeya 1236|Gammaproteobacteria K Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. Binds to the 16 bp palindromic sequence 5'-CTGTATATATATACAG-3'. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair lexA GO:0000976,GO:0001067,GO:0001130,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006282,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009432,GO:0009605,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0009991,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031668,GO:0032774,GO:0032991,GO:0032993,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0042802,GO:0043170,GO:0043565,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045934,GO:0046483,GO:0048519,GO:0048523,GO:0048583,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0051716,GO:0060255,GO:0065007,GO:0071496,GO:0071704,GO:0080090,GO:0080134,GO:0080135,GO:0090304,GO:0097159,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2001020,GO:2001141 3.4.21.88 ko:K01356 - M00729 - - ko00000,ko00002,ko01000,ko01002,ko03400 - - - LexA_DNA_bind,Peptidase_S24 k59_985920_1 1144305.PMI02_05308 5.21e-56 199.0 COG1215@1|root,COG1215@2|Bacteria,1MWF8@1224|Proteobacteria,2TS1X@28211|Alphaproteobacteria,2K1J5@204457|Sphingomonadales 204457|Sphingomonadales M Cellulose synthase - - 2.4.1.12 ko:K00694,ko:K20541 ko00500,ko01100,ko02026,map00500,map01100,map02026 - R02889 RC00005 ko00000,ko00001,ko01000,ko01003,ko02000 4.D.3.1.2,4.D.3.1.5,4.D.3.1.6 GT2 - BcsB,Cellulose_synt,Glycos_transf_2,PilZ k59_369020_1 1122137.AQXF01000002_gene130 5.58e-82 256.0 COG4591@1|root,COG4591@2|Bacteria,1MVV7@1224|Proteobacteria,2TRBX@28211|Alphaproteobacteria 28211|Alphaproteobacteria M lipoprotein releasing system, transmembrane protein, LolC E family' lolC - - ko:K09808 ko02010,map02010 M00255 - - ko00000,ko00001,ko00002,ko02000 3.A.1.125 - - FtsX,MacB_PCD k59_369020_2 1552758.NC00_08040 3.5e-62 201.0 COG1136@1|root,COG1136@2|Bacteria,1MVSQ@1224|Proteobacteria,1RMWK@1236|Gammaproteobacteria,1X2X9@135614|Xanthomonadales 135614|Xanthomonadales V Part of the ABC transporter complex LolCDE involved in the translocation of lolD - - ko:K09810 ko02010,map02010 M00255 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.125 - - ABC_tran k59_706871_1 436308.Nmar_0686 4.13e-87 274.0 COG0018@1|root,arCOG00487@2157|Archaea,41SAI@651137|Thaumarchaeota 651137|Thaumarchaeota J Belongs to the class-I aminoacyl-tRNA synthetase family argS - 6.1.1.19 ko:K01887 ko00970,map00970 M00359,M00360 R03646 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d k59_29530_1 1123037.AUDE01000009_gene1254 7.97e-62 191.0 2B8TT@1|root,3223W@2|Bacteria,4NR6E@976|Bacteroidetes,1I3FY@117743|Flavobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_29530_2 620914.JH621247_gene2950 5.01e-40 145.0 COG1217@1|root,COG1217@2|Bacteria,4NDVM@976|Bacteroidetes,1HY43@117743|Flavobacteriia,2YIFU@290174|Aquimarina 976|Bacteroidetes T Elongation factor G C-terminus typA - - ko:K06207 - - - - ko00000 - - - EFG_C,GTP_EFTU,GTP_EFTU_D2 k59_1555512_1 85643.Tmz1t_1284 6.21e-39 135.0 COG0589@1|root,COG0589@2|Bacteria,1MZ3K@1224|Proteobacteria,2VQAE@28216|Betaproteobacteria,2KW8T@206389|Rhodocyclales 206389|Rhodocyclales T Universal stress protein - - - - - - - - - - - - Usp k59_1498816_1 1449357.JQLK01000001_gene310 1.46e-19 87.0 COG0321@1|root,COG0321@2|Bacteria,1WIJ7@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus H Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate lipB GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009249,GO:0009987,GO:0010467,GO:0018065,GO:0018193,GO:0018205,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0051604,GO:0071704,GO:1901564 2.3.1.181 ko:K03801 ko00785,ko01100,map00785,map01100 - R07766,R07769 RC00039,RC00992,RC02867 ko00000,ko00001,ko01000 - - - BPL_LplA_LipB k59_1498816_2 1382306.JNIM01000001_gene942 4.49e-41 151.0 COG0508@1|root,COG0508@2|Bacteria,2G619@200795|Chloroflexi 200795|Chloroflexi C Catalytic domain of components of various dehydrogenase complexes - - 2.3.1.12 ko:K00627 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200 M00307 R00209,R02569 RC00004,RC02742,RC02857 br01601,ko00000,ko00001,ko00002,ko01000 - - - 2-oxoacid_dh,Biotin_lipoyl,E3_binding k59_1100074_2 452637.Oter_3156 1.12e-06 50.4 COG0577@1|root,COG0577@2|Bacteria,46UW2@74201|Verrucomicrobia 74201|Verrucomicrobia V MacB-like periplasmic core domain - - - - - - - - - - - - FtsX,MacB_PCD k59_478116_1 314266.SKA58_16963 2.64e-112 330.0 COG0847@1|root,COG0847@2|Bacteria,1MXM2@1224|Proteobacteria,2TUYC@28211|Alphaproteobacteria,2K4AV@204457|Sphingomonadales 204457|Sphingomonadales L COG0847 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases - - 2.7.7.7 ko:K02342 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - RNase_T k59_1269098_1 113395.AXAI01000004_gene4352 8.9e-17 82.0 COG0500@1|root,COG2226@2|Bacteria,1PPKI@1224|Proteobacteria,2TRIB@28211|Alphaproteobacteria,3JRP5@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria Q ubiE/COQ5 methyltransferase family MA20_37085 - - - - - - - - - - - Methyltransf_11,Methyltransf_25 k59_141650_1 1121360.AUAQ01000011_gene494 5.5e-23 102.0 COG0770@1|root,COG0770@2|Bacteria,2GK0Y@201174|Actinobacteria,22KRC@1653|Corynebacteriaceae 201174|Actinobacteria M Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein murF GO:0008150,GO:0040007 6.3.2.10 ko:K01929 ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502 - R04573,R04617 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_1157492_1 1415778.JQMM01000001_gene1226 1.12e-28 121.0 COG3419@1|root,COG3419@2|Bacteria,1NUAV@1224|Proteobacteria,1RPV3@1236|Gammaproteobacteria,1J4N1@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria NU COG3419 Tfp pilus assembly protein, tip-associated adhesin PilY1 comC - - ko:K02674 - - - - ko00000,ko02035,ko02044 - - - Neisseria_PilC,VWA_2 k59_1723766_1 228410.NE1937 6.39e-101 300.0 28I53@1|root,2Z88I@2|Bacteria,1NE5N@1224|Proteobacteria,2VZB8@28216|Betaproteobacteria,372HT@32003|Nitrosomonadales 28216|Betaproteobacteria S Protein of unknown function (DUF3750) - - - - - - - - - - - - DUF3750 k59_877360_1 1206731.BAGB01000068_gene7243 1.12e-13 70.9 COG0560@1|root,COG0560@2|Bacteria,2GJVX@201174|Actinobacteria,4FTZ0@85025|Nocardiaceae 201174|Actinobacteria E haloacid dehalogenase-like hydrolase serB GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 - - - - - - - - - - HAD k59_877360_2 1313172.YM304_02880 5.96e-27 110.0 COG0477@1|root,COG2814@2|Bacteria,2GKHG@201174|Actinobacteria,4CNYN@84992|Acidimicrobiia 84992|Acidimicrobiia EGP Transmembrane secretion effector - - - - - - - - - - - - MFS_3 k59_760387_1 314285.KT71_17301 4.09e-56 189.0 COG3203@1|root,COG3203@2|Bacteria,1MX4Q@1224|Proteobacteria,1RY5B@1236|Gammaproteobacteria,1J4WZ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane - - - - - - - - - - - - Porin_2 k59_593654_1 634497.HAH_4444 1.59e-69 235.0 COG0474@1|root,arCOG01578@2157|Archaea,2XT4B@28890|Euryarchaeota,23SFC@183963|Halobacteria 183963|Halobacteria P Cation transporting ATPase, C-terminus - - - - - - - - - - - - Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase k59_1555540_1 983545.Glaag_3546 9.79e-75 248.0 COG0525@1|root,COG0525@2|Bacteria,1MV7B@1224|Proteobacteria,1RNEB@1236|Gammaproteobacteria,465F9@72275|Alteromonadaceae 1236|Gammaproteobacteria J amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner valS GO:0000287,GO:0002161,GO:0003674,GO:0003824,GO:0004812,GO:0004832,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006417,GO:0006418,GO:0006438,GO:0006450,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0016070,GO:0016787,GO:0016788,GO:0016874,GO:0016875,GO:0019222,GO:0019538,GO:0019752,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0034248,GO:0034250,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045727,GO:0045903,GO:0046483,GO:0046872,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0052689,GO:0060255,GO:0061475,GO:0065007,GO:0065008,GO:0071704,GO:0080090,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:2000112 6.1.1.9 ko:K01873 ko00970,map00970 M00359,M00360 R03665 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iECH74115_1262.ECH74115_5779,iECNA114_1301.ECNA114_4481,iECO26_1355.ECO26_5428,iECSP_1301.ECSP_5359,iECs_1301.ECs5235,iG2583_1286.G2583_5088,iJN746.PP_0977,iSBO_1134.SBO_4182,iSSON_1240.SSON_4443,iYL1228.KPN_04663,iZ_1308.Z5870 Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1 k59_930161_1 722419.PH505_di00050 5.27e-160 486.0 COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,1SP6I@1236|Gammaproteobacteria,2Q0R6@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria P Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family czcA - - ko:K15726 - - - - ko00000,ko02000 2.A.6.1.2 - - ACR_tran k59_593663_2 202698.XP_007381906.1 6.96e-07 54.7 COG1028@1|root,KOG0725@2759|Eukaryota,38H5G@33154|Opisthokonta,3NWE0@4751|Fungi,3V039@5204|Basidiomycota,226S9@155619|Agaricomycetes,3H390@355688|Agaricomycetes incertae sedis 4751|Fungi Q Enoyl-(Acyl carrier protein) reductase - - - - - - - - - - - - adh_short_C2 k59_1611113_1 429009.Adeg_1320 9.74e-44 154.0 COG4974@1|root,COG4974@2|Bacteria,1TQRG@1239|Firmicutes,247QQ@186801|Clostridia,42FSH@68295|Thermoanaerobacterales 186801|Clostridia L integrase domain protein SAM domain protein xerC - - ko:K03733,ko:K04763 - - - - ko00000,ko03036 - - - Phage_int_SAM_1,Phage_int_SAM_4,Phage_integrase k59_254343_1 547163.BN979_03755 1.51e-66 223.0 COG0318@1|root,COG0318@2|Bacteria,2GJAA@201174|Actinobacteria,23466@1762|Mycobacteriaceae 201174|Actinobacteria IQ Activates fatty acids by binding to coenzyme A - - - ko:K00666 - - - - ko00000,ko01000,ko01004 - - - AMP-binding,AMP-binding_C k59_593668_1 98439.AJLL01000068_gene1520 1.21e-51 184.0 COG5001@1|root,COG5001@2|Bacteria,1G0SY@1117|Cyanobacteria,1JGRR@1189|Stigonemataceae 1117|Cyanobacteria T Putative diguanylate phosphodiesterase - - - - - - - - - - - - EAL,FHA,GAF,GGDEF,PAS_9 k59_1438434_1 436308.Nmar_0073 6.38e-25 96.3 COG1412@1|root,arCOG04312@2157|Archaea,41SUY@651137|Thaumarchaeota 651137|Thaumarchaeota S Nucleotide binding protein, PINc - - - ko:K07158 - - - - ko00000 - - - Fcf1 k59_1438434_2 1131266.ARWQ01000001_gene1280 5.66e-53 171.0 COG1881@1|root,arCOG04702@2157|Archaea,41T4M@651137|Thaumarchaeota 651137|Thaumarchaeota S Phosphatidylethanolamine-binding protein - - - ko:K06910 - - - - ko00000 - - - PBP k59_1438434_3 1229909.NSED_00075 4.73e-20 80.5 COG2260@1|root,arCOG00906@2157|Archaea,41SUI@651137|Thaumarchaeota 651137|Thaumarchaeota J more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA nop10 - - ko:K11130 ko03008,map03008 M00425 - - ko00000,ko00001,ko00002,ko03009,ko03032 - - - Nop10p k59_369067_1 1157943.KB892705_gene2604 3.27e-20 92.0 COG0024@1|root,COG0024@2|Bacteria,2GKKB@201174|Actinobacteria,232U8@1762|Mycobacteriaceae 201174|Actinobacteria E Methionine aminopeptidase mapA GO:0000096,GO:0003674,GO:0003824,GO:0004177,GO:0005488,GO:0005506,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006464,GO:0006508,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008235,GO:0008237,GO:0008238,GO:0009066,GO:0009987,GO:0010467,GO:0016020,GO:0016151,GO:0016485,GO:0016787,GO:0019538,GO:0019752,GO:0030145,GO:0035551,GO:0036211,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044281,GO:0044464,GO:0046872,GO:0046914,GO:0050897,GO:0051604,GO:0070006,GO:0070011,GO:0070084,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901605 3.4.11.18 ko:K01265 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M24 k59_1611124_1 1123270.ATUR01000006_gene150 6.86e-148 427.0 COG4638@1|root,COG4638@2|Bacteria,1NSC4@1224|Proteobacteria,2UQBE@28211|Alphaproteobacteria,2K2BM@204457|Sphingomonadales 204457|Sphingomonadales P Ring hydroxylating alpha subunit (catalytic domain) - - - - - - - - - - - - Rieske,Ring_hydroxyl_A k59_930189_1 323259.Mhun_1711 9e-31 114.0 COG0432@1|root,arCOG04214@2157|Archaea,2XYW0@28890|Euryarchaeota,2N9WB@224756|Methanomicrobia 224756|Methanomicrobia S Uncharacterised protein family UPF0047 - - - - - - - - - - - - UPF0047 k59_254378_1 869210.Marky_1927 3.09e-50 176.0 COG0076@1|root,COG0076@2|Bacteria,1WKXN@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus E COG0076 Glutamate decarboxylase and related PLP-dependent - - 4.1.1.105,4.1.1.28 ko:K01593 ko00350,ko00360,ko00380,ko00901,ko00950,ko00965,ko01100,ko01110,ko04726,ko04728,ko05030,ko05031,ko05034,map00350,map00360,map00380,map00901,map00950,map00965,map01100,map01110,map04726,map04728,map05030,map05031,map05034 M00037,M00042 R00685,R00699,R00736,R02080,R02701,R04909 RC00299 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Pyridoxal_deC k59_1385471_1 319224.Sputcn32_2047 3.16e-99 322.0 COG3507@1|root,COG3507@2|Bacteria,1R4H2@1224|Proteobacteria,1RSCC@1236|Gammaproteobacteria,2QAFW@267890|Shewanellaceae 1236|Gammaproteobacteria G C-terminal of Glycosyl hydrolases family 43 - - 3.2.1.99 ko:K06113 - - - - ko00000,ko01000 - GH43 - GH43_C,Glyco_hydro_43,Laminin_G_3 k59_930191_1 1229909.NSED_09640 1.2e-92 281.0 COG1474@1|root,arCOG00467@2157|Archaea,41SED@651137|Thaumarchaeota 651137|Thaumarchaeota L Involved in regulation of DNA replication - - - ko:K10725 - - - - ko00000,ko03032 - - - AAA_22,Cdc6_C k59_1555595_2 745718.JADT01000023_gene1446 4.49e-62 196.0 COG0479@1|root,COG0479@2|Bacteria,4NFR3@976|Bacteroidetes,1HYVV@117743|Flavobacteriia 976|Bacteroidetes C Succinate dehydrogenase fumarate reductase Fe-S protein subunit frdB - 1.3.5.1,1.3.5.4 ko:K00240 ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00149,M00173,M00374,M00376 R02164 RC00045 ko00000,ko00001,ko00002,ko01000 - - - Fer2_3,Fer4_7,Fer4_8 k59_1611149_1 1051985.l11_19340 1.93e-17 81.3 COG1076@1|root,COG1076@2|Bacteria,1RHZX@1224|Proteobacteria,2VSD5@28216|Betaproteobacteria,2KR7U@206351|Neisseriales 206351|Neisseriales O Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA hscB - - ko:K04082 - - - - ko00000,ko03029,ko03110 - - - DnaJ,HSCB_C k59_1611149_2 1001585.MDS_3772 2.09e-22 96.3 COG0443@1|root,COG0443@2|Bacteria,1MVQI@1224|Proteobacteria,1RN74@1236|Gammaproteobacteria,1YCW7@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria O Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB hscA GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0009266,GO:0009409,GO:0009628,GO:0009987,GO:0010467,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033554,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043531,GO:0044238,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0050896,GO:0051604,GO:0051716,GO:0070417,GO:0071704,GO:0097159,GO:0097367,GO:0097428,GO:1901265,GO:1901363,GO:1901564,GO:1902494,GO:1990230,GO:1990234 - ko:K04044 - - - - ko00000,ko03110 1.A.33 - - HSP70 k59_647817_1 1123270.ATUR01000006_gene175 5.32e-83 259.0 COG0318@1|root,COG0318@2|Bacteria,1MXAV@1224|Proteobacteria,2U3TX@28211|Alphaproteobacteria,2K1RX@204457|Sphingomonadales 204457|Sphingomonadales IQ AMP-binding enzyme - - - - - - - - - - - - AMP-binding,AMP-binding_C k59_593722_1 1163409.UUA_15121 3.66e-37 137.0 COG1174@1|root,COG1732@1|root,COG1174@2|Bacteria,COG1732@2|Bacteria,1MXA1@1224|Proteobacteria,1RQ1F@1236|Gammaproteobacteria,1X3EX@135614|Xanthomonadales 135614|Xanthomonadales P COG1732 Periplasmic glycine betaine choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) yehZ - - ko:K05845,ko:K05846 ko02010,map02010 M00209 - - ko00000,ko00001,ko00002,ko02000 3.A.1.12 - - BPD_transp_1,OpuAC k59_312276_1 498211.CJA_2201 2.4e-78 244.0 COG1054@1|root,COG1054@2|Bacteria,1MUFV@1224|Proteobacteria,1RNNU@1236|Gammaproteobacteria,1FG8A@10|Cellvibrio 1236|Gammaproteobacteria S Rhodanese Homology Domain yceA - - ko:K07146 - - - - ko00000 - - - Rhodanese,Rhodanese_C k59_422594_1 1415778.JQMM01000001_gene352 3.63e-108 335.0 COG0495@1|root,COG0495@2|Bacteria,1MV47@1224|Proteobacteria,1RP14@1236|Gammaproteobacteria,1J4T4@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Belongs to the class-I aminoacyl-tRNA synthetase family leuS GO:0003674,GO:0003824,GO:0004812,GO:0004823,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006429,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.4 ko:K01869 ko00970,map00970 M00359,M00360 R03657 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - iECOK1_1307.ECOK1_0652,iECS88_1305.ECS88_0684,iNRG857_1313.NRG857_02925,iPC815.YPO2610 Anticodon_1,tRNA-synt_1,tRNA-synt_1_2 k59_86740_1 1123279.ATUS01000001_gene1088 1.3e-113 339.0 COG0004@1|root,COG0004@2|Bacteria,1NR9F@1224|Proteobacteria,1RNKF@1236|Gammaproteobacteria,1J860@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P Ammonium Transporter Family amt - - ko:K03320 - - - - ko00000,ko02000 1.A.11 - - Ammonium_transp k59_369133_1 1122197.ATWI01000013_gene2337 2.98e-29 113.0 COG0115@1|root,COG0115@2|Bacteria,1MVB0@1224|Proteobacteria,1RP6Z@1236|Gammaproteobacteria,465RB@72275|Alteromonadaceae 1236|Gammaproteobacteria E Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family ilvE GO:0003674,GO:0003824,GO:0004084,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006531,GO:0006532,GO:0006551,GO:0006573,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009081,GO:0009082,GO:0009098,GO:0009099,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0019752,GO:0042802,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.6.1.42 ko:K00826 ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00036,M00119,M00570 R01090,R01214,R02199,R10991 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 - - iB21_1397.B21_03597,iECBD_1354.ECBD_4269,iECB_1328.ECB_03648,iECD_1391.ECD_03648,iECO103_1326.ECO103_4394 Aminotran_4 k59_593743_1 697282.Mettu_1440 3.93e-53 177.0 COG0582@1|root,COG0582@2|Bacteria,1MWBN@1224|Proteobacteria,1RPD0@1236|Gammaproteobacteria,1XFIU@135618|Methylococcales 1236|Gammaproteobacteria L Belongs to the 'phage' integrase family - - - - - - - - - - - - Phage_integrase k59_1498922_1 1088868.CIN_17140 2.51e-79 251.0 COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,2TQPZ@28211|Alphaproteobacteria,2JQVG@204441|Rhodospirillales 204441|Rhodospirillales O Belongs to the peptidase S1C family - - 3.4.21.107 ko:K04771 ko01503,ko02020,map01503,map02020 M00728 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 - - - PDZ_2,Trypsin_2 k59_1498923_1 158500.BV97_03427 1.06e-92 281.0 COG0389@1|root,COG0389@2|Bacteria,1MUUH@1224|Proteobacteria,2TSJN@28211|Alphaproteobacteria,2K1Q4@204457|Sphingomonadales 204457|Sphingomonadales L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII dinB - 2.7.7.7 ko:K02346 - - - - ko00000,ko01000,ko03400 - - - IMS,IMS_C,IMS_HHH k59_1269174_1 1125779.HMPREF1219_02048 2.08e-25 115.0 COG0210@1|root,COG2887@1|root,COG0210@2|Bacteria,COG2887@2|Bacteria,2GM2E@201174|Actinobacteria,22KHN@1653|Corynebacteriaceae 201174|Actinobacteria L Belongs to the helicase family. UvrD subfamily uvrD2 - 3.6.4.12 ko:K03657 ko03420,ko03430,map03420,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - PDDEXK_1,UvrD-helicase,UvrD_C k59_1325991_1 666681.M301_2224 1.18e-73 229.0 COG0600@1|root,COG0600@2|Bacteria,1MWDJ@1224|Proteobacteria,2VMK8@28216|Betaproteobacteria,2KM22@206350|Nitrosomonadales 206350|Nitrosomonadales P Binding-protein-dependent transport system inner membrane component - - - ko:K02050 - M00188 - - ko00000,ko00002,ko02000 3.A.1.16,3.A.1.17 - - BPD_transp_1 k59_593752_1 292459.STH1427 4.83e-29 119.0 COG1132@1|root,COG1132@2|Bacteria,1UZA0@1239|Firmicutes,24DXZ@186801|Clostridia 186801|Clostridia V ABC transporter transmembrane region - - - ko:K06147 - - - - ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran k59_647842_1 448385.sce7166 3.57e-32 122.0 COG0420@1|root,COG0420@2|Bacteria,1MXMJ@1224|Proteobacteria,42Q5U@68525|delta/epsilon subdivisions,2WINF@28221|Deltaproteobacteria,2Z0R7@29|Myxococcales 28221|Deltaproteobacteria L Calcineurin-like phosphoesterase superfamily domain sbcD-1 - - ko:K03547 - - - - ko00000,ko03400 - - - Metallophos,Metallophos_2 k59_430464_1 237727.NAP1_10103 1.87e-30 118.0 COG2355@1|root,COG2355@2|Bacteria,1MWEW@1224|Proteobacteria,2TR5C@28211|Alphaproteobacteria,2K0GT@204457|Sphingomonadales 204457|Sphingomonadales E Zn-dependent dipeptidase, microsomal dipeptidase - - 3.4.13.19 ko:K01273 - - - - ko00000,ko00537,ko01000,ko01002,ko04147 - - - Peptidase_M19 k59_430464_2 1114964.L485_09185 5.48e-21 87.8 COG1226@1|root,32YV7@2|Bacteria,1N7MV@1224|Proteobacteria,2UMMN@28211|Alphaproteobacteria,2KDAI@204457|Sphingomonadales 204457|Sphingomonadales P Ion channel - - - - - - - - - - - - Ion_trans_2 k59_887720_1 1046627.BZARG_558 5.26e-86 258.0 COG0745@1|root,COG0745@2|Bacteria,4NG7D@976|Bacteroidetes,1HWZ6@117743|Flavobacteriia 976|Bacteroidetes T Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain phoP - - ko:K07658 ko02020,map02020 M00434 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Trans_reg_C k59_887720_2 504487.JCM19302_3227 1.79e-36 126.0 COG5002@1|root,COG5002@2|Bacteria,4P6AV@976|Bacteroidetes,1IAK6@117743|Flavobacteriia 976|Bacteroidetes T protein histidine kinase activity - - 2.7.13.3 ko:K07636 ko02020,map02020 M00434 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - - k59_264472_1 522373.Smlt3193 1.98e-73 234.0 COG0015@1|root,COG0015@2|Bacteria,1MV4B@1224|Proteobacteria,1RN93@1236|Gammaproteobacteria,1X3E0@135614|Xanthomonadales 135614|Xanthomonadales F Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily purB - 4.3.2.2 ko:K01756 ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130 M00048,M00049 R01083,R04559 RC00379,RC00444,RC00445 ko00000,ko00001,ko00002,ko01000 - - - ASL_C,Lyase_1 k59_1223816_1 1192759.AKIB01000104_gene3329 1.9e-91 286.0 COG2234@1|root,COG2234@2|Bacteria,1MV86@1224|Proteobacteria,2TVJ5@28211|Alphaproteobacteria,2K04D@204457|Sphingomonadales 204457|Sphingomonadales S Peptidase, M28 - - - - - - - - - - - - PA,Peptidase_M28 k59_1223820_1 326297.Sama_3575 1.41e-55 193.0 COG0596@1|root,COG0596@2|Bacteria,1R6KU@1224|Proteobacteria,1RNTQ@1236|Gammaproteobacteria,2QAGI@267890|Shewanellaceae 1236|Gammaproteobacteria S PFAM alpha beta hydrolase fold - - - - - - - - - - - - Abhydrolase_1,Abhydrolase_4 k59_1167766_1 316407.85675404 8.53e-107 307.0 2C10D@1|root,32RZ4@2|Bacteria,1RD7G@1224|Proteobacteria,1S4HS@1236|Gammaproteobacteria,3XPS1@561|Escherichia 1236|Gammaproteobacteria S Protein of unknown function (DUF2919) yfeZ GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - - - - - - - - - - DUF2919 k59_207232_1 383381.EH30_12160 5.52e-64 206.0 COG0124@1|root,COG0124@2|Bacteria,1MV2K@1224|Proteobacteria,2TSTH@28211|Alphaproteobacteria,2K101@204457|Sphingomonadales 204457|Sphingomonadales J histidyl-tRNA synthetase hisS - 6.1.1.21 ko:K01892 ko00970,map00970 M00359,M00360 R03655 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,tRNA-synt_His k59_1731847_1 247634.GPB2148_2481 8.67e-101 304.0 COG0438@1|root,COG0438@2|Bacteria,1N0DG@1224|Proteobacteria,1S0D6@1236|Gammaproteobacteria,1JAMS@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Glycosyl transferases group 1 - - - ko:K13004,ko:K21011 ko02025,map02025 - - - ko00000,ko00001,ko01000,ko01003,ko01005 - GT4 - Glyco_trans_1_4,Glyco_trans_4_2,Glycos_transf_1 k59_1447364_1 545264.KB898746_gene992 5.86e-51 170.0 COG0107@1|root,COG0107@2|Bacteria,1MUS0@1224|Proteobacteria,1RPJQ@1236|Gammaproteobacteria,1WY8J@135613|Chromatiales 135613|Chromatiales E IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit hisF - - ko:K02500 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R04558 RC00010,RC01190,RC01943 ko00000,ko00001,ko00002,ko01000 - - - His_biosynth k59_1333844_1 768671.ThimaDRAFT_0850 9.58e-94 289.0 COG3659@1|root,COG3659@2|Bacteria,1R8TI@1224|Proteobacteria,1S21B@1236|Gammaproteobacteria 1236|Gammaproteobacteria M Carbohydrate-selective porin OprB - - - ko:K07267 - - - - ko00000,ko02000 1.B.19.1 - - OprB k59_827426_1 1088721.NSU_3430 1.57e-59 192.0 COG1355@1|root,COG1355@2|Bacteria,1R369@1224|Proteobacteria,2TZYM@28211|Alphaproteobacteria,2KEW6@204457|Sphingomonadales 28211|Alphaproteobacteria S Catalytic LigB subunit of aromatic ring-opening dioxygenase - - 1.13.11.16,1.13.11.8 ko:K04101,ko:K05713 ko00360,ko00362,ko00624,ko00627,ko01120,ko01220,map00360,map00362,map00624,map00627,map01120,map01220 M00545 R01632,R03550,R04280,R04376,R06788,R09565 RC00233,RC00387,RC00535,RC01140,RC01364,RC02567,RC02694 br01602,ko00000,ko00001,ko00002,ko01000 - - - LigB k59_322967_1 1348583.ATLH01000013_gene3028 2.44e-64 211.0 COG2801@1|root,COG2801@2|Bacteria,4NM64@976|Bacteroidetes,1HZ28@117743|Flavobacteriia,1FADJ@104264|Cellulophaga 976|Bacteroidetes L COGs COG2801 Transposase and inactivated derivatives - - - - - - - - - - - - rve k59_1333849_1 436308.Nmar_1753 4.59e-90 278.0 arCOG08764@1|root,arCOG08764@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_149742_1 688270.Celal_3758 6.05e-31 132.0 COG0075@1|root,COG0726@1|root,COG5492@1|root,COG0075@2|Bacteria,COG0726@2|Bacteria,COG5492@2|Bacteria,4PNT2@976|Bacteroidetes,1IKBJ@117743|Flavobacteriia,1F9TB@104264|Cellulophaga 976|Bacteroidetes E Leucine-rich repeat (LRR) protein - - - - - - - - - - - - - k59_938821_1 426114.THI_2628 1.76e-124 375.0 COG1009@1|root,COG1009@2|Bacteria,1MW2M@1224|Proteobacteria,2VJ2J@28216|Betaproteobacteria,1KIU8@119065|unclassified Burkholderiales 28216|Betaproteobacteria CP TIGRFAM proton-translocating NADH-quinone oxidoreductase, chain L nuoL - 1.6.5.3 ko:K00341 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Proton_antipo_C,Proton_antipo_M,Proton_antipo_N k59_1447376_1 543913.D521_0168 7.69e-24 104.0 COG0771@1|root,COG0771@2|Bacteria,1MVYD@1224|Proteobacteria,2VHJ1@28216|Betaproteobacteria,1KPNA@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria D Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) murD - 6.3.2.9 ko:K01925 ko00471,ko00550,ko01100,map00471,map00550,map01100 - R02783 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase_C,Mur_ligase_M k59_1566378_1 1123279.ATUS01000001_gene2671 7.25e-159 452.0 COG1062@1|root,COG1062@2|Bacteria,1MUK4@1224|Proteobacteria,1RNQ4@1236|Gammaproteobacteria,1J4MG@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily adhC GO:0003674,GO:0003824,GO:0004022,GO:0004024,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0008150,GO:0008152,GO:0008270,GO:0009056,GO:0009636,GO:0009987,GO:0010033,GO:0016491,GO:0016614,GO:0016616,GO:0016999,GO:0017001,GO:0017144,GO:0042221,GO:0042802,GO:0043167,GO:0043169,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046185,GO:0046292,GO:0046294,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0051903,GO:0055114,GO:0070887,GO:0071704,GO:0097237,GO:0098754,GO:0110095,GO:0110096,GO:1901575,GO:1901700,GO:1901701,GO:1990748 1.1.1.1,1.1.1.284 ko:K00121 ko00010,ko00071,ko00350,ko00625,ko00626,ko00680,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,ko05204,map00010,map00071,map00350,map00625,map00626,map00680,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01200,map01220,map05204 - R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R06983,R07105,R08281,R08306,R08310 RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01715,RC01734,RC02273 ko00000,ko00001,ko01000 - - iEC042_1314.EC042_0393,iEC55989_1330.EC55989_0365,iECH74115_1262.ECH74115_0431,iECIAI1_1343.ECIAI1_0357,iECIAI39_1322.ECIAI39_0322,iECO103_1326.ECO103_0338,iECO111_1330.ECO111_0392,iECO26_1355.ECO26_0392,iECSE_1348.ECSE_0381,iECSP_1301.ECSP_0420,iECUMN_1333.ECUMN_0399,iECW_1372.ECW_m0434,iECs_1301.ECs0411,iEKO11_1354.EKO11_3486,iETEC_1333.ETEC_0412,iEcE24377_1341.EcE24377A_0381,iEcHS_1320.EcHS_A0421,iEcolC_1368.EcolC_3269,iG2583_1286.G2583_0469,iSSON_1240.SSON_0335,iSbBS512_1146.SbBS512_E0271,iUMNK88_1353.UMNK88_407,iWFL_1372.ECW_m0434,iZ_1308.Z0456 ADH_N,ADH_zinc_N k59_1566378_2 1122137.AQXF01000006_gene887 2.49e-120 349.0 COG0627@1|root,COG0627@2|Bacteria,1MUID@1224|Proteobacteria,2TQSM@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Serine hydrolase involved in the detoxification of formaldehyde fghA - 3.1.2.12 ko:K01070 ko00680,ko01120,ko01200,map00680,map01120,map01200 - R00527 RC00167,RC00320 ko00000,ko00001,ko01000 - CE1 - Esterase k59_149754_1 266264.Rmet_5309 2.48e-24 112.0 COG2203@1|root,COG3899@1|root,COG4191@1|root,COG2203@2|Bacteria,COG3899@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2VJXQ@28216|Betaproteobacteria,1KGF6@119060|Burkholderiaceae 28216|Betaproteobacteria T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - GAF_2,HATPase_c,HisKA,PAS_3 k59_541262_1 1122603.ATVI01000006_gene503 1.77e-109 330.0 COG4972@1|root,COG4972@2|Bacteria,1MX8P@1224|Proteobacteria,1RN8S@1236|Gammaproteobacteria,1X3US@135614|Xanthomonadales 135614|Xanthomonadales NU Pilus assembly protein pilM - - ko:K02662 - - - - ko00000,ko02035,ko02044 - - - PilM_2 k59_541263_1 1121033.AUCF01000001_gene2509 1.05e-24 97.8 COG0599@1|root,COG0599@2|Bacteria,1MZ80@1224|Proteobacteria,2UDE8@28211|Alphaproteobacteria,2JTBN@204441|Rhodospirillales 204441|Rhodospirillales S Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity - - - - - - - - - - - - CMD k59_541263_2 316055.RPE_2034 6.18e-10 57.4 COG0607@1|root,COG0607@2|Bacteria,1RHQZ@1224|Proteobacteria,2U9DZ@28211|Alphaproteobacteria,3JY2J@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria P Rhodanese Homology Domain MA20_01310 - - - - - - - - - - - Rhodanese k59_1447395_1 243233.MCA2493 8.64e-69 218.0 COG0777@1|root,COG0777@2|Bacteria,1MW8G@1224|Proteobacteria,1RNDS@1236|Gammaproteobacteria,1XDUU@135618|Methylococcales 135618|Methylococcales I Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA accD - 2.1.3.15,6.4.1.2 ko:K01963 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742,R04386 RC00040,RC00253,RC00367 ko00000,ko00001,ko00002,ko01000 - - - Carboxyl_trans k59_1731875_2 1380394.JADL01000002_gene1649 1.5e-81 257.0 COG1660@1|root,COG1660@2|Bacteria,1MVX6@1224|Proteobacteria,2TTI4@28211|Alphaproteobacteria,2JPS2@204441|Rhodospirillales 204441|Rhodospirillales T Displays ATPase and GTPase activities - - - ko:K06958 - - - - ko00000,ko03019 - - - ATP_bind_2,Hpr_kinase_C k59_1731875_3 1122137.AQXF01000001_gene2968 1.82e-72 219.0 COG2893@1|root,COG2893@2|Bacteria,1RHH7@1224|Proteobacteria,2U9E5@28211|Alphaproteobacteria 28211|Alphaproteobacteria G Phosphotransferase system mannose fructose-specific component IIA manX - 2.7.1.191 ko:K02793 ko00051,ko00520,ko01100,ko02060,map00051,map00520,map01100,map02060 M00276 R02630 RC00017,RC03206 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.6.1 - - EIIA-man k59_1731875_4 314266.SKA58_05840 1.17e-24 95.5 COG1925@1|root,COG1925@2|Bacteria,1N6RM@1224|Proteobacteria,2UC0H@28211|Alphaproteobacteria,2K638@204457|Sphingomonadales 204457|Sphingomonadales G COG1925 Phosphotransferase system, HPr-related proteins ptsH - - ko:K11189 - - - - ko00000,ko02000 4.A.2.1 - - PTS-HPr k59_1276960_1 404589.Anae109_4362 4.16e-41 154.0 COG0046@1|root,COG0046@2|Bacteria,1MYN4@1224|Proteobacteria,42M08@68525|delta/epsilon subdivisions,2WITS@28221|Deltaproteobacteria,2YUCV@29|Myxococcales 28221|Deltaproteobacteria F Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL purL - 6.3.5.3 ko:K01952 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04463 RC00010,RC01160 ko00000,ko00001,ko00002,ko01000 - - - AIRS,AIRS_C,PurS k59_1673662_1 983917.RGE_29690 6.46e-33 129.0 COG4941@1|root,COG4941@2|Bacteria,1MU3D@1224|Proteobacteria,2VKYD@28216|Betaproteobacteria,1KJSG@119065|unclassified Burkholderiales 28216|Betaproteobacteria K Sigma-70 region 2 - - - - - - - - - - - - Sigma70_r2,Sigma70_r4_2 k59_207281_1 1163409.UUA_17450 1.08e-21 96.3 COG3358@1|root,COG3358@2|Bacteria,1R9CT@1224|Proteobacteria,1SP2S@1236|Gammaproteobacteria,1X42J@135614|Xanthomonadales 135614|Xanthomonadales S Protein of unknown function (DUF1684) - - - ko:K09164 - - - - ko00000 - - - DUF1684 k59_1783830_1 397945.Aave_3567 1.67e-19 89.4 COG4338@1|root,COG4338@2|Bacteria,1N3G5@1224|Proteobacteria,2VUMZ@28216|Betaproteobacteria,4AF09@80864|Comamonadaceae 28216|Betaproteobacteria S Protein conserved in bacteria - - - - - - - - - - - - - k59_994144_1 396588.Tgr7_2285 1.11e-56 188.0 COG3864@1|root,COG3864@2|Bacteria,1MY13@1224|Proteobacteria,1RXX2@1236|Gammaproteobacteria,1WX24@135613|Chromatiales 135613|Chromatiales S VWA-like domain (DUF2201) - - - - - - - - - - - - DUF2201,DUF2201_N k59_379385_1 1500301.JQMF01000034_gene4401 2.22e-58 198.0 COG1116@1|root,COG1116@2|Bacteria,1MUDV@1224|Proteobacteria,2TSH9@28211|Alphaproteobacteria,4BAAI@82115|Rhizobiaceae 28211|Alphaproteobacteria P ABC transporter - - - ko:K02049,ko:K15555,ko:K15578 ko00910,ko00920,ko02010,map00910,map00920,map02010 M00188,M00436,M00438 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.16,3.A.1.16.1,3.A.1.17,3.A.1.17.2 - - ABC_tran k59_887775_2 1449068.JMLQ01000001_gene251 7.1e-62 208.0 COG1028@1|root,COG1028@2|Bacteria,2GIYQ@201174|Actinobacteria,4FZCN@85025|Nocardiaceae 201174|Actinobacteria IQ NAD dependent epimerase/dehydratase family - - - - - - - - - - - - adh_short k59_1447415_1 204669.Acid345_2175 1.23e-07 60.5 COG4235@1|root,COG4235@2|Bacteria 2|Bacteria O cytochrome complex assembly - - - ko:K02200,ko:K04018 - - - - ko00000 - - - TPR_16,TPR_19 k59_95386_1 1122137.AQXF01000006_gene813 4.8e-30 117.0 2C8CD@1|root,2Z9AD@2|Bacteria,1N17D@1224|Proteobacteria,2U86Q@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_95386_2 1122137.AQXF01000006_gene810 1.76e-87 269.0 COG0626@1|root,COG0626@2|Bacteria,1MU9E@1224|Proteobacteria,2TS8Z@28211|Alphaproteobacteria 28211|Alphaproteobacteria E cystathionine metC - 4.4.1.8 ko:K01760 ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230 M00017 R00782,R01286,R02408,R04941 RC00056,RC00069,RC00382,RC00488,RC00710,RC01245,RC02303 ko00000,ko00001,ko00002,ko01000 - - - Cys_Met_Meta_PP k59_768678_1 1121396.KB893065_gene1609 1.03e-123 386.0 COG4249@1|root,COG4249@2|Bacteria,1MXS7@1224|Proteobacteria,43AXK@68525|delta/epsilon subdivisions,2X6BU@28221|Deltaproteobacteria,2MN2G@213118|Desulfobacterales 28221|Deltaproteobacteria S Caspase domain - - - - - - - - - - - - Peptidase_C14 k59_994153_1 1122137.AQXF01000002_gene480 7e-48 167.0 COG0534@1|root,COG0534@2|Bacteria,1MVRV@1224|Proteobacteria,2U34G@28211|Alphaproteobacteria 28211|Alphaproteobacteria V Mate efflux family protein - - - - - - - - - - - - MatE k59_1566413_1 435908.IDSA_04455 1.78e-83 267.0 COG0073@1|root,COG0143@1|root,COG0073@2|Bacteria,COG0143@2|Bacteria,1MUBY@1224|Proteobacteria,1RMYM@1236|Gammaproteobacteria,2QEYD@267893|Idiomarinaceae 1236|Gammaproteobacteria J Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation metG GO:0003674,GO:0003824,GO:0004812,GO:0004825,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006431,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.10 ko:K01874 ko00450,ko00970,map00450,map00970 M00359,M00360 R03659,R04773 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iEC042_1314.EC042_2346,iECUMN_1333.ECUMN_2446 Anticodon_1,tRNA-synt_1g,tRNA_bind k59_323008_2 1034769.KB910518_gene806 6.19e-10 60.5 COG1092@1|root,COG1092@2|Bacteria,1TRAJ@1239|Firmicutes,4HAA1@91061|Bacilli,26S9E@186822|Paenibacillaceae 91061|Bacilli J SAM-dependent methyltransferase rlmI - 2.1.1.191 ko:K06969 - - - - ko00000,ko01000,ko03009 - - - Cons_hypoth95,Met_10,Methyltrans_SAM,Methyltransf_31 k59_264552_2 1206739.BAGJ01000170_gene2407 3.53e-15 78.6 COG1020@1|root,COG1020@2|Bacteria,2H1RQ@201174|Actinobacteria,4G900@85025|Nocardiaceae 201174|Actinobacteria Q Protein of unknown function (DUF1298) - - - - - - - - - - - - DUF1298,WES_acyltransf k59_486213_1 930169.B5T_00466 3.61e-48 164.0 COG0730@1|root,COG0730@2|Bacteria,1R3V4@1224|Proteobacteria,1RVNC@1236|Gammaproteobacteria,1XIIG@135619|Oceanospirillales 135619|Oceanospirillales S membrane transporter protein - - - ko:K07090 - - - - ko00000 - - - TauE k59_717644_1 1279017.AQYJ01000029_gene3464 4.79e-18 88.6 COG3209@1|root,COG3209@2|Bacteria,1MVV1@1224|Proteobacteria,1RMPT@1236|Gammaproteobacteria,464DD@72275|Alteromonadaceae 1236|Gammaproteobacteria M COG3209 Rhs family protein - - - - - - - - - - - - RHS_repeat,SpvB,TcdB_toxin_midN,VCBS k59_887805_1 585531.HMPREF0063_10756 1.01e-11 68.9 COG1994@1|root,COG1994@2|Bacteria,2GJBZ@201174|Actinobacteria,4DNGY@85009|Propionibacteriales 201174|Actinobacteria S Belongs to the peptidase M50B family - - - - - - - - - - - - CBS,Peptidase_M50,Peptidase_M50B k59_1223920_1 1280949.HAD_05125 2.04e-09 59.3 COG0405@1|root,COG0405@2|Bacteria,1Q089@1224|Proteobacteria,2U8PM@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Gamma-glutamyltranspeptidase - - 2.3.2.2,3.4.19.13 ko:K00681 ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100 - R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935 RC00064,RC00090,RC00096 ko00000,ko00001,ko01000,ko01002 - - - G_glu_transpept k59_1223920_2 384765.SIAM614_17444 1.43e-25 106.0 COG0642@1|root,COG2205@2|Bacteria,1MUAK@1224|Proteobacteria,2TSUC@28211|Alphaproteobacteria 28211|Alphaproteobacteria T Histidine kinase - - - - - - - - - - - - HAMP,HATPase_c,HisKA k59_1619432_2 1203554.HMPREF1476_00607 8.95e-29 113.0 COG0164@1|root,COG0164@2|Bacteria,1RA65@1224|Proteobacteria,2VQ06@28216|Betaproteobacteria,4PQY1@995019|Sutterellaceae 28216|Betaproteobacteria L Endonuclease that specifically degrades the RNA of RNA- DNA hybrids rnhB - 3.1.26.4 ko:K03470 ko03030,map03030 - - - ko00000,ko00001,ko01000,ko03032 - - - RNase_HII k59_1333931_2 983920.Y88_2667 1.95e-59 196.0 COG0389@1|root,COG0389@2|Bacteria,1MUUH@1224|Proteobacteria,2TSJN@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII dinB - 2.7.7.7 ko:K02346 - - - - ko00000,ko01000,ko03400 - - - IMS,IMS_C,IMS_HHH k59_604544_1 330214.NIDE0233 3.56e-115 340.0 COG0649@1|root,COG0649@2|Bacteria,3J0FM@40117|Nitrospirae 40117|Nitrospirae C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoD - 1.6.5.3 ko:K00333,ko:K13378 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_49kDa,NiFeSe_Hases k59_1447450_1 504832.OCAR_7097 5.47e-100 296.0 COG1028@1|root,COG1028@2|Bacteria,1NBB6@1224|Proteobacteria,2TVF5@28211|Alphaproteobacteria,3JXK5@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria IQ Enoyl-(Acyl carrier protein) reductase - - 1.1.1.100 ko:K00059 ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212 M00083,M00572 R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671 RC00029,RC00117 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short,adh_short_C2 k59_323032_1 1144305.PMI02_04051 5.85e-94 293.0 COG4770@1|root,COG4770@2|Bacteria,1P6RE@1224|Proteobacteria,2TRC2@28211|Alphaproteobacteria,2K27B@204457|Sphingomonadales 204457|Sphingomonadales I acetyl propionyl-CoA carboxylase, alpha subunit - - 6.4.1.4 ko:K01968 ko00280,ko01100,map00280,map01100 M00036 R04138 RC00367,RC00942 ko00000,ko00001,ko00002,ko01000 - - - Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2 k59_95425_1 1123269.NX02_02715 6.28e-104 306.0 COG0623@1|root,COG0623@2|Bacteria,1MV05@1224|Proteobacteria,2TSU4@28211|Alphaproteobacteria,2K266@204457|Sphingomonadales 204457|Sphingomonadales I Catalyzes a key regulatory step in fatty acid biosynthesis - - 1.3.1.10,1.3.1.9 ko:K00208 ko00061,ko00333,ko00780,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01100,map01130,map01212 M00083,M00572 R01404,R04429,R04430,R04724,R04725,R04955,R04956,R04958,R04959,R04961,R04962,R04966,R04967,R04969,R04970,R07765,R10118,R10122,R11671 RC00052,RC00076,RC00120 ko00000,ko00001,ko00002,ko01000,ko01004 - - - adh_short_C2 k59_95425_2 685035.ADAE01000013_gene48 1.1e-06 48.9 COG0282@1|root,COG0282@2|Bacteria,1MW61@1224|Proteobacteria,2TQQQ@28211|Alphaproteobacteria,2K34Z@204457|Sphingomonadales 204457|Sphingomonadales H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction ackA - 2.7.2.1 ko:K00925 ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200 M00357,M00579 R00315,R01353 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - Acetate_kinase k59_1396022_1 204536.SULAZ_0555 1.88e-106 315.0 COG0426@1|root,COG0426@2|Bacteria,2G4SU@200783|Aquificae 200783|Aquificae C Metallo-beta-lactamase superfamily - - - - - - - - - - - - Lactamase_B k59_768727_1 1268239.PALB_3560 2.67e-52 166.0 COG0261@1|root,COG0261@2|Bacteria,1MZEW@1224|Proteobacteria,1S5VB@1236|Gammaproteobacteria,2Q2C0@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria J This protein binds to 23S rRNA in the presence of protein L20 rplU GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02888 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L21p k59_1447459_1 1411123.JQNH01000001_gene1371 1.41e-44 167.0 COG0188@1|root,COG0188@2|Bacteria,1MUGG@1224|Proteobacteria,2TSPQ@28211|Alphaproteobacteria 28211|Alphaproteobacteria L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrA - 5.99.1.3 ko:K02469 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseA_C,DNA_topoisoIV k59_938887_1 157072.XP_008861628.1 2.15e-40 155.0 COG0265@1|root,KOG1421@2759|Eukaryota 2759|Eukaryota O serine-type endopeptidase activity DEG7 GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009314,GO:0009416,GO:0009507,GO:0009536,GO:0009628,GO:0009642,GO:0009644,GO:0009892,GO:0010109,GO:0010205,GO:0016787,GO:0019222,GO:0019538,GO:0031323,GO:0031324,GO:0042548,GO:0043155,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043467,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0065007,GO:0071704,GO:0140096,GO:1901564,GO:1905156 - - - - - - - - - - PDZ_1,PDZ_2,Trypsin_2 k59_1509012_1 1283283.ATXA01000001_gene794 4.97e-19 91.3 COG1132@1|root,COG1132@2|Bacteria,2GITR@201174|Actinobacteria,4ES40@85013|Frankiales 201174|Actinobacteria V ABC transporter - - - ko:K06147 - - - - ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran k59_207335_1 396588.Tgr7_2986 1.84e-52 180.0 COG0612@1|root,COG0612@2|Bacteria,1MU6R@1224|Proteobacteria,1RN3E@1236|Gammaproteobacteria,1WXE8@135613|Chromatiales 135613|Chromatiales S PFAM Peptidase M16 - - - ko:K07263 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M16,Peptidase_M16_C k59_827543_1 1125863.JAFN01000001_gene1973 4.13e-110 331.0 COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,42MGZ@68525|delta/epsilon subdivisions,2WIY6@28221|Deltaproteobacteria 28221|Deltaproteobacteria L Belongs to the DEAD box helicase family rhlE-2 - 3.6.4.13 ko:K11927 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - DEAD,Helicase_C k59_938899_1 1120958.AULD01000006_gene573 2.18e-23 108.0 COG1316@1|root,COG1316@2|Bacteria,2GM55@201174|Actinobacteria,4FKR4@85023|Microbacteriaceae 201174|Actinobacteria K Cell envelope-related transcriptional attenuator domain - - - - - - - - - - - - LytR_cpsA_psr k59_541379_1 1453501.JELR01000001_gene2395 8.3e-17 81.3 COG1946@1|root,COG1946@2|Bacteria,1MV9R@1224|Proteobacteria,1RPFI@1236|Gammaproteobacteria,464I0@72275|Alteromonadaceae 1236|Gammaproteobacteria I Acyl-CoA thioesterase tesB GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006163,GO:0006629,GO:0006631,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009117,GO:0009150,GO:0009259,GO:0009987,GO:0016042,GO:0016054,GO:0016289,GO:0016787,GO:0016788,GO:0016790,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0033865,GO:0033875,GO:0034032,GO:0034641,GO:0035383,GO:0042802,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0046483,GO:0047617,GO:0051186,GO:0055086,GO:0071704,GO:0072329,GO:0072521,GO:1901135,GO:1901360,GO:1901564,GO:1901575 - ko:K10805 ko01040,map01040 - - - ko00000,ko00001,ko01000,ko01004 - - iAF1260.b0452,iB21_1397.B21_00408,iBWG_1329.BWG_0334,iEC55989_1330.EC55989_0466,iECBD_1354.ECBD_3203,iECB_1328.ECB_00404,iECDH10B_1368.ECDH10B_0408,iECDH1ME8569_1439.ECDH1ME8569_0437,iECD_1391.ECD_00404,iECH74115_1262.ECH74115_0541,iECIAI1_1343.ECIAI1_0456,iECIAI39_1322.ECIAI39_0221,iECO103_1326.ECO103_0429,iECO111_1330.ECO111_0485,iECO26_1355.ECO26_0487,iECSE_1348.ECSE_0478,iECSP_1301.ECSP_0520,iECUMN_1333.ECUMN_0492,iECW_1372.ECW_m0524,iECs_1301.ECs0506,iEKO11_1354.EKO11_3394,iETEC_1333.ETEC_0505,iEcDH1_1363.EcDH1_3157,iEcE24377_1341.EcE24377A_0488,iEcHS_1320.EcHS_A0529,iEcSMS35_1347.EcSMS35_0496,iEcolC_1368.EcolC_3163,iG2583_1286.G2583_0564,iJO1366.b0452,iSSON_1240.SSON_0440,iUMNK88_1353.UMNK88_505,iWFL_1372.ECW_m0524,iY75_1357.Y75_RS02335,iZ_1308.Z0564,ic_1306.c0571 4HBT_3,Acyl_CoA_thio k59_1566471_1 1128421.JAGA01000002_gene1080 9.6e-26 108.0 COG2133@1|root,COG2133@2|Bacteria,2NNSP@2323|unclassified Bacteria 2|Bacteria G Glucose / Sorbosone dehydrogenase - - - - - - - - - - - - CBM_2,GSDH k59_1731946_1 322710.Avin_09260 2.14e-102 309.0 COG0001@1|root,COG0001@2|Bacteria,1MUY5@1224|Proteobacteria,1RM7N@1236|Gammaproteobacteria 1236|Gammaproteobacteria H Glutamate-1-semialdehyde aminotransferase hemL GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006725,GO:0006778,GO:0006779,GO:0006782,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016853,GO:0016866,GO:0016869,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042286,GO:0042440,GO:0042802,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046483,GO:0046501,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 5.4.3.8 ko:K01845 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R02272 RC00677 ko00000,ko00001,ko00002,ko01000,ko01007 - - iUMNK88_1353.UMNK88_158 Aminotran_3 k59_656368_1 1172186.KB911467_gene1991 2.59e-40 152.0 COG1075@1|root,COG1075@2|Bacteria,2IBAW@201174|Actinobacteria,238FC@1762|Mycobacteriaceae 201174|Actinobacteria S Putative serine esterase (DUF676) - - - - - - - - - - - - Abhydrolase_6,DUF676,PGAP1 k59_1224854_1 375286.mma_1705 9.54e-52 181.0 COG2831@1|root,COG2831@2|Bacteria,1PRBP@1224|Proteobacteria,2VHDS@28216|Betaproteobacteria,475Q6@75682|Oxalobacteraceae 28216|Betaproteobacteria U Hemolysin activation secretion protein - - - - - - - - - - - - POTRA,POTRA_2,ShlB k59_96396_1 765910.MARPU_10590 3.39e-10 66.2 COG0657@1|root,COG0657@2|Bacteria,1MVRE@1224|Proteobacteria,1S0ZD@1236|Gammaproteobacteria,1WYKB@135613|Chromatiales 135613|Chromatiales I Pectinacetylesterase - - - - - - - - - - - - PAE k59_1056925_2 1109445.AGSX01000187_gene2374 2.76e-42 152.0 COG0442@1|root,COG0442@2|Bacteria,1MU7E@1224|Proteobacteria,1RN5R@1236|Gammaproteobacteria,1Z0T5@136846|Pseudomonas stutzeri group 1236|Gammaproteobacteria J Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS proS GO:0002161,GO:0003674,GO:0003824,GO:0004812,GO:0004827,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006433,GO:0006450,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0043906,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.15 ko:K01881 ko00970,map00970 M00359,M00360 R03661 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iUTI89_1310.UTI89_C0210 HGTP_anticodon,tRNA-synt_2b,tRNA_edit k59_769607_1 179408.Osc7112_1971 3.34e-05 55.5 COG2931@1|root,COG2931@2|Bacteria,1G1I0@1117|Cyanobacteria,1H84J@1150|Oscillatoriales 1117|Cyanobacteria Q RTX toxins and related Ca2 binding proteins - - - - - - - - - - - - Cadherin_3,FG-GAP,HemolysinCabind,SdrD_B k59_1448300_1 948106.AWZT01000001_gene5021 2.99e-13 67.8 COG0036@1|root,COG0036@2|Bacteria,1MUZM@1224|Proteobacteria,2VIGU@28216|Betaproteobacteria,1K5C5@119060|Burkholderiaceae 28216|Betaproteobacteria G Ribulose-phosphate 3 epimerase family rpe - 5.1.3.1 ko:K01783 ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007 R01529 RC00540 ko00000,ko00001,ko00002,ko01000 - - - Ribul_P_3_epim k59_1448300_2 991905.SL003B_2433 8.59e-36 140.0 COG0144@1|root,COG0144@2|Bacteria,1MV2Q@1224|Proteobacteria,2TS6U@28211|Alphaproteobacteria,4BQ05@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria J 16S rRNA methyltransferase RsmB/F sun1 - 2.1.1.176 ko:K03500 - - - - ko00000,ko01000,ko03009 - - - Methyltr_RsmB-F k59_1278218_1 158500.BV97_02747 1.84e-100 301.0 COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,2TS06@28211|Alphaproteobacteria,2K18C@204457|Sphingomonadales 204457|Sphingomonadales E aminotransferase - - - - - - - - - - - - Aminotran_1_2 k59_208319_1 82654.Pse7367_3268 3.18e-52 179.0 COG3552@1|root,COG3552@2|Bacteria 2|Bacteria S VWA domain containing CoxE-like protein yehP - - - - - - - - - - - VWA_CoxE k59_1683655_2 190650.CC_2035 7.76e-21 92.0 COG1331@1|root,COG1331@2|Bacteria,1R570@1224|Proteobacteria,2TUBQ@28211|Alphaproteobacteria,2KFKA@204458|Caulobacterales 204458|Caulobacterales O Pectic acid lyase - - - - - - - - - - - - Pec_lyase k59_1628399_1 436308.Nmar_0231 3.41e-42 154.0 arCOG06534@1|root,arCOG06534@2157|Archaea 2157|Archaea S acid phosphatase activity - - - - - - - - - - - - He_PIG k59_897282_1 644282.Deba_1934 5.42e-07 56.2 COG1639@1|root,COG1639@2|Bacteria,1RAH3@1224|Proteobacteria,42PRF@68525|delta/epsilon subdivisions,2WQQK@28221|Deltaproteobacteria 28221|Deltaproteobacteria T PFAM Metal-dependent hydrolase HDOD - - - - - - - - - - - - HDOD k59_495284_1 1384056.N787_06780 5.54e-58 202.0 COG2352@1|root,COG2352@2|Bacteria,1MUD5@1224|Proteobacteria,1RPTP@1236|Gammaproteobacteria,1X4MI@135614|Xanthomonadales 135614|Xanthomonadales C Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle ppc GO:0003674,GO:0003824,GO:0004611,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008964,GO:0016829,GO:0016830,GO:0016831,GO:0044424,GO:0044444,GO:0044464 4.1.1.31 ko:K01595 ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200 M00168,M00170,M00171,M00172,M00173,M00346,M00374 R00345 RC02741 ko00000,ko00001,ko00002,ko01000 - - - PEPcase k59_777443_1 483219.LILAB_34555 1.63e-140 426.0 COG0653@1|root,COG0653@2|Bacteria,1MUJZ@1224|Proteobacteria,42MMV@68525|delta/epsilon subdivisions,2WIZ4@28221|Deltaproteobacteria,2YU97@29|Myxococcales 28221|Deltaproteobacteria U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane secA GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680 - ko:K03070 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4 - - Helicase_C,SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW k59_1176510_1 243233.MCA1959 2.36e-32 119.0 COG0625@1|root,COG0625@2|Bacteria,1MXJD@1224|Proteobacteria,1RP12@1236|Gammaproteobacteria,1XDPJ@135618|Methylococcales 135618|Methylococcales O PFAM Glutathione S-transferase, N-terminal sspA - - ko:K03599 - - - - ko00000,ko02000,ko03021 1.A.12.3.1 - - GST_C,GST_N_3 k59_1176510_2 686340.Metal_0305 3.62e-40 137.0 COG2969@1|root,COG2969@2|Bacteria,1MZ2Q@1224|Proteobacteria,1S8WT@1236|Gammaproteobacteria,1XFC6@135618|Methylococcales 135618|Methylococcales S PFAM Stringent starvation protein B sspB - - ko:K03600 - - - - ko00000,ko03021 - - - SspB k59_388912_1 228405.HNE_2503 2.46e-08 54.3 COG0145@1|root,COG0145@2|Bacteria,1MU2Y@1224|Proteobacteria,2TRBN@28211|Alphaproteobacteria,43W66@69657|Hyphomonadaceae 28211|Alphaproteobacteria EQ Hydantoinase/oxoprolinase N-terminal region - - - - - - - - - - - - Hydant_A_N,Hydantoinase_A k59_388912_2 983920.Y88_0045 1.97e-05 52.0 COG2909@1|root,COG2909@2|Bacteria,1MVZZ@1224|Proteobacteria,2U296@28211|Alphaproteobacteria,2K9GY@204457|Sphingomonadales 204457|Sphingomonadales K helix_turn_helix, Lux Regulon - - - ko:K03556 - - - - ko00000,ko03000 - - - GerE k59_158955_2 428125.CLOLEP_00448 9.84e-13 65.5 COG0227@1|root,COG0227@2|Bacteria,1VEI2@1239|Firmicutes,24QNA@186801|Clostridia,3WKM9@541000|Ruminococcaceae 186801|Clostridia J Belongs to the bacterial ribosomal protein bL28 family rpmB - - ko:K02902 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L28 k59_1176520_1 935567.JAES01000004_gene110 8.3e-52 176.0 COG2021@1|root,COG2021@2|Bacteria,1MVJV@1224|Proteobacteria,1RQ2N@1236|Gammaproteobacteria,1X47D@135614|Xanthomonadales 135614|Xanthomonadales E Transfers a succinyl group from succinyl-CoA to L- serine, forming succinyl-L-serine metX GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004414,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008374,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009086,GO:0009092,GO:0009987,GO:0016053,GO:0016407,GO:0016413,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.3.1.31 ko:K00641 ko00270,ko01100,ko01130,map00270,map01100,map01130 - R01776 RC00004,RC00041 ko00000,ko00001,ko01000 - - - Abhydrolase_1 k59_1343267_1 34506.g2227 1.76e-95 323.0 COG0524@1|root,COG0642@1|root,KOG0519@2759|Eukaryota,KOG2855@2759|Eukaryota 2759|Eukaryota G carbohydrate kinase activity - - - - - - - - - - - - HATPase_c,HisKA,PAS,PfkB,Response_reg k59_1343267_2 243231.GSU0890 8.5e-76 249.0 COG0272@1|root,COG0272@2|Bacteria,1MV3R@1224|Proteobacteria,42MC5@68525|delta/epsilon subdivisions,2WIT5@28221|Deltaproteobacteria,43TM8@69541|Desulfuromonadales 28221|Deltaproteobacteria L DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA ligA GO:0003674,GO:0003824,GO:0003909,GO:0003911,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016874,GO:0016886,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360 6.5.1.2 ko:K01972 ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430 - R00382 RC00005 ko00000,ko00001,ko01000,ko03032,ko03400 - - - BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5 k59_1117882_1 395493.BegalDRAFT_0276 1.29e-49 176.0 COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,1RME8@1236|Gammaproteobacteria,45ZVM@72273|Thiotrichales 72273|Thiotrichales O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins ftsH - - ko:K03798 - M00742 - - ko00000,ko00002,ko01000,ko01002,ko03110 - - - AAA,FtsH_ext,Peptidase_M41 k59_104540_1 1484460.JSWG01000009_gene317 4.9e-50 181.0 COG2373@1|root,COG3291@1|root,COG2373@2|Bacteria,COG3291@2|Bacteria,4NDZQ@976|Bacteroidetes,1HX5A@117743|Flavobacteriia 976|Bacteroidetes M C-terminal domain of CHU protein family - - - - - - - - - - - - CHU_C,Cleaved_Adhesin,MAM,fn3 k59_1683684_1 648757.Rvan_0800 1.32e-47 171.0 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,2TQR7@28211|Alphaproteobacteria,3N6FY@45401|Hyphomicrobiaceae 28211|Alphaproteobacteria NT Four helix bundle sensory module for signal transduction mcrA - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - 4HB_MCP_1,HAMP,MCPsignal k59_1575640_1 1229909.NSED_09175 8.85e-50 165.0 arCOG10600@1|root,arCOG10600@2157|Archaea,41T8K@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_897312_1 158500.BV97_03222 3.55e-89 269.0 COG0685@1|root,COG0685@2|Bacteria,1MUC9@1224|Proteobacteria,2TQZA@28211|Alphaproteobacteria,2K03Q@204457|Sphingomonadales 204457|Sphingomonadales E Methylenetetrahydrofolate reductase metF - 1.5.1.20 ko:K00297 ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,map00670,map00720,map01100,map01120,map01200,map01523 M00377 R01224,R07168 RC00081 ko00000,ko00001,ko00002,ko01000 - - - MTHFR k59_1117891_1 298655.KI912266_gene4712 1.97e-51 170.0 COG1028@1|root,COG1028@2|Bacteria,2IBHM@201174|Actinobacteria,4EVGV@85013|Frankiales 201174|Actinobacteria IQ Enoyl-(Acyl carrier protein) reductase - - - - - - - - - - - - adh_short_C2 k59_1793182_1 391625.PPSIR1_10610 2.3e-56 194.0 COG0441@1|root,COG0441@2|Bacteria,1MUP2@1224|Proteobacteria,42M20@68525|delta/epsilon subdivisions,2WJ2N@28221|Deltaproteobacteria,2YWDH@29|Myxococcales 28221|Deltaproteobacteria J Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr) thrS - 6.1.1.3 ko:K01868 ko00970,map00970 M00359,M00360 R03663 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - HGTP_anticodon,TGS,tRNA-synt_2b,tRNA_SAD k59_550921_1 1294143.H681_08195 6.72e-16 82.8 COG2304@1|root,COG2931@1|root,COG2304@2|Bacteria,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,1RNK8@1236|Gammaproteobacteria 1236|Gammaproteobacteria Q COG2931 RTX toxins and related Ca2 -binding proteins - - - - - - - - - - - - He_PIG,HemolysinCabind,VWA_2 k59_1065063_1 309801.trd_1265 1.65e-41 149.0 COG0568@1|root,COG0568@2|Bacteria,2G5W3@200795|Chloroflexi,27Y3K@189775|Thermomicrobia 189775|Thermomicrobia K Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released - - - ko:K03086 - - - - ko00000,ko03021 - - - Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4 k59_439821_1 314285.KT71_11064 4.46e-84 264.0 COG2211@1|root,COG2211@2|Bacteria,1MVUM@1224|Proteobacteria,1RP5J@1236|Gammaproteobacteria,1J7ES@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria G MFS/sugar transport protein ynaJ - - ko:K03292 - - - - ko00000 2.A.2 - - MFS_2 k59_897325_1 1116472.MGMO_155c00090 3.26e-49 167.0 COG0126@1|root,COG0126@2|Bacteria,1MUNU@1224|Proteobacteria,1RMUQ@1236|Gammaproteobacteria,1XDUK@135618|Methylococcales 135618|Methylococcales F Belongs to the phosphoglycerate kinase family pgk - 2.7.2.3 ko:K00927 ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01512 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000,ko04147 - - - PGK k59_897325_2 1380358.JADJ01000027_gene1640 7.67e-20 88.6 COG0469@1|root,COG0469@2|Bacteria,1MU21@1224|Proteobacteria,1RMW3@1236|Gammaproteobacteria,1XHFK@135619|Oceanospirillales 135619|Oceanospirillales G Belongs to the pyruvate kinase family - - 2.7.1.40 ko:K00873 ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230 M00001,M00002,M00049,M00050 R00200,R00430,R01138,R01858,R02320 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - PK,PK_C k59_1456790_1 323261.Noc_2865 2.44e-33 130.0 COG0770@1|root,COG0770@2|Bacteria,1QTSF@1224|Proteobacteria,1RMGD@1236|Gammaproteobacteria,1WWTC@135613|Chromatiales 135613|Chromatiales M Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein murF - 6.3.2.10 ko:K01929 ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502 - R04573,R04617 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_1003720_1 1502850.FG91_01001 1.02e-10 62.0 COG1904@1|root,COG1904@2|Bacteria,1MVRI@1224|Proteobacteria,2TS93@28211|Alphaproteobacteria,2JZWP@204457|Sphingomonadales 204457|Sphingomonadales G glucuronate isomerase uxaC - 5.3.1.12 ko:K01812 ko00040,ko01100,map00040,map01100 M00061,M00631 R01482,R01983 RC00376 ko00000,ko00001,ko00002,ko01000 - - - UxaC k59_1003720_2 392499.Swit_1891 2.59e-66 211.0 COG2186@1|root,COG2186@2|Bacteria,1MY1K@1224|Proteobacteria,2U5AC@28211|Alphaproteobacteria,2KCRW@204457|Sphingomonadales 204457|Sphingomonadales K FCD - - - ko:K05799 - - - - ko00000,ko03000 - - - FCD,GntR k59_1232569_1 506534.Rhein_0404 8.39e-58 189.0 COG1638@1|root,COG1638@2|Bacteria,1MVHC@1224|Proteobacteria,1RPNJ@1236|Gammaproteobacteria,1X2E3@135613|Chromatiales 135613|Chromatiales G Bacterial extracellular solute-binding protein, family 7 - - - - - - - - - - - - DctP k59_1232571_1 667632.KB890209_gene5319 2.01e-82 266.0 COG2114@1|root,COG4252@1|root,COG2114@2|Bacteria,COG4252@2|Bacteria,1MV1V@1224|Proteobacteria,2VJ72@28216|Betaproteobacteria,1K6DP@119060|Burkholderiaceae 28216|Betaproteobacteria T Chase2 domain cyaA - 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 - - - CHASE2,Guanylate_cyc k59_1456799_1 511062.GU3_04200 6.75e-10 58.5 COG1463@1|root,COG1463@2|Bacteria,1NCUG@1224|Proteobacteria,1RQ0Y@1236|Gammaproteobacteria,1Y4E3@135624|Aeromonadales 135624|Aeromonadales Q MlaD protein - - - ko:K02067 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - MlaD k59_1456799_2 589865.DaAHT2_1300 6.02e-17 80.5 COG0767@1|root,COG0767@2|Bacteria,1MVPN@1224|Proteobacteria,42MR1@68525|delta/epsilon subdivisions,2WKC9@28221|Deltaproteobacteria,2MJIH@213118|Desulfobacterales 28221|Deltaproteobacteria Q Permease MlaE - - - ko:K02066 ko02010,map02010 M00210,M00669,M00670 - - ko00000,ko00001,ko00002,ko02000 3.A.1.27 - - MlaE k59_1117907_1 523791.Kkor_1492 1.53e-98 295.0 COG0022@1|root,COG0022@2|Bacteria,1R8KB@1224|Proteobacteria,1RP3G@1236|Gammaproteobacteria,1XHJM@135619|Oceanospirillales 135619|Oceanospirillales C Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit - - 1.2.4.1 ko:K00162 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230 M00307 R00014,R00209,R01699,R03270 RC00004,RC00027,RC00627,RC02742,RC02744,RC02882 br01601,ko00000,ko00001,ko00002,ko01000 - - - Transket_pyr,Transketolase_C k59_158987_1 1121479.AUBS01000041_gene658 3.17e-69 227.0 COG0055@1|root,COG0055@2|Bacteria,1N6UZ@1224|Proteobacteria,2TT70@28211|Alphaproteobacteria 28211|Alphaproteobacteria C Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits atpD_2 - 3.6.3.14 ko:K02112 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - - ATP-synt_ab,ATP-synt_ab_N k59_158993_1 926549.KI421517_gene1259 1.13e-68 218.0 COG0656@1|root,COG0656@2|Bacteria,4NK47@976|Bacteroidetes,47MZY@768503|Cytophagia 976|Bacteroidetes S Aldo/keto reductase family - - - - - - - - - - - - Aldo_ket_red k59_158993_2 381666.H16_B1130 3.52e-16 78.2 COG0665@1|root,COG0665@2|Bacteria,1MXD1@1224|Proteobacteria,2VKJ5@28216|Betaproteobacteria,1K0VS@119060|Burkholderiaceae 28216|Betaproteobacteria E fad dependent oxidoreductase - - 1.4.99.6 ko:K19746 ko00472,ko01100,map00472,map01100 - R11018 RC00006 ko00000,ko00001,ko01000 - - - DAO k59_836966_1 589924.Ferp_1586 1.84e-35 129.0 COG0863@1|root,arCOG00115@2157|Archaea,2XT30@28890|Euryarchaeota,246GU@183980|Archaeoglobi 183980|Archaeoglobi L DNA methylase - - 2.1.1.113 ko:K00590 - - - - ko00000,ko01000,ko02048 - - - N6_N4_Mtase k59_836966_2 1120980.JQKH01000019_gene2299 9.76e-14 72.4 COG3004@1|root,COG3004@2|Bacteria,1MW15@1224|Proteobacteria,2VIPV@28216|Betaproteobacteria,2KRFW@206351|Neisseriales 206351|Neisseriales P Na+/H+ antiporter 1 - - - ko:K03313 - - - - ko00000,ko02000 2.A.33.1 - - Na_H_antiport_1 k59_1518289_1 1501230.ET33_10595 1.28e-22 98.2 COG1285@1|root,COG1285@2|Bacteria,1V409@1239|Firmicutes,4HC2G@91061|Bacilli,26R4Z@186822|Paenibacillaceae 91061|Bacilli S MgtC SapB transporter sapB - - ko:K07507 - - - - ko00000,ko02000 9.B.20 - - MgtC k59_1518290_1 1415778.JQMM01000001_gene48 1.25e-135 397.0 COG1190@1|root,COG1190@2|Bacteria,1MX1V@1224|Proteobacteria,1RMJN@1236|Gammaproteobacteria,1J4CY@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria J Belongs to the class-II aminoacyl-tRNA synthetase family lysS GO:0003674,GO:0003824,GO:0004812,GO:0004824,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006430,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576 6.1.1.6 ko:K04567 ko00970,map00970 M00359,M00360 R03658 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - tRNA-synt_2,tRNA_anti-codon k59_104583_1 865937.Gilli_2348 2.91e-07 58.2 COG0745@1|root,COG2202@1|root,COG3290@1|root,COG3829@1|root,COG4251@1|root,COG0745@2|Bacteria,COG2202@2|Bacteria,COG3290@2|Bacteria,COG3829@2|Bacteria,COG4251@2|Bacteria,4NFC3@976|Bacteroidetes 976|Bacteroidetes T Pfam Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg k59_727270_1 1161401.ASJA01000004_gene2233 1.1e-19 89.7 COG0739@1|root,COG0739@2|Bacteria,1RK7E@1224|Proteobacteria,2UB7B@28211|Alphaproteobacteria 28211|Alphaproteobacteria M COG0739 Membrane proteins related to metalloendopeptidases - - - ko:K21472 - - - - ko00000,ko01000,ko01002,ko01011 - - - Peptidase_M23 k59_1117926_1 404380.Gbem_1581 2.21e-47 158.0 COG2318@1|root,COG2318@2|Bacteria 2|Bacteria S DinB family ywlC1 - - - - - - - - - - - DinB_2 k59_159017_1 675806.VII_000805 3.24e-09 63.2 COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,1RMH0@1236|Gammaproteobacteria,1XSMX@135623|Vibrionales 135623|Vibrionales NT methyl-accepting chemotaxis protein - - - ko:K03406 ko02020,ko02030,map02020,map02030 - - - ko00000,ko00001,ko02035 - - - HAMP,MCPsignal k59_1065112_1 765912.Thimo_0554 1.88e-31 114.0 COG1610@1|root,COG1610@2|Bacteria,1RGZS@1224|Proteobacteria,1S61A@1236|Gammaproteobacteria,1WYDV@135613|Chromatiales 135613|Chromatiales S Yqey-like protein - - - ko:K09117 - - - - ko00000 - - - YqeY k59_1065112_2 87626.PTD2_13474 6.83e-27 99.8 COG0828@1|root,COG0828@2|Bacteria,1MZCC@1224|Proteobacteria,1S8QZ@1236|Gammaproteobacteria,2Q31X@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria J Belongs to the bacterial ribosomal protein bS21 family rpsU GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02970 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S21 k59_1065112_3 1082705.JIBP01000002_gene1986 7.66e-08 52.4 COG0533@1|root,COG0533@2|Bacteria,1MU6S@1224|Proteobacteria,1RN8M@1236|Gammaproteobacteria 1236|Gammaproteobacteria J Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction tsaD GO:0000287,GO:0000408,GO:0002949,GO:0003674,GO:0003824,GO:0004175,GO:0004222,GO:0005488,GO:0005506,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006508,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0019538,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0070011,GO:0070525,GO:0071704,GO:0090304,GO:0140030,GO:0140032,GO:0140096,GO:1901360,GO:1901564 2.3.1.234 ko:K01409 - - R10648 RC00070,RC00416 ko00000,ko01000,ko03016 - - - Peptidase_M22 k59_48632_1 1144305.PMI02_03647 1.99e-206 578.0 COG0174@1|root,COG0174@2|Bacteria,1MUGQ@1224|Proteobacteria,2TSCR@28211|Alphaproteobacteria,2K06N@204457|Sphingomonadales 204457|Sphingomonadales E highly regulated protein controlled by the addition removal of adenylyl groups by adenylyltransferase from specific tyrosine residues glnA - 6.3.1.2 ko:K01915 ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727 - R00253 RC00010,RC02798 ko00000,ko00001,ko01000,ko04147 - - - Gln-synt_C,Gln-synt_N k59_1740917_3 436308.Nmar_1331 8.96e-32 118.0 COG1475@1|root,arCOG01875@2157|Archaea 2157|Archaea K PFAM ParB domain protein nuclease - - - ko:K03497 - - - - ko00000,ko03000,ko03036,ko04812 - - - ParBc k59_1117939_1 983920.Y88_3034 9.66e-96 281.0 COG0233@1|root,COG0233@2|Bacteria,1N66T@1224|Proteobacteria,2U5B2@28211|Alphaproteobacteria,2K00Z@204457|Sphingomonadales 204457|Sphingomonadales J Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another frr - - ko:K02838 - - - - ko00000,ko03012 - - - RRF k59_1117939_2 1122612.AUBA01000011_gene791 1.58e-20 87.4 COG0528@1|root,COG0528@2|Bacteria,1MV3N@1224|Proteobacteria,2TQYN@28211|Alphaproteobacteria,2K1B1@204457|Sphingomonadales 204457|Sphingomonadales F Catalyzes the reversible phosphorylation of UMP to UDP pyrH - 2.7.4.22 ko:K09903 ko00240,ko01100,map00240,map01100 - R00158 RC00002 ko00000,ko00001,ko01000 - - - AA_kinase k59_495356_1 1120951.AUBG01000003_gene2765 1.09e-40 149.0 COG2207@1|root,COG3063@1|root,COG5616@1|root,COG2207@2|Bacteria,COG3063@2|Bacteria,COG5616@2|Bacteria,4NFW7@976|Bacteroidetes,1HZQR@117743|Flavobacteriia 976|Bacteroidetes K COGs COG5616 integral membrane protein - - - - - - - - - - - - ANAPC3,HTH_18,TPR_2,TPR_8 k59_1003774_1 1122194.AUHU01000016_gene1872 1.57e-102 306.0 COG1062@1|root,COG1062@2|Bacteria,1MUK4@1224|Proteobacteria,1RNQ4@1236|Gammaproteobacteria,4644Q@72275|Alteromonadaceae 1236|Gammaproteobacteria C Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily adhC - 1.1.1.1,1.1.1.284 ko:K00121 ko00010,ko00071,ko00350,ko00625,ko00626,ko00680,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,ko05204,map00010,map00071,map00350,map00625,map00626,map00680,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01200,map01220,map05204 - R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R06983,R07105,R08281,R08306,R08310 RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01715,RC01734,RC02273 ko00000,ko00001,ko01000 - - - ADH_N,ADH_zinc_N k59_1177533_1 1415778.JQMM01000001_gene1650 1.6e-130 389.0 COG1570@1|root,COG1570@2|Bacteria,1MUA4@1224|Proteobacteria,1RNAZ@1236|Gammaproteobacteria,1J4IC@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides xseA GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006308,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008855,GO:0009056,GO:0009057,GO:0009318,GO:0009987,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0019439,GO:0032991,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901361,GO:1901575,GO:1902494 3.1.11.6 ko:K03601 ko03430,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - Exonuc_VII_L,tRNA_anti_2 k59_778378_1 1229909.NSED_09625 4.25e-79 242.0 arCOG08041@1|root,arCOG08041@2157|Archaea,41SRT@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - HTH_27 k59_1004665_1 498211.CJA_0170 8.41e-47 175.0 COG4225@1|root,COG4225@2|Bacteria,1MU2J@1224|Proteobacteria,1RR65@1236|Gammaproteobacteria,1FFXX@10|Cellvibrio 1236|Gammaproteobacteria S Glycosyl Hydrolase Family 88 - - - - - - - - - - - - DUF4861,Glyco_hydro_88 k59_1794140_1 1121948.AUAC01000004_gene127 4.72e-71 226.0 COG3420@1|root,COG3420@2|Bacteria,1QUPB@1224|Proteobacteria,2TTFV@28211|Alphaproteobacteria,4414Y@69657|Hyphomonadaceae 28211|Alphaproteobacteria P Periplasmic copper-binding protein (NosD) - - - - - - - - - - - - Beta_helix k59_1741786_1 1122135.KB893134_gene3963 3.19e-62 208.0 COG2303@1|root,COG2303@2|Bacteria,1MV19@1224|Proteobacteria,2TQKQ@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate - - 1.1.99.1 ko:K00108 ko00260,ko01100,map00260,map01100 M00555 R01025 RC00087 ko00000,ko00001,ko00002,ko01000 - - - GMC_oxred_C,GMC_oxred_N k59_667165_2 1236542.BALM01000026_gene1953 2.97e-128 379.0 COG0001@1|root,COG0001@2|Bacteria,1MUY5@1224|Proteobacteria,1SM2G@1236|Gammaproteobacteria,2QAAP@267890|Shewanellaceae 1236|Gammaproteobacteria H Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family - - 5.4.3.8 ko:K01845 ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120 M00121 R02272 RC00677 ko00000,ko00001,ko00002,ko01000,ko01007 - - - Aminotran_3 k59_496247_1 1205680.CAKO01000042_gene5367 4.75e-112 336.0 COG3119@1|root,COG3119@2|Bacteria,1MUJH@1224|Proteobacteria,2TSB8@28211|Alphaproteobacteria 28211|Alphaproteobacteria P arylsulfatase A - - 3.1.6.1 ko:K01130 ko00140,ko00600,map00140,map00600 - R03980,R04856 RC00128,RC00231 ko00000,ko00001,ko01000 - - - DUF4994,Sulfatase,Sulfatase_C k59_1177570_1 420662.Mpe_A1208 4.46e-33 128.0 COG4235@1|root,COG4235@2|Bacteria,1MY4J@1224|Proteobacteria,2VQ05@28216|Betaproteobacteria,1KKAY@119065|unclassified Burkholderiales 28216|Betaproteobacteria O Cytochrome c-type biogenesis protein cycH - - ko:K02200 - - - - ko00000 - - - TPR_16,TPR_2 k59_728246_1 316407.1742423 2.02e-18 82.0 COG4608@1|root,COG4608@2|Bacteria,1NU4K@1224|Proteobacteria,1RRVT@1236|Gammaproteobacteria 1236|Gammaproteobacteria P Belongs to the ABC transporter superfamily ddpF - - ko:K02032 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - iEC042_1314.EC042_1615,iECH74115_1262.ECH74115_2095,iECSP_1301.ECSP_1968,iECUMN_1333.ECUMN_1737,iECW_1372.ECW_m1611,iECs_1301.ECs2087,iEKO11_1354.EKO11_2337,iWFL_1372.ECW_m1611,iZ_1308.Z2227 ABC_tran,oligo_HPY k59_728246_2 316407.1742424 9.11e-124 358.0 COG0444@1|root,COG0444@2|Bacteria,1R4KB@1224|Proteobacteria,1SMBI@1236|Gammaproteobacteria,3XMHZ@561|Escherichia 1236|Gammaproteobacteria P Belongs to the ABC transporter superfamily ddpD GO:0000166,GO:0003674,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008144,GO:0008150,GO:0015232,GO:0015886,GO:0016020,GO:0017076,GO:0022857,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044464,GO:0051179,GO:0051181,GO:0051184,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901678 - ko:K02031,ko:K12371,ko:K15583 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00239,M00324,M00439 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 - iECIAI1_1343.ECIAI1_1494,iSBO_1134.SBO_1821 ABC_tran,oligo_HPY k59_1741801_1 998674.ATTE01000001_gene944 6.81e-27 113.0 COG2303@1|root,COG2303@2|Bacteria,1MV19@1224|Proteobacteria,1RMD2@1236|Gammaproteobacteria 1236|Gammaproteobacteria E Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate - - 1.1.99.1 ko:K00108 ko00260,ko01100,map00260,map01100 M00555 R01025 RC00087 ko00000,ko00001,ko00002,ko01000 - - - GMC_oxred_C,GMC_oxred_N k59_332814_1 290402.Cbei_1024 0.00068 48.1 COG2333@1|root,COG2333@2|Bacteria,1TS9U@1239|Firmicutes,249VR@186801|Clostridia,36DFY@31979|Clostridiaceae 186801|Clostridia L domain protein - - - ko:K02238 - M00429 - - ko00000,ko00002,ko02044 3.A.11.1,3.A.11.2 - - Ada_Zn_binding,Lactamase_B k59_1177576_1 656024.FsymDg_1262 3.44e-39 144.0 COG2801@1|root,COG2963@1|root,COG2801@2|Bacteria,COG2963@2|Bacteria,2IDYA@201174|Actinobacteria 201174|Actinobacteria L PFAM Transposase IS3 IS911 - - - ko:K07497 - - - - ko00000 - - - HTH_21,HTH_Tnp_1,rve,rve_3 k59_49589_2 870187.Thini_3190 6.36e-27 106.0 COG1194@1|root,COG1194@2|Bacteria,1MUD4@1224|Proteobacteria,1RMBT@1236|Gammaproteobacteria,460AU@72273|Thiotrichales 72273|Thiotrichales L TIGRFAM A G-specific adenine glycosylase - - - ko:K03575 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - EndIII_4Fe-2S,HhH-GPD,NUDIX_4 k59_728253_1 309807.SRU_1300 1.72e-71 235.0 COG0443@1|root,COG0443@2|Bacteria,4NERF@976|Bacteroidetes,1FIYW@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes O Hsp70 protein dnaK - - ko:K04043 ko03018,ko04212,ko05152,map03018,map04212,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 1.A.33.1 - - HSP70 k59_1177584_1 1464048.JNZS01000020_gene2256 1.55e-38 143.0 COG1409@1|root,COG1409@2|Bacteria,2IM97@201174|Actinobacteria,4D9VR@85008|Micromonosporales 201174|Actinobacteria S Calcineurin-like phosphoesterase - - 3.1.3.1 ko:K01077 ko00730,ko00790,ko01100,ko02020,map00730,map00790,map01100,map02020 M00126 R02135,R04620 RC00017 ko00000,ko00001,ko00002,ko00537,ko01000,ko04147 - - - Metallophos k59_159926_1 1250005.PHEL85_2048 6.46e-83 258.0 COG1349@1|root,COG3177@1|root,COG1349@2|Bacteria,COG3177@2|Bacteria,4NFBY@976|Bacteroidetes,1I0FS@117743|Flavobacteriia 976|Bacteroidetes K Fic/DOC family - - - - - - - - - - - - Fic,HTH_DeoR k59_159926_2 1484460.JSWG01000009_gene458 6.01e-48 154.0 COG3695@1|root,COG3695@2|Bacteria,4NQ34@976|Bacteroidetes,1I2Y7@117743|Flavobacteriia 976|Bacteroidetes L Cysteine methyltransferase ogt - 2.1.1.63 ko:K00567,ko:K07443 - - - - ko00000,ko01000,ko03400 - - - DNA_binding_1 k59_1344218_2 1088721.NSU_1977 3.15e-63 196.0 COG0824@1|root,COG0824@2|Bacteria,1N06V@1224|Proteobacteria,2UCAQ@28211|Alphaproteobacteria,2K5A4@204457|Sphingomonadales 204457|Sphingomonadales S thioesterase - - - ko:K07107 - - - - ko00000,ko01000 - - - Acyl-ACP_TE k59_1344218_3 983920.Y88_2966 4.8e-50 174.0 COG1770@1|root,COG1770@2|Bacteria,1MUED@1224|Proteobacteria,2TTR0@28211|Alphaproteobacteria,2K19E@204457|Sphingomonadales 204457|Sphingomonadales E peptidase S9 ptrB - 3.4.21.83 ko:K01354 ko05142,ko05143,map05142,map05143 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_S9,Peptidase_S9_N k59_332825_1 1397527.Q670_01620 1.65e-27 115.0 COG4796@1|root,COG4796@2|Bacteria,1QTT6@1224|Proteobacteria,1RN3Z@1236|Gammaproteobacteria,1XHZK@135619|Oceanospirillales 135619|Oceanospirillales U Type II and III secretion system protein pilQ - - ko:K02507,ko:K02666 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - AMIN,STN,Secretin,Secretin_N k59_1457689_1 948106.AWZT01000002_gene6149 2.81e-16 77.8 COG0318@1|root,COG0318@2|Bacteria,1MUMC@1224|Proteobacteria,2VGZE@28216|Betaproteobacteria,1K0Q2@119060|Burkholderiaceae 28216|Betaproteobacteria IQ PFAM AMP-dependent synthetase and ligase alkK - 6.2.1.44 ko:K20034 ko00920,map00920 - R10820 RC00004,RC00014 ko00000,ko00001,ko01000 - - - AMP-binding,AMP-binding_C k59_1457689_2 1151061.CAJY01000025_gene3864 0.000778 46.2 COG0745@1|root,COG0745@2|Bacteria,2GP1I@201174|Actinobacteria 201174|Actinobacteria T response regulator, receiver vicR - - - - - - - - - - - Response_reg,Trans_reg_C k59_389979_1 1004149.AFOE01000025_gene3217 1.18e-07 55.5 COG2207@1|root,COG2207@2|Bacteria,4NGS3@976|Bacteroidetes,1HYVE@117743|Flavobacteriia 976|Bacteroidetes K AraC-like ligand binding domain - - - - - - - - - - - - AraC_binding,HTH_18,HTH_AraC k59_389979_2 4787.PITG_10287T0 4.22e-31 127.0 COG2114@1|root,2QPPT@2759|Eukaryota,3Q8X8@4776|Peronosporales 4776|Peronosporales T Adenylate cyclase - - 4.6.1.1 ko:K11265 ko00230,ko04024,ko04371,ko04713,ko04714,map00230,map04024,map04371,map04713,map04714 - R00089,R00434 RC00295 ko00000,ko00001,ko01000 - - - FYVE,Guanylate_cyc,PH k59_845158_1 1128912.GMES_2134 1.45e-105 321.0 COG1283@1|root,COG1283@2|Bacteria,1MUDE@1224|Proteobacteria,1S1YQ@1236|Gammaproteobacteria,46DG4@72275|Alteromonadaceae 1236|Gammaproteobacteria P Na+/Pi-cotransporter yjbB - - ko:K03324 - - - - ko00000,ko02000 2.A.58.2 - - Na_Pi_cotrans,PhoU k59_1464756_1 1454004.AW11_02488 2.22e-50 172.0 COG0394@1|root,COG0704@1|root,COG0394@2|Bacteria,COG0704@2|Bacteria 2|Bacteria P negative regulation of phosphate transmembrane transport phoU GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009892,GO:0010563,GO:0010966,GO:0019220,GO:0019222,GO:0031323,GO:0031324,GO:0032879,GO:0034762,GO:0034763,GO:0034765,GO:0034766,GO:0042802,GO:0042803,GO:0043269,GO:0043271,GO:0044070,GO:0044424,GO:0044464,GO:0045936,GO:0046983,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051049,GO:0051051,GO:0051174,GO:0065007,GO:1903792,GO:1903795,GO:1903796,GO:1903959,GO:1903960,GO:2000185,GO:2000186 1.20.4.1,3.1.3.48 ko:K01104,ko:K02039,ko:K03741 - - - - ko00000,ko01000 - - - PhoU k59_1351011_2 436308.Nmar_1761 4.34e-97 288.0 COG1878@1|root,arCOG02462@2157|Archaea,41SK8@651137|Thaumarchaeota 651137|Thaumarchaeota E Putative cyclase - - - - - - - - - - - - Cyclase k59_1240371_1 1279017.AQYJ01000021_gene2855 1.33e-78 249.0 COG2972@1|root,COG2972@2|Bacteria,1MXVQ@1224|Proteobacteria,1RQDA@1236|Gammaproteobacteria,465PG@72275|Alteromonadaceae 1236|Gammaproteobacteria T Histidine kinase yesM - 2.7.13.3 ko:K08082 ko02020,map02020 M00493 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,His_kinase k59_1691709_1 1123279.ATUS01000003_gene569 1.84e-15 78.2 COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,1RMWA@1236|Gammaproteobacteria,1J52C@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria F DEAD-box RNA helicase involved in various cellular processes at low temperature, including ribosome biogenesis, mRNA degradation and translation initiation deaD GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003724,GO:0003725,GO:0003727,GO:0003824,GO:0004004,GO:0004386,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006401,GO:0006417,GO:0006725,GO:0006807,GO:0006950,GO:0006996,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009056,GO:0009057,GO:0009266,GO:0009314,GO:0009409,GO:0009628,GO:0009889,GO:0009891,GO:0009892,GO:0009893,GO:0009894,GO:0009895,GO:0009987,GO:0010468,GO:0010501,GO:0010556,GO:0010557,GO:0010604,GO:0010605,GO:0010608,GO:0010628,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019219,GO:0019222,GO:0019439,GO:0022607,GO:0022613,GO:0022618,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031328,GO:0031329,GO:0031330,GO:0032268,GO:0032270,GO:0033554,GO:0033592,GO:0034248,GO:0034250,GO:0034622,GO:0034641,GO:0034655,GO:0042254,GO:0042255,GO:0042273,GO:0042623,GO:0043170,GO:0043487,GO:0043488,GO:0043489,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0045727,GO:0045934,GO:0046483,GO:0046700,GO:0048255,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051173,GO:0051246,GO:0051247,GO:0051252,GO:0051253,GO:0051716,GO:0060255,GO:0061013,GO:0065003,GO:0065007,GO:0065008,GO:0070035,GO:0070417,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0080090,GO:0090304,GO:0097159,GO:0097617,GO:0140098,GO:1901360,GO:1901361,GO:1901363,GO:1901575,GO:1902369,GO:1902373,GO:1903311,GO:1903312,GO:2000112 3.6.4.13 ko:K05592 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03009,ko03019 - - - DEAD,DEADboxA,DbpA,Helicase_C k59_1691709_2 231434.JQJH01000006_gene43 5.91e-07 50.4 COG2346@1|root,COG2346@2|Bacteria,1RH21@1224|Proteobacteria,2U6GH@28211|Alphaproteobacteria,3NB96@45404|Beijerinckiaceae 28211|Alphaproteobacteria S Bacterial-like globin - - - ko:K06886 - - - - ko00000 - - - Bac_globin k59_167040_2 400668.Mmwyl1_1718 1.27e-08 53.1 COG2991@1|root,COG2991@2|Bacteria,1NI0R@1224|Proteobacteria,1SGJF@1236|Gammaproteobacteria,1XM95@135619|Oceanospirillales 135619|Oceanospirillales S protein conserved in bacteria - - - ko:K05952 - - - - ko00000 - - - NqrM k59_167040_3 349521.HCH_02692 2.28e-35 130.0 COG1477@1|root,COG1477@2|Bacteria,1MW6K@1224|Proteobacteria,1RNMZ@1236|Gammaproteobacteria,1XHN2@135619|Oceanospirillales 135619|Oceanospirillales H Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein apbE - 2.7.1.180 ko:K03734 - - - - ko00000,ko01000 - - - ApbE k59_1351034_1 1122225.AULQ01000002_gene502 1.58e-19 89.0 COG4768@1|root,COG4768@2|Bacteria,4NIFH@976|Bacteroidetes,1HZJJ@117743|Flavobacteriia 976|Bacteroidetes S protein containing a divergent version of the methyl-accepting chemotaxis-like domain - - - - - - - - - - - - - k59_1351034_2 983544.Lacal_1212 1.8e-18 83.6 COG0423@1|root,COG0423@2|Bacteria,4NE1C@976|Bacteroidetes,1HX2K@117743|Flavobacteriia 976|Bacteroidetes J Belongs to the class-II aminoacyl-tRNA synthetase family glyQS - 6.1.1.14 ko:K01880 ko00970,map00970 M00359,M00360 R03654 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029 - - - HGTP_anticodon,tRNA-synt_2b k59_673921_1 85643.Tmz1t_1151 2.91e-31 123.0 COG0842@1|root,COG1129@1|root,COG0842@2|Bacteria,COG1129@2|Bacteria,1QTT9@1224|Proteobacteria,2WGGY@28216|Betaproteobacteria,2KVF7@206389|Rhodocyclales 206389|Rhodocyclales V ABC-type multidrug transport system, ATPase component - - - ko:K13926 - - - - ko00000 - - - ABC2_membrane_3,ABC_tran k59_673921_2 1267005.KB911259_gene4085 3.22e-127 377.0 COG0845@1|root,COG0845@2|Bacteria,1MUG6@1224|Proteobacteria,2TTRG@28211|Alphaproteobacteria,3N90C@45401|Hyphomicrobiaceae 28211|Alphaproteobacteria M HlyD family secretion protein - - - ko:K01993 - - - - ko00000 - - - Biotin_lipoyl_2,HlyD_3,HlyD_D23 k59_673921_3 1231190.NA8A_11680 5.98e-29 112.0 COG1309@1|root,COG1309@2|Bacteria,1NB71@1224|Proteobacteria,2UBX7@28211|Alphaproteobacteria,43PTX@69277|Phyllobacteriaceae 28211|Alphaproteobacteria K Bacterial regulatory proteins, tetR family - - - - - - - - - - - - TetR_N k59_1295149_2 264732.Moth_1489 5e-33 124.0 COG1273@1|root,COG1273@2|Bacteria,1TSY5@1239|Firmicutes,249R4@186801|Clostridia,42FJA@68295|Thermoanaerobacterales 186801|Clostridia L With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD ku - - ko:K10979 ko03450,map03450 - - - ko00000,ko00001,ko03400 - - - Ku k59_447791_1 158500.BV97_02324 6.03e-142 413.0 COG2239@1|root,COG2239@2|Bacteria,1MW24@1224|Proteobacteria,2TRWK@28211|Alphaproteobacteria,2K0AK@204457|Sphingomonadales 204457|Sphingomonadales P Acts as a magnesium transporter mgtE - - ko:K06213 - - - - ko00000,ko02000 1.A.26.1 - - CBS,MgtE,MgtE_N k59_1011463_1 105559.Nwat_2287 1.12e-07 52.4 COG2885@1|root,COG2885@2|Bacteria,1MYBP@1224|Proteobacteria,1RVRF@1236|Gammaproteobacteria,1WWRS@135613|Chromatiales 135613|Chromatiales M Belongs to the ompA family - - - - - - - - - - - - Gly-zipper_Omp,OmpA k59_1011463_2 62928.azo2815 9.68e-32 116.0 COG0219@1|root,COG0219@2|Bacteria,1RCY4@1224|Proteobacteria,2VR5W@28216|Betaproteobacteria,2KWB7@206389|Rhodocyclales 206389|Rhodocyclales J Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide trmL - 2.1.1.207 ko:K03216 - - - - ko00000,ko01000,ko03016 - - - SpoU_methylase k59_1748677_1 1313172.YM304_03920 3.41e-71 230.0 COG0142@1|root,COG0142@2|Bacteria,2GMB4@201174|Actinobacteria,4CMZ7@84992|Acidimicrobiia 84992|Acidimicrobiia H Polyprenyl synthetase - - 2.5.1.30 ko:K00805 ko00900,ko01110,map00900,map01110 - R09247 RC00279 ko00000,ko00001,ko01000,ko01006 - - - polyprenyl_synt k59_1295170_1 589865.DaAHT2_1033 2.74e-126 379.0 COG1154@1|root,COG1154@2|Bacteria,1MUSJ@1224|Proteobacteria,42M35@68525|delta/epsilon subdivisions,2WIX5@28221|Deltaproteobacteria,2MI30@213118|Desulfobacterales 28221|Deltaproteobacteria H Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) dxs - 2.2.1.7 ko:K01662 ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130 M00096 R05636 RC00032 ko00000,ko00001,ko00002,ko01000 - - - DXP_synthase_N,Transket_pyr,Transketolase_C k59_1801113_1 983545.Glaag_1876 7.97e-16 75.9 COG2908@1|root,COG2908@2|Bacteria,1N3U7@1224|Proteobacteria,1RP1X@1236|Gammaproteobacteria,466F4@72275|Alteromonadaceae 1236|Gammaproteobacteria S Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell lpxH GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0008758,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0019637,GO:0019897,GO:0019898,GO:0030145,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044425,GO:0044459,GO:0044464,GO:0046467,GO:0046493,GO:0046872,GO:0046914,GO:0071704,GO:0071944,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509 3.6.1.54 ko:K03269 ko00540,ko01100,map00540,map01100 M00060 R04549 RC00002 ko00000,ko00001,ko00002,ko01000,ko01005 - - iE2348C_1286.E2348C_0457 Metallophos,Metallophos_2 k59_1801113_2 1158146.KB907122_gene358 5.28e-49 160.0 COG0652@1|root,COG0652@2|Bacteria,1R9ZQ@1224|Proteobacteria,1S222@1236|Gammaproteobacteria,1WYD7@135613|Chromatiales 135613|Chromatiales O PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides - - 5.2.1.8 ko:K03767,ko:K03768 ko01503,ko04217,map01503,map04217 - - - ko00000,ko00001,ko01000,ko03110,ko04147 - - - Pro_isomerase k59_447805_1 1122137.AQXF01000003_gene2460 9.77e-264 736.0 COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,2TR1I@28211|Alphaproteobacteria 28211|Alphaproteobacteria EH COG0028 Thiamine pyrophosphate-requiring enzymes acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase ilvI - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_1691745_1 1122137.AQXF01000001_gene2948 7.86e-81 245.0 COG3382@1|root,COG3382@2|Bacteria,1N6A7@1224|Proteobacteria,2UJ4A@28211|Alphaproteobacteria 28211|Alphaproteobacteria S B3/4 domain - - - - - - - - - - - - B3_4 k59_1240422_1 498211.CJA_1101 1.22e-38 132.0 COG1393@1|root,COG1393@2|Bacteria,1MZ6S@1224|Proteobacteria,1S8TR@1236|Gammaproteobacteria,1FHHX@10|Cellvibrio 1236|Gammaproteobacteria P ArsC family yffB GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464 1.20.4.1 ko:K00537 - - - - ko00000,ko01000 - - - ArsC k59_1072995_1 675813.VIB_001375 8.48e-09 54.7 COG0491@1|root,COG0491@2|Bacteria,1MUDN@1224|Proteobacteria,1RMMG@1236|Gammaproteobacteria,1XU1B@135623|Vibrionales 135623|Vibrionales S COG0491 Zn-dependent hydrolases, including glyoxylases ycbL - - - - - - - - - - - Lactamase_B k59_1072995_2 948106.AWZT01000044_gene5969 6.59e-17 80.9 COG3483@1|root,COG3483@2|Bacteria,1MW68@1224|Proteobacteria,2VJG3@28216|Betaproteobacteria,1K2UU@119060|Burkholderiaceae 28216|Betaproteobacteria E Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety kynA GO:0003674,GO:0003824,GO:0004833,GO:0005488,GO:0006082,GO:0006139,GO:0006520,GO:0006568,GO:0006569,GO:0006576,GO:0006586,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009063,GO:0009072,GO:0009074,GO:0009108,GO:0009117,GO:0009165,GO:0009308,GO:0009310,GO:0009435,GO:0009987,GO:0016043,GO:0016053,GO:0016054,GO:0016491,GO:0016701,GO:0016702,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019441,GO:0019637,GO:0019674,GO:0019752,GO:0019805,GO:0020037,GO:0022607,GO:0034641,GO:0034654,GO:0042180,GO:0042402,GO:0042430,GO:0042436,GO:0042537,GO:0043436,GO:0043648,GO:0043650,GO:0043933,GO:0044085,GO:0044106,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0046218,GO:0046394,GO:0046395,GO:0046483,GO:0046496,GO:0046700,GO:0046874,GO:0046906,GO:0048037,GO:0051186,GO:0051188,GO:0051213,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055086,GO:0055114,GO:0065003,GO:0070189,GO:0071704,GO:0071840,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606 1.13.11.11 ko:K00453 ko00380,ko01100,map00380,map01100 M00038 R00678 RC00356 ko00000,ko00001,ko00002,ko01000 - - - Trp_dioxygenase k59_1184456_1 247634.GPB2148_1738 7.44e-60 192.0 COG1177@1|root,COG1177@2|Bacteria,1MVC5@1224|Proteobacteria,1RQB7@1236|Gammaproteobacteria,1J5T1@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E COG1177 ABC-type spermidine putrescine transport system, permease component II potI - - ko:K11074 ko02010,map02010 M00300 - - ko00000,ko00001,ko00002,ko02000 3.A.1.11.2 - - BPD_transp_1 k59_1184456_2 400668.Mmwyl1_3521 4.45e-81 249.0 COG1176@1|root,COG1176@2|Bacteria,1MVGM@1224|Proteobacteria,1RNNZ@1236|Gammaproteobacteria,1XHK5@135619|Oceanospirillales 135619|Oceanospirillales P binding-protein-dependent transport systems inner membrane component - - - ko:K11075 ko02010,map02010 M00300 - - ko00000,ko00001,ko00002,ko02000 3.A.1.11.2 - - BPD_transp_1 k59_224195_1 999141.GME_16097 3.04e-20 85.1 COG0848@1|root,COG0848@2|Bacteria,1MZ6M@1224|Proteobacteria,1S8RS@1236|Gammaproteobacteria,1XKER@135619|Oceanospirillales 135619|Oceanospirillales U Biopolymer transport protein tolR - - ko:K03560 - - - - ko00000,ko02000 1.A.30.2.2 - - ExbD k59_224195_2 1198232.CYCME_2169 4.56e-47 157.0 COG0811@1|root,COG0811@2|Bacteria,1NCWW@1224|Proteobacteria,1RMD4@1236|Gammaproteobacteria,460DQ@72273|Thiotrichales 72273|Thiotrichales U MotA TolQ ExbB proton channel - - - ko:K03562 ko01120,map01120 - - - ko00000,ko02000 1.A.30.2.2 - - MotA_ExbB k59_1073004_1 330214.NIDE3048 2.6e-59 187.0 COG3216@1|root,COG3216@2|Bacteria,3J1DC@40117|Nitrospirae 40117|Nitrospirae S Uncharacterized protein conserved in bacteria (DUF2062) - - - ko:K09928 - - - - ko00000 - - - DUF2062 k59_956074_1 472759.Nhal_1290 1.95e-31 127.0 COG1643@1|root,COG1643@2|Bacteria,1MUEQ@1224|Proteobacteria,1RMU1@1236|Gammaproteobacteria,1WWGW@135613|Chromatiales 135613|Chromatiales L TIGRFAM ATP-dependent helicase HrpA - - 3.6.4.13 ko:K03578 - - - - ko00000,ko01000 - - - DEAD,DUF3418,HA2,Helicase_C,OB_NTP_bind k59_1013120_1 1121904.ARBP01000018_gene2673 1.3e-19 85.5 COG3000@1|root,COG3000@2|Bacteria,4NI62@976|Bacteroidetes,47NVG@768503|Cytophagia 976|Bacteroidetes I Fatty acid hydroxylase superfamily - - - - - - - - - - - - FA_hydroxylase k59_1466472_1 370438.PTH_0149 2.11e-46 169.0 COG5421@1|root,COG5421@2|Bacteria,1TPAA@1239|Firmicutes,2492T@186801|Clostridia,261KM@186807|Peptococcaceae 186801|Clostridia L PFAM Transposase DDE domain - - - - - - - - - - - - DDE_Tnp_1 k59_675727_1 1121920.AUAU01000010_gene61 5.15e-101 301.0 COG0500@1|root,COG2226@2|Bacteria,3Y5HG@57723|Acidobacteria 57723|Acidobacteria Q Mycolic acid cyclopropane synthetase - - - - - - - - - - - - Methyltransf_11 k59_1750399_1 391615.ABSJ01000002_gene529 4.39e-52 179.0 COG1570@1|root,COG1570@2|Bacteria,1MUA4@1224|Proteobacteria,1RNAZ@1236|Gammaproteobacteria,1J4IC@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides xseA GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006308,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008855,GO:0009056,GO:0009057,GO:0009318,GO:0009987,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0019439,GO:0032991,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901361,GO:1901575,GO:1902494 3.1.11.6 ko:K03601 ko03430,map03430 - - - ko00000,ko00001,ko01000,ko03400 - - - Exonuc_VII_L,tRNA_anti_2 k59_675735_1 314231.FP2506_13264 0.000644 47.0 COG0745@1|root,COG0745@2|Bacteria,1MU3A@1224|Proteobacteria,2TR97@28211|Alphaproteobacteria,2PJ02@255475|Aurantimonadaceae 28211|Alphaproteobacteria K Transcriptional regulatory protein, C terminal mtrA - - - - - - - - - - - Response_reg,Trans_reg_C k59_449550_1 1313172.YM304_35550 1.74e-51 180.0 COG1007@1|root,COG1007@2|Bacteria,2GMGX@201174|Actinobacteria,4CMT6@84992|Acidimicrobiia 201174|Actinobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoN2 - 1.6.5.3 ko:K00343 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Proton_antipo_M k59_504707_1 1134474.O59_002262 1.27e-06 48.9 COG1476@1|root,COG1476@2|Bacteria,1N58S@1224|Proteobacteria,1T30H@1236|Gammaproteobacteria 1236|Gammaproteobacteria K Helix-turn-helix XRE-family like proteins - - - - - - - - - - - - HTH_31 k59_504707_2 1134474.O59_002263 4.31e-72 231.0 COG3550@1|root,COG3550@2|Bacteria,1N458@1224|Proteobacteria,1RMP7@1236|Gammaproteobacteria,1FGDV@10|Cellvibrio 1236|Gammaproteobacteria S Pfam:HipA_N - - 2.7.11.1 ko:K07154 - - - - ko00000,ko01000,ko01001,ko02048 - - - Couple_hipA,HipA_C k59_225988_1 158500.BV97_02920 1.85e-105 319.0 COG0642@1|root,COG2205@2|Bacteria,1RHIA@1224|Proteobacteria,2U9NA@28211|Alphaproteobacteria 28211|Alphaproteobacteria T His Kinase A (phosphoacceptor) domain - - 2.7.13.3 ko:K07645 ko02020,ko02024,map02020,map02024 M00453 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - 2CSK_N,HATPase_c,HisKA k59_560673_1 1122137.AQXF01000007_gene3503 3.68e-91 283.0 COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,2TSB1@28211|Alphaproteobacteria 28211|Alphaproteobacteria EH Belongs to the TPP enzyme family - - 2.2.1.6 ko:K01652 ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R00006,R00014,R00226,R03050,R04672,R04673,R08648 RC00027,RC00106,RC01192,RC02744,RC02893 ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_1127679_1 1288494.EBAPG3_25310 3.89e-35 126.0 2DTKB@1|root,33KR8@2|Bacteria,1NGWI@1224|Proteobacteria,2VY5N@28216|Betaproteobacteria,374CG@32003|Nitrosomonadales 28216|Betaproteobacteria U Type II secretion system protein C - - - ko:K02452 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - T2SSC k59_1127680_2 1131266.ARWQ01000014_gene87 1.86e-35 128.0 COG4122@1|root,arCOG00979@2157|Archaea,41SMF@651137|Thaumarchaeota 651137|Thaumarchaeota S O-methyltransferase - - - - - - - - - - - - Methyltransf_3 k59_1750440_1 1502850.FG91_00559 1.91e-29 122.0 COG4774@1|root,COG4774@2|Bacteria,1NMCN@1224|Proteobacteria,2TW4E@28211|Alphaproteobacteria,2K2TV@204457|Sphingomonadales 204457|Sphingomonadales P TonB dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_560695_1 383381.EH30_02615 6.6e-66 218.0 COG1020@1|root,COG1020@2|Bacteria,1N7HY@1224|Proteobacteria,2TRZV@28211|Alphaproteobacteria,2K46G@204457|Sphingomonadales 204457|Sphingomonadales Q Protein of unknown function (DUF1298) - - - - - - - - - - - - DUF1298,WES_acyltransf k59_1638227_1 481448.Minf_1288 8.96e-48 161.0 COG0602@1|root,COG0602@2|Bacteria,46SW0@74201|Verrucomicrobia,37GJK@326457|unclassified Verrucomicrobia 74201|Verrucomicrobia H Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds nrdG - 4.3.99.3 ko:K10026 ko00790,ko01100,map00790,map01100 - R10002 RC02989 ko00000,ko00001,ko01000,ko03016 - - - Fer4_14,Radical_SAM k59_957862_1 1121004.ATVC01000002_gene583 4.76e-25 108.0 COG3550@1|root,COG3550@2|Bacteria,1MW9U@1224|Proteobacteria,2VSWQ@28216|Betaproteobacteria 28216|Betaproteobacteria S HipA-like C-terminal domain - - 2.7.11.1 ko:K07154 - - - - ko00000,ko01000,ko01001,ko02048 - - - Couple_hipA,HipA_C k59_560708_2 1117315.AHCA01000001_gene2458 6.88e-53 182.0 28IAE@1|root,2Z8D0@2|Bacteria,1NC6U@1224|Proteobacteria,1RSEY@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_1296822_1 316407.1742793 7.85e-27 108.0 COG0072@1|root,COG0073@1|root,COG0072@2|Bacteria,COG0073@2|Bacteria,1MWKS@1224|Proteobacteria,1RMIH@1236|Gammaproteobacteria,3XMDP@561|Escherichia 1236|Gammaproteobacteria J phenylalanine-tRNA ligase activity pheT GO:0003674,GO:0003824,GO:0004812,GO:0004826,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0042802,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494 6.1.1.20 ko:K01890 ko00970,map00970 M00359,M00360 R03660 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - iG2583_1286.G2583_2160,iPC815.YPO2428 B3_4,B5,FDX-ACB,tRNA_bind k59_1013171_1 316407.85675365 9.75e-67 214.0 COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,1RNGU@1236|Gammaproteobacteria,3XMTM@561|Escherichia 1236|Gammaproteobacteria I Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed fadI GO:0003674,GO:0003824,GO:0003857,GO:0003988,GO:0004300,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016408,GO:0016491,GO:0016614,GO:0016616,GO:0016740,GO:0016746,GO:0016747,GO:0016829,GO:0016835,GO:0016836,GO:0019395,GO:0019752,GO:0030258,GO:0032787,GO:0033542,GO:0034440,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0055114,GO:0071704,GO:0072329,GO:1901575 2.3.1.16 ko:K00632 ko00071,ko00280,ko00281,ko00362,ko00592,ko00642,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00362,map00592,map00642,map01100,map01110,map01120,map01130,map01212 M00087,M00113 R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095 RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955 ko00000,ko00001,ko00002,ko01000 - - iECO103_1326.ECO103_2806,iEcHS_1320.EcHS_A2493 Thiolase_C,Thiolase_N k59_1013171_2 316407.1799732 1.48e-59 201.0 COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,1RMZ8@1236|Gammaproteobacteria,3XMJZ@561|Escherichia 1236|Gammaproteobacteria I Catalyzes the formation of a hydroxyacyl-CoA by addition of water on enoyl-CoA. Also exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities fadJ GO:0003674,GO:0003824,GO:0003857,GO:0004300,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0008692,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016491,GO:0016614,GO:0016616,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016854,GO:0016856,GO:0019395,GO:0019752,GO:0030258,GO:0032787,GO:0034440,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0046395,GO:0055114,GO:0071704,GO:0072329,GO:1901575 1.1.1.35,4.2.1.17,5.1.2.3 ko:K01782 ko00071,ko00280,ko00281,ko00310,ko00362,ko00380,ko00410,ko00640,ko00650,ko00903,ko00930,ko01040,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00362,map00380,map00410,map00640,map00650,map00903,map00930,map01040,map01100,map01110,map01120,map01130,map01200,map01212 M00032,M00087 R01975,R03026,R03045,R03276,R04137,R04170,R04203,R04204,R04224,R04737,R04738,R04739,R04740,R04741,R04744,R04745,R04746,R04748,R04749,R05066,R05305,R06411,R06412,R06941,R06942,R07935,R07951,R08093,R08094 RC00029,RC00099,RC00117,RC00241,RC00525,RC00831,RC00834,RC00896,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 - - iECABU_c1320.ECABU_c26730,iETEC_1333.ETEC_2476,iEcE24377_1341.EcE24377A_2637,ic_1306.c2886 3HCDH,3HCDH_N,ECH_1 k59_1013173_1 436308.Nmar_0315 2.83e-42 148.0 COG1577@1|root,arCOG01028@2157|Archaea,41SKC@651137|Thaumarchaeota 651137|Thaumarchaeota I Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids mvk - 2.7.1.36 ko:K00869 ko00900,ko01100,ko01110,ko01130,ko04146,map00900,map01100,map01110,map01130,map04146 M00095 R02245 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - GHMP_kinases_C,GHMP_kinases_N k59_1013173_2 436308.Nmar_0314 6.8e-28 106.0 COG1608@1|root,arCOG00860@2157|Archaea,41SI4@651137|Thaumarchaeota 651137|Thaumarchaeota I Amino acid kinase family - - 2.7.4.26 ko:K06981 ko00900,ko01110,ko01130,map00900,map01110,map01130 - R10093 RC00002 ko00000,ko00001,ko01000 - - - AA_kinase k59_1186063_1 316407.85676304 2.37e-149 432.0 COG0056@1|root,COG0056@2|Bacteria,1MUG7@1224|Proteobacteria,1RP4V@1236|Gammaproteobacteria,3XP3D@561|Escherichia 1236|Gammaproteobacteria F Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit atpA GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045261,GO:0045262,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 3.6.3.14 ko:K02111 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - iSbBS512_1146.SbBS512_E4187 ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N k59_1242320_1 1042376.AFPK01000013_gene62 5.23e-41 148.0 COG1929@1|root,COG1929@2|Bacteria,4NFK8@976|Bacteroidetes,1HXJ7@117743|Flavobacteriia 976|Bacteroidetes G Belongs to the glycerate kinase type-1 family glxK - 2.7.1.165 ko:K00865 ko00260,ko00561,ko00630,ko01100,ko01120,ko01130,map00260,map00561,map00630,map01100,map01120,map01130 - R08572 RC00002,RC00428 ko00000,ko00001,ko01000 - - - Gly_kinase k59_1242320_2 504487.JCM19302_371 3.64e-34 118.0 2E6VD@1|root,331EZ@2|Bacteria,4NUSW@976|Bacteroidetes,1I3VV@117743|Flavobacteriia 976|Bacteroidetes S Protein of unknown function (DUF3098) fjo13 - - - - - - - - - - - DUF3098 k59_1352996_1 761193.Runsl_0457 1.16e-82 266.0 COG3794@1|root,COG3794@2|Bacteria,4NG61@976|Bacteroidetes,47MGM@768503|Cytophagia 976|Bacteroidetes C PFAM blue (type 1) copper domain protein - - - - - - - - - - - - - k59_1242337_1 59538.XP_005974553.1 1.66e-10 65.9 COG0639@1|root,2S28V@2759|Eukaryota,39N7M@33154|Opisthokonta,3BVWV@33208|Metazoa,3DCVV@33213|Bilateria 33208|Metazoa T Calcineurin-like phosphoesterase - - - - - - - - - - - - Metallophos k59_1638277_1 1122137.AQXF01000001_gene3018 1.19e-108 325.0 COG2070@1|root,COG2070@2|Bacteria,1N52W@1224|Proteobacteria,2TV8B@28211|Alphaproteobacteria 28211|Alphaproteobacteria S 2-Nitropropane dioxygenase - - 1.13.12.16 ko:K00459 ko00910,map00910 - R00025 RC02541,RC02759 ko00000,ko00001,ko01000 - - - NMO k59_1802980_2 4922.CAY71499 7.87e-15 67.8 2EXMS@1|root,2SZ9G@2759|Eukaryota,3ATRW@33154|Opisthokonta,3PHYP@4751|Fungi,3R68N@4890|Ascomycota,3RWN9@4891|Saccharomycetes 4751|Fungi S identified by fungal homology comparisons and RT-PCR - - - - - - - - - - - - - k59_1638286_1 1122137.AQXF01000006_gene851 1.12e-113 343.0 COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2TW3C@28211|Alphaproteobacteria 28211|Alphaproteobacteria IQ COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II - - - ko:K00666 - - - - ko00000,ko01000,ko01004 - - - AMP-binding,AMP-binding_C_2,Acyltransferase,PP-binding k59_1802995_1 697303.Thewi_0412 2.53e-16 80.5 COG0803@1|root,COG0803@2|Bacteria,1TPG7@1239|Firmicutes,249VZ@186801|Clostridia,42F8Z@68295|Thermoanaerobacterales 186801|Clostridia P PFAM periplasmic solute binding protein adcA - - ko:K09815 ko02010,map02010 M00242 - - ko00000,ko00001,ko00002,ko02000 3.A.1.15.3,3.A.1.15.5 - iHN637.CLJU_RS18655 ZnuA k59_1802995_2 1229909.NSED_08965 5.4e-14 67.0 COG0864@1|root,arCOG01008@2157|Archaea,41SQM@651137|Thaumarchaeota 651137|Thaumarchaeota K Ribbon-helix-helix protein, copG family - - - ko:K07722 - - - - ko00000,ko03000 - - - NikR_C,RHH_1 k59_1186101_1 1120956.JHZK01000034_gene2050 4.38e-186 544.0 COG0129@1|root,COG0363@1|root,COG0129@2|Bacteria,COG0363@2|Bacteria,1MUTQ@1224|Proteobacteria,2TRTQ@28211|Alphaproteobacteria,1JNQ4@119043|Rhodobiaceae 28211|Alphaproteobacteria E Dehydratase family - - 4.2.1.82 ko:K22186 ko00040,map00040 - R02429 RC00543 ko00000,ko00001,ko01000 - - - ILVD_EDD k59_1296926_1 1207055.C100_16860 1.39e-104 315.0 COG0141@1|root,COG0141@2|Bacteria,1MUUF@1224|Proteobacteria,2TS04@28211|Alphaproteobacteria,2K1SZ@204457|Sphingomonadales 204457|Sphingomonadales E Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine - - 1.1.1.308 ko:K15509 - - - - ko00000,ko01000 - - - Histidinol_dh k59_1353064_1 1229780.BN381_130036 2.02e-105 319.0 COG0533@1|root,COG0533@2|Bacteria,2GJ98@201174|Actinobacteria,3UWA4@52018|unclassified Actinobacteria (class) 201174|Actinobacteria O Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction tsaD GO:0000408,GO:0002949,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:1901360 2.3.1.234 ko:K01409 - - R10648 RC00070,RC00416 ko00000,ko01000,ko03016 - - - Acetyltransf_1,Peptidase_M22 k59_1296930_1 502025.Hoch_3753 9.44e-42 160.0 COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,42Q0K@68525|delta/epsilon subdivisions,2WJUW@28221|Deltaproteobacteria,2YTVH@29|Myxococcales 28221|Deltaproteobacteria L DbpA RNA binding domain dedA - 3.6.4.13 ko:K03732,ko:K05592 ko03018,map03018 M00394 - - ko00000,ko00001,ko00002,ko01000,ko03009,ko03019 - - - DEAD,DbpA,Helicase_C k59_1296930_2 794903.OPIT5_07835 6.03e-138 402.0 COG0150@1|root,COG0150@2|Bacteria,46SJ4@74201|Verrucomicrobia,3K7F8@414999|Opitutae 414999|Opitutae F AIR synthase related protein, C-terminal domain - - 6.3.3.1 ko:K01933 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04208 RC01100 ko00000,ko00001,ko00002,ko01000 - - - AIRS,AIRS_C k59_787267_1 1160718.SU9_13508 2.39e-47 160.0 COG0590@1|root,COG0590@2|Bacteria,2IM3Z@201174|Actinobacteria 201174|Actinobacteria FJ Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2) tadA - 3.5.4.1,3.5.4.33 ko:K01485,ko:K11991 ko00240,ko00330,ko01100,map00240,map00330,map01100 - R00974,R01411,R02922,R10223 RC00074,RC00477,RC00514,RC00809 ko00000,ko00001,ko01000,ko03016 - - - MafB19-deam,dCMP_cyt_deam_1 k59_787267_2 1283299.AUKG01000001_gene3442 2.31e-26 102.0 2AY0M@1|root,31Q26@2|Bacteria,2IMBI@201174|Actinobacteria 201174|Actinobacteria S Phospholipase_D-nuclease N-terminal - - - - - - - - - - - - PLDc_N,SHOCT k59_1466689_1 1232410.KI421421_gene3272 1.19e-44 157.0 COG1924@1|root,COG1924@2|Bacteria,1R6HU@1224|Proteobacteria,42PM0@68525|delta/epsilon subdivisions,2X5NK@28221|Deltaproteobacteria,43W2S@69541|Desulfuromonadales 28221|Deltaproteobacteria I BadF/BadG/BcrA/BcrD ATPase family - - - - - - - - - - - - BcrAD_BadFG k59_1466689_2 1244869.H261_12286 3.97e-13 68.6 COG1775@1|root,COG1775@2|Bacteria,1NKED@1224|Proteobacteria,2U31W@28211|Alphaproteobacteria 28211|Alphaproteobacteria E benzoyl-CoA reductase - - 1.3.7.8 ko:K04113 ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220 M00541 R02451 RC00002,RC01839 ko00000,ko00001,ko00002,ko01000 - - - HGD-D k59_1532766_15 1538804.A0A088F6T3_9CAUD 1.34e-90 301.0 4QAKM@10239|Viruses,4QPEF@28883|Caudovirales,4QKNE@10699|Siphoviridae 10699|Siphoviridae S DNA polymerase family A - GO:0003674,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0006139,GO:0006259,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008408,GO:0009058,GO:0009059,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0071704,GO:0071897,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901362,GO:1901576 - - - - - - - - - - - k59_1532766_16 4432.XP_010263699.1 2.62e-29 113.0 COG0756@1|root,KOG3370@2759|Eukaryota,37TVP@33090|Viridiplantae,3GI4X@35493|Streptophyta 35493|Streptophyta F Deoxyuridine 5'-triphosphate - GO:0000287,GO:0003674,GO:0003824,GO:0004170,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006220,GO:0006221,GO:0006226,GO:0006244,GO:0006259,GO:0006281,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009141,GO:0009143,GO:0009147,GO:0009149,GO:0009157,GO:0009162,GO:0009165,GO:0009166,GO:0009176,GO:0009177,GO:0009200,GO:0009204,GO:0009211,GO:0009213,GO:0009219,GO:0009221,GO:0009223,GO:0009262,GO:0009263,GO:0009264,GO:0009265,GO:0009394,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0033554,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046078,GO:0046080,GO:0046081,GO:0046385,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0046872,GO:0047429,GO:0050896,GO:0051716,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0072529,GO:0090304,GO:0090407,GO:1901135,GO:1901136,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576 3.6.1.23 ko:K01520 ko00240,ko00983,ko01100,map00240,map00983,map01100 M00053 R02100,R11896 RC00002 ko00000,ko00001,ko00002,ko01000,ko03400 - - - dUTPase k59_628515_2 1122137.AQXF01000007_gene3561 2.9e-100 312.0 COG0296@1|root,COG0296@2|Bacteria,1QTVN@1224|Proteobacteria,2TR5K@28211|Alphaproteobacteria 28211|Alphaproteobacteria G Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position glgB - 2.4.1.18 ko:K00700 ko00500,ko01100,ko01110,map00500,map01100,map01110 M00565 R02110 - ko00000,ko00001,ko00002,ko01000,ko04147 - CBM48,GH13 - Alpha-amylase,Alpha-amylase_C,CBM_48 k59_120601_1 444875.E3SMH7_9CAUD 1.32e-07 55.1 4QAQV@10239|Viruses,4QUPK@35237|dsDNA viruses no RNA stage,4QPCB@28883|Caudovirales,4QNFC@10744|Podoviridae 10744|Podoviridae S hydrolase activity - - - - - - - - - - - - - k59_1080503_1 1123367.C666_13280 2.71e-26 110.0 COG1612@1|root,COG1612@2|Bacteria,1MVJ4@1224|Proteobacteria,2VJ3C@28216|Betaproteobacteria,2KVXZ@206389|Rhodocyclales 206389|Rhodocyclales O protein required for cytochrome oxidase assembly ctaA - - ko:K02259 ko00190,ko00860,ko01100,ko01110,ko02020,ko04714,map00190,map00860,map01100,map01110,map02020,map04714 M00154 R07412 RC00769 ko00000,ko00001,ko00002,ko03029 3.D.4.4 - - COX15-CtaA k59_232948_1 1415778.JQMM01000001_gene1070 1.47e-81 252.0 COG1703@1|root,COG1703@2|Bacteria,1MVI0@1224|Proteobacteria,1RP15@1236|Gammaproteobacteria,1J4Q4@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E periplasmic protein kinase ArgK and related GTPases of G3E family argK GO:0003674,GO:0003824,GO:0003924,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111 - ko:K07588 - - - - ko00000,ko01000 - - - ArgK k59_232948_2 1122137.AQXF01000002_gene126 8.88e-86 253.0 COG0346@1|root,COG0346@2|Bacteria,1RCYU@1224|Proteobacteria,2U728@28211|Alphaproteobacteria 28211|Alphaproteobacteria E methylmalonyl-CoA epimerase mce - 5.1.99.1 ko:K05606 ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200 M00373,M00375,M00376,M00741 R02765,R09979 RC00780,RC02739 ko00000,ko00001,ko00002,ko01000 - - - Glyoxalase_4 k59_232948_3 1132855.KB913035_gene1216 7.63e-15 73.6 COG0123@1|root,COG0123@2|Bacteria,1MU7P@1224|Proteobacteria,2VIK8@28216|Betaproteobacteria,2KKZ1@206350|Nitrosomonadales 206350|Nitrosomonadales BQ PFAM Histone deacetylase - - - - - - - - - - - - Hist_deacetyl k59_1702824_2 1458427.BAWN01000029_gene1692 1.32e-56 185.0 COG3672@1|root,COG3672@2|Bacteria,1RDQS@1224|Proteobacteria,2VR6A@28216|Betaproteobacteria,4ADUW@80864|Comamonadaceae 28216|Betaproteobacteria S Bacterial transglutaminase-like cysteine proteinase BTLCP - - - - - - - - - - - - Peptidase_C93 k59_742772_1 62928.azo1899 1e-09 60.1 COG1044@1|root,COG1044@2|Bacteria,1MUX6@1224|Proteobacteria,2VHJR@28216|Betaproteobacteria,2KVNR@206389|Rhodocyclales 206389|Rhodocyclales M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell lpxD - 2.3.1.191 ko:K02536 ko00540,ko01100,map00540,map01100 M00060 R04550 RC00039,RC00166 ko00000,ko00001,ko00002,ko01000,ko01005 - - - Hexapep,Hexapep_2,LpxD k59_742772_2 76114.ebA5997 5.79e-30 111.0 COG2825@1|root,COG2825@2|Bacteria,1RD8X@1224|Proteobacteria,2VRZI@28216|Betaproteobacteria,2KWH8@206389|Rhodocyclales 206389|Rhodocyclales M Belongs to the skp family - - - ko:K06142 - - - - ko00000 - - - OmpH k59_1759524_1 1229909.NSED_01420 7.97e-112 327.0 COG2520@1|root,arCOG00033@2157|Archaea,41S7P@651137|Thaumarchaeota 651137|Thaumarchaeota J Met-10+ like-protein - - 2.1.1.228 ko:K15429 - - R00597 RC00003,RC00334 ko00000,ko01000,ko03016 - - - Met_10 k59_347715_2 391625.PPSIR1_15565 2.47e-11 61.2 2A4R8@1|root,30TCM@2|Bacteria,1PD5K@1224|Proteobacteria,43DYZ@68525|delta/epsilon subdivisions,2WZ8R@28221|Deltaproteobacteria,2Z1KF@29|Myxococcales 28221|Deltaproteobacteria - - - - - - - - - - - - - - TerB k59_685927_1 111781.Lepto7376_1518 4.73e-23 99.8 COG2072@1|root,COG2072@2|Bacteria,1G32W@1117|Cyanobacteria 1117|Cyanobacteria P TIGRFAM flavin-dependent oxidoreductase, MSMEG_0569 family - - - ko:K07222 - - - - ko00000 - - - Pyr_redox_3 k59_685927_2 298655.KI912267_gene7609 1.76e-06 52.0 COG0491@1|root,COG0491@2|Bacteria,2GMDD@201174|Actinobacteria,4EUBY@85013|Frankiales 201174|Actinobacteria S Metallo-beta-lactamase superfamily - - - - - - - - - - - - Lactamase_B k59_1251189_1 1318628.MARLIPOL_05150 1.74e-11 67.8 2C3QV@1|root,2Z7YP@2|Bacteria,1MXAM@1224|Proteobacteria,1RNIA@1236|Gammaproteobacteria,4662K@72275|Alteromonadaceae 1236|Gammaproteobacteria S Alginate export - - - - - - - - - - - - Alginate_exp k59_1251189_2 1122134.KB893650_gene859 1.58e-46 165.0 COG2010@1|root,COG2010@2|Bacteria,1N3PN@1224|Proteobacteria,1RNS0@1236|Gammaproteobacteria,1XICD@135619|Oceanospirillales 135619|Oceanospirillales C Cytochrome D1 heme domain - - 1.7.2.1,1.7.99.1 ko:K15864 ko00910,ko01120,map00910,map01120 M00529 R00143,R00783,R00785 RC00086,RC02797 ko00000,ko00001,ko00002,ko01000 - - - Cytochrom_D1,Cytochrome_CBB3 k59_516278_2 1122137.AQXF01000004_gene1792 1.53e-138 394.0 COG0040@1|root,COG0040@2|Bacteria,1MUCY@1224|Proteobacteria,2TT0H@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity hisG GO:0000105,GO:0003674,GO:0003824,GO:0003879,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.4.2.17 ko:K00765 ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230 M00026 R01071 RC02819,RC03200 ko00000,ko00001,ko00002,ko01000 - - - HisG,HisG_C k59_856123_1 1163407.UU7_07228 2.12e-25 110.0 COG1643@1|root,COG1643@2|Bacteria,1MUEQ@1224|Proteobacteria,1RR1B@1236|Gammaproteobacteria,1X443@135614|Xanthomonadales 135614|Xanthomonadales L Helicase hrpB - 3.6.4.13 ko:K03579 - - - - ko00000,ko01000 - - - DEAD,HA2,Helicase_C,HrpB_C k59_1533787_2 768066.HELO_1418 2.64e-27 112.0 COG1012@1|root,COG1012@2|Bacteria,1MV2I@1224|Proteobacteria,1RPQW@1236|Gammaproteobacteria,1XHCT@135619|Oceanospirillales 135619|Oceanospirillales C Catalyzes the NAD-dependent reduction of succinylglutamate semialdehyde into succinylglutamate astD - 1.2.1.71 ko:K06447 ko00330,ko01100,map00330,map01100 - R05049 RC00080 ko00000,ko00001,ko01000 - - - Aldedh k59_347721_1 1545915.JROG01000004_gene2246 7.77e-80 254.0 COG4638@1|root,COG4638@2|Bacteria,1R4IX@1224|Proteobacteria,2U511@28211|Alphaproteobacteria,2K30Q@204457|Sphingomonadales 204457|Sphingomonadales P PFAM Rieske 2Fe-2S domain - - - - - - - - - - - - Rieske,Ring_hydroxyl_A k59_460114_1 743719.PaelaDRAFT_2949 1.51e-21 98.6 COG5285@1|root,COG5285@2|Bacteria,1V19S@1239|Firmicutes,4HEC1@91061|Bacilli,26RNZ@186822|Paenibacillaceae 91061|Bacilli Q Phytanoyl-CoA dioxygenase (PhyH) - - - - - - - - - - - - PhyH k59_460114_2 314254.OA2633_14636 2.81e-45 169.0 COG0477@1|root,COG2814@2|Bacteria,1RAYJ@1224|Proteobacteria,2U582@28211|Alphaproteobacteria,43XAC@69657|Hyphomonadaceae 28211|Alphaproteobacteria EGP COG0477 Permeases of the major facilitator superfamily - - - - - - - - - - - - MFS_1,MFS_3 k59_912298_1 945713.IALB_1680 4.26e-65 219.0 COG0480@1|root,COG0480@2|Bacteria 2|Bacteria J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome fusA2 GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006790,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0030312,GO:0044237,GO:0044464,GO:0071944 - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2 k59_403612_1 443144.GM21_3706 1.26e-53 191.0 COG3459@1|root,COG3459@2|Bacteria,1MVNX@1224|Proteobacteria,42PFN@68525|delta/epsilon subdivisions,2WJVD@28221|Deltaproteobacteria 28221|Deltaproteobacteria G glycosyltransferase 36 associated - - 2.4.1.20 ko:K00702,ko:K13688 ko00500,ko01100,map00500,map01100 - R00952 RC00049 ko00000,ko00001,ko01000,ko01003 - GH94,GT36,GT84 - Glyco_hydro_36,Glyco_transf_36,Glycoamylase k59_968404_1 1005048.CFU_2131 8.9e-10 62.0 COG0625@1|root,COG0625@2|Bacteria,1RAIN@1224|Proteobacteria,2VKU4@28216|Betaproteobacteria 28216|Betaproteobacteria O Belongs to the GST superfamily - - 2.5.1.18 ko:K00799 ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418 - R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905 RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944 ko00000,ko00001,ko01000,ko02000 1.A.12.2.2,1.A.12.3.2 - - GST_C,GST_C_3,GST_N k59_968404_2 272624.lpg1811 2.16e-16 78.2 COG0019@1|root,COG0527@1|root,COG0019@2|Bacteria,COG0527@2|Bacteria,1MUA6@1224|Proteobacteria,1SZXB@1236|Gammaproteobacteria,1JD6X@118969|Legionellales 118969|Legionellales E Belongs to the Orn Lys Arg decarboxylase class-II family lysAC - 2.7.2.4,4.1.1.20 ko:K12526 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01230 M00016,M00017,M00018,M00526,M00527 R00451,R00480 RC00002,RC00043,RC00299 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase,Orn_Arg_deC_N,Orn_DAP_Arg_deC k59_1533790_1 1122137.AQXF01000005_gene1368 2.76e-67 210.0 COG1309@1|root,COG1309@2|Bacteria,1R67Z@1224|Proteobacteria,2TUIS@28211|Alphaproteobacteria 28211|Alphaproteobacteria K tetR family' - - - - - - - - - - - - TetR_N k59_1533790_2 1114970.PSF113_5893 8.68e-54 178.0 COG0625@1|root,COG0625@2|Bacteria,1MWY4@1224|Proteobacteria,1RZJB@1236|Gammaproteobacteria,1YR03@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria O Belongs to the GST superfamily gstA - 2.5.1.18 ko:K00799 ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418 - R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905 RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944 ko00000,ko00001,ko01000,ko02000 1.A.12.2.2,1.A.12.3.2 - - GST_C,GST_C_2,GST_N k59_1081716_1 1144305.PMI02_03615 2.15e-20 90.1 COG2128@1|root,COG2128@2|Bacteria,1MVWP@1224|Proteobacteria,2TV9H@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Carboxymuconolactone decarboxylase family MA20_27265 - - - - - - - - - - - CMD k59_968410_1 1144275.COCOR_05212 9.78e-05 47.0 COG3210@1|root,COG3210@2|Bacteria,1P4K4@1224|Proteobacteria 1224|Proteobacteria U domain, Protein - - - - - - - - - - - - - k59_1137991_2 209285.XP_006693386.1 5.32e-06 52.8 COG0365@1|root,KOG1175@2759|Eukaryota,38DH9@33154|Opisthokonta,3NU7T@4751|Fungi,3QKBW@4890|Ascomycota,218CJ@147550|Sordariomycetes,3U8HW@5139|Sordariales,3HC80@35718|Chaetomiaceae 4751|Fungi I AMP-binding enzyme - - 6.2.1.16 ko:K01907 ko00280,ko00650,map00280,map00650 - R01357 RC00004,RC00014 ko00000,ko00001,ko01000,ko01004 - - - ACAS_N,AMP-binding k59_347740_1 279238.Saro_2968 1.34e-98 312.0 COG1251@1|root,COG1251@2|Bacteria,1MW58@1224|Proteobacteria,2TS8I@28211|Alphaproteobacteria,2K03B@204457|Sphingomonadales 204457|Sphingomonadales C Belongs to the nitrite and sulfite reductase 4Fe-4S domain family nirB - 1.7.1.15 ko:K00362 ko00910,ko01120,map00910,map01120 M00530 R00787 RC00176 ko00000,ko00001,ko00002,ko01000 - - - Fer2_BFD,NIR_SIR,NIR_SIR_ferr,Pyr_redox_2 k59_1477602_1 246196.MSMEI_2158 4.26e-06 52.0 COG1804@1|root,COG1804@2|Bacteria,2GIU7@201174|Actinobacteria,233VQ@1762|Mycobacteriaceae 201174|Actinobacteria C CoA-transferase family III - - - - - - - - - - - - CoA_transf_3 k59_347744_1 561229.Dd1591_3471 6.23e-119 357.0 COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,1RME8@1236|Gammaproteobacteria,2JDI4@204037|Dickeya 1236|Gammaproteobacteria O Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins ftsH GO:0000166,GO:0003674,GO:0003824,GO:0004175,GO:0004176,GO:0004222,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0008270,GO:0009056,GO:0009057,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030145,GO:0030163,GO:0030554,GO:0031224,GO:0031226,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043273,GO:0044238,GO:0044425,GO:0044459,GO:0044464,GO:0046872,GO:0046914,GO:0070011,GO:0071704,GO:0071944,GO:0097159,GO:0097367,GO:0098796,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575 - ko:K03798 - M00742 - - ko00000,ko00002,ko01000,ko01002,ko03110 - - - AAA,FtsH_ext,Peptidase_M41 k59_685955_1 1120919.AUBI01000026_gene3527 4.34e-06 49.3 COG2826@1|root,COG2826@2|Bacteria 2|Bacteria L transposase and inactivated derivatives, IS30 family - - - - - - - - - - - - HTH_38,rve k59_1646944_1 1380600.AUYN01000009_gene1294 4.65e-32 125.0 COG0457@1|root,COG0642@1|root,COG0457@2|Bacteria,COG2205@2|Bacteria,4NI29@976|Bacteroidetes,1HX1A@117743|Flavobacteriia 976|Bacteroidetes T Pfam Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - - - - - - - - - - - HATPase_c,HisKA,TPR_12,TPR_7,TPR_8 k59_291327_1 1193181.BN10_1010006 1.9e-85 270.0 COG0520@1|root,COG0520@2|Bacteria,2GP7W@201174|Actinobacteria,4FFVG@85021|Intrasporangiaceae 201174|Actinobacteria E Aminotransferase class-V - - - - - - - - - - - - Aminotran_5 k59_516307_2 189753.AXAS01000019_gene3473 1.59e-99 297.0 COG1540@1|root,COG1540@2|Bacteria,1MUYV@1224|Proteobacteria,2TQUC@28211|Alphaproteobacteria,3JXE7@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria S LamB/YcsF family - - - ko:K07160 - - - - ko00000 - - - LamB_YcsF k59_1533817_1 1144305.PMI02_00170 5.68e-126 373.0 COG0318@1|root,COG0318@2|Bacteria,1MUIC@1224|Proteobacteria,2TRRZ@28211|Alphaproteobacteria 28211|Alphaproteobacteria IQ COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II - - 6.2.1.3 ko:K01897 ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01004,ko04147 4.C.1.1 - - AMP-binding,AMP-binding_C k59_968436_1 1117647.M5M_01075 1.88e-55 194.0 COG0515@1|root,COG1262@1|root,COG0515@2|Bacteria,COG1262@2|Bacteria,1NQ5K@1224|Proteobacteria,1RWRX@1236|Gammaproteobacteria,1J6C2@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria KLT Sulfatase-modifying factor enzyme 1 - - 2.7.11.1 ko:K11912 ko02025,ko03070,map02025,map03070 - - - ko00000,ko00001,ko01000,ko01001,ko02044 - - - FGE-sulfatase k59_1251225_1 616991.JPOO01000001_gene4416 4.1e-128 376.0 COG2160@1|root,COG2160@2|Bacteria,4NHGG@976|Bacteroidetes,1HYCR@117743|Flavobacteriia 976|Bacteroidetes G Catalyzes the conversion of L-arabinose to L-ribulose araA - 5.3.1.4 ko:K01804 ko00040,ko01100,map00040,map01100 - R01761 RC00516 ko00000,ko00001,ko01000 - - - Arabinose_Iso_C,Arabinose_Isome k59_912331_1 589873.EP13_10740 3.66e-105 314.0 COG1215@1|root,COG1215@2|Bacteria,1MWH9@1224|Proteobacteria,1RPTN@1236|Gammaproteobacteria,4647V@72275|Alteromonadaceae 1236|Gammaproteobacteria M COG0463 Glycosyltransferases involved in cell wall biogenesis - - 2.4.1.266 ko:K13693 - - - - ko00000,ko01000,ko01003 - GT81 - - k59_1759565_1 1123296.JQKE01000038_gene318 1.32e-55 191.0 COG0187@1|root,COG0187@2|Bacteria,1MVH1@1224|Proteobacteria,2VHBQ@28216|Betaproteobacteria,2KPMW@206351|Neisseriales 206351|Neisseriales L Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule parE - - ko:K02622 - - - - ko00000,ko01000,ko02048,ko03032,ko03036 - - - DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim k59_1194603_1 313596.RB2501_06150 3.99e-108 315.0 COG2801@1|root,COG2801@2|Bacteria,4NI49@976|Bacteroidetes,1HWKR@117743|Flavobacteriia 976|Bacteroidetes L Pfam Integrase core domain - - - ko:K07497 - - - - ko00000 - - - HTH_21,HTH_Tnp_1,rve,rve_3 k59_1194603_2 1392489.JPOL01000002_gene2213 3.89e-35 122.0 COG2963@1|root,COG2963@2|Bacteria,4NVKT@976|Bacteroidetes,1I4CA@117743|Flavobacteriia 976|Bacteroidetes L Transposase - - - ko:K07483 - - - - ko00000 - - - HTH_Tnp_1 k59_685971_1 460265.Mnod_0806 1.3e-92 279.0 COG1024@1|root,COG1024@2|Bacteria,1MWZC@1224|Proteobacteria,2TRYS@28211|Alphaproteobacteria,1JT04@119045|Methylobacteriaceae 28211|Alphaproteobacteria I Belongs to the enoyl-CoA hydratase isomerase family - - 4.2.1.17 ko:K01692 ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212 M00032,M00087 R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093 RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 - - - ECH_1 k59_1364456_1 1120956.JHZK01000001_gene3262 7.22e-06 48.1 COG4786@1|root,COG4786@2|Bacteria,1PZ24@1224|Proteobacteria,2U06G@28211|Alphaproteobacteria,1JPAY@119043|Rhodobiaceae 28211|Alphaproteobacteria N Flagellar basal body rod FlgEFG protein C-terminal flgF - - ko:K02391,ko:K02392 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - Flg_bb_rod,Flg_bbr_C k59_1364456_3 443144.GM21_3900 4.25e-48 167.0 COG1639@1|root,COG1639@2|Bacteria,1QIEZ@1224|Proteobacteria,42PKV@68525|delta/epsilon subdivisions,2WKGI@28221|Deltaproteobacteria 28221|Deltaproteobacteria T HDOD domain - - - - - - - - - - - - HDOD k59_1646961_1 439496.RBY4I_1861 8.08e-156 461.0 COG0243@1|root,COG0243@2|Bacteria,1NS3T@1224|Proteobacteria,2TQYD@28211|Alphaproteobacteria 28211|Alphaproteobacteria C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family napA GO:0003674,GO:0003824,GO:0003954,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0048037,GO:0051536,GO:0051540,GO:0055114 - ko:K00372,ko:K02567 ko00910,ko01120,map00910,map01120 M00529,M00530,M00531 R00798,R01106 RC02812 ko00000,ko00001,ko00002,ko01000 - - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding k59_1251240_1 1122137.AQXF01000003_gene2400 1.7e-112 335.0 COG1344@1|root,COG1344@2|Bacteria,1MV1N@1224|Proteobacteria,2TUQQ@28211|Alphaproteobacteria 28211|Alphaproteobacteria N Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella flaA GO:0005575,GO:0005576,GO:0005623,GO:0009288,GO:0042995,GO:0043226,GO:0043228,GO:0044464 - ko:K02406 ko02020,ko02040,ko04621,ko04626,ko05132,ko05134,map02020,map02040,map04621,map04626,map05132,map05134 - - - ko00000,ko00001,ko02035 - - - Flagellin_C,Flagellin_N k59_1251240_2 1122137.AQXF01000001_gene2874 2.94e-10 58.2 COG0684@1|root,COG0684@2|Bacteria,1RH18@1224|Proteobacteria,2UCWD@28211|Alphaproteobacteria 28211|Alphaproteobacteria H Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions rraA - - ko:K02553 - - - - ko00000,ko03019 - - - RraA-like k59_1364460_1 1122137.AQXF01000001_gene3203 6.1e-50 172.0 COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2TR2W@28211|Alphaproteobacteria 28211|Alphaproteobacteria IQ COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II - - - - - - - - - - - - AMP-binding,AMP-binding_C k59_1364460_3 1122137.AQXF01000001_gene3201 5.99e-89 271.0 COG5345@1|root,COG5345@2|Bacteria,1MWVH@1224|Proteobacteria,2U0ZR@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Protein conserved in bacteria - - - - - - - - - - - - DUF2333 k59_1307834_1 1121926.AXWO01000014_gene1724 1.97e-31 126.0 COG2133@1|root,COG3291@1|root,COG3828@1|root,COG2133@2|Bacteria,COG3291@2|Bacteria,COG3828@2|Bacteria 2|Bacteria N Trehalose utilisation - - - ko:K09992 - - - - ko00000 - - - CBM_6,DUF1349,GSDH,PKD,ThuA k59_234048_1 1232410.KI421425_gene1552 4.01e-84 280.0 COG2885@1|root,COG2885@2|Bacteria,1QW22@1224|Proteobacteria,42TDV@68525|delta/epsilon subdivisions,2WP7K@28221|Deltaproteobacteria,43UHJ@69541|Desulfuromonadales 28221|Deltaproteobacteria M OmpA family - - - - - - - - - - - - OmpA k59_685989_1 938278.CAJO01000048_gene475 6.56e-09 62.8 COG1181@1|root,COG1181@2|Bacteria,1TRW2@1239|Firmicutes,24F2R@186801|Clostridia 186801|Clostridia M Belongs to the D-alanine--D-alanine ligase family - - 6.3.2.4 ko:K01921 ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502 - R01150 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - - Dala_Dala_lig_C k59_912349_2 1120953.AUBH01000005_gene2373 3.55e-52 181.0 28U7J@1|root,2ZGD7@2|Bacteria,1PA60@1224|Proteobacteria,1SUS6@1236|Gammaproteobacteria,46CC3@72275|Alteromonadaceae 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_1251268_1 316407.85674750 8.42e-120 360.0 COG1299@1|root,COG1445@1|root,COG1762@1|root,COG1299@2|Bacteria,COG1445@2|Bacteria,COG1762@2|Bacteria,1PF9N@1224|Proteobacteria,1RQCI@1236|Gammaproteobacteria,3XRKC@561|Escherichia 1236|Gammaproteobacteria G The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in mannosyl-D-glycerate transport. Also involved in thermoinduction of ompC hrsA GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008643,GO:0009401,GO:0015144,GO:0015711,GO:0015849,GO:0016020,GO:0016021,GO:0016740,GO:0016772,GO:0016773,GO:0022804,GO:0022857,GO:0031224,GO:0031226,GO:0034219,GO:0044425,GO:0044459,GO:0044464,GO:0046942,GO:0051179,GO:0051234,GO:0051476,GO:0055085,GO:0071702,GO:0071944,GO:0090563,GO:0090581,GO:1901264,GO:1901656 2.7.1.195,2.7.1.202 ko:K02768,ko:K11198,ko:K11199,ko:K11200 ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060 M00273,M00305 R03232,R11169 RC00017,RC03206 ko00000,ko00001,ko00002,ko01000,ko02000 4.A.2.1,4.A.2.1.3 - iECO26_1355.ECO26_0791 PTS_EIIA_2,PTS_EIIC,PTS_IIB k59_686002_1 1144310.PMI07_001716 1.61e-20 90.9 COG0697@1|root,COG0697@2|Bacteria,1MZQM@1224|Proteobacteria,2TUPG@28211|Alphaproteobacteria,4B737@82115|Rhizobiaceae 28211|Alphaproteobacteria EG Permeases of the drug metabolite transporter (DMT) superfamily - - - - - - - - - - - - EamA k59_177679_2 102129.Lepto7375DRAFT_7502 2.17e-20 85.5 COG2963@1|root,COG2963@2|Bacteria,1GAKB@1117|Cyanobacteria 1117|Cyanobacteria L IMG reference gene - - - - - - - - - - - - HTH_Tnp_1 k59_1194636_2 1029824.AFID01000002_gene1530 4.2e-31 119.0 COG1611@1|root,COG1611@2|Bacteria,2GKJH@201174|Actinobacteria,1W86V@1268|Micrococcaceae 201174|Actinobacteria S Belongs to the LOG family - - 3.2.2.10 ko:K06966 ko00230,ko00240,map00230,map00240 - R00182,R00510 RC00063,RC00318 ko00000,ko00001,ko01000 - - - Lysine_decarbox k59_912362_1 326427.Cagg_3435 1.35e-44 164.0 COG5297@1|root,COG5297@2|Bacteria,2G88J@200795|Chloroflexi,3771Q@32061|Chloroflexia 32061|Chloroflexia G type 3a cellulose-binding domain protein - - 3.2.1.4 ko:K01179 ko00500,ko01100,map00500,map01100 - R06200,R11307,R11308 - ko00000,ko00001,ko01000 - GH5,GH9 - CBM_2,CBM_3,Glyco_hydro_9 k59_1081781_1 641491.DND132_0515 4.99e-75 232.0 COG0005@1|root,COG0005@2|Bacteria,1MUWW@1224|Proteobacteria,42P5B@68525|delta/epsilon subdivisions,2WM02@28221|Deltaproteobacteria,2M7WB@213115|Desulfovibrionales 28221|Deltaproteobacteria F Purine nucleoside phosphorylase involved in purine salvage mtap - 2.4.2.28 ko:K00772 ko00270,ko01100,map00270,map01100 M00034 R01402 RC00063,RC02819 ko00000,ko00001,ko00002,ko01000 - - - PNP_UDP_1 k59_347790_1 1122185.N792_08240 4.46e-135 398.0 COG0364@1|root,COG0364@2|Bacteria,1MUN0@1224|Proteobacteria,1RQE4@1236|Gammaproteobacteria,1X59Z@135614|Xanthomonadales 135614|Xanthomonadales G Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone - - 1.1.1.363,1.1.1.49 ko:K00036 ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230 M00004,M00006,M00008 R00835,R02736,R10907 RC00001,RC00066 ko00000,ko00001,ko00002,ko01000,ko04147 - - - G6PD_C,G6PD_N k59_1420330_1 84531.JMTZ01000007_gene3449 1.65e-48 171.0 COG4102@1|root,COG4102@2|Bacteria,1MX4R@1224|Proteobacteria,1RR99@1236|Gammaproteobacteria,1X41W@135614|Xanthomonadales 135614|Xanthomonadales S Protein of unknown function (DUF1501) - - - - - - - - - - - - DUF1501 k59_1364490_1 1280949.HAD_00885 1.31e-10 67.0 COG2010@1|root,COG2010@2|Bacteria,1QVQX@1224|Proteobacteria,2TYUE@28211|Alphaproteobacteria 28211|Alphaproteobacteria C Protein of unknown function (DUF1587) - - - - - - - - - - - - PSCyt3,PSD2,PSD3,PSD4,PSD5 k59_1589812_1 1173028.ANKO01000064_gene3054 1.36e-92 287.0 COG0520@1|root,COG0520@2|Bacteria,1G0VG@1117|Cyanobacteria,1H95T@1150|Oscillatoriales 1117|Cyanobacteria E Selenocysteine lyase - - 5.1.1.17 ko:K04127 ko00311,ko01100,ko01130,map00311,map01100,map01130 M00673 R04147 RC00302 ko00000,ko00001,ko00002,ko01000 - - - Aminotran_5 k59_1589820_1 13690.CP98_02698 6.74e-50 175.0 COG2124@1|root,COG2124@2|Bacteria,1MY5H@1224|Proteobacteria,2TR6X@28211|Alphaproteobacteria 28211|Alphaproteobacteria Q Cytochrome P450 - - - - - - - - - - - - p450 k59_1138066_1 1415754.JQMK01000012_gene877 2.98e-53 184.0 COG2310@1|root,COG2310@2|Bacteria,1N7Q6@1224|Proteobacteria,1RYFB@1236|Gammaproteobacteria 1236|Gammaproteobacteria T stress, protein - - - - - - - - - - - - - k59_637614_2 7029.ACYPI007254-PA 4.27e-26 103.0 COG0251@1|root,KOG2317@2759|Eukaryota,3A5RT@33154|Opisthokonta,3BQRB@33208|Metazoa,3D86F@33213|Bilateria,420UY@6656|Arthropoda,3SN3V@50557|Insecta,3EBHF@33342|Paraneoptera 33208|Metazoa J Endoribonuclease L-PSP HRSP12 GO:0001505,GO:0001655,GO:0001822,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0005488,GO:0005504,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005739,GO:0005759,GO:0005777,GO:0005829,GO:0006082,GO:0006139,GO:0006417,GO:0006457,GO:0006520,GO:0006544,GO:0006566,GO:0006567,GO:0006725,GO:0006807,GO:0007049,GO:0007275,GO:0007399,GO:0007417,GO:0007420,GO:0008150,GO:0008152,GO:0008285,GO:0008289,GO:0009056,GO:0009063,GO:0009066,GO:0009068,GO:0009069,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010033,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0016054,GO:0016070,GO:0016787,GO:0016788,GO:0016892,GO:0016894,GO:0017144,GO:0017148,GO:0019222,GO:0019239,GO:0019518,GO:0019752,GO:0022402,GO:0030323,GO:0030324,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031406,GO:0031974,GO:0032268,GO:0032269,GO:0032501,GO:0032502,GO:0033293,GO:0033993,GO:0034248,GO:0034249,GO:0034641,GO:0035295,GO:0036041,GO:0036094,GO:0042127,GO:0042133,GO:0042221,GO:0042579,GO:0042737,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043177,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046395,GO:0046483,GO:0046872,GO:0046914,GO:0046983,GO:0048513,GO:0048519,GO:0048523,GO:0048731,GO:0048856,GO:0050678,GO:0050680,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0060322,GO:0060541,GO:0065007,GO:0065008,GO:0070013,GO:0070314,GO:0071704,GO:0072001,GO:0080090,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606,GO:1902074,GO:1904012,GO:1904013,GO:2000112,GO:2000113 3.5.99.10 ko:K09022 - - R11098,R11099 RC03275,RC03354 ko00000,ko01000 - - - Ribonuc_L-PSP k59_356121_1 1229909.NSED_09225 2.4e-64 207.0 COG0430@1|root,arCOG04125@2157|Archaea,41T1K@651137|Thaumarchaeota 651137|Thaumarchaeota J Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps (A) adenylation of the enzyme by ATP rtcA - 6.5.1.4 ko:K01974 - - - - ko00000,ko01000 - - - RTC k59_299518_1 754331.AEME01000001_gene1430 1.99e-131 377.0 COG1176@1|root,COG1176@2|Bacteria,1MVGM@1224|Proteobacteria,1RNNZ@1236|Gammaproteobacteria,3XPCI@561|Escherichia 1236|Gammaproteobacteria P Binding-protein-dependent transport system inner membrane component potB GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008324,GO:0008519,GO:0015075,GO:0015101,GO:0015203,GO:0015399,GO:0015405,GO:0015417,GO:0015595,GO:0015606,GO:0015695,GO:0015696,GO:0015846,GO:0015847,GO:0015848,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022857,GO:0031224,GO:0031226,GO:0032991,GO:0034220,GO:0042623,GO:0042626,GO:0043190,GO:0043492,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0072488,GO:0098533,GO:0098655,GO:0098796,GO:0098797,GO:1902047,GO:1902494,GO:1902495,GO:1903711,GO:1904949,GO:1990351 - ko:K11071 ko02010,map02010 M00299 - - ko00000,ko00001,ko00002,ko02000 3.A.1.11.1 - iE2348C_1286.E2348C_1266,iECUMN_1333.ECUMN_1368,iSBO_1134.SBO_1916 BPD_transp_1 k59_16526_1 83406.HDN1F_05170 4.51e-56 183.0 COG0708@1|root,COG0708@2|Bacteria,1MVII@1224|Proteobacteria,1RN4H@1236|Gammaproteobacteria,1J51Q@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria L exodeoxyribonuclease III crc - 3.1.11.2 ko:K01142 ko03410,map03410 - - - ko00000,ko00001,ko01000,ko03400 - - - Exo_endo_phos k59_16526_2 1265503.KB905161_gene3327 2.38e-15 75.5 COG2270@1|root,COG2270@2|Bacteria,1QUVA@1224|Proteobacteria,1T226@1236|Gammaproteobacteria,2Q6F8@267889|Colwelliaceae 1236|Gammaproteobacteria S Acetyl-coenzyme A transporter 1 Z012_03780 - - ko:K08218 ko01501,map01501 M00628 - - ko00000,ko00001,ko00002,ko02000 2.A.1.25 - - MFS_1 k59_1598094_1 649831.L083_0358 2.06e-117 357.0 2C9AC@1|root,2Z7TR@2|Bacteria,2I07F@201174|Actinobacteria,4DFXX@85008|Micromonosporales 201174|Actinobacteria S Phage portal protein, SPP1 Gp6-like - - - - - - - - - - - - Phage_prot_Gp6 k59_524113_1 880070.Cycma_5075 2.54e-09 62.8 COG4146@1|root,COG4146@2|Bacteria,4NE9S@976|Bacteroidetes,47KIN@768503|Cytophagia 976|Bacteroidetes S Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family - - - ko:K03307 - - - - ko00000 2.A.21 - - SSF k59_524113_2 306264.CUP0885 6.71e-21 89.0 COG0231@1|root,COG0231@2|Bacteria,1MW2J@1224|Proteobacteria,42N6H@68525|delta/epsilon subdivisions,2YM7S@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria J Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase efp - - ko:K02356 - - - - ko00000,ko03012 - - - EFP,EFP_N,Elong-fact-P_C k59_242093_1 1183438.GKIL_2649 2.36e-34 129.0 COG3503@1|root,COG3503@2|Bacteria 2|Bacteria J Membrane - - - - - - - - - - - - DUF1624,DUF418 k59_242093_2 1122137.AQXF01000002_gene377 3.76e-56 179.0 COG0457@1|root,COG0457@2|Bacteria,1N9D5@1224|Proteobacteria,2UIQ4@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Tetratricopeptide repeat - - - - - - - - - - - - - k59_1428299_1 1096930.L284_01030 1.31e-20 84.7 COG5570@1|root,COG5570@2|Bacteria,1NGRE@1224|Proteobacteria,2UJAX@28211|Alphaproteobacteria,2K7RY@204457|Sphingomonadales 204457|Sphingomonadales S Protein of unknown function (DUF465) - - - - - - - - - - - - DUF465 k59_1428299_2 1096930.L284_01025 1.2e-52 182.0 COG3605@1|root,COG3605@2|Bacteria,1QTTV@1224|Proteobacteria,2TR3Z@28211|Alphaproteobacteria,2K17Q@204457|Sphingomonadales 204457|Sphingomonadales T Belongs to the PEP-utilizing enzyme family ptsP - 2.7.3.9 ko:K08484 ko02060,map02060 - - - ko00000,ko00001,ko01000,ko02000 - - - GAF_2,PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C k59_750518_1 338966.Ppro_0536 2.17e-86 273.0 COG2805@1|root,COG2805@2|Bacteria,1MU3J@1224|Proteobacteria,42M7F@68525|delta/epsilon subdivisions,2WIMF@28221|Deltaproteobacteria,43TTT@69541|Desulfuromonadales 28221|Deltaproteobacteria NU Type II/IV secretion system protein pilT-3 - - ko:K02669 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE k59_1034183_1 436308.Nmar_1633 1.1e-112 330.0 COG0388@1|root,arCOG00062@2157|Archaea,41SF8@651137|Thaumarchaeota 651137|Thaumarchaeota S Carbon-nitrogen hydrolase - - - ko:K11206 - - - - ko00000,ko01000 - - - CN_hydrolase k59_920044_1 565045.NOR51B_181 7.88e-100 300.0 COG2204@1|root,COG2204@2|Bacteria,1MWW5@1224|Proteobacteria,1RND4@1236|Gammaproteobacteria 1236|Gammaproteobacteria K transcriptional activator pspF - - ko:K03974 - - - - ko00000,ko03000 - - - HTH_8,Sigma54_activat k59_1145862_1 1320556.AVBP01000011_gene3342 3.86e-06 50.4 COG2132@1|root,COG2132@2|Bacteria,1MU0J@1224|Proteobacteria,2TURI@28211|Alphaproteobacteria,43P45@69277|Phyllobacteriaceae 28211|Alphaproteobacteria Q Multicopper oxidase - - 1.3.3.5 ko:K04753,ko:K08100 ko00860,ko01110,map00860,map01110 - R02394 RC01983 ko00000,ko00001,ko01000 - - - Cu-oxidase,Cu-oxidase_2,Cu-oxidase_3 k59_1145862_2 436308.Nmar_0208 4.42e-72 223.0 COG0681@1|root,arCOG01739@2157|Archaea,41SQ2@651137|Thaumarchaeota 651137|Thaumarchaeota U Signal peptidase - - 3.4.21.89 ko:K13280 ko03060,map03060 - - - ko00000,ko00001,ko01000,ko01002 - - - Peptidase_S24 k59_581196_1 983544.Lacal_0743 9.38e-95 302.0 COG1629@1|root,COG4773@1|root,COG1629@2|Bacteria,COG4773@2|Bacteria,4PKRK@976|Bacteroidetes,1IJDQ@117743|Flavobacteriia 976|Bacteroidetes P receptor - - - - - - - - - - - - CarbopepD_reg_2,CarboxypepD_reg,Plug,TonB_dep_Rec k59_864603_1 702113.PP1Y_AT10035 5.81e-19 81.3 COG1595@1|root,COG1595@2|Bacteria,1MZMC@1224|Proteobacteria,2UAM7@28211|Alphaproteobacteria,2KD1H@204457|Sphingomonadales 204457|Sphingomonadales K ECF sigma factor - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 k59_864603_2 702113.PP1Y_AT10029 2.54e-20 91.3 COG5662@1|root,COG5662@2|Bacteria,1N1PB@1224|Proteobacteria,2VGMS@28211|Alphaproteobacteria,2KE4R@204457|Sphingomonadales 204457|Sphingomonadales K AntiSigma factor - - - - - - - - - - - - - k59_1145864_1 1088721.NSU_1557 6.93e-48 156.0 COG0222@1|root,COG0222@2|Bacteria,1RGU4@1224|Proteobacteria,2U9FX@28211|Alphaproteobacteria,2K4H8@204457|Sphingomonadales 204457|Sphingomonadales J Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation rplL - - ko:K02935 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L12,Ribosomal_L12_N k59_1145864_2 983920.Y88_2146 1.91e-15 73.2 COG0244@1|root,COG0244@2|Bacteria,1RAN5@1224|Proteobacteria,2U592@28211|Alphaproteobacteria,2K3XB@204457|Sphingomonadales 204457|Sphingomonadales J Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors rplJ - - ko:K02864 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L10 k59_694192_2 491952.Mar181_2668 4.82e-46 156.0 COG4149@1|root,COG4149@2|Bacteria,1MUXR@1224|Proteobacteria,1RRDV@1236|Gammaproteobacteria,1XJ75@135619|Oceanospirillales 135619|Oceanospirillales P (ABC) transporter modB - - ko:K02018 ko02010,map02010 M00189 - - ko00000,ko00001,ko00002,ko02000 3.A.1.8 - - BPD_transp_1 k59_1428317_1 986075.CathTA2_0642 3.19e-35 135.0 COG1012@1|root,COG1012@2|Bacteria,1TP4S@1239|Firmicutes,4H9MF@91061|Bacilli 91061|Bacilli C Belongs to the aldehyde dehydrogenase family aldHT_1 - - ko:K22187 ko00040,map00040 - R11768 RC00080 ko00000,ko00001,ko01000 - - - Aldedh k59_16546_1 1229909.NSED_01935 5.07e-84 250.0 COG1841@1|root,arCOG04086@2157|Archaea,41SMX@651137|Thaumarchaeota 651137|Thaumarchaeota J ribosomal protein - - - ko:K02907 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L30 k59_1767610_2 436308.Nmar_1728 1.41e-138 393.0 COG0638@1|root,arCOG00970@2157|Archaea,41T1N@651137|Thaumarchaeota 651137|Thaumarchaeota O Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation - - 3.4.25.1 ko:K03433 ko03050,map03050 M00342,M00343 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03051 - - - Proteasome k59_1316003_1 1122225.AULQ01000010_gene178 3.77e-94 298.0 COG0249@1|root,COG0249@2|Bacteria,4NEGB@976|Bacteroidetes,1HX43@117743|Flavobacteriia 976|Bacteroidetes L that it carries out the mismatch recognition step. This protein has a weak ATPase activity mutS GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - ko:K03555 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V k59_1711137_1 62928.azo3873 2.34e-12 67.4 COG2303@1|root,COG2303@2|Bacteria,1MU3F@1224|Proteobacteria,2VIBA@28216|Betaproteobacteria,2KXW8@206389|Rhodocyclales 206389|Rhodocyclales E GMC oxidoreductase - - - - - - - - - - - - GMC_oxred_C,GMC_oxred_N k59_1711137_2 1312959.KI914670_gene1627 1.35e-12 70.5 2BXMA@1|root,2ZBQ1@2|Bacteria,2IK3R@201174|Actinobacteria,1WB3A@1268|Micrococcaceae 201174|Actinobacteria S (twin-arginine translocation) pathway signal - - - - - - - - - - - - - k59_920051_1 1122137.AQXF01000002_gene320 3.61e-51 167.0 COG0194@1|root,COG0194@2|Bacteria,1MW92@1224|Proteobacteria,2TSCQ@28211|Alphaproteobacteria 28211|Alphaproteobacteria F Essential for recycling GMP and indirectly, cGMP gmk GO:0003674,GO:0003824,GO:0004385,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009126,GO:0009132,GO:0009135,GO:0009150,GO:0009161,GO:0009165,GO:0009167,GO:0009179,GO:0009185,GO:0009259,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0042278,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046037,GO:0046128,GO:0046483,GO:0046710,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901576,GO:1901657 2.7.4.8 ko:K00942 ko00230,ko01100,map00230,map01100 M00050 R00332,R02090 RC00002 ko00000,ko00001,ko00002,ko01000 - - - Guanylate_kin k59_920051_2 1122137.AQXF01000002_gene319 1.52e-31 118.0 COG0030@1|root,COG0030@2|Bacteria,1MVNU@1224|Proteobacteria,2TRD9@28211|Alphaproteobacteria 28211|Alphaproteobacteria J Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits ksgA GO:0000154,GO:0000179,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016433,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360 2.1.1.182 ko:K02528 - - R10716 RC00003,RC03257 ko00000,ko01000,ko03009 - - - RrnaAD k59_1145877_1 561231.Pecwa_3100 2.06e-68 230.0 COG0567@1|root,COG0567@2|Bacteria,1MVBF@1224|Proteobacteria,1RN8K@1236|Gammaproteobacteria,1MQAN@122277|Pectobacterium 1236|Gammaproteobacteria C 2-oxoglutarate dehydrogenase sucA GO:0000287,GO:0003674,GO:0003824,GO:0004591,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016491,GO:0016624,GO:0016903,GO:0016999,GO:0017144,GO:0019752,GO:0019842,GO:0030976,GO:0032991,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045239,GO:0045240,GO:0045252,GO:0045333,GO:0046872,GO:0048037,GO:0050662,GO:0055114,GO:0071704,GO:0072350,GO:0097159,GO:1901363,GO:1901681,GO:1902494,GO:1990204,GO:1990234 1.2.4.2 ko:K00164 ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200 M00009,M00011,M00032 R00621,R01933,R01940,R03316,R08549 RC00004,RC00027,RC00627,RC02743,RC02833,RC02883 br01601,ko00000,ko00001,ko00002,ko01000 - - iSSON_1240.SSON_0677,iYL1228.KPN_00732 2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr k59_1598122_1 405948.SACE_5377 2.45e-14 75.1 COG2141@1|root,COG2141@2|Bacteria,2H0K9@201174|Actinobacteria,4E22U@85010|Pseudonocardiales 201174|Actinobacteria C Luciferase-like monooxygenase - - 1.14.14.5 ko:K04091 ko00920,map00920 - R07210,R10206 RC01779,RC02556 ko00000,ko00001,ko01000 - - - Bac_luciferase k59_1202901_2 488538.SAR116_2361 1.76e-05 50.1 COG4785@1|root,COG4785@2|Bacteria,1R0JJ@1224|Proteobacteria,2TYRH@28211|Alphaproteobacteria,4BTFI@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria S Tetratricopeptide repeat - - - - - - - - - - - - TPR_2 k59_1541916_1 436308.Nmar_0059 4.73e-75 231.0 COG2875@1|root,arCOG00645@2157|Archaea,41SE7@651137|Thaumarchaeota 651137|Thaumarchaeota H Tetrapyrrole (Corrin/Porphyrin) Methylases - - 2.1.1.133,2.1.1.271 ko:K05936 ko00860,ko01100,map00860,map01100 - R05181,R05810 RC00003,RC01294,RC02049 ko00000,ko00001,ko01000 - - - TP_methylase k59_1541916_2 1123502.AQXD01000005_gene1735 2.81e-09 62.8 COG0796@1|root,COG0796@2|Bacteria,1NAI2@1224|Proteobacteria,1RPU9@1236|Gammaproteobacteria,1X6TA@135614|Xanthomonadales 135614|Xanthomonadales M Asp/Glu/Hydantoin racemase - - - - - - - - - - - - Asp_Glu_race k59_468031_1 1442599.JAAN01000043_gene419 3.43e-18 87.8 COG2503@1|root,COG2503@2|Bacteria,1RB4N@1224|Proteobacteria,1RY2I@1236|Gammaproteobacteria,1XC38@135614|Xanthomonadales 135614|Xanthomonadales S HAD superfamily, subfamily IIIB (Acid phosphatase) - - - - - - - - - - - - Acid_phosphat_B k59_1428331_1 247634.GPB2148_2692 1.73e-17 88.2 COG2304@1|root,COG2373@1|root,COG2931@1|root,COG3291@1|root,COG2304@2|Bacteria,COG2373@2|Bacteria,COG2931@2|Bacteria,COG3291@2|Bacteria,1MU7T@1224|Proteobacteria,1S67V@1236|Gammaproteobacteria,1J70M@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria Q Calx-beta domain - - - - - - - - - - - - Calx-beta k59_1655291_1 1131266.ARWQ01000010_gene30 2.15e-151 433.0 COG1180@1|root,arCOG00946@2157|Archaea,41SBZ@651137|Thaumarchaeota 651137|Thaumarchaeota C Radical SAM - - 1.97.1.4 ko:K04069 - - R04710 - ko00000,ko01000 - - - Radical_SAM k59_864621_1 1348657.M622_04405 1.59e-90 280.0 COG1060@1|root,COG1060@2|Bacteria,1MX50@1224|Proteobacteria 1224|Proteobacteria H Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2) mqnC - 1.21.98.1,2.5.1.77 ko:K11779,ko:K11784 ko00130,ko00680,ko01110,ko01120,map00130,map00680,map01110,map01120 M00378 R08588,R09396 RC01381,RC02329,RC03002,RC03007 ko00000,ko00001,ko00002,ko01000 - - - Radical_SAM k59_1145888_1 588932.JHOF01000026_gene394 1.2e-66 208.0 COG0662@1|root,COG1396@1|root,COG0662@2|Bacteria,COG1396@2|Bacteria,1RCYA@1224|Proteobacteria,2TU8R@28211|Alphaproteobacteria 28211|Alphaproteobacteria K Transcriptional regulator MA20_09770 - - - - - - - - - - - Cupin_2,HTH_3,HTH_31 k59_637677_1 1122137.AQXF01000002_gene409 5.1e-50 176.0 COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TQQ9@28211|Alphaproteobacteria 28211|Alphaproteobacteria T Histidine kinase cckA - 2.7.13.3 ko:K13587 ko02020,ko04112,map02020,map04112 M00512 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA,PAS,PAS_4,PAS_8,PAS_9,Response_reg k59_637677_2 1122137.AQXF01000002_gene408 2.22e-49 166.0 COG0468@1|root,COG0468@2|Bacteria,1MU3C@1224|Proteobacteria,2TRPR@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage recA GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716,GO:0071496 - ko:K03553 ko03440,map03440 M00729 - - ko00000,ko00001,ko00002,ko03400 - - - RecA k59_864627_1 1168065.DOK_03388 1.65e-08 54.7 2E4CH@1|root,32Z7Y@2|Bacteria,1NBRN@1224|Proteobacteria,1SCB9@1236|Gammaproteobacteria,1J7D3@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S pilus assembly protein, PilZ - - - - - - - - - - - - PilZ k59_750551_1 593907.Celgi_2187 0.00032 47.0 COG1045@1|root,COG1045@2|Bacteria,2IHW5@201174|Actinobacteria,4F0NW@85016|Cellulomonadaceae 201174|Actinobacteria E Bacterial transferase hexapeptide (six repeats) cysE GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008374,GO:0008652,GO:0009001,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016407,GO:0016412,GO:0016413,GO:0016740,GO:0016746,GO:0016747,GO:0019344,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.3.1.30 ko:K00640 ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111 M00021 R00586 RC00004,RC00041 ko00000,ko00001,ko00002,ko01000 - - - Hexapep,SATase_N k59_129667_1 89462.XP_006043373.1 1.57e-16 79.0 COG0278@1|root,KOG0911@2759|Eukaryota,38BF9@33154|Opisthokonta,3BC2Q@33208|Metazoa,3CSGU@33213|Bilateria,488H7@7711|Chordata,496IN@7742|Vertebrata,3J33V@40674|Mammalia,4J1EM@91561|Cetartiodactyla 33208|Metazoa O Glutaredoxin GLRX3 GO:0002026,GO:0003674,GO:0005080,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0006790,GO:0006807,GO:0008016,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0010611,GO:0010614,GO:0014741,GO:0014743,GO:0016043,GO:0016226,GO:0019538,GO:0019899,GO:0019900,GO:0019901,GO:0020027,GO:0022607,GO:0030016,GO:0030017,GO:0030018,GO:0030425,GO:0031163,GO:0031674,GO:0036477,GO:0042592,GO:0042802,GO:0042995,GO:0043005,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043292,GO:0043502,GO:0044057,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044422,GO:0044424,GO:0044444,GO:0044449,GO:0044463,GO:0044464,GO:0044571,GO:0048519,GO:0048583,GO:0048878,GO:0050789,GO:0050801,GO:0051186,GO:0051239,GO:0051241,GO:0051604,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0065007,GO:0065008,GO:0071704,GO:0071840,GO:0090257,GO:0097428,GO:0097447,GO:0097458,GO:0098771,GO:0099080,GO:0099081,GO:0099512,GO:0120025,GO:0120038,GO:1901564,GO:1903522 - ko:K15216 - - - - ko00000,ko03021 - - - Glutaredoxin,Thioredoxin k59_129667_2 1121921.KB898710_gene588 2.37e-42 145.0 COG0847@1|root,COG0847@2|Bacteria,1MUPK@1224|Proteobacteria,1RMMH@1236|Gammaproteobacteria,2PN7B@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria L EXOIII rnt GO:0000287,GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004540,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008408,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0031123,GO:0034470,GO:0034641,GO:0034660,GO:0042780,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0043628,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0140098,GO:1901360 - ko:K03683 - - - - ko00000,ko01000,ko03016 - - - RNase_T k59_1372786_1 1122194.AUHU01000005_gene911 4.31e-89 275.0 COG0516@1|root,COG0517@1|root,COG0516@2|Bacteria,COG0517@2|Bacteria,1MUJM@1224|Proteobacteria,1RMT8@1236|Gammaproteobacteria,464HQ@72275|Alteromonadaceae 1236|Gammaproteobacteria F Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth guaB GO:0003674,GO:0003824,GO:0003938,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006183,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009314,GO:0009411,GO:0009416,GO:0009628,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046039,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0050896,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659 1.1.1.205 ko:K00088 ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 M00050 R01130,R08240 RC00143,RC02207 ko00000,ko00001,ko00002,ko01000,ko04147 - - iAPECO1_1312.APECO1_4018,iECABU_c1320.ECABU_c28100,iECP_1309.ECP_2510,iECSF_1327.ECSF_2349,iUTI89_1310.UTI89_C2826,ic_1306.c3027 CBS,IMPDH,NMO k59_1316041_1 1517416.IDAT_09280 1.32e-67 225.0 COG0021@1|root,COG0021@2|Bacteria,1MUEY@1224|Proteobacteria,1RMWP@1236|Gammaproteobacteria,2QFPW@267893|Idiomarinaceae 1236|Gammaproteobacteria H Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate tktA GO:0000302,GO:0003674,GO:0003824,GO:0004802,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006098,GO:0006139,GO:0006355,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009052,GO:0009117,GO:0009635,GO:0009636,GO:0009719,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010033,GO:0010035,GO:0010243,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016740,GO:0016744,GO:0019219,GO:0019222,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0019842,GO:0030145,GO:0030976,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032991,GO:0033554,GO:0034599,GO:0034614,GO:0034641,GO:0035690,GO:0036094,GO:0036245,GO:0042221,GO:0042493,GO:0042542,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045893,GO:0045935,GO:0046483,GO:0046496,GO:0046677,GO:0046872,GO:0046914,GO:0048037,GO:0048518,GO:0048522,GO:0050662,GO:0050789,GO:0050794,GO:0050896,GO:0051156,GO:0051171,GO:0051173,GO:0051186,GO:0051252,GO:0051254,GO:0051716,GO:0055086,GO:0060255,GO:0065007,GO:0070301,GO:0070887,GO:0071236,GO:0071310,GO:0071417,GO:0071495,GO:0071704,GO:0072524,GO:0072747,GO:0072756,GO:0080090,GO:0097159,GO:0097237,GO:1901135,GO:1901322,GO:1901360,GO:1901363,GO:1901562,GO:1901564,GO:1901654,GO:1901655,GO:1901681,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141 2.2.1.1 ko:K00615 ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230 M00004,M00007,M00165,M00167 R01067,R01641,R01830,R06590 RC00032,RC00226,RC00571,RC01560 ko00000,ko00001,ko00002,ko01000 - - iECABU_c1320.ECABU_c27750,iLF82_1304.LF82_2271,iNRG857_1313.NRG857_12300,iSDY_1059.SDY_3141,iYL1228.KPN_01127,iYL1228.KPN_02799,ic_1306.c2990 Transket_pyr,Transketolase_C,Transketolase_N k59_1145910_1 1122137.AQXF01000001_gene3210 4.33e-81 253.0 COG1004@1|root,COG1004@2|Bacteria,1MW5U@1224|Proteobacteria,2TREV@28211|Alphaproteobacteria 28211|Alphaproteobacteria M Belongs to the UDP-glucose GDP-mannose dehydrogenase family rkpK GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 1.1.1.22 ko:K00012 ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100 M00014,M00129,M00361,M00362 R00286 RC00291 ko00000,ko00001,ko00002,ko01000 - - - UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N k59_1145911_1 1219375.CM002139_gene3459 1.16e-17 83.6 COG0583@1|root,COG0583@2|Bacteria,1MWVU@1224|Proteobacteria,1RPT8@1236|Gammaproteobacteria,1X3T2@135614|Xanthomonadales 135614|Xanthomonadales K Transcriptional regulator - - - - - - - - - - - - HTH_1,LysR_substrate k59_1428359_1 935557.ATYB01000008_gene5848 3.42e-21 100.0 COG0457@1|root,COG3710@1|root,COG5616@1|root,COG0457@2|Bacteria,COG3710@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2TRUI@28211|Alphaproteobacteria,4B9US@82115|Rhizobiaceae 28211|Alphaproteobacteria T Adenylate cyclase - - - - - - - - - - - - Guanylate_cyc,Trans_reg_C k59_1089621_1 702113.PP1Y_AT977 1.12e-20 92.0 COG3182@1|root,COG3182@2|Bacteria,1MXGY@1224|Proteobacteria,2TV6J@28211|Alphaproteobacteria 28211|Alphaproteobacteria S PepSY-associated TM helix MA20_29520 - - - - - - - - - - - PepSY_TM k59_1316062_2 436308.Nmar_1724 1.78e-183 516.0 COG0006@1|root,arCOG01000@2157|Archaea,41T14@651137|Thaumarchaeota 651137|Thaumarchaeota E Belongs to the peptidase M24B family - - 3.4.11.9,3.4.13.9 ko:K01262,ko:K01271 - - - - ko00000,ko01000,ko01002 - - - Creatinase_N,Peptidase_M24 k59_1541966_1 1232453.BAIF02000004_gene1541 1.12e-12 72.0 COG0524@1|root,COG0524@2|Bacteria,1UFS8@1239|Firmicutes,24IGK@186801|Clostridia 186801|Clostridia G pfkB family carbohydrate kinase - - - - - - - - - - - - PfkB k59_1202941_2 1123504.JQKD01000079_gene5790 2.77e-117 345.0 COG0329@1|root,COG0329@2|Bacteria,1MWMN@1224|Proteobacteria,2W0EN@28216|Betaproteobacteria 28216|Betaproteobacteria EM Dihydrodipicolinate synthetase family - - - - - - - - - - - - DHDPS k59_356174_1 1144305.PMI02_00893 1.18e-72 226.0 COG0346@1|root,COG0346@2|Bacteria,1RDMC@1224|Proteobacteria,2U54J@28211|Alphaproteobacteria,2K37X@204457|Sphingomonadales 204457|Sphingomonadales E lactoylglutathione lyase activity - - - - - - - - - - - - - k59_1767666_1 1191523.MROS_1756 7.98e-11 68.9 COG1404@1|root,COG1404@2|Bacteria 2|Bacteria O Belongs to the peptidase S8 family - - - - - - - - - - - - - k59_864673_1 1163408.UU9_06299 1.12e-65 214.0 COG0303@1|root,COG0303@2|Bacteria,1MVD5@1224|Proteobacteria,1RMQU@1236|Gammaproteobacteria,1X5HG@135614|Xanthomonadales 135614|Xanthomonadales H molybdopterin biosynthesis moeA1 - 2.10.1.1 ko:K03750 ko00790,ko01100,map00790,map01100 - R09735 RC03462 ko00000,ko00001,ko01000 - - - MoCF_biosynth,MoeA_C,MoeA_N k59_73764_1 59538.XP_005979108.1 5.61e-132 392.0 COG0028@1|root,KOG1185@2759|Eukaryota,38EFU@33154|Opisthokonta,3BGF6@33208|Metazoa,3CUC0@33213|Bilateria,4815T@7711|Chordata,494NR@7742|Vertebrata,3J1W3@40674|Mammalia 2759|Eukaryota EH fatty acid alpha-oxidation - - - - - - - - - - - - TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N k59_581273_1 859657.RPSI07_1263 1.25e-39 145.0 COG0635@1|root,COG0635@2|Bacteria,1MU76@1224|Proteobacteria,2VHBB@28216|Betaproteobacteria,1K01J@119060|Burkholderiaceae 28216|Betaproteobacteria H Involved in the biosynthesis of porphyrin-containing compound hemN2 - - - - - - - - - - - HemN_C,Radical_SAM k59_1202952_1 1123270.ATUR01000002_gene2343 5.05e-86 281.0 COG0823@1|root,COG1228@1|root,COG0823@2|Bacteria,COG1228@2|Bacteria,1MX3A@1224|Proteobacteria,2TUU6@28211|Alphaproteobacteria,2K0I3@204457|Sphingomonadales 204457|Sphingomonadales QU Periplasmic component of the Tol biopolymer transport system - - - - - - - - - - - - Amidohydro_1,PD40 k59_1372837_1 631362.Thi970DRAFT_04589 2.3e-28 108.0 COG0558@1|root,COG0558@2|Bacteria,1RCZ7@1224|Proteobacteria,1S465@1236|Gammaproteobacteria,1WXKW@135613|Chromatiales 135613|Chromatiales I Belongs to the CDP-alcohol phosphatidyltransferase class-I family - - 2.7.8.41,2.7.8.5 ko:K00995,ko:K08744 ko00564,ko01100,map00564,map01100 - R01801,R02030 RC00002,RC00017,RC02795 ko00000,ko00001,ko01000 - - - CDP-OH_P_transf k59_411634_1 1313172.YM304_16960 1.03e-49 175.0 COG3119@1|root,COG3119@2|Bacteria,2GJ8H@201174|Actinobacteria 201174|Actinobacteria P Pfam Sulfatase - - - - - - - - - - - - DUF4976,Sulfatase k59_129702_1 436308.Nmar_0973 1.08e-75 239.0 arCOG08728@1|root,arCOG08728@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_1767692_1 272623.L0123 1.35e-07 55.8 COG0745@1|root,COG0745@2|Bacteria,1TPWS@1239|Firmicutes,4H9KP@91061|Bacilli,1YBKJ@1357|Lactococcus 91061|Bacilli K Transcriptional regulatory protein, C terminal phoP - - ko:K07658 ko02020,map02020 M00434 - - ko00000,ko00001,ko00002,ko02022 - - - Response_reg,Trans_reg_C k59_1202960_1 1121935.AQXX01000136_gene4028 9.38e-32 125.0 COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,1RMBS@1236|Gammaproteobacteria,1XHC9@135619|Oceanospirillales 135619|Oceanospirillales NU Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB pilB - - ko:K02454,ko:K02652 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02035,ko02044 3.A.15,3.A.15.2 - - T2SSE,T2SSE_N k59_694269_1 1117319.PSPO_19331 3.72e-46 159.0 COG2890@1|root,COG2890@2|Bacteria,1MXCQ@1224|Proteobacteria,1RNGK@1236|Gammaproteobacteria,2Q1ED@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria J Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif prmC GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006415,GO:0006464,GO:0006479,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008213,GO:0008276,GO:0008757,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0010468,GO:0016043,GO:0016740,GO:0016741,GO:0018364,GO:0019222,GO:0019538,GO:0022411,GO:0032259,GO:0032984,GO:0034641,GO:0034645,GO:0036009,GO:0036211,GO:0043043,GO:0043170,GO:0043412,GO:0043414,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0060255,GO:0065007,GO:0071704,GO:0071840,GO:0140096,GO:1901564,GO:1901566,GO:1901576 2.1.1.297 ko:K02493 - - R10806 RC00003,RC03279 ko00000,ko01000,ko03012 - - - MTS,Methyltransf_31 k59_129715_1 404589.Anae109_1588 2.61e-120 365.0 COG2838@1|root,COG2838@2|Bacteria,1MV6Q@1224|Proteobacteria,42MY0@68525|delta/epsilon subdivisions,2WM7X@28221|Deltaproteobacteria,2YUEI@29|Myxococcales 28221|Deltaproteobacteria C Isocitrate dehydrogenase icd - 1.1.1.42 ko:K00031 ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146 M00009,M00010,M00173,M00740 R00267,R00268,R01899 RC00001,RC00084,RC00114,RC00626,RC02801 br01601,ko00000,ko00001,ko00002,ko01000 - - - IDH k59_411662_1 1463887.KL590059_gene4586 1.23e-51 181.0 COG1574@1|root,COG1574@2|Bacteria,2GJVW@201174|Actinobacteria 201174|Actinobacteria E amidohydrolase - - - - - - - - - - - - Amidohydro_3 k59_1145980_1 1207058.L53_16540 1.4e-28 123.0 COG0689@1|root,COG2931@1|root,COG3898@1|root,COG0689@2|Bacteria,COG2931@2|Bacteria,COG3898@2|Bacteria,1MU7T@1224|Proteobacteria,2TRVY@28211|Alphaproteobacteria,43ZG4@69657|Hyphomonadaceae 28211|Alphaproteobacteria Q COG2931 RTX toxins and related Ca2 -binding proteins - - - - - - - - - - - - DUF4214,HCBP_related,He_PIG,HemolysinCabind,P_proprotein,Peptidase_S8 k59_1612296_1 926561.KB900617_gene1699 2.93e-73 238.0 COG2804@1|root,COG2804@2|Bacteria,1TPGE@1239|Firmicutes,247KA@186801|Clostridia,3WAAY@53433|Halanaerobiales 186801|Clostridia NU PFAM type II secretion system protein E - - - ko:K02652 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - T2SSE,T2SSE_N k59_878955_1 76114.ebA4027 1.19e-78 248.0 COG1797@1|root,COG1797@2|Bacteria,1MV7Z@1224|Proteobacteria,2VI93@28216|Betaproteobacteria,2KV53@206389|Rhodocyclales 206389|Rhodocyclales H Cobyrinic acid ac-diamide synthase cobB - 6.3.5.11,6.3.5.9 ko:K02224 ko00860,ko01100,ko01120,map00860,map01100,map01120 - R05224,R05815 RC00010,RC01301 ko00000,ko00001,ko01000 - - - CbiA,GATase_3 k59_1557219_3 1122137.AQXF01000001_gene2798 5.98e-54 170.0 COG3255@1|root,COG3255@2|Bacteria,1N0RD@1224|Proteobacteria,2UBXK@28211|Alphaproteobacteria 28211|Alphaproteobacteria I sterol carrier protein - - - - - - - - - - - - SCP2 k59_1500346_2 1144313.PMI10_02208 4.39e-16 71.6 COG3655@1|root,COG3655@2|Bacteria,4NVSP@976|Bacteroidetes,1I5EX@117743|Flavobacteriia 976|Bacteroidetes K Cro/C1-type HTH DNA-binding domain - - - ko:K07727 - - - - ko00000,ko03000 - - - HTH_26 k59_31100_1 436308.Nmar_1567 6.52e-138 395.0 COG0077@1|root,arCOG00255@2157|Archaea,41SA8@651137|Thaumarchaeota 651137|Thaumarchaeota E Prephenate dehydratase - - 4.2.1.51 ko:K04518 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00024 R00691,R01373 RC00360 ko00000,ko00001,ko00002,ko01000 - - - ACT,PDT k59_595318_1 1282362.AEAC466_10300 4.94e-58 200.0 COG3451@1|root,COG3451@2|Bacteria,1MXH0@1224|Proteobacteria,2TR1U@28211|Alphaproteobacteria,2KEYI@204458|Caulobacterales 204458|Caulobacterales U Type VI secretion protein - - - ko:K03199 ko03070,map03070 M00333 - - ko00000,ko00001,ko00002,ko02044 3.A.7 - - CagE_TrbE_VirB k59_595318_2 517722.AEUE01000007_gene481 3.34e-20 92.4 COG3704@1|root,COG3704@2|Bacteria,1R9F8@1224|Proteobacteria,2U0XT@28211|Alphaproteobacteria,2K3FA@204457|Sphingomonadales 204457|Sphingomonadales U TrbL/VirB6 plasmid conjugal transfer protein - - - ko:K03201 ko03070,map03070 M00333 - - ko00000,ko00001,ko00002,ko02044 3.A.7 - - TrbL k59_1557233_1 591157.SSLG_02169 1.48e-08 60.8 COG2124@1|root,COG2124@2|Bacteria,2GK4Z@201174|Actinobacteria 201174|Actinobacteria Q cytochrome P450 - - - ko:K21164 ko01059,ko01130,map01059,map01130 M00824 - - ko00000,ko00001,ko00002 - - - p450 k59_1159043_1 1178482.BJB45_05280 9.21e-67 219.0 COG0129@1|root,COG0129@2|Bacteria,1MV4I@1224|Proteobacteria,1RRRD@1236|Gammaproteobacteria 1236|Gammaproteobacteria EG Belongs to the IlvD Edd family - - 4.2.1.25,4.2.1.9 ko:K01687,ko:K13875 ko00053,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00053,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R01209,R02522,R04441,R05070 RC00468,RC00543,RC01714 ko00000,ko00001,ko00002,ko01000 - - - ILVD_EDD k59_1159043_2 266779.Meso_1063 1.96e-25 103.0 COG0684@1|root,COG0684@2|Bacteria,1QSHP@1224|Proteobacteria,2U948@28211|Alphaproteobacteria,43K4G@69277|Phyllobacteriaceae 28211|Alphaproteobacteria H Aldolase/RraA - - - - - - - - - - - - RraA-like k59_1557240_1 1122137.AQXF01000006_gene687 4.51e-136 389.0 COG4786@1|root,COG4786@2|Bacteria,1MVMA@1224|Proteobacteria,2TRR4@28211|Alphaproteobacteria 28211|Alphaproteobacteria N Belongs to the flagella basal body rod proteins family flgG - - ko:K02392 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - Flg_bb_rod,Flg_bbr_C k59_1724932_1 1229909.NSED_05805 1.04e-116 352.0 COG0168@1|root,COG0517@1|root,arCOG00606@2157|Archaea,arCOG04145@2157|Archaea,41SZ8@651137|Thaumarchaeota 651137|Thaumarchaeota P CBS domain - - - ko:K03498 - - - - ko00000,ko02000 2.A.38.1,2.A.38.4 - - CBS,TrkH k59_1270272_1 316407.85676914 2.52e-32 120.0 COG0688@1|root,COG0688@2|Bacteria,1MVT4@1224|Proteobacteria,1RN1U@1236|Gammaproteobacteria,3XNZ3@561|Escherichia 1236|Gammaproteobacteria I Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer) psd GO:0003674,GO:0003824,GO:0004609,GO:0006629,GO:0006644,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0071704,GO:0090407,GO:1901576 4.1.1.65 ko:K01613 ko00564,ko01100,ko01110,map00564,map01100,map01110 M00093 R02055 RC00299 ko00000,ko00001,ko00002,ko01000 - - iECNA114_1301.ECNA114_4379,iECSF_1327.ECSF_4049 PS_Dcarbxylase k59_1270272_2 316407.85676913 1.01e-136 418.0 COG1511@1|root,COG3264@1|root,COG1511@2|Bacteria,COG3264@2|Bacteria,1MWSA@1224|Proteobacteria,1RMYY@1236|Gammaproteobacteria,3XNQQ@561|Escherichia 1236|Gammaproteobacteria M Mechanosensitive channel that protects cells against hypoosmotic stress when highly overexpressed. Gates spontaneously in response to increased membrane tension yjeP GO:0005575,GO:0005623,GO:0005886,GO:0006884,GO:0008150,GO:0008361,GO:0009987,GO:0009992,GO:0016020,GO:0016043,GO:0019725,GO:0030104,GO:0032535,GO:0042592,GO:0044464,GO:0048878,GO:0055082,GO:0065007,GO:0065008,GO:0071840,GO:0071944,GO:0090066 - ko:K05802,ko:K22051 - - - - ko00000,ko02000 1.A.23.1.1,1.A.23.1.2,1.A.23.1.3 - - MS_channel,MscS_TM,MscS_porin k59_595343_1 1408304.JAHA01000019_gene2518 3.08e-05 51.2 COG0454@1|root,COG0546@1|root,COG0456@2|Bacteria,COG0546@2|Bacteria,1V1FQ@1239|Firmicutes,24G1U@186801|Clostridia,4BZ6P@830|Butyrivibrio 186801|Clostridia K haloacid dehalogenase-like hydrolase nt5e - 3.1.3.18 ko:K01091 ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130 - R01334 RC00017 ko00000,ko00001,ko01000 - - - HAD_2 k59_479268_1 1268068.PG5_57630 5.04e-37 136.0 COG1960@1|root,COG1960@2|Bacteria,1N05C@1224|Proteobacteria,1RYCC@1236|Gammaproteobacteria 1236|Gammaproteobacteria I COG1960 Acyl-CoA dehydrogenases - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_479268_2 279238.Saro_3760 3.21e-53 176.0 COG1028@1|root,COG1028@2|Bacteria,1MXNQ@1224|Proteobacteria,2TUHP@28211|Alphaproteobacteria,2K2MX@204457|Sphingomonadales 204457|Sphingomonadales IQ Belongs to the short-chain dehydrogenases reductases (SDR) family - - - - - - - - - - - - adh_short k59_31143_1 1122137.AQXF01000007_gene3532 1.96e-39 139.0 COG0136@1|root,COG0136@2|Bacteria,1MUHG@1224|Proteobacteria,2TSRD@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate asd - 1.2.1.11 ko:K00133 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00017,M00018,M00033,M00525,M00526,M00527 R02291 RC00684 ko00000,ko00001,ko00002,ko01000 - - - Semialdhyde_dh,Semialdhyde_dhC k59_1159071_1 338963.Pcar_3001 4.21e-59 204.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MQ0@68525|delta/epsilon subdivisions,2WJ2A@28221|Deltaproteobacteria,43SE5@69541|Desulfuromonadales 28221|Deltaproteobacteria V AcrB/AcrD/AcrF family - - - - - - - - - - - - ACR_tran k59_423703_1 1134413.ANNK01000091_gene68 8.92e-12 70.5 COG0277@1|root,COG0277@2|Bacteria,1TPBC@1239|Firmicutes,4H9UU@91061|Bacilli,1ZCQN@1386|Bacillus 91061|Bacilli C Glycolate oxidase subunit dld - 1.1.2.4 ko:K00102 ko00620,map00620 - R00197 RC00044 ko00000,ko00001,ko01000 - - - FAD-oxidase_C,FAD_binding_4 k59_1439722_1 329726.AM1_2481 6.47e-39 145.0 COG0654@1|root,COG0654@2|Bacteria,1G27V@1117|Cyanobacteria 1117|Cyanobacteria CH Monooxygenase fad-binding protein - - - - - - - - - - - - FAD_binding_3 k59_88312_1 1121324.CLIT_8c00260 9.6e-68 220.0 COG0547@1|root,COG0547@2|Bacteria,1TP8U@1239|Firmicutes,247WY@186801|Clostridia 186801|Clostridia E Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA) trpD - 2.4.2.18,4.1.3.27 ko:K00766,ko:K13497 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00023 R00985,R00986,R01073 RC00010,RC00440,RC02148,RC02414 ko00000,ko00001,ko00002,ko01000 - - - Glycos_trans_3N,Glycos_transf_3 k59_1666986_1 1122137.AQXF01000002_gene582 1.8e-123 354.0 COG0522@1|root,COG0522@2|Bacteria,1MW0U@1224|Proteobacteria,2TRQH@28211|Alphaproteobacteria 28211|Alphaproteobacteria J One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit rpsD GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006417,GO:0006450,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0015935,GO:0019222,GO:0019843,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0032991,GO:0034248,GO:0034250,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0045727,GO:0045903,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060255,GO:0065007,GO:0065008,GO:0080090,GO:0097159,GO:1901363,GO:1990904,GO:2000112 - ko:K02986 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S4,S4 k59_761590_1 1122137.AQXF01000002_gene351 9.83e-51 168.0 COG1651@1|root,COG1651@2|Bacteria,1MY3H@1224|Proteobacteria,2TTXR@28211|Alphaproteobacteria 28211|Alphaproteobacteria O Dsba oxidoreductase - - - - - - - - - - - - DSBA k59_761590_2 1122137.AQXF01000002_gene352 4.98e-165 466.0 COG2022@1|root,COG2022@2|Bacteria,1N0N5@1224|Proteobacteria,2TSXS@28211|Alphaproteobacteria 28211|Alphaproteobacteria H Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S thiG - 2.8.1.10 ko:K03149 ko00730,ko01100,map00730,map01100 - R10247 RC03096,RC03097,RC03461 ko00000,ko00001,ko01000 - - - ThiG,ThiS k59_1439730_1 981369.JQMJ01000004_gene2080 5.97e-85 274.0 COG0243@1|root,COG0243@2|Bacteria,2GJCK@201174|Actinobacteria,2NFYD@228398|Streptacidiphilus 201174|Actinobacteria C Molybdopterin oxidoreductase Fe4S4 domain - - - ko:K00372,ko:K02567 ko00910,ko01120,map00910,map01120 M00529,M00530,M00531 R00798,R01106 RC02812 ko00000,ko00001,ko00002,ko01000 - - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding k59_1270307_1 519989.ECTPHS_11472 2.18e-79 259.0 COG2609@1|root,COG2609@2|Bacteria,1MV21@1224|Proteobacteria,1RN6K@1236|Gammaproteobacteria,1WWE0@135613|Chromatiales 135613|Chromatiales C Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) aceE - 1.2.4.1 ko:K00163 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200 M00307 R00014,R00209,R01699,R03270 RC00004,RC00027,RC00627,RC02742,RC02744,RC02882 br01601,ko00000,ko00001,ko00002,ko01000 - - - Transketolase_N k59_88325_1 1088721.NSU_1240 1.31e-105 337.0 COG5276@1|root,COG5276@2|Bacteria,1R66X@1224|Proteobacteria,2U4DF@28211|Alphaproteobacteria,2K18I@204457|Sphingomonadales 204457|Sphingomonadales S LVIVD repeat - - - - - - - - - - - - LVIVD k59_31179_2 1229909.NSED_01245 4.63e-154 441.0 arCOG08783@1|root,arCOG08783@2157|Archaea,41SFX@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_879046_1 702113.PP1Y_AT37133 3.68e-50 169.0 COG1597@1|root,COG1597@2|Bacteria,1RGHZ@1224|Proteobacteria,2U7RG@28211|Alphaproteobacteria,2K2EV@204457|Sphingomonadales 204457|Sphingomonadales I COG1597 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase - - - - - - - - - - - - DAGK_cat k59_879046_2 1088721.NSU_1669 2.11e-09 55.1 29GQI@1|root,3181U@2|Bacteria,1P6Y8@1224|Proteobacteria,2UX71@28211|Alphaproteobacteria,2K7W7@204457|Sphingomonadales 204457|Sphingomonadales - - - - - - - - - - - - - - - k59_708601_1 199310.c3920 3.62e-134 400.0 COG1185@1|root,COG1185@2|Bacteria,1MVB9@1224|Proteobacteria,1RNBF@1236|Gammaproteobacteria,3XN31@561|Escherichia 1236|Gammaproteobacteria J Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction pnp GO:0000166,GO:0000175,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004518,GO:0004527,GO:0004532,GO:0004540,GO:0004654,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0008408,GO:0009056,GO:0009057,GO:0009266,GO:0009408,GO:0009628,GO:0009892,GO:0009987,GO:0010468,GO:0010605,GO:0010629,GO:0016070,GO:0016071,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016796,GO:0016896,GO:0017076,GO:0019001,GO:0019222,GO:0019439,GO:0030551,GO:0032553,GO:0032555,GO:0032561,GO:0034641,GO:0034655,GO:0035438,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0050896,GO:0060255,GO:0065007,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0097159,GO:0097367,GO:0140098,GO:1901265,GO:1901360,GO:1901361,GO:1901363,GO:1901575 2.7.7.8 ko:K00962 ko00230,ko00240,ko03018,map00230,map00240,map03018 M00394 R00437,R00438,R00439,R00440 RC02795 ko00000,ko00001,ko00002,ko01000,ko03016,ko03019 - - - KH_1,PNPase,RNase_PH,RNase_PH_C,S1 k59_31182_1 78245.Xaut_0082 1.18e-20 94.0 COG3604@1|root,COG3604@2|Bacteria,1QTT3@1224|Proteobacteria,2TW04@28211|Alphaproteobacteria,3F0I5@335928|Xanthobacteraceae 28211|Alphaproteobacteria KT GAF domain nifA - - ko:K02584 ko02020,map02020 - - - ko00000,ko00001,ko03000 - - - GAF,HTH_8,Sigma54_activat k59_1101353_1 1207063.P24_14354 2.96e-99 299.0 COG1473@1|root,COG1473@2|Bacteria,1MUIV@1224|Proteobacteria,2TR5B@28211|Alphaproteobacteria,2JPY3@204441|Rhodospirillales 204441|Rhodospirillales S Psort location Cytoplasmic, score 7.50 - - - - - - - - - - - - M20_dimer,Peptidase_M20 k59_88329_1 935866.JAER01000003_gene1345 7.6e-96 306.0 COG1132@1|root,COG1132@2|Bacteria,2GITR@201174|Actinobacteria,4DNXB@85009|Propionibacteriales 201174|Actinobacteria V ABC transporter transmembrane region - - - ko:K06147 - - - - ko00000,ko02000 3.A.1.106,3.A.1.109,3.A.1.21 - - ABC_membrane,ABC_tran k59_1724981_1 62928.azo3218 2.71e-60 197.0 COG0014@1|root,COG0014@2|Bacteria,1MUGJ@1224|Proteobacteria,2VJ5M@28216|Betaproteobacteria,2KUNP@206389|Rhodocyclales 206389|Rhodocyclales E Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate proA - 1.2.1.41 ko:K00147 ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230 M00015 R03313 RC00684 ko00000,ko00001,ko00002,ko01000 - - - Aldedh k59_423733_1 247634.GPB2148_1903 1.27e-11 65.5 28HMZ@1|root,2Z7WD@2|Bacteria,1MU3Q@1224|Proteobacteria,1RRUM@1236|Gammaproteobacteria,1J5AG@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Protein of unknown function (DUF3604) - - - - - - - - - - - - DUF3604 k59_423733_2 1121937.AUHJ01000001_gene571 1.03e-40 141.0 COG1051@1|root,COG1051@2|Bacteria,1QUPQ@1224|Proteobacteria,1S69K@1236|Gammaproteobacteria 1236|Gammaproteobacteria F COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes - - - - - - - - - - - - NUDIX k59_1558672_1 1123392.AQWL01000002_gene1978 1.53e-80 267.0 COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2VHFI@28216|Betaproteobacteria,1KSKV@119069|Hydrogenophilales 119069|Hydrogenophilales V MMPL family - - - - - - - - - - - - ACR_tran k59_1725887_1 414684.RC1_2452 1.33e-13 70.9 COG3258@1|root,COG3258@2|Bacteria,1MZJW@1224|Proteobacteria,2UCKE@28211|Alphaproteobacteria,2JX7A@204441|Rhodospirillales 204441|Rhodospirillales C Protein of unknown function (DUF3365) - - - - - - - - - - - - DUF3365 k59_1440705_1 1229909.NSED_04760 2.41e-85 261.0 COG1378@1|root,arCOG02037@2157|Archaea,41T5N@651137|Thaumarchaeota 651137|Thaumarchaeota K transcriptional - - - - - - - - - - - - TrmB k59_257288_1 754476.Q7A_3058 8.95e-35 125.0 COG0689@1|root,COG0689@2|Bacteria,1MVFZ@1224|Proteobacteria,1RNTB@1236|Gammaproteobacteria,45ZZN@72273|Thiotrichales 72273|Thiotrichales J Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates rph - 2.7.7.56 ko:K00989 - - - - ko00000,ko01000,ko03016 - - - RNase_PH,RNase_PH_C k59_257288_2 180281.CPCC7001_2175 4.02e-15 73.6 COG0127@1|root,COG0127@2|Bacteria,1GDNS@1117|Cyanobacteria,22SMQ@167375|Cyanobium 1117|Cyanobacteria F Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions - - - - - - - - - - - - Ham1p_like k59_480195_1 933262.AXAM01000016_gene185 5.2e-46 166.0 COG0729@1|root,COG0729@2|Bacteria,1MUKM@1224|Proteobacteria,42MB2@68525|delta/epsilon subdivisions,2WJAF@28221|Deltaproteobacteria,2MN15@213118|Desulfobacterales 28221|Deltaproteobacteria M POTRA domain TamA domain 1 - - - ko:K07277,ko:K07278 - - - - ko00000,ko02000,ko03029 1.B.33,1.B.33.2.4 - - Bac_surface_Ag,POTRA,POTRA_TamA_1 k59_596706_1 1122137.AQXF01000001_gene3023 1.07e-178 523.0 COG0532@1|root,COG0532@2|Bacteria,1MV26@1224|Proteobacteria,2TQMY@28211|Alphaproteobacteria 28211|Alphaproteobacteria J One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex infB - - ko:K02519 - - - - ko00000,ko03012,ko03029 - - - GTP_EFTU,GTP_EFTU_D2,IF-2,IF2_N,IF2_assoc k59_709878_2 1217718.ALOU01000066_gene1927 3.77e-62 205.0 COG0702@1|root,COG0702@2|Bacteria,1MW54@1224|Proteobacteria,2VIBZ@28216|Betaproteobacteria,1K0ZM@119060|Burkholderiaceae 28216|Betaproteobacteria GM Nad-dependent epimerase dehydratase - - 1.6.5.3,1.6.99.3 ko:K00329,ko:K00356 ko00190,map00190 - R11945 RC00061 ko00000,ko00001,ko01000 - - - Epimerase,NAD_binding_10 k59_1327977_1 754477.Q7C_402 9e-47 168.0 COG3769@1|root,COG4240@1|root,COG3769@2|Bacteria,COG4240@2|Bacteria,1NFV5@1224|Proteobacteria,1RR9R@1236|Gammaproteobacteria,460RR@72273|Thiotrichales 72273|Thiotrichales S HAD-superfamily hydrolase, subfamily IIB - - 2.7.1.31,3.1.3.70 ko:K07026,ko:K15918 ko00051,ko00260,ko00561,ko00630,ko01100,ko01110,ko01130,ko01200,map00051,map00260,map00561,map00630,map01100,map01110,map01130,map01200 M00532 R01514,R05790 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - Hydrolase_3 k59_1217932_1 1205680.CAKO01000010_gene3896 8.74e-63 198.0 COG3812@1|root,COG3812@2|Bacteria,1RGUV@1224|Proteobacteria,2U9BA@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Protein conserved in bacteria - - - ko:K09983 - - - - ko00000 - - - DUF1993 k59_1725902_1 158500.BV97_00556 1.22e-21 90.1 COG4961@1|root,COG4961@2|Bacteria,1N0M1@1224|Proteobacteria,2UCUG@28211|Alphaproteobacteria,2K6NY@204457|Sphingomonadales 204457|Sphingomonadales U overlaps another CDS with the same product name - - - - - - - - - - - - TadE k59_1725902_2 702113.PP1Y_AT20711 6.32e-59 189.0 COG4961@1|root,COG4961@2|Bacteria,1N654@1224|Proteobacteria,2U9MJ@28211|Alphaproteobacteria,2K5IF@204457|Sphingomonadales 204457|Sphingomonadales U overlaps another CDS with the same product name - - - - - - - - - - - - TadE k59_1558695_1 891974.E05_24630 4.01e-30 119.0 COG0318@1|root,COG0318@2|Bacteria 2|Bacteria IQ PFAM AMP-dependent synthetase and ligase - - - ko:K00666 - - - - ko00000,ko01000,ko01004 - - - AMP-binding,LuxE k59_480207_1 1229909.NSED_07250 1.18e-125 377.0 COG1042@1|root,arCOG01338@2157|Archaea,arCOG01340@2157|Archaea,41S7I@651137|Thaumarchaeota 651137|Thaumarchaeota C Succinyl-CoA ligase like flavodoxin domain - - - ko:K18594 ko00720,ko01120,map00720,map01120 - R03157 RC00004,RC00014 ko00000,ko00001,ko01000 - - - ATP-grasp_5,CoA_binding_2,Succ_CoA_lig k59_880358_1 926554.KI912628_gene2716 2.35e-25 100.0 COG3467@1|root,COG3467@2|Bacteria 2|Bacteria T pyridoxamine 5'-phosphate - - - ko:K07005 - - - - ko00000 - - - Pyridox_ox_2 k59_880358_2 1121930.AQXG01000007_gene409 2.26e-11 60.8 COG1695@1|root,COG1695@2|Bacteria,4PK5I@976|Bacteroidetes,1IZJS@117747|Sphingobacteriia 976|Bacteroidetes K PFAM Transcriptional regulator PadR N-terminal-like - - - - - - - - - - - - PadR k59_1440720_1 1122194.AUHU01000003_gene2391 8.3e-69 221.0 COG0577@1|root,COG0577@2|Bacteria,1MX7X@1224|Proteobacteria,1RRH7@1236|Gammaproteobacteria 1236|Gammaproteobacteria V ABC-type antimicrobial peptide transport system, permease component - - - ko:K02004 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - FtsX,MacB_PCD k59_596731_1 1394178.AWOO02000023_gene5468 5.7e-45 159.0 COG0318@1|root,COG0318@2|Bacteria,2GJAA@201174|Actinobacteria,4EIDS@85012|Streptosporangiales 201174|Actinobacteria IQ AMP-binding enzyme - - - - - - - - - - - - AMP-binding,AMP-binding_C k59_1049598_1 1535422.ND16A_3875 4.17e-46 168.0 COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,1T234@1236|Gammaproteobacteria,2Q73E@267889|Colwelliaceae 1236|Gammaproteobacteria K Adenylate cyclase - - - - - - - - - - - - TPR_16 k59_1102297_1 228405.HNE_0954 4.02e-64 219.0 COG1680@1|root,COG1680@2|Bacteria,1MVPR@1224|Proteobacteria,2TRWZ@28211|Alphaproteobacteria,43WQS@69657|Hyphomonadaceae 28211|Alphaproteobacteria V COG1680 Beta-lactamase class C and other penicillin binding proteins - - - - - - - - - - - - Beta-lactamase k59_424647_1 471854.Dfer_4907 1.59e-11 60.8 COG1476@1|root,COG1476@2|Bacteria,4NWX1@976|Bacteroidetes 976|Bacteroidetes K Helix-turn-helix XRE-family like proteins - - - - - - - - - - - - HTH_3 k59_1668025_1 1117647.M5M_08015 3.44e-09 56.6 COG3278@1|root,COG3278@2|Bacteria,1MU18@1224|Proteobacteria,1RM7I@1236|Gammaproteobacteria,1J4J5@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Belongs to the heme-copper respiratory oxidase family ccoN GO:0003674,GO:0003824,GO:0004129,GO:0005215,GO:0005488,GO:0005506,GO:0005507,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006119,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008144,GO:0008150,GO:0008152,GO:0008324,GO:0009055,GO:0009060,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015002,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015672,GO:0015975,GO:0015980,GO:0015988,GO:0015990,GO:0016020,GO:0016021,GO:0016310,GO:0016491,GO:0016675,GO:0016676,GO:0016705,GO:0017144,GO:0019411,GO:0019637,GO:0019646,GO:0019693,GO:0019825,GO:0020037,GO:0022857,GO:0022890,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0032991,GO:0034220,GO:0034641,GO:0036094,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0045154,GO:0045333,GO:0046034,GO:0046483,GO:0046872,GO:0046906,GO:0046914,GO:0048037,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0055114,GO:0070069,GO:0070469,GO:0070470,GO:0071704,GO:0071944,GO:0072521,GO:0097159,GO:0098655,GO:0098660,GO:0098662,GO:1901135,GO:1901360,GO:1901363,GO:1901564,GO:1902600 1.9.3.1 ko:K00404 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00156 - - ko00000,ko00001,ko00002,ko01000 3.D.4.3 - - COX1 k59_1668025_2 1121374.KB891581_gene15 1.44e-71 226.0 COG0137@1|root,COG0137@2|Bacteria,1MV0Y@1224|Proteobacteria,1RMEC@1236|Gammaproteobacteria 1236|Gammaproteobacteria E Belongs to the argininosuccinate synthase family. Type argG GO:0000050,GO:0000053,GO:0003674,GO:0003824,GO:0004055,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006575,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0019627,GO:0019752,GO:0034641,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:0072350,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 6.3.4.5 ko:K01940 ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418 M00029,M00844,M00845 R01954 RC00380,RC00629 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Arginosuc_synth k59_1160407_1 1197477.IA57_02065 7.86e-92 271.0 2C852@1|root,32YB2@2|Bacteria,4NM63@976|Bacteroidetes,1I1C4@117743|Flavobacteriia 976|Bacteroidetes S Domain of unknown function (DUF4136) - - - - - - - - - - - - DUF4136 k59_762530_1 1038869.AXAN01000025_gene2502 4.56e-101 300.0 COG0179@1|root,COG0179@2|Bacteria,1MUPF@1224|Proteobacteria,2VI5Z@28216|Betaproteobacteria,1K3RV@119060|Burkholderiaceae 28216|Betaproteobacteria Q Fumarylacetoacetate (FAA) hydrolase family - - - - - - - - - - - - DUF2437,FAA_hydrolase k59_372064_2 583355.Caka_2654 1.73e-29 119.0 COG1192@1|root,COG1192@2|Bacteria,46SKQ@74201|Verrucomicrobia,3K7TC@414999|Opitutae 414999|Opitutae D ATPase MipZ - - - ko:K03496 - - - - ko00000,ko03036,ko04812 - - - AAA_31 k59_1613315_1 395494.Galf_2724 5.7e-48 174.0 COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,2VH8J@28216|Betaproteobacteria,44VKX@713636|Nitrosomonadales 28216|Betaproteobacteria P ATPase, P-type (transporting), HAD superfamily, subfamily IC copF - 3.6.3.54 ko:K17686 ko01524,ko04016,map01524,map04016 - R00086 RC00002 ko00000,ko00001,ko01000 3.A.3.5 - - E1-E2_ATPase,Hydrolase,YHS k59_596762_1 1046627.BZARG_1125 4.52e-58 203.0 COG1074@1|root,COG1074@2|Bacteria,4NEX4@976|Bacteroidetes,1HWZS@117743|Flavobacteriia 976|Bacteroidetes L ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) addA - - - - - - - - - - - Cas_Cas4,PDDEXK_1,UvrD-helicase,UvrD_C k59_424664_1 1150474.JQJI01000002_gene1196 9.83e-45 163.0 COG0747@1|root,COG0747@2|Bacteria,2GC1T@200918|Thermotogae 200918|Thermotogae E PFAM extracellular solute-binding protein, family 5 - - - - - - - - - - - - SBP_bac_5 k59_880402_1 1245475.ANAE01000182_gene1035 9.46e-38 146.0 COG0438@1|root,COG0438@2|Bacteria,2GMXE@201174|Actinobacteria,4EFZS@85012|Streptosporangiales 201174|Actinobacteria M Glycosyl transferase 4-like domain - - - - - - - - - - - - Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1 k59_257355_2 1522072.IL54_3511 1.46e-76 242.0 COG1158@1|root,COG1158@2|Bacteria,1MUCF@1224|Proteobacteria,2TRB4@28211|Alphaproteobacteria,2K1UD@204457|Sphingomonadales 204457|Sphingomonadales K Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template rho - - ko:K03628 ko03018,map03018 - - - ko00000,ko00001,ko03019,ko03021 - - - ATP-synt_ab,Rho_N,Rho_RNA_bind k59_709944_1 1415778.JQMM01000001_gene868 6.3e-55 184.0 COG0773@1|root,COG0773@2|Bacteria,1MV68@1224|Proteobacteria,1RN88@1236|Gammaproteobacteria,1J4RF@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M Belongs to the MurCDEF family murC GO:0000166,GO:0000270,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008763,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0017076,GO:0030203,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034645,GO:0035639,GO:0036094,GO:0042546,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0046872,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576 6.3.2.8 ko:K01924 ko00471,ko00550,ko01100,map00471,map00550,map01100 - R03193 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - iECP_1309.ECP_0093 Mur_ligase,Mur_ligase_C,Mur_ligase_M k59_1734045_1 1168034.FH5T_17460 9.64e-24 95.1 2DB76@1|root,2Z7JZ@2|Bacteria,4NQDC@976|Bacteroidetes,2FSRT@200643|Bacteroidia 976|Bacteroidetes S T4-like virus tail tube protein gp19 - - - - - - - - - - - - Phage_T4_gp19 k59_1734045_2 1131553.JIBI01000019_gene466 9.53e-39 140.0 COG4325@1|root,COG4325@2|Bacteria,1MXTM@1224|Proteobacteria,2VKHS@28216|Betaproteobacteria,373R2@32003|Nitrosomonadales 28216|Betaproteobacteria S Predicted membrane protein (DUF2254) - - - - - - - - - - - - DUF2254 k59_1225944_1 1122137.AQXF01000007_gene3479 1.2e-120 358.0 COG0469@1|root,COG0469@2|Bacteria,1MU21@1224|Proteobacteria,2TRFV@28211|Alphaproteobacteria 28211|Alphaproteobacteria G Belongs to the pyruvate kinase family pyk - 2.7.1.40 ko:K00873 ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230 M00001,M00002,M00049,M00050 R00200,R00430,R01138,R01858,R02320 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - PK,PK_C k59_829518_1 1297569.MESS2_1000038 2.01e-41 148.0 COG0500@1|root,COG2226@2|Bacteria,1NWX3@1224|Proteobacteria,2TURQ@28211|Alphaproteobacteria,43PQD@69277|Phyllobacteriaceae 28211|Alphaproteobacteria Q Methyltransferase - - - - - - - - - - - - Methyltransf_11,Methyltransf_25,Ubie_methyltran k59_543464_2 330214.NIDE0462 7.8e-56 191.0 COG4949@1|root,COG4949@2|Bacteria 2|Bacteria S Protein of unknown function (DUF3422) - - - - - - - - - - - - DUF3422 k59_1449532_1 926569.ANT_10050 1.31e-77 237.0 COG0088@1|root,COG0088@2|Bacteria,2G6K2@200795|Chloroflexi 200795|Chloroflexi J Forms part of the polypeptide exit tunnel rplD GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02926 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L4 k59_606687_2 1056820.KB900655_gene3654 1.71e-11 63.9 COG2199@1|root,COG2200@1|root,COG2204@1|root,COG2199@2|Bacteria,COG2200@2|Bacteria,COG2204@2|Bacteria,1PJCA@1224|Proteobacteria,1RS4H@1236|Gammaproteobacteria,2PMWW@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria T Putative diguanylate phosphodiesterase - - - ko:K21025 ko02025,map02025 - - - ko00000,ko00001 - - - EAL,GGDEF,PAS,PAS_8,PAS_9,Response_reg k59_829535_1 1122137.AQXF01000003_gene2195 1.72e-65 212.0 COG1749@1|root,COG1749@2|Bacteria,1MU5J@1224|Proteobacteria,2TSF2@28211|Alphaproteobacteria 28211|Alphaproteobacteria N Flagellar hook protein flgE flgE - - ko:K02390 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - FlaE,Flg_bb_rod,Flg_bbr_C k59_1110874_1 1116472.MGMO_18c00060 4.02e-58 188.0 COG0457@1|root,COG0457@2|Bacteria,1R714@1224|Proteobacteria,1SA9Y@1236|Gammaproteobacteria,1XFRQ@135618|Methylococcales 135618|Methylococcales S Tetratricopeptide repeat - - - - - - - - - - - - - k59_941001_1 85643.Tmz1t_3418 1.62e-77 254.0 COG0653@1|root,COG0653@2|Bacteria,1MUJZ@1224|Proteobacteria,2VHDH@28216|Betaproteobacteria,2KVJC@206389|Rhodocyclales 206389|Rhodocyclales U Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane secA - - ko:K03070 ko02024,ko03060,ko03070,map02024,map03060,map03070 M00335 - - ko00000,ko00001,ko00002,ko02044 3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4 - - SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW k59_1568622_1 864051.BurJ1DRAFT_4194 1.78e-44 159.0 COG3292@1|root,COG3292@2|Bacteria,1N0TN@1224|Proteobacteria,2VMZM@28216|Betaproteobacteria,1KNDQ@119065|unclassified Burkholderiales 28216|Betaproteobacteria T Two component regulator propeller - - - - - - - - - - - - Reg_prop k59_658680_1 1121342.AUCO01000008_gene56 2.12e-61 206.0 COG1001@1|root,COG1001@2|Bacteria,1TP84@1239|Firmicutes,247KN@186801|Clostridia,36DDA@31979|Clostridiaceae 186801|Clostridia F Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family ade - 3.5.4.2 ko:K01486 ko00230,ko01100,map00230,map01100 - R01244 RC00477 ko00000,ko00001,ko01000 - - - Adenine_deam_C,Amidohydro_1 k59_1110879_1 392500.Swoo_2109 5.56e-29 117.0 COG2267@1|root,COG2267@2|Bacteria,1QTAP@1224|Proteobacteria,1S6CX@1236|Gammaproteobacteria,2QAX7@267890|Shewanellaceae 1236|Gammaproteobacteria I PFAM alpha beta hydrolase fold - - - - - - - - - - - - Abhydrolase_1,Abhydrolase_6 k59_1336055_1 1158146.KB907122_gene273 6.04e-53 181.0 COG1530@1|root,COG1530@2|Bacteria,1MV65@1224|Proteobacteria,1RMIW@1236|Gammaproteobacteria,1WW9V@135613|Chromatiales 135613|Chromatiales J TIGRFAM ribonuclease, Rne Rng family - - - ko:K08301 - - - - ko00000,ko01000,ko03009,ko03019 - - - RNase_E_G,S1 k59_432535_1 903818.KI912268_gene2561 7.06e-166 485.0 COG0514@1|root,COG0514@2|Bacteria,3Y2KM@57723|Acidobacteria 57723|Acidobacteria L RecQ zinc-binding - - 3.6.4.12 ko:K03654 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03400 - - - DEAD,HRDC,HTH_40,Helicase_C,RecQ_Zn_bind k59_1621476_1 1122185.N792_05495 1.56e-06 49.3 COG0294@1|root,COG0294@2|Bacteria,1MUIR@1224|Proteobacteria,1RM8G@1236|Gammaproteobacteria,1X3ZA@135614|Xanthomonadales 135614|Xanthomonadales H Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives folP - 2.5.1.15 ko:K00796 ko00790,ko01100,map00790,map01100 M00126,M00841 R03066,R03067 RC00121,RC00842 ko00000,ko00001,ko00002,ko01000 - - - Pterin_bind k59_941007_1 436308.Nmar_0004 1.03e-104 313.0 COG3794@1|root,arCOG02926@2157|Archaea 2157|Archaea C PFAM blue (type 1) copper domain protein - - - - - - - - - - - - Copper-bind,Cupredoxin_1 k59_941007_2 436308.Nmar_0003 2.37e-67 208.0 arCOG01995@1|root,arCOG01995@2157|Archaea,41T3M@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - SpoIIM k59_1398143_1 398580.Dshi_1968 1.19e-92 295.0 COG2609@1|root,COG2609@2|Bacteria,1MV21@1224|Proteobacteria,2TSZ9@28211|Alphaproteobacteria 28211|Alphaproteobacteria C Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) aceE - 1.2.4.1 ko:K00163 ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200 M00307 R00014,R00209,R01699,R03270 RC00004,RC00027,RC00627,RC02742,RC02744,RC02882 br01601,ko00000,ko00001,ko00002,ko01000 - - - Biotin_lipoyl,Transketolase_N k59_151842_1 1089544.KB912942_gene6071 3.02e-83 261.0 COG0604@1|root,COG0604@2|Bacteria,2GN47@201174|Actinobacteria,4DZ5G@85010|Pseudonocardiales 201174|Actinobacteria C NAD(P)H quinone oxidoreductase, PIG3 family - - 1.6.5.5 ko:K00344 - - - - ko00000,ko01000 - - - ADH_N,ADH_zinc_N k59_996488_1 713586.KB900536_gene994 2.54e-99 297.0 COG0059@1|root,COG0059@2|Bacteria,1MV7M@1224|Proteobacteria,1RNA8@1236|Gammaproteobacteria,1WWXU@135613|Chromatiales 135613|Chromatiales EH Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate ilvC - 1.1.1.86 ko:K00053 ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R03051,R04439,R04440,R05068,R05069,R05071 RC00726,RC00836,RC00837,RC01726 ko00000,ko00001,ko00002,ko01000 - - - IlvC,IlvN k59_1279480_1 436308.Nmar_0348 5.35e-130 404.0 COG0086@1|root,arCOG04256@2157|Archaea,arCOG04257@2157|Archaea,41SB2@651137|Thaumarchaeota 651137|Thaumarchaeota K DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates rpoA2 - 2.7.7.6 ko:K03041 ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020 M00184 R00435,R00441,R00442,R00443 RC02795 br01611,ko00000,ko00001,ko00002,ko01000,ko03021 - - - RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5 k59_1675997_1 330214.NIDE4191 1.24e-06 48.9 2E2XV@1|root,32XYR@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_1058212_1 1345695.CLSA_c21910 6.77e-17 83.2 COG0784@1|root,COG4191@1|root,COG0784@2|Bacteria,COG4191@2|Bacteria,1TSDF@1239|Firmicutes,250SJ@186801|Clostridia,36UMN@31979|Clostridiaceae 186801|Clostridia T cheY-homologous receiver domain - - - - - - - - - - - - 4HB_MCP_1,GAF_2,HATPase_c,HisKA,Hpt,Response_reg k59_381497_2 493475.GARC_0127 4.6e-07 59.3 COG2885@1|root,COG2982@1|root,COG2885@2|Bacteria,COG2982@2|Bacteria,1MUME@1224|Proteobacteria,1RNPC@1236|Gammaproteobacteria,464KK@72275|Alteromonadaceae 1236|Gammaproteobacteria M Domain of Unknown Function (DUF748) - - - - - - - - - - - - DUF748,OmpA k59_382623_2 795666.MW7_2861 7.17e-29 118.0 COG3745@1|root,COG3745@2|Bacteria,1RG5W@1224|Proteobacteria,2VS1M@28216|Betaproteobacteria,1K4Z3@119060|Burkholderiaceae 28216|Betaproteobacteria U Pilus assembly protein CpaB cpaB - - ko:K02279 - - - - ko00000,ko02035,ko02044 - - - RcpC,SAF k59_1512049_1 314230.DSM3645_14940 1.49e-59 201.0 COG4146@1|root,COG4146@2|Bacteria,2J29I@203682|Planctomycetes 203682|Planctomycetes S Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family - - - - - - - - - - - - SSF k59_830608_1 1415778.JQMM01000001_gene852 4.63e-71 220.0 COG2823@1|root,COG2823@2|Bacteria,1MUZ2@1224|Proteobacteria,1RY2B@1236|Gammaproteobacteria,1J66D@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Periplasmic or secreted yraP GO:0005575,GO:0005623,GO:0009279,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0032153,GO:0044462,GO:0044464,GO:0071944 - - - - - - - - - - BON k59_1677127_1 1229909.NSED_03910 2.88e-59 189.0 COG0640@1|root,arCOG01686@2157|Archaea 2157|Archaea K regulatory protein, arsR - - - - - - - - - - - - HTH_20,HTH_5 k59_433884_1 425104.Ssed_3032 2.07e-73 253.0 COG1596@1|root,COG1596@2|Bacteria,1N7GP@1224|Proteobacteria,1RQSM@1236|Gammaproteobacteria,2Q8WR@267890|Shewanellaceae 1236|Gammaproteobacteria M PFAM polysaccharide export protein - - - ko:K01991 ko02026,map02026 - - - ko00000,ko00001,ko02000 1.B.18 - - Poly_export,SLBB k59_1399399_1 891974.E05_02070 7.03e-42 147.0 COG1181@1|root,COG1181@2|Bacteria,1MUTB@1224|Proteobacteria,1RMTM@1236|Gammaproteobacteria 1236|Gammaproteobacteria F Belongs to the D-alanine--D-alanine ligase family ddl GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008716,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0030203,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576 6.3.2.4 ko:K01921 ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502 - R01150 RC00064,RC00141 ko00000,ko00001,ko01000,ko01011 - - iECO26_1355.ECO26_0095 Dala_Dala_lig_C,Dala_Dala_lig_N k59_720893_1 313596.RB2501_12167 5.29e-05 47.4 2EPER@1|root,33H1D@2|Bacteria,4NZ37@976|Bacteroidetes,1I6B9@117743|Flavobacteriia 976|Bacteroidetes - - - - - - - - - - - - - - - k59_890924_1 1229909.NSED_01530 5.92e-166 473.0 COG0148@1|root,arCOG01169@2157|Archaea,41SE9@651137|Thaumarchaeota 651137|Thaumarchaeota G Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis eno - 4.2.1.11 ko:K01689 ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066 M00001,M00002,M00003,M00346,M00394 R00658 RC00349 ko00000,ko00001,ko00002,ko01000,ko03019,ko04147 - - - Enolase_C,Enolase_N k59_1280457_1 98439.AJLL01000052_gene3635 9.08e-32 133.0 COG0058@1|root,COG0058@2|Bacteria,1G1HB@1117|Cyanobacteria,1JH4T@1189|Stigonemataceae 1117|Cyanobacteria G Protein of unknown function (DUF3417) glgP - 2.4.1.1 ko:K00688 ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931 - R02111 - ko00000,ko00001,ko01000 - GT35 - DUF3417,Phosphorylase k59_1111895_3 1268240.ATFI01000019_gene130 2.06e-32 118.0 COG1595@1|root,COG1595@2|Bacteria,4NQH8@976|Bacteroidetes,2FT5W@200643|Bacteroidia 976|Bacteroidetes K DNA-templated transcription, initiation - - - - - - - - - - - - - k59_382656_1 1459636.NTE_03073 8.11e-60 191.0 arCOG08805@1|root,arCOG08805@2157|Archaea 1459636.NTE_03073|- - - - - - - - - - - - - - - - k59_489584_1 1232410.KI421412_gene119 7.15e-73 230.0 COG0004@1|root,COG0004@2|Bacteria,1NR9F@1224|Proteobacteria,42ZDZ@68525|delta/epsilon subdivisions,2WTXC@28221|Deltaproteobacteria,43TRQ@69541|Desulfuromonadales 28221|Deltaproteobacteria P PFAM Rh family protein ammonium transporter - - - ko:K03320 - - - - ko00000,ko02000 1.A.11 - - Ammonium_transp k59_267929_1 1500893.JQNB01000001_gene1317 2.1e-88 283.0 COG0006@1|root,COG0006@2|Bacteria,1MURT@1224|Proteobacteria,1RMKT@1236|Gammaproteobacteria,1X3Z6@135614|Xanthomonadales 135614|Xanthomonadales E Splits dipeptides with a prolyl residue in the C- terminal position pepQ - 3.4.13.9 ko:K01271 - - - - ko00000,ko01000,ko01002 - - - Peptidase_M24 k59_607657_1 1242864.D187_010061 4.89e-06 53.5 COG0768@1|root,COG0768@2|Bacteria,1R7A0@1224|Proteobacteria,42MJC@68525|delta/epsilon subdivisions,2WJZ2@28221|Deltaproteobacteria,2YV14@29|Myxococcales 28221|Deltaproteobacteria M Cell division protein FtsI penicillin-binding protein 2 pbp4 - - - - - - - - - - - Transpeptidase k59_1677162_1 640081.Dsui_0576 1.6e-87 266.0 COG2086@1|root,COG2086@2|Bacteria,1MVH6@1224|Proteobacteria,2VN3Q@28216|Betaproteobacteria,2KVQQ@206389|Rhodocyclales 206389|Rhodocyclales C Electron transfer flavoprotein domain - - - ko:K03521 - - - - ko00000 - - - ETF k59_771916_1 1229909.NSED_04280 2.55e-40 134.0 arCOG07555@1|root,arCOG07555@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_1399418_1 497321.C664_02695 3.34e-52 171.0 COG0735@1|root,COG0735@2|Bacteria,1RDWJ@1224|Proteobacteria,2VR52@28216|Betaproteobacteria,2KWB1@206389|Rhodocyclales 206389|Rhodocyclales K Belongs to the Fur family fur - - ko:K03711 - - - - ko00000,ko03000 - - - FUR k59_382669_1 220664.PFL_4818 4.04e-22 98.6 COG2207@1|root,COG2207@2|Bacteria,1RM0C@1224|Proteobacteria,1S3EF@1236|Gammaproteobacteria,1YMJS@136843|Pseudomonas fluorescens group 1236|Gammaproteobacteria K Transcriptional regulator pobR - - ko:K18954 - - - - ko00000,ko03000 - - - AraC_binding,HTH_18 k59_1111908_1 1120949.KB903329_gene9217 2.65e-43 161.0 COG2909@1|root,COG2909@2|Bacteria,2IDM6@201174|Actinobacteria,4DCIQ@85008|Micromonosporales 201174|Actinobacteria K helix_turn_helix, Lux Regulon - - - ko:K03556 - - - - ko00000,ko03000 - - - AAA_16,GerE,Pkinase k59_433922_1 436308.Nmar_0409 4.5e-98 297.0 COG0579@1|root,arCOG00754@2157|Archaea,41SXA@651137|Thaumarchaeota 651137|Thaumarchaeota S FAD dependent oxidoreductase - - - ko:K15736 - - - - ko00000,ko01000 - - - DAO k59_997781_1 382464.ABSI01000012_gene2260 1.93e-17 85.9 COG0592@1|root,COG0592@2|Bacteria,46SPK@74201|Verrucomicrobia,2ITMH@203494|Verrucomicrobiae 203494|Verrucomicrobiae L Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria - - 2.7.7.7 ko:K02338 ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440 M00260 R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko00002,ko01000,ko03032,ko03400 - - - DNA_pol3_beta,DNA_pol3_beta_2,DNA_pol3_beta_3 k59_720918_1 1353276.JADR01000003_gene2673 1.36e-99 306.0 COG0322@1|root,COG0322@2|Bacteria,4NE61@976|Bacteroidetes,1HWQN@117743|Flavobacteriia 976|Bacteroidetes L The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision uvrC GO:0005575,GO:0005622,GO:0005623,GO:0006950,GO:0006974,GO:0008150,GO:0009380,GO:0009987,GO:0032991,GO:0033554,GO:0044424,GO:0044464,GO:0050896,GO:0051716,GO:1902494,GO:1905347,GO:1905348,GO:1990391 - ko:K03703 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - GIY-YIG,HHH_2,HHH_5,UVR,UvrC_HhH_N k59_720918_2 983544.Lacal_0814 4.49e-49 173.0 COG1752@1|root,COG4775@1|root,COG1752@2|Bacteria,COG4775@2|Bacteria,4NDXY@976|Bacteroidetes,1HWZP@117743|Flavobacteriia 976|Bacteroidetes M esterase of the alpha-beta hydrolase superfamily - - - ko:K07001 - - - - ko00000 - - - POTRA,Patatin k59_382678_1 316407.85676046 2.04e-97 284.0 COG0511@1|root,COG0511@2|Bacteria,1RCXA@1224|Proteobacteria,1S3YP@1236|Gammaproteobacteria,3XM9J@561|Escherichia 1236|Gammaproteobacteria I first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA accB GO:0003674,GO:0003824,GO:0003989,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009305,GO:0009987,GO:0016049,GO:0016053,GO:0016421,GO:0016874,GO:0016885,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0040007,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0072330,GO:1901564,GO:1901576 - ko:K02160 ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00376 R00742 RC00040,RC00367 ko00000,ko00001,ko00002 - - iYL1228.KPN_03664 Biotin_lipoyl k59_1787218_1 1255043.TVNIR_2798 5.97e-52 172.0 COG1136@1|root,COG1136@2|Bacteria,1MU45@1224|Proteobacteria,1RR3R@1236|Gammaproteobacteria,1WXTU@135613|Chromatiales 135613|Chromatiales V ABC transporter - - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_607672_1 671143.DAMO_1535 1.5e-74 235.0 COG0395@1|root,COG0395@2|Bacteria,2NPBC@2323|unclassified Bacteria 2|Bacteria U Binding-protein-dependent transport system inner membrane component sugB - - ko:K02026,ko:K10238 ko02010,map02010 M00204,M00207 - - ko00000,ko00001,ko00002,ko02000 3.A.1.1,3.A.1.1.17 - - BPD_transp_1 k59_210416_1 556268.OFAG_00821 9.44e-67 227.0 COG5525@1|root,COG5525@2|Bacteria,1NE5I@1224|Proteobacteria 1224|Proteobacteria S Phage terminase large subunit (GpA) - - - - - - - - - - - - Terminase_GpA k59_210416_3 1192759.AKIB01000023_gene2879 7.56e-20 89.7 28P9A@1|root,2ZC2W@2|Bacteria,1N5EH@1224|Proteobacteria,2UE6G@28211|Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_544751_2 1041522.MCOL_V216509 6.64e-08 56.6 COG0596@1|root,COG0596@2|Bacteria,2I8WB@201174|Actinobacteria,235W8@1762|Mycobacteriaceae 201174|Actinobacteria S Alpha beta hydrolase - - - - - - - - - - - - Abhydrolase_1,Abhydrolase_6 k59_489619_1 1117647.M5M_12057 1.99e-38 147.0 COG1729@1|root,COG1729@2|Bacteria,1MX82@1224|Proteobacteria,1T32S@1236|Gammaproteobacteria 1236|Gammaproteobacteria O protein conserved in bacteria - - - - - - - - - - - - TPR_16,TPR_6,TPR_8 k59_1450594_1 1313172.YM304_31920 5.52e-18 90.1 COG0739@1|root,COG0739@2|Bacteria 2|Bacteria M heme binding - - - ko:K21471,ko:K21472 - - - - ko00000,ko01000,ko01002,ko01011 - - - LysM,Peptidase_M23 k59_1512143_1 269799.Gmet_0986 8.1e-21 91.7 COG1427@1|root,COG1427@2|Bacteria,1RCS0@1224|Proteobacteria,42SPW@68525|delta/epsilon subdivisions,2WP7F@28221|Deltaproteobacteria,43U6I@69541|Desulfuromonadales 28221|Deltaproteobacteria H Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2) mqnA - 4.2.1.151 ko:K11782 ko00130,ko01110,map00130,map01110 - R10666 RC03232 ko00000,ko00001,ko01000 - - - VitK2_biosynth k59_1512143_2 1125863.JAFN01000001_gene1316 3.17e-12 67.4 COG1060@1|root,COG1060@2|Bacteria,1QN23@1224|Proteobacteria,42M6Z@68525|delta/epsilon subdivisions,2WJ4C@28221|Deltaproteobacteria 28221|Deltaproteobacteria H Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate mqnE - 1.21.98.1,2.5.1.120,2.5.1.77 ko:K11779,ko:K11784,ko:K18285 ko00130,ko00680,ko01110,ko01120,map00130,map00680,map01110,map01120 M00378 R08588,R09396,R10667 RC00021,RC01381,RC02329,RC03002,RC03007,RC03234 ko00000,ko00001,ko00002,ko01000 - - iAF987.Gmet_3391 Radical_SAM k59_1170952_1 1219045.BV98_001293 1.67e-60 197.0 COG1804@1|root,COG1804@2|Bacteria,1MW1H@1224|Proteobacteria,2TR7D@28211|Alphaproteobacteria,2K1KA@204457|Sphingomonadales 204457|Sphingomonadales C L-carnitine dehydratase bile acid-inducible protein F - - 5.1.99.4 ko:K01796 ko00120,ko01100,ko04146,map00120,map01100,map04146 M00104 R08734,R08739 RC02345 ko00000,ko00001,ko00002,ko01000 - - - CoA_transf_3 k59_1512148_1 1232410.KI421420_gene3172 2.48e-71 228.0 COG4097@1|root,COG4097@2|Bacteria,1MV9P@1224|Proteobacteria,42QJV@68525|delta/epsilon subdivisions,2WK93@28221|Deltaproteobacteria 28221|Deltaproteobacteria C Ferric reductase like transmembrane component - - - - - - - - - - - - FAD_binding_8,Ferric_reduct,NAD_binding_1 k59_210433_1 977880.RALTA_A1666 1.92e-32 124.0 COG0516@1|root,COG0517@1|root,COG0516@2|Bacteria,COG0517@2|Bacteria,1MUJM@1224|Proteobacteria,2VH9X@28216|Betaproteobacteria,1K337@119060|Burkholderiaceae 28216|Betaproteobacteria F Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth guaB - 1.1.1.205 ko:K00088 ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110 M00050 R01130,R08240 RC00143,RC02207 ko00000,ko00001,ko00002,ko01000,ko04147 - - - CBS,IMPDH,NMO k59_830673_1 404589.Anae109_0670 1.25e-12 73.9 COG3852@1|root,COG3852@2|Bacteria,1QVPN@1224|Proteobacteria,42PS3@68525|delta/epsilon subdivisions,2X7MQ@28221|Deltaproteobacteria,2YVCB@29|Myxococcales 28221|Deltaproteobacteria T His Kinase A (phosphoacceptor) domain - - 2.7.13.3 ko:K02668 ko02020,map02020 M00501 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 - - - HATPase_c,HisKA,PAS,PAS_8 k59_607692_1 215803.DB30_7934 2.18e-31 112.0 COG1977@1|root,COG1977@2|Bacteria,1N4M4@1224|Proteobacteria,43BB7@68525|delta/epsilon subdivisions,2X6QD@28221|Deltaproteobacteria,2Z3C9@29|Myxococcales 28221|Deltaproteobacteria H ThiS family - - - - - - - - - - - - ThiS k59_771965_1 314278.NB231_10768 1.18e-66 212.0 COG0218@1|root,COG0218@2|Bacteria,1MY3Z@1224|Proteobacteria,1RNJP@1236|Gammaproteobacteria,1WWX9@135613|Chromatiales 135613|Chromatiales D Necessary for normal cell division and for the maintenance of normal septation engB - - ko:K03978 - - - - ko00000,ko03036 - - - MMR_HSR1 k59_1450606_1 314287.GB2207_08751 3.69e-118 352.0 COG0056@1|root,COG0056@2|Bacteria,1MUG7@1224|Proteobacteria,1RP4V@1236|Gammaproteobacteria,1J5DU@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit atpA GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045261,GO:0045262,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 3.6.3.14 ko:K02111 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - iSbBS512_1146.SbBS512_E4187 ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N k59_544779_1 1522072.IL54_4591 2.54e-27 110.0 COG1609@1|root,COG1609@2|Bacteria,1MVUR@1224|Proteobacteria,2U0SC@28211|Alphaproteobacteria,2K0F6@204457|Sphingomonadales 204457|Sphingomonadales K LacI family - - - ko:K02529 - - - - ko00000,ko03000 - - - LacI,Peripla_BP_3 k59_544779_2 573065.Astex_2132 1.58e-60 195.0 COG3717@1|root,COG3717@2|Bacteria,1MU9D@1224|Proteobacteria,2TSU5@28211|Alphaproteobacteria,2KHY1@204458|Caulobacterales 204458|Caulobacterales G Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate kduI - 5.3.1.17 ko:K01815 ko00040,map00040 - R04383 RC00541 ko00000,ko00001,ko01000 - - - KduI k59_1280539_1 216142.LT40_09225 2.63e-106 321.0 COG1109@1|root,COG1109@2|Bacteria,1MUA5@1224|Proteobacteria,1RMU8@1236|Gammaproteobacteria 1236|Gammaproteobacteria G phosphomannomutase xanA - 5.4.2.2,5.4.2.8 ko:K01840,ko:K15778 ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130 M00114 R00959,R01057,R01818,R08639 RC00408 ko00000,ko00001,ko00002,ko01000 - - - PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV k59_1677218_2 167548.EU98_0277 9.05e-26 102.0 COG4122@1|root,COG4122@2|Bacteria,1G5B0@1117|Cyanobacteria 1117|Cyanobacteria S Methyltransferase domain - - - - - - - - - - - - Methyltransf_24,TPR_2 k59_941997_1 1122169.AREN01000006_gene311 3.35e-24 99.4 COG1521@1|root,COG1521@2|Bacteria,1MUYA@1224|Proteobacteria,1S40S@1236|Gammaproteobacteria,1JDRU@118969|Legionellales 118969|Legionellales F Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis coaX - 2.7.1.33 ko:K03525 ko00770,ko01100,map00770,map01100 M00120 R02971,R03018,R04391 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - Pan_kinase k59_941997_2 945713.IALB_0059 4.7e-43 144.0 COG0853@1|root,COG0853@2|Bacteria 2|Bacteria H Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine panD - 4.1.1.11 ko:K01579 ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110 M00119 R00489 RC00299 ko00000,ko00001,ko00002,ko01000 - - - Asp_decarbox k59_891014_1 199310.c4345 2.85e-18 82.8 COG1215@1|root,COG1215@2|Bacteria,1MWF8@1224|Proteobacteria,1RPJ6@1236|Gammaproteobacteria,3XM9Y@561|Escherichia 1236|Gammaproteobacteria M Catalytic subunit of cellulose synthase. It polymerizes uridine 5'-diphosphate glucose to cellulose, which is produced as an extracellular component for mechanical and chemical protection at the onset of the stationary phase, when the cells exhibit multicellular behavior (rdar morphotype). Coexpression of cellulose and thin aggregative fimbriae bcsA GO:0000271,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0005976,GO:0006073,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0016020,GO:0016051,GO:0030243,GO:0030244,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044464,GO:0051273,GO:0051274,GO:0071704,GO:0071944,GO:0090540,GO:1901576 2.4.1.12 ko:K00694,ko:K20541 ko00500,ko01100,ko02026,map00500,map01100,map02026 - R02889 RC00005 ko00000,ko00001,ko01000,ko01003,ko02000 4.D.3.1.2,4.D.3.1.5,4.D.3.1.6 GT2 - Cellulose_synt,Glyco_hydro_17,Glyco_tranf_2_3,Glycos_transf_2,PilZ k59_1234439_1 518766.Rmar_0491 3.34e-67 219.0 COG4146@1|root,COG4146@2|Bacteria,4NE9S@976|Bacteroidetes,1FJX9@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes S Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family - - - ko:K03307 - - - - ko00000 2.A.21 - - SSF k59_668126_1 1121939.L861_22710 8.95e-91 280.0 COG0031@1|root,COG0031@2|Bacteria,1MUBE@1224|Proteobacteria,1RN6J@1236|Gammaproteobacteria,1XI2N@135619|Oceanospirillales 135619|Oceanospirillales E Belongs to the cysteine synthase cystathionine beta- synthase family - - 2.5.1.47 ko:K01738 ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230 M00021 R00897,R03601,R04859 RC00020,RC02814,RC02821 ko00000,ko00001,ko00002,ko01000 - - - PALP k59_1578859_1 1229909.NSED_07725 2.31e-92 271.0 arCOG01841@1|root,arCOG01841@2157|Archaea,41SPP@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_840033_1 1282876.BAOK01000001_gene2255 1.35e-130 381.0 COG1219@1|root,COG1219@2|Bacteria,1MVQK@1224|Proteobacteria,2TS3R@28211|Alphaproteobacteria,4BPBB@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria O ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP clpX GO:0000166,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005524,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0030163,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0044238,GO:0051301,GO:0070011,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575 - ko:K03544 ko04112,map04112 - - - ko00000,ko00001,ko03110 - - - AAA_2,ClpB_D2-small,zf-C4_ClpX k59_498212_1 981327.F925_00605 7.11e-07 51.6 COG1048@1|root,COG1048@2|Bacteria,1MU9T@1224|Proteobacteria,1RN5I@1236|Gammaproteobacteria,3NKPZ@468|Moraxellaceae 1236|Gammaproteobacteria C Catalyzes the isomerization of citrate to isocitrate via cis-aconitate acnA GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003730,GO:0003824,GO:0003994,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006081,GO:0006082,GO:0006091,GO:0006097,GO:0006099,GO:0006101,GO:0006629,GO:0006631,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009060,GO:0009061,GO:0009987,GO:0015980,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017144,GO:0019541,GO:0019679,GO:0019752,GO:0032787,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044255,GO:0044262,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0046459,GO:0046487,GO:0046872,GO:0046914,GO:0047456,GO:0048037,GO:0050896,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0071704,GO:0072350,GO:0097159,GO:1901363 4.2.1.3 ko:K01681 ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00173,M00740 R01324,R01325,R01900 RC00497,RC00498,RC00618 br01601,ko00000,ko00001,ko00002,ko01000 - - iAPECO1_1312.APECO1_436,iECOK1_1307.ECOK1_1491,iECS88_1305.ECS88_1416,iJN746.PP_2112,iUMN146_1321.UM146_10390,iUTI89_1310.UTI89_C1547 Aconitase,Aconitase_C k59_498212_2 1122137.AQXF01000001_gene3150 1.98e-137 416.0 COG1049@1|root,COG1049@2|Bacteria,1MVCR@1224|Proteobacteria,2TS9P@28211|Alphaproteobacteria 28211|Alphaproteobacteria C aconitate hydratase acnB - 4.2.1.3,4.2.1.99 ko:K01682 ko00020,ko00630,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230 M00009,M00010,M00012,M00173 R01324,R01325,R01900,R04425 RC00497,RC00498,RC00618,RC01153 br01601,ko00000,ko00001,ko00002,ko01000 - - - Aconitase,Aconitase_2_N,Aconitase_B_N k59_1686857_1 159087.Daro_3911 1.35e-25 102.0 COG1968@1|root,COG1968@2|Bacteria,1MX02@1224|Proteobacteria,2VHSA@28216|Betaproteobacteria,2KV15@206389|Rhodocyclales 206389|Rhodocyclales V Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin uppP - 3.6.1.27 ko:K06153 ko00550,map00550 - R05627 RC00002 ko00000,ko00001,ko01000,ko01011 - - - BacA k59_669237_1 1122137.AQXF01000005_gene1322 1.73e-37 135.0 COG1120@1|root,COG1120@2|Bacteria,1QPWJ@1224|Proteobacteria,2U1TK@28211|Alphaproteobacteria 28211|Alphaproteobacteria HP ABC transporter fecE - 3.6.3.34 ko:K02013 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.14 - - ABC_tran k59_669237_2 314225.ELI_07950 1.17e-12 68.2 COG0609@1|root,COG0609@2|Bacteria,1MV9W@1224|Proteobacteria,2TR9A@28211|Alphaproteobacteria,2K0DB@204457|Sphingomonadales 204457|Sphingomonadales P Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily - - - ko:K02015 ko02010,map02010 M00240 - - ko00000,ko00001,ko00002,ko02000 3.A.1.14 - - FecCD k59_107645_1 1123269.NX02_29660 1.83e-12 67.4 COG1595@1|root,COG1595@2|Bacteria,1N00E@1224|Proteobacteria,2U6J3@28211|Alphaproteobacteria,2K57J@204457|Sphingomonadales 204457|Sphingomonadales K Belongs to the sigma-70 factor family. ECF subfamily - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4,Sigma70_r4_2 k59_1521164_1 404589.Anae109_0690 0.000183 43.5 COG4796@1|root,COG4796@2|Bacteria,1QTT6@1224|Proteobacteria,42MKN@68525|delta/epsilon subdivisions,2WJV6@28221|Deltaproteobacteria,2YTV4@29|Myxococcales 28221|Deltaproteobacteria U type IV pilus secretin PilQ pilQ - - ko:K02666 - - - - ko00000,ko02035,ko02044 3.A.15.2 - - AMIN,STN,Secretin,Secretin_N k59_1521164_2 1122137.AQXF01000003_gene1873 1.15e-86 261.0 COG3279@1|root,COG3279@2|Bacteria,1MUE8@1224|Proteobacteria,2TSPC@28211|Alphaproteobacteria 28211|Alphaproteobacteria T Response regulator of the LytR AlgR family - - - ko:K02477 - - - - ko00000,ko02022 - - - LytTR,Response_reg k59_1521164_3 1336233.JAEH01000007_gene2427 1.51e-07 52.4 COG1842@1|root,COG1842@2|Bacteria,1RM3K@1224|Proteobacteria,1SDD3@1236|Gammaproteobacteria 1236|Gammaproteobacteria KT Lecithin retinol acyltransferase - - - - - - - - - - - - LRAT k59_51647_1 911239.CF149_05014 1.4e-90 276.0 COG0137@1|root,COG0137@2|Bacteria,1MV0Y@1224|Proteobacteria,1RMEC@1236|Gammaproteobacteria 1236|Gammaproteobacteria E Belongs to the argininosuccinate synthase family. Type argG GO:0000050,GO:0000053,GO:0003674,GO:0003824,GO:0004055,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006575,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0019627,GO:0019752,GO:0034641,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:0072350,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 6.3.4.5 ko:K01940 ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418 M00029,M00844,M00845 R01954 RC00380,RC00629 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Arginosuc_synth k59_1521177_1 399739.Pmen_0965 4.96e-85 264.0 COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,1YDVE@136841|Pseudomonas aeruginosa group 1236|Gammaproteobacteria T Bacterial regulatory protein, Fis family pilR - - ko:K02481,ko:K02667 ko02020,map02020 M00501 - - ko00000,ko00001,ko00002,ko02022,ko02035 - - - HTH_8,Response_reg,Sigma54_activat k59_669245_1 1288298.rosmuc_03651 3.44e-76 240.0 COG1319@1|root,COG1319@2|Bacteria,1RCRH@1224|Proteobacteria,2TU08@28211|Alphaproteobacteria,46P3Y@74030|Roseovarius 28211|Alphaproteobacteria C COG1319 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM CutM homologs xdhB - 1.2.5.3 ko:K03519 - - R11168 RC02800 ko00000,ko01000 - - - CO_deh_flav_C,FAD_binding_5 k59_51664_1 1122137.AQXF01000005_gene1106 3.04e-67 216.0 COG1322@1|root,COG1322@2|Bacteria,1MWHV@1224|Proteobacteria,2TTX6@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Protein conserved in bacteria rmuC - - ko:K09760 - - - - ko00000 - - - RmuC k59_51664_2 983544.Lacal_2170 8.23e-54 171.0 COG0346@1|root,COG0346@2|Bacteria,4NQIE@976|Bacteroidetes,1I2UJ@117743|Flavobacteriia 976|Bacteroidetes E glyoxalase - - - - - - - - - - - - Glyoxalase k59_51664_3 1122137.AQXF01000005_gene1105 9.25e-24 92.4 COG2841@1|root,COG2841@2|Bacteria,1NNR7@1224|Proteobacteria,2UFB8@28211|Alphaproteobacteria 28211|Alphaproteobacteria S protein conserved in bacteria - - - ko:K09794 - - - - ko00000 - - - DUF465 k59_1235457_2 757424.Hsero_4198 1.61e-91 276.0 COG0451@1|root,COG0451@2|Bacteria,1MVI8@1224|Proteobacteria,2WEQP@28216|Betaproteobacteria 28216|Betaproteobacteria M Male sterility protein - - 5.1.3.2 ko:K01784 ko00052,ko00520,ko01100,map00052,map00520,map01100 M00361,M00362,M00632 R00291,R02984 RC00289 ko00000,ko00001,ko00002,ko01000 - - - Epimerase k59_219255_1 1089552.KI911559_gene301 1.04e-57 204.0 COG1132@1|root,COG1132@2|Bacteria,1MWTY@1224|Proteobacteria,2TRSY@28211|Alphaproteobacteria,2JPPS@204441|Rhodospirillales 204441|Rhodospirillales V ABC transporter transmembrane region - - - ko:K02021 - - - - ko00000,ko02000 3.A.1.106,3.A.1.110,3.A.1.112,3.A.1.113,3.A.1.117,3.A.1.21 - - ABC_membrane,ABC_tran,cNMP_binding k59_780510_1 1123393.KB891332_gene2834 6.97e-133 403.0 COG1529@1|root,COG1529@2|Bacteria,1QTTJ@1224|Proteobacteria,2VHB9@28216|Betaproteobacteria,1KRIV@119069|Hydrogenophilales 119069|Hydrogenophilales C Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain - - - - - - - - - - - - Ald_Xan_dh_C2 k59_554040_1 1300345.LF41_3143 5.58e-87 271.0 COG0031@1|root,COG0031@2|Bacteria,1MUBE@1224|Proteobacteria,1RN6J@1236|Gammaproteobacteria,1X393@135614|Xanthomonadales 135614|Xanthomonadales E Belongs to the cysteine synthase cystathionine beta- synthase family - - - - - - - - - - - - PALP k59_498255_1 289377.HL41_04105 2.64e-18 86.7 COG1475@1|root,COG1475@2|Bacteria,2GGT2@200940|Thermodesulfobacteria 200940|Thermodesulfobacteria K Belongs to the ParB family - - - ko:K03497 - - - - ko00000,ko03000,ko03036,ko04812 - - - ParBc k59_1120846_1 392499.Swit_3825 8.7e-70 231.0 COG0758@1|root,COG0758@2|Bacteria,1MVF6@1224|Proteobacteria,2TRQE@28211|Alphaproteobacteria,2K08N@204457|Sphingomonadales 204457|Sphingomonadales LU Rossmann fold nucleotide-binding protein involved in DNA uptake dprA - - ko:K04096 - - - - ko00000 - - - DNA_processg_A k59_1120846_2 991905.SL003B_1846 3.41e-36 136.0 COG0550@1|root,COG1754@1|root,COG0550@2|Bacteria,COG1754@2|Bacteria,1MUFZ@1224|Proteobacteria,2TRGN@28211|Alphaproteobacteria,4BPJJ@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria L Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone topA - 5.99.1.2 ko:K03168 - - - - ko00000,ko01000,ko03032,ko03400 - - - Topoisom_bac,Toprim,Toprim_C_rpt,zf-C4_Topoisom k59_617224_1 1449076.JOOE01000002_gene1482 2.69e-28 115.0 COG2367@1|root,COG2367@2|Bacteria,1RAH0@1224|Proteobacteria,2U6HN@28211|Alphaproteobacteria,2K024@204457|Sphingomonadales 204457|Sphingomonadales V Beta-lactamase enzyme family - - - - - - - - - - - - Beta-lactamase2 k59_219289_1 643867.Ftrac_1047 1.24e-18 84.7 COG3271@1|root,COG3271@2|Bacteria,4NN8E@976|Bacteroidetes 976|Bacteroidetes - - - - - - - - - - - - - - Peptidase_C39_2 k59_219289_2 1232410.KI421415_gene2975 1.55e-15 76.3 COG0189@1|root,COG0189@2|Bacteria,1MX5X@1224|Proteobacteria,42MPG@68525|delta/epsilon subdivisions,2WKW8@28221|Deltaproteobacteria,43UK8@69541|Desulfuromonadales 28221|Deltaproteobacteria HJ RimK-like ATPgrasp N-terminal domain - - - - - - - - - - - - Acetyltransf_1,Dala_Dala_lig_C,RLAN,RimK k59_1578933_1 547163.BN979_00161 5.62e-63 210.0 COG0318@1|root,COG0318@2|Bacteria,2GJA2@201174|Actinobacteria,232FY@1762|Mycobacteriaceae 201174|Actinobacteria IQ COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II fadD19_2 - - ko:K00666 - - - - ko00000,ko01000,ko01004 - - - AMP-binding,AMP-binding_C k59_951138_1 1173264.KI913949_gene3779 2.96e-23 100.0 COG2114@1|root,COG2199@1|root,COG2114@2|Bacteria,COG3706@2|Bacteria,1FZXP@1117|Cyanobacteria,1H71W@1150|Oscillatoriales 1117|Cyanobacteria T Belongs to the adenylyl cyclase class-4 guanylyl cyclase family - - 4.6.1.1 ko:K01768 ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213 M00695 R00089,R00434 RC00295 ko00000,ko00001,ko00002,ko01000 - - - GAF_2,Guanylate_cyc,PAS_9,Response_reg k59_1631640_1 713587.THITH_04400 1.18e-88 280.0 COG0073@1|root,COG0143@1|root,COG0073@2|Bacteria,COG0143@2|Bacteria,1MUBY@1224|Proteobacteria,1RMYM@1236|Gammaproteobacteria,1WWU6@135613|Chromatiales 135613|Chromatiales J Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation metG - 6.1.1.10 ko:K01874 ko00450,ko00970,map00450,map00970 M00359,M00360 R03659,R04773 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,tRNA-synt_1g,tRNA_bind k59_730418_1 1410676.JNKL01000039_gene1508 2.1e-94 287.0 COG0330@1|root,COG0330@2|Bacteria,1MUM8@1224|Proteobacteria,1RNW8@1236|Gammaproteobacteria,1Y4E0@135624|Aeromonadales 135624|Aeromonadales O prohibitin homologues - - - - - - - - - - - - Band_7,Band_7_C k59_334946_1 1449076.JOOE01000002_gene764 8.4e-85 278.0 COG4774@1|root,COG4774@2|Bacteria,1NMCN@1224|Proteobacteria,2U44P@28211|Alphaproteobacteria,2KEAA@204457|Sphingomonadales 204457|Sphingomonadales P TonB dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_277355_1 1122137.AQXF01000002_gene479 9.15e-162 459.0 COG1960@1|root,COG1960@2|Bacteria,1MVJC@1224|Proteobacteria,2TUVB@28211|Alphaproteobacteria 28211|Alphaproteobacteria I acyl-CoA dehydrogenase MA20_22780 - 1.3.8.7 ko:K00249 ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320 M00013,M00036,M00087 R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754 RC00052,RC00068,RC00076,RC00095,RC00148,RC00246 ko00000,ko00001,ko00002,ko01000 - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_730424_2 262316.MAP_3125c 1.36e-37 140.0 COG0300@1|root,COG0300@2|Bacteria,2I4FN@201174|Actinobacteria,23F79@1762|Mycobacteriaceae 201174|Actinobacteria S Enoyl-(Acyl carrier protein) reductase - - - - - - - - - - - - adh_short k59_1631664_1 631362.Thi970DRAFT_02476 1.76e-128 379.0 COG0766@1|root,COG0766@2|Bacteria,1MUH7@1224|Proteobacteria,1RN91@1236|Gammaproteobacteria,1WXB6@135613|Chromatiales 135613|Chromatiales M Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine murA - 2.5.1.7 ko:K00790 ko00520,ko00550,ko01100,map00520,map00550,map01100 - R00660 RC00350 ko00000,ko00001,ko01000,ko01011 - - - EPSP_synthase k59_1631664_2 1123367.C666_07220 7.6e-08 50.4 COG5007@1|root,COG5007@2|Bacteria,1MZCZ@1224|Proteobacteria,2VU0K@28216|Betaproteobacteria,2KWVP@206389|Rhodocyclales 206389|Rhodocyclales K Belongs to the BolA IbaG family - - - - - - - - - - - - BolA k59_1631665_1 1304872.JAGC01000003_gene3270 1.68e-12 66.2 COG4420@1|root,COG4420@2|Bacteria,1RFFX@1224|Proteobacteria,437CY@68525|delta/epsilon subdivisions,2X2IU@28221|Deltaproteobacteria,2MEV9@213115|Desulfovibrionales 28221|Deltaproteobacteria S Protein of unknown function (DUF1003) - - - - - - - - - - - - DUF1003 k59_1631665_2 1151119.KB895501_gene2895 4.03e-29 108.0 COG0607@1|root,COG0607@2|Bacteria,2IKTC@201174|Actinobacteria,1WC6A@1268|Micrococcaceae 201174|Actinobacteria P Rhodanese Homology Domain - - - - - - - - - - - - Rhodanese k59_1120853_1 592026.GCWU0000282_002378 9.02e-37 132.0 COG0745@1|root,COG0745@2|Bacteria,1TPZ0@1239|Firmicutes,249IC@186801|Clostridia 186801|Clostridia T response regulator receiver srrA_2 - - - - - - - - - - - Response_reg,Trans_reg_C k59_1796245_1 296591.Bpro_2799 3.42e-55 179.0 COG0664@1|root,COG0664@2|Bacteria,1R64V@1224|Proteobacteria,2VJXN@28216|Betaproteobacteria,4ACEI@80864|Comamonadaceae 28216|Betaproteobacteria T Cyclic nucleotide-monophosphate binding domain - - - - - - - - - - - - cNMP_binding k59_1521243_1 1550073.JROH01000003_gene2409 9.46e-50 172.0 COG2271@1|root,COG2271@2|Bacteria,1P24P@1224|Proteobacteria,2URTW@28211|Alphaproteobacteria,2KECT@204457|Sphingomonadales 204457|Sphingomonadales G Sugar (and other) transporter - - - ko:K08195 - - - - ko00000,ko02000 2.A.1.15 - - MFS_1,MFS_4 k59_1120864_1 1229909.NSED_06260 8.76e-75 238.0 COG0119@1|root,arCOG02092@2157|Archaea,41SBX@651137|Thaumarchaeota 651137|Thaumarchaeota E Belongs to the alpha-IPM synthase homocitrate synthase family - - 2.3.3.13 ko:K01649 ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230 M00432 R01213 RC00004,RC00470,RC02754 br01601,ko00000,ko00001,ko00002,ko01000 - - - HMGL-like,LeuA_dimer k59_1120864_2 436308.Nmar_1069 1.24e-08 55.1 COG0473@1|root,arCOG01163@2157|Archaea,41SAA@651137|Thaumarchaeota 651137|Thaumarchaeota C Isocitrate isopropylmalate dehydrogenase - - 1.1.1.85 ko:K00052 ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230 M00432,M00535 R00994,R04426,R10052 RC00084,RC00417,RC03036 br01601,ko00000,ko00001,ko00002,ko01000 - - - Iso_dh k59_498298_1 1094980.Mpsy_1210 1.01e-42 145.0 COG2426@1|root,arCOG01330@2157|Archaea,2XZ2Y@28890|Euryarchaeota,2NAQX@224756|Methanomicrobia 224756|Methanomicrobia S Putative small multi-drug export protein - - - - - - - - - - - - Sm_multidrug_ex k59_498298_2 1408424.JHYI01000023_gene4200 0.000222 43.9 COG1164@1|root,COG1164@2|Bacteria,1U8XY@1239|Firmicutes,4HEV8@91061|Bacilli,1ZC0S@1386|Bacillus 91061|Bacilli E Peptidase M3A and M3B thimet oligopeptidase F - - - - - - - - - - - - Peptidase_M2,Peptidase_M3 k59_219309_1 1027273.GZ77_24945 2.45e-97 314.0 COG1629@1|root,COG4771@2|Bacteria,1MUC1@1224|Proteobacteria,1RRFS@1236|Gammaproteobacteria,1XJ3N@135619|Oceanospirillales 135619|Oceanospirillales P receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_277388_1 1500894.JQNN01000001_gene2732 3.4e-17 80.5 COG0726@1|root,COG0726@2|Bacteria,1RBMV@1224|Proteobacteria 1224|Proteobacteria G deacetylase - - - - - - - - - - - - Polysacc_deac_1 k59_277388_2 1121921.KB898707_gene1040 4.15e-45 155.0 COG2850@1|root,COG2850@2|Bacteria,1PJAE@1224|Proteobacteria,1SFQ1@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Cupin-like domain - - - - - - - - - - - - Cupin_8 k59_780577_1 316407.85674807 3.92e-175 501.0 COG0374@1|root,COG0374@2|Bacteria,1MWFJ@1224|Proteobacteria,1RMC3@1236|Gammaproteobacteria,3XP0G@561|Escherichia 1236|Gammaproteobacteria C Belongs to the NiFe NiFeSe hydrogenase large subunit family hyaB GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006113,GO:0008150,GO:0008152,GO:0009055,GO:0009061,GO:0009897,GO:0009986,GO:0009987,GO:0015980,GO:0016020,GO:0016151,GO:0016491,GO:0019897,GO:0019898,GO:0022900,GO:0030288,GO:0030313,GO:0031232,GO:0031236,GO:0031975,GO:0032991,GO:0042597,GO:0043167,GO:0043169,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0044569,GO:0045333,GO:0046872,GO:0046914,GO:0055114,GO:0071944,GO:0098552,GO:0098567,GO:1902494 1.12.5.1,1.12.99.6 ko:K05922,ko:K06281 ko00633,ko01120,map00633,map01120 - R08034 RC00250 ko00000,ko00001,ko01000 - - iSbBS512_1146.SbBS512_E2342,ic_1306.c3731 NiFeSe_Hases k59_1346390_1 1265310.CCBD010000037_gene2372 6.09e-17 80.1 COG2020@1|root,COG2020@2|Bacteria,2GN9N@201174|Actinobacteria,2336J@1762|Mycobacteriaceae 201174|Actinobacteria O NnrU protein - - 2.1.1.334 ko:K21310 ko00920,map00920 - R11546 RC02653 ko00000,ko00001,ko01000 - - - NnrU k59_1743903_1 497321.C664_15248 2.93e-67 224.0 COG0749@1|root,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,2VJ57@28216|Betaproteobacteria,2KUC6@206389|Rhodocyclales 206389|Rhodocyclales L In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity polA - 2.7.7.7 ko:K02335 ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032,ko03400 - - - 5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1 k59_1409095_1 395493.BegalDRAFT_1870 6.98e-41 151.0 COG0642@1|root,COG2205@2|Bacteria,1MXF8@1224|Proteobacteria,1RMMI@1236|Gammaproteobacteria,45ZTT@72273|Thiotrichales 72273|Thiotrichales T PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase - - 2.7.13.3 ko:K02668 ko02020,map02020 M00501 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 - - - HATPase_c,HisKA k59_617257_1 1449357.JQLK01000001_gene291 3.49e-67 216.0 COG0668@1|root,COG0668@2|Bacteria,1WJII@1297|Deinococcus-Thermus 1297|Deinococcus-Thermus M mechanosensitive ion channel - - - ko:K22044 - - - - ko00000,ko02000 1.A.23.3 - - MS_channel k59_617258_1 765913.ThidrDRAFT_0681 5.1e-15 79.0 COG2863@1|root,COG2863@2|Bacteria,1N7W9@1224|Proteobacteria,1S4KA@1236|Gammaproteobacteria,1WY97@135613|Chromatiales 135613|Chromatiales C PFAM Cytochrome C - - - - - - - - - - - - Cytochrom_C k59_730442_1 1120953.AUBH01000002_gene1427 1.88e-58 202.0 COG1629@1|root,COG4771@2|Bacteria,1MVFB@1224|Proteobacteria,1RNMS@1236|Gammaproteobacteria,463XN@72275|Alteromonadaceae 1236|Gammaproteobacteria P TonB dependent receptor - - - - - - - - - - - - Plug,TonB_dep_Rec k59_840159_2 553385.JEMF01000129_gene1989 1.29e-41 147.0 COG1131@1|root,COG1131@2|Bacteria,1MUW7@1224|Proteobacteria,1RMC5@1236|Gammaproteobacteria,1XHIF@135619|Oceanospirillales 135619|Oceanospirillales V (ABC) transporter - - - ko:K01990 - M00254 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_1459980_1 1279017.AQYJ01000021_gene2872 1.54e-97 295.0 COG0568@1|root,COG0568@2|Bacteria,1MUDI@1224|Proteobacteria,1RN8V@1236|Gammaproteobacteria,4641K@72275|Alteromonadaceae 1236|Gammaproteobacteria K COG0568 DNA-directed RNA polymerase, sigma subunit (sigma70 sigma32) rpoS GO:0000988,GO:0000990,GO:0001000,GO:0001121,GO:0001123,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006351,GO:0006352,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0016987,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0019899,GO:0031323,GO:0031326,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043175,GO:0043254,GO:0044087,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0070063,GO:0071704,GO:0080090,GO:0090304,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901576,GO:1903506,GO:2000112,GO:2000142,GO:2001141 - ko:K03087 ko02026,ko05111,map02026,map05111 - - - ko00000,ko00001,ko03021 - - - Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4 k59_1120908_1 387093.SUN_1594 2.1e-57 187.0 COG2326@1|root,COG2326@2|Bacteria,1MVE2@1224|Proteobacteria,42PA7@68525|delta/epsilon subdivisions,2YNSG@29547|Epsilonproteobacteria 29547|Epsilonproteobacteria S Polyphosphate kinase 2 (PPK2) - - 2.7.4.1 ko:K22468 ko00190,ko03018,map00190,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - PPK2 k59_1006817_1 1231391.AMZF01000037_gene588 1.24e-14 73.2 COG2141@1|root,COG2141@2|Bacteria,1MX64@1224|Proteobacteria,2VND1@28216|Betaproteobacteria 28216|Betaproteobacteria C Luciferase-like monooxygenase - - - - - - - - - - - - Bac_luciferase k59_1006817_2 1205680.CAKO01000010_gene3898 4.29e-19 87.0 COG0683@1|root,COG0683@2|Bacteria,1NHBN@1224|Proteobacteria,2TWTC@28211|Alphaproteobacteria,2JR5U@204441|Rhodospirillales 204441|Rhodospirillales E Periplasmic binding protein domain - - - - - - - - - - - - Peripla_BP_6 k59_730454_1 1122137.AQXF01000003_gene2399 1.42e-78 247.0 COG3746@1|root,COG3746@2|Bacteria,1RA39@1224|Proteobacteria,2U9KD@28211|Alphaproteobacteria 28211|Alphaproteobacteria P PFAM Phosphate-selective porin O and P - - - ko:K07221 - - - - ko00000,ko02000 1.B.5.1 - - Porin_O_P k59_1235532_1 1463885.KL578476_gene6661 7.53e-38 143.0 COG0337@1|root,COG0757@1|root,COG0337@2|Bacteria,COG0757@2|Bacteria,2GIUZ@201174|Actinobacteria 201174|Actinobacteria E Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) aroB GO:0003674,GO:0003824,GO:0003856,GO:0005488,GO:0005507,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0016020,GO:0016053,GO:0016829,GO:0016835,GO:0016838,GO:0019438,GO:0019752,GO:0030312,GO:0040007,GO:0043167,GO:0043169,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0046872,GO:0046914,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.1.71,4.2.3.4 ko:K01735,ko:K13829 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02412,R03083 RC00002,RC00078,RC00847 ko00000,ko00001,ko00002,ko01000 - - - DHQ_synthase,SKI k59_1409109_2 356851.JOAN01000006_gene373 5e-45 172.0 COG4695@1|root,COG4695@2|Bacteria,2HEYI@201174|Actinobacteria,4DGUS@85008|Micromonosporales 201174|Actinobacteria S Phage portal protein - - - - - - - - - - - - Phage_portal k59_840173_1 42256.RradSPS_1582 4.29e-11 65.1 COG0712@1|root,COG0712@2|Bacteria,2HNXP@201174|Actinobacteria,4CQ6B@84995|Rubrobacteria 84995|Rubrobacteria C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation atpH - - ko:K02113 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - OSCP k59_840173_2 246197.MXAN_7028 1.27e-15 76.3 COG0056@1|root,COG0056@2|Bacteria,1MUG7@1224|Proteobacteria,42MVX@68525|delta/epsilon subdivisions,2WIK7@28221|Deltaproteobacteria,2YUF7@29|Myxococcales 28221|Deltaproteobacteria F Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit atpA - 3.6.3.14 ko:K02111 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - - ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N k59_730461_1 1347342.BN863_4360 1.09e-81 246.0 28IG3@1|root,2Z8HM@2|Bacteria,4NFJR@976|Bacteroidetes,1HYV7@117743|Flavobacteriia 976|Bacteroidetes S Gliding motility protein GldL gldL - - - - - - - - - - - - k59_730461_2 1121889.AUDM01000001_gene147 8.31e-07 49.7 COG1262@1|root,COG1262@2|Bacteria,4NGY2@976|Bacteroidetes,1HXXN@117743|Flavobacteriia,2NSDC@237|Flavobacterium 976|Bacteroidetes S Gliding motility protein GldK gldK - - - - - - - - - - - FGE-sulfatase k59_840178_1 722419.PH505_ai00730 3.46e-73 228.0 COG0330@1|root,COG0330@2|Bacteria,1MX2I@1224|Proteobacteria,1RYZR@1236|Gammaproteobacteria,2Q2ND@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria O SPFH domain / Band 7 family - - - - - - - - - - - - Band_7 k59_392261_1 1229909.NSED_05675 6.36e-68 211.0 COG1846@1|root,arCOG03748@2157|Archaea,41T7R@651137|Thaumarchaeota 651137|Thaumarchaeota K DNA-binding transcription factor activity - - - - - - - - - - - - - k59_1235566_1 1340493.JNIF01000003_gene2382 1.06e-13 76.3 COG0577@1|root,COG0577@2|Bacteria 2|Bacteria V efflux transmembrane transporter activity - - - - - - - - - - - - FtsX,MacB_PCD k59_951212_1 118005.AWNK01000003_gene2203 6.15e-33 131.0 COG1449@1|root,COG1449@2|Bacteria 2|Bacteria G Belongs to the glycosyl hydrolase 57 family amyA GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464 2.4.1.25 ko:K22451 ko00500,map00500 - R05196 RC00049 ko00000,ko00001,ko01000 - GH57 - DUF1925,DUF1926,Glyco_hydro_57 k59_444084_1 748247.AZKH_1540 3.81e-50 175.0 COG0189@1|root,COG0189@2|Bacteria,1MX5X@1224|Proteobacteria,2VJP0@28216|Betaproteobacteria 28216|Betaproteobacteria HJ RimK-like ATPgrasp N-terminal domain - - - - - - - - - - - - RLAN,RimK k59_1698485_2 1123368.AUIS01000005_gene447 5.95e-19 87.0 COG0642@1|root,COG2205@2|Bacteria,1N58A@1224|Proteobacteria,1RP34@1236|Gammaproteobacteria,2NBSM@225057|Acidithiobacillales 225057|Acidithiobacillales T HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain - - 2.7.13.3 ko:K07711 ko02020,ko02024,map02020,map02024 M00502 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022 - - - HATPase_c,HisKA k59_229596_1 1265313.HRUBRA_01364 1.24e-101 305.0 COG1158@1|root,COG1158@2|Bacteria,1MUCF@1224|Proteobacteria,1RP95@1236|Gammaproteobacteria,1J4QP@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria K Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template rho GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006353,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097659,GO:1901360,GO:1901362,GO:1901363,GO:1901576 - ko:K03628 ko03018,map03018 - - - ko00000,ko00001,ko03019,ko03021 - - - ATP-synt_ab,Rho_N,Rho_RNA_bind k59_964146_1 1410676.JNKL01000013_gene1945 0.0003 47.4 COG1589@1|root,COG1589@2|Bacteria,1N0T7@1224|Proteobacteria,1S9FJ@1236|Gammaproteobacteria,1Y4EC@135624|Aeromonadales 135624|Aeromonadales D Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly ftsQ - - ko:K03589 ko04112,map04112 - - - ko00000,ko00001,ko03036 - - - FtsQ,POTRA_1 k59_964146_2 857087.Metme_0254 6.07e-05 44.3 COG0849@1|root,COG0849@2|Bacteria,1MUSR@1224|Proteobacteria,1RMXY@1236|Gammaproteobacteria,1XEK3@135618|Methylococcales 135618|Methylococcales D Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring ftsA - - ko:K03590 ko04112,map04112 - - - ko00000,ko00001,ko03036,ko04812 - - - FtsA,SHS2_FTSA k59_851304_1 1122137.AQXF01000002_gene332 9.58e-71 236.0 COG4421@1|root,COG4421@2|Bacteria,1R5RK@1224|Proteobacteria,2U181@28211|Alphaproteobacteria 28211|Alphaproteobacteria G COG4421 Capsular polysaccharide biosynthesis protein - - - - - - - - - - - - DUF563,Methyltransf_21 k59_1133574_1 767434.Fraau_2547 2.83e-55 188.0 COG0617@1|root,COG0617@2|Bacteria,1MVCS@1224|Proteobacteria,1RMBG@1236|Gammaproteobacteria,1X3TM@135614|Xanthomonadales 135614|Xanthomonadales H Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control pcnB - 2.7.7.19 ko:K00970 ko03018,map03018 - - - ko00000,ko00001,ko01000,ko03019 - - - PolyA_pol,PolyA_pol_RNAbd,PolyA_pol_arg_C k59_964147_1 1459636.NTE_01072 4.74e-68 218.0 COG0667@1|root,arCOG01617@2157|Archaea,41SXK@651137|Thaumarchaeota 651137|Thaumarchaeota C Aldo/keto reductase family - - - - - - - - - - - - Aldo_ket_red k59_1303253_1 270374.MELB17_01840 2.43e-77 237.0 COG2884@1|root,COG2884@2|Bacteria,1MVQ4@1224|Proteobacteria,1RMZA@1236|Gammaproteobacteria,464ZE@72275|Alteromonadaceae 1236|Gammaproteobacteria D ATPase involved in cell division ftsE GO:0000166,GO:0003674,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0008144,GO:0008150,GO:0009898,GO:0009987,GO:0016020,GO:0017076,GO:0019897,GO:0019898,GO:0030554,GO:0031234,GO:0032153,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042221,GO:0043167,GO:0043168,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0046677,GO:0050896,GO:0051301,GO:0071944,GO:0097159,GO:0097367,GO:0098552,GO:0098562,GO:1901265,GO:1901363 - ko:K09812 ko02010,map02010 M00256 - - ko00000,ko00001,ko00002,ko02000,ko03036 3.A.1.140 - - ABC_tran k59_1303253_2 1415778.JQMM01000001_gene489 7.59e-14 73.2 COG2177@1|root,COG2177@2|Bacteria,1MU65@1224|Proteobacteria,1RYBV@1236|Gammaproteobacteria,1J4H6@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria D Part of the ABC transporter FtsEX involved in cellular division ftsX GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0009274,GO:0009276,GO:0009987,GO:0016020,GO:0016021,GO:0030312,GO:0030313,GO:0031224,GO:0031975,GO:0032153,GO:0044425,GO:0044464,GO:0051301,GO:0071944 - ko:K09811 ko02010,map02010 M00256 - - ko00000,ko00001,ko00002,ko02000,ko03036 3.A.1.140 - - FtsX k59_1698494_1 1054860.KB913030_gene6340 1.82e-20 89.7 COG0697@1|root,COG0697@2|Bacteria,2I9UQ@201174|Actinobacteria 201174|Actinobacteria EG EamA-like transporter family - - - - - - - - - - - - EamA k59_60552_2 331869.BAL199_15293 1e-37 131.0 2A9WW@1|root,30Z4Z@2|Bacteria,1PM1G@1224|Proteobacteria,2UWN1@28211|Alphaproteobacteria,4BT5B@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria - - - - - - - - - - - - - - - k59_1472604_1 1089553.Tph_c21880 4.68e-53 183.0 COG0815@1|root,COG0815@2|Bacteria,1V095@1239|Firmicutes,24B2E@186801|Clostridia 186801|Clostridia M Carbon-nitrogen hydrolase - - - ko:K03820 - - - - ko00000,ko01000 - GT2 - CN_hydrolase k59_1415969_1 1131266.ARWQ01000002_gene468 2.68e-36 134.0 COG0129@1|root,arCOG04045@2157|Archaea,41SD0@651137|Thaumarchaeota 651137|Thaumarchaeota E Belongs to the IlvD Edd family ilvD - 4.2.1.9 ko:K01687 ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230 M00019,M00570 R01209,R04441,R05070 RC00468,RC01714 ko00000,ko00001,ko00002,ko01000 - - - ILVD_EDD k59_1415969_2 436308.Nmar_0885 5.31e-32 112.0 arCOG10558@1|root,arCOG10558@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_230646_2 1089552.KI911559_gene3537 1.41e-07 61.2 COG0628@1|root,COG0628@2|Bacteria,1MXXU@1224|Proteobacteria,2TVPN@28211|Alphaproteobacteria,2JRFY@204441|Rhodospirillales 204441|Rhodospirillales S AI-2E family transporter - - - - - - - - - - - - AI-2E_transport k59_965097_1 1089550.ATTH01000001_gene2120 3.02e-67 231.0 COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,4NEP3@976|Bacteroidetes,1FIWT@1100069|Bacteroidetes Order II. Incertae sedis 976|Bacteroidetes C Pyruvate:ferredoxin oxidoreductase core domain II porA - 1.2.7.11,1.2.7.3 ko:K00174 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - PFOR_II,POR,POR_N k59_965097_2 631362.Thi970DRAFT_01706 4.14e-57 191.0 COG1013@1|root,COG1013@2|Bacteria,1R5BF@1224|Proteobacteria,1RZ7Y@1236|Gammaproteobacteria,1WXDP@135613|Chromatiales 135613|Chromatiales C PFAM thiamine pyrophosphate enzyme - - 1.2.7.11,1.2.7.3 ko:K00175 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - TPP_enzyme_C k59_1416904_1 1122137.AQXF01000003_gene2157 1.56e-102 305.0 COG2255@1|root,COG2255@2|Bacteria,1MU38@1224|Proteobacteria,2TQNG@28211|Alphaproteobacteria 28211|Alphaproteobacteria L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing ruvB GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0050896,GO:0051716,GO:0071496 3.6.4.12 ko:K03551 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - RuvB_C,RuvB_N k59_739576_1 566466.NOR53_3097 2.21e-65 212.0 COG0334@1|root,COG0334@2|Bacteria,1MUMF@1224|Proteobacteria,1RPUZ@1236|Gammaproteobacteria,1J8WR@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria C Glutamate/Leucine/Phenylalanine/Valine dehydrogenase gdhA GO:0003674,GO:0003824,GO:0004353,GO:0004354,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016491,GO:0016638,GO:0016639,GO:0019752,GO:0042802,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.4.1.4 ko:K00262 ko00220,ko00250,ko00910,ko01100,map00220,map00250,map00910,map01100 - R00248 RC00006,RC02799 ko00000,ko00001,ko01000 - - iECH74115_1262.ECH74115_2481,iECSP_1301.ECSP_2329,iECs_1301.ECs2467,iG2583_1286.G2583_2207,iPC815.YPO3971,iSDY_1059.SDY_1514,iYL1228.KPN_01210,iZ_1308.Z2793 ELFV_dehydrog,ELFV_dehydrog_N k59_230647_1 1232683.ADIMK_0681 8.59e-57 192.0 COG0031@1|root,COG0031@2|Bacteria,1MUBE@1224|Proteobacteria,1RN6J@1236|Gammaproteobacteria,4641I@72275|Alteromonadaceae 1236|Gammaproteobacteria E Belongs to the cysteine synthase cystathionine beta- synthase family cysK - 2.5.1.47 ko:K01738 ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230 M00021 R00897,R03601,R04859 RC00020,RC02814,RC02821 ko00000,ko00001,ko00002,ko01000 - - - Glutaredoxin,PALP k59_344019_1 330214.NIDE0701 2.79e-55 181.0 COG0142@1|root,COG0142@2|Bacteria,3J0H1@40117|Nitrospirae 40117|Nitrospirae H Polyprenyl synthetase - - 2.5.1.1,2.5.1.10,2.5.1.29 ko:K13789 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00364,M00366 R01658,R02003,R02061 RC00279 ko00000,ko00001,ko00002,ko01000,ko01006 - - - polyprenyl_synt k59_1304170_1 1218076.BAYB01000029_gene4816 1.09e-74 243.0 COG0376@1|root,COG0376@2|Bacteria,1MUBF@1224|Proteobacteria,2VH5H@28216|Betaproteobacteria,1K3VG@119060|Burkholderiaceae 28216|Betaproteobacteria P Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity katG - 1.11.1.21 ko:K03782 ko00360,ko00380,ko00940,ko00983,ko01100,ko01110,map00360,map00380,map00940,map00983,map01100,map01110 - R00602,R00698,R02596,R02670,R03919,R04007,R07443,R11906 RC00034,RC00213,RC00767,RC02141 ko00000,ko00001,ko01000 - - - peroxidase k59_1755973_1 404589.Anae109_3678 1.64e-53 185.0 COG4372@1|root,COG4372@2|Bacteria,1MUCX@1224|Proteobacteria,43CJZ@68525|delta/epsilon subdivisions,2X7UE@28221|Deltaproteobacteria 28221|Deltaproteobacteria S IS66 C-terminal element - - - ko:K07484 - - - - ko00000 - - - DDE_Tnp_IS66,DDE_Tnp_IS66_C k59_908474_1 1121926.AXWO01000020_gene2022 3.15e-30 123.0 COG0046@1|root,COG0046@2|Bacteria,2GKG6@201174|Actinobacteria,4EY9G@85014|Glycomycetales 201174|Actinobacteria F AIR synthase related protein, C-terminal domain purL GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009987,GO:0018130,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 6.3.5.3 ko:K01952 ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130 M00048 R04463 RC00010,RC01160 ko00000,ko00001,ko00002,ko01000 - - - AIRS,AIRS_C k59_1643221_1 589865.DaAHT2_2095 1.63e-88 269.0 COG0057@1|root,COG0057@2|Bacteria,1MU93@1224|Proteobacteria,42N9Q@68525|delta/epsilon subdivisions,2WIK1@28221|Deltaproteobacteria,2MIIT@213118|Desulfobacterales 28221|Deltaproteobacteria G Belongs to the glyceraldehyde-3-phosphate dehydrogenase family gap - 1.2.1.12 ko:K00134 ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01061 RC00149 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - Gp_dh_C,Gp_dh_N k59_344020_1 866536.Belba_2722 7.62e-71 231.0 COG3666@1|root,COG3666@2|Bacteria,4NEDD@976|Bacteroidetes,47NCX@768503|Cytophagia 976|Bacteroidetes L PFAM Transposase DDE domain - - - - - - - - - - - - DDE_Tnp_1_6,DUF772 k59_400279_1 1122137.AQXF01000003_gene2166 5.77e-46 156.0 COG0834@1|root,COG0834@2|Bacteria,1RH2S@1224|Proteobacteria,2UHC7@28211|Alphaproteobacteria 28211|Alphaproteobacteria ET ABC-type amino acid transport signal transduction systems periplasmic component domain - - - ko:K02030 - M00236 - - ko00000,ko00002,ko02000 3.A.1.3 - - SBP_bac_3 k59_852293_1 1122137.AQXF01000006_gene972 7.21e-143 407.0 COG0090@1|root,COG0090@2|Bacteria,1MVTD@1224|Proteobacteria,2TTKD@28211|Alphaproteobacteria 28211|Alphaproteobacteria J One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity rplB GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02886 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L2,Ribosomal_L2_C k59_852293_2 1122137.AQXF01000006_gene971 3.06e-60 185.0 COG0185@1|root,COG0185@2|Bacteria,1RGYX@1224|Proteobacteria,2U95S@28211|Alphaproteobacteria 28211|Alphaproteobacteria J Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA rpsS GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015935,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042274,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904 - ko:K02965 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S19 k59_852293_3 1122137.AQXF01000006_gene970 1.51e-60 188.0 COG0091@1|root,COG0091@2|Bacteria,1RH0W@1224|Proteobacteria,2U96X@28211|Alphaproteobacteria 28211|Alphaproteobacteria J The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome rplV GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904 - ko:K02890 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L22 k59_852293_4 1122137.AQXF01000006_gene969 3.6e-46 154.0 COG0092@1|root,COG0092@2|Bacteria,1MUAI@1224|Proteobacteria,2TRZ2@28211|Alphaproteobacteria 28211|Alphaproteobacteria J Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation rpsC GO:0002181,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904 - ko:K02982 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - KH_2,Ribosomal_S3_C k59_1473707_1 1123368.AUIS01000003_gene1765 1.21e-44 165.0 COG1450@1|root,COG1450@2|Bacteria,1MUUA@1224|Proteobacteria,1RPJS@1236|Gammaproteobacteria 1236|Gammaproteobacteria NU General Secretion Pathway protein xcsD - - ko:K02453 ko03070,ko05111,map03070,map05111 M00331 - - ko00000,ko00001,ko00002,ko02044 3.A.15 - - Secretin,Secretin_N k59_569740_1 697282.Mettu_0204 1.77e-40 164.0 COG3209@1|root,COG3209@2|Bacteria,1MVV1@1224|Proteobacteria,1RP75@1236|Gammaproteobacteria,1XGAS@135618|Methylococcales 1236|Gammaproteobacteria M TIGRFAM RHS repeat-associated core domain - - - - - - - - - - - - DUF11,RHS,RHS_repeat k59_174480_1 977880.RALTA_A3016 9.47e-27 109.0 COG0737@1|root,COG0737@2|Bacteria,1MX03@1224|Proteobacteria,2VJTS@28216|Betaproteobacteria,1K2Y9@119060|Burkholderiaceae 28216|Betaproteobacteria F Belongs to the 5'-nucleotidase family - - 3.1.3.5,3.6.1.45 ko:K11751,ko:K17224 ko00230,ko00240,ko00760,ko00920,ko01100,ko01110,ko01120,map00230,map00240,map00760,map00920,map01100,map01110,map01120 M00595 R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346,R10151 RC00017,RC03151,RC03152 ko00000,ko00001,ko00002,ko01000 - - - 5_nucleotid_C k59_682535_1 69293.ENSGACP00000018223 1.53e-19 92.8 COG1022@1|root,KOG1256@2759|Eukaryota,39DMK@33154|Opisthokonta,3BB7F@33208|Metazoa,3CY7N@33213|Bilateria,48A6X@7711|Chordata,499E4@7742|Vertebrata,49R48@7898|Actinopterygii 33208|Metazoa I long-chain-fatty-acid--CoA ligase ACSBG2-like bgm GO:0001676,GO:0003674,GO:0003824,GO:0004467,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0006950,GO:0007498,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009888,GO:0009987,GO:0015645,GO:0016053,GO:0016405,GO:0016874,GO:0016877,GO:0016878,GO:0019725,GO:0019752,GO:0032502,GO:0032787,GO:0033554,GO:0034976,GO:0042592,GO:0042749,GO:0042752,GO:0042753,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0045187,GO:0045938,GO:0046394,GO:0048518,GO:0048520,GO:0048856,GO:0048878,GO:0050789,GO:0050795,GO:0050896,GO:0051239,GO:0051240,GO:0051716,GO:0055088,GO:0055090,GO:0060249,GO:0065007,GO:0065008,GO:0070050,GO:0070328,GO:0071704,GO:0072330,GO:1901576 3.4.19.3,6.2.1.3 ko:K01304,ko:K15013 ko00061,ko00071,ko01100,ko01212,ko03320,ko04920,map00061,map00071,map01100,map01212,map03320,map04920 M00086 R01280 RC00004,RC00014 ko00000,ko00001,ko00002,ko01000,ko01002,ko01004 - - - AMP-binding k59_852307_1 314285.KT71_15259 1.39e-48 174.0 COG1231@1|root,COG1231@2|Bacteria,1QXX6@1224|Proteobacteria,1T3IZ@1236|Gammaproteobacteria,1J5KT@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E K COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit - - 1.5.99.6 ko:K00316 ko00330,ko00410,ko01100,map00330,map00410,map01100 - R01914,R01915 RC00053,RC00225 ko00000,ko00001,ko01000 - - - NAD_binding_8 k59_344032_1 247634.GPB2148_1979 6.08e-125 363.0 COG0320@1|root,COG0320@2|Bacteria,1MVRD@1224|Proteobacteria,1RMAT@1236|Gammaproteobacteria 1236|Gammaproteobacteria H Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives lipA - 2.8.1.8 ko:K03644 ko00785,ko01100,map00785,map01100 - R07767,R07768 RC01978 ko00000,ko00001,ko01000 - - - LIAS_N,Radical_SAM k59_4785_1 1430440.MGMSRv2_3789 2.6e-31 119.0 COG4974@1|root,COG4974@2|Bacteria,1MVAN@1224|Proteobacteria,2TTXT@28211|Alphaproteobacteria,2JSFC@204441|Rhodospirillales 204441|Rhodospirillales L Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - - - - - - - - - - Phage_int_SAM_4,Phage_integrase k59_795849_1 342451.SSP2407 1.45e-62 209.0 COG0155@1|root,COG0155@2|Bacteria,1TS58@1239|Firmicutes,4HBEX@91061|Bacilli,4GXCM@90964|Staphylococcaceae 91061|Bacilli H Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate cysI GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0006790,GO:0008150,GO:0008152,GO:0009337,GO:0009987,GO:0016002,GO:0016491,GO:0016667,GO:0016673,GO:0019419,GO:0032991,GO:0044237,GO:0044424,GO:0044464,GO:0050311,GO:0055114 1.8.1.2,1.8.7.1 ko:K00381,ko:K00392 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00176 R00858,R00859,R03600 RC00065 ko00000,ko00001,ko00002,ko01000 - - - NIR_SIR,NIR_SIR_ferr k59_795849_2 575788.VS_0299 5.48e-45 162.0 COG0369@1|root,COG0369@2|Bacteria,1QUAH@1224|Proteobacteria,1T1RJ@1236|Gammaproteobacteria,1XT6J@135623|Vibrionales 135623|Vibrionales P Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component cysJ - 1.8.1.2 ko:K00380 ko00920,ko01100,ko01120,map00920,map01100,map01120 M00176 R00858 RC00065 ko00000,ko00001,ko00002,ko01000 - - - FAD_binding_1,Flavodoxin_1,NAD_binding_1 k59_230671_1 1122137.AQXF01000004_gene1608 8.97e-149 423.0 COG0500@1|root,COG2226@2|Bacteria,1MX8I@1224|Proteobacteria,2TRWR@28211|Alphaproteobacteria 28211|Alphaproteobacteria H Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2- polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) ubiE - 2.1.1.163,2.1.1.201 ko:K03183 ko00130,ko01100,ko01110,map00130,map01100,map01110 M00116,M00117 R04990,R04993,R06859,R08774,R09736 RC00003,RC01253,RC01662 ko00000,ko00001,ko00002,ko01000 - - - Ubie_methyltran k59_230671_2 1122137.AQXF01000004_gene1609 5.85e-151 439.0 COG0661@1|root,COG0661@2|Bacteria,1MU1Z@1224|Proteobacteria,2TS87@28211|Alphaproteobacteria 28211|Alphaproteobacteria S Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis ubiB - - ko:K03688 - - - - ko00000 - - - ABC1 k59_795852_2 1385511.N783_09795 6.74e-16 81.3 COG2204@1|root,COG2204@2|Bacteria,1VSKG@1239|Firmicutes,4HCST@91061|Bacilli 91061|Bacilli T response regulator - - - ko:K07714 ko02020,map02020 M00500 - - ko00000,ko00001,ko00002,ko02022 - - - HTH_8,Response_reg,Sigma54_activat k59_569743_1 436308.Nmar_0079 3.43e-102 309.0 COG1797@1|root,arCOG00106@2157|Archaea,41SBP@651137|Thaumarchaeota 651137|Thaumarchaeota H Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source cbiA - 6.3.5.11,6.3.5.9 ko:K02224 ko00860,ko01100,ko01120,map00860,map01100,map01120 - R05224,R05815 RC00010,RC01301 ko00000,ko00001,ko01000 - - - CbiA,GATase_3 k59_569743_3 1229909.NSED_00080 6.57e-142 405.0 COG1093@1|root,arCOG04107@2157|Archaea,41SHY@651137|Thaumarchaeota 651137|Thaumarchaeota J Translation initiation factor 2, alpha subunit - - - ko:K03237 ko03013,ko04138,ko04140,ko04141,ko04210,ko04932,ko05160,ko05162,ko05164,ko05168,map03013,map04138,map04140,map04141,map04210,map04932,map05160,map05162,map05164,map05168 - - - ko00000,ko00001,ko03012 - - - EIF_2_alpha,S1 k59_1022135_1 1123053.AUDG01000012_gene1679 4.74e-07 51.6 COG2067@1|root,COG2067@2|Bacteria,1PXPC@1224|Proteobacteria,1RQKS@1236|Gammaproteobacteria 1236|Gammaproteobacteria I Protein of unknown function (DUF3570) - - - - - - - - - - - - DUF3570 k59_1022135_2 203122.Sde_3552 1.18e-29 107.0 2E3QA@1|root,32YN8@2|Bacteria,1N98P@1224|Proteobacteria,1SCNQ@1236|Gammaproteobacteria,468BH@72275|Alteromonadaceae 1236|Gammaproteobacteria S Domain of unknown function (DUF4266) - - - - - - - - - - - - DUF4266 k59_1022135_3 236097.ADG881_3286 4.75e-24 97.1 COG3637@1|root,COG3637@2|Bacteria,1RDPZ@1224|Proteobacteria,1S4GQ@1236|Gammaproteobacteria,1XP8B@135619|Oceanospirillales 135619|Oceanospirillales M Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety - - - - - - - - - - - - OMP_b-brl k59_1699572_1 1229909.NSED_02415 5.28e-39 135.0 COG1392@1|root,arCOG02640@2157|Archaea,41SKJ@651137|Thaumarchaeota 651137|Thaumarchaeota P Protein of unknown function DUF47 - - - ko:K07220 - - - - ko00000 - - - PhoU_div k59_1699572_2 436308.Nmar_0484 7.24e-125 358.0 COG0704@1|root,arCOG00232@2157|Archaea,41T42@651137|Thaumarchaeota 651137|Thaumarchaeota P PhoU domain - - - ko:K02039 - - - - ko00000 - - - PhoU k59_1699572_3 436308.Nmar_0483 3.42e-38 134.0 COG1117@1|root,arCOG00231@2157|Archaea,41SYJ@651137|Thaumarchaeota 651137|Thaumarchaeota P Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system pstB - 3.6.3.27 ko:K02036 ko02010,map02010 M00222 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.7 - - ABC_tran k59_1022140_1 1027273.GZ77_13145 9.33e-11 62.4 COG1028@1|root,COG1028@2|Bacteria,1QDWF@1224|Proteobacteria,1RR7J@1236|Gammaproteobacteria,1XR42@135619|Oceanospirillales 135619|Oceanospirillales IQ KR domain - - - - - - - - - - - - adh_short_C2 k59_1022140_2 1535422.ND16A_0591 7.03e-178 503.0 COG0119@1|root,COG0119@2|Bacteria,1MVQG@1224|Proteobacteria,1RPPW@1236|Gammaproteobacteria 1236|Gammaproteobacteria E Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of aromatic compounds mhpE GO:0003674,GO:0003824,GO:0008701,GO:0016829,GO:0016830,GO:0016833 2.3.3.13,4.1.3.39 ko:K01649,ko:K01666 ko00290,ko00360,ko00362,ko00620,ko00621,ko00622,ko01100,ko01110,ko01120,ko01210,ko01220,ko01230,map00290,map00360,map00362,map00620,map00621,map00622,map01100,map01110,map01120,map01210,map01220,map01230 M00432,M00545,M00569 R00750,R01213 RC00004,RC00307,RC00371,RC00470,RC02754 br01601,br01602,ko00000,ko00001,ko00002,ko01000 - - iECIAI39_1322.ECIAI39_0326,iEcSMS35_1347.EcSMS35_0383,iYL1228.KPN_02117 DmpG_comm,HMGL-like k59_1473721_1 1229909.NSED_08325 1.39e-104 315.0 COG0644@1|root,arCOG00570@2157|Archaea,41SBB@651137|Thaumarchaeota 651137|Thaumarchaeota C Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains - - - - - - - - - - - - - k59_1473721_2 436308.Nmar_1513 3.2e-34 122.0 COG1325@1|root,arCOG01042@2157|Archaea,41SWK@651137|Thaumarchaeota 651137|Thaumarchaeota J RNA binding - - - ko:K07581 - - - - ko00000 - - - RNA_binding k59_1586399_1 756272.Plabr_2624 4.53e-06 54.7 COG0793@1|root,COG0793@2|Bacteria 2|Bacteria M Belongs to the peptidase S41A family prc - 3.4.21.102 ko:K03797 - - - - ko00000,ko01000,ko01002 - - - PDZ,PDZ_2,Peptidase_S41 k59_1586401_1 1096930.L284_02095 4.88e-22 89.7 COG0632@1|root,COG0632@2|Bacteria,1MWJR@1224|Proteobacteria,2TSKM@28211|Alphaproteobacteria,2K2JA@204457|Sphingomonadales 204457|Sphingomonadales L The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB ruvA - 3.6.4.12 ko:K03550 ko03440,map03440 - - - ko00000,ko00001,ko01000,ko03400 - - - HHH_5,RuvA_C,RuvA_N k59_1586401_2 1144305.PMI02_02483 1.5e-16 80.9 COG1807@1|root,COG1807@2|Bacteria,1NAG4@1224|Proteobacteria,2URE0@28211|Alphaproteobacteria,2KA2S@204457|Sphingomonadales 204457|Sphingomonadales M Alg9-like mannosyltransferase family - - - - - - - - - - - - Glyco_transf_22 k59_1473726_1 498211.CJA_2170 1.97e-44 162.0 COG0308@1|root,COG0308@2|Bacteria,1MUCI@1224|Proteobacteria,1RMA7@1236|Gammaproteobacteria,1FGPJ@10|Cellvibrio 1236|Gammaproteobacteria E Domain of unknown function (DUF3458_C) ARM repeats pepN GO:0003674,GO:0003824,GO:0004177,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006508,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008235,GO:0008237,GO:0008238,GO:0008270,GO:0009056,GO:0009987,GO:0016020,GO:0016787,GO:0019538,GO:0033218,GO:0034641,GO:0042277,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0043171,GO:0043603,GO:0044237,GO:0044238,GO:0044248,GO:0044424,GO:0044464,GO:0046872,GO:0046914,GO:0070006,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901565,GO:1901575 3.4.11.2 ko:K01256 ko00480,ko01100,map00480,map01100 - R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 - - iECIAI1_1343.ECIAI1_0973,iECO103_1326.ECO103_0977,iECP_1309.ECP_0944,iECSE_1348.ECSE_0993,iECW_1372.ECW_m1042,iEKO11_1354.EKO11_2898,iWFL_1372.ECW_m1042 DUF3458,DUF3458_C,Peptidase_M1 k59_513092_1 1205680.CAKO01000040_gene808 1.37e-43 149.0 2AY4N@1|root,31Q6J@2|Bacteria 2|Bacteria - - - - - - - - - - - - - - - k59_1756031_1 158500.BV97_03803 2.74e-79 242.0 COG1802@1|root,COG1802@2|Bacteria,1P2DT@1224|Proteobacteria,2TSI4@28211|Alphaproteobacteria,2K6YI@204457|Sphingomonadales 204457|Sphingomonadales K FCD - - - - - - - - - - - - FCD,GntR k59_117965_1 1134474.O59_001172 3.72e-125 375.0 COG0366@1|root,COG0366@2|Bacteria,1MVKX@1224|Proteobacteria,1RMXP@1236|Gammaproteobacteria 1236|Gammaproteobacteria G Alpha amylase catalytic ams - 2.4.1.4,3.2.1.1,5.4.99.16 ko:K05341,ko:K05343 ko00500,ko01100,map00500,map01100 - R01557,R01823,R02108,R02112,R11262 RC00028,RC01816 ko00000,ko00001,ko01000 - GH13 - Alpha-amylase,Malt_amylase_C k59_682562_1 187272.Mlg_1703 1.99e-17 83.2 COG0715@1|root,COG0715@2|Bacteria,1MWDN@1224|Proteobacteria,1RPUP@1236|Gammaproteobacteria,1X036@135613|Chromatiales 135613|Chromatiales P NMT1-like family - - - ko:K15576 ko00910,ko02010,map00910,map02010 M00438 - - ko00000,ko00001,ko00002,ko02000 3.A.1.16.1,3.A.1.16.2 - - NMT1_2 k59_682562_2 1499686.BN1079_02562 5.75e-143 412.0 COG0408@1|root,COG0408@2|Bacteria,1MWMF@1224|Proteobacteria,1RMM8@1236|Gammaproteobacteria 1236|Gammaproteobacteria H Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX hemF GO:0003674,GO:0003824,GO:0004109,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016491,GO:0016627,GO:0016634,GO:0018130,GO:0019438,GO:0030145,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0046872,GO:0046906,GO:0046914,GO:0046983,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576 1.3.3.3 ko:K00228 ko00860,ko01100,ko01110,map00860,map01100,map01110 M00121 R03220 RC00884 ko00000,ko00001,ko00002,ko01000 - - iAF1260.b2436,iBWG_1329.BWG_2198,iECDH10B_1368.ECDH10B_2601,iECDH1ME8569_1439.ECDH1ME8569_2370,iETEC_1333.ETEC_2549,iEcDH1_1363.EcDH1_1225,iEcHS_1320.EcHS_A2573,iEcolC_1368.EcolC_1243,iJO1366.b2436,iJR904.b2436,iY75_1357.Y75_RS12760 Coprogen_oxidas k59_682562_3 859657.RPSI07_mp0260 2.89e-21 96.3 COG2199@1|root,COG2200@1|root,COG2199@2|Bacteria,COG2200@2|Bacteria,1MVJY@1224|Proteobacteria,2VI53@28216|Betaproteobacteria,1K1FA@119060|Burkholderiaceae 28216|Betaproteobacteria T GGDEF domain containing protein yjcC - - - - - - - - - - - CBS,EAL,GGDEF k59_1530113_1 292459.STH7 1.11e-155 466.0 COG0188@1|root,COG0188@2|Bacteria,1TP2Z@1239|Firmicutes,2482G@186801|Clostridia 186801|Clostridia L A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner gyrA - 5.99.1.3 ko:K02469 - - - - ko00000,ko01000,ko03032,ko03400 - - - DNA_gyraseA_C,DNA_topoisoIV k59_1360679_1 247634.GPB2148_612 3.35e-124 368.0 COG0615@1|root,COG2870@1|root,COG0615@2|Bacteria,COG2870@2|Bacteria,1MV3Z@1224|Proteobacteria,1RMAJ@1236|Gammaproteobacteria,1J4II@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria H Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose hldE GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0006629,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008219,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009311,GO:0009312,GO:0009987,GO:0012501,GO:0016051,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016779,GO:0019200,GO:0033692,GO:0033785,GO:0033786,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0046401,GO:0046835,GO:0070566,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509 2.7.1.167,2.7.7.70 ko:K03272,ko:K21344 ko00540,ko01100,map00540,map01100 M00064 R05644,R05646 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000,ko01005 - - iECH74115_1262.ECH74115_4363,iECSP_1301.ECSP_4025,iECs_1301.ECs3935,iPC815.YPO0654,iZ_1308.Z4405 CTP_transf_like,PfkB k59_1699589_1 158500.BV97_00271 4.19e-17 79.0 COG1024@1|root,COG1024@2|Bacteria,1MVQN@1224|Proteobacteria,2TUXD@28211|Alphaproteobacteria,2KA4E@204457|Sphingomonadales 204457|Sphingomonadales I Enoyl-CoA hydratase/isomerase - - 5.3.3.18 ko:K15866 ko00360,ko01120,map00360,map01120 - R09837,R09839 RC00004,RC00326,RC02689,RC03003 ko00000,ko00001,ko01000 - - - ECH_1 k59_1699589_2 1144305.PMI02_01761 4.35e-64 204.0 COG2070@1|root,COG2070@2|Bacteria,1MWPC@1224|Proteobacteria,2TQRT@28211|Alphaproteobacteria,2K1CK@204457|Sphingomonadales 204457|Sphingomonadales S 2-nitropropane dioxygenase - - 1.13.12.16 ko:K00459 ko00910,map00910 - R00025 RC02541,RC02759 ko00000,ko00001,ko01000 - - - NMO k59_1530115_1 756272.Plabr_1954 1.11e-87 263.0 COG3335@1|root,COG3335@2|Bacteria,2IZX0@203682|Planctomycetes 203682|Planctomycetes L DDE superfamily endonuclease - - - - - - - - - - - - DDE_3 k59_682566_1 107636.JQNK01000004_gene851 4.59e-69 234.0 COG3119@1|root,COG3119@2|Bacteria,1MV92@1224|Proteobacteria,2TTXG@28211|Alphaproteobacteria,36ZG2@31993|Methylocystaceae 28211|Alphaproteobacteria P Sulfatase - - 3.1.6.1 ko:K01130 ko00140,ko00600,map00140,map00600 - R03980,R04856 RC00128,RC00231 ko00000,ko00001,ko01000 - - - Sulfatase k59_1134714_1 1122137.AQXF01000006_gene747 5.47e-63 206.0 COG0665@1|root,COG0665@2|Bacteria,1MVGP@1224|Proteobacteria,2TRX9@28211|Alphaproteobacteria 28211|Alphaproteobacteria E oxidoreductase puuB - - ko:K09471 ko00330,ko01100,map00330,map01100 M00136 R07415 RC00062 ko00000,ko00001,ko00002,ko01000 - - - DAO k59_908524_2 155864.EDL933_2991 1.04e-36 128.0 COG3637@1|root,COG3637@2|Bacteria,1RH8M@1224|Proteobacteria,1SE1S@1236|Gammaproteobacteria 1224|Proteobacteria M Corresponds to locus_tag lomP - - ko:K07804 ko02020,map02020 - - - ko00000,ko00001 - - - Ail_Lom,OMP_b-brl k59_1756046_1 1122951.ATUE01000012_gene521 1.93e-96 301.0 COG0480@1|root,COG0480@2|Bacteria,1MUCV@1224|Proteobacteria,1RNSZ@1236|Gammaproteobacteria,3NIEG@468|Moraxellaceae 1236|Gammaproteobacteria J Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome fusA - - ko:K02355 - - - - ko00000,ko03012,ko03029 - - - EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2 k59_626143_1 706587.Desti_5134 1.3e-50 183.0 COG0515@1|root,COG0642@1|root,COG0784@1|root,COG2198@1|root,COG3899@1|root,COG0515@2|Bacteria,COG0784@2|Bacteria,COG2198@2|Bacteria,COG2205@2|Bacteria,COG3899@2|Bacteria,1NRP8@1224|Proteobacteria,42M0Y@68525|delta/epsilon subdivisions,2X7MY@28221|Deltaproteobacteria 28221|Deltaproteobacteria T Histidine kinase A domain protein - - - - - - - - - - - - AAA_16,GAF,GAF_2,HAMP,HATPase_c,HisKA,Pkinase,Response_reg k59_1473744_1 314231.FP2506_18594 2.7e-50 184.0 COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,2TQPZ@28211|Alphaproteobacteria,2PJBF@255475|Aurantimonadaceae 28211|Alphaproteobacteria O Trypsin degP GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005575,GO:0005623,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0016787,GO:0017171,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043170,GO:0044238,GO:0044464,GO:0070011,GO:0071704,GO:0140096,GO:1901564 3.4.21.107 ko:K04771 ko01503,ko02020,map01503,map02020 M00728 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 - - - PDZ,PDZ_2,Trypsin_2 k59_1473744_2 1121451.DESAM_20395 3.25e-07 54.3 COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,42N89@68525|delta/epsilon subdivisions,2WIUT@28221|Deltaproteobacteria,2M7ZS@213115|Desulfovibrionales 28221|Deltaproteobacteria M PDZ DHR GLGF domain protein - - 3.4.21.107 ko:K04771 ko01503,ko02020,map01503,map02020 M00728 - - ko00000,ko00001,ko00002,ko01000,ko01002,ko03110 - - - PDZ_2,Trypsin_2 k59_4853_1 483219.LILAB_29005 1.9e-14 78.2 COG1572@1|root,COG1572@2|Bacteria,1RC2V@1224|Proteobacteria,43BYC@68525|delta/epsilon subdivisions,2X79A@28221|Deltaproteobacteria,2YVA4@29|Myxococcales 28221|Deltaproteobacteria NU bacterial-type flagellum-dependent cell motility - - - - - - - - - - - - - k59_61633_1 1137799.GZ78_26100 2.12e-64 214.0 COG0591@1|root,COG0591@2|Bacteria,1MUBI@1224|Proteobacteria,1T3SF@1236|Gammaproteobacteria,1XP4Q@135619|Oceanospirillales 135619|Oceanospirillales E Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family - - - - - - - - - - - - SSF k59_1756059_1 1046627.BZARG_1209 3.62e-83 262.0 COG0038@1|root,COG0517@1|root,COG0038@2|Bacteria,COG0517@2|Bacteria,4NFCF@976|Bacteroidetes,1HWJE@117743|Flavobacteriia 976|Bacteroidetes P Chloride channel protein - - - ko:K03281 - - - - ko00000 2.A.49 - - CBS,Voltage_CLC k59_1146969_1 876044.IMCC3088_676 3.36e-92 300.0 COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,1MU7B@1224|Proteobacteria,1RN2W@1236|Gammaproteobacteria,1J55M@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E Glutamate synthase domain gltB GO:0003674,GO:0003824,GO:0004355,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006541,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0015930,GO:0016053,GO:0016491,GO:0016638,GO:0016639,GO:0019676,GO:0019740,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045181,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 1.4.1.13,1.4.1.14 ko:K00265 ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230 - R00093,R00114,R00248 RC00006,RC00010,RC02799 ko00000,ko00001,ko01000 - - iBWG_1329.BWG_2914,iECDH10B_1368.ECDH10B_3387,iECDH1ME8569_1439.EcDH1_0495,iEcDH1_1363.EcDH1_0495,iPC815.YPO3557 GATase_2,GXGXG,Glu_syn_central,Glu_synthase k59_525021_1 1122137.AQXF01000006_gene672 1.12e-39 150.0 COG0308@1|root,COG0308@2|Bacteria,1MUCI@1224|Proteobacteria,2TRUM@28211|Alphaproteobacteria 28211|Alphaproteobacteria E aminopeptidase N pepN GO:0003674,GO:0003824,GO:0004177,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008235,GO:0008237,GO:0008238,GO:0008270,GO:0016020,GO:0016787,GO:0019538,GO:0033218,GO:0042277,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0044238,GO:0044424,GO:0044464,GO:0046872,GO:0046914,GO:0070006,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564 3.4.11.2 ko:K01256 ko00480,ko01100,map00480,map01100 - R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 - - - DUF3458,DUF3458_C,Peptidase_M1 k59_1090389_1 438753.AZC_4419 8.1e-09 62.4 COG2242@1|root,COG2242@2|Bacteria,1QVKC@1224|Proteobacteria,2TWH7@28211|Alphaproteobacteria,3EZ5F@335928|Xanthobacteraceae 28211|Alphaproteobacteria H Methyltransferase FkbM domain MA20_43520 - - - - - - - - - - - Methyltransf_21 k59_74644_1 316067.Geob_0837 2.76e-184 531.0 COG4799@1|root,COG4799@2|Bacteria,1MVAX@1224|Proteobacteria,43AEE@68525|delta/epsilon subdivisions,2WIRF@28221|Deltaproteobacteria 28221|Deltaproteobacteria I PFAM carboxyl transferase - - - - - - - - - - - - Carboxyl_trans k59_74644_2 653733.Selin_2361 4.17e-63 218.0 COG0439@1|root,COG0511@1|root,COG0439@2|Bacteria,COG0511@2|Bacteria 2|Bacteria I ligase activity, forming carbon-carbon bonds accB - 2.3.1.12,2.3.1.39,4.1.1.3,6.3.4.14,6.4.1.2 ko:K00627,ko:K00645,ko:K01572,ko:K01961,ko:K02160 ko00010,ko00020,ko00061,ko00333,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00010,map00020,map00061,map00333,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212 M00082,M00307,M00376 R00209,R00217,R00742,R01626,R02569,R04385,R11671 RC00004,RC00039,RC00040,RC00253,RC00367,RC02727,RC02742,RC02857 br01601,ko00000,ko00001,ko00002,ko01000,ko01004,ko02000 3.B.1.1.1 - - Acyl_transf_1,Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2 k59_469056_1 1122603.ATVI01000001_gene1853 4.8e-30 124.0 COG0642@1|root,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,1SKTW@1236|Gammaproteobacteria,1XD8T@135614|Xanthomonadales 135614|Xanthomonadales T Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain) - - - - - - - - - - - - HATPase_c,HisKA,Hpt,PAS_3,Response_reg k59_1373686_1 316407.85676806 3.55e-121 354.0 COG1448@1|root,COG1448@2|Bacteria,1MUT0@1224|Proteobacteria,1RN02@1236|Gammaproteobacteria,3XMH8@561|Escherichia 1236|Gammaproteobacteria E Broad-specificity enzyme that catalyzes the transamination of 2-ketoisocaproate, p-hydroxyphenylpyruvate, and phenylpyruvate to yield leucine, tyrosine, and phenylalanine, respectively. In vitro, is able to catalyze the conversion of beta-methyl phenylpyruvate to the nonproteinogenic amino acid (2S,3S)-beta-methyl-phenylalanine, a building block of the antibiotic mannopeptimycin produced by Streptomyces hygroscopicus NRRL3085 tyrB GO:0003674,GO:0003824,GO:0004838,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006531,GO:0006532,GO:0006551,GO:0006558,GO:0006570,GO:0006571,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0008793,GO:0009058,GO:0009066,GO:0009067,GO:0009072,GO:0009073,GO:0009081,GO:0009082,GO:0009094,GO:0009095,GO:0009098,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0017144,GO:0019292,GO:0019438,GO:0019752,GO:0019842,GO:0030170,GO:0033585,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050048,GO:0050662,GO:0070279,GO:0070547,GO:0071704,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902221,GO:1902223 2.6.1.57 ko:K00832 ko00270,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01230,map00270,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01230 M00024,M00025,M00034,M00040 R00694,R00734,R01731,R07396,R10845 RC00006,RC00036 ko00000,ko00001,ko00002,ko01000,ko01007 - - iECED1_1282.ECED1_4768,iECSE_1348.ECSE_4347,iLF82_1304.LF82_2339,iNRG857_1313.NRG857_20250,iUTI89_1310.UTI89_C4629 Aminotran_1_2 k59_1486946_1 861299.J421_5794 3.65e-48 176.0 COG0515@1|root,COG0515@2|Bacteria,1ZUMJ@142182|Gemmatimonadetes 142182|Gemmatimonadetes KLT Protein kinase domain - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - PD40,Pkinase k59_17455_1 1122137.AQXF01000003_gene1899 8.56e-33 114.0 COG0254@1|root,COG0254@2|Bacteria,1MZ69@1224|Proteobacteria,2UBSC@28211|Alphaproteobacteria 28211|Alphaproteobacteria J 50S ribosomal protein L31 rpmE - - ko:K02909 ko03010,map03010 M00178 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L31 k59_17455_2 1122137.AQXF01000003_gene1900 3.33e-74 225.0 COG0071@1|root,COG0071@2|Bacteria,1RH2X@1224|Proteobacteria,2U96D@28211|Alphaproteobacteria 28211|Alphaproteobacteria O Belongs to the small heat shock protein (HSP20) family ibpA - - ko:K04080 - - - - ko00000,ko03110 - - - HSP20 k59_300440_1 436308.Nmar_0500 3.15e-194 546.0 COG0126@1|root,arCOG00496@2157|Archaea,41SMB@651137|Thaumarchaeota 651137|Thaumarchaeota G Phosphoglycerate kinase pgk - 2.7.2.3 ko:K00927 ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230 M00001,M00002,M00003,M00165,M00166,M00308,M00552 R01512 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000,ko04147 - - - PGK k59_1259858_1 765914.ThisiDRAFT_0750 6.72e-85 259.0 COG5433@1|root,COG5433@2|Bacteria,1MXB5@1224|Proteobacteria,1RSAV@1236|Gammaproteobacteria,1WXGN@135613|Chromatiales 135613|Chromatiales L PFAM Transposase - - - - - - - - - - - - DDE_Tnp_1,DDE_Tnp_1_assoc k59_469072_1 357808.RoseRS_1743 2.47e-20 102.0 COG4932@1|root,COG4932@2|Bacteria,2G7MG@200795|Chloroflexi,376NW@32061|Chloroflexia 32061|Chloroflexia M PFAM Cna B domain protein - - - - - - - - - - - - - k59_1599054_1 1122137.AQXF01000002_gene597 8.68e-127 381.0 COG0188@1|root,COG0188@2|Bacteria,1MURI@1224|Proteobacteria,2TQRQ@28211|Alphaproteobacteria 28211|Alphaproteobacteria L Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule parC - - ko:K02621 - - - - ko00000,ko01000,ko02048,ko03032,ko03036 - - - DNA_gyraseA_C,DNA_topoisoIV k59_1599054_2 883066.HMPREF9233_00753 2.45e-06 49.3 COG0454@1|root,COG0456@2|Bacteria,2ISDM@201174|Actinobacteria,4D3KF@85005|Actinomycetales 201174|Actinobacteria K Acetyltransferase (GNAT) domain - - 2.3.1.57 ko:K22441 - - - - ko00000,ko01000 - - - Acetyltransf_1,Acetyltransf_10 k59_921155_1 1134474.O59_001449 3.18e-32 123.0 COG2227@1|root,COG2227@2|Bacteria,1MY0S@1224|Proteobacteria,1RP69@1236|Gammaproteobacteria,1FH4D@10|Cellvibrio 1236|Gammaproteobacteria J Catalyzes the methylation of 5-carboxymethoxyuridine (cmo5U) to form 5-methoxycarbonylmethoxyuridine (mcmo5U) at position 34 in tRNAs cmoM GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016300,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:0097697,GO:0140098,GO:0140101,GO:1901360 - ko:K06219 - - - - ko00000 - - - Methyltransf_11,Methyltransf_23,Methyltransf_25,Methyltransf_31 k59_1146998_1 177437.HRM2_p00180 1.09e-187 542.0 COG4584@1|root,COG4584@2|Bacteria 2|Bacteria L PFAM Integrase catalytic - - - - - - - - - - - - HTH_38,HTH_7,rve k59_1146998_2 177437.HRM2_p00170 1.64e-109 321.0 COG1484@1|root,COG1484@2|Bacteria,1MZVC@1224|Proteobacteria,430QU@68525|delta/epsilon subdivisions,2WW1K@28221|Deltaproteobacteria,2MNR3@213118|Desulfobacterales 28221|Deltaproteobacteria L IstB-like ATP binding protein - - - - - - - - - - - - IstB_IS21 k59_1656326_1 1088721.NSU_1963 8.14e-50 174.0 COG4166@1|root,COG4166@2|Bacteria,1P91R@1224|Proteobacteria,2TT6P@28211|Alphaproteobacteria,2K08U@204457|Sphingomonadales 204457|Sphingomonadales E ABC-type oligopeptide transport system, periplasmic component - - - ko:K02035,ko:K15580 ko01501,ko02010,ko02024,map01501,map02010,map02024 M00239,M00439 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25 - - SBP_bac_5 k59_1035277_1 1123279.ATUS01000001_gene1316 3.89e-17 87.0 COG3249@1|root,COG3249@2|Bacteria,1N0PD@1224|Proteobacteria,1S9C4@1236|Gammaproteobacteria,1J69V@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S protein conserved in bacteria VV2512 - - ko:K09938 - - - - ko00000 - - - DUF2066 k59_412705_1 1122137.AQXF01000001_gene3384 2.18e-152 443.0 COG0138@1|root,COG0138@2|Bacteria,1MUDQ@1224|Proteobacteria,2TRMY@28211|Alphaproteobacteria 28211|Alphaproteobacteria F bifunctional purine biosynthesis protein PurH purH - 2.1.2.3,3.5.4.10 ko:K00602 ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523 M00048 R01127,R04560 RC00026,RC00263,RC00456 ko00000,ko00001,ko00002,ko01000,ko04147 - - - AICARFT_IMPCHas,MGS k59_1429385_1 1200792.AKYF01000021_gene5415 1.62e-31 121.0 COG1834@1|root,COG1834@2|Bacteria,1W71J@1239|Firmicutes,4HF31@91061|Bacilli,26UVQ@186822|Paenibacillaceae 91061|Bacilli E Amidinotransferase - - - - - - - - - - - - Amidinotransf k59_582178_1 436308.Nmar_1754 7.53e-164 469.0 COG0527@1|root,arCOG00861@2157|Archaea,41SFA@651137|Thaumarchaeota 651137|Thaumarchaeota E Belongs to the aspartokinase family - - 2.7.2.4 ko:K00928 ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230 M00016,M00017,M00018,M00033,M00525,M00526,M00527 R00480 RC00002,RC00043 ko00000,ko00001,ko00002,ko01000 - - - AA_kinase,ACT_7 k59_1090460_1 377629.TERTU_0384 1.26e-28 118.0 COG0668@1|root,COG0668@2|Bacteria,1N596@1224|Proteobacteria,1RQZP@1236|Gammaproteobacteria,2PNPK@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria M Mechanosensitive ion channel VP2168 - - ko:K03442 - - - - ko00000,ko02000 1.A.23.2 - - MS_channel k59_412718_2 246197.MXAN_3138 2.81e-93 301.0 COG2133@1|root,COG2133@2|Bacteria,1PER7@1224|Proteobacteria,4399G@68525|delta/epsilon subdivisions,2X4GV@28221|Deltaproteobacteria,2YYZS@29|Myxococcales 28221|Deltaproteobacteria G Glucose / Sorbosone dehydrogenase - - - - - - - - - - - - GSDH k59_300476_1 158500.BV97_02582 3.24e-101 310.0 COG0768@1|root,COG0768@2|Bacteria,1MUNY@1224|Proteobacteria,2TSHQ@28211|Alphaproteobacteria,2K0Y2@204457|Sphingomonadales 204457|Sphingomonadales M Cell division protein FtsI penicillin-binding protein ftsI - 3.4.16.4 ko:K03587 ko00550,ko01501,map00550,map01501 - - - ko00000,ko00001,ko01000,ko01011,ko03036 - - - PBP_dimer,Transpeptidase k59_357089_1 1502850.FG91_01882 2.1e-10 63.5 COG3828@1|root,COG3828@2|Bacteria,1R5XA@1224|Proteobacteria,2U51F@28211|Alphaproteobacteria,2KDTS@204457|Sphingomonadales 204457|Sphingomonadales S Trehalose utilisation - - - ko:K09992 - - - - ko00000 - - - ThuA k59_357089_2 247634.GPB2148_1730 4.21e-34 127.0 COG3828@1|root,COG3828@2|Bacteria,1RF65@1224|Proteobacteria,1SZ1Y@1236|Gammaproteobacteria 1236|Gammaproteobacteria S Trehalose utilisation - - - - - - - - - - - - ThuA k59_1035310_1 1415778.JQMM01000001_gene191 8.84e-15 78.2 COG3164@1|root,COG3164@2|Bacteria,1MXWF@1224|Proteobacteria,1RNUK@1236|Gammaproteobacteria,1J4SY@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria S Protein of unknown function yhdP GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0030288,GO:0030313,GO:0031224,GO:0031226,GO:0031975,GO:0042597,GO:0044425,GO:0044459,GO:0044464,GO:0071944 - - - - - - - - - - AsmA_2,DUF3971 k59_865552_2 113395.AXAI01000002_gene5235 1.24e-98 300.0 COG2141@1|root,COG2141@2|Bacteria,1MWDV@1224|Proteobacteria,2TV51@28211|Alphaproteobacteria,3JWDH@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria C Luciferase-like monooxygenase - - - - - - - - - - - - Bac_luciferase k59_865552_3 402881.Plav_1979 2.5e-98 303.0 COG4799@1|root,COG4799@2|Bacteria,1PFU5@1224|Proteobacteria,2UNSY@28211|Alphaproteobacteria,1JQ37@119043|Rhodobiaceae 28211|Alphaproteobacteria I Carboxyl transferase domain - - - - - - - - - - - - Carboxyl_trans k59_357099_2 586416.GZ22_16385 4.39e-11 64.3 COG1699@1|root,COG1699@2|Bacteria,1VA6Y@1239|Firmicutes,4HKYD@91061|Bacilli 91061|Bacilli S Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum fliW - - ko:K13626 - - - - ko00000,ko02035 - - - FliW k59_357099_3 1210884.HG799462_gene8925 7.17e-10 57.0 COG1551@1|root,COG1551@2|Bacteria,2J1KA@203682|Planctomycetes 203682|Planctomycetes T Global regulator protein family - - - ko:K03563 ko02020,ko02025,ko02026,ko05111,map02020,map02025,map02026,map05111 - - - ko00000,ko00001,ko03019 - - - CsrA k59_357099_4 1151122.AQYD01000006_gene1888 1.96e-10 63.5 COG1344@1|root,COG1344@2|Bacteria,2IA40@201174|Actinobacteria,4FN7N@85023|Microbacteriaceae 201174|Actinobacteria N Bacterial flagellin N-terminal helical region flgL - - ko:K02397 ko02040,map02040 - - - ko00000,ko00001,ko02035 - - - Flagellin_C,Flagellin_N k59_1599101_2 1401328.P856_186 9.32e-49 168.0 COG4123@1|root,COG4123@2|Bacteria,1MXEQ@1224|Proteobacteria,2TUBR@28211|Alphaproteobacteria,2JS20@204441|Rhodospirillales 204441|Rhodospirillales S Methyltransferase small domain - - - - - - - - - - - - MTS,PCMT k59_921222_1 1150626.PHAMO_280235 7.68e-42 154.0 COG3243@1|root,COG3243@2|Bacteria,1MU68@1224|Proteobacteria,2TR7S@28211|Alphaproteobacteria,2JQCH@204441|Rhodospirillales 204441|Rhodospirillales I Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus phbC - - ko:K03821 ko00650,map00650 - R04254 RC00004 ko00000,ko00001,ko01000 - - - Abhydrolase_1,PhaC_N k59_1259923_1 377629.TERTU_0246 3.94e-74 226.0 COG0669@1|root,COG0669@2|Bacteria,1RD9F@1224|Proteobacteria,1S41J@1236|Gammaproteobacteria,2PNGX@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria F Citrate lyase ligase C-terminal domain coaD GO:0003674,GO:0003824,GO:0004595,GO:0005488,GO:0005515,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0070566,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.7.7.3 ko:K00954 ko00770,ko01100,map00770,map01100 M00120 R03035 RC00002 ko00000,ko00001,ko00002,ko01000 - - iPC815.YPO0053,iSDY_1059.SDY_4064 CTP_transf_like k59_1487017_1 330084.JNYZ01000011_gene7390 6.92e-48 165.0 COG1804@1|root,COG1804@2|Bacteria,2GKNX@201174|Actinobacteria,4DYUC@85010|Pseudonocardiales 201174|Actinobacteria C PFAM CoA-transferase family III - - 5.1.99.4 ko:K01796 ko00120,ko01100,ko04146,map00120,map01100,map04146 M00104 R08734,R08739 RC02345 ko00000,ko00001,ko00002,ko01000 - - - CoA_transf_3 k59_1487017_2 1323663.AROI01000016_gene278 2.42e-163 485.0 COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,1RMZ8@1236|Gammaproteobacteria 1236|Gammaproteobacteria I Involved in the aerobic and anaerobic degradation of long-chain fatty acids via beta-oxidation cycle. Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA. It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate fadJ - 1.1.1.35,4.2.1.17,5.1.2.3 ko:K01782 ko00071,ko00280,ko00281,ko00310,ko00362,ko00380,ko00410,ko00640,ko00650,ko00903,ko00930,ko01040,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00362,map00380,map00410,map00640,map00650,map00903,map00930,map01040,map01100,map01110,map01120,map01130,map01200,map01212 M00032,M00087 R01975,R03026,R03045,R03276,R04137,R04170,R04203,R04204,R04224,R04737,R04738,R04739,R04740,R04741,R04744,R04745,R04746,R04748,R04749,R05066,R05305,R06411,R06412,R06941,R06942,R07935,R07951,R08093,R08094 RC00029,RC00099,RC00117,RC00241,RC00525,RC00831,RC00834,RC00896,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115 ko00000,ko00001,ko00002,ko01000 - - - 3HCDH,3HCDH_N,ECH_1 k59_130520_1 1123270.ATUR01000006_gene173 6.83e-113 334.0 COG1804@1|root,COG1804@2|Bacteria,1MWPB@1224|Proteobacteria,2U1YE@28211|Alphaproteobacteria,2K3RY@204457|Sphingomonadales 204457|Sphingomonadales C acyl-CoA transferase carnitine dehydratase - - - - - - - - - - - - CoA_transf_3 k59_808687_2 1333507.AUTQ01000194_gene4575 2.77e-14 73.2 COG1714@1|root,COG1714@2|Bacteria,1N4N8@1224|Proteobacteria,1S9C5@1236|Gammaproteobacteria,2PZYU@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria S membrane protein domain VP2641 - - - - - - - - - - - RDD k59_582212_2 1122137.AQXF01000003_gene2109 3.75e-49 166.0 COG1294@1|root,COG1294@2|Bacteria,1MURP@1224|Proteobacteria,2TU3I@28211|Alphaproteobacteria 28211|Alphaproteobacteria C oxidase subunit cydB - 1.10.3.14 ko:K00426 ko00190,ko01100,ko02020,map00190,map01100,map02020 M00153 R11325 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.4.3 - - Cyt_bd_oxida_II k59_1317113_1 436308.Nmar_0715 1.62e-49 160.0 COG1310@1|root,arCOG01139@2157|Archaea,41SQ7@651137|Thaumarchaeota 651137|Thaumarchaeota S metal-dependent protease of the PAD1 JAB1 superfamily - - - - - - - - - - - - Prok-JAB k59_1317113_2 436308.Nmar_1278 1.41e-11 60.8 arCOG08680@1|root,arCOG08680@2157|Archaea 436308.Nmar_1278|- - - - - - - - - - - - - - - - k59_921241_1 1123035.ARLA01000028_gene1904 1.6e-37 134.0 COG0694@1|root,COG0694@2|Bacteria,4NG0Q@976|Bacteroidetes,1HWKF@117743|Flavobacteriia,4C2VK@83612|Psychroflexus 976|Bacteroidetes O Scaffold protein Nfu/NifU N terminal - - - - - - - - - - - - Nfu_N,NifU k59_1429438_1 686340.Metal_1751 1.8e-54 196.0 COG0643@1|root,COG2198@1|root,COG0643@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,1RMS6@1236|Gammaproteobacteria,1XDPM@135618|Methylococcales 135618|Methylococcales T Signal transduction histidine kinase, phosphotransfer (Hpt) region - - 2.7.13.3 ko:K03407 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035 - - - CheW,H-kinase_dim,HATPase_c,Hpt k59_1768692_1 436308.Nmar_0948 6.26e-57 195.0 COG0417@1|root,arCOG15272@2157|Archaea,41S91@651137|Thaumarchaeota 651137|Thaumarchaeota L DNA polymerase - - 2.7.7.7 ko:K02319 ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030 - R00375,R00376,R00377,R00378 RC02795 ko00000,ko00001,ko01000,ko03032 - - - DNA_pol_B,DNA_pol_B_exo1 k59_1768692_2 436308.Nmar_0949 1.63e-27 101.0 COG4095@1|root,arCOG05022@2157|Archaea,41SUZ@651137|Thaumarchaeota 651137|Thaumarchaeota S Sugar efflux transporter for intercellular exchange - - - ko:K15383 - - - - ko00000,ko02000 9.A.58.2 - - MtN3_slv k59_130522_1 1122137.AQXF01000005_gene1180 3.68e-111 339.0 COG0556@1|root,COG0556@2|Bacteria,1MUFK@1224|Proteobacteria,2TQSP@28211|Alphaproteobacteria 28211|Alphaproteobacteria L damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage uvrB - - ko:K03702 ko03420,map03420 - - - ko00000,ko00001,ko03400 - - - Helicase_C,ResIII,UVR,UvrB k59_357131_1 857293.CAAU_1831 1.23e-16 83.2 COG1597@1|root,COG1597@2|Bacteria,1TQAU@1239|Firmicutes,25CN4@186801|Clostridia,36WY7@31979|Clostridiaceae 186801|Clostridia I Diacylglycerol kinase catalytic domain (presumed) - - - - - - - - - - - - DAGK_cat k59_582232_1 158500.BV97_00787 6.92e-84 251.0 COG0454@1|root,COG0456@2|Bacteria,1MYY6@1224|Proteobacteria,2UBIF@28211|Alphaproteobacteria,2K537@204457|Sphingomonadales 204457|Sphingomonadales K Acetyltransferase (GNAT) family - - - - - - - - - - - - Acetyltransf_1 k59_1317140_2 1415778.JQMM01000001_gene2182 1.79e-20 89.4 COG0224@1|root,COG0224@2|Bacteria,1RIE5@1224|Proteobacteria,1S3ZW@1236|Gammaproteobacteria 1236|Gammaproteobacteria C ATP synthase gamma subunit - - - ko:K02115 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt k59_638826_1 1286106.MPL1_01652 4.85e-48 159.0 COG2209@1|root,COG2209@2|Bacteria,1R33S@1224|Proteobacteria,1RMWV@1236|Gammaproteobacteria,4608S@72273|Thiotrichales 72273|Thiotrichales C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol nqrE - 1.6.5.8 ko:K00350 - - - - ko00000,ko01000 - - - Rnf-Nqr k59_638826_2 1121937.AUHJ01000005_gene2292 9.42e-33 119.0 COG1347@1|root,COG1347@2|Bacteria,1MUZR@1224|Proteobacteria,1RNFE@1236|Gammaproteobacteria,46413@72275|Alteromonadaceae 1236|Gammaproteobacteria C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol nqrD GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0006814,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015672,GO:0015980,GO:0016020,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0030001,GO:0030964,GO:0032991,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0044425,GO:0044464,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0051179,GO:0051234,GO:0055086,GO:0055114,GO:0071704,GO:0071944,GO:0072521,GO:0098796,GO:1901135,GO:1901360,GO:1901564,GO:1902494 1.6.5.8 ko:K00349 - - - - ko00000,ko01000 - - - Rnf-Nqr k59_1768697_2 7955.ENSDARP00000038472 4.63e-22 94.7 28PA3@1|root,2QVX9@2759|Eukaryota,39SGI@33154|Opisthokonta,3BC75@33208|Metazoa,3D3RW@33213|Bilateria,481QN@7711|Chordata,498PF@7742|Vertebrata,49YAX@7898|Actinopterygii 33208|Metazoa S Chromosome 16 open reading frame 13 C16orf13 - - - - - - - - - - - DUF938 k59_525125_1 479434.Sthe_1004 4.43e-33 127.0 COG0304@1|root,COG0304@2|Bacteria 2|Bacteria I 3-oxoacyl-[acyl-carrier-protein] synthase activity - - 2.3.1.179 ko:K09458 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119 RC00039,RC02728,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Ketoacyl-synt_C,ketoacyl-synt k59_1656385_1 316407.1800065 6.35e-38 136.0 COG4175@1|root,COG4175@2|Bacteria,1MU86@1224|Proteobacteria,1RN2R@1236|Gammaproteobacteria,3XMCF@561|Escherichia 1236|Gammaproteobacteria P glycine, betaine proV GO:0000166,GO:0003674,GO:0004888,GO:0005034,GO:0005215,GO:0005275,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006950,GO:0006970,GO:0006972,GO:0007154,GO:0007165,GO:0008144,GO:0008150,GO:0009628,GO:0009987,GO:0015695,GO:0015696,GO:0015697,GO:0015837,GO:0015838,GO:0016020,GO:0016021,GO:0017076,GO:0022857,GO:0023052,GO:0030554,GO:0031224,GO:0031460,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0035639,GO:0036094,GO:0038023,GO:0043167,GO:0043168,GO:0043190,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051179,GO:0051234,GO:0051716,GO:0055085,GO:0060089,GO:0065007,GO:0071702,GO:0071705,GO:0071944,GO:0072337,GO:0097159,GO:0097367,GO:0098533,GO:0098796,GO:0098797,GO:1901265,GO:1901363,GO:1902494,GO:1902495,GO:1904949,GO:1990351 3.6.3.32 ko:K02000 ko02010,map02010 M00208 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1.12 - iAF1260.b2677,iB21_1397.B21_02497,iBWG_1329.BWG_2420,iEC042_1314.EC042_2875,iEC55989_1330.EC55989_2945,iECBD_1354.ECBD_1042,iECB_1328.ECB_02533,iECDH1ME8569_1439.ECDH1ME8569_2593,iECD_1391.ECD_02533,iECED1_1282.ECED1_3132,iECIAI1_1343.ECIAI1_2773,iECO103_1326.ECO103_3218,iECO111_1330.ECO111_3401,iECO26_1355.ECO26_3746,iECSE_1348.ECSE_2930,iECW_1372.ECW_m2874,iEKO11_1354.EKO11_1094,iETEC_1333.ETEC_2874,iEcDH1_1363.EcDH1_1006,iEcE24377_1341.EcE24377A_2958,iEcolC_1368.EcolC_1029,iG2583_1286.G2583_3325,iJO1366.b2677,iJR904.b2677,iPC815.YPO2647,iSBO_1134.SBO_2839,iSbBS512_1146.SbBS512_E3202,iUMNK88_1353.UMNK88_3346,iWFL_1372.ECW_m2874,iY75_1357.Y75_RS13940,iYL1228.KPN_03008 ABC_tran,CBS k59_808710_1 292564.Cyagr_2650 8.21e-41 139.0 COG1247@1|root,COG1247@2|Bacteria,1G64C@1117|Cyanobacteria,22TF2@167375|Cyanobium 1117|Cyanobacteria M Acetyltransferase (GNAT) domain - - - - - - - - - - - - Acetyltransf_1 k59_187357_1 1869.MB27_40275 2.35e-15 78.6 COG1744@1|root,COG1744@2|Bacteria,2GMFS@201174|Actinobacteria,4DAD7@85008|Micromonosporales 201174|Actinobacteria S basic membrane - - - ko:K07335 - - - - ko00000 - - - Bmp k59_187357_2 1123488.ATUF01000002_gene585 1.01e-33 132.0 COG0542@1|root,COG0542@2|Bacteria,2GJ77@201174|Actinobacteria,4D3Q7@85005|Actinomycetales 201174|Actinobacteria O ATPase family associated with various cellular activities (AAA) clpC GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006457,GO:0008150,GO:0009987,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030312,GO:0040007,GO:0042802,GO:0042803,GO:0044183,GO:0044424,GO:0044444,GO:0044464,GO:0046983,GO:0071944 - ko:K03696 ko01100,map01100 - - - ko00000,ko03110 - - - AAA,AAA_2,ClpB_D2-small,Clp_N,UVR k59_301919_1 316407.1742352 4.36e-134 390.0 COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,1RMBQ@1236|Gammaproteobacteria,3XN8Z@561|Escherichia 1236|Gammaproteobacteria C Catalyzes the oxidation of 1-pyrroline, which is spontaneously formed from 4-aminobutanal, leading to 4- aminobutanoate (GABA) prr GO:0003674,GO:0003824,GO:0004029,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006576,GO:0006595,GO:0006598,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009308,GO:0009310,GO:0009445,GO:0009447,GO:0009987,GO:0016491,GO:0016620,GO:0016903,GO:0019145,GO:0033737,GO:0034641,GO:0042402,GO:0042802,GO:0044106,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0055114,GO:0071704,GO:0097164,GO:1901564,GO:1901565,GO:1901575 1.2.1.19 ko:K00137 ko00330,ko00410,ko01100,map00330,map00410,map01100 - R02549 RC00080 ko00000,ko00001,ko01000 - - iAF1260.b1444,iBWG_1329.BWG_1269,iECDH10B_1368.ECDH10B_1574,iECDH1ME8569_1439.ECDH1ME8569_1387,iEcDH1_1363.EcDH1_2202,iJO1366.b1444,iY75_1357.Y75_RS07595 Aldedh k59_583413_1 1344012.ATMI01000056_gene1774 2.92e-12 66.2 COG0304@1|root,COG0304@2|Bacteria,1MU1X@1224|Proteobacteria,1RMDE@1236|Gammaproteobacteria,4BTPY@82986|Tatumella 1236|Gammaproteobacteria IQ Beta-ketoacyl synthase, N-terminal domain fabB GO:0003674,GO:0003824,GO:0004312,GO:0004315,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0072330,GO:1901576 2.3.1.41 ko:K00647 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119 RC00039,RC02728,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - iAF1260.b2323,iAPECO1_1312.APECO1_4241,iB21_1397.B21_02208,iBWG_1329.BWG_2097,iE2348C_1286.E2348C_2463,iEC042_1314.EC042_2564,iEC55989_1330.EC55989_2567,iECABU_c1320.ECABU_c26560,iECBD_1354.ECBD_1336,iECB_1328.ECB_02248,iECDH10B_1368.ECDH10B_2485,iECDH1ME8569_1439.ECDH1ME8569_2261,iECD_1391.ECD_02248,iECED1_1282.ECED1_2787,iECIAI1_1343.ECIAI1_2400,iECIAI39_1322.ECIAI39_2472,iECNA114_1301.ECNA114_2414,iECO103_1326.ECO103_2787,iECO111_1330.ECO111_3071,iECO26_1355.ECO26_3311,iECOK1_1307.ECOK1_2605,iECP_1309.ECP_2362,iECS88_1305.ECS88_2471,iECSE_1348.ECSE_2632,iECSF_1327.ECSF_2200,iECUMN_1333.ECUMN_2663,iECW_1372.ECW_m2512,iEKO11_1354.EKO11_1442,iETEC_1333.ETEC_2459,iEcDH1_1363.EcDH1_1333,iEcHS_1320.EcHS_A2474,iEcSMS35_1347.EcSMS35_2480,iEcolC_1368.EcolC_1329,iJN746.PP_4175,iJO1366.b2323,iJR904.b2323,iLF82_1304.LF82_0605,iNRG857_1313.NRG857_11765,iSBO_1134.SBO_2360,iUMN146_1321.UM146_05195,iUTI89_1310.UTI89_C2608,iWFL_1372.ECW_m2512,iY75_1357.Y75_RS12180,ic_1306.c2869 Ketoacyl-synt_C,ketoacyl-synt k59_583413_2 1415778.JQMM01000001_gene1209 1.74e-46 153.0 COG0764@1|root,COG0764@2|Bacteria,1MWV8@1224|Proteobacteria,1RP6W@1236|Gammaproteobacteria,1J5PF@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria I Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length fabA GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0008693,GO:0009058,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016860,GO:0016863,GO:0019171,GO:0019752,GO:0032787,GO:0034017,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0047451,GO:0071704,GO:0072330,GO:1901576 4.2.1.59,5.3.3.14 ko:K01716 ko00061,ko01100,ko01212,map00061,map01100,map01212 M00083 R04428,R04535,R04537,R04544,R04568,R04954,R04965,R07639 RC00831,RC01078,RC01095 ko00000,ko00001,ko00002,ko01000,ko01004 - - iAF1260.b0954,iB21_1397.B21_00965,iBWG_1329.BWG_0806,iE2348C_1286.E2348C_0940,iEC042_1314.EC042_1039,iECBD_1354.ECBD_2641,iECB_1328.ECB_00958,iECDH10B_1368.ECDH10B_1024,iECD_1391.ECD_00958,iECED1_1282.ECED1_0977,iECH74115_1262.ECH74115_1118,iECIAI1_1343.ECIAI1_0995,iECIAI39_1322.ECIAI39_2193,iECNA114_1301.ECNA114_1032,iECO103_1326.ECO103_1000,iECO111_1330.ECO111_1022,iECO26_1355.ECO26_1081,iECOK1_1307.ECOK1_1013,iECS88_1305.ECS88_0975,iECSF_1327.ECSF_0868,iECSP_1301.ECSP_1060,iECUMN_1333.ECUMN_1143,iECW_1372.ECW_m1064,iECs_1301.ECs1038,iEKO11_1354.EKO11_2876,iETEC_1333.ETEC_1024,iEcE24377_1341.EcE24377A_1068,iEcHS_1320.EcHS_A1063,iEcSMS35_1347.EcSMS35_2166,iEcolC_1368.EcolC_2642,iG2583_1286.G2583_1189,iJO1366.b0954,iJR904.b0954,iLF82_1304.LF82_0604,iSBO_1134.SBO_2277,iSDY_1059.SDY_0927,iSF_1195.SF0954,iSSON_1240.SSON_0958,iSbBS512_1146.SbBS512_E2362,iUMNK88_1353.UMNK88_1108,iWFL_1372.ECW_m1064,iY75_1357.Y75_RS04955,iZ_1308.Z1304,ic_1306.c1090 FabA k59_1205076_1 396588.Tgr7_0340 7.46e-38 141.0 COG0243@1|root,COG0243@2|Bacteria,1P01N@1224|Proteobacteria,1RQK9@1236|Gammaproteobacteria,1WWPF@135613|Chromatiales 135613|Chromatiales C Belongs to the prokaryotic molybdopterin-containing oxidoreductase family - - 1.8.5.6 ko:K21307 ko00920,ko01100,ko01120,map00920,map01100,map01120 - R11487 RC00168 ko00000,ko00001,ko01000 - - - Molybdop_Fe4S4,Molybdopterin,Molydop_binding k59_1205076_2 194439.CT0862 7.32e-80 249.0 COG2046@1|root,COG2046@2|Bacteria,1FF05@1090|Chlorobi 1090|Chlorobi F sulfate assimilation sat - 2.7.7.4 ko:K00958 ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130 M00176,M00596 R00529,R04929 RC02809,RC02889 ko00000,ko00001,ko00002,ko01000 - - - ATP-sulfurylase,PUA_2 k59_1148276_1 1123261.AXDW01000007_gene2358 6.62e-31 117.0 COG3137@1|root,COG3137@2|Bacteria,1MWI4@1224|Proteobacteria,1RN4J@1236|Gammaproteobacteria,1X57Z@135614|Xanthomonadales 135614|Xanthomonadales M salt-induced outer membrane protein - - - ko:K07283 - - - - ko00000 - - - DUF481 k59_752995_1 1178825.ALIH01000003_gene2076 6.58e-31 113.0 COG2370@1|root,COG2370@2|Bacteria,4NMRP@976|Bacteroidetes,1I1ES@117743|Flavobacteriia 976|Bacteroidetes O HupE UreJ protein - - - - - - - - - - - - HupE_UreJ_2 k59_752995_2 1121896.JMLU01000001_gene1034 7.76e-18 82.8 COG0582@1|root,COG0582@2|Bacteria,4NDZJ@976|Bacteroidetes,1HZ88@117743|Flavobacteriia,2NU4R@237|Flavobacterium 976|Bacteroidetes L Phage integrase SAM-like domain - - - - - - - - - - - - Phage_int_SAM_5,Phage_integrase k59_1713358_1 203122.Sde_0390 1.41e-26 112.0 COG0642@1|root,COG2202@1|root,COG3447@1|root,COG3614@1|root,COG3829@1|root,COG2202@2|Bacteria,COG2205@2|Bacteria,COG3447@2|Bacteria,COG3614@2|Bacteria,COG3829@2|Bacteria,1NRP8@1224|Proteobacteria,1SKTW@1236|Gammaproteobacteria 1236|Gammaproteobacteria T Histidine kinase - - - - - - - - - - - - HATPase_c,HisKA,PAS,PAS_9,Response_reg k59_244427_1 1122137.AQXF01000003_gene2450 6.03e-84 253.0 COG0207@1|root,COG0207@2|Bacteria,1MUBD@1224|Proteobacteria,2TQSB@28211|Alphaproteobacteria 28211|Alphaproteobacteria F Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis thyA - 2.1.1.45 ko:K00560 ko00240,ko00670,ko01100,ko01523,map00240,map00670,map01100,map01523 M00053 R02101 RC00219,RC00332 ko00000,ko00001,ko00002,ko01000 - - - Thymidylat_synt k59_1430684_1 153948.NAL212_3112 1.36e-76 235.0 COG1825@1|root,COG1825@2|Bacteria,1RDH0@1224|Proteobacteria,2VQNU@28216|Betaproteobacteria,37239@32003|Nitrosomonadales 28216|Betaproteobacteria J This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance ctc - - ko:K02897 ko03010,map03010 M00178 - - ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L25p,Ribosomal_TL5_C k59_1769972_2 1499967.BAYZ01000170_gene5495 1.6e-66 209.0 COG5405@1|root,COG5405@2|Bacteria 2|Bacteria O Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery - - 3.4.25.2 ko:K01419 - - - - ko00000,ko01000,ko01002 - - - Proteasome k59_1769972_3 1410620.SHLA_75c000350 1.76e-07 53.9 COG1846@1|root,COG1846@2|Bacteria,1N78T@1224|Proteobacteria,2U8T0@28211|Alphaproteobacteria,4B76B@82115|Rhizobiaceae 28211|Alphaproteobacteria K helix_turn_helix multiple antibiotic resistance protein - - - ko:K06075 - - - - ko00000,ko03000 - - - MarR,MarR_2 k59_1501607_1 675814.VIC_001995 2.27e-14 75.5 COG3772@1|root,COG3772@2|Bacteria,1N30X@1224|Proteobacteria,1SA8Q@1236|Gammaproteobacteria,1XY6Z@135623|Vibrionales 135623|Vibrionales S lysozyme VP1109 - - - - - - - - - - - - k59_32325_1 330214.NIDE0584 3.23e-10 63.9 COG0642@1|root,COG0784@1|root,COG2202@1|root,COG0784@2|Bacteria,COG2202@2|Bacteria,COG2205@2|Bacteria,3J0ZF@40117|Nitrospirae 2|Bacteria T Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology - - - - - - - - - - - - CHASE3,CHASE8,GAF,GAF_2,HAMP,HATPase_c,HisKA,Hpt,PAS,PAS_3,PAS_4,PAS_7,PAS_8,PAS_9,Response_reg k59_480122_2 1304275.C41B8_14025 8.82e-89 277.0 COG2072@1|root,COG2072@2|Bacteria,1MUQH@1224|Proteobacteria,1RPJY@1236|Gammaproteobacteria 1236|Gammaproteobacteria P flavoprotein involved in K transport - - - - - - - - - - - - Abhydrolase_3,FMO-like,NAD_binding_8,Pyr_redox_3 k59_1217868_2 1042377.AFPJ01000052_gene1538 3.01e-48 160.0 COG1596@1|root,COG1596@2|Bacteria,1MXYS@1224|Proteobacteria,1SC60@1236|Gammaproteobacteria,467H9@72275|Alteromonadaceae 1236|Gammaproteobacteria M COG1596 Periplasmic protein involved in polysaccharide export gumB - - ko:K20988 ko05111,map05111 - - - ko00000,ko00001,ko02000 1.B.18 - - Poly_export,SLBB k59_371918_1 522306.CAP2UW1_1652 2.51e-28 116.0 COG4232@1|root,COG4233@1|root,COG4232@2|Bacteria,COG4233@2|Bacteria,1MU8W@1224|Proteobacteria,2VI8I@28216|Betaproteobacteria,1KQEJ@119066|unclassified Betaproteobacteria 28216|Betaproteobacteria CO Disulphide bond corrector protein DsbC - - 1.8.1.8 ko:K04084,ko:K08344 - - - - ko00000,ko01000,ko02000,ko03110 5.A.1.1,5.A.1.5 - - DsbC,DsbD,Thioredoxin_7 k59_371921_1 754436.JCM19237_4220 8.76e-49 164.0 COG1842@1|root,COG1842@2|Bacteria,1NC7S@1224|Proteobacteria,1RS0G@1236|Gammaproteobacteria,1XUJH@135623|Vibrionales 135623|Vibrionales KT COG1842 Phage shock protein A (IM30), suppresses sigma54-dependent transcription pspA - - ko:K03969 - - - - ko00000 - - - PspA_IM30 k59_988063_1 1121890.AUDO01000007_gene2580 7.38e-62 202.0 COG0673@1|root,COG0673@2|Bacteria,4NE07@976|Bacteroidetes,1HY1C@117743|Flavobacteriia,2NUJ7@237|Flavobacterium 976|Bacteroidetes S Oxidoreductase family, NAD-binding Rossmann fold - - - - - - - - - - - - GFO_IDH_MocA k59_988063_2 555500.I215_02483 1.09e-10 61.6 COG1104@1|root,COG1104@2|Bacteria,4NFF6@976|Bacteroidetes,1HXF8@117743|Flavobacteriia 976|Bacteroidetes E Cysteine desulfurase iscS - 2.8.1.7 ko:K04487 ko00730,ko01100,ko04122,map00730,map01100,map04122 - R07460,R11528,R11529 RC01789,RC02313 ko00000,ko00001,ko01000,ko02048,ko03016,ko03029 - - - Aminotran_5 k59_424568_1 1177154.Y5S_00372 2.13e-69 224.0 COG3303@1|root,COG3303@2|Bacteria,1R5JF@1224|Proteobacteria,1S13K@1236|Gammaproteobacteria,1XNJE@135619|Oceanospirillales 135619|Oceanospirillales C Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process - - - - - - - - - - - - Cytochrom_c3_2 k59_535410_1 1122137.AQXF01000006_gene789 3.27e-86 261.0 COG0010@1|root,COG0010@2|Bacteria,1MVFH@1224|Proteobacteria,2TR41@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Belongs to the arginase family speB - 3.5.3.11 ko:K01480 ko00330,ko01100,map00330,map01100 M00133 R01157 RC00024,RC00329 ko00000,ko00001,ko00002,ko01000 - - - Arginase k59_199541_1 990285.RGCCGE502_10276 9.65e-69 232.0 COG0403@1|root,COG1003@1|root,COG0403@2|Bacteria,COG1003@2|Bacteria,1MUDP@1224|Proteobacteria,2TSFF@28211|Alphaproteobacteria,4BB0S@82115|Rhizobiaceae 28211|Alphaproteobacteria E The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor gcvP - 1.4.4.2 ko:K00281,ko:K00283 ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200 M00532 R01221,R03425 RC00022,RC00929,RC02834,RC02880 ko00000,ko00001,ko00002,ko01000 - - - Aminotran_5,GDC-P k59_199541_2 1211815.CBYP010000014_gene3514 7.2e-27 107.0 COG0392@1|root,COG0392@2|Bacteria 2|Bacteria M lysyltransferase activity - - - ko:K07027,ko:K20468 - - - - ko00000,ko02000 4.D.2,4.D.2.4.1 - - LPG_synthase_TM k59_315215_2 1122137.AQXF01000003_gene2060 8e-53 169.0 COG1522@1|root,COG1522@2|Bacteria,1MXVU@1224|Proteobacteria,2TTCK@28211|Alphaproteobacteria 28211|Alphaproteobacteria K Transcriptional lrp GO:0001101,GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006355,GO:0006520,GO:0006522,GO:0006524,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009078,GO:0009080,GO:0009889,GO:0009987,GO:0010033,GO:0010243,GO:0010468,GO:0010556,GO:0016054,GO:0019219,GO:0019222,GO:0019752,GO:0031323,GO:0031326,GO:0042221,GO:0043200,GO:0043201,GO:0043436,GO:0043565,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606,GO:1901698,GO:1901700,GO:1903506,GO:2000112,GO:2001141 - - - - - - - - - - AsnC_trans_reg,HTH_24 k59_1725848_1 1122194.AUHU01000002_gene2622 6.46e-41 154.0 COG1197@1|root,COG1197@2|Bacteria,1MUXG@1224|Proteobacteria,1RNCU@1236|Gammaproteobacteria,464IX@72275|Alteromonadaceae 1236|Gammaproteobacteria L Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site mfd GO:0000715,GO:0000716,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006283,GO:0006289,GO:0006355,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008094,GO:0008150,GO:0008152,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0015616,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019219,GO:0019222,GO:0019899,GO:0031323,GO:0031326,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0043175,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0051276,GO:0051716,GO:0060255,GO:0065007,GO:0070063,GO:0071704,GO:0071840,GO:0080090,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1903506,GO:2000112,GO:2001141 - ko:K03723 ko03420,map03420 - - - ko00000,ko00001,ko01000,ko03400 - - - CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF k59_32358_1 1353528.DT23_12525 5.87e-12 65.5 COG0578@1|root,COG0578@2|Bacteria,1MUMY@1224|Proteobacteria,2TU11@28211|Alphaproteobacteria,2XMH0@285107|Thioclava 28211|Alphaproteobacteria C Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family - - 1.1.5.3 ko:K00111 ko00564,ko01110,map00564,map01110 - R00848 RC00029 ko00000,ko00001,ko01000 - - - DAO k59_1558615_2 756067.MicvaDRAFT_3523 4.04e-63 212.0 COG0337@1|root,COG0337@2|Bacteria,1G03C@1117|Cyanobacteria,1H7F8@1150|Oscillatoriales 1117|Cyanobacteria E Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ) aroB - 4.2.3.4 ko:K01735 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R03083 RC00847 ko00000,ko00001,ko00002,ko01000 - - - DHQ_synthase k59_1558615_3 32057.KB217478_gene3903 2.83e-07 53.5 COG0703@1|root,COG0703@2|Bacteria,1G5QW@1117|Cyanobacteria,1HJXP@1161|Nostocales 1117|Cyanobacteria F Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate aroK GO:0000287,GO:0003674,GO:0003824,GO:0004765,GO:0005488,GO:0006082,GO:0006520,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019438,GO:0019632,GO:0019752,GO:0032787,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046872,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615 2.7.1.71 ko:K00891 ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230 M00022 R02412 RC00002,RC00078 ko00000,ko00001,ko00002,ko01000 - - - SKI k59_762454_1 1229909.NSED_09155 3.06e-81 248.0 COG1701@1|root,arCOG04262@2157|Archaea,41SXP@651137|Thaumarchaeota 651137|Thaumarchaeota S Pfam:DUF137 - - 6.3.2.36 ko:K09722 ko00410,ko00770,ko01100,map00410,map00770,map01100 - R09379 RC00096,RC00141 ko00000,ko00001,ko01000 - - - PPS_PS k59_424583_1 1005395.CSV86_06436 5.97e-06 49.7 2E80T@1|root,332F0@2|Bacteria,1N7RY@1224|Proteobacteria,1SCE8@1236|Gammaproteobacteria,1YYSI@136845|Pseudomonas putida group 1236|Gammaproteobacteria S Domain of unknown function (DUF4389) - - - - - - - - - - - - DUF4389 k59_1501656_2 1056820.KB900657_gene4153 3.18e-31 120.0 COG0451@1|root,COG0451@2|Bacteria,1Q2DG@1224|Proteobacteria,1RSQB@1236|Gammaproteobacteria,2PP9M@256005|Alteromonadales genera incertae sedis 1236|Gammaproteobacteria GM GDP-mannose 4,6 dehydratase - - - - - - - - - - - - Epimerase k59_988088_1 1229909.NSED_09215 4.63e-113 333.0 COG0075@1|root,arCOG00082@2157|Archaea,41SZZ@651137|Thaumarchaeota 651137|Thaumarchaeota E Aminotransferase class-V - - - - - - - - - - - - Aminotran_5 k59_1388507_1 316407.85675822 8.56e-89 280.0 COG0188@1|root,COG0188@2|Bacteria,1MURI@1224|Proteobacteria,1RMTC@1236|Gammaproteobacteria,3XNES@561|Escherichia 1236|Gammaproteobacteria L Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule parC GO:0000819,GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006265,GO:0006276,GO:0006725,GO:0006807,GO:0006996,GO:0007049,GO:0007059,GO:0007062,GO:0008150,GO:0008152,GO:0009330,GO:0009987,GO:0016020,GO:0016043,GO:0019897,GO:0019898,GO:0022402,GO:0030541,GO:0032991,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0046483,GO:0051276,GO:0071103,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:0098813,GO:1901360,GO:1901363 - ko:K02621 - - - - ko00000,ko01000,ko02048,ko03032,ko03036 - - - DNA_gyraseA_C,DNA_topoisoIV k59_1388507_2 1440052.EAKF1_ch2906 1.77e-07 51.2 COG4166@1|root,COG4166@2|Bacteria,1R9KS@1224|Proteobacteria,1RWN5@1236|Gammaproteobacteria,3XNUG@561|Escherichia 1236|Gammaproteobacteria E higher expression in the presence of deoxycholate inhibits cell growth completely. Bile acid detergents such as deoxycholate are important for host defense against bacterial growth in the gall bladder and duodenum ygiS GO:0005575,GO:0005623,GO:0006810,GO:0006811,GO:0006820,GO:0006869,GO:0008150,GO:0010876,GO:0015711,GO:0015718,GO:0015721,GO:0015849,GO:0015850,GO:0030288,GO:0030313,GO:0031975,GO:0033036,GO:0042597,GO:0044464,GO:0046942,GO:0051179,GO:0051234,GO:0071702 - ko:K02035 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - SBP_bac_5 k59_1725873_1 158500.BV97_02653 1.06e-102 318.0 COG0744@1|root,COG0744@2|Bacteria,1QTST@1224|Proteobacteria,2TQQ8@28211|Alphaproteobacteria,2K0HX@204457|Sphingomonadales 204457|Sphingomonadales M penicillin-binding protein - - 2.4.1.129,3.4.16.4 ko:K05366 ko00550,ko01100,ko01501,map00550,map01100,map01501 - - - ko00000,ko00001,ko01000,ko01003,ko01011 - GT51 - Transgly,Transpeptidase k59_932366_1 1191523.MROS_2556 8.96e-36 132.0 COG0482@1|root,COG0482@2|Bacteria 2|Bacteria J sulfurtransferase activity mnmA - 2.8.1.13 ko:K00566 ko04122,map04122 - R08700 RC02313,RC02315 ko00000,ko00001,ko01000,ko03016 - - - tRNA_Me_trans k59_596678_2 765912.Thimo_1384 2.51e-63 204.0 COG1064@1|root,COG1064@2|Bacteria,1MUTT@1224|Proteobacteria,1RPQC@1236|Gammaproteobacteria,1X2A7@135613|Chromatiales 135613|Chromatiales S alcohol dehydrogenase - - 1.1.1.1 ko:K13953 ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220 - R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310 RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273 ko00000,ko00001,ko01000 - - - ADH_N k59_1501680_1 765913.ThidrDRAFT_3524 8.51e-13 68.6 COG1215@1|root,COG5309@1|root,COG1215@2|Bacteria,COG5309@2|Bacteria,1MWF8@1224|Proteobacteria,1S08E@1236|Gammaproteobacteria,1WXTS@135613|Chromatiales 135613|Chromatiales M PFAM Glycosyl transferase family 2 - - - - - - - - - - - - Glyco_tranf_2_3 k59_1327958_1 1122138.AQUZ01000004_gene1047 4.43e-75 240.0 COG4695@1|root,COG4695@2|Bacteria,2I9PX@201174|Actinobacteria 201174|Actinobacteria S Phage portal protein - - - - - - - - - - - - Phage_portal k59_1440690_1 702113.PP1Y_AT34888 9.82e-248 704.0 COG2844@1|root,COG2844@2|Bacteria,1MV54@1224|Proteobacteria,2TSV0@28211|Alphaproteobacteria,2K0BN@204457|Sphingomonadales 204457|Sphingomonadales O Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen glnD - 2.7.7.59 ko:K00990 ko02020,map02020 - - - ko00000,ko00001,ko01000 - - - DUF294,GlnD_UR_UTase,HD k59_762479_1 1123320.KB889585_gene1917 1.08e-27 115.0 COG1960@1|root,COG1960@2|Bacteria,2GKVN@201174|Actinobacteria 201174|Actinobacteria I acyl-CoA dehydrogenase - - - - - - - - - - - - Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N k59_1667978_1 313596.RB2501_11057 1.87e-109 324.0 COG0216@1|root,COG0216@2|Bacteria,4NF72@976|Bacteroidetes,1HYAP@117743|Flavobacteriia 976|Bacteroidetes J Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA prfA - - ko:K02835 - - - - ko00000,ko03012 - - - PCRF,RF-1 k59_989432_1 1122137.AQXF01000004_gene1863 4.45e-165 483.0 COG0739@1|root,COG0739@2|Bacteria,1MVTF@1224|Proteobacteria,2TT3Z@28211|Alphaproteobacteria 28211|Alphaproteobacteria M COG0739 Membrane proteins related to metalloendopeptidases nlpD2 - - - - - - - - - - - Peptidase_M23 k59_1669372_1 96561.Dole_0294 1.01e-63 206.0 COG0533@1|root,COG0533@2|Bacteria,1MU6S@1224|Proteobacteria,42MHX@68525|delta/epsilon subdivisions,2WIKS@28221|Deltaproteobacteria,2MI6H@213118|Desulfobacterales 28221|Deltaproteobacteria J Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction tsaD GO:0000408,GO:0002949,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:1901360 2.3.1.234 ko:K01409 - - R10648 RC00070,RC00416 ko00000,ko01000,ko03016 - - - Peptidase_M22 k59_1669372_2 1121438.JNJA01000010_gene1987 2.12e-23 94.4 COG1734@1|root,COG1734@2|Bacteria,1RD08@1224|Proteobacteria,42RVK@68525|delta/epsilon subdivisions,2WNNA@28221|Deltaproteobacteria,2MC4D@213115|Desulfovibrionales 28221|Deltaproteobacteria T Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters dksA - - ko:K06204 ko02026,map02026 - - - ko00000,ko00001,ko03000,ko03009,ko03021 - - - zf-dskA_traR k59_1560677_2 66875.JODY01000009_gene2043 1.07e-08 57.0 COG2124@1|root,COG2124@2|Bacteria,2GJ8V@201174|Actinobacteria 201174|Actinobacteria Q cytochrome p450 - - - - - - - - - - - - p450 k59_821812_1 1229909.NSED_00615 9.01e-93 288.0 COG1001@1|root,arCOG00693@2157|Archaea,41SZH@651137|Thaumarchaeota 651137|Thaumarchaeota F Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family ade - 3.5.4.2 ko:K01486 ko00230,ko01100,map00230,map01100 - R01244 RC00477 ko00000,ko00001,ko01000 - - - Adenine_deam_C,Amidohydro_1 k59_1614613_1 1380355.JNIJ01000004_gene2825 1.52e-53 180.0 COG1013@1|root,COG1013@2|Bacteria,1R5BF@1224|Proteobacteria,2TR4R@28211|Alphaproteobacteria,3JTAE@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria C Thiamine pyrophosphate enzyme, C-terminal TPP binding domain MA20_01040 - 1.2.7.11,1.2.7.3 ko:K00175 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00009,M00011,M00173,M00620 R01196,R01197 RC00004,RC02742,RC02833 br01601,ko00000,ko00001,ko00002,ko01000 - - - PFO_beta_C,TPP_enzyme_C k59_536674_1 272942.RCAP_rcc02668 1.25e-39 144.0 COG0304@1|root,COG0304@2|Bacteria,1MU1X@1224|Proteobacteria,2TQYV@28211|Alphaproteobacteria,1FBDF@1060|Rhodobacter 28211|Alphaproteobacteria H Belongs to the beta-ketoacyl-ACP synthases family fabB GO:0003674,GO:0003824,GO:0004312,GO:0004315,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0072330,GO:1901576 2.3.1.41 ko:K00647 ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212 M00083,M00572 R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119 RC00039,RC02728,RC02729,RC02888 ko00000,ko00001,ko00002,ko01000,ko01004 - - - Ketoacyl-synt_C,ketoacyl-synt k59_536674_2 983545.Glaag_2976 1.05e-24 101.0 COG0372@1|root,COG0372@2|Bacteria,1MUKX@1224|Proteobacteria,1RNT1@1236|Gammaproteobacteria,465RE@72275|Alteromonadaceae 1236|Gammaproteobacteria C Belongs to the citrate synthase family prpC GO:0003674,GO:0003824,GO:0004108,GO:0006082,GO:0006091,GO:0006113,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0009987,GO:0015980,GO:0016740,GO:0016746,GO:0016829,GO:0016830,GO:0016833,GO:0016999,GO:0017144,GO:0019541,GO:0019679,GO:0019752,GO:0032787,GO:0036440,GO:0043436,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0046459,GO:0046912,GO:0050440,GO:0055114,GO:0071704 2.3.3.5 ko:K01659 ko00640,map00640 - R00931 RC00004,RC00406,RC02827 ko00000,ko00001,ko01000 - - iECED1_1282.ECED1_0365,iECIAI1_1343.ECIAI1_0334,iECIAI39_1322.ECIAI39_0347,iECP_1309.ECP_0408,iECSF_1327.ECSF_0308,iEcE24377_1341.EcE24377A_0357,iJN746.PP_2335,iLF82_1304.LF82_1740,iNRG857_1313.NRG857_01630 Citrate_synt k59_90494_1 1313172.YM304_04550 6.43e-21 95.1 COG2146@1|root,COG2146@2|Bacteria,2GQWS@201174|Actinobacteria 201174|Actinobacteria P Rieske [2Fe-2S] domain - - - ko:K15762 ko00623,ko00920,ko01100,ko01120,ko01220,map00623,map00920,map01100,map01120,map01220 M00538 R02550,R03562,R05666,R09513 RC00269,RC00490,RC02556 ko00000,ko00001,ko00002 - - - Rieske k59_90495_1 1167006.UWK_01686 8.19e-63 209.0 COG0297@1|root,COG0297@2|Bacteria,1MUGM@1224|Proteobacteria,42MT8@68525|delta/epsilon subdivisions,2WITI@28221|Deltaproteobacteria,2MKJ1@213118|Desulfobacterales 28221|Deltaproteobacteria G synthase glgA GO:0000271,GO:0003674,GO:0003824,GO:0004373,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0006073,GO:0006091,GO:0006112,GO:0008150,GO:0008152,GO:0008194,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0015980,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033692,GO:0034637,GO:0034645,GO:0035251,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0046527,GO:0055114,GO:0071704,GO:1901576 2.4.1.21 ko:K00703 ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026 M00565 R02421 RC00005 ko00000,ko00001,ko00002,ko01000,ko01003 - GT5 - Glyco_transf_5,Glycos_transf_1 k59_1560689_1 1229909.NSED_02355 4.69e-06 55.1 arCOG08733@1|root,arCOG08733@2157|Archaea,41SRN@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1614620_1 42565.FP66_09685 1.05e-81 246.0 28PFD@1|root,2ZC6I@2|Bacteria,1R8PT@1224|Proteobacteria,1S2BA@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - VP2004 - - - - - - - - - - - - k59_1614620_2 1123366.TH3_02775 8.39e-17 80.1 COG0697@1|root,COG0697@2|Bacteria,1MXJY@1224|Proteobacteria,2TVBG@28211|Alphaproteobacteria,2JSA7@204441|Rhodospirillales 204441|Rhodospirillales EG EamA-like transporter family - - - - - - - - - - - - EamA k59_1614622_1 1121013.P873_12300 1.63e-54 180.0 arCOG08211@1|root,2ZBM3@2|Bacteria,1RIRV@1224|Proteobacteria,1SFXN@1236|Gammaproteobacteria,1X59H@135614|Xanthomonadales 135614|Xanthomonadales - - - - - - - - - - - - - - - k59_933806_1 1380600.AUYN01000006_gene314 2.32e-74 235.0 COG1253@1|root,COG1253@2|Bacteria,4NG0I@976|Bacteroidetes,1HWV0@117743|Flavobacteriia 976|Bacteroidetes S CBS domain tlyC - - ko:K03699 - - - - ko00000,ko02042 - - - CBS,CorC_HlyC,DUF21 k59_1503542_1 1415754.JQMK01000002_gene3447 8.69e-74 234.0 28HN6@1|root,2Z7WJ@2|Bacteria,1R5QB@1224|Proteobacteria,1RNJN@1236|Gammaproteobacteria,4667S@72275|Alteromonadaceae 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_1272490_1 1120705.FG95_01525 1.23e-43 165.0 COG2931@1|root,COG2931@2|Bacteria,1QYJ2@1224|Proteobacteria,2TY04@28211|Alphaproteobacteria,2K8VM@204457|Sphingomonadales 204457|Sphingomonadales Q Animal haem peroxidase - - - - - - - - - - - - An_peroxidase k59_1390464_1 994573.T472_0209280 1.41e-58 204.0 COG1472@1|root,COG1472@2|Bacteria,1TP0T@1239|Firmicutes,24932@186801|Clostridia,36EVW@31979|Clostridiaceae 186801|Clostridia G hydrolase, family 3 - - 3.2.1.21 ko:K05349 ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110 - R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040 RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248 ko00000,ko00001,ko01000 - GH3 - Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C k59_1390464_2 1121904.ARBP01000001_gene5599 0.000121 47.4 COG3119@1|root,COG3119@2|Bacteria,4NEM3@976|Bacteroidetes,47M3C@768503|Cytophagia 976|Bacteroidetes P PFAM sulfatase - - - - - - - - - - - - Sulfatase k59_1614626_1 1134474.O59_002704 1.24e-39 143.0 COG0679@1|root,COG0679@2|Bacteria,1N1X9@1224|Proteobacteria,1RMV0@1236|Gammaproteobacteria,1FI2R@10|Cellvibrio 1236|Gammaproteobacteria S Membrane transport protein - - - ko:K07088 - - - - ko00000 - - - Mem_trans k59_481529_1 203122.Sde_2669 3.7e-65 217.0 COG0323@1|root,COG0323@2|Bacteria,1MV61@1224|Proteobacteria,1RM89@1236|Gammaproteobacteria,464TH@72275|Alteromonadaceae 1236|Gammaproteobacteria L This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex mutL GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391 - ko:K03572 ko03430,map03430 - - - ko00000,ko00001,ko03400 - - - DNA_mis_repair,HATPase_c_3,MutL_C k59_1219235_1 340177.Cag_0301 2.42e-111 361.0 COG0457@1|root,COG0859@1|root,COG1912@1|root,COG0457@2|Bacteria,COG0859@2|Bacteria,COG1912@2|Bacteria,1FDZ8@1090|Chlorobi 1090|Chlorobi M S-adenosyl-l-methionine hydroxide adenosyltransferase - - - ko:K22205 - - - - ko00000,ko01000 - - - SAM_adeno_trans k59_1162165_1 314287.GB2207_05252 8.5e-89 268.0 COG0330@1|root,COG0330@2|Bacteria,1MUM8@1224|Proteobacteria,1RNW8@1236|Gammaproteobacteria,1J4PK@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O COG0330 Membrane protease subunits, stomatin prohibitin homologs qmcA - - - - - - - - - - - Band_7 k59_201505_2 585543.HMPREF0969_03101 2.11e-71 231.0 COG2236@1|root,COG2236@2|Bacteria,4PMVG@976|Bacteroidetes,2FQQS@200643|Bacteroidia,4ATBI@815|Bacteroidaceae 976|Bacteroidetes F Phosphoribosyl transferase domain - - - - - - - - - - - - Pribosyltran k59_317279_1 1242864.D187_001768 2.29e-167 485.0 COG0459@1|root,COG0459@2|Bacteria,1MURR@1224|Proteobacteria,42M52@68525|delta/epsilon subdivisions,2WIRK@28221|Deltaproteobacteria,2YUQN@29|Myxococcales 28221|Deltaproteobacteria O Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions groL GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0016465,GO:0032991,GO:0044183,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0051082,GO:0061077,GO:0101031,GO:1990220 - ko:K04077 ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152 - - - ko00000,ko00001,ko03019,ko03029,ko03110,ko04147 - - - Cpn60_TCP1 k59_90510_1 614083.AWQR01000031_gene2688 6.28e-13 64.3 COG0346@1|root,COG0346@2|Bacteria,1MZQY@1224|Proteobacteria,2VT5S@28216|Betaproteobacteria 28216|Betaproteobacteria E Glyoxalase bleomycin resistance protein dioxygenase - - - - - - - - - - - - Glyoxalase k59_90510_3 1038859.AXAU01000004_gene4450 2.27e-67 207.0 COG0346@1|root,COG0346@2|Bacteria,1N2KZ@1224|Proteobacteria,2UBQR@28211|Alphaproteobacteria,3K6CJ@41294|Bradyrhizobiaceae 28211|Alphaproteobacteria E Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily - - - - - - - - - - - - Glyoxalase k59_1442179_1 1333523.L593_03670 7.52e-34 128.0 arCOG01792@1|root,arCOG01792@2157|Archaea,2XSXC@28890|Euryarchaeota,23U7D@183963|Halobacteria 183963|Halobacteria Q COG0500 SAM-dependent methyltransferases arsM - 2.1.1.137 ko:K07755 - - - - ko00000,ko01000 - - - Methyltransf_31 k59_1442181_1 436308.Nmar_0646 1.44e-78 240.0 COG1280@1|root,arCOG01947@2157|Archaea,41T36@651137|Thaumarchaeota 651137|Thaumarchaeota E Lysine exporter protein LysE YggA - - - - - - - - - - - - LysE k59_821860_1 861299.J421_3400 8.11e-22 94.7 COG0612@1|root,COG0612@2|Bacteria,1ZSPT@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Insulinase (Peptidase family M16) - - - - - - - - - - - - Peptidase_M16,Peptidase_M16_C k59_821860_2 1232410.KI421413_gene523 7e-43 154.0 COG1185@1|root,COG1185@2|Bacteria,1MVB9@1224|Proteobacteria,42MTZ@68525|delta/epsilon subdivisions,2WJCE@28221|Deltaproteobacteria,43S7K@69541|Desulfuromonadales 28221|Deltaproteobacteria J Polyribonucleotide nucleotidyltransferase, RNA binding domain pnp GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004654,GO:0005488,GO:0006139,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009892,GO:0009987,GO:0010468,GO:0010605,GO:0010629,GO:0016070,GO:0016071,GO:0016740,GO:0016772,GO:0016779,GO:0019222,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0060255,GO:0065007,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901361,GO:1901363,GO:1901575 2.7.7.8 ko:K00962 ko00230,ko00240,ko03018,map00230,map00240,map03018 M00394 R00437,R00438,R00439,R00440 RC02795 ko00000,ko00001,ko00002,ko01000,ko03016,ko03019 - - - KH_1,PNPase,RNase_PH,RNase_PH_C,S1 k59_821862_1 316407.85674298 2.83e-124 363.0 COG0644@1|root,COG0644@2|Bacteria,1MVU6@1224|Proteobacteria,1RNY5@1236|Gammaproteobacteria,3XMZ6@561|Escherichia 1236|Gammaproteobacteria C Could be part of an electron transfer system required for anaerobic carnitine reduction fixC GO:0006575,GO:0006577,GO:0006807,GO:0008150,GO:0008152,GO:0009437,GO:0009987,GO:0034641,GO:0044237,GO:0071704,GO:0097164,GO:1901564 - ko:K00313 - - - - ko00000,ko01000 - - - DAO,FAD_binding_3,NAD_binding_8 k59_317296_1 311402.Avi_0160 1.61e-05 55.5 COG2931@1|root,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,2TRVY@28211|Alphaproteobacteria,4BEGD@82115|Rhizobiaceae 28211|Alphaproteobacteria Q Haemolysin-type calcium-binding repeat (2 copies) - - - - - - - - - - - - An_peroxidase,FG-GAP,HemolysinCabind k59_989476_1 1123366.TH3_20773 1.18e-105 313.0 COG1637@1|root,COG1637@2|Bacteria,1NA4I@1224|Proteobacteria,2U8D4@28211|Alphaproteobacteria,2JY53@204441|Rhodospirillales 204441|Rhodospirillales L Pfam:DUF91 - - - ko:K07448 - - - - ko00000,ko02048 - - - NucS k59_1162174_1 1122137.AQXF01000003_gene2338 4.21e-40 140.0 COG0596@1|root,COG0596@2|Bacteria,1R9X7@1224|Proteobacteria,2TWIW@28211|Alphaproteobacteria 28211|Alphaproteobacteria S hydrolases or acyltransferases (alpha beta hydrolase superfamily) - - - - - - - - - - - - Abhydrolase_1,Abhydrolase_6 k59_1162174_2 1122137.AQXF01000003_gene2337 2.51e-119 349.0 COG0351@1|root,COG0351@2|Bacteria,1MU9J@1224|Proteobacteria,2TUKR@28211|Alphaproteobacteria 28211|Alphaproteobacteria H Phosphomethylpyrimidine kinase thiD - 2.7.1.49,2.7.4.7 ko:K00941 ko00730,ko01100,map00730,map01100 M00127 R03471,R04509 RC00002,RC00017 ko00000,ko00001,ko00002,ko01000 - - - Glyoxalase,Phos_pyr_kin k59_1162174_3 1122137.AQXF01000003_gene2336 1.86e-266 736.0 COG1109@1|root,COG1109@2|Bacteria,1MU24@1224|Proteobacteria,2TQWH@28211|Alphaproteobacteria 28211|Alphaproteobacteria G Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate glmM - 5.4.2.10 ko:K03431 ko00520,ko01100,ko01130,map00520,map01100,map01130 - R02060 RC00408 ko00000,ko00001,ko01000 - - - PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV k59_1162174_4 1122137.AQXF01000003_gene2335 1.43e-151 435.0 COG0294@1|root,COG0294@2|Bacteria,1MUIR@1224|Proteobacteria,2TTMG@28211|Alphaproteobacteria 28211|Alphaproteobacteria H Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives folP - 2.5.1.15,2.7.6.3 ko:K00796,ko:K13941 ko00790,ko01100,map00790,map01100 M00126,M00840,M00841 R03066,R03067,R03503 RC00002,RC00017,RC00121,RC00842 ko00000,ko00001,ko00002,ko01000 - - - Pterin_bind k59_659020_1 994479.GL877878_gene3623 1.14e-12 72.0 COG0457@1|root,COG0457@2|Bacteria,2GKX5@201174|Actinobacteria,4E0J1@85010|Pseudonocardiales 201174|Actinobacteria J Belongs to the DEAD box helicase family - - - - - - - - - - - - TPR_19 k59_1111157_1 765911.Thivi_2343 3.01e-61 203.0 COG0469@1|root,COG0469@2|Bacteria,1MU21@1224|Proteobacteria,1RMW3@1236|Gammaproteobacteria,1WXEF@135613|Chromatiales 135613|Chromatiales G Belongs to the pyruvate kinase family - - 2.7.1.40 ko:K00873 ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230 M00001,M00002,M00049,M00050 R00200,R00430,R01138,R01858,R02320 RC00002,RC00015 ko00000,ko00001,ko00002,ko01000,ko04131,ko04147 - - - PK,PK_C k59_1511277_1 316407.85675491 3.45e-155 447.0 28JS0@1|root,2Z9HJ@2|Bacteria,1R7KJ@1224|Proteobacteria,1RQN7@1236|Gammaproteobacteria 1236|Gammaproteobacteria S immune system process yfjL GO:0002252,GO:0002376,GO:0006950,GO:0006952,GO:0008150,GO:0009605,GO:0009607,GO:0009615,GO:0043207,GO:0050896,GO:0051607,GO:0051704,GO:0051707,GO:0098542 - - - - - - - - - - DUF1837,DUF4297 k59_1279752_1 349521.HCH_03840 7.36e-44 150.0 COG2236@1|root,COG2236@2|Bacteria,1MXS1@1224|Proteobacteria,1RPSD@1236|Gammaproteobacteria,1XJDA@135619|Oceanospirillales 135619|Oceanospirillales F Phosphoribosyl transferase domain - - - ko:K07101 - - - - ko00000 - - - Pribosyltran k59_607036_1 1280953.HOC_18459 4.59e-118 354.0 COG1292@1|root,COG1292@2|Bacteria,1MV0K@1224|Proteobacteria,2U4UN@28211|Alphaproteobacteria 28211|Alphaproteobacteria U Belongs to the BCCT transporter (TC 2.A.15) family - - - ko:K03451 - - - - ko00000 2.A.15 - - BCCT k59_1170240_1 1120950.KB892720_gene1865 4.52e-07 57.8 COG1276@1|root,COG2372@1|root,COG1276@2|Bacteria,COG2372@2|Bacteria,2GMKG@201174|Actinobacteria,4DPE5@85009|Propionibacteriales 201174|Actinobacteria P CopC domain - - - ko:K14166 - - - - ko00000,ko02000 - - - CopC,CopD k59_1621688_1 1229909.NSED_03100 3.9e-112 332.0 COG1060@1|root,arCOG00657@2157|Archaea,41S95@651137|Thaumarchaeota 651137|Thaumarchaeota H Radical SAM - - 2.5.1.77 ko:K11780 ko00680,ko01120,map00680,map01120 M00378 R09396 RC01381,RC03002,RC03007 ko00000,ko00001,ko00002,ko01000 - - - Radical_SAM k59_770981_1 158500.BV97_00589 4.77e-63 207.0 COG1541@1|root,COG1541@2|Bacteria,1NT0G@1224|Proteobacteria,2UP2C@28211|Alphaproteobacteria,2K9AS@204457|Sphingomonadales 204457|Sphingomonadales H Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA) - - - - - - - - - - - - - k59_325168_1 926550.CLDAP_30110 3.2e-12 70.5 COG0363@1|root,COG0363@2|Bacteria,2G6S0@200795|Chloroflexi 200795|Chloroflexi G PFAM glucosamine galactosamine-6-phosphate isomerase - - 3.1.1.31 ko:K01057 ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200 M00004,M00006,M00008 R02035 RC00537 ko00000,ko00001,ko00002,ko01000 - - - Glucosamine_iso k59_1336325_1 1415778.JQMM01000001_gene2132 2.9e-106 318.0 COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,1RN5B@1236|Gammaproteobacteria,1J5DQ@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E COG0436 Aspartate tyrosine aromatic aminotransferase alaA GO:0003674,GO:0003824,GO:0004021,GO:0005488,GO:0006082,GO:0006090,GO:0006520,GO:0006522,GO:0006523,GO:0006807,GO:0006950,GO:0006974,GO:0008144,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009058,GO:0009078,GO:0009079,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0019272,GO:0019752,GO:0019842,GO:0030170,GO:0030632,GO:0032787,GO:0033554,GO:0036094,GO:0042221,GO:0042851,GO:0042852,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046144,GO:0046145,GO:0046394,GO:0046416,GO:0046436,GO:0046437,GO:0046677,GO:0047635,GO:0048037,GO:0050662,GO:0050896,GO:0051716,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.6.1.2,2.6.1.66 ko:K14260 ko00220,ko00250,ko00290,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00290,map01100,map01110,map01130,map01210,map01230 - R00258,R01215 RC00006,RC00008,RC00036 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_1_2 k59_1568924_1 1453503.AU05_06065 1.94e-136 418.0 COG1305@1|root,COG4196@1|root,COG1305@2|Bacteria,COG4196@2|Bacteria,1MVAG@1224|Proteobacteria,1RMX2@1236|Gammaproteobacteria 1236|Gammaproteobacteria E transglutaminase-like IV02_11925 - - - - - - - - - - - Bact_transglu_N,DUF2126,Transglut_core k59_659061_1 396588.Tgr7_0274 1.87e-47 173.0 29DE2@1|root,300BX@2|Bacteria,1NC7M@1224|Proteobacteria,1SFWA@1236|Gammaproteobacteria 1236|Gammaproteobacteria - - - - - - - - - - - - - - - k59_1449813_1 1229909.NSED_06335 5.84e-195 547.0 COG0464@1|root,arCOG01307@2157|Archaea,41SA4@651137|Thaumarchaeota 651137|Thaumarchaeota D AAA domain (Cdc48 subfamily) - - - - - - - - - - - - AAA,MIT,Vps4_C k59_607046_1 987059.RBXJA2T_02170 1.37e-72 219.0 COG0093@1|root,COG0093@2|Bacteria,1RCWZ@1224|Proteobacteria,2VR2N@28216|Betaproteobacteria,1KM02@119065|unclassified Burkholderiales 28216|Betaproteobacteria J Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome rplN - - ko:K02874 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_L14 k59_607046_2 1266925.JHVX01000018_gene1814 2.05e-35 122.0 COG0186@1|root,COG0186@2|Bacteria,1MZIK@1224|Proteobacteria,2VU2G@28216|Betaproteobacteria,373HA@32003|Nitrosomonadales 28216|Betaproteobacteria J One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA rpsQ - - ko:K02961 ko03010,map03010 M00178,M00179 - - br01610,ko00000,ko00001,ko00002,ko03011 - - - Ribosomal_S17 k59_381780_1 118161.KB235922_gene5051 1.25e-47 160.0 COG1309@1|root,COG1309@2|Bacteria,1G58W@1117|Cyanobacteria,3VN4I@52604|Pleurocapsales 1117|Cyanobacteria K Bacterial regulatory proteins, tetR family - - - - - - - - - - - - TetR_C_13,TetR_N k59_1787517_1 221109.22776280 2.62e-18 88.6 COG3639@1|root,COG3639@2|Bacteria,1TR1S@1239|Firmicutes,4HBT8@91061|Bacilli,23JVU@182709|Oceanobacillus 91061|Bacilli P Binding-protein-dependent transport system inner membrane component - - - ko:K02042 ko02010,map02010 M00223 - - ko00000,ko00001,ko00002,ko02000 3.A.1.9 - - BPD_transp_1 k59_545140_1 384765.SIAM614_04660 6.54e-19 88.6 COG3745@1|root,COG3745@2|Bacteria,1MW75@1224|Proteobacteria,2TTPE@28211|Alphaproteobacteria 28211|Alphaproteobacteria U Pilus assembly protein CpaB cpaB - - ko:K02279 - - - - ko00000,ko02035,ko02044 - - - RcpC,SAF k59_891419_1 316407.85676378 3.26e-23 97.4 COG1001@1|root,COG1001@2|Bacteria,1MVFP@1224|Proteobacteria,1RYZ1@1236|Gammaproteobacteria,3XPH7@561|Escherichia 1236|Gammaproteobacteria F adenine deaminase ade GO:0000034,GO:0003674,GO:0003824,GO:0004096,GO:0004601,GO:0005488,GO:0005506,GO:0006040,GO:0006044,GO:0006046,GO:0006139,GO:0006144,GO:0006145,GO:0006146,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008198,GO:0008448,GO:0009056,GO:0009058,GO:0009112,GO:0009113,GO:0009636,GO:0009987,GO:0016209,GO:0016491,GO:0016684,GO:0016787,GO:0016810,GO:0016811,GO:0016814,GO:0018130,GO:0019213,GO:0019239,GO:0019438,GO:0019439,GO:0030145,GO:0034641,GO:0042221,GO:0042440,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0046083,GO:0046100,GO:0046101,GO:0046112,GO:0046113,GO:0046148,GO:0046348,GO:0046483,GO:0046700,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0055086,GO:0055114,GO:0070887,GO:0071704,GO:0072521,GO:0072522,GO:0072523,GO:0097237,GO:0098754,GO:0098869,GO:1901071,GO:1901072,GO:1901135,GO:1901136,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1990748 3.5.4.2 ko:K01486 ko00230,ko01100,map00230,map01100 - R01244 RC00477 ko00000,ko00001,ko01000 - - iECUMN_1333.ECUMN_4192,iSFV_1184.SFV_3844 Adenine_deam_C,Amidohydro_1 k59_891419_2 199310.c4588 1.6e-109 327.0 COG2252@1|root,COG2252@2|Bacteria,1MUV0@1224|Proteobacteria,1RMBE@1236|Gammaproteobacteria,3XPBF@561|Escherichia 1236|Gammaproteobacteria S adenine transmembrane transporter activity yieG GO:0003674,GO:0005215,GO:0005345,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006863,GO:0008150,GO:0015205,GO:0015207,GO:0015851,GO:0015853,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0072530,GO:1904823 - ko:K06901 - - - - ko00000,ko02000 2.A.1.40 - iECH74115_1262.ECH74115_5145,iECOK1_1307.ECOK1_4117,iECSP_1301.ECSP_4762,iECUMN_1333.ECUMN_4191,iECs_1301.ECs4651,iG2583_1286.G2583_4505,iUTI89_1310.UTI89_C4220,iZ_1308.Z5209 Xan_ur_permease k59_1227249_1 402881.Plav_2009 2.18e-200 563.0 COG0183@1|root,COG0183@2|Bacteria,1MUZV@1224|Proteobacteria,2TRHF@28211|Alphaproteobacteria,1JPBG@119043|Rhodobiaceae 28211|Alphaproteobacteria I acetyl-coa acetyltransferase MA20_16305 - 2.3.1.9 ko:K00626 ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020 M00088,M00095,M00373,M00374,M00375 R00238,R01177 RC00004,RC00326 ko00000,ko00001,ko00002,ko01000,ko04147 - - - Thiolase_C k59_489986_1 472759.Nhal_2808 1.71e-21 93.2 COG4301@1|root,COG4301@2|Bacteria,1MUCG@1224|Proteobacteria,1RR44@1236|Gammaproteobacteria,1WVVH@135613|Chromatiales 135613|Chromatiales S Methyltransferase - - 2.1.1.44 ko:K18911 ko00340,map00340 - R01169 RC00003,RC02308 ko00000,ko00001,ko01000 - - - Methyltransf_33 k59_1677584_2 1283299.AUKG01000005_gene146 3.36e-35 133.0 COG0642@1|root,COG2205@2|Bacteria,2GM17@201174|Actinobacteria,4CREI@84995|Rubrobacteria 84995|Rubrobacteria T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HATPase_c,HisKA k59_210748_1 551275.KB899549_gene857 2.58e-26 112.0 COG1629@1|root,COG4771@2|Bacteria,1MWKN@1224|Proteobacteria,2TT5V@28211|Alphaproteobacteria 28211|Alphaproteobacteria P TonB-dependent receptor - - - ko:K02014 - - - - ko00000,ko02000 1.B.14 - - Plug,TonB_dep_Rec k59_608000_1 891974.E05_03200 3.17e-34 125.0 COG2041@1|root,COG4117@1|root,COG2041@2|Bacteria,COG4117@2|Bacteria,1MUW0@1224|Proteobacteria,1RQ2J@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide - - - - - - - - - - - - Ni_hydr_CYTB,Oxidored_molyb k59_608000_2 460265.Mnod_1653 5.49e-92 274.0 COG0625@1|root,COG0625@2|Bacteria,1MUN3@1224|Proteobacteria,2TTVR@28211|Alphaproteobacteria,1JSF7@119045|Methylobacteriaceae 28211|Alphaproteobacteria O Belongs to the GST superfamily - - - ko:K11209 - - - - ko00000,ko01000 - - - GST_C,GST_N k59_153384_2 589873.EP13_17410 1.7e-42 148.0 COG3485@1|root,COG3485@2|Bacteria,1MV6K@1224|Proteobacteria,1TABG@1236|Gammaproteobacteria,46C75@72275|Alteromonadaceae 1236|Gammaproteobacteria Q Dioxygenase - - - - - - - - - - - - Dioxygenase_C k59_383114_1 1234595.C725_0077 2.06e-70 227.0 COG0260@1|root,COG0260@2|Bacteria,1MUIN@1224|Proteobacteria,2TSI6@28211|Alphaproteobacteria,4BPDP@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria E Belongs to the peptidase M17 family pepA - 3.4.11.1 ko:K01255 ko00480,ko01100,map00480,map01100 - R00899,R04951 RC00096,RC00141 ko00000,ko00001,ko01000,ko01002 - - - Peptidase_M17 k59_1787532_2 1340493.JNIF01000003_gene1315 1.61e-42 150.0 COG0330@1|root,COG0330@2|Bacteria,3Y33E@57723|Acidobacteria 57723|Acidobacteria O PFAM Band 7 protein - - - - - - - - - - - - Band_7 k59_608001_1 316407.4062699 3.43e-144 407.0 COG1187@1|root,COG1187@2|Bacteria,1R9VV@1224|Proteobacteria,1S1ZX@1236|Gammaproteobacteria,3XMPV@561|Escherichia 1236|Gammaproteobacteria J Responsible for synthesis of pseudouridine from uracil- 2457 in 23S ribosomal RNA rluE GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360 5.4.99.20 ko:K06181 - - - - ko00000,ko01000,ko03009 - - - PseudoU_synth_2 k59_608001_2 316407.4062698 4.31e-60 187.0 COG1051@1|root,COG1051@2|Bacteria,1N03W@1224|Proteobacteria,1S970@1236|Gammaproteobacteria,3XNRP@561|Escherichia 1236|Gammaproteobacteria F Belongs to the Nudix hydrolase family. NudJ subfamily nudJ GO:0003674,GO:0003824,GO:0004787,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017110,GO:0017111 3.6.1.55 ko:K03574,ko:K12152 - - - - ko00000,ko01000,ko03400 - - iSbBS512_1146.SbBS512_E1312 NUDIX k59_1337527_2 1122604.JONR01000043_gene3187 2.61e-84 257.0 COG0109@1|root,COG0109@2|Bacteria,1MW3S@1224|Proteobacteria,1RNHC@1236|Gammaproteobacteria,1X3GV@135614|Xanthomonadales 135614|Xanthomonadales O Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group cyoE GO:0003674,GO:0003824,GO:0004311,GO:0004659,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0015980,GO:0016020,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044464,GO:0045333,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 2.5.1.141 ko:K02257 ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714 M00154 R07411 RC01786 ko00000,ko00001,ko00002,ko01000,ko01006,ko03029 - - - UbiA k59_1112270_1 756272.Plabr_3458 2.01e-19 89.0 COG0370@1|root,COG0370@2|Bacteria,2IYCI@203682|Planctomycetes 203682|Planctomycetes P transporter of a GTP-driven Fe(2 ) uptake system feoB - - ko:K04759 - - - - ko00000,ko02000 9.A.8.1 - - FeoB_C,FeoB_N,Gate k59_1227269_1 1408164.MOLA814_02588 1.19e-49 167.0 COG1208@1|root,COG1208@2|Bacteria,1MUYJ@1224|Proteobacteria 1224|Proteobacteria JM COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits (eIF-2Bgamma eIF-2Bepsilon) - - 2.7.7.13,2.7.7.71 ko:K00966,ko:K15669 ko00051,ko00520,ko00540,ko01100,ko01110,map00051,map00520,map00540,map01100,map01110 M00114,M00361,M00362 R00885,R09772 RC00002 ko00000,ko00001,ko00002,ko01000 - - - NTP_transferase k59_490004_1 566466.NOR53_1343 5.19e-106 321.0 COG3119@1|root,COG3119@2|Bacteria,1MUJH@1224|Proteobacteria,1RN2V@1236|Gammaproteobacteria,1J7JY@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria P Sulfatase - - 3.1.6.1 ko:K01130 ko00140,ko00600,map00140,map00600 - R03980,R04856 RC00128,RC00231 ko00000,ko00001,ko01000 - - - Sulfatase,Sulfatase_C k59_772375_1 316407.85676260 1.16e-138 398.0 COG1088@1|root,COG1088@2|Bacteria,1MU5E@1224|Proteobacteria,1RP7G@1236|Gammaproteobacteria,3XM8Z@561|Escherichia 1236|Gammaproteobacteria M Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily rffG GO:0000271,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0006139,GO:0006629,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008460,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009225,GO:0009226,GO:0009987,GO:0016051,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0033692,GO:0034637,GO:0034641,GO:0034645,GO:0034654,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045226,GO:0046379,GO:0046483,GO:0048037,GO:0050662,GO:0055086,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901576,GO:1903509 4.2.1.46 ko:K01710 ko00521,ko00523,ko00525,ko01055,ko01130,map00521,map00523,map00525,map01055,map01130 M00793 R06513 RC00402 ko00000,ko00001,ko00002,ko01000 - - iECNA114_1301.ECNA114_3926,iECO26_1355.ECO26_2952,iECSF_1327.ECSF_3628 GDP_Man_Dehyd k59_721373_2 46429.BV95_00999 2.82e-28 107.0 2AKG6@1|root,31B7Z@2|Bacteria,1RFZQ@1224|Proteobacteria,2U7AI@28211|Alphaproteobacteria,2K42D@204457|Sphingomonadales 204457|Sphingomonadales - - - - - - - - - - - - - - - k59_1735398_1 50452.A0A087GGB9 1.6e-13 73.6 COG1028@1|root,KOG1208@2759|Eukaryota,37Q3T@33090|Viridiplantae,3GBAM@35493|Streptophyta,3HZ3Q@3699|Brassicales 35493|Streptophyta Q short-chain dehydrogenase - GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0008150,GO:0008152,GO:0009507,GO:0009526,GO:0009528,GO:0009536,GO:0009706,GO:0009941,GO:0016020,GO:0016491,GO:0019866,GO:0031090,GO:0031967,GO:0031969,GO:0031975,GO:0042170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0055114,GO:0071944 1.1.1.300 ko:K11153,ko:K19329 ko00830,ko01100,map00830,map01100 - R08379,R08383 RC00649 ko00000,ko00001,ko01000 - - - adh_short k59_1735398_2 279714.FuraDRAFT_1192 1.94e-07 51.2 COG0603@1|root,COG0603@2|Bacteria,1MU5V@1224|Proteobacteria,2VHY3@28216|Betaproteobacteria,2KQ1A@206351|Neisseriales 206351|Neisseriales F Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) queC - 6.3.4.20 ko:K06920 ko00790,ko01100,map00790,map01100 - R09978 RC00959 ko00000,ko00001,ko01000,ko03016 - - - QueC k59_1450915_1 697303.Thewi_1839 4.18e-07 56.6 COG3547@1|root,COG3547@2|Bacteria,1TQ5G@1239|Firmicutes,248JG@186801|Clostridia,42FWB@68295|Thermoanaerobacterales 186801|Clostridia L PFAM transposase IS116 IS110 IS902 family protein - - - - - - - - - - - - DEDD_Tnp_IS110,HhH-GPD,Transposase_20 k59_210781_1 436308.Nmar_0441 1.4e-159 449.0 COG2897@1|root,arCOG02019@2157|Archaea,41SZQ@651137|Thaumarchaeota 651137|Thaumarchaeota P Rhodanese Homology Domain - - 2.8.1.1,2.8.1.2 ko:K01011 ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122 - R01931,R03105,R03106 RC00214 ko00000,ko00001,ko01000 - - - Rhodanese k59_326474_1 342610.Patl_1033 6.96e-10 65.1 COG2356@1|root,COG2374@1|root,COG2356@2|Bacteria,COG2374@2|Bacteria,1MX52@1224|Proteobacteria,1RMHH@1236|Gammaproteobacteria,2Q0R9@267888|Pseudoalteromonadaceae 1236|Gammaproteobacteria L extracellular nuclease - - - ko:K07004 - - - - ko00000 - - - Big_5,Endonuclease_1,Exo_endo_phos,LTD k59_383132_2 502025.Hoch_4785 5.48e-46 166.0 COG2355@1|root,COG2355@2|Bacteria,1MWEW@1224|Proteobacteria,42NXB@68525|delta/epsilon subdivisions,2WMBF@28221|Deltaproteobacteria,2YV6N@29|Myxococcales 28221|Deltaproteobacteria E Membrane dipeptidase (Peptidase family M19) - - 3.4.13.19 ko:K01273 - - - - ko00000,ko00537,ko01000,ko01002,ko04147 - - - Peptidase_M19 k59_1112279_1 1380394.JADL01000020_gene1823 4.89e-75 247.0 COG0280@1|root,COG0281@1|root,COG0280@2|Bacteria,COG0281@2|Bacteria,1MU0A@1224|Proteobacteria,2TQJT@28211|Alphaproteobacteria,2JQEQ@204441|Rhodospirillales 204441|Rhodospirillales C malic enzyme tme - 1.1.1.40 ko:K00029 ko00620,ko00710,ko01100,ko01120,ko01200,map00620,map00710,map01100,map01120,map01200 M00169,M00172 R00216 RC00105 ko00000,ko00001,ko00002,ko01000 - - - Malic_M,PTA_PTB,malic k59_1570125_2 493475.GARC_4721 7.22e-107 316.0 COG3384@1|root,COG3384@2|Bacteria,1MWNC@1224|Proteobacteria,1RPH7@1236|Gammaproteobacteria,46A2D@72275|Alteromonadaceae 1236|Gammaproteobacteria S Catalytic LigB subunit of aromatic ring-opening dioxygenase hpaD - 1.13.11.15 ko:K00455 ko00350,ko01120,ko01220,map00350,map01120,map01220 M00533 R03303 RC00643 ko00000,ko00001,ko00002,ko01000 - - iB21_1397.B21_04194,iECBD_1354.ECBD_3668,iECB_1328.ECB_04228,iECD_1391.ECD_04228,iECIAI1_1343.ECIAI1_4573,iECO103_1326.ECO103_5134,iECO26_1355.ECO26_5555,iECSE_1348.ECSE_4627,iECUMN_1333.ECUMN_4973,iEKO11_1354.EKO11_3962,iEcHS_1320.EcHS_A4582,iEcolC_1368.EcolC_3704,iSBO_1134.SBO_4410,iSbBS512_1146.SbBS512_E4888 LigB k59_660604_1 471870.BACINT_00294 9.3e-12 72.8 COG0209@1|root,COG0209@2|Bacteria,4NEHQ@976|Bacteroidetes,2FN30@200643|Bacteroidia,4AKPU@815|Bacteroidaceae 976|Bacteroidetes F Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen nrd - 1.17.4.1 ko:K00525 ko00230,ko00240,ko01100,map00230,map00240,map01100 M00053 R02017,R02018,R02019,R02024 RC00613 ko00000,ko00001,ko00002,ko01000,ko03400 - - - Ribonuc_red_lgC,Ribonuc_red_lgN k59_1622693_1 631362.Thi970DRAFT_02664 5.8e-113 333.0 COG0378@1|root,COG0378@2|Bacteria,1MVBD@1224|Proteobacteria,1RN9Y@1236|Gammaproteobacteria,1WWGI@135613|Chromatiales 135613|Chromatiales KO TIGRFAM Hydrogenase accessory protein HypB - - - ko:K04652 - - - - ko00000,ko03110 - - - cobW k59_1735408_1 717773.Thicy_0459 1.18e-42 149.0 COG0545@1|root,COG0545@2|Bacteria,1RDA1@1224|Proteobacteria,1RPMP@1236|Gammaproteobacteria,460Q6@72273|Thiotrichales 72273|Thiotrichales O Peptidyl-prolyl cis-trans isomerase - - 5.2.1.8 ko:K03773 - - - - ko00000,ko01000,ko03110 - - - FKBP_C,FKBP_N k59_1512591_1 290398.Csal_0683 1.87e-43 154.0 COG1988@1|root,COG1988@2|Bacteria,1QK5N@1224|Proteobacteria,1S0MU@1236|Gammaproteobacteria,1XJQ8@135619|Oceanospirillales 135619|Oceanospirillales S LexA-binding, inner membrane-associated putative hydrolase - - - ko:K07038 - - - - ko00000 - - - YdjM k59_434303_1 1385515.N791_01380 3.84e-10 60.8 COG5587@1|root,COG5587@2|Bacteria,1R4F9@1224|Proteobacteria,1T0YX@1236|Gammaproteobacteria,1X4C1@135614|Xanthomonadales 135614|Xanthomonadales S Conserved hypothetical protein (DUF2461) - - - - - - - - - - - - DUF2461 k59_434303_2 1156935.QWE_13333 2.32e-44 155.0 COG1683@1|root,COG3668@1|root,COG1683@2|Bacteria,COG3668@2|Bacteria,1RHER@1224|Proteobacteria,2UAG5@28211|Alphaproteobacteria,4BMJ1@82115|Rhizobiaceae 28211|Alphaproteobacteria S Protein of unknown function (DUF523) - - - - - - - - - - - - DUF523 k59_434303_3 397278.JOJN01000005_gene770 2.08e-29 112.0 COG1733@1|root,COG1733@2|Bacteria,2GMK5@201174|Actinobacteria,4DQI2@85009|Propionibacteriales 201174|Actinobacteria K HxlR-like helix-turn-helix - - - - - - - - - - - - HxlR,SCP2 k59_383137_1 316407.1800081 8.94e-11 59.7 COG0637@1|root,COG0637@2|Bacteria,1PUMZ@1224|Proteobacteria,1RNJC@1236|Gammaproteobacteria,3XP7X@561|Escherichia 1236|Gammaproteobacteria S beta-phosphoglucomutase activity yqaB GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008801,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0016853,GO:0016866,GO:0016868,GO:0042578,GO:0043167,GO:0043169,GO:0044237,GO:0046872 - - - - - - - - - iSF_1195.SF2717,iSFxv_1172.SFxv_2981,iS_1188.S2904 HAD_2 k59_383137_2 316407.85675523 1.69e-96 281.0 COG1238@1|root,COG1238@2|Bacteria,1RHUV@1224|Proteobacteria,1S69A@1236|Gammaproteobacteria,3XPQC@561|Escherichia 1236|Gammaproteobacteria S SNARE associated Golgi protein yqaA GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944 - - - - - - - - - - SNARE_assoc k59_383137_3 316407.1800079 2.94e-61 201.0 COG2918@1|root,COG2918@2|Bacteria,1MW9B@1224|Proteobacteria,1RPNQ@1236|Gammaproteobacteria,3XNK6@561|Escherichia 1236|Gammaproteobacteria H Belongs to the glutamate--cysteine ligase type 1 family. Type 1 subfamily gshA GO:0003674,GO:0003824,GO:0004357,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006518,GO:0006575,GO:0006749,GO:0006750,GO:0006790,GO:0006807,GO:0006950,GO:0006970,GO:0006972,GO:0008150,GO:0008152,GO:0009058,GO:0009628,GO:0009987,GO:0010035,GO:0010038,GO:0016874,GO:0016879,GO:0016881,GO:0019184,GO:0034641,GO:0042221,GO:0042398,GO:0043043,GO:0043167,GO:0043169,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044424,GO:0044444,GO:0044464,GO:0046685,GO:0046689,GO:0046872,GO:0050896,GO:0051186,GO:0051188,GO:0051716,GO:0070887,GO:0071241,GO:0071243,GO:0071248,GO:0071288,GO:0071704,GO:1901564,GO:1901566,GO:1901576 6.3.2.2 ko:K01919 ko00270,ko00480,ko01100,map00270,map00480,map01100 M00118 R00894,R10993 RC00064,RC00090 ko00000,ko00001,ko00002,ko01000 - - iEC042_1314.EC042_2885 Glu_cys_ligase k59_1337575_2 926569.ANT_05300 3.44e-53 184.0 COG0843@1|root,COG0843@2|Bacteria,2G5XS@200795|Chloroflexi 200795|Chloroflexi C Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B - - 1.9.3.1 ko:K02274 ko00190,ko01100,map00190,map01100 M00155 R00081 RC00016 ko00000,ko00001,ko00002,ko01000 3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6 - - COX1 k59_721413_1 640081.Dsui_1383 1.91e-56 196.0 COG0475@1|root,COG1226@1|root,COG0475@2|Bacteria,COG1226@2|Bacteria,1MV34@1224|Proteobacteria,2VHQQ@28216|Betaproteobacteria,2KUCM@206389|Rhodocyclales 206389|Rhodocyclales P Belongs to the monovalent cation proton antiporter 2 (cpa2) transporter (TC 2.A.37) family - - - ko:K03455 - - - - ko00000 2.A.37 - - Na_H_Exchanger,TrkA_C,TrkA_N k59_153452_1 402881.Plav_3180 3.24e-50 175.0 COG0008@1|root,COG0008@2|Bacteria,1MUCR@1224|Proteobacteria,2TRSU@28211|Alphaproteobacteria,1JNIY@119043|Rhodobiaceae 28211|Alphaproteobacteria J Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) gltX - 6.1.1.17 ko:K01885 ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120 M00121,M00359,M00360 R05578 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016 - - - tRNA-synt_1c k59_1281024_1 1122137.AQXF01000001_gene2788 2.89e-241 691.0 COG0060@1|root,COG0060@2|Bacteria,1MVBQ@1224|Proteobacteria,2TR3N@28211|Alphaproteobacteria 28211|Alphaproteobacteria J amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) ileS - 6.1.1.5 ko:K01870 ko00970,map00970 M00359,M00360 R03656 RC00055,RC00523 ko00000,ko00001,ko00002,ko01000,ko01007,ko03016 - - - Anticodon_1,tRNA-synt_1,zf-FPG_IleRS k59_1059496_1 2002.JOEQ01000005_gene3678 1.6e-18 90.1 COG0642@1|root,COG2205@2|Bacteria,2GNUQ@201174|Actinobacteria,4EFUW@85012|Streptosporangiales 201174|Actinobacteria T His Kinase A (phosphoacceptor) domain - - - - - - - - - - - - HAMP,HATPase_c,HisKA k59_1512616_1 1144313.PMI10_02665 5.93e-86 268.0 COG0702@1|root,COG0702@2|Bacteria,4NFWH@976|Bacteroidetes,1I01X@117743|Flavobacteriia,2NSR7@237|Flavobacterium 976|Bacteroidetes GM Pfam:SusD - - - ko:K21572 - - - - ko00000,ko02000 8.A.46.1,8.A.46.3 - - SusD-like_3,SusD_RagB k59_434323_1 316407.85676514 3.53e-113 355.0 COG0457@1|root,COG3118@1|root,COG0457@2|Bacteria,COG3118@2|Bacteria,1MVB8@1224|Proteobacteria,1RPSN@1236|Gammaproteobacteria,3XMYE@561|Escherichia 1236|Gammaproteobacteria O cellulose synthase operon protein C bcsC - - ko:K20543 - - - - ko00000,ko02000 1.B.55.3 - - BCSC_C,TPR_16,TPR_19,TPR_8 k59_43129_1 316407.85676302 1.07e-52 170.0 COG0711@1|root,COG0711@2|Bacteria,1RHZ0@1224|Proteobacteria,1S402@1236|Gammaproteobacteria,3XNMY@561|Escherichia 1236|Gammaproteobacteria C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation atpF GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008324,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0031224,GO:0031225,GO:0032991,GO:0033177,GO:0034220,GO:0036442,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044424,GO:0044425,GO:0044464,GO:0044769,GO:0045259,GO:0045263,GO:0046933,GO:0046961,GO:0051179,GO:0051234,GO:0055085,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1902600 - ko:K02109 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - e_coli_core.b3736,iAF1260.b3736,iB21_1397.B21_03564,iBWG_1329.BWG_3427,iE2348C_1286.E2348C_4046,iEC042_1314.EC042_4123,iEC55989_1330.EC55989_4211,iECABU_c1320.ECABU_c42210,iECBD_1354.ECBD_4296,iECB_1328.ECB_03620,iECDH10B_1368.ECDH10B_3923,iECDH1ME8569_1439.ECDH1ME8569_3624,iECD_1391.ECD_03620,iECED1_1282.ECED1_4426,iECH74115_1262.ECH74115_5172,iECIAI1_1343.ECIAI1_3920,iECIAI39_1322.ECIAI39_4340,iECO103_1326.ECO103_4422,iECO111_1330.ECO111_4570,iECO26_1355.ECO26_4842,iECOK1_1307.ECOK1_4185,iECP_1309.ECP_3935,iECS88_1305.ECS88_4158,iECSE_1348.ECSE_4026,iECSF_1327.ECSF_3584,iECSP_1301.ECSP_4786,iECUMN_1333.ECUMN_4266,iECW_1372.ECW_m4039,iECs_1301.ECs4678,iEKO11_1354.EKO11_4609,iETEC_1333.ETEC_4027,iEcDH1_1363.EcDH1_4231,iEcE24377_1341.EcE24377A_4252,iEcHS_1320.EcHS_A3952,iEcSMS35_1347.EcSMS35_4104,iEcolC_1368.EcolC_4258,iG2583_1286.G2583_4532,iJO1366.b3736,iJR904.b3736,iSDY_1059.SDY_4012,iSFV_1184.SFV_3762,iSF_1195.SF3816,iSFxv_1172.SFxv_4159,iSSON_1240.SSON_3883,iS_1188.S3952,iSbBS512_1146.SbBS512_E4185,iUMN146_1321.UM146_18870,iUMNK88_1353.UMNK88_4548,iUTI89_1310.UTI89_C4291,iWFL_1372.ECW_m4039,iY75_1357.Y75_RS18390,iZ_1308.Z5234,ic_1306.c4664 ATP-synt_B k59_43129_2 316407.85676303 2.5e-20 84.7 COG0712@1|root,COG0712@2|Bacteria,1MVRH@1224|Proteobacteria,1S8X2@1236|Gammaproteobacteria,3XMJ4@561|Escherichia 1236|Gammaproteobacteria C F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation atpH GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0036442,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045261,GO:0045262,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0046961,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600 - ko:K02113 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - iSF_1195.SF3815,iSFxv_1172.SFxv_4157,iS_1188.S3953 OSCP k59_721434_1 436308.Nmar_1367 1.01e-89 278.0 arCOG08650@1|root,arCOG08650@2157|Archaea,41SZ5@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_1512624_1 1131451.O1K_00010 8.89e-22 92.0 COG2801@1|root,COG2801@2|Bacteria,1MVN5@1224|Proteobacteria,1RP6D@1236|Gammaproteobacteria,1X5T7@135614|Xanthomonadales 135614|Xanthomonadales L Integrase core domain - - - ko:K07497 - - - - ko00000 - - - rve_3 k59_166276_1 1122137.AQXF01000002_gene141 8.12e-16 75.5 COG0750@1|root,COG0750@2|Bacteria,1MU91@1224|Proteobacteria,2TQXJ@28211|Alphaproteobacteria 28211|Alphaproteobacteria M zinc metalloprotease rseP - - ko:K11749 ko02024,ko04112,map02024,map04112 - - - ko00000,ko00001,ko01000,ko01002 - - - PDZ,PDZ_2,Peptidase_M50 k59_166276_2 1122137.AQXF01000002_gene140 5.71e-57 189.0 COG0743@1|root,COG0743@2|Bacteria,1MU4G@1224|Proteobacteria,2TSD1@28211|Alphaproteobacteria 28211|Alphaproteobacteria I Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) dxr GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006721,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016114,GO:0016491,GO:0016614,GO:0016616,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0030145,GO:0030604,GO:0032787,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046490,GO:0046872,GO:0046914,GO:0048037,GO:0050661,GO:0050662,GO:0051483,GO:0051484,GO:0055114,GO:0070402,GO:0071704,GO:0090407,GO:0097159,GO:1901135,GO:1901265,GO:1901363,GO:1901576 1.1.1.267 ko:K00099 ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130 M00096 R05688 RC01452 ko00000,ko00001,ko00002,ko01000 - - - DXPR_C,DXP_redisom_C,DXP_reductoisom k59_111919_1 243090.RB3271 3.15e-42 151.0 COG0515@1|root,COG0515@2|Bacteria,2IX48@203682|Planctomycetes 203682|Planctomycetes KLT COG0515 Serine threonine protein - - 2.7.11.1 ko:K12132 - - - - ko00000,ko01000,ko01001 - - - Pkinase k59_1800338_1 94122.Shewana3_3225 5.02e-93 290.0 COG2939@1|root,COG2939@2|Bacteria,1MW05@1224|Proteobacteria,1RQJY@1236|Gammaproteobacteria,2QADY@267890|Shewanellaceae 1236|Gammaproteobacteria E Peptidase S10 - - - - - - - - - - - - Peptidase_S10 k59_223433_1 1229909.NSED_03180 2.72e-109 338.0 COG3889@1|root,arCOG01672@2157|Archaea,41SA5@651137|Thaumarchaeota 651137|Thaumarchaeota S Bacterial extracellular solute-binding proteins, family 5 Middle - - - ko:K02035 ko02024,map02024 M00239 - - ko00000,ko00001,ko00002,ko02000 3.A.1.5 - - SBP_bac_5 k59_223444_1 436308.Nmar_1573 8.78e-42 149.0 COG0519@1|root,arCOG00085@2157|Archaea,41SDI@651137|Thaumarchaeota 651137|Thaumarchaeota F Catalyzes the synthesis of GMP from XMP guaA - 6.3.5.2 ko:K01951 ko00230,ko00983,ko01100,map00230,map00983,map01100 M00050 R01230,R01231,R08244 RC00010,RC00204 ko00000,ko00001,ko00002,ko01000,ko01002 - - - GATase,GMP_synt_C,NAD_synthase k59_223444_2 436308.Nmar_1574 3.53e-62 192.0 arCOG08684@1|root,arCOG08684@2157|Archaea 2157|Archaea - - - - - - - - - - - - - - - k59_1350310_1 485913.Krac_10526 4.21e-47 167.0 COG0451@1|root,COG0451@2|Bacteria 2|Bacteria GM ADP-glyceromanno-heptose 6-epimerase activity - - 1.1.1.219,5.1.3.10,5.1.3.2 ko:K00091,ko:K01784,ko:K12454 ko00052,ko00520,ko01100,map00052,map00520,map01100 M00361,M00362,M00632 R00291,R02984,R04266 RC00289,RC00528 ko00000,ko00001,ko00002,ko01000 - - - Epimerase,NAD_binding_10 k59_1183762_1 1122137.AQXF01000005_gene1080 2.92e-105 313.0 COG2267@1|root,COG2267@2|Bacteria,1QU7K@1224|Proteobacteria,2TW27@28211|Alphaproteobacteria 28211|Alphaproteobacteria I Alpha beta hydrolase - - 2.7.10.2,3.3.2.9 ko:K01253,ko:K08253 ko00980,ko04976,ko05204,map00980,map04976,map05204 - R07013,R07014,R07027,R07071,R07072,R07082,R09410,R09417,R09443 RC01447,RC01728,RC01764,RC02528 ko00000,ko00001,ko01000,ko01002 - - - Abhydrolase_1 k59_166322_1 1049564.TevJSym_au00430 1.7e-65 217.0 COG0741@1|root,COG1388@1|root,COG0741@2|Bacteria,COG1388@2|Bacteria,1MWKE@1224|Proteobacteria,1RMFZ@1236|Gammaproteobacteria,1J524@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria M COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains) mltD GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0008150,GO:0008932,GO:0008933,GO:0009893,GO:0016020,GO:0016740,GO:0016757,GO:0019222,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043085,GO:0044093,GO:0044464,GO:0048518,GO:0050789,GO:0050790,GO:0051341,GO:0051353,GO:0061783,GO:0065007,GO:0065009 - ko:K08307 - - - - ko00000,ko01000,ko01011 - - - LysM,SLT k59_1464116_2 930166.CD58_11670 9.29e-17 84.3 COG3712@1|root,COG3712@2|Bacteria,1MZCK@1224|Proteobacteria,1S88I@1236|Gammaproteobacteria 1236|Gammaproteobacteria PT COG3712 Fe2 -dicitrate sensor, membrane component - - - ko:K07165 - - - - ko00000 - - - DUF4880,DUF4974,FecR k59_1747986_2 523791.Kkor_0400 4.75e-27 106.0 COG1595@1|root,COG1595@2|Bacteria,1N6YE@1224|Proteobacteria,1SFVH@1236|Gammaproteobacteria 1236|Gammaproteobacteria K Belongs to the sigma-70 factor family. ECF subfamily - - - ko:K03088 - - - - ko00000,ko03021 - - - Sigma70_r2,Sigma70_r4_2 k59_281542_1 436308.Nmar_1644 3.12e-41 149.0 arCOG08728@1|root,arCOG08728@2157|Archaea,41SW1@651137|Thaumarchaeota 651137|Thaumarchaeota - - - - - - - - - - - - - - - k59_111964_1 1499502.EV12_2836 6.78e-104 337.0 COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1144@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1144@2|Bacteria,1G2E2@1117|Cyanobacteria,1MMDC@1212|Prochloraceae 1117|Cyanobacteria C Pyruvate:ferredoxin oxidoreductase core domain II nifJ GO:0003674,GO:0003824,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0016491,GO:0050896,GO:0055114 1.2.7.1 ko:K03737 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00173,M00307 R01196,R10866 RC00004,RC02742 br01601,ko00000,ko00001,ko00002,ko01000 - - iJN678.nifJ EKR,Fer4_16,PFOR_II,POR,POR_N,TPP_enzyme_C k59_1183782_2 429009.Adeg_0090 2.38e-08 55.5 COG0463@1|root,COG0463@2|Bacteria,1UJPS@1239|Firmicutes,25F7Y@186801|Clostridia 186801|Clostridia M PFAM glycosyl transferase family 2 - - - - - - - - - - - - Glycos_transf_2 k59_1635757_1 13690.CP98_03205 1.36e-124 363.0 COG2303@1|root,COG2303@2|Bacteria,1MV19@1224|Proteobacteria,2TQKQ@28211|Alphaproteobacteria,2K0FF@204457|Sphingomonadales 204457|Sphingomonadales E Belongs to the GMC oxidoreductase family - - - - - - - - - - - - GMC_oxred_C,GMC_oxred_N k59_844362_1 1122137.AQXF01000005_gene1182 2.51e-106 317.0 COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,2TRPK@28211|Alphaproteobacteria 28211|Alphaproteobacteria E Aminotransferase aatA - 2.6.1.1 ko:K00812 ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230 - R00355,R00694,R00734,R00896,R02433,R02619,R05052 RC00006 ko00000,ko00001,ko01000,ko01007 - - - Aminotran_1_2 k59_558179_1 644282.Deba_0128 2.07e-48 174.0 COG2366@1|root,COG2366@2|Bacteria,1MVMH@1224|Proteobacteria,42M9A@68525|delta/epsilon subdivisions,2WJ3Y@28221|Deltaproteobacteria 28221|Deltaproteobacteria S Penicillin amidase - - 3.5.1.11,3.5.1.97 ko:K01434,ko:K07116 ko00311,ko01130,map00311,map01130 - R02170 RC00166,RC00328 ko00000,ko00001,ko01000,ko01002 - - - Penicil_amidase k59_1294430_2 379066.GAU_0212 4.41e-25 101.0 COG3544@1|root,COG3544@2|Bacteria,1ZTPN@142182|Gemmatimonadetes 142182|Gemmatimonadetes S Domain of unknown function (DUF305) - - - - - - - - - - - - DUF305 k59_955304_2 756272.Plabr_1646 4.35e-30 120.0 COG0642@1|root,COG0784@1|root,COG2202@1|root,COG0642@2|Bacteria,COG0784@2|Bacteria,COG2202@2|Bacteria,2J52D@203682|Planctomycetes 203682|Planctomycetes T COG0642 Signal transduction histidine kinase - - - - - - - - - - - - HATPase_c,HisKA,Response_reg k59_1350352_1 985255.APHJ01000021_gene1438 4.44e-225 636.0 COG1082@1|root,COG1082@2|Bacteria,4NEWC@976|Bacteroidetes,1HY05@117743|Flavobacteriia,2P5FP@244698|Gillisia 976|Bacteroidetes G Glycosyl-hydrolase 97 N-terminal - - 3.2.1.20,3.2.1.3 ko:K01187,ko:K21574 ko00052,ko00500,ko01100,map00052,map00500,map01100 - R00028,R00801,R00802,R01790,R01791,R06087,R06088 RC00028,RC00049,RC00077 ko00000,ko00001,ko01000 - GH31,GH97 - GH97_C,GH97_N,Glyco_hydro_97 k59_784809_1 1166948.JPZL01000001_gene2596 3.08e-79 248.0 COG0477@1|root,COG2814@2|Bacteria,1MV8D@1224|Proteobacteria,1RNF0@1236|Gammaproteobacteria,1XIRA@135619|Oceanospirillales 135619|Oceanospirillales EGP MFS transporter permease - - - - - - - - - - - - MFS_1 k59_1010769_1 118163.Ple7327_2008 1.2e-84 278.0 COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1145@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1145@2|Bacteria,1G2E2@1117|Cyanobacteria,3VJDV@52604|Pleurocapsales 1117|Cyanobacteria C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin nifJ GO:0003674,GO:0003824,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0016491,GO:0050896,GO:0055114 1.2.7.1 ko:K03737 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00173,M00307 R01196,R10866 RC00004,RC02742 br01601,ko00000,ko00001,ko00002,ko01000 - - iJN678.nifJ EKR,Fer4_16,PFOR_II,POR,POR_N,TPP_enzyme_C k59_166358_1 608538.HTH_1469 1.98e-29 113.0 COG0778@1|root,COG0778@2|Bacteria 2|Bacteria C coenzyme F420-1:gamma-L-glutamate ligase activity - - - - - - - - - - - - Nitroreductase,TM1586_NiRdase k59_1125116_1 1131553.JIBI01000029_gene2452 5.36e-07 52.4 COG0845@1|root,COG0845@2|Bacteria,1MU8D@1224|Proteobacteria,2VJR5@28216|Betaproteobacteria,371WC@32003|Nitrosomonadales 28216|Betaproteobacteria M Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family - - - ko:K02005 - - - - ko00000 - - - HlyD_D23 k59_1125116_2 1415778.JQMM01000001_gene2102 1.42e-70 219.0 COG1136@1|root,COG1136@2|Bacteria,1MU45@1224|Proteobacteria,1RNUJ@1236|Gammaproteobacteria,1J5QG@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria V COG1136 ABC-type antimicrobial peptide transport system, ATPase component - - - ko:K02003,ko:K09810 ko02010,map02010 M00255,M00258 - - ko00000,ko00001,ko00002,ko01000,ko02000 3.A.1,3.A.1.125 - - ABC_tran k59_1072318_1 1249627.D779_2058 1.33e-57 187.0 COG0852@1|root,COG0852@2|Bacteria,1MX4B@1224|Proteobacteria,1S2ET@1236|Gammaproteobacteria,1WWDD@135613|Chromatiales 135613|Chromatiales C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoC - 1.6.5.3 ko:K00332 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Complex1_30kDa k59_1072318_2 977880.RALTA_A1035 8.39e-12 62.0 COG0377@1|root,COG0377@2|Bacteria,1MUI2@1224|Proteobacteria,2VIWK@28216|Betaproteobacteria,1K10B@119060|Burkholderiaceae 28216|Betaproteobacteria C NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient nuoB - 1.6.5.3 ko:K00331 ko00190,ko01100,map00190,map01100 M00144 R11945 RC00061 ko00000,ko00001,ko00002,ko01000 3.D.1 - - Oxidored_q6 k59_502317_1 1122137.AQXF01000005_gene1359 2.26e-173 511.0 COG2182@1|root,COG2182@2|Bacteria,1MU3H@1224|Proteobacteria,2U0ZI@28211|Alphaproteobacteria 28211|Alphaproteobacteria G Extracellular solute-binding protein - - - - - - - - - - - - - k59_1239768_1 469008.B21_01154 1.31e-51 171.0 COG3468@1|root,COG3468@2|Bacteria,1R8WV@1224|Proteobacteria,1RPXJ@1236|Gammaproteobacteria,3XQIF@561|Escherichia 1236|Gammaproteobacteria MU Autotransporter beta-domain - - - ko:K12678 - - - - ko00000,ko02000,ko02044 1.B.12.1.1,1.B.12.1.3 - - Autotransporter,Pertactin k59_1239768_2 469008.B21_01153 1.57e-222 623.0 COG3468@1|root,COG3468@2|Bacteria 2|Bacteria MU cell adhesion - - - - - - - - - - - - Pertactin,YbaB_DNA_bd k59_502318_1 1085623.GNIT_3492 1.22e-51 183.0 COG3131@1|root,COG3131@2|Bacteria,1MUNX@1224|Proteobacteria,1RMEB@1236|Gammaproteobacteria,4654Q@72275|Alteromonadaceae 1236|Gammaproteobacteria P Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) mdoG GO:0000271,GO:0005575,GO:0005623,GO:0005975,GO:0005976,GO:0006073,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009250,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0030288,GO:0030313,GO:0031975,GO:0033692,GO:0034637,GO:0034645,GO:0042597,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044464,GO:0051273,GO:0051274,GO:0071704,GO:1901576 - ko:K03670 - - - - ko00000 - - - MdoG k59_1691043_1 1219626.HMPREF1639_05380 7.3e-39 145.0 COG1207@1|root,COG1207@2|Bacteria,1TP88@1239|Firmicutes,248Z3@186801|Clostridia,25QZH@186804|Peptostreptococcaceae 186801|Clostridia M Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain glmU - 2.3.1.157,2.7.7.23 ko:K04042 ko00520,ko01100,ko01130,map00520,map01100,map01130 M00362 R00416,R05332 RC00002,RC00004,RC00166 ko00000,ko00001,ko00002,ko01000 - - - Hexapep,Hexapep_2,NTP_transf_3,NTP_transferase k59_955349_1 1121033.AUCF01000028_gene389 1.79e-39 152.0 COG1196@1|root,COG1352@1|root,COG2201@1|root,COG2202@1|root,COG1196@2|Bacteria,COG1352@2|Bacteria,COG2201@2|Bacteria,COG2202@2|Bacteria,1NWNJ@1224|Proteobacteria,2TW84@28211|Alphaproteobacteria,2JYXK@204441|Rhodospirillales 204441|Rhodospirillales NT PAS domain - - 2.1.1.80,3.1.1.61 ko:K13924 ko02020,ko02030,map02020,map02030 M00506 - - ko00000,ko00001,ko00002,ko01000,ko02022,ko02035 - - - CheB_methylest,CheR,CheR_N,PAS_10 k59_223513_1 648885.KB316286_gene2433 5.1e-50 178.0 COG1216@1|root,COG1216@2|Bacteria,1MX5Z@1224|Proteobacteria,2U0IP@28211|Alphaproteobacteria,1JRY7@119045|Methylobacteriaceae 28211|Alphaproteobacteria S PFAM Glycosyl transferase family 2 - - - ko:K20444 - - - - ko00000,ko01000,ko01005,ko02000 4.D.1.3 GT2,GT4 - Glycos_transf_2 k59_673266_1 1121949.AQXT01000002_gene3091 8.91e-13 72.0 COG2267@1|root,COG2267@2|Bacteria,1R9GQ@1224|Proteobacteria,2U3YF@28211|Alphaproteobacteria,43X16@69657|Hyphomonadaceae 28211|Alphaproteobacteria I hydrolases or acyltransferases (alpha beta hydrolase superfamily) - - - - - - - - - - - - Abhydrolase_6 k59_112037_1 1209072.ALBT01000038_gene2306 4.53e-57 199.0 COG1629@1|root,COG4206@1|root,COG1629@2|Bacteria,COG4206@2|Bacteria,1R5NN@1224|Proteobacteria,1S06T@1236|Gammaproteobacteria,1FGCB@10|Cellvibrio 1236|Gammaproteobacteria P TonB dependent receptor - - - - - - - - - - - - Plug,TonB_dep_Rec k59_1800468_1 644548.SCNU_14816 1.39e-12 66.2 COG3427@1|root,COG3427@2|Bacteria,2IK4M@201174|Actinobacteria,4GEGQ@85026|Gordoniaceae 201174|Actinobacteria S Polyketide cyclase / dehydrase and lipid transport - - - - - - - - - - - - Polyketide_cyc2 k59_1800468_2 446462.Amir_4942 1.92e-33 127.0 COG1028@1|root,COG1028@2|Bacteria,2GIYQ@201174|Actinobacteria,4E0AR@85010|Pseudonocardiales 201174|Actinobacteria IQ Enoyl-(Acyl carrier protein) reductase - - - - - - - - - - - - adh_short k59_1010821_1 498211.CJA_0533 1.26e-18 86.3 COG3866@1|root,COG3866@2|Bacteria,1R9Q3@1224|Proteobacteria,1S3TY@1236|Gammaproteobacteria 1236|Gammaproteobacteria G Pectate lyase pel GO:0005575,GO:0005576 4.2.2.2 ko:K01728 ko00040,ko02024,map00040,map02024 - R02361,R06240 RC00049,RC00705 ko00000,ko00001,ko01000 - - - Pec_lyase_C k59_673276_1 765913.ThidrDRAFT_3719 5.66e-73 234.0 COG3420@1|root,COG3420@2|Bacteria,1R5QH@1224|Proteobacteria,1SZFN@1236|Gammaproteobacteria 1236|Gammaproteobacteria P alginic acid biosynthetic process - - - - - - - - - - - - - k59_1294474_2 1397666.RS24_01764 2.17e-28 110.0 COG0284@1|root,COG0284@2|Bacteria,1MW2C@1224|Proteobacteria,2TTB3@28211|Alphaproteobacteria,4BQKR@82117|unclassified Alphaproteobacteria 28211|Alphaproteobacteria F Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) pyrF GO:0003674,GO:0003824,GO:0004590,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006206,GO:0006207,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019856,GO:0034641,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046112,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576 4.1.1.23 ko:K01591 ko00240,ko01100,map00240,map01100 M00051 R00965 RC00409 ko00000,ko00001,ko00002,ko01000 - - - OMPdecase k59_955371_2 35754.JNYJ01000055_gene9976 6.84e-84 252.0 COG0412@1|root,COG0412@2|Bacteria,2GTZG@201174|Actinobacteria,4DDTB@85008|Micromonosporales 201174|Actinobacteria Q Dienelactone hydrolase family - - - - - - - - - - - - DLH k59_1072360_1 713586.KB900536_gene3090 4.18e-88 276.0 COG0518@1|root,COG0519@1|root,COG0518@2|Bacteria,COG0519@2|Bacteria,1MU2A@1224|Proteobacteria,1RP81@1236|Gammaproteobacteria,1WVVJ@135613|Chromatiales 135613|Chromatiales F Catalyzes the synthesis of GMP from XMP guaA - 6.3.5.2 ko:K01951 ko00230,ko00983,ko01100,map00230,map00983,map01100 M00050 R01230,R01231,R08244 RC00010,RC00204 ko00000,ko00001,ko00002,ko01000,ko01002 - - - GATase,GMP_synt_C,NAD_synthase k59_558243_1 1121930.AQXG01000001_gene1092 1.22e-65 213.0 COG0438@1|root,COG0438@2|Bacteria 2|Bacteria M transferase activity, transferring glycosyl groups pimC GO:0000009,GO:0000030,GO:0003674,GO:0003824,GO:0004376,GO:0006629,GO:0006643,GO:0006664,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009247,GO:0009987,GO:0016740,GO:0016757,GO:0016758,GO:0033164,GO:0043750,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0046467,GO:0070085,GO:0071704,GO:0097502,GO:1901135,GO:1901137,GO:1901576,GO:1903509 - ko:K14335 - - - - ko00000,ko01000,ko01003 - GT4 - Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1 k59_558243_2 1122137.AQXF01000005_gene998 2.83e-24 99.8 COG0438@1|root,COG0438@2|Bacteria,1MUB7@1224|Proteobacteria,2TQQ0@28211|Alphaproteobacteria 28211|Alphaproteobacteria M glycosyl transferase group 1 - - - - - - - - - - - - Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1 k59_844426_1 948106.AWZT01000046_gene4581 2.04e-51 181.0 COG0654@1|root,COG0654@2|Bacteria,1MUN4@1224|Proteobacteria,2VN4I@28216|Betaproteobacteria,1KH0M@119060|Burkholderiaceae 28216|Betaproteobacteria CH FAD binding domain - - - - - - - - - - - - FAD_binding_3 k59_1010844_1 1415778.JQMM01000001_gene1522 2.13e-79 260.0 COG2844@1|root,COG2844@2|Bacteria,1MV54@1224|Proteobacteria,1RN5T@1236|Gammaproteobacteria,1J51H@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria O Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen glnD GO:0003674,GO:0003824,GO:0006082,GO:0006464,GO:0006520,GO:0006541,GO:0006542,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008773,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016740,GO:0016772,GO:0016779,GO:0019538,GO:0019752,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044283,GO:0046394,GO:0070569,GO:0071704,GO:0140096,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607 2.7.7.59 ko:K00990 ko02020,map02020 - - - ko00000,ko00001,ko01000 - - - ACT,GlnD_UR_UTase,HD,NTP_transf_2 k59_955404_1 314266.SKA58_06535 4.98e-17 79.7 COG0224@1|root,COG0224@2|Bacteria,1MU28@1224|Proteobacteria,2TR11@28211|Alphaproteobacteria,2K0A5@204457|Sphingomonadales 204457|Sphingomonadales C Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex atpG - - ko:K02115 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194 3.A.2.1 - - ATP-synt k59_955404_2 290397.Adeh_4348 2.64e-31 120.0 COG0055@1|root,COG0055@2|Bacteria,1MUFU@1224|Proteobacteria,42KZA@68525|delta/epsilon subdivisions,2WJ1V@28221|Deltaproteobacteria,2YU1A@29|Myxococcales 28221|Deltaproteobacteria F Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits atpD - 3.6.3.14 ko:K02112 ko00190,ko00195,ko01100,map00190,map00195,map01100 M00157 - - ko00000,ko00001,ko00002,ko00194,ko01000 3.A.2.1 - - ATP-synt_ab,ATP-synt_ab_N k59_447210_1 1463825.JNXC01000002_gene4468 6.22e-50 169.0 COG1136@1|root,COG1136@2|Bacteria,2GK3I@201174|Actinobacteria,4E1DQ@85010|Pseudonocardiales 201174|Actinobacteria V ATPases associated with a variety of cellular activities - - - ko:K02003 - M00258 - - ko00000,ko00002,ko02000 3.A.1 - - ABC_tran k59_1072380_2 1229909.NSED_09560 7.83e-103 308.0 COG0446@1|root,arCOG01064@2157|Archaea,41SZR@651137|Thaumarchaeota 651137|Thaumarchaeota S Pyridine nucleotide-disulphide oxidoreductase - - 1.8.5.4 ko:K17218 ko00920,map00920 - R10152 RC03155 ko00000,ko00001,ko01000 - - - Pyr_redox_2 k59_673330_1 1415778.JQMM01000001_gene1079 9.8e-80 253.0 COG1305@1|root,COG1305@2|Bacteria,1MVV3@1224|Proteobacteria,1RRIA@1236|Gammaproteobacteria,1J593@118884|unclassified Gammaproteobacteria 1236|Gammaproteobacteria E K COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit IV02_00930 - - - - - - - - - - - 7TM_transglut,Transglut_i_TM k59_447219_2 1280001.BAOA01000051_gene1502 9.99e-16 80.9 COG4067@1|root,COG4067@2|Bacteria,1R9C1@1224|Proteobacteria,1S122@1236|Gammaproteobacteria,1XUBD@135623|Vibrionales 135623|Vibrionales O Putative ATP-dependant zinc protease - - - - - - - - - - - - Zn_protease k59_844441_1 402881.Plav_2640 3.2e-124 360.0 COG1024@1|root,COG1024@2|Bacteria,1MWZC@1224|Proteobacteria,2TRIH@28211|Alphaproteobacteria,1JQ49@119043|Rhodobiaceae 28211|Alphaproteobacteria I Enoyl-CoA hydratase/isomerase MA20_16365 - 4.2.1.149 ko:K08299 - - R10675 RC01095 ko00000,ko01000 - - - ECH_1 k59_1125163_1 199310.c1511 2.2e-41 140.0 COG2915@1|root,COG2915@2|Bacteria,1RI8B@1224|Proteobacteria,1RPCC@1236|Gammaproteobacteria,3XMJX@561|Escherichia 1236|Gammaproteobacteria S Negative regulator of phage lambda lysogenization. Contributes to the degradation of the phage regulatory protein CII. Acts probably by holding CII on the membrane surface, away from the target promoters, but close to the FtsH protease hflD GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006950,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009898,GO:0016020,GO:0019897,GO:0019898,GO:0031234,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0071944,GO:0098552,GO:0098562 - ko:K07153 - - - - ko00000 - - - DUF489 k59_1125163_2 511145.b1133 4.99e-274 748.0 COG0482@1|root,COG0482@2|Bacteria,1MUT1@1224|Proteobacteria,1RMAK@1236|Gammaproteobacteria,3XN22@561|Escherichia 1236|Gammaproteobacteria J Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA(Lys), tRNA(Glu) and tRNA(Gln), leading to the formation of s(2)U34, the first step of tRNA-mnm(5)s(2)U34 synthesis. Sulfur is provided by IscS, via a sulfur-relay system. Binds ATP and its substrate tRNAs mnmA GO:0001510,GO:0002097,GO:0002098,GO:0002143,GO:0003674,GO:0003824,GO:0004808,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016741,GO:0016782,GO:0016783,GO:0030488,GO:0032259,GO:0034227,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360 2.8.1.13 ko:K00566 ko04122,map04122 - R08700 RC02313,RC02315 ko00000,ko00001,ko01000,ko03016 - - - tRNA_Me_trans k59_1125163_3 316407.4062698 9.94e-19 79.7 COG1051@1|root,COG1051@2|Bacteria,1N03W@1224|Proteobacteria,1S970@1236|Gammaproteobacteria,3XNRP@561|Escherichia 1236|Gammaproteobacteria F Belongs to the Nudix hydrolase family. NudJ subfamily nudJ GO:0003674,GO:0003824,GO:0004787,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017110,GO:0017111 3.6.1.55 ko:K03574,ko:K12152 - - - - ko00000,ko01000,ko03400 - - iSbBS512_1146.SbBS512_E1312 NUDIX k59_955418_1 661087.HMPREF1008_00209 1.79e-05 51.6 COG2964@1|root,COG2964@2|Bacteria,2I90J@201174|Actinobacteria,4CWSM@84998|Coriobacteriia 84998|Coriobacteriia S YheO-like PAS domain - - - - - - - - - - - - HTH_22,PAS_6 k59_955418_2 1079460.ATTQ01000005_gene2211 1.05e-41 140.0 COG2164@1|root,COG2164@2|Bacteria,1RCY5@1224|Proteobacteria,2U5NN@28211|Alphaproteobacteria,4BDY3@82115|Rhizobiaceae 28211|Alphaproteobacteria S Protein of unknown function (DUF3830) - - - - - - - - - - - - DUF3830 k59_223575_1 385682.AFSL01000023_gene2126 2.41e-89 272.0 COG1192@1|root,COG1192@2|Bacteria,4NFEX@976|Bacteroidetes,2FMX2@200643|Bacteroidia,3XJKX@558415|Marinilabiliaceae 976|Bacteroidetes D Cellulose biosynthesis protein BcsQ soj - - ko:K03496 - - - - ko00000,ko03036,ko04812 - - - AAA_31 k59_1800523_1 641526.ADIWIN_0210 2.04e-103 320.0 COG1472@1|root,COG1472@2|Bacteria,4NE90@976|Bacteroidetes,1HX27@117743|Flavobacteriia 976|Bacteroidetes G Belongs to the glycosyl hydrolase 3 family bglX - 3.2.1.21 ko:K05349 ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110 - R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040 RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248 ko00000,ko00001,ko01000 - GH3 - Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C k59_223588_1 1248917.ANFX01000012_gene1790 2.06e-10 68.2 COG3827@1|root,COG3827@2|Bacteria,1QQR0@1224|Proteobacteria,2U38X@28211|Alphaproteobacteria,2K2AW@204457|Sphingomonadales 204457|Sphingomonadales - - - - - - - - - - - - - - - k59_223588_2 383381.EH30_10075 4.04e-29 119.0 COG3193@1|root,COG3193@2|Bacteria,1R3RC@1224|Proteobacteria,2U39K@28211|Alphaproteobacteria,2K2UI@204457|Sphingomonadales 204457|Sphingomonadales S Haem-degrading - - - - - - - - - - - - Haem_degrading k59_1350446_1 1121405.dsmv_2597 1.17e-186 550.0 COG1674@1|root,COG1674@2|Bacteria,1MVPI@1224|Proteobacteria,42N4X@68525|delta/epsilon subdivisions,2WIPR@28221|Deltaproteobacteria,2MI69@213118|Desulfobacterales 28221|Deltaproteobacteria D DNA segregation ATPase, FtsK SpoIIIE family ftsK - - ko:K03466 - - - - ko00000,ko03036 3.A.12 - - FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma k59_448756_2 1288826.MSNKSG1_04681 1.25e-85 258.0 COG4221@1|root,COG4221@2|Bacteria,1PWXN@1224|Proteobacteria,1S226@1236|Gammaproteobacteria,4671I@72275|Alteromonadaceae 1236|Gammaproteobacteria S Domain of unknown function (DUF4336) - - - - - - - - - - - - DUF4336 k59_168001_1 316407.1651260 1.71e-117 343.0 COG0797@1|root,COG0797@2|Bacteria,1MZ8S@1224|Proteobacteria,1RMCG@1236|Gammaproteobacteria,3XP5D@561|Escherichia 1236|Gammaproteobacteria M Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides rlpA GO:0005575,GO:0005623,GO:0009279,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0044462,GO:0044464,GO:0071944 - ko:K03642 - - - - ko00000 - - - DPBB_1,SPOR k59_1802038_1 523791.Kkor_2055 6.23e-79 248.0 COG0624@1|root,COG0624@2|Bacteria,1MVUX@1224|Proteobacteria,1RPPD@1236|Gammaproteobacteria,1XN6B@135619|Oceanospirillales 135619|Oceanospirillales E TIGRFAM amidase, hydantoinase carbamoylase - - 3.5.1.6,3.5.1.87 ko:K06016 ko00240,ko01100,map00240,map01100 M00046 R00905,R04666 RC00096 ko00000,ko00001,ko00002,ko01000 - - - M20_dimer,Peptidase_M20 k59_957012_1 1049564.TevJSym_br00020 7.13e-47 171.0 COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1145@1|root,COG1146@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1145@2|Bacteria,COG1146@2|Bacteria,1MVM0@1224|Proteobacteria,1RNNX@1236|Gammaproteobacteria 1236|Gammaproteobacteria C Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin - - 1.2.7.1 ko:K03737 ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200 M00173,M00307 R01196,R10866 RC00004,RC02742 br01601,ko00000,ko00001,ko00002,ko01000 - - - Fer4,Fer4_13,Fer4_6,PFOR_II,POR,POR_N,TPP_enzyme_C k59_1185358_1 436308.Nmar_1257 8.98e-52 173.0 arCOG08033@1|root,arCOG08033@2157|Archaea 2157|Archaea C copper ion binding - - - - - - - - - - - - - k59_957014_1 745718.JADT01000020_gene291 9.22e-94 286.0 COG1066@1|root,COG1066@2|Bacteria,4NEYA@976|Bacteroidetes,1HY3T@117743|Flavobacteriia 976|Bacteroidetes O DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function radA - - ko:K04485 - - - - ko00000,ko03400 - - - AAA_25,ATPase,ChlI ## 27105 queries scanned ## Total time (seconds): 158.30996179580688 ## Rate: 171.21 q/s